BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q9Y6A2 (500 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 3MDV-A nrPDB 921 0.0 6DA2-A nrPDB 147 7e-36 5VEU-A nrPDB 140 1e-33 6C94-A nrPDB 137 2e-32 3EL3-A nrPDB 137 2e-32 5YLW-A nrPDB 122 5e-28 6AYB-A nrPDB 119 4e-27 4KPA-A nrPDB 113 2e-25 3K9V-A nrPDB 107 1e-23 2VE3-A nrPDB 105 5e-23 1WIY-A nrPDB 105 6e-23 4R20-A nrPDB 102 3e-22 5E58-A nrPDB 99 5e-21 3JUS-A nrPDB 97 1e-20 6CR2-A nrPDB 97 1e-20 2W0A-A nrPDB 97 2e-20 5E0E-A nrPDB 97 2e-20 6B82-A nrPDB 96 3e-20 4H1N-A nrPDB 96 3e-20 5UYS-A nrPDB 96 3e-20 2PG7-A nrPDB 96 4e-20 3DL9-A nrPDB 94 2e-19 2NNH-A nrPDB 91 1e-18 4R1Z-A nrPDB 90 3e-18 3S79-A nrPDB 89 4e-18 3IBD-A nrPDB 89 5e-18 5W0C-A nrPDB 87 2e-17 3QZ1-A nrPDB 86 4e-17 5VBU-A nrPDB 86 5e-17 3TBG-A nrPDB 83 3e-16 1N6B-A nrPDB 82 7e-16 2HI4-A nrPDB 81 1e-15 6IQ5-A nrPDB 79 6e-15 4GQS-A nrPDB 78 8e-15 3MZS-A nrPDB 76 3e-14 5FSA-A nrPDB 75 5e-14 4WMZ-A nrPDB 75 6e-14 5JLC-A nrPDB 74 2e-13 3E6I-A nrPDB 73 3e-13 3N9Z-A nrPDB 71 9e-13 4GGV-A nrPDB 68 1e-11 6DWN-A nrPDB 68 1e-11 4UBS-A nrPDB 65 7e-11 4ZGX-A nrPDB 64 1e-10 5Z9I-A nrPDB 64 1e-10 3L4D-A nrPDB 63 3e-10 5HDI-A nrPDB 63 3e-10 3EJB-B nrPDB 63 4e-10 2Y5N-A nrPDB 62 6e-10 6GMF-A nrPDB 62 6e-10 2WX2-A nrPDB 61 1e-09 2Z36-A nrPDB 60 2e-09 3MGX-A nrPDB 60 2e-09 6M7X-A nrPDB 58 8e-09 3WVS-A nrPDB 58 8e-09 5L94-A nrPDB 58 9e-09 6B11-A nrPDB 58 9e-09 5FOI-A nrPDB 58 1e-08 3ABB-A nrPDB 57 1e-08 2ZBZ-A nrPDB 57 2e-08 3P3Z-A nrPDB 57 3e-08 2X2N-A nrPDB 56 4e-08 2VZM-A nrPDB 55 7e-08 5IT1-A nrPDB 55 9e-08 5YSW-A nrPDB 55 1e-07 1ODO-A nrPDB 54 1e-07 4MM0-A nrPDB 54 2e-07 2WIY-A nrPDB 53 3e-07 5Y1I-A nrPDB 53 4e-07 5CJE-A nrPDB 52 4e-07 5XW2-A nrPDB 52 6e-07 3R9C-A nrPDB 52 6e-07 5VWS-A nrPDB 52 9e-07 3ABA-A nrPDB 51 1e-06 6DCD-A nrPDB 51 1e-06 3NC3-A nrPDB 50 2e-06 4Z5P-A nrPDB 50 2e-06 5LIV-A nrPDB 50 2e-06 5OFQ-A nrPDB 50 3e-06 4OQR-A nrPDB 49 5e-06 6F88-A nrPDB 49 5e-06 2WIO-A nrPDB 49 5e-06 1CPT-A nrPDB 49 6e-06 4TRI-A nrPDB 49 7e-06 3TKT-A nrPDB 48 8e-06 6GII-A nrPDB 48 1e-05 4OQS-A nrPDB 48 1e-05 6GK6-A nrPDB 48 1e-05 6CVC-A nrPDB 47 2e-05 3RWL-A nrPDB 47 3e-05 3SN5-A nrPDB 47 3e-05 1EHE-A nrPDB 45 6e-05 2NZA-A nrPDB 44 1e-04 4C9K-A nrPDB 44 1e-04 5KYO-A nrPDB 44 2e-04 2WM5-A nrPDB 44 2e-04 5NWS-A nrPDB 43 3e-04 4WPZ-A nrPDB 43 3e-04 3TYW-A nrPDB 42 4e-04 5DQN-A nrPDB 42 5e-04 3A50-A nrPDB 42 6e-04 4RM4-A nrPDB 42 0.001 5HIW-A nrPDB 41 0.001 4FB2-A nrPDB 41 0.001 2RFC-A nrPDB 40 0.002 6FYJ-A nrPDB 40 0.002 5XNT-A nrPDB 40 0.002 5L1U-A nrPDB 40 0.003 1F4U-A nrPDB 39 0.005 1GWI-A nrPDB 39 0.005 5EX6-C nrPDB 39 0.006 3IVY-A nrPDB 39 0.007 4XE3-A nrPDB 38 0.010 5D3U-A nrPDB 37 0.015 3NV6-A nrPDB 36 0.034 3A1L-A nrPDB 36 0.038 5DE9-A nrPDB 35 0.052 6A7I-A nrPDB 35 0.055 3BUJ-A nrPDB 35 0.068 6A7J-A nrPDB 35 0.095 1Q5D-A nrPDB 34 0.12 6HQG-A nrPDB 34 0.13 2IAG-A nrPDB 33 0.25 3U0R-A nrPDB 32 0.44 3OFT-A nrPDB 32 0.80 6G71-A nrPDB 31 1.0 4TX3-A nrPDB 31 1.3 3A3K-A nrPDB 31 1.6 6FSH-A nrPDB 30 1.6 1LTX-R nrPDB 30 2.2 6NI0-A nrPDB 29 5.1 3UX8-A nrPDB 28 8.3 2R6F-A nrPDB 28 9.2 >3MDV-A nrPDB Length = 456 Score = 921 bits (2381), Expect = 0.0, Method: Compositional matrix adjust. Identities = 450/450 (100%), Positives = 450/450 (100%) Query: 51 KKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYR 110 KKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYR Sbjct: 3 KKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYR 62 Query: 111 ALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEA 170 ALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEA Sbjct: 63 ALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEA 122 Query: 171 KADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLA 230 KADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLA Sbjct: 123 KADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLA 182 Query: 231 KFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDE 290 KFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDE Sbjct: 183 KFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDE 242 Query: 291 GLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRL 350 GLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRL Sbjct: 243 GLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRL 302 Query: 351 QYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLT 410 QYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLT Sbjct: 303 QYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLT 362 Query: 411 FNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGL 470 FNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGL Sbjct: 363 FNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGL 422 Query: 471 QEQATLKPLDPVLCTLRPRGWQPAPPPPPC 500 QEQATLKPLDPVLCTLRPRGWQPAPPPPPC Sbjct: 423 QEQATLKPLDPVLCTLRPRGWQPAPPPPPC 452 >6DA2-A nrPDB Length = 487 Score = 147 bits (372), Expect = 7e-36, Method: Compositional matrix adjust. Identities = 120/477 (25%), Positives = 224/477 (46%), Gaps = 38/477 (7%) Query: 33 IPGPPRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPES 92 IPGP P LG++ + K G + D ++ KKYG V + + +T P+ Sbjct: 18 IPGP-TPLPFLGNILSYHK-----GFCMFD--MECHKKYGKVWGFYDGQQPVLAITDPDM 69 Query: 93 VKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVS 152 +K L+ Y+ + + FG F + +S E W + R ++ F+ L Sbjct: 70 IKTVLVKECYSVFTN-----RRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKE 124 Query: 153 LMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLS 212 ++ + + LV L +A+ PV+++D+ +MD++ +FG+ L Q P Sbjct: 125 MVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFV 184 Query: 213 QAVKLML-----EGITASRNTLAKFLPGKRKQLREVRESIRFLRQVG---RDWVQRRREA 264 + K +L + S +P + EV F R+V R V+R +E+ Sbjct: 185 ENTKKLLRFDFLDPFFLSITVFPFLIP-----ILEVLNICVFPREVTNFLRKSVKRMKES 239 Query: 265 -LKRGEEVPADILTQILKAEEG-------AQDDEGLLDNFVTFFIAGHETSANHLAFTVM 316 L+ ++ D L ++ ++ A D L+ + F AG+ET+++ L+F + Sbjct: 240 RLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMY 299 Query: 317 ELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEE 376 EL+ P++ +LQ E+D V+ +K ++ + +++YL V+ E+LRL+P A R+ ++ Sbjct: 300 ELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKK 359 Query: 377 ETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPK--PRFTYFPFSLGH 434 + I+G+ +P ++ +Y + R Y+ +P F P+RF + Y PF G Sbjct: 360 DVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGP 419 Query: 435 RSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQ--ATLKPLDPVLCTLRPR 489 R+CIG +FA M +K+ + ++LQ F+ + L+ L+P PV+ + R Sbjct: 420 RNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESR 476 >5VEU-A nrPDB Length = 480 Score = 140 bits (354), Expect = 1e-33, Method: Compositional matrix adjust. Identities = 125/475 (26%), Positives = 221/475 (46%), Gaps = 35/475 (7%) Query: 33 IPGPPRPSFLLGHLPCF----WKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVT 88 IPGP P LLG++ + WK D + KKYG + + +T Sbjct: 17 IPGP-TPLPLLGNVLSYRQGLWKFDT-----------ECYKKYGKMWGTYEGQLPVLAIT 64 Query: 89 SPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRS 148 P+ ++ L+ Y+ + R+L G F + +S E W + R ++ F+ Sbjct: 65 DPDVIRTVLVKECYSVFTNR-RSL----GPVGFMKSAISLAEDEEWKRIRSLLSPTFTSG 119 Query: 149 SLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQ 208 L + + + LV L +A+ PV+++D+ +MD++ +FG+ L Q Sbjct: 120 KLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQ 179 Query: 209 KPLSQAVKLMLE-GITAS---RNTLAKFLPGKRKQLREV---RESIRFL-RQVGRDWVQR 260 P ++ K L+ G L FL + L +++I FL + V R R Sbjct: 180 DPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSR 239 Query: 261 RREALK-RGEEVPADILTQILKAEEG--AQDDEGLLDNFVTFFIAGHETSANHLAFTVME 317 + K R + + I +Q K E A D L + F AG+ET+++ L+FT+ E Sbjct: 240 LNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYE 299 Query: 318 LSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEE 377 L+ P++ +LQ E+D V+ +K ++ + +++YL V+ E+LRL+P A R +++ Sbjct: 300 LATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKD 359 Query: 378 TLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPK-PRFTYFPFSLGHRS 436 I+GV +P + ++ TY + Y+ +P F P+RF + Y PF G R+ Sbjct: 360 VEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRN 419 Query: 437 CIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQ--EQATLKPLDPVLCTLRPR 489 CIG +FA M +K+ + ++LQ F+ + L+ Q L+P P++ + R Sbjct: 420 CIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSR 474 >6C94-A nrPDB Length = 497 Score = 137 bits (344), Expect = 2e-32, Method: Compositional matrix adjust. Identities = 111/390 (28%), Positives = 179/390 (45%), Gaps = 27/390 (6%) Query: 122 GQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQ 181 G+GL+ + +W + R+++ F L + F + ++E E KA + Sbjct: 101 GKGLLV-LDGPKWFQHRKLLTPGFHYDVLKPYVAIFADSTRIMLEKWEKKACEGKSFDIF 159 Query: 182 DMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVK----LMLEGITA--SRNTLAKFL-P 234 + + A+D L K FG S L AV LM + I + N +L P Sbjct: 160 SDVGHMALDTLMKCTFGKGDSGLNHRDSSYYVAVSELTLLMQQRIDSFQYHNDFIYWLTP 219 Query: 235 GKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPA----------DILTQILKAEE 284 R+ LR R + +V +++R+ AL+ +E DIL + + E Sbjct: 220 HGRRFLRACRAAHDHTDRV----IRQRKAALQDEKEREKIQNRRHLDFLDILLDV-RGES 274 Query: 285 GAQ-DDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLD 343 G Q D L TF GH+T+ + +++ + ++ PE R + EV E++G + Sbjct: 275 GVQLSDTDLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQQRCREEVREILGDQDSFQ 334 Query: 344 FEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEE-TLIDGVRVPGNTPLLFSTYVMGRMD 402 +EDL ++ YL+ +KE RLYPP +R L + + +DG +P + + Y + R Sbjct: 335 WEDLAKMTYLTMCMKECFRLYPPVPQVYRQLSKPVSFVDGRSLPAGSLISLHIYALHRNS 394 Query: 403 TYFEDPLTFNPDRFGPGAPKPR--FTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEF 460 + DP F+P RF P R + + PFS G R+CIGQQFA E+KVV A L R EF Sbjct: 395 DVWPDPEVFDPLRFSPENSSGRHPYAFIPFSAGPRNCIGQQFAMNEMKVVTALCLLRFEF 454 Query: 461 RLVPGQRFGLQEQATLKPLDPVLCTLRPRG 490 + P + Q L+ + + L+P G Sbjct: 455 SVDPLRLPIKLPQLVLRSKNGIHLYLKPLG 484 >3EL3-A nrPDB Length = 467 Score = 137 bits (344), Expect = 2e-32, Method: Compositional matrix adjust. Identities = 119/453 (26%), Positives = 200/453 (44%), Gaps = 46/453 (10%) Query: 42 LLGHLPCFWKKDEVGGRVLQD--VFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMS 99 LLGH G R+ +D F+ + +G VVR+ + KT VT+PE ++ Sbjct: 33 LLGH----------GWRLARDPLAFMSQLRDHGDVVRIKLGPKTVYAVTNPELTGALALN 82 Query: 100 TKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNE 159 Y+ ++ +L E L G+ V+ N +QRR I AF ++ + E Sbjct: 83 PDYHIAGPLWESL-----EGLLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEE 137 Query: 160 KAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLML 219 +A L E Q T A + A + LL Q +A +L + Sbjct: 138 EAHALTE------------RWQPGKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCV 185 Query: 220 EGITASRNTLAKFL----PGKRKQL---REVRESIRFLRQVGRDWVQRRREALKRGEEVP 272 T R + + P R L R +++ L + + + RR + ++ P Sbjct: 186 ALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQK----P 241 Query: 273 ADILTQILKAEEGAQDDEG---LLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQ 329 D+LT +L+A++ D G + D V G ET A+ + + + L+ PE R++ Sbjct: 242 DDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIR 301 Query: 330 AEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNT 389 EV+ V G R + FED+ +L++ V+ E++RL P W R E+ + G R+P Sbjct: 302 DEVEAVTGG-RPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESELGGYRIPAGA 360 Query: 390 PLLFSTYVMGRMDTYFEDPLTFNPDRFGP--GAPKPRFTYFPFSLGHRSCIGQQFAQMEV 447 +++S Y + R ++D L F+PDR+ P A P++ PFS G R C F+ ++ Sbjct: 361 DIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQL 420 Query: 448 KVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLD 480 ++ A L + F V G ++ TL+P D Sbjct: 421 TLITAALATKYRFEQVAGSNDAVRVGITLRPHD 453 >5YLW-A nrPDB Length = 495 Score = 122 bits (305), Expect = 5e-28, Method: Compositional matrix adjust. Identities = 111/480 (23%), Positives = 214/480 (44%), Gaps = 53/480 (11%) Query: 11 AVLLAFGLCCTFVHRARSRYEHIPGPPRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKK 70 A L TF+ R R ++P P P ++G++ ++G Q VF +K+ Sbjct: 8 AALFFIAATITFLSFRRRR--NLPPGPFPYPIVGNML------QLGANPHQ-VFAKLSKR 58 Query: 71 YGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECN 130 YGP++ +++ +VIV+SPE K+ L +R Q VF R Q V C+ Sbjct: 59 YGPLMSIHLGSLYTVIVSSPEMAKEIL-----------HRHGQ-VFSGRTIAQA-VHACD 105 Query: 131 YER-----------WHKQRRVI-DLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPV 178 +++ W R++ + FS S+ + +K +QL++ ++ +D V Sbjct: 106 HDKISMGFLPVASEWRDMRKICKEQMFSNQSMEASQGLRRQKLQQLLDHVQKCSDSGRAV 165 Query: 179 SMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRN--TLAKFLPGK 236 +++ T +++++ F + + + K ++EG+ A + P Sbjct: 166 DIREAAFITTLNLMSATLFSSQATEF---DSKATMEFKEIIEGVATIVGVPNFADYFPIL 222 Query: 237 RK---QLREVRESIRFLRQVGR--DWVQRRREALKRGEEVPA-----DILTQILKAEEGA 286 R Q + R + F + + + ++ R E+ + P +I+ I++A E Sbjct: 223 RPFDPQGVKRRADVFFGKLLAKIEGYLNERLESKRANPNAPKKDDFLEIVVDIIQANEFK 282 Query: 287 QDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFED 346 + F+ G +T+ + + + EL P+ +ARL+AE+ V G ++ +D Sbjct: 283 LKTHHFTHLMLDLFVGGSDTNTTSIEWAMSELVMNPDKMARLKAELKSVAGDEKIVDESA 342 Query: 347 LGRLQYLSQVLKESLRLYPPAWGTF-RLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYF 405 + +L YL V+KE +R++PP R E + ++G +P T +L + Y +GR + + Sbjct: 343 MPKLPYLQAVIKEVMRIHPPGPLLLPRKAESDQEVNGYLIPKGTQILINAYAIGRDPSIW 402 Query: 406 EDPLTFNPDRFGPGAPKPR---FTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRL 462 DP TF+P+RF + + PF G R C G A + + A L+ +++L Sbjct: 403 TDPETFDPERFLDNKIDFKGQDYELLPFGSGRRVCPGMPLATRILHMATATLVHNFDWKL 462 >6AYB-A nrPDB Length = 466 Score = 119 bits (297), Expect = 4e-27, Method: Compositional matrix adjust. Identities = 105/447 (23%), Positives = 208/447 (46%), Gaps = 46/447 (10%) Query: 36 PPRPSFLLGHLPCF--WKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESV 93 PPR L+ ++ F + K+ V +D +KKYG V + K + P+ + Sbjct: 12 PPRVPNLIPYVGSFVSFAKNPV------QFIIDNSKKYGDVFTATILGKEMTFLNHPKIL 65 Query: 94 KKFLMSTKYNKDS--KMYRALQTVFGERLFGQGLVSECN-YERWHKQRRVIDLAFSRSSL 150 F +T N+ S +YR ++ VFG G+V + + ER +Q + + + + Sbjct: 66 DTFFKATD-NELSLRDVYRFMRPVFG-----TGVVYDADSTERMMEQVKFVSSGLTTARF 119 Query: 151 VSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKP 210 ++ F ++ V+ L + M D++ +TA ++ G E L ++K Sbjct: 120 RVFVDIFEDEIAHKVKELGPEGTVDVAELMADLIIFTA----SRCLLGDEVRQYL-SEKN 174 Query: 211 LSQAVKLMLEGITASRNTLAKFLPG----KRKQLREVRESIRFLRQVGRDWVQRRREALK 266 L + + +GI+ L+ F P KR + R+ + ++ ++ + +RRE K Sbjct: 175 LGKLYHDIDDGISP----LSFFYPSLPAPKRDKARKA------VGEIFQELLDKRREEHK 224 Query: 267 RG-----EEVPADILTQIL--KAEEGAQ-DDEGLLDNFVTFFIAGHETSANHLAFTVMEL 318 + +E D++ +L K ++G + D + + AG TS+ ++T+M + Sbjct: 225 KHPERLLDESKMDVVDHLLTQKYKDGQELTDVHRIGILIAGLFAGQHTSSITSSWTLMNV 284 Query: 319 SRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEET 378 +++ +++ E +E++GS + LD++ + ++ YL +KE+LR+YPP R+ + Sbjct: 285 ISNKKVLEKVRKEQEEIMGSDKVLDYDKVMKMDYLEACMKEALRMYPPLIMIMRMARKPR 344 Query: 379 LIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTY--FPFSLGHRS 436 + +P L+ S V GR + +P F+P+R +F Y PF G Sbjct: 345 ECEQYIIPKGNILVVSPSVAGRCTDTYTNPDVFDPERLTERKEHEKFKYGAVPFGAGRHK 404 Query: 437 CIGQQFAQMEVKVVMAKLLQRLEFRLV 463 CIG+ FA ++VK +++ LL+ + + Sbjct: 405 CIGENFALLQVKSIISILLRYFDMEYI 431 >4KPA-A nrPDB Length = 494 Score = 113 bits (283), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 97/423 (22%), Positives = 194/423 (45%), Gaps = 26/423 (6%) Query: 68 AKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVS 127 A + G + + + + ++S +K+ ++++K+ + +AL+ F G GL + Sbjct: 57 ADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKN--LSQALK--FVRDFAGDGLFT 112 Query: 128 ECNYER-WHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTY 186 +E+ W K ++ +FS+ ++ + A QLV+ E + + + + + +T Sbjct: 113 SWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWE-RLNADEHIEVPEDMTR 171 Query: 187 TAMDILAKAAFGMETSMLLGAQ-KPLSQAVKLMLEGITASRNTLAKFLPGK---RKQLRE 242 +D + F + Q P + M+ + + N L + P + R+ Sbjct: 172 LTLDTIGLCGFNYRFNSFYRDQPHPF---ITSMVRALDEAMNKLQRANPDDPAYDENKRQ 228 Query: 243 VRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQ----DDEGLLDNFVT 298 +E I+ + + + R+ + ++ + D+LT +L ++ DDE + +T Sbjct: 229 FQEDIKVMNDLVDKIIADRKASGEQSD----DLLTHMLNGKDPETGEPLDDENIRYQIIT 284 Query: 299 FFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLK 358 F IAGHET++ L+F + L + P ++ + E V+ ++ + +L+Y+ VL Sbjct: 285 FLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDP-VPSYKQVKQLKYVGMVLN 343 Query: 359 ESLRLYPPAWGTFRLLEEETLIDGVRVP---GNTPLLFSTYVMGRMDTYFEDPLTFNPDR 415 E+LRL+P A F L +E + G P G+ ++ + + +D F P+R Sbjct: 344 EALRLWPTA-PAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPER 402 Query: 416 FGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQAT 475 F + P+ + PF G R+CIGQQFA E +V+ +L+ +F ++E T Sbjct: 403 FENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLT 462 Query: 476 LKP 478 LKP Sbjct: 463 LKP 465 >3K9V-A nrPDB Length = 482 Score = 107 bits (266), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 108/470 (22%), Positives = 193/470 (41%), Gaps = 26/470 (5%) Query: 33 IPGPPRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPES 92 +PGP L L FWK G + D ++ KKYG + R+ + SV + SP Sbjct: 26 LPGPTNWPLLGSLLEIFWKG---GLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHLGSPSL 82 Query: 93 VKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRS-SLV 151 ++ + + + + R GL+ + W + R + ++ Sbjct: 83 LEALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMI-LEGQEWQRVRSAFQKKLMKPVEIM 141 Query: 152 SLMETFNEKAEQLVEILEAKAD--GQTPVSMQDMLTYTAMDI---LAKAAFGMETSMLLG 206 L + NE +E ++ D G+ P ++ ++ I L + FG+ Sbjct: 142 KLDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGL------- 194 Query: 207 AQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRR----- 261 QK + + I +T K + + + + + + D + + Sbjct: 195 LQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCI 254 Query: 262 REALKRGEEVP-ADILTQILKAEEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSR 320 L+R + P AD L I + + ++ + L +A ET+AN L + + LSR Sbjct: 255 DNRLQRYSQQPGADFLCDIYQQDHLSKKE--LYAAVTELQLAAVETTANSLMWILYNLSR 312 Query: 321 QPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLI 380 P+ RL EV V+ + EDL + YL LKES+RL P T R L++ T++ Sbjct: 313 NPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVL 372 Query: 381 DGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPR-FTYFPFSLGHRSCIG 439 +P T L +T V+G + FED F P+R+ K F + PF +G R CIG Sbjct: 373 GEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIG 432 Query: 440 QQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPVLCTLRPR 489 ++ A++++ + + ++Q+ + + + L P + RPR Sbjct: 433 RRLAELQLHLALCWIIQKYDIVATDNEPVEMLHLGILVPSRELPIAFRPR 482 >2VE3-A nrPDB Length = 444 Score = 105 bits (262), Expect = 5e-23, Method: Compositional matrix adjust. Identities = 105/423 (24%), Positives = 188/423 (44%), Gaps = 40/423 (9%) Query: 69 KKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSE 128 +++GP+ + +F K +VI S +FL + K+ + ++A + L G ++ Sbjct: 41 QQFGPIFKTRLFGK-NVIFISGALANRFL----FTKEQETFQATWPLSTRILLGPNALAT 95 Query: 129 CNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTA 188 E +R+++ AF L ++++ K + +V+ + V L Sbjct: 96 QMGEIHRSRRKILYQAF----LPRTLDSYLPKMDGIVQGYLEQWGKANEVIWYPQLRRMT 151 Query: 189 MDILAKAAFGMETSMLLGAQKP-LSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESI 247 D+ A G + S Q P L + ++G+ + L L GK ++ R + Sbjct: 152 FDVAATLFMGEKVS-----QNPQLFPWFETYIQGLFSLPIPLPNTLFGKSQRARAL---- 202 Query: 248 RFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDEG-------LLDNFVTFF 300 L ++ + + + R+ EE IL A+DD L D + Sbjct: 203 -LLAELEK--IIKARQQQPPSEEDALGILL-------AARDDNNQPLSLPELKDQILLLL 252 Query: 301 IAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKES 360 AGHET + L+ + L + +I R++ E +++ S+ L E L ++ YL QVL+E Sbjct: 253 FAGHETLTSALSSFCLLLGQHSDIRERVRQEQNKLQLSQE-LTAETLKKMPYLDQVLQEV 311 Query: 361 LRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGA 420 LRL PP G FR L ++ G P + + + DP F+P+RF P Sbjct: 312 LRLIPPVGGGFRELIQDCQFQGFHFPKGWLVSYQISQTHADPDLYPDPEKFDPERFTPDG 371 Query: 421 P---KPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLK 477 P F + PF G R C+G++FA++E+K+ +L+Q+ ++ L+PGQ L + + Sbjct: 372 SATHNPPFAHVPFGGGLRECLGKEFARLEMKLFATRLIQQFDWTLLPGQNLELVVTPSPR 431 Query: 478 PLD 480 P D Sbjct: 432 PKD 434 >1WIY-A nrPDB Length = 389 Score = 105 bits (261), Expect = 6e-23, Method: Compositional matrix adjust. Identities = 114/434 (26%), Positives = 177/434 (40%), Gaps = 73/434 (16%) Query: 63 VFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFG 122 V L+W + + P + + + ++ PE V+ L++ K + YRAL RL G Sbjct: 23 VLLEWGRAH-PRLFLPLPRFPLALIFDPEGVEGALLAEGTTKATFQYRALS-----RLTG 76 Query: 123 QGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQD 182 +GL+++ + W + R+ + F S+ E E+A + G+ + Sbjct: 77 RGLLTDWG-KSWKEARKALKDPFLPKSVRGYREAMEEEAWAFF----GEWRGEERDLDHE 131 Query: 183 MLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLRE 242 ML + + +L +A FG S L A+K + + +R+ LA + R+ Sbjct: 132 MLALS-LRLLGRALFGKPLSPSLA-----EHALKALDRIMAQTRSPLALLDLAAEARFRK 185 Query: 243 VRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDEGLLDNFVTFFIA 302 R ++ R EAL I+ E L VT +A Sbjct: 186 DRGAL-----------YREAEAL-------------IVHPPLSHLPRERALSEAVTLLVA 221 Query: 303 GHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLR 362 GHET A+ L ++ + LS +P+ R+ + +E+LR Sbjct: 222 GHETVASALTWSFLLLSHRPDWQKRVAESEEAA------------------LAAFQEALR 263 Query: 363 LYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPK 422 LYPPAW R LE L+ R+P T L+ S YV R+ YF + F P+RF Sbjct: 264 LYPPAWILTRRLERPLLLGEDRLPQGTTLVLSPYVTQRL--YFPEGEAFQPERFLAERGT 321 Query: 423 PRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPV 482 P YFPF LG R C+G+ FA +E +V+ +R +P R Q Sbjct: 322 PSGRYFPFGLGQRLCLGRDFALLEGPIVLRAFFRRFRLDPLPFPRVLAQ----------- 370 Query: 483 LCTLRPRGWQPAPP 496 TLRP G PA P Sbjct: 371 -VTLRPEGGLPARP 383 >4R20-A nrPDB Length = 486 Score = 102 bits (255), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 103/418 (24%), Positives = 189/418 (45%), Gaps = 33/418 (7%) Query: 63 VFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFG 122 +F + +YGP+ + +++V+ V++ L+ + + + + L Sbjct: 44 LFTQLSSQYGPLFGLYAGPHLTLVVSEIGLVREVLL-----QRGREFAGRPKMVTTDLLT 98 Query: 123 QG--LVSECNYE-RWHKQRRVIDLAFSRSSLVS--LMETFNEKAEQLVEILEAKADGQTP 177 QG ++ +Y W RR++ +F+ S L E A+ L E L+A + Sbjct: 99 QGGKDIAFADYSPLWKNHRRLVHSSFTLFGEGSNKLQTIVQEAADSLCEELQACRGQSSD 158 Query: 178 VSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGI--TASRNTLAKFLPG 235 +S+ +L +++ + F S P Q V +GI T +R L P Sbjct: 159 LSV--VLMRAVTNVICRLVF----SSSYQPSDPELQTVIQYNDGIVQTIARGGLVDIFPW 212 Query: 236 KR----KQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEE---GAQD 288 R K L+ ++E + Q+ + +++L GE P D+L +L ++ G D Sbjct: 213 LRIFPNKDLKRLKECVSIRDQLLYKKLLEHKKSLTPGE--PRDLLDALLIGQQRGSGGAD 270 Query: 289 D---EGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFE 345 D + +L F AG ET++ L +T+ L P++ R+QAE+DE +G R Sbjct: 271 DITEDHVLMTAAEAFGAGVETTSTTLLWTIAFLLHHPQLQERVQAELDECVGVDRPPCLS 330 Query: 346 DLGRLQYLSQVLKESLRLYPPAWGTF-RLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTY 404 D L L VL E +R+ P + + ++T + G VP T +L + + + + Sbjct: 331 DRPHLPLLDAVLCEVMRIRPVSPILIPHVAMQDTSLGGHSVPKGTRVLVNMWAIHHDPKH 390 Query: 405 FEDPLTFNPDRF--GPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEF 460 ++ P FNP+RF G K + ++ PF G R C+G+ A++E+ + +++ LQR F Sbjct: 391 WDQPEQFNPERFLEPSGKKKTQSSFLPFGAGPRVCVGESLARIELFLFVSRPLQRFSF 448 >5E58-A nrPDB Length = 493 Score = 99.0 bits (245), Expect = 5e-21, Method: Compositional matrix adjust. Identities = 110/421 (26%), Positives = 189/421 (44%), Gaps = 40/421 (9%) Query: 62 DVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLF 121 + F+ +KYG V V++ + V++ E++++ L+ ++ R V + Sbjct: 53 NSFMRIREKYGDVFTVHLGPRPVVMLYGTEAIREALVD---QAEAFSGRGTIAVIKPVIG 109 Query: 122 GQGLVSECNYERWHKQRRVIDLAFSRSSLV---SLMETFNEKAEQLVEILEAKADGQTPV 178 G++ N ERW RR LA R + S+ + E+A+ LVE L+ K+ G P+ Sbjct: 110 DYGMIF-SNGERWKVLRR-FSLATMRDFGMGKRSVEDRIQEEAQCLVEELQ-KSQG-APL 165 Query: 179 SMQDMLTYTAMDILAKAAFG----METSMLLGAQKPLSQAVKLMLE---GITASRNTLAK 231 + +I+ FG + L + LM + + K Sbjct: 166 DPTFLFQCITANIICSIVFGERYDYKDRQFLRLLDLFYRTFSLMSSFSSQVFELFSGFMK 225 Query: 232 FLPGKRKQL-REVRESIRFLRQVGRDWVQRRREALKRGEEVPADIL-TQILKAEEGAQDD 289 + PG +Q+ R ++E + ++ Q V++ R L P D + T +L+ E+ + Sbjct: 226 YFPGAHRQITRNLQEILDYVGQ----SVEKHRATLDPSN--PRDFIDTYLLRMEKEKSNQ 279 Query: 290 ------EGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLD 343 + LL + ++ F AG ET++ L + + + + P + ++Q E+D+VIGS R Sbjct: 280 HTEFHHQNLLISVLSLFFAGTETTSTTLRYGFLLMLKYPHVAEKVQKEIDQVIGSHRLPT 339 Query: 344 FEDLGRLQYLSQVLKESLRLYPPA-WGTFRLLEEETLIDGVRVPGNT---PLLFSTYVMG 399 ED ++ Y V+ E R A G + ++TL G +P NT P+L S Sbjct: 340 LEDRTKMPYTDAVIHEIQRFSDLAPIGAPHKVTKDTLFRGYLLPKNTEVYPILSSAL--- 396 Query: 400 RMDTYFEDPLTFNPDRF--GPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQR 457 YFE P TFNPD F GA K + PFS+G R C+G+ A+ E+ + +LQ Sbjct: 397 HDPQYFEQPGTFNPDHFLDANGALKKSEAFMPFSIGKRICLGEGIARNELFLFFTTILQN 456 Query: 458 L 458 Sbjct: 457 F 457 >3JUS-A nrPDB Length = 461 Score = 97.4 bits (241), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 96/440 (21%), Positives = 186/440 (42%), Gaps = 28/440 (6%) Query: 35 GPPRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWA-KKYGPVVRVNVFHKTSVIVTSPESV 93 G P ++ +P G ++ FL+ A +KYGPV + KT + ++ Sbjct: 9 GVKSPPYIFSPIPFLGHAIAFGKSPIE--FLENAYEKYGPVFSFTMVGKTFTYLLGSDAA 66 Query: 94 KKFLMSTKYNKDSK-MYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVS 152 S + +++ +Y L T +FG+G+ + + +Q++++ + + Sbjct: 67 ALLFNSKNEDLNAEDVYSRLTT----PVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQ 122 Query: 153 LMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLS 212 + ++ ++ E + ++ +++ TA L G E + L+ Sbjct: 123 HVSIIEKETKEYFESWGESGEKNVFEALSELIILTASHCL----HGKEI------RSQLN 172 Query: 213 QAVKLMLEGITASRNTLAKFLPG--KRKQLREVRESIRFLRQVGRDWVQRRREALKRGEE 270 + V + + + A LPG R + R ++ + +Q+RR++ ++ ++ Sbjct: 173 EKVAQLYADLDGGFSHAAWLLPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQSQEKIDD 232 Query: 271 VPADILTQILKAEEGAQDDE--GLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARL 328 + +L K DDE G+L + +AG TS+ A+ L+R + + Sbjct: 233 ILQTLLDATYKDGRPLTDDEVAGML---IGLLLAGQHTSSTTSAWMGFFLARDKTLQKKC 289 Query: 329 QAEVDEVIGSKRY-LDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPG 387 E V G L ++ L L L + +KE+LRL PP R+ + G +P Sbjct: 290 YLEQKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVAGYTIPP 349 Query: 388 NTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKP--RFTYFPFSLGHRSCIGQQFAQM 445 + S V R+ + + L FNPDR+ P +F Y PF G CIG+ FA + Sbjct: 350 GHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYV 409 Query: 446 EVKVVMAKLLQRLEFRLVPG 465 ++K + + +L+ EF L+ G Sbjct: 410 QIKTIWSTMLRLYEFDLIDG 429 >6CR2-A nrPDB Length = 477 Score = 97.4 bits (241), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 97/433 (22%), Positives = 184/433 (42%), Gaps = 48/433 (11%) Query: 64 FLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNK--DSKMYRALQTVFGERLF 121 F D KYG + + K + + + F+++ K ++Y L T +F Sbjct: 30 FFDCRAKYGDIFTFILLGKKTTVYLGTKG-NDFILNGKLRDVCAEEVYSPLTT----PVF 84 Query: 122 GQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEA----KADGQTP 177 G+ +V +C + +Q++ + + +L S + ++ E V+ A K Sbjct: 85 GRHVVYDCPNAKLMEQKKFVKYGLTSDALRSYVPLITDEVESFVKNSPAFQGHKGVFDVC 144 Query: 178 VSMQDMLTYTAMDIL----AKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFL 233 ++ ++ YTA L ++ F + L + ML N K Sbjct: 145 KTIAEITIYTASRSLQGKEVRSKFDSTFAELYHNLDMGFAPINFMLPWAPLPHNR--KRD 202 Query: 234 PGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDEGLL 293 +RK E I+ RQ G + K E++ ++++ + K D+E + Sbjct: 203 AAQRKLTETYMEIIKARRQAG---------SKKDSEDMVWNLMSCVYKNGTPVPDEE-IA 252 Query: 294 DNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRY-LDFEDLGRLQY 352 + +AG +S++ ++ V+ L+ +P+I+ L E V+GS L +++L +L Sbjct: 253 HMMIALLMAGQHSSSSTASWIVLRLATRPDIMEELYQEQIRVLGSDLPPLTYDNLQKLDL 312 Query: 353 LSQVLKESLRLYPPAWGTFRLLEEETLIDGVR--VPGNTPLLFSTYVMGRMDTYFEDPLT 410 ++V+KE+LRL+ P R ++ +DG +P + +L S V R + +F +PL Sbjct: 313 HAKVIKETLRLHAPIHSIIRAVKNPMAVDGTSYVIPTSHNVLSSPGVTARSEEHFPNPLE 372 Query: 411 FNPDR------------------FGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMA 452 +NP R +G + Y PF G CIG+QFA +++ + A Sbjct: 373 WNPHRWDENIAASAEDDEKVDYGYGLVSKGTNSPYLPFGAGRHRCIGEQFAYLQLGTITA 432 Query: 453 KLLQRLEFRLVPG 465 L++ FR +PG Sbjct: 433 VLVRLFRFRNLPG 445 >2W0A-A nrPDB Length = 455 Score = 96.7 bits (239), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 63/196 (32%), Positives = 100/196 (51%), Gaps = 8/196 (4%) Query: 274 DILTQILKAEEGA---QDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQA 330 D+L + KAE G DE + F++ AGH TS+ ++T++EL R + A + Sbjct: 227 DVLIAV-KAETGTPRFSADE-ITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVID 284 Query: 331 EVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTP 390 E+DE+ G R + F L ++ L VLKE+LRL+PP R+ + E + G R+ Sbjct: 285 ELDELYGDGRSVSFHALRQIPQLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDL 344 Query: 391 LLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKP---RFTYFPFSLGHRSCIGQQFAQMEV 447 + S + R+ F DP F P R+ + R+T+ PF G C+G FA M++ Sbjct: 345 VAASPAISNRIPEDFPDPHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQI 404 Query: 448 KVVMAKLLQRLEFRLV 463 K + + LL+ EF + Sbjct: 405 KAIFSVLLREYEFEMA 420 >5E0E-A nrPDB Length = 463 Score = 96.7 bits (239), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 109/418 (26%), Positives = 180/418 (43%), Gaps = 48/418 (11%) Query: 69 KKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSE 128 +KYG V V++ + V++ E++++ L+ ++ R V G G+V Sbjct: 32 EKYGDVFTVHLGPRPVVMLYGTEAIREALVD---QAEAFSGRGTIAVVEPIFRGYGVVF- 87 Query: 129 CNYERWHKQRR-----VIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDM 183 N ERW RR + D + S+ E E+A LVE E + P+ + Sbjct: 88 ANGERWKALRRFSLVTMRDFGMGKRSV---EERIQEEARCLVE--EFRKSQGAPLDPTFL 142 Query: 184 LTYTAMDILAKAAFGMETSM-------LLGAQKPLSQAVKLMLEGITASRNTLAKFLPGK 236 +I+ FG LL + + + K+ PG Sbjct: 143 FQCITANIICSIVFGERFDYKDHQFLRLLYLFYQSFSLISSFSSQVFELFSGFLKYFPGT 202 Query: 237 RKQL-REVRESIRFLRQVGRDWVQRRREALKRGEEVPADIL-TQILKAEEGAQ------D 288 +Q+ R ++E + ++ Q V++ R L P D + T +L+ E+ D Sbjct: 203 HRQISRNLQEILDYIGQ----SVEKHRATLDPSH--PRDFIDTYLLRMEKEKSNQHTEFD 256 Query: 289 DEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLG 348 + L+ + ++ F AG ETS+ L + + + + P + ++Q E+D+VIGS R ED Sbjct: 257 HQNLVISVLSLFFAGTETSSTTLRYGFLLMLKYPHVAEKVQKEIDQVIGSHRLPTLEDRT 316 Query: 349 RLQYLSQVLKESLR---LYPPAWGTFRLLEEETLIDGVRVPGNT---PLLFSTYVMGRMD 402 ++ Y V+ E R L P G + ++TL G +P NT P+L S Sbjct: 317 KMPYTEAVIYEIQRFSDLIP--IGVPHKVTKDTLFRGYLLPKNTEVYPILSSAL---HDP 371 Query: 403 TYFEDPLTFNPDRF--GPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRL 458 YFE P TFNPD F GA K + PFS+G R C+G+ A+ E+ + +LQ Sbjct: 372 QYFEQPDTFNPDHFLDANGALKKSEAFMPFSIGKRICLGEGIARNELFLFFTTILQNF 429 >6B82-A nrPDB Length = 509 Score = 96.3 bits (238), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 102/432 (23%), Positives = 194/432 (44%), Gaps = 44/432 (10%) Query: 64 FLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRAL-QTVFGERLFG 122 F D KKYG + + + +IV + K+ L+ K K++ +TV + L Sbjct: 50 FQDLQKKYGDLYSLMMGSHKLLIVNNHHHAKEILI-----KKGKIFAGRPRTVTTDLLTR 104 Query: 123 QGL-VSECNYER-WHKQRRVIDLA---FSRSSLVSLMETFNEKAEQLVEILEAKADGQTP 177 G ++ +Y W R+++ A F S VS+ + +A + E+L + + Sbjct: 105 DGKDIAFADYSSTWKFHRKMVHGALCMFGEGS-VSIEKIICREASSMCEVLTESQN--SA 161 Query: 178 VSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPG-- 235 V + LT +++ F + + Q + +++ T ++++L P Sbjct: 162 VDLGPELTRAVTNVVCALCFNSSYKRGDAEFESMLQYSQGIVD--TVAKDSLVDIFPWLQ 219 Query: 236 --KRKQLREVRESIRFLRQVGRDWVQRRREALK--RGEEVPADILTQILKAEEGAQD--- 288 K LR +R+ I ++ +Q++ E K + V D+L +L+A+ +++ Sbjct: 220 IFPNKDLRILRQCISIRDKL----LQKKYEEHKVTYSDNVQRDLLDALLRAKRSSENNNS 275 Query: 289 ---DEGLLDNFV-----TFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKR 340 D GL ++ V F AG ET+ L +++ L P++ ++Q E+D IG +R Sbjct: 276 STRDVGLTEDHVLMTVGEIFGAGVETTTTTLKWSIAYLVHNPQVQRKIQEELDSKIGKER 335 Query: 341 YLDFEDLGRLQYLSQVLKESLRLYP--PAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVM 398 + D G L YL + E +R+ P P L++ + + V T ++ + + + Sbjct: 336 HPQLSDRGNLPYLEATICEVMRIRPVSPLLIPHVALQDSS-VGEYTVQKGTRVVINMWSL 394 Query: 399 GRMDTYFEDPLTFNPDRF----GPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKL 454 + +++P F+P RF G G P +Y PF G R C+G+ A+ME+ + +A + Sbjct: 395 HHDEKEWKNPELFDPGRFLNEEGDGLCCPSGSYLPFGAGVRVCLGEALAKMELFLFLAWI 454 Query: 455 LQRLEFRLVPGQ 466 LQR + GQ Sbjct: 455 LQRFTLEMPTGQ 466 >4H1N-A nrPDB Length = 479 Score = 96.3 bits (238), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 117/449 (26%), Positives = 193/449 (42%), Gaps = 48/449 (10%) Query: 36 PPRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKK 95 PP PS LP ++ + L FL +KYG V V + + V++ +++++ Sbjct: 12 PPGPS----PLPVLGNLLQMDRKGLLRSFLRLREKYGDVFTVYLGSRPVVVLCGTDAIRE 67 Query: 96 FLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLV---S 152 L+ ++ R V G G++ N ERW RR LA R + S Sbjct: 68 ALVD---QAEAFSGRGKIAVVDPIFQGYGVIF-ANGERWRALRR-FSLATMRDFGMGKRS 122 Query: 153 LMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAM--DILAKAAFGMETSM------- 203 + E E+A LVE L K+ G + + L + ++ +I+ FG Sbjct: 123 VEERIQEEARCLVEELR-KSKGAL---LDNTLLFHSITSNIICSIVFGKRFDYKDPVFLR 178 Query: 204 LLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQL-REVRESIRFLRQVGRDWVQRRR 262 LL + + + K+ PG +Q+ R ++E F+ Q V++ R Sbjct: 179 LLDLFFQSFSLISSFSSQVFELFSGFLKYFPGTHRQIYRNLQEINTFIGQ----SVEKHR 234 Query: 263 EALKRGEEVPADIL-TQILKAEEGAQD------DEGLLDNFVTFFIAGHETSANHLAFTV 315 L P D + +L+ E+ D + L+ ++ F AG ET++ L + Sbjct: 235 ATLDPSN--PRDFIDVYLLRMEKDKSDPSSEFHHQNLILTVLSLFAAGTETTSTTLRYGF 292 Query: 316 MELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYP-PAWGTFRLL 374 + + + P + R+Q E+++VIGS R +D ++ Y V+ E RL +G + Sbjct: 293 LLMLKYPHVTERVQKEIEQVIGSHRPPALDDRAKMPYTDAVIHEIQRLGDLIPFGVPHTV 352 Query: 375 EEETLIDGVRVPGNT---PLLFSTYVMGRMDTYFEDPLTFNPDRF--GPGAPKPRFTYFP 429 ++T G +P NT P+L S R YFE P TFNP F GA K + P Sbjct: 353 TKDTQFRGYVIPKNTEVFPVLSSALHDPR---YFETPNTFNPGHFLDANGALKRNEGFMP 409 Query: 430 FSLGHRSCIGQQFAQMEVKVVMAKLLQRL 458 FSLG R C+G+ A+ E+ + +LQ Sbjct: 410 FSLGKRICLGEGIARTELFLFFTTILQNF 438 >5UYS-A nrPDB Length = 494 Score = 96.3 bits (238), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 101/430 (23%), Positives = 185/430 (43%), Gaps = 38/430 (8%) Query: 60 LQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGER 119 + + F KKYGP+ V + KT+VIV + K+ L+ + + A + Sbjct: 31 MHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNN 90 Query: 120 LFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVS 179 G + + H++ + A + L + ++ L ++L A +GQ+ + Sbjct: 91 RKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDML-ATHNGQS-ID 148 Query: 180 MQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGI--TASRNTLAKFLPGKR 237 + + ++++ F TS G P ++ EGI S+++L +P + Sbjct: 149 ISFPVFVAVTNVISLICFN--TSYKNG--DPELNVIQNYNEGIIDNLSKDSLVDLVPWLK 204 Query: 238 KQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQIL--------KAEEGA--- 286 + E ++ ++ D + + E K E+ +D +T +L ++ G Sbjct: 205 IFPNKTLEKLKSHVKIRNDLLNKILENYK--EKFRSDSITNMLDTLMQAKMNSDNGNAGP 262 Query: 287 -QDDEGLLDNFV-----TFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKR 340 QD E L DN + F AG ET+ + + +T+ L P++ +L E+D+ +G R Sbjct: 263 DQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSR 322 Query: 341 YLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDG----VRVPGNTPLLFSTY 396 D RL L ++E LRL P A L+ + +D V T ++ + + Sbjct: 323 TPTISDRNRLLLLEATIREVLRLRPVA---PMLIPHKANVDSSIGEFAVDKGTEVIINLW 379 Query: 397 VMGRMDTYFEDPLTFNPDRF----GPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMA 452 + + + P F P+RF G P +Y PF G RSCIG+ A+ E+ ++MA Sbjct: 380 ALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMA 439 Query: 453 KLLQRLEFRL 462 LLQR + + Sbjct: 440 WLLQRFDLEV 449 >2PG7-A nrPDB Length = 476 Score = 95.5 bits (236), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 113/462 (24%), Positives = 201/462 (43%), Gaps = 60/462 (12%) Query: 36 PPRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKK 95 PP P+ LP ++ + + + +++YGPV +++ + V++ ++V++ Sbjct: 12 PPGPT----PLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVRE 67 Query: 96 FLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVS--- 152 L+ + R Q F G G+V N ER KQ R +A R V Sbjct: 68 ALVD---QAEEFSGRGEQATFDWVFKGYGVVF-SNGERA-KQLRRFSIATLRDFGVGKRG 122 Query: 153 LMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETS---------- 202 + E E+A L++ L + G + L+ T ++++ FG Sbjct: 123 IEERIQEEAGFLIDAL--RGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLL 180 Query: 203 -MLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRR 261 M+LG + S + + E ++ + K LPG ++Q ++ + + D++ ++ Sbjct: 181 RMMLGIFQFTSTSTGQLYEMFSS----VMKHLPGPQQQAFQLLQGLE-------DFIAKK 229 Query: 262 REALKR--GEEVPADILTQIL---KAEEGAQDDEGLLDNFVT----FFIAGHETSANHLA 312 E +R P D + L + EE + E L N V F+ G ET + L Sbjct: 230 VEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLQLFVGGTETVSTTLR 289 Query: 313 FTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLR---LYPPAWG 369 + + L + PE+ A++ E+D VIG R FED ++ Y+ V+ E R + P + Sbjct: 290 YGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLA 349 Query: 370 TFRLLEEETLIDGVRVPGNT---PLLFSTYVMGRMDTYFEDPLTFNPDRF--GPGAPKPR 424 R ++++T +P T P+L S R ++F +P FNP F G K Sbjct: 350 --RRVKKDTKFRDFFLPKGTEVYPMLGSVL---RDPSFFSNPQDFNPQHFLNEKGQFKKS 404 Query: 425 FTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQ 466 + PFS+G R+C G+ A+ME+ + ++Q FRL Q Sbjct: 405 DAFVPFSIGKRNCFGEGLARMELFLFFTTVMQ--NFRLKSSQ 444 >3DL9-A nrPDB Length = 479 Score = 94.0 bits (232), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 69/253 (27%), Positives = 119/253 (47%), Gaps = 22/253 (8%) Query: 253 VGRDWVQR--RREALKRGEEVPADILTQILKAEEGAQDD-------EGLLDNFVTFFIAG 303 V D++ R + ++ R ++P + L + ++D E L+ + IAG Sbjct: 226 VVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAG 285 Query: 304 HETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRL 363 ET+ N L + ++ ++ P I ++Q E+D ++G ++D ++ Y VL E LR Sbjct: 286 TETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRF 345 Query: 364 YPPA-WGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRF--GPGA 420 G F E+ ++ G +P T ++ + Y + + Y+ DP F+P+RF G Sbjct: 346 CNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGY 405 Query: 421 PKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFR----LVPG--QRFGLQEQA 474 + PFSLG R C+G+ A+ME+ + LLQR LVP R G+ Sbjct: 406 FAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGM---- 461 Query: 475 TLKPLDPVLCTLR 487 TL+P ++C R Sbjct: 462 TLQPQPYLICAER 474 >2NNH-A nrPDB Length = 476 Score = 90.9 bits (224), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 107/454 (23%), Positives = 184/454 (40%), Gaps = 48/454 (10%) Query: 36 PPRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKK 95 PP P+ LP ++ + + F +++K YGPV V V+ E+VK+ Sbjct: 12 PPGPT----PLPIIGNMLQIDVKDICKSFTNFSKVYGPVFTVYFGMNPIVVFHGYEAVKE 67 Query: 96 FLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLV---- 151 L+ N + R + G G++S N +RW + RR FS ++L Sbjct: 68 ALID---NGEEFSGRGNSPISQRITKGLGIISS-NGKRWKEIRR-----FSLTTLRNFGM 118 Query: 152 ---SLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAF----GMETSML 204 S+ + E+A LVE E + +P +L +++ F + Sbjct: 119 GKRSIEDRVQEEAHCLVE--ELRKTKASPCDPTFILGCAPCNVICSVVFQKRFDYKDQNF 176 Query: 205 LGAQKPLSQAVKLMLEGITASRNT---LAKFLPGKRKQLREVRESIRFLRQVGRDWVQRR 261 L K ++ +++ N L PG + V +++ R R+ V+ Sbjct: 177 LTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNK---VLKNVALTRSYIREKVKEH 233 Query: 262 REALKRGEEVPADILTQILKAEEGAQDD-------EGLLDNFVTFFIAGHETSANHLAFT 314 + +L P D + L E +D+ E L+ F+AG ET++ L + Sbjct: 234 QASLDVNN--PRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYG 291 Query: 315 VMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLR---LYPPAWGTF 371 ++ L + PE+ A++Q E+D VIG R +D + Y V+ E R L P G Sbjct: 292 LLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVP--TGVP 349 Query: 372 RLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRF--GPGAPKPRFTYFP 429 + +T +P T ++ + D F +P F+P F G K + P Sbjct: 350 HAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYFMP 409 Query: 430 FSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLV 463 FS G R C G+ A+ME+ + + +LQ + V Sbjct: 410 FSAGKRICAGEGLARMELFLFLTTILQNFNLKSV 443 >4R1Z-A nrPDB Length = 439 Score = 89.7 bits (221), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 85/359 (23%), Positives = 162/359 (45%), Gaps = 36/359 (10%) Query: 134 WHKQRRVIDLA---FSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMD 190 W R+++ A F S VS+ + +A + E+L + + V + LT + Sbjct: 54 WKFHRKMVHGALCMFGEGS-VSIEKIICREASSMCEVLTESQN--SAVDLGPELTRAVTN 110 Query: 191 ILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPG----KRKQLREVRES 246 ++ F + + Q + +++ T ++++L P K L +R+ Sbjct: 111 VVCALCFNSSYKRGDAEFESMLQYSQGIVD--TVAKDSLVDIFPWLQIFPNKDLTILRQC 168 Query: 247 IRFLRQVGRDWVQRRREALK--RGEEVPADILTQILKAEEGAQD------DEGLLDNFV- 297 I ++ +Q++ E K + V D+L +L+A+ +++ D GL ++ V Sbjct: 169 ISIRDKL----LQKKYEEHKVTYSDNVQRDLLDALLRAKRSSENNNSSTRDVGLTEDHVL 224 Query: 298 ----TFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYL 353 F AG ET+ L +++ L P++ ++Q E+D IG +R+ D G L YL Sbjct: 225 MTVGDIFGAGVETTTTVLKWSIAYLVHNPQVQRKIQEELDSKIGKERHPQLSDRGNLPYL 284 Query: 354 SQVLKESLRLYP--PAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTF 411 ++E LR+ P P L++ + + V T ++ + + + +++P F Sbjct: 285 EATIREVLRIRPVSPLLIPHVALQDSS-VGEYTVQKGTRVVINLWSLHHDKKEWKNPELF 343 Query: 412 NPDRF----GPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQ 466 +P RF G G P +Y PF G R C+G+ A+ME+ + +A +LQR + GQ Sbjct: 344 DPGRFLNEEGDGLCCPSGSYLPFGAGVRVCLGEALAKMELFLFLAWILQRFTLEMPTGQ 402 >3S79-A nrPDB Length = 503 Score = 89.0 bits (219), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 91/413 (22%), Positives = 177/413 (42%), Gaps = 36/413 (8%) Query: 67 WAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLV 126 + + YG +RV + + ++I++ S+ + Y+ LQ + + +G++ Sbjct: 77 YNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQCI---GMHEKGII 133 Query: 127 SECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTY 186 N E W R A S LV ++ E + ++ LE + V + +L Sbjct: 134 FNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRR 193 Query: 187 TAMDILAKAAFGMETSMLLGAQKPLSQ-AVKLMLEGITASRNTL----------AKFLPG 235 +D TS L + PL + A+ + ++G + L + Sbjct: 194 VMLD----------TSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKK 243 Query: 236 KRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEE-GAQDDEGLLD 294 K +++++++I L +RRR + + E D T+++ AE+ G E + Sbjct: 244 YEKSVKDLKDAIEVLIAE-----KRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQ 298 Query: 295 NFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLS 354 + IA +T + L F + +++ P + + E+ VIG +R + +D+ +L+ + Sbjct: 299 CILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIG-ERDIKIDDIQKLKVME 357 Query: 355 QVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPD 414 + ES+R P R E+ +IDG V T ++ + M R++ +F P F + Sbjct: 358 NFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLE-FFPKPNEFTLE 416 Query: 415 RFGPGAPKPRFTYF-PFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQ 466 F P + YF PF G R C G+ A + +K ++ LL+R + + GQ Sbjct: 417 NFAKNVP---YRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQ 466 >3IBD-A nrPDB Length = 476 Score = 89.0 bits (219), Expect = 5e-18, Method: Compositional matrix adjust. Identities = 105/425 (24%), Positives = 178/425 (41%), Gaps = 40/425 (9%) Query: 58 RVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFG 117 R L FL + +KYG V V++ + V++ E++++ L+ + A+ F Sbjct: 30 RGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFF 89 Query: 118 ERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLV-------SLMETFNEKAEQLVEIL-E 169 G G++ N RW RR FS +++ S+ E E+A+ L+E L + Sbjct: 90 R---GYGVIF-ANGNRWKVLRR-----FSVTTMRDFGMGKRSVEERIQEEAQCLIEELRK 140 Query: 170 AKADGQTPVSM-QDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNT 228 +K P + Q + I+ F + L Q L+ Sbjct: 141 SKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFEL 200 Query: 229 LAKFL---PGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQIL----K 281 + FL PG +Q+ + + I +G V++ RE L P D++ L K Sbjct: 201 FSGFLKHFPGAHRQVYKNLQEIN--AYIGHS-VEKHRETLD--PSAPRDLIDTYLLHMEK 255 Query: 282 AEEGAQDD---EGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGS 338 + A + + L N ++ F AG ET++ L + + + + P + R+ E+++VIG Sbjct: 256 EKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGP 315 Query: 339 KRYLDFEDLGRLQYLSQVLKESLR---LYPPAWGTFRLLEEETLIDGVRVPGNTPLLFST 395 R + D ++ Y V+ E R L P G ++ + T G +P +T + Sbjct: 316 HRPPELHDRAKMPYTEAVIYEIQRFSDLLP--MGVPHIVTQHTSFRGYIIPKDTEVFLIL 373 Query: 396 YVMGRMDTYFEDPLTFNPDRF--GPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAK 453 YFE P FNPD F GA K + PFSLG R C+G+ A+ E+ + Sbjct: 374 STALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTT 433 Query: 454 LLQRL 458 +LQ Sbjct: 434 ILQNF 438 >5W0C-A nrPDB Length = 477 Score = 86.7 bits (213), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 100/458 (21%), Positives = 187/458 (40%), Gaps = 60/458 (13%) Query: 36 PPRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKK 95 PP P+ LP ++G + + + +K YGPV + K V++ E+VK+ Sbjct: 13 PPGPT----PLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKE 68 Query: 96 FLMSTKYNKDSKMYRALQTVFGERLFGQGL------------VSECNYERWHKQRRVIDL 143 L+ GE G+G+ + N ++W + RR + Sbjct: 69 ALID----------------LGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLM 112 Query: 144 AFSRSSL--VSLMETFNEKAEQLVEIL-EAKADGQTPVSMQDMLTYTAM-DILAKAAFGM 199 + S+ + E+A LVE L + KA P + + I+ F Sbjct: 113 TLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDY 172 Query: 200 ETSMLLGAQKPLSQAVKLMLE---GITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRD 256 + L + L++ +K++ I + + + + PG +L + ++ F++ + Sbjct: 173 KDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLK---NVAFMKSYILE 229 Query: 257 WVQRRREALKRGEEVPADILTQILKAEEGAQDD-------EGLLDNFVTFFIAGHETSAN 309 V+ +E++ P D + L E + + E L + V F AG ET++ Sbjct: 230 KVKEHQESMDMNN--PQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTST 287 Query: 310 HLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLR---LYPP 366 L + ++ L + PE+ A++Q E++ VIG R +D + Y V+ E R L P Sbjct: 288 TLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPT 347 Query: 367 AWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRF---GPGAPKP 423 + + + +P T +L S + + F +P F+P F G K Sbjct: 348 SLP--HAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKS 405 Query: 424 RFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFR 461 ++ + PFS G R C+G+ A ME+ + + +LQ + Sbjct: 406 KY-FMPFSAGKRICVGEALAGMELFLFLTSILQNFNLK 442 >3QZ1-A nrPDB Length = 496 Score = 85.9 bits (211), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 102/419 (24%), Positives = 185/419 (44%), Gaps = 33/419 (7%) Query: 64 FLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQ 123 L +K GPV R+ + + V++ S ++++ ++ + + + +R Sbjct: 49 LLSLTQKLGPVYRLRLGLQEVVVLNSKRTIEEAMIRKWVDFAGRPQIPSYKLVSQRCQD- 107 Query: 124 GLVSECNYER-WHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQD 182 +S +Y W +++ A + S+ ++ ++ E + +A PV++Q Sbjct: 108 --ISLGDYSLLWKAHKKLTRSALLLGTRSSMEPWVDQLTQEFCERMRVQAGA--PVTIQK 163 Query: 183 MLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFL-----PGKR 237 + I+ FG + L+ A Q + + + + FL PG Sbjct: 164 EFSLLTCSIICYLTFGNKEDTLVHAFHDCVQDLMKTWDHWSIQILDMVPFLRFFPNPG-- 221 Query: 238 KQLREVRESIRFLRQVGRDWVQRRREALKRGE-EVPADILTQIL---KAEEG-AQDDEGL 292 L ++++I + ++R +E++ G+ D + Q + + EEG Q EG Sbjct: 222 --LWRLKQAIENRDHMVEKQLRRHKESMVAGQWRDMTDYMLQGVGRQRVEEGPGQLLEGH 279 Query: 293 LD-NFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIG---SKRYLDFEDLG 348 + + V FI G ET+A+ L++ V L PEI RLQ E+D +G S + ++D Sbjct: 280 VHMSVVDLFIGGTETTASTLSWAVAFLLHHPEIQRRLQEELDRELGPGASCSRVTYKDRA 339 Query: 349 RLQYLSQVLKESLRLYP--PAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFE 406 RL L+ + E LRL P P R ++ G +P ++ + +T +E Sbjct: 340 RLPLLNATIAEVLRLRPVVPLALPHRTTRPSSIF-GYDIPEGMVVIPNLQGAHLDETVWE 398 Query: 407 DPLTFNPDRF-GPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVP 464 P F PDRF PGA + F G R C+G+ A++E+ VV+A+LLQ F L+P Sbjct: 399 QPHEFRPDRFLEPGANP---SALAFGCGARVCLGESLARLELFVVLARLLQ--AFTLLP 452 >5VBU-A nrPDB Length = 476 Score = 85.5 bits (210), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 107/453 (23%), Positives = 197/453 (43%), Gaps = 42/453 (9%) Query: 64 FLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQ 123 L +K+GP+ R+++ + V++ S ++++ M K+ + L R + Sbjct: 30 LLGLTQKFGPIYRLHLGLQDVVVLNSKRTIEE-AMVKKWADFAGRPEPLTYKLVSRNYPD 88 Query: 124 GLVSECNYER-WHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQ--TPVSM 180 +S +Y W +++ A L+ + ++ EQL + + Q TPV++ Sbjct: 89 --LSLGDYSLLWKAHKKLTRSAL----LLGIRDSMEPVVEQLTQEFCERMRAQPGTPVAI 142 Query: 181 QDMLTYTAMDILAKAAFG---METSMLLGAQKPLSQAVKLMLEGITASRNTLA--KFLPG 235 ++ + I+ FG + +++ K + + +K + + +F P Sbjct: 143 EEEFSLLTCSIICYLTFGDKIKDDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFPN 202 Query: 236 KRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDEG---L 292 LR ++++I + +++ +E+L G+ D++ +L+ +EG L Sbjct: 203 P--GLRRLKQAIEKRDHIVEMQLRQHKESLVAGQW--RDMMDYMLQGVAQPSMEEGSGQL 258 Query: 293 LDNFV-----TFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIG---SKRYLDF 344 L+ V I G ET+AN L++ V+ L PEI RLQ E+D +G S + + Sbjct: 259 LEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPY 318 Query: 345 EDLGRLQYLSQVLKESLRLYP--PAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMD 402 +D RL L+ + E LRL P P R + I G +P T ++ + + Sbjct: 319 KDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSS-ISGYDIPEGTVIIPNLQGAHLDE 377 Query: 403 TYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRL 462 T +E P F PDRF P F G R C+G+ A++E+ VV+ +LLQ F L Sbjct: 378 TVWERPHEFWPDRF--LEPGKNSRALAFGCGARVCLGEPLARLELFVVLTRLLQ--AFTL 433 Query: 463 VPGQRF-----GLQEQATLKPLDPVLCTLRPRG 490 +P L + + + P L+PRG Sbjct: 434 LPSGDALPSLQPLPHCSVILKMQPFQVRLQPRG 466 >3TBG-A nrPDB Length = 479 Score = 82.8 bits (203), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 54/189 (28%), Positives = 92/189 (48%), Gaps = 9/189 (4%) Query: 284 EGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLD 343 E + +DE L F AG T++ LA+ ++ + P++ R+Q E+D+VIG R + Sbjct: 265 ESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPE 324 Query: 344 FEDLGRLQYLSQVLKESLR---LYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGR 400 D + Y + V+ E R + P G + + + G R+P T L+ + + + Sbjct: 325 MGDQAHMPYTTAVIHEVQRFGDIVP--LGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLK 382 Query: 401 MDTYFEDPLTFNPDRFGPGAP---KPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQR 457 + +E P F+P+ F KP + PFS G R+C+G+ A+ME+ + LLQ Sbjct: 383 DEAVWEKPFRFHPEHFLDAQGHFVKPE-AFLPFSAGRRACLGEPLARMELFLFFTSLLQH 441 Query: 458 LEFRLVPGQ 466 F + GQ Sbjct: 442 FSFSVPTGQ 450 >1N6B-A nrPDB Length = 473 Score = 81.6 bits (200), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 110/494 (22%), Positives = 195/494 (39%), Gaps = 74/494 (14%) Query: 33 IPGPPRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPES 92 +P P P ++G++ ++ + + +++ YGPV V + K +V++ E+ Sbjct: 11 LPPGPTPFPIIGNIL------QIDAKDISKSLTKFSECYGPVFTVYLGMKPTVVLHGYEA 64 Query: 93 VKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLV------------SECNYERWHKQRRV 140 VK+ L+ GE G+G V + N + W + RR Sbjct: 65 VKEALVD----------------LGEEFAGRGSVPILEKVSKGLGIAFSNAKTWKEMRRF 108 Query: 141 IDLAFSRSSL--VSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAF- 197 + + S+ + E+A LVE E + +P +L +++ F Sbjct: 109 SLMTLRNFGMGKRSIEDRIQEEARCLVE--ELRKTNASPCDPTFILGCAPCNVICSVIFH 166 Query: 198 ---GMETSMLLGAQKPLSQAVKLMLEGITASRNT---LAKFLPGKRKQLREVRESIRFLR 251 + L + L + V+L+ N L + PG K L + + +++ Sbjct: 167 NRFDYKDEEFLKLMESLHENVELLGTPWLQVYNNFPALLDYFPGIHKTLLK---NADYIK 223 Query: 252 QVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDEGLLDNFVT----FFIAGHETS 307 + V+ ++ L P D + L E + E L++ V F AG ET+ Sbjct: 224 NFIMEKVKEHQKLLDVNN--PRDFIDCFLIKMEQENNLEFTLESLVIAVSDLFGAGTETT 281 Query: 308 ANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLR---LY 364 + L ++++ L + PE+ AR+Q E++ VIG R +D R+ Y V+ E R L Sbjct: 282 STTLRYSLLLLLKHPEVAARVQEEIERVIGRHRSPCMQDRSRMPYTDAVIHEIQRFIDLL 341 Query: 365 PPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRF--GPGAPK 422 P + + +P T ++ S + + F +P F+P F G K Sbjct: 342 PTNLP--HAVTRDVRFRNYFIPKGTDIITSLTSVLHDEKAFPNPKVFDPGHFLDESGNFK 399 Query: 423 PRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPV 482 + PFS G R C+G+ A+ME+ + + +L Q F LQ K LD Sbjct: 400 KSDYFMPFSAGKRMCVGEGLARMELFLFLTSIL----------QNFKLQSLVEPKDLD-- 447 Query: 483 LCTLRPRGWQPAPP 496 T G+ PP Sbjct: 448 -ITAVVNGFVSVPP 460 >2HI4-A nrPDB Length = 495 Score = 81.3 bits (199), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 92/440 (20%), Positives = 185/440 (42%), Gaps = 54/440 (12%) Query: 68 AKKYGPVVRVNVFHKTSVIVTSPESVKKFLM--STKYNKDSKMYRALQTVFGERLFGQGL 125 +++YG V+++ + ++++ +++++ L+ + +Y + G+ L Sbjct: 45 SQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSL----T 100 Query: 126 VSECNYERWHKQRRVIDLAFSRSSLVS---------LMETFNEKAEQLVEILEAKADGQT 176 S + W +RR+ A + S+ S L E +++A+ L+ L+ G Sbjct: 101 FSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPG 160 Query: 177 PVSMQDMLTYTAMDILAKAAFGME----TSMLLGAQKPLSQAVKLMLEGITASRNTLAKF 232 + + + +++ FG + +L K + V+ G + ++ Sbjct: 161 HFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRY 220 Query: 233 LPGKRKQ-------------LREVRESIR-FLRQVGRDWVQRRREALKRGEEVPADILTQ 278 LP Q + V+E + F + RD + K+G +++ Q Sbjct: 221 LPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQ 280 Query: 279 ILKAEEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGS 338 E +++ F AG +T +++++M L +PEI ++Q E+D VIG Sbjct: 281 -----------EKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGR 329 Query: 339 KRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRL---LEEETLIDGVRVPGNTPLLFST 395 +R D +L YL + E+ R ++ F + +T ++G +P + + Sbjct: 330 ERRPRLSDRPQLPYLEAFILETFR--HSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQ 387 Query: 396 YVMGRMDTYFEDPLTFNPDRF----GPGAPKP-RFTYFPFSLGHRSCIGQQFAQMEVKVV 450 + + +EDP F P+RF G KP F +G R CIG+ A+ E+ + Sbjct: 388 WQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLF 447 Query: 451 MAKLLQRLEFRLVPGQRFGL 470 +A LLQ+LEF + PG + L Sbjct: 448 LAILLQQLEFSVPPGVKVDL 467 >6IQ5-A nrPDB Length = 463 Score = 78.6 bits (192), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 100/450 (22%), Positives = 179/450 (39%), Gaps = 45/450 (10%) Query: 64 FLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYN-KDSKMYRALQTVFGERLFG 122 F A++YG V ++ + V++ ++ + L+ D + + + V G R Sbjct: 7 FARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPSFASFRVVSGGRSMA 66 Query: 123 QGLVSECNYERWHKQRRVIDLAFS-------RSSLVSLMETFNEKAEQLVEILEAKADGQ 175 G SE W QRR RS V +E E + ++ ADG Sbjct: 67 FGHYSE----HWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALLVRGSADGA 122 Query: 176 TPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLE--GITASRNTLAKFL 233 + + + ++++ FG S P + + E G T +L + Sbjct: 123 F-LDPRPLTVVAVANVMSAVCFGCRYSH----DDPEFRELLSHNEEFGRTVGAGSLVDVM 177 Query: 234 PGKRKQLREVRESIRFLRQVGRDWVQ-------RRREALKRGEEVPADILTQ-ILKAEEG 285 P + VR R Q+ R++ R E+L+ G P D++ IL AE+ Sbjct: 178 PWLQYFPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPGA-APRDMMDAFILSAEKK 236 Query: 286 AQDD----------EGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEV 335 A D E + F A +T + L + ++ +R P++ R+QAE+D+V Sbjct: 237 AAGDSHGGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQV 296 Query: 336 IGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTF-RLLEEETLIDGVRVPGNTPLLFS 394 +G R D L Y+ L E++R T T + G +P +T + + Sbjct: 297 VGRDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVN 356 Query: 395 TYVMGRMDTYFEDPLTFNPDRF--GPGAPKPRFT--YFPFSLGHRSCIGQQFAQMEVKVV 450 + + + +P F+P RF G T FS+G R CIG++ ++M++ + Sbjct: 357 QWSVNHDPVKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLF 416 Query: 451 MAKLLQRLEFRLVPGQ--RFGLQEQATLKP 478 ++ L + +FR P + + T+KP Sbjct: 417 ISILAHQCDFRANPNEPAKMNFSYGLTIKP 446 >4GQS-A nrPDB Length = 477 Score = 78.2 bits (191), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 100/445 (22%), Positives = 187/445 (42%), Gaps = 34/445 (7%) Query: 36 PPRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKK 95 PP P+ LP ++ + + + +K YGPV + + V++ E VK+ Sbjct: 13 PPGPT----PLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKE 68 Query: 96 FLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSL--VSL 153 L+ + + L R FG + N +RW + RR + + S+ Sbjct: 69 ALIDLGEEFSGRGHFPLAER-ANRGFG---IVFSNGKRWKEIRRFSLMTLRNFGMGKRSI 124 Query: 154 METFNEKAEQLVEIL-EAKADGQTPVSMQDMLTYTAM-DILAKAAFGMETSMLLGAQKPL 211 + E+A LVE L + KA P + + I+ + F + L + L Sbjct: 125 EDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKL 184 Query: 212 SQAVKLMLE---GITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRG 268 ++ ++++ I + T+ + PG +L + ++ F+ + V+ +E++ Sbjct: 185 NENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLK---NLAFMESDILEKVKEHQESMDIN 241 Query: 269 EEVPADILTQIL---KAEEGAQDDEGLLDNFVT----FFIAGHETSANHLAFTVMELSRQ 321 P D + L + E+ Q E ++N V AG ET++ L + ++ L + Sbjct: 242 N--PRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKH 299 Query: 322 PEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLR---LYPPAWGTFRLLEEET 378 PE+ A++Q E++ V+G R +D G + Y V+ E R L P + + + Sbjct: 300 PEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLP--HAVTCDV 357 Query: 379 LIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRF-GPGAPKPRFTYF-PFSLGHRS 436 +P T +L S + + F +P F+P F G + YF PFS G R Sbjct: 358 KFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRI 417 Query: 437 CIGQQFAQMEVKVVMAKLLQRLEFR 461 C+G+ A+ME+ + + +LQ + Sbjct: 418 CVGEGLARMELFLFLTFILQNFNLK 442 >3MZS-A nrPDB Length = 486 Score = 76.3 bits (186), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 105/483 (21%), Positives = 197/483 (40%), Gaps = 32/483 (6%) Query: 30 YEHIPGPPRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTS 89 Y IP P +L +L FW+ E G + + ++ +KYGP+ R + + SV + Sbjct: 10 YSEIPSPGDNGWL--NLYHFWR--EKGSQRIHFRHIENFQKYGPIYREKLGNLESVYIIH 65 Query: 90 PESVK---KFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDL-AF 145 PE V KF S D + A + + + G++ + + W K R V++ Sbjct: 66 PEDVAHLFKFEGSYPERYDIPPWLAYHRYYQKPI---GVLFKKS-GTWKKDRVVLNTEVM 121 Query: 146 SRSSLVSLMETFNEKAEQLVEILEAK----ADGQTPVSMQDMLTYTAMDILAKAAFGMET 201 + ++ + + N ++ V +L + G+ +++ L + A + + FG Sbjct: 122 APEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERL 181 Query: 202 SMLLGAQKPLSQ----AVKLMLEGITASRNTLAKFLPGKR-KQLREVRESIRFLRQVGRD 256 ML P +Q AV M N + R K R+ + + Sbjct: 182 GMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKAEK 241 Query: 257 WVQRRREALKRGEEVPA--DILTQILKAEEGAQDDEGLLDNFVTFFIAGHETSANHLAFT 314 + + + L+R E IL +LK+E+ +D + N G T++ L + Sbjct: 242 YTEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLED--VKANITEMLAGGVNTTSMTLQWH 299 Query: 315 VMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQY---LSQVLKESLRLYPPAWGTF 371 + E++R + L+ +EV+ ++R + + LQ L +KE+LRL+P + Sbjct: 300 LYEMARSLNVQEMLR---EEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQ 356 Query: 372 RLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRF-GPGAPKPRFTYFPF 430 R E + ++ +P T + + Y MGR +F P F+P R+ F F Sbjct: 357 RYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGF 416 Query: 431 SLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPVLCTLRPRG 490 G R C+G++ A++E+ + + +L+ + + L P P+ RP Sbjct: 417 GWGVRQCVGRRIAELEMTLFLIHILENFKVEMQHIGDVDTIFNLILTPDKPIFLVFRPFN 476 Query: 491 WQP 493 P Sbjct: 477 QDP 479 >5FSA-A nrPDB Length = 490 Score = 75.5 bits (184), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 89/433 (20%), Positives = 174/433 (40%), Gaps = 53/433 (12%) Query: 69 KKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDS--KMYRALQTVFGERLFGQGLV 126 +KYG V + K + P+ +F+ + K + S + Y+ L T +FG G++ Sbjct: 35 QKYGDVFSFMLLGKIMTVYLGPKG-HEFVFNAKLSDVSAEEAYKHLTT----PVFGTGVI 89 Query: 127 SECNYERWHKQRRVIDLAFSRSSLVSLM-----ETFNEKAEQLVEILEAKADGQTPV--S 179 +C R +Q++ A + S + E N L+ K G V + Sbjct: 90 YDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTHGVANVMKT 149 Query: 180 MQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKF-LPGK-R 237 ++ +TA +++ FG E + + +Q + +G T LP R Sbjct: 150 QPEITIFTA----SRSLFGDEMRRIF--DRSFAQLYSDLDKGFTPINFVFPNLPLPHYWR 203 Query: 238 KQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDEGLLDNFV 297 + + + S +++++ ++R R + ++ +L + D+ + + + Sbjct: 204 RDAAQKKISATYMKEIK---LRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLI 260 Query: 298 TFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVI----GSKRYLDFEDLGRLQYL 353 + G TSA+ A+ ++ L +P + + EV E++ G L +EDL +L + Sbjct: 261 GILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSV 320 Query: 354 SQVLKESLRLYPPAWGTFRLLEEETLIDGVR--VPGNTPLLFSTYVMGRMDTYFEDPLTF 411 + +KE+LR++ P FR + I VP +L S + YF++P F Sbjct: 321 NNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDF 380 Query: 412 NPDRFGPGAPKPRFT----------------------YFPFSLGHRSCIGQQFAQMEVKV 449 +P R+ A K Y PF G CIG+QFA +++ Sbjct: 381 DPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGT 440 Query: 450 VMAKLLQRLEFRL 462 ++ + L + + Sbjct: 441 ILTTFVYNLRWTI 453 >4WMZ-A nrPDB Length = 539 Score = 75.5 bits (184), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 86/431 (19%), Positives = 179/431 (41%), Gaps = 35/431 (8%) Query: 62 DVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLF 121 + F + KKYG + + + + P+ +F+ + K S A +F Sbjct: 78 EFFEECQKKYGDIFSFVLLGRVMTVYLGPKG-HEFVFNAKLADVSA--EAAYAHLTTPVF 134 Query: 122 GQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLV-EILEAKADGQTPVSM 180 G+G++ +C R +Q++ + A ++ + S + E+ + + + + +T ++ Sbjct: 135 GKGVIYDCPNSRLMEQKKFVKGALTKEAFKSYVPLIAEEVYKYFRDSKNFRLNERTTGTI 194 Query: 181 QDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQL 240 M+T M I + + M + + +G T N + LP L Sbjct: 195 DVMVTQPEMTIFTASRSLLGKEMRAKLDTDFAYLYSDLDKGFTPI-NFVFPNLP-----L 248 Query: 241 REVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKA---EEGAQ-DDEGLLDNF 296 R+ + + ++ +E K + D++ ++K ++G + D+ + + Sbjct: 249 EHYRKRDHAQKAISGTYMSLIKERRKNNDIQDRDLIDSLMKNSTYKDGVKMTDQEIANLL 308 Query: 297 VTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVI-GSKRYLDFEDLGRLQYLSQ 355 + + G TSA A+ ++ L+ +P++ L E V+ G K+ L ++ L + L+Q Sbjct: 309 IGVLMGGQHTSAATSAWILLHLAERPDVQQELYEEQMRVLDGGKKELTYDLLQEMPLLNQ 368 Query: 356 VLKESLRLYPPAWGTFRLLEEETLIDGVR--VPGNTPLLFSTYVMGRMDTYFEDPLTFNP 413 +KE+LR++ P FR + ++ + +P +L S D YF + FN Sbjct: 369 TIKETLRMHHPLHSLFRKVMKDMHVPNTSYVIPAGYHVLVSPGYTHLRDEYFPNAHQFNI 428 Query: 414 DR----------------FGPGAPKPRFT--YFPFSLGHRSCIGQQFAQMEVKVVMAKLL 455 R +G GA + Y PF G CIG+ FA ++ V+M+ + Sbjct: 429 HRWNNDSASSYSVGEEVDYGFGAISKGVSSPYLPFGGGRHRCIGEHFAYCQLGVLMSIFI 488 Query: 456 QRLEFRLVPGQ 466 + L++ G+ Sbjct: 489 RTLKWHYPEGK 499 >5JLC-A nrPDB Length = 515 Score = 73.6 bits (179), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 85/427 (19%), Positives = 179/427 (41%), Gaps = 36/427 (8%) Query: 62 DVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLF 121 + F D KKYG + + + + P+ +F+ + K S A + +F Sbjct: 60 EFFEDCQKKYGDIFSFMLLGRIMTVYLGPKG-HEFIFNAKLADVSA--EAAYSHLTTPVF 116 Query: 122 GQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQ 181 G+G++ +C R +Q++ + A ++ + V + E+ + + + + Sbjct: 117 GKGVIYDCPNHRLMEQKKFVKGALTKEAFVRYVPLIAEEIYKYFRNSKNFKINENNSGIV 176 Query: 182 D-MLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQL 240 D M++ M I + + M + + +G T N + LP L Sbjct: 177 DVMVSQPEMTIFTASRSLLGKEMRDKLDTDFAYLYSDLDKGFTPI-NFVFPNLP-----L 230 Query: 241 REVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKA---EEGAQ-DDEGLLDNF 296 R+ + + ++ +E ++ + D++ +++K ++G + D+ + + Sbjct: 231 EHYRKRDHAQQAISGTYMSLIKERREKNDIQNRDLIDELMKNSTYKDGTKMTDQEIANLL 290 Query: 297 VTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSK-RYLDFEDLGRLQYLSQ 355 + + G TSA A+ ++ L+ +P++ L E V+ + + L ++DL + L+Q Sbjct: 291 IGVLMGGQHTSAATSAWCLLHLAERPDVQEELYQEQMRVLNNDTKELTYDDLQNMPLLNQ 350 Query: 356 VLKESLRLYPPAWGTFRLLEEETLIDGVR--VPGNTPLLFSTYVMGRMDTYFEDPLTFNP 413 ++KE+LRL+ P FR + + I VP + +L S + +F P FN Sbjct: 351 MIKETLRLHHPLHSLFRKVMRDVAIPNTSYVVPRDYHVLVSPGYTHLQEEFFPKPNEFNI 410 Query: 414 DR-----------------FGPGAPKPRFT--YFPFSLGHRSCIGQQFAQMEVKVVMAKL 454 R +G GA + Y PF G CIG+ FA ++ V+M+ Sbjct: 411 HRWDGDAASSSAAGGDEVDYGFGAISKGVSSPYLPFGGGRHRCIGELFAYCQLGVLMSIF 470 Query: 455 LQRLEFR 461 ++ +++R Sbjct: 471 IRTMKWR 477 >3E6I-A nrPDB Length = 476 Score = 72.8 bits (177), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 101/423 (23%), Positives = 178/423 (42%), Gaps = 43/423 (10%) Query: 64 FLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQ 123 F A+++GPV + V + V++ ++VK+ L+ Y + L R + Sbjct: 36 FTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLD--YKDEFSGRGDLPAFHAHR--DR 91 Query: 124 GLVSECNYERWHKQRRVIDLAFSRSSL--VSLMETFNE-----KAEQLVEILEAKADGQ- 175 G++ N W RR FS ++L + + NE +A L+E L K GQ Sbjct: 92 GIIFN-NGPTWKDIRR-----FSLTTLRNYGMGKQGNESRIQREAHFLLEALR-KTQGQP 144 Query: 176 -TPVSMQDMLTYTAM-DILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFL 233 P + + DIL + F L ++ L+ N FL Sbjct: 145 FDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFL 204 Query: 234 PGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADI----LTQILKAEEGAQ-- 287 R+V +++ +++ + V+ ++L P D+ L ++ K + A+ Sbjct: 205 HYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLD--PNCPRDLTDCLLVEMEKEKHSAERL 262 Query: 288 -DDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFED 346 +G+ F AG ET++ L + ++ L + PEI +L E+D VIG R +D Sbjct: 263 YTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKD 322 Query: 347 LGRLQYLSQVLKESLR---LYP---PAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGR 400 + Y+ V+ E R L P P T +T+ G +P T ++ + + Sbjct: 323 RQEMPYMDAVVHEIQRFITLVPSNLPHEAT-----RDTIFRGYLIPKGTVVVPTLDSVLY 377 Query: 401 MDTYFEDPLTFNPDRFGPGAPKPRFT-YF-PFSLGHRSCIGQQFAQMEVKVVMAKLLQRL 458 + F DP F P+ F K +++ YF PFS G R C G+ A+ME+ +++ +LQ Sbjct: 378 DNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHF 437 Query: 459 EFR 461 + Sbjct: 438 NLK 440 >3N9Z-A nrPDB Length = 487 Score = 71.2 bits (173), Expect = 9e-13, Method: Compositional matrix adjust. Identities = 104/481 (21%), Positives = 189/481 (39%), Gaps = 37/481 (7%) Query: 30 YEHIPGPPRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTS 89 + IP P +L +L FW+ E G + + +KYGP+ R + + SV V Sbjct: 8 FNEIPSPGDNGWL--NLYHFWR--ETGTHKVHLHHVQNFQKYGPIYREKLGNVESVYVID 63 Query: 90 PESVKKFLMSTKYNKDSKM---YRALQTVFGERLFGQGLVSECNYERWHKQRRVIDL-AF 145 PE V S N + + + A + +R G L W K R ++ Sbjct: 64 PEDVALLFKSEGPNPERFLIPPWVAYHQYY-QRPIGVLLKKSA---AWKKDRVALNQEVM 119 Query: 146 SRSSLVSLMETFNEKAEQLVEILEAK----ADGQTPVSMQDMLTYTAMDILAKAAFGMET 201 + + + + + + V +L + G + D L A + + FG Sbjct: 120 APEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQ 179 Query: 202 SMLLGAQKPLSQ----AVKLMLEGITASRNTLAK-FLPGKRKQLREVRESIRFLRQVGRD 256 ML P +Q A+ M N F + K ++ + + Sbjct: 180 GMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADI 239 Query: 257 WVQRRREALKRGEEVPAD---ILTQILKAEEGAQDDEGLLDNFVTFFIAGHETSANHLAF 313 + Q L++ V D IL ++L + + +D + N G +T++ L + Sbjct: 240 YTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFED--IKANVTEMLAGGVDTTSMTLQW 297 Query: 314 TVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQY---LSQVLKESLRLYPPAWGT 370 + E++R ++ L+AEV + ++ + LQ L +KE+LRL+P + Sbjct: 298 HLYEMARNLKVQDMLRAEV---LAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTL 354 Query: 371 FRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYF-- 428 R L + ++ +P T + + Y +GR T+F DP F+P R+ + TYF Sbjct: 355 QRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRW--LSKDKNITYFRN 412 Query: 429 -PFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPVLCTLR 487 F G R C+G++ A++E+ + + +L+ + G L P P+ T Sbjct: 413 LGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKPISFTFW 472 Query: 488 P 488 P Sbjct: 473 P 473 >4GGV-A nrPDB Length = 418 Score = 67.8 bits (164), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 83/345 (24%), Positives = 145/345 (42%), Gaps = 57/345 (16%) Query: 123 QGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQD 182 +G +S+ + R K R+++ AF+ LV+ MET A+ E+L+A DG+ + + Sbjct: 92 EGDMSQMDPPRHRKYRQLVSRAFT-PRLVADMET--RVADITRELLDA-VDGKPEIEIAA 147 Query: 183 MLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLRE 242 L Y I+ G+ G + + ++EG + FL + ++ Sbjct: 148 DLAYPLPVIVIAELLGVPA----GDRDLFKKWADDIIEGFSG-----FSFLDTSGQGEQD 198 Query: 243 VRESIRFLRQV----GRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDEGLLDNFVT 298 VR++ LR + +RRR + D+LT +++AE D E L DN + Sbjct: 199 VRDATERLRPLLDYMAGHVTERRRTPRE-------DLLTHLVQAE---VDGERLTDNEIV 248 Query: 299 -----FFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYL 353 + GH T+ L TV+ L PE+ A+++A+ V G+ Sbjct: 249 NVANILLVTGHITTTMTLGNTVLCLDADPEVAAKVRADRSLVPGA--------------- 293 Query: 354 SQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNP 413 ++E+LR+ P+ R E + G +P + ++ R F DP ++P Sbjct: 294 ---IEEALRVLSPSAALARGTSREVEVAGTVIPKDQIVMLWLGAGNRDPRQFTDPEVYDP 350 Query: 414 DRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRL 458 R P P +F F G C+G A++E +V + L R Sbjct: 351 TR----DPNP---HFGFGRGIHFCLGAPLARLEGRVALNALFDRF 388 >6DWN-A nrPDB Length = 491 Score = 67.8 bits (164), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 93/431 (21%), Positives = 179/431 (41%), Gaps = 35/431 (8%) Query: 68 AKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGL-V 126 +++YG V+++ + V+++ +++++ L+ + D K L T F GQ + Sbjct: 40 SQQYGDVLQIRIGSTPVVVLSGLDTIRQALV--RQGDDFKGRPDLYT-FTLISNGQSMSF 96 Query: 127 SECNYERWHKQRRVIDLAFSRSSLVS---------LMETFNEKAEQLVEILEAKADGQTP 177 S + W +RR+ S+ S L E +++AE L+ L+ G Sbjct: 97 SPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGH 156 Query: 178 VSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKR 237 + + + +++ FG Q+ LS G A F+P R Sbjct: 157 FNPYRYVVVSVTNVICAICFGRRYDH--NHQELLSLVNLNNNFGEVVGSGNPADFIPILR 214 Query: 238 KQLREVRESIRFLRQVGRDWVQRR-REALKRGEEVPADILTQIL-------KAEEGAQ-- 287 + + L + ++Q+ +E K E+ +T L + +E A Sbjct: 215 YLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQ 274 Query: 288 -DDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFED 346 DE +++ + F AG +T +++++M L P + ++Q E+D VIG R D Sbjct: 275 LSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSD 334 Query: 347 LGRLQYLSQVLKESLRLYPPAWGTFRL---LEEETLIDGVRVPGNTPLLFSTYVMGRMDT 403 L Y+ + E+ R ++ F + +T + G +P + + + + Sbjct: 335 RSHLPYMEAFILETFR--HSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQK 392 Query: 404 YFEDPLTFNPDRF--GPGAPKPRFT--YFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLE 459 + +P F P+RF GA + F +G R CIG+ A+ EV + +A LLQR+E Sbjct: 393 LWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVE 452 Query: 460 FRLVPGQRFGL 470 F + G + + Sbjct: 453 FSVPLGVKVDM 463 >4UBS-A nrPDB Length = 393 Score = 65.1 bits (157), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 68/260 (26%), Positives = 102/260 (39%), Gaps = 43/260 (16%) Query: 245 ESIRFLRQVGRDWVQRRREALK--------RGEEVPADILTQILKAEE---GAQDDEGLL 293 +S R LR G VQ R L R + P D L L E+ G D L+ Sbjct: 164 QSRRLLRGPGIAEVQDARAQLDDYLYALIDRKRKEPGDGLLDDLIQEQLNRGTVDRAELV 223 Query: 294 DNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYL 353 IAGHET+AN ++ L R PE +A L+AE + Sbjct: 224 SLATLLLIAGHETTANMISLGTFTLLRHPEQLAELRAEPG------------------LM 265 Query: 354 SQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNP 413 ++E LR A G R+ E+ + G + + ++F+T V+ R F +P + Sbjct: 266 PAAVEELLRFLSIADGLLRVATEDIEVAGTTIRADEGVVFATSVINRDAAGFAEPDALDW 325 Query: 414 DRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGL-QE 472 R + F G C+GQ A+ E+++ + L +RL PG R + Sbjct: 326 HRSA-------RHHVAFGFGIHQCLGQNLARAEMEIALGTLFERL-----PGLRLAAPAD 373 Query: 473 QATLKPLDPVLCTLR-PRGW 491 + KP D + L P W Sbjct: 374 EIPFKPGDTIQGMLELPVTW 393 >4ZGX-A nrPDB Length = 489 Score = 64.3 bits (155), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 90/392 (22%), Positives = 154/392 (39%), Gaps = 29/392 (7%) Query: 69 KKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSE 128 ++ GP+ R N+ V V PE V+K L +M + + + V Sbjct: 50 QELGPIFRYNLGGPRMVCVMLPEDVEK-LQQVDSLHPCRMILEPWVAYRQHRGHKCGVFL 108 Query: 129 CNYERWHKQR-RVIDLAFSRSSLVSLMETFNEKAEQLVEILEAK----ADGQTPVSMQDM 183 N W R R+ S ++ + + A + L+ K A G + +Q Sbjct: 109 LNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPS 168 Query: 184 LTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLM--LEGITASRNTLAKFLPGKR---- 237 + + ++ A FG ++ P S ++ + LE + S L F+P Sbjct: 169 IFHYTIEASNLALFGERLGLV--GHSPSSASLNFLHALEVMFKSTVQLM-FMPRSLSRWI 225 Query: 238 --KQLREVRESIRFLRQVGRDWVQR--RREALKRGEEVPADILTQILKAEEGAQDDEGLL 293 K +E E+ + Q G + +Q+ + A R + + +LKAE E + Sbjct: 226 SPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELSL---EAIK 282 Query: 294 DNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYL 353 N + +T+A L T+ EL+R P++ L+ E S + L L Sbjct: 283 ANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLL 342 Query: 354 SQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNP 413 LKE+LRLYP R++ + ++ +P T + Y +GR F P +NP Sbjct: 343 RAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNP 402 Query: 414 DRF----GPGAPKPRFTYFPFSLGHRSCIGQQ 441 R+ G G F + PF G R C+G++ Sbjct: 403 QRWLDIRGSGR---NFHHVPFGFGMRQCLGRR 431 >5Z9I-A nrPDB Length = 398 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 58/204 (28%), Positives = 93/204 (45%), Gaps = 30/204 (14%) Query: 257 WVQRRREALKRGEEVPADILTQILKAE-EGAQDDEGLLDNFVT-FFIAGHETSANHLAFT 314 W +R E+ KR E D+++Q++ AE +G + ++ + N + GH T+A +A T Sbjct: 193 WHERAAESRKRPRE---DLISQLVHAEVDGQKLNDSQISNIANRLLVNGHLTTAMLIANT 249 Query: 315 VMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLL 374 ++ L + AR++A+ R L + +L+ES+R P G R Sbjct: 250 MLCLDAFSDQDARVRAD--------RSL----------VPALLEESMRYMSPICGVGRAT 291 Query: 375 EEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGH 434 E + G +P + LL T R + FE P F+ R P A + F G Sbjct: 292 NSEVEVAGTVIPKDQLLLVWTGAANRDERQFEKPDVFDAGR-SPNA------HLGFGRGI 344 Query: 435 RSCIGQQFAQMEVKVVMAKLLQRL 458 C+G+Q A+ME K + LL RL Sbjct: 345 HFCLGRQLARMESKAAVEILLDRL 368 >3L4D-A nrPDB Length = 453 Score = 63.2 bits (152), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 87/431 (20%), Positives = 177/431 (41%), Gaps = 32/431 (7%) Query: 42 LLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVF-HKTSVIVTSPESVKKFLMST 100 +GH+ F KD +G L KKYG + +N+ ++ +V+ + K F Sbjct: 14 FVGHIIQF-GKDPLG------FMLKAKKKYGGIFTMNICGNRITVVGDVHQHSKFFTPRN 66 Query: 101 KYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEK 160 + ++Y + VFGE G+ Y R +Q + + + + + + Sbjct: 67 EILSPREVYSFMVPVFGE-----GVAYAAPYPRMREQLNFLAEELTVAKFQNFAPSIQHE 121 Query: 161 AEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLE 220 + ++ K +G+ +++ D + ++ + FG + L A++ +Q + M Sbjct: 122 VRKFMKANWNKDEGE--INILDDCSAMIINTACQCLFGEDLRKRLDARQ-FAQLLAKMES 178 Query: 221 GITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQIL 280 + + L L Q R++ L+ + + + R + + + +D+L +L Sbjct: 179 CLIPAAVFLPWILKLPLPQSYRCRDARAELQDILSEIIIAREKEEAQKDTNTSDLLAGLL 238 Query: 281 KA--EEGAQ-DDEGLLDNFVTFFIAGHETSANHLAFTVMEL--SRQPEIVARLQAEVDEV 335 A +G + + V AG TS ++++ L R +A+L E+DE Sbjct: 239 GAVYRDGTRMSQHEVCGMIVAAMFAGQHTSTITTTWSLLHLMDPRNKRHLAKLHQEIDEF 298 Query: 336 IGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFST 395 Y + + + + Q +ES+R PP R + + + VP + S Sbjct: 299 PAQLNYDNV--MEEMPFAEQCARESIRRDPPLVMLMRKVLKPVQVGKYVVPEGDIIACSP 356 Query: 396 YVMGRMDTYFEDPLTFNPDR---FGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMA 452 + + + F +P +NP+R GA + F G CIG++F ++VK V+A Sbjct: 357 LLSHQDEEAFPNPREWNPERNMKLVDGA------FCGFGAGVHKCIGEKFGLLQVKTVLA 410 Query: 453 KLLQRLEFRLV 463 +L+ +F L+ Sbjct: 411 TVLRDYDFELL 421 >5HDI-A nrPDB Length = 404 Score = 63.2 bits (152), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 45/162 (27%), Positives = 70/162 (43%), Gaps = 24/162 (14%) Query: 296 FVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQ 355 VT F AG E++A L V L+ +P+I +++A + L Sbjct: 238 MVTLFAAGGESTAALLGSAVWILATRPDIQQQVRANP------------------ELLGA 279 Query: 356 VLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDR 415 ++E+LR PP G +R + T +DG +P ++ LL R FE P F DR Sbjct: 280 FIEETLRYEPPFRGHYRHVRNATTLDGTELPADSHLLLLWGAANRDPAQFEAPGEFRLDR 339 Query: 416 FGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQR 457 G + F G C+G A++E ++V+ LL R Sbjct: 340 AGGKG------HISFGKGAHFCVGAALARLEARIVLRLLLDR 375 >3EJB-B nrPDB Length = 404 Score = 62.8 bits (151), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 50/194 (25%), Positives = 86/194 (44%), Gaps = 26/194 (13%) Query: 266 KRGEEVPADILTQILKAEEGAQ-DDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEI 324 KR D+++ +LK E + +E + IAGHET+ N ++ +V+ L + PE Sbjct: 197 KRKRHPQQDMISMLLKGREKDKLTEEEAASTCILLAIAGHETTVNLISNSVLCLLQHPEQ 256 Query: 325 VARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVR 384 + +L+ D +IG+ ++E LR P T R+ E+ I GV Sbjct: 257 LLKLRENPD-LIGT-----------------AVEECLRYESPTQMTARVASEDIDICGVT 298 Query: 385 VPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQ 444 + + R + F +P F+ R +P P + F GH C+G A+ Sbjct: 299 IRQGEQVYLLLGAANRDPSIFTNPDVFDITR----SPNPHLS---FGHGHHVCLGSSLAR 351 Query: 445 MEVKVVMAKLLQRL 458 +E ++ + LLQR+ Sbjct: 352 LEAQIAINTLLQRM 365 >2Y5N-A nrPDB Length = 417 Score = 62.0 bits (149), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 109/453 (24%), Positives = 174/453 (38%), Gaps = 89/453 (19%) Query: 37 PRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYG------PVVRVNV-FHKTSVIVTS 89 PR S + P + ++V G L A +YG PV RV + + + +VT Sbjct: 16 PRGSHMTSAEPRAYPFNDVHG-------LTLAGRYGELQETEPVSRVRPPYGEEAWLVTR 68 Query: 90 PESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSS 149 E V+ L ++ + M R E + G GL+S E + RR++ AF+ Sbjct: 69 YEDVRAVLGDGRFVRGPSMTRDEPRTRPEMVKG-GLLSMDPPEH-SRLRRLVVKAFTARR 126 Query: 150 LVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQK 209 SL E A +LV+ + A T D++A + Q Sbjct: 127 AESLRPRAREIAHELVDQMAA--------------TGQPADLVA----------MFARQL 162 Query: 210 PLSQAVKLMLEGITASRNTL-----AKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREA 264 P+ +L+ G+ ++ + FL E++E+ D + RRR+ Sbjct: 163 PVRVICELL--GVPSADHDRFTRWSGAFLSTAEVTAEEMQEAAEQAYAYMGDLIDRRRKE 220 Query: 265 LKRGEEVPADILTQILKAEEGAQD---DEGLLDNFVTFFIAGHETSANHLAFTVMELSRQ 321 P D L L QD ++ LLD + +AG+E++ +A V L + Sbjct: 221 -------PTDDLVSALVQARDQQDSLSEQELLDLAIGLLVAGYESTTTQIADFVYLLMTR 273 Query: 322 PEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTF--RLLEEETL 379 PE+ +L L R + + ++E R P GT R E+ Sbjct: 274 PELRRQL------------------LDRPELIPSAVEELTRWVPLGVGTAFPRYAVEDVT 315 Query: 380 IDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIG 439 + GV + P+L ST R F D + DR P + F G C+G Sbjct: 316 LRGVTIRAGEPVLASTGAANRDQAQFPDADRIDVDR----TPN---QHLGFGHGVHHCLG 368 Query: 440 QQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQE 472 A++E++V + LLQRL PG R G+ E Sbjct: 369 APLARVELQVALEVLLQRL-----PGIRLGIPE 396 >6GMF-A nrPDB Length = 397 Score = 62.0 bits (149), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 53/187 (28%), Positives = 85/187 (45%), Gaps = 27/187 (14%) Query: 274 DILTQILKAE-EGAQDDEGLLDNFV-TFFIAGHETSANHLAFTVMELSRQPEIVARLQAE 331 D+++Q+L AE +G + G + +F T IAG+ET+ + + ++ L+ PE +A QA+ Sbjct: 203 DLISQLLAAEVDGEKLTAGEVLSFANTLLIAGNETTTSLIGNALVALTDHPEQLAAAQAD 262 Query: 332 VDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPL 391 L + V++E LR PA FR + I R+P + + Sbjct: 263 ------------------LSLVPAVVEEVLRYESPAQCIFRQTMTDVEIGDERIPARSVV 304 Query: 392 LFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVM 451 L R ++ F DP F+ R G + F L CIG A++E KV++ Sbjct: 305 LPLLASANRDESRFPDPDRFDIHRDTKG-------HLAFGLDIHFCIGAPLARLEAKVML 357 Query: 452 AKLLQRL 458 LL RL Sbjct: 358 EVLLARL 364 >2WX2-A nrPDB Length = 473 Score = 61.2 bits (147), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 70/356 (19%), Positives = 150/356 (42%), Gaps = 28/356 (7%) Query: 120 LFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVS 179 +FG+G+ Y R +Q + + + + + + + + E + + ++ Sbjct: 95 VFGEGVAYAAPYPRMREQLNFLAEELTIAKFQNFVPAIQHEVRKF--MAENWKEDEGVIN 152 Query: 180 MQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPG---- 235 + + ++ + FG + L A+ +Q +L + +S A F+P Sbjct: 153 LLEDCGAMIINTACQCLFGEDLRKRLNARH-FAQ----LLSKMESSLIPAAVFMPWLLRL 207 Query: 236 ---KRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKA--EEGAQDD- 289 + + RE R ++ + +G V R +E + +D+L +LKA +G + Sbjct: 208 PLPQSARCREARAELQ--KILGEIIVAREKEEASKDNNT-SDLLGGLLKAVYRDGTRMSL 264 Query: 290 EGLLDNFVTFFIAGHETSANHLAFTVMEL--SRQPEIVARLQAEVDEVIGSKRYLDFEDL 347 + V AG TS +++++ L + + + +L E+DE Y + D Sbjct: 265 HEVCGMIVAAMFAGQHTSTITTSWSMLHLMHPKNKKWLDKLHKEIDEFPAQLNYDNVMD- 323 Query: 348 GRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFED 407 + + + ++ES+R PP R+++ E + VP + S + + F + Sbjct: 324 -EMPFAERCVRESIRRDPPLLMVMRMVKAEVKVGSYVVPKGDIIACSPLLSHHDEEAFPN 382 Query: 408 PLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLV 463 P ++P+R K + F G CIGQ+FA ++VK ++A + +F+L+ Sbjct: 383 PRLWDPER----DEKVDGAFIGFGAGVHKCIGQKFALLQVKTILATAFREYDFQLL 434 >2Z36-A nrPDB Length = 413 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 56/198 (28%), Positives = 86/198 (43%), Gaps = 29/198 (14%) Query: 265 LKRGEEVPADIL--TQILKA-EEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQ 321 + R E P D L QI + +EG D GL+ AGHET+AN ++ V+ L Sbjct: 205 ITRKESEPGDDLFSRQIARQRQEGTLDHAGLVSLAFLLLTAGHETTANMISLGVVGLLSH 264 Query: 322 PEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWG-TFRLLEEETLI 380 PE + ++A + GR ++E LR + A G T RL E+ I Sbjct: 265 PEQLTVVKA---------------NPGR---TPMAVEELLRYFTIADGVTSRLATEDVEI 306 Query: 381 DGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQ 440 GV + ++ S F+DP + +R GA + F G C+GQ Sbjct: 307 GGVSIKAGEGVIVSMLSANWDPAVFKDPAVLDVER---GARH----HLAFGFGPHQCLGQ 359 Query: 441 QFAQMEVKVVMAKLLQRL 458 A+ME+++V L +R+ Sbjct: 360 NLARMELQIVFDTLFRRI 377 >3MGX-A nrPDB Length = 415 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 51/190 (26%), Positives = 80/190 (42%), Gaps = 32/190 (16%) Query: 272 PADILTQILKAEEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQ-- 329 P D L L ++ D+ LL N I G+ET+ + + V L+ P ++ L+ Sbjct: 225 PGDDLVSTLVTDDDLTIDDVLL-NCDNVLIGGNETTRHAITGAVHALATVPGLLTALRDG 283 Query: 330 -AEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGN 388 A+VD V+ +E LR PA R+ + I+G +P Sbjct: 284 SADVDTVV---------------------EEVLRWTSPAMHVLRVTTADVTINGRDLPSG 322 Query: 389 TPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVK 448 TP++ R F+DP TF P R KP + F G C+G A++E+ Sbjct: 323 TPVVAWLPAANRDPAEFDDPDTFLPGR------KPN-RHITFGHGMHHCLGSALARIELS 375 Query: 449 VVMAKLLQRL 458 VV+ L +R+ Sbjct: 376 VVLRVLAERV 385 >6M7X-A nrPDB Length = 484 Score = 58.2 bits (139), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 52/210 (24%), Positives = 88/210 (41%), Gaps = 12/210 (5%) Query: 238 KQLREVRESIRFLRQVGRDWVQRRRE--ALKRGEEVPADILTQILKAEEGAQDDEGLLDN 295 K +E E+ + Q G + +Q+ + A R ++ + + +L AE + + N Sbjct: 228 KVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAE---LSPDAIKAN 284 Query: 296 FVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQ 355 + +T+ L T+ EL+R P + L+ E S + L L Sbjct: 285 SMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRA 344 Query: 356 VLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDR 415 LKE+LRLYP R+ + ++ +P T + Y +GR F P +NP R Sbjct: 345 ALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQR 404 Query: 416 F----GPGAPKPRFTYFPFSLGHRSCIGQQ 441 + G G F + PF G R C+G++ Sbjct: 405 WLDIRGSGR---NFYHVPFGFGMRQCLGRR 431 >3WVS-A nrPDB Length = 401 Score = 58.2 bits (139), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 55/200 (27%), Positives = 81/200 (40%), Gaps = 30/200 (15%) Query: 272 PADILTQILKAEEGAQD---DEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARL 328 PAD L + QD ++ LLD+ + IAGHET+A+ + V L QP+ Sbjct: 208 PADDLISGMIEARDVQDKLTEQELLDHCIGLLIAGHETTASQIPSFVYALLDQPQ----- 262 Query: 329 QAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTF--RLLEEETLIDGVRVP 386 KR LD +L + ++E R P G+ R E+ + G V Sbjct: 263 --------HWKRLLDDPEL-----IPSAVEELFRFVPLGSGSAAPRYAREDIEVGGTLVR 309 Query: 387 GNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQME 446 P+L + R FEDP DR P + F G C+G A++E Sbjct: 310 AGEPVLVALGAANRDGLRFEDPEEIKLDR-------PSNHHIGFGHGIHHCLGAPLARLE 362 Query: 447 VKVVMAKLLQRLEFRLVPGQ 466 ++ + LL+RL V G Sbjct: 363 LQEALRALLERLPTLKVAGD 382 >5L94-A nrPDB Length = 410 Score = 58.2 bits (139), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 50/186 (26%), Positives = 84/186 (45%), Gaps = 27/186 (14%) Query: 274 DILTQILKA-EEGAQ-DDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAE 331 DI++ +L+A EEG Q DE ++ + IAG+ET+ N ++ T+ L RL+ E Sbjct: 212 DIISVLLQAKEEGKQLTDEEIVGFSILLLIAGNETTTNLISNTIYCLMEDKASFERLKRE 271 Query: 332 VDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPL 391 + L ++E LR P R+++E+ + G ++ + Sbjct: 272 K------------------ELLPSGIEEVLRYRSPVQALHRIVKEDVTLAGKKLKAGEHV 313 Query: 392 LFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVM 451 + R YFEDP F DR KP + F G C+G A++E K+++ Sbjct: 314 VPWMGSAHRDAEYFEDPEVFKIDR------KPN-VHMAFGRGIHFCLGAPLARIEAKIML 366 Query: 452 AKLLQR 457 A+L+ R Sbjct: 367 AELIDR 372 >6B11-A nrPDB Length = 440 Score = 58.2 bits (139), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 55/212 (25%), Positives = 85/212 (40%), Gaps = 41/212 (19%) Query: 255 RDWVQRRREALKRGEEVPADIL-TQILKAEEGAQDDEGLLDNFVTFFIAGHETSANHLAF 313 RD++ R K G E +L + + +A G +LDN V AGHET+A+ + Sbjct: 232 RDYLDRLISG-KTGRESGDGMLGSMVAQARGGGLSHADVLDNAVLLLAAGHETTASMVTM 290 Query: 314 TVMELSRQP----EIVAR---LQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPP 366 +V+ L + P E+ L VDE++ RYL D Sbjct: 291 SVLVLLQHPTAWRELTVNPGLLPGAVDELL---RYLSIAD-------------------- 327 Query: 367 AWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFT 426 G R + IDG + L+F R + F +P F+ R Sbjct: 328 --GLRRSATADIEIDGHTIRAGDGLVFLLAAANRDEAVFSEPEAFDIHRSA-------RR 378 Query: 427 YFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRL 458 + F G C+GQ A+ME++V + +L+RL Sbjct: 379 HVAFGYGPHQCLGQNLARMELEVALGAVLERL 410 >5FOI-A nrPDB Length = 408 Score = 57.8 bits (138), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 50/200 (25%), Positives = 79/200 (39%), Gaps = 33/200 (16%) Query: 275 ILTQILKAEEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDE 334 + ++LK E Q+ L++N V AGHETSAN + +V+ L R PE A L+ + Sbjct: 223 VTERLLKGEITHQE---LVNNAVLLLAAGHETSANQVTLSVLTLLRHPETAAELREQP-- 277 Query: 335 VIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFS 394 + + + E LR + A G R + ++ + L+ Sbjct: 278 ----------------ELMPNAVDELLRYHSIADGLRRAATADIVLGDHTIRAGDGLIIL 321 Query: 395 TYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKL 454 F TF+ R P + F G C+GQ A++E++V + KL Sbjct: 322 LSSANHDGNTFGAEATFDIHR-------PARHHVAFGYGPHQCLGQNLARLEMEVTLGKL 374 Query: 455 LQRLEFRLVPGQRFGLQEQA 474 FR VP R + A Sbjct: 375 -----FRRVPALRLAQEPDA 389 >3ABB-A nrPDB Length = 408 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 55/221 (24%), Positives = 91/221 (41%), Gaps = 40/221 (18%) Query: 265 LKRGEEVPADILTQILKA---EEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQ 321 + R + P D L L A EEG D + ++ + +AGHET+ N +A + L + Sbjct: 203 VGRKQAEPEDGLLDELIARQLEEGDLDHDEVVMIALVLLVAGHETTVNAIALGALTLIQH 262 Query: 322 PEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLID 381 PE + L D G +S V++E LR + R+ +E+ + Sbjct: 263 PEQIDVL---------------LRDPG---AVSGVVEELLRFTSVSDHIVRMAKEDIEVG 304 Query: 382 GVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQ 441 G + +L S +M R +E+P F+ A + + F G C+GQ Sbjct: 305 GATIKAGDAVLVSITLMNRDAKAYENPDIFD-------ARRNARHHVGFGHGIHQCLGQN 357 Query: 442 FAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPV 482 A+ E+++ + L R +PG R + PLD V Sbjct: 358 LARAELEIALGGLFAR-----IPGLRLAV-------PLDEV 386 >2ZBZ-A nrPDB Length = 412 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 51/196 (26%), Positives = 85/196 (43%), Gaps = 30/196 (15%) Query: 284 EGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLD 343 G D E L+ + IAGHET+A+ + +V+ L PE A L+A+ V G+ L Sbjct: 226 NGEIDREELISTAMLLLIAGHETTASMTSLSVITLLDHPEQYAALRADRSLVPGAVEEL- 284 Query: 344 FEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDT 403 L+YL+ + A G R+ + ++G + ++ + R T Sbjct: 285 ------LRYLA--------IADIAGG--RVATADIEVEGQLIRAGEGVIVVNSIANRDGT 328 Query: 404 YFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLV 463 +EDP + R + F G C+GQ A++E++V++ L+ R V Sbjct: 329 VYEDPDALDIHRSA-------RHHLAFGFGVHQCLGQNLARLELEVILNALMDR-----V 376 Query: 464 PGQRFGLQ-EQATLKP 478 P R + EQ L+P Sbjct: 377 PTLRLAVPVEQLVLRP 392 >3P3Z-A nrPDB Length = 416 Score = 56.6 bits (135), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 53/205 (25%), Positives = 89/205 (43%), Gaps = 30/205 (14%) Query: 266 KRGEEVPADILTQILKA-EEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEI 324 KR E D+ + I++A +G DD L T +AG+ET+ + LA + + ++ P+ Sbjct: 216 KRKVEPGDDLTSDIVRAFHDGVLDDYELRTLVATVLVAGYETTNHQLALAMYDFAQHPDQ 275 Query: 325 VARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYP--PAWGTFRLLEEETLIDG 382 +++ + Q ++E LR P P T R+ E+ ++G Sbjct: 276 WMKIKENP------------------ELAPQAVEEVLRWSPTLPVTAT-RVAAEDFEVNG 316 Query: 383 VRVPGNTPLLFSTYVMGRMDTYFEDPLTF-NPDRFGPGAPKPRFTYFPFSLGHRSCIGQQ 441 VR+P TP+ +V R DP F + DRF K F G C+G Sbjct: 317 VRIPTGTPVFMCAHVAHR------DPRVFADADRFDITV-KREAPSIAFGGGPHFCLGTA 369 Query: 442 FAQMEVKVVMAKLLQRLEFRLVPGQ 466 A++E+ +A L RL+ + G+ Sbjct: 370 LARLELTEAVAALATRLDPPQIAGE 394 >2X2N-A nrPDB Length = 475 Score = 55.8 bits (133), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 76/397 (19%), Positives = 159/397 (40%), Gaps = 22/397 (5%) Query: 74 VVRVNVFHKTSVIVTSP-ESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYE 132 + +N+ K IV P E + FL + ++Y + VFGE G+ Y Sbjct: 53 IFTINIVGKRVTIVGDPHEHSRFFLPRNEVLSPREVYSFMVPVFGE-----GVAYAAPYP 107 Query: 133 RWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDIL 192 R +Q + + + + + + + + K +G+ +++ + + ++ Sbjct: 108 RMREQLNFLAEELTIAKFQNFVPAIQHEVRKFMAANWDKDEGE--INLLEDCSTMIINTA 165 Query: 193 AKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQ 252 + FG + L A++ +Q + M + + L L Q E+ L++ Sbjct: 166 CQCLFGEDLRKRLDARR-FAQLLAKMESSLIPAAVFLPILLKLPLPQSARCHEARTELQK 224 Query: 253 VGRDWVQRRREALKRGEEVPADILTQILKA---EEGAQDDEGLLDNFVTFFIAGHETSAN 309 + + + R+ A + +D+L+ +L A + + V AG TS+ Sbjct: 225 ILSEIIIARKAAAVNKDSSTSDLLSGLLSAVYRDGTPMSLHEVCGMIVAAMFAGQHTSSI 284 Query: 310 HLAFTVMELSRQPEIVARLQA---EVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPP 366 ++++ L P V L+A E++E Y + D + + + +ES+R PP Sbjct: 285 TTTWSMLHL-MHPANVKHLEALRKEIEEFPAQLNYNNVMD--EMPFAERCARESIRRDPP 341 Query: 367 AWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFT 426 R + + + VP + S + + F +P ++P+R K Sbjct: 342 LLMLMRKVMADVKVGSYVVPKGDIIACSPLLSHHDEEAFPEPRRWDPER----DEKVEGA 397 Query: 427 YFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLV 463 + F G CIGQ+F ++VK ++A + +F+L+ Sbjct: 398 FIGFGAGVHKCIGQKFGLLQVKTILATAFRSYDFQLL 434 >2VZM-A nrPDB Length = 436 Score = 55.1 bits (131), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 54/208 (25%), Positives = 89/208 (42%), Gaps = 33/208 (15%) Query: 266 KRGEEVPADILTQILKA--EEGAQ-DDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQP 322 KRG++ D+L+ +++ E+G++ E LL +AGHET+ N +A + L P Sbjct: 225 KRGQDG-EDLLSALVRTSDEDGSRLTSEELLGMAHILLVAGHETTVNLIANGMYALLSHP 283 Query: 323 EIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPA-WGTFRLLEEETLID 381 + +A L+A+ + L ++E LR P T+R E +D Sbjct: 284 DQLAALRAD------------------MTLLDGAVEEMLRYEGPVESATYRFPVEPVDLD 325 Query: 382 GVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQ 441 G +P +L R F DP F+ R G + F G CIG Sbjct: 326 GTVIPAGDTVLVVLADAHRTPERFPDPHRFDIRRDTAG-------HLAFGHGIHFCIGAP 378 Query: 442 FAQMEVKVVMAKLLQR---LEFRLVPGQ 466 A++E ++ + LL+R L + PG+ Sbjct: 379 LARLEARIAVRALLERCPDLALDVSPGE 406 >5IT1-A nrPDB Length = 399 Score = 54.7 bits (130), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 48/187 (25%), Positives = 83/187 (44%), Gaps = 26/187 (13%) Query: 274 DILTQILKAEE--GAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAE 331 D+++ ++ E+ G DD L++ T IA H+T+A + L +P+ +A LQ + Sbjct: 207 DLISALITTEDPDGVIDDMFLMNAAGTLLIAAHDTTACMIGLGTALLLDRPDQLALLQKD 266 Query: 332 VDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPL 391 +IG+ E+L R + Q +G R+ ++ I GVR+ + Sbjct: 267 -PSLIGNA----VEELLRYLTIGQ------------FGAERVATQDGEIGGVRIAKGEQV 309 Query: 392 LFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVM 451 + + EDP F+ R P P + F G CIGQQ A++E+++V Sbjct: 310 VTHLLSADFDPAFVEDPERFDITR----RPAP---HLAFGFGAHQCIGQQLARIELQIVF 362 Query: 452 AKLLQRL 458 L +R Sbjct: 363 GTLFRRF 369 >5YSW-A nrPDB Length = 441 Score = 54.7 bits (130), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 51/191 (26%), Positives = 87/191 (45%), Gaps = 35/191 (18%) Query: 274 DILTQILK---AEEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQA 330 DI++ ++ A+ DDE L++ IAG++T+A+ L + L ++P +A L+ Sbjct: 247 DIISGLIHHAGADPALTDDE-LINIANLLLIAGYDTTASMLGLGIFVLLQRPAQLATLRD 305 Query: 331 EVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTP 390 + + + L L+YLS V G FR +E+ G +P + Sbjct: 306 DPSRIADAVEEL-------LRYLSVVNP----------GIFRFAKEDLEFAGEHIPAGST 348 Query: 391 LLFSTYVMGRMDTYFEDP---LTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEV 447 ++ S R ++ DP LT +PR + F G C+GQQ A+ME+ Sbjct: 349 VVVSVVATNRDARHWPDPDLDLT-----------RPRGPHLAFGHGVHQCLGQQLARMEM 397 Query: 448 KVVMAKLLQRL 458 + A+LL+RL Sbjct: 398 QAGYAELLRRL 408 >1ODO-A nrPDB Length = 408 Score = 54.3 bits (129), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 95/412 (23%), Positives = 163/412 (39%), Gaps = 74/412 (17%) Query: 69 KKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKM-YRALQTVFGERLFGQGLVS 127 ++ GP V+V + V+ P +K+ L S+ +KD++ + A V G + Sbjct: 25 REGGPATWVDVLGVQAWSVSDPVLLKQLLTSSDVSKDARAHWPAFGEVVGTWPLALWVAV 84 Query: 128 ECNYERW----HKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDM 183 E + + K RR++ AFS + ++ LV+ L G+ PV ++ Sbjct: 85 ENMFTAYGPNHRKLRRLVAPAFSARRVDAMRPAVEAMVTGLVDRLAELPAGE-PVDLRQE 143 Query: 184 LTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREV 243 L Y L A G L+G + + +++G+ + A+ +L EV Sbjct: 144 LAYP----LPIAVIG----HLMGVPQDRRDGFRALVDGVFDTTLDQAEA-QANTARLYEV 194 Query: 244 RESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDEG---------LLD 294 + + A KR P D +T +L A A+DDEG L D Sbjct: 195 LDQLI---------------AAKRA--TPGDDMTSLLIA---ARDDEGDGDRLSPEELRD 234 Query: 295 NFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLS 354 + AG+ET+ N + V L +P+ +A ++ G + + + Sbjct: 235 TLLLMISAGYETTVNVIDQAVHTLLTRPDQLALVRK-----------------GEVTW-A 276 Query: 355 QVLKESLRLYPPAWGTFRL---LEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTF 411 V++E+LR + PA L + + L DG + P+L S R + ED TF Sbjct: 277 DVVEETLR-HEPAVKHLPLRYAVTDIALPDGRTIARGEPILASYAAANRHPDWHEDADTF 335 Query: 412 NPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRL-EFRL 462 + A + + F G C+G A+MEV + + L R + RL Sbjct: 336 D-------ATRTVKEHLAFGHGVHFCLGAPLARMEVTLALESLFGRFPDLRL 380 >4MM0-A nrPDB Length = 399 Score = 53.5 bits (127), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 54/199 (27%), Positives = 89/199 (44%), Gaps = 33/199 (16%) Query: 264 ALKRGEEVPADILTQILK--AEEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQ 321 A KR E +D+L+ ++ AE+ D + + +AG+E ++N L +V+ L R Sbjct: 197 AAKR-ENPGSDLLSALVATAAEDNELTDHDVRSLSLILLLAGYEPASNQLGSSVLTLLRF 255 Query: 322 PEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGT-FRLLEEETLI 380 P+ +A L+ D G L ++E +R P G FR+ E+ I Sbjct: 256 PDRLAELR---------------RDPG---LLPSAVEELMRYAPAGDGALFRVTLEDVTI 297 Query: 381 DGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGH--RSCI 438 +P N+ +L ST F+DP DR P + T +LGH C+ Sbjct: 298 GDTHIPANSAVLASTQAANWDPRRFDDPTGLRLDR-----PDNQHT----ALGHGIHFCL 348 Query: 439 GQQFAQMEVKVVMAKLLQR 457 G A++E++V + LL+R Sbjct: 349 GAALARVELQVAIGALLRR 367 >2WIY-A nrPDB Length = 394 Score = 52.8 bits (125), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 56/223 (25%), Positives = 83/223 (37%), Gaps = 32/223 (14%) Query: 260 RRREALKRGEEVPADILTQIL--KAEEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVME 317 R E L+ P D L L A G + + + F+ GH +A + Sbjct: 189 RVAEMLEDKRVNPGDGLADSLLDAARAGEITESEAIATILVFYAVGHMAIGYLIASGIEL 248 Query: 318 LSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEE 377 +R+PE+ + DE S R + ++ E +R+ PP R E+ Sbjct: 249 FARRPEVFTAFRN--DE---SAR-------------AAIINEMVRMDPPQLSFLRFPTED 290 Query: 378 TLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSC 437 I GV + +P+ F R F+DP F+ R P F LG SC Sbjct: 291 VEIGGVLIEAGSPIRFMIGAANRDPEVFDDPDVFDHTR-----PPAASRNLSFGLGPHSC 345 Query: 438 IGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLD 480 GQ ++ E V A L +R E R L E+ T+ D Sbjct: 346 AGQIISRAEATTVFAVLAERYE-------RIELAEEPTVAHND 381 >5Y1I-A nrPDB Length = 403 Score = 52.8 bits (125), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 52/196 (26%), Positives = 95/196 (48%), Gaps = 29/196 (14%) Query: 266 KRGEEVPADILTQILKAEEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIV 325 RG+++ +D+ Q+ +A E QDD + + AGHET+AN +A + L PE + Sbjct: 204 DRGDDILSDLAVQV-EAGEITQDDAAGIG--MMLLGAGHETTANMIALGTLALLENPEQL 260 Query: 326 ARLQAEVD-EVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVR 384 A ++ D +VI + E+L L+YL+ + ++++R R+ E+ I GV Sbjct: 261 AEVRDSDDPKVIVNT----VEEL--LRYLT-IAQDTVR---------RIAAEDIEIGGVV 304 Query: 385 VPGNTPLLFSTYVMGRMDTYFEDPLTF--NPDRFGPGAPKPRFTYFPFSLGHRSCIGQQF 442 + ++F ++ DP + PDR R + F G C+G Sbjct: 305 IKAGEGIVFP------LNAANWDPDLYPEAPDRLDIHRANAR-RHLAFGYGVHQCLGATL 357 Query: 443 AQMEVKVVMAKLLQRL 458 A++E+++V + LL+R+ Sbjct: 358 ARVELQIVYSTLLRRI 373 >5CJE-A nrPDB Length = 393 Score = 52.4 bits (124), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 50/192 (26%), Positives = 73/192 (38%), Gaps = 30/192 (15%) Query: 271 VPADILTQILKAEEGAQDD----EGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVA 326 PAD L L DD E L +AGHET+ N + V L P+ +A Sbjct: 198 APADDLLGDLIRTRAEDDDRLSGEELRAMAFILLVAGHETTVNLITNGVHTLLTHPDQLA 257 Query: 327 RLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPA-WGTFRLLEEETLIDGVRV 385 L+A+ + L ++E LR P T+R E I G + Sbjct: 258 ALRAD------------------MTLLDGAVEEVLRFEGPVETATYRYAAESMEIGGTAI 299 Query: 386 PGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQM 445 P++ GR DP F+ R AP+ + F G C+G A++ Sbjct: 300 AEGDPVMIGLDAAGRDPARHPDPHVFDIHR----APQ---GHLAFGHGIHYCLGAPLARL 352 Query: 446 EVKVVMAKLLQR 457 E +V + LL+R Sbjct: 353 EARVALRSLLER 364 >5XW2-A nrPDB Length = 419 Score = 52.0 bits (123), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 53/221 (23%), Positives = 92/221 (41%), Gaps = 43/221 (19%) Query: 243 VRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDEGLLDNFVTFF-- 300 +R+ + +LR+ + +R R D++ ++++AE D L DN + F Sbjct: 205 MRKMLEYLREHAAECRRRPR----------GDLMGKLIEAE---VDGRRLTDNHIVNFAK 251 Query: 301 ---IAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVL 357 IAG+ T+ + TV+ L PE AR++A+ + G +L Sbjct: 252 MLLIAGYLTTTMLIGNTVLCLDSYPEQAARVRADRSLIPG------------------LL 293 Query: 358 KESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFG 417 +ES+R P T+R + + G R+ + ++ R F +P F+ R Sbjct: 294 EESMRFLSPVAATYRATTRDVEVAGQRLSADQMVMVWFGAANRDARQFAEPELFDMTR-- 351 Query: 418 PGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRL 458 P P + F G C+G A+ME +V + LL R Sbjct: 352 --GPNP---HLGFGRGIHFCLGGPLARMEGRVALDHLLDRF 387 >3R9C-A nrPDB Length = 418 Score = 52.0 bits (123), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 55/217 (25%), Positives = 86/217 (39%), Gaps = 34/217 (15%) Query: 249 FLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQD--DEGLLDNFVTFFIAGHET 306 +LR R + RR GE D+++ ++ EE ++ ++ IAGHET Sbjct: 207 WLRDYLRALIDERRR--TPGE----DLMSGLVAVEESGDQLTEDEIIATCNLLLIAGHET 260 Query: 307 SANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPP 366 + N +A + + R P A L A+ GS+ S V++E++R PP Sbjct: 261 TVNLIANAALAMLRTPGQWAALAAD-----GSR-------------ASAVIEETMRYDPP 302 Query: 367 AWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFT 426 R ++ I VP +L R T P F+PDR + Sbjct: 303 VQLVSRYAGDDLTIGTHTVPKGDTMLLLLAAAHRDPTIVGAPDRFDPDRA-------QIR 355 Query: 427 YFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRL-EFRL 462 + F G C+G A++E V + L R E RL Sbjct: 356 HLGFGKGAHFCLGAPLARLEATVALPALAARFPEARL 392 >5VWS-A nrPDB Length = 393 Score = 51.6 bits (122), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 72/341 (21%), Positives = 132/341 (38%), Gaps = 52/341 (15%) Query: 121 FGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSM 180 FG+G ++ + QRR+I AF+ S+ ++ + A+ L++ L + Sbjct: 73 FGKGGITMIDPPEHRHQRRLITHAFTPQSISAMEPRIRQIADHLLDELPGPE-----FDL 127 Query: 181 QDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQL 240 + Y I+ G+ + + + L +E LA+ + ++ Sbjct: 128 VEHFAYPLPVIVIAELLGVPPGDRHLFRTWSDRLMSLQVENYADPE--LARTVAAAMTEM 185 Query: 241 RE-VRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAE-EGAQDD-EGLLDNFV 297 + +RE R R RD D+LT++++AE EG + D E +++ Sbjct: 186 NDYLREHCRSRRTHPRD-----------------DLLTRLVQAEVEGKRLDLEEVVNTAS 228 Query: 298 TFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVL 357 +AGH T+ + T++ L PE ++A+ + L Sbjct: 229 LLLLAGHLTTTVLIGNTMLCLWDHPEAEKAVRADP------------------SLIPAAL 270 Query: 358 KESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFG 417 +ESLRL P R+ + I G +P N ++ D F DP F+ R Sbjct: 271 EESLRLRSPFLQAGRVTTRDVTIAGETIPANRFVMAWILSANHDDRRFPDPERFDLHRQT 330 Query: 418 PGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRL 458 G + F G C+G Q ++E ++ + +LL R Sbjct: 331 TG-------HIAFGHGVHFCLGAQLGRLEGRIALERLLGRF 364 >3ABA-A nrPDB Length = 403 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 49/198 (24%), Positives = 85/198 (42%), Gaps = 31/198 (15%) Query: 274 DILTQILKAEE--GAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAE 331 D+++ ++ E+ G DD L++ T IA H+T+A + L P+ +A L+ E Sbjct: 207 DLISALITTEDPDGVVDDMFLMNAAGTLLIAAHDTTACMIGLGTALLLDSPDQLALLR-E 265 Query: 332 VDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPL 391 ++G+ E+L R + Q +G R+ + + GVR+ + Sbjct: 266 DPSLVGNA----VEELLRYLTIGQ------------FGGERVATRDVELGGVRIAKGEQV 309 Query: 392 LFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVM 451 + + E+P F+ R P P + F G CIGQQ A++E+++V Sbjct: 310 VAHVLAADFDPAFVEEPERFDITR----RPAP---HLAFGFGAHQCIGQQLARIELQIVF 362 Query: 452 AKLLQRLEFRLVPGQRFG 469 L +RL PG R Sbjct: 363 ETLFRRL-----PGLRLA 375 >6DCD-A nrPDB Length = 424 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 53/200 (26%), Positives = 82/200 (41%), Gaps = 32/200 (16%) Query: 299 FFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLK 358 F AG ET+A L + L +P+I RL+ R L + ++ Sbjct: 249 LFAAGQETTAKLLTAAMRVLGDRPDIQRRLR--------ENRSL----------IPNFIE 290 Query: 359 ESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGP 418 ESLR+ P RL + T + G+ + T ++ R FEDP F DR Sbjct: 291 ESLRMDSPVKSDSRLARKRTTVGGLDIAAGTVVMVLPGAANRDPRRFEDPHEFRLDR--- 347 Query: 419 GAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRL------EFRLVPG--QRFGL 470 P R + F+ G SC G A++E +V + ++L R+ E R P +R+ Sbjct: 348 --PNVR-EHMAFARGVHSCPGGPLARVEGRVSLERILDRMLDIAINEDRHGPADDRRYTY 404 Query: 471 QEQATLKPLDPVLCTLRPRG 490 + L+ L + T P G Sbjct: 405 EPTYILRGLTELHITFTPAG 424 >3NC3-A nrPDB Length = 441 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 44/192 (22%), Positives = 85/192 (44%), Gaps = 25/192 (13%) Query: 273 ADILTQILKAE-EG-AQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQA 330 +D+++ + +E EG A D+ +L + +A E + LA + L PE Sbjct: 238 SDLISILCTSEYEGMALSDKDILALILNVLLAATEPADKTLALMIYHLLNNPE------- 290 Query: 331 EVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTP 390 ++++V+ + + + + E+LR PP R L ++T++ G+ + +T Sbjct: 291 QMNDVLADR-----------SLVPRAIAETLRYKPPVQLIPRQLSQDTVVGGMEIKKDTI 339 Query: 391 LLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFT----YFPFSLGHRSCIGQQFAQME 446 + R FE P FN R G K F+ + F G +C+G FA+ E Sbjct: 340 VFCMIGAANRDPEAFEQPDVFNIHREDLGI-KSAFSGAARHLAFGSGIHNCVGTAFAKNE 398 Query: 447 VKVVMAKLLQRL 458 +++V +L ++ Sbjct: 399 IEIVANIVLDKM 410 >4Z5P-A nrPDB Length = 400 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 58/223 (26%), Positives = 91/223 (40%), Gaps = 48/223 (21%) Query: 256 DWVQRRREALKRGEEVPADILTQILKAEEGAQDDEGLL--DNFVTF----FIAGHETSAN 309 D V RR A P D L +L + A+DD+ L D +TF +AGHETSA+ Sbjct: 195 DLVSARRAA-------PHDDLLGVLVS---ARDDDDRLTEDELITFGVTLLVAGHETSAH 244 Query: 310 HLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYP--PA 367 L V L + ++ L+ + + L + ++E LR P Sbjct: 245 QLGNMVYALLTHEDQLSLLREQP------------------ELLPRAVEELLRFVPLGNG 286 Query: 368 WGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTY 427 G R+ E+ + G V ++ + R F+DP DR + + + Sbjct: 287 VGNARIALEDVELSGGTVRAGEGVVAAAVNANRDPRAFDDP-----DRLD--ITREKNPH 339 Query: 428 FPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGL 470 F G C+G Q A+ME++V + LL+R PG R + Sbjct: 340 LAFGHGAHYCLGAQLARMELRVAIGGLLERF-----PGLRLAV 377 >5LIV-A nrPDB Length = 450 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 39/172 (22%), Positives = 73/172 (42%), Gaps = 25/172 (14%) Query: 297 VTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQV 356 ++ + G+ET++ +A T+ L P+ +AR++ + L Sbjct: 274 LSLILGGYETTSWLVANTIHALLAHPDTLARVRQDP------------------SLLPAA 315 Query: 357 LKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRF 416 ++E +R P ++G R++E + +D + T + + +T + P ++ DR Sbjct: 316 IEEGMRWCPSSFGVLRMVERDVRLDDQALSAGTVVCLAGIAGNYDETAYPSPEVYDIDR- 374 Query: 417 GPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLE-FRLVPGQR 467 KP F G C+G A+ME +V + LL R R VP +R Sbjct: 375 -----KPLPAANVFGGGAHFCVGAPLARMEARVGLQALLARFPGLRAVPEER 421 >5OFQ-A nrPDB Length = 409 Score = 49.7 bits (117), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 52/245 (21%), Positives = 103/245 (42%), Gaps = 41/245 (16%) Query: 238 KQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQD--DEGLLDN 295 K +++ E + FL+ ++ + R++ + D+++ +L+AE + +E +L Sbjct: 181 KMMQKRNEGVIFLQGYFKEIIAERQQNKQE------DLISLLLEAEIDGEHLTEEEVLGF 234 Query: 296 FVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQ 355 + +AG+ET+ N + V ++ ++ ++ ++ V Sbjct: 235 CILLLVAGNETTTNLITNGVRYMTEDVDVQNEVRRDISLV------------------PN 276 Query: 356 VLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDR 415 +++E+LR YPP R+ E+ + ++ ++ R FE P TF R Sbjct: 277 LVEETLRYYPPIQAIGRIAAEDVELGECKIKRGQQVISWAASANRDSAKFEWPDTFVVHR 336 Query: 416 FGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQAT 475 P + F G C+G A+ME K+ KLL++ F V Q + Sbjct: 337 ----KTNPHVS---FGFGIHFCLGAPLARMEGKIAFTKLLEKGGFSKVQNQ--------S 381 Query: 476 LKPLD 480 LKP+D Sbjct: 382 LKPID 386 >4OQR-A nrPDB Length = 457 Score = 48.9 bits (115), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 47/188 (25%), Positives = 74/188 (39%), Gaps = 29/188 (15%) Query: 289 DEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLG 348 DE L + + +AGHET+AN L L + PE +A L + D V RYL LG Sbjct: 266 DEELTNIALILLVAGHETTANMLGLGTFALLQHPEQIANLDSP-DAVEELLRYLSIVHLG 324 Query: 349 RLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDP 408 R E+ ++G + + + R F++P Sbjct: 325 TPN--------------------RAALEDVELEGQMIRKGDTVAIGLPAVNRDPKVFDEP 364 Query: 409 LTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRL-EFRL-VPGQ 466 DR + F G C+GQQ A++E+++ +L R RL VP + Sbjct: 365 DILQLDRVD------ARKHAAFGGGIHQCLGQQLARVEMRIGFTRLFARFPSLRLAVPAE 418 Query: 467 RFGLQEQA 474 L+E++ Sbjct: 419 EIKLREKS 426 >6F88-A nrPDB Length = 400 Score = 48.9 bits (115), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 39/172 (22%), Positives = 72/172 (41%), Gaps = 25/172 (14%) Query: 297 VTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQV 356 ++ + G+ET++ +A T+ L P+ +AR++ + L Sbjct: 224 LSLILGGYETTSWLVANTIHALLAHPDTLARVRQDP------------------SLLPAA 265 Query: 357 LKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRF 416 ++E +R P +G R++E + +D + T + + +T + P ++ DR Sbjct: 266 IEEGMRWCPSNFGVLRMVERDVRLDDQALSAGTVVCLAGIAGNYDETAYPSPEVYDIDR- 324 Query: 417 GPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLE-FRLVPGQR 467 KP F G C+G A+ME +V + LL R R VP +R Sbjct: 325 -----KPLPAANVFGGGAHFCVGAPLARMEARVGLQALLARFPGLRAVPEER 371 >2WIO-A nrPDB Length = 431 Score = 48.9 bits (115), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 49/188 (26%), Positives = 82/188 (43%), Gaps = 27/188 (14%) Query: 274 DILTQILKAE-EG-AQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAE 331 D++++++ AE +G A DDE + +AGH T+ L V L P A A Sbjct: 231 DLISRLVLAEVDGRALDDEEAANFSTALLLAGHITTTVLLGNIVRTLDEHP---AHWDAA 287 Query: 332 VDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPL 391 ED GR+ +++E LR PP R + T + GV +P + + Sbjct: 288 A------------EDPGRI---PAIVEEVLRYRPPFPQMQRTTTKATEVAGVPIPAD--V 330 Query: 392 LFSTYVM-GRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVV 450 + +T+V+ D+ D +PDRF P F G C+G A++E +V Sbjct: 331 MVNTWVLSANRDSDAHD----DPDRFDPSRKSGGAAQLSFGHGVHFCLGAPLARLENRVA 386 Query: 451 MAKLLQRL 458 + +++ R Sbjct: 387 LEEIIARF 394 >1CPT-A nrPDB Length = 428 Score = 48.5 bits (114), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 38/172 (22%), Positives = 74/172 (43%), Gaps = 25/172 (14%) Query: 288 DDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDL 347 DD+ + +V AGH+T+++ ++ LSR PE +A +++ Sbjct: 253 DDKYINAYYVAIATAGHDTTSSSSGGAIIGLSRNPEQLALAKSDP--------------- 297 Query: 348 GRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFED 407 + +++ E++R P R +T + G + ++ S R + F + Sbjct: 298 ---ALIPRLVDEAVRWTAPVKSFMRTALADTEVRGQNIKRGDRIMLSYPSANRDEEVFSN 354 Query: 408 PLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLE 459 P F+ RF P + F G C+GQ A++E+K+ +LL +L+ Sbjct: 355 PDEFDITRF----PN---RHLGFGWGAHMCLGQHLAKLEMKIFFEELLPKLK 399 >4TRI-A nrPDB Length = 407 Score = 48.5 bits (114), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 46/196 (23%), Positives = 83/196 (42%), Gaps = 29/196 (14%) Query: 266 KRGEEVPADILTQILKAEEGAQ---DDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQP 322 KR E D+ + ++ +E Q DDE + + + I G ET+ + L+ +L R Sbjct: 195 KRRAEPTDDLFSVLVNSEVEGQRMSDDEIVFETLL-ILIGGDETTRHTLSGGTEQLLRHR 253 Query: 323 EIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDG 382 + L A+VD + G+ ++E LR P R L +T+ G Sbjct: 254 DQWDALVADVDLLPGA------------------IEEMLRWTSPVKNMCRTLTADTVFHG 295 Query: 383 VRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQF 442 + ++ ++ F DP F DR P ++ F G C+G Q Sbjct: 296 TELRAGEKIMLMFESANFDESVFGDPDNFRIDR------NPN-SHVAFGFGTHFCLGNQL 348 Query: 443 AQMEVKVVMAKLLQRL 458 A++E++++ ++L+RL Sbjct: 349 ARLELRLMTERVLRRL 364 >3TKT-A nrPDB Length = 450 Score = 48.1 bits (113), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 38/165 (23%), Positives = 74/165 (44%), Gaps = 27/165 (16%) Query: 296 FVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQ 355 ++ AGH+T++ A + L+R P++ AR++A+ + L Sbjct: 283 YIITASAGHDTTSASSAGAALALARDPDLFARVKADRN------------------LLPG 324 Query: 356 VLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMD-TYFEDPLTFNPD 414 +++E++R P R +T + G ++ L+ + YV D F +P F+P Sbjct: 325 IVEEAIRWTTPVQHFMRTAATDTELCGQKIAAGDWLMLN-YVAANHDPAQFPEPRKFDPT 383 Query: 415 RFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLE 459 R P + F G C+G A++E++V++ LL R++ Sbjct: 384 R-------PANRHLAFGAGSHQCLGLHLARLEMRVLLDVLLDRVD 421 >6GII-A nrPDB Length = 479 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 29/120 (24%), Positives = 51/120 (42%), Gaps = 6/120 (5%) Query: 358 KESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFG 417 +E LR P G R E ++GVR+P +L +F+DP F+ R Sbjct: 346 EECLRYNGPVAGWRRRTTREVEVEGVRLPVGANILMVVASANHDSAHFDDPEFFDIGRSN 405 Query: 418 PGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLK 477 + F G C+G+ +ME+++++ +L +RL + QRF + + Sbjct: 406 AS------EHLNFGYGAHQCLGRNLGRMEMQIMIEELSRRLPHMRLAEQRFDYLHNVSFR 459 >4OQS-A nrPDB Length = 433 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 47/188 (25%), Positives = 74/188 (39%), Gaps = 29/188 (15%) Query: 289 DEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLG 348 DE L + + +AGHET+AN L L + PE +A L + D V RYL LG Sbjct: 227 DEELTNIALLLLVAGHETTANMLGLGTFALLQHPEQIAALDSP-DAVEELLRYLSIVHLG 285 Query: 349 RLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDP 408 R E+ ++G + + + R F++P Sbjct: 286 TPN--------------------RAALEDVELEGQMIRKGDTVAIGLPAVNRDPKVFDEP 325 Query: 409 LTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRL-EFRL-VPGQ 466 DR + F G C+GQQ A++E+++ +L R RL VP + Sbjct: 326 DILQLDRVD------ARKHAAFGGGIHQCLGQQLARVEMRIGFTRLFARFPSLRLAVPAE 379 Query: 467 RFGLQEQA 474 L+E++ Sbjct: 380 EIKLREKS 387 >6GK6-A nrPDB Length = 411 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 52/188 (27%), Positives = 79/188 (42%), Gaps = 28/188 (14%) Query: 274 DILTQILKAEEGAQD-DEGLLDNFV-TFFIAGHETSANHLAFTVMELSRQPEIVARLQAE 331 D+++ +L AEE L + V +AGHET+ + +A ++ L P Sbjct: 213 DLISGLLLAEEQEHKLSPAELSSMVFLLLVAGHETTVHLIASGMLLLLSHP--------- 263 Query: 332 VDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPA-WGTFRLLEEETLIDGVRVPGNTP 390 +R LD ED G + ++E+LR PA T R E+ + G RVP Sbjct: 264 -----AERRRLD-EDPG---LVGSAVEEALRCEGPAELSTIRWSLEDIELFGARVPAGEG 314 Query: 391 LLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVV 450 + R +F D PDRF G R + F G C+G A++E + Sbjct: 315 VAAGLLAANRDPQHFPD-----PDRFDIGRSPNR--HIGFGGGIHFCLGAMLARIEAAIA 367 Query: 451 MAKLLQRL 458 + LL+RL Sbjct: 368 FSTLLRRL 375 >6CVC-A nrPDB Length = 433 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 45/191 (23%), Positives = 83/191 (43%), Gaps = 31/191 (16%) Query: 273 ADILTQILKAEEGAQDDEGLLDN-----FVTFFIAGHETSANHLAFTVMELSRQPEIVAR 327 D+ T +++AE D E L + F+ +AG+ET+ N ++ ++ LSR P+ A Sbjct: 240 GDLTTSLVEAE---VDGERLSSSEIAMFFILLVVAGNETTRNAISHGMLALSRYPDERA- 295 Query: 328 LQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPG 387 K + DF+ L + ++E +R P R L ++ + G ++ Sbjct: 296 -----------KWWSDFDGLA-----ATAVEEIVRWASPVVYMRRTLSQDVDLRGTKMAA 339 Query: 388 NTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEV 447 + R + F DP TF+ R P P+ + G C+G A+ E+ Sbjct: 340 GDKVTLWYCSANRDEEKFADPWTFDVTR----NPNPQVGF--GGGGAHFCLGANLARREI 393 Query: 448 KVVMAKLLQRL 458 +VV +L +++ Sbjct: 394 RVVFDELRRQM 404 >3RWL-A nrPDB Length = 426 Score = 46.6 bits (109), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 44/215 (20%), Positives = 85/215 (39%), Gaps = 37/215 (17%) Query: 257 WVQRRREALK-----------RGEEVPADILTQILKAEEGAQD--DEGLLDNFVTFFIAG 303 W QR+ E L+ R + P + L +L ++ E L N + + G Sbjct: 207 WDQRKTELLECAAYFQVLWNERVNKDPGNDLISMLAHSPATRNMTPEEYLGNVLLLIVGG 266 Query: 304 HETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRL 363 ++T+ N + V+ L + P+ A+L+A + ++ E +R Sbjct: 267 NDTTRNSMTGGVLALHKNPDQFAKLKANP------------------ALVETMVPEIIRW 308 Query: 364 YPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKP 423 P R ++ + G + ++ Y R D + P F DR P+P Sbjct: 309 QTPLAHMRRTAIADSELGGKTIRKGDKVVMWYYSGNRDDEVIDRPEEFIIDR-----PRP 363 Query: 424 RFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRL 458 R + F G C+G + A+M+++++ ++L R Sbjct: 364 R-QHLSFGFGIHRCVGNRLAEMQLRILWEEILTRF 397 >3SN5-A nrPDB Length = 491 Score = 46.6 bits (109), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 61/247 (24%), Positives = 96/247 (38%), Gaps = 36/247 (14%) Query: 261 RREALKRGEEVPADILTQILKAEEGAQDDEGLLDNFVTFFIAGHETSANHLAFT---VME 317 R E L++ E + I ++ + + D+ L+ T + + AN + T + + Sbjct: 226 RHENLQKRESISELISLRMFLNDTLSTFDD--LEKAKTHLVVLWASQANTIPATFWSLFQ 283 Query: 318 LSRQPEIVARLQAEVDEVI----------GSKRYLDFEDLGRLQYLSQVLKESLRLYPPA 367 + R PE + EV + G+ L +L L L ++KESLRL + Sbjct: 284 MIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSAS 343 Query: 368 WGTFRLLEEETLI--DG-VRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDR--------- 415 E+ TL DG + + + +M + DPLTF DR Sbjct: 344 LNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTK 403 Query: 416 --FGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQ 473 F K ++ Y PF G C G+ FA E+K + +L E L+ G Q Sbjct: 404 TTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEG-------Q 456 Query: 474 ATLKPLD 480 A PLD Sbjct: 457 AKCPPLD 463 >1EHE-A nrPDB Length = 403 Score = 45.4 bits (106), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 45/188 (23%), Positives = 76/188 (40%), Gaps = 26/188 (13%) Query: 274 DILTQIL--KAEEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAE 331 DI++++ + + G D + +AG+ T N +A V L++ P+ +A+L+A Sbjct: 209 DIISKLCTEQVKPGNIDKSDAVQIAFLLLVAGNATMVNMIALGVATLAQHPDQLAQLKAN 268 Query: 332 VDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPL 391 S E+L R S A R +E+ +I V N + Sbjct: 269 -----PSLAPQFVEELCRYHTAS------------ALAIKRTAKEDVMIGDKLVRANEGI 311 Query: 392 LFSTYVMGRMDTYFEDPLTFNPDR-FGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVV 450 + S R + FE+P FN +R + P P F G CI + A+ E+ V Sbjct: 312 IASNQSANRDEEVFENPDEFNMNRKWPPQDP------LGFGFGDHRCIAEHLAKAELTTV 365 Query: 451 MAKLLQRL 458 + L Q+ Sbjct: 366 FSTLYQKF 373 >2NZA-A nrPDB Length = 413 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 32/119 (26%), Positives = 52/119 (43%), Gaps = 9/119 (7%) Query: 369 GTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYF 428 G R+ E+ + G R+ P+ S R F DP + DR P P Y Sbjct: 295 GLARIALEDVEVHGTRIAAGEPVYVSYLAANRDPDVFPDPDRIDLDR----DPNPHLAY- 349 Query: 429 PFSLGHRSCIGQQFAQMEVKVVMAKLLQRLE-FRL-VPGQRFGLQEQATLKPLDPVLCT 485 GH C G A+M+ ++++ LL+RL RL VP ++ + + ++ + CT Sbjct: 350 --GNGHHFCTGAVLARMQTELLVDTLLERLPGLRLAVPAEQVAWRRKTMIRGPRTLPCT 406 >4C9K-A nrPDB Length = 421 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 53/205 (25%), Positives = 86/205 (41%), Gaps = 55/205 (26%) Query: 274 DILTQILKAEEGAQD--DEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVA----- 326 D++T+IL E + D+ L + G +T N L F ++ LSR PE VA Sbjct: 226 DLITRILNVEIDGKPMPDDRALGLVSLLLLGGLDTVVNFLGFMMIYLSRHPETVAEMRRE 285 Query: 327 --RLQAEVDE------VIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEET 378 +LQ V+E V+ RY+ + +++ +LKE Sbjct: 286 PLKLQRGVEELFRRFAVVSDARYV----VSDMEFHGTMLKE------------------- 322 Query: 379 LIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCI 438 G+ +L T + G D + +DP+T + R T+ F+ G C Sbjct: 323 --------GDL-ILLPTALHGLDDRHHDDPMTVDLSRRD-------VTHSTFAQGPHRCA 366 Query: 439 GQQFAQMEVKVVMAKLLQRL-EFRL 462 G A++EV V++ + L R+ EFRL Sbjct: 367 GMHLARLEVTVMLQEWLARIPEFRL 391 >5KYO-A nrPDB Length = 430 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 59/254 (23%), Positives = 107/254 (42%), Gaps = 53/254 (20%) Query: 238 KQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQ--DDEGLLDN 295 KQ RE +LR V ++ RR +K GE D++++++ E G + D + Sbjct: 220 KQFRE------YLRPV----IEARR--IKPGE----DMISRMINGEVGGRPLTDIEAENI 263 Query: 296 FVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQ 355 + + G +T N L FT L++ + + A+ + Sbjct: 264 CIQVLVGGLDTVVNMLGFTFSHLAKDHALRRAIAADP------------------SLIDD 305 Query: 356 VLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDR 415 L E R +P +L ++ +GV + ++ T V+ D EDPL F R Sbjct: 306 ALLEFFRRFPVVSSAREVLRDQEF-EGVLLKAGDMVMAPTVVVAMDDARNEDPLEF---R 361 Query: 416 FGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRL-EFRLVPGQRFGLQEQA 474 G A + + F G +C G A+ME+KVV+ + R+ EFR +++ A Sbjct: 362 LGRKARQ----HSTFGKGSHTCPGAHLARMEMKVVLREWFARIPEFR--------IEDDA 409 Query: 475 TLKPLDPVLCTLRP 488 L+ + ++ +++P Sbjct: 410 PLRYSNGIVGSVKP 423 >2WM5-A nrPDB Length = 435 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 38/163 (23%), Positives = 67/163 (41%), Gaps = 23/163 (14%) Query: 296 FVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQ 355 F+ +AG+ET+ N + V+ LSR PE R + DF+ L Sbjct: 268 FILLVVAGNETTRNAITHGVLALSRYPEQRDRW------------WSDFDGLA-----PT 310 Query: 356 VLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDR 415 ++E +R P R L ++ + G ++ + R ++ F DP TF+ R Sbjct: 311 AVEEIVRWASPVVYMRRTLTQDIELRGTKMAAGDKVSLWYCSANRDESKFADPWTFDLAR 370 Query: 416 FGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRL 458 P P + G C+G A+ E++V +L +++ Sbjct: 371 ----NPNPHLGF--GGGGAHFCLGANLARREIRVAFDELRRQM 407 >5NWS-A nrPDB Length = 435 Score = 43.1 bits (100), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 93/429 (21%), Positives = 165/429 (38%), Gaps = 90/429 (20%) Query: 59 VLQDVFLDWAK--KYGPVVRVNVFHKTSV-IVTSPESVKKFLMSTKY------------- 102 +L D F + + + GPVVR T V VT + V+ L ++ Sbjct: 32 LLADPFTGYGRLRERGPVVRGRFVDGTPVWFVTRYDDVRAVLRDPRFVNTPSPVPGEGGA 91 Query: 103 NKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAE 162 + M L R++ G + + + + RR++ AF+ ++ L A+ Sbjct: 92 DPREGMMDLLNVPEPLRVYLLGSILDSDPPDHPRLRRLVTRAFAARRILGLRPGIERIAD 151 Query: 163 QLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGI 222 +L+ L + + V + + Y PLS V L GI Sbjct: 152 RLLAELPRREEEDGTVDLLEHFAY-----------------------PLSITVICELVGI 188 Query: 223 TASRNTLAKFLPGKRKQLR--EVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQIL 280 A+ + G +R +R S + +++RR AL D+L++++ Sbjct: 189 PATDLERWREWGGDLVSMRPERLRHSFPVMIDYCHRLIEQRRAALT------DDLLSELI 242 Query: 281 KAEEGAQDDEGLLDNF------VTFFIAGHETSANHLAFTVMELSRQPEIVARLQAE--- 331 +A++ DD G L + +T +AGHETSA+ + L P A L+ + Sbjct: 243 RAQD---DDGGRLSDIETVTMILTLVLAGHETSAHLIGNGTAALLTHPGQWALLRKDPAL 299 Query: 332 ----VDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPG 387 V E++ R+ + RL+Y ++ L+ L P A G D V++ Sbjct: 300 LPRAVHELM---RWCGSVHVARLRYATEDLE--LAGTPVARG-----------DAVQL-- 341 Query: 388 NTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEV 447 +L S R ++ DP + R G + + F G C+G A+ E Sbjct: 342 ---VLVSANFDPR---HYSDPDRLDITRHQEGQAE---NHVGFGHGIHYCLGATLARQEG 392 Query: 448 KVVMAKLLQ 456 +V +A+LL+ Sbjct: 393 EVALARLLE 401 >4WPZ-A nrPDB Length = 397 Score = 43.1 bits (100), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 54/231 (23%), Positives = 100/231 (43%), Gaps = 36/231 (15%) Query: 264 ALKRGEEVPAD-ILTQILKAEEGAQD--DEGLLDNFVTFFIAGHETSANHLAFTVMELSR 320 A+KR E PAD ++++++ +G + ++ + AGHET+AN ++ ++ L Sbjct: 193 AVKR--ENPADDLISELIAISDGDSTLTEREIIALSIGILSAGHETTANQISMFLVTLLH 250 Query: 321 QPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYP--PAWGTF-RLLEEE 377 PE E+D++ ++ + + + + E LR P G RL E Sbjct: 251 NPE-------ELDKLRDNR-----------EAIPKAVDELLRFVPLTTTGGIIPRLTTAE 292 Query: 378 TLIDGVRV-PGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRS 436 + G +V P +L + R FED N R + F G Sbjct: 293 VELSGGQVLPAGAVVLPAVATANRDPEVFEDGERLNVTR-------ENNPHLAFGAGIHH 345 Query: 437 CIGQQFAQMEVKVVMAKLLQRL-EFRL-VPGQRFGLQEQATLKPLDPVLCT 485 C+G Q A++E++ + +L R+ + RL VP L+ + ++ L+ + T Sbjct: 346 CLGAQLARIELQEALGAILDRMPQVRLAVPESELRLKSASIIRGLESLPIT 396 >3TYW-A nrPDB Length = 417 Score = 42.4 bits (98), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 49/221 (22%), Positives = 88/221 (39%), Gaps = 39/221 (17%) Query: 266 KRGEEVPADILTQILKAE--EGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPE 323 +R EE D++++++ G E LL AG ET+ + +A + + L +PE Sbjct: 211 ERREEPRDDLISKLVTDHLVPGNVTTEQLLSTLGITINAGRETTTSMIALSTLLLLDRPE 270 Query: 324 IVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGT-FRLLEEETLIDG 382 + A L+ + D + + E LR+ A R+ E+ + G Sbjct: 271 LPAELRKDPD------------------LMPAAVDELLRVLSVADSIPLRVAAEDIELSG 312 Query: 383 VRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQF 442 VP + ++ F+DP + R + F G C+GQ Sbjct: 313 RTVPADDGVIALLAGANHDPEQFDDPERVDFHRTD-------NHHVAFGYGVHQCVGQHL 365 Query: 443 AQMEVKVVMAKLLQRLEFRLVPGQR-----------FGLQE 472 A++E++V + LL+R+ + G+R FGL+E Sbjct: 366 ARLELEVALETLLRRVPTLRLAGERDQVVVKHDSATFGLEE 406 >5DQN-A nrPDB Length = 426 Score = 42.4 bits (98), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 42/190 (22%), Positives = 76/190 (40%), Gaps = 34/190 (17%) Query: 274 DILTQILKAEEGAQDDEGLLDNFVTFFI-----AGHETSANHLAFTVMELSRQPEIVARL 328 DI+T++++A+ D E L D+ FF+ AG+ET+ N + ++ ++ P Sbjct: 221 DIVTKLIEAD---IDGEKLSDDEFGFFVVMLAVAGNETTRNSITHGMIAFAQNP------ 271 Query: 329 QAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGN 388 D +L + + E +R P R E+ + GV++ Sbjct: 272 --------------DQWELYKKERPETAADEIVRWATPVSAFQRTALEDVELGGVQIKKG 317 Query: 389 TPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVK 448 ++ S + FEDP TFN R +P P + G CIG A+M + Sbjct: 318 QRVVMSYRSANFDEEVFEDPHTFNILR----SPNPHVGF--GGTGAHYCIGANLARMTIN 371 Query: 449 VVMAKLLQRL 458 ++ + + Sbjct: 372 LIFNAIADNM 381 >3A50-A nrPDB Length = 411 Score = 42.0 bits (97), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 58/234 (24%), Positives = 90/234 (38%), Gaps = 32/234 (13%) Query: 263 EALKRGEEVPADILTQILKAEEGAQDD----EGLLDNFVTFFIAGHETSANHLAFTVMEL 318 + L+R P D L L A D E L+ + IAGHET+ N + V+ L Sbjct: 193 DLLERKRTEPDDALLSSLLAVSDMDGDRLSQEELVAMAMLLLIAGHETTVNLIGNGVLAL 252 Query: 319 SRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPP-AWGTFRLLEEE 377 P+ +R L ED +S ++E LR P + R E+ Sbjct: 253 LTHPD---------------QRKLLAED---PSLISSAVEEFLRFDSPVSQAPIRFTAED 294 Query: 378 TLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSC 437 GV +P ++ R + +P + R G F F G C Sbjct: 295 VTYSGVTIPAGEMVMLGLAAANRDADWMPEPDRLDITRDASGG------VF-FGHGIHFC 347 Query: 438 IGQQFAQMEVKVVMAKLL-QRLEFRLVPGQRFGLQEQATL-KPLDPVLCTLRPR 489 +G Q A++E +V + +L R E L G + ++TL + L + T+ PR Sbjct: 348 LGAQLARLEGRVAIGRLFADRPELALAVGLDELVYRRSTLVRGLSRMPVTMGPR 401 >4RM4-A nrPDB Length = 396 Score = 41.6 bits (96), Expect = 0.001, Method: Compositional matrix adjust. Identities = 39/184 (21%), Positives = 76/184 (41%), Gaps = 27/184 (14%) Query: 274 DILTQILKAEEGAQ--DDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAE 331 DI++ +++AEE + E L+ +AG+ET+ N ++ + + P + L++ Sbjct: 209 DIISILVEAEETGEKLSGEELIPFCTLLLVAGNETTTNLISNAMYSILETPGVYEELRS- 267 Query: 332 VDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPL 391 + + Q ++E+LR PA R+ + +T I G + + Sbjct: 268 -----------------HPELMPQAVEEALRFRAPAPVLRRIAKRDTEIGGHLIKEGDMV 310 Query: 392 LFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVM 451 L R + F+ P F+ R P P + F G C+G A++E + + Sbjct: 311 LAFVASANRDEAKFDRPHMFDIRRH----PNP---HIAFGHGIHFCLGAPLARLEANIAL 363 Query: 452 AKLL 455 L+ Sbjct: 364 TSLI 367 >5HIW-A nrPDB Length = 398 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 31/106 (29%), Positives = 44/106 (41%), Gaps = 7/106 (6%) Query: 353 LSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFN 412 L Q ++ES R A G R +E E I G + T L S + + P TF+ Sbjct: 261 LPQAIEESTRWCSSAAGIVRFVEREATIGGETLAAGTILYLSLIARHYDEEIYPRPETFD 320 Query: 413 PDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRL 458 R G F G C+G A+ME +V ++ LL+R Sbjct: 321 IHRRPVG-------MLNFGGGLHYCVGAPLARMEARVGVSLLLERF 359 >4FB2-A nrPDB Length = 398 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 67/312 (21%), Positives = 116/312 (37%), Gaps = 60/312 (19%) Query: 162 EQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEG 221 EQL + D + + D T+ A +I A+ T++LLG + + Sbjct: 113 EQLRQSTNDLIDARIELGEGDAATWLANEIPARL-----TAILLGLPPEDGDTYRRWVWA 167 Query: 222 ITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILK 281 IT N E E L R + RR G ++ + ++ + Sbjct: 168 ITHVENP------------EEGAEIFAELVAHARTLIAERR--TNPGNDIMSRVIMSKID 213 Query: 282 AEEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRY 341 E ++DD L+ F + G + +A L+ L+ E+ RL Sbjct: 214 GESLSEDD--LIGFFTILLLGGIDNTARFLSSVFWRLAWDIELRRRL------------- 258 Query: 342 LDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRM 401 + + + + E LR Y PA + +E T+ D PG T +L+ + R Sbjct: 259 -----IAHPELIPNAVDELLRFYGPAMVGRLVTQEVTVGDITMKPGQTAMLWFP-IASRD 312 Query: 402 DTYFEDP----LTFNPDRFGPGAPKPRFTYFPFSLGH--RSCIGQQFAQMEVKVVMAKLL 455 + F+ P + P+R SLGH C+G ++E +V + + L Sbjct: 313 RSAFDSPDNIVIERTPNRH-------------LSLGHGIHRCLGAHLIRVEARVAITEFL 359 Query: 456 QRL-EFRLVPGQ 466 +R+ EF L P + Sbjct: 360 KRIPEFSLDPNK 371 >2RFC-A nrPDB Length = 343 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 31/162 (19%), Positives = 66/162 (40%), Gaps = 30/162 (18%) Query: 299 FFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLK 358 I G+ET+ N + + + P+I +D+ + ++ S ++ Sbjct: 185 LIIGGNETTTNLIGNMIRVIDENPDI-------IDDALKNR--------------SGFVE 223 Query: 359 ESLRLYPPA-WGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFG 417 E+LR Y P + R E++ I+ ++ ++ R +T+F++P F R Sbjct: 224 ETLRYYSPIQFLPHRFAAEDSYINNKKIKKGDQVIVYLGSANRDETFFDEPDLFKIGR-- 281 Query: 418 PGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLE 459 R + F +G C+G A++E + + +L + Sbjct: 282 ------REMHLAFGIGIHMCLGAPLARLEASIALNDILNHFK 317 >6FYJ-A nrPDB Length = 421 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 32/124 (25%), Positives = 54/124 (43%), Gaps = 8/124 (6%) Query: 348 GRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFED 407 G +Y ++E R YP L++++ G + T L Y +++ Sbjct: 275 GDKKYSQMFVQEVRRFYPFFPFVVALVKKDFTWKGYKFEEGTLTLLDLYGTNHDPEIWKN 334 Query: 408 PLTFNPDRFGPGAPKPRFTYFP-----FSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRL 462 P F+PDRF P F++ P + +GHR C G+ +KV + L R+++ Sbjct: 335 PDVFSPDRFAKWEGSP-FSFIPQGGGDYFMGHR-CAGEWVTIEVMKVSLDYLTNRMDYE- 391 Query: 463 VPGQ 466 VP Q Sbjct: 392 VPDQ 395 >5XNT-A nrPDB Length = 411 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 84/373 (22%), Positives = 145/373 (38%), Gaps = 69/373 (18%) Query: 126 VSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLT 185 ++E + K+R ++ AF+ SL + E A++L+E +M Sbjct: 88 ITEADPPEHRKRRSLLAAAFTPRSLQNWEPRIQEIADELIE---------------EMDE 132 Query: 186 YTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAK------FLPGKRKQ 239 T +DI+ A PL V L G+ + L K FLP +++ Sbjct: 133 ETEIDIVQSLA------------SPLPIIVMSDLMGVPSKDRLLFKKWVDILFLPFDKEK 180 Query: 240 LREVRESIRFLRQV-GRDWVQRRREALKRGEEVPA-DILTQILKAEEGAQ--DDEGLLDN 295 EV E L+QV +++ Q + + PA DI++ +LKAE + D+ ++ Sbjct: 181 QEEVNE----LKQVAAKEYYQYLYPIVVQKRLNPADDIISDLLKAEVDGEMFTDDEVVRT 236 Query: 296 FVTFFIAGHETSANHLAFTVME-LSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLS 354 + AG ET+++ LA + L E+ L +D V Sbjct: 237 TMLILGAGVETTSHLLANSFYSLLYDDKEVYQELHENLDLV------------------P 278 Query: 355 QVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPD 414 Q ++E LR R ++E+ + GV + ++ + FED T N Sbjct: 279 QAVEEMLRYRFNLIKLDRTVKEDNDLLGVELKEGENVVVWMSAANLDEEMFEDAFTLNIH 338 Query: 415 RFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLE-FRLVPGQRFGLQEQ 473 R P K + F G C+G A++E K+ + L++ + VP F L++ Sbjct: 339 R--PNNKK----HLTFGNGPHFCLGAPLARLEAKIALTTFLKKFKHIEAVPS--FQLEDN 390 Query: 474 ATLKPLDPVLCTL 486 T L +L Sbjct: 391 LTDSATGQTLTSL 403 >5L1U-A nrPDB Length = 401 Score = 40.0 bits (92), Expect = 0.003, Method: Compositional matrix adjust. Identities = 96/425 (22%), Positives = 160/425 (37%), Gaps = 60/425 (14%) Query: 69 KKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSE 128 +K GP+ RV + + +VT + V+ L + + S R F L + Sbjct: 28 QKEGPIARVGTAGEDAWLVTRYDEVRTLLADRRL-RLSNPNPQPSAKSAARAFMVALAAG 86 Query: 129 CNYER---WHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLT 185 ++E H Q R + + + + LM+T E + E+L+ A PV + +L+ Sbjct: 87 DDHETEPARHAQMRSLLIPRFSTRRLRLMKTRIE--HHVDELLDQLAASAPPVDLHRVLS 144 Query: 186 YTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRE 245 + ++ G+ PL A R ++ G Q + Sbjct: 145 FRLPTMVVCDLLGV----------PL------------ADRERFGQWARGTFDQ-SDNEH 181 Query: 246 SIRFLRQVGRDWVQRRREALKRGEEVPAD-ILTQILKAEEGAQDDEGL--LDNFVTFFIA 302 S +QV V E + R P D IL++++ ++GA D + L N V F Sbjct: 182 SANTFQQV----VDYMLELVARKRVEPGDDILSELIAEKDGALSDADIAHLGNAVLLF-- 235 Query: 303 GHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLR 362 G+ET+ + + L R P V R Q D + + LG S L Sbjct: 236 GYETTIVRIDLGTLLLLRNP--VQRAQLAEDPGLAPAAVEEILRLGVGGKGSNALI---- 289 Query: 363 LYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPK 422 P + + ET+I ++ + D F D F+ R + Sbjct: 290 ---PRYAHGDITVGETVIRT-----GDAVMLAIGAANYDDRAFPDGGLFDLTRV-----R 336 Query: 423 PRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRL-EFRL-VPGQRFGLQEQATLKPLD 480 PR ++ F G R CIG+ A++E+ V +L +RL + RL VP + QE D Sbjct: 337 PR-SHLAFGHGARHCIGRTLARIELTAVFERLFRRLPDLRLAVPEESLRWQEHRITGGFD 395 Query: 481 PVLCT 485 + T Sbjct: 396 EIPVT 400 >1F4U-A nrPDB Length = 368 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 43/197 (21%), Positives = 78/197 (39%), Gaps = 34/197 (17%) Query: 262 REALKRGEEVPADILTQILKAEEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQ 321 ++ L G EV + ++ L E L + IAG+ET+ N ++ +V++ +R Sbjct: 176 KDHLNSGTEVVSRVVNSNLSDIEK-------LGYIILLLIAGNETTTNLISNSVIDFTRF 228 Query: 322 PEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLID 381 + R++ E YL + ++E+LR PP T R +E + Sbjct: 229 -NLWQRIREE-------NLYL------------KAIEEALRYSPPVMRTVRKTKERVKLG 268 Query: 382 GVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQ 441 + + R + F D F PDR P P + F G C+G Sbjct: 269 DQTIEEGEYVRVWIASANRDEEVFHDGEKFIPDR----NPNP---HLSFGSGIHLCLGAP 321 Query: 442 FAQMEVKVVMAKLLQRL 458 A++E ++ + + +R Sbjct: 322 LARLEARIAIEEFSKRF 338 >1GWI-A nrPDB Length = 411 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 53/226 (23%), Positives = 83/226 (36%), Gaps = 46/226 (20%) Query: 242 EVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQ-ILKAEEGAQD--DEGLLDNFVT 298 EV ++ L + D V +R A P D LT +++A E D ++ Sbjct: 186 EVVATLTELASIMTDTVAAKRAA-------PGDDLTSALIQASENGDHLTDAEIVSTLQL 238 Query: 299 FFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLK 358 AGHET+ + + V+ LS PE +R L G ++ S V++ Sbjct: 239 MVAAGHETTISLIVNAVVNLSTHPE---------------QRALVLS--GEAEW-SAVVE 280 Query: 359 ESLRLYPPAWGTF-RLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFG 417 E+LR P R E+ + +P L+ S +GR + G Sbjct: 281 ETLRFSTPTSHVLIRFAAEDVPVGDRVIPAGDALIVSYGALGR-----------DERAHG 329 Query: 418 PGAPKPRFT------YFPFSLGHRSCIGQQFAQMEVKVVMAKLLQR 457 P A + T + F G C G ++ME V + L R Sbjct: 330 PTADRFDLTRTSGNRHISFGHGPHVCPGAALSRMEAGVALPALYAR 375 >5EX6-C nrPDB Length = 434 Score = 38.9 bits (89), Expect = 0.006, Method: Compositional matrix adjust. Identities = 49/201 (24%), Positives = 82/201 (40%), Gaps = 26/201 (12%) Query: 265 LKRGEEVPADILTQILKAEEGAQ-DDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPE 323 + R + P D L ++ AE G DE L V +AG + + + V+ L R PE Sbjct: 234 VARERKDPGDGLIGMVVAEHGDTVTDEELRGVCVQMMLAGDDNISGMIGLGVLALLRNPE 293 Query: 324 IVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGV 383 +A L+ +V ++R +D ++YL+ P A +E+ T+ D V Sbjct: 294 QIAALRGDVP---AAERAVDE----LIRYLT---------VPYAPTPRTAIEDSTVGDQV 337 Query: 384 RVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFA 443 G T V+ + T DP PD + + F G C+G A Sbjct: 338 IKAGET-------VLCSLPTANRDPALL-PDADRLDVTREAVPHVAFGHGVHHCLGAALA 389 Query: 444 QMEVKVVMAKLLQRL-EFRLV 463 ++E+++ L +R + RL Sbjct: 390 RLELRIAYTALWRRFPDLRLA 410 >3IVY-A nrPDB Length = 433 Score = 38.5 bits (88), Expect = 0.007, Method: Compositional matrix adjust. Identities = 52/206 (25%), Positives = 85/206 (41%), Gaps = 42/206 (20%) Query: 264 ALKRGEE---VPAD-ILTQILKAEEGAQDDEGLLDNFVTFFI-----AGHETSANHLAFT 314 A+K EE PAD I+TQ+++A+ D E L D+ FF+ AG+ET+ N + Sbjct: 224 AMKMAEEKAKNPADDIVTQLIQAD---IDGEKLSDDEFGFFVVMLAVAGNETTRNSITQG 280 Query: 315 VMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLL 374 +M + P+ Q E+ + + + D E +R P R Sbjct: 281 MMAFAEHPD-----QWELYKKVRPETAAD---------------EIVRWATPVTAFQRTA 320 Query: 375 EEETLIDGVRV-PGNTPLLFSTYVMGRMD-TYFEDPLTFNPDRFGPGAPKPRFTYFPFSL 432 + + GV++ G ++F Y D F+DP TFN R P P + Sbjct: 321 LRDYELSGVQIKKGQRVVMF--YRSANFDEEVFQDPFTFNILR----NPNPHVGF--GGT 372 Query: 433 GHRSCIGQQFAQMEVKVVMAKLLQRL 458 G CIG A+M + ++ + + Sbjct: 373 GAHYCIGANLARMTINLIFNAVADHM 398 >4XE3-A nrPDB Length = 407 Score = 37.7 bits (86), Expect = 0.010, Method: Compositional matrix adjust. Identities = 40/165 (24%), Positives = 66/165 (40%), Gaps = 31/165 (18%) Query: 297 VTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQV 356 V+ IAGHETS N + V L + KRY + + Sbjct: 239 VSLLIAGHETSVNQITNLVHLL----------------LTERKRYESL--VADPALVPAA 280 Query: 357 LKESLRLYP-PAWGTF-RLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFE--DPLTFN 412 ++E LR P + G+F R+ E+ + V V P + R + F+ D L F+ Sbjct: 281 VEEMLRYTPLVSAGSFVRVATEDVELSTVTVRAGEPCVVHFASANRDEEVFDHADELDFH 340 Query: 413 PDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQR 457 + R + F G CIG Q ++E++ ++ L++R Sbjct: 341 ---------RERNPHIAFGHGAHHCIGAQLGRLELQEALSALVRR 376 >5D3U-A nrPDB Length = 427 Score = 37.4 bits (85), Expect = 0.015, Method: Compositional matrix adjust. Identities = 73/369 (19%), Positives = 125/369 (33%), Gaps = 78/369 (21%) Query: 115 VFGERLFGQGLVSECNYERWHKQ-------------RRVIDLAFSRSSLVSLMETFNEKA 161 V + GQ L + + RW K RR + F+R++ + + A Sbjct: 84 VLAAKFPGQPLPPDNIFHRWTKNVVMYTDPPLHDALRRSVRAGFTRAAHQHYDQVLQKVA 143 Query: 162 EQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLM--- 218 LV + A A T +D + L A+ P+ AV Sbjct: 144 HDLVASIPAGA--------------TEIDAVPA----------LAAELPVRSAVHAFGVP 179 Query: 219 ---LEGITASRNTLAKFLPGKRKQ---LREVRESIRFLRQVGRDWVQRRREALKRGEEVP 272 L + NT+ + G + Q + E + L + +Q RG+ +P Sbjct: 180 EEDLGFLIPRVNTIMTYFSGPKDQPVTQEIILEKLTDLHTYASELLQG-----MRGKVLP 234 Query: 273 ADILTQILKAEEGAQDD--EGLLDNFVTFFIAGHE-TSANHLAFTVMELSRQPEIVARLQ 329 ++ ++ A++G + E + FIA T+ L+ + +R P V R Sbjct: 235 DTVIARLAAAQDGLTETTPEQTVHQLALVFIALFAPTTPGSLSSGTLAFARNPRQVERFL 294 Query: 330 AEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNT 389 A+ V E LR T+R+ ++ + GVR+ Sbjct: 295 ADQACV------------------DNTANEVLRYNASNQFTWRVAAKDVEMGGVRIEAGQ 336 Query: 390 PLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKV 449 L R FE P F+ DR P + + + F G +C+ Q +++K Sbjct: 337 TLALFLGSANRDANMFERPNDFDLDR--PNSAR----HLSFGQGVHACLAAQLISLQLKW 390 Query: 450 VMAKLLQRL 458 LL R Sbjct: 391 FYVALLNRF 399 >3NV6-A nrPDB Length = 452 Score = 36.2 bits (82), Expect = 0.034, Method: Compositional matrix adjust. Identities = 38/163 (23%), Positives = 67/163 (41%), Gaps = 27/163 (16%) Query: 305 ETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLY 364 +T N L+F ++ L+R PE+VA L+++ L + +E R + Sbjct: 293 DTVVNFLSFFMIHLARHPELVAELRSDP------------------LKLMRGAEEMFRRF 334 Query: 365 PPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPR 424 P R++ ++ GV + +L T + G D +P + R Sbjct: 335 -PVVSEARMVAKDQEYKGVFLKRGDMILLPTALHGLDDAANPEPWKLDFSRRS------- 386 Query: 425 FTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRL-EFRLVPGQ 466 ++ F G C G A+MEV V + + L+R+ EF G+ Sbjct: 387 ISHSTFGGGPHRCAGMHLARMEVIVTLEEWLKRIPEFSFKEGE 429 >3A1L-A nrPDB Length = 425 Score = 36.2 bits (82), Expect = 0.038, Method: Compositional matrix adjust. Identities = 34/167 (20%), Positives = 60/167 (35%), Gaps = 25/167 (14%) Query: 290 EGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGR 349 +G++ V AGHET+ N LA V+ L +++ L+ + + Sbjct: 242 DGIVGTCVHLLTAGHETTTNFLAKAVLTLRAHRDVLDELRTTPESTPAA----------- 290 Query: 350 LQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPL 409 ++E +R PP R E+ + +P + ++ R F DP Sbjct: 291 -------VEELMRYDPPVQAVTRWAYEDIRLGDHDIPRGSRVVALLGSANRDPARFPDPD 343 Query: 410 TFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQ 456 + R F LG C+G A+ E ++ + LL Sbjct: 344 VLDVHRAAE-------RQVGFGLGIHYCLGATLARAEAEIGLRALLD 383 >5DE9-A nrPDB Length = 410 Score = 35.4 bits (80), Expect = 0.052, Method: Compositional matrix adjust. Identities = 43/179 (24%), Positives = 69/179 (38%), Gaps = 33/179 (18%) Query: 297 VTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQV 356 V I G + N + LSR PE+ RL++E + + Sbjct: 237 VLLQIGGEAVTNNSGQMFHLLLSR-PELAERLRSEP------------------EIRPRA 277 Query: 357 LKESLRLYP--PAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPD 414 + E LR P A G R+ E+ I GVR+ + S R F DP + + Sbjct: 278 IDELLRWIPHRNAVGLSRIALEDVEIKGVRIRAGDAVYVSYLAANRDPEVFPDPDRIDFE 337 Query: 415 RFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQ 473 R +P P + F G C G A++E ++++ +L R VPG + + + Sbjct: 338 R----SPNPHVS---FGFGPHYCPGGMLARLESELLVDAVLDR-----VPGLKLAVAPE 384 >6A7I-A nrPDB Length = 411 Score = 35.4 bits (80), Expect = 0.055, Method: Compositional matrix adjust. Identities = 45/195 (23%), Positives = 74/195 (37%), Gaps = 38/195 (19%) Query: 272 PADILTQILKAEEGAQD---DEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARL 328 P D LT L A D DE +++ AGHET+ + + V L PE Sbjct: 207 PGDDLTSALIAASENGDHLTDEEIVNTLQLIIAAGHETTISLIVNVVEALQTHPE----- 261 Query: 329 QAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTF-RLLEEETLIDGVRVPG 387 K+ L+ G + + V++E+LR P R E+ + +P Sbjct: 262 --------QRKKVLN----GEIGW-DGVIEETLRWNTPTSHVLIRFATEDIEVGDKILPK 308 Query: 388 NTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFP-----FSLGHRSCIGQQF 442 L+ S +GR + +++GP A + T P F G C G Sbjct: 309 GEGLIISFGALGR-----------DEEQYGPTAGEFDATRTPNRHIAFGHGPHVCPGAAL 357 Query: 443 AQMEVKVVMAKLLQR 457 +++E + + L +R Sbjct: 358 SRLEAGIALPALYER 372 >3BUJ-A nrPDB Length = 397 Score = 35.0 bits (79), Expect = 0.068, Method: Compositional matrix adjust. Identities = 40/174 (22%), Positives = 69/174 (39%), Gaps = 26/174 (14%) Query: 274 DILTQILKAEE-GAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEV 332 D+L +L A + G ++ VTF GHET A+ + V+ L P+ + L+ Sbjct: 204 DLLALMLDAHDRGLMSRNEIVSTVVTFIFTGHETVASQVGNAVLSLLAHPDQLDLLRRRP 263 Query: 333 DEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLL 392 D L+Q ++E LR P R L+ + + G R+ + ++ Sbjct: 264 D------------------LLAQAVEECLRYDPSVQSNTRQLDVDVELRGRRLRRDDVVV 305 Query: 393 FSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQME 446 R ++ P F+ +R P P + F G R C+G A+ + Sbjct: 306 VLAGAANRDPRRYDRPDDFDIER----DPVPSMS---FGAGMRYCLGSYLARTQ 352 >6A7J-A nrPDB Length = 411 Score = 34.7 bits (78), Expect = 0.095, Method: Compositional matrix adjust. Identities = 47/195 (24%), Positives = 75/195 (38%), Gaps = 38/195 (19%) Query: 272 PADILTQILKA--EEGAQ-DDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARL 328 P D LT L A E+G DE +L+ AGHET+ + + V L+ PE Sbjct: 207 PGDDLTSALIAASEDGDHLTDEEILNTLQLIIAAGHETTISLIVNVVEALAIHPE----- 261 Query: 329 QAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTF-RLLEEETLIDGVRVPG 387 K+ L G + + V++E+LR P R E+ + +P Sbjct: 262 --------QRKKVLS----GEIPW-EGVIEETLRWNTPTSHVLIRFATEDIEVGDKVLPK 308 Query: 388 NTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFP-----FSLGHRSCIGQQF 442 L+ S +GR + +++GP A T P F G C G Sbjct: 309 GEGLVVSFGALGR-----------DEEQYGPTAGDFDATRTPNRHIAFGHGPHVCPGAAL 357 Query: 443 AQMEVKVVMAKLLQR 457 +++E + + L +R Sbjct: 358 SRLEAGIALPALYER 372 >1Q5D-A nrPDB Length = 419 Score = 34.3 bits (77), Expect = 0.12, Method: Compositional matrix adjust. Identities = 52/221 (23%), Positives = 87/221 (39%), Gaps = 47/221 (21%) Query: 259 QRRREALKRGEEVPADILTQILKAE-EGAQDDEGLLDNFVTFFIA-GHETSANHLAFTVM 316 +RRR L+ D+LT +L+AE +G++ L V IA G +T+ +AF V+ Sbjct: 215 ERRRNPLEN------DVLTMLLQAEADGSRLSTKELVALVGAIIAAGTDTTIYLIAFAVL 268 Query: 317 ELSRQPEIVARLQAE-------VDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWG 369 L R PE + ++AE +DEV L F+++ R+ G Sbjct: 269 NLLRSPEALELVKAEPGLMRNALDEV------LRFDNILRI------------------G 304 Query: 370 TFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFP 429 T R ++ G + + R T F P F+ R + Sbjct: 305 TVRFARQDLEYCGASIKKGEMVFLLIPSALRDGTVFSRPDVFDVRRDTSAS-------LA 357 Query: 430 FSLGHRSCIGQQFAQMEVKVVMAKLLQRL-EFRLVPGQRFG 469 + G C G A++E ++ + + +R E +L FG Sbjct: 358 YGRGPHVCPGVSLARLEAEIAVGTIFRRFPEMKLKETPVFG 398 >6HQG-A nrPDB Length = 425 Score = 34.3 bits (77), Expect = 0.13, Method: Compositional matrix adjust. Identities = 36/187 (19%), Positives = 80/187 (42%), Gaps = 27/187 (14%) Query: 274 DILTQILKAEEGAQDDE-GLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEV 332 D+++ + E D L N + + G++T+ N ++ +V+ L + P+ +L+ Sbjct: 233 DLISMLAHGESTKNMDRMEYLGNLILLIVGGNDTTRNTISGSVLALHQNPDQDRKLR--- 289 Query: 333 DEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRV-PGNTPL 391 E+ G + ++ E++R P R + + + G + G+ Sbjct: 290 ------------ENPG---LIPAMVSETIRWQTPLAYMRRRAKRDFELGGKTIREGDKVA 334 Query: 392 LFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVM 451 ++ YV G D D P+ + P+ R + F G C+G + A++++K++ Sbjct: 335 MW--YVSGNRDEEVID----RPNDYWIERPRVR-QHLSFGFGVHRCVGNRLAELQLKIIW 387 Query: 452 AKLLQRL 458 ++L R Sbjct: 388 EEILARF 394 >2IAG-A nrPDB Length = 482 Score = 33.1 bits (74), Expect = 0.25, Method: Compositional matrix adjust. Identities = 39/167 (23%), Positives = 67/167 (40%), Gaps = 23/167 (13%) Query: 320 RQPEIVARLQAEVDEV-------IGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFR 372 + PE +A ++ E++ + + L + L L VL ESLRL + T Sbjct: 279 KNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITRE 338 Query: 373 LLEEETL--IDGVRVP---GNTPLLFSTYVMGRMDTYFEDPLTFNPDRF-GPGAPKPRFT 426 ++ + + DG G+ LLF R + DP F +RF P + + Sbjct: 339 VVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDF 398 Query: 427 Y----------FPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLV 463 Y P+ GH C+G+ +A +K + +L L+ L+ Sbjct: 399 YKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELI 445 >3U0R-A nrPDB Length = 507 Score = 32.3 bits (72), Expect = 0.44, Method: Compositional matrix adjust. Identities = 44/168 (26%), Positives = 74/168 (44%), Gaps = 27/168 (16%) Query: 205 LGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRES-IRFLRQVGRDW-VQRRR 262 +G K Q + ++G T + A+F+P K E+ +S I + D V RR Sbjct: 24 VGQHKDAYQVILDGVKGGTKEKRLAAQFIPKFFKHFPELADSAINAQLDLCEDEDVSIRR 83 Query: 263 EALKR------GEEVP--ADILTQILKAEEGAQ--------------DDEGLLDNFVTFF 300 +A+K GE +P ADILTQ+L+ ++ A+ D +G L + Sbjct: 84 QAIKELPQFATGENLPRVADILTQLLQTDDSAEFNLVNNALLSIFKMDAKGTLGGLFSQI 143 Query: 301 IAGHE-TSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDL 347 + G + + F +L P+ V L EV+E+I ++ ED+ Sbjct: 144 LQGEDIVRERAIKFLSTKLKTLPDEV--LTKEVEELILTESKKVLEDV 189 >3OFT-A nrPDB Length = 396 Score = 31.6 bits (70), Expect = 0.80, Method: Compositional matrix adjust. Identities = 49/197 (24%), Positives = 71/197 (36%), Gaps = 33/197 (16%) Query: 298 TFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVL 357 G +T A + + L+R PE RL E R + Sbjct: 230 NLLFGGLDTVAAMIGMVALHLARHPED-QRLLRE-----------------RPDLIPAAA 271 Query: 358 KESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMD-TYFEDPLTFNPDRF 416 E +R YP R + DGV + L++ V+ +D FE P RF Sbjct: 272 DELMRRYPTV-AVSRNAVADVDADGVTIRKGD-LVYLPSVLHNLDPASFEAPEEV---RF 326 Query: 417 GPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRL-EFRLVPGQRFGLQEQAT 475 G R T +G C+G A+MEV V + + L + EF L P + T Sbjct: 327 DRGLAPIRHTTM--GVGAHRCVGAGLARMEVIVFLREWLGGMPEFALAP------DKAVT 378 Query: 476 LKPLDPVLCTLRPRGWQ 492 +K + CT P W+ Sbjct: 379 MKGGNVGACTALPLVWR 395 >6G71-A nrPDB Length = 405 Score = 31.2 bits (69), Expect = 1.0, Method: Compositional matrix adjust. Identities = 30/113 (26%), Positives = 45/113 (39%), Gaps = 9/113 (7%) Query: 356 VLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDR 415 V +ES+R P R +T +DG +P L R + + DP F+ +R Sbjct: 272 VFEESIRWVAPIGMVPRQTVVDTELDGYFIPRGAKLGLCILSANRDRSVWSDPDRFDIER 331 Query: 416 FGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEV-KVVMAKLLQRLE-FRLVPGQ 466 + F G C+G A+ +V V + L RL+ RL P Q Sbjct: 332 GSE-------AHLAFGKGVHVCLGAWAARSQVADVGLPALFSRLKGLRLDPNQ 377 >4TX3-A nrPDB Length = 404 Score = 30.8 bits (68), Expect = 1.3, Method: Compositional matrix adjust. Identities = 36/134 (26%), Positives = 55/134 (41%), Gaps = 12/134 (8%) Query: 217 LMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADIL 276 ++ E I R+ A FL + L + S R G + + + R + P D Sbjct: 157 VLCELIGVPRDDQAMFLQLCHRHL-DASLSARKRAAAGEAFARYLVAMMARERKDPGDGF 215 Query: 277 TQILKAEEGAQ-DDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAE---- 331 + AE G DE L V +AG + + + V+ L R PE +A L+ + Sbjct: 216 IGSIVAEHGDTITDEELRGVCVQLMLAGDDNVSGMIGLGVLALLRHPEQIAALRGDDQSA 275 Query: 332 ---VDEVIGSKRYL 342 VDE+I RYL Sbjct: 276 DRAVDELI---RYL 286 >3A3K-A nrPDB Length = 435 Score = 30.8 bits (68), Expect = 1.6, Method: Compositional matrix adjust. Identities = 38/167 (22%), Positives = 73/167 (43%), Gaps = 7/167 (4%) Query: 24 HRARSRYEHIPGPPRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKT 83 H+A Y G RP F + ++ + V F++ + P + V K Sbjct: 148 HQALVLYADRLGDDRPCFFIVEGLYMRVRERLNITVNHQEFVEGDPDHYPKLLRAVRRKG 207 Query: 84 SVI--VTSPESVKKFLM---STKYNKDSKMYRALQTVFGERL-FGQGLVSECNYERWHKQ 137 VI +SP++ + ++ + + ++ L VFG+ L QGLV + +ER Q Sbjct: 208 RVIYICSSPDAFRNLMLLALNAGLTGEDYVFFHLD-VFGQSLKSAQGLVPQKPWERGDGQ 266 Query: 138 RRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDML 184 R AF + +++ E N + + ++ L+ AD + +++D L Sbjct: 267 DRSARQAFQAAKIITYKEPDNPEYLEFLKQLKLLADKKFNFTVEDGL 313 >6FSH-A nrPDB Length = 398 Score = 30.4 bits (67), Expect = 1.6, Method: Compositional matrix adjust. Identities = 26/86 (30%), Positives = 38/86 (44%), Gaps = 11/86 (12%) Query: 265 LKRGEEVPADILTQILKAEEGAQ-DDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPE 323 + R + P D + AE G DE L V +AG + + + V+ L R PE Sbjct: 198 IARERKDPGDGFIGSIVAEHGDTITDEELRGVCVQLMLAGDDNVSGMIGLGVLALLRHPE 257 Query: 324 IVARLQAE-------VDEVIGSKRYL 342 +A L+ + VDE+I RYL Sbjct: 258 QIAALRGDDQSADRAVDELI---RYL 280 >1LTX-R nrPDB Length = 650 Score = 30.0 bits (66), Expect = 2.2, Method: Compositional matrix adjust. Identities = 19/71 (26%), Positives = 35/71 (49%) Query: 103 NKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAE 162 +K+S+ +A+ FG+R+ + + E +Y + RV SR+ L++ A+ Sbjct: 407 DKESRKCKAVIDQFGQRIISKHFIIEDSYLSENTCSRVQYRQISRAVLITDGSVLKTDAD 466 Query: 163 QLVEILEAKAD 173 Q V IL A+ Sbjct: 467 QQVSILTVPAE 477 >6NI0-A nrPDB Length = 249 Score = 28.9 bits (63), Expect = 5.1, Method: Compositional matrix adjust. Identities = 24/68 (35%), Positives = 33/68 (48%), Gaps = 3/68 (4%) Query: 336 IGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWG-TFRLLEEETLIDGVRVPGNTPLLFS 394 IGS L L +L++LS++L L + P A T R++E TL DG V G T + Sbjct: 130 IGSS--LQISPLEQLRFLSKMLNRKLPVSPNAVDMTERIVEATTLADGTVVHGKTGAAYP 187 Query: 395 TYVMGRMD 402 G D Sbjct: 188 LLADGTRD 195 >3UX8-A nrPDB Length = 670 Score = 28.1 bits (61), Expect = 8.3, Method: Compositional matrix adjust. Identities = 17/42 (40%), Positives = 24/42 (57%), Gaps = 2/42 (4%) Query: 240 LREVRESIRFLRQVGRDWVQRRREA--LKRGEEVPADILTQI 279 LRE+R+ + FL+ VG D++ R A L GE + TQI Sbjct: 176 LREIRDRLGFLQNVGLDYLTLSRSAGTLSGGEAQRIRLATQI 217 >2R6F-A nrPDB Length = 972 Score = 28.1 bits (61), Expect = 9.2, Method: Compositional matrix adjust. Identities = 17/42 (40%), Positives = 24/42 (57%), Gaps = 2/42 (4%) Query: 240 LREVRESIRFLRQVGRDWVQRRREA--LKRGEEVPADILTQI 279 LRE+R+ + FL+ VG D++ R A L GE + TQI Sbjct: 478 LREIRDRLGFLQNVGLDYLTLSRSAGTLSGGEAQRIRLATQI 519 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 3MDV-A nrPDB 510 e-145 2NNH-A nrPDB 381 e-106 5W0C-A nrPDB 365 e-101 1N6B-A nrPDB 359 1e-99 4GQS-A nrPDB 358 4e-99 6DA2-A nrPDB 348 3e-96 6B82-A nrPDB 345 2e-95 5VEU-A nrPDB 344 4e-95 5E58-A nrPDB 340 5e-94 4H1N-A nrPDB 339 2e-93 5E0E-A nrPDB 333 1e-91 3IBD-A nrPDB 332 3e-91 3E6I-A nrPDB 332 3e-91 2PG7-A nrPDB 325 2e-89 3MZS-A nrPDB 318 3e-87 3N9Z-A nrPDB 318 4e-87 4R20-A nrPDB 317 9e-87 5UYS-A nrPDB 313 1e-85 4R1Z-A nrPDB 312 2e-85 4WMZ-A nrPDB 312 2e-85 5JLC-A nrPDB 310 1e-84 3JUS-A nrPDB 307 1e-83 5YLW-A nrPDB 307 1e-83 6DWN-A nrPDB 304 5e-83 3L4D-A nrPDB 303 8e-83 3K9V-A nrPDB 303 1e-82 3QZ1-A nrPDB 302 2e-82 4KPA-A nrPDB 302 3e-82 2WX2-A nrPDB 300 9e-82 5VBU-A nrPDB 299 2e-81 2X2N-A nrPDB 295 4e-80 3DL9-A nrPDB 293 1e-79 6AYB-A nrPDB 292 2e-79 2HI4-A nrPDB 291 5e-79 5FSA-A nrPDB 289 2e-78 6CR2-A nrPDB 285 2e-77 3EL3-A nrPDB 284 6e-77 6IQ5-A nrPDB 282 3e-76 6C94-A nrPDB 281 6e-76 2VE3-A nrPDB 280 1e-75 3TBG-A nrPDB 269 2e-72 3S79-A nrPDB 263 1e-70 4ZGX-A nrPDB 254 8e-68 6M7X-A nrPDB 246 1e-65 3EJB-B nrPDB 246 1e-65 5VWS-A nrPDB 241 4e-64 5NWS-A nrPDB 240 1e-63 2W0A-A nrPDB 237 7e-63 2Y5N-A nrPDB 237 9e-63 5OFQ-A nrPDB 235 3e-62 5L94-A nrPDB 235 3e-62 4UBS-A nrPDB 227 7e-60 2VZM-A nrPDB 227 1e-59 5CJE-A nrPDB 225 3e-59 4GGV-A nrPDB 222 3e-58 4RM4-A nrPDB 221 4e-58 6GMF-A nrPDB 220 9e-58 5IT1-A nrPDB 218 4e-57 3A50-A nrPDB 216 1e-56 2Z36-A nrPDB 216 2e-56 2ZBZ-A nrPDB 215 4e-56 4Z5P-A nrPDB 214 5e-56 3ABA-A nrPDB 214 6e-56 1ODO-A nrPDB 214 9e-56 3WVS-A nrPDB 213 2e-55 2WIO-A nrPDB 210 1e-54 1EHE-A nrPDB 207 1e-53 5Y1I-A nrPDB 206 2e-53 3ABB-A nrPDB 206 3e-53 3R9C-A nrPDB 204 5e-53 5FOI-A nrPDB 203 2e-52 4MM0-A nrPDB 201 6e-52 4WPZ-A nrPDB 201 7e-52 4OQS-A nrPDB 201 7e-52 5XW2-A nrPDB 201 8e-52 3TYW-A nrPDB 201 8e-52 5YSW-A nrPDB 200 9e-52 4OQR-A nrPDB 200 9e-52 6GK6-A nrPDB 198 5e-51 6B11-A nrPDB 195 4e-50 4TRI-A nrPDB 194 6e-50 1WIY-A nrPDB 193 2e-49 5Z9I-A nrPDB 193 2e-49 3P3Z-A nrPDB 189 2e-48 2WM5-A nrPDB 188 4e-48 1CPT-A nrPDB 187 1e-47 3MGX-A nrPDB 186 2e-47 6GII-A nrPDB 185 4e-47 6CVC-A nrPDB 182 2e-46 3NC3-A nrPDB 181 4e-46 3RWL-A nrPDB 178 4e-45 5LIV-A nrPDB 176 2e-44 6DCD-A nrPDB 176 2e-44 2NZA-A nrPDB 175 3e-44 3SN5-A nrPDB 175 4e-44 6F88-A nrPDB 175 4e-44 5DQN-A nrPDB 174 8e-44 5HDI-A nrPDB 167 6e-42 2RFC-A nrPDB 167 7e-42 4FB2-A nrPDB 166 2e-41 3TKT-A nrPDB 161 5e-40 5HIW-A nrPDB 161 8e-40 6FYJ-A nrPDB 148 6e-36 2WIY-A nrPDB 144 8e-35 5KYO-A nrPDB 143 1e-34 4C9K-A nrPDB 129 2e-30 Sequences not found previously or not previously below threshold: 1Z8P-A nrPDB 210 1e-54 5XNT-A nrPDB 209 3e-54 4YT3-A nrPDB 206 1e-53 5XJN-A nrPDB 202 3e-52 4YZR-A nrPDB 202 4e-52 5GWE-A nrPDB 202 4e-52 4JBT-A nrPDB 199 3e-51 4Z5Q-A nrPDB 189 2e-48 5EX6-C nrPDB 184 7e-47 5LIE-A nrPDB 183 1e-46 2XKR-A nrPDB 181 5e-46 6A7J-A nrPDB 181 5e-46 1GWI-A nrPDB 181 6e-46 6A7I-A nrPDB 179 2e-45 4XE3-A nrPDB 178 4e-45 5L1U-A nrPDB 178 4e-45 6M7L-A nrPDB 176 2e-44 1UED-A nrPDB 175 3e-44 5DE9-A nrPDB 173 1e-43 2FR7-A nrPDB 173 1e-43 6HQG-A nrPDB 172 3e-43 6FSH-A nrPDB 171 7e-43 6F0B-A nrPDB 170 1e-42 1F4U-A nrPDB 170 1e-42 4TX3-A nrPDB 170 1e-42 1LG9-A nrPDB 169 2e-42 5FYF-A nrPDB 168 4e-42 1Q5D-A nrPDB 167 1e-41 6HQW-A nrPDB 167 1e-41 4DO1-A nrPDB 166 2e-41 3A1L-A nrPDB 164 5e-41 1UE8-A nrPDB 162 3e-40 5H1Z-A nrPDB 161 7e-40 2UUQ-A nrPDB 159 2e-39 2X9P-A nrPDB 158 5e-39 4PWV-A nrPDB 157 8e-39 3BUJ-A nrPDB 156 2e-38 3IVY-A nrPDB 156 2e-38 3OFT-A nrPDB 149 2e-36 5HH3-A nrPDB 149 3e-36 3OO3-A nrPDB 147 1e-35 6BLD-A nrPDB 147 1e-35 5D3U-A nrPDB 146 3e-35 6G5O-A nrPDB 145 4e-35 6HQD-A nrPDB 145 6e-35 3WEC-A nrPDB 144 1e-34 5EX8-A nrPDB 137 9e-33 5OMS-A nrPDB 133 1e-31 6G71-A nrPDB 131 7e-31 3NV6-A nrPDB 130 1e-30 2QBO-A nrPDB 129 4e-30 5M0P-A nrPDB 125 4e-29 2ZQJ-A nrPDB 124 8e-29 2IJ7-A nrPDB 122 3e-28 5YHJ-A nrPDB 111 7e-25 3AWQ-A nrPDB 110 2e-24 2IAG-A nrPDB 105 3e-23 3B98-A nrPDB 105 5e-23 2RCM-A nrPDB 97 2e-20 3DBM-A nrPDB 92 7e-19 2YJN-B nrPDB 61 1e-09 3A4L-A nrPDB 34 0.13 6H7W-B nrPDB 32 0.59 4DJD-D nrPDB 31 1.5 2WNW-A nrPDB 30 2.7 5OWU-A nrPDB 29 4.4 1ZC1-A nrPDB 29 4.5 5Y77-A nrPDB 29 5.1 3WWM-A nrPDB 29 5.9 2F3T-A nrPDB 29 6.3 3RP9-A nrPDB 29 6.9 5ZJI-1 nrPDB 29 6.9 >3MDV-A nrPDB Length = 456 Score = 510 bits (1312), Expect = e-145, Method: Composition-based stats. Identities = 450/450 (100%), Positives = 450/450 (100%) Query: 51 KKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYR 110 KKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYR Sbjct: 3 KKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYR 62 Query: 111 ALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEA 170 ALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEA Sbjct: 63 ALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEA 122 Query: 171 KADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLA 230 KADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLA Sbjct: 123 KADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLA 182 Query: 231 KFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDE 290 KFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDE Sbjct: 183 KFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDE 242 Query: 291 GLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRL 350 GLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRL Sbjct: 243 GLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRL 302 Query: 351 QYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLT 410 QYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLT Sbjct: 303 QYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLT 362 Query: 411 FNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGL 470 FNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGL Sbjct: 363 FNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGL 422 Query: 471 QEQATLKPLDPVLCTLRPRGWQPAPPPPPC 500 QEQATLKPLDPVLCTLRPRGWQPAPPPPPC Sbjct: 423 QEQATLKPLDPVLCTLRPRGWQPAPPPPPC 452 >2NNH-A nrPDB Length = 476 Score = 381 bits (978), Expect = e-106, Method: Composition-based stats. Identities = 99/461 (21%), Positives = 179/461 (38%), Gaps = 30/461 (6%) Query: 23 VHRARSRYEHIPGPPRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHK 82 + + S +P P P LP ++ + + F +++K YGPV V Sbjct: 1 MAKKTSSKGKLPPGPTP------LPIIGNMLQIDVKDICKSFTNFSKVYGPVFTVYFGMN 54 Query: 83 TSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVID 142 V+ E+VK+ L+ + R + G G++S N +RW + RR Sbjct: 55 PIVVFHGYEAVKEALIDNG---EEFSGRGNSPISQRITKGLGIIS-SNGKRWKEIRRFSL 110 Query: 143 LAFSRSSL--VSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKA----A 196 + S+ + E+A LVE L + +P +L +++ Sbjct: 111 TTLRNFGMGKRSIEDRVQEEAHCLVEEL--RKTKASPCDPTFILGCAPCNVICSVVFQKR 168 Query: 197 FGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRD 256 F + L K ++ +++ N + +V +++ R R+ Sbjct: 169 FDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYIRE 228 Query: 257 WVQRRREALKRGEEVPADILTQILKAEEGAQDD-------EGLLDNFVTFFIAGHETSAN 309 V+ + +L P D + L E +D+ E L+ F+AG ET++ Sbjct: 229 KVKEHQASLDVNN--PRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTST 286 Query: 310 HLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAW- 368 L + ++ L + PE+ A++Q E+D VIG R +D + Y V+ E R Sbjct: 287 TLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPT 346 Query: 369 GTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFG--PGAPKPRFT 426 G + +T +P T ++ + D F +P F+P F G K Sbjct: 347 GVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDY 406 Query: 427 YFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQR 467 + PFS G R C G+ A+ME+ + + +LQ + V + Sbjct: 407 FMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLK 447 >5W0C-A nrPDB Length = 477 Score = 365 bits (938), Expect = e-101, Method: Composition-based stats. Identities = 98/477 (20%), Positives = 187/477 (39%), Gaps = 41/477 (8%) Query: 36 PPRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKK 95 PP P+ LP ++G + + + +K YGPV + K V++ E+VK+ Sbjct: 13 PPGPT----PLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKE 68 Query: 96 FLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSL--VSL 153 L+ + R + + G G+V N ++W + RR + + S+ Sbjct: 69 ALIDLG---EEFSGRGIFPLAERANRGFGIVF-SNGKKWKEIRRFSLMTLRNFGMGKRSI 124 Query: 154 METFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKA----AFGMETSMLLGAQK 209 + E+A LVE L + +P +L +++ F + L + Sbjct: 125 EDRVQEEARCLVEEL--RKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLME 182 Query: 210 PLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGE 269 L++ +K++ N + + ++ +++ F++ + V+ +E++ Sbjct: 183 KLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNN 242 Query: 270 EVPADILTQILKAEEGAQDD-------EGLLDNFVTFFIAGHETSANHLAFTVMELSRQP 322 P D + L E + + E L + V F AG ET++ L + ++ L + P Sbjct: 243 --PQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHP 300 Query: 323 EIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAW-GTFRLLEEETLID 381 E+ A++Q E++ VIG R +D + Y V+ E R + + Sbjct: 301 EVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFR 360 Query: 382 GVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGP--GAPKPRFTYFPFSLGHRSCIG 439 +P T +L S + + F +P F+P F G K + PFS G R C+G Sbjct: 361 NYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVG 420 Query: 440 QQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPVLCTLRPRGWQPAPP 496 + A ME+ + + +LQ + +L + T G+ PP Sbjct: 421 EALAGMELFLFLTSILQNFNLK-------------SLVDPKNLDTTPVVNGFASVPP 464 >1N6B-A nrPDB Length = 473 Score = 359 bits (922), Expect = 1e-99, Method: Composition-based stats. Identities = 100/487 (20%), Positives = 196/487 (40%), Gaps = 40/487 (8%) Query: 23 VHRARSRYEHIPGPPRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHK 82 + + S +P P P ++G++ ++ + + +++ YGPV V + K Sbjct: 1 MAKKTSSKGKLPPGPTPFPIIGNI------LQIDAKDISKSLTKFSECYGPVFTVYLGMK 54 Query: 83 TSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVID 142 +V++ E+VK+ L+ + R + + G G ++ N + W + RR Sbjct: 55 PTVVLHGYEAVKEALVDLG---EEFAGRGSVPILEKVSKGLG-IAFSNAKTWKEMRRFSL 110 Query: 143 LAFSRSSL--VSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKA----A 196 + + S+ + E+A LVE L + +P +L +++ Sbjct: 111 MTLRNFGMGKRSIEDRIQEEARCLVEEL--RKTNASPCDPTFILGCAPCNVICSVIFHNR 168 Query: 197 FGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRD 256 F + L + L + V+L+ N L + + ++ +++ + Sbjct: 169 FDYKDEEFLKLMESLHENVELLGTPWLQVYNNFPALLDYFPGIHKTLLKNADYIKNFIME 228 Query: 257 WVQRRREALKRGEEVPADILTQILKAEEGAQDDEGLLDNFV----TFFIAGHETSANHLA 312 V+ ++ L P D + L E + E L++ V F AG ET++ L Sbjct: 229 KVKEHQKLLDVNN--PRDFIDCFLIKMEQENNLEFTLESLVIAVSDLFGAGTETTSTTLR 286 Query: 313 FTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAW-GTF 371 ++++ L + PE+ AR+Q E++ VIG R +D R+ Y V+ E R Sbjct: 287 YSLLLLLKHPEVAARVQEEIERVIGRHRSPCMQDRSRMPYTDAVIHEIQRFIDLLPTNLP 346 Query: 372 RLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRF--GPGAPKPRFTYFP 429 + + +P T ++ S + + F +P F+P F G K + P Sbjct: 347 HAVTRDVRFRNYFIPKGTDIITSLTSVLHDEKAFPNPKVFDPGHFLDESGNFKKSDYFMP 406 Query: 430 FSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPVLCTLRPR 489 FS G R C+G+ A+ME+ + + +LQ + Q+ ++P D + T Sbjct: 407 FSAGKRMCVGEGLARMELFLFLTSILQNFKL------------QSLVEPKD-LDITAVVN 453 Query: 490 GWQPAPP 496 G+ PP Sbjct: 454 GFVSVPP 460 >4GQS-A nrPDB Length = 477 Score = 358 bits (918), Expect = 4e-99, Method: Composition-based stats. Identities = 95/477 (19%), Positives = 182/477 (38%), Gaps = 41/477 (8%) Query: 36 PPRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKK 95 PP P+ LP ++ + + + +K YGPV + + V++ E VK+ Sbjct: 13 PPGPT----PLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKE 68 Query: 96 FLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSL--VSL 153 L+ + + L R FG + N +RW + RR + + S+ Sbjct: 69 ALIDLGEEFSGRGHFPL-AERANRGFG---IVFSNGKRWKEIRRFSLMTLRNFGMGKRSI 124 Query: 154 METFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKA----AFGMETSMLLGAQK 209 + E+A LVE L + +P +L +++ F + L + Sbjct: 125 EDRVQEEARCLVEEL--RKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLME 182 Query: 210 PLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGE 269 L++ ++++ N + ++ +++ F+ + V+ +E++ Sbjct: 183 KLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINN 242 Query: 270 EVPADILTQILKAEEGAQDD-------EGLLDNFVTFFIAGHETSANHLAFTVMELSRQP 322 P D + L E + + E L+ AG ET++ L + ++ L + P Sbjct: 243 --PRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHP 300 Query: 323 EIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAW-GTFRLLEEETLID 381 E+ A++Q E++ V+G R +D G + Y V+ E R + + Sbjct: 301 EVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFR 360 Query: 382 GVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGP--GAPKPRFTYFPFSLGHRSCIG 439 +P T +L S + + F +P F+P F G K + PFS G R C+G Sbjct: 361 NYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVG 420 Query: 440 QQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPVLCTLRPRGWQPAPP 496 + A+ME+ + + +LQ + + K LD G+ PP Sbjct: 421 EGLARMELFLFLTFILQNFNLKSL----------IDPKDLDTTPVV---NGFASVPP 464 >6DA2-A nrPDB Length = 487 Score = 348 bits (893), Expect = 3e-96, Method: Composition-based stats. Identities = 115/474 (24%), Positives = 218/474 (45%), Gaps = 28/474 (5%) Query: 33 IPGPPRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPES 92 IPGP P LG++ + K G + D ++ KKYG V + + +T P+ Sbjct: 18 IPGP-TPLPFLGNILSYHK-----GFCMFD--MECHKKYGKVWGFYDGQQPVLAITDPDM 69 Query: 93 VKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVS 152 +K L+ Y+ + + FG F + +S E W + R ++ F+ L Sbjct: 70 IKTVLVKECYSVFTN-----RRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKE 124 Query: 153 LMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLS 212 ++ + + LV L +A+ PV+++D+ +MD++ +FG+ L Q P Sbjct: 125 MVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFV 184 Query: 213 QAVKLMLE-GITASRNTLAKFLPGKRKQLREVRESI--RFLRQVGRDWVQRRREA-LKRG 268 + K +L P L + + R + R V+R +E+ L+ Sbjct: 185 ENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDT 244 Query: 269 EEVPADILTQILKAEEGAQD-------DEGLLDNFVTFFIAGHETSANHLAFTVMELSRQ 321 ++ D L ++ ++ + D L+ + F AG+ET+++ L+F + EL+ Sbjct: 245 QKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATH 304 Query: 322 PEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLID 381 P++ +LQ E+D V+ +K ++ + +++YL V+ E+LRL+P A R+ +++ I+ Sbjct: 305 PDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEIN 364 Query: 382 GVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYF--PFSLGHRSCIG 439 G+ +P ++ +Y + R Y+ +P F P+RF Y PF G R+CIG Sbjct: 365 GMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIG 424 Query: 440 QQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQA--TLKPLDPVLCTLRPRGW 491 +FA M +K+ + ++LQ F+ + L+ L+P PV+ + R Sbjct: 425 MRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESRDG 478 >6B82-A nrPDB Length = 509 Score = 345 bits (885), Expect = 2e-95, Method: Composition-based stats. Identities = 95/487 (19%), Positives = 191/487 (39%), Gaps = 30/487 (6%) Query: 33 IPGPPRPSFLLGHLPCFWKKDE-VGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPE 91 +P R L LP V F D KKYG + + + +IV + Sbjct: 18 VPAGNRSPPSLPSLPIIGSLMSLVSDSPPHIFFQDLQKKYGDLYSLMMGSHKLLIVNNHH 77 Query: 92 SVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAF--SRSS 149 K+ L+ + + G+ + W R+++ A Sbjct: 78 HAKEILIKKGKIFAGRPRTVTTDLLTRD--GKDIAFADYSSTWKFHRKMVHGALCMFGEG 135 Query: 150 LVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQK 209 VS+ + +A + E+L + + V + LT +++ F + Sbjct: 136 SVSIEKIICREASSMCEVLTESQN--SAVDLGPELTRAVTNVVCALCFNSSYKRGDAEFE 193 Query: 210 PLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALK--R 267 + Q + +++ T ++++L P + + +R + +Q++ E K Sbjct: 194 SMLQYSQGIVD--TVAKDSLVDIFPWLQIFPNKDLRILRQCISIRDKLLQKKYEEHKVTY 251 Query: 268 GEEVPADILTQILKAE-----------EGAQDDEGLLDNFVTFFIAGHETSANHLAFTVM 316 + V D+L +L+A+ + ++ +L F AG ET+ L +++ Sbjct: 252 SDNVQRDLLDALLRAKRSSENNNSSTRDVGLTEDHVLMTVGEIFGAGVETTTTTLKWSIA 311 Query: 317 ELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAW-GTFRLLE 375 L P++ ++Q E+D IG +R+ D G L YL + E +R+ P + + Sbjct: 312 YLVHNPQVQRKIQEELDSKIGKERHPQLSDRGNLPYLEATICEVMRIRPVSPLLIPHVAL 371 Query: 376 EETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRF----GPGAPKPRFTYFPFS 431 +++ + V T ++ + + + + +++P F+P RF G G P +Y PF Sbjct: 372 QDSSVGEYTVQKGTRVVINMWSLHHDEKEWKNPELFDPGRFLNEEGDGLCCPSGSYLPFG 431 Query: 432 LGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFG---LQEQATLKPLDPVLCTLRP 488 G R C+G+ A+ME+ + +A +LQR + GQ + L+P + Sbjct: 432 AGVRVCLGEALAKMELFLFLAWILQRFTLEMPTGQPLPDLQGKFGVVLQPKKFKVVAKVR 491 Query: 489 RGWQPAP 495 W+ +P Sbjct: 492 ADWEKSP 498 >5VEU-A nrPDB Length = 480 Score = 344 bits (883), Expect = 4e-95, Method: Composition-based stats. Identities = 111/473 (23%), Positives = 212/473 (44%), Gaps = 27/473 (5%) Query: 33 IPGPPRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPES 92 IPGP P LLG++ + + L + KKYG + + +T P+ Sbjct: 17 IPGP-TPLPLLGNVLSY-------RQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDV 68 Query: 93 VKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVS 152 ++ L+ Y+ + + G F + +S E W + R ++ F+ L Sbjct: 69 IRTVLVKECYSVFTN-----RRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKE 123 Query: 153 LMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLS 212 + + + LV L +A+ PV+++D+ +MD++ +FG+ L Q P Sbjct: 124 MFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFV 183 Query: 213 QAVKLMLE-GITASRNTLAKFLPGKRKQLREVRESI--RFLRQVGRDWVQRRREA-LKRG 268 ++ K L+ G P + S+ + V R +++ L Sbjct: 184 ESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDK 243 Query: 269 EEVPADILTQILKAEEGAQD-------DEGLLDNFVTFFIAGHETSANHLAFTVMELSRQ 321 ++ D L ++ ++ + D L + F AG+ET+++ L+FT+ EL+ Sbjct: 244 QKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATH 303 Query: 322 PEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLID 381 P++ +LQ E+D V+ +K ++ + +++YL V+ E+LRL+P A R +++ I+ Sbjct: 304 PDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEIN 363 Query: 382 GVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPK-PRFTYFPFSLGHRSCIGQ 440 GV +P + ++ TY + Y+ +P F P+RF + Y PF G R+CIG Sbjct: 364 GVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGM 423 Query: 441 QFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQ--EQATLKPLDPVLCTLRPRGW 491 +FA M +K+ + ++LQ F+ + L+ Q L+P P++ + R Sbjct: 424 RFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSRDG 476 >5E58-A nrPDB Length = 493 Score = 340 bits (873), Expect = 5e-94, Method: Composition-based stats. Identities = 98/430 (22%), Positives = 173/430 (40%), Gaps = 30/430 (6%) Query: 51 KKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYR 110 ++ + F+ +KYG V V++ + V++ E++++ L+ ++ R Sbjct: 42 NLLQMDRGGFLNSFMRIREKYGDVFTVHLGPRPVVMLYGTEAIREALVD---QAEAFSGR 98 Query: 111 ALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSL--VSLMETFNEKAEQLVEIL 168 V + G++ N ERW RR + S+ + E+A+ LVE L Sbjct: 99 GTIAVIKPVIGDYGMIF-SNGERWKVLRRFSLATMRDFGMGKRSVEDRIQEEAQCLVEEL 157 Query: 169 EAKADGQTPVSMQDMLTYTAMDILAKAAFGME----TSMLLGAQKPLSQAVKLMLE---G 221 + P+ + +I+ FG L + LM Sbjct: 158 QK--SQGAPLDPTFLFQCITANIICSIVFGERYDYKDRQFLRLLDLFYRTFSLMSSFSSQ 215 Query: 222 ITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILK 281 + + K+ PG +Q+ +++ + V++ R L P D + L Sbjct: 216 VFELFSGFMKYFPGAHRQITR---NLQEILDYVGQSVEKHRATLDPSN--PRDFIDTYLL 270 Query: 282 AEEGAQD-------DEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDE 334 E + + LL + ++ F AG ET++ L + + + + P + ++Q E+D+ Sbjct: 271 RMEKEKSNQHTEFHHQNLLISVLSLFFAGTETTSTTLRYGFLLMLKYPHVAEKVQKEIDQ 330 Query: 335 VIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAW-GTFRLLEEETLIDGVRVPGNTPLLF 393 VIGS R ED ++ Y V+ E R A G + ++TL G +P NT + Sbjct: 331 VIGSHRLPTLEDRTKMPYTDAVIHEIQRFSDLAPIGAPHKVTKDTLFRGYLLPKNTEVYP 390 Query: 394 STYVMGRMDTYFEDPLTFNPDRF--GPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVM 451 YFE P TFNPD F GA K + PFS+G R C+G+ A+ E+ + Sbjct: 391 ILSSALHDPQYFEQPGTFNPDHFLDANGALKKSEAFMPFSIGKRICLGEGIARNELFLFF 450 Query: 452 AKLLQRLEFR 461 +LQ Sbjct: 451 TTILQNFSVS 460 >4H1N-A nrPDB Length = 479 Score = 339 bits (868), Expect = 2e-93, Method: Composition-based stats. Identities = 107/471 (22%), Positives = 186/471 (39%), Gaps = 37/471 (7%) Query: 23 VHRARSRYEHIPGPPRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHK 82 + + S +P P P +LG+L ++ + L FL +KYG V V + + Sbjct: 1 MAKKTSSKGKLPPGPSPLPVLGNL------LQMDRKGLLRSFLRLREKYGDVFTVYLGSR 54 Query: 83 TSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVID 142 V++ +++++ L+ ++ R V G G++ N ERW RR Sbjct: 55 PVVVLCGTDAIREALVD---QAEAFSGRGKIAVVDPIFQGYGVIF-ANGERWRALRRFSL 110 Query: 143 LAFSRSSL--VSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGME 200 + S+ E E+A LVE L ++ +I+ FG Sbjct: 111 ATMRDFGMGKRSVEERIQEEARCLVEELRKSKGALLDNTLLFHSI--TSNIICSIVFGKR 168 Query: 201 TSM-------LLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQV 253 LL + + + K+ PG +Q+ +++ + Sbjct: 169 FDYKDPVFLRLLDLFFQSFSLISSFSSQVFELFSGFLKYFPGTHRQIYR---NLQEINTF 225 Query: 254 GRDWVQRRREALKRGEEVPADILT-QILKAEEGAQD------DEGLLDNFVTFFIAGHET 306 V++ R L P D + +L+ E+ D + L+ ++ F AG ET Sbjct: 226 IGQSVEKHRATLDPSN--PRDFIDVYLLRMEKDKSDPSSEFHHQNLILTVLSLFAAGTET 283 Query: 307 SANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPP 366 ++ L + + + + P + R+Q E+++VIGS R +D ++ Y V+ E RL Sbjct: 284 TSTTLRYGFLLMLKYPHVTERVQKEIEQVIGSHRPPALDDRAKMPYTDAVIHEIQRLGDL 343 Query: 367 AW-GTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRF--GPGAPKP 423 G + ++T G +P NT + YFE P TFNP F GA K Sbjct: 344 IPFGVPHTVTKDTQFRGYVIPKNTEVFPVLSSALHDPRYFETPNTFNPGHFLDANGALKR 403 Query: 424 RFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEF-RLVPGQRFGLQEQ 473 + PFSLG R C+G+ A+ E+ + +LQ VP + L + Sbjct: 404 NEGFMPFSLGKRICLGEGIARTELFLFFTTILQNFSIASPVPPEDIDLTPR 454 >5E0E-A nrPDB Length = 463 Score = 333 bits (854), Expect = 1e-91, Method: Composition-based stats. Identities = 99/432 (22%), Positives = 170/432 (39%), Gaps = 30/432 (6%) Query: 51 KKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYR 110 ++ + F +KYG V V++ + V++ E++++ L+ ++ R Sbjct: 14 NLLQMDRGGFLNSFRRIREKYGDVFTVHLGPRPVVMLYGTEAIREALVD---QAEAFSGR 70 Query: 111 ALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSL--VSLMETFNEKAEQLVEIL 168 V G G+V N ERW RR + + S+ E E+A LVE Sbjct: 71 GTIAVVEPIFRGYGVVF-ANGERWKALRRFSLVTMRDFGMGKRSVEERIQEEARCLVEEF 129 Query: 169 EAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSM-------LLGAQKPLSQAVKLMLEG 221 + P+ + +I+ FG LL + Sbjct: 130 --RKSQGAPLDPTFLFQCITANIICSIVFGERFDYKDHQFLRLLYLFYQSFSLISSFSSQ 187 Query: 222 ITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILK 281 + + K+ PG +Q+ +++ + V++ R L P D + L Sbjct: 188 VFELFSGFLKYFPGTHRQISR---NLQEILDYIGQSVEKHRATLDPS--HPRDFIDTYLL 242 Query: 282 AEEGAQ-------DDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDE 334 E + D + L+ + ++ F AG ETS+ L + + + + P + ++Q E+D+ Sbjct: 243 RMEKEKSNQHTEFDHQNLVISVLSLFFAGTETSSTTLRYGFLLMLKYPHVAEKVQKEIDQ 302 Query: 335 VIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAW-GTFRLLEEETLIDGVRVPGNTPLLF 393 VIGS R ED ++ Y V+ E R G + ++TL G +P NT + Sbjct: 303 VIGSHRLPTLEDRTKMPYTEAVIYEIQRFSDLIPIGVPHKVTKDTLFRGYLLPKNTEVYP 362 Query: 394 STYVMGRMDTYFEDPLTFNPDRF--GPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVM 451 YFE P TFNPD F GA K + PFS+G R C+G+ A+ E+ + Sbjct: 363 ILSSALHDPQYFEQPDTFNPDHFLDANGALKKSEAFMPFSIGKRICLGEGIARNELFLFF 422 Query: 452 AKLLQRLEFRLV 463 +LQ Sbjct: 423 TTILQNFSLSSP 434 >3IBD-A nrPDB Length = 476 Score = 332 bits (850), Expect = 3e-91, Method: Composition-based stats. Identities = 102/458 (22%), Positives = 175/458 (38%), Gaps = 27/458 (5%) Query: 51 KKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYR 110 ++ R L FL + +KYG V V++ + V++ E++++ L+ + Sbjct: 23 NLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKI 82 Query: 111 ALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSL--VSLMETFNEKAEQLVEIL 168 A+ F G G++ N RW RR + S+ E E+A+ L+E L Sbjct: 83 AMVDPF---FRGYGVIF-ANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEEL 138 Query: 169 EAKADGQTPVSMQDMLTYTAMDILAKAAFGME----TSMLLGAQKPLSQAVKLMLEGITA 224 + + + +I+ FG L Q L+ Sbjct: 139 --RKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQ 196 Query: 225 SRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEE 284 + FL R+V ++++ + V++ RE L P D++ L E Sbjct: 197 LFELFSGFLKHFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPS--APRDLIDTYLLHME 254 Query: 285 GAQD-------DEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIG 337 + + L N ++ F AG ET++ L + + + + P + R+ E+++VIG Sbjct: 255 KEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIG 314 Query: 338 SKRYLDFEDLGRLQYLSQVLKESLRLYPPAW-GTFRLLEEETLIDGVRVPGNTPLLFSTY 396 R + D ++ Y V+ E R G ++ + T G +P +T + Sbjct: 315 PHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILS 374 Query: 397 VMGRMDTYFEDPLTFNPDRF--GPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKL 454 YFE P FNPD F GA K + PFSLG R C+G+ A+ E+ + + Sbjct: 375 TALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTI 434 Query: 455 LQRLEF-RLVPGQRFGL--QEQATLKPLDPVLCTLRPR 489 LQ V + L QE K PR Sbjct: 435 LQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLPR 472 >3E6I-A nrPDB Length = 476 Score = 332 bits (850), Expect = 3e-91, Method: Composition-based stats. Identities = 89/461 (19%), Positives = 176/461 (38%), Gaps = 31/461 (6%) Query: 23 VHRARSRYEHIPGPPRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHK 82 + + S +P P P ++G+L ++ + + F A+++GPV + V + Sbjct: 1 MAKKTSSKGKLPPGPFPLPIIGNL------FQLELKNIPKSFTRLAQRFGPVFTLYVGSQ 54 Query: 83 TSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVID 142 V++ ++VK+ L+ Y + L R G + N W RR Sbjct: 55 RMVVMHGYKAVKEALLD--YKDEFSGRGDLPAFHAHRDRG---IIFNNGPTWKDIRRFSL 109 Query: 143 LAFSRSSL--VSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDIL----AKAA 196 + +A L+E L + P ++ +++ + Sbjct: 110 TTLRNYGMGKQGNESRIQREAHFLLEAL--RKTQGQPFDPTFLIGCAPCNVIADILFRKH 167 Query: 197 FGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRD 256 F L ++ L+ N FL R+V +++ +++ + Sbjct: 168 FDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSE 227 Query: 257 WVQRRREALKRGEEVPADILTQILKAEEGAQ-------DDEGLLDNFVTFFIAGHETSAN 309 V+ ++L P D+ +L E + +G+ F AG ET++ Sbjct: 228 RVKEHHQSLDP--NCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTST 285 Query: 310 HLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWG 369 L + ++ L + PEI +L E+D VIG R +D + Y+ V+ E R Sbjct: 286 TLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPS 345 Query: 370 -TFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFT-- 426 +T+ G +P T ++ + + + F DP F P+ F K +++ Sbjct: 346 NLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDY 405 Query: 427 YFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQR 467 + PFS G R C G+ A+ME+ +++ +LQ + + + Sbjct: 406 FKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPK 446 >2PG7-A nrPDB Length = 476 Score = 325 bits (834), Expect = 2e-89, Method: Composition-based stats. Identities = 96/460 (20%), Positives = 190/460 (41%), Gaps = 40/460 (8%) Query: 23 VHRARSRYEHIPGPPRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHK 82 + + S +P P P LP ++ + + + +++YGPV +++ + Sbjct: 1 MAKKTSSKGKLPPGPTP------LPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPR 54 Query: 83 TSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVID 142 V++ ++V++ L+ + R Q F G G+V N ER + RR Sbjct: 55 RVVVLCGHDAVREALVD---QAEEFSGRGEQATFDWVFKGYGVVF-SNGERAKQLRRFSI 110 Query: 143 LAFSRSSL--VSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGME 200 + + E E+A L++ L + G + L+ T ++++ FG Sbjct: 111 ATLRDFGVGKRGIEERIQEEAGFLIDAL--RGTGGANIDPTFFLSRTVSNVISSIVFGDR 168 Query: 201 TSMLLGAQKPLSQAVKLMLE-------GITASRNTLAKFLPGKRKQLREVRESIRFLRQV 253 L + + + + + +++ K LPG ++Q ++ + + Sbjct: 169 FDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLE----- 223 Query: 254 GRDWVQRRREALKR--GEEVPADILTQIL---KAEEGAQDDE----GLLDNFVTFFIAGH 304 D++ ++ E +R P D + L + EE + E L+ + F+ G Sbjct: 224 --DFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLQLFVGGT 281 Query: 305 ETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLY 364 ET + L + + L + PE+ A++ E+D VIG R FED ++ Y+ V+ E R Sbjct: 282 ETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFG 341 Query: 365 PPAWG-TFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRF--GPGAP 421 R ++++T +P T + + R ++F +P FNP F G Sbjct: 342 DVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQF 401 Query: 422 KPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFR 461 K + PFS+G R+C G+ A+ME+ + ++Q + Sbjct: 402 KKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLK 441 >3MZS-A nrPDB Length = 486 Score = 318 bits (816), Expect = 3e-87, Method: Composition-based stats. Identities = 98/479 (20%), Positives = 182/479 (37%), Gaps = 20/479 (4%) Query: 28 SRYEHIPGPPRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIV 87 Y IP P +L +L FW+ E G + + ++ +KYGP+ R + + SV + Sbjct: 8 RPYSEIPSPGDNGWL--NLYHFWR--EKGSQRIHFRHIENFQKYGPIYREKLGNLESVYI 63 Query: 88 TSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVI-DLAFS 146 PE V + G++ + + W K R V+ + Sbjct: 64 IHPEDVAHLFKFEGSYPERYDIPPWLAYHRYYQKPIGVLFKKSG-TWKKDRVVLNTEVMA 122 Query: 147 RSSLVSLMETFNEKAEQLVEILEAK----ADGQTPVSMQDMLTYTAMDILAKAAFGMETS 202 ++ + + N ++ V +L + G+ +++ L + A + + FG Sbjct: 123 PEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLG 182 Query: 203 MLLGAQKPLSQ----AVKLMLEGITASRNTLAKFLPGKR-KQLREVRESIRFLRQVGRDW 257 ML P +Q AV M N + R K R+ + + + Sbjct: 183 MLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKAEKY 242 Query: 258 VQRRREALKRGEEVPA--DILTQILKAEEGAQDDEGLLDNFVTFFIAGHETSANHLAFTV 315 + + L+R E IL +LK+E+ +D + N G T++ L + + Sbjct: 243 TEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLED--VKANITEMLAGGVNTTSMTLQWHL 300 Query: 316 MELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLE 375 E++R + L+ EV + L + L +KE+LRL+P + R E Sbjct: 301 YEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPE 360 Query: 376 EETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPK-PRFTYFPFSLGH 434 + ++ +P T + + Y MGR +F P F+P R+ F F G Sbjct: 361 SDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGV 420 Query: 435 RSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPVLCTLRPRGWQP 493 R C+G++ A++E+ + + +L+ + + L P P+ RP P Sbjct: 421 RQCVGRRIAELEMTLFLIHILENFKVEMQHIGDVDTIFNLILTPDKPIFLVFRPFNQDP 479 >3N9Z-A nrPDB Length = 487 Score = 318 bits (814), Expect = 4e-87, Method: Composition-based stats. Identities = 98/483 (20%), Positives = 180/483 (37%), Gaps = 21/483 (4%) Query: 24 HRARSRYEHIPGPPRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKT 83 R+ + IP P +L +L FW+ E G + + +KYGP+ R + + Sbjct: 2 TRSPRPFNEIPSPGDNGWL--NLYHFWR--ETGTHKVHLHHVQNFQKYGPIYREKLGNVE 57 Query: 84 SVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVI-D 142 SV V PE V S N + + G++ + + W K R + Sbjct: 58 SVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKS-AAWKKDRVALNQ 116 Query: 143 LAFSRSSLVSLMETFNEKAEQLVEILEAK----ADGQTPVSMQDMLTYTAMDILAKAAFG 198 + + + + + + V +L + G + D L A + + FG Sbjct: 117 EVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFG 176 Query: 199 METSMLLGAQKPLSQ----AVKLMLEGITASRNTLAKFLPGKR-KQLREVRESIRFLRQV 253 ML P +Q A+ M N R K ++ + + Sbjct: 177 ERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSK 236 Query: 254 GRDWVQRRREALKRGEEVPAD---ILTQILKAEEGAQDDEGLLDNFVTFFIAGHETSANH 310 + Q L++ V D IL ++L + E + N G +T++ Sbjct: 237 ADIYTQNFYWELRQKGSVHHDYRGILYRLL--GDSKMSFEDIKANVTEMLAGGVDTTSMT 294 Query: 311 LAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGT 370 L + + E++R ++ L+AEV + L + L +KE+LRL+P + Sbjct: 295 LQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTL 354 Query: 371 FRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRF-TYFP 429 R L + ++ +P T + + Y +GR T+F DP F+P R+ + Sbjct: 355 QRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLG 414 Query: 430 FSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPVLCTLRPR 489 F G R C+G++ A++E+ + + +L+ + G L P P+ T P Sbjct: 415 FGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKPISFTFWPF 474 Query: 490 GWQ 492 + Sbjct: 475 NQE 477 >4R20-A nrPDB Length = 486 Score = 317 bits (811), Expect = 9e-87, Method: Composition-based stats. Identities = 100/451 (22%), Positives = 187/451 (41%), Gaps = 31/451 (6%) Query: 59 VLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGE 118 +F + +YGP+ + +++V+ V++ L+ + + + Sbjct: 40 PPHLLFTQLSSQYGPLFGLYAGPHLTLVVSEIGLVREVLLQRGREFAGRPKMVTTDLLTQ 99 Query: 119 RLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVS--LMETFNEKAEQLVEILEAKADGQT 176 G+ + W RR++ +F+ S L E A+ L E L+A + Sbjct: 100 G--GKDIAFADYSPLWKNHRRLVHSSFTLFGEGSNKLQTIVQEAADSLCEELQACRGQSS 157 Query: 177 PVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITA--SRNTLAKFLP 234 + +L +++ + F S P Q V +GI +R L P Sbjct: 158 --DLSVVLMRAVTNVICRLVF----SSSYQPSDPELQTVIQYNDGIVQTIARGGLVDIFP 211 Query: 235 GKR----KQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEE------ 284 R K L+ ++E + Q+ + +++L GE P D+L +L ++ Sbjct: 212 WLRIFPNKDLKRLKECVSIRDQLLYKKLLEHKKSLTPGE--PRDLLDALLIGQQRGSGGA 269 Query: 285 GAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDF 344 ++ +L F AG ET++ L +T+ L P++ R+QAE+DE +G R Sbjct: 270 DDITEDHVLMTAAEAFGAGVETTSTTLLWTIAFLLHHPQLQERVQAELDECVGVDRPPCL 329 Query: 345 EDLGRLQYLSQVLKESLRLYPPAWG-TFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDT 403 D L L VL E +R+ P + + ++T + G VP T +L + + + Sbjct: 330 SDRPHLPLLDAVLCEVMRIRPVSPILIPHVAMQDTSLGGHSVPKGTRVLVNMWAIHHDPK 389 Query: 404 YFEDPLTFNPDRF--GPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFR 461 +++ P FNP+RF G K + ++ PF G R C+G+ A++E+ + +++ LQR F Sbjct: 390 HWDQPEQFNPERFLEPSGKKKTQSSFLPFGAGPRVCVGESLARIELFLFVSRPLQRFSFS 449 Query: 462 LVPG---QRFGLQEQATLKPLDPVLCTLRPR 489 + L+P T+ PR Sbjct: 450 CPSEASLPDLQGRFGVVLQPERY-TVTVTPR 479 >5UYS-A nrPDB Length = 494 Score = 313 bits (801), Expect = 1e-85, Method: Composition-based stats. Identities = 95/459 (20%), Positives = 178/459 (38%), Gaps = 37/459 (8%) Query: 41 FLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMST 100 L+G LP G + + F KKYGP+ V + KT+VIV + K+ L+ Sbjct: 17 PLVGSLP----FLPRHGH-MHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKK 71 Query: 101 KYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVI--DLAFSRSSLVSLMETFN 158 + + A + +G+ + W RR+ A + L + Sbjct: 72 GKDFSGRPQMATLDIASNNR--KGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIIC 129 Query: 159 EKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLM 218 ++ L ++L + + + ++++ F P ++ Sbjct: 130 QEISTLCDMLA--THNGQSIDISFPVFVAVTNVISLICFNTSYKNG----DPELNVIQNY 183 Query: 219 LEGITA--SRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRG--EEVPAD 274 EGI S+++L +P + + E ++ ++ D + + E K + + Sbjct: 184 NEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITN 243 Query: 275 ILTQILKA-------------EEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQ 321 +L +++A + D +L F AG ET+ + + +T+ L Sbjct: 244 MLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHN 303 Query: 322 PEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWG-TFRLLEEETLI 380 P++ +L E+D+ +G R D RL L ++E LRL P A ++ I Sbjct: 304 PQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSI 363 Query: 381 DGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAP----KPRFTYFPFSLGHRS 436 V T ++ + + + + + P F P+RF A P +Y PF G RS Sbjct: 364 GEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRS 423 Query: 437 CIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQAT 475 CIG+ A+ E+ ++MA LLQR + + + E Sbjct: 424 CIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIP 462 >4R1Z-A nrPDB Length = 439 Score = 312 bits (800), Expect = 2e-85, Method: Composition-based stats. Identities = 84/440 (19%), Positives = 176/440 (40%), Gaps = 29/440 (6%) Query: 79 VFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQR 138 + +IV + K+ L+ + + G+ + W R Sbjct: 1 MGSHKLLIVNNHHHAKEILIKKGKIFAGRPRTVTTDLLTRD--GKDIAFADYSSTWKFHR 58 Query: 139 RVIDLAF--SRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAA 196 +++ A VS+ + +A + E+L + + V + LT +++ Sbjct: 59 KMVHGALCMFGEGSVSIEKIICREASSMCEVLTESQN--SAVDLGPELTRAVTNVVCALC 116 Query: 197 FGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRD 256 F + + Q + +++ T ++++L P + + +R + Sbjct: 117 FNSSYKRGDAEFESMLQYSQGIVD--TVAKDSLVDIFPWLQIFPNKDLTILRQCISIRDK 174 Query: 257 WVQRRREALK--RGEEVPADILTQILKAE-----------EGAQDDEGLLDNFVTFFIAG 303 +Q++ E K + V D+L +L+A+ + ++ +L F AG Sbjct: 175 LLQKKYEEHKVTYSDNVQRDLLDALLRAKRSSENNNSSTRDVGLTEDHVLMTVGDIFGAG 234 Query: 304 HETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRL 363 ET+ L +++ L P++ ++Q E+D IG +R+ D G L YL ++E LR+ Sbjct: 235 VETTTTVLKWSIAYLVHNPQVQRKIQEELDSKIGKERHPQLSDRGNLPYLEATIREVLRI 294 Query: 364 YPPAW-GTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRF----GP 418 P + + +++ + V T ++ + + + +++P F+P RF G Sbjct: 295 RPVSPLLIPHVALQDSSVGEYTVQKGTRVVINLWSLHHDKKEWKNPELFDPGRFLNEEGD 354 Query: 419 GAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFG---LQEQAT 475 G P +Y PF G R C+G+ A+ME+ + +A +LQR + GQ + Sbjct: 355 GLCCPSGSYLPFGAGVRVCLGEALAKMELFLFLAWILQRFTLEMPTGQPLPDLQGKFGVV 414 Query: 476 LKPLDPVLCTLRPRGWQPAP 495 L+P + W+ +P Sbjct: 415 LQPKKFKVVAKVRADWEKSP 434 >4WMZ-A nrPDB Length = 539 Score = 312 bits (800), Expect = 2e-85, Method: Composition-based stats. Identities = 84/458 (18%), Positives = 180/458 (39%), Gaps = 36/458 (7%) Query: 38 RPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFL 97 RP + +P G + + F + KKYG + + + + P+ +F+ Sbjct: 55 RPPLVFYWIPWVGSAVVYGMKP-YEFFEECQKKYGDIFSFVLLGRVMTVYLGPKG-HEFV 112 Query: 98 MSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETF 157 + K S A +FG+G++ +C R +Q++ + A ++ + S + Sbjct: 113 FNAKLADVSA--EAAYAHLTTPVFGKGVIYDCPNSRLMEQKKFVKGALTKEAFKSYVPLI 170 Query: 158 NEKAEQ-LVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVK 216 E+ + + + + +T ++ M+T M I + + M + Sbjct: 171 AEEVYKYFRDSKNFRLNERTTGTIDVMVTQPEMTIFTASRSLLGKEMRAKLDTDFAYLYS 230 Query: 217 LMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADIL 276 + +G T LP + + R+ + + + ++ +E K + D++ Sbjct: 231 DLDKGFTPINFVFPN-LPLEHYRKRDHAQ-----KAISGTYMSLIKERRKNNDIQDRDLI 284 Query: 277 TQILKA----EEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEV 332 ++K + D+ + + + + G TSA A+ ++ L+ +P++ L E Sbjct: 285 DSLMKNSTYKDGVKMTDQEIANLLIGVLMGGQHTSAATSAWILLHLAERPDVQQELYEEQ 344 Query: 333 DEVI-GSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDG--VRVPGNT 389 V+ G K+ L ++ L + L+Q +KE+LR++ P FR + ++ + +P Sbjct: 345 MRVLDGGKKELTYDLLQEMPLLNQTIKETLRMHHPLHSLFRKVMKDMHVPNTSYVIPAGY 404 Query: 390 PLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKP------------------RFTYFPFS 431 +L S D YF + FN R+ + Y PF Sbjct: 405 HVLVSPGYTHLRDEYFPNAHQFNIHRWNNDSASSYSVGEEVDYGFGAISKGVSSPYLPFG 464 Query: 432 LGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFG 469 G CIG+ FA ++ V+M+ ++ L++ G+ Sbjct: 465 GGRHRCIGEHFAYCQLGVLMSIFIRTLKWHYPEGKTVP 502 >5JLC-A nrPDB Length = 515 Score = 310 bits (794), Expect = 1e-84, Method: Composition-based stats. Identities = 84/457 (18%), Positives = 180/457 (39%), Gaps = 37/457 (8%) Query: 38 RPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFL 97 RP + +P G + + F D KKYG + + + + P+ +F+ Sbjct: 37 RPPLVFYWIPWVGSAIPYGTKP-YEFFEDCQKKYGDIFSFMLLGRIMTVYLGPKG-HEFI 94 Query: 98 MSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETF 157 + K S A + +FG+G++ +C R +Q++ + A ++ + V + Sbjct: 95 FNAKLADVSA--EAAYSHLTTPVFGKGVIYDCPNHRLMEQKKFVKGALTKEAFVRYVPLI 152 Query: 158 NEKAEQLVEILEAKADGQTPVSMQD-MLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVK 216 E+ + + + + D M++ M I + + M + Sbjct: 153 AEEIYKYFRNSKNFKINENNSGIVDVMVSQPEMTIFTASRSLLGKEMRDKLDTDFAYLYS 212 Query: 217 LMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADIL 276 + +G T LP + + R+ + + + ++ +E ++ + D++ Sbjct: 213 DLDKGFTPINFVFPN-LPLEHYRKRDHAQ-----QAISGTYMSLIKERREKNDIQNRDLI 266 Query: 277 TQILKA----EEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEV 332 +++K + D+ + + + + G TSA A+ ++ L+ +P++ L E Sbjct: 267 DELMKNSTYKDGTKMTDQEIANLLIGVLMGGQHTSAATSAWCLLHLAERPDVQEELYQEQ 326 Query: 333 DEVIGSK-RYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDG--VRVPGNT 389 V+ + + L ++DL + L+Q++KE+LRL+ P FR + + I VP + Sbjct: 327 MRVLNNDTKELTYDDLQNMPLLNQMIKETLRLHHPLHSLFRKVMRDVAIPNTSYVVPRDY 386 Query: 390 PLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFT-------------------YFPF 430 +L S + +F P FN R+ A Y PF Sbjct: 387 HVLVSPGYTHLQEEFFPKPNEFNIHRWDGDAASSSAAGGDEVDYGFGAISKGVSSPYLPF 446 Query: 431 SLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQR 467 G CIG+ FA ++ V+M+ ++ +++R Sbjct: 447 GGGRHRCIGELFAYCQLGVLMSIFIRTMKWRYPTEGE 483 >3JUS-A nrPDB Length = 461 Score = 307 bits (785), Expect = 1e-83, Method: Composition-based stats. Identities = 89/453 (19%), Positives = 186/453 (41%), Gaps = 17/453 (3%) Query: 35 GPPRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVK 94 G P ++ +P G + + + +KYGPV + KT + ++ Sbjct: 9 GVKSPPYIFSPIPFLGHAIAFGKSPI-EFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAA 67 Query: 95 KFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLM 154 S + +++ + + +FG+G+ + + +Q++++ + + + Sbjct: 68 LLFNSKNEDLNAE---DVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHV 124 Query: 155 ETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQA 214 ++ ++ E + ++ +++ TA + G E L + ++Q Sbjct: 125 SIIEKETKEYFESWGESGEKNVFEALSELIILTA----SHCLHGKEIRSQLN--EKVAQL 178 Query: 215 VKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPAD 274 + G + + L +LP R + R ++ + +Q+RR++ ++ +++ Sbjct: 179 YADLDGGFSHAAWLLPGWLPLP--SFRRRDRAHREIKDIFYKAIQKRRQSQEKIDDILQT 236 Query: 275 ILTQILKAEEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDE 334 +L K DDE + + +AG TS+ A+ L+R + + E Sbjct: 237 LLDATYKDGRPLTDDE-VAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKT 295 Query: 335 VIGSKRYL-DFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLF 393 V G ++ L L L + +KE+LRL PP R+ + G +P + Sbjct: 296 VCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCV 355 Query: 394 STYVMGRMDTYFEDPLTFNPDRFGPGAPK--PRFTYFPFSLGHRSCIGQQFAQMEVKVVM 451 S V R+ + + L FNPDR+ P +F Y PF G CIG+ FA +++K + Sbjct: 356 SPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIW 415 Query: 452 AKLLQRLEFRLVPGQRFGLQEQATL-KPLDPVL 483 + +L+ EF L+ G + + P +PV+ Sbjct: 416 STMLRLYEFDLIDGYFPTVNYTTMIHTPENPVI 448 >5YLW-A nrPDB Length = 495 Score = 307 bits (785), Expect = 1e-83, Method: Composition-based stats. Identities = 103/481 (21%), Positives = 194/481 (40%), Gaps = 27/481 (5%) Query: 11 AVLLAFGLCCTFVHRARSRYEHIPGPPRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKK 70 A L TF+ R R ++P P P ++G++ ++G VF +K+ Sbjct: 8 AALFFIAATITFLSFRRRR--NLPPGPFPYPIVGNM------LQLGANP-HQVFAKLSKR 58 Query: 71 YGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECN 130 YGP++ +++ +VIV+SPE K+ L + G + Sbjct: 59 YGPLMSIHLGSLYTVIVSSPEMAKEILHRHGQVFSGRTIAQAVHACDHDKISMGFLPVA- 117 Query: 131 YERWHKQRRVID-LAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAM 189 W R++ FS S+ + +K +QL++ ++ +D V +++ T + Sbjct: 118 -SEWRDMRKICKEQMFSNQSMEASQGLRRQKLQQLLDHVQKCSDSGRAVDIREAAFITTL 176 Query: 190 DILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQ-----LREVR 244 ++++ F + + + + + I N A + P R R Sbjct: 177 NLMSATLFSSQATEFDSKATMEFKEIIEGVATIVGVPN-FADYFPILRPFDPQGVKRRAD 235 Query: 245 ESIRFLRQVGRDWVQRRREALKRGEEVP--ADIL---TQILKAEEGAQDDEGLLDNFVTF 299 L ++ R E+ + P D L I++A E + Sbjct: 236 VFFGKLLAKIEGYLNERLESKRANPNAPKKDDFLEIVVDIIQANEFKLKTHHFTHLMLDL 295 Query: 300 FIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKE 359 F+ G +T+ + + + EL P+ +ARL+AE+ V G ++ +D + +L YL V+KE Sbjct: 296 FVGGSDTNTTSIEWAMSELVMNPDKMARLKAELKSVAGDEKIVDESAMPKLPYLQAVIKE 355 Query: 360 SLRLYPPAW-GTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGP 418 +R++PP R E + ++G +P T +L + Y +GR + + DP TF+P+RF Sbjct: 356 VMRIHPPGPLLLPRKAESDQEVNGYLIPKGTQILINAYAIGRDPSIWTDPETFDPERFLD 415 Query: 419 GAPKPR---FTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQAT 475 + + PF G R C G A + + A L+ +++L Sbjct: 416 NKIDFKGQDYELLPFGSGRRVCPGMPLATRILHMATATLVHNFDWKLEDDSTAAADHAGE 475 Query: 476 L 476 L Sbjct: 476 L 476 >6DWN-A nrPDB Length = 491 Score = 304 bits (779), Expect = 5e-83, Method: Composition-based stats. Identities = 91/465 (19%), Positives = 175/465 (37%), Gaps = 38/465 (8%) Query: 34 PGPPRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESV 93 P P L+GH+ K +++YG V+++ + V+++ +++ Sbjct: 13 PPGPWGWPLIGHMLTLGKNP-------HLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTI 65 Query: 94 KKFLMSTKYNKDSKMYRALQTVFGERLFGQGL-VSECNYERWHKQRRVIDLAFSRSSLVS 152 ++ L+ + R F GQ + S + W +RR+ S+ S Sbjct: 66 RQALVRQGDDFKG---RPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIAS 122 Query: 153 ---------LMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSM 203 L E +++AE L+ L+ G + + + +++ FG Sbjct: 123 DPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDH 182 Query: 204 LLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRR-R 262 Q+ LS G A F+P R + + L + ++Q+ + Sbjct: 183 --NHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVK 240 Query: 263 EALKRGEEVP-ADILTQILK---------AEEGAQDDEGLLDNFVTFFIAGHETSANHLA 312 E K E+ DI +++ DE +++ + F AG +T ++ Sbjct: 241 EHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAIS 300 Query: 313 FTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWG-TF 371 +++M L P + ++Q E+D VIG R D L Y+ + E+ R Sbjct: 301 WSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIP 360 Query: 372 RLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKP----RFTY 427 +T + G +P + + + + + +P F P+RF Sbjct: 361 HSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKV 420 Query: 428 FPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQE 472 F +G R CIG+ A+ EV + +A LLQR+EF + G + + Sbjct: 421 IIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDMTP 465 >3L4D-A nrPDB Length = 453 Score = 303 bits (777), Expect = 8e-83, Method: Composition-based stats. Identities = 83/446 (18%), Positives = 170/446 (38%), Gaps = 20/446 (4%) Query: 39 PSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTS-PESVKKFL 97 P + G P + G L L KKYG + +N+ +V + K F Sbjct: 5 PPVVHGTTPFVGHIIQFGKDPL-GFMLKAKKKYGGIFTMNICGNRITVVGDVHQHSKFFT 63 Query: 98 MSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETF 157 + ++Y + VF G+G+ Y R +Q + + + + + Sbjct: 64 PRNEILSPREVYSFMVPVF-----GEGVAYAAPYPRMREQLNFLAEELTVAKFQNFAPSI 118 Query: 158 NEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKL 217 + + ++ K +G+ +++ D + ++ + FG + L A++ +Q + Sbjct: 119 QHEVRKFMKANWNKDEGE--INILDDCSAMIINTACQCLFGEDLRKRLDARQ-FAQLLAK 175 Query: 218 MLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILT 277 M + + L L Q R++ L+ + + + R + + + +D+L Sbjct: 176 MESCLIPAAVFLPWILKLPLPQSYRCRDARAELQDILSEIIIAREKEEAQKDTNTSDLLA 235 Query: 278 QILKA---EEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELS--RQPEIVARLQAEV 332 +L A + + V AG TS ++++ L R +A+L E+ Sbjct: 236 GLLGAVYRDGTRMSQHEVCGMIVAAMFAGQHTSTITTTWSLLHLMDPRNKRHLAKLHQEI 295 Query: 333 DEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLL 392 DE Y + + + + Q +ES+R PP R + + + VP + Sbjct: 296 DEFPAQLNYDNVME--EMPFAEQCARESIRRDPPLVMLMRKVLKPVQVGKYVVPEGDIIA 353 Query: 393 FSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMA 452 S + + + F +P +NP+R + F G CIG++F ++VK V+A Sbjct: 354 CSPLLSHQDEEAFPNPREWNPER---NMKLVDGAFCGFGAGVHKCIGEKFGLLQVKTVLA 410 Query: 453 KLLQRLEFRLVPGQRFGLQEQATLKP 478 +L+ +F L+ + P Sbjct: 411 TVLRDYDFELLGPLPEPNYHTMVVGP 436 >3K9V-A nrPDB Length = 482 Score = 303 bits (775), Expect = 1e-82, Method: Composition-based stats. Identities = 103/471 (21%), Positives = 189/471 (40%), Gaps = 18/471 (3%) Query: 28 SRYEHIPGPPRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIV 87 +PGP L L FWK G + D ++ KKYG + R+ + SV + Sbjct: 21 RNVTDLPGPTNWPLLGSLLEIFWKG---GLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHL 77 Query: 88 TSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSR 147 SP ++ + + + + R GL+ + W + R + Sbjct: 78 GSPSLLEALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMIL-EGQEWQRVRSAFQKKLMK 136 Query: 148 S-SLVSLMETFNEKAEQLVEILEAKADGQTPV-SMQDMLTYTAMDILAKAAFGMETSMLL 205 ++ L + NE +E ++ D + + + L + + + + +L Sbjct: 137 PVEIMKLDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLL- 195 Query: 206 GAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQR----- 260 QK + + I +T K + + + + + + D + + Sbjct: 196 --QKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPC 253 Query: 261 RREALKRGEEVPA-DILTQILKAEEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELS 319 L+R + P D L I + + ++ + L +A ET+AN L + + LS Sbjct: 254 IDNRLQRYSQQPGADFLCDIYQQDHLSK--KELYAAVTELQLAAVETTANSLMWILYNLS 311 Query: 320 RQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETL 379 R P+ RL EV V+ + EDL + YL LKES+RL P T R L++ T+ Sbjct: 312 RNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTV 371 Query: 380 IDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPR-FTYFPFSLGHRSCI 438 + +P T L +T V+G + FED F P+R+ K F + PF +G R CI Sbjct: 372 LGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCI 431 Query: 439 GQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPVLCTLRPR 489 G++ A++++ + + ++Q+ + + + L P + RPR Sbjct: 432 GRRLAELQLHLALCWIIQKYDIVATDNEPVEMLHLGILVPSRELPIAFRPR 482 >3QZ1-A nrPDB Length = 496 Score = 302 bits (773), Expect = 2e-82, Method: Composition-based stats. Identities = 98/471 (20%), Positives = 182/471 (38%), Gaps = 30/471 (6%) Query: 38 RPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFL 97 R L +P F + L L +K GPV R+ + + V++ S ++++ + Sbjct: 26 RNLHLPPLVPGFLHLLQPN---LPIHLLSLTQKLGPVYRLRLGLQEVVVLNSKRTIEEAM 82 Query: 98 MSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYER-WHKQRRVIDLAFSRSSLVSLMET 156 + + + + +R +S +Y W +++ A + S+ Sbjct: 83 IRKWVDFAGRPQIPSYKLVSQRCQD---ISLGDYSLLWKAHKKLTRSALLLGTRSSMEPW 139 Query: 157 FNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQ-AV 215 ++ ++ E + + PV++Q + I+ FG + L+ A Q + Sbjct: 140 VDQLTQEFCERM--RVQAGAPVTIQKEFSLLTCSIICYLTFGNKEDTLVHAFHDCVQDLM 197 Query: 216 KLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADI 275 K + + L ++++I + ++R +E++ G+ D+ Sbjct: 198 KTWDHWSIQILDMVPFLRFFPNPGLWRLKQAIENRDHMVEKQLRRHKESMVAGQW--RDM 255 Query: 276 LTQILKA--------EEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVAR 327 +L+ G + + + V FI G ET+A+ L++ V L PEI R Sbjct: 256 TDYMLQGVGRQRVEEGPGQLLEGHVHMSVVDLFIGGTETTASTLSWAVAFLLHHPEIQRR 315 Query: 328 LQAEVDEVIG---SKRYLDFEDLGRLQYLSQVLKESLRLYPPAW-GTFRLLEEETLIDGV 383 LQ E+D +G S + ++D RL L+ + E LRL P + I G Sbjct: 316 LQEELDRELGPGASCSRVTYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSIFGY 375 Query: 384 RVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFA 443 +P ++ + +T +E P F PDRF P F G R C+G+ A Sbjct: 376 DIPEGMVVIPNLQGAHLDETVWEQPHEFRPDRFLEPGANPSA--LAFGCGARVCLGESLA 433 Query: 444 QMEVKVVMAKLLQRLEFRLVPGQRFGL----QEQATLKPLDPVLCTLRPRG 490 ++E+ VV+A+LLQ P + P L+PRG Sbjct: 434 RLELFVVLARLLQAFTLLPPPVGALPSLQPDPYCGVNLKVQPFQVRLQPRG 484 >4KPA-A nrPDB Length = 494 Score = 302 bits (772), Expect = 3e-82, Method: Composition-based stats. Identities = 105/479 (21%), Positives = 211/479 (44%), Gaps = 34/479 (7%) Query: 31 EHIPGPPRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSP 90 + +P P L +LP V + A + G + + + + ++S Sbjct: 27 KEMPQPKTFGEL-KNLPLLNTDKPV------QALMKIADELGEIFKFEAPGRVTRYLSSQ 79 Query: 91 ESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYER-WHKQRRVIDLAFSRSS 149 +K+ ++++K+ + +AL+ F G GL + +E+ W K ++ +FS+ + Sbjct: 80 RLIKEACDESRFDKN--LSQALK--FVRDFAGDGLFTSWTHEKNWKKAHNILLPSFSQQA 135 Query: 150 LVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQK 209 + + A QLV+ + + + + + +T +D + F + Q Sbjct: 136 MKGYHAMMVDIAVQLVQKW-ERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQP 194 Query: 210 PLSQAVKLMLEGITASRNTLAKF---LPGKRKQLREVRESIRFLRQVGRDWVQRRREALK 266 + M+ + + N L + P + R+ +E I+ + + + R+ + + Sbjct: 195 --HPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRKASGE 252 Query: 267 RGEEVPADILTQILKAEEGA----QDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQP 322 + + D+LT +L ++ DDE + +TF IAGHET++ L+F + L + P Sbjct: 253 QSD----DLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNP 308 Query: 323 EIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDG 382 ++ + E V+ ++ + +L+Y+ VL E+LRL+P A +E+T++ G Sbjct: 309 HVLQKAAEEAARVLVDP-VPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGG 367 Query: 383 -VRVPGNTPLLFSTYVMGRMDTYF-EDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQ 440 + L+ + R T + +D F P+RF + P+ + PF G R+CIGQ Sbjct: 368 EYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQ 427 Query: 441 QFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPVLCTLR----PRGWQPAP 495 QFA E +V+ +L+ +F ++E TLKP + + + P G P+P Sbjct: 428 QFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKP-EGFVVKAKSKKIPLGGIPSP 485 >2WX2-A nrPDB Length = 473 Score = 300 bits (768), Expect = 9e-82, Method: Composition-based stats. Identities = 80/460 (17%), Positives = 174/460 (37%), Gaps = 24/460 (5%) Query: 36 PPRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAK--KYGPVVRVNVFHKTSVIVTSP-ES 92 P P +P + G L + + K G V +++ + IV P E Sbjct: 15 PTDPPVYPVTVPFLGHIVQFGKNPL-EFMQRCKRDLKSG-VFTISIGGQRVTIVGDPHEH 72 Query: 93 VKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVS 152 + F + ++Y + VF G+G+ Y R +Q + + + + Sbjct: 73 SRFFSPRNEILSPREVYTIMTPVF-----GEGVAYAAPYPRMREQLNFLAEELTIAKFQN 127 Query: 153 LMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLS 212 + + + + + +G +++ + ++ + FG + L A+ + Sbjct: 128 FVPAIQHEVRKFMAENWKEDEG--VINLLEDCGAMIINTACQCLFGEDLRKRLNARH-FA 184 Query: 213 QAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVP 272 Q + M + + + L Q RE+ L+++ + + R + + Sbjct: 185 QLLSKMESSLIPAAVFMPWLLRLPLPQSARCREARAELQKILGEIIVAREKEEASKDNNT 244 Query: 273 ADILTQILKA---EEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSR--QPEIVAR 327 +D+L +LKA + + V AG TS +++++ L + + + Sbjct: 245 SDLLGGLLKAVYRDGTRMSLHEVCGMIVAAMFAGQHTSTITTSWSMLHLMHPKNKKWLDK 304 Query: 328 LQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPG 387 L E+DE Y + D + + + ++ES+R PP R+++ E + VP Sbjct: 305 LHKEIDEFPAQLNYDNVMD--EMPFAERCVRESIRRDPPLLMVMRMVKAEVKVGSYVVPK 362 Query: 388 NTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEV 447 + S + + F +P ++P+R K + F G CIGQ+FA ++V Sbjct: 363 GDIIACSPLLSHHDEEAFPNPRLWDPER----DEKVDGAFIGFGAGVHKCIGQKFALLQV 418 Query: 448 KVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPVLCTLR 487 K ++A + +F+L+ + + C ++ Sbjct: 419 KTILATAFREYDFQLLRDEVPDPDYHTMVVGPTLNQCLVK 458 >5VBU-A nrPDB Length = 476 Score = 299 bits (765), Expect = 2e-81, Method: Composition-based stats. Identities = 96/470 (20%), Positives = 189/470 (40%), Gaps = 30/470 (6%) Query: 47 PCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDS 106 P + L L +K+GP+ R+++ + V++ S ++++ ++ + Sbjct: 13 PLAPGFLHLLQPDLPIYLLGLTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAG 72 Query: 107 KMYRALQTVFGERLFGQGLVSECNYER-WHKQRRVIDLAFSRSSLVSLMETFNEKAEQLV 165 + + +S +Y W +++ A S+ + ++ Sbjct: 73 RPEPLTYKLVSRN---YPDLSLGDYSLLWKAHKKLTRSALLLGIRDSMEPVVEQLTQEFC 129 Query: 166 EILEAKADGQTPVSMQDMLTYTAMDILAKAAFGME---TSMLLGAQKPLSQAVKLMLEGI 222 E + +A TPV++++ + I+ FG + +++ K + + +K Sbjct: 130 ERM--RAQPGTPVAIEEEFSLLTCSIICYLTFGDKIKDDNLMPAYYKCIQEVLKTWSHWS 187 Query: 223 TASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKA 282 + + LR ++++I + +++ +E+L G+ D++ +L+ Sbjct: 188 IQIVDVIPFLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQW--RDMMDYMLQG 245 Query: 283 EEGAQDDEG--------LLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDE 334 +EG + V I G ET+AN L++ V+ L PEI RLQ E+D Sbjct: 246 VAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDH 305 Query: 335 VIG---SKRYLDFEDLGRLQYLSQVLKESLRLYPPAW-GTFRLLEEETLIDGVRVPGNTP 390 +G S + ++D RL L+ + E LRL P + I G +P T Sbjct: 306 ELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTV 365 Query: 391 LLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVV 450 ++ + +T +E P F PDRF P F G R C+G+ A++E+ VV Sbjct: 366 IIPNLQGAHLDETVWERPHEFWPDRFLE--PGKNSRALAFGCGARVCLGEPLARLELFVV 423 Query: 451 MAKLLQRLEF----RLVPGQRFGLQEQATLKPLDPVLCTLRPRGWQPAPP 496 + +LLQ +P + L + + + P L+PRG P Sbjct: 424 LTRLLQAFTLLPSGDALPSLQ-PLPHCSVILKMQPFQVRLQPRGMGAHSP 472 >2X2N-A nrPDB Length = 475 Score = 295 bits (754), Expect = 4e-80, Method: Composition-based stats. Identities = 78/463 (16%), Positives = 175/463 (37%), Gaps = 22/463 (4%) Query: 32 HIPGPPRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKY-GPVVRVNVFHKTSVIVTSP 90 ++ P P +P + G L + ++ + +N+ K IV P Sbjct: 11 NVTRPTDPPVYPVTVPILGHIIQFGKSPL-GFMQECKRQLKSGIFTINIVGKRVTIVGDP 69 Query: 91 -ESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSS 149 E + FL + ++Y + VF G+G+ Y R +Q + + + Sbjct: 70 HEHSRFFLPRNEVLSPREVYSFMVPVF-----GEGVAYAAPYPRMREQLNFLAEELTIAK 124 Query: 150 LVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQK 209 + + + + + K +G+ +++ + + ++ + FG + L A++ Sbjct: 125 FQNFVPAIQHEVRKFMAANWDKDEGE--INLLEDCSTMIINTACQCLFGEDLRKRLDARR 182 Query: 210 PLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGE 269 +Q + M + + L L Q E+ L+++ + + R+ A + Sbjct: 183 -FAQLLAKMESSLIPAAVFLPILLKLPLPQSARCHEARTELQKILSEIIIARKAAAVNKD 241 Query: 270 EVPADILTQILKA---EEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSR--QPEI 324 +D+L+ +L A + + V AG TS+ ++++ L + Sbjct: 242 SSTSDLLSGLLSAVYRDGTPMSLHEVCGMIVAAMFAGQHTSSITTTWSMLHLMHPANVKH 301 Query: 325 VARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVR 384 + L+ E++E Y + D + + + +ES+R PP R + + + Sbjct: 302 LEALRKEIEEFPAQLNYNNVMD--EMPFAERCARESIRRDPPLLMLMRKVMADVKVGSYV 359 Query: 385 VPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQ 444 VP + S + + F +P ++P+R K + F G CIGQ+F Sbjct: 360 VPKGDIIACSPLLSHHDEEAFPEPRRWDPER----DEKVEGAFIGFGAGVHKCIGQKFGL 415 Query: 445 MEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPVLCTLR 487 ++VK ++A + +F+L+ + + C ++ Sbjct: 416 LQVKTILATAFRSYDFQLLRDEVPDPDYHTMVVGPTASQCRVK 458 >3DL9-A nrPDB Length = 479 Score = 293 bits (749), Expect = 1e-79, Method: Composition-based stats. Identities = 90/443 (20%), Positives = 178/443 (40%), Gaps = 21/443 (4%) Query: 61 QDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERL 120 ++ YG + +++ ++V++ + VK+ L+ + R +F + Sbjct: 37 HVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKECLVH---QSEIFADRPCLPLFMKMT 93 Query: 121 FGQGLVSECNYERWHKQRRVIDLAFSRSSL--VSLMETFNEKAEQLVEILEAKADGQTPV 178 GL++ W RR+ +F S E+ + + +E P Sbjct: 94 KMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIE--TYKGRPF 151 Query: 179 SMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRK 238 + ++T +I FG + + + + +E ++ L P Sbjct: 152 DFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGI 211 Query: 239 QLREVRESIRFLRQVGRDWVQR--RREALKRGEEVPADILTQILKAEEGAQDD------- 289 + + V D++ R + ++ R ++P + L + ++D Sbjct: 212 LPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSK 271 Query: 290 EGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGR 349 E L+ + IAG ET+ N L + ++ ++ P I ++Q E+D ++G ++D + Sbjct: 272 ENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCK 331 Query: 350 LQYLSQVLKESLRLYPPAW-GTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDP 408 + Y VL E LR G F E+ ++ G +P T ++ + Y + + Y+ DP Sbjct: 332 MPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDP 391 Query: 409 LTFNPDRF--GPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQ 466 F+P+RF G + PFSLG R C+G+ A+ME+ + LLQR Sbjct: 392 EVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHEL 451 Query: 467 RFGLQEQA--TLKPLDPVLCTLR 487 L+ + TL+P ++C R Sbjct: 452 VPDLKPRLGMTLQPQPYLICAER 474 >6AYB-A nrPDB Length = 466 Score = 292 bits (748), Expect = 2e-79, Method: Composition-based stats. Identities = 95/469 (20%), Positives = 198/469 (42%), Gaps = 32/469 (6%) Query: 36 PPRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKK 95 PPR L+ ++ F + +D +KKYG V + K + P+ + Sbjct: 12 PPRVPNLIPYVGSFVSF----AKNPVQFIIDNSKKYGDVFTATILGKEMTFLNHPKILDT 67 Query: 96 FLMSTK-YNKDSKMYRALQTVFGERLFGQGLVSECN-YERWHKQRRVIDLAFSRSSLVSL 153 F +T +YR ++ VF G G+V + + ER +Q + + + + Sbjct: 68 FFKATDNELSLRDVYRFMRPVF-----GTGVVYDADSTERMMEQVKFVSSGLTTARFRVF 122 Query: 154 METFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQ 213 ++ F ++ V+ L + V + +++ + ++ G E L + Sbjct: 123 VDIFEDEIAHKVKEL----GPEGTVDVAELMADLIIFTASRCLLGDEVRQYL-----SEK 173 Query: 214 AVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRG----- 268 + + I + L+ F P R+ ++ + + ++ ++ + +RRE K+ Sbjct: 174 NLGKLYHDIDDGISPLSFFYPSLPAPKRD--KARKAVGEIFQELLDKRREEHKKHPERLL 231 Query: 269 EEVPADILTQILKA---EEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIV 325 +E D++ +L + D + + AG TS+ ++T+M + +++ Sbjct: 232 DESKMDVVDHLLTQKYKDGQELTDVHRIGILIAGLFAGQHTSSITSSWTLMNVISNKKVL 291 Query: 326 ARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRV 385 +++ E +E++GS + LD++ + ++ YL +KE+LR+YPP R+ + + + Sbjct: 292 EKVRKEQEEIMGSDKVLDYDKVMKMDYLEACMKEALRMYPPLIMIMRMARKPRECEQYII 351 Query: 386 PGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTY--FPFSLGHRSCIGQQFA 443 P L+ S V GR + +P F+P+R +F Y PF G CIG+ FA Sbjct: 352 PKGNILVVSPSVAGRCTDTYTNPDVFDPERLTERKEHEKFKYGAVPFGAGRHKCIGENFA 411 Query: 444 QMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPVLCTLRPRGWQ 492 ++VK +++ LL+ + + + P P + R Q Sbjct: 412 LLQVKSIISILLRYFDMEYIGKIPDPSYTSLVVGPSPPTRMRYKLRKQQ 460 >2HI4-A nrPDB Length = 495 Score = 291 bits (744), Expect = 5e-79, Method: Composition-based stats. Identities = 93/467 (19%), Positives = 181/467 (38%), Gaps = 43/467 (9%) Query: 34 PGPPRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESV 93 P P LLGH+ K +++YG V+++ + ++++ +++ Sbjct: 18 PPEPWGWPLLGHVLTLGKNP-------HLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTI 70 Query: 94 KKFLMSTKYNKDSKM--YRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLV 151 ++ L+ + + Y + G+ L S + W +RR+ A + S+ Sbjct: 71 RQALVRQGDDFKGRPDLYTSTLITDGQSLT----FSTDSGPVWAARRRLAQNALNTFSIA 126 Query: 152 S---------LMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMET- 201 S L E +++A+ L+ L+ G + + + +++ FG Sbjct: 127 SDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFP 186 Query: 202 ---SMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWV 258 +L K + V+ G + ++LP L+ + + + V Sbjct: 187 ESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNP--ALQRFKAFNQRFLWFLQKTV 244 Query: 259 QRRREALKRGEEVPADILTQILK-------AEEGAQDDEGLLDNFVTFFIAGHETSANHL 311 Q + + DI + K A E +++ F AG +T + Sbjct: 245 QEHYQDFDK--NSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAI 302 Query: 312 AFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWG-T 370 ++++M L +PEI ++Q E+D VIG +R D +L YL + E+ R Sbjct: 303 SWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTI 362 Query: 371 FRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPG-----APKPRF 425 +T ++G +P + + + + +EDP F P+RF Sbjct: 363 PHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSE 422 Query: 426 TYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQE 472 F +G R CIG+ A+ E+ + +A LLQ+LEF + PG + L Sbjct: 423 KMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTP 469 >5FSA-A nrPDB Length = 490 Score = 289 bits (739), Expect = 2e-78, Method: Composition-based stats. Identities = 88/459 (19%), Positives = 165/459 (35%), Gaps = 42/459 (9%) Query: 37 PRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKF 96 P + +P F G + + F +KYG V + K + P+ +F Sbjct: 4 KTPPLVFYWIPWFGSAASYGQQP-YEFFESCRQKYGDVFSFMLLGKIMTVYLGPKG-HEF 61 Query: 97 LMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMET 156 + + K + S +FG G++ +C R +Q++ A + S + Sbjct: 62 VFNAKLSDVSA--EEAYKHLTTPVFGTGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPK 119 Query: 157 FNEK-----AEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPL 211 E+ L+ K G V M T + I + M + Sbjct: 120 IREEILNYFVTDESFKLKEKTHGVANV----MKTQPEITIFTASRSLFGDEMRRIFDRSF 175 Query: 212 SQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEV 271 +Q + +G T LP R+ + + ++R R + ++ Sbjct: 176 AQLYSDLDKGFTPINFVFPN-LPLPHYWRRDAAQKKISATYMKEIKLRRERGDIDPNRDL 234 Query: 272 PADILTQILKAEEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAE 331 +L + D+ + + + + G TSA+ A+ ++ L +P + + E Sbjct: 235 IDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQE 294 Query: 332 VDEVI----GSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLID--GVRV 385 V E++ G L +EDL +L ++ +KE+LR++ P FR + I V Sbjct: 295 VVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIV 354 Query: 386 PGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPR--------------------- 424 P +L S + YF++P F+P R+ A K Sbjct: 355 PKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGV 414 Query: 425 -FTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRL 462 Y PF G CIG+QFA +++ ++ + L + + Sbjct: 415 SSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRWTI 453 >6CR2-A nrPDB Length = 477 Score = 285 bits (730), Expect = 2e-77, Method: Composition-based stats. Identities = 86/454 (18%), Positives = 180/454 (39%), Gaps = 33/454 (7%) Query: 37 PRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKF 96 P + P G F D KYG + + K + + + F Sbjct: 4 KTPPVVFHWFPFIGSTISYGIDP-YKFFFDCRAKYGDIFTFILLGKKTTVYLGTKG-NDF 61 Query: 97 LMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMET 156 +++ K + + +FG+ +V +C + +Q++ + + +L S + Sbjct: 62 ILNGKLRDVCA--EEVYSPLTTPVFGRHVVYDCPNAKLMEQKKFVKYGLTSDALRSYVPL 119 Query: 157 FNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVK 216 ++ E V+ A + + + + +++ G E ++ Sbjct: 120 ITDEVESFVKNSPAFQGHKGVFDVCKTIAEITIYTASRSLQGKEVRS--KFDSTFAELYH 177 Query: 217 LMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRRE--ALKRGEEVPAD 274 + G L R+ + R L + + ++ RR+ + K E++ + Sbjct: 178 NLDMGFAPINFMLPW---APLPHNRKRDAAQRKLTETYMEIIKARRQAGSKKDSEDMVWN 234 Query: 275 ILTQILKAEEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDE 334 +++ + K DE + + +AG +S++ ++ V+ L+ +P+I+ L E Sbjct: 235 LMSCVYKNGTPV-PDEEIAHMMIALLMAGQHSSSSTASWIVLRLATRPDIMEELYQEQIR 293 Query: 335 VIGSKRYL-DFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDG--VRVPGNTPL 391 V+GS +++L +L ++V+KE+LRL+ P R ++ +DG +P + + Sbjct: 294 VLGSDLPPLTYDNLQKLDLHAKVIKETLRLHAPIHSIIRAVKNPMAVDGTSYVIPTSHNV 353 Query: 392 LFSTYVMGRMDTYFEDPLTFNPDRFGPG------------------APKPRFTYFPFSLG 433 L S V R + +F +PL +NP R+ + Y PF G Sbjct: 354 LSSPGVTARSEEHFPNPLEWNPHRWDENIAASAEDDEKVDYGYGLVSKGTNSPYLPFGAG 413 Query: 434 HRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQR 467 CIG+QFA +++ + A L++ FR +PG Sbjct: 414 RHRCIGEQFAYLQLGTITAVLVRLFRFRNLPGVD 447 >3EL3-A nrPDB Length = 467 Score = 284 bits (727), Expect = 6e-77, Method: Composition-based stats. Identities = 111/465 (23%), Positives = 199/465 (42%), Gaps = 27/465 (5%) Query: 28 SRYEHIPGPPR---PSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTS 84 +R PG P P G +P + L F+ + +G VVR+ + KT Sbjct: 10 TRAPAAPGAPELREPPVAGGGVPLLGHGWRLARDPL--AFMSQLRDHGDVVRIKLGPKTV 67 Query: 85 VIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLA 144 VT+PE ++ Y+ ++ +L E L G+ V+ N +QRR I A Sbjct: 68 YAVTNPELTGALALNPDYHIAGPLWESL-----EGLLGKEGVATANGPLHRRQRRTIQPA 122 Query: 145 FSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSML 204 F ++ + E+A L E + V A+ + A+ + Sbjct: 123 FRLDAIPAYGPIMEEEAHALTERWQP----GKTVDATSESFRVAVRVAARCLL--RGQYM 176 Query: 205 LGAQKPLSQAVKLMLEGITA-SRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRRE 263 + L A+ + G+ L R +++ L + + + RR Sbjct: 177 DERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALADLHLLVDEIIAERRA 236 Query: 264 ALKRGEEVPADILTQILKAEEGAQD---DEGLLDNFVTFFIAGHETSANHLAFTVMELSR 320 + ++ P D+LT +L+A++ D ++ + D V G ET A+ + + + L+ Sbjct: 237 SGQK----PDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALAD 292 Query: 321 QPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLI 380 PE R++ EV+ V G R + FED+ +L++ V+ E++RL P W R E+ + Sbjct: 293 HPEHADRIRDEVEAVTGG-RPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESEL 351 Query: 381 DGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPK--PRFTYFPFSLGHRSCI 438 G R+P +++S Y + R ++D L F+PDR+ P P++ PFS G R C Sbjct: 352 GGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCP 411 Query: 439 GQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPVL 483 F+ ++ ++ A L + F V G ++ TL+P D ++ Sbjct: 412 SDHFSMAQLTLITAALATKYRFEQVAGSNDAVRVGITLRPHDLLV 456 >6IQ5-A nrPDB Length = 463 Score = 282 bits (720), Expect = 3e-76, Method: Composition-based stats. Identities = 99/465 (21%), Positives = 179/465 (38%), Gaps = 44/465 (9%) Query: 58 RVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNK-DSKMYRALQTVF 116 + F A++YG V ++ + V++ ++ + L+ D + + + V Sbjct: 1 QAAHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPSFASFRVVS 60 Query: 117 GERLFGQGLVSECNYERWHKQRRVIDLAFS------RSSLVSLMETFNEKAEQLVEILEA 170 G R G S E W QRR S L +A +LV +L Sbjct: 61 GGRSMAFGHYS----EHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALLVR 116 Query: 171 KADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLE--GITASRNT 228 + + + + ++++ FG S P + + E G T + Sbjct: 117 GSADGAFLDPRPLTVVAVANVMSAVCFGCRYSH----DDPEFRELLSHNEEFGRTVGAGS 172 Query: 229 LAKFLPGKRKQLREVRESIRFLRQVGRDWVQ-------RRREALKRGEEVPADILTQ-IL 280 L +P + VR R Q+ R++ R E+L+ G P D++ IL Sbjct: 173 LVDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPG-AAPRDMMDAFIL 231 Query: 281 KAEEGAQDD----------EGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQA 330 AE+ A D E + F A +T + L + ++ +R P++ R+QA Sbjct: 232 SAEKKAAGDSHGGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQA 291 Query: 331 EVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWG-TFRLLEEETLIDGVRVPGNT 389 E+D+V+G R D L Y+ L E++R T + G +P +T Sbjct: 292 ELDQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDT 351 Query: 390 PLLFSTYVMGRMDTYFEDPLTFNPDRFGPG----APKPRFTYFPFSLGHRSCIGQQFAQM 445 + + + + + +P F+P RF FS+G R CIG++ ++M Sbjct: 352 VVFVNQWSVNHDPVKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKM 411 Query: 446 EVKVVMAKLLQRLEFRLVPGQ--RFGLQEQATLKPLD-PVLCTLR 487 ++ + ++ L + +FR P + + T+KP V TLR Sbjct: 412 QLFLFISILAHQCDFRANPNEPAKMNFSYGLTIKPKSFKVNVTLR 456 >6C94-A nrPDB Length = 497 Score = 281 bits (718), Expect = 6e-76, Method: Composition-based stats. Identities = 118/477 (24%), Positives = 196/477 (41%), Gaps = 31/477 (6%) Query: 31 EHIPGPPRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKT-SVIVTS 89 + PGPP +L F E+ D + W +++ + V + + Sbjct: 22 DSFPGPPT-HWL------FGHALEIQKTGSLDKVVTWTQQFPYAHPLWVGQFIGFLNIYE 74 Query: 90 PESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSS 149 P+ K F + G+GL+ + +W + R+++ F Sbjct: 75 PDYAKAVY------SRGDPKAPDVYDFFLQWIGKGLLVL-DGPKWFQHRKLLTPGFHYDV 127 Query: 150 LVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQK 209 L + F + ++E E KA + + + A+D L K FG S L Sbjct: 128 LKPYVAIFADSTRIMLEKWEKKACEGKSFDIFSDVGHMALDTLMKCTFGKGDSGLNHRDS 187 Query: 210 PLSQAVK---LMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALK 266 AV L+++ S F+ R + R +++R+ AL+ Sbjct: 188 SYYVAVSELTLLMQQRIDSFQYHNDFIYWLTPHGRRFLRACRAAHDHTDRVIRQRKAALQ 247 Query: 267 RGEEVPA-------DILTQIL--KAEEGAQ-DDEGLLDNFVTFFIAGHETSANHLAFTVM 316 +E D L +L + E G Q D L TF GH+T+ + +++ + Sbjct: 248 DEKEREKIQNRRHLDFLDILLDVRGESGVQLSDTDLRAEVDTFMFEGHDTTTSGISWFLY 307 Query: 317 ELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEE 376 ++ PE R + EV E++G + +EDL ++ YL+ +KE RLYPP +R L + Sbjct: 308 CMALYPEHQQRCREEVREILGDQDSFQWEDLAKMTYLTMCMKECFRLYPPVPQVYRQLSK 367 Query: 377 ETL-IDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPR--FTYFPFSLG 433 +DG +P + + Y + R + DP F+P RF P R + + PFS G Sbjct: 368 PVSFVDGRSLPAGSLISLHIYALHRNSDVWPDPEVFDPLRFSPENSSGRHPYAFIPFSAG 427 Query: 434 HRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPVLCTLRPRG 490 R+CIGQQFA E+KVV A L R EF + P + Q L+ + + L+P G Sbjct: 428 PRNCIGQQFAMNEMKVVTALCLLRFEFSVDPLRLPIKLPQLVLRSKNGIHLYLKPLG 484 >2VE3-A nrPDB Length = 444 Score = 280 bits (716), Expect = 1e-75, Method: Composition-based stats. Identities = 103/457 (22%), Positives = 186/457 (40%), Gaps = 32/457 (7%) Query: 33 IPGPPRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPES 92 IP LG F + G + +++GP+ + +F K + ++ Sbjct: 13 IPPGDFGLPWLGETLNFLNDGDFGKKR--------QQQFGPIFKTRLFGKNVIFISG-AL 63 Query: 93 VKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVS 152 +FL + K+ + ++A + L G ++ E +R+++ AF +L S Sbjct: 64 ANRFL----FTKEQETFQATWPLSTRILLGPNALATQMGEIHRSRRKILYQAFLPRTLDS 119 Query: 153 LMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLS 212 + + + +E V L D+ A G + S L Sbjct: 120 YLPKMDGIVQGYLEQWGK----ANEVIWYPQLRRMTFDVAATLFMGEKVSQ----NPQLF 171 Query: 213 QAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVP 272 + ++G+ + L L GK ++ R + + + + + R+ EE Sbjct: 172 PWFETYIQGLFSLPIPLPNTLFGKSQRARALLLA-------ELEKIIKARQQQPPSEEDA 224 Query: 273 ADILTQILKAEEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEV 332 IL L D + AGHET + L+ + L + +I R++ E Sbjct: 225 LGILLAARDDNNQPLSLPELKDQILLLLFAGHETLTSALSSFCLLLGQHSDIRERVRQEQ 284 Query: 333 DEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLL 392 +++ S+ L E L ++ YL QVL+E LRL PP G FR L ++ G P + Sbjct: 285 NKLQLSQ-ELTAETLKKMPYLDQVLQEVLRLIPPVGGGFRELIQDCQFQGFHFPKGWLVS 343 Query: 393 FSTYVMGRMDTYFEDPLTFNPDRFGPGAP---KPRFTYFPFSLGHRSCIGQQFAQMEVKV 449 + + DP F+P+RF P P F + PF G R C+G++FA++E+K+ Sbjct: 344 YQISQTHADPDLYPDPEKFDPERFTPDGSATHNPPFAHVPFGGGLRECLGKEFARLEMKL 403 Query: 450 VMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPVLCTL 486 +L+Q+ ++ L+PGQ L + +P D + L Sbjct: 404 FATRLIQQFDWTLLPGQNLELVVTPSPRPKDNLRVKL 440 >3TBG-A nrPDB Length = 479 Score = 269 bits (687), Expect = 2e-72, Method: Composition-based stats. Identities = 92/444 (20%), Positives = 165/444 (37%), Gaps = 22/444 (4%) Query: 64 FLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQ 123 F +++G V + + V++ +V++ L++ + + + + G Q Sbjct: 36 FDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQ 95 Query: 124 GLVSECNYERWHKQRRVIDLAFSRSSL--VSLMETFNEKAEQLVEILEAKADGQTPVSMQ 181 G+ W +QRR L SL + E+A L P Sbjct: 96 GVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFAN--HSGRPFRPN 153 Query: 182 DMLTYTAMDIL----AKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKR 237 +L +++ F + L + +K + N + L Sbjct: 154 GLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPA 213 Query: 238 KQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQ-------DDE 290 + +R FL Q+ + + R + P D+ L E A+ +DE Sbjct: 214 LAGKVLRFQKAFLTQL-DELLTEHRMTWDPAQ-PPRDLTEAFLAEMEKAKGNPESSFNDE 271 Query: 291 GLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRL 350 L F AG T++ LA+ ++ + P++ R+Q E+D+VIG R + D + Sbjct: 272 NLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHM 331 Query: 351 QYLSQVLKESLRLYPPAW-GTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPL 409 Y + V+ E R G + + + G R+P T L+ + + + + +E P Sbjct: 332 PYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPF 391 Query: 410 TFNPDRF--GPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQR 467 F+P+ F G + PFS G R+C+G+ A+ME+ + LLQ F + GQ Sbjct: 392 RFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQP 451 Query: 468 FGLQEQ--ATLKPLDPVLCTLRPR 489 A L P PR Sbjct: 452 RPSHHGVFAFLVSPSPYELCAVPR 475 >3S79-A nrPDB Length = 503 Score = 263 bits (673), Expect = 1e-70, Method: Composition-based stats. Identities = 94/472 (19%), Positives = 187/472 (39%), Gaps = 28/472 (5%) Query: 31 EHIPGPPRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSP 90 IPGP +G L + +G + + + YG +RV + + ++I++ Sbjct: 45 SSIPGP-GYCMGIGPLISHGRFLWMGIGSACNY---YNRVYGEFMRVWISGEETLIISKS 100 Query: 91 ESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSL 150 S+ + Y+ LQ + + +G++ N E W R A S L Sbjct: 101 SSMFHIMKHNHYSSRFGSKLGLQCI---GMHEKGIIFNNNPELWKTTRPFFMKALSGPGL 157 Query: 151 VSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSM---LLGA 207 V ++ E + ++ LE + V + +L +D + ++ Sbjct: 158 VRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKI 217 Query: 208 QKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKR 267 Q L+++ ++ K +++++++I L +RRR + + Sbjct: 218 QGYFDAWQALLIK--PDIFFKISWLYKKYEKSVKDLKDAIEVLIAE-----KRRRISTEE 270 Query: 268 GEEVPADILTQILKAEE-GAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVA 326 E D T+++ AE+ G E + + IA +T + L F + +++ P + Sbjct: 271 KLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEE 330 Query: 327 RLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVP 386 + E+ VIG +R + +D+ +L+ + + ES+R P R E+ +IDG V Sbjct: 331 AIIKEIQTVIG-ERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVK 389 Query: 387 GNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQME 446 T ++ + M R++ +F P F + F P + PF G R C G+ A + Sbjct: 390 KGTNIILNIGRMHRLE-FFPKPNEFTLENFAKNV--PYRYFQPFGFGPRGCAGKYIAMVM 446 Query: 447 VKVVMAKLLQRLEFRLVPGQ---RFGLQEQATLKPLDP---VLCTLRPRGWQ 492 +K ++ LL+R + + GQ +L P + + PR Sbjct: 447 MKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLHPDETKNMLEMIFTPRNSD 498 >4ZGX-A nrPDB Length = 489 Score = 254 bits (648), Expect = 8e-68, Method: Composition-based stats. Identities = 104/476 (21%), Positives = 181/476 (38%), Gaps = 23/476 (4%) Query: 30 YEHIPGPPRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTS 89 +E +P P +L L W+ E G L ++ GP+ R N+ V V Sbjct: 15 FEAMPQHPGNRWLR--LLQIWR--EQGYEHLHLEMHQTFQELGPIFRYNLGGPRMVCVML 70 Query: 90 PESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQR-RVIDLAFSRS 148 PE V+K L +M + + + V N W R R+ S Sbjct: 71 PEDVEK-LQQVDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPK 129 Query: 149 SLVSLMETFNEKAEQLVEILEAK----ADGQTPVSMQDMLTYTAMDILAKAAFGMETSML 204 ++ + + A + L+ K A G + +Q + + ++ A FG ++ Sbjct: 130 AVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLV 189 Query: 205 LGAQKPLSQAVKLMLEGITASRNTLAKFLPGKR------KQLREVRESIRFLRQVGRDWV 258 + S LE + S L F+P K +E E+ + Q G + + Sbjct: 190 GHSPSSASLNFLHALEVMFKSTVQLM-FMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCI 248 Query: 259 QRRREAL--KRGEEVPADILTQILKAEEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVM 316 Q+ + L R + + +LKAE E + N + +T+A L T+ Sbjct: 249 QKIYQELAFNRPQHYTGIVAELLLKAE---LSLEAIKANSMELTAGSVDTTAFPLLMTLF 305 Query: 317 ELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEE 376 EL+R P++ L+ E S + L L LKE+LRLYP R++ Sbjct: 306 ELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSS 365 Query: 377 ETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPK-PRFTYFPFSLGHR 435 + ++ +P T + Y +GR F P +NP R+ F + PF G R Sbjct: 366 DLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMR 425 Query: 436 SCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPVLCTLRPRGW 491 C+G++ A+ E+ +++ +L+ + + + L+P L T R Sbjct: 426 QCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILRPGTSPLLTFRAING 481 >6M7X-A nrPDB Length = 484 Score = 246 bits (629), Expect = 1e-65, Method: Composition-based stats. Identities = 101/472 (21%), Positives = 182/472 (38%), Gaps = 23/472 (4%) Query: 30 YEHIPGPPRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTS 89 +E +P P +L L W+ E G L ++ GP+ R ++ V V Sbjct: 15 FEAMPRRPGNRWLR--LLQIWR--EQGYEDLHLEVHQTFQELGPIFRYDLGGAGMVCVML 70 Query: 90 PESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQR-RVIDLAFSRS 148 PE V+K L +M + + + V N W R R+ S + Sbjct: 71 PEDVEK-LQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPN 129 Query: 149 SLVSLMETFNEKAEQLVEILEAK----ADGQTPVSMQDMLTYTAMDILAKAAFGMETSML 204 ++ + + A + L+ K A G + +Q + + ++ A FG ++ Sbjct: 130 AVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLV 189 Query: 205 LGAQKPLSQAVKLMLEGITASRNTLAKFLP------GKRKQLREVRESIRFLRQVGRDWV 258 + S LE + S L F+P K +E E+ + Q G + + Sbjct: 190 GHSPSSASLNFLHALEVMFKSTVQLM-FMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCI 248 Query: 259 QRRREAL--KRGEEVPADILTQILKAEEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVM 316 Q+ + L R ++ + + +L AE + + N + +T+ L T+ Sbjct: 249 QKIYQELAFSRPQQYTSIVAELLLNAE---LSPDAIKANSMELTAGSVDTTVFPLLMTLF 305 Query: 317 ELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEE 376 EL+R P + L+ E S + L L LKE+LRLYP R+ Sbjct: 306 ELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASS 365 Query: 377 ETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPK-PRFTYFPFSLGHR 435 + ++ +P T + Y +GR F P +NP R+ F + PF G R Sbjct: 366 DLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMR 425 Query: 436 SCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPVLCTLR 487 C+G++ A+ E+ +++ +L+ L+ + + + L+P L T R Sbjct: 426 QCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSMFPLLTFR 477 >3EJB-B nrPDB Length = 404 Score = 246 bits (629), Expect = 1e-65, Method: Composition-based stats. Identities = 66/416 (15%), Positives = 141/416 (33%), Gaps = 49/416 (11%) Query: 73 PVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYE 132 P+ + + VT E L ++ + + + ++ N Sbjct: 27 PIYKGSFLKYPGWYVTGYEETAAILKDARFKVRTPLPESSTKYQDLSHVQNQMMLFQNQP 86 Query: 133 RWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDIL 192 + R + AF+ + S E L++ ++ G+ + + + + Sbjct: 87 DHRRLRTLASGAFTPRTTESYQPYIIETVHHLLDQVQ----GKKKMEVISDFAFPLASFV 142 Query: 193 AKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQ 252 G+ ++ + ++ + RK L E Sbjct: 143 IANIIGVPEEDREQLKEWAASLIQTID-------------FTRSRKALTEGNIMAVQAMA 189 Query: 253 VGRDWVQRRREALKRGEEVPADILTQILKA-EEGAQDDEGLLDNFVTFFIAGHETSANHL 311 ++ +Q+R+ D+++ +LK E+ +E + IAGHET+ N + Sbjct: 190 YFKELIQKRK------RHPQQDMISMLLKGREKDKLTEEEAASTCILLAIAGHETTVNLI 243 Query: 312 AFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTF 371 + +V+ L + PE + +L+ D + ++E LR P T Sbjct: 244 SNSVLCLLQHPEQLLKLRENPD------------------LIGTAVEECLRYESPTQMTA 285 Query: 372 RLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFS 431 R+ E+ I GV + + R + F +P F+ R + F Sbjct: 286 RVASEDIDICGVTIRQGEQVYLLLGAANRDPSIFTNPDVFDITRSPN-------PHLSFG 338 Query: 432 LGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPVLCTLR 487 GH C+G A++E ++ + LLQR+ + + + + L+ + T Sbjct: 339 HGHHVCLGSSLARLEAQIAINTLLQRMPSLNLADFEWRYRPLFGFRALEELPVTFE 394 >5VWS-A nrPDB Length = 393 Score = 241 bits (616), Expect = 4e-64, Method: Composition-based stats. Identities = 73/388 (18%), Positives = 140/388 (36%), Gaps = 57/388 (14%) Query: 73 PVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYE 132 PV R V + V++ L + + + + FG+G ++ + Sbjct: 32 PVWRDQFG---IYHVFRYDDVRQILGD----YQTFSSDRTRLMPTAQGFGKGGITMIDPP 84 Query: 133 RWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDIL 192 QRR+I AF+ S+ ++ + A+ L++ L + + Y I+ Sbjct: 85 EHRHQRRLITHAFTPQSISAMEPRIRQIADHLLDELP-----GPEFDLVEHFAYPLPVIV 139 Query: 193 AKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQ 252 G+ + + + L +E + R V ++ + Sbjct: 140 IAELLGVPPGDRHLFRTWSDRLMSLQVENYADP------------ELARTVAAAMTEMND 187 Query: 253 VGRDWVQRRREALKRGEEVPADILTQILKAEEGAQ--DDEGLLDNFVTFFIAGHETSANH 310 R+ + RR D+LT++++AE + D E +++ +AGH T+ Sbjct: 188 YLREHCRSRRTH------PRDDLLTRLVQAEVEGKRLDLEEVVNTASLLLLAGHLTTTVL 241 Query: 311 LAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGT 370 + T++ L PE ++A+ + L+ESLRL P Sbjct: 242 IGNTMLCLWDHPEAEKAVRADP------------------SLIPAALEESLRLRSPFLQA 283 Query: 371 FRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPF 430 R+ + I G +P N ++ D F DP F+ R G + F Sbjct: 284 GRVTTRDVTIAGETIPANRFVMAWILSANHDDRRFPDPERFDLHRQTTG-------HIAF 336 Query: 431 SLGHRSCIGQQFAQMEVKVVMAKLLQRL 458 G C+G Q ++E ++ + +LL R Sbjct: 337 GHGVHFCLGAQLGRLEGRIALERLLGRF 364 >5NWS-A nrPDB Length = 435 Score = 240 bits (612), Expect = 1e-63, Method: Composition-based stats. Identities = 73/438 (16%), Positives = 148/438 (33%), Gaps = 68/438 (15%) Query: 55 VGGRVLQDVFLDWAK--KYGPVVRVNVF-HKTSVIVTSPESVKKFLMSTKY--------- 102 + +L D F + + + GPVVR VT + V+ L ++ Sbjct: 28 MDPDLLADPFTGYGRLRERGPVVRGRFVDGTPVWFVTRYDDVRAVLRDPRFVNTPSPVPG 87 Query: 103 ----NKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFN 158 + M L R++ G + + + + RR++ AF+ ++ L Sbjct: 88 EGGADPREGMMDLLNVPEPLRVYLLGSILDSDPPDHPRLRRLVTRAFAARRILGLRPGIE 147 Query: 159 EKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLM 218 A++L+ L + + V + + Y + G+ + L ++ V + Sbjct: 148 RIADRLLAELPRREEEDGTVDLLEHFAYPLSITVICELVGIPATDLERWREWGGDLVSM- 206 Query: 219 LEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQ 278 + +R S + +++RR AL D+L++ Sbjct: 207 --------------------RPERLRHSFPVMIDYCHRLIEQRRAAL------TDDLLSE 240 Query: 279 ILKAEE---GAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEV 335 +++A++ G D + +T +AGHETSA+ + L P A L+ + Sbjct: 241 LIRAQDDDGGRLSDIETVTMILTLVLAGHETSAHLIGNGTAALLTHPGQWALLRKDPA-- 298 Query: 336 IGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTF-RLLEEETLIDGVRVPGNTPLLFS 394 L + + E +R R E+ + G V + Sbjct: 299 ----------------LLPRAVHELMRWCGSVHVARLRYATEDLELAGTPVARGDAVQLV 342 Query: 395 TYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKL 454 ++ DP + R G + + F G C+G A+ E +V +A+L Sbjct: 343 LVSANFDPRHYSDPDRLDITRHQEGQAE---NHVGFGHGIHYCLGATLARQEGEVALARL 399 Query: 455 LQRLEFRLVPGQRFGLQE 472 L+ + ++ Sbjct: 400 LETYPDLALADGDPEVRR 417 >2W0A-A nrPDB Length = 455 Score = 237 bits (605), Expect = 7e-63, Method: Composition-based stats. Identities = 92/437 (21%), Positives = 173/437 (39%), Gaps = 30/437 (6%) Query: 33 IPGPPRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPES 92 +P GHL F + D +G + G V + K V+++ + Sbjct: 6 LPRVSGGHDEHGHLEEF-RTDPIGL------MQRVRDELGDVGTFQLAGKQVVLLSGSHA 58 Query: 93 VKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVS 152 + F + + D +A F +FG+ +V + + ER + + + A + Sbjct: 59 NEFFFRAGDDDLD----QAKAYPFMTPIFGEAVVFDASPERRKEM--LHNAALRGEQMKG 112 Query: 153 LMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLS 212 T ++ +++ + + D + + G + L + + Sbjct: 113 HAATIEDQVRRMIADWGE----AGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGR--FA 166 Query: 213 QAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVP 272 + + G + R E+ L + D + R ++ Sbjct: 167 KLYHELERGTDPLAYVDPYL---PIESFRRRDEARNGLVALVADIMNGRIAN-PPTDKSD 222 Query: 273 ADILTQIL--KAEEGAQ--DDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARL 328 D+L ++ KAE G + + F++ AGH TS+ ++T++EL R + A + Sbjct: 223 RDMLDVLIAVKAETGTPRFSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAV 282 Query: 329 QAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGN 388 E+DE+ G R + F L ++ L VLKE+LRL+PP R+ + E + G R+ Sbjct: 283 IDELDELYGDGRSVSFHALRQIPQLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEG 342 Query: 389 TPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKP---RFTYFPFSLGHRSCIGQQFAQM 445 + S + R+ F DP F P R+ + R+T+ PF G C+G FA M Sbjct: 343 DLVAASPAISNRIPEDFPDPHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIM 402 Query: 446 EVKVVMAKLLQRLEFRL 462 ++K + + LL+ EF + Sbjct: 403 QIKAIFSVLLREYEFEM 419 >2Y5N-A nrPDB Length = 417 Score = 237 bits (604), Expect = 9e-63, Method: Composition-based stats. Identities = 99/462 (21%), Positives = 170/462 (36%), Gaps = 76/462 (16%) Query: 37 PRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYG------PVVRVNVF-HKTSVIVTS 89 PR S + P + ++V G L A +YG PV RV + + +VT Sbjct: 16 PRGSHMTSAEPRAYPFNDVHG-------LTLAGRYGELQETEPVSRVRPPYGEEAWLVTR 68 Query: 90 PESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSS 149 E V+ L ++ + M R E + +G + + + RR++ AF+ Sbjct: 69 YEDVRAVLGDGRFVRGPSMTRDEPRTRPEMV--KGGLLSMDPPEHSRLRRLVVKAFTARR 126 Query: 150 LVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTY-TAMDILAKAAFGMETSMLLGAQ 208 SL E A +LV+ + A P + M + ++ LLG Sbjct: 127 AESLRPRAREIAHELVDQMAATGQ---PADLVAMFARQLPVRVIC---------ELLGVP 174 Query: 209 KPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRG 268 FL E++E+ D + RRR+ Sbjct: 175 SADHDRFTRWS----------GAFLSTAEVTAEEMQEAAEQAYAYMGDLIDRRRK----- 219 Query: 269 EEVPADILTQILKAEE--GAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVA 326 E D+++ +++A + + ++ LLD + +AG+E++ +A V L +PE+ Sbjct: 220 -EPTDDLVSALVQARDQQDSLSEQELLDLAIGLLVAGYESTTTQIADFVYLLMTRPELRR 278 Query: 327 RLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGT--FRLLEEETLIDGVR 384 +L L R + + ++E R P GT R E+ + GV Sbjct: 279 QL------------------LDRPELIPSAVEELTRWVPLGVGTAFPRYAVEDVTLRGVT 320 Query: 385 VPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQ 444 + P+L ST R F D + DR + F G C+G A+ Sbjct: 321 IRAGEPVLASTGAANRDQAQFPDADRIDVDRTPNQ-------HLGFGHGVHHCLGAPLAR 373 Query: 445 MEVKVVMAKLLQRLE-FRL-VPGQRFGLQEQATLKPLDPVLC 484 +E++V + LLQRL RL +P + E L+ + Sbjct: 374 VELQVALEVLLQRLPGIRLGIPETQLRWSEGMLLRGPLELPV 415 >5OFQ-A nrPDB Length = 409 Score = 235 bits (600), Expect = 3e-62, Method: Composition-based stats. Identities = 64/408 (15%), Positives = 145/408 (35%), Gaps = 57/408 (13%) Query: 81 HKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRV 140 + V E+VK L + + Q + + + K R + Sbjct: 48 SRNCWDVFDYETVKYILKNPSLFSSKRAMEERQE----------SILMMDPPKHTKLRNL 97 Query: 141 IDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGME 200 ++ AF+ ++ L E A+ L++ + +K + + I+ G+ Sbjct: 98 VNKAFTPRAIQHLEGHIEEIADYLLDEVSSKEK----FDIVEDFAGPLPIIVIAELLGVP 153 Query: 201 TSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQR 260 + + ++ G + + K +++ E + FL+ ++ + Sbjct: 154 IQ----DRALFKKYSDDLVSGAENNSDEAF------AKMMQKRNEGVIFLQGYFKEIIAE 203 Query: 261 RREALKRGEEVPADILTQILKAEEGAQ--DDEGLLDNFVTFFIAGHETSANHLAFTVMEL 318 R++ + D+++ +L+AE + +E +L + +AG+ET+ N + V + Sbjct: 204 RQQNKQ------EDLISLLLEAEIDGEHLTEEEVLGFCILLLVAGNETTTNLITNGVRYM 257 Query: 319 SRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEET 378 + ++ ++ ++ + +++E+LR YPP R+ E+ Sbjct: 258 TEDVDVQNEVRRDI------------------SLVPNLVEETLRYYPPIQAIGRIAAEDV 299 Query: 379 LIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCI 438 + ++ ++ R FE P TF R + F G C+ Sbjct: 300 ELGECKIKRGQQVISWAASANRDSAKFEWPDTFVVHR-------KTNPHVSFGFGIHFCL 352 Query: 439 GQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPVLCTL 486 G A+ME K+ KLL++ F V Q + + + Sbjct: 353 GAPLARMEGKIAFTKLLEKGGFSKVQNQSLKPIDSPFVFGVKKYEIAF 400 >5L94-A nrPDB Length = 410 Score = 235 bits (599), Expect = 3e-62, Method: Composition-based stats. Identities = 69/407 (16%), Positives = 148/407 (36%), Gaps = 60/407 (14%) Query: 82 KTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQG-LVSECNYERWHKQRRV 140 + V + VK+ L + + +R G + + + + R + Sbjct: 44 RQVWDVFHYDGVKEVLEQKNIFSSDR-----RPPQNQRQTALGTSLINIDPPKHAEMRAL 98 Query: 141 IDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGME 200 ++ AF+ ++ + +L++ +E D + + + L+Y ++ G+ Sbjct: 99 VNKAFTPKAMKAWEPKIARITNELLQEVEHLED----IDIVEHLSYPLPVMVIADILGVP 154 Query: 201 TSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQR 260 Q+ +++ G + + K +E ++ L ++ Sbjct: 155 IE----DQRQFKDWSDIIVAGPSNNERE------TLEKLQQEKMKANDELETYFYRIIEE 204 Query: 261 RREALKRGEEVPADILTQILKAEEGAQ--DDEGLLDNFVTFFIAGHETSANHLAFTVMEL 318 +R DI++ +L+A+E + DE ++ + IAG+ET+ N ++ T+ L Sbjct: 205 KR------TRPGDDIISVLLQAKEEGKQLTDEEIVGFSILLLIAGNETTTNLISNTIYCL 258 Query: 319 SRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEET 378 RL+ E + L ++E LR P R+++E+ Sbjct: 259 MEDKASFERLKRE------------------KELLPSGIEEVLRYRSPVQALHRIVKEDV 300 Query: 379 LIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCI 438 + G ++ ++ R YFEDP F DR + F G C+ Sbjct: 301 TLAGKKLKAGEHVVPWMGSAHRDAEYFEDPEVFKIDR-------KPNVHMAFGRGIHFCL 353 Query: 439 GQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPVLCT 485 G A++E K+++A+L+ R + LKP++ Sbjct: 354 GAPLARIEAKIMLAELIDRYP-------QMDWSPSFELKPIESTFVY 393 >4UBS-A nrPDB Length = 393 Score = 227 bits (579), Expect = 7e-60, Method: Composition-based stats. Identities = 82/424 (19%), Positives = 160/424 (37%), Gaps = 62/424 (14%) Query: 73 PVVRVNVF-HKTSVIVTSPESVKKFLMSTKYNKDS--KMYRALQTVFGERLFGQGLVSEC 129 P+ RV+++ ++ +VT + + L + + D + A F + + Sbjct: 27 PLSRVSLYDGRSVWVVTGHAAARALLSDQRLSSDRTLPRFPATTERFEAVRTRRVALLGV 86 Query: 130 NYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAM 189 + QRR++ +F+ +L E + L++ +EA+ P + Sbjct: 87 DDPEHRTQRRMLVPSFTLKRAAALRPRIQETVDGLLDAMEAQG---PPAELVSAFALPLP 143 Query: 190 DILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRF 249 ++ A G+ + + + ++ + EV+++ Sbjct: 144 SMVICALLGVPYADHDFFESQSRRLLRG--------------------PGIAEVQDARAQ 183 Query: 250 LRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDEGLLDNFVTFFIAGHETSAN 309 L + R+R+ + G+ + D++ + L G D L+ IAGHET+AN Sbjct: 184 LDDYLYALIDRKRK--EPGDGLLDDLIQEQLN--RGTVDRAELVSLATLLLIAGHETTAN 239 Query: 310 HLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWG 369 ++ L R PE +A L+AE + ++E LR A G Sbjct: 240 MISLGTFTLLRHPEQLAELRAEPG------------------LMPAAVEELLRFLSIADG 281 Query: 370 TFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFP 429 R+ E+ + G + + ++F+T V+ R F +P + R + Sbjct: 282 LLRVATEDIEVAGTTIRADEGVVFATSVINRDAAGFAEPDALDWHR-------SARHHVA 334 Query: 430 FSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQ-EQATLKPLDPVLCTLR- 487 F G C+GQ A+ E+++ + L +RL PG R ++ KP D + L Sbjct: 335 FGFGIHQCLGQNLARAEMEIALGTLFERL-----PGLRLAAPADEIPFKPGDTIQGMLEL 389 Query: 488 PRGW 491 P W Sbjct: 390 PVTW 393 >2VZM-A nrPDB Length = 436 Score = 227 bits (578), Expect = 1e-59, Method: Composition-based stats. Identities = 85/473 (17%), Positives = 161/473 (34%), Gaps = 75/473 (15%) Query: 24 HRARSRYEHIPGPPRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVF-HK 82 H R++ PP + + + + GP RV Sbjct: 20 HMRRTQQGTTASPP--------VLDLGALGQDFAADPYPTYARLRAE-GPAHRVRTPEGN 70 Query: 83 TSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGL-VSECNYERWHKQRRVI 141 +V + + L +++KD +R T E + E + R + R+++ Sbjct: 71 EVWLVVGYDRARAVLADPRFSKD---WRNSTTPLTEAEAALNHNMLESDPPRHTRLRKLV 127 Query: 142 DLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMET 201 F+ + L E + LV+ + A DG+ + + L + + Sbjct: 128 AREFTMRRVELLRPRVQEIVDGLVDAMLAAPDGRA--DLMESLAWPLPITV--------I 177 Query: 202 SMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRR 261 S LLG +P A ++ + + + + ++ + + + Sbjct: 178 SELLGVPEPDRAAFRVWTDAFVFPDDPA------------QAQTAMAEMSGYLSRLIDSK 225 Query: 262 REALKRGEEVPADILTQILKAEEGA---QDDEGLLDNFVTFFIAGHETSANHLAFTVMEL 318 R + D+L+ +++ + E LL +AGHET+ N +A + L Sbjct: 226 R------GQDGEDLLSALVRTSDEDGSRLTSEELLGMAHILLVAGHETTVNLIANGMYAL 279 Query: 319 SRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPA-WGTFRLLEEE 377 P+ +A L+A+ + L ++E LR P T+R E Sbjct: 280 LSHPDQLAALRAD------------------MTLLDGAVEEMLRYEGPVESATYRFPVEP 321 Query: 378 TLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSC 437 +DG +P +L R F DP F+ R G + F G C Sbjct: 322 VDLDGTVIPAGDTVLVVLADAHRTPERFPDPHRFDIRRDTAG-------HLAFGHGIHFC 374 Query: 438 IGQQFAQMEVKVVMAKLLQR---LEFRLVPGQRFGLQEQATLKPLDPVLCTLR 487 IG A++E ++ + LL+R L + PG+ ++ L + R Sbjct: 375 IGAPLARLEARIAVRALLERCPDLALDVSPGE-LVWYPNPMIRGLKALPIRWR 426 >5CJE-A nrPDB Length = 393 Score = 225 bits (574), Expect = 3e-59, Method: Composition-based stats. Identities = 77/451 (17%), Positives = 149/451 (33%), Gaps = 67/451 (14%) Query: 43 LGHLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTS---VIVTSPESVKKFLMS 99 +G++ + V+ + ++ GPV V + +V E + L Sbjct: 1 MGNVIDLGEYGARFTEDPYPVYAELRER-GPVHWVRTPPPEAFEGWLVVGHEEARAALAD 59 Query: 100 TKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNE 159 + +KD + L ++ E + LV + + R ++ AF+ + +L E Sbjct: 60 PRLSKDG-TKKGLTSLDVELMGPYLLVV--DPPEHTRLRSLVARAFTMRRVEALRPRIQE 116 Query: 160 KAEQLVEILEAKADGQTPVSMQDMLTYT-AMDILAKAAFGMETSMLLGAQKPLSQAVKLM 218 + L++ + + + D Y + ++ LLG + + Sbjct: 117 ITDGLLDEMLPRGRA----DLVDSFAYPLPITVIC---------ELLGVPDIDRVTFRAL 163 Query: 219 LEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQ 278 I A A+ + L + + KR D+L Sbjct: 164 SNEIVAPTGGDAEL------------AAYERLAAYLDELIDD-----KRSTAPADDLLGD 206 Query: 279 ILK---AEEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEV 335 +++ ++ E L +AGHET+ N + V L P+ +A L+A+ Sbjct: 207 LIRTRAEDDDRLSGEELRAMAFILLVAGHETTVNLITNGVHTLLTHPDQLAALRAD---- 262 Query: 336 IGSKRYLDFEDLGRLQYLSQVLKESLRLYPPA-WGTFRLLEEETLIDGVRVPGNTPLLFS 394 + L ++E LR P T+R E I G + P++ Sbjct: 263 --------------MTLLDGAVEEVLRFEGPVETATYRYAAESMEIGGTAIAEGDPVMIG 308 Query: 395 TYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKL 454 GR DP F+ R G + F G C+G A++E +V + L Sbjct: 309 LDAAGRDPARHPDPHVFDIHRAPQG-------HLAFGHGIHYCLGAPLARLEARVALRSL 361 Query: 455 LQRLEFRLVPGQRFGLQEQATLKPLDPVLCT 485 L+R + G ++ + + Sbjct: 362 LERCPDLALDGPPGARPPGMLIRGVRRLPVR 392 >4GGV-A nrPDB Length = 418 Score = 222 bits (566), Expect = 3e-58, Method: Composition-based stats. Identities = 83/457 (18%), Positives = 166/457 (36%), Gaps = 64/457 (14%) Query: 37 PRPSFLLGHLPCFWKKDE-----VGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPE 91 PR S ++ + W G R V D + V V + + I+ + Sbjct: 16 PRGSHMMTTVVDRWNIHPDHLWLRGQRPESPVVFDETQ---GVWNVYGYPEAMDILNDHD 72 Query: 92 SVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLV 151 + + L V + +G +S+ + R K R+++ AF+ + Sbjct: 73 T------------FTSDLAHLLPVSVDAPLLEGDMSQMDPPRHRKYRQLVSRAFTPRLVA 120 Query: 152 SLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPL 211 + + +L++ + DG+ + + L Y I+ G+ G + Sbjct: 121 DMETRVADITRELLDAV----DGKPEIEIAADLAYPLPVIVIAELLGVPA----GDRDLF 172 Query: 212 SQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEV 271 + ++EG + FL + ++VR++ LR + D++ +R Sbjct: 173 KKWADDIIEGFSG-----FSFLDTSGQGEQDVRDATERLRPLL-DYMAGHV--TERRRTP 224 Query: 272 PADILTQILKAEEGA--QDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQ 329 D+LT +++AE D +++ + GH T+ L TV+ L PE+ A+++ Sbjct: 225 REDLLTHLVQAEVDGERLTDNEIVNVANILLVTGHITTTMTLGNTVLCLDADPEVAAKVR 284 Query: 330 AEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNT 389 A+ V G ++E+LR+ P+ R E + G +P + Sbjct: 285 ADRSLVPG------------------AIEEALRVLSPSAALARGTSREVEVAGTVIPKDQ 326 Query: 390 PLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKV 449 ++ R F DP ++P R +F F G C+G A++E +V Sbjct: 327 IVMLWLGAGNRDPRQFTDPEVYDPTRDPN-------PHFGFGRGIHFCLGAPLARLEGRV 379 Query: 450 VMAKLLQRLE-FRLVPGQRFGLQEQATLKPLDPVLCT 485 + L R R P + + ++ + Sbjct: 380 ALNALFDRFPVLRTDPAKPPTFFPTPDMIGVNTLHLR 416 >4RM4-A nrPDB Length = 396 Score = 221 bits (564), Expect = 4e-58, Method: Composition-based stats. Identities = 58/379 (15%), Positives = 133/379 (35%), Gaps = 55/379 (14%) Query: 83 TSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVID 142 V + VKK + + + G ++ + + K R V++ Sbjct: 46 QVWSVFLYDDVKKVVGDKELFSSCMPQQ-------TSSIGNSII-NMDPPKHTKIRSVVN 97 Query: 143 LAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETS 202 AF+ + E ++L++ + G++ + +Y I+ G+ ++ Sbjct: 98 KAFTPRVMKQWEPRIQEITDELIQKFQ----GRSEFDLVHDFSYPLPVIVISELLGVPSA 153 Query: 203 MLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRR 262 + + K + + ++ ++ ++ L E + L ++ +R Sbjct: 154 HM--------EQFKAWSDLLVSTPKDKSEE--AEKAFLEERDKCEEELAAFFAGIIEEKR 203 Query: 263 EALKRGEEVPADILTQILKAEEGA--QDDEGLLDNFVTFFIAGHETSANHLAFTVMELSR 320 + DI++ +++AEE E L+ +AG+ET+ N ++ + + Sbjct: 204 ------NKPEQDIISILVEAEETGEKLSGEELIPFCTLLLVAGNETTTNLISNAMYSILE 257 Query: 321 QPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLI 380 P + L+ + + Q ++E+LR PA R+ + +T I Sbjct: 258 TPGVYEELR------------------SHPELMPQAVEEALRFRAPAPVLRRIAKRDTEI 299 Query: 381 DGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQ 440 G + +L R + F+ P F+ R + F G C+G Sbjct: 300 GGHLIKEGDMVLAFVASANRDEAKFDRPHMFDIRRHPN-------PHIAFGHGIHFCLGA 352 Query: 441 QFAQMEVKVVMAKLLQRLE 459 A++E + + L+ Sbjct: 353 PLARLEANIALTSLISAFP 371 >6GMF-A nrPDB Length = 397 Score = 220 bits (561), Expect = 9e-58, Method: Composition-based stats. Identities = 79/410 (19%), Positives = 139/410 (33%), Gaps = 51/410 (12%) Query: 78 NVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQ 137 + + + V + V + L K + +L + + + R K Sbjct: 31 RLQPQGFMAVGRYQDVARVLHDAKGFSNRGWAASLPRGVKWDTSMPPSIVQVDPPRHGKL 90 Query: 138 RRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAF 197 R ++ AF+ ++ L + A +LV+ L K+ + V +T I+ Sbjct: 91 RTLVTKAFTPRTVAQLEPRIRDIAHELVDGLRGKSTFEATV----EVTVPMPMIVIAEML 146 Query: 198 GMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDW 257 G+ +LA G QL + + Sbjct: 147 GVAPERR-----------ADFKRWSDDMVGSLALVRVGNAAQLERSTQEF---YAYFSEV 192 Query: 258 VQRRREALKRGEEVPADILTQILKAEEGA--QDDEGLLDNFVTFFIAGHETSANHLAFTV 315 + +R E D+++Q+L AE +L T IAG+ET+ + + + Sbjct: 193 L------EERRREPREDLISQLLAAEVDGEKLTAGEVLSFANTLLIAGNETTTSLIGNAL 246 Query: 316 MELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLE 375 + L+ PE +A QA+ L + V++E LR PA FR Sbjct: 247 VALTDHPEQLAAAQAD------------------LSLVPAVVEEVLRYESPAQCIFRQTM 288 Query: 376 EETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHR 435 + I R+P + +L R ++ F DP F+ R G + F L Sbjct: 289 TDVEIGDERIPARSVVLPLLASANRDESRFPDPDRFDIHRDTKG-------HLAFGLDIH 341 Query: 436 SCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPVLCT 485 CIG A++E KV++ LL RL Q ++ + Sbjct: 342 FCIGAPLARLEAKVMLEVLLARLGDIQRVSQEVSWSPSFFIRSPSTLPLR 391 >5IT1-A nrPDB Length = 399 Score = 218 bits (555), Expect = 4e-57, Method: Composition-based stats. Identities = 72/419 (17%), Positives = 143/419 (34%), Gaps = 59/419 (14%) Query: 73 PVVRVNV-FHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNY 131 PV R + +VT E V+ L ++ Q + G+G + + Sbjct: 33 PVTRATFTSGHEAWLVTGYEQVRAVLRDPSFSVGVPHALHTQDGVVTQKPGRGSLLWQDA 92 Query: 132 ERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDI 191 R+++ F+ + +L ++ ++ +EA+ PV + + Sbjct: 93 PEHTDDRKLLAKEFTVRRMQALRPNIQRIVDEHLDAIEARG---GPVDLVKTFANPVPSM 149 Query: 192 LAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLR 251 + FG+ Q+ +A+ + + + L Sbjct: 150 VISDLFGVPAERRAEFQE-------------------IAEAMMRVDQDAAATEAAGMRLG 190 Query: 252 QVGRDWVQRRREALKRGEEVPADILTQILKAEE--GAQDDEGLLDNFVTFFIAGHETSAN 309 + VQ RR D+++ ++ E+ G DD L++ T IA H+T+A Sbjct: 191 GLLYQLVQERRA------NPGDDLISALITTEDPDGVIDDMFLMNAAGTLLIAAHDTTAC 244 Query: 310 HLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPA-W 368 + L +P+ +A LQ + + ++E LR + Sbjct: 245 MIGLGTALLLDRPDQLALLQKDP------------------SLIGNAVEELLRYLTIGQF 286 Query: 369 GTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYF 428 G R+ ++ I GVR+ ++ + EDP F+ R + Sbjct: 287 GAERVATQDGEIGGVRIAKGEQVVTHLLSADFDPAFVEDPERFDITRRPA-------PHL 339 Query: 429 PFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLV--PGQRFGLQEQATLKPLDPVLCT 485 F G CIGQQ A++E+++V L +R + P + + + + T Sbjct: 340 AFGFGAHQCIGQQLARIELQIVFGTLFRRFPTLRLAKPVEELRFRNDMVFYGVHELPVT 398 >3A50-A nrPDB Length = 411 Score = 216 bits (551), Expect = 1e-56, Method: Composition-based stats. Identities = 73/424 (17%), Positives = 144/424 (33%), Gaps = 63/424 (14%) Query: 73 PVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYE 132 PV ++ + ++T V++ + + +KD + ++ + Sbjct: 34 PVRKLALPDGPVWLLTRYADVREAFVDPRLSKDWRHRLPEDQRADMPATPTPMMILMDPP 93 Query: 133 RWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDIL 192 + R+++ +F+ + L E A+ L+ L PV + + + Sbjct: 94 DHTRLRKLVGRSFTVRRMNELEPRITEIADGLLAGLPT----DGPVDLMREYAFQIPVQV 149 Query: 193 AKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQ 252 G+ + S ++++ A + ++ L Sbjct: 150 ICELLGLPAE----DRDDFSAWSSVLVDDSPAD----------------DKNAAMGKLHG 189 Query: 253 VGRDWVQRRREALKRGEEVPAD-ILTQILKAEEGAQDD---EGLLDNFVTFFIAGHETSA 308 D ++R+R P D +L+ +L + D E L+ + IAGHET+ Sbjct: 190 YLSDLLERKR-------TEPDDALLSSLLAVSDMDGDRLSQEELVAMAMLLLIAGHETTV 242 Query: 309 NHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPA- 367 N + V+ L P+ L + +S ++E LR P Sbjct: 243 NLIGNGVLALLTHPDQRKLLAEDP------------------SLISSAVEEFLRFDSPVS 284 Query: 368 WGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTY 427 R E+ GV +P ++ R + +P + R G Sbjct: 285 QAPIRFTAEDVTYSGVTIPAGEMVMLGLAAANRDADWMPEPDRLDITRDASGG------- 337 Query: 428 FPFSLGHRSCIGQQFAQMEVKVVMAKLL-QRLEFRLVPGQRFGLQEQATL-KPLDPVLCT 485 F G C+G Q A++E +V + +L R E L G + ++TL + L + T Sbjct: 338 VFFGHGIHFCLGAQLARLEGRVAIGRLFADRPELALAVGLDELVYRRSTLVRGLSRMPVT 397 Query: 486 LRPR 489 + PR Sbjct: 398 MGPR 401 >2Z36-A nrPDB Length = 413 Score = 216 bits (550), Expect = 2e-56, Method: Composition-based stats. Identities = 79/432 (18%), Positives = 154/432 (35%), Gaps = 72/432 (16%) Query: 69 KKYGPVVRVNV-FHKTSVIVTSPESVKKFLMSTKYNKDSKMYRA---------LQTVFGE 118 ++ P+ +V + + V+ E + L +++ D + LQ + + Sbjct: 32 RERAPINKVRLTSGGQAWWVSGHEEARAVLADGRFSSDKRKDGFPLFTLDAATLQQLRSQ 91 Query: 119 RLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPV 178 G+ + RR + F+ L +L + + ++ + A Q PV Sbjct: 92 PPLMLGM----DGAEHSAARRPVIGEFTVKRLAALRPRIQDIVDHFIDDM--LATDQRPV 145 Query: 179 SMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRK 238 + L+ ++ G+ + Q+ M+ R Sbjct: 146 DLVQALSLPVPSLVICELLGVPYT-----DHDFFQSRTTMMV---------------SRT 185 Query: 239 QLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQIL--KAEEGAQDDEGLLDNF 296 + + R + LR D + R + E D+ ++ + + +EG D GL+ Sbjct: 186 SMEDRRRAFAELRAYIDDLITR------KESEPGDDLFSRQIARQRQEGTLDHAGLVSLA 239 Query: 297 VTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQV 356 AGHET+AN ++ V+ L PE + ++A Sbjct: 240 FLLLTAGHETTANMISLGVVGLLSHPEQLTVVKANPGR------------------TPMA 281 Query: 357 LKESLRLYPPAWGTF-RLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDR 415 ++E LR + A G RL E+ I GV + ++ S F+DP + +R Sbjct: 282 VEELLRYFTIADGVTSRLATEDVEIGGVSIKAGEGVIVSMLSANWDPAVFKDPAVLDVER 341 Query: 416 FGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLE-FRL-VPGQRFGLQEQ 473 + F G C+GQ A+ME+++V L +R+ RL VP + + Sbjct: 342 -------GARHHLAFGFGPHQCLGQNLARMELQIVFDTLFRRIPSLRLAVPMEDVPFKGD 394 Query: 474 ATLKPLDPVLCT 485 + + + + T Sbjct: 395 SVIYGVHELPVT 406 >2ZBZ-A nrPDB Length = 412 Score = 215 bits (547), Expect = 4e-56, Method: Composition-based stats. Identities = 78/436 (17%), Positives = 154/436 (35%), Gaps = 64/436 (14%) Query: 59 VLQDVFLDWAKKYGPVVRVNVF-HKTSVIVTSPESVKKFLMSTKYNKDS--KMYRALQTV 115 L D + GP+ RV ++ + + +VT E+ +K L + + + + A Sbjct: 25 QLPDGYAQLRDTPGPLHRVTLYDGRQAWVVTKHEAARKLLGDPRLSSNRTDDNFPATSPA 84 Query: 116 FGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQ 175 F + +RR+ F+ + + E ++ + Sbjct: 85 FEAVRESPQAFIGLDPPEHGTRRRMTISEFTVKRIKGMRPEVEEVVHGFLDEM---LAAG 141 Query: 176 TPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGIT-ASRNTLAKFLP 234 + ++ G+ + Q + V+ +RN LA +L Sbjct: 142 PTADLVSQFALPVPSMVICRLLGVPYADHEFFQDASKRLVQSTDAQSALTARNDLAGYLD 201 Query: 235 GKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAE--EGAQDDEGL 292 G Q + E A ++ ++ + G D E L Sbjct: 202 GLITQFQT---------------------------EPGAGLVGALVADQLANGEIDREEL 234 Query: 293 LDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQY 352 + + IAGHET+A+ + +V+ L PE A L+A+ V G Sbjct: 235 ISTAMLLLIAGHETTASMTSLSVITLLDHPEQYAALRADRSLVPG--------------- 279 Query: 353 LSQVLKESLRLYPPAWGT-FRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTF 411 ++E LR A R+ + ++G + ++ + R T +EDP Sbjct: 280 ---AVEELLRYLAIADIAGGRVATADIEVEGQLIRAGEGVIVVNSIANRDGTVYEDPDAL 336 Query: 412 NPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLE-FRL-VPGQRFG 469 + R + F G C+GQ A++E++V++ L+ R+ RL VP ++ Sbjct: 337 DIHR-------SARHHLAFGFGVHQCLGQNLARLELEVILNALMDRVPTLRLAVPVEQLV 389 Query: 470 LQEQATLKPLDPVLCT 485 L+ T++ ++ + T Sbjct: 390 LRPGTTIQGVNELPVT 405 >4Z5P-A nrPDB Length = 400 Score = 214 bits (546), Expect = 5e-56, Method: Composition-based stats. Identities = 78/440 (17%), Positives = 149/440 (33%), Gaps = 64/440 (14%) Query: 54 EVGGRVLQDVFLDWAKKYGPVVRVNVF-HKTSVIVTSPESVKKFLMSTKYNKDSKMYRAL 112 EV G + F + ++ P+ RV + +VT + V+ +++ + Sbjct: 16 EVDGLEIHPKFAEL-RETDPLARVRLPYGGEGWMVTRYDDVRAANSDPRFS---RAQIGE 71 Query: 113 QTVFGERLFGQG-LVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAK 171 T L + + + + RR++ AF+ + ++ E L++ +E Sbjct: 72 DTPRTTPLARRSDTILSLDPPEHTRLRRLLSKAFTARRMGAMQSWLEELFAGLLDGVERT 131 Query: 172 ADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAK 231 P + L + G+ Q Sbjct: 132 GH---PADIVRDLAQPFTIAVICRLLGVPYEDRGRFQHWSEV------------------ 170 Query: 232 FLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKA--EEGAQDD 289 + E + +R D V RR A D+L ++ A ++ + Sbjct: 171 IMSTTAYSKEEAVSADASIRAYLADLVSARRAA------PHDDLLGVLVSARDDDDRLTE 224 Query: 290 EGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGR 349 + L+ VT +AGHETSA+ L V L + ++ L+ + + Sbjct: 225 DELITFGVTLLVAGHETSAHQLGNMVYALLTHEDQLSLLREQPE---------------- 268 Query: 350 LQYLSQVLKESLRLYPPAWGT--FRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFED 407 L + ++E LR P G R+ E+ + G V ++ + R F+D Sbjct: 269 --LLPRAVEELLRFVPLGNGVGNARIALEDVELSGGTVRAGEGVVAAAVNANRDPRAFDD 326 Query: 408 PLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLE-FRL-VPG 465 P + R + + F G C+G Q A+ME++V + LL+R RL VP Sbjct: 327 PDRLDITR-------EKNPHLAFGHGAHYCLGAQLARMELRVAIGGLLERFPGLRLAVPA 379 Query: 466 QRFGLQEQATLKPLDPVLCT 485 + + + + Sbjct: 380 DQVEWKTGGLFRGPQRLPIA 399 >3ABA-A nrPDB Length = 403 Score = 214 bits (545), Expect = 6e-56, Method: Composition-based stats. Identities = 72/419 (17%), Positives = 143/419 (34%), Gaps = 59/419 (14%) Query: 73 PVVRVNV-FHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNY 131 PV R + +VT E V+ L + ++ Q + G+G + + Sbjct: 33 PVTRATFTSGHEAWLVTGYEEVRALLRDSSFSVQVPHALHTQDGVVTQKPGRGSLLWQDE 92 Query: 132 ERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDI 191 R+++ F+ + +L ++ ++ +EA+ PV + + Sbjct: 93 PEHTSDRKLLAKEFTVRRMQALRPNIQRIVDEHLDAIEARG---GPVDLVKTFANAVPSM 149 Query: 192 LAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLR 251 + FG+ Q +A+ + + + L Sbjct: 150 VISDLFGVPVERRAEFQD-------------------IAEAMMRVDQDAAATEAAGMRLG 190 Query: 252 QVGRDWVQRRREALKRGEEVPADILTQILKAEE--GAQDDEGLLDNFVTFFIAGHETSAN 309 + VQ RR D+++ ++ E+ G DD L++ T IA H+T+A Sbjct: 191 GLLYQLVQERRA------NPGDDLISALITTEDPDGVVDDMFLMNAAGTLLIAAHDTTAC 244 Query: 310 HLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPA-W 368 + L P+ +A L+ + + ++E LR + Sbjct: 245 MIGLGTALLLDSPDQLALLREDP------------------SLVGNAVEELLRYLTIGQF 286 Query: 369 GTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYF 428 G R+ + + GVR+ ++ + E+P F+ R + Sbjct: 287 GGERVATRDVELGGVRIAKGEQVVAHVLAADFDPAFVEEPERFDITRRPA-------PHL 339 Query: 429 PFSLGHRSCIGQQFAQMEVKVVMAKLLQRLE-FRLV-PGQRFGLQEQATLKPLDPVLCT 485 F G CIGQQ A++E+++V L +RL RL P + + + + T Sbjct: 340 AFGFGAHQCIGQQLARIELQIVFETLFRRLPGLRLAKPVEELRFRHDMVFYGVHELPVT 398 >1ODO-A nrPDB Length = 408 Score = 214 bits (544), Expect = 9e-56, Method: Composition-based stats. Identities = 86/433 (19%), Positives = 153/433 (35%), Gaps = 67/433 (15%) Query: 69 KKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKM-YRALQTVFGERLFGQGL-- 125 ++ GP V+V + V+ P +K+ L S+ +KD++ + A V G + Sbjct: 25 REGGPATWVDVLGVQAWSVSDPVLLKQLLTSSDVSKDARAHWPAFGEVVGTWPLALWVAV 84 Query: 126 --VSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDM 183 + K RR++ AFS + ++ LV+ L G+ PV ++ Sbjct: 85 ENMFTAYGPNHRKLRRLVAPAFSARRVDAMRPAVEAMVTGLVDRLAELPAGE-PVDLRQE 143 Query: 184 LTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREV 243 L Y + G+ G + +++G+ + A E Sbjct: 144 LAYPLPIAVIGHLMGVPQDRRDG--------FRALVDGVFDTTLDQA-----------EA 184 Query: 244 RESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDD------EGLLDNFV 297 + + L +V + +R P D +T +L A + D E L D + Sbjct: 185 QANTARLYEVLDQLIAAKRAT-------PGDDMTSLLIAARDDEGDGDRLSPEELRDTLL 237 Query: 298 TFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVL 357 AG+ET+ N + V L +P+ +A ++ + + D V+ Sbjct: 238 LMISAGYETTVNVIDQAVHTLLTRPDQLALVRK---------GEVTWAD---------VV 279 Query: 358 KESLRLYPPAWGTF-RLLEEETLI-DGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDR 415 +E+LR P R + + DG + P+L S R + ED TF+ R Sbjct: 280 EETLRHEPAVKHLPLRYAVTDIALPDGRTIARGEPILASYAAANRHPDWHEDADTFDATR 339 Query: 416 FGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRL-EFRL-VPGQRFGLQEQ 473 + F G C+G A+MEV + + L R + RL P + Sbjct: 340 TVK-------EHLAFGHGVHFCLGAPLARMEVTLALESLFGRFPDLRLADPAEELPPVPS 392 Query: 474 ATLKPLDPVLCTL 486 + L Sbjct: 393 LISNGHQRLPVLL 405 >3WVS-A nrPDB Length = 401 Score = 213 bits (542), Expect = 2e-55, Method: Composition-based stats. Identities = 72/414 (17%), Positives = 141/414 (34%), Gaps = 59/414 (14%) Query: 76 RVNVF-HKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERW 134 RV + + + + T E + L ++++ + + + Sbjct: 40 RVKLPYGEPAWLATRYEDARLVLGDARFSRALSEEHDPPRARKFNAQAKS-MFNMDAPDH 98 Query: 135 HKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAK 194 + RR+I AF+ + L ++ A +L++ + AK + P + + Sbjct: 99 TRLRRLISKAFTIRRVEELRPKVHDLAHRLIDDMLAKGE---PADLVADYALPIPTTVIC 155 Query: 195 AAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVG 254 G+ ++ + +L T E R L Sbjct: 156 ELLGVPFE----DREKFGRWTDAILSTSTL--------------NPEEGRVKRMELVGYI 197 Query: 255 RDWVQRRREALKRGEEVPADILTQILKAEE--GAQDDEGLLDNFVTFFIAGHETSANHLA 312 + RR + D+++ +++A + ++ LLD+ + IAGHET+A+ + Sbjct: 198 GGIIAARRA------QPADDLISGMIEARDVQDKLTEQELLDHCIGLLIAGHETTASQIP 251 Query: 313 FTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWG--T 370 V L QP+ RL + + + ++E R P G Sbjct: 252 SFVYALLDQPQHWKRLLDDPE------------------LIPSAVEELFRFVPLGSGSAA 293 Query: 371 FRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPF 430 R E+ + G V P+L + R FEDP DR P + F Sbjct: 294 PRYAREDIEVGGTLVRAGEPVLVALGAANRDGLRFEDPEEIKLDR-------PSNHHIGF 346 Query: 431 SLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPVLC 484 G C+G A++E++ + LL+RL V G + + ++ + Sbjct: 347 GHGIHHCLGAPLARLELQEALRALLERLPTLKVAG-DIAWKSEMMVRGPRSMPV 399 >2WIO-A nrPDB Length = 431 Score = 210 bits (535), Expect = 1e-54, Method: Composition-based stats. Identities = 66/388 (17%), Positives = 124/388 (31%), Gaps = 57/388 (14%) Query: 73 PVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYE 132 PV + V V+ L T + + + G G++ E + Sbjct: 62 PVWQDRYG---VWHVFRHADVQTVLRDT----ATFSSDPTRVIEGASPT-PGMIHEIDPP 113 Query: 133 RWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDIL 192 R+V+ AF+ ++ L + L+ AD + D+L + + Sbjct: 114 EHRALRKVVSSAFTPRTISDLEPRIRDVTRSLL------ADAGESFDLVDVLAFPLPVTI 167 Query: 193 AKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQ 252 LLG + + + P + + + L Sbjct: 168 VA--------ELLGLPPMDHEQFGDWSGALVDIQMD----DPTDPALAERIADVLNPLTA 215 Query: 253 VGRDWVQRRREALKRGEEVPADILTQILKAEEGAQ--DDEGLLDNFVTFFIAGHETSANH 310 + RR + D++++++ AE + DDE + +AGH T+ Sbjct: 216 YLKARCAERRA------DPGDDLISRLVLAEVDGRALDDEEAANFSTALLLAGHITTTVL 269 Query: 311 LAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGT 370 L V L P + + +++E LR PP Sbjct: 270 LGNIVRTLDEHPAHWDAAAEDPGR------------------IPAIVEEVLRYRPPFPQM 311 Query: 371 FRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPF 430 R + T + GV +P + + R +DP F+P R GA + F Sbjct: 312 QRTTTKATEVAGVPIPADVMVNTWVLSANRDSDAHDDPDRFDPSRKSGGAAQ-----LSF 366 Query: 431 SLGHRSCIGQQFAQMEVKVVMAKLLQRL 458 G C+G A++E +V + +++ R Sbjct: 367 GHGVHFCLGAPLARLENRVALEEIIARF 394 >1Z8P-A nrPDB Length = 404 Score = 210 bits (534), Expect = 1e-54, Method: Composition-based stats. Identities = 74/446 (16%), Positives = 147/446 (32%), Gaps = 75/446 (16%) Query: 63 VFLDWAKKYG------PVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVF 116 +DW + Y PV V + + +VT + K L + + D K V Sbjct: 12 FHVDWYRTYAELRETAPVTPVRFLGQDAWLVTGYDEAKAALSDLRLSSDPKKKYPGVEVE 71 Query: 117 GERLFGQ---------GLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEI 167 G + + + R+++ F+ + ++ + +L++ Sbjct: 72 FPAYLGFPEDVRNYFATNMGTSDPPTHTRLRKLVSQEFTVRRVEAMRPRVEQITAELLDE 131 Query: 168 LEAKADGQTPVSMQDMLTYT-AMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASR 226 + V + D + + ++ LLG + I Sbjct: 132 VGDSG----VVDIVDRFAHPLPIKVIC---------ELLGVDEKYRGEFGRWSSEILVM- 177 Query: 227 NTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILK---AE 283 ++ + ++ R + D V+RRR E D+L+ +++ + Sbjct: 178 ---------DPERAEQRGQAAREVVNFILDLVERRR------TEPGDDLLSALIRVQDDD 222 Query: 284 EGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLD 343 +G + L + +AG E+S + + L P+ +A ++ + Sbjct: 223 DGRLSADELTSIALVLLLAGFESSVSLIGIGTYLLLTHPDQLALVRRDPSA--------- 273 Query: 344 FEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDT 403 L ++E LR P T R EE I GV +P + +L + R Sbjct: 274 ---------LPNAVEEILRYIAPPETTTRFAAEEVEIGGVAIPQYSTVLVANGAANRDPK 324 Query: 404 YFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRL- 462 F DP F+ R G + F G C+G+ A++E +V + L R Sbjct: 325 QFPDPHRFDVTRDTRG-------HLSFGQGIHFCMGRPLAKLEGEVALRALFGRFPALSL 377 Query: 463 -VPGQRFGLQEQATLKPLDPVLCTLR 487 + + L+ +D + L Sbjct: 378 GIDADDVVWRRSLLLRGIDHLPVRLD 403 >5XNT-A nrPDB Length = 411 Score = 209 bits (531), Expect = 3e-54, Method: Composition-based stats. Identities = 75/416 (18%), Positives = 151/416 (36%), Gaps = 60/416 (14%) Query: 81 HKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGL-----VSECNYERWH 135 + V E VK+ L + Y S + + G + ++E + Sbjct: 40 GTDTWNVFKYEDVKRVL--SDYKHFSSVRKRTTISVGTDSEEGSVPDKIKITEADPPEHR 97 Query: 136 KQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKA 195 K+R ++ AF+ SL + E A++L+E ++ + + + + L I+ Sbjct: 98 KRRSLLAAAFTPRSLQNWEPRIQEIADELIEEMDEETE----IDIVQSLASPLPIIVMSD 153 Query: 196 AFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGR 255 G+ + L K ++ + FLP +++ EV E + + Sbjct: 154 LMGVPSKDRL--------LFKKWVDIL---------FLPFDKEKQEEVNELKQVAAKEYY 196 Query: 256 DWVQRRREALKRGEEVPADILTQILKAEEGAQ--DDEGLLDNFVTFFIAGHETSANHLAF 313 ++ +++ DI++ +LKAE + D+ ++ + AG ET+++ LA Sbjct: 197 QYLYPIV--VQKRLNPADDIISDLLKAEVDGEMFTDDEVVRTTMLILGAGVETTSHLLAN 254 Query: 314 TVMELS-RQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFR 372 + L E+ L +D + Q ++E LR R Sbjct: 255 SFYSLLYDDKEVYQELHENLD------------------LVPQAVEEMLRYRFNLIKLDR 296 Query: 373 LLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSL 432 ++E+ + GV + ++ + FED T N R + F Sbjct: 297 TVKEDNDLLGVELKEGENVVVWMSAANLDEEMFEDAFTLNIHR------PNNKKHLTFGN 350 Query: 433 GHRSCIGQQFAQMEVKVVMAKLLQRL-EFRLVPGQRFG--LQEQATLKPLDPVLCT 485 G C+G A++E K+ + L++ VP + L + AT + L + Sbjct: 351 GPHFCLGAPLARLEAKIALTTFLKKFKHIEAVPSFQLEDNLTDSATGQTLTSLPLK 406 >1EHE-A nrPDB Length = 403 Score = 207 bits (526), Expect = 1e-53, Method: Composition-based stats. Identities = 71/394 (18%), Positives = 137/394 (34%), Gaps = 56/394 (14%) Query: 73 PVVRVNVF-HKTSVIVTSPESVKKFLMSTKYNKDS--KMYRALQTVFGERLFGQGLVSEC 129 PV +V +F + +VT + V S K +K + + L + + + Sbjct: 30 PVSQVKLFDGSLAWLVTKHKDVCFVATSEKLSKVRTRQGFPELSASGKQAAKAKPTFVDM 89 Query: 130 NYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAM 189 + QR +++ F+ ++ +L + L+E ++ K PV + Sbjct: 90 DPPEHMHQRSMVEPTFTPEAVKNLQPYIQRTVDDLLEQMKQKGCANGPVDLVKEFALPVP 149 Query: 190 DILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRF 249 + G+ + L + + RE + + Sbjct: 150 SYIIYTLLGVPFNDLEYLTQQNAIRTN-------------------GSSTAREASAANQE 190 Query: 250 LRQVGRDWVQRRREALKRGEEVPADILTQIL--KAEEGAQDDEGLLDNFVTFFIAGHETS 307 L V++R E DI++++ + + G D + +AG+ T Sbjct: 191 LLDYLAILVEQRL------VEPKDDIISKLCTEQVKPGNIDKSDAVQIAFLLLVAGNATM 244 Query: 308 ANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYP-P 366 N +A V L++ P+ +A+L+A Q ++E R + Sbjct: 245 VNMIALGVATLAQHPDQLAQLKANP------------------SLAPQFVEELCRYHTAS 286 Query: 367 AWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDR-FGPGAPKPRF 425 A R +E+ +I V N ++ S R + FE+P FN +R + P P Sbjct: 287 ALAIKRTAKEDVMIGDKLVRANEGIIASNQSANRDEEVFENPDEFNMNRKWPPQDP---- 342 Query: 426 TYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLE 459 F G CI + A+ E+ V + L Q+ Sbjct: 343 --LGFGFGDHRCIAEHLAKAELTTVFSTLYQKFP 374 >4YT3-A nrPDB Length = 410 Score = 206 bits (525), Expect = 1e-53, Method: Composition-based stats. Identities = 77/418 (18%), Positives = 149/418 (35%), Gaps = 64/418 (15%) Query: 81 HKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGL-----VSECNYERWH 135 + V E VK+ L + Y S + + G + ++E + Sbjct: 40 GTDTWNVFKYEDVKRVL--SDYKHFSSVRKRTTISVGTDSEEGSVPEKIQITESDPPDHR 97 Query: 136 KQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKA 195 K+R ++ AF+ SL + E A++L+ + DG T + + L I+ Sbjct: 98 KRRSLLAAAFTPRSLQNWEPRIQEIADELI----GQMDGGTEIDIVASLASPLPIIVMAD 153 Query: 196 AFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGR 255 G+ + L K ++ + + RE +E + L+QV Sbjct: 154 LMGVPSKDRL--------LFKKWVDTLFLPFD-------------REKQEEVDKLKQVAA 192 Query: 256 DWVQRRREAL--KRGEEVPADILTQILKAEEGAQ--DDEGLLDNFVTFFIAGHETSANHL 311 + + ++ DI++ +LK+E + D+ ++ + AG ET+++ L Sbjct: 193 KEYYQYLYPIVVQKRLNPADDIISDLLKSEVDGEMFTDDEVVRTTMLILGAGVETTSHLL 252 Query: 312 AFTVMELS-RQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGT 370 A + L E+ L +D + Q ++E LR Sbjct: 253 ANSFYSLLYDDKEVYQELHENLD------------------LVPQAVEEMLRFRFNLIKL 294 Query: 371 FRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPF 430 R ++E+ + GV + ++ + FEDP T N R + F Sbjct: 295 DRTVKEDNDLLGVELKEGDSVVVWMSAANMDEEMFEDPFTLNIHR------PNNKKHLTF 348 Query: 431 SLGHRSCIGQQFAQMEVKVVMAKLLQRL-EFRLVPGQRFG--LQEQATLKPLDPVLCT 485 G C+G A++E K+ + L++ VP + L + AT + L + Sbjct: 349 GNGPHFCLGAPLARLEAKIALTAFLKKFKHIEAVPSFQLEENLTDSATGQTLTSLPLK 406 >5Y1I-A nrPDB Length = 403 Score = 206 bits (523), Expect = 2e-53, Method: Composition-based stats. Identities = 64/417 (15%), Positives = 136/417 (32%), Gaps = 58/417 (13%) Query: 76 RVNVFHKTSVIVTSPESVKKFLMSTKYNKDS--KMYRALQTVFGERLFGQGLVSECNYER 133 R+ +VT + L + + D Y + F Q + + Sbjct: 37 RIWDGSTP-WVVTRHADQRALLSDPRVSHDGLRDGYPHISADFKFLSMAQPSFAGQDDPE 95 Query: 134 WHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILA 193 + RR++ L F+ + ++ + ++L++ + G PV + + L + Sbjct: 96 HGRIRRMVTLPFTARRIEAMRPAIQKITDELIDGM---LAGPKPVDLVEALALPVPVRVI 152 Query: 194 KAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQV 253 G+ Q+ N + + + +L+++ Sbjct: 153 CEMLGVPYEDREFLQQN---------------NNAMIYRDTAQGDAQKAAIAQAMYLKEL 197 Query: 254 GRDWVQRRREALKRGEEVPADILTQI-LKAEEGAQDDEGLLDNFVTFFIAGHETSANHLA 312 + R DIL+ + ++ E G + + AGHET+AN +A Sbjct: 198 VGTKLGDR----------GDDILSDLAVQVEAGEITQDDAAGIGMMLLGAGHETTANMIA 247 Query: 313 FTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAW-GTF 371 + L PE +A ++ D + + ++E LR A Sbjct: 248 LGTLALLENPEQLAEVR----------------DSDDPKVIVNTVEELLRYLTIAQDTVR 291 Query: 372 RLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFED-PLTFNPDRFGPGAPKPRFTYFPF 430 R+ E+ I GV + ++F + + P + R + F Sbjct: 292 RIAAEDIEIGGVVIKAGEGIVFPLNAANWDPDLYPEAPDRLDIHR------ANARRHLAF 345 Query: 431 SLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQ--RFGLQEQATLKPLDPVLCT 485 G C+G A++E+++V + LL+R+ + G + + + T Sbjct: 346 GYGVHQCLGATLARVELQIVYSTLLRRIPTLALAGTLDEIPFKHDQIAHGVYELPVT 402 >3ABB-A nrPDB Length = 408 Score = 206 bits (523), Expect = 3e-53, Method: Composition-based stats. Identities = 77/432 (17%), Positives = 149/432 (34%), Gaps = 75/432 (17%) Query: 73 PVVRVNVF-HKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSE--- 128 P+ +V +F + + ++T + L+ + + D V R +G ++ Sbjct: 38 PLTQVTLFDGRPAWLITGHAEGRALLVDPRLSSDWGHPDF--PVVVRRTEDRGGLAFPLI 95 Query: 129 -CNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYT 187 + +QRR++ +F + ++ ++L++ + AK G + Sbjct: 96 GVDDPVHARQRRMLIPSFGVKRMNAIRPRLQSLVDRLLDDMLAKGPGA---DLVSAFALP 152 Query: 188 AMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESI 247 + G+ + G S A F Sbjct: 153 VPSVAICELLGVPYG-----DHDFFEECSRNFVGAATSAEADAAF--------------- 192 Query: 248 RFLRQVGRDWVQRRREALKRGEEVPADILTQIL--KAEEGAQDDEGLLDNFVTFFIAGHE 305 L V R++ + G +L +++ + EEG D + ++ + +AGHE Sbjct: 193 GELYTYLHGLVGRKQAEPEDG------LLDELIARQLEEGDLDHDEVVMIALVLLVAGHE 246 Query: 306 TSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYP 365 T+ N +A + L + PE + L + V G V++E LR Sbjct: 247 TTVNAIALGALTLIQHPEQIDVLLRDPGAVSG------------------VVEELLRFTS 288 Query: 366 PAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRF 425 + R+ +E+ + G + +L S +M R +E+P F+ R Sbjct: 289 VSDHIVRMAKEDIEVGGATIKAGDAVLVSITLMNRDAKAYENPDIFDARR-------NAR 341 Query: 426 TYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPVLCT 485 + F G C+GQ A+ E+++ + L R +PG R + PLD V Sbjct: 342 HHVGFGHGIHQCLGQNLARAELEIALGGLFAR-----IPGLRLAV-------PLDEVPIK 389 Query: 486 LRPRGWQPAPPP 497 P P Sbjct: 390 AGHDAQGPIELP 401 >3R9C-A nrPDB Length = 418 Score = 204 bits (520), Expect = 5e-53, Method: Composition-based stats. Identities = 69/381 (18%), Positives = 127/381 (33%), Gaps = 49/381 (12%) Query: 109 YRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEIL 168 R L R G + + R ++ AF+ + L +QL++ + Sbjct: 80 QRQLAAETQPRPQGPASFLFLDPPDHTRLRGLVSKAFAPRVIKRLEPEITALVDQLLDAV 139 Query: 169 EAKADGQTPVSMQDMLTYTAMD-ILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRN 227 + ++ D L Y ++ + LLG + A+ + Sbjct: 140 D-----GPEFNLIDNLAYPLPVAVICR---------LLGVPIEDEPKFSRASALLAAALD 185 Query: 228 TLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGA- 286 E ++ +LR R + RR D+++ ++ EE Sbjct: 186 PFLALTGETSDLFDEQMKAGMWLRDYLRALIDERR------RTPGEDLMSGLVAVEESGD 239 Query: 287 -QDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFE 345 ++ ++ IAGHET+ N +A + + R P A L A+ Sbjct: 240 QLTEDEIIATCNLLLIAGHETTVNLIANAALAMLRTPGQWAALAADGSR----------- 288 Query: 346 DLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYF 405 S V++E++R PP R ++ I VP +L R T Sbjct: 289 -------ASAVIEETMRYDPPVQLVSRYAGDDLTIGTHTVPKGDTMLLLLAAAHRDPTIV 341 Query: 406 EDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPG 465 P F+PDR + + F G C+G A++E V + L R + G Sbjct: 342 GAPDRFDPDR-------AQIRHLGFGKGAHFCLGAPLARLEATVALPALAARFPEARLSG 394 Query: 466 QRFGLQEQATLKPLDPVLCTL 486 + + TL+ + + + Sbjct: 395 EP-EYKRNLTLRGMSTLSIAV 414 >5FOI-A nrPDB Length = 408 Score = 203 bits (515), Expect = 2e-52, Method: Composition-based stats. Identities = 75/395 (18%), Positives = 136/395 (34%), Gaps = 59/395 (14%) Query: 81 HKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRV 140 + +V+ E V+ L+ + D L G+ G + + + RR+ Sbjct: 55 GSPTWLVSRYEHVRALLVDPRVTVDPTRQPRLSEADGDG-DGFRSMLMLDPPEHTRLRRM 113 Query: 141 IDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGME 200 AFS + ++ + + +++ L A + PV + L + G+ Sbjct: 114 FISAFSVRQVETMRPEIEKIVDGILDRLLAL---EPPVDILTHLALPMSTQVICHLLGVP 170 Query: 201 TSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQR 260 Q+ A + + + L ++L G L + + +G +R Sbjct: 171 YEDREFFQERSELASRPNDDRSMPALIELVEYLDG----LVRTKTAHPDTGLLGTAVTER 226 Query: 261 RREALKRGEEVPADILTQILKAEEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSR 320 +LK E + L++N V AGHETSAN + +V+ L R Sbjct: 227 ------------------LLKGE---ITHQELVNNAVLLLAAGHETSANQVTLSVLTLLR 265 Query: 321 QPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLI 380 PE A L+ + + + + E LR + A G R + ++ Sbjct: 266 HPETAAELREQPE------------------LMPNAVDELLRYHSIADGLRRAATADIVL 307 Query: 381 DGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQ 440 + L+ F TF+ R P + F G C+GQ Sbjct: 308 GDHTIRAGDGLIILLSSANHDGNTFGAEATFDIHR-------PARHHVAFGYGPHQCLGQ 360 Query: 441 QFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQAT 475 A++E++V + KL +R VP R + A Sbjct: 361 NLARLEMEVTLGKLFRR-----VPALRLAQEPDAL 390 >5XJN-A nrPDB Length = 455 Score = 202 bits (513), Expect = 3e-52, Method: Composition-based stats. Identities = 64/445 (14%), Positives = 130/445 (29%), Gaps = 55/445 (12%) Query: 50 WKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMS--------TK 101 + + ++ + + +VT + +K + Sbjct: 54 HGYQPFDMHNPFPAYKELRQEEPVMFDERIG---YWVVTKYDDIKTTFDDWETFSSENAQ 110 Query: 102 YNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKA 161 + +A Q + +S + R + AF+ +L Sbjct: 111 APVRKRGPQATQIMTDGGFTAYSGLSARIPPEHTRIRAIAQKAFTPRRYKALEPDIRAMV 170 Query: 162 EQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEG 221 VE + A+ Q M L Y I G + SM+ ++ + + Sbjct: 171 IDRVEKM--LANDQHVGDMVSDLAYDIPTITILTLIGADISMVDTYKRWSDS--RAAMTW 226 Query: 222 ITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILK 281 S + +E + + G G+ + AD++ + Sbjct: 227 GDLSDEEQIPHAHNLVEYWQECQRMVADAHAHG-------------GDNLTADLVRA--Q 271 Query: 282 AEEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRY 341 E D + + AGHET+ ++ L PE + Sbjct: 272 QEGQEITDHEIASLLYSLLFAGHETTTTLISNCFRVLLDHPEQWQAILENP--------- 322 Query: 342 LDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRM 401 + + + E LR G R ++T I GV + +L R Sbjct: 323 ---------KLIPAAVDEVLRYSGSIVGWRRKALKDTEIGGVAIKEGDGVLLLMGSANRD 373 Query: 402 DTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLE-F 460 + FE+ F+ R + F G C+G A+++ K+ + ++ + + Sbjct: 374 EARFENGEEFDISR------ANAREHLSFGFGIHYCLGNMLAKLQAKICLEEVTRLVPSL 427 Query: 461 RLVPGQRFGLQEQATLKPLDPVLCT 485 LV + G +E + + V T Sbjct: 428 HLVADKAIGFRENLSFRVPTSVPVT 452 >4YZR-A nrPDB Length = 405 Score = 202 bits (513), Expect = 4e-52, Method: Composition-based stats. Identities = 67/452 (14%), Positives = 147/452 (32%), Gaps = 71/452 (15%) Query: 52 KDEVGGRVLQDVF--LDWAKKYGPVVRVNVFHK----TSVIVTSPESVKKFLMSTKYNKD 105 G + F L ++ P+ R + + ++T + FL + +D Sbjct: 6 FHPHGKEFHHNPFSVLGRFREEEPIHRFELKRFGATYPAWLITRYDDCMAFLKDNRITRD 65 Query: 106 SK-----MYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEK 160 K + V + F + + + R ++ AF+ ++ +L + + Sbjct: 66 VKNVMNQEQIKMLNVSEDIDFVSDHMLAKDTPDHTRLRSLVHQAFTPRTIENLRGSIEQI 125 Query: 161 AEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLE 220 AEQL++ +E + + I+ G+ + M++ Sbjct: 126 AEQLLDEMEKENKA----DIMKSFASPLPFIVISELMGIPKE----DRSQFQIWTNAMVD 177 Query: 221 GITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQIL 280 +++R + + RR + D++++++ Sbjct: 178 --------------TSEGNRELTNQALREFKDYIAKLIHDRRI------KPKDDLISKLV 217 Query: 281 KAEEGA--QDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGS 338 AEE ++ L +AG ET+ N L + L + + +L+ + + Sbjct: 218 HAEENGSKLSEKELYSMLFLLVVAGLETTVNLLGSGTLALLQHKKECEKLKQQPE----- 272 Query: 339 KRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTF-RLLEEETLIDGVRVPGNTPLLFSTYV 397 ++ ++E LR P R E+ G + + Sbjct: 273 -------------MIATAVEELLRYTSPVVMMANRWAIEDFTYKGHSIKRGDMIFIGIGS 319 Query: 398 MGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQR 457 R +FE+P N +R + F G C+G A++E + LL+R Sbjct: 320 ANRDPNFFENPEILNINRSPN-------RHISFGFGIHFCLGAPLARLEGHIAFKALLKR 372 Query: 458 L---EFRLVPGQRFGLQEQATLKPLDPVLCTL 486 E + P ++ L+ L+ + +L Sbjct: 373 FPDIELAVAPD-DIQWRKNVFLRGLESLPVSL 403 >5GWE-A nrPDB Length = 405 Score = 202 bits (513), Expect = 4e-52, Method: Composition-based stats. Identities = 64/445 (14%), Positives = 130/445 (29%), Gaps = 55/445 (12%) Query: 50 WKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMS--------TK 101 + + ++ + + +VT + +K + Sbjct: 4 HGYQPFDMHNPFPAYKELRQEEPVMFDERIG---YWVVTKYDDIKTTFDDWETFSSENAQ 60 Query: 102 YNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKA 161 + +A Q + +S + R + AF+ +L Sbjct: 61 APVRKRGPQATQIMTDGGFTAYSGLSARIPPEHTRIRAIAQKAFTPRRYKALEPDIRAMV 120 Query: 162 EQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEG 221 VE + A+ Q M L Y I G + SM+ ++ + + Sbjct: 121 IDRVEKM--LANDQHVGDMVSDLAYDIPTITILTLIGADISMVDTYKRWSDS--RAAMTW 176 Query: 222 ITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILK 281 S + +E + + G G+ + AD++ + Sbjct: 177 GDLSDEEQIPHAHNLVEYWQECQRMVADAHAHG-------------GDNLTADLVRA--Q 221 Query: 282 AEEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRY 341 E D + + AGHET+ ++ L PE + Sbjct: 222 QEGQEITDHEIASLLYSLLFAGHETTTTLISNCFRVLLDHPEQWQAILENP--------- 272 Query: 342 LDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRM 401 + + + E LR G R ++T I GV + +L R Sbjct: 273 ---------KLIPAAVDEVLRYSGSIVGWRRKALKDTEIGGVAIKEGDGVLLLMGSANRD 323 Query: 402 DTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLE-F 460 + FE+ F+ R + F G C+G A+++ K+ + ++ + + Sbjct: 324 EARFENGEEFDISR------ANAREHLSFGFGIHYCLGNMLAKLQAKICLEEVTRLVPSL 377 Query: 461 RLVPGQRFGLQEQATLKPLDPVLCT 485 LV + G +E + + V T Sbjct: 378 HLVADKAIGFRENLSFRVPTSVPVT 402 >4MM0-A nrPDB Length = 399 Score = 201 bits (511), Expect = 6e-52, Method: Composition-based stats. Identities = 76/411 (18%), Positives = 144/411 (35%), Gaps = 62/411 (15%) Query: 81 HKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRV 140 +VT E V+ L +++ + A E F V + + RR+ Sbjct: 44 GDPGFLVTRYEDVRFVLSDPRFSVRQDLPGA--PRLTEMTFE--SVMTTDPPVHTRLRRL 99 Query: 141 IDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGME 200 + F+ + + E AE L++ +E K P + + L + G+ Sbjct: 100 LSRDFTARRIERMRPRLEEIAEGLLDEMEKKGA---PADIVESLAVPFPITVICELLGVP 156 Query: 201 TSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQR 260 + + G + +L + + + + L V Sbjct: 157 MVDVARFR------------GWADTMVSLTGY------SMEDWTAARDALESYLDGLVAA 198 Query: 261 RREALKRGEEVPADILTQILK--AEEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMEL 318 +RE +D+L+ ++ AE+ D + + +AG+E ++N L +V+ L Sbjct: 199 KRE------NPGSDLLSALVATAAEDNELTDHDVRSLSLILLLAGYEPASNQLGSSVLTL 252 Query: 319 SRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWG-TFRLLEEE 377 R P+ +A L+ + L ++E +R P G FR+ E+ Sbjct: 253 LRFPDRLAELRRDPG------------------LLPSAVEELMRYAPAGDGALFRVTLED 294 Query: 378 TLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSC 437 I +P N+ +L ST F+DP DR P + G C Sbjct: 295 VTIGDTHIPANSAVLASTQAANWDPRRFDDPTGLRLDR-------PDNQHTALGHGIHFC 347 Query: 438 IGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQ---EQATLKPLDPVLCT 485 +G A++E++V + LL+R + GL+ + L + T Sbjct: 348 LGAALARVELQVAIGALLRRFPRLALATDESGLRWSSPGSMLSGFAEIPVT 398 >4WPZ-A nrPDB Length = 397 Score = 201 bits (510), Expect = 7e-52, Method: Composition-based stats. Identities = 75/411 (18%), Positives = 149/411 (36%), Gaps = 64/411 (15%) Query: 85 VIVTSPESVKKFLMSTKYNKD--SKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVID 142 +VT V+K L+ ++++ + A+ +L + LV + + R+++ Sbjct: 40 WMVTKHADVRKVLVDSRFSSKVMATAAAAMSETETGKLMNESLV-GMDAPEHTRLRKLVT 98 Query: 143 LAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETS 202 AF+ + +L E QL++ LE PV + + + G+ Sbjct: 99 KAFTARRVETLRPRITELVGQLLDELETLPR---PVDLVKNFSVPLPVRVICELLGVPA- 154 Query: 203 MLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRR 262 G Q +L G +Q+ E + L + + +R Sbjct: 155 ---GDQDTFHAWSNALL---------------GDWQQVVEKEAATVSLVNYFGELIAVKR 196 Query: 263 EALKRGEEVPADILTQILKAEEG--AQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSR 320 E D++++++ +G + ++ + AGHET+AN ++ ++ L Sbjct: 197 E------NPADDLISELIAISDGDSTLTEREIIALSIGILSAGHETTANQISMFLVTLLH 250 Query: 321 QPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYP---PAWGTFRLLEEE 377 PE + +L+ + + + + E LR P RL E Sbjct: 251 NPEELDKLRDNREA------------------IPKAVDELLRFVPLTTTGGIIPRLTTAE 292 Query: 378 TLI-DGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRS 436 + G +P +L + R FED N R + F G Sbjct: 293 VELSGGQVLPAGAVVLPAVATANRDPEVFEDGERLNVTR-------ENNPHLAFGAGIHH 345 Query: 437 CIGQQFAQMEVKVVMAKLLQRLE-FRL-VPGQRFGLQEQATLKPLDPVLCT 485 C+G Q A++E++ + +L R+ RL VP L+ + ++ L+ + T Sbjct: 346 CLGAQLARIELQEALGAILDRMPQVRLAVPESELRLKSASIIRGLESLPIT 396 >4OQS-A nrPDB Length = 433 Score = 201 bits (510), Expect = 7e-52, Method: Composition-based stats. Identities = 70/430 (16%), Positives = 141/430 (32%), Gaps = 69/430 (16%) Query: 70 KYGPVVRVNVF-HKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQ----- 123 K PV + +VTS + + ++ +++ + + +V Sbjct: 32 KLPPVSPMRFPDGHIGWLVTSHAAARTVMIDPRFSNRPEHKHPVFSVIPRPGGATKAPAP 91 Query: 124 GLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDM 183 G + + RR++ F+ + L + E ++ + PV + Sbjct: 92 GWFINMDAPEHTRYRRMLISQFTVRRIKELEPRIVQITEDHLDAMAK---AGPPVDLVQA 148 Query: 184 LTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREV 243 ++ G+ + Q+ + + K EV Sbjct: 149 FALPVPSLVICELLGVSYADHAFFQEQTT-------------------IMASVDKTQDEV 189 Query: 244 RESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDEGLLDNFVTFFIAG 303 ++ L + + V +R + K D+L ++ + DE L + + +AG Sbjct: 190 TTALGKLTRYIAELVATKRLSPK------DDLLGSLIT--DTDLTDEELTNIALLLLVAG 241 Query: 304 HETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRL 363 HET+AN L L + PE +A L + ++E LR Sbjct: 242 HETTANMLGLGTFALLQHPEQIAALDS-----------------------PDAVEELLRY 278 Query: 364 YPPAWG--TFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAP 421 R E+ ++G + + + R F++P DR Sbjct: 279 LSIVHLGTPNRAALEDVELEGQMIRKGDTVAIGLPAVNRDPKVFDEPDILQLDRVD---- 334 Query: 422 KPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLE-FRL-VPGQRFGLQEQATLKPL 479 + F G C+GQQ A++E+++ +L R RL VP + L+E++ + Sbjct: 335 --ARKHAAFGGGIHQCLGQQLARVEMRIGFTRLFARFPSLRLAVPAEEIKLREKSAAYGV 392 Query: 480 DPVLCTLRPR 489 + R Sbjct: 393 WALPVAWDAR 402 >5XW2-A nrPDB Length = 419 Score = 201 bits (510), Expect = 8e-52, Method: Composition-based stats. Identities = 63/405 (15%), Positives = 141/405 (34%), Gaps = 46/405 (11%) Query: 84 SVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDL 143 + V + L S L + + F +G + + + + R+++ Sbjct: 54 AWNVYGYAEAIEVLGDPGT--FSSHMSRLLPMGADEAFTEGDLLQTDPPDHRELRKLVSH 111 Query: 144 AFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSM 203 AF+ + L ++L++ + + + L Y + + ++ Sbjct: 112 AFTPKVVAELEPRITALTQELLDAVADR----DTFDLMTALAYPLPVTVVAELLSIPSAD 167 Query: 204 LLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRRE 263 + +++ V + G + + + +R+ + +LR+ + +R R Sbjct: 168 RHLFEGWMTEIVHSL--GDVSMEDAPEDQERIFEAGMAPMRKMLEYLREHAAECRRRPR- 224 Query: 264 ALKRGEEVPADILTQILKAEEGAQ--DDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQ 321 D++ ++++AE + D +++ IAG+ T+ + TV+ L Sbjct: 225 ---------GDLMGKLIEAEVDGRRLTDNHIVNFAKMLLIAGYLTTTMLIGNTVLCLDSY 275 Query: 322 PEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLID 381 PE AR++A+ + +L+ES+R P T+R + + Sbjct: 276 PEQAARVRADR------------------SLIPGLLEESMRFLSPVAATYRATTRDVEVA 317 Query: 382 GVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQ 441 G R+ + ++ R F +P F+ R + F G C+G Sbjct: 318 GQRLSADQMVMVWFGAANRDARQFAEPELFDMTR-------GPNPHLGFGRGIHFCLGGP 370 Query: 442 FAQMEVKVVMAKLLQRL-EFRLVPGQRFGLQEQATLKPLDPVLCT 485 A+ME +V + LL R E P + + + Sbjct: 371 LARMEGRVALDHLLDRFPELYTDPERPPTFMPGFDTTGVSSLPLR 415 >3TYW-A nrPDB Length = 417 Score = 201 bits (510), Expect = 8e-52, Method: Composition-based stats. Identities = 76/421 (18%), Positives = 155/421 (36%), Gaps = 61/421 (14%) Query: 73 PVVRVNVFHK-TSVIVTSPESVKKFLMSTKYNKD--SKMYRALQTVFGERLFGQGLVSEC 129 PV RV + + + +VT + V++ L + + D + AL E Sbjct: 43 PVARVTLPTRREAWVVTRYDDVRELLSDPRVSADIRRPGFPALGEGEQEAGARFRPFIRT 102 Query: 130 NYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAM 189 + + RR++ AF+ + ++ + +++++ + PV + Sbjct: 103 DAPEHTRYRRMLLPAFTVRRVRAMRPAVQARVDEILDGM---LAAGGPVDLVSAYANAVS 159 Query: 190 DILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRF 249 + G+ L + + I+ SRN+ +V E++ Sbjct: 160 TSVICELLGIPRHDLEFFRD---------VTRISGSRNS----------TAEQVSEALGG 200 Query: 250 LRQVGRDWVQRRREALKRGEEVPADILTQILKAE--EGAQDDEGLLDNFVTFFIAGHETS 307 L + V RRE E D++++++ G E LL AG ET+ Sbjct: 201 LFGLLGGLVAERRE------EPRDDLISKLVTDHLVPGNVTTEQLLSTLGITINAGRETT 254 Query: 308 ANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPA 367 + +A + + L +PE+ A L+ + D + + E LR+ A Sbjct: 255 TSMIALSTLLLLDRPELPAELRKDPD------------------LMPAAVDELLRVLSVA 296 Query: 368 WGTF-RLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFT 426 R+ E+ + G VP + ++ F+DP + R Sbjct: 297 DSIPLRVAAEDIELSGRTVPADDGVIALLAGANHDPEQFDDPERVDFHRTDN-------H 349 Query: 427 YFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQR--FGLQEQATLKPLDPVLC 484 + F G C+GQ A++E++V + LL+R+ + G+R ++ + L+ ++ Sbjct: 350 HVAFGYGVHQCVGQHLARLELEVALETLLRRVPTLRLAGERDQVVVKHDSATFGLEELMV 409 Query: 485 T 485 T Sbjct: 410 T 410 >5YSW-A nrPDB Length = 441 Score = 200 bits (509), Expect = 9e-52, Method: Composition-based stats. Identities = 74/425 (17%), Positives = 148/425 (34%), Gaps = 71/425 (16%) Query: 70 KYGPVVRVNVF-HKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQ----- 123 + GPV R + +V+ E + L +++ D Y + Sbjct: 62 ERGPVARATLAAGDPFWLVSGYEEARAVLSDPRFSSDRFQYHPWFKELSPEFRERLRDDK 121 Query: 124 ---GLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSM 180 G + + R+++ F+ + L +E V+ + G T + Sbjct: 122 ARAGSFINMDPPEHTRYRKLLTGQFTVRRIRELGARIDEIVAGRVDAM---LAGGTTADL 178 Query: 181 QDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQL 240 + A ++ G+ Q+ + A+ M + + Sbjct: 179 MTEFAFPAPSLMICELLGVRYEDRAEFQQ-RASALLQMNAPVAEAV-------------- 223 Query: 241 REVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILK--AEEGAQDDEGLLDNFVT 298 ++ LR + V +R DI++ ++ + A D+ L++ Sbjct: 224 ----KNADALRAFMQALVTDKRA------NPAGDIISGLIHHAGADPALTDDELINIANL 273 Query: 299 FFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLK 358 IAG++T+A+ L + L ++P +A L+ + ++ ++ Sbjct: 274 LLIAGYDTTASMLGLGIFVLLQRPAQLATLRDDPSR------------------IADAVE 315 Query: 359 ESLRLYPPA-WGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFG 417 E LR G FR +E+ G +P + ++ S R ++ DP + R Sbjct: 316 ELLRYLSVVNPGIFRFAKEDLEFAGEHIPAGSTVVVSVVATNRDARHWPDPD-LDLTR-- 372 Query: 418 PGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLK 477 PR + F G C+GQQ A+ME++ A+LL+RL P R + + Sbjct: 373 -----PRGPHLAFGHGVHQCLGQQLARMEMQAGYAELLRRL-----PNVRLAVPPEEVPL 422 Query: 478 PLDPV 482 D + Sbjct: 423 RNDML 427 >4OQR-A nrPDB Length = 457 Score = 200 bits (509), Expect = 9e-52, Method: Composition-based stats. Identities = 71/431 (16%), Positives = 142/431 (32%), Gaps = 69/431 (16%) Query: 70 KYGPVVRVNVF-HKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQ----- 123 K PV + +VTS + + ++ +++ + + +V Sbjct: 71 KLPPVSPMRFPDGHIGWLVTSHAAARTVMIDPRFSNRPEHKHPVFSVIPRPGGATKAPAP 130 Query: 124 GLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDM 183 G + + + RR++ F+ + L E ++ + PV + Sbjct: 131 GWFTNMDAPEHTRYRRMLISQFTVRRIKELEPRIVRITEDHLDAMAK---AGPPVDLVQA 187 Query: 184 LTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREV 243 ++ G+ + Q+ + V + K EV Sbjct: 188 FALPVPSLVICELLGVSYADHAFFQEQTTIMVSV-------------------DKTQDEV 228 Query: 244 RESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDEGLLDNFVTFFIAG 303 ++ L + + V +R + K D+L ++ + DE L + + +AG Sbjct: 229 TTALGKLTRYIAELVATKRLSPK------DDLLGSLIT--DTDLTDEELTNIALILLVAG 280 Query: 304 HETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRL 363 HET+AN L L + PE +A L + ++E LR Sbjct: 281 HETTANMLGLGTFALLQHPEQIANLDS-----------------------PDAVEELLRY 317 Query: 364 YPPAWG--TFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAP 421 R E+ ++G + + + R F++P DR Sbjct: 318 LSIVHLGTPNRAALEDVELEGQMIRKGDTVAIGLPAVNRDPKVFDEPDILQLDRVD---- 373 Query: 422 KPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLE-FRL-VPGQRFGLQEQATLKPL 479 + F G C+GQQ A++E+++ +L R RL VP + L+E++ + Sbjct: 374 --ARKHAAFGGGIHQCLGQQLARVEMRIGFTRLFARFPSLRLAVPAEEIKLREKSAAYGV 431 Query: 480 DPVLCTLRPRG 490 + G Sbjct: 432 WALPVAWDALG 442 >4JBT-A nrPDB Length = 410 Score = 199 bits (505), Expect = 3e-51, Method: Composition-based stats. Identities = 75/422 (17%), Positives = 137/422 (32%), Gaps = 61/422 (14%) Query: 72 GPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQ---TVFGERLFG----QG 124 GP+ R+++ ++ VT ++ L T+ KD + Q L G Sbjct: 30 GPLTRIDLLGVPALAVTGHTLARQLLTDTRLVKDINAWSLWQSGTVTRQWPLIGMIDVDR 89 Query: 125 LVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDML 184 + + + R A +R L +L T +L++ LE V ++ + Sbjct: 90 SMFTVDGPEHRRLRIKTTQALTRRRLDALKPTIERYVAELLDDLERAGADGAVVDLKSVF 149 Query: 185 TYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVR 244 Y + A G+ + Q+ L K +T E Sbjct: 150 AYPLPMRVISALMGVPSE----DQEQLLTWYKAFFSILTPQD---------------ERL 190 Query: 245 ESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGA--QDDEGLLDNFVTFFIA 302 I + + V+R+ E D+ + ++ A +G +E ++ N A Sbjct: 191 RVIDEMHGYFTEMVRRKTA------EPGDDLTSALIYATDGETPLTEEEVIGNLQALVAA 244 Query: 303 GHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLR 362 GHET+ + + V L PE + ++ D IG ++E+LR Sbjct: 245 GHETTVSLILTAVRALLSHPEQLRLVR---DGEIGW---------------ETAIEETLR 286 Query: 363 LYPPAWGT-FRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYF-EDPLTFNPDRFGPGA 420 P R E+ + +P ++ S +GR T D F+ R Sbjct: 287 WDGPVIHLLMRFATEDIDLGDAVIPRGEGVVMSYRAIGRDITVHGADADDFDITR----- 341 Query: 421 PKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLD 480 + F G C G A++E + + L R L P + + Sbjct: 342 -ATAARHISFGHGPHICPGAALARLEAAIALPALFTRFP-HLHPALPLDQIPNLPVLTQN 399 Query: 481 PV 482 + Sbjct: 400 DL 401 >6GK6-A nrPDB Length = 411 Score = 198 bits (503), Expect = 5e-51, Method: Composition-based stats. Identities = 69/414 (16%), Positives = 131/414 (31%), Gaps = 61/414 (14%) Query: 83 TSVIVTSPESVKKFLMSTKYNKDSK-----MYRALQTVFGERLFGQGLVSECNYERWHKQ 137 + + + L + +D + + R + F + + + + Sbjct: 43 PIWVAVRYDDCVELLKDPRLIRDFRKLPDEVRRRYFPLSDRTTFMDQHMLDADPPDHTRL 102 Query: 138 RRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAF 197 R ++ AFS + L E A+ L++ + + + + + + Sbjct: 103 RAIVQRAFSPRMMEGLRPRIQEIADGLIDAVIDRRR----MELIADFAFPLPTAVIAELL 158 Query: 198 GMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDW 257 G+ + K++L R+ + + + R Sbjct: 159 GLPVEDRGR----FRRWTKILLAPAKD------------REFVERAQPVVEEFAAYFRAL 202 Query: 258 VQRRREALKRGEEVPADILTQILKAEEGA--QDDEGLLDNFVTFFIAGHETSANHLAFTV 315 RR+A D+++ +L AEE L +AGHET+ + +A + Sbjct: 203 ADARRKA------PRDDLISGLLLAEEQEHKLSPAELSSMVFLLLVAGHETTVHLIASGM 256 Query: 316 MELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPA-WGTFRLL 374 + L P RL + + ++E+LR PA T R Sbjct: 257 LLLLSHPAERRRLDEDPG------------------LVGSAVEEALRCEGPAELSTIRWS 298 Query: 375 EEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGH 434 E+ + G RVP + R +F DP F+ R + F G Sbjct: 299 LEDIELFGARVPAGEGVAAGLLAANRDPQHFPDPDRFDIGRSPN-------RHIGFGGGI 351 Query: 435 RSCIGQQFAQMEVKVVMAKLLQRLE-FRLVPGQR-FGLQEQATLKPLDPVLCTL 486 C+G A++E + + LL+RL L R E T++ V Sbjct: 352 HFCLGAMLARIEAAIAFSTLLRRLPRIELATSTRDIVWSEWPTIRGPAAVPVVF 405 >6B11-A nrPDB Length = 440 Score = 195 bits (495), Expect = 4e-50, Method: Composition-based stats. Identities = 69/380 (18%), Positives = 121/380 (31%), Gaps = 55/380 (14%) Query: 81 HKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRV 140 +++ + V+ L + + L GE + L++ + R Sbjct: 86 GAPVWLISRQDHVRALLADPRVSIHPAKLPRLSPSDGEAEASRSLLTL-DPPDHGALRGH 144 Query: 141 IDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGME 200 F + L + + L++ L A+ D + + + Sbjct: 145 FIPEFGLRRVRELRPSVEQIVTGLLDDLTARGDEA---DLLADFALPMATQVICRLLDIP 201 Query: 201 TSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQR 260 Q+ QA + E E++ LR + Sbjct: 202 YEDRDYFQERTEQATR--------------------PAAGEEALEALLELRDYLDRLI-- 239 Query: 261 RREALKRGEEVPADILTQIL-KAEEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELS 319 + K G E +L ++ +A G +LDN V AGHET+A+ + +V+ L Sbjct: 240 ---SGKTGRESGDGMLGSMVAQARGGGLSHADVLDNAVLLLAAGHETTASMVTMSVLVLL 296 Query: 320 RQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETL 379 + P L L + E LR A G R + Sbjct: 297 QHPTAWRELTVNPG------------------LLPGAVDELLRYLSIADGLRRSATADIE 338 Query: 380 IDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIG 439 IDG + L+F R + F +P F+ R + F G C+G Sbjct: 339 IDGHTIRAGDGLVFLLAAANRDEAVFSEPEAFDIHR-------SARRHVAFGYGPHQCLG 391 Query: 440 QQFAQMEVKVVMAKLLQRLE 459 Q A+ME++V + +L+RL Sbjct: 392 QNLARMELEVALGAVLERLP 411 >4TRI-A nrPDB Length = 407 Score = 194 bits (493), Expect = 6e-50, Method: Composition-based stats. Identities = 66/419 (15%), Positives = 155/419 (36%), Gaps = 61/419 (14%) Query: 73 PVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYE 132 PV R T+ ++V + + + R Q G + + + Sbjct: 35 PVFRDRNG---LAAATTYQAVLDAERNPELFSSTGGIRPDQP-------GMPYMIDMDDP 84 Query: 133 RWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDIL 192 + +R++++ F+R ++ +++ + L++ + + + + L + Sbjct: 85 QHLLRRKLVNAGFTRKRVMDKVDSIGRLCDTLIDAVCERGECDFVRDIAAPLPMAVI--- 141 Query: 193 AKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQ 252 G +L + L + ++ G+++ + A ++++ ++ + Sbjct: 142 -----GDMLGVLPTERDMLLKWSDDLVCGLSSHVDEAA---------IQKLMDTFAAYTE 187 Query: 253 VGRDWVQRRREALKRGEEVPADILTQILKAEEGAQ--DDEGLLDNFVTFFIAGHETSANH 310 +D + +RR E D+ + ++ +E Q D+ ++ + I G ET+ + Sbjct: 188 FTKDVITKRRA------EPTDDLFSVLVNSEVEGQRMSDDEIVFETLLILIGGDETTRHT 241 Query: 311 LAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGT 370 L+ +L R + L A+VD L ++E LR P Sbjct: 242 LSGGTEQLLRHRDQWDALVADVD------------------LLPGAIEEMLRWTSPVKNM 283 Query: 371 FRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPF 430 R L +T+ G + ++ ++ F DP F DR ++ F Sbjct: 284 CRTLTADTVFHGTELRAGEKIMLMFESANFDESVFGDPDNFRIDR-------NPNSHVAF 336 Query: 431 SLGHRSCIGQQFAQMEVKVVMAKLLQRL-EFRLVPGQRFGLQEQATLKPLDPVLCTLRP 488 G C+G Q A++E++++ ++L+RL + RL L+ + + + P Sbjct: 337 GFGTHFCLGNQLARLELRLMTERVLRRLPDLRLADDAPVPLRPANFVSGPESMPVVFTP 395 >1WIY-A nrPDB Length = 389 Score = 193 bits (490), Expect = 2e-49, Method: Composition-based stats. Identities = 112/447 (25%), Positives = 179/447 (40%), Gaps = 73/447 (16%) Query: 50 WKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMY 109 W + + V L+W + + P + + + ++ PE V+ L++ K + Y Sbjct: 10 WPYLKDLQQDPLAVLLEWGRAH-PRLFLPLPRFPLALIFDPEGVEGALLAEGTTKATFQY 68 Query: 110 RALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILE 169 RAL RL G+GL+++ + W + R+ + F S+ E E+A Sbjct: 69 RALS-----RLTGRGLLTDW-GKSWKEARKALKDPFLPKSVRGYREAMEEEAWAFFGEWR 122 Query: 170 AKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTL 229 + + + ++ +L +A FG S L A+K + + +R+ L Sbjct: 123 GEER-----DLDHEMLALSLRLLGRALFGKPLSPSLA-----EHALKALDRIMAQTRSPL 172 Query: 230 AKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDD 289 A + R+ R + + R EAL I+ Sbjct: 173 ALLDLAAEARFRKDRGA-----------LYREAEAL-------------IVHPPLSHLPR 208 Query: 290 EGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGR 349 E L VT +AGHET A+ L ++ + LS +P+ R+ + + + Sbjct: 209 ERALSEAVTLLVAGHETVASALTWSFLLLSHRPDWQKRVAESEEAALAA----------- 257 Query: 350 LQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPL 409 +E+LRLYPPAW R LE L+ R+P T L+ S YV R+ YF + Sbjct: 258 -------FQEALRLYPPAWILTRRLERPLLLGEDRLPQGTTLVLSPYVTQRL--YFPEGE 308 Query: 410 TFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFG 469 F P+RF P YFPF LG R C+G+ FA +E +V+ +R +P R Sbjct: 309 AFQPERFLAERGTPSGRYFPFGLGQRLCLGRDFALLEGPIVLRAFFRRFRLDPLPFPRVL 368 Query: 470 LQEQATLKPLDPVLCTLRPRGWQPAPP 496 Q TLRP G PA P Sbjct: 369 AQ------------VTLRPEGGLPARP 383 >5Z9I-A nrPDB Length = 398 Score = 193 bits (489), Expect = 2e-49, Method: Composition-based stats. Identities = 77/379 (20%), Positives = 145/379 (38%), Gaps = 45/379 (11%) Query: 83 TSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVID 142 V L + K M + + +G + + + + R ++D Sbjct: 34 QLWNVYGYPESAAILSNPKVFSSDTMRLDPIKLDEAIV--EGDFAHTDPPKHRRLRGLVD 91 Query: 143 LAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETS 202 AF+ S + + + +L++ +E G++ + I+ G+ S Sbjct: 92 HAFTPSLVAKMESRVHGIIHELLDGVE----GKSQFDLVAEFAAPLPLIMISDLLGVPES 147 Query: 203 MLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRR 262 + Q + ML+G + + + + ++L + E + +R W +R Sbjct: 148 ----DRALFRQWMDKMLDGSEKFES--PETVLEQEEELHKELELLWEMRDY---WHERAA 198 Query: 263 EALKRGEEVPADILTQILKAEEGAQ--DDEGLLDNFVTFFIAGHETSANHLAFTVMELSR 320 E+ KR E D+++Q++ AE Q +D + + + GH T+A +A T++ L Sbjct: 199 ESRKRPRE---DLISQLVHAEVDGQKLNDSQISNIANRLLVNGHLTTAMLIANTMLCLDA 255 Query: 321 QPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLI 380 + AR++A+ + +L+ES+R P G R E + Sbjct: 256 FSDQDARVRADR------------------SLVPALLEESMRYMSPICGVGRATNSEVEV 297 Query: 381 DGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQ 440 G +P + LL T R + FE P F+ R + F G C+G+ Sbjct: 298 AGTVIPKDQLLLVWTGAANRDERQFEKPDVFDAGRSPN-------AHLGFGRGIHFCLGR 350 Query: 441 QFAQMEVKVVMAKLLQRLE 459 Q A+ME K + LL RL Sbjct: 351 QLARMESKAAVEILLDRLP 369 >4Z5Q-A nrPDB Length = 423 Score = 189 bits (481), Expect = 2e-48, Method: Composition-based stats. Identities = 68/444 (15%), Positives = 145/444 (32%), Gaps = 59/444 (13%) Query: 45 HLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNK 104 P + G L + + P+ F + + +VT + + L ++++ Sbjct: 33 PAPVAYPFTGSEGLELSQSYAKLFEDGDPIRVQLPFGEPAWLVTRYDDARFVLTDRRFSR 92 Query: 105 DSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQL 164 R + + + + + R ++ AF+ + S E A L Sbjct: 93 HLATQRDEPRMTPRAV--PESILTMDPPDHTRLRTLVSKAFTPRRIESKRAWIGELAAGL 150 Query: 165 VEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITA 224 V ++A G P + + G+ + A+ Sbjct: 151 VADMKA---GGAPAELVGSYALAIPVTVICELLGVPEDDRTRLRGWCDAALST------- 200 Query: 225 SRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEE 284 E +S L++ D V+ RR E D+ + +++A + Sbjct: 201 -----------GELTDEECVQSFMDLQKYFEDLVKERRA------EPRDDLTSALIEARD 243 Query: 285 --GAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYL 342 + L+ ++ I G ET+A+ ++ V L ++ E+ RL A+ + Sbjct: 244 AHDRLAEPELIGLCISILIGGFETTASEISSFVHVLQQRRELWTRLCADPEA-------- 295 Query: 343 DFEDLGRLQYLSQVLKESLRLYPPAWGT--FRLLEEETLIDGVRVPGNTPLLFSTYVMGR 400 + ++E LR P A R E+ + GV V P++ T + R Sbjct: 296 ----------IPAAVEELLRFVPFAANGISPRYALEDMTVGGVLVREGEPVIVDTSAVNR 345 Query: 401 MDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEF 460 F++ DR + F G C+G A++E++ + L++ + Sbjct: 346 DGLVFDNADEVVIDRADN-------RHMVFGHGAHHCLGAHLARVELQEALKALVEGMPG 398 Query: 461 RLVPGQRFGLQEQATLKPLDPVLC 484 + G + ++ + Sbjct: 399 LRLSG-DVEWKADMIIRAPRVMHV 421 >3P3Z-A nrPDB Length = 416 Score = 189 bits (480), Expect = 2e-48, Method: Composition-based stats. Identities = 64/407 (15%), Positives = 135/407 (33%), Gaps = 53/407 (13%) Query: 84 SVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERL--FGQGLVSECNYERWHKQRRVI 141 +++V + + + + + F + + + R + Sbjct: 56 ALLVLRYAEADQLARDKRLISGFRGLVDMVGTPEGPVRDFMVDFLQSLDGADHRRLRGLA 115 Query: 142 DLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMET 201 F+ + ++ EQL++ L Q + ++ G Sbjct: 116 THPFTPRRITAVQPFVRSTVEQLIDKLP-----QGDFDFVQHFPHPLPALVMCQLLGFPL 170 Query: 202 SMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRR 261 G + L L + L +V + + + +++R Sbjct: 171 EDYDTV-------------GRLSIETNLGLALSNDQDILVKVEQGLGRMFDYLVAAIEKR 217 Query: 262 REALKRGEEVPADILTQILKA-EEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSR 320 + E D+ + I++A +G DD L T +AG+ET+ + LA + + ++ Sbjct: 218 K------VEPGDDLTSDIVRAFHDGVLDDYELRTLVATVLVAGYETTNHQLALAMYDFAQ 271 Query: 321 QPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGT-FRLLEEETL 379 P+ +++ + Q ++E LR P T R+ E+ Sbjct: 272 HPDQWMKIKENPE------------------LAPQAVEEVLRWSPTLPVTATRVAAEDFE 313 Query: 380 IDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIG 439 ++GVR+P TP+ +V R F D F+ K F G C+G Sbjct: 314 VNGVRIPTGTPVFMCAHVAHRDPRVFADADRFDIT------VKREAPSIAFGGGPHFCLG 367 Query: 440 QQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPVLCTL 486 A++E+ +A L RL+ + G+ + + + D + Sbjct: 368 TALARLELTEAVAALATRLDPPQIAGE-ITWRHELGVAGPDALPLRF 413 >2WM5-A nrPDB Length = 435 Score = 188 bits (478), Expect = 4e-48, Method: Composition-based stats. Identities = 63/404 (15%), Positives = 131/404 (32%), Gaps = 50/404 (12%) Query: 85 VIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLA 144 +T + V S + E G + + R + R ++ A Sbjct: 77 WALTKYDDVFYASRHPDI-FSSYPNITINDQTPELAEYFGSMIVLDDPRHQRLRSIVSRA 135 Query: 145 FSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSML 204 F+ + + ++A +LV + A + + ++ + I+ + Sbjct: 136 FTPKVVARIEAAVRDRAHRLVSSMIANNPDRQADLVSELAGPLPLQIIC---------DM 186 Query: 205 LGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREA 264 +G K Q + T P E + + + RR Sbjct: 187 MGIPKADHQRI----FHWTNVILGFGD--PDLATDFDEFMQVSADIGAYATALAEDRR-- 238 Query: 265 LKRGEEVPADILTQILKAEEGAQ--DDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQP 322 D+ + +++AE + + F+ +AG+ET+ N + V+ LSR P Sbjct: 239 ----VNHHDDLTSSLVEAEVDGERLSSREIASFFILLVVAGNETTRNAITHGVLALSRYP 294 Query: 323 EIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDG 382 E R ++ D ++E +R P R L ++ + G Sbjct: 295 EQRDRWWSDFDG-----------------LAPTAVEEIVRWASPVVYMRRTLTQDIELRG 337 Query: 383 VRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPF-SLGHRSCIGQQ 441 ++ + R ++ F DP TF+ R + F G C+G Sbjct: 338 TKMAAGDKVSLWYCSANRDESKFADPWTFDLAR-------NPNPHLGFGGGGAHFCLGAN 390 Query: 442 FAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPVLCT 485 A+ E++V +L +++ + + L Q + + + T Sbjct: 391 LARREIRVAFDELRRQMPDVVATEEPARLLSQF-IHGIKTLPVT 433 >1CPT-A nrPDB Length = 428 Score = 187 bits (474), Expect = 1e-47, Method: Composition-based stats. Identities = 63/416 (15%), Positives = 136/416 (32%), Gaps = 50/416 (12%) Query: 83 TSVIVTSPESVKKFLMSTKYNKDSKMYR---------ALQTVFGERLFGQGLVSECNYER 133 I T V + +++ ++++ G ++ + Sbjct: 50 PMWIATKHADVMQIGKQPGLFSNAEGSEILYDQNNEAFMRSISGGCPHVIDSLTSMDPPT 109 Query: 134 WHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILA 193 R + F +S+ L E A+ V+ L M D Y + ++ Sbjct: 110 HTAYRGLTLNWFQPASIRKLEENIRRIAQASVQRLLDFDGECD--FMTDCALYYPLHVVM 167 Query: 194 KAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQV 253 A LG + + + + + + R+ E Sbjct: 168 TA---------LGVPEDDEPLMLKLTQDFFGVHEPDEQAVAAPRQSADEAARRFHETIAT 218 Query: 254 GRDWVQRRREALKRGEEVPADILTQILKAEEGA--QDDEGLLDNFVTFFIAGHETSANHL 311 D+ + R D+++ + ++ DD+ + +V AGH+T+++ Sbjct: 219 FYDYFNGF--TVDRRSCPKDDVMSLLANSKLDGNYIDDKYINAYYVAIATAGHDTTSSSS 276 Query: 312 AFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTF 371 ++ LSR PE +A +++ + +++ E++R P Sbjct: 277 GGAIIGLSRNPEQLALAKSDPA------------------LIPRLVDEAVRWTAPVKSFM 318 Query: 372 RLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFS 431 R +T + G + ++ S R + F +P F+ RF + F Sbjct: 319 RTALADTEVRGQNIKRGDRIMLSYPSANRDEEVFSNPDEFDITRFPN-------RHLGFG 371 Query: 432 LGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPVLCTLR 487 G C+GQ A++E+K+ +LL +L+ + G + P + V Sbjct: 372 WGAHMCLGQHLAKLEMKIFFEELLPKLKSVELSGPPRLVATNFVGGPKN-VPIRFT 426 >3MGX-A nrPDB Length = 415 Score = 186 bits (472), Expect = 2e-47, Method: Composition-based stats. Identities = 69/406 (16%), Positives = 138/406 (33%), Gaps = 56/406 (13%) Query: 85 VIVTSPESVKKFL-MSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDL 143 V S + L S + M + G+ ++ +E+ K R+++ Sbjct: 65 WSVFSHRACAAVLAPSAPLTSEYGMMIGFDRDHPDNSGGR-MMVVSEHEQHRKLRKLVGP 123 Query: 144 AFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSM 203 SR++ L E + ++L DG+ + + ++ + G+ Sbjct: 124 LLSRAAARKLAERVRIEVG---DVLGRVLDGEVCDAATAIGPRIPAAVVCEIL-GVPAED 179 Query: 204 LLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRRE 263 + A E R++ + + + RR+ Sbjct: 180 EDMLIDLTNHAFGGEDELFDGMTP----------------RQAHTEILVYFDELITARRK 223 Query: 264 ALKRGEEVPADILTQILKAEEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPE 323 E D+++ ++ ++ DD +L N I G+ET+ + + V L+ P Sbjct: 224 ------EPGDDLVSTLVTDDDLTIDD--VLLNCDNVLIGGNETTRHAITGAVHALATVPG 275 Query: 324 IVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGV 383 ++ L+ +V V++E LR PA R+ + I+G Sbjct: 276 LLTALRDGSADV------------------DTVVEEVLRWTSPAMHVLRVTTADVTINGR 317 Query: 384 RVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFA 443 +P TP++ R F+DP TF P R + F G C+G A Sbjct: 318 DLPSGTPVVAWLPAANRDPAEFDDPDTFLPGR-------KPNRHITFGHGMHHCLGSALA 370 Query: 444 QMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPVLCTLRPR 489 ++E+ VV+ L +R+ R+ + ++ + R Sbjct: 371 RIELSVVLRVLAERVS-RVDLEREPAWLRAIVVQGYRELPVRFTGR 415 >6GII-A nrPDB Length = 479 Score = 185 bits (469), Expect = 4e-47, Method: Composition-based stats. Identities = 73/442 (16%), Positives = 141/442 (31%), Gaps = 58/442 (13%) Query: 64 FLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERL--- 120 F+ WA++ P+ +VT +++K+ S + ++ E Sbjct: 83 FVRWAREQVPIF--YAPKLNYWVVTRYDTIKQIFRDPVTFSPSNVLQSFAQPSAEVRQVL 140 Query: 121 --FGQGL---VSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQ 175 +G + + ++RRV+ F+ L E + V Sbjct: 141 ERYGYAFNRTLVNEDEPMHLERRRVLMEPFASEHLAEHEPMVRELVRRAVNRFIDTGRA- 199 Query: 176 TPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPG 235 + D + + +A G++ ++ I + N + P Sbjct: 200 ---DLVDQMIWEVPFTVALHFLGVDDDDREKMRRF----------AIAHTVNAFGR--PS 244 Query: 236 KRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDEGLLDN 295 +QL V E++ Q + +++ R + I Q L D L Sbjct: 245 PEEQL-AVAETVGQFWQFCGEVLEKMRRTADGPGWMRYSIRQQKLY--PDVVTDSYLHSM 301 Query: 296 FVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQ 355 +A HET+ + L + + A+ + Sbjct: 302 MQAIIVAAHETTVFATTNALKTLLEHETVWREICADP------------------SLIPA 343 Query: 356 VLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDR 415 +E LR P G R E ++GVR+P +L +F+DP F+ R Sbjct: 344 AAEECLRYNGPVAGWRRRTTREVEVEGVRLPVGANILMVVASANHDSAHFDDPEFFDIGR 403 Query: 416 FGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQAT 475 + F G C+G+ +ME+++++ +L +RL + QRF + Sbjct: 404 ------SNASEHLNFGYGAHQCLGRNLGRMEMQIMIEELSRRLPHMRLAEQRFDYLHNVS 457 Query: 476 LKPLDPVLCTLRPRGWQPAPPP 497 + + W PA P Sbjct: 458 FRAPRHLWVE-----WDPAQNP 474 >5EX6-C nrPDB Length = 434 Score = 184 bits (467), Expect = 7e-47, Method: Composition-based stats. Identities = 61/414 (14%), Positives = 128/414 (30%), Gaps = 64/414 (15%) Query: 72 GPVVRVNVFH----KTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQ---- 123 G + RV + + + + T + V++ L + + + G+ +F Sbjct: 62 GELTRVRLGSGADAEHTWLATGHDVVRQVLGDHTRFSTRRRFDRNDEIGGKGVFRPRELV 121 Query: 124 GLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDM 183 G + + + + RR++ F+ + + + E L+ +P + ++ Sbjct: 122 GNLMDYDPPEHTRLRRLLAPGFTHRKIRRMAPYIEQIV---TERLDEMEREGSPADLIEL 178 Query: 184 LTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREV 243 + G+ + Q L+ + R Sbjct: 179 FADEVPGPVLCELLGVPRD----DRAMFLQLCHRHLDASLSG---------------RRR 219 Query: 244 RESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQ-DDEGLLDNFVTFFIA 302 + + V R R + P D L ++ AE G DE L V +A Sbjct: 220 AAAGEAFSRYLVTMVARER-------KDPGDGLIGMVVAEHGDTVTDEELRGVCVQMMLA 272 Query: 303 GHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLR 362 G + + + V+ L R PE +A L+ +V + + E +R Sbjct: 273 GDDNISGMIGLGVLALLRNPEQIAALRGDV------------------PAAERAVDELIR 314 Query: 363 LYP-PAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAP 421 P T R E++ + + +L S R D + R Sbjct: 315 YLTVPYAPTPRTAIEDSTVGDQVIKAGETVLCSLPTANRDPALLPDADRLDVTR------ 368 Query: 422 KPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQAT 475 + F G C+G A++E+++ L +R + + + + Sbjct: 369 -EAVPHVAFGHGVHHCLGAALARLELRIAYTALWRRFPDLRLADPDGATEFRLS 421 >5LIE-A nrPDB Length = 414 Score = 183 bits (465), Expect = 1e-46, Method: Composition-based stats. Identities = 62/408 (15%), Positives = 134/408 (32%), Gaps = 60/408 (14%) Query: 63 VFLDWAKKYGPVVRVNVF-----HKTSVIVTSPESVKKFLMST--KYNKDSKMYRALQTV 115 ++ PV + V + + L + R TV Sbjct: 25 HLFAIHRREAPVYWHRPTEHTPDGEGFWSVATYAETLEVLRDPVTYSSVTGGQRRFGGTV 84 Query: 116 FGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQ 175 + +++ + R + RR++ + + + + +A L++ +E G Sbjct: 85 LQDLPVAGQVLNMMDDPRHTRIRRLVSSGLTPRMIRRVEDDLRRRARGLLDGVEP---GA 141 Query: 176 TPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPG 235 + ++ M ++ +LLG + + +E R + +P Sbjct: 142 PFDFVVEIAAELPMQMIC---------ILLGVPETDRHWLFEAVEPGFDFRGSRRATMPR 192 Query: 236 KRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKA-----EEGAQDDE 290 V ++ L + + +R E D+L+ + A + A D Sbjct: 193 L-----NVEDAGSRLYTYALELIAGKRA------EPADDMLSVVANATIDDPDAPALSDA 241 Query: 291 GLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRL 350 L F F AG ET+ N +A ++ L+ P+ + L+++ Sbjct: 242 ELYLFFHLLFSAGAETTRNSIAGGLLALAENPDQLQTLRSD------------------F 283 Query: 351 QYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLT 410 + L ++E +R P+ R + G + ++ R + F+ Sbjct: 284 ELLPTAIEEIVRWTSPSPSKRRTASRAVSLGGQPIEAGQKVVVWEGSANRDPSVFDRADE 343 Query: 411 FNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRL 458 F+ R + F G C+G A++E++V+ +LL R Sbjct: 344 FDITR-------KPNPHLGFGQGVHYCLGANLARLELRVLFEELLSRF 384 >6CVC-A nrPDB Length = 433 Score = 182 bits (462), Expect = 2e-46, Method: Composition-based stats. Identities = 62/397 (15%), Positives = 131/397 (32%), Gaps = 47/397 (11%) Query: 81 HKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRV 140 K +T + + + S + E G + + R + R + Sbjct: 70 GKGHWALTKHDDIHFASRHPEIFHSSPNIV-IHDQTPELAEYFGSMIVLDDPRHQRLRSI 128 Query: 141 IDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGME 200 + AF+ + + + E+A +LV + + ++ + I+ Sbjct: 129 VSRAFTPKVVARIEASVRERAHRLVAAMIENHPDGQADLVSELAGPLPLQIIC------- 181 Query: 201 TSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQR 260 M+ ++ Q T P E + + Sbjct: 182 -DMMGIPEEDHEQIFH-----WTNVILGFGD--PDLTTDFDEFLQVSMAIGGYATALADD 233 Query: 261 RREALKRGEEVPADILTQILKAEEGAQ--DDEGLLDNFVTFFIAGHETSANHLAFTVMEL 318 RR D+ T +++AE + + F+ +AG+ET+ N ++ ++ L Sbjct: 234 RR------VNHHGDLTTSLVEAEVDGERLSSSEIAMFFILLVVAGNETTRNAISHGMLAL 287 Query: 319 SRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEET 378 SR P+ A+ ++ D + ++E +R P R L ++ Sbjct: 288 SRYPDERAKWWSDFDG-----------------LAATAVEEIVRWASPVVYMRRTLSQDV 330 Query: 379 LIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCI 438 + G ++ + R + F DP TF+ R P P+ + G C+ Sbjct: 331 DLRGTKMAAGDKVTLWYCSANRDEEKFADPWTFDVTR----NPNPQVGF--GGGGAHFCL 384 Query: 439 GQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQAT 475 G A+ E++VV +L +++ + + L Q Sbjct: 385 GANLARREIRVVFDELRRQMPDVVATEEPARLLSQFI 421 >3NC3-A nrPDB Length = 441 Score = 181 bits (460), Expect = 4e-46, Method: Composition-based stats. Identities = 67/383 (17%), Positives = 138/383 (36%), Gaps = 52/383 (13%) Query: 83 TSVIVTSPESVKKFLMSTK-YNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVI 141 S ++ V+ L + S + RA + G ++++ + + +RR++ Sbjct: 75 DSYFISRYHDVRYILQHPDIFTTKSLVERAEPVMRGP------VLAQMHGKEHSAKRRIV 128 Query: 142 DLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMET 201 +F +L L + AE L+ + + + T + Sbjct: 129 VRSFIGDALDHLSPLIKQNAENLLAPYLERGKS----DLVNDFGKTFAVCVTM------- 177 Query: 202 SMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRR 261 +LG K + + G+ A F+ + S+ Q+ + + Sbjct: 178 -DMLGLDKRDHEKISEWHSGV-------ADFITSISQSPEARAHSLWCSEQLSQYLMPVI 229 Query: 262 REALKRGEEVPADILTQILKAE--EGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELS 319 +E R +D+++ + +E A D+ +L + +A E + LA + L Sbjct: 230 KE---RRVNPGSDLISILCTSEYEGMALSDKDILALILNVLLAATEPADKTLALMIYHLL 286 Query: 320 RQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETL 379 PE + + A+ + + + E+LR PP R L ++T+ Sbjct: 287 NNPEQMNDVLADR------------------SLVPRAIAETLRYKPPVQLIPRQLSQDTV 328 Query: 380 IDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPG---APKPRFTYFPFSLGHRS 436 + G+ + +T + R FE P FN R G A + F G + Sbjct: 329 VGGMEIKKDTIVFCMIGAANRDPEAFEQPDVFNIHREDLGIKSAFSGAARHLAFGSGIHN 388 Query: 437 CIGQQFAQMEVKVVMAKLLQRLE 459 C+G FA+ E+++V +L ++ Sbjct: 389 CVGTAFAKNEIEIVANIVLDKMR 411 >2XKR-A nrPDB Length = 398 Score = 181 bits (460), Expect = 5e-46, Method: Composition-based stats. Identities = 62/428 (14%), Positives = 140/428 (32%), Gaps = 67/428 (15%) Query: 73 PVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYE 132 PV R ++ ++V + ++ R Q ++ + + Sbjct: 32 PVFRDRNG---LAAASTYQAVIDAERQPELFSNAGGIRPDQPALP-------MMIDMDDP 81 Query: 133 RWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDIL 192 +R++++ F+R + + + L++ + + + L + Sbjct: 82 AHLLRRKLVNAGFTRKRVKDKEASIAALCDTLIDAVCERGE----CDFVRDLAAPLPMAV 137 Query: 193 AKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQ 252 G+ + V + ++ + + ++ Sbjct: 138 IGDMLGVRPEQRDMFLRWSDDLVTFLSSHVSQ-------------EDFQITMDAFAAYND 184 Query: 253 VGRDWVQRRREALKRGEEVPADILTQILKAEEGA--QDDEGLLDNFVTFFIAGHETSANH 310 R + RR + D+++ ++ +E D+ L+ + I G ET+ + Sbjct: 185 FTRATIAARRA------DPTDDLVSVLVSSEVDGERLSDDELVMETLLILIGGDETTRHT 238 Query: 311 LAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGT 370 L+ +L R + LQ + L ++E LR P Sbjct: 239 LSGGTEQLLRNRDQWDLLQRDP------------------SLLPGAIEEMLRWTAPVKNM 280 Query: 371 FRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPF 430 R+L +T G + ++ + F +P F+ R ++ F Sbjct: 281 CRVLTADTEFHGTALCAGEKMMLLFESANFDEAVFCEPEKFDVQR-------NPNSHLAF 333 Query: 431 SLGHRSCIGQQFAQMEVKVVMAKLLQRL-EFRLVPGQRFGLQEQATLKPLDPVLCTLR-P 488 G C+G Q A++E+ ++ ++L+RL + RLV L+P + V P Sbjct: 334 GFGTHFCLGNQLARLELSLMTERVLRRLPDLRLVADDSV-----LPLRPANFVSGLESMP 388 Query: 489 RGWQPAPP 496 + P+PP Sbjct: 389 VVFTPSPP 396 >6A7J-A nrPDB Length = 411 Score = 181 bits (460), Expect = 5e-46, Method: Composition-based stats. Identities = 72/437 (16%), Positives = 145/437 (33%), Gaps = 68/437 (15%) Query: 72 GPVVRVNV-FHKTSVIVTSPESVKKFLMSTKYNKDSKMYRAL--------QTVFGERLFG 122 GP+ V + VT + + L ++ KD ++ A + G G Sbjct: 26 GPLAEVELPGGVHVYAVTHHKEARALLTDSRVVKDINVWNAWQRGEIPADWPLIGLVNPG 85 Query: 123 QGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQD 182 + +++ + + R ++ A + + L +E L A G+ PV ++ Sbjct: 86 RSMLT-VDGPDHRRLRTLVAQALTVKRVEKLRAGIEALTNASLERLAALPAGE-PVDLKA 143 Query: 183 MLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLRE 242 Y + G++ + ++ + + E Sbjct: 144 EFAYPLPMNVISELMGVDAADHPRLKELFEKFFST-------------------QTPPEE 184 Query: 243 VRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGA--QDDEGLLDNFVTFF 300 V + + L + V+ ++ D+ + ++ A E DE +L+ Sbjct: 185 VPQMMADLGTLFTKIVEEKKA------NPGDDLTSALIAASEDGDHLTDEEILNTLQLII 238 Query: 301 IAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKES 360 AGHET+ + + V L+ PE ++ + G + + V++E+ Sbjct: 239 AAGHETTISLIVNVVEALAIHPEQRKKVLS-----------------GEIPW-EGVIEET 280 Query: 361 LRL-YPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYF-EDPLTFNPDRFGP 418 LR P + R E+ + +P L+ S +GR + + F+ R Sbjct: 281 LRWNTPTSHVLIRFATEDIEVGDKVLPKGEGLVVSFGALGRDEEQYGPTAGDFDATR--- 337 Query: 419 GAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRL-EFRL-VPGQRFGLQEQATL 476 + F G C G +++E + + L +R E L VP + T Sbjct: 338 ----TPNRHIAFGHGPHVCPGAALSRLEAGIALPALYERFPELDLAVPAAELRNKPIVTQ 393 Query: 477 KPLDPVLCTLR-PRGWQ 492 L + L P G Sbjct: 394 NDLHDLPVKLGCPFGHD 410 >1GWI-A nrPDB Length = 411 Score = 181 bits (459), Expect = 6e-46, Method: Composition-based stats. Identities = 73/428 (17%), Positives = 137/428 (32%), Gaps = 64/428 (14%) Query: 72 GPVVRVNV-FHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQT---VFGERLFGQG--- 124 GP+ V + VT K L + KD ++ A + L G Sbjct: 30 GPLAAVELPGGVPVWAVTHHAEAKALLTDPRLVKDINVWGAWRRGEIPADWPLIGLANPG 89 Query: 125 -LVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDM 183 + + + R ++ A + + + E ++L++ L A V ++ Sbjct: 90 RSMLTVDGAEHRRLRTLVAQALTVRRVEHMRGRITELTDRLLDELPA---DGGVVDLKAA 146 Query: 184 LTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREV 243 Y + G+E + L + + + EV Sbjct: 147 FAYPLPMYVVADLMGIEEARLPRLKVLFEKFFST-------------------QTPPEEV 187 Query: 244 RESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEE--GAQDDEGLLDNFVTFFI 301 ++ L + D V +R A D+ + +++A E D ++ Sbjct: 188 VATLTELASIMTDTVAAKRAA------PGDDLTSALIQASENGDHLTDAEIVSTLQLMVA 241 Query: 302 AGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESL 361 AGHET+ + + V+ LS PE A + + G + S V++E+L Sbjct: 242 AGHETTISLIVNAVVNLSTHPEQRALV------LSGEAEW------------SAVVEETL 283 Query: 362 RL-YPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYF-EDPLTFNPDRFGPG 419 R P + R E+ + +P L+ S +GR + F+ R Sbjct: 284 RFSTPTSHVLIRFAAEDVPVGDRVIPAGDALIVSYGALGRDERAHGPTADRFDLTRTSGN 343 Query: 420 APKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPL 479 + F G C G ++ME V + L R + L+ + + Sbjct: 344 ------RHISFGHGPHVCPGAALSRMEAGVALPALYARFPHLDLAVPAAELRNKPVVTQN 397 Query: 480 DPVLCTLR 487 D +R Sbjct: 398 DLFELPVR 405 >6A7I-A nrPDB Length = 411 Score = 179 bits (455), Expect = 2e-45, Method: Composition-based stats. Identities = 73/436 (16%), Positives = 139/436 (31%), Gaps = 66/436 (15%) Query: 72 GPVVRVNV-FHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQT---VFGERLFGQG--- 124 GP+ V + VT + L ++ KD ++ A + L G Sbjct: 26 GPLAEVELPGGVHVYAVTRHAEARALLTDSRVVKDIDVWNAWRRGEIPMDWPLIGLANPG 85 Query: 125 -LVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDM 183 + + + R ++ A + + L +E L A G+ PV ++ Sbjct: 86 RSMLTVDGADHRRLRTLVAQALTVKRVERLRAGIEALTNASLEKLAALPAGE-PVDLKAE 144 Query: 184 LTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREV 243 Y + G++ + ++ + + EV Sbjct: 145 FAYPLPMNVISELMGVDAADHPRLKELFEKFFST-------------------QTPPEEV 185 Query: 244 RESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEE--GAQDDEGLLDNFVTFFI 301 + + L + V +R D+ + ++ A E DE +++ Sbjct: 186 PQMMADLGALFTKIVDAKR------TNPGDDLTSALIAASENGDHLTDEEIVNTLQLIIA 239 Query: 302 AGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESL 361 AGHET+ + + V L PE ++ ++ IG V++E+L Sbjct: 240 AGHETTISLIVNVVEALQTHPEQRKKV---LNGEIGW---------------DGVIEETL 281 Query: 362 RL-YPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYF-EDPLTFNPDRFGPG 419 R P + R E+ + +P L+ S +GR + + F+ R Sbjct: 282 RWNTPTSHVLIRFATEDIEVGDKILPKGEGLIISFGALGRDEEQYGPTAGEFDATR---- 337 Query: 420 APKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRL-EFRL-VPGQRFGLQEQATLK 477 + F G C G +++E + + L +R E L VP + T Sbjct: 338 ---TPNRHIAFGHGPHVCPGAALSRLEAGIALPALYERFPELDLAVPASDLRNKPIVTQN 394 Query: 478 PLDPVLCTLR-PRGWQ 492 L + L P G Sbjct: 395 DLHELPVKLGCPFGGD 410 >4XE3-A nrPDB Length = 407 Score = 178 bits (452), Expect = 4e-45, Method: Composition-based stats. Identities = 66/421 (15%), Positives = 141/421 (33%), Gaps = 61/421 (14%) Query: 73 PVVRVNV--FHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECN 130 PV RV + T+ +VT + L ++++ + A +F G++++ + Sbjct: 39 PVSRVRLPYGEGTAWLVTRMSDARIVLGDSRFSTAAATDPATPRMFPTPPEPDGVLAQ-D 97 Query: 131 YERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMD 190 + RR++ AF+ + + + L++ + +P + + L Sbjct: 98 PPDHTRLRRLVGKAFTARRVEEMRPRVRSLVDSLLDDM---VAHGSPADLVEFLAVPFPV 154 Query: 191 ILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFL 250 + G+ + + + L R E++ + Sbjct: 155 AVICELLGVPLEDR--------DLFRTFSDAM----------LSSTRLTAAEIQRVQQDF 196 Query: 251 RQVGRDWVQRRREALKRGEEVPADILTQILKA--EEGAQDDEGLLDNFVTFFIAGHETSA 308 V +RR+A D+L + A + +++ V+ IAGHETS Sbjct: 197 MVYMDGLVAQRRDA------PTEDLLGALALATDNDDHLTKGEIVNMGVSLLIAGHETSV 250 Query: 309 NHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYP--P 366 N + V L +R + + ++E LR P Sbjct: 251 NQITNLVHLLLT------------------ERKRYESLVADPALVPAAVEEMLRYTPLVS 292 Query: 367 AWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFT 426 A R+ E+ + V V P + R + F+ + R R Sbjct: 293 AGSFVRVATEDVELSTVTVRAGEPCVVHFASANRDEEVFDHADELDFHR-------ERNP 345 Query: 427 YFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLV--PGQRFGLQEQATLKPLDPVLC 484 + F G CIG Q ++E++ ++ L++R + P ++ ++ L+ + Sbjct: 346 HIAFGHGAHHCIGAQLGRLELQEALSALVRRFPTLDLAEPVAGLKWKQGMLIRGLERQIV 405 Query: 485 T 485 + Sbjct: 406 S 406 >5L1U-A nrPDB Length = 401 Score = 178 bits (452), Expect = 4e-45, Method: Composition-based stats. Identities = 79/446 (17%), Positives = 151/446 (33%), Gaps = 65/446 (14%) Query: 51 KKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYR 110 D + L K+ GP+ RV + + +VT + V+ L + + + Sbjct: 11 PFDNPDIMGIAPQMLALQKE-GPIARVGTAGEDAWLVTRYDEVRTLLADRRLRLSNPNPQ 69 Query: 111 ALQTVFGERLFGQGLVSECNYE----RWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVE 166 R F L + ++E R + R ++ FS L + ++L++ Sbjct: 70 P-SAKSAARAFMVALAAGDDHETEPARHAQMRSLLIPRFSTRRLRLMKTRIEHHVDELLD 128 Query: 167 ILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASR 226 L A A PV + +L++ ++ G+ L ++ Q + + Sbjct: 129 QLAASA---PPVDLHRVLSFRLPTMVVCDLLGVP----LADRERFGQWARGTFDQSDN-- 179 Query: 227 NTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGA 286 + + + + V R+R E DIL++++ ++GA Sbjct: 180 --------------EHSANTFQQVVDYMLELVARKR------VEPGDDILSELIAEKDGA 219 Query: 287 QDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFED 346 D + + G+ET+ + + L R P A+L + Sbjct: 220 LSDADIAHLGNAVLLFGYETTIVRIDLGTLLLLRNPVQRAQLAEDPG------------- 266 Query: 347 LGRLQYLSQVLKESLRL----YPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMD 402 ++E LRL R + + + ++ + D Sbjct: 267 -----LAPAAVEEILRLGVGGKGSNALIPRYAHGDITVGETVIRTGDAVMLAIGAANYDD 321 Query: 403 TYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRL-EFR 461 F D F+ R P ++ F G R CIG+ A++E+ V +L +RL + R Sbjct: 322 RAFPDGGLFDLTRVRP------RSHLAFGHGARHCIGRTLARIELTAVFERLFRRLPDLR 375 Query: 462 L-VPGQRFGLQEQATLKPLDPVLCTL 486 L VP + QE D + T Sbjct: 376 LAVPEESLRWQEHRITGGFDEIPVTF 401 >3RWL-A nrPDB Length = 426 Score = 178 bits (452), Expect = 4e-45, Method: Composition-based stats. Identities = 53/383 (13%), Positives = 124/383 (32%), Gaps = 53/383 (13%) Query: 83 TSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLV-----SECNYERWHKQ 137 +T + + Y + G + G G + + R +Q Sbjct: 63 PYWSITKYNDIMHVDTNHDIFSSDAGYGGIIIDDGIQKGGDGGLDLPNFIAMDRPRHDEQ 122 Query: 138 RRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAF 197 R+ + + ++L +L T E+ + ++ L D ++ + F Sbjct: 123 RKAVSPIVAPANLAALEGTIRERVSKTLDGLPV----GEEFDWVDRVSIEITTQMLATLF 178 Query: 198 GMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDW 257 + G+ S + ++ E+ E + + + + Sbjct: 179 DFPFEERRKLTRWSDVTTAAPGGGVVESWD----------QRKTELLECAAYFQVLWNER 228 Query: 258 VQRRREALKRGEEVPADILTQILKAEEG-AQDDEGLLDNFVTFFIAGHETSANHLAFTVM 316 V + + D+++ + + E L N + + G++T+ N + V+ Sbjct: 229 VNK---------DPGNDLISMLAHSPATRNMTPEEYLGNVLLLIVGGNDTTRNSMTGGVL 279 Query: 317 ELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEE 376 L + P+ A+L+A + ++ E +R P R Sbjct: 280 ALHKNPDQFAKLKANPA------------------LVETMVPEIIRWQTPLAHMRRTAIA 321 Query: 377 ETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRS 436 ++ + G + ++ Y R D + P F DR + F G Sbjct: 322 DSELGGKTIRKGDKVVMWYYSGNRDDEVIDRPEEFIIDR------PRPRQHLSFGFGIHR 375 Query: 437 CIGQQFAQMEVKVVMAKLLQRLE 459 C+G + A+M+++++ ++L R Sbjct: 376 CVGNRLAEMQLRILWEEILTRFS 398 >5LIV-A nrPDB Length = 450 Score = 176 bits (447), Expect = 2e-44, Method: Composition-based stats. Identities = 72/381 (18%), Positives = 139/381 (36%), Gaps = 47/381 (12%) Query: 96 FLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLME 155 L + + T + G ++ + + RRV ++ F ++ E Sbjct: 93 LLRKSHITTAYRDTATFSTRMFQAGILNGGLAAMQGDEHARMRRVYNMFFLPRAVSQYEE 152 Query: 156 T-FNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQA 214 +EQ+V+ L G+ V + + + FG L + Sbjct: 153 RFVRPISEQVVDRL----AGKPRVDLLEDFAMELPRRVIGELFGFPAEKL----HETDER 204 Query: 215 VKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPAD 274 V+ ML G+ + A + E + + + + V+ RE+ + + + Sbjct: 205 VRAMLRGLVRMHDPAA---------VAESQRAYGETLGLITEVVE--RESRDTSDTLLGE 253 Query: 275 ILTQILKAEEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDE 334 IL + LKAE E ++ + G+ET++ +A T+ L P+ +AR++ + Sbjct: 254 IL-RTLKAEHMDTI-EASRQIVLSLILGGYETTSWLVANTIHALLAHPDTLARVRQDP-- 309 Query: 335 VIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFS 394 L ++E +R P ++G R++E + +D + T + + Sbjct: 310 ----------------SLLPAAIEEGMRWCPSSFGVLRMVERDVRLDDQALSAGTVVCLA 353 Query: 395 TYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKL 454 +T + P ++ DR A F G C+G A+ME +V + L Sbjct: 354 GIAGNYDETAYPSPEVYDIDRKPLPAANV------FGGGAHFCVGAPLARMEARVGLQAL 407 Query: 455 LQRLE-FRLVPGQRFGLQEQA 474 L R R VP +R A Sbjct: 408 LARFPGLRAVPEERPSFMYGA 428 >6DCD-A nrPDB Length = 424 Score = 176 bits (446), Expect = 2e-44, Method: Composition-based stats. Identities = 76/455 (16%), Positives = 147/455 (32%), Gaps = 78/455 (17%) Query: 63 VFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTK----------------YNKDS 106 + D+ + PV+R+ + V VT E T + + Sbjct: 21 PYFDYLRSQSPVLRLPQYG--VVAVTGYEEATAVYKDTDSFSNCVALGGPFPPLPFAPNG 78 Query: 107 KMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVE 166 A E+ + + + R ++ + S L E A+ Sbjct: 79 DDVNAQIDAHREQFPMYEHMVTMDPPEHSRARSILSRLLTPSRLKQNEEFMWRLAD---R 135 Query: 167 ILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASR 226 L+ + + A ++A LLG + + + + Sbjct: 136 QLDEFLGAGECEFISEYAKPFATLVIA---------DLLGVPEDDRKDFR-----VVLGA 181 Query: 227 NTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGA 286 + + + + + +++L +++ RR + D+LT + A Sbjct: 182 DRMGRVGALDHESV--GVNPLQWLDDKFSAYIEDRR------RQPRNDVLTALATATYPD 233 Query: 287 QDDEGLLD---NFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLD 343 ++D + F AG ET+A L + L +P+I RL+ Sbjct: 234 GSTPEVIDVVRSATFLFAAGQETTAKLLTAAMRVLGDRPDIQRRLRENR----------- 282 Query: 344 FEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDT 403 + ++ESLR+ P RL + T + G+ + T ++ R Sbjct: 283 -------SLIPNFIEESLRMDSPVKSDSRLARKRTTVGGLDIAAGTVVMVLPGAANRDPR 335 Query: 404 YFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRL----- 458 FEDP F DR + F+ G SC G A++E +V + ++L R+ Sbjct: 336 RFEDPHEFRLDR------PNVREHMAFARGVHSCPGGPLARVEGRVSLERILDRMLDIAI 389 Query: 459 ---EFRLVPGQRFGLQEQATLKPLDPVLCTLRPRG 490 +R+ + L+ L + T P G Sbjct: 390 NEDRHGPADDRRYTYEPTYILRGLTELHITFTPAG 424 >6M7L-A nrPDB Length = 404 Score = 176 bits (445), Expect = 2e-44, Method: Composition-based stats. Identities = 75/463 (16%), Positives = 142/463 (30%), Gaps = 82/463 (17%) Query: 37 PRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNV--FHKTSVIVTSPESVK 94 PR S ++ + + R+ L + GP+VR+ + + V+ Sbjct: 16 PRGSHMVAPE---HRVLHLRDRLDLAAELKLLCERGPLVRIPLEDGSAVHWFALGYDVVR 72 Query: 95 KFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLM 154 + L S K++K G + + + + RR++ A+S + +L Sbjct: 73 EVLGSEKFDKRVIGTHFNHQEMALP----GNLLQLDPPEHTRLRRMVAPAYSVRRMQALE 128 Query: 155 ETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQA 214 + ++ + + G ++++ A + + Sbjct: 129 PRVQAIVDDHLDTMA--STGPPVEFLREVAGPMAARVACE-------------------- 166 Query: 215 VKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPAD 274 + G+ +L R R G ++ RE R P D Sbjct: 167 -----------FLGIPLDDRGELIRLTAHRGGKRRRVLNGHAYLAYMRELAARLRRDPGD 215 Query: 275 ILTQILKAEEGA-QDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVD 333 + ++ + GA DE L + E + + LA + L PE A L+ Sbjct: 216 GMLGMVARDHGADISDEELAGLCAVVMNSSVEQTESCLAAGTLLLLEHPEQFALLRE--- 272 Query: 334 EVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGT-FRLLEEETLIDGVRVPGNTPLL 392 R + Q ++E +R G R E+ I G + + Sbjct: 273 ---------------RPELGEQAVEEIVRYLSVFEGLDPRTATEDVEIGGQVIKKGEAVF 317 Query: 393 FSTYVMGR-MDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVM 451 S R F+ R + F G C+G A+ME+++ Sbjct: 318 CSLLAANRADPAL----DGFDITR-------KESRHVAFGHGIHHCLGAPLARMELRIAF 366 Query: 452 AKLLQRLEFRLVPGQRFGLQ-EQATLKPLDPVLCTL--RPRGW 491 L+ R P R + E+ +P + TL P W Sbjct: 367 TTLVSRF-----PSLRTAVPAEEIRFRPPSSNVFTLLELPLTW 404 >1UED-A nrPDB Length = 406 Score = 175 bits (444), Expect = 3e-44, Method: Composition-based stats. Identities = 60/412 (14%), Positives = 126/412 (30%), Gaps = 69/412 (16%) Query: 69 KKYGPVVRV------NVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFG 122 + +GP+VR+ + E V++ L ++ + ++ Sbjct: 34 RAHGPLVRIVGESSTQLGRDFVWQAHGYEVVRRILGDHEHFTTRPQFTQSKSGAHVEAQF 93 Query: 123 QGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQD 182 G +S + + R+++ F+ + + + +++LEA+ +Q Sbjct: 94 VGQISTYDPPEHTRLRKMLTPEFTVRRIRRMEPAIQSLIDDRLDLLEAEG---PSADLQG 150 Query: 183 MLTYTA-MDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLR 241 + L + ++ + + L+ Sbjct: 151 LFADPVGAHALCELLGIPRDDQREFVRR--------------------IRRNADLSRGLK 190 Query: 242 EVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEG-AQDDEGLLDNFVTFF 300 + + + R+R P D L ++ + G DE L Sbjct: 191 ARAADSAAFNRYLDNLLARQRA-------DPDDGLLGMIVRDHGDNVTDEELKGLCTALI 243 Query: 301 IAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKES 360 + G ET A + F V+ L P + L ++ +V+ E Sbjct: 244 LGGVETVAGMIGFGVLALLDNPGQIELLFESPEK------------------AERVVNEL 285 Query: 361 LRLYPPAWGT-FRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPG 419 +R P RL ++ +IDG + +L S + R + DP + +R Sbjct: 286 VRYLSPVQAPNPRLAIKDVVIDGQLIKAGDYVLCSILMANRDEALTPDPDVLDANRAAVS 345 Query: 420 APKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQ 471 F G C+G A+ +++ L +R PG R + Sbjct: 346 D-------VGFGHGIHYCVGAALARSMLRMAYQTLWRRF-----PGLRLAVP 385 >2NZA-A nrPDB Length = 413 Score = 175 bits (444), Expect = 3e-44, Method: Composition-based stats. Identities = 71/443 (16%), Positives = 144/443 (32%), Gaps = 62/443 (13%) Query: 50 WKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKT--SVIVTSPESVKKFLMSTKYNKDSK 107 W ++ G V + ++ GP+ RV + H + + T + VK ++ + Sbjct: 19 WPALDLDGPEFDPVLAELMRE-GPLTRVRLPHGEGWAWLATRYDDVKAITNDPRFGRAEV 77 Query: 108 MYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEI 167 R + + G ++ + ++ RR + AF+ + L E + LV+ Sbjct: 78 TQRQITRLAPHFKPRPGSLAFADQPDHNRLRRAVAGAFTVGATKRLRPRAQEILDGLVDG 137 Query: 168 LEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRN 227 + P + + + + G+ + Q + G A+ Sbjct: 138 I---LAEGPPADLVERVLEPFPIAVVSEVMGVPAADRERVHSWTRQIIST-SGGAEAAER 193 Query: 228 TLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKA-EEGA 286 + +R R D+ + + A G Sbjct: 194 AKRGLYGWITETVRA------------------------RAGSEGGDVYSMLGAAVGRGE 229 Query: 287 QDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFED 346 + + I G E +++ + L + E++AR++ Sbjct: 230 VGETEAVGLAGPLQIGG-EAVTHNVGQMLYLLLTRRELMARMRERPGAR----------- 277 Query: 347 LGRLQYLSQVLKESLRLYP--PAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTY 404 L E LR + G R+ E+ + G R+ P+ S R Sbjct: 278 -------GTALDELLRWISHRTSVGLARIALEDVEVHGTRIAAGEPVYVSYLAANRDPDV 330 Query: 405 FEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLE-FRL- 462 F DP + DR + + GH C G A+M+ ++++ LL+RL RL Sbjct: 331 FPDPDRIDLDRDPN-------PHLAYGNGHHFCTGAVLARMQTELLVDTLLERLPGLRLA 383 Query: 463 VPGQRFGLQEQATLKPLDPVLCT 485 VP ++ + + ++ + CT Sbjct: 384 VPAEQVAWRRKTMIRGPRTLPCT 406 >3SN5-A nrPDB Length = 491 Score = 175 bits (444), Expect = 4e-44, Method: Composition-based stats. Identities = 90/503 (17%), Positives = 157/503 (31%), Gaps = 63/503 (12%) Query: 24 HRARSRYEHIPGPPRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKT 83 R + P G +P + G L + +K+G V + K Sbjct: 6 SSRRRQTGE------PPLENGLIPYLGCALQFGANPL-EFLRANQRKHGHVFTCKLMGKY 58 Query: 84 SVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDL 143 +T+P S K L KY ++ + FG + + Sbjct: 59 VHFITNPLSYHKVLCHGKY----FDWKKFHFALSAKAFGHRSIDPMDGNTTENINDTFIK 114 Query: 144 AFSRSSLVSLMETFNEKAEQLVE---ILEAKADGQTPVSMQDMLTYTAMDILAKAAFGME 200 +L SL E+ E ++++ +K M + FG + Sbjct: 115 TLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFGRD 174 Query: 201 TSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQR 260 L + + L+ + G + R + ++ Sbjct: 175 ----LTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPIHM--FRTAHNAREKLAESL--- 225 Query: 261 RREALKRGEEVPADILTQILKAEE-GAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELS 319 R E L++ E + I ++ + DD + A + +++ ++ Sbjct: 226 RHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMI 285 Query: 320 RQPEIVARLQAEVDEVI----------GSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWG 369 R PE + EV + G+ L +L L L ++KESLRL + Sbjct: 286 RNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLN 345 Query: 370 TFRLLEEETLI----DGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDR---------- 415 R +E+ + + + + +M + DPLTF DR Sbjct: 346 I-RTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKT 404 Query: 416 -FGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQA 474 F K ++ Y PF G C G+ FA E+K + +L E L+ GQ A Sbjct: 405 TFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQ-------A 457 Query: 475 TLKPLDPVLCTLRPRGWQPAPPP 497 PLD + R PP Sbjct: 458 KCPPLD------QSRAGLGILPP 474 >6F88-A nrPDB Length = 400 Score = 175 bits (443), Expect = 4e-44, Method: Composition-based stats. Identities = 72/381 (18%), Positives = 138/381 (36%), Gaps = 47/381 (12%) Query: 96 FLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLME 155 L + + T + G ++ + + RRV ++ F ++ E Sbjct: 43 LLRKSHITTAYRDTATFSTRMFQAGILNGGLAAMQGDEHARMRRVYNMFFLPRAVSQYEE 102 Query: 156 T-FNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQA 214 +EQ+V+ L G+ V + + + FG L + Sbjct: 103 RFVRPISEQVVDRL----AGKPRVDLLEDFAMELPRRVIGELFGFPAEKL----HETDER 154 Query: 215 VKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPAD 274 V+ ML G+ + A + E + + + + V+ RE+ + + + Sbjct: 155 VRAMLRGLVRMHDPAA---------VAESQRAYGETLGLITEVVE--RESRDTSDTLLGE 203 Query: 275 ILTQILKAEEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDE 334 IL + LKAE E ++ + G+ET++ +A T+ L P+ +AR++ + Sbjct: 204 IL-RTLKAEHMDTI-EASRQIVLSLILGGYETTSWLVANTIHALLAHPDTLARVRQDP-- 259 Query: 335 VIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFS 394 L ++E +R P +G R++E + +D + T + + Sbjct: 260 ----------------SLLPAAIEEGMRWCPSNFGVLRMVERDVRLDDQALSAGTVVCLA 303 Query: 395 TYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKL 454 +T + P ++ DR A F G C+G A+ME +V + L Sbjct: 304 GIAGNYDETAYPSPEVYDIDRKPLPAANV------FGGGAHFCVGAPLARMEARVGLQAL 357 Query: 455 LQRLE-FRLVPGQRFGLQEQA 474 L R R VP +R A Sbjct: 358 LARFPGLRAVPEERPSFMYGA 378 >5DQN-A nrPDB Length = 426 Score = 174 bits (441), Expect = 8e-44, Method: Composition-based stats. Identities = 60/435 (13%), Positives = 136/435 (31%), Gaps = 73/435 (16%) Query: 43 LGHLPCFWKKDEVGGRVLQDVFLDWA--KKYGPVVRVNVFHKTS-------VIVTSPESV 93 ++P + + + + + A +K P+ V+V T +VT V Sbjct: 3 TPNIPSDFDFLDATLNLERLPVEELAELRKSEPIHWVDVPGGTGGFGDKGYWLVTKHADV 62 Query: 94 KKFLMSTKYNKDSKMYRALQTVFGERLFG------QGLVSECNYERWHKQRRVIDLAFSR 147 K+ +S + + V+ + + + ++ + + + R++I F+ Sbjct: 63 KE--VSRRSDVFGSSPDGAIPVYPQDMTREAVDLQRAVLLNMDAPQHTRLRKIISRGFTP 120 Query: 148 SSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGA 207 ++ L + + + + A Q + ++ G+ Sbjct: 121 RAIGRLED----ELRSRAQKIAQTAAAQGAGDFVEQVSCELPLQAIAELLGVPQDDRDKL 176 Query: 208 QKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKR 267 + ++ ++ F + A +R Sbjct: 177 FRWSNEMTAGEDPEYADVDPAMSSF----------------------ELISYAMKMAEER 214 Query: 268 GEEVPADILTQILKAEEGA--QDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIV 325 DI+T++++A+ D+ V +AG+ET+ N + ++ ++ P+ Sbjct: 215 AVNPTEDIVTKLIEADIDGEKLSDDEFGFFVVMLAVAGNETTRNSITHGMIAFAQNPDQW 274 Query: 326 ARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRV 385 + E E E +R P R E+ + GV++ Sbjct: 275 ELYKKERPE--------------------TAADEIVRWATPVSAFQRTALEDVELGGVQI 314 Query: 386 PGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSL-GHRSCIGQQFAQ 444 ++ S + FEDP TFN R + F G CIG A+ Sbjct: 315 KKGQRVVMSYRSANFDEEVFEDPHTFNILRSPN-------PHVGFGGTGAHYCIGANLAR 367 Query: 445 MEVKVVMAKLLQRLE 459 M + ++ + + Sbjct: 368 MTINLIFNAIADNMP 382 >5DE9-A nrPDB Length = 410 Score = 173 bits (439), Expect = 1e-43, Method: Composition-based stats. Identities = 71/444 (15%), Positives = 148/444 (33%), Gaps = 64/444 (14%) Query: 50 WKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKT--SVIVTSPESVKKFLMSTKYNKDSK 107 W ++ G V + ++ GPV R+++ + + +VT + V+ ++ +++ Sbjct: 16 WPAVDLPGSDFDPVLTELMRE-GPVTRISLPNGEGWAWLVTRHDDVRLVTNDPRFGREAV 74 Query: 108 MYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEI 167 M R + + +G V + + RR + AF+ + + E ++LV+ Sbjct: 75 MDRQVTRLAPHFRPARGAVGFLDPPDHTRLRRSVAAAFTARGVERVRERSRGMLDELVDA 134 Query: 168 LEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRN 227 + P + + + + G+ + Q + G S Sbjct: 135 M---LRAGPPADLTEAVLSPFPIAVICELMGVPATDRHSMHTWT-QLILSSSHGAEVSE- 189 Query: 228 TLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKA-EEGA 286 + + D + R + D+ + + A Sbjct: 190 -----------------RAKNEMNAYFSDLIGLR------SDSAGEDVTSLLGAAVGRDE 226 Query: 287 QDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFED 346 + V I G E N+ L +PE+ RL++E + Sbjct: 227 ITLSEAVGLAVLLQIGG-EAVTNNSGQMFHLLLSRPELAERLRSEPEIR----------- 274 Query: 347 LGRLQYLSQVLKESLRLYP--PAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTY 404 + + E LR P A G R+ E+ I GVR+ + S R Sbjct: 275 -------PRAIDELLRWIPHRNAVGLSRIALEDVEIKGVRIRAGDAVYVSYLAANRDPEV 327 Query: 405 FEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQR---LEFR 461 F DP + +R + F G C G A++E ++++ +L R L+ Sbjct: 328 FPDPDRIDFERSPN-------PHVSFGFGPHYCPGGMLARLESELLVDAVLDRVPGLKLA 380 Query: 462 LVPGQRFGLQEQATLKPLDPVLCT 485 + P + ++ A ++ + + T Sbjct: 381 VAP-EDVPFKKGALIRGPEALPVT 403 >2FR7-A nrPDB Length = 412 Score = 173 bits (439), Expect = 1e-43, Method: Composition-based stats. Identities = 82/459 (17%), Positives = 149/459 (32%), Gaps = 57/459 (12%) Query: 33 IPGPPRPSFLLGHLPCFWKKDEVGGRVLQDVF--LDWAKKYGPVVRVNVFHKTSVIVTSP 90 + PS +P D D + + ++ GPV V + V Sbjct: 7 LVPVTTPSQHGAGVPHLG-IDPFALDYFADPYPEQETLREAGPV--VYLDKWNVYGVARY 63 Query: 91 ESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSL 150 V L S+ + L+ E + + R V+ S +++ Sbjct: 64 AEVYAVLNDPLTFCSSRGVGLSDFKKEKPWRPPSLILEADPPAHTRTRAVLSKVLSPATM 123 Query: 151 VSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKP 210 L + F A+ ++ L A+ +D +A A S+ A Sbjct: 124 KRLRDGFAAAADAKIDELLARGGN--------------IDAIADLAEAYPLSVFPDAMGL 169 Query: 211 LSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEE 270 + + +L N E+R+S + +V E +R Sbjct: 170 KQEGRENLLPYAGLVFNAFGP--------PNELRQSAIERSAPHQAYVA---EQCQRPNL 218 Query: 271 VPADILTQILK-AEEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQ 329 P I ++ G E + AG +T+ N +A V L+R P+ ARL+ Sbjct: 219 APGGFGACIHAFSDTGEITPEEAPLLVRSLLSAGLDTTVNGIAAAVYCLARFPDEFARLR 278 Query: 330 AEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNT 389 A+ +E++R P FR + + G + Sbjct: 279 ADP------------------SLARNAFEEAVRFESPVQTFFRTTTRDVELAGATIGEGE 320 Query: 390 PLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKV 449 +L R ++DP ++ R G + F G C+GQ A++E +V Sbjct: 321 KVLMFLGSANRDPRRWDDPDRYDITRKTSG-------HVGFGSGVHMCVGQLVARLEGEV 373 Query: 450 VMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPVLCTLRP 488 V+A L +++ + G + TL+ L+ + L P Sbjct: 374 VLAALARKVAAIEIAGP-LKRRFNNTLRGLESLPIQLTP 411 >6HQG-A nrPDB Length = 425 Score = 172 bits (436), Expect = 3e-43, Method: Composition-based stats. Identities = 51/367 (13%), Positives = 123/367 (33%), Gaps = 43/367 (11%) Query: 125 LVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDML 184 + + + QR+ + + + L L E+A ++++ L ++ D + Sbjct: 101 MFIAMDPPKHDVQRKTVQPIVAPNHLAYLEPIIRERAGKILDDLPI----GEEINWVDKV 156 Query: 185 TYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVR 244 + + F A GI + + P + + LR + Sbjct: 157 SIELTTMTLATLFDFPWEDRRKLTFWSDVATSAPESGILGTTD------PEEHENLRR-Q 209 Query: 245 ESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEE-GAQDDEGLLDNFVTFFIAG 303 + R W +R K D+++ + E D L N + + G Sbjct: 210 TLFECVDYFMRLWNERVNAPPKP------DLISMLAHGESTKNMDRMEYLGNLILLIVGG 263 Query: 304 HETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRL 363 ++T+ N ++ +V+ L + P+ +L+ + ++ E++R Sbjct: 264 NDTTRNTISGSVLALHQNPDQDRKLRENPG------------------LIPAMVSETIRW 305 Query: 364 YPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKP 423 P R + + + G + + R + + P + +R Sbjct: 306 QTPLAYMRRRAKRDFELGGKTIREGDKVAMWYVSGNRDEEVIDRPNDYWIER------PR 359 Query: 424 RFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPVL 483 + F G C+G + A++++K++ ++L R V G + + +K + + Sbjct: 360 VRQHLSFGFGVHRCVGNRLAELQLKIIWEEILARFPRLEVVGPPRRV-YSSFVKGYEELP 418 Query: 484 CTLRPRG 490 + R Sbjct: 419 VVIPTRN 425 >6FSH-A nrPDB Length = 398 Score = 171 bits (433), Expect = 7e-43, Method: Composition-based stats. Identities = 58/411 (14%), Positives = 123/411 (29%), Gaps = 60/411 (14%) Query: 82 KTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQ----GLVSECNYERWHKQ 137 +T+ + V++ L + + + + G+ +F G + + + + Sbjct: 40 ETTWLAAGHAVVRQVLGDHQQFSTRRRWDPRDEIGGKGIFRPRELVGNLMDYDPPEHTRL 99 Query: 138 RRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAF 197 R ++ F++ + L E + L+A P + ++ Sbjct: 100 RHLLTPGFTQRRMRRLAPRIEEIV---TDRLDAMEQAGPPADLIELFADEVP-------- 148 Query: 198 GMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDW 257 G L+G + + G L Q R +F R + Sbjct: 149 GAVLCELIGVPRDDRDMFMKLCHG----------HLDASLSQKRRAALGDKFSRYLLAMI 198 Query: 258 VQRRREALKRGEEVPADILTQILKAEEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVME 317 + R+ + + I+ DE L V +AG + + + V+ Sbjct: 199 ARERK-------DPGDGFIGSIVAEHGDTITDEELRGVCVQLMLAGDDNVSGMIGLGVLA 251 Query: 318 LSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYP-PAWGTFRLLEE 376 L R PE +A L+ + + + E +R P T R E Sbjct: 252 LLRHPEQIAALRGDDQS------------------ADRAVDELIRYLTVPYAPTPRTAVE 293 Query: 377 ETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRS 436 + ++ + +L S + R D + R + F G Sbjct: 294 DVMVADQVIKEGETVLCSLPMANRDRALLPDADRLDVTR-------TPVPHVAFGHGIHH 346 Query: 437 CIGQQFAQMEVKVVMAKLLQRLEFRLV--PGQRFGLQEQATLKPLDPVLCT 485 C+G ++++++ L +R + P Q + L +L Sbjct: 347 CLGAALTRLQLRIAYTALWRRFPALQLADPAQEIMFRTSTPAYGLTSLLVA 397 >6F0B-A nrPDB Length = 395 Score = 170 bits (431), Expect = 1e-42, Method: Composition-based stats. Identities = 58/411 (14%), Positives = 139/411 (33%), Gaps = 59/411 (14%) Query: 81 HKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGL-VSECNYERWHKQRR 139 + + + E V+ L +++ DS+ + + + + R Sbjct: 37 GTPAHVFSGYEDVRTVLQDRRFSSDSRRPNFTELTPTLQSQAAAPPFVRTDNPDHRRLRG 96 Query: 140 VIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGM 199 I F + L E + +++ L A P M + + + F Sbjct: 97 TIAREFLPKHIELLRPAIREIVQGVLDGLAETA---PPQDMLEAFAVP---VASATVF-- 148 Query: 200 ETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQ 259 LLG + ++G+ ++ E E R L + VQ Sbjct: 149 ---RLLGIPAEDRALLTRCVKGVVSAVG-----------SEDEGAEVFRTLGEYIGGLVQ 194 Query: 260 RRREALKRGEEVPADILTQILKA--EEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVME 317 E ++ +++ +E + + + G++T+A+ ++ +++ Sbjct: 195 ------DPSELPEDSLIRRLVTGPYQEKQLTFHETIGVILMLIVGGYDTTASTISLSLVS 248 Query: 318 LSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPA-WGTFRLLEE 376 + QPE + + + + +++E LR + + G R+ E Sbjct: 249 YALQPEKFSVVHEHPER------------------IPLLVEELLRYHTVSQLGLGRIATE 290 Query: 377 ETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRS 436 + + GV V ++ + + R ++ F +P + DR P + F G Sbjct: 291 DVEVGGVTVRAGQMVVAALPLANRDESVFPNPDELDFDR-------PSVPHVGFGYGPHQ 343 Query: 437 CIGQQFAQMEVKVVMAKLLQRLEFRLV--PGQRFGLQEQATLKPLDPVLCT 485 C+GQ A++E++ + +++RL + + + + + T Sbjct: 344 CVGQALARVELQEAIPAVIRRLPGMRLACALEDLPFRHDMATYGIHELPMT 394 >1F4U-A nrPDB Length = 368 Score = 170 bits (430), Expect = 1e-42, Method: Composition-based stats. Identities = 70/438 (15%), Positives = 140/438 (31%), Gaps = 79/438 (18%) Query: 60 LQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGER 119 + D F + KK PV + V S K+ L ++K S + Sbjct: 1 MYDWFSEMRKK-DPVY--YDGN--IWQVFSYRYTKEVL--NNFSKFSSDLTGYHERLEDL 53 Query: 120 LFGQ--------GLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAK 171 G+ + + + R + FS L +L E L++ ++ + Sbjct: 54 RNGKIRFDIPTRYTMLTSDPPLHDELRSMSADIFSPQKLQTLETFIRETTRSLLDSIDPR 113 Query: 172 ADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAK 231 D + L I+ G+ + L Sbjct: 114 ED-----DIVKKLAVPLPIIVISKILGLPIEDKEK----------------FKEWSDLVA 152 Query: 232 FLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDEG 291 F GK ++ E+ + L +D + +++++++ + D Sbjct: 153 FRLGKPGEIFELGKKYLELIGYVKDHL-----------NSGTEVVSRVVNS---NLSDIE 198 Query: 292 LLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQ 351 L + IAG+ET+ N ++ +V++ +R + R++ E Sbjct: 199 KLGYIILLLIAGNETTTNLISNSVIDFTRF-NLWQRIREE-------------------N 238 Query: 352 YLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTF 411 + ++E+LR PP T R +E + + + R + F D F Sbjct: 239 LYLKAIEEALRYSPPVMRTVRKTKERVKLGDQTIEEGEYVRVWIASANRDEEVFHDGEKF 298 Query: 412 NPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQ 471 PDR P P + F G C+G A++E ++ + + +R R + Sbjct: 299 IPDR----NPNP---HLSFGSGIHLCLGAPLARLEARIAIEEFSKRF--RHIEILDTEKV 349 Query: 472 EQATLKPLDPVLCTLRPR 489 L ++ L+ Sbjct: 350 PNEVLNGYKRLVVRLKSN 367 >4TX3-A nrPDB Length = 404 Score = 170 bits (430), Expect = 1e-42, Method: Composition-based stats. Identities = 56/411 (13%), Positives = 122/411 (29%), Gaps = 60/411 (14%) Query: 82 KTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQ----GLVSECNYERWHKQ 137 +T+ + V++ L K + + + G +F G + + + + Sbjct: 46 ETTWLAAGHAVVRQVLGDHKRFSTRRRFDRRDEIGGTGVFRPRELVGNLMDYDPPEHTRL 105 Query: 138 RRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAF 197 R ++ F++ + L E + L+A P + ++ + Sbjct: 106 RHLLTPGFTQRRMRRLAPRIEEIV---TDRLDAMEQAGPPADLIELFADEVPGAVLCELI 162 Query: 198 GMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDW 257 G+ Q Q L+ ++ R+ + + Sbjct: 163 GVPRD----DQAMFLQLCHRHLDASLSA---------------RKRAAAGEAFARYLVAM 203 Query: 258 VQRRREALKRGEEVPADILTQILKAEEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVME 317 + R R+ + + I+ DE L V +AG + + + V+ Sbjct: 204 MARERK------DPGDGFIGSIVAEHGDTITDEELRGVCVQLMLAGDDNVSGMIGLGVLA 257 Query: 318 LSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYP-PAWGTFRLLEE 376 L R PE +A L+ + + + E +R P T R E Sbjct: 258 LLRHPEQIAALRGDDQS------------------ADRAVDELIRYLTVPYAPTPRTAVE 299 Query: 377 ETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRS 436 + ++ + +L S + R D + R + F G Sbjct: 300 DVMVADQVIKEGETVLCSLPMANRDRALLPDADRLDVTR-------TPVPHVAFGHGIHH 352 Query: 437 CIGQQFAQMEVKVVMAKLLQRLEFRLV--PGQRFGLQEQATLKPLDPVLCT 485 C+G ++++++ L +R + P Q + L +L Sbjct: 353 CLGAALTRLQLRIAYTALWRRFPALQLADPAQEIMFRTSTPAYGLTSLLVA 403 >1LG9-A nrPDB Length = 398 Score = 169 bits (429), Expect = 2e-42, Method: Composition-based stats. Identities = 58/425 (13%), Positives = 130/425 (30%), Gaps = 64/425 (15%) Query: 72 GPVVRVNVFH----KTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQ---- 123 G + RV + +T + T+ V++ + + + + + G+ +F Sbjct: 26 GALTRVTIGSGADAETHWMATAHAVVRQVMGDHQQFSTRRRWDPRDEIGGKGIFRPRELV 85 Query: 124 GLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDM 183 G + + + + RR + F+ + + + ++ +E D+ Sbjct: 86 GNLMDYDPPEHTRLRRKLTPGFTLRKMQRMAPYIEQIVNDRLDEMERAGS------PADL 139 Query: 184 LTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREV 243 + + A + L+G + + G L Q R Sbjct: 140 IAFVADKVPGAVL-----CELVGVPRDDRDMFMKLCHG----------HLDASLSQKRRA 184 Query: 244 RESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDEGLLDNFVTFFIAG 303 +F R + + R+E ++ ++ DE L V +AG Sbjct: 185 ALGDKFSRYLLAMIARERKE-------PGEGMIGAVVAEYGDDATDEELRGFCVQVMLAG 237 Query: 304 HETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRL 363 + + + V+ + R PE + + + + + E +R Sbjct: 238 DDNISGMIGLGVLAMLRHPEQIDAFRGDEQS------------------AQRAVDELIRY 279 Query: 364 YP-PAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPK 422 P T R+ E+ + G + ++ S R D + R Sbjct: 280 LTVPYSPTPRIAREDLTLAGQEIKKGDSVICSLPAANRDPALAPDVDRLDVTR------- 332 Query: 423 PRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLV--PGQRFGLQEQATLKPLD 480 + F G C+G A++E++ V +L +R + P Q + L Sbjct: 333 EPIPHVAFGHGVHHCLGAALARLELRTVFTELWRRFPALRLADPAQDTEFRLTTPAYGLT 392 Query: 481 PVLCT 485 ++ Sbjct: 393 ELMVA 397 >5FYF-A nrPDB Length = 470 Score = 168 bits (426), Expect = 4e-42, Method: Composition-based stats. Identities = 57/413 (13%), Positives = 145/413 (35%), Gaps = 53/413 (12%) Query: 83 TSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGL--VSECNYERWHKQRRV 140 VT E + + ++ S Q + G+ G + + + QR Sbjct: 104 PFWSVTRFEDI--LFVDKSHDLFS---AEPQIILGDPPEGLSVEMFIAMDPPKHDVQRSS 158 Query: 141 IDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGME 200 + + +L + + +++ L P + ++K G Sbjct: 159 VQGVVAPKNLKEMEGLIRSRTGDVLDSLPT----DKPFNWVPA--------VSKELTGRM 206 Query: 201 TSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQR 260 + LL + + + + + + + + R ++ RD R Sbjct: 207 LATLLDFPYEERHKLVEWSDRMAGAASATGGEFADENAMFDDAADMARSFSRLWRDKEAR 266 Query: 261 RREALKRGEEVPADILTQILKAEEGAQD----DEGLLDNFVTFFIAGHETSANHLAFTVM 316 R GEE D+++ +L++ + +D + N + G++T+ N ++ ++ Sbjct: 267 RAA----GEEPGFDLIS-LLQSNKETKDLINRPMEFIGNLTLLIVGGNDTTRNSMSGGLV 321 Query: 317 ELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEE 376 ++ P +L+A + + + ++ E +R P R+ ++ Sbjct: 322 AMNEFPREFEKLKA------------------KPELIPNMVSEIIRWQTPLAYMRRIAKQ 363 Query: 377 ETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRS 436 + + G + ++ R + F++P F DR K + F G Sbjct: 364 DVELGGQTIKKGDRVVMWYASGNRDERKFDNPDQFIIDR------KDARNHMSFGYGVHR 417 Query: 437 CIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPVLCTLRPR 489 C+G + A+++++++ ++L+R + V + +Q + ++ L P Sbjct: 418 CMGNRLAELQLRILWEEILKRFDNIEVVEEPERVQSNFV-RGYSRLMVKLTPN 469 >5HDI-A nrPDB Length = 404 Score = 167 bits (424), Expect = 6e-42, Method: Composition-based stats. Identities = 65/391 (16%), Positives = 129/391 (32%), Gaps = 60/391 (15%) Query: 78 NVFHKTSVIVTSPESVKKFLMSTK-----------YNKDSKMYRALQTVFGERLFGQGLV 126 + + V ++V + + + Y + G ++ Sbjct: 34 RIANSDFYAVCGWDAVNEAIGRPEDFSSNLTATMTYTAEGTAKPFEMDPLGGPTH---VL 90 Query: 127 SECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTY 186 + + R+++ + + + + + A + L + + Sbjct: 91 ATADDPAHAVHRKLVLRHLAAKRIRVMEQFTVQAA----DRLWVDGMQDGCIEWMGAMAN 146 Query: 187 TAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRES 246 ++ G+ + K A +LEG+ + +A Sbjct: 147 RLPMMVVAELIGLPDPDIAQLVKW-GYAATQLLEGLVENDQLVA--------------AG 191 Query: 247 IRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDEGLLDNFVTFFIAGHET 306 + + G + Q R A + + ++ T E + VT F AG E+ Sbjct: 192 VALMELSGYIFEQFDRAAADPRDNLLGELATACASGELDTLTAQ---VMMVTLFAAGGES 248 Query: 307 SANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPP 366 +A L V L+ +P+I +++A + L ++E+LR PP Sbjct: 249 TAALLGSAVWILATRPDIQQQVRANPE------------------LLGAFIEETLRYEPP 290 Query: 367 AWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFT 426 G +R + T +DG +P ++ LL R FE P F DR G Sbjct: 291 FRGHYRHVRNATTLDGTELPADSHLLLLWGAANRDPAQFEAPGEFRLDRAGGKG------ 344 Query: 427 YFPFSLGHRSCIGQQFAQMEVKVVMAKLLQR 457 + F G C+G A++E ++V+ LL R Sbjct: 345 HISFGKGAHFCVGAALARLEARIVLRLLLDR 375 >2RFC-A nrPDB Length = 343 Score = 167 bits (424), Expect = 7e-42, Method: Composition-based stats. Identities = 64/405 (15%), Positives = 133/405 (32%), Gaps = 76/405 (18%) Query: 84 SVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSE--CNYERWHKQRRVI 141 + V VK LM+ K + G R G +S + + R + Sbjct: 12 AWHVYKYSDVKHVLMNDKIFSSNP---------GNRYSNAGGISFITMDNPEHKEFRDIS 62 Query: 142 DLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMET 201 F S + + E + L++ ++ K + + ++I++K Sbjct: 63 APYFLPSKINDYKDFIEETSNDLIKNIDNK------DIISEYAVRLPVNIISKIL----- 111 Query: 202 SMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRR 261 GI S L K + E+ ++ V R Sbjct: 112 -------------------GIPDSDMPLFKLWSDYIIG-NKRDENFNYVNN---RMVSRL 148 Query: 262 REALKRGEEVPADILTQILKAEEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQ 321 E K ++L DE + + I G+ET+ N + + + Sbjct: 149 LEIFKSDSHGIINVLAGSSLKNRKLTMDEKIKY-IMLLIIGGNETTTNLIGNMIRVIDEN 207 Query: 322 PEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGT-FRLLEEETLI 380 P+I +D+ + ++ S ++E+LR Y P R E++ I Sbjct: 208 PDI-------IDDALKNR--------------SGFVEETLRYYSPIQFLPHRFAAEDSYI 246 Query: 381 DGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQ 440 + ++ ++ R +T+F++P F R R + F +G C+G Sbjct: 247 NNKKIKKGDQVIVYLGSANRDETFFDEPDLFKIGR--------REMHLAFGIGIHMCLGA 298 Query: 441 QFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPVLCT 485 A++E + + +L + + ++ L + + D + + Sbjct: 299 PLARLEASIALNDILNHFKRIKIDYKKSRLLDNKMVLGYDKLFLS 343 >1Q5D-A nrPDB Length = 419 Score = 167 bits (422), Expect = 1e-41, Method: Composition-based stats. Identities = 64/424 (15%), Positives = 131/424 (30%), Gaps = 62/424 (14%) Query: 73 PVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERL----FGQGLVSE 128 P+ + S ++T V ++ + + + + + Sbjct: 40 PIFYWDEG--RSWVLTRYHDVSAVFRDERFAVSREEWESSAEYSSAIPELSDMKKYGLFG 97 Query: 129 CNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTA 188 E + R++++ +F+ ++ L +QL++ + + + + A Sbjct: 98 LPPEDHARVRKLVNPSFTSRAIDLLRAEIQRTVDQLLDARSGQEEFDVVRDYAEGIPMRA 157 Query: 189 MDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIR 248 + LL + + G +R +P ++ + + S+ Sbjct: 158 ISA------------LLKVPAECDEKFRRF--GSATARALGVGLVPRVDEETKTLVASVT 203 Query: 249 FLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGA--QDDEGLLDNFVTFFIAGHET 306 + + RR + D+LT +L+AE + L+ AG +T Sbjct: 204 EGLALLHGVLDERR-----RNPLENDVLTMLLQAEADGSRLSTKELVALVGAIIAAGTDT 258 Query: 307 SANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPP 366 + +AF V+ L R PE + ++AE + L E LR Sbjct: 259 TIYLIAFAVLNLLRSPEALELVKAEPG------------------LMRNALDEVLRFDNI 300 Query: 367 A-WGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRF 425 GT R ++ G + + R T F P F+ R + Sbjct: 301 LRIGTVRFARQDLEYCGASIKKGEMVFLLIPSALRDGTVFSRPDVFDVRRDTSAS----- 355 Query: 426 TYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLE---------FRLVPGQRFGLQEQATL 476 + G C G A++E ++ + + +R F P R L Sbjct: 356 --LAYGRGPHVCPGVSLARLEAEIAVGTIFRRFPEMKLKETPVFGYHPAFRNIESLNVIL 413 Query: 477 KPLD 480 KP Sbjct: 414 KPSK 417 >6HQW-A nrPDB Length = 445 Score = 167 bits (422), Expect = 1e-41, Method: Composition-based stats. Identities = 48/334 (14%), Positives = 116/334 (34%), Gaps = 48/334 (14%) Query: 125 LVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDML 184 + + QRR + AF+ + +V + + +++ L D + Sbjct: 128 MFIAMDRPDHTGQRRTVAPAFTPAKMVEMEAEIRRRTASVLDSLPW----GERFDWVDKV 183 Query: 185 TYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVR 244 + + FG + + + + TLA+ L R Sbjct: 184 SIELTTGMLAILFGFPWADR--------RLLTFWSDWAGDVELTLARELADTR------- 228 Query: 245 ESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGA-QDDEGLLDNFVTFFIAG 303 FL ++ + +R + D+++ ++ +E + + N V + G Sbjct: 229 --FGFLGEMAHYF--QRLWGARMQAPPSGDLISMMIHSEAMNHMSPQEFMGNLVLLIVGG 284 Query: 304 HETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRL 363 ++T+ N ++ V L + P+ L+ + + ++E +R Sbjct: 285 NDTTRNTMSGIVHALDKFPDQRELLERDA------------------SLIPNAVQECIRY 326 Query: 364 YPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKP 423 P R +T + G ++ ++ R +T FE+P DR Sbjct: 327 VTPLAHMRRTATADTELFGNQIKAGEKVILWYISANRDETVFENPDKLMVDR------PN 380 Query: 424 RFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQR 457 + F G C+G + A++++++++ ++ +R Sbjct: 381 ARRHLSFGHGIHRCVGARLAELQLRILLEEMHER 414 >4DO1-A nrPDB Length = 410 Score = 166 bits (421), Expect = 2e-41, Method: Composition-based stats. Identities = 66/418 (15%), Positives = 130/418 (31%), Gaps = 55/418 (13%) Query: 72 GPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNY 131 GPV V + V V L S+ + L+ E + Sbjct: 46 GPV--VYLDKWNVYGVARYAEVHAVLNDPTTFCSSRGVGLSDFKKEKPWRPPSLILEADP 103 Query: 132 ERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDI 191 + R V+ S +++ ++ + F A+ V+ L + + + + Sbjct: 104 PAHTRPRAVLSKVLSPATMKTIRDGFAAAADAKVDELLQRGCIDAIADLAEAYPLSV--- 160 Query: 192 LAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLR 251 A G++ A + E+R++ Sbjct: 161 -FPDAMGLKQEGREHL-------------------LPYAGLVFNAFGPPNELRQTAIERS 200 Query: 252 QVGRDWVQRRREALKRGEEVPADILTQILK-AEEGAQDDEGLLDNFVTFFIAGHETSANH 310 + +V E +R P I + G + + AG +T+ N Sbjct: 201 APHQAYVN---EQCQRPNLAPGGFGACIHAFTDTGEITPDEAPLLVRSLLSAGLDTTVNG 257 Query: 311 LAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGT 370 + V L+R P + RL+++ +E++R P Sbjct: 258 IGAAVYCLARFPGELQRLRSDP------------------TLARNAFEEAVRFESPVQTF 299 Query: 371 FRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPF 430 FR E + G + +L R + DP ++ R G + F Sbjct: 300 FRTTTREVELGGAVIGEGEKVLMFLGSANRDPRRWSDPDLYDITRKTSG-------HVGF 352 Query: 431 SLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPVLCTLRP 488 G C+GQ A++E +V+++ L +++ + G + TL+ L+ + L P Sbjct: 353 GSGVHMCVGQLVARLEGEVMLSALARKVAAIDIDGP-VKRRFNNTLRGLESLPVKLTP 409 >4FB2-A nrPDB Length = 398 Score = 166 bits (419), Expect = 2e-41, Method: Composition-based stats. Identities = 67/388 (17%), Positives = 131/388 (33%), Gaps = 59/388 (15%) Query: 85 VIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLA 144 +V + ++ + +TK + + L G + K R+++ Sbjct: 47 WVVAGYKEIQAVIQNTKAFSNKGVTFPRYETGEFELMMAG----QDDPVHKKYRQLVAKP 102 Query: 145 FSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSML 204 FS + E + L++ +G D T+ A +I A+ T++L Sbjct: 103 FSPEATDLFTEQLRQSTNDLIDARIELGEG-------DAATWLANEIPARL-----TAIL 150 Query: 205 LGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREA 264 LG + + IT N E E L R + RR Sbjct: 151 LGLPPEDGDTYRRWVWAITHVENP------------EEGAEIFAELVAHARTLIAERR-- 196 Query: 265 LKRGEEVPADILTQILKAEEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEI 324 G ++ + ++ + E ++DD L+ F + G + +A L+ L+ E+ Sbjct: 197 TNPGNDIMSRVIMSKIDGESLSEDD--LIGFFTILLLGGIDNTARFLSSVFWRLAWDIEL 254 Query: 325 VARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVR 384 RL + + + + E LR Y PA RL+ +E + + Sbjct: 255 RRRL------------------IAHPELIPNAVDELLRFYGPAM-VGRLVTQEVTVGDIT 295 Query: 385 VPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQ 444 + + + R + F+ P +R + G C+G + Sbjct: 296 MKPGQTAMLWFPIASRDRSAFDSPDNIVIER-------TPNRHLSLGHGIHRCLGAHLIR 348 Query: 445 MEVKVVMAKLLQRL-EFRLVPGQRFGLQ 471 +E +V + + L+R+ EF L P + Sbjct: 349 VEARVAITEFLKRIPEFSLDPNKECEWL 376 >3A1L-A nrPDB Length = 425 Score = 164 bits (416), Expect = 5e-41, Method: Composition-based stats. Identities = 59/386 (15%), Positives = 120/386 (31%), Gaps = 54/386 (13%) Query: 80 FHKTSVIVTSPESVKKFLMSTKYNKDSKMYRA---------LQTVFGERLFGQGLVSECN 130 + V + + V + L + + +++++ R + + + Sbjct: 43 GKPDTYYVFTYDDVVRVLSNRRLGRNARVASGDTDTAPVPIPTEHRALRTVVENWLVFLD 102 Query: 131 YERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMD 190 + R ++ FS S + L E A L++ L A+ + + Sbjct: 103 PPHHTELRSLLTTEFSPSIVTGLRPRIAELASALLDRLRAQRRP----DLVEGFAAPLPI 158 Query: 191 ILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFL 250 ++ A G + ++ + + T A+ G + +E R+ Sbjct: 159 LVISALLG--------IPEEDHTWLRANAVALQEASTTRARDGRGYARAEAASQEFTRYF 210 Query: 251 RQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDEGLLDNFVTFFIAGHETSANH 310 R+ R+ L D +G++ V AGHET+ N Sbjct: 211 RREVDRRGGDDRDDLLTLLVRARD--------TGSPLSVDGIVGTCVHLLTAGHETTTNF 262 Query: 311 LAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGT 370 LA V+ L +++ L+ + ++E +R PP Sbjct: 263 LAKAVLTLRAHRDVLDELRTTPES------------------TPAAVEELMRYDPPVQAV 304 Query: 371 FRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPF 430 R E+ + +P + ++ R F DP + R F Sbjct: 305 TRWAYEDIRLGDHDIPRGSRVVALLGSANRDPARFPDPDVLDVHRAAERQ-------VGF 357 Query: 431 SLGHRSCIGQQFAQMEVKVVMAKLLQ 456 LG C+G A+ E ++ + LL Sbjct: 358 GLGIHYCLGATLARAEAEIGLRALLD 383 >1UE8-A nrPDB Length = 367 Score = 162 bits (409), Expect = 3e-40, Method: Composition-based stats. Identities = 67/410 (16%), Positives = 136/410 (33%), Gaps = 77/410 (18%) Query: 60 LQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMS--------TKYNKDSKMYRA 111 + D F K+ PV + + E K L T YN +M R+ Sbjct: 1 MYDWFKQMRKE-SPVY----YDGKVWNLFKYEDCKMVLNDHKRFSSNLTGYNDKLEMLRS 55 Query: 112 LQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAK 171 + F + + + + R + AF+ S+L ++ E +L+ L+ + Sbjct: 56 GKVFFDIPT--RYTMLTSDPPLHDELRNLTADAFNPSNLP--VDFVREVTVKLLSELDEE 111 Query: 172 ADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAK 231 + + ++ G+ P + VK + + Sbjct: 112 ------FDVIESFAIPLPILVISKMLGI---------NPDVKKVKDWSDLVAL------- 149 Query: 232 FLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDEG 291 +L E R+ ++E R + D+ +I + + EG Sbjct: 150 -------RLGRADEIFSIGRKYLELISFSKKELDSRKGKEIVDLTGKIANSNLSELEKEG 202 Query: 292 LLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQ 351 F+ IAG+ET+ N + +++ + + G L+ Sbjct: 203 Y---FILLMIAGNETTTNLIGNA-----------------IEDFTLYNSWDYVREKGALK 242 Query: 352 YLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTF 411 ++E+LR PP T R+ +E+ I + + R + F+DP +F Sbjct: 243 ----AVEEALRFSPPVMRTIRVTKEKVKIRDQVIDEGELVRVWIASANRDEEVFKDPDSF 298 Query: 412 NPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFR 461 PDR + F G C+G A++E ++ + + ++ + Sbjct: 299 IPDR-------TPNPHLSFGSGIHLCLGAPLARLEARIALEEFAKKFRVK 341 >3TKT-A nrPDB Length = 450 Score = 161 bits (408), Expect = 5e-40, Method: Composition-based stats. Identities = 66/396 (16%), Positives = 142/396 (35%), Gaps = 49/396 (12%) Query: 82 KTSVIVTSPESV-------KKFLMSTKYNKDSKMYRAL--QTVFGERLFGQGLVSECNYE 132 + +V+S + V FL + K + + + + G + + + Sbjct: 71 EPFWLVSSFDGVMKASKDNATFLNNPKSTVFTLRVGEMMAKAITGGSPHLVESLVQMDAP 130 Query: 133 RWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDIL 192 + K RR+ F +L L + A + ++ + G+ M + + ++ Sbjct: 131 KHPKLRRLTQDWFMPKNLARLDGEIRKIANEAIDRM--LGAGEEGDFMALVAAPYPLHVV 188 Query: 193 AKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQ 252 + G+ Q E + +++ L P + Q+ V ++ + Sbjct: 189 MQIL-GVPPEDEPKMLFLTQQMFGGQDEDM--NKSGLKDLPPEQISQI--VAGAVAEFER 243 Query: 253 VGRDWVQRRREALKRGEEVPADILTQILKA--EEGAQDDEGLLDNFVTFFIAGHETSANH 310 RR D+ T I A + D ++ AGH+T++ Sbjct: 244 YFAGLAAERR------RNPTDDVATVIANAVVDGEPMSDRDTAGYYIITASAGHDTTSAS 297 Query: 311 LAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGT 370 A + L+R P++ AR++A+ + L +++E++R P Sbjct: 298 SAGAALALARDPDLFARVKADRN------------------LLPGIVEEAIRWTTPVQHF 339 Query: 371 FRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPF 430 R +T + G ++ L+ + F +P F+P R P + F Sbjct: 340 MRTAATDTELCGQKIAAGDWLMLNYVAANHDPAQFPEPRKFDPTR-------PANRHLAF 392 Query: 431 SLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQ 466 G C+G A++E++V++ LL R++ + G+ Sbjct: 393 GAGSHQCLGLHLARLEMRVLLDVLLDRVDSLELAGE 428 >5H1Z-A nrPDB Length = 407 Score = 161 bits (407), Expect = 7e-40, Method: Composition-based stats. Identities = 49/334 (14%), Positives = 119/334 (35%), Gaps = 48/334 (14%) Query: 125 LVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDML 184 + + + QRR + AF+ S +V + + + ++++ LE TP D + Sbjct: 90 MFIAMDRPKHTGQRRTVAPAFTPSEMVRMSDNIRMRTAEVLDSLEW----NTPFDWVDTV 145 Query: 185 TYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVR 244 + + F + + + + + + +L +R Sbjct: 146 SVELTTQMLAILFDFPWEER--------RKLTFWSDWAGDI-----ELVKNEELRLERLR 192 Query: 245 ESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDE-GLLDNFVTFFIAG 303 W K G+ D+++ ++ ++ A+ D+ L N + + G Sbjct: 193 HMYECGGYFQNLW------NAKIGKPPTPDLISMMIHSDAMAEMDQMEFLGNLILLIVGG 246 Query: 304 HETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRL 363 ++T+ N ++ L P+ A+L+A+ + ++E +R Sbjct: 247 NDTTRNTMSAVAYGLDLFPDQRAKLEADP------------------SMIPNTVQEIIRW 288 Query: 364 YPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKP 423 P R ++ ++G ++ L R ++ FE+ DR Sbjct: 289 QTPLAHMRRTATVDSELEGQQIKAGDKLALWYISANRDESVFENADRIIVDR------PN 342 Query: 424 RFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQR 457 + F G C+G + A++++ V++ ++ +R Sbjct: 343 ARRHLAFGHGIHRCVGARLAELQIAVLLEEMAKR 376 >5HIW-A nrPDB Length = 398 Score = 161 bits (406), Expect = 8e-40, Method: Composition-based stats. Identities = 73/406 (17%), Positives = 130/406 (32%), Gaps = 52/406 (12%) Query: 84 SVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDL 143 SV V L + T + +G + E + RR+ + Sbjct: 30 SVYFDEGLGVPVVLRGADVVAVLRDSETFSTRTYDTGIMKGALVTLGGEAHTRMRRLFNA 89 Query: 144 AFSRSSLVSLMET-FNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETS 202 S + E A ++VE L K + + D + + A FG+ Sbjct: 90 VLSPRVISRYEEATVTPVARRVVERLVRKERAE----LFDDFAISMPMGVTSALFGLPEE 145 Query: 203 MLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRR 262 + + + ++ ++ +P + E R + + R+ +R Sbjct: 146 RIAENDALIRKMIRSVV-------------MPQDPVVVAEGRSAHAAMEAQLREIAEREV 192 Query: 263 EALKRGEEVPADILTQILKAEEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQP 322 + + +I I+ G E +T + +ET++ LA ++ L P Sbjct: 193 AH--PSDTLLGEIARAIVAEGLGGV--EACEGVVLTLILGSYETTSWMLANLLVALLAHP 248 Query: 323 EIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDG 382 + + +L+ + L Q ++ES R A G R +E E I G Sbjct: 249 DAMNQLRQQP------------------SLLPQAIEESTRWCSSAAGIVRFVEREATIGG 290 Query: 383 VRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQF 442 + T L S + + P TF+ R G F G C+G Sbjct: 291 ETLAAGTILYLSLIARHYDEEIYPRPETFDIHRRPVG-------MLNFGGGLHYCVGAPL 343 Query: 443 AQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPVLCTLRP 488 A+ME +V ++ LL+R P R Q T P Sbjct: 344 ARMEARVGVSLLLERF-----PALRADPTVQPTFSTAPRGAAAFGP 384 >2UUQ-A nrPDB Length = 414 Score = 159 bits (403), Expect = 2e-39, Method: Composition-based stats. Identities = 58/368 (15%), Positives = 116/368 (31%), Gaps = 56/368 (15%) Query: 126 VSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLT 185 + + + R+++ F+ + ++ T + + +E L A G + L Sbjct: 96 MVMQDPPVHTEFRKLVSRGFTPRQVETVEPTVRKFVVERLEKLRANGGG----DIVTELF 151 Query: 186 YTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRE 245 ++ G+ P + +G T + L + Sbjct: 152 KPLPSMVVAHYLGV----------PEEDWTQ--FDGWTQAIVAANAVDGATTGAL----D 195 Query: 246 SIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDEG----LLDNFVTFFI 301 ++ + ++RRR E D ++ ++ A GA D +L T Sbjct: 196 AVGSMMAYFTGLIERRR------TEPADDAISHLVAAGVGADGDTAGTLSILAFTFTMVT 249 Query: 302 AGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESL 361 G++T L ++ L R+P+ L + + + ++E L Sbjct: 250 GGNDTVTGMLGGSMPLLHRRPDQRRLLLDDPEG------------------IPDAVEELL 291 Query: 362 RLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYF-EDPLTFNPDRFGPGA 420 RL P G R + I +P +L R + + D + R Sbjct: 292 RLTSPVQGLARTTTRDVTIGDTTIPAGRRVLLLYGSANRDERQYGPDAAELDVTRCPRNI 351 Query: 421 PKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLD 480 FS G C+G A+M+ +V + +LL R V R + ++ Sbjct: 352 -------LTFSHGAHHCLGAAAARMQCRVALTELLARCPDFEVAESRIVWSGGSYVRRPL 404 Query: 481 PVLCTLRP 488 V + Sbjct: 405 SVPFRVTS 412 >2X9P-A nrPDB Length = 404 Score = 158 bits (399), Expect = 5e-39, Method: Composition-based stats. Identities = 69/414 (16%), Positives = 135/414 (32%), Gaps = 66/414 (15%) Query: 63 VFLDWAKKYGPVVRVNVF-HKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLF 121 L + GP+ RV + +VT +K+ L + + + F Sbjct: 30 PLLRALQDRGPIHRVRTPAGDEAWLVTRHAELKQLLHDERI-GRTHPDPPSAAQYVRSPF 88 Query: 122 GQGLVSECNYE----RWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTP 177 L+S+ + E + + RR++ FS ++ + E A+ L++ P Sbjct: 89 LDLLISDADAESGRRQHAETRRLLTPLFSARRVLEMQPKVEEAADTLLDAF---IAQGPP 145 Query: 178 VSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKR 237 + LT + G+ + +L GI + Sbjct: 146 GDLHGELTVPFALTVLCEVIGVPPQRR--------AELTTLLAGIAKLDDR--------- 188 Query: 238 KQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDEGLLDNFV 297 + L V+ +R E DI++++ +G ++ + + Sbjct: 189 ---EGAVRAQDDLFGYVAGLVEHKRA------EPGPDIISRL---NDGELTEDRVAHLAM 236 Query: 298 TFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVL 357 AG ++ A+ + V+ L+ P+ A A+ D +++ + Sbjct: 237 GLLFAGLDSVASIMDNGVVLLAAHPDQRAAALADPD------------------VMARAV 278 Query: 358 KESLR--LYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDR 415 +E LR + R E+ GV + +LF + + F P F+ R Sbjct: 279 EEVLRTARAGGSVLPPRYASEDMEFGGVTIRAGDLVLFDLGLPNFDERAFTGPEEFDAAR 338 Query: 416 FGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFG 469 + F G CIG A++E++ + KL RL L P Sbjct: 339 -------TPNPHLTFGHGIWHCIGAPLARLELRTMFTKLFTRLP-ELRPELPVE 384 >4PWV-A nrPDB Length = 446 Score = 157 bits (397), Expect = 8e-39, Method: Composition-based stats. Identities = 55/407 (13%), Positives = 124/407 (30%), Gaps = 54/407 (13%) Query: 85 VIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLA 144 +V+ V K K + + G +++ + R V+ + Sbjct: 77 WVVSRYADVMALYKDNKKLTSEKGNVLVTLLAGGDSAAGKMLAVTDGAMHRGLRNVLLKS 136 Query: 145 FSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSML 204 FS +L +++ +LV + + + + + + S L Sbjct: 137 FSPQALKPIVDQIRVNTTRLVVDAARRGECDFAADVAEQIPLNTI------------SDL 184 Query: 205 LGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREA 264 LG + + + + +S + + + + + + V RR Sbjct: 185 LGVPAADREFLLKLNKSALSSED--------ADQSATDAWLARNEILLYFSELVAERRA- 235 Query: 265 LKRGEEVPADILTQILKAEEGAQ--DDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQP 322 + D+++ + + + +E ++ N + + G ETS + +V ++ P Sbjct: 236 -----KPTEDVISVLANSMVDGKPLTEEVIVLNCYSLILGGDETSRLSMIDSVQTFTQYP 290 Query: 323 EIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDG 382 + L+ L +E LR PA R + + G Sbjct: 291 DQWELLRDGKVT------------------LESATEEVLRWATPAMHFGRRAVTDMELHG 332 Query: 383 VRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQF 442 + + R + F DP F+ +R + F G C+G Sbjct: 333 QVIAAGDVVTLWNNSANRDEEVFADPYAFDLNRSPNK-------HITFGYGPHFCLGAYL 385 Query: 443 AQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPVLCTLRPR 489 + EV ++ L + G+ + L L + ++P Sbjct: 386 GRAEVHALLDALRTYTTGFEITGEPQRI-HSNFLTGLSRLPVRIQPN 431 >3BUJ-A nrPDB Length = 397 Score = 156 bits (394), Expect = 2e-38, Method: Composition-based stats. Identities = 72/419 (17%), Positives = 137/419 (32%), Gaps = 54/419 (12%) Query: 77 VNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQ---GLVSECNYER 133 V+ V+ V+ L ++ + + R + G L + ++ + Sbjct: 28 VHRGAHRVWYVSRFADVRAVLGDERFA-RTGIRRFWTDLVGPGLLAEIVGDIILFQDEPD 86 Query: 134 WHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILA 193 + R V+ AFS S+L L + L+ A + + + D L Y Sbjct: 87 HGRLRGVVGPAFSPSALRRLEPVIAGTVDDLL----RPALARGAMDVVDELAYPLALRAV 142 Query: 194 KAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQV 253 G+ + + + + G + +R +I Sbjct: 143 LGLLGLPAADWGAVGRWSRDVGRTLDRG-------------ASAEDMRRGHAAIAEFADY 189 Query: 254 GRDWVQRRREALKRGEEVPADILTQILKAEE-GAQDDEGLLDNFVTFFIAGHETSANHLA 312 +R E D+L +L A + G ++ VTF GHET A+ + Sbjct: 190 VERA------LARRRREGGEDLLALMLDAHDRGLMSRNEIVSTVVTFIFTGHETVASQVG 243 Query: 313 FTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFR 372 V+ L P+ + L+ D L+Q ++E LR P R Sbjct: 244 NAVLSLLAHPDQLDLLRRRPD------------------LLAQAVEECLRYDPSVQSNTR 285 Query: 373 LLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSL 432 L+ + + G R+ + ++ R ++ P F+ +R + F Sbjct: 286 QLDVDVELRGRRLRRDDVVVVLAGAANRDPRRYDRPDDFDIERDPVPS-------MSFGA 338 Query: 433 GHRSCIGQQFAQMEVKVVMAKLLQRLEFRL-VPGQRFGLQEQATLKPLDPVLCTLRPRG 490 G R C+G A+ +++ +A L + RL Q + + L + P G Sbjct: 339 GMRYCLGSYLARTQLRAAVAALARLPGLRLGCASDALAYQPRTMFRGLASLPIAFTPGG 397 >3IVY-A nrPDB Length = 433 Score = 156 bits (394), Expect = 2e-38, Method: Composition-based stats. Identities = 49/338 (14%), Positives = 105/338 (31%), Gaps = 56/338 (16%) Query: 125 LVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDML 184 ++ + + R++I F+ ++ L + E+A+++ A G + + Sbjct: 115 VMLNMDAPHHTRLRKIISRGFTPRAVGRLHDELQERAQKIAAEAAAAGSG----DFVEQV 170 Query: 185 TYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVR 244 + G+ ++ + + Sbjct: 171 SCELPLQAIAGLLGVPQEDRGKLFHWSNEMTGNED----------------PEYAHIDPK 214 Query: 245 ESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGA--QDDEGLLDNFVTFFIA 302 S L + A ++ + DI+TQ+++A+ D+ V +A Sbjct: 215 ASSAELIGYA------MKMAEEKAKNPADDIVTQLIQADIDGEKLSDDEFGFFVVMLAVA 268 Query: 303 GHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLR 362 G+ET+ N + +M + P+ L + E +R Sbjct: 269 GNETTRNSITQGMMAFAEHPDQWE--------------------LYKKVRPETAADEIVR 308 Query: 363 LYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPK 422 P R + + GV++ ++ + F+DP TFN R P Sbjct: 309 WATPVTAFQRTALRDYELSGVQIKKGQRVVMFYRSANFDEEVFQDPFTFNILR----NPN 364 Query: 423 PRFTYFPFSL-GHRSCIGQQFAQMEVKVVMAKLLQRLE 459 P + F G CIG A+M + ++ + + Sbjct: 365 P---HVGFGGTGAHYCIGANLARMTINLIFNAVADHMP 399 >3OFT-A nrPDB Length = 396 Score = 149 bits (377), Expect = 2e-36, Method: Composition-based stats. Identities = 63/423 (14%), Positives = 124/423 (29%), Gaps = 69/423 (16%) Query: 72 GPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNY 131 G V I + V++ + + + L G Q + + + Sbjct: 38 GLVWSTANGGH--WIAARGDVVREL----WGDAERLSSQCLAVTPGLGKVMQFIPLQQDG 91 Query: 132 ERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDI 191 R + + +V+L A +L+E L + ++L Sbjct: 92 AEHKAFRTPVMKGLASRFVVALEPKVQAVARKLMESLRPRGSCDFVSDFAEILPLN---- 147 Query: 192 LAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLR 251 + + ++ Q + P + +++++ Sbjct: 148 IFLTLIDVPLEDRPRLRQLGVQLTR-----------------PDGSMTVEQLKQAAD--- 187 Query: 252 QVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQ--DDEGLLDNFVTFFIAGHETSAN 309 ++++R + D+ ++IL G + + G +T A Sbjct: 188 DYLWPFIEKRMA------QPGDDLFSRILSEPVGGRPWTVDEARRMCRNLLFGGLDTVAA 241 Query: 310 HLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWG 369 + + L+R PE L+ D + E +R YP Sbjct: 242 MIGMVALHLARHPEDQRLLRERPD------------------LIPAAADELMRRYPTV-A 282 Query: 370 TFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFP 429 R + DGV + + + + FE P DR + Sbjct: 283 VSRNAVADVDADGVTIRKGDLVYLPSVLHNLDPASFEAPEEVRFDR-----GLAPIRHTT 337 Query: 430 FSLGHRSCIGQQFAQMEVKVVMAKLLQRL-EFRLVPGQRFGLQEQATLKPLDPVLCTLRP 488 +G C+G A+MEV V + + L + EF L P + T+K + CT P Sbjct: 338 MGVGAHRCVGAGLARMEVIVFLREWLGGMPEFALAPDKAV------TMKGGNVGACTALP 391 Query: 489 RGW 491 W Sbjct: 392 LVW 394 >5HH3-A nrPDB Length = 397 Score = 149 bits (375), Expect = 3e-36, Method: Composition-based stats. Identities = 51/399 (12%), Positives = 112/399 (28%), Gaps = 63/399 (15%) Query: 80 FHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRR 139 +T+ + T + +++ L S ++ +Y G +++ + + RR Sbjct: 50 GGRTAWLATGYDEIRQVLSSDDFS-ARLLYGGTAAGITWP----GFLTQYDPPEHTRLRR 104 Query: 140 VIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGM 199 ++ AF+ + + ++ +EA PV ++ G+ Sbjct: 105 MVAPAFAVRRMQKFQPQVERVVQDSLDAIEALG---GPVDFVPRFGWSVATTATCDFLGI 161 Query: 200 ETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQ 259 + L + + + ++ Sbjct: 162 PRDDQADLARSLHAS------------------------RTERSGKRRTAAGNKFMTYMN 197 Query: 260 RRREALKRGEEVPADILTQILKAEEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELS 319 + +R + D+ +++ D L AG + A LA ++ Sbjct: 198 KMTARTRR--DPGDDMFGVVVREYGDEITDAELTGVAAFVMGAGADQVARFLAAGAWLMA 255 Query: 320 RQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTF-RLLEEET 378 PE A L+ + D V L E +R T R+ ++ Sbjct: 256 DDPEQFALLREKPDTVPDW------------------LDEVIRYLTTDEKTHPRVATDDV 297 Query: 379 LIDGVRVPGNTPLLFSTYVMGRMDTYFEDP-LTFNPDRFGPGAPKPRFTYFPFSLGHRSC 437 I + + S R F P F+ R R + F G C Sbjct: 298 RIGDHLIKAGDTVTCSLLAANR--RNFPRPEDRFDITR-------VRPEHLAFGHGIHHC 348 Query: 438 IGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATL 476 +G+ A++ + + L R + ++ Sbjct: 349 LGRSLAELVFRTAIPALAHRFPTLRLAEPHREIRLGPPP 387 >6FYJ-A nrPDB Length = 421 Score = 148 bits (373), Expect = 6e-36, Method: Composition-based stats. Identities = 69/418 (16%), Positives = 134/418 (32%), Gaps = 46/418 (11%) Query: 73 PVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYE 132 + + K ++ + E+ + F + K+ K A + LFG+ V + + Sbjct: 39 DIFETRLLGKKAICMGGKEAAEIFYDTEKF----KRKDAAPNRVVQTLFGKNGVQALDGQ 94 Query: 133 RWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDIL 192 ++ + S L L + ++ E V+ K + V + + Sbjct: 95 THKHRKEMFMSIMSPDELEKLTDITKKQWEIAVD----KWEQMDKVILYEEAKEIMCRTA 150 Query: 193 AKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQ 252 + A G+ + + K + ++ K G+ + E + + Sbjct: 151 CQWA-GVPVQE-----NEVKRLTKNLGAMFESAAAVGLKHWLGRHARNYEEIWIEELIDR 204 Query: 253 VGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDEGLLDNFVTFFIAGHETSANHLA 312 V V D+ +L E A + +L V A + Sbjct: 205 VRDGKVNPPENTTLHKFSWYRDLEGNLLDTETAAVEVINILRPIVAI--------AIFIN 256 Query: 313 FTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFR 372 F + L PE +L++ G +Y ++E R YP Sbjct: 257 FIALALHHYPEEKEKLKS-----------------GDKKYSQMFVQEVRRFYPFFPFVVA 299 Query: 373 LLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSL 432 L++++ G + T L Y +++P F+PDRF P F++ P Sbjct: 300 LVKKDFTWKGYKFEEGTLTLLDLYGTNHDPEIWKNPDVFSPDRFAKWEGSP-FSFIPQGG 358 Query: 433 GH----RSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLK-PLDPVLCT 485 G C G+ +KV + L R+++ VP Q + P V+ Sbjct: 359 GDYFMGHRCAGEWVTIEVMKVSLDYLTNRMDYE-VPDQDLSFSMASMPSIPHSKVVIK 415 >3OO3-A nrPDB Length = 384 Score = 147 bits (371), Expect = 1e-35, Method: Composition-based stats. Identities = 71/410 (17%), Positives = 124/410 (30%), Gaps = 72/410 (17%) Query: 81 HKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRV 140 + +VT + V+ L + +R G++ + + RR Sbjct: 38 GRKQWLVTGHDEVRAILAD----HERFSSMRPVDDEADRALLPGILQAYDPPDHTRLRRT 93 Query: 141 IDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGME 200 + A+S + L E E E L+ PV + +A Sbjct: 94 VAPAYSARRMERLRPRIEEIVE---ECLDDFESVGAPVDFVRHAAWPIPAYIAC------ 144 Query: 201 TSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQR 260 LG + + M+ SR + L G + Sbjct: 145 --EFLGVPRDDQAELSRMIRESRESRLPRQRTLSGLGIVNYT-----------------K 185 Query: 261 RREALKRGEEVPADILTQILKAEEGAQ-DDEGLLDNFVTFFIAGHETSANHLAFTVMELS 319 R + KR + P D + ++ E GA+ DE L I E A LA V+ L Sbjct: 186 RLTSGKRRD--PGDGMIGVIVREHGAEISDEELAGLAEGNLIMAAEQMAAQLAVAVLLLV 243 Query: 320 RQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGT-FRLLEEET 378 P+ +A L+ + + + +E LR R+ + Sbjct: 244 THPDQMALLRE------------------KPELIDSATEEVLRHASIVEAPAPRVALADV 285 Query: 379 LIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCI 438 + G + L S R F+ R + T+ F G CI Sbjct: 286 RMAGRDIHAGDVLTCSMLATNRAPG-----DRFDITR-------EKATHMAFGHGIHHCI 333 Query: 439 GQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGL-QEQATLKPLDPVLCTLR 487 G A+++++V + ++ R P R + +E KP P + Sbjct: 334 GAPLARLQLRVALPAVVGRF-----PSLRLAVPEEDLRFKPGRPAPFAVE 378 >6BLD-A nrPDB Length = 419 Score = 147 bits (370), Expect = 1e-35, Method: Composition-based stats. Identities = 51/363 (14%), Positives = 117/363 (32%), Gaps = 47/363 (12%) Query: 126 VSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLT 185 + R K R+++ AF+ + + ++ A+ +V+ L + G ++ Sbjct: 102 FLAMDPPRHTKLRKLVSAAFTPRQVRRIEDSIKINAKGIVDEL--RMAGGGVDFVEHCAK 159 Query: 186 YTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRE 245 + L+ + ++ ++ A ++ R+ L + E Sbjct: 160 ELPIRTLSDMV-----GIPEADRERVAHAADALVSWADPRYLN-------GREPLAVLFE 207 Query: 246 SIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGA--QDDEGLLDNFVTFFIAG 303 + +L QV RR + D+ + ++ AE D + FV +AG Sbjct: 208 NQMYLHQVAASLAAERR------DRPGDDLFSALVNAEVDGDRLADADVAAFFVLLAVAG 261 Query: 304 HETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRL 363 ++T+ ++ + L+ P A L A+ D IG ++E +R Sbjct: 262 NDTTRQTISHGLKALTDFPSQKAWLLADFDTRIG-----------------TAVEELVRW 304 Query: 364 YPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKP 423 P R + + G + ++ + F P + R Sbjct: 305 ATPVMTFRRTAAADFELGGQLIRAGEKVVMFYASGNWDEDAFCHPERLDLSRSPNPHVGF 364 Query: 424 RFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPVL 483 C+G A+ +++ + +LL ++ + + + + Sbjct: 365 GGGGVH------FCLGAHLARAQLRAIFGELL--VQLPDIQAGDPVYVPGNFVHAIRSMP 416 Query: 484 CTL 486 CT Sbjct: 417 CTF 419 >5D3U-A nrPDB Length = 427 Score = 146 bits (367), Expect = 3e-35, Method: Composition-based stats. Identities = 80/439 (18%), Positives = 139/439 (31%), Gaps = 65/439 (14%) Query: 63 VFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDS--------KMYRALQT 114 V+ D A++ PV V + + V + L + D + L Sbjct: 40 VYADLAQRR-PVHWVERLN--AWAVLTYADCAAGLKDPRLTADRGTEVLAAKFPGQPLPP 96 Query: 115 VFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADG 174 + + +V + RR + F+R++ + + A LV + A G Sbjct: 97 DNIFHRWTKNVVMYTDPPLHDALRRSVRAGFTRAAHQHYDQVLQKVAHDLVASIPA---G 153 Query: 175 QTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLP 234 T + L A AFG+ L NT+ + Sbjct: 154 ATEIDAVPALAAELPVRSAVHAFGVPEEDLGFL---------------IPRVNTIMTYFS 198 Query: 235 GKRKQL---REVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEG--AQDD 289 G + Q + E + L + +Q R G+ +P ++ ++ A++G Sbjct: 199 GPKDQPVTQEIILEKLTDLHTYASELLQGMR-----GKVLPDTVIARLAAAQDGLTETTP 253 Query: 290 EGLLDNFVTFFIAGHE-TSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLG 348 E + FIA T+ L+ + +R P V R A+ V Sbjct: 254 EQTVHQLALVFIALFAPTTPGSLSSGTLAFARNPRQVERFLADQACV------------- 300 Query: 349 RLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDP 408 E LR T+R+ ++ + GVR+ L R FE P Sbjct: 301 -----DNTANEVLRYNASNQFTWRVAAKDVEMGGVRIEAGQTLALFLGSANRDANMFERP 355 Query: 409 LTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRF 468 F+ DR + F G +C+ Q +++K LL R G+ Sbjct: 356 NDFDLDR------PNSARHLSFGQGVHACLAAQLISLQLKWFYVALLNRFPGIRTAGEPI 409 Query: 469 GLQEQATLKPLDPVLCTLR 487 E + L + +LR Sbjct: 410 -WNENLEFRSLRSLPLSLR 427 >6G5O-A nrPDB Length = 399 Score = 145 bits (366), Expect = 4e-35, Method: Composition-based stats. Identities = 67/433 (15%), Positives = 138/433 (31%), Gaps = 64/433 (14%) Query: 68 AKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTK-YNKDSKMYRALQTVFGERLFGQGLV 126 +K YG +N ++ + V+K + K + + R + + + + Sbjct: 16 SKGYGE---MNDQDDPVTMLLRHKDVRKSAHNYKTFQSGAVPGRIVIPSEVDIRDTRQIP 72 Query: 127 SECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTY 186 E + R +++ F R E + ++VE K + Sbjct: 73 FEVDPPVHGVYRAIVEPWFKRPLQAEYQEKLTAQISEIVEETLLKGSVEVVTD------- 125 Query: 187 TAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRES 246 A+ + ++A L P S++ + + T + + L G + Sbjct: 126 FALRLQSRAL-------TLLLNTPFSES-ETWISWGTHVFRSEGEALDG---------DK 168 Query: 247 IRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQ--DDEGLLDNFVTFFIAGH 304 L + + R E D+ + +L +E + E + V F G Sbjct: 169 ANILYHYIDEQIDRA------SENPGDDMYSVLLNSEFEGRKLTKEEVKGVMVLTFAGGR 222 Query: 305 ETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLY 364 +T N + ++ L+ PE + RL+ E + + ++E +R + Sbjct: 223 DTVINAVTNSIAYLAEHPEALERLRKEPE------------------ITGRAVEEMIRYF 264 Query: 365 PPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPR 424 P R++ E+T + V ++ + R FE+P DR Sbjct: 265 SPLTQMGRVVTEDTHVCEHAVKADSRISLCWASANRDAAVFENPNEIVLDR-------KV 317 Query: 425 FTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQR---LEFRLVPGQRFGLQEQATLKPLDP 481 + F H +C+G A+ +K+++ L Q+ E L Sbjct: 318 NPHVGFGFSHHNCLGATHARQILKILLQTLAQKVASFEILDYKENIEDLDHFQRKVGFHN 377 Query: 482 VLCTLRPRGWQPA 494 + P A Sbjct: 378 IQIKFNPLTKLAA 390 >6HQD-A nrPDB Length = 420 Score = 145 bits (365), Expect = 6e-35, Method: Composition-based stats. Identities = 52/409 (12%), Positives = 131/409 (32%), Gaps = 53/409 (12%) Query: 68 AKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVS 127 A +YGP + F I T+ + + S+ + S + + Sbjct: 52 ASEYGPYWSITKFSDIVAIDTNHK-----VFSSDHTNGSFVLDDTTLNAVDGGIYLPNFL 106 Query: 128 ECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYT 187 + + R V+ + +L+ T E+ ++++ L + D ++ Sbjct: 107 GMDPPKHDVHRMVVSPIVAPQNLLRFEATIRERTKRVLSELPI----GEEFNWVDRVSIE 162 Query: 188 AMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESI 247 ++ + G+ S ++ E+ E + Sbjct: 163 LTTMMLATLLDFPFDDRRKLTRWSDIITTRPGYGLVDSW----------EQRESELMECL 212 Query: 248 RFLRQVGRDWVQRRREALKRGEEVPADILTQILKA-EEGAQDDEGLLDNFVTFFIAGHET 306 + +++ + R+A+ D+++ + + E L + G++T Sbjct: 213 AYFQRLYAE-----RQAMPPKP----DLISMLAHSPEMQDLTPTDFLGTLALLIVGGNDT 263 Query: 307 SANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPP 366 + + ++ + M P+ +++ L+ V+ E +R P Sbjct: 264 TRSSMSGSAMACHLYPQEFDKVRNNRA------------------LLASVIPEVVRWQTP 305 Query: 367 AWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFT 426 R E+ G ++ ++ R D + P+ F DR Sbjct: 306 IAHMRRTALEDVEFRGKQIRKGDKVVMWYLSGNRDDEVIDRPMDFIADR------PRARH 359 Query: 427 YFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQAT 475 + F G C+G + A++++K++ ++ +R V G+ + Sbjct: 360 HLSFGFGIHRCLGNRLAELQLKILWEEMCERYSRIEVCGEPVRVPSNLV 408 >2WIY-A nrPDB Length = 394 Score = 144 bits (363), Expect = 8e-35, Method: Composition-based stats. Identities = 66/399 (16%), Positives = 116/399 (29%), Gaps = 61/399 (15%) Query: 84 SVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDL 143 + +V+ V F + + G + RR + Sbjct: 42 TYLVSRYADVSHFAKLPIMSVEPG-----WADAGPWAVASDTALGSDPPHHTVLRRQTNK 96 Query: 144 AFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSM 203 F+ + + T E L++ +EA + + L + + Sbjct: 97 WFTPKLVDGWVRTTRELVGDLLDGVEA----GQVIEARRDLAVVPTHVTMARVLQLPEDD 152 Query: 204 LLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRRE 263 + + +A+ + + R E Sbjct: 153 ADAVMEAMFEAM--------------------LMQSAEPADGDVDRAAVAFGYLSARVAE 192 Query: 264 ALKRGEEVPADILTQIL--KAEEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQ 321 L+ P D L L A G + + + F+ GH +A + +R+ Sbjct: 193 MLEDKRVNPGDGLADSLLDAARAGEITESEAIATILVFYAVGHMAIGYLIASGIELFARR 252 Query: 322 PEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLID 381 PE+ + + ++ E +R+ PP R E+ I Sbjct: 253 PEVFTAFRNDESARA------------------AIINEMVRMDPPQLSFLRFPTEDVEIG 294 Query: 382 GVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQ 441 GV + +P+ F R F+DP F+ R P F LG SC GQ Sbjct: 295 GVLIEAGSPIRFMIGAANRDPEVFDDPDVFDHTR-----PPAASRNLSFGLGPHSCAGQI 349 Query: 442 FAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLD 480 ++ E V A L +R E R L E+ T+ D Sbjct: 350 ISRAEATTVFAVLAERYE-------RIELAEEPTVAHND 381 >3WEC-A nrPDB Length = 419 Score = 144 bits (362), Expect = 1e-34, Method: Composition-based stats. Identities = 66/450 (14%), Positives = 132/450 (29%), Gaps = 71/450 (15%) Query: 51 KKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSK--- 107 D V+ + P+ R + + IV S K L S + KD Sbjct: 17 PFDPTFKADPYPVYARLRTEL-PIHRSALG---AWIVADYTSCDKVLRSRLFGKDFANST 72 Query: 108 --------MYRALQTVFGERLFGQGLVSEC-NYERWHKQRRVIDLAFSRSSLVSLMETFN 158 M + G + G + + R ++ AF+RS+ S+ + Sbjct: 73 FFDHLTSMMGEDMPPFLGLGIDGDARPFMLTDPPEHTRLRGLVSDAFTRSTTTSMDDIVL 132 Query: 159 EKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLM 218 A V LE D + V + + + G+ Sbjct: 133 SAASSAVRHLEHCTDAVSEV--AEPFPVEVLSSI----LGIPDKDRGR-----------F 175 Query: 219 LEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQ 278 E L ++ +I R L P ++ + Sbjct: 176 SEWSNLVAGVLDINFAIPKEVADRRSAAIEESIDYFRT--------LATSGNAPEGLVRR 227 Query: 279 ILKAEEGA--QDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVI 336 + + G + + + +AG ET++N + ++ SR + +++A Sbjct: 228 LSEVSHGGDQLSVDEIAATCLLITVAGQETTSNTIGNMLITFSRHADQFEQVRANPQ--- 284 Query: 337 GSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTY 396 ++ + E LR PPA R+ E+ + G + ++ Sbjct: 285 ---------------FIENAVAEVLRFEPPAHEAGRIALEDCEVSGANITKGDAVMVLLA 329 Query: 397 VMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQ 456 R E TF+ R P + + G C+G A ++ + +L Q Sbjct: 330 SGNR--EAVERGDTFSVTR-------PDVSSLSYGRGIHHCLGSALANSMLQHFLRELSQ 380 Query: 457 RLEFRLVPGQRFGLQEQATLKPLDPVLCTL 486 R + + + L+ + + + Sbjct: 381 RYR-SIEVAEPINYKPGMGLRGPETLSVAV 409 >5KYO-A nrPDB Length = 430 Score = 143 bits (361), Expect = 1e-34, Method: Composition-based stats. Identities = 56/364 (15%), Positives = 121/364 (33%), Gaps = 65/364 (17%) Query: 128 ECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYT 187 + R +++ L + + + A L+E K + L Sbjct: 124 SLDPPEHRPFRSLLNENLGPKPLRPIEQVVTDLAVSLIEGFRPKGRCNFTHEFAEQLPVR 183 Query: 188 AMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESI 247 ++ +K + + T ++ + + Sbjct: 184 I------------FMRIVDLPVEDLPKLKHLADQYTRPDGSIP------------LDDVT 219 Query: 248 RFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQ--DDEGLLDNFVTFFIAGHE 305 + R+ R ++ RR + D++++++ E G + D + + + G + Sbjct: 220 KQFREYLRPVIEARRI------KPGEDMISRMINGEVGGRPLTDIEAENICIQVLVGGLD 273 Query: 306 TSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYP 365 T N L FT L++ + + A+ + L E R +P Sbjct: 274 TVVNMLGFTFSHLAKDHALRRAIAADP------------------SLIDDALLEFFRRFP 315 Query: 366 PAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRF 425 R + + +GV + ++ T V+ D EDPL F R Sbjct: 316 VVSSA-REVLRDQEFEGVLLKAGDMVMAPTVVVAMDDARNEDPLEFRLGR-------KAR 367 Query: 426 TYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPVLCT 485 + F G +C G A+ME+KVV+ + R+ F +++ A L+ + ++ + Sbjct: 368 QHSTFGKGSHTCPGAHLARMEMKVVLREWFARIP-------EFRIEDDAPLRYSNGIVGS 420 Query: 486 LRPR 489 ++P Sbjct: 421 VKPF 424 >5EX8-A nrPDB Length = 424 Score = 137 bits (345), Expect = 9e-33, Method: Composition-based stats. Identities = 61/398 (15%), Positives = 120/398 (30%), Gaps = 63/398 (15%) Query: 81 HKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRV 140 +T+ + T + V++ L S K++ +Y G +++ + + RR+ Sbjct: 78 GRTAWLATGIDEVRQVLGSDKFS-ARLLYGGTAAGITWP----GFLTQYDPPEHTRLRRM 132 Query: 141 IDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGME 200 + AFS + + + ++ +E+ PV + G+ Sbjct: 133 VVPAFSHRRMQKFRPRVEQIVQDSLDTIESLG---GPVDFVPHFGWAIATPATCDFLGIP 189 Query: 201 TSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQR 260 + LA+ L R + R + G ++ Sbjct: 190 RDD----------------------QADLARILLASRTDRSDKRRTAA-----GNKFMTY 222 Query: 261 RREALKRGEEVPADILTQILKAEEG-AQDDEGLLDNFVTFFIAGHETSANHLAFTVMELS 319 ++ + + D L I+ E G A D L A + A LA + Sbjct: 223 MKQHVAQSRRGSGDDLFGIVGRENGDAITDAELTGVAAFVMGAAADQVARLLAAGAWLMV 282 Query: 320 RQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTF-RLLEEET 378 QP A L+ + + V + L E++R T R+ ++ Sbjct: 283 EQPAQFALLREKPETV------------------PEWLDETMRYLTTDEKTHPRVATQDV 324 Query: 379 LIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCI 438 I V + S R Y F+ R + + F G C+ Sbjct: 325 RIGNQLVKAGDTVTCSLLAANR-PNYPSAEDEFDITR-------EKAEHLAFGHGIHHCL 376 Query: 439 GQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATL 476 G+ A++ KV + L R + + + Sbjct: 377 GRAMAELMFKVSIPALAHRFPTLRLADPQREITLGPPP 414 >5OMS-A nrPDB Length = 409 Score = 133 bits (335), Expect = 1e-31, Method: Composition-based stats. Identities = 58/395 (14%), Positives = 124/395 (31%), Gaps = 55/395 (13%) Query: 101 KYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVS-LMETFNE 159 + S + A+ T G R FG + N + R +++ A + + + + Sbjct: 57 REVATSPDFEAVITPAGGRTFGHPAIIGVNGDIHADLRSMVEPALQPAEVDRWIDDLVRP 116 Query: 160 KAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLML 219 A + +E E + L + ++ + G + L + + Sbjct: 117 IARRYLERFENDGHAE--------LVAQYCEPVSVRSLGDLLGLQEVDSDKLREWFAKLN 168 Query: 220 EGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQI 279 T + E ++ +R V + + E ++ Sbjct: 169 RSFTNAAVDENGEFANPEGFA-EGDQAKAEIRAVVDPLIDKWIEHPDDSA------ISHW 221 Query: 280 LKAE---EGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVI 336 L +D E + + + + + +A T++ L +PE + + + Sbjct: 222 LHDGMPPGQTRDREYIYPTIYVYLLGAMQEPGHGMASTLVGLFSRPEQLEEVVDDP---- 277 Query: 337 GSKRYLDFEDLGRLQYLSQVLKESLRLYPPAW-GTFRLLEEETLIDGVRVPGNTPLLFST 395 + + + E LR P W T R+ + I GV +P TP++ S Sbjct: 278 --------------TLIPRAIAEGLRWTSPIWSATARISTKPVTIAGVDLPAGTPVMLSY 323 Query: 396 YVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLL 455 +E P ++ R P + F G+ +C G FA +++ + +L Sbjct: 324 GSANHDTGKYEAPSQYDLHR-------PPLPHLAFGAGNHACAGIYFANHVMRIALEEL- 375 Query: 456 QRLEFRLVPGQRFGLQEQAT-----LKPLDPVLCT 485 F +P +E + + T Sbjct: 376 ----FEAIPNLERDTREGVEFWGWGFRGPTSLHVT 406 >6G71-A nrPDB Length = 405 Score = 131 bits (329), Expect = 7e-31, Method: Composition-based stats. Identities = 58/398 (14%), Positives = 119/398 (29%), Gaps = 57/398 (14%) Query: 73 PVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYE 132 PV V + ++TS V + ++ + G + + + Sbjct: 35 PVAWVPEAGR--YLITSYSGVLAADVDQTTFSANEKKSLMLRAMGHSMLRK------DDP 86 Query: 133 RWHKQRRVIDLAFSRSSLVSLME-TFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDI 191 +RR + ++ + + F E A++ ++ G M Sbjct: 87 DHQVERRAWQPSLKPGTVKKVWKQKFAENADRYLDAYIDAGSGSD-----------FMQG 135 Query: 192 LAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLR 251 A L+G + ++ + + P + ++S + Sbjct: 136 FAAPFVAENLRALIGFENASEADLQRWSQTLIDGAGN----YPDDPDVWAKAKQSSDEID 191 Query: 252 QVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDEGLLDNFVTFFIAGHETSANHL 311 + +Q +L+ +L++ + E + N G + L Sbjct: 192 AALEEMIQWH------SGRPGDSLLSYLLRSADYQMPLESIRSNIKMTIGGGLNEPRDVL 245 Query: 312 AFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTF 371 + + L + + + L + V +ES+R P Sbjct: 246 GVSTLALLSSSKQLELV------------------LRDPKLWGAVFEESIRWVAPIGMVP 287 Query: 372 RLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFS 431 R +T +DG +P L R + + DP F+ +R + F Sbjct: 288 RQTVVDTELDGYFIPRGAKLGLCILSANRDRSVWSDPDRFDIER-------GSEAHLAFG 340 Query: 432 LGHRSCIGQQFAQMEVK-VVMAKLLQRLE-FRLVPGQR 467 G C+G A+ +V V + L RL+ RL P Q Sbjct: 341 KGVHVCLGAWAARSQVADVGLPALFSRLKGLRLDPNQE 378 >3NV6-A nrPDB Length = 452 Score = 130 bits (327), Expect = 1e-30, Method: Composition-based stats. Identities = 58/417 (13%), Positives = 132/417 (31%), Gaps = 59/417 (14%) Query: 74 VVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYER 133 + I T+ ++VK+ + S L GE+ + ++ + Sbjct: 90 IWTPFTGGH--WIATNGDTVKEVYSDP--TRFSSEVIFLPKEAGEKYQM--VPTKMDPPE 143 Query: 134 WHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILA 193 R+ +D + + + + + E A L++ A+ + ++ LA Sbjct: 144 HTPYRKALDKGLNLAKIRKVEDKVREVASSLIDSFAARGECDFAAEYAELFPVHVFMALA 203 Query: 194 KAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQV 253 + +T + ++ Sbjct: 204 ------------DLPLEDIPVLSEYARQMTRPEGN------TPEEMATDLEAGNNGFYAY 245 Query: 254 GRDWVQRRREALKRGEEVPADILTQILKAEEGAQ--DDEGLLDNFVTFFIAGHETSANHL 311 ++ R D++T ++ +E + + + G +T N L Sbjct: 246 VDPIIRARVGG------DGDDLITLMVNSEINGERIAHDKAQGLISLLLLGGLDTVVNFL 299 Query: 312 AFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTF 371 +F ++ L+R PE+VA L+++ +++ +E R +P Sbjct: 300 SFFMIHLARHPELVAELRSDPLKLMRGA------------------EEMFRRFPVV-SEA 340 Query: 372 RLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFS 431 R++ ++ GV + +L T + G D +P + R ++ F Sbjct: 341 RMVAKDQEYKGVFLKRGDMILLPTALHGLDDAANPEPWKLDFSR-------RSISHSTFG 393 Query: 432 LGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPVLCTLRP 488 G C G A+MEV V + + L+R+ + + ++ V + P Sbjct: 394 GGPHRCAGMHLARMEVIVTLEEWLKRIPEFSFKEGETPIYHSGIVAAVENVPL-VWP 449 >4C9K-A nrPDB Length = 421 Score = 129 bits (325), Expect = 2e-30, Method: Composition-based stats. Identities = 73/457 (15%), Positives = 147/457 (32%), Gaps = 64/457 (14%) Query: 39 PSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGP-----VVRVNVFHKTSVIVTSPESV 93 P + GHL ++ G + Q W + P V I T + Sbjct: 17 PPHVPGHLIREIDAYDLDG-LEQGFHEAWKRVQQPDTPPLVWTPFTGGH--WIATRGTLI 73 Query: 94 KKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSL 153 + S + R + + ++ + R+ ID + + + L Sbjct: 74 DEIYRS----PERFSSRVIWVPREAGEAYDMVPTKLDPPEHTPYRKAIDKGLNLAEIRKL 129 Query: 154 METFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQ 213 + A +++E + + + LA G + Sbjct: 130 EDQIRTIAVEIIEGFADRGHCEFGSEFSTVFPVRVFLALA------------GLPVEDAT 177 Query: 214 AVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPA 273 + L+ +T +Q R + + + + + RR Sbjct: 178 KLGLLANEMTRPSGN------TPEEQGRSLEAANKGFFEYVAPIIAARRGG------SGT 225 Query: 274 DILTQILKAEEGAQD--DEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAE 331 D++T+IL E + D+ L + G +T N L F ++ LSR PE VA ++ E Sbjct: 226 DLITRILNVEIDGKPMPDDRALGLVSLLLLGGLDTVVNFLGFMMIYLSRHPETVAEMRRE 285 Query: 332 VDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPL 391 + L + ++E R + R + + G + + Sbjct: 286 PLK------------------LQRGVEELFRRFAVV-SDARYVVSDMEFHGTMLKEGDLI 326 Query: 392 LFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVM 451 L T + G D + +DP+T + R T+ F+ G C G A++EV V++ Sbjct: 327 LLPTALHGLDDRHHDDPMTVDLSRRD-------VTHSTFAQGPHRCAGMHLARLEVTVML 379 Query: 452 AKLLQRLEFRLVPGQRFGLQEQATLKPLDPVLCTLRP 488 + L R+ + + + + ++ + P Sbjct: 380 QEWLARIPEFRLKDRAVPIYHSGIVAAVENIPLEWEP 416 >2QBO-A nrPDB Length = 421 Score = 129 bits (323), Expect = 4e-30, Method: Composition-based stats. Identities = 52/409 (12%), Positives = 123/409 (30%), Gaps = 64/409 (15%) Query: 85 VIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLA 144 I T + +++ ++ + + + + + R + + Sbjct: 64 WIATRGQLIREAYEDYRHFSSECPFIPREAGEAYDFIP----TSMDPPEQRQFRALANQV 119 Query: 145 FSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSML 204 + L E A L+E L + + + G+ + Sbjct: 120 VGMPVVDKLENRIQELACSLIESLRPQGQCNFTEDYAEPFPIR----IFMLLAGLPEEDI 175 Query: 205 LGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREA 264 + Q + P E +E+ L +++RR+ Sbjct: 176 PHLKYLTDQMTR-----------------PDGSMTFAEAKEA---LYDYLIPIIEQRRQ- 214 Query: 265 LKRGEEVPADILTQILKAEEGAQ--DDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQP 322 + D ++ + + + + + G +T N L+F++ L++ P Sbjct: 215 -----KPGTDAISIVANGQVNGRPITSDEAKRMCGLLLVVGLDTVVNFLSFSMEFLAKSP 269 Query: 323 EIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDG 382 E L + + +E LR + R+L + G Sbjct: 270 EHRQELIERPER------------------IPAACEELLRRFS-LVADGRILTSDYEFHG 310 Query: 383 VRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQF 442 V++ +L + G + P+ + R + ++ F G C+GQ Sbjct: 311 VQLKKGDQILLPQMLSGLDERENACPMHVDFSR-------QKVSHTTFGHGSHLCLGQHL 363 Query: 443 AQMEVKVVMAKLLQRL-EFRLVPGQRFGLQEQATLKPLDPVLCTLRPRG 490 A+ E+ V + + L R+ +F + PG + + + + + P Sbjct: 364 ARREIIVTLKEWLTRIPDFSIAPGAQIQHK-SGIVSGVQALPLVWDPAT 411 >5M0P-A nrPDB Length = 428 Score = 125 bits (314), Expect = 4e-29, Method: Composition-based stats. Identities = 60/414 (14%), Positives = 129/414 (31%), Gaps = 56/414 (13%) Query: 74 VVRVN-VFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYE 132 V + + K V+VT E + F + ++ L L G+G + + + Sbjct: 41 VFQTKALGGKPFVVVTGKEGAEMFYNNDVVQREGM----LPKRIVNTLAGKGAIHTVDGK 96 Query: 133 RWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDIL 192 + R+ + ++ ++ E L + + V++ I+ Sbjct: 97 KH-VDRKALFMSLMTEGNLNY---VRELTRTLWHANTQRMESMDEVNIYRE------SIV 146 Query: 193 AKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQ 252 G + + + + + M + L G K + +E+ R + Sbjct: 147 LLTKVGTRWAGVQAPPEDIERIATDMD-----IMIDSFRALGGAFKGYKASKEARRRVED 201 Query: 253 VGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDEGLLDNFVTF------FIAGHET 306 + + R+ E A L + E+ + + IA Sbjct: 202 WLEEQIIETRKGNIHPPEGTA--LYEFAHWEDYLGNPMDSRTCAIDLMNTFRPLIA---- 255 Query: 307 SANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPP 366 ++F + ++ P ++++E D Y + +E R YP Sbjct: 256 INRFVSFGLHAMNENPITREKIKSEPD------------------YAYKFAQEVRRYYPF 297 Query: 367 AWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFT 426 + + GV +P L Y ++ ++DP F P+RF P F Sbjct: 298 VPFLPGKAKVDIDFQGVTIPAGVGLALDVYGTTHDESLWDDPNEFRPERFETWDGSP-FD 356 Query: 427 YFPFSLGH----RSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATL 476 P G C G+ + ++ M +++ + VP Q + + Sbjct: 357 LIPQGGGDYWTNHRCAGEWITVIIMEETMKYFAEKITYD-VPEQDLEVDLNSIP 409 >2ZQJ-A nrPDB Length = 417 Score = 124 bits (311), Expect = 8e-29, Method: Composition-based stats. Identities = 54/396 (13%), Positives = 121/396 (30%), Gaps = 44/396 (11%) Query: 73 PVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYE 132 + + + K + +T E+ K F + ++ + AL + LFG + + Sbjct: 35 DLFQARLLGKNFICMTGAEAAKVFYDTDRFQRQ----NALPKRVQKSLFGVNAIQGMDGS 90 Query: 133 RWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDIL 192 ++ + + L E E+ + V + + V + + + Sbjct: 91 AHIHRKMLFLSLMTPPHQKRLAELMTEEWKAAV----TRWEKADEVVLFEEAKEILCRVA 146 Query: 193 AKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQ 252 A G+ ++ + + + R + + Sbjct: 147 CYWA-GVPLKE-------------TEVKERADDFIDMVDAFGAVGPRHWKGRRARPRAEE 192 Query: 253 VGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDEGLLDNFVTFFIAGHETSANHLA 312 ++ R L + A E+G+Q D + + + + L Sbjct: 193 WIEVMIEDARAGLLKTTSGTALHEMAFHTQEDGSQLDSRMAAIELINVLRPIVAISYFLV 252 Query: 313 FTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFR 372 F+ + L P+ L++ G+ R ++E R YP Sbjct: 253 FSALALHEHPKYKEWLRS------GNSRER-----------EMFVQEVRRYYPFGPFLGA 295 Query: 373 LLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSL 432 L++++ + + T +L Y ++ P F P+RF F P Sbjct: 296 LVKKDFVWNNCEFKKGTSVLLDLYGTNHDPRLWDHPDEFRPERFAEREENL-FDMIPQGG 354 Query: 433 GH----RSCIGQQFAQMEVKVVMAKLLQRLEFRLVP 464 GH C G+ +K + L+ ++E+ + Sbjct: 355 GHAEKGHRCPGEGITIEVMKASLDFLVHQIEYDVPE 390 >2IJ7-A nrPDB Length = 396 Score = 122 bits (307), Expect = 3e-28, Method: Composition-based stats. Identities = 62/436 (14%), Positives = 137/436 (31%), Gaps = 83/436 (19%) Query: 73 PVVRVN-VFHKTSVIVTSPESVKKFLMSTKYN-----KDSKMYRALQTVFGERLFGQGLV 126 P+ +V + + +V+S + L +++ TV E + G + Sbjct: 30 PIRKVRTITGAEAWLVSSYALCTQVLEDRRFSMKETAAAGAPRLNALTVPPEVVNNMGNI 89 Query: 127 SECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTY 186 ++ R+ + A + + L + + A L++ L P +++ Sbjct: 90 ADAG------LRKAVMKAITPKA-PGLEQFLRDTANSLLDNL---ITEGAPADLRNDFAD 139 Query: 187 TAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRES 246 L G+ + LS A + I A++ Sbjct: 140 PLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKIN------------------ 181 Query: 247 IRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEG----AQDDEGLLDNFVTFFIA 302 + ++ + ++ ++ + + DE VTFF A Sbjct: 182 WDRDIEYMAGILE--------NPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGA 233 Query: 303 GHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLR 362 G ++ + L ++ L ++P++ L + + + ++E LR Sbjct: 234 GVISTGSFLTTALISLIQRPQLRNLLHE------------------KPELIPAGVEELLR 275 Query: 363 L-YPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAP 421 + A G RL + + V V +L +F +P + DR Sbjct: 276 INLSFADGLPRLATADIQVGDVLVRKGELVLVLLEGANFDPEHFPNPGSIELDR------ 329 Query: 422 KPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDP 481 ++ F G C G + ++ + LL+++ PG + P+D Sbjct: 330 PNPTSHLAFGRGQHFCPGSALGRRHAQIGIEALLKKM-----PGVDLAV-------PIDQ 377 Query: 482 VLCTLRPRGWQPAPPP 497 ++ R + P P Sbjct: 378 LVWRTRFQRRIPERLP 393 >5YHJ-A nrPDB Length = 413 Score = 111 bits (277), Expect = 7e-25, Method: Composition-based stats. Identities = 58/424 (13%), Positives = 131/424 (30%), Gaps = 52/424 (12%) Query: 74 VVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYER 133 + + + + + E+ + F + K+ + + L LFG+G V + Sbjct: 36 IFESRLLGERVICLGGEEAAEVFYDANKFTRQDAAPKRLLKT----LFGEGGVQTLDGSE 91 Query: 134 WHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSM-QDMLTYTAMDIL 192 ++++ ++ ++ L+ + Q+ E + + Q++L + Sbjct: 92 HTHRKQMFMSLMTKENIDRLLRLTYREWNQI----ERMGEEIVLYDIAQEVLMKAVCEWS 147 Query: 193 AKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQ 252 E + L ++ + R + R+ ++EVR + + Sbjct: 148 GVPLAKEEVGKRTEEMRLLFESGTSLGPTYLQGRKARSSAEVWIRQMVKEVRSNRLLPNE 207 Query: 253 VGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDEGLLDNFVTFFIAGHETSANHLA 312 + E G E ++ V + + ++ Sbjct: 208 H--TALYEFSWHRD----------------ESGELLPEEVVAVEVLNILRPTVAISVYVL 249 Query: 313 FTVMELSRQPEIVARL-QAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTF 371 FTV+ L + P++ ++ + EV + ++ ++E R YP Sbjct: 250 FTVLALHQFPDVKEQVERGEVSK-------------------TEFVQEVRRFYPFFPVAA 290 Query: 372 RLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFS 431 ++ + DG P T L Y + + +P F+P RF P F + P Sbjct: 291 ARVKTDFEWDGYAFPEGTLTLLDLYGTNHDVSIWTEPDRFDPSRFKDWKESP-FNFIPQG 349 Query: 432 LGH----RSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPVLCTLR 487 G C G+ + V+ + + + P P + T Sbjct: 350 GGDVDFGHRCAGEHVTIAILAQVIELFTKEYAYTVPPQDLSYSFVDMPSLPKSKLRLTHL 409 Query: 488 PRGW 491 R Sbjct: 410 TRNQ 413 >3AWQ-A nrPDB Length = 415 Score = 110 bits (274), Expect = 2e-24, Method: Composition-based stats. Identities = 64/415 (15%), Positives = 119/415 (28%), Gaps = 47/415 (11%) Query: 61 QDVFLDWAKKYG-PVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGER 119 ++ G K + + ++ + F +T++ ++ A+ + Sbjct: 21 YRFISRQCQRLGANAFESRFLLKKTNCLKGAKAAEIFYDTTRFEREG----AMPVAIQKT 76 Query: 120 LFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVS 179 LFGQG V + E ++++ + + +L + F + + V K + Sbjct: 77 LFGQGGVQGLDGETHRHRKQMFMGLMTPERVRALAQLFEAEWRRAVPGWTRKGEIVFYDE 136 Query: 180 MQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQ 239 + + LT E G + L +AS L L +R Sbjct: 137 LHEPLTRAVCAWAGVPLPDDEAGNRAG------ELRALFDAAGSASPRHLWSRLARRRVD 190 Query: 240 LREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDEGLLDNFVTF 299 R A+ + D+L+ + A E + V Sbjct: 191 AWAKRIIEGIRAGSIGSGSGTAAYAIAWHRDRHDDLLSPHVAAVELVNVLRPTVAIAVYI 250 Query: 300 FIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKE 359 H L I A L + D Y ++E Sbjct: 251 TFVAH------------ALQTCSGIRAALVQQPD------------------YAELFVQE 280 Query: 360 SLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPG 419 R YP ++ +G+ P ++ Y + DP F P+RF Sbjct: 281 VRRFYPFFPAVVARASQDFEWEGMAFPEGRQVVLDLYGSNHDAATWADPQEFRPERFRAW 340 Query: 420 APKPRFTYFPFSLGH----RSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGL 470 F + P G C G+ +KV L+ + + VP Q + Sbjct: 341 DED-SFNFIPQGGGDHYLGHRCPGEWIVLAIMKVAAHLLVNAMRYD-VPDQDLSI 393 >2IAG-A nrPDB Length = 482 Score = 105 bits (263), Expect = 3e-23, Method: Composition-based stats. Identities = 78/484 (16%), Positives = 145/484 (29%), Gaps = 41/484 (8%) Query: 36 PPRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKK 95 P P LG +P + G + +K+G + + V + ++ P S Sbjct: 5 PGEPPLDLGSIPWLGYALDFG-KDAASFLTRMKEKHGDIFTILVGGRYVTVLLDPHSYDA 63 Query: 96 FLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLME 155 + + D Y ER+F L + + + L L +L E Sbjct: 64 VVWEPRTRLDFHAYA---IFLMERIFDVQLPHYSPSDEKARMK----LTLLHRELQALTE 116 Query: 156 TFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAV 215 ++ +A +Y+ + L + +Q Sbjct: 117 AMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTL-YGIEALPRTHESQAQD- 174 Query: 216 KLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADI 275 ++ + + L + LP + V + R W L R + Sbjct: 175 RVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWL 234 Query: 276 LTQILKAEEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEV 335 + +L EE +E V A + ++ L + PE +A ++ E++ + Sbjct: 235 ESYLLHLEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESI 294 Query: 336 IGSKRYL-------DFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLI-----DGV 383 + + L L VL ESLRL A R + + + Sbjct: 295 LWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLT-AAPFITREVVVDLAMPMADGREF 353 Query: 384 RVPGNTPLLFST-YVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTY-----------FPFS 431 + LL R + DP F +RF + + P+ Sbjct: 354 NLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWG 413 Query: 432 LGHRSCIGQQFAQMEVKVVMAKLLQRLEFRL------VPGQRFGLQEQATLKPLDPVLCT 485 GH C+G+ +A +K + +L L+ L +P ++P V Sbjct: 414 AGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQPEHDVPVR 473 Query: 486 LRPR 489 R R Sbjct: 474 YRIR 477 >3B98-A nrPDB Length = 475 Score = 105 bits (262), Expect = 5e-23, Method: Composition-based stats. Identities = 68/492 (13%), Positives = 138/492 (28%), Gaps = 58/492 (11%) Query: 25 RARSRYEHIPGPPRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTS 84 R R P G +P E G + +K+G + V Sbjct: 12 RRTRRRNE------PPLDKGMIPWLGHALEFG-KDAAKFLTRMKEKHGDIFTVRAAGLYI 64 Query: 85 VIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLA 144 ++ L + + V +R+F ++ + +++ ++ Sbjct: 65 TVLLDSNCYDAVLSDVASLDQT----SYAQVLMKRIF--NMILPSHNPE--SEKKRAEMH 116 Query: 145 FSRSSLVSLMETFNEKAEQLV--EILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETS 202 F +SL L + L+ + K + ++ FG E + Sbjct: 117 FQGASLTQLSNSMQNNLRLLMTPSEMGLKTSEWKKDGLFNLCYSLLFKTGYLTVFGAENN 176 Query: 203 MLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRR 262 + + + + + T +E ++ R+ W+ Sbjct: 177 NSAAL-TQIYEEFRRFDKLLPKLARTTVN---------KEEKQIASAAREKLWKWLTP-- 224 Query: 263 EALKRGEEVPADILTQILKAEEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQP 322 L R + + + + + ++ D E + + + + L P Sbjct: 225 SGLDRKPREQSWLGSYVKQLQDEGIDAEMQRRAMLLQLWVTQGNAGPAAFWVMGYLLTHP 284 Query: 323 EIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLI-- 380 E + ++ E+ G K E VL E+LRL A R + ++ I Sbjct: 285 EALRAVREEIQ---GGKHLRLEERQKNTPVFDSVLWETLRLTAAAL-ITRDVTQDKKICL 340 Query: 381 ---DGVRVPGNTPLLFSTYVM-GRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRS 436 + L ++ + P F DRF + + F G R Sbjct: 341 SNGQEYHLRRGDRLCVFPFISPQMDPQIHQQPEMFQFDRFLNADRTEKKDF--FKNGARV 398 Query: 437 -------------CIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPVL 483 C G+ FA +K ++ +L R + L + P Sbjct: 399 KYPSVPWGTEDNLCPGRHFAVHAIKELVFTILTRFDVELCD----KNATVPLVDPSRYGF 454 Query: 484 CTLRPRGWQPAP 495 L+P G Sbjct: 455 GILQPAGDLEIR 466 >2RCM-A nrPDB Length = 495 Score = 97.1 bits (240), Expect = 2e-20, Method: Composition-based stats. Identities = 70/459 (15%), Positives = 146/459 (31%), Gaps = 52/459 (11%) Query: 32 HIPGPPRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGP-VVRVNVFH-------KT 83 +IPG ++G + W + ++ F +KY V RVN+ Sbjct: 29 NIPG-NYGLPIVGPIKDRWDY--FYDQGAEEFFKSRIRKYNSTVYRVNMPPGAFIAENPQ 85 Query: 84 SVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWH-KQRRVID 142 V + +S L + + E G ++S + ++ + + Sbjct: 86 VVALLDGKS-FPVLFDVDKVEKKDLLTGTYMPSTELTGGYRILSYLDPSEPKHEKLKNLL 144 Query: 143 LAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETS 202 +SS + F +L + LE + + TA + LA+A +G Sbjct: 145 FFLLKSSRNRIFPEFQATYSELFDSLEKELSLKGKADFGGSSDGTAFNFLARAFYGTNP- 203 Query: 203 MLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRR 262 A L ++ + R + + + + QR Sbjct: 204 ----ADTKLKADAPGLITKWVLFNLHPLLSIGLPRVIEEPLIHTFSLPPALVKSDYQRLY 259 Query: 263 EALKRGEEVPADILTQILKAEEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVME---LS 319 E +++A++ E N A T N + + Sbjct: 260 EFFLESAGEI------LVEADKLGISREEATHN---LLFA---TCFNTWGGMKILFPNMV 307 Query: 320 RQ-----PEIVARLQAEVDEVIGSKR-YLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRL 373 ++ ++ RL E+ VI S L + +++ V+ E LR PP + Sbjct: 308 KRIGRAGHQVHNRLAEEIRSVIKSNGGELTMGAIEKMELTKSVVYECLRFEPPVTAQYGR 367 Query: 374 LEEETLIDGV----RVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFP 429 +++ +I+ +V L + R F+ F P+RF + + Sbjct: 368 AKKDLVIESHDAAFKVKAGEMLYGYQPLATRDPKIFDRADEFVPERFVGEEGEKLLRHVL 427 Query: 430 FSLGH---------RSCIGQQFAQMEVKVVMAKLLQRLE 459 +S G + C G+ F + ++ + ++ +R + Sbjct: 428 WSNGPETETPTVGNKQCAGKDFVVLVARLFVIEIFRRYD 466 >3DBM-A nrPDB Length = 473 Score = 91.7 bits (226), Expect = 7e-19, Method: Composition-based stats. Identities = 76/463 (16%), Positives = 141/463 (30%), Gaps = 59/463 (12%) Query: 32 HIPGPPRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKY-GPVVRVNVFHKTSVIVTSP 90 IPG F GGR + F +KY V R N+ V ++P Sbjct: 10 EIPGSYGIPFFQPIKDRLEYFYGTGGRD--EYFRSRMQKYQSTVFRANMPPGPFVS-SNP 66 Query: 91 ESV-------KKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNY--ERWHKQRRVI 141 + + L + ++ + G ++S + R + + ++ Sbjct: 67 KVIVLLDAKSFPILFDVSKVEKKDLFTGTYMPSTKLTGGYRVLSYLDPSEPRHAQLKNLL 126 Query: 142 DLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMET 201 SS ++ F +L E LEA+ + D+ A L +A F Sbjct: 127 FFMLKNSS-NRVIPQFETTYTELFEGLEAELAKNGKAAFNDVGEQAAFRFLGRAYFNSNP 185 Query: 202 SML-LGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREV---------RESIRFLR 251 LG P + ++ L FL + + + + Sbjct: 186 EETKLGTSAPTLISSWVLFNLAPTLDLGLPWFLQEPLLHTFRLPAFLIKSTYNKLYDYFQ 245 Query: 252 QVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDEGLLDNFVTFFIAGHETSANHL 311 V +++ + +E +IL + G V N L Sbjct: 246 SVATPVMEQAEKLGVPKDEAVHNILFAVCFNTFGG----------VKILFP------NTL 289 Query: 312 AFTVMELSRQPEIVARLQAEVDEVIGS--KRYLDFEDLGRLQYLSQVLKESLRLYPPAWG 369 + + L E+ I S + E + ++ V+ ESLR+ PP Sbjct: 290 KWIGLA-GENLHTQ--LAEEIRGAIKSYGDGNVTLEAIEQMPLTKSVVYESLRIEPPVPP 346 Query: 370 TFRLLEEETLIDGV----RVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRF 425 + + I+ V L + F+ P + PDRF G + Sbjct: 347 QYGKAKSNFTIESHDATFEVKKGEMLFGYQPFATKDPKVFDRPEEYVPDRF-VGDGEALL 405 Query: 426 TYFPFSLGH---------RSCIGQQFAQMEVKVVMAKLLQRLE 459 Y +S G + C G+ F + ++ + +L +R + Sbjct: 406 KYVWWSNGPETESPTVENKQCAGKDFVVLITRLFVIELFRRYD 448 >2YJN-B nrPDB Length = 381 Score = 60.5 bits (145), Expect = 1e-09, Method: Composition-based stats. Identities = 21/127 (16%), Positives = 38/127 (29%), Gaps = 18/127 (14%) Query: 300 FIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKE 359 AG E +AN + V+ +S +P + R+ + + + E Sbjct: 220 LFAGAEMTANTVVDAVLAVSAEPGLAERIADDPAA------------------AQRTVAE 261 Query: 360 SLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPG 419 LRL+P R E + + ++ R F +P + DR Sbjct: 262 VLRLHPALHLERRTATAEVRLGEHVIGEGEEVVVVVAAANRDPEVFAEPDRLDVDRPDAD 321 Query: 420 APKPRFT 426 Sbjct: 322 RALSAHR 328 >3A4L-A nrPDB Length = 260 Score = 34.3 bits (77), Expect = 0.13, Method: Composition-based stats. Identities = 22/220 (10%), Positives = 70/220 (31%), Gaps = 23/220 (10%) Query: 85 VIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECN--YERWHK------ 136 VIV + +++ K + + ++ + L ++ + Y + Sbjct: 35 VIVLGSDLIRESFPVWKEKYEEFIKKSTYRLIDSALKNYWVIVDDTNYYNSMRRDLINIA 94 Query: 137 ----------QRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADG---QTPVSMQDM 183 + R ++ + NE +++ E + P + D Sbjct: 95 KKYNKNYAIIYLKASLDVLIRRNIERGEKIPNEVIKKMYEKFDEPGKKYKWDEPFLIIDT 154 Query: 184 LTYTAMDILAKAAF--GMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLR 241 + +AK E ++ ++ + + +R +++++ K+ Sbjct: 155 TKDIDFNEIAKKLIEKSKEIPKFYVLEENKNKNNNISDKIDKETRKIVSEYIKSKKLDKD 214 Query: 242 EVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILK 281 +++E + ++ + + R + D+L L+ Sbjct: 215 KIKEVVELRKEFLKKIKKMEEVDADRVLKEFKDLLNSYLE 254 >6H7W-B nrPDB Length = 368 Score = 32.0 bits (71), Expect = 0.59, Method: Composition-based stats. Identities = 34/197 (17%), Positives = 65/197 (32%), Gaps = 31/197 (15%) Query: 134 WHKQRRVIDLAF---------SRSSLVSLMETFNEKAEQLVEILEAKADGQ------TPV 178 W RRV A + ++V+ + E A L A + + P+ Sbjct: 157 WFHDRRVYLDALENQLKALLKAMDNMVAQRKAMAEAAADFSASLHALSTVELSPTLSGPL 216 Query: 179 SMQDMLTYTAMDILAK------AAFGMETSMLLGAQKPLSQAVK---LMLEGITASRNTL 229 L D+ + FG+ + + QA ++ + L Sbjct: 217 DALSELQLAIRDVYERQAQQDVLTFGIIIEEYIRLIGSVKQAFSQRQKAFHSWHSAESEL 276 Query: 230 AKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDD 289 K + K LR+ + L QV + + R+ + + ++L++E + Sbjct: 277 MKKKAAQDKLLRQGKTQQDRLNQVNAEVIDAERKVHQARLLFED--MGRLLRSELDRFER 334 Query: 290 EGLLDNFVTFFIAGHET 306 E + D F +G ET Sbjct: 335 EKVED-----FKSGVET 346 >4DJD-D nrPDB Length = 323 Score = 30.9 bits (68), Expect = 1.5, Method: Composition-based stats. Identities = 12/47 (25%), Positives = 19/47 (40%), Gaps = 10/47 (21%) Query: 295 NFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRY 341 AG + L R PE VAR++ +D+++ S Y Sbjct: 287 TATALLQAGAH----------ILLMRHPEAVARVKENIDQLMVSNAY 323 >2WNW-A nrPDB Length = 447 Score = 29.7 bits (65), Expect = 2.7, Method: Composition-based stats. Identities = 16/90 (17%), Positives = 30/90 (33%), Gaps = 16/90 (17%) Query: 413 PDRFGPGAPKPRFTYFPFSLGHRSC----IGQQFAQMEVKVVMAKLLQRLEFRLVPGQRF 468 P ++ R + + +G C G A++ + LL+ + F G+R Sbjct: 351 PIQYDAQNDVLRRNHSWYGIG-HFCRYVRPG---ARVMLSSSYDNLLEEVGFVNPDGERV 406 Query: 469 GL--------QEQATLKPLDPVLCTLRPRG 490 + + L + TL P G Sbjct: 407 LVVYNRDVQERRCRVLDGDKEIALTLPPSG 436 >5OWU-A nrPDB Length = 861 Score = 29.3 bits (64), Expect = 4.4, Method: Composition-based stats. Identities = 23/152 (15%), Positives = 49/152 (32%), Gaps = 10/152 (6%) Query: 157 FNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKP-LSQAV 215 A+ L+ + + + ++D + Y + A G L P L +A+ Sbjct: 591 VEPVADMLMGLFFRLLEKKDSAFIEDDVFYAISALAASL--GKGFEKYLETFSPYLLKAL 648 Query: 216 KLMLEGIT-ASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPAD 274 + ++ + +A + R +++ + RRE V D Sbjct: 649 NQVDSPVSITAVGFIADISNSLEEDFRRYSDAMMNVLAQMISNPNARRELKPAVLSVFGD 708 Query: 275 ILTQILKAEEGAQDDEGLLDNFVTFFIAGHET 306 I + I D L++ + +A T Sbjct: 709 IASNI------GADFIPYLNDIMALCVAAQNT 734 >1ZC1-A nrPDB Length = 208 Score = 29.3 bits (64), Expect = 4.5, Method: Composition-based stats. Identities = 8/30 (26%), Positives = 14/30 (46%) Query: 353 LSQVLKESLRLYPPAWGTFRLLEEETLIDG 382 + Q +E R YP A R+ +++ G Sbjct: 17 MPQTFEEFFRCYPIAMMNDRIRKDDANFGG 46 >5Y77-A nrPDB Length = 473 Score = 28.9 bits (63), Expect = 5.1, Method: Composition-based stats. Identities = 14/65 (21%), Positives = 24/65 (36%), Gaps = 1/65 (1%) Query: 312 AFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTF 371 ++++ SR P A + ++ E + + DL + L V E R PP Sbjct: 404 RYSMVTFSRLPYAQAMARGQIQEQLLKFAVANHSDLTSIN-LDAVEHEVTRCLPPLSHLC 462 Query: 372 RLLEE 376 E Sbjct: 463 AAALE 467 >3WWM-A nrPDB Length = 269 Score = 28.6 bits (62), Expect = 5.9, Method: Composition-based stats. Identities = 17/103 (16%), Positives = 37/103 (35%), Gaps = 9/103 (8%) Query: 280 LKAEEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSK 339 + E D + + T + A E L+ L+R P+ + ++ E I Sbjct: 162 YENEAINTDGDQIAALLATLYGA--EALVY-LSNVPGLLARYPDEASLVREIPVERIEDP 218 Query: 340 RYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDG 382 YL + + + E++R G R++ + ++ Sbjct: 219 EYLALAQGRMKRKVMGAV-EAVR-----GGVKRVVFADARVEN 255 >2F3T-A nrPDB Length = 207 Score = 28.6 bits (62), Expect = 6.3, Method: Composition-based stats. Identities = 23/132 (17%), Positives = 46/132 (34%), Gaps = 18/132 (13%) Query: 37 PRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKF 96 PRP + G F DE + +D FL+ A+ +G + TS E++++ Sbjct: 44 PRPGEVHGEHYFFVNHDEFKEMISRDAFLEHAEVFG-----------NYYGTSREAIEQV 92 Query: 97 LMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMET 156 L + ++ Q + + + + + RR+ R E Sbjct: 93 LATGVDVFLDIDWQGAQQIRQKMPHARS-IFILPPSKIELDRRL------RGRGQDSEEV 145 Query: 157 FNEKAEQLVEIL 168 ++ Q V + Sbjct: 146 IAKRMAQAVAEM 157 >3RP9-A nrPDB Length = 458 Score = 28.6 bits (62), Expect = 6.9, Method: Composition-based stats. Identities = 14/57 (24%), Positives = 18/57 (31%), Gaps = 3/57 (5%) Query: 319 SRQPEIVARLQAEVDEVIGSKRYLDFEDLGRL---QYLSQVLKESLRLYPPAWGTFR 372 P AEV+ K L F D + Q +KE R +P R Sbjct: 395 LAHPFFKEVRIAEVETNATEKVRLPFNDWMNMDEPQLRYAFVKEIQRYHPEIQLPRR 451 >5ZJI-1 nrPDB Length = 245 Score = 28.6 bits (62), Expect = 6.9, Method: Composition-based stats. Identities = 17/60 (28%), Positives = 25/60 (41%) Query: 10 SAVLLAFGLCCTFVHRARSRYEHIPGPPRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAK 69 S L F T R E +PG PRP+ L G P + D +G + + F + + Sbjct: 27 SGRLAPFCANATTSGRVTMSAEWMPGQPRPAHLDGSSPGDFGFDPLGLATVPENFERFKE 86 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.310 0.128 0.335 Lambda K H 0.267 0.0393 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 17,359,179 Number of Sequences: 36641 Number of extensions: 683404 Number of successful extensions: 3198 Number of sequences better than 10.0: 185 Number of HSP's better than 10.0 without gapping: 255 Number of HSP's successfully gapped in prelim test: 68 Number of HSP's that attempted gapping in prelim test: 2186 Number of HSP's gapped (non-prelim): 346 length of query: 500 length of database: 10,336,785 effective HSP length: 101 effective length of query: 399 effective length of database: 6,636,044 effective search space: 2647781556 effective search space used: 2647781556 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.3 bits) S2: 61 (28.2 bits)