BLASTP 2.2.23 [Feb-03-2010]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.


Reference for compositional score matrix adjustment: Altschul, Stephen F., 
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.


Reference for composition-based statistics starting in round 2:
Schaffer, Alejandro A., L. Aravind, Thomas L. Madden,
Sergei Shavirin, John L. Spouge, Yuri I. Wolf,  
Eugene V. Koonin, and Stephen F. Altschul (2001), 
"Improving the accuracy of PSI-BLAST protein database searches with 
composition-based statistics and other refinements",  Nucleic Acids Res. 29:2994-3005.

Query= Q9Y2T3
         (454 letters)

Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 
           36,641 sequences; 10,336,785 total letters

Searching..................................................done


Results from round 1


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

3E0L-A nrPDB                                                          926   0.0  
2I9U-A nrPDB                                                          259   2e-69
2OOD-A nrPDB                                                          169   2e-42
4DYK-A nrPDB                                                          137   9e-33
4DZH-A nrPDB                                                          135   2e-32
4F0R-A nrPDB                                                          120   1e-27
3LNP-A nrPDB                                                          120   1e-27
3HPA-A nrPDB                                                           83   2e-16
2PAJ-A nrPDB                                                           78   8e-15
2PLM-A nrPDB                                                           75   6e-14
4V1Y-A nrPDB                                                           74   1e-13
4LH8-A nrPDB                                                           59   5e-09
3V7P-A nrPDB                                                           55   7e-08
2IMR-A nrPDB                                                           46   4e-05
4F0L-A nrPDB                                                           43   3e-04
1YRR-A nrPDB                                                           32   0.46 
3IV8-A nrPDB                                                           32   0.56 
3MKV-A nrPDB                                                           31   1.2  
2P9B-A nrPDB                                                           30   1.6  
3IEQ-A nrPDB                                                           30   2.3  
5XJN-A nrPDB                                                           30   2.7  
2XP1-A nrPDB                                                           28   7.7  
2XDQ-A nrPDB                                                           28   9.6  
4WHB-E nrPDB                                                           28   9.8  

>3E0L-A nrPDB
          Length = 455

 Score =  926 bits (2392), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 448/454 (98%), Positives = 448/454 (98%), Gaps = 2/454 (0%)

Query: 1   MCAAQMPPLAHIFRGTFVHSTWTCPMEVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCF 60
           MCAAQMPPLAHIFRGTFVHSTWTCPMEVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCF
Sbjct: 4   MCAAQMPPLAHIFRGTFVHSTWTCPMEVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCF 63

Query: 61  KPCEIRELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFA 120
           KPCEIRELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFA
Sbjct: 64  KPCEIRELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFA 123

Query: 121 EEVYTRVVRRTLKNGTTTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEY 180
           EEVYTRVVRRTLKNGTTTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEY
Sbjct: 124 EEVYTRVVRRTLKNGTTTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEY 183

Query: 181 KETTEESIKETERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSH 240
           KETTEESIKETERFVSEMLQKNYSRVKPIVTP      SETLMGELGNIAKTRDLHIQSH
Sbjct: 184 KETTEESIKETERFVSEMLQKNYSRVKPIVTP--GNGVSETLMGELGNIAKTRDLHIQSH 241

Query: 241 ISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAH 300
           ISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAH
Sbjct: 242 ISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAH 301

Query: 301 CPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNE 360
           CPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNE
Sbjct: 302 CPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNE 361

Query: 361 KSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDSPIDLFYGDFFGDI 420
           KSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDSPIDLFYGDFFGDI
Sbjct: 362 KSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDSPIDLFYGDFFGDI 421

Query: 421 SEAVIQKFLYLGDDRNIEEVYVGGKQVVPFSSSV 454
           SEAVIQKFLYLGDDRNIEEVYVGGKQVVPFSSSV
Sbjct: 422 SEAVIQKFLYLGDDRNIEEVYVGGKQVVPFSSSV 455


>2I9U-A nrPDB
          Length = 439

 Score =  259 bits (662), Expect = 2e-69,   Method: Compositional matrix adjust.
 Identities = 167/444 (37%), Positives = 249/444 (56%), Gaps = 37/444 (8%)

Query: 12  IFRGTFVHSTWTCPMEVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPC-EIRELSH 70
           IF+G  + +  +    +++D  + V D GKI     AS    L  ++   P  + R    
Sbjct: 12  IFKGNLIFTKTSDKFTIMKDSYIVVID-GKI-----ASVSSNLPDKYKGNPIIDFR---- 61

Query: 71  HEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRR 130
           +   +PG+ D H HASQY   G  +D  LL WL  YTFP E +F N+D+A++ Y R+++ 
Sbjct: 62  NNIIIPGMNDLHAHASQYKNLGIGMDKELLPWLNNYTFPEEAKFLNVDYAKKTYGRLIKD 121

Query: 131 TLKNGTTTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEY-KETTEESIK 189
            +KNGTT    FAT+H DS++ L ++  K G  A+VGKV MD N   P+Y  E    S+ 
Sbjct: 122 LIKNGTTRVALFATLHKDSTIELFNMLIKSGIGAYVGKVNMDYN--CPDYLTENYITSLN 179

Query: 190 ETERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVE 249
           +TE  + +   K+ + VKPI+TPRF  SCS  LM  LG ++    L +QSH+SEN DE+ 
Sbjct: 180 DTEEIILKYKDKS-NIVKPIITPRFVPSCSNELMDGLGKLSYKYRLPVQSHLSENLDEIA 238

Query: 250 AVKNLYPSYKNYTSVYDKNNLLTNK-TVMAHGCYLSAEELNVFHERGASIAHCPNSNLSL 308
            VK+L+     Y  VYDK  L  N  T+MAH  + S EE+N+      +I HCP SN +L
Sbjct: 239 VVKSLHKKSNFYGEVYDKFGLFGNTPTLMAHCIHSSKEEINLIKRNNVTIVHCPTSNFNL 298

Query: 309 SSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNEKS-----L 363
            SG + V + L   + + LG+D++ G++ S+   I  A+  S I    K  E       L
Sbjct: 299 GSGMMPVRKYLNLGINVVLGSDISAGHTCSLFKVIAYAIQNSKI----KWQESGKKDMFL 354

Query: 364 TLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDSPIDLFYGDFFGDISEA 423
           +  E F +AT  G       G++G+FE G +FDA++IN    DS  +L+  D+  D++E 
Sbjct: 355 STSEAFYMATKKGGSFF---GKVGSFEEGYDFDALVIN----DS--NLYPEDY--DLTER 403

Query: 424 VIQKFLYLGDDRNIEEVYVGGKQV 447
            +++F+YLGDDRNI + YV G ++
Sbjct: 404 -LERFIYLGDDRNIMKRYVCGNEI 426


>2OOD-A nrPDB
          Length = 475

 Score =  169 bits (428), Expect = 2e-42,   Method: Compositional matrix adjust.
 Identities = 121/406 (29%), Positives = 193/406 (47%), Gaps = 29/406 (7%)

Query: 67  ELSH--HEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVY 124
           E++H      +PG +D HIH  Q    G+  +  LL WL K  +P E ++++ ++A E  
Sbjct: 62  EITHIKDRIIVPGFIDGHIHLPQTRVLGAYGEQ-LLPWLQKSIYPEEIKYKDRNYAREGV 120

Query: 125 TRVVRRTLKNGTTTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEYKETT 184
            R +   L  GTTT   F +    ++  L +   +   R   G   +D N    E+ +T 
Sbjct: 121 KRFLDALLAAGTTTCQAFTSSSPVATEELFEEASRRNMRVIAGLTGIDRNAP-AEFIDTP 179

Query: 185 EESIKETERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTR-DLHIQSHISE 243
           E   ++++R +++   K   R    +TPRF+   S  L+     +     D  + +HISE
Sbjct: 180 ENFYRDSKRLIAQYHDK--GRNLYAITPRFAFGASPELLKACQRLKHEHPDCWVNTHISE 237

Query: 244 NRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAHCPN 303
           N  E   V   +P  ++Y  VY+K +L+  K    HG YLS  E     ++GA++  CP 
Sbjct: 238 NPAECSGVLVEHPDCQDYLGVYEKFDLVGPKFSGGHGVYLSNNEFRRMSKKGAAVVFCPC 297

Query: 304 SNLSLSSGFLNVLEVL--KHEVKIGLGTDVAGGYSYSM---LDAIRRAVMVSNILLINKV 358
           SNL L SG   +      +H VK+  GTDV GG  +SM   LD   +  M +N LL   +
Sbjct: 298 SNLFLGSGLFRLGRATDPEHRVKMSFGTDVGGGNRFSMISVLDDAYKVGMCNNTLLDGSI 357

Query: 359 NEKSLTLKEV----------FRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKAS--- 405
           +     L E           F   TLGG++ L +D ++GNFE GKE D + ++P      
Sbjct: 358 DPSRKDLAEAERNKLSPYRGFWSVTLGGAEGLYIDDKLGNFEPGKEADFVALDPNGGQLA 417

Query: 406 ----DSPIDLFYGDFFGDISEAVIQKFLYLGDDRNIEEVYVGGKQV 447
                S I    G    D + +++   + +GDDR ++E +V GK++
Sbjct: 418 QPWHQSLIADGAGPRTVDEAASMLFAVMMVGDDRCVDETWVMGKRL 463


>4DYK-A nrPDB
          Length = 451

 Score =  137 bits (345), Expect = 9e-33,   Method: Compositional matrix adjust.
 Identities = 115/436 (26%), Positives = 198/436 (45%), Gaps = 44/436 (10%)

Query: 21  TWTCPME----VLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMP 76
           TW  P+E    VLRDH LG+ D G+I  +    Q  +          EIREL       P
Sbjct: 15  TWIVPVEPAGVVLRDHALGIRD-GQIALVAPREQAMR------HGATEIRELPGM-LLAP 66

Query: 77  GLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGT 136
           GLV+ H H++   F G + DLPL+ WL  + +PAE ++ + DF  +     +   +K G 
Sbjct: 67  GLVNAHGHSAMSLFRGLADDLPLMTWLQDHIWPAEGQWVSEDFIRDGTELAIAEQVKGGI 126

Query: 137 TTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESIKETERFVS 196
           T    F+ ++     +   + D  G RA V    +D     P  +++  E+I++      
Sbjct: 127 TC---FSDMYFYPQAICGVVHDS-GVRAQVAIPVLDF--PIPGARDSA-EAIRQGMALFD 179

Query: 197 EMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKNLYP 256
           ++  K++ R++    P    + S+  + ++  + +  D  IQ H+ E   EVE  + +  
Sbjct: 180 DL--KHHPRIRIAFGPHAPYTVSDDKLEQILVLTEELDASIQMHVHETAFEVE--QAMER 235

Query: 257 SYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAHCPNSNLSLSSGFLNVL 316
           + +   +   +  LL  +    H   +  ++L +  E  +S+ HCP SNL L+SGF  V 
Sbjct: 236 NGERPLARLHRLGLLGPRFQAVHMTQVDNDDLAMLVETNSSVIHCPESNLKLASGFCPVE 295

Query: 317 EVLKHEVKIGLGTD-VAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATLG 375
           ++ +  V + +GTD  A      +L   R A +++  +        +L      R+ATL 
Sbjct: 296 KLWQAGVNVAIGTDGAASNNDLDLLGETRTAALLAKAVYGQAT---ALDAHRALRMATLN 352

Query: 376 GSQALGLDGEIGNFEVGKEFDAILINPKASDSPIDLFYGDFFGDISEAV---IQKFLYLG 432
           G++ALGL+  IG+ E GK                DL   D  G   + V   + + +Y  
Sbjct: 353 GARALGLERLIGSLEAGKA--------------ADLVAFDLSGLAQQPVYDPVSQLIYAS 398

Query: 433 DDRNIEEVYVGGKQVV 448
               +  V+VGG+Q++
Sbjct: 399 GRDCVRHVWVGGRQLL 414


>4DZH-A nrPDB
          Length = 472

 Score =  135 bits (341), Expect = 2e-32,   Method: Compositional matrix adjust.
 Identities = 113/443 (25%), Positives = 191/443 (43%), Gaps = 55/443 (12%)

Query: 17  FVHSTWTCPME----VLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHE 72
            + + +  P+E    VL DH + VS+   +  L  A  + +      F P   R +S  +
Sbjct: 17  LIEAGYVVPIEPHAVVLEDHAVAVSNGVIVAVLPTADARVR------FAPA--RTVSRPD 68

Query: 73  F-FMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRT 131
              MPGLV+ H H       G + DLPL+ WL ++ +P E      +F  +  T  +   
Sbjct: 69  AALMPGLVNAHTHNPMTLLRGVADDLPLMVWLQQHIWPVEAAVIGPEFVADGTTLAIAEM 128

Query: 132 LKNGTTTAC---YFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESI 188
           L+ GTT      +FA +        A +  + G RA VG V +D    FP     T  + 
Sbjct: 129 LRGGTTCVNENYFFADVQ-------AAVYKQHGFRALVGAVIID----FP-----TAWAS 172

Query: 189 KETERFVSEMLQKNYSRVKPIVTPRFSLSCSETL----MGELGNIAKTRDLHIQSHISEN 244
            + E F       +  R  P+++  F+     T+       +  +A   D+ +  H  E 
Sbjct: 173 SDDEYFARAGELHDQWRDDPLISTAFAPHAPYTVNDANFERVRMLADQLDMPVHLHTHET 232

Query: 245 RDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAHCPNS 304
             EV      Y   +   +  D+  L+ ++ +  H   L+  E+++  ERG S+ HCP S
Sbjct: 233 AQEVADSVAQY--GQRPLARLDRLGLVNDRLIAVHMTQLTEAEIHLCAERGVSVVHCPES 290

Query: 305 NLSLSSGFLNVLEVLKHEVKIGLGTD-VAGGYSYSMLDAIRRAVMVSNILLINKVNEKSL 363
           NL L+SGF     + +  V + +GTD  A      M    R A +++  +     +  +L
Sbjct: 291 NLKLASGFCPACALQRASVNLAIGTDGCASNNDLDMFSENRTAAILAKAV---ANDATAL 347

Query: 364 TLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDS-PIDLFYGDFFGDISE 422
                 R ATLGG++ALG    IG+ EVGK+ D + ++  A ++ P+             
Sbjct: 348 DAATTLRAATLGGARALGFGDRIGSIEVGKQADLVCVDLSALETQPL------------H 395

Query: 423 AVIQKFLYLGDDRNIEEVYVGGK 445
            V+ + +Y      + +V++ GK
Sbjct: 396 HVLSQLIYAAGRHQVTDVWIAGK 418


>4F0R-A nrPDB
          Length = 447

 Score =  120 bits (301), Expect = 1e-27,   Method: Compositional matrix adjust.
 Identities = 102/378 (26%), Positives = 179/378 (47%), Gaps = 27/378 (7%)

Query: 27  EVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHAS 86
           EVL +H + + D GKI  +  A+    L  +      E  EL  H   MPGL++ H H++
Sbjct: 23  EVLENHAIAIRD-GKIAAIIPAADAAGLEAD------ERLELPDH-VLMPGLINLHGHSA 74

Query: 87  QYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTA--CYFAT 144
                G + D  L++WLT Y +P E +  + DF  +     +   ++ GTTT    YF  
Sbjct: 75  MSLLRGLADDKALMDWLTNYIWPTEGKHVHDDFVFDGSLLAMGEMIRGGTTTINDMYFYN 134

Query: 145 IHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFP-EYKETTEESIKETERFVSEMLQKNY 203
                + L +      G R FVG   ++    FP  Y    ++ I +     S+ L ++ 
Sbjct: 135 AAVARAGLAS------GMRTFVGCSILE----FPTNYASNADDYIAKGMAERSQFLGEDL 184

Query: 204 SRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKNLYPSYKNYTS 263
             +   + P    + S+    ++  +A+  D+ I  HI E  DEV    ++    +   +
Sbjct: 185 --LTFTLAPHAPYTVSDDTFRKVVTLAEQEDMLIHCHIHETADEVN--NSVKEHGQRPLA 240

Query: 264 VYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAHCPNSNLSLSSGFLNVLEVLKHEV 323
              +  LL+ + V AH  +L+  E+ +    G S AH P SN+ L+SG   V +++   V
Sbjct: 241 RLQRLGLLSPRLVAAHMVHLNDAEVELAARHGLSTAHNPASNMKLASGISPVSKLMDAGV 300

Query: 324 KIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLD 383
            +G+GTD  G  S + LD +    + + +  +  ++  S+      R+ATL G++ALG+ 
Sbjct: 301 AVGIGTD--GAASNNKLDMLAETRLAALLAKVGTLDPTSVPAAAAIRMATLNGARALGIA 358

Query: 384 GEIGNFEVGKEFDAILIN 401
            ++G+ +VGK+ D I ++
Sbjct: 359 DKVGSVKVGKQADLIALD 376


>3LNP-A nrPDB
          Length = 468

 Score =  120 bits (300), Expect = 1e-27,   Method: Compositional matrix adjust.
 Identities = 117/450 (26%), Positives = 196/450 (43%), Gaps = 62/450 (13%)

Query: 18  VHSTWTCPME----------VLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPC-EIR 66
           ++S W  P+E          +L DH L + D G I+ +E  S         C  P  E  
Sbjct: 27  INSHWIIPIENTTDHNLVSNILIDHCLLIKD-GIILAIEPQSS--------CQIPATETL 77

Query: 67  ELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTR 126
           +L   +  MPG V+ H HA+   F G + DLPL+ WL ++ +PAE +  +  F ++    
Sbjct: 78  DLGQ-QVLMPGWVNAHGHAAMSLFRGLADDLPLMTWLQEHVWPAEAQHVDEHFVKQGTEL 136

Query: 127 VVRRTLKNGTTTAC--YFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFP-EYKET 183
            +   +++GTTT    YF    +  + L A      G RA      +D    FP  Y + 
Sbjct: 137 AIAEMIQSGTTTFADMYFYPQQSGEAALAA------GIRAVCFAPVLD----FPTNYAQN 186

Query: 184 TEESIKET----ERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQS 239
            +E I++     +RF +  + +    V+    P    + S+  + E+  ++   D+ +Q 
Sbjct: 187 ADEYIRKAIECNDRFNNHPMNEQ-GLVQIGFGPHAPYTVSDEPLKEITMLSDQLDMPVQI 245

Query: 240 HISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIA 299
           H+ E   EV   ++L    K  T        L  +    H   +   ++ +  + GASI 
Sbjct: 246 HLHETDFEVS--ESLETFNKRPTQRLADIGFLNERVSCVHMTQVDDGDIKILQKTGASII 303

Query: 300 HCPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVN 359
           HCP SNL L+SGF  + ++    + + +GTD  G  S + LD        +  LL   V+
Sbjct: 304 HCPESNLKLASGFCPIAKLSAANIPLAIGTD--GAASNNDLDMFSETKTAA--LLAKGVS 359

Query: 360 EKSLTLK--EVFRLATLGGSQALGLDGEIGNFEVGKEFD--AILINPKASDSPIDLFYGD 415
           + +  +   E   +ATLGG++ALG+D   G+ + GK  D  AI +N  +S    D     
Sbjct: 360 QDASAIPAIEALTMATLGGARALGIDDITGSLKPGKAADIQAIDLNTLSSQPVFD----- 414

Query: 416 FFGDISEAVIQKFLYLGDDRNIEEVYVGGK 445
                    +   +Y      +  V+V G+
Sbjct: 415 --------PVSHMVYCTKSTQVSHVWVNGR 436


>3HPA-A nrPDB
          Length = 479

 Score = 83.2 bits (204), Expect = 2e-16,   Method: Compositional matrix adjust.
 Identities = 93/382 (24%), Positives = 171/382 (44%), Gaps = 35/382 (9%)

Query: 29  LRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQ- 87
           LRD  L + D+ +IV +  +++  + A E       + +L  H   +PGLV+TH H  Q 
Sbjct: 49  LRDAGLYIEDN-RIVAVGPSAELPETADE-------VLDLRGH-LVIPGLVNTHHHMYQS 99

Query: 88  -YSFAGSSIDLPLLEWLTK-YTFPAEHRFQNIDFAEEVYT-RVVRRTLKNGTTTACYFAT 144
                 ++ +  L  WLT  Y   A    + I    EV T   +   L++G TT+     
Sbjct: 100 LTRAVPAAQNAELFGWLTNLYKIWAHLTPEMI----EVSTLTAMAELLQSGCTTSSDHLY 155

Query: 145 IHTDSSLLLADI--TDKFGQRAFVGKVCMDL---NDTFP--EYKETTEESIKETERFVSE 197
           I+ + S L   I    + G R    +  M +   +   P     E   + +++T+R +  
Sbjct: 156 IYPNGSRLDDSIGAAQRIGMRFHASRGAMSVGQRDGGLPPDSVVEREPDILRDTQRLIET 215

Query: 198 ML-QKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKNLYP 256
              +  Y+ ++ +V P    S S  LM +   +A+   + + +H++EN +++   +    
Sbjct: 216 YHDEGRYAMLRVVVAPCSPFSVSRDLMRDAAVLAREYGVSLHTHLAENVNDIAYSRE--- 272

Query: 257 SYKNYTSVYDKN-NLLTNKTVMAHGCYLSAEELNVFHERGASIAHCPNSNLSLSSGFLNV 315
            +    + Y ++   + +    AH   L    + +F   G  +AHCP SN+ L+SG   V
Sbjct: 273 KFGMTPAEYAEDLGWVGHDVWHAHCVQLDDAGIGLFARTGTGVAHCPCSNMRLASGIAPV 332

Query: 316 LEVLKHEVKIGLGTD-VAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATL 374
            ++    V +GLG D  A      M+  +R+A+++  +         ++T +E   +ATL
Sbjct: 333 KKMRLAGVPVGLGVDGSASNDGAQMVAEVRQALLLQRV----GFGPDAMTAREALEIATL 388

Query: 375 GGSQALGLDGEIGNFEVGKEFD 396
           GG++ L  D +IG  + G   D
Sbjct: 389 GGAKVLNRD-DIGALKPGMAAD 409


>2PAJ-A nrPDB
          Length = 492

 Score = 77.8 bits (190), Expect = 8e-15,   Method: Compositional matrix adjust.
 Identities = 87/357 (24%), Positives = 146/357 (40%), Gaps = 49/357 (13%)

Query: 76  PGLVDTHIHASQYSFAG--SSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLK 133
           P  V+TH H  Q    G  + +D  L  WL    +    RF+ + F E  +    R  L 
Sbjct: 70  PAWVNTHHHLFQSLLKGEPAGLDATLTPWLAATPY----RFRAL-FDERRFRLAARIGLI 124

Query: 134 NGTTTAC---------YFATIHTDSSLLLADITDKFGQRAFV-----GKVCMDLNDTFPE 179
               + C         Y+  +  DSS +L +  +K G R FV           L    P 
Sbjct: 125 ELARSGCATVADHNYVYYPGMPFDSSAILFEEAEKLGLR-FVLLRGGATQTRQLEADLPT 183

Query: 180 --YKETTEESIKETERFVSEMLQKNYSRVKPIV----TPRFSLSCSETLMGELGNIAKTR 233
               ET +  + + ER  +     +   ++ +V    T  +S+S  E  M E   +A+  
Sbjct: 184 ALRPETLDAYVADIERLAARYHDASPRAMRRVVMAPTTVLYSISPRE--MRETAAVARRL 241

Query: 234 DLHIQSHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHE 293
            L + SH+SE     ++  ++Y   K+  +   +++ L +    AH   + A+E+ +  +
Sbjct: 242 GLRMHSHLSETVGYQDSAYSMY--GKSPVAFCGEHDWLGSDVWYAHLVKVDADEIALLAQ 299

Query: 294 RGASIAHCPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMV---- 349
            G  +AHCP SN  L SG   V E+    V + +G D  G  S    D I    M     
Sbjct: 300 TGTGVAHCPQSNGRLGSGICPVREMADAGVPVSIGVD--GAASNEAADMISEVHMTWLAQ 357

Query: 350 -SNILLINKVNEK---------SLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFD 396
            + + ++ +   +         + ++ EV    T GG++ +GLD E+G   VG   D
Sbjct: 358 RARLGMLAQPAYRGGSFEGGAGAASIAEVIHWGTAGGARVMGLD-EVGKVAVGYAAD 413


>2PLM-A nrPDB
          Length = 406

 Score = 75.1 bits (183), Expect = 6e-14,   Method: Compositional matrix adjust.
 Identities = 79/330 (23%), Positives = 128/330 (38%), Gaps = 36/330 (10%)

Query: 75  MPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKN 134
           MP L +TH HA      G + DL   EWL     P E R       +  Y   +   ++ 
Sbjct: 48  MPALFNTHTHAPMTLLRGVAEDLSFEEWLFSKVLPIEDRLTE----KMAYYGTILAQMEM 103

Query: 135 GTTTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESIKETERF 194
                  F  ++     +   + D FG RA + +  +D N       E   +   E   F
Sbjct: 104 ARHGIAGFVDMYFHEEWIAKAVRD-FGMRALLTRGLVDSNGDDGGRLEENLKLYNEWNGF 162

Query: 195 VSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDE---VEAV 251
                     R+     P     CSE  +  + + AK+ +  +  H+ E   E   +E +
Sbjct: 163 --------EGRIFVGFGPHSPYLCSEEYLKRVFDTAKSLNAPVTIHLYETSKEEYDLEDI 214

Query: 252 KNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAHCPNSNLSLSSG 311
            N+               L   KT+ AH  +L      V  +    ++H P SNL L +G
Sbjct: 215 LNI--------------GLKEVKTIAAHCVHLPERYFGVLKDIPFFVSHNPASNLKLGNG 260

Query: 312 FLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRL 371
              V  +++H +K+ LGTD  G  S + L+      + S  LL    N ++L +    ++
Sbjct: 261 IAPVQRMIEHGMKVTLGTD--GAASNNSLNLFFEMRLAS--LLQKAQNPRNLDVNTCLKM 316

Query: 372 ATLGGSQALGLDGEIGNFEVGKEFDAILIN 401
            T  G+QA+G     G  E G   D ++I+
Sbjct: 317 VTYDGAQAMGFKS--GKIEEGWNADLVVID 344


>4V1Y-A nrPDB
          Length = 494

 Score = 74.3 bits (181), Expect = 1e-13,   Method: Compositional matrix adjust.
 Identities = 90/401 (22%), Positives = 162/401 (40%), Gaps = 49/401 (12%)

Query: 27  EVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHAS 86
            VL D  + V D G+IV L        +  E    P +    +  +  +PG ++ H H +
Sbjct: 39  RVLGDSWVHVQD-GRIVAL-------GVHAESVPPPADRVIDARGKVVLPGFINAHTHVN 90

Query: 87  QYSF-AGSSIDLPLLEWLTKYTFPAEH--RFQNIDFAEEVYTRVVRR----TLKNGTTTA 139
           Q     G S      +WL    +P +   R +++  A  +Y     R    T+     +A
Sbjct: 91  QILLRGGPSHGRQFYDWLFNVVYPGQKAMRPEDVAVAVRLYCAEAVRSGITTINENADSA 150

Query: 140 CYFATIHTDSSLLLADITDKFGQRAFVGKVCMD------------LNDTFPEYK--ETTE 185
            Y   I    +     +  + G R    ++  D            L    P+ +     E
Sbjct: 151 IYPGNIEAAMA-----VYGEVGVRVVYARMFFDRMDGRIQGYVDALKARSPQVELCSIME 205

Query: 186 ESIKETERFVSEMLQKNY-----SRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSH 240
           E+    +R  +  L   Y      R+     P  + + +   M      A+ R +    H
Sbjct: 206 ETAVAKDRITA--LSDQYHGTAGGRISVWPAPATTTAVTVEGMRWAQAFARDRAVMWTLH 263

Query: 241 ISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAH 300
           ++E+ D  E +  + P+   Y   Y    LL  +  +AH  Y   +++ + H     +A 
Sbjct: 264 MAES-DHDERIHGMSPA--EYMECY---GLLDERLQVAHCVYFDRKDVRLLHRHNVKVAS 317

Query: 301 CPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNE 360
              SN  L SG   V E+++  + +G+GTD   G S   ++ I     +++I      + 
Sbjct: 318 QVVSNAYLGSGVAPVPEMVERGMAVGIGTD--NGNSNDSVNMIGDMKFMAHIHRAVHRDA 375

Query: 361 KSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILIN 401
             LT +++  +AT+ G+++LG+D EIG+ E GK  D IL++
Sbjct: 376 DVLTPEKILEMATIDGARSLGMDHEIGSIETGKRADLILLD 416


>4LH8-A nrPDB
          Length = 469

 Score = 58.5 bits (140), Expect = 5e-09,   Method: Compositional matrix adjust.
 Identities = 79/346 (22%), Positives = 137/346 (39%), Gaps = 35/346 (10%)

Query: 75  MPGLVDTHIHASQYSFAGSSIDLPLLE------WLTKYTFPAEHRFQNIDFAEEVYTRVV 128
           +PGL+++H    Q+ + G+   +P LE      WL      +   +++  F  +V   V 
Sbjct: 69  LPGLINSH----QHLYEGAMRAIPQLERVTMASWLEGVLTRSAGWWRDGKFGPDVIREVA 124

Query: 129 R----RTLKNGTTTAC----YFATIHTDSSL-LLADITDKFGQRAFVGKVCMDLNDTFPE 179
           R     +L  G TT      +F     DS +    +     G R    +  M L  +  E
Sbjct: 125 RAVLLESLLGGITTVADQHPFFPGATADSYIDATIEAATDLGIRFHAVRSSMTLGKS--E 182

Query: 180 YKETTEESIKETERFVSEMLQ--KNYSRVKPIVTPRFSLS-CS-----ETLMGELGNIAK 231
                +  ++  +R V   L     Y   +P    R +L  C        L      +A 
Sbjct: 183 GGFCDDLFVEPVDRVVQHCLGLIDQYHEPEPFGMVRIALGPCGVPYDKPELFEAFAQMAA 242

Query: 232 TRDLHIQSHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVF 291
             D+ + +H  E  D      +LY          +K+   +++  +AH      EE+  F
Sbjct: 243 DYDVRLHTHFYEPLD-AGMSDHLY--GMTPWRFLEKHGWASDRVWLAHAVVPPREEIPEF 299

Query: 292 HERGASIAHCPNSNLSLSSGFLNVLEVLKHEVKIGLG-TDVAGGYSYSMLDAIRRAVMVS 350
            + G +IAH    +L +  G   + E L   + +G G T  A     ++L  +R A +  
Sbjct: 300 ADAGVAIAHLIAPDLRMGWGLAPIREYLDAGITVGFGTTGSASNDGGNLLGDLRLAALAH 359

Query: 351 NILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFD 396
                N+  EK L+ +E+ R+AT G ++ LG   ++G  E G+  D
Sbjct: 360 RPADPNE-PEKWLSARELLRMATRGSAECLGRP-DLGVLEEGRAAD 403


>3V7P-A nrPDB
          Length = 427

 Score = 54.7 bits (130), Expect = 7e-08,   Method: Compositional matrix adjust.
 Identities = 66/235 (28%), Positives = 99/235 (42%), Gaps = 25/235 (10%)

Query: 192 ERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAV 251
           ERF      +N  R K  V      S    L     +IAK     +  H  E+R E E +
Sbjct: 159 ERFHQSKKHEN-ERFKAAVAIHSPYSVHYILAKRALDIAKKYGSLVSVHFMESRAEREWL 217

Query: 252 -------KNLYPSYKNYTS-VYDKNNLLTN----KTVMAHGCYLSAEELNVFHERGASIA 299
                     +  + N T  V D  + L       T+  H  + + EE+       A I 
Sbjct: 218 DKGSGEFAKFFKEFLNQTRPVNDTKSFLELFKELHTLFVHMVWANEEEIQTIASYNAHII 277

Query: 300 HCPNSNLSLSSGFLNVLEVLKHEVKIGLGTD-VAGGYSYSMLDAIRRAVMVSNILLINKV 358
           HCP SN  L +G L+ LE +K  +   + TD ++  YS +M + ++ A      L ++  
Sbjct: 278 HCPISNRLLGNGVLD-LEKIK-SIPYAIATDGLSSNYSLNMYEELKAA------LFVHPN 329

Query: 359 NEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILIN-PKASDSPIDLF 412
            E +   KE+   AT  G  ALG +G  G   VGK+ D  LI+ P+   +  DL+
Sbjct: 330 KEATTFAKELIIRATKAGYDALGFEG--GEIAVGKDADMQLIDLPEGLTNVEDLY 382


>2IMR-A nrPDB
          Length = 420

 Score = 45.8 bits (107), Expect = 4e-05,   Method: Compositional matrix adjust.
 Identities = 69/327 (21%), Positives = 124/327 (37%), Gaps = 56/327 (17%)

Query: 81  THIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTAC 140
           TH+  S Y F      LP  +W+ +      H  + +  A+     + R  L  G     
Sbjct: 100 THLDMSAYEFQA----LPYFQWIPEVVIRGRH-LRGVAAAQAGADTLTR--LGAGGVGDI 152

Query: 141 YFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPE-YKETTEESIKETERFVSEML 199
            +A    D+ L   D++         G +  ++ + FP+   E    +    ER+    L
Sbjct: 153 VWAPEVMDALLAREDLS---------GTLYFEVLNPFPDKADEVFAAARTHLERW--RRL 201

Query: 200 QKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKN------ 253
           ++   R+   ++P    + S  LM  L + A    L +Q H++E+  E+E  +       
Sbjct: 202 ERPGLRLG--LSPHTPFTVSHRLMRLLSDYAAGEGLPLQIHVAEHPTELEMFRTGGGPLW 259

Query: 254 ------LYP----------SYKNYTSV--YDKNNLLTNKTVMAHGCYLSAEELNVFHERG 295
                 LYP             + T V   D+  +L  +  + H   ++ +++      G
Sbjct: 260 DNRMPALYPHTLAEVIGREPGPDLTPVRYLDELGVLAARPTLVHMVNVTPDDIARVARAG 319

Query: 296 ASIAHCPNSNLSLSSGFLNVLEVLKHEVKIGLGTD-VAGGYSYSMLDAIRRAVMVSNILL 354
            ++  CP SN  L  G  +        V++ LGTD VA G + +    +R  V  +  L 
Sbjct: 320 CAVVTCPRSNHHLECGTFDWPAFAAAGVEVALGTDSVASGETLN----VREEVTFARQLY 375

Query: 355 INKVNEKSLTLKEVFRLATLGGSQALG 381
                   L  + + R A  GG + +G
Sbjct: 376 ------PGLDPRVLVRAAVKGGQRVVG 396


>4F0L-A nrPDB
          Length = 458

 Score = 42.7 bits (99), Expect = 3e-04,   Method: Compositional matrix adjust.
 Identities = 77/339 (22%), Positives = 124/339 (36%), Gaps = 47/339 (13%)

Query: 75  MPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNI-------------DFAE 121
           + G+ + H HA QY  AG          L +   P+   F +              + AE
Sbjct: 58  VAGMANLHSHAFQYGMAG----------LAERRGPSADSFWSWREIMYKFALTMTPEQAE 107

Query: 122 EVYTRVVRRTLKNGTTTACYFATIHTDSSLL----LADITDKFGQRAFVGKVCMDLNDTF 177
            V  R+    L+ G T    F  +H D        L+++ D+    A    + + L   F
Sbjct: 108 AVALRLYVDMLEAGFTRVGEFHYLHHDCDGTPYANLSEMADRIAAAATTAGMGLTLLPVF 167

Query: 178 PEY--------KETTEESIKETERFVS--EMLQKNYSRVKPIVTPRFSLSCSETLMGELG 227
             +         E     I + ERF    E  +K     +  V      S       EL 
Sbjct: 168 YAHSGFGGAAANEGQRRFINDPERFARLIEGCRKTLEGFEGAVLGVAPHSLRAVTPDELD 227

Query: 228 NIAKT-RDLHIQSHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAE 286
           ++ +   D  +  H++E   EVE    +  S K        +  +T +  + H  ++S E
Sbjct: 228 SVTQLLPDAPVHIHVAEQVKEVEDC--IAWSGKRPVEWLLDHQDVTARWCLIHATHMSDE 285

Query: 287 ELNVFHERGASIAHCPNSNLSLSSGFLNVLEVLKHEVKIGLGTD----VAGGYSYSMLDA 342
           E     + GA    CP +  +L  G  N  E      K G+G+D    +  G     L+ 
Sbjct: 286 ETKHMAKAGAIAGLCPVTEANLGDGTFNATEFAAAGGKFGIGSDSNVLIGIGDELRQLEY 345

Query: 343 IRRAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALG 381
            +R    +  +L    NE S T + +F  A LGG+ A+G
Sbjct: 346 SQRLYHRARNVL--AANEGS-TGRALFDGAVLGGNIAMG 381


>1YRR-A nrPDB
          Length = 382

 Score = 32.3 bits (72), Expect = 0.46,   Method: Compositional matrix adjust.
 Identities = 18/60 (30%), Positives = 30/60 (50%), Gaps = 11/60 (18%)

Query: 334 GYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGK 393
           G S +M++ +R           N V    + L EV R+ATL  ++A+G++  +G    GK
Sbjct: 308 GSSLTMIEGVR-----------NLVEHCGIALDEVLRMATLYPARAIGVEKRLGTLAAGK 356


>3IV8-A nrPDB
          Length = 381

 Score = 32.0 bits (71), Expect = 0.56,   Method: Compositional matrix adjust.
 Identities = 17/60 (28%), Positives = 32/60 (53%), Gaps = 11/60 (18%)

Query: 333 GGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVG 392
           GG + +M++A++           N V    + L E  R+ATL  ++A+G+D ++G  + G
Sbjct: 307 GGSALTMIEAVQ-----------NTVEHVGIALDEALRMATLYPAKAIGVDEKLGRIKKG 355


>3MKV-A nrPDB
          Length = 426

 Score = 30.8 bits (68), Expect = 1.2,   Method: Compositional matrix adjust.
 Identities = 46/230 (20%), Positives = 89/230 (38%), Gaps = 31/230 (13%)

Query: 186 ESIKETERFVSEMLQKNYSRVKPIVT--------PRFSLSCSETLMGELGNIAKTRDLHI 237
           + + E  R V E LQ    ++K + +        P      SE  +  +   A+ R  ++
Sbjct: 172 DGVDEVRRAVREELQMGADQIKIMASGGVASPTDPVGVFGYSEDEIRAIVAEAQGRGTYV 231

Query: 238 QSHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEEL--NVFHERG 295
            +H         AV+    + ++   + D+    T + V  HG Y+    +  +     G
Sbjct: 232 LAHAYTPAAIARAVRCGVRTIEHGNLIDDE----TARLVAEHGAYVVPTLVTYDALASEG 287

Query: 296 ASIAHCPNSNLSLS---SGFLNVLEVLKHE-VKIGLGTDVAGGYSYSMLDAIRRAVMVSN 351
                 P S   ++      L+ +E++K   VK+G GTD+ G       D  R       
Sbjct: 288 EKYGLPPESIAKIADVHGAGLHSIEIMKRAGVKMGFGTDLLGEAQRLQSDEFR------- 340

Query: 352 ILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILIN 401
                 +  + L+  EV   AT+  ++ LG+  ++G    G   D ++++
Sbjct: 341 ------ILAEVLSPAEVIASATIVSAEVLGMQDKLGRIVPGAHADVLVVD 384


>2P9B-A nrPDB
          Length = 458

 Score = 30.4 bits (67), Expect = 1.6,   Method: Compositional matrix adjust.
 Identities = 15/40 (37%), Positives = 21/40 (52%)

Query: 367 EVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASD 406
           E    AT   +  LG+D E G+ EVGK  D +++N    D
Sbjct: 373 EALHAATAVNASILGVDAETGSLEVGKSADLLVLNANPLD 412


>3IEQ-A nrPDB
          Length = 183

 Score = 30.0 bits (66), Expect = 2.3,   Method: Compositional matrix adjust.
 Identities = 20/69 (28%), Positives = 32/69 (46%), Gaps = 2/69 (2%)

Query: 122 EVYTRVVRRTLKNGTTTACYFATI--HTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPE 179
           +V+  V  R L  G  T  Y   +  H+D+ +LL  ITD     A +G +    +DT P 
Sbjct: 31  DVHQLVPGRPLIIGGVTIPYERGLLGHSDADVLLHAITDALFGAAALGDIGRHFSDTDPR 90

Query: 180 YKETTEESI 188
           +K     ++
Sbjct: 91  FKGADSRAL 99


>5XJN-A nrPDB
          Length = 455

 Score = 29.6 bits (65), Expect = 2.7,   Method: Compositional matrix adjust.
 Identities = 19/54 (35%), Positives = 24/54 (44%), Gaps = 4/54 (7%)

Query: 137 TTACYFATIHTDSSLLLADITDK----FGQRAFVGKVCMDLNDTFPEYKETTEE 186
           T A  F   H DS  L  D  DK     G  +  G    D+++ FP YKE  +E
Sbjct: 21  TAAAKFERQHMDSPDLGTDDDDKAMADIGSTSHHGYQPFDMHNPFPAYKELRQE 74


>2XP1-A nrPDB
          Length = 178

 Score = 28.1 bits (61), Expect = 7.7,   Method: Compositional matrix adjust.
 Identities = 34/120 (28%), Positives = 49/120 (40%), Gaps = 16/120 (13%)

Query: 95  IDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTACYFATIHTDSSLLLA 154
           + + + E    YT   +H F++ID    VY R + R LK+    A YF +      LL +
Sbjct: 59  VHMKIEEHSEHYTCSNKH-FEDIDEVISVYVRPILRNLKSIKAHAKYFNSPEDAEKLLSS 117

Query: 155 DITDK-----FGQRAFVGKVCMDLNDTFPEYKETTEESIKETERFVSEMLQKNYSRVKPI 209
               K     +  R + GK+    N+           SI E    VS+ML  N S  K I
Sbjct: 118 FDGSKVVYAFYFSRKYPGKLTFAYNNG----------SILEEYIGVSDMLTYNNSTFKDI 167


>2XDQ-A nrPDB
          Length = 460

 Score = 27.7 bits (60), Expect = 9.6,   Method: Compositional matrix adjust.
 Identities = 22/71 (30%), Positives = 31/71 (43%), Gaps = 6/71 (8%)

Query: 61  KPCEIRELSHHEFFMPGLVDTHI-HASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDF 119
           KP    +L   +   P LV T + HA+     G S      +W  ++TF   H F N   
Sbjct: 380 KPDNYNQLQRIKALQPDLVITGMAHANPLEARGIST-----KWSVEFTFAQIHGFGNARD 434

Query: 120 AEEVYTRVVRR 130
             E+ TR +RR
Sbjct: 435 ILELVTRPLRR 445


>4WHB-E nrPDB
          Length = 461

 Score = 27.7 bits (60), Expect = 9.8,   Method: Compositional matrix adjust.
 Identities = 15/47 (31%), Positives = 25/47 (53%)

Query: 360 EKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASD 406
           EK ++  E    AT+  ++A G   +IG+ E GK  D +L++    D
Sbjct: 381 EKGMSPLEAISAATINVARAYGKADQIGSVETGKLADFVLLDQDPVD 427


Searching..................................................done


Results from round 2


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value
Sequences used in model and found again:

3E0L-A nrPDB                                                          609   e-175
2I9U-A nrPDB                                                          395   e-110
3LNP-A nrPDB                                                          384   e-107
4DYK-A nrPDB                                                          379   e-105
2OOD-A nrPDB                                                          363   e-101
4DZH-A nrPDB                                                          361   e-100
4F0R-A nrPDB                                                          354   5e-98
3HPA-A nrPDB                                                          302   2e-82
4V1Y-A nrPDB                                                          291   5e-79
2PLM-A nrPDB                                                          283   1e-76
2PAJ-A nrPDB                                                          261   5e-70
4LH8-A nrPDB                                                          260   1e-69
4F0L-A nrPDB                                                          229   2e-60
3V7P-A nrPDB                                                          205   3e-53
2IMR-A nrPDB                                                          194   6e-50

Sequences not found previously or not previously below threshold:

3MDW-A nrPDB                                                          162   2e-40
2BB0-A nrPDB                                                           84   2e-16
2P9B-A nrPDB                                                           80   2e-15
3MKV-A nrPDB                                                           80   3e-15
4CQD-A nrPDB                                                           78   1e-14
2PUZ-A nrPDB                                                           77   1e-14
2OOF-A nrPDB                                                           76   3e-14
4WGX-A nrPDB                                                           64   1e-10
1R9X-A nrPDB                                                           63   3e-10
3N2C-A nrPDB                                                           61   1e-09
3MTW-A nrPDB                                                           60   2e-09
4WHB-E nrPDB                                                           59   3e-09
4C65-A nrPDB                                                           57   2e-08
2QS8-A nrPDB                                                           54   1e-07
2OGJ-A nrPDB                                                           49   4e-06
3OOQ-A nrPDB                                                           49   5e-06
1XRT-A nrPDB                                                           48   7e-06
1YRR-A nrPDB                                                           44   1e-04
1NFG-A nrPDB                                                           44   1e-04
6NBO-A nrPDB                                                           43   2e-04
6AJD-A nrPDB                                                           43   2e-04
3EWD-A nrPDB                                                           43   2e-04
6II7-A nrPDB                                                           42   4e-04
2AMX-A nrPDB                                                           41   9e-04
2VUN-A nrPDB                                                           41   0.001
3E74-A nrPDB                                                           41   0.001
1YNY-A nrPDB                                                           39   0.005
3IV8-A nrPDB                                                           39   0.006
1GKQ-A nrPDB                                                           38   0.012
3T8L-A nrPDB                                                           36   0.025
4CEX-C nrPDB                                                           36   0.029
2VHL-A nrPDB                                                           36   0.030
5NKS-A nrPDB                                                           36   0.036
3IGH-X nrPDB                                                           36   0.040
4Z42-C nrPDB                                                           35   0.068
3MPG-A nrPDB                                                           34   0.097
1RK6-A nrPDB                                                           34   0.12 
5XGX-A nrPDB                                                           34   0.14 
4LCQ-A nrPDB                                                           34   0.14 
2ICS-A nrPDB                                                           34   0.17 
1E9Y-B nrPDB                                                           33   0.25 
4H9M-A nrPDB                                                           33   0.28 
3SFW-A nrPDB                                                           33   0.33 
3S9V-A nrPDB                                                           33   0.40 
4G7E-B nrPDB                                                           33   0.41 
3TAC-A nrPDB                                                           33   0.44 
4OTK-A nrPDB                                                           32   0.58 
1FWC-C nrPDB                                                           32   0.70 
3QGK-C nrPDB                                                           32   0.75 
4TQT-A nrPDB                                                           31   0.92 
1K1D-A nrPDB                                                           31   0.93 
6HAW-A nrPDB                                                           31   1.3  
3DC8-A nrPDB                                                           31   1.3  
6N91-A nrPDB                                                           31   1.5  
3R64-A nrPDB                                                           30   1.8  
1GKR-A nrPDB                                                           30   1.9  
4YHJ-A nrPDB                                                           30   2.3  
3CKY-A nrPDB                                                           29   3.0  
1C8N-A nrPDB                                                           29   3.1  
2VR2-A nrPDB                                                           29   3.2  
1SQH-A nrPDB                                                           29   3.3  
5NSQ-A nrPDB                                                           29   3.9  
3GIQ-A nrPDB                                                           29   4.0  
6D8G-A nrPDB                                                           29   4.2  
4OJZ-A nrPDB                                                           29   5.2  
1BEV-3 nrPDB                                                           29   6.0  
5YZA-A nrPDB                                                           28   7.0  
4NML-A nrPDB                                                           28   7.8  

>3E0L-A nrPDB
          Length = 455

 Score =  609 bits (1571), Expect = e-175,   Method: Composition-based stats.
 Identities = 448/454 (98%), Positives = 448/454 (98%), Gaps = 2/454 (0%)

Query: 1   MCAAQMPPLAHIFRGTFVHSTWTCPMEVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCF 60
           MCAAQMPPLAHIFRGTFVHSTWTCPMEVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCF
Sbjct: 4   MCAAQMPPLAHIFRGTFVHSTWTCPMEVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCF 63

Query: 61  KPCEIRELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFA 120
           KPCEIRELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFA
Sbjct: 64  KPCEIRELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFA 123

Query: 121 EEVYTRVVRRTLKNGTTTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEY 180
           EEVYTRVVRRTLKNGTTTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEY
Sbjct: 124 EEVYTRVVRRTLKNGTTTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEY 183

Query: 181 KETTEESIKETERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSH 240
           KETTEESIKETERFVSEMLQKNYSRVKPIVTP      SETLMGELGNIAKTRDLHIQSH
Sbjct: 184 KETTEESIKETERFVSEMLQKNYSRVKPIVTP--GNGVSETLMGELGNIAKTRDLHIQSH 241

Query: 241 ISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAH 300
           ISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAH
Sbjct: 242 ISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAH 301

Query: 301 CPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNE 360
           CPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNE
Sbjct: 302 CPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNE 361

Query: 361 KSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDSPIDLFYGDFFGDI 420
           KSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDSPIDLFYGDFFGDI
Sbjct: 362 KSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDSPIDLFYGDFFGDI 421

Query: 421 SEAVIQKFLYLGDDRNIEEVYVGGKQVVPFSSSV 454
           SEAVIQKFLYLGDDRNIEEVYVGGKQVVPFSSSV
Sbjct: 422 SEAVIQKFLYLGDDRNIEEVYVGGKQVVPFSSSV 455


>2I9U-A nrPDB
          Length = 439

 Score =  395 bits (1014), Expect = e-110,   Method: Composition-based stats.
 Identities = 162/439 (36%), Positives = 244/439 (55%), Gaps = 27/439 (6%)

Query: 12  IFRGTFVHSTWTCPMEVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHH 71
           IF+G  + +  +    +++D  + V D GKI     AS    L  ++   P        +
Sbjct: 12  IFKGNLIFTKTSDKFTIMKDSYIVVID-GKI-----ASVSSNLPDKYKGNPI---IDFRN 62

Query: 72  EFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRT 131
              +PG+ D H HASQY   G  +D  LL WL  YTFP E +F N+D+A++ Y R+++  
Sbjct: 63  NIIIPGMNDLHAHASQYKNLGIGMDKELLPWLNNYTFPEEAKFLNVDYAKKTYGRLIKDL 122

Query: 132 LKNGTTTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEY-KETTEESIKE 190
           +KNGTT    FAT+H DS++ L ++  K G  A+VGKV MD N   P+Y  E    S+ +
Sbjct: 123 IKNGTTRVALFATLHKDSTIELFNMLIKSGIGAYVGKVNMDYN--CPDYLTENYITSLND 180

Query: 191 TERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEA 250
           TE  + +   K+ + VKPI+TPRF  SCS  LM  LG ++    L +QSH+SEN DE+  
Sbjct: 181 TEEIILKYKDKS-NIVKPIITPRFVPSCSNELMDGLGKLSYKYRLPVQSHLSENLDEIAV 239

Query: 251 VKNLYPSYKNYTSVYDKNNLLTNK-TVMAHGCYLSAEELNVFHERGASIAHCPNSNLSLS 309
           VK+L+     Y  VYDK  L  N  T+MAH  + S EE+N+      +I HCP SN +L 
Sbjct: 240 VKSLHKKSNFYGEVYDKFGLFGNTPTLMAHCIHSSKEEINLIKRNNVTIVHCPTSNFNLG 299

Query: 310 SGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNEKS-LTLKEV 368
           SG + V + L   + + LG+D++ G++ S+   I  A+  S I       +   L+  E 
Sbjct: 300 SGMMPVRKYLNLGINVVLGSDISAGHTCSLFKVIAYAIQNSKIKWQESGKKDMFLSTSEA 359

Query: 369 FRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDSPIDLFYGDFFGDISEAVIQKF 428
           F +AT  G    G   ++G+FE G +FDA++IN        +L+  D+  D++E  +++F
Sbjct: 360 FYMATKKGGSFFG---KVGSFEEGYDFDALVINDS------NLYPEDY--DLTER-LERF 407

Query: 429 LYLGDDRNIEEVYVGGKQV 447
           +YLGDDRNI + YV G ++
Sbjct: 408 IYLGDDRNIMKRYVCGNEI 426


>3LNP-A nrPDB
          Length = 468

 Score =  384 bits (986), Expect = e-107,   Method: Composition-based stats.
 Identities = 116/463 (25%), Positives = 196/463 (42%), Gaps = 58/463 (12%)

Query: 5   QMPPLAHIFRGTFVHSTWTCPME----------VLRDHLLGVSDSGKIVFLEEASQQEKL 54
           Q  P AH      ++S W  P+E          +L DH L + D G I+ +E  S     
Sbjct: 16  QSQPKAH--ADLRINSHWIIPIENTTDHNLVSNILIDHCLLIKD-GIILAIEPQS----- 67

Query: 55  AKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRF 114
               C  P         +  MPG V+ H HA+   F G + DLPL+ WL ++ +PAE + 
Sbjct: 68  ---SCQIPATETLDLGQQVLMPGWVNAHGHAAMSLFRGLADDLPLMTWLQEHVWPAEAQH 124

Query: 115 QNIDFAEEVYTRVVRRTLKNGTTTAC--YFATIHTDSSLLLADITDKFGQRAFVGKVCMD 172
            +  F ++     +   +++GTTT    YF    +  + L A      G RA      +D
Sbjct: 125 VDEHFVKQGTELAIAEMIQSGTTTFADMYFYPQQSGEAALAA------GIRAVCFAPVLD 178

Query: 173 LNDTFP-EYKETTEESIKET----ERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELG 227
               FP  Y +  +E I++     +RF +  + +    V+    P    + S+  + E+ 
Sbjct: 179 ----FPTNYAQNADEYIRKAIECNDRFNNHPMNEQ-GLVQIGFGPHAPYTVSDEPLKEIT 233

Query: 228 NIAKTRDLHIQSHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEE 287
            ++   D+ +Q H+ E   EV   ++L    K  T        L  +    H   +   +
Sbjct: 234 MLSDQLDMPVQIHLHETDFEVS--ESLETFNKRPTQRLADIGFLNERVSCVHMTQVDDGD 291

Query: 288 LNVFHERGASIAHCPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAV 347
           + +  + GASI HCP SNL L+SGF  + ++    + + +GTD  G  S + LD      
Sbjct: 292 IKILQKTGASIIHCPESNLKLASGFCPIAKLSAANIPLAIGTD--GAASNNDLDMFSETK 349

Query: 348 MVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFD--AILINPKAS 405
             + +      +  ++   E   +ATLGG++ALG+D   G+ + GK  D  AI +N  +S
Sbjct: 350 TAALLAKGVSQDASAIPAIEALTMATLGGARALGIDDITGSLKPGKAADIQAIDLNTLSS 409

Query: 406 DSPIDLFYGDFFGDISEAVIQKFLYLGDDRNIEEVYVGGKQVV 448
               D              +   +Y      +  V+V G+ ++
Sbjct: 410 QPVFD-------------PVSHMVYCTKSTQVSHVWVNGRCLL 439


>4DYK-A nrPDB
          Length = 451

 Score =  379 bits (974), Expect = e-105,   Method: Composition-based stats.
 Identities = 112/439 (25%), Positives = 197/439 (44%), Gaps = 42/439 (9%)

Query: 17  FVHSTWTCPME----VLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHE 72
            +  TW  P+E    VLRDH LG+ D G+I  +    Q  +          EIREL    
Sbjct: 11  LLLPTWIVPVEPAGVVLRDHALGIRD-GQIALVAPREQAMR------HGATEIRELPGM- 62

Query: 73  FFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTL 132
              PGLV+ H H++   F G + DLPL+ WL  + +PAE ++ + DF  +     +   +
Sbjct: 63  LLAPGLVNAHGHSAMSLFRGLADDLPLMTWLQDHIWPAEGQWVSEDFIRDGTELAIAEQV 122

Query: 133 KNGTTTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESIKETE 192
           K G T    F+ ++     +   + D  G RA V    +D     P  +++  E+I++  
Sbjct: 123 KGGITC---FSDMYFYPQAICGVVHDS-GVRAQVAIPVLDF--PIPGARDSA-EAIRQGM 175

Query: 193 RFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVK 252
               ++  K++ R++    P    + S+  + ++  + +  D  IQ H+ E   EVE  +
Sbjct: 176 ALFDDL--KHHPRIRIAFGPHAPYTVSDDKLEQILVLTEELDASIQMHVHETAFEVE--Q 231

Query: 253 NLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAHCPNSNLSLSSGF 312
            +  + +   +   +  LL  +    H   +  ++L +  E  +S+ HCP SNL L+SGF
Sbjct: 232 AMERNGERPLARLHRLGLLGPRFQAVHMTQVDNDDLAMLVETNSSVIHCPESNLKLASGF 291

Query: 313 LNVLEVLKHEVKIGLGTD-VAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRL 371
             V ++ +  V + +GTD  A      +L   R A +++  +        +L      R+
Sbjct: 292 CPVEKLWQAGVNVAIGTDGAASNNDLDLLGETRTAALLAKAVYGQA---TALDAHRALRM 348

Query: 372 ATLGGSQALGLDGEIGNFEVGKEFDAILINPKAS--DSPIDLFYGDFFGDISEAVIQKFL 429
           ATL G++ALGL+  IG+ E GK  D +  +          D              + + +
Sbjct: 349 ATLNGARALGLERLIGSLEAGKAADLVAFDLSGLAQQPVYD-------------PVSQLI 395

Query: 430 YLGDDRNIEEVYVGGKQVV 448
           Y      +  V+VGG+Q++
Sbjct: 396 YASGRDCVRHVWVGGRQLL 414


>2OOD-A nrPDB
          Length = 475

 Score =  363 bits (932), Expect = e-101,   Method: Composition-based stats.
 Identities = 126/441 (28%), Positives = 199/441 (45%), Gaps = 34/441 (7%)

Query: 30  RDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQYS 89
           +D L+ V+D G I       +           P            +PG +D HIH  Q  
Sbjct: 34  QDGLMVVTD-GVIKAFGPYEKIAAAH------PGVEITHIKDRIIVPGFIDGHIHLPQTR 86

Query: 90  FAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTACYFATIHTDS 149
             G+  +  LL WL K  +P E ++++ ++A E   R +   L  GTTT   F +    +
Sbjct: 87  VLGAYGE-QLLPWLQKSIYPEEIKYKDRNYAREGVKRFLDALLAAGTTTCQAFTSSSPVA 145

Query: 150 SLLLADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESIKETERFVSEMLQKNYSRVKPI 209
           +  L +   +   R   G   +D N    E+ +T E   ++++R +++   K   R    
Sbjct: 146 TEELFEEASRRNMRVIAGLTGIDRNAP-AEFIDTPENFYRDSKRLIAQYHDK--GRNLYA 202

Query: 210 VTPRFSLSCSETLMGELGNIAKTR-DLHIQSHISENRDEVEAVKNLYPSYKNYTSVYDKN 268
           +TPRF+   S  L+     +     D  + +HISEN  E   V   +P  ++Y  VY+K 
Sbjct: 203 ITPRFAFGASPELLKACQRLKHEHPDCWVNTHISENPAECSGVLVEHPDCQDYLGVYEKF 262

Query: 269 NLLTNKTVMAHGCYLSAEELNVFHERGASIAHCPNSNLSLSSGFLNVLEVLK--HEVKIG 326
           +L+  K    HG YLS  E     ++GA++  CP SNL L SG   +       H VK+ 
Sbjct: 263 DLVGPKFSGGHGVYLSNNEFRRMSKKGAAVVFCPCSNLFLGSGLFRLGRATDPEHRVKMS 322

Query: 327 LGTDVAGGYSYSM---LDAIRRAVMVSNILLINKVNEKSLTLKEV----------FRLAT 373
            GTDV GG  +SM   LD   +  M +N LL   ++     L E           F   T
Sbjct: 323 FGTDVGGGNRFSMISVLDDAYKVGMCNNTLLDGSIDPSRKDLAEAERNKLSPYRGFWSVT 382

Query: 374 LGGSQALGLDGEIGNFEVGKEFDAILINPKAS-------DSPIDLFYGDFFGDISEAVIQ 426
           LGG++ L +D ++GNFE GKE D + ++P           S I    G    D + +++ 
Sbjct: 383 LGGAEGLYIDDKLGNFEPGKEADFVALDPNGGQLAQPWHQSLIADGAGPRTVDEAASMLF 442

Query: 427 KFLYLGDDRNIEEVYVGGKQV 447
             + +GDDR ++E +V GK++
Sbjct: 443 AVMMVGDDRCVDETWVMGKRL 463


>4DZH-A nrPDB
          Length = 472

 Score =  361 bits (926), Expect = e-100,   Method: Composition-based stats.
 Identities = 109/441 (24%), Positives = 182/441 (41%), Gaps = 51/441 (11%)

Query: 17  FVHSTWTCPME----VLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHE 72
            + + +  P+E    VL DH + VS+   +  L  A  + +      F P          
Sbjct: 17  LIEAGYVVPIEPHAVVLEDHAVAVSNGVIVAVLPTADARVR------FAPARTVSRP-DA 69

Query: 73  FFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTL 132
             MPGLV+ H H       G + DLPL+ WL ++ +P E      +F  +  T  +   L
Sbjct: 70  ALMPGLVNAHTHNPMTLLRGVADDLPLMVWLQQHIWPVEAAVIGPEFVADGTTLAIAEML 129

Query: 133 KNGTTTAC---YFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESIK 189
           + GTT      +FA +        A +  + G RA VG V +D    FP     T  +  
Sbjct: 130 RGGTTCVNENYFFADVQ-------AAVYKQHGFRALVGAVIID----FP-----TAWASS 173

Query: 190 ETERFVSEMLQKNYSRVKP----IVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENR 245
           + E F       +  R  P       P    + ++     +  +A   D+ +  H  E  
Sbjct: 174 DDEYFARAGELHDQWRDDPLISTAFAPHAPYTVNDANFERVRMLADQLDMPVHLHTHETA 233

Query: 246 DEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAHCPNSN 305
            EV      Y   +   +  D+  L+ ++ +  H   L+  E+++  ERG S+ HCP SN
Sbjct: 234 QEVADSVAQY--GQRPLARLDRLGLVNDRLIAVHMTQLTEAEIHLCAERGVSVVHCPESN 291

Query: 306 LSLSSGFLNVLEVLKHEVKIGLGTD-VAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLT 364
           L L+SGF     + +  V + +GTD  A      M    R A +++  +     +  +L 
Sbjct: 292 LKLASGFCPACALQRASVNLAIGTDGCASNNDLDMFSENRTAAILAKAV---ANDATALD 348

Query: 365 LKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDSPIDLFYGDFFGDISEAV 424
                R ATLGG++ALG    IG+ EVGK+ D + ++  A ++                V
Sbjct: 349 AATTLRAATLGGARALGFGDRIGSIEVGKQADLVCVDLSALET-----------QPLHHV 397

Query: 425 IQKFLYLGDDRNIEEVYVGGK 445
           + + +Y      + +V++ GK
Sbjct: 398 LSQLIYAAGRHQVTDVWIAGK 418


>4F0R-A nrPDB
          Length = 447

 Score =  354 bits (907), Expect = 5e-98,   Method: Composition-based stats.
 Identities = 106/438 (24%), Positives = 194/438 (44%), Gaps = 40/438 (9%)

Query: 17  FVHSTWTCPME----VLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHE 72
            + + W   +E    VL +H + + D GKI  +  A+    L  +      E  EL  H 
Sbjct: 9   IISARWIITVETDGEVLENHAIAIRD-GKIAAIIPAADAAGLEAD------ERLELPDH- 60

Query: 73  FFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTL 132
             MPGL++ H H++     G + D  L++WLT Y +P E +  + DF  +     +   +
Sbjct: 61  VLMPGLINLHGHSAMSLLRGLADDKALMDWLTNYIWPTEGKHVHDDFVFDGSLLAMGEMI 120

Query: 133 KNGTTTA--CYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESIKE 190
           + GTTT    YF       + L +      G R FVG   ++       Y    ++ I +
Sbjct: 121 RGGTTTINDMYFYNAAVARAGLAS------GMRTFVGCSILEFPT---NYASNADDYIAK 171

Query: 191 TERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEA 250
                S+ L ++   +   + P    + S+    ++  +A+  D+ I  HI E  DEV  
Sbjct: 172 GMAERSQFLGEDL--LTFTLAPHAPYTVSDDTFRKVVTLAEQEDMLIHCHIHETADEVN- 228

Query: 251 VKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAHCPNSNLSLSS 310
             ++    +   +   +  LL+ + V AH  +L+  E+ +    G S AH P SN+ L+S
Sbjct: 229 -NSVKEHGQRPLARLQRLGLLSPRLVAAHMVHLNDAEVELAARHGLSTAHNPASNMKLAS 287

Query: 311 GFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFR 370
           G   V +++   V +G+GTD  G  S + LD +    + + +  +  ++  S+      R
Sbjct: 288 GISPVSKLMDAGVAVGIGTD--GAASNNKLDMLAETRLAALLAKVGTLDPTSVPAAAAIR 345

Query: 371 LATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDSPIDLFYGDFFGDISEAVIQKFLY 430
           +ATL G++ALG+  ++G+ +VGK+ D I ++    ++                 I   +Y
Sbjct: 346 MATLNGARALGIADKVGSVKVGKQADLIALDLAQLETAPAF-----------DPISHVVY 394

Query: 431 LGDDRNIEEVYVGGKQVV 448
                 +  V+V G+ ++
Sbjct: 395 AAGREQVSHVWVKGRALM 412


>3HPA-A nrPDB
          Length = 479

 Score =  302 bits (774), Expect = 2e-82,   Method: Composition-based stats.
 Identities = 94/432 (21%), Positives = 174/432 (40%), Gaps = 42/432 (9%)

Query: 29  LRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQY 88
           LRD  L + D+ +IV +  +++  + A        E+ +L  H   +PGLV+TH H  Q 
Sbjct: 49  LRDAGLYIEDN-RIVAVGPSAELPETAD-------EVLDLRGH-LVIPGLVNTHHHMYQS 99

Query: 89  SFA--GSSIDLPLLEWLTK-YTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTACYFATI 145
                 ++ +  L  WLT  Y   A    + I+ +       +   L++G TT+     I
Sbjct: 100 LTRAVPAAQNAELFGWLTNLYKIWAHLTPEMIEVS---TLTAMAELLQSGCTTSSDHLYI 156

Query: 146 HTDSSLLLADI--TDKFGQRAFVGKVCMDLNDTFPE-----YKETTEESIKETERFVSEM 198
           + + S L   I    + G R    +  M +             E   + +++T+R +   
Sbjct: 157 YPNGSRLDDSIGAAQRIGMRFHASRGAMSVGQRDGGLPPDSVVEREPDILRDTQRLIETY 216

Query: 199 LQK-NYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKNLYPS 257
             +  Y+ ++ +V P    S S  LM +   +A+   + + +H++EN +++   +     
Sbjct: 217 HDEGRYAMLRVVVAPCSPFSVSRDLMRDAAVLAREYGVSLHTHLAENVNDIAYSR--EKF 274

Query: 258 YKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAHCPNSNLSLSSGFLNVLE 317
                   +    + +    AH   L    + +F   G  +AHCP SN+ L+SG   V +
Sbjct: 275 GMTPAEYAEDLGWVGHDVWHAHCVQLDDAGIGLFARTGTGVAHCPCSNMRLASGIAPVKK 334

Query: 318 VLKHEVKIGLGTD-VAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATLGG 376
           +    V +GLG D  A      M+  +R+A+++  +         ++T +E   +ATLGG
Sbjct: 335 MRLAGVPVGLGVDGSASNDGAQMVAEVRQALLLQRV----GFGPDAMTAREALEIATLGG 390

Query: 377 SQALGLDGEIGNFEVGKEFDAILINPKASDSPIDLFYGDFFGDISEAVIQKFLYLGDDRN 436
           ++ L  D  IG  + G   D    + +             F       +   ++      
Sbjct: 391 AKVLNRDD-IGALKPGMAADFAAFDLR----------QPLFAGALHDPVAALVFCAPS-Q 438

Query: 437 IEEVYVGGKQVV 448
                V GK VV
Sbjct: 439 TAYTVVNGKVVV 450


>4V1Y-A nrPDB
          Length = 494

 Score =  291 bits (744), Expect = 5e-79,   Method: Composition-based stats.
 Identities = 88/403 (21%), Positives = 165/403 (40%), Gaps = 41/403 (10%)

Query: 27  EVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHAS 86
            VL D  + V D G+IV L        +  E    P +    +  +  +PG ++ H H +
Sbjct: 39  RVLGDSWVHVQD-GRIVAL-------GVHAESVPPPADRVIDARGKVVLPGFINAHTHVN 90

Query: 87  QYSFAG-SSIDLPLLEWLTKYTFPAEH--RFQNIDFAEEVYTRVVRRTLKNGTTTACYFA 143
           Q    G  S      +WL    +P +   R +++  A  +Y       +++G TT    A
Sbjct: 91  QILLRGGPSHGRQFYDWLFNVVYPGQKAMRPEDVAVAVRLYC---AEAVRSGITTINENA 147

Query: 144 T--IHTDSSLLLADITDKFGQRAFVGKVCMD------------LNDTFPEYK--ETTEES 187
              I+  +      +  + G R    ++  D            L    P+ +     EE+
Sbjct: 148 DSAIYPGNIEAAMAVYGEVGVRVVYARMFFDRMDGRIQGYVDALKARSPQVELCSIMEET 207

Query: 188 IKETERFVS---EMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISEN 244
               +R  +   +       R+     P  + + +   M      A+ R +    H++E+
Sbjct: 208 AVAKDRITALSDQYHGTAGGRISVWPAPATTTAVTVEGMRWAQAFARDRAVMWTLHMAES 267

Query: 245 RDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAHCPNS 304
            D  E +  + P+   Y   Y    LL  +  +AH  Y   +++ + H     +A    S
Sbjct: 268 -DHDERIHGMSPA--EYMECY---GLLDERLQVAHCVYFDRKDVRLLHRHNVKVASQVVS 321

Query: 305 NLSLSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLT 364
           N  L SG   V E+++  + +G+GTD   G S   ++ I     +++I      +   LT
Sbjct: 322 NAYLGSGVAPVPEMVERGMAVGIGTD--NGNSNDSVNMIGDMKFMAHIHRAVHRDADVLT 379

Query: 365 LKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDS 407
            +++  +AT+ G+++LG+D EIG+ E GK  D IL++ +   +
Sbjct: 380 PEKILEMATIDGARSLGMDHEIGSIETGKRADLILLDLRHPQT 422


>2PLM-A nrPDB
          Length = 406

 Score =  283 bits (723), Expect = 1e-76,   Method: Composition-based stats.
 Identities = 85/408 (20%), Positives = 149/408 (36%), Gaps = 36/408 (8%)

Query: 33  LLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQYSFAG 92
            L + D     F      +    K       ++      +  MP L +TH HA      G
Sbjct: 6   CLILKDFSSEPFWGAVEIENGTIKRVLQGEVKVDLDLSGKLVMPALFNTHTHAPMTLLRG 65

Query: 93  SSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTACYFATIHTDSSLL 152
            + DL   EWL     P E R       +  Y   +   ++        F  ++     +
Sbjct: 66  VAEDLSFEEWLFSKVLPIEDRLTE----KMAYYGTILAQMEMARHGIAGFVDMYFHEEWI 121

Query: 153 LADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESIKETERFVSEMLQKNYSRVKPIVTP 212
              + D FG RA + +  +D N       E   +   E   F          R+     P
Sbjct: 122 AKAVRD-FGMRALLTRGLVDSNGDDGGRLEENLKLYNEWNGF--------EGRIFVGFGP 172

Query: 213 RFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLT 272
                CSE  +  + + AK+ +  +  H+ E   E   ++++               L  
Sbjct: 173 HSPYLCSEEYLKRVFDTAKSLNAPVTIHLYETSKEEYDLEDI-----------LNIGLKE 221

Query: 273 NKTVMAHGCYLSAEELNVFHERGASIAHCPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVA 332
            KT+ AH  +L      V  +    ++H P SNL L +G   V  +++H +K+ LGTD  
Sbjct: 222 VKTIAAHCVHLPERYFGVLKDIPFFVSHNPASNLKLGNGIAPVQRMIEHGMKVTLGTD-- 279

Query: 333 GGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVG 392
           G  S + L+      + S  LL    N ++L +    ++ T  G+QA+G     G  E G
Sbjct: 280 GAASNNSLNLFFEMRLAS--LLQKAQNPRNLDVNTCLKMVTYDGAQAMGFKS--GKIEEG 335

Query: 393 KEFDAILINPK-----ASDSPIDLFYGDFFGDISEAVIQ-KFLYLGDD 434
              D ++I+          +  +     F G++   ++  K++Y   +
Sbjct: 336 WNADLVVIDLDLPEMFPVQNIKNHLVHAFSGEVFATMVAGKWIYFDGE 383


>2PAJ-A nrPDB
          Length = 492

 Score =  261 bits (666), Expect = 5e-70,   Method: Composition-based stats.
 Identities = 91/418 (21%), Positives = 156/418 (37%), Gaps = 46/418 (11%)

Query: 60  FKPCEIRELSHHEFFMPGLVDTHIHASQYSFAG--SSIDLPLLEWLTKYTFPAEHRFQNI 117
            +P E    +      P  V+TH H  Q    G  + +D  L  WL    +     F   
Sbjct: 54  PRPGETIVDATDCVIYPAWVNTHHHLFQSLLKGEPAGLDATLTPWLAATPYRFRALFDER 113

Query: 118 DFAEEVYTRVVRRTLKNGTTTAC-----YFATIHTDSSLLLADITDKFGQRAFV----GK 168
            F        +    ++G  T       Y+  +  DSS +L +  +K G R  +      
Sbjct: 114 RF-RLAARIGLIELARSGCATVADHNYVYYPGMPFDSSAILFEEAEKLGLRFVLLRGGAT 172

Query: 169 VCMDLNDTFPE--YKETTEESIKETERFVSEMLQKNYSRVKPIVTPRFS--LSCSETLMG 224
               L    P     ET +  + + ER  +     +   ++ +V    +   S S   M 
Sbjct: 173 QTRQLEADLPTALRPETLDAYVADIERLAARYHDASPRAMRRVVMAPTTVLYSISPREMR 232

Query: 225 ELGNIAKTRDLHIQSHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLS 284
           E   +A+   L + SH+SE     ++  ++Y   K+  +   +++ L +    AH   + 
Sbjct: 233 ETAAVARRLGLRMHSHLSETVGYQDSAYSMY--GKSPVAFCGEHDWLGSDVWYAHLVKVD 290

Query: 285 AEELNVFHERGASIAHCPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIR 344
           A+E+ +  + G  +AHCP SN  L SG   V E+    V + +G D  G  S    D I 
Sbjct: 291 ADEIALLAQTGTGVAHCPQSNGRLGSGICPVREMADAGVPVSIGVD--GAASNEAADMIS 348

Query: 345 RAVM-----VSNILLINKVNEK---------SLTLKEVFRLATLGGSQALGLDGEIGNFE 390
              M      + + ++ +   +         + ++ EV    T GG++ +GLD E+G   
Sbjct: 349 EVHMTWLAQRARLGMLAQPAYRGGSFEGGAGAASIAEVIHWGTAGGARVMGLD-EVGKVA 407

Query: 391 VGKEFDAILINPKASDSPIDLFYGDFFGDISEAVIQKFLYLGDDRNIEEVYVGGKQVV 448
           VG   D       A     D  Y          V       G   ++  ++  GK+VV
Sbjct: 408 VGYAADI------AVYRLDDPRYFGLHDPAIGPVAS-----GGRPSVMALFSAGKRVV 454


>4LH8-A nrPDB
          Length = 469

 Score =  260 bits (663), Expect = 1e-69,   Method: Composition-based stats.
 Identities = 92/461 (19%), Positives = 160/461 (34%), Gaps = 56/461 (12%)

Query: 12  IFRGTFVHSTWTCPMEVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHH 71
           + RG     T+      L D  + + D  KIV +          K    +          
Sbjct: 16  LIRGLTRVITFDDQERELEDADILI-DGPKIVAVG---------KNLSDRSVSRTIDGRG 65

Query: 72  EFFMPGLVDTHIHASQYSFAGSSIDLPLLE------WLTKYTFPAEHRFQNIDFAEEVYT 125
              +PGL+++H    Q+ + G+   +P LE      WL      +   +++  F  +V  
Sbjct: 66  MIALPGLINSH----QHLYEGAMRAIPQLERVTMASWLEGVLTRSAGWWRDGKFGPDVIR 121

Query: 126 RVVR----RTLKNGTTTAC----YFATIHTDSSL-LLADITDKFGQRAFVGKVCMDLNDT 176
            V R     +L  G TT      +F     DS +    +     G R    +  M L  +
Sbjct: 122 EVARAVLLESLLGGITTVADQHPFFPGATADSYIDATIEAATDLGIRFHAVRSSMTLGKS 181

Query: 177 FPEYKETTEESIKETERFVSEMLQ--------KNYSRVKPIVTPRFSLSCSETLMGELGN 228
             E     +  ++  +R V   L         + +  V+  + P         L      
Sbjct: 182 --EGGFCDDLFVEPVDRVVQHCLGLIDQYHEPEPFGMVRIALGPCGVPYDKPELFEAFAQ 239

Query: 229 IAKTRDLHIQSHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEEL 288
           +A   D+ + +H  E  D      +LY          +K+   +++  +AH      EE+
Sbjct: 240 MAADYDVRLHTHFYEPLD-AGMSDHLY--GMTPWRFLEKHGWASDRVWLAHAVVPPREEI 296

Query: 289 NVFHERGASIAHCPNSNLSLSSGFLNVLEVLKHEVKIGLG-TDVAGGYSYSMLDAIRRAV 347
             F + G +IAH    +L +  G   + E L   + +G G T  A     ++L  +R A 
Sbjct: 297 PEFADAGVAIAHLIAPDLRMGWGLAPIREYLDAGITVGFGTTGSASNDGGNLLGDLRLAA 356

Query: 348 MVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDS 407
           +       N+  EK L+ +E+ R+AT G ++ LG    +G  E G+  D         D 
Sbjct: 357 LAHRPADPNE-PEKWLSARELLRMATRGSAECLGRPD-LGVLEEGRAADIACWRLDGVDR 414

Query: 408 PIDLFYGDFFGDISEAVIQKFLYLGDDRNIEEVYVGGKQVV 448
                                +  G       V V G+ +V
Sbjct: 415 V-----------GVHDPAIGLIMTGLSDRASLVVVNGQVLV 444


>4F0L-A nrPDB
          Length = 458

 Score =  229 bits (583), Expect = 2e-60,   Method: Composition-based stats.
 Identities = 81/410 (19%), Positives = 143/410 (34%), Gaps = 61/410 (14%)

Query: 67  ELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNI--------- 117
           +       + G+ + H HA QY  AG          L +   P+   F +          
Sbjct: 50  DDERQSVVVAGMANLHSHAFQYGMAG----------LAERRGPSADSFWSWREIMYKFAL 99

Query: 118 ----DFAEEVYTRVVRRTLKNGTTTACYFATIHTDSSLL----LADITDKFGQRAFVGKV 169
               + AE V  R+    L+ G T    F  +H D        L+++ D+    A    +
Sbjct: 100 TMTPEQAEAVALRLYVDMLEAGFTRVGEFHYLHHDCDGTPYANLSEMADRIAAAATTAGM 159

Query: 170 CMDLNDTFPEY--------KETTEESIKETERFVS--EMLQKNYSRVKPIVTPRFSLSCS 219
            + L   F  +         E     I + ERF    E  +K     +  V      S  
Sbjct: 160 GLTLLPVFYAHSGFGGAAANEGQRRFINDPERFARLIEGCRKTLEGFEGAVLGVAPHSLR 219

Query: 220 ETLMGELGNIAKTR-DLHIQSHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMA 278
                EL ++ +   D  +  H++E   EVE    +  S K        +  +T +  + 
Sbjct: 220 AVTPDELDSVTQLLPDAPVHIHVAEQVKEVEDC--IAWSGKRPVEWLLDHQDVTARWCLI 277

Query: 279 HGCYLSAEELNVFHERGASIAHCPNSNLSLSSGFLNVLEVLKHEVKIGLGTD----VAGG 334
           H  ++S EE     + GA    CP +  +L  G  N  E      K G+G+D    +  G
Sbjct: 278 HATHMSDEETKHMAKAGAIAGLCPVTEANLGDGTFNATEFAAAGGKFGIGSDSNVLIGIG 337

Query: 335 YSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKE 394
                L+  +R    +  +L      +  T + +F  A LGG+ A+G   +    + G  
Sbjct: 338 DELRQLEYSQRLYHRARNVLAAN---EGSTGRALFDGAVLGGNIAMGRPED--GLKKGAS 392

Query: 395 FDAILINPKASDSPIDLFYGDFFGDISEAVIQKFLYLGDDRNIEEVYVGG 444
            D + ++ +                    V+  +++ G    + +V+V G
Sbjct: 393 ADFVSLDVERLPHAKGDV-----------VLDGWIFAGRAH-VCDVWVRG 430


>3V7P-A nrPDB
          Length = 427

 Score =  205 bits (521), Expect = 3e-53,   Method: Composition-based stats.
 Identities = 87/431 (20%), Positives = 151/431 (35%), Gaps = 53/431 (12%)

Query: 25  PMEVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIH 84
           P  +++D  +      KI  ++      K        P    E   +   +PG  + H+H
Sbjct: 12  PQTIIQDKAVAF--DKKIEAIDTVENLIKKY------PNAAVEHDENSLLLPGFANPHLH 63

Query: 85  ASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTR--VVRRTLKNGTTTACYF 142
               +   +      + WL        HR +++    +       +   ++ GTT     
Sbjct: 64  LEFSANKATLQYGDFIPWLYSVI---RHR-EDLLPLCDGACLEQTLSSIIQTGTTAIGAI 119

Query: 143 ATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESIKETERFVSEMLQKN 202
           +     S             +       +  N    +            ERF      +N
Sbjct: 120 S-----SYGEDLQACIDSALKVVYFNEVIGSNAATADVM-----YASFLERFHQSKKHEN 169

Query: 203 YSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKN-------LY 255
             R K  V      S    L     +IAK     +  H  E+R E E +          +
Sbjct: 170 -ERFKAAVAIHSPYSVHYILAKRALDIAKKYGSLVSVHFMESRAEREWLDKGSGEFAKFF 228

Query: 256 PSYKNYTS-VYDKNNLLTN----KTVMAHGCYLSAEELNVFHERGASIAHCPNSNLSLSS 310
             + N T  V D  + L       T+  H  + + EE+       A I HCP SN  L +
Sbjct: 229 KEFLNQTRPVNDTKSFLELFKELHTLFVHMVWANEEEIQTIASYNAHIIHCPISNRLLGN 288

Query: 311 GFLNVLEVLKHEVKIGLGTD-VAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVF 369
           G L++ ++    +   + TD ++  YS +M + ++ A      L ++   E +   KE+ 
Sbjct: 289 GVLDLEKI--KSIPYAIATDGLSSNYSLNMYEELKAA------LFVHPNKEATTFAKELI 340

Query: 370 RLATLGGSQALGLDGEIGNFEVGKEFDAILIN-PKASDSPIDLFYGDFFGDISEAVIQKF 428
             AT  G  ALG +G  G   VGK+ D  LI+ P+   +  DL+       I      K 
Sbjct: 341 IRATKAGYDALGFEG--GEIAVGKDADMQLIDLPEGLTNVEDLY----LHVILHTTKPKK 394

Query: 429 LYLGDDRNIEE 439
           +Y+  + ++ E
Sbjct: 395 VYIQGEEHVRE 405


>2IMR-A nrPDB
          Length = 420

 Score =  194 bits (493), Expect = 6e-50,   Method: Composition-based stats.
 Identities = 68/355 (19%), Positives = 125/355 (35%), Gaps = 54/355 (15%)

Query: 53  KLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEH 112
               E   +     E        P  V+ H H    ++      LP  +W+ +      H
Sbjct: 70  GHPDELRRQYPHAAEERAGAVIAPPPVNAHTHLDMSAYE--FQALPYFQWIPEVVIRGRH 127

Query: 113 RFQNIDFAEEVYTRVVRRTLKNGTTTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMD 172
             + +  A+     + R  L  G      +A    D+ L   D++         G +  +
Sbjct: 128 -LRGVAAAQAGADTLTR--LGAGGVGDIVWAPEVMDALLAREDLS---------GTLYFE 175

Query: 173 LNDTFPE-YKETTEESIKETERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAK 231
           + + FP+   E    +    ER+    L++   R+   ++P    + S  LM  L + A 
Sbjct: 176 VLNPFPDKADEVFAAARTHLERW--RRLERPGLRL--GLSPHTPFTVSHRLMRLLSDYAA 231

Query: 232 TRDLHIQSHISENRDEVEAVKN------------LYPSYK------------NYTSVYDK 267
              L +Q H++E+  E+E  +             LYP                     D+
Sbjct: 232 GEGLPLQIHVAEHPTELEMFRTGGGPLWDNRMPALYPHTLAEVIGREPGPDLTPVRYLDE 291

Query: 268 NNLLTNKTVMAHGCYLSAEELNVFHERGASIAHCPNSNLSLSSGFLNVLEVLKHEVKIGL 327
             +L  +  + H   ++ +++      G ++  CP SN  L  G  +        V++ L
Sbjct: 292 LGVLAARPTLVHMVNVTPDDIARVARAGCAVVTCPRSNHHLECGTFDWPAFAAAGVEVAL 351

Query: 328 GTD-VAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALG 381
           GTD VA G + +    +R  V  +  L         L  + + R A  GG + +G
Sbjct: 352 GTDSVASGETLN----VREEVTFARQLYP------GLDPRVLVRAAVKGGQRVVG 396


>3MDW-A nrPDB
          Length = 453

 Score =  162 bits (410), Expect = 2e-40,   Method: Composition-based stats.
 Identities = 77/403 (19%), Positives = 158/403 (39%), Gaps = 43/403 (10%)

Query: 71  HEFFMPGLVDTHIHASQYSFAGSSI-----DLPLLEWLTKYTFPAEHRFQNIDFAEEVYT 125
               +PG+ + H HA Q + AG +      +     W  +  +    R  + +  E +  
Sbjct: 45  GGAVLPGMPNLHSHAFQRAMAGLAEVAGNPNDSFWTW-RELMYRMVARL-SPEQIEVIAC 102

Query: 126 RVVRRTLKNGTTTACYFATIHTD----SSLLLADITDKFGQRAFVGKVCMDLNDTFPEYK 181
           ++    LK G T    F  +H D    S    A+++ +  + A    + + L      + 
Sbjct: 103 QLYIEMLKAGYTAVAEFHYVHHDLDGRSYADPAELSLRISRAASAAGIGLTLLPVLYSHA 162

Query: 182 --------ETTEESIKETERFVS--EMLQKNYSRVKPIVTPRFSLSCSETLMGELGNI-- 229
                   E     I  +E ++   + L+         +   F  S       ++  +  
Sbjct: 163 GFGGQPASEGQRRFINGSEAYLELLQRLRAPLEAAGHSLGLCF-HSLRAVTPQQIATVLA 221

Query: 230 AKTRDLHIQSHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELN 289
           A   DL +  HI+E + EV+  +    S +       +N  +  +  + H  +    E+ 
Sbjct: 222 AGHDDLPVHIHIAEQQKEVDDCQA--WSGRRPLQWLYENVAVDQRWCLVHATHADPAEVA 279

Query: 290 VFHERGASIAHCPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMV 349
                GA    C ++  +L  G     + L    ++G+G+D     S S+++ +R     
Sbjct: 280 AMARSGAVAGLCLSTEANLGDGIFPATDFLAQGGRLGIGSD--SHVSLSVVEELRWLEYG 337

Query: 350 SNILLINKV----NEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKAS 405
             +    +     +++ +  + ++  A  GG+QALG    IG+  VG+  D ++++   +
Sbjct: 338 QRLRDRKRNRLYRDDQPMIGRTLYDAALAGGAQALGQP--IGSLAVGRRADLLVLD--GN 393

Query: 406 DSPIDLFYGDFFGDISEAVIQKFLYLGDDRNIEEVYVGGKQVV 448
           D  +    GD       A++ ++L+ G DR + +V V G+ VV
Sbjct: 394 DPYLASAEGD-------ALLNRWLFAGGDRQVRDVMVAGRWVV 429


>2BB0-A nrPDB
          Length = 421

 Score = 83.7 bits (205), Expect = 2e-16,   Method: Composition-based stats.
 Identities = 65/392 (16%), Positives = 128/392 (32%), Gaps = 57/392 (14%)

Query: 26  MEVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHA 85
           + V+ D ++G+ +  KIVF  +   +            +           PGLVD H H 
Sbjct: 32  LHVIEDAVVGIHEQ-KIVFAGQKGAEAGYE-------ADEIIDCSGRLVTPGLVDPHTH- 82

Query: 86  SQYSFAGSSIDLPLLEWLTKYTF-----PAEHRFQNIDFAEEVYTRVVR--------RTL 132
                 G S +  +   L   ++             +          +         R L
Sbjct: 83  ---LVFGGSREKEMNLKLQGISYLDILAQGGGILSTVKDTRAASEEELLQKAHFHLQRML 139

Query: 133 KNGTTTACYF--ATIHTDSSLLLADITDKF--GQRAFVGKVCMDLNDTFPEYKETTEESI 188
             GTTTA       +  ++ L    +  K    Q   +    M  +   PEY+   ++ +
Sbjct: 140 SYGTTTAEVKSGYGLEKETELKQLRVAKKLHESQPVDLVSTFMGAHAIPPEYQNDPDDFL 199

Query: 189 KETERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEV 248
            +    + E+ ++  +    I T     + S++        A      ++ H     DE+
Sbjct: 200 DQMLSLLPEIKEQELASFADIFTETGVFTVSQS--RRYLQKAAEAGFGLKIH----ADEI 253

Query: 249 EAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAHCPNSNLSL 308
           + +     + K                   H    S E +    E G      P +   L
Sbjct: 254 DPLGGAELAGKLKA------------VSADHLVGTSDEGIKKLAEAGTIAVLLPGTTFYL 301

Query: 309 S-SGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKE 367
             S +     ++   V + L TD   G S    + I+  + ++ + L        +T +E
Sbjct: 302 GKSTYARARAMIDEGVCVSLATDFNPGSS--PTENIQLIMSIAALHLK-------MTAEE 352

Query: 368 VFRLATLGGSQALGLDGEIGNFEVGKEFDAIL 399
           ++   T+  + A+G   E G  + G+  D ++
Sbjct: 353 IWHAVTVNAAYAIGKGEEAGQLKAGRSADLVI 384


>2P9B-A nrPDB
          Length = 458

 Score = 79.5 bits (194), Expect = 2e-15,   Method: Composition-based stats.
 Identities = 71/430 (16%), Positives = 125/430 (29%), Gaps = 60/430 (13%)

Query: 27  EVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSH-HEFFMPGLVDTHIHA 85
            +LR+  + V   G+I  +  + +           P E   L    +  MPGL++ H H 
Sbjct: 29  TILRNMTIVVGADGRIEQVAPSIETS--------IPAEYHYLDGTGKIVMPGLINAHTHL 80

Query: 86  SQYSFAGSSIDLPLLEWL-----TKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTAC 140
                   S   PL   L      +      H      +            L++G TT  
Sbjct: 81  F-------SQGKPLNPKLATPKGQRMVATFAHSPLGKPYMAATVKHNATTLLESGVTTIR 133

Query: 141 YFATIHTDSSLLLA--DITDKFGQRAFVGKVCMDL----NDTFPEYKETTEESIKETERF 194
               +  +   L    D     G R       M +              T E  +     
Sbjct: 134 TLGDVGYEVVTLRDQIDAGQILGPRILASGPLMAIPEGHGAPLIALTSGTPEEARTA--- 190

Query: 195 VSEMLQKNYSRVKPI----------VTPRFSLSCSETLMGELGNIAKTRDLHIQSHISEN 244
           V++ L+   + +K            +    S   S   M  + + A    + + +H +++
Sbjct: 191 VAQNLKAGVNAIKIAATGGVTDAQEIGEAGSPQMSVEQMRAICDEAHQYGVIVGAH-AQS 249

Query: 245 RDEVEAVKNLYPSYKNYTSVYDK--NNLLTNKTVMAHG------CYLSAEELNVFHE--R 294
            + V            + SV D     +  +      G         +   L +  +   
Sbjct: 250 PEGVRRSLLAGVDTIEHGSVLDDELIGMFRHNPNALRGYSALIPTLSAGLPLTLLGQDVT 309

Query: 295 GASIAHCPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILL 354
           G +     NS   +        +  +  + IG+GTD                   +   L
Sbjct: 310 GITDIQLENSKNVVGGMVSGARQAHEAGLMIGVGTDTG---------MTFVPQYATWREL 360

Query: 355 INKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDSPIDLFYG 414
              V     +  E    AT   +  LG+D E G+ EVGK  D +++N    D    L + 
Sbjct: 361 ELLVAYAGFSPAEALHAATAVNASILGVDAETGSLEVGKSADLLVLNANPLDDLRALEHP 420

Query: 415 DFFGDISEAV 424
                    V
Sbjct: 421 ALVIAAGHPV 430


>3MKV-A nrPDB
          Length = 426

 Score = 79.5 bits (194), Expect = 3e-15,   Method: Composition-based stats.
 Identities = 58/378 (15%), Positives = 108/378 (28%), Gaps = 44/378 (11%)

Query: 53  KLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEH 112
           +++ +              +  MPGL+D H+H     F     +LP +  L         
Sbjct: 36  EVSDKPIKSSNAHVIDVKGKTIMPGLIDLHVHVVAIEF-----NLPRVATLPNVLVTLRA 90

Query: 113 RFQNIDFAEEVYTRVVRRT-----LKNGTTTACYFATIHTDSSLLLADITDKFGQRAFVG 167
                      +T V          K    +          S   L+        RA   
Sbjct: 91  VPIMRAMLRRGFTTVRDAGGAGYPFKQAVESGLVEGPRLFVSGRALSQTGGHADPRARSD 150

Query: 168 -------KVCMDLNDTFPEYKETTEESIKETERFVSEMLQKNYSRVKPIVT----PRFSL 216
                    C           +  +E  +     +     +        V     P    
Sbjct: 151 YMPPDSPCGCCVRVGALGRVADGVDEVRRAVREELQMGADQIKIMASGGVASPTDPVGVF 210

Query: 217 SCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTV 276
             SE  +  +   A+ R  ++ +H         AV+             +  +  T + V
Sbjct: 211 GYSEDEIRAIVAEAQGRGTYVLAHAYTPAAIARAVR----CGVRTIEHGNLIDDETARLV 266

Query: 277 MAHGCYLSAEEL--NVFHERGASIAHCPNSNLSL----SSGFLNVLEVLKHEVKIGLGTD 330
             HG Y+    +  +     G      P S   +     +G  ++  + +  VK+G GTD
Sbjct: 267 AEHGAYVVPTLVTYDALASEGEKYGLPPESIAKIADVHGAGLHSIEIMKRAGVKMGFGTD 326

Query: 331 VAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFE 390
           + G       D  R                + L+  EV   AT+  ++ LG+  ++G   
Sbjct: 327 LLGEAQRLQSDEFRILA-------------EVLSPAEVIASATIVSAEVLGMQDKLGRIV 373

Query: 391 VGKEFDAILINPKASDSP 408
            G   D ++++     S 
Sbjct: 374 PGAHADVLVVDGNPLKSV 391


>4CQD-A nrPDB
          Length = 423

 Score = 77.6 bits (189), Expect = 1e-14,   Method: Composition-based stats.
 Identities = 66/414 (15%), Positives = 139/414 (33%), Gaps = 38/414 (9%)

Query: 28  VLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQ 87
           ++R+  L   DS   + +    +  K+  +      +  + +      PG VD H H  +
Sbjct: 28  IIRNAYLSEKDSVYDIGIV-GDRIIKIEAKIEGTVKDEID-AKGNLVSPGFVDAHTHMDK 85

Query: 88  YSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTACYFATIHT 147
             F  +   LP   W   YT         + + +      ++R +           T++T
Sbjct: 86  S-FTSTGERLPKF-WSRPYT-RDAAIEDGLKYYKNATHEEIKRHVIEHAHMQVLHGTLYT 142

Query: 148 DSSLLLADITDKFGQRAFV-GKVCMDLNDTFPEYKETTEESIKETERFVSEMLQKNYS-R 205
            + + +  +       A +  K  +                  + E         +    
Sbjct: 143 RTHVDVDSVAKTKAVEAVLEAKEELKDLIDIQVVAFAQSGFFVDLESESLIRKSLDMGCD 202

Query: 206 VKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKNLYPSYKNYTSVY 265
           +   V P    +  E  +     +AK  D+ I  HI +          +Y S        
Sbjct: 203 LVGGVDPATRENNVEGSLDLCFKLAKEYDVDIDYHIHDI-----GTVGVY-SINRLAQKT 256

Query: 266 DKNNLLTNKTVMAHGCYLS------AEELNVFHERGASIAHCPNSNLSLSSGFLNVLEVL 319
            +N      T  A  C+         E + ++ + G     C +S        + V+++L
Sbjct: 257 IENGYKGRVTTSAAWCFADAPSEWLDEAIPLYKDSGMKFVTCFSSTPP----TMPVIKLL 312

Query: 320 KHEVKIGLGTD------VAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLAT 373
           +  + +G  +D      V  G      D ++ A++ +  L +    +  L    ++++ T
Sbjct: 313 EAGINLGCASDNIRDFWVPFGNG----DMVQGALIETQRLELKTNRDLGL----IWKMIT 364

Query: 374 LGGSQALGLDGEIGNFEVGKEFDAILINPKASDSPIDLFYGDFFGDISEAVIQK 427
             G++ LG++   G  EVGK+ D +++N  +    I           +  +I K
Sbjct: 365 SEGARVLGIEKNYG-IEVGKKADLVVLNSLSPQWAIIDQAKRLCVIKNGRIIVK 417


>2PUZ-A nrPDB
          Length = 419

 Score = 77.2 bits (188), Expect = 1e-14,   Method: Composition-based stats.
 Identities = 65/398 (16%), Positives = 118/398 (29%), Gaps = 64/398 (16%)

Query: 29  LRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQY 88
           + + ++ V + G+I F    S              +        +  P L+D H H    
Sbjct: 37  VENAVIAVRN-GRIAFAGPESDLPD-----DLSTADETTDCGGRWITPALIDCHTH---- 86

Query: 89  SFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRR-------------TLKNG 135
              G +  +     L   T+    +      +    TR +                L  G
Sbjct: 87  LVFGGNRAMEFEMRLNGATYEEIAKAGGGIVSSVRDTRALSDEVLVAQALPRLDTLLSEG 146

Query: 136 TTTA----CYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESIKET 191
            +T      Y   I T+  +L      +  +   +    +  + T  +YK    + I + 
Sbjct: 147 VSTIEIKSGYGLDIETELKMLRVARRLETLRPVRIVTSYLAAHATPADYKGRNADYITDV 206

Query: 192 -----ERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRD 246
                E+  +E L          +      S  E     +   A+ R L ++ H +E   
Sbjct: 207 VLPGLEKAHAEGLADAVDGFCEGIA----FSVKEI--DRVFAAAQQRGLPVKLH-AEQLS 259

Query: 247 EVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAHCPNSNL 306
            +              + Y       N     H  YL         + G      P +  
Sbjct: 260 NLG--------GAELAASY-------NALSADHLEYLDETGAKALAKAGTVAVLLPGAFY 304

Query: 307 SL-SSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTL 365
           +L       V  +     +I L TD   G S  +   +    M + +          +T+
Sbjct: 305 ALREKQLPPVQALRDAGAEIALATDCNPGTS-PLTSLLLTMNMGATLFR--------MTV 355

Query: 366 KEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPK 403
           +E     T   ++ALGL  E G  E GK  D  + + +
Sbjct: 356 EECLTATTRNAAKALGLLAETGTLEAGKSADFAIWDIE 393


>2OOF-A nrPDB
          Length = 416

 Score = 76.0 bits (185), Expect = 3e-14,   Method: Composition-based stats.
 Identities = 63/389 (16%), Positives = 127/389 (32%), Gaps = 50/389 (12%)

Query: 28  VLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQ 87
           +L  H LGV + G+I  L      +         P   +++   +   PGL+D H H   
Sbjct: 26  LLEPHALGVHE-GRIHALVPMQDLKG------PYPAHWQDMKG-KLVTPGLIDCHTHLIF 77

Query: 88  YSFAGSSIDLPLLEWLTKYTFPAEH---------RFQNIDFAEEVYTRVVRRTLKNGTTT 138
                   +L                        R  + D   E+    V+  ++ G TT
Sbjct: 78  AGSRAEEFELRQKGVPYAEIARKGGGIISTVRATRAASEDQLFELALPRVKSLIREGVTT 137

Query: 139 ACYF--ATIHTDSSLLLADITDKFG--QRAFVGKVCMDLNDTFPEYKETTEESIKET-ER 193
                   +  +  L +  +  + G      V    +  +   PEY++  +  ++   + 
Sbjct: 138 VEIKSGYGLTLEDELKMLRVARRLGEALPIRVKTTLLAAHAVPPEYRDDPDSWVETICQE 197

Query: 194 FVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKN 253
            +    +   +    +       S ++T   ++   A    L ++ H+            
Sbjct: 198 IIPAAAEAGLADAVDVFCEHIGFSLAQT--EQVYLAADQYGLAVKGHM----------DQ 245

Query: 254 LYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAHCPNSNLSL-SSGF 312
           L     +  +       L+      H  YL  E +     RG      P +   L  +  
Sbjct: 246 LSNLGGSTLA--ANFGALSVD----HLEYLDPEGIQALAHRGVVATLLPTAFYFLKETKL 299

Query: 313 LNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLA 372
             V+ + K  V + + +D+      + + ++R A+ ++  L         LT  E     
Sbjct: 300 PPVVALRKAGVPMAVSSDI--NPGTAPIVSLRMAMNMACTLF-------GLTPVEAMAGV 350

Query: 373 TLGGSQALGLDGEIGNFEVGKEFDAILIN 401
           T   ++ALG   ++G   VG   D ++ N
Sbjct: 351 TRHAARALGEQEQLGQLRVGMLADFLVWN 379


>4WGX-A nrPDB
          Length = 465

 Score = 63.7 bits (153), Expect = 1e-10,   Method: Composition-based stats.
 Identities = 68/462 (14%), Positives = 145/462 (31%), Gaps = 100/462 (21%)

Query: 12  IFRGTFVHSTWTCPMEVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHH 71
           I  GT +      P+    +  + + D G+I  +    Q E         P   +  +  
Sbjct: 7   IVGGTLIDGNGGVPVP---ETTVFIED-GRITKVGSTDQIE-------VHPNIRQIDAQG 55

Query: 72  EFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRT 131
           ++ +PGLV+ ++H            +  L            RF+   +  +V     +  
Sbjct: 56  KWILPGLVNGNVHLLDGIMMMGRGGIEYL-----------ARFEGNYY--KVIEEAAQIA 102

Query: 132 LKNGTTTACYFATIHTDSSLLLADITD--KFGQRAFVGKVCMDLNDTF------PEYKET 183
           L+ G TT           ++    I      G R F     + +   F      P  +  
Sbjct: 103 LRGGVTTVFDTWNALEPVTIARDRIASGAAEGARIFFAGTLIGMGGPFTGDFMRPSMQAR 162

Query: 184 TEESIKETER-----------------------FVSEMLQKNYSRVKPIVTPRFS----- 215
           T  S    +R                        + E L++     K  VT         
Sbjct: 163 TVMSRTFADRMDAMFEVGMGRHLSTLPPAEVRPLIREYLERGVDFCKIAVTDHLVGLLGF 222

Query: 216 ----LSCSETLMGELGNIAKTRDLHIQSHISE-----NRDEVEAVKNLYPS--YKNYTSV 264
                + SE ++  L +  +   + + +H +         E +A   ++ +   +     
Sbjct: 223 RAPYFTFSERVLDVLVDEVRRAGVPLLTHTTSLEGLNTAIERDADLMIHATMTGQAPIPE 282

Query: 265 YDKNNLLTNKTV-------MAHGCYLSAEELNVFHERGASIAHCPNSNLSLSSGFLNVLE 317
                LL  +         +A   ++ + + + F +    + H             N + 
Sbjct: 283 ETIEKLLEKQLWSEVQPTTIAQQAWMDSVD-HPFADFSGRVHH------------ENDVR 329

Query: 318 VLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNI--------LLINKVNEKSLTLKEVF 369
           ++K  V + LGTD AG     +L+ + +  +            + +  + EK +      
Sbjct: 330 MIKAGVPLVLGTD-AGCTDPDILEDMSQGELHERPWTLGEDHFVWMQAMVEKGMDPMAAI 388

Query: 370 RLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDSPIDL 411
              T   ++A     E+G+ +VGK  D ++++        ++
Sbjct: 389 LAGTANPAKAYRKFDELGSIDVGKLGDVVVLDQDPLADITNM 430


>1R9X-A nrPDB
          Length = 430

 Score = 62.9 bits (151), Expect = 3e-10,   Method: Composition-based stats.
 Identities = 53/395 (13%), Positives = 114/395 (28%), Gaps = 55/395 (13%)

Query: 34  LGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQYSFAGS 93
           + + D GKI  ++  S              E    +     +P  V+ HIH      AG 
Sbjct: 26  IHLQD-GKISAIDAQSGVM--------PITENSLDAEQGLVIPPFVEPHIHLDTTQTAGQ 76

Query: 94  ---SIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTACYFATIHTDSS 150
              +    L E +    +         D  ++   + ++  + NG         +   + 
Sbjct: 77  PNWNQSGTLFEGIE--RWAERKALLTHDDVKQRAWQTLKWQIANGIQHVRTHVDVSDATL 134

Query: 151 LLLADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESIKETERFVSEMLQKNYSRVKPIV 210
             L  + +            +DL      + +    S    E  + E L+          
Sbjct: 135 TALKAMLEVK----QEVAPWIDLQIV--AFPQEGILSYPNGEALLEEALR--LGADVVGA 186

Query: 211 TPRFSLSCSE--TLMGELGNIAKTRDLHIQSHISENRDEVEAVKNLYPSYKNYTSVYDKN 268
            P F  +       + +   +A+  D  I  H  E  DE          +    +    +
Sbjct: 187 IPHFEFTREYGVESLHKTFALAQKYDRLIDVHCDEIDDEQSR-------FVETVAALAHH 239

Query: 269 NLLTNKTVMAHGCYL-------SAEELNVFHERGASIAHCPNSNLSLSS---------GF 312
             +  +   +H   +       ++    +    G +    P  N+ L           G 
Sbjct: 240 EGMGARVTASHTTAMHSYNGAYTSRLFRLLKMSGINFVANPLVNIHLQGRFDTYPKRRGI 299

Query: 313 LNVLEVLKHEVKIGLGTDVAGG--YSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFR 370
             V E+L+  + +  G D      Y     + ++   M  ++  +    +    + +   
Sbjct: 300 TRVKEMLESGINVCFGHDGVFDPWYPLGTANMLQVLHMGLHVCQLMGYGQ----INDGLN 355

Query: 371 LATLGGSQALGLDGEIGNFEVGKEFDAILINPKAS 405
           L T   ++ L L         G   + I++  +  
Sbjct: 356 LITHHSARTLNLQDY--GIAAGNSANLIILPAENG 388


>3N2C-A nrPDB
          Length = 423

 Score = 61.0 bits (146), Expect = 1e-09,   Method: Composition-based stats.
 Identities = 65/416 (15%), Positives = 131/416 (31%), Gaps = 47/416 (11%)

Query: 28  VLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQ 87
           VL +H   V D  +IV         ++       P         +  MPG +D H+H   
Sbjct: 20  VLLEHHHVVIDGERIV---------EVTDRPVDLPNAQAIDVRGKTVMPGFIDCHVHVLA 70

Query: 88  Y-SFAGSSIDLP-------LLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTA 139
             +  G +   P        L  L           ++   A+    + V   L +G    
Sbjct: 71  SNANLGVNATQPNILAAIRSLPILDAMLSRGFTSVRDAGGADWSLMQAVETGLVSGPR-- 128

Query: 140 CYFATIHTDSSLLLADITDKFGQRAFVGKVCMD-LNDTFPEYKETTEESIKE-TERFVSE 197
            + +      +    D   +                    +  E    +++E  ++  ++
Sbjct: 129 IFPSGKALSQTGGHGDFRPRGDLLEPCSCCFRTGAIARVVDGVEGVRLAVREEIQKGATQ 188

Query: 198 MLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKNLYPS 257
           +       V     P  +   SE  +  + + A+  + ++ +H    R    AV+     
Sbjct: 189 IKIMASGGVASPTDPIANTQYSEDEIRAIVDEAEAANTYVMAHAYTGRAIARAVR----C 244

Query: 258 YKNYTSVYDKNNLLTNKTVMAHG--CYLSAEELNVFHERGASIAHCPNSNLSLSS----G 311
                   +  +    K +  HG     +    +   + GA     P S   ++S    G
Sbjct: 245 GVRTIEHGNLVDEAAAKLMHEHGAFVVPTLVTYDALAKHGAEFGMPPESVAKVASVQQKG 304

Query: 312 FLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRL 371
             ++       VK+G G+D+ G          R             +  + L   E  R 
Sbjct: 305 RESLEIYANAGVKMGFGSDLLGEMHAFQSGEFR-------------IRAEVLGNLEALRS 351

Query: 372 ATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDSPIDLFYGDFFGDISEAVIQK 427
           AT   ++ + + G++G   VG   D ++++    +   D+      G   E V+Q+
Sbjct: 352 ATTVAAEIVNMQGQLGVIAVGAIADLVVLD---GNPLEDIGVVADEGARVEYVLQR 404


>3MTW-A nrPDB
          Length = 403

 Score = 59.9 bits (143), Expect = 2e-09,   Method: Composition-based stats.
 Identities = 67/423 (15%), Positives = 123/423 (29%), Gaps = 101/423 (23%)

Query: 31  DHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQYSF 90
           D+ L +   G+I  + +                   +L      +PGL+D H+H    + 
Sbjct: 21  DNPLVIVTDGRITSIGKKGDA-------VPAGATAVDLPG-VTLLPGLIDMHVHLDSLAE 72

Query: 91  AGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTACYFATIHTDSS 150
            G    L               RF ++     V T   ++TL+ G TT         D  
Sbjct: 73  VGGYNSLEY-----------SDRFWSV-----VQTANAKKTLEAGFTTVRNVGAADYDDV 116

Query: 151 LLLADITDKF--GQRAFVGK----------------VCMDLNDTF-PEYKETTEESIKET 191
            L   I   +  G R                       MD  + F  +  +   ++++  
Sbjct: 117 GLREAIDAGYVPGPRIVTAAISFGATGGHCDSTFFPPSMDQKNPFNSDSPDEARKAVRTL 176

Query: 192 ERFVSEMLQ--KNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVE 249
           +++ +++++             P      +   M  + + A    + + +H        E
Sbjct: 177 KKYGAQVIKICATGGVFSRGNEP-GQQQLTYEEMKAVVDEAHMAGIKVAAHAHGASGIRE 235

Query: 250 AVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAHCP------- 302
           AV+       +                  H   +  E + +  ++GA  +          
Sbjct: 236 AVRA----GVDTIE---------------HASLVDDEGIKLAVQKGAYFSMDIYNTDYTQ 276

Query: 303 ---NSNLSLSSGF-----------LNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVM 348
                N  L                N  + LK  VK+  GTD                V 
Sbjct: 277 AEGKKNGVLEDNLRKDRDIGELQRENFRKALKAGVKMVYGTDAGIYPHGDNAKQFAVMVR 336

Query: 349 VSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDSP 408
                          T  +  + ATL  ++ALG   ++G   VG+  D I +   A D  
Sbjct: 337 Y------------GATPLQAIQSATLTAAEALGRSKDVGQVAVGRYGDMIAV---AGDPL 381

Query: 409 IDL 411
            D+
Sbjct: 382 ADV 384


>4WHB-E nrPDB
          Length = 461

 Score = 59.5 bits (142), Expect = 3e-09,   Method: Composition-based stats.
 Identities = 63/429 (14%), Positives = 126/429 (29%), Gaps = 63/429 (14%)

Query: 30  RDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHA--SQ 87
           R     + +  +   +  +                     +  + +PG V+ ++H   + 
Sbjct: 20  RPATTVIVEGDRFATVGPSDSTP-------VPEGATVVDGNRRWMVPGYVNGNVHLLDAW 72

Query: 88  YSFAGSSIDLPLLEWLTKYT--FPAEHRFQNIDFAEEVYT--------RVVRRTLKNGTT 137
              AG      L  W  +Y        +    +    V+            R  +  G +
Sbjct: 73  MFMAGPGTIEYLARWEGRYVEVIEEAAQLALRNGVTTVFDTHNAIEPVLAARDRINAGIS 132

Query: 138 TAC-YFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESI---KETER 193
                FA                F  R    +  +D  D+  E     + S+   KE   
Sbjct: 133 QGARIFAAGTIVGMGGPFSADFHFAGRTAATRTFVDRIDSMFEAGVGHQLSLLPRKEVRA 192

Query: 194 FVSEMLQKNYSRVKPIVTPRFSLSC--------------SETLMGELGNIAKTRDLHIQS 239
            V + L +    +K  V+     +               S  ++  +   A+   + + +
Sbjct: 193 RVRDYLSRGVDMLKIAVSDHIVFTLVDRSVGFDRSYQTFSRPVLEVMVEEARAAGVPVLT 252

Query: 240 H-----ISENRDEVEA---VKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCY-LSAEELNV 290
           H       +   E+ A   +   Y   +   +      + ++        +    + L  
Sbjct: 253 HSVSVEALDTSVELGADVLIHANYTLGQEIPNYLIDKIVASDSWAGLQTVHDQHRQGLED 312

Query: 291 FHERGASIAHCPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVS 350
                A++A  P +         N   ++    KI L TD AG  S   L  +       
Sbjct: 313 VGSWAAALAGEPYAT--------NERNLISANAKILLNTD-AGCPSKDHLADLSPVERED 363

Query: 351 NI--------LLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINP 402
                          + EK ++  E    AT+  ++A G   +IG+ E GK  D +L++ 
Sbjct: 364 RPWTIGNDHFHWTQSMVEKGMSPLEAISAATINVARAYGKADQIGSVETGKLADFVLLDQ 423

Query: 403 KASDSPIDL 411
              D   +L
Sbjct: 424 DPVDDIRNL 432


>4C65-A nrPDB
          Length = 438

 Score = 56.8 bits (135), Expect = 2e-08,   Method: Composition-based stats.
 Identities = 76/467 (16%), Positives = 139/467 (29%), Gaps = 88/467 (18%)

Query: 14  RGTFVHSTWTCPM--EVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHH 71
           + T +++    P   E LR+  L +SD   I F+   +   K           +      
Sbjct: 6   KVTIIYAGLLIPGDGEPLRNAALVISDK-IIAFVGSEADIPKKYLRSTQSTHRV------ 58

Query: 72  EFFMPGLVDTHIHASQYSFAGSSIDL--PLLEWLTKYTFPAEHRFQN--IDFAEEVYTRV 127
              MPGL D H+H       G   D        L  +   +  R      +  +  YT  
Sbjct: 59  PVLMPGLWDCHMHF------GGDDDYYNDYTSGLATHPASSGARLARGCWEALQNGYT-S 111

Query: 128 VRRTLKNGT-------TTACYFATIHTDSSLL--LADITDKFGQRAFVGKVCMDLNDTFP 178
            R     G                +++  + L   A   D F   A        + +  P
Sbjct: 112 YRDLAGYGCEVAKAINDGTIVGPNVYSSGAALSQTAGHGDIFALPAGEVLGSYGVMNPRP 171

Query: 179 EYKETTEESIKETERFVSEMLQKNYSRVKPIVTPRFSLSC------------SETLMGEL 226
            Y       I +    V   ++    R   ++    S               S   +  +
Sbjct: 172 GYWGAGPLCIADGVEEVRRAVRLQIRRGAKVIKVMASGGVMSRDDNPNFAQFSPEELKVI 231

Query: 227 GNIAKTRDLHIQSHISENRDEVEAVK-------NLYPSYKNYTSVYDKNNLLTNKTVMAH 279
              A  ++  + +H+      + A+K       ++  + +    +  +  +L   T    
Sbjct: 232 VEEAARQNRIVSAHVHGKAGIMAAIKAGCKSLEHVSYADEEVWELMKEKGILYVATRSVI 291

Query: 280 GCYLSAEELNVFHERGASIAHCPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSM 339
             +L++    +  E  A +    +S+L    G       +K  V I LGTD A G     
Sbjct: 292 EIFLASNGEGLVKESWAKLQALADSHLKAYQG------AIKAGVTIALGTDTAPGGP--- 342

Query: 340 LDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEI-GNFEVGKEFDAI 398
                     + + L   V    +T  E  + AT     ++G    + G    G E D I
Sbjct: 343 ----------TALELQFAVERGGMTPLEAIKAATANAPLSVGPQAPLTGQLREGYEADVI 392

Query: 399 LINPKASDSPIDLFYGDFFGDISEAVIQKFLYLGDDRNIEEVYVGGK 445
            +                     E  ++      + + +  V+ GGK
Sbjct: 393 ALE--------------------ENPLEDIKVFQEPKAVTHVWKGGK 419


>2QS8-A nrPDB
          Length = 418

 Score = 54.1 bits (128), Expect = 1e-07,   Method: Composition-based stats.
 Identities = 56/385 (14%), Positives = 110/385 (28%), Gaps = 68/385 (17%)

Query: 64  EIRELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEV 123
           +  +L  H    PGL+D H+H  Q  +   +     +E   +     +H +         
Sbjct: 52  DYIDLRDHTVL-PGLMDMHVHFGQ-EYQSKAQAPIKVEREMQAILATQHAYVTFKSGFTT 109

Query: 124 YTRVVRRTLKNGTTTACYFATIHTDSSLLLA--DITDKFGQR-AFVGKVCMDLNDTFPEY 180
             +V    L   +      +       +  A   I    G      GK   D +   PE 
Sbjct: 110 VRQVGDSGLVAISLRDAINSGKLAGPRIFAAGKTIATTGGHADPTNGKAVDDYDYPVPEQ 169

Query: 181 KETTEESIKETERFVSEMLQKNYSRVKPIVTPRF--------SLSCSETLMGELGNIAKT 232
                    E    V +  +     +K  VT           +   ++  +  + + AK 
Sbjct: 170 GVVNGPY--EVYAAVRQRYKDGADGIKITVTGGVLSVAKSGQNPQFTQEEVDAVVSAAKD 227

Query: 233 RDLHIQSHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFH 292
             + +  H        E +K    +  +                  HG ++  E +++  
Sbjct: 228 YGMWVAVHAH----GAEGMKRAIKAGVDSIE---------------HGTFMDLEAMDLMI 268

Query: 293 ERGASIAHCPNSNLSLS-----SGFLN-----------------VLEVLKHEVKIGLGTD 330
           E G       ++   ++       F                     +  +  VKI  GTD
Sbjct: 269 ENGTYYVPTISAGEFVAEKSKIDNFFPEIVRPKAASVGPQISDTFRKAYEKGVKIAFGTD 328

Query: 331 VAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFE 390
                  +        V            E  +   +  + AT+  ++ L ++ ++G+ E
Sbjct: 329 AGVQKHGTNWKEFVYMV------------ENGMPAMKAIQSATMETAKLLRIEDKLGSIE 376

Query: 391 VGKEFDAILINPKASDSPIDLFYGD 415
            GK  D I +     +    L   D
Sbjct: 377 SGKLADLIAVKGNPIEDISVLENVD 401


>2OGJ-A nrPDB
          Length = 417

 Score = 49.1 bits (115), Expect = 4e-06,   Method: Composition-based stats.
 Identities = 65/403 (16%), Positives = 124/403 (30%), Gaps = 90/403 (22%)

Query: 34  LGVSDSGKIVFLEEASQQEKLAKEWCFKPCEI-RELSHHEFFMPGLVDTHIHASQYSFAG 92
           + +   GKI  +  A Q           P +  R  +   F  PG VD H+H        
Sbjct: 38  ILIGGDGKIAAVGSALQA----------PADTQRIDAKGAFISPGWVDLHVH-------- 79

Query: 93  SSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTACYFATIHTDSSLL 152
                                  +I  +E    R V   +  G+     F         +
Sbjct: 80  ---------------IWHGGTDISIRPSECGAERGVTTLVDAGSAGEANFHGF---REYI 121

Query: 153 LADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESIKETERFVSEMLQKNYSRVKPIVTP 212
           +    ++      +G + +   +  PE ++  +    + +R +    + +   V   V  
Sbjct: 122 IEPSRERIKAFLNLGSIGLVACNRVPELRDIKD---IDLDRILECYAENSEHIVGLKVRA 178

Query: 213 RFSLSCS--ETLMGELGNIAKTRDLHIQSHISENRDEVEAVKNLYPSYKNYTSVYDK-NN 269
              ++ S   T +     IAK   + +  H+ E                   ++YD+   
Sbjct: 179 SHVITGSWGVTPVKLGKKIAKILKVPMMVHVGE-----------------PPALYDEVLE 221

Query: 270 LLTNKTVMAHGCY-------LSAEELNVFHERGASIAHCPNSNLSL------SSGFLNVL 316
           +L    V+ H          +  E+L    ER      C    + L      +S    V 
Sbjct: 222 ILGPGDVVTHCFNGKSGSSIMEDEDLFNLAER------CAGEGIRLDIGHGGASFSFKVA 275

Query: 317 EVLKHE--VKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATL 374
           E       +   + TD+  G+S +       A  +S +L ++      +  + V    T 
Sbjct: 276 EAAIARGLLPFSISTDLH-GHSMN-FPVWDLATTMSKLLSVD------MPFENVVEAVTR 327

Query: 375 GGSQALGLDGEIGNFEVGKEFDAILINPKASDSPIDLFYGDFF 417
             +  + LD E    +VG+  D  + +   +D       GD  
Sbjct: 328 NPASVIRLDME-NRLDVGQRADFTVFDLVDADLEATDSNGDVS 369


>3OOQ-A nrPDB
          Length = 396

 Score = 49.1 bits (115), Expect = 5e-06,   Method: Composition-based stats.
 Identities = 59/370 (15%), Positives = 118/370 (31%), Gaps = 46/370 (12%)

Query: 44  FLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWL 103
            L    + EK+ +       EI +L+  +F  PG VD H H   +   G           
Sbjct: 26  VLVSNGKVEKVGENIEDPDAEIVDLTG-KFLFPGFVDAHSHIGLFE-EGVGYYYSDGNEA 83

Query: 104 TKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTACYFATIHTDSSLLLADITDKFGQR 163
           T    P        +  +    R     L  G T+      I   S+  +         R
Sbjct: 84  TDPVTPHVKALDGFNPQDPAIERA----LAGGVTSVM----IVPGSANPVGGQGSVIKFR 135

Query: 164 AFVGKVCMDLNDTFPEYKETTEESIKETERFVSEMLQKNYSRVKPIVTPRFSLSCSETLM 223
           + + + C+      P   +      +  +R   E  Q   +R+      R   +  +  M
Sbjct: 136 SIIVEECI---VKDPAGLKMA--FGENPKRVYGERKQTPSTRMGTAGVIRDYFTKVKNYM 190

Query: 224 GELGNIAKTRD-----LHIQSHISENRDEVEAVKNLYPSYKN----YTSVYDKNNLLTNK 274
            +   +A+          ++  + E     +    ++    +       + ++       
Sbjct: 191 KK-KELAQKEGKEFTETDLKMEVGEMVLRKKIPARMHAHRADDILTAIRIAEEFGF---N 246

Query: 275 TVMAHGCYLSAEELNVFHERGASIAHCP----NSNLSLSSGFLN-VLEVLKHEVKIGLGT 329
            V+ HG         V  E+   +   P     + L L    +  + ++LK  V I L  
Sbjct: 247 LVIEHGTEAYKIS-KVLAEKKIPVVVGPLLTFRTKLELKDLTMETIAKLLKDGVLIALMC 305

Query: 330 DVAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNF 389
           D        ++      V  +  +      E       + ++ T+  ++ LGL+  IG+ 
Sbjct: 306 DHP------VIPLEFATVQAATAMRYGAKEED------LLKILTVNPAKILGLEDRIGSI 353

Query: 390 EVGKEFDAIL 399
           E GK+ D ++
Sbjct: 354 EPGKDADLVV 363


>1XRT-A nrPDB
          Length = 467

 Score = 48.3 bits (113), Expect = 7e-06,   Method: Composition-based stats.
 Identities = 62/423 (14%), Positives = 123/423 (29%), Gaps = 95/423 (22%)

Query: 23  TCPMEVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTH 82
             P + L      + ++GKI  +           +    P      +      PG +D H
Sbjct: 57  IDPSQNLEGEFDILVENGKIKKI----------DKNILVPEAEIIDAKGLIVCPGFIDIH 106

Query: 83  IHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTACYF 142
           +H                        P +   ++I+             +  G TT    
Sbjct: 107 VHL---------------------RDPGQTYKEDIESGSRCA-------VAGGFTTIVCM 138

Query: 143 ATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESIKETERFVSEMLQKN 202
              +                ++      +            T    ++ +        K 
Sbjct: 139 PNTNPPIDNTTVVNYILQKSKSVGLCRVL---------PTGTITKGRKGKEIADFYSLKE 189

Query: 203 YSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISE--------NRDEVEAVKNL 254
              V    T   S     ++M +   +A    + I  H  +        N  EV A+  L
Sbjct: 190 AGCV--AFTDDGSPVMDSSVMRKALELASQLGVPIMDHCEDDKLAYGVINEGEVSALLGL 247

Query: 255 YPSYKNYTSV-YDKNNLLTNKTV-MAHGCYLSA----EELNVFHERGASIAHCPNSNLSL 308
                    +   ++ +L  +T    H  ++S     E +  F E+G  I    N N  L
Sbjct: 248 SSRAPEAEEIQIARDGILAQRTGGHVHIQHVSTKLSLEIIEFFKEKGVKITCEVNPNHLL 307

Query: 309 -------SSGF-----LNVLEVLKH-----EVKIGL----GTDVAGGYSYSMLDAIRRAV 347
                  +SG        + +          VK G+     TD A   ++     +    
Sbjct: 308 FTEREVLNSGANARVNPPLRKKEDRLALIEGVKRGIIDCFATDHAPHQTFE--KELVEFA 365

Query: 348 MVSNILLINKVN-------EKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILI 400
           M   I L   +        +  ++LK++  + T+  ++ +G+D  +G  ++G   D  + 
Sbjct: 366 MPGIIGLQTALPSALELYRKGIISLKKLIEMFTINPARIIGVD--LGTLKLGSPADITIF 423

Query: 401 NPK 403
           +P 
Sbjct: 424 DPN 426


>1YRR-A nrPDB
          Length = 382

 Score = 44.1 bits (102), Expect = 1e-04,   Method: Composition-based stats.
 Identities = 62/401 (15%), Positives = 120/401 (29%), Gaps = 72/401 (17%)

Query: 27  EVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHAS 86
           E L DH + ++D G I  +   ++             E R L+      PG +D      
Sbjct: 14  EFLDDHAVVIAD-GLIKSVCPVAEL--------PPEIEQRSLNG-AILSPGFIDVQ---- 59

Query: 87  QYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTACYFATIH 146
                G                    +F +   A  V T  + +     +    Y  T+ 
Sbjct: 60  ---LNGCGG----------------VQFNDTAEAVSVETLEIMQKANEKSGCTNYLPTL- 99

Query: 147 TDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEYKETT-----------EESIKETERFV 195
               +  +D   K G R     +    N     + E                +++ +  +
Sbjct: 100 ----ITTSDELMKQGVRVMREYLAKHPNQALGLHLEGPWLNLVKKGTHNPNFVRKPDAAL 155

Query: 196 SEMLQKNYSRV-KPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKNL 254
            + L +N   + K  + P    +   + +   G +      +     ++           
Sbjct: 156 VDFLCENADVITKVTLAPEMVPAEVISKLANAGIVVSAGHSNATLKEAKAGFRAGITFAT 215

Query: 255 YPSYKNYTSVYDKNNLLTNKT--------VMAHGCYLSAEELNVFHERGASIAHCPNSNL 306
           +           +  L             ++A G ++    +    +R      C  ++ 
Sbjct: 216 HLYNAMPYITGREPGLAGAILDEADIYCGIIADGLHVDYANIRN-AKRLKGDKLCLVTDA 274

Query: 307 SLSSGFLNVLEVLKHEVKI----GLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNEKS 362
           +  +G  N+ + +     I    GL  D  G  S S L  I            N V    
Sbjct: 275 TAPAG-ANIEQFIFAGKTIYYRNGLCVDENGTLSGSSLTMIEGVR--------NLVEHCG 325

Query: 363 LTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPK 403
           + L EV R+ATL  ++A+G++  +G    GK  +     P 
Sbjct: 326 IALDEVLRMATLYPARAIGVEKRLGTLAAGKVANLTAFTPD 366


>1NFG-A nrPDB
          Length = 457

 Score = 44.1 bits (102), Expect = 1e-04,   Method: Composition-based stats.
 Identities = 67/423 (15%), Positives = 130/423 (30%), Gaps = 64/423 (15%)

Query: 17  FVHSTWTCPMEVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMP 76
            + +      + +    LG+ D GKI  +  A             P E    +   +  P
Sbjct: 4   IIKNGTIVTADGISRADLGIKD-GKITQIGGA-----------LGPAERTIDAAGRYVFP 51

Query: 77  GLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVR----RTL 132
           G +D H H    SF   S D      +            +    +  ++          +
Sbjct: 52  GGIDVHTHVETVSFNTQSADTFATATVAAACG-GTTTIVDFCQQDRGHSLAEAVAKWDGM 110

Query: 133 KNGTTTACYFATI----HTDSSLLLADITDKFGQ---RAFVGKVCMDLNDTFPEYKETTE 185
             G +   Y   I     TDS +   ++    G    + F+    M++ D      +T +
Sbjct: 111 AGGKSAIDYGYHIIVLDPTDSVIEELEVLPDLGITSFKVFMAYRGMNMIDDV-TLLKTLD 169

Query: 186 ESIKETERFVSEMLQKN---YSRVKPIVTPRF---------SLSCSETLMGELGNIAKTR 233
           +++K     +      +   Y R K +   +                        +A+  
Sbjct: 170 KAVKTGSLVMVHAENGDAADYLRDKFVAEGKTAPIYHALSRPPRVEAEATARALALAEIV 229

Query: 234 DLHIQS-HIS--ENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNV 290
           +  I   H++  E+ +EV   K+             +           H  YL+ E+L  
Sbjct: 230 NAPIYIVHVTCEESLEEVMRAKS------RGVRALAE--------TCTHYLYLTKEDLER 275

Query: 291 FHERGASIAHCPNSNLS---------LSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLD 341
               GA     P +            L +G    +    H   +  G    G   +  + 
Sbjct: 276 PDFEGAKYVFTPPARAKKDHDVLWNALRNGVFETVS-SDHCSWLFKGHKDRGRNDFRAIP 334

Query: 342 AIRRAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILIN 401
                V    +++   VNE  ++L +   L     ++  G+  + G   VG + D +L +
Sbjct: 335 NGAPGVEERLMMVYQGVNEGRISLTQFVELVATRPAKVFGMFPQKGTIAVGSDADIVLWD 394

Query: 402 PKA 404
           P+A
Sbjct: 395 PEA 397


>6NBO-A nrPDB
          Length = 402

 Score = 43.3 bits (100), Expect = 2e-04,   Method: Composition-based stats.
 Identities = 56/401 (13%), Positives = 109/401 (27%), Gaps = 49/401 (12%)

Query: 45  LEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLT 104
           L E  +  +        P    E       +PGLV+ H H  +  +         + W  
Sbjct: 28  LIEGDRIARTGPSLDAPPGCAIEEGAGAIALPGLVEGHTHLDKTHWG--------MPWYR 79

Query: 105 KYTFP---------AEHRFQNIDFAEEVYTRVVRRTLKNGTTTACYFATIHTDSSLLLAD 155
               P           +R  +   A      + R  L  GTT       +  D+   L  
Sbjct: 80  NAVGPRLVDRIENERHYRATSGHDAGAASLALARAFLAAGTTRIRTHVDV--DTDAGLRH 137

Query: 156 ITDKFGQRAFVGKVCMDLNDTFPEYKETTEESIKETERFVSEMLQKNYSRVKPIVTPRFS 215
           +      R  +          FP+         +     +        + +   + P   
Sbjct: 138 LHRVLDTRETLRGQVEIQIVAFPQSG----VLKRPGTDALLADALAAGADLLGGLDPCAI 193

Query: 216 LSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKT 275
                  +  L  IA+     +  H+ E         +L                + +K 
Sbjct: 194 EGDPVKAVDVLFGIAERYGRGLDLHLHERGSMGAYSLDLI------LQRTAALG-MQHKV 246

Query: 276 VMAHGCYLS-------AEELNVFHERGASIAHCPNSNLSLSSGFLNVLEVLKHEVKIGLG 328
            ++H   L           L    E G ++     + + + S    VL      V +  G
Sbjct: 247 TISHAFCLGDLAERERDALLARMAELGVAVVTTAPAAVPVPS----VLACRAAGVTVIGG 302

Query: 329 TDVAGG--YSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEI 386
            D        Y   D + RA++++      + +     L+      T G ++  G D   
Sbjct: 303 NDGVRDTWTPYGSPDMLERAMLIAMRNDFRRDDA----LEVALECVTHGAARGCGFDAY- 357

Query: 387 GNFEVGKEFDAILINPKASDSPIDLFYGDFFGDISEAVIQK 427
              + G   D +L++       +           S  ++ +
Sbjct: 358 -GLQPGARADVVLVDAMTLAEAVVARPVRRLVVSSGKIVAR 397


>6AJD-A nrPDB
          Length = 485

 Score = 43.3 bits (100), Expect = 2e-04,   Method: Composition-based stats.
 Identities = 66/416 (15%), Positives = 113/416 (27%), Gaps = 52/416 (12%)

Query: 60  FKPCEIRELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQN-ID 118
              C++ +    ++ MPG +D H H  Q  F G+                      + + 
Sbjct: 38  PSGCDVLD-GGGQYLMPGGIDPHTHM-QLPFMGTVASEDFFSGTAAGLAGGTTSIIDFVI 95

Query: 119 FAEEVYTRVVRRTLKNGTTTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFP 178
                       T +     +      H   +    ++  + G    V +  ++    F 
Sbjct: 96  PNPRQSLLEAFHTWRGWAQKSAADYGFHVAITWWSDEVAREMG--ELVAQHGVNSFKHFM 153

Query: 179 EYKE----TTEESIKETER------------------FVSEMLQKNYSRVKPIVTPRF-S 215
            YK       +  +   ER                  F  +          P   P    
Sbjct: 154 AYKNAIMAADDTLVASFERCLELGAVPTVHAENGELVFHLQQKLLAQGLTGPEAHPLSRP 213

Query: 216 LSCSETLMGELGNIAKTRDLHIQ-SHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNK 274
                        IA+T    +   HIS      E           Y  V   + LL + 
Sbjct: 214 PQVEGEAASRAIRIAETLGTPLYLVHISSREALDEIAYARAKGQPVYGEVLAGH-LLLDD 272

Query: 275 TVMAHGCYLSAEELNVFHERGASIAHCPNSNLSLSSGFLNVLEVLKH----EVKIGLGTD 330
           +V  H  + +A    V       + H       L SG L+      H      +  +G D
Sbjct: 273 SVYRHPDWATAAGY-VMSPPFRPVEHQEALWRGLQSGNLHTTA-TDHCCFCAEQKAMGRD 330

Query: 331 VAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFE 390
                         R  +    L    VN   L++ E   L +   ++   L    G   
Sbjct: 331 DFSKIPNGTAGIEDRMAL----LWDAGVNSGRLSMHEFVALTSTNTAKIFNLFPRKGAIR 386

Query: 391 VGKEFDAILINPKASDSP----------IDLFYGDFFGDISEAVIQK--FLYLGDD 434
           VG + D +L +P+ S +            ++F G     I    I +   L+   D
Sbjct: 387 VGADADLVLWDPQGSRTLSAATHHQRVDFNIFEGRTVRGIPSHTISQGKLLWAAGD 442


>3EWD-A nrPDB
          Length = 370

 Score = 43.3 bits (100), Expect = 2e-04,   Method: Composition-based stats.
 Identities = 20/142 (14%), Positives = 49/142 (34%), Gaps = 18/142 (12%)

Query: 213 RFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLT 272
                       E+ +  +   + +  H  E+   +  +  LY + +      ++     
Sbjct: 198 HGGHEVDLKEYKEIFDYVRESGVPLSVHAGEDVT-LPNLNTLYSAIQ--VLKVERIG--- 251

Query: 273 NKTVMAHGCYL--SAEELNVFHERGASIAHCPNSNLSLSSG----FLNVLEVLKHEVKIG 326
                 HG  +  S E +++  E+   +  CP SN+ L +        + ++    VK+ 
Sbjct: 252 ------HGIRVAESQELIDMVKEKNILLEVCPISNVLLKNAKSMDTHPIRQLYDAGVKVS 305

Query: 327 LGTDVAGGYSYSMLDAIRRAVM 348
           + +D  G +  ++ D       
Sbjct: 306 VNSDDPGMFLTNINDDYEELYT 327


>6II7-A nrPDB
          Length = 367

 Score = 42.1 bits (97), Expect = 4e-04,   Method: Composition-based stats.
 Identities = 25/142 (17%), Positives = 51/142 (35%), Gaps = 18/142 (12%)

Query: 213 RFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLT 272
                       ++ +  +   + I  H  E+            S  N  S+Y   NLL 
Sbjct: 203 HAGHEVDLKPFKDIFDNIREEGISISVHAGEDV-----------SIPNLNSLYTAINLLH 251

Query: 273 NKTVMAHGCYLSAEE--LNVFHERGASIAHCPNSNLSLSS----GFLNVLEVLKHEVKIG 326
            K +  HG  +S  +  +++  E+   +  CP SN+ L++        +  +    VK+ 
Sbjct: 252 VKRI-GHGIRVSESQELIDLVKEKDILLEVCPISNVLLNNVKSMDTHPIRMLYDAGVKVS 310

Query: 327 LGTDVAGGYSYSMLDAIRRAVM 348
           + +D  G +  ++ D       
Sbjct: 311 VNSDDPGMFLTNITDNYEELYT 332


>2AMX-A nrPDB
          Length = 376

 Score = 41.4 bits (95), Expect = 9e-04,   Method: Composition-based stats.
 Identities = 21/109 (19%), Positives = 44/109 (40%), Gaps = 18/109 (16%)

Query: 231 KTRDLHIQSHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEE--L 288
           +   LH+  H  E+               N  ++Y   N+L  + +  HG  +S  +  +
Sbjct: 230 RDHGLHLTVHAGEDAT-----------LPNLNTLYTAINILNVERI-GHGIRVSESDELI 277

Query: 289 NVFHERGASIAHCPNSNLSLSS----GFLNVLEVLKHEVKIGLGTDVAG 333
            +  ++   +  CP SNL L++        + ++    VK+ + +D  G
Sbjct: 278 ELVKKKDILLEVCPISNLLLNNVKSMDTHPIRKLYDAGVKVSVNSDDPG 326


>2VUN-A nrPDB
          Length = 386

 Score = 41.0 bits (94), Expect = 0.001,   Method: Composition-based stats.
 Identities = 56/397 (14%), Positives = 101/397 (25%), Gaps = 65/397 (16%)

Query: 28  VLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQ 87
           VL+   + V D G I  +      +                +      PGL+DTH+H S 
Sbjct: 21  VLQADTIVVED-GLIAAIGGEELMKDAGDA-------TIIDAAGSTVTPGLLDTHVHVS- 71

Query: 88  YSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTR-VVRRTLKNGTTTACYFATIH 146
                                         D+A    T   +   L  G TT     + H
Sbjct: 72  ----------------------------GGDYAPRQKTMDFISSALHGGVTTMISAGSPH 103

Query: 147 TDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESIKETERFVSE-MLQKNYSR 205
                      D  G +A    +     +  P   +    ++   +    E  ++     
Sbjct: 104 FPG-----RPKDAAGTKALAITLSKSYYNARPAGVKVHGGAVILEKGLTEEDFIEMKKEG 158

Query: 206 VKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKNLYPSYKNYTSVY 265
           V  +         +      +   A      +Q H         +        K    V 
Sbjct: 159 VWIVGEVGLGTIKNPEDAAPMVEWAHKHGFKVQMHTGGTSIPGSSTVTADDVIKTKPDVV 218

Query: 266 DKNNLLTNKTVMAHGCY--LSAEELNVFHERGASIAHCPNSNLSLSSGFLNVLEVLKHEV 323
              N      +        +   +  +       I  C   N  ++              
Sbjct: 219 SHIN-GGPTAISVQEVDRIMDETDFAM------EIVQC--GNPKIADYVARRAAEKGQLG 269

Query: 324 KIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLD 383
           ++  G D   G     L  +R    ++++          +  +    +AT   +   GL+
Sbjct: 270 RVIFGNDAPSGTGLIPLGILRNMCQIASM--------SDIDPEVAVCMATGNSTAVYGLN 321

Query: 384 GEIGNFEVGKEFDAILINPKASDSPIDLFYGDFFGDI 420
              G    GKE D I+++        D       GDI
Sbjct: 322 --TGVIAPGKEADLIIMDTPLGSVAEDAMGAIAAGDI 356


>3E74-A nrPDB
          Length = 473

 Score = 41.0 bits (94), Expect = 0.001,   Method: Composition-based stats.
 Identities = 54/424 (12%), Positives = 126/424 (29%), Gaps = 67/424 (15%)

Query: 28  VLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQ 87
           ++++  + + +  ++V +     +     +      E+ + S      PG+VD H H S+
Sbjct: 26  IIKNGTVILENEARVVDIAVKGGKIAAIGQDLGDAKEVMDASG-LVVSPGMVDAHTHISE 84

Query: 88  ------------YSFAGSSIDLPLLEW-LTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKN 134
                          A       ++E  L +     +     + F        +      
Sbjct: 85  PGRSHWEGYETGTRAAAKGGITTMIEMPLNQLPATVDRASIELKFDAAKGKLTIDAAQLG 144

Query: 135 GTTTACYFATIHTDSSLLLADITDKFGQRAFVG-KVCMDLNDTFPEYKE----------- 182
           G  +         D    L ++    G + FV       +++ F +  +           
Sbjct: 145 GLVSYNI------DRLHELDEV-GVVGFKCFVATCGDRGIDNDFRDVNDWQFFKGAQKLG 197

Query: 183 --TTEESIKETERFVSEMLQKNYSRVKPIVTPRFSLSCSE-----TLMGELGNIAKTRDL 235
                  +      + + L +   R +  VT    ++          +  +  +AK    
Sbjct: 198 ELGQPVLVHCENALICDELGEEAKR-EGRVTAHDYVASRPVFTEVEAIRRVLYLAKVAGC 256

Query: 236 HIQ-SHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHER 294
            +   H+S + + VE V       ++ T     +  + +            EE+    + 
Sbjct: 257 RLHVCHVS-SPEGVEEVTRARQEGQDITCESCPHYFVLDTDQF--------EEIGTLAK- 306

Query: 295 GASIAHCPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVA-------GGYSYSMLDAIRRAV 347
                 C      L +      ++   E+   L +D +        G        I    
Sbjct: 307 ------CSPPIRDLENQKGMWEKLFNGEIDC-LVSDHSPCPPEMKAGNIMKAWGGIAGLQ 359

Query: 348 MVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDS 407
              +++    V ++ ++L    +L     +   GL  + G    GK+ D + I P +S  
Sbjct: 360 SCMDVMFDEAVQKRGMSLPMFGKLMATNAADIFGLQQK-GRIAPGKDADFVFIQPNSSYV 418

Query: 408 PIDL 411
             + 
Sbjct: 419 LTND 422


>1YNY-A nrPDB
          Length = 461

 Score = 38.7 bits (88), Expect = 0.005,   Method: Composition-based stats.
 Identities = 56/386 (14%), Positives = 112/386 (29%), Gaps = 94/386 (24%)

Query: 74  FMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLK 133
            +PG +D H H                                     + +    R    
Sbjct: 50  VIPGGIDPHTHLDM--------------------------PFGGTVTADDFFTGTRAAAF 83

Query: 134 NGTTTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESIKETER 193
            GTT+   F       SL  A  T     R   GK  +D         E  ++ ++E E 
Sbjct: 84  GGTTSIVDFCLTKKGESLKSAIATWHEKAR---GKAVIDYGFHL-MIAEANDQVLEELES 139

Query: 194 FVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKN 253
            +S    +  + +K  +  +      +  + +    AK     +Q H +EN D ++ +  
Sbjct: 140 VISS---EGITSLKVFMAYKNVFQADDETLFKTLVKAKELGALVQVH-AENGDVLDYLTK 195

Query: 254 ----------LYPSYKNYTSVYDK--------NNLLTNKTVMAHGCYLSAEELNVFHER- 294
                     +Y +Y        +          L  ++  + H    SA  +    E  
Sbjct: 196 KALAEGNTDPIYHAYTRPPEAEGEATGRAIALTALAGSQLYVVHVSCASA--VQRIAEAR 253

Query: 295 ----GASIAHCPNSNLSLSSGFLNVLEV-----------------------LKHEVKIGL 327
                     CP   L+L    ++  +                        LK+ +   +
Sbjct: 254 EKGWNVYGETCPQY-LALDVSIMDQPDFEGAKYVWSPPLREKWNQEVLWSALKNGILQTV 312

Query: 328 GTD-----------VAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATLGG 376
           G+D           +  G    + +          IL    V +  ++L +   +++   
Sbjct: 313 GSDHCPFNFRGQKELGRGDFTKIPNGGPLIEDRLTILYSEGVRQGRISLNQFVDISSTKA 372

Query: 377 SQALGLDGEIGNFEVGKEFDAILINP 402
           ++  G+    G   VG + D ++ +P
Sbjct: 373 AKLFGMFPRKGTIAVGSDADIVIFDP 398


>3IV8-A nrPDB
          Length = 381

 Score = 38.7 bits (88), Expect = 0.006,   Method: Composition-based stats.
 Identities = 18/73 (24%), Positives = 30/73 (41%), Gaps = 8/73 (10%)

Query: 329 TDVAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGN 388
            D  G    S L  I            N V    + L E  R+ATL  ++A+G+D ++G 
Sbjct: 300 VDENGTLGGSALTMIEAV--------QNTVEHVGIALDEALRMATLYPAKAIGVDEKLGR 351

Query: 389 FEVGKEFDAILIN 401
            + G   +  + +
Sbjct: 352 IKKGMIANLTVFD 364


>1GKQ-A nrPDB
          Length = 458

 Score = 37.5 bits (85), Expect = 0.012,   Method: Composition-based stats.
 Identities = 35/222 (15%), Positives = 71/222 (31%), Gaps = 36/222 (16%)

Query: 46  EEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTK 105
            E     ++ +     P      +  ++  PG +D H+H            LP +     
Sbjct: 22  AEGETITRIGQNLEAPPGTEVIDATGKYVFPGFIDPHVHIY----------LPFMA---- 67

Query: 106 YTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTACYFATIHTDSSLLLADITDKFGQRAF 165
                        FA++ +    +  L  GTTT      I         D  + +     
Sbjct: 68  ------------TFAKDTHETGSKAALMGGTTT-----YIEMCCPSRNDDALEGYQLWKS 110

Query: 166 VGKVCMDLNDTFPEYKETTEESIKETERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGE 225
             +     + TF       +E   +TE  + E++    S  K  ++ +      +  M +
Sbjct: 111 KAEGNSYCDYTFHMAVSKFDE---KTEGQLREIVADGISSFKIFLSYKNFFGVDDGEMYQ 167

Query: 226 LGNIAKTRDLHIQSHISENRDEVEAV-KNLYPSYKNYTSVYD 266
              +AK   + + +H  EN + V  + + L    K     ++
Sbjct: 168 TLRLAKELGVIVTAHC-ENAELVGRLQQKLLSEGKTGPEWHE 208



 Score = 37.1 bits (84), Expect = 0.015,   Method: Composition-based stats.
 Identities = 12/53 (22%), Positives = 23/53 (43%)

Query: 351 NILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPK 403
           N+L    V+   L +      A+   ++  GL    G   VG + D ++ +P+
Sbjct: 345 NLLYTYGVSRGRLDIHRFVDAASTKAAKLFGLFPRKGTIAVGSDADLVVYDPQ 397


>3T8L-A nrPDB
          Length = 608

 Score = 36.4 bits (82), Expect = 0.025,   Method: Composition-based stats.
 Identities = 32/180 (17%), Positives = 60/180 (33%), Gaps = 35/180 (19%)

Query: 269 NLLTNKTVMAHGCYLSAEELNVFHERGASIAHCPNSNLSLSSGFLNVLEVLKHEVKIGLG 328
            L   K V  H   L   +LN F   G S      S+  L SG     E L  +++ GL 
Sbjct: 211 GLAAEKLVCGHARGLKNADLNAFMAAGVS------SDHELVSG-----EDLMAKLRAGLT 259

Query: 329 TDVAGGYS---------YSMLDAI-RRAVMVSNILLINKVNEKS-------------LTL 365
            ++ G +           + L  + +   + ++ +  + + +               L  
Sbjct: 260 IELRGSHDHLLPEFVAALNTLGHLPQTVTLCTDDVFPDDLLQGGGLDDVVRRLVRYGLKP 319

Query: 366 KEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDSPIDLFYGDFFGDISEAVI 425
           +   R ATL  +Q LG   ++G    G+  D ++       S   +            ++
Sbjct: 320 EWALRAATLNAAQRLGR-SDLGLIAAGRRADIVVFEDLNGFSARHVLASGRAVAEGGRML 378


>4CEX-C nrPDB
          Length = 570

 Score = 36.4 bits (82), Expect = 0.029,   Method: Composition-based stats.
 Identities = 16/52 (30%), Positives = 23/52 (44%)

Query: 352 ILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPK 403
            L   K    +  LK      T+  + A G+  E+G+ E GK  D +L  PK
Sbjct: 390 PLAEEKNGSDNFRLKRYVSKYTINPAIAQGIAHEVGSIEEGKFADLVLWEPK 441


>2VHL-A nrPDB
          Length = 396

 Score = 36.4 bits (82), Expect = 0.030,   Method: Composition-based stats.
 Identities = 58/409 (14%), Positives = 128/409 (31%), Gaps = 89/409 (21%)

Query: 27  EVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHAS 86
           EV+++  +G++D GKI  +     +E  +KE    P +          +PG++D HIH  
Sbjct: 17  EVIKNGYVGIND-GKISTVSTERPKEPYSKE-IQAPAD-------SVLLPGMIDIHIHG- 66

Query: 87  QYSFAGSSIDLPLLEW-LTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTACYFATI 145
              +   ++D       +     P E                   T ++G  +      +
Sbjct: 67  --GYGADTMDASFSTLDIMSSRLPEEGT---------TSFLATTITQEHGNISQA----L 111

Query: 146 HTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPE---YKETTEESIKETE-RFVSEMLQK 201
                   A+ +   G       + + L   F          +E I+ ++     +  Q+
Sbjct: 112 VNAREWKAAEESSLLG----AELLGIHLEGPFVSPKRAGAQPKEWIRPSDVELFKKWQQE 167

Query: 202 NYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKNLYPSYKNY 261
               +K +       + +         I   +D  I + +     +   + +   +    
Sbjct: 168 AGGLIKIV-------TLAPEEDQHFELIRHLKDESIIASMGHTDADSALLSDAAKAG--- 217

Query: 262 TSVYDKNNLLTNKTVMAHGCYLSAEELNVFHE----RGASIAHCPNSNLSLSSGF----- 312
                           +H  +L        H      G ++AH       ++ G      
Sbjct: 218 ---------------ASHMTHLYNAMSPFHHREPGVIGTALAHDGFVTELIADGIHSHPL 262

Query: 313 -LNVLEVLKHEVKIGLGTDVAGGYSY---------SMLDAIRRAVMVSNILLINKV---N 359
              +  + K   K+ L TD                  +    R  ++S+  L   +   N
Sbjct: 263 AAKLAFLAKGSSKLILITDSMRAKGLKDGVYEFGGQSVTVRGRTALLSDGTLAGSILKMN 322

Query: 360 EKSLTLKE--------VFRLATLGGSQALGLDGEIGNFEVGKEFDAILI 400
           E +  ++E        +  + +   ++ LG+    G+  VGK+ D +++
Sbjct: 323 EGARHMREFTNCSWTDIANITSENAAKQLGIFDRKGSVTVGKDADLVIV 371


>5NKS-A nrPDB
          Length = 573

 Score = 36.0 bits (81), Expect = 0.036,   Method: Composition-based stats.
 Identities = 43/266 (16%), Positives = 81/266 (30%), Gaps = 51/266 (19%)

Query: 67  ELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTR 126
             +H    +PG VD H                          PA+            + +
Sbjct: 59  IDAHGLMVLPGGVDVHTRLQMPVLG---------------MTPADD-----------FCQ 92

Query: 127 VVRRTLKNGTTTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEYKETTEE 186
             +  L  GTT       +  D+ + L    +++ +RA     C      +  + + T  
Sbjct: 93  GTKAALAGGTTMILDH--VFPDTGVSLLAAYEQWRERADSAACC-----DYSLHVDITRW 145

Query: 187 SIKETERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRD 246
                E   + + +K  +     +  +    CS++ M E+ +I +      Q H +EN D
Sbjct: 146 HESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQMYEIFSIIRDLGALAQVH-AENGD 204

Query: 247 EVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASI---AHCPN 303
            VE  +              +  +   +    H      E       R  +I   A+CP 
Sbjct: 205 IVEEEQK----------RLLELGITGPE---GHVLSHPEEVEAEAVYRAVTIAKQANCPL 251

Query: 304 SNLS-LSSGFLNVLEVLKHEVKIGLG 328
                +S G  + +   K    +  G
Sbjct: 252 YVTKVMSKGAADAIAQAKRRGVVVFG 277


>3IGH-X nrPDB
          Length = 486

 Score = 36.0 bits (81), Expect = 0.040,   Method: Composition-based stats.
 Identities = 10/44 (22%), Positives = 23/44 (52%), Gaps = 1/44 (2%)

Query: 358 VNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILIN 401
             +++L +K+     T G ++   L  +IG  E G + + I+++
Sbjct: 429 TKDQALDIKDALHSYTYGSARV-SLASDIGKLEPGFKAEYIILD 471



 Score = 32.5 bits (72), Expect = 0.41,   Method: Composition-based stats.
 Identities = 39/285 (13%), Positives = 87/285 (30%), Gaps = 23/285 (8%)

Query: 17  FVHSTWTCPMEVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMP 76
            ++ T       L+     V   GK+++  ++   +K+ +       EI +L   ++ MP
Sbjct: 6   LINGTIYTSFNPLKKVSGLVISHGKVIYAGDSEVAKKIVELSGG---EIVDLKG-KYVMP 61

Query: 77  GLVDTHIH-------ASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVR 129
              D+H+H              G+     L++ L +        F   D  E       +
Sbjct: 62  AFFDSHLHLDELGMSLEMVDLRGAKSIEELIQRLKRGKGRIIFGF-GWDQDELGEWPTRK 120

Query: 130 RTLKNGTTTACYFATIHTDSSLLLADITDKFGQ---RAFVGKVCMDLNDTFPEYKETTEE 186
               N      +        ++    + +       + F     +    +  E ++   E
Sbjct: 121 EL--NAIDKPVFIYRKCFHVAVANDKMLELLNLTPSKDFDEDTGIIKEKSLEEARKVINE 178

Query: 187 SIKETERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHIS---E 243
            +   E +V  + +     +   V     +S +E  +  L  + +   L I        E
Sbjct: 179 RVLTVEDYVYYIKRAQEHLLDLGVKSVSFMSVNEKALRALFYLEREGKLSINVFAYVTPE 238

Query: 244 NRDEVEAVKNLYPSYKNYT---SVYDKNNLLTNKTVMAHGCYLSA 285
             D++E++          T        +  L  +T +    Y   
Sbjct: 239 VLDKLESIGLGRFQGNRLTIAGVKLFTDGSLGARTALLSKPYSDD 283


>4Z42-C nrPDB
          Length = 572

 Score = 35.2 bits (79), Expect = 0.068,   Method: Composition-based stats.
 Identities = 12/31 (38%), Positives = 19/31 (61%)

Query: 373 TLGGSQALGLDGEIGNFEVGKEFDAILINPK 403
           T+  + A G+   IG+ EVGK  D +L +P+
Sbjct: 413 TINPAIAQGVSHVIGSVEVGKMADLVLWDPR 443


>3MPG-A nrPDB
          Length = 428

 Score = 34.4 bits (77), Expect = 0.097,   Method: Composition-based stats.
 Identities = 69/424 (16%), Positives = 129/424 (30%), Gaps = 96/424 (22%)

Query: 35  GVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSH--HEFFMPGLVDTHIHASQYSFAG 92
            +++ GKIV  +   Q  K+AK       +  E+     +   PGLVD H+H  +     
Sbjct: 10  YMNEEGKIVATDLLVQDGKIAKVAENITADNAEVIDVNGKLIAPGLVDVHVHLREPG--- 66

Query: 93  SSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTACYFATI--HTDSS 150
                             EH+        E          K G TT C         D  
Sbjct: 67  -----------------GEHK--------ETIETGTLAAAKGGFTTICAMPNTRPVPDCR 101

Query: 151 LLLADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESIKETERFVSEMLQKNYSRVKPIV 210
             + D+ ++  ++A V        +  P    T  ++  E   F +      ++     V
Sbjct: 102 EHMEDLQNRIKEKAHV--------NVLPYGAITVRQAGSEMTDFETLKELGAFAFTDDGV 153

Query: 211 TPRFSLSCSETLMGELGNIAKTRDLHIQSH-----------ISENRDEVEAVKNLYPSYK 259
             + +     ++M      A   ++ + +H           + E +   +   N  PS  
Sbjct: 154 GVQDA-----SMMLAAMKRAAKLNMAVVAHCEENTLINKGCVHEGKFSEKHGLNGIPSVC 208

Query: 260 NYTSVYDKNNLLTNKTVMAHGCYLSAEE----LNVFHERGASI---------AHC----- 301
               +     L        H C++S +     +      G  +           C     
Sbjct: 209 ESVHIARDILLAEAADCHYHVCHVSTKGSVRVIRDAKRAGIKVTAEVTPHHLVLCEDDIP 268

Query: 302 -PNSNLSLSSGFLNVLEVLKHEVKIG---------LGTDVAGGYSYSMLDAIRRA----- 346
             + N  ++     +     HE  I          + TD A   +      I RA     
Sbjct: 269 SADPNFKMNP---PLRGKEDHEALIEGLLDGTIDMIATDHAPHTAEEKAQGIERAPFGIT 325

Query: 347 --VMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKA 404
                  +L  N V +  +TL+++ +  T   +   GL  E G  + G+  D  +I+ + 
Sbjct: 326 GFETAFPLLYTNLVKKGIITLEQLIQFLTEKPADTFGL--EAGRLKEGRTADITIIDLEQ 383

Query: 405 SDSP 408
            +  
Sbjct: 384 EEEI 387


>1RK6-A nrPDB
          Length = 496

 Score = 34.4 bits (77), Expect = 0.12,   Method: Composition-based stats.
 Identities = 8/52 (15%), Positives = 16/52 (30%)

Query: 40 GKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQYSFA 91
          G++  +     +     +        R     +   PG +D+H H   Y   
Sbjct: 38 GRLADVGVRGDRIAAVGDLSASSARRRIDVAGKVVSPGFIDSHTHDDNYLLK 89


>5XGX-A nrPDB
          Length = 395

 Score = 34.1 bits (76), Expect = 0.14,   Method: Composition-based stats.
 Identities = 62/410 (15%), Positives = 124/410 (30%), Gaps = 80/410 (19%)

Query: 23  TCPMEVLRDHLLGVSD----SGKIVFLEEASQQE-KLAKEWCFKPCEIRELSHHEFFMPG 77
            C + +   + LG+ D      KI  + +  Q E  + K+W  K              PG
Sbjct: 11  LCNVNIYAPNPLGIKDVLIAGNKIAAIYDHGQGEITIPKQWPVKVINF----DGAILTPG 66

Query: 78  LVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTT 137
            +D+H H       G +                        FA +V    +      G T
Sbjct: 67  FIDSHAHI--TGGGGQAG-----------------------FATQVPPVGLTEFTHAGVT 101

Query: 138 TACYFATIHTDSSLLLADITDKF------GQRAFVGKVCMDL-NDTFPEYKETTEESIKE 190
           T         D++    ++  +       G  A+           T     ++    ++ 
Sbjct: 102 TVVGLLG-TDDTTRSTENLLSRVYGLREEGLSAYCWTGGYHFPLTTITGSAKSDIAFLEP 160

Query: 191 T---ERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDE 247
                 F     + +    + ++        +  + G+ G         I  H+ +    
Sbjct: 161 VIGIGEFAISDHRSSQPTFEEVIRLASETHVAGLITGKAGV--------IHFHLGDGERR 212

Query: 248 VEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAHC--PNSN 305
           +E ++      +    V++  ++  NK +         E+      +G  I     P   
Sbjct: 213 LELIERAIRETELPARVFNPTHVNRNKPLF--------EDSCKLLSKGCHIDLTAFPAGT 264

Query: 306 LSLSSGFLNVLEVL-KHEVK---IGLGTDVAG--------GYSYSMLDAIRRAVMVSNIL 353
                   + +E+  + ++    I L +D  G        G    M     RA  +   L
Sbjct: 265 AQPGWEACDAIEMAVERQLPLEQITLSSDGGGCLPCFDPQGELQHM--DFGRASTLGETL 322

Query: 354 LINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPK 403
           +      K L+L+ V  + T   +  L    + G   VG + D +++N K
Sbjct: 323 VATLN--KGLSLETVLPMLTSNVANILRFKNK-GQIAVGFDADLLVMNEK 369


>4LCQ-A nrPDB
          Length = 520

 Score = 34.1 bits (76), Expect = 0.14,   Method: Composition-based stats.
 Identities = 12/63 (19%), Positives = 21/63 (33%), Gaps = 10/63 (15%)

Query: 34 LGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQYSFAGS 93
          + +   GKIV +           +    P      +     +PG +DTH H         
Sbjct: 45 VHIR-GGKIVEVGP---------DLRVPPGARVIDATDRLVIPGGIDTHTHMELAFMGTR 94

Query: 94 SID 96
          ++D
Sbjct: 95 AVD 97


>2ICS-A nrPDB
          Length = 379

 Score = 33.7 bits (75), Expect = 0.17,   Method: Composition-based stats.
 Identities = 53/371 (14%), Positives = 114/371 (30%), Gaps = 64/371 (17%)

Query: 54  LAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHR 113
           +A        E   L    +   G +D H+H  +                  Y +P E  
Sbjct: 32  VAATISGSAKETIHLEPGTYVSAGWIDDHVHCFEKMAL-------------YYDYPDEI- 77

Query: 114 FQNIDFAEEVYTRVVRRTLKNGTTTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMDL 173
                       + V   +  GTT A     IH    L     T+ FG    + K  +  
Sbjct: 78  ---------GVKKGVTTVIDAGTTGAE---NIHEFYDLAQQAKTNVFGL-VNISKWGIVA 124

Query: 174 NDTFPEYKETTEESIKETERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTR 233
            D   +  +     +K+  + + + +    +R+   V     ++    L  ++    + +
Sbjct: 125 QDELADLSKVQASLVKKAIQELPDFVVGIKARMSRTVIGDNGITP-LELAKQIQQ--ENQ 181

Query: 234 DLHIQSHISENRDEVEAVKNLYPSYKNYTSVYD--KNNLLTNKTVMAHGCYLSAEELNVF 291
           ++ +  HI      ++ +  L       T  ++  +N +L   T          +++  F
Sbjct: 182 EIPLMVHIGSAPPHLDEILALMEKGDVLTHCFNGKENGILDQAT----------DKIKDF 231

Query: 292 H--ERGASIAHCPNSNLSLSSGF----LNVLE-VLKHEVKIG-LGTDVAGGYSYSMLDAI 343
                   +         +  G      +V E  L+  +K   + TD+      +    +
Sbjct: 232 AWQAYNKGVV------FDIGHGTDSFNFHVAETALREGMKAASISTDIYIRNREN--GPV 283

Query: 344 RRAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPK 403
                    L +   +       E+    T   ++   L  + G  E+GK+ D  +   +
Sbjct: 284 YDLATTMEKLRVVGYDWP-----EIIEKVTKAPAENFHLTQK-GTLEIGKDADLTIFTIQ 337

Query: 404 ASDSPIDLFYG 414
           A +  +    G
Sbjct: 338 AEEKTLTDSNG 348


>1E9Y-B nrPDB
          Length = 569

 Score = 33.3 bits (74), Expect = 0.25,   Method: Composition-based stats.
 Identities = 14/50 (28%), Positives = 24/50 (48%)

Query: 353 LLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINP 402
           L   K +  +  +K      T+  + A G+   +G+ EVGK  D +L +P
Sbjct: 390 LKEEKGDNDNFRIKRYLSKYTINPAIAHGISEYVGSVEVGKVADLVLWSP 439


>4H9M-A nrPDB
          Length = 840

 Score = 32.9 bits (73), Expect = 0.28,   Method: Composition-based stats.
 Identities = 11/59 (18%), Positives = 24/59 (40%)

Query: 345 RAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPK 403
           +    +  L  +  +  +  ++      T+  + A G    +G+ EVGK  D ++  P 
Sbjct: 653 KMKAQTGPLKCDSSDNDNFRIRRYIAKYTINPAIANGFSQYVGSVEVGKLADLVMWKPS 711


>3SFW-A nrPDB
          Length = 461

 Score = 32.9 bits (73), Expect = 0.33,   Method: Composition-based stats.
 Identities = 58/425 (13%), Positives = 122/425 (28%), Gaps = 93/425 (21%)

Query: 34  LGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQYSFAGS 93
           +  SD+ +   L +  +   +  +      E+ + + + + +PG +D H H         
Sbjct: 11  VTASDTYQADVLIDGEKVVAIGSDLQATDAEVIDATGY-YLLPGGIDPHTHLDM------ 63

Query: 94  SIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTACYFATIHTDSSLLL 153
                                       + +    +     GTT+   F       SL  
Sbjct: 64  --------------------PFGGTVTSDNFFTGTKAAAFGGTTSIVDFCLTSKGESLHS 103

Query: 154 ADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESIKETERFVSEMLQKNYSRVKPIVTPR 213
           A  T     R   GK  +D         +  +  ++E E  V+    +  + +K  +  +
Sbjct: 104 AIATWHEKAR---GKAVIDYGFHL-MVSDANDHVLEELESVVN---NEGITSLKVFMAYK 156

Query: 214 FSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKN----------LYPSYKNYTS 263
             L   +  + +    AK     +Q H +EN D ++ +            +Y +Y     
Sbjct: 157 NVLMADDETLFKTLIRAKELGALVQVH-AENGDVLDYLTKQALAEGNTDPIYHAYTRPPE 215

Query: 264 VYDK--------NNLLTNKTVMAHGCYLSAEELNVFHER-----GASIAHCPN------- 303
              +          L   +  + H     A  +    E            CP        
Sbjct: 216 AEGEATGRAIALTALADAQLYVVHVSCADA--VRRIAEAREKGWNVYGETCPQYLVLDIT 273

Query: 304 ----SNLSLSSGFL--NVLEVL---------KHEVKIGLGTDVAGGYSYSMLDAIRRAVM 348
                +   +       + E           K+ +   +G+D          +  RR   
Sbjct: 274 ALEKPDFEGAKYVWSPPLREKWNQDVLWSALKNGILQTVGSDHCPFNFSGQKELGRRDFT 333

Query: 349 -----------VSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDA 397
                         IL    V +  ++L +   + +   ++  G+  + G   VG + D 
Sbjct: 334 KIPNGGPIIEDRMTILFSEGVRKGKISLNQFVDITSTKVAKLFGMFPQKGTIAVGSDADI 393

Query: 398 ILINP 402
           +L +P
Sbjct: 394 VLFDP 398


>3S9V-A nrPDB
          Length = 785

 Score = 32.5 bits (72), Expect = 0.40,   Method: Composition-based stats.
 Identities = 18/133 (13%), Positives = 36/133 (27%), Gaps = 8/133 (6%)

Query: 170 CMDLNDTFPEYKETTEESIKETERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNI 229
            M L      +  +   +     R  ++      + V               L   L  +
Sbjct: 218 IMKLQSKDGSFLSSPASTAAVFMRTGNKKCLDFLNFVLKKFGNHVPCHYPLDLFERLWAV 277

Query: 230 AKTRDLHIQSHISENRDEVEAV-------KNLYPSYKNYTSVYDKNNLLTNKTVMAHGCY 282
                L I  H  E   E           + +  + +N     D    +  + +  HG  
Sbjct: 278 DTVERLGIDRHFKEEIKEALDYVYSHWDERGIGWARENPVPDIDDTA-MGLRILRLHGYN 336

Query: 283 LSAEELNVFHERG 295
           +S++ L  F +  
Sbjct: 337 VSSDVLKTFRDEN 349


>4G7E-B nrPDB
          Length = 840

 Score = 32.5 bits (72), Expect = 0.41,   Method: Composition-based stats.
 Identities = 12/59 (20%), Positives = 22/59 (37%)

Query: 345 RAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPK 403
           +       L   +    +  +K      T+  + A G    +G+ EVGK  D ++  P 
Sbjct: 653 KMKSARGPLQPGEEANDNFRIKRYVAKYTINPAIANGFSQYVGSVEVGKLADLVMWKPS 711


>3TAC-A nrPDB
          Length = 361

 Score = 32.5 bits (72), Expect = 0.44,   Method: Composition-based stats.
 Identities = 39/272 (14%), Positives = 76/272 (27%), Gaps = 14/272 (5%)

Query: 25  PMEVLR---DHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDT 81
           P  V+R   +   G   + KIV + + +    L+ E   +   I  +  H   +  L   
Sbjct: 38  PFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKHPHIVELLETY 97

Query: 82  HIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTACY 141
                 Y          L     +    A+  F   +     Y R +   L+        
Sbjct: 98  SSDGMLYMVFEFMDGADLC---FEIVKRADAGFVYSEAVASHYMRQILEALRYCHDNNII 154

Query: 142 FATIHTDSSLLLADI------TDKFGQRAFVGKVCMDLNDTFPEYKETTEESIKETERFV 195
              +     LL +           FG    +G+  +              E +K      
Sbjct: 155 HRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFMAPEVVKREPYGK 214

Query: 196 SEMLQKNYSRVKPIVTPRFS-LSCSETLMGELGNIAKTRDLHIQSHISENRDE-VEAVKN 253
              +      +  +++         E L   +       +    SHISE+  + V  +  
Sbjct: 215 PVDVWGCGVILFILLSGCLPFYGTKERLFEGIIKGKYKMNPRQWSHISESAKDLVRRMLM 274

Query: 254 LYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSA 285
           L P+ +        +  L  +   A+  +L  
Sbjct: 275 LDPAERITVYEALNHPWLKERDRYAYKIHLPE 306


>4OTK-A nrPDB
          Length = 318

 Score = 32.1 bits (71), Expect = 0.58,   Method: Composition-based stats.
 Identities = 18/78 (23%), Positives = 33/78 (42%), Gaps = 2/78 (2%)

Query: 370 RLATLGGSQALGLDGEIGNFEVG-KEFDAILINPKASDSPIDLFYGDFFGDISEAVIQKF 428
            +A++ G Q +G   E    E G     +I +N + +   + L   +   D +E  +   
Sbjct: 20  HMASMTGGQQMGRGSEFVTGESGAAAAPSITLNDEHTMPVLGLGVAELSDDETERAVSAA 79

Query: 429 LYLGDDRNIEEVYVGGKQ 446
           L +G  R I+  Y  G +
Sbjct: 80  LEIG-CRLIDTAYAYGNE 96


>1FWC-C nrPDB
          Length = 567

 Score = 31.7 bits (70), Expect = 0.70,   Method: Composition-based stats.
 Identities = 13/58 (22%), Positives = 25/58 (43%)

Query: 345 RAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINP 402
           R  +    L     +  +  +K      T+  +   G+  E+G+ EVGK  D ++ +P
Sbjct: 380 RMKVQRGALAEETGDNDNFRVKRYIAKYTINPALTHGIAHEVGSIEVGKLADLVVWSP 437


>3QGK-C nrPDB
          Length = 568

 Score = 31.7 bits (70), Expect = 0.75,   Method: Composition-based stats.
 Identities = 13/50 (26%), Positives = 22/50 (44%)

Query: 353 LLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINP 402
           L   K +  +  +K      T+  +   G+   IG+ E GK  D ++ NP
Sbjct: 389 LTEEKGDNDNFRIKRYISKYTINPAITHGVSEYIGSVEEGKIADLVVWNP 438


>4TQT-A nrPDB
          Length = 497

 Score = 31.4 bits (69), Expect = 0.92,   Method: Composition-based stats.
 Identities = 33/220 (15%), Positives = 65/220 (29%), Gaps = 49/220 (22%)

Query: 34  LGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQYSFAGS 93
           + + D GKI  + ++ +             +    +   + MPG +D H H         
Sbjct: 34  ILIED-GKIAAIGDSLE------------GDEVIDASGCYVMPGGIDPHTHLQM------ 74

Query: 94  SIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTACYFATIHTDSSLLL 153
               P +                  ++ + +       L  GTT    F  +  DS   L
Sbjct: 75  ----PFM----------------GTYSSDDFDTGTAAALAGGTTMVVDF--VLPDSEGNL 112

Query: 154 ADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESIKETERFVSEMLQKNYSRVKPIVTPR 213
            D   ++ Q+A   +     +     + E    +  E    V   +       K  +  +
Sbjct: 113 LDALQEWFQKAGKARTDYSFHMAITGWNE---RTFNEMAEVVKRGINT----FKHFMAYK 165

Query: 214 FSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKN 253
            +L  ++  M                H +EN D V  ++ 
Sbjct: 166 GALMVNDDEMFASFQRCAELGAMPLVH-AENGDIVAQLQA 204



 Score = 28.7 bits (62), Expect = 5.6,   Method: Composition-based stats.
 Identities = 10/57 (17%), Positives = 23/57 (40%)

Query: 352 ILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDSP 408
           +L    V    LT  E   + +   ++ L +  + G    G + D ++ +P+ +   
Sbjct: 357 VLWTRGVRTGRLTPNEFVAVTSTNIAKILNIYPQKGAVVPGADADLVIWDPETTKKI 413


>1K1D-A nrPDB
          Length = 460

 Score = 31.4 bits (69), Expect = 0.93,   Method: Composition-based stats.
 Identities = 59/441 (13%), Positives = 122/441 (27%), Gaps = 99/441 (22%)

Query: 17  FVHSTWTCPMEVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMP 76
            + +          +  L + D GKI  + +  +++                +   +  P
Sbjct: 4   IIKNGTIVTATDTYEAHLLIKD-GKIAMIGQNLEEKGAE----------VIDAKGCYVFP 52

Query: 77  GLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGT 136
           G +D H H                                    ++ +          GT
Sbjct: 53  GGIDPHTHLDM--------------------------PLGGTVTKDDFESGTIAAAFGGT 86

Query: 137 TTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESIKETERFVS 196
           TT   F  +      L   I     +    GK  +D         E T++ ++E  + + 
Sbjct: 87  TTIIDFC-LTNKGEPLKKAIETWHNKAN--GKAVIDYGFHL-MISEITDDVLEELPKVLE 142

Query: 197 EMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKN--- 253
           E   +  + +K  +  +      +  +      AK     +  H +EN D ++ +     
Sbjct: 143 E---EGITSLKVFMAYKNVFQADDGTLYCTLLAAKELGALVMVH-AENGDVIDYLTKKAL 198

Query: 254 -------LYPSYKNYTSV--------YDKNNLLTNKTVMAHGCYLSA-EELNVFHERGAS 297
                  +Y +      +             L  ++  + H     A E++     +G  
Sbjct: 199 ADGNTDPIYHALTRPPELEGEATGRACQLTELAGSQLYVVHVTCAQAVEKIAEARNKGLD 258

Query: 298 I--AHCPN-----------SNLSLSSGFL--NVLEVLKHEVKI---------GLGTDVAG 333
           +    CP             N   +       + E    EV            LG+D   
Sbjct: 259 VWGETCPQYLVLDQSYLEKPNFEGAKYVWSPPLREKWHQEVLWNALKNGQLQTLGSDQCS 318

Query: 334 GYSYSMLDAIRRAVM-----------VSNILLINKVNEKSLTLKEVFRLATLGGSQALGL 382
                  +  R                 +IL    V +  +TL +   + +   ++  GL
Sbjct: 319 FDFKGQKELGRGDFTKIPNGGPIIEDRVSILFSEGVKKGRITLNQFVDIVSTRIAKLFGL 378

Query: 383 DGEIGNFEVGKEFDAILINPK 403
             + G   VG + D ++ +P 
Sbjct: 379 FPKKGTIVVGSDADLVIFDPN 399


>6HAW-A nrPDB
          Length = 438

 Score = 31.0 bits (68), Expect = 1.3,   Method: Composition-based stats.
 Identities = 10/41 (24%), Positives = 15/41 (36%)

Query: 240 HISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHG 280
           H+S     + A   L  S++ +   Y    LL    V  H 
Sbjct: 282 HLSSPLASIAATNKLCQSFQTFNICYADTGLLGAHFVCDHM 322


>3DC8-A nrPDB
          Length = 490

 Score = 30.6 bits (67), Expect = 1.3,   Method: Composition-based stats.
 Identities = 60/444 (13%), Positives = 115/444 (25%), Gaps = 96/444 (21%)

Query: 16  TFVHSTWTCPMEVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFM 75
           T +        ++     + V   G+IV +       +               +   + M
Sbjct: 3   TVIKGGTIVTADLTYKADVKVE-GGRIVEIGPNLSGAETLD------------ATGCYVM 49

Query: 76  PGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNG 135
           PG +D H H             P +                  ++ + +    R  L  G
Sbjct: 50  PGGIDPHTHLEM----------PFMG----------------TYSSDDFESGTRAALAGG 83

Query: 136 TTTACYFA-TIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESIKETERF 194
           TT    FA      S L    + D    RA            + E      E+I + +  
Sbjct: 84  TTMVVDFALPSPGQSLLEALTMWDNKSTRANCDYSFHMAITWWGEQVFNEMETIVKDKGI 143

Query: 195 VSEML------------QKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQS--- 239
            +                + +S  +                  +  +         S   
Sbjct: 144 NTFKHFMAYKGALMVDDDEMFSSFQRCAALGALPLVHAENGDVVAQLQAKLLAEGNSGPE 203

Query: 240 -HISENRDEVEA----------------VKNLYPSYKNYTSVYDKNNLLTNKTVMAHGC- 281
            H      EVE                 V  ++ S +       +      +        
Sbjct: 204 AHAYSRPAEVEGEAANRAIMIADMAGCPVYIVHTSCEQAHEAIRRARAKGMRVFGEPLIQ 263

Query: 282 YLSAEELNVFHE----RGASIAHCPNSN--------LSLSSGFLNV-----LEVLKHEVK 324
           +L+ +E   F +        +   P  N          L+SG L V           + +
Sbjct: 264 HLTLDETEYFDKDWDHAARRVMSPPFRNKLHQDSLWAGLASGSLQVVATDHCAFTTEQKR 323

Query: 325 IGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDG 384
            G+G           L+          +L    V    +T+ E   + +   ++ L +  
Sbjct: 324 FGVGDFTRIPNGTGGLED------RMPMLWTYGVATGRITMNEFVAVTSTNIAKILNIYP 377

Query: 385 EIGNFEVGKEFDAILINPKASDSP 408
           + G   VG + D ++ +PK S + 
Sbjct: 378 KKGAILVGADADLVVWDPKRSKTI 401


>6N91-A nrPDB
          Length = 340

 Score = 30.6 bits (67), Expect = 1.5,   Method: Composition-based stats.
 Identities = 15/104 (14%), Positives = 30/104 (28%), Gaps = 17/104 (16%)

Query: 231 KTRDLHIQSHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNV 290
           +   LH+  H  E        + +                + +     H      + ++ 
Sbjct: 188 RDAGLHVTVHAGEAAGPESMWQAIRDLGATR---------IGHGVKAIH----DPKLMDY 234

Query: 291 FHERGASIAHCPNSNLSLSS----GFLNVLEVLKHEVKIGLGTD 330
             +    I  C  SNL  S+        +   L+H +   + TD
Sbjct: 235 LAQHRIGIESCLTSNLQTSTVDSLATHPLKRFLEHGILACINTD 278


>3R64-A nrPDB
          Length = 508

 Score = 30.2 bits (66), Expect = 1.8,   Method: Composition-based stats.
 Identities = 18/106 (16%), Positives = 37/106 (34%), Gaps = 11/106 (10%)

Query: 295 GASIAHCPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILL 354
           G ++   P S+  ++ G +      +  V  G+ + VAG  S      I    +   +  
Sbjct: 176 GNAVVIKPASDTPVTGGVIPARIFEEAGVPAGVISTVAGAGS-----EIGDHFVTHAVPK 230

Query: 355 INKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILI 400
           +      +   + V  LA  GG        +    E+G     +++
Sbjct: 231 LISFTGSTPVGRRVGELAINGG------PMKTVALELGGNAPFVVL 270


>1GKR-A nrPDB
          Length = 458

 Score = 30.2 bits (66), Expect = 1.9,   Method: Composition-based stats.
 Identities = 13/61 (21%), Positives = 25/61 (40%), Gaps = 2/61 (3%)

Query: 26 MEVLRDHLLGVSDSGKIVF--LEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHI 83
           +V+  +   VS  G      L +  +   ++ +           +  +F MPG+VD H+
Sbjct: 2  FDVIVKNCRLVSSDGITEADILVKDGKVAAISADTSDVEASRTIDAGGKFVMPGVVDEHV 61

Query: 84 H 84
          H
Sbjct: 62 H 62


>4YHJ-A nrPDB
          Length = 584

 Score = 29.8 bits (65), Expect = 2.3,   Method: Composition-based stats.
 Identities = 24/135 (17%), Positives = 46/135 (34%), Gaps = 10/135 (7%)

Query: 181 KETTEESIKETERFVSEMLQKNYSRVKPIVT--PRFSLSCSETLMGELGNIAKTRDLHIQ 238
           +E  +    +TE +  +  +   S  + ++T  P   L C       +      +D+   
Sbjct: 396 EEVDQRIKNDTEEYSEKFSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDI--- 452

Query: 239 SHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASI 298
                N   +EA     P   +  +VY K+ L   +  +  G YL   + + +       
Sbjct: 453 -----NFRRLEANMLEPPFCPDPHAVYCKDVLDIEQFSVVKGIYLDTADEDFYARFATGC 507

Query: 299 AHCPNSNLSLSSGFL 313
              P  N  + SG  
Sbjct: 508 VSIPWQNEMIESGCF 522


>3CKY-A nrPDB
          Length = 301

 Score = 29.4 bits (64), Expect = 3.0,   Method: Composition-based stats.
 Identities = 25/122 (20%), Positives = 45/122 (36%), Gaps = 22/122 (18%)

Query: 286 EELNVFHERGASIAHCPNSNLSLSSGFLNVLEVLKHEVKIGLGTDV-------AGGYSYS 338
           +++    + GA  A    +NL L     ++ E L   VK GL  +        + G SY+
Sbjct: 159 KDIYHVGDTGAGDAVKIVNNLLLGCNMASLAEALVLGVKCGLKPETMQEIIGKSSGRSYA 218

Query: 339 MLDAIRRAVMVSNILLINKVNEKSLTLKEVFR-------------LAT--LGGSQALGLD 383
           M   + + +M  +      ++ +   L                  +AT    G +A+GL 
Sbjct: 219 MEAKMEKFIMSGDFAGGFAMDLQHKDLGLALEAGKEGNVPLPMTAMATQIFEGGRAMGLG 278

Query: 384 GE 385
            E
Sbjct: 279 RE 280


>1C8N-A nrPDB
          Length = 276

 Score = 29.4 bits (64), Expect = 3.1,   Method: Composition-based stats.
 Identities = 13/62 (20%), Positives = 26/62 (41%), Gaps = 2/62 (3%)

Query: 102 WLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTACYFATIHTDSSLLLADITDKFG 161
           W+T+ ++ A         A    T+ + R ++ G + A  F T     +++      +FG
Sbjct: 26  WVTEASWRAGQAPNKERAA--TVTKSIARKVRGGVSRAGGFVTAPVIGAMVTRPTVPRFG 83

Query: 162 QR 163
            R
Sbjct: 84  MR 85


>2VR2-A nrPDB
          Length = 541

 Score = 29.4 bits (64), Expect = 3.2,   Method: Composition-based stats.
 Identities = 49/309 (15%), Positives = 90/309 (29%), Gaps = 47/309 (15%)

Query: 60  FKPCEIREL-SHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNID 118
             P  +R L +  +  +PG +DTH H  Q+ F GS                     ++ID
Sbjct: 66  GAPAGLRVLDAAGKLVLPGGIDTHTHM-QFPFMGS---------------------RSID 103

Query: 119 FAEEVYTRVVRRTLKNGTTTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFP 178
              +         L  GTT    FA      SL+ A  T +      V          + 
Sbjct: 104 DFHQGTKAA----LSGGTTMIIDFAIPQKGGSLIEAFETWRSWADPKVCC-------DYS 152

Query: 179 EYKETTEESIKETERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQ 238
            +   T  S +  E     +  K  +  K  +  +     ++  + E  +  K      Q
Sbjct: 153 LHVAVTWWSDQVKEEMKILVQDKGVNSFKMFMAYKDLYMVTDLELYEAFSRCKEIGAIAQ 212

Query: 239 SHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASI 298
            H +EN D +                        ++            E  +     AS 
Sbjct: 213 VH-AENGDLIA-------EGAKKMLALGITGPEGHELCRPEAV---EAEATLRAITIASA 261

Query: 299 AHCPNSNLS-LSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDA-IRRAVMVSNILLIN 356
            +CP   +  +S     V+   + + K+  G  +A            +     ++ ++  
Sbjct: 262 VNCPLYIVHVMSKSAAKVIADARRDGKVVYGEPIAASLGTDGTHYWNKEWHHAAHHVMGP 321

Query: 357 KVNEKSLTL 365
            +     T 
Sbjct: 322 PLRPDPSTP 330


>1SQH-A nrPDB
          Length = 312

 Score = 29.4 bits (64), Expect = 3.3,   Method: Composition-based stats.
 Identities = 12/93 (12%), Positives = 30/93 (32%), Gaps = 11/93 (11%)

Query: 37  SDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQYSFAGSSID 96
           SD+G+++     +    L         E R L                A+         +
Sbjct: 217 SDTGELIAWIFQNDFSGLGMLQVLPKAERRGLGGLLA-----------AAMSREIARGEE 265

Query: 97  LPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVR 129
           + L  W+    + +E   + I + +++    ++
Sbjct: 266 ITLTAWIVATNWRSEALLKRIGYQKDLVNEWIK 298


>5NSQ-A nrPDB
          Length = 521

 Score = 29.0 bits (63), Expect = 3.9,   Method: Composition-based stats.
 Identities = 16/86 (18%), Positives = 32/86 (37%), Gaps = 3/86 (3%)

Query: 333 GGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNF--- 389
            G +  +++      +V    + +  NE S T   V  +ATL G+Q +            
Sbjct: 361 SGKTVEVINTDAEGRIVLGDGVFHATNELSFTPDVVIDMATLTGAQGIATGRHHAGLYVN 420

Query: 390 EVGKEFDAILINPKASDSPIDLFYGD 415
           E G E   +    ++ ++   + Y  
Sbjct: 421 EEGAEAAMLRAGRESGETCFPVLYCP 446


>3GIQ-A nrPDB
          Length = 480

 Score = 29.0 bits (63), Expect = 4.0,   Method: Composition-based stats.
 Identities = 42/227 (18%), Positives = 60/227 (26%), Gaps = 35/227 (15%)

Query: 34  LGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQYSFAGS 93
           LGV D G+I  + E                     +  +   PG +D H H         
Sbjct: 29  LGVRD-GRIAAIGELGAHPARHAW----------DASGKIVAPGFIDVHGHDDLMFV--- 74

Query: 94  SIDLPLLEWLTK----YTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTACYFATIHTDS 149
             + P L W T                        T      L         FA +    
Sbjct: 75  --EKPDLRWKTSQGITTVVVGNCGVSAAPAPLPGNTAAALALLGE----TPLFADVPAYF 128

Query: 150 SLLLADITDKFGQRAFVGKVCMDLND-TFPEYKETTEESIKETERFVSEMLQKNYSRVKP 208
           + L A         A VG   + L     P+   T  E     ++ + +MLQ        
Sbjct: 129 AALDAQ-RPMINVAALVGHANLRLAAMRDPQAAPTAAE-----QQAMQDMLQAALEAGAV 182

Query: 209 IVTPRFSLSCSETL----MGELGNIAKTRDLHIQSHISENRDEVEAV 251
             +   +           +  L  +A  R     SHI    D VEA 
Sbjct: 183 GFSTGLAYQPGAVAQAAELEGLARVAAERRRLHTSHIRNEADGVEAA 229


>6D8G-A nrPDB
          Length = 886

 Score = 29.0 bits (63), Expect = 4.2,   Method: Composition-based stats.
 Identities = 15/81 (18%), Positives = 29/81 (35%), Gaps = 3/81 (3%)

Query: 113 RFQNIDFAEEVYTRVVRRTLKNGTTTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMD 172
           +        E++ R      + G            D+   L ++ DK G  A+     +D
Sbjct: 333 KPIGPALTAEMHRRDFLLMKEMGANFIRISHYPQADA---LLEMCDKLGMLAWEEIPIID 389

Query: 173 LNDTFPEYKETTEESIKETER 193
           +    P Y +  E +++E  R
Sbjct: 390 IVPNTPGYGDNCERNLREMIR 410


>4OJZ-A nrPDB
          Length = 736

 Score = 28.7 bits (62), Expect = 5.2,   Method: Composition-based stats.
 Identities = 16/68 (23%), Positives = 28/68 (41%)

Query: 314 NVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLAT 373
           N+   +   V + +  D  GGY++       +A+  +  L     +EK LT  +   LA 
Sbjct: 63  NLDAFMAEGVVVPMPKDAGGGYTHEQHKRNYKAIRNAGFLYQVTGDEKYLTFAKDLLLAY 122

Query: 374 LGGSQALG 381
                +LG
Sbjct: 123 AKMYPSLG 130


>1BEV-3 nrPDB
          Length = 242

 Score = 28.7 bits (62), Expect = 6.0,   Method: Composition-based stats.
 Identities = 28/179 (15%), Positives = 54/179 (30%), Gaps = 7/179 (3%)

Query: 46  EEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTK 105
              S Q     E C            E F+PG V+  +  +Q      + +   +E + +
Sbjct: 7   GPGSYQFMTTDEDCSPCILPDFQPTPEIFIPGKVNNLLEIAQVESILEANNREGVEGVER 66

Query: 106 YTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTACYFATIHTDSSLLLADITDK---FGQ 162
           Y  P   +    D  +     +      +G  ++    T+    +     +       G 
Sbjct: 67  YVIPVSVQ----DALDAQIYALRLELGGSGPLSSSLLGTLAKHYTQWSGSVEITCMFTGT 122

Query: 163 RAFVGKVCMDLNDTFPEYKETTEESIKETERFVSEMLQKNYSRVKPIVTPRFSLSCSET 221
               GKV +       +     EE++  T       LQ + + V P ++       S  
Sbjct: 123 FMTTGKVLLAYTPPGGDMPRNREEAMLGTHVIWDFGLQSSITLVIPWISASHFRGVSND 181


>5YZA-A nrPDB
          Length = 525

 Score = 28.3 bits (61), Expect = 7.0,   Method: Composition-based stats.
 Identities = 7/57 (12%), Positives = 21/57 (36%)

Query: 352 ILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDSP 408
           ++    V    +   +   + +   ++   L    G   VG + D ++ +P +  + 
Sbjct: 364 VIWDKAVVTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTI 420


>4NML-A nrPDB
          Length = 275

 Score = 28.3 bits (61), Expect = 7.8,   Method: Composition-based stats.
 Identities = 14/82 (17%), Positives = 30/82 (36%), Gaps = 2/82 (2%)

Query: 301 CPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNE 360
            P      + G+  V   ++  +K+GLGT     +    +    +   + ++L +     
Sbjct: 2   NPQDKAKQAVGYFAVDTYVRSGMKVGLGTGTTAKFVVERIGQRMQEGSLKDLLCVPTSEA 61

Query: 361 KSLTLKEV-FRLATLGG-SQAL 380
                + +   L TL G +  L
Sbjct: 62  TRKQAESLGIPLTTLDGIADCL 83


  Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta
    Posted date:  Jan 3, 2023  9:05 PM
  Number of letters in database: 10,336,785
  Number of sequences in database:  36,641
  
Lambda     K      H
   0.311    0.119    0.295 

Lambda     K      H
   0.267   0.0362    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,357,205
Number of Sequences: 36641
Number of extensions: 501498
Number of successful extensions: 1861
Number of sequences better than 10.0: 87
Number of HSP's better than 10.0 without gapping: 75
Number of HSP's successfully gapped in prelim test: 43
Number of HSP's that attempted gapping in prelim test: 1609
Number of HSP's gapped (non-prelim): 161
length of query: 454
length of database: 10,336,785
effective HSP length: 100
effective length of query: 354
effective length of database: 6,672,685
effective search space: 2362130490
effective search space used: 2362130490
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.5 bits)
S2: 60 (27.9 bits)