BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q9Y2T3 (454 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 3E0L-A nrPDB 926 0.0 2I9U-A nrPDB 259 2e-69 2OOD-A nrPDB 169 2e-42 4DYK-A nrPDB 137 9e-33 4DZH-A nrPDB 135 2e-32 4F0R-A nrPDB 120 1e-27 3LNP-A nrPDB 120 1e-27 3HPA-A nrPDB 83 2e-16 2PAJ-A nrPDB 78 8e-15 2PLM-A nrPDB 75 6e-14 4V1Y-A nrPDB 74 1e-13 4LH8-A nrPDB 59 5e-09 3V7P-A nrPDB 55 7e-08 2IMR-A nrPDB 46 4e-05 4F0L-A nrPDB 43 3e-04 1YRR-A nrPDB 32 0.46 3IV8-A nrPDB 32 0.56 3MKV-A nrPDB 31 1.2 2P9B-A nrPDB 30 1.6 3IEQ-A nrPDB 30 2.3 5XJN-A nrPDB 30 2.7 2XP1-A nrPDB 28 7.7 2XDQ-A nrPDB 28 9.6 4WHB-E nrPDB 28 9.8 >3E0L-A nrPDB Length = 455 Score = 926 bits (2392), Expect = 0.0, Method: Compositional matrix adjust. Identities = 448/454 (98%), Positives = 448/454 (98%), Gaps = 2/454 (0%) Query: 1 MCAAQMPPLAHIFRGTFVHSTWTCPMEVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCF 60 MCAAQMPPLAHIFRGTFVHSTWTCPMEVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCF Sbjct: 4 MCAAQMPPLAHIFRGTFVHSTWTCPMEVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCF 63 Query: 61 KPCEIRELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFA 120 KPCEIRELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFA Sbjct: 64 KPCEIRELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFA 123 Query: 121 EEVYTRVVRRTLKNGTTTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEY 180 EEVYTRVVRRTLKNGTTTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEY Sbjct: 124 EEVYTRVVRRTLKNGTTTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEY 183 Query: 181 KETTEESIKETERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSH 240 KETTEESIKETERFVSEMLQKNYSRVKPIVTP SETLMGELGNIAKTRDLHIQSH Sbjct: 184 KETTEESIKETERFVSEMLQKNYSRVKPIVTP--GNGVSETLMGELGNIAKTRDLHIQSH 241 Query: 241 ISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAH 300 ISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAH Sbjct: 242 ISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAH 301 Query: 301 CPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNE 360 CPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNE Sbjct: 302 CPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNE 361 Query: 361 KSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDSPIDLFYGDFFGDI 420 KSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDSPIDLFYGDFFGDI Sbjct: 362 KSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDSPIDLFYGDFFGDI 421 Query: 421 SEAVIQKFLYLGDDRNIEEVYVGGKQVVPFSSSV 454 SEAVIQKFLYLGDDRNIEEVYVGGKQVVPFSSSV Sbjct: 422 SEAVIQKFLYLGDDRNIEEVYVGGKQVVPFSSSV 455 >2I9U-A nrPDB Length = 439 Score = 259 bits (662), Expect = 2e-69, Method: Compositional matrix adjust. Identities = 167/444 (37%), Positives = 249/444 (56%), Gaps = 37/444 (8%) Query: 12 IFRGTFVHSTWTCPMEVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPC-EIRELSH 70 IF+G + + + +++D + V D GKI AS L ++ P + R Sbjct: 12 IFKGNLIFTKTSDKFTIMKDSYIVVID-GKI-----ASVSSNLPDKYKGNPIIDFR---- 61 Query: 71 HEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRR 130 + +PG+ D H HASQY G +D LL WL YTFP E +F N+D+A++ Y R+++ Sbjct: 62 NNIIIPGMNDLHAHASQYKNLGIGMDKELLPWLNNYTFPEEAKFLNVDYAKKTYGRLIKD 121 Query: 131 TLKNGTTTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEY-KETTEESIK 189 +KNGTT FAT+H DS++ L ++ K G A+VGKV MD N P+Y E S+ Sbjct: 122 LIKNGTTRVALFATLHKDSTIELFNMLIKSGIGAYVGKVNMDYN--CPDYLTENYITSLN 179 Query: 190 ETERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVE 249 +TE + + K+ + VKPI+TPRF SCS LM LG ++ L +QSH+SEN DE+ Sbjct: 180 DTEEIILKYKDKS-NIVKPIITPRFVPSCSNELMDGLGKLSYKYRLPVQSHLSENLDEIA 238 Query: 250 AVKNLYPSYKNYTSVYDKNNLLTNK-TVMAHGCYLSAEELNVFHERGASIAHCPNSNLSL 308 VK+L+ Y VYDK L N T+MAH + S EE+N+ +I HCP SN +L Sbjct: 239 VVKSLHKKSNFYGEVYDKFGLFGNTPTLMAHCIHSSKEEINLIKRNNVTIVHCPTSNFNL 298 Query: 309 SSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNEKS-----L 363 SG + V + L + + LG+D++ G++ S+ I A+ S I K E L Sbjct: 299 GSGMMPVRKYLNLGINVVLGSDISAGHTCSLFKVIAYAIQNSKI----KWQESGKKDMFL 354 Query: 364 TLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDSPIDLFYGDFFGDISEA 423 + E F +AT G G++G+FE G +FDA++IN DS +L+ D+ D++E Sbjct: 355 STSEAFYMATKKGGSFF---GKVGSFEEGYDFDALVIN----DS--NLYPEDY--DLTER 403 Query: 424 VIQKFLYLGDDRNIEEVYVGGKQV 447 +++F+YLGDDRNI + YV G ++ Sbjct: 404 -LERFIYLGDDRNIMKRYVCGNEI 426 >2OOD-A nrPDB Length = 475 Score = 169 bits (428), Expect = 2e-42, Method: Compositional matrix adjust. Identities = 121/406 (29%), Positives = 193/406 (47%), Gaps = 29/406 (7%) Query: 67 ELSH--HEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVY 124 E++H +PG +D HIH Q G+ + LL WL K +P E ++++ ++A E Sbjct: 62 EITHIKDRIIVPGFIDGHIHLPQTRVLGAYGEQ-LLPWLQKSIYPEEIKYKDRNYAREGV 120 Query: 125 TRVVRRTLKNGTTTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEYKETT 184 R + L GTTT F + ++ L + + R G +D N E+ +T Sbjct: 121 KRFLDALLAAGTTTCQAFTSSSPVATEELFEEASRRNMRVIAGLTGIDRNAP-AEFIDTP 179 Query: 185 EESIKETERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTR-DLHIQSHISE 243 E ++++R +++ K R +TPRF+ S L+ + D + +HISE Sbjct: 180 ENFYRDSKRLIAQYHDK--GRNLYAITPRFAFGASPELLKACQRLKHEHPDCWVNTHISE 237 Query: 244 NRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAHCPN 303 N E V +P ++Y VY+K +L+ K HG YLS E ++GA++ CP Sbjct: 238 NPAECSGVLVEHPDCQDYLGVYEKFDLVGPKFSGGHGVYLSNNEFRRMSKKGAAVVFCPC 297 Query: 304 SNLSLSSGFLNVLEVL--KHEVKIGLGTDVAGGYSYSM---LDAIRRAVMVSNILLINKV 358 SNL L SG + +H VK+ GTDV GG +SM LD + M +N LL + Sbjct: 298 SNLFLGSGLFRLGRATDPEHRVKMSFGTDVGGGNRFSMISVLDDAYKVGMCNNTLLDGSI 357 Query: 359 NEKSLTLKEV----------FRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKAS--- 405 + L E F TLGG++ L +D ++GNFE GKE D + ++P Sbjct: 358 DPSRKDLAEAERNKLSPYRGFWSVTLGGAEGLYIDDKLGNFEPGKEADFVALDPNGGQLA 417 Query: 406 ----DSPIDLFYGDFFGDISEAVIQKFLYLGDDRNIEEVYVGGKQV 447 S I G D + +++ + +GDDR ++E +V GK++ Sbjct: 418 QPWHQSLIADGAGPRTVDEAASMLFAVMMVGDDRCVDETWVMGKRL 463 >4DYK-A nrPDB Length = 451 Score = 137 bits (345), Expect = 9e-33, Method: Compositional matrix adjust. Identities = 115/436 (26%), Positives = 198/436 (45%), Gaps = 44/436 (10%) Query: 21 TWTCPME----VLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMP 76 TW P+E VLRDH LG+ D G+I + Q + EIREL P Sbjct: 15 TWIVPVEPAGVVLRDHALGIRD-GQIALVAPREQAMR------HGATEIRELPGM-LLAP 66 Query: 77 GLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGT 136 GLV+ H H++ F G + DLPL+ WL + +PAE ++ + DF + + +K G Sbjct: 67 GLVNAHGHSAMSLFRGLADDLPLMTWLQDHIWPAEGQWVSEDFIRDGTELAIAEQVKGGI 126 Query: 137 TTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESIKETERFVS 196 T F+ ++ + + D G RA V +D P +++ E+I++ Sbjct: 127 TC---FSDMYFYPQAICGVVHDS-GVRAQVAIPVLDF--PIPGARDSA-EAIRQGMALFD 179 Query: 197 EMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKNLYP 256 ++ K++ R++ P + S+ + ++ + + D IQ H+ E EVE + + Sbjct: 180 DL--KHHPRIRIAFGPHAPYTVSDDKLEQILVLTEELDASIQMHVHETAFEVE--QAMER 235 Query: 257 SYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAHCPNSNLSLSSGFLNVL 316 + + + + LL + H + ++L + E +S+ HCP SNL L+SGF V Sbjct: 236 NGERPLARLHRLGLLGPRFQAVHMTQVDNDDLAMLVETNSSVIHCPESNLKLASGFCPVE 295 Query: 317 EVLKHEVKIGLGTD-VAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATLG 375 ++ + V + +GTD A +L R A +++ + +L R+ATL Sbjct: 296 KLWQAGVNVAIGTDGAASNNDLDLLGETRTAALLAKAVYGQAT---ALDAHRALRMATLN 352 Query: 376 GSQALGLDGEIGNFEVGKEFDAILINPKASDSPIDLFYGDFFGDISEAV---IQKFLYLG 432 G++ALGL+ IG+ E GK DL D G + V + + +Y Sbjct: 353 GARALGLERLIGSLEAGKA--------------ADLVAFDLSGLAQQPVYDPVSQLIYAS 398 Query: 433 DDRNIEEVYVGGKQVV 448 + V+VGG+Q++ Sbjct: 399 GRDCVRHVWVGGRQLL 414 >4DZH-A nrPDB Length = 472 Score = 135 bits (341), Expect = 2e-32, Method: Compositional matrix adjust. Identities = 113/443 (25%), Positives = 191/443 (43%), Gaps = 55/443 (12%) Query: 17 FVHSTWTCPME----VLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHE 72 + + + P+E VL DH + VS+ + L A + + F P R +S + Sbjct: 17 LIEAGYVVPIEPHAVVLEDHAVAVSNGVIVAVLPTADARVR------FAPA--RTVSRPD 68 Query: 73 F-FMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRT 131 MPGLV+ H H G + DLPL+ WL ++ +P E +F + T + Sbjct: 69 AALMPGLVNAHTHNPMTLLRGVADDLPLMVWLQQHIWPVEAAVIGPEFVADGTTLAIAEM 128 Query: 132 LKNGTTTAC---YFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESI 188 L+ GTT +FA + A + + G RA VG V +D FP T + Sbjct: 129 LRGGTTCVNENYFFADVQ-------AAVYKQHGFRALVGAVIID----FP-----TAWAS 172 Query: 189 KETERFVSEMLQKNYSRVKPIVTPRFSLSCSETL----MGELGNIAKTRDLHIQSHISEN 244 + E F + R P+++ F+ T+ + +A D+ + H E Sbjct: 173 SDDEYFARAGELHDQWRDDPLISTAFAPHAPYTVNDANFERVRMLADQLDMPVHLHTHET 232 Query: 245 RDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAHCPNS 304 EV Y + + D+ L+ ++ + H L+ E+++ ERG S+ HCP S Sbjct: 233 AQEVADSVAQY--GQRPLARLDRLGLVNDRLIAVHMTQLTEAEIHLCAERGVSVVHCPES 290 Query: 305 NLSLSSGFLNVLEVLKHEVKIGLGTD-VAGGYSYSMLDAIRRAVMVSNILLINKVNEKSL 363 NL L+SGF + + V + +GTD A M R A +++ + + +L Sbjct: 291 NLKLASGFCPACALQRASVNLAIGTDGCASNNDLDMFSENRTAAILAKAV---ANDATAL 347 Query: 364 TLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDS-PIDLFYGDFFGDISE 422 R ATLGG++ALG IG+ EVGK+ D + ++ A ++ P+ Sbjct: 348 DAATTLRAATLGGARALGFGDRIGSIEVGKQADLVCVDLSALETQPL------------H 395 Query: 423 AVIQKFLYLGDDRNIEEVYVGGK 445 V+ + +Y + +V++ GK Sbjct: 396 HVLSQLIYAAGRHQVTDVWIAGK 418 >4F0R-A nrPDB Length = 447 Score = 120 bits (301), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 102/378 (26%), Positives = 179/378 (47%), Gaps = 27/378 (7%) Query: 27 EVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHAS 86 EVL +H + + D GKI + A+ L + E EL H MPGL++ H H++ Sbjct: 23 EVLENHAIAIRD-GKIAAIIPAADAAGLEAD------ERLELPDH-VLMPGLINLHGHSA 74 Query: 87 QYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTA--CYFAT 144 G + D L++WLT Y +P E + + DF + + ++ GTTT YF Sbjct: 75 MSLLRGLADDKALMDWLTNYIWPTEGKHVHDDFVFDGSLLAMGEMIRGGTTTINDMYFYN 134 Query: 145 IHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFP-EYKETTEESIKETERFVSEMLQKNY 203 + L + G R FVG ++ FP Y ++ I + S+ L ++ Sbjct: 135 AAVARAGLAS------GMRTFVGCSILE----FPTNYASNADDYIAKGMAERSQFLGEDL 184 Query: 204 SRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKNLYPSYKNYTS 263 + + P + S+ ++ +A+ D+ I HI E DEV ++ + + Sbjct: 185 --LTFTLAPHAPYTVSDDTFRKVVTLAEQEDMLIHCHIHETADEVN--NSVKEHGQRPLA 240 Query: 264 VYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAHCPNSNLSLSSGFLNVLEVLKHEV 323 + LL+ + V AH +L+ E+ + G S AH P SN+ L+SG V +++ V Sbjct: 241 RLQRLGLLSPRLVAAHMVHLNDAEVELAARHGLSTAHNPASNMKLASGISPVSKLMDAGV 300 Query: 324 KIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLD 383 +G+GTD G S + LD + + + + + ++ S+ R+ATL G++ALG+ Sbjct: 301 AVGIGTD--GAASNNKLDMLAETRLAALLAKVGTLDPTSVPAAAAIRMATLNGARALGIA 358 Query: 384 GEIGNFEVGKEFDAILIN 401 ++G+ +VGK+ D I ++ Sbjct: 359 DKVGSVKVGKQADLIALD 376 >3LNP-A nrPDB Length = 468 Score = 120 bits (300), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 117/450 (26%), Positives = 196/450 (43%), Gaps = 62/450 (13%) Query: 18 VHSTWTCPME----------VLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPC-EIR 66 ++S W P+E +L DH L + D G I+ +E S C P E Sbjct: 27 INSHWIIPIENTTDHNLVSNILIDHCLLIKD-GIILAIEPQSS--------CQIPATETL 77 Query: 67 ELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTR 126 +L + MPG V+ H HA+ F G + DLPL+ WL ++ +PAE + + F ++ Sbjct: 78 DLGQ-QVLMPGWVNAHGHAAMSLFRGLADDLPLMTWLQEHVWPAEAQHVDEHFVKQGTEL 136 Query: 127 VVRRTLKNGTTTAC--YFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFP-EYKET 183 + +++GTTT YF + + L A G RA +D FP Y + Sbjct: 137 AIAEMIQSGTTTFADMYFYPQQSGEAALAA------GIRAVCFAPVLD----FPTNYAQN 186 Query: 184 TEESIKET----ERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQS 239 +E I++ +RF + + + V+ P + S+ + E+ ++ D+ +Q Sbjct: 187 ADEYIRKAIECNDRFNNHPMNEQ-GLVQIGFGPHAPYTVSDEPLKEITMLSDQLDMPVQI 245 Query: 240 HISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIA 299 H+ E EV ++L K T L + H + ++ + + GASI Sbjct: 246 HLHETDFEVS--ESLETFNKRPTQRLADIGFLNERVSCVHMTQVDDGDIKILQKTGASII 303 Query: 300 HCPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVN 359 HCP SNL L+SGF + ++ + + +GTD G S + LD + LL V+ Sbjct: 304 HCPESNLKLASGFCPIAKLSAANIPLAIGTD--GAASNNDLDMFSETKTAA--LLAKGVS 359 Query: 360 EKSLTLK--EVFRLATLGGSQALGLDGEIGNFEVGKEFD--AILINPKASDSPIDLFYGD 415 + + + E +ATLGG++ALG+D G+ + GK D AI +N +S D Sbjct: 360 QDASAIPAIEALTMATLGGARALGIDDITGSLKPGKAADIQAIDLNTLSSQPVFD----- 414 Query: 416 FFGDISEAVIQKFLYLGDDRNIEEVYVGGK 445 + +Y + V+V G+ Sbjct: 415 --------PVSHMVYCTKSTQVSHVWVNGR 436 >3HPA-A nrPDB Length = 479 Score = 83.2 bits (204), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 93/382 (24%), Positives = 171/382 (44%), Gaps = 35/382 (9%) Query: 29 LRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQ- 87 LRD L + D+ +IV + +++ + A E + +L H +PGLV+TH H Q Sbjct: 49 LRDAGLYIEDN-RIVAVGPSAELPETADE-------VLDLRGH-LVIPGLVNTHHHMYQS 99 Query: 88 -YSFAGSSIDLPLLEWLTK-YTFPAEHRFQNIDFAEEVYT-RVVRRTLKNGTTTACYFAT 144 ++ + L WLT Y A + I EV T + L++G TT+ Sbjct: 100 LTRAVPAAQNAELFGWLTNLYKIWAHLTPEMI----EVSTLTAMAELLQSGCTTSSDHLY 155 Query: 145 IHTDSSLLLADI--TDKFGQRAFVGKVCMDL---NDTFP--EYKETTEESIKETERFVSE 197 I+ + S L I + G R + M + + P E + +++T+R + Sbjct: 156 IYPNGSRLDDSIGAAQRIGMRFHASRGAMSVGQRDGGLPPDSVVEREPDILRDTQRLIET 215 Query: 198 ML-QKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKNLYP 256 + Y+ ++ +V P S S LM + +A+ + + +H++EN +++ + Sbjct: 216 YHDEGRYAMLRVVVAPCSPFSVSRDLMRDAAVLAREYGVSLHTHLAENVNDIAYSRE--- 272 Query: 257 SYKNYTSVYDKN-NLLTNKTVMAHGCYLSAEELNVFHERGASIAHCPNSNLSLSSGFLNV 315 + + Y ++ + + AH L + +F G +AHCP SN+ L+SG V Sbjct: 273 KFGMTPAEYAEDLGWVGHDVWHAHCVQLDDAGIGLFARTGTGVAHCPCSNMRLASGIAPV 332 Query: 316 LEVLKHEVKIGLGTD-VAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATL 374 ++ V +GLG D A M+ +R+A+++ + ++T +E +ATL Sbjct: 333 KKMRLAGVPVGLGVDGSASNDGAQMVAEVRQALLLQRV----GFGPDAMTAREALEIATL 388 Query: 375 GGSQALGLDGEIGNFEVGKEFD 396 GG++ L D +IG + G D Sbjct: 389 GGAKVLNRD-DIGALKPGMAAD 409 >2PAJ-A nrPDB Length = 492 Score = 77.8 bits (190), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 87/357 (24%), Positives = 146/357 (40%), Gaps = 49/357 (13%) Query: 76 PGLVDTHIHASQYSFAG--SSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLK 133 P V+TH H Q G + +D L WL + RF+ + F E + R L Sbjct: 70 PAWVNTHHHLFQSLLKGEPAGLDATLTPWLAATPY----RFRAL-FDERRFRLAARIGLI 124 Query: 134 NGTTTAC---------YFATIHTDSSLLLADITDKFGQRAFV-----GKVCMDLNDTFPE 179 + C Y+ + DSS +L + +K G R FV L P Sbjct: 125 ELARSGCATVADHNYVYYPGMPFDSSAILFEEAEKLGLR-FVLLRGGATQTRQLEADLPT 183 Query: 180 --YKETTEESIKETERFVSEMLQKNYSRVKPIV----TPRFSLSCSETLMGELGNIAKTR 233 ET + + + ER + + ++ +V T +S+S E M E +A+ Sbjct: 184 ALRPETLDAYVADIERLAARYHDASPRAMRRVVMAPTTVLYSISPRE--MRETAAVARRL 241 Query: 234 DLHIQSHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHE 293 L + SH+SE ++ ++Y K+ + +++ L + AH + A+E+ + + Sbjct: 242 GLRMHSHLSETVGYQDSAYSMY--GKSPVAFCGEHDWLGSDVWYAHLVKVDADEIALLAQ 299 Query: 294 RGASIAHCPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMV---- 349 G +AHCP SN L SG V E+ V + +G D G S D I M Sbjct: 300 TGTGVAHCPQSNGRLGSGICPVREMADAGVPVSIGVD--GAASNEAADMISEVHMTWLAQ 357 Query: 350 -SNILLINKVNEK---------SLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFD 396 + + ++ + + + ++ EV T GG++ +GLD E+G VG D Sbjct: 358 RARLGMLAQPAYRGGSFEGGAGAASIAEVIHWGTAGGARVMGLD-EVGKVAVGYAAD 413 >2PLM-A nrPDB Length = 406 Score = 75.1 bits (183), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 79/330 (23%), Positives = 128/330 (38%), Gaps = 36/330 (10%) Query: 75 MPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKN 134 MP L +TH HA G + DL EWL P E R + Y + ++ Sbjct: 48 MPALFNTHTHAPMTLLRGVAEDLSFEEWLFSKVLPIEDRLTE----KMAYYGTILAQMEM 103 Query: 135 GTTTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESIKETERF 194 F ++ + + D FG RA + + +D N E + E F Sbjct: 104 ARHGIAGFVDMYFHEEWIAKAVRD-FGMRALLTRGLVDSNGDDGGRLEENLKLYNEWNGF 162 Query: 195 VSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDE---VEAV 251 R+ P CSE + + + AK+ + + H+ E E +E + Sbjct: 163 --------EGRIFVGFGPHSPYLCSEEYLKRVFDTAKSLNAPVTIHLYETSKEEYDLEDI 214 Query: 252 KNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAHCPNSNLSLSSG 311 N+ L KT+ AH +L V + ++H P SNL L +G Sbjct: 215 LNI--------------GLKEVKTIAAHCVHLPERYFGVLKDIPFFVSHNPASNLKLGNG 260 Query: 312 FLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRL 371 V +++H +K+ LGTD G S + L+ + S LL N ++L + ++ Sbjct: 261 IAPVQRMIEHGMKVTLGTD--GAASNNSLNLFFEMRLAS--LLQKAQNPRNLDVNTCLKM 316 Query: 372 ATLGGSQALGLDGEIGNFEVGKEFDAILIN 401 T G+QA+G G E G D ++I+ Sbjct: 317 VTYDGAQAMGFKS--GKIEEGWNADLVVID 344 >4V1Y-A nrPDB Length = 494 Score = 74.3 bits (181), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 90/401 (22%), Positives = 162/401 (40%), Gaps = 49/401 (12%) Query: 27 EVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHAS 86 VL D + V D G+IV L + E P + + + +PG ++ H H + Sbjct: 39 RVLGDSWVHVQD-GRIVAL-------GVHAESVPPPADRVIDARGKVVLPGFINAHTHVN 90 Query: 87 QYSF-AGSSIDLPLLEWLTKYTFPAEH--RFQNIDFAEEVYTRVVRR----TLKNGTTTA 139 Q G S +WL +P + R +++ A +Y R T+ +A Sbjct: 91 QILLRGGPSHGRQFYDWLFNVVYPGQKAMRPEDVAVAVRLYCAEAVRSGITTINENADSA 150 Query: 140 CYFATIHTDSSLLLADITDKFGQRAFVGKVCMD------------LNDTFPEYK--ETTE 185 Y I + + + G R ++ D L P+ + E Sbjct: 151 IYPGNIEAAMA-----VYGEVGVRVVYARMFFDRMDGRIQGYVDALKARSPQVELCSIME 205 Query: 186 ESIKETERFVSEMLQKNY-----SRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSH 240 E+ +R + L Y R+ P + + + M A+ R + H Sbjct: 206 ETAVAKDRITA--LSDQYHGTAGGRISVWPAPATTTAVTVEGMRWAQAFARDRAVMWTLH 263 Query: 241 ISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAH 300 ++E+ D E + + P+ Y Y LL + +AH Y +++ + H +A Sbjct: 264 MAES-DHDERIHGMSPA--EYMECY---GLLDERLQVAHCVYFDRKDVRLLHRHNVKVAS 317 Query: 301 CPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNE 360 SN L SG V E+++ + +G+GTD G S ++ I +++I + Sbjct: 318 QVVSNAYLGSGVAPVPEMVERGMAVGIGTD--NGNSNDSVNMIGDMKFMAHIHRAVHRDA 375 Query: 361 KSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILIN 401 LT +++ +AT+ G+++LG+D EIG+ E GK D IL++ Sbjct: 376 DVLTPEKILEMATIDGARSLGMDHEIGSIETGKRADLILLD 416 >4LH8-A nrPDB Length = 469 Score = 58.5 bits (140), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 79/346 (22%), Positives = 137/346 (39%), Gaps = 35/346 (10%) Query: 75 MPGLVDTHIHASQYSFAGSSIDLPLLE------WLTKYTFPAEHRFQNIDFAEEVYTRVV 128 +PGL+++H Q+ + G+ +P LE WL + +++ F +V V Sbjct: 69 LPGLINSH----QHLYEGAMRAIPQLERVTMASWLEGVLTRSAGWWRDGKFGPDVIREVA 124 Query: 129 R----RTLKNGTTTAC----YFATIHTDSSL-LLADITDKFGQRAFVGKVCMDLNDTFPE 179 R +L G TT +F DS + + G R + M L + E Sbjct: 125 RAVLLESLLGGITTVADQHPFFPGATADSYIDATIEAATDLGIRFHAVRSSMTLGKS--E 182 Query: 180 YKETTEESIKETERFVSEMLQ--KNYSRVKPIVTPRFSLS-CS-----ETLMGELGNIAK 231 + ++ +R V L Y +P R +L C L +A Sbjct: 183 GGFCDDLFVEPVDRVVQHCLGLIDQYHEPEPFGMVRIALGPCGVPYDKPELFEAFAQMAA 242 Query: 232 TRDLHIQSHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVF 291 D+ + +H E D +LY +K+ +++ +AH EE+ F Sbjct: 243 DYDVRLHTHFYEPLD-AGMSDHLY--GMTPWRFLEKHGWASDRVWLAHAVVPPREEIPEF 299 Query: 292 HERGASIAHCPNSNLSLSSGFLNVLEVLKHEVKIGLG-TDVAGGYSYSMLDAIRRAVMVS 350 + G +IAH +L + G + E L + +G G T A ++L +R A + Sbjct: 300 ADAGVAIAHLIAPDLRMGWGLAPIREYLDAGITVGFGTTGSASNDGGNLLGDLRLAALAH 359 Query: 351 NILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFD 396 N+ EK L+ +E+ R+AT G ++ LG ++G E G+ D Sbjct: 360 RPADPNE-PEKWLSARELLRMATRGSAECLGRP-DLGVLEEGRAAD 403 >3V7P-A nrPDB Length = 427 Score = 54.7 bits (130), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 66/235 (28%), Positives = 99/235 (42%), Gaps = 25/235 (10%) Query: 192 ERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAV 251 ERF +N R K V S L +IAK + H E+R E E + Sbjct: 159 ERFHQSKKHEN-ERFKAAVAIHSPYSVHYILAKRALDIAKKYGSLVSVHFMESRAEREWL 217 Query: 252 -------KNLYPSYKNYTS-VYDKNNLLTN----KTVMAHGCYLSAEELNVFHERGASIA 299 + + N T V D + L T+ H + + EE+ A I Sbjct: 218 DKGSGEFAKFFKEFLNQTRPVNDTKSFLELFKELHTLFVHMVWANEEEIQTIASYNAHII 277 Query: 300 HCPNSNLSLSSGFLNVLEVLKHEVKIGLGTD-VAGGYSYSMLDAIRRAVMVSNILLINKV 358 HCP SN L +G L+ LE +K + + TD ++ YS +M + ++ A L ++ Sbjct: 278 HCPISNRLLGNGVLD-LEKIK-SIPYAIATDGLSSNYSLNMYEELKAA------LFVHPN 329 Query: 359 NEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILIN-PKASDSPIDLF 412 E + KE+ AT G ALG +G G VGK+ D LI+ P+ + DL+ Sbjct: 330 KEATTFAKELIIRATKAGYDALGFEG--GEIAVGKDADMQLIDLPEGLTNVEDLY 382 >2IMR-A nrPDB Length = 420 Score = 45.8 bits (107), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 69/327 (21%), Positives = 124/327 (37%), Gaps = 56/327 (17%) Query: 81 THIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTAC 140 TH+ S Y F LP +W+ + H + + A+ + R L G Sbjct: 100 THLDMSAYEFQA----LPYFQWIPEVVIRGRH-LRGVAAAQAGADTLTR--LGAGGVGDI 152 Query: 141 YFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPE-YKETTEESIKETERFVSEML 199 +A D+ L D++ G + ++ + FP+ E + ER+ L Sbjct: 153 VWAPEVMDALLAREDLS---------GTLYFEVLNPFPDKADEVFAAARTHLERW--RRL 201 Query: 200 QKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKN------ 253 ++ R+ ++P + S LM L + A L +Q H++E+ E+E + Sbjct: 202 ERPGLRLG--LSPHTPFTVSHRLMRLLSDYAAGEGLPLQIHVAEHPTELEMFRTGGGPLW 259 Query: 254 ------LYP----------SYKNYTSV--YDKNNLLTNKTVMAHGCYLSAEELNVFHERG 295 LYP + T V D+ +L + + H ++ +++ G Sbjct: 260 DNRMPALYPHTLAEVIGREPGPDLTPVRYLDELGVLAARPTLVHMVNVTPDDIARVARAG 319 Query: 296 ASIAHCPNSNLSLSSGFLNVLEVLKHEVKIGLGTD-VAGGYSYSMLDAIRRAVMVSNILL 354 ++ CP SN L G + V++ LGTD VA G + + +R V + L Sbjct: 320 CAVVTCPRSNHHLECGTFDWPAFAAAGVEVALGTDSVASGETLN----VREEVTFARQLY 375 Query: 355 INKVNEKSLTLKEVFRLATLGGSQALG 381 L + + R A GG + +G Sbjct: 376 ------PGLDPRVLVRAAVKGGQRVVG 396 >4F0L-A nrPDB Length = 458 Score = 42.7 bits (99), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 77/339 (22%), Positives = 124/339 (36%), Gaps = 47/339 (13%) Query: 75 MPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNI-------------DFAE 121 + G+ + H HA QY AG L + P+ F + + AE Sbjct: 58 VAGMANLHSHAFQYGMAG----------LAERRGPSADSFWSWREIMYKFALTMTPEQAE 107 Query: 122 EVYTRVVRRTLKNGTTTACYFATIHTDSSLL----LADITDKFGQRAFVGKVCMDLNDTF 177 V R+ L+ G T F +H D L+++ D+ A + + L F Sbjct: 108 AVALRLYVDMLEAGFTRVGEFHYLHHDCDGTPYANLSEMADRIAAAATTAGMGLTLLPVF 167 Query: 178 PEY--------KETTEESIKETERFVS--EMLQKNYSRVKPIVTPRFSLSCSETLMGELG 227 + E I + ERF E +K + V S EL Sbjct: 168 YAHSGFGGAAANEGQRRFINDPERFARLIEGCRKTLEGFEGAVLGVAPHSLRAVTPDELD 227 Query: 228 NIAKT-RDLHIQSHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAE 286 ++ + D + H++E EVE + S K + +T + + H ++S E Sbjct: 228 SVTQLLPDAPVHIHVAEQVKEVEDC--IAWSGKRPVEWLLDHQDVTARWCLIHATHMSDE 285 Query: 287 ELNVFHERGASIAHCPNSNLSLSSGFLNVLEVLKHEVKIGLGTD----VAGGYSYSMLDA 342 E + GA CP + +L G N E K G+G+D + G L+ Sbjct: 286 ETKHMAKAGAIAGLCPVTEANLGDGTFNATEFAAAGGKFGIGSDSNVLIGIGDELRQLEY 345 Query: 343 IRRAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALG 381 +R + +L NE S T + +F A LGG+ A+G Sbjct: 346 SQRLYHRARNVL--AANEGS-TGRALFDGAVLGGNIAMG 381 >1YRR-A nrPDB Length = 382 Score = 32.3 bits (72), Expect = 0.46, Method: Compositional matrix adjust. Identities = 18/60 (30%), Positives = 30/60 (50%), Gaps = 11/60 (18%) Query: 334 GYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGK 393 G S +M++ +R N V + L EV R+ATL ++A+G++ +G GK Sbjct: 308 GSSLTMIEGVR-----------NLVEHCGIALDEVLRMATLYPARAIGVEKRLGTLAAGK 356 >3IV8-A nrPDB Length = 381 Score = 32.0 bits (71), Expect = 0.56, Method: Compositional matrix adjust. Identities = 17/60 (28%), Positives = 32/60 (53%), Gaps = 11/60 (18%) Query: 333 GGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVG 392 GG + +M++A++ N V + L E R+ATL ++A+G+D ++G + G Sbjct: 307 GGSALTMIEAVQ-----------NTVEHVGIALDEALRMATLYPAKAIGVDEKLGRIKKG 355 >3MKV-A nrPDB Length = 426 Score = 30.8 bits (68), Expect = 1.2, Method: Compositional matrix adjust. Identities = 46/230 (20%), Positives = 89/230 (38%), Gaps = 31/230 (13%) Query: 186 ESIKETERFVSEMLQKNYSRVKPIVT--------PRFSLSCSETLMGELGNIAKTRDLHI 237 + + E R V E LQ ++K + + P SE + + A+ R ++ Sbjct: 172 DGVDEVRRAVREELQMGADQIKIMASGGVASPTDPVGVFGYSEDEIRAIVAEAQGRGTYV 231 Query: 238 QSHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEEL--NVFHERG 295 +H AV+ + ++ + D+ T + V HG Y+ + + G Sbjct: 232 LAHAYTPAAIARAVRCGVRTIEHGNLIDDE----TARLVAEHGAYVVPTLVTYDALASEG 287 Query: 296 ASIAHCPNSNLSLS---SGFLNVLEVLKHE-VKIGLGTDVAGGYSYSMLDAIRRAVMVSN 351 P S ++ L+ +E++K VK+G GTD+ G D R Sbjct: 288 EKYGLPPESIAKIADVHGAGLHSIEIMKRAGVKMGFGTDLLGEAQRLQSDEFR------- 340 Query: 352 ILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILIN 401 + + L+ EV AT+ ++ LG+ ++G G D ++++ Sbjct: 341 ------ILAEVLSPAEVIASATIVSAEVLGMQDKLGRIVPGAHADVLVVD 384 >2P9B-A nrPDB Length = 458 Score = 30.4 bits (67), Expect = 1.6, Method: Compositional matrix adjust. Identities = 15/40 (37%), Positives = 21/40 (52%) Query: 367 EVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASD 406 E AT + LG+D E G+ EVGK D +++N D Sbjct: 373 EALHAATAVNASILGVDAETGSLEVGKSADLLVLNANPLD 412 >3IEQ-A nrPDB Length = 183 Score = 30.0 bits (66), Expect = 2.3, Method: Compositional matrix adjust. Identities = 20/69 (28%), Positives = 32/69 (46%), Gaps = 2/69 (2%) Query: 122 EVYTRVVRRTLKNGTTTACYFATI--HTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPE 179 +V+ V R L G T Y + H+D+ +LL ITD A +G + +DT P Sbjct: 31 DVHQLVPGRPLIIGGVTIPYERGLLGHSDADVLLHAITDALFGAAALGDIGRHFSDTDPR 90 Query: 180 YKETTEESI 188 +K ++ Sbjct: 91 FKGADSRAL 99 >5XJN-A nrPDB Length = 455 Score = 29.6 bits (65), Expect = 2.7, Method: Compositional matrix adjust. Identities = 19/54 (35%), Positives = 24/54 (44%), Gaps = 4/54 (7%) Query: 137 TTACYFATIHTDSSLLLADITDK----FGQRAFVGKVCMDLNDTFPEYKETTEE 186 T A F H DS L D DK G + G D+++ FP YKE +E Sbjct: 21 TAAAKFERQHMDSPDLGTDDDDKAMADIGSTSHHGYQPFDMHNPFPAYKELRQE 74 >2XP1-A nrPDB Length = 178 Score = 28.1 bits (61), Expect = 7.7, Method: Compositional matrix adjust. Identities = 34/120 (28%), Positives = 49/120 (40%), Gaps = 16/120 (13%) Query: 95 IDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTACYFATIHTDSSLLLA 154 + + + E YT +H F++ID VY R + R LK+ A YF + LL + Sbjct: 59 VHMKIEEHSEHYTCSNKH-FEDIDEVISVYVRPILRNLKSIKAHAKYFNSPEDAEKLLSS 117 Query: 155 DITDK-----FGQRAFVGKVCMDLNDTFPEYKETTEESIKETERFVSEMLQKNYSRVKPI 209 K + R + GK+ N+ SI E VS+ML N S K I Sbjct: 118 FDGSKVVYAFYFSRKYPGKLTFAYNNG----------SILEEYIGVSDMLTYNNSTFKDI 167 >2XDQ-A nrPDB Length = 460 Score = 27.7 bits (60), Expect = 9.6, Method: Compositional matrix adjust. Identities = 22/71 (30%), Positives = 31/71 (43%), Gaps = 6/71 (8%) Query: 61 KPCEIRELSHHEFFMPGLVDTHI-HASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDF 119 KP +L + P LV T + HA+ G S +W ++TF H F N Sbjct: 380 KPDNYNQLQRIKALQPDLVITGMAHANPLEARGIST-----KWSVEFTFAQIHGFGNARD 434 Query: 120 AEEVYTRVVRR 130 E+ TR +RR Sbjct: 435 ILELVTRPLRR 445 >4WHB-E nrPDB Length = 461 Score = 27.7 bits (60), Expect = 9.8, Method: Compositional matrix adjust. Identities = 15/47 (31%), Positives = 25/47 (53%) Query: 360 EKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASD 406 EK ++ E AT+ ++A G +IG+ E GK D +L++ D Sbjct: 381 EKGMSPLEAISAATINVARAYGKADQIGSVETGKLADFVLLDQDPVD 427 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 3E0L-A nrPDB 609 e-175 2I9U-A nrPDB 395 e-110 3LNP-A nrPDB 384 e-107 4DYK-A nrPDB 379 e-105 2OOD-A nrPDB 363 e-101 4DZH-A nrPDB 361 e-100 4F0R-A nrPDB 354 5e-98 3HPA-A nrPDB 302 2e-82 4V1Y-A nrPDB 291 5e-79 2PLM-A nrPDB 283 1e-76 2PAJ-A nrPDB 261 5e-70 4LH8-A nrPDB 260 1e-69 4F0L-A nrPDB 229 2e-60 3V7P-A nrPDB 205 3e-53 2IMR-A nrPDB 194 6e-50 Sequences not found previously or not previously below threshold: 3MDW-A nrPDB 162 2e-40 2BB0-A nrPDB 84 2e-16 2P9B-A nrPDB 80 2e-15 3MKV-A nrPDB 80 3e-15 4CQD-A nrPDB 78 1e-14 2PUZ-A nrPDB 77 1e-14 2OOF-A nrPDB 76 3e-14 4WGX-A nrPDB 64 1e-10 1R9X-A nrPDB 63 3e-10 3N2C-A nrPDB 61 1e-09 3MTW-A nrPDB 60 2e-09 4WHB-E nrPDB 59 3e-09 4C65-A nrPDB 57 2e-08 2QS8-A nrPDB 54 1e-07 2OGJ-A nrPDB 49 4e-06 3OOQ-A nrPDB 49 5e-06 1XRT-A nrPDB 48 7e-06 1YRR-A nrPDB 44 1e-04 1NFG-A nrPDB 44 1e-04 6NBO-A nrPDB 43 2e-04 6AJD-A nrPDB 43 2e-04 3EWD-A nrPDB 43 2e-04 6II7-A nrPDB 42 4e-04 2AMX-A nrPDB 41 9e-04 2VUN-A nrPDB 41 0.001 3E74-A nrPDB 41 0.001 1YNY-A nrPDB 39 0.005 3IV8-A nrPDB 39 0.006 1GKQ-A nrPDB 38 0.012 3T8L-A nrPDB 36 0.025 4CEX-C nrPDB 36 0.029 2VHL-A nrPDB 36 0.030 5NKS-A nrPDB 36 0.036 3IGH-X nrPDB 36 0.040 4Z42-C nrPDB 35 0.068 3MPG-A nrPDB 34 0.097 1RK6-A nrPDB 34 0.12 5XGX-A nrPDB 34 0.14 4LCQ-A nrPDB 34 0.14 2ICS-A nrPDB 34 0.17 1E9Y-B nrPDB 33 0.25 4H9M-A nrPDB 33 0.28 3SFW-A nrPDB 33 0.33 3S9V-A nrPDB 33 0.40 4G7E-B nrPDB 33 0.41 3TAC-A nrPDB 33 0.44 4OTK-A nrPDB 32 0.58 1FWC-C nrPDB 32 0.70 3QGK-C nrPDB 32 0.75 4TQT-A nrPDB 31 0.92 1K1D-A nrPDB 31 0.93 6HAW-A nrPDB 31 1.3 3DC8-A nrPDB 31 1.3 6N91-A nrPDB 31 1.5 3R64-A nrPDB 30 1.8 1GKR-A nrPDB 30 1.9 4YHJ-A nrPDB 30 2.3 3CKY-A nrPDB 29 3.0 1C8N-A nrPDB 29 3.1 2VR2-A nrPDB 29 3.2 1SQH-A nrPDB 29 3.3 5NSQ-A nrPDB 29 3.9 3GIQ-A nrPDB 29 4.0 6D8G-A nrPDB 29 4.2 4OJZ-A nrPDB 29 5.2 1BEV-3 nrPDB 29 6.0 5YZA-A nrPDB 28 7.0 4NML-A nrPDB 28 7.8 >3E0L-A nrPDB Length = 455 Score = 609 bits (1571), Expect = e-175, Method: Composition-based stats. Identities = 448/454 (98%), Positives = 448/454 (98%), Gaps = 2/454 (0%) Query: 1 MCAAQMPPLAHIFRGTFVHSTWTCPMEVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCF 60 MCAAQMPPLAHIFRGTFVHSTWTCPMEVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCF Sbjct: 4 MCAAQMPPLAHIFRGTFVHSTWTCPMEVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCF 63 Query: 61 KPCEIRELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFA 120 KPCEIRELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFA Sbjct: 64 KPCEIRELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFA 123 Query: 121 EEVYTRVVRRTLKNGTTTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEY 180 EEVYTRVVRRTLKNGTTTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEY Sbjct: 124 EEVYTRVVRRTLKNGTTTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEY 183 Query: 181 KETTEESIKETERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSH 240 KETTEESIKETERFVSEMLQKNYSRVKPIVTP SETLMGELGNIAKTRDLHIQSH Sbjct: 184 KETTEESIKETERFVSEMLQKNYSRVKPIVTP--GNGVSETLMGELGNIAKTRDLHIQSH 241 Query: 241 ISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAH 300 ISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAH Sbjct: 242 ISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAH 301 Query: 301 CPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNE 360 CPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNE Sbjct: 302 CPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNE 361 Query: 361 KSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDSPIDLFYGDFFGDI 420 KSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDSPIDLFYGDFFGDI Sbjct: 362 KSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDSPIDLFYGDFFGDI 421 Query: 421 SEAVIQKFLYLGDDRNIEEVYVGGKQVVPFSSSV 454 SEAVIQKFLYLGDDRNIEEVYVGGKQVVPFSSSV Sbjct: 422 SEAVIQKFLYLGDDRNIEEVYVGGKQVVPFSSSV 455 >2I9U-A nrPDB Length = 439 Score = 395 bits (1014), Expect = e-110, Method: Composition-based stats. Identities = 162/439 (36%), Positives = 244/439 (55%), Gaps = 27/439 (6%) Query: 12 IFRGTFVHSTWTCPMEVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHH 71 IF+G + + + +++D + V D GKI AS L ++ P + Sbjct: 12 IFKGNLIFTKTSDKFTIMKDSYIVVID-GKI-----ASVSSNLPDKYKGNPI---IDFRN 62 Query: 72 EFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRT 131 +PG+ D H HASQY G +D LL WL YTFP E +F N+D+A++ Y R+++ Sbjct: 63 NIIIPGMNDLHAHASQYKNLGIGMDKELLPWLNNYTFPEEAKFLNVDYAKKTYGRLIKDL 122 Query: 132 LKNGTTTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEY-KETTEESIKE 190 +KNGTT FAT+H DS++ L ++ K G A+VGKV MD N P+Y E S+ + Sbjct: 123 IKNGTTRVALFATLHKDSTIELFNMLIKSGIGAYVGKVNMDYN--CPDYLTENYITSLND 180 Query: 191 TERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEA 250 TE + + K+ + VKPI+TPRF SCS LM LG ++ L +QSH+SEN DE+ Sbjct: 181 TEEIILKYKDKS-NIVKPIITPRFVPSCSNELMDGLGKLSYKYRLPVQSHLSENLDEIAV 239 Query: 251 VKNLYPSYKNYTSVYDKNNLLTNK-TVMAHGCYLSAEELNVFHERGASIAHCPNSNLSLS 309 VK+L+ Y VYDK L N T+MAH + S EE+N+ +I HCP SN +L Sbjct: 240 VKSLHKKSNFYGEVYDKFGLFGNTPTLMAHCIHSSKEEINLIKRNNVTIVHCPTSNFNLG 299 Query: 310 SGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNEKS-LTLKEV 368 SG + V + L + + LG+D++ G++ S+ I A+ S I + L+ E Sbjct: 300 SGMMPVRKYLNLGINVVLGSDISAGHTCSLFKVIAYAIQNSKIKWQESGKKDMFLSTSEA 359 Query: 369 FRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDSPIDLFYGDFFGDISEAVIQKF 428 F +AT G G ++G+FE G +FDA++IN +L+ D+ D++E +++F Sbjct: 360 FYMATKKGGSFFG---KVGSFEEGYDFDALVINDS------NLYPEDY--DLTER-LERF 407 Query: 429 LYLGDDRNIEEVYVGGKQV 447 +YLGDDRNI + YV G ++ Sbjct: 408 IYLGDDRNIMKRYVCGNEI 426 >3LNP-A nrPDB Length = 468 Score = 384 bits (986), Expect = e-107, Method: Composition-based stats. Identities = 116/463 (25%), Positives = 196/463 (42%), Gaps = 58/463 (12%) Query: 5 QMPPLAHIFRGTFVHSTWTCPME----------VLRDHLLGVSDSGKIVFLEEASQQEKL 54 Q P AH ++S W P+E +L DH L + D G I+ +E S Sbjct: 16 QSQPKAH--ADLRINSHWIIPIENTTDHNLVSNILIDHCLLIKD-GIILAIEPQS----- 67 Query: 55 AKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRF 114 C P + MPG V+ H HA+ F G + DLPL+ WL ++ +PAE + Sbjct: 68 ---SCQIPATETLDLGQQVLMPGWVNAHGHAAMSLFRGLADDLPLMTWLQEHVWPAEAQH 124 Query: 115 QNIDFAEEVYTRVVRRTLKNGTTTAC--YFATIHTDSSLLLADITDKFGQRAFVGKVCMD 172 + F ++ + +++GTTT YF + + L A G RA +D Sbjct: 125 VDEHFVKQGTELAIAEMIQSGTTTFADMYFYPQQSGEAALAA------GIRAVCFAPVLD 178 Query: 173 LNDTFP-EYKETTEESIKET----ERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELG 227 FP Y + +E I++ +RF + + + V+ P + S+ + E+ Sbjct: 179 ----FPTNYAQNADEYIRKAIECNDRFNNHPMNEQ-GLVQIGFGPHAPYTVSDEPLKEIT 233 Query: 228 NIAKTRDLHIQSHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEE 287 ++ D+ +Q H+ E EV ++L K T L + H + + Sbjct: 234 MLSDQLDMPVQIHLHETDFEVS--ESLETFNKRPTQRLADIGFLNERVSCVHMTQVDDGD 291 Query: 288 LNVFHERGASIAHCPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAV 347 + + + GASI HCP SNL L+SGF + ++ + + +GTD G S + LD Sbjct: 292 IKILQKTGASIIHCPESNLKLASGFCPIAKLSAANIPLAIGTD--GAASNNDLDMFSETK 349 Query: 348 MVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFD--AILINPKAS 405 + + + ++ E +ATLGG++ALG+D G+ + GK D AI +N +S Sbjct: 350 TAALLAKGVSQDASAIPAIEALTMATLGGARALGIDDITGSLKPGKAADIQAIDLNTLSS 409 Query: 406 DSPIDLFYGDFFGDISEAVIQKFLYLGDDRNIEEVYVGGKQVV 448 D + +Y + V+V G+ ++ Sbjct: 410 QPVFD-------------PVSHMVYCTKSTQVSHVWVNGRCLL 439 >4DYK-A nrPDB Length = 451 Score = 379 bits (974), Expect = e-105, Method: Composition-based stats. Identities = 112/439 (25%), Positives = 197/439 (44%), Gaps = 42/439 (9%) Query: 17 FVHSTWTCPME----VLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHE 72 + TW P+E VLRDH LG+ D G+I + Q + EIREL Sbjct: 11 LLLPTWIVPVEPAGVVLRDHALGIRD-GQIALVAPREQAMR------HGATEIRELPGM- 62 Query: 73 FFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTL 132 PGLV+ H H++ F G + DLPL+ WL + +PAE ++ + DF + + + Sbjct: 63 LLAPGLVNAHGHSAMSLFRGLADDLPLMTWLQDHIWPAEGQWVSEDFIRDGTELAIAEQV 122 Query: 133 KNGTTTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESIKETE 192 K G T F+ ++ + + D G RA V +D P +++ E+I++ Sbjct: 123 KGGITC---FSDMYFYPQAICGVVHDS-GVRAQVAIPVLDF--PIPGARDSA-EAIRQGM 175 Query: 193 RFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVK 252 ++ K++ R++ P + S+ + ++ + + D IQ H+ E EVE + Sbjct: 176 ALFDDL--KHHPRIRIAFGPHAPYTVSDDKLEQILVLTEELDASIQMHVHETAFEVE--Q 231 Query: 253 NLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAHCPNSNLSLSSGF 312 + + + + + LL + H + ++L + E +S+ HCP SNL L+SGF Sbjct: 232 AMERNGERPLARLHRLGLLGPRFQAVHMTQVDNDDLAMLVETNSSVIHCPESNLKLASGF 291 Query: 313 LNVLEVLKHEVKIGLGTD-VAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRL 371 V ++ + V + +GTD A +L R A +++ + +L R+ Sbjct: 292 CPVEKLWQAGVNVAIGTDGAASNNDLDLLGETRTAALLAKAVYGQA---TALDAHRALRM 348 Query: 372 ATLGGSQALGLDGEIGNFEVGKEFDAILINPKAS--DSPIDLFYGDFFGDISEAVIQKFL 429 ATL G++ALGL+ IG+ E GK D + + D + + + Sbjct: 349 ATLNGARALGLERLIGSLEAGKAADLVAFDLSGLAQQPVYD-------------PVSQLI 395 Query: 430 YLGDDRNIEEVYVGGKQVV 448 Y + V+VGG+Q++ Sbjct: 396 YASGRDCVRHVWVGGRQLL 414 >2OOD-A nrPDB Length = 475 Score = 363 bits (932), Expect = e-101, Method: Composition-based stats. Identities = 126/441 (28%), Positives = 199/441 (45%), Gaps = 34/441 (7%) Query: 30 RDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQYS 89 +D L+ V+D G I + P +PG +D HIH Q Sbjct: 34 QDGLMVVTD-GVIKAFGPYEKIAAAH------PGVEITHIKDRIIVPGFIDGHIHLPQTR 86 Query: 90 FAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTACYFATIHTDS 149 G+ + LL WL K +P E ++++ ++A E R + L GTTT F + + Sbjct: 87 VLGAYGE-QLLPWLQKSIYPEEIKYKDRNYAREGVKRFLDALLAAGTTTCQAFTSSSPVA 145 Query: 150 SLLLADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESIKETERFVSEMLQKNYSRVKPI 209 + L + + R G +D N E+ +T E ++++R +++ K R Sbjct: 146 TEELFEEASRRNMRVIAGLTGIDRNAP-AEFIDTPENFYRDSKRLIAQYHDK--GRNLYA 202 Query: 210 VTPRFSLSCSETLMGELGNIAKTR-DLHIQSHISENRDEVEAVKNLYPSYKNYTSVYDKN 268 +TPRF+ S L+ + D + +HISEN E V +P ++Y VY+K Sbjct: 203 ITPRFAFGASPELLKACQRLKHEHPDCWVNTHISENPAECSGVLVEHPDCQDYLGVYEKF 262 Query: 269 NLLTNKTVMAHGCYLSAEELNVFHERGASIAHCPNSNLSLSSGFLNVLEVLK--HEVKIG 326 +L+ K HG YLS E ++GA++ CP SNL L SG + H VK+ Sbjct: 263 DLVGPKFSGGHGVYLSNNEFRRMSKKGAAVVFCPCSNLFLGSGLFRLGRATDPEHRVKMS 322 Query: 327 LGTDVAGGYSYSM---LDAIRRAVMVSNILLINKVNEKSLTLKEV----------FRLAT 373 GTDV GG +SM LD + M +N LL ++ L E F T Sbjct: 323 FGTDVGGGNRFSMISVLDDAYKVGMCNNTLLDGSIDPSRKDLAEAERNKLSPYRGFWSVT 382 Query: 374 LGGSQALGLDGEIGNFEVGKEFDAILINPKAS-------DSPIDLFYGDFFGDISEAVIQ 426 LGG++ L +D ++GNFE GKE D + ++P S I G D + +++ Sbjct: 383 LGGAEGLYIDDKLGNFEPGKEADFVALDPNGGQLAQPWHQSLIADGAGPRTVDEAASMLF 442 Query: 427 KFLYLGDDRNIEEVYVGGKQV 447 + +GDDR ++E +V GK++ Sbjct: 443 AVMMVGDDRCVDETWVMGKRL 463 >4DZH-A nrPDB Length = 472 Score = 361 bits (926), Expect = e-100, Method: Composition-based stats. Identities = 109/441 (24%), Positives = 182/441 (41%), Gaps = 51/441 (11%) Query: 17 FVHSTWTCPME----VLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHE 72 + + + P+E VL DH + VS+ + L A + + F P Sbjct: 17 LIEAGYVVPIEPHAVVLEDHAVAVSNGVIVAVLPTADARVR------FAPARTVSRP-DA 69 Query: 73 FFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTL 132 MPGLV+ H H G + DLPL+ WL ++ +P E +F + T + L Sbjct: 70 ALMPGLVNAHTHNPMTLLRGVADDLPLMVWLQQHIWPVEAAVIGPEFVADGTTLAIAEML 129 Query: 133 KNGTTTAC---YFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESIK 189 + GTT +FA + A + + G RA VG V +D FP T + Sbjct: 130 RGGTTCVNENYFFADVQ-------AAVYKQHGFRALVGAVIID----FP-----TAWASS 173 Query: 190 ETERFVSEMLQKNYSRVKP----IVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENR 245 + E F + R P P + ++ + +A D+ + H E Sbjct: 174 DDEYFARAGELHDQWRDDPLISTAFAPHAPYTVNDANFERVRMLADQLDMPVHLHTHETA 233 Query: 246 DEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAHCPNSN 305 EV Y + + D+ L+ ++ + H L+ E+++ ERG S+ HCP SN Sbjct: 234 QEVADSVAQY--GQRPLARLDRLGLVNDRLIAVHMTQLTEAEIHLCAERGVSVVHCPESN 291 Query: 306 LSLSSGFLNVLEVLKHEVKIGLGTD-VAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLT 364 L L+SGF + + V + +GTD A M R A +++ + + +L Sbjct: 292 LKLASGFCPACALQRASVNLAIGTDGCASNNDLDMFSENRTAAILAKAV---ANDATALD 348 Query: 365 LKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDSPIDLFYGDFFGDISEAV 424 R ATLGG++ALG IG+ EVGK+ D + ++ A ++ V Sbjct: 349 AATTLRAATLGGARALGFGDRIGSIEVGKQADLVCVDLSALET-----------QPLHHV 397 Query: 425 IQKFLYLGDDRNIEEVYVGGK 445 + + +Y + +V++ GK Sbjct: 398 LSQLIYAAGRHQVTDVWIAGK 418 >4F0R-A nrPDB Length = 447 Score = 354 bits (907), Expect = 5e-98, Method: Composition-based stats. Identities = 106/438 (24%), Positives = 194/438 (44%), Gaps = 40/438 (9%) Query: 17 FVHSTWTCPME----VLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHE 72 + + W +E VL +H + + D GKI + A+ L + E EL H Sbjct: 9 IISARWIITVETDGEVLENHAIAIRD-GKIAAIIPAADAAGLEAD------ERLELPDH- 60 Query: 73 FFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTL 132 MPGL++ H H++ G + D L++WLT Y +P E + + DF + + + Sbjct: 61 VLMPGLINLHGHSAMSLLRGLADDKALMDWLTNYIWPTEGKHVHDDFVFDGSLLAMGEMI 120 Query: 133 KNGTTTA--CYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESIKE 190 + GTTT YF + L + G R FVG ++ Y ++ I + Sbjct: 121 RGGTTTINDMYFYNAAVARAGLAS------GMRTFVGCSILEFPT---NYASNADDYIAK 171 Query: 191 TERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEA 250 S+ L ++ + + P + S+ ++ +A+ D+ I HI E DEV Sbjct: 172 GMAERSQFLGEDL--LTFTLAPHAPYTVSDDTFRKVVTLAEQEDMLIHCHIHETADEVN- 228 Query: 251 VKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAHCPNSNLSLSS 310 ++ + + + LL+ + V AH +L+ E+ + G S AH P SN+ L+S Sbjct: 229 -NSVKEHGQRPLARLQRLGLLSPRLVAAHMVHLNDAEVELAARHGLSTAHNPASNMKLAS 287 Query: 311 GFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFR 370 G V +++ V +G+GTD G S + LD + + + + + ++ S+ R Sbjct: 288 GISPVSKLMDAGVAVGIGTD--GAASNNKLDMLAETRLAALLAKVGTLDPTSVPAAAAIR 345 Query: 371 LATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDSPIDLFYGDFFGDISEAVIQKFLY 430 +ATL G++ALG+ ++G+ +VGK+ D I ++ ++ I +Y Sbjct: 346 MATLNGARALGIADKVGSVKVGKQADLIALDLAQLETAPAF-----------DPISHVVY 394 Query: 431 LGDDRNIEEVYVGGKQVV 448 + V+V G+ ++ Sbjct: 395 AAGREQVSHVWVKGRALM 412 >3HPA-A nrPDB Length = 479 Score = 302 bits (774), Expect = 2e-82, Method: Composition-based stats. Identities = 94/432 (21%), Positives = 174/432 (40%), Gaps = 42/432 (9%) Query: 29 LRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQY 88 LRD L + D+ +IV + +++ + A E+ +L H +PGLV+TH H Q Sbjct: 49 LRDAGLYIEDN-RIVAVGPSAELPETAD-------EVLDLRGH-LVIPGLVNTHHHMYQS 99 Query: 89 SFA--GSSIDLPLLEWLTK-YTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTACYFATI 145 ++ + L WLT Y A + I+ + + L++G TT+ I Sbjct: 100 LTRAVPAAQNAELFGWLTNLYKIWAHLTPEMIEVS---TLTAMAELLQSGCTTSSDHLYI 156 Query: 146 HTDSSLLLADI--TDKFGQRAFVGKVCMDLNDTFPE-----YKETTEESIKETERFVSEM 198 + + S L I + G R + M + E + +++T+R + Sbjct: 157 YPNGSRLDDSIGAAQRIGMRFHASRGAMSVGQRDGGLPPDSVVEREPDILRDTQRLIETY 216 Query: 199 LQK-NYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKNLYPS 257 + Y+ ++ +V P S S LM + +A+ + + +H++EN +++ + Sbjct: 217 HDEGRYAMLRVVVAPCSPFSVSRDLMRDAAVLAREYGVSLHTHLAENVNDIAYSR--EKF 274 Query: 258 YKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAHCPNSNLSLSSGFLNVLE 317 + + + AH L + +F G +AHCP SN+ L+SG V + Sbjct: 275 GMTPAEYAEDLGWVGHDVWHAHCVQLDDAGIGLFARTGTGVAHCPCSNMRLASGIAPVKK 334 Query: 318 VLKHEVKIGLGTD-VAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATLGG 376 + V +GLG D A M+ +R+A+++ + ++T +E +ATLGG Sbjct: 335 MRLAGVPVGLGVDGSASNDGAQMVAEVRQALLLQRV----GFGPDAMTAREALEIATLGG 390 Query: 377 SQALGLDGEIGNFEVGKEFDAILINPKASDSPIDLFYGDFFGDISEAVIQKFLYLGDDRN 436 ++ L D IG + G D + + F + ++ Sbjct: 391 AKVLNRDD-IGALKPGMAADFAAFDLR----------QPLFAGALHDPVAALVFCAPS-Q 438 Query: 437 IEEVYVGGKQVV 448 V GK VV Sbjct: 439 TAYTVVNGKVVV 450 >4V1Y-A nrPDB Length = 494 Score = 291 bits (744), Expect = 5e-79, Method: Composition-based stats. Identities = 88/403 (21%), Positives = 165/403 (40%), Gaps = 41/403 (10%) Query: 27 EVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHAS 86 VL D + V D G+IV L + E P + + + +PG ++ H H + Sbjct: 39 RVLGDSWVHVQD-GRIVAL-------GVHAESVPPPADRVIDARGKVVLPGFINAHTHVN 90 Query: 87 QYSFAG-SSIDLPLLEWLTKYTFPAEH--RFQNIDFAEEVYTRVVRRTLKNGTTTACYFA 143 Q G S +WL +P + R +++ A +Y +++G TT A Sbjct: 91 QILLRGGPSHGRQFYDWLFNVVYPGQKAMRPEDVAVAVRLYC---AEAVRSGITTINENA 147 Query: 144 T--IHTDSSLLLADITDKFGQRAFVGKVCMD------------LNDTFPEYK--ETTEES 187 I+ + + + G R ++ D L P+ + EE+ Sbjct: 148 DSAIYPGNIEAAMAVYGEVGVRVVYARMFFDRMDGRIQGYVDALKARSPQVELCSIMEET 207 Query: 188 IKETERFVS---EMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISEN 244 +R + + R+ P + + + M A+ R + H++E+ Sbjct: 208 AVAKDRITALSDQYHGTAGGRISVWPAPATTTAVTVEGMRWAQAFARDRAVMWTLHMAES 267 Query: 245 RDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAHCPNS 304 D E + + P+ Y Y LL + +AH Y +++ + H +A S Sbjct: 268 -DHDERIHGMSPA--EYMECY---GLLDERLQVAHCVYFDRKDVRLLHRHNVKVASQVVS 321 Query: 305 NLSLSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLT 364 N L SG V E+++ + +G+GTD G S ++ I +++I + LT Sbjct: 322 NAYLGSGVAPVPEMVERGMAVGIGTD--NGNSNDSVNMIGDMKFMAHIHRAVHRDADVLT 379 Query: 365 LKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDS 407 +++ +AT+ G+++LG+D EIG+ E GK D IL++ + + Sbjct: 380 PEKILEMATIDGARSLGMDHEIGSIETGKRADLILLDLRHPQT 422 >2PLM-A nrPDB Length = 406 Score = 283 bits (723), Expect = 1e-76, Method: Composition-based stats. Identities = 85/408 (20%), Positives = 149/408 (36%), Gaps = 36/408 (8%) Query: 33 LLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQYSFAG 92 L + D F + K ++ + MP L +TH HA G Sbjct: 6 CLILKDFSSEPFWGAVEIENGTIKRVLQGEVKVDLDLSGKLVMPALFNTHTHAPMTLLRG 65 Query: 93 SSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTACYFATIHTDSSLL 152 + DL EWL P E R + Y + ++ F ++ + Sbjct: 66 VAEDLSFEEWLFSKVLPIEDRLTE----KMAYYGTILAQMEMARHGIAGFVDMYFHEEWI 121 Query: 153 LADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESIKETERFVSEMLQKNYSRVKPIVTP 212 + D FG RA + + +D N E + E F R+ P Sbjct: 122 AKAVRD-FGMRALLTRGLVDSNGDDGGRLEENLKLYNEWNGF--------EGRIFVGFGP 172 Query: 213 RFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLT 272 CSE + + + AK+ + + H+ E E ++++ L Sbjct: 173 HSPYLCSEEYLKRVFDTAKSLNAPVTIHLYETSKEEYDLEDI-----------LNIGLKE 221 Query: 273 NKTVMAHGCYLSAEELNVFHERGASIAHCPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVA 332 KT+ AH +L V + ++H P SNL L +G V +++H +K+ LGTD Sbjct: 222 VKTIAAHCVHLPERYFGVLKDIPFFVSHNPASNLKLGNGIAPVQRMIEHGMKVTLGTD-- 279 Query: 333 GGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVG 392 G S + L+ + S LL N ++L + ++ T G+QA+G G E G Sbjct: 280 GAASNNSLNLFFEMRLAS--LLQKAQNPRNLDVNTCLKMVTYDGAQAMGFKS--GKIEEG 335 Query: 393 KEFDAILINPK-----ASDSPIDLFYGDFFGDISEAVIQ-KFLYLGDD 434 D ++I+ + + F G++ ++ K++Y + Sbjct: 336 WNADLVVIDLDLPEMFPVQNIKNHLVHAFSGEVFATMVAGKWIYFDGE 383 >2PAJ-A nrPDB Length = 492 Score = 261 bits (666), Expect = 5e-70, Method: Composition-based stats. Identities = 91/418 (21%), Positives = 156/418 (37%), Gaps = 46/418 (11%) Query: 60 FKPCEIRELSHHEFFMPGLVDTHIHASQYSFAG--SSIDLPLLEWLTKYTFPAEHRFQNI 117 +P E + P V+TH H Q G + +D L WL + F Sbjct: 54 PRPGETIVDATDCVIYPAWVNTHHHLFQSLLKGEPAGLDATLTPWLAATPYRFRALFDER 113 Query: 118 DFAEEVYTRVVRRTLKNGTTTAC-----YFATIHTDSSLLLADITDKFGQRAFV----GK 168 F + ++G T Y+ + DSS +L + +K G R + Sbjct: 114 RF-RLAARIGLIELARSGCATVADHNYVYYPGMPFDSSAILFEEAEKLGLRFVLLRGGAT 172 Query: 169 VCMDLNDTFPE--YKETTEESIKETERFVSEMLQKNYSRVKPIVTPRFS--LSCSETLMG 224 L P ET + + + ER + + ++ +V + S S M Sbjct: 173 QTRQLEADLPTALRPETLDAYVADIERLAARYHDASPRAMRRVVMAPTTVLYSISPREMR 232 Query: 225 ELGNIAKTRDLHIQSHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLS 284 E +A+ L + SH+SE ++ ++Y K+ + +++ L + AH + Sbjct: 233 ETAAVARRLGLRMHSHLSETVGYQDSAYSMY--GKSPVAFCGEHDWLGSDVWYAHLVKVD 290 Query: 285 AEELNVFHERGASIAHCPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIR 344 A+E+ + + G +AHCP SN L SG V E+ V + +G D G S D I Sbjct: 291 ADEIALLAQTGTGVAHCPQSNGRLGSGICPVREMADAGVPVSIGVD--GAASNEAADMIS 348 Query: 345 RAVM-----VSNILLINKVNEK---------SLTLKEVFRLATLGGSQALGLDGEIGNFE 390 M + + ++ + + + ++ EV T GG++ +GLD E+G Sbjct: 349 EVHMTWLAQRARLGMLAQPAYRGGSFEGGAGAASIAEVIHWGTAGGARVMGLD-EVGKVA 407 Query: 391 VGKEFDAILINPKASDSPIDLFYGDFFGDISEAVIQKFLYLGDDRNIEEVYVGGKQVV 448 VG D A D Y V G ++ ++ GK+VV Sbjct: 408 VGYAADI------AVYRLDDPRYFGLHDPAIGPVAS-----GGRPSVMALFSAGKRVV 454 >4LH8-A nrPDB Length = 469 Score = 260 bits (663), Expect = 1e-69, Method: Composition-based stats. Identities = 92/461 (19%), Positives = 160/461 (34%), Gaps = 56/461 (12%) Query: 12 IFRGTFVHSTWTCPMEVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHH 71 + RG T+ L D + + D KIV + K + Sbjct: 16 LIRGLTRVITFDDQERELEDADILI-DGPKIVAVG---------KNLSDRSVSRTIDGRG 65 Query: 72 EFFMPGLVDTHIHASQYSFAGSSIDLPLLE------WLTKYTFPAEHRFQNIDFAEEVYT 125 +PGL+++H Q+ + G+ +P LE WL + +++ F +V Sbjct: 66 MIALPGLINSH----QHLYEGAMRAIPQLERVTMASWLEGVLTRSAGWWRDGKFGPDVIR 121 Query: 126 RVVR----RTLKNGTTTAC----YFATIHTDSSL-LLADITDKFGQRAFVGKVCMDLNDT 176 V R +L G TT +F DS + + G R + M L + Sbjct: 122 EVARAVLLESLLGGITTVADQHPFFPGATADSYIDATIEAATDLGIRFHAVRSSMTLGKS 181 Query: 177 FPEYKETTEESIKETERFVSEMLQ--------KNYSRVKPIVTPRFSLSCSETLMGELGN 228 E + ++ +R V L + + V+ + P L Sbjct: 182 --EGGFCDDLFVEPVDRVVQHCLGLIDQYHEPEPFGMVRIALGPCGVPYDKPELFEAFAQ 239 Query: 229 IAKTRDLHIQSHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEEL 288 +A D+ + +H E D +LY +K+ +++ +AH EE+ Sbjct: 240 MAADYDVRLHTHFYEPLD-AGMSDHLY--GMTPWRFLEKHGWASDRVWLAHAVVPPREEI 296 Query: 289 NVFHERGASIAHCPNSNLSLSSGFLNVLEVLKHEVKIGLG-TDVAGGYSYSMLDAIRRAV 347 F + G +IAH +L + G + E L + +G G T A ++L +R A Sbjct: 297 PEFADAGVAIAHLIAPDLRMGWGLAPIREYLDAGITVGFGTTGSASNDGGNLLGDLRLAA 356 Query: 348 MVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDS 407 + N+ EK L+ +E+ R+AT G ++ LG +G E G+ D D Sbjct: 357 LAHRPADPNE-PEKWLSARELLRMATRGSAECLGRPD-LGVLEEGRAADIACWRLDGVDR 414 Query: 408 PIDLFYGDFFGDISEAVIQKFLYLGDDRNIEEVYVGGKQVV 448 + G V V G+ +V Sbjct: 415 V-----------GVHDPAIGLIMTGLSDRASLVVVNGQVLV 444 >4F0L-A nrPDB Length = 458 Score = 229 bits (583), Expect = 2e-60, Method: Composition-based stats. Identities = 81/410 (19%), Positives = 143/410 (34%), Gaps = 61/410 (14%) Query: 67 ELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNI--------- 117 + + G+ + H HA QY AG L + P+ F + Sbjct: 50 DDERQSVVVAGMANLHSHAFQYGMAG----------LAERRGPSADSFWSWREIMYKFAL 99 Query: 118 ----DFAEEVYTRVVRRTLKNGTTTACYFATIHTDSSLL----LADITDKFGQRAFVGKV 169 + AE V R+ L+ G T F +H D L+++ D+ A + Sbjct: 100 TMTPEQAEAVALRLYVDMLEAGFTRVGEFHYLHHDCDGTPYANLSEMADRIAAAATTAGM 159 Query: 170 CMDLNDTFPEY--------KETTEESIKETERFVS--EMLQKNYSRVKPIVTPRFSLSCS 219 + L F + E I + ERF E +K + V S Sbjct: 160 GLTLLPVFYAHSGFGGAAANEGQRRFINDPERFARLIEGCRKTLEGFEGAVLGVAPHSLR 219 Query: 220 ETLMGELGNIAKTR-DLHIQSHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMA 278 EL ++ + D + H++E EVE + S K + +T + + Sbjct: 220 AVTPDELDSVTQLLPDAPVHIHVAEQVKEVEDC--IAWSGKRPVEWLLDHQDVTARWCLI 277 Query: 279 HGCYLSAEELNVFHERGASIAHCPNSNLSLSSGFLNVLEVLKHEVKIGLGTD----VAGG 334 H ++S EE + GA CP + +L G N E K G+G+D + G Sbjct: 278 HATHMSDEETKHMAKAGAIAGLCPVTEANLGDGTFNATEFAAAGGKFGIGSDSNVLIGIG 337 Query: 335 YSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKE 394 L+ +R + +L + T + +F A LGG+ A+G + + G Sbjct: 338 DELRQLEYSQRLYHRARNVLAAN---EGSTGRALFDGAVLGGNIAMGRPED--GLKKGAS 392 Query: 395 FDAILINPKASDSPIDLFYGDFFGDISEAVIQKFLYLGDDRNIEEVYVGG 444 D + ++ + V+ +++ G + +V+V G Sbjct: 393 ADFVSLDVERLPHAKGDV-----------VLDGWIFAGRAH-VCDVWVRG 430 >3V7P-A nrPDB Length = 427 Score = 205 bits (521), Expect = 3e-53, Method: Composition-based stats. Identities = 87/431 (20%), Positives = 151/431 (35%), Gaps = 53/431 (12%) Query: 25 PMEVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIH 84 P +++D + KI ++ K P E + +PG + H+H Sbjct: 12 PQTIIQDKAVAF--DKKIEAIDTVENLIKKY------PNAAVEHDENSLLLPGFANPHLH 63 Query: 85 ASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTR--VVRRTLKNGTTTACYF 142 + + + WL HR +++ + + ++ GTT Sbjct: 64 LEFSANKATLQYGDFIPWLYSVI---RHR-EDLLPLCDGACLEQTLSSIIQTGTTAIGAI 119 Query: 143 ATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESIKETERFVSEMLQKN 202 + S + + N + ERF +N Sbjct: 120 S-----SYGEDLQACIDSALKVVYFNEVIGSNAATADVM-----YASFLERFHQSKKHEN 169 Query: 203 YSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKN-------LY 255 R K V S L +IAK + H E+R E E + + Sbjct: 170 -ERFKAAVAIHSPYSVHYILAKRALDIAKKYGSLVSVHFMESRAEREWLDKGSGEFAKFF 228 Query: 256 PSYKNYTS-VYDKNNLLTN----KTVMAHGCYLSAEELNVFHERGASIAHCPNSNLSLSS 310 + N T V D + L T+ H + + EE+ A I HCP SN L + Sbjct: 229 KEFLNQTRPVNDTKSFLELFKELHTLFVHMVWANEEEIQTIASYNAHIIHCPISNRLLGN 288 Query: 311 GFLNVLEVLKHEVKIGLGTD-VAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVF 369 G L++ ++ + + TD ++ YS +M + ++ A L ++ E + KE+ Sbjct: 289 GVLDLEKI--KSIPYAIATDGLSSNYSLNMYEELKAA------LFVHPNKEATTFAKELI 340 Query: 370 RLATLGGSQALGLDGEIGNFEVGKEFDAILIN-PKASDSPIDLFYGDFFGDISEAVIQKF 428 AT G ALG +G G VGK+ D LI+ P+ + DL+ I K Sbjct: 341 IRATKAGYDALGFEG--GEIAVGKDADMQLIDLPEGLTNVEDLY----LHVILHTTKPKK 394 Query: 429 LYLGDDRNIEE 439 +Y+ + ++ E Sbjct: 395 VYIQGEEHVRE 405 >2IMR-A nrPDB Length = 420 Score = 194 bits (493), Expect = 6e-50, Method: Composition-based stats. Identities = 68/355 (19%), Positives = 125/355 (35%), Gaps = 54/355 (15%) Query: 53 KLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEH 112 E + E P V+ H H ++ LP +W+ + H Sbjct: 70 GHPDELRRQYPHAAEERAGAVIAPPPVNAHTHLDMSAYE--FQALPYFQWIPEVVIRGRH 127 Query: 113 RFQNIDFAEEVYTRVVRRTLKNGTTTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMD 172 + + A+ + R L G +A D+ L D++ G + + Sbjct: 128 -LRGVAAAQAGADTLTR--LGAGGVGDIVWAPEVMDALLAREDLS---------GTLYFE 175 Query: 173 LNDTFPE-YKETTEESIKETERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAK 231 + + FP+ E + ER+ L++ R+ ++P + S LM L + A Sbjct: 176 VLNPFPDKADEVFAAARTHLERW--RRLERPGLRL--GLSPHTPFTVSHRLMRLLSDYAA 231 Query: 232 TRDLHIQSHISENRDEVEAVKN------------LYPSYK------------NYTSVYDK 267 L +Q H++E+ E+E + LYP D+ Sbjct: 232 GEGLPLQIHVAEHPTELEMFRTGGGPLWDNRMPALYPHTLAEVIGREPGPDLTPVRYLDE 291 Query: 268 NNLLTNKTVMAHGCYLSAEELNVFHERGASIAHCPNSNLSLSSGFLNVLEVLKHEVKIGL 327 +L + + H ++ +++ G ++ CP SN L G + V++ L Sbjct: 292 LGVLAARPTLVHMVNVTPDDIARVARAGCAVVTCPRSNHHLECGTFDWPAFAAAGVEVAL 351 Query: 328 GTD-VAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALG 381 GTD VA G + + +R V + L L + + R A GG + +G Sbjct: 352 GTDSVASGETLN----VREEVTFARQLYP------GLDPRVLVRAAVKGGQRVVG 396 >3MDW-A nrPDB Length = 453 Score = 162 bits (410), Expect = 2e-40, Method: Composition-based stats. Identities = 77/403 (19%), Positives = 158/403 (39%), Gaps = 43/403 (10%) Query: 71 HEFFMPGLVDTHIHASQYSFAGSSI-----DLPLLEWLTKYTFPAEHRFQNIDFAEEVYT 125 +PG+ + H HA Q + AG + + W + + R + + E + Sbjct: 45 GGAVLPGMPNLHSHAFQRAMAGLAEVAGNPNDSFWTW-RELMYRMVARL-SPEQIEVIAC 102 Query: 126 RVVRRTLKNGTTTACYFATIHTD----SSLLLADITDKFGQRAFVGKVCMDLNDTFPEYK 181 ++ LK G T F +H D S A+++ + + A + + L + Sbjct: 103 QLYIEMLKAGYTAVAEFHYVHHDLDGRSYADPAELSLRISRAASAAGIGLTLLPVLYSHA 162 Query: 182 --------ETTEESIKETERFVS--EMLQKNYSRVKPIVTPRFSLSCSETLMGELGNI-- 229 E I +E ++ + L+ + F S ++ + Sbjct: 163 GFGGQPASEGQRRFINGSEAYLELLQRLRAPLEAAGHSLGLCF-HSLRAVTPQQIATVLA 221 Query: 230 AKTRDLHIQSHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELN 289 A DL + HI+E + EV+ + S + +N + + + H + E+ Sbjct: 222 AGHDDLPVHIHIAEQQKEVDDCQA--WSGRRPLQWLYENVAVDQRWCLVHATHADPAEVA 279 Query: 290 VFHERGASIAHCPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMV 349 GA C ++ +L G + L ++G+G+D S S+++ +R Sbjct: 280 AMARSGAVAGLCLSTEANLGDGIFPATDFLAQGGRLGIGSD--SHVSLSVVEELRWLEYG 337 Query: 350 SNILLINKV----NEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKAS 405 + + +++ + + ++ A GG+QALG IG+ VG+ D ++++ + Sbjct: 338 QRLRDRKRNRLYRDDQPMIGRTLYDAALAGGAQALGQP--IGSLAVGRRADLLVLD--GN 393 Query: 406 DSPIDLFYGDFFGDISEAVIQKFLYLGDDRNIEEVYVGGKQVV 448 D + GD A++ ++L+ G DR + +V V G+ VV Sbjct: 394 DPYLASAEGD-------ALLNRWLFAGGDRQVRDVMVAGRWVV 429 >2BB0-A nrPDB Length = 421 Score = 83.7 bits (205), Expect = 2e-16, Method: Composition-based stats. Identities = 65/392 (16%), Positives = 128/392 (32%), Gaps = 57/392 (14%) Query: 26 MEVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHA 85 + V+ D ++G+ + KIVF + + + PGLVD H H Sbjct: 32 LHVIEDAVVGIHEQ-KIVFAGQKGAEAGYE-------ADEIIDCSGRLVTPGLVDPHTH- 82 Query: 86 SQYSFAGSSIDLPLLEWLTKYTF-----PAEHRFQNIDFAEEVYTRVVR--------RTL 132 G S + + L ++ + + R L Sbjct: 83 ---LVFGGSREKEMNLKLQGISYLDILAQGGGILSTVKDTRAASEEELLQKAHFHLQRML 139 Query: 133 KNGTTTACYF--ATIHTDSSLLLADITDKF--GQRAFVGKVCMDLNDTFPEYKETTEESI 188 GTTTA + ++ L + K Q + M + PEY+ ++ + Sbjct: 140 SYGTTTAEVKSGYGLEKETELKQLRVAKKLHESQPVDLVSTFMGAHAIPPEYQNDPDDFL 199 Query: 189 KETERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEV 248 + + E+ ++ + I T + S++ A ++ H DE+ Sbjct: 200 DQMLSLLPEIKEQELASFADIFTETGVFTVSQS--RRYLQKAAEAGFGLKIH----ADEI 253 Query: 249 EAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAHCPNSNLSL 308 + + + K H S E + E G P + L Sbjct: 254 DPLGGAELAGKLKA------------VSADHLVGTSDEGIKKLAEAGTIAVLLPGTTFYL 301 Query: 309 S-SGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKE 367 S + ++ V + L TD G S + I+ + ++ + L +T +E Sbjct: 302 GKSTYARARAMIDEGVCVSLATDFNPGSS--PTENIQLIMSIAALHLK-------MTAEE 352 Query: 368 VFRLATLGGSQALGLDGEIGNFEVGKEFDAIL 399 ++ T+ + A+G E G + G+ D ++ Sbjct: 353 IWHAVTVNAAYAIGKGEEAGQLKAGRSADLVI 384 >2P9B-A nrPDB Length = 458 Score = 79.5 bits (194), Expect = 2e-15, Method: Composition-based stats. Identities = 71/430 (16%), Positives = 125/430 (29%), Gaps = 60/430 (13%) Query: 27 EVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSH-HEFFMPGLVDTHIHA 85 +LR+ + V G+I + + + P E L + MPGL++ H H Sbjct: 29 TILRNMTIVVGADGRIEQVAPSIETS--------IPAEYHYLDGTGKIVMPGLINAHTHL 80 Query: 86 SQYSFAGSSIDLPLLEWL-----TKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTAC 140 S PL L + H + L++G TT Sbjct: 81 F-------SQGKPLNPKLATPKGQRMVATFAHSPLGKPYMAATVKHNATTLLESGVTTIR 133 Query: 141 YFATIHTDSSLLLA--DITDKFGQRAFVGKVCMDL----NDTFPEYKETTEESIKETERF 194 + + L D G R M + T E + Sbjct: 134 TLGDVGYEVVTLRDQIDAGQILGPRILASGPLMAIPEGHGAPLIALTSGTPEEARTA--- 190 Query: 195 VSEMLQKNYSRVKPI----------VTPRFSLSCSETLMGELGNIAKTRDLHIQSHISEN 244 V++ L+ + +K + S S M + + A + + +H +++ Sbjct: 191 VAQNLKAGVNAIKIAATGGVTDAQEIGEAGSPQMSVEQMRAICDEAHQYGVIVGAH-AQS 249 Query: 245 RDEVEAVKNLYPSYKNYTSVYDK--NNLLTNKTVMAHG------CYLSAEELNVFHE--R 294 + V + SV D + + G + L + + Sbjct: 250 PEGVRRSLLAGVDTIEHGSVLDDELIGMFRHNPNALRGYSALIPTLSAGLPLTLLGQDVT 309 Query: 295 GASIAHCPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILL 354 G + NS + + + + IG+GTD + L Sbjct: 310 GITDIQLENSKNVVGGMVSGARQAHEAGLMIGVGTDTG---------MTFVPQYATWREL 360 Query: 355 INKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDSPIDLFYG 414 V + E AT + LG+D E G+ EVGK D +++N D L + Sbjct: 361 ELLVAYAGFSPAEALHAATAVNASILGVDAETGSLEVGKSADLLVLNANPLDDLRALEHP 420 Query: 415 DFFGDISEAV 424 V Sbjct: 421 ALVIAAGHPV 430 >3MKV-A nrPDB Length = 426 Score = 79.5 bits (194), Expect = 3e-15, Method: Composition-based stats. Identities = 58/378 (15%), Positives = 108/378 (28%), Gaps = 44/378 (11%) Query: 53 KLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEH 112 +++ + + MPGL+D H+H F +LP + L Sbjct: 36 EVSDKPIKSSNAHVIDVKGKTIMPGLIDLHVHVVAIEF-----NLPRVATLPNVLVTLRA 90 Query: 113 RFQNIDFAEEVYTRVVRRT-----LKNGTTTACYFATIHTDSSLLLADITDKFGQRAFVG 167 +T V K + S L+ RA Sbjct: 91 VPIMRAMLRRGFTTVRDAGGAGYPFKQAVESGLVEGPRLFVSGRALSQTGGHADPRARSD 150 Query: 168 -------KVCMDLNDTFPEYKETTEESIKETERFVSEMLQKNYSRVKPIVT----PRFSL 216 C + +E + + + V P Sbjct: 151 YMPPDSPCGCCVRVGALGRVADGVDEVRRAVREELQMGADQIKIMASGGVASPTDPVGVF 210 Query: 217 SCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTV 276 SE + + A+ R ++ +H AV+ + + T + V Sbjct: 211 GYSEDEIRAIVAEAQGRGTYVLAHAYTPAAIARAVR----CGVRTIEHGNLIDDETARLV 266 Query: 277 MAHGCYLSAEEL--NVFHERGASIAHCPNSNLSL----SSGFLNVLEVLKHEVKIGLGTD 330 HG Y+ + + G P S + +G ++ + + VK+G GTD Sbjct: 267 AEHGAYVVPTLVTYDALASEGEKYGLPPESIAKIADVHGAGLHSIEIMKRAGVKMGFGTD 326 Query: 331 VAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFE 390 + G D R + L+ EV AT+ ++ LG+ ++G Sbjct: 327 LLGEAQRLQSDEFRILA-------------EVLSPAEVIASATIVSAEVLGMQDKLGRIV 373 Query: 391 VGKEFDAILINPKASDSP 408 G D ++++ S Sbjct: 374 PGAHADVLVVDGNPLKSV 391 >4CQD-A nrPDB Length = 423 Score = 77.6 bits (189), Expect = 1e-14, Method: Composition-based stats. Identities = 66/414 (15%), Positives = 139/414 (33%), Gaps = 38/414 (9%) Query: 28 VLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQ 87 ++R+ L DS + + + K+ + + + + PG VD H H + Sbjct: 28 IIRNAYLSEKDSVYDIGIV-GDRIIKIEAKIEGTVKDEID-AKGNLVSPGFVDAHTHMDK 85 Query: 88 YSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTACYFATIHT 147 F + LP W YT + + + ++R + T++T Sbjct: 86 S-FTSTGERLPKF-WSRPYT-RDAAIEDGLKYYKNATHEEIKRHVIEHAHMQVLHGTLYT 142 Query: 148 DSSLLLADITDKFGQRAFV-GKVCMDLNDTFPEYKETTEESIKETERFVSEMLQKNYS-R 205 + + + + A + K + + E + Sbjct: 143 RTHVDVDSVAKTKAVEAVLEAKEELKDLIDIQVVAFAQSGFFVDLESESLIRKSLDMGCD 202 Query: 206 VKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKNLYPSYKNYTSVY 265 + V P + E + +AK D+ I HI + +Y S Sbjct: 203 LVGGVDPATRENNVEGSLDLCFKLAKEYDVDIDYHIHDI-----GTVGVY-SINRLAQKT 256 Query: 266 DKNNLLTNKTVMAHGCYLS------AEELNVFHERGASIAHCPNSNLSLSSGFLNVLEVL 319 +N T A C+ E + ++ + G C +S + V+++L Sbjct: 257 IENGYKGRVTTSAAWCFADAPSEWLDEAIPLYKDSGMKFVTCFSSTPP----TMPVIKLL 312 Query: 320 KHEVKIGLGTD------VAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLAT 373 + + +G +D V G D ++ A++ + L + + L ++++ T Sbjct: 313 EAGINLGCASDNIRDFWVPFGNG----DMVQGALIETQRLELKTNRDLGL----IWKMIT 364 Query: 374 LGGSQALGLDGEIGNFEVGKEFDAILINPKASDSPIDLFYGDFFGDISEAVIQK 427 G++ LG++ G EVGK+ D +++N + I + +I K Sbjct: 365 SEGARVLGIEKNYG-IEVGKKADLVVLNSLSPQWAIIDQAKRLCVIKNGRIIVK 417 >2PUZ-A nrPDB Length = 419 Score = 77.2 bits (188), Expect = 1e-14, Method: Composition-based stats. Identities = 65/398 (16%), Positives = 118/398 (29%), Gaps = 64/398 (16%) Query: 29 LRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQY 88 + + ++ V + G+I F S + + P L+D H H Sbjct: 37 VENAVIAVRN-GRIAFAGPESDLPD-----DLSTADETTDCGGRWITPALIDCHTH---- 86 Query: 89 SFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRR-------------TLKNG 135 G + + L T+ + + TR + L G Sbjct: 87 LVFGGNRAMEFEMRLNGATYEEIAKAGGGIVSSVRDTRALSDEVLVAQALPRLDTLLSEG 146 Query: 136 TTTA----CYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESIKET 191 +T Y I T+ +L + + + + + T +YK + I + Sbjct: 147 VSTIEIKSGYGLDIETELKMLRVARRLETLRPVRIVTSYLAAHATPADYKGRNADYITDV 206 Query: 192 -----ERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRD 246 E+ +E L + S E + A+ R L ++ H +E Sbjct: 207 VLPGLEKAHAEGLADAVDGFCEGIA----FSVKEI--DRVFAAAQQRGLPVKLH-AEQLS 259 Query: 247 EVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAHCPNSNL 306 + + Y N H YL + G P + Sbjct: 260 NLG--------GAELAASY-------NALSADHLEYLDETGAKALAKAGTVAVLLPGAFY 304 Query: 307 SL-SSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTL 365 +L V + +I L TD G S + + M + + +T+ Sbjct: 305 ALREKQLPPVQALRDAGAEIALATDCNPGTS-PLTSLLLTMNMGATLFR--------MTV 355 Query: 366 KEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPK 403 +E T ++ALGL E G E GK D + + + Sbjct: 356 EECLTATTRNAAKALGLLAETGTLEAGKSADFAIWDIE 393 >2OOF-A nrPDB Length = 416 Score = 76.0 bits (185), Expect = 3e-14, Method: Composition-based stats. Identities = 63/389 (16%), Positives = 127/389 (32%), Gaps = 50/389 (12%) Query: 28 VLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQ 87 +L H LGV + G+I L + P +++ + PGL+D H H Sbjct: 26 LLEPHALGVHE-GRIHALVPMQDLKG------PYPAHWQDMKG-KLVTPGLIDCHTHLIF 77 Query: 88 YSFAGSSIDLPLLEWLTKYTFPAEH---------RFQNIDFAEEVYTRVVRRTLKNGTTT 138 +L R + D E+ V+ ++ G TT Sbjct: 78 AGSRAEEFELRQKGVPYAEIARKGGGIISTVRATRAASEDQLFELALPRVKSLIREGVTT 137 Query: 139 ACYF--ATIHTDSSLLLADITDKFG--QRAFVGKVCMDLNDTFPEYKETTEESIKET-ER 193 + + L + + + G V + + PEY++ + ++ + Sbjct: 138 VEIKSGYGLTLEDELKMLRVARRLGEALPIRVKTTLLAAHAVPPEYRDDPDSWVETICQE 197 Query: 194 FVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKN 253 + + + + S ++T ++ A L ++ H+ Sbjct: 198 IIPAAAEAGLADAVDVFCEHIGFSLAQT--EQVYLAADQYGLAVKGHM----------DQ 245 Query: 254 LYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAHCPNSNLSL-SSGF 312 L + + L+ H YL E + RG P + L + Sbjct: 246 LSNLGGSTLA--ANFGALSVD----HLEYLDPEGIQALAHRGVVATLLPTAFYFLKETKL 299 Query: 313 LNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLA 372 V+ + K V + + +D+ + + ++R A+ ++ L LT E Sbjct: 300 PPVVALRKAGVPMAVSSDI--NPGTAPIVSLRMAMNMACTLF-------GLTPVEAMAGV 350 Query: 373 TLGGSQALGLDGEIGNFEVGKEFDAILIN 401 T ++ALG ++G VG D ++ N Sbjct: 351 TRHAARALGEQEQLGQLRVGMLADFLVWN 379 >4WGX-A nrPDB Length = 465 Score = 63.7 bits (153), Expect = 1e-10, Method: Composition-based stats. Identities = 68/462 (14%), Positives = 145/462 (31%), Gaps = 100/462 (21%) Query: 12 IFRGTFVHSTWTCPMEVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHH 71 I GT + P+ + + + D G+I + Q E P + + Sbjct: 7 IVGGTLIDGNGGVPVP---ETTVFIED-GRITKVGSTDQIE-------VHPNIRQIDAQG 55 Query: 72 EFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRT 131 ++ +PGLV+ ++H + L RF+ + +V + Sbjct: 56 KWILPGLVNGNVHLLDGIMMMGRGGIEYL-----------ARFEGNYY--KVIEEAAQIA 102 Query: 132 LKNGTTTACYFATIHTDSSLLLADITD--KFGQRAFVGKVCMDLNDTF------PEYKET 183 L+ G TT ++ I G R F + + F P + Sbjct: 103 LRGGVTTVFDTWNALEPVTIARDRIASGAAEGARIFFAGTLIGMGGPFTGDFMRPSMQAR 162 Query: 184 TEESIKETER-----------------------FVSEMLQKNYSRVKPIVTPRFS----- 215 T S +R + E L++ K VT Sbjct: 163 TVMSRTFADRMDAMFEVGMGRHLSTLPPAEVRPLIREYLERGVDFCKIAVTDHLVGLLGF 222 Query: 216 ----LSCSETLMGELGNIAKTRDLHIQSHISE-----NRDEVEAVKNLYPS--YKNYTSV 264 + SE ++ L + + + + +H + E +A ++ + + Sbjct: 223 RAPYFTFSERVLDVLVDEVRRAGVPLLTHTTSLEGLNTAIERDADLMIHATMTGQAPIPE 282 Query: 265 YDKNNLLTNKTV-------MAHGCYLSAEELNVFHERGASIAHCPNSNLSLSSGFLNVLE 317 LL + +A ++ + + + F + + H N + Sbjct: 283 ETIEKLLEKQLWSEVQPTTIAQQAWMDSVD-HPFADFSGRVHH------------ENDVR 329 Query: 318 VLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNI--------LLINKVNEKSLTLKEVF 369 ++K V + LGTD AG +L+ + + + + + + EK + Sbjct: 330 MIKAGVPLVLGTD-AGCTDPDILEDMSQGELHERPWTLGEDHFVWMQAMVEKGMDPMAAI 388 Query: 370 RLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDSPIDL 411 T ++A E+G+ +VGK D ++++ ++ Sbjct: 389 LAGTANPAKAYRKFDELGSIDVGKLGDVVVLDQDPLADITNM 430 >1R9X-A nrPDB Length = 430 Score = 62.9 bits (151), Expect = 3e-10, Method: Composition-based stats. Identities = 53/395 (13%), Positives = 114/395 (28%), Gaps = 55/395 (13%) Query: 34 LGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQYSFAGS 93 + + D GKI ++ S E + +P V+ HIH AG Sbjct: 26 IHLQD-GKISAIDAQSGVM--------PITENSLDAEQGLVIPPFVEPHIHLDTTQTAGQ 76 Query: 94 ---SIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTACYFATIHTDSS 150 + L E + + D ++ + ++ + NG + + Sbjct: 77 PNWNQSGTLFEGIE--RWAERKALLTHDDVKQRAWQTLKWQIANGIQHVRTHVDVSDATL 134 Query: 151 LLLADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESIKETERFVSEMLQKNYSRVKPIV 210 L + + +DL + + S E + E L+ Sbjct: 135 TALKAMLEVK----QEVAPWIDLQIV--AFPQEGILSYPNGEALLEEALR--LGADVVGA 186 Query: 211 TPRFSLSCSE--TLMGELGNIAKTRDLHIQSHISENRDEVEAVKNLYPSYKNYTSVYDKN 268 P F + + + +A+ D I H E DE + + + Sbjct: 187 IPHFEFTREYGVESLHKTFALAQKYDRLIDVHCDEIDDEQSR-------FVETVAALAHH 239 Query: 269 NLLTNKTVMAHGCYL-------SAEELNVFHERGASIAHCPNSNLSLSS---------GF 312 + + +H + ++ + G + P N+ L G Sbjct: 240 EGMGARVTASHTTAMHSYNGAYTSRLFRLLKMSGINFVANPLVNIHLQGRFDTYPKRRGI 299 Query: 313 LNVLEVLKHEVKIGLGTDVAGG--YSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFR 370 V E+L+ + + G D Y + ++ M ++ + + + + Sbjct: 300 TRVKEMLESGINVCFGHDGVFDPWYPLGTANMLQVLHMGLHVCQLMGYGQ----INDGLN 355 Query: 371 LATLGGSQALGLDGEIGNFEVGKEFDAILINPKAS 405 L T ++ L L G + I++ + Sbjct: 356 LITHHSARTLNLQDY--GIAAGNSANLIILPAENG 388 >3N2C-A nrPDB Length = 423 Score = 61.0 bits (146), Expect = 1e-09, Method: Composition-based stats. Identities = 65/416 (15%), Positives = 131/416 (31%), Gaps = 47/416 (11%) Query: 28 VLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQ 87 VL +H V D +IV ++ P + MPG +D H+H Sbjct: 20 VLLEHHHVVIDGERIV---------EVTDRPVDLPNAQAIDVRGKTVMPGFIDCHVHVLA 70 Query: 88 Y-SFAGSSIDLP-------LLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTA 139 + G + P L L ++ A+ + V L +G Sbjct: 71 SNANLGVNATQPNILAAIRSLPILDAMLSRGFTSVRDAGGADWSLMQAVETGLVSGPR-- 128 Query: 140 CYFATIHTDSSLLLADITDKFGQRAFVGKVCMD-LNDTFPEYKETTEESIKE-TERFVSE 197 + + + D + + E +++E ++ ++ Sbjct: 129 IFPSGKALSQTGGHGDFRPRGDLLEPCSCCFRTGAIARVVDGVEGVRLAVREEIQKGATQ 188 Query: 198 MLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKNLYPS 257 + V P + SE + + + A+ + ++ +H R AV+ Sbjct: 189 IKIMASGGVASPTDPIANTQYSEDEIRAIVDEAEAANTYVMAHAYTGRAIARAVR----C 244 Query: 258 YKNYTSVYDKNNLLTNKTVMAHG--CYLSAEELNVFHERGASIAHCPNSNLSLSS----G 311 + + K + HG + + + GA P S ++S G Sbjct: 245 GVRTIEHGNLVDEAAAKLMHEHGAFVVPTLVTYDALAKHGAEFGMPPESVAKVASVQQKG 304 Query: 312 FLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRL 371 ++ VK+G G+D+ G R + + L E R Sbjct: 305 RESLEIYANAGVKMGFGSDLLGEMHAFQSGEFR-------------IRAEVLGNLEALRS 351 Query: 372 ATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDSPIDLFYGDFFGDISEAVIQK 427 AT ++ + + G++G VG D ++++ + D+ G E V+Q+ Sbjct: 352 ATTVAAEIVNMQGQLGVIAVGAIADLVVLD---GNPLEDIGVVADEGARVEYVLQR 404 >3MTW-A nrPDB Length = 403 Score = 59.9 bits (143), Expect = 2e-09, Method: Composition-based stats. Identities = 67/423 (15%), Positives = 123/423 (29%), Gaps = 101/423 (23%) Query: 31 DHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQYSF 90 D+ L + G+I + + +L +PGL+D H+H + Sbjct: 21 DNPLVIVTDGRITSIGKKGDA-------VPAGATAVDLPG-VTLLPGLIDMHVHLDSLAE 72 Query: 91 AGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTACYFATIHTDSS 150 G L RF ++ V T ++TL+ G TT D Sbjct: 73 VGGYNSLEY-----------SDRFWSV-----VQTANAKKTLEAGFTTVRNVGAADYDDV 116 Query: 151 LLLADITDKF--GQRAFVGK----------------VCMDLNDTF-PEYKETTEESIKET 191 L I + G R MD + F + + ++++ Sbjct: 117 GLREAIDAGYVPGPRIVTAAISFGATGGHCDSTFFPPSMDQKNPFNSDSPDEARKAVRTL 176 Query: 192 ERFVSEMLQ--KNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVE 249 +++ +++++ P + M + + A + + +H E Sbjct: 177 KKYGAQVIKICATGGVFSRGNEP-GQQQLTYEEMKAVVDEAHMAGIKVAAHAHGASGIRE 235 Query: 250 AVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAHCP------- 302 AV+ + H + E + + ++GA + Sbjct: 236 AVRA----GVDTIE---------------HASLVDDEGIKLAVQKGAYFSMDIYNTDYTQ 276 Query: 303 ---NSNLSLSSGF-----------LNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVM 348 N L N + LK VK+ GTD V Sbjct: 277 AEGKKNGVLEDNLRKDRDIGELQRENFRKALKAGVKMVYGTDAGIYPHGDNAKQFAVMVR 336 Query: 349 VSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDSP 408 T + + ATL ++ALG ++G VG+ D I + A D Sbjct: 337 Y------------GATPLQAIQSATLTAAEALGRSKDVGQVAVGRYGDMIAV---AGDPL 381 Query: 409 IDL 411 D+ Sbjct: 382 ADV 384 >4WHB-E nrPDB Length = 461 Score = 59.5 bits (142), Expect = 3e-09, Method: Composition-based stats. Identities = 63/429 (14%), Positives = 126/429 (29%), Gaps = 63/429 (14%) Query: 30 RDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHA--SQ 87 R + + + + + + + +PG V+ ++H + Sbjct: 20 RPATTVIVEGDRFATVGPSDSTP-------VPEGATVVDGNRRWMVPGYVNGNVHLLDAW 72 Query: 88 YSFAGSSIDLPLLEWLTKYT--FPAEHRFQNIDFAEEVYT--------RVVRRTLKNGTT 137 AG L W +Y + + V+ R + G + Sbjct: 73 MFMAGPGTIEYLARWEGRYVEVIEEAAQLALRNGVTTVFDTHNAIEPVLAARDRINAGIS 132 Query: 138 TAC-YFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESI---KETER 193 FA F R + +D D+ E + S+ KE Sbjct: 133 QGARIFAAGTIVGMGGPFSADFHFAGRTAATRTFVDRIDSMFEAGVGHQLSLLPRKEVRA 192 Query: 194 FVSEMLQKNYSRVKPIVTPRFSLSC--------------SETLMGELGNIAKTRDLHIQS 239 V + L + +K V+ + S ++ + A+ + + + Sbjct: 193 RVRDYLSRGVDMLKIAVSDHIVFTLVDRSVGFDRSYQTFSRPVLEVMVEEARAAGVPVLT 252 Query: 240 H-----ISENRDEVEA---VKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCY-LSAEELNV 290 H + E+ A + Y + + + ++ + + L Sbjct: 253 HSVSVEALDTSVELGADVLIHANYTLGQEIPNYLIDKIVASDSWAGLQTVHDQHRQGLED 312 Query: 291 FHERGASIAHCPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVS 350 A++A P + N ++ KI L TD AG S L + Sbjct: 313 VGSWAAALAGEPYAT--------NERNLISANAKILLNTD-AGCPSKDHLADLSPVERED 363 Query: 351 NI--------LLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINP 402 + EK ++ E AT+ ++A G +IG+ E GK D +L++ Sbjct: 364 RPWTIGNDHFHWTQSMVEKGMSPLEAISAATINVARAYGKADQIGSVETGKLADFVLLDQ 423 Query: 403 KASDSPIDL 411 D +L Sbjct: 424 DPVDDIRNL 432 >4C65-A nrPDB Length = 438 Score = 56.8 bits (135), Expect = 2e-08, Method: Composition-based stats. Identities = 76/467 (16%), Positives = 139/467 (29%), Gaps = 88/467 (18%) Query: 14 RGTFVHSTWTCPM--EVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHH 71 + T +++ P E LR+ L +SD I F+ + K + Sbjct: 6 KVTIIYAGLLIPGDGEPLRNAALVISDK-IIAFVGSEADIPKKYLRSTQSTHRV------ 58 Query: 72 EFFMPGLVDTHIHASQYSFAGSSIDL--PLLEWLTKYTFPAEHRFQN--IDFAEEVYTRV 127 MPGL D H+H G D L + + R + + YT Sbjct: 59 PVLMPGLWDCHMHF------GGDDDYYNDYTSGLATHPASSGARLARGCWEALQNGYT-S 111 Query: 128 VRRTLKNGT-------TTACYFATIHTDSSLL--LADITDKFGQRAFVGKVCMDLNDTFP 178 R G +++ + L A D F A + + P Sbjct: 112 YRDLAGYGCEVAKAINDGTIVGPNVYSSGAALSQTAGHGDIFALPAGEVLGSYGVMNPRP 171 Query: 179 EYKETTEESIKETERFVSEMLQKNYSRVKPIVTPRFSLSC------------SETLMGEL 226 Y I + V ++ R ++ S S + + Sbjct: 172 GYWGAGPLCIADGVEEVRRAVRLQIRRGAKVIKVMASGGVMSRDDNPNFAQFSPEELKVI 231 Query: 227 GNIAKTRDLHIQSHISENRDEVEAVK-------NLYPSYKNYTSVYDKNNLLTNKTVMAH 279 A ++ + +H+ + A+K ++ + + + + +L T Sbjct: 232 VEEAARQNRIVSAHVHGKAGIMAAIKAGCKSLEHVSYADEEVWELMKEKGILYVATRSVI 291 Query: 280 GCYLSAEELNVFHERGASIAHCPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSM 339 +L++ + E A + +S+L G +K V I LGTD A G Sbjct: 292 EIFLASNGEGLVKESWAKLQALADSHLKAYQG------AIKAGVTIALGTDTAPGGP--- 342 Query: 340 LDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEI-GNFEVGKEFDAI 398 + + L V +T E + AT ++G + G G E D I Sbjct: 343 ----------TALELQFAVERGGMTPLEAIKAATANAPLSVGPQAPLTGQLREGYEADVI 392 Query: 399 LINPKASDSPIDLFYGDFFGDISEAVIQKFLYLGDDRNIEEVYVGGK 445 + E ++ + + + V+ GGK Sbjct: 393 ALE--------------------ENPLEDIKVFQEPKAVTHVWKGGK 419 >2QS8-A nrPDB Length = 418 Score = 54.1 bits (128), Expect = 1e-07, Method: Composition-based stats. Identities = 56/385 (14%), Positives = 110/385 (28%), Gaps = 68/385 (17%) Query: 64 EIRELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEV 123 + +L H PGL+D H+H Q + + +E + +H + Sbjct: 52 DYIDLRDHTVL-PGLMDMHVHFGQ-EYQSKAQAPIKVEREMQAILATQHAYVTFKSGFTT 109 Query: 124 YTRVVRRTLKNGTTTACYFATIHTDSSLLLA--DITDKFGQR-AFVGKVCMDLNDTFPEY 180 +V L + + + A I G GK D + PE Sbjct: 110 VRQVGDSGLVAISLRDAINSGKLAGPRIFAAGKTIATTGGHADPTNGKAVDDYDYPVPEQ 169 Query: 181 KETTEESIKETERFVSEMLQKNYSRVKPIVTPRF--------SLSCSETLMGELGNIAKT 232 E V + + +K VT + ++ + + + AK Sbjct: 170 GVVNGPY--EVYAAVRQRYKDGADGIKITVTGGVLSVAKSGQNPQFTQEEVDAVVSAAKD 227 Query: 233 RDLHIQSHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFH 292 + + H E +K + + HG ++ E +++ Sbjct: 228 YGMWVAVHAH----GAEGMKRAIKAGVDSIE---------------HGTFMDLEAMDLMI 268 Query: 293 ERGASIAHCPNSNLSLS-----SGFLN-----------------VLEVLKHEVKIGLGTD 330 E G ++ ++ F + + VKI GTD Sbjct: 269 ENGTYYVPTISAGEFVAEKSKIDNFFPEIVRPKAASVGPQISDTFRKAYEKGVKIAFGTD 328 Query: 331 VAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFE 390 + V E + + + AT+ ++ L ++ ++G+ E Sbjct: 329 AGVQKHGTNWKEFVYMV------------ENGMPAMKAIQSATMETAKLLRIEDKLGSIE 376 Query: 391 VGKEFDAILINPKASDSPIDLFYGD 415 GK D I + + L D Sbjct: 377 SGKLADLIAVKGNPIEDISVLENVD 401 >2OGJ-A nrPDB Length = 417 Score = 49.1 bits (115), Expect = 4e-06, Method: Composition-based stats. Identities = 65/403 (16%), Positives = 124/403 (30%), Gaps = 90/403 (22%) Query: 34 LGVSDSGKIVFLEEASQQEKLAKEWCFKPCEI-RELSHHEFFMPGLVDTHIHASQYSFAG 92 + + GKI + A Q P + R + F PG VD H+H Sbjct: 38 ILIGGDGKIAAVGSALQA----------PADTQRIDAKGAFISPGWVDLHVH-------- 79 Query: 93 SSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTACYFATIHTDSSLL 152 +I +E R V + G+ F + Sbjct: 80 ---------------IWHGGTDISIRPSECGAERGVTTLVDAGSAGEANFHGF---REYI 121 Query: 153 LADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESIKETERFVSEMLQKNYSRVKPIVTP 212 + ++ +G + + + PE ++ + + +R + + + V V Sbjct: 122 IEPSRERIKAFLNLGSIGLVACNRVPELRDIKD---IDLDRILECYAENSEHIVGLKVRA 178 Query: 213 RFSLSCS--ETLMGELGNIAKTRDLHIQSHISENRDEVEAVKNLYPSYKNYTSVYDK-NN 269 ++ S T + IAK + + H+ E ++YD+ Sbjct: 179 SHVITGSWGVTPVKLGKKIAKILKVPMMVHVGE-----------------PPALYDEVLE 221 Query: 270 LLTNKTVMAHGCY-------LSAEELNVFHERGASIAHCPNSNLSL------SSGFLNVL 316 +L V+ H + E+L ER C + L +S V Sbjct: 222 ILGPGDVVTHCFNGKSGSSIMEDEDLFNLAER------CAGEGIRLDIGHGGASFSFKVA 275 Query: 317 EVLKHE--VKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATL 374 E + + TD+ G+S + A +S +L ++ + + V T Sbjct: 276 EAAIARGLLPFSISTDLH-GHSMN-FPVWDLATTMSKLLSVD------MPFENVVEAVTR 327 Query: 375 GGSQALGLDGEIGNFEVGKEFDAILINPKASDSPIDLFYGDFF 417 + + LD E +VG+ D + + +D GD Sbjct: 328 NPASVIRLDME-NRLDVGQRADFTVFDLVDADLEATDSNGDVS 369 >3OOQ-A nrPDB Length = 396 Score = 49.1 bits (115), Expect = 5e-06, Method: Composition-based stats. Identities = 59/370 (15%), Positives = 118/370 (31%), Gaps = 46/370 (12%) Query: 44 FLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWL 103 L + EK+ + EI +L+ +F PG VD H H + G Sbjct: 26 VLVSNGKVEKVGENIEDPDAEIVDLTG-KFLFPGFVDAHSHIGLFE-EGVGYYYSDGNEA 83 Query: 104 TKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTACYFATIHTDSSLLLADITDKFGQR 163 T P + + R L G T+ I S+ + R Sbjct: 84 TDPVTPHVKALDGFNPQDPAIERA----LAGGVTSVM----IVPGSANPVGGQGSVIKFR 135 Query: 164 AFVGKVCMDLNDTFPEYKETTEESIKETERFVSEMLQKNYSRVKPIVTPRFSLSCSETLM 223 + + + C+ P + + +R E Q +R+ R + + M Sbjct: 136 SIIVEECI---VKDPAGLKMA--FGENPKRVYGERKQTPSTRMGTAGVIRDYFTKVKNYM 190 Query: 224 GELGNIAKTRD-----LHIQSHISENRDEVEAVKNLYPSYKN----YTSVYDKNNLLTNK 274 + +A+ ++ + E + ++ + + ++ Sbjct: 191 KK-KELAQKEGKEFTETDLKMEVGEMVLRKKIPARMHAHRADDILTAIRIAEEFGF---N 246 Query: 275 TVMAHGCYLSAEELNVFHERGASIAHCP----NSNLSLSSGFLN-VLEVLKHEVKIGLGT 329 V+ HG V E+ + P + L L + + ++LK V I L Sbjct: 247 LVIEHGTEAYKIS-KVLAEKKIPVVVGPLLTFRTKLELKDLTMETIAKLLKDGVLIALMC 305 Query: 330 DVAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNF 389 D ++ V + + E + ++ T+ ++ LGL+ IG+ Sbjct: 306 DHP------VIPLEFATVQAATAMRYGAKEED------LLKILTVNPAKILGLEDRIGSI 353 Query: 390 EVGKEFDAIL 399 E GK+ D ++ Sbjct: 354 EPGKDADLVV 363 >1XRT-A nrPDB Length = 467 Score = 48.3 bits (113), Expect = 7e-06, Method: Composition-based stats. Identities = 62/423 (14%), Positives = 123/423 (29%), Gaps = 95/423 (22%) Query: 23 TCPMEVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTH 82 P + L + ++GKI + + P + PG +D H Sbjct: 57 IDPSQNLEGEFDILVENGKIKKI----------DKNILVPEAEIIDAKGLIVCPGFIDIH 106 Query: 83 IHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTACYF 142 +H P + ++I+ + G TT Sbjct: 107 VHL---------------------RDPGQTYKEDIESGSRCA-------VAGGFTTIVCM 138 Query: 143 ATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESIKETERFVSEMLQKN 202 + ++ + T ++ + K Sbjct: 139 PNTNPPIDNTTVVNYILQKSKSVGLCRVL---------PTGTITKGRKGKEIADFYSLKE 189 Query: 203 YSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISE--------NRDEVEAVKNL 254 V T S ++M + +A + I H + N EV A+ L Sbjct: 190 AGCV--AFTDDGSPVMDSSVMRKALELASQLGVPIMDHCEDDKLAYGVINEGEVSALLGL 247 Query: 255 YPSYKNYTSV-YDKNNLLTNKTV-MAHGCYLSA----EELNVFHERGASIAHCPNSNLSL 308 + ++ +L +T H ++S E + F E+G I N N L Sbjct: 248 SSRAPEAEEIQIARDGILAQRTGGHVHIQHVSTKLSLEIIEFFKEKGVKITCEVNPNHLL 307 Query: 309 -------SSGF-----LNVLEVLKH-----EVKIGL----GTDVAGGYSYSMLDAIRRAV 347 +SG + + VK G+ TD A ++ + Sbjct: 308 FTEREVLNSGANARVNPPLRKKEDRLALIEGVKRGIIDCFATDHAPHQTFE--KELVEFA 365 Query: 348 MVSNILLINKVN-------EKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILI 400 M I L + + ++LK++ + T+ ++ +G+D +G ++G D + Sbjct: 366 MPGIIGLQTALPSALELYRKGIISLKKLIEMFTINPARIIGVD--LGTLKLGSPADITIF 423 Query: 401 NPK 403 +P Sbjct: 424 DPN 426 >1YRR-A nrPDB Length = 382 Score = 44.1 bits (102), Expect = 1e-04, Method: Composition-based stats. Identities = 62/401 (15%), Positives = 120/401 (29%), Gaps = 72/401 (17%) Query: 27 EVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHAS 86 E L DH + ++D G I + ++ E R L+ PG +D Sbjct: 14 EFLDDHAVVIAD-GLIKSVCPVAEL--------PPEIEQRSLNG-AILSPGFIDVQ---- 59 Query: 87 QYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTACYFATIH 146 G +F + A V T + + + Y T+ Sbjct: 60 ---LNGCGG----------------VQFNDTAEAVSVETLEIMQKANEKSGCTNYLPTL- 99 Query: 147 TDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEYKETT-----------EESIKETERFV 195 + +D K G R + N + E +++ + + Sbjct: 100 ----ITTSDELMKQGVRVMREYLAKHPNQALGLHLEGPWLNLVKKGTHNPNFVRKPDAAL 155 Query: 196 SEMLQKNYSRV-KPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKNL 254 + L +N + K + P + + + G + + ++ Sbjct: 156 VDFLCENADVITKVTLAPEMVPAEVISKLANAGIVVSAGHSNATLKEAKAGFRAGITFAT 215 Query: 255 YPSYKNYTSVYDKNNLLTNKT--------VMAHGCYLSAEELNVFHERGASIAHCPNSNL 306 + + L ++A G ++ + +R C ++ Sbjct: 216 HLYNAMPYITGREPGLAGAILDEADIYCGIIADGLHVDYANIRN-AKRLKGDKLCLVTDA 274 Query: 307 SLSSGFLNVLEVLKHEVKI----GLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNEKS 362 + +G N+ + + I GL D G S S L I N V Sbjct: 275 TAPAG-ANIEQFIFAGKTIYYRNGLCVDENGTLSGSSLTMIEGVR--------NLVEHCG 325 Query: 363 LTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPK 403 + L EV R+ATL ++A+G++ +G GK + P Sbjct: 326 IALDEVLRMATLYPARAIGVEKRLGTLAAGKVANLTAFTPD 366 >1NFG-A nrPDB Length = 457 Score = 44.1 bits (102), Expect = 1e-04, Method: Composition-based stats. Identities = 67/423 (15%), Positives = 130/423 (30%), Gaps = 64/423 (15%) Query: 17 FVHSTWTCPMEVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMP 76 + + + + LG+ D GKI + A P E + + P Sbjct: 4 IIKNGTIVTADGISRADLGIKD-GKITQIGGA-----------LGPAERTIDAAGRYVFP 51 Query: 77 GLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVR----RTL 132 G +D H H SF S D + + + ++ + Sbjct: 52 GGIDVHTHVETVSFNTQSADTFATATVAAACG-GTTTIVDFCQQDRGHSLAEAVAKWDGM 110 Query: 133 KNGTTTACYFATI----HTDSSLLLADITDKFGQ---RAFVGKVCMDLNDTFPEYKETTE 185 G + Y I TDS + ++ G + F+ M++ D +T + Sbjct: 111 AGGKSAIDYGYHIIVLDPTDSVIEELEVLPDLGITSFKVFMAYRGMNMIDDV-TLLKTLD 169 Query: 186 ESIKETERFVSEMLQKN---YSRVKPIVTPRF---------SLSCSETLMGELGNIAKTR 233 +++K + + Y R K + + +A+ Sbjct: 170 KAVKTGSLVMVHAENGDAADYLRDKFVAEGKTAPIYHALSRPPRVEAEATARALALAEIV 229 Query: 234 DLHIQS-HIS--ENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNV 290 + I H++ E+ +EV K+ + H YL+ E+L Sbjct: 230 NAPIYIVHVTCEESLEEVMRAKS------RGVRALAE--------TCTHYLYLTKEDLER 275 Query: 291 FHERGASIAHCPNSNLS---------LSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLD 341 GA P + L +G + H + G G + + Sbjct: 276 PDFEGAKYVFTPPARAKKDHDVLWNALRNGVFETVS-SDHCSWLFKGHKDRGRNDFRAIP 334 Query: 342 AIRRAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILIN 401 V +++ VNE ++L + L ++ G+ + G VG + D +L + Sbjct: 335 NGAPGVEERLMMVYQGVNEGRISLTQFVELVATRPAKVFGMFPQKGTIAVGSDADIVLWD 394 Query: 402 PKA 404 P+A Sbjct: 395 PEA 397 >6NBO-A nrPDB Length = 402 Score = 43.3 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 56/401 (13%), Positives = 109/401 (27%), Gaps = 49/401 (12%) Query: 45 LEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLT 104 L E + + P E +PGLV+ H H + + + W Sbjct: 28 LIEGDRIARTGPSLDAPPGCAIEEGAGAIALPGLVEGHTHLDKTHWG--------MPWYR 79 Query: 105 KYTFP---------AEHRFQNIDFAEEVYTRVVRRTLKNGTTTACYFATIHTDSSLLLAD 155 P +R + A + R L GTT + D+ L Sbjct: 80 NAVGPRLVDRIENERHYRATSGHDAGAASLALARAFLAAGTTRIRTHVDV--DTDAGLRH 137 Query: 156 ITDKFGQRAFVGKVCMDLNDTFPEYKETTEESIKETERFVSEMLQKNYSRVKPIVTPRFS 215 + R + FP+ + + + + + P Sbjct: 138 LHRVLDTRETLRGQVEIQIVAFPQSG----VLKRPGTDALLADALAAGADLLGGLDPCAI 193 Query: 216 LSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKT 275 + L IA+ + H+ E +L + +K Sbjct: 194 EGDPVKAVDVLFGIAERYGRGLDLHLHERGSMGAYSLDLI------LQRTAALG-MQHKV 246 Query: 276 VMAHGCYLS-------AEELNVFHERGASIAHCPNSNLSLSSGFLNVLEVLKHEVKIGLG 328 ++H L L E G ++ + + + S VL V + G Sbjct: 247 TISHAFCLGDLAERERDALLARMAELGVAVVTTAPAAVPVPS----VLACRAAGVTVIGG 302 Query: 329 TDVAGG--YSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEI 386 D Y D + RA++++ + + L+ T G ++ G D Sbjct: 303 NDGVRDTWTPYGSPDMLERAMLIAMRNDFRRDDA----LEVALECVTHGAARGCGFDAY- 357 Query: 387 GNFEVGKEFDAILINPKASDSPIDLFYGDFFGDISEAVIQK 427 + G D +L++ + S ++ + Sbjct: 358 -GLQPGARADVVLVDAMTLAEAVVARPVRRLVVSSGKIVAR 397 >6AJD-A nrPDB Length = 485 Score = 43.3 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 66/416 (15%), Positives = 113/416 (27%), Gaps = 52/416 (12%) Query: 60 FKPCEIRELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQN-ID 118 C++ + ++ MPG +D H H Q F G+ + + Sbjct: 38 PSGCDVLD-GGGQYLMPGGIDPHTHM-QLPFMGTVASEDFFSGTAAGLAGGTTSIIDFVI 95 Query: 119 FAEEVYTRVVRRTLKNGTTTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFP 178 T + + H + ++ + G V + ++ F Sbjct: 96 PNPRQSLLEAFHTWRGWAQKSAADYGFHVAITWWSDEVAREMG--ELVAQHGVNSFKHFM 153 Query: 179 EYKE----TTEESIKETER------------------FVSEMLQKNYSRVKPIVTPRF-S 215 YK + + ER F + P P Sbjct: 154 AYKNAIMAADDTLVASFERCLELGAVPTVHAENGELVFHLQQKLLAQGLTGPEAHPLSRP 213 Query: 216 LSCSETLMGELGNIAKTRDLHIQ-SHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNK 274 IA+T + HIS E Y V + LL + Sbjct: 214 PQVEGEAASRAIRIAETLGTPLYLVHISSREALDEIAYARAKGQPVYGEVLAGH-LLLDD 272 Query: 275 TVMAHGCYLSAEELNVFHERGASIAHCPNSNLSLSSGFLNVLEVLKH----EVKIGLGTD 330 +V H + +A V + H L SG L+ H + +G D Sbjct: 273 SVYRHPDWATAAGY-VMSPPFRPVEHQEALWRGLQSGNLHTTA-TDHCCFCAEQKAMGRD 330 Query: 331 VAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFE 390 R + L VN L++ E L + ++ L G Sbjct: 331 DFSKIPNGTAGIEDRMAL----LWDAGVNSGRLSMHEFVALTSTNTAKIFNLFPRKGAIR 386 Query: 391 VGKEFDAILINPKASDSP----------IDLFYGDFFGDISEAVIQK--FLYLGDD 434 VG + D +L +P+ S + ++F G I I + L+ D Sbjct: 387 VGADADLVLWDPQGSRTLSAATHHQRVDFNIFEGRTVRGIPSHTISQGKLLWAAGD 442 >3EWD-A nrPDB Length = 370 Score = 43.3 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 20/142 (14%), Positives = 49/142 (34%), Gaps = 18/142 (12%) Query: 213 RFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLT 272 E+ + + + + H E+ + + LY + + ++ Sbjct: 198 HGGHEVDLKEYKEIFDYVRESGVPLSVHAGEDVT-LPNLNTLYSAIQ--VLKVERIG--- 251 Query: 273 NKTVMAHGCYL--SAEELNVFHERGASIAHCPNSNLSLSSG----FLNVLEVLKHEVKIG 326 HG + S E +++ E+ + CP SN+ L + + ++ VK+ Sbjct: 252 ------HGIRVAESQELIDMVKEKNILLEVCPISNVLLKNAKSMDTHPIRQLYDAGVKVS 305 Query: 327 LGTDVAGGYSYSMLDAIRRAVM 348 + +D G + ++ D Sbjct: 306 VNSDDPGMFLTNINDDYEELYT 327 >6II7-A nrPDB Length = 367 Score = 42.1 bits (97), Expect = 4e-04, Method: Composition-based stats. Identities = 25/142 (17%), Positives = 51/142 (35%), Gaps = 18/142 (12%) Query: 213 RFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLT 272 ++ + + + I H E+ S N S+Y NLL Sbjct: 203 HAGHEVDLKPFKDIFDNIREEGISISVHAGEDV-----------SIPNLNSLYTAINLLH 251 Query: 273 NKTVMAHGCYLSAEE--LNVFHERGASIAHCPNSNLSLSS----GFLNVLEVLKHEVKIG 326 K + HG +S + +++ E+ + CP SN+ L++ + + VK+ Sbjct: 252 VKRI-GHGIRVSESQELIDLVKEKDILLEVCPISNVLLNNVKSMDTHPIRMLYDAGVKVS 310 Query: 327 LGTDVAGGYSYSMLDAIRRAVM 348 + +D G + ++ D Sbjct: 311 VNSDDPGMFLTNITDNYEELYT 332 >2AMX-A nrPDB Length = 376 Score = 41.4 bits (95), Expect = 9e-04, Method: Composition-based stats. Identities = 21/109 (19%), Positives = 44/109 (40%), Gaps = 18/109 (16%) Query: 231 KTRDLHIQSHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEE--L 288 + LH+ H E+ N ++Y N+L + + HG +S + + Sbjct: 230 RDHGLHLTVHAGEDAT-----------LPNLNTLYTAINILNVERI-GHGIRVSESDELI 277 Query: 289 NVFHERGASIAHCPNSNLSLSS----GFLNVLEVLKHEVKIGLGTDVAG 333 + ++ + CP SNL L++ + ++ VK+ + +D G Sbjct: 278 ELVKKKDILLEVCPISNLLLNNVKSMDTHPIRKLYDAGVKVSVNSDDPG 326 >2VUN-A nrPDB Length = 386 Score = 41.0 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 56/397 (14%), Positives = 101/397 (25%), Gaps = 65/397 (16%) Query: 28 VLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQ 87 VL+ + V D G I + + + PGL+DTH+H S Sbjct: 21 VLQADTIVVED-GLIAAIGGEELMKDAGDA-------TIIDAAGSTVTPGLLDTHVHVS- 71 Query: 88 YSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTR-VVRRTLKNGTTTACYFATIH 146 D+A T + L G TT + H Sbjct: 72 ----------------------------GGDYAPRQKTMDFISSALHGGVTTMISAGSPH 103 Query: 147 TDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESIKETERFVSE-MLQKNYSR 205 D G +A + + P + ++ + E ++ Sbjct: 104 FPG-----RPKDAAGTKALAITLSKSYYNARPAGVKVHGGAVILEKGLTEEDFIEMKKEG 158 Query: 206 VKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKNLYPSYKNYTSVY 265 V + + + A +Q H + K V Sbjct: 159 VWIVGEVGLGTIKNPEDAAPMVEWAHKHGFKVQMHTGGTSIPGSSTVTADDVIKTKPDVV 218 Query: 266 DKNNLLTNKTVMAHGCY--LSAEELNVFHERGASIAHCPNSNLSLSSGFLNVLEVLKHEV 323 N + + + + I C N ++ Sbjct: 219 SHIN-GGPTAISVQEVDRIMDETDFAM------EIVQC--GNPKIADYVARRAAEKGQLG 269 Query: 324 KIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLD 383 ++ G D G L +R ++++ + + +AT + GL+ Sbjct: 270 RVIFGNDAPSGTGLIPLGILRNMCQIASM--------SDIDPEVAVCMATGNSTAVYGLN 321 Query: 384 GEIGNFEVGKEFDAILINPKASDSPIDLFYGDFFGDI 420 G GKE D I+++ D GDI Sbjct: 322 --TGVIAPGKEADLIIMDTPLGSVAEDAMGAIAAGDI 356 >3E74-A nrPDB Length = 473 Score = 41.0 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 54/424 (12%), Positives = 126/424 (29%), Gaps = 67/424 (15%) Query: 28 VLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQ 87 ++++ + + + ++V + + + E+ + S PG+VD H H S+ Sbjct: 26 IIKNGTVILENEARVVDIAVKGGKIAAIGQDLGDAKEVMDASG-LVVSPGMVDAHTHISE 84 Query: 88 ------------YSFAGSSIDLPLLEW-LTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKN 134 A ++E L + + + F + Sbjct: 85 PGRSHWEGYETGTRAAAKGGITTMIEMPLNQLPATVDRASIELKFDAAKGKLTIDAAQLG 144 Query: 135 GTTTACYFATIHTDSSLLLADITDKFGQRAFVG-KVCMDLNDTFPEYKE----------- 182 G + D L ++ G + FV +++ F + + Sbjct: 145 GLVSYNI------DRLHELDEV-GVVGFKCFVATCGDRGIDNDFRDVNDWQFFKGAQKLG 197 Query: 183 --TTEESIKETERFVSEMLQKNYSRVKPIVTPRFSLSCSE-----TLMGELGNIAKTRDL 235 + + + L + R + VT ++ + + +AK Sbjct: 198 ELGQPVLVHCENALICDELGEEAKR-EGRVTAHDYVASRPVFTEVEAIRRVLYLAKVAGC 256 Query: 236 HIQ-SHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHER 294 + H+S + + VE V ++ T + + + EE+ + Sbjct: 257 RLHVCHVS-SPEGVEEVTRARQEGQDITCESCPHYFVLDTDQF--------EEIGTLAK- 306 Query: 295 GASIAHCPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVA-------GGYSYSMLDAIRRAV 347 C L + ++ E+ L +D + G I Sbjct: 307 ------CSPPIRDLENQKGMWEKLFNGEIDC-LVSDHSPCPPEMKAGNIMKAWGGIAGLQ 359 Query: 348 MVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDS 407 +++ V ++ ++L +L + GL + G GK+ D + I P +S Sbjct: 360 SCMDVMFDEAVQKRGMSLPMFGKLMATNAADIFGLQQK-GRIAPGKDADFVFIQPNSSYV 418 Query: 408 PIDL 411 + Sbjct: 419 LTND 422 >1YNY-A nrPDB Length = 461 Score = 38.7 bits (88), Expect = 0.005, Method: Composition-based stats. Identities = 56/386 (14%), Positives = 112/386 (29%), Gaps = 94/386 (24%) Query: 74 FMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLK 133 +PG +D H H + + R Sbjct: 50 VIPGGIDPHTHLDM--------------------------PFGGTVTADDFFTGTRAAAF 83 Query: 134 NGTTTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESIKETER 193 GTT+ F SL A T R GK +D E ++ ++E E Sbjct: 84 GGTTSIVDFCLTKKGESLKSAIATWHEKAR---GKAVIDYGFHL-MIAEANDQVLEELES 139 Query: 194 FVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKN 253 +S + + +K + + + + + AK +Q H +EN D ++ + Sbjct: 140 VISS---EGITSLKVFMAYKNVFQADDETLFKTLVKAKELGALVQVH-AENGDVLDYLTK 195 Query: 254 ----------LYPSYKNYTSVYDK--------NNLLTNKTVMAHGCYLSAEELNVFHER- 294 +Y +Y + L ++ + H SA + E Sbjct: 196 KALAEGNTDPIYHAYTRPPEAEGEATGRAIALTALAGSQLYVVHVSCASA--VQRIAEAR 253 Query: 295 ----GASIAHCPNSNLSLSSGFLNVLEV-----------------------LKHEVKIGL 327 CP L+L ++ + LK+ + + Sbjct: 254 EKGWNVYGETCPQY-LALDVSIMDQPDFEGAKYVWSPPLREKWNQEVLWSALKNGILQTV 312 Query: 328 GTD-----------VAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATLGG 376 G+D + G + + IL V + ++L + +++ Sbjct: 313 GSDHCPFNFRGQKELGRGDFTKIPNGGPLIEDRLTILYSEGVRQGRISLNQFVDISSTKA 372 Query: 377 SQALGLDGEIGNFEVGKEFDAILINP 402 ++ G+ G VG + D ++ +P Sbjct: 373 AKLFGMFPRKGTIAVGSDADIVIFDP 398 >3IV8-A nrPDB Length = 381 Score = 38.7 bits (88), Expect = 0.006, Method: Composition-based stats. Identities = 18/73 (24%), Positives = 30/73 (41%), Gaps = 8/73 (10%) Query: 329 TDVAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGN 388 D G S L I N V + L E R+ATL ++A+G+D ++G Sbjct: 300 VDENGTLGGSALTMIEAV--------QNTVEHVGIALDEALRMATLYPAKAIGVDEKLGR 351 Query: 389 FEVGKEFDAILIN 401 + G + + + Sbjct: 352 IKKGMIANLTVFD 364 >1GKQ-A nrPDB Length = 458 Score = 37.5 bits (85), Expect = 0.012, Method: Composition-based stats. Identities = 35/222 (15%), Positives = 71/222 (31%), Gaps = 36/222 (16%) Query: 46 EEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTK 105 E ++ + P + ++ PG +D H+H LP + Sbjct: 22 AEGETITRIGQNLEAPPGTEVIDATGKYVFPGFIDPHVHIY----------LPFMA---- 67 Query: 106 YTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTACYFATIHTDSSLLLADITDKFGQRAF 165 FA++ + + L GTTT I D + + Sbjct: 68 ------------TFAKDTHETGSKAALMGGTTT-----YIEMCCPSRNDDALEGYQLWKS 110 Query: 166 VGKVCMDLNDTFPEYKETTEESIKETERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGE 225 + + TF +E +TE + E++ S K ++ + + M + Sbjct: 111 KAEGNSYCDYTFHMAVSKFDE---KTEGQLREIVADGISSFKIFLSYKNFFGVDDGEMYQ 167 Query: 226 LGNIAKTRDLHIQSHISENRDEVEAV-KNLYPSYKNYTSVYD 266 +AK + + +H EN + V + + L K ++ Sbjct: 168 TLRLAKELGVIVTAHC-ENAELVGRLQQKLLSEGKTGPEWHE 208 Score = 37.1 bits (84), Expect = 0.015, Method: Composition-based stats. Identities = 12/53 (22%), Positives = 23/53 (43%) Query: 351 NILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPK 403 N+L V+ L + A+ ++ GL G VG + D ++ +P+ Sbjct: 345 NLLYTYGVSRGRLDIHRFVDAASTKAAKLFGLFPRKGTIAVGSDADLVVYDPQ 397 >3T8L-A nrPDB Length = 608 Score = 36.4 bits (82), Expect = 0.025, Method: Composition-based stats. Identities = 32/180 (17%), Positives = 60/180 (33%), Gaps = 35/180 (19%) Query: 269 NLLTNKTVMAHGCYLSAEELNVFHERGASIAHCPNSNLSLSSGFLNVLEVLKHEVKIGLG 328 L K V H L +LN F G S S+ L SG E L +++ GL Sbjct: 211 GLAAEKLVCGHARGLKNADLNAFMAAGVS------SDHELVSG-----EDLMAKLRAGLT 259 Query: 329 TDVAGGYS---------YSMLDAI-RRAVMVSNILLINKVNEKS-------------LTL 365 ++ G + + L + + + ++ + + + + L Sbjct: 260 IELRGSHDHLLPEFVAALNTLGHLPQTVTLCTDDVFPDDLLQGGGLDDVVRRLVRYGLKP 319 Query: 366 KEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDSPIDLFYGDFFGDISEAVI 425 + R ATL +Q LG ++G G+ D ++ S + ++ Sbjct: 320 EWALRAATLNAAQRLGR-SDLGLIAAGRRADIVVFEDLNGFSARHVLASGRAVAEGGRML 378 >4CEX-C nrPDB Length = 570 Score = 36.4 bits (82), Expect = 0.029, Method: Composition-based stats. Identities = 16/52 (30%), Positives = 23/52 (44%) Query: 352 ILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPK 403 L K + LK T+ + A G+ E+G+ E GK D +L PK Sbjct: 390 PLAEEKNGSDNFRLKRYVSKYTINPAIAQGIAHEVGSIEEGKFADLVLWEPK 441 >2VHL-A nrPDB Length = 396 Score = 36.4 bits (82), Expect = 0.030, Method: Composition-based stats. Identities = 58/409 (14%), Positives = 128/409 (31%), Gaps = 89/409 (21%) Query: 27 EVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHAS 86 EV+++ +G++D GKI + +E +KE P + +PG++D HIH Sbjct: 17 EVIKNGYVGIND-GKISTVSTERPKEPYSKE-IQAPAD-------SVLLPGMIDIHIHG- 66 Query: 87 QYSFAGSSIDLPLLEW-LTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTACYFATI 145 + ++D + P E T ++G + + Sbjct: 67 --GYGADTMDASFSTLDIMSSRLPEEGT---------TSFLATTITQEHGNISQA----L 111 Query: 146 HTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPE---YKETTEESIKETE-RFVSEMLQK 201 A+ + G + + L F +E I+ ++ + Q+ Sbjct: 112 VNAREWKAAEESSLLG----AELLGIHLEGPFVSPKRAGAQPKEWIRPSDVELFKKWQQE 167 Query: 202 NYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKNLYPSYKNY 261 +K + + + I +D I + + + + + + Sbjct: 168 AGGLIKIV-------TLAPEEDQHFELIRHLKDESIIASMGHTDADSALLSDAAKAG--- 217 Query: 262 TSVYDKNNLLTNKTVMAHGCYLSAEELNVFHE----RGASIAHCPNSNLSLSSGF----- 312 +H +L H G ++AH ++ G Sbjct: 218 ---------------ASHMTHLYNAMSPFHHREPGVIGTALAHDGFVTELIADGIHSHPL 262 Query: 313 -LNVLEVLKHEVKIGLGTDVAGGYSY---------SMLDAIRRAVMVSNILLINKV---N 359 + + K K+ L TD + R ++S+ L + N Sbjct: 263 AAKLAFLAKGSSKLILITDSMRAKGLKDGVYEFGGQSVTVRGRTALLSDGTLAGSILKMN 322 Query: 360 EKSLTLKE--------VFRLATLGGSQALGLDGEIGNFEVGKEFDAILI 400 E + ++E + + + ++ LG+ G+ VGK+ D +++ Sbjct: 323 EGARHMREFTNCSWTDIANITSENAAKQLGIFDRKGSVTVGKDADLVIV 371 >5NKS-A nrPDB Length = 573 Score = 36.0 bits (81), Expect = 0.036, Method: Composition-based stats. Identities = 43/266 (16%), Positives = 81/266 (30%), Gaps = 51/266 (19%) Query: 67 ELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTR 126 +H +PG VD H PA+ + + Sbjct: 59 IDAHGLMVLPGGVDVHTRLQMPVLG---------------MTPADD-----------FCQ 92 Query: 127 VVRRTLKNGTTTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEYKETTEE 186 + L GTT + D+ + L +++ +RA C + + + T Sbjct: 93 GTKAALAGGTTMILDH--VFPDTGVSLLAAYEQWRERADSAACC-----DYSLHVDITRW 145 Query: 187 SIKETERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRD 246 E + + +K + + + CS++ M E+ +I + Q H +EN D Sbjct: 146 HESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQMYEIFSIIRDLGALAQVH-AENGD 204 Query: 247 EVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASI---AHCPN 303 VE + + + + H E R +I A+CP Sbjct: 205 IVEEEQK----------RLLELGITGPE---GHVLSHPEEVEAEAVYRAVTIAKQANCPL 251 Query: 304 SNLS-LSSGFLNVLEVLKHEVKIGLG 328 +S G + + K + G Sbjct: 252 YVTKVMSKGAADAIAQAKRRGVVVFG 277 >3IGH-X nrPDB Length = 486 Score = 36.0 bits (81), Expect = 0.040, Method: Composition-based stats. Identities = 10/44 (22%), Positives = 23/44 (52%), Gaps = 1/44 (2%) Query: 358 VNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILIN 401 +++L +K+ T G ++ L +IG E G + + I+++ Sbjct: 429 TKDQALDIKDALHSYTYGSARV-SLASDIGKLEPGFKAEYIILD 471 Score = 32.5 bits (72), Expect = 0.41, Method: Composition-based stats. Identities = 39/285 (13%), Positives = 87/285 (30%), Gaps = 23/285 (8%) Query: 17 FVHSTWTCPMEVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMP 76 ++ T L+ V GK+++ ++ +K+ + EI +L ++ MP Sbjct: 6 LINGTIYTSFNPLKKVSGLVISHGKVIYAGDSEVAKKIVELSGG---EIVDLKG-KYVMP 61 Query: 77 GLVDTHIH-------ASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVR 129 D+H+H G+ L++ L + F D E + Sbjct: 62 AFFDSHLHLDELGMSLEMVDLRGAKSIEELIQRLKRGKGRIIFGF-GWDQDELGEWPTRK 120 Query: 130 RTLKNGTTTACYFATIHTDSSLLLADITDKFGQ---RAFVGKVCMDLNDTFPEYKETTEE 186 N + ++ + + + F + + E ++ E Sbjct: 121 EL--NAIDKPVFIYRKCFHVAVANDKMLELLNLTPSKDFDEDTGIIKEKSLEEARKVINE 178 Query: 187 SIKETERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHIS---E 243 + E +V + + + V +S +E + L + + L I E Sbjct: 179 RVLTVEDYVYYIKRAQEHLLDLGVKSVSFMSVNEKALRALFYLEREGKLSINVFAYVTPE 238 Query: 244 NRDEVEAVKNLYPSYKNYT---SVYDKNNLLTNKTVMAHGCYLSA 285 D++E++ T + L +T + Y Sbjct: 239 VLDKLESIGLGRFQGNRLTIAGVKLFTDGSLGARTALLSKPYSDD 283 >4Z42-C nrPDB Length = 572 Score = 35.2 bits (79), Expect = 0.068, Method: Composition-based stats. Identities = 12/31 (38%), Positives = 19/31 (61%) Query: 373 TLGGSQALGLDGEIGNFEVGKEFDAILINPK 403 T+ + A G+ IG+ EVGK D +L +P+ Sbjct: 413 TINPAIAQGVSHVIGSVEVGKMADLVLWDPR 443 >3MPG-A nrPDB Length = 428 Score = 34.4 bits (77), Expect = 0.097, Method: Composition-based stats. Identities = 69/424 (16%), Positives = 129/424 (30%), Gaps = 96/424 (22%) Query: 35 GVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSH--HEFFMPGLVDTHIHASQYSFAG 92 +++ GKIV + Q K+AK + E+ + PGLVD H+H + Sbjct: 10 YMNEEGKIVATDLLVQDGKIAKVAENITADNAEVIDVNGKLIAPGLVDVHVHLREPG--- 66 Query: 93 SSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTACYFATI--HTDSS 150 EH+ E K G TT C D Sbjct: 67 -----------------GEHK--------ETIETGTLAAAKGGFTTICAMPNTRPVPDCR 101 Query: 151 LLLADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESIKETERFVSEMLQKNYSRVKPIV 210 + D+ ++ ++A V + P T ++ E F + ++ V Sbjct: 102 EHMEDLQNRIKEKAHV--------NVLPYGAITVRQAGSEMTDFETLKELGAFAFTDDGV 153 Query: 211 TPRFSLSCSETLMGELGNIAKTRDLHIQSH-----------ISENRDEVEAVKNLYPSYK 259 + + ++M A ++ + +H + E + + N PS Sbjct: 154 GVQDA-----SMMLAAMKRAAKLNMAVVAHCEENTLINKGCVHEGKFSEKHGLNGIPSVC 208 Query: 260 NYTSVYDKNNLLTNKTVMAHGCYLSAEE----LNVFHERGASI---------AHC----- 301 + L H C++S + + G + C Sbjct: 209 ESVHIARDILLAEAADCHYHVCHVSTKGSVRVIRDAKRAGIKVTAEVTPHHLVLCEDDIP 268 Query: 302 -PNSNLSLSSGFLNVLEVLKHEVKIG---------LGTDVAGGYSYSMLDAIRRA----- 346 + N ++ + HE I + TD A + I RA Sbjct: 269 SADPNFKMNP---PLRGKEDHEALIEGLLDGTIDMIATDHAPHTAEEKAQGIERAPFGIT 325 Query: 347 --VMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKA 404 +L N V + +TL+++ + T + GL E G + G+ D +I+ + Sbjct: 326 GFETAFPLLYTNLVKKGIITLEQLIQFLTEKPADTFGL--EAGRLKEGRTADITIIDLEQ 383 Query: 405 SDSP 408 + Sbjct: 384 EEEI 387 >1RK6-A nrPDB Length = 496 Score = 34.4 bits (77), Expect = 0.12, Method: Composition-based stats. Identities = 8/52 (15%), Positives = 16/52 (30%) Query: 40 GKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQYSFA 91 G++ + + + R + PG +D+H H Y Sbjct: 38 GRLADVGVRGDRIAAVGDLSASSARRRIDVAGKVVSPGFIDSHTHDDNYLLK 89 >5XGX-A nrPDB Length = 395 Score = 34.1 bits (76), Expect = 0.14, Method: Composition-based stats. Identities = 62/410 (15%), Positives = 124/410 (30%), Gaps = 80/410 (19%) Query: 23 TCPMEVLRDHLLGVSD----SGKIVFLEEASQQE-KLAKEWCFKPCEIRELSHHEFFMPG 77 C + + + LG+ D KI + + Q E + K+W K PG Sbjct: 11 LCNVNIYAPNPLGIKDVLIAGNKIAAIYDHGQGEITIPKQWPVKVINF----DGAILTPG 66 Query: 78 LVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTT 137 +D+H H G + FA +V + G T Sbjct: 67 FIDSHAHI--TGGGGQAG-----------------------FATQVPPVGLTEFTHAGVT 101 Query: 138 TACYFATIHTDSSLLLADITDKF------GQRAFVGKVCMDL-NDTFPEYKETTEESIKE 190 T D++ ++ + G A+ T ++ ++ Sbjct: 102 TVVGLLG-TDDTTRSTENLLSRVYGLREEGLSAYCWTGGYHFPLTTITGSAKSDIAFLEP 160 Query: 191 T---ERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDE 247 F + + + ++ + + G+ G I H+ + Sbjct: 161 VIGIGEFAISDHRSSQPTFEEVIRLASETHVAGLITGKAGV--------IHFHLGDGERR 212 Query: 248 VEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAHC--PNSN 305 +E ++ + V++ ++ NK + E+ +G I P Sbjct: 213 LELIERAIRETELPARVFNPTHVNRNKPLF--------EDSCKLLSKGCHIDLTAFPAGT 264 Query: 306 LSLSSGFLNVLEVL-KHEVK---IGLGTDVAG--------GYSYSMLDAIRRAVMVSNIL 353 + +E+ + ++ I L +D G G M RA + L Sbjct: 265 AQPGWEACDAIEMAVERQLPLEQITLSSDGGGCLPCFDPQGELQHM--DFGRASTLGETL 322 Query: 354 LINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPK 403 + K L+L+ V + T + L + G VG + D +++N K Sbjct: 323 VATLN--KGLSLETVLPMLTSNVANILRFKNK-GQIAVGFDADLLVMNEK 369 >4LCQ-A nrPDB Length = 520 Score = 34.1 bits (76), Expect = 0.14, Method: Composition-based stats. Identities = 12/63 (19%), Positives = 21/63 (33%), Gaps = 10/63 (15%) Query: 34 LGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQYSFAGS 93 + + GKIV + + P + +PG +DTH H Sbjct: 45 VHIR-GGKIVEVGP---------DLRVPPGARVIDATDRLVIPGGIDTHTHMELAFMGTR 94 Query: 94 SID 96 ++D Sbjct: 95 AVD 97 >2ICS-A nrPDB Length = 379 Score = 33.7 bits (75), Expect = 0.17, Method: Composition-based stats. Identities = 53/371 (14%), Positives = 114/371 (30%), Gaps = 64/371 (17%) Query: 54 LAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHR 113 +A E L + G +D H+H + Y +P E Sbjct: 32 VAATISGSAKETIHLEPGTYVSAGWIDDHVHCFEKMAL-------------YYDYPDEI- 77 Query: 114 FQNIDFAEEVYTRVVRRTLKNGTTTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMDL 173 + V + GTT A IH L T+ FG + K + Sbjct: 78 ---------GVKKGVTTVIDAGTTGAE---NIHEFYDLAQQAKTNVFGL-VNISKWGIVA 124 Query: 174 NDTFPEYKETTEESIKETERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTR 233 D + + +K+ + + + + +R+ V ++ L ++ + + Sbjct: 125 QDELADLSKVQASLVKKAIQELPDFVVGIKARMSRTVIGDNGITP-LELAKQIQQ--ENQ 181 Query: 234 DLHIQSHISENRDEVEAVKNLYPSYKNYTSVYD--KNNLLTNKTVMAHGCYLSAEELNVF 291 ++ + HI ++ + L T ++ +N +L T +++ F Sbjct: 182 EIPLMVHIGSAPPHLDEILALMEKGDVLTHCFNGKENGILDQAT----------DKIKDF 231 Query: 292 H--ERGASIAHCPNSNLSLSSGF----LNVLE-VLKHEVKIG-LGTDVAGGYSYSMLDAI 343 + + G +V E L+ +K + TD+ + + Sbjct: 232 AWQAYNKGVV------FDIGHGTDSFNFHVAETALREGMKAASISTDIYIRNREN--GPV 283 Query: 344 RRAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPK 403 L + + E+ T ++ L + G E+GK+ D + + Sbjct: 284 YDLATTMEKLRVVGYDWP-----EIIEKVTKAPAENFHLTQK-GTLEIGKDADLTIFTIQ 337 Query: 404 ASDSPIDLFYG 414 A + + G Sbjct: 338 AEEKTLTDSNG 348 >1E9Y-B nrPDB Length = 569 Score = 33.3 bits (74), Expect = 0.25, Method: Composition-based stats. Identities = 14/50 (28%), Positives = 24/50 (48%) Query: 353 LLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINP 402 L K + + +K T+ + A G+ +G+ EVGK D +L +P Sbjct: 390 LKEEKGDNDNFRIKRYLSKYTINPAIAHGISEYVGSVEVGKVADLVLWSP 439 >4H9M-A nrPDB Length = 840 Score = 32.9 bits (73), Expect = 0.28, Method: Composition-based stats. Identities = 11/59 (18%), Positives = 24/59 (40%) Query: 345 RAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPK 403 + + L + + + ++ T+ + A G +G+ EVGK D ++ P Sbjct: 653 KMKAQTGPLKCDSSDNDNFRIRRYIAKYTINPAIANGFSQYVGSVEVGKLADLVMWKPS 711 >3SFW-A nrPDB Length = 461 Score = 32.9 bits (73), Expect = 0.33, Method: Composition-based stats. Identities = 58/425 (13%), Positives = 122/425 (28%), Gaps = 93/425 (21%) Query: 34 LGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQYSFAGS 93 + SD+ + L + + + + E+ + + + + +PG +D H H Sbjct: 11 VTASDTYQADVLIDGEKVVAIGSDLQATDAEVIDATGY-YLLPGGIDPHTHLDM------ 63 Query: 94 SIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTACYFATIHTDSSLLL 153 + + + GTT+ F SL Sbjct: 64 --------------------PFGGTVTSDNFFTGTKAAAFGGTTSIVDFCLTSKGESLHS 103 Query: 154 ADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESIKETERFVSEMLQKNYSRVKPIVTPR 213 A T R GK +D + + ++E E V+ + + +K + + Sbjct: 104 AIATWHEKAR---GKAVIDYGFHL-MVSDANDHVLEELESVVN---NEGITSLKVFMAYK 156 Query: 214 FSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKN----------LYPSYKNYTS 263 L + + + AK +Q H +EN D ++ + +Y +Y Sbjct: 157 NVLMADDETLFKTLIRAKELGALVQVH-AENGDVLDYLTKQALAEGNTDPIYHAYTRPPE 215 Query: 264 VYDK--------NNLLTNKTVMAHGCYLSAEELNVFHER-----GASIAHCPN------- 303 + L + + H A + E CP Sbjct: 216 AEGEATGRAIALTALADAQLYVVHVSCADA--VRRIAEAREKGWNVYGETCPQYLVLDIT 273 Query: 304 ----SNLSLSSGFL--NVLEVL---------KHEVKIGLGTDVAGGYSYSMLDAIRRAVM 348 + + + E K+ + +G+D + RR Sbjct: 274 ALEKPDFEGAKYVWSPPLREKWNQDVLWSALKNGILQTVGSDHCPFNFSGQKELGRRDFT 333 Query: 349 -----------VSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDA 397 IL V + ++L + + + ++ G+ + G VG + D Sbjct: 334 KIPNGGPIIEDRMTILFSEGVRKGKISLNQFVDITSTKVAKLFGMFPQKGTIAVGSDADI 393 Query: 398 ILINP 402 +L +P Sbjct: 394 VLFDP 398 >3S9V-A nrPDB Length = 785 Score = 32.5 bits (72), Expect = 0.40, Method: Composition-based stats. Identities = 18/133 (13%), Positives = 36/133 (27%), Gaps = 8/133 (6%) Query: 170 CMDLNDTFPEYKETTEESIKETERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNI 229 M L + + + R ++ + V L L + Sbjct: 218 IMKLQSKDGSFLSSPASTAAVFMRTGNKKCLDFLNFVLKKFGNHVPCHYPLDLFERLWAV 277 Query: 230 AKTRDLHIQSHISENRDEVEAV-------KNLYPSYKNYTSVYDKNNLLTNKTVMAHGCY 282 L I H E E + + + +N D + + + HG Sbjct: 278 DTVERLGIDRHFKEEIKEALDYVYSHWDERGIGWARENPVPDIDDTA-MGLRILRLHGYN 336 Query: 283 LSAEELNVFHERG 295 +S++ L F + Sbjct: 337 VSSDVLKTFRDEN 349 >4G7E-B nrPDB Length = 840 Score = 32.5 bits (72), Expect = 0.41, Method: Composition-based stats. Identities = 12/59 (20%), Positives = 22/59 (37%) Query: 345 RAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPK 403 + L + + +K T+ + A G +G+ EVGK D ++ P Sbjct: 653 KMKSARGPLQPGEEANDNFRIKRYVAKYTINPAIANGFSQYVGSVEVGKLADLVMWKPS 711 >3TAC-A nrPDB Length = 361 Score = 32.5 bits (72), Expect = 0.44, Method: Composition-based stats. Identities = 39/272 (14%), Positives = 76/272 (27%), Gaps = 14/272 (5%) Query: 25 PMEVLR---DHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDT 81 P V+R + G + KIV + + + L+ E + I + H + L Sbjct: 38 PFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKHPHIVELLETY 97 Query: 82 HIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTACY 141 Y L + A+ F + Y R + L+ Sbjct: 98 SSDGMLYMVFEFMDGADLC---FEIVKRADAGFVYSEAVASHYMRQILEALRYCHDNNII 154 Query: 142 FATIHTDSSLLLADI------TDKFGQRAFVGKVCMDLNDTFPEYKETTEESIKETERFV 195 + LL + FG +G+ + E +K Sbjct: 155 HRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFMAPEVVKREPYGK 214 Query: 196 SEMLQKNYSRVKPIVTPRFS-LSCSETLMGELGNIAKTRDLHIQSHISENRDE-VEAVKN 253 + + +++ E L + + SHISE+ + V + Sbjct: 215 PVDVWGCGVILFILLSGCLPFYGTKERLFEGIIKGKYKMNPRQWSHISESAKDLVRRMLM 274 Query: 254 LYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSA 285 L P+ + + L + A+ +L Sbjct: 275 LDPAERITVYEALNHPWLKERDRYAYKIHLPE 306 >4OTK-A nrPDB Length = 318 Score = 32.1 bits (71), Expect = 0.58, Method: Composition-based stats. Identities = 18/78 (23%), Positives = 33/78 (42%), Gaps = 2/78 (2%) Query: 370 RLATLGGSQALGLDGEIGNFEVG-KEFDAILINPKASDSPIDLFYGDFFGDISEAVIQKF 428 +A++ G Q +G E E G +I +N + + + L + D +E + Sbjct: 20 HMASMTGGQQMGRGSEFVTGESGAAAAPSITLNDEHTMPVLGLGVAELSDDETERAVSAA 79 Query: 429 LYLGDDRNIEEVYVGGKQ 446 L +G R I+ Y G + Sbjct: 80 LEIG-CRLIDTAYAYGNE 96 >1FWC-C nrPDB Length = 567 Score = 31.7 bits (70), Expect = 0.70, Method: Composition-based stats. Identities = 13/58 (22%), Positives = 25/58 (43%) Query: 345 RAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINP 402 R + L + + +K T+ + G+ E+G+ EVGK D ++ +P Sbjct: 380 RMKVQRGALAEETGDNDNFRVKRYIAKYTINPALTHGIAHEVGSIEVGKLADLVVWSP 437 >3QGK-C nrPDB Length = 568 Score = 31.7 bits (70), Expect = 0.75, Method: Composition-based stats. Identities = 13/50 (26%), Positives = 22/50 (44%) Query: 353 LLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINP 402 L K + + +K T+ + G+ IG+ E GK D ++ NP Sbjct: 389 LTEEKGDNDNFRIKRYISKYTINPAITHGVSEYIGSVEEGKIADLVVWNP 438 >4TQT-A nrPDB Length = 497 Score = 31.4 bits (69), Expect = 0.92, Method: Composition-based stats. Identities = 33/220 (15%), Positives = 65/220 (29%), Gaps = 49/220 (22%) Query: 34 LGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQYSFAGS 93 + + D GKI + ++ + + + + MPG +D H H Sbjct: 34 ILIED-GKIAAIGDSLE------------GDEVIDASGCYVMPGGIDPHTHLQM------ 74 Query: 94 SIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTACYFATIHTDSSLLL 153 P + ++ + + L GTT F + DS L Sbjct: 75 ----PFM----------------GTYSSDDFDTGTAAALAGGTTMVVDF--VLPDSEGNL 112 Query: 154 ADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESIKETERFVSEMLQKNYSRVKPIVTPR 213 D ++ Q+A + + + E + E V + K + + Sbjct: 113 LDALQEWFQKAGKARTDYSFHMAITGWNE---RTFNEMAEVVKRGINT----FKHFMAYK 165 Query: 214 FSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKN 253 +L ++ M H +EN D V ++ Sbjct: 166 GALMVNDDEMFASFQRCAELGAMPLVH-AENGDIVAQLQA 204 Score = 28.7 bits (62), Expect = 5.6, Method: Composition-based stats. Identities = 10/57 (17%), Positives = 23/57 (40%) Query: 352 ILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDSP 408 +L V LT E + + ++ L + + G G + D ++ +P+ + Sbjct: 357 VLWTRGVRTGRLTPNEFVAVTSTNIAKILNIYPQKGAVVPGADADLVIWDPETTKKI 413 >1K1D-A nrPDB Length = 460 Score = 31.4 bits (69), Expect = 0.93, Method: Composition-based stats. Identities = 59/441 (13%), Positives = 122/441 (27%), Gaps = 99/441 (22%) Query: 17 FVHSTWTCPMEVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMP 76 + + + L + D GKI + + +++ + + P Sbjct: 4 IIKNGTIVTATDTYEAHLLIKD-GKIAMIGQNLEEKGAE----------VIDAKGCYVFP 52 Query: 77 GLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGT 136 G +D H H ++ + GT Sbjct: 53 GGIDPHTHLDM--------------------------PLGGTVTKDDFESGTIAAAFGGT 86 Query: 137 TTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESIKETERFVS 196 TT F + L I + GK +D E T++ ++E + + Sbjct: 87 TTIIDFC-LTNKGEPLKKAIETWHNKAN--GKAVIDYGFHL-MISEITDDVLEELPKVLE 142 Query: 197 EMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKN--- 253 E + + +K + + + + AK + H +EN D ++ + Sbjct: 143 E---EGITSLKVFMAYKNVFQADDGTLYCTLLAAKELGALVMVH-AENGDVIDYLTKKAL 198 Query: 254 -------LYPSYKNYTSV--------YDKNNLLTNKTVMAHGCYLSA-EELNVFHERGAS 297 +Y + + L ++ + H A E++ +G Sbjct: 199 ADGNTDPIYHALTRPPELEGEATGRACQLTELAGSQLYVVHVTCAQAVEKIAEARNKGLD 258 Query: 298 I--AHCPN-----------SNLSLSSGFL--NVLEVLKHEVKI---------GLGTDVAG 333 + CP N + + E EV LG+D Sbjct: 259 VWGETCPQYLVLDQSYLEKPNFEGAKYVWSPPLREKWHQEVLWNALKNGQLQTLGSDQCS 318 Query: 334 GYSYSMLDAIRRAVM-----------VSNILLINKVNEKSLTLKEVFRLATLGGSQALGL 382 + R +IL V + +TL + + + ++ GL Sbjct: 319 FDFKGQKELGRGDFTKIPNGGPIIEDRVSILFSEGVKKGRITLNQFVDIVSTRIAKLFGL 378 Query: 383 DGEIGNFEVGKEFDAILINPK 403 + G VG + D ++ +P Sbjct: 379 FPKKGTIVVGSDADLVIFDPN 399 >6HAW-A nrPDB Length = 438 Score = 31.0 bits (68), Expect = 1.3, Method: Composition-based stats. Identities = 10/41 (24%), Positives = 15/41 (36%) Query: 240 HISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHG 280 H+S + A L S++ + Y LL V H Sbjct: 282 HLSSPLASIAATNKLCQSFQTFNICYADTGLLGAHFVCDHM 322 >3DC8-A nrPDB Length = 490 Score = 30.6 bits (67), Expect = 1.3, Method: Composition-based stats. Identities = 60/444 (13%), Positives = 115/444 (25%), Gaps = 96/444 (21%) Query: 16 TFVHSTWTCPMEVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFM 75 T + ++ + V G+IV + + + + M Sbjct: 3 TVIKGGTIVTADLTYKADVKVE-GGRIVEIGPNLSGAETLD------------ATGCYVM 49 Query: 76 PGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNG 135 PG +D H H P + ++ + + R L G Sbjct: 50 PGGIDPHTHLEM----------PFMG----------------TYSSDDFESGTRAALAGG 83 Query: 136 TTTACYFA-TIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESIKETERF 194 TT FA S L + D RA + E E+I + + Sbjct: 84 TTMVVDFALPSPGQSLLEALTMWDNKSTRANCDYSFHMAITWWGEQVFNEMETIVKDKGI 143 Query: 195 VSEML------------QKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQS--- 239 + + +S + + + S Sbjct: 144 NTFKHFMAYKGALMVDDDEMFSSFQRCAALGALPLVHAENGDVVAQLQAKLLAEGNSGPE 203 Query: 240 -HISENRDEVEA----------------VKNLYPSYKNYTSVYDKNNLLTNKTVMAHGC- 281 H EVE V ++ S + + + Sbjct: 204 AHAYSRPAEVEGEAANRAIMIADMAGCPVYIVHTSCEQAHEAIRRARAKGMRVFGEPLIQ 263 Query: 282 YLSAEELNVFHE----RGASIAHCPNSN--------LSLSSGFLNV-----LEVLKHEVK 324 +L+ +E F + + P N L+SG L V + + Sbjct: 264 HLTLDETEYFDKDWDHAARRVMSPPFRNKLHQDSLWAGLASGSLQVVATDHCAFTTEQKR 323 Query: 325 IGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDG 384 G+G L+ +L V +T+ E + + ++ L + Sbjct: 324 FGVGDFTRIPNGTGGLED------RMPMLWTYGVATGRITMNEFVAVTSTNIAKILNIYP 377 Query: 385 EIGNFEVGKEFDAILINPKASDSP 408 + G VG + D ++ +PK S + Sbjct: 378 KKGAILVGADADLVVWDPKRSKTI 401 >6N91-A nrPDB Length = 340 Score = 30.6 bits (67), Expect = 1.5, Method: Composition-based stats. Identities = 15/104 (14%), Positives = 30/104 (28%), Gaps = 17/104 (16%) Query: 231 KTRDLHIQSHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNV 290 + LH+ H E + + + + H + ++ Sbjct: 188 RDAGLHVTVHAGEAAGPESMWQAIRDLGATR---------IGHGVKAIH----DPKLMDY 234 Query: 291 FHERGASIAHCPNSNLSLSS----GFLNVLEVLKHEVKIGLGTD 330 + I C SNL S+ + L+H + + TD Sbjct: 235 LAQHRIGIESCLTSNLQTSTVDSLATHPLKRFLEHGILACINTD 278 >3R64-A nrPDB Length = 508 Score = 30.2 bits (66), Expect = 1.8, Method: Composition-based stats. Identities = 18/106 (16%), Positives = 37/106 (34%), Gaps = 11/106 (10%) Query: 295 GASIAHCPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILL 354 G ++ P S+ ++ G + + V G+ + VAG S I + + Sbjct: 176 GNAVVIKPASDTPVTGGVIPARIFEEAGVPAGVISTVAGAGS-----EIGDHFVTHAVPK 230 Query: 355 INKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILI 400 + + + V LA GG + E+G +++ Sbjct: 231 LISFTGSTPVGRRVGELAINGG------PMKTVALELGGNAPFVVL 270 >1GKR-A nrPDB Length = 458 Score = 30.2 bits (66), Expect = 1.9, Method: Composition-based stats. Identities = 13/61 (21%), Positives = 25/61 (40%), Gaps = 2/61 (3%) Query: 26 MEVLRDHLLGVSDSGKIVF--LEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHI 83 +V+ + VS G L + + ++ + + +F MPG+VD H+ Sbjct: 2 FDVIVKNCRLVSSDGITEADILVKDGKVAAISADTSDVEASRTIDAGGKFVMPGVVDEHV 61 Query: 84 H 84 H Sbjct: 62 H 62 >4YHJ-A nrPDB Length = 584 Score = 29.8 bits (65), Expect = 2.3, Method: Composition-based stats. Identities = 24/135 (17%), Positives = 46/135 (34%), Gaps = 10/135 (7%) Query: 181 KETTEESIKETERFVSEMLQKNYSRVKPIVT--PRFSLSCSETLMGELGNIAKTRDLHIQ 238 +E + +TE + + + S + ++T P L C + +D+ Sbjct: 396 EEVDQRIKNDTEEYSEKFSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDI--- 452 Query: 239 SHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASI 298 N +EA P + +VY K+ L + + G YL + + + Sbjct: 453 -----NFRRLEANMLEPPFCPDPHAVYCKDVLDIEQFSVVKGIYLDTADEDFYARFATGC 507 Query: 299 AHCPNSNLSLSSGFL 313 P N + SG Sbjct: 508 VSIPWQNEMIESGCF 522 >3CKY-A nrPDB Length = 301 Score = 29.4 bits (64), Expect = 3.0, Method: Composition-based stats. Identities = 25/122 (20%), Positives = 45/122 (36%), Gaps = 22/122 (18%) Query: 286 EELNVFHERGASIAHCPNSNLSLSSGFLNVLEVLKHEVKIGLGTDV-------AGGYSYS 338 +++ + GA A +NL L ++ E L VK GL + + G SY+ Sbjct: 159 KDIYHVGDTGAGDAVKIVNNLLLGCNMASLAEALVLGVKCGLKPETMQEIIGKSSGRSYA 218 Query: 339 MLDAIRRAVMVSNILLINKVNEKSLTLKEVFR-------------LAT--LGGSQALGLD 383 M + + +M + ++ + L +AT G +A+GL Sbjct: 219 MEAKMEKFIMSGDFAGGFAMDLQHKDLGLALEAGKEGNVPLPMTAMATQIFEGGRAMGLG 278 Query: 384 GE 385 E Sbjct: 279 RE 280 >1C8N-A nrPDB Length = 276 Score = 29.4 bits (64), Expect = 3.1, Method: Composition-based stats. Identities = 13/62 (20%), Positives = 26/62 (41%), Gaps = 2/62 (3%) Query: 102 WLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTACYFATIHTDSSLLLADITDKFG 161 W+T+ ++ A A T+ + R ++ G + A F T +++ +FG Sbjct: 26 WVTEASWRAGQAPNKERAA--TVTKSIARKVRGGVSRAGGFVTAPVIGAMVTRPTVPRFG 83 Query: 162 QR 163 R Sbjct: 84 MR 85 >2VR2-A nrPDB Length = 541 Score = 29.4 bits (64), Expect = 3.2, Method: Composition-based stats. Identities = 49/309 (15%), Positives = 90/309 (29%), Gaps = 47/309 (15%) Query: 60 FKPCEIREL-SHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNID 118 P +R L + + +PG +DTH H Q+ F GS ++ID Sbjct: 66 GAPAGLRVLDAAGKLVLPGGIDTHTHM-QFPFMGS---------------------RSID 103 Query: 119 FAEEVYTRVVRRTLKNGTTTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFP 178 + L GTT FA SL+ A T + V + Sbjct: 104 DFHQGTKAA----LSGGTTMIIDFAIPQKGGSLIEAFETWRSWADPKVCC-------DYS 152 Query: 179 EYKETTEESIKETERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQ 238 + T S + E + K + K + + ++ + E + K Q Sbjct: 153 LHVAVTWWSDQVKEEMKILVQDKGVNSFKMFMAYKDLYMVTDLELYEAFSRCKEIGAIAQ 212 Query: 239 SHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASI 298 H +EN D + ++ E + AS Sbjct: 213 VH-AENGDLIA-------EGAKKMLALGITGPEGHELCRPEAV---EAEATLRAITIASA 261 Query: 299 AHCPNSNLS-LSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDA-IRRAVMVSNILLIN 356 +CP + +S V+ + + K+ G +A + ++ ++ Sbjct: 262 VNCPLYIVHVMSKSAAKVIADARRDGKVVYGEPIAASLGTDGTHYWNKEWHHAAHHVMGP 321 Query: 357 KVNEKSLTL 365 + T Sbjct: 322 PLRPDPSTP 330 >1SQH-A nrPDB Length = 312 Score = 29.4 bits (64), Expect = 3.3, Method: Composition-based stats. Identities = 12/93 (12%), Positives = 30/93 (32%), Gaps = 11/93 (11%) Query: 37 SDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQYSFAGSSID 96 SD+G+++ + L E R L A+ + Sbjct: 217 SDTGELIAWIFQNDFSGLGMLQVLPKAERRGLGGLLA-----------AAMSREIARGEE 265 Query: 97 LPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVR 129 + L W+ + +E + I + +++ ++ Sbjct: 266 ITLTAWIVATNWRSEALLKRIGYQKDLVNEWIK 298 >5NSQ-A nrPDB Length = 521 Score = 29.0 bits (63), Expect = 3.9, Method: Composition-based stats. Identities = 16/86 (18%), Positives = 32/86 (37%), Gaps = 3/86 (3%) Query: 333 GGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNF--- 389 G + +++ +V + + NE S T V +ATL G+Q + Sbjct: 361 SGKTVEVINTDAEGRIVLGDGVFHATNELSFTPDVVIDMATLTGAQGIATGRHHAGLYVN 420 Query: 390 EVGKEFDAILINPKASDSPIDLFYGD 415 E G E + ++ ++ + Y Sbjct: 421 EEGAEAAMLRAGRESGETCFPVLYCP 446 >3GIQ-A nrPDB Length = 480 Score = 29.0 bits (63), Expect = 4.0, Method: Composition-based stats. Identities = 42/227 (18%), Positives = 60/227 (26%), Gaps = 35/227 (15%) Query: 34 LGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQYSFAGS 93 LGV D G+I + E + + PG +D H H Sbjct: 29 LGVRD-GRIAAIGELGAHPARHAW----------DASGKIVAPGFIDVHGHDDLMFV--- 74 Query: 94 SIDLPLLEWLTK----YTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTACYFATIHTDS 149 + P L W T T L FA + Sbjct: 75 --EKPDLRWKTSQGITTVVVGNCGVSAAPAPLPGNTAAALALLGE----TPLFADVPAYF 128 Query: 150 SLLLADITDKFGQRAFVGKVCMDLND-TFPEYKETTEESIKETERFVSEMLQKNYSRVKP 208 + L A A VG + L P+ T E ++ + +MLQ Sbjct: 129 AALDAQ-RPMINVAALVGHANLRLAAMRDPQAAPTAAE-----QQAMQDMLQAALEAGAV 182 Query: 209 IVTPRFSLSCSETL----MGELGNIAKTRDLHIQSHISENRDEVEAV 251 + + + L +A R SHI D VEA Sbjct: 183 GFSTGLAYQPGAVAQAAELEGLARVAAERRRLHTSHIRNEADGVEAA 229 >6D8G-A nrPDB Length = 886 Score = 29.0 bits (63), Expect = 4.2, Method: Composition-based stats. Identities = 15/81 (18%), Positives = 29/81 (35%), Gaps = 3/81 (3%) Query: 113 RFQNIDFAEEVYTRVVRRTLKNGTTTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMD 172 + E++ R + G D+ L ++ DK G A+ +D Sbjct: 333 KPIGPALTAEMHRRDFLLMKEMGANFIRISHYPQADA---LLEMCDKLGMLAWEEIPIID 389 Query: 173 LNDTFPEYKETTEESIKETER 193 + P Y + E +++E R Sbjct: 390 IVPNTPGYGDNCERNLREMIR 410 >4OJZ-A nrPDB Length = 736 Score = 28.7 bits (62), Expect = 5.2, Method: Composition-based stats. Identities = 16/68 (23%), Positives = 28/68 (41%) Query: 314 NVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLAT 373 N+ + V + + D GGY++ +A+ + L +EK LT + LA Sbjct: 63 NLDAFMAEGVVVPMPKDAGGGYTHEQHKRNYKAIRNAGFLYQVTGDEKYLTFAKDLLLAY 122 Query: 374 LGGSQALG 381 +LG Sbjct: 123 AKMYPSLG 130 >1BEV-3 nrPDB Length = 242 Score = 28.7 bits (62), Expect = 6.0, Method: Composition-based stats. Identities = 28/179 (15%), Positives = 54/179 (30%), Gaps = 7/179 (3%) Query: 46 EEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTK 105 S Q E C E F+PG V+ + +Q + + +E + + Sbjct: 7 GPGSYQFMTTDEDCSPCILPDFQPTPEIFIPGKVNNLLEIAQVESILEANNREGVEGVER 66 Query: 106 YTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTACYFATIHTDSSLLLADITDK---FGQ 162 Y P + D + + +G ++ T+ + + G Sbjct: 67 YVIPVSVQ----DALDAQIYALRLELGGSGPLSSSLLGTLAKHYTQWSGSVEITCMFTGT 122 Query: 163 RAFVGKVCMDLNDTFPEYKETTEESIKETERFVSEMLQKNYSRVKPIVTPRFSLSCSET 221 GKV + + EE++ T LQ + + V P ++ S Sbjct: 123 FMTTGKVLLAYTPPGGDMPRNREEAMLGTHVIWDFGLQSSITLVIPWISASHFRGVSND 181 >5YZA-A nrPDB Length = 525 Score = 28.3 bits (61), Expect = 7.0, Method: Composition-based stats. Identities = 7/57 (12%), Positives = 21/57 (36%) Query: 352 ILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDSP 408 ++ V + + + + ++ L G VG + D ++ +P + + Sbjct: 364 VIWDKAVVTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTI 420 >4NML-A nrPDB Length = 275 Score = 28.3 bits (61), Expect = 7.8, Method: Composition-based stats. Identities = 14/82 (17%), Positives = 30/82 (36%), Gaps = 2/82 (2%) Query: 301 CPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNE 360 P + G+ V ++ +K+GLGT + + + + ++L + Sbjct: 2 NPQDKAKQAVGYFAVDTYVRSGMKVGLGTGTTAKFVVERIGQRMQEGSLKDLLCVPTSEA 61 Query: 361 KSLTLKEV-FRLATLGG-SQAL 380 + + L TL G + L Sbjct: 62 TRKQAESLGIPLTTLDGIADCL 83 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.311 0.119 0.295 Lambda K H 0.267 0.0362 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 14,357,205 Number of Sequences: 36641 Number of extensions: 501498 Number of successful extensions: 1861 Number of sequences better than 10.0: 87 Number of HSP's better than 10.0 without gapping: 75 Number of HSP's successfully gapped in prelim test: 43 Number of HSP's that attempted gapping in prelim test: 1609 Number of HSP's gapped (non-prelim): 161 length of query: 454 length of database: 10,336,785 effective HSP length: 100 effective length of query: 354 effective length of database: 6,672,685 effective search space: 2362130490 effective search space used: 2362130490 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.5 bits) S2: 60 (27.9 bits)