BLASTP 2.2.23 [Feb-03-2010]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Reference for compositional score matrix adjustment: Altschul, Stephen F.,
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.
Reference for composition-based statistics starting in round 2:
Schaffer, Alejandro A., L. Aravind, Thomas L. Madden,
Sergei Shavirin, John L. Spouge, Yuri I. Wolf,
Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005.
Query= Q9Y2T3
(454 letters)
Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta
36,641 sequences; 10,336,785 total letters
Searching..................................................done
Results from round 1
Score E
Sequences producing significant alignments: (bits) Value
3E0L-A nrPDB 926 0.0
2I9U-A nrPDB 259 2e-69
2OOD-A nrPDB 169 2e-42
4DYK-A nrPDB 137 9e-33
4DZH-A nrPDB 135 2e-32
4F0R-A nrPDB 120 1e-27
3LNP-A nrPDB 120 1e-27
3HPA-A nrPDB 83 2e-16
2PAJ-A nrPDB 78 8e-15
2PLM-A nrPDB 75 6e-14
4V1Y-A nrPDB 74 1e-13
4LH8-A nrPDB 59 5e-09
3V7P-A nrPDB 55 7e-08
2IMR-A nrPDB 46 4e-05
4F0L-A nrPDB 43 3e-04
1YRR-A nrPDB 32 0.46
3IV8-A nrPDB 32 0.56
3MKV-A nrPDB 31 1.2
2P9B-A nrPDB 30 1.6
3IEQ-A nrPDB 30 2.3
5XJN-A nrPDB 30 2.7
2XP1-A nrPDB 28 7.7
2XDQ-A nrPDB 28 9.6
4WHB-E nrPDB 28 9.8
>3E0L-A nrPDB
Length = 455
Score = 926 bits (2392), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 448/454 (98%), Positives = 448/454 (98%), Gaps = 2/454 (0%)
Query: 1 MCAAQMPPLAHIFRGTFVHSTWTCPMEVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCF 60
MCAAQMPPLAHIFRGTFVHSTWTCPMEVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCF
Sbjct: 4 MCAAQMPPLAHIFRGTFVHSTWTCPMEVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCF 63
Query: 61 KPCEIRELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFA 120
KPCEIRELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFA
Sbjct: 64 KPCEIRELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFA 123
Query: 121 EEVYTRVVRRTLKNGTTTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEY 180
EEVYTRVVRRTLKNGTTTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEY
Sbjct: 124 EEVYTRVVRRTLKNGTTTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEY 183
Query: 181 KETTEESIKETERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSH 240
KETTEESIKETERFVSEMLQKNYSRVKPIVTP SETLMGELGNIAKTRDLHIQSH
Sbjct: 184 KETTEESIKETERFVSEMLQKNYSRVKPIVTP--GNGVSETLMGELGNIAKTRDLHIQSH 241
Query: 241 ISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAH 300
ISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAH
Sbjct: 242 ISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAH 301
Query: 301 CPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNE 360
CPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNE
Sbjct: 302 CPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNE 361
Query: 361 KSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDSPIDLFYGDFFGDI 420
KSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDSPIDLFYGDFFGDI
Sbjct: 362 KSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDSPIDLFYGDFFGDI 421
Query: 421 SEAVIQKFLYLGDDRNIEEVYVGGKQVVPFSSSV 454
SEAVIQKFLYLGDDRNIEEVYVGGKQVVPFSSSV
Sbjct: 422 SEAVIQKFLYLGDDRNIEEVYVGGKQVVPFSSSV 455
>2I9U-A nrPDB
Length = 439
Score = 259 bits (662), Expect = 2e-69, Method: Compositional matrix adjust.
Identities = 167/444 (37%), Positives = 249/444 (56%), Gaps = 37/444 (8%)
Query: 12 IFRGTFVHSTWTCPMEVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPC-EIRELSH 70
IF+G + + + +++D + V D GKI AS L ++ P + R
Sbjct: 12 IFKGNLIFTKTSDKFTIMKDSYIVVID-GKI-----ASVSSNLPDKYKGNPIIDFR---- 61
Query: 71 HEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRR 130
+ +PG+ D H HASQY G +D LL WL YTFP E +F N+D+A++ Y R+++
Sbjct: 62 NNIIIPGMNDLHAHASQYKNLGIGMDKELLPWLNNYTFPEEAKFLNVDYAKKTYGRLIKD 121
Query: 131 TLKNGTTTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEY-KETTEESIK 189
+KNGTT FAT+H DS++ L ++ K G A+VGKV MD N P+Y E S+
Sbjct: 122 LIKNGTTRVALFATLHKDSTIELFNMLIKSGIGAYVGKVNMDYN--CPDYLTENYITSLN 179
Query: 190 ETERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVE 249
+TE + + K+ + VKPI+TPRF SCS LM LG ++ L +QSH+SEN DE+
Sbjct: 180 DTEEIILKYKDKS-NIVKPIITPRFVPSCSNELMDGLGKLSYKYRLPVQSHLSENLDEIA 238
Query: 250 AVKNLYPSYKNYTSVYDKNNLLTNK-TVMAHGCYLSAEELNVFHERGASIAHCPNSNLSL 308
VK+L+ Y VYDK L N T+MAH + S EE+N+ +I HCP SN +L
Sbjct: 239 VVKSLHKKSNFYGEVYDKFGLFGNTPTLMAHCIHSSKEEINLIKRNNVTIVHCPTSNFNL 298
Query: 309 SSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNEKS-----L 363
SG + V + L + + LG+D++ G++ S+ I A+ S I K E L
Sbjct: 299 GSGMMPVRKYLNLGINVVLGSDISAGHTCSLFKVIAYAIQNSKI----KWQESGKKDMFL 354
Query: 364 TLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDSPIDLFYGDFFGDISEA 423
+ E F +AT G G++G+FE G +FDA++IN DS +L+ D+ D++E
Sbjct: 355 STSEAFYMATKKGGSFF---GKVGSFEEGYDFDALVIN----DS--NLYPEDY--DLTER 403
Query: 424 VIQKFLYLGDDRNIEEVYVGGKQV 447
+++F+YLGDDRNI + YV G ++
Sbjct: 404 -LERFIYLGDDRNIMKRYVCGNEI 426
>2OOD-A nrPDB
Length = 475
Score = 169 bits (428), Expect = 2e-42, Method: Compositional matrix adjust.
Identities = 121/406 (29%), Positives = 193/406 (47%), Gaps = 29/406 (7%)
Query: 67 ELSH--HEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVY 124
E++H +PG +D HIH Q G+ + LL WL K +P E ++++ ++A E
Sbjct: 62 EITHIKDRIIVPGFIDGHIHLPQTRVLGAYGEQ-LLPWLQKSIYPEEIKYKDRNYAREGV 120
Query: 125 TRVVRRTLKNGTTTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEYKETT 184
R + L GTTT F + ++ L + + R G +D N E+ +T
Sbjct: 121 KRFLDALLAAGTTTCQAFTSSSPVATEELFEEASRRNMRVIAGLTGIDRNAP-AEFIDTP 179
Query: 185 EESIKETERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTR-DLHIQSHISE 243
E ++++R +++ K R +TPRF+ S L+ + D + +HISE
Sbjct: 180 ENFYRDSKRLIAQYHDK--GRNLYAITPRFAFGASPELLKACQRLKHEHPDCWVNTHISE 237
Query: 244 NRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAHCPN 303
N E V +P ++Y VY+K +L+ K HG YLS E ++GA++ CP
Sbjct: 238 NPAECSGVLVEHPDCQDYLGVYEKFDLVGPKFSGGHGVYLSNNEFRRMSKKGAAVVFCPC 297
Query: 304 SNLSLSSGFLNVLEVL--KHEVKIGLGTDVAGGYSYSM---LDAIRRAVMVSNILLINKV 358
SNL L SG + +H VK+ GTDV GG +SM LD + M +N LL +
Sbjct: 298 SNLFLGSGLFRLGRATDPEHRVKMSFGTDVGGGNRFSMISVLDDAYKVGMCNNTLLDGSI 357
Query: 359 NEKSLTLKEV----------FRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKAS--- 405
+ L E F TLGG++ L +D ++GNFE GKE D + ++P
Sbjct: 358 DPSRKDLAEAERNKLSPYRGFWSVTLGGAEGLYIDDKLGNFEPGKEADFVALDPNGGQLA 417
Query: 406 ----DSPIDLFYGDFFGDISEAVIQKFLYLGDDRNIEEVYVGGKQV 447
S I G D + +++ + +GDDR ++E +V GK++
Sbjct: 418 QPWHQSLIADGAGPRTVDEAASMLFAVMMVGDDRCVDETWVMGKRL 463
>4DYK-A nrPDB
Length = 451
Score = 137 bits (345), Expect = 9e-33, Method: Compositional matrix adjust.
Identities = 115/436 (26%), Positives = 198/436 (45%), Gaps = 44/436 (10%)
Query: 21 TWTCPME----VLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMP 76
TW P+E VLRDH LG+ D G+I + Q + EIREL P
Sbjct: 15 TWIVPVEPAGVVLRDHALGIRD-GQIALVAPREQAMR------HGATEIRELPGM-LLAP 66
Query: 77 GLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGT 136
GLV+ H H++ F G + DLPL+ WL + +PAE ++ + DF + + +K G
Sbjct: 67 GLVNAHGHSAMSLFRGLADDLPLMTWLQDHIWPAEGQWVSEDFIRDGTELAIAEQVKGGI 126
Query: 137 TTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESIKETERFVS 196
T F+ ++ + + D G RA V +D P +++ E+I++
Sbjct: 127 TC---FSDMYFYPQAICGVVHDS-GVRAQVAIPVLDF--PIPGARDSA-EAIRQGMALFD 179
Query: 197 EMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKNLYP 256
++ K++ R++ P + S+ + ++ + + D IQ H+ E EVE + +
Sbjct: 180 DL--KHHPRIRIAFGPHAPYTVSDDKLEQILVLTEELDASIQMHVHETAFEVE--QAMER 235
Query: 257 SYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAHCPNSNLSLSSGFLNVL 316
+ + + + LL + H + ++L + E +S+ HCP SNL L+SGF V
Sbjct: 236 NGERPLARLHRLGLLGPRFQAVHMTQVDNDDLAMLVETNSSVIHCPESNLKLASGFCPVE 295
Query: 317 EVLKHEVKIGLGTD-VAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATLG 375
++ + V + +GTD A +L R A +++ + +L R+ATL
Sbjct: 296 KLWQAGVNVAIGTDGAASNNDLDLLGETRTAALLAKAVYGQAT---ALDAHRALRMATLN 352
Query: 376 GSQALGLDGEIGNFEVGKEFDAILINPKASDSPIDLFYGDFFGDISEAV---IQKFLYLG 432
G++ALGL+ IG+ E GK DL D G + V + + +Y
Sbjct: 353 GARALGLERLIGSLEAGKA--------------ADLVAFDLSGLAQQPVYDPVSQLIYAS 398
Query: 433 DDRNIEEVYVGGKQVV 448
+ V+VGG+Q++
Sbjct: 399 GRDCVRHVWVGGRQLL 414
>4DZH-A nrPDB
Length = 472
Score = 135 bits (341), Expect = 2e-32, Method: Compositional matrix adjust.
Identities = 113/443 (25%), Positives = 191/443 (43%), Gaps = 55/443 (12%)
Query: 17 FVHSTWTCPME----VLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHE 72
+ + + P+E VL DH + VS+ + L A + + F P R +S +
Sbjct: 17 LIEAGYVVPIEPHAVVLEDHAVAVSNGVIVAVLPTADARVR------FAPA--RTVSRPD 68
Query: 73 F-FMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRT 131
MPGLV+ H H G + DLPL+ WL ++ +P E +F + T +
Sbjct: 69 AALMPGLVNAHTHNPMTLLRGVADDLPLMVWLQQHIWPVEAAVIGPEFVADGTTLAIAEM 128
Query: 132 LKNGTTTAC---YFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESI 188
L+ GTT +FA + A + + G RA VG V +D FP T +
Sbjct: 129 LRGGTTCVNENYFFADVQ-------AAVYKQHGFRALVGAVIID----FP-----TAWAS 172
Query: 189 KETERFVSEMLQKNYSRVKPIVTPRFSLSCSETL----MGELGNIAKTRDLHIQSHISEN 244
+ E F + R P+++ F+ T+ + +A D+ + H E
Sbjct: 173 SDDEYFARAGELHDQWRDDPLISTAFAPHAPYTVNDANFERVRMLADQLDMPVHLHTHET 232
Query: 245 RDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAHCPNS 304
EV Y + + D+ L+ ++ + H L+ E+++ ERG S+ HCP S
Sbjct: 233 AQEVADSVAQY--GQRPLARLDRLGLVNDRLIAVHMTQLTEAEIHLCAERGVSVVHCPES 290
Query: 305 NLSLSSGFLNVLEVLKHEVKIGLGTD-VAGGYSYSMLDAIRRAVMVSNILLINKVNEKSL 363
NL L+SGF + + V + +GTD A M R A +++ + + +L
Sbjct: 291 NLKLASGFCPACALQRASVNLAIGTDGCASNNDLDMFSENRTAAILAKAV---ANDATAL 347
Query: 364 TLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDS-PIDLFYGDFFGDISE 422
R ATLGG++ALG IG+ EVGK+ D + ++ A ++ P+
Sbjct: 348 DAATTLRAATLGGARALGFGDRIGSIEVGKQADLVCVDLSALETQPL------------H 395
Query: 423 AVIQKFLYLGDDRNIEEVYVGGK 445
V+ + +Y + +V++ GK
Sbjct: 396 HVLSQLIYAAGRHQVTDVWIAGK 418
>4F0R-A nrPDB
Length = 447
Score = 120 bits (301), Expect = 1e-27, Method: Compositional matrix adjust.
Identities = 102/378 (26%), Positives = 179/378 (47%), Gaps = 27/378 (7%)
Query: 27 EVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHAS 86
EVL +H + + D GKI + A+ L + E EL H MPGL++ H H++
Sbjct: 23 EVLENHAIAIRD-GKIAAIIPAADAAGLEAD------ERLELPDH-VLMPGLINLHGHSA 74
Query: 87 QYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTA--CYFAT 144
G + D L++WLT Y +P E + + DF + + ++ GTTT YF
Sbjct: 75 MSLLRGLADDKALMDWLTNYIWPTEGKHVHDDFVFDGSLLAMGEMIRGGTTTINDMYFYN 134
Query: 145 IHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFP-EYKETTEESIKETERFVSEMLQKNY 203
+ L + G R FVG ++ FP Y ++ I + S+ L ++
Sbjct: 135 AAVARAGLAS------GMRTFVGCSILE----FPTNYASNADDYIAKGMAERSQFLGEDL 184
Query: 204 SRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKNLYPSYKNYTS 263
+ + P + S+ ++ +A+ D+ I HI E DEV ++ + +
Sbjct: 185 --LTFTLAPHAPYTVSDDTFRKVVTLAEQEDMLIHCHIHETADEVN--NSVKEHGQRPLA 240
Query: 264 VYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAHCPNSNLSLSSGFLNVLEVLKHEV 323
+ LL+ + V AH +L+ E+ + G S AH P SN+ L+SG V +++ V
Sbjct: 241 RLQRLGLLSPRLVAAHMVHLNDAEVELAARHGLSTAHNPASNMKLASGISPVSKLMDAGV 300
Query: 324 KIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLD 383
+G+GTD G S + LD + + + + + ++ S+ R+ATL G++ALG+
Sbjct: 301 AVGIGTD--GAASNNKLDMLAETRLAALLAKVGTLDPTSVPAAAAIRMATLNGARALGIA 358
Query: 384 GEIGNFEVGKEFDAILIN 401
++G+ +VGK+ D I ++
Sbjct: 359 DKVGSVKVGKQADLIALD 376
>3LNP-A nrPDB
Length = 468
Score = 120 bits (300), Expect = 1e-27, Method: Compositional matrix adjust.
Identities = 117/450 (26%), Positives = 196/450 (43%), Gaps = 62/450 (13%)
Query: 18 VHSTWTCPME----------VLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPC-EIR 66
++S W P+E +L DH L + D G I+ +E S C P E
Sbjct: 27 INSHWIIPIENTTDHNLVSNILIDHCLLIKD-GIILAIEPQSS--------CQIPATETL 77
Query: 67 ELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTR 126
+L + MPG V+ H HA+ F G + DLPL+ WL ++ +PAE + + F ++
Sbjct: 78 DLGQ-QVLMPGWVNAHGHAAMSLFRGLADDLPLMTWLQEHVWPAEAQHVDEHFVKQGTEL 136
Query: 127 VVRRTLKNGTTTAC--YFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFP-EYKET 183
+ +++GTTT YF + + L A G RA +D FP Y +
Sbjct: 137 AIAEMIQSGTTTFADMYFYPQQSGEAALAA------GIRAVCFAPVLD----FPTNYAQN 186
Query: 184 TEESIKET----ERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQS 239
+E I++ +RF + + + V+ P + S+ + E+ ++ D+ +Q
Sbjct: 187 ADEYIRKAIECNDRFNNHPMNEQ-GLVQIGFGPHAPYTVSDEPLKEITMLSDQLDMPVQI 245
Query: 240 HISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIA 299
H+ E EV ++L K T L + H + ++ + + GASI
Sbjct: 246 HLHETDFEVS--ESLETFNKRPTQRLADIGFLNERVSCVHMTQVDDGDIKILQKTGASII 303
Query: 300 HCPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVN 359
HCP SNL L+SGF + ++ + + +GTD G S + LD + LL V+
Sbjct: 304 HCPESNLKLASGFCPIAKLSAANIPLAIGTD--GAASNNDLDMFSETKTAA--LLAKGVS 359
Query: 360 EKSLTLK--EVFRLATLGGSQALGLDGEIGNFEVGKEFD--AILINPKASDSPIDLFYGD 415
+ + + E +ATLGG++ALG+D G+ + GK D AI +N +S D
Sbjct: 360 QDASAIPAIEALTMATLGGARALGIDDITGSLKPGKAADIQAIDLNTLSSQPVFD----- 414
Query: 416 FFGDISEAVIQKFLYLGDDRNIEEVYVGGK 445
+ +Y + V+V G+
Sbjct: 415 --------PVSHMVYCTKSTQVSHVWVNGR 436
>3HPA-A nrPDB
Length = 479
Score = 83.2 bits (204), Expect = 2e-16, Method: Compositional matrix adjust.
Identities = 93/382 (24%), Positives = 171/382 (44%), Gaps = 35/382 (9%)
Query: 29 LRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQ- 87
LRD L + D+ +IV + +++ + A E + +L H +PGLV+TH H Q
Sbjct: 49 LRDAGLYIEDN-RIVAVGPSAELPETADE-------VLDLRGH-LVIPGLVNTHHHMYQS 99
Query: 88 -YSFAGSSIDLPLLEWLTK-YTFPAEHRFQNIDFAEEVYT-RVVRRTLKNGTTTACYFAT 144
++ + L WLT Y A + I EV T + L++G TT+
Sbjct: 100 LTRAVPAAQNAELFGWLTNLYKIWAHLTPEMI----EVSTLTAMAELLQSGCTTSSDHLY 155
Query: 145 IHTDSSLLLADI--TDKFGQRAFVGKVCMDL---NDTFP--EYKETTEESIKETERFVSE 197
I+ + S L I + G R + M + + P E + +++T+R +
Sbjct: 156 IYPNGSRLDDSIGAAQRIGMRFHASRGAMSVGQRDGGLPPDSVVEREPDILRDTQRLIET 215
Query: 198 ML-QKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKNLYP 256
+ Y+ ++ +V P S S LM + +A+ + + +H++EN +++ +
Sbjct: 216 YHDEGRYAMLRVVVAPCSPFSVSRDLMRDAAVLAREYGVSLHTHLAENVNDIAYSRE--- 272
Query: 257 SYKNYTSVYDKN-NLLTNKTVMAHGCYLSAEELNVFHERGASIAHCPNSNLSLSSGFLNV 315
+ + Y ++ + + AH L + +F G +AHCP SN+ L+SG V
Sbjct: 273 KFGMTPAEYAEDLGWVGHDVWHAHCVQLDDAGIGLFARTGTGVAHCPCSNMRLASGIAPV 332
Query: 316 LEVLKHEVKIGLGTD-VAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATL 374
++ V +GLG D A M+ +R+A+++ + ++T +E +ATL
Sbjct: 333 KKMRLAGVPVGLGVDGSASNDGAQMVAEVRQALLLQRV----GFGPDAMTAREALEIATL 388
Query: 375 GGSQALGLDGEIGNFEVGKEFD 396
GG++ L D +IG + G D
Sbjct: 389 GGAKVLNRD-DIGALKPGMAAD 409
>2PAJ-A nrPDB
Length = 492
Score = 77.8 bits (190), Expect = 8e-15, Method: Compositional matrix adjust.
Identities = 87/357 (24%), Positives = 146/357 (40%), Gaps = 49/357 (13%)
Query: 76 PGLVDTHIHASQYSFAG--SSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLK 133
P V+TH H Q G + +D L WL + RF+ + F E + R L
Sbjct: 70 PAWVNTHHHLFQSLLKGEPAGLDATLTPWLAATPY----RFRAL-FDERRFRLAARIGLI 124
Query: 134 NGTTTAC---------YFATIHTDSSLLLADITDKFGQRAFV-----GKVCMDLNDTFPE 179
+ C Y+ + DSS +L + +K G R FV L P
Sbjct: 125 ELARSGCATVADHNYVYYPGMPFDSSAILFEEAEKLGLR-FVLLRGGATQTRQLEADLPT 183
Query: 180 --YKETTEESIKETERFVSEMLQKNYSRVKPIV----TPRFSLSCSETLMGELGNIAKTR 233
ET + + + ER + + ++ +V T +S+S E M E +A+
Sbjct: 184 ALRPETLDAYVADIERLAARYHDASPRAMRRVVMAPTTVLYSISPRE--MRETAAVARRL 241
Query: 234 DLHIQSHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHE 293
L + SH+SE ++ ++Y K+ + +++ L + AH + A+E+ + +
Sbjct: 242 GLRMHSHLSETVGYQDSAYSMY--GKSPVAFCGEHDWLGSDVWYAHLVKVDADEIALLAQ 299
Query: 294 RGASIAHCPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMV---- 349
G +AHCP SN L SG V E+ V + +G D G S D I M
Sbjct: 300 TGTGVAHCPQSNGRLGSGICPVREMADAGVPVSIGVD--GAASNEAADMISEVHMTWLAQ 357
Query: 350 -SNILLINKVNEK---------SLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFD 396
+ + ++ + + + ++ EV T GG++ +GLD E+G VG D
Sbjct: 358 RARLGMLAQPAYRGGSFEGGAGAASIAEVIHWGTAGGARVMGLD-EVGKVAVGYAAD 413
>2PLM-A nrPDB
Length = 406
Score = 75.1 bits (183), Expect = 6e-14, Method: Compositional matrix adjust.
Identities = 79/330 (23%), Positives = 128/330 (38%), Gaps = 36/330 (10%)
Query: 75 MPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKN 134
MP L +TH HA G + DL EWL P E R + Y + ++
Sbjct: 48 MPALFNTHTHAPMTLLRGVAEDLSFEEWLFSKVLPIEDRLTE----KMAYYGTILAQMEM 103
Query: 135 GTTTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESIKETERF 194
F ++ + + D FG RA + + +D N E + E F
Sbjct: 104 ARHGIAGFVDMYFHEEWIAKAVRD-FGMRALLTRGLVDSNGDDGGRLEENLKLYNEWNGF 162
Query: 195 VSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDE---VEAV 251
R+ P CSE + + + AK+ + + H+ E E +E +
Sbjct: 163 --------EGRIFVGFGPHSPYLCSEEYLKRVFDTAKSLNAPVTIHLYETSKEEYDLEDI 214
Query: 252 KNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAHCPNSNLSLSSG 311
N+ L KT+ AH +L V + ++H P SNL L +G
Sbjct: 215 LNI--------------GLKEVKTIAAHCVHLPERYFGVLKDIPFFVSHNPASNLKLGNG 260
Query: 312 FLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRL 371
V +++H +K+ LGTD G S + L+ + S LL N ++L + ++
Sbjct: 261 IAPVQRMIEHGMKVTLGTD--GAASNNSLNLFFEMRLAS--LLQKAQNPRNLDVNTCLKM 316
Query: 372 ATLGGSQALGLDGEIGNFEVGKEFDAILIN 401
T G+QA+G G E G D ++I+
Sbjct: 317 VTYDGAQAMGFKS--GKIEEGWNADLVVID 344
>4V1Y-A nrPDB
Length = 494
Score = 74.3 bits (181), Expect = 1e-13, Method: Compositional matrix adjust.
Identities = 90/401 (22%), Positives = 162/401 (40%), Gaps = 49/401 (12%)
Query: 27 EVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHAS 86
VL D + V D G+IV L + E P + + + +PG ++ H H +
Sbjct: 39 RVLGDSWVHVQD-GRIVAL-------GVHAESVPPPADRVIDARGKVVLPGFINAHTHVN 90
Query: 87 QYSF-AGSSIDLPLLEWLTKYTFPAEH--RFQNIDFAEEVYTRVVRR----TLKNGTTTA 139
Q G S +WL +P + R +++ A +Y R T+ +A
Sbjct: 91 QILLRGGPSHGRQFYDWLFNVVYPGQKAMRPEDVAVAVRLYCAEAVRSGITTINENADSA 150
Query: 140 CYFATIHTDSSLLLADITDKFGQRAFVGKVCMD------------LNDTFPEYK--ETTE 185
Y I + + + G R ++ D L P+ + E
Sbjct: 151 IYPGNIEAAMA-----VYGEVGVRVVYARMFFDRMDGRIQGYVDALKARSPQVELCSIME 205
Query: 186 ESIKETERFVSEMLQKNY-----SRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSH 240
E+ +R + L Y R+ P + + + M A+ R + H
Sbjct: 206 ETAVAKDRITA--LSDQYHGTAGGRISVWPAPATTTAVTVEGMRWAQAFARDRAVMWTLH 263
Query: 241 ISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAH 300
++E+ D E + + P+ Y Y LL + +AH Y +++ + H +A
Sbjct: 264 MAES-DHDERIHGMSPA--EYMECY---GLLDERLQVAHCVYFDRKDVRLLHRHNVKVAS 317
Query: 301 CPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNE 360
SN L SG V E+++ + +G+GTD G S ++ I +++I +
Sbjct: 318 QVVSNAYLGSGVAPVPEMVERGMAVGIGTD--NGNSNDSVNMIGDMKFMAHIHRAVHRDA 375
Query: 361 KSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILIN 401
LT +++ +AT+ G+++LG+D EIG+ E GK D IL++
Sbjct: 376 DVLTPEKILEMATIDGARSLGMDHEIGSIETGKRADLILLD 416
>4LH8-A nrPDB
Length = 469
Score = 58.5 bits (140), Expect = 5e-09, Method: Compositional matrix adjust.
Identities = 79/346 (22%), Positives = 137/346 (39%), Gaps = 35/346 (10%)
Query: 75 MPGLVDTHIHASQYSFAGSSIDLPLLE------WLTKYTFPAEHRFQNIDFAEEVYTRVV 128
+PGL+++H Q+ + G+ +P LE WL + +++ F +V V
Sbjct: 69 LPGLINSH----QHLYEGAMRAIPQLERVTMASWLEGVLTRSAGWWRDGKFGPDVIREVA 124
Query: 129 R----RTLKNGTTTAC----YFATIHTDSSL-LLADITDKFGQRAFVGKVCMDLNDTFPE 179
R +L G TT +F DS + + G R + M L + E
Sbjct: 125 RAVLLESLLGGITTVADQHPFFPGATADSYIDATIEAATDLGIRFHAVRSSMTLGKS--E 182
Query: 180 YKETTEESIKETERFVSEMLQ--KNYSRVKPIVTPRFSLS-CS-----ETLMGELGNIAK 231
+ ++ +R V L Y +P R +L C L +A
Sbjct: 183 GGFCDDLFVEPVDRVVQHCLGLIDQYHEPEPFGMVRIALGPCGVPYDKPELFEAFAQMAA 242
Query: 232 TRDLHIQSHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVF 291
D+ + +H E D +LY +K+ +++ +AH EE+ F
Sbjct: 243 DYDVRLHTHFYEPLD-AGMSDHLY--GMTPWRFLEKHGWASDRVWLAHAVVPPREEIPEF 299
Query: 292 HERGASIAHCPNSNLSLSSGFLNVLEVLKHEVKIGLG-TDVAGGYSYSMLDAIRRAVMVS 350
+ G +IAH +L + G + E L + +G G T A ++L +R A +
Sbjct: 300 ADAGVAIAHLIAPDLRMGWGLAPIREYLDAGITVGFGTTGSASNDGGNLLGDLRLAALAH 359
Query: 351 NILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFD 396
N+ EK L+ +E+ R+AT G ++ LG ++G E G+ D
Sbjct: 360 RPADPNE-PEKWLSARELLRMATRGSAECLGRP-DLGVLEEGRAAD 403
>3V7P-A nrPDB
Length = 427
Score = 54.7 bits (130), Expect = 7e-08, Method: Compositional matrix adjust.
Identities = 66/235 (28%), Positives = 99/235 (42%), Gaps = 25/235 (10%)
Query: 192 ERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAV 251
ERF +N R K V S L +IAK + H E+R E E +
Sbjct: 159 ERFHQSKKHEN-ERFKAAVAIHSPYSVHYILAKRALDIAKKYGSLVSVHFMESRAEREWL 217
Query: 252 -------KNLYPSYKNYTS-VYDKNNLLTN----KTVMAHGCYLSAEELNVFHERGASIA 299
+ + N T V D + L T+ H + + EE+ A I
Sbjct: 218 DKGSGEFAKFFKEFLNQTRPVNDTKSFLELFKELHTLFVHMVWANEEEIQTIASYNAHII 277
Query: 300 HCPNSNLSLSSGFLNVLEVLKHEVKIGLGTD-VAGGYSYSMLDAIRRAVMVSNILLINKV 358
HCP SN L +G L+ LE +K + + TD ++ YS +M + ++ A L ++
Sbjct: 278 HCPISNRLLGNGVLD-LEKIK-SIPYAIATDGLSSNYSLNMYEELKAA------LFVHPN 329
Query: 359 NEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILIN-PKASDSPIDLF 412
E + KE+ AT G ALG +G G VGK+ D LI+ P+ + DL+
Sbjct: 330 KEATTFAKELIIRATKAGYDALGFEG--GEIAVGKDADMQLIDLPEGLTNVEDLY 382
>2IMR-A nrPDB
Length = 420
Score = 45.8 bits (107), Expect = 4e-05, Method: Compositional matrix adjust.
Identities = 69/327 (21%), Positives = 124/327 (37%), Gaps = 56/327 (17%)
Query: 81 THIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTAC 140
TH+ S Y F LP +W+ + H + + A+ + R L G
Sbjct: 100 THLDMSAYEFQA----LPYFQWIPEVVIRGRH-LRGVAAAQAGADTLTR--LGAGGVGDI 152
Query: 141 YFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPE-YKETTEESIKETERFVSEML 199
+A D+ L D++ G + ++ + FP+ E + ER+ L
Sbjct: 153 VWAPEVMDALLAREDLS---------GTLYFEVLNPFPDKADEVFAAARTHLERW--RRL 201
Query: 200 QKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKN------ 253
++ R+ ++P + S LM L + A L +Q H++E+ E+E +
Sbjct: 202 ERPGLRLG--LSPHTPFTVSHRLMRLLSDYAAGEGLPLQIHVAEHPTELEMFRTGGGPLW 259
Query: 254 ------LYP----------SYKNYTSV--YDKNNLLTNKTVMAHGCYLSAEELNVFHERG 295
LYP + T V D+ +L + + H ++ +++ G
Sbjct: 260 DNRMPALYPHTLAEVIGREPGPDLTPVRYLDELGVLAARPTLVHMVNVTPDDIARVARAG 319
Query: 296 ASIAHCPNSNLSLSSGFLNVLEVLKHEVKIGLGTD-VAGGYSYSMLDAIRRAVMVSNILL 354
++ CP SN L G + V++ LGTD VA G + + +R V + L
Sbjct: 320 CAVVTCPRSNHHLECGTFDWPAFAAAGVEVALGTDSVASGETLN----VREEVTFARQLY 375
Query: 355 INKVNEKSLTLKEVFRLATLGGSQALG 381
L + + R A GG + +G
Sbjct: 376 ------PGLDPRVLVRAAVKGGQRVVG 396
>4F0L-A nrPDB
Length = 458
Score = 42.7 bits (99), Expect = 3e-04, Method: Compositional matrix adjust.
Identities = 77/339 (22%), Positives = 124/339 (36%), Gaps = 47/339 (13%)
Query: 75 MPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNI-------------DFAE 121
+ G+ + H HA QY AG L + P+ F + + AE
Sbjct: 58 VAGMANLHSHAFQYGMAG----------LAERRGPSADSFWSWREIMYKFALTMTPEQAE 107
Query: 122 EVYTRVVRRTLKNGTTTACYFATIHTDSSLL----LADITDKFGQRAFVGKVCMDLNDTF 177
V R+ L+ G T F +H D L+++ D+ A + + L F
Sbjct: 108 AVALRLYVDMLEAGFTRVGEFHYLHHDCDGTPYANLSEMADRIAAAATTAGMGLTLLPVF 167
Query: 178 PEY--------KETTEESIKETERFVS--EMLQKNYSRVKPIVTPRFSLSCSETLMGELG 227
+ E I + ERF E +K + V S EL
Sbjct: 168 YAHSGFGGAAANEGQRRFINDPERFARLIEGCRKTLEGFEGAVLGVAPHSLRAVTPDELD 227
Query: 228 NIAKT-RDLHIQSHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAE 286
++ + D + H++E EVE + S K + +T + + H ++S E
Sbjct: 228 SVTQLLPDAPVHIHVAEQVKEVEDC--IAWSGKRPVEWLLDHQDVTARWCLIHATHMSDE 285
Query: 287 ELNVFHERGASIAHCPNSNLSLSSGFLNVLEVLKHEVKIGLGTD----VAGGYSYSMLDA 342
E + GA CP + +L G N E K G+G+D + G L+
Sbjct: 286 ETKHMAKAGAIAGLCPVTEANLGDGTFNATEFAAAGGKFGIGSDSNVLIGIGDELRQLEY 345
Query: 343 IRRAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALG 381
+R + +L NE S T + +F A LGG+ A+G
Sbjct: 346 SQRLYHRARNVL--AANEGS-TGRALFDGAVLGGNIAMG 381
>1YRR-A nrPDB
Length = 382
Score = 32.3 bits (72), Expect = 0.46, Method: Compositional matrix adjust.
Identities = 18/60 (30%), Positives = 30/60 (50%), Gaps = 11/60 (18%)
Query: 334 GYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGK 393
G S +M++ +R N V + L EV R+ATL ++A+G++ +G GK
Sbjct: 308 GSSLTMIEGVR-----------NLVEHCGIALDEVLRMATLYPARAIGVEKRLGTLAAGK 356
>3IV8-A nrPDB
Length = 381
Score = 32.0 bits (71), Expect = 0.56, Method: Compositional matrix adjust.
Identities = 17/60 (28%), Positives = 32/60 (53%), Gaps = 11/60 (18%)
Query: 333 GGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVG 392
GG + +M++A++ N V + L E R+ATL ++A+G+D ++G + G
Sbjct: 307 GGSALTMIEAVQ-----------NTVEHVGIALDEALRMATLYPAKAIGVDEKLGRIKKG 355
>3MKV-A nrPDB
Length = 426
Score = 30.8 bits (68), Expect = 1.2, Method: Compositional matrix adjust.
Identities = 46/230 (20%), Positives = 89/230 (38%), Gaps = 31/230 (13%)
Query: 186 ESIKETERFVSEMLQKNYSRVKPIVT--------PRFSLSCSETLMGELGNIAKTRDLHI 237
+ + E R V E LQ ++K + + P SE + + A+ R ++
Sbjct: 172 DGVDEVRRAVREELQMGADQIKIMASGGVASPTDPVGVFGYSEDEIRAIVAEAQGRGTYV 231
Query: 238 QSHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEEL--NVFHERG 295
+H AV+ + ++ + D+ T + V HG Y+ + + G
Sbjct: 232 LAHAYTPAAIARAVRCGVRTIEHGNLIDDE----TARLVAEHGAYVVPTLVTYDALASEG 287
Query: 296 ASIAHCPNSNLSLS---SGFLNVLEVLKHE-VKIGLGTDVAGGYSYSMLDAIRRAVMVSN 351
P S ++ L+ +E++K VK+G GTD+ G D R
Sbjct: 288 EKYGLPPESIAKIADVHGAGLHSIEIMKRAGVKMGFGTDLLGEAQRLQSDEFR------- 340
Query: 352 ILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILIN 401
+ + L+ EV AT+ ++ LG+ ++G G D ++++
Sbjct: 341 ------ILAEVLSPAEVIASATIVSAEVLGMQDKLGRIVPGAHADVLVVD 384
>2P9B-A nrPDB
Length = 458
Score = 30.4 bits (67), Expect = 1.6, Method: Compositional matrix adjust.
Identities = 15/40 (37%), Positives = 21/40 (52%)
Query: 367 EVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASD 406
E AT + LG+D E G+ EVGK D +++N D
Sbjct: 373 EALHAATAVNASILGVDAETGSLEVGKSADLLVLNANPLD 412
>3IEQ-A nrPDB
Length = 183
Score = 30.0 bits (66), Expect = 2.3, Method: Compositional matrix adjust.
Identities = 20/69 (28%), Positives = 32/69 (46%), Gaps = 2/69 (2%)
Query: 122 EVYTRVVRRTLKNGTTTACYFATI--HTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPE 179
+V+ V R L G T Y + H+D+ +LL ITD A +G + +DT P
Sbjct: 31 DVHQLVPGRPLIIGGVTIPYERGLLGHSDADVLLHAITDALFGAAALGDIGRHFSDTDPR 90
Query: 180 YKETTEESI 188
+K ++
Sbjct: 91 FKGADSRAL 99
>5XJN-A nrPDB
Length = 455
Score = 29.6 bits (65), Expect = 2.7, Method: Compositional matrix adjust.
Identities = 19/54 (35%), Positives = 24/54 (44%), Gaps = 4/54 (7%)
Query: 137 TTACYFATIHTDSSLLLADITDK----FGQRAFVGKVCMDLNDTFPEYKETTEE 186
T A F H DS L D DK G + G D+++ FP YKE +E
Sbjct: 21 TAAAKFERQHMDSPDLGTDDDDKAMADIGSTSHHGYQPFDMHNPFPAYKELRQE 74
>2XP1-A nrPDB
Length = 178
Score = 28.1 bits (61), Expect = 7.7, Method: Compositional matrix adjust.
Identities = 34/120 (28%), Positives = 49/120 (40%), Gaps = 16/120 (13%)
Query: 95 IDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTACYFATIHTDSSLLLA 154
+ + + E YT +H F++ID VY R + R LK+ A YF + LL +
Sbjct: 59 VHMKIEEHSEHYTCSNKH-FEDIDEVISVYVRPILRNLKSIKAHAKYFNSPEDAEKLLSS 117
Query: 155 DITDK-----FGQRAFVGKVCMDLNDTFPEYKETTEESIKETERFVSEMLQKNYSRVKPI 209
K + R + GK+ N+ SI E VS+ML N S K I
Sbjct: 118 FDGSKVVYAFYFSRKYPGKLTFAYNNG----------SILEEYIGVSDMLTYNNSTFKDI 167
>2XDQ-A nrPDB
Length = 460
Score = 27.7 bits (60), Expect = 9.6, Method: Compositional matrix adjust.
Identities = 22/71 (30%), Positives = 31/71 (43%), Gaps = 6/71 (8%)
Query: 61 KPCEIRELSHHEFFMPGLVDTHI-HASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDF 119
KP +L + P LV T + HA+ G S +W ++TF H F N
Sbjct: 380 KPDNYNQLQRIKALQPDLVITGMAHANPLEARGIST-----KWSVEFTFAQIHGFGNARD 434
Query: 120 AEEVYTRVVRR 130
E+ TR +RR
Sbjct: 435 ILELVTRPLRR 445
>4WHB-E nrPDB
Length = 461
Score = 27.7 bits (60), Expect = 9.8, Method: Compositional matrix adjust.
Identities = 15/47 (31%), Positives = 25/47 (53%)
Query: 360 EKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASD 406
EK ++ E AT+ ++A G +IG+ E GK D +L++ D
Sbjct: 381 EKGMSPLEAISAATINVARAYGKADQIGSVETGKLADFVLLDQDPVD 427
Searching..................................................done
Results from round 2
Score E
Sequences producing significant alignments: (bits) Value
Sequences used in model and found again:
3E0L-A nrPDB 609 e-175
2I9U-A nrPDB 395 e-110
3LNP-A nrPDB 384 e-107
4DYK-A nrPDB 379 e-105
2OOD-A nrPDB 363 e-101
4DZH-A nrPDB 361 e-100
4F0R-A nrPDB 354 5e-98
3HPA-A nrPDB 302 2e-82
4V1Y-A nrPDB 291 5e-79
2PLM-A nrPDB 283 1e-76
2PAJ-A nrPDB 261 5e-70
4LH8-A nrPDB 260 1e-69
4F0L-A nrPDB 229 2e-60
3V7P-A nrPDB 205 3e-53
2IMR-A nrPDB 194 6e-50
Sequences not found previously or not previously below threshold:
3MDW-A nrPDB 162 2e-40
2BB0-A nrPDB 84 2e-16
2P9B-A nrPDB 80 2e-15
3MKV-A nrPDB 80 3e-15
4CQD-A nrPDB 78 1e-14
2PUZ-A nrPDB 77 1e-14
2OOF-A nrPDB 76 3e-14
4WGX-A nrPDB 64 1e-10
1R9X-A nrPDB 63 3e-10
3N2C-A nrPDB 61 1e-09
3MTW-A nrPDB 60 2e-09
4WHB-E nrPDB 59 3e-09
4C65-A nrPDB 57 2e-08
2QS8-A nrPDB 54 1e-07
2OGJ-A nrPDB 49 4e-06
3OOQ-A nrPDB 49 5e-06
1XRT-A nrPDB 48 7e-06
1YRR-A nrPDB 44 1e-04
1NFG-A nrPDB 44 1e-04
6NBO-A nrPDB 43 2e-04
6AJD-A nrPDB 43 2e-04
3EWD-A nrPDB 43 2e-04
6II7-A nrPDB 42 4e-04
2AMX-A nrPDB 41 9e-04
2VUN-A nrPDB 41 0.001
3E74-A nrPDB 41 0.001
1YNY-A nrPDB 39 0.005
3IV8-A nrPDB 39 0.006
1GKQ-A nrPDB 38 0.012
3T8L-A nrPDB 36 0.025
4CEX-C nrPDB 36 0.029
2VHL-A nrPDB 36 0.030
5NKS-A nrPDB 36 0.036
3IGH-X nrPDB 36 0.040
4Z42-C nrPDB 35 0.068
3MPG-A nrPDB 34 0.097
1RK6-A nrPDB 34 0.12
5XGX-A nrPDB 34 0.14
4LCQ-A nrPDB 34 0.14
2ICS-A nrPDB 34 0.17
1E9Y-B nrPDB 33 0.25
4H9M-A nrPDB 33 0.28
3SFW-A nrPDB 33 0.33
3S9V-A nrPDB 33 0.40
4G7E-B nrPDB 33 0.41
3TAC-A nrPDB 33 0.44
4OTK-A nrPDB 32 0.58
1FWC-C nrPDB 32 0.70
3QGK-C nrPDB 32 0.75
4TQT-A nrPDB 31 0.92
1K1D-A nrPDB 31 0.93
6HAW-A nrPDB 31 1.3
3DC8-A nrPDB 31 1.3
6N91-A nrPDB 31 1.5
3R64-A nrPDB 30 1.8
1GKR-A nrPDB 30 1.9
4YHJ-A nrPDB 30 2.3
3CKY-A nrPDB 29 3.0
1C8N-A nrPDB 29 3.1
2VR2-A nrPDB 29 3.2
1SQH-A nrPDB 29 3.3
5NSQ-A nrPDB 29 3.9
3GIQ-A nrPDB 29 4.0
6D8G-A nrPDB 29 4.2
4OJZ-A nrPDB 29 5.2
1BEV-3 nrPDB 29 6.0
5YZA-A nrPDB 28 7.0
4NML-A nrPDB 28 7.8
>3E0L-A nrPDB
Length = 455
Score = 609 bits (1571), Expect = e-175, Method: Composition-based stats.
Identities = 448/454 (98%), Positives = 448/454 (98%), Gaps = 2/454 (0%)
Query: 1 MCAAQMPPLAHIFRGTFVHSTWTCPMEVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCF 60
MCAAQMPPLAHIFRGTFVHSTWTCPMEVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCF
Sbjct: 4 MCAAQMPPLAHIFRGTFVHSTWTCPMEVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCF 63
Query: 61 KPCEIRELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFA 120
KPCEIRELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFA
Sbjct: 64 KPCEIRELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFA 123
Query: 121 EEVYTRVVRRTLKNGTTTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEY 180
EEVYTRVVRRTLKNGTTTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEY
Sbjct: 124 EEVYTRVVRRTLKNGTTTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEY 183
Query: 181 KETTEESIKETERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSH 240
KETTEESIKETERFVSEMLQKNYSRVKPIVTP SETLMGELGNIAKTRDLHIQSH
Sbjct: 184 KETTEESIKETERFVSEMLQKNYSRVKPIVTP--GNGVSETLMGELGNIAKTRDLHIQSH 241
Query: 241 ISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAH 300
ISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAH
Sbjct: 242 ISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAH 301
Query: 301 CPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNE 360
CPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNE
Sbjct: 302 CPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNE 361
Query: 361 KSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDSPIDLFYGDFFGDI 420
KSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDSPIDLFYGDFFGDI
Sbjct: 362 KSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDSPIDLFYGDFFGDI 421
Query: 421 SEAVIQKFLYLGDDRNIEEVYVGGKQVVPFSSSV 454
SEAVIQKFLYLGDDRNIEEVYVGGKQVVPFSSSV
Sbjct: 422 SEAVIQKFLYLGDDRNIEEVYVGGKQVVPFSSSV 455
>2I9U-A nrPDB
Length = 439
Score = 395 bits (1014), Expect = e-110, Method: Composition-based stats.
Identities = 162/439 (36%), Positives = 244/439 (55%), Gaps = 27/439 (6%)
Query: 12 IFRGTFVHSTWTCPMEVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHH 71
IF+G + + + +++D + V D GKI AS L ++ P +
Sbjct: 12 IFKGNLIFTKTSDKFTIMKDSYIVVID-GKI-----ASVSSNLPDKYKGNPI---IDFRN 62
Query: 72 EFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRT 131
+PG+ D H HASQY G +D LL WL YTFP E +F N+D+A++ Y R+++
Sbjct: 63 NIIIPGMNDLHAHASQYKNLGIGMDKELLPWLNNYTFPEEAKFLNVDYAKKTYGRLIKDL 122
Query: 132 LKNGTTTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEY-KETTEESIKE 190
+KNGTT FAT+H DS++ L ++ K G A+VGKV MD N P+Y E S+ +
Sbjct: 123 IKNGTTRVALFATLHKDSTIELFNMLIKSGIGAYVGKVNMDYN--CPDYLTENYITSLND 180
Query: 191 TERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEA 250
TE + + K+ + VKPI+TPRF SCS LM LG ++ L +QSH+SEN DE+
Sbjct: 181 TEEIILKYKDKS-NIVKPIITPRFVPSCSNELMDGLGKLSYKYRLPVQSHLSENLDEIAV 239
Query: 251 VKNLYPSYKNYTSVYDKNNLLTNK-TVMAHGCYLSAEELNVFHERGASIAHCPNSNLSLS 309
VK+L+ Y VYDK L N T+MAH + S EE+N+ +I HCP SN +L
Sbjct: 240 VKSLHKKSNFYGEVYDKFGLFGNTPTLMAHCIHSSKEEINLIKRNNVTIVHCPTSNFNLG 299
Query: 310 SGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNEKS-LTLKEV 368
SG + V + L + + LG+D++ G++ S+ I A+ S I + L+ E
Sbjct: 300 SGMMPVRKYLNLGINVVLGSDISAGHTCSLFKVIAYAIQNSKIKWQESGKKDMFLSTSEA 359
Query: 369 FRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDSPIDLFYGDFFGDISEAVIQKF 428
F +AT G G ++G+FE G +FDA++IN +L+ D+ D++E +++F
Sbjct: 360 FYMATKKGGSFFG---KVGSFEEGYDFDALVINDS------NLYPEDY--DLTER-LERF 407
Query: 429 LYLGDDRNIEEVYVGGKQV 447
+YLGDDRNI + YV G ++
Sbjct: 408 IYLGDDRNIMKRYVCGNEI 426
>3LNP-A nrPDB
Length = 468
Score = 384 bits (986), Expect = e-107, Method: Composition-based stats.
Identities = 116/463 (25%), Positives = 196/463 (42%), Gaps = 58/463 (12%)
Query: 5 QMPPLAHIFRGTFVHSTWTCPME----------VLRDHLLGVSDSGKIVFLEEASQQEKL 54
Q P AH ++S W P+E +L DH L + D G I+ +E S
Sbjct: 16 QSQPKAH--ADLRINSHWIIPIENTTDHNLVSNILIDHCLLIKD-GIILAIEPQS----- 67
Query: 55 AKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRF 114
C P + MPG V+ H HA+ F G + DLPL+ WL ++ +PAE +
Sbjct: 68 ---SCQIPATETLDLGQQVLMPGWVNAHGHAAMSLFRGLADDLPLMTWLQEHVWPAEAQH 124
Query: 115 QNIDFAEEVYTRVVRRTLKNGTTTAC--YFATIHTDSSLLLADITDKFGQRAFVGKVCMD 172
+ F ++ + +++GTTT YF + + L A G RA +D
Sbjct: 125 VDEHFVKQGTELAIAEMIQSGTTTFADMYFYPQQSGEAALAA------GIRAVCFAPVLD 178
Query: 173 LNDTFP-EYKETTEESIKET----ERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELG 227
FP Y + +E I++ +RF + + + V+ P + S+ + E+
Sbjct: 179 ----FPTNYAQNADEYIRKAIECNDRFNNHPMNEQ-GLVQIGFGPHAPYTVSDEPLKEIT 233
Query: 228 NIAKTRDLHIQSHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEE 287
++ D+ +Q H+ E EV ++L K T L + H + +
Sbjct: 234 MLSDQLDMPVQIHLHETDFEVS--ESLETFNKRPTQRLADIGFLNERVSCVHMTQVDDGD 291
Query: 288 LNVFHERGASIAHCPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAV 347
+ + + GASI HCP SNL L+SGF + ++ + + +GTD G S + LD
Sbjct: 292 IKILQKTGASIIHCPESNLKLASGFCPIAKLSAANIPLAIGTD--GAASNNDLDMFSETK 349
Query: 348 MVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFD--AILINPKAS 405
+ + + ++ E +ATLGG++ALG+D G+ + GK D AI +N +S
Sbjct: 350 TAALLAKGVSQDASAIPAIEALTMATLGGARALGIDDITGSLKPGKAADIQAIDLNTLSS 409
Query: 406 DSPIDLFYGDFFGDISEAVIQKFLYLGDDRNIEEVYVGGKQVV 448
D + +Y + V+V G+ ++
Sbjct: 410 QPVFD-------------PVSHMVYCTKSTQVSHVWVNGRCLL 439
>4DYK-A nrPDB
Length = 451
Score = 379 bits (974), Expect = e-105, Method: Composition-based stats.
Identities = 112/439 (25%), Positives = 197/439 (44%), Gaps = 42/439 (9%)
Query: 17 FVHSTWTCPME----VLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHE 72
+ TW P+E VLRDH LG+ D G+I + Q + EIREL
Sbjct: 11 LLLPTWIVPVEPAGVVLRDHALGIRD-GQIALVAPREQAMR------HGATEIRELPGM- 62
Query: 73 FFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTL 132
PGLV+ H H++ F G + DLPL+ WL + +PAE ++ + DF + + +
Sbjct: 63 LLAPGLVNAHGHSAMSLFRGLADDLPLMTWLQDHIWPAEGQWVSEDFIRDGTELAIAEQV 122
Query: 133 KNGTTTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESIKETE 192
K G T F+ ++ + + D G RA V +D P +++ E+I++
Sbjct: 123 KGGITC---FSDMYFYPQAICGVVHDS-GVRAQVAIPVLDF--PIPGARDSA-EAIRQGM 175
Query: 193 RFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVK 252
++ K++ R++ P + S+ + ++ + + D IQ H+ E EVE +
Sbjct: 176 ALFDDL--KHHPRIRIAFGPHAPYTVSDDKLEQILVLTEELDASIQMHVHETAFEVE--Q 231
Query: 253 NLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAHCPNSNLSLSSGF 312
+ + + + + LL + H + ++L + E +S+ HCP SNL L+SGF
Sbjct: 232 AMERNGERPLARLHRLGLLGPRFQAVHMTQVDNDDLAMLVETNSSVIHCPESNLKLASGF 291
Query: 313 LNVLEVLKHEVKIGLGTD-VAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRL 371
V ++ + V + +GTD A +L R A +++ + +L R+
Sbjct: 292 CPVEKLWQAGVNVAIGTDGAASNNDLDLLGETRTAALLAKAVYGQA---TALDAHRALRM 348
Query: 372 ATLGGSQALGLDGEIGNFEVGKEFDAILINPKAS--DSPIDLFYGDFFGDISEAVIQKFL 429
ATL G++ALGL+ IG+ E GK D + + D + + +
Sbjct: 349 ATLNGARALGLERLIGSLEAGKAADLVAFDLSGLAQQPVYD-------------PVSQLI 395
Query: 430 YLGDDRNIEEVYVGGKQVV 448
Y + V+VGG+Q++
Sbjct: 396 YASGRDCVRHVWVGGRQLL 414
>2OOD-A nrPDB
Length = 475
Score = 363 bits (932), Expect = e-101, Method: Composition-based stats.
Identities = 126/441 (28%), Positives = 199/441 (45%), Gaps = 34/441 (7%)
Query: 30 RDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQYS 89
+D L+ V+D G I + P +PG +D HIH Q
Sbjct: 34 QDGLMVVTD-GVIKAFGPYEKIAAAH------PGVEITHIKDRIIVPGFIDGHIHLPQTR 86
Query: 90 FAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTACYFATIHTDS 149
G+ + LL WL K +P E ++++ ++A E R + L GTTT F + +
Sbjct: 87 VLGAYGE-QLLPWLQKSIYPEEIKYKDRNYAREGVKRFLDALLAAGTTTCQAFTSSSPVA 145
Query: 150 SLLLADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESIKETERFVSEMLQKNYSRVKPI 209
+ L + + R G +D N E+ +T E ++++R +++ K R
Sbjct: 146 TEELFEEASRRNMRVIAGLTGIDRNAP-AEFIDTPENFYRDSKRLIAQYHDK--GRNLYA 202
Query: 210 VTPRFSLSCSETLMGELGNIAKTR-DLHIQSHISENRDEVEAVKNLYPSYKNYTSVYDKN 268
+TPRF+ S L+ + D + +HISEN E V +P ++Y VY+K
Sbjct: 203 ITPRFAFGASPELLKACQRLKHEHPDCWVNTHISENPAECSGVLVEHPDCQDYLGVYEKF 262
Query: 269 NLLTNKTVMAHGCYLSAEELNVFHERGASIAHCPNSNLSLSSGFLNVLEVLK--HEVKIG 326
+L+ K HG YLS E ++GA++ CP SNL L SG + H VK+
Sbjct: 263 DLVGPKFSGGHGVYLSNNEFRRMSKKGAAVVFCPCSNLFLGSGLFRLGRATDPEHRVKMS 322
Query: 327 LGTDVAGGYSYSM---LDAIRRAVMVSNILLINKVNEKSLTLKEV----------FRLAT 373
GTDV GG +SM LD + M +N LL ++ L E F T
Sbjct: 323 FGTDVGGGNRFSMISVLDDAYKVGMCNNTLLDGSIDPSRKDLAEAERNKLSPYRGFWSVT 382
Query: 374 LGGSQALGLDGEIGNFEVGKEFDAILINPKAS-------DSPIDLFYGDFFGDISEAVIQ 426
LGG++ L +D ++GNFE GKE D + ++P S I G D + +++
Sbjct: 383 LGGAEGLYIDDKLGNFEPGKEADFVALDPNGGQLAQPWHQSLIADGAGPRTVDEAASMLF 442
Query: 427 KFLYLGDDRNIEEVYVGGKQV 447
+ +GDDR ++E +V GK++
Sbjct: 443 AVMMVGDDRCVDETWVMGKRL 463
>4DZH-A nrPDB
Length = 472
Score = 361 bits (926), Expect = e-100, Method: Composition-based stats.
Identities = 109/441 (24%), Positives = 182/441 (41%), Gaps = 51/441 (11%)
Query: 17 FVHSTWTCPME----VLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHE 72
+ + + P+E VL DH + VS+ + L A + + F P
Sbjct: 17 LIEAGYVVPIEPHAVVLEDHAVAVSNGVIVAVLPTADARVR------FAPARTVSRP-DA 69
Query: 73 FFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTL 132
MPGLV+ H H G + DLPL+ WL ++ +P E +F + T + L
Sbjct: 70 ALMPGLVNAHTHNPMTLLRGVADDLPLMVWLQQHIWPVEAAVIGPEFVADGTTLAIAEML 129
Query: 133 KNGTTTAC---YFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESIK 189
+ GTT +FA + A + + G RA VG V +D FP T +
Sbjct: 130 RGGTTCVNENYFFADVQ-------AAVYKQHGFRALVGAVIID----FP-----TAWASS 173
Query: 190 ETERFVSEMLQKNYSRVKP----IVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENR 245
+ E F + R P P + ++ + +A D+ + H E
Sbjct: 174 DDEYFARAGELHDQWRDDPLISTAFAPHAPYTVNDANFERVRMLADQLDMPVHLHTHETA 233
Query: 246 DEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAHCPNSN 305
EV Y + + D+ L+ ++ + H L+ E+++ ERG S+ HCP SN
Sbjct: 234 QEVADSVAQY--GQRPLARLDRLGLVNDRLIAVHMTQLTEAEIHLCAERGVSVVHCPESN 291
Query: 306 LSLSSGFLNVLEVLKHEVKIGLGTD-VAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLT 364
L L+SGF + + V + +GTD A M R A +++ + + +L
Sbjct: 292 LKLASGFCPACALQRASVNLAIGTDGCASNNDLDMFSENRTAAILAKAV---ANDATALD 348
Query: 365 LKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDSPIDLFYGDFFGDISEAV 424
R ATLGG++ALG IG+ EVGK+ D + ++ A ++ V
Sbjct: 349 AATTLRAATLGGARALGFGDRIGSIEVGKQADLVCVDLSALET-----------QPLHHV 397
Query: 425 IQKFLYLGDDRNIEEVYVGGK 445
+ + +Y + +V++ GK
Sbjct: 398 LSQLIYAAGRHQVTDVWIAGK 418
>4F0R-A nrPDB
Length = 447
Score = 354 bits (907), Expect = 5e-98, Method: Composition-based stats.
Identities = 106/438 (24%), Positives = 194/438 (44%), Gaps = 40/438 (9%)
Query: 17 FVHSTWTCPME----VLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHE 72
+ + W +E VL +H + + D GKI + A+ L + E EL H
Sbjct: 9 IISARWIITVETDGEVLENHAIAIRD-GKIAAIIPAADAAGLEAD------ERLELPDH- 60
Query: 73 FFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTL 132
MPGL++ H H++ G + D L++WLT Y +P E + + DF + + +
Sbjct: 61 VLMPGLINLHGHSAMSLLRGLADDKALMDWLTNYIWPTEGKHVHDDFVFDGSLLAMGEMI 120
Query: 133 KNGTTTA--CYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESIKE 190
+ GTTT YF + L + G R FVG ++ Y ++ I +
Sbjct: 121 RGGTTTINDMYFYNAAVARAGLAS------GMRTFVGCSILEFPT---NYASNADDYIAK 171
Query: 191 TERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEA 250
S+ L ++ + + P + S+ ++ +A+ D+ I HI E DEV
Sbjct: 172 GMAERSQFLGEDL--LTFTLAPHAPYTVSDDTFRKVVTLAEQEDMLIHCHIHETADEVN- 228
Query: 251 VKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAHCPNSNLSLSS 310
++ + + + LL+ + V AH +L+ E+ + G S AH P SN+ L+S
Sbjct: 229 -NSVKEHGQRPLARLQRLGLLSPRLVAAHMVHLNDAEVELAARHGLSTAHNPASNMKLAS 287
Query: 311 GFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFR 370
G V +++ V +G+GTD G S + LD + + + + + ++ S+ R
Sbjct: 288 GISPVSKLMDAGVAVGIGTD--GAASNNKLDMLAETRLAALLAKVGTLDPTSVPAAAAIR 345
Query: 371 LATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDSPIDLFYGDFFGDISEAVIQKFLY 430
+ATL G++ALG+ ++G+ +VGK+ D I ++ ++ I +Y
Sbjct: 346 MATLNGARALGIADKVGSVKVGKQADLIALDLAQLETAPAF-----------DPISHVVY 394
Query: 431 LGDDRNIEEVYVGGKQVV 448
+ V+V G+ ++
Sbjct: 395 AAGREQVSHVWVKGRALM 412
>3HPA-A nrPDB
Length = 479
Score = 302 bits (774), Expect = 2e-82, Method: Composition-based stats.
Identities = 94/432 (21%), Positives = 174/432 (40%), Gaps = 42/432 (9%)
Query: 29 LRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQY 88
LRD L + D+ +IV + +++ + A E+ +L H +PGLV+TH H Q
Sbjct: 49 LRDAGLYIEDN-RIVAVGPSAELPETAD-------EVLDLRGH-LVIPGLVNTHHHMYQS 99
Query: 89 SFA--GSSIDLPLLEWLTK-YTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTACYFATI 145
++ + L WLT Y A + I+ + + L++G TT+ I
Sbjct: 100 LTRAVPAAQNAELFGWLTNLYKIWAHLTPEMIEVS---TLTAMAELLQSGCTTSSDHLYI 156
Query: 146 HTDSSLLLADI--TDKFGQRAFVGKVCMDLNDTFPE-----YKETTEESIKETERFVSEM 198
+ + S L I + G R + M + E + +++T+R +
Sbjct: 157 YPNGSRLDDSIGAAQRIGMRFHASRGAMSVGQRDGGLPPDSVVEREPDILRDTQRLIETY 216
Query: 199 LQK-NYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKNLYPS 257
+ Y+ ++ +V P S S LM + +A+ + + +H++EN +++ +
Sbjct: 217 HDEGRYAMLRVVVAPCSPFSVSRDLMRDAAVLAREYGVSLHTHLAENVNDIAYSR--EKF 274
Query: 258 YKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAHCPNSNLSLSSGFLNVLE 317
+ + + AH L + +F G +AHCP SN+ L+SG V +
Sbjct: 275 GMTPAEYAEDLGWVGHDVWHAHCVQLDDAGIGLFARTGTGVAHCPCSNMRLASGIAPVKK 334
Query: 318 VLKHEVKIGLGTD-VAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATLGG 376
+ V +GLG D A M+ +R+A+++ + ++T +E +ATLGG
Sbjct: 335 MRLAGVPVGLGVDGSASNDGAQMVAEVRQALLLQRV----GFGPDAMTAREALEIATLGG 390
Query: 377 SQALGLDGEIGNFEVGKEFDAILINPKASDSPIDLFYGDFFGDISEAVIQKFLYLGDDRN 436
++ L D IG + G D + + F + ++
Sbjct: 391 AKVLNRDD-IGALKPGMAADFAAFDLR----------QPLFAGALHDPVAALVFCAPS-Q 438
Query: 437 IEEVYVGGKQVV 448
V GK VV
Sbjct: 439 TAYTVVNGKVVV 450
>4V1Y-A nrPDB
Length = 494
Score = 291 bits (744), Expect = 5e-79, Method: Composition-based stats.
Identities = 88/403 (21%), Positives = 165/403 (40%), Gaps = 41/403 (10%)
Query: 27 EVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHAS 86
VL D + V D G+IV L + E P + + + +PG ++ H H +
Sbjct: 39 RVLGDSWVHVQD-GRIVAL-------GVHAESVPPPADRVIDARGKVVLPGFINAHTHVN 90
Query: 87 QYSFAG-SSIDLPLLEWLTKYTFPAEH--RFQNIDFAEEVYTRVVRRTLKNGTTTACYFA 143
Q G S +WL +P + R +++ A +Y +++G TT A
Sbjct: 91 QILLRGGPSHGRQFYDWLFNVVYPGQKAMRPEDVAVAVRLYC---AEAVRSGITTINENA 147
Query: 144 T--IHTDSSLLLADITDKFGQRAFVGKVCMD------------LNDTFPEYK--ETTEES 187
I+ + + + G R ++ D L P+ + EE+
Sbjct: 148 DSAIYPGNIEAAMAVYGEVGVRVVYARMFFDRMDGRIQGYVDALKARSPQVELCSIMEET 207
Query: 188 IKETERFVS---EMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISEN 244
+R + + R+ P + + + M A+ R + H++E+
Sbjct: 208 AVAKDRITALSDQYHGTAGGRISVWPAPATTTAVTVEGMRWAQAFARDRAVMWTLHMAES 267
Query: 245 RDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAHCPNS 304
D E + + P+ Y Y LL + +AH Y +++ + H +A S
Sbjct: 268 -DHDERIHGMSPA--EYMECY---GLLDERLQVAHCVYFDRKDVRLLHRHNVKVASQVVS 321
Query: 305 NLSLSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLT 364
N L SG V E+++ + +G+GTD G S ++ I +++I + LT
Sbjct: 322 NAYLGSGVAPVPEMVERGMAVGIGTD--NGNSNDSVNMIGDMKFMAHIHRAVHRDADVLT 379
Query: 365 LKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDS 407
+++ +AT+ G+++LG+D EIG+ E GK D IL++ + +
Sbjct: 380 PEKILEMATIDGARSLGMDHEIGSIETGKRADLILLDLRHPQT 422
>2PLM-A nrPDB
Length = 406
Score = 283 bits (723), Expect = 1e-76, Method: Composition-based stats.
Identities = 85/408 (20%), Positives = 149/408 (36%), Gaps = 36/408 (8%)
Query: 33 LLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQYSFAG 92
L + D F + K ++ + MP L +TH HA G
Sbjct: 6 CLILKDFSSEPFWGAVEIENGTIKRVLQGEVKVDLDLSGKLVMPALFNTHTHAPMTLLRG 65
Query: 93 SSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTACYFATIHTDSSLL 152
+ DL EWL P E R + Y + ++ F ++ +
Sbjct: 66 VAEDLSFEEWLFSKVLPIEDRLTE----KMAYYGTILAQMEMARHGIAGFVDMYFHEEWI 121
Query: 153 LADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESIKETERFVSEMLQKNYSRVKPIVTP 212
+ D FG RA + + +D N E + E F R+ P
Sbjct: 122 AKAVRD-FGMRALLTRGLVDSNGDDGGRLEENLKLYNEWNGF--------EGRIFVGFGP 172
Query: 213 RFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLT 272
CSE + + + AK+ + + H+ E E ++++ L
Sbjct: 173 HSPYLCSEEYLKRVFDTAKSLNAPVTIHLYETSKEEYDLEDI-----------LNIGLKE 221
Query: 273 NKTVMAHGCYLSAEELNVFHERGASIAHCPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVA 332
KT+ AH +L V + ++H P SNL L +G V +++H +K+ LGTD
Sbjct: 222 VKTIAAHCVHLPERYFGVLKDIPFFVSHNPASNLKLGNGIAPVQRMIEHGMKVTLGTD-- 279
Query: 333 GGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVG 392
G S + L+ + S LL N ++L + ++ T G+QA+G G E G
Sbjct: 280 GAASNNSLNLFFEMRLAS--LLQKAQNPRNLDVNTCLKMVTYDGAQAMGFKS--GKIEEG 335
Query: 393 KEFDAILINPK-----ASDSPIDLFYGDFFGDISEAVIQ-KFLYLGDD 434
D ++I+ + + F G++ ++ K++Y +
Sbjct: 336 WNADLVVIDLDLPEMFPVQNIKNHLVHAFSGEVFATMVAGKWIYFDGE 383
>2PAJ-A nrPDB
Length = 492
Score = 261 bits (666), Expect = 5e-70, Method: Composition-based stats.
Identities = 91/418 (21%), Positives = 156/418 (37%), Gaps = 46/418 (11%)
Query: 60 FKPCEIRELSHHEFFMPGLVDTHIHASQYSFAG--SSIDLPLLEWLTKYTFPAEHRFQNI 117
+P E + P V+TH H Q G + +D L WL + F
Sbjct: 54 PRPGETIVDATDCVIYPAWVNTHHHLFQSLLKGEPAGLDATLTPWLAATPYRFRALFDER 113
Query: 118 DFAEEVYTRVVRRTLKNGTTTAC-----YFATIHTDSSLLLADITDKFGQRAFV----GK 168
F + ++G T Y+ + DSS +L + +K G R +
Sbjct: 114 RF-RLAARIGLIELARSGCATVADHNYVYYPGMPFDSSAILFEEAEKLGLRFVLLRGGAT 172
Query: 169 VCMDLNDTFPE--YKETTEESIKETERFVSEMLQKNYSRVKPIVTPRFS--LSCSETLMG 224
L P ET + + + ER + + ++ +V + S S M
Sbjct: 173 QTRQLEADLPTALRPETLDAYVADIERLAARYHDASPRAMRRVVMAPTTVLYSISPREMR 232
Query: 225 ELGNIAKTRDLHIQSHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLS 284
E +A+ L + SH+SE ++ ++Y K+ + +++ L + AH +
Sbjct: 233 ETAAVARRLGLRMHSHLSETVGYQDSAYSMY--GKSPVAFCGEHDWLGSDVWYAHLVKVD 290
Query: 285 AEELNVFHERGASIAHCPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIR 344
A+E+ + + G +AHCP SN L SG V E+ V + +G D G S D I
Sbjct: 291 ADEIALLAQTGTGVAHCPQSNGRLGSGICPVREMADAGVPVSIGVD--GAASNEAADMIS 348
Query: 345 RAVM-----VSNILLINKVNEK---------SLTLKEVFRLATLGGSQALGLDGEIGNFE 390
M + + ++ + + + ++ EV T GG++ +GLD E+G
Sbjct: 349 EVHMTWLAQRARLGMLAQPAYRGGSFEGGAGAASIAEVIHWGTAGGARVMGLD-EVGKVA 407
Query: 391 VGKEFDAILINPKASDSPIDLFYGDFFGDISEAVIQKFLYLGDDRNIEEVYVGGKQVV 448
VG D A D Y V G ++ ++ GK+VV
Sbjct: 408 VGYAADI------AVYRLDDPRYFGLHDPAIGPVAS-----GGRPSVMALFSAGKRVV 454
>4LH8-A nrPDB
Length = 469
Score = 260 bits (663), Expect = 1e-69, Method: Composition-based stats.
Identities = 92/461 (19%), Positives = 160/461 (34%), Gaps = 56/461 (12%)
Query: 12 IFRGTFVHSTWTCPMEVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHH 71
+ RG T+ L D + + D KIV + K +
Sbjct: 16 LIRGLTRVITFDDQERELEDADILI-DGPKIVAVG---------KNLSDRSVSRTIDGRG 65
Query: 72 EFFMPGLVDTHIHASQYSFAGSSIDLPLLE------WLTKYTFPAEHRFQNIDFAEEVYT 125
+PGL+++H Q+ + G+ +P LE WL + +++ F +V
Sbjct: 66 MIALPGLINSH----QHLYEGAMRAIPQLERVTMASWLEGVLTRSAGWWRDGKFGPDVIR 121
Query: 126 RVVR----RTLKNGTTTAC----YFATIHTDSSL-LLADITDKFGQRAFVGKVCMDLNDT 176
V R +L G TT +F DS + + G R + M L +
Sbjct: 122 EVARAVLLESLLGGITTVADQHPFFPGATADSYIDATIEAATDLGIRFHAVRSSMTLGKS 181
Query: 177 FPEYKETTEESIKETERFVSEMLQ--------KNYSRVKPIVTPRFSLSCSETLMGELGN 228
E + ++ +R V L + + V+ + P L
Sbjct: 182 --EGGFCDDLFVEPVDRVVQHCLGLIDQYHEPEPFGMVRIALGPCGVPYDKPELFEAFAQ 239
Query: 229 IAKTRDLHIQSHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEEL 288
+A D+ + +H E D +LY +K+ +++ +AH EE+
Sbjct: 240 MAADYDVRLHTHFYEPLD-AGMSDHLY--GMTPWRFLEKHGWASDRVWLAHAVVPPREEI 296
Query: 289 NVFHERGASIAHCPNSNLSLSSGFLNVLEVLKHEVKIGLG-TDVAGGYSYSMLDAIRRAV 347
F + G +IAH +L + G + E L + +G G T A ++L +R A
Sbjct: 297 PEFADAGVAIAHLIAPDLRMGWGLAPIREYLDAGITVGFGTTGSASNDGGNLLGDLRLAA 356
Query: 348 MVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDS 407
+ N+ EK L+ +E+ R+AT G ++ LG +G E G+ D D
Sbjct: 357 LAHRPADPNE-PEKWLSARELLRMATRGSAECLGRPD-LGVLEEGRAADIACWRLDGVDR 414
Query: 408 PIDLFYGDFFGDISEAVIQKFLYLGDDRNIEEVYVGGKQVV 448
+ G V V G+ +V
Sbjct: 415 V-----------GVHDPAIGLIMTGLSDRASLVVVNGQVLV 444
>4F0L-A nrPDB
Length = 458
Score = 229 bits (583), Expect = 2e-60, Method: Composition-based stats.
Identities = 81/410 (19%), Positives = 143/410 (34%), Gaps = 61/410 (14%)
Query: 67 ELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNI--------- 117
+ + G+ + H HA QY AG L + P+ F +
Sbjct: 50 DDERQSVVVAGMANLHSHAFQYGMAG----------LAERRGPSADSFWSWREIMYKFAL 99
Query: 118 ----DFAEEVYTRVVRRTLKNGTTTACYFATIHTDSSLL----LADITDKFGQRAFVGKV 169
+ AE V R+ L+ G T F +H D L+++ D+ A +
Sbjct: 100 TMTPEQAEAVALRLYVDMLEAGFTRVGEFHYLHHDCDGTPYANLSEMADRIAAAATTAGM 159
Query: 170 CMDLNDTFPEY--------KETTEESIKETERFVS--EMLQKNYSRVKPIVTPRFSLSCS 219
+ L F + E I + ERF E +K + V S
Sbjct: 160 GLTLLPVFYAHSGFGGAAANEGQRRFINDPERFARLIEGCRKTLEGFEGAVLGVAPHSLR 219
Query: 220 ETLMGELGNIAKTR-DLHIQSHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMA 278
EL ++ + D + H++E EVE + S K + +T + +
Sbjct: 220 AVTPDELDSVTQLLPDAPVHIHVAEQVKEVEDC--IAWSGKRPVEWLLDHQDVTARWCLI 277
Query: 279 HGCYLSAEELNVFHERGASIAHCPNSNLSLSSGFLNVLEVLKHEVKIGLGTD----VAGG 334
H ++S EE + GA CP + +L G N E K G+G+D + G
Sbjct: 278 HATHMSDEETKHMAKAGAIAGLCPVTEANLGDGTFNATEFAAAGGKFGIGSDSNVLIGIG 337
Query: 335 YSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKE 394
L+ +R + +L + T + +F A LGG+ A+G + + G
Sbjct: 338 DELRQLEYSQRLYHRARNVLAAN---EGSTGRALFDGAVLGGNIAMGRPED--GLKKGAS 392
Query: 395 FDAILINPKASDSPIDLFYGDFFGDISEAVIQKFLYLGDDRNIEEVYVGG 444
D + ++ + V+ +++ G + +V+V G
Sbjct: 393 ADFVSLDVERLPHAKGDV-----------VLDGWIFAGRAH-VCDVWVRG 430
>3V7P-A nrPDB
Length = 427
Score = 205 bits (521), Expect = 3e-53, Method: Composition-based stats.
Identities = 87/431 (20%), Positives = 151/431 (35%), Gaps = 53/431 (12%)
Query: 25 PMEVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIH 84
P +++D + KI ++ K P E + +PG + H+H
Sbjct: 12 PQTIIQDKAVAF--DKKIEAIDTVENLIKKY------PNAAVEHDENSLLLPGFANPHLH 63
Query: 85 ASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTR--VVRRTLKNGTTTACYF 142
+ + + WL HR +++ + + ++ GTT
Sbjct: 64 LEFSANKATLQYGDFIPWLYSVI---RHR-EDLLPLCDGACLEQTLSSIIQTGTTAIGAI 119
Query: 143 ATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESIKETERFVSEMLQKN 202
+ S + + N + ERF +N
Sbjct: 120 S-----SYGEDLQACIDSALKVVYFNEVIGSNAATADVM-----YASFLERFHQSKKHEN 169
Query: 203 YSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKN-------LY 255
R K V S L +IAK + H E+R E E + +
Sbjct: 170 -ERFKAAVAIHSPYSVHYILAKRALDIAKKYGSLVSVHFMESRAEREWLDKGSGEFAKFF 228
Query: 256 PSYKNYTS-VYDKNNLLTN----KTVMAHGCYLSAEELNVFHERGASIAHCPNSNLSLSS 310
+ N T V D + L T+ H + + EE+ A I HCP SN L +
Sbjct: 229 KEFLNQTRPVNDTKSFLELFKELHTLFVHMVWANEEEIQTIASYNAHIIHCPISNRLLGN 288
Query: 311 GFLNVLEVLKHEVKIGLGTD-VAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVF 369
G L++ ++ + + TD ++ YS +M + ++ A L ++ E + KE+
Sbjct: 289 GVLDLEKI--KSIPYAIATDGLSSNYSLNMYEELKAA------LFVHPNKEATTFAKELI 340
Query: 370 RLATLGGSQALGLDGEIGNFEVGKEFDAILIN-PKASDSPIDLFYGDFFGDISEAVIQKF 428
AT G ALG +G G VGK+ D LI+ P+ + DL+ I K
Sbjct: 341 IRATKAGYDALGFEG--GEIAVGKDADMQLIDLPEGLTNVEDLY----LHVILHTTKPKK 394
Query: 429 LYLGDDRNIEE 439
+Y+ + ++ E
Sbjct: 395 VYIQGEEHVRE 405
>2IMR-A nrPDB
Length = 420
Score = 194 bits (493), Expect = 6e-50, Method: Composition-based stats.
Identities = 68/355 (19%), Positives = 125/355 (35%), Gaps = 54/355 (15%)
Query: 53 KLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEH 112
E + E P V+ H H ++ LP +W+ + H
Sbjct: 70 GHPDELRRQYPHAAEERAGAVIAPPPVNAHTHLDMSAYE--FQALPYFQWIPEVVIRGRH 127
Query: 113 RFQNIDFAEEVYTRVVRRTLKNGTTTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMD 172
+ + A+ + R L G +A D+ L D++ G + +
Sbjct: 128 -LRGVAAAQAGADTLTR--LGAGGVGDIVWAPEVMDALLAREDLS---------GTLYFE 175
Query: 173 LNDTFPE-YKETTEESIKETERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAK 231
+ + FP+ E + ER+ L++ R+ ++P + S LM L + A
Sbjct: 176 VLNPFPDKADEVFAAARTHLERW--RRLERPGLRL--GLSPHTPFTVSHRLMRLLSDYAA 231
Query: 232 TRDLHIQSHISENRDEVEAVKN------------LYPSYK------------NYTSVYDK 267
L +Q H++E+ E+E + LYP D+
Sbjct: 232 GEGLPLQIHVAEHPTELEMFRTGGGPLWDNRMPALYPHTLAEVIGREPGPDLTPVRYLDE 291
Query: 268 NNLLTNKTVMAHGCYLSAEELNVFHERGASIAHCPNSNLSLSSGFLNVLEVLKHEVKIGL 327
+L + + H ++ +++ G ++ CP SN L G + V++ L
Sbjct: 292 LGVLAARPTLVHMVNVTPDDIARVARAGCAVVTCPRSNHHLECGTFDWPAFAAAGVEVAL 351
Query: 328 GTD-VAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALG 381
GTD VA G + + +R V + L L + + R A GG + +G
Sbjct: 352 GTDSVASGETLN----VREEVTFARQLYP------GLDPRVLVRAAVKGGQRVVG 396
>3MDW-A nrPDB
Length = 453
Score = 162 bits (410), Expect = 2e-40, Method: Composition-based stats.
Identities = 77/403 (19%), Positives = 158/403 (39%), Gaps = 43/403 (10%)
Query: 71 HEFFMPGLVDTHIHASQYSFAGSSI-----DLPLLEWLTKYTFPAEHRFQNIDFAEEVYT 125
+PG+ + H HA Q + AG + + W + + R + + E +
Sbjct: 45 GGAVLPGMPNLHSHAFQRAMAGLAEVAGNPNDSFWTW-RELMYRMVARL-SPEQIEVIAC 102
Query: 126 RVVRRTLKNGTTTACYFATIHTD----SSLLLADITDKFGQRAFVGKVCMDLNDTFPEYK 181
++ LK G T F +H D S A+++ + + A + + L +
Sbjct: 103 QLYIEMLKAGYTAVAEFHYVHHDLDGRSYADPAELSLRISRAASAAGIGLTLLPVLYSHA 162
Query: 182 --------ETTEESIKETERFVS--EMLQKNYSRVKPIVTPRFSLSCSETLMGELGNI-- 229
E I +E ++ + L+ + F S ++ +
Sbjct: 163 GFGGQPASEGQRRFINGSEAYLELLQRLRAPLEAAGHSLGLCF-HSLRAVTPQQIATVLA 221
Query: 230 AKTRDLHIQSHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELN 289
A DL + HI+E + EV+ + S + +N + + + H + E+
Sbjct: 222 AGHDDLPVHIHIAEQQKEVDDCQA--WSGRRPLQWLYENVAVDQRWCLVHATHADPAEVA 279
Query: 290 VFHERGASIAHCPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMV 349
GA C ++ +L G + L ++G+G+D S S+++ +R
Sbjct: 280 AMARSGAVAGLCLSTEANLGDGIFPATDFLAQGGRLGIGSD--SHVSLSVVEELRWLEYG 337
Query: 350 SNILLINKV----NEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKAS 405
+ + +++ + + ++ A GG+QALG IG+ VG+ D ++++ +
Sbjct: 338 QRLRDRKRNRLYRDDQPMIGRTLYDAALAGGAQALGQP--IGSLAVGRRADLLVLD--GN 393
Query: 406 DSPIDLFYGDFFGDISEAVIQKFLYLGDDRNIEEVYVGGKQVV 448
D + GD A++ ++L+ G DR + +V V G+ VV
Sbjct: 394 DPYLASAEGD-------ALLNRWLFAGGDRQVRDVMVAGRWVV 429
>2BB0-A nrPDB
Length = 421
Score = 83.7 bits (205), Expect = 2e-16, Method: Composition-based stats.
Identities = 65/392 (16%), Positives = 128/392 (32%), Gaps = 57/392 (14%)
Query: 26 MEVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHA 85
+ V+ D ++G+ + KIVF + + + PGLVD H H
Sbjct: 32 LHVIEDAVVGIHEQ-KIVFAGQKGAEAGYE-------ADEIIDCSGRLVTPGLVDPHTH- 82
Query: 86 SQYSFAGSSIDLPLLEWLTKYTF-----PAEHRFQNIDFAEEVYTRVVR--------RTL 132
G S + + L ++ + + R L
Sbjct: 83 ---LVFGGSREKEMNLKLQGISYLDILAQGGGILSTVKDTRAASEEELLQKAHFHLQRML 139
Query: 133 KNGTTTACYF--ATIHTDSSLLLADITDKF--GQRAFVGKVCMDLNDTFPEYKETTEESI 188
GTTTA + ++ L + K Q + M + PEY+ ++ +
Sbjct: 140 SYGTTTAEVKSGYGLEKETELKQLRVAKKLHESQPVDLVSTFMGAHAIPPEYQNDPDDFL 199
Query: 189 KETERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEV 248
+ + E+ ++ + I T + S++ A ++ H DE+
Sbjct: 200 DQMLSLLPEIKEQELASFADIFTETGVFTVSQS--RRYLQKAAEAGFGLKIH----ADEI 253
Query: 249 EAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAHCPNSNLSL 308
+ + + K H S E + E G P + L
Sbjct: 254 DPLGGAELAGKLKA------------VSADHLVGTSDEGIKKLAEAGTIAVLLPGTTFYL 301
Query: 309 S-SGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKE 367
S + ++ V + L TD G S + I+ + ++ + L +T +E
Sbjct: 302 GKSTYARARAMIDEGVCVSLATDFNPGSS--PTENIQLIMSIAALHLK-------MTAEE 352
Query: 368 VFRLATLGGSQALGLDGEIGNFEVGKEFDAIL 399
++ T+ + A+G E G + G+ D ++
Sbjct: 353 IWHAVTVNAAYAIGKGEEAGQLKAGRSADLVI 384
>2P9B-A nrPDB
Length = 458
Score = 79.5 bits (194), Expect = 2e-15, Method: Composition-based stats.
Identities = 71/430 (16%), Positives = 125/430 (29%), Gaps = 60/430 (13%)
Query: 27 EVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSH-HEFFMPGLVDTHIHA 85
+LR+ + V G+I + + + P E L + MPGL++ H H
Sbjct: 29 TILRNMTIVVGADGRIEQVAPSIETS--------IPAEYHYLDGTGKIVMPGLINAHTHL 80
Query: 86 SQYSFAGSSIDLPLLEWL-----TKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTAC 140
S PL L + H + L++G TT
Sbjct: 81 F-------SQGKPLNPKLATPKGQRMVATFAHSPLGKPYMAATVKHNATTLLESGVTTIR 133
Query: 141 YFATIHTDSSLLLA--DITDKFGQRAFVGKVCMDL----NDTFPEYKETTEESIKETERF 194
+ + L D G R M + T E +
Sbjct: 134 TLGDVGYEVVTLRDQIDAGQILGPRILASGPLMAIPEGHGAPLIALTSGTPEEARTA--- 190
Query: 195 VSEMLQKNYSRVKPI----------VTPRFSLSCSETLMGELGNIAKTRDLHIQSHISEN 244
V++ L+ + +K + S S M + + A + + +H +++
Sbjct: 191 VAQNLKAGVNAIKIAATGGVTDAQEIGEAGSPQMSVEQMRAICDEAHQYGVIVGAH-AQS 249
Query: 245 RDEVEAVKNLYPSYKNYTSVYDK--NNLLTNKTVMAHG------CYLSAEELNVFHE--R 294
+ V + SV D + + G + L + +
Sbjct: 250 PEGVRRSLLAGVDTIEHGSVLDDELIGMFRHNPNALRGYSALIPTLSAGLPLTLLGQDVT 309
Query: 295 GASIAHCPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILL 354
G + NS + + + + IG+GTD + L
Sbjct: 310 GITDIQLENSKNVVGGMVSGARQAHEAGLMIGVGTDTG---------MTFVPQYATWREL 360
Query: 355 INKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDSPIDLFYG 414
V + E AT + LG+D E G+ EVGK D +++N D L +
Sbjct: 361 ELLVAYAGFSPAEALHAATAVNASILGVDAETGSLEVGKSADLLVLNANPLDDLRALEHP 420
Query: 415 DFFGDISEAV 424
V
Sbjct: 421 ALVIAAGHPV 430
>3MKV-A nrPDB
Length = 426
Score = 79.5 bits (194), Expect = 3e-15, Method: Composition-based stats.
Identities = 58/378 (15%), Positives = 108/378 (28%), Gaps = 44/378 (11%)
Query: 53 KLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEH 112
+++ + + MPGL+D H+H F +LP + L
Sbjct: 36 EVSDKPIKSSNAHVIDVKGKTIMPGLIDLHVHVVAIEF-----NLPRVATLPNVLVTLRA 90
Query: 113 RFQNIDFAEEVYTRVVRRT-----LKNGTTTACYFATIHTDSSLLLADITDKFGQRAFVG 167
+T V K + S L+ RA
Sbjct: 91 VPIMRAMLRRGFTTVRDAGGAGYPFKQAVESGLVEGPRLFVSGRALSQTGGHADPRARSD 150
Query: 168 -------KVCMDLNDTFPEYKETTEESIKETERFVSEMLQKNYSRVKPIVT----PRFSL 216
C + +E + + + V P
Sbjct: 151 YMPPDSPCGCCVRVGALGRVADGVDEVRRAVREELQMGADQIKIMASGGVASPTDPVGVF 210
Query: 217 SCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTV 276
SE + + A+ R ++ +H AV+ + + T + V
Sbjct: 211 GYSEDEIRAIVAEAQGRGTYVLAHAYTPAAIARAVR----CGVRTIEHGNLIDDETARLV 266
Query: 277 MAHGCYLSAEEL--NVFHERGASIAHCPNSNLSL----SSGFLNVLEVLKHEVKIGLGTD 330
HG Y+ + + G P S + +G ++ + + VK+G GTD
Sbjct: 267 AEHGAYVVPTLVTYDALASEGEKYGLPPESIAKIADVHGAGLHSIEIMKRAGVKMGFGTD 326
Query: 331 VAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFE 390
+ G D R + L+ EV AT+ ++ LG+ ++G
Sbjct: 327 LLGEAQRLQSDEFRILA-------------EVLSPAEVIASATIVSAEVLGMQDKLGRIV 373
Query: 391 VGKEFDAILINPKASDSP 408
G D ++++ S
Sbjct: 374 PGAHADVLVVDGNPLKSV 391
>4CQD-A nrPDB
Length = 423
Score = 77.6 bits (189), Expect = 1e-14, Method: Composition-based stats.
Identities = 66/414 (15%), Positives = 139/414 (33%), Gaps = 38/414 (9%)
Query: 28 VLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQ 87
++R+ L DS + + + K+ + + + + PG VD H H +
Sbjct: 28 IIRNAYLSEKDSVYDIGIV-GDRIIKIEAKIEGTVKDEID-AKGNLVSPGFVDAHTHMDK 85
Query: 88 YSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTACYFATIHT 147
F + LP W YT + + + ++R + T++T
Sbjct: 86 S-FTSTGERLPKF-WSRPYT-RDAAIEDGLKYYKNATHEEIKRHVIEHAHMQVLHGTLYT 142
Query: 148 DSSLLLADITDKFGQRAFV-GKVCMDLNDTFPEYKETTEESIKETERFVSEMLQKNYS-R 205
+ + + + A + K + + E +
Sbjct: 143 RTHVDVDSVAKTKAVEAVLEAKEELKDLIDIQVVAFAQSGFFVDLESESLIRKSLDMGCD 202
Query: 206 VKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKNLYPSYKNYTSVY 265
+ V P + E + +AK D+ I HI + +Y S
Sbjct: 203 LVGGVDPATRENNVEGSLDLCFKLAKEYDVDIDYHIHDI-----GTVGVY-SINRLAQKT 256
Query: 266 DKNNLLTNKTVMAHGCYLS------AEELNVFHERGASIAHCPNSNLSLSSGFLNVLEVL 319
+N T A C+ E + ++ + G C +S + V+++L
Sbjct: 257 IENGYKGRVTTSAAWCFADAPSEWLDEAIPLYKDSGMKFVTCFSSTPP----TMPVIKLL 312
Query: 320 KHEVKIGLGTD------VAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLAT 373
+ + +G +D V G D ++ A++ + L + + L ++++ T
Sbjct: 313 EAGINLGCASDNIRDFWVPFGNG----DMVQGALIETQRLELKTNRDLGL----IWKMIT 364
Query: 374 LGGSQALGLDGEIGNFEVGKEFDAILINPKASDSPIDLFYGDFFGDISEAVIQK 427
G++ LG++ G EVGK+ D +++N + I + +I K
Sbjct: 365 SEGARVLGIEKNYG-IEVGKKADLVVLNSLSPQWAIIDQAKRLCVIKNGRIIVK 417
>2PUZ-A nrPDB
Length = 419
Score = 77.2 bits (188), Expect = 1e-14, Method: Composition-based stats.
Identities = 65/398 (16%), Positives = 118/398 (29%), Gaps = 64/398 (16%)
Query: 29 LRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQY 88
+ + ++ V + G+I F S + + P L+D H H
Sbjct: 37 VENAVIAVRN-GRIAFAGPESDLPD-----DLSTADETTDCGGRWITPALIDCHTH---- 86
Query: 89 SFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRR-------------TLKNG 135
G + + L T+ + + TR + L G
Sbjct: 87 LVFGGNRAMEFEMRLNGATYEEIAKAGGGIVSSVRDTRALSDEVLVAQALPRLDTLLSEG 146
Query: 136 TTTA----CYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESIKET 191
+T Y I T+ +L + + + + + T +YK + I +
Sbjct: 147 VSTIEIKSGYGLDIETELKMLRVARRLETLRPVRIVTSYLAAHATPADYKGRNADYITDV 206
Query: 192 -----ERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRD 246
E+ +E L + S E + A+ R L ++ H +E
Sbjct: 207 VLPGLEKAHAEGLADAVDGFCEGIA----FSVKEI--DRVFAAAQQRGLPVKLH-AEQLS 259
Query: 247 EVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAHCPNSNL 306
+ + Y N H YL + G P +
Sbjct: 260 NLG--------GAELAASY-------NALSADHLEYLDETGAKALAKAGTVAVLLPGAFY 304
Query: 307 SL-SSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTL 365
+L V + +I L TD G S + + M + + +T+
Sbjct: 305 ALREKQLPPVQALRDAGAEIALATDCNPGTS-PLTSLLLTMNMGATLFR--------MTV 355
Query: 366 KEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPK 403
+E T ++ALGL E G E GK D + + +
Sbjct: 356 EECLTATTRNAAKALGLLAETGTLEAGKSADFAIWDIE 393
>2OOF-A nrPDB
Length = 416
Score = 76.0 bits (185), Expect = 3e-14, Method: Composition-based stats.
Identities = 63/389 (16%), Positives = 127/389 (32%), Gaps = 50/389 (12%)
Query: 28 VLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQ 87
+L H LGV + G+I L + P +++ + PGL+D H H
Sbjct: 26 LLEPHALGVHE-GRIHALVPMQDLKG------PYPAHWQDMKG-KLVTPGLIDCHTHLIF 77
Query: 88 YSFAGSSIDLPLLEWLTKYTFPAEH---------RFQNIDFAEEVYTRVVRRTLKNGTTT 138
+L R + D E+ V+ ++ G TT
Sbjct: 78 AGSRAEEFELRQKGVPYAEIARKGGGIISTVRATRAASEDQLFELALPRVKSLIREGVTT 137
Query: 139 ACYF--ATIHTDSSLLLADITDKFG--QRAFVGKVCMDLNDTFPEYKETTEESIKET-ER 193
+ + L + + + G V + + PEY++ + ++ +
Sbjct: 138 VEIKSGYGLTLEDELKMLRVARRLGEALPIRVKTTLLAAHAVPPEYRDDPDSWVETICQE 197
Query: 194 FVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKN 253
+ + + + S ++T ++ A L ++ H+
Sbjct: 198 IIPAAAEAGLADAVDVFCEHIGFSLAQT--EQVYLAADQYGLAVKGHM----------DQ 245
Query: 254 LYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAHCPNSNLSL-SSGF 312
L + + L+ H YL E + RG P + L +
Sbjct: 246 LSNLGGSTLA--ANFGALSVD----HLEYLDPEGIQALAHRGVVATLLPTAFYFLKETKL 299
Query: 313 LNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLA 372
V+ + K V + + +D+ + + ++R A+ ++ L LT E
Sbjct: 300 PPVVALRKAGVPMAVSSDI--NPGTAPIVSLRMAMNMACTLF-------GLTPVEAMAGV 350
Query: 373 TLGGSQALGLDGEIGNFEVGKEFDAILIN 401
T ++ALG ++G VG D ++ N
Sbjct: 351 TRHAARALGEQEQLGQLRVGMLADFLVWN 379
>4WGX-A nrPDB
Length = 465
Score = 63.7 bits (153), Expect = 1e-10, Method: Composition-based stats.
Identities = 68/462 (14%), Positives = 145/462 (31%), Gaps = 100/462 (21%)
Query: 12 IFRGTFVHSTWTCPMEVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHH 71
I GT + P+ + + + D G+I + Q E P + +
Sbjct: 7 IVGGTLIDGNGGVPVP---ETTVFIED-GRITKVGSTDQIE-------VHPNIRQIDAQG 55
Query: 72 EFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRT 131
++ +PGLV+ ++H + L RF+ + +V +
Sbjct: 56 KWILPGLVNGNVHLLDGIMMMGRGGIEYL-----------ARFEGNYY--KVIEEAAQIA 102
Query: 132 LKNGTTTACYFATIHTDSSLLLADITD--KFGQRAFVGKVCMDLNDTF------PEYKET 183
L+ G TT ++ I G R F + + F P +
Sbjct: 103 LRGGVTTVFDTWNALEPVTIARDRIASGAAEGARIFFAGTLIGMGGPFTGDFMRPSMQAR 162
Query: 184 TEESIKETER-----------------------FVSEMLQKNYSRVKPIVTPRFS----- 215
T S +R + E L++ K VT
Sbjct: 163 TVMSRTFADRMDAMFEVGMGRHLSTLPPAEVRPLIREYLERGVDFCKIAVTDHLVGLLGF 222
Query: 216 ----LSCSETLMGELGNIAKTRDLHIQSHISE-----NRDEVEAVKNLYPS--YKNYTSV 264
+ SE ++ L + + + + +H + E +A ++ + +
Sbjct: 223 RAPYFTFSERVLDVLVDEVRRAGVPLLTHTTSLEGLNTAIERDADLMIHATMTGQAPIPE 282
Query: 265 YDKNNLLTNKTV-------MAHGCYLSAEELNVFHERGASIAHCPNSNLSLSSGFLNVLE 317
LL + +A ++ + + + F + + H N +
Sbjct: 283 ETIEKLLEKQLWSEVQPTTIAQQAWMDSVD-HPFADFSGRVHH------------ENDVR 329
Query: 318 VLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNI--------LLINKVNEKSLTLKEVF 369
++K V + LGTD AG +L+ + + + + + + EK +
Sbjct: 330 MIKAGVPLVLGTD-AGCTDPDILEDMSQGELHERPWTLGEDHFVWMQAMVEKGMDPMAAI 388
Query: 370 RLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDSPIDL 411
T ++A E+G+ +VGK D ++++ ++
Sbjct: 389 LAGTANPAKAYRKFDELGSIDVGKLGDVVVLDQDPLADITNM 430
>1R9X-A nrPDB
Length = 430
Score = 62.9 bits (151), Expect = 3e-10, Method: Composition-based stats.
Identities = 53/395 (13%), Positives = 114/395 (28%), Gaps = 55/395 (13%)
Query: 34 LGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQYSFAGS 93
+ + D GKI ++ S E + +P V+ HIH AG
Sbjct: 26 IHLQD-GKISAIDAQSGVM--------PITENSLDAEQGLVIPPFVEPHIHLDTTQTAGQ 76
Query: 94 ---SIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTACYFATIHTDSS 150
+ L E + + D ++ + ++ + NG + +
Sbjct: 77 PNWNQSGTLFEGIE--RWAERKALLTHDDVKQRAWQTLKWQIANGIQHVRTHVDVSDATL 134
Query: 151 LLLADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESIKETERFVSEMLQKNYSRVKPIV 210
L + + +DL + + S E + E L+
Sbjct: 135 TALKAMLEVK----QEVAPWIDLQIV--AFPQEGILSYPNGEALLEEALR--LGADVVGA 186
Query: 211 TPRFSLSCSE--TLMGELGNIAKTRDLHIQSHISENRDEVEAVKNLYPSYKNYTSVYDKN 268
P F + + + +A+ D I H E DE + + +
Sbjct: 187 IPHFEFTREYGVESLHKTFALAQKYDRLIDVHCDEIDDEQSR-------FVETVAALAHH 239
Query: 269 NLLTNKTVMAHGCYL-------SAEELNVFHERGASIAHCPNSNLSLSS---------GF 312
+ + +H + ++ + G + P N+ L G
Sbjct: 240 EGMGARVTASHTTAMHSYNGAYTSRLFRLLKMSGINFVANPLVNIHLQGRFDTYPKRRGI 299
Query: 313 LNVLEVLKHEVKIGLGTDVAGG--YSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFR 370
V E+L+ + + G D Y + ++ M ++ + + + +
Sbjct: 300 TRVKEMLESGINVCFGHDGVFDPWYPLGTANMLQVLHMGLHVCQLMGYGQ----INDGLN 355
Query: 371 LATLGGSQALGLDGEIGNFEVGKEFDAILINPKAS 405
L T ++ L L G + I++ +
Sbjct: 356 LITHHSARTLNLQDY--GIAAGNSANLIILPAENG 388
>3N2C-A nrPDB
Length = 423
Score = 61.0 bits (146), Expect = 1e-09, Method: Composition-based stats.
Identities = 65/416 (15%), Positives = 131/416 (31%), Gaps = 47/416 (11%)
Query: 28 VLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQ 87
VL +H V D +IV ++ P + MPG +D H+H
Sbjct: 20 VLLEHHHVVIDGERIV---------EVTDRPVDLPNAQAIDVRGKTVMPGFIDCHVHVLA 70
Query: 88 Y-SFAGSSIDLP-------LLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTA 139
+ G + P L L ++ A+ + V L +G
Sbjct: 71 SNANLGVNATQPNILAAIRSLPILDAMLSRGFTSVRDAGGADWSLMQAVETGLVSGPR-- 128
Query: 140 CYFATIHTDSSLLLADITDKFGQRAFVGKVCMD-LNDTFPEYKETTEESIKE-TERFVSE 197
+ + + D + + E +++E ++ ++
Sbjct: 129 IFPSGKALSQTGGHGDFRPRGDLLEPCSCCFRTGAIARVVDGVEGVRLAVREEIQKGATQ 188
Query: 198 MLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKNLYPS 257
+ V P + SE + + + A+ + ++ +H R AV+
Sbjct: 189 IKIMASGGVASPTDPIANTQYSEDEIRAIVDEAEAANTYVMAHAYTGRAIARAVR----C 244
Query: 258 YKNYTSVYDKNNLLTNKTVMAHG--CYLSAEELNVFHERGASIAHCPNSNLSLSS----G 311
+ + K + HG + + + GA P S ++S G
Sbjct: 245 GVRTIEHGNLVDEAAAKLMHEHGAFVVPTLVTYDALAKHGAEFGMPPESVAKVASVQQKG 304
Query: 312 FLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRL 371
++ VK+G G+D+ G R + + L E R
Sbjct: 305 RESLEIYANAGVKMGFGSDLLGEMHAFQSGEFR-------------IRAEVLGNLEALRS 351
Query: 372 ATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDSPIDLFYGDFFGDISEAVIQK 427
AT ++ + + G++G VG D ++++ + D+ G E V+Q+
Sbjct: 352 ATTVAAEIVNMQGQLGVIAVGAIADLVVLD---GNPLEDIGVVADEGARVEYVLQR 404
>3MTW-A nrPDB
Length = 403
Score = 59.9 bits (143), Expect = 2e-09, Method: Composition-based stats.
Identities = 67/423 (15%), Positives = 123/423 (29%), Gaps = 101/423 (23%)
Query: 31 DHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQYSF 90
D+ L + G+I + + +L +PGL+D H+H +
Sbjct: 21 DNPLVIVTDGRITSIGKKGDA-------VPAGATAVDLPG-VTLLPGLIDMHVHLDSLAE 72
Query: 91 AGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTACYFATIHTDSS 150
G L RF ++ V T ++TL+ G TT D
Sbjct: 73 VGGYNSLEY-----------SDRFWSV-----VQTANAKKTLEAGFTTVRNVGAADYDDV 116
Query: 151 LLLADITDKF--GQRAFVGK----------------VCMDLNDTF-PEYKETTEESIKET 191
L I + G R MD + F + + ++++
Sbjct: 117 GLREAIDAGYVPGPRIVTAAISFGATGGHCDSTFFPPSMDQKNPFNSDSPDEARKAVRTL 176
Query: 192 ERFVSEMLQ--KNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVE 249
+++ +++++ P + M + + A + + +H E
Sbjct: 177 KKYGAQVIKICATGGVFSRGNEP-GQQQLTYEEMKAVVDEAHMAGIKVAAHAHGASGIRE 235
Query: 250 AVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAHCP------- 302
AV+ + H + E + + ++GA +
Sbjct: 236 AVRA----GVDTIE---------------HASLVDDEGIKLAVQKGAYFSMDIYNTDYTQ 276
Query: 303 ---NSNLSLSSGF-----------LNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVM 348
N L N + LK VK+ GTD V
Sbjct: 277 AEGKKNGVLEDNLRKDRDIGELQRENFRKALKAGVKMVYGTDAGIYPHGDNAKQFAVMVR 336
Query: 349 VSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDSP 408
T + + ATL ++ALG ++G VG+ D I + A D
Sbjct: 337 Y------------GATPLQAIQSATLTAAEALGRSKDVGQVAVGRYGDMIAV---AGDPL 381
Query: 409 IDL 411
D+
Sbjct: 382 ADV 384
>4WHB-E nrPDB
Length = 461
Score = 59.5 bits (142), Expect = 3e-09, Method: Composition-based stats.
Identities = 63/429 (14%), Positives = 126/429 (29%), Gaps = 63/429 (14%)
Query: 30 RDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHA--SQ 87
R + + + + + + + +PG V+ ++H +
Sbjct: 20 RPATTVIVEGDRFATVGPSDSTP-------VPEGATVVDGNRRWMVPGYVNGNVHLLDAW 72
Query: 88 YSFAGSSIDLPLLEWLTKYT--FPAEHRFQNIDFAEEVYT--------RVVRRTLKNGTT 137
AG L W +Y + + V+ R + G +
Sbjct: 73 MFMAGPGTIEYLARWEGRYVEVIEEAAQLALRNGVTTVFDTHNAIEPVLAARDRINAGIS 132
Query: 138 TAC-YFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESI---KETER 193
FA F R + +D D+ E + S+ KE
Sbjct: 133 QGARIFAAGTIVGMGGPFSADFHFAGRTAATRTFVDRIDSMFEAGVGHQLSLLPRKEVRA 192
Query: 194 FVSEMLQKNYSRVKPIVTPRFSLSC--------------SETLMGELGNIAKTRDLHIQS 239
V + L + +K V+ + S ++ + A+ + + +
Sbjct: 193 RVRDYLSRGVDMLKIAVSDHIVFTLVDRSVGFDRSYQTFSRPVLEVMVEEARAAGVPVLT 252
Query: 240 H-----ISENRDEVEA---VKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCY-LSAEELNV 290
H + E+ A + Y + + + ++ + + L
Sbjct: 253 HSVSVEALDTSVELGADVLIHANYTLGQEIPNYLIDKIVASDSWAGLQTVHDQHRQGLED 312
Query: 291 FHERGASIAHCPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVS 350
A++A P + N ++ KI L TD AG S L +
Sbjct: 313 VGSWAAALAGEPYAT--------NERNLISANAKILLNTD-AGCPSKDHLADLSPVERED 363
Query: 351 NI--------LLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINP 402
+ EK ++ E AT+ ++A G +IG+ E GK D +L++
Sbjct: 364 RPWTIGNDHFHWTQSMVEKGMSPLEAISAATINVARAYGKADQIGSVETGKLADFVLLDQ 423
Query: 403 KASDSPIDL 411
D +L
Sbjct: 424 DPVDDIRNL 432
>4C65-A nrPDB
Length = 438
Score = 56.8 bits (135), Expect = 2e-08, Method: Composition-based stats.
Identities = 76/467 (16%), Positives = 139/467 (29%), Gaps = 88/467 (18%)
Query: 14 RGTFVHSTWTCPM--EVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHH 71
+ T +++ P E LR+ L +SD I F+ + K +
Sbjct: 6 KVTIIYAGLLIPGDGEPLRNAALVISDK-IIAFVGSEADIPKKYLRSTQSTHRV------ 58
Query: 72 EFFMPGLVDTHIHASQYSFAGSSIDL--PLLEWLTKYTFPAEHRFQN--IDFAEEVYTRV 127
MPGL D H+H G D L + + R + + YT
Sbjct: 59 PVLMPGLWDCHMHF------GGDDDYYNDYTSGLATHPASSGARLARGCWEALQNGYT-S 111
Query: 128 VRRTLKNGT-------TTACYFATIHTDSSLL--LADITDKFGQRAFVGKVCMDLNDTFP 178
R G +++ + L A D F A + + P
Sbjct: 112 YRDLAGYGCEVAKAINDGTIVGPNVYSSGAALSQTAGHGDIFALPAGEVLGSYGVMNPRP 171
Query: 179 EYKETTEESIKETERFVSEMLQKNYSRVKPIVTPRFSLSC------------SETLMGEL 226
Y I + V ++ R ++ S S + +
Sbjct: 172 GYWGAGPLCIADGVEEVRRAVRLQIRRGAKVIKVMASGGVMSRDDNPNFAQFSPEELKVI 231
Query: 227 GNIAKTRDLHIQSHISENRDEVEAVK-------NLYPSYKNYTSVYDKNNLLTNKTVMAH 279
A ++ + +H+ + A+K ++ + + + + +L T
Sbjct: 232 VEEAARQNRIVSAHVHGKAGIMAAIKAGCKSLEHVSYADEEVWELMKEKGILYVATRSVI 291
Query: 280 GCYLSAEELNVFHERGASIAHCPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSM 339
+L++ + E A + +S+L G +K V I LGTD A G
Sbjct: 292 EIFLASNGEGLVKESWAKLQALADSHLKAYQG------AIKAGVTIALGTDTAPGGP--- 342
Query: 340 LDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEI-GNFEVGKEFDAI 398
+ + L V +T E + AT ++G + G G E D I
Sbjct: 343 ----------TALELQFAVERGGMTPLEAIKAATANAPLSVGPQAPLTGQLREGYEADVI 392
Query: 399 LINPKASDSPIDLFYGDFFGDISEAVIQKFLYLGDDRNIEEVYVGGK 445
+ E ++ + + + V+ GGK
Sbjct: 393 ALE--------------------ENPLEDIKVFQEPKAVTHVWKGGK 419
>2QS8-A nrPDB
Length = 418
Score = 54.1 bits (128), Expect = 1e-07, Method: Composition-based stats.
Identities = 56/385 (14%), Positives = 110/385 (28%), Gaps = 68/385 (17%)
Query: 64 EIRELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEV 123
+ +L H PGL+D H+H Q + + +E + +H +
Sbjct: 52 DYIDLRDHTVL-PGLMDMHVHFGQ-EYQSKAQAPIKVEREMQAILATQHAYVTFKSGFTT 109
Query: 124 YTRVVRRTLKNGTTTACYFATIHTDSSLLLA--DITDKFGQR-AFVGKVCMDLNDTFPEY 180
+V L + + + A I G GK D + PE
Sbjct: 110 VRQVGDSGLVAISLRDAINSGKLAGPRIFAAGKTIATTGGHADPTNGKAVDDYDYPVPEQ 169
Query: 181 KETTEESIKETERFVSEMLQKNYSRVKPIVTPRF--------SLSCSETLMGELGNIAKT 232
E V + + +K VT + ++ + + + AK
Sbjct: 170 GVVNGPY--EVYAAVRQRYKDGADGIKITVTGGVLSVAKSGQNPQFTQEEVDAVVSAAKD 227
Query: 233 RDLHIQSHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFH 292
+ + H E +K + + HG ++ E +++
Sbjct: 228 YGMWVAVHAH----GAEGMKRAIKAGVDSIE---------------HGTFMDLEAMDLMI 268
Query: 293 ERGASIAHCPNSNLSLS-----SGFLN-----------------VLEVLKHEVKIGLGTD 330
E G ++ ++ F + + VKI GTD
Sbjct: 269 ENGTYYVPTISAGEFVAEKSKIDNFFPEIVRPKAASVGPQISDTFRKAYEKGVKIAFGTD 328
Query: 331 VAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFE 390
+ V E + + + AT+ ++ L ++ ++G+ E
Sbjct: 329 AGVQKHGTNWKEFVYMV------------ENGMPAMKAIQSATMETAKLLRIEDKLGSIE 376
Query: 391 VGKEFDAILINPKASDSPIDLFYGD 415
GK D I + + L D
Sbjct: 377 SGKLADLIAVKGNPIEDISVLENVD 401
>2OGJ-A nrPDB
Length = 417
Score = 49.1 bits (115), Expect = 4e-06, Method: Composition-based stats.
Identities = 65/403 (16%), Positives = 124/403 (30%), Gaps = 90/403 (22%)
Query: 34 LGVSDSGKIVFLEEASQQEKLAKEWCFKPCEI-RELSHHEFFMPGLVDTHIHASQYSFAG 92
+ + GKI + A Q P + R + F PG VD H+H
Sbjct: 38 ILIGGDGKIAAVGSALQA----------PADTQRIDAKGAFISPGWVDLHVH-------- 79
Query: 93 SSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTACYFATIHTDSSLL 152
+I +E R V + G+ F +
Sbjct: 80 ---------------IWHGGTDISIRPSECGAERGVTTLVDAGSAGEANFHGF---REYI 121
Query: 153 LADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESIKETERFVSEMLQKNYSRVKPIVTP 212
+ ++ +G + + + PE ++ + + +R + + + V V
Sbjct: 122 IEPSRERIKAFLNLGSIGLVACNRVPELRDIKD---IDLDRILECYAENSEHIVGLKVRA 178
Query: 213 RFSLSCS--ETLMGELGNIAKTRDLHIQSHISENRDEVEAVKNLYPSYKNYTSVYDK-NN 269
++ S T + IAK + + H+ E ++YD+
Sbjct: 179 SHVITGSWGVTPVKLGKKIAKILKVPMMVHVGE-----------------PPALYDEVLE 221
Query: 270 LLTNKTVMAHGCY-------LSAEELNVFHERGASIAHCPNSNLSL------SSGFLNVL 316
+L V+ H + E+L ER C + L +S V
Sbjct: 222 ILGPGDVVTHCFNGKSGSSIMEDEDLFNLAER------CAGEGIRLDIGHGGASFSFKVA 275
Query: 317 EVLKHE--VKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATL 374
E + + TD+ G+S + A +S +L ++ + + V T
Sbjct: 276 EAAIARGLLPFSISTDLH-GHSMN-FPVWDLATTMSKLLSVD------MPFENVVEAVTR 327
Query: 375 GGSQALGLDGEIGNFEVGKEFDAILINPKASDSPIDLFYGDFF 417
+ + LD E +VG+ D + + +D GD
Sbjct: 328 NPASVIRLDME-NRLDVGQRADFTVFDLVDADLEATDSNGDVS 369
>3OOQ-A nrPDB
Length = 396
Score = 49.1 bits (115), Expect = 5e-06, Method: Composition-based stats.
Identities = 59/370 (15%), Positives = 118/370 (31%), Gaps = 46/370 (12%)
Query: 44 FLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWL 103
L + EK+ + EI +L+ +F PG VD H H + G
Sbjct: 26 VLVSNGKVEKVGENIEDPDAEIVDLTG-KFLFPGFVDAHSHIGLFE-EGVGYYYSDGNEA 83
Query: 104 TKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTACYFATIHTDSSLLLADITDKFGQR 163
T P + + R L G T+ I S+ + R
Sbjct: 84 TDPVTPHVKALDGFNPQDPAIERA----LAGGVTSVM----IVPGSANPVGGQGSVIKFR 135
Query: 164 AFVGKVCMDLNDTFPEYKETTEESIKETERFVSEMLQKNYSRVKPIVTPRFSLSCSETLM 223
+ + + C+ P + + +R E Q +R+ R + + M
Sbjct: 136 SIIVEECI---VKDPAGLKMA--FGENPKRVYGERKQTPSTRMGTAGVIRDYFTKVKNYM 190
Query: 224 GELGNIAKTRD-----LHIQSHISENRDEVEAVKNLYPSYKN----YTSVYDKNNLLTNK 274
+ +A+ ++ + E + ++ + + ++
Sbjct: 191 KK-KELAQKEGKEFTETDLKMEVGEMVLRKKIPARMHAHRADDILTAIRIAEEFGF---N 246
Query: 275 TVMAHGCYLSAEELNVFHERGASIAHCP----NSNLSLSSGFLN-VLEVLKHEVKIGLGT 329
V+ HG V E+ + P + L L + + ++LK V I L
Sbjct: 247 LVIEHGTEAYKIS-KVLAEKKIPVVVGPLLTFRTKLELKDLTMETIAKLLKDGVLIALMC 305
Query: 330 DVAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNF 389
D ++ V + + E + ++ T+ ++ LGL+ IG+
Sbjct: 306 DHP------VIPLEFATVQAATAMRYGAKEED------LLKILTVNPAKILGLEDRIGSI 353
Query: 390 EVGKEFDAIL 399
E GK+ D ++
Sbjct: 354 EPGKDADLVV 363
>1XRT-A nrPDB
Length = 467
Score = 48.3 bits (113), Expect = 7e-06, Method: Composition-based stats.
Identities = 62/423 (14%), Positives = 123/423 (29%), Gaps = 95/423 (22%)
Query: 23 TCPMEVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTH 82
P + L + ++GKI + + P + PG +D H
Sbjct: 57 IDPSQNLEGEFDILVENGKIKKI----------DKNILVPEAEIIDAKGLIVCPGFIDIH 106
Query: 83 IHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTACYF 142
+H P + ++I+ + G TT
Sbjct: 107 VHL---------------------RDPGQTYKEDIESGSRCA-------VAGGFTTIVCM 138
Query: 143 ATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESIKETERFVSEMLQKN 202
+ ++ + T ++ + K
Sbjct: 139 PNTNPPIDNTTVVNYILQKSKSVGLCRVL---------PTGTITKGRKGKEIADFYSLKE 189
Query: 203 YSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISE--------NRDEVEAVKNL 254
V T S ++M + +A + I H + N EV A+ L
Sbjct: 190 AGCV--AFTDDGSPVMDSSVMRKALELASQLGVPIMDHCEDDKLAYGVINEGEVSALLGL 247
Query: 255 YPSYKNYTSV-YDKNNLLTNKTV-MAHGCYLSA----EELNVFHERGASIAHCPNSNLSL 308
+ ++ +L +T H ++S E + F E+G I N N L
Sbjct: 248 SSRAPEAEEIQIARDGILAQRTGGHVHIQHVSTKLSLEIIEFFKEKGVKITCEVNPNHLL 307
Query: 309 -------SSGF-----LNVLEVLKH-----EVKIGL----GTDVAGGYSYSMLDAIRRAV 347
+SG + + VK G+ TD A ++ +
Sbjct: 308 FTEREVLNSGANARVNPPLRKKEDRLALIEGVKRGIIDCFATDHAPHQTFE--KELVEFA 365
Query: 348 MVSNILLINKVN-------EKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILI 400
M I L + + ++LK++ + T+ ++ +G+D +G ++G D +
Sbjct: 366 MPGIIGLQTALPSALELYRKGIISLKKLIEMFTINPARIIGVD--LGTLKLGSPADITIF 423
Query: 401 NPK 403
+P
Sbjct: 424 DPN 426
>1YRR-A nrPDB
Length = 382
Score = 44.1 bits (102), Expect = 1e-04, Method: Composition-based stats.
Identities = 62/401 (15%), Positives = 120/401 (29%), Gaps = 72/401 (17%)
Query: 27 EVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHAS 86
E L DH + ++D G I + ++ E R L+ PG +D
Sbjct: 14 EFLDDHAVVIAD-GLIKSVCPVAEL--------PPEIEQRSLNG-AILSPGFIDVQ---- 59
Query: 87 QYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTACYFATIH 146
G +F + A V T + + + Y T+
Sbjct: 60 ---LNGCGG----------------VQFNDTAEAVSVETLEIMQKANEKSGCTNYLPTL- 99
Query: 147 TDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEYKETT-----------EESIKETERFV 195
+ +D K G R + N + E +++ + +
Sbjct: 100 ----ITTSDELMKQGVRVMREYLAKHPNQALGLHLEGPWLNLVKKGTHNPNFVRKPDAAL 155
Query: 196 SEMLQKNYSRV-KPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKNL 254
+ L +N + K + P + + + G + + ++
Sbjct: 156 VDFLCENADVITKVTLAPEMVPAEVISKLANAGIVVSAGHSNATLKEAKAGFRAGITFAT 215
Query: 255 YPSYKNYTSVYDKNNLLTNKT--------VMAHGCYLSAEELNVFHERGASIAHCPNSNL 306
+ + L ++A G ++ + +R C ++
Sbjct: 216 HLYNAMPYITGREPGLAGAILDEADIYCGIIADGLHVDYANIRN-AKRLKGDKLCLVTDA 274
Query: 307 SLSSGFLNVLEVLKHEVKI----GLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNEKS 362
+ +G N+ + + I GL D G S S L I N V
Sbjct: 275 TAPAG-ANIEQFIFAGKTIYYRNGLCVDENGTLSGSSLTMIEGVR--------NLVEHCG 325
Query: 363 LTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPK 403
+ L EV R+ATL ++A+G++ +G GK + P
Sbjct: 326 IALDEVLRMATLYPARAIGVEKRLGTLAAGKVANLTAFTPD 366
>1NFG-A nrPDB
Length = 457
Score = 44.1 bits (102), Expect = 1e-04, Method: Composition-based stats.
Identities = 67/423 (15%), Positives = 130/423 (30%), Gaps = 64/423 (15%)
Query: 17 FVHSTWTCPMEVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMP 76
+ + + + LG+ D GKI + A P E + + P
Sbjct: 4 IIKNGTIVTADGISRADLGIKD-GKITQIGGA-----------LGPAERTIDAAGRYVFP 51
Query: 77 GLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVR----RTL 132
G +D H H SF S D + + + ++ +
Sbjct: 52 GGIDVHTHVETVSFNTQSADTFATATVAAACG-GTTTIVDFCQQDRGHSLAEAVAKWDGM 110
Query: 133 KNGTTTACYFATI----HTDSSLLLADITDKFGQ---RAFVGKVCMDLNDTFPEYKETTE 185
G + Y I TDS + ++ G + F+ M++ D +T +
Sbjct: 111 AGGKSAIDYGYHIIVLDPTDSVIEELEVLPDLGITSFKVFMAYRGMNMIDDV-TLLKTLD 169
Query: 186 ESIKETERFVSEMLQKN---YSRVKPIVTPRF---------SLSCSETLMGELGNIAKTR 233
+++K + + Y R K + + +A+
Sbjct: 170 KAVKTGSLVMVHAENGDAADYLRDKFVAEGKTAPIYHALSRPPRVEAEATARALALAEIV 229
Query: 234 DLHIQS-HIS--ENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNV 290
+ I H++ E+ +EV K+ + H YL+ E+L
Sbjct: 230 NAPIYIVHVTCEESLEEVMRAKS------RGVRALAE--------TCTHYLYLTKEDLER 275
Query: 291 FHERGASIAHCPNSNLS---------LSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLD 341
GA P + L +G + H + G G + +
Sbjct: 276 PDFEGAKYVFTPPARAKKDHDVLWNALRNGVFETVS-SDHCSWLFKGHKDRGRNDFRAIP 334
Query: 342 AIRRAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILIN 401
V +++ VNE ++L + L ++ G+ + G VG + D +L +
Sbjct: 335 NGAPGVEERLMMVYQGVNEGRISLTQFVELVATRPAKVFGMFPQKGTIAVGSDADIVLWD 394
Query: 402 PKA 404
P+A
Sbjct: 395 PEA 397
>6NBO-A nrPDB
Length = 402
Score = 43.3 bits (100), Expect = 2e-04, Method: Composition-based stats.
Identities = 56/401 (13%), Positives = 109/401 (27%), Gaps = 49/401 (12%)
Query: 45 LEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLT 104
L E + + P E +PGLV+ H H + + + W
Sbjct: 28 LIEGDRIARTGPSLDAPPGCAIEEGAGAIALPGLVEGHTHLDKTHWG--------MPWYR 79
Query: 105 KYTFP---------AEHRFQNIDFAEEVYTRVVRRTLKNGTTTACYFATIHTDSSLLLAD 155
P +R + A + R L GTT + D+ L
Sbjct: 80 NAVGPRLVDRIENERHYRATSGHDAGAASLALARAFLAAGTTRIRTHVDV--DTDAGLRH 137
Query: 156 ITDKFGQRAFVGKVCMDLNDTFPEYKETTEESIKETERFVSEMLQKNYSRVKPIVTPRFS 215
+ R + FP+ + + + + + P
Sbjct: 138 LHRVLDTRETLRGQVEIQIVAFPQSG----VLKRPGTDALLADALAAGADLLGGLDPCAI 193
Query: 216 LSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKT 275
+ L IA+ + H+ E +L + +K
Sbjct: 194 EGDPVKAVDVLFGIAERYGRGLDLHLHERGSMGAYSLDLI------LQRTAALG-MQHKV 246
Query: 276 VMAHGCYLS-------AEELNVFHERGASIAHCPNSNLSLSSGFLNVLEVLKHEVKIGLG 328
++H L L E G ++ + + + S VL V + G
Sbjct: 247 TISHAFCLGDLAERERDALLARMAELGVAVVTTAPAAVPVPS----VLACRAAGVTVIGG 302
Query: 329 TDVAGG--YSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEI 386
D Y D + RA++++ + + L+ T G ++ G D
Sbjct: 303 NDGVRDTWTPYGSPDMLERAMLIAMRNDFRRDDA----LEVALECVTHGAARGCGFDAY- 357
Query: 387 GNFEVGKEFDAILINPKASDSPIDLFYGDFFGDISEAVIQK 427
+ G D +L++ + S ++ +
Sbjct: 358 -GLQPGARADVVLVDAMTLAEAVVARPVRRLVVSSGKIVAR 397
>6AJD-A nrPDB
Length = 485
Score = 43.3 bits (100), Expect = 2e-04, Method: Composition-based stats.
Identities = 66/416 (15%), Positives = 113/416 (27%), Gaps = 52/416 (12%)
Query: 60 FKPCEIRELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQN-ID 118
C++ + ++ MPG +D H H Q F G+ + +
Sbjct: 38 PSGCDVLD-GGGQYLMPGGIDPHTHM-QLPFMGTVASEDFFSGTAAGLAGGTTSIIDFVI 95
Query: 119 FAEEVYTRVVRRTLKNGTTTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFP 178
T + + H + ++ + G V + ++ F
Sbjct: 96 PNPRQSLLEAFHTWRGWAQKSAADYGFHVAITWWSDEVAREMG--ELVAQHGVNSFKHFM 153
Query: 179 EYKE----TTEESIKETER------------------FVSEMLQKNYSRVKPIVTPRF-S 215
YK + + ER F + P P
Sbjct: 154 AYKNAIMAADDTLVASFERCLELGAVPTVHAENGELVFHLQQKLLAQGLTGPEAHPLSRP 213
Query: 216 LSCSETLMGELGNIAKTRDLHIQ-SHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNK 274
IA+T + HIS E Y V + LL +
Sbjct: 214 PQVEGEAASRAIRIAETLGTPLYLVHISSREALDEIAYARAKGQPVYGEVLAGH-LLLDD 272
Query: 275 TVMAHGCYLSAEELNVFHERGASIAHCPNSNLSLSSGFLNVLEVLKH----EVKIGLGTD 330
+V H + +A V + H L SG L+ H + +G D
Sbjct: 273 SVYRHPDWATAAGY-VMSPPFRPVEHQEALWRGLQSGNLHTTA-TDHCCFCAEQKAMGRD 330
Query: 331 VAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFE 390
R + L VN L++ E L + ++ L G
Sbjct: 331 DFSKIPNGTAGIEDRMAL----LWDAGVNSGRLSMHEFVALTSTNTAKIFNLFPRKGAIR 386
Query: 391 VGKEFDAILINPKASDSP----------IDLFYGDFFGDISEAVIQK--FLYLGDD 434
VG + D +L +P+ S + ++F G I I + L+ D
Sbjct: 387 VGADADLVLWDPQGSRTLSAATHHQRVDFNIFEGRTVRGIPSHTISQGKLLWAAGD 442
>3EWD-A nrPDB
Length = 370
Score = 43.3 bits (100), Expect = 2e-04, Method: Composition-based stats.
Identities = 20/142 (14%), Positives = 49/142 (34%), Gaps = 18/142 (12%)
Query: 213 RFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLT 272
E+ + + + + H E+ + + LY + + ++
Sbjct: 198 HGGHEVDLKEYKEIFDYVRESGVPLSVHAGEDVT-LPNLNTLYSAIQ--VLKVERIG--- 251
Query: 273 NKTVMAHGCYL--SAEELNVFHERGASIAHCPNSNLSLSSG----FLNVLEVLKHEVKIG 326
HG + S E +++ E+ + CP SN+ L + + ++ VK+
Sbjct: 252 ------HGIRVAESQELIDMVKEKNILLEVCPISNVLLKNAKSMDTHPIRQLYDAGVKVS 305
Query: 327 LGTDVAGGYSYSMLDAIRRAVM 348
+ +D G + ++ D
Sbjct: 306 VNSDDPGMFLTNINDDYEELYT 327
>6II7-A nrPDB
Length = 367
Score = 42.1 bits (97), Expect = 4e-04, Method: Composition-based stats.
Identities = 25/142 (17%), Positives = 51/142 (35%), Gaps = 18/142 (12%)
Query: 213 RFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLT 272
++ + + + I H E+ S N S+Y NLL
Sbjct: 203 HAGHEVDLKPFKDIFDNIREEGISISVHAGEDV-----------SIPNLNSLYTAINLLH 251
Query: 273 NKTVMAHGCYLSAEE--LNVFHERGASIAHCPNSNLSLSS----GFLNVLEVLKHEVKIG 326
K + HG +S + +++ E+ + CP SN+ L++ + + VK+
Sbjct: 252 VKRI-GHGIRVSESQELIDLVKEKDILLEVCPISNVLLNNVKSMDTHPIRMLYDAGVKVS 310
Query: 327 LGTDVAGGYSYSMLDAIRRAVM 348
+ +D G + ++ D
Sbjct: 311 VNSDDPGMFLTNITDNYEELYT 332
>2AMX-A nrPDB
Length = 376
Score = 41.4 bits (95), Expect = 9e-04, Method: Composition-based stats.
Identities = 21/109 (19%), Positives = 44/109 (40%), Gaps = 18/109 (16%)
Query: 231 KTRDLHIQSHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEE--L 288
+ LH+ H E+ N ++Y N+L + + HG +S + +
Sbjct: 230 RDHGLHLTVHAGEDAT-----------LPNLNTLYTAINILNVERI-GHGIRVSESDELI 277
Query: 289 NVFHERGASIAHCPNSNLSLSS----GFLNVLEVLKHEVKIGLGTDVAG 333
+ ++ + CP SNL L++ + ++ VK+ + +D G
Sbjct: 278 ELVKKKDILLEVCPISNLLLNNVKSMDTHPIRKLYDAGVKVSVNSDDPG 326
>2VUN-A nrPDB
Length = 386
Score = 41.0 bits (94), Expect = 0.001, Method: Composition-based stats.
Identities = 56/397 (14%), Positives = 101/397 (25%), Gaps = 65/397 (16%)
Query: 28 VLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQ 87
VL+ + V D G I + + + PGL+DTH+H S
Sbjct: 21 VLQADTIVVED-GLIAAIGGEELMKDAGDA-------TIIDAAGSTVTPGLLDTHVHVS- 71
Query: 88 YSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTR-VVRRTLKNGTTTACYFATIH 146
D+A T + L G TT + H
Sbjct: 72 ----------------------------GGDYAPRQKTMDFISSALHGGVTTMISAGSPH 103
Query: 147 TDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESIKETERFVSE-MLQKNYSR 205
D G +A + + P + ++ + E ++
Sbjct: 104 FPG-----RPKDAAGTKALAITLSKSYYNARPAGVKVHGGAVILEKGLTEEDFIEMKKEG 158
Query: 206 VKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKNLYPSYKNYTSVY 265
V + + + A +Q H + K V
Sbjct: 159 VWIVGEVGLGTIKNPEDAAPMVEWAHKHGFKVQMHTGGTSIPGSSTVTADDVIKTKPDVV 218
Query: 266 DKNNLLTNKTVMAHGCY--LSAEELNVFHERGASIAHCPNSNLSLSSGFLNVLEVLKHEV 323
N + + + + I C N ++
Sbjct: 219 SHIN-GGPTAISVQEVDRIMDETDFAM------EIVQC--GNPKIADYVARRAAEKGQLG 269
Query: 324 KIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLD 383
++ G D G L +R ++++ + + +AT + GL+
Sbjct: 270 RVIFGNDAPSGTGLIPLGILRNMCQIASM--------SDIDPEVAVCMATGNSTAVYGLN 321
Query: 384 GEIGNFEVGKEFDAILINPKASDSPIDLFYGDFFGDI 420
G GKE D I+++ D GDI
Sbjct: 322 --TGVIAPGKEADLIIMDTPLGSVAEDAMGAIAAGDI 356
>3E74-A nrPDB
Length = 473
Score = 41.0 bits (94), Expect = 0.001, Method: Composition-based stats.
Identities = 54/424 (12%), Positives = 126/424 (29%), Gaps = 67/424 (15%)
Query: 28 VLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQ 87
++++ + + + ++V + + + E+ + S PG+VD H H S+
Sbjct: 26 IIKNGTVILENEARVVDIAVKGGKIAAIGQDLGDAKEVMDASG-LVVSPGMVDAHTHISE 84
Query: 88 ------------YSFAGSSIDLPLLEW-LTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKN 134
A ++E L + + + F +
Sbjct: 85 PGRSHWEGYETGTRAAAKGGITTMIEMPLNQLPATVDRASIELKFDAAKGKLTIDAAQLG 144
Query: 135 GTTTACYFATIHTDSSLLLADITDKFGQRAFVG-KVCMDLNDTFPEYKE----------- 182
G + D L ++ G + FV +++ F + +
Sbjct: 145 GLVSYNI------DRLHELDEV-GVVGFKCFVATCGDRGIDNDFRDVNDWQFFKGAQKLG 197
Query: 183 --TTEESIKETERFVSEMLQKNYSRVKPIVTPRFSLSCSE-----TLMGELGNIAKTRDL 235
+ + + L + R + VT ++ + + +AK
Sbjct: 198 ELGQPVLVHCENALICDELGEEAKR-EGRVTAHDYVASRPVFTEVEAIRRVLYLAKVAGC 256
Query: 236 HIQ-SHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHER 294
+ H+S + + VE V ++ T + + + EE+ +
Sbjct: 257 RLHVCHVS-SPEGVEEVTRARQEGQDITCESCPHYFVLDTDQF--------EEIGTLAK- 306
Query: 295 GASIAHCPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVA-------GGYSYSMLDAIRRAV 347
C L + ++ E+ L +D + G I
Sbjct: 307 ------CSPPIRDLENQKGMWEKLFNGEIDC-LVSDHSPCPPEMKAGNIMKAWGGIAGLQ 359
Query: 348 MVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDS 407
+++ V ++ ++L +L + GL + G GK+ D + I P +S
Sbjct: 360 SCMDVMFDEAVQKRGMSLPMFGKLMATNAADIFGLQQK-GRIAPGKDADFVFIQPNSSYV 418
Query: 408 PIDL 411
+
Sbjct: 419 LTND 422
>1YNY-A nrPDB
Length = 461
Score = 38.7 bits (88), Expect = 0.005, Method: Composition-based stats.
Identities = 56/386 (14%), Positives = 112/386 (29%), Gaps = 94/386 (24%)
Query: 74 FMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLK 133
+PG +D H H + + R
Sbjct: 50 VIPGGIDPHTHLDM--------------------------PFGGTVTADDFFTGTRAAAF 83
Query: 134 NGTTTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESIKETER 193
GTT+ F SL A T R GK +D E ++ ++E E
Sbjct: 84 GGTTSIVDFCLTKKGESLKSAIATWHEKAR---GKAVIDYGFHL-MIAEANDQVLEELES 139
Query: 194 FVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKN 253
+S + + +K + + + + + AK +Q H +EN D ++ +
Sbjct: 140 VISS---EGITSLKVFMAYKNVFQADDETLFKTLVKAKELGALVQVH-AENGDVLDYLTK 195
Query: 254 ----------LYPSYKNYTSVYDK--------NNLLTNKTVMAHGCYLSAEELNVFHER- 294
+Y +Y + L ++ + H SA + E
Sbjct: 196 KALAEGNTDPIYHAYTRPPEAEGEATGRAIALTALAGSQLYVVHVSCASA--VQRIAEAR 253
Query: 295 ----GASIAHCPNSNLSLSSGFLNVLEV-----------------------LKHEVKIGL 327
CP L+L ++ + LK+ + +
Sbjct: 254 EKGWNVYGETCPQY-LALDVSIMDQPDFEGAKYVWSPPLREKWNQEVLWSALKNGILQTV 312
Query: 328 GTD-----------VAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATLGG 376
G+D + G + + IL V + ++L + +++
Sbjct: 313 GSDHCPFNFRGQKELGRGDFTKIPNGGPLIEDRLTILYSEGVRQGRISLNQFVDISSTKA 372
Query: 377 SQALGLDGEIGNFEVGKEFDAILINP 402
++ G+ G VG + D ++ +P
Sbjct: 373 AKLFGMFPRKGTIAVGSDADIVIFDP 398
>3IV8-A nrPDB
Length = 381
Score = 38.7 bits (88), Expect = 0.006, Method: Composition-based stats.
Identities = 18/73 (24%), Positives = 30/73 (41%), Gaps = 8/73 (10%)
Query: 329 TDVAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGN 388
D G S L I N V + L E R+ATL ++A+G+D ++G
Sbjct: 300 VDENGTLGGSALTMIEAV--------QNTVEHVGIALDEALRMATLYPAKAIGVDEKLGR 351
Query: 389 FEVGKEFDAILIN 401
+ G + + +
Sbjct: 352 IKKGMIANLTVFD 364
>1GKQ-A nrPDB
Length = 458
Score = 37.5 bits (85), Expect = 0.012, Method: Composition-based stats.
Identities = 35/222 (15%), Positives = 71/222 (31%), Gaps = 36/222 (16%)
Query: 46 EEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTK 105
E ++ + P + ++ PG +D H+H LP +
Sbjct: 22 AEGETITRIGQNLEAPPGTEVIDATGKYVFPGFIDPHVHIY----------LPFMA---- 67
Query: 106 YTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTACYFATIHTDSSLLLADITDKFGQRAF 165
FA++ + + L GTTT I D + +
Sbjct: 68 ------------TFAKDTHETGSKAALMGGTTT-----YIEMCCPSRNDDALEGYQLWKS 110
Query: 166 VGKVCMDLNDTFPEYKETTEESIKETERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGE 225
+ + TF +E +TE + E++ S K ++ + + M +
Sbjct: 111 KAEGNSYCDYTFHMAVSKFDE---KTEGQLREIVADGISSFKIFLSYKNFFGVDDGEMYQ 167
Query: 226 LGNIAKTRDLHIQSHISENRDEVEAV-KNLYPSYKNYTSVYD 266
+AK + + +H EN + V + + L K ++
Sbjct: 168 TLRLAKELGVIVTAHC-ENAELVGRLQQKLLSEGKTGPEWHE 208
Score = 37.1 bits (84), Expect = 0.015, Method: Composition-based stats.
Identities = 12/53 (22%), Positives = 23/53 (43%)
Query: 351 NILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPK 403
N+L V+ L + A+ ++ GL G VG + D ++ +P+
Sbjct: 345 NLLYTYGVSRGRLDIHRFVDAASTKAAKLFGLFPRKGTIAVGSDADLVVYDPQ 397
>3T8L-A nrPDB
Length = 608
Score = 36.4 bits (82), Expect = 0.025, Method: Composition-based stats.
Identities = 32/180 (17%), Positives = 60/180 (33%), Gaps = 35/180 (19%)
Query: 269 NLLTNKTVMAHGCYLSAEELNVFHERGASIAHCPNSNLSLSSGFLNVLEVLKHEVKIGLG 328
L K V H L +LN F G S S+ L SG E L +++ GL
Sbjct: 211 GLAAEKLVCGHARGLKNADLNAFMAAGVS------SDHELVSG-----EDLMAKLRAGLT 259
Query: 329 TDVAGGYS---------YSMLDAI-RRAVMVSNILLINKVNEKS-------------LTL 365
++ G + + L + + + ++ + + + + L
Sbjct: 260 IELRGSHDHLLPEFVAALNTLGHLPQTVTLCTDDVFPDDLLQGGGLDDVVRRLVRYGLKP 319
Query: 366 KEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDSPIDLFYGDFFGDISEAVI 425
+ R ATL +Q LG ++G G+ D ++ S + ++
Sbjct: 320 EWALRAATLNAAQRLGR-SDLGLIAAGRRADIVVFEDLNGFSARHVLASGRAVAEGGRML 378
>4CEX-C nrPDB
Length = 570
Score = 36.4 bits (82), Expect = 0.029, Method: Composition-based stats.
Identities = 16/52 (30%), Positives = 23/52 (44%)
Query: 352 ILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPK 403
L K + LK T+ + A G+ E+G+ E GK D +L PK
Sbjct: 390 PLAEEKNGSDNFRLKRYVSKYTINPAIAQGIAHEVGSIEEGKFADLVLWEPK 441
>2VHL-A nrPDB
Length = 396
Score = 36.4 bits (82), Expect = 0.030, Method: Composition-based stats.
Identities = 58/409 (14%), Positives = 128/409 (31%), Gaps = 89/409 (21%)
Query: 27 EVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHAS 86
EV+++ +G++D GKI + +E +KE P + +PG++D HIH
Sbjct: 17 EVIKNGYVGIND-GKISTVSTERPKEPYSKE-IQAPAD-------SVLLPGMIDIHIHG- 66
Query: 87 QYSFAGSSIDLPLLEW-LTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTACYFATI 145
+ ++D + P E T ++G + +
Sbjct: 67 --GYGADTMDASFSTLDIMSSRLPEEGT---------TSFLATTITQEHGNISQA----L 111
Query: 146 HTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPE---YKETTEESIKETE-RFVSEMLQK 201
A+ + G + + L F +E I+ ++ + Q+
Sbjct: 112 VNAREWKAAEESSLLG----AELLGIHLEGPFVSPKRAGAQPKEWIRPSDVELFKKWQQE 167
Query: 202 NYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKNLYPSYKNY 261
+K + + + I +D I + + + + + +
Sbjct: 168 AGGLIKIV-------TLAPEEDQHFELIRHLKDESIIASMGHTDADSALLSDAAKAG--- 217
Query: 262 TSVYDKNNLLTNKTVMAHGCYLSAEELNVFHE----RGASIAHCPNSNLSLSSGF----- 312
+H +L H G ++AH ++ G
Sbjct: 218 ---------------ASHMTHLYNAMSPFHHREPGVIGTALAHDGFVTELIADGIHSHPL 262
Query: 313 -LNVLEVLKHEVKIGLGTDVAGGYSY---------SMLDAIRRAVMVSNILLINKV---N 359
+ + K K+ L TD + R ++S+ L + N
Sbjct: 263 AAKLAFLAKGSSKLILITDSMRAKGLKDGVYEFGGQSVTVRGRTALLSDGTLAGSILKMN 322
Query: 360 EKSLTLKE--------VFRLATLGGSQALGLDGEIGNFEVGKEFDAILI 400
E + ++E + + + ++ LG+ G+ VGK+ D +++
Sbjct: 323 EGARHMREFTNCSWTDIANITSENAAKQLGIFDRKGSVTVGKDADLVIV 371
>5NKS-A nrPDB
Length = 573
Score = 36.0 bits (81), Expect = 0.036, Method: Composition-based stats.
Identities = 43/266 (16%), Positives = 81/266 (30%), Gaps = 51/266 (19%)
Query: 67 ELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTR 126
+H +PG VD H PA+ + +
Sbjct: 59 IDAHGLMVLPGGVDVHTRLQMPVLG---------------MTPADD-----------FCQ 92
Query: 127 VVRRTLKNGTTTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEYKETTEE 186
+ L GTT + D+ + L +++ +RA C + + + T
Sbjct: 93 GTKAALAGGTTMILDH--VFPDTGVSLLAAYEQWRERADSAACC-----DYSLHVDITRW 145
Query: 187 SIKETERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRD 246
E + + +K + + + CS++ M E+ +I + Q H +EN D
Sbjct: 146 HESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQMYEIFSIIRDLGALAQVH-AENGD 204
Query: 247 EVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASI---AHCPN 303
VE + + + + H E R +I A+CP
Sbjct: 205 IVEEEQK----------RLLELGITGPE---GHVLSHPEEVEAEAVYRAVTIAKQANCPL 251
Query: 304 SNLS-LSSGFLNVLEVLKHEVKIGLG 328
+S G + + K + G
Sbjct: 252 YVTKVMSKGAADAIAQAKRRGVVVFG 277
>3IGH-X nrPDB
Length = 486
Score = 36.0 bits (81), Expect = 0.040, Method: Composition-based stats.
Identities = 10/44 (22%), Positives = 23/44 (52%), Gaps = 1/44 (2%)
Query: 358 VNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILIN 401
+++L +K+ T G ++ L +IG E G + + I+++
Sbjct: 429 TKDQALDIKDALHSYTYGSARV-SLASDIGKLEPGFKAEYIILD 471
Score = 32.5 bits (72), Expect = 0.41, Method: Composition-based stats.
Identities = 39/285 (13%), Positives = 87/285 (30%), Gaps = 23/285 (8%)
Query: 17 FVHSTWTCPMEVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMP 76
++ T L+ V GK+++ ++ +K+ + EI +L ++ MP
Sbjct: 6 LINGTIYTSFNPLKKVSGLVISHGKVIYAGDSEVAKKIVELSGG---EIVDLKG-KYVMP 61
Query: 77 GLVDTHIH-------ASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVR 129
D+H+H G+ L++ L + F D E +
Sbjct: 62 AFFDSHLHLDELGMSLEMVDLRGAKSIEELIQRLKRGKGRIIFGF-GWDQDELGEWPTRK 120
Query: 130 RTLKNGTTTACYFATIHTDSSLLLADITDKFGQ---RAFVGKVCMDLNDTFPEYKETTEE 186
N + ++ + + + F + + E ++ E
Sbjct: 121 EL--NAIDKPVFIYRKCFHVAVANDKMLELLNLTPSKDFDEDTGIIKEKSLEEARKVINE 178
Query: 187 SIKETERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHIS---E 243
+ E +V + + + V +S +E + L + + L I E
Sbjct: 179 RVLTVEDYVYYIKRAQEHLLDLGVKSVSFMSVNEKALRALFYLEREGKLSINVFAYVTPE 238
Query: 244 NRDEVEAVKNLYPSYKNYT---SVYDKNNLLTNKTVMAHGCYLSA 285
D++E++ T + L +T + Y
Sbjct: 239 VLDKLESIGLGRFQGNRLTIAGVKLFTDGSLGARTALLSKPYSDD 283
>4Z42-C nrPDB
Length = 572
Score = 35.2 bits (79), Expect = 0.068, Method: Composition-based stats.
Identities = 12/31 (38%), Positives = 19/31 (61%)
Query: 373 TLGGSQALGLDGEIGNFEVGKEFDAILINPK 403
T+ + A G+ IG+ EVGK D +L +P+
Sbjct: 413 TINPAIAQGVSHVIGSVEVGKMADLVLWDPR 443
>3MPG-A nrPDB
Length = 428
Score = 34.4 bits (77), Expect = 0.097, Method: Composition-based stats.
Identities = 69/424 (16%), Positives = 129/424 (30%), Gaps = 96/424 (22%)
Query: 35 GVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSH--HEFFMPGLVDTHIHASQYSFAG 92
+++ GKIV + Q K+AK + E+ + PGLVD H+H +
Sbjct: 10 YMNEEGKIVATDLLVQDGKIAKVAENITADNAEVIDVNGKLIAPGLVDVHVHLREPG--- 66
Query: 93 SSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTACYFATI--HTDSS 150
EH+ E K G TT C D
Sbjct: 67 -----------------GEHK--------ETIETGTLAAAKGGFTTICAMPNTRPVPDCR 101
Query: 151 LLLADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESIKETERFVSEMLQKNYSRVKPIV 210
+ D+ ++ ++A V + P T ++ E F + ++ V
Sbjct: 102 EHMEDLQNRIKEKAHV--------NVLPYGAITVRQAGSEMTDFETLKELGAFAFTDDGV 153
Query: 211 TPRFSLSCSETLMGELGNIAKTRDLHIQSH-----------ISENRDEVEAVKNLYPSYK 259
+ + ++M A ++ + +H + E + + N PS
Sbjct: 154 GVQDA-----SMMLAAMKRAAKLNMAVVAHCEENTLINKGCVHEGKFSEKHGLNGIPSVC 208
Query: 260 NYTSVYDKNNLLTNKTVMAHGCYLSAEE----LNVFHERGASI---------AHC----- 301
+ L H C++S + + G + C
Sbjct: 209 ESVHIARDILLAEAADCHYHVCHVSTKGSVRVIRDAKRAGIKVTAEVTPHHLVLCEDDIP 268
Query: 302 -PNSNLSLSSGFLNVLEVLKHEVKIG---------LGTDVAGGYSYSMLDAIRRA----- 346
+ N ++ + HE I + TD A + I RA
Sbjct: 269 SADPNFKMNP---PLRGKEDHEALIEGLLDGTIDMIATDHAPHTAEEKAQGIERAPFGIT 325
Query: 347 --VMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKA 404
+L N V + +TL+++ + T + GL E G + G+ D +I+ +
Sbjct: 326 GFETAFPLLYTNLVKKGIITLEQLIQFLTEKPADTFGL--EAGRLKEGRTADITIIDLEQ 383
Query: 405 SDSP 408
+
Sbjct: 384 EEEI 387
>1RK6-A nrPDB
Length = 496
Score = 34.4 bits (77), Expect = 0.12, Method: Composition-based stats.
Identities = 8/52 (15%), Positives = 16/52 (30%)
Query: 40 GKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQYSFA 91
G++ + + + R + PG +D+H H Y
Sbjct: 38 GRLADVGVRGDRIAAVGDLSASSARRRIDVAGKVVSPGFIDSHTHDDNYLLK 89
>5XGX-A nrPDB
Length = 395
Score = 34.1 bits (76), Expect = 0.14, Method: Composition-based stats.
Identities = 62/410 (15%), Positives = 124/410 (30%), Gaps = 80/410 (19%)
Query: 23 TCPMEVLRDHLLGVSD----SGKIVFLEEASQQE-KLAKEWCFKPCEIRELSHHEFFMPG 77
C + + + LG+ D KI + + Q E + K+W K PG
Sbjct: 11 LCNVNIYAPNPLGIKDVLIAGNKIAAIYDHGQGEITIPKQWPVKVINF----DGAILTPG 66
Query: 78 LVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTT 137
+D+H H G + FA +V + G T
Sbjct: 67 FIDSHAHI--TGGGGQAG-----------------------FATQVPPVGLTEFTHAGVT 101
Query: 138 TACYFATIHTDSSLLLADITDKF------GQRAFVGKVCMDL-NDTFPEYKETTEESIKE 190
T D++ ++ + G A+ T ++ ++
Sbjct: 102 TVVGLLG-TDDTTRSTENLLSRVYGLREEGLSAYCWTGGYHFPLTTITGSAKSDIAFLEP 160
Query: 191 T---ERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDE 247
F + + + ++ + + G+ G I H+ +
Sbjct: 161 VIGIGEFAISDHRSSQPTFEEVIRLASETHVAGLITGKAGV--------IHFHLGDGERR 212
Query: 248 VEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAHC--PNSN 305
+E ++ + V++ ++ NK + E+ +G I P
Sbjct: 213 LELIERAIRETELPARVFNPTHVNRNKPLF--------EDSCKLLSKGCHIDLTAFPAGT 264
Query: 306 LSLSSGFLNVLEVL-KHEVK---IGLGTDVAG--------GYSYSMLDAIRRAVMVSNIL 353
+ +E+ + ++ I L +D G G M RA + L
Sbjct: 265 AQPGWEACDAIEMAVERQLPLEQITLSSDGGGCLPCFDPQGELQHM--DFGRASTLGETL 322
Query: 354 LINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPK 403
+ K L+L+ V + T + L + G VG + D +++N K
Sbjct: 323 VATLN--KGLSLETVLPMLTSNVANILRFKNK-GQIAVGFDADLLVMNEK 369
>4LCQ-A nrPDB
Length = 520
Score = 34.1 bits (76), Expect = 0.14, Method: Composition-based stats.
Identities = 12/63 (19%), Positives = 21/63 (33%), Gaps = 10/63 (15%)
Query: 34 LGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQYSFAGS 93
+ + GKIV + + P + +PG +DTH H
Sbjct: 45 VHIR-GGKIVEVGP---------DLRVPPGARVIDATDRLVIPGGIDTHTHMELAFMGTR 94
Query: 94 SID 96
++D
Sbjct: 95 AVD 97
>2ICS-A nrPDB
Length = 379
Score = 33.7 bits (75), Expect = 0.17, Method: Composition-based stats.
Identities = 53/371 (14%), Positives = 114/371 (30%), Gaps = 64/371 (17%)
Query: 54 LAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHR 113
+A E L + G +D H+H + Y +P E
Sbjct: 32 VAATISGSAKETIHLEPGTYVSAGWIDDHVHCFEKMAL-------------YYDYPDEI- 77
Query: 114 FQNIDFAEEVYTRVVRRTLKNGTTTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMDL 173
+ V + GTT A IH L T+ FG + K +
Sbjct: 78 ---------GVKKGVTTVIDAGTTGAE---NIHEFYDLAQQAKTNVFGL-VNISKWGIVA 124
Query: 174 NDTFPEYKETTEESIKETERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTR 233
D + + +K+ + + + + +R+ V ++ L ++ + +
Sbjct: 125 QDELADLSKVQASLVKKAIQELPDFVVGIKARMSRTVIGDNGITP-LELAKQIQQ--ENQ 181
Query: 234 DLHIQSHISENRDEVEAVKNLYPSYKNYTSVYD--KNNLLTNKTVMAHGCYLSAEELNVF 291
++ + HI ++ + L T ++ +N +L T +++ F
Sbjct: 182 EIPLMVHIGSAPPHLDEILALMEKGDVLTHCFNGKENGILDQAT----------DKIKDF 231
Query: 292 H--ERGASIAHCPNSNLSLSSGF----LNVLE-VLKHEVKIG-LGTDVAGGYSYSMLDAI 343
+ + G +V E L+ +K + TD+ + +
Sbjct: 232 AWQAYNKGVV------FDIGHGTDSFNFHVAETALREGMKAASISTDIYIRNREN--GPV 283
Query: 344 RRAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPK 403
L + + E+ T ++ L + G E+GK+ D + +
Sbjct: 284 YDLATTMEKLRVVGYDWP-----EIIEKVTKAPAENFHLTQK-GTLEIGKDADLTIFTIQ 337
Query: 404 ASDSPIDLFYG 414
A + + G
Sbjct: 338 AEEKTLTDSNG 348
>1E9Y-B nrPDB
Length = 569
Score = 33.3 bits (74), Expect = 0.25, Method: Composition-based stats.
Identities = 14/50 (28%), Positives = 24/50 (48%)
Query: 353 LLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINP 402
L K + + +K T+ + A G+ +G+ EVGK D +L +P
Sbjct: 390 LKEEKGDNDNFRIKRYLSKYTINPAIAHGISEYVGSVEVGKVADLVLWSP 439
>4H9M-A nrPDB
Length = 840
Score = 32.9 bits (73), Expect = 0.28, Method: Composition-based stats.
Identities = 11/59 (18%), Positives = 24/59 (40%)
Query: 345 RAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPK 403
+ + L + + + ++ T+ + A G +G+ EVGK D ++ P
Sbjct: 653 KMKAQTGPLKCDSSDNDNFRIRRYIAKYTINPAIANGFSQYVGSVEVGKLADLVMWKPS 711
>3SFW-A nrPDB
Length = 461
Score = 32.9 bits (73), Expect = 0.33, Method: Composition-based stats.
Identities = 58/425 (13%), Positives = 122/425 (28%), Gaps = 93/425 (21%)
Query: 34 LGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQYSFAGS 93
+ SD+ + L + + + + E+ + + + + +PG +D H H
Sbjct: 11 VTASDTYQADVLIDGEKVVAIGSDLQATDAEVIDATGY-YLLPGGIDPHTHLDM------ 63
Query: 94 SIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTACYFATIHTDSSLLL 153
+ + + GTT+ F SL
Sbjct: 64 --------------------PFGGTVTSDNFFTGTKAAAFGGTTSIVDFCLTSKGESLHS 103
Query: 154 ADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESIKETERFVSEMLQKNYSRVKPIVTPR 213
A T R GK +D + + ++E E V+ + + +K + +
Sbjct: 104 AIATWHEKAR---GKAVIDYGFHL-MVSDANDHVLEELESVVN---NEGITSLKVFMAYK 156
Query: 214 FSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKN----------LYPSYKNYTS 263
L + + + AK +Q H +EN D ++ + +Y +Y
Sbjct: 157 NVLMADDETLFKTLIRAKELGALVQVH-AENGDVLDYLTKQALAEGNTDPIYHAYTRPPE 215
Query: 264 VYDK--------NNLLTNKTVMAHGCYLSAEELNVFHER-----GASIAHCPN------- 303
+ L + + H A + E CP
Sbjct: 216 AEGEATGRAIALTALADAQLYVVHVSCADA--VRRIAEAREKGWNVYGETCPQYLVLDIT 273
Query: 304 ----SNLSLSSGFL--NVLEVL---------KHEVKIGLGTDVAGGYSYSMLDAIRRAVM 348
+ + + E K+ + +G+D + RR
Sbjct: 274 ALEKPDFEGAKYVWSPPLREKWNQDVLWSALKNGILQTVGSDHCPFNFSGQKELGRRDFT 333
Query: 349 -----------VSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDA 397
IL V + ++L + + + ++ G+ + G VG + D
Sbjct: 334 KIPNGGPIIEDRMTILFSEGVRKGKISLNQFVDITSTKVAKLFGMFPQKGTIAVGSDADI 393
Query: 398 ILINP 402
+L +P
Sbjct: 394 VLFDP 398
>3S9V-A nrPDB
Length = 785
Score = 32.5 bits (72), Expect = 0.40, Method: Composition-based stats.
Identities = 18/133 (13%), Positives = 36/133 (27%), Gaps = 8/133 (6%)
Query: 170 CMDLNDTFPEYKETTEESIKETERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNI 229
M L + + + R ++ + V L L +
Sbjct: 218 IMKLQSKDGSFLSSPASTAAVFMRTGNKKCLDFLNFVLKKFGNHVPCHYPLDLFERLWAV 277
Query: 230 AKTRDLHIQSHISENRDEVEAV-------KNLYPSYKNYTSVYDKNNLLTNKTVMAHGCY 282
L I H E E + + + +N D + + + HG
Sbjct: 278 DTVERLGIDRHFKEEIKEALDYVYSHWDERGIGWARENPVPDIDDTA-MGLRILRLHGYN 336
Query: 283 LSAEELNVFHERG 295
+S++ L F +
Sbjct: 337 VSSDVLKTFRDEN 349
>4G7E-B nrPDB
Length = 840
Score = 32.5 bits (72), Expect = 0.41, Method: Composition-based stats.
Identities = 12/59 (20%), Positives = 22/59 (37%)
Query: 345 RAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPK 403
+ L + + +K T+ + A G +G+ EVGK D ++ P
Sbjct: 653 KMKSARGPLQPGEEANDNFRIKRYVAKYTINPAIANGFSQYVGSVEVGKLADLVMWKPS 711
>3TAC-A nrPDB
Length = 361
Score = 32.5 bits (72), Expect = 0.44, Method: Composition-based stats.
Identities = 39/272 (14%), Positives = 76/272 (27%), Gaps = 14/272 (5%)
Query: 25 PMEVLR---DHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDT 81
P V+R + G + KIV + + + L+ E + I + H + L
Sbjct: 38 PFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKHPHIVELLETY 97
Query: 82 HIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTACY 141
Y L + A+ F + Y R + L+
Sbjct: 98 SSDGMLYMVFEFMDGADLC---FEIVKRADAGFVYSEAVASHYMRQILEALRYCHDNNII 154
Query: 142 FATIHTDSSLLLADI------TDKFGQRAFVGKVCMDLNDTFPEYKETTEESIKETERFV 195
+ LL + FG +G+ + E +K
Sbjct: 155 HRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFMAPEVVKREPYGK 214
Query: 196 SEMLQKNYSRVKPIVTPRFS-LSCSETLMGELGNIAKTRDLHIQSHISENRDE-VEAVKN 253
+ + +++ E L + + SHISE+ + V +
Sbjct: 215 PVDVWGCGVILFILLSGCLPFYGTKERLFEGIIKGKYKMNPRQWSHISESAKDLVRRMLM 274
Query: 254 LYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSA 285
L P+ + + L + A+ +L
Sbjct: 275 LDPAERITVYEALNHPWLKERDRYAYKIHLPE 306
>4OTK-A nrPDB
Length = 318
Score = 32.1 bits (71), Expect = 0.58, Method: Composition-based stats.
Identities = 18/78 (23%), Positives = 33/78 (42%), Gaps = 2/78 (2%)
Query: 370 RLATLGGSQALGLDGEIGNFEVG-KEFDAILINPKASDSPIDLFYGDFFGDISEAVIQKF 428
+A++ G Q +G E E G +I +N + + + L + D +E +
Sbjct: 20 HMASMTGGQQMGRGSEFVTGESGAAAAPSITLNDEHTMPVLGLGVAELSDDETERAVSAA 79
Query: 429 LYLGDDRNIEEVYVGGKQ 446
L +G R I+ Y G +
Sbjct: 80 LEIG-CRLIDTAYAYGNE 96
>1FWC-C nrPDB
Length = 567
Score = 31.7 bits (70), Expect = 0.70, Method: Composition-based stats.
Identities = 13/58 (22%), Positives = 25/58 (43%)
Query: 345 RAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINP 402
R + L + + +K T+ + G+ E+G+ EVGK D ++ +P
Sbjct: 380 RMKVQRGALAEETGDNDNFRVKRYIAKYTINPALTHGIAHEVGSIEVGKLADLVVWSP 437
>3QGK-C nrPDB
Length = 568
Score = 31.7 bits (70), Expect = 0.75, Method: Composition-based stats.
Identities = 13/50 (26%), Positives = 22/50 (44%)
Query: 353 LLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINP 402
L K + + +K T+ + G+ IG+ E GK D ++ NP
Sbjct: 389 LTEEKGDNDNFRIKRYISKYTINPAITHGVSEYIGSVEEGKIADLVVWNP 438
>4TQT-A nrPDB
Length = 497
Score = 31.4 bits (69), Expect = 0.92, Method: Composition-based stats.
Identities = 33/220 (15%), Positives = 65/220 (29%), Gaps = 49/220 (22%)
Query: 34 LGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQYSFAGS 93
+ + D GKI + ++ + + + + MPG +D H H
Sbjct: 34 ILIED-GKIAAIGDSLE------------GDEVIDASGCYVMPGGIDPHTHLQM------ 74
Query: 94 SIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTACYFATIHTDSSLLL 153
P + ++ + + L GTT F + DS L
Sbjct: 75 ----PFM----------------GTYSSDDFDTGTAAALAGGTTMVVDF--VLPDSEGNL 112
Query: 154 ADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESIKETERFVSEMLQKNYSRVKPIVTPR 213
D ++ Q+A + + + E + E V + K + +
Sbjct: 113 LDALQEWFQKAGKARTDYSFHMAITGWNE---RTFNEMAEVVKRGINT----FKHFMAYK 165
Query: 214 FSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKN 253
+L ++ M H +EN D V ++
Sbjct: 166 GALMVNDDEMFASFQRCAELGAMPLVH-AENGDIVAQLQA 204
Score = 28.7 bits (62), Expect = 5.6, Method: Composition-based stats.
Identities = 10/57 (17%), Positives = 23/57 (40%)
Query: 352 ILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDSP 408
+L V LT E + + ++ L + + G G + D ++ +P+ +
Sbjct: 357 VLWTRGVRTGRLTPNEFVAVTSTNIAKILNIYPQKGAVVPGADADLVIWDPETTKKI 413
>1K1D-A nrPDB
Length = 460
Score = 31.4 bits (69), Expect = 0.93, Method: Composition-based stats.
Identities = 59/441 (13%), Positives = 122/441 (27%), Gaps = 99/441 (22%)
Query: 17 FVHSTWTCPMEVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMP 76
+ + + L + D GKI + + +++ + + P
Sbjct: 4 IIKNGTIVTATDTYEAHLLIKD-GKIAMIGQNLEEKGAE----------VIDAKGCYVFP 52
Query: 77 GLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGT 136
G +D H H ++ + GT
Sbjct: 53 GGIDPHTHLDM--------------------------PLGGTVTKDDFESGTIAAAFGGT 86
Query: 137 TTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESIKETERFVS 196
TT F + L I + GK +D E T++ ++E + +
Sbjct: 87 TTIIDFC-LTNKGEPLKKAIETWHNKAN--GKAVIDYGFHL-MISEITDDVLEELPKVLE 142
Query: 197 EMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKN--- 253
E + + +K + + + + AK + H +EN D ++ +
Sbjct: 143 E---EGITSLKVFMAYKNVFQADDGTLYCTLLAAKELGALVMVH-AENGDVIDYLTKKAL 198
Query: 254 -------LYPSYKNYTSV--------YDKNNLLTNKTVMAHGCYLSA-EELNVFHERGAS 297
+Y + + L ++ + H A E++ +G
Sbjct: 199 ADGNTDPIYHALTRPPELEGEATGRACQLTELAGSQLYVVHVTCAQAVEKIAEARNKGLD 258
Query: 298 I--AHCPN-----------SNLSLSSGFL--NVLEVLKHEVKI---------GLGTDVAG 333
+ CP N + + E EV LG+D
Sbjct: 259 VWGETCPQYLVLDQSYLEKPNFEGAKYVWSPPLREKWHQEVLWNALKNGQLQTLGSDQCS 318
Query: 334 GYSYSMLDAIRRAVM-----------VSNILLINKVNEKSLTLKEVFRLATLGGSQALGL 382
+ R +IL V + +TL + + + ++ GL
Sbjct: 319 FDFKGQKELGRGDFTKIPNGGPIIEDRVSILFSEGVKKGRITLNQFVDIVSTRIAKLFGL 378
Query: 383 DGEIGNFEVGKEFDAILINPK 403
+ G VG + D ++ +P
Sbjct: 379 FPKKGTIVVGSDADLVIFDPN 399
>6HAW-A nrPDB
Length = 438
Score = 31.0 bits (68), Expect = 1.3, Method: Composition-based stats.
Identities = 10/41 (24%), Positives = 15/41 (36%)
Query: 240 HISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHG 280
H+S + A L S++ + Y LL V H
Sbjct: 282 HLSSPLASIAATNKLCQSFQTFNICYADTGLLGAHFVCDHM 322
>3DC8-A nrPDB
Length = 490
Score = 30.6 bits (67), Expect = 1.3, Method: Composition-based stats.
Identities = 60/444 (13%), Positives = 115/444 (25%), Gaps = 96/444 (21%)
Query: 16 TFVHSTWTCPMEVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFM 75
T + ++ + V G+IV + + + + M
Sbjct: 3 TVIKGGTIVTADLTYKADVKVE-GGRIVEIGPNLSGAETLD------------ATGCYVM 49
Query: 76 PGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNG 135
PG +D H H P + ++ + + R L G
Sbjct: 50 PGGIDPHTHLEM----------PFMG----------------TYSSDDFESGTRAALAGG 83
Query: 136 TTTACYFA-TIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESIKETERF 194
TT FA S L + D RA + E E+I + +
Sbjct: 84 TTMVVDFALPSPGQSLLEALTMWDNKSTRANCDYSFHMAITWWGEQVFNEMETIVKDKGI 143
Query: 195 VSEML------------QKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQS--- 239
+ + +S + + + S
Sbjct: 144 NTFKHFMAYKGALMVDDDEMFSSFQRCAALGALPLVHAENGDVVAQLQAKLLAEGNSGPE 203
Query: 240 -HISENRDEVEA----------------VKNLYPSYKNYTSVYDKNNLLTNKTVMAHGC- 281
H EVE V ++ S + + +
Sbjct: 204 AHAYSRPAEVEGEAANRAIMIADMAGCPVYIVHTSCEQAHEAIRRARAKGMRVFGEPLIQ 263
Query: 282 YLSAEELNVFHE----RGASIAHCPNSN--------LSLSSGFLNV-----LEVLKHEVK 324
+L+ +E F + + P N L+SG L V + +
Sbjct: 264 HLTLDETEYFDKDWDHAARRVMSPPFRNKLHQDSLWAGLASGSLQVVATDHCAFTTEQKR 323
Query: 325 IGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDG 384
G+G L+ +L V +T+ E + + ++ L +
Sbjct: 324 FGVGDFTRIPNGTGGLED------RMPMLWTYGVATGRITMNEFVAVTSTNIAKILNIYP 377
Query: 385 EIGNFEVGKEFDAILINPKASDSP 408
+ G VG + D ++ +PK S +
Sbjct: 378 KKGAILVGADADLVVWDPKRSKTI 401
>6N91-A nrPDB
Length = 340
Score = 30.6 bits (67), Expect = 1.5, Method: Composition-based stats.
Identities = 15/104 (14%), Positives = 30/104 (28%), Gaps = 17/104 (16%)
Query: 231 KTRDLHIQSHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNV 290
+ LH+ H E + + + + H + ++
Sbjct: 188 RDAGLHVTVHAGEAAGPESMWQAIRDLGATR---------IGHGVKAIH----DPKLMDY 234
Query: 291 FHERGASIAHCPNSNLSLSS----GFLNVLEVLKHEVKIGLGTD 330
+ I C SNL S+ + L+H + + TD
Sbjct: 235 LAQHRIGIESCLTSNLQTSTVDSLATHPLKRFLEHGILACINTD 278
>3R64-A nrPDB
Length = 508
Score = 30.2 bits (66), Expect = 1.8, Method: Composition-based stats.
Identities = 18/106 (16%), Positives = 37/106 (34%), Gaps = 11/106 (10%)
Query: 295 GASIAHCPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILL 354
G ++ P S+ ++ G + + V G+ + VAG S I + +
Sbjct: 176 GNAVVIKPASDTPVTGGVIPARIFEEAGVPAGVISTVAGAGS-----EIGDHFVTHAVPK 230
Query: 355 INKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILI 400
+ + + V LA GG + E+G +++
Sbjct: 231 LISFTGSTPVGRRVGELAINGG------PMKTVALELGGNAPFVVL 270
>1GKR-A nrPDB
Length = 458
Score = 30.2 bits (66), Expect = 1.9, Method: Composition-based stats.
Identities = 13/61 (21%), Positives = 25/61 (40%), Gaps = 2/61 (3%)
Query: 26 MEVLRDHLLGVSDSGKIVF--LEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHI 83
+V+ + VS G L + + ++ + + +F MPG+VD H+
Sbjct: 2 FDVIVKNCRLVSSDGITEADILVKDGKVAAISADTSDVEASRTIDAGGKFVMPGVVDEHV 61
Query: 84 H 84
H
Sbjct: 62 H 62
>4YHJ-A nrPDB
Length = 584
Score = 29.8 bits (65), Expect = 2.3, Method: Composition-based stats.
Identities = 24/135 (17%), Positives = 46/135 (34%), Gaps = 10/135 (7%)
Query: 181 KETTEESIKETERFVSEMLQKNYSRVKPIVT--PRFSLSCSETLMGELGNIAKTRDLHIQ 238
+E + +TE + + + S + ++T P L C + +D+
Sbjct: 396 EEVDQRIKNDTEEYSEKFSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDI--- 452
Query: 239 SHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASI 298
N +EA P + +VY K+ L + + G YL + + +
Sbjct: 453 -----NFRRLEANMLEPPFCPDPHAVYCKDVLDIEQFSVVKGIYLDTADEDFYARFATGC 507
Query: 299 AHCPNSNLSLSSGFL 313
P N + SG
Sbjct: 508 VSIPWQNEMIESGCF 522
>3CKY-A nrPDB
Length = 301
Score = 29.4 bits (64), Expect = 3.0, Method: Composition-based stats.
Identities = 25/122 (20%), Positives = 45/122 (36%), Gaps = 22/122 (18%)
Query: 286 EELNVFHERGASIAHCPNSNLSLSSGFLNVLEVLKHEVKIGLGTDV-------AGGYSYS 338
+++ + GA A +NL L ++ E L VK GL + + G SY+
Sbjct: 159 KDIYHVGDTGAGDAVKIVNNLLLGCNMASLAEALVLGVKCGLKPETMQEIIGKSSGRSYA 218
Query: 339 MLDAIRRAVMVSNILLINKVNEKSLTLKEVFR-------------LAT--LGGSQALGLD 383
M + + +M + ++ + L +AT G +A+GL
Sbjct: 219 MEAKMEKFIMSGDFAGGFAMDLQHKDLGLALEAGKEGNVPLPMTAMATQIFEGGRAMGLG 278
Query: 384 GE 385
E
Sbjct: 279 RE 280
>1C8N-A nrPDB
Length = 276
Score = 29.4 bits (64), Expect = 3.1, Method: Composition-based stats.
Identities = 13/62 (20%), Positives = 26/62 (41%), Gaps = 2/62 (3%)
Query: 102 WLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTACYFATIHTDSSLLLADITDKFG 161
W+T+ ++ A A T+ + R ++ G + A F T +++ +FG
Sbjct: 26 WVTEASWRAGQAPNKERAA--TVTKSIARKVRGGVSRAGGFVTAPVIGAMVTRPTVPRFG 83
Query: 162 QR 163
R
Sbjct: 84 MR 85
>2VR2-A nrPDB
Length = 541
Score = 29.4 bits (64), Expect = 3.2, Method: Composition-based stats.
Identities = 49/309 (15%), Positives = 90/309 (29%), Gaps = 47/309 (15%)
Query: 60 FKPCEIREL-SHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNID 118
P +R L + + +PG +DTH H Q+ F GS ++ID
Sbjct: 66 GAPAGLRVLDAAGKLVLPGGIDTHTHM-QFPFMGS---------------------RSID 103
Query: 119 FAEEVYTRVVRRTLKNGTTTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFP 178
+ L GTT FA SL+ A T + V +
Sbjct: 104 DFHQGTKAA----LSGGTTMIIDFAIPQKGGSLIEAFETWRSWADPKVCC-------DYS 152
Query: 179 EYKETTEESIKETERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQ 238
+ T S + E + K + K + + ++ + E + K Q
Sbjct: 153 LHVAVTWWSDQVKEEMKILVQDKGVNSFKMFMAYKDLYMVTDLELYEAFSRCKEIGAIAQ 212
Query: 239 SHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASI 298
H +EN D + ++ E + AS
Sbjct: 213 VH-AENGDLIA-------EGAKKMLALGITGPEGHELCRPEAV---EAEATLRAITIASA 261
Query: 299 AHCPNSNLS-LSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDA-IRRAVMVSNILLIN 356
+CP + +S V+ + + K+ G +A + ++ ++
Sbjct: 262 VNCPLYIVHVMSKSAAKVIADARRDGKVVYGEPIAASLGTDGTHYWNKEWHHAAHHVMGP 321
Query: 357 KVNEKSLTL 365
+ T
Sbjct: 322 PLRPDPSTP 330
>1SQH-A nrPDB
Length = 312
Score = 29.4 bits (64), Expect = 3.3, Method: Composition-based stats.
Identities = 12/93 (12%), Positives = 30/93 (32%), Gaps = 11/93 (11%)
Query: 37 SDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQYSFAGSSID 96
SD+G+++ + L E R L A+ +
Sbjct: 217 SDTGELIAWIFQNDFSGLGMLQVLPKAERRGLGGLLA-----------AAMSREIARGEE 265
Query: 97 LPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVR 129
+ L W+ + +E + I + +++ ++
Sbjct: 266 ITLTAWIVATNWRSEALLKRIGYQKDLVNEWIK 298
>5NSQ-A nrPDB
Length = 521
Score = 29.0 bits (63), Expect = 3.9, Method: Composition-based stats.
Identities = 16/86 (18%), Positives = 32/86 (37%), Gaps = 3/86 (3%)
Query: 333 GGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNF--- 389
G + +++ +V + + NE S T V +ATL G+Q +
Sbjct: 361 SGKTVEVINTDAEGRIVLGDGVFHATNELSFTPDVVIDMATLTGAQGIATGRHHAGLYVN 420
Query: 390 EVGKEFDAILINPKASDSPIDLFYGD 415
E G E + ++ ++ + Y
Sbjct: 421 EEGAEAAMLRAGRESGETCFPVLYCP 446
>3GIQ-A nrPDB
Length = 480
Score = 29.0 bits (63), Expect = 4.0, Method: Composition-based stats.
Identities = 42/227 (18%), Positives = 60/227 (26%), Gaps = 35/227 (15%)
Query: 34 LGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQYSFAGS 93
LGV D G+I + E + + PG +D H H
Sbjct: 29 LGVRD-GRIAAIGELGAHPARHAW----------DASGKIVAPGFIDVHGHDDLMFV--- 74
Query: 94 SIDLPLLEWLTK----YTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTACYFATIHTDS 149
+ P L W T T L FA +
Sbjct: 75 --EKPDLRWKTSQGITTVVVGNCGVSAAPAPLPGNTAAALALLGE----TPLFADVPAYF 128
Query: 150 SLLLADITDKFGQRAFVGKVCMDLND-TFPEYKETTEESIKETERFVSEMLQKNYSRVKP 208
+ L A A VG + L P+ T E ++ + +MLQ
Sbjct: 129 AALDAQ-RPMINVAALVGHANLRLAAMRDPQAAPTAAE-----QQAMQDMLQAALEAGAV 182
Query: 209 IVTPRFSLSCSETL----MGELGNIAKTRDLHIQSHISENRDEVEAV 251
+ + + L +A R SHI D VEA
Sbjct: 183 GFSTGLAYQPGAVAQAAELEGLARVAAERRRLHTSHIRNEADGVEAA 229
>6D8G-A nrPDB
Length = 886
Score = 29.0 bits (63), Expect = 4.2, Method: Composition-based stats.
Identities = 15/81 (18%), Positives = 29/81 (35%), Gaps = 3/81 (3%)
Query: 113 RFQNIDFAEEVYTRVVRRTLKNGTTTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMD 172
+ E++ R + G D+ L ++ DK G A+ +D
Sbjct: 333 KPIGPALTAEMHRRDFLLMKEMGANFIRISHYPQADA---LLEMCDKLGMLAWEEIPIID 389
Query: 173 LNDTFPEYKETTEESIKETER 193
+ P Y + E +++E R
Sbjct: 390 IVPNTPGYGDNCERNLREMIR 410
>4OJZ-A nrPDB
Length = 736
Score = 28.7 bits (62), Expect = 5.2, Method: Composition-based stats.
Identities = 16/68 (23%), Positives = 28/68 (41%)
Query: 314 NVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLAT 373
N+ + V + + D GGY++ +A+ + L +EK LT + LA
Sbjct: 63 NLDAFMAEGVVVPMPKDAGGGYTHEQHKRNYKAIRNAGFLYQVTGDEKYLTFAKDLLLAY 122
Query: 374 LGGSQALG 381
+LG
Sbjct: 123 AKMYPSLG 130
>1BEV-3 nrPDB
Length = 242
Score = 28.7 bits (62), Expect = 6.0, Method: Composition-based stats.
Identities = 28/179 (15%), Positives = 54/179 (30%), Gaps = 7/179 (3%)
Query: 46 EEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTK 105
S Q E C E F+PG V+ + +Q + + +E + +
Sbjct: 7 GPGSYQFMTTDEDCSPCILPDFQPTPEIFIPGKVNNLLEIAQVESILEANNREGVEGVER 66
Query: 106 YTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTACYFATIHTDSSLLLADITDK---FGQ 162
Y P + D + + +G ++ T+ + + G
Sbjct: 67 YVIPVSVQ----DALDAQIYALRLELGGSGPLSSSLLGTLAKHYTQWSGSVEITCMFTGT 122
Query: 163 RAFVGKVCMDLNDTFPEYKETTEESIKETERFVSEMLQKNYSRVKPIVTPRFSLSCSET 221
GKV + + EE++ T LQ + + V P ++ S
Sbjct: 123 FMTTGKVLLAYTPPGGDMPRNREEAMLGTHVIWDFGLQSSITLVIPWISASHFRGVSND 181
>5YZA-A nrPDB
Length = 525
Score = 28.3 bits (61), Expect = 7.0, Method: Composition-based stats.
Identities = 7/57 (12%), Positives = 21/57 (36%)
Query: 352 ILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDSP 408
++ V + + + + ++ L G VG + D ++ +P + +
Sbjct: 364 VIWDKAVVTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTI 420
>4NML-A nrPDB
Length = 275
Score = 28.3 bits (61), Expect = 7.8, Method: Composition-based stats.
Identities = 14/82 (17%), Positives = 30/82 (36%), Gaps = 2/82 (2%)
Query: 301 CPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNE 360
P + G+ V ++ +K+GLGT + + + + ++L +
Sbjct: 2 NPQDKAKQAVGYFAVDTYVRSGMKVGLGTGTTAKFVVERIGQRMQEGSLKDLLCVPTSEA 61
Query: 361 KSLTLKEV-FRLATLGG-SQAL 380
+ + L TL G + L
Sbjct: 62 TRKQAESLGIPLTTLDGIADCL 83
Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta
Posted date: Jan 3, 2023 9:05 PM
Number of letters in database: 10,336,785
Number of sequences in database: 36,641
Lambda K H
0.311 0.119 0.295
Lambda K H
0.267 0.0362 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,357,205
Number of Sequences: 36641
Number of extensions: 501498
Number of successful extensions: 1861
Number of sequences better than 10.0: 87
Number of HSP's better than 10.0 without gapping: 75
Number of HSP's successfully gapped in prelim test: 43
Number of HSP's that attempted gapping in prelim test: 1609
Number of HSP's gapped (non-prelim): 161
length of query: 454
length of database: 10,336,785
effective HSP length: 100
effective length of query: 354
effective length of database: 6,672,685
effective search space: 2362130490
effective search space used: 2362130490
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.5 bits)
S2: 60 (27.9 bits)