BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q9XSM3 (730 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 6DMR-A nrPDB 1518 0.0 6BOA-A nrPDB 1069 0.0 6E2G-A nrPDB 1069 0.0 2RFA-A nrPDB 361 e-100 6BBJ-A nrPDB 267 1e-71 6C8G-A nrPDB 267 1e-71 5IRX-A nrPDB 233 2e-61 6DVZ-A nrPDB 230 2e-60 6MHW-A nrPDB 223 2e-58 5AN8-A nrPDB 196 4e-50 5HI9-A nrPDB 182 5e-46 6BO5-A nrPDB 182 5e-46 6OO7-A nrPDB 159 6e-39 2ETB-A nrPDB 109 5e-24 2NYJ-A nrPDB 103 2e-22 2F37-A nrPDB 100 2e-21 4DX2-A nrPDB 100 3e-21 3W9G-A nrPDB 100 3e-21 4N5Q-A nrPDB 95 1e-19 5OEO-C nrPDB 88 1e-17 5MIO-C nrPDB 74 2e-13 6MWQ-A nrPDB 70 2e-12 5H76-A nrPDB 64 2e-10 6FES-A nrPDB 63 4e-10 5AQA-A nrPDB 60 3e-09 5AQB-A nrPDB 59 6e-09 5AQ7-A nrPDB 59 9e-09 5AQ9-A nrPDB 53 6e-07 6AUN-A nrPDB 51 2e-06 4Z68-A nrPDB 50 4e-06 5CBO-A nrPDB 48 1e-05 5GP7-A nrPDB 45 1e-04 4OAU-C nrPDB 44 3e-04 6G1K-A nrPDB 43 4e-04 5Z96-A nrPDB 43 5e-04 3B7B-A nrPDB 42 0.001 4OT9-A nrPDB 41 0.002 6BY9-A nrPDB 39 0.008 5HKP-A nrPDB 39 0.008 4NIK-A nrPDB 39 0.009 1BLX-B nrPDB 38 0.015 4O1O-A nrPDB 38 0.015 3EU9-A nrPDB 38 0.016 5JHQ-A nrPDB 38 0.018 5ET1-A nrPDB 36 0.049 1WG0-A nrPDB 36 0.051 5DND-A nrPDB 35 0.14 2KXP-C nrPDB 35 0.15 6CUD-A nrPDB 35 0.17 2DWZ-A nrPDB 35 0.17 1BD8-A nrPDB 34 0.20 6BWF-A nrPDB 34 0.20 3ZKJ-A nrPDB 34 0.26 6CV9-A nrPDB 33 0.33 3EHQ-A nrPDB 33 0.34 3DEO-A nrPDB 33 0.52 3UI2-A nrPDB 33 0.61 5MKE-A nrPDB 32 0.91 5UQE-A nrPDB 32 0.93 1G3N-B nrPDB 32 1.1 5U0J-A nrPDB 32 1.2 1DCQ-A nrPDB 31 2.0 6BPQ-A nrPDB 31 2.3 6DU8-A nrPDB 31 2.4 3CO4-A nrPDB 30 2.6 6EMK-G nrPDB 30 2.7 5U0K-A nrPDB 30 2.8 4BSZ-B nrPDB 30 3.7 5UIL-A nrPDB 30 3.9 6D1W-A nrPDB 30 3.9 6AYG-A nrPDB 30 4.2 3T9K-A nrPDB 29 6.8 5T4D-A nrPDB 29 7.3 5D68-A nrPDB 29 7.4 >6DMR-A nrPDB Length = 730 Score = 1518 bits (3931), Expect = 0.0, Method: Compositional matrix adjust. Identities = 730/730 (100%), Positives = 730/730 (100%) Query: 1 MGACPPKAKGPWAQLQKLLISWPVGEQDWEQYRDRVNMLQQERIRDSPLLQAAKENDLRL 60 MGACPPKAKGPWAQLQKLLISWPVGEQDWEQYRDRVNMLQQERIRDSPLLQAAKENDLRL Sbjct: 1 MGACPPKAKGPWAQLQKLLISWPVGEQDWEQYRDRVNMLQQERIRDSPLLQAAKENDLRL 60 Query: 61 LKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELAKEPALCEPFVGQTA 120 LKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELAKEPALCEPFVGQTA Sbjct: 61 LKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELAKEPALCEPFVGQTA 120 Query: 121 LHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVR 180 LHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVR Sbjct: 121 LHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVR 180 Query: 181 LLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHSDHLQSLELVPNHQG 240 LLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHSDHLQSLELVPNHQG Sbjct: 181 LLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHSDHLQSLELVPNHQG 240 Query: 241 LTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLTSTLYDLTEIDSWGEELSFLELVVSSK 300 LTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLTSTLYDLTEIDSWGEELSFLELVVSSK Sbjct: 241 LTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLTSTLYDLTEIDSWGEELSFLELVVSSK 300 Query: 301 KREARQILEQTPVKELVSFKWKKYGRPYFCVLASLYILYMICFTTCCIYRPLKLRDDNRT 360 KREARQILEQTPVKELVSFKWKKYGRPYFCVLASLYILYMICFTTCCIYRPLKLRDDNRT Sbjct: 301 KREARQILEQTPVKELVSFKWKKYGRPYFCVLASLYILYMICFTTCCIYRPLKLRDDNRT 360 Query: 361 DPRDITILQQKLLQEAYVTHQDNIRLVGELVTVTGAVIILLLEIPDIFRVGASRYFGQTI 420 DPRDITILQQKLLQEAYVTHQDNIRLVGELVTVTGAVIILLLEIPDIFRVGASRYFGQTI Sbjct: 361 DPRDITILQQKLLQEAYVTHQDNIRLVGELVTVTGAVIILLLEIPDIFRVGASRYFGQTI 420 Query: 421 LGGPFHVIIITYASLVLLTMVMRLTNMNGEVVPLSFALVLGWCSVMYFARGFQMLGPFTI 480 LGGPFHVIIITYASLVLLTMVMRLTNMNGEVVPLSFALVLGWCSVMYFARGFQMLGPFTI Sbjct: 421 LGGPFHVIIITYASLVLLTMVMRLTNMNGEVVPLSFALVLGWCSVMYFARGFQMLGPFTI 480 Query: 481 MIQKMIFGDLMRFCWLMAVVILGFASAFHITFQTEDPNNLGEFSDYPTALFSTFELFLTI 540 MIQKMIFGDLMRFCWLMAVVILGFASAFHITFQTEDPNNLGEFSDYPTALFSTFELFLTI Sbjct: 481 MIQKMIFGDLMRFCWLMAVVILGFASAFHITFQTEDPNNLGEFSDYPTALFSTFELFLTI 540 Query: 541 IDGPANYSVDLPFMYCITYAAFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVAT 600 IDGPANYSVDLPFMYCITYAAFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVAT Sbjct: 541 IDGPANYSVDLPFMYCITYAAFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVAT 600 Query: 601 TVMLERKMPRFLWPRSGICGYEYGLGDRWFLRVENHHDQNPLRVLRYVEAFKCSDKEDGQ 660 TVMLERKMPRFLWPRSGICGYEYGLGDRWFLRVENHHDQNPLRVLRYVEAFKCSDKEDGQ Sbjct: 601 TVMLERKMPRFLWPRSGICGYEYGLGDRWFLRVENHHDQNPLRVLRYVEAFKCSDKEDGQ 660 Query: 661 EQLSEKRPSTVESGMLSRASVAFQTPSLSRTTSQSSNSHRGWEILRRNTLGHLNLGLDLG 720 EQLSEKRPSTVESGMLSRASVAFQTPSLSRTTSQSSNSHRGWEILRRNTLGHLNLGLDLG Sbjct: 661 EQLSEKRPSTVESGMLSRASVAFQTPSLSRTTSQSSNSHRGWEILRRNTLGHLNLGLDLG 720 Query: 721 EGDGEEVYHF 730 EGDGEEVYHF Sbjct: 721 EGDGEEVYHF 730 >6BOA-A nrPDB Length = 742 Score = 1069 bits (2764), Expect = 0.0, Method: Compositional matrix adjust. Identities = 538/727 (74%), Positives = 602/727 (82%), Gaps = 12/727 (1%) Query: 1 MGACPPKAKGPWAQLQKLLISWPVGEQDWEQYRDRVNMLQQERIRDSPLLQAAKENDLRL 60 MG PK KG L W + W Q RD N+LQQ+RI +SPLL AAK+ND++ Sbjct: 1 MGLSLPKEKGLILCLWSKFCRWFQRRESWAQSRDEQNLLQQKRIWESPLLLAAKDNDVQA 60 Query: 61 LKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELAKEPALCEPFVGQTA 120 L LL + C QRGA+GETALH+AALYDNLEAA +LMEAAPEL EP E + GQTA Sbjct: 61 LNKLLKYEDCKVHQRGAMGETALHIAALYDNLEAAMVLMEAAPELVFEPMTSELYEGQTA 120 Query: 121 LHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVR 180 LHIAV+NQN+NLVRALLAR ASVSARATG AFRRSP NLIY+GEHPLSFAACV SEEIVR Sbjct: 121 LHIAVVNQNMNLVRALLARRASVSARATGTAFRRSPCNLIYFGEHPLSFAACVNSEEIVR 180 Query: 181 LLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHSDHLQSLELVPNHQG 240 LLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYD H DHLQ L+LVPNHQG Sbjct: 181 LLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDRHGDHLQPLDLVPNHQG 240 Query: 241 LTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLTSTLYDLTEIDSWGEELSFLELVVSSK 300 LTPFKLAGVEGNTVMFQHLMQKRKH QWT GPLTSTLYDLTEIDS G+E S LEL++++K Sbjct: 241 LTPFKLAGVEGNTVMFQHLMQKRKHTQWTYGPLTSTLYDLTEIDSSGDEQSLLELIITTK 300 Query: 301 KREARQILEQTPVKELVSFKWKKYGRPYFCVLASLYILYMICFTTCCIYRPLKLRDDNRT 360 KREARQIL+QTPVKELVS KWK+YGRPYFC+L ++Y+LY+ICFT CCIYRPLK R +NRT Sbjct: 301 KREARQILDQTPVKELVSLKWKRYGRPYFCMLGAIYLLYIICFTMCCIYRPLKPRTNNRT 360 Query: 361 DPRDITILQQKLLQEAYVTHQDNIRLVGELVTVTGAVIILLLEIPDIFRVGASRYFGQTI 420 PRD T+LQQKLLQEAY+T +D+IRLVGELVTV GA+IILL+E+PDIFR+G +R+FGQTI Sbjct: 361 SPRDNTLLQQKLLQEAYMTPKDDIRLVGELVTVIGAIIILLVEVPDIFRMGVTRFFGQTI 420 Query: 421 LGGPFHVIIITYASLVLLTMVMRLTNMNGEVVPLSFALVLGWCSVMYFARGFQMLGPFTI 480 LGGPFHV+IITYA +VL+TMVMRL + +GEVVP+SFALVLGWC+VMYFA GFQMLGPFTI Sbjct: 421 LGGPFHVLIITYAFMVLVTMVMRLISASGEVVPMSFALVLGWCNVMYFAEGFQMLGPFTI 480 Query: 481 MIQKMIFGDLMRFCWLMAVVILGFASAFHITFQTEDPNNLGEFSDYPTALFSTFELFLTI 540 MIQKMIFGDLMRFCWLMAVVILGFASAF+I FQTEDP LG F DYP ALFSTFELFLTI Sbjct: 481 MIQKMIFGDLMRFCWLMAVVILGFASAFYIIFQTEDPEELGHFYDYPMALFSTFELFLTI 540 Query: 541 IDGPANYSVDLPFMYCITYAAFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVAT 600 IDGPANY+VDLPFMY ITYAAFAIIATLLMLNL IAMMGDTHWRVA ERDELWRAQ+VAT Sbjct: 541 IDGPANYNVDLPFMYSITYAAFAIIATLLMLNLLIAMMGDTHWRVAHERDELWRAQIVAT 600 Query: 601 TVMLERKMPRFLWPRSGICGYEYGLGDRWFLRVENHHDQNPLRVLRYVEAFKCSDKEDGQ 660 TVMLERK+PR LWPRSGICG EYGLGDRWFLRVE+ D N R+ RY +AF ED Sbjct: 601 TVMLERKLPRCLWPRSGICGREYGLGDRWFLRVEDRQDLNRQRIQRYAQAFHTRGSEDLD 660 Query: 661 EQLSEKRPSTVESGMLSRASVAFQTPSLSRTTSQSSNSHRGWEILRRNTL-----GHLNL 715 + EK +E G ++ PS+SR+TS+SS + WE LR+ TL G +N Sbjct: 661 KDSVEK----LELGCPFSPHLSLPMPSVSRSTSRSSAN---WERLRQGTLRRDLRGIINR 713 Query: 716 GLDLGEG 722 GL+ GE Sbjct: 714 GLEDGES 720 >6E2G-A nrPDB Length = 727 Score = 1069 bits (2764), Expect = 0.0, Method: Compositional matrix adjust. Identities = 541/734 (73%), Positives = 610/734 (83%), Gaps = 24/734 (3%) Query: 1 MGACPPKAKGPWAQLQKLLISWPVGEQDWEQYRDRVNMLQQERIRDSPLLQAAKENDLRL 60 MG PK KG L W + W Q RD N+LQQ+RI +SPLL AAKEN+++ Sbjct: 1 MGWSLPKEKGLILCLWNKFCRWFHRRESWAQSRDEQNLLQQKRIWESPLLLAAKENNVQA 60 Query: 61 LKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELAKEPALCEPFVGQTA 120 L LL + C+ Q+GA+GETALH+AALYDNLEAA +LMEAAPEL EP E + GQTA Sbjct: 61 LIKLLKFEGCEVHQKGAMGETALHIAALYDNLEAAMVLMEAAPELVFEPMTSELYEGQTA 120 Query: 121 LHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVR 180 LHIAV+NQN+NLVRALLARGASVSARATG+ F PHNLIYYGEHPLSFAACVGSEEIVR Sbjct: 121 LHIAVINQNVNLVRALLARGASVSARATGSVFHYRPHNLIYYGEHPLSFAACVGSEEIVR 180 Query: 181 LLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHSDHLQSLELVPNHQG 240 LLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYD DHL+SLELVPN+QG Sbjct: 181 LLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYD-GGDHLKSLELVPNNQG 239 Query: 241 LTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLTSTLYDLTEIDSWGEELSFLELVVSSK 300 LTPFKLAGVEGN VMFQHLMQKRKH+QWT GPLTSTLYDLTEIDS G++ S LEL+V++K Sbjct: 240 LTPFKLAGVEGNIVMFQHLMQKRKHIQWTYGPLTSTLYDLTEIDSSGDDQSLLELIVTTK 299 Query: 301 KREARQILEQTPVKELVSFKWKKYGRPYFCVLASLYILYMICFTTCCIYRPLKLRDDNRT 360 KREARQIL+QTPVKELVS KWK+YGRPYFCVL ++Y+LY+ICFT CC+YRPLK R NRT Sbjct: 300 KREARQILDQTPVKELVSLKWKRYGRPYFCVLGAIYVLYIICFTMCCVYRPLKPRITNRT 359 Query: 361 DPRDITILQQKLLQEAYVTHQDNIRLVGELVTVTGAVIILLLEIPDIFRVGASRYFGQTI 420 +PRD T+LQQKLLQEAYVT +D++RLVGELV++ GAVIILL+EIPDIFR+G +R+FGQTI Sbjct: 360 NPRDNTLLQQKLLQEAYVTPKDDLRLVGELVSIVGAVIILLVEIPDIFRLGVTRFFGQTI 419 Query: 421 LGGPFHVIIITYASLVLLTMVMRLTNMNGEVVPLSFALVLGWCSVMYFARGFQMLGPFTI 480 LGGPFHVII+TYA +VL+TMVMRLTN +GEVVP+SFALVLGWC+VMYFARGFQMLGPFTI Sbjct: 420 LGGPFHVIIVTYAFMVLVTMVMRLTNSDGEVVPMSFALVLGWCNVMYFARGFQMLGPFTI 479 Query: 481 MIQKMIFGDLMRFCWLMAVVILGFASAFHITFQTEDPNNLGEFSDYPTALFSTFELFLTI 540 MIQKMIFGDLMRFCWLMAVVILGFASAF+I FQTEDP+ LG F DYP ALFSTFELFLTI Sbjct: 480 MIQKMIFGDLMRFCWLMAVVILGFASAFYIIFQTEDPDELGHFYDYPMALFSTFELFLTI 539 Query: 541 IDGPANYSVDLPFMYCITYAAFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVAT 600 IDGPANY VDLPFMY ITYAAFAIIATLLMLNL IAMMGDTHWRVA ERDELWRAQVVAT Sbjct: 540 IDGPANYDVDLPFMYSITYAAFAIIATLLMLNLLIAMMGDTHWRVAHERDELWRAQVVAT 599 Query: 601 TVMLERKMPRFLWPRSGICGYEYGLGDRWFLRVENHHDQNPLRVLRYVEAFKCSD----- 655 TVMLERK+PR LWPRSGICG EYGLGDRWFLRVE+ D N R+ RY +AF+ D Sbjct: 600 TVMLERKLPRCLWPRSGICGREYGLGDRWFLRVEDRQDLNRQRIRRYAQAFQQQDDLYSE 659 Query: 656 --KEDGQEQLSEKRPSTVESGMLSRASVAFQTPSLSRTTSQSSNSHRGWEILRRNTL--- 710 ++D E+L RP A ++F TPS+SR+TS+SS + W+ LR+ L Sbjct: 660 DLEKDSGEKLEMARPFG--------AYLSFPTPSVSRSTSRSSTN---WDRLRQGALRKD 708 Query: 711 --GHLNLGLDLGEG 722 G +N GL+ GEG Sbjct: 709 LQGIINRGLEDGEG 722 >2RFA-A nrPDB Length = 232 Score = 361 bits (926), Expect = e-100, Method: Compositional matrix adjust. Identities = 181/221 (81%), Positives = 195/221 (88%), Gaps = 1/221 (0%) Query: 44 IRDSPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAP 103 I +SPLL AAKEND++ L LL + C+ QRGA+GETALH+AALYDNLEAA +LMEAAP Sbjct: 2 IWESPLLLAAKENDVQALSKLLKFEGCEVHQRGAMGETALHIAALYDNLEAAMVLMEAAP 61 Query: 104 ELAKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYG 163 EL EP E + GQTALHIAV+NQN+NLVRALLARGASVSARATG+ F PHNLIYYG Sbjct: 62 ELVFEPMTSELYEGQTALHIAVINQNVNLVRALLARGASVSARATGSVFHYRPHNLIYYG 121 Query: 164 EHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYD 223 EHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYD Sbjct: 122 EHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYD 181 Query: 224 EHSDHLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQKRK 264 DHL+SLELVPN+QGLTPFKLAGVEGN VMFQHLMQKRK Sbjct: 182 G-GDHLKSLELVPNNQGLTPFKLAGVEGNIVMFQHLMQKRK 221 >6BBJ-A nrPDB Length = 868 Score = 267 bits (683), Expect = 1e-71, Method: Compositional matrix adjust. Identities = 186/577 (32%), Positives = 293/577 (50%), Gaps = 72/577 (12%) Query: 115 FVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFR-RSPHNLIYYGEHPLSFAACV 173 + GQTALHIA+ + + V L+ +GA V A+A G F+ + Y+GE PLS AAC Sbjct: 232 YRGQTALHIAIERRCKHYVELLVEKGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACT 291 Query: 174 GSEEIVRLLIEHG---ADIRAQDSLGNTVLHILI-----LQPNKTFACQMYNLLLSYDEH 225 +IV L E+ ADIR QDS GNTVLH L+ + N F ++Y+LL+ Sbjct: 292 NQPDIVHYLTENAHKKADIRRQDSRGNTVLHALVAIADNTRENTKFVTKVYDLLVIKCVK 351 Query: 226 SDHLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQ-----------KRKHVQWTCGPLT 274 SLE + N+ ++P +A G +FQH+++ RK W GP+ Sbjct: 352 LYPDSSLEAIFNNDSMSPLMMAAKLGKIGIFQHIIRLEIKDEEARHLSRKFRDWAYGPVY 411 Query: 275 STLYDLTEIDSWGEELSFLELVVSSKKREAR-QILEQTPVKELVSFKWKKYGRPYFCVLA 333 S+LYDL+ +D+ GEE+S LE++V + K E R ++L P+ EL+ KW+K+G F + Sbjct: 412 SSLYDLSMLDTCGEEVSVLEILVYNSKVENRHEMLAVEPINELLRDKWQKFGAVSFYISV 471 Query: 334 SLYILYMICFTTCCIYRPLKLRDDNRTDPRDITILQQKLLQEAYVTHQDNIRLVGELVTV 393 Y++ MI FT YRP+ + T P Y T D +RL GE+VT+ Sbjct: 472 VSYLIAMIIFTLIAYYRPM-----DGTPPY------------PYRTTMDYMRLAGEIVTL 514 Query: 394 TGAVIILLLEIPDIFRV---GASRYFGQTILGGPFHVIIITYASLVLLTMVMRLTNMNGE 450 V+ + I D+F G + F + G F ++ Y+ LV++T V+ L + Sbjct: 515 LTGVVFFITNIKDLFMKKCPGVNSLF----IDGSFQLLYFIYSVLVIITAVLYLVGIESY 570 Query: 451 VVPLSFALVLGWCSVMYFARGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAF-- 508 + + FALVLGW + +YF RG ++ G ++IM+QK++F DL RF + + ++G+ASA Sbjct: 571 LAVMVFALVLGWMNALYFTRGLKLTGTYSIMLQKILFKDLFRFLLVYLLFMIGYASALVS 630 Query: 509 --------HITFQTEDPNNLGEF------SDYPTALFSTFELFLTIIDGPANYSVDLPFM 554 +T + E+ S + L F+L + + D S P + Sbjct: 631 LLNPCTSQESCIETSSNCTVPEYPSCRDSSTFSKFLLDLFKLTIGMGDLEMINSAKYPAV 690 Query: 555 YCITYAAFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVATTVMLERKMPRFLWP 614 + I + I+ +L+LN+ IA+MG+T +V++E ++W+ Q T + +ER P + Sbjct: 691 FIILLVTYIILTFVLLLNMLIALMGETVGQVSKESKQIWKLQWATTILDIERSFPVCMRK 750 Query: 615 --RSG----ICGYEYGLGD-RWFLRVE----NHHDQN 640 RSG + G D RW RV+ +H +QN Sbjct: 751 AFRSGEMVTVGKNLDGTPDRRWCFRVDEVNWSHWNQN 787 >6C8G-A nrPDB Length = 675 Score = 267 bits (682), Expect = 1e-71, Method: Compositional matrix adjust. Identities = 186/575 (32%), Positives = 292/575 (50%), Gaps = 72/575 (12%) Query: 117 GQTALHIAVMNQNLNLVRALLARGASVSARATGAAFR-RSPHNLIYYGEHPLSFAACVGS 175 GQTALHIA+ + + V L+ +GA V A+A G F+ + Y+GE PLS AAC Sbjct: 103 GQTALHIAIERRCKHYVELLVEKGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTNQ 162 Query: 176 EEIVRLLIEHG---ADIRAQDSLGNTVLHILI-----LQPNKTFACQMYNLLLSYDEHSD 227 +IV L E+ ADIR QDS GNTVLH L+ + N F ++Y+LL+ Sbjct: 163 PDIVHYLTENAHKKADIRRQDSRGNTVLHALVAIADNTRENTKFVTKVYDLLVIKCVKLY 222 Query: 228 HLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQ-----------KRKHVQWTCGPLTST 276 SLE + N+ ++P +A G +FQH+++ RK W GP+ S+ Sbjct: 223 PDSSLEAIFNNDSMSPLMMAAKLGKIGIFQHIIRLEIKDEEARHLSRKFRDWAYGPVYSS 282 Query: 277 LYDLTEIDSWGEELSFLELVVSSKKREAR-QILEQTPVKELVSFKWKKYGRPYFCVLASL 335 LYDL+ +D+ GEE+S LE++V + K E R ++L P+ EL+ KW+K+G F + Sbjct: 283 LYDLSMLDTCGEEVSVLEILVYNSKVENRHEMLAVEPINELLRDKWQKFGAVSFYISVVS 342 Query: 336 YILYMICFTTCCIYRPLKLRDDNRTDPRDITILQQKLLQEAYVTHQDNIRLVGELVTVTG 395 Y++ MI FT YRP+ + T P Y T D +RL GE+VT+ Sbjct: 343 YLIAMIIFTLIAYYRPM-----DGTPPY------------PYRTTMDYMRLAGEIVTLLT 385 Query: 396 AVIILLLEIPDIFRV---GASRYFGQTILGGPFHVIIITYASLVLLTMVMRLTNMNGEVV 452 V+ + I D+F G + F + G F ++ Y+ LV++T V+ L + + Sbjct: 386 GVVFFITNIKDLFMKKCPGVNSLF----IDGSFQLLYFIYSVLVIITAVLYLVGIESYLA 441 Query: 453 PLSFALVLGWCSVMYFARGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAF---- 508 + FALVLGW + +YF RG ++ G ++IM+QK++F DL RF + + ++G+ASA Sbjct: 442 VMVFALVLGWMNALYFTRGLKLTGTYSIMLQKILFKDLFRFLLVYLLFMIGYASALVSLL 501 Query: 509 ------HITFQTEDPNNLGEF------SDYPTALFSTFELFLTIIDGPANYSVDLPFMYC 556 +T + E+ S + L F+L + + D S P ++ Sbjct: 502 NPCTSQESCIETSSQCTVPEYPSCRDSSTFSKFLLDLFKLTIGMGDLEMINSAKYPAVFI 561 Query: 557 ITYAAFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVATTVMLERKMPRFLWP-- 614 I + I+ +L+LN+ IA+MG+T +V++E ++W+ Q T + +ER P + Sbjct: 562 ILLVTYIILTFVLLLNMLIALMGETVGQVSKESKQIWKLQWATTILDIERSFPVCMRKAF 621 Query: 615 RSG----ICGYEYGLGD-RWFLRVE----NHHDQN 640 RSG + G D RW RV+ +H +QN Sbjct: 622 RSGEMVTVGKNLDGTPDRRWCFRVDEVNWSHWNQN 656 >5IRX-A nrPDB Length = 636 Score = 233 bits (594), Expect = 2e-61, Method: Compositional matrix adjust. Identities = 169/556 (30%), Positives = 274/556 (49%), Gaps = 68/556 (12%) Query: 115 FVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNL-IYYGEHPLSFAACV 173 + GQTALHIA+ +N+ LV L+ GA V A A G F+++ Y+GE PLS AAC Sbjct: 94 YKGQTALHIAIERRNMTLVTLLVENGADVQAAANGDFFKKTKGRPGFYFGELPLSLAACT 153 Query: 174 GSEEIVRLLIEHG---ADIRAQDSLGNTVLHILILQPNKT-----FACQMYNLLLSYDEH 225 IV+ L+++ ADI A+DS+GNTVLH L+ + T F MYN +L Sbjct: 154 NQLAIVKFLLQNSWQPADISARDSVGNTVLHALVEVADNTVDNTKFVTSMYNEILILGAK 213 Query: 226 SDHLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQK-----------RKHVQWTCGPLT 274 LE + N +GLTP LA G + +++Q+ RK +W GP+ Sbjct: 214 LHPTLKLEEITNRKGLTPLALAASSGKIGVLAYILQREIHEPECRHLSRKFTEWAYGPVH 273 Query: 275 STLYDLTEIDSWGEELSFLELVV--SSKKREARQILEQTPVKELVSFKWKKYGRPYFCVL 332 S+LYDL+ ID+ E+ S LE++ SS+ +L P+ L+ KW ++ + F Sbjct: 274 SSLYDLSCIDT-CEKNSVLEVIAYSSSETPNRHDMLLVEPLNRLLQDKWDRFVKRIFYFN 332 Query: 333 ASLYILYMICFTTCCIYRPL------KLRDDNRTDPRDITILQQKLLQEAYVTHQDNIRL 386 +Y LYMI FT YRP+ KL++ T D R+ Sbjct: 333 FFVYCLYMIIFTAAAYYRPVEGLPPYKLKN----------------------TVGDYFRV 370 Query: 387 VGELVTVTGAVIILLLEIPDIFRVGASRYFGQTILGGPFHVIIITYASL-VLLTMVMRLT 445 GE+++V+G V I + S +++ + I+ SL +L+++V+ + Sbjct: 371 TGEILSVSGGVYFFFRGIQYFLQRRPSL---KSLFVDSYSEILFFVQSLFMLVSVVLYFS 427 Query: 446 NMNGEVVPLSFALVLGWCSVMYFARGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFA 505 V + F+L +GW +++Y+ RGFQ +G + +MI+KMI DL RF ++ V + GF+ Sbjct: 428 QRKEYVASMVFSLAMGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYLVFLFGFS 487 Query: 506 SAFHITFQTEDPNNLGEFSDYPTALFSTFELFLTIIDGPANYSVDLPFMYCITYAAFAII 565 +A + ED G+++ + F+ + + D + D ++ I A+ I+ Sbjct: 488 TA--VVTLIED----GKYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVFIILLLAYVIL 541 Query: 566 ATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVATTVMLERKMPRFLWP--RSGI---CG 620 +L+LN+ IA+MG+T ++AQE +W+ Q T + E+ + + RSG G Sbjct: 542 TYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKAFRSGKLLQVG 601 Query: 621 YEYGLGD--RWFLRVE 634 + D RW RV+ Sbjct: 602 FTPDGKDDYRWCFRVD 617 Score = 30.8 bits (68), Expect = 2.5, Method: Compositional matrix adjust. Identities = 18/39 (46%), Positives = 21/39 (53%), Gaps = 2/39 (5%) Query: 48 PLLQAAKENDLRLLKILLLN--QSCDFQQRGAVGETALH 84 PL AA N L ++K LL N Q D R +VG T LH Sbjct: 146 PLSLAACTNQLAIVKFLLQNSWQPADISARDSVGNTVLH 184 >6DVZ-A nrPDB Length = 791 Score = 230 bits (586), Expect = 2e-60, Method: Compositional matrix adjust. Identities = 157/526 (29%), Positives = 271/526 (51%), Gaps = 45/526 (8%) Query: 113 EPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFR-RSPHNLIYYGEHPLSFAA 171 E + GQTAL+IA+ + ++ L+A GA V+A A G F + H Y+GE PL+ AA Sbjct: 211 EAYEGQTALNIAIERRQGDITAVLIAAGADVNAHAKGVFFNPKYQHEGFYFGETPLALAA 270 Query: 172 CVGSEEIVRLLIEH-GADIRAQDSLGNTVLHILI-----LQPNKTFACQMYNLLLSYDEH 225 C EIV+LL+E+ DI +QDS GN +LH L+ + F +MY+++L + Sbjct: 271 CTNQPEIVQLLMENEQTDITSQDSRGNNILHALVTVAEDFKTQNDFVKRMYDMILLRSGN 330 Query: 226 SDHLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQK-----------RKHVQWTCGPLT 274 + LE + N+ GLTP +LA G + ++++ + RK W GP++ Sbjct: 331 WE----LETMRNNDGLTPLQLAAKMGKAEILKYILSREIKEKPLRSLSRKFTDWAYGPVS 386 Query: 275 STLYDLTEIDSWGEELSFLELVVSSKKREAR-QILEQTPVKELVSFKWKKYGRPYFCVLA 333 S+LYDLT +D+ + S LE++V + + R ++L P+ L+ KWKK+ + F + Sbjct: 387 SSLYDLTNVDTTTDN-SVLEIIVYNTNIDNRHEMLTLEPLHTLLHTKWKKFAKYMFFLSF 445 Query: 334 SLYILYMICFTTCCIYRPLKLRDDNRTDPRDITILQQKLLQEAYVTHQDN-IRLVGELVT 392 Y Y I T YRP R+D + L +TH+ + ++L+G + Sbjct: 446 CFYFFYNITLTLVSYYRP---RED------------EDLPHPLALTHKMSWLQLLGRMFV 490 Query: 393 VTGAVIILLLEIPDIFRVGASRYFGQTILGGP-FHVIIITYASLVLLTMVMRLTNMNGEV 451 + A I + E IF + S Q+IL FH + A LV+L++ + L + Sbjct: 491 LIWATCISVKEGIAIFLLRPSDL--QSILSDAWFHFVFFVQAVLVILSVFLYLFAYKEYL 548 Query: 452 VPLSFALVLGWCSVMYFARGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFHIT 511 L A+ LGW +++ + RGFQ +G +++MIQK+I D+++F ++ + +LGF A Sbjct: 549 ACLVLAMALGWANMLAYTRGFQSMGMYSVMIQKVILHDVLKFLFVYILFLLGFGVALASL 608 Query: 512 FQ--TEDPNNLGEFSDYPTALFSTFELFLTIIDGPANYSVDLPFMYCITYAAFAIIATLL 569 + ++D + + + A+ F+L + + D + P ++ + I+ +L Sbjct: 609 IEKCSKDKKDCSSYGSFSDAVLELFKLTIGLGDLNIQQNSTYPILFLFLLITYVILTFVL 668 Query: 570 MLNLFIAMMGDTHWRVAQERDELWRAQVVATTVMLERKMPRFLWPR 615 +LN+ IA+MG+T V++E + +WR Q T + E+ +P +L R Sbjct: 669 LLNMLIALMGETVENVSKESERIWRLQRARTILEFEKMLPEWLRSR 714 >6MHW-A nrPDB Length = 826 Score = 223 bits (569), Expect = 2e-58, Method: Compositional matrix adjust. Identities = 161/529 (30%), Positives = 272/529 (51%), Gaps = 51/529 (9%) Query: 113 EPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFR-RSPHNLIYYGEHPLSFAA 171 E + GQTAL+IA+ + ++ L+A GA V+A A GA F + H Y+GE PL+ AA Sbjct: 212 EAYEGQTALNIAIERRQGDIAALLIAAGADVNAHAKGAFFNPKYQHEGFYFGETPLALAA 271 Query: 172 CVGSEEIVRLLIEH-GADIRAQDSLGNTVLHILI-----LQPNKTFACQMYNLLLSYDEH 225 C EIV+LL+EH DI ++DS GN +LH L+ + F +MY+++L + Sbjct: 272 CTNQPEIVQLLMEHEQTDITSRDSRGNNILHALVTVAEDFKTQNDFVKRMYDMILLRSGN 331 Query: 226 SDHLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQK-----------RKHVQWTCGPLT 274 + LE N+ GLTP +LA G + ++++ + RK W GP++ Sbjct: 332 WE----LETTRNNDGLTPLQLAAKMGKAEILKYILSREIKEKRLRSLSRKFTDWAYGPVS 387 Query: 275 STLYDLTEIDSWGEELSFLELVVSSKKREAR-QILEQTPVKELVSFKWKKYGRPYFCVLA 333 S+LYDLT +D+ + S LE+ V + + R ++L P+ L+ KWKK+ + F + Sbjct: 388 SSLYDLTNVDTTTDN-SVLEITVYNTNIDNRHEMLTLEPLHTLLHMKWKKFAKHMFFLSF 446 Query: 334 SLYILYMICFTTCCIYRPLKLRDDNRTDPRDITILQQKLLQEAYVTHQDN-IRLVGELVT 392 Y Y I T YRP + ++ + +TH+ ++L+G + Sbjct: 447 CFYFFYNITLTLVSYYRPRE---------------EEAIPHPLALTHKMGWLQLLGRMFV 491 Query: 393 VTGAVIILLLEIPDIFRVGASRYFGQTILGGP-FHVIIITYASLVLLTMVMRLTNMNGEV 451 + A+ I + E IF + S Q+IL FH + A LV+L++ + L + Sbjct: 492 LIWAMCISVKEGIAIFLLRPSDL--QSILSDAWFHFVFFIQAVLVILSVFLYLFAYKEYL 549 Query: 452 VPLSFALVLGWCSVMYFARGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFHIT 511 L A+ LGW +++Y+ RGFQ +G +++MIQK+I D+++F ++ V +LGF A Sbjct: 550 ACLVLAMALGWANMLYYTRGFQSMGMYSVMIQKVILHDVLKFLFVYIVFLLGFGVALASL 609 Query: 512 FQ-----TEDPNNLGEFSDYPTALFSTFELFLTIIDGPANYSVDLPFMYCITYAAFAIIA 566 + +D ++ G FSD A+ F+L + + D + P ++ + I+ Sbjct: 610 IEKCPKDNKDCSSYGSFSD---AVLELFKLTIGLGDLNIQQNSKYPILFLFLLITYVILT 666 Query: 567 TLLMLNLFIAMMGDTHWRVAQERDELWRAQVVATTVMLERKMPRFLWPR 615 +L+LN+ IA+MG+T V++E + +WR Q T + E+ +P +L R Sbjct: 667 FVLLLNMLIALMGETVENVSKESERIWRLQRARTILEFEKMLPEWLRSR 715 >5AN8-A nrPDB Length = 613 Score = 196 bits (497), Expect = 4e-50, Method: Compositional matrix adjust. Identities = 172/565 (30%), Positives = 286/565 (50%), Gaps = 61/565 (10%) Query: 76 GAVGETALHVAALYDNL-EAATLLMEAAPELAKEPALCEPFV----------GQTALHIA 124 G+ G+T L A L NL + ++ E+ ++ +P V G +ALHIA Sbjct: 37 GSTGKTCLMKAVL--NLQDGVNACIQPLLEIDRDSGNPQPLVNAQCTDEYYRGHSALHIA 94 Query: 125 VMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVRLLIE 184 + ++L V+ L+ GA+V A+A G F+++ Y+GE PLS AAC ++V L+E Sbjct: 95 IEKRSLQCVKLLVENGANVHAKACGHFFQKNQDTCFYFGELPLSLAACTKQWDVVNYLLE 154 Query: 185 H---GADIRAQDSLGNTVLHILIL-----QPNKTFACQMYNLLLSYDEHSDHLQSLELVP 236 + A ++AQDSLGNTVLH L++ N +MY+ LL LE +P Sbjct: 155 NPHPAASLQAQDSLGNTVLHALVMIADNSPENSALVVRMYDGLLQAGARLCPNVQLEGIP 214 Query: 237 NHQGLTPFKLAGVEGNTVMFQHLMQK----------RKHVQWTCGPLTSTLYDLTEIDSW 286 N +GLTP KLA EG +F+H++Q+ RK +W GP+ +LYDL +DSW Sbjct: 215 NLEGLTPLKLAAKEGKIEIFKHILQREFSAPCQSLSRKFTEWCYGPVRVSLYDLASVDSW 274 Query: 287 GEELSFLELVV---SSKKREARQILEQTPVKELVSFKWKKYGRPYFCVLASLYILYMICF 343 EE S LE++ S R +LE P+ +L+ KW + P FC Y++YM+ F Sbjct: 275 -EENSVLEIIAFHSRSPHRHRMVVLE--PLNKLLQAKWDRL-IPRFCFNFLCYLVYMLIF 330 Query: 344 TTCCIYRPLKLRDDNRTDPRDITILQQKLLQEAYVTHQDNIRLVGELVTVTGAVIILLLE 403 T ++P L+++ T +++ L+G ++ + G V +LL + Sbjct: 331 TAVAYHQP---------------ALEKQGFPPLKATAGNSMLLLGHILILLGGVYLLLGQ 375 Query: 404 IPDIFRVGASRYFGQTILGGPFHVIIITYASLVLLTMVMRLTNMNGEVVPLSFALVLGWC 463 + +R + + + F ++ + A L +L+ V+ + + L +LVLGW Sbjct: 376 LWYFWR--RRLFIWISFMDSYFEILFLLQALLTVLSQVLCFLAIEWYLPLLVSSLVLGWL 433 Query: 464 SVMYFARGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFHITFQTEDPNNLGEF 523 +++Y+ RGFQ G +++MIQK+I DL+RF + V + GFA A ++ E + E Sbjct: 434 NLLYYTRGFQHTGIYSVMIQKVILRDLLRFLLVYLVFLFGFAVAL-VSLSREAQED--EA 490 Query: 524 SDYPTALFSTFELF-LTIIDGPANYSVDLPF--MYCITYAAFAIIATLLMLNLFIAMMGD 580 Y + L ++ ELF TI G + L F + + A+ ++ +L+LN+ IA+M + Sbjct: 491 PPYRSILDASLELFKFTIGMGELAFQEQLRFRGVVLLLLLAYVLLTYVLLLNMLIALMSE 550 Query: 581 THWRVAQERDELWRAQVVATTVMLE 605 T VA + +W+ Q + + +E Sbjct: 551 TVNSVATDSWSIWKLQKAISVLEME 575 >5HI9-A nrPDB Length = 770 Score = 182 bits (462), Expect = 5e-46, Method: Compositional matrix adjust. Identities = 173/580 (29%), Positives = 282/580 (48%), Gaps = 71/580 (12%) Query: 76 GAVGETALHVAAL--YDNLEAATLLMEAAPELAKEP-----ALC--EPFVGQTALHIAVM 126 G+ G+T L A L D + A + + + + P A C E + G +ALHIA+ Sbjct: 114 GSTGKTCLMKAVLNLQDGVNACIMPLLQIDKDSGNPKPLVNAQCTDEFYQGHSALHIAIE 173 Query: 127 NQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVRLLIEHG 186 ++L V+ L+ GA V RA G F++ Y+GE PLS AAC ++V L+E+ Sbjct: 174 KRSLQCVKLLVENGADVHLRACGRFFQKHQGTCFYFGELPLSLAACTKQWDVVTYLLENP 233 Query: 187 ---ADIRAQDSLGNTVLHILIL-----QPNKTFACQMYNLLLSYDEHSDHLQSLELVPNH 238 A + A DSLGNTVLH L++ N MY+ LL LE + NH Sbjct: 234 HQPASLEATDSLGNTVLHALVMIADNSPENSALVIHMYDGLLQMGARLCPTVQLEEISNH 293 Query: 239 QGLTPFKLAGVEGNTVMFQHLMQK----------RKHVQWTCGPLTSTLYDLTEIDSWGE 288 QGLTP KLA EG +F+H++Q+ RK +W GP+ +LYDL+ +DSW E Sbjct: 294 QGLTPLKLAAKEGKIEIFRHILQREFSGPYQPLSRKFTEWCYGPVRVSLYDLSSVDSW-E 352 Query: 289 ELSFLELVV---SSKKREARQILEQTPVKELVSFKWKKYGRPYFCVLASLYILYMICFTT 345 + S LE++ S R +LE P+ +L+ KW + +F A Y++YM FT Sbjct: 353 KNSVLEIIAFHCKSPNRHRMVVLE--PLNKLLQEKWDRLVSRFFFNFAC-YLVYMFIFTV 409 Query: 346 CCIYRPLKLRDDNRTDPRDITILQQKLLQEAYVTHQDNIRLVGELVTVTGAVIILLLEIP 405 ++P L Q + + T +++ L+G ++ + G + +LL ++ Sbjct: 410 VAYHQP---------------SLDQPAIPSSKATFGESMLLLGHILILLGGIYLLLGQLW 454 Query: 406 DIFRVGASRYFGQTILGGPFHVIIITYASLVLLTMVMRLTNMNGEVVPLSFALVLGWCSV 465 +R + + + F ++ + A L +L+ V+R + L +LVLGW ++ Sbjct: 455 YFWR--RRLFIWISFMDSYFEILFLLQALLTVLSQVLRFMETEWYLPLLVLSLVLGWLNL 512 Query: 466 MYFARGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAF-HITFQTEDP----NNL 520 +Y+ RGFQ G +++MIQK+I DL+RF + V + GFA A ++ + P +N Sbjct: 513 LYYTRGFQHTGIYSVMIQKVILRDLLRFLLVYLVFLFGFAVALVSLSREARSPKAPEDNN 572 Query: 521 GEFSDYPTA------------LFSTFELF-LTIIDGPANYSVDLPF--MYCITYAAFAII 565 ++ PT L ++ ELF TI G + L F + + A+ ++ Sbjct: 573 STVTEQPTVGQEEEPAPYRSILDASLELFKFTIGMGELAFQEQLRFRGVVLLLLLAYVLL 632 Query: 566 ATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVATTVMLE 605 +L+LN+ IA+M +T VA +W+ Q + + +E Sbjct: 633 TYVLLLNMLIALMSETVNHVADNSWSIWKLQKAISVLEME 672 >6BO5-A nrPDB Length = 695 Score = 182 bits (462), Expect = 5e-46, Method: Compositional matrix adjust. Identities = 173/580 (29%), Positives = 282/580 (48%), Gaps = 71/580 (12%) Query: 76 GAVGETALHVAAL--YDNLEAATLLMEAAPELAKEP-----ALC--EPFVGQTALHIAVM 126 G+ G+T L A L D + A + + + + P A C E + G +ALHIA+ Sbjct: 74 GSTGKTCLMKAVLNLQDGVNACIMPLLQIDKDSGNPKPLVNAQCTDEFYQGHSALHIAIE 133 Query: 127 NQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVRLLIEHG 186 ++L V+ L+ GA V RA G F++ Y+GE PLS AAC ++V L+E+ Sbjct: 134 KRSLQCVKLLVENGADVHLRACGRFFQKHQGTCFYFGELPLSLAACTKQWDVVTYLLENP 193 Query: 187 ---ADIRAQDSLGNTVLHILIL-----QPNKTFACQMYNLLLSYDEHSDHLQSLELVPNH 238 A + A DSLGNTVLH L++ N MY+ LL LE + NH Sbjct: 194 HQPASLEATDSLGNTVLHALVMIADNSPENSALVIHMYDGLLQMGARLCPTVQLEEISNH 253 Query: 239 QGLTPFKLAGVEGNTVMFQHLMQK----------RKHVQWTCGPLTSTLYDLTEIDSWGE 288 QGLTP KLA EG +F+H++Q+ RK +W GP+ +LYDL+ +DSW E Sbjct: 254 QGLTPLKLAAKEGKIEIFRHILQREFSGPYQPLSRKFTEWCYGPVRVSLYDLSSVDSW-E 312 Query: 289 ELSFLELVV---SSKKREARQILEQTPVKELVSFKWKKYGRPYFCVLASLYILYMICFTT 345 + S LE++ S R +LE P+ +L+ KW + +F A Y++YM FT Sbjct: 313 KNSVLEIIAFHCKSPNRHRMVVLE--PLNKLLQEKWDRLVSRFFFNFAC-YLVYMFIFTV 369 Query: 346 CCIYRPLKLRDDNRTDPRDITILQQKLLQEAYVTHQDNIRLVGELVTVTGAVIILLLEIP 405 ++P L Q + + T +++ L+G ++ + G + +LL ++ Sbjct: 370 VAYHQP---------------SLDQPAIPSSKATFGESMLLLGHILILLGGIYLLLGQLW 414 Query: 406 DIFRVGASRYFGQTILGGPFHVIIITYASLVLLTMVMRLTNMNGEVVPLSFALVLGWCSV 465 +R + + + F ++ + A L +L+ V+R + L +LVLGW ++ Sbjct: 415 YFWR--RRLFIWISFMDSYFEILFLLQALLTVLSQVLRFMETEWYLPLLVLSLVLGWLNL 472 Query: 466 MYFARGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAF-HITFQTEDP----NNL 520 +Y+ RGFQ G +++MIQK+I DL+RF + V + GFA A ++ + P +N Sbjct: 473 LYYTRGFQHTGIYSVMIQKVILRDLLRFLLVYLVFLFGFAVALVSLSREARSPKAPEDNN 532 Query: 521 GEFSDYPTA------------LFSTFELF-LTIIDGPANYSVDLPF--MYCITYAAFAII 565 ++ PT L ++ ELF TI G + L F + + A+ ++ Sbjct: 533 STVTEQPTVGQEEEPAPYRSILDASLELFKFTIGMGELAFQEQLRFRGVVLLLLLAYVLL 592 Query: 566 ATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVATTVMLE 605 +L+LN+ IA+M +T VA +W+ Q + + +E Sbjct: 593 TYVLLLNMLIALMSETVNHVADNSWSIWKLQKAISVLEME 632 >6OO7-A nrPDB Length = 786 Score = 159 bits (401), Expect = 6e-39, Method: Compositional matrix adjust. Identities = 107/308 (34%), Positives = 161/308 (52%), Gaps = 38/308 (12%) Query: 76 GAVGETALHVAALYDNL-EAATLLMEAAPELAKEPALCEPFV----------GQTALHIA 124 G+ G+T L A L NL + ++ E+ ++ +P V G +ALHIA Sbjct: 112 GSTGKTCLMKAVL--NLQDGVNACIQPLLEIDRDSGNPQPLVNAQCTDEYYRGHSALHIA 169 Query: 125 VMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVRLLIE 184 + ++L V+ L+ GA+V A+A G F+++ Y+GE PLS AAC ++V L+E Sbjct: 170 IEKRSLQCVKLLVENGANVHAKACGHFFQKNQDTCFYFGELPLSLAACTKQWDVVNYLLE 229 Query: 185 H---GADIRAQDSLGNTVLHILIL-----QPNKTFACQMYNLLLSYDEHSDHLQSLELVP 236 + A ++AQDSLGNTVLH L++ N +MY+ LL LE +P Sbjct: 230 NPHQPASLQAQDSLGNTVLHALVMIADDSAENSALVVRMYDGLLQAGARLCPNVQLEGIP 289 Query: 237 NHQGLTPFKLAGVEGNTVMFQHLMQK----------RKHVQWTCGPLTSTLYDLTEIDSW 286 N +GLTP KLA EG +F+H++Q+ RK +W GP+ +LYDL +DSW Sbjct: 290 NLEGLTPLKLAAKEGKIEIFKHILQREFSAPCQSLSRKFTEWCYGPVRVSLYDLASVDSW 349 Query: 287 GEELSFLELVV---SSKKREARQILEQTPVKELVSFKWKKYGRPYFCVLASLYILYMICF 343 EE S LE++ S R +LE P+ +L+ KW + P FC Y++YM+ F Sbjct: 350 -EENSVLEIIAFHSRSPHRHRMVVLE--PLNKLLQAKWDRL-IPRFCFNFLCYLVYMLIF 405 Query: 344 TTCCIYRP 351 T ++P Sbjct: 406 TAVAYHQP 413 >2ETB-A nrPDB Length = 256 Score = 109 bits (272), Expect = 5e-24, Method: Compositional matrix adjust. Identities = 74/206 (35%), Positives = 105/206 (50%), Gaps = 17/206 (8%) Query: 75 RGAVGETALHVAAL--YDNLEAATLLMEAAPELAKEP-----ALC--EPFVGQTALHIAV 125 G+ G+T L A L D + A + + + + P A C E + G +ALHIA+ Sbjct: 39 EGSTGKTCLMKAVLNLQDGVNACIMPLLQIDKDSGNPKPLVNAQCTDEFYQGHSALHIAI 98 Query: 126 MNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVRLLIEH 185 ++L V+ L+ GA V RA G F++ Y+GE PLS AAC ++V L+E+ Sbjct: 99 EKRSLQCVKLLVENGADVHLRACGRFFQKHQGTCFYFGELPLSLAACTKQWDVVTYLLEN 158 Query: 186 ---GADIRAQDSLGNTVLHILIL-----QPNKTFACQMYNLLLSYDEHSDHLQSLELVPN 237 A + A DSLGNTVLH L++ N MY+ LL LE + N Sbjct: 159 PHQPASLEATDSLGNTVLHALVMIADNSPENSALVIHMYDGLLQMGARLCPTVQLEEISN 218 Query: 238 HQGLTPFKLAGVEGNTVMFQHLMQKR 263 HQGLTP KLA EG +F+H++Q+ Sbjct: 219 HQGLTPLKLAAKEGKIEIFRHILQRE 244 >2NYJ-A nrPDB Length = 273 Score = 103 bits (257), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 62/160 (38%), Positives = 87/160 (54%), Gaps = 9/160 (5%) Query: 115 FVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNL-IYYGEHPLSFAACV 173 + GQTALHIA+ +N+ LV L+ GA V A A G F+++ Y+GE PLS AAC Sbjct: 99 YKGQTALHIAIERRNMTLVTLLVENGADVQAAANGDFFKKTKGRPGFYFGELPLSLAACT 158 Query: 174 GSEEIVRLLIEHG---ADIRAQDSLGNTVLHILILQPNKT-----FACQMYNLLLSYDEH 225 IV+ L+++ ADI A+DS+GNTVLH L+ + T F MYN +L Sbjct: 159 NQLAIVKFLLQNSWQPADISARDSVGNTVLHALVEVADNTVDNTKFVTSMYNEILILGAK 218 Query: 226 SDHLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQKRKH 265 LE + N +GLTP LA G + +++Q+ H Sbjct: 219 LHPTLKLEEITNRKGLTPLALAASSGKIGVLAYILQREIH 258 Score = 30.0 bits (66), Expect = 4.2, Method: Compositional matrix adjust. Identities = 18/40 (45%), Positives = 21/40 (52%), Gaps = 2/40 (5%) Query: 48 PLLQAAKENDLRLLKILLLN--QSCDFQQRGAVGETALHV 85 PL AA N L ++K LL N Q D R +VG T LH Sbjct: 151 PLSLAACTNQLAIVKFLLQNSWQPADISARDSVGNTVLHA 190 >2F37-A nrPDB Length = 251 Score = 100 bits (250), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 72/204 (35%), Positives = 104/204 (50%), Gaps = 17/204 (8%) Query: 76 GAVGETALHVAAL--YDNLEAATLLMEAAPELAKEP-----ALC--EPFVGQTALHIAVM 126 G+ G+T L A L D + A L + + P A C + + G +ALHIA+ Sbjct: 45 GSTGKTCLMKAVLNLKDGVNACILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIE 104 Query: 127 NQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVRLLIEH- 185 ++L V+ L+ GA+V ARA G F++ Y+GE PLS AAC ++V L+E+ Sbjct: 105 KRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQWDVVSYLLENP 164 Query: 186 --GADIRAQDSLGNTVLHILIL-----QPNKTFACQMYNLLLSYDEHSDHLQSLELVPNH 238 A ++A DS GNTVLH L++ N MY+ LL LE + N Sbjct: 165 HQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNL 224 Query: 239 QGLTPFKLAGVEGNTVMFQHLMQK 262 Q LTP KLA EG +F+H++Q+ Sbjct: 225 QDLTPLKLAAKEGKIEIFRHILQR 248 >4DX2-A nrPDB Length = 259 Score = 100 bits (248), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 63/157 (40%), Positives = 88/157 (56%), Gaps = 9/157 (5%) Query: 115 FVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFR-RSPHNLIYYGEHPLSFAACV 173 + GQTALHIA+ + + V L+A+GA V A+A G F+ + Y+GE PLS AAC Sbjct: 89 YRGQTALHIAIERRCKHYVELLVAQGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACT 148 Query: 174 GSEEIVRLLIEH---GADIRAQDSLGNTVLHILI-----LQPNKTFACQMYNLLLSYDEH 225 IV L E+ AD+R QDS GNTVLH L+ + N F +MY+LLL Sbjct: 149 NQPHIVNYLTENPHKKADMRRQDSRGNTVLHALVAIADNTRENTKFVTKMYDLLLLKCAR 208 Query: 226 SDHLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQK 262 +LE V N+ GL+P +A G +FQH++++ Sbjct: 209 LFPDSNLEAVLNNDGLSPLMMAAKTGKIGIFQHIIRR 245 >3W9G-A nrPDB Length = 260 Score = 100 bits (248), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 62/157 (39%), Positives = 88/157 (56%), Gaps = 9/157 (5%) Query: 115 FVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFR-RSPHNLIYYGEHPLSFAACV 173 + GQTALHIA+ + + V L+ +GA V A+A G F+ + Y+GE PLS AAC Sbjct: 91 YRGQTALHIAIERRCKHYVELLVEKGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACT 150 Query: 174 GSEEIVRLLIEHG---ADIRAQDSLGNTVLHILI-----LQPNKTFACQMYNLLLSYDEH 225 IV L E+G AD+R QDS GNTVLH L+ + N F +MY+LLL Sbjct: 151 NQPHIVHYLTENGHKQADLRRQDSRGNTVLHALVAIADNTRENTKFVTKMYDLLLIKCAK 210 Query: 226 SDHLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQK 262 +LE + N+ GL+P +A G +FQH++++ Sbjct: 211 LFPDTNLEALLNNDGLSPLMMAAKTGKIGIFQHIIRR 247 >4N5Q-A nrPDB Length = 257 Score = 94.7 bits (234), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 56/157 (35%), Positives = 89/157 (56%), Gaps = 11/157 (7%) Query: 113 EPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFR-RSPHNLIYYGEHPLSFAA 171 E + GQTAL+IA+ + ++ L+A GA V+A A G F + H Y+GE PL+ AA Sbjct: 95 EAYEGQTALNIAIERRQGDITAVLIAAGADVNAHAKGVFFNPKYQHEGFYFGETPLALAA 154 Query: 172 CVGSEEIVRLLIEH-GADIRAQDSLGNTVLHILI-----LQPNKTFACQMYNLLLSYDEH 225 C EIV+LL+E+ DI +QDS GN +LH L+ + F +MY+++L + Sbjct: 155 CTNQPEIVQLLMENEQTDITSQDSRGNNILHALVTVAEDFKTQNDFVKRMYDMILLRSGN 214 Query: 226 SDHLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQK 262 + LE + N+ GLTP +LA G + ++++ + Sbjct: 215 WE----LETMRNNDGLTPLQLAAKMGKAEILKYILSR 247 >5OEO-C nrPDB Length = 73 Score = 88.2 bits (217), Expect = 1e-17, Method: Composition-based stats. Identities = 55/73 (75%), Positives = 61/73 (83%), Gaps = 1/73 (1%) Query: 654 SDKEDGQEQLSEKRPSTVESGMLSRASVAFQTPSLSRTTSQSSNSHRGWEILRRNTLGHL 713 +DKED QE SEK+PS ESG L+RAS+A T SLSRT SQSS SHRGWEILR+NTLGHL Sbjct: 2 ADKEDDQEHPSEKQPSGAESGTLARASLALPTSSLSRTASQSS-SHRGWEILRQNTLGHL 60 Query: 714 NLGLDLGEGDGEE 726 NLGL+L EGDGEE Sbjct: 61 NLGLNLSEGDGEE 73 >5MIO-C nrPDB Length = 573 Score = 74.3 bits (181), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 52/164 (31%), Positives = 81/164 (49%), Gaps = 19/164 (11%) Query: 49 LLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELAKE 108 LL+AA+ +++L+ N D A G T LH+AA Y +LE +L++ +++ Sbjct: 414 LLEAARAGQDDEVRVLMAN-GADVNATDASGLTPLHLAATYGHLEIVEVLLKHGADVS-- 470 Query: 109 PALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLS 168 +G T LH+A + +L +V LL GA V+A T +G+ PL Sbjct: 471 ---ASDLMGSTPLHLAALIGHLEIVEVLLKHGADVNAVDT-------------WGDTPLR 514 Query: 169 FAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFA 212 AA +G +IV L++HGAD+ AQD G T I ++ A Sbjct: 515 LAAVMGHLKIVEALLKHGADVNAQDKFGKTAYDTSIDNGSEDLA 558 Score = 56.2 bits (134), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 54/176 (30%), Positives = 85/176 (48%), Gaps = 27/176 (15%) Query: 116 VGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGS 175 +G+ L A Q+ + VR L+A GA V+A T A+ G PL AA G Sbjct: 410 LGKKLLEAARAGQD-DEVRVLMANGADVNA--TDAS-----------GLTPLHLAATYGH 455 Query: 176 EEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHSDHLQSLELV 235 EIV +L++HGAD+ A D +G+T LH+ L + ++ +LL + + + + Sbjct: 456 LEIVEVLLKHGADVSASDLMGSTPLHLAALIGH----LEIVEVLLKHGADVNAVDTW--- 508 Query: 236 PNHQGLTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLTSTLYDLTEIDSWGEELS 291 G TP +LA V G+ + + L++ V T YD T ID+ E+L+ Sbjct: 509 ----GDTPLRLAAVMGHLKIVEALLKHGADVNAQ-DKFGKTAYD-TSIDNGSEDLA 558 >6MWQ-A nrPDB Length = 493 Score = 70.5 bits (171), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 58/177 (32%), Positives = 81/177 (45%), Gaps = 19/177 (10%) Query: 49 LLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELAKE 108 LL+AA+ ++IL+ N D G T LH+AA +LE +L++ ++ Sbjct: 9 LLEAARAGQDDEVRILMAN-GADVNALDRFGLTPLHLAAQRGHLEIVEVLLKCGADVN-- 65 Query: 109 PALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLS 168 GQT LH+A +L +V LL GA V+A L G+ PL Sbjct: 66 ---AADLWGQTPLHLAATAGHLEIVEVLLKYGADVNA-------------LDLIGKTPLH 109 Query: 169 FAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEH 225 A G EIV +L++HGAD+ AQD G T I I N+ A + L LS H Sbjct: 110 LTAIDGHLEIVEVLLKHGADVNAQDKFGKTAFDISIDNGNEDLAEILQKLNLSDIAH 166 >5H76-A nrPDB Length = 201 Score = 64.3 bits (155), Expect = 2e-10, Method: Composition-based stats. Identities = 59/198 (29%), Positives = 90/198 (45%), Gaps = 26/198 (13%) Query: 49 LLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELAKE 108 LL+AA+ ++IL+ N + D G T LH+AA +LE +L++ ++ Sbjct: 10 LLEAARAGQDDEVRILMANGA-DVNAADNTGTTPLHLAAYSGHLEIVEVLLKHGADVDAS 68 Query: 109 PALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLS 168 G T LH+A +L +V LL GA V+A + G PL Sbjct: 69 DVF-----GYTPLHLAAYWGHLEIVEVLLKNGADVNAMDSD-------------GMTPLH 110 Query: 169 FAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFA--CQMYNLL----LSY 222 AA G EIV +L++HGA + AQD G T I I N+ A Y +L L+ Sbjct: 111 LAAKWGYLEIVEVLLKHGA-VNAQDKFGKTAFDISIDNGNEDLAQILAFYEILHLPNLNE 169 Query: 223 DEHSDHLQSLELVPNHQG 240 ++ + +QSL+ P+ Sbjct: 170 EQRNAFIQSLKDDPSQSA 187 Score = 46.2 bits (108), Expect = 5e-05, Method: Composition-based stats. Identities = 32/87 (36%), Positives = 43/87 (49%), Gaps = 14/87 (16%) Query: 116 VGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGS 175 +G+ L A Q+ + VR L+A GA V+A G PL AA G Sbjct: 6 LGRKLLEAARAGQD-DEVRILMANGADVNAADNT-------------GTTPLHLAAYSGH 51 Query: 176 EEIVRLLIEHGADIRAQDSLGNTVLHI 202 EIV +L++HGAD+ A D G T LH+ Sbjct: 52 LEIVEVLLKHGADVDASDVFGYTPLHL 78 >6FES-A nrPDB Length = 367 Score = 63.2 bits (152), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 50/152 (32%), Positives = 69/152 (45%), Gaps = 19/152 (12%) Query: 47 SPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELA 106 LL+AA+ ++ILL N D G T LH+AA +L +L++ ++ Sbjct: 8 KKLLEAARAGQDDEVRILLAN-GADVNTADETGFTPLHLAAWEGHLGIVEVLLKNGADVN 66 Query: 107 KEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHP 166 G T LH+A +L +V LL GA V+A G P Sbjct: 67 -----ANDERGHTPLHLAAYTGHLEIVEVLLKNGAGVNATDV-------------IGTAP 108 Query: 167 LSFAACVGSEEIVRLLIEHGADIRAQDSLGNT 198 L AA G EEIV +L+++GAD RAQD G T Sbjct: 109 LHLAAMWGHEEIVEVLLKNGADARAQDKFGKT 140 Score = 45.8 bits (107), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 30/86 (34%), Positives = 41/86 (47%), Gaps = 13/86 (15%) Query: 117 GQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSE 176 G T LH+A +L +V LL GA V+A G PL AA G Sbjct: 39 GFTPLHLAAWEGHLGIVEVLLKNGADVNANDE-------------RGHTPLHLAAYTGHL 85 Query: 177 EIVRLLIEHGADIRAQDSLGNTVLHI 202 EIV +L+++GA + A D +G LH+ Sbjct: 86 EIVEVLLKNGAGVNATDVIGTAPLHL 111 Score = 39.7 bits (91), Expect = 0.005, Method: Compositional matrix adjust. Identities = 32/88 (36%), Positives = 44/88 (50%), Gaps = 16/88 (18%) Query: 116 VGQTALHIAVMNQNLNLVRALLARGASV-SARATGAAFRRSPHNLIYYGEHPLSFAACVG 174 +G+ L A Q+ + VR LLA GA V +A TG PL AA G Sbjct: 6 LGKKLLEAARAGQD-DEVRILLANGADVNTADETGFT--------------PLHLAAWEG 50 Query: 175 SEEIVRLLIEHGADIRAQDSLGNTVLHI 202 IV +L+++GAD+ A D G+T LH+ Sbjct: 51 HLGIVEVLLKNGADVNANDERGHTPLHL 78 >5AQA-A nrPDB Length = 418 Score = 60.1 bits (144), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 50/167 (29%), Positives = 76/167 (45%), Gaps = 19/167 (11%) Query: 49 LLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELAKE 108 LL+AA+ ++IL+ N D G T LH+AA +LE +L++ ++ Sbjct: 18 LLEAARAGQDDEVRILMAN-GADVNAADNTGTTPLHLAAYSGHLEIVEVLLKHGADVD-- 74 Query: 109 PALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLS 168 G T LH+A +L +V LL GA V+A + G PL Sbjct: 75 ---ASDVFGYTPLHLAAYWGHLEIVEVLLKNGADVNA-------------MDSDGMTPLH 118 Query: 169 FAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQM 215 AA G +EIV +L++ GAD+ AQD G L + Q + A ++ Sbjct: 119 LAAKWGYKEIVEVLLKAGADVDAQDKFGKRPLWLAADQGHAEIAAKL 165 Score = 44.7 bits (104), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 32/87 (36%), Positives = 43/87 (49%), Gaps = 14/87 (16%) Query: 116 VGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGS 175 +G+ L A Q+ + VR L+A GA V+A G PL AA G Sbjct: 14 LGRKLLEAARAGQD-DEVRILMANGADVNAADN-------------TGTTPLHLAAYSGH 59 Query: 176 EEIVRLLIEHGADIRAQDSLGNTVLHI 202 EIV +L++HGAD+ A D G T LH+ Sbjct: 60 LEIVEVLLKHGADVDASDVFGYTPLHL 86 >5AQB-A nrPDB Length = 428 Score = 59.3 bits (142), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 52/164 (31%), Positives = 75/164 (45%), Gaps = 20/164 (12%) Query: 49 LLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELAKE 108 LL+AA+ +IL+ N D VG T LH+AA + +LE L++ ++ Sbjct: 18 LLEAARAGQDDECRILMAN-GADVNALDEVGWTPLHLAA-WGHLEIVECLLKNGADVN-- 73 Query: 109 PALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLS 168 G T LH+A + +L +V LL GA V+A G PL Sbjct: 74 ---AADIDGYTPLHLAAFSGHLEIVEVLLKYGADVNADD-------------QAGFTPLH 117 Query: 169 FAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFA 212 AA G EIV +L+++GAD+ AQD G T + I N+ A Sbjct: 118 LAAIFGHLEIVEVLLKNGADVNAQDKFGKTPRDLAIDNGNEDIA 161 >5AQ7-A nrPDB Length = 418 Score = 58.5 bits (140), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 50/167 (29%), Positives = 74/167 (44%), Gaps = 19/167 (11%) Query: 49 LLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELAKE 108 LL+AA+ ++ILL N D G T LH+AA +L +L++ ++ Sbjct: 18 LLEAARAGQDDEVRILLAN-GADVNTADETGFTPLHLAAWEGHLGIVEVLLKNGADVN-- 74 Query: 109 PALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLS 168 G T LH+A +L +V LL GA V+A G PL Sbjct: 75 ---ANDERGHTPLHLAAYTGHLEIVEVLLKNGAGVNATDV-------------IGTAPLH 118 Query: 169 FAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQM 215 AA G +EIV +L++ GAD+ AQD G L + Q + A ++ Sbjct: 119 LAAMWGYKEIVEVLLKAGADVDAQDKFGKRPLWLAADQGHAEIAAKL 165 Score = 38.1 bits (87), Expect = 0.012, Method: Compositional matrix adjust. Identities = 32/88 (36%), Positives = 44/88 (50%), Gaps = 16/88 (18%) Query: 116 VGQTALHIAVMNQNLNLVRALLARGASV-SARATGAAFRRSPHNLIYYGEHPLSFAACVG 174 +G+ L A Q+ + VR LLA GA V +A TG PL AA G Sbjct: 14 LGKKLLEAARAGQD-DEVRILLANGADVNTADETGFT--------------PLHLAAWEG 58 Query: 175 SEEIVRLLIEHGADIRAQDSLGNTVLHI 202 IV +L+++GAD+ A D G+T LH+ Sbjct: 59 HLGIVEVLLKNGADVNANDERGHTPLHL 86 >5AQ9-A nrPDB Length = 422 Score = 52.8 bits (125), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 44/137 (32%), Positives = 60/137 (43%), Gaps = 24/137 (17%) Query: 116 VGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGS 175 G T LH+A + +L +V LL GA V A +G PL AA G Sbjct: 46 TGTTPLHLAAYSGHLEIVEVLLKHGADVDASDV-------------FGYTPLHLAAYWGH 92 Query: 176 EEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHSDHLQSLELV 235 EIV +L+++GAD+ A DS G T LH+ K ++ +LL + + Sbjct: 93 LEIVEVLLKNGADVNAMDSDGMTPLHLAA----KWGYLEIVEVLLKHGADVNAQDKF--- 145 Query: 236 PNHQGLTPFKLAGVEGN 252 G TPF LA GN Sbjct: 146 ----GKTPFDLADDNGN 158 Score = 45.8 bits (107), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 49/190 (25%), Positives = 81/190 (42%), Gaps = 26/190 (13%) Query: 116 VGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGS 175 +G+ L A Q+ + VR L+A GA V+A G PL AA G Sbjct: 14 LGRKLLEAARAGQD-DEVRILMANGADVNAADN-------------TGTTPLHLAAYSGH 59 Query: 176 EEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHSDHLQSLELV 235 EIV +L++HGAD+ A D G T LH+ + ++ +LL + + S Sbjct: 60 LEIVEVLLKHGADVDASDVFGYTPLHLAAYWGH----LEIVEVLLKNGADVNAMDS---- 111 Query: 236 PNHQGLTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLTSTLYDLTEIDSWGEELSFLEL 295 G+TP LA G + + L++ V T +DL + + + + L++ Sbjct: 112 ---DGMTPLHLAAKWGYLEIVEVLLKHGADVN-AQDKFGKTPFDLADDNGNDDVGTLLQV 167 Query: 296 VVSSKKREAR 305 ++ + AR Sbjct: 168 AAAADQLGAR 177 >6AUN-A nrPDB Length = 752 Score = 51.2 bits (121), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 67/241 (27%), Positives = 102/241 (42%), Gaps = 51/241 (21%) Query: 47 SPLLQAAKENDLRLLKILLLNQSCDFQQ--RGAVGETALHVAALYDNLEAATLLMEAAP- 103 +PL A ++ D +L L+ Q C Q GETA H A DN + LL + A Sbjct: 154 TPLHLACRKGDSEILVELV--QYCHAQMDVTDNKGETAFHYAVQGDNSQVLQLLGKNASA 211 Query: 104 ---ELAKEPALCEPFVGQTALHIAVMNQNLNLVRALL---AR----GASVSARATGAAF- 152 ++ K+ G T LH+A +VR LL AR G S T F Sbjct: 212 GLNQVNKQ--------GLTPLHLACQMGKQEMVRVLLLCNARCNVMGPSGFPIHTAMKFS 263 Query: 153 RRSPHNLIY-------------YGEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTV 199 ++ +I YG PL +A + E+ R+L++ G D+ + + GNT Sbjct: 264 QKGCAEMIISMDSSQIHSKDPRYGASPLHWAK---NAEMARMLLKRGCDVDSTSAAGNTA 320 Query: 200 LHILILQPNKTFACQMYNLLLSYDEHSDHLQSLELVPNHQGLTPFKLAGVEGNTVMFQHL 259 LH+ +++ F C M +LL+Y ++ P G TP LA + N M + L Sbjct: 321 LHVAVMR--NRFDCVM--VLLTYGANAG-------TPGEHGNTPLHLAISKDNMEMIKAL 369 Query: 260 M 260 + Sbjct: 370 I 370 Score = 46.6 bits (109), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 26/80 (32%), Positives = 40/80 (50%), Gaps = 5/80 (6%) Query: 64 LLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELAKEPALCEPFVGQTALHI 123 +LL + CD A G TALHVA + + + +L+ A P G T LH+ Sbjct: 302 MLLKRGCDVDSTSAAGNTALHVAVMRNRFDCVMVLLTYGAN-AGTPGEH----GNTPLHL 356 Query: 124 AVMNQNLNLVRALLARGASV 143 A+ N+ +++AL+ GA V Sbjct: 357 AISKDNMEMIKALIVFGAEV 376 Score = 41.2 bits (95), Expect = 0.002, Method: Compositional matrix adjust. Identities = 33/120 (27%), Positives = 50/120 (41%), Gaps = 21/120 (17%) Query: 79 GETALHVAALYDNLEAATLLMEAAPELAKEPALCEPFVGQTALHIAVMNQNLNLVRALLA 138 G + LH A N E A +L++ ++ A G TALH+AVM + V LL Sbjct: 287 GASPLHWAK---NAEMARMLLKRGCDVDSTSA-----AGNTALHVAVMRNRFDCVMVLLT 338 Query: 139 RGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNT 198 GA+ +G PL A + E+++ LI GA++ + G T Sbjct: 339 YGANAGTPGE-------------HGNTPLHLAISKDNMEMIKALIVFGAEVDTPNDFGET 385 >4Z68-A nrPDB Length = 155 Score = 49.7 bits (117), Expect = 4e-06, Method: Composition-based stats. Identities = 45/159 (28%), Positives = 69/159 (43%), Gaps = 20/159 (12%) Query: 46 DSPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPEL 105 D LL+AAK D+ +K L QS + + T LH AA Y+ + L++ ++ Sbjct: 4 DRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADV 63 Query: 106 -AKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGE 164 AK+ G LH A + + L+ GA V+ + Sbjct: 64 HAKDKG------GLVPLHNACSYGHYEVAELLVKHGAVVNVAD-------------LWKF 104 Query: 165 HPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHIL 203 PL AA G EI +LL++HGAD ++ GNT L ++ Sbjct: 105 TPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLV 143 >5CBO-A nrPDB Length = 176 Score = 48.1 bits (113), Expect = 1e-05, Method: Composition-based stats. Identities = 33/96 (34%), Positives = 44/96 (45%), Gaps = 13/96 (13%) Query: 117 GQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSE 176 G T LH+A + +V LL GA V+A G+ PL AA G Sbjct: 36 GVTPLHLAAYWGHFEIVEVLLKYGADVNASDAT-------------GDTPLHLAAKWGYL 82 Query: 177 EIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFA 212 IV +L+++GAD+ AQD G T I I N+ A Sbjct: 83 GIVEVLLKYGADVNAQDKFGKTAFDISIDNGNEDLA 118 Score = 46.6 bits (109), Expect = 4e-05, Method: Composition-based stats. Identities = 31/87 (35%), Positives = 46/87 (52%), Gaps = 14/87 (16%) Query: 116 VGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGS 175 +G+ L A Q+ + VR L+A GA V+A +G PL AA G Sbjct: 3 LGKKLLEAAHAGQD-DEVRILMANGADVNAMDN-------------FGVTPLHLAAYWGH 48 Query: 176 EEIVRLLIEHGADIRAQDSLGNTVLHI 202 EIV +L+++GAD+ A D+ G+T LH+ Sbjct: 49 FEIVEVLLKYGADVNASDATGDTPLHL 75 Score = 33.1 bits (74), Expect = 0.39, Method: Composition-based stats. Identities = 26/99 (26%), Positives = 45/99 (45%), Gaps = 6/99 (6%) Query: 47 SPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELA 106 +PL AA ++++LL D A G+T LH+AA + L +L++ ++ Sbjct: 38 TPLHLAAYWGHFEIVEVLL-KYGADVNASDATGDTPLHLAAKWGYLGIVEVLLKYGADVN 96 Query: 107 KEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSA 145 + G+TA I++ N N +L L A +A Sbjct: 97 AQDKF-----GKTAFDISIDNGNEDLAEILCKNKAQQAA 130 >5GP7-A nrPDB Length = 169 Score = 44.7 bits (104), Expect = 1e-04, Method: Composition-based stats. Identities = 42/157 (26%), Positives = 68/157 (43%), Gaps = 18/157 (11%) Query: 46 DSPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPEL 105 D+ LL AAK+ L ++ L ++ + + T LH+AA Y+NLE A L+E ++ Sbjct: 10 DAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADV 69 Query: 106 AKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEH 165 + G LH A ++++ L+ V+A A Sbjct: 70 NAQDK-----GGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAF-------------T 111 Query: 166 PLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHI 202 PL AA G ++ LL+ HGAD ++ G T L + Sbjct: 112 PLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDL 148 >4OAU-C nrPDB Length = 699 Score = 43.5 bits (101), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 53/205 (25%), Positives = 94/205 (45%), Gaps = 17/205 (8%) Query: 64 LLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELAKEPALCEPFVGQTALHI 123 LLL D R G T +AA+ +++ L + ++ + C+ F G TA Sbjct: 57 LLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNE----CD-FYGFTAFME 111 Query: 124 AVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVRLLI 183 A + + ++ L RGA+V+ R + L G L AA G E++++L+ Sbjct: 112 AAVYGKVKALKFLYKRGANVNLRRKT---KEDQERLRKGGATALMDAAEKGHVEVLKILL 168 Query: 184 -EHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHSDHLQSLELVPNHQGLT 242 E GAD+ A D++G L +L + + + +LLL DH + V +G T Sbjct: 169 DEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLL------DHGADVN-VRGERGKT 221 Query: 243 PFKLAGVEGNTVMFQHLMQKRKHVQ 267 P LA + + + Q L++ ++H++ Sbjct: 222 PLILAVEKKHLGLVQRLLE-QEHIE 245 Score = 36.2 bits (82), Expect = 0.058, Method: Compositional matrix adjust. Identities = 45/160 (28%), Positives = 69/160 (43%), Gaps = 16/160 (10%) Query: 47 SPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPEL- 105 +P + AA ++LLK L L++ D + G TA AA+Y ++A L + + Sbjct: 74 TPFILAAIAGSVKLLK-LFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVN 132 Query: 106 ----AKEPALCEPFVGQTALHIAVMNQNLNLVRALLAR-GASVSARATGAAFRRSPHNLI 160 KE G TAL A ++ +++ LL GA V+A + LI Sbjct: 133 LRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNA-----CDNMGRNALI 187 Query: 161 YYGEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVL 200 H L + E I LL++HGAD+ + G T L Sbjct: 188 ----HALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPL 223 Score = 35.4 bits (80), Expect = 0.089, Method: Compositional matrix adjust. Identities = 22/65 (33%), Positives = 34/65 (52%), Gaps = 12/65 (18%) Query: 124 AVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVRLLI 183 AV N++++LV+ LL GA+V+ + + PL A + E+IV LL+ Sbjct: 12 AVQNEDVDLVQQLLEGGANVNFQEEEGGWT------------PLHNAVQMSREDIVELLL 59 Query: 184 EHGAD 188 HGAD Sbjct: 60 RHGAD 64 >6G1K-A nrPDB Length = 921 Score = 43.1 bits (100), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 34/136 (25%), Positives = 68/136 (50%), Gaps = 17/136 (12%) Query: 475 LGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFH-ITFQTEDPNNL---GEFSDYPTAL 530 LGP I + +M+ D+++F ++ +V+L FA+ + + F E+ + G + Sbjct: 502 LGPLQISLGRMLL-DILKFLFIYCLVLLAFANGLNQLYFYYENSEGMTCKGIRCERQNNA 560 Query: 531 FST-FE----LFLTIIDGPANYSVDLP-------FMYCITYAAFAIIATLLMLNLFIAMM 578 FST FE LF +I + Y ++ F+ + + +I+ +++LN+ IAMM Sbjct: 561 FSTLFETLQSLFWSIFGLISLYVTNVKADHKFTEFVGATMFGTYNVISLVVLLNMLIAMM 620 Query: 579 GDTHWRVAQERDELWR 594 +++ +A D W+ Sbjct: 621 NNSYQHIADHADIEWK 636 >5Z96-A nrPDB Length = 755 Score = 43.1 bits (100), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 32/136 (23%), Positives = 65/136 (47%), Gaps = 17/136 (12%) Query: 475 LGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFH-ITFQTEDPNNLG-------EFSDY 526 LGP I + +M+ D+++F ++ +V+L FA+ + + F E+ L + ++ Sbjct: 502 LGPLQISLGRMLL-DILKFLFIYCLVLLAFANGLNQLYFYYEETKGLSCKGIRCEKQNNA 560 Query: 527 PTALFSTFELFLTIIDGPANYSVD--------LPFMYCITYAAFAIIATLLMLNLFIAMM 578 + LF T + I G N V F+ + + +I+ +++LN+ IAMM Sbjct: 561 FSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNMLIAMM 620 Query: 579 GDTHWRVAQERDELWR 594 +++ +A D W+ Sbjct: 621 NNSYQLIADHADIEWK 636 >3B7B-A nrPDB Length = 237 Score = 42.0 bits (97), Expect = 0.001, Method: Composition-based stats. Identities = 46/173 (26%), Positives = 77/173 (44%), Gaps = 32/173 (18%) Query: 36 VNMLQQERIRDSPLLQAAKENDLRLLKILLLN----QSCDFQQRGAVGETALHVAALYDN 91 +N + + + SPL AA+ + + +L+ +C QR T L AA ++ Sbjct: 2 MNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQR-----TPLMEAAENNH 56 Query: 92 LEAATLLMEAAPELAKEPALCEP--FVGQTALHIAVMNQNLNLVRALLARGA-SVSARAT 148 LEA L++A AL +P G T LH+A + +V+ LL+ G V+ + Sbjct: 57 LEAVKYLIKAG-------ALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDD 109 Query: 149 GAAFRRSPHNLIYYGEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLH 201 G G P+ +A ++V+LL+ G+DI +D+ N LH Sbjct: 110 G-------------GWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLH 149 Score = 30.4 bits (67), Expect = 2.9, Method: Composition-based stats. Identities = 26/100 (26%), Positives = 45/100 (45%), Gaps = 6/100 (6%) Query: 47 SPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELA 106 +P++ A + + L+K LLL++ D R LH AA ++ A +L+ A +L Sbjct: 113 TPMIWATEYKHVDLVK-LLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLH 171 Query: 107 KEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSAR 146 G + LHIA + V L+R + V+ + Sbjct: 172 -----AVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLK 206 >4OT9-A nrPDB Length = 359 Score = 41.2 bits (95), Expect = 0.002, Method: Compositional matrix adjust. Identities = 28/78 (35%), Positives = 42/78 (53%), Gaps = 14/78 (17%) Query: 117 GQTALHIAVMNQNLNLVRALLAR-GASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGS 175 G+TALH+A + L LV L+ + A+V+AR + G PL AA +G Sbjct: 228 GRTALHLATEMEELGLVTHLVTKLRANVNAR-------------TFAGNTPLHLAAGLGY 274 Query: 176 EEIVRLLIEHGADIRAQD 193 + RLL++ GADI A++ Sbjct: 275 PTLTRLLLKAGADIHAEN 292 Score = 33.1 bits (74), Expect = 0.41, Method: Compositional matrix adjust. Identities = 35/126 (27%), Positives = 59/126 (46%), Gaps = 16/126 (12%) Query: 80 ETALHVAALYDNLEAATLLMEAAPELAKEPALCEPFVGQTALHIAVMNQN--LNLVRALL 137 +T LH+A + + L+ + +PAL + G +A+H+A+ L+RALL Sbjct: 122 QTPLHLAVITGQTSVVSFLLR----VGADPALLDRH-GDSAMHLALRAGAGAPELLRALL 176 Query: 138 ARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGN 197 GA A + H + G +P+ A S E + LL++ GA++ A + G Sbjct: 177 QSGAP--------AVPQLLHMPDFEGLYPVHLAVRARSPECLDLLVDSGAEVEATERQGG 228 Query: 198 -TVLHI 202 T LH+ Sbjct: 229 RTALHL 234 Score = 28.9 bits (63), Expect = 9.3, Method: Compositional matrix adjust. Identities = 34/126 (26%), Positives = 54/126 (42%), Gaps = 16/126 (12%) Query: 136 LLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVRLLIEHGADIRAQDSL 195 +L R +AR G A +RS L+ YG + A G + + AQD Sbjct: 33 MLQRAREYNARLFGLA-QRSARALLDYGVTADARALLAGQRHL----------LTAQDEN 81 Query: 196 GNTVLHILILQPNKTFACQMYNLLLSYDEHSDHLQSLELVPNHQGLTPFKLAGVEGNTVM 255 G+T LH+ I+ + Q+ ++ H+ L + L NH TP LA + G T + Sbjct: 82 GDTPLHLAIIHGQTSVIEQIVYVI----HHAQDLGVVNLT-NHLHQTPLHLAVITGQTSV 136 Query: 256 FQHLMQ 261 L++ Sbjct: 137 VSFLLR 142 >6BY9-A nrPDB Length = 328 Score = 38.9 bits (89), Expect = 0.008, Method: Compositional matrix adjust. Identities = 46/172 (26%), Positives = 76/172 (44%), Gaps = 32/172 (18%) Query: 37 NMLQQERIRDSPLLQAAKENDLRLLKILLLN----QSCDFQQRGAVGETALHVAALYDNL 92 N + + + SPL AA+ + + +L+ +C QR T L AA ++L Sbjct: 94 NFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQR-----TPLMEAAENNHL 148 Query: 93 EAATLLMEAAPELAKEPALCEP--FVGQTALHIAVMNQNLNLVRALLARGA-SVSARATG 149 EA L++A AL +P G T LH+A + +V+ LL+ G V+ + G Sbjct: 149 EAVKYLIKAG-------ALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDG 201 Query: 150 AAFRRSPHNLIYYGEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLH 201 G P+ +A ++V+LL+ G+DI +D+ N LH Sbjct: 202 -------------GWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLH 240 >5HKP-A nrPDB Length = 351 Score = 38.9 bits (89), Expect = 0.008, Method: Compositional matrix adjust. Identities = 36/113 (31%), Positives = 53/113 (46%), Gaps = 20/113 (17%) Query: 113 EPFVGQTALHIAVMN---QNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSF 169 +P +TALH AV + + + LL +GA+V+ + N + PL Sbjct: 207 QPQSHETALHCAVASLHPKRKQVAELLLRKGANVNEK-----------NKDFMT--PLHV 253 Query: 170 AACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSY 222 AA +++ +L +HGA + A DSLG T LH L + Q LLLSY Sbjct: 254 AAERAHNDVMEVLHKHGAKMNALDSLGQTALHRAALAGH----LQTCRLLLSY 302 Score = 35.8 bits (81), Expect = 0.071, Method: Compositional matrix adjust. Identities = 43/143 (30%), Positives = 70/143 (48%), Gaps = 22/143 (15%) Query: 49 LLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALH--VAALY-DNLEAATLLMEAAPEL 105 LLQAA+E DL +K L + +F+Q + ETALH VA+L+ + A LL+ + Sbjct: 182 LLQAAREADLAKVKKTLALEIINFKQPQS-HETALHCAVASLHPKRKQVAELLLRKGANV 240 Query: 106 AKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEH 165 ++ + F+ T LH+A + +++ L GA ++A L G+ Sbjct: 241 NEKN---KDFM--TPLHVAAERAHNDVMEVLHKHGAKMNA-------------LDSLGQT 282 Query: 166 PLSFAACVGSEEIVRLLIEHGAD 188 L AA G + RLL+ +G+D Sbjct: 283 ALHRAALAGHLQTCRLLLSYGSD 305 Score = 34.7 bits (78), Expect = 0.15, Method: Compositional matrix adjust. Identities = 17/36 (47%), Positives = 22/36 (61%) Query: 166 PLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLH 201 PL AA IV+LL++HGAD+ A+D G LH Sbjct: 61 PLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLH 96 >4NIK-A nrPDB Length = 230 Score = 38.9 bits (89), Expect = 0.009, Method: Composition-based stats. Identities = 38/143 (26%), Positives = 61/143 (42%), Gaps = 27/143 (18%) Query: 81 TALHVAALYDNLEAATLLME-AAPELAKEPALCEPFVGQTALHIAVMNQNLNLVRALLAR 139 TALH A + E L++ P K+ A G + LHIA +V+ALL + Sbjct: 46 TALHWACSAGHTEIVEFLLQLGVPVNDKDDA------GWSPLHIAASAGRDEIVKALLGK 99 Query: 140 GASVSARATGA------AFRRSPHNLI--------------YYGEHPLSFAACVGSEEIV 179 GA V+A A ++ H + +Y + AA G+ +++ Sbjct: 100 GAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMI 159 Query: 180 RLLIEHGADIRAQDSLGNTVLHI 202 +L+ + A QD+ GNT LH+ Sbjct: 160 HILLYYKASTNIQDTEGNTPLHL 182 Score = 36.6 bits (83), Expect = 0.039, Method: Composition-based stats. Identities = 27/84 (32%), Positives = 37/84 (44%), Gaps = 13/84 (15%) Query: 118 QTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEE 177 +TALH A + +V LL G V+ + G PL AA G +E Sbjct: 45 RTALHWACSAGHTEIVEFLLQLGVPVNDKDDA-------------GWSPLHIAASAGRDE 91 Query: 178 IVRLLIEHGADIRAQDSLGNTVLH 201 IV+ L+ GA + A + G T LH Sbjct: 92 IVKALLGKGAQVNAVNQNGCTPLH 115 Score = 36.2 bits (82), Expect = 0.057, Method: Composition-based stats. Identities = 45/158 (28%), Positives = 63/158 (39%), Gaps = 23/158 (14%) Query: 47 SPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLME--AAPE 104 SPL AA ++K LL + G T LH AA + E A +L+E A P+ Sbjct: 79 SPLHIAASAGRDEIVKALL-GKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 137 Query: 105 LAKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGE 164 AK+ TA+H A NL ++ LL AS + + T G Sbjct: 138 -AKD------HYEATAMHRAAAKGNLKMIHILLYYKASTNIQDT-------------EGN 177 Query: 165 HPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHI 202 PL A E +LL+ GA I ++ T L + Sbjct: 178 TPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQV 215 >1BLX-B nrPDB Length = 166 Score = 38.1 bits (87), Expect = 0.015, Method: Compositional matrix adjust. Identities = 28/97 (28%), Positives = 46/97 (47%), Gaps = 12/97 (12%) Query: 155 SPHNLIYYGEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQ 214 SP+ G P+ AA G + +++L+EHGAD+ A DS G+ +H+ I + + + Sbjct: 66 SPNVQDASGTSPVHDAARTGFLDTLKVLVEHGADVNALDSTGSLPIHLAIREGHSSVVS- 124 Query: 215 MYNLLLSYDEHSDHLQSLELVPNHQGLTPFKLAGVEG 251 L+ + H + GLTP +LA G Sbjct: 125 ----FLAPESDLHHRDA-------SGLTPLELARQRG 150 >4O1O-A nrPDB Length = 717 Score = 38.1 bits (87), Expect = 0.015, Method: Compositional matrix adjust. Identities = 48/168 (28%), Positives = 74/168 (44%), Gaps = 16/168 (9%) Query: 47 SPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPEL- 105 +P + A ++RLL++LL N D + G TA AA+Y +EA L E ++ Sbjct: 77 TPFIIAGITGNVRLLQLLLPNVE-DVNECDVNGFTAFMEAAVYGRVEALRFLYENGADVN 135 Query: 106 ----AKEPALCEPFVGQTALHIAVMNQNLNLVRALL-ARGASVSARATGAAFRRSPHNLI 160 K+ G TAL A ++ +V LL A A V AR + L+ Sbjct: 136 MHRKTKQDQERIRKGGATALMDAAEKGHVGVVTILLHAMKAEVDARDN-----MGRNALV 190 Query: 161 YYGEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPN 208 Y +P A + I RLL++HGAD+ + T L + + + N Sbjct: 191 YALLNPDDGKA----KAITRLLLDHGADVNVRGEGSKTPLILAVERKN 234 Score = 36.2 bits (82), Expect = 0.048, Method: Compositional matrix adjust. Identities = 29/83 (34%), Positives = 40/83 (48%), Gaps = 17/83 (20%) Query: 106 AKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEH 165 A +PA E + Q AV ++ VR LL RGA A F+ +G Sbjct: 2 AMDPASLEEMLTQ-----AVQEADIEQVRQLLERGAD-------ANFQEEE-----WGWS 44 Query: 166 PLSFAACVGSEEIVRLLIEHGAD 188 PL A + SE++V LL++HGAD Sbjct: 45 PLHSAVQMDSEDLVALLLKHGAD 67 Score = 35.0 bits (79), Expect = 0.11, Method: Compositional matrix adjust. Identities = 68/259 (26%), Positives = 108/259 (41%), Gaps = 25/259 (9%) Query: 13 AQLQKLLISWPVGEQDWEQYRDRVNM-----LQQERIRDSPLLQAAKENDLRLLKILLLN 67 A L+++L + V E D EQ R + Q+E SPL +A + D L LLL Sbjct: 6 ASLEEML-TQAVQEADIEQVRQLLERGADANFQEEEWGWSPL-HSAVQMDSEDLVALLLK 63 Query: 68 QSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELAKEPALCEPFVGQTALHIAVMN 127 D R G T +A + N+ LL+ ++ + C+ G TA A + Sbjct: 64 HGADPCLRKRNGATPFIIAGITGNVRLLQLLLPNVEDVNE----CD-VNGFTAFMEAAVY 118 Query: 128 QNLNLVRALLARGASVSA-RATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVRLLIEH- 185 + +R L GA V+ R T ++ + G L AA G +V +L+ Sbjct: 119 GRVEALRFLYENGADVNMHRKT----KQDQERIRKGGATALMDAAEKGHVGVVTILLHAM 174 Query: 186 GADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHSDHLQSLELVPNHQGLTPFK 245 A++ A+D++G L +L P+ A + LLL DH + V TP Sbjct: 175 KAEVDARDNMGRNALVYALLNPDDGKAKAITRLLL------DHGADVN-VRGEGSKTPLI 227 Query: 246 LAGVEGNTVMFQHLMQKRK 264 LA N + Q L+++ + Sbjct: 228 LAVERKNLDLVQMLLEQEQ 246 >3EU9-A nrPDB Length = 240 Score = 37.7 bits (86), Expect = 0.016, Method: Compositional matrix adjust. Identities = 43/179 (24%), Positives = 75/179 (41%), Gaps = 27/179 (15%) Query: 52 AAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELAKEPAL 111 AA N + L+K + + Q G + T LH A +L LM+ +P+L Sbjct: 49 AAINNRIDLVKYYISKGAIVDQLGGDLNSTPLHWATRQGHLSMVVQLMK----YGADPSL 104 Query: 112 CEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATG-------AAFRR---SPHNLI- 160 + G + +H+A + ++V L+A+G V AA+R P L+ Sbjct: 105 IDGE-GCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNGMTPLMWAAYRTHSVDPTRLLL 163 Query: 161 -----------YYGEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPN 208 Y+ L +A G+ ++ LL+E GA++ AQ+ G + L + + N Sbjct: 164 TFNVSVNLGDKYHKNTALHWAVLAGNTTVISLLLEAGANVDAQNIKGESALDLAKQRKN 222 Score = 33.9 bits (76), Expect = 0.25, Method: Compositional matrix adjust. Identities = 42/171 (24%), Positives = 67/171 (39%), Gaps = 34/171 (19%) Query: 119 TALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHN-------------LIYYGEH 165 T LH A +N ++LV+ +++GA V G +P + L+ YG Sbjct: 44 TLLHWAAINNRIDLVKYYISKGAIVD--QLGGDLNSTPLHWATRQGHLSMVVQLMKYGAD 101 Query: 166 P----------LSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQM 215 P + AA G IV LI G D+ D G T L+ +T + Sbjct: 102 PSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNGMTP---LMWAAYRTHSVDP 158 Query: 216 YNLLLSYDEHSDHLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHV 266 LLL+++ S+ L + T A + GNT + L++ +V Sbjct: 159 TRLLLTFNV------SVNLGDKYHKNTALHWAVLAGNTTVISLLLEAGANV 203 >5JHQ-A nrPDB Length = 482 Score = 37.7 bits (86), Expect = 0.018, Method: Compositional matrix adjust. Identities = 57/195 (29%), Positives = 89/195 (45%), Gaps = 37/195 (18%) Query: 47 SPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATL------LME 100 +PL +AA +N + + LLL+ D G++A+ +A + E T L++ Sbjct: 270 TPLHEAASKNRVEVCS-LLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQ 328 Query: 101 AAPE--LAK-EPALC-------EPFVGQTALHIAVMN---QNLNLVRALLARGASVSARA 147 AA E LAK + L +P +TALH AV + + + LL +GA+V+ + Sbjct: 329 AAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEK- 387 Query: 148 TGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQP 207 N + PL AA +++ +L +HGA + A D+LG T LH L Sbjct: 388 ----------NKDFMT--PLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAG 435 Query: 208 NKTFACQMYNLLLSY 222 + Q LLLSY Sbjct: 436 H----LQTCRLLLSY 446 Score = 35.8 bits (81), Expect = 0.070, Method: Compositional matrix adjust. Identities = 44/144 (30%), Positives = 66/144 (45%), Gaps = 24/144 (16%) Query: 49 LLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALH--VAALYDNLEAAT--LLMEAAPE 104 LLQAA+E DL +K L + +F+Q + ETALH VA+L+ + T LL + A Sbjct: 326 LLQAAREADLAKVKKTLALEIINFKQPQS-HETALHCAVASLHPKRKQVTELLLRKGANV 384 Query: 105 LAKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGE 164 K P LH+A + +++ L GA ++A L G+ Sbjct: 385 NEKNKDFMTP------LHVAAERAHNDVMEVLHKHGAKMNA-------------LDTLGQ 425 Query: 165 HPLSFAACVGSEEIVRLLIEHGAD 188 L AA G + RLL+ +G+D Sbjct: 426 TALHRAALAGHLQTCRLLLSYGSD 449 Score = 34.3 bits (77), Expect = 0.17, Method: Compositional matrix adjust. Identities = 17/36 (47%), Positives = 22/36 (61%) Query: 166 PLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLH 201 PL AA IV+LL++HGAD+ A+D G LH Sbjct: 205 PLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLH 240 Score = 34.3 bits (77), Expect = 0.18, Method: Compositional matrix adjust. Identities = 28/83 (33%), Positives = 36/83 (43%), Gaps = 13/83 (15%) Query: 119 TALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEI 178 + LH A ++V LL GA+V AR G PL A G E+ Sbjct: 51 SPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLI-------------PLHNACSFGHAEV 97 Query: 179 VRLLIEHGADIRAQDSLGNTVLH 201 V LL+ GAD A+D+ T LH Sbjct: 98 VSLLLCQGADPNARDNWNYTPLH 120 Score = 30.0 bits (66), Expect = 4.1, Method: Compositional matrix adjust. Identities = 37/153 (24%), Positives = 66/153 (43%), Gaps = 20/153 (13%) Query: 49 LLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPEL-AK 107 LL+A + D+ +K L+ + + + + LH AA + + L++ + A+ Sbjct: 19 LLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHAR 78 Query: 108 EPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPL 167 + G LH A + +V LL +GA +AR N Y PL Sbjct: 79 DDG------GLIPLHNACSFGHAEVVSLLLCQGADPNAR----------DNWNYT---PL 119 Query: 168 SFAACVGSEEIVRLLIEHGADIRAQDSLGNTVL 200 AA G ++ +L++HGAD +++ G + L Sbjct: 120 HEAAIKGKIDVCIVLLQHGADPNIRNTDGKSAL 152 >5ET1-A nrPDB Length = 353 Score = 36.2 bits (82), Expect = 0.049, Method: Compositional matrix adjust. Identities = 55/201 (27%), Positives = 76/201 (37%), Gaps = 33/201 (16%) Query: 2 GACP---PKAKGPWAQLQKLLISWPVGEQDWEQYRDRVNMLQQERIRDSPLLQAAKENDL 58 GA P AKG L+ L+ +P G VN Q +PL A +E L Sbjct: 139 GALPIHYAAAKGDLPSLKLLVGHYPEG----------VNA--QTNNGATPLYLACQEGHL 186 Query: 59 RLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELAKEPALCEPFVGQ 118 + K L+ S D R G T LH AA + L+ A E + G Sbjct: 187 EVTKYLVQECSADPHLRAQDGMTPLHAAAQMGHNPVLVWLVSFADVSFSE----QDHDGA 242 Query: 119 TALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEI 178 TA+H A + ++ LL GA +S +G PL AA G E Sbjct: 243 TAMHFAASRGHTKVLSWLLLHGAEISQD--------------LWGGTPLHDAAENGELEC 288 Query: 179 VRLLIEHGADIRAQDSLGNTV 199 ++L +GA + +D G T Sbjct: 289 CQILAVNGAGLDVRDHDGYTA 309 >1WG0-A nrPDB Length = 243 Score = 36.2 bits (82), Expect = 0.051, Method: Compositional matrix adjust. Identities = 37/158 (23%), Positives = 63/158 (39%), Gaps = 13/158 (8%) Query: 44 IRDSPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAP 103 + + PL QA EN+ ++ LL ++ Q+ G LH + + E + L+ Sbjct: 1 MSNYPLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKME 60 Query: 104 ELAKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYG 163 + + + G T HIA NL +V++L R + + + G Sbjct: 61 NVNLDDYPDDS--GWTPFHIACSVGNLEVVKSLYDR-----------PLKPDLNKITNQG 107 Query: 164 EHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLH 201 L A E+ + LIE+GA +R +D LH Sbjct: 108 VTCLHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLH 145 >5DND-A nrPDB Length = 588 Score = 34.7 bits (78), Expect = 0.14, Method: Compositional matrix adjust. Identities = 35/102 (34%), Positives = 44/102 (43%), Gaps = 18/102 (17%) Query: 92 LEAATLLMEAAPELAKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAA 151 LEA LME +L + + GQT LH+A N +V LL RG V+AR Sbjct: 435 LEALQALMELGSDLRLKDS-----NGQTLLHVAARNGRDGVVTMLLHRGMDVNARDRDGL 489 Query: 152 FRRSPHNLIYYGEHPLSFAACVGSEEIVRLLIEHGADIRAQD 193 SP L G H E +RLL + GA + QD Sbjct: 490 ---SPLLLAVQGRH----------RECIRLLRKAGACLSPQD 518 Score = 30.8 bits (68), Expect = 2.3, Method: Compositional matrix adjust. Identities = 14/32 (43%), Positives = 22/32 (68%) Query: 171 ACVGSEEIVRLLIEHGADIRAQDSLGNTVLHI 202 A G E ++ L+E G+D+R +DS G T+LH+ Sbjct: 430 AHAGELEALQALMELGSDLRLKDSNGQTLLHV 461 >2KXP-C nrPDB Length = 118 Score = 34.7 bits (78), Expect = 0.15, Method: Composition-based stats. Identities = 23/70 (32%), Positives = 33/70 (47%), Gaps = 13/70 (18%) Query: 124 AVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVRLLI 183 A+ N +L+ V+ +A+G V+ G G PL +AA G EI+ L+ Sbjct: 9 ALKNGDLDEVKDYVAKGEDVNRTLEG-------------GRKPLHYAADCGQLEILEFLL 55 Query: 184 EHGADIRAQD 193 GADI A D Sbjct: 56 LKGADINAPD 65 >6CUD-A nrPDB Length = 806 Score = 34.7 bits (78), Expect = 0.17, Method: Compositional matrix adjust. Identities = 33/152 (21%), Positives = 63/152 (41%), Gaps = 20/152 (13%) Query: 455 SFALVLGWCSVMYFARGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFHITFQT 514 + A+VL + + Y + GP I + + + D+ +F L +V F I + Sbjct: 531 AIAVVLSFSRIAYILPANESFGPLQISLGRTV-KDIFKFMVLFIMVFFAFMIGMFILYSY 589 Query: 515 EDPNNLGEFSDYPTALFSTFE-----LFLTIIDGPANYSVDLPFMY-------CITYAAF 562 LG + A F+T E LF +I SV L + + + Y + Sbjct: 590 ----YLGAKVN---AAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIY 642 Query: 563 AIIATLLMLNLFIAMMGDTHWRVAQERDELWR 594 + +++LN+ IAM+ ++ + + D W+ Sbjct: 643 NVTMVVVLLNMLIAMINSSYQEIEDDSDVEWK 674 >2DWZ-A nrPDB Length = 231 Score = 34.7 bits (78), Expect = 0.17, Method: Compositional matrix adjust. Identities = 39/143 (27%), Positives = 61/143 (42%), Gaps = 27/143 (18%) Query: 81 TALHVAALYDNLEAATLLME-AAPELAKEPALCEPFVGQTALHIAVMNQNLNLVRALLAR 139 TALH A + E L++ P K+ A G + LHIA +V+ALL + Sbjct: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDA------GWSPLHIAASAGRDEIVKALLVK 95 Query: 140 GASVSARATGA------AFRRSPHNLI--------------YYGEHPLSFAACVGSEEIV 179 GA V+A A ++ H + +Y + AA G+ ++V Sbjct: 96 GAHVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYDATAMHRAAAKGNLKMV 155 Query: 180 RLLIEHGADIRAQDSLGNTVLHI 202 +L+ + A QD+ GNT LH+ Sbjct: 156 HILLFYKASTNIQDTEGNTPLHL 178 Score = 32.7 bits (73), Expect = 0.59, Method: Compositional matrix adjust. Identities = 27/84 (32%), Positives = 37/84 (44%), Gaps = 13/84 (15%) Query: 118 QTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEE 177 +TALH A + +V LL G V+ + G PL AA G +E Sbjct: 41 RTALHWACSAGHTEIVEFLLQLGVPVNDKDDA-------------GWSPLHIAASAGRDE 87 Query: 178 IVRLLIEHGADIRAQDSLGNTVLH 201 IV+ L+ GA + A + G T LH Sbjct: 88 IVKALLVKGAHVNAVNQNGCTPLH 111 Score = 30.8 bits (68), Expect = 2.0, Method: Compositional matrix adjust. Identities = 43/158 (27%), Positives = 61/158 (38%), Gaps = 23/158 (14%) Query: 47 SPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLME--AAPE 104 SPL AA ++K LL+ + G T LH AA + E A +L+E A P+ Sbjct: 75 SPLHIAASAGRDEIVKALLV-KGAHVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133 Query: 105 LAKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGE 164 + TA+H A NL +V LL AS + + T G Sbjct: 134 -------AKDHYDATAMHRAAAKGNLKMVHILLFYKASTNIQDT-------------EGN 173 Query: 165 HPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHI 202 PL A E + L+ GA I ++ T L + Sbjct: 174 TPLHLACDEERVEEAKFLVTQGASIYIENKEEKTPLQV 211 Score = 29.3 bits (64), Expect = 6.5, Method: Compositional matrix adjust. Identities = 28/108 (25%), Positives = 48/108 (44%), Gaps = 8/108 (7%) Query: 36 VNMLQQERIRDSPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAA 95 VN + Q +PL AA +N + ++LL + + TA+H AA NL+ Sbjct: 99 VNAVNQNGC--TPLHYAASKNRHEI-AVMLLEGGANPDAKDHYDATAMHRAAAKGNLKMV 155 Query: 96 TLLMEAAPELAKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASV 143 +L+ K + G T LH+A + + + L+ +GAS+ Sbjct: 156 HILL-----FYKASTNIQDTEGNTPLHLACDEERVEEAKFLVTQGASI 198 >1BD8-A nrPDB Length = 156 Score = 34.3 bits (77), Expect = 0.20, Method: Compositional matrix adjust. Identities = 37/131 (28%), Positives = 57/131 (43%), Gaps = 26/131 (19%) Query: 117 GQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSE 176 G+TAL + +M + + LL +GAS + + T G P+ AA G Sbjct: 36 GKTALQV-MMFGSTAIALELLKQGASPNVQDT-------------SGTSPVHDAARTGFL 81 Query: 177 EIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHSDHLQSLELVP 236 + +++L+EHGAD+ D G +H L +Q T L D H Sbjct: 82 DTLKVLVEHGADVNVPDGTGALPIH-LAVQEGHTAVVSF--LAAESDLHR---------R 129 Query: 237 NHQGLTPFKLA 247 + +GLTP +LA Sbjct: 130 DARGLTPLELA 140 >6BWF-A nrPDB Length = 954 Score = 34.3 bits (77), Expect = 0.20, Method: Compositional matrix adjust. Identities = 34/154 (22%), Positives = 65/154 (42%), Gaps = 23/154 (14%) Query: 458 LVLGWCSVMYFARGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFH-ITFQTED 516 ++ + ++ F Q GP+ +MI KM+ ++ +MA+V+L F I + E+ Sbjct: 623 IIFWYVRLLDFLAVNQQAGPYVMMIGKMV-ANMFYIVVIMALVLLSFGVPRKAILYPHEE 681 Query: 517 PN--------------NLGEFSDYPTALFSTFELFLTIIDGPANYSVDLPFMYCITYAAF 562 P+ GE Y + + TI GP + PF+ A + Sbjct: 682 PSWSLAKDIVFHPYWMIFGEVYAYEIDVCANDSTLPTIC-GPGTWLT--PFLQ----AVY 734 Query: 563 AIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQ 596 + ++M+NL IA + + +V + +W+ Q Sbjct: 735 LFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQ 768 >3ZKJ-A nrPDB Length = 261 Score = 33.9 bits (76), Expect = 0.26, Method: Compositional matrix adjust. Identities = 44/183 (24%), Positives = 76/183 (41%), Gaps = 32/183 (17%) Query: 36 VNMLQQERIRDSPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGE--TALHVAALYDNLE 93 VN++ + + SPL +A L +KILL + + Q G + T L A + + + Sbjct: 29 VNIITADHV--SPLHEACLGGHLSCVKILLKHGA---QVNGVTADWHTPLFNACVSGSWD 83 Query: 94 AATLLMEAAPELAKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSAR------- 146 LL++ + E L P +H A ++ V +L+A G ++ + Sbjct: 84 CVNLLLQHGASVQPESDLASP------IHEAARRGHVECVNSLIAYGGNIDHKISHLGTP 137 Query: 147 ---ATGAAFRRSPHNLIYYG---------EHPLSFAACVGSEEIVRLLIEHGADIRAQDS 194 A R L+ G + PL A SEE+ LL++ GAD +A+++ Sbjct: 138 LYLACENQQRACVKKLLESGADVNQGKGQDSPLHAVARTASEELACLLMDFGADTQAKNA 197 Query: 195 LGN 197 G Sbjct: 198 EGK 200 >6CV9-A nrPDB Length = 842 Score = 33.5 bits (75), Expect = 0.33, Method: Compositional matrix adjust. Identities = 28/148 (18%), Positives = 63/148 (42%), Gaps = 12/148 (8%) Query: 455 SFALVLGWCSVMYFARGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFA-------SA 507 + A+VL + + Y + GP I + + + D+ +F + +V + F S Sbjct: 511 AIAVVLSFSRIAYILPANESFGPLQISLGRTV-KDIFKFMVIFIMVFVAFMIGMFNLYSY 569 Query: 508 FHITFQTEDPNNLGE-FSDYPTALFSTFELFLTIIDGPANYSVDLPFMYCITYAAFAIIA 566 + Q E + E F A+F E+ +I+ + ++ + + Y + + Sbjct: 570 YIGAKQNEAFTTVEESFKTLFWAIFGLSEVKSVVINYNHKFIENIGY---VLYGVYNVTM 626 Query: 567 TLLMLNLFIAMMGDTHWRVAQERDELWR 594 +++LN+ IAM+ + + + D W+ Sbjct: 627 VIVLLNMLIAMINSSFQEIEDDADVEWK 654 >3EHQ-A nrPDB Length = 222 Score = 33.5 bits (75), Expect = 0.34, Method: Compositional matrix adjust. Identities = 35/108 (32%), Positives = 51/108 (47%), Gaps = 8/108 (7%) Query: 40 QQERIRDSPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLM 99 Q E I D+PL +AAK +L L+ L N+ G TAL+ A + + +L Sbjct: 69 QAESI-DNPLHEAAKRGNLSWLRECLDNR-VGVNGLDKAGSTALYWACHGGHKDIVEMLF 126 Query: 100 -EAAPELAKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSAR 146 + EL ++ L G TALH A ++V+ LLA+GA R Sbjct: 127 TQPNIELNQQNKL-----GDTALHAAAWKGYADIVQLLLAKGARTDLR 169 >3DEO-A nrPDB Length = 183 Score = 32.7 bits (73), Expect = 0.52, Method: Compositional matrix adjust. Identities = 19/41 (46%), Positives = 25/41 (60%), Gaps = 1/41 (2%) Query: 163 GEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGN-TVLHI 202 G L F A +GS++ VRLL E GAD+ +D G T LH+ Sbjct: 76 GRTALLFVAGLGSDKCVRLLAEAGADLDHRDMRGGLTALHM 116 >3UI2-A nrPDB Length = 244 Score = 32.7 bits (73), Expect = 0.61, Method: Compositional matrix adjust. Identities = 19/41 (46%), Positives = 25/41 (60%), Gaps = 1/41 (2%) Query: 163 GEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGN-TVLHI 202 G L F A +GS++ VRLL E GAD+ +D G T LH+ Sbjct: 77 GRTALLFVAGLGSDKCVRLLAEAGADLDHRDMRGGLTALHM 117 >5MKE-A nrPDB Length = 968 Score = 32.0 bits (71), Expect = 0.91, Method: Compositional matrix adjust. Identities = 26/108 (24%), Positives = 52/108 (48%), Gaps = 9/108 (8%) Query: 489 DLMRFCWLMAVVILGFASAFHITFQTEDPNNLGEFSDYPTALFSTFELFLTIIDGPANYS 548 DL F + ++ L +A ++ F T+ + +FS + +F+ F + L I+ A Sbjct: 596 DLFGFAIMFFIIFLAYAQLAYLVFGTQ----VDDFSTFQECIFTQFRIILGDINF-AEIE 650 Query: 549 VDLPFMYCITYAAFAIIATLLMLNLFIAMMGDTHWRV----AQERDEL 592 + I + F ++LN+F+A++ DT+ V AQ++ E+ Sbjct: 651 EANRVLGPIYFTTFVFFMFFILLNMFLAIINDTYSEVKSDLAQQKAEM 698 >5UQE-A nrPDB Length = 520 Score = 32.0 bits (71), Expect = 0.93, Method: Compositional matrix adjust. Identities = 21/53 (39%), Positives = 29/53 (54%), Gaps = 1/53 (1%) Query: 49 LLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEA 101 LL AA D+ L+ L+ + D +QR TALHVAA ++E L+EA Sbjct: 421 LLFAAYTGDVSALRRFALS-AMDMEQRDYDSRTALHVAAAEGHVEVVKFLLEA 472 >1G3N-B nrPDB Length = 168 Score = 31.6 bits (70), Expect = 1.1, Method: Compositional matrix adjust. Identities = 18/51 (35%), Positives = 29/51 (56%) Query: 48 PLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLL 98 PL AAKE LR+++ L+ + + + R G+TA +A LY E +L+ Sbjct: 106 PLHLAAKEGHLRVVEFLVKHTASNVGHRNHKGDTACDLARLYGRNEVVSLM 156 >5U0J-A nrPDB Length = 140 Score = 31.6 bits (70), Expect = 1.2, Method: Compositional matrix adjust. Identities = 21/53 (39%), Positives = 29/53 (54%), Gaps = 1/53 (1%) Query: 49 LLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEA 101 LL AA D+ L+ L+ + D +QR TALHVAA ++E L+EA Sbjct: 28 LLFAAYTGDVSALRRFALS-AMDMEQRDYDSRTALHVAAAEGHVEVVKFLLEA 79 >1DCQ-A nrPDB Length = 278 Score = 30.8 bits (68), Expect = 2.0, Method: Compositional matrix adjust. Identities = 22/62 (35%), Positives = 31/62 (50%), Gaps = 9/62 (14%) Query: 65 LLNQSCDFQQRGAVGETALHVAALYDNLEAATLLM--EAAPELAKEPALCEPFVGQTALH 122 L+ S + ++ G TALH L DN E LL+ +A+ E+A E G+T L Sbjct: 191 LVQNSGNLDKQTGKGSTALHYCCLTDNAECLKLLLRGKASIEIANES-------GETPLD 243 Query: 123 IA 124 IA Sbjct: 244 IA 245 >6BPQ-A nrPDB Length = 950 Score = 30.8 bits (68), Expect = 2.3, Method: Compositional matrix adjust. Identities = 37/146 (25%), Positives = 60/146 (41%), Gaps = 25/146 (17%) Query: 475 LGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFHITFQTEDPN------------NLGE 522 LGP IM+Q+M+ D+ F +L AV ++ F A + + L Sbjct: 727 LGPKIIMLQRMMI-DVFFFLFLFAVWMVAFGVARQGILRKNEHRWEWIFRSVIYEPYLAM 785 Query: 523 FSDYPTAL-----------FSTFELFLTIIDGPANYSVDLPFMYCITYAAFAIIAT-LLM 570 F YP + FS E ++ AN P I +++T +L+ Sbjct: 786 FGQYPDDIDGTTYNFDHCTFSGNESKPLCVELDANNQPRFPEWITIPLVCIYMLSTNILL 845 Query: 571 LNLFIAMMGDTHWRVAQERDELWRAQ 596 +NL +AM G T V + D++W+ Q Sbjct: 846 VNLLVAMFGYTVGSVQENNDQVWKFQ 871 >6DU8-A nrPDB Length = 805 Score = 30.8 bits (68), Expect = 2.4, Method: Compositional matrix adjust. Identities = 25/108 (23%), Positives = 51/108 (47%), Gaps = 9/108 (8%) Query: 489 DLMRFCWLMAVVILGFASAFHITFQTEDPNNLGEFSDYPTALFSTFELFLTIIDGPANYS 548 D++ F + +V +A ++ F T+ N FS + +F+ F + L D A + Sbjct: 476 DILGFAVMFFIVFFAYAQLGYLLFGTQVEN----FSTFIKCIFTQFRIILGDFDYNAIDN 531 Query: 549 VDLPFMYCITYAAFAIIATLLMLNLFIAMMGDTHWRVAQE----RDEL 592 + + + + ++LN+F+A++ DT+ V +E +DEL Sbjct: 532 ANR-ILGPAYFVTYVFFVFFVLLNMFLAIINDTYSEVKEELAGQKDEL 578 >3CO4-A nrPDB Length = 312 Score = 30.4 bits (67), Expect = 2.6, Method: Compositional matrix adjust. Identities = 18/70 (25%), Positives = 36/70 (51%), Gaps = 4/70 (5%) Query: 28 DWEQYRDRVNMLQQER--IRDSPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHV 85 +WEQY D +N++ +R D P+ A+ ++ ++ LK N+ C + VG + Sbjct: 157 EWEQYFDYINLMSYDRGAFTDKPVQHASYDDFVKDLK--YWNEQCRASKSKIVGGLPFYG 214 Query: 86 AALYDNLEAA 95 + ++L+ A Sbjct: 215 YSWEESLQGA 224 >6EMK-G nrPDB Length = 426 Score = 30.4 bits (67), Expect = 2.7, Method: Compositional matrix adjust. Identities = 41/168 (24%), Positives = 73/168 (43%), Gaps = 19/168 (11%) Query: 38 MLQQERIRDSPLLQAAKENDLRLLKILLL-NQSCDFQQRGAVGETALHVAALYDNLEAAT 96 ML++ +R L +A E +L ++K LL N G ++LH A+ + Sbjct: 1 MLKEPSVR---LREAIIEGNLLIVKRLLRRNPDLLTNIDSENGWSSLHYASYHGRYLICV 57 Query: 97 LLMEAAPELAKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSP 156 L++ + + L + F G T +H+A+M + + LL + F R Sbjct: 58 YLIQLGHDKHE---LIKTFKGNTCVHLALMKGHEQTLHLLLQQ------------FPRFI 102 Query: 157 HNLIYYGEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILI 204 ++ G P+ A + + LLI GAD+ D+ G+T LH+ + Sbjct: 103 NHRGENGRAPIHIACMNDYYQCLSLLIGVGADLWVMDTNGDTPLHVCL 150 >5U0K-A nrPDB Length = 141 Score = 30.4 bits (67), Expect = 2.8, Method: Compositional matrix adjust. Identities = 29/92 (31%), Positives = 41/92 (44%), Gaps = 13/92 (14%) Query: 49 LLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELAKE 108 LL AA D+ L+ L+ + D +Q+ TALHVAA ++E L+EA Sbjct: 29 LLFAAYSGDVSALRRFALS-AMDMEQKDYDSRTALHVAAAEGHIEVVKFLIEACK----- 82 Query: 109 PALCEPFV----GQTALHIAVMNQNLNLVRAL 136 PF G L AV +L +V+ L Sbjct: 83 ---VNPFAKDRWGNIPLDDAVQFNHLEVVKLL 111 >4BSZ-B nrPDB Length = 202 Score = 30.0 bits (66), Expect = 3.7, Method: Composition-based stats. Identities = 21/62 (33%), Positives = 31/62 (50%), Gaps = 7/62 (11%) Query: 81 TALHVAALYDNLEAATLLMEAAPELAKEPALCEPFV------GQTALHIAVMNQNLNLVR 134 TALH+AA ++E ++E A + FV G TALH A +N L++V+ Sbjct: 54 TALHMAAANGHIETVRYILETVSR-ANSAEDLKAFVNEVNKTGNTALHWASLNGKLDVVK 112 Query: 135 AL 136 L Sbjct: 113 LL 114 >5UIL-A nrPDB Length = 405 Score = 30.0 bits (66), Expect = 3.9, Method: Compositional matrix adjust. Identities = 14/38 (36%), Positives = 23/38 (60%) Query: 162 YGEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTV 199 YG P+ AA G+ E+++ L+ GA+I ++ G TV Sbjct: 310 YGWSPVIVAAYHGNIELIKWLVSKGANINDRNYKGTTV 347 >6D1W-A nrPDB Length = 740 Score = 30.0 bits (66), Expect = 3.9, Method: Compositional matrix adjust. Identities = 26/108 (24%), Positives = 52/108 (48%), Gaps = 9/108 (8%) Query: 489 DLMRFCWLMAVVILGFASAFHITFQTEDPNNLGEFSDYPTALFSTFELFLTIIDGPANYS 548 DL F + ++ L +A ++ F T+ + +FS + +F+ F + L I+ A Sbjct: 544 DLFGFAIMPFIIFLAYAQLAYLVFGTQ----VDDFSTFQECIFTQFRIILGDINF-AEIE 598 Query: 549 VDLPFMYCITYAAFAIIATLLMLNLFIAMMGDTHWRV----AQERDEL 592 + I + F ++LN+F+A++ DT+ V AQ++ E+ Sbjct: 599 EANRVLGPIYFTTFVFFMFFILLNMFLAIINDTYSEVKSDLAQQKAEM 646 >6AYG-A nrPDB Length = 558 Score = 30.0 bits (66), Expect = 4.2, Method: Compositional matrix adjust. Identities = 33/157 (21%), Positives = 70/157 (44%), Gaps = 18/157 (11%) Query: 444 LTNMNGEVVPLSFALVLGWCSVMYFARGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILG 503 LT+ + + L + +L W V+ + F + +Q + +++RFC A++ LG Sbjct: 372 LTSYDVCSILLGTSTMLVWLGVIRYLGFFAKYNLLILTLQAAL-PNVIRFCCCAAMIYLG 430 Query: 504 FASAFHITFQTEDPNNLGEFSDYPTALFSTFELFLTIIDGPANYSV--------DLPFMY 555 + I LG + D +L E ++I+G ++ L +++ Sbjct: 431 YCFCGWIV--------LGPYHDKFRSLNMVSECLFSLINGDDMFATFAKMQQKSYLVWLF 482 Query: 556 CITY-AAFAIIATLLMLNLFIAMMGDTHWRVAQERDE 591 Y +F + ++L+LFIA++ DT+ + Q + + Sbjct: 483 SRIYLYSFISLFIYMILSLFIALITDTYETIKQYQQD 519 >3T9K-A nrPDB Length = 390 Score = 29.3 bits (64), Expect = 6.8, Method: Compositional matrix adjust. Identities = 25/98 (25%), Positives = 42/98 (42%), Gaps = 6/98 (6%) Query: 36 VNMLQQERIRDSPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAA 95 VN + + +PL+QA N L + LL N + Q + G LH A + + A Sbjct: 226 VNWVNGGQDNATPLIQATAANSLLACEFLLQN-GANVNQADSAGRGPLHHATILGHTGLA 284 Query: 96 TLLMEAAPELAKEPALCEPFVGQTALHIAVMNQNLNLV 133 L ++ +L + G+ L IA+ N ++V Sbjct: 285 CLFLKRGADLGARDS-----EGRDPLTIAMETANADIV 317 >5T4D-A nrPDB Length = 510 Score = 28.9 bits (63), Expect = 7.3, Method: Compositional matrix adjust. Identities = 29/115 (25%), Positives = 54/115 (46%), Gaps = 23/115 (20%) Query: 489 DLMRFCWLMAVVILGFASAFHITFQTEDPNNLGEFSDYPTALFSTFELFLTIIDGPANYS 548 DL F + ++ L +A ++ F T+ + +FS + +F+ F II G N++ Sbjct: 404 DLFGFAIMFFIIFLAYAQLAYLVFGTQ----VDDFSTFQECIFTQFR----IILGDINFA 455 Query: 549 -------VDLPFMYCITYAAFAIIATLLMLNLFIAMMGDTHWRV----AQERDEL 592 V P I + F ++LN+F+A++ DT+ V AQ++ E+ Sbjct: 456 EIEEANRVLGP----IYFTTFVFFMFFILLNMFLAIINDTYSEVKSDLAQQKAEM 506 >5D68-A nrPDB Length = 486 Score = 28.9 bits (63), Expect = 7.4, Method: Compositional matrix adjust. Identities = 39/164 (23%), Positives = 59/164 (35%), Gaps = 52/164 (31%) Query: 40 QQERIRDSPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLM 99 +++ + D PL ++A E D LL LL++ Q + +H A Y +EA +L+ Sbjct: 33 ERQWVDDFPLHRSACEGDSELLS-RLLSERFSVNQLDSDHWAPIHYACWYGKVEATRILL 91 Query: 100 EAAPELAKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNL 159 E C P NL+ L+ Sbjct: 92 EKGK--------CNP----------------NLLNGQLSS-------------------- 107 Query: 160 IYYGEHPLSFAACVGSEEIVRLLIEH-GADIRAQDSLGNTVLHI 202 PL FAA G EIV++L+ H D D G + L+I Sbjct: 108 ------PLHFAAGGGHAEIVQILLNHPETDRHITDQQGRSPLNI 145 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 6DMR-A nrPDB 1056 0.0 6BOA-A nrPDB 1002 0.0 6E2G-A nrPDB 994 0.0 6BBJ-A nrPDB 608 e-174 6C8G-A nrPDB 600 e-172 6DVZ-A nrPDB 595 e-170 5IRX-A nrPDB 594 e-170 6MHW-A nrPDB 580 e-166 6OO7-A nrPDB 548 e-156 5AN8-A nrPDB 541 e-154 5HI9-A nrPDB 531 e-151 6BO5-A nrPDB 526 e-149 2RFA-A nrPDB 288 7e-78 2ETB-A nrPDB 223 3e-58 2F37-A nrPDB 221 7e-58 3W9G-A nrPDB 197 1e-50 4DX2-A nrPDB 196 2e-50 5H76-A nrPDB 195 5e-50 6MWQ-A nrPDB 195 6e-50 5AQ9-A nrPDB 193 2e-49 4N5Q-A nrPDB 193 4e-49 5AQA-A nrPDB 192 5e-49 5MIO-C nrPDB 189 4e-48 2NYJ-A nrPDB 187 1e-47 5AQB-A nrPDB 187 1e-47 5AQ7-A nrPDB 186 2e-47 4OAU-C nrPDB 184 1e-46 6FES-A nrPDB 179 3e-45 6G1K-A nrPDB 175 6e-44 3B7B-A nrPDB 173 2e-43 6AUN-A nrPDB 167 2e-41 5Z96-A nrPDB 162 5e-40 4Z68-A nrPDB 161 9e-40 5GP7-A nrPDB 158 9e-39 5CBO-A nrPDB 132 7e-31 5OEO-C nrPDB 95 9e-20 4OT9-A nrPDB 94 3e-19 Sequences not found previously or not previously below threshold: 6BY9-A nrPDB 172 5e-43 4O1O-A nrPDB 150 2e-36 5JHQ-A nrPDB 141 1e-33 5HKP-A nrPDB 139 4e-33 2DWZ-A nrPDB 116 3e-26 4NIK-A nrPDB 116 4e-26 5ET1-A nrPDB 105 7e-23 3EU9-A nrPDB 101 1e-21 3ZKJ-A nrPDB 96 4e-20 6CUD-A nrPDB 94 2e-19 1BD8-A nrPDB 91 2e-18 1WG0-A nrPDB 90 4e-18 6CV9-A nrPDB 86 5e-17 1BLX-B nrPDB 83 4e-16 3LJN-A nrPDB 77 2e-14 1G3N-B nrPDB 70 3e-12 5DND-A nrPDB 69 7e-12 6EMK-G nrPDB 68 1e-11 2KXP-C nrPDB 68 2e-11 3T9K-A nrPDB 67 3e-11 5D68-A nrPDB 66 6e-11 3UI2-A nrPDB 66 6e-11 3EHQ-A nrPDB 66 8e-11 3DEO-A nrPDB 65 9e-11 1D9S-A nrPDB 60 5e-09 6BWF-A nrPDB 57 2e-08 6DJS-A nrPDB 57 3e-08 4BSZ-B nrPDB 56 4e-08 5U0K-A nrPDB 54 3e-07 6BPQ-A nrPDB 52 6e-07 1DCQ-A nrPDB 51 2e-06 5UQE-A nrPDB 50 3e-06 5U0J-A nrPDB 50 3e-06 2A5E-A nrPDB 50 3e-06 5Z1W-A nrPDB 45 9e-05 3LVQ-E nrPDB 45 1e-04 2B0O-E nrPDB 45 1e-04 6DU8-A nrPDB 45 1e-04 5UIL-A nrPDB 42 8e-04 5MKE-A nrPDB 41 0.002 5EK0-A nrPDB 41 0.002 5T4D-A nrPDB 41 0.002 5WPT-A nrPDB 41 0.002 6E7Z-A nrPDB 39 0.009 4DXW-A nrPDB 39 0.010 6D1W-A nrPDB 39 0.010 3RVY-A nrPDB 39 0.010 6AYG-A nrPDB 37 0.020 4XD0-A nrPDB 37 0.023 6BWI-A nrPDB 35 0.089 4GX0-A nrPDB 35 0.14 6N4I-A nrPDB 35 0.17 5E1J-A nrPDB 33 0.51 2GBW-A nrPDB 32 1.1 3G2F-A nrPDB 31 2.4 2FT0-A nrPDB 30 3.3 3CO4-A nrPDB 30 3.3 2N4X-A nrPDB 29 7.2 >6DMR-A nrPDB Length = 730 Score = 1056 bits (2731), Expect = 0.0, Method: Composition-based stats. Identities = 730/730 (100%), Positives = 730/730 (100%) Query: 1 MGACPPKAKGPWAQLQKLLISWPVGEQDWEQYRDRVNMLQQERIRDSPLLQAAKENDLRL 60 MGACPPKAKGPWAQLQKLLISWPVGEQDWEQYRDRVNMLQQERIRDSPLLQAAKENDLRL Sbjct: 1 MGACPPKAKGPWAQLQKLLISWPVGEQDWEQYRDRVNMLQQERIRDSPLLQAAKENDLRL 60 Query: 61 LKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELAKEPALCEPFVGQTA 120 LKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELAKEPALCEPFVGQTA Sbjct: 61 LKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELAKEPALCEPFVGQTA 120 Query: 121 LHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVR 180 LHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVR Sbjct: 121 LHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVR 180 Query: 181 LLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHSDHLQSLELVPNHQG 240 LLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHSDHLQSLELVPNHQG Sbjct: 181 LLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHSDHLQSLELVPNHQG 240 Query: 241 LTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLTSTLYDLTEIDSWGEELSFLELVVSSK 300 LTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLTSTLYDLTEIDSWGEELSFLELVVSSK Sbjct: 241 LTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLTSTLYDLTEIDSWGEELSFLELVVSSK 300 Query: 301 KREARQILEQTPVKELVSFKWKKYGRPYFCVLASLYILYMICFTTCCIYRPLKLRDDNRT 360 KREARQILEQTPVKELVSFKWKKYGRPYFCVLASLYILYMICFTTCCIYRPLKLRDDNRT Sbjct: 301 KREARQILEQTPVKELVSFKWKKYGRPYFCVLASLYILYMICFTTCCIYRPLKLRDDNRT 360 Query: 361 DPRDITILQQKLLQEAYVTHQDNIRLVGELVTVTGAVIILLLEIPDIFRVGASRYFGQTI 420 DPRDITILQQKLLQEAYVTHQDNIRLVGELVTVTGAVIILLLEIPDIFRVGASRYFGQTI Sbjct: 361 DPRDITILQQKLLQEAYVTHQDNIRLVGELVTVTGAVIILLLEIPDIFRVGASRYFGQTI 420 Query: 421 LGGPFHVIIITYASLVLLTMVMRLTNMNGEVVPLSFALVLGWCSVMYFARGFQMLGPFTI 480 LGGPFHVIIITYASLVLLTMVMRLTNMNGEVVPLSFALVLGWCSVMYFARGFQMLGPFTI Sbjct: 421 LGGPFHVIIITYASLVLLTMVMRLTNMNGEVVPLSFALVLGWCSVMYFARGFQMLGPFTI 480 Query: 481 MIQKMIFGDLMRFCWLMAVVILGFASAFHITFQTEDPNNLGEFSDYPTALFSTFELFLTI 540 MIQKMIFGDLMRFCWLMAVVILGFASAFHITFQTEDPNNLGEFSDYPTALFSTFELFLTI Sbjct: 481 MIQKMIFGDLMRFCWLMAVVILGFASAFHITFQTEDPNNLGEFSDYPTALFSTFELFLTI 540 Query: 541 IDGPANYSVDLPFMYCITYAAFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVAT 600 IDGPANYSVDLPFMYCITYAAFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVAT Sbjct: 541 IDGPANYSVDLPFMYCITYAAFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVAT 600 Query: 601 TVMLERKMPRFLWPRSGICGYEYGLGDRWFLRVENHHDQNPLRVLRYVEAFKCSDKEDGQ 660 TVMLERKMPRFLWPRSGICGYEYGLGDRWFLRVENHHDQNPLRVLRYVEAFKCSDKEDGQ Sbjct: 601 TVMLERKMPRFLWPRSGICGYEYGLGDRWFLRVENHHDQNPLRVLRYVEAFKCSDKEDGQ 660 Query: 661 EQLSEKRPSTVESGMLSRASVAFQTPSLSRTTSQSSNSHRGWEILRRNTLGHLNLGLDLG 720 EQLSEKRPSTVESGMLSRASVAFQTPSLSRTTSQSSNSHRGWEILRRNTLGHLNLGLDLG Sbjct: 661 EQLSEKRPSTVESGMLSRASVAFQTPSLSRTTSQSSNSHRGWEILRRNTLGHLNLGLDLG 720 Query: 721 EGDGEEVYHF 730 EGDGEEVYHF Sbjct: 721 EGDGEEVYHF 730 >6BOA-A nrPDB Length = 742 Score = 1002 bits (2590), Expect = 0.0, Method: Composition-based stats. Identities = 538/727 (74%), Positives = 602/727 (82%), Gaps = 12/727 (1%) Query: 1 MGACPPKAKGPWAQLQKLLISWPVGEQDWEQYRDRVNMLQQERIRDSPLLQAAKENDLRL 60 MG PK KG L W + W Q RD N+LQQ+RI +SPLL AAK+ND++ Sbjct: 1 MGLSLPKEKGLILCLWSKFCRWFQRRESWAQSRDEQNLLQQKRIWESPLLLAAKDNDVQA 60 Query: 61 LKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELAKEPALCEPFVGQTA 120 L LL + C QRGA+GETALH+AALYDNLEAA +LMEAAPEL EP E + GQTA Sbjct: 61 LNKLLKYEDCKVHQRGAMGETALHIAALYDNLEAAMVLMEAAPELVFEPMTSELYEGQTA 120 Query: 121 LHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVR 180 LHIAV+NQN+NLVRALLAR ASVSARATG AFRRSP NLIY+GEHPLSFAACV SEEIVR Sbjct: 121 LHIAVVNQNMNLVRALLARRASVSARATGTAFRRSPCNLIYFGEHPLSFAACVNSEEIVR 180 Query: 181 LLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHSDHLQSLELVPNHQG 240 LLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYD H DHLQ L+LVPNHQG Sbjct: 181 LLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDRHGDHLQPLDLVPNHQG 240 Query: 241 LTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLTSTLYDLTEIDSWGEELSFLELVVSSK 300 LTPFKLAGVEGNTVMFQHLMQKRKH QWT GPLTSTLYDLTEIDS G+E S LEL++++K Sbjct: 241 LTPFKLAGVEGNTVMFQHLMQKRKHTQWTYGPLTSTLYDLTEIDSSGDEQSLLELIITTK 300 Query: 301 KREARQILEQTPVKELVSFKWKKYGRPYFCVLASLYILYMICFTTCCIYRPLKLRDDNRT 360 KREARQIL+QTPVKELVS KWK+YGRPYFC+L ++Y+LY+ICFT CCIYRPLK R +NRT Sbjct: 301 KREARQILDQTPVKELVSLKWKRYGRPYFCMLGAIYLLYIICFTMCCIYRPLKPRTNNRT 360 Query: 361 DPRDITILQQKLLQEAYVTHQDNIRLVGELVTVTGAVIILLLEIPDIFRVGASRYFGQTI 420 PRD T+LQQKLLQEAY+T +D+IRLVGELVTV GA+IILL+E+PDIFR+G +R+FGQTI Sbjct: 361 SPRDNTLLQQKLLQEAYMTPKDDIRLVGELVTVIGAIIILLVEVPDIFRMGVTRFFGQTI 420 Query: 421 LGGPFHVIIITYASLVLLTMVMRLTNMNGEVVPLSFALVLGWCSVMYFARGFQMLGPFTI 480 LGGPFHV+IITYA +VL+TMVMRL + +GEVVP+SFALVLGWC+VMYFA GFQMLGPFTI Sbjct: 421 LGGPFHVLIITYAFMVLVTMVMRLISASGEVVPMSFALVLGWCNVMYFAEGFQMLGPFTI 480 Query: 481 MIQKMIFGDLMRFCWLMAVVILGFASAFHITFQTEDPNNLGEFSDYPTALFSTFELFLTI 540 MIQKMIFGDLMRFCWLMAVVILGFASAF+I FQTEDP LG F DYP ALFSTFELFLTI Sbjct: 481 MIQKMIFGDLMRFCWLMAVVILGFASAFYIIFQTEDPEELGHFYDYPMALFSTFELFLTI 540 Query: 541 IDGPANYSVDLPFMYCITYAAFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVAT 600 IDGPANY+VDLPFMY ITYAAFAIIATLLMLNL IAMMGDTHWRVA ERDELWRAQ+VAT Sbjct: 541 IDGPANYNVDLPFMYSITYAAFAIIATLLMLNLLIAMMGDTHWRVAHERDELWRAQIVAT 600 Query: 601 TVMLERKMPRFLWPRSGICGYEYGLGDRWFLRVENHHDQNPLRVLRYVEAFKCSDKEDGQ 660 TVMLERK+PR LWPRSGICG EYGLGDRWFLRVE+ D N R+ RY +AF ED Sbjct: 601 TVMLERKLPRCLWPRSGICGREYGLGDRWFLRVEDRQDLNRQRIQRYAQAFHTRGSEDLD 660 Query: 661 EQLSEKRPSTVESGMLSRASVAFQTPSLSRTTSQSSNSHRGWEILRRNTL-----GHLNL 715 + EK +E G ++ PS+SR+TS+SS + WE LR+ TL G +N Sbjct: 661 KDSVEK----LELGCPFSPHLSLPMPSVSRSTSRSSAN---WERLRQGTLRRDLRGIINR 713 Query: 716 GLDLGEG 722 GL+ GE Sbjct: 714 GLEDGES 720 >6E2G-A nrPDB Length = 727 Score = 994 bits (2571), Expect = 0.0, Method: Composition-based stats. Identities = 541/734 (73%), Positives = 610/734 (83%), Gaps = 24/734 (3%) Query: 1 MGACPPKAKGPWAQLQKLLISWPVGEQDWEQYRDRVNMLQQERIRDSPLLQAAKENDLRL 60 MG PK KG L W + W Q RD N+LQQ+RI +SPLL AAKEN+++ Sbjct: 1 MGWSLPKEKGLILCLWNKFCRWFHRRESWAQSRDEQNLLQQKRIWESPLLLAAKENNVQA 60 Query: 61 LKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELAKEPALCEPFVGQTA 120 L LL + C+ Q+GA+GETALH+AALYDNLEAA +LMEAAPEL EP E + GQTA Sbjct: 61 LIKLLKFEGCEVHQKGAMGETALHIAALYDNLEAAMVLMEAAPELVFEPMTSELYEGQTA 120 Query: 121 LHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVR 180 LHIAV+NQN+NLVRALLARGASVSARATG+ F PHNLIYYGEHPLSFAACVGSEEIVR Sbjct: 121 LHIAVINQNVNLVRALLARGASVSARATGSVFHYRPHNLIYYGEHPLSFAACVGSEEIVR 180 Query: 181 LLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHSDHLQSLELVPNHQG 240 LLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYD DHL+SLELVPN+QG Sbjct: 181 LLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDG-GDHLKSLELVPNNQG 239 Query: 241 LTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLTSTLYDLTEIDSWGEELSFLELVVSSK 300 LTPFKLAGVEGN VMFQHLMQKRKH+QWT GPLTSTLYDLTEIDS G++ S LEL+V++K Sbjct: 240 LTPFKLAGVEGNIVMFQHLMQKRKHIQWTYGPLTSTLYDLTEIDSSGDDQSLLELIVTTK 299 Query: 301 KREARQILEQTPVKELVSFKWKKYGRPYFCVLASLYILYMICFTTCCIYRPLKLRDDNRT 360 KREARQIL+QTPVKELVS KWK+YGRPYFCVL ++Y+LY+ICFT CC+YRPLK R NRT Sbjct: 300 KREARQILDQTPVKELVSLKWKRYGRPYFCVLGAIYVLYIICFTMCCVYRPLKPRITNRT 359 Query: 361 DPRDITILQQKLLQEAYVTHQDNIRLVGELVTVTGAVIILLLEIPDIFRVGASRYFGQTI 420 +PRD T+LQQKLLQEAYVT +D++RLVGELV++ GAVIILL+EIPDIFR+G +R+FGQTI Sbjct: 360 NPRDNTLLQQKLLQEAYVTPKDDLRLVGELVSIVGAVIILLVEIPDIFRLGVTRFFGQTI 419 Query: 421 LGGPFHVIIITYASLVLLTMVMRLTNMNGEVVPLSFALVLGWCSVMYFARGFQMLGPFTI 480 LGGPFHVII+TYA +VL+TMVMRLTN +GEVVP+SFALVLGWC+VMYFARGFQMLGPFTI Sbjct: 420 LGGPFHVIIVTYAFMVLVTMVMRLTNSDGEVVPMSFALVLGWCNVMYFARGFQMLGPFTI 479 Query: 481 MIQKMIFGDLMRFCWLMAVVILGFASAFHITFQTEDPNNLGEFSDYPTALFSTFELFLTI 540 MIQKMIFGDLMRFCWLMAVVILGFASAF+I FQTEDP+ LG F DYP ALFSTFELFLTI Sbjct: 480 MIQKMIFGDLMRFCWLMAVVILGFASAFYIIFQTEDPDELGHFYDYPMALFSTFELFLTI 539 Query: 541 IDGPANYSVDLPFMYCITYAAFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVAT 600 IDGPANY VDLPFMY ITYAAFAIIATLLMLNL IAMMGDTHWRVA ERDELWRAQVVAT Sbjct: 540 IDGPANYDVDLPFMYSITYAAFAIIATLLMLNLLIAMMGDTHWRVAHERDELWRAQVVAT 599 Query: 601 TVMLERKMPRFLWPRSGICGYEYGLGDRWFLRVENHHDQNPLRVLRYVEAFKCSD----- 655 TVMLERK+PR LWPRSGICG EYGLGDRWFLRVE+ D N R+ RY +AF+ D Sbjct: 600 TVMLERKLPRCLWPRSGICGREYGLGDRWFLRVEDRQDLNRQRIRRYAQAFQQQDDLYSE 659 Query: 656 --KEDGQEQLSEKRPSTVESGMLSRASVAFQTPSLSRTTSQSSNSHRGWEILRRNTL--- 710 ++D E+L RP A ++F TPS+SR+TS+SS + W+ LR+ L Sbjct: 660 DLEKDSGEKLEMARPFG--------AYLSFPTPSVSRSTSRSSTN---WDRLRQGALRKD 708 Query: 711 --GHLNLGLDLGEG 722 G +N GL+ GEG Sbjct: 709 LQGIINRGLEDGEG 722 >6BBJ-A nrPDB Length = 868 Score = 608 bits (1568), Expect = e-174, Method: Composition-based stats. Identities = 192/624 (30%), Positives = 306/624 (49%), Gaps = 81/624 (12%) Query: 77 AVGETALHVAALY---DNLEAATLLME------AAPELAKEPALCEPFVGQTALHIAVMN 127 + G+T L A + + +L++ E P + GQTALHIA+ Sbjct: 185 STGKTCLTKALMNLNGGKNDTIPMLIDIAEKTGNLREFINSPFRDVYYRGQTALHIAIER 244 Query: 128 QNLNLVRALLARGASVSARATGAAFR-RSPHNLIYYGEHPLSFAACVGSEEIVRLLIEHG 186 + + V L+ +GA V A+A G F+ + Y+GE PLS AAC +IV L E+ Sbjct: 245 RCKHYVELLVEKGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTNQPDIVHYLTENA 304 Query: 187 ---ADIRAQDSLGNTVLHILI-----LQPNKTFACQMYNLLLSYDEHSDHLQSLELVPNH 238 ADIR QDS GNTVLH L+ + N F ++Y+LL+ SLE + N+ Sbjct: 305 HKKADIRRQDSRGNTVLHALVAIADNTRENTKFVTKVYDLLVIKCVKLYPDSSLEAIFNN 364 Query: 239 QGLTPFKLAGVEGNTVMFQHLMQ-----------KRKHVQWTCGPLTSTLYDLTEIDSWG 287 ++P +A G +FQH+++ RK W GP+ S+LYDL+ +D+ G Sbjct: 365 DSMSPLMMAAKLGKIGIFQHIIRLEIKDEEARHLSRKFRDWAYGPVYSSLYDLSMLDTCG 424 Query: 288 EELSFLELVVSSKKREAR-QILEQTPVKELVSFKWKKYGRPYFCVLASLYILYMICFTTC 346 EE+S LE++V + K E R ++L P+ EL+ KW+K+G F + Y++ MI FT Sbjct: 425 EEVSVLEILVYNSKVENRHEMLAVEPINELLRDKWQKFGAVSFYISVVSYLIAMIIFTLI 484 Query: 347 CIYRPLKLRDDNRTDPRDITILQQKLLQEAYVTHQDNIRLVGELVTVTGAVIILLLEIPD 406 YRP+ + T P Y T D +RL GE+VT+ V+ + I D Sbjct: 485 AYYRPM-----DGTPPY------------PYRTTMDYMRLAGEIVTLLTGVVFFITNIKD 527 Query: 407 IFRV---GASRYFGQTILGGPFHVIIITYASLVLLTMVMRLTNMNGEVVPLSFALVLGWC 463 +F G + F + G F ++ Y+ LV++T V+ L + + + FALVLGW Sbjct: 528 LFMKKCPGVNSLF----IDGSFQLLYFIYSVLVIITAVLYLVGIESYLAVMVFALVLGWM 583 Query: 464 SVMYFARGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAF----------HITFQ 513 + +YF RG ++ G ++IM+QK++F DL RF + + ++G+ASA + Sbjct: 584 NALYFTRGLKLTGTYSIMLQKILFKDLFRFLLVYLLFMIGYASALVSLLNPCTSQESCIE 643 Query: 514 TEDPNNLGEFSD------YPTALFSTFELFLTIIDGPANYSVDLPFMYCITYAAFAIIAT 567 T + E+ + L F+L + + D S P ++ I + I+ Sbjct: 644 TSSNCTVPEYPSCRDSSTFSKFLLDLFKLTIGMGDLEMINSAKYPAVFIILLVTYIILTF 703 Query: 568 LLMLNLFIAMMGDTHWRVAQERDELWRAQVVATTVMLERKMPRFLWP--RSG----ICGY 621 +L+LN+ IA+MG+T +V++E ++W+ Q T + +ER P + RSG + Sbjct: 704 VLLLNMLIALMGETVGQVSKESKQIWKLQWATTILDIERSFPVCMRKAFRSGEMVTVGKN 763 Query: 622 EYGLGD-RWFLRVE----NHHDQN 640 G D RW RV+ +H +QN Sbjct: 764 LDGTPDRRWCFRVDEVNWSHWNQN 787 >6C8G-A nrPDB Length = 675 Score = 600 bits (1547), Expect = e-172, Method: Composition-based stats. Identities = 192/624 (30%), Positives = 306/624 (49%), Gaps = 81/624 (12%) Query: 77 AVGETALHVAALY---DNLEAATLLME------AAPELAKEPALCEPFVGQTALHIAVMN 127 + G+T L A + + +L++ E P + GQTALHIA+ Sbjct: 54 STGKTCLTKALMNLNGGKNDTIPMLIDIAEKTGNLREFINSPFRDVYYRGQTALHIAIER 113 Query: 128 QNLNLVRALLARGASVSARATGAAFR-RSPHNLIYYGEHPLSFAACVGSEEIVRLLIEHG 186 + + V L+ +GA V A+A G F+ + Y+GE PLS AAC +IV L E+ Sbjct: 114 RCKHYVELLVEKGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTNQPDIVHYLTENA 173 Query: 187 ---ADIRAQDSLGNTVLHILI-----LQPNKTFACQMYNLLLSYDEHSDHLQSLELVPNH 238 ADIR QDS GNTVLH L+ + N F ++Y+LL+ SLE + N+ Sbjct: 174 HKKADIRRQDSRGNTVLHALVAIADNTRENTKFVTKVYDLLVIKCVKLYPDSSLEAIFNN 233 Query: 239 QGLTPFKLAGVEGNTVMFQHLMQ-----------KRKHVQWTCGPLTSTLYDLTEIDSWG 287 ++P +A G +FQH+++ RK W GP+ S+LYDL+ +D+ G Sbjct: 234 DSMSPLMMAAKLGKIGIFQHIIRLEIKDEEARHLSRKFRDWAYGPVYSSLYDLSMLDTCG 293 Query: 288 EELSFLELVVSSKKREAR-QILEQTPVKELVSFKWKKYGRPYFCVLASLYILYMICFTTC 346 EE+S LE++V + K E R ++L P+ EL+ KW+K+G F + Y++ MI FT Sbjct: 294 EEVSVLEILVYNSKVENRHEMLAVEPINELLRDKWQKFGAVSFYISVVSYLIAMIIFTLI 353 Query: 347 CIYRPLKLRDDNRTDPRDITILQQKLLQEAYVTHQDNIRLVGELVTVTGAVIILLLEIPD 406 YRP+ + T P Y T D +RL GE+VT+ V+ + I D Sbjct: 354 AYYRPM-----DGTPPY------------PYRTTMDYMRLAGEIVTLLTGVVFFITNIKD 396 Query: 407 IFRV---GASRYFGQTILGGPFHVIIITYASLVLLTMVMRLTNMNGEVVPLSFALVLGWC 463 +F G + F + G F ++ Y+ LV++T V+ L + + + FALVLGW Sbjct: 397 LFMKKCPGVNSLF----IDGSFQLLYFIYSVLVIITAVLYLVGIESYLAVMVFALVLGWM 452 Query: 464 SVMYFARGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAF----------HITFQ 513 + +YF RG ++ G ++IM+QK++F DL RF + + ++G+ASA + Sbjct: 453 NALYFTRGLKLTGTYSIMLQKILFKDLFRFLLVYLLFMIGYASALVSLLNPCTSQESCIE 512 Query: 514 TEDPNNLGEFSD------YPTALFSTFELFLTIIDGPANYSVDLPFMYCITYAAFAIIAT 567 T + E+ + L F+L + + D S P ++ I + I+ Sbjct: 513 TSSQCTVPEYPSCRDSSTFSKFLLDLFKLTIGMGDLEMINSAKYPAVFIILLVTYIILTF 572 Query: 568 LLMLNLFIAMMGDTHWRVAQERDELWRAQVVATTVMLERKMPRFLWP--RSG----ICGY 621 +L+LN+ IA+MG+T +V++E ++W+ Q T + +ER P + RSG + Sbjct: 573 VLLLNMLIALMGETVGQVSKESKQIWKLQWATTILDIERSFPVCMRKAFRSGEMVTVGKN 632 Query: 622 EYGLGD-RWFLRVE----NHHDQN 640 G D RW RV+ +H +QN Sbjct: 633 LDGTPDRRWCFRVDEVNWSHWNQN 656 >6DVZ-A nrPDB Length = 791 Score = 595 bits (1535), Expect = e-170, Method: Composition-based stats. Identities = 179/676 (26%), Positives = 309/676 (45%), Gaps = 82/676 (12%) Query: 49 LLQAAKENDLRLLKILLL--------NQSCDFQQ-------RGAVGETALHVAALY---D 90 + A E + L+ LL + D G+T L A L + Sbjct: 123 IFAAVSEGCVEELRELLQDLQDLCRRRRGLDVPDFLMHKLTASDTGKTCLMKALLNINPN 182 Query: 91 NLEAATLLMEAAPELAKEPA------LCEPFVGQTALHIAVMNQNLNLVRALLARGASVS 144 E +L+ A E E + GQTAL+IA+ + ++ L+A GA V+ Sbjct: 183 TKEIVRILLAFAEENDILDRFINAEYTEEAYEGQTALNIAIERRQGDITAVLIAAGADVN 242 Query: 145 ARATGAAFR-RSPHNLIYYGEHPLSFAACVGSEEIVRLLIEH-GADIRAQDSLGNTVLHI 202 A A G F + H Y+GE PL+ AAC EIV+LL+E+ DI +QDS GN +LH Sbjct: 243 AHAKGVFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMENEQTDITSQDSRGNNILHA 302 Query: 203 LI-----LQPNKTFACQMYNLLLSYDEHSDHLQSLELVPNHQGLTPFKLAGVEGNTVMFQ 257 L+ + F +MY+++L + + LE + N+ GLTP +LA G + + Sbjct: 303 LVTVAEDFKTQNDFVKRMYDMILLRSGNWE----LETMRNNDGLTPLQLAAKMGKAEILK 358 Query: 258 HLMQK-----------RKHVQWTCGPLTSTLYDLTEIDSWGEELSFLELVVSSKKREAR- 305 +++ + RK W GP++S+LYDLT +D+ + S LE++V + + R Sbjct: 359 YILSREIKEKPLRSLSRKFTDWAYGPVSSSLYDLTNVDTTTD-NSVLEIIVYNTNIDNRH 417 Query: 306 QILEQTPVKELVSFKWKKYGRPYFCVLASLYILYMICFTTCCIYRPLKLRDDNRTDPRDI 365 ++L P+ L+ KWKK+ + F + Y Y I T YRP + Sbjct: 418 EMLTLEPLHTLLHTKWKKFAKYMFFLSFCFYFFYNITLTLVSYYRPRE------------ 465 Query: 366 TILQQKLLQEAYVTHQDN-IRLVGELVTVTGAVIILLLEIPDIFRVGASRYFGQTILGGP 424 + L +TH+ + ++L+G + + A I + E IF + S Q+IL Sbjct: 466 ---DEDLPHPLALTHKMSWLQLLGRMFVLIWATCISVKEGIAIFLLRPSDL--QSILSDA 520 Query: 425 -FHVIIITYASLVLLTMVMRLTNMNGEVVPLSFALVLGWCSVMYFARGFQMLGPFTIMIQ 483 FH + A LV+L++ + L + L A+ LGW +++ + RGFQ +G +++MIQ Sbjct: 521 WFHFVFFVQAVLVILSVFLYLFAYKEYLACLVLAMALGWANMLAYTRGFQSMGMYSVMIQ 580 Query: 484 KMIFGDLMRFCWLMAVVILGFASAFHITFQ--TEDPNNLGEFSDYPTALFSTFELFLTII 541 K+I D+++F ++ + +LGF A + ++D + + + A+ F+L + + Sbjct: 581 KVILHDVLKFLFVYILFLLGFGVALASLIEKCSKDKKDCSSYGSFSDAVLELFKLTIGLG 640 Query: 542 DGPANYSVDLPFMYCITYAAFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVATT 601 D + P ++ + I+ +L+LN+ IA+MG+T V++E + +WR Q T Sbjct: 641 DLNIQQNSTYPILFLFLLITYVILTFVLLLNMLIALMGETVENVSKESERIWRLQRARTI 700 Query: 602 VMLERKMPRFLWP--RSGICGYEYGLGDRWFLRV-ENHH----------DQNPLRVLRYV 648 + E+ +P +L R G R LR+ E +++P + R Sbjct: 701 LEFEKMLPEWLRSRFRMGELCKVADEDFRLCLRINEVKWTEWKTHVSFLNEDPGPIRRTA 760 Query: 649 EAFKCSDKEDGQEQLS 664 + K D + + Sbjct: 761 DLNKIQDSSRSNSKTT 776 Score = 45.9 bits (107), Expect = 7e-05, Method: Composition-based stats. Identities = 33/170 (19%), Positives = 61/170 (35%), Gaps = 8/170 (4%) Query: 17 KLLISWPVGEQDWEQYRDRVNMLQQERIRDSPLLQAAKENDLRLLKILLLNQSCDFQQRG 76 I+ E+ +E + +N+ + R D + A D+ + + Sbjct: 201 DRFINAEYTEEAYE-GQTALNIAIERRQGDITAVLIAAGADVNAHAKGVFFNPKYQHEGF 259 Query: 77 AVGETALHVAALYDNLEAATLLMEAAPELAKEPALCEPFVGQTALH-IAVMNQNLNLVRA 135 GET L +AA + E LLME + + G LH + + ++ Sbjct: 260 YFGETPLALAACTNQPEIVQLLMEN----EQTDITSQDSRGNNILHALVTVAEDFKTQND 315 Query: 136 LLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVRLLIEH 185 + R + +G + N G PL AA +G EI++ ++ Sbjct: 316 FVKRMYDMILLRSGNWELETMRNND--GLTPLQLAAKMGKAEILKYILSR 363 >5IRX-A nrPDB Length = 636 Score = 594 bits (1530), Expect = e-170, Method: Composition-based stats. Identities = 176/644 (27%), Positives = 294/644 (45%), Gaps = 74/644 (11%) Query: 46 DSPLLQAAKENDLRLLKILLLN-QSCDFQQRGA------VGETALHVAALY---DNLEAA 95 + A +++ + L+ LL Q + + G+T L A L + Sbjct: 9 RRSIFDAVAQSNCQELESLLPFLQRSKKRLTDSEFKDPETGKTCLLKAMLNLHNGQNDTI 68 Query: 96 TLLMEAAPELAKEPALCEP------FVGQTALHIAVMNQNLNLVRALLARGASVSARATG 149 LL++ A + + GQTALHIA+ +N+ LV L+ GA V A A G Sbjct: 69 ALLLDVARKTDSLKQFVNASYTDSYYKGQTALHIAIERRNMTLVTLLVENGADVQAAANG 128 Query: 150 AAFRRSPHNL-IYYGEHPLSFAACVGSEEIVRLLIEH---GADIRAQDSLGNTVLHILIL 205 F+++ Y+GE PLS AAC IV+ L+++ ADI A+DS+GNTVLH L+ Sbjct: 129 DFFKKTKGRPGFYFGELPLSLAACTNQLAIVKFLLQNSWQPADISARDSVGNTVLHALVE 188 Query: 206 QPNKT-----FACQMYNLLLSYDEHSDHLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLM 260 + T F MYN +L LE + N +GLTP LA G + +++ Sbjct: 189 VADNTVDNTKFVTSMYNEILILGAKLHPTLKLEEITNRKGLTPLALAASSGKIGVLAYIL 248 Query: 261 QK-----------RKHVQWTCGPLTSTLYDLTEIDSWGEELSFLELVVSS--KKREARQI 307 Q+ RK +W GP+ S+LYDL+ ID+ E+ S LE++ S + + Sbjct: 249 QREIHEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTC-EKNSVLEVIAYSSSETPNRHDM 307 Query: 308 LEQTPVKELVSFKWKKYGRPYFCVLASLYILYMICFTTCCIYRPLKLRDDNRTDPRDITI 367 L P+ L+ KW ++ + F +Y LYMI FT YRP++ P Sbjct: 308 LLVEPLNRLLQDKWDRFVKRIFYFNFFVYCLYMIIFTAAAYYRPVE-----GLPPY---- 358 Query: 368 LQQKLLQEAYVTHQDNIRLVGELVTVTGAVIILLLEIPDIFRVGASRYFGQTILGGPFHV 427 + T D R+ GE+++V+G V I + S + + Sbjct: 359 -------KLKNTVGDYFRVTGEILSVSGGVYFFFRGIQYFLQRRPSL--KSLFVDSYSEI 409 Query: 428 IIITYASLVLLTMVMRLTNMNGEVVPLSFALVLGWCSVMYFARGFQMLGPFTIMIQKMIF 487 + + +L+++V+ + V + F+L +GW +++Y+ RGFQ +G + +MI+KMI Sbjct: 410 LFFVQSLFMLVSVVLYFSQRKEYVASMVFSLAMGWTNMLYYTRGFQQMGIYAVMIEKMIL 469 Query: 488 GDLMRFCWLMAVVILGFASAFHITFQTEDPNNLGEFSDYPTALFSTFELFLTIIDGPANY 547 DL RF ++ V + GF++A + G+++ + F+ + + D Sbjct: 470 RDLCRFMFVYLVFLFGFSTAVVTLIED------GKYNSLYSTCLELFKFTIGMGDLEFTE 523 Query: 548 SVDLPFMYCITYAAFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVATTVMLERK 607 + D ++ I A+ I+ +L+LN+ IA+MG+T ++AQE +W+ Q T + E+ Sbjct: 524 NYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKS 583 Query: 608 MPRFLWP--RSGI---CGYEYGLGD--RWFLRVEN----HHDQN 640 + + RSG G+ D RW RV+ + N Sbjct: 584 FLKCMRKAFRSGKLLQVGFTPDGKDDYRWCFRVDEVNWTTWNTN 627 >6MHW-A nrPDB Length = 826 Score = 580 bits (1495), Expect = e-166, Method: Composition-based stats. Identities = 171/617 (27%), Positives = 292/617 (47%), Gaps = 60/617 (9%) Query: 53 AKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALY---DNLEAATLLMEAAPELA--- 106 + + L+ G+T L A L + E +L+ A E Sbjct: 147 CRRRHDEDVPDFLM----HKLTASDTGKTCLMKALLNINPNTKEIVRILLAFAEENDILG 202 Query: 107 ---KEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFR-RSPHNLIYY 162 E + GQTAL+IA+ + ++ L+A GA V+A A GA F + H Y+ Sbjct: 203 RFINAEYTEEAYEGQTALNIAIERRQGDIAALLIAAGADVNAHAKGAFFNPKYQHEGFYF 262 Query: 163 GEHPLSFAACVGSEEIVRLLIEH-GADIRAQDSLGNTVLHILI-----LQPNKTFACQMY 216 GE PL+ AAC EIV+LL+EH DI ++DS GN +LH L+ + F +MY Sbjct: 263 GETPLALAACTNQPEIVQLLMEHEQTDITSRDSRGNNILHALVTVAEDFKTQNDFVKRMY 322 Query: 217 NLLLSYDEHSDHLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQK-----------RKH 265 +++L + + LE N+ GLTP +LA G + ++++ + RK Sbjct: 323 DMILLRSGNWE----LETTRNNDGLTPLQLAAKMGKAEILKYILSREIKEKRLRSLSRKF 378 Query: 266 VQWTCGPLTSTLYDLTEIDSWGEELSFLELVVSSKKREAR-QILEQTPVKELVSFKWKKY 324 W GP++S+LYDLT +D+ + S LE+ V + + R ++L P+ L+ KWKK+ Sbjct: 379 TDWAYGPVSSSLYDLTNVDTTTD-NSVLEITVYNTNIDNRHEMLTLEPLHTLLHMKWKKF 437 Query: 325 GRPYFCVLASLYILYMICFTTCCIYRPLKLRDDNRTDPRDITILQQKLLQEAYVTHQDN- 383 + F + Y Y I T YRP + ++ + +TH+ Sbjct: 438 AKHMFFLSFCFYFFYNITLTLVSYYRPRE---------------EEAIPHPLALTHKMGW 482 Query: 384 IRLVGELVTVTGAVIILLLEIPDIFRVGASRYFGQTILGGP-FHVIIITYASLVLLTMVM 442 ++L+G + + A+ I + E IF + S Q+IL FH + A LV+L++ + Sbjct: 483 LQLLGRMFVLIWAMCISVKEGIAIFLLRPSDL--QSILSDAWFHFVFFIQAVLVILSVFL 540 Query: 443 RLTNMNGEVVPLSFALVLGWCSVMYFARGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVIL 502 L + L A+ LGW +++Y+ RGFQ +G +++MIQK+I D+++F ++ V +L Sbjct: 541 YLFAYKEYLACLVLAMALGWANMLYYTRGFQSMGMYSVMIQKVILHDVLKFLFVYIVFLL 600 Query: 503 GFASAFHITFQT--EDPNNLGEFSDYPTALFSTFELFLTIIDGPANYSVDLPFMYCITYA 560 GF A + +D + + + A+ F+L + + D + P ++ Sbjct: 601 GFGVALASLIEKCPKDNKDCSSYGSFSDAVLELFKLTIGLGDLNIQQNSKYPILFLFLLI 660 Query: 561 AFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVATTVMLERKMPRFLWPRSGICG 620 + I+ +L+LN+ IA+MG+T V++E + +WR Q T + E+ +P +L R + Sbjct: 661 TYVILTFVLLLNMLIALMGETVENVSKESERIWRLQRARTILEFEKMLPEWLRSRFRMGE 720 Query: 621 YEYGLGD--RWFLRVEN 635 D R LR+ Sbjct: 721 LCKVAEDDFRLCLRINE 737 >6OO7-A nrPDB Length = 786 Score = 548 bits (1413), Expect = e-156, Method: Composition-based stats. Identities = 173/634 (27%), Positives = 294/634 (46%), Gaps = 74/634 (11%) Query: 55 ENDLRLLKILLLNQSCDFQQRGAVGETALHVAALY--DNLEAATLLMEAAPELAKEPA-- 110 L L+ + G+ G+T L A L D + A + + P Sbjct: 91 AGLLEYLRRTSKYLTDSEYTEGSTGKTCLMKAVLNLQDGVNACIQPLLEIDRDSGNPQPL 150 Query: 111 -----LCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEH 165 E + G +ALHIA+ ++L V+ L+ GA+V A+A G F+++ Y+GE Sbjct: 151 VNAQCTDEYYRGHSALHIAIEKRSLQCVKLLVENGANVHAKACGHFFQKNQDTCFYFGEL 210 Query: 166 PLSFAACVGSEEIVRLLIEHG---ADIRAQDSLGNTVLHILIL-----QPNKTFACQMYN 217 PLS AAC ++V L+E+ A ++AQDSLGNTVLH L++ N +MY+ Sbjct: 211 PLSLAACTKQWDVVNYLLENPHQPASLQAQDSLGNTVLHALVMIADDSAENSALVVRMYD 270 Query: 218 LLLSYDEHSDHLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQK----------RKHVQ 267 LL LE +PN +GLTP KLA EG +F+H++Q+ RK + Sbjct: 271 GLLQAGARLCPNVQLEGIPNLEGLTPLKLAAKEGKIEIFKHILQREFSAPCQSLSRKFTE 330 Query: 268 WTCGPLTSTLYDLTEIDSWGEELSFLELVVS-SKKREARQILEQTPVKELVSFKWKKYGR 326 W GP+ +LYDL +DSW EE S LE++ S+ +++ P+ +L+ KW + Sbjct: 331 WCYGPVRVSLYDLASVDSW-EENSVLEIIAFHSRSPHRHRMVVLEPLNKLLQAKWDRL-I 388 Query: 327 PYFCVLASLYILYMICFTTCCIYRPLKLRDDNRTDPRDITILQQKLLQEAYVTHQDNIRL 386 P FC Y++YM+ FT ++P L+++ T +++ L Sbjct: 389 PRFCFNFLCYLVYMLIFTAVAYHQP---------------ALEKQGFPPLKATAGNSMLL 433 Query: 387 VGELVTVTGAVIILLLEIPDIFRVGASRYFGQTILGGPFHVIIITYASLVLLTMVMRLTN 446 +G ++ + G V +LL ++ +R + + + ++ + A L +L+ V+ Sbjct: 434 LGHILILLGGVYLLLGQLWYFWRRR--LFIWISFMDSYSEILFLLQALLTVLSQVLCFLA 491 Query: 447 MNGEVVPLSFALVLGWCSVMYFARGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFAS 506 + + L +L +GW +++Y+ RGFQ G +++MI+K+I DL+RF + V + GFA Sbjct: 492 IEWYLPLLVSSLAMGWTNLLYYTRGFQHTGIYSVMIEKVILRDLLRFLLVYLVFLFGFAV 551 Query: 507 AF-HITFQTEDPNNLG----------------EFSDYPTALFSTFELF-LTIIDGPANYS 548 A ++ + ++ E Y + L ++ ELF TI G + Sbjct: 552 ALVSLSREAQNSRTPAGPNATEVGQPGAGQEDEAPPYRSILDASLELFKFTIGMGELAFQ 611 Query: 549 VDLPFMY--CITYAAFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVATTVMLER 606 L F + A+ ++ +L+LN+ IA+M +T VA + +W+ Q + + +E Sbjct: 612 EQLRFRGVVLLLLLAYVLLTYVLLLNMLIALMSETVNSVATDSWSIWKLQKAISVLEMEN 671 Query: 607 KMPRFLWP--RSG----ICGYEYGLGD-RWFLRV 633 R+G + G D RW RV Sbjct: 672 GYWWCRRKKQRAGVMLTVGTRPDGSPDERWCFRV 705 >5AN8-A nrPDB Length = 613 Score = 541 bits (1393), Expect = e-154, Method: Composition-based stats. Identities = 178/617 (28%), Positives = 295/617 (47%), Gaps = 60/617 (9%) Query: 55 ENDLRLLKILLLNQSCDFQQRGAVGETALHVAAL--YDNLEAATLLMEAAPELAKEPA-- 110 L L+ + G+ G+T L A L D + A + + P Sbjct: 16 AGLLEYLRRTSKYLTDSEYTEGSTGKTCLMKAVLNLQDGVNACIQPLLEIDRDSGNPQPL 75 Query: 111 -----LCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEH 165 E + G +ALHIA+ ++L V+ L+ GA+V A+A G F+++ Y+GE Sbjct: 76 VNAQCTDEYYRGHSALHIAIEKRSLQCVKLLVENGANVHAKACGHFFQKNQDTCFYFGEL 135 Query: 166 PLSFAACVGSEEIVRLLIEHG---ADIRAQDSLGNTVLHILIL-----QPNKTFACQMYN 217 PLS AAC ++V L+E+ A ++AQDSLGNTVLH L++ N +MY+ Sbjct: 136 PLSLAACTKQWDVVNYLLENPHPAASLQAQDSLGNTVLHALVMIADNSPENSALVVRMYD 195 Query: 218 LLLSYDEHSDHLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQK----------RKHVQ 267 LL LE +PN +GLTP KLA EG +F+H++Q+ RK + Sbjct: 196 GLLQAGARLCPNVQLEGIPNLEGLTPLKLAAKEGKIEIFKHILQREFSAPCQSLSRKFTE 255 Query: 268 WTCGPLTSTLYDLTEIDSWGEELSFLELVVS-SKKREARQILEQTPVKELVSFKWKKYGR 326 W GP+ +LYDL +DSW EE S LE++ S+ +++ P+ +L+ KW + Sbjct: 256 WCYGPVRVSLYDLASVDSW-EENSVLEIIAFHSRSPHRHRMVVLEPLNKLLQAKWDRL-I 313 Query: 327 PYFCVLASLYILYMICFTTCCIYRPLKLRDDNRTDPRDITILQQKLLQEAYVTHQDNIRL 386 P FC Y++YM+ FT ++P L+++ T +++ L Sbjct: 314 PRFCFNFLCYLVYMLIFTAVAYHQP---------------ALEKQGFPPLKATAGNSMLL 358 Query: 387 VGELVTVTGAVIILLLEIPDIFRVGASRYFGQTILGGPFHVIIITYASLVLLTMVMRLTN 446 +G ++ + G V +LL ++ +R + + + F ++ + A L +L+ V+ Sbjct: 359 LGHILILLGGVYLLLGQLWYFWRRR--LFIWISFMDSYFEILFLLQALLTVLSQVLCFLA 416 Query: 447 MNGEVVPLSFALVLGWCSVMYFARGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFAS 506 + + L +LVLGW +++Y+ RGFQ G +++MIQK+I DL+RF + V + GFA Sbjct: 417 IEWYLPLLVSSLVLGWLNLLYYTRGFQHTGIYSVMIQKVILRDLLRFLLVYLVFLFGFAV 476 Query: 507 AFHITFQTEDPNNLGEFSDYPTALFSTFELF-LTIIDGPANYSVDLPFMY--CITYAAFA 563 A ++ E + E Y + L ++ ELF TI G + L F + A+ Sbjct: 477 AL-VSLSREAQED--EAPPYRSILDASLELFKFTIGMGELAFQEQLRFRGVVLLLLLAYV 533 Query: 564 IIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVATTVMLERKMPRFLWP--RSG---- 617 ++ +L+LN+ IA+M +T VA + +W+ Q + + +E R+G Sbjct: 534 LLTYVLLLNMLIALMSETVNSVATDSWSIWKLQKAISVLEMENGYWWCRRKKQRAGVMLT 593 Query: 618 ICGYEYGLGD-RWFLRV 633 + G D RW RV Sbjct: 594 VGTRPDGSPDERWCFRV 610 >5HI9-A nrPDB Length = 770 Score = 531 bits (1368), Expect = e-151, Method: Composition-based stats. Identities = 176/622 (28%), Positives = 285/622 (45%), Gaps = 78/622 (12%) Query: 71 DFQQRGAVGETALHVAALY--DNLEAATLLMEAAPELAKEPA-------LCEPFVGQTAL 121 G+ G+T L A L D + A + + + + P E + G +AL Sbjct: 109 SAYTEGSTGKTCLMKAVLNLQDGVNACIMPLLQIDKDSGNPKPLVNAQCTDEFYQGHSAL 168 Query: 122 HIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVRL 181 HIA+ ++L V+ L+ GA V RA G F++ Y+GE PLS AAC ++V Sbjct: 169 HIAIEKRSLQCVKLLVENGADVHLRACGRFFQKHQGTCFYFGELPLSLAACTKQWDVVTY 228 Query: 182 LIEHG---ADIRAQDSLGNTVLHILIL-----QPNKTFACQMYNLLLSYDEHSDHLQSLE 233 L+E+ A + A DSLGNTVLH L++ N MY+ LL LE Sbjct: 229 LLENPHQPASLEATDSLGNTVLHALVMIADNSPENSALVIHMYDGLLQMGARLCPTVQLE 288 Query: 234 LVPNHQGLTPFKLAGVEGNTVMFQHLMQK----------RKHVQWTCGPLTSTLYDLTEI 283 + NHQGLTP KLA EG +F+H++Q+ RK +W GP+ +LYDL+ + Sbjct: 289 EISNHQGLTPLKLAAKEGKIEIFRHILQREFSGPYQPLSRKFTEWCYGPVRVSLYDLSSV 348 Query: 284 DSWGEELSFLELVV---SSKKREARQILEQTPVKELVSFKWKKYGRPYFCVLASLYILYM 340 DSW E+ S LE++ S R +L P+ +L+ KW + F + Y++YM Sbjct: 349 DSW-EKNSVLEIIAFHCKSPNRHRMVVL--EPLNKLLQEKWDRLVSR-FFFNFACYLVYM 404 Query: 341 ICFTTCCIYRPLKLRDDNRTDPRDITILQQKLLQEAYVTHQDNIRLVGELVTVTGAVIIL 400 FT ++P L Q + + T +++ L+G ++ + G + +L Sbjct: 405 FIFTVVAYHQP---------------SLDQPAIPSSKATFGESMLLLGHILILLGGIYLL 449 Query: 401 LLEIPDIFRVGASRYFGQTILGGPFHVIIITYASLVLLTMVMRLTNMNGEVVPLSFALVL 460 L ++ +R + + + F ++ + A L +L+ V+R + L +LVL Sbjct: 450 LGQLWYFWRRR--LFIWISFMDSYFEILFLLQALLTVLSQVLRFMETEWYLPLLVLSLVL 507 Query: 461 GWCSVMYFARGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAF-HITFQTEDPNN 519 GW +++Y+ RGFQ G +++MIQK+I DL+RF + V + GFA A ++ + P Sbjct: 508 GWLNLLYYTRGFQHTGIYSVMIQKVILRDLLRFLLVYLVFLFGFAVALVSLSREARSPKA 567 Query: 520 LGEFS----------------DYPTALFSTFELF-LTIIDGPANYSVDLPFMY--CITYA 560 + + Y + L ++ ELF TI G + L F + Sbjct: 568 PEDNNSTVTEQPTVGQEEEPAPYRSILDASLELFKFTIGMGELAFQEQLRFRGVVLLLLL 627 Query: 561 AFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVATTVMLERKMPRFLWP--RSG- 617 A+ ++ +L+LN+ IA+M +T VA +W+ Q + + +E R G Sbjct: 628 AYVLLTYVLLLNMLIALMSETVNHVADNSWSIWKLQKAISVLEMENGYWWCRRKKHREGR 687 Query: 618 ---ICGYEYGLGD-RWFLRVEN 635 + G D RW RVE Sbjct: 688 LLKVGTRGDGTPDERWCFRVEE 709 >6BO5-A nrPDB Length = 695 Score = 526 bits (1354), Expect = e-149, Method: Composition-based stats. Identities = 176/622 (28%), Positives = 285/622 (45%), Gaps = 78/622 (12%) Query: 71 DFQQRGAVGETALHVAAL--YDNLEAATLLMEAAPELAKEPA-------LCEPFVGQTAL 121 G+ G+T L A L D + A + + + + P E + G +AL Sbjct: 69 SAYTEGSTGKTCLMKAVLNLQDGVNACIMPLLQIDKDSGNPKPLVNAQCTDEFYQGHSAL 128 Query: 122 HIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVRL 181 HIA+ ++L V+ L+ GA V RA G F++ Y+GE PLS AAC ++V Sbjct: 129 HIAIEKRSLQCVKLLVENGADVHLRACGRFFQKHQGTCFYFGELPLSLAACTKQWDVVTY 188 Query: 182 LIEHG---ADIRAQDSLGNTVLHILIL-----QPNKTFACQMYNLLLSYDEHSDHLQSLE 233 L+E+ A + A DSLGNTVLH L++ N MY+ LL LE Sbjct: 189 LLENPHQPASLEATDSLGNTVLHALVMIADNSPENSALVIHMYDGLLQMGARLCPTVQLE 248 Query: 234 LVPNHQGLTPFKLAGVEGNTVMFQHLMQK----------RKHVQWTCGPLTSTLYDLTEI 283 + NHQGLTP KLA EG +F+H++Q+ RK +W GP+ +LYDL+ + Sbjct: 249 EISNHQGLTPLKLAAKEGKIEIFRHILQREFSGPYQPLSRKFTEWCYGPVRVSLYDLSSV 308 Query: 284 DSWGEELSFLELVV---SSKKREARQILEQTPVKELVSFKWKKYGRPYFCVLASLYILYM 340 DSW E+ S LE++ S R +L P+ +L+ KW + F + Y++YM Sbjct: 309 DSW-EKNSVLEIIAFHCKSPNRHRMVVL--EPLNKLLQEKWDRLVSR-FFFNFACYLVYM 364 Query: 341 ICFTTCCIYRPLKLRDDNRTDPRDITILQQKLLQEAYVTHQDNIRLVGELVTVTGAVIIL 400 FT ++P L Q + + T +++ L+G ++ + G + +L Sbjct: 365 FIFTVVAYHQP---------------SLDQPAIPSSKATFGESMLLLGHILILLGGIYLL 409 Query: 401 LLEIPDIFRVGASRYFGQTILGGPFHVIIITYASLVLLTMVMRLTNMNGEVVPLSFALVL 460 L ++ +R + + + F ++ + A L +L+ V+R + L +LVL Sbjct: 410 LGQLWYFWRRR--LFIWISFMDSYFEILFLLQALLTVLSQVLRFMETEWYLPLLVLSLVL 467 Query: 461 GWCSVMYFARGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAF-HITFQTEDPNN 519 GW +++Y+ RGFQ G +++MIQK+I DL+RF + V + GFA A ++ + P Sbjct: 468 GWLNLLYYTRGFQHTGIYSVMIQKVILRDLLRFLLVYLVFLFGFAVALVSLSREARSPKA 527 Query: 520 LGEFS----------------DYPTALFSTFELF-LTIIDGPANYSVDLPFMY--CITYA 560 + + Y + L ++ ELF TI G + L F + Sbjct: 528 PEDNNSTVTEQPTVGQEEEPAPYRSILDASLELFKFTIGMGELAFQEQLRFRGVVLLLLL 587 Query: 561 AFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVATTVMLERKMPRFLWP--RSG- 617 A+ ++ +L+LN+ IA+M +T VA +W+ Q + + +E R G Sbjct: 588 AYVLLTYVLLLNMLIALMSETVNHVADNSWSIWKLQKAISVLEMENGYWWCRRKKHREGR 647 Query: 618 ---ICGYEYGLGD-RWFLRVEN 635 + G D RW RVE Sbjct: 648 LLKVGTRGDGTPDERWCFRVEE 669 >2RFA-A nrPDB Length = 232 Score = 288 bits (736), Expect = 7e-78, Method: Composition-based stats. Identities = 181/221 (81%), Positives = 195/221 (88%), Gaps = 1/221 (0%) Query: 44 IRDSPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAP 103 I +SPLL AAKEND++ L LL + C+ QRGA+GETALH+AALYDNLEAA +LMEAAP Sbjct: 2 IWESPLLLAAKENDVQALSKLLKFEGCEVHQRGAMGETALHIAALYDNLEAAMVLMEAAP 61 Query: 104 ELAKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYG 163 EL EP E + GQTALHIAV+NQN+NLVRALLARGASVSARATG+ F PHNLIYYG Sbjct: 62 ELVFEPMTSELYEGQTALHIAVINQNVNLVRALLARGASVSARATGSVFHYRPHNLIYYG 121 Query: 164 EHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYD 223 EHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYD Sbjct: 122 EHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYD 181 Query: 224 EHSDHLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQKRK 264 DHL+SLELVPN+QGLTPFKLAGVEGN VMFQHLMQKRK Sbjct: 182 G-GDHLKSLELVPNNQGLTPFKLAGVEGNIVMFQHLMQKRK 221 >2ETB-A nrPDB Length = 256 Score = 223 bits (568), Expect = 3e-58, Method: Composition-based stats. Identities = 72/210 (34%), Positives = 103/210 (49%), Gaps = 17/210 (8%) Query: 71 DFQQRGAVGETALHVAAL--YDNLEAATLLMEAAPELAKEPA-------LCEPFVGQTAL 121 G+ G+T L A L D + A + + + + P E + G +AL Sbjct: 35 SAYTEGSTGKTCLMKAVLNLQDGVNACIMPLLQIDKDSGNPKPLVNAQCTDEFYQGHSAL 94 Query: 122 HIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVRL 181 HIA+ ++L V+ L+ GA V RA G F++ Y+GE PLS AAC ++V Sbjct: 95 HIAIEKRSLQCVKLLVENGADVHLRACGRFFQKHQGTCFYFGELPLSLAACTKQWDVVTY 154 Query: 182 LIEH---GADIRAQDSLGNTVLHILIL-----QPNKTFACQMYNLLLSYDEHSDHLQSLE 233 L+E+ A + A DSLGNTVLH L++ N MY+ LL LE Sbjct: 155 LLENPHQPASLEATDSLGNTVLHALVMIADNSPENSALVIHMYDGLLQMGARLCPTVQLE 214 Query: 234 LVPNHQGLTPFKLAGVEGNTVMFQHLMQKR 263 + NHQGLTP KLA EG +F+H++Q+ Sbjct: 215 EISNHQGLTPLKLAAKEGKIEIFRHILQRE 244 >2F37-A nrPDB Length = 251 Score = 221 bits (564), Expect = 7e-58, Method: Composition-based stats. Identities = 70/226 (30%), Positives = 105/226 (46%), Gaps = 17/226 (7%) Query: 55 ENDLRLLKILLLNQSCDFQQRGAVGETALHVAALY--DNLEAATLLMEAAPELAKEPA-- 110 L + G+ G+T L A L D + A L + + P Sbjct: 24 AGLPEYLSKTSKYLTDSEYTEGSTGKTCLMKAVLNLKDGVNACILPLLQIDRDSGNPQPL 83 Query: 111 -----LCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEH 165 + + G +ALHIA+ ++L V+ L+ GA+V ARA G F++ Y+GE Sbjct: 84 VNAQCTDDYYRGHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGEL 143 Query: 166 PLSFAACVGSEEIVRLLIEH---GADIRAQDSLGNTVLHILILQPNKT-----FACQMYN 217 PLS AAC ++V L+E+ A ++A DS GNTVLH L++ + + MY+ Sbjct: 144 PLSLAACTKQWDVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYD 203 Query: 218 LLLSYDEHSDHLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQKR 263 LL LE + N Q LTP KLA EG +F+H++Q+ Sbjct: 204 GLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRHILQRE 249 >3W9G-A nrPDB Length = 260 Score = 197 bits (501), Expect = 1e-50, Method: Composition-based stats. Identities = 70/205 (34%), Positives = 102/205 (49%), Gaps = 18/205 (8%) Query: 77 AVGETALHVAALY---DNLEAATLLME------AAPELAKEPALCEPFVGQTALHIAVMN 127 + G+T L A L + +L++ E P + GQTALHIA+ Sbjct: 44 STGKTCLPKALLNLSAGRNDTIPILLDIAEKTGNMREFINSPFRDVYYRGQTALHIAIER 103 Query: 128 QNLNLVRALLARGASVSARATGAAFR-RSPHNLIYYGEHPLSFAACVGSEEIVRLLIEHG 186 + + V L+ +GA V A+A G F+ + Y+GE PLS AAC IV L E+G Sbjct: 104 RCKHYVELLVEKGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTNQPHIVHYLTENG 163 Query: 187 ---ADIRAQDSLGNTVLHILI-----LQPNKTFACQMYNLLLSYDEHSDHLQSLELVPNH 238 AD+R QDS GNTVLH L+ + N F +MY+LLL +LE + N+ Sbjct: 164 HKQADLRRQDSRGNTVLHALVAIADNTRENTKFVTKMYDLLLIKCAKLFPDTNLEALLNN 223 Query: 239 QGLTPFKLAGVEGNTVMFQHLMQKR 263 GL+P +A G +FQH++++ Sbjct: 224 DGLSPLMMAAKTGKIGIFQHIIRRE 248 >4DX2-A nrPDB Length = 259 Score = 196 bits (499), Expect = 2e-50, Method: Composition-based stats. Identities = 71/205 (34%), Positives = 102/205 (49%), Gaps = 18/205 (8%) Query: 77 AVGETALHVAALY---DNLEAATLLME------AAPELAKEPALCEPFVGQTALHIAVMN 127 + G+T L A L + +L++ E P + GQTALHIA+ Sbjct: 42 STGKTCLPKALLNLSNGRNDTIPVLLDIAERTGNMREFINSPFRDIYYRGQTALHIAIER 101 Query: 128 QNLNLVRALLARGASVSARATGAAFR-RSPHNLIYYGEHPLSFAACVGSEEIVRLLIEHG 186 + + V L+A+GA V A+A G F+ + Y+GE PLS AAC IV L E+ Sbjct: 102 RCKHYVELLVAQGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTNQPHIVNYLTENP 161 Query: 187 ---ADIRAQDSLGNTVLHILI-----LQPNKTFACQMYNLLLSYDEHSDHLQSLELVPNH 238 AD+R QDS GNTVLH L+ + N F +MY+LLL +LE V N+ Sbjct: 162 HKKADMRRQDSRGNTVLHALVAIADNTRENTKFVTKMYDLLLLKCARLFPDSNLEAVLNN 221 Query: 239 QGLTPFKLAGVEGNTVMFQHLMQKR 263 GL+P +A G +FQH++++ Sbjct: 222 DGLSPLMMAAKTGKIGIFQHIIRRE 246 >5H76-A nrPDB Length = 201 Score = 195 bits (496), Expect = 5e-50, Method: Composition-based stats. Identities = 59/201 (29%), Positives = 89/201 (44%), Gaps = 26/201 (12%) Query: 47 SPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELA 106 LL+AA+ ++IL+ N D G T LH+AA +LE +L++ ++ Sbjct: 8 RKLLEAARAGQDDEVRILMAN-GADVNAADNTGTTPLHLAAYSGHLEIVEVLLKHGADVD 66 Query: 107 KEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHP 166 G T LH+A +L +V LL GA V+A + G P Sbjct: 67 -----ASDVFGYTPLHLAAYWGHLEIVEVLLKNGADVNAMDSD-------------GMTP 108 Query: 167 LSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFA--CQMYNLL----L 220 L AA G EIV +L++HGA + AQD G T I I N+ A Y +L L Sbjct: 109 LHLAAKWGYLEIVEVLLKHGA-VNAQDKFGKTAFDISIDNGNEDLAQILAFYEILHLPNL 167 Query: 221 SYDEHSDHLQSLELVPNHQGL 241 + ++ + +QSL+ P+ Sbjct: 168 NEEQRNAFIQSLKDDPSQSAN 188 Score = 127 bits (318), Expect = 2e-29, Method: Composition-based stats. Identities = 43/173 (24%), Positives = 67/173 (38%), Gaps = 26/173 (15%) Query: 121 LHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVR 180 L A + VR L+A GA V+A G PL AA G EIV Sbjct: 10 LLEAARAGQDDEVRILMANGADVNAADNT-------------GTTPLHLAAYSGHLEIVE 56 Query: 181 LLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHSDHLQSLELVPNHQG 240 +L++HGAD+ A D G T LH+ + ++ +LL + + S G Sbjct: 57 VLLKHGADVDASDVFGYTPLHLAAYWGH----LEIVEVLLKNGADVNAMDS-------DG 105 Query: 241 LTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLTSTLYDLTEIDSWGEELSFL 293 +TP LA G + + L++ T +D++ + + L Sbjct: 106 MTPLHLAAKWGYLEIVEVLLKHGAVN--AQDKFGKTAFDISIDNGNEDLAQIL 156 Score = 54.0 bits (128), Expect = 3e-07, Method: Composition-based stats. Identities = 31/159 (19%), Positives = 49/159 (30%), Gaps = 57/159 (35%) Query: 167 LSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHS 226 L AA G ++ VR+L+ +GAD+ A D Sbjct: 10 LLEAARAGQDDEVRILMANGADVNAAD--------------------------------- 36 Query: 227 DHLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHVQWT----CGPLTSTLYDLTE 282 + G TP LA G+ + + L++ V + PL Y Sbjct: 37 -----------NTGTTPLHLAAYSGHLEIVEVLLKHGADVDASDVFGYTPLHLAAY---- 81 Query: 283 IDSWGEELSFLELVVSSKKREARQILEQTPVKELVSFKW 321 WG L+ + A TP+ ++ KW Sbjct: 82 ---WGHLEIVEVLLKNGADVNAMDSDGMTPLH--LAAKW 115 >6MWQ-A nrPDB Length = 493 Score = 195 bits (495), Expect = 6e-50, Method: Composition-based stats. Identities = 57/179 (31%), Positives = 80/179 (44%), Gaps = 19/179 (10%) Query: 47 SPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELA 106 LL+AA+ ++IL+ N D G T LH+AA +LE +L++ ++ Sbjct: 7 KKLLEAARAGQDDEVRILMAN-GADVNALDRFGLTPLHLAAQRGHLEIVEVLLKCGADVN 65 Query: 107 KEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHP 166 GQT LH+A +L +V LL GA V+A G+ P Sbjct: 66 -----AADLWGQTPLHLAATAGHLEIVEVLLKYGADVNALD-------------LIGKTP 107 Query: 167 LSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEH 225 L A G EIV +L++HGAD+ AQD G T I I N+ A + L LS H Sbjct: 108 LHLTAIDGHLEIVEVLLKHGADVNAQDKFGKTAFDISIDNGNEDLAEILQKLNLSDIAH 166 Score = 134 bits (337), Expect = 1e-31, Method: Composition-based stats. Identities = 44/184 (23%), Positives = 73/184 (39%), Gaps = 25/184 (13%) Query: 121 LHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVR 180 L A + VR L+A GA V+A +G PL AA G EIV Sbjct: 9 LLEAARAGQDDEVRILMANGADVNALDR-------------FGLTPLHLAAQRGHLEIVE 55 Query: 181 LLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHSDHLQSLELVPNHQG 240 +L++ GAD+ A D G T LH+ + ++ +LL Y + L + G Sbjct: 56 VLLKCGADVNAADLWGQTPLHLAATAGH----LEIVEVLLKYGADVNALDLI-------G 104 Query: 241 LTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLTSTLYDLTEIDSWGEELSFLELVVSSK 300 TP L ++G+ + + L++ V T +D++ + + L+ + S Sbjct: 105 KTPLHLTAIDGHLEIVEVLLKHGADVN-AQDKFGKTAFDISIDNGNEDLAEILQKLNLSD 163 Query: 301 KREA 304 Sbjct: 164 IAHR 167 Score = 84.8 bits (208), Expect = 1e-16, Method: Composition-based stats. Identities = 24/93 (25%), Positives = 44/93 (47%), Gaps = 6/93 (6%) Query: 46 DSPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPEL 105 +PL AA L ++++LL D +G+T LH+ A+ +LE +L++ ++ Sbjct: 72 QTPLHLAATAGHLEIVEVLLKY-GADVNALDLIGKTPLHLTAIDGHLEIVEVLLKHGADV 130 Query: 106 AKEPALCEPFVGQTALHIAVMNQNLNLVRALLA 138 + G+TA I++ N N +L L Sbjct: 131 NAQDKF-----GKTAFDISIDNGNEDLAEILQK 158 Score = 55.1 bits (131), Expect = 1e-07, Method: Composition-based stats. Identities = 28/148 (18%), Positives = 45/148 (30%), Gaps = 47/148 (31%) Query: 167 LSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHS 226 L AA G ++ VR+L+ +GAD+ A D Sbjct: 9 LLEAARAGQDDEVRILMANGADVNALDRF------------------------------- 37 Query: 227 DHLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLTSTLYDLTEIDSW 286 GLTP LA G+ + + L++ V T L Sbjct: 38 -------------GLTPLHLAAQRGHLEIVEVLLKCGADVNAA-DLWGQTPLHLAATAGH 83 Query: 287 GEELSFLELVVSSKKREARQILEQTPVK 314 E + L + A ++ +TP+ Sbjct: 84 LEIVEVL--LKYGADVNALDLIGKTPLH 109 >5AQ9-A nrPDB Length = 422 Score = 193 bits (490), Expect = 2e-49, Method: Composition-based stats. Identities = 50/170 (29%), Positives = 73/170 (42%), Gaps = 19/170 (11%) Query: 47 SPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELA 106 LL+AA+ ++IL+ N D G T LH+AA +LE +L++ ++ Sbjct: 16 RKLLEAARAGQDDEVRILMAN-GADVNAADNTGTTPLHLAAYSGHLEIVEVLLKHGADVD 74 Query: 107 KEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHP 166 G T LH+A +L +V LL GA V+A + G P Sbjct: 75 -----ASDVFGYTPLHLAAYWGHLEIVEVLLKNGADVNAMDSD-------------GMTP 116 Query: 167 LSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMY 216 L AA G EIV +L++HGAD+ AQD G T + N + Sbjct: 117 LHLAAKWGYLEIVEVLLKHGADVNAQDKFGKTPFDLADDNGNDDVGTLLQ 166 Score = 152 bits (384), Expect = 5e-37, Method: Composition-based stats. Identities = 47/186 (25%), Positives = 76/186 (40%), Gaps = 25/186 (13%) Query: 121 LHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVR 180 L A + VR L+A GA V+A G PL AA G EIV Sbjct: 18 LLEAARAGQDDEVRILMANGADVNAADNT-------------GTTPLHLAAYSGHLEIVE 64 Query: 181 LLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHSDHLQSLELVPNHQG 240 +L++HGAD+ A D G T LH+ + ++ +LL + + S G Sbjct: 65 VLLKHGADVDASDVFGYTPLHLAAYWGH----LEIVEVLLKNGADVNAMDS-------DG 113 Query: 241 LTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLTSTLYDLTEIDSWGEELSFLELVVSSK 300 +TP LA G + + L++ V T +DL + + + + L++ ++ Sbjct: 114 MTPLHLAAKWGYLEIVEVLLKHGADVN-AQDKFGKTPFDLADDNGNDDVGTLLQVAAAAD 172 Query: 301 KREARQ 306 + AR Sbjct: 173 QLGARV 178 Score = 45.5 bits (106), Expect = 8e-05, Method: Composition-based stats. Identities = 18/57 (31%), Positives = 27/57 (47%), Gaps = 1/57 (1%) Query: 47 SPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAP 103 +PL AAK L ++++LL D + G+T +A N + TLL AA Sbjct: 115 TPLHLAAKWGYLEIVEVLLK-HGADVNAQDKFGKTPFDLADDNGNDDVGTLLQVAAA 170 >4N5Q-A nrPDB Length = 257 Score = 193 bits (489), Expect = 4e-49, Method: Composition-based stats. Identities = 71/249 (28%), Positives = 112/249 (44%), Gaps = 35/249 (14%) Query: 46 DSPLLQAAKENDLRLLKILLL--------NQSCDFQQ-------RGAVGETALHVAALY- 89 + A E + L+ LL + D G+T L A L Sbjct: 4 KKRIFAAVSEGCVEELRELLQDLQDLCRRRRGLDVPDFLMHKLTASDTGKTCLMKALLNI 63 Query: 90 --DNLEAATLLMEAAPELAKEPA------LCEPFVGQTALHIAVMNQNLNLVRALLARGA 141 + E +L+ A E E + GQTAL+IA+ + ++ L+A GA Sbjct: 64 NPNTKEIVRILLAFAEENDILDRFINAEYTEEAYEGQTALNIAIERRQGDITAVLIAAGA 123 Query: 142 SVSARATGAAFR-RSPHNLIYYGEHPLSFAACVGSEEIVRLLIEH-GADIRAQDSLGNTV 199 V+A A G F + H Y+GE PL+ AAC EIV+LL+E+ DI +QDS GN + Sbjct: 124 DVNAHAKGVFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMENEQTDITSQDSRGNNI 183 Query: 200 LHILI-----LQPNKTFACQMYNLLLSYDEHSDHLQSLELVPNHQGLTPFKLAGVEGNTV 254 LH L+ + F +MY+++L + + LE + N+ GLTP +LA G Sbjct: 184 LHALVTVAEDFKTQNDFVKRMYDMILLRSGNWE----LETMRNNDGLTPLQLAAKMGKAE 239 Query: 255 MFQHLMQKR 263 + ++++ + Sbjct: 240 ILKYILSRE 248 >5AQA-A nrPDB Length = 418 Score = 192 bits (487), Expect = 5e-49, Method: Composition-based stats. Identities = 54/198 (27%), Positives = 85/198 (42%), Gaps = 24/198 (12%) Query: 47 SPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELA 106 LL+AA+ ++IL+ N D G T LH+AA +LE +L++ ++ Sbjct: 16 RKLLEAARAGQDDEVRILMAN-GADVNAADNTGTTPLHLAAYSGHLEIVEVLLKHGADVD 74 Query: 107 KEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHP 166 G T LH+A +L +V LL GA V+A + G P Sbjct: 75 -----ASDVFGYTPLHLAAYWGHLEIVEVLLKNGADVNAMDSD-------------GMTP 116 Query: 167 LSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSY---- 222 L AA G +EIV +L++ GAD+ AQD G L + Q + A ++ L Sbjct: 117 LHLAAKWGYKEIVEVLLKAGADVDAQDKFGKRPLWLAADQGHAEIAAKLVAARLKARVGY 176 Query: 223 -DEHSDHLQSLELVPNHQ 239 + + + LE V + + Sbjct: 177 IELDLNSGKILESVRSEE 194 Score = 119 bits (298), Expect = 5e-27, Method: Composition-based stats. Identities = 44/173 (25%), Positives = 64/173 (36%), Gaps = 25/173 (14%) Query: 121 LHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVR 180 L A + VR L+A GA V+A G PL AA G EIV Sbjct: 18 LLEAARAGQDDEVRILMANGADVNAADNT-------------GTTPLHLAAYSGHLEIVE 64 Query: 181 LLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHSDHLQSLELVPNHQG 240 +L++HGAD+ A D G T LH+ + ++ +LL + + S G Sbjct: 65 VLLKHGADVDASDVFGYTPLHLAAYWGH----LEIVEVLLKNGADVNAMDS-------DG 113 Query: 241 LTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLTSTLYDLTEIDSWGEELSFL 293 +TP LA G + + L++ V L E + L Sbjct: 114 MTPLHLAAKWGYKEIVEVLLKAGADVD-AQDKFGKRPLWLAADQGHAEIAAKL 165 Score = 54.0 bits (128), Expect = 2e-07, Method: Composition-based stats. Identities = 31/159 (19%), Positives = 49/159 (30%), Gaps = 57/159 (35%) Query: 167 LSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHS 226 L AA G ++ VR+L+ +GAD+ A D Sbjct: 18 LLEAARAGQDDEVRILMANGADVNAAD--------------------------------- 44 Query: 227 DHLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHVQWT----CGPLTSTLYDLTE 282 + G TP LA G+ + + L++ V + PL Y Sbjct: 45 -----------NTGTTPLHLAAYSGHLEIVEVLLKHGADVDASDVFGYTPLHLAAY---- 89 Query: 283 IDSWGEELSFLELVVSSKKREARQILEQTPVKELVSFKW 321 WG L+ + A TP+ ++ KW Sbjct: 90 ---WGHLEIVEVLLKNGADVNAMDSDGMTPLH--LAAKW 123 >5MIO-C nrPDB Length = 573 Score = 189 bits (480), Expect = 4e-48, Method: Composition-based stats. Identities = 54/174 (31%), Positives = 84/174 (48%), Gaps = 19/174 (10%) Query: 47 SPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELA 106 LL+AA+ +++L+ N D A G T LH+AA Y +LE +L++ +++ Sbjct: 412 KKLLEAARAGQDDEVRVLMAN-GADVNATDASGLTPLHLAATYGHLEIVEVLLKHGADVS 470 Query: 107 KEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHP 166 +G T LH+A + +L +V LL GA V+A T +G+ P Sbjct: 471 -----ASDLMGSTPLHLAALIGHLEIVEVLLKHGADVNAVDT-------------WGDTP 512 Query: 167 LSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLL 220 L AA +G +IV L++HGAD+ AQD G T I ++ A + L L Sbjct: 513 LRLAAVMGHLKIVEALLKHGADVNAQDKFGKTAYDTSIDNGSEDLAEILQKLNL 566 Score = 142 bits (357), Expect = 6e-34, Method: Composition-based stats. Identities = 50/171 (29%), Positives = 77/171 (45%), Gaps = 26/171 (15%) Query: 121 LHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVR 180 L A + VR L+A GA V+A G PL AA G EIV Sbjct: 414 LLEAARAGQDDEVRVLMANGADVNATDAS-------------GLTPLHLAATYGHLEIVE 460 Query: 181 LLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHSDHLQSLELVPNHQG 240 +L++HGAD+ A D +G+T LH+ L + ++ +LL + + + + G Sbjct: 461 VLLKHGADVSASDLMGSTPLHLAALIGH----LEIVEVLLKHGADVNAVDTW-------G 509 Query: 241 LTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLTSTLYDLTEIDSWGEELS 291 TP +LA V G+ + + L++ V T YD T ID+ E+L+ Sbjct: 510 DTPLRLAAVMGHLKIVEALLKHGADVN-AQDKFGKTAYD-TSIDNGSEDLA 558 Score = 38.2 bits (87), Expect = 0.015, Method: Composition-based stats. Identities = 14/55 (25%), Positives = 26/55 (47%), Gaps = 1/55 (1%) Query: 46 DSPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLME 100 D+PL AA L++++ LL D + G+TA + + + A +L + Sbjct: 510 DTPLRLAAVMGHLKIVEALLK-HGADVNAQDKFGKTAYDTSIDNGSEDLAEILQK 563 >2NYJ-A nrPDB Length = 273 Score = 187 bits (475), Expect = 1e-47, Method: Composition-based stats. Identities = 75/245 (30%), Positives = 113/245 (46%), Gaps = 25/245 (10%) Query: 46 DSPLLQAAKENDLRLLKILLLN-QSCDFQQRGA------VGETALHVAALY---DNLEAA 95 + A +++ + L+ LL Q + + G+T L A L + Sbjct: 14 RRSIFDAVAQSNCQELESLLPFLQRSKKRLTDSEFKDPETGKTCLLKAMLNLHNGQNDTI 73 Query: 96 TLLMEAAPELAKEPALCEP------FVGQTALHIAVMNQNLNLVRALLARGASVSARATG 149 LL++ A + + GQTALHIA+ +N+ LV L+ GA V A A G Sbjct: 74 ALLLDVARKTDSLKQFVNASYTDSYYKGQTALHIAIERRNMTLVTLLVENGADVQAAANG 133 Query: 150 AAFRRSPHNL-IYYGEHPLSFAACVGSEEIVRLLIEH---GADIRAQDSLGNTVLHILIL 205 F+++ Y+GE PLS AAC IV+ L+++ ADI A+DS+GNTVLH L+ Sbjct: 134 DFFKKTKGRPGFYFGELPLSLAACTNQLAIVKFLLQNSWQPADISARDSVGNTVLHALVE 193 Query: 206 QPNKT-----FACQMYNLLLSYDEHSDHLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLM 260 + T F MYN +L LE + N +GLTP LA G + +++ Sbjct: 194 VADNTVDNTKFVTSMYNEILILGAKLHPTLKLEEITNRKGLTPLALAASSGKIGVLAYIL 253 Query: 261 QKRKH 265 Q+ H Sbjct: 254 QREIH 258 >5AQB-A nrPDB Length = 428 Score = 187 bits (475), Expect = 1e-47, Method: Composition-based stats. Identities = 52/169 (30%), Positives = 75/169 (44%), Gaps = 20/169 (11%) Query: 47 SPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELA 106 LL+AA+ +IL+ N D VG T LH+AA +LE L++ ++ Sbjct: 16 KKLLEAARAGQDDECRILMAN-GADVNALDEVGWTPLHLAAW-GHLEIVECLLKNGADVN 73 Query: 107 KEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHP 166 G T LH+A + +L +V LL GA V+A G P Sbjct: 74 -----AADIDGYTPLHLAAFSGHLEIVEVLLKYGADVNADDQA-------------GFTP 115 Query: 167 LSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQM 215 L AA G EIV +L+++GAD+ AQD G T + I N+ A + Sbjct: 116 LHLAAIFGHLEIVEVLLKNGADVNAQDKFGKTPRDLAIDNGNEDIAEVL 164 Score = 128 bits (321), Expect = 9e-30, Method: Composition-based stats. Identities = 45/193 (23%), Positives = 69/193 (35%), Gaps = 33/193 (17%) Query: 121 LHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVR 180 L A + R L+A GA V+A G PL AA G EIV Sbjct: 18 LLEAARAGQDDECRILMANGADVNALDE-------------VGWTPLHLAA-WGHLEIVE 63 Query: 181 LLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHSDHLQSLELVPNHQG 240 L+++GAD+ A D G T LH+ + ++ +LL Y + G Sbjct: 64 CLLKNGADVNAADIDGYTPLHLAAFSGH----LEIVEVLLKYGADVNADDQ-------AG 112 Query: 241 LTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLTSTLYDLTEIDSWGEELSFLELVVS-- 298 TP LA + G+ + + L++ V T DL + + L + Sbjct: 113 FTPLHLAAIFGHLEIVEVLLKNGADVN-AQDKFGKTPRDLAIDNGNEDIAEVLGKAATLV 171 Query: 299 -----SKKREARQ 306 + + AR Sbjct: 172 KVKDAADQLGARV 184 Score = 87.5 bits (215), Expect = 2e-17, Method: Composition-based stats. Identities = 24/104 (23%), Positives = 45/104 (43%), Gaps = 6/104 (5%) Query: 47 SPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELA 106 +PL AA L ++++LL D G T LH+AA++ +LE +L++ ++ Sbjct: 81 TPLHLAAFSGHLEIVEVLLKY-GADVNADDQAGFTPLHLAAIFGHLEIVEVLLKNGADVN 139 Query: 107 KEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGA 150 + G+T +A+ N N ++ L V + Sbjct: 140 AQDKF-----GKTPRDLAIDNGNEDIAEVLGKAATLVKVKDAAD 178 >5AQ7-A nrPDB Length = 418 Score = 186 bits (473), Expect = 2e-47, Method: Composition-based stats. Identities = 54/198 (27%), Positives = 83/198 (41%), Gaps = 24/198 (12%) Query: 47 SPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELA 106 LL+AA+ ++ILL N D G T LH+AA +L +L++ ++ Sbjct: 16 KKLLEAARAGQDDEVRILLAN-GADVNTADETGFTPLHLAAWEGHLGIVEVLLKNGADVN 74 Query: 107 KEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHP 166 G T LH+A +L +V LL GA V+A G P Sbjct: 75 -----ANDERGHTPLHLAAYTGHLEIVEVLLKNGAGVNATDV-------------IGTAP 116 Query: 167 LSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSY---- 222 L AA G +EIV +L++ GAD+ AQD G L + Q + A ++ L Sbjct: 117 LHLAAMWGYKEIVEVLLKAGADVDAQDKFGKRPLWLAADQGHAEIAAKLVAARLKARVGY 176 Query: 223 -DEHSDHLQSLELVPNHQ 239 + + + LE V + + Sbjct: 177 IELDLNSGKILESVRSEE 194 Score = 109 bits (273), Expect = 4e-24, Method: Composition-based stats. Identities = 40/173 (23%), Positives = 61/173 (35%), Gaps = 25/173 (14%) Query: 121 LHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVR 180 L A + VR LLA GA V+ G PL AA G IV Sbjct: 18 LLEAARAGQDDEVRILLANGADVNTADET-------------GFTPLHLAAWEGHLGIVE 64 Query: 181 LLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHSDHLQSLELVPNHQG 240 +L+++GAD+ A D G+T LH+ + ++ +LL + + G Sbjct: 65 VLLKNGADVNANDERGHTPLHLAAYTGH----LEIVEVLLKNGAGVNATDVI-------G 113 Query: 241 LTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLTSTLYDLTEIDSWGEELSFL 293 P LA + G + + L++ V L E + L Sbjct: 114 TAPLHLAAMWGYKEIVEVLLKAGADVD-AQDKFGKRPLWLAADQGHAEIAAKL 165 Score = 47.8 bits (112), Expect = 2e-05, Method: Composition-based stats. Identities = 27/155 (17%), Positives = 46/155 (29%), Gaps = 49/155 (31%) Query: 167 LSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHS 226 L AA G ++ VR+L+ +GAD+ D Sbjct: 18 LLEAARAGQDDEVRILLANGADVNTAD--------------------------------- 44 Query: 227 DHLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLTSTLYDLTEIDSW 286 G TP LA EG+ + + L++ V T L Sbjct: 45 -----------ETGFTPLHLAAWEGHLGIVEVLLKNGADVN-ANDERGHTPLHLAAYTGH 92 Query: 287 GEELSFLELVVSSKKREARQILEQTPVKELVSFKW 321 E + L + + A ++ P+ ++ W Sbjct: 93 LEIVEVL--LKNGAGVNATDVIGTAPLH--LAAMW 123 >4OAU-C nrPDB Length = 699 Score = 184 bits (467), Expect = 1e-46, Method: Composition-based stats. Identities = 56/233 (24%), Positives = 104/233 (44%), Gaps = 19/233 (8%) Query: 36 VNMLQQERIRDSPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAA 95 VN ++E +PL A + + ++ LLL D R G T +AA+ +++ Sbjct: 31 VNFQEEEGGW-TPLHNAVQMSREDIV-ELLLRHGADPVLRKKNGATPFILAAIAGSVKLL 88 Query: 96 TLLMEAAPELAKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRS 155 L + ++ + F G TA A + + ++ L RGA+V+ R + Sbjct: 89 KLFLSKGADVNEC-----DFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKT---KED 140 Query: 156 PHNLIYYGEHPLSFAACVGSEEIVRLLI-EHGADIRAQDSLGNTVLHILILQPNKTFACQ 214 L G L AA G E++++L+ E GAD+ A D++G L +L + + Sbjct: 141 QERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEA 200 Query: 215 MYNLLLSYDEHSDHLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHVQ 267 + +LLL + + V +G TP LA + + + Q L++ ++H++ Sbjct: 201 ITHLLLDHGADVN-------VRGERGKTPLILAVEKKHLGLVQRLLE-QEHIE 245 Score = 69.4 bits (168), Expect = 5e-12, Method: Composition-based stats. Identities = 33/139 (23%), Positives = 53/139 (38%), Gaps = 24/139 (17%) Query: 50 LQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELAKEP 109 L ++ ++D+ + LLL+ D RG G+T L +A +L L+E Sbjct: 190 LLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQ----EHIE 245 Query: 110 ALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSF 169 G+TAL +AV + + L RGAS L Sbjct: 246 INDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGD-------------------LVM 286 Query: 170 AACVGSEE-IVRLLIEHGA 187 A + +V++L+ HGA Sbjct: 287 TARRNYDHSLVKVLLSHGA 305 Score = 57.4 bits (137), Expect = 2e-08, Method: Composition-based stats. Identities = 29/150 (19%), Positives = 56/150 (37%), Gaps = 13/150 (8%) Query: 167 LSFAACVGSEEIVRLLIEHGADIRAQDSLGN-TVLHILILQPNKTFACQMYNLLLSYDEH 225 L A ++V+ L+E GA++ Q+ G T LH + + LLL + Sbjct: 9 LIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIV----ELLLRHGAD 64 Query: 226 SDHLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLTSTLYDLTEIDS 285 ++ G TPF LA + G+ + + + K V T + + Sbjct: 65 -------PVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNEC-DFYGFTAFMEAAVYG 116 Query: 286 WGEELSFLELVVSSKKREARQILEQTPVKE 315 + L FL ++ + +Q +++ Sbjct: 117 KVKALKFLYKRGANVNLRRKTKEDQERLRK 146 Score = 46.6 bits (109), Expect = 4e-05, Method: Composition-based stats. Identities = 23/96 (23%), Positives = 41/96 (42%), Gaps = 10/96 (10%) Query: 46 DSPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPEL 105 +PL+ A ++ L L++ LL + + + G+TAL +A + A LL + Sbjct: 220 KTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGAST 279 Query: 106 AKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGA 141 + A N + +LV+ LL+ GA Sbjct: 280 DCGDL----------VMTARRNYDHSLVKVLLSHGA 305 >6FES-A nrPDB Length = 367 Score = 179 bits (455), Expect = 3e-45, Method: Composition-based stats. Identities = 51/166 (30%), Positives = 73/166 (43%), Gaps = 19/166 (11%) Query: 47 SPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELA 106 LL+AA+ ++ILL N D G T LH+AA +L +L++ ++ Sbjct: 8 KKLLEAARAGQDDEVRILLAN-GADVNTADETGFTPLHLAAWEGHLGIVEVLLKNGADVN 66 Query: 107 KEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHP 166 G T LH+A +L +V LL GA V+A G P Sbjct: 67 -----ANDERGHTPLHLAAYTGHLEIVEVLLKNGAGVNATDV-------------IGTAP 108 Query: 167 LSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFA 212 L AA G EEIV +L+++GAD RAQD G T + ++ A Sbjct: 109 LHLAAMWGHEEIVEVLLKNGADARAQDKFGKTPEDLARDNGYESVA 154 Score = 114 bits (285), Expect = 1e-25, Method: Composition-based stats. Identities = 39/165 (23%), Positives = 62/165 (37%), Gaps = 25/165 (15%) Query: 121 LHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVR 180 L A + VR LLA GA V+ G PL AA G IV Sbjct: 10 LLEAARAGQDDEVRILLANGADVNTADET-------------GFTPLHLAAWEGHLGIVE 56 Query: 181 LLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHSDHLQSLELVPNHQG 240 +L+++GAD+ A D G+T LH+ + ++ +LL + + G Sbjct: 57 VLLKNGADVNANDERGHTPLHLAAYTGH----LEIVEVLLKNGAGVNATDVI-------G 105 Query: 241 LTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLTSTLYDLTEIDS 285 P LA + G+ + + L++ + T DL + Sbjct: 106 TAPLHLAAMWGHEEIVEVLLKNGADAR-AQDKFGKTPEDLARDNG 149 Score = 37.4 bits (85), Expect = 0.021, Method: Composition-based stats. Identities = 13/51 (25%), Positives = 22/51 (43%), Gaps = 1/51 (1%) Query: 47 SPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATL 97 +PL AA ++++LL N D + + G+T +A A L Sbjct: 107 APLHLAAMWGHEEIVEVLLKN-GADARAQDKFGKTPEDLARDNGYESVARL 156 >6G1K-A nrPDB Length = 921 Score = 175 bits (444), Expect = 6e-44, Method: Composition-based stats. Identities = 102/663 (15%), Positives = 221/663 (33%), Gaps = 116/663 (17%) Query: 23 PVGEQDWEQYRDRVNML-----QQERIRDSPLLQAAKENDLRLLKILLL----NQSCDFQ 73 D YRDR+ + + ++ L A ++ D +K+ L + Sbjct: 5 YFRRTDNSSYRDRIPLRIVRAESELSTQEKSYLSAVEKGDYASVKLALEEAEIYFKININ 64 Query: 74 QRGAVGETALHVAALYDNLEAATLLMEAAPELAKEPALCEPFVGQTALHIAVMNQNLNLV 133 +G TAL +A +NLE LL+ +VG LH A+ + + V Sbjct: 65 CIDPLGRTALLIAIENENLEIIELLLS-----------FNVYVGDALLH-AIRKEVVGAV 112 Query: 134 RALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVRLLIEHGADIRAQD 193 LL + + P+ AA + EI+++L++ G + Sbjct: 113 ELLLNHKKPSGEKQVPPILLDKQFSDFTPDITPIILAAHTNNYEIIKMLVQKGVSVPQPH 172 Query: 194 SLGNTVLHILILQPNKTFACQMYNLLLSYDEHSDHLQSLELVPNHQG-LTPFKLAGVEGN 252 + + + + + L Y + SL + + LT F+L+ Sbjct: 173 EVRCNCVE-CVSSSDVDSLRHSRSRLNIYKALASP--SLIALSSEDPFLTAFQLSWELQE 229 Query: 253 TVMFQHLMQKR-KHVQWTCGPLTSTLYD-------LTEIDSWGEELSFLELVVSSK---- 300 ++ + + + C L D L I ++ ++++ L+ +++ Sbjct: 230 LSKVENEFKAEYEELSHQCKHFAKDLLDQTRSSRELELILNFRDDMNLLQDEANNELARL 289 Query: 301 ----KREARQILEQTPVKELVSFKWKK------------------YGRPYFCVLASLYIL 338 K ++ + Q ++L++ +W + F +L+ Y++ Sbjct: 290 KLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAGKLITCVFIGLMFPLLSLCYLV 349 Query: 339 Y---------------MICFTTCCIYRPLKLRDDNRTDPRDITILQQKLLQEAYVTHQDN 383 IC T Y + ++ + V Sbjct: 350 APKSRYGLFIRKPFIKFICHT--ASYLTFLFLLLLASQHIVSNNPDRQGPKPTTV----- 402 Query: 384 IRLVGELVTVTGAVIILLLEIPDIFRVGASRYF--GQTILGGPFHVIIITYASLVLLTMV 441 E + + + + EI ++ G Y ++ + + + SL ++ V Sbjct: 403 -----EWMILPWVLGFIWTEIKQMWDGGFQDYIHDWWNLMDFVMNSLYLATISLKIVAYV 457 Query: 442 MR-----LTNMNGEVVPLSFALVLGWCSVMYFAR------GFQMLGPFTIMIQKMIFGDL 490 L V ++ R LGP I + +M+ D+ Sbjct: 458 KYSGCKPRDTWEMWHPTLVAEAVFAIANIFSSLRLISLFTANSHLGPLQISLGRMLL-DI 516 Query: 491 MRFCWLMAVVILGFASAFH-ITFQTEDPNNLG-------EFSDYPTALFSTFELFLTIID 542 ++F ++ +V+L FA+ + + F E+ + ++ + LF T + I Sbjct: 517 LKFLFIYCLVLLAFANGLNQLYFYYENSEGMTCKGIRCERQNNAFSTLFETLQSLFWSIF 576 Query: 543 GPANYSVD--------LPFMYCITYAAFAIIATLLMLNLFIAMMGDTHWRVAQERDELWR 594 G + V F+ + + +I+ +++LN+ IAMM +++ +A D W+ Sbjct: 577 GLISLYVTNVKADHKFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQHIADHADIEWK 636 Query: 595 AQV 597 Sbjct: 637 FAR 639 >3B7B-A nrPDB Length = 237 Score = 173 bits (439), Expect = 2e-43, Method: Composition-based stats. Identities = 51/251 (20%), Positives = 92/251 (36%), Gaps = 32/251 (12%) Query: 36 VNMLQQERIRDSPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAA 95 +N + + + SPL AA+ + + +L+ + T L AA ++LEA Sbjct: 2 MNFKMEHQNKRSPLHAAAEAGHVDICHMLVQA-GANIDTCSEDQRTPLMEAAENNHLEAV 60 Query: 96 TLLMEAAPELAKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGA-SVSARATGAAFRR 154 L++A + + G T LH+A + +V+ LL+ G V+ + G Sbjct: 61 KYLIKAGALVD-----PKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDG----- 110 Query: 155 SPHNLIYYGEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQ 214 G P+ +A ++V+LL+ G+DI +D+ N LH A Sbjct: 111 --------GWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIA-- 160 Query: 215 MYNLLLSYDEHSDHLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLT 274 +LL+ + N G +P +A E + + V Sbjct: 161 --EILLAAKCDLHAV-------NIHGDSPLHIAARENRYDCVVLFLSRDSDVTLK-NKEG 210 Query: 275 STLYDLTEIDS 285 T ++S Sbjct: 211 ETPLQCASLNS 221 >6BY9-A nrPDB Length = 328 Score = 172 bits (436), Expect = 5e-43, Method: Composition-based stats. Identities = 51/250 (20%), Positives = 91/250 (36%), Gaps = 32/250 (12%) Query: 37 NMLQQERIRDSPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAAT 96 N + + + SPL AA+ + + +L+ + T L AA ++LEA Sbjct: 94 NFKMEHQNKRSPLHAAAEAGHVDICHMLVQA-GANIDTCSEDQRTPLMEAAENNHLEAVK 152 Query: 97 LLMEAAPELAKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGA-SVSARATGAAFRRS 155 L++A + + G T LH+A + +V+ LL+ G V+ + G Sbjct: 153 YLIKAGALVD-----PKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDG------ 201 Query: 156 PHNLIYYGEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQM 215 G P+ +A ++V+LL+ G+DI +D+ N LH A Sbjct: 202 -------GWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIA--- 251 Query: 216 YNLLLSYDEHSDHLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLTS 275 +LL+ + N G +P +A E + + V Sbjct: 252 -EILLAAKCDLHAV-------NIHGDSPLHIAARENRYDCVVLFLSRDSDVTLK-NKEGE 302 Query: 276 TLYDLTEIDS 285 T ++S Sbjct: 303 TPLQCASLNS 312 Score = 67.8 bits (164), Expect = 2e-11, Method: Composition-based stats. Identities = 27/157 (17%), Positives = 48/157 (30%), Gaps = 22/157 (14%) Query: 121 LHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVR 180 L+ + L V +L G + + PL AA G +I Sbjct: 71 LYFSARQGELQKVLLMLVDGIDPN------FKMEHQNK-----RSPLHAAAEAGHVDICH 119 Query: 181 LLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHSDHLQSLELVPNHQG 240 +L++ GA+I T L + + L+ D + +G Sbjct: 120 MLVQAGANIDTCSEDQRTPLMEAAENNH----LEAVKYLIKAGALVDPKDA-------EG 168 Query: 241 LTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLTSTL 277 T LA +G+ + Q+L+ + T Sbjct: 169 STCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTP 205 Score = 30.5 bits (67), Expect = 3.0, Method: Composition-based stats. Identities = 11/71 (15%), Positives = 26/71 (36%), Gaps = 3/71 (4%) Query: 214 QMYNLLLSYDEHSDHLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPL 273 ++ +LL + D +E + +P A G+ + L+Q ++ Sbjct: 79 ELQKVLLMLVDGIDPNFKME---HQNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQ 135 Query: 274 TSTLYDLTEID 284 + L + E + Sbjct: 136 RTPLMEAAENN 146 >6AUN-A nrPDB Length = 752 Score = 167 bits (422), Expect = 2e-41, Method: Composition-based stats. Identities = 63/246 (25%), Positives = 98/246 (39%), Gaps = 47/246 (19%) Query: 47 SPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAP--- 103 +PL A ++ D +L L+ GETA H A DN + LL + A Sbjct: 154 TPLHLACRKGDSEILVELVQYCHAQMDVTDNKGETAFHYAVQGDNSQVLQLLGKNASAGL 213 Query: 104 -ELAKEPALCEPFVGQTALHIAVMNQNLNLVRALL-------ARGASVSARATGAAF-RR 154 ++ K+ G T LH+A +VR LL G S T F ++ Sbjct: 214 NQVNKQ--------GLTPLHLACQMGKQEMVRVLLLCNARCNVMGPSGFPIHTAMKFSQK 265 Query: 155 SPHNLIY-------------YGEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLH 201 +I YG PL +A + E+ R+L++ G D+ + + GNT LH Sbjct: 266 GCAEMIISMDSSQIHSKDPRYGASPLHWA---KNAEMARMLLKRGCDVDSTSAAGNTALH 322 Query: 202 ILILQPNKTFACQMYNLLLSYDEHSDHLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQ 261 + +++ F C M +LL+Y ++ P G TP LA + N M + L+ Sbjct: 323 VAVMR--NRFDCVM--VLLTYGANAG-------TPGEHGNTPLHLAISKDNMEMIKALIV 371 Query: 262 KRKHVQ 267 V Sbjct: 372 FGAEVD 377 Score = 80.9 bits (198), Expect = 2e-15, Method: Composition-based stats. Identities = 50/246 (20%), Positives = 89/246 (36%), Gaps = 29/246 (11%) Query: 48 PLLQAAKENDLRLLKILLLNQSCDFQQRGAV-GETALHVAALYDNLEAATLLMEAAPELA 106 P+ A K + ++++ S + G + LH A N E A +L++ ++ Sbjct: 255 PIHTAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWA---KNAEMARMLLKRGCDVD 311 Query: 107 KEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHP 166 A G TALH+AVM + V LL GA+ +G P Sbjct: 312 STSAA-----GNTALHVAVMRNRFDCVMVLLTYGAN-------------AGTPGEHGNTP 353 Query: 167 LSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHS 226 L A + E+++ LI GA++ + G T + + Q+ +L+ Sbjct: 354 LHLAISKDNMEMIKALIVFGAEVDTPNDFGETPAFMA-----SKISKQLQDLMPISRAR- 407 Query: 227 DHLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLTSTLYDLTEIDSW 286 L + + + + L G ++Q ++ G T L+D S Sbjct: 408 KPAFILSSMRDEKRIHDHLLCLDGGGVKGL-VIIQLLIAIEKASGVATKDLFDWVAGTST 466 Query: 287 GEELSF 292 G L+ Sbjct: 467 GGILAL 472 Score = 36.2 bits (82), Expect = 0.046, Method: Composition-based stats. Identities = 26/149 (17%), Positives = 47/149 (31%), Gaps = 15/149 (10%) Query: 199 VLHILILQPNKTFACQ-----MYNLLLSYDEHSDHLQS-----LELVPNHQGLTPFKLAG 248 VLH+ +LQ + +L + S N +G TP LA Sbjct: 101 VLHVEVLQHLSDLIRSHPSWTVTHLAVELGIRECFHHSRIISCANSTENEEGCTPLHLAC 160 Query: 249 VEGNTVMFQHLMQKRKHVQWTCGPLTSTLYDLTEIDSWGEELSFLELVVSSKKREARQIL 308 +G++ + L+Q T + G+ L+L+ + Q+ Sbjct: 161 RKGDSEILVELVQYCHAQMDVTDNKGETAFHYA---VQGDNSQVLQLLGKNASAGLNQVN 217 Query: 309 EQ--TPVKELVSFKWKKYGRPYFCVLASL 335 +Q TP+ ++ R A Sbjct: 218 KQGLTPLHLACQMGKQEMVRVLLLCNARC 246 >5Z96-A nrPDB Length = 755 Score = 162 bits (410), Expect = 5e-40, Method: Composition-based stats. Identities = 103/667 (15%), Positives = 218/667 (32%), Gaps = 116/667 (17%) Query: 19 LISWPVGEQDWEQYRDRVNML-----QQERIRDSPLLQAAKENDLRLLKILLL----NQS 69 + + YRDR+ + + + L A ++ D +K L Sbjct: 1 MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFK 60 Query: 70 CDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELAKEPALCEPFVGQTALHIAVMNQN 129 + +G TAL +A EL + +VG LH A+ + Sbjct: 61 ININCIDPLGRTALLIAIEN-----------ENLELIELLLSFNVYVGDALLH-AIRKEV 108 Query: 130 LNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVRLLIEHGADI 189 + V LL + + P+ AA + EI++LL++ G + Sbjct: 109 VGAVELLLNHKKPSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSV 168 Query: 190 RAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHSDHLQSLELVPNHQG-LTPFKLAG 248 + + + + + L Y + SL + + LT F+L+ Sbjct: 169 PRPHEVRCNCVE-CVSSSDVDSLRHSRSRLNIYKALASP--SLIALSSEDPFLTAFQLSW 225 Query: 249 VEGNTVMFQHLMQKR-KHVQWTCGPLTSTLYD-------LTEIDSWGEELSFLELVVSSK 300 ++ + + + C L D L I ++ ++ S +E + Sbjct: 226 ELQELSKVENEFKSEYEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLIEEQSGND 285 Query: 301 --------KREARQILEQTPVKELVSFKW-KKYGRPY-----------------FCVLAS 334 K ++ + Q ++L++ +W ++ F V + Sbjct: 286 LARLKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSV 345 Query: 335 LYILY---------------MICFTTCCIYRPLKLRDDNRTDPRDITILQQKLLQEAYVT 379 Y++ IC T Y + D + L ++ V Sbjct: 346 CYLIAPKSPLGLFIRKPFIKFICHT--ASYLTFLFLLLLASQHIDRSDLNRQGPPPTIV- 402 Query: 380 HQDNIRLVGELVTVTGAVIILLLEIPDIFRVGASRYF--GQTILGGPFHVIIITYASLVL 437 E + + + + EI ++ G Y ++ + + + SL + Sbjct: 403 ---------EWMILPWVLGFIWGEIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKI 453 Query: 438 LTMVMRLT-----NMNGEVVPLSFALVLGWCSVMYFAR------GFQMLGPFTIMIQKMI 486 + V + + L + ++ R LGP I + +M+ Sbjct: 454 VAFVKYSALNPRESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRML 513 Query: 487 FGDLMRFCWLMAVVILGFASAFH-ITFQTEDPNNLG-------EFSDYPTALFSTFELFL 538 D+++F ++ +V+L FA+ + + F E+ L + ++ + LF T + Sbjct: 514 L-DILKFLFIYCLVLLAFANGLNQLYFYYEETKGLSCKGIRCEKQNNAFSTLFETLQSLF 572 Query: 539 TIIDGPANYSVD--------LPFMYCITYAAFAIIATLLMLNLFIAMMGDTHWRVAQERD 590 I G N V F+ + + +I+ +++LN+ IAMM +++ +A D Sbjct: 573 WSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHAD 632 Query: 591 ELWRAQV 597 W+ Sbjct: 633 IEWKFAR 639 >4Z68-A nrPDB Length = 155 Score = 161 bits (408), Expect = 9e-40, Method: Composition-based stats. Identities = 46/174 (26%), Positives = 71/174 (40%), Gaps = 23/174 (13%) Query: 46 DSPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPEL 105 D LL+AAK D+ +K L QS + + T LH AA Y+ + L++ ++ Sbjct: 4 DRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADV 63 Query: 106 AKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEH 165 + G LH A + + L+ GA V+ Sbjct: 64 -----HAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKF-------------T 105 Query: 166 PLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLL 219 PL AA G EI +LL++HGAD ++ GNT L ++ K + +LL Sbjct: 106 PLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLV-----KDGDTDIQDLL 154 Score = 80.1 bits (196), Expect = 3e-15, Method: Composition-based stats. Identities = 37/173 (21%), Positives = 58/173 (33%), Gaps = 25/173 (14%) Query: 121 LHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVR 180 L A ++ V+ L SV+ R PL FAA +V Sbjct: 7 LLEAAKAGDVETVKKLCTV-QSVNCRDIEGRQS-----------TPLHFAAGYNRVSVVE 54 Query: 181 LLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHSDHLQSLELVPNHQG 240 L++HGAD+ A+D G LH + A LL+ + + + Sbjct: 55 YLLQHGADVHAKDKGGLVPLHNACSYGHYEVA----ELLVKHGAVVNVADLWK------- 103 Query: 241 LTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLTSTLYDLTEIDSWGEELSFL 293 TP A +G + + L+Q +T DL + D + L Sbjct: 104 FTPLHEAAAKGKYEICKLLLQHGADPT-KKNRDGNTPLDLVK-DGDTDIQDLL 154 >5GP7-A nrPDB Length = 169 Score = 158 bits (399), Expect = 9e-39, Method: Composition-based stats. Identities = 42/158 (26%), Positives = 68/158 (43%), Gaps = 18/158 (11%) Query: 46 DSPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPEL 105 D+ LL AAK+ L ++ L ++ + + T LH+AA Y+NLE A L+E ++ Sbjct: 10 DAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADV 69 Query: 106 AKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEH 165 + G LH A ++++ L+ V+A A Sbjct: 70 NAQDK-----GGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAF-------------T 111 Query: 166 PLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHIL 203 PL AA G ++ LL+ HGAD ++ G T L + Sbjct: 112 PLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLA 149 Score = 85.2 bits (209), Expect = 8e-17, Method: Composition-based stats. Identities = 40/173 (23%), Positives = 56/173 (32%), Gaps = 24/173 (13%) Query: 112 CEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAA 171 + G AL A L V+ L +++ R T PL AA Sbjct: 4 SDLLRGDAALLDAAKKGCLARVQKLCTP-ENINCRDTQGRNS-----------TPLHLAA 51 Query: 172 CVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHSDHLQS 231 + E+ L+EHGAD+ AQD G LH + A LL+ Y+ + Sbjct: 52 GYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAA----LLIKYNTCVNATDK 107 Query: 232 LELVPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLTSTLYDLTEID 284 TP A +G T + L+ T DL D Sbjct: 108 W-------AFTPLHEAAQKGRTQLCALLLAHGADPT-MKNQEGQTPLDLATAD 152 Score = 75.9 bits (185), Expect = 6e-14, Method: Composition-based stats. Identities = 33/125 (26%), Positives = 45/125 (36%), Gaps = 19/125 (15%) Query: 47 SPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELA 106 +PL AA N+L + + LL D + G LH AA Y +++ A LL++ + Sbjct: 45 TPLHLAAGYNNLEVAEYLLE-HGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVN 103 Query: 107 KEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHP 166 T LH A L LLA GA P G+ P Sbjct: 104 -----ATDKWAFTPLHEAAQKGRTQLCALLLAHGAD-------------PTMKNQEGQTP 145 Query: 167 LSFAA 171 L A Sbjct: 146 LDLAT 150 Score = 39.7 bits (91), Expect = 0.004, Method: Composition-based stats. Identities = 13/44 (29%), Positives = 22/44 (50%), Gaps = 1/44 (2%) Query: 47 SPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYD 90 +PL +AA++ +L +LL D + G+T L +A D Sbjct: 111 TPLHEAAQKGRTQLCALLLA-HGADPTMKNQEGQTPLDLATADD 153 >4O1O-A nrPDB Length = 717 Score = 150 bits (379), Expect = 2e-36, Method: Composition-based stats. Identities = 60/248 (24%), Positives = 95/248 (38%), Gaps = 24/248 (9%) Query: 24 VGEQDWEQYRD------RVNMLQQERIRDSPLLQAAKENDLRLLKILLLNQSCDFQQRGA 77 V E D EQ R N ++E SPL A + D L LLL D R Sbjct: 16 VQEADIEQVRQLLERGADANFQEEEWGW-SPLHSAVQM-DSEDLVALLLKHGADPCLRKR 73 Query: 78 VGETALHVAALYDNLEAATLLMEAAPELAKEPALCEPFVGQTALHIAVMNQNLNLVRALL 137 G T +A + N+ LL+ ++ + G TA A + + +R L Sbjct: 74 NGATPFIIAGITGNVRLLQLLLPNVEDVNECDVN-----GFTAFMEAAVYGRVEALRFLY 128 Query: 138 ARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVRLLI-EHGADIRAQDSLG 196 GA V+ ++ + G L AA G +V +L+ A++ A+D++G Sbjct: 129 ENGADVNMHRKT---KQDQERIRKGGATALMDAAEKGHVGVVTILLHAMKAEVDARDNMG 185 Query: 197 NTVLHILILQPNKTFACQMYNLLLSYDEHSDHLQSLELVPNHQGLTPFKLAGVEGNTVMF 256 L +L P+ A + LLL + + V TP LA N + Sbjct: 186 RNALVYALLNPDDGKAKAITRLLLDHGADVN-------VRGEGSKTPLILAVERKNLDLV 238 Query: 257 QHLMQKRK 264 Q L+++ + Sbjct: 239 QMLLEQEQ 246 Score = 72.8 bits (177), Expect = 5e-13, Method: Composition-based stats. Identities = 45/218 (20%), Positives = 70/218 (32%), Gaps = 65/218 (29%) Query: 40 QQERIRDSPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLM 99 ++R +P + A ++RLL++LL N D + G TA AA+Y +EA L Sbjct: 70 LRKRNGATPFIIAGITGNVRLLQLLLPNVE-DVNECDVNGFTAFMEAAVYGRVEALRFLY 128 Query: 100 EAAPELAKEPALCEPFV-----GQTALHIAVMNQNLNLV--------------------- 133 E ++ + G TAL A ++ +V Sbjct: 129 ENGADVNMHRKTKQDQERIRKGGATALMDAAEKGHVGVVTILLHAMKAEVDARDNMGRNA 188 Query: 134 -----------------RALLARGASVSARATGAAF---------------------RRS 155 R LL GA V+ R G+ + Sbjct: 189 LVYALLNPDDGKAKAITRLLLDHGADVNVRGEGSKTPLILAVERKNLDLVQMLLEQEQIE 248 Query: 156 PHNLIYYGEHPLSFAACVGSEEIVRLLIEHGADIRAQD 193 ++ G+ L A + EEI +LL GA D Sbjct: 249 VNDTDREGKTALLLAVELRLEEIAKLLCHRGASTNCGD 286 Score = 55.9 bits (133), Expect = 7e-08, Method: Composition-based stats. Identities = 34/150 (22%), Positives = 56/150 (37%), Gaps = 13/150 (8%) Query: 167 LSFAACVGSEEIVRLLIEHGADIRAQDSL-GNTVLHILILQPNKTFACQMYNLLLSYDEH 225 L+ A E VR L+E GAD Q+ G + LH + ++ LLL + Sbjct: 12 LTQAVQEADIEQVRQLLERGADANFQEEEWGWSPLHSAVQMDSEDLVA----LLLKHGAD 67 Query: 226 SDHLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLTSTLYDLTEIDS 285 + G TPF +AG+ GN + Q L+ + V T + + Sbjct: 68 PC-------LRKRNGATPFIIAGITGNVRLLQLLLPNVEDVNEC-DVNGFTAFMEAAVYG 119 Query: 286 WGEELSFLELVVSSKKREARQILEQTPVKE 315 E L FL + + +Q +++ Sbjct: 120 RVEALRFLYENGADVNMHRKTKQDQERIRK 149 Score = 43.9 bits (102), Expect = 3e-04, Method: Composition-based stats. Identities = 25/130 (19%), Positives = 44/130 (33%), Gaps = 17/130 (13%) Query: 46 DSPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPEL 105 +PL+ A + +L L+++LL + + G+TAL +A E A LL Sbjct: 223 KTPLILAVERKNLDLVQMLLEQEQIEVNDTDREGKTALLLAVELRLEEIAKLLCHRGAST 282 Query: 106 AKEPALCEPFVGQTALHIAVMNQNL--NLVRALLARGASVSARATGAAFRRSPHNLIYYG 163 +A+ +N +LV+ L A R ++ +G Sbjct: 283 NCGDL------------VAIARRNYDSDLVKFLRLHKAGEDFRPPAENWKPQSSR---WG 327 Query: 164 EHPLSFAACV 173 E Sbjct: 328 EALKHLHRIW 337 >5JHQ-A nrPDB Length = 482 Score = 141 bits (355), Expect = 1e-33, Method: Composition-based stats. Identities = 51/279 (18%), Positives = 91/279 (32%), Gaps = 31/279 (11%) Query: 47 SPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELA 106 LL+A + D+ +K L+ + + + + LH AA + + L++ + Sbjct: 17 RELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANV- 75 Query: 107 KEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHP 166 G LH A + +V LL +GA +AR P Sbjct: 76 ----HARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNY-------------TP 118 Query: 167 LSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHS 226 L AA G ++ +L++HGAD +++ G + L + + L S Sbjct: 119 LHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARS 178 Query: 227 DHLQSLELV----------PNHQGLTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLTST 276 + + L + + + TP LA + Q L+Q V Sbjct: 179 GNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVH-AKDKGGLV 237 Query: 277 LYDLTEIDSWGEELSFLELVVSSKKREARQILEQTPVKE 315 E L + A + + TP+ E Sbjct: 238 PLHNACSYGHYEVTELL--LKHGACVNAMDLWQFTPLHE 274 Score = 140 bits (353), Expect = 2e-33, Method: Composition-based stats. Identities = 50/286 (17%), Positives = 84/286 (29%), Gaps = 79/286 (27%) Query: 45 RDSPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPE 104 + LL+AA+ + L LL + + T LH+AA Y+ + LL++ + Sbjct: 168 KKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGAD 227 Query: 105 LAKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGE 164 + + G LH A + + LL GA V+A Sbjct: 228 V-----HAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQF------------- 269 Query: 165 HPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQP----------------- 207 PL AA E+ LL+ HGAD + G + + + Sbjct: 270 TPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQA 329 Query: 208 ---------NKTFACQM---------------------------YNLLLSYDEHSDHLQS 231 KT A ++ LLL + + Sbjct: 330 AREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNE--- 386 Query: 232 LELVPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLTSTL 277 N +TP +A + + + L + + L T Sbjct: 387 ----KNKDFMTPLHVAAERAHNDVMEVLHKHGAKMN-ALDTLGQTA 427 Score = 125 bits (313), Expect = 9e-29, Method: Composition-based stats. Identities = 52/271 (19%), Positives = 83/271 (30%), Gaps = 58/271 (21%) Query: 36 VNMLQQERIRDSPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAA 95 VN + SPL AA +++ LL + R G LH A + + E Sbjct: 40 VNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQ-MGANVHARDDGGLIPLHNACSFGHAEVV 98 Query: 96 TLLMEAAPELAKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAA---- 151 +LL+ + T LH A + +++ LL GA + R T Sbjct: 99 SLLLCQGADPN-----ARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALD 153 Query: 152 -------------------------------------FRRSPHNLIYYGEHPLSFAACVG 174 + H PL AA Sbjct: 154 LADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYN 213 Query: 175 SEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHSDHLQSLEL 234 IV+LL++HGAD+ A+D G LH + ++ LLL + + + + Sbjct: 214 RVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGH----YEVTELLLKHGACVNAMDLWQ- 268 Query: 235 VPNHQGLTPFKLAGVEGNTVMFQHLMQKRKH 265 TP A + + L+ Sbjct: 269 ------FTPLHEAASKNRVEVCSLLLSHGAD 293 Score = 111 bits (277), Expect = 1e-24, Method: Composition-based stats. Identities = 47/265 (17%), Positives = 83/265 (31%), Gaps = 61/265 (23%) Query: 45 RDSPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPE 104 + +PL AA N +R++++LL D + G LH A Y + E LL++ Sbjct: 202 KSTPLHLAAGYNRVRIVQLLLQ-HGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGAC 260 Query: 105 LAKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGAS---VSARATGAAFRRSPHNLI- 160 + T LH A + + LL+ GA V+ A L Sbjct: 261 VN-----AMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRE 315 Query: 161 -----YYG--------------------------------EHPLSFAACVGSE---EIVR 180 + G E L A ++ Sbjct: 316 RLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTE 375 Query: 181 LLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHSDHLQSLELVPNHQG 240 LL+ GA++ ++ T LH+ + + + +L + + L +L G Sbjct: 376 LLLRKGANVNEKNKDFMTPLHVAAERAHND----VMEVLHKHGAKMNALDTL-------G 424 Query: 241 LTPFKLAGVEGNTVMFQHLMQKRKH 265 T A + G+ + L+ Sbjct: 425 QTALHRAALAGHLQTCRLLLSYGSD 449 Score = 94.4 bits (233), Expect = 2e-19, Method: Composition-based stats. Identities = 56/266 (21%), Positives = 82/266 (30%), Gaps = 82/266 (30%) Query: 48 PLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPE--- 104 PL A + LLL T LH AA + +E +LL+ + Sbjct: 238 PLHNACSYGHYE-VTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTL 296 Query: 105 LAKEPALCEP--------------FVGQ-------------------------------- 118 + F G Sbjct: 297 VNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHE 356 Query: 119 TALHIAVMNQN---LNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGS 175 TALH AV + + + LL +GA+V+ + PL AA Sbjct: 357 TALHCAVASLHPKRKQVTELLLRKGANVNEKNKDF-------------MTPLHVAAERAH 403 Query: 176 EEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHSDHLQSLELV 235 +++ +L +HGA + A D+LG T LH L + Q LLLSY + Sbjct: 404 NDVMEVLHKHGAKMNALDTLGQTALHRAALAGH----LQTCRLLLSYGSD-------PSI 452 Query: 236 PNHQGLTPFKLAGVEGNTVMFQHLMQ 261 + QG T A GN Q ++ Sbjct: 453 ISLQGFT----AAQMGN-EAVQQILS 473 Score = 55.9 bits (133), Expect = 6e-08, Method: Composition-based stats. Identities = 23/104 (22%), Positives = 42/104 (40%), Gaps = 10/104 (9%) Query: 33 RDRVNMLQQERIRDSPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNL 92 R N+ ++ + +PL AA+ ++++L +G+TALH AAL +L Sbjct: 379 RKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHK-HGAKMNALDTLGQTALHRAALAGHL 437 Query: 93 EAATLLMEAAPELAKEPALCEPFVGQTALHIAVMNQNLNLVRAL 136 + LL+ + + G T A N + + L Sbjct: 438 QTCRLLLSYGSDPSIIS-----LQGFT----AAQMGNEAVQQIL 472 Score = 29.3 bits (64), Expect = 5.8, Method: Composition-based stats. Identities = 15/58 (25%), Positives = 22/58 (37%), Gaps = 5/58 (8%) Query: 46 DSPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAP 103 + L +AA L+ ++LL D G T AA N +L E+ P Sbjct: 425 QTALHRAALAGHLQTCRLLLSY-GSDPSIISLQGFT----AAQMGNEAVQQILSESTP 477 >5HKP-A nrPDB Length = 351 Score = 139 bits (350), Expect = 4e-33, Method: Composition-based stats. Identities = 51/286 (17%), Positives = 85/286 (29%), Gaps = 79/286 (27%) Query: 45 RDSPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPE 104 + LL+AA+ + L LL + + T LH+AA Y+ + LL++ + Sbjct: 24 KKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGAD 83 Query: 105 LAKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGE 164 + + G LH A + + LL GA V+A Sbjct: 84 V-----HAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQF------------- 125 Query: 165 HPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQP----------------- 207 PL AA E+ LL+ HGAD + G + + + Sbjct: 126 TPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQA 185 Query: 208 ---------NKTFACQMYN---------------------------LLLSYDEHSDHLQS 231 KT A ++ N LLL + + Sbjct: 186 AREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVAELLLRKGANVNE--- 242 Query: 232 LELVPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLTSTL 277 N +TP +A + + + L + + L T Sbjct: 243 ----KNKDFMTPLHVAAERAHNDVMEVLHKHGAKMN-ALDSLGQTA 283 Score = 110 bits (276), Expect = 1e-24, Method: Composition-based stats. Identities = 47/265 (17%), Positives = 81/265 (30%), Gaps = 61/265 (23%) Query: 45 RDSPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPE 104 + +PL AA N +R++++LL D + G LH A Y + E LL++ Sbjct: 58 KSTPLHLAAGYNRVRIVQLLLQ-HGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGAC 116 Query: 105 LAKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGAS---VSARATGAAFRRSPHNLI- 160 + T LH A + + LL+ GA V+ A L Sbjct: 117 VN-----AMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRE 171 Query: 161 -------------------------------------YYGEHPLSFAACVGSE---EIVR 180 E L A ++ Sbjct: 172 RLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVAE 231 Query: 181 LLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHSDHLQSLELVPNHQG 240 LL+ GA++ ++ T LH+ + + + +L + + L SL G Sbjct: 232 LLLRKGANVNEKNKDFMTPLHVAAERAHND----VMEVLHKHGAKMNALDSL-------G 280 Query: 241 LTPFKLAGVEGNTVMFQHLMQKRKH 265 T A + G+ + L+ Sbjct: 281 QTALHRAALAGHLQTCRLLLSYGSD 305 Score = 95.2 bits (235), Expect = 1e-19, Method: Composition-based stats. Identities = 57/266 (21%), Positives = 82/266 (30%), Gaps = 82/266 (30%) Query: 48 PLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPE--- 104 PL A + LLL T LH AA + +E +LL+ + Sbjct: 94 PLHNACSYGHYE-VTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTL 152 Query: 105 LAKEPALCEP--------------FVGQ-------------------------------- 118 + F G Sbjct: 153 VNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHE 212 Query: 119 TALHIAVMNQN---LNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGS 175 TALH AV + + + LL +GA+V+ + PL AA Sbjct: 213 TALHCAVASLHPKRKQVAELLLRKGANVNEKNKDF-------------MTPLHVAAERAH 259 Query: 176 EEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHSDHLQSLELV 235 +++ +L +HGA + A DSLG T LH L + Q LLLSY + Sbjct: 260 NDVMEVLHKHGAKMNALDSLGQTALHRAALAGH----LQTCRLLLSYGSD-------PSI 308 Query: 236 PNHQGLTPFKLAGVEGNTVMFQHLMQ 261 + QG T A GN Q ++ Sbjct: 309 ISLQGFT----AAQMGN-EAVQQILS 329 Score = 56.3 bits (134), Expect = 4e-08, Method: Composition-based stats. Identities = 23/104 (22%), Positives = 43/104 (41%), Gaps = 10/104 (9%) Query: 33 RDRVNMLQQERIRDSPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNL 92 R N+ ++ + +PL AA+ ++++L ++G+TALH AAL +L Sbjct: 235 RKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHK-HGAKMNALDSLGQTALHRAALAGHL 293 Query: 93 EAATLLMEAAPELAKEPALCEPFVGQTALHIAVMNQNLNLVRAL 136 + LL+ + + G T A N + + L Sbjct: 294 QTCRLLLSYGSDPSIIS-----LQGFT----AAQMGNEAVQQIL 328 Score = 33.2 bits (74), Expect = 0.38, Method: Composition-based stats. Identities = 19/131 (14%), Positives = 33/131 (25%), Gaps = 13/131 (9%) Query: 195 LGNTVLHILILQPNKTFACQMYNLLLSYDEHSDHLQSLELV----------PNHQGLTPF 244 G + L + + L S + + L + + + TP Sbjct: 3 FGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPL 62 Query: 245 KLAGVEGNTVMFQHLMQKRKHVQWTCGPLTSTLYDLTEIDSWGEELSFLELVVSSKKREA 304 LA + Q L+Q V E L + A Sbjct: 63 HLAAGYNRVRIVQLLLQHGADVH-AKDKGGLVPLHNACSYGHYEVTELL--LKHGACVNA 119 Query: 305 RQILEQTPVKE 315 + + TP+ E Sbjct: 120 MDLWQFTPLHE 130 Score = 29.3 bits (64), Expect = 6.3, Method: Composition-based stats. Identities = 15/58 (25%), Positives = 22/58 (37%), Gaps = 5/58 (8%) Query: 46 DSPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAP 103 + L +AA L+ ++LL D G T AA N +L E+ P Sbjct: 281 QTALHRAALAGHLQTCRLLLSY-GSDPSIISLQGFT----AAQMGNEAVQQILSESTP 333 >5CBO-A nrPDB Length = 176 Score = 132 bits (331), Expect = 7e-31, Method: Composition-based stats. Identities = 44/171 (25%), Positives = 67/171 (39%), Gaps = 32/171 (18%) Query: 83 LHVAALYDNLEAATLLMEAAPELAKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGAS 142 L AA + +LM ++ G T LH+A + +V LL GA Sbjct: 7 LLEAAHAGQDDEVRILMANGADVN-----AMDNFGVTPLHLAAYWGHFEIVEVLLKYGAD 61 Query: 143 VSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHI 202 V+A G+ PL AA G IV +L+++GAD+ AQD G T I Sbjct: 62 VNASDAT-------------GDTPLHLAAKWGYLGIVEVLLKYGADVNAQDKFGKTAFDI 108 Query: 203 LILQPNKT--------------FACQMYNLLLSYDEHSDHLQSLELVPNHQ 239 I N+ F C ++ L+ + + +QSL+ P+ Sbjct: 109 SIDNGNEDLAEILCKNKAQQAAFYCILHMPNLNEAQRNGFIQSLKDDPSQS 159 Score = 95.6 bits (236), Expect = 7e-20, Method: Composition-based stats. Identities = 36/138 (26%), Positives = 65/138 (47%), Gaps = 15/138 (10%) Query: 167 LSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHS 226 L AA G ++ VR+L+ +GAD+ A D+ G T LH+ + ++ +LL Y Sbjct: 7 LLEAAHAGQDDEVRILMANGADVNAMDNFGVTPLHLAAYWGH----FEIVEVLLKYGADV 62 Query: 227 DHLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLTSTLYDLTEIDSW 286 + + G TP LA G + + L++ V T +D++ ID+ Sbjct: 63 NASDA-------TGDTPLHLAAKWGYLGIVEVLLKYGADVN-AQDKFGKTAFDIS-IDNG 113 Query: 287 GEELSFLELVVSSKKREA 304 E+L+ E++ +K ++A Sbjct: 114 NEDLA--EILCKNKAQQA 129 Score = 46.2 bits (108), Expect = 5e-05, Method: Composition-based stats. Identities = 16/59 (27%), Positives = 29/59 (49%), Gaps = 1/59 (1%) Query: 46 DSPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPE 104 D+PL AAK L ++++LL D + G+TA ++ N + A +L + + Sbjct: 70 DTPLHLAAKWGYLGIVEVLLKY-GADVNAQDKFGKTAFDISIDNGNEDLAEILCKNKAQ 127 >2DWZ-A nrPDB Length = 231 Score = 116 bits (291), Expect = 3e-26, Method: Composition-based stats. Identities = 52/214 (24%), Positives = 83/214 (38%), Gaps = 29/214 (13%) Query: 53 AKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELAKEPALC 112 A L LK +L + TALH A + E L++ + + Sbjct: 14 AYSGKLDELKERILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDA- 72 Query: 113 EPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAAC 172 G + LHIA +V+ALL +GA V+A G PL +AA Sbjct: 73 ----GWSPLHIAASAGRDEIVKALLVKGAHVNAVNQN-------------GCTPLHYAAS 115 Query: 173 VGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHSDHLQSL 232 EI +L+E GA+ A+D T +H + N +M ++LL Y ++ Sbjct: 116 KNRHEIAVMLLEGGANPDAKDHYDATAMHRAAAKGN----LKMVHILLFYKASTN----- 166 Query: 233 ELVPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHV 266 + + +G TP LA E + L+ + + Sbjct: 167 --IQDTEGNTPLHLACDEERVEEAKFLVTQGASI 198 Score = 113 bits (282), Expect = 3e-25, Method: Composition-based stats. Identities = 42/214 (19%), Positives = 74/214 (34%), Gaps = 32/214 (14%) Query: 43 RIRDSPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAA 102 + + L A +++ LL + G + LH+AA E L+ Sbjct: 38 QDSRTALHWACSAGHTEIVEFLLQL-GVPVNDKDDAGWSPLHIAASAGRDEIVKALLVKG 96 Query: 103 PELAKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYY 162 + G T LH A + LL GA+ A+ +Y Sbjct: 97 AHVNAVNQN-----GCTPLHYAASKNRHEIAVMLLEGGANPDAKD-------------HY 138 Query: 163 GEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSY 222 + AA G+ ++V +L+ + A QD+ GNT LH+ + A L++ Sbjct: 139 DATAMHRAAAKGNLKMVHILLFYKASTNIQDTEGNTPLHLACDEERVEEA----KFLVTQ 194 Query: 223 DEHSDHLQSLELVPNHQGLTPFKLAGVEGNTVMF 256 + N + TP ++A +G + Sbjct: 195 GASIY-------IENKEEKTPLQVA--KGGLGLI 219 Score = 95.2 bits (235), Expect = 9e-20, Method: Composition-based stats. Identities = 50/209 (23%), Positives = 75/209 (35%), Gaps = 27/209 (12%) Query: 106 AKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEH 165 K A +TALH A + +V LL G V+ + G Sbjct: 29 DKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDA-------------GWS 75 Query: 166 PLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEH 225 PL AA G +EIV+ L+ GA + A + G T LH + A +LL + Sbjct: 76 PLHIAASAGRDEIVKALLVKGAHVNAVNQNGCTPLHYAASKNRHEIAV----MLLEGGAN 131 Query: 226 SDHLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLTSTLYDLTEIDS 285 D + T A +GN M L+ + +T L + Sbjct: 132 PDAKDHYDA-------TAMHRAAAKGNLKMVHILLFYKASTN-IQDTEGNTPLHLACDEE 183 Query: 286 WGEELSFLELVVSSKKREARQILEQTPVK 314 EE FL +S E ++ E+TP++ Sbjct: 184 RVEEAKFLVTQGASIYIENKE--EKTPLQ 210 >4NIK-A nrPDB Length = 230 Score = 116 bits (290), Expect = 4e-26, Method: Composition-based stats. Identities = 52/214 (24%), Positives = 83/214 (38%), Gaps = 29/214 (13%) Query: 53 AKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELAKEPALC 112 A L LK +L + TALH A + E L++ + + Sbjct: 18 AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDA- 76 Query: 113 EPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAAC 172 G + LHIA +V+ALL +GA V+A G PL +AA Sbjct: 77 ----GWSPLHIAASAGRDEIVKALLGKGAQVNAVNQN-------------GCTPLHYAAS 119 Query: 173 VGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHSDHLQSL 232 EI +L+E GA+ A+D T +H + N +M ++LL Y ++ Sbjct: 120 KNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGN----LKMIHILLYYKASTN----- 170 Query: 233 ELVPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHV 266 + + +G TP LA E + L+ + + Sbjct: 171 --IQDTEGNTPLHLACDEERVEEAKLLVSQGASI 202 Score = 114 bits (286), Expect = 1e-25, Method: Composition-based stats. Identities = 43/214 (20%), Positives = 76/214 (35%), Gaps = 32/214 (14%) Query: 43 RIRDSPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAA 102 + + L A +++ LL + G + LH+AA E L+ Sbjct: 42 QDSRTALHWACSAGHTEIVEFLLQL-GVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 100 Query: 103 PELAKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYY 162 ++ G T LH A + LL GA+ A+ +Y Sbjct: 101 AQVNAVNQN-----GCTPLHYAASKNRHEIAVMLLEGGANPDAKD-------------HY 142 Query: 163 GEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSY 222 + AA G+ +++ +L+ + A QD+ GNT LH+ + A LL+S Sbjct: 143 EATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEA----KLLVSQ 198 Query: 223 DEHSDHLQSLELVPNHQGLTPFKLAGVEGNTVMF 256 + N + TP ++A +G + Sbjct: 199 GASIY-------IENKEEKTPLQVA--KGGLGLI 223 Score = 97.5 bits (241), Expect = 2e-20, Method: Composition-based stats. Identities = 50/216 (23%), Positives = 77/216 (35%), Gaps = 27/216 (12%) Query: 99 MEAAPELAKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHN 158 ++ + K A +TALH A + +V LL G V+ + Sbjct: 26 LKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDA--------- 76 Query: 159 LIYYGEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNL 218 G PL AA G +EIV+ L+ GA + A + G T LH + A + Sbjct: 77 ----GWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAV----M 128 Query: 219 LLSYDEHSDHLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLTSTLY 278 LL + D E T A +GN M L+ + +T Sbjct: 129 LLEGGANPDAKDHYEA-------TAMHRAAAKGNLKMIHILLYYKASTN-IQDTEGNTPL 180 Query: 279 DLTEIDSWGEELSFLELVVSSKKREARQILEQTPVK 314 L + EE L +S E ++ E+TP++ Sbjct: 181 HLACDEERVEEAKLLVSQGASIYIENKE--EKTPLQ 214 >5ET1-A nrPDB Length = 353 Score = 105 bits (262), Expect = 7e-23, Method: Composition-based stats. Identities = 48/237 (20%), Positives = 78/237 (32%), Gaps = 32/237 (13%) Query: 43 RIRDSPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAA 102 R +P AA L L+ LL C Q++ G T LH+AA + + + L+ Sbjct: 69 RNGATPAHDAAATGYLSCLQWLLTQGGCRVQEKDNSGATVLHLAARFGHPDVVKWLLYQG 128 Query: 103 PELAKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGAS-VSARATGAAFRRSPHNLIY 161 + G +H A +L ++ L+ V+A+ Sbjct: 129 ----GANSAITTDTGALPIHYAAAKGDLPSLKLLVGHYPEGVNAQTNN------------ 172 Query: 162 YGEHPLSFAACVGSEEIVRLLIEH-GADIRAQDSLGNTVLHILILQPNKTFACQMYNLLL 220 G PL A G E+ + L++ AD + G T LH + + L Sbjct: 173 -GATPLYLACQEGHLEVTKYLVQECSADPHLRAQDGMTPLHAAAQMGHNPVL-----VWL 226 Query: 221 SYDEHSDHLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHVQ---WTCGPLT 274 + +H G T A G+T + L+ + W PL Sbjct: 227 VSFADVSFSEQ-----DHDGATAMHFAASRGHTKVLSWLLLHGAEISQDLWGGTPLH 278 Score = 102 bits (254), Expect = 6e-22, Method: Composition-based stats. Identities = 40/169 (23%), Positives = 65/169 (38%), Gaps = 18/169 (10%) Query: 41 QERIRDSPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLME 100 Q +PL A +E L + K L+ S D R G T LH AA + + + Sbjct: 169 QTNNGATPLYLACQEGHLEVTKYLVQECSADPHLRAQDGMTPLHAAAQMGH-NPVLVWLV 227 Query: 101 AAPELAKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLI 160 + +++ + G TA+H A + ++ LL GA +S Sbjct: 228 SFADVSFSE---QDHDGATAMHFAASRGHTKVLSWLLLHGAEIS--------------QD 270 Query: 161 YYGEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNK 209 +G PL AA G E ++L +GA + +D G T + + Sbjct: 271 LWGGTPLHDAAENGELECCQILAVNGAGLDVRDHDGYTAADLAEFNGHT 319 Score = 98.6 bits (244), Expect = 8e-21, Method: Composition-based stats. Identities = 56/212 (26%), Positives = 88/212 (41%), Gaps = 28/212 (13%) Query: 48 PLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELAK 107 P+ AA + DL LK+L+ + + G T L++A +LE L++ E + Sbjct: 142 PIHYAAAKGDLPSLKLLVGHYPEGVNAQTNNGATPLYLACQEGHLEVTKYLVQ---ECSA 198 Query: 108 EPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPL 167 +P L G T LH A + ++ L++ A VS F H+ G + Sbjct: 199 DPHL-RAQDGMTPLHAAAQMGHNPVLVWLVSF-ADVS-------FSEQDHD----GATAM 245 Query: 168 SFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHSD 227 FAA G +++ L+ HGA+I +QD G T LH + +L D Sbjct: 246 HFAASRGHTKVLSWLLLHGAEI-SQDLWGGTPLHDAAENGE----LECCQILAVNGAGLD 300 Query: 228 HLQSLELVPNHQGLTPFKLAGVEGNTVMFQHL 259 V +H G T LA G+T ++L Sbjct: 301 -------VRDHDGYTAADLAEFNGHTHCSRYL 325 Score = 91.3 bits (225), Expect = 1e-18, Method: Composition-based stats. Identities = 49/214 (22%), Positives = 77/214 (35%), Gaps = 29/214 (13%) Query: 50 LQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELAKEP 109 LQAA+ DL +L+ L R ++ +H AA L L+E P Sbjct: 8 LQAARRGDLDVLRSLHAAGLLGPSLRDSLDALPVHHAARSGKLHCLRYLVEEVA----LP 63 Query: 110 ALCEPFVGQTALHIAVMNQNLNLVRALLARGAS-VSARATGAAFRRSPHNLIYYGEHPLS 168 A+ G T H A L+ ++ LL +G V + G L Sbjct: 64 AVSRARNGATPAHDAAATGYLSCLQWLLTQGGCRVQEKDNS-------------GATVLH 110 Query: 169 FAACVGSEEIVRLLI-EHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHSD 227 AA G ++V+ L+ + GA+ G +H + + L S Sbjct: 111 LAARFGHPDVVKWLLYQGGANSAITTDTGALPIHYAAAKGD----------LPSLKLLVG 160 Query: 228 HLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQ 261 H + G TP LA EG+ + ++L+Q Sbjct: 161 HYPEGVNAQTNNGATPLYLACQEGHLEVTKYLVQ 194 Score = 54.7 bits (130), Expect = 2e-07, Method: Composition-based stats. Identities = 27/108 (25%), Positives = 39/108 (36%), Gaps = 7/108 (6%) Query: 29 WEQYRDRVNMLQQERIRDSPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAAL 88 W V+ +Q+ + + AA ++L LLL + Q G T LH AA Sbjct: 225 WLVSFADVSFSEQDHDGATAMHFAASRGHTKVLSWLLL-HGAEISQ-DLWGGTPLHDAAE 282 Query: 89 YDNLEAATLLMEAAPELAKEPALCEPFVGQTALHIAVMNQNLNLVRAL 136 LE +L L G TA +A N + + R L Sbjct: 283 NGELECCQILAVNGAGLD-----VRDHDGYTAADLAEFNGHTHCSRYL 325 >3EU9-A nrPDB Length = 240 Score = 101 bits (251), Expect = 1e-21, Method: Composition-based stats. Identities = 52/218 (23%), Positives = 80/218 (36%), Gaps = 31/218 (14%) Query: 49 LLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELAKE 108 L AA N + L+K + + Q G + T LH A +L LM+ + + Sbjct: 46 LHWAAINNRIDLVKYYISKGAIVDQLGGDLNSTPLHWATRQGHLSMVVQLMKYGADPSLI 105 Query: 109 PALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLS 168 G + +H+A + ++V L+A+G V G PL Sbjct: 106 DG-----EGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQN-------------GMTPLM 147 Query: 169 FAACVGS-EEIVRLLIEHGADIRAQDSL-GNTVLHILILQPNKTFACQMYNLLLSYDEHS 226 +AA + RLL+ + D NT LH +L N T +LLL + Sbjct: 148 WAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTVI----SLLLEAGANV 203 Query: 227 DHLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQKRK 264 D N +G + LA N M HL + R+ Sbjct: 204 DAQ-------NIKGESALDLAKQRKNVWMINHLQEARQ 234 Score = 101 bits (251), Expect = 1e-21, Method: Composition-based stats. Identities = 34/172 (19%), Positives = 65/172 (37%), Gaps = 19/172 (11%) Query: 47 SPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELA 106 +PL A ++ L ++ L+ D G + +H+AA + + L+ ++ Sbjct: 78 TPLHWATRQGHLSMVVQLMKY-GADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVD 136 Query: 107 KEPALCEPFVGQTALHIAVMNQN-LNLVRALLARGASVSARATGAAFRRSPHNLIYYGEH 165 G T L A + ++ R LL SV+ Y+ Sbjct: 137 MMDQN-----GMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDK------------YHKNT 179 Query: 166 PLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYN 217 L +A G+ ++ LL+E GA++ AQ+ G + L + + N + Sbjct: 180 ALHWAVLAGNTTVISLLLEAGANVDAQNIKGESALDLAKQRKNVWMINHLQE 231 Score = 67.8 bits (164), Expect = 2e-11, Method: Composition-based stats. Identities = 34/168 (20%), Positives = 62/168 (36%), Gaps = 28/168 (16%) Query: 85 VAALYDNLEAATLLMEAAPELAKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVS 144 A Y E L+EA ++ + T LH A +N ++LV+ +++GA V Sbjct: 15 KATQYGIYERCRELVEAGYDVRQPDK-----ENVTLLHWAAINNRIDLVKYYISKGAIVD 69 Query: 145 ARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILI 204 PL +A G +V L+++GAD D G + +H+ Sbjct: 70 ------------QLGGDLNSTPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAA 117 Query: 205 LQPNKTFACQMYNLLLSYDEHSDHLQSLELVPNHQGLTPFKLAGVEGN 252 + + L++ + D + + G+TP A + Sbjct: 118 QFGHTSIVAY----LIAKGQDVD-------MMDQNGMTPLMWAAYRTH 154 Score = 53.6 bits (127), Expect = 3e-07, Method: Composition-based stats. Identities = 30/148 (20%), Positives = 48/148 (32%), Gaps = 31/148 (20%) Query: 124 AVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVRLLI 183 A R L+ G V L +AA ++V+ I Sbjct: 16 ATQYGIYERCRELVEAGYDVRQPDKENV-------------TLLHWAAINNRIDLVKYYI 62 Query: 184 EHGADIRAQDSLG----NTVLHILILQPNKTFACQMYNLLLSYDEHSDHLQSLELVPNHQ 239 GA + D LG +T LH Q + + Q L+ Y + + Sbjct: 63 SKGAIV---DQLGGDLNSTPLHWATRQGHLSMVVQ----LMKYGADPSLIDG-------E 108 Query: 240 GLTPFKLAGVEGNTVMFQHLMQKRKHVQ 267 G + LA G+T + +L+ K + V Sbjct: 109 GCSCIHLAAQFGHTSIVAYLIAKGQDVD 136 >3ZKJ-A nrPDB Length = 261 Score = 96.3 bits (238), Expect = 4e-20, Method: Composition-based stats. Identities = 44/222 (19%), Positives = 74/222 (33%), Gaps = 32/222 (14%) Query: 47 SPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELA 106 SP+ +AA L+ L+ Q A + LH A L +L +L++ ++ Sbjct: 5 SPMHEAAIHGHQLSLRNLIS-QGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVN 63 Query: 107 KEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHP 166 A T L A ++ + + V LL GASV + P Sbjct: 64 GVTADW-----HTPLFNACVSGSWDCVNLLLQHGASVQPESDL--------------ASP 104 Query: 167 LSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHS 226 + AA G E V LI +G +I + S T L++ + + LL Sbjct: 105 IHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKK----LLESGADV 160 Query: 227 DHLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHVQW 268 + + + +P + + LM Q Sbjct: 161 NQGKGQD--------SPLHAVARTASEELACLLMDFGADTQA 194 Score = 84.0 bits (206), Expect = 2e-16, Method: Composition-based stats. Identities = 44/193 (22%), Positives = 75/193 (38%), Gaps = 32/193 (16%) Query: 80 ETALHVAALYDNLEAATLLMEAAPELAKEPALCEPFVGQTALHIAVMNQNLNLVRALLAR 139 + +H AA++ + + L+ + A + LH A + +L+ V+ LL Sbjct: 4 WSPMHEAAIHGHQLSLRNLISQGWAVNIITADH-----VSPLHEACLGGHLSCVKILLKH 58 Query: 140 GASVS-ARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNT 198 GA V+ A PL A GS + V LL++HGA ++ + L + Sbjct: 59 GAQVNGVTADWH--------------TPLFNACVSGSWDCVNLLLQHGASVQPESDLA-S 103 Query: 199 VLHILILQPNKTFACQMYNLLLSYDEHSDHLQSLELVPNHQGLTPFKLAGVEGNTVMFQH 258 +H + + + N L++Y + DH S H G TP LA + Sbjct: 104 PIHEAARRGH----VECVNSLIAYGGNIDHKIS------HLG-TPLYLACENQQRACVKK 152 Query: 259 LMQKRKHVQWTCG 271 L++ V G Sbjct: 153 LLESGADVNQGKG 165 >5OEO-C nrPDB Length = 73 Score = 95.2 bits (235), Expect = 9e-20, Method: Composition-based stats. Identities = 55/73 (75%), Positives = 61/73 (83%), Gaps = 1/73 (1%) Query: 654 SDKEDGQEQLSEKRPSTVESGMLSRASVAFQTPSLSRTTSQSSNSHRGWEILRRNTLGHL 713 +DKED QE SEK+PS ESG L+RAS+A T SLSRT SQSS SHRGWEILR+NTLGHL Sbjct: 2 ADKEDDQEHPSEKQPSGAESGTLARASLALPTSSLSRTASQSS-SHRGWEILRQNTLGHL 60 Query: 714 NLGLDLGEGDGEE 726 NLGL+L EGDGEE Sbjct: 61 NLGLNLSEGDGEE 73 >6CUD-A nrPDB Length = 806 Score = 94.0 bits (232), Expect = 2e-19, Method: Composition-based stats. Identities = 96/679 (14%), Positives = 199/679 (29%), Gaps = 154/679 (22%) Query: 46 DSPLLQAAKENDLRLLKILLL-NQSCDFQQRGAVGETALHVAALYDNLE----------- 93 + L AA+ ++ +++ +L +++ + +G+ AL +A ++LE Sbjct: 28 EERFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENL 87 Query: 94 -----------------AATLLMEAAP--------------ELAKEPALCEPFVGQ---- 118 ++ EL + G Sbjct: 88 ARIGDALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYDEDGTRFSP 147 Query: 119 --TALHIAVMNQNLNLVRALLARGASVSARA-----TGAAFRRSPHNLI---------YY 162 T + +A Q +V LL +GA + G + H+ Y Sbjct: 148 DITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCGDCMEKQRHDSFSHSRSRINAYK 207 Query: 163 G-EHPLSFAACVGSEEIVRLLIEHG-ADIRAQDSLGNTVLHILILQPNKTFACQMYNLL- 219 G P + + L + + A + + L +Q K F + +L Sbjct: 208 GLASPAYLSLSSEDPVLTALELSNELAKLANIEKEFKNDYRKLSMQC-KDFVVGVLDLCR 266 Query: 220 ------LSYDEHSDHLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPL 273 + + + LE+ + L+ KLA + + + H L Sbjct: 267 DSEEVEAILNGDLESAEPLEVHRHKASLSRVKLAI---KYEVKKFV----AHPNCQQQLL 319 Query: 274 TSTLYDLTEIDSWGEELSFL-ELVVSSKKREARQILEQTPVKELVSFKW----KKYGR-- 326 T W E LS L E ++ K + P L W + G+ Sbjct: 320 TI----------WYENLSGLREQTIAIKCLVVLVVALGLPF--LAIGYWIAPCSRLGKIL 367 Query: 327 PYFCVLASLYILYMICFTTCCIYRPLKLRDDNRTDPRDITILQQKLLQEAYVTHQDNIRL 386 + + I F ++ + T P K + T Sbjct: 368 RSPFMKFVAHAASFIIFLGLLVFNASDRFEGITTLPNITVTDYPKQIFRVKTTQFTWT-- 425 Query: 387 VGELVTVTGAVIILLLEIPDIFRVGASRYFGQ----------TILGGPF--HVIIITYAS 434 E++ + + ++ E +++ G Y Q +I F + A+ Sbjct: 426 --EMLIMVWVLGMMWSECKELWLEGPREYILQLWNVLDFGMLSIFIAAFTARFLAFLQAT 483 Query: 435 -----------------LVLLTMVMRLT-NMNGEVV---------PLSFALVLGWCSVMY 467 + L + T + + + A+VL + + Y Sbjct: 484 KAQQYVDSYVQESDLSEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAY 543 Query: 468 FARGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFHITFQTEDPNNLGEFSDYP 527 + GP I + + + D+ +F L +V F I + + + Sbjct: 544 ILPANESFGPLQISLGRTV-KDIFKFMVLFIMVFFAFMIGMFILYSY---YLGAKVNAAF 599 Query: 528 TALFSTFELFLTIIDGP-----ANYSVDLPFM---YCITYAAFAIIATLLMLNLFIAMMG 579 T + +F+ I G D F+ + Y + + +++LN+ IAM+ Sbjct: 600 TTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMIN 659 Query: 580 DTHWRVAQERDELWRAQVV 598 ++ + + D W+ Sbjct: 660 SSYQEIEDDSDVEWKFARS 678 >4OT9-A nrPDB Length = 359 Score = 93.6 bits (231), Expect = 3e-19, Method: Composition-based stats. Identities = 39/179 (21%), Positives = 65/179 (36%), Gaps = 25/179 (13%) Query: 46 DSPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVA--ALYDNLEAATLLMEAAP 103 +PL A ++ LL D G++A+H+A A E L+++ Sbjct: 122 QTPLHLAVITGQTSVVSFLLRV-GADPALLDRHGDSAMHLALRAGAGAPELLRALLQSGA 180 Query: 104 ELAKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATG-------------- 149 + F G +H+AV ++ + L+ GA V A Sbjct: 181 PAVPQLLHMPDFEGLYPVHLAVRARSPECLDLLVDSGAEVEATERQGGRTALHLATEMEE 240 Query: 150 --------AAFRRSPHNLIYYGEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVL 200 R + + + G PL AA +G + RLL++ GADI A++ L Sbjct: 241 LGLVTHLVTKLRANVNARTFAGNTPLHLAAGLGYPTLTRLLLKAGADIHAENEEPLCPL 299 Score = 89.8 bits (221), Expect = 4e-18, Method: Composition-based stats. Identities = 55/264 (20%), Positives = 97/264 (36%), Gaps = 35/264 (13%) Query: 38 MLQQERIRDSPLLQAAKENDLRLLKILL-----LNQSCDFQQRGAVGETALHVAALYDNL 92 + Q+ D+PL A +++ ++ + +T LH+A + Sbjct: 75 LTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAVITGQT 134 Query: 93 EAATLLMEAAPELAKEPALCEPFVGQTALHIAVMNQNL--NLVRALLARGASVSARATGA 150 + L+ + PAL + G +A+H+A+ L+RALL GA Sbjct: 135 SVVSFLLRVGAD----PALLDRH-GDSAMHLALRAGAGAPELLRALLQSGA--------P 181 Query: 151 AFRRSPHNLIYYGEHPLSFAACVGSEEIVRLLIEHGADIRAQDSL-GNTVLHILILQPNK 209 A + H + G +P+ A S E + LL++ GA++ A + G T LH+ Sbjct: 182 AVPQLLHMPDFEGLYPVHLAVRARSPECLDLLVDSGAEVEATERQGGRTALHLATEMEEL 241 Query: 210 TFACQMYNLLLSYDEHSDHLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHVQWT 269 + L + + G TP LA G + + L++ + Sbjct: 242 GLVTHLVTKL---RANVNA-------RTFAGNTPLHLAAGLGYPTLTRLLLKAGADIHAE 291 Query: 270 CG----PLTSTLYDLTEIDSWGEE 289 PL S ++ DS G E Sbjct: 292 NEEPLCPLPSPPTSDSDSDSEGPE 315 Score = 77.8 bits (190), Expect = 1e-14, Method: Composition-based stats. Identities = 42/206 (20%), Positives = 77/206 (37%), Gaps = 16/206 (7%) Query: 111 LCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFA 170 + G T LH+A+++ +++ ++ A+ G + + + PL A Sbjct: 76 TAQDENGDTPLHLAIIHGQTSVIEQIVY--VIHHAQDLGVVNLTNHLH-----QTPLHLA 128 Query: 171 ACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHSDHLQ 230 G +V L+ GAD D G++ +H+ + A ++ LL + Sbjct: 129 VITGQTSVVSFLLRVGADPALLDRHGDSAMHLALRAG--AGAPELLRALLQSGAPAVP-- 184 Query: 231 SLELVPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLTSTLYDLTEIDSWGEEL 290 L +P+ +GL P LA + L+ V+ T T L + EEL Sbjct: 185 QLLHMPDFEGLYPVHLAVRARSPECLDLLVDSGAEVEATERQGGRTALHLA---TEMEEL 241 Query: 291 SFLELVVSS--KKREARQILEQTPVK 314 + +V+ AR TP+ Sbjct: 242 GLVTHLVTKLRANVNARTFAGNTPLH 267 Score = 50.1 bits (118), Expect = 3e-06, Method: Composition-based stats. Identities = 24/125 (19%), Positives = 40/125 (32%), Gaps = 28/125 (22%) Query: 41 QERIRDSPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLME 100 + + + L A + +L L+ L+ + R G T LH+AA LL++ Sbjct: 224 ERQGGRTALHLATEMEELGLVTHLVTKLRANVNARTFAGNTPLHLAAGLGYPTLTRLLLK 283 Query: 101 AAPELAKEPALC------------------------EPFVGQTALHIAVMNQNLNLVRAL 136 A ++ E F G T L + + V+ L Sbjct: 284 AGADIHAENEEPLCPLPSPPTSDSDSDSEGPEKDTRSSFRGHTPLDLTCSTK----VKTL 339 Query: 137 LARGA 141 L A Sbjct: 340 LLNAA 344 >1BD8-A nrPDB Length = 156 Score = 90.5 bits (223), Expect = 2e-18, Method: Composition-based stats. Identities = 31/165 (18%), Positives = 61/165 (36%), Gaps = 20/165 (12%) Query: 52 AAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELAKEPAL 111 AA D++ ++ LL + G+TAL V ++ + A L++ Sbjct: 9 AAARGDVQEVRRLLHRELVHPDALNRFGKTALQV-MMFGSTAIALELLKQGASPN----- 62 Query: 112 CEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAA 171 + G + +H A L+ ++ L+ GA V+ G P+ A Sbjct: 63 VQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGT-------------GALPIHLAV 109 Query: 172 CVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMY 216 G +V L +D+ +D+ G T L + + + + + Sbjct: 110 QEGHTAVVSFL-AAESDLHRRDARGLTPLELALQRGAQDLVDILQ 153 Score = 64.7 bits (156), Expect = 1e-10, Method: Composition-based stats. Identities = 26/121 (21%), Positives = 43/121 (35%), Gaps = 19/121 (15%) Query: 65 LLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELAKEPALCEPFVGQTALHIA 124 LL Q + G + +H AA L+ +L+E ++ G +H+A Sbjct: 54 LLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGT-----GALPIHLA 108 Query: 125 VMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVRLLIE 184 V + +V L A H G PL A G++++V +L Sbjct: 109 VQEGHTAVVSFLAA--------------ESDLHRRDARGLTPLELALQRGAQDLVDILQG 154 Query: 185 H 185 H Sbjct: 155 H 155 Score = 64.0 bits (154), Expect = 2e-10, Method: Composition-based stats. Identities = 21/90 (23%), Positives = 33/90 (36%), Gaps = 7/90 (7%) Query: 47 SPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELA 106 SP+ AA+ L LK+L+ D G +H+A + + L A Sbjct: 70 SPVHDAARTGFLDTLKVLVE-HGADVNVPDGTGALPIHLAVQEGHTAVVSFL------AA 122 Query: 107 KEPALCEPFVGQTALHIAVMNQNLNLVRAL 136 + G T L +A+ +LV L Sbjct: 123 ESDLHRRDARGLTPLELALQRGAQDLVDIL 152 >1WG0-A nrPDB Length = 243 Score = 89.8 bits (221), Expect = 4e-18, Method: Composition-based stats. Identities = 44/205 (21%), Positives = 73/205 (35%), Gaps = 23/205 (11%) Query: 48 PLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELAK 107 PL QA EN+ ++ LL ++ Q+ G LH + + E + L+ + Sbjct: 5 PLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNL 64 Query: 108 EPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPL 167 + + G T HIA NL +V++L R + + + G L Sbjct: 65 DDYPDDS--GWTPFHIACSVGNLEVVKSLYDR-----------PLKPDLNKITNQGVTCL 111 Query: 168 SFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHSD 227 A E+ + LIE+GA +R +D LH + + Sbjct: 112 HLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELL-------CGLGK 164 Query: 228 HLQSLELVPNHQGLTPFKLAGVEGN 252 + + QG TP A EG+ Sbjct: 165 SAVNWQD---KQGWTPLFHALAEGH 186 Score = 80.1 bits (196), Expect = 3e-15, Method: Composition-based stats. Identities = 43/197 (21%), Positives = 74/197 (37%), Gaps = 22/197 (11%) Query: 38 MLQQERIRDSPLLQAAKENDLRLLKILL-LNQSCDFQQ-RGAVGETALHVAALYDNLEAA 95 +LQ+++ PL + + LL ++ + G T H+A NLE Sbjct: 29 LLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNLDDYPDDSGWTPFHIACSVGNLEVV 88 Query: 96 TLLMEAAPELAKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRS 155 L + + + G T LH+AV + + + L+ GASV + Sbjct: 89 KSLYDRPLKPDLNKITNQ---GVTCLHLAVGKKWFEVSQFLIENGASVRIKDK------- 138 Query: 156 PHNLIYYGEHPLSFAACVGSEEIVRLLIEHGAD-IRAQDSLGNTVLHILILQPNKTFACQ 214 + + PL AA VGS +++ LL G + QD G T L + + + A Sbjct: 139 ------FNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVL 192 Query: 215 MYNLLLSYDEHSDHLQS 231 + Y D + + Sbjct: 193 LVE---KYGAEYDLVDN 206 Score = 45.5 bits (106), Expect = 9e-05, Method: Composition-based stats. Identities = 41/178 (23%), Positives = 71/178 (39%), Gaps = 23/178 (12%) Query: 166 PLSFAACVGSE-EIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDE 224 PL A ++ LL + + +D G LH + A ++ + LLS E Sbjct: 5 PLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQ----AHEITSFLLSKME 60 Query: 225 HSDHLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLTSTLYDLTEID 284 + + L+ P+ G TPF +A GN + + L + PL DL +I Sbjct: 61 NVN----LDDYPDDSGWTPFHIACSVGNLEVVKSLYDR---------PLKP---DLNKIT 104 Query: 285 SWGEELSFLELVVSSKKREARQILEQTPVKELVSFKWKKYGRPYFCVLASLYILYMIC 342 + G ++ L L V K E Q L + + K+ + + SL ++ ++C Sbjct: 105 NQG--VTCLHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLC 160 >6CV9-A nrPDB Length = 842 Score = 86.3 bits (212), Expect = 5e-17, Method: Composition-based stats. Identities = 28/168 (16%), Positives = 65/168 (38%), Gaps = 17/168 (10%) Query: 455 SFALVLGWCSVMYFARGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASA-FHITFQ 513 + A+VL + + Y + GP I + + + D+ +F + +V + F F++ Sbjct: 511 AIAVVLSFSRIAYILPANESFGPLQISLGRTV-KDIFKFMVIFIMVFVAFMIGMFNLYSY 569 Query: 514 TEDPNNLGEFSDYPTALFSTFELFLTIIDGP-------ANYSVDL-PFMYCITYAAFAII 565 + ++ T + +F+ I G NY+ + + Y + + Sbjct: 570 YIG----AKQNEAFTTVEESFKTLFWAIFGLSEVKSVVINYNHKFIENIGYVLYGVYNVT 625 Query: 566 ATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVA---TTVMLERKMPR 610 +++LN+ IAM+ + + + D W+ + R +P Sbjct: 626 MVIVLLNMLIAMINSSFQEIEDDADVEWKFARAKLWFSYFEEGRTLPV 673 Score = 57.4 bits (137), Expect = 2e-08, Method: Composition-based stats. Identities = 31/161 (19%), Positives = 58/161 (36%), Gaps = 23/161 (14%) Query: 44 IRDSPLLQAAKENDLRLLKILLLN-QSCDFQQRGAVGETALHVAALYDNLEAATLLMEAA 102 I + L AA+ ++ +++ +L S + +G+ AL +A ++LE LL++ Sbjct: 8 IEEERFLDAAEYGNIPVVRKMLEECHSLNVNCVDYMGQNALQLAVANEHLEITELLLKK- 66 Query: 103 PELAKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGA------------SVSARATGA 150 + + AL +A+ + +V A+L A + Sbjct: 67 ----ENLSRVGD-----ALLLAISKGYVRIVEAILNHPAFAEGKRLATSPSQSELQQDDF 117 Query: 151 AFRRSPHNLIYYGEHPLSFAACVGSEEIVRLLIEHGADIRA 191 + P+ AA EIV L+ GA I Sbjct: 118 YAYDEDGTRFSHDVTPIILAAHCQEYEIVHTLLRKGARIER 158 Score = 53.6 bits (127), Expect = 3e-07, Method: Composition-based stats. Identities = 35/193 (18%), Positives = 57/193 (29%), Gaps = 40/193 (20%) Query: 83 LHVAALYDNLEAATLLMEAAPELAKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGAS 142 AA Y N+ ++E L C ++GQ AL +AV N++L + LL + Sbjct: 13 FLDAAEYGNIPVVRKMLEECHSLN---VNCVDYMGQNALQLAVANEHLEITELLLKKE-- 67 Query: 143 VSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHI 202 + G L A G IV ++ H A Sbjct: 68 -NLSRVGD---------------ALLLAISKGYVRIVEAILNHPA--------------- 96 Query: 203 LILQPNKTFACQMYNLLLSYDEHSDHLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQK 262 K A L D+ + + +TP LA + L++K Sbjct: 97 --FAEGKRLATSPSQSELQQDDFYAYDED--GTRFSHDVTPIILAAHCQEYEIVHTLLRK 152 Query: 263 RKHVQWTCGPLTS 275 ++ Sbjct: 153 GARIERPHDYFCK 165 >1BLX-B nrPDB Length = 166 Score = 83.2 bits (204), Expect = 4e-16, Method: Composition-based stats. Identities = 37/174 (21%), Positives = 67/174 (38%), Gaps = 20/174 (11%) Query: 38 MLQQERIRDSPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATL 97 ML +E L AA D++ ++ LL + G+TAL V ++ + A Sbjct: 1 MLLEEVCVGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQV-MMFGSPAVALE 59 Query: 98 LMEAAPELAKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPH 157 L++ + A G + +H A L+ ++ L+ GA V+A + Sbjct: 60 LLKQGASPNVQDAS-----GTSPVHDAARTGFLDTLKVLVEHGADVNALDST-------- 106 Query: 158 NLIYYGEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTF 211 G P+ A G +V L +D+ +D+ G T L + + + Sbjct: 107 -----GSLPIHLAIREGHSSVVSFLAPE-SDLHHRDASGLTPLELARQRGAQNL 154 Score = 61.3 bits (147), Expect = 2e-09, Method: Composition-based stats. Identities = 25/121 (20%), Positives = 47/121 (38%), Gaps = 19/121 (15%) Query: 65 LLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELAKEPALCEPFVGQTALHIA 124 LL Q + A G + +H AA L+ +L+E ++ + G +H+A Sbjct: 60 LLKQGASPNVQDASGTSPVHDAARTGFLDTLKVLVEHGADVNALDST-----GSLPIHLA 114 Query: 125 VMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVRLLIE 184 + + ++V L A + + R G PL A G++ ++ +L Sbjct: 115 IREGHSSVVSFL-APESDLHHRDAS-------------GLTPLELARQRGAQNLMDILQG 160 Query: 185 H 185 H Sbjct: 161 H 161 Score = 59.3 bits (142), Expect = 5e-09, Method: Composition-based stats. Identities = 20/90 (22%), Positives = 32/90 (35%), Gaps = 7/90 (7%) Query: 47 SPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELA 106 SP+ AA+ L LK+L+ D + G +H+A + + L Sbjct: 76 SPVHDAARTGFLDTLKVLVE-HGADVNALDSTGSLPIHLAIREGHSSVVSFL------AP 128 Query: 107 KEPALCEPFVGQTALHIAVMNQNLNLVRAL 136 + G T L +A NL+ L Sbjct: 129 ESDLHHRDASGLTPLELARQRGAQNLMDIL 158 >3LJN-A nrPDB Length = 364 Score = 77.4 bits (189), Expect = 2e-14, Method: Composition-based stats. Identities = 45/243 (18%), Positives = 84/243 (34%), Gaps = 28/243 (11%) Query: 48 PLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELAK 107 + AA++ ++ L+ + G TALH+A + ++ A L Sbjct: 23 KIHVAARKGQTDEVRRLIET-GVSPTIQNRFGCTALHLACKFGCVDTAKYLASVG----- 76 Query: 108 EPALCEPFVGQTALHIAVMNQNLNLVRALLARGAS---------VSARATGAAFRRSPHN 158 + + GQ +H+AVM +LV AL+ GA ++ H Sbjct: 77 --EVHSLWHGQKPIHLAVMANKTDLVVALVE-GAKERGQMPESLLNECDEREVNEIGSHV 133 Query: 159 LIYYGEHPLSFAACVG--SEEIVRLLIEHGADIRAQDSLGNTVLHILI-LQPNKTFACQM 215 G+ L + +G E++++L++ GA A+D T L + + + M Sbjct: 134 KHCKGQTALHWCVGLGPEYLEMIKILVQLGASPTAKDKADETPLMRAMEFRNREALDLMM 193 Query: 216 YNLLLSYDEHSDHLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLTS 275 + D+ N QG + A + + ++ V T Sbjct: 194 DTVPSKSSLRLDYA-------NKQGNSHLHWAILINWEDVAMRFVEMGIDVNMEDNEHTV 246 Query: 276 TLY 278 LY Sbjct: 247 PLY 249 Score = 60.9 bits (146), Expect = 2e-09, Method: Composition-based stats. Identities = 39/207 (18%), Positives = 70/207 (33%), Gaps = 46/207 (22%) Query: 41 QERIRDSPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLME 100 Q R + L A K + K L G+ +H+A + + + L+E Sbjct: 49 QNRFGCTALHLACKFGCVDTAKYLASVGEVH---SLWHGQKPIHLAVMANKTDLVVALVE 105 Query: 101 AAPE----------------LAKEPALCEPFVGQTALHIAVMNQ--NLNLVRALLARGAS 142 A E + + + + GQTALH V L +++ L+ GAS Sbjct: 106 GAKERGQMPESLLNECDEREVNEIGSHVKHCKGQTALHWCVGLGPEYLEMIKILVQLGAS 165 Query: 143 VSARATGA----------------------AFRRSPHNLIYY---GEHPLSFAACVGSEE 177 +A+ +S L Y G L +A + E+ Sbjct: 166 PTAKDKADETPLMRAMEFRNREALDLMMDTVPSKSSLRLDYANKQGNSHLHWAILINWED 225 Query: 178 IVRLLIEHGADIRAQDSLGNTVLHILI 204 + +E G D+ +D+ L++ + Sbjct: 226 VAMRFVEMGIDVNMEDNEHTVPLYLSV 252 >1G3N-B nrPDB Length = 168 Score = 70.1 bits (170), Expect = 3e-12, Method: Composition-based stats. Identities = 32/138 (23%), Positives = 51/138 (36%), Gaps = 18/138 (13%) Query: 50 LQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELAKEP 109 LQ K + + + LLL + + G +H AA L+ L+E ++ Sbjct: 42 LQVMKLGNPEIARRLLLR-GANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFQADVN--- 97 Query: 110 ALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSF 169 E G LH+A +L +V L+ AS G + G+ Sbjct: 98 --IEDNEGNLPLHLAAKEGHLRVVEFLVKHTAS----NVGHRNHK--------GDTACDL 143 Query: 170 AACVGSEEIVRLLIEHGA 187 A G E+V L+ +GA Sbjct: 144 ARLYGRNEVVSLMQANGA 161 Score = 64.7 bits (156), Expect = 2e-10, Method: Composition-based stats. Identities = 23/93 (24%), Positives = 34/93 (36%), Gaps = 5/93 (5%) Query: 49 LLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELAKE 108 + AA+ L L+ LL Q D G LH+AA +L L++ Sbjct: 74 IHDAARAGFLDTLQTLLEFQ-ADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNVGH 132 Query: 109 PALCEPFVGQTALHIAVMNQNLNLVRALLARGA 141 G TA +A + +V + A GA Sbjct: 133 R----NHKGDTACDLARLYGRNEVVSLMQANGA 161 Score = 64.4 bits (155), Expect = 2e-10, Method: Composition-based stats. Identities = 40/174 (22%), Positives = 66/174 (37%), Gaps = 29/174 (16%) Query: 83 LHVAALYDNLEAATLLMEAAPELAKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGAS 142 L AA +LE T L++ + + G+TAL + + N + R LL RGA+ Sbjct: 9 LASAAARGDLEQLTSLLQNNVNVNAQNGF-----GRTALQV-MKLGNPEIARRLLLRGAN 62 Query: 143 VSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHI 202 + G + AA G + ++ L+E AD+ +D+ GN LH+ Sbjct: 63 PDLKDRT-------------GFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHL 109 Query: 203 LILQPNKTFACQMYNLLLSYDEHSDHLQSLELVPNHQGLTPFKLAGVEGNTVMF 256 + + + H S NH+G T LA + G + Sbjct: 110 AAKEGHLRVVEFLVK----------HTASNVGHRNHKGDTACDLARLYGRNEVV 153 Score = 55.5 bits (132), Expect = 9e-08, Method: Composition-based stats. Identities = 27/133 (20%), Positives = 49/133 (36%), Gaps = 12/133 (9%) Query: 162 YGEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLS 221 +G L +G+ EI R L+ GA+ +D G V+H LL Sbjct: 37 FGRTALQVMK-LGNPEIARRLLLRGANPDLKDRTGFAVIHDAARAG----FLDTLQTLLE 91 Query: 222 YDEHSDHLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLTSTLYDLT 281 + + + +++G P LA EG+ + + L++ T DL Sbjct: 92 FQADVN-------IEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNVGHRNHKGDTACDLA 144 Query: 282 EIDSWGEELSFLE 294 + E +S ++ Sbjct: 145 RLYGRNEVVSLMQ 157 Score = 42.4 bits (98), Expect = 6e-04, Method: Composition-based stats. Identities = 18/56 (32%), Positives = 29/56 (51%) Query: 48 PLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAP 103 PL AAKE LR+++ L+ + + + R G+TA +A LY E +L+ Sbjct: 106 PLHLAAKEGHLRVVEFLVKHTASNVGHRNHKGDTACDLARLYGRNEVVSLMQANGA 161 >5DND-A nrPDB Length = 588 Score = 69.0 bits (167), Expect = 7e-12, Method: Composition-based stats. Identities = 36/171 (21%), Positives = 60/171 (35%), Gaps = 18/171 (10%) Query: 50 LQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELAKEP 109 L A +L L+ L+ D + + + G+T LHVAA T+L+ ++ Sbjct: 427 LALAHAGELEALQALMEL-GSDLRLKDSNGQTLLHVAARNGRDGVVTMLLHRGMDVN--- 482 Query: 110 ALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSF 169 G + L +AV ++ +R L GA +S + A L Sbjct: 483 --ARDRDGLSPLLLAVQGRHRECIRLLRKAGACLSPQDLKDAGTELCRLASRADMEGLQ- 539 Query: 170 AACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLL 220 G GAD++ G + L + N+ + NL L Sbjct: 540 --AWGQA---------GADLQQPGYDGRSALCVAEAAGNQEVLALLRNLAL 579 Score = 50.5 bits (119), Expect = 3e-06, Method: Composition-based stats. Identities = 28/146 (19%), Positives = 52/146 (35%), Gaps = 18/146 (12%) Query: 37 NMLQQERIRDSPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAAT 96 ++ ++ + L AA+ ++ +LL D R G + L +A + E Sbjct: 447 DLRLKDSNGQTLLHVAARNGRDGVVTMLLHR-GMDVNARDRDGLSPLLLAVQGRHRECIR 505 Query: 97 LLMEAAPELAKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSP 156 LL +A L+ + T L ++ ++A GA + Sbjct: 506 LLRKAGACLSPQDLKDAG----TELCRLASRADMEGLQAWGQAGADLQ------------ 549 Query: 157 HNLIYYGEHPLSFAACVGSEEIVRLL 182 Y G L A G++E++ LL Sbjct: 550 -QPGYDGRSALCVAEAAGNQEVLALL 574 Score = 48.6 bits (114), Expect = 1e-05, Method: Composition-based stats. Identities = 32/191 (16%), Positives = 63/191 (32%), Gaps = 25/191 (13%) Query: 107 KEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHP 166 +E ++ + + AL +A L ++AL+ G+ + + + G+ Sbjct: 413 EEDSVQDAVMPSLALALA-HAGELEALQALMELGSDLRLKDSN-------------GQTL 458 Query: 167 LSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHS 226 L AA G + +V +L+ G D+ A+D G + L + + ++ LL Sbjct: 459 LHVAARNGRDGVVTMLLHRGMDVNARDRDGLSPLLLAVQGRHRECI----RLLRKAGACL 514 Query: 227 DHLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLTSTLYDLTEIDSW 286 T + Q Q +Q G + + E Sbjct: 515 SPQDL------KDAGTELCRLASRADMEGLQAWGQAGADLQ-QPGYDGRSALCVAEAAGN 567 Query: 287 GEELSFLELVV 297 E L+ L + Sbjct: 568 QEVLALLRNLA 578 >6EMK-G nrPDB Length = 426 Score = 68.2 bits (165), Expect = 1e-11, Method: Composition-based stats. Identities = 38/161 (23%), Positives = 68/161 (42%), Gaps = 16/161 (9%) Query: 49 LLQAAKENDLRLLKILLL-NQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELAK 107 L +A E +L ++K LL N G ++LH A+ + L++ + Sbjct: 9 LREAIIEGNLLIVKRLLRRNPDLLTNIDSENGWSSLHYASYHGRYLICVYLIQLGHD--- 65 Query: 108 EPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPL 167 + L + F G T +H+A+M + + LL + F R ++ G P+ Sbjct: 66 KHELIKTFKGNTCVHLALMKGHEQTLHLLLQQ------------FPRFINHRGENGRAPI 113 Query: 168 SFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPN 208 A + + LLI GAD+ D+ G+T LH+ + + Sbjct: 114 HIACMNDYYQCLSLLIGVGADLWVMDTNGDTPLHVCLEYGS 154 Score = 61.3 bits (147), Expect = 1e-09, Method: Composition-based stats. Identities = 35/186 (18%), Positives = 61/186 (32%), Gaps = 25/186 (13%) Query: 47 SPLLQAAKENDLRLLKILLL-NQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPEL 105 S L A+ + L+ + G T +H+A + + + LL++ P Sbjct: 42 SSLHYASYHGRYLICVYLIQLGHDKHELIKTFKGNTCVHLALMKGHEQTLHLLLQQFPRF 101 Query: 106 AKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEH 165 G+ +HIA MN + L+ GA + T G+ Sbjct: 102 INHRGE----NGRAPIHIACMNDYYQCLSLLIGVGADLWVMDTN-------------GDT 144 Query: 166 PLSFAACVGSEEIVRLLIEHGA---DIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSY 222 PL GS +++L+ G D +D GN I +Y+ +L Sbjct: 145 PLHVCLEYGSISCMKMLLNEGEVSLDDNVRDK-GN---WKPIDVAQTFEVGNIYSKVLKE 200 Query: 223 DEHSDH 228 + Sbjct: 201 VKKKGP 206 Score = 58.2 bits (139), Expect = 1e-08, Method: Composition-based stats. Identities = 32/183 (17%), Positives = 60/183 (32%), Gaps = 26/183 (14%) Query: 83 LHVAALYDNLEAATLLMEAAPELAKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGAS 142 L A + NL L+ P+L + G ++LH A + + L+ G Sbjct: 9 LREAIIEGNLLIVKRLLRRNPDL---LTNIDSENGWSSLHYASYHGRYLICVYLIQLGHD 65 Query: 143 VSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVRLLIEH-GADIRAQDSLGNTVLH 201 + + G + A G E+ + LL++ I + G +H Sbjct: 66 -----------KHELIKTFKGNTCVHLALMKGHEQTLHLLLQQFPRFINHRGENGRAPIH 114 Query: 202 ILILQPNKTFACQMYNLLLSYDEHSDHLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQ 261 I + Q +LL+ V + G TP + G+ + L+ Sbjct: 115 IACMN----DYYQCLSLLIGVGADL-------WVMDTNGDTPLHVCLEYGSISCMKMLLN 163 Query: 262 KRK 264 + + Sbjct: 164 EGE 166 Score = 37.8 bits (86), Expect = 0.019, Method: Composition-based stats. Identities = 14/60 (23%), Positives = 22/60 (36%), Gaps = 1/60 (1%) Query: 43 RIRDSPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAA 102 +P+ A ND LL+ D G+T LHV Y ++ +L+ Sbjct: 107 ENGRAPIHIAC-MNDYYQCLSLLIGVGADLWVMDTNGDTPLHVCLEYGSISCMKMLLNEG 165 Score = 31.6 bits (70), Expect = 1.2, Method: Composition-based stats. Identities = 27/130 (20%), Positives = 52/130 (40%), Gaps = 13/130 (10%) Query: 167 LSFAACVGSEEIVRLLIEHGADI--RAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDE 224 L A G+ IV+ L+ D+ G + LH + + +Y + L +D+ Sbjct: 9 LREAIIEGNLLIVKRLLRRNPDLLTNIDSENGWSSLHYA--SYHGRYLICVYLIQLGHDK 66 Query: 225 HSDHLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQK-RKHVQWTCGPLTSTLYDLTEI 283 H EL+ +G T LA ++G+ L+Q+ + + G + + Sbjct: 67 H-------ELIKTFKGNTCVHLALMKGHEQTLHLLLQQFPRFIN-HRGENGRAPIHIACM 118 Query: 284 DSWGEELSFL 293 + + + LS L Sbjct: 119 NDYYQCLSLL 128 >2KXP-C nrPDB Length = 118 Score = 67.8 bits (164), Expect = 2e-11, Method: Composition-based stats. Identities = 24/97 (24%), Positives = 38/97 (39%), Gaps = 6/97 (6%) Query: 46 DSPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPEL 105 D + A K DL +K + + D + G LH AA LE L+ ++ Sbjct: 3 DKEFMWALKNGDLDEVKDYVA-KGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADI 61 Query: 106 AKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGAS 142 T L AV +++ V+ LL++GA Sbjct: 62 NAPDKHH-----ITPLLSAVYEGHVSCVKLLLSKGAD 93 Score = 66.7 bits (161), Expect = 3e-11, Method: Composition-based stats. Identities = 25/120 (20%), Positives = 40/120 (33%), Gaps = 18/120 (15%) Query: 83 LHVAALYDNLEAATLLMEAAPELAKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGAS 142 A +L+ + ++ + G+ LH A L ++ LL +GA Sbjct: 6 FMWALKNGDLDEVKDYVAKGEDVNRT-----LEGGRKPLHYAADCGQLEILEFLLLKGAD 60 Query: 143 VSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHI 202 ++A PL A G V+LL+ GAD + G T L Sbjct: 61 INAPDKHHI-------------TPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTALEA 107 Score = 60.9 bits (146), Expect = 2e-09, Method: Composition-based stats. Identities = 34/141 (24%), Positives = 54/141 (38%), Gaps = 28/141 (19%) Query: 121 LHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVR 180 A+ N +L+ V+ +A+G V+ + G PL +AA G EI+ Sbjct: 6 FMWALKNGDLDEVKDYVAKGEDVN-------------RTLEGGRKPLHYAADCGQLEILE 52 Query: 181 LLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHSDHLQSLELVPNHQG 240 L+ GADI A D T L + + + + LLLS + V G Sbjct: 53 FLLLKGADINAPDKHHITPLLSAVYEGHVSCV----KLLLSKGAD-------KTVKGPDG 101 Query: 241 LTPFKLAGVEGNTVMFQHLMQ 261 LT + + + L+Q Sbjct: 102 LTALEATDNQA----IKALLQ 118 Score = 48.2 bits (113), Expect = 1e-05, Method: Composition-based stats. Identities = 22/115 (19%), Positives = 38/115 (33%), Gaps = 12/115 (10%) Query: 168 SFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHSD 227 +A G + V+ + G D+ G LH ++ LL + Sbjct: 7 MWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQ----LEILEFLLLKGADIN 62 Query: 228 HLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLTSTLYDLTE 282 P+ +TP A EG+ + L+ K + GP T + T+ Sbjct: 63 A-------PDKHHITPLLSAVYEGHVSCVKLLLSKGAD-KTVKGPDGLTALEATD 109 Score = 28.9 bits (63), Expect = 7.9, Method: Composition-based stats. Identities = 14/37 (37%), Positives = 19/37 (51%), Gaps = 1/37 (2%) Query: 47 SPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETAL 83 +PLL A E + LLL++ D +G G TAL Sbjct: 70 TPLLSAVYEGHVS-CVKLLLSKGADKTVKGPDGLTAL 105 >3T9K-A nrPDB Length = 390 Score = 67.0 bits (162), Expect = 3e-11, Method: Composition-based stats. Identities = 25/117 (21%), Positives = 41/117 (35%), Gaps = 16/117 (13%) Query: 99 MEAAPELAKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHN 158 + ++ + T L A +L LL GA+V+ + Sbjct: 220 LAHGADVNWVNGGQDNA---TPLIQATAANSLLACEFLLQNGANVNQADSA--------- 267 Query: 159 LIYYGEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQM 215 G PL A +G + L ++ GAD+ A+DS G L I + N + Sbjct: 268 ----GRGPLHHATILGHTGLACLFLKRGADLGARDSEGRDPLTIAMETANADIVTLL 320 Score = 65.1 bits (157), Expect = 1e-10, Method: Composition-based stats. Identities = 30/143 (20%), Positives = 45/143 (31%), Gaps = 23/143 (16%) Query: 137 LARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLG 196 LA GA V+ G PL A S L+++GA++ DS G Sbjct: 220 LAHGADVNWVNGGQD-----------NATPLIQATAANSLLACEFLLQNGANVNQADSAG 268 Query: 197 NTVLHILILQPNKTFACQMYNLLLSYDEHSDHLQSLELVPNHQGLTPFKLAGVEGNTVMF 256 LH + + AC L L + +G P +A N + Sbjct: 269 RGPLHHATILGHTGLAC----LFLKRGADLGA-------RDSEGRDPLTIAMETANADIV 317 Query: 257 QHL-MQKRKHVQWTCGPLTSTLY 278 L + K + + G Y Sbjct: 318 TLLRLAKMREAEAAQGQAGDETY 340 Score = 60.1 bits (144), Expect = 3e-09, Method: Composition-based stats. Identities = 26/102 (25%), Positives = 42/102 (41%), Gaps = 6/102 (5%) Query: 35 RVNMLQQERIRDSPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEA 94 VN + + +PL+QA N L + LL N + Q + G LH A + + Sbjct: 225 DVNWVNGGQDNATPLIQATAANSLLACEFLLQN-GANVNQADSAGRGPLHHATILGHTGL 283 Query: 95 ATLLMEAAPELAKEPALCEPFVGQTALHIAVMNQNLNLVRAL 136 A L ++ +L G+ L IA+ N ++V L Sbjct: 284 ACLFLKRGADL-----GARDSEGRDPLTIAMETANADIVTLL 320 >5D68-A nrPDB Length = 486 Score = 65.9 bits (159), Expect = 6e-11, Method: Composition-based stats. Identities = 34/165 (20%), Positives = 57/165 (34%), Gaps = 24/165 (14%) Query: 25 GEQDWEQYRDRVNMLQQER-IRDSPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETAL 83 ++ W++ V ++ + + D PL ++A E D LL LL + Q + + Sbjct: 17 KQEKWQRSMSSVTEDKERQWVDDFPLHRSACEGDSELLSRLLS-ERFSVNQLDSDHWAPI 75 Query: 84 HVAALYDNLEAATLLMEAAPELAKEPALCEPFVGQ--TALHIAVMNQNLNLVRALLARGA 141 H A Y +EA +L+E GQ + LH A + +V+ LL Sbjct: 76 HYACWYGKVEATRILLEKG------KCNPNLLNGQLSSPLHFAAGGGHAEIVQILLNH-- 127 Query: 142 SVSARATGAAFRRSPHNLIYYGEHPLSFAACVGS--EEIVRLLIE 184 H G PL+ E L++ Sbjct: 128 ----------PETDRHITDQQGRSPLNICEENKQNNWEEAAKLLK 162 Score = 60.9 bits (146), Expect = 2e-09, Method: Composition-based stats. Identities = 29/129 (22%), Positives = 46/129 (35%), Gaps = 18/129 (13%) Query: 82 ALHVAALYDNLEAATLLMEAAPELAKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGA 141 LH +A + E + L+ + + + +H A + R LL +G Sbjct: 41 PLHRSACEGDSELLSRLLSERFSVNQLDSDHWA-----PIHYACWYGKVEATRILLEKGK 95 Query: 142 SVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVRLLIEHG-ADIRAQDSLGNTVL 200 +P+ L PL FAA G EIV++L+ H D D G + L Sbjct: 96 C------------NPNLLNGQLSSPLHFAAGGGHAEIVQILLNHPETDRHITDQQGRSPL 143 Query: 201 HILILQPNK 209 +I Sbjct: 144 NICEENKQN 152 Score = 43.6 bits (101), Expect = 4e-04, Method: Composition-based stats. Identities = 24/143 (16%), Positives = 49/143 (34%), Gaps = 13/143 (9%) Query: 166 PLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEH 225 PL +AC G E++ L+ + DS +H + +L Sbjct: 41 PLHRSACEGDSELLSRLLSERFSVNQLDSDHWAPIHYAC-----WYGKVEATRILLEKGK 95 Query: 226 SDHLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQK---RKHVQWTCGPLTSTLYDLTE 282 + + N Q +P A G+ + Q L+ +H+ G + + + Sbjct: 96 CNPN-----LLNGQLSSPLHFAAGGGHAEIVQILLNHPETDRHITDQQGRSPLNICEENK 150 Query: 283 IDSWGEELSFLELVVSSKKREAR 305 ++W E L+ ++ + R Sbjct: 151 QNNWEEAAKLLKEAINKPYEKVR 173 >3UI2-A nrPDB Length = 244 Score = 65.9 bits (159), Expect = 6e-11, Method: Composition-based stats. Identities = 29/103 (28%), Positives = 42/103 (40%), Gaps = 6/103 (5%) Query: 45 RDSPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPE 104 ++P AA++ D + L LL + D G TAL A + + LL EA + Sbjct: 45 YETPWWTAARKADEQALSQLL--EDRDVDAVDENGRTALLFVAGLGSDKCVRLLAEAGAD 102 Query: 105 LAKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARA 147 L G TALH+A +V AL+ GA + Sbjct: 103 LDHRDMR----GGLTALHMAAGYVRPEVVEALVELGADIEVED 141 Score = 62.8 bits (151), Expect = 5e-10, Method: Composition-based stats. Identities = 33/124 (26%), Positives = 45/124 (36%), Gaps = 18/124 (14%) Query: 80 ETALHVAALYDNLEAATLLMEAAPELAKEPALCEPFVGQTALHIAVMNQNLNLVRALLAR 139 ET AA + +A + L+E G+TAL + VR L Sbjct: 46 ETPWWTAARKADEQALSQLLE------DRDVDAVDENGRTALLFVAGLGSDKCVRLLAEA 99 Query: 140 GASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTV 199 GA + R + G L AA E+V L+E GADI +D G T Sbjct: 100 GADLDHRD------------MRGGLTALHMAAGYVRPEVVEALVELGADIEVEDERGLTA 147 Query: 200 LHIL 203 L + Sbjct: 148 LELA 151 Score = 53.2 bits (126), Expect = 4e-07, Method: Composition-based stats. Identities = 27/102 (26%), Positives = 37/102 (36%), Gaps = 7/102 (6%) Query: 26 EQDWEQYRDRVNMLQQERIRDSPLLQAAKENDLRLLKILLLNQSCDFQQRGAVG-ETALH 84 EQ Q + ++ + + LL A LL D R G TALH Sbjct: 58 EQALSQLLEDRDVDAVDENGRTALLFVAGLG-SDKCVRLLAEAGADLDHRDMRGGLTALH 116 Query: 85 VAALYDNLEAATLLMEAAPELAKEPALCEPFVGQTALHIAVM 126 +AA Y E L+E ++ E G TAL +A Sbjct: 117 MAAGYVRPEVVEALVELGADI-----EVEDERGLTALELARE 153 Score = 40.5 bits (93), Expect = 0.003, Method: Composition-based stats. Identities = 22/104 (21%), Positives = 35/104 (33%), Gaps = 11/104 (10%) Query: 164 EHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYD 223 E P AA E+ + L+E D+ A D G T L + + LL Sbjct: 46 ETPWWTAARKADEQALSQLLEDR-DVDAVDENGRTALLFVAGLGSDKCV----RLLAEAG 100 Query: 224 EHSDHLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHVQ 267 DH GLT +A + + L++ ++ Sbjct: 101 ADLDHRDM------RGGLTALHMAAGYVRPEVVEALVELGADIE 138 >3EHQ-A nrPDB Length = 222 Score = 65.5 bits (158), Expect = 8e-11, Method: Composition-based stats. Identities = 33/108 (30%), Positives = 50/108 (46%), Gaps = 7/108 (6%) Query: 40 QQERIRDSPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLM 99 +Q D+PL +AAK +L L+ L N+ G TAL+ A + + +L Sbjct: 68 EQAESIDNPLHEAAKRGNLSWLRECLDNR-VGVNGLDKAGSTALYWACHGGHKDIVEMLF 126 Query: 100 -EAAPELAKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSAR 146 + EL ++ L G TALH A ++V+ LLA+GA R Sbjct: 127 TQPNIELNQQNKL-----GDTALHAAAWKGYADIVQLLLAKGARTDLR 169 Score = 61.3 bits (147), Expect = 2e-09, Method: Composition-based stats. Identities = 24/133 (18%), Positives = 42/133 (31%), Gaps = 17/133 (12%) Query: 82 ALHVAALYDNLEAATLLMEAAPELAKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGA 141 LH AA NL ++ + G TAL+ A + ++V L + Sbjct: 76 PLHEAAKRGNLSWLRECLDNRVGVNGLDKA-----GSTALYWACHGGHKDIVEMLFTQ-- 128 Query: 142 SVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLH 201 + G+ L AA G +IV+LL+ GA ++ Sbjct: 129 ----------PNIELNQQNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNIEKKLAFD 178 Query: 202 ILILQPNKTFACQ 214 + + + Sbjct: 179 MATNAACASLLKK 191 Score = 48.2 bits (113), Expect = 1e-05, Method: Composition-based stats. Identities = 20/102 (19%), Positives = 35/102 (34%), Gaps = 10/102 (9%) Query: 166 PLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEH 225 PL AA G+ +R +++ + D G+T L+ +K ++ Sbjct: 76 PLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLF--------- 126 Query: 226 SDHLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHVQ 267 + L N G T A +G + Q L+ K Sbjct: 127 TQPNIELNQ-QNKLGDTALHAAAWKGYADIVQLLLAKGARTD 167 >3DEO-A nrPDB Length = 183 Score = 65.1 bits (157), Expect = 9e-11, Method: Composition-based stats. Identities = 29/103 (28%), Positives = 42/103 (40%), Gaps = 6/103 (5%) Query: 45 RDSPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPE 104 ++P AA++ D + L LL + D G TAL A + + LL EA + Sbjct: 44 YETPWWTAARKADEQALSQLL--EDRDVDAVDENGRTALLFVAGLGSDKCVRLLAEAGAD 101 Query: 105 LAKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARA 147 L G TALH+A +V AL+ GA + Sbjct: 102 LDHRDMR----GGLTALHMAAGYVRPEVVEALVELGADIEVED 140 Score = 62.4 bits (150), Expect = 7e-10, Method: Composition-based stats. Identities = 33/124 (26%), Positives = 45/124 (36%), Gaps = 18/124 (14%) Query: 80 ETALHVAALYDNLEAATLLMEAAPELAKEPALCEPFVGQTALHIAVMNQNLNLVRALLAR 139 ET AA + +A + L+E G+TAL + VR L Sbjct: 45 ETPWWTAARKADEQALSQLLE------DRDVDAVDENGRTALLFVAGLGSDKCVRLLAEA 98 Query: 140 GASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTV 199 GA + R + G L AA E+V L+E GADI +D G T Sbjct: 99 GADLDHRD------------MRGGLTALHMAAGYVRPEVVEALVELGADIEVEDERGLTA 146 Query: 200 LHIL 203 L + Sbjct: 147 LELA 150 Score = 52.8 bits (125), Expect = 5e-07, Method: Composition-based stats. Identities = 27/102 (26%), Positives = 37/102 (36%), Gaps = 7/102 (6%) Query: 26 EQDWEQYRDRVNMLQQERIRDSPLLQAAKENDLRLLKILLLNQSCDFQQRGAVG-ETALH 84 EQ Q + ++ + + LL A LL D R G TALH Sbjct: 57 EQALSQLLEDRDVDAVDENGRTALLFVAGLG-SDKCVRLLAEAGADLDHRDMRGGLTALH 115 Query: 85 VAALYDNLEAATLLMEAAPELAKEPALCEPFVGQTALHIAVM 126 +AA Y E L+E ++ E G TAL +A Sbjct: 116 MAAGYVRPEVVEALVELGADI-----EVEDERGLTALELARE 152 Score = 40.1 bits (92), Expect = 0.004, Method: Composition-based stats. Identities = 22/104 (21%), Positives = 35/104 (33%), Gaps = 11/104 (10%) Query: 164 EHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYD 223 E P AA E+ + L+E D+ A D G T L + + LL Sbjct: 45 ETPWWTAARKADEQALSQLLEDR-DVDAVDENGRTALLFVAGLGSDKCV----RLLAEAG 99 Query: 224 EHSDHLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHVQ 267 DH GLT +A + + L++ ++ Sbjct: 100 ADLDHRDM------RGGLTALHMAAGYVRPEVVEALVELGADIE 137 >1D9S-A nrPDB Length = 136 Score = 59.7 bits (143), Expect = 5e-09, Method: Composition-based stats. Identities = 29/143 (20%), Positives = 45/143 (31%), Gaps = 19/143 (13%) Query: 46 DSPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPEL 105 D+ L AA + ++ LL D G + V + + + A LL+ E Sbjct: 13 DAGLATAAARGQVETVRQLLEA-GADPNALNRFGRRPIQV-MMMGSAQVAELLLLHGAE- 69 Query: 106 AKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEH 165 P +P +H A L+ + L GA +G Sbjct: 70 ---PNCADPATLTRPVHDAAREGFLDTLVVLHRAGA-------------RLDVCDAWGRL 113 Query: 166 PLSFAACVGSEEIVRLLIEHGAD 188 P+ A G +I R L D Sbjct: 114 PVDLAEEQGHRDIARYLHAATGD 136 Score = 58.2 bits (139), Expect = 1e-08, Method: Composition-based stats. Identities = 26/141 (18%), Positives = 47/141 (33%), Gaps = 18/141 (12%) Query: 72 FQQRGAVGETALHVAALYDNLEAATLLMEAAPELAKEPALCEPFVGQTALHIAVMNQNLN 131 G + L AA +E L+EA + G+ + + +M + Sbjct: 5 IHMLGGSSDAGLATAAARGQVETVRQLLEAGADPNALNRF-----GRRPIQV-MMMGSAQ 58 Query: 132 LVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVRLLIEHGADIRA 191 + LL GA + R P+ AA G + + +L GA + Sbjct: 59 VAELLLLHGAEPNCADPATLTR------------PVHDAAREGFLDTLVVLHRAGARLDV 106 Query: 192 QDSLGNTVLHILILQPNKTFA 212 D+ G + + Q ++ A Sbjct: 107 CDAWGRLPVDLAEEQGHRDIA 127 Score = 53.6 bits (127), Expect = 3e-07, Method: Composition-based stats. Identities = 28/127 (22%), Positives = 43/127 (33%), Gaps = 12/127 (9%) Query: 167 LSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHS 226 L+ AA G E VR L+E GAD A + G + ++++ Q+ LLL + Sbjct: 16 LATAAARGQVETVRQLLEAGADPNALNRFGRRPIQVMMMGS-----AQVAELLLLHGAEP 70 Query: 227 DHLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLTSTLYDLTEIDSW 286 + L P A EG L + + DL E Sbjct: 71 NCADPATLTR------PVHDAAREGFLDTLVVLHRAGARLDVC-DAWGRLPVDLAEEQGH 123 Query: 287 GEELSFL 293 + +L Sbjct: 124 RDIARYL 130 >6BWF-A nrPDB Length = 954 Score = 57.4 bits (137), Expect = 2e-08, Method: Composition-based stats. Identities = 29/157 (18%), Positives = 60/157 (38%), Gaps = 23/157 (14%) Query: 456 FALVLGWCSVMYFARGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFHITFQTE 515 ++ + ++ F Q GP+ +MI KM+ ++ +MA+V+L F Sbjct: 621 LNIIFWYVRLLDFLAVNQQAGPYVMMIGKMV-ANMFYIVVIMALVLLSFGVPRKAILY-- 677 Query: 516 DPNNLGEFSDYPTALFSTFELFLTIIDGPA--------NYSVDLP-------FMYCITYA 560 P+ +S +F + +I G LP ++ A Sbjct: 678 -PHEEPSWSLAKDIVFHPY----WMIFGEVYAYEIDVCANDSTLPTICGPGTWLTPFLQA 732 Query: 561 AFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQV 597 + + ++M+NL IA + + +V + +W+ Q Sbjct: 733 VYLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQR 769 >6DJS-A nrPDB Length = 676 Score = 56.6 bits (135), Expect = 3e-08, Method: Composition-based stats. Identities = 28/159 (17%), Positives = 60/159 (37%), Gaps = 23/159 (14%) Query: 46 DSPLLQAAKENDLRLLKILLL-NQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPE 104 + L AA+ ++ +++ +L +++ + +G+ AL +A ++LE LL++ Sbjct: 45 EERFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKK--- 101 Query: 105 LAKEPALCEPFVGQTALHIAVMNQNLNLVRALLAR-----------GASVSARATGAAFR 153 + A AL +A+ + +V A+L + Sbjct: 102 --ENLARIGD-----ALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYA 154 Query: 154 RSPHNLIYYGE-HPLSFAACVGSEEIVRLLIEHGADIRA 191 + + P+ AA E+V +L+ GA I Sbjct: 155 YDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIER 193 Score = 49.3 bits (116), Expect = 6e-06, Method: Composition-based stats. Identities = 35/193 (18%), Positives = 58/193 (30%), Gaps = 40/193 (20%) Query: 83 LHVAALYDNLEAATLLMEAAPELAKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGAS 142 AA Y N+ ++E + L C ++GQ AL +AV N++L + LL + Sbjct: 48 FLDAAEYGNIPVVRKMLEESKTLN---VNCVDYMGQNALQLAVGNEHLEVTELLLKK--- 101 Query: 143 VSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHI 202 NL G+ L A G IV ++ H Sbjct: 102 --------------ENLARIGD-ALLLAISKGYVRIVEAILNHPG--------------- 131 Query: 203 LILQPNKTFACQMYNLLLSYDEHSDHLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQK 262 +K L D+ + + +TP LA + L+ K Sbjct: 132 --FAASKRLTLSPCEQELQDDDFYAYDED--GTRFSPDITPIILAAHCQKYEVVHMLLMK 187 Query: 263 RKHVQWTCGPLTS 275 ++ Sbjct: 188 GARIERPHDYFCK 200 >4BSZ-B nrPDB Length = 202 Score = 56.3 bits (134), Expect = 4e-08, Method: Composition-based stats. Identities = 33/147 (22%), Positives = 54/147 (36%), Gaps = 23/147 (15%) Query: 49 LLQAAKENDLRLLK----ILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLME---- 100 ++ A+ DL LK L+ + + TALH+AA ++E ++E Sbjct: 18 IILDARAGDLDSLKDIFTTLVSPELLSTCKESESDSTALHMAAANGHIETVRYILETVSR 77 Query: 101 -AAPELAKEPALCEPFVGQTALHIAVMNQNLNLVRALL-ARGASVSARATGAAFRRSPHN 158 + E K G TALH A +N L++V+ L A R Sbjct: 78 ANSAEDLKAFVNEVNKTGNTALHWASLNGKLDVVKLLCDEYEADPFIRNK---------- 127 Query: 159 LIYYGEHPLSFAACVGSEEIVRLLIEH 185 +G + A G EE+ ++ Sbjct: 128 ---FGHDAIFEAENSGKEEVETYFLKK 151 Score = 55.9 bits (133), Expect = 7e-08, Method: Composition-based stats. Identities = 28/155 (18%), Positives = 57/155 (36%), Gaps = 8/155 (5%) Query: 69 SCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELAKEPALCEPFVGQTALHIAVMNQ 128 + + + + A +L++ + E TALH+A N Sbjct: 4 GLHSEPLDQEDQDTIILDARAGDLDSLKDIFTTLVSPELLSTCKESESDSTALHMAAANG 63 Query: 129 NLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVRLLI-EHGA 187 ++ VR +L +VS + + + + G L +A+ G ++V+LL E+ A Sbjct: 64 HIETVRYILE---TVSRANSAEDLKAFVNEVNKTGNTALHWASLNGKLDVVKLLCDEYEA 120 Query: 188 DIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSY 222 D ++ G H I + + ++ L Sbjct: 121 DPFIRNKFG----HDAIFEAENSGKEEVETYFLKK 151 Score = 42.0 bits (97), Expect = 0.001, Method: Composition-based stats. Identities = 23/108 (21%), Positives = 36/108 (33%), Gaps = 20/108 (18%) Query: 165 HPLSFAACVGSEEIVRLLIE-----HGAD-----IRAQDSLGNTVLHILILQPNKTFACQ 214 L AA G E VR ++E + A+ + + GNT LH L Sbjct: 54 TALHMAAANGHIETVRYILETVSRANSAEDLKAFVNEVNKTGNTALHWASLNGKLDVVK- 112 Query: 215 MYNLLLSYDEHSDHLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQK 262 LL + +D + N G A G + + ++K Sbjct: 113 ----LLCDEYEADP-----FIRNKFGHDAIFEAENSGKEEVETYFLKK 151 >5U0K-A nrPDB Length = 141 Score = 53.6 bits (127), Expect = 3e-07, Method: Composition-based stats. Identities = 27/88 (30%), Positives = 39/88 (44%), Gaps = 5/88 (5%) Query: 49 LLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELAKE 108 LL AA D+ L+ + D +Q+ TALHVAA ++E L+EA K Sbjct: 29 LLFAAYSGDVSALRRF-ALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFLIEA----CKV 83 Query: 109 PALCEPFVGQTALHIAVMNQNLNLVRAL 136 + G L AV +L +V+ L Sbjct: 84 NPFAKDRWGNIPLDDAVQFNHLEVVKLL 111 Score = 52.8 bits (125), Expect = 6e-07, Method: Composition-based stats. Identities = 22/100 (22%), Positives = 41/100 (41%), Gaps = 17/100 (17%) Query: 83 LHVAALYDNLEAATLLMEAAPELAKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGAS 142 L AA ++ A +A ++ ++ + +TALH+A ++ +V+ L+ Sbjct: 29 LLFAAYSGDVSALRRFALSAMDMEQK-----DYDSRTALHVAAAEGHIEVVKFLIEA-CK 82 Query: 143 VSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVRLL 182 V+ A +G PL A E+V+LL Sbjct: 83 VNPFAKDR-----------WGNIPLDDAVQFNHLEVVKLL 111 Score = 46.6 bits (109), Expect = 4e-05, Method: Composition-based stats. Identities = 22/88 (25%), Positives = 31/88 (35%), Gaps = 2/88 (2%) Query: 132 LVRALLA-RGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVRLLIEH-GADI 189 +V L A VSA A Y L AA G E+V+ LIE + Sbjct: 26 VVNLLFAAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFLIEACKVNP 85 Query: 190 RAQDSLGNTVLHILILQPNKTFACQMYN 217 A+D GN L + + + + Sbjct: 86 FAKDRWGNIPLDDAVQFNHLEVVKLLQD 113 Score = 45.1 bits (105), Expect = 1e-04, Method: Composition-based stats. Identities = 15/63 (23%), Positives = 29/63 (46%) Query: 36 VNMLQQERIRDSPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAA 95 ++M Q++ + L AA E + ++K L+ + + G L A +++LE Sbjct: 49 MDMEQKDYDSRTALHVAAAEGHIEVVKFLIEACKVNPFAKDRWGNIPLDDAVQFNHLEVV 108 Query: 96 TLL 98 LL Sbjct: 109 KLL 111 >6BPQ-A nrPDB Length = 950 Score = 52.4 bits (124), Expect = 6e-07, Method: Composition-based stats. Identities = 41/236 (17%), Positives = 85/236 (36%), Gaps = 33/236 (13%) Query: 389 ELVTVTGAVIILLLEIPDIFRVGASRYFGQTILGGPFHVIIITYASLVLLTMVMRLTNMN 448 E++ I+L E+ + G+ + + + + + + Sbjct: 643 EIILYVLVFILLCDEVRQWYMNGSKYFSDLWNVMDTLAIFYFIAGIVFR----LHSDESS 698 Query: 449 GEVVPLSFAL--VLGWCSVMYFARGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFAS 506 + F L ++ +++ + LGP IM+Q+M+ D+ F +L AV ++ F Sbjct: 699 WYSGRVIFCLDYIVFTLRLIHIFTVSRNLGPKIIMLQRMMI-DVFFFLFLFAVWMVAFGV 757 Query: 507 A------------------------FHITFQTEDPNNLGEFSDYPTALFSTFELFLTIID 542 A + Q D + G ++ FS E ++ Sbjct: 758 ARQGILRKNEHRWEWIFRSVIYEPYLAMFGQYPDDID-GTTYNFDHCTFSGNESKPLCVE 816 Query: 543 GPANYSVDLP-FMYCITYAAFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQV 597 AN P ++ + + +L++NL +AM G T V + D++W+ Q Sbjct: 817 LDANNQPRFPEWITIPLVCIYMLSTNILLVNLLVAMFGYTVGSVQENNDQVWKFQR 872 >1DCQ-A nrPDB Length = 278 Score = 50.9 bits (120), Expect = 2e-06, Method: Composition-based stats. Identities = 34/166 (20%), Positives = 55/166 (33%), Gaps = 29/166 (17%) Query: 30 EQYRDRVNMLQQERIRDSPLLQAAKENDLRLLKILLLNQSCDFQQRGAV--------GET 81 +Y +R ++ + L + R + LL + + ET Sbjct: 112 AKYMERRYARKKHADTAAKLHSLCEAVKTRDIFGLLQAYADGVDLTEKIPLANGHEPDET 171 Query: 82 ALHVAALY---DNLEAATLLMEAAPELAKEPALCEPFVGQTALHIAVMNQNLNLVRALLA 138 ALH+A +L L++ + L K+ G TALH + N ++ LL Sbjct: 172 ALHLAVRSVDRTSLHIVDFLVQNSGNLDKQTG-----KGSTALHYCCLTDNAECLKLLLR 226 Query: 139 RGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVRLLIE 184 AS+ GE PL A + E LL + Sbjct: 227 GKASIEIANES-------------GETPLDIAKRLKHEHCEELLTQ 259 Score = 43.9 bits (102), Expect = 2e-04, Method: Composition-based stats. Identities = 27/155 (17%), Positives = 50/155 (32%), Gaps = 33/155 (21%) Query: 53 AKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAAT-LLMEAAPELAKEPAL 111 A++ L + R G + A D ++ + + E + Sbjct: 120 ARKKHADTAAKLHSLCEA-VKTRDIFGL----LQAYADGVDLTEKIPLANGHEPDE---- 170 Query: 112 CEPFVGQTALHIAV---MNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLS 168 TALH+AV +L++V L+ ++ + G L Sbjct: 171 -------TALHLAVRSVDRTSLHIVDFLVQNSGNLDKQTGK-------------GSTALH 210 Query: 169 FAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHIL 203 + + E ++LL+ A I + G T L I Sbjct: 211 YCCLTDNAECLKLLLRGKASIEIANESGETPLDIA 245 Score = 40.5 bits (93), Expect = 0.003, Method: Composition-based stats. Identities = 27/136 (19%), Positives = 41/136 (30%), Gaps = 20/136 (14%) Query: 121 LHIAVMN-QNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACV---GSE 176 LH + ++ L A V + E L A S Sbjct: 131 LHSLCEAVKTRDIFGLLQAYADGVDLTEKIPLANGHEPD-----ETALHLAVRSVDRTSL 185 Query: 177 EIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHSDHLQSLELVP 236 IV L+++ ++ Q G+T LH L N + LLL + Sbjct: 186 HIVDFLVQNSGNLDKQTGKGSTALHYCCLTDN----AECLKLLLRGKASI-------EIA 234 Query: 237 NHQGLTPFKLAGVEGN 252 N G TP +A + Sbjct: 235 NESGETPLDIAKRLKH 250 >5UQE-A nrPDB Length = 520 Score = 50.5 bits (119), Expect = 3e-06, Method: Composition-based stats. Identities = 24/91 (26%), Positives = 39/91 (42%), Gaps = 5/91 (5%) Query: 49 LLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELAKE 108 LL AA D+ L+ + D +QR TALHVAA ++E L+E A ++ Sbjct: 421 LLFAAYTGDVSALRRF-ALSAMDMEQRDYDSRTALHVAAAEGHVEVVKFLLE-ACKVNPF 478 Query: 109 PALCEPFVGQTALHIAVMNQNLNLVRALLAR 139 P T + A+ + ++ + L Sbjct: 479 PK---DRWNNTPMDEALHFGHHDVFKILQEY 506 Score = 46.2 bits (108), Expect = 5e-05, Method: Composition-based stats. Identities = 21/110 (19%), Positives = 43/110 (39%), Gaps = 17/110 (15%) Query: 83 LHVAALYDNLEAATLLMEAAPELAKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGAS 142 L AA ++ A +A ++ + + +TALH+A ++ +V+ LL Sbjct: 421 LLFAAYTGDVSALRRFALSAMDMEQR-----DYDSRTALHVAAAEGHVEVVKFLLEA-CK 474 Query: 143 VSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVRLLIEHGADIRAQ 192 V+ F + + P+ A G ++ ++L E+ Q Sbjct: 475 VNP------FPKDR-----WNNTPMDEALHFGHHDVFKILQEYQVQYTPQ 513 Score = 45.1 bits (105), Expect = 1e-04, Method: Composition-based stats. Identities = 19/96 (19%), Positives = 29/96 (30%), Gaps = 1/96 (1%) Query: 135 ALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVRLLIEH-GADIRAQD 193 A VSA A Y L AA G E+V+ L+E + +D Sbjct: 422 LFAAYTGDVSALRRFALSAMDMEQRDYDSRTALHVAAAEGHVEVVKFLLEACKVNPFPKD 481 Query: 194 SLGNTVLHILILQPNKTFACQMYNLLLSYDEHSDHL 229 NT + + + + + Y D Sbjct: 482 RWNNTPMDEALHFGHHDVFKILQEYQVQYTPQGDSD 517 Score = 38.9 bits (89), Expect = 0.009, Method: Composition-based stats. Identities = 13/65 (20%), Positives = 28/65 (43%) Query: 36 VNMLQQERIRDSPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAA 95 ++M Q++ + L AA E + ++K LL + + T + A + + + Sbjct: 441 MDMEQRDYDSRTALHVAAAEGHVEVVKFLLEACKVNPFPKDRWNNTPMDEALHFGHHDVF 500 Query: 96 TLLME 100 +L E Sbjct: 501 KILQE 505 Score = 32.4 bits (72), Expect = 0.67, Method: Composition-based stats. Identities = 19/98 (19%), Positives = 33/98 (33%), Gaps = 12/98 (12%) Query: 167 LSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYD-EH 225 L FAA G +R D+ +D T LH+ + + ++ LL + Sbjct: 421 LLFAAYTGDVSALRRFALSAMDMEQRDYDSRTALHVAAAEGH----VEVVKFLLEACKVN 476 Query: 226 SDHLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQKR 263 TP A G+ +F+ L + + Sbjct: 477 PFPKDRWN-------NTPMDEALHFGHHDVFKILQEYQ 507 >5U0J-A nrPDB Length = 140 Score = 50.5 bits (119), Expect = 3e-06, Method: Composition-based stats. Identities = 24/108 (22%), Positives = 42/108 (38%), Gaps = 5/108 (4%) Query: 49 LLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELAKE 108 LL AA D+ L+ + D +QR TALHVAA ++E L+EA K Sbjct: 28 LLFAAYTGDVSALRRF-ALSAMDMEQRDYDSRTALHVAAAEGHVEVVKFLLEA----CKV 82 Query: 109 PALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSP 156 + T + A+ + ++ + L + + + + Sbjct: 83 NPFPKDRWNNTPMDEALHFGHHDVFKILQEYQVQYTPQGDSDNGKENQ 130 Score = 45.9 bits (107), Expect = 6e-05, Method: Composition-based stats. Identities = 21/110 (19%), Positives = 43/110 (39%), Gaps = 17/110 (15%) Query: 83 LHVAALYDNLEAATLLMEAAPELAKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGAS 142 L AA ++ A +A ++ + + +TALH+A ++ +V+ LL Sbjct: 28 LLFAAYTGDVSALRRFALSAMDMEQR-----DYDSRTALHVAAAEGHVEVVKFLLEA-CK 81 Query: 143 VSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVRLLIEHGADIRAQ 192 V+ F + + P+ A G ++ ++L E+ Q Sbjct: 82 VNP------FPKDR-----WNNTPMDEALHFGHHDVFKILQEYQVQYTPQ 120 Score = 45.9 bits (107), Expect = 7e-05, Method: Composition-based stats. Identities = 22/108 (20%), Positives = 33/108 (30%), Gaps = 1/108 (0%) Query: 135 ALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVRLLIEH-GADIRAQD 193 A VSA A Y L AA G E+V+ L+E + +D Sbjct: 29 LFAAYTGDVSALRRFALSAMDMEQRDYDSRTALHVAAAEGHVEVVKFLLEACKVNPFPKD 88 Query: 194 SLGNTVLHILILQPNKTFACQMYNLLLSYDEHSDHLQSLELVPNHQGL 241 NT + + + + + Y D E H+ L Sbjct: 89 RWNNTPMDEALHFGHHDVFKILQEYQVQYTPQGDSDNGKENQTVHKNL 136 Score = 39.7 bits (91), Expect = 0.005, Method: Composition-based stats. Identities = 15/84 (17%), Positives = 32/84 (38%) Query: 36 VNMLQQERIRDSPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAA 95 ++M Q++ + L AA E + ++K LL + + T + A + + + Sbjct: 48 MDMEQRDYDSRTALHVAAAEGHVEVVKFLLEACKVNPFPKDRWNNTPMDEALHFGHHDVF 107 Query: 96 TLLMEAAPELAKEPALCEPFVGQT 119 +L E + + QT Sbjct: 108 KILQEYQVQYTPQGDSDNGKENQT 131 Score = 33.9 bits (76), Expect = 0.24, Method: Composition-based stats. Identities = 22/127 (17%), Positives = 39/127 (30%), Gaps = 23/127 (18%) Query: 167 LSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYD-EH 225 L FAA G +R D+ +D T LH+ + + ++ LL + Sbjct: 28 LLFAAYTGDVSALRRFALSAMDMEQRDYDSRTALHVAAAEGH----VEVVKFLLEACKVN 83 Query: 226 SDHLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLTSTLYDLTEIDS 285 TP A G+ +F+ L + + P + D+ Sbjct: 84 PFPKDRWN-------NTPMDEALHFGHHDVFKILQEYQV----QYTPQGDS-------DN 125 Query: 286 WGEELSF 292 E + Sbjct: 126 GKENQTV 132 >2A5E-A nrPDB Length = 156 Score = 50.1 bits (118), Expect = 3e-06, Method: Composition-based stats. Identities = 24/130 (18%), Positives = 45/130 (34%), Gaps = 18/130 (13%) Query: 83 LHVAALYDNLEAATLLMEAAPELAKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGAS 142 L AA +E L+EA + G+ + + +M + + LL GA Sbjct: 16 LATAAARGRVEEVRALLEAGALPNAPNS-----YGRRPIQV-MMMGSARVAELLLLHGAE 69 Query: 143 VSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHI 202 + R P+ AA G + + +L GA + +D+ G + + Sbjct: 70 PNCADPATLTR------------PVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDL 117 Query: 203 LILQPNKTFA 212 ++ A Sbjct: 118 AEELGHRDVA 127 Score = 47.0 bits (110), Expect = 3e-05, Method: Composition-based stats. Identities = 27/143 (18%), Positives = 46/143 (32%), Gaps = 12/143 (8%) Query: 167 LSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHS 226 L+ AA G E VR L+E GA A +S G + ++++ ++ LLL + Sbjct: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMMGS-----ARVAELLLLHGAEP 70 Query: 227 DHLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLTSTLYDLTEIDSW 286 + L P A EG L + + DL E Sbjct: 71 NCADPATLTR------PVHDAAREGFLDTLVVLHRAGARLD-VRDAWGRLPVDLAEELGH 123 Query: 287 GEELSFLELVVSSKKREARQILE 309 + +L + ++ Sbjct: 124 RDVARYLRAAAGGTRGSNHARID 146 Score = 35.5 bits (80), Expect = 0.097, Method: Composition-based stats. Identities = 13/52 (25%), Positives = 20/52 (38%), Gaps = 1/52 (1%) Query: 47 SPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLL 98 P+ AA+E L L +L R A G + +A + + A L Sbjct: 80 RPVHDAAREGFLDTLVVL-HRAGARLDVRDAWGRLPVDLAEELGHRDVARYL 130 >5Z1W-A nrPDB Length = 566 Score = 45.5 bits (106), Expect = 9e-05, Method: Composition-based stats. Identities = 23/131 (17%), Positives = 57/131 (43%), Gaps = 6/131 (4%) Query: 458 LVLGWCSVMYFARGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFHITFQTEDP 517 L W + + + + + + + D++ F + +V +A ++ F T+ Sbjct: 383 LFFAWIKIFKYISFNKTMTQLSSTLARCA-KDILGFAIMFFIVFFAYAQLGYLLFGTQ-- 439 Query: 518 NNLGEFSDYPTALFSTFELFLTIIDGPANYSVDLPFMYCITYAAFAIIATLLMLNLFIAM 577 + FS + +F+ F + L D A + + + + + + ++LN+F+A+ Sbjct: 440 --VENFSTFVKCIFTQFRIILGDFDYNAIDNAN-RILGPVYFVTYVFFVFFVLLNMFLAI 496 Query: 578 MGDTHWRVAQE 588 + DT+ V +E Sbjct: 497 INDTYSEVKEE 507 >3LVQ-E nrPDB Length = 497 Score = 45.1 bits (105), Expect = 1e-04, Method: Composition-based stats. Identities = 23/93 (24%), Positives = 38/93 (40%), Gaps = 16/93 (17%) Query: 121 LHIAVMNQN---LNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEE 177 LH+AV N L LV ++ G + A+A G L +AA + Sbjct: 175 LHLAVKVANQASLPLVDFIIQNGGHLDAKAAD-------------GNTALHYAALYNQPD 221 Query: 178 IVRLLIEHGADIRAQDSLGNTVLHILILQPNKT 210 ++LL++ A + + G T L I + +K Sbjct: 222 CLKLLLKGRALVGTVNEAGETALDIARKKHHKE 254 Score = 45.1 bits (105), Expect = 1e-04, Method: Composition-based stats. Identities = 27/99 (27%), Positives = 37/99 (37%), Gaps = 7/99 (7%) Query: 49 LLQAAK-ENDLRL-LKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELA 106 L A K N L L ++ + A G TALH AALY+ + LL++ + Sbjct: 175 LHLAVKVANQASLPLVDFIIQNGGHLDAKAADGNTALHYAALYNQPDCLKLLLKGRALVG 234 Query: 107 KEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSA 145 G+TAL IA + L A A Sbjct: 235 TVNEA-----GETALDIARKKHHKECEELLEQAQAGTFA 268 Score = 40.1 bits (92), Expect = 0.004, Method: Composition-based stats. Identities = 24/106 (22%), Positives = 37/106 (34%), Gaps = 14/106 (13%) Query: 164 EHPLSFA---ACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLL 220 E L A A S +V +I++G + A+ + GNT LH L LL Sbjct: 172 ELVLHLAVKVANQASLPLVDFIIQNGGHLDAKAADGNTALHYAALYNQPDCLK-----LL 226 Query: 221 SYDEHSDHLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHV 266 +L N G T +A + + + L Q + Sbjct: 227 LKGR------ALVGTVNEAGETALDIARKKHHKECEELLEQAQAGT 266 >2B0O-E nrPDB Length = 301 Score = 45.1 bits (105), Expect = 1e-04, Method: Composition-based stats. Identities = 23/93 (24%), Positives = 38/93 (40%), Gaps = 16/93 (17%) Query: 121 LHIAVMNQN---LNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEE 177 LH+AV N L LV ++ G + A+A G L +AA + Sbjct: 194 LHLAVKVANQASLPLVDFIIQNGGHLDAKAAD-------------GNTALHYAALYNQPD 240 Query: 178 IVRLLIEHGADIRAQDSLGNTVLHILILQPNKT 210 ++LL++ A + + G T L I + +K Sbjct: 241 CLKLLLKGRALVGTVNEAGETALDIARKKHHKE 273 Score = 45.1 bits (105), Expect = 1e-04, Method: Composition-based stats. Identities = 27/99 (27%), Positives = 37/99 (37%), Gaps = 7/99 (7%) Query: 49 LLQAAK-ENDLRL-LKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELA 106 L A K N L L ++ + A G TALH AALY+ + LL++ + Sbjct: 194 LHLAVKVANQASLPLVDFIIQNGGHLDAKAADGNTALHYAALYNQPDCLKLLLKGRALVG 253 Query: 107 KEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSA 145 G+TAL IA + L A A Sbjct: 254 TVNEA-----GETALDIARKKHHKECEELLEQAQAGTFA 287 Score = 40.1 bits (92), Expect = 0.004, Method: Composition-based stats. Identities = 24/106 (22%), Positives = 37/106 (34%), Gaps = 14/106 (13%) Query: 164 EHPLSFA---ACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLL 220 E L A A S +V +I++G + A+ + GNT LH L LL Sbjct: 191 ELVLHLAVKVANQASLPLVDFIIQNGGHLDAKAADGNTALHYAALYNQPDCLK-----LL 245 Query: 221 SYDEHSDHLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHV 266 +L N G T +A + + + L Q + Sbjct: 246 LKGR------ALVGTVNEAGETALDIARKKHHKECEELLEQAQAGT 285 >6DU8-A nrPDB Length = 805 Score = 44.7 bits (104), Expect = 1e-04, Method: Composition-based stats. Identities = 23/131 (17%), Positives = 56/131 (42%), Gaps = 6/131 (4%) Query: 458 LVLGWCSVMYFARGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFHITFQTEDP 517 L W + + + + + + + D++ F + +V +A ++ F T+ Sbjct: 446 LFFAWIKIFKYISFNKTMTQLSSTLARCA-KDILGFAVMFFIVFFAYAQLGYLLFGTQ-- 502 Query: 518 NNLGEFSDYPTALFSTFELFLTIIDGPANYSVDLPFMYCITYAAFAIIATLLMLNLFIAM 577 + FS + +F+ F + L D A + + + + + ++LN+F+A+ Sbjct: 503 --VENFSTFIKCIFTQFRIILGDFDYNAIDNAN-RILGPAYFVTYVFFVFFVLLNMFLAI 559 Query: 578 MGDTHWRVAQE 588 + DT+ V +E Sbjct: 560 INDTYSEVKEE 570 >5UIL-A nrPDB Length = 405 Score = 42.4 bits (98), Expect = 8e-04, Method: Composition-based stats. Identities = 22/100 (22%), Positives = 45/100 (45%), Gaps = 9/100 (9%) Query: 116 VGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGS 175 G + + +A + N+ L++ L+++GA+++ R + +Y+ ++ L G Sbjct: 310 YGWSPVIVAAYHGNIELIKWLVSKGANINDRN-----YKGTTVAMYFKDYML----KSGD 360 Query: 176 EEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQM 215 +++LI+ G D+ D TV L NK M Sbjct: 361 YSGLKMLIDLGLDLTLTDYKDYTVFDYLEKSGNKNLLQYM 400 Score = 40.1 bits (92), Expect = 0.004, Method: Composition-based stats. Identities = 27/137 (19%), Positives = 51/137 (37%), Gaps = 20/137 (14%) Query: 124 AVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVRLLI 183 A + + L+ RA F ++ YG P+ AA G+ E+++ L+ Sbjct: 285 ACKYSDSKYIAKLI--------RAKSILFEKN-----IYGWSPVIVAAYHGNIELIKWLV 331 Query: 184 EHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHSDHLQSLELVPNHQGLTP 243 GA+I ++ G TV K+ +L+ + +++ T Sbjct: 332 SKGANINDRNYKGTTVAMYFKDYMLKSGDYSGLKMLIDLGLDL-------TLTDYKDYTV 384 Query: 244 FKLAGVEGNTVMFQHLM 260 F GN + Q++M Sbjct: 385 FDYLEKSGNKNLLQYMM 401 >5MKE-A nrPDB Length = 968 Score = 41.2 bits (95), Expect = 0.002, Method: Composition-based stats. Identities = 43/255 (16%), Positives = 91/255 (35%), Gaps = 37/255 (14%) Query: 462 WCSVMYFARGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFHITFQTEDPNNLG 521 W + F + + + + + DL F + ++ L +A ++ F T+ + Sbjct: 570 WIKLFKFINFNRTMSQLSTTMSRCA-KDLFGFAIMFFIIFLAYAQLAYLVFGTQ----VD 624 Query: 522 EFSDYPTALFSTFELFLTIIDGPANYSVDLPFMYCITYAAFAIIATLLMLNLFIAMMGDT 581 +FS + +F+ F + L I+ + + I + F ++LN+F+A++ DT Sbjct: 625 DFSTFQECIFTQFRIILGDINFAEIEEAN-RVLGPIYFTTFVFFMFFILLNMFLAIINDT 683 Query: 582 HWRVAQE----------RDELWR-----AQVVATTVMLERKMPRFLWPRSGICGYEYGLG 626 + V + D + + + + L G ++ Sbjct: 684 YSEVKSDLAQQKAEMELSDLIRKGYHKALVKLKLKKNTVDDISESLRQGGGKLNFDELRQ 743 Query: 627 DRWFLRVENHHDQNPLRVLRYVEAFKCSDKEDGQEQLSEKRPSTV------ESGMLSRAS 680 D L+ + H D +EA +DG ++L+E + E L Sbjct: 744 D---LKGKGHTDAE-------IEAIFTKYDQDGDQELTEHEHQQMRDDLEKEREDLDLDH 793 Query: 681 VAFQTPSLSRTTSQS 695 + P SR+ +S Sbjct: 794 SSLPRPMSSRSFPRS 808 >5EK0-A nrPDB Length = 296 Score = 41.2 bits (95), Expect = 0.002, Method: Composition-based stats. Identities = 36/207 (17%), Positives = 72/207 (34%), Gaps = 11/207 (5%) Query: 389 ELVTVTGAVIILLLEIPDIFRVGASRYFGQTILGGPFHVIIITYASLVLLTMVMRLTNMN 448 E++ V I+L I I R+ R + P+ + + ++ M + Sbjct: 60 EVLYWINVVFIILFTIEIILRIYVHR---ISFFKDPWSLFDFVVVIISIVGMFLADLIET 116 Query: 449 GEVVPLSFALV----LGWCSVMYFARGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGF 504 V P F ++ +G + QM + +I + ++ LM + F Sbjct: 117 YFVSPTLFRVIRLARIGRI-LRLVTAVPQMRKIVSALIS--VIPGMLSVIALMTLFFYIF 173 Query: 505 ASAFHITFQTEDPNNLGEFSDYPTALFSTFELFLTIIDGPANYSVDLPFMYCITYAAFAI 564 A F P G + LF L + P+ + + F Sbjct: 174 AIMATQLFGERFPEWFGTLGESFYTLFQVMTLESWSMGIVRPLMEVYPYAWVF-FIPFIF 232 Query: 565 IATLLMLNLFIAMMGDTHWRVAQERDE 591 + T +M+NL +A++ D + Q+ ++ Sbjct: 233 VVTFVMINLVVAIIVDAMAILNQKEEQ 259 >5T4D-A nrPDB Length = 510 Score = 40.9 bits (94), Expect = 0.002, Method: Composition-based stats. Identities = 24/127 (18%), Positives = 55/127 (43%), Gaps = 6/127 (4%) Query: 462 WCSVMYFARGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFHITFQTEDPNNLG 521 W + F + + + + + DL F + ++ L +A ++ F T+ + Sbjct: 378 WIKLFKFINFNRTMSQLSTTMSRCA-KDLFGFAIMFFIIFLAYAQLAYLVFGTQ----VD 432 Query: 522 EFSDYPTALFSTFELFLTIIDGPANYSVDLPFMYCITYAAFAIIATLLMLNLFIAMMGDT 581 +FS + +F+ F + L I+ + + I + F ++LN+F+A++ DT Sbjct: 433 DFSTFQECIFTQFRIILGDINFAEIEEAN-RVLGPIYFTTFVFFMFFILLNMFLAIINDT 491 Query: 582 HWRVAQE 588 + V + Sbjct: 492 YSEVKSD 498 >5WPT-A nrPDB Length = 592 Score = 40.9 bits (94), Expect = 0.002, Method: Composition-based stats. Identities = 45/246 (18%), Positives = 96/246 (39%), Gaps = 29/246 (11%) Query: 370 QKLLQEAYVTHQD-NIRLVGELVTVTGAVI------------ILLLEIPDIF---RVGAS 413 Q+ + H D + RL+ ++V + + LL +F R G Sbjct: 282 QECKHPSVSRHGDNSFRLLFDVVVILTCSLSFLLCARSLLRGFLLQNEFVVFMWRRRGRE 341 Query: 414 RYFGQTI-LGGPFHVIIITYASLVLLTMVMR-------LTNMNGEVVPLSFALVLGWCSV 465 + + ++++++T L + VM+ L + + + L + +L W V Sbjct: 342 ISLWERLEFVNGWYILLVTSDVLTISGTVMKIGIEAKNLASYDVCSILLGTSTLLVWVGV 401 Query: 466 MYFARGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFHITF--QTEDPNNLGEF 523 + + F I ++ +MRFC +AV+ LG+ I +L Sbjct: 402 IRYLTFFHKYNIL-IATLRVALPSVMRFCCCVAVIYLGYCFCGWIVLGPYHVKFRSLSMV 460 Query: 524 SDYPTALFSTFELFLTIIDGPANY-SVDLPFMYCITYA-AFAIIATLLMLNLFIAMMGDT 581 S+ +L + ++F+T A L +++ Y +F + ++L+LFIA++ Sbjct: 461 SECLFSLINGDDMFVTFAAMQAQQGHSSLVWLFSQLYLYSFISLFIYMVLSLFIALITGA 520 Query: 582 HWRVAQ 587 + + Sbjct: 521 YDTIKH 526 >6E7Z-A nrPDB Length = 580 Score = 38.5 bits (88), Expect = 0.009, Method: Composition-based stats. Identities = 43/246 (17%), Positives = 95/246 (38%), Gaps = 29/246 (11%) Query: 370 QKLLQEAYVTHQD-NIRLVGELVTVTGAVIILLLEIPDIFR---------------VGAS 413 Q+ + H D + RL+ ++V + + LL + R G Sbjct: 282 QECKHPSVFQHGDNSFRLLFDVVVILTCSLSFLLCARSLLRGFLLQNEFVGFMWRQRGRV 341 Query: 414 RYFGQTI-LGGPFHVIIITYASLVLLTMVMR-------LTNMNGEVVPLSFALVLGWCSV 465 + + ++++++T L + +M+ L + + + L + +L W V Sbjct: 342 ISLWERLEFVNGWYILLVTSDVLTISGTIMKIGIEAKNLASYDVCSILLGTSTLLVWVGV 401 Query: 466 MYFARGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFHITF--QTEDPNNLGEF 523 + + F I ++ +MRFC +AV+ LG+ I +L Sbjct: 402 IRYLTFFHNYNIL-IATLRVALPSVMRFCCCVAVIYLGYCFCGWIVLGPYHVKFRSLSMV 460 Query: 524 SDYPTALFSTFELFLTIIDGPANY-SVDLPFMYCITYA-AFAIIATLLMLNLFIAMMGDT 581 S+ +L + ++F+T A L +++ Y +F + ++L+LFIA++ Sbjct: 461 SECLFSLINGDDMFVTFAAMQAQQGRSSLVWLFSQLYLYSFISLFIYMVLSLFIALITGA 520 Query: 582 HWRVAQ 587 + + Sbjct: 521 YDTIKH 526 >4DXW-A nrPDB Length = 229 Score = 38.5 bits (88), Expect = 0.010, Method: Composition-based stats. Identities = 24/103 (23%), Positives = 44/103 (42%), Gaps = 9/103 (8%) Query: 481 MIQKMIFGDLMRFCWLMAVVILGFASAFHITFQTEDPNNLGEFSDYPTALFSTFELF-LT 539 ++++ F L+ F L +A+ I F +DP+ G+ LF L Sbjct: 129 SVRRVFFVSLLLFIILYI-----YATMGAILFGNDDPSRWGDLGISLITLFQVLTLSSWE 183 Query: 540 IIDGPANYSVDLPFMYCITYAAFAIIATLLMLNLFIAMMGDTH 582 + P ++Y + +F II ++ +LNL IA++ D Sbjct: 184 TVMLPMQEIYWWSWVY---FFSFIIICSITILNLVIAILVDVV 223 >6D1W-A nrPDB Length = 740 Score = 38.5 bits (88), Expect = 0.010, Method: Composition-based stats. Identities = 24/127 (18%), Positives = 55/127 (43%), Gaps = 6/127 (4%) Query: 462 WCSVMYFARGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFHITFQTEDPNNLG 521 W + F + + + + + DL F + ++ L +A ++ F T+ + Sbjct: 518 WIKLFKFINFNRTMSQLSTTMSRCA-KDLFGFAIMPFIIFLAYAQLAYLVFGTQ----VD 572 Query: 522 EFSDYPTALFSTFELFLTIIDGPANYSVDLPFMYCITYAAFAIIATLLMLNLFIAMMGDT 581 +FS + +F+ F + L I+ + + I + F ++LN+F+A++ DT Sbjct: 573 DFSTFQECIFTQFRIILGDINFAEIEEAN-RVLGPIYFTTFVFFMFFILLNMFLAIINDT 631 Query: 582 HWRVAQE 588 + V + Sbjct: 632 YSEVKSD 638 >3RVY-A nrPDB Length = 285 Score = 38.5 bits (88), Expect = 0.010, Method: Composition-based stats. Identities = 34/199 (17%), Positives = 65/199 (32%), Gaps = 15/199 (7%) Query: 379 THQDNIRLVGELVTVTGAVIILLLEIPDIFRVGASRYFGQTILGGPFHVIIITYASLVLL 438 T + ++ G T+ ++I + I I R+ R + P+ + ++ L+ Sbjct: 51 TSKTFMQSFGVYTTLFNQIVITIFTIEIILRIYVHR---ISFFKDPWSLFDFFVVAISLV 107 Query: 439 TMVMRLTNMNGEVVPLSFALVLGWCSVMYFARGFQMLGPFTIMIQKMIFGDLMRFCWLMA 498 + V F LV QM + +I + ++ LM Sbjct: 108 PTSSGFEILRVLRVLRLFRLV---------TAVPQMRKIVSALIS--VIPGMLSVIALMT 156 Query: 499 VVILGFASAFHITFQTEDPNNLGEFSDYPTALFSTFELFLTIIDGPANYSVDLPFMYCIT 558 + FA F P G + LF L + P+ + Sbjct: 157 LFFYIFAIMATQLFGERFPEWFGTLGESFYTLFQVMTLESWSMGIVRPLMEVYPYAWVF- 215 Query: 559 YAAFAIIATLLMLNLFIAM 577 + F + T +M+NL +A+ Sbjct: 216 FIPFIFVVTFVMINLVVAI 234 >6AYG-A nrPDB Length = 558 Score = 37.4 bits (85), Expect = 0.020, Method: Composition-based stats. Identities = 38/192 (19%), Positives = 77/192 (40%), Gaps = 23/192 (11%) Query: 444 LTNMNGEVVPLSFALVLGWCSVMYFARGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILG 503 LT+ + + L + +L W V+ + F + +Q +++RFC A++ LG Sbjct: 372 LTSYDVCSILLGTSTMLVWLGVIRYLGFFAKYNLLILTLQAA-LPNVIRFCCCAAMIYLG 430 Query: 504 FASAFHITFQTEDPNNLGEFSDYPTALFSTFELFLTIIDGP--------ANYSVDLPFMY 555 + I LG + D +L E ++I+G L +++ Sbjct: 431 YCFCGWIV--------LGPYHDKFRSLNMVSECLFSLINGDDMFATFAKMQQKSYLVWLF 482 Query: 556 CITYA-AFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVATTVMLERKMPRFLWP 614 Y +F + ++L+LFIA++ DT+ + Q + + + + T + + +P Sbjct: 483 SRIYLYSFISLFIYMILSLFIALITDTYETIKQYQQDGFPETELRTFISECKDLP----- 537 Query: 615 RSGICGYEYGLG 626 SG E Sbjct: 538 NSGKYRLEDDPP 549 >4XD0-A nrPDB Length = 417 Score = 37.4 bits (85), Expect = 0.023, Method: Composition-based stats. Identities = 19/99 (19%), Positives = 44/99 (44%), Gaps = 9/99 (9%) Query: 117 GQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSE 176 G + + IA + N++++ L+++G +++ R + +Y+ ++ L G E Sbjct: 324 GWSPIIIAAYHGNMDVIEWLVSKGVNINDRN-----YKGTTVAMYFKDYMLRSGNYTGLE 378 Query: 177 EIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQM 215 ++ L G D+ +D+ G +V + N M Sbjct: 379 NLINL----GLDLFLKDNEGLSVFDYMRKNKNIELFNFM 413 Score = 37.4 bits (85), Expect = 0.024, Method: Composition-based stats. Identities = 21/101 (20%), Positives = 40/101 (39%), Gaps = 15/101 (14%) Query: 163 GEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVL----HILILQPNKTFACQMYNL 218 G P+ AA G+ +++ L+ G +I ++ G TV ++ N T + NL Sbjct: 324 GWSPIIIAAYHGNMDVIEWLVSKGVNINDRNYKGTTVAMYFKDYMLRSGNYTGLENLINL 383 Query: 219 LLSYDEHSDHLQSLELVPNHQGLTPFKLAGVEGNTVMFQHL 259 L + +++GL+ F N +F + Sbjct: 384 GLDL-----------FLKDNEGLSVFDYMRKNKNIELFNFM 413 >6BWI-A nrPDB Length = 977 Score = 35.5 bits (80), Expect = 0.089, Method: Composition-based stats. Identities = 33/164 (20%), Positives = 58/164 (35%), Gaps = 40/164 (24%) Query: 473 QMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFHITFQTEDPNNLGEFSDYPTALFS 532 + LGP +++ KM D+ F + + V ++ + A + D SD+P+ L Sbjct: 715 KQLGPKIVIVSKM-MKDVFFFLFFLGVWLVAYGVATEGLLRPRD-------SDFPSILRR 766 Query: 533 TF-ELFLTIIDGPANYSVDLPFM-------------------YCITYAAFA--------- 563 F +L I +D+ M + +A Sbjct: 767 VFYRPYLQIFGQIPQEDMDVALMEHSNCSSEPGFWAHPPGAQAGTCVSQYANWLVVLLLV 826 Query: 564 ---IIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVATTVML 604 ++A +L++NL IAM T +V D W+AQ Sbjct: 827 IFLLVANILLVNLLIAMFSYTFGKVQGNSDLYWKAQRYRLIREF 870 >4GX0-A nrPDB Length = 565 Score = 34.7 bits (78), Expect = 0.14, Method: Composition-based stats. Identities = 11/81 (13%), Positives = 29/81 (35%) Query: 491 MRFCWLMAVVILGFASAFHITFQTEDPNNLGEFSDYPTALFSTFELFLTIIDGPANYSVD 550 ++ L +L A+ F+ + G + ++ T + T+ G + D Sbjct: 17 LKVLLLYCAFLLVMLLAYASIFRYLMWHLEGRAYSFMAGIYWTITVMTTLGFGDITFESD 76 Query: 551 LPFMYCITYAAFAIIATLLML 571 +++ +I ++L Sbjct: 77 AGYLFASIVTVSGVIFLDIIL 97 >6N4I-A nrPDB Length = 288 Score = 34.7 bits (78), Expect = 0.17, Method: Composition-based stats. Identities = 33/180 (18%), Positives = 64/180 (35%), Gaps = 10/180 (5%) Query: 399 ILLLEIPDIFRVGASRYFGQTILGGPFHVIIITYASLVLLTMV-MRLTNMNGEVVPLSFA 457 ++ I I + + P+ + + +V L++V + L ++ G V SF Sbjct: 67 LVFTGIFAIEIILRIYVHRISFFKDPWS---LFDSLIVTLSLVELFLADVEGLSVLRSFR 123 Query: 458 LVLGWCSVMYFARGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFHITFQTEDP 517 L+ + V QM + +I + ++ LM + FA F P Sbjct: 124 LLRVFRLVTAVP---QMRKIVSALIS--VIPGMLSVIALMTLFFYIFAIMATQLFGERFP 178 Query: 518 NNLGEFSDYPTALFSTFELFLTIIDGPANYSVDLPFMYCITYAAFAIIATLLMLNLFIAM 577 G + LF L + P+ + + F + T +M+NL +A+ Sbjct: 179 EWFGTLGESFYTLFQVMTLESWSMGIVRPLMEVYPYAWVF-FIPFIFVVTFVMINLVVAI 237 >5E1J-A nrPDB Length = 741 Score = 32.8 bits (73), Expect = 0.51, Method: Composition-based stats. Identities = 25/104 (24%), Positives = 46/104 (44%), Gaps = 7/104 (6%) Query: 486 IFGDLMRFCWLMAVVILGFASAFHI-TFQTEDPNN---LGEFSDYPTALFSTFELFL--- 538 IF L +C + V G +A + F+TE + L F+DYP + + F L + Sbjct: 572 IFCVLCIYCSIGVQVFGGLVNAGNKKLFETELAEDDYLLFNFNDYPNGMVTLFNLLVMGN 631 Query: 539 TIIDGPANYSVDLPFMYCITYAAFAIIATLLMLNLFIAMMGDTH 582 + + + + + +F +I LL+LNL +A + + Sbjct: 632 WQVWMESYKDLTGTWWSITYFVSFYVITILLLLNLVVAFVLEAF 675 >2GBW-A nrPDB Length = 454 Score = 31.6 bits (70), Expect = 1.1, Method: Composition-based stats. Identities = 30/150 (20%), Positives = 50/150 (33%), Gaps = 23/150 (15%) Query: 180 RLLIEHGAD------IRAQDSLGNTVLHILILQPN-KTFACQMYNLLLSYDEHSDHLQSL 232 ++++ H +D I + GN + H N K F C + + D L Sbjct: 62 KVILSHQSDGTFRAFINSCSHRGNQICHA--DSGNAKAFVCNYHGWVFGQDGSL-VDVPL 118 Query: 233 ELVPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLTSTLYDLTEIDSWGEELSF 292 E H L KLA ++ + P +L D GE + Sbjct: 119 ESRCYHNSLDKQKLAAKSVRVETYK------GFIFGCHDPEAPSLEDYL-----GEFRYY 167 Query: 293 LELVVSSKKREARQILEQTPVKELVSFKWK 322 L+ + ++L P+K L+ WK Sbjct: 168 LDTIWEGAG-GGMELLG-PPMKSLLQCNWK 195 >3G2F-A nrPDB Length = 336 Score = 30.8 bits (68), Expect = 2.4, Method: Composition-based stats. Identities = 23/142 (16%), Positives = 48/142 (33%), Gaps = 20/142 (14%) Query: 34 DRVNMLQQERIRDSPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLE 93 +R N + ++ I PL++ + + ++ ++ R L V Y N Sbjct: 48 NRQNFINEKNIYRVPLME-----HDNIARFIVGDERVTADGRMEY----LLVMEYYPNGS 98 Query: 94 AATLLMEAAPE-LAKEPALCEPFVGQTALHI----------AVMNQNLNLVRALLARGAS 142 L + ++ G LH A+ +++LN L+ + Sbjct: 99 LCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGT 158 Query: 143 VSARATGAAFRRSPHNLIYYGE 164 G + R + + L+ GE Sbjct: 159 CVISDFGLSMRLTGNRLVRPGE 180 >2FT0-A nrPDB Length = 235 Score = 30.1 bits (66), Expect = 3.3, Method: Composition-based stats. Identities = 12/51 (23%), Positives = 20/51 (39%) Query: 101 AAPELAKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAA 151 A EL + G+T L +A N ++ + GA+V + A Sbjct: 184 AGAELMQTALNWAYARGKTTLRVATQMGNTAALKRYIQSGANVESTAYWLY 234 >3CO4-A nrPDB Length = 312 Score = 30.1 bits (66), Expect = 3.3, Method: Composition-based stats. Identities = 22/97 (22%), Positives = 40/97 (41%), Gaps = 7/97 (7%) Query: 2 GACPPKAKGPWA-QLQKLLISWPVGEQDWEQYRDRVNMLQQER--IRDSPLLQAAKENDL 58 G K K W +WEQY D +N++ +R D P+ A+ ++ + Sbjct: 132 GLYLAKEKNMLMTCAVNS--RWLNYGTEWEQYFDYINLMSYDRGAFTDKPVQHASYDDFV 189 Query: 59 RLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAA 95 + LK N+ C + VG + + ++L+ A Sbjct: 190 KDLK--YWNEQCRASKSKIVGGLPFYGYSWEESLQGA 224 >2N4X-A nrPDB Length = 208 Score = 28.9 bits (63), Expect = 7.2, Method: Composition-based stats. Identities = 16/86 (18%), Positives = 34/86 (39%), Gaps = 2/86 (2%) Query: 487 FGDLMRFCWLMAVVILGFASAFHITFQTEDPNNLGEFS-DYPTALFSTFELFLTIIDGPA 545 FG L+ F WL A++ A T +E+P + + + + F++ + Sbjct: 117 FGMLLAFLWLPAILPFA-GIAISQTLLSENPLVMLSYGLGMAVTIAAVFKMGEKFVKANF 175 Query: 546 NYSVDLPFMYCITYAAFAIIATLLML 571 + + Y A+ + +L+L Sbjct: 176 QLIRKVTGAIVLLYLAYFALTEVLLL 201 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.315 0.130 0.342 Lambda K H 0.267 0.0398 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 25,281,015 Number of Sequences: 36641 Number of extensions: 925654 Number of successful extensions: 4327 Number of sequences better than 10.0: 99 Number of HSP's better than 10.0 without gapping: 135 Number of HSP's successfully gapped in prelim test: 47 Number of HSP's that attempted gapping in prelim test: 2789 Number of HSP's gapped (non-prelim): 500 length of query: 730 length of database: 10,336,785 effective HSP length: 104 effective length of query: 626 effective length of database: 6,526,121 effective search space: 4085351746 effective search space used: 4085351746 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 40 (21.1 bits) S2: 63 (28.9 bits)