BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q9WV60 (420 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 5AIR-A nrPDB 863 0.0 4E7W-A nrPDB 526 e-150 3EB0-A nrPDB 348 3e-96 3E3P-A nrPDB 328 3e-90 4QTB-A nrPDB 181 7e-46 3NIZ-A nrPDB 180 9e-46 1UA2-A nrPDB 180 1e-45 4QNY-A nrPDB 179 1e-45 2BPM-A nrPDB 175 4e-44 4BBM-A nrPDB 173 1e-43 4IC8-A nrPDB 173 2e-43 6DTL-A nrPDB 172 3e-43 4MYG-A nrPDB 172 4e-43 4ZSG-A nrPDB 171 7e-43 5NGU-A nrPDB 170 1e-42 4AGU-A nrPDB 167 1e-41 3GC9-A nrPDB 167 1e-41 5Z33-A nrPDB 166 3e-41 3OZ6-A nrPDB 166 3e-41 4BGQ-A nrPDB 165 3e-41 1CM8-A nrPDB 164 5e-41 2F9G-A nrPDB 162 2e-40 1V0B-A nrPDB 162 3e-40 5G6V-A nrPDB 161 5e-40 4AU8-A nrPDB 160 7e-40 4EWQ-A nrPDB 158 5e-39 3OHT-A nrPDB 155 3e-38 2I6L-A nrPDB 154 5e-38 6GU6-A nrPDB 152 2e-37 4KRC-A nrPDB 151 6e-37 3GC0-A nrPDB 146 1e-35 3PG1-A nrPDB 143 1e-34 3RP9-A nrPDB 143 1e-34 3ZDU-A nrPDB 142 4e-34 6O6Q-A nrPDB 137 6e-33 5AWM-A nrPDB 137 1e-32 4O2Z-A nrPDB 136 2e-32 4NST-A nrPDB 136 2e-32 2PVN-A nrPDB 135 3e-32 2XS0-A nrPDB 134 9e-32 1JNK-A nrPDB 132 2e-31 5EFQ-A nrPDB 132 3e-31 4MD7-E nrPDB 130 1e-30 3E7O-A nrPDB 130 1e-30 6HMD-A nrPDB 129 2e-30 3N9X-A nrPDB 129 3e-30 3FI2-A nrPDB 128 4e-30 6EII-A nrPDB 128 4e-30 1G3N-A nrPDB 127 6e-30 4LFI-A nrPDB 124 6e-29 5XVU-A nrPDB 124 7e-29 3MIA-A nrPDB 123 1e-28 2W96-B nrPDB 123 2e-28 5Y86-A nrPDB 122 2e-28 3NIE-A nrPDB 122 3e-28 4MVF-A nrPDB 122 3e-28 2WO6-A nrPDB 121 5e-28 5ZTN-A nrPDB 121 6e-28 4CRL-A nrPDB 118 5e-27 5JN2-A nrPDB 110 1e-24 4IAN-A nrPDB 107 9e-24 3MA6-A nrPDB 106 2e-23 3F3Z-A nrPDB 105 3e-23 5XZW-A nrPDB 105 4e-23 2Z7Q-A nrPDB 104 6e-23 6FDY-U nrPDB 104 9e-23 5D9K-A nrPDB 103 1e-22 4RGJ-A nrPDB 102 2e-22 4PDS-A nrPDB 100 2e-21 4YZB-A nrPDB 99 5e-21 5YKS-A nrPDB 96 2e-20 3HZT-A nrPDB 96 3e-20 3DXN-A nrPDB 96 3e-20 3D2K-A nrPDB 96 4e-20 6E2O-A nrPDB 95 5e-20 4WNO-A nrPDB 95 5e-20 4D28-A nrPDB 95 6e-20 2WQN-A nrPDB 94 8e-20 4CZT-A nrPDB 94 9e-20 4B6L-A nrPDB 94 9e-20 1U5R-A nrPDB 94 1e-19 2YCR-A nrPDB 94 1e-19 4UZD-A nrPDB 93 2e-19 2GCD-A nrPDB 92 3e-19 6QAU-A nrPDB 92 5e-19 2JD5-A nrPDB 92 5e-19 3NCG-A nrPDB 92 5e-19 6FYV-A nrPDB 91 7e-19 5WAX-A nrPDB 91 7e-19 3I6U-A nrPDB 91 8e-19 3IS5-A nrPDB 91 1e-18 3ORZ-A nrPDB 90 2e-18 5IG1-A nrPDB 90 2e-18 4FIE-A nrPDB 89 3e-18 5X8I-B nrPDB 89 3e-18 4I6B-A nrPDB 89 3e-18 3QA8-A nrPDB 89 4e-18 3HKO-A nrPDB 89 5e-18 4JDH-A nrPDB 89 5e-18 2Q0N-A nrPDB 88 7e-18 4XBR-A nrPDB 88 8e-18 3UC3-A nrPDB 87 9e-18 2X4F-A nrPDB 87 1e-17 4YNZ-A nrPDB 87 1e-17 3DFA-A nrPDB 87 1e-17 2F57-A nrPDB 86 2e-17 3HDN-A nrPDB 86 2e-17 4L42-A nrPDB 86 3e-17 4JXF-A nrPDB 86 3e-17 4KS7-A nrPDB 86 4e-17 5KZ7-A nrPDB 86 4e-17 2HAK-A nrPDB 86 4e-17 5ES1-A nrPDB 86 4e-17 6C9D-A nrPDB 86 4e-17 2BRG-A nrPDB 86 4e-17 1VZO-A nrPDB 85 5e-17 5N23-A nrPDB 85 5e-17 2BDW-A nrPDB 85 6e-17 4B8L-A nrPDB 85 6e-17 5F9E-A nrPDB 85 6e-17 3ZUT-A nrPDB 85 7e-17 4AF3-A nrPDB 85 8e-17 2QNJ-A nrPDB 84 1e-16 3MN3-A nrPDB 84 1e-16 3LIJ-A nrPDB 84 1e-16 3KK8-A nrPDB 84 2e-16 4WB7-A nrPDB 83 2e-16 3BHH-A nrPDB 83 2e-16 5X3F-B nrPDB 83 3e-16 5FG8-A nrPDB 82 3e-16 6E9W-A nrPDB 82 4e-16 4FR4-A nrPDB 82 4e-16 1PHK-A nrPDB 82 4e-16 3ALO-A nrPDB 82 4e-16 4CQG-A nrPDB 82 5e-16 1S9I-A nrPDB 82 5e-16 1NY3-A nrPDB 82 5e-16 4FG9-A nrPDB 82 5e-16 4RLP-A nrPDB 82 6e-16 4C0T-A nrPDB 82 6e-16 2OZA-A nrPDB 82 6e-16 6ED6-A nrPDB 81 8e-16 4D2V-A nrPDB 81 9e-16 3KA0-A nrPDB 81 9e-16 2V7O-A nrPDB 81 9e-16 2JC6-A nrPDB 81 1e-15 2JAM-A nrPDB 81 1e-15 5U6Y-A nrPDB 80 1e-15 3UIU-A nrPDB 80 1e-15 3DB8-A nrPDB 80 1e-15 6HXF-B nrPDB 80 2e-15 3UDB-A nrPDB 80 2e-15 3Q5I-A nrPDB 80 2e-15 2A1A-B nrPDB 80 2e-15 5J5T-A nrPDB 80 2e-15 2W4O-A nrPDB 79 3e-15 2Y7J-A nrPDB 79 3e-15 6BDL-A nrPDB 79 3e-15 5D7A-A nrPDB 79 3e-15 2WTK-C nrPDB 79 3e-15 2VZ6-A nrPDB 79 3e-15 5KKR-C nrPDB 79 4e-15 4U41-A nrPDB 79 4e-15 2VN9-A nrPDB 79 4e-15 4RA4-A nrPDB 79 4e-15 5UNP-A nrPDB 79 5e-15 5UUU-A nrPDB 79 5e-15 4KIK-B nrPDB 79 5e-15 3COM-A nrPDB 79 5e-15 5JZN-A nrPDB 79 5e-15 2W1I-A nrPDB 78 6e-15 4APC-A nrPDB 78 7e-15 1FOT-A nrPDB 78 7e-15 3PVW-A nrPDB 78 7e-15 5VO2-A nrPDB 78 8e-15 2OU7-A nrPDB 78 8e-15 4OLI-A nrPDB 78 9e-15 3IO7-A nrPDB 77 9e-15 3RAW-A nrPDB 77 1e-14 4F9B-A nrPDB 77 1e-14 3EQC-A nrPDB 77 1e-14 3NYO-A nrPDB 77 1e-14 4GS6-A nrPDB 77 1e-14 5LOH-A nrPDB 77 2e-14 3SOA-A nrPDB 76 3e-14 4HVI-A nrPDB 76 3e-14 6DBM-A nrPDB 76 3e-14 3Q53-A nrPDB 76 4e-14 5DYK-A nrPDB 75 4e-14 4EQM-A nrPDB 75 4e-14 4J52-A nrPDB 75 5e-14 3PFQ-A nrPDB 75 5e-14 6FD3-A nrPDB 75 5e-14 5VD3-A nrPDB 75 5e-14 5TUR-A nrPDB 75 6e-14 3DAK-A nrPDB 74 8e-14 4TNB-A nrPDB 74 8e-14 2JDO-A nrPDB 74 8e-14 5HI2-A nrPDB 74 1e-13 2I0E-A nrPDB 74 1e-13 4LG4-A nrPDB 74 2e-13 3ORP-A nrPDB 74 2e-13 2BUJ-A nrPDB 73 2e-13 4C59-A nrPDB 73 2e-13 4E20-A nrPDB 73 2e-13 6AO5-A nrPDB 73 2e-13 4EUU-A nrPDB 73 2e-13 4AN9-A nrPDB 73 2e-13 2J90-A nrPDB 73 2e-13 4AW2-A nrPDB 73 3e-13 1ZXE-A nrPDB 73 3e-13 3BGP-A nrPDB 73 3e-13 3KN6-A nrPDB 73 3e-13 4EUT-A nrPDB 73 3e-13 2UV2-A nrPDB 73 3e-13 4UYA-A nrPDB 72 3e-13 3TXO-A nrPDB 72 3e-13 3A8W-A nrPDB 72 4e-13 3DLS-A nrPDB 72 4e-13 2VD5-A nrPDB 72 4e-13 3VN9-A nrPDB 72 4e-13 4UY9-A nrPDB 72 4e-13 3H4J-B nrPDB 72 4e-13 4RC3-A nrPDB 72 4e-13 5KCV-A nrPDB 72 4e-13 6CCF-A nrPDB 72 4e-13 3DTC-A nrPDB 72 5e-13 5DBX-A nrPDB 72 5e-13 6BXI-A nrPDB 72 5e-13 3FXW-A nrPDB 72 5e-13 4IDT-A nrPDB 72 6e-13 2HW6-A nrPDB 72 6e-13 3MV5-A nrPDB 72 6e-13 4JLC-A nrPDB 72 6e-13 3TKU-A nrPDB 72 6e-13 4CFF-A nrPDB 71 7e-13 6NT9-A nrPDB 71 8e-13 4REW-A nrPDB 71 8e-13 4PL5-B nrPDB 71 8e-13 5TQX-A nrPDB 71 9e-13 5EZV-A nrPDB 71 1e-12 3LLT-A nrPDB 71 1e-12 2XIK-A nrPDB 70 1e-12 5X5O-A nrPDB 70 2e-12 2XNP-A nrPDB 70 2e-12 4CFH-A nrPDB 70 2e-12 6CMJ-A nrPDB 70 2e-12 4RED-A nrPDB 70 2e-12 3TAC-A nrPDB 69 3e-12 4NIF-A nrPDB 69 3e-12 3FME-A nrPDB 69 3e-12 6O8B-A nrPDB 69 4e-12 4IX6-A nrPDB 69 4e-12 6CQF-A nrPDB 69 4e-12 3UIM-A nrPDB 69 5e-12 6HV0-A nrPDB 69 5e-12 5FET-A nrPDB 69 5e-12 4QMW-A nrPDB 68 6e-12 1KOB-A nrPDB 68 8e-12 5HVK-A nrPDB 68 9e-12 3UTO-A nrPDB 68 9e-12 5HIE-A nrPDB 67 1e-11 5H2U-A nrPDB 67 1e-11 1KOA-A nrPDB 67 1e-11 5B2L-A nrPDB 67 1e-11 1TKI-A nrPDB 67 1e-11 2YZA-A nrPDB 67 1e-11 4JG6-A nrPDB 67 2e-11 3M42-A nrPDB 67 2e-11 4X7Q-B nrPDB 67 2e-11 3HNG-A nrPDB 66 3e-11 4CSV-A nrPDB 66 3e-11 4G3E-A nrPDB 66 3e-11 4FZF-B nrPDB 66 3e-11 4M7I-A nrPDB 66 3e-11 4TPT-A nrPDB 65 4e-11 5YV8-A nrPDB 65 5e-11 4X3F-A nrPDB 65 5e-11 3C51-A nrPDB 65 6e-11 3PPZ-A nrPDB 65 6e-11 5TOS-A nrPDB 65 6e-11 3LMG-A nrPDB 65 7e-11 6CTH-A nrPDB 65 8e-11 4LQP-A nrPDB 64 9e-11 1ZWS-A nrPDB 64 9e-11 3OMV-A nrPDB 64 1e-10 5IKW-A nrPDB 64 1e-10 2A27-A nrPDB 64 1e-10 4OW8-A nrPDB 64 1e-10 6DBN-A nrPDB 64 1e-10 5TE0-A nrPDB 64 2e-10 3GUB-A nrPDB 64 2e-10 6GQK-A nrPDB 63 2e-10 4H1J-A nrPDB 63 2e-10 6B2Q-A nrPDB 62 3e-10 2RIO-A nrPDB 62 4e-10 2PZI-A nrPDB 62 6e-10 2YAB-A nrPDB 61 8e-10 3VHK-A nrPDB 61 8e-10 4Y12-A nrPDB 60 1e-09 3CJF-A nrPDB 60 2e-09 4EBW-A nrPDB 60 2e-09 5LPZ-A nrPDB 60 2e-09 4PWN-A nrPDB 60 2e-09 3QD2-B nrPDB 60 2e-09 5LPV-A nrPDB 59 3e-09 2J0K-A nrPDB 59 3e-09 6CKI-A nrPDB 59 3e-09 4F0G-A nrPDB 59 3e-09 3SXS-A nrPDB 59 5e-09 6GVJ-A nrPDB 59 5e-09 4YHJ-A nrPDB 59 5e-09 5MJB-A nrPDB 59 6e-09 2ZMD-A nrPDB 59 6e-09 4PDO-A nrPDB 59 6e-09 4CRS-A nrPDB 59 6e-09 6J5U-C nrPDB 58 7e-09 5UIU-A nrPDB 58 9e-09 5O2C-A nrPDB 58 9e-09 3G0E-A nrPDB 58 1e-08 2PMN-X nrPDB 57 1e-08 3HMP-A nrPDB 57 1e-08 5O2B-A nrPDB 57 1e-08 4P5Q-A nrPDB 57 1e-08 3PLS-A nrPDB 57 2e-08 5GNK-A nrPDB 57 2e-08 3QGY-A nrPDB 57 2e-08 5GRN-A nrPDB 57 2e-08 5U6B-A nrPDB 56 2e-08 2R2P-A nrPDB 56 4e-08 5AP3-A nrPDB 55 4e-08 3LZB-A nrPDB 55 4e-08 3BBT-B nrPDB 55 5e-08 1FVR-A nrPDB 55 5e-08 3KUL-B nrPDB 55 6e-08 4XCU-A nrPDB 55 7e-08 4JRN-A nrPDB 55 8e-08 3TT0-A nrPDB 55 8e-08 4K33-A nrPDB 55 8e-08 3GQL-A nrPDB 54 1e-07 2X7G-A nrPDB 54 1e-07 2QLU-A nrPDB 54 1e-07 2PSQ-A nrPDB 54 1e-07 5A46-A nrPDB 54 1e-07 5O0Y-A nrPDB 54 1e-07 4NEU-A nrPDB 54 1e-07 5J0A-A nrPDB 54 2e-07 5EG3-A nrPDB 53 2e-07 5M07-A nrPDB 53 2e-07 4OTD-A nrPDB 53 2e-07 4YFF-A nrPDB 53 2e-07 3BEA-A nrPDB 53 3e-07 3DKO-A nrPDB 53 3e-07 4E93-A nrPDB 53 3e-07 3A4O-X nrPDB 53 3e-07 4XEY-B nrPDB 52 3e-07 5L6P-A nrPDB 52 3e-07 5XD6-A nrPDB 52 4e-07 4BTK-A nrPDB 52 4e-07 4HZS-A nrPDB 52 4e-07 2H34-A nrPDB 52 4e-07 4NFN-A nrPDB 52 4e-07 1U54-B nrPDB 52 5e-07 2WTK-B nrPDB 52 5e-07 2DQ7-X nrPDB 52 5e-07 3LM0-A nrPDB 52 5e-07 3SOC-A nrPDB 52 5e-07 2Y6O-A nrPDB 52 6e-07 5FQD-C nrPDB 52 7e-07 2FO0-A nrPDB 51 7e-07 4FL3-A nrPDB 51 7e-07 2VWV-A nrPDB 51 8e-07 4LRM-A nrPDB 51 9e-07 6NPU-A nrPDB 51 9e-07 4XUF-A nrPDB 51 1e-06 2OZO-A nrPDB 51 1e-06 4RT7-A nrPDB 50 1e-06 5X02-A nrPDB 50 1e-06 1U59-A nrPDB 50 2e-06 4R7H-A nrPDB 50 2e-06 3ZBF-A nrPDB 50 2e-06 3G2F-A nrPDB 50 2e-06 4Y83-A nrPDB 50 2e-06 5C26-A nrPDB 50 2e-06 2OGV-A nrPDB 50 2e-06 2HK5-A nrPDB 50 2e-06 3SV0-A nrPDB 50 3e-06 3KRL-A nrPDB 49 4e-06 2H8H-A nrPDB 49 4e-06 1JPA-A nrPDB 49 4e-06 1AD5-A nrPDB 49 5e-06 5X18-A nrPDB 49 5e-06 4XHL-A nrPDB 49 5e-06 5AMN-A nrPDB 49 6e-06 4WUA-A nrPDB 48 6e-06 5OAT-A nrPDB 48 7e-06 3AOX-A nrPDB 48 8e-06 6F3F-A nrPDB 48 9e-06 2Y4I-B nrPDB 47 1e-05 3C1X-A nrPDB 47 2e-05 2PL0-A nrPDB 47 2e-05 5U6C-A nrPDB 47 2e-05 1K9A-A nrPDB 47 2e-05 5L2Q-C nrPDB 46 2e-05 5WNO-A nrPDB 46 2e-05 1BYG-A nrPDB 46 3e-05 5FM2-A nrPDB 46 3e-05 5HLW-A nrPDB 46 3e-05 2QKW-B nrPDB 46 3e-05 5X1R-A nrPDB 46 3e-05 4M66-A nrPDB 46 4e-05 6G4J-A nrPDB 45 5e-05 5SYS-A nrPDB 45 6e-05 3QUP-A nrPDB 45 6e-05 4TN6-A nrPDB 45 7e-05 5VC6-A nrPDB 45 7e-05 1LUF-A nrPDB 45 7e-05 4XLV-A nrPDB 45 8e-05 4XHH-A nrPDB 45 8e-05 2CMW-A nrPDB 45 8e-05 5UV4-A nrPDB 44 1e-04 5E8V-A nrPDB 44 1e-04 3PP0-A nrPDB 44 2e-04 3BYV-A nrPDB 44 2e-04 5CLR-A nrPDB 44 2e-04 5AR8-A nrPDB 43 3e-04 3DZO-A nrPDB 42 6e-04 2CHL-A nrPDB 42 6e-04 3I81-A nrPDB 42 7e-04 2C47-A nrPDB 41 0.001 6BFN-A nrPDB 41 0.001 5WNL-A nrPDB 39 0.003 4NT4-A nrPDB 39 0.004 3Q4U-A nrPDB 39 0.006 1CSN-A nrPDB 38 0.007 4CI6-B nrPDB 37 0.015 1PY5-A nrPDB 37 0.017 5C01-A nrPDB 37 0.018 4WOV-A nrPDB 37 0.020 4O1O-A nrPDB 36 0.025 5VDK-A nrPDB 36 0.032 4AZV-A nrPDB 35 0.075 2RSV-A nrPDB 35 0.078 4AZW-A nrPDB 34 0.12 2LAV-A nrPDB 34 0.15 2W1Z-A nrPDB 33 0.17 3ZZW-A nrPDB 33 0.24 5CEK-A nrPDB 33 0.25 5UU1-A nrPDB 33 0.28 6J6I-B nrPDB 33 0.31 6DC0-A nrPDB 32 0.35 3MDY-A nrPDB 32 0.39 4OAU-C nrPDB 32 0.60 4H05-A nrPDB 32 0.66 5JFQ-A nrPDB 31 0.78 4BWP-A nrPDB 30 1.6 5VE6-A nrPDB 30 1.7 6EQI-C nrPDB 29 3.6 6FUC-A nrPDB 29 3.9 4L00-A nrPDB 29 4.3 5OWX-1 nrPDB 29 4.4 4M69-B nrPDB 29 4.4 3ENH-A nrPDB 28 5.3 >5AIR-A nrPDB Length = 430 Score = 863 bits (2230), Expect = 0.0, Method: Compositional matrix adjust. Identities = 417/419 (99%), Positives = 417/419 (99%) Query: 2 SGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKV 61 S RPRTTSFAESCKPVQQPSAFGSMKVS DKDGSKVTTVVATPGQGPDRPQEVSYTDTKV Sbjct: 12 SSRPRTTSFAESCKPVQQPSAFGSMKVSIDKDGSKVTTVVATPGQGPDRPQEVSYTDTKV 71 Query: 62 IGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGE 121 IGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGE Sbjct: 72 IGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGE 131 Query: 122 KKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRD 181 KKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRD Sbjct: 132 KKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRD 191 Query: 182 IKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVW 241 IKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVW Sbjct: 192 IKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVW 251 Query: 242 SAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPW 301 SAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPW Sbjct: 252 SAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPW 311 Query: 302 TKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFN 361 TKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFN Sbjct: 312 TKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFN 371 Query: 362 FTTQELSSNPPLATILIPPHARIQAAASPPANATAASDTNAGDRGQTNNAASASASNST 420 FTTQELSSNPPLATILIPPHARIQAAASPPANATAASDTNAGDRGQTNNAASASASNST Sbjct: 372 FTTQELSSNPPLATILIPPHARIQAAASPPANATAASDTNAGDRGQTNNAASASASNST 430 >4E7W-A nrPDB Length = 394 Score = 526 bits (1356), Expect = e-150, Method: Compositional matrix adjust. Identities = 248/363 (68%), Positives = 304/363 (83%), Gaps = 2/363 (0%) Query: 23 FGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELV 82 +K++ D +KV V+A+ G+ ++ +E++YT+ KVIGNGSFGVV+QAKL +S E V Sbjct: 10 LNGVKLNPLDDPNKVIKVLASDGKTGEQ-REIAYTNCKVIGNGSFGVVFQAKLVESDE-V 67 Query: 83 AIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRV 142 AIKKVLQDKRFKNRELQIMR + H N+V L+ FFYS+G+KKDEV+LNLVL+YVPETVYR Sbjct: 68 AIKKVLQDKRFKNRELQIMRIVKHPNVVDLKAFFYSNGDKKDEVFLNLVLEYVPETVYRA 127 Query: 143 ARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFG 202 +RHY++ KQT+P++ +KLYMYQL RSLAYIHS GICHRDIKPQNLLLDP + VLKL DFG Sbjct: 128 SRHYAKLKQTMPMLLIKLYMYQLLRSLAYIHSIGICHRDIKPQNLLLDPPSGVLKLIDFG 187 Query: 203 SAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSG 262 SAK L+ GEPNVSYICSRYYRAPELIFGAT+YT++ID+WS GCV+AEL+ GQP+FPG+SG Sbjct: 188 SAKILIAGEPNVSYICSRYYRAPELIFGATNYTTNIDIWSTGCVMAELMQGQPLFPGESG 247 Query: 263 VDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLE 322 +DQLVEIIKVLGTP+REQI+ MNPNY E KFPQI+ HP++KVFRPRTPP+AI L SRLLE Sbjct: 248 IDQLVEIIKVLGTPSREQIKTMNPNYMEHKFPQIRPHPFSKVFRPRTPPDAIDLISRLLE 307 Query: 323 YTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHA 382 YTP+ARLT +EA H FFDELR ++PNGR+ P LFN+T +ELS P L + L+P HA Sbjct: 308 YTPSARLTAIEALCHPFFDELRTGEARMPNGRELPPLFNWTKEELSVRPDLISRLVPQHA 367 Query: 383 RIQ 385 + Sbjct: 368 EAE 370 >3EB0-A nrPDB Length = 383 Score = 348 bits (892), Expect = 3e-96, Method: Compositional matrix adjust. Identities = 166/357 (46%), Positives = 237/357 (66%), Gaps = 41/357 (11%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYF 115 Y+ K +G GSFG+V + +SG+ A+KKVLQD R+KNREL IM+ LDH NI++L + Sbjct: 9 YSLGKTLGTGSFGIVCEVFDIESGKRFALKKVLQDPRYKNRELDIMKVLDHVNIIKLVDY 68 Query: 116 FYSSGEKK--------------------------------DEVYLNLVLDYVPETVYRVA 143 FY++G+++ YLN++++YVP+T+++V Sbjct: 69 FYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNVIMEYVPDTLHKVL 128 Query: 144 RHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGS 203 + + R+ +++P+ + +Y+YQLFR++ +IHS GICHRDIKPQNLL++ LKLCDFGS Sbjct: 129 KSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLLVNSKDNTLKLCDFGS 188 Query: 204 AKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGV 263 AK+L+ EP+V+YICSR+YRAPEL+ GAT+YT SID+WS GCV EL+LG+P+F G++ + Sbjct: 189 AKKLIPSEPSVAYICSRFYRAPELMLGATEYTPSIDLWSIGCVFGELILGKPLFSGETSI 248 Query: 264 DQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEY 323 DQLV II+++GTPT+EQ+ MNP+YTE +FP +KA W K+ TP AI L ++L Y Sbjct: 249 DQLVRIIQIMGTPTKEQMIRMNPHYTEVRFPTLKAKDWRKILPEGTPSLAIDLLEQILRY 308 Query: 324 TPTARLTPLEACAHSFFDELRDP-------NVKLPNG--RDTPALFNFTTQELSSNP 371 P R+ P EA AH FFD LR+ N P+G ++ P LFNF+ ELS P Sbjct: 309 EPDLRINPYEAMAHPFFDHLRNSYESEVKNNSNFPHGVNQNIPQLFNFSPYELSIIP 365 >3E3P-A nrPDB Length = 360 Score = 328 bits (840), Expect = 3e-90, Method: Compositional matrix adjust. Identities = 162/345 (46%), Positives = 227/345 (65%), Gaps = 10/345 (2%) Query: 34 GSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRF 93 GS ++ A R + + ++ G G+FG V K +G VAIKKV+QD RF Sbjct: 3 GSMMSLNAAAAADERSRKEMDRFQVERMAGQGTFGTVQLGKEKSTGMSVAIKKVIQDPRF 62 Query: 94 KNRELQIMRKL---DHCNIVRLRYFFYSSGEK-KDEVYLNLVLDYVPETVYRVARHYSRA 149 +NRELQIM+ L H NIV+L+ +FY+ GE+ + ++YLN+V++YVP+T++R R+Y R Sbjct: 63 RNRELQIMQDLAVLHHPNIVQLQSYFYTLGERDRRDIYLNVVMEYVPDTLHRCCRNYYRR 122 Query: 150 KQTLPVIYVKLYMYQLFRSLAYIH--SFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQL 207 + P I +K++++QL RS+ +H S +CHRDIKP N+L++ LKLCDFGSAK+L Sbjct: 123 QVAPPPILIKVFLFQLIRSIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKL 182 Query: 208 VRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLV 267 EPNV+YICSRYYRAPELIFG YT+++D+WS GC+ AE++LG+PIF GD+ QL Sbjct: 183 SPSEPNVAYICSRYYRAPELIFGNQHYTTAVDIWSVGCIFAEMMLGEPIFRGDNSAGQLH 242 Query: 268 EIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRT---PPEAIALCSRLLEYT 324 EI++VLG P+RE +R++NP++T+ K PW+ VF + EA L S LL+Y Sbjct: 243 EIVRVLGCPSREVLRKLNPSHTDVDLYNSKGIPWSNVFSDHSLKDAKEAYDLLSALLQYL 302 Query: 325 PTARLTPLEACAHSFFDELRDPNVKLPNGRDTPA-LFNFTTQELS 368 P R+ P EA H +FDEL DP KLPN +D P LF F E+ Sbjct: 303 PEERMKPYEALCHPYFDELHDPATKLPNNKDLPEDLFRFLPNEIE 347 >4QTB-A nrPDB Length = 380 Score = 181 bits (458), Expect = 7e-46, Method: Compositional matrix adjust. Identities = 115/333 (34%), Positives = 177/333 (53%), Gaps = 42/333 (12%) Query: 43 TPGQGPDRPQEVS------------YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKV--L 88 T G GP P EV YT + IG G++G+V A VAIKK+ Sbjct: 18 TEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPF 77 Query: 89 QDKRFKNR---ELQIMRKLDHCNIVRLRYFFYSSG-EKKDEVYLNLVLDYVPETVYRVAR 144 + + + R E+QI+ + H N++ +R +S E +VY+ V D + +Y++ + Sbjct: 78 EHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYI--VQDLMETDLYKLLK 135 Query: 145 HYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSA 204 Q L ++ ++YQ+ R L YIHS + HRD+KP NLL++ T LK+CDFG A Sbjct: 136 -----SQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINT-TCDLKICDFGLA 189 Query: 205 KQLVRGEPN-------VSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIF 257 + +P Y+ +R+YRAPE++ + YT SID+WS GC+LAE+L +PIF Sbjct: 190 RI---ADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIF 246 Query: 258 PGDSGVDQLVEIIKVLGTPTREQ----IREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEA 313 PG +DQL I+ +LG+P++E I NY + P W K+F P++ +A Sbjct: 247 PGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQ-SLPSKTKVAWAKLF-PKSDSKA 304 Query: 314 IALCSRLLEYTPTARLTPLEACAHSFFDELRDP 346 + L R+L + P R+T EA AH + ++ DP Sbjct: 305 LDLLDRMLTFNPNKRITVEEALAHPYLEQYYDP 337 >3NIZ-A nrPDB Length = 311 Score = 180 bits (457), Expect = 9e-46, Method: Compositional matrix adjust. Identities = 112/306 (36%), Positives = 178/306 (58%), Gaps = 30/306 (9%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDS-GELVAIKKVLQDKRFKN------RELQIMRKLDHCN 108 Y + +G G++GVVY+AK DS G +VA+K++ D + RE+ ++++L H N Sbjct: 23 YQKLEKVGEGTYGVVYKAK--DSQGRIVALKRIRLDAEDEGIPSTAIREISLLKELHHPN 80 Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRS 168 IV L +S E L LV +++ + + +V K L +K+Y+YQL R Sbjct: 81 IVSLIDVIHS------ERCLTLVFEFMEKDLKKVL---DENKTGLQDSQIKIYLYQLLRG 131 Query: 169 LAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSY---ICSRYYRAP 225 +A+ H I HRD+KPQNLL++ D A LKL DFG A+ G P SY + + +YRAP Sbjct: 132 VAHCHQHRILHRDLKPQNLLINSDGA-LKLADFGLARAF--GIPVRSYTHEVVTLWYRAP 188 Query: 226 ELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPT-RE--QIR 282 +++ G+ Y++S+D+WS GC+ AE++ G+P+FPG + DQL +I +LGTP RE Q++ Sbjct: 189 DVLMGSKKYSTSVDIWSIGCIFAEMITGKPLFPGVTDDDQLPKIFSILGTPNPREWPQVQ 248 Query: 283 EMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDE 342 E+ P + + F + PW+ + P E I L S +L + P R++ +A H +F + Sbjct: 249 EL-PLWKQRTFQVFEKKPWSSII-PGFCQEGIDLLSNMLCFDPNKRISARDAMNHPYFKD 306 Query: 343 LRDPNV 348 L DP + Sbjct: 307 L-DPQI 311 >1UA2-A nrPDB Length = 346 Score = 180 bits (456), Expect = 1e-45, Method: Compositional matrix adjust. Identities = 113/300 (37%), Positives = 163/300 (54%), Gaps = 31/300 (10%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN---------RELQIMRKLDH 106 Y +G G F VY+A+ ++ ++VAIKK+ R + RE++++++L H Sbjct: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 Query: 107 CNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLF 166 NI+ L F G K + ++LV D++ + + + S L ++K YM Sbjct: 72 PNIIGLLDAF---GHKSN---ISLVFDFMETDLEVIIKDNSL---VLTPSHIKAYMLMTL 122 Query: 167 RSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSY---ICSRYYR 223 + L Y+H I HRD+KP NLLLD + VLKL DFG AK G PN +Y + +R+YR Sbjct: 123 QGLEYLHQHWILHRDLKPNNLLLD-ENGVLKLADFGLAKSF--GSPNRAYTHQVVTRWYR 179 Query: 224 APELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIRE 283 APEL+FGA Y +D+W+ GC+LAELLL P PGDS +DQL I + LGTPT EQ + Sbjct: 180 APELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPD 239 Query: 284 MN--PNYTEFK-FPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF 340 M P+Y FK FP I H +F + + L L + P AR+T +A +F Sbjct: 240 MCSLPDYVTFKSFPGIPLH---HIFSA-AGDDLLDLIQGLFLFNPCARITATQALKMKYF 295 >4QNY-A nrPDB Length = 354 Score = 179 bits (455), Expect = 1e-45, Method: Compositional matrix adjust. Identities = 115/325 (35%), Positives = 179/325 (55%), Gaps = 27/325 (8%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDS-GELVAIKKVLQD--------KRFKNRELQIMRKLDH 106 Y ++IG GS+GVV +A+ S LVA+K+V ++ KR RE++++ + Sbjct: 22 YLLERIIGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEEVILAKRIL-REIKLLAHFND 80 Query: 107 CNIVRLRYFFYSSG-EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQL 165 NI+ LR E D Y+ V+D + + +V R + Q L +++ ++YQ Sbjct: 81 DNIIGLRNILTPEDPENFDHFYI--VMDIMETDLKQVLR----SGQELTEAHIQFFIYQA 134 Query: 166 FRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLV-RGEPNVSYICSRYYRA 224 R+L IHS G+ HRDI P N+L++ + LK+CDFG AK+ +GE Y+ R+YRA Sbjct: 135 LRALHIIHSAGVIHRDITPANILVNTNCD-LKICDFGLAKEENDQGEYMTDYVTMRWYRA 193 Query: 225 PELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREM 284 PEL+ DY++ IDVW GC+L ELL +P+F G V+QL +I+ V+GTP+ E I + Sbjct: 194 PELVMEDKDYSAQIDVWGIGCILGELLGSRPLFQGKDRVNQLDKIVDVIGTPSEEDINSV 253 Query: 285 NPNYTEFKFPQIKAHPWTKVFRPRTP---PEAIALCSRLLEYTPTARLTPLEACAHSFFD 341 + + K+ + K+H +R R P PEA+ L +L + P R+T L+A H F + Sbjct: 254 GSSAAQ-KYLKKKSHRPQADWRQRYPTASPEALDLLRHMLVFNPKRRITVLQAMRHPFLE 312 Query: 342 ELRDPNVKLPNGRDTPALFNFTTQE 366 +L D + + ALF F E Sbjct: 313 QLHDD----ADDNLSYALFRFDENE 333 >2BPM-A nrPDB Length = 309 Score = 175 bits (443), Expect = 4e-44, Method: Compositional matrix adjust. Identities = 101/303 (33%), Positives = 177/303 (58%), Gaps = 24/303 (7%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN------RELQIMRKLDHCN 108 ++ + IG G++GVVY+A+ +GE+VA+KK+ D + RE+ ++++L+H N Sbjct: 8 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 67 Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRS 168 IV+L ++ + L LV +++ + + + + A +P+ +K Y++QL + Sbjct: 68 IVKLLDVIHTENK------LYLVFEFLHQDLKKFMD--ASALTGIPLPLIKSYLFQLLQG 119 Query: 169 LAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSY---ICSRYYRAP 225 LA+ HS + HRD+KPQNLL++ + A+ KL DFG A+ G P +Y + + +YRAP Sbjct: 120 LAFCHSHRVLHRDLKPQNLLINTEGAI-KLADFGLARAF--GVPVRTYTHEVVTLWYRAP 176 Query: 226 ELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMN 285 E++ G Y++++D+WS GC+ AE++ + +FPGDS +DQL I + LGTP E + Sbjct: 177 EILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPD-EVVWPGV 235 Query: 286 PNYTEFK--FPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDEL 343 + ++K FP+ ++KV P + +L S++L Y P R++ A AH FF ++ Sbjct: 236 TSMPDYKPSFPKWARQDFSKVV-PPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDV 294 Query: 344 RDP 346 P Sbjct: 295 TKP 297 >4BBM-A nrPDB Length = 331 Score = 173 bits (438), Expect = 1e-43, Method: Compositional matrix adjust. Identities = 99/295 (33%), Positives = 158/295 (53%), Gaps = 19/295 (6%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQD------KRFKNRELQIMRKLDHCN 108 Y + ++G GS+G+V + + D+G +VAIKK L+ K+ RE++++++L H N Sbjct: 26 KYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHEN 85 Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRS 168 +V L +KK YL V ++V T+ + L V+ Y++Q+ Sbjct: 86 LVNL----LEVCKKKKRWYL--VFEFVDHTILDDLELFPNG---LDYQVVQKYLFQIING 136 Query: 169 LAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVR-GEPNVSYICSRYYRAPEL 227 + + HS I HRDIKP+N+L+ + V+KLCDFG A+ L GE + +R+YRAPEL Sbjct: 137 IGFCHSHNIIHRDIKPENILV-SQSGVVKLCDFGFARTLAAPGEVYDDEVATRWYRAPEL 195 Query: 228 IFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGT--PTREQIREMN 285 + G Y ++DVW+ GC++ E+ +G+P+FPGDS +DQL I+ LG P +++ N Sbjct: 196 LVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKN 255 Query: 286 PNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF 340 P + + P+IK + P+ I L + L P R E H FF Sbjct: 256 PVFAGVRLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFF 310 >4IC8-A nrPDB Length = 442 Score = 173 bits (438), Expect = 2e-43, Method: Compositional matrix adjust. Identities = 105/310 (33%), Positives = 169/310 (54%), Gaps = 26/310 (8%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKK------VLQDKRFKNRELQIMRKLDHCN 108 Y + IGNG++GVV A+ +G+ VAIKK V+ + + REL+I++ H N Sbjct: 56 EYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDN 115 Query: 109 IVRLRYFFYSS---GEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQL 165 I+ ++ + GE K VY+ VLD + ++++ + Q L + +V+ ++YQL Sbjct: 116 IIAIKDILRPTVPYGEFKS-VYV--VLDLMESDLHQIIH----SSQPLTLEHVRYFLYQL 168 Query: 166 FRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPN-----VSYICSR 220 R L Y+HS + HRD+KP NLL++ + LK+ DFG A+ L Y+ +R Sbjct: 169 LRGLKYMHSAQVIHRDLKPSNLLVN-ENCELKIGDFGMARGLCTSPAEHQYFMTEYVATR 227 Query: 221 YYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQ 280 +YRAPEL+ +YT +ID+WS GC+ E+L + +FPG + V QL I+ VLGTP+ Sbjct: 228 WYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAV 287 Query: 281 IREMNPNYTEF---KFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAH 337 I+ + P + PW V+ P +A++L R+L + P+AR++ A H Sbjct: 288 IQAVGAERVRAYIQSLPPRQPVPWETVY-PGADRQALSLLGRMLRFEPSARISAAAALRH 346 Query: 338 SFFDELRDPN 347 F + DP+ Sbjct: 347 PFLAKYHDPD 356 >6DTL-A nrPDB Length = 364 Score = 172 bits (435), Expect = 3e-43, Method: Compositional matrix adjust. Identities = 108/321 (33%), Positives = 175/321 (54%), Gaps = 27/321 (8%) Query: 62 IGNGSFGVVYQAKLCDSGELVAIKKVLQ------DKRFKNRELQIMRKLDHCNIVRLRYF 115 IG G++G+V A ++ E VAIKK+ D + RE++++R +DH NIV +R Sbjct: 38 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 97 Query: 116 FYSSGEKK-DEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHS 174 ++VY+ + + ++++ R + Q L + + ++YQ+ R L YIHS Sbjct: 98 IPPPLRNAFNDVYI--AYELMDTDLHQIIR----SNQALSEEHCQYFLYQILRGLKYIHS 151 Query: 175 FGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDY 234 + HRD+KP NLLL+ + LK+CDFG A+ + Y+ +R+YRAPEL+ ++DY Sbjct: 152 ANVLHRDLKPSNLLLNANCD-LKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDY 210 Query: 235 TSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEF--K 292 T++IDVWS GC+ EL+ +P+FPG V QL +++++GTP+ E++ +N N + + Sbjct: 211 TAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQ 270 Query: 293 FPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRD----PNV 348 P T F P P AI L ++L + P R+T L+A AH + + L D P Sbjct: 271 LPPYPRQSITDKF-PTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISDEPEC 329 Query: 349 KLPNGRDTPALFNFTTQELSS 369 +P F+F LS Sbjct: 330 TIPFN------FDFENHALSE 344 >4MYG-A nrPDB Length = 372 Score = 172 bits (435), Expect = 4e-43, Method: Compositional matrix adjust. Identities = 101/304 (33%), Positives = 164/304 (53%), Gaps = 23/304 (7%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKV---LQDKRFKNR---ELQIMRKLDHCN 108 +Y +G+G++G V A SGE VAIKK+ Q + F R EL +++ + H N Sbjct: 44 TYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHEN 103 Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRV-ARHYSRAKQTLPVIYVKLYMYQLFR 167 ++ L F + ++ LV+ ++ + ++ +S K ++ +YQ+ + Sbjct: 104 VIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEK-------IQYLVYQMLK 156 Query: 168 SLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPEL 227 L YIHS G+ HRD+KP NL ++ D LK+ DFG A+ Y+ +R+YRAPE+ Sbjct: 157 GLKYIHSAGVVHRDLKPGNLAVNEDCE-LKILDFGLARH--ADAEMTGYVVTRWYRAPEV 213 Query: 228 IFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMN-- 285 I Y ++D+WS GC++AE+L G+ +F G +DQL +I+KV G P E ++++N Sbjct: 214 ILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDK 273 Query: 286 --PNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDEL 343 +Y + PQ +T++F PR P+A L ++LE RLT +A H FF+ Sbjct: 274 AAKSYIQ-SLPQTPRKDFTQLF-PRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPF 331 Query: 344 RDPN 347 RDP Sbjct: 332 RDPE 335 >4ZSG-A nrPDB Length = 347 Score = 171 bits (432), Expect = 7e-43, Method: Compositional matrix adjust. Identities = 106/311 (34%), Positives = 171/311 (54%), Gaps = 28/311 (9%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKK------VLQDKRFKNRELQIMRKLDHCN 108 Y + IGNG++GVV A+ +G+ VAIKK V+ + + REL+I++ H N Sbjct: 8 EYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDN 67 Query: 109 IVRLRYFFYSS---GEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQL 165 I+ ++ + GE K VY+ VLD + ++++ + Q L + +V+ ++YQL Sbjct: 68 IIAIKDILRPTVPYGEFKS-VYV--VLDLMESDLHQIIH----SSQPLTLEHVRYFLYQL 120 Query: 166 FRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPN-----VSYICSR 220 R L Y+HS + HRD+KP NLL++ + LK+ DFG A+ L Y+ +R Sbjct: 121 LRGLKYMHSAQVIHRDLKPSNLLVN-ENCELKIGDFGMARGLCTSPAEHQYFMTEYVATR 179 Query: 221 YYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQ 280 +YRAPEL+ +YT +ID+WS GC+ E+L + +FPG + V QL I+ VLGTP+ Sbjct: 180 WYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAV 239 Query: 281 IREMNPN----YTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACA 336 I+ + Y + P + PW V+ P +A++L R+L + P+AR++ A Sbjct: 240 IQAVGAERVRAYIQ-SLPPRQPVPWETVY-PGADRQALSLLGRMLRFEPSARISAAAALR 297 Query: 337 HSFFDELRDPN 347 H F + DP+ Sbjct: 298 HPFLAKYHDPD 308 >5NGU-A nrPDB Length = 381 Score = 170 bits (430), Expect = 1e-42, Method: Compositional matrix adjust. Identities = 102/308 (33%), Positives = 169/308 (54%), Gaps = 28/308 (9%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKV--LQDKRFKNR---ELQIMRKLDHCNIV 110 YT+ IG G++G+V A + VAIKK+ + + + R E++I+ + H NI+ Sbjct: 44 YTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENII 103 Query: 111 RLRYFFYS-SGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 169 + + + E+ +VY+ V D + +Y++ + Q L ++ ++YQ+ R L Sbjct: 104 GINDIIRAPTIEQMKDVYI--VQDLMETDLYKLLK-----TQHLSNDHICYFLYQILRGL 156 Query: 170 AYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPN-------VSYICSRYY 222 YIHS + HRD+KP NLLL+ T LK+CDFG A+ +P+ Y+ +R+Y Sbjct: 157 KYIHSANVLHRDLKPSNLLLNT-TCDLKICDFGLARV---ADPDHDHTGFLTEYVATRWY 212 Query: 223 RAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQ-- 280 RAPE++ + YT SID+WS GC+LAE+L +PIFPG +DQL I+ +LG+P++E Sbjct: 213 RAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLN 272 Query: 281 -IREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSF 339 I + P PW ++F P +A+ L ++L + P R+ +A AH + Sbjct: 273 CIINLKARNYLLSLPHKNKVPWNRLF-PNADSKALDLLDKMLTFNPHKRIEVEQALAHPY 331 Query: 340 FDELRDPN 347 ++ DP+ Sbjct: 332 LEQYYDPS 339 >4AGU-A nrPDB Length = 311 Score = 167 bits (422), Expect = 1e-41, Method: Compositional matrix adjust. Identities = 109/315 (34%), Positives = 165/315 (52%), Gaps = 24/315 (7%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQD------KRFKNRELQIMRKLDHCN 108 Y IG GS+GVV++ + D+G++VAIKK L+ K+ RE++++++L H N Sbjct: 4 KYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKHPN 63 Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRS 168 +V L F + + L+LV +Y TV Y R +P VK +Q ++ Sbjct: 64 LVNLLEVF------RRKRRLHLVFEYCDHTVLHELDRYQRG---VPEHLVKSITWQTLQA 114 Query: 169 LAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSY---ICSRYYRAP 225 + + H HRD+KP+N+L+ +V+KLCDFG A+ L P+ Y + +R+YR+P Sbjct: 115 VNFCHKHNCIHRDVKPENILI-TKHSVIKLCDFGFARLLTG--PSDYYDDEVATRWYRSP 171 Query: 226 ELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLG--TPTREQIRE 283 EL+ G T Y +DVW+ GCV AELL G P++PG S VDQL I K LG P +Q+ Sbjct: 172 ELLVGDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFS 231 Query: 284 MNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDEL 343 N ++ K P + ++ P A+ L L PT RLT + H +F+ + Sbjct: 232 TNQYFSGVKIPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTERLTCEQLLHHPYFENI 291 Query: 344 RDPNVKLPNGRDTPA 358 R+ L D PA Sbjct: 292 REIE-DLAKEHDKPA 305 >3GC9-A nrPDB Length = 370 Score = 167 bits (422), Expect = 1e-41, Method: Compositional matrix adjust. Identities = 101/297 (34%), Positives = 161/297 (54%), Gaps = 22/297 (7%) Query: 62 IGNGSFGVVYQAKLCDSGELVAIKKV------LQDKRFKNRELQIMRKLDHCNIVRLRYF 115 +G+G++G V A + VA+KK+ L R REL++++ L H N++ L Sbjct: 36 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDV 95 Query: 116 FY--SSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIH 173 F +S E EVYL V + + + + Q L +V+ +YQL R L YIH Sbjct: 96 FTPATSIEDFSEVYL--VTTLMGADLNNIVK-----SQALSDEHVQFLVYQLLRGLKYIH 148 Query: 174 SFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATD 233 S GI HRD+KP N+ ++ D+ L++ DFG A+Q E Y+ +R+YRAPE++ Sbjct: 149 SAGIIHRDLKPSNVAVNEDSE-LRILDFGLARQ--ADEEMTGYVATRWYRAPEIMLNWMH 205 Query: 234 YTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEF-- 291 Y ++D+WS GC++AELL G+ +FPG +DQL I++V+GTP+ E + +++ + Sbjct: 206 YNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYI 265 Query: 292 -KFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPN 347 P + + +FR P AI L R+L R++ EA AH++F + DP Sbjct: 266 QSLPPMPQKDLSSIFRGANPL-AIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPE 321 >5Z33-A nrPDB Length = 425 Score = 166 bits (419), Expect = 3e-41, Method: Compositional matrix adjust. Identities = 114/322 (35%), Positives = 166/322 (51%), Gaps = 27/322 (8%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKV---LQDKRFKNRELQIMRKLDHC----N 108 YT TK +G G++G+V A + E VAIKKV K R L+ ++ L H N Sbjct: 33 YTVTKELGQGAYGIVCAAVNNQTSEGVAIKKVTNVFSKKILAKRALREIKLLQHFRGHRN 92 Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRS 168 I L + +E YL E + R+ Q L + + ++YQ+ Sbjct: 93 ITCLYDMDIPRPDNFNETYL------YEELMECDLAAIIRSGQPLTDAHFQSFIYQILCG 146 Query: 169 LAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQL-VRGEPNVSY----ICSRYYR 223 L YIHS + HRD+KP NLL++ D LK+CDFG A+ V E N Y + +R+YR Sbjct: 147 LKYIHSANVLHRDLKPGNLLVNADCE-LKICDFGLARGFSVDPEENAGYMTEYVATRWYR 205 Query: 224 APELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQI-R 282 APE++ YT +IDVWS GC+LAELL G+P F G VDQL +I+ +LGTP E + R Sbjct: 206 APEIMLSFQSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQILHILGTPNEETLSR 265 Query: 283 EMNPNYTEF--KFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF 340 +P E+ P + P+ +F P P+A+ L R+L + P++R++ +A H + Sbjct: 266 IGSPRAQEYVRNLPFMAKKPFPTLF-PNANPDALDLLDRMLAFDPSSRISVEQALEHPYL 324 Query: 341 DELRDPNVKLPNGRDTPALFNF 362 D + + D P FNF Sbjct: 325 HIWHDAS----DEPDCPTTFNF 342 >3OZ6-A nrPDB Length = 388 Score = 166 bits (419), Expect = 3e-41, Method: Compositional matrix adjust. Identities = 105/346 (30%), Positives = 171/346 (49%), Gaps = 57/346 (16%) Query: 49 DRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ------DKRFKNRELQIMR 102 DR Y K +G G++G+V+++ +GE+VA+KK+ D + RE+ I+ Sbjct: 4 DRHVLRKYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQNSTDAQRTFREIMILT 63 Query: 103 KLD-HCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLY 161 +L H NIV L + ++ +VYL V DY+ ++ V R L ++ + Sbjct: 64 ELSGHENIVNLLNVLRADNDR--DVYL--VFDYMETDLHAVIR-----ANILEPVHKQYV 114 Query: 162 MYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLV---RGEPNV---- 214 +YQL + + Y+HS G+ HRD+KP N+LL+ + V K+ DFG ++ V R N+ Sbjct: 115 VYQLIKVIKYLHSGGLLHRDMKPSNILLNAECHV-KVADFGLSRSFVNIRRVTNNIPLSI 173 Query: 215 ---------------SYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPG 259 Y+ +R+YRAPE++ G+T YT ID+WS GC+L E+L G+PIFPG Sbjct: 174 NENTENFDDDQPILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGKPIFPG 233 Query: 260 DSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------PWTKVFR 306 S ++QL II V+ P+ E + + + + +K W + Sbjct: 234 SSTMNQLERIIGVIDFPSNEDVESIQSPFAKTMIESLKEKVEIRQSNKRDIFTKWKNLLL 293 Query: 307 PRTP-----PEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPN 347 P EA+ L +LL++ P R++ +A H F +PN Sbjct: 294 KINPKADCNEEALDLLDKLLQFNPNKRISANDALKHPFVSIFHNPN 339 >4BGQ-A nrPDB Length = 304 Score = 165 bits (418), Expect = 3e-41, Method: Compositional matrix adjust. Identities = 109/297 (36%), Positives = 160/297 (53%), Gaps = 26/297 (8%) Query: 61 VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN------RELQIMRKLDHCNIVRLRY 114 V+G G++GVV + + ++ E+VAIKK + + REL+++R L NIV L+ Sbjct: 19 VVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVELKE 78 Query: 115 FFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHS 174 F G+ L LV +YV + + + +P VK Y+YQL +++ + H Sbjct: 79 AFRRRGK------LYLVFEYVEKNMLELLEEMPNG---VPPEKVKSYIYQLIKAIHWCHK 129 Query: 175 FGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSY---ICSRYYRAPELIFGA 231 I HRDIKP+NLL+ + VLKLCDFG A+ L G N +Y + +R+YR+PEL+ GA Sbjct: 130 NDIVHRDIKPENLLISHND-VLKLCDFGFARNLSEGN-NANYDEEVATRWYRSPELLLGA 187 Query: 232 TDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREM--NPNYT 289 Y S+D+WS GC+L EL GQP+FPG+S +DQL I KVLG EQ++ NP + Sbjct: 188 P-YGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFH 246 Query: 290 EFKFPQIKAHPWTKVFRPRTPPEAIA--LCSRLLEYTPTARLTPLEACAHSFFDELR 344 +FP + HP + R ++ L LL+ P R + H F R Sbjct: 247 GLRFPAVN-HPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQR 302 >1CM8-A nrPDB Length = 367 Score = 164 bits (416), Expect = 5e-41, Method: Compositional matrix adjust. Identities = 97/300 (32%), Positives = 161/300 (53%), Gaps = 20/300 (6%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKV---LQDKRFKNR---ELQIMRKLDHCNI 109 Y D + +G+G++G V A +G VAIKK+ Q + F R EL++++ + H N+ Sbjct: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 Query: 110 VRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 169 + L F D LV+ ++ + ++ +H + L ++ +YQ+ + L Sbjct: 87 IGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKH-----EKLGEDRIQFLVYQMLKGL 141 Query: 170 AYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIF 229 YIH+ GI HRD+KP NL ++ D LK+ DFG A+Q Y+ +R+YRAPE+I Sbjct: 142 RYIHAAGIIHRDLKPGNLAVNEDCE-LKILDFGLARQA--DSEMTGYVVTRWYRAPEVIL 198 Query: 230 GATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMN---- 285 YT ++D+WS GC++AE++ G+ +F G +DQL EI+KV GTP E ++ + Sbjct: 199 NWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEA 258 Query: 286 PNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRD 345 NY + P+++ + + P A+ L ++L R+T EA AH +F+ L D Sbjct: 259 KNYMK-GLPELEKKDFASIL-TNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHD 316 >2F9G-A nrPDB Length = 353 Score = 162 bits (411), Expect = 2e-40, Method: Compositional matrix adjust. Identities = 106/323 (32%), Positives = 171/323 (52%), Gaps = 30/323 (9%) Query: 61 VIGNGSFGVVYQAKLCDSGELVAIKKVLQ-DKRF----KNRELQIMRKLDHCNIVRLRYF 115 ++G G++GVV A +GE+VAIKK+ DK RE++I++ H NI+ + Sbjct: 18 LLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITI--- 74 Query: 116 FYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSF 175 ++ + + N Y+ + + + H + Q L +++ ++YQ R++ +H Sbjct: 75 ---FNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHGS 131 Query: 176 GICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRG-----EPN------VSYICSRYYRA 224 + HRD+KP NLL++ + LK+CDFG A+ + EP Y+ +R+YRA Sbjct: 132 NVIHRDLKPSNLLINSNCD-LKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRA 190 Query: 225 PELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQ-IRE 283 PE++ + Y+ ++DVWS GC+LAEL L +PIFPG QL+ I ++GTP + +R Sbjct: 191 PEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRC 250 Query: 284 M-NPNYTEF--KFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF 340 + +P E+ P A P K+F PR P+ I L R+L + P R+T EA H + Sbjct: 251 IESPRAREYIKSLPMYPAAPLEKMF-PRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYL 309 Query: 341 DELRDPNVKLPNGRDT-PALFNF 362 DPN + P G P+ F F Sbjct: 310 QTYHDPNDE-PEGEPIPPSFFEF 331 >1V0B-A nrPDB Length = 288 Score = 162 bits (409), Expect = 3e-40, Method: Compositional matrix adjust. Identities = 99/301 (32%), Positives = 163/301 (54%), Gaps = 32/301 (10%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN------RELQIMRKLDHCNI 109 Y + IG G++GVVY+A+ + GE A+KK+ +K + RE+ I+++L H NI Sbjct: 4 YHGLEKIGEGTYGVVYKAQ-NNYGETFALKKIRLEKEDEGIPSTTIREISILKELKHSNI 62 Query: 110 VRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 169 V+L ++ L LV +++ + + ++ + L + K ++ QL + Sbjct: 63 VKLYDVIHTKKR------LVLVFEHLDQDLKKLL---DVCEGGLESVTAKSFLLQLLNGI 113 Query: 170 AYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSY---ICSRYYRAPE 226 AY H + HRD+KPQNLL++ + LK+ DFG A+ G P Y + + +YRAP+ Sbjct: 114 AYCHDRRVLHRDLKPQNLLINREGE-LKIADFGLARAF--GIPVRKYTHEVVTLWYRAPD 170 Query: 227 LIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNP 286 ++ G+ Y+++ID+WS GC+ AE++ G P+FPG S DQL+ I ++LGTP + P Sbjct: 171 VLMGSKKYSTTIDIWSVGCIFAEMVNGAPLFPGVSEADQLMRIFRILGTPNSKNW----P 226 Query: 287 NYTEF-----KFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFD 341 N TE F + PW + F I L S++L+ P R+T +A H++F Sbjct: 227 NVTELPKYDPNFTVYEPLPW-ESFLKGLDESGIDLLSKMLKLDPNQRITAKQALEHAYFK 285 Query: 342 E 342 E Sbjct: 286 E 286 >5G6V-A nrPDB Length = 324 Score = 161 bits (407), Expect = 5e-40, Method: Compositional matrix adjust. Identities = 101/333 (30%), Positives = 173/333 (51%), Gaps = 34/333 (10%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN---------RELQIMRKLD 105 +Y +G G++ VY+ K + LVA+K++ R ++ RE+ +++ L Sbjct: 3 TYIKLDKLGEGTYATVYKGKSKLTDNLVALKEI----RLEHEEGAPCTAIREVSLLKDLK 58 Query: 106 HCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQL 165 H NIV L ++ E L LV +Y+ + + ++ + + VKL+++QL Sbjct: 59 HANIVTLHDIIHT------EKSLTLVFEYLDKDL---KQYLDDCGNIINMHNVKLFLFQL 109 Query: 166 FRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSY---ICSRYY 222 R LAY H + HRD+KPQNLL++ + LKL DFG A+ + P +Y + + +Y Sbjct: 110 LRGLAYCHRQKVLHRDLKPQNLLIN-ERGELKLADFGLAR--AKSIPTKTYDNEVVTLWY 166 Query: 223 RAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIR 282 R P+++ G+TDY++ ID+W GC+ E+ G+P+FPG + +QL I ++LGTPT E Sbjct: 167 RPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWP 226 Query: 283 EM--NPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF 340 + N + + +P+ +A PR + L ++LL++ R++ +A H FF Sbjct: 227 GILSNEEFKTYNYPKYRAEALLS-HAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFF 285 Query: 341 DELRDPNVKLPNGRDTPALFNFTTQELSSNPPL 373 L + KLP DT ++F +L L Sbjct: 286 LSLGERIHKLP---DTTSIFALKEIQLQKEASL 315 >4AU8-A nrPDB Length = 296 Score = 160 bits (406), Expect = 7e-40, Method: Compositional matrix adjust. Identities = 106/303 (34%), Positives = 165/303 (54%), Gaps = 26/303 (8%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN------RELQIMRKLDHCNI 109 Y + IG G++G V++AK ++ E+VA+K+V D + RE+ ++++L H NI Sbjct: 8 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 67 Query: 110 VRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 169 VRL +S +KK L LV ++ + + +++ L VK +++QL + L Sbjct: 68 VRLHDVLHS--DKK----LTLVFEFCDQDL---KKYFDSCNGDLDPEIVKSFLFQLLKGL 118 Query: 170 AYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSY---ICSRYYRAPE 226 + HS + HRD+KPQNLL++ + LKL DFG A+ G P Y + + +YR P+ Sbjct: 119 GFCHSRNVLHRDLKPQNLLINRN-GELKLADFGLARAF--GIPVRCYSAEVVTLWYRPPD 175 Query: 227 LIFGATDYTSSIDVWSAGCVLAELL-LGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMN 285 ++FGA Y++SID+WSAGC+ AEL G+P+FPG+ DQL I ++LGTPT EQ M Sbjct: 176 VLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMT 235 Query: 286 --PNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDEL 343 P+Y +P A P+ L LL+ P R++ EA H +F + Sbjct: 236 KLPDYK--PYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDF 293 Query: 344 RDP 346 P Sbjct: 294 CPP 296 >4EWQ-A nrPDB Length = 383 Score = 158 bits (399), Expect = 5e-39, Method: Compositional matrix adjust. Identities = 102/318 (32%), Positives = 171/318 (53%), Gaps = 31/318 (9%) Query: 43 TPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKK-------VLQDKRFKN 95 T + P+R Q +S +G+G++G V A +G VA+KK ++ KR Sbjct: 39 TIWEVPERYQNLS-----PVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR-TY 92 Query: 96 RELQIMRKLDHCNIVRLRYFFY--SSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTL 153 REL++++ + H N++ L F S E+ ++VYL V + + + + Q L Sbjct: 93 RELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYL--VTHLMGADLNNIVK-----CQKL 145 Query: 154 PVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPN 213 +V+ +YQ+ R L YIHS I HRD+KP NL ++ D LK+ DFG A+ + Sbjct: 146 TDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCE-LKILDFGLARH--TDDEM 202 Query: 214 VSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVL 273 Y+ +R+YRAPE++ Y ++D+WS GC++AELL G+ +FPG +DQL I++++ Sbjct: 203 TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLV 262 Query: 274 GTPTREQIREMNP----NYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARL 329 GTP E +++++ NY + Q+ + VF P A+ L ++L R+ Sbjct: 263 GTPGAELLKKISSESARNYIQ-SLTQMPKMNFANVFIGANPL-AVDLLEKMLVLDSDKRI 320 Query: 330 TPLEACAHSFFDELRDPN 347 T +A AH++F + DP+ Sbjct: 321 TAAQALAHAYFAQYHDPD 338 >3OHT-A nrPDB Length = 389 Score = 155 bits (393), Expect = 3e-38, Method: Compositional matrix adjust. Identities = 103/318 (32%), Positives = 167/318 (52%), Gaps = 31/318 (9%) Query: 43 TPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKK-------VLQDKRFKN 95 T + P+R Q +S +G+G++G V + SG +A+KK ++ KR Sbjct: 45 TIWEVPERYQTLS-----PVGSGAYGSVCSSYDVKSGLKIAVKKLSRPFQSIIHAKR-TY 98 Query: 96 RELQIMRKLDHCNIVRLRYFFY--SSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTL 153 REL++++ + H N++ L F +S E+ ++VYL V + + + + Q L Sbjct: 99 RELRLLKHMKHENVIGLLDVFTPATSLEEFNDVYL--VTHLMGADLNNIVK-----CQKL 151 Query: 154 PVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPN 213 +V+ +YQ+ R L YIHS I HRD+KP NL ++ D LK+ DFG A+ + Sbjct: 152 TDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCE-LKILDFGLARH--TDDEM 208 Query: 214 VSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVL 273 Y+ +R+YRAPE++ Y ++D+WS GC++AELL G+ +FPG ++QL +I+++ Sbjct: 209 TGYVATRWYRAPEIMLNWMHYNMTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLT 268 Query: 274 GTPTREQIREM----NPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARL 329 GTP I M NY PQ+ + VF P A+ L ++L R+ Sbjct: 269 GTPPASVISRMPSHEARNYIN-SLPQMPKRNFADVFIGANPL-AVDLLEKMLVLDTDKRI 326 Query: 330 TPLEACAHSFFDELRDPN 347 T EA AH +F + DP+ Sbjct: 327 TASEALAHPYFSQYHDPD 344 >2I6L-A nrPDB Length = 320 Score = 154 bits (390), Expect = 5e-38, Method: Compositional matrix adjust. Identities = 97/302 (32%), Positives = 165/302 (54%), Gaps = 22/302 (7%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVL----QDKRFKNRELQIMRKLDHCNIVR 111 Y D K +G G G+V+ A D + VAIKK++ Q + RE++I+R+LDH NIV+ Sbjct: 13 YMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHALREIKIIRRLDHDNIVK 72 Query: 112 LRYFFYSSGEK-KDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVI--YVKLYMYQLFRS 168 + SG + D+V L+ V + + + P++ + +L+MYQL R Sbjct: 73 VFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLLRG 132 Query: 169 LAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSY-------ICSRY 221 L YIHS + HRD+KP NL ++ + VLK+ DFG A+ + +P+ S+ + +++ Sbjct: 133 LKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIM---DPHYSHKGHLSEGLVTKW 189 Query: 222 YRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQL---VEIIKVLGTPTR 278 YR+P L+ +YT +ID+W+AGC+ AE+L G+ +F G ++Q+ +E I V+ R Sbjct: 190 YRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDR 249 Query: 279 EQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHS 338 +++ + P Y + P T++ P EA+ ++L ++P RLT EA +H Sbjct: 250 QELLSVIPVYIRNDMTE-PHKPLTQLL-PGISREAVDFLEQILTFSPMDRLTAEEALSHP 307 Query: 339 FF 340 + Sbjct: 308 YM 309 >6GU6-A nrPDB Length = 302 Score = 152 bits (385), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 96/300 (32%), Positives = 162/300 (54%), Gaps = 25/300 (8%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN------RELQIMRKLDHCNI 109 YT + IG G++GVVY+ + +G++VA+KK+ + + RE+ ++++L H NI Sbjct: 9 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNI 68 Query: 110 VRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 169 V L+ L L+ +++ + + Q + VK Y+YQ+ + + Sbjct: 69 VSLQDVLMQDSR------LYLIFEFLSMDLKKYLDSIPPG-QYMDSSLVKSYLYQILQGI 121 Query: 170 AYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSY---ICSRYYRAPE 226 + HS + HRD+KPQNLL+D D +KL DFG A+ G P Y + + +YR+PE Sbjct: 122 VFCHSRRVLHRDLKPQNLLID-DKGTIKLADFGLARAF--GIPIRVYTHEVVTLWYRSPE 178 Query: 227 LIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNP 286 ++ G+ Y++ +D+WS G + AEL +P+F GDS +DQL I + LGTP E E+ Sbjct: 179 VLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVE- 237 Query: 287 NYTEFK--FPQIKAHPWTKVFRPRTPPE-AIALCSRLLEYTPTARLTPLEACAHSFFDEL 343 + ++K FP+ K P + + E + L S++L Y P R++ A H +F++L Sbjct: 238 SLQDYKNTFPKWK--PGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDL 295 >4KRC-A nrPDB Length = 317 Score = 151 bits (381), Expect = 6e-37, Method: Compositional matrix adjust. Identities = 99/300 (33%), Positives = 160/300 (53%), Gaps = 32/300 (10%) Query: 62 IGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN-----RELQIMRKLDHCNIVRLRYFF 116 +GNG++ VY+ +G VA+K+V D RE+ +M++L H NIVRL Sbjct: 13 LGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYDVI 72 Query: 117 YSSGEKKDEVYLNLVLDYVPETV--YRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHS 174 ++ E L LV +++ + Y +R + L + VK + +QL + LA+ H Sbjct: 73 HT------ENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHE 126 Query: 175 FGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSY---ICSRYYRAPELIFGA 231 I HRD+KPQNLL++ LKL DFG A+ G P ++ + + +YRAP+++ G+ Sbjct: 127 NKILHRDLKPQNLLIN-KRGQLKLGDFGLARAF--GIPVNTFSSEVVTLWYRAPDVLMGS 183 Query: 232 TDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEF 291 Y++SID+WS GC+LAE++ G+P+FPG + +QL I ++GTP + P+ T+ Sbjct: 184 RTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPN----ESLWPSVTKL 239 Query: 292 -KF-PQIKAHP---WTKVFRPRTPP----EAIALCSRLLEYTPTARLTPLEACAHSFFDE 342 K+ P I+ P +V +P T + LL+ P RL+ +A H +F E Sbjct: 240 PKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAE 299 >3GC0-A nrPDB Length = 329 Score = 146 bits (369), Expect = 1e-35, Method: Compositional matrix adjust. Identities = 90/294 (30%), Positives = 154/294 (52%), Gaps = 28/294 (9%) Query: 62 IGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN------RELQIMRKLDHCNIVRLRYF 115 +G G++G VY+A + E VAIK++ + + RE+ ++++L H NI+ L+ Sbjct: 42 LGEGTYGEVYKAIDTVTNETVAIKRIRLEHEEEGVPGTAIREVSLLKELQHRNIIELKSV 101 Query: 116 FYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSF 175 + + L+L+ +Y + + Y + + +K ++YQL + + HS Sbjct: 102 IHHNHR------LHLIFEYAENDL----KKYMDKNPDVSMRVIKSFLYQLINGVNFCHSR 151 Query: 176 GICHRDIKPQNLLLD----PDTAVLKLCDFGSAKQLVRGEPNVSY---ICSRYYRAPELI 228 HRD+KPQNLLL +T VLK+ DFG A+ G P + I + +YR PE++ Sbjct: 152 RCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAF--GIPIRQFTHEIITLWYRPPEIL 209 Query: 229 FGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMN--P 286 G+ Y++S+D+WS C+ AE+L+ P+FPGDS +DQL +I +VLG P + P Sbjct: 210 LGSRHYSTSVDIWSIACIWAEMLMKTPLFPGDSEIDQLFKIFEVLGLPDDTTWPGVTALP 269 Query: 287 NYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF 340 ++ + FP+ + +V E + L + +LE P R++ A H +F Sbjct: 270 DWKQ-SFPKFRGKTLKRVLGALLDDEGLDLLTAMLEMDPVKRISAKNALEHPYF 322 >3PG1-A nrPDB Length = 362 Score = 143 bits (361), Expect = 1e-34, Method: Compositional matrix adjust. Identities = 96/310 (30%), Positives = 154/310 (49%), Gaps = 26/310 (8%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ---DKRFKN------------RELQI 100 YT + I +GS+G V A + G VAIK+V D R N RE+++ Sbjct: 24 YTVQRFISSGSYGAVC-AGVDSEGIPVAIKRVFNTVSDGRTVNILSDSFLCKRVLREIRL 82 Query: 101 MRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKL 160 + H NI+ LR F E L LV + + + +V H R + +++ Sbjct: 83 LNHFHHPNILGLRDIFVHFEEPAMH-KLYLVTELMRTDLAQVI-HDQRI--VISPQHIQY 138 Query: 161 YMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSR 220 +MY + L +H G+ HRD+ P N+LL D + +CDF A++ Y+ R Sbjct: 139 FMYHILLGLHVLHEAGVVHRDLHPGNILL-ADNNDITICDFNLAREDTADANKTHYVTHR 197 Query: 221 YYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQ 280 +YRAPEL+ +T +D+WSAGCV+AE+ + +F G + +QL +I++V+GTP E Sbjct: 198 WYRAPELVMQFKGFTKLVDMWSAGCVMAEMFNRKALFRGSTFYNQLNKIVEVVGTPKIED 257 Query: 281 IREMNP----NYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACA 336 + + +Y + A WT V P P A+ L +++LE+ P R++ +A Sbjct: 258 VVMFSSPSARDYLRNSLSNVPARAWTAVV-PTADPVALDLIAKMLEFNPQRRISTEQALR 316 Query: 337 HSFFDELRDP 346 H +F+ L DP Sbjct: 317 HPYFESLFDP 326 >3RP9-A nrPDB Length = 458 Score = 143 bits (361), Expect = 1e-34, Method: Compositional matrix adjust. Identities = 118/375 (31%), Positives = 173/375 (46%), Gaps = 86/375 (22%) Query: 46 QGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ------DKRFKNRELQ 99 Q PDR Y +IG GS+G V +A +VAIKK+L+ D + RE+ Sbjct: 50 QIPDR-----YEIRHLIGTGSYGHVCEAYDKLEKRVVAIKKILRVFEDLIDCKRILREIA 104 Query: 100 IMRKLDHCNIVR-LRYFFYSSGEKKDEVYLNL-VLDYVPETVYRVARHYSRAKQTLPVIY 157 I+ +L+H ++V+ L EK DE+Y+ L + D + ++R + L ++ Sbjct: 105 ILNRLNHDHVVKVLDIVIPKDVEKFDELYVVLEIADSDFKKLFRTPVY-------LTELH 157 Query: 158 VKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVS-- 215 +K +Y L + Y+HS GI HRD+KP N L++ D +V K+CDFG A+ + E S Sbjct: 158 IKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQDCSV-KVCDFGLARTVDYPENGNSQL 216 Query: 216 --------------------------YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAE 249 ++ +R+YRAPELI +YT +IDVWS GC+ AE Sbjct: 217 PISPREDDMNLVTFPHTKNLKRQLTGHVVTRWYRAPELILLQENYTEAIDVWSIGCIFAE 276 Query: 250 LLL-----------GQPIFPGDS--------------------GVDQLVEIIKVLGTPTR 278 LL P+FPG S DQL I +LGTP+ Sbjct: 277 LLNMIKENVAYHADRGPLFPGSSCFPLSPDQKAGNDFKFHTRGNRDQLNVIFNILGTPSE 336 Query: 279 EQI----REMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEA 334 E I +E Y FP+ + + F P + +AI L R+L + P R+T E Sbjct: 337 EDIEALEKEDAKRYIRI-FPKREGTDLAERF-PASSADAIHLLKRMLVFNPNKRITINEC 394 Query: 335 CAHSFFDELRDPNVK 349 AH FF E+R V+ Sbjct: 395 LAHPFFKEVRIAEVE 409 >3ZDU-A nrPDB Length = 325 Score = 142 bits (357), Expect = 4e-34, Method: Compositional matrix adjust. Identities = 82/287 (28%), Positives = 148/287 (51%), Gaps = 18/287 (6%) Query: 62 IGNGSFGVVYQAKLCDSGELVAIKKVLQD-----KRFKNRELQIMRKLDHCNIVRLRYFF 116 +G GS+G V + K ++G++VAIK + + RE++ +++ H N+V L F Sbjct: 11 VGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQFHHENLVNLIEVF 70 Query: 117 YSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFG 176 + + ++LV +++ TV +HY L ++ Y++Q+ R++ Y+HS Sbjct: 71 ------RQKKKIHLVFEFIDHTVLDELQHYCHG---LESKRLRKYLFQILRAIDYLHSNN 121 Query: 177 ICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVR-GEPNVSYICSRYYRAPELIFGATDYT 235 I HRDIKP+N+L+ + + KLCDFG A+ L G+ + +R+YRAPEL+ T Y Sbjct: 122 IIHRDIKPENILVS-QSGITKLCDFGFARTLAAPGDIYDDEVATRWYRAPELVLKDTSYG 180 Query: 236 SSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLG--TPTREQIREMNPNYTEFKF 293 +D+W+ GC++ E+ G P P S +D L +I+ +G +P + I +P + Sbjct: 181 KPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVVL 240 Query: 294 PQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF 340 PQ++ + P+ + L+ P R++ + H +F Sbjct: 241 PQVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYF 287 >6O6Q-A nrPDB Length = 335 Score = 137 bits (346), Expect = 6e-33, Method: Compositional matrix adjust. Identities = 97/307 (31%), Positives = 153/307 (49%), Gaps = 27/307 (8%) Query: 51 PQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFK-NRELQIMRKL-DHCN 108 PQE +Y + +G G + V+ + E V IK + KR K RE+ I++ L D N Sbjct: 39 PQE-NYEILRKLGRGKYSEVFLGIDLEKREKVVIKVLKPVKRKKIKREISILKNLVDGPN 97 Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRS 168 I+ + K L+ +++ +R T ++ YMY+L ++ Sbjct: 98 IIAMLDVVREPQSKTP----GLIFEHINNIDFR------SLYPTFTDYDIRFYMYELLKA 147 Query: 169 LAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRG-EPNVSYICSRYYRAPEL 227 L Y HS GI HRD+KP N+++D D +L+L D+G A+ G E NV + SRY++ PEL Sbjct: 148 LDYSHSMGIMHRDVKPHNVMIDHDKKLLRLIDWGLAEYYHPGTEYNVR-VASRYFKGPEL 206 Query: 228 IFGATDYTSSIDVWSAGCVLAELL-LGQPIFPGDSGVDQLVEIIKVLGTPTREQIRE--- 283 + Y S+D+WS GC+LA ++ + +P F G S DQLV+I++VLG+ ++ E Sbjct: 207 LVDYRLYDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQLVQIVRVLGSKNFKKYLEKYN 266 Query: 284 --MNPNYTEFKFPQIKAHPWTKVF----RPRTPPEAIALCSRLLEYTPTARLTPLEACAH 337 + Y + + W + + E + L RLL Y RLT EA H Sbjct: 267 ISLGEEYEDIGY--YNKRQWVRFMNENNKDLVSQEFLDLIDRLLRYDHQERLTAKEAMKH 324 Query: 338 SFFDELR 344 ++FD +R Sbjct: 325 AYFDPIR 331 >5AWM-A nrPDB Length = 394 Score = 137 bits (345), Expect = 1e-32, Method: Compositional matrix adjust. Identities = 95/315 (30%), Positives = 163/315 (51%), Gaps = 38/315 (12%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN--------RELQIMRKLDHC 107 Y + + IG+G+ G+V A + + VAIKK+ + F+N RE ++M+ ++H Sbjct: 46 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKL--SRPFQNVTHAKRAYREFKLMKLVNHK 103 Query: 108 NIVRLRYFF--YSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQL 165 NI+ L F + E+ +VYL V++ + + +V + L + +YQ+ Sbjct: 104 NIIGLLNAFTPQRNLEEFQDVYL--VMELMDANLCQVI------QMDLDHDRMSYLLYQM 155 Query: 166 FRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAP 225 + ++HS GI HRD+KP N+++ D LK+ DFG A+ Y+ +RYYRAP Sbjct: 156 LCGIKHLHSAGIIHRDLKPSNIVVKAD-CTLKILDFGLARTAGTTFMMTPYVVTRYYRAP 214 Query: 226 ELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMN 285 E+I G YT ++D+WS GC++ E++ G +FPG +DQ +II+ LGTP+ ++ + Sbjct: 215 EVILGM-GYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQ 273 Query: 286 P---NYTEFKFPQIKAHPWTKVF------------RPRTPPEAIALCSRLLEYTPTARLT 330 P NY E + P+ + + ++F R +A L S++L P R++ Sbjct: 274 PTVRNYVENR-PRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRIS 332 Query: 331 PLEACAHSFFDELRD 345 EA H + + D Sbjct: 333 VDEALKHEYINVWYD 347 >4O2Z-A nrPDB Length = 377 Score = 136 bits (342), Expect = 2e-32, Method: Compositional matrix adjust. Identities = 98/335 (29%), Positives = 164/335 (48%), Gaps = 52/335 (15%) Query: 36 KVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKV------LQ 89 KV V +P + P + YT K++G G++G+ D+GE V+IKK ++ Sbjct: 32 KVYNVSGSPFEVPSK-----YTLLKILGMGAYGIACSCLDGDTGEKVSIKKCRDVFRDVE 86 Query: 90 DKRFKNRELQIMRKLDHCNIVRLRYFF------YSSGEKKDEVYLNLVLDYVPETVYRVA 143 D + RE+ +MR H N++ + Y S E +VY+ L V V Sbjct: 87 DGKRVLREIDMMRFFHHENLLNVVNILPPLKREYHSFE---DVYVVTPLMDVDMNVVL-- 141 Query: 144 RHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGS 203 R++Q L +++ ++YQ+ R L Y+HS + HRD+KP NL+ + + LK+ DFG Sbjct: 142 ----RSRQVLEESHMQYFVYQILRGLKYLHSANVAHRDLKPANLVTNI-SCELKIIDFGL 196 Query: 204 AKQL-VRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSG 262 ++ + V Y+ +R+YR PEL+ T+Y++++D+WS GC+ AE+ +P+FPG + Sbjct: 197 SRSVDVPYSELTDYVITRWYRPPELLLENTNYSTAVDIWSVGCIFAEMYNRKPVFPGRNT 256 Query: 263 VDQLVEIIKVLGTP------TREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPP----- 311 +DQL I + +G P RE + ++N P + P+ P Sbjct: 257 MDQLRMIAQHIGKPPASIVEHREALEKLN------------ELPDGSLNIPKLVPGLAGN 304 Query: 312 -EAIALCSRLLEYTPTARLTPLEACAHSFFDELRD 345 E I S++ P+ R T + AH + L D Sbjct: 305 TEGIDFLSKMWTLDPSKRPTAADMLAHPYLAHLHD 339 >4NST-A nrPDB Length = 351 Score = 136 bits (342), Expect = 2e-32, Method: Compositional matrix adjust. Identities = 100/327 (30%), Positives = 158/327 (48%), Gaps = 40/327 (12%) Query: 61 VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN------RELQIMRKLDHCNIVRLRY 114 +IG G++G VY+AK D+GELVA+KKV D + RE++I+R+L H ++V ++ Sbjct: 20 IIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKE 79 Query: 115 FFYSSGE----KKDEVYLNLVLDYVPETVYRVAR----HYSRAKQTLPVIYVKLYMYQLF 166 + KKD+ LV +Y+ + + H+S ++K +M QL Sbjct: 80 IVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSED-------HIKSFMKQLM 132 Query: 167 RSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGE--PNVSYICSRYYRA 224 L Y H HRDIK N+LL+ ++ +KL DFG A+ E P + + + +YR Sbjct: 133 EGLEYCHKKNFLHRDIKCSNILLN-NSGQIKLADFGLARLYNSEESRPYTNKVITLWYRP 191 Query: 225 PELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREM 284 PEL+ G YT +IDVWS GC+L EL +PIF + + QL I ++ G+P + Sbjct: 192 PELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPC----PAV 247 Query: 285 NPNYTEFKFPQIKAHPWTKVFRPR-------TPPEAIALCSRLLEYTPTARLTPLEACAH 337 P+ K P K +R R P A+ L +L P+ R T + Sbjct: 248 WPDV--IKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQS 305 Query: 338 SFFDELRDPNV---KLPNGRDTPALFN 361 F ++ + LP+ +D L++ Sbjct: 306 DFLKDVELSKMAPPDLPHWQDCHELWS 332 >2PVN-A nrPDB Length = 352 Score = 135 bits (341), Expect = 3e-32, Method: Compositional matrix adjust. Identities = 80/231 (34%), Positives = 122/231 (52%), Gaps = 27/231 (11%) Query: 129 NLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLL 188 +L+ +YV T ++V TL ++ Y+Y+L ++L Y HS GI HRD+KP N++ Sbjct: 125 SLIFEYVNNTDFKVLY------PTLTDYDIRYYIYELLKALDYCHSQGIMHRDVKPHNVM 178 Query: 189 LDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLA 248 +D + L+L D+G A+ G+ + SRY++ PEL+ DY S+D+WS GC+ A Sbjct: 179 IDHELRKLRLIDWGLAEFYHPGKEYNVRVASRYFKGPELLVDLQDYDYSLDMWSLGCMFA 238 Query: 249 ELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKF---PQIKA------ 298 ++ +P F G DQLV+I KVLGT +N +++ PQ++A Sbjct: 239 GMIFRKEPFFYGHDNHDQLVKIAKVLGTDG------LNAYLNKYRIELDPQLEALVGRHS 292 Query: 299 -HPWTKVF----RPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELR 344 PW K + PEAI +LL Y RLT LEA H +F ++R Sbjct: 293 RKPWLKFMNADNQHLVSPEAIDFLDKLLRYDHQERLTALEAMTHPYFQQVR 343 >2XS0-A nrPDB Length = 386 Score = 134 bits (336), Expect = 9e-32, Method: Compositional matrix adjust. Identities = 97/317 (30%), Positives = 162/317 (51%), Gaps = 39/317 (12%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN--------RELQIMRKLDHC 107 Y + K IG+G+ G+V A VAIKK+ + F+N REL +M+ ++H Sbjct: 28 YQNLKPIGSGAQGIVCAAYDAILERNVAIKKL--SRPFQNQTHAKRAYRELVLMKCVNHK 85 Query: 108 NIVRLRYFF--YSSGEKKDEVYLNL-VLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQ 164 NI+ L F S E+ +VY+ + ++D V ++ + R L YQ Sbjct: 86 NIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHERMSYLL---------YQ 136 Query: 165 LFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRA 224 + + ++HS GI HRD+KP N+++ D LK+ DFG A+ V ++ +RYYRA Sbjct: 137 MLCGIKHLHSAGIIHRDLKPSNIVVKSD-CTLKILDFGLARTAGTSFMMVPFVVTRYYRA 195 Query: 225 PELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREM 284 PE+I G Y ++D+WS GC++ E++ G +FPG +DQ ++I+ LGTP E ++++ Sbjct: 196 PEVILG-MGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKL 254 Query: 285 NP---NYTEFKFPQIKAHPWTKVFRPRTPP-----------EAIALCSRLLEYTPTARLT 330 P Y E + P+ + + K+F P +A L S++L + R++ Sbjct: 255 QPTVRTYVENR-PKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRIS 313 Query: 331 PLEACAHSFFDELRDPN 347 EA H + + DP+ Sbjct: 314 VDEALQHPYINVWYDPS 330 >1JNK-A nrPDB Length = 423 Score = 132 bits (333), Expect = 2e-31, Method: Compositional matrix adjust. Identities = 97/316 (30%), Positives = 160/316 (50%), Gaps = 39/316 (12%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN--------RELQIMRKLDHC 107 Y + K IG+G+ G+V A VAIKK+ + F+N REL +M+ ++H Sbjct: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKL--SRPFQNQTHAKRAYRELVLMKCVNHK 121 Query: 108 NIVRLRYFF--YSSGEKKDEVYLNL-VLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQ 164 NI+ L F + E+ +VYL + ++D V ++ + R L YQ Sbjct: 122 NIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLL---------YQ 172 Query: 165 LFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRA 224 + + ++HS GI HRD+KP N+++ D LK+ DFG A+ Y+ +RYYRA Sbjct: 173 MLCGIKHLHSAGIIHRDLKPSNIVVKSD-CTLKILDFGLARTAGTSFMMTPYVVTRYYRA 231 Query: 225 PELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREM 284 PE+I G Y ++D+WS GC++ E++ + +FPG +DQ ++I+ LGTP E ++++ Sbjct: 232 PEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKL 290 Query: 285 NP---NYTEFKFPQIKAHPWTKVFRPRTPP-----------EAIALCSRLLEYTPTARLT 330 P NY E + P+ + K+F P +A L S++L P R++ Sbjct: 291 QPTVRNYVENR-PKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS 349 Query: 331 PLEACAHSFFDELRDP 346 +A H + + DP Sbjct: 350 VDDALQHPYINVWYDP 365 >5EFQ-A nrPDB Length = 347 Score = 132 bits (332), Expect = 3e-31, Method: Compositional matrix adjust. Identities = 97/333 (29%), Positives = 158/333 (47%), Gaps = 52/333 (15%) Query: 61 VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN------RELQIMRKLDHCNIVRLRY 114 +IG G++G VY+A+ D+GE+VA+KKV D + RE++I+R+L H +I+ ++ Sbjct: 18 IIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKE 77 Query: 115 FFYSSGE----KKDEVYLNLVLDYVPETVYRVAR----HYSRAKQTLPVIYVKLYMYQLF 166 + KKD+ LV +Y+ + + H++ ++K +M QL Sbjct: 78 IVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNEN-------HIKSFMRQLM 130 Query: 167 RSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGE--PNVSYICSRYYRA 224 L Y H HRDIK N+LL+ + +KL DFG A+ E P + + + +YR Sbjct: 131 EGLDYCHKKNFLHRDIKCSNILLN-NRGQIKLADFGLARLYSSEESRPYTNKVITLWYRP 189 Query: 225 PELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREM 284 PEL+ G YT +IDVWS GC+L EL +PIF + + QL I ++ G+P Sbjct: 190 PELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPC------- 242 Query: 285 NPNYTEFKFPQIKAHPWTKVFRPR-------------TPPEAIALCSRLLEYTPTARLTP 331 P +P + P+ +P+ P A+ L +L P+ R T Sbjct: 243 -PAV----WPDVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTA 297 Query: 332 LEACAHSFFDEL---RDPNVKLPNGRDTPALFN 361 +A F ++ + P LP +D L++ Sbjct: 298 EQALQCEFLRDVEPSKMPPPDLPLWQDCHELWS 330 >4MD7-E nrPDB Length = 391 Score = 130 bits (327), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 92/290 (31%), Positives = 143/290 (49%), Gaps = 34/290 (11%) Query: 130 LVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLL 189 LV ++V T ++ + QTL ++ YMY++ ++L Y HS GI HRD+KP N+++ Sbjct: 111 LVFEHVNNTDFK------QLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMI 164 Query: 190 DPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAE 249 D + L+L D+G A+ G+ + SRY++ PEL+ Y S+D+WS GC+LA Sbjct: 165 DHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLAS 224 Query: 250 LLL-GQPIFPGDSGVDQLVEIIKVLGTP-----TREQIREMNPNYTEFKFPQIKAHPWTK 303 ++ +P F G DQLV I KVLGT + E++P + + + W + Sbjct: 225 MIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKR-WER 283 Query: 304 VFRPRT----PPEAIALCSRLLEYTPTARLTPLEACAHSFF-----DELRDPNVKLPNGR 354 PEA+ +LL Y +RLT EA H +F D+ R + +P G Sbjct: 284 FVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGS 343 Query: 355 DTPALFNFTTQELSSNP---PLATILIPPHARIQAAASP-----PANATA 396 + + N + +SS P PL + P + AAA+P PA A A Sbjct: 344 EPVSSANMMSG-ISSVPEPEPLGPLAGEP---VIAAANPLGMPVPAAAGA 389 >3E7O-A nrPDB Length = 360 Score = 130 bits (327), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 98/316 (31%), Positives = 159/316 (50%), Gaps = 39/316 (12%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN--------RELQIMRKLDHC 107 Y K IG+G+ G+V A G VA+KK+ + F+N REL +++ ++H Sbjct: 24 YQQLKPIGSGAQGIVCAAFDTVLGINVAVKKL--SRPFQNQTHAKRAYRELVLLKCVNHK 81 Query: 108 NIVRLRYFF--YSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQL 165 NI+ L F + E+ +VYL V++ + + +V H + + + +YQ+ Sbjct: 82 NIISLLNVFTPQKTLEEFQDVYL--VMELMDANLCQVI-HMELDHERMSYL-----LYQM 133 Query: 166 FRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAP 225 + ++HS GI HRD+KP N+++ D LK+ DFG A+ Y+ +RYYRAP Sbjct: 134 LCGIKHLHSAGIIHRDLKPSNIVVKSD-CTLKILDFGLARTASTNFMMTPYVVTRYYRAP 192 Query: 226 ELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMN 285 E+I G Y ++D+WS GC++ EL+ G IF G +DQ ++I+ LGTP+ E + + Sbjct: 193 EVILG-MGYKENVDIWSVGCIMGELVKGSVIFQGTDHIDQWNKVIEQLGTPSAEFMAALQ 251 Query: 286 P---NYTEFK--FPQIKAHP----WTKVFRPRTPPEAIA------LCSRLLEYTPTARLT 330 P NY E + +P I W +F + + I L S++L P R++ Sbjct: 252 PTVRNYVENRPAYPGIAFEELFPDW--IFPSESERDKIKTSQARDLLSKMLVIDPDKRIS 309 Query: 331 PLEACAHSFFDELRDP 346 EA H + DP Sbjct: 310 VDEALRHPYITVWYDP 325 >6HMD-A nrPDB Length = 365 Score = 129 bits (324), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 74/221 (33%), Positives = 113/221 (51%), Gaps = 17/221 (7%) Query: 130 LVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLL 189 LV +Y+ T ++ + Q L ++ YMY+L ++L Y HS GI HRD+KP N+++ Sbjct: 127 LVFEYINNTDFK------QLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMI 180 Query: 190 DPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAE 249 D L+L D+G A+ + + SRY++ PEL+ Y S+D+WS GC+LA Sbjct: 181 DHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLAS 240 Query: 250 LLL-GQPIFPGDSGVDQLVEIIKVLGTPT-----REQIREMNPNYTEFKFPQIKAHPWTK 303 ++ +P F G DQLV I KVLGT ++ +++P++ + Q W Sbjct: 241 MIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDI-LGQHSRKRWEN 299 Query: 304 VF----RPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF 340 R PEA+ L +LL Y RLT EA H +F Sbjct: 300 FIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 340 >3N9X-A nrPDB Length = 432 Score = 129 bits (323), Expect = 3e-30, Method: Compositional matrix adjust. Identities = 107/351 (30%), Positives = 160/351 (45%), Gaps = 69/351 (19%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKV------LQDKRFKNRELQIMRKLDHCN 108 +Y +IG GS+G VY A ++ + VAIKKV L D + RE+ I+ +L Sbjct: 27 NYIIKHLIGRGSYGYVYLAYDKNTEKNVAIKKVNRMFEDLIDCKRILREITILNRLKSDY 86 Query: 109 IVRLRYFFYSSGEKK-DEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFR 167 I+RL K DE+Y+ V E + + L ++K +Y L Sbjct: 87 IIRLYDLIIPDDLLKFDELYI------VLEIADSDLKKLFKTPIFLTEEHIKTILYNLLL 140 Query: 168 SLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQL-------------VRGEPN- 213 +IH GI HRD+KP N LL+ D +V K+CDFG A+ + EP Sbjct: 141 GENFIHESGIIHRDLKPANCLLNQDCSV-KVCDFGLARTINSEKDTNIVNDLEENEEPGP 199 Query: 214 ---------VSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELL-LGQ--------- 254 S++ +R+YRAPELI +YT SID+WS GC+ AELL + Q Sbjct: 200 HNKNLKKQLTSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAELLNMLQSHINDPTNR 259 Query: 255 -PIFPGD-----------------SGVDQLVEIIKVLGTPTREQIREMN-PNYTEF--KF 293 P+FPG S DQL I ++GTPT + ++ +N P ++ F Sbjct: 260 FPLFPGSSCFPLSPDRNSKKVHEKSNRDQLNIIFNIIGTPTEDDLKNINKPEVIKYIKLF 319 Query: 294 PQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELR 344 P K + + P + I L +L++ P R+T +A H + ++R Sbjct: 320 PHRKPINLKQKY-PSISDDGINLLESMLKFNPNKRITIDQALDHPYLKDVR 369 >3FI2-A nrPDB Length = 353 Score = 128 bits (322), Expect = 4e-30, Method: Compositional matrix adjust. Identities = 95/311 (30%), Positives = 158/311 (50%), Gaps = 39/311 (12%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN--------RELQIMRKLDHC 107 Y + K IG+G+ G+V A VAIKK+ + F+N REL +M+ ++H Sbjct: 26 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKL--SRPFQNQTHAKRAYRELVLMKCVNHK 83 Query: 108 NIVRLRYFF--YSSGEKKDEVYLNL-VLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQ 164 NI+ L F + E+ +VYL + ++D V ++ + R L YQ Sbjct: 84 NIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLL---------YQ 134 Query: 165 LFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRA 224 + + ++HS GI HRD+KP N+++ D LK+ DFG A+ Y+ +RYYRA Sbjct: 135 MLCGIKHLHSAGIIHRDLKPSNIVVKSD-CTLKILDFGLARTAGTSFMMTPYVVTRYYRA 193 Query: 225 PELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREM 284 PE+I G Y ++D+WS GC++ E++ + +FPG +DQ ++I+ LGTP E ++++ Sbjct: 194 PEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKL 252 Query: 285 NP---NYTEFKFPQIKAHPWTKVFRPRTPP-----------EAIALCSRLLEYTPTARLT 330 P NY E + P+ + K+F P +A L S++L P R++ Sbjct: 253 QPTVRNYVENR-PKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS 311 Query: 331 PLEACAHSFFD 341 +A H + + Sbjct: 312 VDDALQHPYIN 322 >6EII-A nrPDB Length = 352 Score = 128 bits (322), Expect = 4e-30, Method: Compositional matrix adjust. Identities = 74/222 (33%), Positives = 115/222 (51%), Gaps = 19/222 (8%) Query: 130 LVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLL 189 LV ++V T ++ + QTL ++ YMY++ ++L Y HS GI HRD+KP N+++ Sbjct: 134 LVFEHVNNTDFK------QLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMI 187 Query: 190 DPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAE 249 D + L+L D+G A+ G+ + SRY++ PEL+ Y S+D+WS GC+LA Sbjct: 188 DHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLAS 247 Query: 250 LLL-GQPIFPGDSGVDQLVEIIKVLGTP------TREQIREMNPNYTEFKFPQIKAHPWT 302 ++ +P F G DQLV I KVLGT + I E++P + + + W Sbjct: 248 MIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNI-ELDPRFNDI-LGRHSRKRWE 305 Query: 303 KVFRPRT----PPEAIALCSRLLEYTPTARLTPLEACAHSFF 340 + PEA+ +LL Y +RLT EA H +F Sbjct: 306 RFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 347 >1G3N-A nrPDB Length = 326 Score = 127 bits (320), Expect = 6e-30, Method: Compositional matrix adjust. Identities = 91/294 (30%), Positives = 151/294 (51%), Gaps = 21/294 (7%) Query: 62 IGNGSFGVVYQAK-LCDSGELVAIKKVLQDKRFKN------RELQIMRKLD---HCNIVR 111 IG G++G V++A+ L + G VA+K+V + RE+ ++R L+ H N+VR Sbjct: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVR 78 Query: 112 LRYFFYSSGEKKD-EVYLNLVLDYVPETVYRVARHYSRAKQ-TLPVIYVKLYMYQLFRSL 169 L F + + D E L LV ++V + + + + + +P +K M+QL R L Sbjct: 79 L--FDVCTVSRTDRETKLTLVFEHVDQDL---TTYLDKVPEPGVPTETIKDMMFQLLRGL 133 Query: 170 AYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIF 229 ++HS + HRD+KPQN+L+ + +KL DFG A+ S + + +YRAPE++ Sbjct: 134 DFLHSHRVVHRDLKPQNILV-TSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLL 192 Query: 230 GATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYT 289 ++ Y + +D+WS GC+ AE+ +P+F G S VDQL +I+ V+G P E + Sbjct: 193 QSS-YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPR-DVALP 250 Query: 290 EFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDEL 343 F A P K F L + L + P R++ A +H +F +L Sbjct: 251 RQAFHSKSAQPIEK-FVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDL 303 >4LFI-A nrPDB Length = 374 Score = 124 bits (312), Expect = 6e-29, Method: Compositional matrix adjust. Identities = 78/226 (34%), Positives = 116/226 (51%), Gaps = 17/226 (7%) Query: 130 LVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLL 189 LV +YV +R+ Y + L + ++ YM++L ++L Y HS GI HRD+KP N+++ Sbjct: 152 LVFEYVDNVDFRIL--YPK----LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMI 205 Query: 190 DPDTAVLKLCDFGSAK-QLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLA 248 D L+L D+G A+ V E NV + SR+++ PEL+ Y S+D+WS G +LA Sbjct: 206 DHKNKKLRLIDWGLAEFYHVNMEYNVR-VASRFFKGPELLVDYRMYDYSLDLWSFGTMLA 264 Query: 249 ELLLG-QPIFPGDSGVDQLVEIIKVLGTPTREQI---REMNPNYTEFKFPQIKAHPWTKV 304 ++ +P F G S DQLV+I+KVLGT E+ E+ + Q PW + Sbjct: 265 SMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRF 324 Query: 305 FRPRTP-----PEAIALCSRLLEYTPTARLTPLEACAHSFFDELRD 345 E I L LL Y RLT EA H +F +R+ Sbjct: 325 INDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIRE 370 >5XVU-A nrPDB Length = 332 Score = 124 bits (311), Expect = 7e-29, Method: Compositional matrix adjust. Identities = 66/198 (33%), Positives = 106/198 (53%), Gaps = 11/198 (5%) Query: 158 VKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYI 217 ++ Y+YQ+ ++L Y HS GI HRD+KP N+++D + ++L +G A+ G+ + Sbjct: 127 IRYYIYQILKALDYCHSQGIMHRDVKPHNIMIDHENRQIRLISWGLAEFYHPGQEYNVRV 186 Query: 218 CSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTP 276 SRYY+ PEL+ Y S+D+WS GC+LA ++ +P F G DQLV+I KVLGT Sbjct: 187 ASRYYKGPELLIDLQLYDYSLDIWSLGCMLAGMIFKKEPFFCGHDNYDQLVKIAKVLGTE 246 Query: 277 T-----REQIREMNPNYTEFKFPQIKAHPWTKVFRPRT----PPEAIALCSRLLEYTPTA 327 ++ ++ P+Y + + PW+ E I L ++L Y Sbjct: 247 DLHAYLKKYNIKLKPHYLNI-LGEYERKPWSHFLTQSNIDIAKDEVIDLIDKMLIYDHAK 305 Query: 328 RLTPLEACAHSFFDELRD 345 R+ P EA H +F E+R+ Sbjct: 306 RIAPKEAMEHPYFREVRE 323 >3MIA-A nrPDB Length = 351 Score = 123 bits (309), Expect = 1e-28, Method: Compositional matrix adjust. Identities = 99/308 (32%), Positives = 148/308 (48%), Gaps = 27/308 (8%) Query: 53 EVS-YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN------RELQIMRKLD 105 EVS Y IG G+FG V++A+ +G+ VA+KKVL + + RE++I++ L Sbjct: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLK 74 Query: 106 HCNIVRLRYFFYSSGEK----KDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLY 161 H N+V L + K +YL V D+ + +A S + +K Sbjct: 75 HENVVNLIEICRTKASPYNRCKGSIYL--VFDFCE---HDLAGLLSNVLVKFTLSEIKRV 129 Query: 162 MYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLV---RGEPN--VSY 216 M L L YIH I HRD+K N+L+ D VLKL DFG A+ +PN + Sbjct: 130 MQMLLNGLYYIHRNKILHRDMKAANVLITRD-GVLKLADFGLARAFSLAKNSQPNRYTNR 188 Query: 217 ICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTP 276 + + +YR PEL+ G DY ID+W AGC++AE+ PI G++ QL I ++ G+ Sbjct: 189 VVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSI 248 Query: 277 TREQIREMNPNYTEF-KFPQIKAHPWTKVFRPRT---PPEAIALCSRLLEYTPTARLTPL 332 T E ++ NY + K +K R + P A+ L +LL P R+ Sbjct: 249 TPEVWPNVD-NYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSD 307 Query: 333 EACAHSFF 340 +A H FF Sbjct: 308 DALNHDFF 315 >2W96-B nrPDB Length = 306 Score = 123 bits (308), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 92/300 (30%), Positives = 144/300 (48%), Gaps = 28/300 (9%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN----------RELQIMRKLD 105 Y IG G++G VY+A+ SG VA+K V R N RE+ ++R+L+ Sbjct: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSV----RVPNGEEGLPISTVREVALLRRLE 61 Query: 106 ---HCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHY--SRAKQTLPVIYVKL 160 H N+VRL +S + E+ + LV ++V + + R Y LP +K Sbjct: 62 AFEHPNVVRLMDVCATSRTDR-EIKVTLVFEHVDQDL----RTYLDKAPPPGLPAETIKD 116 Query: 161 YMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSR 220 M Q R L ++H+ I HRD+KP+N+L+ V KL DFG A+ + + Sbjct: 117 LMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTV-KLADFGLARIYSYQMALDPVVVTL 175 Query: 221 YYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQ 280 +YRAPE++ +T Y + +D+WS GC+ AE+ +P+F G+S DQL +I ++G P E Sbjct: 176 WYRAPEVLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPP-ED 233 Query: 281 IREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF 340 + + FP P V P L +L + P R++ A HS+ Sbjct: 234 DWPRDVSLPRGAFPPRGPRPVQSVV-PEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL 292 >5Y86-A nrPDB Length = 588 Score = 122 bits (307), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 94/328 (28%), Positives = 155/328 (47%), Gaps = 53/328 (16%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHC-------- 107 Y K+IG GSFG V + + VA+K V +KRF + + +R L+H Sbjct: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268 Query: 108 -NIVR-LRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQL 165 N++ L F + + ++ + + + +Y + + Q V V+ + + Sbjct: 269 MNVIHMLESFTFRN-------HVCMAFELLSIDLYELIK--KNKFQGFSVQLVRKFAQSI 319 Query: 166 FRSLAYIHSFGICHRDIKPQNLLLDPDT-AVLKLCDFGSAKQLVRGEPNVSYICSRYYRA 224 +SL +H I H D+KP+N+LL + K+ DFGS+ + +YI SR+YRA Sbjct: 320 LQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSS--CFEYQKLYTYIQSRFYRA 377 Query: 225 PELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREM 284 PE+I G+ Y++ ID+WS GC+LAELL GQP+FPG+ DQL ++++LG P + + + Sbjct: 378 PEIILGSR-YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQS 436 Query: 285 N-----------PNY----TEFKFPQIKAHPWTKVFRPRTPPEA---------------I 314 P Y T+ + ++ + R PP + I Sbjct: 437 KRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFI 496 Query: 315 ALCSRLLEYTPTARLTPLEACAHSFFDE 342 R L + P+ARLTP +A H + + Sbjct: 497 EFLKRCLHWDPSARLTPAQALRHPWISK 524 >3NIE-A nrPDB Length = 429 Score = 122 bits (306), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 108/379 (28%), Positives = 165/379 (43%), Gaps = 87/379 (22%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKV------LQDKRFKNRELQIMRKLDHCN 108 +Y +IG GS+G VY A ++ + VAIKKV L D + RE+ I+ +L Sbjct: 29 NYEIKHLIGRGSYGYVYLAYDKNANKNVAIKKVNRMFEDLIDCKRILREITILNRLKSDY 88 Query: 109 IVRLRYFFYSSGEKK-DEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFR 167 I+RL K DE+Y+ V E + + L +VK +Y L Sbjct: 89 IIRLHDLIIPEDLLKFDELYI------VLEIADSDLKKLFKTPIFLTEQHVKTILYNLLL 142 Query: 168 SLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNV------------- 214 +IH GI HRD+KP N LL+ D +V K+CDFG A+ + + ++ Sbjct: 143 GEKFIHESGIIHRDLKPANCLLNQDCSV-KICDFGLART-INSDKDIHIVNDLEEKEENE 200 Query: 215 --------------SYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQ------ 254 S++ +R+YRAPELI +YT+SID+WS GC+ AELL Sbjct: 201 EPGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTGCIFAELLNMMKSHINN 260 Query: 255 -----PIFPGD-----------------SGVDQLVEIIKVLGTPTREQIREMNPN----Y 288 P+FPG S DQL I V+GTP E ++ + Y Sbjct: 261 PTNRFPLFPGSSCFPLSPDHNSKKVHEKSNRDQLNIIFNVIGTPPEEDLKCITKQEVIKY 320 Query: 289 TEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNV 348 + FP +K + E I L +L + R+T +A +H + ++R N+ Sbjct: 321 IKL-FPTRDGIDLSKKY-SSISKEGIDLLESMLRFNAQKRITIDKALSHPYLKDVRKENL 378 Query: 349 KLPNGRDTPALFNFTTQEL 367 + NF+T+++ Sbjct: 379 E-----------NFSTEKI 386 >4MVF-A nrPDB Length = 506 Score = 122 bits (306), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 91/298 (30%), Positives = 146/298 (48%), Gaps = 44/298 (14%) Query: 53 EVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN-----RELQIMRKLDHC 107 E Y + +G G++G VY+ + +L AIK+ +D R KN +E++IM+KLDH Sbjct: 56 EDKYIIDEKLGQGTYGCVYKGIDKVTNQLYAIKEEKKD-RLKNINRFFQEIEIMKKLDHP 114 Query: 108 NIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFR 167 NIV+L Y + E + +YL + L E + + S ++ I M Q+F Sbjct: 115 NIVKL----YETYENDNYIYLIMELCSGRELFDSIIENGSFTEKNAATI-----MKQIFS 165 Query: 168 SLAYIHSFGICHRDIKPQNLLLDPDT--AVLKLCDFGSAKQLVRGEPNVSYICSRYYRAP 225 ++ Y+HS I HRD+KP+N L + ++LK+ DFG +K L GE + + YY AP Sbjct: 166 AIFYLHSLNIVHRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFTTTKAGTPYYVAP 225 Query: 226 ELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMN 285 +++ G Y D+WS+G ++ LL G P F GD+ + L ++ K Sbjct: 226 QVLDGK--YDKKCDIWSSGVIMYTLLCGYPPFYGDTDNEVLKKVKK-------------- 269 Query: 286 PNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDEL 343 EF F + + W + +A L ++LL Y P R T EA H + ++ Sbjct: 270 ---GEFCFYE---NDWGSI-----SSDAKNLITKLLTYNPNERCTIEEALNHPWITQM 316 >2WO6-A nrPDB Length = 382 Score = 121 bits (304), Expect = 5e-28, Method: Compositional matrix adjust. Identities = 104/340 (30%), Positives = 165/340 (48%), Gaps = 64/340 (18%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN------RELQIMRKLD---H 106 Y +IG GSFG V +A E VAIK + K F N R L++M K D Sbjct: 56 YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK 115 Query: 107 CNIVRL-RYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQL 165 IV L R+F + + +L LV + + +Y + R+ + +L + + + Q+ Sbjct: 116 YYIVHLKRHFMFRN-------HLCLVFEMLSYNLYDLLRNTNFRGVSLNL--TRKFAQQM 166 Query: 166 FRSLAYIHS--FGICHRDIKPQNLLL-DPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYY 222 +L ++ + I H D+KP+N+LL +P + +K+ DFGS+ QL G+ YI SR+Y Sbjct: 167 CTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQL--GQRIYQYIQSRFY 224 Query: 223 RAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIR 282 R+PE++ G Y +ID+WS GC+L E+ G+P+F G + VDQ+ +I++VLG P I Sbjct: 225 RSPEVLLGMP-YDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPP-AHIL 282 Query: 283 EMNPNYTEFKFPQIKAHPWT--------KVFRP-------------------RTPPEA-- 313 + P +F F ++ W + ++P R E+ Sbjct: 283 DQAPKARKF-FEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGH 341 Query: 314 -IA-------LCSRLLEYTPTARLTPLEACAHSFFDELRD 345 +A L R+L+Y P R+ P A HSFF + D Sbjct: 342 TVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTAD 381 >5ZTN-A nrPDB Length = 429 Score = 121 bits (303), Expect = 6e-28, Method: Compositional matrix adjust. Identities = 97/338 (28%), Positives = 159/338 (47%), Gaps = 48/338 (14%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN------RELQIMRKLDHCNI 109 Y KVIG GSFG V +A + VA+K V +KRF R L+ +RK D N Sbjct: 99 YEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNT 158 Query: 110 VRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 169 + + + + + ++ + + + +Y + + +LP+ V+ + + + + L Sbjct: 159 MNVIHMLENFTFRN---HICMTFELLSMNLYELIKKNKFQGFSLPL--VRKFAHSILQCL 213 Query: 170 AYIHSFGICHRDIKPQNLLLDPDT-AVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELI 228 +H I H D+KP+N+LL + +K+ DFGS+ + +YI SR+YRAPE+I Sbjct: 214 DALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSS--CYEHQRVYTYIQSRFYRAPEVI 271 Query: 229 FGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQI--REMNP 286 GA Y ID+WS GC+LAELL G P+ PG+ DQL +I++LG P+++ + + Sbjct: 272 LGAR-YGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAK 330 Query: 287 NYTEFK-FPQI---------------------------KAHPWTKVFRPRTPPEAIALCS 318 N+ K +P+ ++ W + P + Sbjct: 331 NFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLK 390 Query: 319 RLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDT 356 + LE+ P R+TP +A H + LR K P G T Sbjct: 391 QCLEWDPAVRMTPGQALRHPW---LRRRLPKPPTGEKT 425 >4CRL-A nrPDB Length = 406 Score = 118 bits (295), Expect = 5e-27, Method: Compositional matrix adjust. Identities = 84/284 (29%), Positives = 136/284 (47%), Gaps = 42/284 (14%) Query: 96 RELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQT--- 152 RE+ ++R+L H N++ L+ F S ++K + L+ DY ++ + + + +K Sbjct: 68 REIALLRELKHPNVISLQKVFLSHADRK----VWLLFDYAEHDLWHIIKFHRASKANKKP 123 Query: 153 --LPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLL---DPDTAVLKLCDFGSA--- 204 LP VK +YQ+ + Y+H+ + HRD+KP N+L+ P+ +K+ D G A Sbjct: 124 VQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLF 183 Query: 205 ----KQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIF--- 257 K L +P V + +YRAPEL+ GA YT +ID+W+ GC+ AELL +PIF Sbjct: 184 NSPLKPLADLDPVV---VTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCR 240 Query: 258 ------PGDSGVDQLVEIIKVLGTPT---REQIREMNPNYTEFK------FPQIKAHPWT 302 DQL I V+G P E I++M + T K + + Sbjct: 241 QEDIKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYM 300 Query: 303 KVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDP 346 + + + +A L +LL P R+T +A +F L DP Sbjct: 301 EKHKVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYF--LEDP 342 >5JN2-A nrPDB Length = 525 Score = 110 bits (275), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 95/334 (28%), Positives = 149/334 (44%), Gaps = 56/334 (16%) Query: 42 ATPGQGPDRPQEV---SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ-------DK 91 ATPG + Y +V+G GSFG V K +G+ A+K + + DK Sbjct: 52 ATPGMFVQHSTAIFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDK 111 Query: 92 RFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSR--A 149 RE+Q++++LDH NI++L FF +D+ Y LV + VY + + Sbjct: 112 ESLLREVQLLKQLDHPNIMKLYEFF------EDKGYFYLVGE-----VYTGGELFDEIIS 160 Query: 150 KQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDT--AVLKLCDFGSAKQL 207 ++ + + Q+ + Y+H I HRD+KP+NLLL+ + A +++ DFG + Sbjct: 161 RKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHF 220 Query: 208 VRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLV 267 + I + YY APE++ G Y DVWS G +L LL G P F G + D L Sbjct: 221 EASKKMKDKIGTAYYIAPEVLHGT--YDEKCDVWSTGVILYILLSGCPPFNGANEYDILK 278 Query: 268 EIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTA 327 ++ K YT F+ PQ W KV A L ++L Y P+ Sbjct: 279 KVEK--------------GKYT-FELPQ-----WKKV-----SESAKDLIRKMLTYVPSM 313 Query: 328 RLTPLEACAHSFFDELRDPNVKLPNGRDTPALFN 361 R++ +A H + + + D P+L N Sbjct: 314 RISARDALDHEWIQTYTKEQISV----DVPSLDN 343 >4IAN-A nrPDB Length = 358 Score = 107 bits (267), Expect = 9e-24, Method: Compositional matrix adjust. Identities = 89/324 (27%), Positives = 145/324 (44%), Gaps = 56/324 (17%) Query: 63 GNGSFGVVYQAK-LCDSGELVAIKKVLQDKRFKN---RELQIMRKLD--------HCNIV 110 G G F V +A+ + + VA+K + ++ + +EL+ ++KL+ HC + Sbjct: 39 GQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTGLKELEFLKKLNDADPDDKFHC--L 96 Query: 111 RL-RYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 169 RL R+F++ +L LV + + + V + Y + L + V+ Y QLF +L Sbjct: 97 RLFRHFYHKQ-------HLCLVFEPLSMNLREVLKKYGK-DVGLHIKAVRSYSQQLFLAL 148 Query: 170 AYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIF 229 + I H DIKP N+L++ +LKLCDFGSA + + Y+ SR+YRAPE+I Sbjct: 149 KLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVADNDI-TPYLVSRFYRAPEIII 207 Query: 230 GATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIR------- 282 G + Y ID+WS GC L EL G+ +FPG + L + + G + IR Sbjct: 208 GKS-YDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPNKMIRKGVFKDQ 266 Query: 283 --EMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIAL----CSRL---------------- 320 + N N+ + ++ V P + + C RL Sbjct: 267 HFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLADLIGCQRLPEDQRKKVHQLKDLLD 326 Query: 321 --LEYTPTARLTPLEACAHSFFDE 342 L P R++ +A H+F E Sbjct: 327 QILMLDPAKRISINQALQHAFIQE 350 >3MA6-A nrPDB Length = 298 Score = 106 bits (264), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 87/295 (29%), Positives = 137/295 (46%), Gaps = 49/295 (16%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ-------DKRFKNRELQIMRKLDHCN 108 Y +V+G GSFG V K +G+ A+K + + DK RE+Q++++LDH N Sbjct: 34 YKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDHPN 93 Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSR--AKQTLPVIYVKLYMYQLF 166 I++L FF +D+ Y LV + VY + +++ + + Q+ Sbjct: 94 IMKLYEFF------EDKGYFYLVGE-----VYTGGELFDEIISRKRFSEVDAARIIRQVL 142 Query: 167 RSLAYIHSFGICHRDIKPQNLLLDPDT--AVLKLCDFGSAKQLVRGEPNVSYICSRYYRA 224 + Y+H I HRD+KP+NLLL+ + A +++ DFG + + I + YY A Sbjct: 143 SGITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIA 202 Query: 225 PELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREM 284 PE++ G Y DVWS G +L LL G P F G + D L ++ K Sbjct: 203 PEVLHGT--YDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEK------------- 247 Query: 285 NPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSF 339 YT F+ PQ W KV A L ++L Y P+ R++ +A H + Sbjct: 248 -GKYT-FELPQ-----WKKV-----SESAKDLIRKMLTYVPSMRISARDALDHEW 290 >3F3Z-A nrPDB Length = 277 Score = 105 bits (263), Expect = 3e-23, Method: Compositional matrix adjust. Identities = 96/296 (32%), Positives = 141/296 (47%), Gaps = 48/296 (16%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKV----LQD-KRFKNRELQIMRKLDHCNIV 110 YT IG GS+G V A + A KK+ ++D RFK +E++IM+ LDH NI+ Sbjct: 11 YTLENTIGRGSWGEVKIAVQKGTRIRRAAKKIPKYFVEDVDRFK-QEIEIMKSLDHPNII 69 Query: 111 RLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLA 170 RL Y + E ++YL + L E RV K+ M + ++A Sbjct: 70 RL----YETFEDNTDIYLVMELCTGGELFERVVH-----KRVFRESDAARIMKDVLSAVA 120 Query: 171 YIHSFGICHRDIKPQNLLLDPDT--AVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELI 228 Y H + HRD+KP+N L D+ + LKL DFG A + G+ + + + YY +P+++ Sbjct: 121 YCHKLNVAHRDLKPENFLFLTDSPDSPLKLIDFGLAARFKPGKMMRTKVGTPYYVSPQVL 180 Query: 229 FGATDYTSSIDVWSAGCVLAELLLGQPIF--PGDSGVDQLVEIIKVLGTPTREQIREMNP 286 G Y D WSAG ++ LL G P F P DS V ++K IRE Sbjct: 181 EGL--YGPECDEWSAGVMMYVLLCGYPPFSAPTDSEV-----MLK---------IREGT- 223 Query: 287 NYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDE 342 F FP+ W V P+A +L RLL +P R+T L+A H +F++ Sbjct: 224 ----FTFPE---KDWLNV-----SPQAESLIRRLLTKSPKQRITSLQALEHEWFEK 267 >5XZW-A nrPDB Length = 471 Score = 105 bits (262), Expect = 4e-23, Method: Compositional matrix adjust. Identities = 84/270 (31%), Positives = 133/270 (49%), Gaps = 42/270 (15%) Query: 27 KVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDT----------KVIGNGSFGVVYQAKLC 76 KV R + K T+ +A+PG + T +V+G G+F V +A Sbjct: 159 KVDRIRSNLKNTSKIASPGLTSSTASSMVANKTGIFKDFSIIDEVVGQGAFATVKKAIER 218 Query: 77 DSGELVAIKKVLQDKRFKN-----RELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLV 131 +G+ A+K + + K N REL++++KL+H IVRL+ F+ E + Y+ V Sbjct: 219 TTGKTFAVKIISKRKVIGNMDGVTRELEVLQKLNHPRIVRLKGFY----EDTESYYM--V 272 Query: 132 LDYVP--ETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLL 189 +++V + + VA H + + I Q+ ++ YIHS GI HRD+KP N+L+ Sbjct: 273 MEFVSGGDLMDFVAAHGAVGEDAGREIS-----RQILTAIKYIHSMGISHRDLKPDNILI 327 Query: 190 DPDTAVL-KLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGA------------TDYTS 236 + D VL K+ DFG AK G ++ + Y APE+I G +Y+S Sbjct: 328 EQDDPVLVKITDFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSPDEYEERNEYSS 387 Query: 237 SIDVWSAGCVLAELLLGQPIFPGDSGVDQL 266 +D+WS GC++ +L G F G S DQL Sbjct: 388 LVDMWSMGCLVYVILTGHLPFSG-STQDQL 416 >2Z7Q-A nrPDB Length = 321 Score = 104 bits (260), Expect = 6e-23, Method: Compositional matrix adjust. Identities = 80/262 (30%), Positives = 129/262 (49%), Gaps = 28/262 (10%) Query: 29 SRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLC---DSGELVAIK 85 S+D+ K ++ G ++ + KV+G GSFG V+ + DSG L A+K Sbjct: 3 SKDEGVLKEISITHHVKAGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMK 62 Query: 86 KVLQDKRFKNR-------ELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPET 138 VL+ K R E I+ ++H +V+L Y F + G+ L L+LD++ Sbjct: 63 -VLKKATLKVRDRVRTKMERDILADVNHPFVVKLHYAFQTEGK------LYLILDFL--- 112 Query: 139 VYRVARHYSRAKQTLPVIY--VKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVL 196 R ++R + + VK Y+ +L L ++HS GI +RD+KP+N+LLD + + Sbjct: 113 --RGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHI- 169 Query: 197 KLCDFGSAKQLVRGEPNVSYICSRY-YRAPELIFGATDYTSSIDVWSAGCVLAELLLGQP 255 KL DFG +K+ + E C Y APE++ ++ S D WS G ++ E+L G Sbjct: 170 KLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVV-NRQGHSHSADWWSYGVLMFEMLTGSL 228 Query: 256 IFPGDSGVDQLVEIIKV-LGTP 276 F G + + I+K LG P Sbjct: 229 PFQGKDRKETMTLILKAKLGMP 250 >6FDY-U nrPDB Length = 276 Score = 104 bits (259), Expect = 9e-23, Method: Compositional matrix adjust. Identities = 84/284 (29%), Positives = 144/284 (50%), Gaps = 34/284 (11%) Query: 42 ATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQA-KLCDSGELVAIK----KVLQDKRFKN- 95 A PG GP P+ + T+ +G+G++ VY+A D+ E+VAIK K L +N Sbjct: 1 AGPGWGP--PRLDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENL 58 Query: 96 -RELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLP 154 E++I++ + H +IV+L+ F + S D +YL ++++ ++R + ++ LP Sbjct: 59 LTEIEILKGIRHPHIVQLKDFQWDS----DNIYL--IMEFCAGG--DLSR-FIHTRRILP 109 Query: 155 VIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDP-DTAVLKLCDFGSAKQLVRGEPN 213 +++M QL +L ++H I H D+KPQN+LL + LKL DFG A+ + + Sbjct: 110 EKVARVFMQQLASALQFLHERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEK 169 Query: 214 VSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGD--SGVDQLVEIIK 271 S Y APE++ Y + +D+WS G +L E L GQP F S +++ + + Sbjct: 170 HVLRGSPLYMAPEMV-CQRQYDARVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNR 228 Query: 272 VLGTPTR-----------EQIREMNPNYTEFKFPQIKAHPWTKV 304 V+ P R +++ E +P+ F AHPW + Sbjct: 229 VIELPLRPLLSRDCRDLLQRLLERDPS-RRISFQDFFAHPWVDL 271 >5D9K-A nrPDB Length = 330 Score = 103 bits (258), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 78/245 (31%), Positives = 125/245 (51%), Gaps = 28/245 (11%) Query: 46 QGPDRPQEVSYTDTKVIGNGSFGVVYQAKLC---DSGELVAIKKVLQDKRFKNR------ 96 +G ++ + KV+G GSFG V+ K D+ +L A+K VL+ K R Sbjct: 22 EGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMK-VLKKATLKVRDRVRTK 80 Query: 97 -ELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPV 155 E I+ +++H IV+L Y F + G+ L L+LD++ R ++R + + Sbjct: 81 MERDILVEVNHPFIVKLHYAFQTEGK------LYLILDFL-----RGGDLFTRLSKEVMF 129 Query: 156 IY--VKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPN 213 VK Y+ +L +L ++HS GI +RD+KP+N+LLD + + KL DFG +K+ + E Sbjct: 130 TEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHI-KLTDFGLSKESIDHEKK 188 Query: 214 VSYICSRY-YRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKV 272 C Y APE++ +T S D WS G ++ E+L G F G + + I+K Sbjct: 189 AYSFCGTVEYMAPEVV-NRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKA 247 Query: 273 -LGTP 276 LG P Sbjct: 248 KLGMP 252 >4RGJ-A nrPDB Length = 520 Score = 102 bits (255), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 79/297 (26%), Positives = 131/297 (44%), Gaps = 50/297 (16%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ-------DKRFKNRELQIMRKLDHCN 108 Y K++G GSFG V ++ +G AIK + + DK RE+++++ LDH N Sbjct: 62 YKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKESLLREVELLKMLDHIN 121 Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSR--AKQTLPVIYVKLYMYQLF 166 I++L FF +D Y LV D VY + +++ I + Q+ Sbjct: 122 IMKLYEFF------EDNNYYYLVSD-----VYTGGELFDEIISRKRFYEIDAARIIKQIL 170 Query: 167 RSLAYIHSFGICHRDIKPQNLLLD---PDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYR 223 + Y+H + HRD+KP+N+LL+ + ++K+ DFG + + I + YY Sbjct: 171 SGITYMHKNNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEYSKKMKDKIGTAYYI 230 Query: 224 APELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIRE 283 AP+++ G Y D+WS G +L LL G P F G + D L ++ Sbjct: 231 APDVLHGT--YDEKCDIWSCGVILYILLSGCPPFNGSNEYDIL---------------KK 273 Query: 284 MNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF 340 + F PQ K + +A L ++L YT R++ +A H + Sbjct: 274 VEAGKYTFDLPQFK----------KISDKAKDLIKKMLMYTSAVRISARDALEHEWI 320 >4PDS-A nrPDB Length = 347 Score = 99.8 bits (247), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 80/267 (29%), Positives = 131/267 (49%), Gaps = 42/267 (15%) Query: 34 GSKVTTVVATPGQGPDRPQEVSYTDT----------KVIGNGSFGVVYQAKLCDSGELVA 83 G+ T+ +A+PG + T +V+G G+F V +A +G+ + Sbjct: 1 GAMATSKIASPGLTSSTASSMVANKTGIFKDFSIIDEVVGQGAFATVKKAIERTTGKTFS 60 Query: 84 IKKVLQDKRFKN-----RELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVP-- 136 +K + + K N REL++++KL+H IVRL+ F+ E + Y+ V+++V Sbjct: 61 VKIISKRKVIGNMDGVTRELEVLQKLNHPRIVRLKGFY----EDTESYYM--VMEFVSGG 114 Query: 137 ETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVL 196 + + VA H + + I Q+ ++ YIHS GI HRD+KP N+L++ D VL Sbjct: 115 DLMDFVAAHGAVGEDAGREI-----SRQILTAIKYIHSMGISHRDLKPDNILIEQDDPVL 169 Query: 197 -KLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGA------------TDYTSSIDVWSA 243 K+ FG AK G ++ + Y APE+I G +Y+S +D+WS Sbjct: 170 VKITAFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSPDEYEERNEYSSLVDMWSM 229 Query: 244 GCVLAELLLGQPIFPGDSGVDQLVEII 270 GC++ +L G F G S DQL + I Sbjct: 230 GCLVYVILTGHLPFSG-STQDQLYKQI 255 >4YZB-A nrPDB Length = 491 Score = 98.6 bits (244), Expect = 5e-21, Method: Compositional matrix adjust. Identities = 95/321 (29%), Positives = 143/321 (44%), Gaps = 54/321 (16%) Query: 35 SKVTTVVATPG---QGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDK 91 SK + ATPG Q Y +V+G GSFG V K +G+ A+K V+ + Sbjct: 8 SKSDKLAATPGMFVQHSTAAFSDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVK-VISKR 66 Query: 92 RFKNR--------ELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVA 143 + K + E+++++KLDH NI++L FF G Y LV + VY Sbjct: 67 QVKQKTDKELLLKEVELLKKLDHPNIMKLYEFFEDKG------YFYLVTE-----VYTGG 115 Query: 144 RHYSR--AKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDP--DTAVLKLC 199 + +++ + + Q+ + Y+H I HRD+KP+NLLL+ A +++ Sbjct: 116 ELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLENKRKDANIRII 175 Query: 200 DFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPG 259 DFG + + I + YY APE++ G Y DVWS G +L LL G P F G Sbjct: 176 DFGLSTHFESTKKMKDKIGTAYYIAPEVLHGT--YDEKCDVWSTGVILYILLSGCPPFNG 233 Query: 260 DSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSR 319 + D L ++ K G T F PQ W KV P A L + Sbjct: 234 ANEFDILKKVEK--GKFT-------------FDLPQ-----WKKVSEP-----AKDLIRK 268 Query: 320 LLEYTPTARLTPLEACAHSFF 340 +L Y PT R++ +A H + Sbjct: 269 MLAYVPTMRISARDALEHEWL 289 >5YKS-A nrPDB Length = 377 Score = 96.3 bits (238), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 72/267 (26%), Positives = 120/267 (44%), Gaps = 23/267 (8%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKR------FKNRELQIMRKLDHCNI 109 Y K +G G F VV A+ +GE VA+K + + K +E++ M+ + H NI Sbjct: 37 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHPNI 96 Query: 110 VRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 169 VRL Y + + ++YL L L + + +H + L K Y Q+ ++ Sbjct: 97 VRL----YEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDL----AKKYFAQIVHAI 148 Query: 170 AYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIF 229 +Y H + HRD+KP+N++ ++KL DFG + + G+ + S Y APE++ Sbjct: 149 SYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILL 208 Query: 230 GATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYT 289 G ++D+WS G +L L+ GQP F + + L I+ T +E T Sbjct: 209 GDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLIT 268 Query: 290 EF---------KFPQIKAHPWTKVFRP 307 +I+ HPW + P Sbjct: 269 RMLQRDPKRRASLEEIENHPWLQGVDP 295 >3HZT-A nrPDB Length = 467 Score = 95.9 bits (237), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 84/293 (28%), Positives = 127/293 (43%), Gaps = 49/293 (16%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNR-------ELQIMRKLDHCN 108 Y K +G+G++G V K +G AIK + + E+ ++++LDH N Sbjct: 6 YQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDHPN 65 Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRA--KQTLPVIYVKLYMYQLF 166 I++L FF E K YL + VYR + +Q + + M Q+ Sbjct: 66 IMKLYEFF----EDKRNYYLVM-------EVYRGGELFDEIILRQKFSEVDAAVIMKQVL 114 Query: 167 RSLAYIHSFGICHRDIKPQNLLLDPDT--AVLKLCDFGSAKQLVRGEPNVSYICSRYYRA 224 Y+H I HRD+KP+NLLL+ + A++K+ DFG + G + + YY A Sbjct: 115 SGTTYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIA 174 Query: 225 PELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREM 284 PE++ Y DVWS G +L LL G P F G + DQ E ++ + Sbjct: 175 PEVL--RKKYDEKCDVWSCGVILYILLCGYPPFGGQT--DQ-------------EILKRV 217 Query: 285 NPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAH 337 F P WT+V EA L +L Y P+ R++ EA H Sbjct: 218 EKGKFSFDPP-----DWTQV-----SDEAKQLVKLMLTYEPSKRISAEEALNH 260 >3DXN-A nrPDB Length = 287 Score = 95.5 bits (236), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 84/293 (28%), Positives = 127/293 (43%), Gaps = 49/293 (16%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNR-------ELQIMRKLDHCN 108 Y K +G+G++G V K +G AIK + + E+ ++++LDH N Sbjct: 23 YQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDHPN 82 Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRA--KQTLPVIYVKLYMYQLF 166 I++L FF E K YL + VYR + +Q + + M Q+ Sbjct: 83 IMKLYEFF----EDKRNYYLVM-------EVYRGGELFDEIILRQKFSEVDAAVIMKQVL 131 Query: 167 RSLAYIHSFGICHRDIKPQNLLLDPDT--AVLKLCDFGSAKQLVRGEPNVSYICSRYYRA 224 Y+H I HRD+KP+NLLL+ + A++K+ DFG + G + + YY A Sbjct: 132 SGTTYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIA 191 Query: 225 PELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREM 284 PE++ Y DVWS G +L LL G P F G + DQ E ++ + Sbjct: 192 PEVL--RKKYDEKCDVWSCGVILYILLCGYPPFGGQT--DQ-------------EILKRV 234 Query: 285 NPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAH 337 F P WT+V EA L +L Y P+ R++ EA H Sbjct: 235 EKGKFSFDPPD-----WTQV-----SDEAKQLVKLMLTYEPSKRISAEEALNH 277 >3D2K-A nrPDB Length = 272 Score = 95.5 bits (236), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 85/287 (29%), Positives = 126/287 (43%), Gaps = 52/287 (18%) Query: 62 IGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFK-------NRELQIMRKLDHCNIVRLRY 114 +G G FG VY A+ S ++A+K + + + K RE++I L H NI+RL Sbjct: 20 LGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVEHQLRREVEIQSHLRHPNILRLYG 79 Query: 115 FFYSSGEKKDEVYLNLVLDYVP-ETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIH 173 +F+ D + L+L+Y P TVYR + SR + Y+ +L +L+Y H Sbjct: 80 YFH------DATRVYLILEYAPLGTVYRELQKLSRFDEQRTATYIT----ELANALSYCH 129 Query: 174 SFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY-YRAPELIFGAT 232 S + HRDIKP+NLLL + LK+ DFG + +C Y PE+I G Sbjct: 130 SKRVIHRDIKPENLLLGSN-GELKIADFGWSVHAPSSRRTT--LCGTLDYLPPEMIEGRM 186 Query: 233 DYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFK 292 + +D+WS G + E L+G P F + + I +V EF Sbjct: 187 -HDEKVDLWSLGVLCYEFLVGMPPFEAHTYQETYRRISRV-----------------EFT 228 Query: 293 FPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSF 339 FP A L SRLL++ + RLT E H + Sbjct: 229 FPDF------------VTEGARDLISRLLKHNASQRLTLAEVLEHPW 263 >6E2O-A nrPDB Length = 295 Score = 95.1 bits (235), Expect = 5e-20, Method: Compositional matrix adjust. Identities = 60/206 (29%), Positives = 102/206 (49%), Gaps = 12/206 (5%) Query: 58 DTKVIGNGSFGVVYQAKLCDSGELVAIKKV-LQDKRFK---NRELQIMRKLDHCNIVRLR 113 D V+G G++G+VY + + +AIK++ +D R+ + E+ + + L H NIV+ Sbjct: 26 DRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYL 85 Query: 114 YFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIH 173 F +G ++ + ++ VP + Y Q+ L Y+H Sbjct: 86 GSFSENG------FIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLH 139 Query: 174 SFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEP-NVSYICSRYYRAPELI-FGA 231 I HRDIK N+L++ + VLK+ DFG++K+L P ++ + Y APE+I G Sbjct: 140 DNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGP 199 Query: 232 TDYTSSIDVWSAGCVLAELLLGQPIF 257 Y + D+WS GC + E+ G+P F Sbjct: 200 RGYGKAADIWSLGCTIIEMATGKPPF 225 >4WNO-A nrPDB Length = 287 Score = 95.1 bits (235), Expect = 5e-20, Method: Compositional matrix adjust. Identities = 70/236 (29%), Positives = 121/236 (51%), Gaps = 25/236 (10%) Query: 44 PGQG-PDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGEL-VAIK-----KVLQDKRFKNR 96 PG+G + + ++ +IG+G+F VV++ + + +L VA+K + + + + Sbjct: 7 PGRGGTETVGKFEFSRKDLIGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQTLLGK 66 Query: 97 ELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVI 156 E++I+++L H NIV L Y E + VYL V++Y Y A +TL Sbjct: 67 EIKILKELKHENIVAL----YDFQEMANSVYL--VMEYCNGGDLA---DYLHAMRTLSED 117 Query: 157 YVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLL--------DPDTAVLKLCDFGSAKQLV 208 ++L++ Q+ ++ +HS GI HRD+KPQN+LL +P++ +K+ DFG A+ L Sbjct: 118 TIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQ 177 Query: 209 RGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVD 264 + S Y APE+I + Y D+WS G ++ + L G+ F S D Sbjct: 178 SNMMAATLCGSPMYMAPEVIM-SQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQD 232 >4D28-A nrPDB Length = 446 Score = 94.7 bits (234), Expect = 6e-20, Method: Compositional matrix adjust. Identities = 73/208 (35%), Positives = 108/208 (51%), Gaps = 22/208 (10%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNR-------ELQIMRKLDHCN 108 Y + IG G+F V A+ D+G+ VAIK + + KNR E+ IM+ + H N Sbjct: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVP--ETVYRVARHYSRAKQTLPVIYVKLYMYQLF 166 IVRL Y K ++Y+ VL++V E R+ H R K+ + Y QL Sbjct: 71 IVRL----YEVLASKSKIYI--VLEFVTGGELFDRIV-HKGRLKEDES----RKYFQQLV 119 Query: 167 RSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSR-YYRAP 225 ++A+ HS G+ HRD+KP+NLLLD + LK+ DFG + G ++ C Y AP Sbjct: 120 DAVAHCHSKGVYHRDLKPENLLLDTN-GNLKVSDFGLSALPQEGVELLNDTCGTPNYVAP 178 Query: 226 ELIFGATDYTSSIDVWSAGCVLAELLLG 253 E++ G S+ D+WS G +L +L G Sbjct: 179 EVLSGQGYDGSAADIWSCGVILFVILAG 206 >2WQN-A nrPDB Length = 310 Score = 94.4 bits (233), Expect = 8e-20, Method: Compositional matrix adjust. Identities = 69/210 (32%), Positives = 111/210 (52%), Gaps = 17/210 (8%) Query: 60 KVIGNGSFGVVYQAKLCDSGELVAIKKV----LQDKRFKN---RELQIMRKLDHCNIVRL 112 K IG G F VY+A G VA+KKV L D + + +E+ ++++L+H N+++ Sbjct: 38 KKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHPNVIK- 96 Query: 113 RYFFYSSGEKKDEVYLNLVLDYVPE-TVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAY 171 +Y+S + +E LN+VL+ + R+ +H+ + K+ +P V Y QL +L + Sbjct: 97 ---YYASFIEDNE--LNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEH 151 Query: 172 IHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQL-VRGEPNVSYICSRYYRAPELIFG 230 +HS + HRDIKP N+ + T V+KL D G + + S + + YY +PE I Sbjct: 152 MHSRRVMHRDIKPANVFITA-TGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIH- 209 Query: 231 ATDYTSSIDVWSAGCVLAELLLGQPIFPGD 260 Y D+WS GC+L E+ Q F GD Sbjct: 210 ENGYNFKSDIWSLGCLLYEMAALQSPFYGD 239 >4CZT-A nrPDB Length = 464 Score = 94.4 bits (233), Expect = 9e-20, Method: Compositional matrix adjust. Identities = 90/309 (29%), Positives = 139/309 (44%), Gaps = 53/309 (17%) Query: 44 PGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN-------R 96 PG R + Y + +G G+F V A+ ++G+ VAIK + ++K KN R Sbjct: 1 PGIHSGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKR 60 Query: 97 ELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVP--ETVYRVARHYSRAKQTLP 154 E+ M+ + H N++R+ S K ++Y VL++V E +++ + R K+ Sbjct: 61 EISTMKLIKHPNVIRMFEVMAS----KTKIYF--VLEFVTGGELFDKISSN-GRLKED-- 111 Query: 155 VIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAK--QLVRGEP 212 + Y QL ++ Y HS G+ HRD+KP+NLLLD + A LK+ DFG + Q VR + Sbjct: 112 --EARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGA-LKVSDFGLSALPQQVREDG 168 Query: 213 NVSYICSR-YYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIK 271 + C Y APE+I + D+WS G +L L+ G F DS + L + I Sbjct: 169 LLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFE-DSNLTSLYKKI- 226 Query: 272 VLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTP 331 EF P PW A L R+L+ P R+T Sbjct: 227 ---------------FKAEFTCP-----PW-------FSASAKKLIKRILDPNPATRITF 259 Query: 332 LEACAHSFF 340 E + +F Sbjct: 260 AEVIENEWF 268 >4B6L-A nrPDB Length = 281 Score = 94.4 bits (233), Expect = 9e-20, Method: Compositional matrix adjust. Identities = 67/211 (31%), Positives = 100/211 (47%), Gaps = 19/211 (9%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNR-------ELQIMRKLDHC 107 +Y +++G G F Y+A ++G A+K + Q + K E+++ R L H Sbjct: 10 TYLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHR 69 Query: 108 NIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFR 167 +IVR + F E D +Y+ L L + H +A+ TL V+ Y+ Q+ Sbjct: 70 HIVRFSHHF----EDADNIYIFLEL-----CSRKSLAHIWKARHTLLEPEVRYYLRQILS 120 Query: 168 SLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSR-YYRAPE 226 L Y+H GI HRD+K N + + LK+ DFG A +L E IC Y APE Sbjct: 121 GLKYLHQRGILHRDLKLGNFFITENME-LKVGDFGLAARLEPPEQRKKTICGTPNYVAPE 179 Query: 227 LIFGATDYTSSIDVWSAGCVLAELLLGQPIF 257 ++ + DVWS GCV+ LL G P F Sbjct: 180 VLL-RQGHGPEADVWSLGCVMYTLLCGSPPF 209 >1U5R-A nrPDB Length = 348 Score = 94.0 bits (232), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 67/216 (31%), Positives = 112/216 (51%), Gaps = 23/216 (10%) Query: 49 DRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN-------RELQIM 101 D P+++ ++D + IG+GSFG VY A+ + E+VAIKK+ + N +E++ + Sbjct: 50 DDPEKL-FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFL 108 Query: 102 RKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLY 161 +KL H N ++ R G E LV++Y + + + + Q + + V Sbjct: 109 QKLRHPNTIQYR------GCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVT-- 160 Query: 162 MYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY 221 + + LAY+HS + HRD+K N+LL + ++KL DFGSA + P S++ + Y Sbjct: 161 -HGALQGLAYLHSHNMIHRDVKAGNILLS-EPGLVKLGDFGSASIMA---PANSFVGTPY 215 Query: 222 YRAPELIFGATD--YTSSIDVWSAGCVLAELLLGQP 255 + APE+I + Y +DVWS G EL +P Sbjct: 216 WMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKP 251 >2YCR-A nrPDB Length = 323 Score = 94.0 bits (232), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 89/317 (28%), Positives = 147/317 (46%), Gaps = 65/317 (20%) Query: 55 SYTDTKVIGNGSFGVV---YQAKLCDSGELVAIKKVLQDKRFK-------------NREL 98 Y +K +G+G+ G V ++ K C VAIK ++ ++F E+ Sbjct: 11 EYIMSKTLGSGACGEVKLAFERKTCKK---VAIK-IISKRKFAIGSAREADPALNVETEI 66 Query: 99 QIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYV 158 +I++KL+H I++++ FF + ++ Y+ L L E +V + L Sbjct: 67 EILKKLNHPCIIKIKNFFDA-----EDYYIVLELMEGGELFDKVV-----GNKRLKEATC 116 Query: 159 KLYMYQLFRSLAYIHSFGICHRDIKPQNLLL--DPDTAVLKLCDFGSAKQLVRGEPNV-S 215 KLY YQ+ ++ Y+H GI HRD+KP+N+LL + ++K+ DFG +K L GE ++ Sbjct: 117 KLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKIL--GETSLMR 174 Query: 216 YICSR-YYRAPELI--FGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKV 272 +C Y APE++ G Y ++D WS G +L L G P F L Sbjct: 175 TLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSL------ 228 Query: 273 LGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPL 332 ++QI N+ P++ W +V +A+ L +LL P AR T Sbjct: 229 -----KDQITSGKYNF----IPEV----WAEV-----SEKALDLVKKLLVVDPKARFTTE 270 Query: 333 EACAHSFFDELRDPNVK 349 EA H + L+D ++K Sbjct: 271 EALRHPW---LQDEDMK 284 >4UZD-A nrPDB Length = 287 Score = 93.2 bits (230), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 83/287 (28%), Positives = 126/287 (43%), Gaps = 52/287 (18%) Query: 62 IGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFK-------NRELQIMRKLDHCNIVRLRY 114 +G G FG VY A+ S ++A+K + + + K RE++I L H NI+RL Sbjct: 16 LGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYG 75 Query: 115 FFYSSGEKKDEVYLNLVLDYVP-ETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIH 173 +F+ D + L+L+Y P TVYR + S+ + Y+ +L +L+Y H Sbjct: 76 YFH------DATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYIT----ELANALSYCH 125 Query: 174 SFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY-YRAPELIFGAT 232 S + HRDIKP+NLLL LK+ DFG + +C Y PE+I G Sbjct: 126 SKRVIHRDIKPENLLLG-SAGELKIADFGWSVHAPSSRRTT--LCGTLDYLPPEMIEGRM 182 Query: 233 DYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFK 292 + +D+WS G + E L+G+P F ++ + I +V EF Sbjct: 183 -HDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRV-----------------EFT 224 Query: 293 FPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSF 339 FP A L SRLL++ P+ R E H + Sbjct: 225 FPDF------------VTEGARDLISRLLKHNPSQRPMLREVLEHPW 259 >2GCD-A nrPDB Length = 309 Score = 92.4 bits (228), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 67/216 (31%), Positives = 112/216 (51%), Gaps = 23/216 (10%) Query: 49 DRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN-------RELQIM 101 D P+++ ++D + IG+GSFG VY A+ + E+VAIKK+ + N +E++ + Sbjct: 11 DDPEKL-FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFL 69 Query: 102 RKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLY 161 +KL H N ++ R G E LV++Y + + + + Q + + V Sbjct: 70 QKLRHPNTIQYR------GCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVT-- 121 Query: 162 MYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY 221 + + LAY+HS + HRD+K N+LL + ++KL DFGSA + P S++ + Y Sbjct: 122 -HGALQGLAYLHSHNMIHRDVKAGNILLS-EPGLVKLGDFGSASIMA---PANSFVGTPY 176 Query: 222 YRAPELIFGATD--YTSSIDVWSAGCVLAELLLGQP 255 + APE+I + Y +DVWS G EL +P Sbjct: 177 WMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKP 212 >6QAU-A nrPDB Length = 280 Score = 92.0 bits (227), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 69/226 (30%), Positives = 119/226 (52%), Gaps = 24/226 (10%) Query: 53 EVSYTDTKVIGNGSFGVVYQAKLCDSGEL-VAIKKVLQDKRFKN-----RELQIMRKLDH 106 + Y+ ++G+G+F VV++ + + VAIK + + K+ +E++I+++L H Sbjct: 10 DFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKILKELQH 69 Query: 107 CNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLF 166 NIV L Y E + V+L V++Y Y +AK TL ++++++Q+ Sbjct: 70 ENIVAL----YDVQELPNSVFL--VMEYCNGGDLA---DYLQAKGTLSEDTIRVFLHQIA 120 Query: 167 RSLAYIHSFGICHRDIKPQNLLLD----PDTAV----LKLCDFGSAKQLVRGEPNVSYIC 218 ++ +HS GI HRD+KPQN+LL ++V +K+ DFG A+ L Sbjct: 121 AAMRILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAADLCG 180 Query: 219 SRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVD 264 S Y APE+I + Y + D+WS G V+ + L+G+P F +S D Sbjct: 181 SPMYMAPEVIM-SQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQD 225 >2JD5-A nrPDB Length = 373 Score = 92.0 bits (227), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 93/357 (26%), Positives = 160/357 (44%), Gaps = 57/357 (15%) Query: 52 QEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN---RELQIMRKLDHCN 108 ++ Y + +G G F V+ AK + VA+K V DK + E++++++++ + Sbjct: 17 KDARYILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVRGDKVYTEAAEDEIKLLQRVNDAD 76 Query: 109 -----------IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIY 157 I++L F G + V++ +V + + E + + + Y + +P+IY Sbjct: 77 NTKEDSMGANHILKLLDHFNHKG--PNGVHVVMVFEVLGENLLALIKKYEH--RGIPLIY 132 Query: 158 VKLYMYQLFRSLAYIHS-FGICHRDIKPQNLLLD----PDTAV-LKLCDFGSAKQLVRGE 211 VK QL L Y+H GI H DIKP+N+L++ P+ + +K+ D G+A E Sbjct: 133 VKQISKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNA--CWYDE 190 Query: 212 PNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGV------DQ 265 + I +R YR+PE++ GA + D+WS C++ EL+ G +F D G D Sbjct: 191 HYTNSIQTREYRSPEVLLGAP-WGCGADIWSTACLIFELITGDFLFEPDEGHSYTKDDDH 249 Query: 266 LVEIIKVLGTPTREQIREMNPNYTEFKF---------PQIKAHPWTKV------FRPRTP 310 + +II++LG +R N YT F ++K P V F Sbjct: 250 IAQIIELLGELPSYLLR--NGKYTRTFFNSRGLLRNISKLKFWPLEDVLTEKYKFSKDEA 307 Query: 311 PEAIALCSRLLEYTPTARLTPLEACAHSFF------DELRDPNVKL-PNGRDTPALF 360 E S +L+ P R H + +E+R P+ +L +G D P F Sbjct: 308 KEISDFLSPMLQLDPRKRADAGGLVNHPWLKDTLGMEEIRVPDRELYGSGSDIPGWF 364 >3NCG-A nrPDB Length = 486 Score = 92.0 bits (227), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 76/280 (27%), Positives = 122/280 (43%), Gaps = 50/280 (17%) Query: 61 VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN-------RELQIMRKLDHCNIVRLR 113 ++G GSFG V + K + + A+K V+ KN RE+++++KLDH NI++L Sbjct: 29 MLGKGSFGEVLKCKDRITQQEYAVK-VINKASAKNKDTSTILREVELLKKLDHPNIMKLF 87 Query: 114 YFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLY--------MYQL 165 S + Y V Y+ + +I K + + Q+ Sbjct: 88 EILEDSS-----------------SFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQV 130 Query: 166 FRSLAYIHSFGICHRDIKPQNLLLD--PDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYR 223 F + Y+H I HRD+KP+N+LL+ +K+ DFG + + I + YY Sbjct: 131 FSGITYMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYI 190 Query: 224 APELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEI-----------IKV 272 APE++ G Y DVWSAG +L LL G P F G + D L + + Sbjct: 191 APEVLRGT--YDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRVETGKYAFDLPQWRT 248 Query: 273 LGTPTREQIREMNPNYTEFKF--PQIKAHPWTKVFRPRTP 310 + ++ IR+M + + Q HPW + + TP Sbjct: 249 ISDDAKDLIRKMLTFHPSLRITATQCLEHPWIQKYSSETP 288 >6FYV-A nrPDB Length = 337 Score = 91.3 bits (225), Expect = 7e-19, Method: Compositional matrix adjust. Identities = 86/338 (25%), Positives = 144/338 (42%), Gaps = 66/338 (19%) Query: 56 YTDTKVIGNGSFGVVYQA-KLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCN------ 108 Y +G G+FG V + G VA+K V R++ ++ L+H N Sbjct: 16 YEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNS 75 Query: 109 ---IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLP--VIYVKLYMY 163 V++ +F G ++ +V + + + Y + + LP + +++ Y Sbjct: 76 VFRCVQMLEWFDHHG------HVCIVFELLGLSTYD----FIKENSFLPFQIDHIRQMAY 125 Query: 164 QLFRSLAYIHSFGICHRDIKPQNLLLDPDTAV------------------LKLCDFGSAK 205 Q+ +S+ ++H + H D+KP+N+L V +K+ DFGSA Sbjct: 126 QICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSAT 185 Query: 206 QLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQ 265 E + + + +R+YRAPE+I A ++ DVWS GC+L E LG +F + Sbjct: 186 --YDDEHHSTLVSTRHYRAPEVIL-ALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEH 242 Query: 266 LVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTK-------VFRPRTPPEAIALCS 318 L + ++LG P + + + F Q+ W + V R P + LC Sbjct: 243 LAMMERILG-PIPQHMIQKTRKRKYFHHNQL---DWDEHSSAGRYVRRRCKPLKEFMLCH 298 Query: 319 ------------RLLEYTPTARLTPLEACAHSFFDELR 344 R+LEY PT R+T EA H FFD L+ Sbjct: 299 DEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLK 336 >5WAX-A nrPDB Length = 310 Score = 91.3 bits (225), Expect = 7e-19, Method: Compositional matrix adjust. Identities = 78/270 (28%), Positives = 120/270 (44%), Gaps = 38/270 (14%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFK---NRELQIMRKLDHCNIVRL 112 Y + IG+G+FGV + G+LVA+K + + ++ RE+ R L H NI+R Sbjct: 13 YELVRDIGSGNFGVARLMRNRADGQLVAVKYIERGEKIDENVQREIINHRSLRHPNIIRF 72 Query: 113 RYFFYSSGEKKDEVYLNLVLDYVP--ETVYRV--ARHYSRAKQTLPVIYVKLYMYQLFRS 168 + + +L +V++Y E R+ A +S + + + QL Sbjct: 73 KEVILTP------THLAIVMEYASGGELFERICNAGRFSEDE-------ARFFFQQLISG 119 Query: 169 LAYIHSFGICHRDIKPQNLLLDPDTA-VLKLCDFGSAKQLVRGEPNVSYICSRYYRAPEL 227 ++Y HS +CHRD+K +N LLD TA LK+CDFG +K V S + + Y APE+ Sbjct: 120 VSYCHSMQVCHRDLKLENTLLDGSTAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEV 179 Query: 228 IFGATDYTSSIDVWSAGCVLAELLLGQ-PIFPGDSGVDQLVEIIKVLGTPTR-------- 278 + DVWS G L +L+G P D + I ++LG Sbjct: 180 LLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILGVQYSIPDYVHIS 239 Query: 279 -------EQIREMNPNYTEFKFPQIKAHPW 301 +I NP T P+I+ HPW Sbjct: 240 PECQDLISRIFVANPA-TRITIPEIRNHPW 268 >3I6U-A nrPDB Length = 419 Score = 90.9 bits (224), Expect = 8e-19, Method: Compositional matrix adjust. Identities = 88/317 (27%), Positives = 146/317 (46%), Gaps = 65/317 (20%) Query: 55 SYTDTKVIGNGSFGVV---YQAKLCDSGELVAIKKVLQDKRFK-------------NREL 98 Y +K +G+G+ G V ++ K C VAI+ ++ ++F E+ Sbjct: 136 EYIMSKTLGSGACGEVKLAFERKTCKK---VAIR-IISKRKFAIGSAREADPALNVETEI 191 Query: 99 QIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYV 158 +I++KL+H I++++ FF ++ Y+ L L E +V + L Sbjct: 192 EILKKLNHPCIIKIKNFF-----DAEDYYIVLELMEGGELFDKVV-----GNKRLKEATC 241 Query: 159 KLYMYQLFRSLAYIHSFGICHRDIKPQNLLL--DPDTAVLKLCDFGSAKQLVRGEPNV-S 215 KLY YQ+ ++ Y+H GI HRD+KP+N+LL + ++K+ DFG +K L GE ++ Sbjct: 242 KLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKIL--GETSLMR 299 Query: 216 YICSR-YYRAPELI--FGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKV 272 +C Y APE++ G Y ++D WS G +L L G P F L Sbjct: 300 TLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSL------ 353 Query: 273 LGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPL 332 ++QI N+ P++ W +V +A+ L +LL P AR T Sbjct: 354 -----KDQITSGKYNF----IPEV----WAEV-----SEKALDLVKKLLVVDPKARFTTE 395 Query: 333 EACAHSFFDELRDPNVK 349 EA H + L+D ++K Sbjct: 396 EALRHPW---LQDEDMK 409 >3IS5-A nrPDB Length = 285 Score = 90.5 bits (223), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 78/288 (27%), Positives = 132/288 (45%), Gaps = 40/288 (13%) Query: 62 IGNGSFGVVYQAKLCDSGELVAIKKVLQDK-----RFKNRELQIMRKLDHCNIVRLRYFF 116 +G+G+FG V+ + SG IK + +D+ E+++++ LDH NI+++ F Sbjct: 30 LGSGAFGDVHLVEERSSGLERVIKTINKDRSQVPMEQIEAEIEVLKSLDHPNIIKIFEVF 89 Query: 117 YSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFG 176 E +Y+ + E + R+ +R K L YV M Q+ +LAY HS Sbjct: 90 ----EDYHNMYIVMETCEGGELLERIVSAQARGK-ALSEGYVAELMKQMMNALAYFHSQH 144 Query: 177 ICHRDIKPQNLLLDPDT--AVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDY 234 + H+D+KP+N+L + + +K+ DFG A+ E + + + Y APE+ D Sbjct: 145 VVHKDLKPENILFQDTSPHSPIKIIDFGLAELFKSDEHSTNAAGTALYMAPEVF--KRDV 202 Query: 235 TSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFP 294 T D+WSAG V+ LL G F G S L E+ +++ PNY Sbjct: 203 TFKCDIWSAGVVMYFLLTGCLPFTGTS----LEEV--------QQKATYKEPNYA----- 245 Query: 295 QIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDE 342 ++ P T P+A+ L ++L P R + + H +F + Sbjct: 246 -VECRPLT--------PQAVDLLKQMLTKDPERRPSAAQVLHHEWFKQ 284 >3ORZ-A nrPDB Length = 316 Score = 90.1 bits (222), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 86/307 (28%), Positives = 139/307 (45%), Gaps = 60/307 (19%) Query: 60 KVIGNGSFGVVYQAKLCDSGELVAIK-----KVLQDKR--FKNRELQIMRKLDHCNIVRL 112 K++G GSF V A+ + AIK ++++ + + RE +M +LDH V+L Sbjct: 43 KILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKL 102 Query: 113 RYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYI 172 YF + EK +Y L E + Y R + + Y ++ +L Y+ Sbjct: 103 -YFCFQDDEK---LYFGLSYAKNGELL-----KYIRKIGSFDETCTRFYTAEIVSALEYL 153 Query: 173 HSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNV---SYICSRYYRAPELIF 229 H GI HRD+KP+N+LL+ D + ++ DFG+AK L S++ + Y +PEL+ Sbjct: 154 HGKGIIHRDLKPENILLNEDMHI-QITDFGTAKVLSPESKQARANSFVGTAQYVSPELLT 212 Query: 230 GATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYT 289 + SS D+W+ GC++ +L+ G P F + +IIK+ Sbjct: 213 EKSACKSS-DLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKL----------------- 254 Query: 290 EFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARL--------TPLEACAHSFFD 341 E+ FP+ K F P+A L +LL T RL PL+ AH FF+ Sbjct: 255 EYDFPE-------KFF-----PKARDLVEKLLVLDATKRLGCEEMEGYGPLK--AHPFFE 300 Query: 342 ELRDPNV 348 + N+ Sbjct: 301 SVTWENL 307 >5IG1-A nrPDB Length = 344 Score = 90.1 bits (222), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 74/237 (31%), Positives = 111/237 (46%), Gaps = 45/237 (18%) Query: 47 GPDRPQEVSYTDT---------KVIGNGSFGVVYQAKLCDSGELVAIK----KVLQDKRF 93 GP E S+ D VIG G+F V++ +GE+ A+K K L+ Sbjct: 1 GPHMETETSFFDLYDVDLKDKRSVIGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRSSEI 60 Query: 94 KN--RELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQ 151 RE+ I L H +IV +R F +DE + LV +YV S + Sbjct: 61 NKIKREIGICSSLQHEHIVSMRRAF------RDESHFYLVFEYV-----------SGGEL 103 Query: 152 TLPVIYVKLY--------MYQLFRSLAYIHSFGICHRDIKPQNLLL---DPDTAVLKLCD 200 ++ K Y M+Q+ +L + HS I HRD+KP+NLLL DP+ V K+ D Sbjct: 104 FDEIVTRKFYNEKDASACMHQILSALQHCHSKNIIHRDLKPENLLLASKDPNAPV-KITD 162 Query: 201 FGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIF 257 FG A + +G + + Y +PE+I Y +++DVW+ G +L LL+G P F Sbjct: 163 FGLAVIMEQGPTYFGFAGTPGYLSPEVI-RRVPYDTAVDVWACGVILYILLVGYPPF 218 >4FIE-A nrPDB Length = 423 Score = 89.4 bits (220), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 68/209 (32%), Positives = 110/209 (52%), Gaps = 22/209 (10%) Query: 55 SYTDTKV-IGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNR------ELQIMRKLDHC 107 SY D + IG GS G+V A + SG+LVA+KK+ D R + R E+ IMR H Sbjct: 151 SYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKM--DLRKQQRRELLFNEVVIMRDYQHE 208 Query: 108 NIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFR 167 N+V + Y Y G DE+++ V++++ ++R + + + + Sbjct: 209 NVVEM-YNSYLVG---DELWV--VMEFLEGGALTDIVTHTRMNEE----QIAAVCLAVLQ 258 Query: 168 SLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPN-VSYICSRYYRAPE 226 +L+ +H+ G+ HRDIK ++LL D V KL DFG Q+ + P S + + Y+ APE Sbjct: 259 ALSVLHAQGVIHRDIKSDSILLTHDGRV-KLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE 317 Query: 227 LIFGATDYTSSIDVWSAGCVLAELLLGQP 255 LI Y +D+WS G ++ E++ G+P Sbjct: 318 LI-SRLPYGPEVDIWSLGIMVIEMVDGEP 345 >5X8I-B nrPDB Length = 346 Score = 89.0 bits (219), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 85/338 (25%), Positives = 146/338 (43%), Gaps = 66/338 (19%) Query: 56 YTDTKVIGNGSFGVVYQA-KLCDSGELVAIKKVLQDKRF---KNRELQIMRKLDHCN--- 108 Y +G G+FG V + G VA+K V R+ E+Q++ L+ + Sbjct: 15 YEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNS 74 Query: 109 ---IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLP--VIYVKLYMY 163 V++ +F G ++ +V + + + Y + + LP + +++ Y Sbjct: 75 TFRCVQMLEWFEHHG------HICIVFELLGLSTYD----FIKENGFLPFRLDHIRKMAY 124 Query: 164 QLFRSLAYIHSFGICHRDIKPQNLLL---------------DPDTAV---LKLCDFGSAK 205 Q+ +S+ ++HS + H D+KP+N+L D T + +K+ DFGSA Sbjct: 125 QICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSAT 184 Query: 206 QLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQ 265 E + + + +R+YRAPE+I A ++ DVWS GC+L E LG +FP + Sbjct: 185 --YDDEHHSTLVSTRHYRAPEVIL-ALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEH 241 Query: 266 LVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTK-------VFRPRTPPEAIA--- 315 L + ++LG + I++ K+ W + V R P + Sbjct: 242 LAMMERILGPLPKHMIQKTRKR----KYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQ 297 Query: 316 ---------LCSRLLEYTPTARLTPLEACAHSFFDELR 344 L ++LEY P R+T EA H FFD L+ Sbjct: 298 DVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLK 335 >4I6B-A nrPDB Length = 308 Score = 89.0 bits (219), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 62/232 (26%), Positives = 113/232 (48%), Gaps = 25/232 (10%) Query: 34 GSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRF 93 G +++ ++ P G Y+ K +G G F Y+ + ++ A K + + Sbjct: 14 GPEISRIIVDPTTGK------RYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVS 67 Query: 94 K-------NRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHY 146 K ++E+++ R L H ++V+ ++F E K+ +Y+ +L+Y R H Sbjct: 68 KPHQREKIDKEIELHRILHHKHVVQFYHYF----EDKENIYI--LLEYCSR---RSMAHI 118 Query: 147 SRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ 206 +A++ L V+ Y+ Q+ L Y+H I HRD+K N ++ ++ LK+ DFG A + Sbjct: 119 LKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFIN-ESMELKVGDFGLAAR 177 Query: 207 LVRGEPNVSYICSR-YYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIF 257 L E IC Y +PE + + + D+W+ GCV+ +LLG+P F Sbjct: 178 LEPLEHRRRTICGTPNYLSPE-VLNKQGHGAESDIWALGCVMYTMLLGRPPF 228 >3QA8-A nrPDB Length = 676 Score = 89.0 bits (219), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 71/227 (31%), Positives = 114/227 (50%), Gaps = 17/227 (7%) Query: 45 GQGPDRPQEVS--YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRE----- 97 G+ P P + + + +G G FG V + D+GE VAIK+ Q+ KNRE Sbjct: 3 GRSPSLPTQTCGPWEMKERLGTGGFGYVLRWIHQDTGEQVAIKQCRQELSPKNRERWCLE 62 Query: 98 LQIMRKLDHCNIVRLRYFFYSSGEKK---DEVYLNLVLDYVPETVYRVARHYSRAKQTLP 154 +QIM+KL+H N+V R G +K +++ L L ++Y R + L Sbjct: 63 IQIMKKLNHPNVVSAREV--PDGLQKLAPNDLPL-LAMEYCEGGDLRKYLNQFENCCGLK 119 Query: 155 VIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLD--PDTAVLKLCDFGSAKQLVRGEP 212 ++ + + +L Y+H I HRD+KP+N++L P + K+ D G AK+L +GE Sbjct: 120 EGPIRTLLSDISSALRYLHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQGEL 179 Query: 213 NVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLG-QPIFP 258 ++ + Y APEL+ YT ++D WS G + E + G +P P Sbjct: 180 CTEFVGTLQYLAPELL-EQKKYTVTVDYWSFGTLAFECITGFRPFLP 225 >3HKO-A nrPDB Length = 345 Score = 88.6 bits (218), Expect = 5e-18, Method: Compositional matrix adjust. Identities = 83/314 (26%), Positives = 139/314 (44%), Gaps = 74/314 (23%) Query: 62 IGNGSFGVVYQAKLCDSGELVAIKKVLQDK----------RFKNRELQIMRKLDHCNIVR 111 IG GS+GVV A + + AIK + ++K R K E+++M+KL H NI R Sbjct: 34 IGQGSYGVVRVAIENQTRAIRAIKIMNKNKIRQINPKDVERIKT-EVRLMKKLHHPNIAR 92 Query: 112 LRYFFYSSGEKKDEVYLNLVLD-------------YVPETVYRVARHYSRA--------- 149 L Y Y +DE Y+ LV++ ++ ++ + A + Sbjct: 93 L-YEVY-----EDEQYICLVMELCHGGHLLDKLNVFIDDSTGKCAMDVVKTQICPCPECN 146 Query: 150 -----------KQTLPVI----YVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTA 194 +++L + + M Q+F +L Y+H+ GICHRDIKP+N L + + Sbjct: 147 EEAINGSIHGFRESLDFVQREKLISNIMRQIFSALHYLHNQGICHRDIKPENFLFSTNKS 206 Query: 195 V-LKLCDFGSAKQLVRGEPNVSYICSR-----YYRAPELIFGATD-YTSSIDVWSAGCVL 247 +KL DFG +K+ + Y + Y+ APE++ + Y D WSAG +L Sbjct: 207 FEIKLVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEVLNTTNESYGPKCDAWSAGVLL 266 Query: 248 AELLLGQPIFPGDSGVDQLVEII-----------KVLGTPTREQIREMNPNYTEFKFPQI 296 LL+G FPG + D + +++ VL R+ + + + +F + Sbjct: 267 HLLLMGAVPFPGVNDADTISQVLNKKLCFENPNYNVLSPLARDLLSNLLNRNVDERFDAM 326 Query: 297 KA--HPWTKVFRPR 308 +A HPW F + Sbjct: 327 RALQHPWISQFSDK 340 >4JDH-A nrPDB Length = 346 Score = 88.6 bits (218), Expect = 5e-18, Method: Compositional matrix adjust. Identities = 67/209 (32%), Positives = 110/209 (52%), Gaps = 22/209 (10%) Query: 55 SYTDTKV-IGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNR------ELQIMRKLDHC 107 SY D + IG GS G+V A + SG+LVA+KK+ D R + R E+ IMR H Sbjct: 74 SYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKM--DLRKQQRRELLFNEVVIMRDYQHE 131 Query: 108 NIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFR 167 N+V + Y+S DE+++ V++++ ++R + + + + Sbjct: 132 NVVEM----YNSYLVGDELWV--VMEFLEGGALTDIVTHTRMNEE----QIAAVCLAVLQ 181 Query: 168 SLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPN-VSYICSRYYRAPE 226 +L+ +H+ G+ HRDIK ++LL D V KL DFG Q+ + P S + + Y+ APE Sbjct: 182 ALSVLHAQGVIHRDIKSDSILLTHDGRV-KLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE 240 Query: 227 LIFGATDYTSSIDVWSAGCVLAELLLGQP 255 LI Y +D+WS G ++ E++ G+P Sbjct: 241 LI-SRLPYGPEVDIWSLGIMVIEMVDGEP 268 >2Q0N-A nrPDB Length = 301 Score = 88.2 bits (217), Expect = 7e-18, Method: Compositional matrix adjust. Identities = 67/210 (31%), Positives = 113/210 (53%), Gaps = 24/210 (11%) Query: 55 SYTDTKV-IGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNR------ELQIMRKLDHC 107 SY D + IG GS G+V A + SG+LVA+KK+ D R + R E+ IMR H Sbjct: 29 SYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKM--DLRKQQRRELLFNEVVIMRDYQHE 86 Query: 108 NIVRLRYFFYSSGEKKDEVYLNLVLDYVPE-TVYRVARHYSRAKQTLPVIYVKLYMYQLF 166 N+V + Y+S DE+++ V++++ + + H ++ + + + + Sbjct: 87 NVVEM----YNSYLVGDELWV--VMEFLEGGALTDIVTHTRMNEEQIAAVCLAV-----L 135 Query: 167 RSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPN-VSYICSRYYRAP 225 ++L+ +H+ G+ HRDIK ++LL D V KL DFG Q+ + P S + + Y+ AP Sbjct: 136 QALSVLHAQGVIHRDIKSDSILLTHDGRV-KLSDFGFCAQVSKEVPRRKSLVGTPYWMAP 194 Query: 226 ELIFGATDYTSSIDVWSAGCVLAELLLGQP 255 ELI Y +D+WS G ++ E++ G+P Sbjct: 195 ELI-SRLPYGPEVDIWSLGIMVIEMVDGEP 223 >4XBR-A nrPDB Length = 366 Score = 87.8 bits (216), Expect = 8e-18, Method: Compositional matrix adjust. Identities = 67/210 (31%), Positives = 113/210 (53%), Gaps = 24/210 (11%) Query: 55 SYTDTKV-IGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNR------ELQIMRKLDHC 107 SY D + IG GS G+V A + SG+LVA+KK+ D R + R E+ IMR H Sbjct: 94 SYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKM--DLRKQQRRELLFNEVVIMRDYQHE 151 Query: 108 NIVRLRYFFYSSGEKKDEVYLNLVLDYVPE-TVYRVARHYSRAKQTLPVIYVKLYMYQLF 166 N+V + Y+S DE+++ V++++ + + H ++ + + + + Sbjct: 152 NVVEM----YNSYLVGDELWV--VMEFLEGGALTDIVTHTRMNEEQIAAVCLAV-----L 200 Query: 167 RSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPN-VSYICSRYYRAP 225 ++L+ +H+ G+ HRDIK ++LL D V KL DFG Q+ + P S + + Y+ AP Sbjct: 201 QALSVLHAQGVIHRDIKSDSILLTHDGRV-KLSDFGFCAQVSKEVPRRKSLVGTPYWMAP 259 Query: 226 ELIFGATDYTSSIDVWSAGCVLAELLLGQP 255 ELI Y +D+WS G ++ E++ G+P Sbjct: 260 ELI-SRLPYGPEVDIWSLGIMVIEMVDGEP 288 >3UC3-A nrPDB Length = 361 Score = 87.4 bits (215), Expect = 9e-18, Method: Compositional matrix adjust. Identities = 98/347 (28%), Positives = 149/347 (42%), Gaps = 58/347 (16%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFK---NRELQIMRKLDHCNIVRL 112 Y K IG+G+FGV + + ELVA+K + + RE+ R L H NIVR Sbjct: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGAAIDENVQREIINHRSLRHPNIVRF 81 Query: 113 RYFFYSSGEKKDEVYLNLVLDYVP--ETVYRV--ARHYSRAKQTLPVIYVKLYMYQLFRS 168 + + +L ++++Y E R+ A +S + + + QL Sbjct: 82 KEVILTP------THLAIIMEYASGGELYERICNAGRFSEDE-------ARFFFQQLLSG 128 Query: 169 LAYIHSFGICHRDIKPQNLLLDPDTA-VLKLCDFGSAKQLVRGEPNVSYICSRYYRAPEL 227 ++Y HS ICHRD+K +N LLD A LK+CDFG +K V S + + Y APE+ Sbjct: 129 VSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEV 188 Query: 228 IFGATDYTSSI-DVWSAGCVLAELLLGQ-PIFPGDSGVDQLVEIIKVLGTPTREQIREMN 285 + +Y I DVWS G L +L+G P + D I ++L Sbjct: 189 LL-RQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILS----------- 236 Query: 286 PNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRD 345 ++ P R PE L SR+ P R++ E HS+F L++ Sbjct: 237 ---VKYSIPD----------DIRISPECCHLISRIFVADPATRISIPEIKTHSWF--LKN 281 Query: 346 PNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASPPA 392 L N +T + F Q + S L TI+ +I + A+ PA Sbjct: 282 LPADLMNESNTGSQFQEPEQPMQS---LDTIM-----QIISEATIPA 320 >2X4F-A nrPDB Length = 373 Score = 87.4 bits (215), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 72/268 (26%), Positives = 129/268 (48%), Gaps = 33/268 (12%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKV----LQDKRFKNRELQIMRKLDHCNIV 110 + + T+++G G FG V++ + +G +A K + ++DK E+ +M +LDH N++ Sbjct: 90 TVSKTEILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKEEVKNEISVMNQLDHANLI 149 Query: 111 RLRYFFYSSGEKKDEVYLNLVLDYVP--ETVYRVARHYSRAKQTLPVIYVKLYMYQLFRS 168 +L Y + E K+++ L V++YV E R+ L + L+M Q+ Sbjct: 150 QL----YDAFESKNDIVL--VMEYVDGGELFDRIIDE----SYNLTELDTILFMKQICEG 199 Query: 169 LAYIHSFGICHRDIKPQNLL-LDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPEL 227 + ++H I H D+KP+N+L ++ D +K+ DFG A++ E + + APE+ Sbjct: 200 IRHMHQMYILHLDLKPENILCVNRDAKQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEV 259 Query: 228 IFGATDYTSS-IDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNP 286 + D+ S D+WS G + LL G F GD+ + L I+ E+ ++++ Sbjct: 260 V--NYDFVSFPTDMWSVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEFQDISE 317 Query: 287 NYTEF--------KFPQIKA-----HPW 301 EF K +I A HPW Sbjct: 318 EAKEFISKLLIKEKSWRISASEALKHPW 345 >4YNZ-A nrPDB Length = 342 Score = 87.4 bits (215), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 71/223 (31%), Positives = 113/223 (50%), Gaps = 19/223 (8%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN------RELQIMRKLDHCNI 109 Y K +G G G+V C + + VAIK V ++K ++ RE+ I++ ++H ++ Sbjct: 12 YRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHV 71 Query: 110 VRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 169 ++L + +++ YL LVL++V Y K L + + Q+ +L Sbjct: 72 LKLHDVY------ENKKYLYLVLEHVSGGELF---DYLVKKGRLTPKEARKFFRQIISAL 122 Query: 170 AYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYIC-SRYYRAPELI 228 + HS ICHRD+KP+NLLLD + ++ DFG A V G+ + C S +Y PE+I Sbjct: 123 DFCHSHSICHRDLKPENLLLDERNNI-RIADFGMASLQV-GDSLLETSCGSPHYACPEVI 180 Query: 229 FGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIK 271 G DVWS G +L LL+G F D + QL+E +K Sbjct: 181 RGEKYDGRKADVWSCGVILFALLVGALPF-DDDNLRQLLEKVK 222 >3DFA-A nrPDB Length = 286 Score = 87.0 bits (214), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 78/294 (26%), Positives = 124/294 (42%), Gaps = 62/294 (21%) Query: 61 VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN-------RELQIMRKLDHCNIVRLR 113 ++G GSFG V + K + + A+K V+ KN RE+++++KLDH NI++L Sbjct: 29 MLGKGSFGEVLKCKDRITQQEYAVK-VINKASAKNKDTSTILREVELLKKLDHPNIMKLF 87 Query: 114 YFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLY--------MYQL 165 S + Y V Y+ + +I K + + Q+ Sbjct: 88 EILEDSS-----------------SFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQV 130 Query: 166 FRSLAYIHSFGICHRDIKPQNLLLDPDT--AVLKLCDFGSAKQLVRGEPNVSYICSRYYR 223 F + Y+H I HRD+KP+N+LL+ +K+ DFG + + I + YY Sbjct: 131 FSGITYMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYI 190 Query: 224 APELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIRE 283 APE++ G Y DVWSAG +L LL G P F G + D L + Sbjct: 191 APEVLRGT--YDEKCDVWSAGVILYILLSGTPPFYGKNEYDIL---------------KR 233 Query: 284 MNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAH 337 + F PQ W + +A L ++L + P+ R+T + H Sbjct: 234 VETGKYAFDLPQ-----WRTI-----SDDAKDLIRKMLTFHPSLRITATQCLEH 277 >2F57-A nrPDB Length = 317 Score = 86.3 bits (212), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 74/242 (30%), Positives = 127/242 (52%), Gaps = 30/242 (12%) Query: 23 FGSM-KVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGEL 81 F SM +VS ++ + + VV+ P P+E K IG GS G+V A +G+ Sbjct: 19 FQSMSRVSHEQFRAALQLVVS-----PGDPREYLANFIK-IGEGSTGIVCIATEKHTGKQ 72 Query: 82 VAIKKVLQDKRFKNR------ELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYV 135 VA+KK+ D R + R E+ IMR H N+V + YSS DE+++ V++++ Sbjct: 73 VAVKKM--DLRKQQRRELLFNEVVIMRDYHHDNVVDM----YSSYLVGDELWV--VMEFL 124 Query: 136 PE-TVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTA 194 + + H ++ + + + + R+L+Y+H+ G+ HRDIK ++LL D Sbjct: 125 EGGALTDIVTHTRMNEEQIATVCLSV-----LRALSYLHNQGVIHRDIKSDSILLTSDGR 179 Query: 195 VLKLCDFGSAKQLVRGEPN-VSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLG 253 + KL DFG Q+ + P S + + Y+ APE+I Y + +D+WS G ++ E++ G Sbjct: 180 I-KLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVI-SRLPYGTEVDIWSLGIMVIEMIDG 237 Query: 254 QP 255 +P Sbjct: 238 EP 239 >3HDN-A nrPDB Length = 373 Score = 86.3 bits (212), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 69/210 (32%), Positives = 100/210 (47%), Gaps = 26/210 (12%) Query: 60 KVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRF--KNRELQIM-------RKLDHCNIV 110 KVIG GSFG V A+ + E+ KVLQ K K E IM + + H +V Sbjct: 44 KVIGKGSFGKVLLAR-HKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLV 102 Query: 111 RLRYFFYSSGEKKDEVYLNLVLDYV--PETVYRVARHYSRAKQTLPVIYVKLYMYQLFRS 168 L + F ++ D++Y VLDY+ E Y + R + + Y ++ + Sbjct: 103 GLHFSFQTA----DKLYF--VLDYINGGELFYHLQRERCFLEPR-----ARFYAAEIASA 151 Query: 169 LAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSR-YYRAPEL 227 L Y+HS I +RD+KP+N+LLD ++ L DFG K+ + S C Y APE Sbjct: 152 LGYLHSLNIVYRDLKPENILLDSQGHIV-LTDFGLCKENIEHNSTTSTFCGTPEYLAPE- 209 Query: 228 IFGATDYTSSIDVWSAGCVLAELLLGQPIF 257 + Y ++D W G VL E+L G P F Sbjct: 210 VLHKQPYDRTVDWWCLGAVLYEMLYGLPPF 239 >4L42-A nrPDB Length = 346 Score = 85.9 bits (211), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 62/240 (25%), Positives = 122/240 (50%), Gaps = 27/240 (11%) Query: 46 QGPDRPQEVSYTDTKVIGNGSFGVVYQAKL---CDSGELVAIK--------KVLQDKRFK 94 +GP++ + + +V+G G +G V+Q + ++G++ A+K + +D Sbjct: 10 RGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHT 69 Query: 95 NRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVP--ETVYRVARHYSRAKQT 152 E I+ ++ H IV L Y F + G+ L L+L+Y+ E ++ R + T Sbjct: 70 KAERNILEEVKHPFIVDLIYAFQTGGK------LYLILEYLSGGELFMQLEREGIFMEDT 123 Query: 153 LPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVR-GE 211 Y+ ++ +L ++H GI +RD+KP+N++L+ V KL DFG K+ + G Sbjct: 124 -----ACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHV-KLTDFGLCKESIHDGT 177 Query: 212 PNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIK 271 ++ + Y APE++ + + ++D WS G ++ ++L G P F G++ + +I+K Sbjct: 178 VTHTFCGTIEYMAPEILM-RSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILK 236 >4JXF-A nrPDB Length = 266 Score = 85.9 bits (211), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 75/268 (27%), Positives = 122/268 (45%), Gaps = 32/268 (11%) Query: 61 VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFK-------NRELQIMRKLDHCNIVRLR 113 ++G GSF VY+A+ +G VAIK + + +K E++I +L H +I+ L Sbjct: 14 LLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSILELY 73 Query: 114 YFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIH 173 +F E + VYL L + + E + R+ + + +M+Q+ + Y+H Sbjct: 74 NYF----EDSNYVYLVLEMCHNGE----MNRYLKNRVKPFSENEARHFMHQIITGMLYLH 125 Query: 174 SFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSR-YYRAPELIFGAT 232 S GI HRD+ NLLL + + K+ DFG A QL +C Y +PE+ + Sbjct: 126 SHGILHRDLTLSNLLLTRNMNI-KIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSA 184 Query: 233 DYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFK 292 S DVWS GC+ LL+G+P F D+ + L +++ +Y Sbjct: 185 HGLES-DVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVL--------------ADYEMPS 229 Query: 293 FPQIKAHPWTKVFRPRTPPEAIALCSRL 320 F I+A R P + ++L S L Sbjct: 230 FLSIEAKDLIHQLLRRNPADRLSLSSVL 257 >4KS7-A nrPDB Length = 292 Score = 85.5 bits (210), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 84/298 (28%), Positives = 135/298 (45%), Gaps = 49/298 (16%) Query: 62 IGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNR------ELQIMRKLDHCNIVRLRYF 115 IG GS G+V A+ SG VA+K + D R + R E+ IMR H N+V + Y Sbjct: 31 IGEGSTGIVCLAREKHSGRQVAVK--MMDLRKQQRRELLFNEVVIMRDYQHFNVVEM-YK 87 Query: 116 FYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSF 175 Y GE+ + L + + V +V + + + ++LAY+H+ Sbjct: 88 SYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIATVCEAV---------LQALAYLHAQ 138 Query: 176 GICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPN-VSYICSRYYRAPELIFGATDY 234 G+ HRDIK ++LL D V KL DFG Q+ + P S + + Y+ APE+I + Y Sbjct: 139 GVIHRDIKSDSILLTLDGRV-KLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVI-SRSLY 196 Query: 235 TSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFP 294 + +D+WS G ++ E++ G+P + DS V + +++R+ P P Sbjct: 197 ATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAM------------KRLRDSPP-------P 237 Query: 295 QIK-AHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLP 351 ++K +H + V R R+L P R T E H F + P +P Sbjct: 238 KLKNSHKVSPVLRD--------FLERMLVRDPQERATAQELLDHPFLLQTGLPECLVP 287 >5KZ7-A nrPDB Length = 346 Score = 85.5 bits (210), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 72/228 (31%), Positives = 108/228 (47%), Gaps = 34/228 (14%) Query: 49 DRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN--------RELQI 100 ++P +Y K IG G+F V A+ +G+ VA+K + DK N RE++I Sbjct: 28 EQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKII--DKTQLNSSSLQKLFREVRI 85 Query: 101 MRKLDHCNIVRLRYFFYSSGEKKDEVYLNL-------VLDYVPETVYRVARHYSRAKQTL 153 M+ L+H NIV+L + E + +YL + V DY+ R+ +RAK Sbjct: 86 MKVLNHPNIVKL----FEVIETEKTLYLVMEYASGGEVFDYLVAHG-RMKEKEARAK--- 137 Query: 154 PVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPN 213 Q+ ++ Y H I HRD+K +NLLLD D + K+ DFG + + G Sbjct: 138 --------FRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNI-KIADFGFSNEFTFGNKL 188 Query: 214 VSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDS 261 ++ S Y APEL G +DVWS G +L L+ G F G + Sbjct: 189 DTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQN 236 >2HAK-A nrPDB Length = 328 Score = 85.5 bits (210), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 72/222 (32%), Positives = 106/222 (47%), Gaps = 22/222 (9%) Query: 49 DRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN--------RELQI 100 ++P +Y K IG G+F V A+ +G VA+K + DK N RE++I Sbjct: 10 EQPHIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKII--DKTQLNPTSLQKLFREVRI 67 Query: 101 MRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPE-TVYRVARHYSRAKQTLPVIYVK 159 M+ L+H NIV+L F EK L LV++Y V+ + R K+ + Sbjct: 68 MKILNHPNIVKL--FEVIETEKT----LYLVMEYASGGEVFDYLVAHGRMKEK----EAR 117 Query: 160 LYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICS 219 Q+ ++ Y H I HRD+K +NLLLD D + K+ DFG + + G ++ S Sbjct: 118 AKFRQIVSAVQYCHQKYIVHRDLKAENLLLDGDMNI-KIADFGFSNEFTVGNKLDTFCGS 176 Query: 220 RYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDS 261 Y APEL G +DVWS G +L L+ G F G + Sbjct: 177 PPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQN 218 >5ES1-A nrPDB Length = 328 Score = 85.5 bits (210), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 71/222 (31%), Positives = 107/222 (48%), Gaps = 22/222 (9%) Query: 49 DRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN--------RELQI 100 ++P +Y + IG G+F V A+ +G VAIK + DK N RE++I Sbjct: 10 EQPHVGNYRLLRTIGKGNFAKVKLARHILTGREVAIKII--DKTQLNPSSLQKLFREVRI 67 Query: 101 MRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPE-TVYRVARHYSRAKQTLPVIYVK 159 M+ L+H NIV+L F EK L LV++Y V+ + R K+ + Sbjct: 68 MKGLNHPNIVKL--FEVIETEKT----LYLVMEYASAGEVFDYLVSHGRMKEK----EAR 117 Query: 160 LYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICS 219 Q+ ++ Y H I HRD+K +NLLLD + A +K+ DFG + + G ++ S Sbjct: 118 AKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAE-ANIKIADFGFSNEFTLGSKLDTFCGS 176 Query: 220 RYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDS 261 Y APEL G +D+WS G +L L+ G F G + Sbjct: 177 PPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHN 218 >6C9D-A nrPDB Length = 459 Score = 85.5 bits (210), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 72/222 (32%), Positives = 105/222 (47%), Gaps = 22/222 (9%) Query: 49 DRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN--------RELQI 100 ++P +Y K IG G+F V A+ +G VA+K + DK N RE++I Sbjct: 16 EQPHIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKII--DKTQLNPTSLQKLFREVRI 73 Query: 101 MRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPE-TVYRVARHYSRAKQTLPVIYVK 159 M+ L+H NIV+L F EK L LV++Y V+ + R K+ + Sbjct: 74 MKILNHPNIVKL--FEVIETEKT----LYLVMEYASGGEVFDYLVAHGRMKEK----EAR 123 Query: 160 LYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICS 219 Q+ ++ Y H I HRD+K +NLLLD D + K+ DFG + + G + S Sbjct: 124 AKFRQIVSAVQYCHQKYIVHRDLKAENLLLDGDMNI-KIADFGFSNEFTVGNKLDEFCGS 182 Query: 220 RYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDS 261 Y APEL G +DVWS G +L L+ G F G + Sbjct: 183 PPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQN 224 >2BRG-A nrPDB Length = 297 Score = 85.5 bits (210), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 80/280 (28%), Positives = 126/280 (45%), Gaps = 44/280 (15%) Query: 59 TKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFK-----NRELQIMRKLDHCNIVRLR 113 + +G G++G V A + E VA+K V + +E+ I + L+H N+V+ Sbjct: 12 VQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVVK-- 69 Query: 114 YFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIH 173 FY + + YL L E R+ +P + + +QL + Y+H Sbjct: 70 --FYGHRREGNIQYLFLEYCSGGELFDRIEPDIG-----MPEPDAQRFFHQLMAGVVYLH 122 Query: 174 SFGICHRDIKPQNLLLDPDTAVLKLCDFGSAK--QLVRGEPNVSYICSRY-YRAPELIFG 230 GI HRDIKP+NLLLD + LK+ DFG A + E ++ +C Y APEL+ Sbjct: 123 GIGITHRDIKPENLLLD-ERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKR 181 Query: 231 ATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTE 290 + +DVWS G VL +L G+ P D D E Y++ Sbjct: 182 REFHAEPVDVWSCGIVLTAMLAGE--LPWDQPSDSCQE-------------------YSD 220 Query: 291 FKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLT 330 +K + +PW K+ + P +AL ++L P+AR+T Sbjct: 221 WKEKKTYLNPWKKI---DSAP--LALLHKILVENPSARIT 255 >1VZO-A nrPDB Length = 355 Score = 85.1 bits (209), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 66/225 (29%), Positives = 114/225 (50%), Gaps = 25/225 (11%) Query: 60 KVIGNGSFGVVYQAKLC---DSGELVAIK-----KVLQDKRFKNRELQIMRKLDHCN--- 108 KV+G G++G V+ + D+G+L A+K ++Q + + L+H Sbjct: 60 KVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSP 119 Query: 109 -IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFR 167 +V L Y F + E L+L+LDY+ + H S+ ++ V++Y+ ++ Sbjct: 120 FLVTLHYAFQT------ETKLHLILDYINGG--ELFTHLSQ-RERFTEHEVQIYVGEIVL 170 Query: 168 SLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSY-ICSRY-YRAP 225 +L ++H GI +RDIK +N+LLD + V+ L DFG +K+ V E +Y C Y AP Sbjct: 171 ALEHLHKLGIIYRDIKLENILLDSNGHVV-LTDFGLSKEFVADETERAYDFCGTIEYMAP 229 Query: 226 ELIFGA-TDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEI 269 +++ G + + ++D WS G ++ ELL G F D + EI Sbjct: 230 DIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEI 274 >5N23-A nrPDB Length = 352 Score = 85.1 bits (209), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 65/223 (29%), Positives = 114/223 (51%), Gaps = 22/223 (9%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIK-----KVLQDKRFKN--RELQIMRKLDHCN 108 + + +G GSFG V K ++G A+K KV++ K+ ++ E +I + ++ Sbjct: 44 FERIRTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRIQQAVNFPF 103 Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVPE-TVYRVARHYSRAKQTLPVIYVKLYMYQLFR 167 +V+L + F KD L +VL+Y P ++ R R + + + Y Q+ Sbjct: 104 LVKLEFSF------KDNSNLYMVLEYAPGGEMFSHLRRIGRFSEP----HARFYAAQIVL 153 Query: 168 SLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPEL 227 + Y+HS + +RD+KP+NLL+D +K+ DFG AK+ V+G + + Y APE+ Sbjct: 154 TFEYLHSLDLIYRDLKPENLLID-QQGYIKVADFGFAKR-VKGRTPWTLCGTPEYLAPEI 211 Query: 228 IFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEII 270 I + Y ++D W+ G ++ E+ G P F D + Q+ E I Sbjct: 212 IL-SKGYNKAVDWWALGVLIYEMAAGYPPFFADQPI-QIYEKI 252 >2BDW-A nrPDB Length = 362 Score = 85.1 bits (209), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 73/217 (33%), Positives = 106/217 (48%), Gaps = 30/217 (13%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIK----KVLQDKRFK--NRELQIMRKLDHCN 108 +Y + +G G+F VV + +G A K K L + F+ RE +I RKL H N Sbjct: 30 NYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQHPN 89 Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVP-----ETVYRVARH-YSRAKQTLPVIYVKLYM 162 IVRL ++E + LV D V E + VAR YS A + + Sbjct: 90 IVRLH------DSIQEESFHYLVFDLVTGGELFEDI--VAREFYSEADASHCI------- 134 Query: 163 YQLFRSLAYIHSFGICHRDIKPQNLLL--DPDTAVLKLCDFGSAKQLVRGEPNVSYICSR 220 Q+ S+AY HS GI HR++KP+NLLL A +KL DFG A ++ E + + Sbjct: 135 QQILESIAYCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTP 194 Query: 221 YYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIF 257 Y +PE + Y+ +D+W+ G +L LL+G P F Sbjct: 195 GYLSPE-VLKKDPYSKPVDIWACGVILYILLVGYPPF 230 >4B8L-A nrPDB Length = 286 Score = 84.7 bits (208), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 75/271 (27%), Positives = 123/271 (45%), Gaps = 38/271 (14%) Query: 62 IGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN-------RELQIMRKLDHCNIVRLRY 114 +G G FG VY A+ + ++A+K + + + K RE++I L H NI+R+ Sbjct: 23 LGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRREIEIQSHLRHPNILRMYN 82 Query: 115 FFYSSGEKKDEVYLNLVLDYVPE-TVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIH 173 +F+ D + L+L++ P +Y+ + + R + + M +L +L Y H Sbjct: 83 YFH------DRKRIYLMLEFAPRGELYKELQKHGRFDEQRSATF----MEELADALHYCH 132 Query: 174 SFGICHRDIKPQNLLLDPDTAVLKLCDFG---SAKQLVRGEPNVSYICSRY-YRAPELIF 229 + HRDIKP+NLL+ LK+ DFG A L R +C Y PE+I Sbjct: 133 ERKVIHRDIKPENLLMGY-KGELKIADFGWSVHAPSLRR-----RTMCGTLDYLPPEMIE 186 Query: 230 GATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKV-------LGTPTREQIR 282 G T + +D+W AG + E L+G P F S + I+ V L +++ I Sbjct: 187 GKT-HDEKVDLWCAGVLCYEFLVGMPPFDSPSHTETHRRIVNVDLKFPPFLSDGSKDLIS 245 Query: 283 EMNPNYTEFKFP--QIKAHPWTKVFRPRTPP 311 ++ + + P + HPW K R P Sbjct: 246 KLLRYHPPQRLPLKGVMEHPWVKANSRRVLP 276 >5F9E-A nrPDB Length = 353 Score = 84.7 bits (208), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 58/214 (27%), Positives = 105/214 (49%), Gaps = 30/214 (14%) Query: 60 KVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYF---- 115 K++G GSFG V+ A+ + + AIK + +D + +++ C +V R Sbjct: 25 KMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVE-------CTMVEKRVLSLAW 77 Query: 116 -------FYSSGEKKDEVYLNLVLDYVP--ETVYRVARHYSRAKQTLPVIYVKLYMYQLF 166 + + + K+ ++ V++Y+ + +Y + ++ + Y ++ Sbjct: 78 EHPFLTHMFCTFQTKENLFF--VMEYLNGGDLMYHI-----QSCHKFDLSRATFYAAEII 130 Query: 167 RSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSR-YYRAP 225 L ++HS GI +RD+K N+LLD D + K+ DFG K+ + G+ + C Y AP Sbjct: 131 LGLQFLHSKGIVYRDLKLDNILLDKDGHI-KIADFGMCKENMLGDAKTNEFCGTPDYIAP 189 Query: 226 ELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPG 259 E++ G Y S+D WS G +L E+L+GQ F G Sbjct: 190 EILLGQK-YNHSVDWWSFGVLLYEMLIGQSPFHG 222 >3ZUT-A nrPDB Length = 362 Score = 84.7 bits (208), Expect = 7e-17, Method: Compositional matrix adjust. Identities = 67/221 (30%), Positives = 102/221 (46%), Gaps = 21/221 (9%) Query: 41 VATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN---RE 97 V+ P P Y K IG+G+FGV + S ELVA+K + + ++ RE Sbjct: 6 VSGPMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKRE 65 Query: 98 LQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVP--ETVYRV--ARHYSRAKQTL 153 + R L H NIVR + + +L +V++Y E R+ A +S + Sbjct: 66 IINHRSLRHPNIVRFKEVILTP------THLAIVMEYASGGELFERICNAGRFSEDE--- 116 Query: 154 PVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTA-VLKLCDFGSAKQLVRGEP 212 + + QL ++Y H+ +CHRD+K +N LLD A LK+C FG +K V Sbjct: 117 ----ARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICAFGYSKSSVLHSQ 172 Query: 213 NVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLG 253 S + + Y APE++ DVWS G L +L+G Sbjct: 173 PKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVG 213 >4AF3-A nrPDB Length = 292 Score = 84.7 bits (208), Expect = 8e-17, Method: Compositional matrix adjust. Identities = 87/277 (31%), Positives = 124/277 (44%), Gaps = 43/277 (15%) Query: 62 IGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN-------RELQIMRKLDHCNIVRLRY 114 +G G FG VY A+ S +VA+K + + + K RE++I L H NI+RL Sbjct: 31 LGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYN 90 Query: 115 FFYSSGEKKDEVYLNLVLDYVP--ETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYI 172 +FY D + L+L+Y P E + + + +Q I M +L +L Y Sbjct: 91 YFY------DRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI-----MEELADALMYC 139 Query: 173 HSFGICHRDIKPQNLLLDPDTAVLKLCDFG---SAKQLVRGEPNVSYICSRY-YRAPELI 228 H + HRDIKP+NLLL LK+ DFG A L R +C Y PE+I Sbjct: 140 HGKKVIHRDIKPENLLLG-LKGELKIADFGWSVHAPSLRR-----KTMCGTLDYLPPEMI 193 Query: 229 FGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKV-----LGTPTREQ--- 280 G + +D+W G + ELL+G P F S + I+KV PT Q Sbjct: 194 EGRM-HNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPTGAQDLI 252 Query: 281 --IREMNPNYTEFKFPQIKAHPWTKVFRPRT-PPEAI 314 + NP+ Q+ AHPW + R PP A+ Sbjct: 253 SKLLRHNPS-ERLPLAQVSAHPWVRANSRRVLPPSAL 288 >2QNJ-A nrPDB Length = 328 Score = 84.3 bits (207), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 72/222 (32%), Positives = 106/222 (47%), Gaps = 22/222 (9%) Query: 49 DRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN--------RELQI 100 ++P +Y K IG G+F V A+ +G VAIK + DK N RE++I Sbjct: 7 EQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKII--DKTQLNPTSLQKLFREVRI 64 Query: 101 MRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPE-TVYRVARHYSRAKQTLPVIYVK 159 M+ L+H NIV+L F EK L L+++Y V+ + R K+ + Sbjct: 65 MKILNHPNIVKL--FEVIETEKT----LYLIMEYASGGEVFDYLVAHGRMKEK----EAR 114 Query: 160 LYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICS 219 Q+ ++ Y H I HRD+K +NLLLD D + K+ DFG + + G ++ S Sbjct: 115 SKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNI-KIADFGFSNEFTVGGKLDTFCGS 173 Query: 220 RYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDS 261 Y APEL G +DVWS G +L L+ G F G + Sbjct: 174 PPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQN 215 >3MN3-A nrPDB Length = 271 Score = 84.0 bits (206), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 64/204 (31%), Positives = 99/204 (48%), Gaps = 18/204 (8%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIK----KVLQDKRFKNR---ELQIMRKLDHC 107 +Y K +G GSFG V A +G+ VA+K KVL + R E+ +R L H Sbjct: 5 NYQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRHP 64 Query: 108 NIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFR 167 +I++L Y + KDE+ + V++Y ++ Y + + + + Q+ Sbjct: 65 HIIKL----YDVIKSKDEIIM--VIEYAGNELF----DYIVQRDKMSEQEARRFFQQIIS 114 Query: 168 SLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPEL 227 ++ Y H I HRD+KP+NLLLD V K+ DFG + + G + S Y APE+ Sbjct: 115 AVEYCHRHKIVHRDLKPENLLLDEHLNV-KIADFGLSNIMTDGNFLKTSCGSPNYAAPEV 173 Query: 228 IFGATDYTSSIDVWSAGCVLAELL 251 I G +DVWS G +L +L Sbjct: 174 ISGKLYAGPEVDVWSCGVILYVML 197 >3LIJ-A nrPDB Length = 494 Score = 84.0 bits (206), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 68/263 (25%), Positives = 118/263 (44%), Gaps = 43/263 (16%) Query: 96 RELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLD-YVPETVYRVARHYSRAKQTLP 154 E+ +++ LDH NI++L FF E K YL V++ Y ++ H + + Sbjct: 85 EEVAVLKLLDHPNIMKLYDFF----EDKRNYYL--VMECYKGGELFDEIIHRMKFNEVDA 138 Query: 155 VIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDT--AVLKLCDFGSAKQLVRGEP 212 + +K Q+ + Y+H I HRD+KP+NLLL+ A++K+ DFG + + Sbjct: 139 AVIIK----QVLSGVTYLHKHNIVHRDLKPENLLLESKEKDALIKIVDFGLSAVFENQKK 194 Query: 213 NVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKV 272 + + YY APE++ Y DVWS G +L LL G P F G + Sbjct: 195 MKERLGTAYYIAPEVL--RKKYDEKCDVWSIGVILFILLAGYPPFGGQT----------- 241 Query: 273 LGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPL 332 +E +R++ F P+ W V A L ++L++ R++ Sbjct: 242 ----DQEILRKVEKGKYTFDSPE-----WKNV-----SEGAKDLIKQMLQFDSQRRISAQ 287 Query: 333 EACAHSFFDEL---RDPNVKLPN 352 +A H + E+ ++ ++LP+ Sbjct: 288 QALEHPWIKEMCSKKESGIELPS 310 >3KK8-A nrPDB Length = 284 Score = 83.6 bits (205), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 73/217 (33%), Positives = 106/217 (48%), Gaps = 30/217 (13%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIK----KVLQDKRFK--NRELQIMRKLDHCN 108 +Y + +G G+F VV + +G A K K L + F+ RE +I RKL H N Sbjct: 7 NYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQHPN 66 Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVP-----ETVYRVARH-YSRAKQTLPVIYVKLYM 162 IVRL ++E + LV D V E + VAR YS A + + Sbjct: 67 IVRLH------DSIQEESFHYLVFDLVTGGELFEDI--VAREFYSEADASHCI------- 111 Query: 163 YQLFRSLAYIHSFGICHRDIKPQNLLL--DPDTAVLKLCDFGSAKQLVRGEPNVSYICSR 220 Q+ S+AY HS GI HR++KP+NLLL A +KL DFG A ++ E + + Sbjct: 112 QQILESIAYCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTP 171 Query: 221 YYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIF 257 Y +PE + Y+ +D+W+ G +L LL+G P F Sbjct: 172 GYLSPE-VLKKDPYSKPVDIWACGVILYILLVGYPPF 207 >4WB7-A nrPDB Length = 405 Score = 83.2 bits (204), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 66/225 (29%), Positives = 116/225 (51%), Gaps = 25/225 (11%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIK-----KVLQDKRFKN--RELQIMRKLDHC 107 + K +G GSFG V K ++G A+K KV++ K+ ++ E +I++ ++ Sbjct: 97 QFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFP 156 Query: 108 NIVRLRYFFYSSGEKKDEVYLNLVLDYVPE-TVYRVARHYSRAKQTLPVIYVKLYMYQLF 166 +V+L + F KD L +V++YVP ++ R R + + + Y Q+ Sbjct: 157 FLVKLEFSF------KDNSNLYMVMEYVPGGEMFSHLRRIGRFSEP----HARFYAAQIV 206 Query: 167 RSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSR-YYRAP 225 + Y+HS + +RD+KP+NLL+D +++ DFG AK+ V+G +C Y AP Sbjct: 207 LTFEYLHSLDLIYRDLKPENLLID-QQGYIQVTDFGFAKR-VKGRTWT--LCGTPEYLAP 262 Query: 226 ELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEII 270 E+I + Y ++D W+ G ++ E+ G P F D + Q+ E I Sbjct: 263 EIIL-SKGYNKAVDWWALGVLIYEMAAGYPPFFADQPI-QIYEKI 305 >3BHH-A nrPDB Length = 295 Score = 83.2 bits (204), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 88/295 (29%), Positives = 125/295 (42%), Gaps = 60/295 (20%) Query: 62 IGNGSFGVVYQA-KLCDSGELVAIKKVLQDKRFK-------NRELQIMRKLDHCNIVRLR 113 IG G+F VV + KLC E A K++ K+ RE +I R L H NIVRL Sbjct: 12 IGKGAFSVVRRCVKLCTGHEYAA--KIINTKKLSARDHQKLEREARICRLLKHSNIVRLH 69 Query: 114 YFFYSSGEKKDEVYLNLVLDYVP-----ETVYRVARHYSRAKQTLPVIYVKLYMYQLFRS 168 G + LV D V E + VAR Y I Q+ + Sbjct: 70 DSISEEG------FHYLVFDLVTGGELFEDI--VAREYYSEADASHCIQ------QILEA 115 Query: 169 LAYIHSFGICHRDIKPQNLLLDPDT--AVLKLCDFGSAKQLVRGEPNV--SYICSRYYRA 224 + + H G+ HRD+KP+NLLL A +KL DFG A + V+G+ + + Y + Sbjct: 116 VLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIE-VQGDQQAWFGFAGTPGYLS 174 Query: 225 PELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREM 284 PE + Y +D+W+ G +L LL+G P F D +L + IK Sbjct: 175 PE-VLRKEAYGKPVDIWACGVILYILLVGYPPF-WDEDQHKLYQQIKA------------ 220 Query: 285 NPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSF 339 + FP + W V PEA L +++L P R+T EA H + Sbjct: 221 ----GAYDFP---SPEWDTV-----TPEAKNLINQMLTINPAKRITAHEALKHPW 263 >5X3F-B nrPDB Length = 393 Score = 82.8 bits (203), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 70/237 (29%), Positives = 120/237 (50%), Gaps = 27/237 (11%) Query: 43 TPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIK-----KVLQDKRFKN-- 95 TP Q + Q + K +G GSFG V K +SG A+K KV++ K+ ++ Sbjct: 75 TPSQ--NTAQLDQFDRIKTLGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIEHTL 132 Query: 96 RELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPE-TVYRVARHYSRAKQTLP 154 E +I++ ++ +V+L + F KD L +V++YV ++ R R + Sbjct: 133 NEKRILQAVNFPFLVKLEFSF------KDNSNLYMVMEYVAGGEMFSHLRRIGRFSEP-- 184 Query: 155 VIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNV 214 + + Y Q+ + Y+HS + +RD+KP+NLL+D +++ DFG AK+ V+G Sbjct: 185 --HARFYAAQIVLTFEYLHSLDLIYRDLKPENLLID-QQGYIQVTDFGFAKR-VKGRTWT 240 Query: 215 SYICSR-YYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEII 270 +C Y APE+I + Y ++D W+ G ++ E+ G P F D + Q+ E I Sbjct: 241 --LCGTPEYLAPEIIL-SKGYNKAVDWWALGVLIYEMAAGYPPFFADQPI-QIYEKI 293 >5FG8-A nrPDB Length = 285 Score = 82.4 bits (202), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 89/307 (28%), Positives = 135/307 (43%), Gaps = 68/307 (22%) Query: 55 SYTDTKVIGNGSFGVV-----------YQAKLCDSGELVAIKKVLQDKRFKNRELQIMRK 103 +Y + +G G+F +V + AK+ ++ +L A +D + RE +I RK Sbjct: 15 NYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTA-----RDFQKLEREARICRK 69 Query: 104 LDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVP-----ETVYRVARH-YSRAKQTLPVIY 157 L H NIVRL ++E Y LV D V E + VAR YS A + + Sbjct: 70 LHHPNIVRLH------DSIQEENYHYLVFDLVTGGELFEDI--VAREFYSEADASHCI-- 119 Query: 158 VKLYMYQLFRSLAYIHSFGICHRDIKPQNLLL--DPDTAVLKLCDFGSAKQLVRGEPNV- 214 Q+ S+ + H G+ HRD+KP+NLLL A +KL DFG A + V+G+ Sbjct: 120 -----QQILESVNHCHQNGVVHRDLKPENLLLASKAKGAAVKLADFGLAIE-VQGDHQAW 173 Query: 215 -SYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVL 273 + + Y +PE + Y S+D+W+ G +L LL+G P F D +L IK Sbjct: 174 FGFAGTPGYLSPE-VLKKEPYGKSVDIWACGVILYILLVGYPPF-WDEDQHRLYSQIKA- 230 Query: 274 GTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLE 333 + +P + W V PEA L +++L P R+T E Sbjct: 231 ---------------GAYDYPSPE---WDTV-----TPEAKNLINQMLTVNPNKRITAAE 267 Query: 334 ACAHSFF 340 A H + Sbjct: 268 ALKHPWI 274 >6E9W-A nrPDB Length = 443 Score = 82.4 bits (202), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 71/237 (29%), Positives = 113/237 (47%), Gaps = 31/237 (13%) Query: 50 RPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ-------DKRFKNRELQIMR 102 R + Y KVIG G+FG V + + ++ A+K + + D F E IM Sbjct: 98 RMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMA 157 Query: 103 KLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPE-TVYRVARHYSRAKQTLPVIYVKLY 161 + +V+L Y F +D+ YL +V++Y+P + + +Y +P + + Y Sbjct: 158 FANSPWVVQLFYAF------QDDRYLYMVMEYMPGGDLVNLMSNYD-----VPEKWARFY 206 Query: 162 MYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ-----LVRGEPNVSY 216 ++ +L IHS G HRD+KP N+LLD + LKL DFG+ + +VR + V Sbjct: 207 TAEVVLALDAIHSMGFIHRDVKPDNMLLDK-SGHLKLADFGTCMKMNKEGMVRCDTAVG- 264 Query: 217 ICSRYYRAPELI---FGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEII 270 + Y +PE++ G Y D WS G L E+L+G F DS V +I+ Sbjct: 265 --TPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIM 319 >4FR4-A nrPDB Length = 384 Score = 82.4 bits (202), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 66/220 (30%), Positives = 112/220 (50%), Gaps = 26/220 (11%) Query: 49 DRPQEVSYTDTKV---IGNGSFGVVYQAKLCDSGELVAIK-----KVLQDKRFKN--REL 98 D ++V++ ++ IG GSFG V + D+ ++ A+K K ++ +N +EL Sbjct: 7 DENEDVNFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKEL 66 Query: 99 QIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYV--PETVYRVARHYSRAKQTLPVI 156 QIM+ L+H +V L Y F +DE + +V+D + + Y + ++ ++T Sbjct: 67 QIMQGLEHPFLVNLWYSF------QDEEDMFMVVDLLLGGDLRYHLQQNVHFKEET---- 116 Query: 157 YVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSY 216 VKL++ +L +L Y+ + I HRD+KP N+LLD V + DF A L R + Sbjct: 117 -VKLFICELVMALDYLQNQRIIHRDMKPDNILLDEHGHV-HITDFNIAAMLPRETQITTM 174 Query: 217 ICSRYYRAPELIFG--ATDYTSSIDVWSAGCVLAELLLGQ 254 ++ Y APE+ Y+ ++D WS G ELL G+ Sbjct: 175 AGTKPYMAPEMFSSRKGAGYSFAVDWWSLGVTAYELLRGR 214 >1PHK-A nrPDB Length = 298 Score = 82.4 bits (202), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 90/328 (27%), Positives = 133/328 (40%), Gaps = 70/328 (21%) Query: 42 ATPGQGPDRPQEVSYTDTKVIGNGSFGVV-----------YQAKLCD--SGELVAIKKVL 88 A PG +Y +++G G VV Y K+ D G + ++V Sbjct: 5 ALPGSHSTHGFYENYEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQ 64 Query: 89 QDKRFKNRELQIMRKLD-HCNIVRLR--------YFFYSSGEKKDEVYLNLVLDYVPETV 139 + + +E+ I+RK+ H NI++L+ +F KK E++ DY+ E V Sbjct: 65 ELREATLKEVDILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKKGELF-----DYLTEKV 119 Query: 140 YRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLC 199 TL + M L + +H I HRD+KP+N+LLD D + KL Sbjct: 120 ------------TLSEKETRKIMRALLEVICALHKLNIVHRDLKPENILLDDDMNI-KLT 166 Query: 200 DFGSAKQLVRGEPNVSYICSRYYRAPELIFGATD-----YTSSIDVWSAGCVLAELLLGQ 254 DFG + QL GE + Y APE+I + + Y +D+WS G ++ LL G Sbjct: 167 DFGFSCQLDPGEKLREVCGTPSYLAPEIIECSMNDNHPGYGKEVDMWSTGVIMYTLLAGS 226 Query: 255 PIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAI 314 P F + L I M+ NY +F P+ + T Sbjct: 227 PPFWHRKQMLMLRMI--------------MSGNY-QFGSPEWDDYSDT----------VK 261 Query: 315 ALCSRLLEYTPTARLTPLEACAHSFFDE 342 L SR L P R T EA AH FF + Sbjct: 262 DLVSRFLVVQPQKRYTAEEALAHPFFQQ 289 >3ALO-A nrPDB Length = 327 Score = 82.0 bits (201), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 82/303 (27%), Positives = 141/303 (46%), Gaps = 38/303 (12%) Query: 58 DTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ--DKRFKNRELQ----IMRKLDHCNIVR 111 D IG G++G V + SG+++A+K++ D++ + + L +MR D IV+ Sbjct: 26 DLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQ 85 Query: 112 LRYFFYSSGEKKDEVYLNLVLDYVP-ETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLA 170 FY + ++ + ++ + L + Y+ YS +P + ++L Sbjct: 86 ----FYGALFREGDCWICMELMSTSFDKFYKYV--YSVLDDVIPEEILGKITLATVKALN 139 Query: 171 YI-HSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIF 229 ++ + I HRDIKP N+LLD + +KLCDFG + QLV R Y APE I Sbjct: 140 HLKENLKIIHRDIKPSNILLD-RSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERID 198 Query: 230 GATD---YTSSIDVWSAGCVLAELLLGQPIFP-GDSGVDQLVEIIKVLGTP---TREQIR 282 + Y DVWS G L EL G+ +P +S DQL +++K G P + + R Sbjct: 199 PSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVK--GDPPQLSNSEER 256 Query: 283 EMNPNYTEF-------------KFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARL 329 E +P++ F K+ ++ HP+ ++ R A +C ++L+ P Sbjct: 257 EFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEERAVEVACYVC-KILDQMPATPS 315 Query: 330 TPL 332 +P+ Sbjct: 316 SPM 318 >4CQG-A nrPDB Length = 331 Score = 82.0 bits (201), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 74/218 (33%), Positives = 109/218 (50%), Gaps = 27/218 (12%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDK--------RFKNRELQIMRKLDHC 107 Y + IG G F V A +GE+VAIK + DK R K E+ ++ L H Sbjct: 11 YELYETIGTGGFAKVKLACHVLTGEMVAIK--IMDKNALGSDLPRVKT-EIDALKSLRHQ 67 Query: 108 NIVRLRYFFYSSGEKKDEVYLNLVLDYVP--ETVYRVARHYSRAKQTLPVIYVKLYMYQL 165 +I +L Y E K+++++ VL+Y P E + +++ V++ Q+ Sbjct: 68 HICQL----YHVLETKNKIFM--VLEYCPGGELFDYIISQDRLSEEETRVVF-----RQI 116 Query: 166 FRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFG-SAKQLVRGEPNVSYIC-SRYYR 223 ++AY+HS G HRD+KP+NLL D + LKL DFG AK + ++ C S Y Sbjct: 117 LSAVAYVHSQGYAHRDLKPENLLFDENHK-LKLIDFGLCAKPKGNKDYHLQECCGSLAYA 175 Query: 224 APELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDS 261 APELI G + S DVWS G +L L+ G F D+ Sbjct: 176 APELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDN 213 >1S9I-A nrPDB Length = 354 Score = 82.0 bits (201), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 66/208 (31%), Positives = 111/208 (53%), Gaps = 21/208 (10%) Query: 62 IGNGSFGVVYQAKLCDSGELVAIKKVLQDKR--FKN---RELQIMRKLDHCNIVRLRYFF 116 +G G+ GVV + + SG ++A K + + + +N RELQ++ + + IV F Sbjct: 24 LGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAF 83 Query: 117 YSSGEKKDEVYLNLVLDYVPE-TVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYI-HS 174 YS GE +++ ++++ ++ +V + R +P + + R LAY+ Sbjct: 84 YSDGE------ISICMEHMDGGSLDQVLKEAKR----IPEEILGKVSIAVLRGLAYLREK 133 Query: 175 FGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDY 234 I HRD+KP N+L++ +KLCDFG + QL+ N S++ +R Y APE + G T Y Sbjct: 134 HQIMHRDVKPSNILVN-SRGEIKLCDFGVSGQLIDSMAN-SFVGTRSYMAPERLQG-THY 190 Query: 235 TSSIDVWSAGCVLAELLLGQ-PIFPGDS 261 + D+WS G L EL +G+ PI P D+ Sbjct: 191 SVQSDIWSMGLSLVELAVGRYPIPPPDA 218 >1NY3-A nrPDB Length = 400 Score = 82.0 bits (201), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 84/293 (28%), Positives = 127/293 (43%), Gaps = 45/293 (15%) Query: 59 TKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHC-NIVRLRYFFY 117 ++V+G G G V Q + E A+K +LQD RE+++ + C +IVR+ Sbjct: 67 SQVLGLGINGKVLQIFNKRTQEKFALK-MLQDCPKARREVELHWRASQCPHIVRIV---- 121 Query: 118 SSGEKKDEVYLNL-----VLDYVPETV---YRVARHYSRAKQTLPVIYVKLYMYQLFRSL 169 +VY NL L V E + +R R Q M + ++ Sbjct: 122 -------DVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAI 174 Query: 170 AYIHSFGICHRDIKPQNLLLDPD--TAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPEL 227 Y+HS I HRD+KP+NLL A+LKL DFG AK+ + + YY APE Sbjct: 175 QYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPE- 233 Query: 228 IFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPN 287 + G Y S D+WS G ++ LL G P F + G+ + + +IR Sbjct: 234 VLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGL--------AISPGMKTRIR----- 280 Query: 288 YTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF 340 +++FP + W++V E L LL+ PT R+T E H + Sbjct: 281 MGQYEFPNPE---WSEV-----SEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 325 >4FG9-A nrPDB Length = 320 Score = 81.6 bits (200), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 76/274 (27%), Positives = 121/274 (44%), Gaps = 46/274 (16%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIK----KVLQDKRFK-NRELQIMRKLDHCNIV 110 Y V+G G+F V A+ + +LVAIK + L+ K E+ ++ K+ H NIV Sbjct: 20 YDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMENEIAVLHKIKHPNIV 79 Query: 111 RLRYFFYSSGEKKDEVYLNLVL-------DYVPETVYRVARHYSRAKQTLPVIYVKLYMY 163 L + S G +YL + L D + E + R SR ++ Sbjct: 80 ALDDIYESGGH----LYLIMQLVSGGELFDRIVEKGFYTERDASR------------LIF 123 Query: 164 QLFRSLAYIHSFGICHRDIKPQNLL---LDPDTAVLKLCDFGSAKQLVRGEPNVSYICSR 220 Q+ ++ Y+H GI HRD+KP+NLL LD D+ ++ + DFG +K G + + Sbjct: 124 QVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIM-ISDFGLSKMEDPGSVLSTACGTP 182 Query: 221 YYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKV-------- 272 Y APE + Y+ ++D WS G + LL G P F ++ +I+K Sbjct: 183 GYVAPE-VLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPY 241 Query: 273 ---LGTPTREQIREMNPNYTEFKF--PQIKAHPW 301 + ++ IR + E +F Q HPW Sbjct: 242 WDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPW 275 >4RLP-A nrPDB Length = 288 Score = 81.6 bits (200), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 60/226 (26%), Positives = 115/226 (50%), Gaps = 27/226 (11%) Query: 60 KVIGNGSFGVVYQAKL---CDSGELVAIKKV--------LQDKRFKNRELQIMRKLDHCN 108 +V+G G +G V+Q + ++G++ A+K + +D E I+ ++ H Sbjct: 11 RVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPF 70 Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVP--ETVYRVARHYSRAKQTLPVIYVKLYMYQLF 166 IV L Y F + G+ L L+L+Y+ E ++ R + T Y+ ++ Sbjct: 71 IVDLIYAFQTGGK------LYLILEYLSGGELFMQLEREGIFMEDT-----ACFYLAEIS 119 Query: 167 RSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVR-GEPNVSYICSRYYRAP 225 +L ++H GI +RD+KP+N++L+ V KL DFG K+ + G ++ + Y AP Sbjct: 120 MALGHLHQKGIIYRDLKPENIMLNHQGHV-KLTDFGLCKESIHDGTVTHTFCGTIEYMAP 178 Query: 226 ELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIK 271 E++ + + ++D WS G ++ ++L G P F G++ + +I+K Sbjct: 179 EILM-RSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILK 223 >4C0T-A nrPDB Length = 974 Score = 81.6 bits (200), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 66/249 (26%), Positives = 122/249 (48%), Gaps = 36/249 (14%) Query: 31 DKDGSKVTTVVATPGQGPDRPQEVS-YTDTKVIGNGSFGVVYQAKLCDSGELVAIK---- 85 +K G+ V T+ G+ + V+ + K +G GS+ V A +G+ A+K Sbjct: 242 EKKGAAVKTIKTMDGEMKTIRRNVTDFKFGKELGEGSYSTVILATDKITGKQYAVKVLDK 301 Query: 86 -KVLQDKRFK--NRELQIMRKL-DHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVP--ETV 139 ++++K+ K N E + +L + ++ L + F + KD +Y VLDY E + Sbjct: 302 RHIIKEKKVKYVNIEKHALNRLSNRLGVISLYFTF----QDKDSLYF--VLDYASNGELL 355 Query: 140 YRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLC 199 + R+ TL + + Q+ ++ Y+H G+ HRD+KP+N+LLD D +++ Sbjct: 356 TLIKRY-----NTLNEECTRHFGAQILDAIKYMHDNGVIHRDLKPENILLD-DKMRIQIT 409 Query: 200 DFGSAKQLVRGEPNV----------SYICSRYYRAPELIFGATDYTSS-IDVWSAGCVLA 248 DFG+A+ L + S++ + Y +PEL+ Y DVW+ GC++ Sbjct: 410 DFGTARLLEKKNDESEEYPVDVRAKSFVGTAEYVSPELL--ENKYCGKPGDVWAFGCIIY 467 Query: 249 ELLLGQPIF 257 +++ G+P F Sbjct: 468 QMIAGKPPF 476 >2OZA-A nrPDB Length = 356 Score = 81.6 bits (200), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 84/293 (28%), Positives = 127/293 (43%), Gaps = 45/293 (15%) Query: 59 TKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHC-NIVRLRYFFY 117 ++V+G G G V Q + E A+K +LQD RE+++ + C +IVR+ Sbjct: 23 SQVLGLGINGKVLQIFNKRTQEKFALK-MLQDCPKARREVELHWRASQCPHIVRIV---- 77 Query: 118 SSGEKKDEVYLNL-----VLDYVPETV---YRVARHYSRAKQTLPVIYVKLYMYQLFRSL 169 +VY NL L V E + +R R Q M + ++ Sbjct: 78 -------DVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAI 130 Query: 170 AYIHSFGICHRDIKPQNLLLDPD--TAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPEL 227 Y+HS I HRD+KP+NLL A+LKL DFG AK+ + + YY APE Sbjct: 131 QYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPE- 189 Query: 228 IFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPN 287 + G Y S D+WS G ++ LL G P F + G+ + + +IR Sbjct: 190 VLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGL--------AISPGMKTRIR----- 236 Query: 288 YTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF 340 +++FP + W++V E L LL+ PT R+T E H + Sbjct: 237 MGQYEFPNPE---WSEV-----SEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 281 >6ED6-A nrPDB Length = 415 Score = 81.3 bits (199), Expect = 8e-16, Method: Compositional matrix adjust. Identities = 70/231 (30%), Positives = 111/231 (48%), Gaps = 29/231 (12%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ-------DKRFKNRELQIMRKLDHC 107 Y KVIG G+FG V + S ++ A+K + + D F E IM + Sbjct: 89 DYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSP 148 Query: 108 NIVRLRYFFYSSGEKKDEVYLNLVLDYVPE-TVYRVARHYSRAKQTLPVIYVKLYMYQLF 166 +V+L Y F +D+ YL +V++Y+P + + +Y +P + K Y ++ Sbjct: 149 WVVQLFYAF------QDDRYLYMVMEYMPGGDLVNLMSNYD-----VPEKWAKFYTAEVV 197 Query: 167 RSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSY----ICSRYY 222 +L IHS G+ HRD+KP N+LLD LKL DFG+ ++ E + + + + Y Sbjct: 198 LALDAIHSMGLIHRDVKPDNMLLDK-HGHLKLADFGTCMKM--DETGMVHCDTAVGTPDY 254 Query: 223 RAPELI---FGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEII 270 +PE++ G Y D WS G L E+L+G F DS V +I+ Sbjct: 255 ISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIM 305 >4D2V-A nrPDB Length = 356 Score = 80.9 bits (198), Expect = 9e-16, Method: Compositional matrix adjust. Identities = 73/228 (32%), Positives = 113/228 (49%), Gaps = 27/228 (11%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDK--------RFKNRELQIMRKLDHC 107 Y + IG G F V A +GE+VAIK + DK R K E++ ++ L H Sbjct: 31 YELHETIGTGGFAKVKLACHILTGEMVAIK--IMDKNTLGSDLPRIKT-EIEALKNLRHQ 87 Query: 108 NIVRLRYFFYSSGEKKDEVYLNLVLDYVP--ETVYRVARHYSRAKQTLPVIYVKLYMYQL 165 +I +L Y E +++++ VL+Y P E + +++ V++ Q+ Sbjct: 88 HICQL----YHVLETANKIFM--VLEYCPGGELFDYIISQDRLSEEETRVVF-----RQI 136 Query: 166 FRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFG-SAKQLVRGEPNVSYICSRY-YR 223 ++AY+HS G HRD+KP+NLL D + LKL DFG AK + ++ C Y Sbjct: 137 VSAVAYVHSQGYAHRDLKPENLLFD-EYHKLKLIDFGLCAKPKGNKDYHLQACCGALAYA 195 Query: 224 APELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIK 271 APELI G + S DVWS G +L L+ G F D+ + +I++ Sbjct: 196 APELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDTAAALVAKIMR 243 >3KA0-A nrPDB Length = 320 Score = 80.9 bits (198), Expect = 9e-16, Method: Compositional matrix adjust. Identities = 84/293 (28%), Positives = 126/293 (43%), Gaps = 45/293 (15%) Query: 59 TKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHC-NIVRLRYFFY 117 ++V+G G G V Q + E A+K +LQD RE+++ + C +IVR+ Sbjct: 21 SQVLGLGINGKVLQIFNKRTQEKFALK-MLQDCPKARREVELHWRASQCPHIVRIV---- 75 Query: 118 SSGEKKDEVYLNL-----VLDYVPETV---YRVARHYSRAKQTLPVIYVKLYMYQLFRSL 169 +VY NL L V E + +R R Q M + ++ Sbjct: 76 -------DVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAI 128 Query: 170 AYIHSFGICHRDIKPQNLLLDPD--TAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPEL 227 Y+HS I HRD+KP+NLL A+LKL DFG AK+ + YY APE Sbjct: 129 QYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTEPCYTPYYVAPE- 187 Query: 228 IFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPN 287 + G Y S D+WS G ++ LL G P F + G+ + + +IR Sbjct: 188 VLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGL--------AISPGMKTRIR----- 234 Query: 288 YTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF 340 +++FP + W++V E L LL+ PT R+T E H + Sbjct: 235 MGQYEFPNPE---WSEV-----SEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 279 >2V7O-A nrPDB Length = 336 Score = 80.9 bits (198), Expect = 9e-16, Method: Compositional matrix adjust. Identities = 93/337 (27%), Positives = 138/337 (40%), Gaps = 66/337 (19%) Query: 62 IGNGSFGVV-----------YQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIV 110 +G G+F VV Y AK+ ++ +L A +D + RE +I R L H NIV Sbjct: 39 LGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSA-----RDHQKLEREARICRLLKHPNIV 93 Query: 111 RLRYFFYSSGEKKDEVYLNLVLDYVP-----ETVYRVARHYSRAKQTLPVIYVKLYMYQL 165 RL +E + LV D V E + VAR Y I+ Q+ Sbjct: 94 RLH------DSISEEGFHYLVFDLVTGGELFEDI--VAREYYSEADASHCIH------QI 139 Query: 166 FRSLAYIHSFGICHRDIKPQNLLLDPDT--AVLKLCDFGSAKQLVRGEPNV--SYICSRY 221 S+ +IH I HRD+KP+NLLL A +KL DFG A + V+GE + + Sbjct: 140 LESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIE-VQGEQQAWFGFAGTPG 198 Query: 222 YRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQI 281 Y +PE + Y +D+W+ G +L LL+G P F D +L + IK Sbjct: 199 YLSPE-VLRKDPYGKPVDIWACGVILYILLVGYPPF-WDEDQHKLYQQIKA--------- 247 Query: 282 REMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFD 341 + FP + W V PEA L +++L P R+T +A H + Sbjct: 248 -------GAYDFP---SPEWDTV-----TPEAKNLINQMLTINPAKRITADQALKHPWVC 292 Query: 342 ELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILI 378 + + L F + L T+L+ Sbjct: 293 QRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLV 329 >2JC6-A nrPDB Length = 334 Score = 80.9 bits (198), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 73/278 (26%), Positives = 126/278 (45%), Gaps = 36/278 (12%) Query: 46 QGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIK----KVLQDKRFK-NRELQI 100 Q D + + +T +G G+F V A+ +G+L A+K K L+ K E+ + Sbjct: 16 QAEDIKKIFEFKET--LGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAV 73 Query: 101 MRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKL 160 +RK+ H NIV L + E + +YL + L E R+ ++ + Sbjct: 74 LRKIKHENIVALEDIY----ESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTL---- 125 Query: 161 YMYQLFRSLAYIHSFGICHRDIKPQNLLL---DPDTAVLKLCDFGSAKQLVRGEPNVSYI 217 + Q+ ++ Y+H GI HRD+KP+NLL D ++ ++ + DFG +K +G+ + Sbjct: 126 -IRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIM-ISDFGLSKMEGKGDVMSTAC 183 Query: 218 CSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKV----- 272 + Y APE + Y+ ++D WS G + LL G P F ++ +I+K Sbjct: 184 GTPGYVAPE-VLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFD 242 Query: 273 ------LGTPTREQIR---EMNPNYTEFKFPQIKAHPW 301 + ++ IR E +PN + Q HPW Sbjct: 243 SPYWDDISDSAKDFIRNLMEKDPN-KRYTCEQAARHPW 279 >2JAM-A nrPDB Length = 304 Score = 80.9 bits (198), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 80/296 (27%), Positives = 131/296 (44%), Gaps = 48/296 (16%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN----RELQIMRKLDHCNIV 110 ++ +V+G+G+F V+ K +G+L A+K + + F++ E+ +++K+ H NIV Sbjct: 10 TFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSSLENEIAVLKKIKHENIV 69 Query: 111 RLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARH--YSRAKQTLPVIYVKLYMYQLFRS 168 L + E YL + L E R+ Y+ +L + Q+ + Sbjct: 70 TLEDIY----ESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVI-------QQVLSA 118 Query: 169 LAYIHSFGICHRDIKPQNLL-LDP-DTAVLKLCDFGSAKQLVRGEPNVSYICSR-YYRAP 225 + Y+H GI HRD+KP+NLL L P + + + + DFG +K G +S C Y AP Sbjct: 119 VKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNG--IMSTACGTPGYVAP 176 Query: 226 ELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMN 285 E + Y+ ++D WS G + LL G P F ++ + E+I+E Sbjct: 177 E-VLAQKPYSKAVDCWSIGVITYILLCGYPPFYEET------------ESKLFEKIKE-- 221 Query: 286 PNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFD 341 Y EF+ P F A LLE P R T +A +H + D Sbjct: 222 -GYYEFESP----------FWDDISESAKDFICHLLEKDPNERYTCEKALSHPWID 266 >5U6Y-A nrPDB Length = 461 Score = 80.5 bits (197), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 86/299 (28%), Positives = 126/299 (42%), Gaps = 66/299 (22%) Query: 62 IGNGSFGVV-----------YQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIV 110 +G G+F VV Y AK+ ++ +L A +D + RE +I R L H NIV Sbjct: 8 LGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSA-----RDHQKLEREARICRLLKHPNIV 62 Query: 111 RLRYFFYSSGEKKDEVYLNLVLDYVP-----ETVYRVARHYSRAKQTLPVIYVKLYMYQL 165 RL G + L+ D V E + VAR Y I Q+ Sbjct: 63 RLHDSISEEG------HHYLIFDLVTGGELFEDI--VAREYYSEADASHCIQ------QI 108 Query: 166 FRSLAYIHSFGICHRDIKPQNLLLDPDT--AVLKLCDFGSAKQLVRGEPNV--SYICSRY 221 ++ + H G+ HRD+KP+NLLL A +KL DFG A + V GE + + Sbjct: 109 LEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIE-VEGEQQAWFGFAGTPG 167 Query: 222 YRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQI 281 Y +PE + Y +D+W+ G +L LL+G P F D +L + IK Sbjct: 168 YLSPE-VLRKDPYGKPVDLWACGVILYILLVGYPPF-WDEDQHRLYQQIKA--------- 216 Query: 282 REMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF 340 + FP + W V PEA L +++L P+ R+T EA H + Sbjct: 217 -------GAYDFPSPE---WDTV-----TPEAKDLINKMLTINPSKRITAAEALKHPWI 260 >3UIU-A nrPDB Length = 306 Score = 80.5 bits (197), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 64/229 (27%), Positives = 106/229 (46%), Gaps = 32/229 (13%) Query: 49 DRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCN 108 D+ + + + ++IG+G FG V++AK G+ I++V + RE++ + KLDH N Sbjct: 7 DKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIRRVKYNNEKAEREVKALAKLDHVN 66 Query: 109 IVRLR----YFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYS----------------- 147 IV F Y D + + DY PE +R + Sbjct: 67 IVHYNGCWDGFDYDPETSDDSLESS---DYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQ 123 Query: 148 -----RAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFG 202 R ++ V+ ++L+ Q+ + + YIHS + HRD+KP N+ L DT +K+ DFG Sbjct: 124 WIEKRRGEKLDKVLALELFE-QITKGVDYIHSKKLIHRDLKPSNIFL-VDTKQVKIGDFG 181 Query: 203 SAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELL 251 L + Y +PE I + DY +D+++ G +LAELL Sbjct: 182 LVTSLKNDGKRTRSKGTLRYMSPEQI-SSQDYGKEVDLYALGLILAELL 229 >3DB8-A nrPDB Length = 317 Score = 80.5 bits (197), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 80/296 (27%), Positives = 121/296 (40%), Gaps = 54/296 (18%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFK-------NRELQIMRKLDHCN 108 Y + +G G F Y+ D+ E+ A K V + K + E+ I + LD+ + Sbjct: 44 YMRGRFLGKGGFAKCYEITDMDTKEVFAGKVVPKSMLLKPHQKEKMSTEIAIHKSLDNPH 103 Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYR---VARHYSRAKQTLPVIYVKLYMYQL 165 +V FF E D VY+ L E R + H R T P + +M Q Sbjct: 104 VVGFHGFF----EDDDFVYVVL------EICRRRSLLELHKRRKAVTEP--EARYFMRQT 151 Query: 166 FRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQL-VRGEPNVSYICSRYYRA 224 + + Y+H+ + HRD+K NL L+ D V K+ DFG A ++ GE + Y A Sbjct: 152 IQGVQYLHNNRVIHRDLKLGNLFLNDDMDV-KIGDFGLATKIEFDGERKKDLCGTPNYIA 210 Query: 225 PELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREM 284 PE + ++ +D+WS GC+L LL+G+P F + + I K Sbjct: 211 PE-VLCKKGHSFEVDIWSLGCILYTLLVGKPPFETSCLKETYIRIKK------------- 256 Query: 285 NPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF 340 E+ P+ P A AL R+L PT R + E FF Sbjct: 257 ----NEYSVPR------------HINPVASALIRRMLHADPTLRPSVAELLTDEFF 296 >6HXF-B nrPDB Length = 302 Score = 80.1 bits (196), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 63/204 (30%), Positives = 102/204 (50%), Gaps = 20/204 (9%) Query: 62 IGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNR-----ELQIMRKLDHCNIVRLRYFF 116 +G+G+FG VY+AK ++G L A KV++ K + E++I+ DH IV+L + Sbjct: 27 LGDGAFGKVYKAKNKETGALAA-AKVIETKSEEELEDYIVEIEILATCDHPYIVKLLGAY 85 Query: 117 YSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFG 176 Y G+ L +++++ P T P I V Q+ +L ++HS Sbjct: 86 YHDGK------LWIMIEFCPGGAVDAIMLELDRGLTEPQIQV--VCRQMLEALNFLHSKR 137 Query: 177 ICHRDIKPQNLLLDPDTAVLKLCDFG-SAKQLVRGEPNVSYICSRYYRAPELI----FGA 231 I HRD+K N+L+ + + +L DFG SAK L + S+I + Y+ APE++ Sbjct: 138 IIHRDLKAGNVLMTLEGDI-RLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKD 196 Query: 232 TDYTSSIDVWSAGCVLAELLLGQP 255 T Y D+WS G L E+ +P Sbjct: 197 TPYDYKADIWSLGITLIEMAQIEP 220 >3UDB-A nrPDB Length = 317 Score = 80.1 bits (196), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 66/221 (29%), Positives = 100/221 (45%), Gaps = 21/221 (9%) Query: 41 VATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN---RE 97 VA P P Y K IG G+FGV + + ELVA+K + + ++ RE Sbjct: 6 VAGPMDLPIMHDSDRYELVKDIGAGNFGVARLMRDKQANELVAVKYIERGEKIDENVKRE 65 Query: 98 LQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVP--ETVYRV--ARHYSRAKQTL 153 + R L H NIVR + + +L +V++Y E R+ A +S + Sbjct: 66 IINHRSLRHPNIVRFKEVILTP------THLAIVMEYASGGELFERICNAGRFSEDE--- 116 Query: 154 PVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTA-VLKLCDFGSAKQLVRGEP 212 + + QL ++Y H+ + HRD+K +N LLD A LK+ DFG +K V Sbjct: 117 ----ARFFFQQLISGVSYAHAMQVAHRDLKLENTLLDGSPAPRLKIADFGYSKASVLHSQ 172 Query: 213 NVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLG 253 S + + Y APE++ DVWS G L +L+G Sbjct: 173 PKSAVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVG 213 >3Q5I-A nrPDB Length = 504 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 79/301 (26%), Positives = 125/301 (41%), Gaps = 59/301 (19%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNR-----------------E 97 SY + +G+G++G V K + AIK + + + K R E Sbjct: 37 SYFKVRKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYSDDNKNIEKFHEEIYNE 96 Query: 98 LQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVP--ETVYRVARHYSRAKQTLPV 155 + +++ LDH NI++L F +D+ Y LV ++ E ++ + + Sbjct: 97 ISLLKSLDHPNIIKLFDVF------EDKKYFYLVTEFYEGGELFEQIINRHKFDECDAAN 150 Query: 156 IYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVL--KLCDFGSAKQLVRGEPN 213 I M Q+ + Y+H I HRDIKP+N+LL+ ++L K+ DFG + + Sbjct: 151 I-----MKQILSGICYLHKHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSFFSKDYKL 205 Query: 214 VSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVL 273 + + YY APE++ Y DVWS G ++ LL G P F G + D IIK + Sbjct: 206 RDRLGTAYYIAPEVL--KKKYNEKCDVWSCGVIMYILLCGYPPFGGQNDQD----IIKKV 259 Query: 274 GTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLE 333 E Y +F + W + EA L +L Y R T E Sbjct: 260 ---------EKGKYYFDF-------NDWKNI-----SDEAKELIKLMLTYDYNKRCTAEE 298 Query: 334 A 334 A Sbjct: 299 A 299 >2A1A-B nrPDB Length = 284 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 61/215 (28%), Positives = 106/215 (49%), Gaps = 17/215 (7%) Query: 49 DRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCN 108 D+ + + + ++IG+G FG V++AK G+ IK+V + RE++ + KLDH N Sbjct: 6 DKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVN 65 Query: 109 IVRLR----YFFY--------SSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVI 156 IV F Y SS K +++ +++ + R ++ V+ Sbjct: 66 IVHYNGCWDGFDYDPETSSKNSSRSKTKCLFIQ--MEFCDKGTLEQWIEKRRGEKLDKVL 123 Query: 157 YVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSY 216 ++L+ Q+ + + YIHS + +RD+KP N+ L DT +K+ DFG L Sbjct: 124 ALELFE-QITKGVDYIHSKKLINRDLKPSNIFL-VDTKQVKIGDFGLVTSLKNDGKRTRS 181 Query: 217 ICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELL 251 + Y +PE I + DY +D+++ G +LAELL Sbjct: 182 KGTLRYMSPEQI-SSQDYGKEVDLYALGLILAELL 215 >5J5T-A nrPDB Length = 370 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 59/201 (29%), Positives = 101/201 (50%), Gaps = 17/201 (8%) Query: 62 IGNGSFGVVYQAKLCDSGELVAIKKVL----QDKRFKNRELQIMRKLDHCNIVRLRYFFY 117 IG+G++G VY+A+ ++GEL AIK + +D +E+ +M+ H NIV ++ Sbjct: 12 IGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKHPNIVA----YF 67 Query: 118 SSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGI 177 S ++D+++ + +++ + H + L + YV + + L Y+HS G Sbjct: 68 GSYLRRDKLW--ICMEFCGGGSLQDIYHVTGPLSELQIAYVS---RETLQGLYYLHSKGK 122 Query: 178 CHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRG-EPNVSYICSRYYRAPEL--IFGATDY 234 HRDIK N+LL D +KL DFG + Q+ ++I + Y+ APE+ + Y Sbjct: 123 MHRDIKGANILL-TDNGHVKLADFGVSAQITATIAKRKAFIGTPYWMAPEVAAVERKGGY 181 Query: 235 TSSIDVWSAGCVLAELLLGQP 255 D+W+ G EL QP Sbjct: 182 NQLCDLWAVGITAIELAELQP 202 >2W4O-A nrPDB Length = 349 Score = 79.3 bits (194), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 69/216 (31%), Positives = 109/216 (50%), Gaps = 27/216 (12%) Query: 62 IGNGSFGVVYQAKLCDSGELVAIK--KVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSS 119 +G G+ +VY+ K + + A+K K DK+ E+ ++ +L H NI++L+ F + Sbjct: 61 LGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKIVRTEIGVLLRLSHPNIIKLKEIFETP 120 Query: 120 GEKKDEVYLNLVLDYVP--ETVYRVAR--HYSRAKQTLPVIYVKLYMYQLFRSLAYIHSF 175 E ++LVL+ V E R+ +YS V Q+ ++AY+H Sbjct: 121 TE------ISLVLELVTGGELFDRIVEKGYYSERDAADAV-------KQILEAVAYLHEN 167 Query: 176 GICHRDIKPQNLLL---DPDTAVLKLCDFGSAKQLVRGEPNVSYICSR-YYRAPELIFGA 231 GI HRD+KP+NLL PD A LK+ DFG +K +V + + +C Y APE++ G Sbjct: 168 GIVHRDLKPENLLYATPAPD-APLKIADFGLSK-IVEHQVLMKTVCGTPGYCAPEILRGC 225 Query: 232 TDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLV 267 Y +D+WS G + LL G F + G DQ + Sbjct: 226 A-YGPEVDMWSVGIITYILLCGFEPFYDERG-DQFM 259 >2Y7J-A nrPDB Length = 365 Score = 79.3 bits (194), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 84/304 (27%), Positives = 129/304 (42%), Gaps = 53/304 (17%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIK------------KVLQDKRFKNRELQIMRK 103 Y VIG G VV + +G A+K ++ + + RE I+R+ Sbjct: 96 YDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHILRQ 155 Query: 104 L-DHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYM 162 + H +I+ L + SS ++ LV D + + Y K L + M Sbjct: 156 VAGHPHIITLIDSYESSS------FMFLVFDLMRKGELF---DYLTEKVALSEKETRSIM 206 Query: 163 YQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYY 222 L +++++H+ I HRD+KP+N+LLD D ++L DFG + L GE + Y Sbjct: 207 RSLLEAVSFLHANNIVHRDLKPENILLD-DNMQIRLSDFGFSCHLEPGEKLRELCGTPGY 265 Query: 223 RAPELIFGATD-----YTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPT 277 APE++ + D Y +D+W+ G +L LL G P F + L I Sbjct: 266 LAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMI-------- 317 Query: 278 REQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAH 337 M Y +F P+ W R T + L SRLL+ P ARLT +A H Sbjct: 318 ------MEGQY-QFSSPE-----WDD--RSSTVKD---LISRLLQVDPEARLTAEQALQH 360 Query: 338 SFFD 341 FF+ Sbjct: 361 PFFE 364 >6BDL-A nrPDB Length = 347 Score = 79.3 bits (194), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 62/207 (29%), Positives = 97/207 (46%), Gaps = 21/207 (10%) Query: 62 IGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN--------RELQIMRKLDHCNIVRLR 113 +G G FG V +L K+L+ + + E QIM+ IVRL Sbjct: 42 LGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLY 101 Query: 114 YFFYSSGEKKDEVYLNLVLDY-VPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYI 172 F KD YL ++++ + ++ + R + + + Y + + AY+ Sbjct: 102 RTF------KDSKYLYMLMEACLGGELWTILRDRGSFEDST----TRFYTACVVEAFAYL 151 Query: 173 HSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGAT 232 HS GI +RD+KP+NL+LD KL DFG AK++ G+ ++ + Y APE+I Sbjct: 152 HSKGIIYRDLKPENLILD-HRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKG 210 Query: 233 DYTSSIDVWSAGCVLAELLLGQPIFPG 259 + S D WS G ++ ELL G P F G Sbjct: 211 -HDISADYWSLGILMYELLTGSPPFSG 236 >5D7A-A nrPDB Length = 308 Score = 79.3 bits (194), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 64/210 (30%), Positives = 107/210 (50%), Gaps = 19/210 (9%) Query: 59 TKVIGNGSFGVVYQAKLCDSGELVAIK--KVLQDKRFK-NRELQIMRKLDHC-NIVRLRY 114 +++GNG++G VY+ + +G+L AIK V D+ + +E+ +++K H NI Sbjct: 22 VELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIATYYG 81 Query: 115 FFYSSGEKKDEVYLNLVLDYV-PETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIH 173 F + L LV+++ +V + + + TL ++ ++ R L+++H Sbjct: 82 AFIKKNPPGMDDQLWLVMEFCGAGSVTDLIK--NTKGNTLKEEWIAYICREILRGLSHLH 139 Query: 174 SFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVR--GEPNVSYICSRYYRAPELIFGA 231 + HRDIK QN+LL + A +KL DFG + QL R G N ++I + Y+ APE+I A Sbjct: 140 QHKVIHRDIKGQNVLL-TENAEVKLVDFGVSAQLDRTVGRRN-TFIGTPYWMAPEVI--A 195 Query: 232 TD------YTSSIDVWSAGCVLAELLLGQP 255 D Y D+WS G E+ G P Sbjct: 196 CDENPDATYDFKSDLWSLGITAIEMAEGAP 225 >2WTK-C nrPDB Length = 305 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 71/241 (29%), Positives = 109/241 (45%), Gaps = 45/241 (18%) Query: 95 NRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNL---------VLDYVPETVYRVARH 145 +E+Q++R+L H N+++L Y+ E+K ++Y+ + +LD VPE Sbjct: 54 KKEIQLLRRLRHKNVIQLVDVLYN--EEKQKMYMVMEYCVCGMQEMLDSVPE-------- 103 Query: 146 YSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAK 205 + PV Y QL L Y+HS GI H+DIKP NLLL LK+ G A+ Sbjct: 104 -----KRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLT-TGGTLKISALGVAE 157 Query: 206 QL---VRGEPNVSYICSRYYRAPELIFGATDYTS-SIDVWSAGCVLAELLLGQPIFPGDS 261 L + + S ++ PE+ G ++ +D+WSAG L + G F GD+ Sbjct: 158 ALHPFAADDTCRTSQGSPAFQPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDN 217 Query: 262 GVDQLVEIIKV--------LGTPTREQIREM---NPNYTEFKFPQIKAHPWTKVFRPRTP 310 + +L E I G P + ++ M P F QI+ H W FR + P Sbjct: 218 -IYKLFENIGKGSYAIPGDCGPPLSDLLKGMLEYEPA-KRFSIRQIRQHSW---FRKKHP 272 Query: 311 P 311 P Sbjct: 273 P 273 >2VZ6-A nrPDB Length = 313 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 86/299 (28%), Positives = 125/299 (41%), Gaps = 66/299 (22%) Query: 62 IGNGSFGVV-----------YQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIV 110 +G G+F VV Y AK+ ++ +L A +D + RE +I R L H NIV Sbjct: 30 LGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSA-----RDHQKLEREARICRLLKHPNIV 84 Query: 111 RLRYFFYSSGEKKDEVYLNLVLDYVP-----ETVYRVARHYSRAKQTLPVIYVKLYMYQL 165 RL G L+ D V E + VAR Y I Q+ Sbjct: 85 RLHDSISEEGHH------YLIFDLVTGGELFEDI--VAREYYSEADASHCIQ------QI 130 Query: 166 FRSLAYIHSFGICHRDIKPQNLLLDPDT--AVLKLCDFGSAKQLVRGEPNV--SYICSRY 221 ++ + H G+ HRD+KP+NLLL A +KL DFG A + V GE + + Sbjct: 131 LEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIE-VEGEQQAWFGFAGTPG 189 Query: 222 YRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQI 281 Y +PE + Y +D+W+ G +L LL+G P F D +L + IK Sbjct: 190 YLSPE-VLRKDPYGKPVDLWACGVILYILLVGYPPF-WDEDQHRLYQQIKA--------- 238 Query: 282 REMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF 340 + FP + W V PEA L +++L P+ R+T EA H + Sbjct: 239 -------GAYDFPSPE---WDTV-----TPEAKDLINKMLTINPSKRITAAEALKHPWI 282 >5KKR-C nrPDB Length = 395 Score = 79.0 bits (193), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 63/209 (30%), Positives = 112/209 (53%), Gaps = 23/209 (11%) Query: 62 IGNGSFGVVYQAKLCDSGELVAIKKVLQDKR--FKN---RELQIMRKLDHCNIVRLRYFF 116 +G G+ GVV++ SG ++A K + + + +N RELQ++ + + IV F Sbjct: 76 LGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAF 135 Query: 117 YSSGEKKDEVYLNLVLDYVPE-TVYRVARHYSRA-KQTLPVIYVKLYMYQLFRSLAYI-H 173 YS GE +++ ++++ ++ +V + R +Q L + + + + L Y+ Sbjct: 136 YSDGE------ISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAV-----IKGLTYLRE 184 Query: 174 SFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATD 233 I HRD+KP N+L++ +KLCDFG + QL+ N S++ +R Y +PE + G T Sbjct: 185 KHKIMHRDVKPSNILVN-SRGEIKLCDFGVSGQLIDSMAN-SFVGTRSYMSPERLQG-TH 241 Query: 234 YTSSIDVWSAGCVLAELLLGQ-PIFPGDS 261 Y+ D+WS G L E+ +G+ PI P D+ Sbjct: 242 YSVQSDIWSMGLSLVEMAVGRYPIPPPDA 270 >4U41-A nrPDB Length = 332 Score = 79.0 bits (193), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 64/211 (30%), Positives = 107/211 (50%), Gaps = 21/211 (9%) Query: 59 TKVIGNGSFGVVYQAKLCDSGELVAIKKV---LQDKRFKNRELQIMRKLDHCNIVRLRY- 114 +V+GNG++G VY+ + +G+L AIK + ++ E+ +++K H + Y Sbjct: 29 VEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKYSHHRNIATYYG 88 Query: 115 -FFYSSGEKKDEVYLNLVLDYV-PETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYI 172 F S D+ L LV+++ ++ + + + TL ++ ++ R LA++ Sbjct: 89 AFIKKSPPGHDD-QLWLVMEFCGAGSITDLVK--NTKGNTLKEDWIAYISREILRGLAHL 145 Query: 173 HSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVR--GEPNVSYICSRYYRAPELIF- 229 H + HRDIK QN+LL + A +KL DFG + QL R G N ++I + Y+ APE+I Sbjct: 146 HIHHVIHRDIKGQNVLL-TENAEVKLVDFGVSAQLDRTVGRRN-TFIGTPYWMAPEVIAC 203 Query: 230 -----GATDYTSSIDVWSAGCVLAELLLGQP 255 DY S D+WS G E+ G P Sbjct: 204 DENPDATYDYRS--DLWSCGITAIEMAEGAP 232 >2VN9-A nrPDB Length = 301 Score = 79.0 bits (193), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 88/299 (29%), Positives = 127/299 (42%), Gaps = 66/299 (22%) Query: 62 IGNGSFGVV-----------YQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIV 110 +G G+F VV Y AK+ ++ +L A +D + RE +I R L H NIV Sbjct: 12 LGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSA-----RDHQKLEREARICRLLKHPNIV 66 Query: 111 RLRYFFYSSGEKKDEVYLNLVLDYVP-----ETVYRVARHYSRAKQTLPVIYVKLYMYQL 165 RL G + LV D V E + VAR Y I Q+ Sbjct: 67 RLHDSISEEG------FHYLVFDLVTGGELFEDI--VAREYYSEADASHCIQ------QI 112 Query: 166 FRSLAYIHSFGICHRDIKPQNLLLDPDT--AVLKLCDFGSAKQLVRGEPNV--SYICSRY 221 S+ + H GI HRD+KP+NLLL + A +KL DFG A + V+G+ + + Sbjct: 113 LESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIE-VQGDQQAWFGFAGTPG 171 Query: 222 YRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQI 281 Y +PE + Y +D+W+ G +L LL+G P F D +L + IK Sbjct: 172 YLSPE-VLRKDPYGKPVDMWACGVILYILLVGYPPF-WDEDQHRLYQQIKA--------- 220 Query: 282 REMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF 340 + FP + W V PEA L +++L P R+T EA H + Sbjct: 221 -------GAYDFP---SPEWDTV-----TPEAKDLINKMLTINPAKRITASEALKHPWI 264 >4RA4-A nrPDB Length = 355 Score = 79.0 bits (193), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 79/301 (26%), Positives = 132/301 (43%), Gaps = 61/301 (20%) Query: 44 PGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRK 103 P DR + + V+G GSFG V A + EL AIK + +D ++ +++ Sbjct: 10 PSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVE---- 65 Query: 104 LDHCNIVRLRYF-----------FYSSGEKKDEVYLNLVLDYV--PETVYRVARHYSRAK 150 C +V R +S + D +Y V++YV + +Y + + + K Sbjct: 66 ---CTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYF--VMEYVNGGDLMYHI-QQVGKFK 119 Query: 151 QTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ-LVR 209 + V Y LF ++H GI +RD+K N++LD + + K+ DFG K+ ++ Sbjct: 120 EPQAVFYAAEISIGLF----FLHKRGIIYRDLKLDNVMLDSEGHI-KIADFGMCKEHMMD 174 Query: 210 GEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEI 269 G ++ + Y APE+I Y S+D W+ G +L E+L GQP F G+ D+L Sbjct: 175 GVTTRTFCGTPDYIAPEII-AYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDE-DELF-- 230 Query: 270 IKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRT-PPEAIALCSRLLEYTPTAR 328 + I E N +Y P++ EA+++C L+ P R Sbjct: 231 ---------QSIMEHNVSY------------------PKSLSKEAVSICKGLMTKHPAKR 263 Query: 329 L 329 L Sbjct: 264 L 264 >5UNP-A nrPDB Length = 369 Score = 78.6 bits (192), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 59/237 (24%), Positives = 101/237 (42%), Gaps = 38/237 (16%) Query: 154 PVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLL------------------DPDTAV 195 P+ V+ +QL +++ ++H + H D+KP+N+L + Sbjct: 136 PIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTA 195 Query: 196 LKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQP 255 +++ DFGSA E + + + +R+YRAPE+I ++ DVWS GC++ E +G Sbjct: 196 VRVVDFGSAT--FDHEHHSTIVSTRHYRAPEVIL-ELGWSQPCDVWSIGCIIFEYYVGFT 252 Query: 256 IFPGDSGVDQLVEIIKVLGTPTREQIR-------------EMNPNYTEFKFPQIKAHPWT 302 +F + L + ++LG IR + + N + ++ + P Sbjct: 253 LFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLR 312 Query: 303 KVFRPRTPP--EAIALCSRLLEYTPTARLTPLEACAHSFFDELRD--PNVKLPNGRD 355 + + L +LEY P RLT EA H FF LR PN + RD Sbjct: 313 RYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRD 369 >5UUU-A nrPDB Length = 547 Score = 78.6 bits (192), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 61/217 (28%), Positives = 109/217 (50%), Gaps = 31/217 (14%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRE-----------LQIMRKL 104 ++ ++IG G FG VY + D+G++ A+K L KR K ++ L ++ Sbjct: 200 FSVHRIIGRGGFGEVYGCRKADTGKMYAMK-CLDKKRIKMKQGETLALNERIMLSLVSTG 258 Query: 105 DHCNIVRLRYFFYSSGEKKDEVYLNLVLDYV--PETVYRVARH--YSRAKQTLPVIYVKL 160 D IV + Y F++ + L+ +LD + + Y +++H +S A ++ Sbjct: 259 DCPFIVCMSYAFHTPDK------LSFILDLMNGGDLHYHLSQHGVFSEAD-------MRF 305 Query: 161 YMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSR 220 Y ++ L ++H+ + +RD+KP N+LLD V ++ D G A + +P+ S + + Sbjct: 306 YAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHV-RISDLGLACDFSKKKPHAS-VGTH 363 Query: 221 YYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIF 257 Y APE++ Y SS D +S GC+L +LL G F Sbjct: 364 GYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPF 400 >4KIK-B nrPDB Length = 677 Score = 78.6 bits (192), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 62/206 (30%), Positives = 97/206 (47%), Gaps = 9/206 (4%) Query: 62 IGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRE-----LQIMRKLDHCNIVRLRYFF 116 +G G FG V + ++GE +AIK+ Q+ +NRE +QIMR+L H N+V R Sbjct: 27 LGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQIMRRLTHPNVVAARDVP 86 Query: 117 YSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFG 176 L ++Y R + L + + + +L Y+H Sbjct: 87 EGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALRYLHENR 146 Query: 177 ICHRDIKPQNLLLDPDTAVL--KLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDY 234 I HRD+KP+N++L L K+ D G AK+L +G S++ + Y APEL+ Y Sbjct: 147 IIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELL-EQQKY 205 Query: 235 TSSIDVWSAGCVLAELLLG-QPIFPG 259 T ++D WS G + E + G +P P Sbjct: 206 TVTVDYWSFGTLAFECITGFRPFLPN 231 >3COM-A nrPDB Length = 314 Score = 78.6 bits (192), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 62/210 (29%), Positives = 109/210 (51%), Gaps = 16/210 (7%) Query: 50 RPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN--RELQIMRKLDHC 107 +P+EV + + +G GS+G VY+A ++G++VAIK+V + + +E+ IM++ D Sbjct: 26 QPEEV-FDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEIIKEISIMQQCDSP 84 Query: 108 NIVRLRYFFYSSGEKKDEVYLNLVLDYV-PETVYRVARHYSRAKQTLPVIYVKLYMYQLF 166 ++V+ +Y S K +++ +V++Y +V + R ++ TL + + Sbjct: 85 HVVK----YYGSYFKNTDLW--IVMEYCGAGSVSDIIRLRNK---TLTEDEIATILQSTL 135 Query: 167 RSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRG-EPNVSYICSRYYRAP 225 + L Y+H HRDIK N+LL+ + KL DFG A QL + I + ++ AP Sbjct: 136 KGLEYLHFMRKIHRDIKAGNILLNTEGHA-KLADFGVAGQLTDTMAKRNTVIGTPFWMAP 194 Query: 226 ELIFGATDYTSSIDVWSAGCVLAELLLGQP 255 E+I Y D+WS G E+ G+P Sbjct: 195 EVI-QEIGYNCVADIWSLGITAIEMAEGKP 223 >5JZN-A nrPDB Length = 280 Score = 78.6 bits (192), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 82/279 (29%), Positives = 124/279 (44%), Gaps = 53/279 (18%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDK-----RFKNRELQIMRKLDHCNIV 110 Y + IG+G+F VV + + A+K + + K E+ I+R++ H NIV Sbjct: 21 YKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHMIQNEVSILRRVKHPNIV 80 Query: 111 RLRYFFYSSGEKKD---EVYLNLVLDYVP-----ETVYRVARHYSRAKQTLPVIYVKLYM 162 L E+ D E+YL V++ V + + ++ R + + Sbjct: 81 LLI-------EEMDVPTELYL--VMELVKGGDLFDAITSTNKYTERDASGM--------L 123 Query: 163 YQLFRSLAYIHSFGICHRDIKPQNLLL---DPDTAVLKLCDFGSAKQLVRGEPNVSYICS 219 Y L ++ Y+HS I HRDIKP+NLL+ + LKL DFG A +V G P + + Sbjct: 124 YNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLAT-IVDG-PLYTVCGT 181 Query: 220 RYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVL------ 273 Y APE+I T Y +D+W+AG + LL G P F G SG DQ V ++L Sbjct: 182 PTYVAPEII-AETGYGLKVDIWAAGVITYILLCGFPPFRG-SGDDQEVLFDQILMGQVDF 239 Query: 274 --------GTPTREQIREMNPNYTEFKFP--QIKAHPWT 302 +E I M + +F Q+ HPW Sbjct: 240 PSPYWDNVSDSAKELITMMLLVDVDQRFSAVQVLEHPWV 278 >2W1I-A nrPDB Length = 326 Score = 78.2 bits (191), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 64/206 (31%), Positives = 107/206 (51%), Gaps = 28/206 (13%) Query: 62 IGNGSFGVV----YQAKLCDSGELVAIKKVLQDK----RFKNRELQIMRKLDHCNIVRLR 113 +G G+FG V Y ++GE+VA+KK+ R RE++I++ L H NIV+ + Sbjct: 49 LGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYK 108 Query: 114 YFFYSSGEKKDEVYLNLVLDYVPETVYRVARHY-SRAKQTLPVIYVKLYMYQLFRSLAYI 172 YS+G + L L+++Y+P Y R Y + K+ + I + Y Q+ + + Y+ Sbjct: 109 GVCYSAGRRN----LKLIMEYLP---YGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYL 161 Query: 173 HSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRG-------EPNVSYICSRYYRAP 225 + HRD+ +N+L++ + V K+ DFG K L + EP S I ++ AP Sbjct: 162 GTKRYIHRDLATRNILVENENRV-KIGDFGLTKVLPQDKEYYKVKEPGESPI---FWYAP 217 Query: 226 ELIFGATDYTSSIDVWSAGCVLAELL 251 E + + ++ + DVWS G VL EL Sbjct: 218 ESL-TESKFSVASDVWSFGVVLYELF 242 >4APC-A nrPDB Length = 350 Score = 78.2 bits (191), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 66/226 (29%), Positives = 104/226 (46%), Gaps = 24/226 (10%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKV------LQDKRFKNRELQIMRKLDHCNI 109 Y + IG GSFG K + G IK++ +++ RE+ ++ + H NI Sbjct: 26 YVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKHPNI 85 Query: 110 VRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIY----VKLYMYQL 165 V+ R F +G L +V+DY + R V++ + + Q+ Sbjct: 86 VQYRESFEENGS------LYIVMDYCEG-----GDLFKRINAQKGVLFQEDQILDWFVQI 134 Query: 166 FRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRG-EPNVSYICSRYYRA 224 +L ++H I HRDIK QN+ L D V +L DFG A+ L E + I + YY + Sbjct: 135 CLALKHVHDRKILHRDIKSQNIFLTKDGTV-QLGDFGIARVLNSTVELARACIGTPYYLS 193 Query: 225 PELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEII 270 PE I Y + D+W+ GCVL EL + F S + +++II Sbjct: 194 PE-ICENKPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKII 238 >1FOT-A nrPDB Length = 318 Score = 78.2 bits (191), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 62/205 (30%), Positives = 102/205 (49%), Gaps = 28/205 (13%) Query: 60 KVIGNGSFGVVYQAKLCDSGELVAIKKV-------LQDKRFKNRELQIMRKLDHCNIVRL 112 + +G GSFG V+ + +G A+K + L+ N E ++ + H I+R+ Sbjct: 12 RTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTHPFIIRM 71 Query: 113 RYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYS--RAKQTLPVIYVKLYMYQLFRSLA 170 G +D + +++DY+ +S R Q P K Y ++ +L Sbjct: 72 ------WGTFQDAQQIFMIMDYI-----EGGELFSLLRKSQRFPNPVAKFYAAEVCLALE 120 Query: 171 YIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSY-ICSR-YYRAPELI 228 Y+HS I +RD+KP+N+LLD + + K+ DFG AK + P+V+Y +C Y APE++ Sbjct: 121 YLHSKDIIYRDLKPENILLDKNGHI-KITDFGFAKYV----PDVTYTLCGTPDYIAPEVV 175 Query: 229 FGATDYTSSIDVWSAGCVLAELLLG 253 Y SID WS G ++ E+L G Sbjct: 176 -STKPYNKSIDWWSFGILIYEMLAG 199 >3PVW-A nrPDB Length = 695 Score = 77.8 bits (190), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 61/217 (28%), Positives = 109/217 (50%), Gaps = 31/217 (14%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRE-----------LQIMRKL 104 ++ ++IG G FG VY + D+G++ A+K L KR K ++ L ++ Sbjct: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMK-CLDKKRIKMKQGETLALNERIMLSLVSTG 249 Query: 105 DHCNIVRLRYFFYSSGEKKDEVYLNLVLDYV--PETVYRVARH--YSRAKQTLPVIYVKL 160 D IV + Y F++ + L+ +LD + + Y +++H +S A ++ Sbjct: 250 DCPFIVCMSYAFHTPDK------LSFILDLMNGGDLHYHLSQHGVFSEAD-------MRF 296 Query: 161 YMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSR 220 Y ++ L ++H+ + +RD+KP N+LLD V ++ D G A + +P+ S + + Sbjct: 297 YAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHV-RISDLGLACDFSKKKPHAS-VGTH 354 Query: 221 YYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIF 257 Y APE++ Y SS D +S GC+L +LL G F Sbjct: 355 GYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPF 391 >5VO2-A nrPDB Length = 300 Score = 77.8 bits (190), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 58/198 (29%), Positives = 101/198 (51%), Gaps = 18/198 (9%) Query: 58 DTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFY 117 D + +G+G+ G V+ + GE VA+KKV + K +++ +RKL H NI+ + Sbjct: 16 DLQWVGSGAQGAVFLGRF--HGEEVAVKKV---RDLKETDIKHLRKLKHPNIITFK---- 66 Query: 118 SSGEKKDEVYLNLVLDYVPE-TVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFG 176 G +++++ + +Y V R + P + V M + + Y+H Sbjct: 67 --GVCTQAPCYCILMEFCAQGQLYEVLR---AGRPVTPSLLVDWSM-GIAGGMNYLHLHK 120 Query: 177 ICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTS 236 I HRD+K N+L+ D V+K+ DFG++K+L +S+ + + APE+I + Sbjct: 121 IIHRDLKSPNMLITYDD-VVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEP-VSE 178 Query: 237 SIDVWSAGCVLAELLLGQ 254 +D+WS G VL ELL G+ Sbjct: 179 KVDIWSFGVVLWELLTGE 196 >2OU7-A nrPDB Length = 335 Score = 77.8 bits (190), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 82/340 (24%), Positives = 132/340 (38%), Gaps = 70/340 (20%) Query: 62 IGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFK-------NRELQIMRKLDHCNIVRLRY 114 +G G F ++ D+ E+ A K V + K + E+ I R L H ++V Sbjct: 49 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 108 Query: 115 FFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHS 174 FF E D V++ L L R + ++ L + Y+ Q+ Y+H Sbjct: 109 FF----EDNDFVFVVLEL-----CRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHR 159 Query: 175 FGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSR-YYRAPELIFGATD 233 + HRD+K NL L+ D V K+ DFG A ++ +C Y APE + Sbjct: 160 NRVIHRDLKLGNLFLNEDLEV-KIGDFGLATKVEYDGERKKVLCGTPNYIAPE-VLSKKG 217 Query: 234 YTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKF 293 ++ +DVWS GC++ LL+G+P F + + I K E+ Sbjct: 218 HSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKK-----------------NEYSI 260 Query: 294 PQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNG 353 P+ P A +L ++L+ PTAR T E F Sbjct: 261 PK------------HINPVAASLIQKMLQTDPTARPTINELLNDEF-------------- 294 Query: 354 RDTPALFNFTTQELSSNPPLATILIPPHARIQAAASPPAN 393 FT+ + + P+ + IPP I ++ P+N Sbjct: 295 --------FTSGYIPARLPITCLTIPPRFSIAPSSLDPSN 326 >4OLI-A nrPDB Length = 645 Score = 77.8 bits (190), Expect = 9e-15, Method: Compositional matrix adjust. Identities = 70/208 (33%), Positives = 100/208 (48%), Gaps = 33/208 (15%) Query: 62 IGNGSFGVV----YQAKLCDSGELVAIKKVLQDKRFKNR-----ELQIMRKLDHCNIVRL 112 +G G FG V Y +GE+VA+K + D ++R E+ I+R L H +I++ Sbjct: 361 LGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKY 420 Query: 113 RYFFYSSGEKKDEVYLNLVLDYVPETVYR--VARHYSRAKQTLPVIYVKLYMYQLFRSLA 170 + GEK L LV++YVP R + RH Q L L+ Q+ +A Sbjct: 421 KGCCEDQGEKS----LQLVMEYVPLGSLRDYLPRHSIGLAQLL------LFAQQICEGMA 470 Query: 171 YIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSR-------YYR 223 Y+HS HR++ +N+LLD D V K+ DFG AK + G Y R ++ Sbjct: 471 YLHSQHYIHRNLAARNVLLDNDRLV-KIGDFGLAKAVPEGH---EYYRVREDGDSPVFWY 526 Query: 224 APELIFGATDYTSSIDVWSAGCVLAELL 251 APE + Y +S DVWS G L ELL Sbjct: 527 APECLKEYKFYYAS-DVWSFGVTLYELL 553 Score = 35.0 bits (79), Expect = 0.066, Method: Compositional matrix adjust. Identities = 27/110 (24%), Positives = 52/110 (47%), Gaps = 10/110 (9%) Query: 148 RAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLL------DPDTAVLKLCDF 201 R + +P+ + + QL +L+Y+ + + H ++ +N+LL + + +KL D Sbjct: 159 RERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDP 218 Query: 202 GSAKQLVRGEPNVSYICSRYYRAPELI-FGATDYTSSIDVWSAGCVLAEL 250 G + E V I + APE + GA ++++D W G L E+ Sbjct: 219 GVGLGALSREERVERIP---WLAPECLPGGANSLSTAMDKWGFGATLLEI 265 >3IO7-A nrPDB Length = 313 Score = 77.4 bits (189), Expect = 9e-15, Method: Compositional matrix adjust. Identities = 64/206 (31%), Positives = 107/206 (51%), Gaps = 28/206 (13%) Query: 62 IGNGSFGVV----YQAKLCDSGELVAIKKVLQDK----RFKNRELQIMRKLDHCNIVRLR 113 +G G+FG V Y ++GE+VA+KK+ R RE++I++ L H NIV+ + Sbjct: 36 LGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYK 95 Query: 114 YFFYSSGEKKDEVYLNLVLDYVPETVYRVARHY-SRAKQTLPVIYVKLYMYQLFRSLAYI 172 YS+G + L L+++Y+P Y R Y + K+ + I + Y Q+ + + Y+ Sbjct: 96 GVCYSAGRRN----LKLIMEYLP---YGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYL 148 Query: 173 HSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRG-------EPNVSYICSRYYRAP 225 + HRD+ +N+L++ + V K+ DFG K L + EP S I ++ AP Sbjct: 149 GTKRYIHRDLATRNILVENENRV-KIGDFGLTKVLPQDKEYYKVKEPGESPI---FWYAP 204 Query: 226 ELIFGATDYTSSIDVWSAGCVLAELL 251 E + + ++ + DVWS G VL EL Sbjct: 205 ESL-TESKFSVASDVWSFGVVLYELF 229 >3RAW-A nrPDB Length = 381 Score = 77.4 bits (189), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 85/368 (23%), Positives = 145/368 (39%), Gaps = 68/368 (18%) Query: 19 QPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDS 78 Q S S V DK+G V + D QE Y +G G+FG V + Sbjct: 24 QSSKRSSRSVEDDKEGHLVCRI-------GDWLQE-RYEIVGNLGEGTFGKVVECLDHAR 75 Query: 79 GE----LVAIKKVLQDKRFKNRELQIMRKLDH--------CNIVRLRYFFYSSGEKKDEV 126 G+ L I+ V + + E+ +++K+ C ++ + F+ E+ Sbjct: 76 GKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFEL 135 Query: 127 YLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQN 186 +++ E + Q P+ +V+ YQL +L ++H + H D+KP+N Sbjct: 136 LGKNTFEFLKENNF----------QPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPEN 185 Query: 187 LLL------------------DPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELI 228 +L +++ DFGSA E + + + +R+YR PE+I Sbjct: 186 ILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSAT--FDHEHHTTIVATRHYRPPEVI 243 Query: 229 FGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIRE----- 283 + DVWS GC+L E G +F + LV + K+LG I Sbjct: 244 L-ELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQK 302 Query: 284 --------MNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIA---LCSRLLEYTPTARLTPL 332 + N ++ ++ + P K + + E + L R+LE+ P R+T Sbjct: 303 YFYKGGLVWDENSSDGRYVKENCKP-LKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLA 361 Query: 333 EACAHSFF 340 EA H FF Sbjct: 362 EALLHPFF 369 >4F9B-A nrPDB Length = 361 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 68/242 (28%), Positives = 102/242 (42%), Gaps = 57/242 (23%) Query: 158 VKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAK------------ 205 V+ YM LF++L IH FGI HRD+KP N L + L DFG A+ Sbjct: 119 VREYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKF 178 Query: 206 -----QLVRGEPNVSYIC-SRY-----------YRAPELIFGATDYTSSIDVWSAGCVLA 248 Q R N IC SR +RAPE++ + T++ID+WSAG + Sbjct: 179 VQSEAQQERCSQNKCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFL 238 Query: 249 ELLLGQ-PIFPGDSGVDQLVEIIKVLGT--------------------PTR------EQI 281 LL G+ P + + L +I+ + G+ P + E++ Sbjct: 239 SLLSGRYPFYKASDDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERL 298 Query: 282 REMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFD 341 R M+ + + I+ H P EA L +LL+ P +R+T EA H FF Sbjct: 299 RGMDSSTPKLT-SDIQGHATNLEGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFFK 357 Query: 342 EL 343 ++ Sbjct: 358 DM 359 >3EQC-A nrPDB Length = 360 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 63/209 (30%), Positives = 112/209 (53%), Gaps = 23/209 (11%) Query: 62 IGNGSFGVVYQAKLCDSGELVAIKKVLQDKR--FKN---RELQIMRKLDHCNIVRLRYFF 116 +G G+ GVV++ SG ++A K + + + +N RELQ++ + + IV F Sbjct: 41 LGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAF 100 Query: 117 YSSGEKKDEVYLNLVLDYVPE-TVYRVARHYSRA-KQTLPVIYVKLYMYQLFRSLAYI-H 173 YS GE +++ ++++ ++ +V + R +Q L + + + + L Y+ Sbjct: 101 YSDGE------ISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAV-----IKGLTYLRE 149 Query: 174 SFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATD 233 I HRD+KP N+L++ + KLCDFG + QL+ N S++ +R Y +PE + G T Sbjct: 150 KHKIMHRDVKPSNILVNSRGEI-KLCDFGVSGQLIDSMAN-SFVGTRSYMSPERLQG-TH 206 Query: 234 YTSSIDVWSAGCVLAELLLGQ-PIFPGDS 261 Y+ D+WS G L E+ +G+ PI P D+ Sbjct: 207 YSVQSDIWSMGLSLVEMAVGRYPIPPPDA 235 >3NYO-A nrPDB Length = 576 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 77/301 (25%), Positives = 132/301 (43%), Gaps = 46/301 (15%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ-------DKRFKNRELQIMRKLDHC 107 ++ +V+G G FG V ++ +G++ A KK+ + + E QI+ K++ Sbjct: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSR 244 Query: 108 NIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFR 167 +V L Y + E KD + L L L + + + Y + P Y ++ Sbjct: 245 FVVSLAYAY----ETKDALCLVLTLMNGGDLKFHI---YHMGQAGFPEARAVFYAAEICC 297 Query: 168 SLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPEL 227 L +H I +RD+KP+N+LLD D +++ D G A + G+ + + Y APE+ Sbjct: 298 GLEDLHRERIVYRDLKPENILLD-DHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEV 356 Query: 228 IFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPN 287 + YT S D W+ GC+L E++ GQ F + E+ ++ ++E+ Sbjct: 357 VKNER-YTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERL--------VKEVPEE 407 Query: 288 YTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARL-----TPLEACAHSFFDE 342 Y+E R P+A +LCS+LL P RL + E H F + Sbjct: 408 YSE-----------------RFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKK 450 Query: 343 L 343 L Sbjct: 451 L 451 >4GS6-A nrPDB Length = 315 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 82/287 (28%), Positives = 132/287 (45%), Gaps = 27/287 (9%) Query: 60 KVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN--RELQIMRKLDHCNIVRLRYFFY 117 +V+G G+FGVV +AK + VAIK++ + K EL+ + +++H NIV+L Sbjct: 15 EVVGRGAFGVVCKAKW--RAKDVAIKQIESESERKAFIVELRQLSRVNHPNIVKLY---- 68 Query: 118 SSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSF-- 175 G + V LV++Y H + + + Q + +AY+HS Sbjct: 69 --GACLNPV--CLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQP 124 Query: 176 -GICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDY 234 + HRD+KP NLLL VLK+CDFG+A + N S + APE +F ++Y Sbjct: 125 KALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNK--GSAAWMAPE-VFEGSNY 181 Query: 235 TSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFP 294 + DV+S G +L E++ + F G I+ + TR + + P E Sbjct: 182 SEKCDVFSWGIILWEVITRRKPFDEIGG--PAFRIMWAVHNGTRPPLIKNLPKPIE---- 235 Query: 295 QIKAHPWTKVFRPR-TPPEAIALCSRLLEYTPTARLTPLE-ACAHSF 339 + W+K R + E + + + L+ Y P A PL+ C HS Sbjct: 236 SLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGAD-EPLQYPCQHSL 281 >5LOH-A nrPDB Length = 341 Score = 76.6 bits (187), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 65/221 (29%), Positives = 105/221 (47%), Gaps = 21/221 (9%) Query: 48 PDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ-DKRFKNRELQIMRKLDH 106 P P ++ K I G+FG VY + G+L A+K V + D KN Q+ + D Sbjct: 30 PKPPSIEEFSIVKPISRGAFGKVYLGQ--KGGKLYAVKVVKKADMINKNMTHQVQAERDA 87 Query: 107 CNIVRLRYF--FYSSGEKKDEVYLNLVLDYVPETVYRVARH-YSRAKQTLPVIYVKLYMY 163 + + + Y S + + VYL V++Y+ + H Y + + V Y+ Sbjct: 88 LALSKSPFIVHLYYSLQSANNVYL--VMEYLIGGDVKSLLHIYGYFDEEMAVKYIS---- 141 Query: 164 QLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY-- 221 ++ +L Y+H GI HRD+KP N+L+ + +KL DFG +K + + N+ I + Sbjct: 142 EVALALDYLHRHGIIHRDLKPDNMLIS-NEGHIKLTDFGLSKVTLNRDINMMDILTTRTF 200 Query: 222 -----YRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIF 257 Y APEL+ G + ++D W+ G L E L G P F Sbjct: 201 CGTPDYLAPELLLGRA-HGPAVDWWALGVCLFEFLTGIPPF 240 >3SOA-A nrPDB Length = 444 Score = 76.3 bits (186), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 83/294 (28%), Positives = 127/294 (43%), Gaps = 56/294 (19%) Query: 62 IGNGSFGVVYQAKLCDSGE-----LVAIKKV-LQDKRFKNRELQIMRKLDHCNIVRLRYF 115 +G G+F VV + +G+ ++ KK+ +D + RE +I R L H NIVRL Sbjct: 19 LGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDHQKLEREARICRLLKHPNIVRLH-- 76 Query: 116 FYSSGEKKDEVYLNLVLDYVP-----ETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLA 170 +E + L+ D V E + VAR Y I Q+ ++ Sbjct: 77 ----DSISEEGHHYLIFDLVTGGELFEDI--VAREYYSEADASHCIQ------QILEAVL 124 Query: 171 YIHSFGICHRDIKPQNLLLDPDT--AVLKLCDFGSAKQLVRGEPNV--SYICSRYYRAPE 226 + H G+ HR++KP+NLLL A +KL DFG A + V GE + + Y +PE Sbjct: 125 HCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIE-VEGEQQAWFGFAGTPGYLSPE 183 Query: 227 LIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNP 286 + Y +D+W+ G +L LL+G P F D +L + IK Sbjct: 184 -VLRKDPYGKPVDLWACGVILYILLVGYPPF-WDEDQHRLYQQIKA-------------- 227 Query: 287 NYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF 340 + FP + W V PEA L +++L P+ R+T EA H + Sbjct: 228 --GAYDFPSPE---WDTV-----TPEAKDLINKMLTINPSKRITAAEALKHPWI 271 >4HVI-A nrPDB Length = 314 Score = 75.9 bits (185), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 68/210 (32%), Positives = 104/210 (49%), Gaps = 36/210 (17%) Query: 62 IGNGSFGVVYQAKLC-------DSGELVAIKKVLQ----DKRFKNRELQIMRKLDHCNIV 110 +G G+FG V +LC ++G LVA+K++ +R RE+QI++ L IV Sbjct: 18 LGKGNFGSV---ELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIV 74 Query: 111 RLRYFFYSSGEKKDEVYLNLVLDYVPETVYR--VARHYSRAKQTLPVIYVKLYMYQLFRS 168 + R Y G + L LV++Y+P R + RH +R L + LY Q+ + Sbjct: 75 KYRGVSYGPGRQS----LRLVMEYLPSGCLRDFLQRHRAR----LDASRLLLYSSQICKG 126 Query: 169 LAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQL-------VRGEPNVSYICSRY 221 + Y+ S HRD+ +N+L++ + V K+ DFG AK L V EP S I + Sbjct: 127 MEYLGSRRCVHRDLAARNILVESEAHV-KIADFGLAKLLPLDKDYYVVREPGQSPI---F 182 Query: 222 YRAPELIFGATDYTSSIDVWSAGCVLAELL 251 + APE + ++ DVWS G VL EL Sbjct: 183 WYAPESL-SDNIFSRQSDVWSFGVVLYELF 211 >6DBM-A nrPDB Length = 318 Score = 75.9 bits (185), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 73/227 (32%), Positives = 104/227 (45%), Gaps = 36/227 (15%) Query: 46 QGPDRP---QEVSYTDTKVIGNGSFGVV----YQAKLCDSGELVAIKKVLQDKRFKNR-- 96 QGP P + + +G G FG V Y +GE+VA+K + D ++R Sbjct: 20 QGPGDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAGPQHRSG 79 Query: 97 ---ELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYR--VARHYSRAKQ 151 E+ I+R L H +I++ + E L LV++YVP R + RH Q Sbjct: 80 WKQEIDILRTLYHEHIIKYK----GCCEDAGAASLQLVMEYVPLGSLRDYLPRHSIGLAQ 135 Query: 152 TLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGE 211 L L+ Q+ +AY+HS HRD+ +N+LLD D V K+ DFG AK + G Sbjct: 136 LL------LFAQQICEGMAYLHSQHYIHRDLAARNVLLDNDRLV-KIGDFGLAKAVPEGH 188 Query: 212 PNVSYICSR-------YYRAPELIFGATDYTSSIDVWSAGCVLAELL 251 Y R ++ APE + Y +S DVWS G L ELL Sbjct: 189 ---EYYRVREDGDSPVFWYAPECLKEYKFYYAS-DVWSFGVTLYELL 231 >3Q53-A nrPDB Length = 306 Score = 75.9 bits (185), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 68/248 (27%), Positives = 119/248 (47%), Gaps = 32/248 (12%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKV-LQD---KRFKNRELQIMRKLDHCNIVR 111 YT + IG G+ G VY A +G+ VAI+++ LQ K E+ +MR+ + NIV Sbjct: 23 YTRFEKIGQGASGTVYTAMDVATGQEVAIRQMNLQQQPKKELIINEILVMRENKNPNIVN 82 Query: 112 LRYFFYSSGEKKDEVYLNL-------VLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQ 164 + S DE+++ + + D V ET + + ++ L Sbjct: 83 ----YLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECL----------- 127 Query: 165 LFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSR-YYR 223 ++L ++HS + HRDIK N+LL D +V KL DFG Q+ + S + Y+ Sbjct: 128 --QALEFLHSNQVIHRDIKSDNILLGMDGSV-KLTDFGFCAQITPEQSKRSTMVGTPYWM 184 Query: 224 APELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIRE 283 APE++ Y +D+WS G + E++ G+P + ++ + L +I GTP + + Sbjct: 185 APEVVTRKA-YGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALY-LIATNGTPELQNPEK 242 Query: 284 MNPNYTEF 291 ++ + +F Sbjct: 243 LSAIFRDF 250 >5DYK-A nrPDB Length = 853 Score = 75.5 bits (184), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 86/327 (26%), Positives = 145/327 (44%), Gaps = 65/327 (19%) Query: 60 KVIGNGSFGVVYQA-----KLCDSGELVAIKKVLQDKRFKNRELQ--IMRKLDHCNIVRL 112 ++IG G+FG V K+ + + V+ + ++ + N +L+ I + DH I+RL Sbjct: 545 RIIGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLNQQNNIKLEREITAENDHPFIIRL 604 Query: 113 RYFFYSSGEKKDEVYLNLVLDYVPE-TVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAY 171 F KD Y + + V +Y R ++ + Y+ + ++ Y Sbjct: 605 VRTF------KDSKYFYFLTELVTGGELYDAIRKLGLLSKS----QAQFYLGSIILAIEY 654 Query: 172 IHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGA 231 +H I +RD+KP+N+LLD V KL DFG AK+ V+G + + + +Y APE+I G Sbjct: 655 LHERNIVYRDLKPENILLDKQGYV-KLIDFGCAKK-VQGRA-YTLVGTPHYMAPEVILGK 711 Query: 232 TDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEF 291 Y ++D+W+ G L E + G P+ G+ DQL EI + + T + Sbjct: 712 G-YGCTVDIWALGICLYEFICG-PLPFGNDEEDQL-EIFRDILTG-------------QL 755 Query: 292 KFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLP 351 FP T ++I L RLL P R+ C+ + F +++D Sbjct: 756 TFPDY-----------VTDTDSINLMKRLLCRLPQGRI----GCSINGFKDIKDH----- 795 Query: 352 NGRDTPALFNFTTQELSS---NPPLAT 375 P NF +L+ +PPL + Sbjct: 796 -----PFFSNFNWDKLAGRLLDPPLVS 817 >4EQM-A nrPDB Length = 294 Score = 75.5 bits (184), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 68/215 (31%), Positives = 105/215 (48%), Gaps = 28/215 (13%) Query: 62 IGNGSFGVVYQAKLCDSGELVAIKKVL--------QDKRFKNRELQIMRKLDHCNIVRLR 113 +G G VY A+ VAIK + KRF+ RE+ +L H NIV + Sbjct: 19 LGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETLKRFE-REVHNSSQLSHQNIVSM- 76 Query: 114 YFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIH 173 +++D+ Y LV++Y+ Y + L V + Q+ + + H Sbjct: 77 ----IDVDEEDDCYY-LVMEYIEGPTLS---EYIESHGPLSVDTAINFTNQILDGIKHAH 128 Query: 174 SFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVS----YICSRYYRAPELIF 229 I HRDIKPQN+L+D + LK+ DFG AK L E +++ + + Y +PE Sbjct: 129 DMRIVHRDIKPQNILIDSNKT-LKIFDFGIAKAL--SETSLTQTNHVLGTVQYFSPEQAK 185 Query: 230 G-ATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGV 263 G ATD + D++S G VL E+L+G+P F G++ V Sbjct: 186 GEATDECT--DIYSIGIVLYEMLVGEPPFNGETAV 218 >4J52-A nrPDB Length = 293 Score = 75.5 bits (184), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 77/295 (26%), Positives = 119/295 (40%), Gaps = 64/295 (21%) Query: 62 IGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFK-------NRELQIMRKLDHCNIVRLRY 114 +G G F ++ D+ E+ A K V + K + E+ I R L H ++V Sbjct: 22 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 81 Query: 115 FFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHS 174 FF E D V++ L L R + ++ L + Y+ Q+ Y+H Sbjct: 82 FF----EDNDFVFVVLEL-----CRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHR 132 Query: 175 FGICHRDIKPQNLLLDPDTAVLKLCDFGSA---------KQLVRGEPNVSYICSRYYRAP 225 + HRD+K NL L+ D V K+ DFG A K+++ G PN Y AP Sbjct: 133 NRVIHRDLKLGNLFLNEDLEV-KIGDFGLATKVEYDGERKKVLCGTPN--------YIAP 183 Query: 226 ELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMN 285 E + ++ +DVWS GC++ LL+G+P F + + I K Sbjct: 184 E-VLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKK-------------- 228 Query: 286 PNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF 340 E+ P+ P A +L ++L+ PTAR T E FF Sbjct: 229 ---NEYSIPK------------HINPVAASLIQKMLQTDPTARPTINELLNDEFF 268 >3PFQ-A nrPDB Length = 674 Score = 75.1 bits (183), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 91/366 (24%), Positives = 150/366 (40%), Gaps = 83/366 (22%) Query: 49 DRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCN 108 DR + + V+G GSFG V ++ + EL A+K + +D ++ +++ C Sbjct: 336 DRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVE-------CT 388 Query: 109 IVRLRYF-----------FYSSGEKKDEVYLNLVLDYV--PETVYRVARHYSRAKQTLPV 155 +V R +S + D +Y V++YV + +Y + + R K+ V Sbjct: 389 MVEKRVLALPGKPPFLTQLHSCFQTMDRLYF--VMEYVNGGDLMYHI-QQVGRFKEPHAV 445 Query: 156 IYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVS 215 Y LF ++ S GI +RD+K N++LD + + K+ DFG K+ + Sbjct: 446 FYAAEIAIGLF----FLQSKGIIYRDLKLDNVMLDSEGHI-KIADFGMCKENIWDGVTTK 500 Query: 216 YICSR-YYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLG 274 C Y APE+I Y S+D W+ G +L E+L GQ F G+ D+L Sbjct: 501 TFCGTPDYIAPEII-AYQPYGKSVDWWAFGVLLYEMLAGQAPFEGED-EDELF------- 551 Query: 275 TPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRT-PPEAIALCSRLLEYTPTARL---- 329 + I E N Y P++ EA+A+C L+ P RL Sbjct: 552 ----QSIMEHNVAY------------------PKSMSKEAVAICKGLMTKHPGKRLGCGP 589 Query: 330 -TPLEACAHSFF----------DELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILI 378 + H+FF E++ P +GR+ F T+ +PP +L Sbjct: 590 EGERDIKEHAFFRYIDWEKLERKEIQPPYKPKASGRNAENFDRFFTR----HPP---VLT 642 Query: 379 PPHARI 384 PP + Sbjct: 643 PPDQEV 648 >6FD3-A nrPDB Length = 300 Score = 75.1 bits (183), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 73/277 (26%), Positives = 128/277 (46%), Gaps = 45/277 (16%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKV-LQD---KRFKNRELQIMRKLDHCNIVR 111 YT + IG G+ G VY A +G+ VAIK++ LQ K E+ +MR+ + NIV Sbjct: 24 YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVN 83 Query: 112 LRYFFYSSGEKKDEVYLNL-------VLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQ 164 + S DE+++ + + D V ET + + ++ L Sbjct: 84 ----YLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECL----------- 128 Query: 165 LFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVS-YICSRYYR 223 ++L ++HS + HRDIK N+LL D +V KL DFG Q+ + S + + Y+ Sbjct: 129 --QALDFLHSNQVIHRDIKSDNILLGMDGSV-KLTDFGFCAQITPEQSKRSTMVGTPYWM 185 Query: 224 APELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIRE 283 APE++ Y +D+WS G + E++ G+P + ++ + L +I GTP + Sbjct: 186 APEVVTRKA-YGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALY-LIATNGTPELQNPER 243 Query: 284 MNPNYTEF-------------KFPQIKAHPWTKVFRP 307 ++ + +F ++ HP+ K+ +P Sbjct: 244 LSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLDKP 280 >5VD3-A nrPDB Length = 311 Score = 75.1 bits (183), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 68/250 (27%), Positives = 113/250 (45%), Gaps = 38/250 (15%) Query: 35 SKVTTVVATPGQGPDRPQ---EVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVL--- 88 + + + +PG P RP+ + S+ +G+GS+G V++ + + G L A+K+ + Sbjct: 35 GEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPF 94 Query: 89 ---QDKRFKNRELQIMRKL-DHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVAR 144 +D+ K E+ K+ H VRL + E+ +YL L + + Sbjct: 95 RGPKDRARKLAEVGSHEKVGQHPCCVRLEQAW----EEGGILYLQTEL-----CGPSLQQ 145 Query: 145 HYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFG-- 202 H +LP V Y+ +LA++HS G+ H D+KP N+ L P KL DFG Sbjct: 146 HCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGP-RGRCKLGDFGLL 204 Query: 203 ------SAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPI 256 A ++ G+P Y APEL+ G+ Y ++ DV+S G + E+ + Sbjct: 205 VELGTAGAGEVQEGDPR--------YMAPELLQGS--YGTAADVFSLGLTILEVACNMEL 254 Query: 257 FPGDSGVDQL 266 G G QL Sbjct: 255 PHGGEGWQQL 264 >5TUR-A nrPDB Length = 404 Score = 75.1 bits (183), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 71/269 (26%), Positives = 121/269 (44%), Gaps = 26/269 (9%) Query: 51 PQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDK-----RFKN-----RELQI 100 P E Y ++G+G FG VY VAIK V +D+ N E+ + Sbjct: 124 PLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVL 183 Query: 101 MRKLDH--CNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYV 158 ++K+ ++RL +F E+ D L L PE V + + + L Sbjct: 184 LKKVSSGFSGVIRLLDWF----ERPDSFVLIL---ERPEPVQDLF-DFITERGALQEELA 235 Query: 159 KLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYIC 218 + + +Q+ ++ + H+ G+ HRDIK +N+L+D + LKL DFGS L++ + Sbjct: 236 RSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGA-LLKDTVYTDFDG 294 Query: 219 SRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQ-LVEIIKVLGTPT 277 +R Y PE I + S VWS G +L +++ G F D + + V + + + Sbjct: 295 TRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSEC 354 Query: 278 REQIR---EMNPNYTEFKFPQIKAHPWTK 303 + IR + P+ F +I+ HPW + Sbjct: 355 QHLIRWCLALRPS-DRPTFEEIQNHPWMQ 382 >3DAK-A nrPDB Length = 290 Score = 74.3 bits (181), Expect = 8e-14, Method: Compositional matrix adjust. Identities = 62/216 (28%), Positives = 100/216 (46%), Gaps = 27/216 (12%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN-----RELQIMRKLDHCNIV 110 Y +VIG+G+ VV A E VAIK++ +K + +E+Q M + H NIV Sbjct: 12 YELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHHPNIV 71 Query: 111 RLRYFFYSSGEKKDEVYLNL-------VLDYVPETVYRVARHYSRAKQTLPVIYVKLYMY 163 +Y+S KDE++L + VLD + V + H S L + + Sbjct: 72 S----YYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAK-GEHKS---GVLDESTIATILR 123 Query: 164 QLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFG------SAKQLVRGEPNVSYI 217 ++ L Y+H G HRD+K N+LL D +V ++ DFG + + R + +++ Sbjct: 124 EVLEGLEYLHKNGQIHRDVKAGNILLGEDGSV-QIADFGVSAFLATGGDITRNKVRKTFV 182 Query: 218 CSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLG 253 + + APE++ Y D+WS G EL G Sbjct: 183 GTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATG 218 >4TNB-A nrPDB Length = 590 Score = 74.3 bits (181), Expect = 8e-14, Method: Compositional matrix adjust. Identities = 75/308 (24%), Positives = 132/308 (42%), Gaps = 51/308 (16%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNR--------ELQIMRKLDH 106 ++ +V+G G FG V ++ +G++ A K+ L+ KR K R E QI+ K++ Sbjct: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKR-LEKKRIKKRKGESMALNEKQILEKVNS 243 Query: 107 CNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLF 166 +V L Y + E KD + L L + + + + Y+ Y ++ Sbjct: 244 QFVVNLAYAY----ETKDALCLVLTIMNGGDLKFHI---YNMGNPGFEEERALFYAAEIL 296 Query: 167 RSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPE 226 L +H +RD+KP+N+LLD D +++ D G A ++ G+ + + Y APE Sbjct: 297 CGLEDLHHENTVYRDLKPENILLD-DYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPE 355 Query: 227 LIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNP 286 + Y S D W GC++ E++ GQ F G +E+++ Sbjct: 356 -VLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRG-----------------RKEKVKREEV 397 Query: 287 NYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACA-----HSFFD 341 + + ++ +H +++ EA ++C LL RL E A H FF Sbjct: 398 DRRVLETEEVYSHKFSE--------EAKSICKMLLTKDAKQRLGCQEEEAAEVKRHPFF- 448 Query: 342 ELRDPNVK 349 R+ N K Sbjct: 449 --RNMNFK 454 >2JDO-A nrPDB Length = 342 Score = 74.3 bits (181), Expect = 8e-14, Method: Compositional matrix adjust. Identities = 74/297 (24%), Positives = 130/297 (43%), Gaps = 59/297 (19%) Query: 60 KVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNREL-------QIMRKLDHCNIVRL 112 K++G G+FG V + +G A+K + ++ E+ ++++ H + L Sbjct: 16 KLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTAL 75 Query: 113 RYFFYSSGEKKDEVYLNLVLDYV--PETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLA 170 +Y F + L V++Y E + ++R ++ + Y ++ +L Sbjct: 76 KYAFQTHDR------LCFVMEYANGGELFFHLSRERVFTEER-----ARFYGAEIVSALE 124 Query: 171 YIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSR-YYRAPELIF 229 Y+HS + +RDIK +NL+LD D + K+ DFG K+ + + C Y APE + Sbjct: 125 YLHSRDVVYRDIKLENLMLDKDGHI-KITDFGLCKEGISDGATMKTFCGTPEYLAPE-VL 182 Query: 230 GATDYTSSIDVWSAGCVLAELLLGQ-PIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNY 288 DY ++D W G V+ E++ G+ P + D ++L E+I + E+IR Sbjct: 183 EDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDH--ERLFELILM------EEIR------ 228 Query: 289 TEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARL-----TPLEACAHSFF 340 FP+ + PEA +L + LL+ P RL E H FF Sbjct: 229 ----FPRTLS------------PEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFF 269 >5HI2-A nrPDB Length = 283 Score = 73.9 bits (180), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 69/225 (30%), Positives = 107/225 (47%), Gaps = 39/225 (17%) Query: 62 IGNGSFGVVYQAKLCDSGELVAIKKVL--QDKRFKNRELQIMRKLDHCNIVRLRYFFYSS 119 IG+GSFG VY+ K VA+K + Q + FKN E+ ++RK H NI L + YS+ Sbjct: 28 IGSGSFGTVYKGKWHGD---VAVKMLTPQQLQAFKN-EVGVLRKTRHVNI--LLFMGYST 81 Query: 120 GEK---------KDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLA 170 + +Y +L + ET + + + A+QT R + Sbjct: 82 KPQLAIVTQWCEGSSLYHHL---HASETKFEMKKLIDIARQTA-------------RGMD 125 Query: 171 YIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSA--KQLVRGEPNVSYIC-SRYYRAPEL 227 Y+H+ I HRD+K N+ L D V K+ DFG A K G + S + APE+ Sbjct: 126 YLHAKSIIHRDLKSNNIFLHEDNTV-KIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEV 184 Query: 228 IF--GATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEII 270 I + Y+ DV++ G VL EL+ GQ + + DQ++E++ Sbjct: 185 IRMQDSNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEMV 229 >2I0E-A nrPDB Length = 353 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 77/296 (26%), Positives = 126/296 (42%), Gaps = 61/296 (20%) Query: 49 DRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCN 108 DR + + V+G GSFG V ++ + EL A+K + +D ++ +++ C Sbjct: 15 DRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVE-------CT 67 Query: 109 IVRLRYF-----------FYSSGEKKDEVYLNLVLDYV--PETVYRVARHYSRAKQTLPV 155 +V R +S + D +Y V++YV + +Y + + R K+ V Sbjct: 68 MVEKRVLALPGKPPFLTQLHSCFQTMDRLYF--VMEYVNGGDLMYHI-QQVGRFKEPHAV 124 Query: 156 IYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVS 215 Y LF ++ S GI +RD+K N++LD + + K+ DFG K+ + Sbjct: 125 FYAAEIAIGLF----FLQSKGIIYRDLKLDNVMLDSEGHI-KIADFGMCKENIWDGVTTK 179 Query: 216 YICSR-YYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLG 274 C Y APE+I Y S+D W+ G +L E+L GQ F G+ D+L Sbjct: 180 TFCGTPDYIAPEII-AYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDE-DELF------- 230 Query: 275 TPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRT-PPEAIALCSRLLEYTPTARL 329 + I E N Y P++ EA+A+C L+ P RL Sbjct: 231 ----QSIMEHNVAY------------------PKSMSKEAVAICKGLMTKHPGKRL 264 >4LG4-A nrPDB Length = 299 Score = 73.6 bits (179), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 62/211 (29%), Positives = 110/211 (52%), Gaps = 18/211 (8%) Query: 50 RPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN--RELQIMRKLDHC 107 +P+EV + + +G GS+G V++A +SG++VAIK+V + + +E+ IM++ D Sbjct: 8 QPEEV-FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDSP 66 Query: 108 NIVRLRYFFYSSGEKKDEVYLNLVLDYV-PETVYRVARHYSRAKQTLPVIYVKLYMYQLF 166 +V+ +Y S K +++ +V++Y +V + R ++ TL + + Sbjct: 67 YVVK----YYGSYFKNTDLW--IVMEYCGAGSVSDIIRLRNK---TLIEDEIATILKSTL 117 Query: 167 RSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQL--VRGEPNVSYICSRYYRA 224 + L Y+H HR+IK N+LL+ + KL DFG A QL + N + I + ++ A Sbjct: 118 KGLEYLHFMRKIHRNIKAGNILLNTEGHA-KLADFGVAGQLTDTMAKRN-TVIGTPFWMA 175 Query: 225 PELIFGATDYTSSIDVWSAGCVLAELLLGQP 255 PE+I Y D+WS G E+ G+P Sbjct: 176 PEVI-QEIGYNCVADIWSLGITSIEMAEGKP 205 >3ORP-A nrPDB Length = 311 Score = 73.6 bits (179), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 75/244 (30%), Positives = 110/244 (45%), Gaps = 33/244 (13%) Query: 34 GSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDK-- 91 GS +TT P DR Y +++G G V+ A+ VA+K + D Sbjct: 1 GSHMTT----PSHLSDR-----YELGEILGFGGMSEVHLARDLRDHRDVAVKVLRADLAR 51 Query: 92 ------RFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEV--YLNLVLDYVPETVYRVA 143 RF+ RE Q L+H IV + Y +GE + +V++YV R Sbjct: 52 DPSFYLRFR-REAQNAAALNHPAIVAV----YDTGEAETPAGPLPYIVMEYVDGVTLRDI 106 Query: 144 RHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGS 203 H I V + ++L + H GI HRD+KP N+++ AV K+ DFG Sbjct: 107 VHTEGPMTPKRAIEV---IADACQALNFSHQNGIIHRDVKPANIMISATNAV-KVMDFGI 162 Query: 204 AKQLVRGEPNVS----YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPG 259 A+ + +V+ I + Y +PE G + S DV+S GCVL E+L G+P F G Sbjct: 163 ARAIADSGNSVTQTAAVIGTAQYLSPEQARGDSVDARS-DVYSLGCVLYEVLTGEPPFTG 221 Query: 260 DSGV 263 DS V Sbjct: 222 DSPV 225 >2BUJ-A nrPDB Length = 317 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 63/216 (29%), Positives = 90/216 (41%), Gaps = 20/216 (9%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVL----QDKRFKNRELQIMRKLDHCNIVR 111 Y + +G G F V + G A+K++L QD+ RE + R +H NI+R Sbjct: 31 YLFIQKLGEGGFSYVDLVEGLHDGHFYALKRILCHEQQDREEAQREADMHRLFNHPNILR 90 Query: 112 LRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAY 171 L + K E +L L + T++ L + + + R L Sbjct: 91 LVAYCLRERGAKHEAWLLLPF-FKRGTLWNEIERLKDKGNFLTEDQILWLLLGICRGLEA 149 Query: 172 IHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQL---VRGEPNVSYI-------CSRY 221 IH+ G HRD+KP N+LL D L D GS Q V G + C+ Sbjct: 150 IHAKGYAHRDLKPTNILLG-DEGQPVLMDLGSMNQACIHVEGSRQALTLQDWAAQRCTIS 208 Query: 222 YRAPELIFGATDYT---SSIDVWSAGCVLAELLLGQ 254 YRAPEL F + DVWS GCVL ++ G+ Sbjct: 209 YRAPEL-FSVQSHCVIDERTDVWSLGCVLYAMMFGE 243 >4C59-A nrPDB Length = 340 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 67/224 (29%), Positives = 107/224 (47%), Gaps = 30/224 (13%) Query: 60 KVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNR----ELQIMRKLD-HCNIVRLRY 114 +V+ G F VY+A+ SG A+K++L ++ KNR E+ M+KL H NIV+ Sbjct: 33 RVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRAIIQEVCFMKKLSGHPNIVQFCS 92 Query: 115 FFYSSGEKKD---EVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAY 171 E+ D +L L + V + + SR + + +K++ YQ R++ + Sbjct: 93 AASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGPLSCDTV-LKIF-YQTCRAVQH 150 Query: 172 IHSFG--ICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSR--------- 220 +H I HRD+K +NLLL + +KLCDFGSA + P+ S+ R Sbjct: 151 MHRQKPPIIHRDLKVENLLLS-NQGTIKLCDFGSATT-ISHYPDYSWSAQRRALVEEEIT 208 Query: 221 -----YYRAPELIFGATDY--TSSIDVWSAGCVLAELLLGQPIF 257 YR PE+I +++ D+W+ GC+L L Q F Sbjct: 209 RNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPF 252 >4E20-A nrPDB Length = 290 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 69/208 (33%), Positives = 99/208 (47%), Gaps = 33/208 (15%) Query: 62 IGNGSFGVV----YQAKLCDSGELVAIKKVL-----QDKRFKNRELQIMRKLDHCNIVRL 112 +G G FG V Y +GE+VA+K + Q + RE++I+R L H +IV+ Sbjct: 16 LGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSGWQREIEILRTLYHEHIVKY 75 Query: 113 RYFFYSSGEKKDEVYLNLVLDYVPETVYR--VARHYSRAKQTLPVIYVKLYMYQLFRSLA 170 + GEK + LV++YVP R + RH Q L L+ Q+ +A Sbjct: 76 KGCCEDQGEKS----VQLVMEYVPLGSLRDYLPRHCVGLAQLL------LFAQQICEGMA 125 Query: 171 YIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSR-------YYR 223 Y+H+ HR + +N+LLD D V K+ DFG AK + G Y R ++ Sbjct: 126 YLHAQHYIHRALAARNVLLDNDRLV-KIGDFGLAKAVPEGH---EYYRVREDGDSPVFWY 181 Query: 224 APELIFGATDYTSSIDVWSAGCVLAELL 251 APE + Y +S DVWS G L ELL Sbjct: 182 APECLKECKFYYAS-DVWSFGVTLYELL 208 >6AO5-A nrPDB Length = 362 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 61/210 (29%), Positives = 108/210 (51%), Gaps = 16/210 (7%) Query: 50 RPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN--RELQIMRKLDHC 107 +P+EV + + +G GS+G V++A +SG++VAIK+V + + +E+ IM++ D Sbjct: 7 QPEEV-FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDSP 65 Query: 108 NIVRLRYFFYSSGEKKDEVYLNLVLDYV-PETVYRVARHYSRAKQTLPVIYVKLYMYQLF 166 +V+ +Y S K +++ +V++Y +V + R ++ TL + + Sbjct: 66 YVVK----YYGSYFKNTDLW--IVMEYCGAGSVSDIIRLRNK---TLIEDEIATILKSTL 116 Query: 167 RSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNV-SYICSRYYRAP 225 + L Y+H HR+IK N+LL+ + KL DFG A QL + I + ++ AP Sbjct: 117 KGLEYLHFMRKIHRNIKAGNILLNTEGHA-KLADFGVAGQLTDTMAKRNTVIGTPFWMAP 175 Query: 226 ELIFGATDYTSSIDVWSAGCVLAELLLGQP 255 E+I Y D+WS G E+ G+P Sbjct: 176 EVI-QEIGYNCVADIWSLGITSIEMAEGKP 204 >4EUU-A nrPDB Length = 319 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 55/206 (26%), Positives = 103/206 (50%), Gaps = 23/206 (11%) Query: 59 TKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRF------KNRELQIMRKLDHCNIVRL 112 + ++G G+ V++ + +G+L AIK V + F + RE ++++KL+H NIV+L Sbjct: 14 SDILGQGATANVFRGRHKKTGDLFAIK-VFNNISFLRPVDVQMREFEVLKKLNHKNIVKL 72 Query: 113 RYFFYSSGEKKDEVYLNLVLDYVP-ETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAY 171 ++ E+ + L++++ P ++Y V S A LP + + + + + Sbjct: 73 ----FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNA-YGLPESEFLIVLRDVVGGMNH 127 Query: 172 IHSFGICHRDIKPQNLLL---DPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELI 228 + GI HR+IKP N++ + +V KL DFG+A++L E VS + Y P++ Sbjct: 128 LRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMY 187 Query: 229 FGAT-------DYTSSIDVWSAGCVL 247 A Y +++D+WS G Sbjct: 188 ERAVLRKDHQKKYGATVDLWSIGVTF 213 >4AN9-A nrPDB Length = 301 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 58/201 (28%), Positives = 106/201 (52%), Gaps = 22/201 (10%) Query: 62 IGNGSFGVVYQAKLCDSGELVAIKKVLQDKR--FKN---RELQIMRKLDHCNIVRLRYFF 116 +G G+ GVV++ SG ++A K + + + +N RELQ++ + + IV F Sbjct: 17 LGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAF 76 Query: 117 YSSGEKKDEVYLNLVLDYVPE-TVYRVARHYSRA-KQTLPVIYVKLYMYQLFRSLAYI-H 173 YS GE +++ ++++ ++ +V + R +Q L + + + + L Y+ Sbjct: 77 YSDGE------ISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAV-----IKGLTYLRE 125 Query: 174 SFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATD 233 I HRD+KP N+L++ + KLCDFG + QL+ N ++ +R Y +PE + G T Sbjct: 126 KHKIMHRDVKPSNILVNSRGEI-KLCDFGVSGQLIDEMAN-EFVGTRSYMSPERLQG-TH 182 Query: 234 YTSSIDVWSAGCVLAELLLGQ 254 Y+ D+WS G L E+ +G+ Sbjct: 183 YSVQSDIWSMGLSLVEMAVGR 203 >2J90-A nrPDB Length = 304 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 80/312 (25%), Positives = 131/312 (41%), Gaps = 52/312 (16%) Query: 53 EVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN-----------RELQIM 101 E Y + +G+G F +V + + +G+ A K ++ +R + RE+ I+ Sbjct: 25 EDHYEMGEELGSGQFAIVRKCRQKGTGKEYA-AKFIKKRRLSSSRRGVSREEIEREVNIL 83 Query: 102 RKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLY 161 R++ H NI+ L F E K +V L L L E +A K++L + Sbjct: 84 REIRHPNIITLHDIF----ENKTDVVLILELVSGGELFDFLAE-----KESLTEDEATQF 134 Query: 162 MYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAV----LKLCDFGSAKQLVRGEPNVSYI 217 + Q+ + Y+HS I H D+KP+N++L D V +KL DFG A ++ G + Sbjct: 135 LKQILDGVHYLHSKRIAHFDLKPENIML-LDKNVPNPRIKLIDFGIAHKIEAGNEFKNIF 193 Query: 218 CSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPT 277 + + APE++ D+WS G + LL G F G++ + L I V Sbjct: 194 GTPEFVAPEIV-NYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAV----- 247 Query: 278 REQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAH 337 N ++ E F T A RLL P R+T ++ H Sbjct: 248 -------NYDFDEEYFSN-------------TSELAKDFIRRLLVKDPKRRMTIAQSLEH 287 Query: 338 SFFDELRDPNVK 349 S+ +R NV+ Sbjct: 288 SWIKAIRRRNVR 299 >4AW2-A nrPDB Length = 437 Score = 72.8 bits (177), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 63/224 (28%), Positives = 105/224 (46%), Gaps = 22/224 (9%) Query: 60 KVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKL-------DHCNIVRL 112 KVIG G+FG V KL ++ ++ A+K + + + K E R+ D I L Sbjct: 80 KVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDSKWITTL 139 Query: 113 RYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYI 172 Y F +D+ L LV+DY + S+ + LP + Y+ ++ ++ + Sbjct: 140 HYAF------QDDNNLYLVMDYYVGG--DLLTLLSKFEDRLPEEMARFYLAEMVIAIDSV 191 Query: 173 HSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYIC--SRYYRAPELI-- 228 H HRDIKP N+L+D + + +L DFGS +L+ S + + Y +PE++ Sbjct: 192 HQLHYVHRDIKPDNILMDMNGHI-RLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQA 250 Query: 229 --FGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEII 270 G Y D WS G + E+L G+ F +S V+ +I+ Sbjct: 251 MEGGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIM 294 >1ZXE-A nrPDB Length = 303 Score = 72.8 bits (177), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 68/250 (27%), Positives = 117/250 (46%), Gaps = 36/250 (14%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN---RELQIMRKLDHCNIVRL 112 + + V+G G+FG V +A+ AIKK+ + + E+ ++ L+H +VR Sbjct: 8 FEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRHTEEKLSTILSEVMLLASLNHQYVVRY 67 Query: 113 -------RYFFYSSGEKKDEVYLNLVLDYVPE-TVYRVARHYSRAKQTLPVIYVKLYMYQ 164 R F K + L + ++Y T+Y + + +Q Y +L+ Q Sbjct: 68 YAAWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQRDE--YWRLFR-Q 124 Query: 165 LFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVR--------------- 209 + +L+YIHS GI HR++KP N+ +D V K+ DFG AK + R Sbjct: 125 ILEALSYIHSQGIIHRNLKPMNIFIDESRNV-KIGDFGLAKNVHRSLDILKLDSQNLPGS 183 Query: 210 GEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEI 269 + S I + Y A E++ G Y ID++S G + E+ I+P +G+++ V I Sbjct: 184 SDNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEM-----IYPFSTGMER-VNI 237 Query: 270 IKVLGTPTRE 279 +K L + + E Sbjct: 238 LKKLRSVSIE 247 >3BGP-A nrPDB Length = 333 Score = 72.8 bits (177), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 76/287 (26%), Positives = 128/287 (44%), Gaps = 28/287 (9%) Query: 43 TPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNREL---- 98 PG+ + P E Y ++G+G FG VY VAIK V +D+ EL Sbjct: 46 APGKEKE-PLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGT 104 Query: 99 ------QIMRKLD--HCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAK 150 +++K+ ++RL +F E+ D L L PE V + + + Sbjct: 105 RVPMEVVLLKKVSSGFSGVIRLLDWF----ERPDSFVLIL---ERPEPVQDLFD-FITER 156 Query: 151 QTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRG 210 L + + +Q+ ++ + H+ G+ HRDIK +N+L+D + LKL DFGS L++ Sbjct: 157 GALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGA-LLKD 215 Query: 211 EPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQ-LVEI 269 + +R Y PE I + S VWS G +L +++ G F D + + V Sbjct: 216 TVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFF 275 Query: 270 IKVLGTPTREQIR---EMNPNYTEFKFPQIKAHPWTK-VFRPRTPPE 312 + + + + IR + P+ F +I+ HPW + V P+ E Sbjct: 276 RQRVSSECQHLIRWCLALRPS-DRPTFEEIQNHPWMQDVLLPQETAE 321 >3KN6-A nrPDB Length = 325 Score = 72.8 bits (177), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 60/209 (28%), Positives = 108/209 (51%), Gaps = 27/209 (12%) Query: 60 KVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFK---NRELQIMRKLD-HCNIVRLRYF 115 K +G GSF + + S + A+K + KR + +E+ ++ + H NIV+L Sbjct: 17 KPLGEGSFSICRKCVHKKSNQAFAVKII--SKRMEANTQKEITALKLCEGHPNIVKLHEV 74 Query: 116 FYSSGEKKDEVYLNLVLDYVP--ETVYRVAR--HYSRAKQTLPVIYVKLYMYQLFRSLAY 171 F+ D+++ LV++ + E R+ + H+S + + Y+ M +L ++++ Sbjct: 75 FH------DQLHTFLVMELLNGGELFERIKKKKHFSETEAS----YI---MRKLVSAVSH 121 Query: 172 IHSFGICHRDIKPQNLLL--DPDTAVLKLCDFGSAK-QLVRGEPNVSYICSRYYRAPELI 228 +H G+ HRD+KP+NLL + D +K+ DFG A+ + +P + + +Y APEL+ Sbjct: 122 MHDVGVVHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELL 181 Query: 229 FGATDYTSSIDVWSAGCVLAELLLGQPIF 257 Y S D+WS G +L +L GQ F Sbjct: 182 -NQNGYDESCDLWSLGVILYTMLSGQVPF 209 >4EUT-A nrPDB Length = 396 Score = 72.8 bits (177), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 55/206 (26%), Positives = 103/206 (50%), Gaps = 23/206 (11%) Query: 59 TKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRF------KNRELQIMRKLDHCNIVRL 112 + ++G G+ V++ + +G+L AIK V + F + RE ++++KL+H NIV+L Sbjct: 14 SDILGQGATANVFRGRHKKTGDLFAIK-VFNNISFLRPVDVQMREFEVLKKLNHKNIVKL 72 Query: 113 RYFFYSSGEKKDEVYLNLVLDYVP-ETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAY 171 ++ E+ + L++++ P ++Y V S A LP + + + + + Sbjct: 73 ----FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNA-YGLPESEFLIVLRDVVGGMNH 127 Query: 172 IHSFGICHRDIKPQNLLL---DPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELI 228 + GI HR+IKP N++ + +V KL DFG+A++L E VS + Y P++ Sbjct: 128 LRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMY 187 Query: 229 FGAT-------DYTSSIDVWSAGCVL 247 A Y +++D+WS G Sbjct: 188 ERAVLRKDHQKKYGATVDLWSIGVTF 213 >2UV2-A nrPDB Length = 325 Score = 72.8 bits (177), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 62/211 (29%), Positives = 100/211 (47%), Gaps = 34/211 (16%) Query: 62 IGNGSFGVVYQAKLCDSGELVAIKKV-------LQDKRFKNRELQIMRKLDHCNIVRLRY 114 +G+G+FG VY+A+ ++ L A K + L+D E+ I+ DH NIV+L Sbjct: 45 LGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMV---EIDILASCDHPNIVKLLD 101 Query: 115 FFYSSGEKKDEVYLNLVLDY-----VPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 169 FY E L +++++ V + + R + ++ +++ Q +L Sbjct: 102 AFYY------ENNLWILIEFCAGGAVDAVMLELERPLTESQ-------IQVVCKQTLDAL 148 Query: 170 AYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFG-SAKQLVRGEPNVSYICSRYYRAPELI 228 Y+H I HRD+K N+L D + KL DFG SAK + S+I + Y+ APE++ Sbjct: 149 NYLHDNKIIHRDLKAGNILFTLDGDI-KLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVV 207 Query: 229 FGATD----YTSSIDVWSAGCVLAELLLGQP 255 T Y DVWS G L E+ +P Sbjct: 208 MCETSKDRPYDYKADVWSLGITLIEMAEIEP 238 >4UYA-A nrPDB Length = 340 Score = 72.4 bits (176), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 65/222 (29%), Positives = 105/222 (47%), Gaps = 32/222 (14%) Query: 60 KVIGNGSFGVVYQAKLCDSGELVAIKKVLQD--------KRFKNRELQIMRKLDHCNIVR 111 ++IG G FG VY+A G+ VA+K QD RE ++ L H NI+ Sbjct: 32 ELIGAGGFGQVYRATW--QGQEVAVKAARQDPEQDAAAAAESVRREARLFAMLRHPNIIE 89 Query: 112 LRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAY 171 LR G + +L LVL++ A + + A + +P + + Q+ R + Y Sbjct: 90 LR------GVCLQQPHLCLVLEFARGG----ALNRALAGRRIPPHVLVNWAVQIARGMLY 139 Query: 172 IHSFG---ICHRDIKPQNLLL-------DPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY 221 +H I HRD+K N+LL D LK+ DFG A++ R ++ + Sbjct: 140 LHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHR-TTKMATAGAYA 198 Query: 222 YRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGV 263 + APE+I ++ ++ D+WS G +L ELL G+ + G G+ Sbjct: 199 WMAPEVI-KSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGL 239 >3TXO-A nrPDB Length = 353 Score = 72.4 bits (176), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 58/220 (26%), Positives = 112/220 (50%), Gaps = 21/220 (9%) Query: 60 KVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQ-IMRKLDHCNIVRLRYFF-- 116 +V+G GSFG V A++ ++G+L A+K + +D ++ +++ M + ++ R F Sbjct: 29 RVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQ 88 Query: 117 -YSSGEKKDEVYLNLVLDYV--PETVYRV--ARHYSRAKQTLPVIYVKLYMYQLFRSLAY 171 + + D ++ V+++V + ++ + +R + A+ + Y ++ +L + Sbjct: 89 LFCCFQTPDRLFF--VMEFVNGGDLMFHIQKSRRFDEAR-------ARFYAAEIISALMF 139 Query: 172 IHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ-LVRGEPNVSYICSRYYRAPELIFG 230 +H GI +RD+K N+LLD + KL DFG K+ + G ++ + Y APE I Sbjct: 140 LHDKGIIYRDLKLDNVLLDHEGHC-KLADFGMCKEGICNGVTTATFCGTPDYIAPE-ILQ 197 Query: 231 ATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEII 270 Y ++D W+ G +L E+L G F ++ D L E I Sbjct: 198 EMLYGPAVDWWAMGVLLYEMLCGHAPFEAENE-DDLFEAI 236 >3A8W-A nrPDB Length = 345 Score = 72.4 bits (176), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 58/209 (27%), Positives = 106/209 (50%), Gaps = 24/209 (11%) Query: 60 KVIGNGSFGVVYQAKLCDSGELVAIKKVL-------QDKRFKNRELQIMRKL-DHCNIVR 111 +VIG GS+ V +L + + A+K V +D + E + + +H +V Sbjct: 15 RVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVG 74 Query: 112 LRYFFYSSGEKKDEVYLNLVLDYV--PETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 169 L F + E L V++YV + ++ + R ++ LP + + Y ++ +L Sbjct: 75 LHSCFQT------ESRLFFVIEYVNGGDLMFHMQR-----QRKLPEEHARFYSAEISLAL 123 Query: 170 AYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVR-GEPNVSYICSRYYRAPELI 228 Y+H GI +RD+K N+LLD + + KL D+G K+ +R G+ ++ + Y APE++ Sbjct: 124 NYLHERGIIYRDLKLDNVLLDSEGHI-KLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEIL 182 Query: 229 FGATDYTSSIDVWSAGCVLAELLLGQPIF 257 G DY S+D W+ G ++ E++ G+ F Sbjct: 183 RGE-DYGFSVDWWALGVLMFEMMAGRSPF 210 >3DLS-A nrPDB Length = 335 Score = 72.4 bits (176), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 69/289 (23%), Positives = 130/289 (44%), Gaps = 42/289 (14%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIK-----KVLQDKRFKN-------RELQIMRK 103 Y+ +G+G+FG V+ A + + V +K KVL+D ++ E+ I+ + Sbjct: 26 YSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSR 85 Query: 104 LDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPE--TVYRVARHYSRAKQTLPVIYVKLY 161 ++H NI+++ F + G + LV++ ++ + R + L Y Sbjct: 86 VEHANIIKVLDIFENQG------FFQLVMEKHGSGLDLFAFIDRHPRLDEPLAS-----Y 134 Query: 162 MY-QLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSR 220 ++ QL ++ Y+ I HRDIK +N+++ D + KL DFGSA L RG+ ++ + Sbjct: 135 IFRQLVSAVGYLRLKDIIHRDIKDENIVIAEDFTI-KLIDFGSAAYLERGKLFYTFCGTI 193 Query: 221 YYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQ-PIFPGDSGVD-----------QLVE 268 Y APE++ G +++WS G L L+ + P + V+ +L+ Sbjct: 194 EYCAPEVLMGNPYRGPELEMWSLGVTLYTLVFEENPFCELEETVEAAIHPPYLVSKELMS 253 Query: 269 IIKVLGTPTREQIREMNPNYTEFKFPQ---IKAHPWTKVFRPRTPPEAI 314 ++ L P E+ + T+ Q + + W +VFR P + Sbjct: 254 LVSGLLQPVPERRTTLEKLVTDPWVTQPVNLADYTWEEVFRVNKPESGV 302 >2VD5-A nrPDB Length = 412 Score = 72.4 bits (176), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 63/237 (26%), Positives = 105/237 (44%), Gaps = 26/237 (10%) Query: 50 RPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKL----- 104 R Q + KVIG G+F V K+ +G++ A+K + + K E+ R+ Sbjct: 57 RLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLV 116 Query: 105 --DHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYM 162 D I +L + F +DE YL LV++Y + S+ + +P + Y+ Sbjct: 117 NGDRRWITQLHFAF------QDENYLYLVMEYYVGG--DLLTLLSKFGERIPAEMARFYL 168 Query: 163 YQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY- 221 ++ ++ +H G HRDIKP N+LLD ++L DFGS +L R + V + + Sbjct: 169 AEIVMAIDSVHRLGYVHRDIKPDNILLDR-CGHIRLADFGSCLKL-RADGTVRSLVAVGT 226 Query: 222 --YRAPELIFGATDYTS------SIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEII 270 Y +PE++ D W+ G E+ GQ F DS + +I+ Sbjct: 227 PDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIV 283 >3VN9-A nrPDB Length = 340 Score = 72.4 bits (176), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 72/289 (24%), Positives = 133/289 (46%), Gaps = 43/289 (14%) Query: 62 IGNGSFGVVYQAKLCDSGELVAIKKVL-----QDKRFKNRELQI-MRKLDHCNIVRLRYF 115 +G G++GVV + + SG+++A+K++ Q+++ +L I MR +D V Sbjct: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVT---- 114 Query: 116 FYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHS- 174 FY + ++ +V+ + ++ + ++ + + QT+P + + ++L ++HS Sbjct: 115 FYGALFREGDVW--ICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSK 172 Query: 175 FGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELI---FGA 231 + HRD+KP N+L++ +K+CDFG + LV + Y APE I Sbjct: 173 LSVIHRDVKPSNVLINA-LGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQ 231 Query: 232 TDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEF 291 Y+ D+WS G + EL + + FP DS GTP +Q++++ E Sbjct: 232 KGYSVKSDIWSLGITMIELAILR--FPYDS-----------WGTPF-QQLKQV----VEE 273 Query: 292 KFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF 340 PQ+ A ++ F + S+ L+ R T E H FF Sbjct: 274 PSPQLPADKFSAEF--------VDFTSQCLKKNSKERPTYPELMQHPFF 314 >4UY9-A nrPDB Length = 323 Score = 72.0 bits (175), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 71/226 (31%), Positives = 108/226 (47%), Gaps = 34/226 (15%) Query: 57 TDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQD------KRFKN--RELQIMRKLDHCN 108 T ++IG G FG VY+A G+ VA+K D + +N +E ++ L H N Sbjct: 12 TLEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPN 69 Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVPET-VYRVARHYSRAKQTLPVIYVKLYMYQLFR 167 I+ LR G E L LV+++ + RV K+ P I V + Q+ R Sbjct: 70 IIALR------GVCLKEPNLCLVMEFARGGPLNRVLS----GKRIPPDILVN-WAVQIAR 118 Query: 168 SLAYIHSFGIC---HRDIKPQNLLL-------DPDTAVLKLCDFGSAKQLVRGEPNVSYI 217 + Y+H I HRD+K N+L+ D +LK+ DFG A++ R +S Sbjct: 119 GMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHR-TTKMSAA 177 Query: 218 CSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGV 263 + + APE+I A+ ++ DVWS G +L ELL G+ F G G+ Sbjct: 178 GTYAWMAPEVI-RASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGL 222 >3H4J-B nrPDB Length = 336 Score = 72.0 bits (175), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 58/206 (28%), Positives = 99/206 (48%), Gaps = 18/206 (8%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN-------RELQIMRKLDHCN 108 Y + +G GSFG V A + + VA+K + + K+ RE+ ++ L H + Sbjct: 11 YIIRETLGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREISYLKLLRHPH 70 Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRS 168 I++L + + + +V++Y ++ Y K+ + + + Q+ + Sbjct: 71 IIKLYDVITTPTD------IVMVIEYAGGELF----DYIVEKKRMTEDEGRRFFQQIICA 120 Query: 169 LAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELI 228 + Y H I HRD+KP+NLLLD D +K+ DFG + + G + S Y APE+I Sbjct: 121 IEYCHRHKIVHRDLKPENLLLD-DNLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVI 179 Query: 229 FGATDYTSSIDVWSAGCVLAELLLGQ 254 G +DVWS G VL +L+G+ Sbjct: 180 NGKLYAGPEVDVWSCGIVLYVMLVGR 205 >4RC3-A nrPDB Length = 289 Score = 72.0 bits (175), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 72/276 (26%), Positives = 121/276 (43%), Gaps = 26/276 (9%) Query: 44 PGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNREL----- 98 P P E Y ++G+G FG VY VAIK V +D+ EL Sbjct: 2 PHMKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTR 61 Query: 99 -----QIMRKLD--HCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQ 151 +++K+ ++RL +F E+ D L L PE V + + + Sbjct: 62 VPMEVVLLKKVSSGFSGVIRLLDWF----ERPDSFVLIL---ERPEPVQDLF-DFITERG 113 Query: 152 TLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGE 211 L + + +Q+ ++ + H+ G+ HRDIK +N+L+D + LKL DFGS L++ Sbjct: 114 ALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGA-LLKDT 172 Query: 212 PNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQ-LVEII 270 + +R Y PE I + S VWS G +L +++ G F D + + V Sbjct: 173 VYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFR 232 Query: 271 KVLGTPTREQIR---EMNPNYTEFKFPQIKAHPWTK 303 + + + + IR + P+ F +I+ HPW + Sbjct: 233 QRVSSECQHLIRWCLALRPS-DRPTFEEIQNHPWMQ 267 >5KCV-A nrPDB Length = 460 Score = 72.0 bits (175), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 79/301 (26%), Positives = 129/301 (42%), Gaps = 66/301 (21%) Query: 60 KVIGNGSFGVVYQAKLCDSG----------ELVAIKKVLQDKRFKNRELQIMRKLDHCNI 109 K++G G+FG V K +G E++ K + +NR LQ R H + Sbjct: 168 KLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSR---HPFL 224 Query: 110 VRLRYFFYSSGEKKDEVYLNLVLDYV--PETVYRVARHYSRAKQTLPVIYVKLYMYQLFR 167 L+Y F + L V++Y E + ++R ++ + Y ++ Sbjct: 225 TALKYSFQTHDR------LCFVMEYANGGELFFHLSR-----ERVFSEDRARFYGAEIVS 273 Query: 168 SLAYIHSF-GICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSR-YYRAP 225 +L Y+HS + +RD+K +NL+LD D + K+ DFG K+ ++ + C Y AP Sbjct: 274 ALDYLHSEKNVVYRDLKLENLMLDKDGHI-KITDFGLCKEGIKDGATMKTFCGTPEYLAP 332 Query: 226 ELIFGATDYTSSIDVWSAGCVLAELLLGQ-PIFPGDSGVDQLVEIIKVLGTPTREQIREM 284 E + DY ++D W G V+ E++ G+ P + D ++L E+I + E+IR Sbjct: 333 E-VLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDH--EKLFELILM------EEIR-- 381 Query: 285 NPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARL-----TPLEACAHSF 339 FP+ PEA +L S LL+ P RL E H F Sbjct: 382 --------FPRTLG------------PEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRF 421 Query: 340 F 340 F Sbjct: 422 F 422 >6CCF-A nrPDB Length = 290 Score = 72.0 bits (175), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 65/228 (28%), Positives = 100/228 (43%), Gaps = 37/228 (16%) Query: 96 RELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNL-VLDYVPETVYRVARHYSRAKQTLP 154 +E+ I++KLDH N+V+L E D +YL +L P + +S + Sbjct: 77 QEIAILKKLDHVNVVKLIEVLDDPAE--DNLYLVFDLLRKGPVMEVPCDKPFSEEQ---- 130 Query: 155 VIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNV 214 +LY+ + L Y+H I HRDIKP NLLL D V K+ DFG + Q + + Sbjct: 131 ---ARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHV-KIADFGVSNQFEGNDAQL 186 Query: 215 SYICSR-YYRAPELI--FGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEII- 270 S + APE I G + ++DVW+ G L + G+ F +D + + Sbjct: 187 SSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPF-----IDDFILALH 241 Query: 271 -KVLGTPT--------REQIREM-------NPNYTEFKFPQIKAHPWT 302 K+ P E+++++ NP T P IK HPW Sbjct: 242 RKIKNEPVVFPEEPEISEELKDLILKMLDKNPE-TRIGVPDIKLHPWV 288 >3DTC-A nrPDB Length = 271 Score = 71.6 bits (174), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 71/226 (31%), Positives = 108/226 (47%), Gaps = 34/226 (15%) Query: 57 TDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQD------KRFKN--RELQIMRKLDHCN 108 T ++IG G FG VY+A G+ VA+K D + +N +E ++ L H N Sbjct: 10 TLEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPN 67 Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVPET-VYRVARHYSRAKQTLPVIYVKLYMYQLFR 167 I+ LR G E L LV+++ + RV K+ P I V + Q+ R Sbjct: 68 IIALR------GVCLKEPNLCLVMEFARGGPLNRVLS----GKRIPPDILVN-WAVQIAR 116 Query: 168 SLAYIHSFGIC---HRDIKPQNLLL-------DPDTAVLKLCDFGSAKQLVRGEPNVSYI 217 + Y+H I HRD+K N+L+ D +LK+ DFG A++ R +S Sbjct: 117 GMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHR-TTKMSAA 175 Query: 218 CSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGV 263 + + APE+I A+ ++ DVWS G +L ELL G+ F G G+ Sbjct: 176 GAYAWMAPEVI-RASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGL 220 >5DBX-A nrPDB Length = 328 Score = 71.6 bits (174), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 62/218 (28%), Positives = 103/218 (47%), Gaps = 29/218 (13%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCD-SGELVAIKKVLQDKRFKN-----RELQIMRKLDHCN 108 +Y +VIG+G+ VV QA LC E VAIK++ +K + +E+Q M + H N Sbjct: 12 AYELQEVIGSGATAVV-QAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQCSHPN 70 Query: 109 IVRLRYFFYSSGEKKDEVYLNL-------VLDYVPETVYRVARHYSRAKQTLPVIYVKLY 161 +V +Y+S KDE++L + +LD + V R ++ + +K Sbjct: 71 VVT----YYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILK-- 124 Query: 162 MYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFG------SAKQLVRGEPNVS 215 ++ L Y+H G HRD+K N+LL D +V ++ DFG + + R + Sbjct: 125 --EVLEGLDYLHRNGQIHRDLKAGNILLGEDGSV-QIADFGVSAFLATGGDVTRNKVRKD 181 Query: 216 YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLG 253 ++ + + APE++ Y D+WS G EL G Sbjct: 182 FVGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATG 219 >6BXI-A nrPDB Length = 333 Score = 71.6 bits (174), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 64/247 (25%), Positives = 103/247 (41%), Gaps = 58/247 (23%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNR-------ELQIMRKLDHCN 108 + KVIG G+FG V + D+G + A+K + + + E I+ + D Sbjct: 8 FESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADSLW 67 Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVP--ETVYRVARHYSRAKQTLPVIYVKLYMYQLF 166 +V++ Y F +D++ L L+++++P + + + + K TL + Y+ + Sbjct: 68 VVKMFYSF------QDKLNLYLIMEFLPGGDMMTLLMK-----KDTLTEEETQFYIAETV 116 Query: 167 RSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSY---------- 216 ++ IH G HRDIKP NLLLD V KL DFG L + Y Sbjct: 117 LAIDSIHQLGFIHRDIKPDNLLLDSKGHV-KLSDFGLCTGLKKAHRTEFYRNLNHSLPSD 175 Query: 217 --------------------------ICSRYYRAPELIFGATDYTSSIDVWSAGCVLAEL 250 + + Y APE +F T Y D WS G ++ E+ Sbjct: 176 FTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPE-VFMQTGYNKLCDWWSLGVIMYEM 234 Query: 251 LLGQPIF 257 L+G P F Sbjct: 235 LIGYPPF 241 >3FXW-A nrPDB Length = 336 Score = 71.6 bits (174), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 56/183 (30%), Positives = 87/183 (47%), Gaps = 25/183 (13%) Query: 162 MYQLFRSLAYIHSFGICHRDIKPQNLLL--DPDTAVLKLCDFGSAKQLVRGEPNVSYICS 219 M + ++ ++HS I HRD+KP+NLL AVLKL DFG AK+ + + Sbjct: 134 MRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNALQTP-CYT 192 Query: 220 RYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTRE 279 YY APE + G Y S D+WS G ++ LL G P F ++G + + + Sbjct: 193 PYYVAPE-VLGPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTG--------QAISPGMKR 243 Query: 280 QIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSF 339 +IR ++ FP + W++V +A L LL+ PT RLT + H + Sbjct: 244 RIR-----LGQYGFPNPE---WSEV-----SEDAKQLIRLLLKTDPTERLTITQFMNHPW 290 Query: 340 FDE 342 ++ Sbjct: 291 INQ 293 >4IDT-A nrPDB Length = 356 Score = 71.6 bits (174), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 60/213 (28%), Positives = 101/213 (47%), Gaps = 26/213 (12%) Query: 52 QEVSYTDTKV-IGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIV 110 +EV + ++ +G GSFG V++ + +G A+KKV + + F+ EL L IV Sbjct: 71 EEVHWATHQLRLGRGSFGEVHRMEDKQTGFQCAVKKV-RLEVFRAEELMACAGLTSPRIV 129 Query: 111 RLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLA 170 L G ++ ++N+ ++ + + + LP Y+ Q L Sbjct: 130 PL------YGAVREGPWVNIFMELLEGGSLG---QLVKEQGCLPEDRALYYLGQALEGLE 180 Query: 171 YIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSA---------KQLVRGEPNVSYI-CSR 220 Y+HS I H D+K N+LL D + LCDFG A K L+ G+ YI + Sbjct: 181 YLHSRRILHGDVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKDLLTGD----YIPGTE 236 Query: 221 YYRAPELIFGATDYTSSIDVWSAGCVLAELLLG 253 + APE++ G + + +DVWS+ C++ +L G Sbjct: 237 THMAPEVVLGRS-CDAKVDVWSSCCMMLHMLNG 268 >2HW6-A nrPDB Length = 307 Score = 71.6 bits (174), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 83/319 (26%), Positives = 136/319 (42%), Gaps = 58/319 (18%) Query: 48 PDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKV-LQDKRFKNRELQIMRKLDH 106 P + +++ ++++G G++ V A +G+ A+K + Q ++R + + L Sbjct: 7 PGKFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQ 66 Query: 107 C----NIVRLRYFFYSSGEKKDEVYLNL-------VLDYVPETVYRVARHYSRAKQTLPV 155 C NI+ L FF E YL +L ++ + + R SR + + Sbjct: 67 CQGNKNILELIEFF----EDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAA 122 Query: 156 IYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAV--LKLCDF--GSAKQLVRG- 210 +L ++H+ GI HRD+KP+N+L + V +K+CDF GS +L Sbjct: 123 ------------ALDFLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSC 170 Query: 211 ----EPNVSYIC-SRYYRAPELIFGATD----YTSSIDVWSAGCVLAELLLGQPIFPGDS 261 P ++ C S Y APE++ TD Y D+WS G VL +L G P F G Sbjct: 171 TPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHC 230 Query: 262 GVD---QLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCS 318 G D E+ +V E I+E +++FP W + EA L S Sbjct: 231 GADCGWDRGEVCRVCQNKLFESIQE-----GKYEFPD---KDWAHI-----SSEAKDLIS 277 Query: 319 RLLEYTPTARLTPLEACAH 337 +LL RL+ + H Sbjct: 278 KLLVRDAKQRLSAAQVLQH 296 >3MV5-A nrPDB Length = 342 Score = 71.6 bits (174), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 79/301 (26%), Positives = 129/301 (42%), Gaps = 66/301 (21%) Query: 60 KVIGNGSFGVVYQAKLCDSG----------ELVAIKKVLQDKRFKNRELQIMRKLDHCNI 109 K++G G+FG V K +G E++ K + +NR LQ R H + Sbjct: 16 KLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSR---HPFL 72 Query: 110 VRLRYFFYSSGEKKDEVYLNLVLDYV--PETVYRVARHYSRAKQTLPVIYVKLYMYQLFR 167 L+Y F + L V++Y E + ++R ++ + Y ++ Sbjct: 73 TALKYSFQTHDR------LCFVMEYANGGELFFHLSR-----ERVFSEDRARFYGAEIVS 121 Query: 168 SLAYIHSF-GICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSR-YYRAP 225 +L Y+HS + +RD+K +NL+LD D + K+ DFG K+ ++ + C Y AP Sbjct: 122 ALDYLHSEKNVVYRDLKLENLMLDKDGHI-KITDFGLCKEGIKDGATMKTFCGTPEYLAP 180 Query: 226 ELIFGATDYTSSIDVWSAGCVLAELLLGQ-PIFPGDSGVDQLVEIIKVLGTPTREQIREM 284 E + DY ++D W G V+ E++ G+ P + D ++L E+I + E+IR Sbjct: 181 E-VLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDH--EKLFELILM------EEIR-- 229 Query: 285 NPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARL-----TPLEACAHSF 339 FP+ PEA +L S LL+ P RL E H F Sbjct: 230 --------FPRTLG------------PEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRF 269 Query: 340 F 340 F Sbjct: 270 F 270 >4JLC-A nrPDB Length = 657 Score = 71.6 bits (174), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 55/203 (27%), Positives = 103/203 (50%), Gaps = 23/203 (11%) Query: 59 TKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRF------KNRELQIMRKLDHCNIVRL 112 + ++G G+ V++ + +G+L A+K V + F + RE ++++KL+H NIV+L Sbjct: 13 SDILGQGATANVFRGRHKKTGDLYAVK-VFNNISFLRPVDVQMREFEVLKKLNHKNIVKL 71 Query: 113 RYFFYSSGEKKDEVYLNLVLDYVP-ETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAY 171 ++ E+ + L++++ P ++Y V S A LP + + + + + Sbjct: 72 ----FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNA-YGLPESEFLIVLRDVVGGMNH 126 Query: 172 IHSFGICHRDIKPQNLLL---DPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELI 228 + GI HRDIKP N++ + +V KL DFG+A++L E VS + Y P++ Sbjct: 127 LRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMY 186 Query: 229 FGAT-------DYTSSIDVWSAG 244 A Y +++D+WS G Sbjct: 187 ERAVLRKDHQKKYGATVDLWSVG 209 >3TKU-A nrPDB Length = 433 Score = 71.6 bits (174), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 64/224 (28%), Positives = 103/224 (45%), Gaps = 22/224 (9%) Query: 60 KVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKL-------DHCNIVRL 112 KVIG G+FG V K+ ++ + A+K + + + K E R+ D I L Sbjct: 96 KVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDCQWITAL 155 Query: 113 RYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYI 172 Y F +DE +L LV+DY + S+ + LP + Y+ ++ ++ I Sbjct: 156 HYAF------QDENHLYLVMDYYVGG--DLLTLLSKFEDKLPEDMARFYIGEMVLAIDSI 207 Query: 173 HSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY--YRAPELIFG 230 H HRDIKP N+LLD + + +L DFGS ++ S + Y +PE++ Sbjct: 208 HQLHYVHRDIKPDNVLLDVNGHI-RLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQA 266 Query: 231 ATD----YTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEII 270 D Y D WS G + E+L G+ F +S V+ +I+ Sbjct: 267 MEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIM 310 >4CFF-A nrPDB Length = 571 Score = 71.2 bits (173), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 56/208 (26%), Positives = 98/208 (47%), Gaps = 23/208 (11%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN--------RELQIMRKLDHC 107 Y +G G+FG V + +G VA+K +L ++ ++ RE+Q ++ H Sbjct: 35 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVK-ILNRQKIRSLDVVGKIKREIQNLKLFRHP 93 Query: 108 NIVRLRYFFYSSGEKKDEVYLNLVLDYVP--ETVYRVARHYSRAKQTLPVIYVKLYMYQL 165 +I++L + + +V++YV E + +H R ++ + + Q+ Sbjct: 94 HIIKLYQVISTPTD------FFMVMEYVSGGELFDYICKH-GRVEE----MEARRLFQQI 142 Query: 166 FRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAP 225 ++ Y H + HRD+KP+N+LLD K+ DFG + + GE + S Y AP Sbjct: 143 LSAVDYCHRHMVVHRDLKPENVLLDAHMNA-KIADFGLSNMMSDGEFLRTSCGSPNYAAP 201 Query: 226 ELIFGATDYTSSIDVWSAGCVLAELLLG 253 E+I G +D+WS G +L LL G Sbjct: 202 EVISGRLYAGPEVDIWSCGVILYALLCG 229 >6NT9-A nrPDB Length = 742 Score = 71.2 bits (173), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 55/206 (26%), Positives = 103/206 (50%), Gaps = 23/206 (11%) Query: 59 TKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRF------KNRELQIMRKLDHCNIVRL 112 + ++G G+ V++ + +G+L AIK V + F + RE ++++KL+H NIV+L Sbjct: 12 SDILGQGATANVFRGRHKKTGDLFAIK-VFNNISFLRPVDVQMREFEVLKKLNHKNIVKL 70 Query: 113 RYFFYSSGEKKDEVYLNLVLDYVP-ETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAY 171 ++ E+ + L++++ P ++Y V S A LP + + + + + Sbjct: 71 ----FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNA-YGLPESEFLIVLRDVVGGMNH 125 Query: 172 IHSFGICHRDIKPQNLLL---DPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELI 228 + GI HR+IKP N++ + +V KL DFG+A++L E VS + Y P++ Sbjct: 126 LRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMY 185 Query: 229 FGAT-------DYTSSIDVWSAGCVL 247 A Y +++D+WS G Sbjct: 186 ERAVLRKDHQKKYGATVDLWSIGVTF 211 >4REW-A nrPDB Length = 540 Score = 71.2 bits (173), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 59/218 (27%), Positives = 100/218 (45%), Gaps = 29/218 (13%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN--------RELQIMRKLDHC 107 Y +G G+FG V K +G VA+K +L ++ ++ RE+Q ++ H Sbjct: 8 YILGDTLGVGTFGKVKVGKHELTGHKVAVK-ILNRQKIRSLDVVGKIRREIQNLKLFRHP 66 Query: 108 NIVRLRYFFYSSGEKKDEVYLNLVLDYVP-----ETVYRVARHYSRAKQTLPVIYVKLYM 162 +I++L Y ++++ V++YV + + + R + + L Sbjct: 67 HIIKL----YQVISTPSDIFM--VMEYVSGGELFDYICKNGRLDEKESRRL--------F 112 Query: 163 YQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYY 222 Q+ + Y H + HRD+KP+N+LLD K+ DFG + + GE + S Y Sbjct: 113 QQILSGVDYCHRHMVVHRDLKPENVLLDAHMNA-KIADFGLSNMMSDGEFLRTSCGSPNY 171 Query: 223 RAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGD 260 APE+I G +D+WS+G +L LL G F D Sbjct: 172 AAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDD 209 >4PL5-B nrPDB Length = 435 Score = 71.2 bits (173), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 59/207 (28%), Positives = 106/207 (51%), Gaps = 22/207 (10%) Query: 53 EVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQD-KRFKNRELQIMRKLD-HCNIV 110 ++S+ V+G+G+ G + + D+ + VA+K++L + F +RE+Q++R+ D H N++ Sbjct: 26 KISFCPKDVLGHGAEGTIVYKGMFDNRD-VAVKRILPECFSFADREVQLLRESDEHPNVI 84 Query: 111 RLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLA 170 R YF +KD + + ++ T+ A L I + ++Q LA Sbjct: 85 R--YF----CTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITL---LHQTTSGLA 135 Query: 171 YIHSFGICHRDIKPQNLLLDPDTAVLK----LCDFGSAKQLVRGEPNVSYIC----SRYY 222 ++HS I HRD+KP N+LL A + + DFG K+L G + S + + Sbjct: 136 HLHSLNIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGW 195 Query: 223 RAPELIFG--ATDYTSSIDVWSAGCVL 247 APE++ + T ++D++SAGCV Sbjct: 196 IAPEMLSEDCKDNPTYTVDIFSAGCVF 222 >5TQX-A nrPDB Length = 655 Score = 70.9 bits (172), Expect = 9e-13, Method: Compositional matrix adjust. Identities = 66/213 (30%), Positives = 102/213 (47%), Gaps = 37/213 (17%) Query: 62 IGNGSFGVV--YQAKLCDSGELVAIKKVLQDKRFKNRE-----LQIMRKLDHCNIVRLRY 114 +G G FG V YQ + D +AIK + KNRE +QIM+KL+H N+V+ Sbjct: 16 LGTGGFGNVCLYQHRELDLK--IAIKSCRLELSTKNRERWCHEIQIMKKLNHANVVK--- 70 Query: 115 FFYSSGEKKDEVYLNLVLDYVPETVYRVARHYS-----RAKQTLPVIYVKLYMYQLFRSL 169 + + +E LN+++ VP +A Y R P L Q+ L Sbjct: 71 ----ACDVPEE--LNILIHDVP----LLAMEYCSGGDLRKLLNKPENCCGLKESQILSLL 120 Query: 170 A-------YIHSFGICHRDIKPQNLLLDP--DTAVLKLCDFGSAKQLVRGEPNVSYICSR 220 + Y+H I HRD+KP+N++L + K+ D G AK + +GE ++ + Sbjct: 121 SDIGSGIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGELCTEFVGTL 180 Query: 221 YYRAPELIFGATDYTSSIDVWSAGCVLAELLLG 253 Y APEL F YT+++D WS G ++ E + G Sbjct: 181 QYLAPEL-FENKPYTATVDYWSFGTMVFECIAG 212 >5EZV-A nrPDB Length = 560 Score = 70.9 bits (172), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 56/208 (26%), Positives = 98/208 (47%), Gaps = 23/208 (11%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN--------RELQIMRKLDHC 107 Y +G G+FG V + +G VA+K +L ++ ++ RE+Q ++ H Sbjct: 30 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVK-ILNRQKIRSLDVVGKIKREIQNLKLFRHP 88 Query: 108 NIVRLRYFFYSSGEKKDEVYLNLVLDYVP--ETVYRVARHYSRAKQTLPVIYVKLYMYQL 165 +I++L + + +V++YV E + +H R ++ + + Q+ Sbjct: 89 HIIKLYQVISTPTD------FFMVMEYVSGGELFDYICKH-GRVEE----MEARRLFQQI 137 Query: 166 FRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAP 225 ++ Y H + HRD+KP+N+LLD K+ DFG + + GE + S Y AP Sbjct: 138 LSAVDYCHRHMVVHRDLKPENVLLDAHMNA-KIADFGLSNMMSDGEFLRTSCGSPNYAAP 196 Query: 226 ELIFGATDYTSSIDVWSAGCVLAELLLG 253 E+I G +D+WS G +L LL G Sbjct: 197 EVISGRLYAGPEVDIWSCGVILYALLCG 224 >3LLT-A nrPDB Length = 360 Score = 70.9 bits (172), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 74/327 (22%), Positives = 138/327 (42%), Gaps = 56/327 (17%) Query: 62 IGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNR---ELQIMRKLDHCNIVRLRYFFYS 118 +G+G+FG V + D+ + A+K V K++ E I++K+ + +I Y Sbjct: 43 MGDGTFGRVLLCQHIDNKKYYAVKVVRNIKKYTRSAKIEADILKKIQNDDINNNNIVKYH 102 Query: 119 SGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGIC 178 G+ ++ L+ + + ++Y + + +KLY ++ ++L Y+ + Sbjct: 103 -GKFMYYDHMCLIFEPLGPSLYEIIT--RNNYNGFHIEDIKLYCIEILKALNYLRKMSLT 159 Query: 179 HRDIKPQNLLLD------------------------PDTAVLKLCDFGSAKQLVRGEPNV 214 H D+KP+N+LLD + +KL DFG A + + + Sbjct: 160 HTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTKSTGIKLIDFGCAT--FKSDYHG 217 Query: 215 SYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLG 274 S I +R YRAPE+I + S D+WS GCVLAEL G +F ++ L + ++ Sbjct: 218 SIINTRQYRAPEVILNL-GWDVSSDMWSFGCVLAELYTGSLLFRTHEHMEHLAMMESIIQ 276 Query: 275 TPTREQIRE---------MNPNYTEFKFPQ-----------IKAHPWTKVFRPRTPPEAI 314 + + E +N + + +P+ K P K+ + + + Sbjct: 277 PIPKNMLYEATKTNGSKYVNKDELKLAWPENASSINSIKHVKKCLPLYKIIKHELFCDFL 336 Query: 315 ALCSRLLEYTPTARLTPLEACAHSFFD 341 +L+ PT R +P E H F + Sbjct: 337 Y---SILQIDPTLRPSPAELLKHKFLE 360 >2XIK-A nrPDB Length = 294 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 61/211 (28%), Positives = 99/211 (46%), Gaps = 19/211 (9%) Query: 51 PQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKV-----LQDKRFKNRELQIMRKLD 105 P+E+ +T IG GSFG VY+ + E+VAIK + + +E+ ++ + D Sbjct: 17 PEEL-FTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 75 Query: 106 HCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQL 165 I R YF G L ++++Y+ ++T Y+ + ++ Sbjct: 76 SPYITR--YF----GSYLKSTKLWIIMEYLGGGSALDLLKPGPLEET----YIATILREI 125 Query: 166 FRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGE-PNVSYICSRYYRA 224 + L Y+HS HRDIK N+LL V KL DFG A QL + +++ + ++ A Sbjct: 126 LKGLDYLHSERKIHRDIKAANVLLSEQGDV-KLADFGVAGQLTDTQIKRNTFVGTPFWMA 184 Query: 225 PELIFGATDYTSSIDVWSAGCVLAELLLGQP 255 PE+I + Y D+WS G EL G+P Sbjct: 185 PEVI-KQSAYDFKADIWSLGITAIELAKGEP 214 >5X5O-A nrPDB Length = 310 Score = 70.1 bits (170), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 58/211 (27%), Positives = 104/211 (49%), Gaps = 31/211 (14%) Query: 63 GNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFY----- 117 G GSFG VY+AK + VA+KK+L+ + +E +I+ L H NI++ FY Sbjct: 24 GGGSFGSVYRAKWISQDKEVAVKKLLKIE----KEAEILSVLSHRNIIQ----FYGVILE 75 Query: 118 --SSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHS- 174 + G + L + DY+ S + + + ++ + + + + Y+H Sbjct: 76 PPNYGIVTEYASLGSLYDYIN----------SNRSEEMDMDHIMTWATDVAKGMHYLHME 125 Query: 175 --FGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGAT 232 + HRD+K +N+++ D VLK+CDFG A + ++S + + + APE+I + Sbjct: 126 APVKVIHRDLKSRNVVIAAD-GVLKICDFG-ASRFHNHTTHMSLVGTFPWMAPEVI-QSL 182 Query: 233 DYTSSIDVWSAGCVLAELLLGQPIFPGDSGV 263 + + D +S G VL E+L + F G G+ Sbjct: 183 PVSETCDTYSYGVVLWEMLTREVPFKGLEGL 213 >2XNP-A nrPDB Length = 279 Score = 70.1 bits (170), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 66/225 (29%), Positives = 104/225 (46%), Gaps = 25/225 (11%) Query: 48 PDRPQ--EVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKV------LQDKRFKNRELQ 99 P R + EV YT IG GS+G + + G+++ K++ +K+ E+ Sbjct: 2 PSRAEDYEVLYT----IGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVN 57 Query: 100 IMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPE-TVYRVARHYSRAKQTLPVIYV 158 ++R+L H NIVR +Y + L +V++Y + V ++ +Q L +V Sbjct: 58 LLRELKHPNIVR----YYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFV 113 Query: 159 KLYMYQLFRSLAYIH-----SFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPN 213 M QL +L H + HRD+KP N+ LD V KL DFG A+ L Sbjct: 114 LRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNV-KLGDFGLARILNHDTSF 172 Query: 214 V-SYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIF 257 +++ + YY +PE + Y D+WS GC+L EL P F Sbjct: 173 AKTFVGTPYYMSPEQM-NRMSYNEKSDIWSLGCLLYELCALMPPF 216 >4CFH-A nrPDB Length = 493 Score = 70.1 bits (170), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 59/218 (27%), Positives = 100/218 (45%), Gaps = 29/218 (13%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN--------RELQIMRKLDHC 107 Y +G G+FG V K +G VA+K +L ++ ++ RE+Q ++ H Sbjct: 35 YILGDTLGVGTFGKVKVGKHELTGHKVAVK-ILNRQKIRSLDVVGKIRREIQNLKLFRHP 93 Query: 108 NIVRLRYFFYSSGEKKDEVYLNLVLDYVP-----ETVYRVARHYSRAKQTLPVIYVKLYM 162 +I++L Y ++++ V++YV + + + R + + L Sbjct: 94 HIIKL----YQVISTPSDIFM--VMEYVSGGELFDYICKNGRLDEKESRRL--------F 139 Query: 163 YQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYY 222 Q+ + Y H + HRD+KP+N+LLD K+ DFG + + GE + S Y Sbjct: 140 QQILSGVDYCHRHMVVHRDLKPENVLLDAHMNA-KIADFGLSNMMSDGEFLRTSCGSPNY 198 Query: 223 RAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGD 260 APE+I G +D+WS+G +L LL G F D Sbjct: 199 AAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDD 236 >6CMJ-A nrPDB Length = 321 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 77/278 (27%), Positives = 116/278 (41%), Gaps = 42/278 (15%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN---------------RELQI 100 YT IG GS+GVV A + A+K + + K + +E+ I Sbjct: 36 YTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGGCIQPRGPIEQVYQEIAI 95 Query: 101 MRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKL 160 ++KLDH N+V+L E D +Y+ V E V + + L + Sbjct: 96 LKKLDHPNVVKLVEVLDDPNE--DHLYM------VFELVNQGPVMEVPTLKPLSEDQARF 147 Query: 161 YMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVS-YICS 219 Y L + + Y+H I HRDIKP NLL+ D + K+ DFG + + + +S + + Sbjct: 148 YFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHI-KIADFGVSNEFKGSDALLSNTVGT 206 Query: 220 RYYRAPELIFGATDYTS--SIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIK--VLGT 275 + APE + S ++DVW+ G L + GQ F D + L IK L Sbjct: 207 PAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFM-DERIMCLHSKIKSQALEF 265 Query: 276 PTREQIRE-----------MNPNYTEFKFPQIKAHPWT 302 P + I E NP + P+IK HPW Sbjct: 266 PDQPDIAEDLKDLITRMLDKNPE-SRIVVPEIKLHPWV 302 >4RED-A nrPDB Length = 351 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 59/218 (27%), Positives = 100/218 (45%), Gaps = 29/218 (13%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN--------RELQIMRKLDHC 107 Y +G G+FG V K +G VA+K +L ++ ++ RE+Q ++ H Sbjct: 16 YILGDTLGVGTFGKVKVGKHELTGHAVAVK-ILNRQKIRSLDVVGKIRREIQNLKLFRHP 74 Query: 108 NIVRLRYFFYSSGEKKDEVYLNLVLDYVP-----ETVYRVARHYSRAKQTLPVIYVKLYM 162 +I++L Y ++++ V++YV + + + R + + L Sbjct: 75 HIIKL----YQVISTPSDIFM--VMEYVSGGELFDYICKNGRLDEKESRRL--------F 120 Query: 163 YQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYY 222 Q+ + Y H + HRD+KP+N+LLD K+ DFG + + GE + S Y Sbjct: 121 QQILSGVDYCHRHMVVHRDLKPENVLLDAHMNA-KIADFGLSNMMSDGEFLRTSCGSPNY 179 Query: 223 RAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGD 260 APE+I G +D+WS+G +L LL G F D Sbjct: 180 AAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDD 217 >3TAC-A nrPDB Length = 361 Score = 69.3 bits (168), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 86/308 (27%), Positives = 128/308 (41%), Gaps = 56/308 (18%) Query: 53 EVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKV----------LQDKRFKNRELQIMR 102 E Y +VIG G F VV + ++G+ A+K V L + K RE I Sbjct: 25 EDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLK-REASICH 83 Query: 103 KLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYV--PETVYRVARHYSRAKQTLPVIYVKL 160 L H +IV L + S G L +V +++ + + + + + A Sbjct: 84 MLKHPHIVELLETYSSDG------MLYMVFEFMDGADLCFEIVKR-ADAGFVYSEAVASH 136 Query: 161 YMYQLFRSLAYIHSFGICHRDIKPQNLLL--DPDTAVLKLCDFGSAKQLVRGEPNV---S 215 YM Q+ +L Y H I HRD+KP +LL ++A +KL FG A QL GE + Sbjct: 137 YMRQILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQL--GESGLVAGG 194 Query: 216 YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVE-IIKVLG 274 + + ++ APE++ Y +DVW G +L LL G F G ++L E IIK Sbjct: 195 RVGTPHFMAPEVV-KREPYGKPVDVWGCGVILFILLSGCLPFYGTK--ERLFEGIIK--- 248 Query: 275 TPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEA 334 +MNP W+ + A L R+L P R+T EA Sbjct: 249 -----GKYKMNPR------------QWSHI-----SESAKDLVRRMLMLDPAERITVYEA 286 Query: 335 CAHSFFDE 342 H + E Sbjct: 287 LNHPWLKE 294 >4NIF-A nrPDB Length = 333 Score = 69.3 bits (168), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 78/294 (26%), Positives = 129/294 (43%), Gaps = 41/294 (13%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIM-RKLDHCNIVRLRY 114 Y + IG GS+ + + A+K + + KR + E++I+ R H NI+ L+ Sbjct: 10 YVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIEILLRYGQHPNIITLKD 69 Query: 115 FFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHS 174 Y G+ VYL L E + ++ R +++ + ++ + +++ Y+HS Sbjct: 70 V-YDDGK---HVYLVTELMRGGELLDKILRQKFFSEREASFV-----LHTIGKTVEYLHS 120 Query: 175 FGICHRDIKPQNLLLDPDTA---VLKLCDFGSAKQLVRGEPNVSYI-C-SRYYRAPELIF 229 G+ HRD+KP N+L ++ L++CDFG AKQL R E + C + + APE + Sbjct: 121 QGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQL-RAENGLLMTPCYTANFVAPE-VL 178 Query: 230 GATDYTSSIDVWSAGCVLAELLLG-QPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNY 288 Y D+WS G +L +L G P G S D EI+ +G+ Sbjct: 179 KRQGYDEGCDIWSLGILLYTMLAGYTPFANGPS--DTPEEILTRIGSG------------ 224 Query: 289 TEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDE 342 KF + W V A L S++L P RLT + H + + Sbjct: 225 ---KFT-LSGGNWNTV-----SETAKDLVSKMLHVDPHQRLTAKQVLQHPWVTQ 269 >3FME-A nrPDB Length = 290 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 72/289 (24%), Positives = 133/289 (46%), Gaps = 43/289 (14%) Query: 62 IGNGSFGVVYQAKLCDSGELVAIKKVL-----QDKRFKNRELQI-MRKLDHCNIVRLRYF 115 +G G++GVV + + SG+++A+K++ Q+++ +L I MR +D V Sbjct: 15 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVT---- 70 Query: 116 FYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHS- 174 FY + ++ +V+ + ++ + ++ + + QT+P + + ++L ++HS Sbjct: 71 FYGALFREGDVW--ICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSK 128 Query: 175 FGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELI---FGA 231 + HRD+KP N+L++ +K+CDFG + LV + Y APE I Sbjct: 129 LSVIHRDVKPSNVLINA-LGQVKMCDFGISGYLVDDVAKDIDAGCKPYMAPERINPELNQ 187 Query: 232 TDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEF 291 Y+ D+WS G + EL + + FP DS GTP +Q++++ E Sbjct: 188 KGYSVKSDIWSLGITMIELAILR--FPYDS-----------WGTPF-QQLKQV----VEE 229 Query: 292 KFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF 340 PQ+ A ++ F + S+ L+ R T E H FF Sbjct: 230 PSPQLPADKFSAEF--------VDFTSQCLKKNSKERPTYPELMQHPFF 270 >6O8B-A nrPDB Length = 665 Score = 68.9 bits (167), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 54/203 (26%), Positives = 102/203 (50%), Gaps = 23/203 (11%) Query: 59 TKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRF------KNRELQIMRKLDHCNIVRL 112 + ++G G+ V++ + +G+L AIK V + F + RE ++++KL+H NIV+L Sbjct: 20 SDILGQGATANVFRGRHKKTGDLFAIK-VFNNISFLRPVDVQMREFEVLKKLNHKNIVKL 78 Query: 113 RYFFYSSGEKKDEVYLNLVLDYVP-ETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAY 171 ++ E+ + L++++ P ++Y V S A LP + + + + + Sbjct: 79 ----FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNA-YGLPESEFLIVLRDVVGGMNH 133 Query: 172 IHSFGICHRDIKPQNLLL---DPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELI 228 + GI HR+IKP N++ + +V KL DFG+A++L E V + Y P++ Sbjct: 134 LRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVELYGTEEYLHPDMY 193 Query: 229 FGAT-------DYTSSIDVWSAG 244 A Y +++D+WS G Sbjct: 194 ERAVLRKDHQKKYGATVDLWSIG 216 >4IX6-A nrPDB Length = 350 Score = 68.9 bits (167), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 60/207 (28%), Positives = 89/207 (42%), Gaps = 37/207 (17%) Query: 159 KLYMYQLFRSLAYIHSFGICHRDIKPQNLL-LDPDTAVLKLCDFGSAKQLVRGEPNVSYI 217 K M +L SLA +H G+ HRD+KP NL+ + D VLKL D G+A + ++Y Sbjct: 146 KKAMRELLGSLARLHECGVVHRDVKPANLIAAEKDGGVLKLIDLGAAALCLPLPETLNYY 205 Query: 218 CS------RYYRAPELIF---GATDYTSS-------------IDVWSAGCVLAEL-LLGQ 254 RY +A EL G+ T D WSAGCV+ +L ++G Sbjct: 206 PGDGPADPRYAKADELYLLPPGSPRPTKDNAAKLWEAHKPDRFDSWSAGCVMLQLAVVG- 264 Query: 255 PIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAI 314 D+G+++ + K +G E + Y F + A+ Sbjct: 265 --LRTDAGLERFLADYKAVGYDVNAFRGEKSGEYGTMDFAALDANGGA----------GW 312 Query: 315 ALCSRLLEYTPTARLTPLEACAHSFFD 341 LC RL+E AR + A +H+FFD Sbjct: 313 DLCQRLMEAERDARASCEAALSHAFFD 339 >6CQF-A nrPDB Length = 297 Score = 68.9 bits (167), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 60/203 (29%), Positives = 98/203 (48%), Gaps = 21/203 (10%) Query: 62 IGNGSFGVVYQAKLCDSGELVAIKKVLQ----DKRFKNRELQIMRKLDHCNIVRLR--YF 115 +G G++G V++A+ SG+LVA+K V D +E+ I++ H NIV Y Sbjct: 24 LGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRHANIVAYHGSYL 83 Query: 116 FYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSF 175 + +K + + + +Y+V S L + YV ++ + LAY+HS Sbjct: 84 WL----QKLWICMEFCGAGSLQDIYQVTGSLSE----LQISYV---CREVLQGLAYLHSQ 132 Query: 176 GICHRDIKPQNLLLDPDTAVLKLCDFGSAKQL-VRGEPNVSYICSRYYRAPELIFGATD- 233 HRDIK N+L++ D ++L DFG + Q+ +++I + Y+ APE+ A Sbjct: 133 KKIHRDIKGANILIN-DAGEVRLADFGISAQIGATLARRLAFIGTPYWMAPEVAAVALKG 191 Query: 234 -YTSSIDVWSAGCVLAELLLGQP 255 Y D+WS G EL QP Sbjct: 192 GYNELCDIWSLGITAIELAELQP 214 >3UIM-A nrPDB Length = 326 Score = 68.6 bits (166), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 66/217 (30%), Positives = 109/217 (50%), Gaps = 26/217 (11%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLD------HCN 108 ++++ ++G G FG VY+ +L D G LVA+K+ L+++R + ELQ +++ H N Sbjct: 31 NFSNKNILGRGGFGKVYKGRLAD-GTLVAVKR-LKEERTQGGELQFQTEVEMISMAVHRN 88 Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVPE-TVYRVARHYSRAKQTLPVIYVKLYMYQL-- 165 ++RLR F + E+ LV Y+ +V R R + P+ + K L Sbjct: 89 LLRLRGFCMTPTERL------LVYPYMANGSVASCLR--ERPESQPPLDWPKRQRIALGS 140 Query: 166 FRSLAYIHSF---GICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYIC--SR 220 R LAY+H I HRD+K N+LLD + + + DFG AK + + +V+ + Sbjct: 141 ARGLAYLHDHCDPKIIHRDVKAANILLDEEFEAV-VGDFGLAKLMDYKDTHVTTAVRGTI 199 Query: 221 YYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIF 257 + APE + + DV+ G +L EL+ GQ F Sbjct: 200 GHIAPEYL-STGKSSEKTDVFGYGVMLLELITGQRAF 235 >6HV0-A nrPDB Length = 416 Score = 68.6 bits (166), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 59/207 (28%), Positives = 105/207 (50%), Gaps = 22/207 (10%) Query: 53 EVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDK-RFKNRELQIMRKLD-HCNIV 110 ++S+ V+G+G+ G + + D+ + VA+K++L + F +RE+Q++R+ D H N++ Sbjct: 7 KISFCPKDVLGHGAEGTIVYRGMFDNRD-VAVKRILPECFSFADREVQLLRESDEHPNVI 65 Query: 111 RLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLA 170 R YF +KD + + ++ T+ A L I + + Q LA Sbjct: 66 R--YF----CTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITL---LQQTTSGLA 116 Query: 171 YIHSFGICHRDIKPQNLLLDPDTAVLK----LCDFGSAKQLVRGEPNVSYIC----SRYY 222 ++HS I HRD+KP N+L+ A K + DFG K+L G + S + + Sbjct: 117 HLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGW 176 Query: 223 RAPELIFG--ATDYTSSIDVWSAGCVL 247 APE++ + T ++D++SAGCV Sbjct: 177 IAPEMLSEDCKENPTYTVDIFSAGCVF 203 >5FET-A nrPDB Length = 847 Score = 68.6 bits (166), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 39/108 (36%), Positives = 64/108 (59%), Gaps = 5/108 (4%) Query: 159 KLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYIC 218 + Y+ + ++ Y+H I +RD+KP+N+LLD V KL DFG AK+ ++G + + Sbjct: 636 QFYLGSIILAIEYLHERNIVYRDLKPENILLDKQGYV-KLIDFGCAKK-IQGRA-YTLVG 692 Query: 219 SRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQL 266 + +Y APE+I G Y ++D+W+ G L E + G P+ G+ DQL Sbjct: 693 TPHYMAPEVILGKG-YGCTVDIWALGVCLYEFICG-PLPFGNDQEDQL 738 >4QMW-A nrPDB Length = 310 Score = 68.2 bits (165), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 57/219 (26%), Positives = 99/219 (45%), Gaps = 35/219 (15%) Query: 51 PQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKV-----LQDKRFKNRELQIMRKLD 105 P+E+ +T + IG GSFG V++ + ++VAIK + + +E+ ++ + D Sbjct: 27 PEEL-FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 85 Query: 106 HCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVI--------Y 157 + + +Y S Y+ +T + Y L ++ Sbjct: 86 SPYVTK----YYGS--------------YLKDTKLWIIMEYLGGGSALDLLEPGPLDETQ 127 Query: 158 VKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGE-PNVSY 216 + + ++ + L Y+HS HRDIK N+LL V KL DFG A QL + ++ Sbjct: 128 IATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEV-KLADFGVAGQLTDTQIKRNTF 186 Query: 217 ICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQP 255 + + ++ APE+I + Y S D+WS G EL G+P Sbjct: 187 VGTPFWMAPEVI-KQSAYDSKADIWSLGITAIELARGEP 224 >1KOB-A nrPDB Length = 387 Score = 67.8 bits (164), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 69/286 (24%), Positives = 119/286 (41%), Gaps = 43/286 (15%) Query: 62 IGNGSFGVVYQAKLCDSGELVAIKKVLQ----DKRFKNRELQIMRKLDHCNIVRLRYFFY 117 +G+G+FGVV++ +G + K + DK E+ IM +L H ++ L F Sbjct: 59 LGSGAFGVVHRCVEKATGRVFVAKFINTPYPLDKYTVKNEISIMNQLHHPKLINLHDAF- 117 Query: 118 SSGEKKDEVYLNLVLDYVP--ETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSF 175 +D+ + L+L+++ E R+A + + V YM Q L ++H Sbjct: 118 -----EDKYEMVLILEFLSGGELFDRIAAEDYKMSEA----EVINYMRQACEGLKHMHEH 168 Query: 176 GICHRDIKPQNLLLDPDTA-VLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDY 234 I H DIKP+N++ + A +K+ DFG A +L E + + APE++ Sbjct: 169 SIVHLDIKPENIMCETKKASSVKIIDFGLATKLNPDEIVKVTTATAEFAAPEIV-DREPV 227 Query: 235 TSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFP 294 D+W+ G + LL G F G+ ++ L + ++ + + E F Sbjct: 228 GFYTDMWAIGVLGYVLLSGLSPFAGEDDLETL------------QNVKRCDWEFDEDAFS 275 Query: 295 QIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF 340 + PEA LL+ P RLT +A H + Sbjct: 276 SVS-------------PEAKDFIKNLLQKEPRKRLTVHDALEHPWL 308 >5HVK-A nrPDB Length = 315 Score = 67.8 bits (164), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 57/223 (25%), Positives = 112/223 (50%), Gaps = 35/223 (15%) Query: 50 RPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVL----QDKRFKNRELQIMRKLD 105 RP ++ + + V+G G FG + ++GE++ +K+++ + +R +E+++MR L+ Sbjct: 12 RPSDLIHGE--VLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLE 69 Query: 106 HCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYR--VARHYSRAKQTLPVIYVKLYMY 163 H N+++ Y KD+ LN + +Y+ R + S+ + V + K Sbjct: 70 HPNVLKFIGVLY-----KDK-RLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAK---- 119 Query: 164 QLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLV--RGEPN-------- 213 + +AY+HS I HR++ N L+ + V+ + DFG A+ +V + +P Sbjct: 120 DIASGMAYLHSMNIIHRNLNSHNCLVRENKNVV-VADFGLARLMVDEKTQPEGLRSLKKP 178 Query: 214 -----VSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELL 251 + + + Y+ APE+I G + Y +DV+S G VL E++ Sbjct: 179 DRKKRYTVVGNPYWMAPEMINGRS-YDEKVDVFSFGIVLCEII 220 >3UTO-A nrPDB Length = 573 Score = 67.8 bits (164), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 76/308 (24%), Positives = 131/308 (42%), Gaps = 47/308 (15%) Query: 62 IGNGSFGVVYQAKLCDSGELVAIKKVL----QDKRFKNRELQIMRKLDHCNIVRLRYFFY 117 +G G+FGVV++ +G A K V+ DK +E+Q M L H +V L F Sbjct: 165 LGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKETVRKEIQTMSVLRHPTLVNLHDAF- 223 Query: 118 SSGEKKDEVYLNLVLDYVP--ETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSF 175 +D+ + ++ +++ E +VA +++ + V YM Q+ + L ++H Sbjct: 224 -----EDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAV----EYMRQVCKGLCHMHEN 274 Query: 176 GICHRDIKPQNLLLDPD-TAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFG--AT 232 H D+KP+N++ + LKL DFG L + + + APE+ G Sbjct: 275 NYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTTGTAEFAAPEVAEGKPVG 334 Query: 233 DYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEI-----------IKVLGTPTREQI 281 YT D+WS G + LL G F G++ + L + + ++ I Sbjct: 335 YYT---DMWSVGVLSYILLSGLSPFGGENDDETLRNVKSCDWNMDDSAFSGISEDGKDFI 391 Query: 282 REM---NPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHS 338 R++ +PN T Q HPW TP A S++ P++R T + + Sbjct: 392 RKLLLADPN-TRMTIHQALEHPWL------TPGNAPGRDSQI----PSSRYTKIRDSIKT 440 Query: 339 FFDELRDP 346 +D +P Sbjct: 441 KYDAWPEP 448 >5HIE-A nrPDB Length = 302 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 67/225 (29%), Positives = 106/225 (47%), Gaps = 39/225 (17%) Query: 62 IGNGSFGVVYQAKLCDSGELVAIKKVL--QDKRFKNRELQIMRKLDHCNIVRLRYFFYSS 119 IG+GSFG VY+ K VA+K + Q + FKN E+ ++RK H NI L + YS+ Sbjct: 44 IGSGSFGTVYKGKWHGD---VAVKMLTPQQLQAFKN-EVGVLRKTRHVNI--LLFMGYST 97 Query: 120 GEK---------KDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLA 170 + +Y +L ++ ET + + + A+QT + + Sbjct: 98 KPQLAIVTQWCEGSSLYHHL---HIIETKFEMIKLIDIARQTA-------------QGMD 141 Query: 171 YIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSA--KQLVRGEPNVSYIC-SRYYRAPEL 227 Y+H+ I HRD+K N+ L D V K+ DFG A K G + S + APE+ Sbjct: 142 YLHAKSIIHRDLKSNNIFLHEDLTV-KIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEV 200 Query: 228 IFGATD--YTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEII 270 I Y+ DV++ G VL EL+ GQ + + DQ++ ++ Sbjct: 201 IRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMV 245 >5H2U-A nrPDB Length = 267 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 67/228 (29%), Positives = 118/228 (51%), Gaps = 19/228 (8%) Query: 49 DRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNR----ELQIMRKL 104 +RP+E +T + +G+G FG V++ D + VAIK + +D + E+Q M+KL Sbjct: 2 ERPRE-EFTLCRKLGSGYFGEVFEGLWKDRVQ-VAIKVISRDNLLHQQMLQSEIQAMKKL 59 Query: 105 DHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQ 164 H +I+ L Y S G D VY+ L ++ + R ++ LPV + +Q Sbjct: 60 RHKHILAL-YAVVSVG---DPVYIITEL-MAKGSLLELLR--DSDEKVLPVSELLDIAWQ 112 Query: 165 LFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYR- 223 + + Y+ S HRD+ +N+L+ +T + K+ DFG A+ L++ + +S+ + Y+ Sbjct: 113 VAEGMCYLESQNYIHRDLAARNILVGENT-LCKVGDFGLAR-LIKEDVYLSHDHNIPYKW 170 Query: 224 -APELIFGATDYTSSIDVWSAGCVLAELL-LGQPIFPGDSGVDQLVEI 269 APE + Y++ DVWS G +L E+ GQ +PG S + + + Sbjct: 171 TAPEAL-SRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRV 217 >1KOA-A nrPDB Length = 491 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 76/308 (24%), Positives = 131/308 (42%), Gaps = 47/308 (15%) Query: 62 IGNGSFGVVYQAKLCDSGELVAIKKVL----QDKRFKNRELQIMRKLDHCNIVRLRYFFY 117 +G G+FGVV++ +G A K V+ DK +E+Q M L H +V L F Sbjct: 59 LGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKETVRKEIQTMSVLRHPTLVNLHDAF- 117 Query: 118 SSGEKKDEVYLNLVLDYVP--ETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSF 175 +D+ + ++ +++ E +VA +++ + V YM Q+ + L ++H Sbjct: 118 -----EDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAV----EYMRQVCKGLCHMHEN 168 Query: 176 GICHRDIKPQNLLLDPD-TAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFG--AT 232 H D+KP+N++ + LKL DFG L + + + APE+ G Sbjct: 169 NYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTTGTAEFAAPEVAEGKPVG 228 Query: 233 DYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEI-----------IKVLGTPTREQI 281 YT D+WS G + LL G F G++ + L + + ++ I Sbjct: 229 YYT---DMWSVGVLSYILLSGLSPFGGENDDETLRNVKSCDWNMDDSAFSGISEDGKDFI 285 Query: 282 REM---NPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHS 338 R++ +PN T Q HPW TP A S++ P++R T + + Sbjct: 286 RKLLLADPN-TRMTIHQALEHPWL------TPGNAPGRDSQI----PSSRYTKIRDSIKT 334 Query: 339 FFDELRDP 346 +D +P Sbjct: 335 KYDAWPEP 342 >5B2L-A nrPDB Length = 324 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 78/296 (26%), Positives = 131/296 (44%), Gaps = 38/296 (12%) Query: 62 IGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRE--LQIMRKLDHCNIVRLR-----Y 114 +G+G+ G V++ + +G ++A+K Q +R N+E +I+ LD V L+ Y Sbjct: 25 MGSGTCGQVWKMRFRKTGHVIAVK---QMRRSGNKEENKRILMDLD----VVLKSHDCPY 77 Query: 115 FFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYI-H 173 G + + ++ + + ++ + R + +P + + ++L Y+ Sbjct: 78 IVQCFGTFITNTDVFIAMELMGTSAEKLKK---RMQGPIPERILGKMTVAIVKALYYLKE 134 Query: 174 SFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIF---- 229 G+ HRD+KP N+LLD + +KLCDFG + +LV + Y APE I Sbjct: 135 KHGVIHRDVKPSNILLD-ERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDP 193 Query: 230 GATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYT 289 DY DVWS G L EL GQ FP + + KVL ++ + P + Sbjct: 194 TKPDYDIRADVWSLGISLVELATGQ--FPYKNCKTDFEVLTKVL-----QEEPPLLPGHM 246 Query: 290 EFK--FPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDEL 343 F F TK R R P+ ++LLE++ R LE S+F ++ Sbjct: 247 GFSGDFQSFVKDCLTKDHRKR--PKY----NKLLEHSFIKRYETLEVDVASWFKDV 296 >1TKI-A nrPDB Length = 321 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 73/292 (25%), Positives = 126/292 (43%), Gaps = 50/292 (17%) Query: 56 YTDTKVIGNGSFGVVYQ-----AKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIV 110 Y + +G G FG+V++ +K + V +K D+ +E+ I+ H NI+ Sbjct: 7 YMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGT--DQVLVKKEISILNIARHRNIL 64 Query: 111 RLRYFFYSSGEKKDEVYLNLVLDYVP--ETVYRVARHYSRAKQTLPVIYVKLYMYQLFRS 168 L F S E L ++ +++ + R+ + V YV +Q+ + Sbjct: 65 HLHESFESMEE------LVMIFEFISGLDIFERINTSAFELNEREIVSYV----HQVCEA 114 Query: 169 LAYIHSFGICHRDIKPQNLLLDP-DTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPEL 227 L ++HS I H DI+P+N++ ++ +K+ +FG A+QL G+ + Y APE Sbjct: 115 LQFLHSHNIGHFDIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLFTAPEYYAPE- 173 Query: 228 IFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPN 287 + +++ D+WS G ++ LL G F ++ Q++E I MN Sbjct: 174 VHQHDVVSTATDMWSLGTLVYVLLSGINPFLAETN-QQIIENI-------------MNAE 219 Query: 288 YT--EFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAH 337 YT E F +I EA+ RLL +R+T EA H Sbjct: 220 YTFDEEAFKEI-------------SIEAMDFVDRLLVKERKSRMTASEALQH 258 >2YZA-A nrPDB Length = 276 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 56/208 (26%), Positives = 97/208 (46%), Gaps = 23/208 (11%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN--------RELQIMRKLDHC 107 Y +G G+FG V + +G VA+K +L ++ ++ RE+Q ++ H Sbjct: 13 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVK-ILNRQKIRSLDVVGKIKREIQNLKLFRHP 71 Query: 108 NIVRLRYFFYSSGEKKDEVYLNLVLDYVP--ETVYRVARHYSRAKQTLPVIYVKLYMYQL 165 +I++L + + +V++YV E + +H R ++ + + Q+ Sbjct: 72 HIIKLYQVISTPTD------FFMVMEYVSGGELFDYICKH-GRVEE----MEARRLFQQI 120 Query: 166 FRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAP 225 ++ Y H + HRD+KP+N+LLD K+ DFG + + GE S Y AP Sbjct: 121 LSAVDYCHRHMVVHRDLKPENVLLDAHMNA-KIADFGLSNMMSDGEFLRDSCGSPNYAAP 179 Query: 226 ELIFGATDYTSSIDVWSAGCVLAELLLG 253 E+I G +D+WS G +L LL G Sbjct: 180 EVISGRLYAGPEVDIWSCGVILYALLCG 207 >4JG6-A nrPDB Length = 355 Score = 67.0 bits (162), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 81/307 (26%), Positives = 138/307 (44%), Gaps = 45/307 (14%) Query: 62 IGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIM-RKLDHCNIVRLRYFFYSSG 120 IG GS+ V + + A+K + + KR E++I+ R H NI+ L+ Y G Sbjct: 43 IGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLK-DVYDDG 101 Query: 121 EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR 180 + VY+ L E + ++ R +++ + ++ + +++ Y+H+ G+ HR Sbjct: 102 KY---VYVVTELMKGGELLDKILRQKFFSEREASAV-----LFTITKTVEYLHAQGVVHR 153 Query: 181 DIKPQNLLLDPDTA---VLKLCDFGSAKQLVRGEPNVSYI-C-SRYYRAPELIFGATDYT 235 D+KP N+L ++ +++CDFG AKQL R E + C + + APE + Y Sbjct: 154 DLKPSNILYVDESGNPESIRICDFGFAKQL-RAENGLLMTPCYTANFVAPE-VLERQGYD 211 Query: 236 SSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQ 295 ++ D+WS G +L +L G F + D EI+ +G+ KF Sbjct: 212 AACDIWSLGVLLYTMLTGYTPF-ANGPDDTPEEILARIGSG---------------KF-S 254 Query: 296 IKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSF---FDELRDPNVKLPN 352 + W V A L S++L P RLT H + +D+L P +L N Sbjct: 255 LSGGYWNSV-----SDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQL--PQYQL-N 306 Query: 353 GRDTPAL 359 +D P L Sbjct: 307 RQDAPHL 313 >3M42-A nrPDB Length = 299 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 80/293 (27%), Positives = 120/293 (40%), Gaps = 66/293 (22%) Query: 59 TKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHC-NIVRLRYFFY 117 ++V+G G G V Q + E A+K +LQD RE+++ + C +IVR+ Sbjct: 23 SQVLGLGINGKVLQIFNKRTQEKFALK-MLQDCPKARREVELHWRASQCPHIVRIV---- 77 Query: 118 SSGEKKDEVYLNL-----VLDYVPETV---YRVARHYSRAKQTLPVIYVKLYMYQLFRSL 169 +VY NL L V E + +R R Q M + ++ Sbjct: 78 -------DVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAI 130 Query: 170 AYIHSFGICHRDIKPQNLLLDPD--TAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPEL 227 Y+HS I HRD+KP+NLL A+LKL DFG AK+ GE Sbjct: 131 QYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT-GE---------------- 173 Query: 228 IFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPN 287 Y S D+WS G ++ LL G P F + G+ + + +IR Sbjct: 174 -----KYDKSCDMWSLGVIMYILLCGYPPFYSNHGL--------AISPGMKTRIR----- 215 Query: 288 YTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF 340 +++FP + W++V E L LL+ PT R+T E H + Sbjct: 216 MGQYEFPNPE---WSEV-----SEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 260 >4X7Q-B nrPDB Length = 312 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 59/225 (26%), Positives = 94/225 (41%), Gaps = 23/225 (10%) Query: 53 EVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKV----------LQDKRFKNRELQIMR 102 E Y ++G G FG V+ VAIK + L D E+ ++ Sbjct: 30 EAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLW 89 Query: 103 KL----DHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYV 158 K+ H ++RL +F E ++ L L + ++ Y K L Sbjct: 90 KVGAGGGHPGVIRLLDWF----ETQEGFMLVLERPLPAQDLF----DYITEKGPLGEGPS 141 Query: 159 KLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYIC 218 + + Q+ ++ + HS G+ HRDIK +N+L+D KL DFGS L+ EP + Sbjct: 142 RCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGA-LLHDEPYTDFDG 200 Query: 219 SRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGV 263 +R Y PE I + VWS G +L +++ G F D + Sbjct: 201 TRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEI 245 >3HNG-A nrPDB Length = 360 Score = 66.2 bits (160), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 49/164 (29%), Positives = 80/164 (48%), Gaps = 15/164 (9%) Query: 161 YMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSR 220 Y +Q+ R + ++ S HRD+ +N+LL + V+K+CDFG A+ + + V +R Sbjct: 204 YSFQVARGMEFLSSRKCIHRDLAARNILLSENN-VVKICDFGLARDIYKNPDYVRKGDTR 262 Query: 221 Y---YRAPELIFGATDYTSSIDVWSAGCVLAELL-LGQPIFPGDSGVDQLVEIIKVLGTP 276 + APE IF Y++ DVWS G +L E+ LG +PG V++ + + Sbjct: 263 LPLKWMAPESIFDKI-YSTKSDVWSYGVLLWEIFSLGGSPYPG-------VQMDEDFCSR 314 Query: 277 TREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRL 320 RE +R P Y+ + QI W + P+ P L +L Sbjct: 315 LREGMRMRAPEYSTPEIYQIMLDCWHR--DPKERPRFAELVEKL 356 >4CSV-A nrPDB Length = 275 Score = 66.2 bits (160), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 65/240 (27%), Positives = 113/240 (47%), Gaps = 34/240 (14%) Query: 47 GPDRPQEV---SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN---RELQI 100 GP E+ T + +G+G FG VY+ K + VA+K + + +E QI Sbjct: 1 GPHDKWEIPRSEITLERKLGSGQFGEVYEGKWRNYNIEVAVKTLKEGTMSVEEFLQEAQI 60 Query: 101 MRKLDHCNIVRLRYFFYSSGEKKDEVYL-------NLVLDYVPETVYRVARHYSRAKQTL 153 M+KL H N+V+L Y K+ +Y+ +LDY+ + H A+ L Sbjct: 61 MKKLKHPNLVQL----YGVCTKEPPIYIITEYMSHGSLLDYLRD----CEGHTVNAQALL 112 Query: 154 PVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPN 213 + Q+ +AY+ S HRD+ +N L+ + V+K+ DFG A+ L+ + Sbjct: 113 DM------AAQVASGMAYLESQNFIHRDLAARNCLVGENN-VVKVADFGLAR-LINEDEY 164 Query: 214 VSYICSRY---YRAPELIFGATDYTSSIDVWSAGCVLAELL-LGQPIFPGDSGVDQLVEI 269 + +++ + APE I ++ DVW+ G +L E+ GQ +PG SG + + ++ Sbjct: 165 TARAGAKFPIKWTAPEAI-SYNRFSIKSDVWAFGILLWEIFTYGQVPYPGMSGSEVIEQV 223 >4G3E-A nrPDB Length = 352 Score = 65.9 bits (159), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 60/213 (28%), Positives = 98/213 (46%), Gaps = 26/213 (12%) Query: 52 QEVSY-TDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIV 110 +EV + T +G GSFG V++ K +G A+KKV + + F+ EL L IV Sbjct: 71 EEVHWMTHQPRVGRGSFGEVHRMKDKQTGFQCAVKKV-RLEVFRVEELVACAGLSSPRIV 129 Query: 111 RLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLA 170 L G ++ ++N+ ++ + + LP Y+ Q L Sbjct: 130 PL------YGAVREGPWVNIFMELLEGGSLG---QLIKQMGCLPEDRALYYLGQALEGLE 180 Query: 171 YIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSA---------KQLVRGEPNVSYI-CSR 220 Y+H+ I H D+K N+LL D + LCDFG A K L+ G+ YI + Sbjct: 181 YLHTRRILHGDVKADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGD----YIPGTE 236 Query: 221 YYRAPELIFGATDYTSSIDVWSAGCVLAELLLG 253 + APE++ G + +D+WS+ C++ +L G Sbjct: 237 THMAPEVVMG-KPCDAKVDIWSSCCMMLHMLNG 268 >4FZF-B nrPDB Length = 283 Score = 65.9 bits (159), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 59/211 (27%), Positives = 100/211 (47%), Gaps = 19/211 (9%) Query: 51 PQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKV-----LQDKRFKNRELQIMRKLD 105 P+E+ +T + IG GSFG V++ + ++VAIK + + +E+ ++ + D Sbjct: 6 PEEL-FTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 64 Query: 106 HCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQL 165 + + Y Y G K L ++++Y+ A RA + + ++ Sbjct: 65 SSYVTKY-YGSYLKGSK-----LWIIMEYLGGGS---ALDLLRAG-PFDEFQIATMLKEI 114 Query: 166 FRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGE-PNVSYICSRYYRA 224 + L Y+HS HRDIK N+LL V KL FG A QL + +++ + ++ A Sbjct: 115 LKGLDYLHSEKKIHRDIKAANVLLSEQGDV-KLAAFGVAGQLTDTQIKRNTFVGTPFWMA 173 Query: 225 PELIFGATDYTSSIDVWSAGCVLAELLLGQP 255 PE+I + Y S D+WS G EL G+P Sbjct: 174 PEVI-QQSAYDSKADIWSLGITAIELAKGEP 203 >4M7I-A nrPDB Length = 299 Score = 65.9 bits (159), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 63/224 (28%), Positives = 108/224 (48%), Gaps = 42/224 (18%) Query: 60 KVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNREL---QIMR------KLDHCNIV 110 + +G G FGVV++AK AIK++ R NREL ++MR KL+H IV Sbjct: 11 QCLGRGGFGVVFEAKNKVDDCNYAIKRI----RLPNRELAREKVMREVKALAKLEHPGIV 66 Query: 111 RLRYFFYSSGEKKD---------EVYLNLVLDYV-PETVYRVARHYSRAKQTLPVIYVKL 160 R +F + EK +VYL + + E + ++ + + + Sbjct: 67 R---YFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHI 123 Query: 161 YMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGE-------PN 213 ++ Q+ ++ ++HS G+ HRD+KP N+ D V+K+ DFG + + E P Sbjct: 124 FL-QIAEAVEFLHSKGLMHRDLKPSNIFFTMDD-VVKVGDFGLVTAMDQDEEEQTVLTPM 181 Query: 214 VSY------ICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELL 251 +Y + ++ Y +PE I G + Y+ +D++S G +L ELL Sbjct: 182 PAYARHTGQVGTKLYMSPEQIHGNS-YSHKVDIFSLGLILFELL 224 >4TPT-A nrPDB Length = 303 Score = 65.5 bits (158), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 55/221 (24%), Positives = 105/221 (47%), Gaps = 39/221 (17%) Query: 60 KVIGNGSFGVVYQAKLCDSGELVAIKKVLQ-----DKRFKNRELQIMRKLDHCNIVRLRY 114 +V+G G FG + +G+++ +K++++ K F E+++MR LDH N+++ Sbjct: 6 EVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLT-EVKVMRSLDHPNVLKFIG 64 Query: 115 FFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHS 174 Y +KK LNL+ +Y+ + + R+ P + + +AY+HS Sbjct: 65 VLYK--DKK----LNLLTEYIEGGTLK---DFLRSMDPFPWQQKVRFAKGIASGMAYLHS 115 Query: 175 FGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRG---------------------EPN 213 I HRD+ N L+ D V+ + DFG ++ +V + Sbjct: 116 MCIIHRDLNSHNCLIKLDKTVV-VADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKR 174 Query: 214 VSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQ 254 + + + Y+ APE++ G + Y ++D++S G VL E ++GQ Sbjct: 175 YTVVGNPYWMAPEMLNGKS-YDETVDIFSFGIVLCE-IIGQ 213 >5YV8-A nrPDB Length = 298 Score = 65.5 bits (158), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 80/307 (26%), Positives = 120/307 (39%), Gaps = 57/307 (18%) Query: 42 ATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN------ 95 + G D Q YT IG GS+GVV A + A+K + + K + Sbjct: 1 GSSGSSGDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRR 60 Query: 96 ------------------------RELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLV 131 +E+ I++KLDH N+V+L E D +Y+ Sbjct: 61 PPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNE--DHLYM--- 115 Query: 132 LDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDP 191 V E V + + L + Y L + + Y+H I HRDIKP NLL+ Sbjct: 116 ---VFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGE 172 Query: 192 DTAVLKLCDFGSAKQLVRGEPNVS-YICSRYYRAPELIFGATDYTS--SIDVWSAGCVLA 248 D + K+ DFG + + + +S + + + APE + S ++DVW+ G L Sbjct: 173 DGHI-KIADFGVSNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLY 231 Query: 249 ELLLGQPIFPGDSGVDQLVEIIK--VLGTPTREQIRE-----------MNPNYTEFKFPQ 295 + GQ F D + L IK L P + I E NP + P+ Sbjct: 232 CFVFGQCPFM-DERIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPE-SRIVVPE 289 Query: 296 IKAHPWT 302 IK HPW Sbjct: 290 IKLHPWV 296 >4X3F-A nrPDB Length = 337 Score = 65.5 bits (158), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 69/230 (30%), Positives = 106/230 (46%), Gaps = 25/230 (10%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ-----DKRFKNR---ELQIMRKLDHC 107 Y ++I G G V++A G VA+K VL+ D F R E + L+H Sbjct: 14 YRLQRLIATGGMGQVWEAVDNRLGRRVAVK-VLKSEFSSDPEFIERFRAEARTTAMLNHP 72 Query: 108 NIVRLRYFFYS--SGEKKDEVYLNLVLDYV-PETVYRVARHYSRAKQTLPVIYVKLYMYQ 164 I + + S +GE + LV++ V E + V + R L + + + Q Sbjct: 73 GIASVHDYGESQMNGEGRTAY---LVMELVNGEPLNSVLKRTGR----LSLRHALDMLEQ 125 Query: 165 LFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVS---YICSRY 221 R+L H+ G+ HRD+KP N+L+ P T +K+ DFG AK V P + + Sbjct: 126 TGRALQIAHAAGLVHRDVKPGNILITP-TGQVKITDFGIAKA-VDAAPVTQTGMVMGTAQ 183 Query: 222 YRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIK 271 Y APE G D + + DV+S G V E + G+ F GD + ++ IK Sbjct: 184 YIAPEQALG-HDASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIK 232 >3C51-A nrPDB Length = 543 Score = 65.1 bits (157), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 59/210 (28%), Positives = 103/210 (49%), Gaps = 21/210 (10%) Query: 53 EVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNR-------ELQIMRKLD 105 E + D +V+G G FG V+ ++ +G+L A KK+ + + K + E +I+ K+ Sbjct: 184 EDWFLDFRVLGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILAKVH 243 Query: 106 HCNIVRLRYFFYSSGEKKDEVYLNLVL---DYVPETVYRVARHYSRAKQTLPVIYVKLYM 162 IV L Y F E K ++ L + + + +Y V ++ + Y Sbjct: 244 SRFIVSLAYAF----ETKTDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTA--- 296 Query: 163 YQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNV-SYICSRY 221 Q+ L ++H I +RD+KP+N+LLD D V ++ D G A +L G+ Y + Sbjct: 297 -QIVSGLEHLHQRNIIYRDLKPENVLLDDDGNV-RISDLGLAVELKAGQTKTKGYAGTPG 354 Query: 222 YRAPELIFGATDYTSSIDVWSAGCVLAELL 251 + APEL+ G +Y S+D ++ G L E++ Sbjct: 355 FMAPELLLG-EEYDFSVDYFALGVTLYEMI 383 >3PPZ-A nrPDB Length = 309 Score = 65.1 bits (157), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 67/223 (30%), Positives = 109/223 (48%), Gaps = 37/223 (16%) Query: 53 EVSYTDTKV---IGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN-------RELQIMR 102 ++ + D + IG GSFG V++A+ G VA+K +L ++ F RE+ IM+ Sbjct: 33 DIPWCDLNIKEKIGAGSFGTVHRAEW--HGSDVAVK-ILMEQDFHAERVNEFLREVAIMK 89 Query: 103 KLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPE-TVYRVARHYSRAKQTLPVIYVKLY 161 +L H NIV G L++V +Y+ ++YR+ H S A++ L Sbjct: 90 RLRHPNIVLF------MGAVTQPPNLSIVTEYLSRGSLYRLL-HKSGAREQLDERRRLSM 142 Query: 162 MYQLFRSLAYIHSFG--ICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICS 219 Y + + + Y+H+ I HRD+K NLL+D V K+CDFG ++ +++ S Sbjct: 143 AYDVAKGMNYLHNRNPPIVHRDLKSPNLLVDKKYTV-KVCDFGLSRLKAS-----TFLSS 196 Query: 220 R------YYRAPELIFGATDYTSSIDVWSAGCVLAEL-LLGQP 255 + + APE++ S DV+S G +L EL L QP Sbjct: 197 KSAAGTPEWMAPEVLRDEPSNEKS-DVYSFGVILWELATLQQP 238 >5TOS-A nrPDB Length = 395 Score = 64.7 bits (156), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 62/214 (28%), Positives = 103/214 (48%), Gaps = 29/214 (13%) Query: 61 VIGNGSFGVVYQAKLCDS---------GELVAIKKVLQDKRFKNRE----LQIMRKLDHC 107 VIG G FG V++ L +S G ++A+KK+ Q+ +RE + + +L H Sbjct: 72 VIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHP 131 Query: 108 NIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFR 167 N+V+L + E + VY + + ++R ++ + LP + Sbjct: 132 NLVKLIGYCLED-EHRLLVYEFMQKGSLENHLFRRGAYF----KPLPWFLRVNVALDAAK 186 Query: 168 SLAYIHS--FGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY---- 221 LA++HS + +RDIK N+LLD D KL DFG A+ G+ +SY+ +R Sbjct: 187 GLAFLHSDPVKVIYRDIKASNILLDADYNA-KLSDFGLARDGPMGD--LSYVSTRVMGTY 243 Query: 222 -YRAPELIFGATDYTSSIDVWSAGCVLAELLLGQ 254 Y APE + + + DV+S G +L E+L G+ Sbjct: 244 GYAAPEYM-SSGHLNARSDVYSFGVLLLEILSGK 276 >3LMG-A nrPDB Length = 344 Score = 64.7 bits (156), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 58/216 (26%), Positives = 95/216 (43%), Gaps = 31/216 (14%) Query: 52 QEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIK---KVLQDKRFKNR------ELQIMR 102 +E KV+G+G FG V++ GE + I KV++DK + + + Sbjct: 29 KETELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIG 88 Query: 103 KLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYM 162 LDH +IVRL S L LV Y+P + + H + + L + + Sbjct: 89 SLDHAHIVRLLGLCPGSS-------LQLVTQYLP--LGSLLDHVRQHRGALGPQLLLNWG 139 Query: 163 YQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSA-------KQLVRGEPNVS 215 Q+ + + Y+ G+ HR++ +N+LL + V ++ DFG A KQL+ E Sbjct: 140 VQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQV-QVADFGVADLLPPDDKQLLYSEAKTP 198 Query: 216 YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELL 251 ++ + FG YT DVWS G + EL+ Sbjct: 199 I---KWMALESIHFGK--YTHQSDVWSYGVTVWELM 229 >6CTH-A nrPDB Length = 309 Score = 64.7 bits (156), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 61/202 (30%), Positives = 93/202 (46%), Gaps = 19/202 (9%) Query: 62 IGNGSFGVVYQAKLCDSGELVAIKKV----LQDKRFKNRELQIMRKLDHCNIVRLRYFFY 117 +G G FG VY+ L DS +A+KKV Q + E++I+ +L H N+V+L + + Sbjct: 23 LGEGGFGSVYRGFLRDSDTYIAVKKVSRASKQGIKEYASEVKIISRLRHKNLVKLIGWCH 82 Query: 118 SSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFG- 176 GE L LV +++ + H + K L + L +L Y+H G Sbjct: 83 ERGE------LMLVYEFMANG--SLDSHIFKGKSLLTWEVRYRIVKDLASALLYLHEEGD 134 Query: 177 --ICHRDIKPQNLLLDPDTAVLKLCDFGSAKQL--VRGEPNVSYICSRYYRAPELIFGAT 232 + HRDIK N++LD KL DFG A+ + +G + Y APE + Sbjct: 135 HCVLHRDIKTSNIMLDSSFNA-KLGDFGLARLVDHAKGLKKTLLAGTVGYMAPECLSSGK 193 Query: 233 DYTSSIDVWSAGCVLAELLLGQ 254 S DV+S G V E+ G+ Sbjct: 194 ASKES-DVYSFGVVALEIASGR 214 >4LQP-A nrPDB Length = 508 Score = 64.3 bits (155), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 45/152 (29%), Positives = 75/152 (49%), Gaps = 21/152 (13%) Query: 60 KVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNREL-------QIMRKLDHCNIVRL 112 KVIG G+FG V + D+G++ A+K +L+ + +K +L ++ D +V L Sbjct: 108 KVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKDQLAHVKAERDVLAGSDSPWVVSL 167 Query: 113 RYFFYSSGEKKDEVYLNLVLDYVP--ETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLA 170 Y F +D YL L+++++P + + + R Q + YM + ++ Sbjct: 168 YYSF------QDAQYLYLIMEFLPGGDLMTMLIRW-----QLFTEDVTRFYMAECILAIE 216 Query: 171 YIHSFGICHRDIKPQNLLLDPDTAVLKLCDFG 202 IH G HR IKP N+L+D +KL DFG Sbjct: 217 TIHKLGFIHRAIKPDNILIDI-RGHIKLSDFG 247 Score = 31.6 bits (70), Expect = 0.67, Method: Compositional matrix adjust. Identities = 16/36 (44%), Positives = 19/36 (52%), Gaps = 1/36 (2%) Query: 222 YRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIF 257 Y APE IF Y D WS G ++ E L+G P F Sbjct: 329 YIAPE-IFLYQGYGQECDWWSLGAIMYECLIGWPPF 363 >1ZWS-A nrPDB Length = 288 Score = 64.3 bits (155), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 64/244 (26%), Positives = 112/244 (45%), Gaps = 27/244 (11%) Query: 45 GQGPDRPQEVS--YTDTKVIGNGSFGVV-----------YQAKLCDSGELVAIKKVLQDK 91 G P + Q+V Y + +G+G F +V Y AK + A ++ + + Sbjct: 1 GMEPFKQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSRE 60 Query: 92 RFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQ 151 + RE+ I+R++ H N++ L + E + +V L L L E +A+ K+ Sbjct: 61 EIE-REVSILRQVLHHNVITLHDVY----ENRTDVVLILELVSGGELFDFLAQ-----KE 110 Query: 152 TLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQN-LLLDPDTAV--LKLCDFGSAKQLV 208 +L ++ Q+ + Y+H+ I H D+KP+N +LLD + + +KL DFG A ++ Sbjct: 111 SLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIE 170 Query: 209 RGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVE 268 G + + + APE++ D+WS G + LL G F GD+ + L Sbjct: 171 DGVEFKNIFGTPEFVAPEIV-NYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLAN 229 Query: 269 IIKV 272 I V Sbjct: 230 ITSV 233 >3OMV-A nrPDB Length = 307 Score = 64.3 bits (155), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 62/230 (26%), Positives = 104/230 (45%), Gaps = 44/230 (19%) Query: 62 IGNGSFGVVYQAKLCDSGEL-VAIKKVL-----QDKRFKNRELQIMRKLDHCNIVRLRYF 115 IG+GSFG VY+ K G++ V I KV+ Q + F+N E+ ++RK H NI+ Sbjct: 44 IGSGSFGTVYKGKW--HGDVAVKILKVVDPTPEQFQAFRN-EVAVLRKTRHVNIL----- 95 Query: 116 FYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFR-------- 167 L + Y+ + + + ++V+ +Q+F+ Sbjct: 96 --------------LFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQT 141 Query: 168 --SLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSA--KQLVRGEPNVSY-ICSRYY 222 + Y+H+ I HRD+K N+ L V K+ DFG A K G V S + Sbjct: 142 AQGMDYLHAKNIIHRDMKSNNIFLHEGLTV-KIGDFGLATVKSRWSGSQQVEQPTGSVLW 200 Query: 223 RAPELIFGATD--YTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEII 270 APE+I + ++ DV+S G VL EL+ G+ + + DQ++ ++ Sbjct: 201 MAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMV 250 >5IKW-A nrPDB Length = 310 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 60/219 (27%), Positives = 96/219 (43%), Gaps = 46/219 (21%) Query: 62 IGNGSFGVVYQAKLCDSGELVAIKKV----LQDKRFKNRELQIMRKLDHCNIVRLRYFFY 117 + G F V+ + G A+K++ + D RE+ IM++L Sbjct: 22 LAEGGFSTVFLVRT-HGGIRCALKRMYVNNMPDLNVCKREITIMKEL------------- 67 Query: 118 SSGEKKDEVYLNLVLDYVPETVYRVA--RHYSRAKQTLPVIYVKLY-------MYQLF-- 166 SG K YL+ ++ + + V+ V Y RA Q + + KL + Q+F Sbjct: 68 -SGHKNIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCD 126 Query: 167 --RSLAYIHSFG--ICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRG---------EPN 213 ++A +H I HRD+K +N+LL+ D LCDFGSA E Sbjct: 127 TCEAVARLHQCKTPIIHRDLKVENILLN-DGGNYVLCDFGSATNKFLNPQKDGVNVVEEE 185 Query: 214 VSYICSRYYRAPELI--FGATDYTSSIDVWSAGCVLAEL 250 + + YRAPE+I +G T+ D+W+ GC+L +L Sbjct: 186 IKKYTTLSYRAPEMINLYGGKPITTKADIWALGCLLYKL 224 >2A27-A nrPDB Length = 321 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 64/244 (26%), Positives = 112/244 (45%), Gaps = 27/244 (11%) Query: 45 GQGPDRPQEVS--YTDTKVIGNGSFGVV-----------YQAKLCDSGELVAIKKVLQDK 91 G P + Q+V Y + +G+G F +V Y AK + A ++ + + Sbjct: 1 GMEPFKQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSRE 60 Query: 92 RFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQ 151 + RE+ I+R++ H N++ L + E + +V L L L E +A+ K+ Sbjct: 61 EIE-REVSILRQVLHHNVITLHDVY----ENRTDVVLILELVSGGELFDFLAQ-----KE 110 Query: 152 TLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQN-LLLDPDTAV--LKLCDFGSAKQLV 208 +L ++ Q+ + Y+H+ I H D+KP+N +LLD + + +KL DFG A ++ Sbjct: 111 SLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIE 170 Query: 209 RGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVE 268 G + + + APE++ D+WS G + LL G F GD+ + L Sbjct: 171 DGVEFKNIFGTPEFVAPEIV-NYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLAN 229 Query: 269 IIKV 272 I V Sbjct: 230 ITAV 233 >4OW8-A nrPDB Length = 283 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 69/230 (30%), Positives = 106/230 (46%), Gaps = 25/230 (10%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ-----DKRFKNR---ELQIMRKLDHC 107 Y ++I G G V++A G VA+K VL+ D F R E + L+H Sbjct: 13 YRLQRLIATGGMGQVWEAVDNRLGRRVAVK-VLKSEFSSDPEFIERFRAEARTTAMLNHP 71 Query: 108 NIVRLRYFFYS--SGEKKDEVYLNLVLDYV-PETVYRVARHYSRAKQTLPVIYVKLYMYQ 164 I + + S +GE + LV++ V E + V + R L + + + Q Sbjct: 72 GIASVHDYGESQMNGEGRTAY---LVMELVNGEPLNSVLKRTGR----LSLRHALDMLEQ 124 Query: 165 LFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVS---YICSRY 221 R+L H+ G+ HRD+KP N+L+ P T +K+ DFG AK V P + + Sbjct: 125 TGRALQIAHAAGLVHRDVKPGNILITP-TGQVKITDFGIAKA-VDAAPVTQTGMVMGTAQ 182 Query: 222 YRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIK 271 Y APE G D + + DV+S G V E + G+ F GD + ++ IK Sbjct: 183 YIAPEQALG-HDASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIK 231 >6DBN-A nrPDB Length = 316 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 71/286 (24%), Positives = 125/286 (43%), Gaps = 46/286 (16%) Query: 62 IGNGSFGVV----YQAKLCDSGELVAIKKVLQDKRFKN-----RELQIMRKLDHCNIVRL 112 +G G FG V Y + ++GE VA+K + + + +E++I+R L H NIV+ Sbjct: 43 LGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKY 102 Query: 113 RYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYI 172 + G + L+++++P + + + K + + Y Q+ + + Y+ Sbjct: 103 KGICTEDGGNG----IKLIMEFLPSG--SLKEYLPKNKNKINLKQQLKYAVQICKGMDYL 156 Query: 173 HSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSR-------YYRAP 225 S HRD+ +N+L++ + V K+ DFG K + E + Y + ++ AP Sbjct: 157 GSRQYVHRDLAARNVLVESEHQV-KIGDFGLTKAI---ETDKEYYTVKDDRDSPVFWYAP 212 Query: 226 ELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQI---R 282 E + + Y +S DVWS G L ELL DS + +K++G PT Q+ R Sbjct: 213 ECLMQSKFYIAS-DVWSFGVTLHELLT-----YCDSDSSPMALFLKMIG-PTHGQMTVTR 265 Query: 283 EMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTAR 328 +N + P P P E L + E+ P+ R Sbjct: 266 LVNTLKEGKRLP----------CPPNCPDEVYQLMRKCWEFQPSNR 301 >5TE0-A nrPDB Length = 347 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 58/216 (26%), Positives = 99/216 (45%), Gaps = 29/216 (13%) Query: 57 TDTKVIGNGSFGVVYQAKLCDSGELVAIKKVL----QDKRFKNRELQIMRKLD-HCNIVR 111 T +V+ G F +V+ + +G A+K++ D + RE+QIMR L H NIV Sbjct: 22 TVDEVLAEGGFAIVFLVRT-SNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVG 80 Query: 112 LRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLF----R 167 ++ D + +++D+ R + + Q L + + + Q+F Sbjct: 81 YIDSSINNVSSGDVWEVLILMDFC-----RGGQVVNLMNQRLQTGFTENEVLQIFCDTCE 135 Query: 168 SLAYIHSFG--ICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRG---------EPNVSY 216 ++A +H I HRD+K +N+LL D LCDFGSA + E + Sbjct: 136 AVARLHQCKTPIIHRDLKVENILLH-DRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKK 194 Query: 217 ICSRYYRAPELI--FGATDYTSSIDVWSAGCVLAEL 250 + YRAPE++ + T+ D+W+ GC+L +L Sbjct: 195 YTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKL 230 >3GUB-A nrPDB Length = 295 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 60/237 (25%), Positives = 107/237 (45%), Gaps = 42/237 (17%) Query: 56 YTDT-KVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN-----------RELQIMRK 103 Y DT + +G+G F VV + + +G L K ++ +R K+ RE+ I+++ Sbjct: 12 YYDTGEELGSGQFAVVKKCREKSTG-LQYAAKFIKKRRTKSSRRGVSREDIEREVSILKE 70 Query: 104 LDHCNIVRLRYFFYSSGEKKDEVYL-------NLVLDYVPETVYRVARHYSRAKQTLPVI 156 + H N++ L + E K +V L + D++ E K++L Sbjct: 71 IQHPNVITLHEVY----ENKTDVILIGELVAGGELFDFLAE------------KESLTEE 114 Query: 157 YVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAV----LKLCDFGSAKQLVRGEP 212 ++ Q+ + Y+HS I H D+KP+N++L D V +K+ DFG A ++ G Sbjct: 115 EATEFLKQILNGVYYLHSLQIAHFDLKPENIML-LDRNVPKPRIKIIDFGLAHKIDFGNE 173 Query: 213 NVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEI 269 + + + APE++ D+WS G + LL G F GD+ + L + Sbjct: 174 FKNIFGTPEFVAPEIV-NYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANV 229 >6GQK-A nrPDB Length = 328 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 77/276 (27%), Positives = 115/276 (41%), Gaps = 55/276 (19%) Query: 60 KVIGNGSFGVVYQAKL-----CDSGELVAIKKVLQDKRFKNRE-----LQIMRKL-DHCN 108 K +G G+FG V +A D+ VA+K + RE L+++ L +H N Sbjct: 47 KTLGAGAFGKVVEATAQGLIKSDAAMTVAVKMLKPSAHSTEREALMSELKVLSYLGNHEN 106 Query: 109 IVRL--------------RYFFYSS-----GEKKDEVYLNLVLDYVPETVYRVARHYSRA 149 IV L Y Y K+DE +VP Y+VA Sbjct: 107 IVNLLGACTHGGPTLVITEYCCYGDLLNFLRRKRDE--------FVP---YKVAPE-DLY 154 Query: 150 KQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVR 209 K L + ++ + YQ+ + +A++ S HRD+ +N+LL + K+CDFG A+ + Sbjct: 155 KDFLTLEHLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGN-ITKICDFGLARDIKN 213 Query: 210 GEPNVSYICSRY---YRAPELIFGATDYTSSIDVWSAGCVLAELL-LGQPIFPGDSGVDQ 265 V +R + APE IF + YT DVWS G L EL LG +PG + Sbjct: 214 DSNYVDKGNARLPVKWMAPESIFNSV-YTFESDVWSYGIFLWELFSLGSSPYPGMPVDSK 272 Query: 266 LVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPW 301 ++IK E R +P Y + I W Sbjct: 273 FYKMIK-------EGFRMSSPEYAPAEMYDIMKTCW 301 >4H1J-A nrPDB Length = 293 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 64/213 (30%), Positives = 102/213 (47%), Gaps = 27/213 (12%) Query: 59 TKVIGNGSFGVVYQAKLCD-SGEL--VAIKKVLQDKRFKNRE-----LQIMRKLDHCNIV 110 +++G G FG VY+ + GE VA+K +D N+E IM+ LDH +IV Sbjct: 29 NRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHIV 88 Query: 111 RLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHY-SRAKQTLPVIYVKLYMYQLFRSL 169 +L +E ++++ P Y HY R K +L V+ + LY Q+ +++ Sbjct: 89 KLIGII-------EEEPTWIIMELYP---YGELGHYLERNKNSLKVLTLVLYSLQICKAM 138 Query: 170 AYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY---YRAPE 226 AY+ S HRDI +N+L+ V KL DFG ++ + E +R + +PE Sbjct: 139 AYLESINCVHRDIAVRNILVASPECV-KLGDFGLSRY-IEDEDYYKASVTRLPIKWMSPE 196 Query: 227 LIFGATDYTSSIDVWSAGCVLAELL-LG-QPIF 257 I +T++ DVW + E+L G QP F Sbjct: 197 SI-NFRRFTTASDVWMFAVCMWEILSFGKQPFF 228 >6B2Q-A nrPDB Length = 317 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 69/230 (30%), Positives = 106/230 (46%), Gaps = 25/230 (10%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ-----DKRFKNR---ELQIMRKLDHC 107 Y ++I G G V++A G VA+K VL+ D F R E + L+H Sbjct: 34 YRLQRLIATGGMGQVWEAVDNRLGRRVAVK-VLKSEFSSDPEFIERFRAEARTTAMLNHP 92 Query: 108 NIVRLRYFFYS--SGEKKDEVYLNLVLDYV-PETVYRVARHYSRAKQTLPVIYVKLYMYQ 164 I + + S +GE + LV++ V E + V + R L + + + Q Sbjct: 93 GIASVHDYGESQMNGEGRTAY---LVMELVNGEPLNSVLKRTGR----LSLRHALDMLEQ 145 Query: 165 LFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVS---YICSRY 221 R+L H+ G+ HRD+KP N+L+ P T +K+ DFG AK V P + + Sbjct: 146 TGRALQIAHAAGLVHRDVKPGNILITP-TGQVKITDFGIAKA-VDAAPVTQTGMVMGTAQ 203 Query: 222 YRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIK 271 Y APE G D + + DV+S G V E + G+ F GD + ++ IK Sbjct: 204 YIAPEQALG-HDASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIK 252 >2RIO-A nrPDB Length = 434 Score = 62.4 bits (150), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 84/316 (26%), Positives = 138/316 (43%), Gaps = 72/316 (22%) Query: 60 KVIGNGSFG-VVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKL----DHCNIVRLRY 114 K++G GS G VV+Q G VA+K++L D F + L ++ L DH N++R Sbjct: 21 KILGYGSSGTVVFQGSF--QGRPVAVKRMLID--FCDIALMEIKLLTESDDHPNVIR--- 73 Query: 115 FFYSSGEKKDEVYL-----NLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 169 +Y S +Y+ NL L + E+ + K+ P+ ++ Q+ + Sbjct: 74 -YYCSETTDRFLYIALELCNLNLQDLVESKNVSDENLKLQKEYNPISLLR----QIASGV 128 Query: 170 AYIHSFGICHRDIKPQNLLL--------DPDTAV----LKLCDFGSAKQLVRGEPNVSYI 217 A++HS I HRD+KPQN+L+ D T + + DFG K+L G+ + Sbjct: 129 AHLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRTN 188 Query: 218 CSR-----YYRAPELIFGATD------YTSSIDVWSAGCVLAELL-LGQPIFPGDSGVDQ 265 + +RAPEL+ + + T SID++S GCV +L G+ F GD Sbjct: 189 LNNPSGTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPF-GD----- 242 Query: 266 LVEIIKVLGTPTREQIREMNPNYTEFKFPQIKA-HPWTKVFRPRTPPEAIALCSRLLEYT 324 + RE N F ++K H + + EA L S+++++ Sbjct: 243 -------------KYSRESNIIRGIFSLDEMKCLHDRSLI------AEATDLISQMIDHD 283 Query: 325 PTARLTPLEACAHSFF 340 P R T ++ H F Sbjct: 284 PLKRPTAMKVLRHPLF 299 >2PZI-A nrPDB Length = 681 Score = 61.6 bits (148), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 55/198 (27%), Positives = 98/198 (49%), Gaps = 29/198 (14%) Query: 99 QIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAK-QTLPVIY 157 Q + ++ H +IV++ F + D V +V++YV + R+K Q LPV Sbjct: 131 QFLAEVVHPSIVQIFNFVEHTDRHGDPVGY-IVMEYVG------GQSLKRSKGQKLPVAE 183 Query: 158 VKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQL-----VRGEP 212 Y+ ++ +L+Y+HS G+ + D+KP+N++L + LKL D G+ ++ + G P Sbjct: 184 AIAYLLEILPALSYLHSIGLVYNDLKPENIMLTEEQ--LKLIDLGAVSRINSFGYLYGTP 241 Query: 213 NVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVE---I 269 ++APE++ T T + D+++ G LA L L P G VD L E + Sbjct: 242 G--------FQAPEIV--RTGPTVATDIYTVGRTLAALTLDLPTRNGRY-VDGLPEDDPV 290 Query: 270 IKVLGTPTREQIREMNPN 287 +K + R R ++P+ Sbjct: 291 LKTYDSYGRLLRRAIDPD 308 >2YAB-A nrPDB Length = 361 Score = 61.2 bits (147), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 59/225 (26%), Positives = 105/225 (46%), Gaps = 25/225 (11%) Query: 62 IGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFK-----------NRELQIMRKLDHCNIV 110 +G+G F +V + + +G L K ++ ++ + RE+ I+R++ H NI+ Sbjct: 20 LGSGQFAIVKKCREKSTG-LEYAAKFIKKRQSRASRRGVCREEIEREVSILRQVLHPNII 78 Query: 111 RLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLA 170 L + E + +V L L L E +A+ K++L ++ Q+ + Sbjct: 79 TLHDVY----ENRTDVVLILELVSGGELFDFLAQ-----KESLSEEEATSFIKQILDGVN 129 Query: 171 YIHSFGICHRDIKPQN-LLLDPDTAV--LKLCDFGSAKQLVRGEPNVSYICSRYYRAPEL 227 Y+H+ I H D+KP+N +LLD + + +KL DFG A ++ G + + + APE+ Sbjct: 130 YLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEI 189 Query: 228 IFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKV 272 + D+WS G + LL G F GD+ + L I V Sbjct: 190 V-NYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAV 233 >3VHK-A nrPDB Length = 368 Score = 61.2 bits (147), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 47/156 (30%), Positives = 75/156 (48%), Gaps = 13/156 (8%) Query: 150 KQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVR 209 K L + ++ Y +Q+ + + ++ S HRD+ +N+LL + V+K+CDFG A+ + + Sbjct: 194 KDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLS-EKNVVKICDFGLARDIYK 252 Query: 210 GEPNVSYICSRY---YRAPELIFGATDYTSSIDVWSAGCVLAELL-LGQPIFPGDSGVDQ 265 V +R + APE IF YT DVWS G +L E+ LG +PG Sbjct: 253 DPDYVRKGDARLPLKWMAPETIFDRV-YTIQSDVWSFGVLLWEIFSLGASPYPG------ 305 Query: 266 LVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPW 301 V+I + +E R P+YT + Q W Sbjct: 306 -VKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCW 340 >4Y12-A nrPDB Length = 375 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 54/183 (29%), Positives = 91/183 (49%), Gaps = 26/183 (14%) Query: 99 QIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAK-QTLPVIY 157 Q + ++ H +IV++ F + D V +V++YV + R+K Q LPV Sbjct: 170 QFLAEVVHPSIVQIFNFVEHTDRHGDPVGY-IVMEYVG------GQSLKRSKGQKLPVAE 222 Query: 158 VKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQL-----VRGEP 212 Y+ ++ +L+Y+HS G+ + D+KP+N++L + LKL D G+ ++ + G P Sbjct: 223 AIAYLLEILPALSYLHSIGLVYNDLKPENIMLTEEQ--LKLIDLGAVSRINSFGYLYGTP 280 Query: 213 NVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKV 272 ++APE++ T T + D+++ G LA L L P G VD L E V Sbjct: 281 G--------FQAPEIV--RTGPTVATDIYTVGRTLAALTLDLPTRNGRY-VDGLPEDDPV 329 Query: 273 LGT 275 L T Sbjct: 330 LKT 332 >3CJF-A nrPDB Length = 309 Score = 60.5 bits (145), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 47/156 (30%), Positives = 75/156 (48%), Gaps = 13/156 (8%) Query: 150 KQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVR 209 K L + ++ Y +Q+ + + ++ S HRD+ +N+LL + V+K+CDFG A+ + + Sbjct: 138 KDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLS-EKNVVKICDFGLARDIYK 196 Query: 210 GEPNVSYICSRY---YRAPELIFGATDYTSSIDVWSAGCVLAELL-LGQPIFPGDSGVDQ 265 V +R + APE IF YT DVWS G +L E+ LG +PG Sbjct: 197 DPDYVRKGDARLPLKWMAPETIFDRV-YTIQSDVWSFGVLLWEIFSLGASPYPG------ 249 Query: 266 LVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPW 301 V+I + +E R P+YT + Q W Sbjct: 250 -VKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCW 284 >4EBW-A nrPDB Length = 304 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 64/207 (30%), Positives = 98/207 (47%), Gaps = 29/207 (14%) Query: 60 KVIGNGSFGVVYQAKLC---DSGELVAIK--KVLQDKRFKNRELQ---IMRKLDHCNIVR 111 + IG G FG V+Q + VAIK K + + LQ MR+ DH +IV+ Sbjct: 44 RCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVK 103 Query: 112 LRYFFYSSGEKKDEVYLNLVLDYVPET-VYRVARHYSRAKQTLPVIYVKLYMYQLFRSLA 170 L ++ V++ + L + E + R YS L + + LY YQL +LA Sbjct: 104 LIGVI-----TENPVWIIMELCTLGELRSFLQVRKYS-----LDLASLILYAYQLSTALA 153 Query: 171 YIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSR-----YYRAP 225 Y+ S HRDI +N+L+ + V KL DFG ++ + E + Y S+ + AP Sbjct: 154 YLESKRFVHRDIAARNVLVSSNDCV-KLGDFGLSRYM---EDSTYYKASKGKLPIKWMAP 209 Query: 226 ELIFGATDYTSSIDVWSAGCVLAELLL 252 E I +TS+ DVW G + E+L+ Sbjct: 210 ESI-NFRRFTSASDVWMFGVCMWEILM 235 >5LPZ-A nrPDB Length = 332 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 68/236 (28%), Positives = 111/236 (47%), Gaps = 35/236 (14%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ-----DKRFKNRELQIMRKLDHCNI 109 + + +IG+G FG VY+A L D G VAIKK++ D+ F E++ + K+ H N+ Sbjct: 18 GFHNDSLIGSGGFGDVYKAILKD-GSAVAIKKLIHVSGQGDREFMA-EMETIGKIKHRNL 75 Query: 110 VRLRYFFYSSGEKKDEVYLNLVLDYVP-ETVYRVARHYSRAKQTLPVIYVKLYMYQLFRS 168 V L + E+ LV +++ ++ V +A L + R Sbjct: 76 VPLLGYCKVGDERL------LVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARG 129 Query: 169 LAYIH---SFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVS---------Y 216 LA++H S I HRD+K N+LLD + ++ DFG A+ + + ++S Y Sbjct: 130 LAFLHHNCSPHIIHRDMKSSNVLLDENLEA-RVSDFGMARLMSAMDTHLSVSTLAGTPGY 188 Query: 217 ICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQ-PIFPGDSGVDQLVEIIK 271 + YY++ ++ DV+S G VL ELL G+ P D G + LV +K Sbjct: 189 VPPEYYQSFRC-------STKGDVYSYGVVLLELLTGKRPTDSPDFGDNNLVGWVK 237 >4PWN-A nrPDB Length = 274 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 56/201 (27%), Positives = 95/201 (47%), Gaps = 23/201 (11%) Query: 62 IGNGSFGVVYQAKLCDSGELVAIKKVLQDK--------RFKNRELQIMRKLDHCNIVRLR 113 IG GSF VY+ ++ VA + LQD+ RFK E ++++ L H NIVR Sbjct: 18 IGRGSFKTVYKGLDTETTVEVAWCE-LQDRKLTKSERQRFKE-EAEMLKGLQHPNIVR-- 73 Query: 114 YFFYSSGEK--KDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAY 171 FY S E K + + LV + + + Y + + + + ++ + Q+ + L + Sbjct: 74 --FYDSWESTVKGKKCIVLVTELMTSGTLKT---YLKRFKVMKIKVLRSWCRQILKGLQF 128 Query: 172 IHSFG--ICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIF 229 +H+ I HRD+K N+ + T +K+ D G A R S I + + APE+ Sbjct: 129 LHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLEKRASFAKSVIGTPEFMAPEMY- 187 Query: 230 GATDYTSSIDVWSAGCVLAEL 250 Y S+DV++ G + E+ Sbjct: 188 -EEKYDESVDVYAFGMCMLEM 207 >3QD2-B nrPDB Length = 332 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 69/266 (25%), Positives = 113/266 (42%), Gaps = 81/266 (30%) Query: 60 KVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNREL---QIMR------KLDHCNIV 110 + +G G FGVV++AK AIK++ R NREL ++MR KL+H IV Sbjct: 12 QCMGRGGFGVVFEAKNKVDDCNYAIKRI----RLPNRELAREKVMREVKALAKLEHPGIV 67 Query: 111 RLRYFFYSS-----GEKKDEVYL-NLVLDY---------VPETVYRVARHYSRAKQTL-- 153 R + + E+ DE++L + D+ P R +S K T+ Sbjct: 68 RYFNAWLETPPEKWQEEMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFS-TKNTVGQ 126 Query: 154 -----PVIYVKLYM------------------------------YQLFRSLAYIHSFGIC 178 P +Y+ + M Q+ ++ ++HS G+ Sbjct: 127 LQPSSPKVYLYIQMQLCRKENLKDWMNRRCSLEDREHGVCLHIFIQIAEAVEFLHSKGLM 186 Query: 179 HRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGE-------PNVSY------ICSRYYRAP 225 HRD+KP N+ D V+K+ DFG + + E P +Y + ++ Y +P Sbjct: 187 HRDLKPSNIFFTMDD-VVKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQVGTKLYMSP 245 Query: 226 ELIFGATDYTSSIDVWSAGCVLAELL 251 E I G +Y+ +D++S G +L ELL Sbjct: 246 EQIHG-NNYSHKVDIFSLGLILFELL 270 >5LPV-A nrPDB Length = 296 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 68/236 (28%), Positives = 111/236 (47%), Gaps = 35/236 (14%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ-----DKRFKNRELQIMRKLDHCNI 109 + + +IG+G FG VY+A L D G VAIKK++ D+ F E++ + K+ H N+ Sbjct: 18 GFHNDSLIGSGGFGDVYKAILKD-GSAVAIKKLIHVSGQGDREFMA-EMETIGKIKHRNL 75 Query: 110 VRLRYFFYSSGEKKDEVYLNLVLDYVP-ETVYRVARHYSRAKQTLPVIYVKLYMYQLFRS 168 V L + E+ LV +++ ++ V +A L + R Sbjct: 76 VPLLGYCKVGDERL------LVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARG 129 Query: 169 LAYIH---SFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVS---------Y 216 LA++H S I HRD+K N+LLD + ++ DFG A+ + + ++S Y Sbjct: 130 LAFLHHNCSPHIIHRDMKSSNVLLDENLEA-RVSDFGMARLMSAMDTHLSVSTLAGTPGY 188 Query: 217 ICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQ-PIFPGDSGVDQLVEIIK 271 + YY++ ++ DV+S G VL ELL G+ P D G + LV +K Sbjct: 189 VPPEYYQSFRC-------STKGDVYSYGVVLLELLTGKRPTDSPDFGDNNLVGWVK 237 >2J0K-A nrPDB Length = 656 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 62/207 (29%), Positives = 100/207 (48%), Gaps = 29/207 (14%) Query: 60 KVIGNGSFGVVYQAKLC---DSGELVAIK--KVLQDKRFKNRELQ---IMRKLDHCNIVR 111 + IG G FG V+Q + VAIK K + + LQ MR+ DH +IV+ Sbjct: 396 RCIGEGQFGDVHQGIYMSPENPAMAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVK 455 Query: 112 LRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQ-TLPVIYVKLYMYQLFRSLA 170 L ++ V++ + L + E R + + ++ +L + + LY YQL +LA Sbjct: 456 LIGVI-----TENPVWIIMELCTLGEL-----RSFLQVRKFSLDLASLILYAYQLSTALA 505 Query: 171 YIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSR-----YYRAP 225 Y+ S HRDI +N+L+ T +KL DFG ++ + E + Y S+ + AP Sbjct: 506 YLESKRFVHRDIAARNVLVSA-TDCVKLGDFGLSRYM---EDSTYYKASKGKLPIKWMAP 561 Query: 226 ELIFGATDYTSSIDVWSAGCVLAELLL 252 E I +TS+ DVW G + E+L+ Sbjct: 562 ESI-NFRRFTSASDVWMFGVCMWEILM 587 >6CKI-A nrPDB Length = 316 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 40/111 (36%), Positives = 59/111 (53%), Gaps = 14/111 (12%) Query: 168 SLAYIHSFGICHRDIKPQNLLLDPDTAV--LKLCDFGSAKQL-VRGE------PNVSYIC 218 +L ++H+ GI HRD+KP+N+L + V +K+CDFG + + G+ P + C Sbjct: 123 ALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPELLTPC 182 Query: 219 -SRYYRAPELIFG----ATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVD 264 S Y APE++ A+ Y D+WS G +L LL G P F G G D Sbjct: 183 GSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSD 233 >4F0G-A nrPDB Length = 287 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 68/228 (29%), Positives = 110/228 (48%), Gaps = 42/228 (18%) Query: 53 EVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKK-VLQD--------KRFK--NRELQIM 101 E+ Y K IG G FG+V++ +L +VAIK +L D ++F+ RE+ IM Sbjct: 20 EIEYE--KQIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQREVFIM 77 Query: 102 RKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSR-AKQTLPVIY-VK 159 L+H NIV+L ++ +V+++VP Y R + P+ + VK Sbjct: 78 SNLNHPNIVKLYGLMHNPP--------RMVMEFVP-----CGDLYHRLLDKAHPIKWSVK 124 Query: 160 L-YMYQLFRSLAYIHSFG--ICHRDIKPQNLL---LDPDTAVL-KLCDFGSAKQLVRGEP 212 L M + + Y+ + I HRD++ N+ LD + V K+ DFG ++Q V Sbjct: 125 LRLMLDIALGIEYMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQSVH--- 181 Query: 213 NVSYICSRY-YRAPELIFGATD--YTSSIDVWSAGCVLAELLLGQPIF 257 +VS + + + APE I GA + YT D +S +L +L G+ F Sbjct: 182 SVSGLLGNFQWMAPETI-GAEEESYTEKADTYSFAMILYTILTGEGPF 228 >3SXS-A nrPDB Length = 268 Score = 58.5 bits (140), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 59/203 (29%), Positives = 100/203 (49%), Gaps = 22/203 (10%) Query: 57 TDTKVIGNGSFGVVYQAKLCDSGEL-VAIKKVLQDKRFKN---RELQIMRKLDHCNIVRL 112 T K +G+G FGVV K G+ VA+K + + ++ +E Q M KL H +V+ Sbjct: 11 TLLKELGSGQFGVVKLGKW--KGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVK- 67 Query: 113 RYFFYSSGEKKDEVYLNLVLDYVPE-TVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAY 171 FY K+ +Y+ V +Y+ + R S K P +++ Y + +A+ Sbjct: 68 ---FYGVCSKEYPIYI--VTEYISNGCLLNYLR--SHGKGLEPSQLLEM-CYDVCEGMAF 119 Query: 172 IHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY---YRAPELI 228 + S HRD+ +N L+D D V K+ DFG + V + VS + +++ + APE + Sbjct: 120 LESHQFIHRDLAARNCLVDRDLCV-KVSDFGMTR-YVLDDQYVSSVGTKFPVKWSAPE-V 176 Query: 229 FGATDYTSSIDVWSAGCVLAELL 251 F Y+S DVW+ G ++ E+ Sbjct: 177 FHYFKYSSKSDVWAFGILMWEVF 199 >6GVJ-A nrPDB Length = 429 Score = 58.5 bits (140), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 77/321 (23%), Positives = 134/321 (41%), Gaps = 64/321 (19%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDK-------RFKNRELQIMRKLDHCN 108 Y+ K IG+G V+Q L + ++ AIK V ++ ++N E+ + KL + Sbjct: 146 YSILKQIGSGGSSKVFQV-LNEKKQIYAIKYVNLEEADNQTLDSYRN-EIAYLNKLQQHS 203 Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRS 168 +R + Y ++ Y+ +V+ E + + K+++ K Y + + Sbjct: 204 DKIIRLYDYEITDQ----YIYMVM----ECGNIDLNSWLKKKKSIDPWERKSYWKNMLEA 255 Query: 169 LAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNV---SYICSRYYRAP 225 + IH GI H D+KP N L+ +LKL DFG A Q+ +V S + + Y P Sbjct: 256 VHTIHQHGIVHSDLKPANFLI--VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPP 313 Query: 226 ELIFGATDYTSS-------------IDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKV 272 E I D +SS DVWS GC+L + G+ P ++Q+ ++ + Sbjct: 314 EAI---KDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKT--PFQQIINQISKLHAI 368 Query: 273 LGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPL 332 + +PN+ E +FP I P + + C L+ P R++ Sbjct: 369 I-----------DPNH-EIEFPDI----------PEKDLQDVLKCC--LKRDPKQRISIP 404 Query: 333 EACAHSFFDELRDPNVKLPNG 353 E AH + P ++ G Sbjct: 405 ELLAHPYVQIQTHPVNQMAKG 425 >4YHJ-A nrPDB Length = 584 Score = 58.5 bits (140), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 68/282 (24%), Positives = 120/282 (42%), Gaps = 41/282 (14%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN-------RELQIMRKLDHC 107 ++ +V+G G FG V ++ +G++ A KK+ + + K E +I+ K+ Sbjct: 186 TFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSR 245 Query: 108 NIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFR 167 +V L Y + E KD + L L + + + + Y+ Y +L Sbjct: 246 FVVSLAYAY----ETKDALCLVLTIMNGGDLKFHI---YNLGNPGFDEQRAVFYAAELCC 298 Query: 168 SLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPEL 227 L + I +RD+KP+N+LLD D +++ D G A ++ G+ + + Y APE+ Sbjct: 299 GLEDLQRERIVYRDLKPENILLD-DRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEV 357 Query: 228 IFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPN 287 + YT S D W GC++ E++ G F KV ++I+ Sbjct: 358 V-NNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKE--------KVKWEEVDQRIKNDTEE 408 Query: 288 YTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARL 329 Y+E KF + +A ++C LL P+ RL Sbjct: 409 YSE-KFSE----------------DAKSICRMLLTKNPSKRL 433 >5MJB-A nrPDB Length = 305 Score = 58.5 bits (140), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 59/208 (28%), Positives = 89/208 (42%), Gaps = 28/208 (13%) Query: 60 KVIGNGSFGVVYQAKLCDSGE---LVAIKKVLQDKRFKNR-----ELQIMRKLDHCNIVR 111 +VIG G FG VY+ +L G+ VAIK + K R E IM + DH NI+R Sbjct: 32 EVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHRNIIR 91 Query: 112 LRYFFYSSGEKK--DEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 169 L S E N LD + VI + + + + Sbjct: 92 LEGVVTKSRPVMIITEFMENCALD----------SFLRQNDGQFTVIQLVGMLRGIAAGM 141 Query: 170 AYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSR------YYR 223 Y+ HRD+ +N+L++ + V K+ DFG ++ L + +Y S + Sbjct: 142 KYLSEMNYVHRDLAARNILVNSNL-VCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWT 200 Query: 224 APELIFGATDYTSSIDVWSAGCVLAELL 251 APE I +TS+ DVWS G V+ E++ Sbjct: 201 APEAI-AYRKFTSASDVWSYGIVMWEVM 227 >2ZMD-A nrPDB Length = 390 Score = 58.5 bits (140), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 89/375 (23%), Positives = 153/375 (40%), Gaps = 66/375 (17%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDK-------RFKNRELQIMRKLDHCN 108 Y+ K IG+G V+Q L + ++ AIK V ++ ++N E+ + KL + Sbjct: 58 YSILKQIGSGGSSKVFQV-LNEKKQIYAIKYVNLEEADNQTLDSYRN-EIAYLNKLQQHS 115 Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRS 168 +R + Y ++ Y+ +V+ E + + K+++ K Y + + Sbjct: 116 DKIIRLYDYEITDQ----YIYMVM----ECGNIDLNSWLKKKKSIDPWERKSYWKNMLEA 167 Query: 169 LAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNV---SYICSRYYRAP 225 + IH GI H D+KP N L+ +LKL DFG A Q+ +V S + + Y P Sbjct: 168 VHTIHQHGIVHSDLKPANFLI--VDGMLKLIDFGIANQMQPDTTSVVKDSQVGAVNYMPP 225 Query: 226 ELIFGATDYTSS-------------IDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKV 272 E I D +SS DVWS GC+L + G+ F Q++ I Sbjct: 226 EAI---KDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF------QQIINQISK 276 Query: 273 LGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPL 332 L ++PN+ E +FP I P + + C L+ P R++ Sbjct: 277 LHAI-------IDPNH-EIEFPDI----------PEKDLQDVLKC--CLKRDPKQRISIP 316 Query: 333 EACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASPPA 392 E AH + P ++ G T + Q + N P +IL + + + Sbjct: 317 ELLAHPYVQIQTHPVNQMAKGT-TEEMKYVLGQLVGLNSP-NSILKAAKTLYEHYSGGES 374 Query: 393 NATAASDTNAGDRGQ 407 + +++S T RG+ Sbjct: 375 HNSSSSKTFEKKRGK 389 >4PDO-A nrPDB Length = 299 Score = 58.5 bits (140), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 58/209 (27%), Positives = 94/209 (44%), Gaps = 25/209 (11%) Query: 57 TDTKVIGNGSFGVVYQAKL-CDSGEL---VAIKKVLQDKRFKNR-----ELQIMRKLDHC 107 T KVIG G FG VY+ L SG+ VAIK + K R E IM + H Sbjct: 37 TRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFSHH 96 Query: 108 NIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFR 167 NI+RL G + ++ +Y+ + + V+ + + + Sbjct: 97 NIIRL------EGVISKYKPMMIITEYMENGA--LDKFLREKDGEFSVLQLVGMLRGIAA 148 Query: 168 SLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSR-----YY 222 + Y+ + HRD+ +N+L++ + V K+ DFG ++ L +P +Y S + Sbjct: 149 GMKYLANMNYVHRDLAARNILVNSNL-VCKVSDFGLSRVL-EDDPEATYTTSGGKIPIRW 206 Query: 223 RAPELIFGATDYTSSIDVWSAGCVLAELL 251 APE I +TS+ DVWS G V+ E++ Sbjct: 207 TAPEAI-SYRKFTSASDVWSFGIVMWEVM 234 >4CRS-A nrPDB Length = 341 Score = 58.5 bits (140), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 89/340 (26%), Positives = 141/340 (41%), Gaps = 61/340 (17%) Query: 61 VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIM----RKLDHCNIVRLRYF- 115 V+ G FG V A+ ++ E+ AIK + + E+ + R + N VR + Sbjct: 19 VLLRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLV 78 Query: 116 -FYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHS 174 ++ + K+ V V++Y + H + V Y + L Y+H Sbjct: 79 NLFACFQTKEHV--CFVMEYAAGGDLMMHIHTDVFSEPRAVFYAACVVL----GLQYLHE 132 Query: 175 FGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ-LVRGEPNVSYICSRYYRAPELIFGATD 233 I +RD+K NLLLD + V K+ DFG K+ + G+ ++ + + APE++ T Sbjct: 133 HKIVYRDLKLDNLLLDTEGFV-KIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVL-TETS 190 Query: 234 YTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKF 293 YT ++D W G ++ E+L+G+ FPGD + I+ E ++ Sbjct: 191 YTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVN-----------------DEVRY 233 Query: 294 PQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACA-----HSFF-----DEL 343 P+ + EAI++ RLL P RL E A H FF L Sbjct: 234 PRFLS------------TEAISIMRRLLRRNPERRLGASEKDAEDVKKHPFFRLIDWSAL 281 Query: 344 RDPNVK---LPNGRDTPALFNFTTQELSSNPPLATILIPP 380 D VK +P R + NF E +S P IL PP Sbjct: 282 MDKKVKPPFIPTIRGREDVSNF-DDEFTSEAP---ILTPP 317 >6J5U-C nrPDB Length = 426 Score = 58.2 bits (139), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 61/230 (26%), Positives = 102/230 (44%), Gaps = 29/230 (12%) Query: 55 SYTDTKVIGNGSFGVVYQ---------AKLCDSGELVAIKKV----LQDKRFKNRELQIM 101 ++ ++G G FG V++ A SG +VA+K++ Q + E+ + Sbjct: 85 NFRQDNLLGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQLKPEGFQGHKEWLTEVNYL 144 Query: 102 RKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARH-YSRAKQTLPVIYVKL 160 +L H N+V L + + GE + VY +++P+ + H + R Q L Sbjct: 145 GQLSHPNLVLL-VGYCAEGENRLLVY-----EFMPKG--SLENHLFRRGAQPLTWAIRMK 196 Query: 161 YMYQLFRSLAYIHSFG--ICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEP---NVS 215 + L ++H + +RD K N+LLD D KL DFG AK G+ + Sbjct: 197 VAVGAAKGLTFLHEAKSQVIYRDFKAANILLDADFNA-KLSDFGLAKAGPTGDNTHVSTK 255 Query: 216 YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQ 265 I + Y APE + T+ DV+S G VL EL+ G+ +G ++ Sbjct: 256 VIGTHGYAAPEYV-ATGRLTAKSDVYSFGVVLLELISGRRAMDNSNGGNE 304 >5UIU-A nrPDB Length = 323 Score = 57.8 bits (138), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 61/207 (29%), Positives = 100/207 (48%), Gaps = 26/207 (12%) Query: 62 IGNGSFGVVYQAKLCDSGELVAIKKVL--------QDKRFKNRELQIMRKLDHCNIVRLR 113 +G G FGVVY+ + ++ VA+KK+ + K+ ++E+++M K H N+V L Sbjct: 55 MGEGGFGVVYKGYVNNT--TVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVEL- 111 Query: 114 YFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIY-VKLYMYQ-LFRSLAY 171 F S G+ L LV Y+P + S T P+ + ++ + Q + + Sbjct: 112 LGFSSDGDD-----LCLVYVYMPNG--SLLDRLSCLDGTPPLSWHMRCKIAQGAANGINF 164 Query: 172 IHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNV---SYICSRYYRAPELI 228 +H HRDIK N+LLD + K+ DFG A+ + V + + Y APE + Sbjct: 165 LHENHHIHRDIKSANILLD-EAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL 223 Query: 229 FGATDYTSSIDVWSAGCVLAELLLGQP 255 G + T D++S G VL E++ G P Sbjct: 224 RG--EITPKSDIYSFGVVLLEIITGLP 248 >5O2C-A nrPDB Length = 380 Score = 57.8 bits (138), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 57/201 (28%), Positives = 97/201 (48%), Gaps = 24/201 (11%) Query: 62 IGNGSFGVVYQAKLCDSGELVAIKKVLQDK--------RFKNRELQIMRKLDHCNIVRLR 113 +G G+F VY+ ++ VA + LQD+ RFK E ++++ L H NIVR Sbjct: 33 LGRGAFKTVYKGLDTETWVEVAWCE-LQDRKLTKAEQQRFKE-EAEMLKGLQHPNIVR-- 88 Query: 114 YFFYSSGEK--KDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAY 171 FY S E K + + LV + + + + R K P + ++ + Q+ + L + Sbjct: 89 --FYDSWESILKGKKCIVLVTELMTSGTLKT--YLKRFKVMKPKV-LRSWCRQILKGLQF 143 Query: 172 IHSFG--ICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIF 229 +H+ I HRD+K N+ + T +K+ D G A L+R S I + + APE+ Sbjct: 144 LHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLA-TLMRTSFAKSVIGTPEFMAPEMY- 201 Query: 230 GATDYTSSIDVWSAGCVLAEL 250 Y S+DV++ G + E+ Sbjct: 202 -EEHYDESVDVYAFGMCMLEM 221 >3G0E-A nrPDB Length = 336 Score = 57.8 bits (138), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 83/320 (25%), Positives = 130/320 (40%), Gaps = 49/320 (15%) Query: 15 KPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGP-DRPQEV---SYTDTKVIGNGSFGVV 70 K +Q+P KV + +G+ V P Q P D E + K +G G+FG V Sbjct: 5 KYLQKPMYEVQWKVVEEINGNNY--VYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKV 62 Query: 71 YQAKL-----CDSGELVAIKKV-----LQDKRFKNRELQIMRKL-DHCNIVRLRYFFYSS 119 +A D+ VA+K + L ++ EL+++ L +H NIV L Sbjct: 63 VEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIG 122 Query: 120 GEK---KDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKL-----------YMYQL 165 G + +L+++ R R +T P I + YQ+ Sbjct: 123 GPTLVITEYCCYGDLLNFL-----RRKRDSFICSKTSPAIMEDDELALDLEDLLSFSYQV 177 Query: 166 FRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY---Y 222 + +A++ S HRD+ +N+LL + K+CDFG A+ + V +R + Sbjct: 178 AKGMAFLASKNCIHRDLAARNILLT-HGRITKICDFGLARDIKNDSNYVVKGNARLPVKW 236 Query: 223 RAPELIFGATDYTSSIDVWSAGCVLAELL-LGQPIFPGDSGVDQLVEIIKVLGTPTREQI 281 APE IF YT DVWS G L EL LG +PG + ++IK E Sbjct: 237 MAPESIFNCV-YTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIK-------EGF 288 Query: 282 REMNPNYTEFKFPQIKAHPW 301 R ++P + + I W Sbjct: 289 RMLSPEHAPAEMYDIMKTCW 308 >2PMN-X nrPDB Length = 348 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 54/200 (27%), Positives = 88/200 (44%), Gaps = 18/200 (9%) Query: 153 LPVIYVKLYMYQLFRSLAYIHS-FGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGE 211 +P+ +K + + S +YIH+ ICHRD+KP N+L+D + V KL DFG ++ +V + Sbjct: 148 IPIQVIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMDKNGRV-KLSDFGESEYMVDKK 206 Query: 212 PNVSYICSRYYRAPELIFGATDYT-SSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEII 270 S + + PE + Y + +D+WS G L + + P + LVE+ Sbjct: 207 IKGSR-GTYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMFYN--VVPFSLKI-SLVELF 262 Query: 271 KVLGTPTREQIREMNPNYTEFKFPQI-KAHPWTKVFRPRTPPEAIALCSRLLEYTPTARL 329 + T E + N F +P K + F E I L P R+ Sbjct: 263 NNIRTKNIEYPLDRN----HFLYPLTNKKSTCSNNF---LSNEDIDFLKLFLRKNPAERI 315 Query: 330 TPLEACAHSFFDELRDPNVK 349 T +A H + L D N++ Sbjct: 316 TSEDALKHEW---LADTNIE 332 >3HMP-A nrPDB Length = 342 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 79/321 (24%), Positives = 132/321 (41%), Gaps = 64/321 (19%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDK-------RFKNRELQIMRKLDHCN 108 Y+ K IG+G V+Q L + ++ AIK V ++ ++N E+ + KL + Sbjct: 58 YSILKQIGSGGSSKVFQV-LNEKKQIYAIKYVNLEEADNQTLDSYRN-EIAYLNKLQQHS 115 Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRS 168 +R + Y ++ Y+ +V+ E + + K+++ K Y + + Sbjct: 116 DKIIRLYDYEITDQ----YIYMVM----ECGNIDLNSWLKKKKSIDPWERKSYWKNMLEA 167 Query: 169 LAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNV---SYICSRYYRAP 225 + IH GI H D+KP N L+ +LKL DFG A Q+ +V S + + Y P Sbjct: 168 VHTIHQHGIVHSDLKPANFLI--VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPP 225 Query: 226 ELIFGATDYTSS-------------IDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKV 272 E I D +SS DVWS GC+L + G+ F Q++ I Sbjct: 226 EAI---KDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF------QQIINQISK 276 Query: 273 LGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPL 332 L ++PN+ E +FP I P + + C L+ P R++ Sbjct: 277 LHAI-------IDPNH-EIEFPDI----------PEKDLQDVLKCC--LKRDPKQRISIP 316 Query: 333 EACAHSFFDELRDPNVKLPNG 353 E AH + P ++ G Sbjct: 317 ELLAHPYVQIQTHPVNQMAKG 337 >5O2B-A nrPDB Length = 285 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 57/199 (28%), Positives = 95/199 (47%), Gaps = 20/199 (10%) Query: 62 IGNGSFGVVYQAKLCDSGELVAIKKVLQDK--------RFKNRELQIMRKLDHCNIVRLR 113 +G G+F VY+ ++ VA + LQD+ RFK E ++++ L H NIVR Sbjct: 24 LGRGAFKTVYKGLDTETWVEVAWCE-LQDRKLTKAEQQRFKE-EAEMLKGLQHPNIVR-- 79 Query: 114 YFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIH 173 FY S E + +VL T + + R K P + ++ + Q+ + L ++H Sbjct: 80 --FYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKV-LRSWCRQILKGLQFLH 136 Query: 174 SFG--ICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGA 231 + I HRD+K N+ + T +K+ D G A L+R S I + + APE+ Sbjct: 137 TRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLA-TLMRTSFAKSVIGTPEFMAPEMY--E 193 Query: 232 TDYTSSIDVWSAGCVLAEL 250 Y S+DV++ G + E+ Sbjct: 194 EHYDESVDVYAFGMCMLEM 212 >4P5Q-A nrPDB Length = 361 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 58/205 (28%), Positives = 91/205 (44%), Gaps = 24/205 (11%) Query: 60 KVIGNGSFGVVYQA--KLCDSGEL-VAIKKVLQDKRFKNR-----ELQIMRKLDHCNIVR 111 KV+G G FG V KL E+ VAIK + K R E IM + DH NI+R Sbjct: 39 KVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIR 98 Query: 112 LRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAY 171 L S + +V +Y+ + + VI + + + + Y Sbjct: 99 LEGVVTKSKP------VMIVTEYMENG--SLDSFLRKHDAQFTVIQLVGMLRGIASGMKY 150 Query: 172 IHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSR-----YYRAPE 226 + G HRD+ +N+L++ + V K+ DFG ++ L +P +Y + +PE Sbjct: 151 LSDMGYVHRDLAARNILINSNL-VCKVSDFGLSRVL-EDDPEAAYTTRGGKIPIRWTSPE 208 Query: 227 LIFGATDYTSSIDVWSAGCVLAELL 251 I +TS+ DVWS G VL E++ Sbjct: 209 AI-AYRKFTSASDVWSYGIVLWEVM 232 >3PLS-A nrPDB Length = 298 Score = 57.0 bits (136), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 60/216 (27%), Positives = 97/216 (44%), Gaps = 33/216 (15%) Query: 54 VSYTDTKVIGNGSFGVVYQAKLCDSGE---------LVAIKKVLQDKRFKNRELQIMRKL 104 V+++D +VIG G FGVVY + D + L I ++ Q + F RE +MR L Sbjct: 22 VTHSD-RVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAFL-REGLLMRGL 79 Query: 105 DHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKL-YMY 163 +H N++ L E V L P + + R+ Q P + + + Sbjct: 80 NHPNVLALIGIMLPP-EGLPHVLL-------PYMCHGDLLQFIRSPQRNPTVKDLISFGL 131 Query: 164 QLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYR 223 Q+ R + Y+ HRD+ +N +LD ++ +K+ DFG A+ ++ E Y + +R Sbjct: 132 QVARGMEYLAEQKFVHRDLAARNCMLD-ESFTVKVADFGLARDILDRE----YYSVQQHR 186 Query: 224 APELIFGAT--------DYTSSIDVWSAGCVLAELL 251 L T +T+ DVWS G +L ELL Sbjct: 187 HARLPVKWTALESLQTYRFTTKSDVWSFGVLLWELL 222 >5GNK-A nrPDB Length = 297 Score = 57.0 bits (136), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 58/228 (25%), Positives = 100/228 (43%), Gaps = 30/228 (13%) Query: 42 ATPGQGPDRP-----QEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKR---- 92 A G+ P++ +E + KV+G+G+FG VY+ GE V I +++ R Sbjct: 2 AMGGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATS 61 Query: 93 -FKNREL----QIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYS 147 N+E+ +M +D+ ++ RL +S + L++ +P + Y Sbjct: 62 PKANKEILDEAYVMASVDNPHVCRLLGICLTST-------VQLIMQLMP---FGCLLDYV 111 Query: 148 RA-KQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ 206 R K + Y+ + Q+ + + Y+ + HRD+ +N+L+ V K+ DFG AK Sbjct: 112 REHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHV-KITDFGLAKL 170 Query: 207 LVRGEPNVSYICSRY---YRAPELIFGATDYTSSIDVWSAGCVLAELL 251 L E + + A E I YT DVWS G + EL+ Sbjct: 171 LGAEEKEYHAEGGKVPIKWMALESILHRI-YTHQSDVWSYGVTVWELM 217 >3QGY-A nrPDB Length = 286 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 68/284 (23%), Positives = 122/284 (42%), Gaps = 31/284 (10%) Query: 51 PQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN---RELQIMRKLDHC 107 P E+++ IG+G FG+V+ + + VAIK + + ++ E ++M KL H Sbjct: 26 PSELTFVQE--IGSGQFGLVHLGYWLNKDK-VAIKTIKEGSMSEDDFIEEAEVMMKLSHP 82 Query: 108 NIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYM-YQLF 166 +V+L G ++ + LV +++ + Y R ++ L L M + Sbjct: 83 KLVQLY------GVCLEQAPICLVFEFME---HGCLSDYLRTQRGLFAAETLLGMCLDVC 133 Query: 167 RSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY---YR 223 +AY+ + HRD+ +N L+ + V+K+ DFG + V + S +++ + Sbjct: 134 EGMAYLEEACVIHRDLAARNCLVG-ENQVIKVSDFGMTR-FVLDDQYTSSTGTKFPVKWA 191 Query: 224 APELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIRE 283 +PE +F + Y+S DVWS G ++ E+ I + ++VE I R Sbjct: 192 SPE-VFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDIST-------GFRL 243 Query: 284 MNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTA 327 P QI H W + RP P L +L E + Sbjct: 244 YKPRLASTHVYQIMNHCWKE--RPEDRPAFSRLLRQLAEIAESG 285 >5GRN-A nrPDB Length = 356 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 36/103 (34%), Positives = 56/103 (54%), Gaps = 6/103 (5%) Query: 161 YMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSR 220 + YQ+ R + ++ S HRD+ +N+LL ++K+CDFG A+ ++ VS + Sbjct: 181 FTYQVARGMEFLASKNCVHRDLAARNVLL-AQGKIVKICDFGLARDIMHDSNYVSKGSTF 239 Query: 221 Y---YRAPELIFGATDYTSSIDVWSAGCVLAELL-LGQPIFPG 259 + APE IF YT+ DVWS G +L E+ LG +PG Sbjct: 240 LPVKWMAPESIFDNL-YTTLSDVWSYGILLWEIFSLGGTPYPG 281 >5U6B-A nrPDB Length = 307 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 54/223 (24%), Positives = 95/223 (42%), Gaps = 33/223 (14%) Query: 60 KVIGNGSFGVVYQAKLCDSGELVAIK-KVLQDKRFKNRELQ-------IMRKLDHCNIVR 111 K +G G FG V + +L ++ + K ++ EL+ M++ DH N++R Sbjct: 29 KTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMR 88 Query: 112 LRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQT---LPVIYVKLYMYQLFRS 168 L + E++ ++L ++ YSR LP + +M + Sbjct: 89 LIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASG 148 Query: 169 LAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPEL- 227 + Y+ + HRD+ +N +L+ + +V + DFG +K++ G+ YYR + Sbjct: 149 MEYLSTKRFIHRDLAARNCMLNENMSVC-VADFGLSKKIYNGD---------YYRQGRIA 198 Query: 228 --------IFGATD--YTSSIDVWSAGCVLAELLL-GQPIFPG 259 I D YTS DVWS G + E+ GQ +PG Sbjct: 199 KMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPG 241 >2R2P-A nrPDB Length = 295 Score = 55.8 bits (133), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 59/208 (28%), Positives = 92/208 (44%), Gaps = 24/208 (11%) Query: 57 TDTKVIGNGSFGVVYQAKLCDSG--EL-VAIKKVLQDKRFKNR-----ELQIMRKLDHCN 108 T +VIG G FG V +L G EL VAIK + K R E IM + DH N Sbjct: 25 TIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPN 84 Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRS 168 I+ L S + +V +Y+ + + VI + + + Sbjct: 85 IIHLEGVVTKSKP------VMIVTEYMENG--SLDTFLKKNDGQFTVIQLVGMLRGISAG 136 Query: 169 LAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSR-----YYR 223 + Y+ G HRD+ +N+L++ + V K+ DFG ++ L +P +Y + Sbjct: 137 MKYLSDMGYVHRDLAARNILINSNL-VCKVSDFGLSRVL-EDDPEAAYTTRGGKIPIRWT 194 Query: 224 APELIFGATDYTSSIDVWSAGCVLAELL 251 APE I +TS+ DVWS G V+ E++ Sbjct: 195 APEAI-AFRKFTSASDVWSYGIVMWEVV 221 >5AP3-A nrPDB Length = 313 Score = 55.5 bits (132), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 77/321 (23%), Positives = 134/321 (41%), Gaps = 64/321 (19%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDK-------RFKNRELQIMRKLDHCN 108 Y+ K IG+G V+Q L + ++ AIK V ++ ++N E+ + KL + Sbjct: 30 YSILKQIGSGGSSKVFQV-LNEKKQIYAIKYVNLEEADNQTLDSYRN-EIAYLNKLQQHS 87 Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRS 168 +R + Y ++ Y+ +V+ E + + K+++ K Y + + Sbjct: 88 DKIIRLYDYEITDQ----YIYMVM----ECGNIDLNGWLKKKKSIDPWERKSYWKNMLEA 139 Query: 169 LAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNV---SYICSRYYRAP 225 + IH GI H D+KP N L+ +LKL DFG A Q+ +V S + + Y P Sbjct: 140 VHTIHQHGIVHSDLKPANFLI--VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPP 197 Query: 226 ELIFGATDYTSS-------------IDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKV 272 E I D +SS DVWS GC+L + G+ P ++Q+ ++ + Sbjct: 198 EAI---KDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKT--PFQQIINQISKLHAI 252 Query: 273 LGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPL 332 + +PN+ E +FP I P + + C L+ P R++ Sbjct: 253 I-----------DPNH-EIEFPDI----------PEKDLQDVLKCC--LKRDPKQRISIP 288 Query: 333 EACAHSFFDELRDPNVKLPNG 353 E AH + P ++ G Sbjct: 289 ELLAHPYVQIQTHPVNQMAKG 309 >3LZB-A nrPDB Length = 327 Score = 55.5 bits (132), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 58/226 (25%), Positives = 98/226 (43%), Gaps = 32/226 (14%) Query: 45 GQGPDRP-----QEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKR-----FK 94 G+ P++ +E + KV+G+G+FG VY+ GE V I +++ R Sbjct: 1 GEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKA 60 Query: 95 NREL----QIMRKLDHCNIVRLRYFFYSSGEK--KDEVYLNLVLDYVPETVYRVARHYSR 148 N+E+ +M +D+ ++ RL +S + + +LDYV E Sbjct: 61 NKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVRE----------- 109 Query: 149 AKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLV 208 K + Y+ + Q+ + + Y+ + HRD+ +N+L+ V K+ DFG AK L Sbjct: 110 HKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHV-KITDFGLAKLLG 168 Query: 209 RGEPNVSYICSRY---YRAPELIFGATDYTSSIDVWSAGCVLAELL 251 E + + A E I YT DVWS G + EL+ Sbjct: 169 AEEKEYHAEGGKVPIKWMALESILHRI-YTHQSDVWSYGVTVWELM 213 >3BBT-B nrPDB Length = 328 Score = 55.1 bits (131), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 58/225 (25%), Positives = 94/225 (41%), Gaps = 30/225 (13%) Query: 45 GQGPDRPQ-----EVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIK---KVLQDK----- 91 G P++ Q E KV+G+G+FG VY+ GE V I K+L + Sbjct: 1 GTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKA 60 Query: 92 --RFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRA 149 F + L IM +DH ++VRL S + LV +P + + Sbjct: 61 NVEFMDEAL-IMASMDHPHLVRLLGVCLSPT-------IQLVTQLMPHGC--LLEYVHEH 110 Query: 150 KQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVR 209 K + + + Q+ + + Y+ + HRD+ +N+L+ V K+ DFG A+ L Sbjct: 111 KDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHV-KITDFGLARLLEG 169 Query: 210 GEPNVSYICSRY---YRAPELIFGATDYTSSIDVWSAGCVLAELL 251 E + + + A E I +T DVWS G + EL+ Sbjct: 170 DEKEYNADGGKMPIKWMALECIH-YRKFTHQSDVWSYGVTIWELM 213 >1FVR-A nrPDB Length = 327 Score = 55.1 bits (131), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 63/223 (28%), Positives = 100/223 (44%), Gaps = 34/223 (15%) Query: 54 VSYTDTK---VIGNGSFGVVYQAKLCDSGELV--AIKKVLQ-----DKRFKNRELQIMRK 103 + + D K VIG G+FG V +A++ G + AIK++ + D R EL+++ K Sbjct: 22 LDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCK 81 Query: 104 LDHC-NIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVK--- 159 L H NI+ L G + YL L ++Y P SR +T P + Sbjct: 82 LGHHPNIINLL------GACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANST 135 Query: 160 ---LYMYQLF-------RSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFG-SAKQLV 208 L QL R + Y+ HRD+ +N+L+ + V K+ DFG S Q V Sbjct: 136 ASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILV-GENYVAKIADFGLSRGQEV 194 Query: 209 RGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELL 251 + + + R+ L + YT++ DVWS G +L E++ Sbjct: 195 YVKKTMGRLPVRWMAIESLNYSV--YTTNSDVWSYGVLLWEIV 235 >3KUL-B nrPDB Length = 325 Score = 55.1 bits (131), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 56/205 (27%), Positives = 93/205 (45%), Gaps = 24/205 (11%) Query: 60 KVIGNGSFGVVYQAKLCDSGEL---VAIKKVLQDKRFKNR-----ELQIMRKLDHCNIVR 111 K+IG+G G V +L G+ VAIK + + R E IM + DH NI+R Sbjct: 55 KIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGYTERQRRDFLSEASIMGQFDHPNIIR 114 Query: 112 LRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAY 171 L G +V +Y+ + T ++ + + + + Y Sbjct: 115 L------EGVVTRGRLAMIVTEYMENGSLDTFLRTHDGQFT--IMQLVGMLRGVGAGMRY 166 Query: 172 IHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSR-----YYRAPE 226 + G HRD+ +N+L+D + V K+ DFG ++ L +P+ +Y + + APE Sbjct: 167 LSDLGYVHRDLAARNVLVDSNL-VCKVSDFGLSRVL-EDDPDAAYTTTGGKIPIRWTAPE 224 Query: 227 LIFGATDYTSSIDVWSAGCVLAELL 251 I T ++S+ DVWS G V+ E+L Sbjct: 225 AIAFRT-FSSASDVWSFGVVMWEVL 248 >4XCU-A nrPDB Length = 300 Score = 54.7 bits (130), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 65/242 (26%), Positives = 109/242 (45%), Gaps = 48/242 (19%) Query: 60 KVIGNGSFGVVYQAKLC-------DSGELVAIKKVLQDKRFKN-----RELQIMRKLD-H 106 K +G G FG V +A+ D VA+K + + K+ E+++M+ + H Sbjct: 23 KPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRH 82 Query: 107 CNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQ---------TLPVIY 157 NI+ L G E L ++++ + R + RA++ + PV+ Sbjct: 83 KNIINL------LGVCTQEGPLYVIVECAAKGNLR---EFLRARRPPGSSEGPLSFPVLV 133 Query: 158 VKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYI 217 YQ+ R + Y+ S HRD+ +N+L+ D V+K+ DFG L RG ++ Y Sbjct: 134 S--CAYQVARGMQYLESRKCIHRDLAARNVLVTEDN-VMKIADFG----LARGVHHIDYY 186 Query: 218 -------CSRYYRAPELIFGATDYTSSIDVWSAGCVLAELL-LGQPIFPGDSGVDQLVEI 269 + APE +F YT DVWS G +L E+ LG +PG V++L + Sbjct: 187 KKTSNGRLPVKWMAPEALFDRV-YTHQSDVWSFGILLWEIFTLGGSPYPGIP-VEELFSL 244 Query: 270 IK 271 ++ Sbjct: 245 LR 246 >4JRN-A nrPDB Length = 372 Score = 54.7 bits (130), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 67/276 (24%), Positives = 107/276 (38%), Gaps = 54/276 (19%) Query: 36 KVTTVVATPGQGPDRPQEVSYTDTKVI------GNGSFGVVYQAKLCDSGELVAIKKVLQ 89 ++ TV A P P R V+ +T+ + G+G F VY+A ++ E +A+K + Sbjct: 44 RILTVAAWPPDVPKRFVSVTTGETRTLVRGAPLGSGGFATVYEATDVETNEELAVKVFMS 103 Query: 90 DKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEK----------------------KDEVY 127 +K + + +++ C R F + K EV Sbjct: 104 EKEPTDETMLDLQRESSC----YRNFSLAKTAKDAQESCRFMVPSDVVMLEGQPASTEVV 159 Query: 128 LNLVLDYVPETVYRVARHYSRAKQTLPVIY-------------VKLYMY-QLFRSLAYIH 173 + L +VP + R + + + ++ V++Y+ Q + +A + Sbjct: 160 IGLTTRWVPNYFLLMMRAEADMSKVISWVFGDASVNKSEFGLVVRMYLSSQAIKLVANVQ 219 Query: 174 SFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVS-YICSRYYRAPELIFGAT 232 + GI H DIKP N LL D L L DFG+ R +V I + Y PE F AT Sbjct: 220 AQGIVHTDIKPANFLLLKD-GRLFLGDFGT----YRINNSVGRAIGTPGYEPPERPFQAT 274 Query: 233 D--YTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQL 266 YT D W G L + + P D D L Sbjct: 275 GITYTFPTDAWQLGITLYCIWCKERPTPADGIWDYL 310 >3TT0-A nrPDB Length = 382 Score = 54.7 bits (130), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 38/113 (33%), Positives = 60/113 (53%), Gaps = 7/113 (6%) Query: 163 YQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY- 221 YQ+ R + Y+ S HRD+ +N+L+ D V+K+ DFG A+ + + R Sbjct: 198 YQVARGMEYLASKKCIHRDLAARNVLVTEDN-VMKIADFGLARDIHHIDYYKKTTNGRLP 256 Query: 222 --YRAPELIFGATDYTSSIDVWSAGCVLAELL-LGQPIFPGDSGVDQLVEIIK 271 + APE +F YT DVWS G +L E+ LG +PG V++L +++K Sbjct: 257 VKWMAPEALFDRI-YTHQSDVWSFGVLLWEIFTLGGSPYPG-VPVEELFKLLK 307 >4K33-A nrPDB Length = 325 Score = 54.7 bits (130), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 40/117 (34%), Positives = 60/117 (51%), Gaps = 15/117 (12%) Query: 163 YQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSR-- 220 YQ+ R + Y+ S HRD+ +N+L+ D V+K+ DFG L R N+ Y Sbjct: 165 YQVARGMEYLASQKCIHRDLAARNVLVTEDN-VMKIADFG----LARDVHNLDYYKETTN 219 Query: 221 -----YYRAPELIFGATDYTSSIDVWSAGCVLAELL-LGQPIFPGDSGVDQLVEIIK 271 + APE +F YT DVWS G +L E+ LG +PG V++L +++K Sbjct: 220 GRLPVKWMAPEALFDRV-YTHQSDVWSFGVLLWEIFTLGGSPYPGIP-VEELFKLLK 274 >3GQL-A nrPDB Length = 326 Score = 54.3 bits (129), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 38/113 (33%), Positives = 60/113 (53%), Gaps = 7/113 (6%) Query: 163 YQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY- 221 YQ+ R + Y+ S HRD+ +N+L+ D V+K+ DFG A+ + + R Sbjct: 157 YQVARGMEYLASKKCIHRDLAARNVLVTEDN-VMKIADFGLARDIHHIDYYKKTTNGRLP 215 Query: 222 --YRAPELIFGATDYTSSIDVWSAGCVLAELL-LGQPIFPGDSGVDQLVEIIK 271 + APE +F YT DVWS G +L E+ LG +PG V++L +++K Sbjct: 216 VKWMAPEALFDRI-YTHQSDVWSFGVLLWEIFTLGGSPYPG-VPVEELFKLLK 266 >2X7G-A nrPDB Length = 389 Score = 54.3 bits (129), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 70/290 (24%), Positives = 118/290 (40%), Gaps = 75/290 (25%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN------RELQIMRKLDHCN- 108 Y + +G G F V+ VA+K V + + + L+ +R+ D + Sbjct: 33 YHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDP 92 Query: 109 ----IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYR--VARHYSRAKQTLPVIYVKLYM 162 +V+L F SG + +++ +V + + + + + +Y Q LPV VK + Sbjct: 93 NKDMVVQLIDDFKISG--MNGIHVCMVFEVLGHHLLKWIIKSNY----QGLPVRCVKSII 146 Query: 163 YQLFRSLAYIHS-FGICHRDIKPQNLL--------------------------------- 188 Q+ + L Y+HS I H DIKP+N+L Sbjct: 147 RQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAVST 206 Query: 189 ----------LDP---DTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYT 235 LDP D +K+ D G+A + + I +R YR+ E++ GA Y+ Sbjct: 207 APAADLLVNPLDPRNADKIRVKIADLGNACWVHK--HFTEDIQTRQYRSIEVLIGAG-YS 263 Query: 236 SSIDVWSAGCVLAELLLGQPIFPGDSG------VDQLVEIIKVLGTPTRE 279 + D+WS C+ EL G +F SG D + II++LG+ R Sbjct: 264 TPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRH 313 >2QLU-A nrPDB Length = 314 Score = 54.3 bits (129), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 60/216 (27%), Positives = 102/216 (47%), Gaps = 36/216 (16%) Query: 60 KVIGNGSFGVVYQAKLCDSGELVAIKKV-LQDKRFKNRELQIMRK--LDHCNIVRLRYFF 116 ++ G FG V++A+L + + VA+K LQDK+ E +I + H N+++ Sbjct: 21 EIKARGRFGCVWKAQLMN--DFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQ----- 73 Query: 117 YSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKL--YMYQLFRSLAYIHS 174 + + EK+ NL ++ T + + + + + +L + R L+Y+H Sbjct: 74 FIAAEKRGS---NLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHE 130 Query: 175 F-----------GICHRDIKPQNLLLDPD-TAVLKLCDFGSAKQLVRGEP---NVSYICS 219 I HRD K +N+LL D TAV L DFG A + G+P + + Sbjct: 131 DVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAV--LADFGLAVRFEPGKPPGDTHGQVGT 188 Query: 220 RYYRAPELIFGATDYTSS----IDVWSAGCVLAELL 251 R Y APE++ GA ++ ID+++ G VL EL+ Sbjct: 189 RRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELV 224 >2PSQ-A nrPDB Length = 370 Score = 54.3 bits (129), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 38/117 (32%), Positives = 61/117 (52%), Gaps = 15/117 (12%) Query: 163 YQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSR-- 220 YQL R + Y+ S HRD+ +N+L+ + V+K+ DFG A+ + N+ Y Sbjct: 210 YQLARGMEYLASQKCIHRDLAARNVLV-TENNVMKIADFGLARDI----NNIDYYKKTTN 264 Query: 221 -----YYRAPELIFGATDYTSSIDVWSAGCVLAELL-LGQPIFPGDSGVDQLVEIIK 271 + APE +F YT DVWS G ++ E+ LG +PG V++L +++K Sbjct: 265 GRLPVKWMAPEALFDRV-YTHQSDVWSFGVLMWEIFTLGGSPYPG-IPVEELFKLLK 319 >5A46-A nrPDB Length = 386 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 38/113 (33%), Positives = 60/113 (53%), Gaps = 7/113 (6%) Query: 163 YQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY- 221 YQ+ R + Y+ S HRD+ +N+L+ D V+K+ DFG A+ + + R Sbjct: 169 YQVARGMEYLASKKCIHRDLAARNVLVTEDN-VMKIADFGLARDIHHIDYYKKTTNGRLP 227 Query: 222 --YRAPELIFGATDYTSSIDVWSAGCVLAELL-LGQPIFPGDSGVDQLVEIIK 271 + APE +F YT DVWS G +L E+ LG +PG V++L +++K Sbjct: 228 VKWMAPEALFDRI-YTHQSDVWSFGVLLWEIFTLGGSPYPG-VPVEELFKLLK 278 >5O0Y-A nrPDB Length = 579 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 72/289 (24%), Positives = 115/289 (39%), Gaps = 57/289 (19%) Query: 67 FGVVYQAKLCDSGELVAIK-----KVLQDKRFKN------RELQIMRKLDHCNIVRLRYF 115 F VY+A VA+K K +D++ +N RE +I ++LDH IV+L Y Sbjct: 297 FSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKL-YD 355 Query: 116 FYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSF 175 ++S D VL+Y Y + + + + + Q+ +L Y++ Sbjct: 356 YFSL----DTDSFCTVLEYCEGNDLDF---YLKQHKLMSEKEARSIIMQIVNALKYLNEI 408 Query: 176 G--ICHRDIKPQNLLLDPDTAV--LKLCDFGSAKQL-------VRGEPNVSYICSRYYRA 224 I H D+KP N+LL TA +K+ DFG +K + V G S Y+ Sbjct: 409 KPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYL 468 Query: 225 PELIFGATD----YTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQ 280 P F ++ +DVWS G + + L G+ F + +++ +L Sbjct: 469 PPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKA----- 523 Query: 281 IREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARL 329 TE +FP +P PEA A R L Y R+ Sbjct: 524 --------TEVQFPP----------KPVVTPEAKAFIRRCLAYRKEDRI 554 >4NEU-A nrPDB Length = 333 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 51/205 (24%), Positives = 86/205 (41%), Gaps = 23/205 (11%) Query: 96 RELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPV 155 E ++M +L H +V+L G+ +LV++Y+ + H +A+ + P+ Sbjct: 71 EEAKMMNRLRHSRVVKLLGVIIEEGK------YSLVMEYMEKGNLM---HVLKAEMSTPL 121 Query: 156 IYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPD----TAVLKLCDFGSAKQLVRGE 211 + ++ + Y+H G+ H+D+KP+N+L+D D A L L F +L E Sbjct: 122 SVKGRIILEIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEE 181 Query: 212 PN----VSYICSR-----YYRAPELIFGATDY-TSSIDVWSAGCVLAELLLGQPIFPGDS 261 N V + YY APE + T DV+S VL + + + Sbjct: 182 HNELREVDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAI 241 Query: 262 GVDQLVEIIKVLGTPTREQIREMNP 286 QL+ IK P + I E P Sbjct: 242 CEQQLIMCIKSGNRPDVDDITEYCP 266 >5J0A-A nrPDB Length = 300 Score = 53.5 bits (127), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 45/197 (22%), Positives = 80/197 (40%), Gaps = 31/197 (15%) Query: 62 IGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGE 121 I N + VYQ +L D E +I++ L H NIV R F Sbjct: 48 ICNDHYRSVYQKRLMD-------------------EAKILKSLHHPNIVGYRAF-----T 83 Query: 122 KKDEVYLNLVLDYVPETVYR--VARHYSRAKQTLPVIYVKLYMYQLFRSLAYIH-SFGIC 178 + ++ L L ++Y E + Y ++ P + + R L Y+H + Sbjct: 84 EANDGSLCLAMEYGGEKSLNDLIEERYKASQDPFPAAIILKVALNMARGLKYLHQEKKLL 143 Query: 179 HRDIKPQNLLLDPDTAVLKLCDFGSA----KQLVRGEPNVSYICSRYYRAPELIFGATDY 234 H DIK N+++ D +K+CD G + + + +P YI + ++ E + Sbjct: 144 HGDIKSSNVVIKGDFETIKICDVGVSLPLDENMEVTDPEACYIGTEPWKPKEAVEENGVI 203 Query: 235 TSSIDVWSAGCVLAELL 251 T D+++ G L E++ Sbjct: 204 TDKADIFAFGLTLWEMM 220 >5EG3-A nrPDB Length = 334 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 37/117 (31%), Positives = 61/117 (52%), Gaps = 15/117 (12%) Query: 163 YQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSR-- 220 YQL R + Y+ S HRD+ +N+L+ + V+K+ DFG A+ + N+ + Sbjct: 164 YQLARGMEYLASQKCIHRDLAARNVLV-TENNVMKIADFGLARDI----NNIDFFKETTN 218 Query: 221 -----YYRAPELIFGATDYTSSIDVWSAGCVLAELL-LGQPIFPGDSGVDQLVEIIK 271 + APE +F YT DVWS G ++ E+ LG +PG V++L +++K Sbjct: 219 GRLPVKWMAPEALFDRV-YTHQSDVWSFGVLMWEIFTLGGSPYPG-IPVEELFKLLK 273 >5M07-A nrPDB Length = 276 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 55/211 (26%), Positives = 89/211 (42%), Gaps = 31/211 (14%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIK----KVLQDKRFK---NRELQIMRKLDHC 107 YT +++G + G VY + A+K + D F+ RE ++ +L H Sbjct: 31 GYTVVRMLGASAMGEVYLVQHPGFPGWQALKVLSPAMAADDEFRRRFQRETEVAARLFHP 90 Query: 108 NIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFR 167 +I+ + + GE ++++ +DYV + + R LPV V + + Sbjct: 91 HILEV----HDRGEFDGQLWI--AMDYV-DGIDATQHMADRFPAVLPVGEVLAIVTAVAG 143 Query: 168 SLAYIHSFGICHRDIKPQNLLLDPDTAV---LKLCDFGSAKQLVRGEPNVSYICSRYYRA 224 +L Y H G+ HRD+ P N++L +A + L DFG A Q P+ Y A Sbjct: 144 ALDYAHQRGLLHRDVNPANVVLTSQSAGDQRILLADFGIASQ-----PS--------YPA 190 Query: 225 PELIFGATDYTSSIDVWSAGCVLAELLLGQP 255 PEL GA D D ++ L G P Sbjct: 191 PELSAGA-DVDGRADQYALALTAIHLFAGAP 220 >4OTD-A nrPDB Length = 341 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 68/274 (24%), Positives = 113/274 (41%), Gaps = 40/274 (14%) Query: 61 VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIM----RKLDHCNIVRLRYFF 116 V+G G FG V ++ SGEL AIK + + E++ + R L + Sbjct: 19 VLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTSAGHPFLV 78 Query: 117 YSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFG 176 G + ++ V++Y + H + + Y + L ++H Sbjct: 79 NLFGCFQTPEHVCFVMEYSAGGDLMLHIHSDVFSEPRAIFYSACVVL----GLQFLHEHK 134 Query: 177 ICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ-LVRGEPNVSYICSRYYRAPELIFGATDYT 235 I +RD+K NLLLD + V K+ DFG K+ + G+ ++ + + APE + T YT Sbjct: 135 IVYRDLKLDNLLLDTEGYV-KIADFGLCKEGMGYGDRTSTFCGTPEFLAPE-VLTDTSYT 192 Query: 236 SSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQ 295 ++D W G +L E+L+G+ FPGD + I+ E ++P+ Sbjct: 193 RAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVN-----------------DEVRYPR 235 Query: 296 IKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARL 329 + EAI + RLL P RL Sbjct: 236 FLS------------AEAIGIMRRLLRRNPERRL 257 >4YFF-A nrPDB Length = 311 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 60/249 (24%), Positives = 105/249 (42%), Gaps = 23/249 (9%) Query: 17 VQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLC 76 V PS G +K + + P + E+ + + +IG+GSFG VY+ + Sbjct: 7 VSVPSPLGKIKSMTKEKADILLLRAGLPSHFHLQLSEIEFHE--IIGSGSFGKVYKGRC- 63 Query: 77 DSGELVAIKKVL-------QDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLN 129 ++VAIK+ D RE+ I+ +L+H +++ + D Sbjct: 64 -RNKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVIQ-----FVGACLNDPSQFA 117 Query: 130 LVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFG--ICHRDIKPQNL 187 +V Y+ H K+ L + + + + + Y+H+ I HRD+ N+ Sbjct: 118 IVTQYISGGSLFSLLH--EQKRILDLQSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNI 175 Query: 188 LLDPDTAVLKLCDFGSAKQLVR-GEPNVSYICSRY-YRAPELIFGATDYTSSIDVWSAGC 245 LL D + + DFG ++ L E N++ + APE+ T YT DV+S Sbjct: 176 LLYEDGHAV-VADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTRYTIKADVFSYAL 234 Query: 246 VLAELLLGQ 254 L E+L G+ Sbjct: 235 CLWEILTGE 243 >3BEA-A nrPDB Length = 333 Score = 52.8 bits (125), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 63/226 (27%), Positives = 97/226 (42%), Gaps = 34/226 (15%) Query: 60 KVIGNGSFGVVYQAKLCDSGELVAIKKVL----------QDKRFKNRELQIMRKL-DHCN 108 K +G G+FG V +A G+ A+ KV +K EL+IM L H N Sbjct: 52 KTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHEN 111 Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVP-ETVYRVARHYSRAKQTLPVIYVK-------- 159 IV L G + ++ +Y + R SR +T P + Sbjct: 112 IVNLLGACTHGGP------VLVITEYCCYGDLLNFLRRKSRVLETDPAFAIANSTLSTRD 165 Query: 160 --LYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYI 217 + Q+ + +A++ S HRD+ +N+LL + V K+ DFG A+ ++ + Sbjct: 166 LLHFSSQVAQGMAFLASKNCIHRDVAARNVLL-TNGHVAKIGDFGLARDIMNDSNYIVKG 224 Query: 218 CSRY---YRAPELIFGATDYTSSIDVWSAGCVLAELL-LGQPIFPG 259 +R + APE IF YT DVWS G +L E+ LG +PG Sbjct: 225 NARLPVKWMAPESIFDCV-YTVQSDVWSYGILLWEIFSLGLNPYPG 269 >3DKO-A nrPDB Length = 318 Score = 52.8 bits (125), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 54/205 (26%), Positives = 94/205 (45%), Gaps = 24/205 (11%) Query: 60 KVIGNGSFGVVYQAKLCDSGE---LVAIKKVLQDKRFKNR-----ELQIMRKLDHCNIVR 111 +VIG G FG V +L G+ VAIK + K R E IM + DH N+V Sbjct: 49 RVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNVVH 108 Query: 112 LRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAY 171 L + G+ + +V++++ + + VI + + + + Y Sbjct: 109 LEGVV-TRGKP-----VMIVIEFMENGA--LDAFLRKHDGQFTVIQLVGMLRGIAAGMRY 160 Query: 172 IHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSR-----YYRAPE 226 + G HRD+ +N+L++ + V K+ DFG ++ ++ +P Y + + APE Sbjct: 161 LADMGYVHRDLAARNILVNSNL-VCKVSDFGLSR-VIEDDPEAVYTTTGGKIPVRWTAPE 218 Query: 227 LIFGATDYTSSIDVWSAGCVLAELL 251 I +TS+ DVWS G V+ E++ Sbjct: 219 AI-QYRKFTSASDVWSYGIVMWEVM 242 >4E93-A nrPDB Length = 377 Score = 52.8 bits (125), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 65/218 (29%), Positives = 99/218 (45%), Gaps = 37/218 (16%) Query: 62 IGNGSFGVVYQAKLCDSGELVAIKKVLQ----DKRFKN-RELQIMRKLDHCNIVRLRYFF 116 IG G+FG V+ +L LVA+K + D + K +E +I+++ H NIVRL Sbjct: 122 IGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHPNIVRL---- 177 Query: 117 YSSGEKKDEVYLNLVL----DYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYI 172 +K +Y+ + L D++ T R R K L ++ + Y+ Sbjct: 178 IGVCTQKQPIYIVMELVQGGDFL--TFLRTEGARLRVKTLLQMV------GDAAAGMEYL 229 Query: 173 HSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYR-------AP 225 S HRD+ +N L+ + VLK+ DFG +++ E + Y S R AP Sbjct: 230 ESKCCIHRDLAARNCLVT-EKNVLKISDFGMSRE----EADGVYAASGGLRQVPVKWTAP 284 Query: 226 E-LIFGATDYTSSIDVWSAGCVLAELL-LGQPIFPGDS 261 E L +G Y+S DVWS G +L E LG +P S Sbjct: 285 EALNYGR--YSSESDVWSFGILLWETFSLGASPYPNLS 320 >3A4O-X nrPDB Length = 286 Score = 52.8 bits (125), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 56/221 (25%), Positives = 109/221 (49%), Gaps = 24/221 (10%) Query: 59 TKVIGNGSFGVVYQAKLCDSGELVAIKKV----LQDKRFKNRELQIMRKLDHCNIVRLRY 114 K +G G FG V+ +S + VA+K + + + F E +M+ L H +VRL Sbjct: 18 VKRLGAGQFGEVWMGYYNNSTK-VAVKTLKPGTMSVQAFLE-EANLMKTLQHDKLVRL-- 73 Query: 115 FFYSSGEKKDEVYLNLVLDYVPE-TVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIH 173 Y+ +++ +Y+ + +Y+ + ++ + K LP + + Q+ +AYI Sbjct: 74 --YAVVTREEPIYI--ITEYMAKGSLLDFLKSDEGGKVLLPKLID--FSAQIAEGMAYIE 127 Query: 174 SFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY---YRAPELI-F 229 HRD++ N+L+ ++ + K+ DFG A+ ++ + +++ + APE I F Sbjct: 128 RKNYIHRDLRAANVLVS-ESLMCKIADFGLAR-VIEDNEYTAREGAKFPIKWTAPEAINF 185 Query: 230 GATDYTSSIDVWSAGCVLAELL-LGQPIFPGDSGVDQLVEI 269 G +T DVWS G +L E++ G+ +PG + D + + Sbjct: 186 GC--FTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTAL 224 >4XEY-B nrPDB Length = 408 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 58/225 (25%), Positives = 109/225 (48%), Gaps = 34/225 (15%) Query: 62 IGNGSFGVVYQAKLCDSGELVAIKKVLQD----KRFKNRELQIMRKLDHCNIVRLRYF-- 115 +G G +G VY+ VA+K + +D + F +E +M+++ H N+V+L Sbjct: 133 LGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFL-KEAAVMKEIKHPNLVQLLGVCT 191 Query: 116 ----FYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYM-YQLFRSLA 170 FY E Y NL LDY+ E +Q + + V LYM Q+ ++ Sbjct: 192 REPPFYIITEFM--TYGNL-LDYLREC----------NRQEVNAV-VLLYMATQISSAME 237 Query: 171 YIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY---YRAPEL 227 Y+ HRD+ +N L+ + ++K+ DFG ++ L+ G+ ++ +++ + APE Sbjct: 238 YLEKKNFIHRDLAARNCLVG-ENHLVKVADFGLSR-LMTGDTYTAHAGAKFPIKWTAPES 295 Query: 228 IFGATDYTSSIDVWSAGCVLAEL-LLGQPIFPGDSGVDQLVEIIK 271 + ++ DVW+ G +L E+ G +PG + Q+ E+++ Sbjct: 296 L-AYNKFSIKSDVWAFGVLLWEIATYGMSPYPGID-LSQVYELLE 338 >5L6P-A nrPDB Length = 298 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 54/206 (26%), Positives = 90/206 (43%), Gaps = 24/206 (11%) Query: 60 KVIGNGSFGVVYQAKLCDSGE---LVAIKKVLQDKRFKNR-----ELQIMRKLDHCNIVR 111 +VIG G FG V + +L G VAIK + + R E IM + DH NI+R Sbjct: 25 EVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQRRDFLSEASIMGQFDHPNIIR 84 Query: 112 LRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAY 171 L S + + + + ++ R+ VI + + + + Y Sbjct: 85 LEGVVTKS--RPVMILTEFMENCALDSFLRLN------DGQFTVIQLVGMLRGIAAGMKY 136 Query: 172 IHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSR------YYRAP 225 + HRD+ +N+L++ + V K+ DFG ++ L + +Y S + AP Sbjct: 137 LSEMNYVHRDLAARNILVNSNL-VCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTAP 195 Query: 226 ELIFGATDYTSSIDVWSAGCVLAELL 251 E I +TS+ DVWS G V+ E++ Sbjct: 196 EAI-AYRKFTSASDVWSYGIVMWEVM 220 >5XD6-A nrPDB Length = 305 Score = 52.4 bits (124), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 64/216 (29%), Positives = 98/216 (45%), Gaps = 26/216 (12%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNR---ELQIMRKLDHCNIVR 111 +Y +IG GS+G V+ + SG+ AIKK+ K+ ++ ++ +L N+V Sbjct: 23 NYGSKSLIGEGSYGRVFYG-ILKSGKAAAIKKLDSSKQPDQEFLAQVSMVSRLRQENVVA 81 Query: 112 LRYFFYSSGEKKDEVYLNLVLDYVPE-TVYRV--ARHYSRAKQTLPVIY----VKLYMYQ 164 L G D L +Y P +++ + R + Q PV+ VK+ + Sbjct: 82 LL------GYCVDGPLRVLAYEYAPNGSLHDILHGRKGVKGAQPGPVLSWHQRVKIAV-G 134 Query: 165 LFRSLAYIHSFG---ICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ---LVRGEPNVSYIC 218 R L Y+H + HRDIK N+LL D V K+ DF + Q + + + Sbjct: 135 AARGLEYLHEKANPHVIHRDIKSSNVLLFDDD-VAKIADFDLSNQAPDMAARLHSTRVLG 193 Query: 219 SRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQ 254 + Y APE T T S DV+S G VL ELL G+ Sbjct: 194 TFGYHAPEYAMTGTLSTKS-DVYSFGVVLLELLTGR 228 >4BTK-A nrPDB Length = 337 Score = 52.4 bits (124), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 59/210 (28%), Positives = 89/210 (42%), Gaps = 26/210 (12%) Query: 60 KVIGNGSFGVVYQAKLCDSGELVAIK--KVLQDKRFKNRELQIMRKL---DH-CNIVRLR 113 K IG G FG +Y+A + E VA+K Q K+ E+ +++KL DH C + Sbjct: 62 KKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDHVCRFI--- 118 Query: 114 YFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIH 173 G ++E + +V+ + + R R TL ++L Q+ S+ IH Sbjct: 119 ------GCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTT-LRLGK-QILESIEAIH 170 Query: 174 SFGICHRDIKPQNLLLDPDTAVLKLC---DFGSAKQL------VRGEPNVSYICSRYYRA 224 S G HRDIKP N + + + C DFG A+Q VR NV+ A Sbjct: 171 SVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRYA 230 Query: 225 PELIFGATDYTSSIDVWSAGCVLAELLLGQ 254 + D+WS +L E +GQ Sbjct: 231 SVNAHKNREMGRHDDLWSLFYMLVEFAVGQ 260 >4HZS-A nrPDB Length = 341 Score = 52.4 bits (124), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 72/284 (25%), Positives = 117/284 (41%), Gaps = 43/284 (15%) Query: 62 IGNGSFGVVYQAKL-CDSGELVAIK-KVLQDKRFKN--------RELQIMRKLDHCNIVR 111 +G+GSFGVV + + SG+ V++ K L+ RE+ M LDH N++R Sbjct: 20 LGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNLIR 79 Query: 112 LRYFFYSSGEKKDEVYLNLVLDYVP--ETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 169 L + K +V + P + R+ +H + + Y Q+ + Sbjct: 80 LYGVVLTPPMK-------MVTELAPLGSLLDRLRKHQGH----FLLGTLSRYAVQVAEGM 128 Query: 170 AYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYR------ 223 Y+ S HRD+ +NLLL ++K+ DFG + L + + + Y+ + + Sbjct: 129 GYLESKRFIHRDLAARNLLL-ATRDLVKIGDFGLMRALPQNDDH--YVMQEHRKVPFAWC 185 Query: 224 APELIFGATDYTSSIDVWSAGCVLAELL-LGQPIFPGDSGVDQLVEIIKVLGTPTREQIR 282 APE + T ++ + D W G L E+ GQ + G +G L +I K E R Sbjct: 186 APESLKTRT-FSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDK-------EGER 237 Query: 283 EMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPT 326 P + W +P P +AL LLE PT Sbjct: 238 LPRPEDCPQDIYNVMVQCWAH--KPEDRPTFVALRDFLLEAQPT 279 >2H34-A nrPDB Length = 309 Score = 52.0 bits (123), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 58/214 (27%), Positives = 97/214 (45%), Gaps = 20/214 (9%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ----DKRFK---NRELQIMRKLDHCN 108 Y +++G G G VY+A+ +VA+K + + D F+ RE + +L + Sbjct: 36 YRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRTRMQREARTAGRLQEPH 95 Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRS 168 +V + F GE ++Y+++ L + + R A I + Q+ + Sbjct: 96 VVPIHDF----GEIDGQLYVDMRLINGVDLAAMLRRQGPLAPPRAVAI-----VRQIGSA 146 Query: 169 LAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNV--SYICSRYYRAPE 226 L H+ G HRD+KP+N+L+ D L DFG A + + + + YY APE Sbjct: 147 LDAAHAAGATHRDVKPENILVSADDFAY-LVDFGIASATTDEKLTQLGNTVGTLYYMAPE 205 Query: 227 LIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGD 260 F + T D+++ CVL E L G P + GD Sbjct: 206 R-FSESHATYRADIYALTCVLYECLTGSPPYQGD 238 >4NFN-A nrPDB Length = 309 Score = 52.0 bits (123), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 59/210 (28%), Positives = 89/210 (42%), Gaps = 26/210 (12%) Query: 60 KVIGNGSFGVVYQAKLCDSGELVAIK--KVLQDKRFKNRELQIMRKL---DH-CNIVRLR 113 K IG G FG +Y+A + E VA+K Q K+ E+ +++KL DH C + Sbjct: 27 KKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDHVCRFI--- 83 Query: 114 YFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIH 173 G ++E + +V+ + + R R TL ++L Q+ S+ IH Sbjct: 84 ------GCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTT-LRLGK-QILESIEAIH 135 Query: 174 SFGICHRDIKPQNLLLDPDTAVLKLC---DFGSAKQL------VRGEPNVSYICSRYYRA 224 S G HRDIKP N + + + C DFG A+Q VR NV+ A Sbjct: 136 SVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRYA 195 Query: 225 PELIFGATDYTSSIDVWSAGCVLAELLLGQ 254 + D+WS +L E +GQ Sbjct: 196 SVNAHKNREMGRHDDLWSLFYMLVEFAVGQ 225 >1U54-B nrPDB Length = 291 Score = 52.0 bits (123), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 73/284 (25%), Positives = 116/284 (40%), Gaps = 43/284 (15%) Query: 62 IGNGSFGVVYQAKL-CDSGELVAIK-KVLQDKRFKN--------RELQIMRKLDHCNIVR 111 +G+GSFGVV + + SG+ V++ K L+ RE+ M LDH N++R Sbjct: 26 LGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNLIR 85 Query: 112 LRYFFYSSGEKKDEVYLNLVLDYVP--ETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 169 L + K +V + P + R+ +H + + Y Q+ + Sbjct: 86 LYGVVLTPPMK-------MVTELAPLGSLLDRLRKHQGH----FLLGTLSRYAVQVAEGM 134 Query: 170 AYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYR------ 223 Y+ S HRD+ +NLLL V K+ DFG + L + + + Y+ + + Sbjct: 135 GYLESKRFIHRDLAARNLLLATRDLV-KIGDFGLMRALPQNDDH--YVMQEHRKVPFAWC 191 Query: 224 APELIFGATDYTSSIDVWSAGCVLAELL-LGQPIFPGDSGVDQLVEIIKVLGTPTREQIR 282 APE + T ++ + D W G L E+ GQ + G +G L +I K E R Sbjct: 192 APESLKTRT-FSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDK-------EGER 243 Query: 283 EMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPT 326 P + W +P P +AL LLE PT Sbjct: 244 LPRPEDCPQDIYNVMVQCWAH--KPEDRPTFVALRDFLLEAQPT 285 >2WTK-B nrPDB Length = 373 Score = 52.0 bits (123), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 69/336 (20%), Positives = 123/336 (36%), Gaps = 58/336 (17%) Query: 51 PQEVSYTDTKVIGNG--SFGVVYQAKLCDSGELVAIKKVLQDK------RFKNRELQIMR 102 P+ Y VIG G V A+ +GE V ++++ + F EL + + Sbjct: 6 PEGGCYELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSK 65 Query: 103 KLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYR--VARHYSRAKQTLPVIYVKL 160 +H NIV R F + E L +V ++ + + H+ L + Y+ Sbjct: 66 LFNHPNIVPYRATFIADNE------LWVVTSFMAYGSAKDLICTHFMDGMNELAIAYI-- 117 Query: 161 YMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAV--------LKLCDFGSAKQLVRGEP 212 + + ++L YIH G HR +K ++L+ D V L + G +++V P Sbjct: 118 -LQGVLKALDYIHHMGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFP 176 Query: 213 NVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEII-- 270 S + L Y + D++S G EL G F L+E + Sbjct: 177 KYSVKVLPWLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNG 236 Query: 271 --------------KVLGTPTR--------EQIREMNPNYTEFKFPQIKAHPWTKVFRPR 308 ++ +P+R + + P + P +HP+ + F P Sbjct: 237 TVPCLLDTSTIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSP---SHPYHRTFSPH 293 Query: 309 TPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELR 344 + L+ P AR + HSFF +++ Sbjct: 294 FH----HFVEQCLQRNPDARPSASTLLNHSFFKQIK 325 >2DQ7-X nrPDB Length = 283 Score = 52.0 bits (123), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 61/221 (27%), Positives = 105/221 (47%), Gaps = 27/221 (12%) Query: 60 KVIGNGSFGVVYQAKLCDSGELVAIKKV----LQDKRFKNRELQIMRKLDHCNIVRLRYF 115 K +GNG FG V+ + VAIK + + + F E QIM+KL H +V+L Sbjct: 15 KRLGNGQFGEVWMGT-WNGNTKVAIKTLKPGTMSPESFL-EEAQIMKKLKHDKLVQLYAV 72 Query: 116 FYSSGEKKDEVYLNL--VLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIH 173 Y+N +LD++ + R + LP + V + Q+ +AYI Sbjct: 73 VSEEPIYIVTEYMNKGSLLDFLKDGEGRALK--------LPNL-VDM-AAQVAAGMAYIE 122 Query: 174 SFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY---YRAPE-LIF 229 HRD++ N+L+ + + K+ DFG A+ L+ + +++ + APE ++ Sbjct: 123 RMNYIHRDLRSANILVG-NGLICKIADFGLAR-LIEDNEYTARQGAKFPIKWTAPEAALY 180 Query: 230 GATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEI 269 G +T DVWS G +L EL+ G+ +PG + + L ++ Sbjct: 181 GR--FTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQV 219 >3LM0-A nrPDB Length = 327 Score = 52.0 bits (123), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 58/257 (22%), Positives = 109/257 (42%), Gaps = 49/257 (19%) Query: 59 TKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN------RELQIMRKLDHC-NIVR 111 +K +G G F VV Q +G+ A K + + +R ++ E+ ++ C ++ Sbjct: 34 SKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELAKSCPRVIN 93 Query: 112 LRYFFYSSGEKKDEVYLNLVLDY----------VPETVYRVARHYSRAKQTLPVIYVKLY 161 L + ++ E + L+L+Y +PE V+ + VI + Sbjct: 94 LHEVYENTSE------IILILEYAAGGEIFSLCLPELAEMVSEN--------DVIRL--- 136 Query: 162 MYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAV--LKLCDFGSAKQLVRGEPNVSYICS 219 + Q+ + Y+H I H D+KPQN+LL + +K+ DFG ++++ + + Sbjct: 137 IKQILEGVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACELREIMGT 196 Query: 220 RYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTRE 279 Y APE I T++ D+W+ G + LL F G+ + T Sbjct: 197 PEYLAPE-ILNYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQE------------TYL 243 Query: 280 QIREMNPNYTEFKFPQI 296 I ++N +Y+E F + Sbjct: 244 NISQVNVDYSEETFSSV 260 >3SOC-A nrPDB Length = 322 Score = 52.0 bits (123), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 59/221 (26%), Positives = 97/221 (43%), Gaps = 49/221 (22%) Query: 60 KVIGNGSFGVVYQAKLCDSGELVAIKKV-LQDKRFKNRELQI--MRKLDHCNIVR----- 111 +V G FG V++A+L + E VA+K +QDK+ E ++ + + H NI++ Sbjct: 30 EVKARGRFGCVWKAQLLN--EYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAE 87 Query: 112 -----------LRYFFYSSGEKKDEVYLNLV----LDYVPETVYRVARHYSRAKQTLPVI 156 L F+ G D + N+V L ++ ET+ R Sbjct: 88 KRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLA------------ 135 Query: 157 YVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEP---N 213 Y+++ L H I HRDIK +N+LL + + DFG A + G+ Sbjct: 136 ----YLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTAC-IADFGLALKFEAGKSAGDT 190 Query: 214 VSYICSRYYRAPELIFGATDYTSS----IDVWSAGCVLAEL 250 + +R Y APE++ GA ++ ID+++ G VL EL Sbjct: 191 HGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWEL 231 >2Y6O-A nrPDB Length = 291 Score = 51.6 bits (122), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 55/205 (26%), Positives = 89/205 (43%), Gaps = 24/205 (11%) Query: 60 KVIGNGSFGVVYQAKLCDSGE---LVAIKKVLQDKRFKNR-----ELQIMRKLDHCNIVR 111 KVIG G FG V +L G+ VAIK + K R E IM + DH NI+ Sbjct: 20 KVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHPNIIH 79 Query: 112 LRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAY 171 L + ++ +Y+ + + T VI + + + + Y Sbjct: 80 LEGVVTKCKP------VMIITEYMENGSLDAFLRKNDGRFT--VIQLVGMLRGIGSGMKY 131 Query: 172 IHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSR-----YYRAPE 226 + HRD+ +N+L++ + V K+ DFG ++ L +P +Y + APE Sbjct: 132 LSDMSYVHRDLAARNILVNSNL-VCKVSDFGMSRVL-EDDPEAAYTTRGGKIPIRWTAPE 189 Query: 227 LIFGATDYTSSIDVWSAGCVLAELL 251 I +TS+ DVWS G V+ E++ Sbjct: 190 AI-AYRKFTSASDVWSYGIVMWEVM 213 >5FQD-C nrPDB Length = 341 Score = 51.6 bits (122), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 48/158 (30%), Positives = 77/158 (48%), Gaps = 18/158 (11%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKL-----DHCNIV 110 Y + IG+GSFG +Y A +GE VA+K L+ ++ ++ +L KL I Sbjct: 21 YKLVRKIGSGSFGDIYLAINITNGEEVAVK--LESQKARHPQLLYESKLYKILQGGVGIP 78 Query: 111 RLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLA 170 +R++ G++KD Y LV+D + ++ + SR V+ + Q+ + Sbjct: 79 HIRWY----GQEKD--YNVLVMDLLGPSLEDLFNFCSRRFTMKTVL---MLADQMISRIE 129 Query: 171 YIHSFGICHRDIKPQNLLLDPDTAV--LKLCDFGSAKQ 206 Y+H+ HRDIKP N L+ L L DFG AK+ Sbjct: 130 YVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKK 167 >2FO0-A nrPDB Length = 495 Score = 51.2 bits (121), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 60/237 (25%), Positives = 114/237 (48%), Gaps = 37/237 (15%) Query: 53 EVSYTDTKV---IGNGSFGVVYQAKLCDSGELVAIKKVLQD----KRFKNRELQIMRKLD 105 E+ TD + +G G +G VY+ VA+K + +D + F +E +M+++ Sbjct: 213 EMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFL-KEAAVMKEIK 271 Query: 106 HCNIVRLRYF------FYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVK 159 H N+V+L FY E Y NL LDY+ E +Q + + V Sbjct: 272 HPNLVQLLGVCTREPPFYIITEFM--TYGNL-LDYLREC----------NRQEVNAV-VL 317 Query: 160 LYM-YQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYIC 218 LYM Q+ ++ Y+ HR++ +N L+ + ++K+ DFG ++ L+ G+ ++ Sbjct: 318 LYMATQISSAMEYLEKKNFIHRNLAARNCLVG-ENHLVKVADFGLSR-LMTGDTYTAHAG 375 Query: 219 SRY---YRAPELIFGATDYTSSIDVWSAGCVLAEL-LLGQPIFPGDSGVDQLVEIIK 271 +++ + APE + ++ DVW+ G +L E+ G +PG + Q+ E+++ Sbjct: 376 AKFPIKWTAPESL-AYNKFSIKSDVWAFGVLLWEIATYGMSPYPGID-LSQVYELLE 430 >4FL3-A nrPDB Length = 635 Score = 51.2 bits (121), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 76/281 (27%), Positives = 121/281 (43%), Gaps = 44/281 (15%) Query: 38 TTVVATPGQGPD--RPQEVSYTDTKVI-------GNGSFGVV----YQAKLCDSGELVAI 84 T V +P P+ RP+EV Y D K++ G+G+FG V YQ K V I Sbjct: 345 TEVFESPFADPEEIRPKEV-YLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKI 403 Query: 85 -KKVLQDKRFKNR---ELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVY 140 K D K+ E +M++LD+ IVR+ E + + + + + P Y Sbjct: 404 LKNEANDPALKDELLAEANVMQQLDNPYIVRM----IGICEAESWMLVMEMAELGPLNKY 459 Query: 141 RVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCD 200 + + K + +++ Q+ + Y+ HRD+ +N+LL K+ D Sbjct: 460 LQQNRHVKDKNIIELVH------QVSMGMKYLEESNFVHRDLAARNVLLVTQHYA-KISD 512 Query: 201 FGSAKQLVRGEPNVSYICSRY------YRAPELIFGATDYTSSIDVWSAGCVLAELL-LG 253 FG +K L R + N Y + + APE I ++S DVWS G ++ E G Sbjct: 513 FGLSKAL-RADENY-YKAQTHGKWPVKWYAPECI-NYYKFSSKSDVWSFGVLMWEAFSYG 569 Query: 254 QPIFPGDSG--VDQLVEIIKVLGTPT---REQIREMNPNYT 289 Q + G G V ++E + +G P RE MN +T Sbjct: 570 QKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWT 610 >2VWV-A nrPDB Length = 302 Score = 51.2 bits (121), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 54/214 (25%), Positives = 96/214 (44%), Gaps = 25/214 (11%) Query: 53 EVSYTDTK-VIGNGSFGVVYQAKLCDSGE---LVAIKKVLQDKRFKNR-----ELQIMRK 103 +VSY + VIG G FG V + +L G+ VAIK + + R E IM + Sbjct: 14 DVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSEASIMGQ 73 Query: 104 LDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMY 163 +H NI+RL G + + + ++ +++ + + T VI + + Sbjct: 74 FEHPNIIRL------EGVVTNSMPVMILTEFMENGALDSFLRLNDGQFT--VIQLVGMLR 125 Query: 164 QLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSR--- 220 + + Y+ HRD+ +N+L++ + V K+ DFG ++ L + + S Sbjct: 126 GIASGMRYLAEMSYVHRDLAARNILVNSNL-VCKVSDFGLSRFLEENSSDPTETSSLGGK 184 Query: 221 ---YYRAPELIFGATDYTSSIDVWSAGCVLAELL 251 + APE I +TS+ D WS G V+ E++ Sbjct: 185 IPIRWTAPEAI-AFRKFTSASDAWSYGIVMWEVM 217 >4LRM-A nrPDB Length = 334 Score = 51.2 bits (121), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 58/229 (25%), Positives = 98/229 (42%), Gaps = 35/229 (15%) Query: 45 GQGPDRP-----QEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKR-----FK 94 G+ P++ +E + KV+G+G+FG VY+ GE V I +++ R Sbjct: 5 GEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKA 64 Query: 95 NREL----QIMRKLD---HCNIVRLRYFFYSSGEK--KDEVYLNLVLDYVPETVYRVARH 145 N+E+ +M +D + ++ RL +S + + +LDYV E Sbjct: 65 NKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVRE-------- 116 Query: 146 YSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAK 205 K + Y+ + Q+ + + Y+ + HRD+ +N+L+ V K+ DFG AK Sbjct: 117 ---HKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHV-KITDFGLAK 172 Query: 206 QLVRGEPNVSYICSRY---YRAPELIFGATDYTSSIDVWSAGCVLAELL 251 L E + + A E I YT DVWS G + EL+ Sbjct: 173 LLGAEEKEYHAEGGKVPIKWMALESILHRI-YTHQSDVWSYGVTVWELM 220 >6NPU-A nrPDB Length = 298 Score = 51.2 bits (121), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 58/225 (25%), Positives = 109/225 (48%), Gaps = 34/225 (15%) Query: 62 IGNGSFGVVYQAKLCDSGELVAIKKVLQD----KRFKNRELQIMRKLDHCNIVRLRYF-- 115 +G G +G VY+ VA+K + +D + F +E +M+++ H N+V+L Sbjct: 34 LGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFL-KEAAVMKEIKHPNLVQLLGVCT 92 Query: 116 ----FYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYM-YQLFRSLA 170 FY E Y NL LDY+ E +Q + + V LYM Q+ ++ Sbjct: 93 REPPFYIITEFM--TYGNL-LDYLREC----------NRQEVNAV-VLLYMATQISSAME 138 Query: 171 YIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY---YRAPEL 227 Y+ HRD+ +N L+ + ++K+ DFG ++ L+ G+ ++ +++ + APE Sbjct: 139 YLEKKNFIHRDLAARNCLVG-ENHLVKVADFGLSR-LMTGDTYTAHAGAKFPIKWTAPES 196 Query: 228 IFGATDYTSSIDVWSAGCVLAEL-LLGQPIFPGDSGVDQLVEIIK 271 + ++ DVW+ G +L E+ G +PG + Q+ E+++ Sbjct: 197 L-AYNKFSIKSDVWAFGVLLWEIATYGMSPYPGID-LSQVYELLE 239 >4XUF-A nrPDB Length = 297 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 63/233 (27%), Positives = 106/233 (45%), Gaps = 39/233 (16%) Query: 60 KVIGNGSFGVVYQAK---LCDSGELVAIK-KVLQDKRFKNR------ELQIMRKL-DHCN 108 KV+G+G+FG V A + +G + + K+L++K + EL++M +L H N Sbjct: 15 KVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHEN 74 Query: 109 IVRLRYFFYSSGEKKDEVYLNL-------VLDYV---------PETVYRVARHYSRAKQT 152 IV L SG +YL +L+Y+ E Y + + Sbjct: 75 IVNLLGACTLSGP----IYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRLEEEEDL 130 Query: 153 LPVIYVKL--YMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRG 210 + + L + YQ+ + + ++ HRD+ +N+L+ V+K+CDFG A+ ++ Sbjct: 131 NVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLV-THGKVVKICDFGLARDIMSD 189 Query: 211 EPNVSYICSRY---YRAPELIFGATDYTSSIDVWSAGCVLAELL-LGQPIFPG 259 V +R + APE +F YT DVWS G +L E+ LG +PG Sbjct: 190 SNYVVRGNARLPVKWMAPESLFEGI-YTIKSDVWSYGILLWEIFSLGVNPYPG 241 >2OZO-A nrPDB Length = 613 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 61/207 (29%), Positives = 94/207 (45%), Gaps = 34/207 (16%) Query: 62 IGNGSFGVVYQA--KLCDSGELVAIKKVLQ-----DKRFKNRELQIMRKLDHCNIVRLRY 114 +G G+FG V Q ++ VAIK + Q D RE QIM +LD+ IVRL Sbjct: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRL-- 401 Query: 115 FFYSSGEKKDEVYLNLVLDYV---PETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAY 171 G + E L LV++ P + V + ++ +PV V ++Q+ + Y Sbjct: 402 ----IGVCQAEA-LMLVMEMAGGGPLHKFLVGK-----REEIPVSNVAELLHQVSMGMKY 451 Query: 172 IHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSR-------YYRA 224 + HR++ +N+LL + K+ DFG +K L + SY +R + A Sbjct: 452 LEEKNFVHRNLAARNVLL-VNRHYAKISDFGLSKALGADD---SYYTARSAGKWPLKWYA 507 Query: 225 PELIFGATDYTSSIDVWSAGCVLAELL 251 PE I ++S DVWS G + E L Sbjct: 508 PECI-NFRKFSSRSDVWSYGVTMWEAL 533 >4RT7-A nrPDB Length = 415 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 33/103 (32%), Positives = 54/103 (52%), Gaps = 6/103 (5%) Query: 161 YMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSR 220 + YQ+ + + ++ HRD+ +N+L+ V+K+CDFG A+ ++ V +R Sbjct: 248 FAYQVAKGMEFLEFKSCVHRDLAARNVLV-THGKVVKICDFGLARDIMSDSNYVVRGNAR 306 Query: 221 Y---YRAPELIFGATDYTSSIDVWSAGCVLAELL-LGQPIFPG 259 + APE +F YT DVWS G +L E+ LG +PG Sbjct: 307 LPVKWMAPESLFEGI-YTIKSDVWSYGILLWEIFSLGVNPYPG 348 >5X02-A nrPDB Length = 347 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 63/233 (27%), Positives = 106/233 (45%), Gaps = 39/233 (16%) Query: 60 KVIGNGSFGVVYQAK---LCDSGELVAIK-KVLQDKRFKNR------ELQIMRKL-DHCN 108 KV+G+G+FG V A + +G + + K+L++K + EL++M +L H N Sbjct: 54 KVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHEN 113 Query: 109 IVRLRYFFYSSGEKKDEVYLNL-------VLDYV---------PETVYRVARHYSRAKQT 152 IV L SG +YL +L+Y+ E Y + + Sbjct: 114 IVNLLGACTLSGP----IYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRLEEEEDL 169 Query: 153 LPVIYVKL--YMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRG 210 + + L + YQ+ + + ++ HRD+ +N+L+ V+K+CDFG A+ ++ Sbjct: 170 NVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLV-THGKVVKICDFGLARDIMSD 228 Query: 211 EPNVSYICSRY---YRAPELIFGATDYTSSIDVWSAGCVLAELL-LGQPIFPG 259 V +R + APE +F YT DVWS G +L E+ LG +PG Sbjct: 229 SNYVVRGNARLPVKWMAPESLFEGI-YTIKSDVWSYGILLWEIFSLGVNPYPG 280 >1U59-A nrPDB Length = 287 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 62/207 (29%), Positives = 94/207 (45%), Gaps = 34/207 (16%) Query: 62 IGNGSFGVVYQA--KLCDSGELVAIKKVLQ-----DKRFKNRELQIMRKLDHCNIVRLRY 114 +G G+FG V Q ++ VAIK + Q D RE QIM +LD+ IVRL Sbjct: 18 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRL-- 75 Query: 115 FFYSSGEKKDEVYLNLVLDYV---PETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAY 171 G + E L LV++ P + V + ++ +PV V ++Q+ + Y Sbjct: 76 ----IGVCQAEA-LMLVMEMAGGGPLHKFLVGK-----REEIPVSNVAELLHQVSMGMKY 125 Query: 172 IHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSR-------YYRA 224 + HRD+ +N+LL + K+ DFG +K L + SY +R + A Sbjct: 126 LEEKNFVHRDLAARNVLL-VNRHYAKISDFGLSKAL---GADDSYYTARSAGKWPLKWYA 181 Query: 225 PELIFGATDYTSSIDVWSAGCVLAELL 251 PE I ++S DVWS G + E L Sbjct: 182 PECI-NFRKFSSRSDVWSYGVTMWEAL 207 >4R7H-A nrPDB Length = 343 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 34/100 (34%), Positives = 54/100 (54%), Gaps = 6/100 (6%) Query: 164 QLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY-- 221 Q+ + +A++ S HRD+ +N+LL + V K+ DFG A+ ++ + +R Sbjct: 185 QVAQGMAFLASKNCIHRDVAARNVLL-TNGHVAKIGDFGLARDIMNDSNYIVKGNARLPV 243 Query: 222 -YRAPELIFGATDYTSSIDVWSAGCVLAELL-LGQPIFPG 259 + APE IF + YT DVWS G +L E+ LG +PG Sbjct: 244 KWMAPESIFDSV-YTVQSDVWSYGILLWEIFSLGLNPYPG 282 >3ZBF-A nrPDB Length = 322 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 59/229 (25%), Positives = 98/229 (42%), Gaps = 30/229 (13%) Query: 61 VIGNGSFGVVYQAKLCD-----SGELVAIKKVL------QDKRFKNRELQIMRKLDHCNI 109 ++G+G+FG VY+ D SGE+ K L Q+K +E +M K +H NI Sbjct: 40 LLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNI 99 Query: 110 VRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 169 L+ + + L L+ T R AR + L ++ + + + Sbjct: 100 --LKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGC 157 Query: 170 AYIHSFGICHRDIKPQNLLLDPDT----AVLKLCDFGSAKQLV-------RGEPNVSYIC 218 Y+ HRD+ +N L+ ++K+ DFG A+ + RGE + Sbjct: 158 VYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEG----LL 213 Query: 219 SRYYRAPELIFGATDYTSSIDVWSAGCVLAELL-LGQPIFPGDSGVDQL 266 + APE + +T+ DVWS G ++ E+L LG +P S +D L Sbjct: 214 PVRWMAPESLMDGI-FTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVL 261 >3G2F-A nrPDB Length = 336 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 80/317 (25%), Positives = 136/317 (42%), Gaps = 52/317 (16%) Query: 60 KVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRK--LDHCNIVRLRYFFY 117 ++IG G +G VY+ L + V + + F N E I R ++H NI R F Sbjct: 19 ELIGRGRYGAVYKGSLDERPVAVKVFSFANRQNFIN-EKNIYRVPLMEHDNIAR----FI 73 Query: 118 SSGEK---KDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHS 174 E+ + LV++Y P + ++ S T + + + R LAY+H+ Sbjct: 74 VGDERVTADGRMEYLLVMEYYPNG--SLCKYLS--LHTSDWVSSCRLAHSVTRGLAYLHT 129 Query: 175 F---------GICHRDIKPQNLLLDPDTAVLKLCDFG-----SAKQLVR-GEPN---VSY 216 I HRD+ +N+L+ D + + DFG + +LVR GE + +S Sbjct: 130 ELPRGDHYKPAISHRDLNSRNVLVKNDGTCV-ISDFGLSMRLTGNRLVRPGEEDNAAISE 188 Query: 217 ICSRYYRAPELIFGATDY------TSSIDVWSAGCVLAELLL-GQPIFPGDSGVD-QLVE 268 + + Y APE++ GA + +D+++ G + E+ + +FPG+S + Q+ Sbjct: 189 VGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVPEYQMAF 248 Query: 269 IIKVLGTPTREQIREMNPNYTEF-KFPQIKAHPWTK-VFRPRTPPEAIALCSRLLEYTPT 326 +V PT E ++ + + KFP+ W + R+ E I C + Sbjct: 249 QTEVGNHPTFEDMQVLVSREKQRPKFPE----AWKENSLAVRSLKETIEDC---WDQDAE 301 Query: 327 ARLTPLEACAHSFFDEL 343 ARLT CA EL Sbjct: 302 ARLTA--QCAEERMAEL 316 >4Y83-A nrPDB Length = 332 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 52/216 (24%), Positives = 97/216 (44%), Gaps = 32/216 (14%) Query: 51 PQEVSYTD--TKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCN 108 P +++Y + + I G+FG VY A+ + + +A K + D+ FK +++I H N Sbjct: 68 PWKLTYRNIGSDFIPRGAFGKVYLAQDIKTKKRMACKLIPVDQ-FKPSDVEIQACFRHEN 126 Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRS 168 I L Y + + V+L + + ++ + +I+V + + + Sbjct: 127 IAEL----YGAVLWGETVHLFMEAGEGGSVLEKLES--CGPMREFEIIWVTKH---VLKG 177 Query: 169 LAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQL---------VRGEPNVSYICS 219 L ++HS + H DIKP N++ AV L DFG + Q+ +RG + Sbjct: 178 LDFLHSKKVIHHDIKPSNIVFMSTKAV--LVDFGLSVQMTEDVYFPKDLRG--------T 227 Query: 220 RYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQP 255 Y +PE+I +++ D++S G L + G P Sbjct: 228 EIYMSPEVIL-CRGHSTKADIYSLGATLIHMQTGTP 262 >5C26-A nrPDB Length = 299 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 79/284 (27%), Positives = 124/284 (43%), Gaps = 50/284 (17%) Query: 38 TTVVATPGQGPD--RPQEVSYTDTKVI-------GNGSFGVV----YQAKLCDSGELVAI 84 T V +P P+ RP+EV Y D K++ G+G+FG V YQ K V I Sbjct: 3 TEVYESPYADPEEIRPKEV-YLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKI 61 Query: 85 -KKVLQDKRFKNR---ELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYV---PE 137 K D K+ E +M++LD+ IVR+ G + E ++ LV++ P Sbjct: 62 LKNEANDPALKDELLAEANVMQQLDNPYIVRM------IGICEAESWM-LVMEMAELGPL 114 Query: 138 TVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLK 197 Y + + K + +++ Q+ + Y+ HRD+ +N+LL K Sbjct: 115 NKYLQQNRHVKDKNIIELVH------QVSMGMKYLEESNFVHRDLAARNVLLVTQHYA-K 167 Query: 198 LCDFGSAKQLVRGEPNVSYICSRY------YRAPELIFGATDYTSSIDVWSAGCVLAELL 251 + DFG +K L R + N Y + + APE I ++S DVWS G ++ E Sbjct: 168 ISDFGLSKAL-RADENY-YKAQTHGKWPVKWYAPECI-NYYKFSSKSDVWSFGVLMWEAF 224 Query: 252 -LGQPIFPGDSG--VDQLVEIIKVLGTPT---REQIREMNPNYT 289 GQ + G G V ++E + +G P RE MN +T Sbjct: 225 SYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWT 268 >2OGV-A nrPDB Length = 317 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 63/225 (28%), Positives = 95/225 (42%), Gaps = 36/225 (16%) Query: 60 KVIGNGSFGVVYQAKLCDSGELVAIKKVL----------QDKRFKNRELQIMRKL-DHCN 108 K +G G+FG V +A G+ A+ KV +K EL+IM L H N Sbjct: 44 KTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHEN 103 Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAK----------QTLPVIYV 158 IV L G VL Y ++ R K + L + + Sbjct: 104 IVNLLGACTHGGP---------VLVITEYCCYGDLLNFLRRKAEADLDKEDGRPLELRDL 154 Query: 159 KLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYIC 218 + Q+ + +A++ S HRD+ +N+LL + V K+ DFG A+ ++ + Sbjct: 155 LHFSSQVAQGMAFLASKNCIHRDVAARNVLL-TNGHVAKIGDFGLARDIMNDSNYIVKGN 213 Query: 219 SRY---YRAPELIFGATDYTSSIDVWSAGCVLAELL-LGQPIFPG 259 +R + APE IF YT DVWS G +L E+ LG +PG Sbjct: 214 ARLPVKWMAPESIFDCV-YTVQSDVWSYGILLWEIFSLGLNPYPG 257 >2HK5-A nrPDB Length = 270 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 55/212 (25%), Positives = 104/212 (49%), Gaps = 25/212 (11%) Query: 60 KVIGNGSFGVVYQAKLCDSGELVAIKKV----LQDKRFKNRELQIMRKLDHCNIVRLRYF 115 K +G G FG V+ A + VA+K + + + F E +M+ L H +V+L Sbjct: 21 KKLGAGQFGEVWMATYNKHTK-VAVKTMKPGSMSVEAFLA-EANVMKTLQHDKLVKLHAV 78 Query: 116 FYSSGEKKDEVYLNLVLDYVPE-TVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHS 174 K+ +Y+ + +++ + ++ + +KQ LP + + Q+ +A+I Sbjct: 79 V-----TKEPIYI--ITEFMAKGSLLDFLKSDEGSKQPLPKLID--FSAQIAEGMAFIEQ 129 Query: 175 FGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY---YRAPELI-FG 230 HRD++ N+L+ + V K+ DFG A+ ++ + +++ + APE I FG Sbjct: 130 RNYIHRDLRAANILVSA-SLVCKIADFGLAR-VIEDNEYTAREGAKFPIKWTAPEAINFG 187 Query: 231 ATDYTSSIDVWSAGCVLAELL-LGQPIFPGDS 261 + +T DVWS G +L E++ G+ +PG S Sbjct: 188 S--FTIKSDVWSFGILLMEIVTYGRIPYPGMS 217 >3SV0-A nrPDB Length = 483 Score = 49.7 bits (117), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 48/154 (31%), Positives = 75/154 (48%), Gaps = 18/154 (11%) Query: 60 KVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNREL----QIMRKLDH-CNIVRLRY 114 + IG+GSFG +Y + E VAIK L++ + K+ +L +I R L I +R+ Sbjct: 13 RKIGSGSFGEIYLGTNIQTNEEVAIK--LENVKTKHPQLLYESKIYRILQGGTGIPNVRW 70 Query: 115 FFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHS 174 F G + D Y LV+D + ++ + SR L + V + Q+ + ++HS Sbjct: 71 F----GVEGD--YNVLVMDLLGPSLEDLFNFCSR---KLSLKTVLMLADQMINRVEFVHS 121 Query: 175 FGICHRDIKPQNLL--LDPDTAVLKLCDFGSAKQ 206 HRDIKP N L L + + DFG AK+ Sbjct: 122 KSFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKK 155 >3KRL-A nrPDB Length = 335 Score = 48.9 bits (115), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 34/100 (34%), Positives = 53/100 (53%), Gaps = 6/100 (6%) Query: 164 QLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY-- 221 Q+ + +A++ S HRD+ +N+LL + V K+ DFG A+ ++ + +R Sbjct: 174 QVAQGMAFLASKNCIHRDVAARNVLL-TNGHVAKIGDFGLARDIMNDSNYIVKGNARLPV 232 Query: 222 -YRAPELIFGATDYTSSIDVWSAGCVLAELL-LGQPIFPG 259 + APE IF YT DVWS G +L E+ LG +PG Sbjct: 233 KWMAPESIFDCV-YTVQSDVWSYGILLWEIFSLGLNPYPG 271 >2H8H-A nrPDB Length = 535 Score = 48.9 bits (115), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 57/214 (26%), Positives = 100/214 (46%), Gaps = 37/214 (17%) Query: 62 IGNGSFGVVYQAKLCDSGELVAIKKV----LQDKRFKNRELQIMRKLDHCNIVRLRYFFY 117 +G G FG V+ + VAIK + + + F +E Q+M+KL H +V+L Y Sbjct: 275 LGQGCFGEVWMGTW-NGTTRVAIKTLKPGTMSPEAFL-QEAQVMKKLRHEKLVQL-YAVV 331 Query: 118 SSGEKKDEVYL-------NLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLA 170 S ++ +Y+ +LD++ + Y R Q + + Q+ +A Sbjct: 332 S----EEPIYIVTEYMSKGSLLDFLKGETGK----YLRLPQLVDM------AAQIASGMA 377 Query: 171 YIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY---YRAPE- 226 Y+ HRD++ N+L+ + V K+ DFG A+ L+ + +++ + APE Sbjct: 378 YVERMNYVHRDLRAANILVG-ENLVCKVADFGLAR-LIEDNEYTARQGAKFPIKWTAPEA 435 Query: 227 LIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPG 259 ++G +T DVWS G +L EL G+ +PG Sbjct: 436 ALYGR--FTIKSDVWSFGILLTELTTKGRVPYPG 467 >1JPA-A nrPDB Length = 312 Score = 48.9 bits (115), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 51/206 (24%), Positives = 88/206 (42%), Gaps = 24/206 (11%) Query: 60 KVIGNGSFGVVYQAKLCDSGE---LVAIKKVLQDKRFKNR-----ELQIMRKLDHCNIVR 111 +VIG G FG V L G+ VAIK + K R E IM + DH N++ Sbjct: 39 QVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIH 98 Query: 112 LRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAY 171 L G + ++ +++ + + VI + + + + Y Sbjct: 99 LE------GVVTKSTPVMIITEFMENG--SLDSFLRQNDGQFTVIQLVGMLRGIAAGMKY 150 Query: 172 IHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSR------YYRAP 225 + HRD+ +N+L++ + V K+ DFG ++ L + +Y + + AP Sbjct: 151 LADMNYVHRDLAARNILVNSNL-VCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAP 209 Query: 226 ELIFGATDYTSSIDVWSAGCVLAELL 251 E I +TS+ DVWS G V+ E++ Sbjct: 210 EAI-QYRKFTSASDVWSYGIVMWEVM 234 >1AD5-A nrPDB Length = 438 Score = 48.5 bits (114), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 55/212 (25%), Positives = 102/212 (48%), Gaps = 35/212 (16%) Query: 60 KVIGNGSFGVVYQAKLCDSGELVAIKKV----LQDKRFKNRELQIMRKLDHCNIVRLRYF 115 K +G G FG V+ A + VA+K + + + F E +M+ L H +V+L Sbjct: 188 KKLGAGQFGEVWMATYNKHTK-VAVKTMKPGSMSVEAFLA-EANVMKTLQHDKLVKLHAV 245 Query: 116 FYSSGEKKDEVYLNLVLDYVPE-TVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHS 174 K+ +Y+ + +++ + ++ + +KQ LP + + Q+ +A+I Sbjct: 246 V-----TKEPIYI--ITEFMAKGSLLDFLKSDEGSKQPLPKLID--FSAQIAEGMAFIEQ 296 Query: 175 FGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY---YRAPELI-FG 230 HRD++ N+L+ + V K+ DFG A+ + +++ + APE I FG Sbjct: 297 RNYIHRDLRAANILVSA-SLVCKIADFGLAR-----------VGAKFPIKWTAPEAINFG 344 Query: 231 ATDYTSSIDVWSAGCVLAELL-LGQPIFPGDS 261 + +T DVWS G +L E++ G+ +PG S Sbjct: 345 S--FTIKSDVWSFGILLMEIVTYGRIPYPGMS 374 >5X18-A nrPDB Length = 295 Score = 48.5 bits (114), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 45/160 (28%), Positives = 74/160 (46%), Gaps = 16/160 (10%) Query: 54 VSYTDTKVIGNGSFGVVYQAKLCDSGELVAIK---KVLQDKRFKNRELQIMRKLDHCNIV 110 + Y K IG GSFGV+++ +G VAIK + + + ++ E + + L+ + Sbjct: 7 LHYKIGKKIGEGSFGVLFEGTNMINGVPVAIKFEPRKTEAPQLRD-EYKTYKILNGTPNI 65 Query: 111 RLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLA 170 Y+F G ++ LV+D + ++ + R V+ V + M L L Sbjct: 66 PYAYYFGQEG-----LHNILVIDLLGPSLEDLFDWCGRKFSVKTVVQVAVQMITLIEDL- 119 Query: 171 YIHSFGICHRDIKPQNLLL----DPDTAVLKLCDFGSAKQ 206 H+ + +RDIKP N L+ PD + L DFG AKQ Sbjct: 120 --HAHDLIYRDIKPDNFLIGRPGQPDANNIHLIDFGMAKQ 157 >4XHL-A nrPDB Length = 394 Score = 48.5 bits (114), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 45/151 (29%), Positives = 72/151 (47%), Gaps = 16/151 (10%) Query: 62 IGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNREL----QIMRKLDHCNIVRLRYFFY 117 IG+GSFG +Y SGE VAI+ L+ R ++ +L ++ R L + +F Sbjct: 15 IGSGSFGDIYHGTNLISGEEVAIR--LESIRSRHPQLDYESRVYRYLSGGVGIPFIRWFG 72 Query: 118 SSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGI 177 GE Y +V+D + ++ + + R VI + L Q+F + YIH Sbjct: 73 REGE-----YNAMVIDLLGPSLEDLFNYCHRRFSFKTVIMLAL---QMFCRIQYIHGRSF 124 Query: 178 CHRDIKPQNLLLDPDT--AVLKLCDFGSAKQ 206 HRDIKP N L+ + + + DFG +K+ Sbjct: 125 IHRDIKPDNFLMGVGRRGSTVHVIDFGLSKK 155 >5AMN-A nrPDB Length = 299 Score = 48.5 bits (114), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 51/221 (23%), Positives = 100/221 (45%), Gaps = 29/221 (13%) Query: 60 KVIGNGSFGVVYQAKLCD----SGELVAIKKVLQDK------RFKNRELQIMRKLDHCNI 109 K +G G FG V +A +G K+L++ R E ++++++H ++ Sbjct: 29 KTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHV 88 Query: 110 VRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRA-------KQTLPVIYVKLYM 162 ++L G + L L+++Y R SR ++ L + + + Sbjct: 89 IKL------YGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYPDERALTMGDLISFA 142 Query: 163 YQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY- 221 +Q+ + + Y+ + HRD+ +N+L+ + +K+ DFG ++ + + V R Sbjct: 143 WQISQGMQYLAEMKLVHRDLAARNILV-AEGRKMKISDFGLSRDVYEEDSYVKRSQGRIP 201 Query: 222 --YRAPELIFGATDYTSSIDVWSAGCVLAELL-LGQPIFPG 259 + A E +F YT+ DVWS G +L E++ LG +PG Sbjct: 202 VKWMAIESLFDHI-YTTQSDVWSFGVLLWEIVTLGGNPYPG 241 >4WUA-A nrPDB Length = 401 Score = 48.1 bits (113), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 70/298 (23%), Positives = 113/298 (37%), Gaps = 85/298 (28%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCN------- 108 Y + +G G F V+ + + VA+K V + + L +R L Sbjct: 43 YHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPNDP 102 Query: 109 ----IVRLRYFFYSSGEKKD------EVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYV 158 +V+L F SG EV + +L ++ ++ Y Q LP+ V Sbjct: 103 NREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNY----------QGLPLPCV 152 Query: 159 KLYMYQLFRSLAYIHS-FGICHRDIKPQNLLLD--------------------------- 190 K + Q+ + L Y+H+ I H DIKP+N+LL Sbjct: 153 KKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGS 212 Query: 191 -----PDTA----------------VLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIF 229 P TA +K+ D G+A + + I +R YR+ E++ Sbjct: 213 AVSTAPATAGNFLVNPLEPKNAEKLKVKIADLGNACWVHK--HFTEDIQTRQYRSLEVLI 270 Query: 230 GATDYTSSIDVWSAGCVLAELLLGQPIFPGDSG------VDQLVEIIKVLGTPTREQI 281 G + Y + D+WS C+ EL G +F SG D + II++LG R+ I Sbjct: 271 G-SGYNTPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLI 327 >5OAT-A nrPDB Length = 411 Score = 48.1 bits (113), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 52/182 (28%), Positives = 73/182 (40%), Gaps = 48/182 (26%) Query: 167 RSLAYIHSFGICHRDIKPQNLLLD---PDTAVLKLCDFG---SAKQLVRGEPNVSYICSR 220 +A++ + GI HRD+K NLLLD P++ +L + DFG + K P SY + Sbjct: 164 EGVAHMTAHGIAHRDLKSDNLLLDTSEPESPILVISDFGCCLADKTNGLSLPYTSYEMDK 223 Query: 221 ----YYRAPELI------FGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEII 270 APE+I F +Y S D+W+ G + E+ F G S Sbjct: 224 GGNTALMAPEIICQKPGTFSVLNY-SKADLWAVGAIAYEIFNCHNPFYGPS--------- 273 Query: 271 KVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAI-ALCSRLLEYTPTARL 329 R N NY E P++ P P I AL + LL+ P RL Sbjct: 274 -----------RLKNFNYKEGDLPKL----------PDEVPTVIQALVANLLKRNPNKRL 312 Query: 330 TP 331 P Sbjct: 313 DP 314 >3AOX-A nrPDB Length = 344 Score = 47.8 bits (112), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 61/230 (26%), Positives = 95/230 (41%), Gaps = 27/230 (11%) Query: 57 TDTKVIGNGSFGVVYQAKLC----DSGELVAIKKVL------QDKRFKNRELQIMRKLDH 106 T + +G+G+FG VY+ ++ D L K L QD+ E I+ K +H Sbjct: 50 TLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNH 109 Query: 107 CNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLF 166 NIVR G + ++L+ + + +R + + P L + + Sbjct: 110 QNIVR------CIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVA 163 Query: 167 RSLA----YIHSFGICHRDIKPQNLLLD-PDTA-VLKLCDFGSAKQLVRGEPNVSYICSR 220 R +A Y+ HRDI +N LL P V K+ DFG A+ + R C+ Sbjct: 164 RDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAM 223 Query: 221 Y---YRAPELIFGATDYTSSIDVWSAGCVLAELL-LGQPIFPGDSGVDQL 266 + PE F +TS D WS G +L E+ LG +P S + L Sbjct: 224 LPVKWMPPE-AFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVL 272 >6F3F-A nrPDB Length = 455 Score = 47.8 bits (112), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 56/209 (26%), Positives = 96/209 (45%), Gaps = 27/209 (12%) Query: 62 IGNGSFGVVYQAKLCDSGELVAIKKV----LQDKRFKNRELQIMRKLDHCNIVRLRYFFY 117 +G G FG V+ + VAIK + + + F +E Q+M+KL H +V+L Sbjct: 195 LGQGCFGEVWMGTW-NGTTRVAIKTLKPGTMSPEAFL-QEAQVMKKLRHEKLVQLYAVVS 252 Query: 118 SSGEKKDEVYLNL--VLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSF 175 Y+N +LD++ + Y R Q + + Q+ +AY+ Sbjct: 253 EEPIYIVTEYMNKGSLLDFLKGETGK----YLRLPQLVDM------SAQIASGMAYVERM 302 Query: 176 GICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY---YRAPE-LIFGA 231 HRD++ N+L+ + V K+ DFG A+ L+ + +++ + APE ++G Sbjct: 303 NYVHRDLRAANILVG-ENLVCKVADFGLAR-LIEDNEYTARQGAKFPIKWTAPEAALYGR 360 Query: 232 TDYTSSIDVWSAGCVLAELLL-GQPIFPG 259 +T DVWS G +L EL G+ +PG Sbjct: 361 --FTIKSDVWSFGILLTELTTKGRVPYPG 387 >2Y4I-B nrPDB Length = 319 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 57/215 (26%), Positives = 94/215 (43%), Gaps = 41/215 (19%) Query: 60 KVIGNGSFGVVYQAKLCDSGE----LVAIKKVLQD--KRFKNRELQIMRKLDHCNIVRLR 113 ++IG G FG VY + GE L+ I++ +D K FK RE+ R+ H N+V Sbjct: 39 ELIGKGRFGQVYHGRW--HGEVAIRLIDIERDNEDQLKAFK-REVMAYRQTRHENVVLF- 94 Query: 114 YFFYSSGEKKDEVYLNLVLDYVP-ETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYI 172 G +L ++ T+Y V R AK L V + ++ + + Y+ Sbjct: 95 -----MGACMSPPHLAIITSLCKGRTLYSVVRD---AKIVLDVNKTRQIAQEIVKGMGYL 146 Query: 173 HSFGICHRDIKPQNLLLDPDTAVLKLCDFG-----SAKQLVRGEPNV----SYICSRYYR 223 H+ GI H+D+K +N+ D V + DFG Q R E + ++C + Sbjct: 147 HAKGILHKDLKSKNVFYDNGKVV--ITDFGLFSISGVLQAGRREDKLRIQNGWLC---HL 201 Query: 224 APELIFGAT--------DYTSSIDVWSAGCVLAEL 250 APE+I + ++ DV++ G + EL Sbjct: 202 APEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYEL 236 >3C1X-A nrPDB Length = 373 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 56/229 (24%), Positives = 97/229 (42%), Gaps = 29/229 (12%) Query: 60 KVIGNGSFGVVYQAKLCDSG---------ELVAIKKVLQDKRFKNRELQIMRKLDHCNIV 110 +VIG G FG VY L D+ L I + + +F + IM+ H N++ Sbjct: 95 EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGI-IMKDFSHPNVL 153 Query: 111 RLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKL-YMYQLFRSL 169 L S E V L P + R++ R + P + + + Q+ + + Sbjct: 154 SLLGICLRS-EGSPLVVL-------PYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGM 205 Query: 170 AYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSY------ICSRYYR 223 ++ S HRD+ +N +LD V K+ DFG A+ + E + + + ++ Sbjct: 206 KFLASKKFVHRDLAARNCMLDEKFTV-KVADFGLARDMYDKEFDSVHNKTGAKLPVKWMA 264 Query: 224 APELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIK 271 L +T+ DVWS G +L EL+ G P +P + D V +++ Sbjct: 265 LESL--QTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQ 311 >2PL0-A nrPDB Length = 289 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 55/207 (26%), Positives = 98/207 (47%), Gaps = 23/207 (11%) Query: 62 IGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNR---ELQIMRKLDHCNIVRLRYFFYS 118 +G G FG V+ + VA+K + Q + E +M++L H +VRL Sbjct: 31 LGAGQFGEVWMG-YYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVV-- 87 Query: 119 SGEKKDEVYLNLVLDYVPE-TVYRVARHYSRAKQTLPVIYVKLYMY-QLFRSLAYIHSFG 176 ++ +Y+ + +Y+ ++ + S K T+ + L M Q+ +A+I Sbjct: 88 ---TQEPIYI--ITEYMENGSLVDFLKTPSGIKLTINKL---LDMAAQIAEGMAFIEERN 139 Query: 177 ICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY---YRAPELIFGATD 233 HRD++ N+L+ DT K+ DFG A+ L+ + +++ + APE I T Sbjct: 140 YIHRDLRAANILVS-DTLSCKIADFGLAR-LIEDNEYTAREGAKFPIKWTAPEAINYGT- 196 Query: 234 YTSSIDVWSAGCVLAELLL-GQPIFPG 259 +T DVWS G +L E++ G+ +PG Sbjct: 197 FTIKSDVWSFGILLTEIVTHGRIPYPG 223 >5U6C-A nrPDB Length = 315 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 55/224 (24%), Positives = 89/224 (39%), Gaps = 35/224 (15%) Query: 60 KVIGNGSFGVVYQAKLC--DSGELVAIKKVLQDKRFKNRELQ-------IMRKLDHCNIV 110 K++G G FG V + L D L K ++ RE++ M+ H N++ Sbjct: 42 KILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVM 101 Query: 111 RLRYF---FYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFR 167 RL S G K V L + Y Y + + +P+ + +M + Sbjct: 102 RLLGVCIEMSSQGIPKPMVILPF-MKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIAL 160 Query: 168 SLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPEL 227 + Y+ + HRD+ +N +L D V + DFG +K++ G+ YYR + Sbjct: 161 GMEYLSNRNFLHRDLAARNCMLRDDMTVC-VADFGLSKKIYSGD---------YYRQGRI 210 Query: 228 ---------IFGATD--YTSSIDVWSAGCVLAELLL-GQPIFPG 259 I D YTS DVW+ G + E+ G +PG Sbjct: 211 AKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPG 254 >1K9A-A nrPDB Length = 450 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 50/193 (25%), Positives = 85/193 (44%), Gaps = 14/193 (7%) Query: 60 KVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN--RELQIMRKLDHCNIVRLRYFFY 117 + IG G FG V G VA+K + D + E +M +L H N+V+L Sbjct: 199 QTIGKGEFGDVMLGDY--RGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIV 256 Query: 118 SSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGI 177 E+K +Y+ V +Y+ + V SR + L + + + ++ Y+ Sbjct: 257 ---EEKGGLYI--VTEYMAKGSL-VDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNF 310 Query: 178 CHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSS 237 HRD+ +N+L+ D V K+ DFG K+ + + APE + +++ Sbjct: 311 VHRDLAARNVLVSEDN-VAKVSDFGLTKEASSTQDTGKLPVK--WTAPEAL-REKKFSTK 366 Query: 238 IDVWSAGCVLAEL 250 DVWS G +L E+ Sbjct: 367 SDVWSFGILLWEI 379 >5L2Q-C nrPDB Length = 320 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 46/187 (24%), Positives = 74/187 (39%), Gaps = 28/187 (14%) Query: 144 RHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGS 203 +HY ++ L + Y + R + +H I HRD+K N++L+ T + + +F Sbjct: 141 QHYVIKEKRLSERETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCL 200 Query: 204 AKQLV-RGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSG 262 K LV G+ S Y +P+++ G D+W+ G VL +L GQ FP Sbjct: 201 GKHLVSEGDLLKDQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQ--FPFYDS 258 Query: 263 VDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLE 322 + Q + F +IKA +T R + L +LL Sbjct: 259 IPQEL-------------------------FRKIKAAEYTIPEDGRVSENTVCLIRKLLV 293 Query: 323 YTPTARL 329 P RL Sbjct: 294 LDPQQRL 300 >5WNO-A nrPDB Length = 330 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 55/215 (25%), Positives = 94/215 (43%), Gaps = 24/215 (11%) Query: 60 KVIGNGSFGVV----YQAKLCDSGELVAIKKVLQDKRFKNREL----QIMRKLDHCNIVR 111 K +G G+FG V Y K + ++ KV Q + + E+ M +L H N+++ Sbjct: 28 KKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTDQSQTDEMLEEATNMFRLRHDNLLK 87 Query: 112 LRYF-FYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLA 170 + F + G L +V Y P + + K+ L LY YQ+ + Sbjct: 88 IIGFCMHDDG-------LKIVTIYRP--LGNLQNFLKLHKENLGAREQVLYCYQIASGMQ 138 Query: 171 YIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY---YRAPEL 227 Y+ + HRD+ +N+L+ V ++ DFG +K L +++ + + A E Sbjct: 139 YLEKQRVVHRDLATRNVLVKKFNHV-EITDFGLSKILKHDADSITIKSGKVAIKWLAIE- 196 Query: 228 IFGATDYTSSIDVWSAGCVLAELL-LGQPIFPGDS 261 IF YT + DVW+ G E++ GQ + G S Sbjct: 197 IFSKHCYTHASDVWAFGVTCWEIITFGQSPYQGMS 231 >1BYG-A nrPDB Length = 278 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 50/193 (25%), Positives = 85/193 (44%), Gaps = 14/193 (7%) Query: 60 KVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN--RELQIMRKLDHCNIVRLRYFFY 117 + IG G FG V G VA+K + D + E +M +L H N+V+L Sbjct: 27 QTIGKGEFGDVMLGDY--RGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIV 84 Query: 118 SSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGI 177 E+K +Y+ V +Y+ + V SR + L + + + ++ Y+ Sbjct: 85 ---EEKGGLYI--VTEYMAKGSL-VDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNF 138 Query: 178 CHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSS 237 HRD+ +N+L+ D V K+ DFG K+ + + APE + +++ Sbjct: 139 VHRDLAARNVLVSEDN-VAKVSDFGLTKEASSTQDTGKLPVK--WTAPEAL-REKKFSTK 194 Query: 238 IDVWSAGCVLAEL 250 DVWS G +L E+ Sbjct: 195 SDVWSFGILLWEI 207 >5FM2-A nrPDB Length = 355 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 29/103 (28%), Positives = 54/103 (52%), Gaps = 6/103 (5%) Query: 161 YMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSR 220 + +Q+ + + Y+ + HRD+ +N+L+ + +K+ DFG ++ + + V R Sbjct: 196 FAWQISQGMQYLAEMKLVHRDLAARNILV-AEGRKMKISDFGLSRDVYEEDSYVKRSQGR 254 Query: 221 Y---YRAPELIFGATDYTSSIDVWSAGCVLAELL-LGQPIFPG 259 + A E +F YT+ DVWS G +L E++ LG +PG Sbjct: 255 IPVKWMAIESLFDHI-YTTQSDVWSFGVLLWEIVTLGGNPYPG 296 >5HLW-A nrPDB Length = 299 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 56/230 (24%), Positives = 96/230 (41%), Gaps = 31/230 (13%) Query: 60 KVIGNGSFGVVYQAKLCDSG---------ELVAIKKVLQDKRFKNRELQIMRKLDHCNIV 110 +VIG G FG VY L D+ L I + + +F + IM+ H N++ Sbjct: 26 EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGI-IMKDFSHPNVL 84 Query: 111 RLRYF-FYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKL-YMYQLFRS 168 L S G L +P + R++ R + P + + + Q+ + Sbjct: 85 SLLGICLRSEGSP---------LVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKG 135 Query: 169 LAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGE------PNVSYICSRYY 222 + Y+ S HRD+ +N +LD V K+ DFG A+ + E + + ++ Sbjct: 136 MKYLASKKFVHRDLAARNCMLDEKFTV-KVADFGLARDMHDKEYYSVHNKTGAKLPVKWM 194 Query: 223 RAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIK 271 L +T+ DVWS G +L EL+ G P +P + D V +++ Sbjct: 195 ALESL--QTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQ 242 >2QKW-B nrPDB Length = 321 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 53/205 (25%), Positives = 88/205 (42%), Gaps = 29/205 (14%) Query: 61 VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG 120 +IG+G FG VY+ L D ++ ++ + + + L C L Sbjct: 46 LIGHGVFGKVYKGVLRDGAKVALKRRTPESSQGIEEFETEIETLSFCRHPHLVSLIGFCD 105 Query: 121 EKKDEVYLNLVLDYVPETVYRVARH-YSRAKQTLPVIYVKLYMYQL--FRSLAYIHSFGI 177 E+ + + L+ Y+ + RH Y T+ + + + + R L Y+H+ I Sbjct: 106 ERNEMI---LIYKYMENG--NLKRHLYGSDLPTMSMSWEQRLEICIGAARGLHYLHTRAI 160 Query: 178 CHRDIKPQNLLLDPDTAVLKLCDFGSAKQ-----------LVRGEPNVSYICSRYYRAPE 226 HRD+K N+LLD + V K+ DFG +K+ +V+G + YI Y+ Sbjct: 161 IHRDVKSINILLD-ENFVPKITDFGISKKGTELDQTHLSTVVKG--TLGYIDPEYFIKGR 217 Query: 227 LIFGATDYTSSIDVWSAGCVLAELL 251 L T DV+S G VL E+L Sbjct: 218 L-------TEKSDVYSFGVVLFEVL 235 >5X1R-A nrPDB Length = 302 Score = 45.8 bits (107), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 52/238 (21%), Positives = 96/238 (40%), Gaps = 65/238 (27%) Query: 60 KVIGNGSFGVVYQAKLCDSGELVAIKKV---------------LQDKRFKN--------- 95 + IG G FG+VY+A +AIK+ L+ +RF Sbjct: 27 EAIGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAKRNDDLSIGLRGERFGKTFQAGLNSF 86 Query: 96 -RELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYS------- 147 +E +++ + H ++ + F+ +G T Y + YS Sbjct: 87 IQEARLLARFSHPGLLHVLRFWEENG-----------------TAYMGTQFYSGTTLKNL 129 Query: 148 RAKQ--TLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAK 205 +A+Q + +++ + LF ++ IH G HRDI N+ + ++ + L DFGSA+ Sbjct: 130 QAQQPEKIDEAWIRRLLPPLFSAINTIHQEGYLHRDISLDNIQIQ-ESQLPVLLDFGSAR 188 Query: 206 QLVRGEPNVSYICSRYYRAPELIFGATDYTSS--------IDVWSAGCVLAELLLGQP 255 + + + + I + AP YT + D+++ G VL L++G P Sbjct: 189 KEIGNLSDETEIVLKPGFAP-----IEQYTENSDGEQGPWTDIYALGAVLHTLIVGSP 241 >4M66-A nrPDB Length = 325 Score = 45.8 bits (107), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 59/211 (27%), Positives = 95/211 (45%), Gaps = 33/211 (15%) Query: 62 IGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGE 121 +G G FGVV++A VA+K ++ K+ + E++ M L + N++ L G Sbjct: 28 VGKGGFGVVFRAHHRTWNHDVAVK-IVNSKKI-SWEVKAMVNLRNENVLLLL------GV 79 Query: 122 KKDEVYLNLVLDYVP--ETVYRVARHYSRAKQTLPV------IYVKLYMYQLFRSLAYIH 173 +D L D+V V R + S A P + +L + ++ + Y+H Sbjct: 80 TED-----LQWDFVSGQALVTRFMENGSLAGLLQPEAPRPWPLLCRL-LQEVVLGMCYLH 133 Query: 174 SFG--ICHRDIKPQNLLLDPDTAVLKLCDFG-------SAKQLVRGEPNVSYICSRYYRA 224 S + HRD+KP N+LLDP+ KL DFG S G + + Y Sbjct: 134 SLDPPLLHRDLKPSNILLDPELHA-KLADFGLSTFQGGSQSGSGSGSGSRDSGGTLAYLD 192 Query: 225 PELIFGATDYTS-SIDVWSAGCVLAELLLGQ 254 PEL+F S + DV+S G ++ +L G+ Sbjct: 193 PELLFKVNLKASKASDVYSFGILVWAVLAGR 223 >6G4J-A nrPDB Length = 315 Score = 45.4 bits (106), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 45/202 (22%), Positives = 81/202 (40%), Gaps = 27/202 (13%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRY 114 +YT K +G G+ G+VY A+ D VA+K V D E+ +++ V + Sbjct: 27 TYTLRKQLGKGANGIVYLAETSDGH--VALK-VSDDSLSITSEVNVLKSFSKAQSVTMGP 83 Query: 115 FFYSSGEKKDEVYLNLVLDYVPETVYRV---ARHYSRAKQTLPVI------YVKLYMYQL 165 F+ + + Y+P +V A Y + L + ++ + M QL Sbjct: 84 SFFDTDDA-----------YIPSANTKVSFYAMEYIKGPLLLKYVSDKGAEWIPVLMIQL 132 Query: 166 FRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAP 225 SL+ +H G D+KP NL++ A ++ D G + R + R Y Sbjct: 133 LSSLSVLHQQGWIFGDLKPDNLIVTGPPARIRCIDVGGTTKEGRAIKEYTEFYDRGYWG- 191 Query: 226 ELIFGATDYTSSIDVWSAGCVL 247 +G S D+++ ++ Sbjct: 192 ---YGTRKAEPSYDLFAVAMIM 210 >5SYS-A nrPDB Length = 286 Score = 45.1 bits (105), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 56/214 (26%), Positives = 100/214 (46%), Gaps = 37/214 (17%) Query: 62 IGNGSFGVVYQAKLCDSGELVAIKKV----LQDKRFKNRELQIMRKLDHCNIVRLRYFFY 117 +G G FG + + VAIK + + + F +E Q+M+KL H +V+L Y Sbjct: 26 LGQGCFGECWMGTW-NGTTRVAIKTLKPGTMSPEAFL-QEAQVMKKLRHEKLVQL-YAVV 82 Query: 118 SSGEKKDEVYL-------NLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLA 170 S ++ +Y+ +LD++ + + Y R Q + + Q+ +A Sbjct: 83 S----EEPIYIVTEYMSKGSLLDFLKGEMGK----YLRLPQLVDMAA------QIASGMA 128 Query: 171 YIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY---YRAPE- 226 Y+ HRD++ N+L+ + V K+ DFG A+ L+ + +++ + APE Sbjct: 129 YVERMNYVHRDLRAANILVG-ENLVCKVADFGLAR-LIEDNEYTARQGAKFPIKWTAPEA 186 Query: 227 LIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPG 259 ++G +T DVWS G +L EL G+ +PG Sbjct: 187 ALYG--RFTIKSDVWSFGILLTELTTKGRVPYPG 218 >3QUP-A nrPDB Length = 323 Score = 45.1 bits (105), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 52/223 (23%), Positives = 97/223 (43%), Gaps = 18/223 (8%) Query: 53 EVSYTDTKVIGNGSFGVVYQAKL-CDSGELVAIK-KVLQDKRFKN-------RELQIMRK 103 E +T +++G G FG V +A+L + G V + K+L+ + RE M++ Sbjct: 22 EQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKE 81 Query: 104 LDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPET---VYRVARHYSRAKQTLPVIYVKL 160 DH ++ +L S K ++L ++ + +A LP+ + Sbjct: 82 FDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLVR 141 Query: 161 YMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSR 220 +M + + Y+ S HRD+ +N +L D V + DFG ++++ G+ S+ Sbjct: 142 FMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVC-VADFGLSRKIYSGDYYRQGCASK 200 Query: 221 Y---YRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPG 259 + A E + YT DVW+ G + E++ GQ + G Sbjct: 201 LPVKWLALESL-ADNLYTVHSDVWAFGVTMWEIMTRGQTPYAG 242 >4TN6-A nrPDB Length = 318 Score = 44.7 bits (104), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 47/158 (29%), Positives = 74/158 (46%), Gaps = 18/158 (11%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKL-----DHCNIV 110 Y + IG+GSFG +Y +GE VAIK L+ + K+ +L I K+ I Sbjct: 9 YRLGRKIGSGSFGDIYLGTDIAAGEEVAIK--LECVKTKHPQLHIESKIYKMMQGGVGIP 66 Query: 111 RLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLA 170 +R+ G + D Y +V++ + ++ + SR V+ L Q+ + Sbjct: 67 TIRW----CGAEGD--YNVMVMELLGPSLEDLFNFCSRKFSLKTVL---LLADQMISRIE 117 Query: 171 YIHSFGICHRDIKPQNLL--LDPDTAVLKLCDFGSAKQ 206 YIHS HRD+KP N L L ++ + DFG AK+ Sbjct: 118 YIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKK 155 >5VC6-A nrPDB Length = 289 Score = 44.7 bits (104), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 38/148 (25%), Positives = 70/148 (47%), Gaps = 26/148 (17%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ------DKRFKNRELQIMRKL-DHCN 108 + + + IG+G FG V++ G + AIK+ + D++ RE+ L H + Sbjct: 13 FHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSH 72 Query: 109 IVRLRYFFYSSGEKKDEVYL-------NLVLDYVPETVYRVARHYSRAKQTLPVIYVKLY 161 +VR ++S+ + D + + + D + E YR+ ++ A+ +K Sbjct: 73 VVR----YFSAWAEDDHMLIQNEYCNGGSLADAISEN-YRIMSYFKEAE-------LKDL 120 Query: 162 MYQLFRSLAYIHSFGICHRDIKPQNLLL 189 + Q+ R L YIHS + H DIKP N+ + Sbjct: 121 LLQVGRGLRYIHSMSLVHMDIKPSNIFI 148 >1LUF-A nrPDB Length = 343 Score = 44.7 bits (104), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 58/231 (25%), Positives = 93/231 (40%), Gaps = 56/231 (24%) Query: 62 IGNGSFGVVYQAKL-----CDSGELVAIKKVLQDKRFK-----NRELQIMRKLDHCNIVR 111 IG G+FG V+QA+ + +VA+K + ++ RE +M + D+ NIV+ Sbjct: 55 IGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVK 114 Query: 112 LR-----------YFFYSSGEKKDEVYLNLVLDYVPETVYRV--------ARHYSRAKQT 152 L F Y + +E ++ P TV + AR S Sbjct: 115 LLGVCAVGKPMCLLFEYMAYGDLNEFLRSMS----PHTVCSLSHSDLSTRARVSSPGPPP 170 Query: 153 LPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEP 212 L Q+ +AY+ HRD+ +N L+ + V+K+ DFG ++ + + Sbjct: 171 LSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVG-ENMVVKIADFGLSRNIYSAD- 228 Query: 213 NVSYICSRYYRA------------PELIFGATDYTSSIDVWSAGCVLAELL 251 YY+A PE IF YT+ DVW+ G VL E+ Sbjct: 229 --------YYKADGNDAIPIRWMPPESIF-YNRYTTESDVWAYGVVLWEIF 270 >4XLV-A nrPDB Length = 328 Score = 44.7 bits (104), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 51/205 (24%), Positives = 91/205 (44%), Gaps = 20/205 (9%) Query: 62 IGNGSFGVVYQAKLCD--SGEL---VAIKKVLQDKRFKNR-----ELQIMRKLDHCNIVR 111 +G GSFG+VY+ D GE VA+K V + + R E +M+ ++VR Sbjct: 47 LGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVR 106 Query: 112 LRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAK--QTLPVIYVKLYMY-QLFRS 168 L S + V + L+ ++ R R + + P + + M ++ Sbjct: 107 L--LGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADG 164 Query: 169 LAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGE---PNVSYICSRYYRAP 225 +AY+++ HRD+ +N ++ D V K+ DFG + + + + + AP Sbjct: 165 MAYLNAKKFVHRDLAARNCMVAHDFTV-KIGDFGMTRDIYETDYYRKGGKGLLPVRWMAP 223 Query: 226 ELIFGATDYTSSIDVWSAGCVLAEL 250 E + +T+S D+WS G VL E+ Sbjct: 224 ESLKDGV-FTTSSDMWSFGVVLWEI 247 >4XHH-A nrPDB Length = 403 Score = 44.7 bits (104), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 43/151 (28%), Positives = 71/151 (47%), Gaps = 16/151 (10%) Query: 62 IGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNREL----QIMRKLDHCNIVRLRYFFY 117 IG+GSFG +Y SGE VAI+ L+ R ++ +L ++ + L + +F Sbjct: 15 IGSGSFGDIYHGTNLISGEEVAIR--LESIRSRHPQLDYESRVYKYLSGGVGIPFIRWFG 72 Query: 118 SSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGI 177 GE Y +V+D + ++ + + R VI + L Q+ + YIH Sbjct: 73 REGE-----YNAMVIDLLGPSLEDLFNYCHRKFSFKTVIMLAL---QMICRVQYIHGRSF 124 Query: 178 CHRDIKPQNLLLDPDT--AVLKLCDFGSAKQ 206 HRDIKP N L+ + + + DFG +K+ Sbjct: 125 IHRDIKPDNFLMGVGRRGSTVHVIDFGLSKK 155 >2CMW-A nrPDB Length = 310 Score = 44.7 bits (104), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 45/165 (27%), Positives = 75/165 (45%), Gaps = 33/165 (20%) Query: 60 KVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFY-- 117 K IG G+FG + K + E VAIK + K+R Q+ L Y FY Sbjct: 6 KKIGCGNFGELRLGKNLYTNEYVAIKL----EPIKSRAPQL----------HLEYRFYKQ 51 Query: 118 --SSGEKKDEVYL--------NLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFR 167 S+GE +VY +VL+ + ++ + + +T + V + QL Sbjct: 52 LGSAGEGLPQVYYFGPCGKYNAMVLELLGPSLEDL---FDLCDRTFTLKTVLMIAIQLLS 108 Query: 168 SLAYIHSFGICHRDIKPQNLLL----DPDTAVLKLCDFGSAKQLV 208 + Y+HS + +RD+KP+N L+ + V+ + DFG AK+ + Sbjct: 109 RMEYVHSKNLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYI 153 >5UV4-A nrPDB Length = 311 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 61/251 (24%), Positives = 116/251 (46%), Gaps = 40/251 (15%) Query: 52 QEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKV----LQDKRFKNRELQIMRKLDHC 107 +E+S ++IG G Y+A L D+G ++ +K + + K+ +RE++ + + H Sbjct: 23 EELSCAPAEIIGRSCHGTSYKATL-DNGYMLTVKWLKEGFAKSKKEFSREIKKLGSVRHP 81 Query: 108 NIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSR-AKQTLPVIYVKLYM---Y 163 N+V LR +++ G K+ E ++ DY T ++ + S ++ LP + + Sbjct: 82 NLVPLRGYYW--GPKEHERI--MISDYADAT--SLSTYLSEFDERNLPPLSAGQRLNIAI 135 Query: 164 QLFRSLAYIHSFGIC-HRDIKPQNLLLDPDTAVLKLCDF---------GSAKQLVRGEPN 213 + R L Y+H+ + H +IK N+L+ T + D+ G A+Q++ Sbjct: 136 DIARCLDYLHNERVIPHGNIKSSNVLIQNSTPSALVTDYSLHRLMTPIGMAEQVLNAG-- 193 Query: 214 VSYICSRYYRAPELIFGATDY---TSSIDVWSAGCVLAELLLGQ---PIFPGDSGVDQLV 267 + Y PE F +T + DV++ G +L ELL G+ I + GV L Sbjct: 194 -----ALGYSPPE--FSSTSKPCPSLKSDVYAFGVILLELLTGKIAGEIICMNDGVVDLT 246 Query: 268 EIIKVLGTPTR 278 + +++L R Sbjct: 247 DWVRMLDLEER 257 >5E8V-A nrPDB Length = 316 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 56/216 (25%), Positives = 91/216 (42%), Gaps = 33/216 (15%) Query: 61 VIGNGSFGVVYQAKL----CDSGELVAIKKV-LQDKRFKNRELQIMR--KLDHCNIVRLR 113 ++G G F VY+AKL + E VA+K ++ E I L H NI++ Sbjct: 16 LVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQ-- 73 Query: 114 YFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIH 173 F ++ E+K E+ L + + +R + ++ L R +A++H Sbjct: 74 --FLTAEERKTELGKQYWLITAFHAKGNLQEYLTR--HVISWEDLRKLGSSLARGIAHLH 129 Query: 174 S---------FGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQL-----VRGEPNVSYICS 219 S I HRD+K N+L+ D LCDFG + +L V N + + Sbjct: 130 SDHTPCGRPKMPIVHRDLKSSNILVKNDLTCC-LCDFGLSLRLDPTLSVDDLANSGQVGT 188 Query: 220 RYYRAPELIFGATDYTS-----SIDVWSAGCVLAEL 250 Y APE++ A + + DV+S VL E+ Sbjct: 189 ARYMAPEVLASAMNLENVESFKQTDVYSMALVLWEM 224 >3PP0-A nrPDB Length = 338 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 57/223 (25%), Positives = 93/223 (41%), Gaps = 24/223 (10%) Query: 42 ATPGQGPDRP-QEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIK---KVLQDKRF--KN 95 A P Q R +E KV+G+G+FG VY+ GE V I KVL++ N Sbjct: 4 AAPNQALLRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKAN 63 Query: 96 REL----QIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQ 151 +E+ +M + + RL +S + LV +P + H + Sbjct: 64 KEILDEAYVMAGVGSPYVSRLLGICLTS-------TVQLVTQLMPYGC--LLDHVRENRG 114 Query: 152 TLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGE 211 L + + Q+ + ++Y+ + HRD+ +N+L+ V K+ DFG A+ L E Sbjct: 115 RLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHV-KITDFGLARLLDIDE 173 Query: 212 PNVSYICSRY---YRAPELIFGATDYTSSIDVWSAGCVLAELL 251 + + A E I +T DVWS G + EL+ Sbjct: 174 TEYHADGGKVPIKWMALESIL-RRRFTHQSDVWSYGVTVWELM 215 >3BYV-A nrPDB Length = 377 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 41/156 (26%), Positives = 69/156 (44%), Gaps = 27/156 (17%) Query: 103 KLDHCNIVRL-RYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLY 161 +LD ++ L R+F Y + + + ++L + + ++ H++R + TL VI Sbjct: 164 RLDERDMWVLSRFFLYPRMQSNLQTFGEVLLSH--SSTHKSLVHHARLQLTLQVI----- 216 Query: 162 MYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY 221 R LA +H +G+ H ++P +++LD V L F + LVR V SR Sbjct: 217 -----RLLASLHHYGLVHTYLRPVDIVLDQRGGVF-LTGF---EHLVRDGARVVSSVSRG 267 Query: 222 YRAPELIF----------GATDYTSSIDVWSAGCVL 247 + PEL T T S D W+ G V+ Sbjct: 268 FEPPELEARRATISYHRDRRTLMTFSFDAWALGLVI 303 >5CLR-A nrPDB Length = 451 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 30/88 (34%), Positives = 43/88 (48%), Gaps = 10/88 (11%) Query: 147 SRAKQTLPV-IYVKLY------MYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLC 199 SR K LP+ + +K + M + + H G+ HRD+KP N++LD D L Sbjct: 160 SRYKNALPLNVNLKHFWEVLGIMISVCHQVKQFHELGLIHRDLKPGNIMLDADMQC-HLV 218 Query: 200 DFGSAKQLVRGEPNVSYICSRYYRAPEL 227 DFGS+ EP + + Y APEL Sbjct: 219 DFGSSSS--DKEPKPASWGTASYLAPEL 244 >5AR8-A nrPDB Length = 326 Score = 42.7 bits (99), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 43/160 (26%), Positives = 71/160 (44%), Gaps = 22/160 (13%) Query: 58 DTKVIGNGSFGVVYQAKLCDSGELVAIKKV-----LQDKRFKN--RELQIMRKLDHCNIV 110 D + + G+ G V A+ D VA+K + L D K+ RE +I+ K Sbjct: 36 DLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHK------A 89 Query: 111 RLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKL---YMYQLFR 167 R Y G + +L +V +Y+P H K P + L ++++ Sbjct: 90 RFSYILPILGICNEPEFLGIVTEYMPNGSLNELLH---RKTEYPDVAWPLRFRILHEIAL 146 Query: 168 SLAYIHSFG--ICHRDIKPQNLLLDPDTAVLKLCDFGSAK 205 + Y+H+ + H D+K QN+LLD + V K+ DFG +K Sbjct: 147 GVNYLHNMTPPLLHHDLKTQNILLDNEFHV-KIADFGLSK 185 >3DZO-A nrPDB Length = 413 Score = 42.0 bits (97), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 40/158 (25%), Positives = 70/158 (44%), Gaps = 26/158 (16%) Query: 100 IMRKLDHCNIVRL-RYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYV 158 I +LD ++ L R+F Y + + + ++L + + ++ H++R + TL VI Sbjct: 166 IRVRLDERDMWVLSRFFLYPRMQSNLQTFGEVLLSH--SSTHKSLVHHARLQLTLQVI-- 221 Query: 159 KLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYIC 218 R LA +H +G+ H ++P +++LD V L F + LVR + Sbjct: 222 --------RLLASLHHYGLVHTYLRPVDIVLDQRGGVF-LTGF---EHLVRDGASAVSPI 269 Query: 219 SRYYRAPE------LIFGA---TDYTSSIDVWSAGCVL 247 R + PE L FG T T + D W+ G + Sbjct: 270 GRGFAPPETTAERMLPFGQHHPTLMTFAFDTWTLGLAI 307 >2CHL-A nrPDB Length = 351 Score = 41.6 bits (96), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 39/155 (25%), Positives = 71/155 (45%), Gaps = 14/155 (9%) Query: 60 KVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQ--IMRKLDHCNIVRLRYFFY 117 K IG G+FG + K + E VAIK R L+ ++L + + Y+F Sbjct: 36 KKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGIPQVYYFG 95 Query: 118 SSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGI 177 G+ Y +VL+ + ++ + + +T + V + QL + Y+HS + Sbjct: 96 PCGK-----YNAMVLELLGPSLEDL---FDLCDRTFSLKTVLMIAIQLISRMEYVHSKNL 147 Query: 178 CHRDIKPQNLLL----DPDTAVLKLCDFGSAKQLV 208 +RD+KP+N L+ + V+ + DF AK+ + Sbjct: 148 IYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYI 182 >3I81-A nrPDB Length = 315 Score = 41.6 bits (96), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 56/219 (25%), Positives = 95/219 (43%), Gaps = 38/219 (17%) Query: 57 TDTKVIGNGSFGVVYQ--AKLCDSGE---LVAIKKVLQDKRFKNR-----ELQIMRKLDH 106 T ++ +G GSFG+VY+ AK E VAIK V + + R E +M++ + Sbjct: 21 TMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNC 80 Query: 107 CNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTL--PVIYVKLYMY- 163 ++VRL S + V + L+ ++ R R L P + + M Sbjct: 81 HHVVRL--LGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMAG 138 Query: 164 QLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYR 223 ++ +AY+++ HRD+ +N ++ D V K+ DFG + + + YYR Sbjct: 139 EIADGMAYLNANKFVHRDLAARNCMVAEDFTV-KIGDFGMTRDIYE---------TDYYR 188 Query: 224 ------------APELIFGATDYTSSIDVWSAGCVLAEL 250 +PE + +T+ DVWS G VL E+ Sbjct: 189 KGGKGLLPVRWMSPESLKDGV-FTTYSDVWSFGVVLWEI 226 >2C47-A nrPDB Length = 313 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 41/155 (26%), Positives = 71/155 (45%), Gaps = 14/155 (9%) Query: 60 KVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQ--IMRKLDHCNIVRLRYFFY 117 K IG G+FG + K + E VAIK R L+ ++L V Y+F Sbjct: 10 KKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLSATEGVPQVYYFG 69 Query: 118 SSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGI 177 G+ Y +VL+ + ++ + + +T + V + QL + Y+H+ + Sbjct: 70 PCGK-----YNAMVLELLGPSLEDL---FDLCDRTFTLKTVLMIAIQLITRMEYVHTKSL 121 Query: 178 CHRDIKPQNLLLD-PDTA---VLKLCDFGSAKQLV 208 +RD+KP+N L+ P T + + DFG AK+ + Sbjct: 122 IYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYI 156 >6BFN-A nrPDB Length = 342 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 52/221 (23%), Positives = 97/221 (43%), Gaps = 31/221 (14%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQD--------KRFKNRELQIMRKLDH 106 ++++ IG G FG VY+A + ++ + A+K++ ++ K+ E++ + + H Sbjct: 23 NFSEELKIGEGGFGCVYRAVMRNT--VYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRH 80 Query: 107 CNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLY--MYQ 164 NIV + +G + LV ++P R + + + P+ + + + Sbjct: 81 PNIVDFAGYCAQNG------FYCLVYGFLPNGSLE-DRLHCQTQACPPLSWPQRLDILLG 133 Query: 165 LFRSLAYIH--SFGICHRDIKPQNLLLDPDTAVLKLCDFGSAK--QLVRGEPNVSYICSR 220 R++ ++H S + H DIK N+LLD + KL DFG A+ + P+ S + +R Sbjct: 134 TARAIQFLHQDSPSLIHGDIKSSNVLLD-ERLTPKLGDFGLARFSRFAGSSPSQSSMVAR 192 Query: 221 YYRA-------PELIFGATDYTSSIDVWSAGCVLAELLLGQ 254 PE D +S G V+ E L GQ Sbjct: 193 TQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQ 233 >5WNL-A nrPDB Length = 342 Score = 39.3 bits (90), Expect = 0.003, Method: Compositional matrix adjust. Identities = 40/156 (25%), Positives = 73/156 (46%), Gaps = 15/156 (9%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIK---KVLQDKRFKNRELQIMRKLDHCNIVR 111 + + +G+G FG VY+ + +AIK + D R + L+ +K++ + + Sbjct: 21 EFAGWEKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERMELLEEAKKME---MAK 77 Query: 112 LRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAY 171 RY G ++ V LV++Y+ ET + A + LP +++ + + Sbjct: 78 FRYILPVYGICQEPV--GLVMEYM-ETG---SLEKLLASEPLPWDLRFRIVHETAVGMNF 131 Query: 172 IHSFG--ICHRDIKPQNLLLDPDTAVLKLCDFGSAK 205 +H + H ++KP N+LLD V K+ DFG AK Sbjct: 132 LHCMSPPLLHLNLKPANILLDAHYHV-KISDFGLAK 166 >4NT4-A nrPDB Length = 312 Score = 38.9 bits (89), Expect = 0.004, Method: Compositional matrix adjust. Identities = 17/54 (31%), Positives = 31/54 (57%), Gaps = 4/54 (7%) Query: 164 QLFRSLAYIHSFGICHRDIKPQNLLLDPDTA----VLKLCDFGSAKQLVRGEPN 213 QL + Y+HS + +RD+KP+N L+ + ++ + DFG AK+ + + N Sbjct: 122 QLLHRIEYVHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTN 175 >3Q4U-A nrPDB Length = 301 Score = 38.5 bits (88), Expect = 0.006, Method: Compositional matrix adjust. Identities = 53/215 (24%), Positives = 87/215 (40%), Gaps = 36/215 (16%) Query: 60 KVIGNGSFGVVYQAKLCDSGELVAIKKVL---QDKRFKNRELQIMRKLDHCNIVRLRYFF 116 + +G G +G V++ GE VA+K + F+ EL L H NI L + Sbjct: 14 ECVGKGRYGEVWRGSW--QGENVAVKIFSSRDEKSWFRETELYNTVMLRHENI--LGFIA 69 Query: 117 YSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAK-QTLPVIYVKLYMYQLFRSLAYIHS- 174 + L L+ Y + + Y + TL + + + LA++H Sbjct: 70 SDMTSRHSSTQLWLITHY-----HEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIE 124 Query: 175 -FG------ICHRDIKPQNLLLDPDTAVLKLCDFG-------SAKQLVRGEPNVSYICSR 220 FG I HRD+K +N+L+ + + D G S QL G N + ++ Sbjct: 125 IFGTQGKPAIAHRDLKSKNILVKKNGQCC-IADLGLAVMHSQSTNQLDVG--NNPRVGTK 181 Query: 221 YYRAPELI-----FGATDYTSSIDVWSAGCVLAEL 250 Y APE++ D +D+W+ G VL E+ Sbjct: 182 RYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEV 216 >1CSN-A nrPDB Length = 298 Score = 38.1 bits (87), Expect = 0.007, Method: Compositional matrix adjust. Identities = 40/160 (25%), Positives = 69/160 (43%), Gaps = 18/160 (11%) Query: 54 VSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFK----NRELQIMRKLDHCNI 109 V Y + IG GSFGV+++ + + VAIK + +R E + + L C Sbjct: 10 VHYKVGRRIGEGSFGVIFEGTNLLNNQQVAIK--FEPRRSDAPQLRDEYRTYKLLAGCTG 67 Query: 110 VRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 169 + Y+F G ++ LV+D + ++ + R V V + Q+ + Sbjct: 68 IPNVYYFGQEG-----LHNVLVIDLLGPSLEDLLDLCGR---KFSVKTVAMAAKQMLARV 119 Query: 170 AYIHSFGICHRDIKPQNLLL----DPDTAVLKLCDFGSAK 205 IH + +RDIKP N L+ + ++ + DFG K Sbjct: 120 QSIHEKSLVYRDIKPDNFLIGRPNSKNANMIYVVDFGMVK 159 >4CI6-B nrPDB Length = 643 Score = 37.0 bits (84), Expect = 0.015, Method: Compositional matrix adjust. Identities = 36/141 (25%), Positives = 61/141 (43%), Gaps = 14/141 (9%) Query: 127 YLNLVLDYV-----PETVYRVARHYSRAKQTLPVIY--VKLYMYQLFRSLAYIHSFGICH 179 Y L++D V +T+ +A + + K + +K ++L ++ GI H Sbjct: 120 YYALLMDEVDGWRCSDTLRSLADSWKQGKINSEAYWGTIKFIAHRLLDVTNHLAKAGIVH 179 Query: 180 RDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSID 239 DIKP N++ D + + D G + GE + S ++APEL G + D Sbjct: 180 NDIKPGNVVFDRASGEPVVIDLGLHSR--SGEQPKGFTES--FKAPELGVGNLGASEKSD 235 Query: 240 VWSAGCVLAELLLGQPIFPGD 260 V+ V++ LL G F D Sbjct: 236 VF---LVVSTLLHGIEGFEKD 253 >1PY5-A nrPDB Length = 326 Score = 37.0 bits (84), Expect = 0.017, Method: Compositional matrix adjust. Identities = 60/241 (24%), Positives = 103/241 (42%), Gaps = 44/241 (18%) Query: 41 VATPGQGPDRPQEVSYTDTKVI------GNGSFGVVYQAKLCDSGELVAIKKVL-QDKRF 93 + T G G P V T + I G G FG V++ K GE VA+K +++R Sbjct: 10 MTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKW--RGEEVAVKIFSSREERS 67 Query: 94 KNRELQIMRK--LDHCNIVRLRYFFYSSGEKKDEVY--LNLVLDYVPE-TVYRVARHYSR 148 RE +I + L H NI+ F ++ K + + L LV DY +++ Y+ Sbjct: 68 WFREAEIYQTVMLRHENILG----FIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTV 123 Query: 149 AKQTLPVIYVKLYMYQLFRSLAYIHSF--------GICHRDIKPQNLLLDPDTAVLKLCD 200 + + +KL + LA++H I HRD+K +N+L+ + + D Sbjct: 124 TVEGM----IKLAL-STASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCC-IAD 177 Query: 201 FG------SAKQLVRGEPNVSYICSRYYRAPELIFGATDYT-----SSIDVWSAGCVLAE 249 G SA + PN + ++ Y APE++ + + D+++ G V E Sbjct: 178 LGLAVRHDSATDTIDIAPN-HRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWE 236 Query: 250 L 250 + Sbjct: 237 I 237 >5C01-A nrPDB Length = 342 Score = 37.0 bits (84), Expect = 0.018, Method: Compositional matrix adjust. Identities = 27/110 (24%), Positives = 52/110 (47%), Gaps = 10/110 (9%) Query: 148 RAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLL------DPDTAVLKLCDF 201 R + +P+ + + QL +L+Y+ + + H ++ +N+LL + + +KL D Sbjct: 172 RERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDP 231 Query: 202 GSAKQLVRGEPNVSYICSRYYRAPELI-FGATDYTSSIDVWSAGCVLAEL 250 G + E V I + APE + GA ++++D W G L E+ Sbjct: 232 GVGLGALSREERVERIP---WLAPECLPGGANSLSTAMDKWGFGATLLEI 278 >4WOV-A nrPDB Length = 317 Score = 36.6 bits (83), Expect = 0.020, Method: Compositional matrix adjust. Identities = 27/110 (24%), Positives = 52/110 (47%), Gaps = 10/110 (9%) Query: 148 RAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLL------DPDTAVLKLCDF 201 R + +P+ + + QL +L+Y+ + + H ++ +N+LL + + +KL D Sbjct: 149 RERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDP 208 Query: 202 GSAKQLVRGEPNVSYICSRYYRAPELI-FGATDYTSSIDVWSAGCVLAEL 250 G + E V I + APE + GA ++++D W G L E+ Sbjct: 209 GVGLGALSREERVERIP---WLAPECLPGGANSLSTAMDKWGFGATLLEI 255 >4O1O-A nrPDB Length = 717 Score = 36.2 bits (82), Expect = 0.025, Method: Compositional matrix adjust. Identities = 14/37 (37%), Positives = 23/37 (62%), Gaps = 1/37 (2%) Query: 165 LFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDF 201 LF+++ +H G H+D++PQN+L+D L DF Sbjct: 451 LFKAIGELHRSGYSHQDLQPQNILIDSKNGTF-LADF 486 >5VDK-A nrPDB Length = 297 Score = 35.8 bits (81), Expect = 0.032, Method: Compositional matrix adjust. Identities = 37/150 (24%), Positives = 63/150 (42%), Gaps = 24/150 (16%) Query: 53 EVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKL-------D 105 E + + + IG G FG VY+ G + AIK+ ++ + E + ++ Sbjct: 14 EKEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSALHEVYAHAVLGH 73 Query: 106 HCNIVRLRYFFYSSGEKKDEV-----YLNL-VLDYVPETVYRVARHYSRAKQTLPVIYVK 159 H ++VR +YSS + D + Y N L + H+ K +K Sbjct: 74 HPHVVR----YYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPK-------LK 122 Query: 160 LYMYQLFRSLAYIHSFGICHRDIKPQNLLL 189 + Q+ L YIH+ + H DIKP N+ + Sbjct: 123 DILLQISLGLNYIHNSSMVHLDIKPSNIFI 152 >4AZV-A nrPDB Length = 569 Score = 34.7 bits (78), Expect = 0.075, Method: Compositional matrix adjust. Identities = 16/39 (41%), Positives = 23/39 (58%), Gaps = 1/39 (2%) Query: 165 LFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGS 203 L RSLA + G H D++P N+++D +L DFGS Sbjct: 348 LLRSLAALEKQGFWHDDVRPWNVMVDARQHA-RLIDFGS 385 >2RSV-A nrPDB Length = 403 Score = 34.7 bits (78), Expect = 0.078, Method: Compositional matrix adjust. Identities = 45/173 (26%), Positives = 72/173 (41%), Gaps = 44/173 (25%) Query: 62 IGNGSFGVVYQAKL------------------CDSGELVAIKKVLQDKRFKNRELQIM-- 101 IG G FG +Y A + D+G L K Q + K ++Q Sbjct: 50 IGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQ-RAAKPEQIQKWIR 108 Query: 102 -RKLDHCNIVRLRYFFYSSG--EKKDEVYLNLVLDYVPETVYRV----ARHYSRAKQTLP 154 RKL + + + ++ SG +K + Y +++D + ++ A+ +SR Sbjct: 109 TRKLKYLGVPK----YWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRK----T 160 Query: 155 VIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLL---DPDTAVLKLCDFGSA 204 V+ + L + + L YIH H DIK NLLL +PD L D+G A Sbjct: 161 VLQLSLRILDI---LEYIHEHEYVHGDIKASNLLLNYKNPDQVY--LVDYGLA 208 >4AZW-A nrPDB Length = 471 Score = 33.9 bits (76), Expect = 0.12, Method: Compositional matrix adjust. Identities = 16/39 (41%), Positives = 23/39 (58%), Gaps = 1/39 (2%) Query: 165 LFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGS 203 L RSLA + G H D++P N+++D +L DFGS Sbjct: 348 LLRSLAALEKKGFWHDDVRPWNVMVDARQHA-RLIDFGS 385 >2LAV-A nrPDB Length = 361 Score = 33.9 bits (76), Expect = 0.15, Method: Compositional matrix adjust. Identities = 45/173 (26%), Positives = 72/173 (41%), Gaps = 44/173 (25%) Query: 62 IGNGSFGVVYQAKL------------------CDSGELVAIKKVLQDKRFKNRELQIM-- 101 IG G FG +Y A + D+G L K Q + K ++Q Sbjct: 43 IGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQ-RAAKPEQIQKWIR 101 Query: 102 -RKLDHCNIVRLRYFFYSSG--EKKDEVYLNLVLDYVPETVYRV----ARHYSRAKQTLP 154 RKL + + + ++ SG +K + Y +++D + ++ A+ +SR Sbjct: 102 TRKLKYLGVPK----YWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRK----T 153 Query: 155 VIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLL---DPDTAVLKLCDFGSA 204 V+ + L ++ L YIH H DIK NLLL +PD L D+G A Sbjct: 154 VLQLSL---RILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVY--LVDYGLA 201 >2W1Z-A nrPDB Length = 368 Score = 33.5 bits (75), Expect = 0.17, Method: Compositional matrix adjust. Identities = 39/164 (23%), Positives = 68/164 (41%), Gaps = 27/164 (16%) Query: 94 KNRELQIMRKLDHCNIVRL-RYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQT 152 K R++ I +LD ++ L R+F Y + + +++L + + ++ H++R + T Sbjct: 141 KKRKM-IRVRLDERDMWVLSRFFLYPRMQSNLHILGDVLLSH--SSTHKSLVHHARLQLT 197 Query: 153 LPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEP 212 L QL R A + +G+ H D + +N+LLD V L F + LVR Sbjct: 198 L----------QLIRLAASLQHYGLVHADFQVRNILLDQRGGVF-LTGF---EHLVRDGA 243 Query: 213 NVSYICSRYYRAPELI---------FGATDYTSSIDVWSAGCVL 247 + R + PE T T D W+ G + Sbjct: 244 SAVSPIGRGFAPPETTAERMLPYRQHHPTLMTFPFDTWTLGLAI 287 >3ZZW-A nrPDB Length = 289 Score = 33.1 bits (74), Expect = 0.24, Method: Compositional matrix adjust. Identities = 28/113 (24%), Positives = 56/113 (49%), Gaps = 9/113 (7%) Query: 164 QLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGE----PNVSYICS 219 Q+ + Y+ S + H+D+ +N+L+ D +K+ D G +++ + S + Sbjct: 136 QIAAGMEYLSSHHVVHKDLATRNVLV-YDKLNVKISDLGLFREVYAADYYKLLGNSLLPI 194 Query: 220 RYYRAPELIFGATDYTSSIDVWSAGCVLAELL-LGQPIFPGDSGVDQLVEIIK 271 R+ +++G ++ D+WS G VL E+ G + G S D +VE+I+ Sbjct: 195 RWMAPEAIMYGK--FSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQD-VVEMIR 244 >5CEK-A nrPDB Length = 263 Score = 33.1 bits (74), Expect = 0.25, Method: Compositional matrix adjust. Identities = 44/202 (21%), Positives = 77/202 (38%), Gaps = 34/202 (16%) Query: 146 YSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAK 205 Y R+++ L Q+ ++A+ H I D+K + + + + Sbjct: 90 YVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDT 149 Query: 206 QLVRGEPNV---SYICSRYYRAPELIFGATDYTS-SIDVWSAGCVLAELLLGQPIFPGDS 261 +++GE + + C Y +PE++ Y+ + DVWS G +L LL+G+ F DS Sbjct: 150 HIMKGEDDALSDKHGCPAYV-SPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPF-HDS 207 Query: 262 GVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLL 321 L I+ +F P+ P+A L LL Sbjct: 208 DPSALFSKIR----------------RGQFCIPE------------HISPKARCLIRSLL 239 Query: 322 EYTPTARLTPLEACAHSFFDEL 343 P+ RLT E H +F+ + Sbjct: 240 RREPSERLTAPEILLHPWFESV 261 >5UU1-A nrPDB Length = 324 Score = 32.7 bits (73), Expect = 0.28, Method: Compositional matrix adjust. Identities = 44/162 (27%), Positives = 73/162 (45%), Gaps = 25/162 (15%) Query: 60 KVIGNGSFGVVYQAKLCDSGELVA---IKKVLQDKRFKNRELQIMRKLDHCNIVR----- 111 K IG+G FG++Y A + E A +K Q+ EL+ +++ + ++ Sbjct: 22 KKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDCIKKWIER 81 Query: 112 --LRYF----FYSSG--EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMY 163 L Y FY SG E K Y +V++ + + +++ K++ V+ + + M Sbjct: 82 KQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQNGTFKKS-TVLQLGIRML 140 Query: 164 QLFRSLAYIHSFGICHRDIKPQNLLL---DPDTAVLKLCDFG 202 + L YIH H DIK NLLL +PD L D+G Sbjct: 141 DV---LEYIHENEYVHGDIKAANLLLGYKNPDQVY--LADYG 177 >6J6I-B nrPDB Length = 351 Score = 32.7 bits (73), Expect = 0.31, Method: Compositional matrix adjust. Identities = 30/114 (26%), Positives = 51/114 (44%), Gaps = 11/114 (9%) Query: 164 QLFRSLAYIHSFG---ICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNV--SYIC 218 ++ ++ Y+H+ I HRD+KP ++ LD + KL D + L G+ + ++ Sbjct: 171 EIANAVTYLHTAFPKIIIHRDVKPMHVFLDKNWTA-KLSDLSFSISLPEGKSRIEAEWVL 229 Query: 219 SRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQP----IFPGD-SGVDQLV 267 + L T DV+S G L ++ G+P I GD G+ LV Sbjct: 230 GTFGYIDPLYHKTCFVTEYTDVYSFGICLLVIITGKPAIMTISDGDLQGILSLV 283 >6DC0-A nrPDB Length = 292 Score = 32.3 bits (72), Expect = 0.35, Method: Compositional matrix adjust. Identities = 44/202 (21%), Positives = 77/202 (38%), Gaps = 34/202 (16%) Query: 146 YSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAK 205 Y R+++ L Q+ ++A+ H I D+K + + + + Sbjct: 87 YVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDT 146 Query: 206 QLVRGEPNV---SYICSRYYRAPELIFGATDYTS-SIDVWSAGCVLAELLLGQPIFPGDS 261 +++GE + + C Y +PE++ Y+ + DVWS G +L LL+G+ F DS Sbjct: 147 HIMKGEDDALSDKHGCPAYV-SPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPF-HDS 204 Query: 262 GVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLL 321 L I+ +F P+ P+A L LL Sbjct: 205 DPSALFSKIR----------------RGQFCIPE------------HISPKARCLIRSLL 236 Query: 322 EYTPTARLTPLEACAHSFFDEL 343 P+ RLT E H +F+ + Sbjct: 237 RREPSERLTAPEILLHPWFESV 258 >3MDY-A nrPDB Length = 337 Score = 32.3 bits (72), Expect = 0.39, Method: Compositional matrix adjust. Identities = 51/217 (23%), Positives = 91/217 (41%), Gaps = 38/217 (17%) Query: 59 TKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKR---FKNRELQIMRKLDHCNIVRLRYF 115 K IG G +G V+ K GE VA+K + F+ E+ + H NI+ Sbjct: 42 VKQIGKGRYGEVWMGKW--RGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILG---- 95 Query: 116 FYSSGEKKDEVY--LNLVLDYVPE-TVYRVARHYS-RAKQTLPVIYVKLYMYQLFRSLAY 171 F ++ K + L L+ DY ++Y + + AK L + Y + L + Sbjct: 96 FIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSV------SGLCH 149 Query: 172 IHSF--------GICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNV-----SYIC 218 +H+ I HRD+K +N+L+ + + D G A + + V + + Sbjct: 150 LHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCC-IADLGLAVKFISDTNEVDIPPNTRVG 208 Query: 219 SRYYRAPELI---FGATDYTSSI--DVWSAGCVLAEL 250 ++ Y PE++ + S I D++S G +L E+ Sbjct: 209 TKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEV 245 >4OAU-C nrPDB Length = 699 Score = 31.6 bits (70), Expect = 0.60, Method: Compositional matrix adjust. Identities = 15/38 (39%), Positives = 25/38 (65%), Gaps = 2/38 (5%) Query: 165 LFRSLAYIH-SFGICHRDIKPQNLLLDPDTAVLKLCDF 201 +F+++ +H S G H+D++PQN+L+D A L DF Sbjct: 448 IFKAVQELHLSCGYTHQDLQPQNILIDSKKAA-HLADF 484 >4H05-A nrPDB Length = 273 Score = 31.6 bits (70), Expect = 0.66, Method: Compositional matrix adjust. Identities = 16/42 (38%), Positives = 22/42 (52%), Gaps = 1/42 (2%) Query: 162 MYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTA-VLKLCDFG 202 + +L R+ +CH D+ P N+LLDP T V L D G Sbjct: 171 LAELERTRPADEDLAVCHGDLCPDNVLLDPRTCEVTGLIDVG 212 >5JFQ-A nrPDB Length = 322 Score = 31.2 bits (69), Expect = 0.78, Method: Compositional matrix adjust. Identities = 20/62 (32%), Positives = 33/62 (53%), Gaps = 11/62 (17%) Query: 136 PETVYRVARHYSRA--KQTLPVIYV-------KLYMYQLFRSLAY--IHSFGICHRDIKP 184 PE +YR ARHY +A K+ PVI + + Y + ++A +H+F + H DI Sbjct: 29 PEGLYRAARHYLKAGGKRLRPVITLLSAEALGEDYRKAIHAAIAIETVHNFTLVHDDIMD 88 Query: 185 QN 186 ++ Sbjct: 89 ED 90 >4BWP-A nrPDB Length = 448 Score = 30.4 bits (67), Expect = 1.6, Method: Compositional matrix adjust. Identities = 17/55 (30%), Positives = 32/55 (58%), Gaps = 2/55 (3%) Query: 98 LQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQT 152 +++ +KL H N+V+LR F + + L LV DY P + +A++++ A +T Sbjct: 97 VEMWKKLQHTNVVQLREVFTTKAFGDNS--LVLVYDYHPGSQTLLAKYFTPAPET 149 >5VE6-A nrPDB Length = 492 Score = 30.0 bits (66), Expect = 1.7, Method: Compositional matrix adjust. Identities = 18/56 (32%), Positives = 26/56 (46%), Gaps = 3/56 (5%) Query: 137 ETVYRVARHYSRAKQTLPVIY---VKLYMYQLFRSLAYIHSFGICHRDIKPQNLLL 189 +T R + + Q P Y V + QL L ++ GI HRD+ +NLLL Sbjct: 186 QTASDFVRDSAASHQAEPEAYERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLL 241 >6EQI-C nrPDB Length = 433 Score = 29.3 bits (64), Expect = 3.6, Method: Compositional matrix adjust. Identities = 35/180 (19%), Positives = 73/180 (40%), Gaps = 28/180 (15%) Query: 168 SLAYIHSFGICHRDIKPQNLLLD-------PDTAVLK----LCDFGSAKQLVRGEPNVSY 216 ++A+++ I HRD+K N+L+D P + LCD + + + Sbjct: 179 AVAHMNIHNISHRDLKSDNILVDLSEGDAYPTIVITDFGCCLCDKQNGLVIPYRSEDQDK 238 Query: 217 ICSRYYRAPEL------IFGATDYTSSIDVWSAGCVLAELL-LGQPIFPGDSGVDQLVEI 269 +R APE+ F +Y S D+W+ G + E+ + P + + Sbjct: 239 GGNRALMAPEIANAKPGTFSWLNYKKS-DLWAVGAIAYEIFNIDNPFYD---------KT 288 Query: 270 IKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARL 329 +K+L +E+ P+ F + ++ ++ R + A ++L + P++ L Sbjct: 289 MKLLSKSYKEEDLPELPDTIPFIIRNLVSNMLSRSTNKRLDCDVAATVAQLYLWAPSSWL 348 >6FUC-A nrPDB Length = 272 Score = 28.9 bits (63), Expect = 3.9, Method: Compositional matrix adjust. Identities = 14/36 (38%), Positives = 21/36 (58%), Gaps = 2/36 (5%) Query: 177 ICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEP 212 +CH D+ N++LDPDT L + F +L R +P Sbjct: 185 VCHGDLCLPNIILDPDT--LDVAGFIDLGRLGRADP 218 >4L00-A nrPDB Length = 304 Score = 28.9 bits (63), Expect = 4.3, Method: Compositional matrix adjust. Identities = 24/93 (25%), Positives = 44/93 (47%), Gaps = 9/93 (9%) Query: 164 QLFRSLAYIHSFGICHRDIKPQNLLL-----DPDTA-VLKLCDFGSAKQLVRGEPNVSYI 217 QL +L+Y+ + H ++ +NLLL D + +KL D G ++ + + I Sbjct: 141 QLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERI 200 Query: 218 CSRYYRAPELIFGATDYTSSIDVWSAGCVLAEL 250 + APE + + + + + D WS G L E+ Sbjct: 201 ---PWIAPECVEDSKNLSVAADKWSFGTTLWEI 230 >5OWX-1 nrPDB Length = 182 Score = 28.9 bits (63), Expect = 4.4, Method: Compositional matrix adjust. Identities = 20/62 (32%), Positives = 29/62 (46%), Gaps = 4/62 (6%) Query: 350 LPNGRDTPALFNFTTQELSSNPPLATILIP---PHARIQAAASPPANATAASDTNAGDRG 406 +PNG AL N + + P + +P PH R+ A N +ASD+ +GD G Sbjct: 63 VPNGAPEAALSNTSNPTAYNKAPFTRLALPYTAPH-RVLATVYDGTNKYSASDSRSGDLG 121 Query: 407 QT 408 T Sbjct: 122 ST 123 >4M69-B nrPDB Length = 283 Score = 28.9 bits (63), Expect = 4.4, Method: Compositional matrix adjust. Identities = 42/175 (24%), Positives = 71/175 (40%), Gaps = 20/175 (11%) Query: 95 NRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLP 154 N E++ M+K D NI+R+ K E ++V++Y R ++ L Sbjct: 56 NDEIKTMKKFDSPNILRIFGICIDQTVKPPE--FSIVMEYCE---LGTLRELLDREKDLT 110 Query: 155 VIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAK--------- 205 + L + + R L +H HR+I + L+ V KL F +K Sbjct: 111 MSVRSLLVLRAARGLYRLHHSETLHRNISSSSFLVAGGYQV-KLAGFELSKTQNSISRTA 169 Query: 206 QLVRGEPNVSYICSRYYRAPELIFGA-TDYTSSIDVWSAGCVLAELLLGQPIFPG 259 + + E + S I Y +PE + Y +++S G VL E+ G+ F G Sbjct: 170 KSTKAERSSSTI----YVSPERLKNPFCLYDIKAEIYSFGIVLWEIATGKIPFEG 220 >3ENH-A nrPDB Length = 540 Score = 28.5 bits (62), Expect = 5.3, Method: Compositional matrix adjust. Identities = 18/66 (27%), Positives = 28/66 (42%), Gaps = 4/66 (6%) Query: 141 RVARHYSRAKQTLPVIYVKLYM-YQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLC 199 R+ Y K VI L + Y++ + +H + H D+ N + D D L + Sbjct: 415 RIMMSYINGKLAKDVIEDNLDIAYKIGEIVGKLHKNDVIHNDLTTSNFIFDKD---LYII 471 Query: 200 DFGSAK 205 DFG K Sbjct: 472 DFGLGK 477 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 5AIR-A nrPDB 653 0.0 4E7W-A nrPDB 456 e-129 3E3P-A nrPDB 373 e-104 3EB0-A nrPDB 356 9e-99 2BPM-A nrPDB 316 1e-86 3NIZ-A nrPDB 311 4e-85 1CM8-A nrPDB 306 1e-83 4EWQ-A nrPDB 304 5e-83 4BBM-A nrPDB 302 2e-82 4MYG-A nrPDB 302 2e-82 4AGU-A nrPDB 302 2e-82 5Z33-A nrPDB 301 4e-82 6DTL-A nrPDB 299 1e-81 2F9G-A nrPDB 298 2e-81 5NGU-A nrPDB 298 3e-81 3OHT-A nrPDB 298 3e-81 6GU6-A nrPDB 297 5e-81 4QTB-A nrPDB 297 6e-81 3GC9-A nrPDB 297 6e-81 4ZSG-A nrPDB 296 2e-80 4IC8-A nrPDB 295 2e-80 4AU8-A nrPDB 295 3e-80 1V0B-A nrPDB 294 6e-80 3OZ6-A nrPDB 293 1e-79 4QNY-A nrPDB 292 2e-79 5JN2-A nrPDB 291 4e-79 1UA2-A nrPDB 290 9e-79 5EFQ-A nrPDB 290 9e-79 4MVF-A nrPDB 289 2e-78 4KRC-A nrPDB 288 2e-78 5G6V-A nrPDB 288 3e-78 4NST-A nrPDB 285 2e-77 5AWM-A nrPDB 283 1e-76 1JNK-A nrPDB 282 2e-76 3MA6-A nrPDB 281 3e-76 2XS0-A nrPDB 281 5e-76 3HZT-A nrPDB 279 2e-75 1G3N-A nrPDB 279 2e-75 3FI2-A nrPDB 278 3e-75 2VN9-A nrPDB 278 3e-75 3E7O-A nrPDB 278 5e-75 3DXN-A nrPDB 277 6e-75 4BGQ-A nrPDB 277 7e-75 3ZDU-A nrPDB 276 9e-75 3PG1-A nrPDB 276 1e-74 3LIJ-A nrPDB 275 2e-74 3NCG-A nrPDB 274 4e-74 3GC0-A nrPDB 274 6e-74 4O2Z-A nrPDB 272 2e-73 2V7O-A nrPDB 272 2e-73 3MIA-A nrPDB 271 4e-73 5U6Y-A nrPDB 271 5e-73 3DFA-A nrPDB 270 9e-73 3RP9-A nrPDB 269 1e-72 4RGJ-A nrPDB 269 2e-72 2I6L-A nrPDB 268 2e-72 2BDW-A nrPDB 268 2e-72 4YZB-A nrPDB 266 9e-72 3Q5I-A nrPDB 265 2e-71 5XZW-A nrPDB 264 7e-71 2VZ6-A nrPDB 263 7e-71 3BHH-A nrPDB 263 8e-71 3SOA-A nrPDB 262 2e-70 2W96-B nrPDB 262 2e-70 5FG8-A nrPDB 261 4e-70 3UC3-A nrPDB 260 6e-70 3N9X-A nrPDB 260 9e-70 5YKS-A nrPDB 259 1e-69 3KK8-A nrPDB 259 2e-69 6O6Q-A nrPDB 258 3e-69 3NIE-A nrPDB 258 4e-69 3MN3-A nrPDB 258 5e-69 2J90-A nrPDB 256 1e-68 5ZTN-A nrPDB 256 1e-68 5IG1-A nrPDB 255 2e-68 3TAC-A nrPDB 255 2e-68 5ES1-A nrPDB 254 4e-68 5Y86-A nrPDB 254 6e-68 2JC6-A nrPDB 253 9e-68 4PDS-A nrPDB 253 2e-67 4FG9-A nrPDB 252 2e-67 2QNJ-A nrPDB 252 2e-67 5WAX-A nrPDB 251 3e-67 2JAM-A nrPDB 251 4e-67 5KZ7-A nrPDB 251 6e-67 3F3Z-A nrPDB 250 7e-67 5D9K-A nrPDB 250 8e-67 3IS5-A nrPDB 249 1e-66 2YAB-A nrPDB 249 1e-66 4MD7-E nrPDB 249 1e-66 1PHK-A nrPDB 249 2e-66 2A27-A nrPDB 249 2e-66 3ZUT-A nrPDB 248 3e-66 4L42-A nrPDB 248 4e-66 2OU7-A nrPDB 248 5e-66 2YCR-A nrPDB 248 5e-66 3COM-A nrPDB 247 5e-66 3H4J-B nrPDB 247 6e-66 4CZT-A nrPDB 246 1e-65 4NIF-A nrPDB 246 2e-65 3I6U-A nrPDB 246 2e-65 6FDY-U nrPDB 244 5e-65 3UDB-A nrPDB 244 6e-65 2Z7Q-A nrPDB 243 1e-64 2X4F-A nrPDB 243 1e-64 4JG6-A nrPDB 243 1e-64 1ZWS-A nrPDB 243 1e-64 4CFH-A nrPDB 243 1e-64 3D2K-A nrPDB 243 2e-64 4REW-A nrPDB 242 2e-64 4RED-A nrPDB 242 3e-64 4RA4-A nrPDB 242 3e-64 2JDO-A nrPDB 241 5e-64 4LG4-A nrPDB 241 5e-64 2F57-A nrPDB 241 5e-64 2W4O-A nrPDB 240 7e-64 4J52-A nrPDB 240 7e-64 4JXF-A nrPDB 240 7e-64 2YZA-A nrPDB 240 1e-63 4UZD-A nrPDB 239 1e-63 6AO5-A nrPDB 239 1e-63 4CFF-A nrPDB 239 2e-63 5EZV-A nrPDB 239 2e-63 3GUB-A nrPDB 239 2e-63 2HAK-A nrPDB 239 2e-63 5KCV-A nrPDB 239 2e-63 2ZMD-A nrPDB 238 3e-63 5D7A-A nrPDB 238 3e-63 4RLP-A nrPDB 238 3e-63 3DB8-A nrPDB 238 4e-63 3MV5-A nrPDB 238 4e-63 2Y7J-A nrPDB 238 5e-63 4KS7-A nrPDB 238 5e-63 3TXO-A nrPDB 238 5e-63 1FOT-A nrPDB 237 7e-63 6C9D-A nrPDB 237 8e-63 3PFQ-A nrPDB 237 9e-63 4D2V-A nrPDB 236 1e-62 4CQG-A nrPDB 236 2e-62 6FD3-A nrPDB 236 2e-62 3UTO-A nrPDB 236 2e-62 3HDN-A nrPDB 235 2e-62 4XBR-A nrPDB 235 2e-62 2I0E-A nrPDB 235 2e-62 2Q0N-A nrPDB 235 2e-62 6FYV-A nrPDB 235 3e-62 4JDH-A nrPDB 235 3e-62 2PVN-A nrPDB 234 5e-62 4FIE-A nrPDB 234 5e-62 5X8I-B nrPDB 234 5e-62 5JZN-A nrPDB 234 7e-62 1KOA-A nrPDB 234 7e-62 1NY3-A nrPDB 234 8e-62 2WO6-A nrPDB 234 8e-62 2OZA-A nrPDB 233 1e-61 4D28-A nrPDB 233 1e-61 6HMD-A nrPDB 233 1e-61 3KA0-A nrPDB 233 1e-61 1KOB-A nrPDB 232 1e-61 4B6L-A nrPDB 232 2e-61 5XVU-A nrPDB 232 3e-61 6EII-A nrPDB 231 3e-61 4I6B-A nrPDB 230 7e-61 4CRL-A nrPDB 230 8e-61 6ED6-A nrPDB 230 8e-61 5F9E-A nrPDB 230 1e-60 3ORZ-A nrPDB 229 2e-60 6E9W-A nrPDB 229 2e-60 3DAK-A nrPDB 229 2e-60 3RAW-A nrPDB 228 3e-60 4YNZ-A nrPDB 228 3e-60 2UV2-A nrPDB 228 3e-60 3NYO-A nrPDB 227 5e-60 6HXF-B nrPDB 227 5e-60 2HW6-A nrPDB 227 6e-60 6CMJ-A nrPDB 227 7e-60 5X3F-B nrPDB 227 8e-60 3Q53-A nrPDB 227 9e-60 3FXW-A nrPDB 227 9e-60 6E2O-A nrPDB 226 2e-59 5N23-A nrPDB 226 2e-59 3TKU-A nrPDB 226 2e-59 1VZO-A nrPDB 224 4e-59 5J5T-A nrPDB 224 4e-59 4WB7-A nrPDB 224 7e-59 5DBX-A nrPDB 223 1e-58 2XIK-A nrPDB 222 2e-58 1U5R-A nrPDB 222 2e-58 2GCD-A nrPDB 222 2e-58 4QMW-A nrPDB 221 3e-58 5YV8-A nrPDB 221 4e-58 4LFI-A nrPDB 221 5e-58 4TNB-A nrPDB 221 7e-58 3HKO-A nrPDB 220 8e-58 3KN6-A nrPDB 220 8e-58 5UNP-A nrPDB 220 1e-57 4AW2-A nrPDB 219 1e-57 2JD5-A nrPDB 219 2e-57 4U41-A nrPDB 219 2e-57 5LOH-A nrPDB 219 2e-57 4CSV-A nrPDB 219 2e-57 6QAU-A nrPDB 218 3e-57 5DYK-A nrPDB 218 3e-57 4B8L-A nrPDB 218 4e-57 4WNO-A nrPDB 218 4e-57 4FZF-B nrPDB 218 4e-57 4IAN-A nrPDB 217 8e-57 3ALO-A nrPDB 216 1e-56 6GQK-A nrPDB 216 2e-56 6CKI-A nrPDB 215 2e-56 1TKI-A nrPDB 215 3e-56 4AF3-A nrPDB 215 3e-56 2VD5-A nrPDB 214 4e-56 2WQN-A nrPDB 214 7e-56 5FET-A nrPDB 213 1e-55 3G0E-A nrPDB 213 1e-55 4C0T-A nrPDB 212 2e-55 3A8W-A nrPDB 212 2e-55 4GS6-A nrPDB 211 4e-55 4OLI-A nrPDB 211 4e-55 3LM0-A nrPDB 211 5e-55 3QA8-A nrPDB 210 8e-55 4YHJ-A nrPDB 210 1e-54 6BDL-A nrPDB 209 2e-54 4FR4-A nrPDB 209 2e-54 6CQF-A nrPDB 209 2e-54 4APC-A nrPDB 207 6e-54 4CRS-A nrPDB 207 7e-54 5TQX-A nrPDB 207 7e-54 6DBN-A nrPDB 207 8e-54 4PWN-A nrPDB 207 9e-54 2BRG-A nrPDB 206 1e-53 3VN9-A nrPDB 206 1e-53 3FME-A nrPDB 206 2e-53 6GVJ-A nrPDB 206 2e-53 3C51-A nrPDB 206 2e-53 5O2C-A nrPDB 206 2e-53 4YFF-A nrPDB 205 2e-53 5O2B-A nrPDB 205 4e-53 4KIK-B nrPDB 204 5e-53 2WTK-C nrPDB 204 5e-53 5VO2-A nrPDB 203 1e-52 3BEA-A nrPDB 203 1e-52 5MJB-A nrPDB 203 1e-52 3HMP-A nrPDB 203 1e-52 3M42-A nrPDB 203 1e-52 4OTD-A nrPDB 203 2e-52 5AP3-A nrPDB 202 2e-52 6DBM-A nrPDB 202 2e-52 3KRL-A nrPDB 202 3e-52 4UY9-A nrPDB 202 3e-52 4UYA-A nrPDB 202 3e-52 2WTK-B nrPDB 201 4e-52 5KKR-C nrPDB 201 5e-52 4E20-A nrPDB 201 5e-52 6CCF-A nrPDB 201 5e-52 5H2U-A nrPDB 201 6e-52 3BGP-A nrPDB 201 7e-52 3EQC-A nrPDB 201 7e-52 2XNP-A nrPDB 200 9e-52 2R2P-A nrPDB 200 1e-51 3QGY-A nrPDB 200 1e-51 3BBT-B nrPDB 199 1e-51 4AN9-A nrPDB 199 1e-51 4RC3-A nrPDB 199 2e-51 3DKO-A nrPDB 199 2e-51 5L6P-A nrPDB 199 2e-51 3DTC-A nrPDB 199 2e-51 2OGV-A nrPDB 199 2e-51 6BXI-A nrPDB 199 3e-51 2VWV-A nrPDB 198 3e-51 2W1I-A nrPDB 198 4e-51 5TUR-A nrPDB 198 4e-51 2Y6O-A nrPDB 197 5e-51 2A1A-B nrPDB 197 5e-51 1ZXE-A nrPDB 197 8e-51 5UUU-A nrPDB 197 1e-50 3PVW-A nrPDB 196 1e-50 6NPU-A nrPDB 196 1e-50 4XEY-B nrPDB 196 2e-50 5GRN-A nrPDB 196 2e-50 3UIU-A nrPDB 196 2e-50 3LLT-A nrPDB 195 3e-50 1JPA-A nrPDB 195 3e-50 4P5Q-A nrPDB 195 3e-50 3IO7-A nrPDB 195 4e-50 2FO0-A nrPDB 195 4e-50 4R7H-A nrPDB 194 5e-50 4X7Q-B nrPDB 194 6e-50 5X5O-A nrPDB 194 6e-50 4PDO-A nrPDB 194 9e-50 2X7G-A nrPDB 193 1e-49 5GNK-A nrPDB 193 1e-49 3PPZ-A nrPDB 193 1e-49 3TT0-A nrPDB 192 2e-49 2DQ7-X nrPDB 192 2e-49 4E93-A nrPDB 192 2e-49 2H8H-A nrPDB 192 3e-49 3QUP-A nrPDB 191 4e-49 3GQL-A nrPDB 191 5e-49 5SYS-A nrPDB 191 5e-49 3CJF-A nrPDB 191 6e-49 3LZB-A nrPDB 191 6e-49 1S9I-A nrPDB 191 6e-49 6F3F-A nrPDB 191 8e-49 4EBW-A nrPDB 190 1e-48 4HVI-A nrPDB 190 1e-48 4K33-A nrPDB 190 1e-48 2PSQ-A nrPDB 190 1e-48 5U6B-A nrPDB 190 1e-48 5A46-A nrPDB 189 2e-48 4H1J-A nrPDB 189 2e-48 2J0K-A nrPDB 189 2e-48 3DLS-A nrPDB 189 3e-48 5VD3-A nrPDB 188 3e-48 5AMN-A nrPDB 188 5e-48 5HVK-A nrPDB 187 7e-48 4WUA-A nrPDB 187 7e-48 3ORP-A nrPDB 187 8e-48 3SXS-A nrPDB 187 8e-48 5HI2-A nrPDB 187 1e-47 4HZS-A nrPDB 186 1e-47 5EG3-A nrPDB 186 1e-47 4JLC-A nrPDB 186 2e-47 1U54-B nrPDB 186 2e-47 5HIE-A nrPDB 185 3e-47 4XCU-A nrPDB 185 3e-47 3PP0-A nrPDB 185 3e-47 4M7I-A nrPDB 185 4e-47 4EQM-A nrPDB 184 4e-47 3KUL-B nrPDB 184 5e-47 5U6C-A nrPDB 184 6e-47 4LRM-A nrPDB 184 6e-47 2PL0-A nrPDB 184 7e-47 5O0Y-A nrPDB 184 8e-47 1U59-A nrPDB 184 9e-47 2OZO-A nrPDB 184 9e-47 5X02-A nrPDB 183 1e-46 4XUF-A nrPDB 183 1e-46 4EUU-A nrPDB 183 1e-46 4EUT-A nrPDB 183 1e-46 6CTH-A nrPDB 183 1e-46 1FVR-A nrPDB 183 1e-46 3A4O-X nrPDB 183 1e-46 5B2L-A nrPDB 183 2e-46 2BUJ-A nrPDB 182 2e-46 5FM2-A nrPDB 182 3e-46 6NT9-A nrPDB 181 4e-46 6O8B-A nrPDB 181 4e-46 3OMV-A nrPDB 181 5e-46 4C59-A nrPDB 181 5e-46 5UIU-A nrPDB 180 7e-46 5HLW-A nrPDB 180 1e-45 2HK5-A nrPDB 179 2e-45 4NEU-A nrPDB 178 4e-45 1K9A-A nrPDB 178 4e-45 3C1X-A nrPDB 178 4e-45 1LUF-A nrPDB 178 4e-45 2RIO-A nrPDB 178 4e-45 4XLV-A nrPDB 178 5e-45 3ZBF-A nrPDB 177 6e-45 1AD5-A nrPDB 177 1e-44 4IDT-A nrPDB 176 1e-44 6HV0-A nrPDB 176 1e-44 1BYG-A nrPDB 176 2e-44 4TPT-A nrPDB 175 2e-44 4F0G-A nrPDB 175 2e-44 4PL5-B nrPDB 175 3e-44 5TOS-A nrPDB 174 4e-44 4Y83-A nrPDB 171 5e-43 3PLS-A nrPDB 170 7e-43 3AOX-A nrPDB 170 1e-42 2PMN-X nrPDB 168 3e-42 6J5U-C nrPDB 168 4e-42 4F9B-A nrPDB 168 4e-42 4G3E-A nrPDB 167 6e-42 3I81-A nrPDB 167 1e-41 3UIM-A nrPDB 167 1e-41 5TE0-A nrPDB 166 1e-41 5LPZ-A nrPDB 166 2e-41 5LPV-A nrPDB 166 2e-41 3QD2-B nrPDB 164 5e-41 6B2Q-A nrPDB 164 6e-41 4X3F-A nrPDB 164 6e-41 4OW8-A nrPDB 164 6e-41 5WNO-A nrPDB 163 1e-40 4FL3-A nrPDB 161 4e-40 5C26-A nrPDB 161 6e-40 3LMG-A nrPDB 158 4e-39 5L2Q-C nrPDB 157 7e-39 5XD6-A nrPDB 156 2e-38 5IKW-A nrPDB 153 2e-37 3HNG-A nrPDB 152 2e-37 2QKW-B nrPDB 152 3e-37 3SOC-A nrPDB 152 3e-37 3G2F-A nrPDB 151 6e-37 3VHK-A nrPDB 148 4e-36 4M66-A nrPDB 148 5e-36 4JRN-A nrPDB 148 6e-36 5AR8-A nrPDB 147 1e-35 5E8V-A nrPDB 147 1e-35 2QLU-A nrPDB 146 1e-35 2H34-A nrPDB 145 2e-35 4LQP-A nrPDB 144 7e-35 2Y4I-B nrPDB 142 2e-34 5J0A-A nrPDB 141 5e-34 6BFN-A nrPDB 140 1e-33 5VC6-A nrPDB 137 1e-32 4BTK-A nrPDB 135 5e-32 4NFN-A nrPDB 134 6e-32 4RT7-A nrPDB 133 1e-31 2CHL-A nrPDB 132 4e-31 2C47-A nrPDB 130 9e-31 4TN6-A nrPDB 129 2e-30 2CMW-A nrPDB 128 6e-30 2PZI-A nrPDB 127 7e-30 4Y12-A nrPDB 127 8e-30 5X18-A nrPDB 126 1e-29 5FQD-C nrPDB 126 2e-29 3SV0-A nrPDB 125 3e-29 5OAT-A nrPDB 124 8e-29 5X1R-A nrPDB 122 2e-28 5UV4-A nrPDB 120 1e-27 4IX6-A nrPDB 118 4e-27 5M07-A nrPDB 117 7e-27 4XHH-A nrPDB 117 8e-27 4XHL-A nrPDB 115 3e-26 6G4J-A nrPDB 106 2e-23 5CLR-A nrPDB 91 7e-19 3BYV-A nrPDB 76 2e-14 3DZO-A nrPDB 70 1e-12 Sequences not found previously or not previously below threshold: 2XYN-A nrPDB 195 4e-50 6E4F-A nrPDB 186 1e-47 4XI2-A nrPDB 184 4e-47 4AT3-A nrPDB 183 1e-46 4Y93-A nrPDB 182 2e-46 3V5Q-A nrPDB 179 2e-45 5KMM-A nrPDB 177 6e-45 6FEX-A nrPDB 173 1e-43 6BSD-A nrPDB 170 8e-43 6FER-A nrPDB 167 1e-41 3ZZW-A nrPDB 151 5e-37 5WNL-A nrPDB 149 2e-36 3MDY-A nrPDB 149 2e-36 3Q4U-A nrPDB 149 3e-36 1PY5-A nrPDB 145 3e-35 3MY0-A nrPDB 139 2e-33 5CEK-A nrPDB 125 4e-29 6DC0-A nrPDB 125 4e-29 5VDK-A nrPDB 125 5e-29 4NT4-A nrPDB 124 8e-29 4L00-A nrPDB 118 4e-27 4MWI-A nrPDB 118 5e-27 1CSN-A nrPDB 115 3e-26 4BTF-A nrPDB 112 2e-25 4M69-B nrPDB 111 6e-25 5USZ-A nrPDB 108 5e-24 6EQI-C nrPDB 101 7e-22 3REP-A nrPDB 99 3e-21 4L68-A nrPDB 99 5e-21 5C01-A nrPDB 95 4e-20 4WOV-A nrPDB 95 4e-20 6J6I-B nrPDB 90 1e-18 4I94-A nrPDB 90 2e-18 5UU1-A nrPDB 84 1e-16 4O1O-A nrPDB 79 4e-15 4CI6-B nrPDB 78 7e-15 2RSV-A nrPDB 75 6e-14 2LAV-A nrPDB 75 7e-14 5DMZ-A nrPDB 73 2e-13 6EWX-A nrPDB 68 1e-11 4OAU-C nrPDB 67 1e-11 5VE6-A nrPDB 64 1e-10 2W1Z-A nrPDB 62 4e-10 6BHC-A nrPDB 61 7e-10 2JII-A nrPDB 59 3e-09 6EAS-A nrPDB 56 3e-08 4CYJ-A nrPDB 56 3e-08 6M7Z-A nrPDB 55 5e-08 5GZ9-A nrPDB 53 2e-07 5GZA-A nrPDB 53 2e-07 4BWP-A nrPDB 49 4e-06 4AZW-A nrPDB 49 4e-06 4AZV-A nrPDB 48 5e-06 6G38-A nrPDB 48 9e-06 4WWA-A nrPDB 48 1e-05 3Q60-A nrPDB 48 1e-05 3ENH-A nrPDB 48 1e-05 4CZY-B nrPDB 46 3e-05 1TQM-A nrPDB 41 8e-04 5YK0-A nrPDB 39 0.004 6FAI-l nrPDB 38 0.010 4BVU-A nrPDB 37 0.018 5I35-A nrPDB 35 0.083 6EF6-A nrPDB 34 0.094 6DFL-A nrPDB 33 0.33 3J4J-A nrPDB 32 0.37 5U75-A nrPDB 32 0.47 1IOM-A nrPDB 32 0.64 5YZ0-C nrPDB 32 0.76 >5AIR-A nrPDB Length = 430 Score = 653 bits (1684), Expect = 0.0, Method: Composition-based stats. Identities = 417/419 (99%), Positives = 417/419 (99%) Query: 2 SGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKV 61 S RPRTTSFAESCKPVQQPSAFGSMKVS DKDGSKVTTVVATPGQGPDRPQEVSYTDTKV Sbjct: 12 SSRPRTTSFAESCKPVQQPSAFGSMKVSIDKDGSKVTTVVATPGQGPDRPQEVSYTDTKV 71 Query: 62 IGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGE 121 IGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGE Sbjct: 72 IGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGE 131 Query: 122 KKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRD 181 KKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRD Sbjct: 132 KKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRD 191 Query: 182 IKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVW 241 IKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVW Sbjct: 192 IKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVW 251 Query: 242 SAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPW 301 SAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPW Sbjct: 252 SAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPW 311 Query: 302 TKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFN 361 TKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFN Sbjct: 312 TKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFN 371 Query: 362 FTTQELSSNPPLATILIPPHARIQAAASPPANATAASDTNAGDRGQTNNAASASASNST 420 FTTQELSSNPPLATILIPPHARIQAAASPPANATAASDTNAGDRGQTNNAASASASNST Sbjct: 372 FTTQELSSNPPLATILIPPHARIQAAASPPANATAASDTNAGDRGQTNNAASASASNST 430 >4E7W-A nrPDB Length = 394 Score = 456 bits (1173), Expect = e-129, Method: Composition-based stats. Identities = 248/365 (67%), Positives = 305/365 (83%), Gaps = 2/365 (0%) Query: 21 SAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGE 80 + +K++ D +KV V+A+ G+ ++ +E++YT+ KVIGNGSFGVV+QAKL +S E Sbjct: 8 APLNGVKLNPLDDPNKVIKVLASDGKTGEQ-REIAYTNCKVIGNGSFGVVFQAKLVESDE 66 Query: 81 LVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVY 140 VAIKKVLQDKRFKNRELQIMR + H N+V L+ FFYS+G+KKDEV+LNLVL+YVPETVY Sbjct: 67 -VAIKKVLQDKRFKNRELQIMRIVKHPNVVDLKAFFYSNGDKKDEVFLNLVLEYVPETVY 125 Query: 141 RVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCD 200 R +RHY++ KQT+P++ +KLYMYQL RSLAYIHS GICHRDIKPQNLLLDP + VLKL D Sbjct: 126 RASRHYAKLKQTMPMLLIKLYMYQLLRSLAYIHSIGICHRDIKPQNLLLDPPSGVLKLID 185 Query: 201 FGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGD 260 FGSAK L+ GEPNVSYICSRYYRAPELIFGAT+YT++ID+WS GCV+AEL+ GQP+FPG+ Sbjct: 186 FGSAKILIAGEPNVSYICSRYYRAPELIFGATNYTTNIDIWSTGCVMAELMQGQPLFPGE 245 Query: 261 SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRL 320 SG+DQLVEIIKVLGTP+REQI+ MNPNY E KFPQI+ HP++KVFRPRTPP+AI L SRL Sbjct: 246 SGIDQLVEIIKVLGTPSREQIKTMNPNYMEHKFPQIRPHPFSKVFRPRTPPDAIDLISRL 305 Query: 321 LEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPP 380 LEYTP+ARLT +EA H FFDELR ++PNGR+ P LFN+T +ELS P L + L+P Sbjct: 306 LEYTPSARLTAIEALCHPFFDELRTGEARMPNGRELPPLFNWTKEELSVRPDLISRLVPQ 365 Query: 381 HARIQ 385 HA + Sbjct: 366 HAEAE 370 >3E3P-A nrPDB Length = 360 Score = 373 bits (958), Expect = e-104, Method: Composition-based stats. Identities = 162/345 (46%), Positives = 227/345 (65%), Gaps = 10/345 (2%) Query: 34 GSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRF 93 GS ++ A R + + ++ G G+FG V K +G VAIKKV+QD RF Sbjct: 3 GSMMSLNAAAAADERSRKEMDRFQVERMAGQGTFGTVQLGKEKSTGMSVAIKKVIQDPRF 62 Query: 94 KNRELQIMRKL---DHCNIVRLRYFFYSSGEK-KDEVYLNLVLDYVPETVYRVARHYSRA 149 +NRELQIM+ L H NIV+L+ +FY+ GE+ + ++YLN+V++YVP+T++R R+Y R Sbjct: 63 RNRELQIMQDLAVLHHPNIVQLQSYFYTLGERDRRDIYLNVVMEYVPDTLHRCCRNYYRR 122 Query: 150 KQTLPVIYVKLYMYQLFRSLAYIH--SFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQL 207 + P I +K++++QL RS+ +H S +CHRDIKP N+L++ LKLCDFGSAK+L Sbjct: 123 QVAPPPILIKVFLFQLIRSIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKL 182 Query: 208 VRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLV 267 EPNV+YICSRYYRAPELIFG YT+++D+WS GC+ AE++LG+PIF GD+ QL Sbjct: 183 SPSEPNVAYICSRYYRAPELIFGNQHYTTAVDIWSVGCIFAEMMLGEPIFRGDNSAGQLH 242 Query: 268 EIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRT---PPEAIALCSRLLEYT 324 EI++VLG P+RE +R++NP++T+ K PW+ VF + EA L S LL+Y Sbjct: 243 EIVRVLGCPSREVLRKLNPSHTDVDLYNSKGIPWSNVFSDHSLKDAKEAYDLLSALLQYL 302 Query: 325 PTARLTPLEACAHSFFDELRDPNVKLPNGRDTPA-LFNFTTQELS 368 P R+ P EA H +FDEL DP KLPN +D P LF F E+ Sbjct: 303 PEERMKPYEALCHPYFDELHDPATKLPNNKDLPEDLFRFLPNEIE 347 >3EB0-A nrPDB Length = 383 Score = 356 bits (914), Expect = 9e-99, Method: Composition-based stats. Identities = 166/357 (46%), Positives = 237/357 (66%), Gaps = 41/357 (11%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYF 115 Y+ K +G GSFG+V + +SG+ A+KKVLQD R+KNREL IM+ LDH NI++L + Sbjct: 9 YSLGKTLGTGSFGIVCEVFDIESGKRFALKKVLQDPRYKNRELDIMKVLDHVNIIKLVDY 68 Query: 116 FYSSGEKK--------------------------------DEVYLNLVLDYVPETVYRVA 143 FY++G+++ YLN++++YVP+T+++V Sbjct: 69 FYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNVIMEYVPDTLHKVL 128 Query: 144 RHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGS 203 + + R+ +++P+ + +Y+YQLFR++ +IHS GICHRDIKPQNLL++ LKLCDFGS Sbjct: 129 KSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLLVNSKDNTLKLCDFGS 188 Query: 204 AKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGV 263 AK+L+ EP+V+YICSR+YRAPEL+ GAT+YT SID+WS GCV EL+LG+P+F G++ + Sbjct: 189 AKKLIPSEPSVAYICSRFYRAPELMLGATEYTPSIDLWSIGCVFGELILGKPLFSGETSI 248 Query: 264 DQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEY 323 DQLV II+++GTPT+EQ+ MNP+YTE +FP +KA W K+ TP AI L ++L Y Sbjct: 249 DQLVRIIQIMGTPTKEQMIRMNPHYTEVRFPTLKAKDWRKILPEGTPSLAIDLLEQILRY 308 Query: 324 TPTARLTPLEACAHSFFDELRDP-------NVKLPNG--RDTPALFNFTTQELSSNP 371 P R+ P EA AH FFD LR+ N P+G ++ P LFNF+ ELS P Sbjct: 309 EPDLRINPYEAMAHPFFDHLRNSYESEVKNNSNFPHGVNQNIPQLFNFSPYELSIIP 365 >2BPM-A nrPDB Length = 309 Score = 316 bits (809), Expect = 1e-86, Method: Composition-based stats. Identities = 102/309 (33%), Positives = 173/309 (55%), Gaps = 20/309 (6%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN------RELQIMRKLDHCN 108 ++ + IG G++GVVY+A+ +GE+VA+KK+ D + RE+ ++++L+H N Sbjct: 8 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 67 Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRS 168 IV+L + E L LV +++ + + + + LP+ +K Y++QL + Sbjct: 68 IVKLLDVIH------TENKLYLVFEFLHQDLKKFMDASALTGIPLPL--IKSYLFQLLQG 119 Query: 169 LAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQL-VRGEPNVSYICSRYYRAPEL 227 LA+ HS + HRD+KPQNLL++ + A +KL DFG A+ V + + +YRAPE+ Sbjct: 120 LAFCHSHRVLHRDLKPQNLLINTEGA-IKLADFGLARAFGVPVRTYTHEVVTLWYRAPEI 178 Query: 228 IFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMN-- 285 + G Y++++D+WS GC+ AE++ + +FPGDS +DQL I + LGTP + Sbjct: 179 LLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSM 238 Query: 286 PNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRD 345 P+Y + FP+ ++KV P + +L S++L Y P R++ A AH FF ++ Sbjct: 239 PDY-KPSFPKWARQDFSKVVPP-LDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTK 296 Query: 346 PNVKLPNGR 354 P L R Sbjct: 297 PVPHLRLER 305 >3NIZ-A nrPDB Length = 311 Score = 311 bits (796), Expect = 4e-85, Method: Composition-based stats. Identities = 102/302 (33%), Positives = 169/302 (55%), Gaps = 22/302 (7%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN------RELQIMRKLDHCNI 109 Y + +G G++GVVY+AK G +VA+K++ D + RE+ ++++L H NI Sbjct: 23 YQKLEKVGEGTYGVVYKAKDSQ-GRIVALKRIRLDAEDEGIPSTAIREISLLKELHHPNI 81 Query: 110 VRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 169 V L +S E L LV +++ + + +V K L +K+Y+YQL R + Sbjct: 82 VSLIDVIHS------ERCLTLVFEFMEKDLKKVL---DENKTGLQDSQIKIYLYQLLRGV 132 Query: 170 AYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQL-VRGEPNVSYICSRYYRAPELI 228 A+ H I HRD+KPQNLL++ D A LKL DFG A+ + + + +YRAP+++ Sbjct: 133 AHCHQHRILHRDLKPQNLLINSDGA-LKLADFGLARAFGIPVRSYTHEVVTLWYRAPDVL 191 Query: 229 FGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMN--P 286 G+ Y++S+D+WS GC+ AE++ G+P+FPG + DQL +I +LGTP + ++ P Sbjct: 192 MGSKKYSTSVDIWSIGCIFAEMITGKPLFPGVTDDDQLPKIFSILGTPNPREWPQVQELP 251 Query: 287 NYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDP 346 + + F + PW+ + P E I L S +L + P R++ +A H +F +L DP Sbjct: 252 LWKQRTFQVFEKKPWSSII-PGFCQEGIDLLSNMLCFDPNKRISARDAMNHPYFKDL-DP 309 Query: 347 NV 348 + Sbjct: 310 QI 311 >1CM8-A nrPDB Length = 367 Score = 306 bits (783), Expect = 1e-83, Method: Composition-based stats. Identities = 97/315 (30%), Positives = 164/315 (52%), Gaps = 20/315 (6%) Query: 46 QGPDRPQEVS--YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKV---LQDKRFKNR---E 97 + EV Y D + +G+G++G V A +G VAIKK+ Q + F R E Sbjct: 15 EVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRE 74 Query: 98 LQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIY 157 L++++ + H N++ L F D LV+ ++ + ++ +H + L Sbjct: 75 LRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKH-----EKLGEDR 129 Query: 158 VKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYI 217 ++ +YQ+ + L YIH+ GI HRD+KP NL ++ D LK+ DFG A+Q Y+ Sbjct: 130 IQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCE-LKILDFGLARQ--ADSEMTGYV 186 Query: 218 CSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPT 277 +R+YRAPE+I YT ++D+WS GC++AE++ G+ +F G +DQL EI+KV GTP Sbjct: 187 VTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPP 246 Query: 278 REQIREMNPNYTEF---KFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEA 334 E ++ + + + P+++ + + P A+ L ++L R+T EA Sbjct: 247 AEFVQRLQSDEAKNYMKGLPELEKKDFASILT-NASPLAVNLLEKMLVLDAEQRVTAGEA 305 Query: 335 CAHSFFDELRDPNVK 349 AH +F+ L D + Sbjct: 306 LAHPYFESLHDTEDE 320 >4EWQ-A nrPDB Length = 383 Score = 304 bits (778), Expect = 5e-83, Method: Composition-based stats. Identities = 93/316 (29%), Positives = 164/316 (51%), Gaps = 23/316 (7%) Query: 43 TPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ------DKRFKNR 96 T + P+R Y + +G+G++G V A +G VA+KK+ + + R Sbjct: 39 TIWEVPER-----YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYR 93 Query: 97 ELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVI 156 EL++++ + H N++ L F + ++ + LV + + + + Q L Sbjct: 94 ELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVK-----CQKLTDD 148 Query: 157 YVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSY 216 +V+ +YQ+ R L YIHS I HRD+KP NL ++ D LK+ DFG A+ + Y Sbjct: 149 HVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCE-LKILDFGLARH--TDDEMTGY 205 Query: 217 ICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTP 276 + +R+YRAPE++ Y ++D+WS GC++AELL G+ +FPG +DQL I++++GTP Sbjct: 206 VATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTP 265 Query: 277 TREQIREMNPNYTE---FKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLE 333 E +++++ Q+ + VF P A+ L ++L R+T + Sbjct: 266 GAELLKKISSESARNYIQSLTQMPKMNFANVFI-GANPLAVDLLEKMLVLDSDKRITAAQ 324 Query: 334 ACAHSFFDELRDPNVK 349 A AH++F + DP+ + Sbjct: 325 ALAHAYFAQYHDPDDE 340 >4BBM-A nrPDB Length = 331 Score = 302 bits (774), Expect = 2e-82, Method: Composition-based stats. Identities = 96/295 (32%), Positives = 154/295 (52%), Gaps = 19/295 (6%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQD------KRFKNRELQIMRKLDHCNI 109 Y + ++G GS+G+V + + D+G +VAIKK L+ K+ RE++++++L H N+ Sbjct: 27 YENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHENL 86 Query: 110 VRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 169 V L LV ++V T+ + L V+ Y++Q+ + Sbjct: 87 VNLLEVCKKKKRW------YLVFEFVDHTILDDLELF---PNGLDYQVVQKYLFQIINGI 137 Query: 170 AYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLV-RGEPNVSYICSRYYRAPELI 228 + HS I HRDIKP+N+L+ + V+KLCDFG A+ L GE + +R+YRAPEL+ Sbjct: 138 GFCHSHNIIHRDIKPENILVSQ-SGVVKLCDFGFARTLAAPGEVYDDEVATRWYRAPELL 196 Query: 229 FGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGT--PTREQIREMNP 286 G Y ++DVW+ GC++ E+ +G+P+FPGDS +DQL I+ LG P +++ NP Sbjct: 197 VGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNP 256 Query: 287 NYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFD 341 + + P+IK + P+ I L + L P R E H FF Sbjct: 257 VFAGVRLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQ 311 >4MYG-A nrPDB Length = 372 Score = 302 bits (774), Expect = 2e-82, Method: Composition-based stats. Identities = 105/337 (31%), Positives = 168/337 (49%), Gaps = 24/337 (7%) Query: 22 AFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGEL 81 GS K G V T + P +Y +G+G++G V A SGE Sbjct: 16 PRGSHMSLIRKKGFYKQDVNKTAWELPK-----TYVSPTHVGSGAYGSVCSAIDKRSGEK 70 Query: 82 VAIKKV---LQDKRFKNR---ELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYV 135 VAIKK+ Q + F R EL +++ + H N++ L F + ++ LV+ ++ Sbjct: 71 VAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFM 130 Query: 136 PETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAV 195 + ++ ++ +YQ+ + L YIHS G+ HRD+KP NL ++ D Sbjct: 131 QTDLQKIM------GMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCE- 183 Query: 196 LKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQP 255 LK+ DFG A+ Y+ +R+YRAPE+I Y ++D+WS GC++AE+L G+ Sbjct: 184 LKILDFGLARH--ADAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKT 241 Query: 256 IFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTE---FKFPQIKAHPWTKVFRPRTPPE 312 +F G +DQL +I+KV G P E ++++N + PQ +T++F PR P+ Sbjct: 242 LFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLF-PRASPQ 300 Query: 313 AIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVK 349 A L ++LE RLT +A H FF+ RDP + Sbjct: 301 AADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEE 337 >4AGU-A nrPDB Length = 311 Score = 302 bits (773), Expect = 2e-82, Method: Composition-based stats. Identities = 107/312 (34%), Positives = 163/312 (52%), Gaps = 20/312 (6%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQD------KRFKNRELQIMRKLDHCNI 109 Y IG GS+GVV++ + D+G++VAIKK L+ K+ RE++++++L H N+ Sbjct: 5 YEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKHPNL 64 Query: 110 VRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 169 V L F + + L+LV +Y TV Y R +P VK +Q +++ Sbjct: 65 VNLLEVF------RRKRRLHLVFEYCDHTVLHELDRYQRG---VPEHLVKSITWQTLQAV 115 Query: 170 AYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLV-RGEPNVSYICSRYYRAPELI 228 + H HRD+KP+N+L+ + V+KLCDFG A+ L + + +R+YR+PEL+ Sbjct: 116 NFCHKHNCIHRDVKPENILITKHS-VIKLCDFGFARLLTGPSDYYDDEVATRWYRSPELL 174 Query: 229 FGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGT--PTREQIREMNP 286 G T Y +DVW+ GCV AELL G P++PG S VDQL I K LG P +Q+ N Sbjct: 175 VGDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQ 234 Query: 287 NYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDP 346 ++ K P + ++ P A+ L L PT RLT + H +F+ +R+ Sbjct: 235 YFSGVKIPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTERLTCEQLLHHPYFENIREI 294 Query: 347 NVKLPNGRDTPA 358 L D PA Sbjct: 295 E-DLAKEHDKPA 305 >5Z33-A nrPDB Length = 425 Score = 301 bits (771), Expect = 4e-82, Method: Composition-based stats. Identities = 107/326 (32%), Positives = 167/326 (51%), Gaps = 27/326 (8%) Query: 53 EVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQD------KRFKNRELQIMRKLD- 105 + YT TK +G G++G+V A + E VAIKKV + RE+++++ Sbjct: 30 DERYTVTKELGQGAYGIVCAAVNNQTSEGVAIKKVTNVFSKKILAKRALREIKLLQHFRG 89 Query: 106 HCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQL 165 H NI L + +E YL + + + + R+ Q L + + ++YQ+ Sbjct: 90 HRNITCLYDMDIPRPDNFNETYLYE--ELMECDLAAII----RSGQPLTDAHFQSFIYQI 143 Query: 166 FRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEP-----NVSYICSR 220 L YIHS + HRD+KP NLL++ D LK+CDFG A+ Y+ +R Sbjct: 144 LCGLKYIHSANVLHRDLKPGNLLVNADCE-LKICDFGLARGFSVDPEENAGYMTEYVATR 202 Query: 221 YYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQ 280 +YRAPE++ YT +IDVWS GC+LAELL G+P F G VDQL +I+ +LGTP E Sbjct: 203 WYRAPEIMLSFQSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQILHILGTPNEET 262 Query: 281 IREM-NPNYTEF--KFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAH 337 + + +P E+ P + P+ +F P P+A+ L R+L + P++R++ +A H Sbjct: 263 LSRIGSPRAQEYVRNLPFMAKKPFPTLF-PNANPDALDLLDRMLAFDPSSRISVEQALEH 321 Query: 338 SFFDELRDPNVKLPNGRDTPALFNFT 363 + D + + D P FNF Sbjct: 322 PYLHIWHDAS----DEPDCPTTFNFD 343 >6DTL-A nrPDB Length = 364 Score = 299 bits (766), Expect = 1e-81, Method: Composition-based stats. Identities = 105/317 (33%), Positives = 172/317 (54%), Gaps = 17/317 (5%) Query: 62 IGNGSFGVVYQAKLCDSGELVAIKKVLQ------DKRFKNRELQIMRKLDHCNIVRLRYF 115 IG G++G+V A ++ E VAIKK+ D + RE++++R +DH NIV +R Sbjct: 38 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 97 Query: 116 FYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSF 175 + + + + ++++ R+ Q L + + ++YQ+ R L YIHS Sbjct: 98 IPPPLRNAFND-VYIAYELMDTDLHQII----RSNQALSEEHCQYFLYQILRGLKYIHSA 152 Query: 176 GICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYT 235 + HRD+KP NLLL+ + LK+CDFG A+ + Y+ +R+YRAPEL+ ++DYT Sbjct: 153 NVLHRDLKPSNLLLNANCD-LKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYT 211 Query: 236 SSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEF--KF 293 ++IDVWS GC+ EL+ +P+FPG V QL +++++GTP+ E++ +N N + + Sbjct: 212 AAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQL 271 Query: 294 PQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNG 353 P T F P P AI L ++L + P R+T L+A AH + + L D + + Sbjct: 272 PPYPRQSITDKF-PTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISDEP--E 328 Query: 354 RDTPALFNFTTQELSSN 370 P F+F LS Sbjct: 329 CTIPFNFDFENHALSEE 345 >2F9G-A nrPDB Length = 353 Score = 298 bits (764), Expect = 2e-81, Method: Composition-based stats. Identities = 98/332 (29%), Positives = 165/332 (49%), Gaps = 28/332 (8%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKR-----FKNRELQIMRKLDHCNI 109 + ++G G++GVV A +GE+VAIKK+ + RE++I++ H NI Sbjct: 12 DFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENI 71 Query: 110 VRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 169 + + ++ + ++ + + ++RV + Q L +++ ++YQ R++ Sbjct: 72 ITIFNI-QRPDSFENFNEVYIIQELMQTDLHRVI-----STQMLSDDHIQYFIYQTLRAV 125 Query: 170 AYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEP-----------NVSYIC 218 +H + HRD+KP NLL++ + LK+CDFG A+ + Y+ Sbjct: 126 KVLHGSNVIHRDLKPSNLLINSNCD-LKVCDFGLARIIDESAADNSEPTGQQSGMTEYVA 184 Query: 219 SRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTR 278 +R+YRAPE++ + Y+ ++DVWS GC+LAEL L +PIFPG QL+ I ++GTP Sbjct: 185 TRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHS 244 Query: 279 EQIREM--NPNYTEF--KFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEA 334 + +P E+ P A P K+F PR P+ I L R+L + P R+T EA Sbjct: 245 DNDLRCIESPRAREYIKSLPMYPAAPLEKMF-PRVNPKGIDLLQRMLVFDPAKRITAKEA 303 Query: 335 CAHSFFDELRDPNVKLPNGRDTPALFNFTTQE 366 H + DPN + P+ F F + Sbjct: 304 LEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYK 335 >5NGU-A nrPDB Length = 381 Score = 298 bits (764), Expect = 3e-81, Method: Composition-based stats. Identities = 101/328 (30%), Positives = 172/328 (52%), Gaps = 22/328 (6%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKV--LQDKRFKNR---ELQIMRKLDHCNI 109 YT+ IG G++G+V A + VAIKK+ + + + R E++I+ + H NI Sbjct: 43 RYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENI 102 Query: 110 VRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 169 + + + ++ + + +V D + +Y++ + Q L ++ ++YQ+ R L Sbjct: 103 IGINDIIRAPTIEQMKD-VYIVQDLMETDLYKLLK-----TQHLSNDHICYFLYQILRGL 156 Query: 170 AYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVS----YICSRYYRAP 225 YIHS + HRD+KP NLLL+ T LK+CDFG A+ + Y+ +R+YRAP Sbjct: 157 KYIHSANVLHRDLKPSNLLLNT-TCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAP 215 Query: 226 ELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQ---IR 282 E++ + YT SID+WS GC+LAE+L +PIFPG +DQL I+ +LG+P++E I Sbjct: 216 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 275 Query: 283 EMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDE 342 + P PW ++F P +A+ L ++L + P R+ +A AH + ++ Sbjct: 276 NLKARNYLLSLPHKNKVPWNRLF-PNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQ 334 Query: 343 LRDPNVKLPNGRDTPALFNFTTQELSSN 370 DP+ + + P F+ +L Sbjct: 335 YYDPSDEP--IAEAPFKFDMELDDLPKE 360 >3OHT-A nrPDB Length = 389 Score = 298 bits (763), Expect = 3e-81, Method: Composition-based stats. Identities = 97/337 (28%), Positives = 168/337 (49%), Gaps = 26/337 (7%) Query: 43 TPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ------DKRFKNR 96 T + P+R Y +G+G++G V + SG +A+KK+ + + R Sbjct: 45 TIWEVPER-----YQTLSPVGSGAYGSVCSSYDVKSGLKIAVKKLSRPFQSIIHAKRTYR 99 Query: 97 ELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVI 156 EL++++ + H N++ L F + ++ + LV + + + + Q L Sbjct: 100 ELRLLKHMKHENVIGLLDVFTPATSLEEFNDVYLVTHLMGADLNNIVK-----CQKLTDD 154 Query: 157 YVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSY 216 +V+ +YQ+ R L YIHS I HRD+KP NL ++ D LK+ DFG A+ + Y Sbjct: 155 HVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCE-LKILDFGLARH--TDDEMTGY 211 Query: 217 ICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTP 276 + +R+YRAPE++ Y ++D+WS GC++AELL G+ +FPG ++QL +I+++ GTP Sbjct: 212 VATRWYRAPEIMLNWMHYNMTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTP 271 Query: 277 TREQIREMNPNYTE---FKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLE 333 I M + PQ+ + VF P A+ L ++L R+T E Sbjct: 272 PASVISRMPSHEARNYINSLPQMPKRNFADVFI-GANPLAVDLLEKMLVLDTDKRITASE 330 Query: 334 ACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSN 370 A AH +F + DP+ + + P +F +++L Sbjct: 331 ALAHPYFSQYHDPDDEPESE---PYDQSFESRQLEIE 364 >6GU6-A nrPDB Length = 302 Score = 297 bits (761), Expect = 5e-81, Method: Composition-based stats. Identities = 91/304 (29%), Positives = 157/304 (51%), Gaps = 17/304 (5%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN------RELQIMRKLDHCN 108 YT + IG G++GVVY+ + +G++VA+KK+ + + RE+ ++++L H N Sbjct: 8 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN 67 Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRS 168 IV L+ + L L+ +++ + + Q + VK Y+YQ+ + Sbjct: 68 IVSLQDVL------MQDSRLYLIFEFLSMDLKKYLDSIP-PGQYMDSSLVKSYLYQILQG 120 Query: 169 LAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQL-VRGEPNVSYICSRYYRAPEL 227 + + HS + HRD+KPQNLL+D D +KL DFG A+ + + + +YR+PE+ Sbjct: 121 IVFCHSRRVLHRDLKPQNLLID-DKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEV 179 Query: 228 IFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNP- 286 + G+ Y++ +D+WS G + AEL +P+F GDS +DQL I + LGTP E E+ Sbjct: 180 LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESL 239 Query: 287 NYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDP 346 + FP+ K + L S++L Y P R++ A H +F++L + Sbjct: 240 QDYKNTFPKWKPGSLAS-HVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQ 298 Query: 347 NVKL 350 K+ Sbjct: 299 IKKM 302 >4QTB-A nrPDB Length = 380 Score = 297 bits (761), Expect = 6e-81, Method: Composition-based stats. Identities = 113/352 (32%), Positives = 177/352 (50%), Gaps = 34/352 (9%) Query: 43 TPGQGPDRPQEVS------------YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKV--L 88 T G GP P EV YT + IG G++G+V A VAIKK+ Sbjct: 18 TEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPF 77 Query: 89 QDKRFKNR---ELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARH 145 + + + R E+QI+ + H N++ +R +S + + +V D + +Y++ + Sbjct: 78 EHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRD-VYIVQDLMETDLYKLLKS 136 Query: 146 YSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAK 205 Q L ++ ++YQ+ R L YIHS + HRD+KP NLL++ T LK+CDFG A+ Sbjct: 137 -----QQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINT-TCDLKICDFGLAR 190 Query: 206 QLVRGEPNVS----YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDS 261 + Y+ +R+YRAPE++ + YT SID+WS GC+LAE+L +PIFPG Sbjct: 191 IADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKH 250 Query: 262 GVDQLVEIIKVLGTPTREQ---IREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCS 318 +DQL I+ +LG+P++E I M P W K+F P++ +A+ L Sbjct: 251 YLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLF-PKSDSKALDLLD 309 Query: 319 RLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSN 370 R+L + P R+T EA AH + ++ DP + P F +L Sbjct: 310 RMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEE--PFTFAMELDDLPKE 359 >3GC9-A nrPDB Length = 370 Score = 297 bits (761), Expect = 6e-81, Method: Composition-based stats. Identities = 105/346 (30%), Positives = 172/346 (49%), Gaps = 33/346 (9%) Query: 43 TPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ------DKRFKNR 96 T + P R Q + +G+G++G V A + VA+KK+ + R R Sbjct: 22 TVWEVPQRLQG-----LRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYR 76 Query: 97 ELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVI 156 EL++++ L H N++ L F + +D + LV + + + + Q L Sbjct: 77 ELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKS-----QALSDE 131 Query: 157 YVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSY 216 +V+ +YQL R L YIHS GI HRD+KP N+ ++ D+ L++ DFG A+Q E Y Sbjct: 132 HVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDSE-LRILDFGLARQ--ADEEMTGY 188 Query: 217 ICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTP 276 + +R+YRAPE++ Y ++D+WS GC++AELL G+ +FPG +DQL I++V+GTP Sbjct: 189 VATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTP 248 Query: 277 TREQIREMNPNYTE---FKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLE 333 + E + +++ + P + + +FR P AI L R+L R++ E Sbjct: 249 SPEVLAKISSEHARTYIQSLPPMPQKDLSSIFR-GANPLAIDLLGRMLVLDSDQRVSAAE 307 Query: 334 ACAHSFFDELRDPNVKL----------PNGRDTPALFNFTTQELSS 369 A AH++F + DP + R T QE+ S Sbjct: 308 ALAHAYFSQYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLS 353 >4ZSG-A nrPDB Length = 347 Score = 296 bits (757), Expect = 2e-80, Method: Composition-based stats. Identities = 103/331 (31%), Positives = 172/331 (51%), Gaps = 22/331 (6%) Query: 54 VSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ------DKRFKNRELQIMRKLDHC 107 Y + IGNG++GVV A+ +G+ VAIKK+ + + REL+I++ H Sbjct: 7 DEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHD 66 Query: 108 NIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFR 167 NI+ ++ + + + +VLD + ++++ + Q L + +V+ ++YQL R Sbjct: 67 NIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIH----SSQPLTLEHVRYFLYQLLR 122 Query: 168 SLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEP-----NVSYICSRYY 222 L Y+HS + HRD+KP NLL++ + LK+ DFG A+ L Y+ +R+Y Sbjct: 123 GLKYMHSAQVIHRDLKPSNLLVNENCE-LKIGDFGMARGLCTSPAEHQYFMTEYVATRWY 181 Query: 223 RAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIR 282 RAPEL+ +YT +ID+WS GC+ E+L + +FPG + V QL I+ VLGTP+ I+ Sbjct: 182 RAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQ 241 Query: 283 EMNPNYTE---FKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSF 339 + P + PW V+ P +A++L R+L + P+AR++ A H F Sbjct: 242 AVGAERVRAYIQSLPPRQPVPWETVY-PGADRQALSLLGRMLRFEPSARISAAAALRHPF 300 Query: 340 FDELRDPNVKLPNGRDTPALFNFTTQELSSN 370 + DP+ + P F F + L+ Sbjct: 301 LAKYHDPDDEPDCA--PPFDFAFDREALTRE 329 >4IC8-A nrPDB Length = 442 Score = 295 bits (755), Expect = 2e-80, Method: Composition-based stats. Identities = 103/331 (31%), Positives = 172/331 (51%), Gaps = 22/331 (6%) Query: 54 VSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ------DKRFKNRELQIMRKLDHC 107 Y + IGNG++GVV A+ +G+ VAIKK+ + + REL+I++ H Sbjct: 55 DEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHD 114 Query: 108 NIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFR 167 NI+ ++ + + + +VLD + ++++ + Q L + +V+ ++YQL R Sbjct: 115 NIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIH----SSQPLTLEHVRYFLYQLLR 170 Query: 168 SLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEP-----NVSYICSRYY 222 L Y+HS + HRD+KP NLL++ + LK+ DFG A+ L Y+ +R+Y Sbjct: 171 GLKYMHSAQVIHRDLKPSNLLVNENCE-LKIGDFGMARGLCTSPAEHQYFMTEYVATRWY 229 Query: 223 RAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIR 282 RAPEL+ +YT +ID+WS GC+ E+L + +FPG + V QL I+ VLGTP+ I+ Sbjct: 230 RAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQ 289 Query: 283 EMNPNYTE---FKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSF 339 + P + PW V+ P +A++L R+L + P+AR++ A H F Sbjct: 290 AVGAERVRAYIQSLPPRQPVPWETVY-PGADRQALSLLGRMLRFEPSARISAAAALRHPF 348 Query: 340 FDELRDPNVKLPNGRDTPALFNFTTQELSSN 370 + DP+ + P F F + L+ Sbjct: 349 LAKYHDPDDEPDCA--PPFDFAFDREALTRE 377 >4AU8-A nrPDB Length = 296 Score = 295 bits (755), Expect = 3e-80, Method: Composition-based stats. Identities = 100/299 (33%), Positives = 157/299 (52%), Gaps = 18/299 (6%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDK------RFKNRELQIMRKLDHCNI 109 Y + IG G++G V++AK ++ E+VA+K+V D RE+ ++++L H NI Sbjct: 8 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 67 Query: 110 VRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 169 VRL +S + L LV ++ + + +++ L VK +++QL + L Sbjct: 68 VRLHDVLHS------DKKLTLVFEFCDQ---DLKKYFDSCNGDLDPEIVKSFLFQLLKGL 118 Query: 170 AYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVS-YICSRYYRAPELI 228 + HS + HRD+KPQNLL++ + LKL DFG A+ S + + +YR P+++ Sbjct: 119 GFCHSRNVLHRDLKPQNLLINRNGE-LKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVL 177 Query: 229 FGATDYTSSIDVWSAGCVLAELL-LGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPN 287 FGA Y++SID+WSAGC+ AEL G+P+FPG+ DQL I ++LGTPT EQ M Sbjct: 178 FGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKL 237 Query: 288 YTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDP 346 +P A P+ L LL+ P R++ EA H +F + P Sbjct: 238 PDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 296 >1V0B-A nrPDB Length = 288 Score = 294 bits (752), Expect = 6e-80, Method: Composition-based stats. Identities = 92/295 (31%), Positives = 158/295 (53%), Gaps = 20/295 (6%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN------RELQIMRKLDHCNI 109 Y + IG G++GVVY+A+ GE A+KK+ +K + RE+ I+++L H NI Sbjct: 4 YHGLEKIGEGTYGVVYKAQNNY-GETFALKKIRLEKEDEGIPSTTIREISILKELKHSNI 62 Query: 110 VRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 169 V+L ++ L LV +++ + + ++ + L + K ++ QL + Sbjct: 63 VKLYDVIHTKKR------LVLVFEHLDQDLKKLLDVC---EGGLESVTAKSFLLQLLNGI 113 Query: 170 AYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQL-VRGEPNVSYICSRYYRAPELI 228 AY H + HRD+KPQNLL++ + LK+ DFG A+ + + + +YRAP+++ Sbjct: 114 AYCHDRRVLHRDLKPQNLLINREGE-LKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVL 172 Query: 229 FGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNY 288 G+ Y+++ID+WS GC+ AE++ G P+FPG S DQL+ I ++LGTP + + Sbjct: 173 MGSKKYSTTIDIWSVGCIFAEMVNGAPLFPGVSEADQLMRIFRILGTPNSKNWPNVTELP 232 Query: 289 T-EFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDE 342 + F + PW + F I L S++L+ P R+T +A H++F E Sbjct: 233 KYDPNFTVYEPLPW-ESFLKGLDESGIDLLSKMLKLDPNQRITAKQALEHAYFKE 286 >3OZ6-A nrPDB Length = 388 Score = 293 bits (749), Expect = 1e-79, Method: Composition-based stats. Identities = 102/348 (29%), Positives = 169/348 (48%), Gaps = 57/348 (16%) Query: 49 DRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ------DKRFKNRELQIMR 102 DR Y K +G G++G+V+++ +GE+VA+KK+ D + RE+ I+ Sbjct: 4 DRHVLRKYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQNSTDAQRTFREIMILT 63 Query: 103 KLD-HCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLY 161 +L H NIV L + ++ + LV DY+ ++ V R L ++ + Sbjct: 64 ELSGHENIVNLLNVLRADNDRD----VYLVFDYMETDLHAVIR-----ANILEPVHKQYV 114 Query: 162 MYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLV------------- 208 +YQL + + Y+HS G+ HRD+KP N+LL+ + V K+ DFG ++ V Sbjct: 115 VYQLIKVIKYLHSGGLLHRDMKPSNILLNAECHV-KVADFGLSRSFVNIRRVTNNIPLSI 173 Query: 209 --------RGEP-NVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPG 259 +P Y+ +R+YRAPE++ G+T YT ID+WS GC+L E+L G+PIFPG Sbjct: 174 NENTENFDDDQPILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGKPIFPG 233 Query: 260 DSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------PWTKVFR 306 S ++QL II V+ P+ E + + + + +K W + Sbjct: 234 SSTMNQLERIIGVIDFPSNEDVESIQSPFAKTMIESLKEKVEIRQSNKRDIFTKWKNLLL 293 Query: 307 PRTP-----PEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVK 349 P EA+ L +LL++ P R++ +A H F +PN + Sbjct: 294 KINPKADCNEEALDLLDKLLQFNPNKRISANDALKHPFVSIFHNPNEE 341 >4QNY-A nrPDB Length = 354 Score = 292 bits (748), Expect = 2e-79, Method: Composition-based stats. Identities = 106/326 (32%), Positives = 173/326 (53%), Gaps = 23/326 (7%) Query: 53 EVSYTDTKVIGNGSFGVVYQAKL-CDSGELVAIKKVLQD-------KRFKNRELQIMRKL 104 + Y ++IG GS+GVV +A+ LVA+K+V ++ + RE++++ Sbjct: 19 DDRYLLERIIGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEEVILAKRILREIKLLAHF 78 Query: 105 DHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQ 164 + NI+ LR + + + +V+D + + +V R+ Q L +++ ++YQ Sbjct: 79 NDDNIIGLRNILTPEDPENFD-HFYIVMDIMETDLKQVL----RSGQELTEAHIQFFIYQ 133 Query: 165 LFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVR-GEPNVSYICSRYYR 223 R+L IHS G+ HRDI P N+L++ + LK+CDFG AK+ GE Y+ R+YR Sbjct: 134 ALRALHIIHSAGVIHRDITPANILVNTNCD-LKICDFGLAKEENDQGEYMTDYVTMRWYR 192 Query: 224 APELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIRE 283 APEL+ DY++ IDVW GC+L ELL +P+F G V+QL +I+ V+GTP+ E I Sbjct: 193 APELVMEDKDYSAQIDVWGIGCILGELLGSRPLFQGKDRVNQLDKIVDVIGTPSEEDINS 252 Query: 284 MNPNYTEFKFPQIKAHP---WTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF 340 + + + + P W + + P PEA+ L +L + P R+T L+A H F Sbjct: 253 VGSSAAQKYLKKKSHRPQADWRQRY-PTASPEALDLLRHMLVFNPKRRITVLQAMRHPFL 311 Query: 341 DELRDPNVKLPNGRDTPALFNFTTQE 366 ++L D + + ALF F E Sbjct: 312 EQLHDD----ADDNLSYALFRFDENE 333 >5JN2-A nrPDB Length = 525 Score = 291 bits (745), Expect = 4e-79, Method: Composition-based stats. Identities = 101/364 (27%), Positives = 151/364 (41%), Gaps = 61/364 (16%) Query: 18 QQPSAFGSMKVSRDKDGSKVTT-------VVATPG---QGPDRPQEVSYTDTKVIGNGSF 67 QQ S G G T + ATPG Q Y +V+G GSF Sbjct: 21 QQESTLGGAAGEPRSRGHAAGTSGGPGDHLHATPGMFVQHSTAIFSDRYKGQRVLGKGSF 80 Query: 68 GVVYQAKLCDSGELVAIKKVLQ-------DKRFKNRELQIMRKLDHCNIVRLRYFFYSSG 120 G V K +G+ A+K + + DK RE+Q++++LDH NI++L FF G Sbjct: 81 GEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDHPNIMKLYEFFEDKG 140 Query: 121 EKKDEVYLNLVLD-YVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICH 179 Y LV + Y ++ R + + Q+ + Y+H I H Sbjct: 141 ------YFYLVGEVYTGGELFDEIISRKR----FSEVDAARIIRQVLSGITYMHKNKIVH 190 Query: 180 RDIKPQNLLLDPDT--AVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSS 237 RD+KP+NLLL+ + A +++ DFG + + I + YY APE++ G Y Sbjct: 191 RDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVLHGT--YDEK 248 Query: 238 IDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIK 297 DVWS G +L LL G P F G + D L ++ K T F+ PQ Sbjct: 249 CDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYT---------------FELPQ-- 291 Query: 298 AHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTP 357 W KV A L ++L Y P+ R++ +A H + + + D P Sbjct: 292 ---WKKV-----SESAKDLIRKMLTYVPSMRISARDALDHEWIQTYTKEQISV----DVP 339 Query: 358 ALFN 361 +L N Sbjct: 340 SLDN 343 >1UA2-A nrPDB Length = 346 Score = 290 bits (742), Expect = 9e-79, Method: Composition-based stats. Identities = 104/315 (33%), Positives = 154/315 (48%), Gaps = 24/315 (7%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFK---------NRELQIMRKLD 105 Y +G G F VY+A+ ++ ++VAIKK+ R + RE++++++L Sbjct: 11 RYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS 70 Query: 106 HCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQL 165 H NI+ L F + ++LV D++ + + + L ++K YM Sbjct: 71 HPNIIGLLDAFGH------KSNISLVFDFMETDLEVIIKD---NSLVLTPSHIKAYMLMT 121 Query: 166 FRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLV-RGEPNVSYICSRYYRA 224 + L Y+H I HRD+KP NLLLD + VLKL DFG AK + +R+YRA Sbjct: 122 LQGLEYLHQHWILHRDLKPNNLLLD-ENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRA 180 Query: 225 PELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREM 284 PEL+FGA Y +D+W+ GC+LAELLL P PGDS +DQL I + LGTPT EQ +M Sbjct: 181 PELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDM 240 Query: 285 NPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDEL- 343 F P +F + + L L + P AR+T +A +F Sbjct: 241 CSLPDYVTFKSFPGIPLHHIFSAAGD-DLLDLIQGLFLFNPCARITATQALKMKYFSNRP 299 Query: 344 -RDPNVKLPNGRDTP 357 P +LP + P Sbjct: 300 GPTPGCQLPR-PNCP 313 >5EFQ-A nrPDB Length = 347 Score = 290 bits (741), Expect = 9e-79, Method: Composition-based stats. Identities = 96/330 (29%), Positives = 155/330 (46%), Gaps = 32/330 (9%) Query: 54 VSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN------RELQIMRKLDHC 107 + +IG G++G VY+A+ D+GE+VA+KKV D + RE++I+R+L H Sbjct: 11 DKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQ 70 Query: 108 NIVRLRYFFYSSGE----KKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMY 163 +I+ ++ + KKD+ LV +Y+ + + ++K +M Sbjct: 71 SIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLES---GLVHFNENHIKSFMR 127 Query: 164 QLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGE--PNVSYICSRY 221 QL L Y H HRDIK N+LL+ + +KL DFG A+ E P + + + + Sbjct: 128 QLMEGLDYCHKKNFLHRDIKCSNILLN-NRGQIKLADFGLARLYSSEESRPYTNKVITLW 186 Query: 222 YRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQI 281 YR PEL+ G YT +IDVWS GC+L EL +PIF + + QL I ++ G+P Sbjct: 187 YRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVW 246 Query: 282 REMNPNYTEFKFPQIKAHPWTKVFRPRTPPE-------AIALCSRLLEYTPTARLTPLEA 334 ++ K P K +R + E A+ L +L P+ R T +A Sbjct: 247 PDV------IKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQA 300 Query: 335 CAHSFFDEL---RDPNVKLPNGRDTPALFN 361 F ++ + P LP +D L++ Sbjct: 301 LQCEFLRDVEPSKMPPPDLPLWQDCHELWS 330 >4MVF-A nrPDB Length = 506 Score = 289 bits (740), Expect = 2e-78, Method: Composition-based stats. Identities = 90/333 (27%), Positives = 151/333 (45%), Gaps = 43/333 (12%) Query: 53 EVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDK-RFKNR---ELQIMRKLDHCN 108 E Y + +G G++G VY+ + +L AIK+ +D+ + NR E++IM+KLDH N Sbjct: 56 EDKYIIDEKLGQGTYGCVYKGIDKVTNQLYAIKEEKKDRLKNINRFFQEIEIMKKLDHPN 115 Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRS 168 IV+L + +++ Y+ L+++ R + M Q+F + Sbjct: 116 IVKLYETY------ENDNYIYLIMELCSG---RELFDSIIENGSFTEKNAATIMKQIFSA 166 Query: 169 LAYIHSFGICHRDIKPQNLLLDPDT--AVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPE 226 + Y+HS I HRD+KP+N L + ++LK+ DFG +K L GE + + YY AP+ Sbjct: 167 IFYLHSLNIVHRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFTTTKAGTPYYVAPQ 226 Query: 227 LIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNP 286 ++ G Y D+WS+G ++ LL G P F GD+ + L ++ K Sbjct: 227 VLDG--KYDKKCDIWSSGVIMYTLLCGYPPFYGDTDNEVLKKVKK--------------- 269 Query: 287 NYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDP 346 EF F + + W + +A L ++LL Y P R T EA H + ++ Sbjct: 270 --GEFCFYE---NDWGSI-----SSDAKNLITKLLTYNPNERCTIEEALNHPWITQMTKS 319 Query: 347 NVKLP-NGRDTPALFNFTTQELSSNPPLATILI 378 + + + L NF + L I Sbjct: 320 HEHVELSSTLLKNLKNFKKENELKKIALTIIAK 352 >4KRC-A nrPDB Length = 317 Score = 288 bits (738), Expect = 2e-78, Method: Composition-based stats. Identities = 93/305 (30%), Positives = 150/305 (49%), Gaps = 20/305 (6%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN-----RELQIMRKLDHCNI 109 + + +GNG++ VY+ +G VA+K+V D RE+ +M++L H NI Sbjct: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENI 65 Query: 110 VRLRYFFYSSGEKKDEVYLNLVLDYVPETV--YRVARHYSRAKQTLPVIYVKLYMYQLFR 167 VRL + E L LV +++ + Y +R + L + VK + +QL + Sbjct: 66 VRLYDVIH------TENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 Query: 168 SLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQL-VRGEPNVSYICSRYYRAPE 226 LA+ H I HRD+KPQNLL++ LKL DFG A+ + S + + +YRAP+ Sbjct: 120 GLAFCHENKILHRDLKPQNLLINKRGQ-LKLGDFGLARAFGIPVNTFSSEVVTLWYRAPD 178 Query: 227 LIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNP 286 ++ G+ Y++SID+WS GC+LAE++ G+P+FPG + +QL I ++GTP + Sbjct: 179 VLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTK 238 Query: 287 NYT-EFKFPQIKAHPWTKVFRPRTPP----EAIALCSRLLEYTPTARLTPLEACAHSFFD 341 Q +V +P T + LL+ P RL+ +A H +F Sbjct: 239 LPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFA 298 Query: 342 ELRDP 346 E Sbjct: 299 EYYHH 303 >5G6V-A nrPDB Length = 324 Score = 288 bits (737), Expect = 3e-78, Method: Composition-based stats. Identities = 98/329 (29%), Positives = 171/329 (51%), Gaps = 22/329 (6%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRF-----KNRELQIMRKLDHCNI 109 +Y +G G++ VY+ K + LVA+K++ + RE+ +++ L H NI Sbjct: 3 TYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANI 62 Query: 110 VRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 169 V L + E L LV +Y+ + + ++ + + VKL+++QL R L Sbjct: 63 VTLHDIIH------TEKSLTLVFEYLDK---DLKQYLDDCGNIINMHNVKLFLFQLLRGL 113 Query: 170 AYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAK-QLVRGEPNVSYICSRYYRAPELI 228 AY H + HRD+KPQNLL++ + LKL DFG A+ + + + + + + +YR P+++ Sbjct: 114 AYCHRQKVLHRDLKPQNLLIN-ERGELKLADFGLARAKSIPTKTYDNEVVTLWYRPPDIL 172 Query: 229 FGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREM--NP 286 G+TDY++ ID+W GC+ E+ G+P+FPG + +QL I ++LGTPT E + N Sbjct: 173 LGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNE 232 Query: 287 NYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDP 346 + + +P+ +A PR + L ++LL++ R++ +A H FF L + Sbjct: 233 EFKTYNYPKYRAEALLS-HAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLGER 291 Query: 347 NVKLPNGRDTPALFNFTTQELSSNPPLAT 375 KLP DT ++F +L L + Sbjct: 292 IHKLP---DTTSIFALKEIQLQKEASLRS 317 >4NST-A nrPDB Length = 351 Score = 285 bits (730), Expect = 2e-77, Method: Composition-based stats. Identities = 97/330 (29%), Positives = 155/330 (46%), Gaps = 32/330 (9%) Query: 54 VSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN------RELQIMRKLDHC 107 + +IG G++G VY+AK D+GELVA+KKV D + RE++I+R+L H Sbjct: 13 DKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHR 72 Query: 108 NIVRLRYFFYSSGE----KKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMY 163 ++V ++ + KKD+ LV +Y+ + + ++K +M Sbjct: 73 SVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLES---GLVHFSEDHIKSFMK 129 Query: 164 QLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGE--PNVSYICSRY 221 QL L Y H HRDIK N+LL+ ++ +KL DFG A+ E P + + + + Sbjct: 130 QLMEGLEYCHKKNFLHRDIKCSNILLN-NSGQIKLADFGLARLYNSEESRPYTNKVITLW 188 Query: 222 YRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQI 281 YR PEL+ G YT +IDVWS GC+L EL +PIF + + QL I ++ G+P Sbjct: 189 YRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVW 248 Query: 282 REMNPNYTEFKFPQIKAHPWTKVFRPRTPPE-------AIALCSRLLEYTPTARLTPLEA 334 ++ K P K +R R E A+ L +L P+ R T + Sbjct: 249 PDV------IKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQT 302 Query: 335 CAHSFFDEL---RDPNVKLPNGRDTPALFN 361 F ++ + LP+ +D L++ Sbjct: 303 LQSDFLKDVELSKMAPPDLPHWQDCHELWS 332 >5AWM-A nrPDB Length = 394 Score = 283 bits (724), Expect = 1e-76, Method: Composition-based stats. Identities = 89/313 (28%), Positives = 152/313 (48%), Gaps = 28/313 (8%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ------DKRFKNRELQIMRKLDHCN 108 Y + + IG+G+ G+V A + + VAIKK+ + + RE ++M+ ++H N Sbjct: 45 RYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKN 104 Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRS 168 I+ L F ++ + LV++ + + +V + L + +YQ+ Sbjct: 105 IIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQM------DLDHDRMSYLLYQMLCG 158 Query: 169 LAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELI 228 + ++HS GI HRD+KP N+++ D LK+ DFG A+ Y+ +RYYRAPE+I Sbjct: 159 IKHLHSAGIIHRDLKPSNIVVKADCT-LKILDFGLARTAGTTFMMTPYVVTRYYRAPEVI 217 Query: 229 FGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMN--- 285 G YT ++D+WS GC++ E++ G +FPG +DQ +II+ LGTP+ ++ + Sbjct: 218 LG-MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTV 276 Query: 286 -------PNYTEFK----FPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEA 334 P YT + FP R +A L S++L P R++ EA Sbjct: 277 RNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEA 336 Query: 335 CAHSFFDELRDPN 347 H + + D Sbjct: 337 LKHEYINVWYDAE 349 >1JNK-A nrPDB Length = 423 Score = 282 bits (721), Expect = 2e-76, Method: Composition-based stats. Identities = 91/312 (29%), Positives = 156/312 (50%), Gaps = 29/312 (9%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ------DKRFKNRELQIMRKLDHCN 108 Y + K IG+G+ G+V A VAIKK+ + + REL +M+ ++H N Sbjct: 63 RYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKN 122 Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRS 168 I+ L F ++ + LV++ + + +V + L + +YQ+ Sbjct: 123 IISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQM------ELDHERMSYLLYQMLCG 176 Query: 169 LAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELI 228 + ++HS GI HRD+KP N+++ D LK+ DFG A+ Y+ +RYYRAPE+I Sbjct: 177 IKHLHSAGIIHRDLKPSNIVVKSDCT-LKILDFGLARTAGTSFMMTPYVVTRYYRAPEVI 235 Query: 229 FGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNP-- 286 G Y ++D+WS GC++ E++ + +FPG +DQ ++I+ LGTP E ++++ P Sbjct: 236 LG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTV 294 Query: 287 -NYTEFKFPQIKAHPWTKVFRPRTPP-----------EAIALCSRLLEYTPTARLTPLEA 334 NY E + P+ + K+F P +A L S++L P R++ +A Sbjct: 295 RNYVENR-PKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDA 353 Query: 335 CAHSFFDELRDP 346 H + + DP Sbjct: 354 LQHPYINVWYDP 365 >3MA6-A nrPDB Length = 298 Score = 281 bits (720), Expect = 3e-76, Method: Composition-based stats. Identities = 90/335 (26%), Positives = 137/335 (40%), Gaps = 50/335 (14%) Query: 26 MKVSRDKDGSKVTTVVATPG---QGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELV 82 M + PG Q Y +V+G GSFG V K +G+ Sbjct: 1 MHHHHHHSSGRENLYFQGPGMFVQHSTAIFSDRYKGQRVLGKGSFGEVILCKDKITGQEC 60 Query: 83 AIKKVLQ-------DKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLD-Y 134 A+K + + DK RE+Q++++LDH NI++L FF G Y LV + Y Sbjct: 61 AVKVISKRQVKQKTDKESLLREVQLLKQLDHPNIMKLYEFFEDKG------YFYLVGEVY 114 Query: 135 VPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDT- 193 ++ R + + Q+ + Y+H I HRD+KP+NLLL+ + Sbjct: 115 TGGELFDEIISRKR----FSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLESKSK 170 Query: 194 -AVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL 252 A +++ DFG + + I + YY APE++ G Y DVWS G +L LL Sbjct: 171 DANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVLHGT--YDEKCDVWSTGVILYILLS 228 Query: 253 GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPE 312 G P F G + D L ++ K T F+ PQ W KV Sbjct: 229 GCPPFNGANEYDILKKVEKGKYT---------------FELPQ-----WKKV-----SES 263 Query: 313 AIALCSRLLEYTPTARLTPLEACAHSFFDELRDPN 347 A L ++L Y P+ R++ +A H + Sbjct: 264 AKDLIRKMLTYVPSMRISARDALDHEWIQTYTKEQ 298 >2XS0-A nrPDB Length = 386 Score = 281 bits (718), Expect = 5e-76, Method: Composition-based stats. Identities = 89/323 (27%), Positives = 157/323 (48%), Gaps = 27/323 (8%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ------DKRFKNRELQIMRKLDHCN 108 Y + K IG+G+ G+V A VAIKK+ + + REL +M+ ++H N Sbjct: 27 RYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKN 86 Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRS 168 I+ L F ++ + +V++ + + +V + L + +YQ+ Sbjct: 87 IIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQM------ELDHERMSYLLYQMLCG 140 Query: 169 LAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELI 228 + ++HS GI HRD+KP N+++ D LK+ DFG A+ V ++ +RYYRAPE+I Sbjct: 141 IKHLHSAGIIHRDLKPSNIVVKSDCT-LKILDFGLARTAGTSFMMVPFVVTRYYRAPEVI 199 Query: 229 FGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNY 288 G Y ++D+WS GC++ E++ G +FPG +DQ ++I+ LGTP E ++++ P Sbjct: 200 LG-MGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQPTV 258 Query: 289 TEF--KFPQIKAHPWTKVFRPRTPP-----------EAIALCSRLLEYTPTARLTPLEAC 335 + P+ + + K+F P +A L S++L + R++ EA Sbjct: 259 RTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEAL 318 Query: 336 AHSFFDELRDPNVKLPNGRDTPA 358 H + + DP+ P Sbjct: 319 QHPYINVWYDPSEAEAPPPKIPD 341 >3HZT-A nrPDB Length = 467 Score = 279 bits (714), Expect = 2e-75, Method: Composition-based stats. Identities = 80/297 (26%), Positives = 128/297 (43%), Gaps = 47/297 (15%) Query: 54 VSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNR-------ELQIMRKLDH 106 Y K +G+G++G V K +G AIK + + E+ ++++LDH Sbjct: 4 DRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDH 63 Query: 107 CNIVRLRYFFYSSGEKKDEVYLNLVLD-YVPETVYRVARHYSRAKQTLPVIYVKLYMYQL 165 NI++L FF +D+ LV++ Y ++ +Q + + M Q+ Sbjct: 64 PNIMKLYEFF------EDKRNYYLVMEVYRGGELFDEII----LRQKFSEVDAAVIMKQV 113 Query: 166 FRSLAYIHSFGICHRDIKPQNLLLDPDT--AVLKLCDFGSAKQLVRGEPNVSYICSRYYR 223 Y+H I HRD+KP+NLLL+ + A++K+ DFG + G + + YY Sbjct: 114 LSGTTYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYI 173 Query: 224 APELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIRE 283 APE++ Y DVWS G +L LL G P F G + + L + K Sbjct: 174 APEVL--RKKYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEK------------ 219 Query: 284 MNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF 340 +F F WT+V EA L +L Y P+ R++ EA H + Sbjct: 220 -----GKFSF---DPPDWTQV-----SDEAKQLVKLMLTYEPSKRISAEEALNHPWI 263 >1G3N-A nrPDB Length = 326 Score = 279 bits (713), Expect = 2e-75, Method: Composition-based stats. Identities = 93/321 (28%), Positives = 156/321 (48%), Gaps = 21/321 (6%) Query: 53 EVSYTDTKVIGNGSFGVVYQAKL-CDSGELVAIKKVLQDKRFKN------RELQIMRKLD 105 + Y IG G++G V++A+ + G VA+K+V + RE+ ++R L+ Sbjct: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLE 69 Query: 106 ---HCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYM 162 H N+VRL S + E L LV ++V + + + +P +K M Sbjct: 70 TFEHPNVVRLFDVCTVSRTDR-ETKLTLVFEHVDQDLTTYLDKV--PEPGVPTETIKDMM 126 Query: 163 YQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYY 222 +QL R L ++HS + HRD+KPQN+L+ + +KL DFG A+ S + + +Y Sbjct: 127 FQLLRGLDFLHSHRVVHRDLKPQNILVTS-SGQIKLADFGLARIYSFQMALTSVVVTLWY 185 Query: 223 RAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIR 282 RAPE++ ++ Y + +D+WS GC+ AE+ +P+F G S VDQL +I+ V+G P E Sbjct: 186 RAPEVLLQSS-YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWP 244 Query: 283 EMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDE 342 + F A P + F L + L + P R++ A +H +F + Sbjct: 245 R-DVALPRQAFHSKSAQP-IEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQD 302 Query: 343 L----RDPNVKLPNGRDTPAL 359 L + + LP ++T L Sbjct: 303 LERCKENLDSHLPPSQNTSEL 323 >3FI2-A nrPDB Length = 353 Score = 278 bits (711), Expect = 3e-75, Method: Composition-based stats. Identities = 90/327 (27%), Positives = 156/327 (47%), Gaps = 29/327 (8%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ------DKRFKNRELQIMRKLDHCN 108 Y + K IG+G+ G+V A VAIKK+ + + REL +M+ ++H N Sbjct: 25 RYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKN 84 Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRS 168 I+ L F ++ + LV++ + + +V + L + +YQ+ Sbjct: 85 IISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQM------ELDHERMSYLLYQMLCG 138 Query: 169 LAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELI 228 + ++HS GI HRD+KP N+++ D LK+ DFG A+ Y+ +RYYRAPE+I Sbjct: 139 IKHLHSAGIIHRDLKPSNIVVKSDCT-LKILDFGLARTAGTSFMMTPYVVTRYYRAPEVI 197 Query: 229 FGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNP-- 286 G Y ++D+WS GC++ E++ + +FPG +DQ ++I+ LGTP E ++++ P Sbjct: 198 LG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTV 256 Query: 287 -NYTEFKFPQIKAHPWTKVFRPRTPP-----------EAIALCSRLLEYTPTARLTPLEA 334 NY E + P+ + K+F P +A L S++L P R++ +A Sbjct: 257 RNYVENR-PKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDA 315 Query: 335 CAHSFFDELRDPNVKLPNGRDTPALFN 361 H + + T + Sbjct: 316 LQHPYINVWYXXXXXXDEREHTIEEWK 342 >2VN9-A nrPDB Length = 301 Score = 278 bits (711), Expect = 3e-75, Method: Composition-based stats. Identities = 85/333 (25%), Positives = 131/333 (39%), Gaps = 44/333 (13%) Query: 54 VSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVL------QDKRFKNRELQIMRKLDHC 107 Y + +G G+F VV + +G+ A K + +D + RE +I R L H Sbjct: 4 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 63 Query: 108 NIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFR 167 NIVRL G + LV D V A++ + Q+ Sbjct: 64 NIVRLHDSISEEG------FHYLVFDLVTGGELF---EDIVAREYYSEADASHCIQQILE 114 Query: 168 SLAYIHSFGICHRDIKPQNLLL--DPDTAVLKLCDFGSAKQLVRGEP-NVSYICSRYYRA 224 S+ + H GI HRD+KP+NLLL A +KL DFG A ++ + + + Y + Sbjct: 115 SVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLS 174 Query: 225 PELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREM 284 PE++ Y +D+W+ G +L LL+G P F D +L + IK Sbjct: 175 PEVLR-KDPYGKPVDMWACGVILYILLVGYPPF-WDEDQHRLYQQIKA------------ 220 Query: 285 NPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELR 344 + FP + W V PEA L +++L P R+T EA H + + Sbjct: 221 ----GAYDFPSPE---WDTV-----TPEAKDLINKMLTINPAKRITASEALKHPWICQRS 268 Query: 345 DPNVKLPNGRDTPALFNFTTQELSSNPPLATIL 377 + L F + L T+L Sbjct: 269 TVASMMHRQETVDCLKKFNARRKLKGAILTTML 301 >3E7O-A nrPDB Length = 360 Score = 278 bits (710), Expect = 5e-75, Method: Composition-based stats. Identities = 92/312 (29%), Positives = 151/312 (48%), Gaps = 29/312 (9%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ------DKRFKNRELQIMRKLDHCN 108 Y K IG+G+ G+V A G VA+KK+ + + REL +++ ++H N Sbjct: 23 RYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKN 82 Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRS 168 I+ L F ++ + LV++ + + +V L + +YQ+ Sbjct: 83 IISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHM------ELDHERMSYLLYQMLCG 136 Query: 169 LAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELI 228 + ++HS GI HRD+KP N+++ D LK+ DFG A+ Y+ +RYYRAPE+I Sbjct: 137 IKHLHSAGIIHRDLKPSNIVVKSDCT-LKILDFGLARTASTNFMMTPYVVTRYYRAPEVI 195 Query: 229 FGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNP-- 286 G Y ++D+WS GC++ EL+ G IF G +DQ ++I+ LGTP+ E + + P Sbjct: 196 LG-MGYKENVDIWSVGCIMGELVKGSVIFQGTDHIDQWNKVIEQLGTPSAEFMAALQPTV 254 Query: 287 -NYTEFKFPQIKAHPWTKVFRPRTPP-----------EAIALCSRLLEYTPTARLTPLEA 334 NY E + P + ++F P +A L S++L P R++ EA Sbjct: 255 RNYVENR-PAYPGIAFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEA 313 Query: 335 CAHSFFDELRDP 346 H + DP Sbjct: 314 LRHPYITVWYDP 325 >3DXN-A nrPDB Length = 287 Score = 277 bits (709), Expect = 6e-75, Method: Composition-based stats. Identities = 80/297 (26%), Positives = 128/297 (43%), Gaps = 47/297 (15%) Query: 54 VSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNR-------ELQIMRKLDH 106 Y K +G+G++G V K +G AIK + + E+ ++++LDH Sbjct: 21 DRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDH 80 Query: 107 CNIVRLRYFFYSSGEKKDEVYLNLVLD-YVPETVYRVARHYSRAKQTLPVIYVKLYMYQL 165 NI++L FF +D+ LV++ Y ++ +Q + + M Q+ Sbjct: 81 PNIMKLYEFF------EDKRNYYLVMEVYRGGELFDEII----LRQKFSEVDAAVIMKQV 130 Query: 166 FRSLAYIHSFGICHRDIKPQNLLLDPDT--AVLKLCDFGSAKQLVRGEPNVSYICSRYYR 223 Y+H I HRD+KP+NLLL+ + A++K+ DFG + G + + YY Sbjct: 131 LSGTTYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYI 190 Query: 224 APELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIRE 283 APE++ Y DVWS G +L LL G P F G + + L + K Sbjct: 191 APEVL--RKKYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEK------------ 236 Query: 284 MNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF 340 +F F WT+V EA L +L Y P+ R++ EA H + Sbjct: 237 -----GKFSF---DPPDWTQV-----SDEAKQLVKLMLTYEPSKRISAEEALNHPWI 280 >4BGQ-A nrPDB Length = 304 Score = 277 bits (708), Expect = 7e-75, Method: Composition-based stats. Identities = 105/300 (35%), Positives = 154/300 (51%), Gaps = 22/300 (7%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQD------KRFKNRELQIMRKLDHCNI 109 + V+G G++GVV + + ++ E+VAIKK K REL+++R L NI Sbjct: 14 FEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENI 73 Query: 110 VRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 169 V L+ F G+ L LV +YV + + + +P VK Y+YQL +++ Sbjct: 74 VELKEAFRRRGK------LYLVFEYVEKNMLELLE---EMPNGVPPEKVKSYIYQLIKAI 124 Query: 170 AYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEP--NVSYICSRYYRAPEL 227 + H I HRDIKP+NLL+ + VLKLCDFG A+ L G + +R+YR+PEL Sbjct: 125 HWCHKNDIVHRDIKPENLLISHND-VLKLCDFGFARNLSEGNNANYDEEVATRWYRSPEL 183 Query: 228 IFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREM--N 285 + GA Y S+D+WS GC+L EL GQP+FPG+S +DQL I KVLG EQ++ N Sbjct: 184 LLGA-PYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSN 242 Query: 286 PNYTEFKFPQIK-AHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELR 344 P + +FP + + + + L LL+ P R + H F R Sbjct: 243 PRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQR 302 >3ZDU-A nrPDB Length = 325 Score = 276 bits (707), Expect = 9e-75, Method: Composition-based stats. Identities = 83/293 (28%), Positives = 149/293 (50%), Gaps = 18/293 (6%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQD-----KRFKNRELQIMRKLDHCNIV 110 Y +G GS+G V + K ++G++VAIK + + RE++ +++ H N+V Sbjct: 5 YETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQFHHENLV 64 Query: 111 RLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLA 170 L F + + ++LV +++ TV +HY L ++ Y++Q+ R++ Sbjct: 65 NLIEVF------RQKKKIHLVFEFIDHTVLDELQHYCHG---LESKRLRKYLFQILRAID 115 Query: 171 YIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLV-RGEPNVSYICSRYYRAPELIF 229 Y+HS I HRDIKP+N+L+ + + KLCDFG A+ L G+ + +R+YRAPEL+ Sbjct: 116 YLHSNNIIHRDIKPENILVSQ-SGITKLCDFGFARTLAAPGDIYDDEVATRWYRAPELVL 174 Query: 230 GATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLG--TPTREQIREMNPN 287 T Y +D+W+ GC++ E+ G P P S +D L +I+ +G +P + I +P Sbjct: 175 KDTSYGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPI 234 Query: 288 YTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF 340 + PQ++ + P+ + L+ P R++ + H +F Sbjct: 235 FAGVVLPQVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYF 287 >3PG1-A nrPDB Length = 362 Score = 276 bits (707), Expect = 1e-74, Method: Composition-based stats. Identities = 93/328 (28%), Positives = 154/328 (46%), Gaps = 29/328 (8%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQD---------------KRFKNRELQI 100 YT + I +GS+G V + G VAIK+V + RE+++ Sbjct: 24 YTVQRFISSGSYGAVCAGVDSE-GIPVAIKRVFNTVSDGRTVNILSDSFLCKRVLREIRL 82 Query: 101 MRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKL 160 + H NI+ LR F E L LV + + + +V + + +++ Sbjct: 83 LNHFHHPNILGLRDIFVHFEEPAMHK-LYLVTELMRTDLAQVIHD---QRIVISPQHIQY 138 Query: 161 YMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSR 220 +MY + L +H G+ HRD+ P N+LL D + +CDF A++ Y+ R Sbjct: 139 FMYHILLGLHVLHEAGVVHRDLHPGNILL-ADNNDITICDFNLAREDTADANKTHYVTHR 197 Query: 221 YYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQ 280 +YRAPEL+ +T +D+WSAGCV+AE+ + +F G + +QL +I++V+GTP E Sbjct: 198 WYRAPELVMQFKGFTKLVDMWSAGCVMAEMFNRKALFRGSTFYNQLNKIVEVVGTPKIED 257 Query: 281 IREMNP----NYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACA 336 + + +Y + A WT V P P A+ L +++LE+ P R++ +A Sbjct: 258 VVMFSSPSARDYLRNSLSNVPARAWTAVV-PTADPVALDLIAKMLEFNPQRRISTEQALR 316 Query: 337 HSFFDELRDPNVKLPNGRDTPALFNFTT 364 H +F+ L DP L F+F Sbjct: 317 HPYFESLFDP---LDLTEGLSERFHFDE 341 >3LIJ-A nrPDB Length = 494 Score = 275 bits (704), Expect = 2e-74, Method: Composition-based stats. Identities = 82/353 (23%), Positives = 147/353 (41%), Gaps = 55/353 (15%) Query: 42 ATPGQG----PDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ------DK 91 ATPG E+ Y K +G+G++G V + + AIK + + Sbjct: 22 ATPGMFITSKKGHLSEM-YQRVKKLGSGAYGEVLLCRDKVTHVERAIKIIRKTSVSTSSN 80 Query: 92 RFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLD-YVPETVYRVARHYSRAK 150 E+ +++ LDH NI++L FF +D+ LV++ Y ++ H + Sbjct: 81 SKLLEEVAVLKLLDHPNIMKLYDFF------EDKRNYYLVMECYKGGELFDEIIHRMK-- 132 Query: 151 QTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLD--PDTAVLKLCDFGSAKQLV 208 + + + Q+ + Y+H I HRD+KP+NLLL+ A++K+ DFG + Sbjct: 133 --FNEVDAAVIIKQVLSGVTYLHKHNIVHRDLKPENLLLESKEKDALIKIVDFGLSAVFE 190 Query: 209 RGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVE 268 + + + YY APE++ Y DVWS G +L LL G P F G + + L + Sbjct: 191 NQKKMKERLGTAYYIAPEVL--RKKYDEKCDVWSIGVILFILLAGYPPFGGQTDQEILRK 248 Query: 269 IIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTAR 328 + K T F P+ W V A L ++L++ R Sbjct: 249 VEKGKYT---------------FDSPE-----WKNV-----SEGAKDLIKQMLQFDSQRR 283 Query: 329 LTPLEACAHSFFDEL---RDPNVKLPNGRD-TPALFNFTTQELSSNPPLATIL 377 ++ +A H + E+ ++ ++LP+ + + F + + L + Sbjct: 284 ISAQQALEHPWIKEMCSKKESGIELPSLANAIENMRKFQNSQKLAQAALLYMA 336 >3NCG-A nrPDB Length = 486 Score = 274 bits (702), Expect = 4e-74, Method: Composition-based stats. Identities = 79/319 (24%), Positives = 131/319 (41%), Gaps = 47/319 (14%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ------DKRFKNRELQIMRKLDHCN 108 Y ++G GSFG V + K + + A+K + + D RE+++++KLDH N Sbjct: 23 RYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLDHPN 82 Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRS 168 I++L E Y+ L E + + + + Q+F Sbjct: 83 IMKLFEIL----EDSSSFYIVGELYTGGELFDEIIKR-----KRFSEHDAARIIKQVFSG 133 Query: 169 LAYIHSFGICHRDIKPQNLLLD--PDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPE 226 + Y+H I HRD+KP+N+LL+ +K+ DFG + + I + YY APE Sbjct: 134 ITYMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPE 193 Query: 227 LIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNP 286 ++ G Y DVWSAG +L LL G P F G + D L + + Sbjct: 194 VLRGT--YDEKCDVWSAGVILYILLSGTPPFYGKNEYDIL---------------KRVET 236 Query: 287 NYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDP 346 F PQ + +A L ++L + P+ R+T + H + + Sbjct: 237 GKYAFDLPQWRT----------ISDDAKDLIRKMLTFHPSLRITATQCLEHPWIQKY--- 283 Query: 347 NVKLPNGRDTPALFNFTTQ 365 + + P D P+L + T Sbjct: 284 SSETPTISDLPSLESAMTN 302 >3GC0-A nrPDB Length = 329 Score = 274 bits (700), Expect = 6e-74, Method: Composition-based stats. Identities = 93/328 (28%), Positives = 159/328 (48%), Gaps = 28/328 (8%) Query: 28 VSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKV 87 + G +V A P Y +G G++G VY+A + E VAIK++ Sbjct: 12 LEAQTQGPGSMSVSAAPSATS----IDRYRRITKLGEGTYGEVYKAIDTVTNETVAIKRI 67 Query: 88 LQDKRFKN------RELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYR 141 + + RE+ ++++L H NI+ L+ + + L+L+ +Y + Sbjct: 68 RLEHEEEGVPGTAIREVSLLKELQHRNIIELKSVIHHNHR------LHLIFEYAENDL-- 119 Query: 142 VARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLD----PDTAVLK 197 + Y + + +K ++YQL + + HS HRD+KPQNLLL +T VLK Sbjct: 120 --KKYMDKNPDVSMRVIKSFLYQLINGVNFCHSRRCLHRDLKPQNLLLSVSDASETPVLK 177 Query: 198 LCDFGSAKQL-VRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPI 256 + DFG A+ + I + +YR PE++ G+ Y++S+D+WS C+ AE+L+ P+ Sbjct: 178 IGDFGLARAFGIPIRQFTHEIITLWYRPPEILLGSRHYSTSVDIWSIACIWAEMLMKTPL 237 Query: 257 FPGDSGVDQLVEIIKVLGTPTREQIREMN--PNYTEFKFPQIKAHPWTKVFRPRTPPEAI 314 FPGDS +DQL +I +VLG P + P++ + FP+ + +V E + Sbjct: 238 FPGDSEIDQLFKIFEVLGLPDDTTWPGVTALPDWKQ-SFPKFRGKTLKRVLGALLDDEGL 296 Query: 315 ALCSRLLEYTPTARLTPLEACAHSFFDE 342 L + +LE P R++ A H +F Sbjct: 297 DLLTAMLEMDPVKRISAKNALEHPYFSH 324 >4O2Z-A nrPDB Length = 377 Score = 272 bits (696), Expect = 2e-73, Method: Composition-based stats. Identities = 92/353 (26%), Positives = 162/353 (45%), Gaps = 20/353 (5%) Query: 24 GSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVA 83 + V + KV V +P + P + YT K++G G++G+ D+GE V+ Sbjct: 20 QELSVPKIVGDFKVYNVSGSPFEVPSK-----YTLLKILGMGAYGIACSCLDGDTGEKVS 74 Query: 84 IKKVL------QDKRFKNRELQIMRKLDHCNIVRLRYFFYS-SGEKKDEVYLNLVLDYVP 136 IKK +D + RE+ +MR H N++ + E + +V + Sbjct: 75 IKKCRDVFRDVEDGKRVLREIDMMRFFHHENLLNVVNILPPLKREYHSFEDVYVVTPLMD 134 Query: 137 ETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVL 196 + V R++Q L +++ ++YQ+ R L Y+HS + HRD+KP N L+ + L Sbjct: 135 VDMNVVL----RSRQVLEESHMQYFVYQILRGLKYLHSANVAHRDLKPAN-LVTNISCEL 189 Query: 197 KLCDFGSAKQL-VRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQP 255 K+ DFG ++ + V Y+ +R+YR PEL+ T+Y++++D+WS GC+ AE+ +P Sbjct: 190 KIIDFGLSRSVDVPYSELTDYVITRWYRPPELLLENTNYSTAVDIWSVGCIFAEMYNRKP 249 Query: 256 IFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIA 315 +FPG + +DQL I + +G P + + P + V E I Sbjct: 250 VFPGRNTMDQLRMIAQHIGKPPASIVEHREALEKLNELPDGSLNIPKLVPGLAGNTEGID 309 Query: 316 LCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELS 368 S++ P+ R T + AH + L D + P L+ + + Sbjct: 310 FLSKMWTLDPSKRPTAADMLAHPYLAHLHDEEDEPTC--PCPFLWAHESTPMG 360 >2V7O-A nrPDB Length = 336 Score = 272 bits (695), Expect = 2e-73, Method: Composition-based stats. Identities = 83/340 (24%), Positives = 133/340 (39%), Gaps = 44/340 (12%) Query: 54 VSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVL------QDKRFKNRELQIMRKLDHC 107 Y + +G G+F VV + + A K + +D + RE +I R L H Sbjct: 31 DDYQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 90 Query: 108 NIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFR 167 NIVRL G + LV D V A++ ++Q+ Sbjct: 91 NIVRLHDSISEEG------FHYLVFDLVTGGELF---EDIVAREYYSEADASHCIHQILE 141 Query: 168 SLAYIHSFGICHRDIKPQNLLLDPD--TAVLKLCDFGSAKQLVRGEP-NVSYICSRYYRA 224 S+ +IH I HRD+KP+NLLL A +KL DFG A ++ + + + Y + Sbjct: 142 SVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLS 201 Query: 225 PELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREM 284 PE++ Y +D+W+ G +L LL+G P F D +L + IK Sbjct: 202 PEVLR-KDPYGKPVDIWACGVILYILLVGYPPF-WDEDQHKLYQQIKA------------ 247 Query: 285 NPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELR 344 + FP + W V PEA L +++L P R+T +A H + + Sbjct: 248 ----GAYDFPSPE---WDTV-----TPEAKNLINQMLTINPAKRITADQALKHPWVCQRS 295 Query: 345 DPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARI 384 + L F + L T+L+ + + Sbjct: 296 TVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSV 335 >3MIA-A nrPDB Length = 351 Score = 271 bits (693), Expect = 4e-73, Method: Composition-based stats. Identities = 92/326 (28%), Positives = 144/326 (44%), Gaps = 22/326 (6%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFK------NRELQIMRKLDHCNI 109 Y IG G+FG V++A+ +G+ VA+KKVL + + RE++I++ L H N+ Sbjct: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 Query: 110 VRLRYFFYSSGEKKDEVY--LNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFR 167 V L + + + LV D+ + + + + +K M L Sbjct: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVL---VKFTLSEIKRVMQMLLN 135 Query: 168 SLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLV-----RGEPNVSYICSRYY 222 L YIH I HRD+K N+L+ D VLKL DFG A+ + + + + +Y Sbjct: 136 GLYYIHRNKILHRDMKAANVLITRD-GVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWY 194 Query: 223 RAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIR 282 R PEL+ G DY ID+W AGC++AE+ PI G++ QL I ++ G+ T E Sbjct: 195 RPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWP 254 Query: 283 EMNPNYTEFKFPQIKAHPWTKVFRPRT---PPEAIALCSRLLEYTPTARLTPLEACAHSF 339 ++ K +K R + P A+ L +LL P R+ +A H F Sbjct: 255 NVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDF 314 Query: 340 FDELRDPNVKLPNGRDTPALFNFTTQ 365 F DP G + L + Sbjct: 315 F--WSDPMPSDLKGMLSTHLTSMFEY 338 >5U6Y-A nrPDB Length = 461 Score = 271 bits (692), Expect = 5e-73, Method: Composition-based stats. Identities = 86/363 (23%), Positives = 138/363 (38%), Gaps = 49/363 (13%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVL------QDKRFKNRELQIMRKLDHCNI 109 Y + +G G+F VV + +G+ A K + +D + RE +I R L H NI Sbjct: 2 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 61 Query: 110 VRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 169 VRL G + L+ D V A++ + Q+ ++ Sbjct: 62 VRLHDSISEEG------HHYLIFDLVTGGELF---EDIVAREYYSEADASHCIQQILEAV 112 Query: 170 AYIHSFGICHRDIKPQNLLLDPD--TAVLKLCDFGSAKQLVRGEP-NVSYICSRYYRAPE 226 + H G+ HRD+KP+NLLL A +KL DFG A ++ + + + Y +PE Sbjct: 113 LHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPE 172 Query: 227 LIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNP 286 ++ Y +D+W+ G +L LL+G P F D +L + IK Sbjct: 173 VLR-KDPYGKPVDLWACGVILYILLVGYPPF-WDEDQHRLYQQIKA-------------- 216 Query: 287 NYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDP 346 + FP + W V PEA L +++L P+ R+T EA H + Sbjct: 217 --GAYDFPSPE---WDTV-----TPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTV 266 Query: 347 NVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASPPANATAASDTNAGDRG 406 + L F + L T+L + + + SD Sbjct: 267 ASCMHRQETVDCLKKFNARRKLKGAILTTMLATRNF-----SGGKSGGNKKSDGVKESSE 321 Query: 407 QTN 409 TN Sbjct: 322 STN 324 >3DFA-A nrPDB Length = 286 Score = 270 bits (690), Expect = 9e-73, Method: Composition-based stats. Identities = 74/297 (24%), Positives = 122/297 (41%), Gaps = 44/297 (14%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ------DKRFKNRELQIMRKLDHCN 108 Y ++G GSFG V + K + + A+K + + D RE+++++KLDH N Sbjct: 23 RYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLDHPN 82 Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRS 168 I++L E Y+ L E + + + + Q+F Sbjct: 83 IMKLFEIL----EDSSSFYIVGELYTGGELFDEIIKR-----KRFSEHDAARIIKQVFSG 133 Query: 169 LAYIHSFGICHRDIKPQNLLLD--PDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPE 226 + Y+H I HRD+KP+N+LL+ +K+ DFG + + I + YY APE Sbjct: 134 ITYMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPE 193 Query: 227 LIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNP 286 ++ G Y DVWSAG +L LL G P F G + D L + + Sbjct: 194 VLRGT--YDEKCDVWSAGVILYILLSGTPPFYGKNEYDIL---------------KRVET 236 Query: 287 NYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDEL 343 F PQ + +A L ++L + P+ R+T + H + + Sbjct: 237 GKYAFDLPQWRT----------ISDDAKDLIRKMLTFHPSLRITATQCLEHPWIQKY 283 >3RP9-A nrPDB Length = 458 Score = 269 bits (688), Expect = 1e-72, Method: Composition-based stats. Identities = 123/444 (27%), Positives = 181/444 (40%), Gaps = 84/444 (18%) Query: 24 GSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVA 83 K + + Q PDR Y +IG GS+G V +A +VA Sbjct: 28 QQRKQHHSSKPTASMPRPHSDWQIPDR-----YEIRHLIGTGSYGHVCEAYDKLEKRVVA 82 Query: 84 IKKVLQ------DKRFKNRELQIMRKLDHCNIVRLRYFFYSSG-EKKDEVYLNLVLDYVP 136 IKK+L+ D + RE+ I+ +L+H ++V++ EK DE+Y+ L Sbjct: 83 IKKILRVFEDLIDCKRILREIAILNRLNHDHVVKVLDIVIPKDVEKFDELYVVL------ 136 Query: 137 ETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVL 196 E + R L +++K +Y L + Y+HS GI HRD+KP N L++ D +V Sbjct: 137 EIADSDFKKLFRTPVYLTELHIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQDCSV- 195 Query: 197 KLCDFGSAKQLVRGEP----------------------------NVSYICSRYYRAPELI 228 K+CDFG A+ + E ++ +R+YRAPELI Sbjct: 196 KVCDFGLARTVDYPENGNSQLPISPREDDMNLVTFPHTKNLKRQLTGHVVTRWYRAPELI 255 Query: 229 FGATDYTSSIDVWSAGCVLAELLL-----------GQPIFPGDS---------------- 261 +YT +IDVWS GC+ AELL P+FPG S Sbjct: 256 LLQENYTEAIDVWSIGCIFAELLNMIKENVAYHADRGPLFPGSSCFPLSPDQKAGNDFKF 315 Query: 262 ----GVDQLVEIIKVLGTPTREQIREMNPNYTEFK---FPQIKAHPWTKVFRPRTPPEAI 314 DQL I +LGTP+ E I + + FP+ + + F P + +AI Sbjct: 316 HTRGNRDQLNVIFNILGTPSEEDIEALEKEDAKRYIRIFPKREGTDLAERF-PASSADAI 374 Query: 315 ALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFN--FTTQELSSNPP 372 L R+L + P R+T E AH FF E+R V+ FN E Sbjct: 375 HLLKRMLVFNPNKRITINECLAHPFFKEVRIAEVETNATEKVRLPFNDWMNMDEPQLRYA 434 Query: 373 LATILIPPHARIQAAASPPANATA 396 + H IQ P A++ Sbjct: 435 FVKEIQRYHPEIQLPRRSPNRASS 458 >4RGJ-A nrPDB Length = 520 Score = 269 bits (687), Expect = 2e-72, Method: Composition-based stats. Identities = 88/371 (23%), Positives = 152/371 (40%), Gaps = 55/371 (14%) Query: 21 SAFGSMKVSRDKDGSKVTTVVATPG---QGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCD 77 S+ +S+ + PG Q + Y K++G GSFG V ++ Sbjct: 24 MKESSVGISKKIVENSFNNSKLRPGMFIQNSNVVFNEQYKGIKILGKGSFGEVILSRDKH 83 Query: 78 SGELVAIKKVLQ-------DKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNL 130 +G AIK + + DK RE+++++ LDH NI++L FF +D Y L Sbjct: 84 TGHEYAIKVISKKHVKRKTDKESLLREVELLKMLDHINIMKLYEFF------EDNNYYYL 137 Query: 131 VLD-YVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLL 189 V D Y ++ R I + Q+ + Y+H + HRD+KP+N+LL Sbjct: 138 VSDVYTGGELFDEIISRKR----FYEIDAARIIKQILSGITYMHKNNVVHRDLKPENILL 193 Query: 190 ---DPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCV 246 + + ++K+ DFG + + I + YY AP+++ G Y D+WS G + Sbjct: 194 ETKNKEDMIIKIIDFGLSTHFEYSKKMKDKIGTAYYIAPDVLHGT--YDEKCDIWSCGVI 251 Query: 247 LAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFR 306 L LL G P F G + D L +++ F PQ K Sbjct: 252 LYILLSGCPPFNGSNEYDIL---------------KKVEAGKYTFDLPQFK--------- 287 Query: 307 PRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELR---DPNVKLPNGR-DTPALFNF 362 + +A L ++L YT R++ +A H + + + N+ +P+ + F Sbjct: 288 -KISDKAKDLIKKMLMYTSAVRISARDALEHEWIKMMTSKDNLNIDIPSLELSIANIRQF 346 Query: 363 TTQELSSNPPL 373 + + + L Sbjct: 347 QSTQKLAQAAL 357 >2I6L-A nrPDB Length = 320 Score = 268 bits (686), Expect = 2e-72, Method: Composition-based stats. Identities = 93/311 (29%), Positives = 158/311 (50%), Gaps = 26/311 (8%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKV----LQDKRFKNRELQIMRKLDHCNIV 110 Y D K +G G G+V+ A D + VAIKK+ Q + RE++I+R+LDH NIV Sbjct: 12 RYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHALREIKIIRRLDHDNIV 71 Query: 111 RLRYFFYSSGEKKDEVY--------LNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYM 162 ++ SG + + + +V +Y+ + V + L + +L+M Sbjct: 72 KVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLE-----QGPLLEEHARLFM 126 Query: 163 YQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSY----IC 218 YQL R L YIHS + HRD+KP NL ++ + VLK+ DFG A+ + + + + Sbjct: 127 YQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLV 186 Query: 219 SRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIK---VLGT 275 +++YR+P L+ +YT +ID+W+AGC+ AE+L G+ +F G ++Q+ I++ V+ Sbjct: 187 TKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHE 246 Query: 276 PTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEAC 335 R+++ + P Y + H P EA+ ++L ++P RLT EA Sbjct: 247 EDRQELLSVIPVYIRNDMTEP--HKPLTQLLPGISREAVDFLEQILTFSPMDRLTAEEAL 304 Query: 336 AHSFFDELRDP 346 +H + P Sbjct: 305 SHPYMSIYSFP 315 >2BDW-A nrPDB Length = 362 Score = 268 bits (686), Expect = 2e-72, Method: Composition-based stats. Identities = 88/369 (23%), Positives = 143/369 (38%), Gaps = 50/369 (13%) Query: 49 DRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVL------QDKRFKNRELQIMR 102 +Y + +G G+F VV + +G A K + +D + RE +I R Sbjct: 24 STKFSDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICR 83 Query: 103 KLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYM 162 KL H NIVRL ++E + LV D V A++ + Sbjct: 84 KLQHPNIVRLHDSI------QEESFHYLVFDLVTGGELF---EDIVAREFYSEADASHCI 134 Query: 163 YQLFRSLAYIHSFGICHRDIKPQNLLL--DPDTAVLKLCDFGSAKQLVRGEPNVSYICSR 220 Q+ S+AY HS GI HR++KP+NLLL A +KL DFG A ++ E + + Sbjct: 135 QQILESIAYCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTP 194 Query: 221 YYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQ 280 Y +PE++ Y+ +D+W+ G +L LL+G P F D +L IK Sbjct: 195 GYLSPEVL-KKDPYSKPVDIWACGVILYILLVGYPPF-WDEDQHRLYAQIKA-------- 244 Query: 281 IREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF 340 + +P + W V PEA +L +L P R+T +A + Sbjct: 245 --------GAYDYPSPE---WDTV-----TPEAKSLIDSMLTVNPKKRITADQALKVPWI 288 Query: 341 DELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHAR-------IQAAASPPAN 393 + L F + L T++ + + PP+ Sbjct: 289 CNRERVASAIHRQDTVDCLKKFNARRKLKGAILTTMIATRNLSNLGRNLLNKKEQGPPST 348 Query: 394 ATAASDTNA 402 +S+++ Sbjct: 349 IKESSESSQ 357 >4YZB-A nrPDB Length = 491 Score = 266 bits (681), Expect = 9e-72, Method: Composition-based stats. Identities = 91/321 (28%), Positives = 138/321 (42%), Gaps = 50/321 (15%) Query: 34 GSKVTTVVATPG---QGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQD 90 SK + ATPG Q Y +V+G GSFG V K +G+ A+K + + Sbjct: 7 ASKSDKLAATPGMFVQHSTAAFSDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKR 66 Query: 91 KRFKNRE-------LQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLD-YVPETVYRV 142 + + + +++++KLDH NI++L FF G Y LV + Y ++ Sbjct: 67 QVKQKTDKELLLKEVELLKKLDHPNIMKLYEFFEDKG------YFYLVTEVYTGGELFDE 120 Query: 143 ARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDT--AVLKLCD 200 R + + Q+ + Y+H I HRD+KP+NLLL+ A +++ D Sbjct: 121 IISRKR----FSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLENKRKDANIRIID 176 Query: 201 FGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGD 260 FG + + I + YY APE++ G Y DVWS G +L LL G P F G Sbjct: 177 FGLSTHFESTKKMKDKIGTAYYIAPEVLHGT--YDEKCDVWSTGVILYILLSGCPPFNGA 234 Query: 261 SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRL 320 + D L ++ K T F PQ W KV P A L ++ Sbjct: 235 NEFDILKKVEKGKFT---------------FDLPQ-----WKKVSEP-----AKDLIRKM 269 Query: 321 LEYTPTARLTPLEACAHSFFD 341 L Y PT R++ +A H + Sbjct: 270 LAYVPTMRISARDALEHEWLK 290 >3Q5I-A nrPDB Length = 504 Score = 265 bits (678), Expect = 2e-71, Method: Composition-based stats. Identities = 85/362 (23%), Positives = 138/362 (38%), Gaps = 62/362 (17%) Query: 40 VVATPGQGPDRPQE---VSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNR 96 + PG + + SY + +G+G++G V K + AIK + + + K R Sbjct: 19 IAINPGMYVRKKEGKIGESYFKVRKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGR 78 Query: 97 -----------------ELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDY--VPE 137 E+ +++ LDH NI++L F +D+ Y LV ++ E Sbjct: 79 YSDDNKNIEKFHEEIYNEISLLKSLDHPNIIKLFDVF------EDKKYFYLVTEFYEGGE 132 Query: 138 TVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAV-- 195 ++ + M Q+ + Y+H I HRDIKP+N+LL+ ++ Sbjct: 133 LFEQIINRHK-----FDECDAANIMKQILSGICYLHKHNIVHRDIKPENILLENKNSLLN 187 Query: 196 LKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQP 255 +K+ DFG + + + + YY APE++ Y DVWS G ++ LL G P Sbjct: 188 IKIVDFGLSSFFSKDYKLRDRLGTAYYIAPEVL--KKKYNEKCDVWSCGVIMYILLCGYP 245 Query: 256 IFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIA 315 F G + D + ++ K F F + W + EA Sbjct: 246 PFGGQNDQDIIKKVEK---------------GKYYFDF-----NDWKNI-----SDEAKE 280 Query: 316 LCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLAT 375 L +L Y R T EA + + + K AL N E S A Sbjct: 281 LIKLMLTYDYNKRCTAEEALNSRWIKKYANNINKSDQKTLCGALSNMRKFEGSQKLAQAA 340 Query: 376 IL 377 IL Sbjct: 341 IL 342 >5XZW-A nrPDB Length = 471 Score = 264 bits (674), Expect = 7e-71, Method: Composition-based stats. Identities = 90/346 (26%), Positives = 147/346 (42%), Gaps = 62/346 (17%) Query: 23 FGSMKVSRDKDGSKVTTVVATPGQGPDRPQEV---------SYTDT-KVIGNGSFGVVYQ 72 KV R + K T+ +A+PG + ++ +V+G G+F V + Sbjct: 155 LEQNKVDRIRSNLKNTSKIASPGLTSSTASSMVANKTGIFKDFSIIDEVVGQGAFATVKK 214 Query: 73 AKLCDSGELVAIKKVLQDKRFKN-----RELQIMRKLDHCNIVRLRYFFYSSGEKKDEVY 127 A +G+ A+K + + K N REL++++KL+H IVRL+ F+ +D Sbjct: 215 AIERTTGKTFAVKIISKRKVIGNMDGVTRELEVLQKLNHPRIVRLKGFY------EDTES 268 Query: 128 LNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNL 187 +V+++V + A + + Q+ ++ YIHS GI HRD+KP N+ Sbjct: 269 YYMVMEFVSGG---DLMDFVAAHGAVGEDAGREISRQILTAIKYIHSMGISHRDLKPDNI 325 Query: 188 LLDPDTAVL-KLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFG------------ATDY 234 L++ D VL K+ DFG AK G ++ + Y APE+I G +Y Sbjct: 326 LIEQDDPVLVKITDFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSPDEYEERNEY 385 Query: 235 TSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFP 294 +S +D+WS GC++ +L G F G S DQL + I + Sbjct: 386 SSLVDMWSMGCLVYVILTGHLPFSG-STQDQLYKQI------------------GRGSYH 426 Query: 295 QIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF 340 + + R EA LL+ P R T +A H + Sbjct: 427 EGPLKDF------RISEEARDFIDSLLQVDPNNRSTAAKALNHPWI 466 >2VZ6-A nrPDB Length = 313 Score = 263 bits (673), Expect = 7e-71, Method: Composition-based stats. Identities = 79/325 (24%), Positives = 127/325 (39%), Gaps = 44/325 (13%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVL------QDKRFKNRELQIMRKLDHCNI 109 Y + +G G+F VV + +G+ A K + +D + RE +I R L H NI Sbjct: 24 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 83 Query: 110 VRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 169 VRL G + L+ D V A++ + Q+ ++ Sbjct: 84 VRLHDSISEEG------HHYLIFDLVTGGELF---EDIVAREYYSEADASHCIQQILEAV 134 Query: 170 AYIHSFGICHRDIKPQNLLLDPD--TAVLKLCDFGSAKQLVRGEP-NVSYICSRYYRAPE 226 + H G+ HRD+KP+NLLL A +KL DFG A ++ + + + Y +PE Sbjct: 135 LHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPE 194 Query: 227 LIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNP 286 ++ Y +D+W+ G +L LL+G P F D +L + IK Sbjct: 195 VLR-KDPYGKPVDLWACGVILYILLVGYPPF-WDEDQHRLYQQIKA-------------- 238 Query: 287 NYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDP 346 + FP + W V PEA L +++L P+ R+T EA H + Sbjct: 239 --GAYDFPSPE---WDTV-----TPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTV 288 Query: 347 NVKLPNGRDTPALFNFTTQELSSNP 371 + L F + Sbjct: 289 ASCMHRQETVDCLKKFNARRKLKGA 313 >3BHH-A nrPDB Length = 295 Score = 263 bits (673), Expect = 8e-71, Method: Composition-based stats. Identities = 81/327 (24%), Positives = 126/327 (38%), Gaps = 44/327 (13%) Query: 54 VSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVL------QDKRFKNRELQIMRKLDHC 107 Y + IG G+F VV + +G A K + +D + RE +I R L H Sbjct: 4 DEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHS 63 Query: 108 NIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFR 167 NIVRL G + LV D V A++ + Q+ Sbjct: 64 NIVRLHDSISEEG------FHYLVFDLVTGGELF---EDIVAREYYSEADASHCIQQILE 114 Query: 168 SLAYIHSFGICHRDIKPQNLLLDPD--TAVLKLCDFGSAKQLVRGEP-NVSYICSRYYRA 224 ++ + H G+ HRD+KP+NLLL A +KL DFG A ++ + + + Y + Sbjct: 115 AVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLS 174 Query: 225 PELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREM 284 PE++ Y +D+W+ G +L LL+G P F D +L + IK Sbjct: 175 PEVLR-KEAYGKPVDIWACGVILYILLVGYPPF-WDEDQHKLYQQIKA------------ 220 Query: 285 NPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELR 344 + FP + W V PEA L +++L P R+T EA H + + Sbjct: 221 ----GAYDFPSPE---WDTV-----TPEAKNLINQMLTINPAKRITAHEALKHPWVCQRS 268 Query: 345 DPNVKLPNGRDTPALFNFTTQELSSNP 371 + L F + Sbjct: 269 TVASMMHRQETVECLKKFNARRKLKGA 295 >3SOA-A nrPDB Length = 444 Score = 262 bits (670), Expect = 2e-70, Method: Composition-based stats. Identities = 79/339 (23%), Positives = 131/339 (38%), Gaps = 44/339 (12%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVL------QDKRFKNRELQIMRKLDHCN 108 Y + +G G+F VV + +G+ A + +D + RE +I R L H N Sbjct: 12 EYQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDHQKLEREARICRLLKHPN 71 Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRS 168 IVRL G + L+ D V A++ + Q+ + Sbjct: 72 IVRLHDSISEEG------HHYLIFDLVTGGELF---EDIVAREYYSEADASHCIQQILEA 122 Query: 169 LAYIHSFGICHRDIKPQNLLLDPD--TAVLKLCDFGSAKQLVRGEP-NVSYICSRYYRAP 225 + + H G+ HR++KP+NLLL A +KL DFG A ++ + + + Y +P Sbjct: 123 VLHCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSP 182 Query: 226 ELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMN 285 E++ Y +D+W+ G +L LL+G P F D +L + IK Sbjct: 183 EVLR-KDPYGKPVDLWACGVILYILLVGYPPF-WDEDQHRLYQQIKA------------- 227 Query: 286 PNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRD 345 + FP + W V PEA L +++L P+ R+T EA H + Sbjct: 228 ---GAYDFPSPE---WDTV-----TPEAKDLINKMLTINPSKRITAAEALKHPWISHRST 276 Query: 346 PNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARI 384 + L F + L +L + + Sbjct: 277 VASCMHRQETVDCLKKFNARRKLKGAILTVMLATRNFSV 315 >2W96-B nrPDB Length = 306 Score = 262 bits (669), Expect = 2e-70, Method: Composition-based stats. Identities = 86/295 (29%), Positives = 142/295 (48%), Gaps = 16/295 (5%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIK--KVLQDKR----FKNRELQIMRKLD--- 105 Y IG G++G VY+A+ SG VA+K +V + RE+ ++R+L+ Sbjct: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPISTVREVALLRRLEAFE 64 Query: 106 HCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQL 165 H N+VRL +S + E+ + LV ++V + + LP +K M Q Sbjct: 65 HPNVVRLMDVCATSRTDR-EIKVTLVFEHVDQDLRTYLDKA--PPPGLPAETIKDLMRQF 121 Query: 166 FRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAP 225 R L ++H+ I HRD+KP+N+L+ +KL DFG A+ + + +YRAP Sbjct: 122 LRGLDFLHANCIVHRDLKPENILVTS-GGTVKLADFGLARIYSYQMALDPVVVTLWYRAP 180 Query: 226 ELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMN 285 E++ +T Y + +D+WS GC+ AE+ +P+F G+S DQL +I ++G P + + Sbjct: 181 EVLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR-D 238 Query: 286 PNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF 340 + FP P V P L +L + P R++ A HS+ Sbjct: 239 VSLPRGAFPPRGPRPVQSVV-PEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL 292 >5FG8-A nrPDB Length = 285 Score = 261 bits (667), Expect = 4e-70, Method: Composition-based stats. Identities = 80/300 (26%), Positives = 126/300 (42%), Gaps = 44/300 (14%) Query: 52 QEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVL------QDKRFKNRELQIMRKLD 105 +Y + +G G+F +V + +G A K + +D + RE +I RKL Sbjct: 12 FSDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLH 71 Query: 106 HCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQL 165 H NIVRL ++E Y LV D V A++ + Q+ Sbjct: 72 HPNIVRLHDSI------QEENYHYLVFDLVTGGELF---EDIVAREFYSEADASHCIQQI 122 Query: 166 FRSLAYIHSFGICHRDIKPQNLLL--DPDTAVLKLCDFGSAKQLV-RGEPNVSYICSRYY 222 S+ + H G+ HRD+KP+NLLL A +KL DFG A ++ + + + Y Sbjct: 123 LESVNHCHQNGVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGY 182 Query: 223 RAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIR 282 +PE++ Y S+D+W+ G +L LL+G P F D +L IK Sbjct: 183 LSPEVL-KKEPYGKSVDIWACGVILYILLVGYPPF-WDEDQHRLYSQIKA---------- 230 Query: 283 EMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDE 342 + +P + W V PEA L +++L P R+T EA H + + Sbjct: 231 ------GAYDYPSPE---WDTV-----TPEAKNLINQMLTVNPNKRITAAEALKHPWICQ 276 >3UC3-A nrPDB Length = 361 Score = 260 bits (665), Expect = 6e-70, Method: Composition-based stats. Identities = 92/357 (25%), Positives = 137/357 (38%), Gaps = 46/357 (12%) Query: 40 VVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRF---KNR 96 V P P Y K IG+G+FGV + + ELVA+K + + R Sbjct: 6 VTTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGAAIDENVQR 65 Query: 97 ELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVI 156 E+ R L H NIVR + +L ++++Y Sbjct: 66 EIINHRSLRHPNIVRFKEVIL------TPTHLAIIMEYASGG---ELYERICNAGRFSED 116 Query: 157 YVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLD-PDTAVLKLCDFGSAKQLVRGEPNVS 215 + + QL ++Y HS ICHRD+K +N LLD LK+CDFG +K V S Sbjct: 117 EARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKS 176 Query: 216 YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGT 275 + + Y APE++ DVWS G L +L+G F Sbjct: 177 TVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEE------------- 223 Query: 276 PTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEAC 335 P +I + ++ R PE L SR+ P R++ E Sbjct: 224 ----------PRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEIK 273 Query: 336 AHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASPPA 392 HS+F L++ L N +T + F Q + S L TI+ +I + A+ PA Sbjct: 274 THSWF--LKNLPADLMNESNTGSQFQEPEQPMQS---LDTIM-----QIISEATIPA 320 >3N9X-A nrPDB Length = 432 Score = 260 bits (664), Expect = 9e-70, Method: Composition-based stats. Identities = 109/399 (27%), Positives = 170/399 (42%), Gaps = 69/399 (17%) Query: 54 VSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ------DKRFKNRELQIMRKLDHC 107 +Y +IG GS+G VY A ++ + VAIKKV + D + RE+ I+ +L Sbjct: 26 DNYIIKHLIGRGSYGYVYLAYDKNTEKNVAIKKVNRMFEDLIDCKRILREITILNRLKSD 85 Query: 108 NIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFR 167 I+RL K + L +VL+ + ++ + L ++K +Y L Sbjct: 86 YIIRLYDLIIPDDLLKFDE-LYIVLEIADSDLKKLF----KTPIFLTEEHIKTILYNLLL 140 Query: 168 SLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPN-------------- 213 +IH GI HRD+KP N LL+ D +V K+CDFG A+ + + Sbjct: 141 GENFIHESGIIHRDLKPANCLLNQDCSV-KVCDFGLARTINSEKDTNIVNDLEENEEPGP 199 Query: 214 ---------VSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELL-----------LG 253 S++ +R+YRAPELI +YT SID+WS GC+ AELL Sbjct: 200 HNKNLKKQLTSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAELLNMLQSHINDPTNR 259 Query: 254 QPIFPGD-----------------SGVDQLVEIIKVLGTPTREQIREMN-PNYTEF--KF 293 P+FPG S DQL I ++GTPT + ++ +N P ++ F Sbjct: 260 FPLFPGSSCFPLSPDRNSKKVHEKSNRDQLNIIFNIIGTPTEDDLKNINKPEVIKYIKLF 319 Query: 294 PQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNG 353 P K + + P + I L +L++ P R+T +A H + ++R KL N Sbjct: 320 PHRKPINLKQKY-PSISDDGINLLESMLKFNPNKRITIDQALDHPYLKDVR--KKKLENF 376 Query: 354 RDTPALFNFTTQELSSNPPLATILIPPHARIQAAASPPA 392 + F + S L I + P+ Sbjct: 377 STKKIILPFDDWMVLSETQLRYIFLKEVQSFHPELVIPS 415 >5YKS-A nrPDB Length = 377 Score = 259 bits (663), Expect = 1e-69, Method: Composition-based stats. Identities = 74/317 (23%), Positives = 130/317 (41%), Gaps = 44/317 (13%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN------RELQIMRKLDHCNI 109 Y K +G G F VV A+ +GE VA+K + + K +E++ M+ + H NI Sbjct: 37 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHPNI 96 Query: 110 VRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 169 VRL + L L+L+ + + + ++ L K Y Q+ ++ Sbjct: 97 VRLYEVI------DTQTKLYLILELGDGG--DMFDYIMKHEEGLNEDLAKKYFAQIVHAI 148 Query: 170 AYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIF 229 +Y H + HRD+KP+N++ ++KL DFG + + G+ + S Y APE++ Sbjct: 149 SYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILL 208 Query: 230 GATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYT 289 G ++D+WS G +L L+ GQP F + + L I+ Sbjct: 209 GDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDC----------------- 251 Query: 290 EFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVK 349 ++ P E L +R+L+ P R + E H + + DP+ Sbjct: 252 KYTVPS------------HVSKECKDLITRMLQRDPKRRASLEEIENHPWLQGV-DPSPA 298 Query: 350 LPNGRDTPALFNFTTQE 366 + N + +E Sbjct: 299 TKYNIPLVSYKNLSEEE 315 >3KK8-A nrPDB Length = 284 Score = 259 bits (661), Expect = 2e-69, Method: Composition-based stats. Identities = 81/300 (27%), Positives = 125/300 (41%), Gaps = 43/300 (14%) Query: 49 DRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVL------QDKRFKNRELQIMR 102 +Y + +G G+F VV + +G A K + +D + RE +I R Sbjct: 1 STKFSDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICR 60 Query: 103 KLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYM 162 KL H NIVRL ++E + LV D V A++ + Sbjct: 61 KLQHPNIVRLHDSI------QEESFHYLVFDLVTGGELF---EDIVAREFYSEADASHCI 111 Query: 163 YQLFRSLAYIHSFGICHRDIKPQNLLL--DPDTAVLKLCDFGSAKQLVRGEPNVSYICSR 220 Q+ S+AY HS GI HR++KP+NLLL A +KL DFG A ++ E + + Sbjct: 112 QQILESIAYCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTP 171 Query: 221 YYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQ 280 Y +PE++ Y+ +D+W+ G +L LL+G P F D +L IK Sbjct: 172 GYLSPEVL-KKDPYSKPVDIWACGVILYILLVGYPPF-WDEDQHRLYAQIKA-------- 221 Query: 281 IREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF 340 + +P + W V PEA +L +L P R+T +A + Sbjct: 222 --------GAYDYPSPE---WDTV-----TPEAKSLIDSMLTVNPKKRITADQALKVPWI 265 >6O6Q-A nrPDB Length = 335 Score = 258 bits (660), Expect = 3e-69, Method: Composition-based stats. Identities = 94/306 (30%), Positives = 149/306 (48%), Gaps = 25/306 (8%) Query: 51 PQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFK-NRELQIMRKL-DHCN 108 PQE +Y + +G G + V+ + E V IK + KR K RE+ I++ L D N Sbjct: 39 PQE-NYEILRKLGRGKYSEVFLGIDLEKREKVVIKVLKPVKRKKIKREISILKNLVDGPN 97 Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRS 168 I+ + K L+ +++ +R T ++ YMY+L ++ Sbjct: 98 IIAMLDVVREPQSKTP----GLIFEHINNIDFRSL------YPTFTDYDIRFYMYELLKA 147 Query: 169 LAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELI 228 L Y HS GI HRD+KP N+++D D +L+L D+G A+ G + SRY++ PEL+ Sbjct: 148 LDYSHSMGIMHRDVKPHNVMIDHDKKLLRLIDWGLAEYYHPGTEYNVRVASRYFKGPELL 207 Query: 229 FGATDYTSSIDVWSAGCVLAEL-LLGQPIFPGDSGVDQLVEIIKVLGTPTREQIRE---- 283 Y S+D+WS GC+LA + + +P F G S DQLV+I++VLG+ ++ E Sbjct: 208 VDYRLYDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQLVQIVRVLGSKNFKKYLEKYNI 267 Query: 284 -MNPNYTEFKFPQIKAHPWTKVF----RPRTPPEAIALCSRLLEYTPTARLTPLEACAHS 338 + Y + + W + + E + L RLL Y RLT EA H+ Sbjct: 268 SLGEEYEDIGYYN--KRQWVRFMNENNKDLVSQEFLDLIDRLLRYDHQERLTAKEAMKHA 325 Query: 339 FFDELR 344 +FD +R Sbjct: 326 YFDPIR 331 >3NIE-A nrPDB Length = 429 Score = 258 bits (659), Expect = 4e-69, Method: Composition-based stats. Identities = 109/412 (26%), Positives = 169/412 (41%), Gaps = 74/412 (17%) Query: 54 VSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ------DKRFKNRELQIMRKLDHC 107 +Y +IG GS+G VY A ++ + VAIKKV + D + RE+ I+ +L Sbjct: 28 DNYEIKHLIGRGSYGYVYLAYDKNANKNVAIKKVNRMFEDLIDCKRILREITILNRLKSD 87 Query: 108 NIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFR 167 I+RL K + L +VL+ + ++ + L +VK +Y L Sbjct: 88 YIIRLHDLIIPEDLLKFDE-LYIVLEIADSDLKKLF----KTPIFLTEQHVKTILYNLLL 142 Query: 168 SLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRG----------------- 210 +IH GI HRD+KP N LL+ D +V K+CDFG A+ + Sbjct: 143 GEKFIHESGIIHRDLKPANCLLNQDCSV-KICDFGLARTINSDKDIHIVNDLEEKEENEE 201 Query: 211 ---------EPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELL---------- 251 + S++ +R+YRAPELI +YT+SID+WS GC+ AELL Sbjct: 202 PGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTGCIFAELLNMMKSHINNP 261 Query: 252 -LGQPIFPGD-----------------SGVDQLVEIIKVLGTPTREQIREMNP----NYT 289 P+FPG S DQL I V+GTP E ++ + Y Sbjct: 262 TNRFPLFPGSSCFPLSPDHNSKKVHEKSNRDQLNIIFNVIGTPPEEDLKCITKQEVIKYI 321 Query: 290 EFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVK 349 + FP +K + E I L +L + R+T +A +H + ++R N++ Sbjct: 322 KL-FPTRDGIDLSKKYSS-ISKEGIDLLESMLRFNAQKRITIDKALSHPYLKDVRKENLE 379 Query: 350 LPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASPPANATAASDTN 401 + + F + S L I + A PA + Sbjct: 380 NFSTEKI--ILPFDDWMVLSETQLRYIFLKEIQSFHADLIIPAKLNIHQKSF 429 >3MN3-A nrPDB Length = 271 Score = 258 bits (658), Expect = 5e-69, Method: Composition-based stats. Identities = 76/308 (24%), Positives = 121/308 (39%), Gaps = 48/308 (15%) Query: 51 PQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFK-------NRELQIMRK 103 +Y K +G GSFG V A +G+ VA+K + + K RE+ +R Sbjct: 1 AHIGNYQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRL 60 Query: 104 LDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMY 163 L H +I++L S E + +V++Y ++ Y + + + + Sbjct: 61 LRHPHIIKLYDVIKSKDE------IIMVIEYAGNELFD----YIVQRDKMSEQEARRFFQ 110 Query: 164 QLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYR 223 Q+ ++ Y H I HRD+KP+NLLLD V K+ DFG + + G + S Y Sbjct: 111 QIISAVEYCHRHKIVHRDLKPENLLLDEHLNV-KIADFGLSNIMTDGNFLKTSCGSPNYA 169 Query: 224 APELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIRE 283 APE+I G +DVWS G +L +L + F +S I + Sbjct: 170 APEVISGKLYAGPEVDVWSCGVILYVMLCRRLPFDDESIPVLFKNISNGV---------- 219 Query: 284 MNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDEL 343 + P+ P A L R+L P R++ E +F + Sbjct: 220 -------YTLPKF------------LSPGAAGLIKRMLIVNPLNRISIHEIMQDDWFK-V 259 Query: 344 RDPNVKLP 351 P LP Sbjct: 260 DLPEYLLP 267 >2J90-A nrPDB Length = 304 Score = 256 bits (655), Expect = 1e-68, Method: Composition-based stats. Identities = 74/310 (23%), Positives = 127/310 (40%), Gaps = 48/310 (15%) Query: 53 EVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ----------DKRFKNRELQIMR 102 E Y + +G+G F +V + + +G+ A K + + + RE+ I+R Sbjct: 25 EDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILR 84 Query: 103 KLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYM 162 ++ H NI+ L F E K +V L L L E +A K++L ++ Sbjct: 85 EIRHPNIITLHDIF----ENKTDVVLILELVSGGELFDFLAE-----KESLTEDEATQFL 135 Query: 163 YQLFRSLAYIHSFGICHRDIKPQNLLL---DPDTAVLKLCDFGSAKQLVRGEPNVSYICS 219 Q+ + Y+HS I H D+KP+N++L + +KL DFG A ++ G + + Sbjct: 136 KQILDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGT 195 Query: 220 RYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTRE 279 + APE++ D+WS G + LL G F G++ + L I V Sbjct: 196 PEFVAPEIV-NYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAV------- 247 Query: 280 QIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSF 339 + + + + T A RLL P R+T ++ HS+ Sbjct: 248 ------------------NYDFDEEYFSNTSELAKDFIRRLLVKDPKRRMTIAQSLEHSW 289 Query: 340 FDELRDPNVK 349 +R NV+ Sbjct: 290 IKAIRRRNVR 299 >5ZTN-A nrPDB Length = 429 Score = 256 bits (654), Expect = 1e-68, Method: Composition-based stats. Identities = 96/351 (27%), Positives = 155/351 (44%), Gaps = 54/351 (15%) Query: 46 QGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNR---ELQIMR 102 Q P Y KVIG GSFG V +A + VA+K V +KRF + E++I+ Sbjct: 89 QVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILE 148 Query: 103 KLDHC------NIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVI 156 L N++ + F ++ + + + +Y + + +LP+ Sbjct: 149 HLRKQDKDNTMNVIHMLENFTFRN------HICMTFELLSMNLYELIKKNKFQGFSLPL- 201 Query: 157 YVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAV-LKLCDFGSAKQLVRGEPNVS 215 V+ + + + + L +H I H D+KP+N+LL +K+ DFGS+ + + Sbjct: 202 -VRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSS--CYEHQRVYT 258 Query: 216 YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGT 275 YI SR+YRAPE+I GA Y ID+WS GC+LAELL G P+ PG+ DQL +I++LG Sbjct: 259 YIQSRFYRAPEVILGAR-YGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGM 317 Query: 276 PTREQIREMNPNYTEFK---FPQI---------------------------KAHPWTKVF 305 P+++ + +P+ ++ W Sbjct: 318 PSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNAL 377 Query: 306 RPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDT 356 + P + + LE+ P R+TP +A H + LR K P G T Sbjct: 378 KGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPW---LRRRLPKPPTGEKT 425 >5IG1-A nrPDB Length = 344 Score = 255 bits (652), Expect = 2e-68, Method: Composition-based stats. Identities = 90/369 (24%), Positives = 139/369 (37%), Gaps = 53/369 (14%) Query: 47 GPDRPQEVSY---------TDTKVIGNGSFGVVYQAKLCDSGELVAIKKV------LQDK 91 GP E S+ VIG G+F V++ +GE+ A+K + + Sbjct: 1 GPHMETETSFFDLYDVDLKDKRSVIGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRSSEI 60 Query: 92 RFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQ 151 RE+ I L H +IV +R F +DE + LV +YV ++ Sbjct: 61 NKIKREIGICSSLQHEHIVSMRRAF------RDESHFYLVFEYVSGGELF---DEIVTRK 111 Query: 152 TLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLL--DPDTAVLKLCDFGSAKQLVR 209 M+Q+ +L + HS I HRD+KP+NLLL A +K+ DFG A + + Sbjct: 112 FYNEKDASACMHQILSALQHCHSKNIIHRDLKPENLLLASKDPNAPVKITDFGLAVIMEQ 171 Query: 210 GEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEI 269 G + + Y +PE+I Y +++DVW+ G +L LL+G P F + +I Sbjct: 172 GPTYFGFAGTPGYLSPEVIR-RVPYDTAVDVWACGVILYILLVGYPPFWEEDHQKLYAQI 230 Query: 270 IKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARL 329 ++ FP + W V A L +LE P R Sbjct: 231 KNC-----------------QYDFPSPE---WDSV-----TTAAKELIKAMLEPNPKRRP 265 Query: 330 TPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAAS 389 T E H + RD + L F + A I + R A+ Sbjct: 266 TVQELLQHPWIAR-RDVPGSVHRQATLEELKKFNARRKLKGGVNAVIGVSKMMRTMQEAT 324 Query: 390 PPANATAAS 398 +A S Sbjct: 325 RALTLSAKS 333 >3TAC-A nrPDB Length = 361 Score = 255 bits (652), Expect = 2e-68, Method: Composition-based stats. Identities = 88/369 (23%), Positives = 133/369 (36%), Gaps = 56/369 (15%) Query: 49 DRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDK---------RFKNRELQ 99 D E Y +VIG G F VV + ++G+ A+K V K RE Sbjct: 21 DVLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREAS 80 Query: 100 IMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPE-TVYRVARHYSRAKQTLPVIYV 158 I L H +IV L + S G L +V +++ + + A Sbjct: 81 ICHMLKHPHIVELLETYSSDG------MLYMVFEFMDGADLCFEIVKRADAGFVYSEAVA 134 Query: 159 KLYMYQLFRSLAYIHSFGICHRDIKPQNLLL--DPDTAVLKLCDFGSAKQLVR-GEPNVS 215 YM Q+ +L Y H I HRD+KP +LL ++A +KL FG A QL G Sbjct: 135 SHYMRQILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGG 194 Query: 216 YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVE-IIKVLG 274 + + ++ APE++ Y +DVW G +L LL G F G ++L E IIK Sbjct: 195 RVGTPHFMAPEVV-KREPYGKPVDVWGCGVILFILLSGCLPFYG--TKERLFEGIIKGK- 250 Query: 275 TPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEA 334 ++ W+ + A L R+L P R+T EA Sbjct: 251 -------------------YKMNPRQWSHI-----SESAKDLVRRMLMLDPAERITVYEA 286 Query: 335 CAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPL--------ATILIPPHARIQA 386 H + E K+ L F + L + P + Sbjct: 287 LNHPWLKERDRYAYKIHLPETVEQLRKFNARRKLKGAVLAAVSSHKFNSFYGDPPEELPD 346 Query: 387 AASPPANAT 395 + P ++ Sbjct: 347 FSEDPTSSG 355 >5ES1-A nrPDB Length = 328 Score = 254 bits (649), Expect = 4e-68, Method: Composition-based stats. Identities = 72/318 (22%), Positives = 124/318 (38%), Gaps = 47/318 (14%) Query: 49 DRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ------DKRFKNRELQIMR 102 ++P +Y + IG G+F V A+ +G VAIK + + + RE++IM+ Sbjct: 10 EQPHVGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMK 69 Query: 103 KLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVP-ETVYRVARHYSRAKQTLPVIYVKLY 161 L+H NIV+L + E L LV++Y V+ + R K + Sbjct: 70 GLNHPNIVKLFEVI------ETEKTLYLVMEYASAGEVFDYLVSHGRMK----EKEARAK 119 Query: 162 MYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY 221 Q+ ++ Y H I HRD+K +NLLLD + +K+ DFG + + G ++ S Sbjct: 120 FRQIVSAVHYCHQKNIVHRDLKAENLLLDAEAN-IKIADFGFSNEFTLGSKLDTFCGSPP 178 Query: 222 YRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQI 281 Y APEL G +D+WS G +L L+ G F G + + +++ Sbjct: 179 YAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLR---------- 228 Query: 282 REMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFD 341 +++ P + ++ R L P R T + + + Sbjct: 229 -------GKYRVPFYMSTDCE------------SILRRFLVLNPAKRCTLEQIMKDKWIN 269 Query: 342 ELRDPNVKLPNGRDTPAL 359 + P Sbjct: 270 IGYEGEELKPYTEPEEDF 287 >5Y86-A nrPDB Length = 588 Score = 254 bits (648), Expect = 6e-68, Method: Composition-based stats. Identities = 98/388 (25%), Positives = 162/388 (41%), Gaps = 54/388 (13%) Query: 46 QGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNR---ELQIMR 102 P Y K+IG GSFG V + + VA+K V +KRF + E++I+ Sbjct: 199 HVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILE 258 Query: 103 KLDHC------NIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVI 156 L N++ + F ++ + + + +Y + + Q V Sbjct: 259 HLKKQDKTGSMNVIHMLESFTFRN------HVCMAFELLSIDLYELIKK--NKFQGFSVQ 310 Query: 157 YVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDT-AVLKLCDFGSAKQLVRGEPNVS 215 V+ + + +SL +H I H D+KP+N+LL + K+ DFGS+ + + Sbjct: 311 LVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEY--QKLYT 368 Query: 216 YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGT 275 YI SR+YRAPE+I G+ Y++ ID+WS GC+LAELL GQP+FPG+ DQL ++++LG Sbjct: 369 YIQSRFYRAPEIILGSR-YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGM 427 Query: 276 PTREQIREMN-----------PNYTEFKFP-------------------QIKAHPWTKVF 305 P + + + P Y + W Sbjct: 428 PPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTAL 487 Query: 306 RPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF-DELRDP--NVKLPNGRDTPALFNF 362 + I R L + P+ARLTP +A H + + P + +G+ + Sbjct: 488 KGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKRVVNPASA 547 Query: 363 TTQELSSNPPLATILIPPHARIQAAASP 390 S PP+ I A + + + Sbjct: 548 FQGLGSKLPPVVGIANKLKANLMSETNG 575 >2JC6-A nrPDB Length = 334 Score = 253 bits (647), Expect = 9e-68, Method: Composition-based stats. Identities = 71/346 (20%), Positives = 130/346 (37%), Gaps = 42/346 (12%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQD-----KRFKNRELQIMRKLDHCNIV 110 + + +G G+F V A+ +G+L A+K + + + E+ ++RK+ H NIV Sbjct: 24 FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIV 83 Query: 111 RLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLA 170 L + E + +YL + L E R+ K + Q+ ++ Sbjct: 84 ALEDIY----ESPNHLYLVMQLVSGGELFDRIVE-----KGFYTEKDASTLIRQVLDAVY 134 Query: 171 YIHSFGICHRDIKPQNLLL--DPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELI 228 Y+H GI HRD+KP+NLL + + + + DFG +K +G+ + + Y APE++ Sbjct: 135 YLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVL 194 Query: 229 FGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNY 288 Y+ ++D WS G + LL G P F ++ +I+K Sbjct: 195 -AQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKA---------------- 237 Query: 289 TEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNV 348 + + + A L+E P R T +A H + N Sbjct: 238 ---------EYEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALNK 288 Query: 349 KLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASPPANA 394 + NF + ++ ++ +NA Sbjct: 289 NIHESVSAQIRKNFAKSKWRQAFNATAVVRHMRKLHLGSSLDSSNA 334 >4PDS-A nrPDB Length = 347 Score = 253 bits (645), Expect = 2e-67, Method: Composition-based stats. Identities = 85/336 (25%), Positives = 143/336 (42%), Gaps = 62/336 (18%) Query: 34 GSKVTTVVATPGQGPDRPQEV---------SYTDT-KVIGNGSFGVVYQAKLCDSGELVA 83 G+ T+ +A+PG + ++ +V+G G+F V +A +G+ + Sbjct: 1 GAMATSKIASPGLTSSTASSMVANKTGIFKDFSIIDEVVGQGAFATVKKAIERTTGKTFS 60 Query: 84 IKKVLQDKRFKN-----RELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPET 138 +K + + K N REL++++KL+H IVRL+ F+ +D +V+++V Sbjct: 61 VKIISKRKVIGNMDGVTRELEVLQKLNHPRIVRLKGFY------EDTESYYMVMEFVSGG 114 Query: 139 VYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVL-K 197 + A + + Q+ ++ YIHS GI HRD+KP N+L++ D VL K Sbjct: 115 ---DLMDFVAAHGAVGEDAGREISRQILTAIKYIHSMGISHRDLKPDNILIEQDDPVLVK 171 Query: 198 LCDFGSAKQLVRGEPNVSYICSRYYRAPELIFG------------ATDYTSSIDVWSAGC 245 + FG AK G ++ + Y APE+I G +Y+S +D+WS GC Sbjct: 172 ITAFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSPDEYEERNEYSSLVDMWSMGC 231 Query: 246 VLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVF 305 ++ +L G F G S DQL + I + + + Sbjct: 232 LVYVILTGHLPFSG-STQDQLYKQI------------------GRGSYHEGPLKDF---- 268 Query: 306 RPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFD 341 R EA LL+ P R T +A H + Sbjct: 269 --RISEEARDFIDSLLQVDPNNRSTAAKALNHPWIK 302 >4FG9-A nrPDB Length = 320 Score = 252 bits (644), Expect = 2e-67, Method: Composition-based stats. Identities = 72/294 (24%), Positives = 119/294 (40%), Gaps = 44/294 (14%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRF-----KNRELQIMRKLDHCNIV 110 Y V+G G+F V A+ + +LVAIK + ++ E+ ++ K+ H NIV Sbjct: 20 YDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMENEIAVLHKIKHPNIV 79 Query: 111 RLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLA 170 L + S G +YL + L E R+ K ++Q+ ++ Sbjct: 80 ALDDIYESGG----HLYLIMQLVSGGELFDRIVE-----KGFYTERDASRLIFQVLDAVK 130 Query: 171 YIHSFGICHRDIKPQNLL---LDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPEL 227 Y+H GI HRD+KP+NLL LD D+ ++ + DFG +K G + + Y APE+ Sbjct: 131 YLHDLGIVHRDLKPENLLYYSLDEDSKIM-ISDFGLSKMEDPGSVLSTACGTPGYVAPEV 189 Query: 228 IFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPN 287 + Y+ ++D WS G + LL G P F ++ +I+K Sbjct: 190 L-AQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKA--------------- 233 Query: 288 YTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFD 341 + + + A L+E P R T +A H + Sbjct: 234 ----------EYEFDSPYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIA 277 >2QNJ-A nrPDB Length = 328 Score = 252 bits (644), Expect = 2e-67, Method: Composition-based stats. Identities = 75/310 (24%), Positives = 124/310 (40%), Gaps = 47/310 (15%) Query: 49 DRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ------DKRFKNRELQIMR 102 ++P +Y K IG G+F V A+ +G VAIK + + + RE++IM+ Sbjct: 7 EQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMK 66 Query: 103 KLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPET-VYRVARHYSRAKQTLPVIYVKLY 161 L+H NIV+L + E L L+++Y V+ + R K + Sbjct: 67 ILNHPNIVKLFEVI------ETEKTLYLIMEYASGGEVFDYLVAHGRMK----EKEARSK 116 Query: 162 MYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY 221 Q+ ++ Y H I HRD+K +NLLLD D +K+ DFG + + G ++ S Sbjct: 117 FRQIVSAVQYCHQKRIVHRDLKAENLLLDADMN-IKIADFGFSNEFTVGGKLDTFCGSPP 175 Query: 222 YRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQI 281 Y APEL G +DVWS G +L L+ G F G + + +++ Sbjct: 176 YAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLR---------- 225 Query: 282 REMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFD 341 +++ P + L R L P R T + + + Sbjct: 226 -------GKYRIPFYMSTDCEN------------LLKRFLVLNPIKRGTLEQIMKDRWIN 266 Query: 342 ELRDPNVKLP 351 + + P Sbjct: 267 AGHEEDELKP 276 >5WAX-A nrPDB Length = 310 Score = 251 bits (642), Expect = 3e-67, Method: Composition-based stats. Identities = 83/340 (24%), Positives = 129/340 (37%), Gaps = 40/340 (11%) Query: 46 QGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRF---KNRELQIMR 102 P Y + IG+G+FGV + G+LVA+K + + ++ RE+ R Sbjct: 3 DMPIMHDGDRYELVRDIGSGNFGVARLMRNRADGQLVAVKYIERGEKIDENVQREIINHR 62 Query: 103 KLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYM 162 L H NI+R + +L +V++Y + + Sbjct: 63 SLRHPNIIRFKEVIL------TPTHLAIVMEYASGGELF---ERICNAGRFSEDEARFFF 113 Query: 163 YQLFRSLAYIHSFGICHRDIKPQNLLLDPDTA-VLKLCDFGSAKQLVRGEPNVSYICSRY 221 QL ++Y HS +CHRD+K +N LLD TA LK+CDFG +K V S + + Sbjct: 114 QQLISGVSYCHSMQVCHRDLKLENTLLDGSTAPRLKICDFGYSKSSVLHSQPKSTVGTPA 173 Query: 222 YRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVE-IIKVLGTPTREQ 280 Y APE++ DVWS G L +L+G F + I ++LG Sbjct: 174 YIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILG------ 227 Query: 281 IREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF 340 ++ P PE L SR+ P R+T E H +F Sbjct: 228 --------VQYSIPDY----------VHISPECQDLISRIFVANPATRITIPEIRNHPWF 269 Query: 341 DELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPP 380 L++ L + + Q + S + IL Sbjct: 270 --LKNLPADLMDDSTMSKQYEEPEQPMQSMDEIMQILAEA 307 >2JAM-A nrPDB Length = 304 Score = 251 bits (641), Expect = 4e-67, Method: Composition-based stats. Identities = 73/293 (24%), Positives = 123/293 (41%), Gaps = 42/293 (14%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFK----NRELQIMRKLDHCNIV 110 ++ +V+G+G+F V+ K +G+L A+K + + F+ E+ +++K+ H NIV Sbjct: 10 TFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSSLENEIAVLKKIKHENIV 69 Query: 111 RLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLA 170 L + E YL + L E R+ L + Q+ ++ Sbjct: 70 TLEDIY----ESTTHYYLVMQLVSGGELFDRILER-----GVYTEKDASLVIQQVLSAVK 120 Query: 171 YIHSFGICHRDIKPQNLLL--DPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELI 228 Y+H GI HRD+KP+NLL + + + + DFG +K G + + + Y APE++ Sbjct: 121 YLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIMSTA-CGTPGYVAPEVL 179 Query: 229 FGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNY 288 Y+ ++D WS G + LL G P F ++ +I + Y Sbjct: 180 -AQKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKE---------------GY 223 Query: 289 TEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFD 341 EF+ P F A LLE P R T +A +H + D Sbjct: 224 YEFESP----------FWDDISESAKDFICHLLEKDPNERYTCEKALSHPWID 266 >5KZ7-A nrPDB Length = 346 Score = 251 bits (640), Expect = 6e-67, Method: Composition-based stats. Identities = 75/320 (23%), Positives = 128/320 (40%), Gaps = 47/320 (14%) Query: 49 DRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ------DKRFKNRELQIMR 102 ++P +Y K IG G+F V A+ +G+ VA+K + + + RE++IM+ Sbjct: 28 EQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMK 87 Query: 103 KLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPET-VYRVARHYSRAKQTLPVIYVKLY 161 L+H NIV+L + E L LV++Y V+ + R K + Sbjct: 88 VLNHPNIVKLFEVI------ETEKTLYLVMEYASGGEVFDYLVAHGRMK----EKEARAK 137 Query: 162 MYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY 221 Q+ ++ Y H I HRD+K +NLLLD D +K+ DFG + + G ++ S Sbjct: 138 FRQIVSAVQYCHQKFIVHRDLKAENLLLDADMN-IKIADFGFSNEFTFGNKLDTFCGSPP 196 Query: 222 YRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQI 281 Y APEL G +DVWS G +L L+ G F G + + +++ Sbjct: 197 YAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLR---------- 246 Query: 282 REMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFD 341 +++ P + L + L P+ R T + + + Sbjct: 247 -------GKYRIPFYMSTDCEN------------LLKKFLILNPSKRGTLEQIMKDRWMN 287 Query: 342 ELRDPNVKLPNGRDTPALFN 361 + + P P + Sbjct: 288 VGHEDDELKPYVEPLPDYKD 307 >3F3Z-A nrPDB Length = 277 Score = 250 bits (639), Expect = 7e-67, Method: Composition-based stats. Identities = 86/293 (29%), Positives = 131/293 (44%), Gaps = 42/293 (14%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ----DKRFKNRELQIMRKLDHCNIVR 111 YT IG GS+G V A + A KK+ + D +E++IM+ LDH NI+R Sbjct: 11 YTLENTIGRGSWGEVKIAVQKGTRIRRAAKKIPKYFVEDVDRFKQEIEIMKSLDHPNIIR 70 Query: 112 LRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAY 171 L F E ++YL + L E RV K+ M + ++AY Sbjct: 71 LYETF----EDNTDIYLVMELCTGGELFERVVH-----KRVFRESDAARIMKDVLSAVAY 121 Query: 172 IHSFGICHRDIKPQNLLL--DPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIF 229 H + HRD+KP+N L D + LKL DFG A + G+ + + + YY +P+++ Sbjct: 122 CHKLNVAHRDLKPENFLFLTDSPDSPLKLIDFGLAARFKPGKMMRTKVGTPYYVSPQVLE 181 Query: 230 GATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYT 289 G Y D WSAG ++ LL G P F + + +++I Sbjct: 182 G--LYGPECDEWSAGVMMYVLLCGYPPFSAPTDSEVMLKI-----------------REG 222 Query: 290 EFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDE 342 F FP+ W V P+A +L RLL +P R+T L+A H +F++ Sbjct: 223 TFTFPE---KDWLNV-----SPQAESLIRRLLTKSPKQRITSLQALEHEWFEK 267 >5D9K-A nrPDB Length = 330 Score = 250 bits (638), Expect = 8e-67, Method: Composition-based stats. Identities = 94/366 (25%), Positives = 153/366 (41%), Gaps = 65/366 (17%) Query: 30 RDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLC---DSGELVAIKK 86 ++ K + +G ++ + KV+G GSFG V+ K D+ +L A+K Sbjct: 6 TEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKV 65 Query: 87 VLQ------DKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVY 140 + + D+ E I+ +++H IV+L Y F + G+ L L+LD++ Sbjct: 66 LKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGK------LYLILDFLRGG-- 117 Query: 141 RVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCD 200 + S+ + VK Y+ +L +L ++HS GI +RD+KP+N+LLD + +KL D Sbjct: 118 DLFTRLSK-EVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGH-IKLTD 175 Query: 201 FGSAKQLVRGEPN-VSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPG 259 FG +K+ + E S+ + Y APE++ +T S D WS G ++ E+L G F G Sbjct: 176 FGLSKESIDHEKKAYSFCGTVEYMAPEVV-NRRGHTQSADWWSFGVLMFEMLTGTLPFQG 234 Query: 260 DSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSR 319 + + I+K + PQ PEA +L Sbjct: 235 KDRKETMTMILKA-----------------KLGMPQF------------LSPEAQSLLRM 265 Query: 320 LLEYTPTARLTP-----LEACAHSFFDELR---------DPNVKLPNGRDTPALFNFTTQ 365 L + P RL E HSFF + P K GR F F + Sbjct: 266 LFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGR-PEDTFYFDPE 324 Query: 366 ELSSNP 371 + P Sbjct: 325 FTAKTP 330 >3IS5-A nrPDB Length = 285 Score = 249 bits (637), Expect = 1e-66, Method: Composition-based stats. Identities = 76/297 (25%), Positives = 132/297 (44%), Gaps = 40/297 (13%) Query: 53 EVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDK-----RFKNRELQIMRKLDHC 107 + + + +G+G+FG V+ + SG IK + +D+ E+++++ LDH Sbjct: 21 DDLFIFKRKLGSGAFGDVHLVEERSSGLERVIKTINKDRSQVPMEQIEAEIEVLKSLDHP 80 Query: 108 NIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFR 167 NI+++ F E +Y+ + E + R+ +R K L YV M Q+ Sbjct: 81 NIIKIFEVF----EDYHNMYIVMETCEGGELLERIVSAQARGK-ALSEGYVAELMKQMMN 135 Query: 168 SLAYIHSFGICHRDIKPQNLLL--DPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAP 225 +LAY HS + H+D+KP+N+L + +K+ DFG A+ E + + + Y AP Sbjct: 136 ALAYFHSQHVVHKDLKPENILFQDTSPHSPIKIIDFGLAELFKSDEHSTNAAGTALYMAP 195 Query: 226 ELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMN 285 E+ D T D+WSAG V+ LL G F G S + +++ Sbjct: 196 EVF--KRDVTFKCDIWSAGVVMYFLLTGCLPFTGTSLEE------------VQQKATYKE 241 Query: 286 PNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDE 342 PNY ++ P T P+A+ L ++L P R + + H +F + Sbjct: 242 PNYA------VECRPLT--------PQAVDLLKQMLTKDPERRPSAAQVLHHEWFKQ 284 >2YAB-A nrPDB Length = 361 Score = 249 bits (637), Expect = 1e-66, Method: Composition-based stats. Identities = 71/334 (21%), Positives = 129/334 (38%), Gaps = 49/334 (14%) Query: 47 GPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQD----------KRFKNR 96 + E Y + +G+G F +V + + +G A K + + + R Sbjct: 5 FKQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIER 64 Query: 97 ELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVI 156 E+ I+R++ H NI+ L + + + + L+L+ V + K++L Sbjct: 65 EVSILRQVLHPNIITLHDVYENRTD------VVLILELVSGGELF---DFLAQKESLSEE 115 Query: 157 YVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLL---DPDTAVLKLCDFGSAKQLVRGEPN 213 ++ Q+ + Y+H+ I H D+KP+N++L + +KL DFG A ++ G Sbjct: 116 EATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEF 175 Query: 214 VSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVL 273 + + + APE++ D+WS G + LL G F GD+ + L I V Sbjct: 176 KNIFGTPEFVAPEIV-NYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAV- 233 Query: 274 GTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLE 333 ++ + + F +T A +LL RLT E Sbjct: 234 ------------------------SYDFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQE 269 Query: 334 ACAHSFFDELRDPNVKLPNGRDTPALFNFTTQEL 367 A H + + D + L NF Q + Sbjct: 270 ALRHPWITPV-DTQQAMVRRESVVNLENFKKQYV 302 >4MD7-E nrPDB Length = 391 Score = 249 bits (637), Expect = 1e-66, Method: Composition-based stats. Identities = 109/397 (27%), Positives = 178/397 (44%), Gaps = 44/397 (11%) Query: 27 KVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKK 86 +V D + + + + Y + +G G + V++A + E V +K Sbjct: 10 RVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKI 69 Query: 87 VLQDKRFKNRE----LQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRV 142 + K+ K + L+ +R NI+ L + LV ++V T ++ Sbjct: 70 LKPVKKKKIKREIKILENLRG--GPNIITLADIVKDPVSRTPA----LVFEHVNNTDFKQ 123 Query: 143 ARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFG 202 QTL ++ YMY++ ++L Y HS GI HRD+KP N+++D + L+L D+G Sbjct: 124 L------YQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWG 177 Query: 203 SAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQ-PIFPGDS 261 A+ G+ + SRY++ PEL+ Y S+D+WS GC+LA ++ + P F G Sbjct: 178 LAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHD 237 Query: 262 GVDQLVEIIKVLGTPT-----REQIREMNPNYTEFKFPQIKAHPWTKVFRPRT----PPE 312 DQLV I KVLGT + E++P + + + W + PE Sbjct: 238 NYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDI-LGRHSRKRWERFVHSENQHLVSPE 296 Query: 313 AIALCSRLLEYTPTARLTPLEACAHSFF-----DELRDPNVKLPNGRDTPALFNFTTQEL 367 A+ +LL Y +RLT EA H +F D+ R + +P G + + N + + Sbjct: 297 ALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSEPVSSANMMSG-I 355 Query: 368 SSNP---PLATILIPPHARIQAAASP-----PANATA 396 SS P PL + P + AAA+P PA A A Sbjct: 356 SSVPEPEPLGPLAGEP---VIAAANPLGMPVPAAAGA 389 >1PHK-A nrPDB Length = 298 Score = 249 bits (635), Expect = 2e-66, Method: Composition-based stats. Identities = 81/325 (24%), Positives = 122/325 (37%), Gaps = 54/325 (16%) Query: 38 TTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKV---------- 87 T A PG +Y +++G G VV + + + A+K + Sbjct: 1 TRDAALPGSHSTHGFYENYEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSA 60 Query: 88 ---LQDKRFKNRELQIMRKLD-HCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVA 143 + + +E+ I+RK+ H NI++L+ + + + LV D + + Sbjct: 61 EEVQELREATLKEVDILRKVSGHPNIIQLKDTY------ETNTFFFLVFDLMKKGELF-- 112 Query: 144 RHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGS 203 Y K TL + M L + +H I HRD+KP+N+LLD D +KL DFG Sbjct: 113 -DYLTEKVTLSEKETRKIMRALLEVICALHKLNIVHRDLKPENILLDDDMN-IKLTDFGF 170 Query: 204 AKQLVRGEPNVSYICSRYYRAPELIF-----GATDYTSSIDVWSAGCVLAELLLGQPIFP 258 + QL GE + Y APE+I Y +D+WS G ++ LL G P F Sbjct: 171 SCQLDPGEKLREVCGTPSYLAPEIIECSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPFW 230 Query: 259 GDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCS 318 + L I+ Q + W L S Sbjct: 231 HRKQMLMLRMIMSGN--------------------YQFGSPEW-----DDYSDTVKDLVS 265 Query: 319 RLLEYTPTARLTPLEACAHSFFDEL 343 R L P R T EA AH FF + Sbjct: 266 RFLVVQPQKRYTAEEALAHPFFQQY 290 >2A27-A nrPDB Length = 321 Score = 249 bits (635), Expect = 2e-66, Method: Composition-based stats. Identities = 75/345 (21%), Positives = 135/345 (39%), Gaps = 51/345 (14%) Query: 45 GQGPDRPQEVS--YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ----------DKR 92 G P + Q+V Y + +G+G F +V + + +G A K + + + Sbjct: 1 GMEPFKQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSRE 60 Query: 93 FKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQT 152 RE+ I+R++ H N++ L + + + + L+L+ V + K++ Sbjct: 61 EIEREVSILRQVLHHNVITLHDVYENRTD------VVLILELVSGGELF---DFLAQKES 111 Query: 153 LPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLL---DPDTAVLKLCDFGSAKQLVR 209 L ++ Q+ + Y+H+ I H D+KP+N++L + +KL DFG A ++ Sbjct: 112 LSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIED 171 Query: 210 GEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEI 269 G + + + APE++ D+WS G + LL G F GD+ + L I Sbjct: 172 GVEFKNIFGTPEFVAPEIV-NYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANI 230 Query: 270 IKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARL 329 V ++ + + F +T A +LL RL Sbjct: 231 TAV-------------------------SYDFDEEFFSQTSELAKDFIRKLLVKETRKRL 265 Query: 330 TPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLA 374 T EA H + + D + L NF Q + LA Sbjct: 266 TIQEALRHPWITPV-DNQQAMVRRESVVNLENFRKQYVRRRSKLA 309 >3ZUT-A nrPDB Length = 362 Score = 248 bits (634), Expect = 3e-66, Method: Composition-based stats. Identities = 87/359 (24%), Positives = 130/359 (36%), Gaps = 46/359 (12%) Query: 41 VATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRF---KNRE 97 V+ P P Y K IG+G+FGV + S ELVA+K + + ++ RE Sbjct: 6 VSGPMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKRE 65 Query: 98 LQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIY 157 + R L H NIVR + +L +V++Y Sbjct: 66 IINHRSLRHPNIVRFKEVIL------TPTHLAIVMEYASGGELF---ERICNAGRFSEDE 116 Query: 158 VKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLD-PDTAVLKLCDFGSAKQLVRGEPNVSY 216 + + QL ++Y H+ +CHRD+K +N LLD LK+C FG +K V S Sbjct: 117 ARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICAFGYSKSSVLHSQPKST 176 Query: 217 ICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTP 276 + + Y APE++ DVWS G L +L+G F Sbjct: 177 VGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEE-------------- 222 Query: 277 TREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACA 336 P +I + PE L SR+ P R++ E Sbjct: 223 ---------PKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEIRN 273 Query: 337 HSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASPPANAT 395 H +F L++ L N F+ + Q S I +I A A+ P T Sbjct: 274 HEWF--LKNLPADLMNDNTMTTQFDESDQPGQS--------IEEIMQIIAEATVPPAGT 322 >4L42-A nrPDB Length = 346 Score = 248 bits (633), Expect = 4e-66, Method: Composition-based stats. Identities = 77/367 (20%), Positives = 147/367 (40%), Gaps = 68/367 (18%) Query: 46 QGPDRPQEVSYTDTKVIGNGSFGVVYQAKLC---DSGELVAIKKVLQ--------DKRFK 94 +GP++ + + +V+G G +G V+Q + ++G++ A+K + + D Sbjct: 10 RGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHT 69 Query: 95 NRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLP 154 E I+ ++ H IV L Y F + G+ L L+L+Y+ + + Sbjct: 70 KAERNILEEVKHPFIVDLIYAFQTGGK------LYLILEYLSGGELFMQL---EREGIFM 120 Query: 155 VIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ-LVRGEPN 213 Y+ ++ +L ++H GI +RD+KP+N++L+ V KL DFG K+ + G Sbjct: 121 EDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHV-KLTDFGLCKESIHDGTVT 179 Query: 214 VSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVL 273 ++ + Y APE++ + + ++D WS G ++ ++L G P F G++ + +I+K Sbjct: 180 HTFCGTIEYMAPEILM-RSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKC- 237 Query: 274 GTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARL---- 329 P EA L +LL+ +RL Sbjct: 238 ----------------------------KLNLPPYLTQEARDLLKKLLKRNAASRLGAGP 269 Query: 330 -TPLEACAHSFFDELRDPN-----------VKLPNGRDTPALFNFTTQELSSNPPLATIL 377 E AH FF + L + D + T++ + P + L Sbjct: 270 GDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTL 329 Query: 378 IPPHARI 384 + Sbjct: 330 SEEEQEM 336 >2OU7-A nrPDB Length = 335 Score = 248 bits (632), Expect = 5e-66, Method: Composition-based stats. Identities = 80/340 (23%), Positives = 135/340 (39%), Gaps = 70/340 (20%) Query: 62 IGNGSFGVVYQAKLCDSGELVAIKKVLQD-------KRFKNRELQIMRKLDHCNIVRLRY 114 +G G F ++ D+ E+ A K V + + + E+ I R L H ++V Sbjct: 49 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 108 Query: 115 FFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHS 174 FF +D ++ +VL+ R + ++ L + Y+ Q+ Y+H Sbjct: 109 FF------EDNDFVFVVLELCRR---RSLLELHKRRKALTEPEARYYLRQIVLGCQYLHR 159 Query: 175 FGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQL-VRGEPNVSYICSRYYRAPELIFGATD 233 + HRD+K NL L+ D V K+ DFG A ++ GE + Y APE++ Sbjct: 160 NRVIHRDLKLGNLFLNEDLEV-KIGDFGLATKVEYDGERKKVLCGTPNYIAPEVL-SKKG 217 Query: 234 YTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKF 293 ++ +DVWS GC++ LL+G+P F + + I K E+ Sbjct: 218 HSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKK-----------------NEYSI 260 Query: 294 PQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNG 353 P+ P A +L ++L+ PTAR T E FF Sbjct: 261 PK------------HINPVAASLIQKMLQTDPTARPTINELLNDEFF------------- 295 Query: 354 RDTPALFNFTTQELSSNPPLATILIPPHARIQAAASPPAN 393 T+ + + P+ + IPP I ++ P+N Sbjct: 296 ---------TSGYIPARLPITCLTIPPRFSIAPSSLDPSN 326 >2YCR-A nrPDB Length = 323 Score = 248 bits (632), Expect = 5e-66, Method: Composition-based stats. Identities = 82/305 (26%), Positives = 134/305 (43%), Gaps = 50/305 (16%) Query: 54 VSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDK------------RFKNRELQIM 101 Y +K +G+G+ G V A + + VAIK + + K E++I+ Sbjct: 10 DEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEIL 69 Query: 102 RKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLY 161 +KL+H I++++ FF ++ Y+ L L E +V + L KLY Sbjct: 70 KKLNHPCIIKIKNFF-----DAEDYYIVLELMEGGELFDKVV-----GNKRLKEATCKLY 119 Query: 162 MYQLFRSLAYIHSFGICHRDIKPQNLLL--DPDTAVLKLCDFGSAKQLVRGEPNVSYICS 219 YQ+ ++ Y+H GI HRD+KP+N+LL + ++K+ DFG +K L + + Sbjct: 120 FYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGT 179 Query: 220 RYYRAPELI--FGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPT 277 Y APE++ G Y ++D WS G +L L G P F L Sbjct: 180 PTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSL----------- 228 Query: 278 REQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAH 337 ++QI N+ P++ W +V +A+ L +LL P AR T EA H Sbjct: 229 KDQITSGKYNF----IPEV----WAEV-----SEKALDLVKKLLVVDPKARFTTEEALRH 275 Query: 338 SFFDE 342 + + Sbjct: 276 PWLQD 280 >3COM-A nrPDB Length = 314 Score = 247 bits (631), Expect = 5e-66, Method: Composition-based stats. Identities = 70/323 (21%), Positives = 130/323 (40%), Gaps = 40/323 (12%) Query: 25 SMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAI 84 S++ + ++ + +P+EV + + +G GS+G VY+A ++G++VAI Sbjct: 1 SLETVQLRNPPRRQLKKLDEDSLTKQPEEV-FDVLEKLGEGSYGSVYKAIHKETGQIVAI 59 Query: 85 KKVLQDKRFKN--RELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRV 142 K+V + + +E+ IM++ D ++V+ ++ + + L +V++Y Sbjct: 60 KQVPVESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTD------LWIVMEYCGAGSVSD 113 Query: 143 ARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFG 202 +TL + + + L Y+H HRDIK N+LL+ + KL DFG Sbjct: 114 IIRLR--NKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHA-KLADFG 170 Query: 203 SAKQLVRGEPNV-SYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDS 261 A QL + I + ++ APE+I Y D+WS G E+ G+P + Sbjct: 171 VAGQLTDTMAKRNTVIGTPFWMAPEVI-QEIGYNCVADIWSLGITAIEMAEGKPPYADIH 229 Query: 262 GVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLL 321 + + I P F + + W+ F + L Sbjct: 230 PMRAIFMI----------------PTNPPPTFRKPEL--WSDNFT--------DFVKQCL 263 Query: 322 EYTPTARLTPLEACAHSFFDELR 344 +P R T + H F + Sbjct: 264 VKSPEQRATATQLLQHPFVRSAK 286 >3H4J-B nrPDB Length = 336 Score = 247 bits (631), Expect = 6e-66, Method: Composition-based stats. Identities = 72/313 (23%), Positives = 126/313 (40%), Gaps = 48/313 (15%) Query: 49 DRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFK-------NRELQIM 101 + Y + +G GSFG V A + + VA+K + + K RE+ + Sbjct: 4 SKRHIGPYIIRETLGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREISYL 63 Query: 102 RKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLY 161 + L H +I++L + + + +V++Y ++ Y K+ + + + Sbjct: 64 KLLRHPHIIKLYDVITTPTD------IVMVIEYAGGELFD----YIVEKKRMTEDEGRRF 113 Query: 162 MYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY 221 Q+ ++ Y H I HRD+KP+NLLLD + V K+ DFG + + G + S Sbjct: 114 FQQIICAIEYCHRHKIVHRDLKPENLLLDDNLNV-KIADFGLSNIMTDGNFLKTSCGSPN 172 Query: 222 YRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQI 281 Y APE+I G +DVWS G VL +L+G+ F D + L + + + + Sbjct: 173 YAAPEVINGKLYAGPEVDVWSCGIVLYVMLVGRLPFD-DEFIPNLFKKVNSCVYVMPDFL 231 Query: 282 REMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFD 341 P A +L R++ P R+T E +F+ Sbjct: 232 ----------------------------SPGAQSLIRRMIVADPMQRITIQEIRRDPWFN 263 Query: 342 ELRDPNVKLPNGR 354 + P+ P Sbjct: 264 -VNLPDYLRPMEE 275 >4CZT-A nrPDB Length = 464 Score = 246 bits (628), Expect = 1e-65, Method: Composition-based stats. Identities = 79/320 (24%), Positives = 132/320 (41%), Gaps = 50/320 (15%) Query: 44 PGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN-------R 96 PG R + Y + +G G+F V A+ ++G+ VAIK + ++K KN R Sbjct: 1 PGIHSGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKR 60 Query: 97 ELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVI 156 E+ M+ + H N++R+ K ++Y L E +++ + L Sbjct: 61 EISTMKLIKHPNVIRMFEVM----ASKTKIYFVLEFVTGGELFDKIS-----SNGRLKED 111 Query: 157 YVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSA---KQLVRGEPN 213 + Y QL ++ Y HS G+ HRD+KP+NLLLD + A LK+ DFG + +Q+ Sbjct: 112 EARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGA-LKVSDFGLSALPQQVREDGLL 170 Query: 214 VSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVL 273 + + Y APE+I + D+WS G +L L+ G F + +I K Sbjct: 171 HTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKA- 229 Query: 274 GTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLE 333 + PW A L R+L+ P R+T E Sbjct: 230 ---------------------EFTCPPW-------FSASAKKLIKRILDPNPATRITFAE 261 Query: 334 ACAHSFFDE-LRDPNVKLPN 352 + +F + + P + + Sbjct: 262 VIENEWFKKGYKAPKFENAD 281 >4NIF-A nrPDB Length = 333 Score = 246 bits (628), Expect = 2e-65, Method: Composition-based stats. Identities = 72/330 (21%), Positives = 134/330 (40%), Gaps = 45/330 (13%) Query: 47 GPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQI-MRKLD 105 G + Y + IG GS+ + + A+K + + KR + E++I +R Sbjct: 1 GSNLVFSDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIEILLRYGQ 60 Query: 106 HCNIVRLRYFFYSSGEKKDEVYLNLVLDYV--PETVYRVARHYSRAKQTLPVIYVKLYMY 163 H NI+ L+ + D ++ LV + + E + ++ R ++ ++ Sbjct: 61 HPNIITLKDVY------DDGKHVYLVTELMRGGELLDKILR-----QKFFSEREASFVLH 109 Query: 164 QLFRSLAYIHSFGICHRDIKPQNLLLDPDTA---VLKLCDFGSAKQL-VRGEPNVSYICS 219 + +++ Y+HS G+ HRD+KP N+L ++ L++CDFG AKQL ++ + Sbjct: 110 TIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYT 169 Query: 220 RYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTRE 279 + APE++ Y D+WS G +L +L G F + D EI+ +G+ Sbjct: 170 ANFVAPEVL-KRQGYDEGCDIWSLGILLYTMLAGYTPF-ANGPSDTPEEILTRIGSGKFT 227 Query: 280 QIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSF 339 + W V A L S++L P RLT + H + Sbjct: 228 ----------------LSGGNWNTV-----SETAKDLVSKMLHVDPHQRLTAKQVLQHPW 266 Query: 340 FDELRDPNVKLPNGRDTPALFNFTTQELSS 369 + KLP + + +++ Sbjct: 267 VTQ----KDKLPQSQLSHQDLQLVKGAMAA 292 >3I6U-A nrPDB Length = 419 Score = 246 bits (627), Expect = 2e-65, Method: Composition-based stats. Identities = 81/305 (26%), Positives = 134/305 (43%), Gaps = 50/305 (16%) Query: 54 VSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDK------------RFKNRELQIM 101 Y +K +G+G+ G V A + + VAI+ + + K E++I+ Sbjct: 135 DEYIMSKTLGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADPALNVETEIEIL 194 Query: 102 RKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLY 161 +KL+H I++++ FF ++ Y+ L L E +V + L KLY Sbjct: 195 KKLNHPCIIKIKNFF-----DAEDYYIVLELMEGGELFDKVV-----GNKRLKEATCKLY 244 Query: 162 MYQLFRSLAYIHSFGICHRDIKPQNLLLD--PDTAVLKLCDFGSAKQLVRGEPNVSYICS 219 YQ+ ++ Y+H GI HRD+KP+N+LL + ++K+ DFG +K L + + Sbjct: 245 FYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGT 304 Query: 220 RYYRAPELI--FGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPT 277 Y APE++ G Y ++D WS G +L L G P F L Sbjct: 305 PTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSL----------- 353 Query: 278 REQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAH 337 ++QI N+ P++ W +V +A+ L +LL P AR T EA H Sbjct: 354 KDQITSGKYNF----IPEV----WAEV-----SEKALDLVKKLLVVDPKARFTTEEALRH 400 Query: 338 SFFDE 342 + + Sbjct: 401 PWLQD 405 >6FDY-U nrPDB Length = 276 Score = 244 bits (623), Expect = 5e-65, Method: Composition-based stats. Identities = 84/314 (26%), Positives = 141/314 (44%), Gaps = 46/314 (14%) Query: 42 ATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAK-LCDSGELVAIKKVLQDK------RFK 94 A PG GP P+ + T+ +G+G++ VY+A D+ E+VAIK V + Sbjct: 1 AGPGWGP--PRLDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENL 58 Query: 95 NRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLP 154 E++I++ + H +IV+L+ F + D + L++++ + ++ LP Sbjct: 59 LTEIEILKGIRHPHIVQLKDF------QWDSDNIYLIMEFCAGG---DLSRFIHTRRILP 109 Query: 155 VIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDP-DTAVLKLCDFGSAKQLVRGEPN 213 +++M QL +L ++H I H D+KPQN+LL + LKL DFG A+ + + Sbjct: 110 EKVARVFMQQLASALQFLHERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEK 169 Query: 214 VSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVL 273 S Y APE++ Y + +D+WS G +L E L GQP F S + +I Sbjct: 170 HVLRGSPLYMAPEMVCQRQ-YDARVDLWSMGVILYEALFGQPPFASRSFSELEEKI---- 224 Query: 274 GTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLE 333 + + P RP + L RLLE P+ R++ + Sbjct: 225 ------------RSNRVIELP----------LRPLLSRDCRDLLQRLLERDPSRRISFQD 262 Query: 334 ACAHSFFDELRDPN 347 AH + D P+ Sbjct: 263 FFAHPWVDLEHMPS 276 >3UDB-A nrPDB Length = 317 Score = 244 bits (622), Expect = 6e-65, Method: Composition-based stats. Identities = 81/344 (23%), Positives = 123/344 (35%), Gaps = 38/344 (11%) Query: 41 VATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRF---KNRE 97 VA P P Y K IG G+FGV + + ELVA+K + + ++ RE Sbjct: 6 VAGPMDLPIMHDSDRYELVKDIGAGNFGVARLMRDKQANELVAVKYIERGEKIDENVKRE 65 Query: 98 LQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIY 157 + R L H NIVR + +L +V++Y Sbjct: 66 IINHRSLRHPNIVRFKEVIL------TPTHLAIVMEYASGGELF---ERICNAGRFSEDE 116 Query: 158 VKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLD-PDTAVLKLCDFGSAKQLVRGEPNVSY 216 + + QL ++Y H+ + HRD+K +N LLD LK+ DFG +K V S Sbjct: 117 ARFFFQQLISGVSYAHAMQVAHRDLKLENTLLDGSPAPRLKIADFGYSKASVLHSQPKSA 176 Query: 217 ICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTP 276 + + Y APE++ DVWS G L +L+G F Sbjct: 177 VGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEE-------------- 222 Query: 277 TREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACA 336 P +I + PE L SR+ P R++ E Sbjct: 223 ---------PKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEIRN 273 Query: 337 HSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPP 380 H +F L++ L N F+ + Q S + I+ Sbjct: 274 HEWF--LKNLPADLMNDNTMTTQFDESDQPGQSIEEIMQIIAEA 315 >2Z7Q-A nrPDB Length = 321 Score = 243 bits (620), Expect = 1e-64, Method: Composition-based stats. Identities = 85/330 (25%), Positives = 142/330 (43%), Gaps = 55/330 (16%) Query: 29 SRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLC---DSGELVAIK 85 S+D+ K ++ G ++ + KV+G GSFG V+ + DSG L A+K Sbjct: 3 SKDEGVLKEISITHHVKAGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMK 62 Query: 86 KVLQ------DKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETV 139 + + D+ E I+ ++H +V+L Y F + G+ L L+LD++ Sbjct: 63 VLKKATLKVRDRVRTKMERDILADVNHPFVVKLHYAFQTEGK------LYLILDFLRGG- 115 Query: 140 YRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLC 199 + S+ + VK Y+ +L L ++HS GI +RD+KP+N+LLD + +KL Sbjct: 116 -DLFTRLSK-EVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGH-IKLT 172 Query: 200 DFGSAKQLVRGEPN-VSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFP 258 DFG +K+ + E S+ + Y APE++ ++ S D WS G ++ E+L G F Sbjct: 173 DFGLSKEAIDHEKKAYSFCGTVEYMAPEVV-NRQGHSHSADWWSYGVLMFEMLTGSLPFQ 231 Query: 259 GDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCS 318 G + + I+K + PQ EA +L Sbjct: 232 GKDRKETMTLILKA-----------------KLGMPQF------------LSTEAQSLLR 262 Query: 319 RLLEYTPTARL-----TPLEACAHSFFDEL 343 L + P RL E H F+ + Sbjct: 263 ALFKRNPANRLGSGPDGAEEIKRHVFYSTI 292 >2X4F-A nrPDB Length = 373 Score = 243 bits (620), Expect = 1e-64, Method: Composition-based stats. Identities = 68/291 (23%), Positives = 125/291 (42%), Gaps = 39/291 (13%) Query: 57 TDTKVIGNGSFGVVYQAKLCDSGELVAIKKVL----QDKRFKNRELQIMRKLDHCNIVRL 112 + T+++G G FG V++ + +G +A K + +DK E+ +M +LDH N+++L Sbjct: 92 SKTEILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKEEVKNEISVMNQLDHANLIQL 151 Query: 113 RYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYI 172 F S + + LV++YV + L + L+M Q+ + ++ Sbjct: 152 YDAFESKND------IVLVMEYVDGG--ELFDRIIDESYNLTELDTILFMKQICEGIRHM 203 Query: 173 HSFGICHRDIKPQNLL-LDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGA 231 H I H D+KP+N+L ++ D +K+ DFG A++ E + + APE++ Sbjct: 204 HQMYILHLDLKPENILCVNRDAKQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVV-NY 262 Query: 232 TDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEF 291 + D+WS G + LL G F GD+ + L I+ E+ +++ Sbjct: 263 DFVSFPTDMWSVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEFQDI------- 315 Query: 292 KFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDE 342 EA S+LL + R++ EA H + + Sbjct: 316 ------------------SEEAKEFISKLLIKEKSWRISASEALKHPWLSD 348 >4JG6-A nrPDB Length = 355 Score = 243 bits (620), Expect = 1e-64, Method: Composition-based stats. Identities = 73/314 (23%), Positives = 133/314 (42%), Gaps = 43/314 (13%) Query: 54 VSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQI-MRKLDHCNIVRL 112 Y + IG GS+ V + + A+K + + KR E++I +R H NI+ L Sbjct: 35 DGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITL 94 Query: 113 RYFFYSSGEKKDEVYLNLVLDYV--PETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLA 170 + + D Y+ +V + + E + ++ R ++ ++ + +++ Sbjct: 95 KDVY------DDGKYVYVVTELMKGGELLDKILR-----QKFFSEREASAVLFTITKTVE 143 Query: 171 YIHSFGICHRDIKPQNLLLDPDTA---VLKLCDFGSAKQL-VRGEPNVSYICSRYYRAPE 226 Y+H+ G+ HRD+KP N+L ++ +++CDFG AKQL ++ + + APE Sbjct: 144 YLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPE 203 Query: 227 LIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNP 286 ++ Y ++ D+WS G +L +L G F + D EI+ +G+ Sbjct: 204 VLE-RQGYDAACDIWSLGVLLYTMLTGYTPF-ANGPDDTPEEILARIGSGKF-------- 253 Query: 287 NYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDEL-RD 345 + W V A L S++L P RLT H + + Sbjct: 254 --------SLSGGYWNSV-----SDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQL 300 Query: 346 PNVKLPNGRDTPAL 359 P +L N +D P L Sbjct: 301 PQYQL-NRQDAPHL 313 >1ZWS-A nrPDB Length = 288 Score = 243 bits (620), Expect = 1e-64, Method: Composition-based stats. Identities = 68/314 (21%), Positives = 125/314 (39%), Gaps = 50/314 (15%) Query: 45 GQGPDRPQEVS--YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ----------DKR 92 G P + Q+V Y + +G+G F +V + + +G A K + + + Sbjct: 1 GMEPFKQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSRE 60 Query: 93 FKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQT 152 RE+ I+R++ H N++ L + + + + L+L+ V + K++ Sbjct: 61 EIEREVSILRQVLHHNVITLHDVYENRTD------VVLILELVSGGELF---DFLAQKES 111 Query: 153 LPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLL---DPDTAVLKLCDFGSAKQLVR 209 L ++ Q+ + Y+H+ I H D+KP+N++L + +KL DFG A ++ Sbjct: 112 LSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIED 171 Query: 210 GEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEI 269 G + + + APE++ D+WS G + LL G F GD+ + L I Sbjct: 172 GVEFKNIFGTPEFVAPEIV-NYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANI 230 Query: 270 IKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARL 329 V ++ + + F T A +LL RL Sbjct: 231 TSV-------------------------SYDFDEEFFSHTSELAKDFIRKLLVKETRKRL 265 Query: 330 TPLEACAHSFFDEL 343 T EA H + + Sbjct: 266 TIQEALRHPWITPV 279 >4CFH-A nrPDB Length = 493 Score = 243 bits (620), Expect = 1e-64, Method: Composition-based stats. Identities = 72/301 (23%), Positives = 115/301 (38%), Gaps = 46/301 (15%) Query: 49 DRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKR-------FKNRELQIM 101 R + Y +G G+FG V K +G VA+K + + K RE+Q + Sbjct: 28 GRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNL 87 Query: 102 RKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLY 161 + H +I++L + + + +V++YV Y L + Sbjct: 88 KLFRHPHIIKLYQVISTPSD------IFMVMEYVSGGELF---DYICKNGRLDEKESRRL 138 Query: 162 MYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY 221 Q+ + Y H + HRD+KP+N+LLD K+ DFG + + GE + S Sbjct: 139 FQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNA-KIADFGLSNMMSDGEFLRTSCGSPN 197 Query: 222 YRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQI 281 Y APE+I G +D+WS+G +L LL G F D +I + Sbjct: 198 YAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGI-------- 249 Query: 282 REMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFD 341 F PQ P I+L +L+ P R T + H +F Sbjct: 250 ---------FYTPQY------------LNPSVISLLKHMLQVDPMKRATIKDIREHEWFK 288 Query: 342 E 342 + Sbjct: 289 Q 289 >3D2K-A nrPDB Length = 272 Score = 243 bits (619), Expect = 2e-64, Method: Composition-based stats. Identities = 84/295 (28%), Positives = 127/295 (43%), Gaps = 50/295 (16%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFK-------NRELQIMRKLDHC 107 + + +G G FG VY A+ S ++A+K + + + K RE++I L H Sbjct: 13 DFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVEHQLRREVEIQSHLRHP 72 Query: 108 NIVRLRYFFYSSGEKKDEVYLNLVLDYVP-ETVYRVARHYSRAKQTLPVIYVKLYMYQLF 166 NI+RL +F+ D + L+L+Y P TVYR + SR Y+ +L Sbjct: 73 NILRLYGYFH------DATRVYLILEYAPLGTVYRELQKLSR----FDEQRTATYITELA 122 Query: 167 RSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPE 226 +L+Y HS + HRDIKP+NLLL + LK+ DFG + + + Y PE Sbjct: 123 NALSYCHSKRVIHRDIKPENLLLGSNGE-LKIADFGWSVH-APSSRRTTLCGTLDYLPPE 180 Query: 227 LIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNP 286 +I G + +D+WS G + E L+G P F + + I +V Sbjct: 181 MIEGRM-HDEKVDLWSLGVLCYEFLVGMPPFEAHTYQETYRRISRV-------------- 225 Query: 287 NYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFD 341 EF FP A L SRLL++ + RLT E H + Sbjct: 226 ---EFTFPDF------------VTEGARDLISRLLKHNASQRLTLAEVLEHPWIK 265 >4REW-A nrPDB Length = 540 Score = 242 bits (618), Expect = 2e-64, Method: Composition-based stats. Identities = 70/298 (23%), Positives = 114/298 (38%), Gaps = 46/298 (15%) Query: 52 QEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKR-------FKNRELQIMRKL 104 + Y +G G+FG V K +G VA+K + + K RE+Q ++ Sbjct: 4 KIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLF 63 Query: 105 DHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQ 164 H +I++L + + + +V++YV Y L + Q Sbjct: 64 RHPHIIKLYQVISTPSD------IFMVMEYVSGGELF---DYICKNGRLDEKESRRLFQQ 114 Query: 165 LFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRA 224 + + Y H + HRD+KP+N+LLD K+ DFG + + GE + S Y A Sbjct: 115 ILSGVDYCHRHMVVHRDLKPENVLLDAHMNA-KIADFGLSNMMSDGEFLRTSCGSPNYAA 173 Query: 225 PELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREM 284 PE+I G +D+WS+G +L LL G F D +I + Sbjct: 174 PEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGI----------- 222 Query: 285 NPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDE 342 F PQ P I+L +L+ P R + + H +F + Sbjct: 223 ------FYTPQY------------LNPSVISLLKHMLQVDPMKRASIKDIREHEWFKQ 262 >4RED-A nrPDB Length = 351 Score = 242 bits (617), Expect = 3e-64, Method: Composition-based stats. Identities = 70/298 (23%), Positives = 114/298 (38%), Gaps = 46/298 (15%) Query: 52 QEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKR-------FKNRELQIMRKL 104 + Y +G G+FG V K +G VA+K + + K RE+Q ++ Sbjct: 12 KIGHYILGDTLGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVVGKIRREIQNLKLF 71 Query: 105 DHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQ 164 H +I++L + + + +V++YV Y L + Q Sbjct: 72 RHPHIIKLYQVISTPSD------IFMVMEYVSGGELF---DYICKNGRLDEKESRRLFQQ 122 Query: 165 LFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRA 224 + + Y H + HRD+KP+N+LLD K+ DFG + + GE + S Y A Sbjct: 123 ILSGVDYCHRHMVVHRDLKPENVLLDAHMNA-KIADFGLSNMMSDGEFLRTSCGSPNYAA 181 Query: 225 PELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREM 284 PE+I G +D+WS+G +L LL G F D +I + Sbjct: 182 PEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGI----------- 230 Query: 285 NPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDE 342 F PQ P I+L +L+ P R + + H +F + Sbjct: 231 ------FYTPQY------------LNPSVISLLKHMLQVDPMKRASIKDIREHEWFKQ 270 >4RA4-A nrPDB Length = 355 Score = 242 bits (617), Expect = 3e-64, Method: Composition-based stats. Identities = 82/367 (22%), Positives = 141/367 (38%), Gaps = 71/367 (19%) Query: 44 PGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNR------- 96 P DR + + V+G GSFG V A + EL AIK + +D ++ Sbjct: 10 PSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMV 69 Query: 97 ELQIMRKLDHC-NIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPV 155 E +++ LD + +L F + L V++YV ++ + Sbjct: 70 EKRVLALLDKPPFLTQLHSCFQTVDR------LYFVMEYVNGG---DLMYHIQQVGKFKE 120 Query: 156 IYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAK-QLVRGEPNV 214 Y ++ L ++H GI +RD+K N++LD + +K+ DFG K ++ G Sbjct: 121 PQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGH-IKIADFGMCKEHMMDGVTTR 179 Query: 215 SYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLG 274 ++ + Y APE+I Y S+D W+ G +L E+L GQP F G+ + I++ Sbjct: 180 TFCGTPDYIAPEII-AYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIME--- 235 Query: 275 TPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTP--- 331 +P+ EA+++C L+ P RL Sbjct: 236 --------------HNVSYPK------------SLSKEAVSICKGLMTKHPAKRLGCGPE 269 Query: 332 --LEACAHSFF----------DELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIP 379 + H+FF E++ P +G+ F T+ +L P Sbjct: 270 GERDVREHAFFRRIDWEKLENREIQPPFKPKVSGKGAENFDKFFTRG-------QPVLTP 322 Query: 380 PHARIQA 386 P + A Sbjct: 323 PDQLVIA 329 >2JDO-A nrPDB Length = 342 Score = 241 bits (615), Expect = 5e-64, Method: Composition-based stats. Identities = 81/343 (23%), Positives = 144/343 (41%), Gaps = 65/343 (18%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNREL-------QIMRKLDHC 107 + K++G G+FG V + +G A+K + ++ E+ ++++ H Sbjct: 11 DFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHP 70 Query: 108 NIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFR 167 + L+Y F + L V++Y + H SR ++ + Y ++ Sbjct: 71 FLTALKYAFQTHDR------LCFVMEYANGG--ELFFHLSR-ERVFTEERARFYGAEIVS 121 Query: 168 SLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ-LVRGEPNVSYICSRYYRAPE 226 +L Y+HS + +RDIK +NL+LD D +K+ DFG K+ + G ++ + Y APE Sbjct: 122 ALEYLHSRDVVYRDIKLENLMLDKDGH-IKITDFGLCKEGISDGATMKTFCGTPEYLAPE 180 Query: 227 LIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNP 286 ++ DY ++D W G V+ E++ G+ F ++L E+I + Sbjct: 181 VLED-NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDH-ERLFELILM-------------- 224 Query: 287 NYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARL-----TPLEACAHSFF- 340 E +FP+ PEA +L + LL+ P RL E H FF Sbjct: 225 --EEIRFPRT------------LSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFL 270 Query: 341 ---------DELRDP-NVKLPNGRDTPALFN-FTTQELSSNPP 372 +L P ++ + DT + FT Q ++ PP Sbjct: 271 SINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSITITPP 313 >4LG4-A nrPDB Length = 299 Score = 241 bits (615), Expect = 5e-64, Method: Composition-based stats. Identities = 67/296 (22%), Positives = 119/296 (40%), Gaps = 40/296 (13%) Query: 49 DRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN--RELQIMRKLDH 106 +P+EV + + +G GS+G V++A +SG++VAIK+V + + +E+ IM++ D Sbjct: 7 KQPEEV-FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDS 65 Query: 107 CNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLF 166 +V+ ++ + + L +V++Y +TL + + Sbjct: 66 PYVVKYYGSYFKNTD------LWIVMEYCGAGSVSDIIRLR--NKTLIEDEIATILKSTL 117 Query: 167 RSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNV-SYICSRYYRAP 225 + L Y+H HR+IK N+LL+ + KL DFG A QL + I + ++ AP Sbjct: 118 KGLEYLHFMRKIHRNIKAGNILLNTEGHA-KLADFGVAGQLTDTMAKRNTVIGTPFWMAP 176 Query: 226 ELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMN 285 E+I Y D+WS G E+ G+P + + + I Sbjct: 177 EVI-QEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMI---------------- 219 Query: 286 PNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFD 341 P F + + W + + L P R T + H F Sbjct: 220 PTNPPPTFRKPEL--W--------SDDFTDFVKKCLVKNPEQRATATQLLQHPFIK 265 >2F57-A nrPDB Length = 317 Score = 241 bits (615), Expect = 5e-64, Method: Composition-based stats. Identities = 80/336 (23%), Positives = 141/336 (41%), Gaps = 50/336 (14%) Query: 22 AFGSM-KVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGE 80 F SM +VS ++ + + VV+ P P+E K IG GS G+V A +G+ Sbjct: 18 YFQSMSRVSHEQFRAALQLVVS-----PGDPREYLANFIK-IGEGSTGIVCIATEKHTGK 71 Query: 81 LVAIKKVLQDKRFKNR----ELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVP 136 VA+KK+ K+ + E+ IMR H N+V + + E L +V++++ Sbjct: 72 QVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDE------LWVVMEFLE 125 Query: 137 ETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVL 196 ++R + + + R+L+Y+H+ G+ HRDIK ++LL D + Sbjct: 126 GGALTDIVTHTR----MNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSD-GRI 180 Query: 197 KLCDFGSAKQLVRGEPN-VSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQP 255 KL DFG Q+ + P S + + Y+ APE+I Y + +D+WS G ++ E++ G+P Sbjct: 181 KLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVI-SRLPYGTEVDIWSLGIMVIEMIDGEP 239 Query: 256 IFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIA 315 + + + + I L ++ + Sbjct: 240 PYFNEPPLQAMRRIRDSLPPRVKDL--------------------------HKVSSVLRG 273 Query: 316 LCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLP 351 +L P+ R T E H F P+ +P Sbjct: 274 FLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVP 309 >2W4O-A nrPDB Length = 349 Score = 240 bits (613), Expect = 7e-64, Method: Composition-based stats. Identities = 74/288 (25%), Positives = 118/288 (40%), Gaps = 38/288 (13%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ--DKRFKNRELQIMRKLDHCNIVRLR 113 + +G G+ +VY+ K + + A+K + + DK+ E+ ++ +L H NI++L+ Sbjct: 55 FEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKIVRTEIGVLLRLSHPNIIKLK 114 Query: 114 YFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIH 173 F E E+ L L L E R+ K + Q+ ++AY+H Sbjct: 115 EIF----ETPTEISLVLELVTGGELFDRIVE-----KGYYSERDAADAVKQILEAVAYLH 165 Query: 174 SFGICHRDIKPQNLLLDP--DTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGA 231 GI HRD+KP+NLL A LK+ DFG +K + + + Y APE++ G Sbjct: 166 ENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGC 225 Query: 232 TDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEF 291 Y +D+WS G + LL G F + G + R +N Y Sbjct: 226 A-YGPEVDMWSVGIITYILLCGFEPFYDERGDQFMFR-------------RILNCEYYFI 271 Query: 292 KFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSF 339 PW A L +L+ P RLT +A H + Sbjct: 272 S-------PW----WDEVSLNAKDLVRKLIVLDPKKRLTTFQALQHPW 308 >4J52-A nrPDB Length = 293 Score = 240 bits (613), Expect = 7e-64, Method: Composition-based stats. Identities = 78/334 (23%), Positives = 131/334 (39%), Gaps = 70/334 (20%) Query: 62 IGNGSFGVVYQAKLCDSGELVAIKKVLQD-------KRFKNRELQIMRKLDHCNIVRLRY 114 +G G F ++ D+ E+ A K V + + + E+ I R L H ++V Sbjct: 22 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 81 Query: 115 FFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHS 174 FF +D ++ +VL+ R + ++ L + Y+ Q+ Y+H Sbjct: 82 FF------EDNDFVFVVLELCR---RRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHR 132 Query: 175 FGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQL-VRGEPNVSYICSRYYRAPELIFGATD 233 + HRD+K NL L+ D V K+ DFG A ++ GE + Y APE++ Sbjct: 133 NRVIHRDLKLGNLFLNEDLEV-KIGDFGLATKVEYDGERKKVLCGTPNYIAPEVL-SKKG 190 Query: 234 YTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKF 293 ++ +DVWS GC++ LL+G+P F + + I K E+ Sbjct: 191 HSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKK-----------------NEYSI 233 Query: 294 PQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNG 353 P+ P A +L ++L+ PTAR T E FF Sbjct: 234 PK------------HINPVAASLIQKMLQTDPTARPTINELLNDEFF------------- 268 Query: 354 RDTPALFNFTTQELSSNPPLATILIPPHARIQAA 387 T+ + + P+ + IPP I + Sbjct: 269 ---------TSGYIPARLPITCLTIPPRFSIAPS 293 >4JXF-A nrPDB Length = 266 Score = 240 bits (613), Expect = 7e-64, Method: Composition-based stats. Identities = 77/298 (25%), Positives = 129/298 (43%), Gaps = 47/298 (15%) Query: 52 QEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFK-------NRELQIMRKL 104 + + ++G GSF VY+A+ +G VAIK + + +K E++I +L Sbjct: 5 KIEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQL 64 Query: 105 DHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQ 164 H +I+ L +F E + VYL L + + E + R+ + + +M+Q Sbjct: 65 KHPSILELYNYF----EDSNYVYLVLEMCHNGE----MNRYLKNRVKPFSENEARHFMHQ 116 Query: 165 LFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQL-VRGEPNVSYICSRYYR 223 + + Y+HS GI HRD+ NLLL + +K+ DFG A QL + E + + + Y Sbjct: 117 IITGMLYLHSHGILHRDLTLSNLLLTRNMN-IKIADFGLATQLKMPHEKHYTLCGTPNYI 175 Query: 224 APELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIRE 283 +PE I + + DVWS GC+ LL+G+P F D+ + L +++ Sbjct: 176 SPE-IATRSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVV------------- 221 Query: 284 MNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFD 341 +++ P EA L +LL P RL+ H F Sbjct: 222 ----LADYEMPSF------------LSIEAKDLIHQLLRRNPADRLSLSSVLDHPFMS 263 >2YZA-A nrPDB Length = 276 Score = 240 bits (612), Expect = 1e-63, Method: Composition-based stats. Identities = 69/305 (22%), Positives = 114/305 (37%), Gaps = 46/305 (15%) Query: 45 GQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKR-------FKNRE 97 + R + Y +G G+FG V + +G VA+K + + K RE Sbjct: 2 SKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKRE 61 Query: 98 LQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIY 157 +Q ++ H +I++L + + +V++YV Y + + Sbjct: 62 IQNLKLFRHPHIIKLYQVISTPTD------FFMVMEYVSGGELF---DYICKHGRVEEME 112 Query: 158 VKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYI 217 + Q+ ++ Y H + HRD+KP+N+LLD K+ DFG + + GE Sbjct: 113 ARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNA-KIADFGLSNMMSDGEFLRDSC 171 Query: 218 CSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPT 277 S Y APE+I G +D+WS G +L LL G F D V L + I+ Sbjct: 172 GSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFD-DEHVPTLFKKIRG----- 225 Query: 278 REQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAH 337 F P+ L +L+ P R T + H Sbjct: 226 -----------GVFYIPEYLNRSVAT------------LLMHMLQVDPLKRATIKDIREH 262 Query: 338 SFFDE 342 +F + Sbjct: 263 EWFKQ 267 >4UZD-A nrPDB Length = 287 Score = 239 bits (611), Expect = 1e-63, Method: Composition-based stats. Identities = 82/294 (27%), Positives = 127/294 (43%), Gaps = 50/294 (17%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFK-------NRELQIMRKLDHC 107 + + +G G FG VY A+ S ++A+K + + + K RE++I L H Sbjct: 9 DFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHP 68 Query: 108 NIVRLRYFFYSSGEKKDEVYLNLVLDYVP-ETVYRVARHYSRAKQTLPVIYVKLYMYQLF 166 NI+RL +F+ D + L+L+Y P TVYR + S+ Y+ +L Sbjct: 69 NILRLYGYFH------DATRVYLILEYAPLGTVYRELQKLSK----FDEQRTATYITELA 118 Query: 167 RSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPE 226 +L+Y HS + HRDIKP+NLLL LK+ DFG + + + Y PE Sbjct: 119 NALSYCHSKRVIHRDIKPENLLLGS-AGELKIADFGWSVH-APSSRRTTLCGTLDYLPPE 176 Query: 227 LIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNP 286 +I G + +D+WS G + E L+G+P F ++ + I +V Sbjct: 177 MIEGRM-HDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRV-------------- 221 Query: 287 NYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF 340 EF FP A L SRLL++ P+ R E H + Sbjct: 222 ---EFTFPDF------------VTEGARDLISRLLKHNPSQRPMLREVLEHPWI 260 >6AO5-A nrPDB Length = 362 Score = 239 bits (610), Expect = 1e-63, Method: Composition-based stats. Identities = 67/296 (22%), Positives = 119/296 (40%), Gaps = 40/296 (13%) Query: 49 DRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN--RELQIMRKLDH 106 +P+EV + + +G GS+G V++A +SG++VAIK+V + + +E+ IM++ D Sbjct: 6 KQPEEV-FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDS 64 Query: 107 CNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLF 166 +V+ ++ + + L +V++Y +TL + + Sbjct: 65 PYVVKYYGSYFKNTD------LWIVMEYCGAGSVSDIIRLR--NKTLIEDEIATILKSTL 116 Query: 167 RSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNV-SYICSRYYRAP 225 + L Y+H HR+IK N+LL+ + KL DFG A QL + I + ++ AP Sbjct: 117 KGLEYLHFMRKIHRNIKAGNILLNTEGHA-KLADFGVAGQLTDTMAKRNTVIGTPFWMAP 175 Query: 226 ELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMN 285 E+I Y D+WS G E+ G+P + + + I Sbjct: 176 EVI-QEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMI---------------- 218 Query: 286 PNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFD 341 P F + + W + + L P R T + H F Sbjct: 219 PTNPPPTFRKPEL--W--------SDDFTDFVKKCLVKNPEQRATATQLLQHPFIK 264 >4CFF-A nrPDB Length = 571 Score = 239 bits (610), Expect = 2e-63, Method: Composition-based stats. Identities = 69/301 (22%), Positives = 114/301 (37%), Gaps = 46/301 (15%) Query: 49 DRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKR-------FKNRELQIM 101 R + Y +G G+FG V + +G VA+K + + K RE+Q + Sbjct: 28 GRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNL 87 Query: 102 RKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLY 161 + H +I++L + + +V++YV Y + + + Sbjct: 88 KLFRHPHIIKLYQVISTPTD------FFMVMEYVSGGELF---DYICKHGRVEEMEARRL 138 Query: 162 MYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY 221 Q+ ++ Y H + HRD+KP+N+LLD K+ DFG + + GE + S Sbjct: 139 FQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNA-KIADFGLSNMMSDGEFLRTSCGSPN 197 Query: 222 YRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQI 281 Y APE+I G +D+WS G +L LL G F D V L + I+ Sbjct: 198 YAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFD-DEHVPTLFKKIRG--------- 247 Query: 282 REMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFD 341 F P+ L +L+ P R T + H +F Sbjct: 248 -------GVFYIPEYLNRSVAT------------LLMHMLQVDPLKRATIKDIREHEWFK 288 Query: 342 E 342 + Sbjct: 289 Q 289 >5EZV-A nrPDB Length = 560 Score = 239 bits (610), Expect = 2e-63, Method: Composition-based stats. Identities = 69/301 (22%), Positives = 114/301 (37%), Gaps = 46/301 (15%) Query: 49 DRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKR-------FKNRELQIM 101 R + Y +G G+FG V + +G VA+K + + K RE+Q + Sbjct: 23 GRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNL 82 Query: 102 RKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLY 161 + H +I++L + + +V++YV Y + + + Sbjct: 83 KLFRHPHIIKLYQVISTPTD------FFMVMEYVSGGELF---DYICKHGRVEEMEARRL 133 Query: 162 MYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY 221 Q+ ++ Y H + HRD+KP+N+LLD K+ DFG + + GE + S Sbjct: 134 FQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNA-KIADFGLSNMMSDGEFLRTSCGSPN 192 Query: 222 YRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQI 281 Y APE+I G +D+WS G +L LL G F D V L + I+ Sbjct: 193 YAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFD-DEHVPTLFKKIRG--------- 242 Query: 282 REMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFD 341 F P+ L +L+ P R T + H +F Sbjct: 243 -------GVFYIPEYLNRSVAT------------LLMHMLQVDPLKRATIKDIREHEWFK 283 Query: 342 E 342 + Sbjct: 284 Q 284 >3GUB-A nrPDB Length = 295 Score = 239 bits (610), Expect = 2e-63, Method: Composition-based stats. Identities = 63/320 (19%), Positives = 122/320 (38%), Gaps = 49/320 (15%) Query: 53 EVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ----------DKRFKNRELQIMR 102 + Y + +G+G F VV + + +G A K + + + RE+ I++ Sbjct: 10 DDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILK 69 Query: 103 KLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYM 162 ++ H N++ L + + + + L+ + V + K++L ++ Sbjct: 70 EIQHPNVITLHEVYENKTD------VILIGELVAGGELF---DFLAEKESLTEEEATEFL 120 Query: 163 YQLFRSLAYIHSFGICHRDIKPQNLLL---DPDTAVLKLCDFGSAKQLVRGEPNVSYICS 219 Q+ + Y+HS I H D+KP+N++L + +K+ DFG A ++ G + + Sbjct: 121 KQILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGT 180 Query: 220 RYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTRE 279 + APE++ D+WS G + LL G F GD+ + L + V Sbjct: 181 PEFVAPEIV-NYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAV------- 232 Query: 280 QIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSF 339 + + + T A RLL P R+T ++ H + Sbjct: 233 ------------------NYEFEDEYFSNTSALAKDFIRRLLVKDPKKRMTIQDSLQHPW 274 Query: 340 FDELRDPNVKLPNGRDTPAL 359 +D L + P Sbjct: 275 IKP-KDTQQALSSAWSHPQF 293 >2HAK-A nrPDB Length = 328 Score = 239 bits (610), Expect = 2e-63, Method: Composition-based stats. Identities = 72/318 (22%), Positives = 123/318 (38%), Gaps = 47/318 (14%) Query: 49 DRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ------DKRFKNRELQIMR 102 ++P +Y K IG G+F V A+ +G VA+K + + + RE++IM+ Sbjct: 10 EQPHIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMK 69 Query: 103 KLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPET-VYRVARHYSRAKQTLPVIYVKLY 161 L+H NIV+L + E L LV++Y V+ + R K + Sbjct: 70 ILNHPNIVKLFEVI------ETEKTLYLVMEYASGGEVFDYLVAHGRMK----EKEARAK 119 Query: 162 MYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY 221 Q+ ++ Y H I HRD+K +NLLLD D +K+ DFG + + G ++ S Sbjct: 120 FRQIVSAVQYCHQKYIVHRDLKAENLLLDGDMN-IKIADFGFSNEFTVGNKLDTFCGSPP 178 Query: 222 YRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQI 281 Y APEL G +DVWS G +L L+ G F G + + +++ Sbjct: 179 YAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLR---------- 228 Query: 282 REMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFD 341 +++ P + + + P R + + + + Sbjct: 229 -------GKYRIPFYMSTDCENLLKKLLVLN------------PIKRGSLEQIMKDRWMN 269 Query: 342 ELRDPNVKLPNGRDTPAL 359 + P P Sbjct: 270 VGHEEEELKPYTEPDPDF 287 >5KCV-A nrPDB Length = 460 Score = 239 bits (609), Expect = 2e-63, Method: Composition-based stats. Identities = 80/387 (20%), Positives = 143/387 (36%), Gaps = 85/387 (21%) Query: 2 SGRPRTTSFAESCK----------PVQQPSAFGSMKVS--------RDKDGSKVTTVVAT 43 + RPR +F C V+ P + + + +++ + Sbjct: 79 TERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQAAAEMDFRSGS 138 Query: 44 PGQGP-------------DRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQD 90 P R + K++G G+FG V K +G A+K + ++ Sbjct: 139 PSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKE 198 Query: 91 KRFKNREL-------QIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVA 143 E+ ++++ H + L+Y F + L V++Y + Sbjct: 199 VIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDR------LCFVMEYANGG--ELF 250 Query: 144 RHYSRAKQTLPVIYVKLYMYQLFRSLAYIHS-FGICHRDIKPQNLLLDPDTAVLKLCDFG 202 H SR ++ + Y ++ +L Y+HS + +RD+K +NL+LD D +K+ DFG Sbjct: 251 FHLSR-ERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGH-IKITDFG 308 Query: 203 SAKQ-LVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDS 261 K+ + G ++ + Y APE++ DY ++D W G V+ E++ G+ F Sbjct: 309 LCKEGIKDGATMKTFCGTPEYLAPEVLED-NDYGRAVDWWGLGVVMYEMMCGRLPFYNQD 367 Query: 262 GVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLL 321 I+ E +FP+ PEA +L S LL Sbjct: 368 HEKLFELIL-----------------MEEIRFPRTLG------------PEAKSLLSGLL 398 Query: 322 EYTPTARL-----TPLEACAHSFFDEL 343 + P RL E H FF + Sbjct: 399 KKDPKQRLGGGSEDAKEIMQHRFFAGI 425 >2ZMD-A nrPDB Length = 390 Score = 238 bits (608), Expect = 3e-63, Method: Composition-based stats. Identities = 83/373 (22%), Positives = 147/373 (39%), Gaps = 62/373 (16%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN------RELQIMRKLDHCN- 108 Y+ K IG+G V+Q L + ++ AIK V ++ E+ + KL + Sbjct: 58 YSILKQIGSGGSSKVFQV-LNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 116 Query: 109 -IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFR 167 I+RL + + + Y+ +V++ + + + K+++ K Y + Sbjct: 117 KIIRLYDY------EITDQYIYMVMECGNIDL----NSWLKKKKSIDPWERKSYWKNMLE 166 Query: 168 SLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNV---SYICSRYYRA 224 ++ IH GI H D+KP N L+ +LKL DFG A Q+ +V S + + Y Sbjct: 167 AVHTIHQHGIVHSDLKPANFLIV--DGMLKLIDFGIANQMQPDTTSVVKDSQVGAVNYMP 224 Query: 225 PELIFG----------ATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLG 274 PE I + + DVWS GC+L + G+ F Q++ I L Sbjct: 225 PEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF------QQIINQISKLH 278 Query: 275 TPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEA 334 ++PN+ E +FP I + L+ P R++ E Sbjct: 279 AI-------IDPNH-EIEFPDIPEKDLQ------------DVLKCCLKRDPKQRISIPEL 318 Query: 335 CAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASPPANA 394 AH + P ++ G T + Q + N P +IL + + ++ Sbjct: 319 LAHPYVQIQTHPVNQMAKGT-TEEMKYVLGQLVGLNSP-NSILKAAKTLYEHYSGGESHN 376 Query: 395 TAASDTNAGDRGQ 407 +++S T RG+ Sbjct: 377 SSSSKTFEKKRGK 389 >5D7A-A nrPDB Length = 308 Score = 238 bits (608), Expect = 3e-63, Method: Composition-based stats. Identities = 68/300 (22%), Positives = 122/300 (40%), Gaps = 38/300 (12%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVL---QDKRFKNRELQIMRKLDHC-NIVR 111 + +++GNG++G VY+ + +G+L AIK + ++ +E+ +++K H NI Sbjct: 19 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIAT 78 Query: 112 LRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAY 171 F + L LV+++ ++ TL ++ ++ R L++ Sbjct: 79 YYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKG-NTLKEEWIAYICREILRGLSH 137 Query: 172 IHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRG-EPNVSYICSRYYRAPELIFG 230 +H + HRDIK QN+LL + V KL DFG + QL R ++I + Y+ APE+I Sbjct: 138 LHQHKVIHRDIKGQNVLLTENAEV-KLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIAC 196 Query: 231 ATD----YTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNP 286 + Y D+WS G E+ G P + L I Sbjct: 197 DENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLI----------------- 239 Query: 287 NYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDP 346 P++K+ W+K F+ + L + R + H F + + Sbjct: 240 --PRNPAPRLKSKKWSKKFQ--------SFIESCLVKNHSQRPATEQLMKHPFIRDQPNE 289 >4RLP-A nrPDB Length = 288 Score = 238 bits (607), Expect = 3e-63, Method: Composition-based stats. Identities = 70/315 (22%), Positives = 131/315 (41%), Gaps = 57/315 (18%) Query: 50 RPQEVSYTDTKVIGNGSFGVVYQAKLC---DSGELVAIKKVLQ--------DKRFKNREL 98 + + + +V+G G +G V+Q + ++G++ A+K + + D E Sbjct: 1 KIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAER 60 Query: 99 QIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYV 158 I+ ++ H IV L Y F + G+ L L+L+Y+ + + Sbjct: 61 NILEEVKHPFIVDLIYAFQTGGK------LYLILEYLSGGELFMQL---EREGIFMEDTA 111 Query: 159 KLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ-LVRGEPNVSYI 217 Y+ ++ +L ++H GI +RD+KP+N++L+ V KL DFG K+ + G ++ Sbjct: 112 CFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHV-KLTDFGLCKESIHDGTVTHTFC 170 Query: 218 CSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPT 277 + Y APE++ + + ++D WS G ++ ++L G P F G++ + +I+K Sbjct: 171 GTIEYMAPEILM-RSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKC----- 224 Query: 278 REQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARL-----TPL 332 P EA L +LL+ +RL Sbjct: 225 ------------------------KLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAG 260 Query: 333 EACAHSFFDELRDPN 347 E AH FF + Sbjct: 261 EVQAHPFFRHINWEE 275 >3DB8-A nrPDB Length = 317 Score = 238 bits (607), Expect = 4e-63, Method: Composition-based stats. Identities = 88/387 (22%), Positives = 146/387 (37%), Gaps = 79/387 (20%) Query: 5 PRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGN 64 P + A KP +PSA K + K+ P D Y + +G Sbjct: 2 PLGSMSAAIAKPSAKPSAHVDPKSAPLKE---------IPDVLVDPRTMKRYMRGRFLGK 52 Query: 65 GSFGVVYQAKLCDSGELVAIKKVLQD-------KRFKNRELQIMRKLDHCNIVRLRYFFY 117 G F Y+ D+ E+ A K V + K + E+ I + LD+ ++V FF Sbjct: 53 GGFAKCYEITDMDTKEVFAGKVVPKSMLLKPHQKEKMSTEIAIHKSLDNPHVVGFHGFF- 111 Query: 118 SSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGI 177 +D+ ++ +VL+ R + ++ + + +M Q + + Y+H+ + Sbjct: 112 -----EDDDFVYVVLEICR---RRSLLELHKRRKAVTEPEARYFMRQTIQGVQYLHNNRV 163 Query: 178 CHRDIKPQNLLLDPDTAVLKLCDFGSAKQLV-RGEPNVSYICSRYYRAPELIFGATDYTS 236 HRD+K NL L+ D V K+ DFG A ++ GE + Y APE++ ++ Sbjct: 164 IHRDLKLGNLFLNDDMDV-KIGDFGLATKIEFDGERKKDLCGTPNYIAPEVL-CKKGHSF 221 Query: 237 SIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQI 296 +D+WS GC+L LL+G+P F + + I K E+ P+ Sbjct: 222 EVDIWSLGCILYTLLVGKPPFETSCLKETYIRIKK-----------------NEYSVPR- 263 Query: 297 KAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDT 356 P A AL R+L PT R + E FF Sbjct: 264 -----------HINPVASALIRRMLHADPTLRPSVAELLTDEFF---------------- 296 Query: 357 PALFNFTTQELSSNPPLATILIPPHAR 383 T+ P + + +PP Sbjct: 297 ------TSGYAPMRLPTSCLTVPPRFS 317 >3MV5-A nrPDB Length = 342 Score = 238 bits (607), Expect = 4e-63, Method: Composition-based stats. Identities = 80/344 (23%), Positives = 138/344 (40%), Gaps = 66/344 (19%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNREL-------QIMRKLDHC 107 + K++G G+FG V K +G A+K + ++ E+ ++++ H Sbjct: 11 EFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHP 70 Query: 108 NIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFR 167 + L+Y F + L V++Y + H SR ++ + Y ++ Sbjct: 71 FLTALKYSFQTHDR------LCFVMEYANGG--ELFFHLSR-ERVFSEDRARFYGAEIVS 121 Query: 168 SLAYIHS-FGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ-LVRGEPNVSYICSRYYRAP 225 +L Y+HS + +RD+K +NL+LD D +K+ DFG K+ + G ++ + Y AP Sbjct: 122 ALDYLHSEKNVVYRDLKLENLMLDKDGH-IKITDFGLCKEGIKDGATMKTFCGTPEYLAP 180 Query: 226 ELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMN 285 E++ DY ++D W G V+ E++ G+ F I+ Sbjct: 181 EVLED-NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL--------------- 224 Query: 286 PNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARL-----TPLEACAHSFF 340 E +FP+ PEA +L S LL+ P RL E H FF Sbjct: 225 --MEEIRFPRTLG------------PEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFF 270 Query: 341 ----------DELRDP-NVKLPNGRDTPALF-NFTTQELSSNPP 372 +L P ++ + DT FT Q ++ PP Sbjct: 271 AGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPP 314 >2Y7J-A nrPDB Length = 365 Score = 238 bits (606), Expect = 5e-63, Method: Composition-based stats. Identities = 78/318 (24%), Positives = 125/318 (39%), Gaps = 53/318 (16%) Query: 42 ATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVL------------Q 89 P + Y VIG G VV + +G A+K + + Sbjct: 82 ELPDWAAAKEFYQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEE 141 Query: 90 DKRFKNRELQIMRKL-DHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSR 148 + RE I+R++ H +I+ L + SS ++ LV D + + Y Sbjct: 142 VREATRRETHILRQVAGHPHIITLIDSYESS------SFMFLVFDLMRKGELF---DYLT 192 Query: 149 AKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLV 208 K L + M L +++++H+ I HRD+KP+N+LLD D ++L DFG + L Sbjct: 193 EKVALSEKETRSIMRSLLEAVSFLHANNIVHRDLKPENILLD-DNMQIRLSDFGFSCHLE 251 Query: 209 RGEPNVSYICSRYYRAPELI-----FGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGV 263 GE + Y APE++ Y +D+W+ G +L LL G P F + Sbjct: 252 PGEKLRELCGTPGYLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQI 311 Query: 264 DQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEY 323 L I++ +++F + L SRLL+ Sbjct: 312 LMLRMIME-----------------GQYQFSSPE--------WDDRSSTVKDLISRLLQV 346 Query: 324 TPTARLTPLEACAHSFFD 341 P ARLT +A H FF+ Sbjct: 347 DPEARLTAEQALQHPFFE 364 >4KS7-A nrPDB Length = 292 Score = 238 bits (606), Expect = 5e-63, Method: Composition-based stats. Identities = 82/330 (24%), Positives = 135/330 (40%), Gaps = 49/330 (14%) Query: 27 KVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKK 86 V+ ++ + + VV QG R SY IG GS G+V A+ SG VA+K Sbjct: 2 SVTHEQFKAALRMVVD---QGDPRLLLDSYV---KIGEGSTGIVCLAREKHSGRQVAVKM 55 Query: 87 VLQDKRFKNR----ELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRV 142 + K+ + E+ IMR H N+V + + E L ++++++ Sbjct: 56 MDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYLVGEE------LWVLMEFLQGGALTD 109 Query: 143 ARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFG 202 R L + + ++LAY+H+ G+ HRDIK ++LL D V KL DFG Sbjct: 110 IVSQVR----LNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRV-KLSDFG 164 Query: 203 SAKQLVRGEPN-VSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDS 261 Q+ + P S + + Y+ APE+I + Y + +D+WS G ++ E++ G+P + DS Sbjct: 165 FCAQISKDVPKRKSLVGTPYWMAPEVI-SRSLYATEVDIWSLGIMVIEMVDGEPPYFSDS 223 Query: 262 GVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLL 321 V + + + P + P R+L Sbjct: 224 PVQAMKRL--------------------------RDSPPPKLKNSHKVSPVLRDFLERML 257 Query: 322 EYTPTARLTPLEACAHSFFDELRDPNVKLP 351 P R T E H F + P +P Sbjct: 258 VRDPQERATAQELLDHPFLLQTGLPECLVP 287 >3TXO-A nrPDB Length = 353 Score = 238 bits (606), Expect = 5e-63, Method: Composition-based stats. Identities = 76/352 (21%), Positives = 135/352 (38%), Gaps = 63/352 (17%) Query: 48 PDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNR-------ELQI 100 +R ++ +V+G GSFG V A++ ++G+L A+K + +D ++ E +I Sbjct: 17 SNRLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRI 76 Query: 101 MRKL-DHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVK 159 + +H + +L F + L V+++V + + + + Sbjct: 77 LSLARNHPFLTQLFCCFQTPDR------LFFVMEFVNGG---DLMFHIQKSRRFDEARAR 127 Query: 160 LYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ-LVRGEPNVSYIC 218 Y ++ +L ++H GI +RD+K N+LLD + KL DFG K+ + G ++ Sbjct: 128 FYAAEIISALMFLHDKGIIYRDLKLDNVLLDHEGH-CKLADFGMCKEGICNGVTTATFCG 186 Query: 219 SRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTR 278 + Y APE I Y ++D W+ G +L E+L G F ++ D I+ Sbjct: 187 TPDYIAPE-ILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILN------- 238 Query: 279 EQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLE----- 333 E +P W +A + + PT RL L Sbjct: 239 ----------DEVVYP-----TWLH-------EDATGILKSFMTKNPTMRLGSLTQGGEH 276 Query: 334 -ACAHSFFDELRDPNVK--------LPNGRDTPALFNFTTQELSSNPPLATI 376 H FF E+ + P + + NF + P L I Sbjct: 277 AILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLTPI 328 >1FOT-A nrPDB Length = 318 Score = 237 bits (604), Expect = 7e-63, Method: Composition-based stats. Identities = 71/306 (23%), Positives = 124/306 (40%), Gaps = 54/306 (17%) Query: 50 RPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQD-------KRFKNRELQIMR 102 + + + +G GSFG V+ + +G A+K + ++ N E ++ Sbjct: 2 KYSLQDFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLS 61 Query: 103 KLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYM 162 + H I+R+ F +D + +++DY+ R Q P K Y Sbjct: 62 IVTHPFIIRMWGTF------QDAQQIFMIMDYIEGGELFSLL---RKSQRFPNPVAKFYA 112 Query: 163 YQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYY 222 ++ +L Y+HS I +RD+KP+N+LLD + +K+ DFG AK + + + + Y Sbjct: 113 AEVCLALEYLHSKDIIYRDLKPENILLDKNGH-IKITDFGFAKYVP--DVTYTLCGTPDY 169 Query: 223 RAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIR 282 APE++ Y SID WS G ++ E+L G F + + +I+ Sbjct: 170 IAPEVV-STKPYNKSIDWWSFGILIYEMLAGYTPFYDSNTMKTYEKILNA---------- 218 Query: 283 EMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARL-----TPLEACAH 337 E +FP P + L SRL+ + RL + H Sbjct: 219 -------ELRFP------------PFFNEDVKDLLSRLITRDLSQRLGNLQNGTEDVKNH 259 Query: 338 SFFDEL 343 +F E+ Sbjct: 260 PWFKEV 265 >6C9D-A nrPDB Length = 459 Score = 237 bits (604), Expect = 8e-63, Method: Composition-based stats. Identities = 72/318 (22%), Positives = 122/318 (38%), Gaps = 47/318 (14%) Query: 49 DRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ------DKRFKNRELQIMR 102 ++P +Y K IG G+F V A+ +G VA+K + + + RE++IM+ Sbjct: 16 EQPHIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMK 75 Query: 103 KLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPET-VYRVARHYSRAKQTLPVIYVKLY 161 L+H NIV+L + E L LV++Y V+ + R K + Sbjct: 76 ILNHPNIVKLFEVI------ETEKTLYLVMEYASGGEVFDYLVAHGRMK----EKEARAK 125 Query: 162 MYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY 221 Q+ ++ Y H I HRD+K +NLLLD D +K+ DFG + + G + S Sbjct: 126 FRQIVSAVQYCHQKYIVHRDLKAENLLLDGDMN-IKIADFGFSNEFTVGNKLDEFCGSPP 184 Query: 222 YRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQI 281 Y APEL G +DVWS G +L L+ G F G + + +++ Sbjct: 185 YAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLR---------- 234 Query: 282 REMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFD 341 +++ P + + + P R + + + + Sbjct: 235 -------GKYRIPFYMSTDCENLLKKLLVLN------------PIKRGSLEQIMKDRWMN 275 Query: 342 ELRDPNVKLPNGRDTPAL 359 + P P Sbjct: 276 VGHEEEELKPYTEPDPDF 293 >3PFQ-A nrPDB Length = 674 Score = 237 bits (604), Expect = 9e-63, Method: Composition-based stats. Identities = 78/361 (21%), Positives = 145/361 (40%), Gaps = 71/361 (19%) Query: 49 DRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQ---IMRKL- 104 DR + + V+G GSFG V ++ + EL A+K + +D ++ +++ + +++ Sbjct: 336 DRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVL 395 Query: 105 ----DHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKL 160 + +L F + L V++YV ++ + + Sbjct: 396 ALPGKPPFLTQLHSCFQTMDR------LYFVMEYVNGG---DLMYHIQQVGRFKEPHAVF 446 Query: 161 YMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ-LVRGEPNVSYICS 219 Y ++ L ++ S GI +RD+K N++LD + +K+ DFG K+ + G ++ + Sbjct: 447 YAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGH-IKIADFGMCKENIWDGVTTKTFCGT 505 Query: 220 RYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTRE 279 Y APE+I Y S+D W+ G +L E+L GQ F G+ + I++ Sbjct: 506 PDYIAPEII-AYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIME-------- 556 Query: 280 QIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTP-----LEA 334 +P+ EA+A+C L+ P RL + Sbjct: 557 ---------HNVAYPKSM------------SKEAVAICKGLMTKHPGKRLGCGPEGERDI 595 Query: 335 CAHSFF----------DELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARI 384 H+FF E++ P +GR+ F T+ +PP +L PP + Sbjct: 596 KEHAFFRYIDWEKLERKEIQPPYKPKASGRNAENFDRFFTR----HPP---VLTPPDQEV 648 Query: 385 Q 385 Sbjct: 649 I 649 >4D2V-A nrPDB Length = 356 Score = 236 bits (602), Expect = 1e-62, Method: Composition-based stats. Identities = 78/322 (24%), Positives = 135/322 (41%), Gaps = 46/322 (14%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ-----DKRFKNRELQIMRKLDHCNIV 110 Y + IG G F V A +GE+VAIK + + D E++ ++ L H +I Sbjct: 31 YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNLRHQHIC 90 Query: 111 RLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLA 170 +L + ++ + + +VL+Y P Y ++ L ++ Q+ ++A Sbjct: 91 QLYHVLETANK------IFMVLEYCPGGELF---DYIISQDRLSEEETRVVFRQIVSAVA 141 Query: 171 YIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLV--RGEPNVSYICSRYYRAPELI 228 Y+HS G HRD+KP+NLL D + LKL DFG + + + + Y APELI Sbjct: 142 YVHSQGYAHRDLKPENLLFD-EYHKLKLIDFGLCAKPKGNKDYHLQACCGALAYAAPELI 200 Query: 229 FGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNY 288 G + S DVWS G +L L+ G F D+ + +I++ Sbjct: 201 QGKSYLGSEADVWSMGILLYVLMCGFLPFDDDTAAALVAKIMR----------------- 243 Query: 289 TEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNV 348 ++ P+ P +I L ++L+ P R++ H + + + V Sbjct: 244 GKYDVPKW------------LSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPV 291 Query: 349 KLPNGRDTPALFNFTTQELSSN 370 + + L + ELS + Sbjct: 292 EWQSKNPFIHLDDDCVTELSVH 313 >4CQG-A nrPDB Length = 331 Score = 236 bits (601), Expect = 2e-62, Method: Composition-based stats. Identities = 79/322 (24%), Positives = 131/322 (40%), Gaps = 46/322 (14%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ-----DKRFKNRELQIMRKLDHCNIV 110 Y + IG G F V A +GE+VAIK + + D E+ ++ L H +I Sbjct: 11 YELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGSDLPRVKTEIDALKSLRHQHIC 70 Query: 111 RLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLA 170 +L + + + + +VL+Y P Y ++ L ++ Q+ ++A Sbjct: 71 QLYHVLETKNK------IFMVLEYCPGGELF---DYIISQDRLSEEETRVVFRQILSAVA 121 Query: 171 YIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLV--RGEPNVSYICSRYYRAPELI 228 Y+HS G HRD+KP+NLL D + LKL DFG + + S Y APELI Sbjct: 122 YVHSQGYAHRDLKPENLLFD-ENHKLKLIDFGLCAKPKGNKDYHLQECCGSLAYAAPELI 180 Query: 229 FGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNY 288 G + S DVWS G +L L+ G F D+ + +I++ Sbjct: 181 QGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMR----------------- 223 Query: 289 TEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNV 348 +++ P+ P +I L ++L+ P R++ H + + V Sbjct: 224 GKYEVPKW------------LSPSSILLLQQMLQVDPKKRISMRNLLNHPWVMQDYSCPV 271 Query: 349 KLPNGRDTPALFNFTTQELSSN 370 + + L ELS + Sbjct: 272 EWQSKTPLTHLDEDCVTELSVH 293 >6FD3-A nrPDB Length = 300 Score = 236 bits (601), Expect = 2e-62, Method: Composition-based stats. Identities = 74/319 (23%), Positives = 128/319 (40%), Gaps = 48/319 (15%) Query: 28 VSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKV 87 D++ + + + G + YT + IG G+ G VY A +G+ VAIK++ Sbjct: 1 SMTDEEILEKLRSIVSVGDPKKK-----YTRFEKIGQGASGTVYTALDIATGQEVAIKQM 55 Query: 88 LQDKRFKNR----ELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVA 143 ++ K E+ +MR+ + NIV + E L +V++Y+ Sbjct: 56 NLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDE------LWVVMEYLAGGSLTDV 109 Query: 144 RHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGS 203 + + + + ++L ++HS + HRDIK N+LL D +V KL DFG Sbjct: 110 V----TETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSV-KLTDFGF 164 Query: 204 AKQLVRGEPNVSY-ICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSG 262 Q+ + S + + Y+ APE++ Y +D+WS G + E++ G+P + ++ Sbjct: 165 CAQITPEQSKRSTMVGTPYWMAPEVVT-RKAYGPKVDIWSLGIMAIEMVEGEPPYLNENP 223 Query: 263 VDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLE 322 + L I GTP + NP R +R LE Sbjct: 224 LRALYLI-ATNGTPELQ-----NPE--------------------RLSAVFRDFLNRCLE 257 Query: 323 YTPTARLTPLEACAHSFFD 341 R + E H F Sbjct: 258 MDVDRRGSAKELLQHPFLK 276 >3UTO-A nrPDB Length = 573 Score = 236 bits (601), Expect = 2e-62, Method: Composition-based stats. Identities = 76/357 (21%), Positives = 132/357 (36%), Gaps = 46/357 (12%) Query: 44 PGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVL----QDKRFKNRELQ 99 P + Y + +G G+FGVV++ +G A K V+ DK +E+Q Sbjct: 147 PVEIKHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKETVRKEIQ 206 Query: 100 IMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVK 159 M L H +V L F E + ++ +++ + + + Sbjct: 207 TMSVLRHPTLVNLHDAFEDDNE------MVMIYEFMSGG--ELFEKVADEHNKMSEDEAV 258 Query: 160 LYMYQLFRSLAYIHSFGICHRDIKPQNLLL-DPDTAVLKLCDFGSAKQLVRGEPNVSYIC 218 YM Q+ + L ++H H D+KP+N++ + LKL DFG L + Sbjct: 259 EYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTTG 318 Query: 219 SRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTR 278 + + APE+ G D+WS G + LL G F G++ + L + Sbjct: 319 TAEFAAPEVAEG-KPVGYYTDMWSVGVLSYILLSGLSPFGGENDDETLRNV--------- 368 Query: 279 EQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHS 338 + + N + F I + +LL P R+T +A H Sbjct: 369 ---KSCDWNMDDSAFSGI-------------SEDGKDFIRKLLLADPNTRMTIHQALEHP 412 Query: 339 FFDELRDP--NVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASPPAN 393 + P + ++P+ R T + T+ + PL PP RI +S + Sbjct: 413 WLTPGNAPGRDSQIPSSRYTKIRDSIKTKYDAWPEPL-----PPLGRISNYSSLRKH 464 >3HDN-A nrPDB Length = 373 Score = 235 bits (600), Expect = 2e-62, Method: Composition-based stats. Identities = 85/397 (21%), Positives = 147/397 (37%), Gaps = 61/397 (15%) Query: 17 VQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLC 76 + QP M + + + P P + + KVIG GSFG V A+ Sbjct: 2 ISQPQEPELMNANPAPPPAPSQQINLGPSSNP-HAKPSDFHFLKVIGKGSFGKVLLARHK 60 Query: 77 DSGELVAIKKVLQDKRFKNRELQ--------IMRKLDHCNIVRLRYFFYSSGEKKDEVYL 128 A+K + + K +E + +++ + H +V L + F ++ + L Sbjct: 61 AEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADK------L 114 Query: 129 NLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLL 188 VLDY+ ++ + ++ + Y ++ +L Y+HS I +RD+KP+N+L Sbjct: 115 YFVLDYINGGELF---YHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENIL 171 Query: 189 LDPDTAVLKLCDFGSAKQ-LVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVL 247 LD ++ L DFG K+ + ++ + Y APE++ Y ++D W G VL Sbjct: 172 LDSQGHIV-LTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLH-KQPYDRTVDWWCLGAVL 229 Query: 248 AELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRP 307 E+L G P F + + I+ +P Sbjct: 230 YEMLYGLPPFYSRNTAEMYDNILNK-----------------------------PLQLKP 260 Query: 308 RTPPEAIALCSRLLEYTPTARLTPL----EACAHSFF-----DELRDPNVKLPNGRDT-- 356 A L LL+ T RL E +H FF D+L + + P + Sbjct: 261 NITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSG 320 Query: 357 PALFNFTTQELSSNPPLATILIPPHARIQAAASPPAN 393 P E + P I P + + A+ A Sbjct: 321 PNDLRHFDPEFTEEPVPNAIGKAPDSVLVTASVKEAA 357 >4XBR-A nrPDB Length = 366 Score = 235 bits (600), Expect = 2e-62, Method: Composition-based stats. Identities = 82/330 (24%), Positives = 137/330 (41%), Gaps = 49/330 (14%) Query: 27 KVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKK 86 +VS ++ + + VV PG R ++ IG GS G+V A + SG+LVA+KK Sbjct: 73 RVSHEQFRAALQLVV-DPGDP--RSYLDNFI---KIGEGSTGIVCIATVRSSGKLVAVKK 126 Query: 87 VLQDKRFKNR----ELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRV 142 + K+ + E+ IMR H N+V + + E L +V++++ Sbjct: 127 MDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDE------LWVVMEFLEGGALTD 180 Query: 143 ARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFG 202 ++R + + + ++L+ +H+ G+ HRDIK ++LL D V KL DFG Sbjct: 181 IVTHTR----MNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRV-KLSDFG 235 Query: 203 SAKQLVRGEPN-VSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDS 261 Q+ + P S + + Y+ APELI Y +D+WS G ++ E++ G+P + + Sbjct: 236 FCAQVSKEVPRRKSLVGTPYWMAPELI-SRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEP 294 Query: 262 GVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLL 321 + + I L P + P RLL Sbjct: 295 PLKAMKMIRDNL--------------------------PPRLKNLHKVSPSLKGFLDRLL 328 Query: 322 EYTPTARLTPLEACAHSFFDELRDPNVKLP 351 P R T E H F + P +P Sbjct: 329 VRDPAQRATAAELLKHPFLAKAGPPASIVP 358 >2I0E-A nrPDB Length = 353 Score = 235 bits (600), Expect = 2e-62, Method: Composition-based stats. Identities = 78/361 (21%), Positives = 144/361 (39%), Gaps = 71/361 (19%) Query: 49 DRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQ---IMRKL- 104 DR + + V+G GSFG V ++ + EL A+K + +D ++ +++ + +++ Sbjct: 15 DRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVL 74 Query: 105 ----DHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKL 160 + +L F + L V++YV ++ + + Sbjct: 75 ALPGKPPFLTQLHSCFQTMDR------LYFVMEYVNGG---DLMYHIQQVGRFKEPHAVF 125 Query: 161 YMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ-LVRGEPNVSYICS 219 Y ++ L ++ S GI +RD+K N++LD + +K+ DFG K+ + G ++ + Sbjct: 126 YAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGH-IKIADFGMCKENIWDGVTTKTFCGT 184 Query: 220 RYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTRE 279 Y APE+I Y S+D W+ G +L E+L GQ F G+ + I++ Sbjct: 185 PDYIAPEII-AYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIME-------- 235 Query: 280 QIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTP-----LEA 334 +P+ EA+A+C L+ P RL + Sbjct: 236 ---------HNVAYPKSM------------SKEAVAICKGLMTKHPGKRLGCGPEGERDI 274 Query: 335 CAHSFF----------DELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARI 384 H+FF E++ P GR+ F T+ +PP +L PP + Sbjct: 275 KEHAFFRYIDWEKLERKEIQPPYKPKACGRNAENFDRFFTR----HPP---VLTPPDQEV 327 Query: 385 Q 385 Sbjct: 328 I 328 >2Q0N-A nrPDB Length = 301 Score = 235 bits (600), Expect = 2e-62, Method: Composition-based stats. Identities = 82/330 (24%), Positives = 137/330 (41%), Gaps = 49/330 (14%) Query: 27 KVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKK 86 +VS ++ + + VV PG R ++ IG GS G+V A + SG+LVA+KK Sbjct: 8 RVSHEQFRAALQLVV-DPGDP--RSYLDNFI---KIGEGSTGIVCIATVRSSGKLVAVKK 61 Query: 87 VLQDKRFKNR----ELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRV 142 + K+ + E+ IMR H N+V + + E L +V++++ Sbjct: 62 MDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDE------LWVVMEFLEGGALTD 115 Query: 143 ARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFG 202 ++R + + + ++L+ +H+ G+ HRDIK ++LL D V KL DFG Sbjct: 116 IVTHTR----MNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRV-KLSDFG 170 Query: 203 SAKQLVRGEPN-VSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDS 261 Q+ + P S + + Y+ APELI Y +D+WS G ++ E++ G+P + + Sbjct: 171 FCAQVSKEVPRRKSLVGTPYWMAPELI-SRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEP 229 Query: 262 GVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLL 321 + + I L P + P RLL Sbjct: 230 PLKAMKMIRDNL--------------------------PPRLKNLHKVSPSLKGFLDRLL 263 Query: 322 EYTPTARLTPLEACAHSFFDELRDPNVKLP 351 P R T E H F + P +P Sbjct: 264 VRDPAQRATAAELLKHPFLAKAGPPASIVP 293 >6FYV-A nrPDB Length = 337 Score = 235 bits (599), Expect = 3e-62, Method: Composition-based stats. Identities = 79/333 (23%), Positives = 143/333 (42%), Gaps = 54/333 (16%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCD-SGELVAIKKVLQDKRFKN---RELQIMRKLDH--CN 108 Y +G G+FG V + G VA+K V R++ E+Q++ L+ N Sbjct: 15 RYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPN 74 Query: 109 ----IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQ 164 V++ +F G ++ +V + + + Y + S + +++ YQ Sbjct: 75 SVFRCVQMLEWFDHHG------HVCIVFELLGLSTYDFIKENSFL--PFQIDHIRQMAYQ 126 Query: 165 LFRSLAYIHSFGICHRDIKPQNLLL------------------DPDTAVLKLCDFGSAKQ 206 + +S+ ++H + H D+KP+N+L +K+ DFGSA Sbjct: 127 ICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSAT- 185 Query: 207 LVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQL 266 E + + + +R+YRAPE+I A ++ DVWS GC+L E LG +F + L Sbjct: 186 -YDDEHHSTLVSTRHYRAPEVIL-ALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHL 243 Query: 267 VEIIKVLGTPTREQIRE-------------MNPNYTEFKFPQIKAHPWTKVF--RPRTPP 311 + ++LG + I++ + + + ++ + + P + Sbjct: 244 AMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHE 303 Query: 312 EAIALCSRLLEYTPTARLTPLEACAHSFFDELR 344 + L R+LEY PT R+T EA H FFD L+ Sbjct: 304 KLFDLVRRMLEYDPTQRITLDEALQHPFFDLLK 336 >4JDH-A nrPDB Length = 346 Score = 235 bits (599), Expect = 3e-62, Method: Composition-based stats. Identities = 85/354 (24%), Positives = 142/354 (40%), Gaps = 49/354 (13%) Query: 3 GRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVI 62 R R + P + +VS ++ + + VV PG R ++ I Sbjct: 29 ARARQENGMPEKPPGPRSPQREPQRVSHEQFRAALQLVV-DPGDP--RSYLDNFI---KI 82 Query: 63 GNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNR----ELQIMRKLDHCNIVRLRYFFYS 118 G GS G+V A + SG+LVA+KK+ K+ + E+ IMR H N+V + + Sbjct: 83 GEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLV 142 Query: 119 SGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGIC 178 E L +V++++ ++R + + + ++L+ +H+ G+ Sbjct: 143 GDE------LWVVMEFLEGGALTDIVTHTR----MNEEQIAAVCLAVLQALSVLHAQGVI 192 Query: 179 HRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPN-VSYICSRYYRAPELIFGATDYTSS 237 HRDIK ++LL D V KL DFG Q+ + P S + + Y+ APELI Y Sbjct: 193 HRDIKSDSILLTHDGRV-KLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELI-SRLPYGPE 250 Query: 238 IDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIK 297 +D+WS G ++ E++ G+P + + + + I L Sbjct: 251 VDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNL------------------------ 286 Query: 298 AHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLP 351 P + P RLL P R T E H F + P +P Sbjct: 287 --PPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVP 338 >2PVN-A nrPDB Length = 352 Score = 234 bits (597), Expect = 5e-62, Method: Composition-based stats. Identities = 93/309 (30%), Positives = 145/309 (46%), Gaps = 31/309 (10%) Query: 52 QEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIK------KVLQDKRFKNRELQIMRKLD 105 ++ Y + +G G + V++ ++ E K K ++ K+ K + Sbjct: 50 EQDDYEVVRKVGRGKYSEVFEGINVNNNE----KCIIKILKPVKKKKIKREIKILQNLCG 105 Query: 106 HCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQL 165 NIV+L K L+ +YV T ++V TL ++ Y+Y+L Sbjct: 106 GPNIVKLLDIVRDQHSKTPS----LIFEYVNNTDFKVL------YPTLTDYDIRYYIYEL 155 Query: 166 FRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAP 225 ++L Y HS GI HRD+KP N+++D + L+L D+G A+ G+ + SRY++ P Sbjct: 156 LKALDYCHSQGIMHRDVKPHNVMIDHELRKLRLIDWGLAEFYHPGKEYNVRVASRYFKGP 215 Query: 226 ELIFGATDYTSSIDVWSAGCVLAELLLG-QPIFPGDSGVDQLVEIIKVLGTPT-----RE 279 EL+ DY S+D+WS GC+ A ++ +P F G DQLV+I KVLGT + Sbjct: 216 ELLVDLQDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKIAKVLGTDGLNAYLNK 275 Query: 280 QIREMNPNYTEFKFPQIKAHPWTKVFRPRT----PPEAIALCSRLLEYTPTARLTPLEAC 335 E++P E + PW K PEAI +LL Y RLT LEA Sbjct: 276 YRIELDPQL-EALVGRHSRKPWLKFMNADNQHLVSPEAIDFLDKLLRYDHQERLTALEAM 334 Query: 336 AHSFFDELR 344 H +F ++R Sbjct: 335 THPYFQQVR 343 >4FIE-A nrPDB Length = 423 Score = 234 bits (597), Expect = 5e-62, Method: Composition-based stats. Identities = 87/359 (24%), Positives = 145/359 (40%), Gaps = 53/359 (14%) Query: 2 SGRPRTTSFAESCKPVQQPSAFGSMK----VSRDKDGSKVTTVVATPGQGPDRPQEVSYT 57 S P + E+ P + P + VS ++ + + VV PG R ++ Sbjct: 101 SPPPPARARQENGMPEKPPGPRSPQREPQRVSHEQFRAALQLVV-DPGDP--RSYLDNFI 157 Query: 58 DTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNR----ELQIMRKLDHCNIVRLR 113 IG GS G+V A + SG+LVA+KK+ K+ + E+ IMR H N+V + Sbjct: 158 ---KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMY 214 Query: 114 YFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIH 173 + E L +V++++ ++R + + + ++L+ +H Sbjct: 215 NSYLVGDE------LWVVMEFLEGGALTDIVTHTR----MNEEQIAAVCLAVLQALSVLH 264 Query: 174 SFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPN-VSYICSRYYRAPELIFGAT 232 + G+ HRDIK ++LL D V KL DFG Q+ + P S + + Y+ APELI Sbjct: 265 AQGVIHRDIKSDSILLTHDGRV-KLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELI-SRL 322 Query: 233 DYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFK 292 Y +D+WS G ++ E++ G+P + + + + I L Sbjct: 323 PYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNL------------------- 363 Query: 293 FPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLP 351 P + P RLL P R T E H F + P +P Sbjct: 364 -------PPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVP 415 >5X8I-B nrPDB Length = 346 Score = 234 bits (597), Expect = 5e-62, Method: Composition-based stats. Identities = 79/338 (23%), Positives = 142/338 (42%), Gaps = 54/338 (15%) Query: 55 SYTDTKVIGNGSFGVVYQAK-LCDSGELVAIKKVLQDKRFKN---RELQIMRKLD--HCN 108 Y +G G+FG V + G VA+K V R+ E+Q++ L+ N Sbjct: 14 RYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPN 73 Query: 109 ----IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQ 164 V++ +F G ++ +V + + + Y + L +++ YQ Sbjct: 74 STFRCVQMLEWFEHHG------HICIVFELLGLSTYDFIKENGFLPFRLD--HIRKMAYQ 125 Query: 165 LFRSLAYIHSFGICHRDIKPQNLLLDPD------------------TAVLKLCDFGSAKQ 206 + +S+ ++HS + H D+KP+N+L +K+ DFGSA Sbjct: 126 ICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSAT- 184 Query: 207 LVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQL 266 E + + + +R+YRAPE+I A ++ DVWS GC+L E LG +FP + L Sbjct: 185 -YDDEHHSTLVSTRHYRAPEVIL-ALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHL 242 Query: 267 VEIIKVLGTPTREQIRE-------------MNPNYTEFKFPQIKAHPWTKVFRPRT--PP 311 + ++LG + I++ + + + ++ P + + Sbjct: 243 AMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQDVEHE 302 Query: 312 EAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVK 349 L ++LEY P R+T EA H FFD L+ ++ Sbjct: 303 RLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSILE 340 >5JZN-A nrPDB Length = 280 Score = 234 bits (596), Expect = 7e-62, Method: Composition-based stats. Identities = 81/312 (25%), Positives = 123/312 (39%), Gaps = 44/312 (14%) Query: 39 TVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDK-----RF 93 V Q P E Y + IG+G+F VV + + A+K + + K Sbjct: 5 EVSEEGFQIPATITE-RYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHM 63 Query: 94 KNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTL 153 E+ I+R++ H NIV L E L LV++ V A + Sbjct: 64 IQNEVSILRRVKHPNIVLLIEEMDVPTE------LYLVMELVKGGDLFDA---ITSTNKY 114 Query: 154 PVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLL---DPDTAVLKLCDFGSAKQLVRG 210 +Y L ++ Y+HS I HRDIKP+NLL+ + LKL DFG A + Sbjct: 115 TERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIV--D 172 Query: 211 EPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEII 270 P + + Y APE+I T Y +D+W+AG + LL G P F G SG DQ V Sbjct: 173 GPLYTVCGTPTYVAPEII-AETGYGLKVDIWAAGVITYILLCGFPPFRG-SGDDQEVLFD 230 Query: 271 KVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLT 330 ++L + FP + A L + +L R + Sbjct: 231 QIL--------------MGQVDFPSP--------YWDNVSDSAKELITMMLLVDVDQRFS 268 Query: 331 PLEACAHSFFDE 342 ++ H + ++ Sbjct: 269 AVQVLEHPWVND 280 >1KOA-A nrPDB Length = 491 Score = 234 bits (596), Expect = 7e-62, Method: Composition-based stats. Identities = 76/357 (21%), Positives = 132/357 (36%), Gaps = 46/357 (12%) Query: 44 PGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVL----QDKRFKNRELQ 99 P + Y + +G G+FGVV++ +G A K V+ DK +E+Q Sbjct: 41 PVEIKHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKETVRKEIQ 100 Query: 100 IMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVK 159 M L H +V L F E + ++ +++ + + + Sbjct: 101 TMSVLRHPTLVNLHDAFEDDNE------MVMIYEFMSGG--ELFEKVADEHNKMSEDEAV 152 Query: 160 LYMYQLFRSLAYIHSFGICHRDIKPQNLLL-DPDTAVLKLCDFGSAKQLVRGEPNVSYIC 218 YM Q+ + L ++H H D+KP+N++ + LKL DFG L + Sbjct: 153 EYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTTG 212 Query: 219 SRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTR 278 + + APE+ G D+WS G + LL G F G++ + L + Sbjct: 213 TAEFAAPEVAEG-KPVGYYTDMWSVGVLSYILLSGLSPFGGENDDETLRNV--------- 262 Query: 279 EQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHS 338 + + N + F I + +LL P R+T +A H Sbjct: 263 ---KSCDWNMDDSAFSGI-------------SEDGKDFIRKLLLADPNTRMTIHQALEHP 306 Query: 339 FFDELRDP--NVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASPPAN 393 + P + ++P+ R T + T+ + PL PP RI +S + Sbjct: 307 WLTPGNAPGRDSQIPSSRYTKIRDSIKTKYDAWPEPL-----PPLGRISNYSSLRKH 358 >1NY3-A nrPDB Length = 400 Score = 234 bits (596), Expect = 8e-62, Method: Composition-based stats. Identities = 83/306 (27%), Positives = 132/306 (43%), Gaps = 31/306 (10%) Query: 54 VSYTDT-KVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKL-DHCNIVR 111 Y T +V+G G G V Q + E A+K +LQD RE+++ + +IVR Sbjct: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALK-MLQDCPKARREVELHWRASQCPHIVR 119 Query: 112 LRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAY 171 + + + + L +V++ + +R R Q M + ++ Y Sbjct: 120 IVDVYENLYAGRK--CLLIVMECLDGGEL-FSRIQDRGDQAFTEREASEIMKSIGEAIQY 176 Query: 172 IHSFGICHRDIKPQNLLLDPD--TAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIF 229 +HS I HRD+KP+NLL A+LKL DFG AK+ + + YY APE++ Sbjct: 177 LHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVL- 235 Query: 230 GATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYT 289 G Y S D+WS G ++ LL G P F + G+ + + +IR Sbjct: 236 GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGL--------AISPGMKTRIRM-----G 282 Query: 290 EFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF-DELRDPNV 348 +++FP + W++V E L LL+ PT R+T E H + + P Sbjct: 283 QYEFPNPE---WSEV-----SEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQT 334 Query: 349 KLPNGR 354 L R Sbjct: 335 PLHTSR 340 >2WO6-A nrPDB Length = 382 Score = 234 bits (596), Expect = 8e-62, Method: Composition-based stats. Identities = 103/384 (26%), Positives = 164/384 (42%), Gaps = 66/384 (17%) Query: 12 ESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVY 71 E+ S KV D + G+ Y +IG GSFG V Sbjct: 16 ENLYFQSMSSHKKERKVYNDGYDDDNYDYIVKNGE----KWMDRYEIDSLIGKGSFGQVV 71 Query: 72 QAKLCDSGELVAIKKVLQDKRFKNR---ELQIMRKLD-HC-----NIVRLRYFFYSSGEK 122 +A E VAIK + K F N+ E++++ ++ H IV L+ F Sbjct: 72 KAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHF------ 125 Query: 123 KDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIH--SFGICHR 180 +L LV + + +Y + R+ + +L + + + Q+ +L ++ I H Sbjct: 126 MFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNL--TRKFAQQMCTALLFLATPELSIIHC 183 Query: 181 DIKPQNLLL-DPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSID 239 D+KP+N+LL +P + +K+ DFGS+ QL G+ YI SR+YR+PE++ G Y +ID Sbjct: 184 DLKPENILLCNPKRSAIKIVDFGSSCQL--GQRIYQYIQSRFYRSPEVLLG-MPYDLAID 240 Query: 240 VWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH 299 +WS GC+L E+ G+P+F G + VDQ+ +I++VLG P I + P +F F ++ Sbjct: 241 MWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAH-ILDQAPKARKF-FEKLPDG 298 Query: 300 PWTKVFRPRTPPE-------------------------------------AIALCSRLLE 322 W E L R+L+ Sbjct: 299 TWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLD 358 Query: 323 YTPTARLTPLEACAHSFFDELRDP 346 Y P R+ P A HSFF + D Sbjct: 359 YDPKTRIQPYYALQHSFFKKTADE 382 >2OZA-A nrPDB Length = 356 Score = 233 bits (594), Expect = 1e-61, Method: Composition-based stats. Identities = 83/306 (27%), Positives = 132/306 (43%), Gaps = 31/306 (10%) Query: 54 VSYTDT-KVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKL-DHCNIVR 111 Y T +V+G G G V Q + E A+K +LQD RE+++ + +IVR Sbjct: 17 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALK-MLQDCPKARREVELHWRASQCPHIVR 75 Query: 112 LRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAY 171 + + + + L +V++ + +R R Q M + ++ Y Sbjct: 76 IVDVYENLYAGRK--CLLIVMECLDGGEL-FSRIQDRGDQAFTEREASEIMKSIGEAIQY 132 Query: 172 IHSFGICHRDIKPQNLLLDPD--TAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIF 229 +HS I HRD+KP+NLL A+LKL DFG AK+ + + YY APE++ Sbjct: 133 LHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVL- 191 Query: 230 GATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYT 289 G Y S D+WS G ++ LL G P F + G+ + + +IR Sbjct: 192 GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGL--------AISPGMKTRIRM-----G 238 Query: 290 EFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF-DELRDPNV 348 +++FP + W++V E L LL+ PT R+T E H + + P Sbjct: 239 QYEFPNPE---WSEV-----SEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQT 290 Query: 349 KLPNGR 354 L R Sbjct: 291 PLHTSR 296 >4D28-A nrPDB Length = 446 Score = 233 bits (594), Expect = 1e-61, Method: Composition-based stats. Identities = 86/299 (28%), Positives = 125/299 (41%), Gaps = 47/299 (15%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNR-------ELQIMRKLDHCN 108 Y + IG G+F V A+ D+G+ VAIK + + KNR E+ IM+ + H N Sbjct: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRS 168 IVRL K ++Y+ L E R+ K L + Y QL + Sbjct: 71 IVRLYEVL----ASKSKIYIVLEFVTGGELFDRIVH-----KGRLKEDESRKYFQQLVDA 121 Query: 169 LAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRG-EPNVSYICSRYYRAPEL 227 +A+ HS G+ HRD+KP+NLLLD + LK+ DFG + G E + Y APE+ Sbjct: 122 VAHCHSKGVYHRDLKPENLLLDTNGN-LKVSDFGLSALPQEGVELLNDTCGTPNYVAPEV 180 Query: 228 IFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPN 287 + G S+ D+WS G +L +L G F ++ + L I N Sbjct: 181 LSGQGYDGSAADIWSCGVILFVILAGYLPF-SETDLPGLYRKI----------------N 223 Query: 288 YTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDP 346 EF P PW E L R+L+ P R+ +F + P Sbjct: 224 AAEFDCP-----PW-------FSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRKNYVP 270 >6HMD-A nrPDB Length = 365 Score = 233 bits (594), Expect = 1e-61, Method: Composition-based stats. Identities = 94/339 (27%), Positives = 153/339 (45%), Gaps = 27/339 (7%) Query: 16 PVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKL 75 P+ P+A +V + + + P + Y + +G G + V++A Sbjct: 15 PMPGPAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAIN 74 Query: 76 CDSGELVAIKKVLQDKRFKNRE----LQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLV 131 + E V +K + K+ K + L+ +R NI++L K LV Sbjct: 75 ITNNERVVVKILKPVKKKKIKREVKILENLRG--GTNIIKLIDTVKDPVSKTPA----LV 128 Query: 132 LDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDP 191 +Y+ T ++ Q L ++ YMY+L ++L Y HS GI HRD+KP N+++D Sbjct: 129 FEYINNTDFKQL------YQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDH 182 Query: 192 DTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELL 251 L+L D+G A+ + + SRY++ PEL+ Y S+D+WS GC+LA ++ Sbjct: 183 QQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMI 242 Query: 252 LGQ-PIFPGDSGVDQLVEIIKVLGTPT-----REQIREMNPNYTEFKFPQIKAHPWTKVF 305 + P F G DQLV I KVLGT ++ +++P++ + Q W Sbjct: 243 FRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDI-LGQHSRKRWENFI 301 Query: 306 RPRT----PPEAIALCSRLLEYTPTARLTPLEACAHSFF 340 PEA+ L +LL Y RLT EA H +F Sbjct: 302 HSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 340 >3KA0-A nrPDB Length = 320 Score = 233 bits (594), Expect = 1e-61, Method: Composition-based stats. Identities = 83/306 (27%), Positives = 131/306 (42%), Gaps = 31/306 (10%) Query: 54 VSYTDT-KVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKL-DHCNIVR 111 Y T +V+G G G V Q + E A+K +LQD RE+++ + +IVR Sbjct: 15 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALK-MLQDCPKARREVELHWRASQCPHIVR 73 Query: 112 LRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAY 171 + + + + L +V++ + +R R Q M + ++ Y Sbjct: 74 IVDVYENLYAGRK--CLLIVMECLDGGEL-FSRIQDRGDQAFTEREASEIMKSIGEAIQY 130 Query: 172 IHSFGICHRDIKPQNLLLDPD--TAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIF 229 +HS I HRD+KP+NLL A+LKL DFG AK+ + YY APE++ Sbjct: 131 LHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTEPCYTPYYVAPEVL- 189 Query: 230 GATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYT 289 G Y S D+WS G ++ LL G P F + G+ + + +IR Sbjct: 190 GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGL--------AISPGMKTRIRM-----G 236 Query: 290 EFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF-DELRDPNV 348 +++FP + W++V E L LL+ PT R+T E H + + P Sbjct: 237 QYEFPNPE---WSEV-----SEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQT 288 Query: 349 KLPNGR 354 L R Sbjct: 289 PLHTSR 294 >1KOB-A nrPDB Length = 387 Score = 232 bits (593), Expect = 1e-61, Method: Composition-based stats. Identities = 67/293 (22%), Positives = 116/293 (39%), Gaps = 39/293 (13%) Query: 54 VSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVL----QDKRFKNRELQIMRKLDHCNI 109 Y + +G+G+FGVV++ +G + K + DK E+ IM +L H + Sbjct: 51 DYYDILEELGSGAFGVVHRCVEKATGRVFVAKFINTPYPLDKYTVKNEISIMNQLHHPKL 110 Query: 110 VRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 169 + L F E + L+L+++ + + + V YM Q L Sbjct: 111 INLHDAFEDKYE------MVLILEFLSGG--ELFDRIAAEDYKMSEAEVINYMRQACEGL 162 Query: 170 AYIHSFGICHRDIKPQNLLLDPDTAV-LKLCDFGSAKQLVRGEPNVSYICSRYYRAPELI 228 ++H I H DIKP+N++ + A +K+ DFG A +L E + + APE++ Sbjct: 163 KHMHEHSIVHLDIKPENIMCETKKASSVKIIDFGLATKLNPDEIVKVTTATAEFAAPEIV 222 Query: 229 FGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNY 288 D+W+ G + LL G F G+ ++ L + ++ + + Sbjct: 223 -DREPVGFYTDMWAIGVLGYVLLSGLSPFAGEDDLETL------------QNVKRCDWEF 269 Query: 289 TEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFD 341 E F + PEA LL+ P RLT +A H + Sbjct: 270 DEDAFSSV-------------SPEAKDFIKNLLQKEPRKRLTVHDALEHPWLK 309 >4B6L-A nrPDB Length = 281 Score = 232 bits (593), Expect = 2e-61, Method: Composition-based stats. Identities = 78/307 (25%), Positives = 123/307 (40%), Gaps = 48/307 (15%) Query: 49 DRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDK-------RFKNRELQIM 101 D +Y +++G G F Y+A ++G A+K + Q + E+++ Sbjct: 4 DPRSGRTYLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELH 63 Query: 102 RKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLY 161 R L H +IVR F E D +Y+ L L + H +A+ TL V+ Y Sbjct: 64 RDLQHRHIVR----FSHHFEDADNIYIFLEL-----CSRKSLAHIWKARHTLLEPEVRYY 114 Query: 162 MYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEP-NVSYICSR 220 + Q+ L Y+H GI HRD+K N + + LK+ DFG A +L E + + Sbjct: 115 LRQILSGLKYLHQRGILHRDLKLGNFFITENME-LKVGDFGLAARLEPPEQRKKTICGTP 173 Query: 221 YYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQ 280 Y APE++ + DVWS GCV+ LL G P F + I +V Sbjct: 174 NYVAPEVLL-RQGHGPEADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQV-------- 224 Query: 281 IREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF 340 + P + P A L + +L +P R + + H FF Sbjct: 225 ---------HYTLPASLSLP------------ARQLLAAILRASPRDRPSIDQILRHDFF 263 Query: 341 DELRDPN 347 + P+ Sbjct: 264 TKGYTPD 270 >5XVU-A nrPDB Length = 332 Score = 232 bits (591), Expect = 3e-61, Method: Composition-based stats. Identities = 84/305 (27%), Positives = 141/305 (46%), Gaps = 23/305 (7%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQI-MRKLDH-CNIVRL 112 Y K IG G + V+ + AIK + K+ K + ++ L+ NI++L Sbjct: 32 RYEIMKKIGRGKYSEVFNGYDTECNRPCAIKVLKPVKKKKIKREIKILQNLNGGPNIIKL 91 Query: 113 RYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYI 172 K L+ +Y+ ++ ++ Y+YQ+ ++L Y Sbjct: 92 LDIVKDPVTKTPS----LIFEYINNIDFKTL------YPKFTDKDIRYYIYQILKALDYC 141 Query: 173 HSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGAT 232 HS GI HRD+KP N+++D + ++L +G A+ G+ + SRYY+ PEL+ Sbjct: 142 HSQGIMHRDVKPHNIMIDHENRQIRLISWGLAEFYHPGQEYNVRVASRYYKGPELLIDLQ 201 Query: 233 DYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPT-----REQIREMNP 286 Y S+D+WS GC+LA ++ +P F G DQLV+I KVLGT ++ ++ P Sbjct: 202 LYDYSLDIWSLGCMLAGMIFKKEPFFCGHDNYDQLVKIAKVLGTEDLHAYLKKYNIKLKP 261 Query: 287 NYTEFKFPQIKAHPWTKVFRPRT----PPEAIALCSRLLEYTPTARLTPLEACAHSFFDE 342 +Y + + PW+ E I L ++L Y R+ P EA H +F E Sbjct: 262 HYLNI-LGEYERKPWSHFLTQSNIDIAKDEVIDLIDKMLIYDHAKRIAPKEAMEHPYFRE 320 Query: 343 LRDPN 347 +R+ + Sbjct: 321 VREES 325 >6EII-A nrPDB Length = 352 Score = 231 bits (590), Expect = 3e-61, Method: Composition-based stats. Identities = 90/328 (27%), Positives = 150/328 (45%), Gaps = 27/328 (8%) Query: 27 KVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKK 86 +V D + + + + + Y + +G G + V++A + E V +K Sbjct: 33 RVYTDVNTHRPSEYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKI 92 Query: 87 VLQDKRFKNRE----LQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRV 142 + K+ K + L+ +R NI+ L + LV ++V T ++ Sbjct: 93 LKPVKKKKIKREIKILENLRG--GPNIITLADIVKDPVSRTPA----LVFEHVNNTDFKQ 146 Query: 143 ARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFG 202 QTL ++ YMY++ ++L Y HS GI HRD+KP N+++D + L+L D+G Sbjct: 147 L------YQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWG 200 Query: 203 SAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQ-PIFPGDS 261 A+ G+ + SRY++ PEL+ Y S+D+WS GC+LA ++ + P F G Sbjct: 201 LAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHD 260 Query: 262 GVDQLVEIIKVLGTPT-----REQIREMNPNYTEFKFPQIKAHPWTKVFRPRT----PPE 312 DQLV I KVLGT + E++P + + + W + PE Sbjct: 261 NYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDI-LGRHSRKRWERFVHSENQHLVSPE 319 Query: 313 AIALCSRLLEYTPTARLTPLEACAHSFF 340 A+ +LL Y +RLT EA H +F Sbjct: 320 ALDFLDKLLRYDHQSRLTAREAMEHPYF 347 >4I6B-A nrPDB Length = 308 Score = 230 bits (587), Expect = 7e-61, Method: Composition-based stats. Identities = 70/322 (21%), Positives = 135/322 (41%), Gaps = 54/322 (16%) Query: 34 GSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRF 93 G +++ ++ P G Y+ K +G G F Y+ + ++ A K + + Sbjct: 14 GPEISRIIVDPTTGK------RYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVS 67 Query: 94 K-------NRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHY 146 K ++E+++ R L H ++V+ ++F +D+ + ++L+Y R H Sbjct: 68 KPHQREKIDKEIELHRILHHKHVVQFYHYF------EDKENIYILLEYCS---RRSMAHI 118 Query: 147 SRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ 206 +A++ L V+ Y+ Q+ L Y+H I HRD+K N ++ ++ LK+ DFG A + Sbjct: 119 LKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFIN-ESMELKVGDFGLAAR 177 Query: 207 LVRGEP-NVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQ 265 L E + + Y +PE++ + + D+W+ GCV+ +LLG+P F + + Sbjct: 178 LEPLEHRRRTICGTPNYLSPEVL-NKQGHGAESDIWALGCVMYTMLLGRPPFETTNLKET 236 Query: 266 LVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTP 325 I + + P P A L + +L P Sbjct: 237 YRSIREA-----------------RYTMPSSLLAP------------AKHLIASMLSKNP 267 Query: 326 TARLTPLEACAHSFFDELRDPN 347 R + + H FF + P+ Sbjct: 268 EDRPSLDDIIRHDFFTQGFTPD 289 >4CRL-A nrPDB Length = 406 Score = 230 bits (587), Expect = 8e-61, Method: Composition-based stats. Identities = 88/338 (26%), Positives = 154/338 (45%), Gaps = 39/338 (11%) Query: 54 VSYTDTKVIGNGSFGVVYQAKLCDSGEL--VAIKKVLQD--KRFKNRELQIMRKLDHCNI 109 Y KV G G++G VY+AK D + A+K++ RE+ ++R+L H N+ Sbjct: 23 FEYEGCKV-GRGTYGHVYKAKRKDGKDDKDYALKQIEGTGISMSACREIALLRELKHPNV 81 Query: 110 VRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHY-----SRAKQTLPVIYVKLYMYQ 164 + L+ F S ++K + L+ DY ++ + + + ++ LP VK +YQ Sbjct: 82 ISLQKVFLSHADRK----VWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQ 137 Query: 165 LFRSLAYIHSFGICHRDIKPQNLLL---DPDTAVLKLCDFGSAKQLVRGEPNVS----YI 217 + + Y+H+ + HRD+KP N+L+ P+ +K+ D G A+ ++ + Sbjct: 138 ILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVV 197 Query: 218 CSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSG---------VDQLVE 268 + +YRAPEL+ GA YT +ID+W+ GC+ AELL +PIF DQL Sbjct: 198 VTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDR 257 Query: 269 IIKVLGTPTREQIREMN---------PNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSR 319 I V+G P + ++ ++ + + + + + +A L + Sbjct: 258 IFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQK 317 Query: 320 LLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTP 357 LL P R+T +A +F E P + G P Sbjct: 318 LLTMDPIKRITSEQAMQDPYFLEDPLPTSDVFAGCQIP 355 >6ED6-A nrPDB Length = 415 Score = 230 bits (587), Expect = 8e-61, Method: Composition-based stats. Identities = 82/330 (24%), Positives = 130/330 (39%), Gaps = 56/330 (16%) Query: 50 RPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ-------DKRFKNRELQIMR 102 + + Y KVIG G+FG V + S ++ A+K + + D F E IM Sbjct: 84 QMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMA 143 Query: 103 KLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPET-VYRVARHYSRAKQTLPVIYVKLY 161 + +V+L Y F +D+ YL +V++Y+P + + +Y +P + K Y Sbjct: 144 FANSPWVVQLFYAF------QDDRYLYMVMEYMPGGDLVNLMSNYD-----VPEKWAKFY 192 Query: 162 MYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGE--PNVSYICS 219 ++ +L IHS G+ HRD+KP N+LLD LKL DFG+ ++ + + + Sbjct: 193 TAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGH-LKLADFGTCMKMDETGMVHCDTAVGT 251 Query: 220 RYYRAPELIFGATD---YTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTP 276 Y +PE++ Y D WS G L E+L+G F DS V +I+ + Sbjct: 252 PDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSL 311 Query: 277 TREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARL---TPLE 333 FP+ A L L RL E Sbjct: 312 C---------------FPE----------DAEISKHAKNLICAFLT-DREVRLGRNGVEE 345 Query: 334 ACAHSFFD--ELRDPNVKLPNGRDTPALFN 361 H FF + N++ P L + Sbjct: 346 IRQHPFFKNDQWHWDNIRETAAPVVPELSS 375 >5F9E-A nrPDB Length = 353 Score = 230 bits (586), Expect = 1e-60, Method: Composition-based stats. Identities = 80/343 (23%), Positives = 139/343 (40%), Gaps = 58/343 (16%) Query: 50 RPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNR-------ELQIMR 102 + + + K++G GSFG V+ A+ + + AIK + +D + E +++ Sbjct: 15 KLKIEDFELHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLS 74 Query: 103 KL-DHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLY 161 +H + + F + + L V++Y+ ++ ++ + Y Sbjct: 75 LAWEHPFLTHMFCTF------QTKENLFFVMEYLNGG---DLMYHIQSCHKFDLSRATFY 125 Query: 162 MYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVS-YICSR 220 ++ L ++HS GI +RD+K N+LLD D +K+ DFG K+ + G+ + + + Sbjct: 126 AAEIILGLQFLHSKGIVYRDLKLDNILLDKDGH-IKIADFGMCKENMLGDAKTNEFCGTP 184 Query: 221 YYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQ 280 Y APE++ G Y S+D WS G +L E+L+GQ F G + Sbjct: 185 DYIAPEILLG-QKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEE------------LFHS 231 Query: 281 IREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPL-EACAHSF 339 IR NP Y W + EA L +L P RL + H Sbjct: 232 IRMDNPFYPR----------WLE-------KEAKDLLVKLFVREPEKRLGVRGDIRQHPL 274 Query: 340 F-----DELRDPNVKLPNGRDTPALF---NFTTQELSSNPPLA 374 F +EL + P + F NF + L+ P L+ Sbjct: 275 FREINWEELERKEIDPPFRPKVKSPFDCSNFDKEFLNEKPRLS 317 >3ORZ-A nrPDB Length = 316 Score = 229 bits (585), Expect = 2e-60, Method: Composition-based stats. Identities = 81/309 (26%), Positives = 130/309 (42%), Gaps = 56/309 (18%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN-------RELQIMRKLDHC 107 + K++G GSF V A+ + AIK + + K RE +M +LDH Sbjct: 38 DFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHP 97 Query: 108 NIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFR 167 V+L + F +D+ L L Y Y R + + Y ++ Sbjct: 98 FFVKLYFCF------QDDEKLYFGLSYAKNG---ELLKYIRKIGSFDETCTRFYTAEIVS 148 Query: 168 SLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNV---SYICSRYYRA 224 +L Y+H GI HRD+KP+N+LL+ D +++ DFG+AK L S++ + Y + Sbjct: 149 ALEYLHGKGIIHRDLKPENILLNEDMH-IQITDFGTAKVLSPESKQARANSFVGTAQYVS 207 Query: 225 PELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREM 284 PEL+ + S D+W+ GC++ +L+ G P F + +IIK+ Sbjct: 208 PELLTEKSA-CKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKL------------ 254 Query: 285 NPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLE------ACAHS 338 E+ FP+ + P+A L +LL T RL E AH Sbjct: 255 -----EYDFPE------------KFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHP 297 Query: 339 FFDELRDPN 347 FF+ + N Sbjct: 298 FFESVTWEN 306 >6E9W-A nrPDB Length = 443 Score = 229 bits (584), Expect = 2e-60, Method: Composition-based stats. Identities = 80/308 (25%), Positives = 124/308 (40%), Gaps = 54/308 (17%) Query: 50 RPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ-------DKRFKNRELQIMR 102 R + Y KVIG G+FG V + + ++ A+K + + D F E IM Sbjct: 98 RMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMA 157 Query: 103 KLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPET-VYRVARHYSRAKQTLPVIYVKLY 161 + +V+L Y F +D+ YL +V++Y+P + + +Y +P + + Y Sbjct: 158 FANSPWVVQLFYAF------QDDRYLYMVMEYMPGGDLVNLMSNYD-----VPEKWARFY 206 Query: 162 MYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNV--SYICS 219 ++ +L IHS G HRD+KP N+LLD LKL DFG+ ++ + + + + Sbjct: 207 TAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGH-LKLADFGTCMKMNKEGMVRCDTAVGT 265 Query: 220 RYYRAPELIF---GATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTP 276 Y +PE++ G Y D WS G L E+L+G F DS V +I+ + Sbjct: 266 PDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNS- 324 Query: 277 TREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARL---TPLE 333 FP EA L L RL E Sbjct: 325 --------------LTFPD----------DNDISKEAKNLICAFLT-DREVRLGRNGVEE 359 Query: 334 ACAHSFFD 341 H FF Sbjct: 360 IKRHLFFK 367 >3DAK-A nrPDB Length = 290 Score = 229 bits (583), Expect = 2e-60, Method: Composition-based stats. Identities = 69/307 (22%), Positives = 117/307 (38%), Gaps = 42/307 (13%) Query: 54 VSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDK-----RFKNRELQIMRKLDHCN 108 Y +VIG+G+ VV A E VAIK++ +K +E+Q M + H N Sbjct: 10 DDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHHPN 69 Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYV-PETVYRVARHYSRAKQ----TLPVIYVKLYMY 163 IV F E L LV+ + +V + +H + L + + Sbjct: 70 IVSYYTSFVVKDE------LWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILR 123 Query: 164 QLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAK------QLVRGEPNVSYI 217 ++ L Y+H G HRD+K N+LL D +V ++ DFG + + R + +++ Sbjct: 124 EVLEGLEYLHKNGQIHRDVKAGNILLGEDGSV-QIADFGVSAFLATGGDITRNKVRKTFV 182 Query: 218 CSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPT 277 + + APE++ Y D+WS G EL G + + L+ + Sbjct: 183 GTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTL------- 235 Query: 278 REQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAH 337 + P ++ K + + S L+ P R T E H Sbjct: 236 ------------QNDPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRH 283 Query: 338 SFFDELR 344 FF + + Sbjct: 284 KFFQKAK 290 >3RAW-A nrPDB Length = 381 Score = 228 bits (582), Expect = 3e-60, Method: Composition-based stats. Identities = 85/377 (22%), Positives = 146/377 (38%), Gaps = 62/377 (16%) Query: 19 QPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDS 78 Q S S V DK+G V + D QE Y +G G+FG V + Sbjct: 24 QSSKRSSRSVEDDKEGHLVCRI-------GDWLQE-RYEIVGNLGEGTFGKVVECLDHAR 75 Query: 79 GE-LVAIKKVL---QDKRFKNRELQIMRKL---DHCN---IVRLRYFFYSSGEKKDEVYL 128 G+ VA+K + + + E+ +++K+ D N V + +F G ++ Sbjct: 76 GKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHG------HM 129 Query: 129 NLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLL 188 + + + + + + Q P+ +V+ YQL +L ++H + H D+KP+N+L Sbjct: 130 CIAFELLGKNTFEFLKE--NNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENIL 187 Query: 189 L------------------DPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFG 230 +++ DFGSA E + + + +R+YR PE+I Sbjct: 188 FVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSAT--FDHEHHTTIVATRHYRPPEVILE 245 Query: 231 ATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIRE------- 283 + DVWS GC+L E G +F + LV + K+LG I Sbjct: 246 L-GWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYF 304 Query: 284 ------MNPNYTEFKFPQIKAHPWTKVFRPRTPP--EAIALCSRLLEYTPTARLTPLEAC 335 + N ++ ++ + P + + L R+LE+ P R+T EA Sbjct: 305 YKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEAL 364 Query: 336 AHSFFDELRDPNVKLPN 352 H FF L Sbjct: 365 LHPFFAGLTPEERSFHT 381 >4YNZ-A nrPDB Length = 342 Score = 228 bits (582), Expect = 3e-60, Method: Composition-based stats. Identities = 84/332 (25%), Positives = 135/332 (40%), Gaps = 51/332 (15%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDK------RFKNRELQIMRKLDHCNI 109 Y K +G G G+V C + + VAIK V ++K RE+ I++ ++H ++ Sbjct: 12 YRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHV 71 Query: 110 VRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 169 ++L + +++ YL LVL++V Y K L + + Q+ +L Sbjct: 72 LKLHDVY------ENKKYLYLVLEHVSGGELF---DYLVKKGRLTPKEARKFFRQIISAL 122 Query: 170 AYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIF 229 + HS ICHRD+KP+NLLLD +++ DFG A V + S +Y PE+I Sbjct: 123 DFCHSHSICHRDLKPENLLLDERNN-IRIADFGMASLQVGDSLLETSCGSPHYACPEVIR 181 Query: 230 GATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYT 289 G DVWS G +L LL+G F D+ L ++ + + Sbjct: 182 GEKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGV---------------- 225 Query: 290 EFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF---DELRDP 346 F P PP+ +L ++E RLT H ++ +P Sbjct: 226 -FHMPHF------------IPPDCQSLLRGMIEVDAARRLTLEHIQKHIWYIGGKNEPEP 272 Query: 347 NVKLPNG---RDTPALFNFTTQELSSNPPLAT 375 +P R P+L + L S L Sbjct: 273 EQPIPRKVQIRSLPSLEDIDPDVLDSMHSLGC 304 >2UV2-A nrPDB Length = 325 Score = 228 bits (582), Expect = 3e-60, Method: Composition-based stats. Identities = 70/296 (23%), Positives = 114/296 (38%), Gaps = 44/296 (14%) Query: 53 EVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNR----ELQIMRKLDHCN 108 E + +G+G+FG VY+A+ ++ L A K + + E+ I+ DH N Sbjct: 36 EDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDHPN 95 Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRS 168 IV+L FY E L +++++ ++ L +++ Q + Sbjct: 96 IVKLLDAFYY------ENNLWILIEFCAGGAVDAVM--LELERPLTESQIQVVCKQTLDA 147 Query: 169 LAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNV-SYICSRYYRAPEL 227 L Y+H I HRD+K N+L D +KL DFG + + R S+I + Y+ APE+ Sbjct: 148 LNYLHDNKIIHRDLKAGNILFTLDGD-IKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEV 206 Query: 228 IF----GATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIRE 283 + Y DVWS G L E+ +P + + L++I K Sbjct: 207 VMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAK------------ 254 Query: 284 MNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSF 339 + P T R + LE AR T + H F Sbjct: 255 --------------SEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPF 296 >3NYO-A nrPDB Length = 576 Score = 227 bits (580), Expect = 5e-60, Method: Composition-based stats. Identities = 77/301 (25%), Positives = 129/301 (42%), Gaps = 46/301 (15%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ-------DKRFKNRELQIMRKLDHC 107 ++ +V+G G FG V ++ +G++ A KK+ + + E QI+ K++ Sbjct: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSR 244 Query: 108 NIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFR 167 +V L Y + E KD + L L L + + + Y + P Y ++ Sbjct: 245 FVVSLAYAY----ETKDALCLVLTLMNGGDLKFHI---YHMGQAGFPEARAVFYAAEICC 297 Query: 168 SLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPEL 227 L +H I +RD+KP+N+LLD D +++ D G A + G+ + + Y APE+ Sbjct: 298 GLEDLHRERIVYRDLKPENILLD-DHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEV 356 Query: 228 IFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPN 287 + YT S D W+ GC+L E++ GQ F K+ ++E+ Sbjct: 357 VKNER-YTFSPDWWALGCLLYEMIAGQSPFQ--------QRKKKIKREEVERLVKEVPEE 407 Query: 288 YTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARL-----TPLEACAHSFFDE 342 Y+E R P+A +LCS+LL P RL + E H F + Sbjct: 408 YSE-----------------RFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKK 450 Query: 343 L 343 L Sbjct: 451 L 451 >6HXF-B nrPDB Length = 302 Score = 227 bits (580), Expect = 5e-60, Method: Composition-based stats. Identities = 69/298 (23%), Positives = 123/298 (41%), Gaps = 44/298 (14%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNR----ELQIMRKLDHCNIVR 111 + +G+G+FG VY+AK ++G L A K + + E++I+ DH IV+ Sbjct: 21 WEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDHPYIVK 80 Query: 112 LRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAY 171 L +Y G+ L +++++ P + L +++ Q+ +L + Sbjct: 81 LLGAYYHDGK------LWIMIEFCPGGAVDAIM--LELDRGLTEPQIQVVCRQMLEALNF 132 Query: 172 IHSFGICHRDIKPQNLLLDPDTAVLKLCDFG-SAKQLVRGEPNVSYICSRYYRAPELI-- 228 +HS I HRD+K N+L+ + ++L DFG SAK L + S+I + Y+ APE++ Sbjct: 133 LHSKRIIHRDLKAGNVLMTLEGD-IRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMC 191 Query: 229 --FGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNP 286 T Y D+WS G L E+ +P + + L++I K Sbjct: 192 ETMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAK--------------- 236 Query: 287 NYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELR 344 + P T + + E L+ P R + + H F + Sbjct: 237 -----------SDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSIT 283 >2HW6-A nrPDB Length = 307 Score = 227 bits (580), Expect = 6e-60, Method: Composition-based stats. Identities = 75/316 (23%), Positives = 134/316 (42%), Gaps = 44/316 (13%) Query: 48 PDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ----DKRFKNRELQIMRK 103 P + +++ ++++G G++ V A +G+ A+K + + + RE++ + + Sbjct: 7 PGKFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQ 66 Query: 104 LD-HCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYM 162 + NI+ L FF +D+ LV + + + + ++ + Sbjct: 67 CQGNKNILELIEFF------EDDTRFYLVFEKLQGGS---ILAHIQKQKHFNEREASRVV 117 Query: 163 YQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAV--LKLCDF--GSAKQLVRG------EP 212 + +L ++H+ GI HRD+KP+N+L + V +K+CDF GS +L Sbjct: 118 RDVAAALDFLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPE 177 Query: 213 NVSYICSRYYRAPELIF----GATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVD---Q 265 + S Y APE++ AT Y D+WS G VL +L G P F G G D Sbjct: 178 LTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWD 237 Query: 266 LVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTP 325 E+ +V E I+E +++FP W + EA L S+LL Sbjct: 238 RGEVCRVCQNKLFESIQE-----GKYEFPD---KDWAHI-----SSEAKDLISKLLVRDA 284 Query: 326 TARLTPLEACAHSFFD 341 RL+ + H + Sbjct: 285 KQRLSAAQVLQHPWVQ 300 >6CMJ-A nrPDB Length = 321 Score = 227 bits (579), Expect = 7e-60, Method: Composition-based stats. Identities = 76/322 (23%), Positives = 126/322 (39%), Gaps = 56/322 (17%) Query: 52 QEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN---------------R 96 Q YT IG GS+GVV A + A+K + + K + + Sbjct: 32 QLDQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGGCIQPRGPIEQVYQ 91 Query: 97 ELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVI 156 E+ I++KLDH N+V+L + +E +L +V + V + + L Sbjct: 92 EIAILKKLDHPNVVKLVEVL----DDPNEDHLYMVFELVNQG----PVMEVPTLKPLSED 143 Query: 157 YVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVS- 215 + Y L + + Y+H I HRDIKP NLL+ D +K+ DFG + + + +S Sbjct: 144 QARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGH-IKIADFGVSNEFKGSDALLSN 202 Query: 216 YICSRYYRAPELIFGATDY--TSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVL 273 + + + APE + ++DVW+ G L + GQ F D + L IK Sbjct: 203 TVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPF-MDERIMCLHSKIKS- 260 Query: 274 GTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLE 333 +FP +P + L +R+L+ P +R+ E Sbjct: 261 ---------------QALEFPD----------QPDIAEDLKDLITRMLDKNPESRIVVPE 295 Query: 334 ACAHSFFDELRDPNVKLPNGRD 355 H + R LP+ + Sbjct: 296 IKLHPWVT--RHGAEPLPSEDE 315 >5X3F-B nrPDB Length = 393 Score = 227 bits (578), Expect = 8e-60, Method: Composition-based stats. Identities = 79/376 (21%), Positives = 143/376 (38%), Gaps = 64/376 (17%) Query: 11 AESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVV 70 ++S + + ++ K TP Q + Q + K +G GSFG V Sbjct: 43 SQSANLLAEAKKLNDVQAFLAKAKEDFLKKWETPSQ--NTAQLDQFDRIKTLGTGSFGRV 100 Query: 71 YQAKLCDSGELVAIKKVLQDKRFKNR-------ELQIMRKLDHCNIVRLRYFFYSSGEKK 123 K +SG A+K + + K K + E +I++ ++ +V+L + F K Sbjct: 101 MLVKHKESGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSF------K 154 Query: 124 DEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIK 183 D L +V++YV + H R + + + Y Q+ + Y+HS + +RD+K Sbjct: 155 DNSNLYMVMEYVAGG--EMFSHLRRIGR-FSEPHARFYAAQIVLTFEYLHSLDLIYRDLK 211 Query: 184 PQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSA 243 P+NLL+D +++ DFG AK++ + + Y APE+I Y ++D W+ Sbjct: 212 PENLLIDQQGY-IQVTDFGFAKRVK--GRTWTLCGTPEYLAPEIILS-KGYNKAVDWWAL 267 Query: 244 GCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTK 303 G ++ E+ G P F D + +I+ + +FP Sbjct: 268 GVLIYEMAAGYPPFFADQPIQIYEKIVS-----------------GKVRFPS-------- 302 Query: 304 VFRPRTPPEAIALCSRLLEYTPTARL-----TPLEACAHSFFD--------ELRDPNVKL 350 + L LL+ T R + H +F + + + Sbjct: 303 ----HFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFI 358 Query: 351 PNGRDTPALFNFTTQE 366 P + NF E Sbjct: 359 PKFKGPGDTSNFDDYE 374 >3Q53-A nrPDB Length = 306 Score = 227 bits (578), Expect = 9e-60, Method: Composition-based stats. Identities = 69/301 (22%), Positives = 124/301 (41%), Gaps = 43/301 (14%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNR----ELQIMRKLDHCNIVR 111 YT + IG G+ G VY A +G+ VAI+++ ++ K E+ +MR+ + NIV Sbjct: 23 YTRFEKIGQGASGTVYTAMDVATGQEVAIRQMNLQQQPKKELIINEILVMRENKNPNIVN 82 Query: 112 LRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAY 171 + E L +V++Y+ + + + + ++L + Sbjct: 83 YLDSYLVGDE------LWVVMEYLAGGSLTDVV----TETCMDEGQIAAVCRECLQALEF 132 Query: 172 IHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSY-ICSRYYRAPELIFG 230 +HS + HRDIK N+LL D +V KL DFG Q+ + S + + Y+ APE++ Sbjct: 133 LHSNQVIHRDIKSDNILLGMDGSV-KLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVT- 190 Query: 231 ATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTE 290 Y +D+WS G + E++ G+P + ++ + L I GTP + +++ + Sbjct: 191 RKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLI-ATNGTPELQNPEKLSAIF-- 247 Query: 291 FKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKL 350 +R LE R + E H F + + Sbjct: 248 -----------------------RDFLNRCLEMDVEKRGSAKELIQHQFLKIAKPLSSLT 284 Query: 351 P 351 P Sbjct: 285 P 285 >3FXW-A nrPDB Length = 336 Score = 227 bits (578), Expect = 9e-60, Method: Composition-based stats. Identities = 78/305 (25%), Positives = 134/305 (43%), Gaps = 34/305 (11%) Query: 45 GQGPDRPQE---VSYTDTK-VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQI 100 QGP+ + Y +K V+G G G V + +G+ A+K +L D +E+ Sbjct: 16 FQGPEPKKYAVTDDYQLSKQVLGLGVNGKVLECFHRRTGQKCALK-LLYDSPKARQEVDH 74 Query: 101 MRKLDH-CNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVK 159 + +IV + + + + L ++++ + +R R Q Sbjct: 75 HWQASGGPHIVCILDVYENM--HHGKRCLLIIMECMEGGEL-FSRIQERGDQAFTEREAA 131 Query: 160 LYMYQLFRSLAYIHSFGICHRDIKPQNLLLD--PDTAVLKLCDFGSAKQLVRGEPNVSYI 217 M + ++ ++HS I HRD+KP+NLL AVLKL DFG AK+ + + Sbjct: 132 EIMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQN-ALQTPC 190 Query: 218 CSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPT 277 + YY APE++ G Y S D+WS G ++ LL G P F ++G + + Sbjct: 191 YTPYYVAPEVL-GPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTG--------QAISPGM 241 Query: 278 REQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAH 337 + +IR ++ FP + W++V +A L LL+ PT RLT + H Sbjct: 242 KRRIRL-----GQYGFPNPE---WSEV-----SEDAKQLIRLLLKTDPTERLTITQFMNH 288 Query: 338 SFFDE 342 + ++ Sbjct: 289 PWINQ 293 >6E2O-A nrPDB Length = 295 Score = 226 bits (576), Expect = 2e-59, Method: Composition-based stats. Identities = 75/308 (24%), Positives = 119/308 (38%), Gaps = 43/308 (13%) Query: 45 GQGPDRPQEVSYTDTK-----VIGNGSFGVVYQAKLCDSGELVAIKKVLQ-DKRFKN--- 95 G E Y + V+G G++G+VY + + +AIK++ + D R+ Sbjct: 8 GDCESDLLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLH 67 Query: 96 RELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPV 155 E+ + + L H NIV+ F +G ++ + ++ VP Sbjct: 68 EEIALHKHLKHKNIVQYLGSFSENG------FIKIFMEQVPGGSLSALLRSKWGPLKDNE 121 Query: 156 IYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNV- 214 + Y Q+ L Y+H I HRDIK N+L++ + VLK+ DFG++K+L P Sbjct: 122 QTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTE 181 Query: 215 SYICSRYYRAPELI-FGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVL 273 ++ + Y APE+I G Y + D+WS GC + E+ G+P F Sbjct: 182 TFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFY--------------- 226 Query: 274 GTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLE 333 P FK K HP EA A + E P R + Sbjct: 227 --------ELGEPQAAMFKVGMFKVHP---EIPESMSAEAKAFILKCFEPDPDKRACAND 275 Query: 334 ACAHSFFD 341 F Sbjct: 276 LLVDEFLK 283 >5N23-A nrPDB Length = 352 Score = 226 bits (575), Expect = 2e-59, Method: Composition-based stats. Identities = 80/368 (21%), Positives = 142/368 (38%), Gaps = 63/368 (17%) Query: 21 SAFGSMKVSRDKDGSKVTTVVATPGQGP--DRPQEVSYTDTKVIGNGSFGVVYQAKLCDS 78 + GS + S + +K + P + + + +G GSFG V K ++ Sbjct: 7 AKKGSEQESVKEFLAKAKEDFLKKWESPAQNTAHLDQFERIRTLGTGSFGRVMLVKHKET 66 Query: 79 GELVAIKKVLQDKRFKNR-------ELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLV 131 G A+K + + K K + E +I + ++ +V+L + F KD L +V Sbjct: 67 GNHYAMKILDKQKVVKLKQIEHTLNEKRIQQAVNFPFLVKLEFSF------KDNSNLYMV 120 Query: 132 LDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDP 191 L+Y P + H R + + + Y Q+ + Y+HS + +RD+KP+NLL+D Sbjct: 121 LEYAPGG--EMFSHLRRIGR-FSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQ 177 Query: 192 DTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELL 251 +K+ DFG AK+ V+G + + Y APE+I Y ++D W+ G ++ E+ Sbjct: 178 QGY-IKVADFGFAKR-VKGRTPWTLCGTPEYLAPEIILS-KGYNKAVDWWALGVLIYEMA 234 Query: 252 LGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPP 311 G P F D + +I+ + +FP Sbjct: 235 AGYPPFFADQPIQIYEKIVS-----------------GKVRFPS------------HFSS 265 Query: 312 EAIALCSRLLEYTPTARL-----TPLEACAHSFFD--------ELRDPNVKLPNGRDTPA 358 + L LL+ T R + H +F + + +P + Sbjct: 266 DLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGD 325 Query: 359 LFNFTTQE 366 NF E Sbjct: 326 TSNFDDYE 333 >3TKU-A nrPDB Length = 433 Score = 226 bits (575), Expect = 2e-59, Method: Composition-based stats. Identities = 81/336 (24%), Positives = 135/336 (40%), Gaps = 56/336 (16%) Query: 50 RPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN-------RELQIMR 102 + + KVIG G+FG V K+ ++ + A+K + + + K E ++ Sbjct: 86 QLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLV 145 Query: 103 KLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYM 162 D I L Y F +DE +L LV+DY + S+ + LP + Y+ Sbjct: 146 NGDCQWITALHYAF------QDENHLYLVMDYYVGG--DLLTLLSKFEDKLPEDMARFYI 197 Query: 163 YQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYI--CSR 220 ++ ++ IH HRDIKP N+LLD + ++L DFGS ++ S + + Sbjct: 198 GEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGH-IRLADFGSCLKMNDDGTVQSSVAVGTP 256 Query: 221 YYRAPELIF----GATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTP 276 Y +PE++ G Y D WS G + E+L G+ F +S V+ +I+ Sbjct: 257 DYISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMN----- 311 Query: 277 TREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARL---TPLE 333 + F+FP EA L RL+ + RL + Sbjct: 312 ----------HEERFQFPS---------HVTDVSEEAKDLIQRLIC-SRERRLGQNGIED 351 Query: 334 ACAHSFFDELRDPNVK------LPNGRDTPALFNFT 363 H+FF+ L N++ +P+ NF Sbjct: 352 FKKHAFFEGLNWENIRNLEAPYIPDVSSPSDTSNFD 387 >1VZO-A nrPDB Length = 355 Score = 224 bits (572), Expect = 4e-59, Method: Composition-based stats. Identities = 84/342 (24%), Positives = 145/342 (42%), Gaps = 63/342 (18%) Query: 49 DRPQEVSYTDTKVIGNGSFGVVYQAKLC---DSGELVAIKKVLQ--------DKRFKNRE 97 ++ ++ KV+G G++G V+ + D+G+L A+K + + E Sbjct: 49 EKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTE 108 Query: 98 LQIMRKL-DHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVI 156 Q++ + +V L Y F + E L+L+LDY+ + H S+ ++ Sbjct: 109 RQVLEHIRQSPFLVTLHYAF------QTETKLHLILDYINGG--ELFTHLSQ-RERFTEH 159 Query: 157 YVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPN--V 214 V++Y+ ++ +L ++H GI +RDIK +N+LLD + V+ L DFG +K+ V E Sbjct: 160 EVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVV-LTDFGLSKEFVADETERAY 218 Query: 215 SYICSRYYRAPELIF-GATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVL 273 + + Y AP+++ G + + ++D WS G ++ ELL G F D + EI + Sbjct: 219 DFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISR-- 276 Query: 274 GTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARL---- 329 +I + P Y + A L RLL P RL Sbjct: 277 ------RILKSEPPYPQ-----------------EMSALAKDLIQRLLMKDPKKRLGCGP 313 Query: 330 -TPLEACAHSFFDEL--------RDPNVKLPNGRDTPALFNF 362 E H FF ++ + P P RD + NF Sbjct: 314 RDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDELDVSNF 355 >5J5T-A nrPDB Length = 370 Score = 224 bits (572), Expect = 4e-59, Method: Composition-based stats. Identities = 67/298 (22%), Positives = 115/298 (38%), Gaps = 41/298 (13%) Query: 52 QEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVL----QDKRFKNRELQIMRKLDHC 107 + + + IG+G++G VY+A+ ++GEL AIK + +D +E+ +M+ H Sbjct: 2 SQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKHP 61 Query: 108 NIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFR 167 NIV + + L + +++ + H + L + + + + Sbjct: 62 NIVAYFGSYLRRDK------LWICMEFCGGGSLQDIYHVT---GPLSELQIAYVSRETLQ 112 Query: 168 SLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRG-EPNVSYICSRYYRAPE 226 L Y+HS G HRDIK N+LL + V KL DFG + Q+ ++I + Y+ APE Sbjct: 113 GLYYLHSKGKMHRDIKGANILLTDNGHV-KLADFGVSAQITATIAKRKAFIGTPYWMAPE 171 Query: 227 L--IFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREM 284 + + Y D+W+ G EL QP + L + K P + + Sbjct: 172 VAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLK---- 227 Query: 285 NPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDE 342 W+ F L P R T + H F + Sbjct: 228 ------------DKMKWSNSFH--------HFVKMALTKNPKKRPTAEKLLQHPFVTQ 265 >4WB7-A nrPDB Length = 405 Score = 224 bits (570), Expect = 7e-59, Method: Composition-based stats. Identities = 73/338 (21%), Positives = 132/338 (39%), Gaps = 62/338 (18%) Query: 49 DRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNR-------ELQIM 101 + + K +G GSFG V K ++G A+K + + K K + E +I+ Sbjct: 91 NTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRIL 150 Query: 102 RKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLY 161 + ++ +V+L + F KD L +V++YVP + H R + + + Y Sbjct: 151 QAVNFPFLVKLEFSF------KDNSNLYMVMEYVPGG--EMFSHLRRIGR-FSEPHARFY 201 Query: 162 MYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY 221 Q+ + Y+HS + +RD+KP+NLL+D +++ DFG AK++ + + Sbjct: 202 AAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY-IQVTDFGFAKRVK--GRTWTLCGTPE 258 Query: 222 YRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQI 281 Y APE+I Y ++D W+ G ++ E+ G P F D + +I+ Sbjct: 259 YLAPEIILS-KGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVS---------- 307 Query: 282 REMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARL-----TPLEACA 336 + +FP + L LL+ T R + Sbjct: 308 -------GKVRFPS------------HFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKN 348 Query: 337 HSFFD--------ELRDPNVKLPNGRDTPALFNFTTQE 366 H +F + + +P + NF E Sbjct: 349 HKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYE 386 >5DBX-A nrPDB Length = 328 Score = 223 bits (568), Expect = 1e-58, Method: Composition-based stats. Identities = 67/311 (21%), Positives = 117/311 (37%), Gaps = 42/311 (13%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDK-----RFKNRELQIMRKLDHCNIV 110 Y +VIG+G+ VV A E VAIK++ +K +E+Q M + H N+V Sbjct: 13 YELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQCSHPNVV 72 Query: 111 RLRYFFYSSGEKKDEVYLNLVLDYV-PETVYRVARHYSRAKQ----TLPVIYVKLYMYQL 165 F E L LV+ + ++ + ++ + L + + ++ Sbjct: 73 TYYTSFVVKDE------LWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEV 126 Query: 166 FRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEP------NVSYICS 219 L Y+H G HRD+K N+LL D +V ++ DFG + L G ++ + Sbjct: 127 LEGLDYLHRNGQIHRDLKAGNILLGEDGSV-QIADFGVSAFLATGGDVTRNKVRKDFVGT 185 Query: 220 RYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTRE 279 + APE++ Y D+WS G EL G + + L+ + Sbjct: 186 PCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTL--------- 236 Query: 280 QIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSF 339 + P ++ K + L S L+ P+ R T E F Sbjct: 237 ----------QNDPPTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKF 286 Query: 340 FDELRDPNVKL 350 F + ++ + Sbjct: 287 FQKAKNREYLI 297 >2XIK-A nrPDB Length = 294 Score = 222 bits (567), Expect = 2e-58, Method: Composition-based stats. Identities = 70/301 (23%), Positives = 113/301 (37%), Gaps = 47/301 (15%) Query: 50 RPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKV-----LQDKRFKNRELQIMRKL 104 P+E+ +T IG GSFG VY+ + E+VAIK + + +E+ ++ + Sbjct: 16 DPEEL-FTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQC 74 Query: 105 DHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQ 164 D I R + S + L ++++Y+ L Y+ + + Sbjct: 75 DSPYITRYFGSYLKSTK------LWIIMEYLGGGSALDLLK----PGPLEETYIATILRE 124 Query: 165 LFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGE-PNVSYICSRYYR 223 + + L Y+HS HRDIK N+LL V KL DFG A QL + +++ + ++ Sbjct: 125 ILKGLDYLHSERKIHRDIKAANVLLSEQGDV-KLADFGVAGQLTDTQIKRNTFVGTPFWM 183 Query: 224 APELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIRE 283 APE+I + Y D+WS G EL G+P + L I Sbjct: 184 APEVI-KQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLI-------------- 228 Query: 284 MNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDEL 343 P + + P+ + L P R T E H F Sbjct: 229 --PKNSPPTLEGQHSKPFKE------------FVEACLNKDPRFRPTAKELLKHKFITRY 274 Query: 344 R 344 Sbjct: 275 T 275 >1U5R-A nrPDB Length = 348 Score = 222 bits (566), Expect = 2e-58, Method: Composition-based stats. Identities = 81/319 (25%), Positives = 137/319 (42%), Gaps = 50/319 (15%) Query: 47 GPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKV----LQDKRFKN---RELQ 99 D P+++ ++D + IG+GSFG VY A+ + E+VAIKK+ Q +E++ Sbjct: 48 FKDDPEKL-FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVR 106 Query: 100 IMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVK 159 ++KL H N ++ R + LV++Y + + + K+ L + + Sbjct: 107 FLQKLRHPNTIQYRGCYLREHTA------WLVMEYCLGSASDLLEVH---KKPLQEVEIA 157 Query: 160 LYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICS 219 + + LAY+HS + HRD+K N+LL + ++KL DFGSA + P S++ + Sbjct: 158 AVTHGALQGLAYLHSHNMIHRDVKAGNILL-SEPGLVKLGDFGSASIMA---PANSFVGT 213 Query: 220 RYYRAPELIF--GATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPT 277 Y+ APE+I Y +DVWS G EL +P + + L I Sbjct: 214 PYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHI-------- 265 Query: 278 REQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAH 337 + + P +++ W++ FR L+ P R T H Sbjct: 266 -----------AQNESPALQSGHWSEYFR--------NFVDSCLQKIPQDRPTSEVLLKH 306 Query: 338 SFFDELRDPNVKLPNGRDT 356 F R P V + + T Sbjct: 307 RFVLRERPPTVIMDLIQRT 325 >2GCD-A nrPDB Length = 309 Score = 222 bits (566), Expect = 2e-58, Method: Composition-based stats. Identities = 81/319 (25%), Positives = 137/319 (42%), Gaps = 50/319 (15%) Query: 47 GPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKV----LQDKRFKN---RELQ 99 D P+++ ++D + IG+GSFG VY A+ + E+VAIKK+ Q +E++ Sbjct: 9 FKDDPEKL-FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVR 67 Query: 100 IMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVK 159 ++KL H N ++ R + LV++Y + + + K+ L + + Sbjct: 68 FLQKLRHPNTIQYRGCYLREHTA------WLVMEYCLGSASDLLEVH---KKPLQEVEIA 118 Query: 160 LYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICS 219 + + LAY+HS + HRD+K N+LL + ++KL DFGSA + P S++ + Sbjct: 119 AVTHGALQGLAYLHSHNMIHRDVKAGNILL-SEPGLVKLGDFGSASIMA---PANSFVGT 174 Query: 220 RYYRAPELIF--GATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPT 277 Y+ APE+I Y +DVWS G EL +P + + L I Sbjct: 175 PYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHI-------- 226 Query: 278 REQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAH 337 + + P +++ W++ FR L+ P R T H Sbjct: 227 -----------AQNESPALQSGHWSEYFR--------NFVDSCLQKIPQDRPTSEVLLKH 267 Query: 338 SFFDELRDPNVKLPNGRDT 356 F R P V + + T Sbjct: 268 RFVLRERPPTVIMDLIQRT 286 >4QMW-A nrPDB Length = 310 Score = 221 bits (564), Expect = 3e-58, Method: Composition-based stats. Identities = 67/297 (22%), Positives = 117/297 (39%), Gaps = 47/297 (15%) Query: 50 RPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKV-----LQDKRFKNRELQIMRKL 104 P+E+ +T + IG GSFG V++ + ++VAIK + + +E+ ++ + Sbjct: 26 DPEEL-FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQC 84 Query: 105 DHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQ 164 D + + + + L ++++Y+ L + + + Sbjct: 85 DSPYVTKYYGSYLKDTK------LWIIMEYLGGGSALDLLE----PGPLDETQIATILRE 134 Query: 165 LFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGE-PNVSYICSRYYR 223 + + L Y+HS HRDIK N+LL V KL DFG A QL + +++ + ++ Sbjct: 135 ILKGLDYLHSEKKIHRDIKAANVLLSEHGEV-KLADFGVAGQLTDTQIKRNTFVGTPFWM 193 Query: 224 APELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIRE 283 APE+I + Y S D+WS G EL G+P S + +KVL + Sbjct: 194 APEVI-KQSAYDSKADIWSLGITAIELARGEPP---HSELHP----MKVLFLIPKNNPPT 245 Query: 284 MNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF 340 + NY++ L P+ R T E H F Sbjct: 246 LEGNYSKP---------------------LKEFVEACLNKEPSFRPTAKELLKHKFI 281 >5YV8-A nrPDB Length = 298 Score = 221 bits (564), Expect = 4e-58, Method: Composition-based stats. Identities = 75/331 (22%), Positives = 124/331 (37%), Gaps = 69/331 (20%) Query: 42 ATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN------ 95 + G D Q YT IG GS+GVV A + A+K + + K + Sbjct: 1 GSSGSSGDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRR 60 Query: 96 ------------------------RELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLV 131 +E+ I++KLDH N+V+L + +E +L +V Sbjct: 61 PPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVL----DDPNEDHLYMV 116 Query: 132 LDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDP 191 + V + + L + Y L + + Y+H I HRDIKP NLL+ Sbjct: 117 FELVNQG----PVMEVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGE 172 Query: 192 DTAVLKLCDFGSAKQLVRGEPNVS-YICSRYYRAPELIFGATDY--TSSIDVWSAGCVLA 248 D +K+ DFG + + + +S + + + APE + ++DVW+ G L Sbjct: 173 DGH-IKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLY 231 Query: 249 ELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPR 308 + GQ F D + L IK +FP +P Sbjct: 232 CFVFGQCPF-MDERIMCLHSKIKS----------------QALEFPD----------QPD 264 Query: 309 TPPEAIALCSRLLEYTPTARLTPLEACAHSF 339 + L +R+L+ P +R+ E H + Sbjct: 265 IAEDLKDLITRMLDKNPESRIVVPEIKLHPW 295 >4LFI-A nrPDB Length = 374 Score = 221 bits (563), Expect = 5e-58, Method: Composition-based stats. Identities = 89/340 (26%), Positives = 140/340 (41%), Gaps = 59/340 (17%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAI------------------------KK---- 86 Y +G G + V+Q DS + I K Sbjct: 41 DYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTT 100 Query: 87 --VLQDKRFKNRELQIMRKLD----------HCNIVRLRYFFYSSGEKKDEVYLNLVLDY 134 +D+ + N++ +++ + H NI+ L K LV +Y Sbjct: 101 LPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPA----LVFEY 156 Query: 135 VPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTA 194 V +R+ L + ++ YM++L ++L Y HS GI HRD+KP N+++D Sbjct: 157 VDNVDFRIL------YPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNK 210 Query: 195 VLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-G 253 L+L D+G A+ + SR+++ PEL+ Y S+D+WS G +LA ++ Sbjct: 211 KLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKR 270 Query: 254 QPIFPGDSGVDQLVEIIKVLGTPTREQI---REMNPNYTEFKFPQIKAHPWTKVFRPRT- 309 +P F G S DQLV+I+KVLGT E+ E+ + Q PW + Sbjct: 271 EPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNK 330 Query: 310 ----PPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRD 345 E I L LL Y RLT EA H +F +R+ Sbjct: 331 HLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIRE 370 >4TNB-A nrPDB Length = 590 Score = 221 bits (562), Expect = 7e-58, Method: Composition-based stats. Identities = 67/301 (22%), Positives = 123/301 (40%), Gaps = 46/301 (15%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNR-------ELQIMRKLDHC 107 ++ +V+G G FG V ++ +G++ A K++ + + K + E QI+ K++ Sbjct: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQ 244 Query: 108 NIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFR 167 +V L Y + E KD + L L + + + + Y+ Y ++ Sbjct: 245 FVVNLAYAY----ETKDALCLVLTIMNGGDLKFHI---YNMGNPGFEEERALFYAAEILC 297 Query: 168 SLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPEL 227 L +H +RD+KP+N+LLD D +++ D G A ++ G+ + + Y APE+ Sbjct: 298 GLEDLHHENTVYRDLKPENILLD-DYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEV 356 Query: 228 IFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPN 287 + Y S D W GC++ E++ GQ F G + E+ + + Sbjct: 357 L-NNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRV-------------- 401 Query: 288 YTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARL-----TPLEACAHSFFDE 342 +V+ + EA ++C LL RL E H FF Sbjct: 402 -----------LETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEEAAEVKRHPFFRN 450 Query: 343 L 343 + Sbjct: 451 M 451 >3HKO-A nrPDB Length = 345 Score = 220 bits (561), Expect = 8e-58, Method: Composition-based stats. Identities = 81/348 (23%), Positives = 130/348 (37%), Gaps = 84/348 (24%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ---------DKRFKNRELQIMRKLDH 106 Y IG GS+GVV A + + AIK + + D E+++M+KL H Sbjct: 28 YHLKGAIGQGSYGVVRVAIENQTRAIRAIKIMNKNKIRQINPKDVERIKTEVRLMKKLHH 87 Query: 107 CNIVRLRYFFYSSGEKKDEVYLNLVLDYV-PETVYRVARHYSR----------------- 148 NI RL + +DE Y+ LV++ + + Sbjct: 88 PNIARLYEVY------EDEQYICLVMELCHGGHLLDKLNVFIDDSTGKCAMDVVKTQICP 141 Query: 149 ---------------AKQTLP----VIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLL 189 +++L + M Q+F +L Y+H+ GICHRDIKP+N L Sbjct: 142 CPECNEEAINGSIHGFRESLDFVQREKLISNIMRQIFSALHYLHNQGICHRDIKPENFLF 201 Query: 190 DPDTA-VLKLCDFGSAKQLVRGEP-----NVSYICSRYYRAPELIFGATD-YTSSIDVWS 242 + + +KL DFG +K+ + + + Y+ APE++ + Y D WS Sbjct: 202 STNKSFEIKLVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEVLNTTNESYGPKCDAWS 261 Query: 243 AGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWT 302 AG +L LL+G FPG + D + +++ K + Sbjct: 262 AGVLLHLLLMGAVPFPGVNDADTISQVLN-------------------------KKLCFE 296 Query: 303 KVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKL 350 P A L S LL R + A H + + D K+ Sbjct: 297 NPNYNVLSPLARDLLSNLLNRNVDERFDAMRALQHPWISQFSDKIYKM 344 >3KN6-A nrPDB Length = 325 Score = 220 bits (561), Expect = 8e-58, Method: Composition-based stats. Identities = 71/303 (23%), Positives = 123/303 (40%), Gaps = 36/303 (11%) Query: 48 PDRPQEVSYTDT---KVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRF-KNRELQIMRK 103 D P Y K +G GSF + + S + A+K + + +E+ ++ Sbjct: 2 KDSPFYQHYDLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKL 61 Query: 104 LD-HCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYM 162 + H NIV+L F+ D+++ LV++ + + K+ M Sbjct: 62 CEGHPNIVKLHEVFH------DQLHTFLVMELLNGGELF---ERIKKKKHFSETEASYIM 112 Query: 163 YQLFRSLAYIHSFGICHRDIKPQNLLLD--PDTAVLKLCDFGSAKQLVRG-EPNVSYICS 219 +L +++++H G+ HRD+KP+NLL D +K+ DFG A+ +P + + Sbjct: 113 RKLVSAVSHMHDVGVVHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFT 172 Query: 220 RYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTRE 279 +Y APEL+ Y S D+WS G +L +L GQ F + T E Sbjct: 173 LHYAAPELL-NQNGYDESCDLWSLGVILYTMLSGQVPFQSHDR--------SLTCTSAVE 223 Query: 280 QIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSF 339 ++++ +F F + W V EA L LL P RL + + Sbjct: 224 IMKKIKK--GDFSF---EGEAWKNV-----SQEAKDLIQGLLTVDPNKRLKMSGLRYNEW 273 Query: 340 FDE 342 + Sbjct: 274 LQD 276 >5UNP-A nrPDB Length = 369 Score = 220 bits (560), Expect = 1e-57, Method: Composition-based stats. Identities = 84/374 (22%), Positives = 152/374 (40%), Gaps = 64/374 (17%) Query: 27 KVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAK-LCDSGELVAIK 85 V D +G + D QE Y +G G+FG V Q G VA+K Sbjct: 15 SVEDDAEGHLIY-------HVGDWLQE-RYEIVSTLGEGTFGRVVQCVDHRRGGARVALK 66 Query: 86 KVLQDKRFKNR---ELQIMRKL-----DHCNI-VRLRYFFYSSGEKKDEVYLNLVLDYVP 136 + +++K E+ ++ K+ D+ N+ V++ +F G ++ + + + Sbjct: 67 IIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHG------HMCISFELLG 120 Query: 137 ETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLL------- 189 + + + P+ V+ +QL +++ ++H + H D+KP+N+L Sbjct: 121 LSTFDFLKD--NNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYEL 178 Query: 190 -----------DPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSI 238 + +++ DFGSA E + + + +R+YRAPE+I ++ Sbjct: 179 TYNLEKKRDERSVKSTAVRVVDFGSAT--FDHEHHSTIVSTRHYRAPEVILEL-GWSQPC 235 Query: 239 DVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIRE-------------MN 285 DVWS GC++ E +G +F + L + ++LG IR+ + Sbjct: 236 DVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWD 295 Query: 286 PNYTEFKFPQIKAHPWTKVFRPRTPP--EAIALCSRLLEYTPTARLTPLEACAHSFFDEL 343 N + ++ + P + + L +LEY P RLT EA H FF L Sbjct: 296 ENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARL 355 Query: 344 R--DPNVKLPNGRD 355 R PN + RD Sbjct: 356 RAEPPNKLWDSSRD 369 >4AW2-A nrPDB Length = 437 Score = 219 bits (559), Expect = 1e-57, Method: Composition-based stats. Identities = 79/336 (23%), Positives = 132/336 (39%), Gaps = 56/336 (16%) Query: 50 RPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN-------RELQIMR 102 R + KVIG G+FG V KL ++ ++ A+K + + + K E ++ Sbjct: 70 RLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLV 129 Query: 103 KLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYM 162 D I L Y F +D+ L LV+DY + S+ + LP + Y+ Sbjct: 130 NGDSKWITTLHYAF------QDDNNLYLVMDYYVGG--DLLTLLSKFEDRLPEEMARFYL 181 Query: 163 YQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYI--CSR 220 ++ ++ +H HRDIKP N+L+D + ++L DFGS +L+ S + + Sbjct: 182 AEMVIAIDSVHQLHYVHRDIKPDNILMDMNGH-IRLADFGSCLKLMEDGTVQSSVAVGTP 240 Query: 221 YYRAPELIF----GATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTP 276 Y +PE++ G Y D WS G + E+L G+ F +S V+ +I+ Sbjct: 241 DYISPEILQAMEGGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMN----- 295 Query: 277 TREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARL---TPLE 333 + F+FP A L RL+ + RL + Sbjct: 296 ----------HKERFQFP---------TQVTDVSENAKDLIRRLIC-SREHRLGQNGIED 335 Query: 334 ACAHSFFDELRDPNVK------LPNGRDTPALFNFT 363 H FF + N++ +P NF Sbjct: 336 FKKHPFFSGIDWDNIRNCEAPYIPEVSSPTDTSNFD 371 >2JD5-A nrPDB Length = 373 Score = 219 bits (558), Expect = 2e-57, Method: Composition-based stats. Identities = 93/367 (25%), Positives = 158/367 (43%), Gaps = 57/367 (15%) Query: 43 TPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDK---RFKNRELQ 99 P + ++ Y + +G G F V+ AK + VA+K V DK E++ Sbjct: 8 HPAFKGEPYKDARYILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVRGDKVYTEAAEDEIK 67 Query: 100 IMRKLDHC-----------NIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSR 148 ++++++ +I++L F G + V++ +V + + E + + + Y Sbjct: 68 LLQRVNDADNTKEDSMGANHILKLLDHFNHKG--PNGVHVVMVFEVLGENLLALIKKY-- 123 Query: 149 AKQTLPVIYVKLYMYQLFRSLAYIHSF-GICHRDIKPQNLLLD-----PDTAVLKLCDFG 202 + +P+IYVK QL L Y+H GI H DIKP+N+L++ + +K+ D G Sbjct: 124 EHRGIPLIYVKQISKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLG 183 Query: 203 SAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSG 262 +A E + I +R YR+PE++ GA + D+WS C++ EL+ G +F D G Sbjct: 184 NA--CWYDEHYTNSIQTREYRSPEVLLGA-PWGCGADIWSTACLIFELITGDFLFEPDEG 240 Query: 263 V------DQLVEIIKVLGTPTREQIREMNPNYTEFKF---------PQIKAHPWTKV--- 304 D + +II++LG +R N YT F ++K P V Sbjct: 241 HSYTKDDDHIAQIIELLGELPSYLLR--NGKYTRTFFNSRGLLRNISKLKFWPLEDVLTE 298 Query: 305 ---FRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFD------ELRDPNVKL-PNGR 354 F E S +L+ P R H + E+R P+ +L +G Sbjct: 299 KYKFSKDEAKEISDFLSPMLQLDPRKRADAGGLVNHPWLKDTLGMEEIRVPDRELYGSGS 358 Query: 355 DTPALFN 361 D P F Sbjct: 359 DIPGWFE 365 >4U41-A nrPDB Length = 332 Score = 219 bits (558), Expect = 2e-57, Method: Composition-based stats. Identities = 66/300 (22%), Positives = 117/300 (39%), Gaps = 38/300 (12%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKV---LQDKRFKNRELQIMRKLDHC-NIVR 111 + +V+GNG++G VY+ + +G+L AIK + ++ E+ +++K H NI Sbjct: 26 FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKYSHHRNIAT 85 Query: 112 LRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAY 171 F + L LV+++ ++ TL ++ ++ R LA+ Sbjct: 86 YYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKG-NTLKEDWIAYISREILRGLAH 144 Query: 172 IHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRG-EPNVSYICSRYYRAPELIFG 230 +H + HRDIK QN+LL + V KL DFG + QL R ++I + Y+ APE+I Sbjct: 145 LHIHHVIHRDIKGQNVLLTENAEV-KLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIAC 203 Query: 231 ATD----YTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNP 286 + Y D+WS G E+ G P + L I Sbjct: 204 DENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLI----------------- 246 Query: 287 NYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDP 346 +P ++ + + + L R + + H F + + Sbjct: 247 ----------PRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNE 296 >5LOH-A nrPDB Length = 341 Score = 219 bits (557), Expect = 2e-57, Method: Composition-based stats. Identities = 76/361 (21%), Positives = 128/361 (35%), Gaps = 59/361 (16%) Query: 30 RDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ 89 ++ G T P P ++ K I G+FG VY + G+L A+K V + Sbjct: 12 KEPGGGAATEEGVNRIAVPKPPSIEEFSIVKPISRGAFGKVYLGQ--KGGKLYAVKVVKK 69 Query: 90 DKRF-------KNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRV 142 E + IV L Y S+ + LV++Y+ + Sbjct: 70 ADMINKNMTHQVQAERDALALSKSPFIVHLYYSLQSAN------NVYLVMEYLIGGDVKS 123 Query: 143 ARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFG 202 H Y+ ++ +L Y+H GI HRD+KP N+L+ + +KL DFG Sbjct: 124 LLHIYGY---FDEEMAVKYISEVALALDYLHRHGIIHRDLKPDNMLISNEGH-IKLTDFG 179 Query: 203 SAKQLVRGE-------PNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQP 255 +K + + ++ + Y APEL+ G + ++D W+ G L E L G P Sbjct: 180 LSKVTLNRDINMMDILTTRTFCGTPDYLAPELLLGRA-HGPAVDWWALGVCLFEFLTGIP 238 Query: 256 IFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIA 315 F ++ I+K + PW + + A + Sbjct: 239 PFNDETPQQVFQNILK-------------------------RDIPWPE-GEEKLSDNAQS 272 Query: 316 LCSRLLEYTPTARLTPLEACAHSFFDELRDPNVK------LPNGRDTPALFNFTTQELSS 369 LL T R E H F ++ N++ +P D F + + Sbjct: 273 AVEILLTIDDTKRAGMKELKRHPLFSDVDWENLQHQTMPFIPQPDDETDTSYFEARNTAQ 332 Query: 370 N 370 + Sbjct: 333 H 333 >4CSV-A nrPDB Length = 275 Score = 219 bits (557), Expect = 2e-57, Method: Composition-based stats. Identities = 67/300 (22%), Positives = 118/300 (39%), Gaps = 48/300 (16%) Query: 47 GPDRPQEV---SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ---DKRFKNRELQI 100 GP E+ T + +G+G FG VY+ K + VA+K + + +E QI Sbjct: 1 GPHDKWEIPRSEITLERKLGSGQFGEVYEGKWRNYNIEVAVKTLKEGTMSVEEFLQEAQI 60 Query: 101 MRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKL 160 M+KL H N+V+L E + ++ +Y+ T+ + Sbjct: 61 MKKLKHPNLVQLYGVCTK------EPPIYIITEYMSHGSLLDYLRDCEGH-TVNAQALLD 113 Query: 161 YMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSR 220 Q+ +AY+ S HRD+ +N L+ + V+K+ DFG A+ L+ + + ++ Sbjct: 114 MAAQVASGMAYLESQNFIHRDLAARNCLVGENN-VVKVADFGLAR-LINEDEYTARAGAK 171 Query: 221 Y---YRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTP 276 + + APE I ++ DVW+ G +L E+ GQ +PG SG + + ++ + P Sbjct: 172 FPIKWTAPEAI-SYNRFSIKSDVWAFGILLWEIFTYGQVPYPGMSGSEVIEQVERGYRMP 230 Query: 277 TREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACA 336 + P E L + +P R T E Sbjct: 231 RPQG----------------------------CPEEIYELMLQCWNKSPEERPTFAETLH 262 >6QAU-A nrPDB Length = 280 Score = 218 bits (556), Expect = 3e-57, Method: Composition-based stats. Identities = 72/304 (23%), Positives = 129/304 (42%), Gaps = 50/304 (16%) Query: 53 EVSYTDTKVIGNGSFGVVYQAKLC-DSGELVAIKKVLQDKRFKN-----RELQIMRKLDH 106 + Y+ ++G+G+F VV++ + + VAIK + + K+ +E++I+++L H Sbjct: 10 DFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKILKELQH 69 Query: 107 CNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLF 166 NIV L ++ + LV++Y Y +AK TL ++++++Q+ Sbjct: 70 ENIVALYDV------QELPNSVFLVMEYCNGG---DLADYLQAKGTLSEDTIRVFLHQIA 120 Query: 167 RSLAYIHSFGICHRDIKPQNLLLD--------PDTAVLKLCDFGSAKQLVRGEPNVSYIC 218 ++ +HS GI HRD+KPQN+LL +K+ DFG A+ L Sbjct: 121 AAMRILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAADLCG 180 Query: 219 SRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTR 278 S Y APE+I Y + D+WS G V+ + L+G+P F +S D L + + Sbjct: 181 SPMYMAPEVIMS-QHYDAKADLWSIGTVIYQCLVGKPPFQANSPQD-LRMFYEKNRSLMP 238 Query: 279 EQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHS 338 RE +P + + R+ +H Sbjct: 239 SIPRETSPYLANLLLGLL-------------------------QRNQKDRMDFEAFFSHP 273 Query: 339 FFDE 342 F ++ Sbjct: 274 FLEQ 277 >5DYK-A nrPDB Length = 853 Score = 218 bits (556), Expect = 3e-57, Method: Composition-based stats. Identities = 91/391 (23%), Positives = 140/391 (35%), Gaps = 84/391 (21%) Query: 5 PRTTSFAE-----SCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDT 59 PRT S C V + G + + + + Sbjct: 491 PRTASVISKVNNVECWFVDKSVFLQ------IIQGPMLAHLEERIKMQDTKVEMDELETE 544 Query: 60 KVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRF-------KNRELQIMRKLDHCNIVRL 112 ++IG G+FG V + A+K V + E +I + DH I+RL Sbjct: 545 RIIGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLNQQNNIKLEREITAENDHPFIIRL 604 Query: 113 RYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYI 172 F KD Y + + V A R L + Y+ + ++ Y+ Sbjct: 605 VRTF------KDSKYFYFLTELVTGGELYDA---IRKLGLLSKSQAQFYLGSIILAIEYL 655 Query: 173 HSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGAT 232 H I +RD+KP+N+LLD V KL DFG AK++ + + + +Y APE+I G Sbjct: 656 HERNIVYRDLKPENILLDKQGYV-KLIDFGCAKKVQ--GRAYTLVGTPHYMAPEVILG-K 711 Query: 233 DYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFK 292 Y ++D+W+ G L E + G F G+ DQL EI + + T + Sbjct: 712 GYGCTVDIWALGICLYEFICGPLPF-GNDEEDQL-EIFRDILT-------------GQLT 756 Query: 293 FPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTP-----LEACAHSFFDELRDPN 347 FP T ++I L RLL P R+ + H FF Sbjct: 757 FPDY-----------VTDTDSINLMKRLLCRLPQGRIGCSINGFKDIKDHPFF------- 798 Query: 348 VKLPNGRDTPALFNFTTQELSSN---PPLAT 375 NF +L+ PPL + Sbjct: 799 ------------SNFNWDKLAGRLLDPPLVS 817 >4B8L-A nrPDB Length = 286 Score = 218 bits (555), Expect = 4e-57, Method: Composition-based stats. Identities = 77/305 (25%), Positives = 125/305 (40%), Gaps = 51/305 (16%) Query: 46 QGPDRPQ-EVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN-------RE 97 + P R + + +G G FG VY A+ + ++A+K + + + K RE Sbjct: 6 EMPKRKFTIDDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRRE 65 Query: 98 LQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVP-ETVYRVARHYSRAKQTLPVI 156 ++I L H NI+R+ +F+ D + L+L++ P +Y+ + + R Sbjct: 66 IEIQSHLRHPNILRMYNYFH------DRKRIYLMLEFAPRGELYKELQKHGR----FDEQ 115 Query: 157 YVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSY 216 +M +L +L Y H + HRDIKP+NLL+ LK+ DFG + + Sbjct: 116 RSATFMEELADALHYCHERKVIHRDIKPENLLMGYKGE-LKIADFGWSVH-APSLRRRTM 173 Query: 217 ICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTP 276 + Y PE+I G T + +D+W AG + E L+G P F S + I+ V Sbjct: 174 CGTLDYLPPEMIEGKT-HDEKVDLWCAGVLCYEFLVGMPPFDSPSHTETHRRIVNV---- 228 Query: 277 TREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACA 336 + KFP P + L S+LL Y P RL Sbjct: 229 -------------DLKFP------------PFLSDGSKDLISKLLRYHPPQRLPLKGVME 263 Query: 337 HSFFD 341 H + Sbjct: 264 HPWVK 268 >4WNO-A nrPDB Length = 287 Score = 218 bits (555), Expect = 4e-57, Method: Composition-based stats. Identities = 75/313 (23%), Positives = 136/313 (43%), Gaps = 51/313 (16%) Query: 44 PGQGP-DRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGE-LVAIKKVLQ-----DKRFKNR 96 PG+G + + ++ +IG+G+F VV++ + + + VA+K + + + + Sbjct: 7 PGRGGTETVGKFEFSRKDLIGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQTLLGK 66 Query: 97 ELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVI 156 E++I+++L H NIV L F ++ + LV++Y Y A +TL Sbjct: 67 EIKILKELKHENIVALYDF------QEMANSVYLVMEYCNGG---DLADYLHAMRTLSED 117 Query: 157 YVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLL--------DPDTAVLKLCDFGSAKQLV 208 ++L++ Q+ ++ +HS GI HRD+KPQN+LL +P++ +K+ DFG A+ L Sbjct: 118 TIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQ 177 Query: 209 RGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVE 268 + S Y APE+I Y D+WS G ++ + L G+ F S D + Sbjct: 178 SNMMAATLCGSPMYMAPEVIMS-QHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLF 236 Query: 269 IIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTAR 328 E+ + + P P+ + P ++ R Sbjct: 237 ---------YEKNKTLVP-----TIPRETSAPLRQLLLALLQ------------RNHKDR 270 Query: 329 LTPLEACAHSFFD 341 + E H F D Sbjct: 271 MDFDEFFHHPFLD 283 >4FZF-B nrPDB Length = 283 Score = 218 bits (555), Expect = 4e-57, Method: Composition-based stats. Identities = 64/297 (21%), Positives = 111/297 (37%), Gaps = 47/297 (15%) Query: 50 RPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKV-----LQDKRFKNRELQIMRKL 104 P+E+ +T + IG GSFG V++ + ++VAIK + + +E+ ++ + Sbjct: 5 DPEEL-FTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQC 63 Query: 105 DHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQ 164 D + + + + L ++++Y+ + + + Sbjct: 64 DSSYVTKYYGSYLKGSK------LWIIMEYLGGGSALDLLRAG----PFDEFQIATMLKE 113 Query: 165 LFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGE-PNVSYICSRYYR 223 + + L Y+HS HRDIK N+LL V KL FG A QL + +++ + ++ Sbjct: 114 ILKGLDYLHSEKKIHRDIKAANVLLSEQGDV-KLAAFGVAGQLTDTQIKRNTFVGTPFWM 172 Query: 224 APELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIRE 283 APE+I + Y S D+WS G EL G+P + L I + Sbjct: 173 APEVI-QQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLI------------PK 219 Query: 284 MNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF 340 NP F + L P+ R T E H F Sbjct: 220 NNPPTLVGDFTK----------------SFKEFIDACLNKDPSFRPTAKELLKHKFI 260 >4IAN-A nrPDB Length = 358 Score = 217 bits (552), Expect = 8e-57, Method: Composition-based stats. Identities = 87/323 (26%), Positives = 141/323 (43%), Gaps = 54/323 (16%) Query: 63 GNGSFGVVYQAKLCDS-GELVAIKKVLQDKRFKN---RELQIMRKLD--------HCNIV 110 G G F V +A+ + VA+K + ++ + +EL+ ++KL+ HC + Sbjct: 39 GQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTGLKELEFLKKLNDADPDDKFHC--L 96 Query: 111 RLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLA 170 RL FY + +L LV + + + V + Y + L + V+ Y QLF +L Sbjct: 97 RLFRHFYH------KQHLCLVFEPLSMNLREVLKKYGK-DVGLHIKAVRSYSQQLFLALK 149 Query: 171 YIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFG 230 + I H DIKP N+L++ +LKLCDFGSA + + Y+ SR+YRAPE+I G Sbjct: 150 LLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVADND-ITPYLVSRFYRAPEIIIG 208 Query: 231 ATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIRE------- 283 + Y ID+WS GC L EL G+ +FPG + L + + G + IR+ Sbjct: 209 KS-YDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPNKMIRKGVFKDQH 267 Query: 284 --MNPNYTEFKFPQIKAHPWTKVFRPRTPPEA----------------------IALCSR 319 N N+ + ++ V P + L + Sbjct: 268 FDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLADLIGCQRLPEDQRKKVHQLKDLLDQ 327 Query: 320 LLEYTPTARLTPLEACAHSFFDE 342 +L P R++ +A H+F E Sbjct: 328 ILMLDPAKRISINQALQHAFIQE 350 >3ALO-A nrPDB Length = 327 Score = 216 bits (551), Expect = 1e-56, Method: Composition-based stats. Identities = 75/319 (23%), Positives = 128/319 (40%), Gaps = 46/319 (14%) Query: 48 PDRPQEVSYTDTK---VIGNGSFGVVYQAKLCDSGELVAIKKVL-----QDKRFKNRELQ 99 P++ + + D K IG G++G V + SG+++A+K++ ++++ +L Sbjct: 13 PEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLD 72 Query: 100 I-MRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARH-YSRAKQTLPVIY 157 + MR D IV+ + G+ + ++ + + + ++ YS +P Sbjct: 73 VVMRSSDCPYIVQFYGALFREGDC------WICMELMSTSFDKFYKYVYSVLDDVIPEEI 126 Query: 158 VKLYMYQLFRSLAYIHSF-GICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSY 216 + ++L ++ I HRDIKP N+LLD + +KLCDFG + QLV Sbjct: 127 LGKITLATVKALNHLKENLKIIHRDIKPSNILLD-RSGNIKLCDFGISGQLVDSIAKTRD 185 Query: 217 ICSRYYRAPELI---FGATDYTSSIDVWSAGCVLAELLLGQPIFP-GDSGVDQLVEIIKV 272 R Y APE I Y DVWS G L EL G+ +P +S DQL +++K Sbjct: 186 AGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVK- 244 Query: 273 LGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPL 332 G P + + P I + L + R Sbjct: 245 -GDPPQ----------------------LSNSEEREFSPSFINFVNLCLTKDESKRPKYK 281 Query: 333 EACAHSFFDELRDPNVKLP 351 E H F + V++ Sbjct: 282 ELLKHPFILMYEERAVEVA 300 >6GQK-A nrPDB Length = 328 Score = 216 bits (549), Expect = 2e-56, Method: Composition-based stats. Identities = 81/350 (23%), Positives = 125/350 (35%), Gaps = 71/350 (20%) Query: 20 PSAFGSMKVSRDKDGSKVTTVVATPGQGP-DRPQEV---SYTDTKVIGNGSFGVVYQAK- 74 P KV + +G+ + P Q P D E + K +G G+FG V +A Sbjct: 5 PMYEVQWKVVEESNGNNYS--YIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATA 62 Query: 75 ----LCDSGELVAIKKVLQDKRFKNRELQIMRKL-------DHCNIVRLRYFFYSSGEKK 123 D+ VA+K + RE +M +L +H NIV L G Sbjct: 63 QGLIKSDAAMTVAVKMLKPSAHSTEREA-LMSELKVLSYLGNHENIVNLLGACTHGGPTL 121 Query: 124 DEVYLNLVLDYVPETVYRVARHYSR-------------AKQTLPVIYVKLYMYQLFRSLA 170 ++ +Y R K L + ++ + YQ+ + +A Sbjct: 122 ------VITEYCCYGDLLNFLRRKRDEFVPYKVAPEDLYKDFLTLEHLLSFSYQVAKGMA 175 Query: 171 YIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY---YRAPEL 227 ++ S HRD+ +N+LL + K+CDFG A+ + V +R + APE Sbjct: 176 FLASKNCIHRDLAARNILLTH-GNITKICDFGLARDIKNDSNYVDKGNARLPVKWMAPES 234 Query: 228 IFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNP 286 IF + YT DVWS G L EL G +PG + ++IK E R +P Sbjct: 235 IFNSV-YTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIK-------EGFRMSSP 286 Query: 287 NYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACA 336 Y + I W + P R T + Sbjct: 287 EYAPAEMYDIMKTCW--------------------DADPDKRPTFKQIVQ 316 >6CKI-A nrPDB Length = 316 Score = 215 bits (548), Expect = 2e-56, Method: Composition-based stats. Identities = 66/321 (20%), Positives = 124/321 (38%), Gaps = 40/321 (12%) Query: 52 QEVSYTDTK-VIGNGSFGVVYQAKLCDSGELVAIKKVLQD----KRFKNRELQIMRKLD- 105 E Y + V+G G+ V + + A+K + + + RE++++ + Sbjct: 10 FEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQCQG 69 Query: 106 HCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQL 165 H N+ ++E LV + + + ++ + + + + Sbjct: 70 HRNV------LELIEFFEEEDRFYLVFEKMRGGS---ILSHIHKRRHFNELEASVVVQDV 120 Query: 166 FRSLAYIHSFGICHRDIKPQNLLLDPDTAV--LKLCDFGSAKQL--------VRGEPNVS 215 +L ++H+ GI HRD+KP+N+L + V +K+CDFG + + ++ Sbjct: 121 ASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPELLT 180 Query: 216 YICSRYYRAPELIFGATD----YTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIK 271 S Y APE++ ++ Y D+WS G +L LL G P F G G D + Sbjct: 181 PCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDC--GWDR 238 Query: 272 VLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTP 331 P + + + +++FP W + A L S+LL RL+ Sbjct: 239 GEACPACQNMLFESIQEGKYEFPD---KDWAHI-----SCAAKDLISKLLVRDAKQRLSA 290 Query: 332 LEACAHSFFDELRDPNVKLPN 352 + H + P LP Sbjct: 291 AQVLQHPWVQG-CAPENTLPT 310 >1TKI-A nrPDB Length = 321 Score = 215 bits (547), Expect = 3e-56, Method: Composition-based stats. Identities = 65/291 (22%), Positives = 121/291 (41%), Gaps = 38/291 (13%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVL---QDKRFKNRELQIMRKLDHCNIVRL 112 Y + +G G FG+V++ S + K V D+ +E+ I+ H NI+ L Sbjct: 7 YMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGTDQVLVKKEISILNIARHRNILHL 66 Query: 113 RYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYI 172 F S E L ++ +++ + + + L + Y++Q+ +L ++ Sbjct: 67 HESFESMEE------LVMIFEFISG--LDIFERINTSAFELNEREIVSYVHQVCEALQFL 118 Query: 173 HSFGICHRDIKPQNLLLDPD-TAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGA 231 HS I H DI+P+N++ ++ +K+ +FG A+QL G+ + Y APE+ Sbjct: 119 HSHNIGHFDIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLFTAPEYYAPEV-HQH 177 Query: 232 TDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEF 291 +++ D+WS G ++ LL G F ++ + I+ T E +E+ Sbjct: 178 DVVSTATDMWSLGTLVYVLLSGINPFLAETNQQIIENIMNAEYTFDEEAFKEI------- 230 Query: 292 KFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDE 342 EA+ RLL +R+T EA H + + Sbjct: 231 ------------------SIEAMDFVDRLLVKERKSRMTASEALQHPWLKQ 263 >4AF3-A nrPDB Length = 292 Score = 215 bits (547), Expect = 3e-56, Method: Composition-based stats. Identities = 83/311 (26%), Positives = 125/311 (40%), Gaps = 50/311 (16%) Query: 37 VTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN- 95 + TP + + +G G FG VY A+ S +VA+K + + + K Sbjct: 6 MENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEG 65 Query: 96 ------RELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVP-ETVYRVARHYSR 148 RE++I L H NI+RL +FY D + L+L+Y P +Y+ + Sbjct: 66 VEHQLRREIEIQAHLHHPNILRLYNYFY------DRRRIYLILEYAPRGELYKELQKSC- 118 Query: 149 AKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLV 208 T M +L +L Y H + HRDIKP+NL L LK+ DFG + Sbjct: 119 ---TFDEQRTATIMEELADALMYCHGKKVIHRDIKPENL-LLGLKGELKIADFGWSVH-A 173 Query: 209 RGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVE 268 + + Y PE+I G + +D+W G + ELL+G P F S + Sbjct: 174 PSLRRKTMCGTLDYLPPEMIEGRM-HNEKVDLWCIGVLCYELLVGNPPFESASHNETYRR 232 Query: 269 IIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTAR 328 I+KV + KFP P A L S+LL + P+ R Sbjct: 233 IVKV-----------------DLKFP------------ASVPTGAQDLISKLLRHNPSER 263 Query: 329 LTPLEACAHSF 339 L + AH + Sbjct: 264 LPLAQVSAHPW 274 >2VD5-A nrPDB Length = 412 Score = 214 bits (546), Expect = 4e-56, Method: Composition-based stats. Identities = 84/338 (24%), Positives = 128/338 (37%), Gaps = 58/338 (17%) Query: 50 RPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKL----- 104 R Q + KVIG G+F V K+ +G++ A+K + + K E+ R+ Sbjct: 57 RLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLV 116 Query: 105 --DHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYM 162 D I +L + F +DE YL LV++Y + S+ + +P + Y+ Sbjct: 117 NGDRRWITQLHFAF------QDENYLYLVMEYYVGG--DLLTLLSKFGERIPAEMARFYL 168 Query: 163 YQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSY--ICSR 220 ++ ++ +H G HRDIKP N+LLD ++L DFGS +L S + + Sbjct: 169 AEIVMAIDSVHRLGYVHRDIKPDNILLD-RCGHIRLADFGSCLKLRADGTVRSLVAVGTP 227 Query: 221 YYRAPELIFG------ATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLG 274 Y +PE++ Y D W+ G E+ GQ F DS + +I+ Sbjct: 228 DYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIV---- 283 Query: 275 TPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARL---TP 331 K H + P EA RLL P RL Sbjct: 284 --------------------HYKEHLSLPLVDEGVPEEARDFIQRLLCP-PETRLGRGGA 322 Query: 332 LEACAHSFF-----DELRDPNVKL-PNGRDTPALFNFT 363 + H FF D LRD P+ NF Sbjct: 323 GDFRTHPFFFGLDWDGLRDSVPPFTPDFEGATDTCNFD 360 >2WQN-A nrPDB Length = 310 Score = 214 bits (544), Expect = 7e-56, Method: Composition-based stats. Identities = 71/286 (24%), Positives = 119/286 (41%), Gaps = 42/286 (14%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVL-------QDKRFKNRELQIMRKLDHC 107 ++ K IG G F VY+A G VA+KKV + + +E+ ++++L+H Sbjct: 33 NFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHP 92 Query: 108 NIVRLRYFFYSSGEKKDEVYLNLVLDYVP-ETVYRVARHYSRAKQTLPVIYVKLYMYQLF 166 N+++ F E LN+VL+ + R+ +H+ + K+ +P V Y QL Sbjct: 93 NVIKYYASFIEDNE------LNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLC 146 Query: 167 RSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQL-VRGEPNVSYICSRYYRAP 225 +L ++HS + HRDIKP N+ + T V+KL D G + + S + + YY +P Sbjct: 147 SALEHMHSRRVMHRDIKPANVFITA-TGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSP 205 Query: 226 ELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMN 285 E I Y D+WS GC+L E+ Q F GD + + + Sbjct: 206 ERIH-ENGYNFKSDIWSLGCLLYEMAALQSPFYGD-----------------KMNLYSLC 247 Query: 286 PNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTP 331 + +P + E L + + P R Sbjct: 248 KKIEQCDYPPLP--------SDHYSEELRQLVNMCINPDPEKRPDV 285 >5FET-A nrPDB Length = 847 Score = 213 bits (543), Expect = 1e-55, Method: Composition-based stats. Identities = 91/387 (23%), Positives = 142/387 (36%), Gaps = 76/387 (19%) Query: 5 PRTTSFAESCKPVQQPSAFGSMKV-SRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIG 63 PRT S K F V + G +T + + + ++IG Sbjct: 485 PRTASIIS--KATSVECWFVDKSVFLQIIQGPMLTHLEERIKMQDTKVEMHELETERIIG 542 Query: 64 NGSFGVVYQAKLCDSGELVAIKKVLQDKRF-------KNRELQIMRKLDHCNIVRLRYFF 116 G+FG V + A+K V + E +I + DH I+RL F Sbjct: 543 RGTFGTVKLVHHKPTQIRYALKCVSKRSIISLNQQNNIKLEREITAENDHPFIIRLVRTF 602 Query: 117 YSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFG 176 KD + + V A R L + Y+ + ++ Y+H Sbjct: 603 ------KDSNCFYFLTELVTGGELYDA---IRKLGLLSKPQAQFYLGSIILAIEYLHERN 653 Query: 177 ICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTS 236 I +RD+KP+N+LLD V KL DFG AK++ + + + +Y APE+I G Y Sbjct: 654 IVYRDLKPENILLDKQGYV-KLIDFGCAKKIQ--GRAYTLVGTPHYMAPEVILG-KGYGC 709 Query: 237 SIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQI 296 ++D+W+ G L E + G F G+ DQL EI + + T + FP Sbjct: 710 TVDIWALGVCLYEFICGPLPF-GNDQEDQL-EIFRDILT-------------GQLTFPDY 754 Query: 297 KAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTP-----LEACAHSFFDELRDPNVKLP 351 + ++I L RLL P R+ + H+FF Sbjct: 755 -----------VSDQDSINLMKRLLCRLPQGRIGCSINGFKDIKEHAFFG---------- 793 Query: 352 NGRDTPALFNFTTQELSS---NPPLAT 375 NF +L+ PPL + Sbjct: 794 ---------NFNWDKLAGRLLEPPLVS 811 >3G0E-A nrPDB Length = 336 Score = 213 bits (543), Expect = 1e-55, Method: Composition-based stats. Identities = 80/343 (23%), Positives = 129/343 (37%), Gaps = 58/343 (16%) Query: 15 KPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGP-DRPQEV---SYTDTKVIGNGSFGVV 70 K +Q+P KV + +G+ V P Q P D E + K +G G+FG V Sbjct: 5 KYLQKPMYEVQWKVVEEINGNNY--VYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKV 62 Query: 71 YQAK-----LCDSGELVAIKKVLQDKRFKNRELQIMRKL-------DHCNIVRLRYFFYS 118 +A D+ VA+K + RE +M +L +H NIV L Sbjct: 63 VEATAYGLIKSDAAMTVAVKMLKPSAHLTEREA-LMSELKVLSYLGNHMNIVNLLGACTI 121 Query: 119 SGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTL-----------------PVIYVKLY 161 G ++ +Y + R + + + + + Sbjct: 122 GGPTL------VITEYCCYG--DLLNFLRRKRDSFICSKTSPAIMEDDELALDLEDLLSF 173 Query: 162 MYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY 221 YQ+ + +A++ S HRD+ +N+LL + K+CDFG A+ + V +R Sbjct: 174 SYQVAKGMAFLASKNCIHRDLAARNILLTH-GRITKICDFGLARDIKNDSNYVVKGNARL 232 Query: 222 ---YRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPT 277 + APE IF YT DVWS G L EL G +PG + ++IK Sbjct: 233 PVKWMAPESIFNCV-YTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIK------ 285 Query: 278 REQIREMNPNYTEFKFPQIKAHPWTKVFRPRTP-PEAIALCSR 319 E R ++P + + I W R + + L + Sbjct: 286 -EGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEK 327 >4C0T-A nrPDB Length = 974 Score = 212 bits (541), Expect = 2e-55, Method: Composition-based stats. Identities = 79/366 (21%), Positives = 145/366 (39%), Gaps = 63/366 (17%) Query: 31 DKDGSKVTTVVATPGQGPDRPQEVS-YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ 89 +K G+ V T+ G+ + V+ + K +G GS+ V A +G+ A+K + + Sbjct: 242 EKKGAAVKTIKTMDGEMKTIRRNVTDFKFGKELGEGSYSTVILATDKITGKQYAVKVLDK 301 Query: 90 DKRFKNR-------ELQIMRKLDHC-NIVRLRYFFYSSGEKKDEVYLNLVLDYVPET-VY 140 K + E + +L + ++ L + F +D+ L VLDY + Sbjct: 302 RHIIKEKKVKYVNIEKHALNRLSNRLGVISLYFTF------QDKDSLYFVLDYASNGELL 355 Query: 141 RVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCD 200 + + Y TL + + Q+ ++ Y+H G+ HRD+KP+N+LLD D +++ D Sbjct: 356 TLIKRY----NTLNEECTRHFGAQILDAIKYMHDNGVIHRDLKPENILLD-DKMRIQITD 410 Query: 201 FGSAKQLVR----------GEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAEL 250 FG+A+ L + S++ + Y +PEL+ DVW+ GC++ ++ Sbjct: 411 FGTARLLEKKNDESEEYPVDVRAKSFVGTAEYVSPELLEN-KYCGKPGDVWAFGCIIYQM 469 Query: 251 LLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTP 310 + G+P F + +I K+ F P Sbjct: 470 IAGKPPFKATNEYLTFQKITKL-----------------------------QFAFSAGFP 500 Query: 311 PEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPAL--FNFTTQELS 368 L ++L P+ R T E H FF + + D P + + T + + Sbjct: 501 TIIRDLIKKILVLQPSRRATIPEIQKHYFFQSVDFKDFDSIWLSDPPEIGPYKMTAKSMM 560 Query: 369 SNPPLA 374 P L Sbjct: 561 KVPELN 566 >3A8W-A nrPDB Length = 345 Score = 212 bits (540), Expect = 2e-55, Method: Composition-based stats. Identities = 77/352 (21%), Positives = 138/352 (39%), Gaps = 70/352 (19%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ-------DKRFKNRELQIMRKL-DH 106 + +VIG GS+ V +L + + A+K V + D + E + + +H Sbjct: 10 DFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNH 69 Query: 107 CNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLF 166 +V L F + E L V++YV + + ++ LP + + Y ++ Sbjct: 70 PFLVGLHSCF------QTESRLFFVIEYVNGG---DLMFHMQRQRKLPEEHARFYSAEIS 120 Query: 167 RSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ-LVRGEPNVSYICSRYYRAP 225 +L Y+H GI +RD+K N+LLD + +KL D+G K+ L G+ ++ + Y AP Sbjct: 121 LALNYLHERGIIYRDLKLDNVLLDSEGH-IKLTDYGMCKEGLRPGDTTSTFCGTPNYIAP 179 Query: 226 ELIFGATDYTSSIDVWSAGCVLAELLLGQPIF--------PGDSGVDQLVEIIKVLGTPT 277 E++ G DY S+D W+ G ++ E++ G+ F P + D L ++I Sbjct: 180 EILRG-EDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVI------- 231 Query: 278 REQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTP------ 331 + + P+ +A ++ L P RL Sbjct: 232 ---------LEKQIRIPR------------SLSVKAASVLKSFLNKDPKERLGCHPQTGF 270 Query: 332 LEACAHSFFDELRDPNVK--------LPNGRDTPALFNFTTQELSSNPPLAT 375 + H FF + ++ PN L NF +Q + L Sbjct: 271 ADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTP 322 >4GS6-A nrPDB Length = 315 Score = 211 bits (538), Expect = 4e-55, Method: Composition-based stats. Identities = 74/288 (25%), Positives = 125/288 (43%), Gaps = 29/288 (10%) Query: 57 TDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN--RELQIMRKLDHCNIVRLRY 114 +V+G G+FGVV +AK + VAIK++ + K EL+ + +++H NIV+L Sbjct: 12 EVEEVVGRGAFGVVCKAKWRA--KDVAIKQIESESERKAFIVELRQLSRVNHPNIVKLYG 69 Query: 115 FFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHS 174 + + LV++Y H + + + Q + +AY+HS Sbjct: 70 ACLNP--------VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHS 121 Query: 175 FG---ICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGA 231 + HRD+KP NLLL VLK+CDFG+A + + S + APE+ G+ Sbjct: 122 MQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQ--THMTNNKGSAAWMAPEVFEGS 179 Query: 232 TDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEF 291 +Y+ DV+S G +L E++ + F D I+ + TR + + P E Sbjct: 180 -NYSEKCDVFSWGIILWEVITRRKPF--DEIGGPAFRIMWAVHNGTRPPLIKNLPKPIE- 235 Query: 292 KFPQIKAHPWTKVFRPRTP-PEAIALCSRLLEYTPTARLTPLEACAHS 338 + W+K R E + + + L+ Y P E + Sbjct: 236 ---SLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPG----ADEPLQYP 276 >4OLI-A nrPDB Length = 645 Score = 211 bits (537), Expect = 4e-55, Method: Composition-based stats. Identities = 82/361 (22%), Positives = 140/361 (38%), Gaps = 45/361 (12%) Query: 5 PRTTSFAESC---KPVQQPSAFGSMKVSRDKDGSKVTTVVA----TPGQGPDRPQEVSYT 57 P+ + C +P Q+PS ++ + V+ +P P + Sbjct: 297 PQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLK 356 Query: 58 DTKVIGNGSFGVV----YQAKLCDSGELVAIKKVLQDKRFKNR-----ELQIMRKLDHCN 108 + +G G FG V Y +GE+VA+K + D ++R E+ I+R L H + Sbjct: 357 KIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEH 416 Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRS 168 I++ + GEK L LV++YVP R + ++ + + L+ Q+ Sbjct: 417 IIKYKGCCEDQGEKS----LQLVMEYVPLGSLRDYL----PRHSIGLAQLLLFAQQICEG 468 Query: 169 LAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYI----CSRYYRA 224 +AY+HS HR++ +N+LLD D V K+ DFG AK + G ++ A Sbjct: 469 MAYLHSQHYIHRNLAARNVLLDNDRLV-KIGDFGLAKAVPEGHEYYRVREDGDSPVFWYA 527 Query: 225 PELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREM 284 PE + Y + DVWS G L ELL DS + ++++G + Sbjct: 528 PECLKEYKFY-YASDVWSFGVTLYELLT-----HCDSSQSPPTKFLELIGIAQGQM---- 577 Query: 285 NPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELR 344 T + ++ + P E L E + R T + Sbjct: 578 ----TVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLI--PILKTVH 631 Query: 345 D 345 + Sbjct: 632 E 632 Score = 94.7 bits (234), Expect = 6e-20, Method: Composition-based stats. Identities = 49/276 (17%), Positives = 92/276 (33%), Gaps = 53/276 (19%) Query: 73 AKLCDSGELVAIKKVLQDKRFKN----RELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYL 128 + V +K + +M ++ H ++ + E Sbjct: 88 GRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPEN------ 141 Query: 129 NLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLL 188 +V +YV V R + +P+ + + QL +L+Y+ + + H ++ +N+L Sbjct: 142 IMVTEYVEHGPLDV--WLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNIL 199 Query: 189 L------DPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELI-FGATDYTSSIDVW 241 L + + +KL D G + E V I + APE + GA ++++D W Sbjct: 200 LARLGLAEGTSPFIKLSDPGVGLGALSREERVERI---PWLAPECLPGGANSLSTAMDKW 256 Query: 242 SAGCVLAEL-LLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP 300 G L E+ G+ S + +E + E PQ+ Sbjct: 257 GFGATLLEICFDGEAPLQSRSPSE-------------KEHFYQRQHRLPEPSCPQLAT-- 301 Query: 301 WTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACA 336 L S+ L Y PT R + Sbjct: 302 ---------------LTSQCLTYEPTQRPSFRTILR 322 >3LM0-A nrPDB Length = 327 Score = 211 bits (537), Expect = 5e-55, Method: Composition-based stats. Identities = 63/308 (20%), Positives = 117/308 (37%), Gaps = 42/308 (13%) Query: 60 KVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN------RELQIMRKLDH-CNIVRL 112 K +G G F VV Q +G+ A K + + +R ++ E+ ++ ++ L Sbjct: 35 KELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELAKSCPRVINL 94 Query: 113 RYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYI 172 + ++ E + L+L+Y + + + V + Q+ + Y+ Sbjct: 95 HEVYENTSE------IILILEYAAGG-EIFSLCLPELAEMVSENDVIRLIKQILEGVYYL 147 Query: 173 HSFGICHRDIKPQNLLLDP--DTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFG 230 H I H D+KPQN+LL +K+ DFG ++++ + + Y APE I Sbjct: 148 HQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACELREIMGTPEYLAPE-ILN 206 Query: 231 ATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTE 290 T++ D+W+ G + LL F G+ + + I +V N +Y+E Sbjct: 207 YDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQV------------NVDYSE 254 Query: 291 FKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKL 350 F + A LL P R T +HS+ + N+ Sbjct: 255 ETFSSV-------------SQLATDFIQSLLVKNPEKRPTAEICLSHSWLQQWDFENLFH 301 Query: 351 PNGRDTPA 358 P + + Sbjct: 302 PEETSSSS 309 >3QA8-A nrPDB Length = 676 Score = 210 bits (535), Expect = 8e-55, Method: Composition-based stats. Identities = 79/298 (26%), Positives = 126/298 (42%), Gaps = 15/298 (5%) Query: 45 GQGPDRPQEVS--YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRE----- 97 G+ P P + + + +G G FG V + D+GE VAIK+ Q+ KNRE Sbjct: 3 GRSPSLPTQTCGPWEMKERLGTGGFGYVLRWIHQDTGEQVAIKQCRQELSPKNRERWCLE 62 Query: 98 LQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIY 157 +QIM+KL+H N+V R + L ++Y R + L Sbjct: 63 IQIMKKLNHPNVVSAREVPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGP 122 Query: 158 VKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVL--KLCDFGSAKQLVRGEPNVS 215 ++ + + +L Y+H I HRD+KP+N++L P L K+ D G AK+L +GE Sbjct: 123 IRTLLSDISSALRYLHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQGELCTE 182 Query: 216 YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGT 275 ++ + Y APEL+ YT ++D WS G + E + G F + Q V+ + Sbjct: 183 FVGTLQYLAPELLEQ-KKYTVTVDYWSFGTLAFECITGFRPFLPN---WQPVQWHGKVRE 238 Query: 276 PTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLE 333 + E I + KF + P E +L + R T + Sbjct: 239 KSNEHIVVYDDLTGAVKFSSVLPTPNHLSGILAGKLERW--LQCMLMWHQRQRGTDPQ 294 >4YHJ-A nrPDB Length = 584 Score = 210 bits (534), Expect = 1e-54, Method: Composition-based stats. Identities = 72/351 (20%), Positives = 132/351 (37%), Gaps = 48/351 (13%) Query: 5 PRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGN 64 P +F E C V + ++ S + + + ++ +V+G Sbjct: 138 PSKKAF-EECTRVAH-NYLRGEPFEEYQESSYFSQFLQWKWLERQPVTKNTFRHYRVLGK 195 Query: 65 GSFGVVYQAKLCDSGELVAI-------KKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFY 117 G FG V ++ +G++ A K + + E +I+ K+ +V L Y + Sbjct: 196 GGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSRFVVSLAYAY- 254 Query: 118 SSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGI 177 E KD + L L + + + + Y+ Y +L L + I Sbjct: 255 ---ETKDALCLVLTIMNGGDLKFHI---YNLGNPGFDEQRAVFYAAELCCGLEDLQRERI 308 Query: 178 CHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSS 237 +RD+KP+N+LLD D +++ D G A ++ G+ + + Y APE++ YT S Sbjct: 309 VYRDLKPENILLD-DRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVV-NNEKYTFS 366 Query: 238 IDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIK 297 D W GC++ E++ G F KV ++I+ Y+E Sbjct: 367 PDWWGLGCLIYEMIQGHSPFK--------KYKEKVKWEEVDQRIKNDTEEYSE------- 411 Query: 298 AHPWTKVFRPRTPPEAIALCSRLLEYTPTARL-----TPLEACAHSFFDEL 343 + +A ++C LL P+ RL H F ++ Sbjct: 412 ----------KFSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDI 452 >6BDL-A nrPDB Length = 347 Score = 209 bits (533), Expect = 2e-54, Method: Composition-based stats. Identities = 83/366 (22%), Positives = 138/366 (37%), Gaps = 69/366 (18%) Query: 52 QEVSYTDTKVIGNGSFGVVYQAKLC-DSGELVAIKKVLQ-------DKRFKNRELQIMRK 103 + + +G G FG V +L + + A+K + + + E QIM+ Sbjct: 32 KLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQG 91 Query: 104 LDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMY 163 IVRL F KD YL ++++ R + + + Y Sbjct: 92 AHSDFIVRLYRTF------KDSKYLYMLMEACLGGELWTIL---RDRGSFEDSTTRFYTA 142 Query: 164 QLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYR 223 + + AY+HS GI +RD+KP+NL+LD KL DFG AK++ G+ ++ + Y Sbjct: 143 CVVEAFAYLHSKGIIYRDLKPENLILDHRGYA-KLVDFGFAKKIGFGKKTWTFCGTPEYV 201 Query: 224 APELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIRE 283 APE+I + S D WS G ++ ELL G P F G + I++ + Sbjct: 202 APEIILN-KGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDM-------- 252 Query: 284 MNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARL-----TPLEACAHS 338 +FP+ + A L +L P+ RL + H Sbjct: 253 -------IEFPK------------KIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHK 293 Query: 339 FFDELRDPNVKLPNGRDTPALFNFTT-QELSSNPPLATILIPPHARIQAAASPPANATAA 397 +F+ FN+ ++ + PP+ + P + P N Sbjct: 294 WFEG-----------------FNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNDEPP 336 Query: 398 SDTNAG 403 D N+G Sbjct: 337 PDDNSG 342 >4FR4-A nrPDB Length = 384 Score = 209 bits (532), Expect = 2e-54, Method: Composition-based stats. Identities = 73/300 (24%), Positives = 128/300 (42%), Gaps = 46/300 (15%) Query: 54 VSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN-------RELQIMRKLDH 106 + + IG GSFG V + D+ ++ A+K + + K + +ELQIM+ L+H Sbjct: 15 DHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQGLEH 74 Query: 107 CNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLF 166 +V L Y F +DE + +V+D + R++ + VKL++ +L Sbjct: 75 PFLVNLWYSF------QDEEDMFMVVDLLLGG---DLRYHLQQNVHFKEETVKLFICELV 125 Query: 167 RSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPE 226 +L Y+ + I HRD+KP N+LLD V + DF A L R + ++ Y APE Sbjct: 126 MALDYLQNQRIIHRDMKPDNILLDEHGHV-HITDFNIAAMLPRETQITTMAGTKPYMAPE 184 Query: 227 LIFGAT--DYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREM 284 + Y+ ++D WS G ELL G+ + + + T + Sbjct: 185 MFSSRKGAGYSFAVDWWSLGVTAYELLRGRRPYH--------------IRSSTSSKEIVH 230 Query: 285 NPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLT-PLEACAHSFFDEL 343 T +P W++ E ++L +LLE P R + + + +++ Sbjct: 231 TFETTVVTYPS----AWSQ--------EMVSLLKKLLEPNPDQRFSQLSDVQNFPYMNDI 278 >6CQF-A nrPDB Length = 297 Score = 209 bits (532), Expect = 2e-54, Method: Composition-based stats. Identities = 64/291 (21%), Positives = 116/291 (39%), Gaps = 41/291 (14%) Query: 54 VSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ----DKRFKNRELQIMRKLDHCNI 109 Y + +G G++G V++A+ SG+LVA+K V D +E+ I++ H NI Sbjct: 16 DHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRHANI 75 Query: 110 VRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 169 V + + L + +++ + + +L + + ++ + L Sbjct: 76 VAYHGSYLWLQK------LWICMEFCGAGSLQDIYQVT---GSLSELQISYVCREVLQGL 126 Query: 170 AYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRG-EPNVSYICSRYYRAPEL- 227 AY+HS HRDIK N+L++ D ++L DFG + Q+ +++I + Y+ APE+ Sbjct: 127 AYLHSQKKIHRDIKGANILIN-DAGEVRLADFGISAQIGATLARRLAFIGTPYWMAPEVA 185 Query: 228 -IFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNP 286 + Y D+WS G EL QP + L + K P R + Sbjct: 186 AVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLK------ 239 Query: 287 NYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAH 337 + W+ F L +P R + + +H Sbjct: 240 ----------EKGKWSAAFH--------NFIKVTLTKSPKKRPSATKMLSH 272 >4APC-A nrPDB Length = 350 Score = 207 bits (528), Expect = 6e-54, Method: Composition-based stats. Identities = 79/346 (22%), Positives = 130/346 (37%), Gaps = 50/346 (14%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVL------QDKRFKNRELQIMRKLDHCNI 109 Y + IG GSFG K + G IK++ +++ RE+ ++ + H NI Sbjct: 26 YVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKHPNI 85 Query: 110 VRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 169 V+ R F +G L +V+DY R ++ + + Q+ +L Sbjct: 86 VQYRESFEENGS------LYIVMDYCEGGDL-FKRINAQKGVLFQEDQILDWFVQICLAL 138 Query: 170 AYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYI-CSRYYRAPELI 228 ++H I HRDIK QN+ L D V +L DFG A+ L + YY +PE I Sbjct: 139 KHVHDRKILHRDIKSQNIFLTKDGTV-QLGDFGIARVLNSTVELARACIGTPYYLSPE-I 196 Query: 229 FGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNY 288 Y + D+W+ GCVL EL + F S + +++II Sbjct: 197 CENKPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIIS----------------- 239 Query: 289 TEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRD--- 345 FP + H + +L S+L + P R + F + + Sbjct: 240 --GSFPPVSLH---------YSYDLRSLVSQLFKRNPRDRPSVNSILEKGFIAKRIEKFL 288 Query: 346 PNVKLPNGRDTPALFNFTTQELSSNPPL---ATILIPPHARIQAAA 388 + F +Q + + P +I + P +I A Sbjct: 289 SPQLIAEEFCLKTFSKFGSQPIPAKRPASGQNSISVMPAQKITKPA 334 >4CRS-A nrPDB Length = 341 Score = 207 bits (527), Expect = 7e-54, Method: Composition-based stats. Identities = 84/351 (23%), Positives = 136/351 (38%), Gaps = 69/351 (19%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIM----------RKL 104 + V+ G FG V A+ ++ E+ AIK + + E+ + + Sbjct: 13 DFRCCAVLLRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSV 72 Query: 105 DHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQ 164 H +V L F + + ++ V++Y + H Y Sbjct: 73 RHPFLVNLFACF------QTKEHVCFVMEYAAGGDLMMHIHT----DVFSEPRAVFYAAC 122 Query: 165 LFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ-LVRGEPNVSYICSRYYR 223 + L Y+H I +RD+K NLLLD + V K+ DFG K+ + G+ ++ + + Sbjct: 123 VVLGLQYLHEHKIVYRDLKLDNLLLDTEGFV-KIADFGLCKEGMGYGDRTSTFCGTPEFL 181 Query: 224 APELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIRE 283 APE++ T YT ++D W G ++ E+L+G+ FPGD + I+ Sbjct: 182 APEVLT-ETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVN------------ 228 Query: 284 MNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARL-----TPLEACAHS 338 E ++P+ EAI++ RLL P RL + H Sbjct: 229 -----DEVRYPRF------------LSTEAISIMRRLLRRNPERRLGASEKDAEDVKKHP 271 Query: 339 FF-----DELRDPNVK---LPNGRDTPALFNFTTQELSSNPPLATILIPPH 381 FF L D VK +P R + NF E +S P IL PP Sbjct: 272 FFRLIDWSALMDKKVKPPFIPTIRGREDVSNF-DDEFTSEAP---ILTPPR 318 >5TQX-A nrPDB Length = 655 Score = 207 bits (527), Expect = 7e-54, Method: Composition-based stats. Identities = 69/280 (24%), Positives = 112/280 (40%), Gaps = 14/280 (5%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRE-----LQIMRKLDHCNIV 110 + + +G G FG V + + +AIK + KNRE +QIM+KL+H N+V Sbjct: 10 WEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCHEIQIMKKLNHANVV 69 Query: 111 RLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLA 170 + +V L L ++Y R + L + + + + Sbjct: 70 KACDVPEELNILIHDVPL-LAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSGIR 128 Query: 171 YIHSFGICHRDIKPQNLLLDPDTAVL--KLCDFGSAKQLVRGEPNVSYICSRYYRAPELI 228 Y+H I HRD+KP+N++L + K+ D G AK + +GE ++ + Y APE + Sbjct: 129 YLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGELCTEFVGTLQYLAPE-L 187 Query: 229 FGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNY 288 F YT+++D WS G ++ E + G F E IK I Sbjct: 188 FENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPKC---IFACEEMS 244 Query: 289 TEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTAR 328 E +F P + P E +L + P R Sbjct: 245 GEVRFSSHLPQPNSLCSLIVEPMENW--LQLMLNWDPQQR 282 >6DBN-A nrPDB Length = 316 Score = 207 bits (527), Expect = 8e-54, Method: Composition-based stats. Identities = 66/316 (20%), Positives = 128/316 (40%), Gaps = 38/316 (12%) Query: 30 RDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLC----DSGELVAIK 85 +++ V+ P ++ + +G G FG V + ++GE VA+K Sbjct: 11 EEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVK 70 Query: 86 KVLQDK-----RFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVY 140 + + +E++I+R L H NIV+ + G + L+++++P Sbjct: 71 SLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNG----IKLIMEFLPSGSL 126 Query: 141 RVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCD 200 + + + K + + Y Q+ + + Y+ S HRD+ +N+L++ + +K+ D Sbjct: 127 K--EYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESE-HQVKIGD 183 Query: 201 FGSAKQLVRGEPNVSYICSR----YYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPI 256 FG K + + + R ++ APE + + Y + DVWS G L ELL Sbjct: 184 FGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFY-IASDVWSFGVTLHELLT---- 238 Query: 257 FPGDSGVDQLVEIIKVLGTPTREQ--IREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAI 314 DS + +K++G + R +N + P P P E Sbjct: 239 -YCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLP----------CPPNCPDEVY 287 Query: 315 ALCSRLLEYTPTARLT 330 L + E+ P+ R + Sbjct: 288 QLMRKCWEFQPSNRTS 303 >4PWN-A nrPDB Length = 274 Score = 207 bits (526), Expect = 9e-54, Method: Composition-based stats. Identities = 58/289 (20%), Positives = 109/289 (37%), Gaps = 41/289 (14%) Query: 62 IGNGSFGVVYQAKLCDSGELVAI------KKVLQDKRFKNRELQIMRKLDHCNIVRLRYF 115 IG GSF VY+ ++ VA K +++ E ++++ L H NIVR Sbjct: 18 IGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQHPNIVRFYDS 77 Query: 116 FYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSF 175 + S+ K + + LV + + + Y + + + + ++ + Q+ + L ++H+ Sbjct: 78 WEST--VKGKKCIVLVTELMTSGT---LKTYLKRFKVMKIKVLRSWCRQILKGLQFLHTR 132 Query: 176 G--ICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATD 233 I HRD+K N+ + T +K+ D G A R S I + + APE+ Sbjct: 133 TPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLEKRASFAKSVIGTPEFMAPEMY--EEK 190 Query: 234 YTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKF 293 Y S+DV++ G + E+ + + Q+ + P Sbjct: 191 YDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPAS--------------- 235 Query: 294 PQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDE 342 F PE + + R + + H+FF E Sbjct: 236 -----------FDKVAIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQE 273 >2BRG-A nrPDB Length = 297 Score = 206 bits (525), Expect = 1e-53, Method: Composition-based stats. Identities = 76/300 (25%), Positives = 124/300 (41%), Gaps = 44/300 (14%) Query: 51 PQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDK-----RFKNRELQIMRKLD 105 P + + +G G++G V A + E VA+K V + +E+ I + L+ Sbjct: 4 PFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLN 63 Query: 106 HCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQL 165 H N+V+ FY + + YL L E R+ +P + + +QL Sbjct: 64 HENVVK----FYGHRREGNIQYLFLEYCSGGELFDRI-----EPDIGMPEPDAQRFFHQL 114 Query: 166 FRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNV---SYICSRYY 222 + Y+H GI HRDIKP+NLLLD LK+ DFG A + Y Sbjct: 115 MAGVVYLHGIGITHRDIKPENLLLDERDN-LKISDFGLATVFRYNNRERLLNKMCGTLPY 173 Query: 223 RAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIR 282 APEL+ + +DVWS G VL +L G+ + S Q Sbjct: 174 VAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQ----------------- 216 Query: 283 EMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDE 342 Y+++K + +PW K+ +AL ++L P+AR+T + ++++ Sbjct: 217 ----EYSDWKEKKTYLNPWKKIDSAP-----LALLHKILVENPSARITIPDIKKDRWYNK 267 >3VN9-A nrPDB Length = 340 Score = 206 bits (525), Expect = 1e-53, Method: Composition-based stats. Identities = 63/299 (21%), Positives = 122/299 (40%), Gaps = 43/299 (14%) Query: 52 QEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVL-----QDKRFKNRELQI-MRKLD 105 + +G G++GVV + + SG+++A+K++ Q+++ +L I MR +D Sbjct: 49 KADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVD 108 Query: 106 HCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQL 165 V + G+ + + ++ + ++ + + QT+P + + Sbjct: 109 CPFTVTFYGALFREGD------VWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSI 162 Query: 166 FRSLAYIHSF-GICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRA 224 ++L ++HS + HRD+KP N+L++ +K+CDFG + LV + Y A Sbjct: 163 VKALEHLHSKLSVIHRDVKPSNVLINA-LGQVKMCDFGISGYLVDSVAKTIDAGCKPYMA 221 Query: 225 PELI---FGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQI 281 PE I Y+ D+WS G + EL + + + GTP ++ Sbjct: 222 PERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDS-------------WGTPFQQ-- 266 Query: 282 REMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF 340 Q+ P ++ + E + S+ L+ R T E H FF Sbjct: 267 -----------LKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFF 314 >3FME-A nrPDB Length = 290 Score = 206 bits (524), Expect = 2e-53, Method: Composition-based stats. Identities = 63/299 (21%), Positives = 122/299 (40%), Gaps = 43/299 (14%) Query: 52 QEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVL-----QDKRFKNRELQI-MRKLD 105 + +G G++GVV + + SG+++A+K++ Q+++ +L I MR +D Sbjct: 5 KADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVD 64 Query: 106 HCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQL 165 V + G+ + + ++ + ++ + + QT+P + + Sbjct: 65 CPFTVTFYGALFREGD------VWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSI 118 Query: 166 FRSLAYIHSF-GICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRA 224 ++L ++HS + HRD+KP N+L++ +K+CDFG + LV + Y A Sbjct: 119 VKALEHLHSKLSVIHRDVKPSNVLINA-LGQVKMCDFGISGYLVDDVAKDIDAGCKPYMA 177 Query: 225 PELI---FGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQI 281 PE I Y+ D+WS G + EL + + + GTP ++ Sbjct: 178 PERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDS-------------WGTPFQQ-- 222 Query: 282 REMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF 340 Q+ P ++ + E + S+ L+ R T E H FF Sbjct: 223 -----------LKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFF 270 >6GVJ-A nrPDB Length = 429 Score = 206 bits (524), Expect = 2e-53, Method: Composition-based stats. Identities = 81/373 (21%), Positives = 142/373 (38%), Gaps = 64/373 (17%) Query: 10 FAESCK---PVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVS-YTDTKVIGNG 65 F +C+ P QP+ F + + V+A+ + Y+ K IG+G Sbjct: 96 FPPACQLSTPYGQPACFQQQQHQILATPLQNLQVLASSSANECISVKGRIYSILKQIGSG 155 Query: 66 SFGVVYQAKLCDSGELVAIKKVLQDKRFKN------RELQIMRKLDHCN--IVRLRYFFY 117 V+Q L + ++ AIK V ++ E+ + KL + I+RL + Sbjct: 156 GSSKVFQV-LNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDY-- 212 Query: 118 SSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGI 177 + + Y+ +V++ + + + K+++ K Y + ++ IH GI Sbjct: 213 ----EITDQYIYMVMECGNIDL----NSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGI 264 Query: 178 CHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNV---SYICSRYYRAPELIFG---- 230 H D+KP N L+ +LKL DFG A Q+ +V S + + Y PE I Sbjct: 265 VHSDLKPANFLIV--DGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSS 322 Query: 231 ------ATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREM 284 + + DVWS GC+L + G+ F Q++ I L + Sbjct: 323 RENGKSKSKISPKSDVWSLGCILYYMTYGKTPF------QQIINQISKLHAI-------I 369 Query: 285 NPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELR 344 +PN+ E +FP I + L+ P R++ E AH + Sbjct: 370 DPNH-EIEFPDIPEKDLQ------------DVLKCCLKRDPKQRISIPELLAHPYVQIQT 416 Query: 345 DPNVKLPNGRDTP 357 P ++ G Sbjct: 417 HPVNQMAKGTTEE 429 >3C51-A nrPDB Length = 543 Score = 206 bits (523), Expect = 2e-53, Method: Composition-based stats. Identities = 72/310 (23%), Positives = 127/310 (40%), Gaps = 45/310 (14%) Query: 53 EVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNR-------ELQIMRKLD 105 E + D +V+G G FG V+ ++ +G+L A KK+ + + K + E +I+ K+ Sbjct: 184 EDWFLDFRVLGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILAKVH 243 Query: 106 HCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQL 165 IV L Y F E K ++ L + + + Y + + Y Q+ Sbjct: 244 SRFIVSLAYAF----ETKTDLCLVMTIMNGGDIRYHIY-NVDEDNPGFQEPRAIFYTAQI 298 Query: 166 FRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNV-SYICSRYYRA 224 L ++H I +RD+KP+N+LLD D V ++ D G A +L G+ Y + + A Sbjct: 299 VSGLEHLHQRNIIYRDLKPENVLLDDDGNV-RISDLGLAVELKAGQTKTKGYAGTPGFMA 357 Query: 225 PELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREM 284 PEL+ G Y S+D ++ G L E++ + F KV ++++ E Sbjct: 358 PELLLGEE-YDFSVDYFALGVTLYEMIAARGPFRARGE--------KVENKELKQRVLEQ 408 Query: 285 NPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARL-----TPLEACAHSF 339 Y + + P + C LL+ P RL + H Sbjct: 409 AVTYPD-----------------KFSPASKDFCEALLQKDPEKRLGFRDGSCDGLRTHPL 451 Query: 340 FDELRDPNVK 349 F ++ ++ Sbjct: 452 FRDISWRQLE 461 >5O2C-A nrPDB Length = 380 Score = 206 bits (523), Expect = 2e-53, Method: Composition-based stats. Identities = 62/303 (20%), Positives = 116/303 (38%), Gaps = 42/303 (13%) Query: 62 IGNGSFGVVYQAKLCDSGELVAI------KKVLQDKRFKNRELQIMRKLDHCNIVRLRYF 115 +G G+F VY+ ++ VA K +++ E ++++ L H NIVR Sbjct: 33 LGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDS 92 Query: 116 FYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSF 175 + S K + + LV + + + Y + + + ++ + Q+ + L ++H+ Sbjct: 93 WESIL--KGKKCIVLVTELMTSGT---LKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTR 147 Query: 176 G--ICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATD 233 I HRD+K N+ + T +K+ D G A L+R S I + + APE+ Sbjct: 148 TPPIIHRDLKCDNIFITGPTGSVKIGDLGLAT-LMRTSFAKSVIGTPEFMAPEMY--EEH 204 Query: 234 YTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKF 293 Y S+DV++ G + E+ + + Q+ + P Sbjct: 205 YDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPAS--------------- 249 Query: 294 PQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNG 353 F T PE + + + RL+ + H+FF E V+L Sbjct: 250 -----------FNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRVELAEE 298 Query: 354 RDT 356 D Sbjct: 299 DDC 301 >4YFF-A nrPDB Length = 311 Score = 205 bits (522), Expect = 2e-53, Method: Composition-based stats. Identities = 59/253 (23%), Positives = 103/253 (40%), Gaps = 23/253 (9%) Query: 16 PVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKL 75 V PS G +K + + P + E+ + ++IG+GSFG VY+ + Sbjct: 6 YVSVPSPLGKIKSMTKEKADILLLRAGLPSHFHLQLSEIEFH--EIIGSGSFGKVYKGRC 63 Query: 76 CDSGELVAIKKV-------LQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYL 128 ++VAIK+ D RE+ I+ +L+H +++ D Sbjct: 64 R--NKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVIQFVGACL-----NDPSQF 116 Query: 129 NLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHS--FGICHRDIKPQN 186 +V Y+ H K+ L + + + + + Y+H+ I HRD+ N Sbjct: 117 AIVTQYISGGSLFSLLH--EQKRILDLQSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHN 174 Query: 187 LLLDPDTAVLKLCDFGSAKQLV--RGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAG 244 +LL D + + DFG ++ L + + + APE+ T YT DV+S Sbjct: 175 ILLYEDGHAV-VADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTRYTIKADVFSYA 233 Query: 245 CVLAELLLGQPIF 257 L E+L G+ F Sbjct: 234 LCLWEILTGEIPF 246 >5O2B-A nrPDB Length = 285 Score = 205 bits (521), Expect = 4e-53, Method: Composition-based stats. Identities = 59/289 (20%), Positives = 112/289 (38%), Gaps = 42/289 (14%) Query: 62 IGNGSFGVVYQAKLCDSGELVAI------KKVLQDKRFKNRELQIMRKLDHCNIVRLRYF 115 +G G+F VY+ ++ VA K +++ E ++++ L H NIVR Sbjct: 24 LGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDS 83 Query: 116 FYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSF 175 + S K + + LV + + + Y + + + ++ + Q+ + L ++H+ Sbjct: 84 WESIL--KGKKCIVLVTELMTSGT---LKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTR 138 Query: 176 G--ICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATD 233 I HRD+K N+ + T +K+ D G A L+R S I + + APE+ Sbjct: 139 TPPIIHRDLKCDNIFITGPTGSVKIGDLGLAT-LMRTSFAKSVIGTPEFMAPEMY--EEH 195 Query: 234 YTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKF 293 Y S+DV++ G + E+ + + Q+ + P Sbjct: 196 YDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPAS--------------- 240 Query: 294 PQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDE 342 F T PE + + + RL+ + H+FF E Sbjct: 241 -----------FNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAE 278 >4KIK-B nrPDB Length = 677 Score = 204 bits (520), Expect = 5e-53, Method: Composition-based stats. Identities = 70/282 (24%), Positives = 115/282 (40%), Gaps = 13/282 (4%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRE-----LQIMRKLDHCNIV 110 + + +G G FG V + ++GE +AIK+ Q+ +NRE +QIMR+L H N+V Sbjct: 21 WEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQIMRRLTHPNVV 80 Query: 111 RLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLA 170 R L ++Y R + L + + + +L Sbjct: 81 AARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALR 140 Query: 171 YIHSFGICHRDIKPQNLLLDPDTAVL--KLCDFGSAKQLVRGEPNVSYICSRYYRAPELI 228 Y+H I HRD+KP+N++L L K+ D G AK+L +G S++ + Y APEL+ Sbjct: 141 YLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELL 200 Query: 229 FGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNY 288 YT ++D WS G + E + G F + Q ++ ++N Sbjct: 201 EQ-QKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLN--- 256 Query: 289 TEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLT 330 KF + P+ +L + P R T Sbjct: 257 GTVKFSS--SLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGT 296 >2WTK-C nrPDB Length = 305 Score = 204 bits (520), Expect = 5e-53, Method: Composition-based stats. Identities = 76/321 (23%), Positives = 133/321 (41%), Gaps = 51/321 (15%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVL--------QDKRFKNRELQIMRKLDHC 107 Y ++G GS+G V + ++ A+K + + +E+Q++R+L H Sbjct: 7 YLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHK 66 Query: 108 NIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFR 167 N+++L Y+ ++K + +V++Y + + S ++ PV Y QL Sbjct: 67 NVIQLVDVLYNEEKQK----MYMVMEYCVCGMQEMLD--SVPEKRFPVCQAHGYFCQLID 120 Query: 168 SLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVR---GEPNVSYICSRYYRA 224 L Y+HS GI H+DIKP NLLL LK+ G A+ L + + S ++ Sbjct: 121 GLEYLHSQGIVHKDIKPGNLLLTT-GGTLKISALGVAEALHPFAADDTCRTSQGSPAFQP 179 Query: 225 PELIFGATDY-TSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIRE 283 PE+ G + +D+WSAG L + G F GD+ + ++ + +G + Sbjct: 180 PEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDN----IYKLFENIGKGS------ 229 Query: 284 MNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDEL 343 + P P + L +LEY P R + + HS+F + Sbjct: 230 -------YAIPGDCGPPLS------------DLLKGMLEYEPAKRFSIRQIRQHSWFRKK 270 Query: 344 RDP---NVKLPNGRDTPALFN 361 P V +P DT + Sbjct: 271 HPPAEAPVPIPPSPDTKDRWR 291 >5VO2-A nrPDB Length = 300 Score = 203 bits (517), Expect = 1e-52, Method: Composition-based stats. Identities = 64/295 (21%), Positives = 117/295 (39%), Gaps = 46/295 (15%) Query: 46 QGPDRPQEVSYT---DTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMR 102 G + EV + D + +G+G+ G V+ + GE VA+KKV + K +++ +R Sbjct: 1 MGSEDLWEVPFEEILDLQWVGSGAQGAVFLGRFH--GEEVAVKKV---RDLKETDIKHLR 55 Query: 103 KLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYM 162 KL H NI+ + +++++ + RA + + + + Sbjct: 56 KLKHPNIITFKGVC------TQAPCYCILMEFCAQG---QLYEVLRAGRPVTPSLLVDWS 106 Query: 163 YQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYY 222 + + Y+H I HRD+K N+L+ D V+K+ DFG++K+L +S+ + + Sbjct: 107 MGIAGGMNYLHLHKIIHRDLKSPNMLITYDD-VVKISDFGTSKELSDKSTKMSFAGTVAW 165 Query: 223 RAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIR 282 APE+I + +D+WS G VL ELL G+ + II +G+ Sbjct: 166 MAPEVIRN-EPVSEKVDIWSFGVVLWELLTGEIPYKDVDSS----AIIWGVGS------- 213 Query: 283 EMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAH 337 + P L + P R + + H Sbjct: 214 ----------------NSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLH 252 >3BEA-A nrPDB Length = 333 Score = 203 bits (517), Expect = 1e-52, Method: Composition-based stats. Identities = 82/336 (24%), Positives = 131/336 (38%), Gaps = 49/336 (14%) Query: 15 KPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGP-DRPQEV---SYTDTKVIGNGSFGVV 70 K Q+P K+ +G+ T + P Q P + E + K +G G+FG V Sbjct: 5 KYKQKPKYQVRWKIIESYEGNSYTFI--DPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKV 62 Query: 71 YQAKLCDSGEL-----VAIKKVLQ-----DKRFKNRELQIMRKL-DHCNIVRLRYFFYSS 119 +A G+ VA+K + +K EL+IM L H NIV L Sbjct: 63 VEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHG 122 Query: 120 GEKKDEVYLNLVLDYVP-ETVYRVARHYSR----------AKQTLPVIYVKLYMYQLFRS 168 G + ++ +Y + R SR A TL + + Q+ + Sbjct: 123 GP------VLVITEYCCYGDLLNFLRRKSRVLETDPAFAIANSTLSTRDLLHFSSQVAQG 176 Query: 169 LAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY---YRAP 225 +A++ S HRD+ +N+LL + V K+ DFG A+ ++ + +R + AP Sbjct: 177 MAFLASKNCIHRDVAARNVLLT-NGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAP 235 Query: 226 ELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREM 284 E IF YT DVWS G +L E+ G +PG + +++K + + Sbjct: 236 ESIFDCV-YTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVK-------DGYQMA 287 Query: 285 NPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRL 320 P + I W P P +CS L Sbjct: 288 QPAFAPKNIYSIMQACWA--LEPTHRPTFQQICSFL 321 >5MJB-A nrPDB Length = 305 Score = 203 bits (516), Expect = 1e-52, Method: Composition-based stats. Identities = 67/286 (23%), Positives = 112/286 (39%), Gaps = 35/286 (12%) Query: 57 TDTKVIGNGSFGVVYQAKLCDSGE---LVAIKKVLQDKRFKNR-----ELQIMRKLDHCN 108 +VIG G FG VY+ +L G+ VAIK + K R E IM + DH N Sbjct: 29 KIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHRN 88 Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRS 168 I+RL S + ++ +++ + + VI + + + Sbjct: 89 IIRLEGVVTKSRP------VMIITEFMENCALDSFLRQNDGQ--FTVIQLVGMLRGIAAG 140 Query: 169 LAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY------Y 222 + Y+ HRD+ +N+L++ + V K+ DFG ++ L + +Y S + Sbjct: 141 MKYLSEMNYVHRDLAARNILVNSNL-VCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRW 199 Query: 223 RAPELIFGATDYTSSIDVWSAGCVLAE-LLLGQPIFPGDSGVDQLVEIIKVLGTPTREQI 281 APE I +TS+ DVWS G V+ E + G+ + S D + I + Sbjct: 200 TAPEAI-AYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAI--------EQDY 250 Query: 282 REMNPNYTEFKFPQIKAHPWTKVFRPRTP-PEAIALCSRLLEYTPT 326 R P Q+ W K R E + +++ P Sbjct: 251 RLPPPMDCPAALHQLMLDCWQKDRNSRPRFAEIVNTLDKMIR-NPA 295 >3HMP-A nrPDB Length = 342 Score = 203 bits (516), Expect = 1e-52, Method: Composition-based stats. Identities = 73/323 (22%), Positives = 126/323 (39%), Gaps = 60/323 (18%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN------RELQIMRKLDHCN- 108 Y+ K IG+G V+Q L + ++ AIK V ++ E+ + KL + Sbjct: 58 YSILKQIGSGGSSKVFQV-LNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 116 Query: 109 -IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFR 167 I+RL + + + Y+ +V++ + + + K+++ K Y + Sbjct: 117 KIIRLYDY------EITDQYIYMVMECGNIDL----NSWLKKKKSIDPWERKSYWKNMLE 166 Query: 168 SLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNV---SYICSRYYRA 224 ++ IH GI H D+KP N L+ +LKL DFG A Q+ +V S + + Y Sbjct: 167 AVHTIHQHGIVHSDLKPANFLIV--DGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMP 224 Query: 225 PELIFG----------ATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLG 274 PE I + + DVWS GC+L + G+ F Q++ I L Sbjct: 225 PEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF------QQIINQISKLH 278 Query: 275 TPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEA 334 ++PN+ E +FP I + L+ P R++ E Sbjct: 279 AI-------IDPNH-EIEFPDIPEKDLQ------------DVLKCCLKRDPKQRISIPEL 318 Query: 335 CAHSFFDELRDPNVKLPNGRDTP 357 AH + P ++ G Sbjct: 319 LAHPYVQIQTHPVNQMAKGTTEE 341 >3M42-A nrPDB Length = 299 Score = 203 bits (516), Expect = 1e-52, Method: Composition-based stats. Identities = 77/306 (25%), Positives = 122/306 (39%), Gaps = 52/306 (16%) Query: 54 VSYTDT-KVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKL-DHCNIVR 111 Y T +V+G G G V Q + E A+K +LQD RE+++ + +IVR Sbjct: 17 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALK-MLQDCPKARREVELHWRASQCPHIVR 75 Query: 112 LRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAY 171 + + + + L +V++ + +R R Q M + ++ Y Sbjct: 76 IVDVYENLYAGRK--CLLIVMECLDGGEL-FSRIQDRGDQAFTEREASEIMKSIGEAIQY 132 Query: 172 IHSFGICHRDIKPQNLLLDPD--TAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIF 229 +HS I HRD+KP+NLL A+LKL DFG AK+ Sbjct: 133 LHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT--------------------- 171 Query: 230 GATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYT 289 Y S D+WS G ++ LL G P F + G+ + + +IR Sbjct: 172 -GEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGL--------AISPGMKTRIRM-----G 217 Query: 290 EFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF-DELRDPNV 348 +++FP + W++V E L LL+ PT R+T E H + + P Sbjct: 218 QYEFPNPE---WSEV-----SEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQT 269 Query: 349 KLPNGR 354 L R Sbjct: 270 PLHTSR 275 >4OTD-A nrPDB Length = 341 Score = 203 bits (516), Expect = 2e-52, Method: Composition-based stats. Identities = 79/345 (22%), Positives = 130/345 (37%), Gaps = 65/345 (18%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQ-------IMRKLD-- 105 + V+G G FG V ++ SGEL AIK + + E++ I+ + Sbjct: 13 DFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTSA 72 Query: 106 -HCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQ 164 H +V L F + ++ V++Y + H Y Sbjct: 73 GHPFLVNLFGCF------QTPEHVCFVMEYSAGGDLMLHIH----SDVFSEPRAIFYSAC 122 Query: 165 LFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ-LVRGEPNVSYICSRYYR 223 + L ++H I +RD+K NLLLD + V K+ DFG K+ + G+ ++ + + Sbjct: 123 VVLGLQFLHEHKIVYRDLKLDNLLLDTEGYV-KIADFGLCKEGMGYGDRTSTFCGTPEFL 181 Query: 224 APELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIRE 283 APE++ + YT ++D W G +L E+L+G+ FPGD + I+ Sbjct: 182 APEVLTDTS-YTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVN------------ 228 Query: 284 MNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARL-----TPLEACAHS 338 E ++P+ EAI + RLL P RL + Sbjct: 229 -----DEVRYPRF------------LSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQP 271 Query: 339 FFDEL--------RDPNVKLPNGRDTPALFNFTTQELSSNPPLAT 375 FF L R P +P + NF + P L+ Sbjct: 272 FFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDEEFTGEAPTLSP 316 >5AP3-A nrPDB Length = 313 Score = 202 bits (515), Expect = 2e-52, Method: Composition-based stats. Identities = 73/323 (22%), Positives = 126/323 (39%), Gaps = 60/323 (18%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN------RELQIMRKLDHCN- 108 Y+ K IG+G V+Q L + ++ AIK V ++ E+ + KL + Sbjct: 30 YSILKQIGSGGSSKVFQV-LNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 88 Query: 109 -IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFR 167 I+RL + + + Y+ +V++ + + + K+++ K Y + Sbjct: 89 KIIRLYDY------EITDQYIYMVMECGNIDLNG----WLKKKKSIDPWERKSYWKNMLE 138 Query: 168 SLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNV---SYICSRYYRA 224 ++ IH GI H D+KP N L+ +LKL DFG A Q+ +V S + + Y Sbjct: 139 AVHTIHQHGIVHSDLKPANFLIV--DGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMP 196 Query: 225 PELIFG----------ATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLG 274 PE I + + DVWS GC+L + G+ F Q++ I L Sbjct: 197 PEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF------QQIINQISKLH 250 Query: 275 TPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEA 334 ++PN+ E +FP I + L+ P R++ E Sbjct: 251 AI-------IDPNH-EIEFPDIPEKDLQ------------DVLKCCLKRDPKQRISIPEL 290 Query: 335 CAHSFFDELRDPNVKLPNGRDTP 357 AH + P ++ G Sbjct: 291 LAHPYVQIQTHPVNQMAKGTTEE 313 >6DBM-A nrPDB Length = 318 Score = 202 bits (515), Expect = 2e-52, Method: Composition-based stats. Identities = 75/319 (23%), Positives = 125/319 (39%), Gaps = 39/319 (12%) Query: 40 VVATPGQGPDRPQEVSYTDTKVIGNGSFGVV----YQAKLCDSGELVAIKKVLQDKRFKN 95 + PG P + + +G G FG V Y +GE+VA+K + D ++ Sbjct: 18 LFQGPGD-PTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAGPQH 76 Query: 96 R-----ELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAK 150 R E+ I+R L H +I++ + +G L LV++YVP R + Sbjct: 77 RSGWKQEIDILRTLYHEHIIKYKGCCEDAGAAS----LQLVMEYVPLGSLRDYL----PR 128 Query: 151 QTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRG 210 ++ + + L+ Q+ +AY+HS HRD+ +N+LLD D V K+ DFG AK + G Sbjct: 129 HSIGLAQLLLFAQQICEGMAYLHSQHYIHRDLAARNVLLDNDRLV-KIGDFGLAKAVPEG 187 Query: 211 EPNVSYI----CSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQL 266 ++ APE + Y + DVWS G L ELL DS Sbjct: 188 HEYYRVREDGDSPVFWYAPECLKEYKFY-YASDVWSFGVTLYELLT-----HCDSSQSPP 241 Query: 267 VEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPT 326 + ++++G + T + ++ + P E L E + Sbjct: 242 TKFLELIGIAQGQM--------TVLRLTELLERGERLPRPDKCPAEVYHLMKNCWETEAS 293 Query: 327 ARLTPLEACAHSFFDELRD 345 R T + + Sbjct: 294 FRPTFENLI--PILKTVHE 310 >3KRL-A nrPDB Length = 335 Score = 202 bits (513), Expect = 3e-52, Method: Composition-based stats. Identities = 78/338 (23%), Positives = 129/338 (38%), Gaps = 51/338 (15%) Query: 15 KPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGP-DRPQEV---SYTDTKVIGNGSFGVV 70 K Q+P K+ +G+ T + P Q P + E + K +G G+FG V Sbjct: 5 KYKQKPKYQVRWKIIESYEGNSYTFI--DPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKV 62 Query: 71 YQAKLCDSGEL-----VAIKKVLQ-----DKRFKNRELQIMRKL-DHCNIVRLRYFFYSS 119 +A G+ VA+K + +K EL+IM L H NIV L Sbjct: 63 VEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHG 122 Query: 120 GEKKDEVYLNLVLDYV-------------PETVYRVARHYSRAKQTLPVIYVKLYMYQLF 166 G + ++ +Y P + ++ L + + Q+ Sbjct: 123 GP------VLVITEYCCYGDLLNFLRRKRPPGLEYSYNPSHNPEEQLSSRDLLHFSSQVA 176 Query: 167 RSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY---YR 223 + +A++ S HRD+ +N+LL + V K+ DFG A+ ++ + +R + Sbjct: 177 QGMAFLASKNCIHRDVAARNVLLT-NGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWM 235 Query: 224 APELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIR 282 APE IF YT DVWS G +L E+ G +PG + +++K + + Sbjct: 236 APESIFDCV-YTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVK-------DGYQ 287 Query: 283 EMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRL 320 P + I W P P +CS L Sbjct: 288 MAQPAFAPKNIYSIMQACWA--LEPTHRPTFQQICSFL 323 >4UY9-A nrPDB Length = 323 Score = 202 bits (513), Expect = 3e-52, Method: Composition-based stats. Identities = 79/331 (23%), Positives = 125/331 (37%), Gaps = 58/331 (17%) Query: 57 TDTKVIGNGSFGVVYQAKLCDSGELVAIKK--------VLQDKRFKNRELQIMRKLDHCN 108 T ++IG G FG VY+A G+ VA+K + Q +E ++ L H N Sbjct: 12 TLEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPN 69 Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRS 168 I+ LR E L LV+++ R +P + + Q+ R Sbjct: 70 IIALRGVCLK------EPNLCLVMEFARGGPLNRVLSGKR----IPPDILVNWAVQIARG 119 Query: 169 LAYIHSFGI---CHRDIKPQNLLL-------DPDTAVLKLCDFGSAKQLVRGEPNVSYIC 218 + Y+H I HRD+K N+L+ D +LK+ DFG A++ R +S Sbjct: 120 MNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHR-TTKMSAAG 178 Query: 219 SRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTR 278 + + APE+I + ++ DVWS G +L ELL G+ F G +D L V Sbjct: 179 TYAWMAPEVIRASM-FSKGSDVWSYGVLLWELLTGEVPFRG---IDGLAVAYGVAMNKLA 234 Query: 279 EQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYT-------PTARLTP 331 I P F ++ W P + P + +L P Sbjct: 235 LPIPSTCPEP----FAKLMEDCWN--PDPHSRPSFTNILDQLTTIEESGFFEMPK---DS 285 Query: 332 LEACAHSF-------FDELRDPNVKLPNGRD 355 ++ FD+LR +L + Sbjct: 286 FHCLQDNWKHEIQEMFDQLRAKEKELRTWEE 316 >4UYA-A nrPDB Length = 340 Score = 202 bits (513), Expect = 3e-52, Method: Composition-based stats. Identities = 70/282 (24%), Positives = 117/282 (41%), Gaps = 41/282 (14%) Query: 57 TDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQD--------KRFKNRELQIMRKLDHCN 108 ++IG G FG VY+A G+ VA+K QD RE ++ L H N Sbjct: 29 ELKELIGAGGFGQVYRATWQ--GQEVAVKAARQDPEQDAAAAAESVRREARLFAMLRHPN 86 Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRS 168 I+ LR + +L LVL++ + + A + +P + + Q+ R Sbjct: 87 IIELRGVCL------QQPHLCLVLEFARGGAL----NRALAGRRIPPHVLVNWAVQIARG 136 Query: 169 LAYIHSFG---ICHRDIKPQNLLL-------DPDTAVLKLCDFGSAKQLVRGEPNVSYIC 218 + Y+H I HRD+K N+LL D LK+ DFG A++ R + Sbjct: 137 MLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKMAT-AG 195 Query: 219 SRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTR 278 + + APE+I ++ ++ D+WS G +L ELL G+ + G G + V Sbjct: 196 AYAWMAPEVI-KSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDG-------LAVAYGVAV 247 Query: 279 EQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRL 320 ++ P+ F ++ W + P P + +L Sbjct: 248 NKLTLPIPSTCPEPFAKLMKECWQQ--DPHIRPSFALILEQL 287 >2WTK-B nrPDB Length = 373 Score = 201 bits (512), Expect = 4e-52, Method: Composition-based stats. Identities = 72/372 (19%), Positives = 133/372 (35%), Gaps = 60/372 (16%) Query: 51 PQEVSYTDTKVIGNGSF---GVVYQAKLCDSGELVAIKKVLQDK------RFKNRELQIM 101 P+ Y VIG G F V A+ +GE V ++++ + F EL + Sbjct: 6 PEGGCYELLTVIGKG-FEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVS 64 Query: 102 RKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLY 161 + +H NIV R F + E L +V ++ + + + + + Sbjct: 65 KLFNHPNIVPYRATFIADNE------LWVVTSFMAYGSAKDLI-CTHFMDGMNELAIAYI 117 Query: 162 MYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAV--------LKLCDFGSAKQLVRGEPN 213 + + ++L YIH G HR +K ++L+ D V L + G +++V P Sbjct: 118 LQGVLKALDYIHHMGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPK 177 Query: 214 VSYICSRYYRAPELIFGA-TDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIK- 271 S + +PE++ Y + D++S G EL G F L+E + Sbjct: 178 YSVKVLP-WLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNG 236 Query: 272 -----------------------VLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPR 308 V + + + P + P +HP+ + F P Sbjct: 237 TVPCLLDTSTIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSP---SHPYHRTFSPH 293 Query: 309 TPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVK-LPN-GRDTPALFNFTTQE 366 + L+ P AR + HSFF +++ + LP R + NF + Sbjct: 294 FH----HFVEQCLQRNPDARPSASTLLNHSFFKQIKRRASEALPELLRPVTPITNFEGSQ 349 Query: 367 LSSNPPLATILI 378 + + ++ Sbjct: 350 SQDHSGIFGLVT 361 >5KKR-C nrPDB Length = 395 Score = 201 bits (511), Expect = 5e-52, Method: Composition-based stats. Identities = 70/348 (20%), Positives = 129/348 (37%), Gaps = 33/348 (9%) Query: 27 KVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKK 86 ++ D+ K T Q ++ + +G G+ GVV++ SG ++A K Sbjct: 41 ELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKL 100 Query: 87 VLQDKR-----FKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYR 141 + + + RELQ++ + + IV FYS GE +++ ++++ Sbjct: 101 IHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGE------ISICMEHMDGGSLD 154 Query: 142 VARHYSRAKQTLPVIYVKLYMYQLFRSLAYI-HSFGICHRDIKPQNLLLDPDTAVLKLCD 200 + +P + + + L Y+ I HRD+KP N+L++ +KLCD Sbjct: 155 ---QVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGE-IKLCD 210 Query: 201 FGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGD 260 FG + QL+ N S++ +R Y +PE + G T Y+ D+WS G L E+ +G+ P Sbjct: 211 FGVSGQLIDSMAN-SFVGTRSYMSPERLQG-THYSVQSDIWSMGLSLVEMAVGRYPIPPP 268 Query: 261 SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVF--------------- 305 + + + E + + P +F Sbjct: 269 DAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLP 328 Query: 306 RPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNG 353 E ++ L P R + H+F V Sbjct: 329 SAVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGW 376 >4E20-A nrPDB Length = 290 Score = 201 bits (511), Expect = 5e-52, Method: Composition-based stats. Identities = 72/297 (24%), Positives = 119/297 (40%), Gaps = 36/297 (12%) Query: 47 GPDRPQEVSYTDTKVIGNGSFGVV----YQAKLCDSGELVAIKKVLQD-----KRFKNRE 97 P + + +G G FG V Y +GE+VA+K + + + RE Sbjct: 1 DPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSGWQRE 60 Query: 98 LQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIY 157 ++I+R L H +IV+ + GEK + LV++YVP R + + + Sbjct: 61 IEILRTLYHEHIVKYKGCCEDQGEKS----VQLVMEYVPLGSLRDYL----PRHCVGLAQ 112 Query: 158 VKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYI 217 + L+ Q+ +AY+H+ HR + +N+LLD D ++K+ DFG AK + G Sbjct: 113 LLLFAQQICEGMAYLHAQHYIHRALAARNVLLDNDR-LVKIGDFGLAKAVPEGHEYYRVR 171 Query: 218 ----CSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVL 273 ++ APE + Y + DVWS G L ELL DS + +++ Sbjct: 172 EDGDSPVFWYAPECLKECKFY-YASDVWSFGVTLYELLT-----YCDSNQSPHTKFTELI 225 Query: 274 GTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLT 330 G + T + ++ R P E L E + R T Sbjct: 226 GHTQGQM--------TVLRLTELLERGERLPRPDRCPCEIYHLMKNCWETEASFRPT 274 >6CCF-A nrPDB Length = 290 Score = 201 bits (511), Expect = 5e-52, Method: Composition-based stats. Identities = 76/323 (23%), Positives = 112/323 (34%), Gaps = 71/323 (21%) Query: 51 PQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAI-------------------------- 84 Q Y IG G++GVV A A+ Sbjct: 2 MQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAA 61 Query: 85 -----KKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETV 139 K++L +R E+ I++KLDH N+V+L E L LV D + + Sbjct: 62 QGGPAKQLLPLERVYQ-EIAILKKLDHVNVVKLIEVLDDPAEDN----LYLVFDLLRKG- 115 Query: 140 YRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLC 199 + +LY+ + L Y+H I HRDIKP NLLL D V K+ Sbjct: 116 ---PVMEVPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHV-KIA 171 Query: 200 DFGSAKQLV-RGEPNVSYICSRYYRAPELI--FGATDYTSSIDVWSAGCVLAELLLGQPI 256 DFG + Q S + + APE I G + ++DVW+ G L + G+ Sbjct: 172 DFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCP 231 Query: 257 FPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIAL 316 F D + L IK FP+ P E L Sbjct: 232 FI-DDFILALHRKIK----------------NEPVVFPE----------EPEISEELKDL 264 Query: 317 CSRLLEYTPTARLTPLEACAHSF 339 ++L+ P R+ + H + Sbjct: 265 ILKMLDKNPETRIGVPDIKLHPW 287 >5H2U-A nrPDB Length = 267 Score = 201 bits (510), Expect = 6e-52, Method: Composition-based stats. Identities = 67/278 (24%), Positives = 118/278 (42%), Gaps = 27/278 (9%) Query: 49 DRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQD----KRFKNRELQIMRKL 104 +RP+E +T + +G+G FG V++ D VAIK + +D ++ E+Q M+KL Sbjct: 2 ERPRE-EFTLCRKLGSGYFGEVFEGLWKD-RVQVAIKVISRDNLLHQQMLQSEIQAMKKL 59 Query: 105 DHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQ 164 H +I+ L + ++ + + + S ++ LPV + +Q Sbjct: 60 RHKHILALYAVVSVGDP------VYIITELMAKGSLLELLRDSD-EKVLPVSELLDIAWQ 112 Query: 165 LFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY-YR 223 + + Y+ S HRD+ +N+L+ +T + K+ DFG A+ + Y + Sbjct: 113 VAEGMCYLESQNYIHRDLAARNILVGENT-LCKVGDFGLARLIKEDVYLSHDHNIPYKWT 171 Query: 224 APELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIR 282 APE + Y++ DVWS G +L E+ GQ +PG S + + + R Sbjct: 172 APEAL-SRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRV--------DAGYR 222 Query: 283 EMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRL 320 P ++ W + P P AL RL Sbjct: 223 MPCPLECPPSVHKLMLTCWCR--DPEQRPTFKALRERL 258 >3BGP-A nrPDB Length = 333 Score = 201 bits (510), Expect = 7e-52, Method: Composition-based stats. Identities = 75/317 (23%), Positives = 123/317 (38%), Gaps = 57/317 (17%) Query: 43 TPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN------- 95 PG+ + P E Y ++G+G FG VY VAIK V +D+ Sbjct: 46 APGKEKE-PLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGT 104 Query: 96 ---RELQIMRKLDH--CNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAK 150 E+ +++K+ ++RL +F L+L+ PE V + + + Sbjct: 105 RVPMEVVLLKKVSSGFSGVIRLLDWFERPDS------FVLILE-RPEPVQDLF-DFITER 156 Query: 151 QTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRG 210 L + + +Q+ ++ + H+ G+ HRDIK +N+L+D + LKL DFG + L++ Sbjct: 157 GALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFG-SGALLKD 215 Query: 211 EPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEII 270 + +R Y PE I + S VWS G +L +++ G F D EII Sbjct: 216 TVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDE------EII 269 Query: 271 KVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLT 330 + FR R E L L P+ R T Sbjct: 270 RG-----------------------------QVFFRQRVSSECQHLIRWCLALRPSDRPT 300 Query: 331 PLEACAHSFFDELRDPN 347 E H + ++ P Sbjct: 301 FEEIQNHPWMQDVLLPQ 317 >3EQC-A nrPDB Length = 360 Score = 201 bits (510), Expect = 7e-52, Method: Composition-based stats. Identities = 77/348 (22%), Positives = 135/348 (38%), Gaps = 33/348 (9%) Query: 27 KVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKK 86 ++ D+ K T Q ++ + +G G+ GVV++ SG ++A K Sbjct: 6 ELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKL 65 Query: 87 VLQDKR-----FKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYR 141 + + + RELQ++ + + IV FYS GE +++ ++++ Sbjct: 66 IHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGE------ISICMEHMDGGSLD 119 Query: 142 VARHYSRAKQTLPVIYVKLYMYQLFRSLAYI-HSFGICHRDIKPQNLLLDPDTAVLKLCD 200 + +P + + + L Y+ I HRD+KP N+L++ +KLCD Sbjct: 120 ---QVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGE-IKLCD 175 Query: 201 FGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGD 260 FG + QL+ N S++ +R Y +PE + G T Y+ D+WS G L E+ +G+ P Sbjct: 176 FGVSGQLIDSMAN-SFVGTRSYMSPERLQG-THYSVQSDIWSMGLSLVEMAVGRYPIPPP 233 Query: 261 SGVD-QLVEIIKVLGTPTREQIREMNPNYTEFKF--------------PQIKAHPWTKVF 305 + +L+ +V G R P KF I P K+ Sbjct: 234 DAKELELMFGCQVEGDAAETPPRPRTPGRPLNKFGMDSRPPMAIFELLDYIVNEPPPKLP 293 Query: 306 RPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNG 353 E ++ L P R + H+F V Sbjct: 294 SGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGW 341 >2XNP-A nrPDB Length = 279 Score = 200 bits (509), Expect = 9e-52, Method: Composition-based stats. Identities = 76/308 (24%), Positives = 122/308 (39%), Gaps = 49/308 (15%) Query: 48 PDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKV------LQDKRFKNRELQIM 101 P R ++ Y IG GS+G + + G+++ K++ +K+ E+ ++ Sbjct: 2 PSRAED--YEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLL 59 Query: 102 RKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYV-PETVYRVARHYSRAKQTLPVIYVKL 160 R+L H NIVR +Y + L +V++Y + V ++ +Q L +V Sbjct: 60 RELKHPNIVR----YYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLR 115 Query: 161 YMYQLFRSLAYIHS-----FGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPN-V 214 M QL +L H + HRD+KP N+ LD V KL DFG A+ L Sbjct: 116 VMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNV-KLGDFGLARILNHDTSFAK 174 Query: 215 SYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLG 274 +++ + YY +PE Y D+WS GC+L EL P F S + +I Sbjct: 175 TFVGTPYYMSPEQ-MNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKI----- 228 Query: 275 TPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEA 334 E KF +I R E + +R+L R + E Sbjct: 229 --------------REGKFRRIP---------YRYSDELNEIITRMLNLKDYHRPSVEEI 265 Query: 335 CAHSFFDE 342 + E Sbjct: 266 LENPLILE 273 >2R2P-A nrPDB Length = 295 Score = 200 bits (508), Expect = 1e-51, Method: Composition-based stats. Identities = 68/284 (23%), Positives = 111/284 (39%), Gaps = 33/284 (11%) Query: 57 TDTKVIGNGSFGVVYQAKLCDSGEL---VAIKKVLQDKRFKNR-----ELQIMRKLDHCN 108 T +VIG G FG V +L G+ VAIK + K R E IM + DH N Sbjct: 25 TIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPN 84 Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRS 168 I+ L S + +V +Y+ + VI + + + Sbjct: 85 IIHLEGVVTKSKP------VMIVTEYMENGSLD--TFLKKNDGQFTVIQLVGMLRGISAG 136 Query: 169 LAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRG-EPNVSYICSR---YYRA 224 + Y+ G HRD+ +N+L++ + V K+ DFG ++ L E + + + A Sbjct: 137 MKYLSDMGYVHRDLAARNILINSNL-VCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTA 195 Query: 225 PELIFGATDYTSSIDVWSAGCVLAELL-LGQPIFPGDSGVDQLVEIIKVLGTPTREQIRE 283 PE I +TS+ DVWS G V+ E++ G+ + + D + + E R Sbjct: 196 PEAI-AFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAV--------EEGYRL 246 Query: 284 MNPNYTEFKFPQIKAHPWTKVFRPR-TPPEAIALCSRLLEYTPT 326 +P Q+ W K R E + + + L P Sbjct: 247 PSPMDCPAALYQLMLDCWQKERNSRPKFDEIVNMLDK-LIRNPA 289 >3QGY-A nrPDB Length = 286 Score = 200 bits (508), Expect = 1e-51, Method: Composition-based stats. Identities = 61/278 (21%), Positives = 115/278 (41%), Gaps = 31/278 (11%) Query: 50 RPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN---RELQIMRKLDH 106 P E+++ + IG+G FG+V+ + + VAIK + + ++ E ++M KL H Sbjct: 25 DPSELTF--VQEIGSGQFGLVHLGYWLNKDK-VAIKTIKEGSMSEDDFIEEAEVMMKLSH 81 Query: 107 CNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLF 166 +V+L ++ + LV +++ R + + Sbjct: 82 PKLVQLYGVCL------EQAPICLVFEFMEHGCLSDYLRTQRG--LFAAETLLGMCLDVC 133 Query: 167 RSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY---YR 223 +AY+ + HRD+ +N L+ + V+K+ DFG + V + S +++ + Sbjct: 134 EGMAYLEEACVIHRDLAARNCLVG-ENQVIKVSDFGMTR-FVLDDQYTSSTGTKFPVKWA 191 Query: 224 APELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIR 282 +PE+ F + Y+S DVWS G ++ E+ G+ + S + + +I R Sbjct: 192 SPEV-FSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDI--------STGFR 242 Query: 283 EMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRL 320 P QI H W + RP P L +L Sbjct: 243 LYKPRLASTHVYQIMNHCWKE--RPEDRPAFSRLLRQL 278 >3BBT-B nrPDB Length = 328 Score = 199 bits (507), Expect = 1e-51, Method: Composition-based stats. Identities = 75/342 (21%), Positives = 122/342 (35%), Gaps = 52/342 (15%) Query: 45 GQGPDRPQ-----EVSYTDTKVIGNGSFGVVYQAKLCDSGELV----AIKKVL-----QD 90 G P++ Q E KV+G+G+FG VY+ GE V AIK + + Sbjct: 1 GTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKA 60 Query: 91 KRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAK 150 E IM +DH ++VRL S + LV +P + + K Sbjct: 61 NVEFMDEALIMASMDHPHLVRLLGVCLSPT-------IQLVTQLMPHGC--LLEYVHEHK 111 Query: 151 QTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRG 210 + + + Q+ + + Y+ + HRD+ +N+L+ V K+ DFG A+ L Sbjct: 112 DNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHV-KITDFGLARLLEGD 170 Query: 211 EPNVSYICSRY---YRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQL 266 E + + + A E I +T DVWS G + EL+ G + G + Sbjct: 171 EKEYNADGGKMPIKWMALECIH-YRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTRE-- 227 Query: 267 VEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPW--TKVFRPRTPPEAIALCSRLLEYT 324 + + R P + W RP+ A SR+ Sbjct: 228 ------IPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEF-SRM-ARD 279 Query: 325 PTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQE 366 P + D +KLP+ D+ N +E Sbjct: 280 PQR-----------YLVIQGDDRMKLPSPNDSKFFQNLLDEE 310 >4AN9-A nrPDB Length = 301 Score = 199 bits (507), Expect = 1e-51, Method: Composition-based stats. Identities = 66/308 (21%), Positives = 120/308 (38%), Gaps = 45/308 (14%) Query: 52 QEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKR-----FKNRELQIMRKLDH 106 ++ + +G G+ GVV++ SG ++A K + + + RELQ++ + + Sbjct: 7 KDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNS 66 Query: 107 CNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLF 166 IV FYS GE +++ ++++ + +P + + Sbjct: 67 PYIVGFYGAFYSDGE------ISICMEHMDGGSLD---QVLKKAGRIPEQILGKVSIAVI 117 Query: 167 RSLAYI-HSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAP 225 + L Y+ I HRD+KP N+L++ +KLCDFG + QL+ E ++ +R Y +P Sbjct: 118 KGLTYLREKHKIMHRDVKPSNILVNSRGE-IKLCDFGVSGQLI-DEMANEFVGTRSYMSP 175 Query: 226 ELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMN 285 E + G T Y+ D+WS G L E+ +G+ P + + L I+ Sbjct: 176 ERLQG-THYSVQSDIWSMGLSLVEMAVGRYPRPPMAIFELLDYIVN-------------- 220 Query: 286 PNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRD 345 P K+ E ++ L P R + H+F Sbjct: 221 -------------EPPPKLPSAVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDA 267 Query: 346 PNVKLPNG 353 V Sbjct: 268 EEVDFAGW 275 >4RC3-A nrPDB Length = 289 Score = 199 bits (506), Expect = 2e-51, Method: Composition-based stats. Identities = 74/317 (23%), Positives = 120/317 (37%), Gaps = 56/317 (17%) Query: 43 TPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN------- 95 P P E Y ++G+G FG VY VAIK V +D+ Sbjct: 1 GPHMKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGT 60 Query: 96 ---RELQIMRKLDH--CNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAK 150 E+ +++K+ ++RL +F L+L+ PE V + + + Sbjct: 61 RVPMEVVLLKKVSSGFSGVIRLLDWFERPDS------FVLILE-RPEPVQDLF-DFITER 112 Query: 151 QTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRG 210 L + + +Q+ ++ + H+ G+ HRDIK +N+L+D + LKL DFG + L++ Sbjct: 113 GALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFG-SGALLKD 171 Query: 211 EPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEII 270 + +R Y PE I + S VWS G +L +++ G F D EII Sbjct: 172 TVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDE------EII 225 Query: 271 KVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLT 330 + FR R E L L P+ R T Sbjct: 226 RG-----------------------------QVFFRQRVSSECQHLIRWCLALRPSDRPT 256 Query: 331 PLEACAHSFFDELRDPN 347 E H + ++ P Sbjct: 257 FEEIQNHPWMQDVLLPQ 273 >3DKO-A nrPDB Length = 318 Score = 199 bits (506), Expect = 2e-51, Method: Composition-based stats. Identities = 64/284 (22%), Positives = 109/284 (38%), Gaps = 33/284 (11%) Query: 57 TDTKVIGNGSFGVVYQAKLCDSGEL---VAIKKVLQDKRFKNR-----ELQIMRKLDHCN 108 +VIG G FG V +L G+ VAIK + K R E IM + DH N Sbjct: 46 KIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHPN 105 Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRS 168 +V L + +V++++ + VI + + + Sbjct: 106 VVHLEGVVTRGKP------VMIVIEFMENGALD--AFLRKHDGQFTVIQLVGMLRGIAAG 157 Query: 169 LAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRG-EPNVSYICSR---YYRA 224 + Y+ G HRD+ +N+L++ + V K+ DFG ++ + E + + + A Sbjct: 158 MRYLADMGYVHRDLAARNILVNSNL-VCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTA 216 Query: 225 PELIFGATDYTSSIDVWSAGCVLAE-LLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIRE 283 PE I +TS+ DVWS G V+ E + G+ + S D + I E R Sbjct: 217 PEAI-QYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAI--------EEGYRL 267 Query: 284 MNPNYTEFKFPQIKAHPWTKVFRPR-TPPEAIALCSRLLEYTPT 326 P Q+ W K R + + + +++ P Sbjct: 268 PAPMDCPAGLHQLMLDCWQKERAERPKFEQIVGILDKMIR-NPN 310 >5L6P-A nrPDB Length = 298 Score = 199 bits (506), Expect = 2e-51, Method: Composition-based stats. Identities = 64/287 (22%), Positives = 110/287 (38%), Gaps = 37/287 (12%) Query: 57 TDTKVIGNGSFGVVYQAKLCDSGE---LVAIKKVLQDKRFKNR-----ELQIMRKLDHCN 108 +VIG G FG V + +L G VAIK + + R E IM + DH N Sbjct: 22 KIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQRRDFLSEASIMGQFDHPN 81 Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRS 168 I+RL S + ++ +++ + + VI + + + Sbjct: 82 IIRLEGVVTKSRP------VMILTEFMENCALDSFLRLNDGQ--FTVIQLVGMLRGIAAG 133 Query: 169 LAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY------Y 222 + Y+ HRD+ +N+L++ + V K+ DFG ++ L + +Y S + Sbjct: 134 MKYLSEMNYVHRDLAARNILVNSNL-VCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRW 192 Query: 223 RAPELIFGATDYTSSIDVWSAGCVLAE-LLLGQPIFPGDSGVDQLVEIIKVLGTPTREQI 281 APE I +TS+ DVWS G V+ E + G+ + S D + + + Sbjct: 193 TAPEAI-AYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAV--------EQDY 243 Query: 282 REMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRL--LEYTPT 326 R P Q+ W + P+ + + L L P Sbjct: 244 RLPPPMDCPTALHQLMLDCWVR--DRNLRPKFSQIVNTLDKLIRNPA 288 >3DTC-A nrPDB Length = 271 Score = 199 bits (506), Expect = 2e-51, Method: Composition-based stats. Identities = 73/282 (25%), Positives = 114/282 (40%), Gaps = 41/282 (14%) Query: 57 TDTKVIGNGSFGVVYQAKLCDSGELVAIKK--------VLQDKRFKNRELQIMRKLDHCN 108 T ++IG G FG VY+A G+ VA+K + Q +E ++ L H N Sbjct: 10 TLEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPN 67 Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRS 168 I+ LR E L LV+++ R +P + + Q+ R Sbjct: 68 IIALRGVCLK------EPNLCLVMEFARGGPLNRVLSGKR----IPPDILVNWAVQIARG 117 Query: 169 LAYIHSFGI---CHRDIKPQNLLL-------DPDTAVLKLCDFGSAKQLVRGEPNVSYIC 218 + Y+H I HRD+K N+L+ D +LK+ DFG A++ R +S Sbjct: 118 MNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHR-TTKMSAAG 176 Query: 219 SRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTR 278 + + APE+I + ++ DVWS G +L ELL G+ F G +D L V Sbjct: 177 AYAWMAPEVIRASM-FSKGSDVWSYGVLLWELLTGEVPFRG---IDGLAVAYGVAMNKLA 232 Query: 279 EQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRL 320 I P F ++ W P + P + +L Sbjct: 233 LPIPSTCPEP----FAKLMEDCWN--PDPHSRPSFTNILDQL 268 >2OGV-A nrPDB Length = 317 Score = 199 bits (505), Expect = 2e-51, Method: Composition-based stats. Identities = 77/328 (23%), Positives = 129/328 (39%), Gaps = 45/328 (13%) Query: 19 QPSAFGSMKVSRDKDGSKVTTVVATPGQGP-DRPQEV---SYTDTKVIGNGSFGVVYQAK 74 +P K+ +G+ T + P Q P + E + K +G G+FG V +A Sbjct: 1 KPKYQVRWKIIESYEGNSYTFI--DPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEAT 58 Query: 75 LCDSGEL-----VAIKKVLQ-----DKRFKNRELQIMRKL-DHCNIVRLRYFFYSSGEKK 123 G+ VA+K + +K EL+IM L H NIV L G Sbjct: 59 AFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGP-- 116 Query: 124 DEVYLNLVLDYVP-ETVYRVARHYSRAK------QTLPVIYVKLYMYQLFRSLAYIHSFG 176 + ++ +Y + R + A + L + + + Q+ + +A++ S Sbjct: 117 ----VLVITEYCCYGDLLNFLRRKAEADLDKEDGRPLELRDLLHFSSQVAQGMAFLASKN 172 Query: 177 ICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY---YRAPELIFGATD 233 HRD+ +N+LL + V K+ DFG A+ ++ + +R + APE IF Sbjct: 173 CIHRDVAARNVLLT-NGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCV- 230 Query: 234 YTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFK 292 YT DVWS G +L E+ G +PG + +++K + + P + Sbjct: 231 YTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVK-------DGYQMAQPAFAPKN 283 Query: 293 FPQIKAHPWTKVFRPRTPPEAIALCSRL 320 I W P P +CS L Sbjct: 284 IYSIMQACWA--LEPTHRPTFQQICSFL 309 >6BXI-A nrPDB Length = 333 Score = 199 bits (505), Expect = 3e-51, Method: Composition-based stats. Identities = 80/370 (21%), Positives = 136/370 (36%), Gaps = 94/370 (25%) Query: 50 RPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNR-------ELQIMR 102 R + KVIG G+FG V + D+G + A+K + + + E I+ Sbjct: 2 RLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILV 61 Query: 103 KLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYM 162 + D +V++ Y F +D++ L L+++++P K TL + Y+ Sbjct: 62 EADSLWVVKMFYSF------QDKLNLYLIMEFLPGGDMMTLLM---KKDTLTEEETQFYI 112 Query: 163 YQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNV-------- 214 + ++ IH G HRDIKP NLLLD V KL DFG L + Sbjct: 113 AETVLAIDSIHQLGFIHRDIKPDNLLLDSKGHV-KLSDFGLCTGLKKAHRTEFYRNLNHS 171 Query: 215 ----------------------------SYICSRYYRAPELIFGATDYTSSIDVWSAGCV 246 S + + Y APE+ T Y D WS G + Sbjct: 172 LPSDFTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQ-TGYNKLCDWWSLGVI 230 Query: 247 LAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFR 306 + E+L+G P F ++ + +++ T T P++ Sbjct: 231 MYEMLIGYPPFCSETPQETYKKVMNWKETLTFP--------------PEVP--------- 267 Query: 307 PRTPPEAIALCSR-LLEYTPTARLTP---LEACAHSFF-----DELRDP----NVKLPNG 353 +A L R E+ R+ E ++SFF + +R+ ++++ + Sbjct: 268 --ISEKAKDLILRFCCEWEH--RIGAPGVEEIKSNSFFEGVDWEHIRERPAAISIEIKSI 323 Query: 354 RDTPALFNFT 363 DT F Sbjct: 324 DDTSNFDEFP 333 >2VWV-A nrPDB Length = 302 Score = 198 bits (504), Expect = 3e-51, Method: Composition-based stats. Identities = 64/291 (21%), Positives = 116/291 (39%), Gaps = 36/291 (12%) Query: 53 EVSY-TDTKVIGNGSFGVVYQAKLCDSGEL---VAIKKVLQDKRFKNR-----ELQIMRK 103 +VSY +VIG G FG V + +L G+ VAIK + + R E IM + Sbjct: 14 DVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSEASIMGQ 73 Query: 104 LDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMY 163 +H NI+RL + + + ++ +++ + + VI + + Sbjct: 74 FEHPNIIRLEGVV------TNSMPVMILTEFMENGALDSFLRLNDGQ--FTVIQLVGMLR 125 Query: 164 QLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVR---GEPNVSYICSR 220 + + Y+ HRD+ +N+L++ + V K+ DFG ++ L S + + Sbjct: 126 GIASGMRYLAEMSYVHRDLAARNILVNSNL-VCKVSDFGLSRFLEENSSDPTETSSLGGK 184 Query: 221 ---YYRAPELIFGATDYTSSIDVWSAGCVLAE-LLLGQPIFPGDSGVDQLVEIIKVLGTP 276 + APE I +TS+ D WS G V+ E + G+ + S D + I Sbjct: 185 IPIRWTAPEAI-AFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAI------- 236 Query: 277 TREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTP-PEAIALCSRLLEYTPT 326 + R P Q+ W K R P+ ++ +++ P Sbjct: 237 -EQDYRLPPPPDCPTSLHQLMLDCWQKDRNARPRFPQVVSALDKMIR-NPA 285 >2W1I-A nrPDB Length = 326 Score = 198 bits (503), Expect = 4e-51, Method: Composition-based stats. Identities = 70/317 (22%), Positives = 134/317 (42%), Gaps = 44/317 (13%) Query: 46 QGPDRPQEVSYTDTKVIGNGSFGVVYQAKLC----DSGELVAIKKVLQDKRF----KNRE 97 + P + +E + +G G+FG V + ++GE+VA+KK+ RE Sbjct: 33 RDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFERE 92 Query: 98 LQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIY 157 ++I++ L H NIV+ + YS+G + L L+++Y+P R + + K+ + I Sbjct: 93 IEILKSLQHDNIVKYKGVCYSAGRRN----LKLIMEYLPYGSLR--DYLQKHKERIDHIK 146 Query: 158 VKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYI 217 + Y Q+ + + Y+ + HRD+ +N+L++ + V K+ DFG K L + + Sbjct: 147 LLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRV-KIGDFGLTKVLPQDKEYYKVK 205 Query: 218 ----CSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVL 273 ++ APE + + ++ + DVWS G VL EL I+ Sbjct: 206 EPGESPIFWYAPESLT-ESKFSVASDVWSFGVVLYELFT----------------YIEKS 248 Query: 274 GTPTREQIREMNPNYTE----FKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARL 329 +P E +R + + F ++ + P E + + R Sbjct: 249 KSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRP 308 Query: 330 TPLE-ACAHSFFDELRD 345 + + A D++RD Sbjct: 309 SFRDLALR---VDQIRD 322 >5TUR-A nrPDB Length = 404 Score = 198 bits (503), Expect = 4e-51, Method: Composition-based stats. Identities = 75/317 (23%), Positives = 123/317 (38%), Gaps = 57/317 (17%) Query: 43 TPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN------- 95 PG+ + P E Y ++G+G FG VY VAIK V +D+ Sbjct: 117 APGKEKE-PLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGT 175 Query: 96 ---RELQIMRKLDH--CNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAK 150 E+ +++K+ ++RL +F L+L+ PE V + + + Sbjct: 176 RVPMEVVLLKKVSSGFSGVIRLLDWFERPDS------FVLILE-RPEPVQDLF-DFITER 227 Query: 151 QTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRG 210 L + + +Q+ ++ + H+ G+ HRDIK +N+L+D + LKL DFG + L++ Sbjct: 228 GALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFG-SGALLKD 286 Query: 211 EPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEII 270 + +R Y PE I + S VWS G +L +++ G F D EII Sbjct: 287 TVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDE------EII 340 Query: 271 KVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLT 330 + FR R E L L P+ R T Sbjct: 341 RG-----------------------------QVFFRQRVSSECQHLIRWCLALRPSDRPT 371 Query: 331 PLEACAHSFFDELRDPN 347 E H + ++ P Sbjct: 372 FEEIQNHPWMQDVLLPQ 388 >2Y6O-A nrPDB Length = 291 Score = 197 bits (502), Expect = 5e-51, Method: Composition-based stats. Identities = 67/288 (23%), Positives = 107/288 (37%), Gaps = 35/288 (12%) Query: 57 TDTKVIGNGSFGVVYQAKLCDSGEL---VAIKKVLQDKRFKNR-----ELQIMRKLDHCN 108 KVIG G FG V +L G+ VAIK + K R E IM + DH N Sbjct: 17 KIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHPN 76 Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRS 168 I+ L + ++ +Y+ + VI + + + Sbjct: 77 IIHLEGVVTKCKP------VMIITEYMENGSLD--AFLRKNDGRFTVIQLVGMLRGIGSG 128 Query: 169 LAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRG-EPNVSYICSR---YYRA 224 + Y+ HRD+ +N+L++ + V K+ DFG ++ L E + + + A Sbjct: 129 MKYLSDMSYVHRDLAARNILVNSNL-VCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTA 187 Query: 225 PELIFGATDYTSSIDVWSAGCVLAE-LLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIRE 283 PE I +TS+ DVWS G V+ E + G+ + S D + I E R Sbjct: 188 PEAI-AYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAI--------EEGYRL 238 Query: 284 MNPNYTEFKFPQIKAHPWTKVFRPR-TPPEAIALCSRLLEYTPT--AR 328 P Q+ W K R + + + + L P R Sbjct: 239 PPPMDCPIALHQLMLDCWQKERSDRPKFGQIVNMLDK-LIRNPNSLKR 285 >2A1A-B nrPDB Length = 284 Score = 197 bits (502), Expect = 5e-51, Method: Composition-based stats. Identities = 64/298 (21%), Positives = 113/298 (37%), Gaps = 46/298 (15%) Query: 49 DRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCN 108 D+ + + + ++IG+G FG V++AK G+ IK+V + RE++ + KLDH N Sbjct: 6 DKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVN 65 Query: 109 IVRLRYFF----------YSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYV 158 IV + + + L + +++ + R ++ L + Sbjct: 66 IVHYNGCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEK-LDKVLA 124 Query: 159 KLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYIC 218 Q+ + + YIHS + +RD+KP N+ L DT +K+ DFG L Sbjct: 125 LELFEQITKGVDYIHSKKLINRDLKPSNIFL-VDTKQVKIGDFGLVTSLKNDGKRTRSKG 183 Query: 219 SRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTR 278 + Y +PE I + DY +D+++ G +LAELL Sbjct: 184 TLRYMSPEQI-SSQDYGKEVDLYALGLILAELL--------------------------- 215 Query: 279 EQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACA 336 + T F+ + + + L +LL P R E Sbjct: 216 ------HVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILR 267 >1ZXE-A nrPDB Length = 303 Score = 197 bits (501), Expect = 8e-51, Method: Composition-based stats. Identities = 67/311 (21%), Positives = 121/311 (38%), Gaps = 55/311 (17%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN---RELQIMRKLDHCNIVR 111 + + V+G G+FG V +A+ AIKK+ + + E+ ++ L+H +VR Sbjct: 7 DFEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRHTEEKLSTILSEVMLLASLNHQYVVR 66 Query: 112 LR-------YFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQ 164 F K + L + ++Y H Q + Q Sbjct: 67 YYAAWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQRDEYW--RLFRQ 124 Query: 165 LFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVR--------------- 209 + +L+YIHS GI HR++KP N+ +D V K+ DFG AK + R Sbjct: 125 ILEALSYIHSQGIIHRNLKPMNIFIDESRNV-KIGDFGLAKNVHRSLDILKLDSQNLPGS 183 Query: 210 GEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEI 269 + S I + Y A E++ G Y ID++S G + E++ +P +G+++ V I Sbjct: 184 SDNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMI-----YPFSTGMER-VNI 237 Query: 270 IKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARL 329 +K L + + E + + N + + + L+++ P R Sbjct: 238 LKKLRSVSIEFPPDFDDNKMKVE---------------------KKIIRLLIDHDPNKRP 276 Query: 330 TPLEACAHSFF 340 + Sbjct: 277 GARTLLNSGWL 287 >5UUU-A nrPDB Length = 547 Score = 197 bits (500), Expect = 1e-50, Method: Composition-based stats. Identities = 76/353 (21%), Positives = 132/353 (37%), Gaps = 60/353 (16%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIK-------KVLQDKRFKNRELQIMRKL--- 104 ++ ++IG G FG VY + D+G++ A+K K+ Q + E ++ + Sbjct: 199 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 258 Query: 105 DHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQ 164 D IV + Y F++ + L+ +LD + ++ ++ Y + Sbjct: 259 DCPFIVCMSYAFHTPDK------LSFILDLMNGGDLH---YHLSQHGVFSEADMRFYAAE 309 Query: 165 LFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRA 224 + L ++H+ + +RD+KP N+LLD V ++ D G A + +P+ S + + Y A Sbjct: 310 IILGLEHMHNRFVVYRDLKPANILLDEHGHV-RISDLGLACDFSKKKPHAS-VGTHGYMA 367 Query: 225 PELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREM 284 PE++ Y SS D +S GC+L +LL G F D+ EI ++ T E Sbjct: 368 PEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK-HEIDRMTLTMAVE----- 421 Query: 285 NPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARL-----TPLEACAHSF 339 PE +L LL+ RL E F Sbjct: 422 --------------------LPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPF 461 Query: 340 FDEL--------RDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARI 384 F L + P +P + A F L+ + Sbjct: 462 FRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQEL 514 >3PVW-A nrPDB Length = 695 Score = 196 bits (499), Expect = 1e-50, Method: Composition-based stats. Identities = 76/353 (21%), Positives = 132/353 (37%), Gaps = 60/353 (16%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIK-------KVLQDKRFKNRELQIMRKL--- 104 ++ ++IG G FG VY + D+G++ A+K K+ Q + E ++ + Sbjct: 190 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 249 Query: 105 DHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQ 164 D IV + Y F++ + L+ +LD + ++ ++ Y + Sbjct: 250 DCPFIVCMSYAFHTPDK------LSFILDLMNGGDLH---YHLSQHGVFSEADMRFYAAE 300 Query: 165 LFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRA 224 + L ++H+ + +RD+KP N+LLD V ++ D G A + +P+ S + + Y A Sbjct: 301 IILGLEHMHNRFVVYRDLKPANILLDEHGHV-RISDLGLACDFSKKKPHAS-VGTHGYMA 358 Query: 225 PELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREM 284 PE++ Y SS D +S GC+L +LL G F D+ EI ++ T E Sbjct: 359 PEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK-HEIDRMTLTMAVE----- 412 Query: 285 NPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARL-----TPLEACAHSF 339 PE +L LL+ RL E F Sbjct: 413 --------------------LPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPF 452 Query: 340 FDEL--------RDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARI 384 F L + P +P + A F L+ + Sbjct: 453 FRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQEL 505 >6NPU-A nrPDB Length = 298 Score = 196 bits (499), Expect = 1e-50, Method: Composition-based stats. Identities = 51/300 (17%), Positives = 112/300 (37%), Gaps = 47/300 (15%) Query: 42 ATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQD---KRFKNREL 98 +P + T +G G +G VY+ VA+K + +D +E Sbjct: 14 GSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEA 73 Query: 99 QIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVP-ETVYRVARHYSRAKQTLPVIY 157 +M+++ H N+V+L E ++ +++ + R +R Q + + Sbjct: 74 AVMKEIKHPNLVQLLGVCTR------EPPFYIITEFMTYGNLLDYLRECNR--QEVNAVV 125 Query: 158 VKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYI 217 + Q+ ++ Y+ HRD+ +N L+ + ++K+ DFG ++ L+ G+ ++ Sbjct: 126 LLYMATQISSAMEYLEKKNFIHRDLAARNCLVG-ENHLVKVADFGLSR-LMTGDTYTAHA 183 Query: 218 CSRY---YRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVL 273 +++ + APE + ++ DVW+ G +L E+ G +PG Sbjct: 184 GAKFPIKWTAPESL-AYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQ--------- 233 Query: 274 GTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLE 333 ++ + P + L ++ P+ R + E Sbjct: 234 -------------------VYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAE 274 >4XEY-B nrPDB Length = 408 Score = 196 bits (498), Expect = 2e-50, Method: Composition-based stats. Identities = 53/309 (17%), Positives = 115/309 (37%), Gaps = 47/309 (15%) Query: 33 DGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQD-- 90 +K T +P + T +G G +G VY+ VA+K + +D Sbjct: 104 KRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTM 163 Query: 91 -KRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVP-ETVYRVARHYSR 148 +E +M+++ H N+V+L E ++ +++ + R +R Sbjct: 164 EVEEFLKEAAVMKEIKHPNLVQLLGVCTR------EPPFYIITEFMTYGNLLDYLRECNR 217 Query: 149 AKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLV 208 Q + + + Q+ ++ Y+ HRD+ +N L+ + ++K+ DFG ++ L+ Sbjct: 218 --QEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVG-ENHLVKVADFGLSR-LM 273 Query: 209 RGEPNVSYICSRY---YRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVD 264 G+ ++ +++ + APE + ++ DVW+ G +L E+ G +PG Sbjct: 274 TGDTYTAHAGAKFPIKWTAPESL-AYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQ 332 Query: 265 QLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYT 324 ++ + P + L ++ Sbjct: 333 ----------------------------VYELLEKDYRMERPEGCPEKVYELMRACWQWN 364 Query: 325 PTARLTPLE 333 P+ R + E Sbjct: 365 PSDRPSFAE 373 >5GRN-A nrPDB Length = 356 Score = 196 bits (497), Expect = 2e-50, Method: Composition-based stats. Identities = 80/349 (22%), Positives = 126/349 (36%), Gaps = 62/349 (17%) Query: 18 QQPSAFGSMKVSRDKDGSKVTTVVATPGQGP-DRPQE---VSYTDTKVIGNGSFGVVYQA 73 Q+P +V + P Q P D E +V+G+G+FG V + Sbjct: 6 QKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEG 65 Query: 74 K-----LCDSGELVAIKKVL-----QDKRFKNRELQIMRKLD-HCNIVRLRYFFYSSGEK 122 VA+K + +K+ EL+IM L H NIV L SG Sbjct: 66 TAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGP- 124 Query: 123 KDEVYLNLVLDYVPETVYRVARHYSR-----------------------AKQTLPVIYVK 159 + ++ +Y H +R + L ++ + Sbjct: 125 -----IYIITEYCFYGDLVNYLHKNRDSFLSHKKKSMLDSEVKNLLSDDNSEGLTLLDLL 179 Query: 160 LYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICS 219 + YQ+ R + ++ S HRD+ +N+LL ++K+CDFG A+ ++ VS + Sbjct: 180 SFTYQVARGMEFLASKNCVHRDLAARNVLL-AQGKIVKICDFGLARDIMHDSNYVSKGST 238 Query: 220 RY---YRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGT 275 + APE IF YT+ DVWS G +L E+ G +PG IK Sbjct: 239 FLPVKWMAPESIFD-NLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIK---- 293 Query: 276 PTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIAL---CSRLL 321 R P++ + +I W P P L LL Sbjct: 294 ---SGYRMAKPDHATSEVYEIMVKCWNS--EPEKRPSFYHLSEIVENLL 337 >3UIU-A nrPDB Length = 306 Score = 196 bits (497), Expect = 2e-50, Method: Composition-based stats. Identities = 67/311 (21%), Positives = 114/311 (36%), Gaps = 59/311 (18%) Query: 49 DRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCN 108 D+ + + + ++IG+G FG V++AK G+ I++V + RE++ + KLDH N Sbjct: 7 DKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIRRVKYNNEKAEREVKALAKLDHVN 66 Query: 109 IVRLR----YFFYSSGEKKDEV-------------------YLNLVLDYVPETVYRVARH 145 IV F Y D + L + +++ + Sbjct: 67 IVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIE 126 Query: 146 YSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAK 205 R ++ L + Q+ + + YIHS + HRD+KP N+ L DT +K+ DFG Sbjct: 127 KRRGEK-LDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFL-VDTKQVKIGDFGLVT 184 Query: 206 QLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQ 265 L + Y +PE I + DY +D+++ G +LAELL Sbjct: 185 SLKNDGKRTRSKGTLRYMSPEQI-SSQDYGKEVDLYALGLILAELL-------------- 229 Query: 266 LVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTP 325 + T F+ + + + L +LL P Sbjct: 230 -------------------HVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKP 270 Query: 326 TARLTPLEACA 336 R E Sbjct: 271 EDRPNTSEILR 281 >3LLT-A nrPDB Length = 360 Score = 195 bits (496), Expect = 3e-50, Method: Composition-based stats. Identities = 71/330 (21%), Positives = 137/330 (41%), Gaps = 50/330 (15%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNR---ELQIMRKLDHCNIVRL 112 + + +G+G+FG V + D+ + A+K V K++ E I++K+ + +I Sbjct: 37 FLVIRKMGDGTFGRVLLCQHIDNKKYYAVKVVRNIKKYTRSAKIEADILKKIQNDDINNN 96 Query: 113 RYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYI 172 Y G+ ++ L+ + + ++Y + + +KLY ++ ++L Y+ Sbjct: 97 NIVKYH-GKFMYYDHMCLIFEPLGPSLYEIITR--NNYNGFHIEDIKLYCIEILKALNYL 153 Query: 173 HSFGICHRDIKPQNLLLD------------------------PDTAVLKLCDFGSAKQLV 208 + H D+KP+N+LLD + +KL DFG A Sbjct: 154 RKMSLTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTKSTGIKLIDFGCAT--F 211 Query: 209 RGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVE 268 + + + S I +R YRAPE+I + S D+WS GCVLAEL G +F ++ L Sbjct: 212 KSDYHGSIINTRQYRAPEVILNL-GWDVSSDMWSFGCVLAELYTGSLLFRTHEHMEHLAM 270 Query: 269 IIKVLGTPTREQIRE---------MNPNYTEFKFPQIKA--------HPWTKVFRPRTPP 311 + ++ + + E +N + + +P+ + +++ Sbjct: 271 MESIIQPIPKNMLYEATKTNGSKYVNKDELKLAWPENASSINSIKHVKKCLPLYKIIKHE 330 Query: 312 EAIALCSRLLEYTPTARLTPLEACAHSFFD 341 +L+ PT R +P E H F + Sbjct: 331 LFCDFLYSILQIDPTLRPSPAELLKHKFLE 360 >1JPA-A nrPDB Length = 312 Score = 195 bits (495), Expect = 3e-50, Method: Composition-based stats. Identities = 61/286 (21%), Positives = 108/286 (37%), Gaps = 35/286 (12%) Query: 57 TDTKVIGNGSFGVVYQAKLCDSGE---LVAIKKVLQDKRFKNR-----ELQIMRKLDHCN 108 +VIG G FG V L G+ VAIK + K R E IM + DH N Sbjct: 36 KIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPN 95 Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRS 168 ++ L S + ++ +++ + + VI + + + Sbjct: 96 VIHLEGVVTKSTP------VMIITEFMENGSLDSFLRQNDGQ--FTVIQLVGMLRGIAAG 147 Query: 169 LAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY------Y 222 + Y+ HRD+ +N+L++ + V K+ DFG ++ L + +Y + + Sbjct: 148 MKYLADMNYVHRDLAARNILVNSNL-VCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRW 206 Query: 223 RAPELIFGATDYTSSIDVWSAGCVLAE-LLLGQPIFPGDSGVDQLVEIIKVLGTPTREQI 281 APE I +TS+ DVWS G V+ E + G+ + + D + I + Sbjct: 207 TAPEAI-QYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAI--------EQDY 257 Query: 282 REMNPNYTEFKFPQIKAHPWTKVFRPR-TPPEAIALCSRLLEYTPT 326 R P Q+ W K R + + +++ P Sbjct: 258 RLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDKMIR-NPN 302 >4P5Q-A nrPDB Length = 361 Score = 195 bits (495), Expect = 3e-50, Method: Composition-based stats. Identities = 67/283 (23%), Positives = 110/283 (38%), Gaps = 33/283 (11%) Query: 57 TDTKVIGNGSFGVVYQAKLCDSGEL---VAIKKVLQDKRFKNR-----ELQIMRKLDHCN 108 + KV+G G FG V +L + VAIK + K R E IM + DH N Sbjct: 36 SIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPN 95 Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRS 168 I+RL S + +V +Y+ + VI + + + Sbjct: 96 IIRLEGVVTKSKP------VMIVTEYMENGSLDSFLR--KHDAQFTVIQLVGMLRGIASG 147 Query: 169 LAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRG-EPNVSYICSR---YYRA 224 + Y+ G HRD+ +N+L++ + V K+ DFG ++ L E + + + + Sbjct: 148 MKYLSDMGYVHRDLAARNILINSNL-VCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTS 206 Query: 225 PELIFGATDYTSSIDVWSAGCVLAE-LLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIRE 283 PE I +TS+ DVWS G VL E + G+ + S D + + E R Sbjct: 207 PEAI-AYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAV--------DEGYRL 257 Query: 284 MNPNYTEFKFPQIKAHPWTKVFRPR-TPPEAIALCSRLLEYTP 325 P Q+ W K R + +++ + L P Sbjct: 258 PPPMDCPAALYQLMLDCWQKDRNNRPKFEQIVSILDK-LIRNP 299 >2XYN-A nrPDB Length = 292 Score = 195 bits (495), Expect = 4e-50, Method: Composition-based stats. Identities = 56/285 (19%), Positives = 110/285 (38%), Gaps = 47/285 (16%) Query: 57 TDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQD---KRFKNRELQIMRKLDHCNIVRLR 113 T +G G +G VY VA+K + +D +E +M+++ H N+V+L Sbjct: 35 TMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLL 94 Query: 114 YFFYSSGEKKDEVYLNLVLDYVP-ETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYI 172 E +V +Y+P + R +R + + + + Q+ ++ Y+ Sbjct: 95 GVC------TLEPPFYIVTEYMPYGNLLDYLRECNR--EEVTAVVLLYMATQISSAMEYL 146 Query: 173 HSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY---YRAPELIF 229 HRD+ +N L+ + V+K+ DFG ++ L+ G+ ++ +++ + APE + Sbjct: 147 EKKNFIHRDLAARNCLVG-ENHVVKVADFGLSR-LMTGDTYTAHAGAKFPIKWTAPESL- 203 Query: 230 GATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNY 288 ++ DVW+ G +L E+ G +PG + K E Sbjct: 204 AYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEG-------- 255 Query: 289 TEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLE 333 PP+ L +++P R + E Sbjct: 256 --------------------CPPKVYELMRACWKWSPADRPSFAE 280 >3IO7-A nrPDB Length = 313 Score = 195 bits (495), Expect = 4e-50, Method: Composition-based stats. Identities = 69/313 (22%), Positives = 132/313 (42%), Gaps = 44/313 (14%) Query: 50 RPQEVSYTDTKVIGNGSFGVVYQAKLC----DSGELVAIKKVLQDKRF----KNRELQIM 101 + +E + +G G+FG V + ++GE+VA+KK+ RE++I+ Sbjct: 24 QFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEIL 83 Query: 102 RKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLY 161 + L H NIV+ + YS+G + L L+++Y+P R + + K+ + I + Y Sbjct: 84 KSLQHDNIVKYKGVCYSAGRRN----LKLIMEYLPYGSLR--DYLQKHKERIDHIKLLQY 137 Query: 162 MYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYI---- 217 Q+ + + Y+ + HRD+ +N+L++ + V K+ DFG K L + + Sbjct: 138 TSQICKGMEYLGTKRYIHRDLATRNILVENENRV-KIGDFGLTKVLPQDKEYYKVKEPGE 196 Query: 218 CSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPT 277 ++ APE + + ++ + DVWS G VL EL I+ +P Sbjct: 197 SPIFWYAPESLT-ESKFSVASDVWSFGVVLYELFT----------------YIEKSKSPP 239 Query: 278 REQIREMNPNYTE----FKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLE 333 E +R + + F ++ + P E + + R + + Sbjct: 240 AEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRD 299 Query: 334 -ACAHSFFDELRD 345 A D++RD Sbjct: 300 LALR---VDQIRD 309 >2FO0-A nrPDB Length = 495 Score = 195 bits (495), Expect = 4e-50, Method: Composition-based stats. Identities = 52/309 (16%), Positives = 115/309 (37%), Gaps = 47/309 (15%) Query: 33 DGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQD-- 90 +K T +P + T +G G +G VY+ VA+K + +D Sbjct: 196 KRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTM 255 Query: 91 -KRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVP-ETVYRVARHYSR 148 +E +M+++ H N+V+L E ++ +++ + R +R Sbjct: 256 EVEEFLKEAAVMKEIKHPNLVQLLGVC------TREPPFYIITEFMTYGNLLDYLRECNR 309 Query: 149 AKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLV 208 Q + + + Q+ ++ Y+ HR++ +N L+ + ++K+ DFG ++ L+ Sbjct: 310 --QEVNAVVLLYMATQISSAMEYLEKKNFIHRNLAARNCLVG-ENHLVKVADFGLSR-LM 365 Query: 209 RGEPNVSYICSRY---YRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVD 264 G+ ++ +++ + APE + ++ DVW+ G +L E+ G +PG Sbjct: 366 TGDTYTAHAGAKFPIKWTAPESL-AYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQ 424 Query: 265 QLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYT 324 ++ + P + L ++ Sbjct: 425 ----------------------------VYELLEKDYRMERPEGCPEKVYELMRACWQWN 456 Query: 325 PTARLTPLE 333 P+ R + E Sbjct: 457 PSDRPSFAE 465 >4R7H-A nrPDB Length = 343 Score = 194 bits (494), Expect = 5e-50, Method: Composition-based stats. Identities = 74/330 (22%), Positives = 126/330 (38%), Gaps = 56/330 (16%) Query: 18 QQPSAFGSMKVSRDKDGSKVTTVVATPGQGP-DRPQEV---SYTDTKVIGNGSFGVVYQA 73 Q+P K+ +G+ T + P Q P + E + K +G G+FG V +A Sbjct: 12 QKPKYQVRWKIIESYEGNSYTFI--DPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEA 69 Query: 74 KLCDSGEL-----VAIKKVLQ-----DKRFKNRELQIMRKL-DHCNIVRLRYFFYSSGEK 122 G+ VA+K + +K EL+IM L H NIV L G Sbjct: 70 TAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGP- 128 Query: 123 KDEVYLNLVLDYVP-ETVYRVARHYSRAK-------------------QTLPVIYVKLYM 162 + ++ +Y + R + A + L + + + Sbjct: 129 -----VLVITEYCTYGDLLNFLRRKAEAMLGPSLSPGQDPEGLDKEDGRPLELRDLLHFS 183 Query: 163 YQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY- 221 Q+ + +A++ S HRD+ +N+LL + V K+ DFG A+ ++ + +R Sbjct: 184 SQVAQGMAFLASKNCIHRDVAARNVLLT-NGHVAKIGDFGLARDIMNDSNYIVKGNARLP 242 Query: 222 --YRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTR 278 + APE IF + YT DVWS G +L E+ G +PG + +++K Sbjct: 243 VKWMAPESIFDSV-YTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVK------- 294 Query: 279 EQIREMNPNYTEFKFPQIKAHPWTKVFRPR 308 + + P + I W R Sbjct: 295 DGYQMAQPAFAPKNIYSIMQACWALEPTHR 324 >4X7Q-B nrPDB Length = 312 Score = 194 bits (493), Expect = 6e-50, Method: Composition-based stats. Identities = 74/329 (22%), Positives = 119/329 (36%), Gaps = 59/329 (17%) Query: 51 PQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKV----------LQDKRFKNRELQI 100 E Y ++G G FG V+ VAIK + L D E+ + Sbjct: 28 AFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVAL 87 Query: 101 MRKLD----HCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVI 156 + K+ H ++RL +F E ++ L L + ++ Y K L Sbjct: 88 LWKVGAGGGHPGVIRLLDWF----ETQEGFMLVLERPLPAQDLFD----YITEKGPLGEG 139 Query: 157 YVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSY 216 + + Q+ ++ + HS G+ HRDIK +N+L+D KL DFG + L+ EP + Sbjct: 140 PSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFG-SGALLHDEPYTDF 198 Query: 217 ICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTP 276 +R Y PE I + VWS G +L +++ G F D EI++ Sbjct: 199 DGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQ------EILEA---- 248 Query: 277 TREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACA 336 E FP P+ AL R L P++R + E Sbjct: 249 -------------ELHFP------------AHVSPDCCALIRRCLAPKPSSRPSLEEILL 283 Query: 337 HSFFD-ELRDPNVKLPNGRDTPALFNFTT 364 + D + G P ++ Sbjct: 284 DPWMQTPAEDVPLNPSKGGPAPLAWSLLP 312 >5X5O-A nrPDB Length = 310 Score = 194 bits (493), Expect = 6e-50, Method: Composition-based stats. Identities = 61/262 (23%), Positives = 119/262 (45%), Gaps = 25/262 (9%) Query: 63 GNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEK 122 G GSFG VY+AK + VA+KK+L+ +E +I+ L H NI++ Sbjct: 24 GGGSFGSVYRAKWISQDKEVAVKKLLK----IEKEAEILSVLSHRNIIQFYGVIL----- 74 Query: 123 KDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSF---GICH 179 + +V +Y + +R+++ + + ++ + + + + Y+H + H Sbjct: 75 -EPPNYGIVTEYASLGSLYDYINSNRSEE-MDMDHIMTWATDVAKGMHYLHMEAPVKVIH 132 Query: 180 RDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSID 239 RD+K +N+++ D VLK+CDFG A + ++S + + + APE+I + + + D Sbjct: 133 RDLKSRNVVIAAD-GVLKICDFG-ASRFHNHTTHMSLVGTFPWMAPEVI-QSLPVSETCD 189 Query: 240 VWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH 299 +S G VL E+L + F G G ++V + R P+ F ++ Sbjct: 190 TYSYGVVLWEMLTREVPFKGLEG-------LQVAWLVVEKNERLTIPSSCPRSFAELLHQ 242 Query: 300 PWTKVFRPRTP-PEAIALCSRL 320 W + R + I++ + Sbjct: 243 CWEADAKKRPSFKQIISILESM 264 >4PDO-A nrPDB Length = 299 Score = 194 bits (492), Expect = 9e-50, Method: Composition-based stats. Identities = 64/281 (22%), Positives = 111/281 (39%), Gaps = 33/281 (11%) Query: 57 TDTKVIGNGSFGVVYQAKLC-DSGEL---VAIKKVLQDKRFKNR-----ELQIMRKLDHC 107 T KVIG G FG VY+ L SG+ VAIK + K R E IM + H Sbjct: 37 TRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFSHH 96 Query: 108 NIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFR 167 NI+RL + ++ +Y+ + V+ + + + Sbjct: 97 NIIRLEGVI------SKYKPMMIITEYMENGALD--KFLREKDGEFSVLQLVGMLRGIAA 148 Query: 168 SLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRG-EPNVSYICSR---YYR 223 + Y+ + HRD+ +N+L++ + V K+ DFG ++ L E + + + Sbjct: 149 GMKYLANMNYVHRDLAARNILVNSNL-VCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWT 207 Query: 224 APELIFGATDYTSSIDVWSAGCVLAE-LLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIR 282 APE I +TS+ DVWS G V+ E + G+ + S + + I + R Sbjct: 208 APEAI-SYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAI--------NDGFR 258 Query: 283 EMNPNYTEFKFPQIKAHPWTKVFRPR-TPPEAIALCSRLLE 322 P Q+ W + R + +++ +L+ Sbjct: 259 LPTPMDCPSAIYQLMMQCWQQERARRPKFADIVSILDKLIR 299 >2X7G-A nrPDB Length = 389 Score = 193 bits (491), Expect = 1e-49, Method: Composition-based stats. Identities = 79/393 (20%), Positives = 142/393 (36%), Gaps = 89/393 (22%) Query: 29 SRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVL 88 +D + P + D Y + +G G F V+ VA+K V Sbjct: 7 EEQEDPADYCKGGYHPVKIGD-LFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVK 65 Query: 89 QDKRFKN---RELQIMRKLDH-----CN---IVRLRYFFYSSGEKKDEVYLNLVLDYVPE 137 + + E+++++ + N +V+L F SG + +++ +V + + Sbjct: 66 SAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISG--MNGIHVCMVFEVLGH 123 Query: 138 TVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSF-GICHRDIKPQNLLL------- 189 + + Q LPV VK + Q+ + L Y+HS I H DIKP+N+L+ Sbjct: 124 HLLKWI--IKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYV 181 Query: 190 ---------------------------------------DPDTAVLKLCDFGSAKQLVRG 210 + D +K+ D G+A + + Sbjct: 182 RRMAAEATEWQKAGAPPPSGSAVSTAPAADLLVNPLDPRNADKIRVKIADLGNACWVHK- 240 Query: 211 EPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSG------VD 264 I +R YR+ E++ GA Y++ D+WS C+ EL G +F SG D Sbjct: 241 -HFTEDIQTRQYRSIEVLIGA-GYSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDED 298 Query: 265 QLVEIIKVLGTPTREQIREMNPNYTEFKFPQ-------IKAHPWTKV--------FRPRT 309 + II++LG+ R ++ Y+ F + K PW+ + Sbjct: 299 HIAHIIELLGSIPRHF--ALSGKYSREFFNRRGELRHITKLKPWSLFDVLVEKYGWPHED 356 Query: 310 PPEAIALCSRLLEYTPTARLTPLEACAHSFFDE 342 + +LE P R + E H + + Sbjct: 357 AAQFTDFLIPMLEMVPEKRASAGECLRHPWLNS 389 >5GNK-A nrPDB Length = 297 Score = 193 bits (491), Expect = 1e-49, Method: Composition-based stats. Identities = 66/307 (21%), Positives = 117/307 (38%), Gaps = 43/307 (14%) Query: 42 ATPGQGPDRP-----QEVSYTDTKVIGNGSFGVVYQAKLCDSGELV----AIKKVL---- 88 A G+ P++ +E + KV+G+G+FG VY+ GE V AIK++ Sbjct: 2 AMGGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATS 61 Query: 89 -QDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYS 147 + + E +M +D+ ++ RL +S + L++ +P + + Sbjct: 62 PKANKEILDEAYVMASVDNPHVCRLLGICLTST-------VQLIMQLMPFGC--LLDYVR 112 Query: 148 RAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQL 207 K + Y+ + Q+ + + Y+ + HRD+ +N+L+ V K+ DFG AK L Sbjct: 113 EHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHV-KITDFGLAKLL 171 Query: 208 VRGEPNVSYICSRY---YRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGV 263 E + + A E I YT DVWS G + EL+ G + G Sbjct: 172 GAEEKEYHAEGGKVPIKWMALESIL-HRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPAS 230 Query: 264 DQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALC---SRL 320 + + + + R P I W + P+ L S++ Sbjct: 231 E--------ISSILEKGERLPQPPICTIDVYMIMVKCWM--IDADSRPKFRELIIEFSKM 280 Query: 321 LEYTPTA 327 P Sbjct: 281 -ARDPQR 286 >3PPZ-A nrPDB Length = 309 Score = 193 bits (490), Expect = 1e-49, Method: Composition-based stats. Identities = 72/291 (24%), Positives = 117/291 (40%), Gaps = 28/291 (9%) Query: 42 ATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDK------RFKN 95 A G D P + IG GSFG V++A+ G VA+K +++ Sbjct: 26 AMDGDDMDIPW-CDLNIKEKIGAGSFGTVHRAEWH--GSDVAVKILMEQDFHAERVNEFL 82 Query: 96 RELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPV 155 RE+ IM++L H NIV G L++V +Y+ H S A++ L Sbjct: 83 REVAIMKRLRHPNIV------LFMGAVTQPPNLSIVTEYLSRGSLYRLLHKSGAREQLDE 136 Query: 156 IYVKLYMYQLFRSLAYIHSFG--ICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGE-P 212 Y + + + Y+H+ I HRD+K NLL+D V K+CDFG ++ Sbjct: 137 RRRLSMAYDVAKGMNYLHNRNPPIVHRDLKSPNLLVDKKYTV-KVCDFGLSRLKASTFLS 195 Query: 213 NVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKV 272 + S + + APE++ DV+S G +L EL Q + + +++ Sbjct: 196 SKSAAGTPEWMAPEVLRDEPS-NEKSDVYSFGVILWELATLQQPWGNLNP----AQVVAA 250 Query: 273 LGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTP-PEAIALCSRLLE 322 +G + R P + I WT R + L L++ Sbjct: 251 VGFKCK---RLEIPRNLNPQVAAIIEGCWTNEPWKRPSFATIMDLLRPLIK 298 >3TT0-A nrPDB Length = 382 Score = 192 bits (489), Expect = 2e-49, Method: Composition-based stats. Identities = 73/312 (23%), Positives = 122/312 (39%), Gaps = 52/312 (16%) Query: 43 TPGQGPDRPQ----EVSYTDTKVIGNGSFGVVYQA------KLCDSGE-LVAIKKVLQDK 91 + + P+ P+ K +G G+FG V A K + VA+K + D Sbjct: 54 SEYELPEDPRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDA 113 Query: 92 RFKN-----RELQIMRKL-DHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARH 145 K+ E+++M+ + H NI+ L G L ++++Y + R Sbjct: 114 TEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGP------LYVIVEYASKGNLREYLQ 167 Query: 146 YSRA-------------KQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPD 192 R ++ L + YQ+ R + Y+ S HRD+ +N+L+ D Sbjct: 168 ARRPPGLEYSYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTED 227 Query: 193 TAVLKLCDFGSAKQLVRGEPNVSYICSRY---YRAPELIFGATDYTSSIDVWSAGCVLAE 249 V+K+ DFG A+ + + R + APE +F YT DVWS G +L E Sbjct: 228 N-VMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRI-YTHQSDVWSFGVLLWE 285 Query: 250 LLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPR 308 + G +PG V++L +++K E R P+ + + W V P Sbjct: 286 IFTLGGSPYPGV-PVEELFKLLK-------EGHRMDKPSNCTNELYMMMRDCWHAV--PS 335 Query: 309 TPPEAIALCSRL 320 P L L Sbjct: 336 QRPTFKQLVEDL 347 >2DQ7-X nrPDB Length = 283 Score = 192 bits (489), Expect = 2e-49, Method: Composition-based stats. Identities = 68/302 (22%), Positives = 116/302 (38%), Gaps = 50/302 (16%) Query: 49 DRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVL---QDKRFKNRELQIMRKLD 105 + P+E S K +GNG FG V+ + VAIK + E QIM+KL Sbjct: 5 EIPRE-SLQLIKRLGNGQFGEVWMGTW-NGNTKVAIKTLKPGTMSPESFLEEAQIMKKLK 62 Query: 106 HCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQL 165 H +V+L E + +V +Y+ + + L + + Q+ Sbjct: 63 HDKLVQLYAVVS-------EEPIYIVTEYMNKGSLLDFLKDGEGR-ALKLPNLVDMAAQV 114 Query: 166 FRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY---Y 222 +AYI HRD++ N+L+ + + K+ DFG A+ L+ + +++ + Sbjct: 115 AAGMAYIERMNYIHRDLRSANILVG-NGLICKIADFGLAR-LIEDNEYTARQGAKFPIKW 172 Query: 223 RAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQI 281 APE +T DVWS G +L EL+ G+ +PG + + L ++ + P Sbjct: 173 TAPEAAL-YGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPC---- 227 Query: 282 REMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFD 341 P ++ H W + P R T E SF + Sbjct: 228 ----PQDCPISLHELMIHCW--------------------KKDPEERPT-FEYLQ-SFLE 261 Query: 342 EL 343 + Sbjct: 262 DY 263 >4E93-A nrPDB Length = 377 Score = 192 bits (488), Expect = 2e-49, Method: Composition-based stats. Identities = 65/305 (21%), Positives = 103/305 (33%), Gaps = 53/305 (17%) Query: 47 GPDRPQEVSYTDT---KVIGNGSFGVVYQAKLCDSGELVAIKKVLQD-----KRFKNREL 98 P +++ D + IG G+FG V+ +L LVA+K + K +E Sbjct: 104 VPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEA 163 Query: 99 QIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYV 158 +I+++ H NIVRL + + +V++ V L V + Sbjct: 164 RILKQYSHPNIVRLIGVC------TQKQPIYIVMELVQGG--DFLTFLRTEGARLRVKTL 215 Query: 159 KLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVS--- 215 + + Y+ S HRD+ +N L+ VLK+ DFG +++ G S Sbjct: 216 LQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKN-VLKISDFGMSREEADGVYAASGGL 274 Query: 216 YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLG 274 + APE + Y+S DVWS G +L E G +P S + K Sbjct: 275 RQVPVKWTAPEAL-NYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGR 333 Query: 275 TPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARL---TP 331 P E P L + Y P R T Sbjct: 334 LPCPEL----------------------------CPDAVFRLMEQCWAYEPGQRPSFSTI 365 Query: 332 LEACA 336 + Sbjct: 366 YQELQ 370 >2H8H-A nrPDB Length = 535 Score = 192 bits (487), Expect = 3e-49, Method: Composition-based stats. Identities = 62/302 (20%), Positives = 108/302 (35%), Gaps = 50/302 (16%) Query: 61 VIGNGSFGVVYQAKLCDSGELVAIKKVL---QDKRFKNRELQIMRKLDHCNIVRLRYFFY 117 +G G FG V+ + VAIK + +E Q+M+KL H +V+L Sbjct: 274 KLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVS 332 Query: 118 SSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGI 177 E + +V +Y+ + + L + + Q+ +AY+ Sbjct: 333 -------EEPIYIVTEYMSKGSLLDFLK-GETGKYLRLPQLVDMAAQIASGMAYVERMNY 384 Query: 178 CHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY---YRAPELIFGATDY 234 HRD++ N+L+ + V K+ DFG A+ L+ + +++ + APE + Sbjct: 385 VHRDLRAANILVGENL-VCKVADFGLAR-LIEDNEYTARQGAKFPIKWTAPEAAL-YGRF 441 Query: 235 TSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKF 293 T DVWS G +L EL G+ +PG + L ++ + P Sbjct: 442 TIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCP--------------- 486 Query: 294 PQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPL--EACAHSFFDELRDPNVKLP 351 P P L + P R T +A +F +P + Sbjct: 487 -------------PECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTS-TEPQYQPG 532 Query: 352 NG 353 Sbjct: 533 EN 534 >3QUP-A nrPDB Length = 323 Score = 191 bits (486), Expect = 4e-49, Method: Composition-based stats. Identities = 60/294 (20%), Positives = 105/294 (35%), Gaps = 46/294 (15%) Query: 53 EVSYTDTKVIGNGSFGVVYQAKLCDSG---ELVAIKKVL------QDKRFKNRELQIMRK 103 E +T +++G G FG V +A+L VA+K + D RE M++ Sbjct: 22 EQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKE 81 Query: 104 LDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYR---VARHYSRAKQTLPVIYVKL 160 DH ++ +L S K ++L ++ +A LP+ + Sbjct: 82 FDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLVR 141 Query: 161 YMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSR 220 +M + + Y+ S HRD+ +N +L D V + DFG ++++ G+ S+ Sbjct: 142 FMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVC-VADFGLSRKIYSGDYYRQGCASK 200 Query: 221 Y---YRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTP 276 + A E + YT DVW+ G + E++ GQ + G + +I Sbjct: 201 LPVKWLALESLAD-NLYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIG----- 254 Query: 277 TREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLT 330 R P P E L + P R + Sbjct: 255 ---GNRLKQP--------------------PECMEEVYDLMYQCWSADPKQRPS 285 >3GQL-A nrPDB Length = 326 Score = 191 bits (486), Expect = 5e-49, Method: Composition-based stats. Identities = 73/312 (23%), Positives = 122/312 (39%), Gaps = 52/312 (16%) Query: 43 TPGQGPDRPQ----EVSYTDTKVIGNGSFGVVYQA------KLCDSGE-LVAIKKVLQDK 91 + + P+ P+ K +G G+FG V A K + VA+K + D Sbjct: 13 SEYELPEDPRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDA 72 Query: 92 RFKN-----RELQIMRKL-DHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARH 145 K+ E+++M+ + H NI+ L G L ++++Y + R Sbjct: 73 TEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGP------LYVIVEYASKGNLREYLQ 126 Query: 146 YSRA-------------KQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPD 192 R ++ L + YQ+ R + Y+ S HRD+ +N+L+ D Sbjct: 127 ARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTED 186 Query: 193 TAVLKLCDFGSAKQLVRGEPNVSYICSRY---YRAPELIFGATDYTSSIDVWSAGCVLAE 249 V+K+ DFG A+ + + R + APE +F YT DVWS G +L E Sbjct: 187 N-VMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRI-YTHQSDVWSFGVLLWE 244 Query: 250 LLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPR 308 + G +PG V++L +++K E R P+ + + W V P Sbjct: 245 IFTLGGSPYPGV-PVEELFKLLK-------EGHRMDKPSNCTNELYMMMRDCWHAV--PS 294 Query: 309 TPPEAIALCSRL 320 P L L Sbjct: 295 QRPTFKQLVEDL 306 >5SYS-A nrPDB Length = 286 Score = 191 bits (485), Expect = 5e-49, Method: Composition-based stats. Identities = 61/302 (20%), Positives = 107/302 (35%), Gaps = 50/302 (16%) Query: 61 VIGNGSFGVVYQAKLCDSGELVAIKKVL---QDKRFKNRELQIMRKLDHCNIVRLRYFFY 117 +G G FG + + VAIK + +E Q+M+KL H +V+L Sbjct: 25 KLGQGCFGECWMGTWNGTTR-VAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVS 83 Query: 118 SSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGI 177 E + +V +Y+ + + L + + Q+ +AY+ Sbjct: 84 -------EEPIYIVTEYMSKGSLLDFLK-GEMGKYLRLPQLVDMAAQIASGMAYVERMNY 135 Query: 178 CHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY---YRAPELIFGATDY 234 HRD++ N+L+ + V K+ DFG A+ L+ + +++ + APE + Sbjct: 136 VHRDLRAANILVGENL-VCKVADFGLAR-LIEDNEYTARQGAKFPIKWTAPEAAL-YGRF 192 Query: 235 TSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKF 293 T DVWS G +L EL G+ +PG + L ++ + P Sbjct: 193 TIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCP--------------- 237 Query: 294 PQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPL--EACAHSFFDELRDPNVKLP 351 P P L + P R T +A +F +P + Sbjct: 238 -------------PECPESLHDLMCQCWRKDPEERPTFEYLQAFLEDYFTS-TEPQYQPG 283 Query: 352 NG 353 Sbjct: 284 EN 285 >3CJF-A nrPDB Length = 309 Score = 191 bits (485), Expect = 6e-49, Method: Composition-based stats. Identities = 72/304 (23%), Positives = 118/304 (38%), Gaps = 58/304 (19%) Query: 58 DTKVIGNGSFGVVYQA----KLC-DSGELVAIKKVLQ-----DKRFKNRELQIMRKLDHC 107 K +G G+FG V +A + VA+K + + + R EL+I+ + H Sbjct: 31 LGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHH 90 Query: 108 -NIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRA---------KQTLPVIY 157 N+V L G L +++++ R K L + + Sbjct: 91 LNVVNLLGACTKPG-----GPLMVIVEFCKFGNLSTYLRSKRNEFVPYKDLYKDFLTLEH 145 Query: 158 VKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYI 217 + Y +Q+ + + ++ S HRD+ +N+LL + V+K+CDFG A+ + + V Sbjct: 146 LICYSFQVAKGMEFLASRKCIHRDLAARNILL-SEKNVVKICDFGLARDIYKDPDYVRKG 204 Query: 218 CSRY---YRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVL 273 +R + APE IF YT DVWS G +L E+ G +PG V+I + Sbjct: 205 DARLPLKWMAPETIFDRV-YTIQSDVWSFGVLLWEIFSLGASPYPG-------VKIDEEF 256 Query: 274 GTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLE 333 +E R P+YT + Q W P+ R T E Sbjct: 257 CRRLKEGTRMRAPDYTTPEMYQTMLDCWHG--------------------EPSQRPTFSE 296 Query: 334 ACAH 337 H Sbjct: 297 LVEH 300 >3LZB-A nrPDB Length = 327 Score = 191 bits (484), Expect = 6e-49, Method: Composition-based stats. Identities = 65/304 (21%), Positives = 115/304 (37%), Gaps = 43/304 (14%) Query: 45 GQGPDRP-----QEVSYTDTKVIGNGSFGVVYQAKLCDSGELV----AIKKVL-----QD 90 G+ P++ +E + KV+G+G+FG VY+ GE V AIK++ + Sbjct: 1 GEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKA 60 Query: 91 KRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAK 150 + E +M +D+ ++ RL +S + L+ +P + + K Sbjct: 61 NKEILDEAYVMASVDNPHVCRLLGICLTST-------VQLITQLMPFGC--LLDYVREHK 111 Query: 151 QTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRG 210 + Y+ + Q+ + + Y+ + HRD+ +N+L+ V K+ DFG AK L Sbjct: 112 DNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHV-KITDFGLAKLLGAE 170 Query: 211 EPNVSYICSRY---YRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQL 266 E + + A E I YT DVWS G + EL+ G + G + Sbjct: 171 EKEYHAEGGKVPIKWMALESIL-HRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASE-- 227 Query: 267 VEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALC---SRLLEY 323 + + + R P I W + P+ L S++ Sbjct: 228 ------ISSILEKGERLPQPPICTIDVYMIMRKCWM--IDADSRPKFRELIIEFSKM-AR 278 Query: 324 TPTA 327 P Sbjct: 279 DPQR 282 >1S9I-A nrPDB Length = 354 Score = 191 bits (484), Expect = 6e-49, Method: Composition-based stats. Identities = 73/328 (22%), Positives = 124/328 (37%), Gaps = 39/328 (11%) Query: 52 QEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKR-----FKNRELQIMRKLDH 106 ++ + +G G+ GVV + + SG ++A K + + + RELQ++ + + Sbjct: 14 KDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNS 73 Query: 107 CNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLF 166 IV FYS GE +++ ++++ + + +P + + Sbjct: 74 PYIVGFYGAFYSDGE------ISICMEHMDGGSLD---QVLKEAKRIPEEILGKVSIAVL 124 Query: 167 RSLAYI-HSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAP 225 R LAY+ I HRD+KP N+L++ +KLCDFG + QL+ N S++ +R Y AP Sbjct: 125 RGLAYLREKHQIMHRDVKPSNILVNSRGE-IKLCDFGVSGQLIDSMAN-SFVGTRSYMAP 182 Query: 226 ELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMN 285 E + G T Y+ D+WS G L EL +G+ P + L I E Sbjct: 183 ERLQG-THYSVQSDIWSMGLSLVELAVGRYPIPPPDAKE-LEAIFGRPVVDGEEGEPHSI 240 Query: 286 PNYTEFKFPQIKAH--------------------PWTKVFRPRTPPEAIALCSRLLEYTP 325 + H P K+ P+ ++ L P Sbjct: 241 SPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNP 300 Query: 326 TARLTPLEACAHSFFDELRDPNVKLPNG 353 R H+F V Sbjct: 301 AERADLKMLTNHTFIKRSEVEEVDFAGW 328 >6F3F-A nrPDB Length = 455 Score = 191 bits (484), Expect = 8e-49, Method: Composition-based stats. Identities = 62/302 (20%), Positives = 108/302 (35%), Gaps = 50/302 (16%) Query: 61 VIGNGSFGVVYQAKLCDSGELVAIKKVL---QDKRFKNRELQIMRKLDHCNIVRLRYFFY 117 +G G FG V+ + VAIK + +E Q+M+KL H +V+L Sbjct: 194 KLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVS 252 Query: 118 SSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGI 177 E + +V +Y+ + + L + + Q+ +AY+ Sbjct: 253 -------EEPIYIVTEYMNKGSLLDFLK-GETGKYLRLPQLVDMSAQIASGMAYVERMNY 304 Query: 178 CHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY---YRAPELIFGATDY 234 HRD++ N+L+ + V K+ DFG A+ L+ + +++ + APE + Sbjct: 305 VHRDLRAANILVGENL-VCKVADFGLAR-LIEDNEYTARQGAKFPIKWTAPEAAL-YGRF 361 Query: 235 TSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKF 293 T DVWS G +L EL G+ +PG + L ++ + P Sbjct: 362 TIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCP--------------- 406 Query: 294 PQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPL--EACAHSFFDELRDPNVKLP 351 P P L + P R T +A +F +P + Sbjct: 407 -------------PECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTS-TEPQYQPG 452 Query: 352 NG 353 Sbjct: 453 EN 454 >4EBW-A nrPDB Length = 304 Score = 190 bits (483), Expect = 1e-48, Method: Composition-based stats. Identities = 68/284 (23%), Positives = 106/284 (37%), Gaps = 50/284 (17%) Query: 57 TDTKVIGNGSFGVVYQAKLC---DSGELVAIKKVLQ-----DKRFKNRELQIMRKLDHCN 108 + IG G FG V+Q + VAIK + +E MR+ DH + Sbjct: 41 ELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPH 100 Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRS 168 IV+L E + ++++ R + +L + + LY YQL + Sbjct: 101 IVKLIGVI-------TENPVWIIMELCTLGELRSFLQVRKY--SLDLASLILYAYQLSTA 151 Query: 169 LAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY--YRAPE 226 LAY+ S HRDI +N+L+ + V KL DFG ++ + + + APE Sbjct: 152 LAYLESKRFVHRDIAARNVLVSSNDCV-KLGDFGLSRYMEDSTYYKASKGKLPIKWMAPE 210 Query: 227 LIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMN 285 I +TS+ DVW G + E+L+ G F G D + I P Sbjct: 211 SI-NFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLP--------- 260 Query: 286 PNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARL 329 P PP +L ++ Y P+ R Sbjct: 261 -------------------MPPNCPPTLYSLMTKCWAYDPSRRP 285 >4HVI-A nrPDB Length = 314 Score = 190 bits (482), Expect = 1e-48, Method: Composition-based stats. Identities = 74/300 (24%), Positives = 119/300 (39%), Gaps = 39/300 (13%) Query: 46 QGPDRPQEVSYTDTKVIGNGSFGVVYQAKLC----DSGELVAIKKVLQD----KRFKNRE 97 Q P +E +G G+FG V + ++G LVA+K++ +R RE Sbjct: 2 QDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQRE 61 Query: 98 LQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIY 157 +QI++ L IV+ R Y G + L LV++Y+P R RA+ L Sbjct: 62 IQILKALHSDFIVKYRGVSYGPGRQS----LRLVMEYLPSGCLRDFLQRHRAR--LDASR 115 Query: 158 VKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSY- 216 + LY Q+ + + Y+ S HRD+ +N+L++ + V K+ DFG AK L + Sbjct: 116 LLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHV-KIADFGLAKLLPLDKDYYVVR 174 Query: 217 ---ICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVL 273 ++ APE + ++ DVWS G VL EL + S Sbjct: 175 EPGQSPIFWYAPESLSDNI-FSRQSDVWSFGVVLYELFT----YCDKS------------ 217 Query: 274 GTPTREQIREMNPNYTEFKFPQIKAHPWTKVF---RPRTPPEAIALCSRLLEYTPTARLT 330 +P+ E +R M ++ P P E L +P R + Sbjct: 218 CSPSAEFLRMMGSERDVPALSRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPS 277 >4K33-A nrPDB Length = 325 Score = 190 bits (482), Expect = 1e-48, Method: Composition-based stats. Identities = 74/313 (23%), Positives = 119/313 (38%), Gaps = 51/313 (16%) Query: 38 TTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGE-------LVAIKKVLQD 90 + A P R + T K +G G+FG V A+ + VA+K + D Sbjct: 23 LELPADPKWELSRARL---TLGKPLGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDD 79 Query: 91 KRFKN-----RELQIMRKL-DHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVAR 144 K+ E+++M+ + H NI+ L G L ++++Y + R Sbjct: 80 ATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGP------LYVLVEYAAKGNLREFL 133 Query: 145 HYSRA-------------KQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDP 191 R ++ L + YQ+ R + Y+ S HRD+ +N+L+ Sbjct: 134 RARRPPGLDYSFDTSKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTE 193 Query: 192 DTAVLKLCDFGSAKQLVRGEPNVSYICSRY---YRAPELIFGATDYTSSIDVWSAGCVLA 248 D V+K+ DFG A+ + + R + APE +F YT DVWS G +L Sbjct: 194 DN-VMKIADFGLARDVHNLDYYKETTNGRLPVKWMAPEALFDRV-YTHQSDVWSFGVLLW 251 Query: 249 ELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRP 307 E+ G +PG V++L +++K E R P I W P Sbjct: 252 EIFTLGGSPYPGI-PVEELFKLLK-------EGHRMDKPANCTHDLYMIMRECWHA--AP 301 Query: 308 RTPPEAIALCSRL 320 P L L Sbjct: 302 SQRPTFKQLVEDL 314 >2PSQ-A nrPDB Length = 370 Score = 190 bits (482), Expect = 1e-48, Method: Composition-based stats. Identities = 77/341 (22%), Positives = 132/341 (38%), Gaps = 57/341 (16%) Query: 20 PSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQ----EVSYTDTKVIGNGSFGVVYQAK- 74 P + ++S D + V + + P+ P+ T K +G G FG V A+ Sbjct: 45 PLVRITTRLSSTADTPMLAGV--SEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEA 102 Query: 75 ---LCDSGEL---VAIKKVLQDKRFKN-----RELQIMRKL-DHCNIVRLRYFFYSSGEK 122 D + VA+K + D K+ E+++M+ + H NI+ L G Sbjct: 103 VGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGP- 161 Query: 123 KDEVYLNLVLDYVPETVYRVARHYSRA-------------KQTLPVIYVKLYMYQLFRSL 169 L ++++Y + R R ++ + + YQL R + Sbjct: 162 -----LYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGM 216 Query: 170 AYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY---YRAPE 226 Y+ S HRD+ +N+L+ + V+K+ DFG A+ + + R + APE Sbjct: 217 EYLASQKCIHRDLAARNVLVTENN-VMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPE 275 Query: 227 LIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMN 285 +F YT DVWS G ++ E+ G +PG V++L +++K E R Sbjct: 276 ALFDRV-YTHQSDVWSFGVLMWEIFTLGGSPYPGI-PVEELFKLLK-------EGHRMDK 326 Query: 286 PNYTEFKFPQIKAHPWTKVFRPRTPPEAIAL---CSRLLEY 323 P + + W V P P L R+L Sbjct: 327 PANCTNELYMMMRDCWHAV--PSQRPTFKQLVEDLDRILTL 365 >5U6B-A nrPDB Length = 307 Score = 190 bits (482), Expect = 1e-48, Method: Composition-based stats. Identities = 61/292 (20%), Positives = 111/292 (38%), Gaps = 45/292 (15%) Query: 58 DTKVIGNGSFGVVYQAKLCDSGEL--VAIKKVL------QDKRFKNRELQIMRKLDHCNI 109 K +G G FG V + +L + VA+K + + E M++ DH N+ Sbjct: 27 LGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNV 86 Query: 110 VRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQT---LPVIYVKLYMYQLF 166 +RL + E++ ++L ++ YSR LP + +M + Sbjct: 87 MRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIA 146 Query: 167 RSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY---YR 223 + Y+ + HRD+ +N +L+ + +V + DFG +K++ G+ ++ + Sbjct: 147 SGMEYLSTKRFIHRDLAARNCMLNENMSVC-VADFGLSKKIYNGDYYRQGRIAKMPVKWI 205 Query: 224 APELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIR 282 A E + YTS DVWS G + E+ GQ +PG + + + G ++ Sbjct: 206 AIESLADRV-YTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQ--GNRLKQPAD 262 Query: 283 EMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEA 334 ++ Y L SR E P R + E Sbjct: 263 CLDGLYA--------------------------LMSRCWELNPQDRPSFTEL 288 >5A46-A nrPDB Length = 386 Score = 189 bits (481), Expect = 2e-48, Method: Composition-based stats. Identities = 73/312 (23%), Positives = 121/312 (38%), Gaps = 52/312 (16%) Query: 43 TPGQGPDRPQ----EVSYTDTKVIGNGSFGVVYQA------KLCDSGE-LVAIKKVLQDK 91 + + P+ P+ K +G G FG V A K + VA+K + D Sbjct: 25 SEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDA 84 Query: 92 RFKN-----RELQIMRKL-DHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARH 145 K+ E+++M+ + H NI+ L G L ++++Y + R Sbjct: 85 TEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGP------LYVIVEYASKGNLREYLQ 138 Query: 146 YSRA-------------KQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPD 192 R ++ L + YQ+ R + Y+ S HRD+ +N+L+ D Sbjct: 139 ARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTED 198 Query: 193 TAVLKLCDFGSAKQLVRGEPNVSYICSRY---YRAPELIFGATDYTSSIDVWSAGCVLAE 249 V+K+ DFG A+ + + R + APE +F YT DVWS G +L E Sbjct: 199 N-VMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRI-YTHQSDVWSFGVLLWE 256 Query: 250 LLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPR 308 + G +PG V++L +++K E R P+ + + W V P Sbjct: 257 IFTLGGSPYPGV-PVEELFKLLK-------EGHRMDKPSNCTNELYMMMRDCWHAV--PS 306 Query: 309 TPPEAIALCSRL 320 P L L Sbjct: 307 QRPTFKQLVEDL 318 >4H1J-A nrPDB Length = 293 Score = 189 bits (481), Expect = 2e-48, Method: Composition-based stats. Identities = 65/284 (22%), Positives = 112/284 (39%), Gaps = 52/284 (18%) Query: 58 DTKVIGNGSFGVVYQAK---LCDSGELVAIKKVLQD-----KRFKNRELQIMRKLDHCNI 109 +++G G FG VY+ VA+K +D K E IM+ LDH +I Sbjct: 28 LNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHI 87 Query: 110 VRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 169 V+L ++++ P + + R K +L V+ + LY Q+ +++ Sbjct: 88 VKLIGIIEEEPT-------WIIMELYPYG--ELGHYLERNKNSLKVLTLVLYSLQICKAM 138 Query: 170 AYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY---YRAPE 226 AY+ S HRDI +N+L+ V KL DFG ++ + + + + +R + +PE Sbjct: 139 AYLESINCVHRDIAVRNILVASPECV-KLGDFGLSRYIEDEDYYKASV-TRLPIKWMSPE 196 Query: 227 LIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMN 285 I +T++ DVW + E+L G+ F D + + K P + Sbjct: 197 SI-NFRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDL----- 250 Query: 286 PNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARL 329 PP L +R +Y P+ R Sbjct: 251 -----------------------CPPVLYTLMTRCWDYDPSDRP 271 >2J0K-A nrPDB Length = 656 Score = 189 bits (481), Expect = 2e-48, Method: Composition-based stats. Identities = 73/319 (22%), Positives = 115/319 (36%), Gaps = 53/319 (16%) Query: 25 SMKVSRDKDGSKVTT---VVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLC---DS 78 ++ VS D +++ P Q + IG G FG V+Q + Sbjct: 358 TVSVSETDDYAEIIDEEDTYTMPSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENP 417 Query: 79 GELVAIKKVLQ-----DKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLD 133 VAIK + +E MR+ DH +IV+L E + ++++ Sbjct: 418 AMAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVI-------TENPVWIIME 470 Query: 134 YVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDT 193 R + +L + + LY YQL +LAY+ S HRDI +N+L+ Sbjct: 471 LCTLGELRSFLQVRKF--SLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSATD 528 Query: 194 AVLKLCDFGSAKQLVRGEPNVSYICSRY--YRAPELIFGATDYTSSIDVWSAGCVLAELL 251 V KL DFG ++ + + + APE I +TS+ DVW G + E+L Sbjct: 529 CV-KLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESI-NFRRFTSASDVWMFGVCMWEIL 586 Query: 252 L-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTP 310 + G F G D + I P P P Sbjct: 587 MHGVKPFQGVKNNDVIGRIENGERLP----------------------------MPPNCP 618 Query: 311 PEAIALCSRLLEYTPTARL 329 P +L ++ Y P+ R Sbjct: 619 PTLYSLMTKCWAYDPSRRP 637 >3DLS-A nrPDB Length = 335 Score = 189 bits (479), Expect = 3e-48, Method: Composition-based stats. Identities = 65/286 (22%), Positives = 122/286 (42%), Gaps = 36/286 (12%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN------------RELQIMRK 103 Y+ +G+G+FG V+ A + + V +K + ++K ++ E+ I+ + Sbjct: 26 YSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSR 85 Query: 104 LDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMY 163 ++H NI+++ F + G + LV++ + A + L Sbjct: 86 VEHANIIKVLDIFENQG------FFQLVMEKHGSGLDLFA--FIDRHPRLDEPLASYIFR 137 Query: 164 QLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYR 223 QL ++ Y+ I HRDIK +N+++ D +KL DFGSA L RG+ ++ + Y Sbjct: 138 QLVSAVGYLRLKDIIHRDIKDENIVIAEDFT-IKLIDFGSAAYLERGKLFYTFCGTIEYC 196 Query: 224 APELIFGATDYTSSIDVWSAGCVLAELLLGQPIF------------PGDSGVDQLVEIIK 271 APE++ G +++WS G L L+ + F P +L+ ++ Sbjct: 197 APEVLMGNPYRGPELEMWSLGVTLYTLVFEENPFCELEETVEAAIHPPYLVSKELMSLVS 256 Query: 272 VLGTPTREQIREMNPNYTEFKFPQ---IKAHPWTKVFRPRTPPEAI 314 L P E+ + T+ Q + + W +VFR P + Sbjct: 257 GLLQPVPERRTTLEKLVTDPWVTQPVNLADYTWEEVFRVNKPESGV 302 >5VD3-A nrPDB Length = 311 Score = 188 bits (478), Expect = 3e-48, Method: Composition-based stats. Identities = 78/337 (23%), Positives = 126/337 (37%), Gaps = 55/337 (16%) Query: 16 PVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEV---SYTDTKVIGNGSFGVVYQ 72 Q +VS + + + +PG P RP+ S+ +G+GS+G V++ Sbjct: 19 YFQSMHQLQPRRVS---FRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFK 75 Query: 73 AKLCDSGELVAIKKVL------QDKRFKNRELQIMRKL-DHCNIVRLRYFFYSSGEKKDE 125 + + G L A+K+ + +D+ K E+ K+ H VRL + G Sbjct: 76 VRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGI---- 131 Query: 126 VYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQ 185 L L + ++ +H +LP V Y+ +LA++HS G+ H D+KP Sbjct: 132 --LYLQTELCGPSL---QQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPA 186 Query: 186 NLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGC 245 N+ L P KL DFG +L Y APEL+ G+ Y ++ DV+S G Sbjct: 187 NIFLGPR-GRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGS--YGTAADVFSLGL 243 Query: 246 VLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVF 305 + E+ + G G QL + G E F Sbjct: 244 TILEVACNMELPHGGEGWQQLRQ-----GYLPPE-------------------------F 273 Query: 306 RPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDE 342 E ++ +LE P R T A + Sbjct: 274 TAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQ 310 >5AMN-A nrPDB Length = 299 Score = 188 bits (477), Expect = 5e-48, Method: Composition-based stats. Identities = 58/290 (20%), Positives = 119/290 (41%), Gaps = 42/290 (14%) Query: 58 DTKVIGNGSFGVVYQAK-LCDSGE----LVAIKKVLQ-----DKRFKNRELQIMRKLDHC 107 K +G G FG V +A G VA+K + + + R E ++++++H Sbjct: 27 LGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHP 86 Query: 108 NIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRA-------KQTLPVIYVKL 160 ++++L G L L+++Y R SR ++ L + + Sbjct: 87 HVIKLYGACSQDGP------LLLIVEYAKYGSLRGFLRESRKVGPGYPDERALTMGDLIS 140 Query: 161 YMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSR 220 + +Q+ + + Y+ + HRD+ +N+L+ + +K+ DFG ++ + + V R Sbjct: 141 FAWQISQGMQYLAEMKLVHRDLAARNILV-AEGRKMKISDFGLSRDVYEEDSYVKRSQGR 199 Query: 221 ---YYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTP 276 + A E +F YT+ DVWS G +L E++ G +PG ++L ++K Sbjct: 200 IPVKWMAIESLFDHI-YTTQSDVWSFGVLLWEIVTLGGNPYPGIPP-ERLFNLLKTGH-- 255 Query: 277 TREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIAL---CSRLLEY 323 R P+ + ++ W + P P + +++ Sbjct: 256 -----RMERPDNCSEEMYRLMLQCWKQ--EPDKRPVFADISKDLEKMMVK 298 >5HVK-A nrPDB Length = 315 Score = 187 bits (475), Expect = 7e-48, Method: Composition-based stats. Identities = 71/342 (20%), Positives = 126/342 (36%), Gaps = 59/342 (17%) Query: 45 GQGPDR-PQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNR----ELQ 99 G P R + +V+G G FG + ++GE++ +K++++ R E++ Sbjct: 4 GSRPHRIFRPSDLIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVK 63 Query: 100 IMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVK 159 +MR L+H N+++ Y LN + +Y+ R P Sbjct: 64 VMRCLEHPNVLKFIGVLYKDKR------LNFITEYIKGGTLRGI--IKSMDSQYPWSQRV 115 Query: 160 LYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRG--------- 210 + + +AY+HS I HR++ N L+ + V+ + DFG A+ +V Sbjct: 116 SFAKDIASGMAYLHSMNIIHRNLNSHNCLVRENKNVV-VADFGLARLMVDEKTQPEGLRS 174 Query: 211 ------EPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVD 264 + + + + Y+ APE+I G + Y +DV+S G VL E Sbjct: 175 LKKPDRKKRYTVVGNPYWMAPEMINGRS-YDEKVDVFSFGIVLCE--------------- 218 Query: 265 QLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYT 324 II + R M+ F + P PP + R + Sbjct: 219 ----IIGRVNADPDYLPRTMDFGLNVRGF-------LDRYCPPNCPPSFFPITVRCCDLD 267 Query: 325 PTARLTPLEACAHSFFDELRDPNV-KLPNGRDTPALFNFTTQ 365 P R + ++ H + + LR LP G L + Sbjct: 268 PEKRPSFVK-LEH-WLETLRMHLAGHLPLGPQLEQLDRGFWE 307 >4WUA-A nrPDB Length = 401 Score = 187 bits (475), Expect = 7e-48, Method: Composition-based stats. Identities = 75/369 (20%), Positives = 135/369 (36%), Gaps = 90/369 (24%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN---RELQIMRKLDH--CN- 108 Y + +G G F V+ + + VA+K V + + E+++++ + + N Sbjct: 42 RYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPND 101 Query: 109 -----IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMY 163 +V+L F SG ++ +V + + + + Q LP+ VK + Sbjct: 102 PNREMVVQLLDDFKISGVNGT--HICMVFEVLGHHLLKWI--IKSNYQGLPLPCVKKIIQ 157 Query: 164 QLFRSLAYIHSF-GICHRDIKPQNLLL--------------------------------- 189 Q+ + L Y+H+ I H DIKP+N+LL Sbjct: 158 QVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVSTA 217 Query: 190 ---------------DPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDY 234 + + +K+ D G+A + + I +R YR+ E++ G+ Y Sbjct: 218 PATAGNFLVNPLEPKNAEKLKVKIADLGNACWVHK--HFTEDIQTRQYRSLEVLIGS-GY 274 Query: 235 TSSIDVWSAGCVLAELLLGQPIFPGDSG------VDQLVEIIKVLGTPTREQIREMNPNY 288 + D+WS C+ EL G +F SG D + II++LG R+ I + Y Sbjct: 275 NTPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLI--VAGKY 332 Query: 289 TEFKFPQ-------IKAHPW--------TKVFRPRTPPEAIALCSRLLEYTPTARLTPLE 333 ++ F + K PW + +LE P R T E Sbjct: 333 SKEFFTKKGDLKHITKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATAAE 392 Query: 334 ACAHSFFDE 342 H + + Sbjct: 393 CLRHPWLNS 401 >3ORP-A nrPDB Length = 311 Score = 187 bits (475), Expect = 8e-48, Method: Composition-based stats. Identities = 67/270 (24%), Positives = 110/270 (40%), Gaps = 23/270 (8%) Query: 42 ATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRF-------K 94 TP DR Y +++G G V+ A+ VA+K + D Sbjct: 5 TTPSHLSDR-----YELGEILGFGGMSEVHLARDLRDHRDVAVKVLRADLARDPSFYLRF 59 Query: 95 NRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLP 154 RE Q L+H IV + E +V++YV R H + + Sbjct: 60 RREAQNAAALNHPAIVAVYD--TGEAETPAGPLPYIVMEYVDGVTLRDIVH---TEGPMT 114 Query: 155 VIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNV 214 + ++L + H GI HRD+KP N+++ AV K+ DFG A+ + +V Sbjct: 115 PKRAIEVIADACQALNFSHQNGIIHRDVKPANIMISATNAV-KVMDFGIARAIADSGNSV 173 Query: 215 SY----ICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEII 270 + I + Y +PE G + + DV+S GCVL E+L G+P F GDS V + + Sbjct: 174 TQTAAVIGTAQYLSPEQARGDSV-DARSDVYSLGCVLYEVLTGEPPFTGDSPVSVAYQHV 232 Query: 271 KVLGTPTREQIREMNPNYTEFKFPQIKAHP 300 + P + ++ + + +P Sbjct: 233 REDPIPPSARHEGLSADLDAVVLKALAKNP 262 >3SXS-A nrPDB Length = 268 Score = 187 bits (475), Expect = 8e-48, Method: Composition-based stats. Identities = 64/284 (22%), Positives = 122/284 (42%), Gaps = 33/284 (11%) Query: 45 GQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGEL-VAIKKVLQDKRFKN---RELQI 100 G + +E+ T K +G+G FGVV K G+ VA+K + + ++ +E Q Sbjct: 1 GHMELKREEI--TLLKELGSGQFGVVKLGKWK--GQYDVAVKMIKEGSMSEDEFFQEAQT 56 Query: 101 MRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKL 160 M KL H +V+ E + +V +Y+ + + + L + Sbjct: 57 MMKLSHPKLVKFYGVC------SKEYPIYIVTEYISNGC--LLNYLRSHGKGLEPSQLLE 108 Query: 161 YMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSR 220 Y + +A++ S HRD+ +N L+D D V K+ DFG + ++ + VS + ++ Sbjct: 109 MCYDVCEGMAFLESHQFIHRDLAARNCLVDRDLCV-KVSDFGMTRYVL-DDQYVSSVGTK 166 Query: 221 Y---YRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTP 276 + + APE+ F Y+S DVW+ G ++ E+ G+ + + + ++++ Sbjct: 167 FPVKWSAPEV-FHYFKYSSKSDVWAFGILMWEVFSLGKMPYDLYTNSEVVLKV------- 218 Query: 277 TREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRL 320 + R P+ QI W ++ P P L S + Sbjct: 219 -SQGHRLYRPHLASDTIYQIMYSCWHEL--PEKRPTFQQLLSSI 259 >5HI2-A nrPDB Length = 283 Score = 187 bits (474), Expect = 1e-47, Method: Composition-based stats. Identities = 69/272 (25%), Positives = 115/272 (42%), Gaps = 21/272 (7%) Query: 57 TDTKVIGNGSFGVVYQAKLCDSGELVAIKKV-LQDKRFKNRELQIMRKLDHCNIVRLRYF 115 T + IG+GSFG VY+ K VA+K + Q + E+ ++RK H NI+ + Sbjct: 23 TVGQRIGSGSFGTVYKGKWHGD---VAVKMLTPQQLQAFKNEVGVLRKTRHVNILLFMGY 79 Query: 116 FYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSF 175 + L +V + + + H ++ + + Q R + Y+H+ Sbjct: 80 -------STKPQLAIVTQWCEGS--SLYHHLHASETKFEMKKLIDIARQTARGMDYLHAK 130 Query: 176 GICHRDIKPQNLLLDPDTAVLKLCDFGSA--KQLVRGEPNVSYI-CSRYYRAPELI--FG 230 I HRD+K N+ L D V K+ DFG A K G + S + APE+I Sbjct: 131 SIIHRDLKSNNIFLHEDNTV-KIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQD 189 Query: 231 ATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLG-TPTREQIREMNPNYT 289 + Y+ DV++ G VL EL+ GQ + + DQ++E++ +P ++R P Sbjct: 190 SNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEMVGRGSLSPDLSKVRSNCPKRM 249 Query: 290 EFKFPQIKAHPWTKVFR-PRTPPEAIALCSRL 320 + + + PR E L L Sbjct: 250 KRLMAECLKKKRDERPSFPRILAEIEELAREL 281 >4HZS-A nrPDB Length = 341 Score = 186 bits (473), Expect = 1e-47, Method: Composition-based stats. Identities = 70/289 (24%), Positives = 116/289 (40%), Gaps = 35/289 (12%) Query: 53 EVSYTDTKVIGNGSFGVVYQAKL-CDSGELV--AIKKVLQDKRFKN-------RELQIMR 102 E + +G+GSFGVV + + SG+ V A+K + D + RE+ M Sbjct: 11 EKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMH 70 Query: 103 KLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYM 162 LDH N++RL + + +V + P + + + + + + Y Sbjct: 71 SLDHRNLIRLYGVVLTPP-------MKMVTELAP--LGSLLDRLRKHQGHFLLGTLSRYA 121 Query: 163 YQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVS----YIC 218 Q+ + Y+ S HRD+ +NLLL ++K+ DFG + L + + + Sbjct: 122 VQVAEGMGYLESKRFIHRDLAARNLLLATRD-LVKIGDFGLMRALPQNDDHYVMQEHRKV 180 Query: 219 SRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPT 277 + APE + T ++ + D W G L E+ GQ + G +G L +I K Sbjct: 181 PFAWCAPESLKTRT-FSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDK------ 233 Query: 278 REQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPT 326 E R P + W +P P +AL LLE PT Sbjct: 234 -EGERLPRPEDCPQDIYNVMVQCWAH--KPEDRPTFVALRDFLLEAQPT 279 >6E4F-A nrPDB Length = 290 Score = 186 bits (473), Expect = 1e-47, Method: Composition-based stats. Identities = 56/281 (19%), Positives = 118/281 (41%), Gaps = 33/281 (11%) Query: 50 RPQEVSYTDTKVIGNGSFGVVYQAKLCDSGEL-VAIKKVLQDKRFKNR---ELQIMRKLD 105 P+++++ K +G G FGVV K G+ VAIK + + ++ E ++M L Sbjct: 29 DPKDLTF--LKELGTGQFGVVKYGKWR--GQYDVAIKMIKEGSMSEDEFIEEAKVMMNLS 84 Query: 106 HCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQL 165 H +V+L + ++ +Y+ + + + + + Sbjct: 85 HEKLVQLYGVCTKQRP------IFIITEYMANGC--LLNYLREMRHRFQTQQLLEMCKDV 136 Query: 166 FRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY---Y 222 ++ Y+ S HRD+ +N L++ D V+K+ DFG ++ ++ E S + S++ + Sbjct: 137 CEAMEYLESKQFLHRDLAARNCLVN-DQGVVKVSDFGLSRYVLDDE-YTSSVGSKFPVRW 194 Query: 223 RAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQI 281 PE++ + ++S D+W+ G ++ E+ G+ + + + I + + Sbjct: 195 SPPEVLM-YSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHI--------AQGL 245 Query: 282 REMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLE 322 R P+ K I W + R P L S +L+ Sbjct: 246 RLYRPHLASEKVYTIMYSCWHEKADER--PTFKILLSNILD 284 >5EG3-A nrPDB Length = 334 Score = 186 bits (473), Expect = 1e-47, Method: Composition-based stats. Identities = 73/318 (22%), Positives = 124/318 (38%), Gaps = 55/318 (17%) Query: 43 TPGQGPDRPQ----EVSYTDTKVIGNGSFGVVYQAK----LCDSGEL---VAIKKVLQDK 91 + + P+ P+ T K +G G+FG V A+ D + VA+K + D Sbjct: 20 SEFELPEDPKWEFPRDKLTLGKPLGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDA 79 Query: 92 RFKN-----RELQIMRKL-DHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARH 145 K+ E+++M+ + H NI+ L G L +++ Y + R Sbjct: 80 TEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGP------LYVIVAYASKGNLREYLR 133 Query: 146 YSRA-------------KQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPD 192 R ++ + + YQL R + Y+ S HRD+ +N+L+ + Sbjct: 134 ARRPPGMELSPDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTEN 193 Query: 193 TAVLKLCDFGSAKQLVRGEPNVSYICSRY---YRAPELIFGATDYTSSIDVWSAGCVLAE 249 V+K+ DFG A+ + + R + APE +F YT DVWS G ++ E Sbjct: 194 N-VMKIADFGLARDINNIDFFKETTNGRLPVKWMAPEALFDRV-YTHQSDVWSFGVLMWE 251 Query: 250 LLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPR 308 + G +PG V++L +++K E R P + + W V P Sbjct: 252 IFTLGGSPYPGI-PVEELFKLLK-------EGHRMDKPANCTNELYMMMRDCWHAV--PS 301 Query: 309 TPPEAIAL---CSRLLEY 323 P L R+L Sbjct: 302 QRPTFKQLVEDLDRILTL 319 >4JLC-A nrPDB Length = 657 Score = 186 bits (472), Expect = 2e-47, Method: Composition-based stats. Identities = 54/292 (18%), Positives = 116/292 (39%), Gaps = 27/292 (9%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDK-----RFKNRELQIMRKLDHCNIV 110 + + ++G G+ V++ + +G+L A+K + RE ++++KL+H NIV Sbjct: 10 WLLSDILGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQMREFEVLKKLNHKNIV 69 Query: 111 RLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLA 170 +L ++ E+ + L++++ P LP + + + + Sbjct: 70 KL----FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 125 Query: 171 YIHSFGICHRDIKPQNLL--LDPDT-AVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPEL 227 ++ GI HRDIKP N++ + D +V KL DFG+A++L E VS + Y P++ Sbjct: 126 HLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDM 185 Query: 228 IFG-------ATDYTSSIDVWSAGCVLAELLLGQPIFP----GDSGVDQLVEIIKVLGTP 276 Y +++D+WS G G F + + +II + Sbjct: 186 YERAVLRKDHQKKYGATVDLWSVGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSG 245 Query: 277 TREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALC----SRLLEYT 324 +++ ++ + ++ + P + + + Sbjct: 246 AISGVQKAENGPIDWSGDMPLSCSLSQGLQALLTPVLANILEADQEKCWGFD 297 >1U54-B nrPDB Length = 291 Score = 186 bits (471), Expect = 2e-47, Method: Composition-based stats. Identities = 71/289 (24%), Positives = 115/289 (39%), Gaps = 35/289 (12%) Query: 53 EVSYTDTKVIGNGSFGVVYQAKL-CDSGELV--AIKKVLQDKRFKN-------RELQIMR 102 E + +G+GSFGVV + + SG+ V A+K + D + RE+ M Sbjct: 17 EKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMH 76 Query: 103 KLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYM 162 LDH N++RL + + +V + P + + + + + + Y Sbjct: 77 SLDHRNLIRLYGVVLTPP-------MKMVTELAP--LGSLLDRLRKHQGHFLLGTLSRYA 127 Query: 163 YQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVS----YIC 218 Q+ + Y+ S HRD+ +NLLL V K+ DFG + L + + + Sbjct: 128 VQVAEGMGYLESKRFIHRDLAARNLLLATRDLV-KIGDFGLMRALPQNDDHYVMQEHRKV 186 Query: 219 SRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPT 277 + APE + T ++ + D W G L E+ GQ + G +G L +I K Sbjct: 187 PFAWCAPESLKTRT-FSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDK------ 239 Query: 278 REQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPT 326 E R P + W +P P +AL LLE PT Sbjct: 240 -EGERLPRPEDCPQDIYNVMVQCWAH--KPEDRPTFVALRDFLLEAQPT 285 >5HIE-A nrPDB Length = 302 Score = 185 bits (470), Expect = 3e-47, Method: Composition-based stats. Identities = 67/272 (24%), Positives = 115/272 (42%), Gaps = 20/272 (7%) Query: 57 TDTKVIGNGSFGVVYQAKLCDSGELVAIKKV-LQDKRFKNRELQIMRKLDHCNIVRLRYF 115 T + IG+GSFG VY+ K VA+K + Q + E+ ++RK H NI+ + Sbjct: 39 TVGQRIGSGSFGTVYKGKWHGD---VAVKMLTPQQLQAFKNEVGVLRKTRHVNILLFMGY 95 Query: 116 FYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSF 175 + L +V + + + H + +I + Q + + Y+H+ Sbjct: 96 -------STKPQLAIVTQWCEGS--SLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAK 146 Query: 176 GICHRDIKPQNLLLDPDTAVLKLCDFGSA--KQLVRGEPNVSYI-CSRYYRAPELI--FG 230 I HRD+K N+ L D V K+ DFG A K G + S + APE+I Sbjct: 147 SIIHRDLKSNNIFLHEDLTV-KIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQD 205 Query: 231 ATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEII-KVLGTPTREQIREMNPNYT 289 Y+ DV++ G VL EL+ GQ + + DQ++ ++ + +P ++R P Sbjct: 206 KNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAM 265 Query: 290 EFKFPQIKAHPWTKVFRPRTPPEAIALCSRLL 321 + + + +I L +R L Sbjct: 266 KRLMAECLKKKRDERPLFPQILASIELLARSL 297 >4XCU-A nrPDB Length = 300 Score = 185 bits (470), Expect = 3e-47, Method: Composition-based stats. Identities = 70/300 (23%), Positives = 114/300 (38%), Gaps = 57/300 (19%) Query: 58 DTKVIGNGSFGVVYQAK-------LCDSGELVAIKKVL-----QDKRFKNRELQIMRKL- 104 K +G G FG V +A+ D VA+K + +D E+++M+ + Sbjct: 21 LGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIG 80 Query: 105 DHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSR----AKQTLPVIYVKL 160 H NI+ L G L ++++ + R R ++ L + Sbjct: 81 RHKNIINLLGVCTQEGP------LYVIVECAAKGNLREFLRARRPPGSSEGPLSFPVLVS 134 Query: 161 YMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSR 220 YQ+ R + Y+ S HRD+ +N+L+ D V+K+ DFG A+ + + R Sbjct: 135 CAYQVARGMQYLESRKCIHRDLAARNVLVTEDN-VMKIADFGLARGVHHIDYYKKTSNGR 193 Query: 221 Y---YRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTP 276 + APE +F YT DVWS G +L E+ G +PG V++L +++ Sbjct: 194 LPVKWMAPEALFDRV-YTHQSDVWSFGILLWEIFTLGGSPYPGI-PVEELFSLLR----- 246 Query: 277 TREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACA 336 E R P P PPE L P+ R T + Sbjct: 247 --EGHRMDRP--------------------PHCPPELYGLMRECWHAAPSQRPTFKQLVE 284 >3PP0-A nrPDB Length = 338 Score = 185 bits (470), Expect = 3e-47, Method: Composition-based stats. Identities = 67/302 (22%), Positives = 107/302 (35%), Gaps = 37/302 (12%) Query: 42 ATPGQGPDR-PQEVSYTDTKVIGNGSFGVVYQAKLCDSGELV----AIKKVL-----QDK 91 A P Q R +E KV+G+G+FG VY+ GE V AIK + + Sbjct: 4 AAPNQALLRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKAN 63 Query: 92 RFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQ 151 + E +M + + RL +S + LV +P + H + Sbjct: 64 KEILDEAYVMAGVGSPYVSRLLGICLTST-------VQLVTQLMPYGC--LLDHVRENRG 114 Query: 152 TLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGE 211 L + + Q+ + ++Y+ + HRD+ +N+L+ V K+ DFG A+ L E Sbjct: 115 RLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHV-KITDFGLARLLDIDE 173 Query: 212 PNVSYICSRY---YRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLV 267 + + A E I +T DVWS G + EL+ G + G + Sbjct: 174 TEYHADGGKVPIKWMALESIL-RRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPARE--- 229 Query: 268 EIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPW--TKVFRPRTPPEAIALCSRLLEYTP 325 + + R P I W RPR SR+ P Sbjct: 230 -----IPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEF-SRM-ARDP 282 Query: 326 TA 327 Sbjct: 283 QR 284 >4M7I-A nrPDB Length = 299 Score = 185 bits (469), Expect = 4e-47, Method: Composition-based stats. Identities = 63/290 (21%), Positives = 117/290 (40%), Gaps = 38/290 (13%) Query: 54 VSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ-----DKRFKNRELQIMRKLDHCN 108 + + +G G FGVV++AK AIK++ + RE++ + KL+H Sbjct: 5 TDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPG 64 Query: 109 IVRLRYFFYSSGEKK------DEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYM 162 IVR + + +VYL + + + + + + Sbjct: 65 IVRYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIF 124 Query: 163 YQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEP---------- 212 Q+ ++ ++HS G+ HRD+KP N+ D V+K+ DFG + + E Sbjct: 125 LQIAEAVEFLHSKGLMHRDLKPSNIFFTMDD-VVKVGDFGLVTAMDQDEEEQTVLTPMPA 183 Query: 213 ---NVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEI 269 + + ++ Y +PE I G + Y+ +D++S G +L ELL +P + ++++ + Sbjct: 184 YARHTGQVGTKLYMSPEQIHGNS-YSHKVDIFSLGLILFELL-----YPFSTQMERVRTL 237 Query: 270 IKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSR 319 V + P E+ Q P P PEAI + Sbjct: 238 TDVRNLKFPPLFTQKYP--CEYVMVQDMLSP-----SPMERPEAINIIEN 280 >4EQM-A nrPDB Length = 294 Score = 184 bits (468), Expect = 4e-47, Method: Composition-based stats. Identities = 71/281 (25%), Positives = 115/281 (40%), Gaps = 22/281 (7%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVL-----QDKRFK--NRELQIMRKLDHC 107 Y +G G VY A+ VAIK + +++ K RE+ +L H Sbjct: 12 RYKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETLKRFEREVHNSSQLSHQ 71 Query: 108 NIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFR 167 NIV + +++ LV++Y+ Y + L V + Q+ Sbjct: 72 NIVSMIDV------DEEDDCYYLVMEYIEGPTLS---EYIESHGPLSVDTAINFTNQILD 122 Query: 168 SLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVS--YICSRYYRAP 225 + + H I HRDIKPQN+L+D + LK+ DFG AK L + + + Y +P Sbjct: 123 GIKHAHDMRIVHRDIKPQNILIDSN-KTLKIFDFGIAKALSETSLTQTNHVLGTVQYFSP 181 Query: 226 ELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMN 285 E G D++S G VL E+L+G+P F G++ V ++ I+ +R+ Sbjct: 182 EQAKGEAT-DECTDIYSIGIVLYEMLVGEPPFNGETAVSIAIKHIQDSVPNVTTDVRKDI 240 Query: 286 PNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPT 326 P ++A K R +T E S +L Sbjct: 241 PQSLSNVI--LRATEKDKANRYKTIQEMKDDLSSVLHENRA 279 >4XI2-A nrPDB Length = 446 Score = 184 bits (468), Expect = 4e-47, Method: Composition-based stats. Identities = 55/281 (19%), Positives = 118/281 (41%), Gaps = 33/281 (11%) Query: 50 RPQEVSYTDTKVIGNGSFGVVYQAKLCDSGEL-VAIKKVLQDKRFKNR---ELQIMRKLD 105 P+++++ K +G G FGVV K G+ VAIK + + ++ E ++M L Sbjct: 185 DPKDLTF--LKELGTGQFGVVKYGKWR--GQYDVAIKMIREGSMSEDEFIEEAKVMMNLS 240 Query: 106 HCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQL 165 H +V+L + ++ +Y+ + + + + + Sbjct: 241 HEKLVQLYGVCTKQRP------IFIITEYMANGC--LLNYLREMRHRFQTQQLLEMCKDV 292 Query: 166 FRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY---Y 222 ++ Y+ S HRD+ +N L++ D V+K+ DFG ++ ++ E S + S++ + Sbjct: 293 CEAMEYLESKQFLHRDLAARNCLVN-DQGVVKVSDFGLSRYVLDDE-YTSSVGSKFPVRW 350 Query: 223 RAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQI 281 PE++ + ++S D+W+ G ++ E+ G+ + + + I + + Sbjct: 351 SPPEVLM-YSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHI--------AQGL 401 Query: 282 REMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLE 322 R P+ + I W + R P L S +L+ Sbjct: 402 RLYRPHLASERVYTIMYSCWHEKADER--PSFKILLSNILD 440 >3KUL-B nrPDB Length = 325 Score = 184 bits (468), Expect = 5e-47, Method: Composition-based stats. Identities = 67/291 (23%), Positives = 111/291 (38%), Gaps = 36/291 (12%) Query: 57 TDTKVIGNGSFGVVYQAKLCDSGEL---VAIKKVLQDKRFKNR-----ELQIMRKLDHCN 108 K+IG+G G V +L G+ VAIK + + R E IM + DH N Sbjct: 52 HIEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGYTERQRRDFLSEASIMGQFDHPN 111 Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRS 168 I+RL +V +Y+ + ++ + + + Sbjct: 112 IIRLEGVVTRGRLAM------IVTEYMENGSLDTFLRTHDGQ--FTIMQLVGMLRGVGAG 163 Query: 169 LAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRG-EPNVSYICSR---YYRA 224 + Y+ G HRD+ +N+L+D + V K+ DFG ++ L + + + + A Sbjct: 164 MRYLSDLGYVHRDLAARNVLVDSNL-VCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTA 222 Query: 225 PELIFGATDYTSSIDVWSAGCVLAE-LLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIRE 283 PE I ++S+ DVWS G V+ E L G+ + + D + + E R Sbjct: 223 PEAI-AFRTFSSASDVWSFGVVMWEVLAYGERPYWNMTNRDVI--------SSVEEGYRL 273 Query: 284 MNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRL--LEYTPTA-RLTP 331 P Q+ W K R P + S L L +P + R T Sbjct: 274 PAPMGCPHALHQLMLDCWHKDRAQR--PRFSQIVSVLDALIRSPESLRATA 322 >5U6C-A nrPDB Length = 315 Score = 184 bits (467), Expect = 6e-47, Method: Composition-based stats. Identities = 57/285 (20%), Positives = 105/285 (36%), Gaps = 26/285 (9%) Query: 58 DTKVIGNGSFGVVYQAKLCD---SGELVAIKKVLQDKRFKNR------ELQIMRKLDHCN 108 K++G G FG V + L + VA+K + D + E M+ H N Sbjct: 40 LGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPN 99 Query: 109 IVRLRYFFYSSGEKKDEVYLNLV--LDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLF 166 ++RL + + ++ + Y Y + + +P+ + +M + Sbjct: 100 VMRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIA 159 Query: 167 RSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY---YR 223 + Y+ + HRD+ +N +L D V + DFG +K++ G+ ++ + Sbjct: 160 LGMEYLSNRNFLHRDLAARNCMLRDDMTVC-VADFGLSKKIYSGDYYRQGRIAKMPVKWI 218 Query: 224 APELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIR 282 A E + YTS DVW+ G + E+ G +PG + ++ R Sbjct: 219 AIESLADRV-YTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLL--------HGHR 269 Query: 283 EMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIAL-CSRLLEYTPT 326 P + +I W R + L +LLE P Sbjct: 270 LKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESLPD 314 >4LRM-A nrPDB Length = 334 Score = 184 bits (467), Expect = 6e-47, Method: Composition-based stats. Identities = 65/307 (21%), Positives = 115/307 (37%), Gaps = 46/307 (14%) Query: 45 GQGPDRP-----QEVSYTDTKVIGNGSFGVVYQAKLCDSGELV----AIKKVL-----QD 90 G+ P++ +E + KV+G+G+FG VY+ GE V AIK++ + Sbjct: 5 GEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKA 64 Query: 91 KRFKNRELQIMRKLDHC---NIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYS 147 + E +M +D+ ++ RL +S + L+ +P + + Sbjct: 65 NKEILDEAYVMASVDNPGNPHVCRLLGICLTST-------VQLITQLMPFGC--LLDYVR 115 Query: 148 RAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQL 207 K + Y+ + Q+ + + Y+ + HRD+ +N+L+ V K+ DFG AK L Sbjct: 116 EHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHV-KITDFGLAKLL 174 Query: 208 VRGEPNVSYICSRY---YRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGV 263 E + + A E I YT DVWS G + EL+ G + G Sbjct: 175 GAEEKEYHAEGGKVPIKWMALESIL-HRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPAS 233 Query: 264 DQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALC---SRL 320 + + + + R P I W + P+ L S++ Sbjct: 234 E--------ISSILEKGERLPQPPICTIDVYMIMVKCWM--IDADSRPKFRELIIEFSKM 283 Query: 321 LEYTPTA 327 P Sbjct: 284 -ARDPQR 289 >2PL0-A nrPDB Length = 289 Score = 184 bits (467), Expect = 7e-47, Method: Composition-based stats. Identities = 62/293 (21%), Positives = 116/293 (39%), Gaps = 38/293 (12%) Query: 45 GQGPDRPQ-EVSYT-------DTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNR 96 Q P +P E + + +G G FG V+ + VA+K + Q + Sbjct: 6 TQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYY-NGHTKVAVKSLKQGSMSPDA 64 Query: 97 ---ELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTL 153 E +M++L H +VRL + + ++ +Y+ + L Sbjct: 65 FLAEANLMKQLQHQRLVRLYAVV-------TQEPIYIITEYMENGSLVDFLKTPSGIK-L 116 Query: 154 PVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPN 213 + + Q+ +A+I HRD++ N+L+ DT K+ DFG A+ L+ Sbjct: 117 TINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILV-SDTLSCKIADFGLAR-LIEDNEY 174 Query: 214 VSYICSRY---YRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEI 269 + +++ + APE I +T DVWS G +L E++ G+ +PG + + + + Sbjct: 175 TAREGAKFPIKWTAPEAI-NYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNL 233 Query: 270 IKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLE 322 + R + P+ + Q+ W + RP P +LE Sbjct: 234 ER--------GYRMVRPDNCPEELYQLMRLCWKE--RPEDRPTF-DYLRSVLE 275 >5O0Y-A nrPDB Length = 579 Score = 184 bits (466), Expect = 8e-47, Method: Composition-based stats. Identities = 66/300 (22%), Positives = 112/300 (37%), Gaps = 57/300 (19%) Query: 67 FGVVYQAKLCDSGELVAIK-----KVLQDKRFKN------RELQIMRKLDHCNIVRLRYF 115 F VY+A VA+K K +D++ +N RE +I ++LDH IV+L + Sbjct: 297 FSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDY 356 Query: 116 FYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSF 175 F + VL+Y Y + + + + + Q+ +L Y++ Sbjct: 357 FSLDTDS-----FCTVLEYCEGNDLD---FYLKQHKLMSEKEARSIIMQIVNALKYLNEI 408 Query: 176 G--ICHRDIKPQNLLL--DPDTAVLKLCDFGSAKQLVRGEPNVS--------YICSRYYR 223 I H D+KP N+LL +K+ DFG +K + N + +Y Sbjct: 409 KPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYL 468 Query: 224 APELI---FGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQ 280 PE ++ +DVWS G + + L G+ F + +++ +L Sbjct: 469 PPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTIL------- 521 Query: 281 IREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF 340 TE +FP +P PEA A R L Y R+ + + Sbjct: 522 ------KATEVQFPP----------KPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 565 >1U59-A nrPDB Length = 287 Score = 184 bits (466), Expect = 9e-47, Method: Composition-based stats. Identities = 64/271 (23%), Positives = 110/271 (40%), Gaps = 33/271 (12%) Query: 62 IGNGSFGVVYQAKLCDSGEL--VAIKKVLQ-----DKRFKNRELQIMRKLDHCNIVRLRY 114 +G G+FG V Q + VAIK + Q D RE QIM +LD+ IVRL Sbjct: 18 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 77 Query: 115 FFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHS 174 + L LV++ + ++ +PV V ++Q+ + Y+ Sbjct: 78 VCQAEA-------LMLVMEMAGGGPLH--KFLVGKREEIPVSNVAELLHQVSMGMKYLEE 128 Query: 175 FGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVS-YICSRY---YRAPELIFG 230 HRD+ +N+LL + K+ DFG +K L + + ++ + APE I Sbjct: 129 KNFVHRDLAARNVLL-VNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI-N 186 Query: 231 ATDYTSSIDVWSAGCVLAELL-LGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYT 289 ++S DVWS G + E L GQ + G + + I + R P Sbjct: 187 FRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFI--------EQGKRMECPPEC 238 Query: 290 EFKFPQIKAHPWTKVFRPRTPPEAIALCSRL 320 + + + W +++ P+ + + R+ Sbjct: 239 PPELYALMSDCW--IYKWEDRPDFLTVEQRM 267 >2OZO-A nrPDB Length = 613 Score = 184 bits (466), Expect = 9e-47, Method: Composition-based stats. Identities = 68/321 (21%), Positives = 123/321 (38%), Gaps = 41/321 (12%) Query: 20 PSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK--------VIGNGSFGVVY 71 P + + T+V +P P+ ++ + +G G+FG V Sbjct: 294 PEPARITSPDKPRPMPMDTSVFESPFSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVR 353 Query: 72 QAKLCDSGEL--VAIKKVLQ-----DKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKD 124 Q + VAIK + Q D RE QIM +LD+ IVRL + Sbjct: 354 QGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEA---- 409 Query: 125 EVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKP 184 L LV++ + ++ +PV V ++Q+ + Y+ HR++ Sbjct: 410 ---LMLVMEMAGGGPLH--KFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRNLAA 464 Query: 185 QNLLLDPDTAVLKLCDFGSAKQLVRGEPNVS-YICSRY---YRAPELIFGATDYTSSIDV 240 +N+LL + K+ DFG +K L + + ++ + APE I ++S DV Sbjct: 465 RNVLL-VNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI-NFRKFSSRSDV 522 Query: 241 WSAGCVLAELL-LGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH 299 WS G + E L GQ + G + + I + R P + + + Sbjct: 523 WSYGVTMWEALSYGQKPYKKMKGPEVMAFI--------EQGKRMECPPECPPELYALMSD 574 Query: 300 PWTKVFRPRTPPEAIALCSRL 320 W +++ P+ + + R+ Sbjct: 575 CW--IYKWEDRPDFLTVEQRM 593 >4AT3-A nrPDB Length = 299 Score = 183 bits (465), Expect = 1e-46, Method: Composition-based stats. Identities = 55/292 (18%), Positives = 106/292 (36%), Gaps = 40/292 (13%) Query: 58 DTKVIGNGSFGVVYQAKLCD-----SGELVAIKKVL----QDKRFKNRELQIMRKLDHCN 108 + +G G+FG V+ A+ + LVA+K + ++ +RE +++ L H + Sbjct: 17 LKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEH 76 Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYR----------VARHYSRAKQTLPVIYV 158 IV+ L +V +Y+ V L + Sbjct: 77 IVKFYGVCVEGDP------LIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQM 130 Query: 159 KLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYIC 218 Q+ + Y+ S HRD+ +N L+ + ++K+ DFG ++ + + Sbjct: 131 LHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENL-LVKIGDFGMSRDVYSTDYYRVGGH 189 Query: 219 S---RYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLG 274 + + PE I +T+ DVWS G VL E+ G+ + S + + I Sbjct: 190 TMLPIRWMPPESIM-YRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECIT---- 244 Query: 275 TPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIA-LCSRLLEYTP 325 + P + ++ W + R + I L L + +P Sbjct: 245 ----QGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASP 292 >5X02-A nrPDB Length = 347 Score = 183 bits (465), Expect = 1e-46, Method: Composition-based stats. Identities = 71/307 (23%), Positives = 119/307 (38%), Gaps = 57/307 (18%) Query: 51 PQEVSYTDTKVIGNGSFGVVYQAK---LCDSGE--LVAIKKVLQDKRFKNRE-----LQI 100 P+E + KV+G+G+FG V A + +G VA+K + + RE L++ Sbjct: 46 PRE-NLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKM 104 Query: 101 MRKL-DHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVK 159 M +L H NIV L SG + L+ +Y + + ++ ++ Sbjct: 105 MTQLGSHENIVNLLGACTLSGP------IYLIFEYCCYG--DLLNYLRSKREKFSEDEIE 156 Query: 160 L----------------------YMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLK 197 + YQ+ + + ++ HRD+ +N+L+ V+K Sbjct: 157 YENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTH-GKVVK 215 Query: 198 LCDFGSAKQLVRGEPNVSYICSRY---YRAPELIFGATDYTSSIDVWSAGCVLAELLL-G 253 +CDFG A+ ++ V +R + APE +F YT DVWS G +L E+ G Sbjct: 216 ICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLF-EGIYTIKSDVWSYGILLWEIFSLG 274 Query: 254 QPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEA 313 +PG ++I+ + P Y + I W F R P Sbjct: 275 VNPYPGIPVDANFYKLIQ-------NGFKMDQPFYATEEIYIIMQSCWA--FDSRKRPSF 325 Query: 314 IALCSRL 320 L S L Sbjct: 326 PNLTSFL 332 >4XUF-A nrPDB Length = 297 Score = 183 bits (465), Expect = 1e-46, Method: Composition-based stats. Identities = 71/307 (23%), Positives = 119/307 (38%), Gaps = 57/307 (18%) Query: 51 PQEVSYTDTKVIGNGSFGVVYQAK---LCDSGE--LVAIKKVLQDKRFKNRE-----LQI 100 P+E + KV+G+G+FG V A + +G VA+K + + RE L++ Sbjct: 7 PRE-NLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKM 65 Query: 101 MRKL-DHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVK 159 M +L H NIV L SG + L+ +Y + + ++ ++ Sbjct: 66 MTQLGSHENIVNLLGACTLSGP------IYLIFEYCCYG--DLLNYLRSKREKFSEDEIE 117 Query: 160 L----------------------YMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLK 197 + YQ+ + + ++ HRD+ +N+L+ V+K Sbjct: 118 YENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTH-GKVVK 176 Query: 198 LCDFGSAKQLVRGEPNVSYICSRY---YRAPELIFGATDYTSSIDVWSAGCVLAELLL-G 253 +CDFG A+ ++ V +R + APE +F YT DVWS G +L E+ G Sbjct: 177 ICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLF-EGIYTIKSDVWSYGILLWEIFSLG 235 Query: 254 QPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEA 313 +PG ++I+ + P Y + I W F R P Sbjct: 236 VNPYPGIPVDANFYKLIQ-------NGFKMDQPFYATEEIYIIMQSCWA--FDSRKRPSF 286 Query: 314 IALCSRL 320 L S L Sbjct: 287 PNLTSFL 293 >4EUU-A nrPDB Length = 319 Score = 183 bits (465), Expect = 1e-46, Method: Composition-based stats. Identities = 54/292 (18%), Positives = 116/292 (39%), Gaps = 27/292 (9%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDK-----RFKNRELQIMRKLDHCNIV 110 + + ++G G+ V++ + +G+L AIK + RE ++++KL+H NIV Sbjct: 11 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIV 70 Query: 111 RLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLA 170 +L ++ E+ + L++++ P LP + + + + Sbjct: 71 KL----FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 126 Query: 171 YIHSFGICHRDIKPQNLL--LDPDT-AVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPEL 227 ++ GI HR+IKP N++ + D +V KL DFG+A++L E VS + Y P++ Sbjct: 127 HLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDM 186 Query: 228 IFG-------ATDYTSSIDVWSAGCVLAELLLGQPIFP----GDSGVDQLVEIIKVLGTP 276 Y +++D+WS G G F + + +II + Sbjct: 187 YERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSG 246 Query: 277 TREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALC----SRLLEYT 324 +++ ++ + ++ + P + + + Sbjct: 247 AISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFD 298 >4EUT-A nrPDB Length = 396 Score = 183 bits (465), Expect = 1e-46, Method: Composition-based stats. Identities = 54/292 (18%), Positives = 116/292 (39%), Gaps = 27/292 (9%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDK-----RFKNRELQIMRKLDHCNIV 110 + + ++G G+ V++ + +G+L AIK + RE ++++KL+H NIV Sbjct: 11 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIV 70 Query: 111 RLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLA 170 +L ++ E+ + L++++ P LP + + + + Sbjct: 71 KL----FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 126 Query: 171 YIHSFGICHRDIKPQNLL--LDPDT-AVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPEL 227 ++ GI HR+IKP N++ + D +V KL DFG+A++L E VS + Y P++ Sbjct: 127 HLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDM 186 Query: 228 IFG-------ATDYTSSIDVWSAGCVLAELLLGQPIFP----GDSGVDQLVEIIKVLGTP 276 Y +++D+WS G G F + + +II + Sbjct: 187 YERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSG 246 Query: 277 TREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALC----SRLLEYT 324 +++ ++ + ++ + P + + + Sbjct: 247 AISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFD 298 >6CTH-A nrPDB Length = 309 Score = 183 bits (464), Expect = 1e-46, Method: Composition-based stats. Identities = 74/314 (23%), Positives = 118/314 (37%), Gaps = 35/314 (11%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKV----LQDKRFKNRELQIMRKLDHCNIV 110 ++ +G G FG VY+ L DS +A+KKV Q + E++I+ +L H N+V Sbjct: 16 NFNAENKLGEGGFGSVYRGFLRDSDTYIAVKKVSRASKQGIKEYASEVKIISRLRHKNLV 75 Query: 111 RLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLA 170 +L + + GE L LV +++ H + K L + L +L Sbjct: 76 KLIGWCHERGE------LMLVYEFMANGSLD--SHIFKGKSLLTWEVRYRIVKDLASALL 127 Query: 171 YIHSFG---ICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVR--GEPNVSYICSRYYRAP 225 Y+H G + HRDIK N++LD KL DFG A+ + G + Y AP Sbjct: 128 YLHEEGDHCVLHRDIKTSNIMLDSSFNA-KLGDFGLARLVDHAKGLKKTLLAGTVGYMAP 186 Query: 226 ELIFGATDYTSSIDVWSAGCVLAELLLG-QPIFPGDSGVDQLVEIIKVLGTPTREQIREM 284 E + + + DV+S G V E+ G + I P + L+ + V + E+I ++ Sbjct: 187 ECL-SSGKASKESDVYSFGVVALEIASGRRSIEPKFEESEALLLVPWVWESYGNERILDI 245 Query: 285 NPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELR 344 F + V P R + + Sbjct: 246 ADRKLGMAFDPKQLECLVMVGLWCAHPS------------HNLRPSIRQVIQ---VLNFE 290 Query: 345 DPNVKLPNGRDTPA 358 P LP P Sbjct: 291 APLPNLPGSMPIPN 304 >1FVR-A nrPDB Length = 327 Score = 183 bits (464), Expect = 1e-46, Method: Composition-based stats. Identities = 61/301 (20%), Positives = 105/301 (34%), Gaps = 58/301 (19%) Query: 57 TDTKVIGNGSFGVVYQAKLCDSGELV--AIKKVLQ-----DKRFKNRELQIMRKL-DHCN 108 VIG G+FG V +A++ G + AIK++ + D R EL+++ KL H N Sbjct: 28 KFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPN 87 Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQT-------------LPV 155 I+ L G YL L ++Y P SR +T L Sbjct: 88 IINLLGACEHRG------YLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSS 141 Query: 156 IYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVS 215 + + + R + Y+ HRD+ +N+L+ + V K+ DFG ++ Sbjct: 142 QQLLHFAADVARGMDYLSQKQFIHRDLAARNILVG-ENYVAKIADFGLSRGQEVYVKKTM 200 Query: 216 YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLG 274 + A E + + YT++ DVWS G +L E++ G + G + + Sbjct: 201 GRLPVRWMAIESL-NYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAE---------- 249 Query: 275 TPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEA 334 + + E L + P R + + Sbjct: 250 ------------------LYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQI 291 Query: 335 C 335 Sbjct: 292 L 292 >3A4O-X nrPDB Length = 286 Score = 183 bits (464), Expect = 1e-46, Method: Composition-based stats. Identities = 55/259 (21%), Positives = 106/259 (40%), Gaps = 26/259 (10%) Query: 57 TDTKVIGNGSFGVVYQAKLCDSGELVAIKKVL---QDKRFKNRELQIMRKLDHCNIVRLR 113 K +G G FG V+ +S + VA+K + + E +M+ L H +VRL Sbjct: 16 KLVKRLGAGQFGEVWMGYYNNSTK-VAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLY 74 Query: 114 YFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIH 173 E + ++ +Y+ + + L + + + Q+ +AYI Sbjct: 75 AVV------TREEPIYIITEYMAKGSLLDFLKSDEGGKVL-LPKLIDFSAQIAEGMAYIE 127 Query: 174 SFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY---YRAPELIFG 230 HRD++ N+L+ ++ + K+ DFG A+ ++ + +++ + APE I Sbjct: 128 RKNYIHRDLRAANVLV-SESLMCKIADFGLAR-VIEDNEYTAREGAKFPIKWTAPEAI-N 184 Query: 231 ATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYT 289 +T DVWS G +L E++ G+ +PG + D + + + P E + Sbjct: 185 FGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPD------ 238 Query: 290 EFKFPQIKAHPWTKVFRPR 308 + I W + R Sbjct: 239 --ELYDIMKMCWKEKAEER 255 >5B2L-A nrPDB Length = 324 Score = 183 bits (464), Expect = 2e-46, Method: Composition-based stats. Identities = 71/344 (20%), Positives = 129/344 (37%), Gaps = 55/344 (15%) Query: 50 RPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQD--KRFKNRELQ----IMRK 103 + + + +G+G+ G V++ + +G ++A+K++ + K R L +++ Sbjct: 13 QAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKS 72 Query: 104 LDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMY 163 D IV+ F ++ + + + ++ + + ++ + R + +P + Sbjct: 73 HDCPYIVQCFGTFITNTD------VFIAMELMGTSAEKLKK---RMQGPIPERILGKMTV 123 Query: 164 QLFRSLAYI-HSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYY 222 + ++L Y+ G+ HRD+KP N+LLD + +KLCDFG + +LV + Y Sbjct: 124 AIVKALYYLKEKHGVIHRDVKPSNILLD-ERGQIKLCDFGISGRLVDSKAKTRSAGCAAY 182 Query: 223 RAPELIF----GATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTR 278 APE I DY DVWS G L EL GQ FP + + KVL Sbjct: 183 MAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQ--FPYKNCKTDFEVLTKVLQEEP- 239 Query: 279 EQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHS 338 P + H + + L R + HS Sbjct: 240 ---------------PLLPGH-------MGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHS 277 Query: 339 FFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLAT-ILIPPH 381 F V + + F + P + +L PH Sbjct: 278 FIKRYETLEVDVASW--------FKDVMAKTESPRTSGVLSQPH 313 >4Y93-A nrPDB Length = 446 Score = 182 bits (463), Expect = 2e-46, Method: Composition-based stats. Identities = 56/281 (19%), Positives = 117/281 (41%), Gaps = 33/281 (11%) Query: 50 RPQEVSYTDTKVIGNGSFGVVYQAKLCDSGEL-VAIKKVLQDKRFKNR---ELQIMRKLD 105 P+++++ K +G G FGVV K G+ VAIK + + ++ E ++M L Sbjct: 186 DPKDLTF--LKELGTGQFGVVKYGKWR--GQYDVAIKMIKEGSMSEDEFIEEAKVMMNLS 241 Query: 106 HCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQL 165 H +V+L + ++ +Y+ + + + + + Sbjct: 242 HEKLVQLYGVCTKQRP------IFIITEYMANGC--LLNYLREMRHRFQTQQLLEMCKDV 293 Query: 166 FRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY---Y 222 ++ Y+ S HRD+ +N L++ D V+K+ DFG + ++ E S S++ + Sbjct: 294 CEAMEYLESKQFLHRDLAARNCLVN-DQGVVKVSDFGMTRYVLDDE-YTSSTGSKFPVKW 351 Query: 223 RAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQI 281 +PE++ + ++S D+W+ G ++ E+ G+ + + + I + L P Sbjct: 352 ASPEVLM-YSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLP----- 405 Query: 282 REMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLE 322 P+ + I W + R P L S +L+ Sbjct: 406 ---RPHLASERVYAIMYSCWHEKADER--PTFKILLSNILD 441 >2BUJ-A nrPDB Length = 317 Score = 182 bits (462), Expect = 2e-46, Method: Composition-based stats. Identities = 71/306 (23%), Positives = 114/306 (37%), Gaps = 50/306 (16%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVL----QDKRFKNRELQIMRKLDHCNIV 110 Y + +G G F V + G A+K++L QD+ RE + R +H NI+ Sbjct: 30 HYLFIQKLGEGGFSYVDLVEGLHDGHFYALKRILCHEQQDREEAQREADMHRLFNHPNIL 89 Query: 111 RLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLA 170 RL + K E +L L + T++ L + + + R L Sbjct: 90 RLVAYCLRERGAKHEAWLLLPF-FKRGTLWNEIERLKDKGNFLTEDQILWLLLGICRGLE 148 Query: 171 YIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGS----------AKQLVRGEPNVSYICSR 220 IH+ G HRD+KP N+LL + + L D GS ++Q + + + C+ Sbjct: 149 AIHAKGYAHRDLKPTNILLGDEGQPV-LMDLGSMNQACIHVEGSRQALTLQDWAAQRCTI 207 Query: 221 YYRAPEL--IFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTR 278 YRAPEL + DVWS GCVL ++ G+ + D + + + + Sbjct: 208 SYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPY------DMVFQKGDSVALAVQ 261 Query: 279 EQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTAR------LTPL 332 + PQ PR L + ++ P R L+ L Sbjct: 262 ----------NQLSIPQ----------SPRHSSALWQLLNSMMTVDPHQRPHIPLLLSQL 301 Query: 333 EACAHS 338 EA Sbjct: 302 EALQPP 307 >5FM2-A nrPDB Length = 355 Score = 182 bits (461), Expect = 3e-46, Method: Composition-based stats. Identities = 65/362 (17%), Positives = 137/362 (37%), Gaps = 63/362 (17%) Query: 1 MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATP-GQGPDRPQEVSYTDT 59 M+ R +F S + S+ ++ ++ P + P + + Sbjct: 16 MTFRRPAQAFPVS--YSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRK----NLVLG 69 Query: 60 KVIGNGSFGVVYQAK-LCDSGE----LVAIKKVLQ-----DKRFKNRELQIMRKLDHCNI 109 K +G G FG V +A G VA+K + + + R E ++++++H ++ Sbjct: 70 KTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHV 129 Query: 110 VRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRA-------------------- 149 ++L G L L+++Y R SR Sbjct: 130 IKLYGACSQDGP------LLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHP 183 Query: 150 -KQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLV 208 ++ L + + + +Q+ + + Y+ + HRD+ +N+L+ + +K+ DFG ++ + Sbjct: 184 DERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILV-AEGRKMKISDFGLSRDVY 242 Query: 209 RGEPNVSYICSR---YYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVD 264 + V R + A E +F YT+ DVWS G +L E++ G +PG + Sbjct: 243 EEDSYVKRSQGRIPVKWMAIESLFDHI-YTTQSDVWSFGVLLWEIVTLGGNPYPGIPP-E 300 Query: 265 QLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIAL---CSRLL 321 +L ++K R P+ + ++ W + P P + +++ Sbjct: 301 RLFNLLKTGH-------RMERPDNCSEEMYRLMLQCWKQ--EPDKRPVFADISKDLEKMM 351 Query: 322 EY 323 Sbjct: 352 VK 353 >6NT9-A nrPDB Length = 742 Score = 181 bits (460), Expect = 4e-46, Method: Composition-based stats. Identities = 54/292 (18%), Positives = 116/292 (39%), Gaps = 27/292 (9%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDK-----RFKNRELQIMRKLDHCNIV 110 + + ++G G+ V++ + +G+L AIK + RE ++++KL+H NIV Sbjct: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIV 68 Query: 111 RLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLA 170 +L ++ E+ + L++++ P LP + + + + Sbjct: 69 KL----FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 124 Query: 171 YIHSFGICHRDIKPQNLL--LDPDT-AVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPEL 227 ++ GI HR+IKP N++ + D +V KL DFG+A++L E VS + Y P++ Sbjct: 125 HLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDM 184 Query: 228 IFG-------ATDYTSSIDVWSAGCVLAELLLGQPIFP----GDSGVDQLVEIIKVLGTP 276 Y +++D+WS G G F + + +II + Sbjct: 185 YERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSG 244 Query: 277 TREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALC----SRLLEYT 324 +++ ++ + ++ + P + + + Sbjct: 245 AISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFD 296 >6O8B-A nrPDB Length = 665 Score = 181 bits (460), Expect = 4e-46, Method: Composition-based stats. Identities = 53/292 (18%), Positives = 115/292 (39%), Gaps = 27/292 (9%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDK-----RFKNRELQIMRKLDHCNIV 110 + + ++G G+ V++ + +G+L AIK + RE ++++KL+H NIV Sbjct: 17 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIV 76 Query: 111 RLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLA 170 +L ++ E+ + L++++ P LP + + + + Sbjct: 77 KL----FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 132 Query: 171 YIHSFGICHRDIKPQNLL--LDPDT-AVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPEL 227 ++ GI HR+IKP N++ + D +V KL DFG+A++L E V + Y P++ Sbjct: 133 HLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVELYGTEEYLHPDM 192 Query: 228 IFG-------ATDYTSSIDVWSAGCVLAELLLGQPIFP----GDSGVDQLVEIIKVLGTP 276 Y +++D+WS G G F + + +II + Sbjct: 193 YERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSG 252 Query: 277 TREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALC----SRLLEYT 324 +++ ++ + ++ + P + + + Sbjct: 253 AISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFD 304 >3OMV-A nrPDB Length = 307 Score = 181 bits (459), Expect = 5e-46, Method: Composition-based stats. Identities = 57/238 (23%), Positives = 103/238 (43%), Gaps = 25/238 (10%) Query: 62 IGNGSFGVVYQAKLCDSGELVAIKKVL------QDKRFKNRELQIMRKLDHCNIVRLRYF 115 IG+GSFG VY+ K VA+K + + + E+ ++RK H NI+ + Sbjct: 44 IGSGSFGTVYKGKWHGD---VAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGY 100 Query: 116 FYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSF 175 L +V + + + +H + + + Q + + Y+H+ Sbjct: 101 MTKDN-------LAIVTQWCEGS--SLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAK 151 Query: 176 GICHRDIKPQNLLLDPDTAVLKLCDFGSA--KQLVRGEPNVSY-ICSRYYRAPELI--FG 230 I HRD+K N+ L + +K+ DFG A K G V S + APE+I Sbjct: 152 NIIHRDMKSNNIFL-HEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQD 210 Query: 231 ATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEII-KVLGTPTREQIREMNPN 287 ++ DV+S G VL EL+ G+ + + DQ++ ++ + +P ++ + P Sbjct: 211 NNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPK 268 >4C59-A nrPDB Length = 340 Score = 181 bits (459), Expect = 5e-46, Method: Composition-based stats. Identities = 82/347 (23%), Positives = 133/347 (38%), Gaps = 62/347 (17%) Query: 53 EVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNR----ELQIMRKLD-HC 107 E+ +V+ G F VY+A+ SG A+K++L ++ KNR E+ M+KL H Sbjct: 26 ELRLRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRAIIQEVCFMKKLSGHP 85 Query: 108 NIVRLRYFFYSSGEKKD--EVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQL 165 NIV+ E+ D + L+ + + + ++ L V YQ Sbjct: 86 NIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKK-MESRGPLSCDTVLKIFYQT 144 Query: 166 FRSLAYIHSFG--ICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRG------------- 210 R++ ++H I HRD+K +NLLL + +KLCDFGSA + Sbjct: 145 CRAVQHMHRQKPPIIHRDLKVENLLL-SNQGTIKLCDFGSATTISHYPDYSWSAQRRALV 203 Query: 211 EPNVSYICSRYYRAPELIFGATDY--TSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVE 268 E ++ + YR PE+I +++ D+W+ GC+L L Q F Sbjct: 204 EEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFE---------- 253 Query: 269 IIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTAR 328 ++R +N Y+ I H +L +L+ P R Sbjct: 254 --------DGAKLRIVNGKYS------IPPHDTQYTVFH-------SLIRAMLQVNPEER 292 Query: 329 LTPLEA---CAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPP 372 L+ E R+ N K P + + LS PP Sbjct: 293 LSIAEVVHQLQE--IAAARNVNPKSPITELLEQNGGYGSATLSRGPP 337 >5UIU-A nrPDB Length = 323 Score = 180 bits (458), Expect = 7e-46, Method: Composition-based stats. Identities = 55/206 (26%), Positives = 88/206 (42%), Gaps = 22/206 (10%) Query: 61 VIGNGSFGVVYQAKLCDSGELVAIKKV--------LQDKRFKNRELQIMRKLDHCNIVRL 112 +G G FGVVY+ + ++ VA+KK+ + K+ ++E+++M K H N+V L Sbjct: 54 KMGEGGFGVVYKGYVNNT--TVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVEL 111 Query: 113 RYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYI 172 F + L LV Y+P L + ++ Sbjct: 112 LGFSSDGDD------LCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFL 165 Query: 173 HSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAK---QLVRGEPNVSYICSRYYRAPELIF 229 H HRDIK N+LLD + K+ DFG A+ + + + + Y APE + Sbjct: 166 HENHHIHRDIKSANILLD-EAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALR 224 Query: 230 GATDYTSSIDVWSAGCVLAELLLGQP 255 G T D++S G VL E++ G P Sbjct: 225 GEI--TPKSDIYSFGVVLLEIITGLP 248 >5HLW-A nrPDB Length = 299 Score = 180 bits (456), Expect = 1e-45, Method: Composition-based stats. Identities = 68/285 (23%), Positives = 115/285 (40%), Gaps = 35/285 (12%) Query: 51 PQEVSYTDTKVIGNGSFGVVYQAKLCDS-GELV--AIKKVLQ-----DKRFKNRELQIMR 102 P + +VIG G FG VY L D+ G+ + A+K + + + E IM+ Sbjct: 17 PSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMK 76 Query: 103 KLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLP-VIYVKLY 161 H N++ L S +VL Y+ R++ R + P V + + Sbjct: 77 DFSHPNVLSLLGICLRSEGSP-----LVVLPYMKHG---DLRNFIRNETHNPTVKDLIGF 128 Query: 162 MYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICS-- 219 Q+ + + Y+ S HRD+ +N +LD V K+ DFG A+ + E + + Sbjct: 129 GLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTV-KVADFGLARDMHDKEYYSVHNKTGA 187 Query: 220 ---RYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGT 275 + A E + +T+ DVWS G +L EL+ G P +P + D V ++ Sbjct: 188 KLPVKWMALESL-QTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLL----- 241 Query: 276 PTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRL 320 + R + P Y ++ W + P L SR+ Sbjct: 242 ---QGRRLLQPEYCPDPLYEVMLKCWH--PKAEMRPSFSELVSRI 281 >3V5Q-A nrPDB Length = 297 Score = 179 bits (455), Expect = 2e-45, Method: Composition-based stats. Identities = 57/302 (18%), Positives = 106/302 (35%), Gaps = 62/302 (20%) Query: 58 DTKVIGNGSFGVVYQAKL-----CDSGELVAIKKVLQ----DKRFKNRELQIMRKLDHCN 108 + +G G+FG V+ A+ LVA+K + ++ RE +++ L H + Sbjct: 19 LKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEH 78 Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYR-------------VARHYSRAKQTLPV 155 IV+ D L +V +Y+ V +AK L + Sbjct: 79 IVKFYGVC------GDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGL 132 Query: 156 IYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVS 215 + Q+ + Y+ S HRD+ +N L+ + ++K+ DFG ++ + + Sbjct: 133 SQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANL-LVKIGDFGMSRDVYSTDYYRV 191 Query: 216 YICS---RYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIK 271 + + PE I +T+ DVWS G +L E+ G+ + S + + I + Sbjct: 192 GGHTMLPIRWMPPESIM-YRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQ 250 Query: 272 VLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTP 331 ++ P P E + + P RL Sbjct: 251 G----------------------RVLERP------RVCPKEVYDVMLGCWQREPQQRLNI 282 Query: 332 LE 333 E Sbjct: 283 KE 284 >2HK5-A nrPDB Length = 270 Score = 179 bits (453), Expect = 2e-45, Method: Composition-based stats. Identities = 60/273 (21%), Positives = 112/273 (41%), Gaps = 32/273 (11%) Query: 49 DRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVL---QDKRFKNRELQIMRKLD 105 + P+E S K +G G FG V+ A + VA+K + E +M+ L Sbjct: 11 EIPRE-SLKLEKKLGAGQFGEVWMATYNKHTK-VAVKTMKPGSMSVEAFLAEANVMKTLQ 68 Query: 106 HCNIVRLRYFFYSSGEKKDEVYLNLVLDYVP-ETVYRVARHYSRAKQTLPVIYVKLYMYQ 164 H +V+L + + ++ +++ ++ + +KQ LP + + Q Sbjct: 69 HDKLVKLHAVV-------TKEPIYIITEFMAKGSLLDFLKSDEGSKQPLP--KLIDFSAQ 119 Query: 165 LFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY--- 221 + +A+I HRD++ N+L+ + V K+ DFG A+ ++ + +++ Sbjct: 120 IAEGMAFIEQRNYIHRDLRAANILVSA-SLVCKIADFGLAR-VIEDNEYTAREGAKFPIK 177 Query: 222 YRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQ 280 + APE I +T DVWS G +L E++ G+ +PG S + + + + Sbjct: 178 WTAPEAI-NFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALER--------G 228 Query: 281 IREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEA 313 R P + I W RP P Sbjct: 229 YRMPRPENCPEELYNIMMRCWKN--RPEERPTF 259 >4NEU-A nrPDB Length = 333 Score = 178 bits (452), Expect = 4e-45, Method: Composition-based stats. Identities = 69/338 (20%), Positives = 121/338 (35%), Gaps = 58/338 (17%) Query: 50 RPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQD------KRFKNRELQIMRK 103 + + + ++ + +G FG V G ++ +K V + E ++M + Sbjct: 20 KMKSSDFLESAELDSGGFGKVSLCFHRTQGLMI-MKTVYKGPNCIEHNEALLEEAKMMNR 78 Query: 104 LDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMY 163 L H +V+L G+ LV++Y+ + H +A+ + P+ + Sbjct: 79 LRHSRVVKLLGVIIEEGKYS------LVMEYMEKGN---LMHVLKAEMSTPLSVKGRIIL 129 Query: 164 QLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSA-----KQLVRGEPN----- 213 ++ + Y+H G+ H+D+KP+N+L+D D +K+ D G A +L E N Sbjct: 130 EIIEGMCYLHGKGVIHKDLKPENILVDNDFH-IKIADLGLASFKMWSKLNNEEHNELREV 188 Query: 214 ----VSYICSRYYRAPELIFGAT-DYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVE 268 + YY APE + T DV+S VL + + + QL+ Sbjct: 189 DGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIM 248 Query: 269 IIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTAR 328 IK P + I E P E I+L E P AR Sbjct: 249 CIKSGNRPDVDDITEYCPR------------------------EIISLMKLCWEANPEAR 284 Query: 329 LTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQE 366 T F ++ D +L + E Sbjct: 285 PTFPGI--EEKFRPFYLSQLEESVEEDVKSLKKEYSNE 320 >1K9A-A nrPDB Length = 450 Score = 178 bits (452), Expect = 4e-45, Method: Composition-based stats. Identities = 59/287 (20%), Positives = 103/287 (35%), Gaps = 46/287 (16%) Query: 57 TDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQD--KRFKNRELQIMRKLDHCNIVRLRY 114 + IG G FG V G VA+K + D + E +M +L H N+V+L Sbjct: 196 KLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLG 253 Query: 115 FFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHS 174 +++ L +V +Y+ + V SR + L + + + ++ Y+ Sbjct: 254 VI-----VEEKGGLYIVTEYMAKGSL-VDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEG 307 Query: 175 FGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDY 234 HRD+ +N+L+ D V K+ DFG K+ + + APE + + Sbjct: 308 NNFVHRDLAARNVLVSEDN-VAKVSDFGLTKEASSTQDTGKLPV--KWTAPEALR-EKKF 363 Query: 235 TSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKF 293 ++ DVWS G +L E+ G+ +P P ++ + + Y + Sbjct: 364 STKSDVWSFGILLWEIYSFGRVPYP---------------RIPLKDVVPRVEKGY-KMDA 407 Query: 294 PQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLT---PLEACAH 337 P PP + R T E H Sbjct: 408 PD------------GCPPAVYDVMKNCWHLDAATRPTFLQLREQLEH 442 >3C1X-A nrPDB Length = 373 Score = 178 bits (452), Expect = 4e-45, Method: Composition-based stats. Identities = 69/318 (21%), Positives = 118/318 (37%), Gaps = 35/318 (11%) Query: 18 QQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCD 77 + F + +V P + +VIG G FG VY L D Sbjct: 53 SENLYFQGANTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLD 112 Query: 78 S-GELV--AIKKVLQ-----DKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLN 129 + G+ + A+K + + + E IM+ H N++ L S Sbjct: 113 NDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSP-----L 167 Query: 130 LVLDYVPETVYRVARHYSRAKQTLP-VIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLL 188 +VL Y+ R++ R + P V + + Q+ + + ++ S HRD+ +N + Sbjct: 168 VVLPYMKHG---DLRNFIRNETHNPTVKDLIGFGLQVAKGMKFLASKKFVHRDLAARNCM 224 Query: 189 LDPDTAVLKLCDFGSAKQLVRGE-----PNVSYICSRYYRAPELIFGATDYTSSIDVWSA 243 LD V K+ DFG A+ + E + A E + +T+ DVWS Sbjct: 225 LDEKFTV-KVADFGLARDMYDKEFDSVHNKTGAKLPVKWMALESL-QTQKFTTKSDVWSF 282 Query: 244 GCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWT 302 G +L EL+ G P +P + D V ++ + R + P Y ++ W Sbjct: 283 GVLLWELMTRGAPPYPDVNTFDITVYLL--------QGRRLLQPEYCPDPLYEVMLKCWH 334 Query: 303 KVFRPRTPPEAIALCSRL 320 + P L SR+ Sbjct: 335 --PKAEMRPSFSELVSRI 350 >1LUF-A nrPDB Length = 343 Score = 178 bits (451), Expect = 4e-45, Method: Composition-based stats. Identities = 60/302 (19%), Positives = 110/302 (36%), Gaps = 54/302 (17%) Query: 57 TDTKVIGNGSFGVVYQAKLC-----DSGELVAIKKVLQD-----KRFKNRELQIMRKLDH 106 + IG G+FG V+QA+ + +VA+K + ++ + RE +M + D+ Sbjct: 50 EYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDN 109 Query: 107 CNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVA---------------------RH 145 NIV+L + L+ +Y+ R Sbjct: 110 PNIVKLLGVCAVGKP------MCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRARV 163 Query: 146 YSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAK 205 S L Q+ +AY+ HRD+ +N L+ + V+K+ DFG ++ Sbjct: 164 SSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENM-VVKIADFGLSR 222 Query: 206 QLVRGEPNVSYICSR---YYRAPELIFGATDYTSSIDVWSAGCVLAELL-LGQPIFPGDS 261 + + + + PE IF YT+ DVW+ G VL E+ G + G + Sbjct: 223 NIYSADYYKADGNDAIPIRWMPPESIF-YNRYTTESDVWAYGVVLWEIFSYGLQPYYGMA 281 Query: 262 GVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLL 321 + + + R+ P + + W+K+ P P + R+L Sbjct: 282 HEEVIYYV--------RDGNILACPENCPLELYNLMRLCWSKL--PADRPSFCS-IHRIL 330 Query: 322 EY 323 + Sbjct: 331 QR 332 >2RIO-A nrPDB Length = 434 Score = 178 bits (451), Expect = 4e-45, Method: Composition-based stats. Identities = 75/349 (21%), Positives = 137/349 (39%), Gaps = 72/349 (20%) Query: 60 KVIGNGSFGVV-YQAKLCDSGELVAIKKVLQD-KRFKNRELQIMRKLD-HCNIVRLRYFF 116 K++G GS G V +Q G VA+K++L D E++++ + D H N++R Sbjct: 21 KILGYGSSGTVVFQGSFQ--GRPVAVKRMLIDFCDIALMEIKLLTESDDHPNVIRYY--- 75 Query: 117 YSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLP---VIYVKLYMYQLFRSLAYIH 173 + + +L + L+ + + + + + L + Q+ +A++H Sbjct: 76 ---CSETTDRFLYIALELCNLNLQDLVESKNVSDENLKLQKEYNPISLLRQIASGVAHLH 132 Query: 174 SFGICHRDIKPQNLLLDP------------DTAVLKLCDFGSAKQLVRGEPNVSY----- 216 S I HRD+KPQN+L+ + + + DFG K+L G+ + Sbjct: 133 SLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRTNLNNP 192 Query: 217 ICSRYYRAPELIFG------ATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEI 269 + +RAPEL+ T SID++S GCV +L G+ F Sbjct: 193 SGTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPF------------ 240 Query: 270 IKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARL 329 + RE N F ++K + EA L S+++++ P R Sbjct: 241 -------GDKYSRESNIIRGIFSLDEMKC-----LHDRSLIAEATDLISQMIDHDPLKRP 288 Query: 330 TPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQ-ELSSNPPLATIL 377 T ++ H F P + L + + E+ + P + +L Sbjct: 289 TAMKVLRHPLF---------WPKSKKLEFLLKVSDRLEIENRDPPSALL 328 >4XLV-A nrPDB Length = 328 Score = 178 bits (451), Expect = 5e-45, Method: Composition-based stats. Identities = 60/314 (19%), Positives = 108/314 (34%), Gaps = 63/314 (20%) Query: 57 TDTKVIGNGSFGVVYQ--AKLCDSGE---LVAIKKVLQDKRFKNR-----ELQIMRKLDH 106 T + +G GSFG+VY+ A+ GE VA+K V + + R E +M+ Sbjct: 42 TLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTC 101 Query: 107 CNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSR-------AKQTLPVIYVK 159 ++VRL +V++ + + R + + + Sbjct: 102 HHVVRLLGVVSKGQPTL------VVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMI 155 Query: 160 LYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICS 219 ++ +AY+++ HRD+ +N ++ D V K+ DFG + + + Sbjct: 156 QMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTV-KIGDFGMTRDIYETDYYRKGGKG 214 Query: 220 R---YYRAPELIFGATDYTSSIDVWSAGCVLAELLLG-QPIFPGDSGVDQLVEIIKVLGT 275 + APE + +T+S D+WS G VL E+ + + G S L ++ Sbjct: 215 LLPVRWMAPESLKD-GVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYL 273 Query: 276 PTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEAC 335 + P L ++ P R T LE Sbjct: 274 DQPD----------------------------NCPERVTDLMRMCWQFNPNMRPTFLEIV 305 Query: 336 A------HSFFDEL 343 H F E+ Sbjct: 306 NLLKDDLHPSFPEV 319 >5KMM-A nrPDB Length = 329 Score = 177 bits (450), Expect = 6e-45, Method: Composition-based stats. Identities = 63/307 (20%), Positives = 110/307 (35%), Gaps = 63/307 (20%) Query: 62 IGNGSFGVVYQAKLCD-----SGELVAIKKVLQD----KRFKNRELQIMRKLDHCNIVRL 112 +G G+FG V+ A+ + LVA+K + + ++ RE +++ L H +IVR Sbjct: 43 LGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRF 102 Query: 113 RYFFYSSGEKKDEVYLNLVLDYVP-ETVYRVARHYS-----------RAKQTLPVIYVKL 160 L +V +Y+ + R R + A L + + Sbjct: 103 FGVCTEGRP------LLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLA 156 Query: 161 YMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICS- 219 Q+ + Y+ HRD+ +N L+ V+K+ DFG ++ + + + Sbjct: 157 VASQVAAGMVYLAGLHFVHRDLATRNCLVGQ-GLVVKIGDFGMSRDIYSTDYYRVGGRTM 215 Query: 220 --RYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTP 276 + PE I +T+ DVWS G VL E+ G+ + S + + I T Sbjct: 216 LPIRWMPPESIL-YRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCI-----TQ 269 Query: 277 TREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACA 336 RE R PPE A+ + P R + + Sbjct: 270 GRELER-----------------------PRACPPEVYAIMRGCWQREPQQRHSIKDV-- 304 Query: 337 HSFFDEL 343 H+ L Sbjct: 305 HARLQAL 311 >3ZBF-A nrPDB Length = 322 Score = 177 bits (450), Expect = 6e-45, Method: Composition-based stats. Identities = 57/293 (19%), Positives = 108/293 (36%), Gaps = 58/293 (19%) Query: 61 VIGNGSFGVVYQAKLCD-----SGEL-VAIKKVLQ-----DKRFKNRELQIMRKLDHCNI 109 ++G+G+FG VY+ D SGE+ VA+K + + +K +E +M K +H NI Sbjct: 40 LLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNI 99 Query: 110 VRLRYFFYSSGEKKDEVYLNLVLDYVPETVY----RVARHYSRAKQTLPVIYVKLYMYQL 165 ++ + + ++L+ + R AR + L ++ + + Sbjct: 100 LKQLGVCLLNEPQ------YIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDI 153 Query: 166 FRSLAYIHSFGICHRDIKPQNLLLDPDT----AVLKLCDFGSAKQLVRGEPNVSYICSR- 220 + Y+ HRD+ +N L+ ++K+ DFG A+ + + + Sbjct: 154 SKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLL 213 Query: 221 --YYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPT 277 + APE + +T+ DVWS G ++ E+L G +P S +D L + Sbjct: 214 PVRWMAPESLMD-GIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEP 272 Query: 278 REQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLT 330 P + L ++ P R T Sbjct: 273 P----------------------------RNCPDDLWNLMTQCWAQEPDQRPT 297 >1AD5-A nrPDB Length = 438 Score = 177 bits (448), Expect = 1e-44, Method: Composition-based stats. Identities = 67/319 (21%), Positives = 124/319 (38%), Gaps = 54/319 (16%) Query: 16 PVQQPSAFGSMK--VSRDKDGSK-VTTVVATP--GQGPDRPQE--------VSYTDTKVI 62 + S F +++ V K G+ + ++ P P +P E S K + Sbjct: 131 YISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQKPWEKDAWEIPRESLKLEKKL 190 Query: 63 GNGSFGVVYQAKLCDSGELVAIKKVL---QDKRFKNRELQIMRKLDHCNIVRLRYFFYSS 119 G G FG V+ A + VA+K + E +M+ L H +V+L Sbjct: 191 GAGQFGEVWMATYNKHTK-VAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKLHAVV--- 246 Query: 120 GEKKDEVYLNLVLDYVP-ETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGIC 178 + + ++ +++ ++ + +KQ LP + + Q+ +A+I Sbjct: 247 ----TKEPIYIITEFMAKGSLLDFLKSDEGSKQPLP--KLIDFSAQIAEGMAFIEQRNYI 300 Query: 179 HRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY---YRAPELIFGATDYT 235 HRD++ N+L+ + V K+ DFG A+ + +++ + APE I +T Sbjct: 301 HRDLRAANILVSA-SLVCKIADFGLAR-----------VGAKFPIKWTAPEAI-NFGSFT 347 Query: 236 SSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFP 294 DVWS G +L E++ G+ +PG S + + + + R P + Sbjct: 348 IKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALER--------GYRMPRPENCPEELY 399 Query: 295 QIKAHPWTKVFRPRTPPEA 313 I W RP P Sbjct: 400 NIMMRCWKN--RPEERPTF 416 >4IDT-A nrPDB Length = 356 Score = 176 bits (447), Expect = 1e-44, Method: Composition-based stats. Identities = 70/337 (20%), Positives = 117/337 (34%), Gaps = 73/337 (21%) Query: 49 DRPQEVSYTDTKV---------IGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQ 99 ++ + V Y + +G GSFG V++ + +G A+KKV + F+ EL Sbjct: 60 EKLKPVDYEYREEVHWATHQLRLGRGSFGEVHRMEDKQTGFQCAVKKVRLE-VFRAEELM 118 Query: 100 IMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVK 159 L IV L ++ ++N+ ++ + + + LP Sbjct: 119 ACAGLTSPRIVPLYGAV------REGPWVNIFMELLEGGS---LGQLVKEQGCLPEDRAL 169 Query: 160 LYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYI-- 217 Y+ Q L Y+HS I H D+K N+LL D + LCDFG A L + Sbjct: 170 YYLGQALEGLEYLHSRRILHGDVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKDLLTG 229 Query: 218 ----CSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPI----FPGDSGVDQLVEI 269 + + APE++ G + + +DVWS+ C++ +L G F G Sbjct: 230 DYIPGTETHMAPEVVLGRS-CDAKVDVWSSCCMMLHMLNGCHPWTQFFRG-------PLC 281 Query: 270 IKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARL 329 +K+ P P + P P L P R+ Sbjct: 282 LKIASEP-----------------------PPVREIPPSCAPLTAQAIQEGLRKEPIHRV 318 Query: 330 TPLEA-------------CAHSFFDELRDPNVKLPNG 353 + E + E ++P PN Sbjct: 319 SAAELGGKVNRALQQVGGLKSPWRGEYKEPRHPPPNQ 355 >6HV0-A nrPDB Length = 416 Score = 176 bits (447), Expect = 1e-44, Method: Composition-based stats. Identities = 71/304 (23%), Positives = 123/304 (40%), Gaps = 55/304 (18%) Query: 53 EVSYTDTKVIGNGSFGV-VYQAKLCDSGELVAIKKVLQDK-RFKNRELQIMRKLD-HCNI 109 ++S+ V+G+G+ G VY+ VA+K++L + F +RE+Q++R+ D H N+ Sbjct: 7 KISFCPKDVLGHGAEGTIVYRG--MFDNRDVAVKRILPECFSFADREVQLLRESDEHPNV 64 Query: 110 VRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 169 +R +KD + + ++ T+ A L I + + Q L Sbjct: 65 IRYF------CTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITL---LQQTTSGL 115 Query: 170 AYIHSFGICHRDIKPQNLLLDPDTAVLK----LCDFGSAKQLVRGEPNVSY----ICSRY 221 A++HS I HRD+KP N+L+ A K + DFG K+L G + S + Sbjct: 116 AHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEG 175 Query: 222 YRAPELIFG--ATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTR 278 + APE++ + T ++D++SAGCV ++ G F G S Q ++ Sbjct: 176 WIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPF-GKSLQRQANILLGACSLDC- 233 Query: 279 EQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPE--AIALCSRLLEYTPTARLTPLEACA 336 P + A L +++ P R + Sbjct: 234 --------------------------LHPEKHEDVIARELIEKMIAMDPQKRPSAKHVLK 267 Query: 337 HSFF 340 H FF Sbjct: 268 HPFF 271 >1BYG-A nrPDB Length = 278 Score = 176 bits (446), Expect = 2e-44, Method: Composition-based stats. Identities = 57/267 (21%), Positives = 104/267 (38%), Gaps = 25/267 (9%) Query: 57 TDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQD--KRFKNRELQIMRKLDHCNIVRLRY 114 + IG G FG V G VA+K + D + E +M +L H N+V+L Sbjct: 24 KLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLG 81 Query: 115 FFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHS 174 +++ L +V +Y+ + V SR + L + + + ++ Y+ Sbjct: 82 VI-----VEEKGGLYIVTEYMAKGSL-VDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEG 135 Query: 175 FGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDY 234 HRD+ +N+L+ D V K+ DFG K+ + + APE + + Sbjct: 136 NNFVHRDLAARNVLVSEDN-VAKVSDFGLTKEASSTQDTGKLPV--KWTAPEALR-EKKF 191 Query: 235 TSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKF 293 ++ DVWS G +L E+ G+ +P D + + K + P+ Sbjct: 192 STKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEK--------GYKMDAPDGCPPAV 243 Query: 294 PQIKAHPWTKVFRPRTPPEAIALCSRL 320 ++ + W P + L +L Sbjct: 244 YEVMKNCWH--LDAAMRPSFLQLREQL 268 >4TPT-A nrPDB Length = 303 Score = 175 bits (445), Expect = 2e-44, Method: Composition-based stats. Identities = 49/218 (22%), Positives = 100/218 (45%), Gaps = 36/218 (16%) Query: 59 TKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNR----ELQIMRKLDHCNIVRLRY 114 +V+G G FG + +G+++ +K++++ + E+++MR LDH N+++ Sbjct: 5 GEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIG 64 Query: 115 FFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHS 174 Y + LNL+ +Y+ + + R+ P + + +AY+HS Sbjct: 65 VLYK------DKKLNLLTEYIEGGT---LKDFLRSMDPFPWQQKVRFAKGIASGMAYLHS 115 Query: 175 FGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRG---------------------EPN 213 I HRD+ N L+ D V+ + DFG ++ +V + Sbjct: 116 MCIIHRDLNSHNCLIKLDKTVV-VADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKR 174 Query: 214 VSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELL 251 + + + Y+ APE++ G + Y ++D++S G VL E++ Sbjct: 175 YTVVGNPYWMAPEMLNGKS-YDETVDIFSFGIVLCEII 211 >4F0G-A nrPDB Length = 287 Score = 175 bits (445), Expect = 2e-44, Method: Composition-based stats. Identities = 65/286 (22%), Positives = 112/286 (39%), Gaps = 39/286 (13%) Query: 53 EVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIK-----------KVLQDKRFKNRELQIM 101 E+ Y K IG G FG+V++ +L +VAIK ++++ + RE+ IM Sbjct: 20 EIEYE--KQIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQREVFIM 77 Query: 102 RKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLY 161 L+H NIV+L ++ +V+++VP + + Sbjct: 78 SNLNHPNIVKLYGLMHNPPR--------MVMEFVPCG--DLYHRLLDKAHPIKWSVKLRL 127 Query: 162 MYQLFRSLAYIHSFG--ICHRDIKPQNLL---LDPDTAVL-KLCDFGSAKQLVRGEPNVS 215 M + + Y+ + I HRD++ N+ LD + V K+ DFG ++Q V Sbjct: 128 MLDIALGIEYMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQSVHSVS--G 185 Query: 216 YICSRYYRAPELI-FGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLG 274 + + + APE I YT D +S +L +L G+ F S IK + Sbjct: 186 LLGNFQWMAPETIGAEEESYTEKADTYSFAMILYTILTGEGPFDEYS-----YGKIKFIN 240 Query: 275 TPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRL 320 E +R P + + W+ P+ P + L Sbjct: 241 MIREEGLRPTIPEDCPPRLRNVIELCWS--GDPKKRPHFSYIVKEL 284 >4PL5-B nrPDB Length = 435 Score = 175 bits (445), Expect = 3e-44, Method: Composition-based stats. Identities = 70/302 (23%), Positives = 122/302 (40%), Gaps = 51/302 (16%) Query: 53 EVSYTDTKVIGNGSFGV-VYQAKLCDSGELVAIKKVLQDK-RFKNRELQIMRKLD-HCNI 109 ++S+ V+G+G+ G VY+ VA+K++L + F +RE+Q++R+ D H N+ Sbjct: 26 KISFCPKDVLGHGAEGTIVYKG--MFDNRDVAVKRILPECFSFADREVQLLRESDEHPNV 83 Query: 110 VRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 169 +R +KD + + ++ T+ A L I + ++Q L Sbjct: 84 IRYF------CTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITL---LHQTTSGL 134 Query: 170 AYIHSFGICHRDIKPQNLLLDPDT--AVLK--LCDFGSAKQLVRGEPNVSY----ICSRY 221 A++HS I HRD+KP N+LL +K + DFG K+L G + S + Sbjct: 135 AHLHSLNIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEG 194 Query: 222 YRAPELIFG--ATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTR 278 + APE++ + T ++D++SAGCV ++ G F G S Q ++ Sbjct: 195 WIAPEMLSEDCKDNPTYTVDIFSAGCVFYYVISEGYHPF-GKSLQRQANILLGACNLDCF 253 Query: 279 EQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHS 338 A L +++ P R + H Sbjct: 254 HS-------------------------DKHEDVIARELIEKMIAMDPQQRPSAKHVLKHP 288 Query: 339 FF 340 FF Sbjct: 289 FF 290 >5TOS-A nrPDB Length = 395 Score = 174 bits (442), Expect = 4e-44, Method: Composition-based stats. Identities = 71/323 (21%), Positives = 133/323 (41%), Gaps = 45/323 (13%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCD---------SGELVAIKKVLQD----KRFKNRELQIM 101 ++ VIG G FG V++ L + +G ++A+KK+ Q+ R E+ + Sbjct: 66 NFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYL 125 Query: 102 RKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYV-PETVYRVARHYSRAKQTLPVIYVKL 160 +L H N+V+L + ++ + LV +++ ++ + LP Sbjct: 126 GQLSHPNLVKLIGYCL------EDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVN 179 Query: 161 YMYQLFRSLAYIHSF--GICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGE---PNVS 215 + LA++HS + +RDIK N+LLD D KL DFG A+ G+ + Sbjct: 180 VALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNA-KLSDFGLARDGPMGDLSYVSTR 238 Query: 216 YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSG--VDQLVEIIKVL 273 + + Y APE + + DV+S G +L E+L G+ + + LV+ + Sbjct: 239 VMGTYGYAAPE-YMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPY 297 Query: 274 GTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLE 333 T R+ + ++ P+ R A+ + L + P +R T + Sbjct: 298 LTSKRKVLLIVDNRLDTQYLPE---------EAVRMASVAV----QCLSFEPKSRPTMDQ 344 Query: 334 ACAHSFFDELRDPNVKLPNGRDT 356 +L+D N+ P+ + Sbjct: 345 VVRA--LQQLQD-NLGKPSQTNP 364 >6FEX-A nrPDB Length = 321 Score = 173 bits (438), Expect = 1e-43, Method: Composition-based stats. Identities = 63/308 (20%), Positives = 109/308 (35%), Gaps = 50/308 (16%) Query: 44 PGQGPDRPQEVSY-----TDTKVIGNGSFGVVYQAK--------------LCDSGE--LV 82 PG D P V + + +G G FG V+ + G LV Sbjct: 1 PGAVGDGPPRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLV 60 Query: 83 AIKKVLQDKRFKNR-----ELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPE 137 A+K + D R E++IM +L NI+RL L ++ DY+ Sbjct: 61 AVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDP------LCMITDYMEN 114 Query: 138 T----------VYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNL 187 + A + T+ + Q+ + Y+ + HRD+ +N Sbjct: 115 GDLNQFLSAHQLEDKAAEGAPGDPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNC 174 Query: 188 LLDPDTAVLKLCDFGSAKQLVRGEPNVSY---ICSRYYRAPELIFGATDYTSSIDVWSAG 244 L+ + +K+ DFG ++ L G+ + + A E I +T++ DVW+ G Sbjct: 175 LVGENFT-IKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECIL-MGKFTTASDVWAFG 232 Query: 245 CVLAE--LLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWT 302 L E +L F G +Q++E Q+ P ++ W+ Sbjct: 233 VTLWEVLMLCRAQPF-GQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWS 291 Query: 303 KVFRPRTP 310 + R P Sbjct: 292 RESEQRPP 299 >4Y83-A nrPDB Length = 332 Score = 171 bits (433), Expect = 5e-43, Method: Composition-based stats. Identities = 59/291 (20%), Positives = 103/291 (35%), Gaps = 38/291 (13%) Query: 51 PQEVSYTDT--KVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCN 108 P +++Y + I G+FG VY A+ + + +A K + D +FK +++I H N Sbjct: 68 PWKLTYRNIGSDFIPRGAFGKVYLAQDIKTKKRMACKLIPVD-QFKPSDVEIQACFRHEN 126 Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRS 168 I L GE ++L ++ + + + + + Sbjct: 127 IAELYGAVL-WGET-----VHLFMEAGEGGS---VLEKLESCGPMREFEIIWVTKHVLKG 177 Query: 169 LAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPN-VSYICSRYYRAPEL 227 L ++HS + H DIKP N++ AV L DFG + Q+ + Y +PE+ Sbjct: 178 LDFLHSKKVIHHDIKPSNIVFMSTKAV--LVDFGLSVQMTEDVYFPKDLRGTEIYMSPEV 235 Query: 228 IFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPN 287 I +++ D++S G L + G P + R Sbjct: 236 IL-CRGHSTKADIYSLGATLIHMQTGTPPW----------------------VKRYPRSA 272 Query: 288 YTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHS 338 Y + + K P + P L LE P R + H Sbjct: 273 YPSYLYIIHKQAPPLEDIADDCSPGMRELIEASLERNPNHRPRAADLLKHE 323 >3PLS-A nrPDB Length = 298 Score = 170 bits (432), Expect = 7e-43, Method: Composition-based stats. Identities = 67/286 (23%), Positives = 104/286 (36%), Gaps = 53/286 (18%) Query: 60 KVIGNGSFGVVYQAKLCDSGE---LVAIKKV-----LQDKRFKNRELQIMRKLDHCNIVR 111 +VIG G FGVVY + D + AIK + +Q RE +MR L+H N++ Sbjct: 27 RVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLNHPNVLA 86 Query: 112 LRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAY 171 L + + + + R R V + + Q+ R + Y Sbjct: 87 LIGIMLPPEGLPHVLLPYM----CHGDLLQFIRSPQRNP---TVKDLISFGLQVARGMEY 139 Query: 172 IHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY------YRAP 225 + HRD+ +N +LD ++ +K+ DFG A+ ++ E S R+ + A Sbjct: 140 LAEQKFVHRDLAARNCMLD-ESFTVKVADFGLARDILDRE-YYSVQQHRHARLPVKWTAL 197 Query: 226 ELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREM 284 E + +T+ DVWS G +L ELL G P + D L + R Sbjct: 198 ESLQTYR-FTTKSDVWSFGVLLWELLTRGAPPYRHIDPFD--------LTHFLAQGRRLP 248 Query: 285 NPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLT 330 P Y Q+ W E P R T Sbjct: 249 QPEYCPDSLYQVMQQCW--------------------EADPAVRPT 274 >6BSD-A nrPDB Length = 876 Score = 170 bits (432), Expect = 8e-43, Method: Composition-based stats. Identities = 63/325 (19%), Positives = 110/325 (33%), Gaps = 56/325 (17%) Query: 33 DGSKVTTVVATPGQGPDRPQEVSY-----TDTKVIGNGSFGVVYQAK------------- 74 G+ PG D P V + + +G G FG V+ + Sbjct: 545 GGNTYAVPALPPGAVGDGPPRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFP 604 Query: 75 -LCDSGE--LVAIKKVLQDKRFKNR-----ELQIMRKLDHCNIVRLRYFFYSSGEKKDEV 126 G LVA+K + D R E++IM +L NI+RL Sbjct: 605 LNVRKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDP----- 659 Query: 127 YLNLVLDYVPETVYRVARHYSRAK----------------QTLPVIYVKLYMYQLFRSLA 170 L ++ DY+ + + T+ + Q+ + Sbjct: 660 -LCMITDYMENGDLNQFLSAHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMR 718 Query: 171 YIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSY---ICSRYYRAPEL 227 Y+ + HRD+ +N L+ + +K+ DFG ++ L G+ + + A E Sbjct: 719 YLATLNFVHRDLATRNCLVGENFT-IKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWEC 777 Query: 228 IFGATDYTSSIDVWSAGCVLAE--LLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMN 285 I +T++ DVW+ G L E +L F G +Q++E Q+ Sbjct: 778 IL-MGKFTTASDVWAFGVTLWEVLMLCRAQPF-GQLTDEQVIENAGEFFRDQGRQVYLSR 835 Query: 286 PNYTEFKFPQIKAHPWTKVFRPRTP 310 P ++ W++ R P Sbjct: 836 PPACPQGLYELMLRCWSRESEQRPP 860 >3AOX-A nrPDB Length = 344 Score = 170 bits (431), Expect = 1e-42, Method: Composition-based stats. Identities = 64/300 (21%), Positives = 111/300 (37%), Gaps = 38/300 (12%) Query: 41 VATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAK-----LCDSGELVAIKKVL-----QD 90 ++ + P++ + T + +G+G+FG VY+ + S VA+K + QD Sbjct: 35 TSSISDLKEVPRK-NITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQD 93 Query: 91 KRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAK 150 + E I+ K +H NIVR G + ++L+ + + +R + Sbjct: 94 ELDFLMEALIISKFNHQNIVR------CIGVSLQSLPRFILLELMAGGDLKSFLRETRPR 147 Query: 151 QT----LPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLD--PDTAVLKLCDFGSA 204 + L ++ + + Y+ HRDI +N LL V K+ DFG A Sbjct: 148 PSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMA 207 Query: 205 KQLVRGEPNVSYICS---RYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGD 260 + + R C+ + PE F +TS D WS G +L E+ G +P Sbjct: 208 RDIYRASYYRKGGCAMLPVKWMPPEA-FMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSK 266 Query: 261 SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRL 320 S + L + R P +I W +P P + R+ Sbjct: 267 SNQEVLEFVTSGG--------RMDPPKNCPGPVYRIMTQCWQH--QPEDRPNFAIILERI 316 >2PMN-X nrPDB Length = 348 Score = 168 bits (426), Expect = 3e-42, Method: Composition-based stats. Identities = 64/316 (20%), Positives = 112/316 (35%), Gaps = 47/316 (14%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNR------------------ 96 Y + + G F + + + A+KK + K R Sbjct: 32 DYRIIRTLNQGKFNKIILCE--KDNKFYALKKYEKSLLEKKRDFTKSNNDKISIKSKYDD 89 Query: 97 ---ELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQT- 152 ELQI+ ++ Y G + + ++ +Y+ Y Sbjct: 90 FKNELQIITD------IKNEYCLTCEGIITNYDEVYIIYEYMENDSILKFDEYFFVLDKN 143 Query: 153 ----LPVIYVKLYMYQLFRSLAYIH-SFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQL 207 +P+ +K + + S +YIH ICHRD+KP N+L+D + V KL DFG ++ + Sbjct: 144 YTCFIPIQVIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMDKNGRV-KLSDFGESEYM 202 Query: 208 VRGEPNVSYICSRYYRAPELIFGATDY-TSSIDVWSAGCVLAELLLGQPIFPGDSGVDQL 266 V + + + PE + Y + +D+WS G L + F S L Sbjct: 203 V-DKKIKGSRGTYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMFYNVVPF---SLKISL 258 Query: 267 VEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPT 326 VE+ + T E ++ N+ + K+ E I L P Sbjct: 259 VELFNNIRTKNIEY--PLDRNHFLYPLTNKKSTCSNNFL----SNEDIDFLKLFLRKNPA 312 Query: 327 ARLTPLEACAHSFFDE 342 R+T +A H + + Sbjct: 313 ERITSEDALKHEWLAD 328 >6J5U-C nrPDB Length = 426 Score = 168 bits (426), Expect = 4e-42, Method: Composition-based stats. Identities = 65/299 (21%), Positives = 113/299 (37%), Gaps = 38/299 (12%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDS---------GELVAIKKVL----QDKRFKNRELQIM 101 ++ ++G G FG V++ + + G +VA+K++ Q + E+ + Sbjct: 85 NFRQDNLLGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQLKPEGFQGHKEWLTEVNYL 144 Query: 102 RKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLY 161 +L H N+V L + + GE + LV +++P+ + R Q L Sbjct: 145 GQLSHPNLVLLVGYC-AEGENR-----LLVYEFMPKGSLE-NHLFRRGAQPLTWAIRMKV 197 Query: 162 MYQLFRSLAYIHSFG--ICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPN---VSY 216 + L ++H + +RD K N+LLD D KL DFG AK G+ Sbjct: 198 AVGAAKGLTFLHEAKSQVIYRDFKAANILLDADFNA-KLSDFGLAKAGPTGDNTHVSTKV 256 Query: 217 ICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTP 276 I + Y APE + T+ DV+S G VL EL+ G+ +G ++ + Sbjct: 257 IGTHGYAAPEYV-ATGRLTAKSDVYSFGVVLLELISGRRAMDNSNGGNEYSLVDWATPYL 315 Query: 277 TREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEAC 335 ++ K +I + + A L + L R E Sbjct: 316 GDKR-----------KLFRIMDTKLGGQYPQKGAFTAANLALQCLNPDAKLRPKMSEVL 363 >4F9B-A nrPDB Length = 361 Score = 168 bits (426), Expect = 4e-42, Method: Composition-based stats. Identities = 77/353 (21%), Positives = 131/353 (37%), Gaps = 81/353 (22%) Query: 56 YTDTKVIGNGSFGVVYQAK---LCDSGELVAIKKVLQDKRFKNRELQIMRKLDH------ 106 + IG G+F VY A E +A+K ++ ++I +L Sbjct: 23 FKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHP----IRIAAELQCLTVAGG 78 Query: 107 -CNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQL 165 N++ ++Y F + ++ + + Y+ + +L V+ YM L Sbjct: 79 QDNVMGVKYCF------RKNDHVVIAMPYLEH------ESFLDILNSLSFQEVREYMLNL 126 Query: 166 FRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ------------------- 206 F++L IH FGI HRD+KP N L + L DFG A+ Sbjct: 127 FKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQE 186 Query: 207 ----------LVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPI 256 L R + + +RAPE++ + T++ID+WSAG + LL G+ Sbjct: 187 RCSQNKCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYP 246 Query: 257 FP-GDSGVDQLVEIIKVLGT-------------------PTREQIREMNPNYTEFKFP-- 294 F + L +I+ + G+ + +R++ Sbjct: 247 FYKASDDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSSTP 306 Query: 295 ----QIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDEL 343 I+ H P EA L +LL+ P +R+T EA H FF ++ Sbjct: 307 KLTSDIQGHATNLEGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFFKDM 359 >4G3E-A nrPDB Length = 352 Score = 167 bits (424), Expect = 6e-42, Method: Composition-based stats. Identities = 62/255 (24%), Positives = 101/255 (39%), Gaps = 18/255 (7%) Query: 9 SFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKV-IGNGSF 67 S A K SA +D V + +EV + + +G GSF Sbjct: 28 SLASLAKTWSSGSAKLQRLGPETEDNEGVLLTEKLKPVDYEYREEVHWMTHQPRVGRGSF 87 Query: 68 GVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVY 127 G V++ K +G A+KKV + F+ EL L IV L ++ + Sbjct: 88 GEVHRMKDKQTGFQCAVKKVRLE-VFRVEELVACAGLSSPRIVPLYGAV------REGPW 140 Query: 128 LNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNL 187 +N+ ++ + + LP Y+ Q L Y+H+ I H D+K N+ Sbjct: 141 VNIFMELLEGGS---LGQLIKQMGCLPEDRALYYLGQALEGLEYLHTRRILHGDVKADNV 197 Query: 188 LLDPDTAVLKLCDFGSAKQLVRGEPNVSYI------CSRYYRAPELIFGATDYTSSIDVW 241 LL D + LCDFG A L S + + + APE++ G + +D+W Sbjct: 198 LLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPEVVMG-KPCDAKVDIW 256 Query: 242 SAGCVLAELLLGQPI 256 S+ C++ +L G Sbjct: 257 SSCCMMLHMLNGCHP 271 >3I81-A nrPDB Length = 315 Score = 167 bits (422), Expect = 1e-41, Method: Composition-based stats. Identities = 59/339 (17%), Positives = 120/339 (35%), Gaps = 65/339 (19%) Query: 57 TDTKVIGNGSFGVVYQAKLC-----DSGELVAIKKVLQDKRFKNR-----ELQIMRKLDH 106 T ++ +G GSFG+VY+ + VAIK V + + R E +M++ + Sbjct: 21 TMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNC 80 Query: 107 CNIVRLRYFFYSSGEKKDEVYLNLVLDYVP----ETVYRVARHYSRAKQTLPVIYVKLYM 162 ++VRL ++++ + ++ R R L + + Sbjct: 81 HHVVRLLGVVSQGQPTL------VIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMI 134 Query: 163 Y---QLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICS 219 ++ +AY+++ HRD+ +N ++ D V K+ DFG + + + Sbjct: 135 QMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTV-KIGDFGMTRDIYETDYYRKGGKG 193 Query: 220 R---YYRAPELIFGATDYTSSIDVWSAGCVLAELLLG-QPIFPGDSGVDQLVEIIKVLGT 275 + +PE + +T+ DVWS G VL E+ + + G S L +++ Sbjct: 194 LLPVRWMSPESLKD-GVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLL 252 Query: 276 PTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEAC 335 + +M L +Y P R + Sbjct: 253 DKPDNCPDML----------------------------FELMRMCWQYNPKMRPS----- 279 Query: 336 AHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLA 374 F + + ++ G + + ++ +NP LA Sbjct: 280 ---FLEIISSIKEEMEPGFREVSFYYSEENKMENNPVLA 315 >3UIM-A nrPDB Length = 326 Score = 167 bits (422), Expect = 1e-41, Method: Composition-based stats. Identities = 70/290 (24%), Positives = 127/290 (43%), Gaps = 29/290 (10%) Query: 54 VSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKR-----FKNRELQIMRKLDHCN 108 ++++ ++G G FG VY+ +L D G LVA+K++ +++ E++++ H N Sbjct: 30 DNFSNKNILGRGGFGKVYKGRLAD-GTLVAVKRLKEERTQGGELQFQTEVEMISMAVHRN 88 Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVPET-VYRVARHYSRAKQTLPVIYVKLYMYQLFR 167 ++RLR F + E+ LV Y+ V R ++ L + R Sbjct: 89 LLRLRGFCMTPTERL------LVYPYMANGSVASCLRERPESQPPLDWPKRQRIALGSAR 142 Query: 168 SLAYIHSF---GICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYI--CSRYY 222 LAY+H I HRD+K N+LLD + + + DFG AK + + +V+ + + Sbjct: 143 GLAYLHDHCDPKIIHRDVKAANILLDEEFEAV-VGDFGLAKLMDYKDTHVTTAVRGTIGH 201 Query: 223 RAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFP----GDSGVDQLVEIIKVLGTPTR 278 APE + + DV+ G +L EL+ GQ F + L++ +K L + Sbjct: 202 IAPEYL-STGKSSEKTDVFGYGVMLLELITGQRAFDLARLANDDDVMLLDWVKGLLKEKK 260 Query: 279 EQIR---EMNPNYTEFKFPQIKAHPWT-KVFRPRTPPEAIALCSRLLEYT 324 + ++ NY + + Q+ P P+ + R+LE Sbjct: 261 LEALVDVDLQGNYKDEEVEQLIQVALLCTQSSPMERPKMSEVV-RMLEGD 309 >6FER-A nrPDB Length = 309 Score = 167 bits (422), Expect = 1e-41, Method: Composition-based stats. Identities = 61/302 (20%), Positives = 112/302 (37%), Gaps = 50/302 (16%) Query: 57 TDTKVIGNGSFGVVYQAK--------------LCDSGE--LVAIKKVLQDKRFKNR---- 96 T + +G G FG V+ + + + LVA+K + D R Sbjct: 12 TFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFL 71 Query: 97 -ELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAK----- 150 E++IM +L NI+ L + L ++ +Y+ Sbjct: 72 KEIKIMSRLKDPNIIHLLAVCITDDP------LCMITEYMENGDLNQFLSRHEPPNSSSS 125 Query: 151 --QTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLV 208 +T+ +K Q+ + Y+ S HRD+ +N L+ + +K+ DFG ++ L Sbjct: 126 DVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKN-YTIKIADFGMSRNLY 184 Query: 209 RGEPNV---SYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQ 265 G+ + + + E I +T++ DVW+ G L E F + Q Sbjct: 185 SGDYYRIQGRAVLPIRWMSWESIL-LGKFTTASDVWAFGVTLWETFT----FCQEQPYSQ 239 Query: 266 L--VEIIKVLGTPTREQIREM---NPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRL 320 L ++I+ G R+Q R+ P ++ W + + R + I L L Sbjct: 240 LSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIHLL--L 297 Query: 321 LE 322 L+ Sbjct: 298 LQ 299 >5TE0-A nrPDB Length = 347 Score = 166 bits (421), Expect = 1e-41, Method: Composition-based stats. Identities = 73/334 (21%), Positives = 123/334 (36%), Gaps = 57/334 (17%) Query: 57 TDTKVIGNGSFGVVYQAKLCDSGELVAIKKVL----QDKRFKNRELQIMRKLD-HCNIVR 111 T +V+ G F +V+ + +G A+K++ D + RE+QIMR L H NIV Sbjct: 22 TVDEVLAEGGFAIVFLVR-TSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVG 80 Query: 112 LRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAY 171 ++ D + +++D+ + R + V ++A Sbjct: 81 YIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMN-QRLQTGFTENEVLQIFCDTCEAVAR 139 Query: 172 IHSFG--ICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRG---------EPNVSYICSR 220 +H I HRD+K +N+LL D LCDFGSA + E + + Sbjct: 140 LHQCKTPIIHRDLKVENILL-HDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTL 198 Query: 221 YYRAPEL--IFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTR 278 YRAPE+ ++ T+ D+W+ GC+L +L F G+S Sbjct: 199 SYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPF-GES----------------- 240 Query: 279 EQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHS 338 ++ F P R + L +LE P R + S Sbjct: 241 ----QVAICDGNFTIPD----------NSRYSQDMHCLIRYMLEPDPDKRPDIYQV---S 283 Query: 339 FFD-ELRDPNVKLPNGRDTPALFNFTTQELSSNP 371 +F +L +PN +++P +S Sbjct: 284 YFSFKLLKKECPIPNVQNSPIPAKLPEPVKASEA 317 >5LPZ-A nrPDB Length = 332 Score = 166 bits (421), Expect = 2e-41, Method: Composition-based stats. Identities = 61/212 (28%), Positives = 99/212 (46%), Gaps = 20/212 (9%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVL----QDKRFKNRELQIMRKLDHCNIVR 111 + + +IG+G FG VY+A L D G VAIKK++ Q R E++ + K+ H N+V Sbjct: 19 FHNDSLIGSGGFGDVYKAILKD-GSAVAIKKLIHVSGQGDREFMAEMETIGKIKHRNLVP 77 Query: 112 LRYFFYSSGEKKDEVYLNLVLDYVP-ETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLA 170 L + E+ LV +++ ++ V +A L + R LA Sbjct: 78 LLGYCKVGDERL------LVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLA 131 Query: 171 YIHSF---GICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSY---ICSRYYRA 224 ++H I HRD+K N+LLD + ++ DFG A+ + + ++S + Y Sbjct: 132 FLHHNCSPHIIHRDMKSSNVLLDENLEA-RVSDFGMARLMSAMDTHLSVSTLAGTPGYVP 190 Query: 225 PELIFGATDYTSSIDVWSAGCVLAELLLGQPI 256 PE ++ DV+S G VL ELL G+ Sbjct: 191 PEYYQSFR-CSTKGDVYSYGVVLLELLTGKRP 221 >5LPV-A nrPDB Length = 296 Score = 166 bits (420), Expect = 2e-41, Method: Composition-based stats. Identities = 61/212 (28%), Positives = 99/212 (46%), Gaps = 20/212 (9%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVL----QDKRFKNRELQIMRKLDHCNIVR 111 + + +IG+G FG VY+A L D G VAIKK++ Q R E++ + K+ H N+V Sbjct: 19 FHNDSLIGSGGFGDVYKAILKD-GSAVAIKKLIHVSGQGDREFMAEMETIGKIKHRNLVP 77 Query: 112 LRYFFYSSGEKKDEVYLNLVLDYVP-ETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLA 170 L + E+ LV +++ ++ V +A L + R LA Sbjct: 78 LLGYCKVGDERL------LVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLA 131 Query: 171 YIHSF---GICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSY---ICSRYYRA 224 ++H I HRD+K N+LLD + ++ DFG A+ + + ++S + Y Sbjct: 132 FLHHNCSPHIIHRDMKSSNVLLDENLEA-RVSDFGMARLMSAMDTHLSVSTLAGTPGYVP 190 Query: 225 PELIFGATDYTSSIDVWSAGCVLAELLLGQPI 256 PE ++ DV+S G VL ELL G+ Sbjct: 191 PEYYQSFR-CSTKGDVYSYGVVLLELLTGKRP 221 >3QD2-B nrPDB Length = 332 Score = 164 bits (416), Expect = 5e-41, Method: Composition-based stats. Identities = 60/335 (17%), Positives = 115/335 (34%), Gaps = 83/335 (24%) Query: 54 VSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ-----DKRFKNRELQIMRKLDHCN 108 + + +G G FGVV++AK AIK++ + RE++ + KL+H Sbjct: 6 TDFEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPG 65 Query: 109 IVRLRYFFYSSGEKK--------------------------------------------- 123 IVR + + +K Sbjct: 66 IVRYFNAWLETPPEKWQEEMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFSTKNTVG 125 Query: 124 ------DEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGI 177 +VYL + + + + + + + Q+ ++ ++HS G+ Sbjct: 126 QLQPSSPKVYLYIQMQLCRKENLKDWMNRRCSLEDREHGVCLHIFIQIAEAVEFLHSKGL 185 Query: 178 CHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEP-------------NVSYICSRYYRA 224 HRD+KP N+ D V+K+ DFG + + E + + ++ Y + Sbjct: 186 MHRDLKPSNIFFTMDD-VVKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQVGTKLYMS 244 Query: 225 PELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREM 284 PE I G +Y+ +D++S G +L ELL + + ++++ I V + Sbjct: 245 PEQIHG-NNYSHKVDIFSLGLILFELL-----YSFSTQMERVRIITDVRNLKFPLLFTQK 298 Query: 285 NPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSR 319 P + P PEA + Sbjct: 299 YPQ-------EHMMVQDMLSPSPTERPEATDIIEN 326 >6B2Q-A nrPDB Length = 317 Score = 164 bits (415), Expect = 6e-41, Method: Composition-based stats. Identities = 63/227 (27%), Positives = 100/227 (44%), Gaps = 17/227 (7%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ----DKRFKNR---ELQIMRKLDHC 107 Y ++I G G V++A G VA+K + D F R E + L+H Sbjct: 33 RYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHP 92 Query: 108 NIVRLRYFFYSSGEKKDEVYLNLVLDYV-PETVYRVARHYSRAKQTLPVIYVKLYMYQLF 166 I + + S + LV++ V E + V + R L + + + Q Sbjct: 93 GIASVHDYGESQMNGEGRTA-YLVMELVNGEPLNSVLKRTGR----LSLRHALDMLEQTG 147 Query: 167 RSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVS--YICSRYYRA 224 R+L H+ G+ HRD+KP N+L+ P V K+ DFG AK + + + + Y A Sbjct: 148 RALQIAHAAGLVHRDVKPGNILITPTGQV-KITDFGIAKAVDAAPVTQTGMVMGTAQYIA 206 Query: 225 PELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIK 271 PE G D + + DV+S G V E + G+ F GD + ++ IK Sbjct: 207 PEQALGH-DASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIK 252 >4X3F-A nrPDB Length = 337 Score = 164 bits (415), Expect = 6e-41, Method: Composition-based stats. Identities = 63/227 (27%), Positives = 100/227 (44%), Gaps = 17/227 (7%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ----DKRFKNR---ELQIMRKLDHC 107 Y ++I G G V++A G VA+K + D F R E + L+H Sbjct: 13 RYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHP 72 Query: 108 NIVRLRYFFYSSGEKKDEVYLNLVLDYV-PETVYRVARHYSRAKQTLPVIYVKLYMYQLF 166 I + + S + LV++ V E + V + R L + + + Q Sbjct: 73 GIASVHDYGESQMNGEGRTA-YLVMELVNGEPLNSVLKRTGR----LSLRHALDMLEQTG 127 Query: 167 RSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVS--YICSRYYRA 224 R+L H+ G+ HRD+KP N+L+ P V K+ DFG AK + + + + Y A Sbjct: 128 RALQIAHAAGLVHRDVKPGNILITPTGQV-KITDFGIAKAVDAAPVTQTGMVMGTAQYIA 186 Query: 225 PELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIK 271 PE G D + + DV+S G V E + G+ F GD + ++ IK Sbjct: 187 PEQALGH-DASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIK 232 >4OW8-A nrPDB Length = 283 Score = 164 bits (415), Expect = 6e-41, Method: Composition-based stats. Identities = 63/227 (27%), Positives = 100/227 (44%), Gaps = 17/227 (7%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ----DKRFKNR---ELQIMRKLDHC 107 Y ++I G G V++A G VA+K + D F R E + L+H Sbjct: 12 RYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHP 71 Query: 108 NIVRLRYFFYSSGEKKDEVYLNLVLDYV-PETVYRVARHYSRAKQTLPVIYVKLYMYQLF 166 I + + S + LV++ V E + V + R L + + + Q Sbjct: 72 GIASVHDYGESQMNGEGRTA-YLVMELVNGEPLNSVLKRTGR----LSLRHALDMLEQTG 126 Query: 167 RSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVS--YICSRYYRA 224 R+L H+ G+ HRD+KP N+L+ P V K+ DFG AK + + + + Y A Sbjct: 127 RALQIAHAAGLVHRDVKPGNILITPTGQV-KITDFGIAKAVDAAPVTQTGMVMGTAQYIA 185 Query: 225 PELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIK 271 PE G D + + DV+S G V E + G+ F GD + ++ IK Sbjct: 186 PEQALGH-DASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIK 231 >5WNO-A nrPDB Length = 330 Score = 163 bits (413), Expect = 1e-40, Method: Composition-based stats. Identities = 69/321 (21%), Positives = 115/321 (35%), Gaps = 41/321 (12%) Query: 52 QEVSYTDTKVIGNGSFGVVYQA-----KLCDSGELVAIKKVLQDKRFKNR---ELQIMRK 103 E+ K +G G+FG V+ + + VAIK D+ + E M + Sbjct: 20 SELQTKLDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTDQSQTDEMLEEATNMFR 79 Query: 104 LDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMY 163 L H N++++ F L +V Y P + + K+ L LY Y Sbjct: 80 LRHDNLLKIIGFCMHDDG------LKIVTIYRP--LGNLQNFLKLHKENLGAREQVLYCY 131 Query: 164 QLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY-- 221 Q+ + Y+ + HRD+ +N+L+ V ++ DFG +K L +++ + Sbjct: 132 QIASGMQYLEKQRVVHRDLATRNVLVKKFNHV-EITDFGLSKILKHDADSITIKSGKVAI 190 Query: 222 -YRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTRE 279 + A E IF YT + DVW+ G E++ GQ + G S D + +K + Sbjct: 191 KWLAIE-IFSKHCYTHASDVWAFGVTCWEIITFGQSPYQGMST-DSIHNFLK-------D 241 Query: 280 QIREMNPNYTEFKFPQIKAHPWTKVFRPR-----TPPEAIALCS--RLLEYTPTA----R 328 R P Q W + R C +L Sbjct: 242 GNRLSQPPNCSQDLYQELLRCWMADPKSRPGFEILYERFKEFCKVPQLFLENSNKISESD 301 Query: 329 LTPLEACAHSFFDELRDPNVK 349 L+ E E+ D N+ Sbjct: 302 LSAEERFQTERIREMFDGNID 322 >4FL3-A nrPDB Length = 635 Score = 161 bits (408), Expect = 4e-40, Method: Composition-based stats. Identities = 66/304 (21%), Positives = 114/304 (37%), Gaps = 43/304 (14%) Query: 35 SKVTTVVATPGQGPD--RPQEVSYTDT------KVIGNGSFGVVYQAKL-----CDSGEL 81 T V +P P+ RP+EV K +G+G+FG V + + + Sbjct: 342 PMDTEVFESPFADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAV 401 Query: 82 VAIKKVLQDKRFKNR---ELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVL-DYVPE 137 +K D K+ E +M++LD+ IVR+ + + L + + + P Sbjct: 402 KILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGIC-----EAESWMLVMEMAELGPL 456 Query: 138 TVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLK 197 Y + + K + +++ Q+ + Y+ HRD+ +N+LL K Sbjct: 457 NKYLQQNRHVKDKNIIELVH------QVSMGMKYLEESNFVHRDLAARNVLLVTQ-HYAK 509 Query: 198 LCDFGSAKQLVRGEPNVS-YICSRY---YRAPELIFGATDYTSSIDVWSAGCVLAELL-L 252 + DFG +K L E ++ + APE I ++S DVWS G ++ E Sbjct: 510 ISDFGLSKALRADENYYKAQTHGKWPVKWYAPECI-NYYKFSSKSDVWSFGVLMWEAFSY 568 Query: 253 GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPE 312 GQ + G G + + K R P + + WT R Sbjct: 569 GQKPYRGMKGSEVTAMLEK--------GERMGCPAGCPREMYDLMNLCWTYDVENRPGFA 620 Query: 313 AIAL 316 A+ L Sbjct: 621 AVEL 624 >5C26-A nrPDB Length = 299 Score = 161 bits (407), Expect = 6e-40, Method: Composition-based stats. Identities = 66/301 (21%), Positives = 114/301 (37%), Gaps = 43/301 (14%) Query: 38 TTVVATPGQGPD--RPQEVSYTDT------KVIGNGSFGVVYQAKL-----CDSGELVAI 84 T V +P P+ RP+EV K +G+G+FG V + + + + Sbjct: 3 TEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKIL 62 Query: 85 KKVLQDKRFKNR---ELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVL-DYVPETVY 140 K D K+ E +M++LD+ IVR+ + + L + + + P Y Sbjct: 63 KNEANDPALKDELLAEANVMQQLDNPYIVRMIGIC-----EAESWMLVMEMAELGPLNKY 117 Query: 141 RVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCD 200 + + K + +++ Q+ + Y+ HRD+ +N+LL K+ D Sbjct: 118 LQQNRHVKDKNIIELVH------QVSMGMKYLEESNFVHRDLAARNVLLVTQ-HYAKISD 170 Query: 201 FGSAKQLVRGEPNVS-YICSRY---YRAPELIFGATDYTSSIDVWSAGCVLAELL-LGQP 255 FG +K L E ++ + APE I ++S DVWS G ++ E GQ Sbjct: 171 FGLSKALRADENYYKAQTHGKWPVKWYAPECI-NYYKFSSKSDVWSFGVLMWEAFSYGQK 229 Query: 256 IFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIA 315 + G G + + K R P + + WT R A+ Sbjct: 230 PYRGMKGSEVTAMLEK--------GERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVE 281 Query: 316 L 316 L Sbjct: 282 L 282 >3LMG-A nrPDB Length = 344 Score = 158 bits (400), Expect = 4e-39, Method: Composition-based stats. Identities = 69/290 (23%), Positives = 113/290 (38%), Gaps = 36/290 (12%) Query: 51 PQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIK---KVLQDKRFKNR------ELQIM 101 +E KV+G+G FG V++ GE + I KV++DK + + + Sbjct: 28 FKETELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAI 87 Query: 102 RKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLY 161 LDH +IVRL S L LV Y+P + + H + + L + + Sbjct: 88 GSLDHAHIVRLLGLCPGSS-------LQLVTQYLP--LGSLLDHVRQHRGALGPQLLLNW 138 Query: 162 MYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPN--VSYICS 219 Q+ + + Y+ G+ HR++ +N+LL + V ++ DFG A L + S + Sbjct: 139 GVQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQV-QVADFGVADLLPPDDKQLLYSEAKT 197 Query: 220 R-YYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPT 277 + A E I YT DVWS G + EL+ G + G +L E+ +L Sbjct: 198 PIKWMALESIH-FGKYTHQSDVWSYGVTVWELMTFGAEPYAGL----RLAEVPDLL---- 248 Query: 278 REQIREMNPNYTEFKFPQIKAHPW--TKVFRPRTPPEAIALCSRLLEYTP 325 + R P + W + RP A + P Sbjct: 249 EKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKELANEFTR--MARDP 296 >5L2Q-C nrPDB Length = 320 Score = 157 bits (398), Expect = 7e-39, Method: Composition-based stats. Identities = 60/302 (19%), Positives = 99/302 (32%), Gaps = 63/302 (20%) Query: 71 YQAKLCDSGELVAIKKV---------------LQDKRFKNRELQIMRKLD-HCNIVRLRY 114 A+ + + +K + Q K + E ++ L +V Sbjct: 33 CLARKDGTDDFYQLKILTLEERGDQGIESQEERQGKMLLHTEYSLLSLLHTQDGVVHHHG 92 Query: 115 FFYSSGE------------KKDEVYLNLVLD-YVPETVYR------VARHYSRAKQTLPV 155 F KK + + LVLD +HY ++ L Sbjct: 93 LFQDRTCEIVEDTESSRMVKKMKKRICLVLDCLCAHDFSDKTADLINLQHYVIKEKRLSE 152 Query: 156 IYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLV-RGEPNV 214 + Y + R + +H I HRD+K N++L+ T + + +F K LV G+ Sbjct: 153 RETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEGDLLK 212 Query: 215 SYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLG 274 S Y +P+++ G D+W+ G VL +L GQ F DS +L IK Sbjct: 213 DQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPFY-DSIPQELFRKIKA-- 269 Query: 275 TPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEA 334 E+ P+ R + L +LL P RL + Sbjct: 270 --------------AEYTIPE----------DGRVSENTVCLIRKLLVLDPQQRLAAADV 305 Query: 335 CA 336 Sbjct: 306 LE 307 >5XD6-A nrPDB Length = 305 Score = 156 bits (394), Expect = 2e-38, Method: Composition-based stats. Identities = 66/298 (22%), Positives = 107/298 (35%), Gaps = 26/298 (8%) Query: 38 TTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNR- 96 +V A P + +Y +IG GS+G V+ L SG+ AIKK+ K+ Sbjct: 7 ISVAAIPADELRDITD-NYGSKSLIGEGSYGRVFYGILK-SGKAAAIKKLDSSKQPDQEF 64 Query: 97 --ELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRA----- 149 ++ ++ +L N+V L + D L +Y P H + Sbjct: 65 LAQVSMVSRLRQENVVALLGYCV------DGPLRVLAYEYAPNGSLHDILHGRKGVKGAQ 118 Query: 150 -KQTLPVIYVKLYMYQLFRSLAYIHSF---GICHRDIKPQNLLLDPDTAVLKLCDFGSAK 205 L R L Y+H + HRDIK N+LL D V K+ DF + Sbjct: 119 PGPVLSWHQRVKIAVGAARGLEYLHEKANPHVIHRDIKSSNVLLFDDD-VAKIADFDLSN 177 Query: 206 Q---LVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSG 262 Q + + + + Y APE T ++ DV+S G VL ELL G+ Sbjct: 178 QAPDMAARLHSTRVLGTFGYHAPEYAMTGTL-STKSDVYSFGVVLLELLTGRKPVDHTLP 236 Query: 263 VDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRL 320 Q + + +++++ ++P V EA + Sbjct: 237 RGQQSVVTWATPKLSEDKVKQCVDARLNGEYPPKAVAKLAAVAALCVQYEA-DFRPNM 293 >5IKW-A nrPDB Length = 310 Score = 153 bits (386), Expect = 2e-37, Method: Composition-based stats. Identities = 69/304 (22%), Positives = 110/304 (36%), Gaps = 59/304 (19%) Query: 57 TDTKVIGNGSFGVVYQAKLCDSGELVAIKKV----LQDKRFKNRELQIMRKLD-HCNIVR 111 T + + G F V+ + G A+K++ + D RE+ IM++L H NIV Sbjct: 17 TLEESLAEGGFSTVFLVR-THGGIRCALKRMYVNNMPDLNVCKREITIMKELSGHKNIVG 75 Query: 112 LRYFFYSSGEKKDEVYLNLV-LDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLA 170 + D V+ L+ ++Y V + + + V ++A Sbjct: 76 YLDC--AVNSISDNVWEVLILMEYCRAGQV-VNQMNKKLQTGFTEPEVLQIFCDTCEAVA 132 Query: 171 YIHSFG--ICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRG---------EPNVSYICS 219 +H I HRD+K +N+LL+ D LCDFGSA E + + Sbjct: 133 RLHQCKTPIIHRDLKVENILLN-DGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTT 191 Query: 220 RYYRAPELI--FGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPT 277 YRAPE+I +G T+ D+W+ GC+L +L F G+S Sbjct: 192 LSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPF-GES---------------- 234 Query: 278 REQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAH 337 ++ F P R L +LE P R + Sbjct: 235 -----QVAICDGNFTIPD----------NSRYSRNIHCLIRFMLEPDPEHRPDIFQV--- 276 Query: 338 SFFD 341 S+F Sbjct: 277 SYFA 280 >3HNG-A nrPDB Length = 360 Score = 152 bits (385), Expect = 2e-37, Method: Composition-based stats. Identities = 50/187 (26%), Positives = 85/187 (45%), Gaps = 15/187 (8%) Query: 138 TVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLK 197 V K+ + + + Y +Q+ R + ++ S HRD+ +N+LL + V+K Sbjct: 181 DVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENN-VVK 239 Query: 198 LCDFGSAKQLVRGEPNVSYICSRY---YRAPELIFGATDYTSSIDVWSAGCVLAELLL-G 253 +CDFG A+ + + V +R + APE IF Y++ DVWS G +L E+ G Sbjct: 240 ICDFGLARDIYKNPDYVRKGDTRLPLKWMAPESIFDKI-YSTKSDVWSYGVLLWEIFSLG 298 Query: 254 QPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEA 313 +PG V++ + + RE +R P Y+ + QI W + P+ P Sbjct: 299 GSPYPG-------VQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHR--DPKERPRF 349 Query: 314 IALCSRL 320 L +L Sbjct: 350 AELVEKL 356 Score = 57.7 bits (138), Expect = 9e-09, Method: Composition-based stats. Identities = 24/116 (20%), Positives = 40/116 (34%), Gaps = 16/116 (13%) Query: 57 TDTKVIGNGSFGVVYQA-----KLCDSGELVAIKKVLQ-----DKRFKNRELQIMRKLDH 106 K +G G+FG V QA K + VA+K + + + + EL+I+ + H Sbjct: 30 KLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASEYKALMTELKILTHIGH 89 Query: 107 C-NIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLY 161 N+V L G L ++++Y R L Sbjct: 90 HLNVVNLLGACTKQG-----GPLMVIVEYCKYGNLSNYLKSKRDLFFLNKDAALHM 140 >2QKW-B nrPDB Length = 321 Score = 152 bits (383), Expect = 3e-37, Method: Composition-based stats. Identities = 64/289 (22%), Positives = 108/289 (37%), Gaps = 29/289 (10%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKK----VLQDKRFKNRELQIMRKLDHCNIV 110 ++ +IG+G FG VY+ L D G VA+K+ Q E++ + H ++V Sbjct: 40 NFDHKFLIGHGVFGKVYKGVLRD-GAKVALKRRTPESSQGIEEFETEIETLSFCRHPHLV 98 Query: 111 RLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQ-TLPVIYVKLYMYQLFRSL 169 L F E + L+ Y+ + + S ++ R L Sbjct: 99 SLIGFCDERNE------MILIYKYMENGNLKRHLYGSDLPTMSMSWEQRLEICIGAARGL 152 Query: 170 AYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ---LVRGEPNVSYICSRYYRAPE 226 Y+H+ I HRD+K N+LLD + V K+ DFG +K+ L + + + Y PE Sbjct: 153 HYLHTRAIIHRDVKSINILLDENF-VPKITDFGISKKGTELDQTHLSTVVKGTLGYIDPE 211 Query: 227 LIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNP 286 F T DV+S G VL E+L + I++ L Sbjct: 212 -YFIKGRLTEKSDVYSFGVVLFEVLCARS------------AIVQSLPREMVNLAEWAVE 258 Query: 287 NYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEAC 335 ++ + QI RP + + + L + R + + Sbjct: 259 SHNNGQLEQIVDPNLADKIRPESLRKFGDTAVKCLALSSEDRPSMGDVL 307 >3SOC-A nrPDB Length = 322 Score = 152 bits (383), Expect = 3e-37, Method: Composition-based stats. Identities = 66/301 (21%), Positives = 115/301 (38%), Gaps = 35/301 (11%) Query: 51 PQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKV-LQDKRFKNRELQI--MRKLDHC 107 Q + +V G FG V++A+L E VA+K +QDK+ E ++ + + H Sbjct: 21 FQSMPLQLLEVKARGRFGCVWKAQLL--NEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHE 78 Query: 108 NIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFR 167 NI++ +V L L+ + + + + + R Sbjct: 79 NILQFIGA--EKRGTSVDVDLWLITAFHEKGSLSDFLK----ANVVSWNELCHIAETMAR 132 Query: 168 SLAYIHSF----------GICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEP---NV 214 LAY+H I HRDIK +N+LL + + DFG A + G+ Sbjct: 133 GLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTAC-IADFGLALKFEAGKSAGDTH 191 Query: 215 SYICSRYYRAPELIFGATDYTS----SIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEII 270 + +R Y APE++ GA ++ ID+++ G VL EL G L Sbjct: 192 GQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEE 251 Query: 271 KVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLT 330 ++ P+ E ++E+ + + + W K E ++ ARL+ Sbjct: 252 EIGQHPSLEDMQEVVVHKKK---RPVLRDYWQKHAGMAMLCET---IEECWDHDAEARLS 305 Query: 331 P 331 Sbjct: 306 A 306 >3ZZW-A nrPDB Length = 289 Score = 151 bits (382), Expect = 5e-37, Method: Composition-based stats. Identities = 59/286 (20%), Positives = 100/286 (34%), Gaps = 35/286 (12%) Query: 57 TDTKVIGNGSFGVVYQAKLC-----DSGELVAIKKVLQDKRFKNRE-----LQIMRKLDH 106 + +G FG VY+ L + + VAIK + RE + +L H Sbjct: 12 RFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRARLQH 71 Query: 107 CNIVRLRYFFYS--------SGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYV 158 N+V L S +++ LV+ P + K L Sbjct: 72 PNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRS-PHSDVGSTDDDRTVKSALEPPDF 130 Query: 159 KLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYIC 218 + Q+ + Y+ S + H+D+ +N+L+ D +K+ D G +++ + Sbjct: 131 VHLVAQIAAGMEYLSSHHVVHKDLATRNVLV-YDKLNVKISDLGLFREVYAADYYKLLGN 189 Query: 219 SR---YYRAPELIFGATDYTSSIDVWSAGCVLAELL-LGQPIFPGDSGVDQLVEIIKVLG 274 S + APE I ++ D+WS G VL E+ G + G S D + I Sbjct: 190 SLLPIRWMAPEAIM-YGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQV 248 Query: 275 TPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRL 320 P P+ + W + P P + SRL Sbjct: 249 LPC--------PDDCPAWVYALMIECWNEF--PSRRPRFKDIHSRL 284 >3G2F-A nrPDB Length = 336 Score = 151 bits (381), Expect = 6e-37, Method: Composition-based stats. Identities = 68/309 (22%), Positives = 123/309 (39%), Gaps = 44/309 (14%) Query: 54 VSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKV-LQDKRFKNRELQIMR--KLDHCNIV 110 + ++IG G +G VY+ L + VA+K +++ E I R ++H NI Sbjct: 13 DNLKLLELIGRGRYGAVYKGSLDE--RPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIA 70 Query: 111 RLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLA 170 R YL LV++Y P + ++ S T + + + R LA Sbjct: 71 RFIVGDERVTADGRMEYL-LVMEYYPNG--SLCKYLSLH--TSDWVSSCRLAHSVTRGLA 125 Query: 171 YIHSF---------GICHRDIKPQNLLLDPDTAVLKLCDFGSAKQL---------VRGEP 212 Y+H+ I HRD+ +N+L+ D + + DFG + +L Sbjct: 126 YLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCV-ISDFGLSMRLTGNRLVRPGEEDNA 184 Query: 213 NVSYICSRYYRAPELIFGATDYT------SSIDVWSAGCVLAELLLGQP-IFPGDSGVD- 264 +S + + Y APE++ GA + +D+++ G + E+ + +FPG+S + Sbjct: 185 AISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVPEY 244 Query: 265 QLVEIIKVLGTPTREQIREM-NPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEY 323 Q+ +V PT E ++ + + KFP+ W + + Sbjct: 245 QMAFQTEVGNHPTFEDMQVLVSREKQRPKFPE----AWKENSLAVRSL--KETIEDCWDQ 298 Query: 324 TPTARLTPL 332 ARLT Sbjct: 299 DAEARLTAQ 307 >5WNL-A nrPDB Length = 342 Score = 149 bits (377), Expect = 2e-36, Method: Composition-based stats. Identities = 68/353 (19%), Positives = 120/353 (33%), Gaps = 60/353 (16%) Query: 60 KVIGNGSFGVVYQAKLCDSGELVAIK------KVLQDKRFKNRELQIMRKLDHCNIVRLR 113 + +G+G FG VY+ + +AIK +++ E + M I+ + Sbjct: 26 EKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERMELLEEAKKMEMAKFRYILPVY 85 Query: 114 YFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIH 173 + LV++Y+ A + LP +++ + ++H Sbjct: 86 GICQEP--------VGLVMEYMETGSLEKLL----ASEPLPWDLRFRIVHETAVGMNFLH 133 Query: 174 SFG--ICHRDIKPQNLLLDPDTAVLKLCDFGSAK----QLVRGEPNVSYICSRYYRAPEL 227 + H ++KP N+LLD V K+ DFG AK + Y PE Sbjct: 134 CMSPPLLHLNLKPANILLDAHYHV-KISDFGLAKCNGMSHSHDLSMDGLFGTIAYLPPER 192 Query: 228 IFGATD-YTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNP 286 I + + + DV+S V+ +L + F + L ++KV+ E P Sbjct: 193 IREKSRLFDTKHDVYSFAIVIWGVLTQKKPF--ADEKNILHIMMKVVKGHRPELPPICRP 250 Query: 287 NYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDP 346 RPR I L R P R T F E+ Sbjct: 251 -------------------RPRACASLIGLMQRCWHADPQVRPT---------FQEITSE 282 Query: 347 NVKLPNGRDTP--ALFNFTTQELSSNPPLATILIPPHARIQAAASPPANATAA 397 L D L + ++ S + P +R++ A++PP + + Sbjct: 283 TEDLCEKPDEEVKDLAHEPGEKSSLES--KSEARPESSRLKRASAPPFDNDCS 333 >3MDY-A nrPDB Length = 337 Score = 149 bits (376), Expect = 2e-36, Method: Composition-based stats. Identities = 65/301 (21%), Positives = 109/301 (36%), Gaps = 47/301 (15%) Query: 57 TDTKVIGNGSFGVVYQAKLCDSGELVAIKKVL-QDKRFKNRELQIMRKL--DHCNIVRLR 113 K IG G +G V+ K GE VA+K ++ RE +I + + H NI+ Sbjct: 40 QMVKQIGKGRYGEVWMGKWR--GEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFI 97 Query: 114 YFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIH 173 ++Y L+ DY + TL + Y L ++H Sbjct: 98 AADIKGTGSWTQLY--LITDYHENGSL----YDYLKSTTLDAKSMLKLAYSSVSGLCHLH 151 Query: 174 SF--------GICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNV-----SYICSR 220 + I HRD+K +N+L+ + + D G A + + V + + ++ Sbjct: 152 TEIFSTQGKPAIAHRDLKSKNILVKKNGTCC-IADLGLAVKFISDTNEVDIPPNTRVGTK 210 Query: 221 YYRAPELI---FGATDYTSS--IDVWSAGCVLAE----LLLGQPIFPGDSGVDQLVEIIK 271 Y PE++ + S D++S G +L E + G G QL Sbjct: 211 RYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSG-----GIVEEYQLPYHDL 265 Query: 272 VLGTPTREQIREM-NPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLT 330 V P+ E +RE+ FP W+ R + L + + P +RLT Sbjct: 266 VPSDPSYEDMREIVCIKKLRPSFPNR----WSSDECLRQMGK---LMTECWAHNPASRLT 318 Query: 331 P 331 Sbjct: 319 A 319 >3Q4U-A nrPDB Length = 301 Score = 149 bits (375), Expect = 3e-36, Method: Composition-based stats. Identities = 57/306 (18%), Positives = 107/306 (34%), Gaps = 57/306 (18%) Query: 57 TDTKVIGNGSFGVVYQAKLCDSGELVAIKKVL-QDKRFKNRELQIMR--KLDHCNIVRLR 113 T + +G G +G V++ GE VA+K +D++ RE ++ L H NI+ Sbjct: 11 TLLECVGKGRYGEVWRGSWQ--GENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFI 68 Query: 114 YFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIH 173 +S + L L+ Y + TL + + + LA++H Sbjct: 69 ASDMTSRHSSTQ--LWLITHYHEMGSLYDYLQLT----TLDTVSCLRIVLSIASGLAHLH 122 Query: 174 --------SFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVS-----YICSR 220 I HRD+K +N+L+ + + D G A + + + ++ Sbjct: 123 IEIFGTQGKPAIAHRDLKSKNILVKKNGQCC-IADLGLAVMHSQSTNQLDVGNNPRVGTK 181 Query: 221 YYRAPELIFGATDYT-----SSIDVWSAGCVLAELLLG----------QPIFPGDSGVDQ 265 Y APE++ +D+W+ G VL E+ +P F D Sbjct: 182 RYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDP 241 Query: 266 LVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTP 325 E ++ + +++ N +++ + L P Sbjct: 242 SFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAK-----------------LMKECWYQNP 284 Query: 326 TARLTP 331 +ARLT Sbjct: 285 SARLTA 290 >3VHK-A nrPDB Length = 368 Score = 148 bits (373), Expect = 4e-36, Method: Composition-based stats. Identities = 51/192 (26%), Positives = 80/192 (41%), Gaps = 33/192 (17%) Query: 150 KQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVR 209 K L + ++ Y +Q+ + + ++ S HRD+ +N+LL + V+K+CDFG A+ + + Sbjct: 194 KDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILL-SEKNVVKICDFGLARDIYK 252 Query: 210 GEPNVSYICSRY---YRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQ 265 V +R + APE IF YT DVWS G +L E+ G +PG Sbjct: 253 DPDYVRKGDARLPLKWMAPETIFDRV-YTIQSDVWSFGVLLWEIFSLGASPYPG------ 305 Query: 266 LVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTP 325 V+I + +E R P+YT + Q W P Sbjct: 306 -VKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHG--------------------EP 344 Query: 326 TARLTPLEACAH 337 + R T E H Sbjct: 345 SQRPTFSELVEH 356 Score = 55.8 bits (133), Expect = 3e-08, Method: Composition-based stats. Identities = 21/105 (20%), Positives = 39/105 (37%), Gaps = 16/105 (15%) Query: 57 TDTKVIGNGSFGVVYQA----KLC-DSGELVAIKKVLQ-----DKRFKNRELQIMRKLDH 106 K +G G+FG V +A + VA+K + + + R EL+I+ + H Sbjct: 32 KLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGH 91 Query: 107 C-NIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAK 150 N+V L G L +++++ R + Sbjct: 92 HLNVVNLLGACTKPG-----GPLMVIVEFCKFGNLSTYLRSKRNE 131 >4M66-A nrPDB Length = 325 Score = 148 bits (373), Expect = 5e-36, Method: Composition-based stats. Identities = 63/294 (21%), Positives = 109/294 (37%), Gaps = 34/294 (11%) Query: 37 VTTVVATPGQGPDRP--QEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFK 94 +++V P P + +G G FGVV++A VA+K V K Sbjct: 1 MSSVKLWPTGASAVPLVSREELKKLEFVGKGGFGVVFRAHHRTWNHDVAVKIVNSKKISW 60 Query: 95 NRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLN---LVLDYVPETVYRVARHYSRAKQ 151 E++ M L + N++ L E +++ LV ++ + + Sbjct: 61 --EVKAMVNLRNENVLLLLGV----TEDLQWDFVSGQALVTRFMENGSLAGLL---QPEA 111 Query: 152 TLPVIYVKLYMYQLFRSLAYIHSFG--ICHRDIKPQNLLLDPDTAVLKLCDFGSAK---- 205 P + + ++ + Y+HS + HRD+KP N+LLDP+ KL DFG + Sbjct: 112 PRPWPLLCRLLQEVVLGMCYLHSLDPPLLHRDLKPSNILLDPELHA-KLADFGLSTFQGG 170 Query: 206 ---QLVRGEPNVSYICSRYYRAPELIFGAT-DYTSSIDVWSAGCVLAELLLGQPIFPGDS 261 G + + Y PEL+F + + DV+S G ++ +L G+ Sbjct: 171 SQSGSGSGSGSRDSGGTLAYLDPELLFKVNLKASKASDVYSFGILVWAVLAGRE----AE 226 Query: 262 GVDQLVEIIKVLG-----TPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTP 310 VD+ I + + P E K ++ H W R Sbjct: 227 LVDKTSLIRETVCDRQSRPPLTELPPGSPETPGLEKLKELMIHCWGSQSENRPS 280 >4JRN-A nrPDB Length = 372 Score = 148 bits (373), Expect = 6e-36, Method: Composition-based stats. Identities = 78/356 (21%), Positives = 119/356 (33%), Gaps = 79/356 (22%) Query: 28 VSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVI------GNGSFGVVYQAKLCDSGEL 81 + + ++ TV A P P R V+ +T+ + G+G F VY+A ++ E Sbjct: 36 LENSERLDRILTVAAWPPDVPKRFVSVTTGETRTLVRGAPLGSGGFATVYEATDVETNEE 95 Query: 82 VAIKKVLQDKR-------FKNRELQIMRKL-----------DHCNIVRLRYFFYSSGEKK 123 +A+K + +K RE R +V Sbjct: 96 LAVKVFMSEKEPTDETMLDLQRESSCYRNFSLAKTAKDAQESCRFMVPSDVVMLEGQPAS 155 Query: 124 DEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIY-------------VKLYM-YQLFRSL 169 EV + L +VP + R + + + ++ V++Y+ Q + + Sbjct: 156 TEVVIGLTTRWVPNYFLLMMRAEADMSKVISWVFGDASVNKSEFGLVVRMYLSSQAIKLV 215 Query: 170 AYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIF 229 A + + GI H DIKP N LL D L L DFG+ + I + Y PE F Sbjct: 216 ANVQAQGIVHTDIKPANFLLLKD-GRLFLGDFGTYRI---NNSVGRAIGTPGYEPPERPF 271 Query: 230 GATD--YTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPN 287 AT YT D W G L + + P D D L Sbjct: 272 QATGITYTFPTDAWQLGITLYCIWCKERPTPADGIWDYLHF------------------- 312 Query: 288 YTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDEL 343 P TP L LL P R+ PL+A + F E+ Sbjct: 313 ----------------ADCPSTPELVQDLIRSLLNRDPQKRMLPLQALETAAFKEM 352 >5AR8-A nrPDB Length = 326 Score = 147 bits (370), Expect = 1e-35, Method: Composition-based stats. Identities = 58/299 (19%), Positives = 110/299 (36%), Gaps = 35/299 (11%) Query: 58 DTKVIGNGSFGVVYQAKLCDSGELVAIKKV-------LQDKRFKNRELQIMRKLDHCNIV 110 D + + G+ G V A+ D VA+K + +++ RE +I+ K I+ Sbjct: 36 DLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYIL 95 Query: 111 RLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLA 170 + + +L +V +Y+P H + ++++ + Sbjct: 96 PILGIC------NEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVN 149 Query: 171 YIHSFG--ICHRDIKPQNLLLDPDTAVLKLCDFGSAK------QLVRGEPNVSYICSRYY 222 Y+H+ + H D+K QN+LLD + V K+ DFG +K R + + Y Sbjct: 150 YLHNMTPPLLHHDLKTQNILLDNEFHV-KIADFGLSKWRMMSLSQSRSSKSAPEGGTIIY 208 Query: 223 RAPELIF--GATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQ 280 PE + + D++S + E+L + F + Q++ + P Sbjct: 209 MPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPV--- 265 Query: 281 IREMNPNYTEFKFPQIKAH-PWTKVFRPRTPPEAIALCSRLLEYTPTAR----LTPLEA 334 +N + P + + P E + L+E P R +T LEA Sbjct: 266 ---INEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEA 321 >5E8V-A nrPDB Length = 316 Score = 147 bits (370), Expect = 1e-35, Method: Composition-based stats. Identities = 67/313 (21%), Positives = 107/313 (34%), Gaps = 62/313 (19%) Query: 57 TDTKVIGNGSFGVVYQAKLCDSG----ELVAIKKVL-QDKRFKNRELQIMRK--LDHCNI 109 ++G G F VY+AKL + E VA+K ++ E I L H NI Sbjct: 12 ELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENI 71 Query: 110 VRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 169 ++ E + +L + RH + ++ L R + Sbjct: 72 LQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRH------VISWEDLRKLGSSLARGI 125 Query: 170 AYIHS---------FGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQL-----VRGEPNVS 215 A++HS I HRD+K N+L+ D LCDFG + +L V N Sbjct: 126 AHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCC-LCDFGLSLRLDPTLSVDDLANSG 184 Query: 216 YICSRYYRAPELIFGATDYT-----SSIDVWSAGCVLAELLLG----------QPIFPGD 260 + + Y APE++ A + DV+S VL E+ +P F Sbjct: 185 QVGTARYMAPEVLASAMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGS- 243 Query: 261 SGVDQLVEIIKVLGTPTREQIRE-MNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSR 319 KV P + + + + + P W + E + Sbjct: 244 ----------KVREHPCVASMADNVLADAGRPEIPSF----WLNHQGIQMVCET---LTE 286 Query: 320 LLEYTPTARLTPL 332 ++ P ARLT Sbjct: 287 CWDHDPEARLTAQ 299 >2QLU-A nrPDB Length = 314 Score = 146 bits (369), Expect = 1e-35, Method: Composition-based stats. Identities = 73/299 (24%), Positives = 121/299 (40%), Gaps = 42/299 (14%) Query: 57 TDTKVIGNGSFGVVYQAKLCDSGELVAIKKV-LQDKRFKNRELQIMRK--LDHCNIVRLR 113 ++ G FG V++A+L + VA+K LQDK+ E +I + H N+++ Sbjct: 18 QLLEIKARGRFGCVWKAQLMND--FVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQFI 75 Query: 114 YFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIH 173 EV L L+ + + Y + + + + R L+Y+H Sbjct: 76 AA--EKRGSNLEVELWLITAFHDKGS---LTDYLKG-NIITWNELCHVAETMSRGLSYLH 129 Query: 174 SF-----------GICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEP---NVSYICS 219 I HRD K +N+LL D + L DFG A + G+P + + Sbjct: 130 EDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAV-LADFGLAVRFEPGKPPGDTHGQVGT 188 Query: 220 RYYRAPELIFGATDYTS----SIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGT 275 R Y APE++ GA ++ ID+++ G VL EL+ G L ++ Sbjct: 189 RRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQH 248 Query: 276 PTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALC---SRLLEYTPTARLTP 331 P+ E+++E+ + P IK H W K P LC ++ ARL+ Sbjct: 249 PSLEELQEVVVHKKMR--PTIKDH-WLK------HPGLAQLCVTIEECWDHDAEARLSA 298 >2H34-A nrPDB Length = 309 Score = 145 bits (367), Expect = 2e-35, Method: Composition-based stats. Identities = 57/231 (24%), Positives = 100/231 (43%), Gaps = 20/231 (8%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQD-------KRFKNRELQIMRKLDHCN 108 Y +++G G G VY+A+ +VA+K + + + RE + +L + Sbjct: 36 YRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRTRMQREARTAGRLQEPH 95 Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRS 168 +V + F GE ++Y+++ L + + R + L + Q+ + Sbjct: 96 VVPIHDF----GEIDGQLYVDMRLINGVDLAAML-----RRQGPLAPPRAVAIVRQIGSA 146 Query: 169 LAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNV--SYICSRYYRAPE 226 L H+ G HRD+KP+N+L+ D L DFG A + + + + YY APE Sbjct: 147 LDAAHAAGATHRDVKPENILVSADDFAY-LVDFGIASATTDEKLTQLGNTVGTLYYMAPE 205 Query: 227 LIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPT 277 F + T D+++ CVL E L G P + GD I + + P+ Sbjct: 206 R-FSESHATYRADIYALTCVLYECLTGSPPYQGDQLSVMGAHINQAIPRPS 255 >1PY5-A nrPDB Length = 326 Score = 145 bits (367), Expect = 3e-35, Method: Composition-based stats. Identities = 65/296 (21%), Positives = 110/296 (37%), Gaps = 39/296 (13%) Query: 58 DTKVIGNGSFGVVYQAKLCDSGELVAIKKV-LQDKRFKNRELQIMR--KLDHCNIVRLRY 114 + IG G FG V++ K GE VA+K +++R RE +I + L H NI+ Sbjct: 33 LQESIGKGRFGEVWRGKWR--GEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIA 90 Query: 115 FFYSSGEKKDEVYLNLVLDYVPET-VYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIH 173 + + L LV DY ++ Y T+ V + LA++H Sbjct: 91 A--DNKDNGTWTQLWLVSDYHEHGSLFDYLNRY-----TVTVEGMIKLALSTASGLAHLH 143 Query: 174 --------SFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVS-----YICSR 220 I HRD+K +N+L+ + + D G A + + + ++ Sbjct: 144 MEIVGTQGKPAIAHRDLKSKNILVKKNGTCC-IADLGLAVRHDSATDTIDIAPNHRVGTK 202 Query: 221 YYRAPELIFGATDYT-----SSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGT 275 Y APE++ + + D+++ G V E+ I G QL V Sbjct: 203 RYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSI-GGIHEDYQLPYYDLVPSD 261 Query: 276 PTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTP 331 P+ E++R++ E K + W R + + ARLT Sbjct: 262 PSVEEMRKV---VCEQKLRPNIPNRWQSCEALRVMAK---IMRECWYANGAARLTA 311 >4LQP-A nrPDB Length = 508 Score = 144 bits (363), Expect = 7e-35, Method: Composition-based stats. Identities = 46/169 (27%), Positives = 77/169 (45%), Gaps = 17/169 (10%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNR-------ELQIMRKLDHC 107 + KVIG G+FG V + D+G++ A+K +L+ + +K E ++ D Sbjct: 103 DFHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKDQLAHVKAERDVLAGSDSP 162 Query: 108 NIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFR 167 +V L Y F +D YL L+++++P + R Q + YM + Sbjct: 163 WVVSLYYSF------QDAQYLYLIMEFLPGG--DLMTMLIRW-QLFTEDVTRFYMAECIL 213 Query: 168 SLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSY 216 ++ IH G HR IKP N+L+D +KL DFG + + + Y Sbjct: 214 AIETIHKLGFIHRAIKPDNILIDIRGH-IKLSDFGLSTGFHKTHDSNYY 261 Score = 98.9 bits (245), Expect = 3e-21, Method: Composition-based stats. Identities = 40/180 (22%), Positives = 58/180 (32%), Gaps = 37/180 (20%) Query: 214 VSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVL 273 S + + Y APE IF Y D WS G ++ E L+G P F ++ + +I+ Sbjct: 321 YSTVGTPDYIAPE-IFLYQGYGQECDWWSLGAIMYECLIGWPPFCSETPQETYRKIMNFE 379 Query: 274 GTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARL---- 329 T +FP EA L RLL + RL Sbjct: 380 QT---------------LQFPD----------DIHISYEAEDLIRRLLTH-ADQRLGRHG 413 Query: 330 TPLEACAHSFFDEL------RDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHAR 383 E +H FF + + +P F T EL + P + R Sbjct: 414 GADEIKSHPFFRGVDWNTIRQVEAPYIPKLSSITDTRFFPTDELENVPDSPAMAQAAKQR 473 >2Y4I-B nrPDB Length = 319 Score = 142 bits (359), Expect = 2e-34, Method: Composition-based stats. Identities = 62/303 (20%), Positives = 107/303 (35%), Gaps = 49/303 (16%) Query: 57 TDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDK------RFKNRELQIMRKLDHCNIV 110 ++IG G FG VY + VAI+ + ++ + RE+ R+ H N+V Sbjct: 36 EIGELIGKGRFGQVYHGRWHG---EVAIRLIDIERDNEDQLKAFKREVMAYRQTRHENVV 92 Query: 111 RLRYFFYSSGEKKDEVYLNLVLDYVPE-TVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 169 +L ++ T+Y V R AK L V + ++ + + Sbjct: 93 LFMGAC------MSPPHLAIITSLCKGRTLYSVVRD---AKIVLDVNKTRQIAQEIVKGM 143 Query: 170 AYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGS---AKQLVRGEPNVSYICSRYY---R 223 Y+H+ GI H+D+K +N+ D + + DFG + L G + Sbjct: 144 GYLHAKGILHKDLKSKNVFY--DNGKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCHL 201 Query: 224 APELIFG--------ATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGT 275 APE+I ++ DV++ G + EL + F II +GT Sbjct: 202 APEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAE----AIIWQMGT 257 Query: 276 PTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEAC 335 + + ++ + I W F P L +LE P Sbjct: 258 GMKPNLSQIG---MGKEISDILLFCWA--FEQEERPTFTKLMD-MLEKLPKR----NRRL 307 Query: 336 AHS 338 +H Sbjct: 308 SHP 310 >5J0A-A nrPDB Length = 300 Score = 141 bits (356), Expect = 5e-34, Method: Composition-based stats. Identities = 61/304 (20%), Positives = 107/304 (35%), Gaps = 43/304 (14%) Query: 58 DTKVIGNGSFGV---VYQAKLCDSG---ELVAIKKVL---QD------KRFKNRELQIMR 102 + +G FG VY K G A+KK+ D ++ E +I++ Sbjct: 13 FMQKLG---FGTGVNVYLMKRSPRGLSHSPWAVKKINPICNDHYRSVYQKRLMDEAKILK 69 Query: 103 KLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYR--VARHYSRAKQTLPVIYVKL 160 L H NIV R F + ++ L L ++Y E + Y ++ P + Sbjct: 70 SLHHPNIVGYRAF-----TEANDGSLCLAMEYGGEKSLNDLIEERYKASQDPFPAAIILK 124 Query: 161 YMYQLFRSLAYIHS-FGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRG----EPNVS 215 + R L Y+H + H DIK N+++ D +K+CD G + L +P Sbjct: 125 VALNMARGLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMEVTDPEAC 184 Query: 216 YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGT 275 YI + ++ E + T D+++ G L E++ + + + K Sbjct: 185 YIGTEPWKPKEAVEENGVITDKADIFAFGLTLWEMMTLSIP--HINLSNDDDDEDKTFDE 242 Query: 276 PTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPL--- 332 + T P I + ++ + I L S P R + Sbjct: 243 SDFDDEAYYAALGTR---PPINMEELDESYQ-----KVIELFSVCTNEDPKDRPSAAHIV 294 Query: 333 EACA 336 EA Sbjct: 295 EALE 298 >6BFN-A nrPDB Length = 342 Score = 140 bits (353), Expect = 1e-33, Method: Composition-based stats. Identities = 53/221 (23%), Positives = 93/221 (42%), Gaps = 31/221 (14%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQD--------KRFKNRELQIMRKLDH 106 ++++ IG G FG VY+A + ++ + A+K++ ++ K+ E++ + + H Sbjct: 23 NFSEELKIGEGGFGCVYRAVMRNT--VYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRH 80 Query: 107 CNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHY-SRAKQTLPVIYVKLYMYQL 165 NIV + +G + LV ++P H ++A L + Sbjct: 81 PNIVDFAGYCAQNG------FYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGT 134 Query: 166 FRSLAYIH--SFGICHRDIKPQNLLLDPDTAVLKLCDFGSAK--QLVRGEPNVSYI---- 217 R++ ++H S + H DIK N+LLD KL DFG A+ + P+ S + Sbjct: 135 ARAIQFLHQDSPSLIHGDIKSSNVLLDERLT-PKLGDFGLARFSRFAGSSPSQSSMVART 193 Query: 218 ----CSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQ 254 + Y PE D +S G V+ E L GQ Sbjct: 194 QTVRGTLAYL-PEEYIKTGRLAVDTDTFSFGVVVLETLAGQ 233 >3MY0-A nrPDB Length = 305 Score = 139 bits (351), Expect = 2e-33, Method: Composition-based stats. Identities = 59/305 (19%), Positives = 98/305 (32%), Gaps = 57/305 (18%) Query: 58 DTKVIGNGSFGVVYQAKLCDSGELVAIKKVL-QDKRFKNRELQIMRK--LDHCNIVRLRY 114 + +G G +G V++ GE VA+K +D++ RE +I L H NI L + Sbjct: 12 LVECVGKGRYGEVWRGLWH--GESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNI--LGF 67 Query: 115 FFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIH- 173 + L L+ Y +QTL LA++H Sbjct: 68 IASDMTSRNSSTQLWLITHYHEHGSLYDFLQ----RQTLEPHLALRLAVSAACGLAHLHV 123 Query: 174 -------SFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVS-----YICSRY 221 I HRD K +N+L+ + + D G A +G + + ++ Sbjct: 124 EIFGTQGKPAIAHRDFKSRNVLVKSNLQCC-IADLGLAVMHSQGSDYLDIGNNPRVGTKR 182 Query: 222 YRAPELIFGATDYT-----SSIDVWSAGCVLAELLLG----------QPIFPGDSGVDQL 266 Y APE++ D+W+ G VL E+ +P F D Sbjct: 183 YMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPS 242 Query: 267 VEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPT 326 E +K + ++ N + + P+ Sbjct: 243 FEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQM-----------------MRECWYPNPS 285 Query: 327 ARLTP 331 ARLT Sbjct: 286 ARLTA 290 >5VC6-A nrPDB Length = 289 Score = 137 bits (344), Expect = 1e-32, Method: Composition-based stats. Identities = 54/311 (17%), Positives = 102/311 (32%), Gaps = 66/311 (21%) Query: 54 VSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ------DKRFKNRELQIMRKL-DH 106 + + + IG+G FG V++ G + AIK+ + D++ RE+ L H Sbjct: 11 TEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQH 70 Query: 107 CNIVRLRYFFYSSGEKKDEVYLNLVLDYV-PETVYRVARHYSRAKQTLPVIYVKLYMYQL 165 ++VR + ++ ++ + +Y ++ R +K + Q+ Sbjct: 71 SHVVRYFSAW------AEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQV 124 Query: 166 FRSLAYIHSFGICHRDIKPQNLLLD------------------PDTAVLKLCDFGSAKQL 207 R L YIHS + H DIKP N+ + + + K+ D G + Sbjct: 125 GRGLRYIHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLG---HV 181 Query: 208 VRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLV 267 R + A E++ + D+++ + G P DQ Sbjct: 182 TRISSPQVEEGDSRFLANEVLQENYTHLPKADIFALALTV-VCAAGAEPLP--RNGDQWH 238 Query: 268 EIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTA 327 EI + + P+I E L ++ P Sbjct: 239 EI-------------------RQGRLPRIPQ---------VLSQEFTELLKVMIHPDPER 270 Query: 328 RLTPLEACAHS 338 R + + HS Sbjct: 271 RPSAMALVKHS 281 >4BTK-A nrPDB Length = 337 Score = 135 bits (339), Expect = 5e-32, Method: Composition-based stats. Identities = 53/231 (22%), Positives = 90/231 (38%), Gaps = 20/231 (8%) Query: 53 EVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKK--VLQDKRFKNRELQIMRKLDHCNIV 110 + + K IG G FG +Y+A + E VA+K Q K+ E+ +++KL + Sbjct: 55 KDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKD-- 112 Query: 111 RLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLA 170 + G ++E + +V+ + + R R T + Q+ S+ Sbjct: 113 ---HVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRG--TFTLSTTLRLGKQILESIE 167 Query: 171 YIHSFGICHRDIKPQNLLLDPDTAVLKLC---DFGSAKQLVRGE-------PNVSYICSR 220 IHS G HRDIKP N + + + C DFG A+Q + + Sbjct: 168 AIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTV 227 Query: 221 YYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIK 271 Y A + D+WS +L E +GQ + +Q+ I + Sbjct: 228 RY-ASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKE 277 >4NFN-A nrPDB Length = 309 Score = 134 bits (338), Expect = 6e-32, Method: Composition-based stats. Identities = 53/231 (22%), Positives = 90/231 (38%), Gaps = 20/231 (8%) Query: 53 EVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKK--VLQDKRFKNRELQIMRKLDHCNIV 110 + + K IG G FG +Y+A + E VA+K Q K+ E+ +++KL + Sbjct: 20 KDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKD-- 77 Query: 111 RLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLA 170 + G ++E + +V+ + + R R T + Q+ S+ Sbjct: 78 ---HVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRG--TFTLSTTLRLGKQILESIE 132 Query: 171 YIHSFGICHRDIKPQNLLLDPDTAVLKLC---DFGSAKQLVRGE-------PNVSYICSR 220 IHS G HRDIKP N + + + C DFG A+Q + + Sbjct: 133 AIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTV 192 Query: 221 YYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIK 271 Y A + D+WS +L E +GQ + +Q+ I + Sbjct: 193 RY-ASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKE 242 >4RT7-A nrPDB Length = 415 Score = 133 bits (335), Expect = 1e-31, Method: Composition-based stats. Identities = 54/229 (23%), Positives = 87/229 (37%), Gaps = 30/229 (13%) Query: 96 RELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPV 155 RE+QI H SG + + ++Y E R+ L Sbjct: 198 REVQI-----HP------DSDQISGLHGNSFHSEDEIEY--ENQKRLEEE--EDLNVLTF 242 Query: 156 IYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVS 215 + + YQ+ + + ++ HRD+ +N+L+ V+K+CDFG A+ ++ V Sbjct: 243 EDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTH-GKVVKICDFGLARDIMSDSNYVV 301 Query: 216 YICSRY---YRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIK 271 +R + APE +F YT DVWS G +L E+ G +PG ++I+ Sbjct: 302 RGNARLPVKWMAPESLF-EGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQ 360 Query: 272 VLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRL 320 + P Y + I W F R P L S L Sbjct: 361 -------NGFKMDQPFYATEEIYIIMQSCWA--FDSRKRPSFPNLTSFL 400 Score = 70.8 bits (172), Expect = 9e-13, Method: Composition-based stats. Identities = 29/119 (24%), Positives = 48/119 (40%), Gaps = 18/119 (15%) Query: 51 PQEVSYTDTKVIGNGSFGVVYQAK---LCDSGE--LVAIKKVLQ-----DKRFKNRELQI 100 P+E + KV+G+G+FG V A + +G VA+K + + ++ EL++ Sbjct: 63 PRE-NLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKM 121 Query: 101 MRKL-DHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYV 158 M +L H NIV L SG + L+ +Y R K + Sbjct: 122 MTQLGSHENIVNLLGACTLSGP------IYLIFEYCCYGDLLNYLRSKREKFHRTWTEI 174 >2CHL-A nrPDB Length = 351 Score = 132 bits (331), Expect = 4e-31, Method: Composition-based stats. Identities = 56/282 (19%), Positives = 105/282 (37%), Gaps = 26/282 (9%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKK--VLQDKRFKNRELQIMRKLDHCNIVRL 112 ++ K IG G+FG + K + E VAIK + + E + ++L + + Sbjct: 31 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGIPQ 90 Query: 113 RYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYI 172 Y+F G+ Y +VL+ + ++ + R T + V + QL + Y+ Sbjct: 91 VYYFGPCGK-----YNAMVLELLGPSLEDLFDLCDR---TFSLKTVLMIAIQLISRMEYV 142 Query: 173 HSFGICHRDIKPQNLLLDPDTA----VLKLCDFGSAKQLVRGE--------PNVSYICSR 220 HS + +RD+KP+N L+ V+ + DF AK+ + E + S + Sbjct: 143 HSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTA 202 Query: 221 YYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPG---DSGVDQLVEIIKVLGTPT 277 Y + G + D+ + G + L G + G D+ ++ +I Sbjct: 203 RYMSINTHLGKEQ-SRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATP 261 Query: 278 REQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSR 319 E + E P + + + K L R Sbjct: 262 IEVLCENFPEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDR 303 >2C47-A nrPDB Length = 313 Score = 130 bits (328), Expect = 9e-31, Method: Composition-based stats. Identities = 55/276 (19%), Positives = 106/276 (38%), Gaps = 34/276 (12%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKK--VLQDKRFKNRELQIMRKLDHCNIVRL 112 ++ K IG G+FG + K + E VAIK + + E + ++L V Sbjct: 5 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLSATEGVPQ 64 Query: 113 RYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYI 172 Y+F G+ Y +VL+ + ++ + R T + V + QL + Y+ Sbjct: 65 VYYFGPCGK-----YNAMVLELLGPSLEDLFDLCDR---TFTLKTVLMIAIQLITRMEYV 116 Query: 173 HSFGICHRDIKPQNLLL----DPDTAVLKLCDFGSAKQLVRGE--------PNVSYICSR 220 H+ + +RD+KP+N L+ + + DFG AK+ + E + S + Sbjct: 117 HTKSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTA 176 Query: 221 YYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPG---DSGVDQLVEI-------- 269 Y + G + D+ + G + L G + G D+ ++ +I Sbjct: 177 RYMSINTHLGKEQ-SRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATP 235 Query: 270 IKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVF 305 I+VL E++ F + + + + Sbjct: 236 IEVLCENFPEEMATYLRYVRRLDFFEKPDYDYLRKL 271 >4TN6-A nrPDB Length = 318 Score = 129 bits (325), Expect = 2e-30, Method: Composition-based stats. Identities = 56/248 (22%), Positives = 96/248 (38%), Gaps = 24/248 (9%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKK--VLQDKRFKNRELQIMRKLDHCNIVRL 112 Y + IG+GSFG +Y +GE VAIK V + E +I + + + Sbjct: 8 RYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQGGVGIPT 67 Query: 113 RYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYI 172 + + G+ Y +V++ + ++ + SR + V L Q+ + YI Sbjct: 68 IRWCGAEGD-----YNVMVMELLGPSLEDLFNFCSR---KFSLKTVLLLADQMISRIEYI 119 Query: 173 HSFGICHRDIKPQNLL--LDPDTAVLKLCDFGSAKQLVRG--------EPNVSYICSRYY 222 HS HRD+KP N L L ++ + DFG AK+ N + + Y Sbjct: 120 HSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARY 179 Query: 223 RAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPG---DSGVDQLVEIIKVLGTPTRE 279 + G + D+ S G VL LG + G + + I + + E Sbjct: 180 ASINTHLGIEQ-SRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIE 238 Query: 280 QIREMNPN 287 + + P+ Sbjct: 239 VLCKGYPS 246 >2CMW-A nrPDB Length = 310 Score = 128 bits (321), Expect = 6e-30, Method: Composition-based stats. Identities = 55/286 (19%), Positives = 106/286 (37%), Gaps = 43/286 (15%) Query: 57 TDTKVIGNGSFGVVYQAKLCDSGELVAIKK--VLQDKRFKNRELQIMRKLDH-----CNI 109 K IG G+FG + K + E VAIK + + E + ++L + Sbjct: 3 RVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLGSAGEGLPQV 62 Query: 110 VRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 169 Y+F G+ Y +VL+ + ++ + R T + V + QL + Sbjct: 63 ----YYFGPCGK-----YNAMVLELLGPSLEDLFDLCDR---TFTLKTVLMIAIQLLSRM 110 Query: 170 AYIHSFGICHRDIKPQNLLL----DPDTAVLKLCDFGSAKQLVRGE--------PNVSYI 217 Y+HS + +RD+KP+N L+ + V+ + DFG AK+ + E + S Sbjct: 111 EYVHSKNLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSLT 170 Query: 218 CSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPG---DSGVDQLVEI----- 269 + Y + G + D+ + G + L G + G D+ ++ +I Sbjct: 171 GTARYMSINTHLGKEQ-SRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKR 229 Query: 270 ---IKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPE 312 I+ L E++ F + + + + + Sbjct: 230 NTPIEALCENFPEEMATYLRYVRRLDFFEKPDYEYLRTLFTDLFEK 275 >2PZI-A nrPDB Length = 681 Score = 127 bits (320), Expect = 7e-30, Method: Composition-based stats. Identities = 64/256 (25%), Positives = 113/256 (44%), Gaps = 23/256 (8%) Query: 44 PGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCD-SGELVAIKKVLQD-----KRFKNRE 97 P P Y I +G G +Y A + +G V +K ++ + E Sbjct: 70 PQLNPGDIVAGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAE 129 Query: 98 LQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIY 157 Q + ++ H +IV++ F + D V +V++YV + Q LPV Sbjct: 130 RQFLAEVVHPSIVQIFNFVEHTDRHGDPV-GYIVMEYVGGQSLK-----RSKGQKLPVAE 183 Query: 158 VKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYI 217 Y+ ++ +L+Y+HS G+ + D+KP+N++L + LKL D G + R Sbjct: 184 AIAYLLEILPALSYLHSIGLVYNDLKPENIMLTEEQ--LKLIDLG---AVSRINSFGYLY 238 Query: 218 CSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVE---IIKVLG 274 + ++APE++ T T + D+++ G LA L L P G VD L E ++K Sbjct: 239 GTPGFQAPEIV--RTGPTVATDIYTVGRTLAALTLDLPTRNGR-YVDGLPEDDPVLKTYD 295 Query: 275 TPTREQIREMNPNYTE 290 + R R ++P+ + Sbjct: 296 SYGRLLRRAIDPDPRQ 311 >4Y12-A nrPDB Length = 375 Score = 127 bits (319), Expect = 8e-30, Method: Composition-based stats. Identities = 64/256 (25%), Positives = 113/256 (44%), Gaps = 23/256 (8%) Query: 44 PGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCD-SGELVAIKKVLQD-----KRFKNRE 97 P P Y I +G G +Y A + +G V +K ++ + E Sbjct: 109 PQLNPGDIVAGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAE 168 Query: 98 LQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIY 157 Q + ++ H +IV++ F + D V +V++YV + Q LPV Sbjct: 169 RQFLAEVVHPSIVQIFNFVEHTDRHGDPV-GYIVMEYVGGQSLK-----RSKGQKLPVAE 222 Query: 158 VKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYI 217 Y+ ++ +L+Y+HS G+ + D+KP+N++L + LKL D G + R Sbjct: 223 AIAYLLEILPALSYLHSIGLVYNDLKPENIMLTEEQ--LKLIDLG---AVSRINSFGYLY 277 Query: 218 CSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVE---IIKVLG 274 + ++APE++ T T + D+++ G LA L L P G VD L E ++K Sbjct: 278 GTPGFQAPEIV--RTGPTVATDIYTVGRTLAALTLDLPTRNGR-YVDGLPEDDPVLKTYD 334 Query: 275 TPTREQIREMNPNYTE 290 + R R ++P+ + Sbjct: 335 SYGRLLRRAIDPDPRQ 350 >5X18-A nrPDB Length = 295 Score = 126 bits (317), Expect = 1e-29, Method: Composition-based stats. Identities = 56/251 (22%), Positives = 95/251 (37%), Gaps = 28/251 (11%) Query: 54 VSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN--RELQIMRKLDH-CNIV 110 + Y K IG GSFGV+++ +G VAIK + E + + L+ NI Sbjct: 7 LHYKIGKKIGEGSFGVLFEGTNMINGVPVAIKFEPRKTEAPQLRDEYKTYKILNGTPNI- 65 Query: 111 RLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLA 170 Y+F G ++ LV+D + ++ + R V V Q+ + Sbjct: 66 PYAYYFGQEG-----LHNILVIDLLGPSLEDLFDWCGR---KFSVKTVVQVAVQMITLIE 117 Query: 171 YIHSFGICHRDIKPQNLLL----DPDTAVLKLCDFGSAKQLVRGE--------PNVSYIC 218 +H+ + +RDIKP N L+ PD + L DFG AKQ + S Sbjct: 118 DLHAHDLIYRDIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRDPKTKQHIPYREKKSLSG 177 Query: 219 SRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPG---DSGVDQLVEIIKVLGT 275 + Y + G + D+ + G V L G + G + + +I + + Sbjct: 178 TARYMSINTHLGREQ-SRRDDMEALGHVFFYFLRGHLPWQGLKAPNNKQKYEKIGEKKRS 236 Query: 276 PTREQIREMNP 286 + + P Sbjct: 237 TNVYDLAQGLP 247 >5FQD-C nrPDB Length = 341 Score = 126 bits (316), Expect = 2e-29, Method: Composition-based stats. Identities = 48/206 (23%), Positives = 80/206 (38%), Gaps = 22/206 (10%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNR--ELQIMRKLDHCNIVRLR 113 Y + IG+GSFG +Y A +GE VA+K Q R E ++ + L Sbjct: 21 YKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQ-----GGV 75 Query: 114 YFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIH 173 + +++ Y LV+D + ++ + SR + V + Q+ + Y+H Sbjct: 76 GIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSR---RFTMKTVLMLADQMISRIEYVH 132 Query: 174 SFGICHRDIKPQNLLLDPDTAVLK--LCDFGSAKQLVRGEPN--------VSYICSRYYR 223 + HRDIKP N L+ K L DFG AK+ + + Y Sbjct: 133 TKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYA 192 Query: 224 APELIFGATDYTSSIDVWSAG-CVLA 248 + G + D+ S G ++ Sbjct: 193 SINAHLGIEQ-SRRDDMESLGYVLMY 217 >3SV0-A nrPDB Length = 483 Score = 125 bits (315), Expect = 3e-29, Method: Composition-based stats. Identities = 60/267 (22%), Positives = 97/267 (36%), Gaps = 22/267 (8%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKK--VLQDKRFKNRELQIMRKLDHCNIVRLR 113 + + IG+GSFG +Y + E VAIK V E +I R L + Sbjct: 9 FRLGRKIGSGSFGEIYLGTNIQTNEEVAIKLENVKTKHPQLLYESKIYRILQGGTGIPNV 68 Query: 114 YFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIH 173 +F G+ Y LV+D + ++ + SR L + V + Q+ + ++H Sbjct: 69 RWFGVEGD-----YNVLVMDLLGPSLEDLFNFCSR---KLSLKTVLMLADQMINRVEFVH 120 Query: 174 SFGICHRDIKPQNLL--LDPDTAVLKLCDFGSAKQLVRGE--------PNVSYICSRYYR 223 S HRDIKP N L L + + DFG AK+ N + + Y Sbjct: 121 SKSFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDTSTHQHIPYRENKNLTGTARYA 180 Query: 224 APELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIRE 283 + G + D+ S G VL L G + G + + K+ I Sbjct: 181 SVNTHLGIEQ-SRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKYEKISEKKVATSIEA 239 Query: 284 MNPNYTEFKFPQIKAHPWTKVFRPRTP 310 + Y +F + + F + Sbjct: 240 LCRGYPT-EFASYFHYCRSLRFDDKPD 265 >5CEK-A nrPDB Length = 263 Score = 125 bits (313), Expect = 4e-29, Method: Composition-based stats. Identities = 58/307 (18%), Positives = 101/307 (32%), Gaps = 52/307 (16%) Query: 43 TPGQGPDRPQEVSYTDTKVIGNGSFGV---VYQAKLCDSGELVAIKKVLQDKRFKNRELQ 99 PG P + Y + V +A +G + K V K ++++ Sbjct: 1 GPGSAPGPSRIADYLLLPL------AEREHVSRALCIHTGRELRCK-VFPIKHYQDKIRP 53 Query: 100 IMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVK 159 ++ H NI + GE K V+ E + Y R+++ L Sbjct: 54 YIQLPSHSNITGIVEVIL--GETKAYVFF--------EKDFGDMHSYVRSRKRLREEEAA 103 Query: 160 LYMYQLFRSLAYIHSFGICHRDIKPQNLLL-DPDTAVLKLCDFGSAKQL-VRGEPNVSYI 217 Q+ ++A+ H I D+K + + + L+L + + Sbjct: 104 RLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKH 163 Query: 218 CSRYYRAPELIFGATDY-TSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTP 276 Y +PE++ Y + DVWS G +L LL+G+ F +I Sbjct: 164 GCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKI------- 216 Query: 277 TREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACA 336 +F P+ P+A L LL P+ RLT E Sbjct: 217 ----------RRGQFCIPE------------HISPKARCLIRSLLRREPSERLTAPEILL 254 Query: 337 HSFFDEL 343 H +F+ + Sbjct: 255 HPWFESV 261 >6DC0-A nrPDB Length = 292 Score = 125 bits (313), Expect = 4e-29, Method: Composition-based stats. Identities = 48/242 (19%), Positives = 80/242 (33%), Gaps = 42/242 (17%) Query: 105 DHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQ 164 H NI + GE K V+ E + Y R+++ L Q Sbjct: 56 SHSNITGIVEVIL--GETKAYVFF--------EKDFGDMHSYVRSRKRLREEEAARLFKQ 105 Query: 165 LFRSLAYIHSFGICHRDIKPQNLLL-DPDTAVLKLCDFGSAKQL-VRGEPNVSYICSRYY 222 + ++A+ H I D+K + + + L+L + + Y Sbjct: 106 IVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAY 165 Query: 223 RAPELIFGATDY-TSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQI 281 +PE++ Y + DVWS G +L LL+G+ F +I Sbjct: 166 VSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKI------------ 213 Query: 282 REMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFD 341 +F P+ P+A L LL P+ RLT E H +F+ Sbjct: 214 -----RRGQFCIPE------------HISPKARCLIRSLLRREPSERLTAPEILLHPWFE 256 Query: 342 EL 343 + Sbjct: 257 SV 258 >5VDK-A nrPDB Length = 297 Score = 125 bits (313), Expect = 5e-29, Method: Composition-based stats. Identities = 50/314 (15%), Positives = 103/314 (32%), Gaps = 71/314 (22%) Query: 53 EVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKL-------D 105 E + + + IG G FG VY+ G + AIK+ ++ + E + ++ Sbjct: 14 EKEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSALHEVYAHAVLGH 73 Query: 106 HCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYR-VARHYSRAKQTLPVIYVKLYMYQ 164 H ++VR + ++ ++ + +Y + +++ +K + Q Sbjct: 74 HPHVVRYYSSW------AEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQ 127 Query: 165 LFRSLAYIHSFGICHRDIKPQNLLL-----DPDTAVL-----------------KLCDFG 202 + L YIH+ + H DIKP N+ + + V+ K+ D G Sbjct: 128 ISLGLNYIHNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGDLG 187 Query: 203 SAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSG 262 A + + A E++ + D+++ G +A + G P + Sbjct: 188 HATSI---NKPKVEEGDSRFLANEILQEDYRHLPKADIFALGLTIA-VAAGAESLPTNGA 243 Query: 263 VDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLE 322 IR+ N FP + +L +++ Sbjct: 244 --------------AWHHIRKGN-------FPDVPQ---------ELSESFSSLLKNMIQ 273 Query: 323 YTPTARLTPLEACA 336 R + A A Sbjct: 274 PDAEQRPSAA-ALA 286 >4NT4-A nrPDB Length = 312 Score = 124 bits (311), Expect = 8e-29, Method: Composition-based stats. Identities = 54/282 (19%), Positives = 105/282 (37%), Gaps = 40/282 (14%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKK--VLQDKRFKNRELQIMRKL-DH----- 106 ++ K IG G+FG + K + E VAIK + + E + + L H Sbjct: 13 NFRVGKKIGCGNFGELRLGKNLYNNEHVAIKMEPMKSKAPQLHLEYRFYKLLGSHADNAP 72 Query: 107 CNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLF 166 I R+ + G Y +VL+ + ++ + +R + V + QL Sbjct: 73 DGIPRIYHLGTCGGR-----YNAMVLELLGLSLEDLFNICAR---KFSLKTVLMIAKQLL 124 Query: 167 RSLAYIHSFGICHRDIKPQNLLL----DPDTAVLKLCDFGSAKQLVRGE--------PNV 214 + Y+HS + +RD+KP+N L+ ++ + DFG AK+ + + + Sbjct: 125 HRIEYVHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHIPYREHK 184 Query: 215 SYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPG---DSGVDQLVEI-- 269 S + Y + G + D+ + G + L G + G D+ ++ +I Sbjct: 185 SLTGTARYMSINTHMGREQ-SRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGD 243 Query: 270 ------IKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVF 305 I+VL E+ F + + + + Sbjct: 244 TKRATPIEVLCDGHPEEFATYLRYVRRLDFFETPDYDFLRRL 285 >5OAT-A nrPDB Length = 411 Score = 124 bits (311), Expect = 8e-29, Method: Composition-based stats. Identities = 73/335 (21%), Positives = 117/335 (34%), Gaps = 88/335 (26%) Query: 57 TDTKVIGNGSFGVVYQAKLC-----DSGELVAIKKVLQDKRFKNRELQIMR--------- 102 + K I G+ GVVY AK+ D+ A+K + +N ++I++ Sbjct: 14 SLGKPIAKGTNGVVYSAKVKDDETDDNKYPFALKMMFNYDIQENS-MEILKAMYRETVPA 72 Query: 103 -------KLD---------------HCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVY 140 L+ H NIV + F L+ + +++ Sbjct: 73 RMYYSNHDLNNWEIELANRRKHLPPHPNIVAIFSVFTDLYPAALPPRLHPEGEGRNMSLF 132 Query: 141 RVARHYSRAKQTL-----PVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLD---PD 192 + + Y Q+ L + QL +A++ + GI HRD+K NLLLD P+ Sbjct: 133 LLMKRYDCNLQSFLSTAPSTRTSLLLLAQLLEGVAHMTAHGIAHRDLKSDNLLLDTSEPE 192 Query: 193 TAVLKLCDFGSA-------KQLVRGEPNVSYICSRYYRAPELI------FGATDYTSSID 239 + +L + DFG L + + APE+I F +Y+ D Sbjct: 193 SPILVISDFGCCLADKTNGLSLPYTSYEMDKGGNTALMAPEIICQKPGTFSVLNYS-KAD 251 Query: 240 VWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH 299 +W+ G + E+ F G S R N NY E P++ Sbjct: 252 LWAVGAIAYEIFNCHNPFYGPS--------------------RLKNFNYKEGDLPKLP-- 289 Query: 300 PWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEA 334 P AL + LL+ P RL P A Sbjct: 290 -------DEVPTVIQALVANLLKRNPNKRLDPEVA 317 >5X1R-A nrPDB Length = 302 Score = 122 bits (307), Expect = 2e-28, Method: Composition-based stats. Identities = 52/301 (17%), Positives = 109/301 (36%), Gaps = 59/301 (19%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN------------------- 95 + + IG G FG+VY+A +AIK+ + K Sbjct: 22 EFEIQEAIGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAKRNDDLSIGLRGERFGKTFQA 81 Query: 96 ------RELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRA 149 +E +++ + H ++ + F+ +G + + T + + ++ Sbjct: 82 GLNSFIQEARLLARFSHPGLLHVLRFWEENGTA------YMGTQFYSGTTLKNLQ--AQQ 133 Query: 150 KQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVR 209 + + +++ + LF ++ IH G HRDI N+ + ++ + L DFGSA++ + Sbjct: 134 PEKIDEAWIRRLLPPLFSAINTIHQEGYLHRDISLDNIQI-QESQLPVLLDFGSARKEIG 192 Query: 210 GEPNVSYICSRYYRAPELIFGATDYTSSI--------DVWSAGCVLAELLLGQPIFPGDS 261 + + I + AP YT + D+++ G VL L++G P Sbjct: 193 NLSDETEIVLKPGFAP-----IEQYTENSDGEQGPWTDIYALGAVLHTLIVGSPPP---- 243 Query: 262 GVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLL 321 + V+ + + ++ +P P+ I + LL Sbjct: 244 --------VSVVRSIEDSYQPLTERRPAGYSPELLRTVDRALALKPEDRPQTIDEMAELL 295 Query: 322 E 322 E Sbjct: 296 E 296 >5UV4-A nrPDB Length = 311 Score = 120 bits (301), Expect = 1e-27, Method: Composition-based stats. Identities = 48/214 (22%), Positives = 92/214 (42%), Gaps = 15/214 (7%) Query: 51 PQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVL----QDKRFKNRELQIMRKLDH 106 +E+S ++IG G Y+A L D+G ++ +K + + K+ +RE++ + + H Sbjct: 22 AEELSCAPAEIIGRSCHGTSYKATL-DNGYMLTVKWLKEGFAKSKKEFSREIKKLGSVRH 80 Query: 107 CNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYR--VARHYSRAKQTLPVIYVKLYMYQ 164 N+V LR +++ E + ++ DY T ++ R L Sbjct: 81 PNLVPLRGYYWGPKEHER----IMISDYADATSLSTYLSEFDERNLPPLSAGQRLNIAID 136 Query: 165 LFRSLAYIHSFGIC-HRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGE--PNVSYICSRY 221 + R L Y+H+ + H +IK N+L+ T + D+ + + V + Sbjct: 137 IARCLDYLHNERVIPHGNIKSSNVLIQNSTPSALVTDYSLHRLMTPIGMAEQVLNAGALG 196 Query: 222 YRAPELIFGATDY-TSSIDVWSAGCVLAELLLGQ 254 Y PE + + DV++ G +L ELL G+ Sbjct: 197 YSPPEFSSTSKPCPSLKSDVYAFGVILLELLTGK 230 >4IX6-A nrPDB Length = 350 Score = 118 bits (296), Expect = 4e-27, Method: Composition-based stats. Identities = 83/356 (23%), Positives = 129/356 (36%), Gaps = 66/356 (18%) Query: 32 KDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDK 91 + G K TPG P + +G+G+FG V++ + V +K D Sbjct: 4 RGGPKTLRR--TPGVEPKDIR----VLPGPLGSGNFGTVFRGVFKGD-QDVVLKNAKADV 56 Query: 92 RFKNRELQIMRKLD---HCN----IVRLRYFFYSSGEKKDEVYLNLVLD-----YVPETV 139 L+ ++ H N R + E+Y + + + E Sbjct: 57 MAAEELLECEMDVNYHVHANAKGTCARFMGCIELGAKDGGEIYNGTLTEGLWLMWANEGE 116 Query: 140 YRVARHYSRAKQTLPVIYV----------KLYMYQLFRSLAYIHSFGICHRDIKPQN-LL 188 V R L K M +L SLA +H G+ HRD+KP N + Sbjct: 117 NTVEALMRRGTAPLATAMACADATELGVTKKAMRELLGSLARLHECGVVHRDVKPANLIA 176 Query: 189 LDPDTAVLKLCDFGSAKQLVRGEPNVSYICS------RYYRAPELIF---GATDYTS--- 236 + D VLKL D G+A + ++Y RY +A EL G+ T Sbjct: 177 AEKDGGVLKLIDLGAAALCLPLPETLNYYPGDGPADPRYAKADELYLLPPGSPRPTKDNA 236 Query: 237 ----------SIDVWSAGCVLAEL-LLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMN 285 D WSAGCV+ +L ++G D+G+++ + K +G E + Sbjct: 237 AKLWEAHKPDRFDSWSAGCVMLQLAVVGL---RTDAGLERFLADYKAVGYDVNAFRGEKS 293 Query: 286 PNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFD 341 Y F + A+ LC RL+E AR + A +H+FFD Sbjct: 294 GEYGTMDFAALDANGGA----------GWDLCQRLMEAERDARASCEAALSHAFFD 339 >4L00-A nrPDB Length = 304 Score = 118 bits (296), Expect = 4e-27, Method: Composition-based stats. Identities = 63/332 (18%), Positives = 116/332 (34%), Gaps = 72/332 (21%) Query: 49 DRPQEVSYTDTKVIGNGSFGVVYQAKLCD------SGELVAIKKVLQDKRFKNRELQ--- 99 DR + + +G G+ +Y L D + E IK +L+ +R++ Sbjct: 20 DRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAF 79 Query: 100 -----IMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLP 154 +MR++ H +IV L E +V ++V + H R L Sbjct: 80 FEAASMMRQVSHKHIVYLYGVCVRDVEN------IMVEEFVEGGPLDLFMH--RKSDVLT 131 Query: 155 VIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDT------AVLKLCDFGSAKQLV 208 + QL +L+Y+ + H ++ +NLLL + +KL D G ++ Sbjct: 132 TPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVL 191 Query: 209 RGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLV 267 + + I + APE + + + + + D WS G L E+ G+ + ++ Sbjct: 192 SRQECIERI---PWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIE--- 245 Query: 268 EIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTA 327 + +F + + P T + E L +R + Y P Sbjct: 246 ----------------------KERFYESRCRPVTPSCK-----ELADLMTRCMNYDPNQ 278 Query: 328 RLTPLEACAHSFFDEL-RDPNVKLPNGRDTPA 358 R FF + RD N D + Sbjct: 279 R---------PFFRAIMRDINKLEEQNPDIVS 301 >4MWI-A nrPDB Length = 294 Score = 118 bits (296), Expect = 5e-27, Method: Composition-based stats. Identities = 51/282 (18%), Positives = 93/282 (32%), Gaps = 51/282 (18%) Query: 71 YQAKLCDSGELVAIKKVLQ--------DKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEK 122 Y+ + + VAIK + ++ N+E++ M+K + NI+R+ E Sbjct: 41 YKGEYHRA--PVAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICID--ET 96 Query: 123 KDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGI--CHR 180 ++V++Y R ++ L + + + R L +H H Sbjct: 97 VTPPQFSIVMEYCELGT---LRELLDREKDLTLGKRMVLVLGAARGLYRLHHSEAPELHG 153 Query: 181 DIKPQNLLLDPDTAVLKLCDFGSAK-----QLVRGEPNVSYICSRYYRAP-ELIFGATDY 234 I+ N L+ +KL F K L + S Y +P EL Y Sbjct: 154 KIRSSNFLVTQ-GYQVKLAGFELRKTQTSMSLGTTREKTDRVKSTAYLSPQELEDVFYQY 212 Query: 235 TSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFP 294 +++S G VL E+ G F G + E+IR++ Sbjct: 213 DVKSEIYSFGIVLWEIATGDIPFQGCN----------------SEKIRKL---------- 246 Query: 295 QIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACA 336 + + P E + + P+ R + E Sbjct: 247 -VAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILK 287 >5M07-A nrPDB Length = 276 Score = 117 bits (294), Expect = 7e-27, Method: Composition-based stats. Identities = 53/211 (25%), Positives = 84/211 (39%), Gaps = 31/211 (14%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVL-------QDKRFKNRELQIMRKLDHCN 108 YT +++G + G VY + A+K + + +R RE ++ +L H + Sbjct: 32 YTVVRMLGASAMGEVYLVQHPGFPGWQALKVLSPAMAADDEFRRRFQRETEVAARLFHPH 91 Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRS 168 I+ + G+ L + +DYV + + R LPV V + + + Sbjct: 92 ILEVHDRGEFDGQ------LWIAMDYV-DGIDATQHMADRFPAVLPVGEVLAIVTAVAGA 144 Query: 169 LAYIHSFGICHRDIKPQNLLLDPDTA---VLKLCDFGSAKQLVRGEPNVSYICSRYYRAP 225 L Y H G+ HRD+ P N++L +A + L DFG A Q Y AP Sbjct: 145 LDYAHQRGLLHRDVNPANVVLTSQSAGDQRILLADFGIASQ-------------PSYPAP 191 Query: 226 ELIFGATDYTSSIDVWSAGCVLAELLLGQPI 256 EL GA D D ++ L G P Sbjct: 192 ELSAGA-DVDGRADQYALALTAIHLFAGAPP 221 >4XHH-A nrPDB Length = 403 Score = 117 bits (294), Expect = 8e-27, Method: Composition-based stats. Identities = 55/270 (20%), Positives = 99/270 (36%), Gaps = 28/270 (10%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIK--KVLQDKRFKNRELQIMRKLDHCNIVRLR 113 + + IG+GSFG +Y SGE VAI+ + + E ++ + L + Sbjct: 9 FRIGRKIGSGSFGDIYHGTNLISGEEVAIRLESIRSRHPQLDYESRVYKYLSGGVGIPFI 68 Query: 114 YFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIH 173 +F GE Y +V+D + ++ + + R V + Q+ + YIH Sbjct: 69 RWFGREGE-----YNAMVIDLLGPSLEDLFNYCHR---KFSFKTVIMLALQMICRVQYIH 120 Query: 174 SFGICHRDIKPQNLL--LDPDTAVLKLCDFGSAKQL--------VRGEPNVSYICSRYYR 223 HRDIKP N L + + + + DFG +K+ + N S + Y Sbjct: 121 GRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTARYA 180 Query: 224 APELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPG---DSGVDQLVEIIKVLGTPTREQ 280 + G + D+ S G +L G + G + + I++ + E Sbjct: 181 SVNTHLGIEQ-SRRDDLESLGYMLIYFCKGSLPWQGLKATTKKQKYDRILEKKLCISVET 239 Query: 281 IREMNPNYTEFKFPQIKAHPWTKVFRPRTP 310 + P +F + + F R Sbjct: 240 LCAGLP----LEFSEYMNYCRNLKFDERPD 265 >4XHL-A nrPDB Length = 394 Score = 115 bits (289), Expect = 3e-26, Method: Composition-based stats. Identities = 58/270 (21%), Positives = 101/270 (37%), Gaps = 28/270 (10%) Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIK--KVLQDKRFKNRELQIMRKLDHCNIVRLR 113 + + IG+GSFG +Y SGE VAI+ + + E ++ R L + Sbjct: 9 FRIGRKIGSGSFGDIYHGTNLISGEEVAIRLESIRSRHPQLDYESRVYRYLSGGVGIPFI 68 Query: 114 YFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIH 173 +F GE Y +V+D + ++ + + R V + Q+F + YIH Sbjct: 69 RWFGREGE-----YNAMVIDLLGPSLEDLFNYCHR---RFSFKTVIMLALQMFCRIQYIH 120 Query: 174 SFGICHRDIKPQNLL--LDPDTAVLKLCDFGSAKQL--------VRGEPNVSYICSRYYR 223 HRDIKP N L + + + + DFG +K+ + N S + Y Sbjct: 121 GRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTARYA 180 Query: 224 APELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPG---DSGVDQLVEIIKVLGTPTREQ 280 + G + D+ S G VL G + G + + I++ + E Sbjct: 181 SVNTHLGIEQ-SRRDDLESLGYVLIYFCKGSLPWQGLKATTKKQKYDRIMEKKLNVSVET 239 Query: 281 IREMNPNYTEFKFPQIKAHPWTKVFRPRTP 310 + P +F + A+ F + Sbjct: 240 LCSGLP----LEFQEYMAYCKNLKFDEKPD 265 >1CSN-A nrPDB Length = 298 Score = 115 bits (288), Expect = 3e-26, Method: Composition-based stats. Identities = 57/286 (19%), Positives = 106/286 (37%), Gaps = 27/286 (9%) Query: 54 VSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKV--LQDKRFKNRELQIMRKLDHCNIVR 111 V Y + IG GSFGV+++ + + VAIK D E + + L C + Sbjct: 10 VHYKVGRRIGEGSFGVIFEGTNLLNNQQVAIKFEPRRSDAPQLRDEYRTYKLLAGCTGIP 69 Query: 112 LRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAY 171 Y+F G ++ LV+D + ++ + R V V + Q+ + Sbjct: 70 NVYYFGQEG-----LHNVLVIDLLGPSLEDLLDLCGR---KFSVKTVAMAAKQMLARVQS 121 Query: 172 IHSFGICHRDIKPQNLLL----DPDTAVLKLCDFGS--------AKQLVRGEPNVSYICS 219 IH + +RDIKP N L+ + ++ + DFG KQ + + + Sbjct: 122 IHEKSLVYRDIKPDNFLIGRPNSKNANMIYVVDFGMVKFYRDPVTKQHIPYREKKNLSGT 181 Query: 220 RYYRAPELIFGATDYTSSIDVWSAG-CVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTR 278 Y + G + D+ + G + L G + G + ++ Sbjct: 182 ARYMSINTHLGREQ-SRRDDLEALGHVFMY-FLRGSLPWQGLKAATNKQKYERIGEKKQS 239 Query: 279 EQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIA-LCSRLLEY 323 +RE+ + E +F + + F + + L S++LE Sbjct: 240 TPLRELCAGFPE-EFYKYMHYARNLAFDATPDYDYLQGLFSKVLER 284 >4BTF-A nrPDB Length = 469 Score = 112 bits (281), Expect = 2e-25, Method: Composition-based stats. Identities = 50/283 (17%), Positives = 91/283 (32%), Gaps = 49/283 (17%) Query: 68 GVVYQAKLCDSGELVAIKKVLQDKRF--------KNRELQIMRKLDHCNIVRLRYFFYSS 119 +Y+ + S V IK + N E++ M+K D NI+R+ Sbjct: 209 STIYRGEYHRS--PVTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICIDQ 266 Query: 120 GEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICH 179 K E ++V++Y R ++ L + L + + R L +H H Sbjct: 267 TVKPPE--FSIVMEYCELGT---LRELLDREKDLTMSVRSLLVLRAARGLYRLHHSETLH 321 Query: 180 RDIKPQNLLLDPDTAVLKLCDFGSAKQLVR-----GEPNVSYICSRYYRAPELIFG-ATD 233 R+I + L+ +KL F +K S Y +PE + Sbjct: 322 RNISSSSFLV-AGGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCL 380 Query: 234 YTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKF 293 Y +++S G VL E+ G+ F G ++IRE+ + Sbjct: 381 YDIKAEIYSFGIVLWEIATGKIPFEGCD----------------SKKIRELVAEDKK--- 421 Query: 294 PQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACA 336 + P + + + P+ R + Sbjct: 422 --------QEPVGQDCPELLREIINECRAHEPSQRPSVDGILE 456 >4M69-B nrPDB Length = 283 Score = 111 bits (278), Expect = 6e-25, Method: Composition-based stats. Identities = 50/283 (17%), Positives = 91/283 (32%), Gaps = 49/283 (17%) Query: 68 GVVYQAKLCDSGELVAIKKVLQDKRF--------KNRELQIMRKLDHCNIVRLRYFFYSS 119 +Y+ + S V IK + N E++ M+K D NI+R+ Sbjct: 23 STIYRGEYHRS--PVTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICIDQ 80 Query: 120 GEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICH 179 K E ++V++Y R ++ L + L + + R L +H H Sbjct: 81 TVKPPE--FSIVMEYCELGT---LRELLDREKDLTMSVRSLLVLRAARGLYRLHHSETLH 135 Query: 180 RDIKPQNLLLDPDTAVLKLCDFGSAKQLVR-----GEPNVSYICSRYYRAPELIFG-ATD 233 R+I + L+ +KL F +K S Y +PE + Sbjct: 136 RNISSSSFLV-AGGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCL 194 Query: 234 YTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKF 293 Y +++S G VL E+ G+ F G ++IRE+ + Sbjct: 195 YDIKAEIYSFGIVLWEIATGKIPFEGCD----------------SKKIRELVAEDKK--- 235 Query: 294 PQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACA 336 + P + + + P+ R + Sbjct: 236 --------QEPVGQDCPELLREIINECRAHEPSQRPSVDGILE 270 >5USZ-A nrPDB Length = 289 Score = 108 bits (269), Expect = 5e-24, Method: Composition-based stats. Identities = 50/289 (17%), Positives = 100/289 (34%), Gaps = 58/289 (20%) Query: 60 KVIGNGSFGVVYQAKLCDSGEL-------VAIKKVLQDKR----FKNRELQIMRKLDHCN 108 + +G G+F +++ + G+ V +K + + R +M KL H + Sbjct: 14 ESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKH 73 Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRS 168 +V E LV ++V + + + K + +++ QL + Sbjct: 74 LVLNYGVCVCGDEN------ILVQEFVK--FGSLDTYLKKNKNCINILWKLEVAKQLAAA 125 Query: 169 LAYIHSFGICHRDIKPQNLLL-------DPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY 221 + ++ + H ++ +N+LL + +KL D G + ++ + I Sbjct: 126 MHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERI---P 182 Query: 222 YRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQI 281 + PE I + + D WS G L E+ G GD + L K+ R Q+ Sbjct: 183 WVPPECIENPKNLNLATDKWSFGTTLWEICSG-----GDKPLSALDSQRKLQFYEDRHQL 237 Query: 282 REMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLT 330 P+ A L + ++Y P R + Sbjct: 238 PA-----------------------PKAAELA-NLINNCMDYEPDHRPS 262 >6G4J-A nrPDB Length = 315 Score = 106 bits (264), Expect = 2e-23, Method: Composition-based stats. Identities = 47/233 (20%), Positives = 96/233 (41%), Gaps = 19/233 (8%) Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRY 114 +YT K +G G+ G+VY A+ D VA+K V D E+ +++ V + Sbjct: 27 TYTLRKQLGKGANGIVYLAETSDGH--VALK-VSDDSLSITSEVNVLKSFSKAQSVTMGP 83 Query: 115 FFYSSGEKKDEVYLNLV----LDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLA 170 F+ + + V ++Y+ + + ++ S ++ + M QL SL+ Sbjct: 84 SFFDTDDAYIPSANTKVSFYAMEYIKGPL--LLKYVSDKG----AEWIPVLMIQLLSSLS 137 Query: 171 YIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFG 230 +H G D+KP NL++ A ++ D G + R + R Y +G Sbjct: 138 VLHQQGWIFGDLKPDNLIVTGPPARIRCIDVGGTTKEGRAIKEYTEFYDRGYWG----YG 193 Query: 231 ATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIRE 283 S D+++ ++ + + + +QL +I+ G P ++ ++ Sbjct: 194 TRKAEPSYDLFAVAMIMINSVHKKEFKKTNQPKEQLRSLIE--GNPLLQKYKK 244 >6EQI-C nrPDB Length = 433 Score = 101 bits (251), Expect = 7e-22, Method: Composition-based stats. Identities = 61/353 (17%), Positives = 111/353 (31%), Gaps = 106/353 (30%) Query: 54 VSYTDTKVIGNGSFGVVYQAKLCD--SGEL---VAIKKVLQDKRFKN---------RE-- 97 + I G VVY AKL + S +L +A+K + N RE Sbjct: 15 DELDLGEPIAKGCNAVVYSAKLKNVQSNKLAHQLAVKMMFNYDVESNSTAILKAMYRETV 74 Query: 98 -------------LQIMRKLD-----HCNIVRLRYFF---YSSGEKKDEVY--------- 127 ++ + H NIVR+ F + ++Y Sbjct: 75 PAMSYFFNQNLFNIENISDFKIRLPPHPNIVRMYSVFADRIPDLQCNKQLYPEALPPRIN 134 Query: 128 ---------LNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGIC 178 L LV+ T+ R + ++ ++ +L ++A+++ I Sbjct: 135 PEGSGRNMSLFLVMKRYDCTLKEYLRDKTPNMRSSILLLSQLL-----EAVAHMNIHNIS 189 Query: 179 HRDIKPQNLLLDPDTA----VLKLCDFGSA-------KQLVRGEPNVSYICSRYYRAPEL 227 HRD+K N+L+D + + DFG + + +R APE+ Sbjct: 190 HRDLKSDNILVDLSEGDAYPTIVITDFGCCLCDKQNGLVIPYRSEDQDKGGNRALMAPEI 249 Query: 228 I------FGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQI 281 F +Y D+W+ G + E+ F + + Sbjct: 250 ANAKPGTFSWLNY-KKSDLWAVGAIAYEIFNIDNPFYDKT-------------------M 289 Query: 282 REMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEA 334 + ++ +Y E P++ P L S +L + RL A Sbjct: 290 KLLSKSYKEEDLPELP---------DTIPFIIRNLVSNMLSRSTNKRLDCDVA 333 >3REP-A nrPDB Length = 271 Score = 98.9 bits (245), Expect = 3e-21, Method: Composition-based stats. Identities = 42/271 (15%), Positives = 92/271 (33%), Gaps = 47/271 (17%) Query: 68 GVVYQAKLCDSGELVAIKKVLQDKRFKNRELQI----MRKLDHCNIVRLRYFFYSSGEKK 123 G +++ + + +V + KV K+R+ +R H N++ + + Sbjct: 24 GELWKGRWQGNDIVVKVLKVRDWSTRKSRDFNEECPRLRIFSHPNVLPVLGAC----QSP 79 Query: 124 DEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFG-ICHR-D 181 + L+ ++P H + + + R +A++H+ + R Sbjct: 80 PAPHPTLITHWMPYGSLYNVLHEG-TNFVVDQSQAVKFALDMARGMAFLHTLEPLIPRHA 138 Query: 182 IKPQNLLLDPD-TAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYT--SSI 238 + +++++D D TA + + D + + + + + APE + + T S Sbjct: 139 LNSRSVMIDEDMTARISMADVKFS------FQSPGRMYAPAWVAPEALQKKPEDTNRRSA 192 Query: 239 DVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKA 298 D+WS +L EL+ + F S +++ E +R P Sbjct: 193 DMWSFAVLLWELVTREVPFADLSN-------MEIGMKVALEGLRPTIP------------ 233 Query: 299 HPWTKVFRPRTPPEAIALCSRLLEYTPTARL 329 P P L + P R Sbjct: 234 --------PGISPHVSKLMKICMNEDPAKRP 256 >4L68-A nrPDB Length = 340 Score = 98.6 bits (244), Expect = 5e-21, Method: Composition-based stats. Identities = 62/260 (23%), Positives = 97/260 (37%), Gaps = 28/260 (10%) Query: 68 GVVYQAKLCDSGELVAIKKV---LQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKD 124 G Y+A L G +A+K + +R E+ + +L H N+ L F EK Sbjct: 54 GTTYKA-LLPDGSALAVKHLSTCKLGEREFRYEMNQLWELRHSNLAPLLGFCVVEEEK-- 110 Query: 125 EVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFG---ICHRD 181 LV Y+ +R + L R LA++H I H++ Sbjct: 111 ----FLVYKYMSNGTLHSLLDSNRGE--LDWSTRFRIGLGAARGLAWLHHGCRPPILHQN 164 Query: 182 IKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICS-----RYYRAPELIFGATDYTS 236 I +L+D D ++ D G A+ +V + N S + Y APE + Sbjct: 165 ICSSVILIDEDFDA-RIIDSGLARLMVPSDNNESSFMTGDLGEFGYVAPE-YSTTMLASL 222 Query: 237 SIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTR------EQIREMNPNYTE 290 DV+ G VL EL G G+ LV+ +K L + R E IR + Sbjct: 223 KGDVYGLGVVLLELATGLKAVGGEGFKGSLVDWVKQLESSGRIAETFDENIRGKGHDEEI 282 Query: 291 FKFPQIKAHPWTKVFRPRTP 310 KF +I + + + R Sbjct: 283 SKFVEIALNCVSSRPKERWS 302 >5C01-A nrPDB Length = 342 Score = 95.5 bits (236), Expect = 4e-20, Method: Composition-based stats. Identities = 49/276 (17%), Positives = 92/276 (33%), Gaps = 53/276 (19%) Query: 73 AKLCDSGELVAIKKVLQDKRFKN----RELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYL 128 + V +K + +M ++ H ++ + E Sbjct: 101 GRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPEN------ 154 Query: 129 NLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLL 188 +V +YV V R + +P+ + + QL +L+Y+ + + H ++ +N+L Sbjct: 155 IMVTEYVEHGPLDV--WLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNIL 212 Query: 189 L------DPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELI-FGATDYTSSIDVW 241 L + + +KL D G + E V I + APE + GA ++++D W Sbjct: 213 LARLGLAEGTSPFIKLSDPGVGLGALSREERVERI---PWLAPECLPGGANSLSTAMDKW 269 Query: 242 SAGCVLAEL-LLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP 300 G L E+ G+ S + +E + E PQ+ Sbjct: 270 GFGATLLEICFDGEAPLQSRSPSE-------------KEHFYQRQHRLPEPSCPQLAT-- 314 Query: 301 WTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACA 336 L S+ L Y PT R + Sbjct: 315 ---------------LTSQCLTYEPTQRPSFRTILR 335 >4WOV-A nrPDB Length = 317 Score = 95.5 bits (236), Expect = 4e-20, Method: Composition-based stats. Identities = 49/276 (17%), Positives = 92/276 (33%), Gaps = 53/276 (19%) Query: 73 AKLCDSGELVAIKKVLQDKRFKN----RELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYL 128 + V +K + +M ++ H ++ + E Sbjct: 78 GRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPEN------ 131 Query: 129 NLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLL 188 +V +YV V R + +P+ + + QL +L+Y+ + + H ++ +N+L Sbjct: 132 IMVTEYVEHGPLDV--WLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNIL 189 Query: 189 L------DPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELI-FGATDYTSSIDVW 241 L + + +KL D G + E V I + APE + GA ++++D W Sbjct: 190 LARLGLAEGTSPFIKLSDPGVGLGALSREERVERI---PWLAPECLPGGANSLSTAMDKW 246 Query: 242 SAGCVLAEL-LLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP 300 G L E+ G+ S + +E + E PQ+ Sbjct: 247 GFGATLLEICFDGEAPLQSRSPSE-------------KEHFYQRQHRLPEPSCPQLAT-- 291 Query: 301 WTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACA 336 L S+ L Y PT R + Sbjct: 292 ---------------LTSQCLTYEPTQRPSFRTILR 312 >5CLR-A nrPDB Length = 451 Score = 91.2 bits (225), Expect = 7e-19, Method: Composition-based stats. Identities = 44/193 (22%), Positives = 70/193 (36%), Gaps = 19/193 (9%) Query: 71 YQAKLCDSGELVAIKKVLQDKRFKNR---ELQIMRKLDHCNIVRLRYFFYSSGEKKDEVY 127 ++ D G+ +K V D E + KL RL F++ ++ +V+ Sbjct: 96 FKVYALDDGKTYFLKSVKIDAESLTEFTNEKDTLSKLG-----RLVGTFFN---EQTQVH 147 Query: 128 LNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNL 187 L + R V M + + H G+ HRD+KP N+ Sbjct: 148 YILTTFIKGIDLSRYKNALPLNVNLKHFWEVLGIMISVCHQVKQFHELGLIHRDLKPGNI 207 Query: 188 LLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPEL--IFGATDYTSSIDVWSAGC 245 +LD D L DFGS+ EP + + Y APEL ++ D+++ Sbjct: 208 MLDADMQ-CHLVDFGSSSS--DKEPKPASWGTASYLAPELNAQEDFIAFSQVSDLFALAY 264 Query: 246 VLAELLLGQPIFP 258 L EL F Sbjct: 265 SLDELFN---PFR 274 >6J6I-B nrPDB Length = 351 Score = 90.5 bits (223), Expect = 1e-18, Method: Composition-based stats. Identities = 41/190 (21%), Positives = 74/190 (38%), Gaps = 22/190 (11%) Query: 74 KLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLD 133 + +G+ +K+V D R M +H N ++L G + + LV + Sbjct: 91 EDEITGKRHRVKEVYNDIVLSAR----MS--NHSNFLQLL------GCCLEFPFPVLVFE 138 Query: 134 YVPETVY--RVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHS---FGICHRDIKPQNLL 188 + R + + LP ++ ++ Y+H+ I HRD+KP ++ Sbjct: 139 FAEHGAMNQRGGVIVNGEESLLPWSVRLKIGKEIANAVTYLHTAFPKIIIHRDVKPMHVF 198 Query: 189 LDPDTAVLKLCDFGSAKQLVRGEPNVS---YICSRYYRAPELIFGATDYTSSIDVWSAGC 245 LD + KL D + L G+ + + + Y P L T DV+S G Sbjct: 199 LDKNWTA-KLSDLSFSISLPEGKSRIEAEWVLGTFGYIDP-LYHKTCFVTEYTDVYSFGI 256 Query: 246 VLAELLLGQP 255 L ++ G+P Sbjct: 257 CLLVIITGKP 266 >4I94-A nrPDB Length = 300 Score = 89.7 bits (221), Expect = 2e-18, Method: Composition-based stats. Identities = 57/269 (21%), Positives = 95/269 (35%), Gaps = 41/269 (15%) Query: 69 VVYQAKLCDSGELVAIKKVLQ----DKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKD 124 VVY+ KL ++ +A+K+ + D R E + + +L + + L Y E+ Sbjct: 44 VVYKGKL-ENQRRIAVKRFNRKSWPDSRQFLEEAKAVGQLRNHRMANLLGCCYEDEERL- 101 Query: 125 EVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFG-ICHRDIK 183 L+ +++P + Q + + ++L Y S G + D+ Sbjct: 102 -----LIAEFMPNETLA-KHLFHWESQPMKWAMRLRVALHIAQALEYCTSKGRALYHDLN 155 Query: 184 PQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSA 243 +L D D +L FG K G SY + + PE + T ++S Sbjct: 156 AYRVLFDDDAN-PRLSCFGLMKNSRDG---KSYSTNLAFTPPEYLR-TGRVTPESVIYSF 210 Query: 244 GCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTK 303 G +L +LL G+ I P + IR+ N + Sbjct: 211 GTLLLDLLSGKHIPPSH----------------ALDLIRDRN-------IQMLMDSGLEG 247 Query: 304 VFRPRTPPEAIALCSRLLEYTPTARLTPL 332 F E I L SR L+Y P R P Sbjct: 248 QFSSDDGTELIRLASRCLQYEPRERPNPK 276 >5UU1-A nrPDB Length = 324 Score = 84.3 bits (207), Expect = 1e-16, Method: Composition-based stats. Identities = 49/239 (20%), Positives = 88/239 (36%), Gaps = 30/239 (12%) Query: 45 GQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVA---IKKVLQDKRFKNRELQIM 101 G+ D + + K IG+G FG++Y A + E A +K Q+ EL+ Sbjct: 7 GKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFY 66 Query: 102 RKLDHCNIVRL-----------RYFFYSSG--EKKDEVYLNLVLDYVPETVYRVARHYSR 148 +++ + ++ FY SG E K Y +V++ + + ++ S Sbjct: 67 QRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKI----SG 122 Query: 149 AKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLD-PDTAVLKLCDFGSAKQL 207 T V ++ L YIH H DIK NLLL + + L D+G + + Sbjct: 123 QNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRY 182 Query: 208 VRGEPNVSYI--------CSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFP 258 + Y + + + + G + DV G + L G+ + Sbjct: 183 CPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVAL-SRRSDVEILGYCMLRWLCGKLPWE 240 >4O1O-A nrPDB Length = 717 Score = 78.9 bits (193), Expect = 4e-15, Method: Composition-based stats. Identities = 55/326 (16%), Positives = 100/326 (30%), Gaps = 82/326 (25%) Query: 68 GVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLD-HCNIVRLRYFFYSSGEKKDEV 126 G +Y D + VA+K+ + +E+ ++ + N+V G + D Sbjct: 360 GGIYLGLYED--QEVAVKRFSEGSTRGQQEVSCLQSSRANDNVVTFY------GSESDGS 411 Query: 127 YLNLVLDYVPETV-YRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQ 185 L++ L T+ +A H A + + LF+++ +H G H+D++PQ Sbjct: 412 CLHVCLALCEYTLQEHLANHRGDAVPNEEDESARNILSSLFKAIGELHRSGYSHQDLQPQ 471 Query: 186 NLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAG- 244 N+L+D L DF + + + D+ + G Sbjct: 472 NILIDSKNGTF-LADFDKSIKWAEDPQKIKR----------------------DLEALGL 508 Query: 245 CVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKV 304 VL + + F +K + +V Sbjct: 509 LVLYVV------------------------------------KKGDISFETLKNQSFEEV 532 Query: 305 FRPRTPPEAIALCSRLLEYTP----TARLTPLEACAHSFFDEL---RDPNVKLPNGRDTP 357 + E L L + P RL+ AH FF + N D Sbjct: 533 IQGSPDEETRDLIHHL--FHPGDNVEDRLSS--LLAHPFFWSWESRYRTLRDVGNESDI- 587 Query: 358 ALFNFTTQELSSNPPLATILIPPHAR 383 N ++ L P + L A+ Sbjct: 588 KTRNQNSRILQLLQPGTSELSTSFAQ 613 >4CI6-B nrPDB Length = 643 Score = 77.8 bits (190), Expect = 7e-15, Method: Composition-based stats. Identities = 61/337 (18%), Positives = 109/337 (32%), Gaps = 42/337 (12%) Query: 76 CDSGELVAIKK---VLQDKRFKNREL--QIMRKL-DHCNIVRLRYFFYSSGEKKDEVYLN 129 D LVA K + + F E I + H N+ + + + Y Sbjct: 66 KDKQRLVA-KIERSIAEGHLFAELEAYKHIYKTAGKHPNLANVHGM--AVVPYGNRYYYA 122 Query: 130 LVLDYVPE----TVYRVARHYSRAKQTLPVIY---VKLYMYQLFRSLAYIHSFGICHRDI 182 L++D V R + + Y +K ++L ++ GI H DI Sbjct: 123 LLMDEVDGWRCSDTLRSLADSWKQGKINSEAYWGTIKFIAHRLLDVTNHLAKAGIVHNDI 182 Query: 183 KPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWS 242 KP N++ D + + D G GE + + ++APEL G + DV+ Sbjct: 183 KPGNVVFDRASGEPVVIDLGL--HSRSGEQPKGF--TESFKAPELGVGNLGASEKSDVF- 237 Query: 243 AGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWT 302 V++ LL G F D + + +R + +P Sbjct: 238 --LVVSTLLHGIEGFEKDPEI------------KPNQGLRFITSEPAHVM--DENGYPIH 281 Query: 303 KVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNF 362 + + +L + +R EA H F + + L + Sbjct: 282 RPGIAGVETAYTRFITDILGVSADSRPDSNEARLHEFLSD-----GTIDEESAKQILKDT 336 Query: 363 TTQELSSNPPLATILIPPHARIQAAASPPANATAASD 399 T E+S P + P + R + ++AA+ Sbjct: 337 LTGEMSPLPTDVRRITPYYLRELSDLLRTHLSSAATK 373 >3BYV-A nrPDB Length = 377 Score = 76.2 bits (186), Expect = 2e-14, Method: Composition-based stats. Identities = 62/318 (19%), Positives = 100/318 (31%), Gaps = 86/318 (27%) Query: 72 QAKLCDSGELV--------------AIKKVLQD--KRFKNRELQIMRKLDHCNIVRLRYF 115 +A ++GE AIK++ ++ + R ++ ++ V LR+ Sbjct: 91 EATDQETGESFEVHVPYFTERPPSNAIKQMKEEVLRLRLLRGIKNQKQAK----VHLRFI 146 Query: 116 FYSSGEKKDE-------------------VYLNLVLDYVPETVYRVARHYSRAKQTLPVI 156 F K + +L + +T V +S ++L Sbjct: 147 FPFDLVKDPQKKKMIRVRLDERDMWVLSRFFLYPRMQSNLQTFGEVLLSHSSTHKSLVHH 206 Query: 157 YVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSY 216 Q+ R LA +H +G+ H ++P +++LD V L F + LVR V Sbjct: 207 ARLQLTLQVIRLLASLHHYGLVHTYLRPVDIVLDQRGGVF-LTGF---EHLVRDGARVVS 262 Query: 217 ICSRYYRAPELIF----------GATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQL 266 SR + PEL T T S D W+ G V+ + Sbjct: 263 SVSRGFEPPELEARRATISYHRDRRTLMTFSFDAWALGLVIYWIWCADLP---------- 312 Query: 267 VEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPT 326 I K E W P AL L Y Sbjct: 313 --ITKDAALGGSE---------------------WIFRSCKNIPQPVRALLEGFLRYPKE 349 Query: 327 ARLTPLEACAHSFFDELR 344 RL PL+A +++LR Sbjct: 350 DRLLPLQAMETPEYEQLR 367 >2RSV-A nrPDB Length = 403 Score = 75.1 bits (183), Expect = 6e-14, Method: Composition-based stats. Identities = 45/246 (18%), Positives = 84/246 (34%), Gaps = 37/246 (15%) Query: 45 GQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELV------AIKKVLQDKRFKNREL 98 G+ + + IG G FG +Y A +S E V +K D EL Sbjct: 33 GEIITDMAKKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTEL 91 Query: 99 QIM---------------RKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVA 143 + RKL + + + +K + Y +++D + ++ Sbjct: 92 KFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLH--DKNGKSYRFMIMDRFGSDLQKI- 148 Query: 144 RHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLD-PDTAVLKLCDFG 202 Y + V ++ L YIH H DIK NLLL+ + + L D+G Sbjct: 149 --YEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYG 206 Query: 203 SA--------KQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQ 254 A + + +P + + + + + G + D+ G + + L G Sbjct: 207 LAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAP-SRRGDLEILGYCMIQWLTGH 265 Query: 255 PIFPGD 260 + + Sbjct: 266 LPWEDN 271 >2LAV-A nrPDB Length = 361 Score = 74.7 bits (182), Expect = 7e-14, Method: Composition-based stats. Identities = 45/246 (18%), Positives = 84/246 (34%), Gaps = 37/246 (15%) Query: 45 GQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELV------AIKKVLQDKRFKNREL 98 G+ + + IG G FG +Y A +S E V +K D EL Sbjct: 26 GEIITDMAKKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTEL 84 Query: 99 QIM---------------RKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVA 143 + RKL + + + +K + Y +++D + ++ Sbjct: 85 KFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLH--DKNGKSYRFMIMDRFGSDLQKI- 141 Query: 144 RHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLD-PDTAVLKLCDFG 202 Y + V ++ L YIH H DIK NLLL+ + + L D+G Sbjct: 142 --YEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYG 199 Query: 203 SA--------KQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQ 254 A + + +P + + + + + G + D+ G + + L G Sbjct: 200 LAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAP-SRRGDLEILGYCMIQWLTGH 258 Query: 255 PIFPGD 260 + + Sbjct: 259 LPWEDN 264 >5DMZ-A nrPDB Length = 365 Score = 73.1 bits (178), Expect = 2e-13, Method: Composition-based stats. Identities = 49/292 (16%), Positives = 99/292 (33%), Gaps = 42/292 (14%) Query: 61 VIGNGSFGVVYQAK-----LCDSGELVAIKKVLQDKRFKNREL----QIMRKLDHCNIVR 111 ++G G+F VY+A + + +K K E Q+M +L ++ Sbjct: 72 LLGEGAFAQVYEATQGDLNDAKNKQKFVLKV---QKPANPWEFYIGTQLMERLK-PSMQH 127 Query: 112 LRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAY 171 + FYS+ ++ L L + + + + ++ +P V + ++ + Sbjct: 128 MFMKFYSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEKVMPQGLVISFAMRMLYMIEQ 187 Query: 172 IHSFGICHRDIKPQNLLL----------DPDTAVLKLCDFGSA---KQLVRGEPNVSYIC 218 +H I H DIKP N +L D +A L L D G + K +G + Sbjct: 188 VHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMKLFPKGTIFTAKCE 247 Query: 219 SRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTR 278 + ++ E++ + ID + + +L G +++ G Sbjct: 248 TSGFQCVEMLSN-KPWNYQIDYFGVAATVYCMLFG-----------TYMKVKNEGGECKP 295 Query: 279 EQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLT 330 E + P+ H + P + L + L+ T Sbjct: 296 EGLFRRLPH---LDMWNEFFHVMLNIPDCHHLPS-LDLLRQKLKKVFQQHYT 343 >3DZO-A nrPDB Length = 413 Score = 70.4 bits (171), Expect = 1e-12, Method: Composition-based stats. Identities = 58/317 (18%), Positives = 99/317 (31%), Gaps = 85/317 (26%) Query: 72 QAKLCDSGELV--------------AIKKVLQD--KRFKNRELQIMRKLDHCNIVRLRYF 115 +A ++GE AIK++ ++ + R ++ ++ V LR+ Sbjct: 96 EATDQETGESFEVHVPYFTERPPSNAIKQMKEEVLRLRLLRGIKNQKQAK----VHLRFI 151 Query: 116 FYSSGEKKDE-------------------VYLNLVLDYVPETVYRVARHYSRAKQTLPVI 156 F K + +L + +T V +S ++L Sbjct: 152 FPFDLVKDPQKKKMIRVRLDERDMWVLSRFFLYPRMQSNLQTFGEVLLSHSSTHKSLVHH 211 Query: 157 YVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSY 216 Q+ R LA +H +G+ H ++P +++LD V L F + LVR + Sbjct: 212 ARLQLTLQVIRLLASLHHYGLVHTYLRPVDIVLDQRGGVF-LTGF---EHLVRDGASAVS 267 Query: 217 ICSRYYRAPE------LIFGATD---YTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLV 267 R + PE L FG T + D W+ G + Sbjct: 268 PIGRGFAPPETTAERMLPFGQHHPTLMTFAFDTWTLGLAIY------------------- 308 Query: 268 EIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTA 327 I P + + W P AL L Y Sbjct: 309 -WIWCADLPNTDDA-------------ALGGSEWIFRSCKNIPQPVRALLEGFLRYPKED 354 Query: 328 RLTPLEACAHSFFDELR 344 RL PL+A +++LR Sbjct: 355 RLLPLQAMETPEYEQLR 371 >6EWX-A nrPDB Length = 484 Score = 67.7 bits (164), Expect = 1e-11, Method: Composition-based stats. Identities = 48/237 (20%), Positives = 71/237 (29%), Gaps = 69/237 (29%) Query: 138 TVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLL-------- 189 R + RA+ + V + QL L ++ GI HRD+ +NLLL Sbjct: 192 DFVRDSVASHRAEPEVYERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLVHCNPQSS 251 Query: 190 --------------------------------DPDTAVLKLCDFGSAKQLVRGEPNVSYI 217 + L + +F AKQ G N+ Sbjct: 252 PGPSANPSVPTTTSRCPSAAPAATTACQGGPGEKHLPRLIISNFLKAKQKPGGTTNLQQK 311 Query: 218 CSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPT 277 S+ APE++ + D + G ++ ELL F Sbjct: 312 KSQARLAPEIVSASQY--RKFDEFQTGILIYELLHQPNPFE------------------V 351 Query: 278 REQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEA 334 R Q+RE + Y P + P L LLE P R+ EA Sbjct: 352 RAQLRERD--YRREDLPPLPTLSL-------YSPGLQQLAHLLLEADPIKRIRIGEA 399 >4OAU-C nrPDB Length = 699 Score = 67.4 bits (163), Expect = 1e-11, Method: Composition-based stats. Identities = 47/279 (16%), Positives = 84/279 (30%), Gaps = 71/279 (25%) Query: 79 GELVAIKKVLQDKRFKNRELQIM---RKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYV 135 + VA+K + RE+ + R+ H FY S + +++ + L Sbjct: 366 KQEVAVKTFCEGSPRAQREVSCLQSSRENSH------LVTFYGSESHRGHLFVCVTL--C 417 Query: 136 PETVYRVAR-HYSRAKQTLPVIYVKLYMYQLFRSLAYIH-SFGICHRDIKPQNLLLDPDT 193 +T+ H + + + + +F+++ +H S G H+D++PQN+L+D Sbjct: 418 EQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKK 477 Query: 194 AVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLG 253 A L DF + ++ + E+ D VL + G Sbjct: 478 AA-HLADF---------DKSIKWAGDPQ----EVKRDLEDLGR--------LVLYVVKKG 515 Query: 254 QPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEA 313 F +KA +V + E Sbjct: 516 SISFE------------------------------------DLKAQSNEEVVQLSPDEET 539 Query: 314 IALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPN 352 L RL R + H FF L N Sbjct: 540 KDLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRN 578 >5VE6-A nrPDB Length = 492 Score = 64.3 bits (155), Expect = 1e-10, Method: Composition-based stats. Identities = 48/230 (20%), Positives = 69/230 (30%), Gaps = 79/230 (34%) Query: 155 VIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLL------------------------- 189 V + QL L ++ GI HRD+ +NLLL Sbjct: 207 ERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLVHCTLQAGPGPAPAPAPAPAAAAPP 266 Query: 190 -------------------DPDTAVLK------LCDFGSAKQLVRGEPNVSYICSRYYRA 224 P+ K + +F AKQ G PN+ S+ A Sbjct: 267 CSSAAPPAGGTLSPAAGPASPEGPREKQLPRLIISNFLKAKQKPGGTPNLQQKKSQARLA 326 Query: 225 PELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREM 284 PE++ + D + G ++ ELL F R Q+RE Sbjct: 327 PEIVSASQY--RKFDEFQTGILIYELLHQPNPFE------------------VRAQLRER 366 Query: 285 NPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEA 334 + Y + P + A P L LLE P R+ EA Sbjct: 367 D--YRQEDLPPLPALSL-------YSPGLQQLAHLLLEADPIKRIRIGEA 407 >2W1Z-A nrPDB Length = 368 Score = 62.4 bits (150), Expect = 4e-10, Method: Composition-based stats. Identities = 45/227 (19%), Positives = 72/227 (31%), Gaps = 46/227 (20%) Query: 127 YLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQN 186 +L + + V +S ++L QL R A + +G+ H D + +N Sbjct: 162 FLYPRMQSNLHILGDVLLSHSSTHKSLVHHARLQLTLQLIRLAASLQHYGLVHADFQVRN 221 Query: 187 LLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPE-----LIFGATDY----TSS 237 +LLD V L F + LVR + R + PE ++ + T Sbjct: 222 ILLDQRGGVF-LTGF---EHLVRDGASAVSPIGRGFAPPETTAERMLPYRQHHPTLMTFP 277 Query: 238 IDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIK 297 D W+ G + I P E ++ Sbjct: 278 FDTWTLGLAIY--------------------WIWCADLPNTEDA-------------ELG 304 Query: 298 AHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELR 344 W P AL L Y+ RL PL+A S +++LR Sbjct: 305 GIEWIYRRCKNIPQPVRALLEGFLRYSKEDRLLPLQAMETSEYEQLR 351 >6BHC-A nrPDB Length = 438 Score = 61.2 bits (147), Expect = 7e-10, Method: Composition-based stats. Identities = 52/290 (17%), Positives = 81/290 (27%), Gaps = 66/290 (22%) Query: 82 VAIKKVLQDKRFKNRELQIMRKLD----HCNI----------VRLRYFFYSSGEKKDEVY 127 A+K + + + H NI V R + KK + Sbjct: 86 YAVKICKSKAKESQQYYHSLAVRQSLAVHFNIQQDCGHFLAEVPNRLLPWEDPSKKQRSH 145 Query: 128 LNLVLDYVP----ETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIK 183 + ++ VP R + L V L + QL L ++ + + H D++ Sbjct: 146 VVVITREVPCLTVADFVRDSLAQHGKSPDLYERQVCLLLLQLCSGLEHLKPYHVTHCDLR 205 Query: 184 PQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY-------------------YRA 224 +NLLL FG A+ I S + A Sbjct: 206 LENLLLVHYQPGGTAQGFGPAEPTPTSSYPTRLIVSNFSQAKQKSHLVDPEILRDQSRLA 265 Query: 225 PELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREM 284 PE+I D + G ++ E+L F E Sbjct: 266 PEIITATQY--KKCDEFQTGILIYEMLHLPNPFD--------------------ENPELK 303 Query: 285 NPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEA 334 YT P+I FR L S LL P+ R+ +A Sbjct: 304 EREYTRADLPRIP-------FRSPYSRGLQQLASCLLNPNPSERILISDA 346 >2JII-A nrPDB Length = 352 Score = 59.3 bits (142), Expect = 3e-09, Method: Composition-based stats. Identities = 29/166 (17%), Positives = 61/166 (36%), Gaps = 14/166 (8%) Query: 124 DEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIK 183 + Y LVL + ++ K L V +L +L ++H H ++ Sbjct: 129 QDKYRFLVLPSLGRSLQSALD--VSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVT 186 Query: 184 PQNLLLD-PDTAVLKLCDFGSAKQLVRGEPNVSYI--------CSRYYRAPELIFGATDY 234 +N+ +D D + + L +G A + +V+Y+ + + +L G Sbjct: 187 AENIFVDPEDQSQVTLAGYGFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMDLHKGCGP- 245 Query: 235 TSSIDVWSAGCVLAELLLGQPIFPG--DSGVDQLVEIIKVLGTPTR 278 + D+ S G + + L G + + D + + K + P Sbjct: 246 SRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGP 291 >6EAS-A nrPDB Length = 308 Score = 56.2 bits (134), Expect = 3e-08, Method: Composition-based stats. Identities = 42/276 (15%), Positives = 84/276 (30%), Gaps = 48/276 (17%) Query: 71 YQAKLCDSGELVAI--------KKVLQDKRFKNRE-LQIMRKLDHCNIVRLRYFFYSSGE 121 Y+ L SG +A+ K ++ + R+ + + K+ H N + L + E Sbjct: 57 YKGTL-SSGVEIAVASSLVTSAKDWSKENESQYRKKITNLSKVSHKNFMNLLGYC----E 111 Query: 122 KKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGI--CH 179 ++ +V +Y P + R + L + + L ++H Sbjct: 112 EEHPFTRVMVFEYAPNGTL-FEHLHVREAEKLDWMARLRISMGIAYCLEHMHQLQTPAAL 170 Query: 180 RDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSID 239 R+ + L D A K+ D + + + S + +P++ Y Sbjct: 171 RNFDSTTVYLTDDFAA-KVSDL---EFWNDAKGHNSTTNNELAFSPDMEDIVRKY----- 221 Query: 240 VWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH 299 G VL E+L G+ + + Y E + Sbjct: 222 ----GMVLLEILTGRVP-----------------SSEDDGPLENWVSRYFEGGMRLEELI 260 Query: 300 PWTKVFRPRTPPEAI-ALCSRLLEYTPTARLTPLEA 334 + F P A+ + ++ P R E Sbjct: 261 DPSIGFFPEDTARALCEVVRSCIDRDPKKRPQMKEV 296 >4CYJ-A nrPDB Length = 438 Score = 56.2 bits (134), Expect = 3e-08, Method: Composition-based stats. Identities = 33/160 (20%), Positives = 65/160 (40%), Gaps = 27/160 (16%) Query: 67 FGV---VYQAKLCDSGELVAIKKVLQDKRFKNRELQIM------RKLDHCNIVRLRYFFY 117 FG VY+A+ +G A++++ + R N E I+ +K+ + +IV + F Sbjct: 65 FGYPSWVYKAQNSRNGRHYALRRL-EGYRLTN-EKAILNVMKDWKKIKNASIVTIHEVFT 122 Query: 118 SSGEKKDEVYLNLVLDYVPETVYRVARHYS-------RAKQTLPVIYVKLYMYQLFRSLA 170 + + + L D+ P + H+ R +P + Y+ Q+ +L Sbjct: 123 TR--EFGDSSLIFAYDFHPLSKTLQEHHFQPIHGNRYRPPPAVPENTIWGYICQIANALK 180 Query: 171 YIHSFGICHRDIKPQNLLLDP----DTAVLKLCD---FGS 203 IHS + R ++P ++L + + D FG Sbjct: 181 TIHSNRLAARCLEPSKIILTDINRIRLSACAILDVVQFGM 220 >6M7Z-A nrPDB Length = 319 Score = 55.4 bits (132), Expect = 5e-08, Method: Composition-based stats. Identities = 52/338 (15%), Positives = 106/338 (31%), Gaps = 80/338 (23%) Query: 58 DTKVIGNGSFGVVYQAKLCDSGELVAIK-----KVLQDKRFKNRE-----LQIMRKLDHC 107 K + +GSF + + V + ++L + RE ++++ LD Sbjct: 34 ILKRLLSGSF----LRRDGSTTVNVRVPARELVRLLSLTPEQQREGVSAKVRLINLLDPK 89 Query: 108 NIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRA------KQTLPVIYVKLY 161 V Y + K+ + L + +Y + + S+ + V++ Sbjct: 90 YSVYEPYLYREILPKRSPLLLPSLGEYRGAFLTYIFHPLSKGLVGDMLETGRSHPDVQVL 149 Query: 162 MYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY 221 + +L +H+ G+ HR I+ + + PD V+ L G G ++ + Sbjct: 150 AANMVAALKSLHNLGLLHRSIELNSFSVLPDGTVV-LG--GLDTAAPIGTETRLWVG--F 204 Query: 222 Y---RAPEL--------IFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEII 270 + APE+ +T DV+S G ++ Sbjct: 205 FGQETAPEIDRNFLADLALTQGRHTVKSDVYSLGV-------------------AFRNLV 245 Query: 271 KVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIA-LCSRLLEYTPTARL 329 ++LG P + + E + L +++E P R Sbjct: 246 QLLGNGN--------------------LGPEDRGAVRQDHLELLDKLSQKMIEEEPGNRP 285 Query: 330 TPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQEL 367 T E F+ L +++ R F + L Sbjct: 286 TIEEIMKDPLFEGLNFEDIEEGKARP----FRYKQNRL 319 >5GZ9-A nrPDB Length = 305 Score = 53.5 bits (127), Expect = 2e-07, Method: Composition-based stats. Identities = 35/212 (16%), Positives = 71/212 (33%), Gaps = 37/212 (17%) Query: 57 TDTKVIGNGSFGVVYQAKLCDSGELVAIKKV--LQDKRFKNRELQIMRKLDHCNIVRLRY 114 K +G G+ V+ ++ + VA+ ++ L+ K LQ+++ L ++V L Sbjct: 37 RQLKRVGEGAVKRVFLSEWKE--HKVALSRLTRLEMKEDFLHGLQMLKSLQSEHVVTLVG 94 Query: 115 FFYSSGEKKDEVYLNLVLDYVPETVYRVARH---YSRAKQTLPVIYVKLYMYQLFRSLAY 171 + G ++ +Y P S+ + + + + Y Sbjct: 95 YCEEDGT--------ILTEYHPLGSLSNLEETLQLSKYQDVNTWQHRLQLAMEYVSIINY 146 Query: 172 IHSFGICHRDIKPQNLLLDPDTAVLKLCDFGS------AKQLVRGEPNVSYICSRY---- 221 +H + R + N L + L +F A LV + V C Sbjct: 147 LHHSPLGTRVMCDSNDLPKTLSQYLLTSNFSIVANDLDALPLVDHDSGVLIKCGHRELHG 206 Query: 222 -YRAPELIFGATD-----------YTSSIDVW 241 + APE ++ + Y +D+W Sbjct: 207 DFVAPEQLWPYGEDTPFQDDLMPSYNEKVDIW 238 >5GZA-A nrPDB Length = 290 Score = 53.5 bits (127), Expect = 2e-07, Method: Composition-based stats. Identities = 40/220 (18%), Positives = 65/220 (29%), Gaps = 54/220 (24%) Query: 57 TDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRE---LQIMRKLDHCNIVRLR 113 K+IG G+ VY ++ G+ VA+ VL ++ + L ++R L ++V L Sbjct: 28 RRVKLIGQGAVKKVYLSEWQ--GQKVAL-SVLSSDQYADDFLHGLSMLRALQSSHVVTLV 84 Query: 114 YFFYSSGEKKDEVYLNLVLDYVPET---VYRVARHYSRAKQTLPVIYVKLYMYQLFRSLA 170 V +Y P R + LA Sbjct: 85 GVCEEDA--------VFVTEYHPLGSVLTLDTTLAQERYRWRNSWHTRLQLAIDYVAFLA 136 Query: 171 YIHS--FGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQL------VRGEPNVSYIC---- 218 Y+HS GI R ++ D + L F A + + P V Sbjct: 137 YLHSSPAGI--R------VMCDSNDLHKTLSQFLLASDMRLLANDLDALPEVEKGGLGVK 188 Query: 219 ------SRYYRAPELI-----------FGATDYTSSIDVW 241 + + APE + Y D+W Sbjct: 189 CGHHELTGDFVAPEQLWPYGEDFSFSDEAMPGYDEKTDIW 228 >4BWP-A nrPDB Length = 448 Score = 48.9 bits (115), Expect = 4e-06, Method: Composition-based stats. Identities = 29/154 (18%), Positives = 58/154 (37%), Gaps = 33/154 (21%) Query: 71 YQAKLCDSGELVAIKKV---LQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVY 127 Y+A +G ++++ +++ +KL H N+V+LR F + + Sbjct: 67 YRATHNTTGYKYCLRRIHGFRLQSTKCMTLVEMWKKLQHTNVVQLREVFTTKAFGDNS-- 124 Query: 128 LNLVLDYVPETVYRVARHYSRAKQT----------------------------LPVIYVK 159 L LV DY P + +A++++ A +T LP + Sbjct: 125 LVLVYDYHPGSQTLLAKYFTPAPETNGYTDPFQGEARPFSHKSNMQRTSNGPLLPEATIW 184 Query: 160 LYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDT 193 + QL L IH G+ + + P +++ Sbjct: 185 SIIMQLTAGLKAIHHAGLACKVLDPTKIIVTGKR 218 >4AZW-A nrPDB Length = 471 Score = 48.9 bits (115), Expect = 4e-06, Method: Composition-based stats. Identities = 25/119 (21%), Positives = 47/119 (39%), Gaps = 20/119 (16%) Query: 89 QDKRFKNRELQIMRK----LDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVAR 144 ++K + E++ + + D + GE + LV++ +P + Sbjct: 283 RNKHELHNEIKFLTQPPAGFDAP-------AVLAHGENAQSGW--LVMEKLPGRLLSDML 333 Query: 145 HYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGS 203 I + + L RSLA + G H D++P N+++D +L DFGS Sbjct: 334 AAGE------EIDREKILGSLLRSLAALEKKGFWHDDVRPWNVMVDARQHA-RLIDFGS 385 >4AZV-A nrPDB Length = 569 Score = 48.5 bits (114), Expect = 5e-06, Method: Composition-based stats. Identities = 20/75 (26%), Positives = 33/75 (44%), Gaps = 7/75 (9%) Query: 129 NLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLL 188 LV++ +P + I + + L RSLA + G H D++P N++ Sbjct: 318 WLVMEKLPGRLLSDMLAAGE------EIDREKILGSLLRSLAALEKQGFWHDDVRPWNVM 371 Query: 189 LDPDTAVLKLCDFGS 203 +D +L DFGS Sbjct: 372 VDARQHA-RLIDFGS 385 >6G38-A nrPDB Length = 357 Score = 47.7 bits (112), Expect = 9e-06, Method: Composition-based stats. Identities = 30/179 (16%), Positives = 60/179 (33%), Gaps = 56/179 (31%) Query: 57 TDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQD------------------KRFKNREL 98 + IG G FG V+ + VAIK + + + ++EL Sbjct: 44 QRCEKIGEGVFGEVF--QTIADHTPVAIKIIAIEGPDLVNGSHQKTFEEILPEIIISKEL 101 Query: 99 QIMRK-----------LDHCNIVR-------LRYFFY-----------SSGEKKDEVYLN 129 ++ L+ + V+ L+ + + K D++++ Sbjct: 102 SLLSGEVCNRTEGFIGLNSVHCVQGSYPPLLLKAWDHYNSTKGSANDRPDFFKDDQLFIV 161 Query: 130 LVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIH-SFGICHRDIKPQNL 187 L ++ + ++ S + K ++QL SLA S HRD+ N+ Sbjct: 162 LEFEFGGIDLEQMRTKLS------SLATAKSILHQLTASLAVAEASLRFEHRDLHWGNV 214 >4WWA-A nrPDB Length = 261 Score = 47.7 bits (112), Expect = 1e-05, Method: Composition-based stats. Identities = 28/149 (18%), Positives = 56/149 (37%), Gaps = 17/149 (11%) Query: 71 YQAKLCDSGELVAIKKVLQDKRFKNRELQI----MRKLDHCNIV-RLR---YFFYSSGEK 122 Y + DS + IK KR+++ ++ R L+ ++ +L Sbjct: 38 YLPRAKDSHQKYIIKY-RPPKRYRHPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIA 96 Query: 123 KDEVYLNLVLDYVPETV-----YRVARHYSRAKQTLPVIY-VKLYMYQLFRSLAYIHSFG 176 D + L+++ E + + +++ P V + ++ R + +H Sbjct: 97 CDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWND 156 Query: 177 ICHRDIKPQNLLLDPDTAV--LKLCDFGS 203 CH D+ N++L D A L DFG Sbjct: 157 YCHGDLTSSNIVLVRDGARWTPHLIDFGL 185 >3Q60-A nrPDB Length = 371 Score = 47.7 bits (112), Expect = 1e-05, Method: Composition-based stats. Identities = 39/211 (18%), Positives = 66/211 (31%), Gaps = 24/211 (11%) Query: 137 ETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVL 196 E ++ + ++ + + QL R A + S G+ H P NL + PD L Sbjct: 175 ELLFSTLDFVYVFRGDEGILALHILTAQLIRLAANLQSKGLVHGHFTPDNLFIMPDG-RL 233 Query: 197 KLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATD-YTSSIDVWSAGCVLAELLLGQP 255 L D + G + Y E + +T +T +++ W G + + Sbjct: 234 MLGD--VSALWKVGTRGPASSVPVTYAPREFLNASTATFTHALNAWQLGLSIYRVWCLFL 291 Query: 256 IFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIA 315 F L TP + ++ P Sbjct: 292 PF--------------GLVTPG------IKGSWKRPSLRVPGTDSLAFGSCTPLPDFVKT 331 Query: 316 LCSRLLEYTPTARLTPLEACAHSFFDELRDP 346 L R L + RL PLEA F +L++ Sbjct: 332 LIGRFLNFDRRRRLLPLEAMETPEFLQLQNE 362 >3ENH-A nrPDB Length = 540 Score = 47.7 bits (112), Expect = 1e-05, Method: Composition-based stats. Identities = 27/113 (23%), Positives = 39/113 (34%), Gaps = 13/113 (11%) Query: 111 RLRYFFYSSGEKKDEVYLNLVLDY---------VPETVYRVARHYSRAKQTLPVIY-VKL 160 RL S ++ YL LV D+ V R+ Y K VI Sbjct: 376 RLDENIRKSRTAREARYLALVKDFGIPAPYIFDVDLDNKRIMMSYINGKLAKDVIEDNLD 435 Query: 161 YMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPN 213 Y++ + +H + H D+ N + D D L + DFG K E Sbjct: 436 IAYKIGEIVGKLHKNDVIHNDLTTSNFIFDKD---LYIIDFGLGKISNLDEDK 485 >4CZY-B nrPDB Length = 429 Score = 45.8 bits (107), Expect = 3e-05, Method: Composition-based stats. Identities = 29/143 (20%), Positives = 63/143 (44%), Gaps = 20/143 (13%) Query: 71 YQAKLCDSGELVAIKKVLQDKRFKNRELQIM------RKLDHCNIVRLRYFFYSSGEKKD 124 Y+A+ +G A++++ + R N E I+ +K+ + NIV + F + E Sbjct: 61 YKAQNNKNGRHFALRRI-EGYRLTN-EKAILNVTKEWKKIINANIVTVHEAFTT--EFFG 116 Query: 125 EVYLNLVLDY--VPETVYR------VARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFG 176 + L V D+ + ET+Y + + R +P + Y+ Q+ +L IH+ Sbjct: 117 DSSLIFVYDFHPLSETLYDHHFPPNNSHNRLRNTNKIPENLLWSYVCQIANALLAIHNAK 176 Query: 177 ICHRDIKPQNLLLDPDTAVLKLC 199 + R ++ ++ + ++L Sbjct: 177 LAARCLELSKII--WENNRIRLA 197 >1TQM-A nrPDB Length = 282 Score = 41.2 bits (95), Expect = 8e-04, Method: Composition-based stats. Identities = 35/188 (18%), Positives = 67/188 (35%), Gaps = 36/188 (19%) Query: 58 DTKVIGNGSFGVVYQAKLCDSGELVAI---------KKVLQDKRFKNRELQIMRKLDHCN 108 K++G G V+ GE V KKV + + + + ++ N Sbjct: 94 IGKLMGEGKESAVFNCYSEKFGECVVKFHKVGHTSFKKVKEKRDYGDLHFSVLAIRSARN 153 Query: 109 IVRLRYFFYSSGEKKDEVYLN----LVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQ 164 R G +VY ++++ + A+ R + P + + + + Sbjct: 154 --EFRALQKLQGLAVPKVYAWEGNAVLMELID------AKELYRVRVENPDEVLDMILEE 205 Query: 165 LFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDF---------GSAKQLVRGEPNVS 215 + + + H GI H D+ N+L+ + + + DF G + L R N+ Sbjct: 206 VAK---FYH-RGIVHGDLSQYNVLVSEEG--IWIIDFPQSVEVGEEGWREILERDVRNII 259 Query: 216 YICSRYYR 223 SR YR Sbjct: 260 TYFSRTYR 267 >5YK0-A nrPDB Length = 452 Score = 38.9 bits (89), Expect = 0.004, Method: Composition-based stats. Identities = 35/191 (18%), Positives = 63/191 (32%), Gaps = 61/191 (31%) Query: 68 GVVYQAKLCDSGELVAIKK--------VLQDKRFKNRELQIMRKL--------------- 104 G V++A D G VA+K + D + R + ++++L Sbjct: 146 GQVHKAIWSD-GREVAVKIQYPGADEALRADLKTMQRMVGVLKQLSPGADVQGVVDELVE 204 Query: 105 -----------------------DHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYR 141 DH R+ +V + ++ VP + Sbjct: 205 RTEMELDYRLEAANQRAFAKAYHDHP-----RFQVPHVVASAPKVVIQEWIEGVP--MAE 257 Query: 142 VARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDF 201 + RH + ++ L + + R L G+ H D P N +L PD + + DF Sbjct: 258 IIRHGTTEQRDLIGTLLAELTFDAPRRL------GLMHGDAHPGNFMLLPD-GRMGIIDF 310 Query: 202 GSAKQLVRGEP 212 G+ + G P Sbjct: 311 GAVAPMPGGFP 321 >6FAI-l nrPDB Length = 425 Score = 37.7 bits (86), Expect = 0.010, Method: Composition-based stats. Identities = 26/197 (13%), Positives = 56/197 (28%), Gaps = 50/197 (25%) Query: 52 QEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKK------------------------- 86 ++ Y+ IG G +Y+ + V +K Sbjct: 91 RDTVYSVGNTIGVGKESDIYKVSDKNGNPRV-MKIHRLGRTSFHSVRNNRDYLKKSNQGA 149 Query: 87 --VLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVAR 144 + + N+E Q M L + E D +V++ + R R Sbjct: 150 NWMHLSRLAANKEYQFMSM--------LYSKGFKVPEPFDNSRHIVVMELIEGYPMRRLR 201 Query: 145 HYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLL-----DPDTAVLKLC 199 + + + ++ L S G+ H D N+++ D + + Sbjct: 202 KHKNIPKLYS--DLMCFIVDLANS-------GLIHCDFNEFNIMIKDKLEDENDCGFVVI 252 Query: 200 DFGSAKQLVRGEPNVSY 216 DF + + + + Sbjct: 253 DFPQCISIQHQDADYYF 269 >4BVU-A nrPDB Length = 211 Score = 36.9 bits (84), Expect = 0.018, Method: Composition-based stats. Identities = 26/145 (17%), Positives = 51/145 (35%), Gaps = 16/145 (11%) Query: 58 DTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFY 117 K+IG GS +++ + + K L ++ E+ M + L FY Sbjct: 44 LGKLIGQGSTAEIFE--DVNDSSALYKKYDLIGNQY--NEILEMAWQESE----LFNAFY 95 Query: 118 SSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQL-FRSLAYIHSFG 176 +V+ Y + R+ R + + + L + + ++ Sbjct: 96 GDEAS-------VVIQYGGDVYLRMLRVPGTPLSDIDTADIPDNIESLYLQLICKLNELS 148 Query: 177 ICHRDIKPQNLLLDPDTAVLKLCDF 201 I H D+ N+L D ++ L DF Sbjct: 149 IIHYDLNTGNMLYDKESESLFPIDF 173 >5I35-A nrPDB Length = 393 Score = 34.6 bits (78), Expect = 0.083, Method: Composition-based stats. Identities = 32/211 (15%), Positives = 56/211 (26%), Gaps = 61/211 (28%) Query: 47 GPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKK-------------------- 86 GP+ ++ Y + + S G V+ A++ G VA+K Sbjct: 67 GPNWRDKLEYFEERPFAAASIGQVHLARMK-GGREVAMKIQYPGVAQSINSDVNNLMAVL 125 Query: 87 ------------------VLQDKRFK---NRELQIMRKLD-----HCNIVRLRYFFYSSG 120 + ++ + RE RK H +F+ Sbjct: 126 NMSNMLPEGLFPEHLIDVLRRELALECDYQREAACARKFRDLLKGHP------FFYVPEI 179 Query: 121 EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLF-RSLAYIHSFGICH 179 + L + V + L Y + L + F Sbjct: 180 VDELCSPHVLTTELVSG-------FPLDQAEGLSQEIRNEICYNILVLCLRELFEFHFMQ 232 Query: 180 RDIKPQNLLLDPDTAVLKLCDFGSAKQLVRG 210 D N DP + L DFG+ ++ R Sbjct: 233 TDPNWSNFFYDPQQHKVALLDFGATREYDRS 263 >6EF6-A nrPDB Length = 354 Score = 34.2 bits (77), Expect = 0.094, Method: Composition-based stats. Identities = 13/56 (23%), Positives = 23/56 (41%), Gaps = 14/56 (25%) Query: 174 SFGICHRDIKPQNLLLDPDTAVLKLC--------------DFGSAKQLVRGEPNVS 215 +G+ H D++ NLL+D T + DFG+A + +P + Sbjct: 224 RYGLIHADLRLANLLVDSSTPQRTITVIDFDDCGFGWYFYDFGTAVSFIEHDPRLG 279 >6DFL-A nrPDB Length = 259 Score = 32.7 bits (73), Expect = 0.33, Method: Composition-based stats. Identities = 29/137 (21%), Positives = 50/137 (36%), Gaps = 8/137 (5%) Query: 63 GNGSFGVVYQAKLCDSGELVAIKKVLQDKRF---KNRELQIMRKLDHCNIVRLRYFFY-S 118 G G F V + GE+ K +L K +E Q +R+L + + Y Sbjct: 45 GRGYF--VKIHRGIGWGEI--AKNLLTAKLPVLGARQEWQAIRRLHEAGVATMTAVAYGE 100 Query: 119 SGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGIC 178 G + +V + + TV ++ P + + + R + +H G+ Sbjct: 101 RGSDPARQHSFIVTEELAPTVDLEVFSQDWRERPPPPRLKRALVEAVARMVGDMHRAGVN 160 Query: 179 HRDIKPQNLLLDPDTAV 195 HRD + LL D V Sbjct: 161 HRDCYICHFLLHTDKPV 177 >3J4J-A nrPDB Length = 569 Score = 32.3 bits (72), Expect = 0.37, Method: Composition-based stats. Identities = 13/52 (25%), Positives = 25/52 (48%), Gaps = 4/52 (7%) Query: 51 PQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMR 102 +E Y + +V+G V +G+ VA V Q + +N E++++R Sbjct: 469 AREPQYKE-EVLGQ---AEVRAIFRLPTGKQVAGCMVTQGRIPRNAEVRVLR 516 >5U75-A nrPDB Length = 168 Score = 31.9 bits (71), Expect = 0.47, Method: Composition-based stats. Identities = 19/107 (17%), Positives = 42/107 (39%), Gaps = 10/107 (9%) Query: 72 QAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLV 131 + +G + K+ N+E+ +++LDH I+R + Y + N+V Sbjct: 67 EGTYTVAGRVYTPKR----NITLNKEVVTLKELDH--IIRFAHISYGLYMGEHLPKGNIV 120 Query: 132 LDYVPETVYRVARH----YSRAKQTLPVIYVKLYMYQLFRSLAYIHS 174 ++ Y + H +R + +K ++L +S+ I Sbjct: 121 INTKNGGKYTLESHKELQKNRENVEINTDDIKNVTFELVKSVNDIEQ 167 >1IOM-A nrPDB Length = 377 Score = 31.5 bits (70), Expect = 0.64, Method: Composition-based stats. Identities = 14/69 (20%), Positives = 35/69 (50%), Gaps = 2/69 (2%) Query: 36 KVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN 95 ++ + TP + + +E +++G G VY+A +G L + +++ +K + Sbjct: 228 RMIQEIGTPERAREWVREKLAKKERIMGMGH--RVYKAFDPRAGVLEKLARLVAEKHGHS 285 Query: 96 RELQIMRKL 104 +E QI++ + Sbjct: 286 KEYQILKIV 294 >5YZ0-C nrPDB Length = 791 Score = 31.5 bits (70), Expect = 0.76, Method: Composition-based stats. Identities = 17/88 (19%), Positives = 35/88 (39%), Gaps = 15/88 (17%) Query: 22 AFGSMKVSRDKDGSKVTTVVATPGQGPDR---PQEVSYTDTKVIGNGSFGVVYQAKLCDS 78 + VS D ++ ++ G +R P + ++ V QA+ + Sbjct: 75 PAAARDVSSDHKVHRLLDGMSKNPSGKNRETVPIKDNFEL----------EVLQAQYKEL 124 Query: 79 GELVAIKKVLQDKRFKNRELQIMRKLDH 106 E +K + ++ KN E++I+R H Sbjct: 125 KEK--MKVMEEEVLIKNGEIKILRDSLH 150 >4H05-A nrPDB Length = 273 Score = 30.8 bits (68), Expect = 1.0, Method: Composition-based stats. Identities = 13/27 (48%), Positives = 17/27 (62%), Gaps = 1/27 (3%) Query: 177 ICHRDIKPQNLLLDPDTAVLK-LCDFG 202 +CH D+ P N+LLDP T + L D G Sbjct: 186 VCHGDLCPDNVLLDPRTCEVTGLIDVG 212 >6G18-v nrPDB Length = 552 Score = 30.8 bits (68), Expect = 1.2, Method: Composition-based stats. Identities = 16/112 (14%), Positives = 33/112 (29%), Gaps = 18/112 (16%) Query: 90 DKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRA 149 + +E M+ L + + D +V++ + H Sbjct: 154 SRLSAMKEFAYMK--------ALYERKFPVPKPIDYNRHAVVMELINGYPLCQIHHVEDP 205 Query: 150 KQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDF 201 M + + + + G+ H D NL+LD + + DF Sbjct: 206 ASVYDEA-----MELIVK----LANHGLIHGDFNEFNLILDESDH-ITMIDF 247 >6FDN-A nrPDB Length = 320 Score = 30.4 bits (67), Expect = 1.6, Method: Composition-based stats. Identities = 16/112 (14%), Positives = 33/112 (29%), Gaps = 18/112 (16%) Query: 90 DKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRA 149 + +E M+ L + + D +V++ + H Sbjct: 154 SRLSAMKEFAYMK--------ALYERKFPVPKPIDYNRHAVVMELINGYPLCQIHHVEDP 205 Query: 150 KQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDF 201 M + + + + G+ H D NL+LD + + DF Sbjct: 206 ASVYDEA-----MELIVK----LANHGLIHGDFNEFNLILDESDH-ITMIDF 247 >1OR4-A nrPDB Length = 178 Score = 30.4 bits (67), Expect = 1.6, Method: Composition-based stats. Identities = 20/101 (19%), Positives = 43/101 (42%), Gaps = 10/101 (9%) Query: 78 SGELVAIKKVLQDKRFKNRELQIMRKLD---HCNIVRLRYFFYSSGEKKDEVYLNLVLDY 134 + + +KK L+ R + EL ++ +L NIV + FY + + + + +D Sbjct: 28 TNKHADVKKQLKMVRLGDAELYVLEQLQPLIQENIVNIVDAFYKNLDHESSL-----MDI 82 Query: 135 VPE--TVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIH 173 + + +V R+ + R Q + + + +A IH Sbjct: 83 INDHSSVDRLKQTLKRHIQEMFAGVIDDEFIEKRNRIASIH 123 >1WP9-A nrPDB Length = 494 Score = 30.0 bits (66), Expect = 1.8, Method: Composition-based stats. Identities = 17/73 (23%), Positives = 31/73 (42%), Gaps = 3/73 (4%) Query: 250 LLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRT 309 L++G PG + ++++E+I LG E E +P+ + + W +V P Sbjct: 158 LVIGLTASPGSTP-EKIMEVINNLGIEHIEYRSENSPDVRPYV--KGIRFEWVRVDLPEI 214 Query: 310 PPEAIALCSRLLE 322 E L +L Sbjct: 215 YKEVRKLLREMLR 227 >3G1Z-A nrPDB Length = 326 Score = 29.6 bits (65), Expect = 2.6, Method: Composition-based stats. Identities = 14/87 (16%), Positives = 27/87 (31%), Gaps = 3/87 (3%) Query: 253 GQPIFPGDSGVDQLVEIIKVLGTPTREQIRE-MNPNYTEFKFPQIKAHPWTKVFRP--RT 309 G ++ S + ++ P + R N P+ W + R Sbjct: 69 GINLYLMTSPEYHMKRLLAAGCGPVFQLCRSFRNEEMGRHHNPEFTMLEWYRPHYDMYRL 128 Query: 310 PPEAIALCSRLLEYTPTARLTPLEACA 336 E L ++L+ P L+ +A Sbjct: 129 MNEVDDLLQQVLDCQPAESLSYQQAFQ 155 >3CRC-A nrPDB Length = 265 Score = 29.2 bits (64), Expect = 3.1, Method: Composition-based stats. Identities = 7/33 (21%), Positives = 16/33 (48%) Query: 67 FGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQ 99 F V A+ + +A++K + + RE++ Sbjct: 201 FATVNLARHLGTKAEIALQKANEKFERRFREVE 233 >2Y0O-A nrPDB Length = 175 Score = 29.2 bits (64), Expect = 3.1, Method: Composition-based stats. Identities = 12/47 (25%), Positives = 22/47 (46%) Query: 183 KPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIF 229 K +L D + ++L D+G K+ G Y+ + Y + EL+ Sbjct: 14 KAGIVLTDEEVDQIQLMDYGLGKERKVGLQLFVYVNTDRYCSKELVL 60 >3NPK-A nrPDB Length = 291 Score = 29.2 bits (64), Expect = 3.4, Method: Composition-based stats. Identities = 9/50 (18%), Positives = 22/50 (44%), Gaps = 5/50 (10%) Query: 138 TVYRVARHYSRAKQTLPVI-----YVKLYMYQLFRSLAYIHSFGICHRDI 182 + + + RA+ L V+ + + +L +IH++ + H D+ Sbjct: 33 LMLKAGGKHFRAQLLLSVVQSNKPELLNQALDVALALEFIHTYSLIHDDL 82 >5IOL-A nrPDB Length = 150 Score = 28.8 bits (63), Expect = 4.4, Method: Composition-based stats. Identities = 13/55 (23%), Positives = 22/55 (40%), Gaps = 2/55 (3%) Query: 53 EVSYTDTKVIG--NGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLD 105 E ++ K G G G V Q +LVAIK + ++ + ++ L Sbjct: 3 ERTFIMVKPDGVQRGLVGEVIQRFERRGYKLVAIKMMHASEQLLQTHYEALKSLS 57 >5KKY-A nrPDB Length = 496 Score = 28.5 bits (62), Expect = 5.4, Method: Composition-based stats. Identities = 9/35 (25%), Positives = 19/35 (54%), Gaps = 2/35 (5%) Query: 46 QGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGE 80 P + E +Y + +GNG +G++Y+ + G+ Sbjct: 446 HNPIQKGEFAYNSLQELGNGEYGILYE--HTEKGQ 478 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.307 0.137 0.407 Lambda K H 0.267 0.0422 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 16,922,489 Number of Sequences: 36641 Number of extensions: 717417 Number of successful extensions: 6273 Number of sequences better than 10.0: 516 Number of HSP's better than 10.0 without gapping: 821 Number of HSP's successfully gapped in prelim test: 162 Number of HSP's that attempted gapping in prelim test: 2109 Number of HSP's gapped (non-prelim): 1193 length of query: 420 length of database: 10,336,785 effective HSP length: 100 effective length of query: 320 effective length of database: 6,672,685 effective search space: 2135259200 effective search space used: 2135259200 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.0 bits) S2: 60 (27.7 bits)