BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q9V3D4 (440 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 1JNE-A nrPDB 862 0.0 5Y29-A nrPDB 172 2e-43 4WKA-A nrPDB 150 9e-37 1WB0-A nrPDB 149 2e-36 2QF8-A nrPDB 146 2e-35 5XEP-A nrPDB 145 2e-35 5Y2C-A nrPDB 145 5e-35 1HJW-A nrPDB 139 3e-33 4P8U-A nrPDB 138 5e-33 5WUS-A nrPDB 138 6e-33 5WV8-A nrPDB 131 6e-31 3WKZ-A nrPDB 125 3e-29 3RM8-A nrPDB 125 3e-29 3W4R-A nrPDB 123 2e-28 1E9L-A nrPDB 110 2e-24 6G9C-A nrPDB 108 3e-24 6BT9-A nrPDB 102 3e-22 3QOK-A nrPDB 88 7e-18 6F8N-A nrPDB 83 3e-16 3WD0-A nrPDB 81 1e-15 5GZU-A nrPDB 81 1e-15 5GQB-A nrPDB 80 2e-15 4MNK-A nrPDB 77 2e-14 3ALF-A nrPDB 76 3e-14 1ITX-A nrPDB 72 4e-13 5ZL9-A nrPDB 72 5e-13 5Z7M-A nrPDB 71 7e-13 3AQU-A nrPDB 70 2e-12 4TXG-A nrPDB 69 3e-12 3CHF-A nrPDB 64 1e-10 4URI-A nrPDB 61 8e-10 4W5U-B nrPDB 57 1e-08 5DF0-A nrPDB 57 2e-08 3ARQ-A nrPDB 55 5e-08 1LL6-A nrPDB 52 7e-07 3G6L-A nrPDB 50 1e-06 6EPB-A nrPDB 50 2e-06 1KFW-A nrPDB 45 7e-05 5XWF-A nrPDB 41 0.001 5JH8-A nrPDB 40 0.002 3CZ8-A nrPDB 38 0.011 4DWS-C nrPDB 35 0.060 6OGD-C nrPDB 35 0.085 4WIW-A nrPDB 35 0.088 4TX8-A nrPDB 33 0.28 4S3J-A nrPDB 33 0.34 4S3K-A nrPDB 32 0.45 3N18-A nrPDB 31 1.0 1NAR-A nrPDB 30 1.5 3IAN-A nrPDB 30 1.9 4Q6T-A nrPDB 30 2.1 2BPA-1 nrPDB 30 2.8 3EBV-A nrPDB 30 3.1 5Z7H-A nrPDB 29 4.0 1GKM-A nrPDB 29 4.9 >1JNE-A nrPDB Length = 420 Score = 862 bits (2226), Expect = 0.0, Method: Compositional matrix adjust. Identities = 419/420 (99%), Positives = 420/420 (100%) Query: 21 ASNLVCYYDSSSYTREGLGKLLNPDLEIALQFCSHLVYGYAGLRGENLQAYSMNENLDIY 80 ASNLVCYYDSSSYTREGLGKLLNPDLEIALQFCSHLVYGYAGLRGENLQAYSMNENLDIY Sbjct: 1 ASNLVCYYDSSSYTREGLGKLLNPDLEIALQFCSHLVYGYAGLRGENLQAYSMNENLDIY 60 Query: 81 KHQFSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDLVK 140 KHQFSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAY+LVK Sbjct: 61 KHQFSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYELVK 120 Query: 141 TYGFDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTALVRDV 200 TYGFDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTALVRDV Sbjct: 121 TYGFDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTALVRDV 180 Query: 201 KDSLRADGFLLSLTVLPNVNSTWYFDIPALNGLVDFVNLATFDFLTPARNPEEADYSAPI 260 KDSLRADGFLLSLTVLPNVNSTWYFDIPALNGLVDFVNLATFDFLTPARNPEEADYSAPI Sbjct: 181 KDSLRADGFLLSLTVLPNVNSTWYFDIPALNGLVDFVNLATFDFLTPARNPEEADYSAPI 240 Query: 261 YHPDGSKDRLAHLNADFQVEYWLSQGFPSNKINLGVATYGNAWKLTKDSGLEGVPVVPET 320 YHPDGSKDRLAHLNADFQVEYWLSQGFPSNKINLGVATYGNAWKLTKDSGLEGVPVVPET Sbjct: 241 YHPDGSKDRLAHLNADFQVEYWLSQGFPSNKINLGVATYGNAWKLTKDSGLEGVPVVPET 300 Query: 321 SGPAPEGFQSQKPGLLSYAEICGKLSNPQNQFLKGNESPLRRVSDPTKRFGGIAYRPVDG 380 SGPAPEGFQSQKPGLLSYAEICGKLSNPQNQFLKGNESPLRRVSDPTKRFGGIAYRPVDG Sbjct: 301 SGPAPEGFQSQKPGLLSYAEICGKLSNPQNQFLKGNESPLRRVSDPTKRFGGIAYRPVDG 360 Query: 381 QITEGIWVSYDDPDSASNKAAYARVKNLGGVALFDLSYDDFRGQCSGDKYPILRAIKYRL 440 QITEGIWVSYDDPDSASNKAAYARVKNLGGVALFDLSYDDFRGQCSGDKYPILRAIKYRL Sbjct: 361 QITEGIWVSYDDPDSASNKAAYARVKNLGGVALFDLSYDDFRGQCSGDKYPILRAIKYRL 420 >5Y29-A nrPDB Length = 377 Score = 172 bits (437), Expect = 2e-43, Method: Compositional matrix adjust. Identities = 130/421 (30%), Positives = 217/421 (51%), Gaps = 61/421 (14%) Query: 24 LVCYYDSSSYTREGLGKLLNPDLEIALQFCSHLVYGYAGLRGENLQAYSMNENLDIYKHQ 83 LVCYY + S+ R G+GK D++ +L C+H+VYG+A L + L + ++ Y ++ Sbjct: 9 LVCYYTNWSWYRPGIGKYSPEDIDPSL--CTHIVYGFAVLGNDGLM--TAHDTWSDYDNR 64 Query: 84 FSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDLVKTYG 143 F E ++Y +KV L++GG +D D KY L+ R F++ A ++ YG Sbjct: 65 FYERVVEYKRY-GIKVSLALGGWNDSAGD---KYSKLVNDPAARA-KFVQHAVAFLEKYG 119 Query: 144 FDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTALVRDVKDS 203 FDGLDL +++PK W+ D P + K+ F LV ++ Sbjct: 120 FDGLDLDWEYPK------------CWQV-------DCSKGPDS--DKQGFADLVHELSAV 158 Query: 204 LRADGFLLSLTVLPN---VNSTWYFDIPALNGLVDFVNLATFDFLTPARNPEEADYSAPI 260 L+ G LLS V PN +++ +D+P L L+D++ + T+D+ + ++ + AP+ Sbjct: 159 LKPKGLLLSAAVSPNKMVIDAG--YDVPVLARLLDWIAVMTYDY--HGQWDKKTGHVAPL 214 Query: 261 Y-HPDGSKDRLAHLNADFQVEYWLSQGFPSNKINLGVATYGNAWKLTKDSGLEGVPVVPE 319 Y HPD D + NA++ + YW+ +G P++KI +G+ YG ++ + ++ G+ G+ + P Sbjct: 215 YYHPD---DDTTYFNANYTIHYWMEKGTPASKIVMGMPMYGQSFTI-ENRGIHGLNI-PV 269 Query: 320 TSGPAPEGFQSQKPGLLSYAEICGKLSNPQNQFLKGNESPLRRVSDPTKRFGGIAYRPVD 379 + G P G ++ G L+Y EIC ++ N S V DP +R G AY+ Sbjct: 270 SDGGEP-GEYTRAKGFLAYYEICDRIRN----------SGWTVVKDPYQRMGPYAYK--- 315 Query: 380 GQITEGIWVSYDDPDSASNKAAYARVKNLGGVALFDLSYDDFRGQCSGDKYPILRAIKYR 439 WVS+DD + K + + NLGG ++ L DD+R +C K+P+L AIK Sbjct: 316 ----GNQWVSFDDVEIIKKKVNFIKSLNLGGGMIWALDLDDYRNRCGQGKHPLLNAIKTE 371 Query: 440 L 440 L Sbjct: 372 L 372 >4WKA-A nrPDB Length = 377 Score = 150 bits (379), Expect = 9e-37, Method: Compositional matrix adjust. Identities = 121/431 (28%), Positives = 201/431 (46%), Gaps = 79/431 (18%) Query: 22 SNLVCYYDSSSYTREGLGKLLNPDLEIALQFCSHLVYGYAGLRGENLQAYSMNENLDIYK 81 + LVCY+ + + R+G + L DL+ +L C+HL+Y +AG+ L N+ + Sbjct: 1 AKLVCYFTNWAQYRQGEARFLPKDLDPSL--CTHLIYAFAGMTNHQLSTTEWND-----E 53 Query: 82 HQFSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDLVKT 141 + E LK+ P LK LL++GG + K+ D++ RQ F+ SA ++ Sbjct: 54 TLYQEFNGLKKMNPKLKTLLAIGGWNF----GTQKFTDMVATANNRQT-FVNSAIRFLRK 108 Query: 142 YGFDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTALVRDVK 201 Y FDGLDL +++P ++ A+ KE+FT LV+D+ Sbjct: 109 YSFDGLDLDWEYPGSQG--------------------------SPAVDKERFTTLVQDLA 142 Query: 202 DSLRADG-------FLLSLTVLPN---VNSTWYFDIPALNGLVDFVNLATFDFLTPARNP 251 ++ + + LLS V V++ + D A N +DFVNL +DF Sbjct: 143 NAFQQEAQTSGKERLLLSAAVPAGQTYVDAGYEVDKIAQN--LDFVNLMAYDF--HGSWE 198 Query: 252 EEADYSAPIYHPDGSKDRLAHLNADFQVEYWLSQGFPSNKINLGVATYGNAWKLTKDSGL 311 + +++P+Y A LN D V+ WL +G P++K+ LG+ TYG ++ L S Sbjct: 199 KVTGHNSPLYKRQEESGAAASLNVDAAVQQWLQKGTPASKLILGMPTYGRSFTLASSSDT 258 Query: 312 E-GVPVVPETSGPAPEGFQSQKPGLLSYAEICGKLSNPQNQFLKGNESPLRRVSDPTKRF 370 G P +G G +++ G+L+Y E+C KG + +R+ D Sbjct: 259 RVGAPA----TGSGTPGPFTKEGGMLAYYEVCS---------WKG--ATKQRIQDQK--- 300 Query: 371 GGIAYRPVDGQITEGIWVSYDDPDSASNKAAYARVKNLGGVALFDLSYDDFRG-QCSGDK 429 + Y D Q WV +DD +S K +Y + K LGG ++ L DDF G C+ + Sbjct: 301 --VPYIFRDNQ-----WVGFDDVESFKTKVSYLKQKGLGGAMVWALDLDDFAGFSCNQGR 353 Query: 430 YPILRAIKYRL 440 YP+++ ++ L Sbjct: 354 YPLIQTLRQEL 364 >1WB0-A nrPDB Length = 445 Score = 149 bits (377), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 123/431 (28%), Positives = 201/431 (46%), Gaps = 79/431 (18%) Query: 22 SNLVCYYDSSSYTREGLGKLLNPDLEIALQFCSHLVYGYAGLRGENLQAYSMNENLDIYK 81 + LVCY+ + + R+G + L DL+ +L C+HL+Y +AG+ L N+ + Sbjct: 1 AKLVCYFTNWAQYRQGEARFLPKDLDPSL--CTHLIYAFAGMTNHQLSTTEWND-----E 53 Query: 82 HQFSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDLVKT 141 + E LK+ P LK LL++GG + K+ D++ RQ F+ SA ++ Sbjct: 54 TLYQEFNGLKKMNPKLKTLLAIGGWNF----GTQKFTDMVATANNRQT-FVNSAIRFLRK 108 Query: 142 YGFDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTALVRDVK 201 Y FDGLDL +++P G G A+ KE+FT LV+D+ Sbjct: 109 YSFDGLDLDWEYP--------GSQG------------------SPAVDKERFTTLVQDLA 142 Query: 202 DSLRADG-------FLLSLTVLPN---VNSTWYFDIPALNGLVDFVNLATFDFLTPARNP 251 ++ + + LLS V V++ + D A N +DFVNL +DF Sbjct: 143 NAFQQEAQTSGKERLLLSAAVPAGQTYVDAGYEVDKIAQN--LDFVNLMAYDFHGSWE-- 198 Query: 252 EEADYSAPIYHPDGSKDRLAHLNADFQVEYWLSQGFPSNKINLGVATYGNAWKLTKDSGL 311 + +++P+Y A LN D V+ WL +G P++K+ LG+ TYG ++ L S Sbjct: 199 KVTGHNSPLYKRQEESGAAASLNVDAAVQQWLQKGTPASKLILGMPTYGRSFTLASSSDT 258 Query: 312 E-GVPVVPETSGPAPEGFQSQKPGLLSYAEICGKLSNPQNQFLKGNESPLRRVSDPTKRF 370 G P +G G +++ G+L+Y E+C KG + +R+ D Sbjct: 259 RVGAPA----TGSGTPGPFTKEGGMLAYYEVCS---------WKG--ATKQRIQDQK--- 300 Query: 371 GGIAYRPVDGQITEGIWVSYDDPDSASNKAAYARVKNLGGVALFDLSYDDFRG-QCSGDK 429 + Y D Q WV +DD +S K +Y + K LGG ++ L DDF G C+ + Sbjct: 301 --VPYIFRDNQ-----WVGFDDVESFKTKVSYLKQKGLGGAMVWALDLDDFAGFSCNQGR 353 Query: 430 YPILRAIKYRL 440 YP+++ ++ L Sbjct: 354 YPLIQTLRQEL 364 >2QF8-A nrPDB Length = 361 Score = 146 bits (368), Expect = 2e-35, Method: Compositional matrix adjust. Identities = 120/418 (28%), Positives = 192/418 (45%), Gaps = 69/418 (16%) Query: 24 LVCYYDSSSYTREGLGKLLNPDLEIALQFCSHLVYGYAGLRGENLQAYSMNENLDIYKHQ 83 L+CYY S S REG G PD I C+H++Y +A + + + N+ + +Y Sbjct: 3 LICYYTSWSQYREGDGSCF-PD-AIDPFLCTHVIYSFANISNNEIDTWEWND-VTLY--- 56 Query: 84 FSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDLVKTYG 143 + +LK + P+LK LLSVGG ++ ++ + + + FI+S ++T+G Sbjct: 57 -DTLNTLKNRNPNLKTLLSVGG-----WNYGSQRFSKIASKTQSRRTFIKSVPPFLRTHG 110 Query: 144 FDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTALVRDVKDS 203 FDGLDLA+ +P W+ + L T L KE VR+ + Sbjct: 111 FDGLDLAWLWP-------------GWRDKRHLTT----------LVKEMKAEFVREAQAG 147 Query: 204 LRADGFLLSLTVLP-NVNSTWYFDIPALNGLVDFVNLATFDFLTPARNPEEADYSAPIYH 262 + LLS V + +DI ++ +DF++L T+DF R + + +P++ Sbjct: 148 --TEQLLLSAAVTAGKIAIDRGYDIAQISRHLDFISLLTYDFHGAWR--QTVGHHSPLFR 203 Query: 263 PDGSKDRLAHL-NADFQVEYWLSQGFPSNKINLGVATYGNAWKLTKDSGLEGVPVVPETS 321 G++D + NAD+ V Y L G P+NK+ +G+ T+G ++ L G P+ S Sbjct: 204 --GNEDASSRFSNADYAVSYMLRLGAPANKLVMGIPTFGRSYTLASSKTDVGAPI----S 257 Query: 322 GPAPEGFQSQKPGLLSYAEICGKLSNPQNQFLKGNESPLRRVSDPTKRFGGIAYRPVDGQ 381 GP G ++ G+L+Y EIC L + + P Y Q Sbjct: 258 GPGIPGRFTKWKGILAYYEICDFLHGATTHRFRDQQVP---------------YATKGNQ 302 Query: 382 ITEGIWVSYDDPDSASNKAAYARVKNLGGVALFDLSYDDFRGQCSGDK--YPILRAIK 437 WV+YDD +S NKA Y + + L G ++ L DDFRG G +P+ AIK Sbjct: 303 -----WVAYDDQESVKNKARYLKNRQLAGAMVWALDLDDFRGTFCGQNLTFPLTSAIK 355 >5XEP-A nrPDB Length = 381 Score = 145 bits (367), Expect = 2e-35, Method: Compositional matrix adjust. Identities = 125/438 (28%), Positives = 206/438 (47%), Gaps = 74/438 (16%) Query: 7 FTFVACLFAASTEAASNLVCYYDSSSYTREGLGKLLNPDLEIALQ--FCSHLVYGYAGLR 64 T A L + +A LVCY+ S S REG+G L PD A+Q C+H++Y +A + Sbjct: 7 LTGFAVLMLLQSCSAYKLVCYFTSWSQYREGVGSFL-PD---AIQPFLCTHIIYSFANIS 62 Query: 65 GEN-LQAYSMNENLDIYKHQFSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEG 123 +N L + N+ + + ++ LK + +LK LLSVGG K + Sbjct: 63 SDNMLSTWEWND-----ESNYDKLNKLKTRNTNLKTLLSVGG-----WKFGGKRFSEIAS 112 Query: 124 EKVRQIGFIRSAYDLVKTYGFDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVD 183 R+ F+RS +++YGFDGLDLA+ +P+ + ++ L IK+L Sbjct: 113 NTERRTAFVRSVAPFLRSYGFDGLDLAWLYPRLRDKQYFSTL------IKEL-------- 158 Query: 184 PHAALHKEQFTALVRDVKDSLRADGFLLSLTVLPNVNSTWYFDIPALNGLVDFVNLATFD 243 +FT V+ ++ L L + V + +DI + +DF+NL T+D Sbjct: 159 ------NAEFTKEVQPGREKLLLSAALSAGKVAIDTG----YDIAQIAQHLDFINLMTYD 208 Query: 244 FLTPARNPEEADYSAPIYH--PDGSKDRLAHLNADFQVEYWLSQGFPSNKINLGVATYGN 301 F R + + +P++ D DR +++N + V+Y + G ++K+ +G+ T+G Sbjct: 209 FHGVWR--QITGHHSPLFQGQKDTRFDRYSNVN--YAVQYMIRLGAQASKLLMGIPTFGK 264 Query: 302 AWKLTKDSGLEGVPVVPETSGPAPEGFQSQKPGLLSYAEICGKLSNPQNQFLKGNESPLR 361 ++ L G P+ SG G +++ G L+Y EIC FLKG E + Sbjct: 265 SFTLASSENQLGAPI----SGEGLPGRFTKEAGTLAYYEIC--------DFLKGAE--VH 310 Query: 362 RVSDPTKRFGGIAYRPVDGQITEG-IWVSYDDPDSASNKAAYARVKNLGGVALFDLSYDD 420 R+S+ F T+G WV Y+D +S NK + + K L G ++ L DD Sbjct: 311 RLSNEKVPFA-----------TKGNQWVGYEDKESVKNKVRFLKEKKLAGAMVWALDLDD 359 Query: 421 FRGQCSGDK-YPILRAIK 437 F+G C + +P+ AIK Sbjct: 360 FQGTCQPKEFFPLTNAIK 377 >5Y2C-A nrPDB Length = 383 Score = 145 bits (365), Expect = 5e-35, Method: Compositional matrix adjust. Identities = 128/421 (30%), Positives = 201/421 (47%), Gaps = 59/421 (14%) Query: 24 LVCYYDSSSYTREGLGKLLNPDLEIALQFCSHLVYGYAGLRGENLQAYSMNENLDIYKHQ 83 +VCYY + ++ R GK D I + C+H++Y +A L E L S + LD+ Sbjct: 5 VVCYYTNWAWYRPDNGKYTPGD--INPELCTHIIYAFAVLDKEELVIKSHDIWLDVENKF 62 Query: 84 FSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDLVKTYG 143 + +VT+LK +KVLL +GG D +KY L+ R+ F+ A D ++ YG Sbjct: 63 YEKVTALKSH--GVKVLLGLGG---WDDSAGDKYSRLVNNVSARR-KFVVHAVDFLEQYG 116 Query: 144 FDGLDLAYQFPKNKPRKVHGDLGLAWK-SIKKLFTGDFIVDPHAALHKEQFTALVRDVKD 202 FDGLDL + +PK W+ +K D K+ F LV++++ Sbjct: 117 FDGLDLDWLYPK------------CWQVECEKGPDSD----------KQGFADLVKELRK 154 Query: 203 SLRADGFLLSLTVLPNVNSTWY-FDIPALNGLVDFVNLATFDFLTPARNPEEADYSAPIY 261 + G LLS V + Y +++PAL+ +D+++L T+D+ + ++ + AP+Y Sbjct: 155 AFNRRGMLLSAAVSASKRVIDYAYNVPALSMNLDWISLMTYDY--HGQWDKKTGHVAPMY 212 Query: 262 HPDGSKDRLAHLNADFQVEYWLSQGFPSNKINLGVATYGNAWKLTKDSGLE-GVPVVPET 320 D KD N +F V YW+++G K+ +GV YG ++ + + +G G P T Sbjct: 213 VHD--KDTDNTFNVNFTVNYWINKGADRKKLVVGVPFYGQSFSVVEGAGTGLGAP----T 266 Query: 321 SGPAPEGFQSQKPGLLSYAEICGKLSNPQNQFLKGNESPLRRVSDPTKRFGGIAYRPVDG 380 G +++ G LS+ EIC ++ +KG + DP R G Y D Sbjct: 267 YAGGEAGDETRARGFLSFYEICERVK------VKG----WKVHRDPGGRIG--PYATHDD 314 Query: 381 QITEGIWVSYDDPDSASNKAAYARVKNLGGVALFDLSYDDFRGQ-CSGDKYPILRAIKYR 439 Q WVS+DD A +KA Y R LGG + L DDF G+ C K P+L I + Sbjct: 315 Q-----WVSFDDDFMARHKAEYVRAMELGGSMAWSLDLDDFTGKYCGCGKAPLLTTINHV 369 Query: 440 L 440 L Sbjct: 370 L 370 >1HJW-A nrPDB Length = 362 Score = 139 bits (349), Expect = 3e-33, Method: Compositional matrix adjust. Identities = 111/418 (26%), Positives = 193/418 (46%), Gaps = 68/418 (16%) Query: 24 LVCYYDSSSYTREGLGKLLNPDLEIALQFCSHLVYGYAGLRGENLQAYSMNENLDIYKHQ 83 LVCYY S S REG G L+ L C+H++Y +A + +++ + N+ + +Y Sbjct: 3 LVCYYTSWSQYREGDGSCFPDALDRFL--CTHIIYSFANISNDHIDTWEWND-VTLY--- 56 Query: 84 FSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDLVKTYG 143 + +LK + P+LK LLSVGG + ++ + + R+ FI+S ++T+G Sbjct: 57 -GMLNTLKNRNPNLKTLLSVGGWNF----GSQRFSKIASNTQSRRT-FIKSVPPFLRTHG 110 Query: 144 FDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTALVRDVKDS 203 FDGLDLA+ +P + ++ + ++ K +FI + + +A + K + Sbjct: 111 FDGLDLAWLYPGRRDKQ-------HFTTLIKEMKAEFIKEAQPGKKQLLLSAALSAGKVT 163 Query: 204 LRADGFLLSLTVLPNVNSTWYFDIPALNGLVDFVNLATFDFLTPARNPEEADYSAPIY-- 261 + + +DI ++ +DF+++ T+DF R + +P++ Sbjct: 164 IDSS-----------------YDIAKISQHLDFISIMTYDFHGAWRG--TTGHHSPLFRG 204 Query: 262 HPDGSKDRLAHLNADFQVEYWLSQGFPSNKINLGVATYGNAWKLTKDSGLEGVPVVPETS 321 D S DR + N D+ V Y L G P++K+ +G+ T+G ++ L G P+ S Sbjct: 205 QEDASPDRFS--NTDYAVGYMLRLGAPASKLVMGIPTFGRSFTLASSETGVGAPI----S 258 Query: 322 GPAPEGFQSQKPGLLSYAEICGKLSNPQNQFLKGNESPLRRVSDPTKRFGGIAYRPVDGQ 381 GP G +++ G L+Y EIC L + G + P Y Q Sbjct: 259 GPGIPGRFTKEAGTLAYYEICDFLRGATVHRILGQQVP---------------YATKGNQ 303 Query: 382 ITEGIWVSYDDPDSASNKAAYARVKNLGGVALFDLSYDDFRGQCSGD--KYPILRAIK 437 WV YDD +S +K Y + + L G ++ L DDF+G G ++P+ AIK Sbjct: 304 -----WVGYDDQESVKSKVQYLKDRQLAGAMVWALDLDDFQGSFCGQDLRFPLTNAIK 356 >4P8U-A nrPDB Length = 371 Score = 138 bits (348), Expect = 5e-33, Method: Compositional matrix adjust. Identities = 111/430 (25%), Positives = 190/430 (44%), Gaps = 84/430 (19%) Query: 24 LVCYYDSSSYTREGLGKLLNPDLEIALQFCSHLVYGYAGLRGENLQAYSMNENLDIYKHQ 83 LVCY+ + S R+ GK +++ L CSHL+Y +A + + +E + Sbjct: 10 LVCYFTNWSQDRQEPGKFTPENIDPFL--CSHLIYSFASIENNKVIIKDKSEVM-----L 62 Query: 84 FSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDLVKTYG 143 + + SLK K P LK+LLS+GG +K + ++ FI S ++ + Sbjct: 63 YQTINSLKTKNPKLKILLSIGGYL-----FGSKGFHPMVDSSTSRLEFINSIILFLRNHN 117 Query: 144 FDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTALVRDVKDS 203 FDGLD+++ +P K FT L+ ++ ++ Sbjct: 118 FDGLDVSWIYPDQK-------------------------------ENTHFTVLIHELAEA 146 Query: 204 LRAD-------GFLLSLTVLPN---VNSTWYFDIPALNGLVDFVNLATFDFLTPARNPEE 253 + D LL++ V ++++ + + L +DF+NL +FDF P Sbjct: 147 FQKDFTKSTKERLLLTVGVSAGRQMIDNS--YQVEKLAKDLDFINLLSFDFHGSWEKPLI 204 Query: 254 ADYSAPIYHPDGSKDR--LAHLNADFQVEYWLSQGFPSNKINLGVATYGNAWKLTKDSGL 311 +++P+ G +DR ++ N ++ V YW+ +G PS K+ +G+ TYG+++ L Sbjct: 205 TGHNSPL--SKGWQDRGPSSYYNVEYAVGYWIHKGMPSEKVVMGIPTYGHSFTLASAETT 262 Query: 312 EGVPVVPETSGPAPEGFQSQKPGLLSYAEICGKLSNPQNQFLKGNESPLRRVSDPTKRFG 371 G P SGP G ++ G L+Y EIC QFLKG + Sbjct: 263 VGAPA----SGPGAAGPITESSGFLAYYEIC--------QFLKG------------AKIT 298 Query: 372 GIAYRPVDGQITEGIWVSYDDPDSASNKAAYARVKNLGGVALFDLSYDDFRGQ-CSGDKY 430 + + V + WV YDD S K + + NLGG ++ + DDF G+ C+ Y Sbjct: 299 WLQDQQVPYAVKGNQWVGYDDVKSMETKVQFLKNLNLGGAMIWSIDMDDFTGKSCNQGPY 358 Query: 431 PILRAIKYRL 440 P+++A+K L Sbjct: 359 PLVQAVKRSL 368 >5WUS-A nrPDB Length = 460 Score = 138 bits (347), Expect = 6e-33, Method: Compositional matrix adjust. Identities = 104/427 (24%), Positives = 191/427 (44%), Gaps = 75/427 (17%) Query: 23 NLVCYYDSSSYTREGLGKLLNPDLEIALQFCSHLVYGYAGLRGENLQAYSMNENLDIYKH 82 ++CY S S R G+ + +++ L C+H++Y +A L+ L + ++ D+Y Sbjct: 3 QVLCYLTSWSSKRPSAGRFMPENVDPTL--CTHVIYAFATLKDHKLTE-ADEKDADMY-- 57 Query: 83 QFSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDLVKTY 142 +V +L+ K P+LK+LL++GG + L R F+ A + ++ Y Sbjct: 58 --DKVVALREKNPNLKILLAIGG-----WAFGSTPFKELTSNVFRMNQFVYEAIEFLRDY 110 Query: 143 GFDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTALVRDVKD 202 F+GLD+ +++P+ D AA F +L+++++ Sbjct: 111 QFNGLDVDWEYPRG-------------------------ADDRAA-----FVSLLKELRL 140 Query: 203 SLRADG-------FLLSLTVLPNVNSTWY-FDIPALNGLVDFVNLATFDFLTPARNPEEA 254 + + LL+ V + + +D+P ++ +DF+N+ T+DF + + Sbjct: 141 AFEGEAKTSGQPRLLLTAAVPASFEAIAAGYDVPEISKYLDFINVMTYDFH--GQWERQV 198 Query: 255 DYSAPIYHPDGSKDRLAHLNADFQVEYWLSQGFPSNKINLGVATYGNAWKLTKDSGLE-G 313 +++P++ + + L D+ W+ QG P K+ +G+ TYG ++ L D+ + G Sbjct: 199 GHNSPLFPLESATSYQKKLTVDYSAREWVRQGAPKEKLMIGMPTYGRSFTLINDTQFDIG 258 Query: 314 VPVVPETSGPAPEGFQSQKPGLLSYAEICGKLSNPQNQFLKGNESPLRRVSDPTKRFGGI 373 P SG G + + G +SY EIC L + NE + Sbjct: 259 APA----SGGGQAGRFTNEAGFMSYYEICEFLREDNTTLVWDNEQMV-----------PF 303 Query: 374 AYRPVDGQITEGIWVSYDDPDSASNKAAYARVKNLGGVALFDLSYDDFRGQCSGDKYPIL 433 AYR E WV +DD S K A+ + + GG+ ++ + DDFRG C KYP++ Sbjct: 304 AYR-------EDQWVGFDDERSLKTKMAWLKEEGFGGIMVWSVDMDDFRGSCGTGKYPLI 356 Query: 434 RAIKYRL 440 A+K L Sbjct: 357 TAMKQEL 363 >5WV8-A nrPDB Length = 482 Score = 131 bits (329), Expect = 6e-31, Method: Compositional matrix adjust. Identities = 114/428 (26%), Positives = 189/428 (44%), Gaps = 72/428 (16%) Query: 24 LVCYYDSSSYTREGLGKLLNPDLEIALQFCSHLVYGYAGLRGENLQAYSMN-ENLDIYKH 82 +VCYY + S R +GK + D++ L C+H+++ + L+ L ++ N E D Sbjct: 95 IVCYYTNWSQYRTKIGKFMPEDIQPEL--CTHIIFAFGWLKKGKLSSFESNDETKDGKTG 152 Query: 83 QFSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDLVKTY 142 + + +LK+ P LK LL++GG K+ ++ RQ FI SA ++ Sbjct: 153 LYDRINALKKANPKLKTLLAIGGWSF----GTQKFKEMSATRYARQT-FIYSAIPYLRDR 207 Query: 143 GFDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTALVRDVKD 202 FDGLD+ + +PK K + L L K+L +E F A ++VK Sbjct: 208 NFDGLDIDWLYPKGGDDKKNYVLLL-----KEL--------------REAFEAEAQEVKK 248 Query: 203 SLRADGFLLSLTVLP----NVNSTWYFDIPALNGLVDFVNLATFDFLTPARNPEEADYSA 258 LL +P N+ S +D+PA+ +DF+NL +DF + E ++A Sbjct: 249 PR-----LLLTAAVPVGPDNIKSG--YDVPAVASYLDFINLMAYDF--HGKWERETGHNA 299 Query: 259 PIYHPDGSKDRLAHLNADFQVEYWLSQGFPSNKINLGVATYGNAWKLTKDSGLEGVPVVP 318 P+Y P + L+ D W+ G P K+ +G+ TYG + L+ + + V Sbjct: 300 PLYAPSSDSEWRKQLSVDHAAHLWVKLGAPKEKLIIGMPTYGRTFTLSNPNNFK---VNS 356 Query: 319 ETSGPAPEGFQSQKPGLLSYAEICGKLSNPQNQFLKGNESPLRRVSDPTKRFGGIAYRPV 378 SG G +++ G L+Y E+C L N GG Sbjct: 357 PASGGGKAGEYTKESGFLAYYEVCEILRN-----------------------GGAYVWDD 393 Query: 379 DGQITEGI----WVSYDDPDSASNKAAYARVKNLGGVALFDLSYDDFRGQ-CSGD-KYPI 432 + ++ I WV +DD S NK + + + GG ++ + DDF G C G+ KYP+ Sbjct: 394 EMKVPYAIHGDQWVGFDDEKSIRNKMRWIKDNSFGGAMVWTVDMDDFSGGVCGGNVKYPL 453 Query: 433 LRAIKYRL 440 + A++ L Sbjct: 454 IGAMREEL 461 >3WKZ-A nrPDB Length = 395 Score = 125 bits (315), Expect = 3e-29, Method: Compositional matrix adjust. Identities = 103/426 (24%), Positives = 194/426 (45%), Gaps = 56/426 (13%) Query: 16 ASTEAASNLVCYYDSSSYTREGLGKLLNPDLEIALQFCSHLVYGYAGLRGENLQAYSMNE 75 A +++ + +VCY+ + + R G+G+ D I + C+H++Y + G+ + Q ++ Sbjct: 1 AESDSRARVVCYFSNWAVYRPGVGRYGIED--IPVDMCTHIIYSFIGVTEDTQQVLIIDP 58 Query: 76 NLDIYKHQFSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSA 135 LD+ K+ F TSL+ K+P +K ++VGG + +KY ++ + R + F+RS Sbjct: 59 ELDVDKNGFKNFTSLRSKHPGVKFTVAVGG----WAEGGSKYSKMVAAKSTR-MAFVRSV 113 Query: 136 YDLVKTYGFDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTA 195 D + Y FDGLDL +Q+P R G F K++F Sbjct: 114 VDFLNKYNFDGLDLDWQYPGAADR-----------------GGSFS-------DKDKFLY 149 Query: 196 LVRDVKDSLRADGFLLSLTV---LPNVNSTWYFDIPALNGLVDFVNLATFDFLTPARNPE 252 LV++++ + +G LT L N + +P L +D +++ ++D Sbjct: 150 LVQELRRAFIREGKGWELTAAVPLANFRLMEGYHVPELCQELDAIHVMSYDLR--GNWAG 207 Query: 253 EADYSAPIYHPDGSKDRLAHLNADFQVEYWLSQGFPSNKINLGVATYGNAWKLTKDSGLE 312 AD +P+Y + LN + ++ W +G P+NK+ +G+ YG ++ L+ + Sbjct: 208 FADVHSPLYKRPHDQWAYEKLNVNDGLQLWEDKGCPTNKLVVGIPFYGRSFTLSSGNNNY 267 Query: 313 --GVPVVPETSGPAPEGFQSQKPGLLSYAEICGKLSNPQNQFLKGNESPLRRVSDPTKRF 370 G + E G P + + G +Y EIC ++ +++ TK++ Sbjct: 268 NLGTYINKEAGGGDPAPY-TNATGFWAYYEICTEVDTADSKW--------------TKKW 312 Query: 371 GGIAYRPVDGQITEGIWVSYDDPDSASNKAAYARVKNLGGVALFDLSYDDFRGQCSGDKY 430 P + T+ WV Y+DP S K + + K G + + DDF+G C G+K Sbjct: 313 DEHGKCPYAYKGTQ--WVGYEDPRSVEIKMNWIKEKGYLGAMTWAIDMDDFQGLC-GEKN 369 Query: 431 PILRAI 436 +++ + Sbjct: 370 ILIKLL 375 >3RM8-A nrPDB Length = 395 Score = 125 bits (315), Expect = 3e-29, Method: Compositional matrix adjust. Identities = 109/430 (25%), Positives = 190/430 (44%), Gaps = 79/430 (18%) Query: 24 LVCYYDSSSYTREGLGKLLNPDLEIALQFCSHLVYGYAGLRGENLQAYSMNENLDIYKHQ 83 L CY+ + + R GLG+ + D+ L C+HL+Y +AG++ + N D+ +Q Sbjct: 3 LTCYFTNWAQYRPGLGRFMPDDINPCL--CTHLIYAFAGMQNNEITTIEWN---DVTLYQ 57 Query: 84 FSEVTSLKRKYPHLKVLLSVGG-DHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDLVKTY 142 LK K LK LL++GG + P + ++ + RQ FI S ++ Y Sbjct: 58 --AFNGLKNKNSQLKTLLAIGGWNFGTAP-----FTAMVSTPENRQT-FITSVIKFLRQY 109 Query: 143 GFDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTALVRDVKD 202 FDGLD +++P ++ G D H FT LV+++++ Sbjct: 110 EFDGLDFDWEYPGSR--------------------GSPPQDKHL------FTVLVQEMRE 143 Query: 203 SLRADG-------FLLSLTV---LPNVNSTWYFDIPALNGLVDFVNLATFDFLTPARNPE 252 + + +++ V + N+ S ++IP L+ +D++++ T+D Sbjct: 144 AFEQEAKQINKPRLMVTAAVAAGISNIQSG--YEIPQLSQYLDYIHVMTYDLHGSWEG-- 199 Query: 253 EADYSAPIYHPDGSKDRLAHLNADFQVEYWLSQGFPSNKINLGVATYGNAWKLTKDSGLE 312 ++P+Y A+LN D+ + YW G P+ K+ +G TYG+ + L+ S Sbjct: 200 YTGENSPLYKYPTDTGSNAYLNVDYVMNYWKDNGAPAEKLIVGFPTYGHNFILSNPSNTG 259 Query: 313 -GVPVVPETSGPAPEGFQSQKPGLLSYAEICGKLSNPQNQFLKGNESPLRRVSDPTKRFG 371 G P TSG P G +++ G+ +Y EIC L N Q G ++P Sbjct: 260 IGAP----TSGAGPAGPYAKESGIWAYYEICTFLKNGATQ---GWDAP------------ 300 Query: 372 GIAYRPVDGQITEGIWVSYDDPDSASNKAAYARVKNLGGVALFDLSYDDFRGQ-CSGDKY 430 + V +WV YD+ S KA + + GG ++ + DDF G C+ K+ Sbjct: 301 ----QEVPYAYQGNVWVGYDNVKSFDIKAQWLKHNKFGGAMVWAIDLDDFTGTFCNQGKF 356 Query: 431 PILRAIKYRL 440 P++ +K L Sbjct: 357 PLISTLKKAL 366 >3W4R-A nrPDB Length = 554 Score = 123 bits (308), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 103/431 (23%), Positives = 196/431 (45%), Gaps = 56/431 (12%) Query: 15 AASTEAASNLVCYYDSSSYTREGLGKLLNPDLEIALQFCSHLVYGYAGLRGENLQAYSMN 74 AA +++ + +VCY+ + + R G+G+ D I + C+H++Y + G+ + Q ++ Sbjct: 18 AAESDSRARVVCYFSNWAVYRPGVGRYGIED--IPVDMCTHIIYSFIGVTEDTQQVLIID 75 Query: 75 ENLDIYKHQFSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRS 134 LD+ K+ F TSL+ K+P +K ++VGG + +KY ++ + R + F+RS Sbjct: 76 PELDVDKNGFKNFTSLRSKHPGVKFTVAVGGWAEGG----SKYSKMVAAKSTR-MAFVRS 130 Query: 135 AYDLVKTYGFDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFT 194 D + Y FDGLDL +++P R G F K++F Sbjct: 131 VVDFLNKYNFDGLDLDWEYPGAADRG-----------------GSF-------SDKDKFL 166 Query: 195 ALVRDVKDSLRADGFLLSLTV---LPNVNSTWYFDIPALNGLVDFVNLATFDFLTPARNP 251 LV++++ + +G LT L N + +P L +D +++ ++D Sbjct: 167 YLVQELRRAFIREGKGWELTAAVPLANFRLMEGYHVPELCQELDAIHVMSYDLR--GNWA 224 Query: 252 EEADYSAPIYHPDGSKDRLAHLNADFQVEYWLSQGFPSNKINLGVATYGNAWKLTKDSGL 311 AD +P+Y + LN + ++ W +G P+NK+ +G+ YG ++ L+ + Sbjct: 225 GFADVHSPLYKRPHDQWAYEKLNVNDGLQLWEDKGCPTNKLVVGIPFYGRSFTLSSGNNN 284 Query: 312 E--GVPVVPETSGPAPEGFQSQKPGLLSYAEICGKLSNPQNQFLKGNESPLRRVSDPTKR 369 G + E G P + + G +Y EIC ++ +++ TK+ Sbjct: 285 YNLGTYINKEAGGGDPAPY-TNATGFWAYYEICTEVDTADSKW--------------TKK 329 Query: 370 FGGIAYRPVDGQITEGIWVSYDDPDSASNKAAYARVKNLGGVALFDLSYDDFRGQCSGDK 429 + P + T+ WV Y+DP S K + + K G + + DDF+G C G+K Sbjct: 330 WDEHGKCPYAYKGTQ--WVGYEDPRSVEIKMNWIKEKGYLGAMTWAIDMDDFQGLC-GEK 386 Query: 430 YPILRAIKYRL 440 +++ + + Sbjct: 387 NILIKLLHKHM 397 >1E9L-A nrPDB Length = 377 Score = 110 bits (274), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 107/418 (25%), Positives = 181/418 (43%), Gaps = 59/418 (14%) Query: 23 NLVCYYDSSSYTREGLGKLLNPDLEIALQFCSHLVYGYAGLRGENLQAYSMNENLDIYKH 82 L+CYY S + R G +++ L C+HL+Y +AG++ + Y+ ++L Y+ Sbjct: 2 QLMCYYTSWAKDRPIEGSFKPGNIDPCL--CTHLIYAFAGMQNNEI-TYTHEQDLRDYE- 57 Query: 83 QFSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDLVKTY 142 + LK K LK LL++GG P + ++ + RQI FI+S ++ Y Sbjct: 58 ---ALNGLKDKNTELKTLLAIGGWKF----GPAPFSAMVSTPQNRQI-FIQSVIRFLRQY 109 Query: 143 GFDGLDLAYQFP--KNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTALVRDV 200 FDGL+L +Q+P + P K + K ++K F + + + + T+ + Sbjct: 110 NFDGLNLDWQYPGSRGSPPKDKHLFSVLVKEMRKAFEEESV---EKDIPRLLLTSTGAGI 166 Query: 201 KDSLRADGFLLSLTVLPNVNSTWYFDIPALNGLVDFVNLATFDFLTPARNPEEADYSAPI 260 D +++ + IP L+ +D++ + T+D P ++P+ Sbjct: 167 IDVIKSG-----------------YKIPELSQSLDYIQVMTYDLHDPKDG--YTGENSPL 207 Query: 261 YHPDGSKDRLAHLNADFQVEYWLSQGFPSNKINLGVATYGNAWKLTKDSGLEGVPVVPET 320 Y + A LN D + YW G S K+ +G YG+ + L+ D G+ + Sbjct: 208 YKSPYDIGKSADLNVDSIISYWKDHGAASEKLIVGFPAYGHTFILS-DPSKTGIGAPTIS 266 Query: 321 SGPAPEGFQSQKPGLLSYAEICGKLSNPQNQFLKGNESPLRRVSDPTKRFGGIAYRPVDG 380 +GP G + + GLL+Y E+C L NE P + P Sbjct: 267 TGPP--GKYTDESGLLAYYEVCTFL----------NEGATEVWDAPQE-------VPYAY 307 Query: 381 QITEGIWVSYDDPDSASNKAAYARVKNLGGVALFDLSYDDFRGQ-CSGDKYPILRAIK 437 Q E WV YD+ S KA + + NLGG ++ L DDF G C +P+ +K Sbjct: 308 QGNE--WVGYDNVRSFKLKAQWLKDNNLGGAVVWPLDMDDFSGSFCHQRHFPLTSTLK 363 >6G9C-A nrPDB Length = 495 Score = 108 bits (271), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 105/419 (25%), Positives = 176/419 (42%), Gaps = 67/419 (15%) Query: 26 CYYDSSSYTREGLGKLLNPDLEIALQFCSHLVYGYAGLRGE-NLQAYSMNENLDIYKHQF 84 CY+ + + R G GK NP+ A C ++ Y +A L + + + N+ +D+ + Sbjct: 37 CYFTNWAQYRPGNGKY-NPEHYQA-NLCEYIFYAFAKLNDDFTVDQFEWND-IDVL---Y 90 Query: 85 SEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDLVKTYGF 144 V K P LKVLLS+GG + + + FI S ++ F Sbjct: 91 PGVMKQKSSQPDLKVLLSLGG-----WNAGTATFKKMAATYSNRAKFISSLVSFLQQNKF 145 Query: 145 DGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTALVRDVKDSL 204 DG DL +++P++ ++ + L ++ A +V Sbjct: 146 DGFDLDWEYPESSDKENY------------------------LLLCQEILAKFEEVAKCT 181 Query: 205 RADGFLLSLTVLPNVNST-WYFDIPALNGLVDFVNLATFDFLTPARNPEEADYSAPIYHP 263 L + V N + +D+PAL ++DFVNL +DF + ++P+Y Sbjct: 182 STSRLLFTAAVSANPKTVDAGYDVPALAKVLDFVNLMCYDFHGAWET--QTGINSPLYSR 239 Query: 264 DGSKDRLAHLNADFQVEYWLSQGFPSNKINLGVATYGNAWKLTKDSGLE-GVPVVPETSG 322 N + +YW +G P +I +G+ TYG W L+ S + G P + S Sbjct: 240 KEDSSEFKMWNVEQSSKYWSDKGMPKKQIIIGLPTYGRGWTLSDASKTDIGAPA--QGSS 297 Query: 323 PAPEGFQSQKPGLLSYAEICGKLSNPQNQFLKGNESPLRRVSDPTKRFGGIAYRPVDGQI 382 A E + + G++SY E+C KLS S +RV D + + + Sbjct: 298 TATEYLR--EAGVISYYEVCQKLS-----------SGAKRVWDDESKTPYL--------V 336 Query: 383 TEGIWVSYDDPDSASNKAAYARVKNLGGVALFDLSYDDFRGQ-CS---GDKYPILRAIK 437 W SYDD +S K + + +N GG ++ L YDDF G C+ G KYP++ ++ Sbjct: 337 QGNQWFSYDDVESMKAKINWIKQENYGGAFVWTLDYDDFLGSFCTEHNGKKYPLISLMQ 395 >6BT9-A nrPDB Length = 672 Score = 102 bits (254), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 93/372 (25%), Positives = 167/372 (44%), Gaps = 61/372 (16%) Query: 75 ENLDIYKH--QFSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFI 132 E+ D Y F E+ LK KYPHLK ++SVGG N++ D+ EK R++ F Sbjct: 134 EDCDKYARCGNFGELKRLKAKYPHLKTIISVGG-----WTWSNRFSDMAADEKTRKV-FA 187 Query: 133 RSAYDLVKTYGFDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQ 192 S ++ YGFDG+DL +++P ++ + G + + K+ Sbjct: 188 ESTVAFLRAYGFDGVDLDWEYP----------------GVETIPGGSYRPE-----DKQN 226 Query: 193 FTALVRDVKDSLRADG------FLLSLTVLPNVNSTWYFDIPALNGLVDFVNLATFDFLT 246 FT L++DV+++L G +LL++ + + ++ ++ ++D++N+ T+DF Sbjct: 227 FTLLLQDVRNALNKAGAEDGKQYLLTIASGASQRYADHTELKKISQILDWINIMTYDFHG 286 Query: 247 PARNPEEADYSAPIYHPDGSKDRLAHLNADFQVEYWLSQGFPSNKINLGVATYGNAWK-L 305 ++++A +Y + D + + ++G P +K+ LGV YG WK Sbjct: 287 GWE--ATSNHNAALYKDPNDPAANTNFYVDGAINVYTNEGVPVDKLVLGVPFYGRGWKSC 344 Query: 306 TKDSGLEGVPVVPETSGP-APEG----FQSQKPGLLSYAEICGKLSNPQNQFLKGNESPL 360 K++ + P P + G A +G + + G+ Y ++ N +N F+ Sbjct: 345 GKENNGQYQPCKPGSDGKLASKGTWDDYSTGDTGVYDYGDLAANYVN-KNGFV------- 396 Query: 361 RRVSDPTKRFGGIAYRPVDGQITEGIWVSYDDPDSASNKAAYARVKNLGGVALFDLSYD- 419 + + A P T G ++SYDD +S K Y + K L G ++LS D Sbjct: 397 -------RYWNDTAKVPYLYNATTGTFISYDDNESMKYKTDYIKTKGLSGAMFWELSGDC 449 Query: 420 --DFRGQCSGDK 429 + CSG K Sbjct: 450 RTSPKYSCSGPK 461 >3QOK-A nrPDB Length = 420 Score = 88.2 bits (217), Expect = 7e-18, Method: Compositional matrix adjust. Identities = 89/353 (25%), Positives = 160/353 (45%), Gaps = 59/353 (16%) Query: 84 FSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDLVKTYG 143 ++ +L+++ P LKVLLSVGG + + R + FIRSA +++ YG Sbjct: 95 LQKLPALRKQNPDLKVLLSVGGWG------ARGFSGAAATAESRAV-FIRSAQKIIQQYG 147 Query: 144 FDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTALVRDVKDS 203 DG+DL ++FP V+G GL ++ FTAL++ ++++ Sbjct: 148 LDGIDLDWEFP------VNGAWGLV---------------ASQPADRDNFTALLKSLREA 186 Query: 204 LRADGFLLSLTVLPNVNS--TWYFDIPALNGLVDFVNLATFDFLTPARNPEEADYSAPIY 261 + + L+++ V N S +W D+ A+ +++++NL T+D + Y + + Sbjct: 187 V-GEQKLVTIAVGANAESPKSW-VDVKAVAPVLNYINLMTYDMAYGTQYFNSNLYDSSHW 244 Query: 262 HPDGSKDRLAHLNADFQVEYWLSQGFPSNKINLGVATYGNAWKLTKDSGLEGV------- 314 + D+ + ADF V +L+ G +++NLG+ YG K + G++ Sbjct: 245 PTVAAADKYS---ADFVVNNYLAAGLKPSQMNLGIGFYGRVPKRAVEPGIDWTKADAQNN 301 Query: 315 PVVPETSGP------APEGFQSQKPGLLSYAEICGKLSN-PQNQFLKGNESPLRRVSDPT 367 PV GP A G+ K + Y +I GKL N PQ +F + D Sbjct: 302 PVTQPYFGPQQIALFASLGYDLSKDTYVKYNDIVGKLLNDPQKRFTEH--------WDDE 353 Query: 368 KRFGGIAYRPVDGQITEGIWVSYDDPDSASNKAAYARVKNLGGVALFDLSYDD 420 + ++ + +G+ + SY++P S + KA Y + K L G ++ DD Sbjct: 354 AKVPWLSVQSAEGKPLFAL--SYENPRSVAIKADYIKAKGLAGAMFWEYGADD 404 >6F8N-A nrPDB Length = 414 Score = 82.8 bits (203), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 88/342 (25%), Positives = 152/342 (44%), Gaps = 49/342 (14%) Query: 90 LKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDLVKTYGFDGLDL 149 L+++ P LKVLLSVGG + + R + FIRS ++K Y DG+DL Sbjct: 86 LRKQNPELKVLLSVGGWG------ARGFSGAAATAESRAV-FIRSVQQVIKQYHLDGIDL 138 Query: 150 AYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTALVRDVKDSLRADGF 209 +Q+P V+G GL V+ A + FT L+ ++ +L G Sbjct: 139 DWQYP------VNGAWGL--------------VESQPA-DRANFTLLLAELHKALD-KGK 176 Query: 210 LLSLTVLPNVNS-TWYFDIPALNGLVDFVNLATFDFLTPARNPEEADYSAPIYHPDGSKD 268 LL++ V NV S + D+ + +D++NL T+D + Y + + + D Sbjct: 177 LLTIAVGANVKSPQEWVDVKGIAPYLDYINLMTYDMAYGTQYFNSNLYDSKQWPTVAAAD 236 Query: 269 RLAHLNADFQVEYWLSQGFPSNKINLGVATYGNAWKLTKDSGLEGVPVVPETSGPAPEGF 328 R + A+F V+ +L+ G ++NLG+ YG K + G++ + F Sbjct: 237 RYS---ANFVVDNYLAAGLKPAQLNLGIGFYGRVPKRATEPGIDWDKADAAKNPVTQPYF 293 Query: 329 QSQKPGLLSYAEICGKLSNPQNQFLKGNESPLRRVSDPTKRFGGIAYRPVDGQI------ 382 +++ + L ++ + K N+ + ++DP +RF A+ D Q+ Sbjct: 294 TARETAVFK----AMGLDLTKDSYFKYNDIVSKLLNDPQRRF--TAHWDSDAQVPYLTMK 347 Query: 383 -TEG---IWVSYDDPDSASNKAAYARVKNLGGVALFDLSYDD 420 EG +SY++P S + KA Y + K LGG ++ DD Sbjct: 348 SAEGKPLFAISYENPRSVALKADYIKSKGLGGAMFWEYGADD 389 >3WD0-A nrPDB Length = 503 Score = 80.9 bits (198), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 96/375 (25%), Positives = 156/375 (41%), Gaps = 74/375 (19%) Query: 85 SEVTSLKRKYPHLKVLLSVGG---DHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDLVKT 141 + +T+LK P L+++ S+GG +D+ H N Y++ ++ R F +S ++K Sbjct: 80 NRLTALKAHNPSLRIMFSIGGWYYSNDLGVSHAN-YVNAVKTPAAR-TKFAQSCVRIMKD 137 Query: 142 YGFDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTALVRDVK 201 YGFDG+D+ +++P+ +V G + A + I+ L I D AL + A Sbjct: 138 YGFDGVDIDWEYPQAA--EVDGFIA-ALQEIRTLLNQQTIADGRQALPYQLTIAGA---- 190 Query: 202 DSLRADGFLLSLTVLPNVNSTWYFDIPALNGLVDFVNLATFDFLTP---ARNPEEA---D 255 F LS +Y + + +D++NL T+D P N + A D Sbjct: 191 ----GGAFFLS---------RYYSKLAQIVAPLDYINLMTYDLAGPWEKITNHQAALFGD 237 Query: 256 YSAPIYHPDGSKDRLA--------------HLNADFQVE-YWLSQGFPSNKINLGVATYG 300 + P ++ + L L D V+ + + +G PS KI +GV YG Sbjct: 238 AAGPTFYNALREANLGWSWEELTRAFPSPFSLTVDAAVQQHLMMEGVPSAKIVMGVPFYG 297 Query: 301 NAWKLTKDSGLEGVPVVPETSGPAP------------EGFQSQKPGLLSYAEICGKLSNP 348 A+K G G T G P E + + P + SY ++ Sbjct: 298 RAFKGVS-GGNGGQYSSHSTPGEDPYPNADYWLVGCDECVRDKDPRIASYRQL------- 349 Query: 349 QNQFLKGNESPLRRVSDPTKRFGGIAYRPVDGQITEGIWVSYDDPDSASNKAAYARVKNL 408 Q L+GN R +D TK P G++V+YDD +S KA Y + + L Sbjct: 350 -EQMLQGNYGYQRLWNDKTKT-------PYLYHAQNGLFVTYDDAESFKYKAKYIKQQQL 401 Query: 409 GGVALFDLSYDDFRG 423 GGV + L D+ G Sbjct: 402 GGVMFWHLGQDNRNG 416 >5GZU-A nrPDB Length = 885 Score = 80.9 bits (198), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 93/362 (25%), Positives = 152/362 (41%), Gaps = 81/362 (22%) Query: 87 VTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDLVKTYGFDG 146 +T LK K P+LKVL+S+GG + D + R++ F SA D + Y DG Sbjct: 100 LTGLKAKNPNLKVLVSIGGWE------AEGFSDAALTPESREV-FANSALDFMNKYNLDG 152 Query: 147 LDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTALVRDVKDSLRA 206 +DL +++P V+G AW IK P K FTAL++ +++ L A Sbjct: 153 IDLDWEYP------VYG----AWGVIKS--------RPE---DKANFTALLKLLREKLDA 191 Query: 207 DG------FLLSLTVLPNVNSTWYFDIPALNGLVDFVNLATFDF---LTPARNPEEADYS 257 + L++ + T ++ + +D++NL T+D PA + A YS Sbjct: 192 QSTTTNKYYELAIAAGASKTYTDSVELTKITPYLDYINLMTYDLHGGWDPATSHHTAVYS 251 Query: 258 APIYHPDGSKDRLAHLNADFQVEYWLSQGFPSNKINLGVATYGNAWKLTKDSGLEGVPVV 317 A L+ D V+ +L+ G P+ K+ +G A Y W+ ++ G Sbjct: 252 A----------TNNQLSVDSTVKLYLNNGVPAEKLMVGGAFYSRVWQNVENKG------- 294 Query: 318 PETSGPAPEGFQSQKPGLLSYAEICGKLSNPQNQFLKGNESPLRRVSDPTKR----FGGI 373 T G Q+ PG + Y+E+ N ++ N++ R D T + F G Sbjct: 295 --TGLSEKAGSQAGSPGTIVYSELV-------NNYI--NKNGYTRYWDDTAKAPYLFNGS 343 Query: 374 AYRPVDGQITEGIWVSYDDPDSASNKAAYARVKNLGGVALFDLSYDDFRGQCSGDKYPIL 433 + +SY+D SA+ KA Y + NL G ++ S D + + Y L Sbjct: 344 TF------------ISYEDTASAAYKAEYIKQNNLAGFMYWEYSQDSDSHELANTIYSRL 391 Query: 434 RA 435 A Sbjct: 392 YA 393 Score = 62.0 bits (149), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 91/365 (24%), Positives = 159/365 (43%), Gaps = 71/365 (19%) Query: 83 QFSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDLVKTY 142 F+ + +LK++ P LKVL+S+GG + D + R+ SA + Y Sbjct: 582 NFAYLKTLKQQNPSLKVLVSIGGWA------AEGFSDAALTPETRE-ELANSAIAFMHQY 634 Query: 143 GFDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTALVRDVKD 202 GFDG+DL +++P V+G G+ IK P K+ FTAL++ ++ Sbjct: 635 GFDGIDLDWEYP------VYGAFGV----IKS--------RPE---DKQNFTALLKLFRE 673 Query: 203 SLRADGFL--------LSLTVLP-NVNSTWYFDIPALNGLVDFVNLATFDFLTPARNPEE 253 L +G L ++ P +NS ++ ++ +D++++ T+D+ + + Sbjct: 674 KLDVEGALHGKYYELAIASAAAPIYINSV---ELDKIHQYLDYMSVMTYDYHGSWES--K 728 Query: 254 ADYSAPIYHPDGSKDRLAHLNADFQVEYWLSQGFPSNKINLGVATYGNAWKLTKDSGLEG 313 + A +Y S +AD + + QG P++K+ +G A Y W Sbjct: 729 TAHQASVYTSALSP---GDFSADSVLTAYRKQGVPASKLVIGGAFYARGW---------- 775 Query: 314 VPVVPETSGPAPE-GFQSQKPGLLSYAEICGKLSNPQNQFLKGNESPLRRVSDPTKRFGG 372 V V G + G Q++ PG +Y ++ ++ F KG R D + + Sbjct: 776 VNVPNINHGLFQQAGDQAKNPGTPTYNDLV------KDYFDKG----YTRYWDNSAK-AP 824 Query: 373 IAYRPVDGQITEGIWVSYDDPDSASNKAAYARVKNLGGVALFDLSYDDFRGQCSGDKYPI 432 Y P G +++YDD +S KA YA+ + L GV +D S D G+ G + Sbjct: 825 YLYNP---DANGGTFITYDDEESLKYKAEYAKNQGLRGVMFWDYS-QDISGKLLGAIFNE 880 Query: 433 LRAIK 437 L+A K Sbjct: 881 LKAPK 885 >5GQB-A nrPDB Length = 553 Score = 80.1 bits (196), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 90/351 (25%), Positives = 154/351 (43%), Gaps = 64/351 (18%) Query: 80 YKHQFSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDLV 139 YK F ++ LK+ P LK+L S+GG DP + + K R+ F+ S D + Sbjct: 242 YKGNFGQLMMLKQAKPDLKILPSIGGWTLADP-----FFFFTDETKRRR--FVASVKDFL 294 Query: 140 KTYGF-DGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTALVR 198 +T+ F DG+D+ ++FP K + +LG S K G+ V L KE +R Sbjct: 295 QTWKFFDGVDIDWEFPGGK--GANPNLG----SPKD---GEIYV----LLMKE-----LR 336 Query: 199 DVKDSLRADG---FLLSLTVLPNVNSTWYFDIPALNGLVDFVNLATFDFLTPARNPEEAD 255 ++ + L A+ + L+ + + D A +D + ++DF N + Sbjct: 337 EMLNELSAETGRKYELTSAISAGWDKIQVVDYSAAQKYMDHIFFMSYDFKGAWSN-DTLG 395 Query: 256 YSAPIYHPDGSKDRLAHLNADFQVEYWLSQGFPSNKINLGVATYGNAWKLTKDSGLEGV- 314 + A +Y PD ++ DF V++ L+QG KI +GVA YG W +G+ G Sbjct: 396 HQASLYAPDWNEKET--YTTDFGVQFLLAQGVSPKKIVVGVAMYGRGW-----TGVHGYK 448 Query: 315 ---PVVPETSGPAPEGFQSQKPGLLSYAEICGKLSNPQNQFL--KGNESPLRRVSDPTKR 369 P +GP +Q G++ Y EI +++ + ++ K ++P Sbjct: 449 DNNPFTGNATGPVKGTWQD---GVVDYREIATEIAQGKWEYHYDKVAQAPY--------- 496 Query: 370 FGGIAYRPVDGQITEGIWVSYDDPDSASNKAAYARVKNLGGVALFDLSYDD 420 +RP G + ++YDD S K Y R LGG+ +++ D+ Sbjct: 497 ----VFRPATGDL-----ITYDDARSTIEKGKYVRANKLGGLFAWEIDADN 538 >4MNK-A nrPDB Length = 348 Score = 77.0 bits (188), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 96/389 (24%), Positives = 156/389 (40%), Gaps = 87/389 (22%) Query: 44 PDLEIALQFCSHLVYGYAGLRGENLQAYSMNENLDIYKHQFSEVTSLKRKYPHLKVLLSV 103 P +I + +HL Y +A L N + + K +++R P +K L+S+ Sbjct: 19 PPSKINSRLFTHLYYAFAEL---NAPTFEVRVPPGSEKTAEDFTPTVRRLNPSVKTLISI 75 Query: 104 GGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDLVKTYGFDGLDLAYQFPKNKPRKVHG 163 GG D+ + L RQ F++S+ L + YGF GLDL Y++P+ + Sbjct: 76 GGGGSEVRDN---FAKLNSDASARQ-RFVKSSIALARRYGFHGLDLDYEYPEPQ------ 125 Query: 164 DLGLAWKSIKKLFTGDFIVDPHAALHKEQFTALVRDVKDSLRADG-------FLLSLTV- 215 L E F LV ++ ++R + LL+ V Sbjct: 126 ------------------------LEMENFVKLVSELTAAIREEARTSGKPRLLLTEAVY 161 Query: 216 -----LPNVNSTWYFDIPALNGLVDFVNLATFDFLTPARNPEEADYSAPIYHPDGSKDRL 270 P T Y + + +D+VN+ +DF N A P +D Sbjct: 162 FHQKLFPWEVVTEY-PVQFIAAGLDWVNVMAYDFHGSWENFTGA--------PAALRDPN 212 Query: 271 AHLNADFQVEYWLSQGFPSNKINLGVATYGNAWKLTKDSGLEGVPVVPETSGPAPEGFQS 330 + A +E +L+ G P K+ LG+ +G +W L K++ G+ +GP Sbjct: 213 SKFTASVGIESFLAAGMPPEKLVLGIPLFGRSW-LLKNNNEVGIGAPAVGAGPVD----- 266 Query: 331 QKPGLLSYAEICGKLSNPQNQFLKGNESPLRRVSDPTKRFGGIAYRPVDGQITEGIWVSY 390 G LS++EI QN F++G R V D T AY+ + +WV Y Sbjct: 267 ---GALSFSEI-------QN-FIRGGA---REVFD-TTTVSAYAYK-------DNVWVGY 304 Query: 391 DDPDSASNKAAYARVKNLGGVALFDLSYD 419 D+ S + K YA+ K LGG + ++ D Sbjct: 305 DNQQSVALKVQYAKEKRLGGYFFWSVNQD 333 >3ALF-A nrPDB Length = 353 Score = 75.9 bits (185), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 91/372 (24%), Positives = 159/372 (42%), Gaps = 63/372 (16%) Query: 54 SHLVYGYAGLRGENLQAYSMNENLDIYKHQFSEVTSLKRKYPHLKVLLSVGGDHDIDPDH 113 +HL +A L + Q EN D ++ QF+ ++++RK P +K LS+ G + Sbjct: 26 THLFCAFADLNPQLNQLIISPENQDSFR-QFT--STVQRKNPSVKTFLSIAGGRANSTAY 82 Query: 114 PNKYIDLLEGEKVRQIGFIRSAYDLVKTYGFDGLDLAYQFPKNKPRKVHGDLGLAWKSIK 173 ++ + + FI S+ L + GF GLDL +++P L+ + Sbjct: 83 -----GIMARQPNSRKSFIDSSIRLARQLGFHGLDLDWEYP------------LSAADMT 125 Query: 174 KLFTGDFIVDPHAALHKEQFTALVRDVKDSLRADGFLLSLTVL--PNVNSTWYFDIPALN 231 L T L E TA+ + ++S RA LL+ V P VN Y + +L Sbjct: 126 NLGT----------LLNEWRTAINTEARNSGRA-ALLLTAAVSNSPRVNGLNY-PVESLA 173 Query: 232 GLVDFVNLATFDFLTPARNPEEADYSAPIYHPDGSKDRLAHLNADFQVEYWLSQGFPSNK 291 +D++NL +DF P +P + + A ++ P + H++ + W+ G P+ K Sbjct: 174 RNLDWINLMAYDFYGPNWSPSQTNSHAQLFDP------VNHVSGSDGINAWIQAGVPTKK 227 Query: 292 INLGVATYGNAWKLTKDSGLEGVPVVPETSGPAPEGFQSQKPGLLSYAEICGKLSNPQNQ 351 + LG+ YG AW+L ++ + G+ +G + G + G ++Y I + Sbjct: 228 LVLGIPFYGYAWRLV-NANIHGLRA--PAAGKSNVG--AVDDGSMTYNRIRDYIV----- 277 Query: 352 FLKGNESPLRRVSDPTKRFGGIAYRPVDGQITEGIWVSYDDPDSASNKAAYARVKNLGGV 411 ES V + T G Y + W+SYDD + NK Y + + L G Sbjct: 278 -----ESRATTVYNATI-VGDYCYSGSN-------WISYDDTQTVRNKVNYVKGRGLLGY 324 Query: 412 ALFDLSYDDFRG 423 + ++ D G Sbjct: 325 FAWHVAGDQNWG 336 >1ITX-A nrPDB Length = 419 Score = 72.0 bits (175), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 82/348 (23%), Positives = 149/348 (42%), Gaps = 61/348 (17%) Query: 83 QFSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDLVKTY 142 +++ LK+ P+LK ++SVGG N++ D+ R++ F SA D ++ Y Sbjct: 109 NINQLNKLKQTNPNLKTIISVGG-----WTWSNRFSDVAATAATREV-FANSAVDFLRKY 162 Query: 143 GFDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTALVRDVKD 202 FDG+DL +++P +G + K+ +T L+ +++ Sbjct: 163 NFDGVDLDWEYP---------------------VSGGLDGNSKRPEDKQNYTLLLSKIRE 201 Query: 203 SLRA----DGFLLSLTVLPNVNSTWY--FDIPALNGLVDFVNLATFDFLTPARNPEEADY 256 L A DG LT+ ++T+ ++ + +VD++N+ T+DF + + + + Sbjct: 202 KLDAAGAVDGKKYLLTIASGASATYAANTELAKIAAIVDWINIMTYDFNGAWQ--KISAH 259 Query: 257 SAPI-YHPDGSKDRLAHLNADFQV----EYWLSQGFPSNKINLGVATYGNAWKLTKDSGL 311 +AP+ Y P S + N F V + L G P+ K+ LGV YG W +G Sbjct: 260 NAPLNYDPAASAAGVPDANT-FNVAAGAQGHLDAGVPAAKLVLGVPFYGRGWDGCAQAGN 318 Query: 312 EGVPVVPETSGPAPEGFQSQKPGLLSYAEICGKLSNPQNQFLKGNESPLRRVSDPTKRFG 371 T G + +++ G + ++ N +N + T+ + Sbjct: 319 GQYQTC--TGGSSVGTWEA---GSFDFYDLEANYIN-KNGY--------------TRYWN 358 Query: 372 GIAYRPVDGQITEGIWVSYDDPDSASNKAAYARVKNLGGVALFDLSYD 419 A P + ++SYDD +S K AY + K LGG ++LS D Sbjct: 359 DTAKVPYLYNASNKRFISYDDAESVGYKTAYIKSKGLGGAMFWELSGD 406 >5ZL9-A nrPDB Length = 618 Score = 72.0 bits (175), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 85/351 (24%), Positives = 143/351 (40%), Gaps = 58/351 (16%) Query: 78 DIYKHQFSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYD 137 D YK F ++ +LK+ +P LK+L S+GG DP G+KV++ F+ S + Sbjct: 224 DPYKGNFGQLMALKQAHPDLKILPSIGGWTLSDP-------FFFMGDKVKRDRFVGSVKE 276 Query: 138 LVKTYG-FDGLDLAYQFPKNK---PRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQF 193 ++T+ FDG+D+ ++FP K P G + + K K + Sbjct: 277 FLQTWKFFDGVDIDWEFPGGKGANPNLGSPQDGETYVLLMKELRAMLDQLSVETGRKYEL 336 Query: 194 TALVRDVKDSLRADGFLLSLTVLPNVNSTWYFDIPALNGLVDFVNLATFDFLTPARNPEE 253 T+ + KD + D F + V N + G D NL + Sbjct: 337 TSAISAGKDKI--DKFYSFVNVAQNSMDHIFLMSYDFYGAFDLKNLG-----------HQ 383 Query: 254 ADYSAPIYHPDGSKDRLAHLNADFQVEYWLSQGFPSNKINLGVATYGNAWKLTKDSGLEG 313 +AP + PD + + +NA L+QG KI +G A YG W +G+ G Sbjct: 384 TALNAPAWKPDTAYTTVNGVNA------LLAQGVKPGKIVVGTAMYGRGW-----TGVNG 432 Query: 314 ----VPVVPETSGPAPEGFQSQKPGLLSYAEICGKLSNPQNQFLKGNESPLRRVSDPTKR 369 +P +GP +++ G++ Y +I G QF+ G + D T Sbjct: 433 YQNNIPFTGTATGPVKGTWEN---GIVDYRQIAG-------QFMSGE---WQYTYDATAE 479 Query: 370 FGGIAYRPVDGQITEGIWVSYDDPDSASNKAAYARVKNLGGVALFDLSYDD 420 ++P G + +++DD S K Y K LGG+ +++ D+ Sbjct: 480 -APYVFKPSTGDL-----ITFDDARSVQAKGKYVLDKQLGGLFSWEIDADN 524 >5Z7M-A nrPDB Length = 546 Score = 71.2 bits (173), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 88/354 (24%), Positives = 155/354 (43%), Gaps = 62/354 (17%) Query: 78 DIYKHQFSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYD 137 D YK F ++ +LK+ +P LK+L S+GG DP G+KV++ F+ S + Sbjct: 224 DPYKGNFGQLMALKQAHPDLKILPSIGGWTLSDP-------FFFMGDKVKRDRFVGSVKE 276 Query: 138 LVKTYG-FDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTAL 196 ++T+ FDG+D+A++FP K + +LG + + L KE L Sbjct: 277 FLQTWKFFDGVDIAWEFPGGK--GANPNLGSPQDG-----------ETYVLLMKELRAML 323 Query: 197 VRDVKDSLRADGFLLSLTVLPNVNSTWYFDIPALNGLVDFVNLATFDFLTPA--RN-PEE 253 + ++ R +++ ++ +++ A N + D + L ++DF A +N + Sbjct: 324 DQLSVETGRKYELTSAISAGKDMIDKVAYNV-AQNSM-DHIFLMSYDFYGAADLKNLGHQ 381 Query: 254 ADYSAPIYHPDGSKDRLAHLNADFQVEYWLSQGFPSNKINLGVATYGNAWKLTKDSGLEG 313 +AP + PD + + +NA L+QG KI +G A YG W +G+ G Sbjct: 382 TALNAPAWKPDTAYTTVNGVNA------LLAQGVKPGKIVVGTAMYGRGW-----TGVNG 430 Query: 314 ----VPVVPETSGPAPEGFQSQKPGLLSYAEICGKLSNPQNQFLKGNESPLRRVSDPTKR 369 +P +GP +++ G++ Y +I G QF+ G + D T Sbjct: 431 YQNNIPFTGTATGPVKGTWEN---GIVDYRQIAG-------QFMSGE---WQYTYDATAE 477 Query: 370 FGGIAYRPVDGQITEGIWVSYDDPDSASNKAAYARVKNLGGV--ALFDLSYDDF 421 ++P G + +++DD S K Y K LGG+ A+ D D Sbjct: 478 -APYVFKPSTGDL-----ITFDDARSVQAKGKYVLDKQLGGLFSAMIDADNGDI 525 >3AQU-A nrPDB Length = 356 Score = 70.1 bits (170), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 88/382 (23%), Positives = 145/382 (37%), Gaps = 66/382 (17%) Query: 44 PDLEIALQFCSHLVYGYAGLRGENLQAYSMNENLDIYKHQFSEVT-SLKRKYPHLKVLLS 102 P +I +HL +A L + Q + N + +FS T +++R+ P +K LLS Sbjct: 17 PVTDIDSSLFTHLFCAFADLNSQTNQVTVSSAN----QPKFSTFTQTVQRRNPSVKTLLS 72 Query: 103 VGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDLVKTYGFDGLDLAYQFPKNKPRKVH 162 +GG Y + R+ FI S+ + ++YGF GLDL +++P + + Sbjct: 73 IGGGIA----DKTAYASMASNPTSRK-SFIDSSIRVARSYGFHGLDLDWEYPSSATEMTN 127 Query: 163 GDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTALVRDVKDSLRADGFLLSLTVLPNVNST 222 L +E +A+V + S + L + N + Sbjct: 128 ----------------------FGTLLREWRSAVVAEASSSGKPRLLLAAAVFYSNNYYS 165 Query: 223 WYFDIPALNGLVDFVNLATFDFLTPARNPEEADYSAPIYHPDGSKDRLAHLNADFQVEYW 282 + + A+ +D+VNL +DF P + A ++ P A + D W Sbjct: 166 VLYPVSAVASSLDWVNLMAYDFYGPGWSRVTGP-PAALFDPSN-----AGPSGDAGTRSW 219 Query: 283 LSQGFPSNKINLGVATYGNAWKLTKDSGLEGVPVVPETSGPAPEGFQSQKP-GLLSYAEI 341 + G P+ K LG YG AW+LT + S AP + P G + Y +I Sbjct: 220 IQAGLPAKKAVLGFPYYGYAWRLTNAN---------SHSYYAPTTGAAISPDGSIGYGQI 270 Query: 342 CGKLSNPQNQFLKGNESPLRRVSDPTKRFGGIAYRPVDGQITEGIWVSYDDPDSASNKAA 401 +F+ N + S G Y + W+ YDD S K Sbjct: 271 --------RKFIVDNGATTVYNS---TVVGDYCYAGTN-------WIGYDDNQSIVTKVR 312 Query: 402 YARVKNLGGVALFDLSYDDFRG 423 YA+ + L G + + DD G Sbjct: 313 YAKQRGLLGYFSWHVGADDNSG 334 >4TXG-A nrPDB Length = 793 Score = 69.3 bits (168), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 100/417 (23%), Positives = 167/417 (40%), Gaps = 103/417 (24%) Query: 80 YKHQFSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIR------ 133 YK F+ +T KRKYP +K L+SVGG + Y D G++V GF Sbjct: 229 YKGHFNLLTQYKRKYPGVKTLISVGGWAET-----GGYFD-ANGKRVASGGFYSMTVNAD 282 Query: 134 -------------SAYDLVKTYGFDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDF 180 SA ++ YGFDG+D+ +++P + + A + F+ Sbjct: 283 GTVNQAGINAFSDSAVAFLRKYGFDGVDIDFEYPTS--------MNNAGNPLDWTFSNAR 334 Query: 181 IVDPHAALHKEQFTALVRDVKDSL-RA---DGFLLSLTVLPNVNSTWYFDIPALNGL--V 234 + +L+K + AL++ ++D L RA DG +T + + GL + Sbjct: 335 L----GSLNKG-YVALLQTLRDRLDRAAAQDGRYYQITAAVPASGYLLRGMETFQGLKYL 389 Query: 235 DFVNLATFD-------FLTP-------ARNPEEA---DYSAPIYHPDGSKDRLAHLNADF 277 DFVN+ ++D F+ P ++ E A YS P Y + +LN D+ Sbjct: 390 DFVNVMSYDLHGAWNRFVGPNAALYDDGKDAELAFWNVYSTPQY------GNIGYLNTDW 443 Query: 278 QVEYWLSQGFPSNKINLGVATYGNAWKLTK--DSGLEGVPVVPETSGPAPEGFQSQKPGL 335 Y+ G P++++N+GV Y WK +GL G V P G G Sbjct: 444 AYHYYRG-GLPASRVNMGVPYYTRGWKNVSGGSNGLWGSSVGSN----CPAGLTECGDGA 498 Query: 336 LSYAEICGKLSNPQNQFLKGNESPLRRVS----------------DPT-----------K 368 + I L + + + G +P+ DPT + Sbjct: 499 VGIDNIWHDLDDSGKE-IPGGSNPMWHAKNLEKGLAGSYLAAYGIDPTLPINQLTGSYQR 557 Query: 369 RFGGIAYRPVDGQITEGIWVSYDDPDSASNKAAYARVKNLGGVALFDLSYD-DFRGQ 424 + G P + +++S +D S + KAA+ N+GGV ++L+ D D++ Q Sbjct: 558 NYNGALAAPWLWNAGKKVFLSTEDEQSIAQKAAWIDANNVGGVMFWELAGDYDWKAQ 614 >3CHF-A nrPDB Length = 433 Score = 64.3 bits (155), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 99/400 (24%), Positives = 162/400 (40%), Gaps = 85/400 (21%) Query: 39 GKLLNPDLEIALQFCSHLVYGYAGLRGENLQAYSMNENLDIYKHQ--------------- 83 G+ NP ++ ++ +H++Y +A +R E + Y + DI KH Sbjct: 56 GRNHNPQ-DLPVERLTHVLYAFANVRPETGEVYMTDSWADIEKHYPGDSWSDTGNNVYGC 114 Query: 84 FSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDLVKTYG 143 ++ LK++ +LKVLLS+GG P D G K F ++A L++ G Sbjct: 115 IKQLYLLKKQNRNLKVLLSIGGWTYSPNFAPAASTD--AGRK----NFAKTAVKLLQDLG 168 Query: 144 FDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTALVRDVKDS 203 FDGLD+ +++P+N + DF++ L KE TAL D + Sbjct: 169 FDGLDIDWEYPENDQQ-----------------ANDFVL-----LLKEVRTAL--DSYSA 204 Query: 204 LRADG--FLLSLTVLPNVNSTWYFDIPALNGLVDFVNLATFDFLTPARNPEEADYSAPIY 261 A G FLL++ + + ++ +DF NL +D+ + + A +Y Sbjct: 205 ANAGGQHFLLTVASPAGPDKIKVLHLKDMDQQLDFWNLMAYDY--AGSFSSLSGHQANVY 262 Query: 262 HPDGSKDRLAHLNADFQVEYWLSQGFPSNKINLGVATYGNAWKLTKDSG--LEGVPVVPE 319 + D S N ++ + + G P+NKI LG+ YG ++ T G GV Sbjct: 263 N-DTSNPLSTPFNTQTALDLYRAGGVPANKIVLGMPLYGRSFANTDGPGKPYNGV----- 316 Query: 320 TSGPAPEGFQSQKPGLLSYAEICGKLSNPQNQFLKGNESPLRRVSDPTKRFGGIAYRPVD 379 G S + G+ Y + PQ E L + +A D Sbjct: 317 -------GQGSWENGVWDYKAL------PQ---AGATEHVLPDI---------MASYSYD 351 Query: 380 GQITEGIWVSYDDPDSASNKAAYARVKNLGGVALFDLSYD 419 T +SYD+P A+ K+ Y + LGG +D S D Sbjct: 352 A--TNKFLISYDNPQVANLKSGYIKSLGLGGAMWWDSSSD 389 >4URI-A nrPDB Length = 337 Score = 61.2 bits (147), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 81/339 (23%), Positives = 125/339 (36%), Gaps = 69/339 (20%) Query: 84 FSEVT-SLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDLVKTY 142 FS T +++ K P +K LLS+ + + R+ FI S+ L + Sbjct: 50 FSTFTQTVRAKNPSVKTLLSI---GGGGGRALAAVFANMASQASRRKSFIDSSIQLARRN 106 Query: 143 GFDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTALVRDVKD 202 F GLDL +++P + I K I + AA+ E T+ Sbjct: 107 NFHGLDLDWEYPSSD--------------IDKTNFASLIREWRAAVATESSTS------- 145 Query: 203 SLRADGFLLSLTV--LPNVNSTWYFDIPALNGLVDFVNLATFDFLTPARNPEEADYSAPI 260 LLS V + Y+ A+ +D+VN+ T+D T P AP+ Sbjct: 146 --GTPALLLSAAVGGSDQITPLKYYPGEAIANNLDWVNVMTYDLYTSDSYPTLTQPPAPL 203 Query: 261 YHPDGSKDRLAHLNADFQVEYWLSQGFPSNKINLGVATYGNAWKLTKDSGLEGVPVVPET 320 ++P G +AD + W+ G P +K+ LG+ YG W+L+ D G+ Sbjct: 204 FYPRGI------FSADEGITKWIQSGVPESKLALGLPFYGFKWRLS-DPNNHGL------ 250 Query: 321 SGPAPEGFQSQKPGLLSYAEICGKLSNPQNQFLKGNESPLRRVSDPTKRFGGIAYRPVDG 380 PA +G G + Y +I G + RF G Sbjct: 251 FAPATQGL-----GAVKYKDIVN----------TGGQVEFDSTYVTNYRFKGTD------ 289 Query: 381 QITEGIWVSYDDPDSASNKAAYARVKNLGGVALFDLSYD 419 W YDD S S K AYA+ + L G + + D Sbjct: 290 ------WYGYDDTQSISAKVAYAKQRGLFGYFAWHIEQD 322 >4W5U-B nrPDB Length = 408 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 87/348 (25%), Positives = 134/348 (38%), Gaps = 70/348 (20%) Query: 81 KHQFSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDLV- 139 + F+++ LK KYPH+KVL S GG + D + + GF +S Y+LV Sbjct: 117 RGNFNQLRQLKAKYPHIKVLWSFGG-----WTWSGGFADAAKDPQ----GFAQSCYNLVH 167 Query: 140 --KTYG-FDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTAL 196 + G FDG+D+ +++P GL S + + + E TA Sbjct: 168 DPRWDGVFDGIDIDWEYPNA--------CGLTCDSSGPDAFRNLMAALRSTFGDELVTAA 219 Query: 197 VRDVKDSLRADGFLLSLTVLPNVNSTWYFDIPALNGLVDFVNLATFDFLTPARNPEEADY 256 V ADG T + +T D VD+ N+ T+DF Sbjct: 220 V-------TADG-----TPGGKIEAT---DYAGAAQYVDWYNVMTYDFFGAWDAQGPTAP 264 Query: 257 SAPIYHPDGSKDRLAHLNADFQVEYWLSQGFPSNKINLGVATYGNAWKLTKDSGLEGVPV 316 +P+ DG + +AD + + +QG P++K+ LG+ YG W G Sbjct: 265 HSPLTSYDGIP-KQGFTSAD-AIAAFKAQGVPADKLLLGIGFYGRGWTGVTQDAPGGTAT 322 Query: 317 VPETSGPAPEGFQSQKPGLLSYAEICGKLSNPQNQFLKGNESPLRRVSDPTKRFGGIAYR 376 P +G +G + K LK N P+ T G AY Sbjct: 323 GP-AAGTWEQGIEDYK-------------------VLK-NTCPV------TGTVAGTAYA 355 Query: 377 PVDGQITEGIWVSYDDPDSASNKAAYARVKNLGGVALFDLSYDDFRGQ 424 +W SYD PD+ ++K A+A + L G +D S D G+ Sbjct: 356 ----HCGSNLW-SYDTPDTIASKMAWANDQGLRGAFAWDFSGDTADGE 398 >5DF0-A nrPDB Length = 545 Score = 57.0 bits (136), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 80/346 (23%), Positives = 140/346 (40%), Gaps = 55/346 (15%) Query: 80 YKHQFSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDLV 139 YK F ++ + K PHLK+L S+GG DP + ++ +E V F+ S + + Sbjct: 239 YKGNFGQLMAAKLANPHLKILPSIGGWTLSDPFY---FMHDVEKRNV----FVDSVKEFL 291 Query: 140 KTYG-FDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTALVR 198 + + FDG+D+ ++FP K + LG A + K L E+ A++ Sbjct: 292 QVWKFFDGVDVDWEFPGGK--GANPSLGDAERDAKTYI-----------LLLEELRAMLD 338 Query: 199 DVKDSLRADGFLLSLTVLPNVNSTWYFDIPALNGLVDFVNLATFDFLTPARNPEEADYSA 258 D+ ++ + L+ + + + + + L ++DF N + Y Sbjct: 339 DL-EAQTGRVYELTSAISAGYDKIAVVNYAEAQKSLGKIFLMSYDFKGAWSNTDLG-YQT 396 Query: 259 PIYHPDGSKDRLAHLNADFQVEYWLSQGFPSNKINLGVATYGNAW----KLTKDSGLEGV 314 +Y P + + L + V+ L QG NKI +GVA YG W T D+ G Sbjct: 397 TVYAPSWNSEEL--YTTHYAVDALLKQGVDPNKIIVGVAMYGRGWTGVTNYTNDNYFSGT 454 Query: 315 PVVPETSGPAPEGFQSQKPGLLSYAEICGKLSNPQNQFLKGNESPLRRVSDPTKRFGGIA 374 +GP ++ G++ Y +I L+N F ++ V D +K Sbjct: 455 -----GNGPVSGTWED---GVVDYRQIQKDLNNYVYTFDSAAQASY--VFDKSK------ 498 Query: 375 YRPVDGQITEGIWVSYDDPDSASNKAAYARVKNLGGVALFDLSYDD 420 G +S+D DS K Y LGG+ +++ D+ Sbjct: 499 ----------GDLISFDSVDSVLGKVKYVDRNKLGGLFAWEIDADN 534 >3ARQ-A nrPDB Length = 584 Score = 55.1 bits (131), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 84/364 (23%), Positives = 150/364 (41%), Gaps = 61/364 (16%) Query: 81 KHQFSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDLVK 140 K ++ + +LK++ P LK++ S+GG DP + D ++ K + F+ S +K Sbjct: 229 KGNYAMLMALKQRNPDLKIIPSIGGWTLSDP-----FYDFVD--KKNRDTFVASVKKFLK 281 Query: 141 TYGF-DGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTALVRD 199 T+ F DG+D+ ++FP GD + D A + AL+R+ Sbjct: 282 TWKFYDGVDIDWEFPGGGGAAAD--------------KGDPVNDGPA------YIALMRE 321 Query: 200 VK---DSLRAD-GFLLSLTVLPNVNSTWYFDIPALNGL--VDFVNLATFDFLTPARNP-- 251 ++ D L A+ G LT V D+ + + +D++ T+DF N Sbjct: 322 LRVMLDELEAETGRTYELTSAIGVGYDKIEDVDYADAVQYMDYIFAMTYDFYGGWNNVPG 381 Query: 252 -EEADYSAPIYHP----------DGSKDRLAHLNADFQVEYWLSQGFPSNKINLGVATYG 300 + A Y P +G + AD ++ L+QG P+NK+ LG A YG Sbjct: 382 HQTALYCGSFMRPGQCDGGGVDENGEPYKGPAYTADNGIQLLLAQGVPANKLVLGTAMYG 441 Query: 301 NAWK-LTKDSGLEGVPVVPETSGPAPEGFQSQ---KPGLLSYAEICGKLSNPQNQFLKGN 356 W+ +T D+ + + T+ +G +Q + G++ Y I + N + G Sbjct: 442 RGWEGVTPDTLTDPNDPMTGTATGKLKGSTAQGVWEDGVIDYKGIKSFMLGANNTGINGF 501 Query: 357 ESPLRRVSDPTKRFGGIAYRPVDGQITEGIWVSYDDPDSASNKAAYARVKNLGGVALFDL 416 E + A P + G +++DD S K YA+ L G+ +++ Sbjct: 502 E----------YGYDAQAEAPWVWNRSTGELITFDDHRSVLAKGNYAKSLGLAGLFSWEI 551 Query: 417 SYDD 420 D+ Sbjct: 552 DADN 555 >1LL6-A nrPDB Length = 392 Score = 51.6 bits (122), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 68/287 (23%), Positives = 120/287 (41%), Gaps = 48/287 (16%) Query: 39 GKLLNPDLEIALQFCSHLVYGYAGLRGENLQAYSMNENLDIYKHQ--------------- 83 G+ NP A QF +H++Y +A +R + Y + D KH Sbjct: 16 GRGHNPQDLKADQF-THILYAFANIRPSG-EVYLSDTWADTDKHYPGDKWDEPGNNVYGC 73 Query: 84 FSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDLVKTYG 143 ++ LK+ +LK LLS+GG P+ EG K F ++ L+K G Sbjct: 74 IKQMYLLKKNNRNLKTLLSIGG-WTYSPNFKTP-ASTEEGRKK----FADTSLKLMKDLG 127 Query: 144 FDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTALVRDVKDS 203 FDG+D+ +++P+++ K D L K+ ++ +D ++A H Sbjct: 128 FDGIDINWEYPEDE--KQANDFVLLLKACRE------ALDAYSAKHP------------- 166 Query: 204 LRADGFLLSLTVLPNVNSTWYFDIPALNGLVDFVNLATFDFLTPARNPEEADYSAPIYHP 263 FLL++ + + ++ +DF NL +DF + + ++ P Sbjct: 167 -NGKKFLLTIASPAGPQNYNKLKLAEMDKYLDFWNLMAYDF---SGSWDKVSGHMSNVFP 222 Query: 264 DGSKDRLAHLNADFQVEYWLSQGFPSNKINLGVATYGNAWKLTKDSG 310 +K ++D V+ ++ G P+NKI LG+ YG A+ T G Sbjct: 223 STTKPESTPFSSDKAVKDYIKAGVPANKIVLGMPLYGRAFASTDGIG 269 >3G6L-A nrPDB Length = 406 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 88/423 (20%), Positives = 168/423 (39%), Gaps = 85/423 (20%) Query: 16 ASTEAASNLVCYYDSSSYTREGL-GKLLNP-DLEIALQFCSHLVYGYAGLRGENLQAYSM 73 AST+ ++ ++ +T G+ G+ P DL+ + H++Y + LR + YS Sbjct: 10 ASTDLSTRATGSINAVYFTNWGIYGRNFQPADLQASKIL--HVLYSFMNLRVDG-TVYSG 66 Query: 74 NENLDIYKHQ---------------FSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYI 118 + D+ KH ++ LK+ LK++LS+GG + Sbjct: 67 DTYADLEKHYSDDSWNDIGTNAYGCVKQLYKLKKANRSLKIMLSIGG-----WTWSTNFP 121 Query: 119 DLLEGEKVRQIGFIRSAYDLVKTYGFDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTG 178 E R F ++A + +K +GFDG+D+ +++P ++ ++ L + +++ Sbjct: 122 AAASTEATRAT-FAKTAVEFMKDWGFDGIDVDWEYPASETDA--NNMVLLLQRVRQE--- 175 Query: 179 DFIVDPHAALHKEQFTALVRDVKDSLRADGFLLSLTVLPNVNSTWY--FDIPALNGLVDF 236 +D ++A + A+G+ L++ + Y + L ++D Sbjct: 176 ---LDSYSATY----------------ANGYHFQLSIAAPAGPSHYNVLKLAQLGSVLDN 216 Query: 237 VNLATFDFLTPARNPEEADYSAPIYHPDGSKDRLAHLNADFQVEYWLSQGFPSNKINLGV 296 +NL +D+ A + + +P S + V+ +++ G P++KI LG+ Sbjct: 217 INLMAYDY---AGSWDSVSGHQTNLYPSTSNPSSTPFSTKAAVDAYIAAGVPASKIILGM 273 Query: 297 ATYGNAWKLTKDSGLEGVPVVPETSGPAPEGFQSQKPGLLSYAEICGKLSNPQNQFLKGN 356 YG A+ G +G P P ++ G S + G+ Y + Sbjct: 274 PIYGRAFV-----GTDG-PGKPYST----IGEGSWESGIWDYKVL--------------- 308 Query: 357 ESPLRRVSDPTKRFGGIAYRPVDGQITEGIWVSYDDPDSASNKAAYARVKNLGGVALFDL 416 P + T G Y T +SYD PD K +YA+ LGG ++ Sbjct: 309 --PKAGATVITDSAAGATYSYDSSSRTM---ISYDTPDMVRTKVSYAKGLGLGGSMFWEA 363 Query: 417 SYD 419 S D Sbjct: 364 SAD 366 >6EPB-A nrPDB Length = 423 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 73/340 (21%), Positives = 136/340 (40%), Gaps = 73/340 (21%) Query: 86 EVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDLVKTYGFD 145 ++ +K+ LKVLLS+GG + P+ + F ++A +K +GFD Sbjct: 111 QLFKVKKANRGLKVLLSIGG-WTWSTNFPSA-----ASTDANRKNFAKTAITFMKDWGFD 164 Query: 146 GLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTALVRDVKDSLR 205 G+D+ +++P + + ++ L K ++ +D +AA + + Sbjct: 165 GIDIDWEYPADATQA--SNMILLLKEVRSQ------LDAYAAQYAPGYH----------- 205 Query: 206 ADGFLLSLTVLPNVNSTWYFDIPALNGLVDFVNLATFDF---LTPARNPEEADYSAPIYH 262 FLL++ ++ + L ++D++NL +D+ +P + ++ P Sbjct: 206 ---FLLTIAAPAGKDNYSKLRLADLGQVLDYINLMAYDYAGSFSPLTGHDANLFNNP--- 259 Query: 263 PDGSKDRLAHLNADFQVEYWLSQGFPSNKINLGVATYGNAWKLTKDSG--LEGVPVVPET 320 S N D V+ +++ G P+NKI LG+ YG +++ T G GV Sbjct: 260 ---SNPNATPFNTDSAVKDYINGGVPANKIVLGMPIYGRSFQNTAGIGQTYNGV------ 310 Query: 321 SGPAPEGFQSQKPGLLSYAEICGKLSNPQ-NQFLKGNESPLRRVSDPTKRFGGIAYRPVD 379 G S + G+ Y + + Q + KG S + TK Sbjct: 311 ------GSGSWEAGIWDYKALPKAGATVQYDSVAKGYYS----YNSATKEL--------- 351 Query: 380 GQITEGIWVSYDDPDSASNKAAYARVKNLGGVALFDLSYD 419 +S+D PD + K AY + LGG ++ S D Sbjct: 352 --------ISFDTPDMINTKVAYLKSLGLGGSMFWEASAD 383 >1KFW-A nrPDB Length = 435 Score = 45.1 bits (105), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 93/361 (25%), Positives = 138/361 (38%), Gaps = 82/361 (22%) Query: 84 FSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDL----- 138 F+++ LK K P LKV++S+GG + E RQ + S DL Sbjct: 105 FNQLKQLKAKNPKLKVMISLGG-----WTWSKNFSKAAATEASRQK-LVSSCIDLYIKGN 158 Query: 139 -----------VKTYGFDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAA 187 FDG+D+ +++P + GLA + D + D Sbjct: 159 LPNFEGRGGAGAAAGIFDGIDIDWEWPGT-------NSGLAGNGV------DTVND---- 201 Query: 188 LHKEQFTALVRDVKDSLRADG------FLLS--LTVLPNVNSTWYFDIPALNGLVDFVNL 239 + F AL+ + + L A G ++LS L P +D PA +DF ++ Sbjct: 202 --RANFKALLAEFRKQLDAYGSTNNKKYVLSAFLPANPADIDAGGWDDPANFKSLDFGSI 259 Query: 240 ATFDFLTPARNPEEADYSAPIYH-PDGSKDRLAHLNADFQVEYWLSQGFPSNKINLGVAT 298 +D L A NP + A +Y P + +AD V+ +L+ G ++ LG+A Sbjct: 260 QGYD-LHGAWNPTLTGHQANLYDDPADPRAPSKKFSADKAVKKYLAAGIDPKQLGLGLAA 318 Query: 299 YGNAWKLTKDSGLEGVPVVPETSGPAPEGFQSQKPGLLSYAEICGKLSNPQNQFLKGNES 358 YG W K+ V P GPA +G PG A N LK Sbjct: 319 YGRGWTGAKN-------VSPW--GPATDG----APGTYETA-------NEDYDKLK---- 354 Query: 359 PLRRVSDPTKRFGGIAYRPVDGQITEGIWVSYDDPDSASNKAAYARVKNLGGVALFDLSY 418 +D G A+R DG W SYD+ + K Y K LGG ++LS Sbjct: 355 --TLGTDHYDAATGSAWR-YDGT----QWWSYDNIATTKQKTDYIVSKGLGGGMWWELSG 407 Query: 419 D 419 D Sbjct: 408 D 408 >5XWF-A nrPDB Length = 378 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 69/303 (22%), Positives = 122/303 (40%), Gaps = 45/303 (14%) Query: 131 FIRSAYDLVKTYGFDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHK 190 F+ + D+VK Y DGL+L +++P N P G+A S + T +++ Sbjct: 86 FVSNLVDVVKEYDLDGLNLDWEYP-NSPN------GVACNSKDENDTANYL--------- 129 Query: 191 EQFTALVRDVKDSLRADGFLLSLTVLPNVNSTWYFDIPALN------GLVDFVNLATFDF 244 L + +++ L + L T +P P+ VD + +D Sbjct: 130 ----KLFKALREKLGSKTILT--TAVPTAPFNDENQQPSTKLDDNWASTVDAFYIMAYD- 182 Query: 245 LTPARNPEEADYSAPIYHPDGSKDRLAHLNADFQVEYWLSQGFPSNKINLGVATYGNAWK 304 + R+ + A +AP+Y+ + + + V+ W++ G P+ ++ LGV YG K Sbjct: 183 VNGIRD-KNAGANAPLYYSPKVT-GVEPTSGNDAVKAWIAAGIPAEQLVLGVPFYGRVSK 240 Query: 305 LTKDSGLEGVPVVPETSGPAPEGFQSQKPGLLS---YAEIC-GKLSNPQNQFL---KGNE 357 + P+ T P SQ G + A+ C ++ Q++ E Sbjct: 241 TLE-------PITASTGLYVPISQSSQIKGDSTDEKAADPCPNAVATYSGQYIWRTIAQE 293 Query: 358 SPLRRVSDPTKRFGGIAYRPVDGQITEGIWVSYDDPDSASNKAAYARVKNLGGVALFDLS 417 R S + I+ P + +S+DD S +K YA+ + LGGV L+ L Sbjct: 294 GIARNSSGWVTYWDDISKTPYAYSFSGSKVLSFDDAASLQDKVDYAKKQGLGGVMLWSLE 353 Query: 418 YDD 420 DD Sbjct: 354 MDD 356 >5JH8-A nrPDB Length = 317 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 46/204 (22%), Positives = 83/204 (40%), Gaps = 27/204 (13%) Query: 114 PNKYIDLLEGEKVRQIGFIRSAYDLVKTYGFDGLDLAYQFPKNKPRKVHGDLGLAWKSIK 173 PN I L G K+ G + + V G D+A+ + + +L + + K Sbjct: 49 PNDAISFLLGRKIPAYGCVSN----VDGNGNWSADIAHAVSTSAQSQAVANL-VKFAQDK 103 Query: 174 KLFTGDFIVDPHAALHKEQFTALVRDVKDSLRADGFLLSLTVLP------NVNSTWYFDI 227 + + + A + F+ ++ + +L A G L ++V N + + +D+ Sbjct: 104 RFSGINVDFEAVAQGDRNNFSHFIQVLGRALHAKGLKLIVSVPAFSAKDENHPANYGYDL 163 Query: 228 PALNGLVDFVNLATFDFLTPARNPEEADYSAPIYHPDGSKDRLAHLNADFQVEYWLSQGF 287 AL D++ + ++D PA +P P+ D +D L D+ VE Sbjct: 164 RALGAAADYLQIMSYDEAIPAWDP------GPVAGSDWMEDDL-----DYAVER-----V 207 Query: 288 PSNKINLGVATYGNAWKLTKDSGL 311 P+ KI G+ YG WK D G+ Sbjct: 208 PAAKILNGIPAYGYDWKRPGDGGM 231 >3CZ8-A nrPDB Length = 319 Score = 37.7 bits (86), Expect = 0.011, Method: Compositional matrix adjust. Identities = 31/129 (24%), Positives = 58/129 (44%), Gaps = 20/129 (15%) Query: 186 AALHKEQFTALVRDVKDSLRADGFLLSLTVLPNV--NSTWY--FDIPALNGLVDFVNLAT 241 +A ++ FT +R ++D L+A G++L++ V N W +D + +V+++ + Sbjct: 123 SAADRDLFTGFLRQLRDRLQAGGYVLTIAVPAKTSDNIPWLRGYDYGGIGAVVNYMFIMA 182 Query: 242 FDFLTPARNPEEADYSAPIYHPDGSKDRLAHLNADFQVEYWLSQGFPSNKINLGVATYGN 301 +D+ P API + +E+ ++Q PS KI +GV YG Sbjct: 183 YDWHHAGSEPGPV---APITEIRRT------------IEFTIAQ-VPSRKIIIGVPLYGY 226 Query: 302 AWKLTKDSG 310 W + G Sbjct: 227 DWIIPYQPG 235 >4DWS-C nrPDB Length = 546 Score = 35.0 bits (79), Expect = 0.060, Method: Compositional matrix adjust. Identities = 52/189 (27%), Positives = 78/189 (41%), Gaps = 31/189 (16%) Query: 231 NGLVDFVNLATFDFLTPARNPEEADY---SAPIYHP-DGSKDRLAHLNADFQVEYWLSQ- 285 NGL D + L ++DF ADY +Y P D + L L+A+ ++Y ++ Sbjct: 327 NGL-DNIYLMSYDFFGTIW----ADYIGHHTNLYSPKDPGEQELFDLSAEAAIDYLHNEL 381 Query: 286 GFPSNKINLGVATYGNA---WKLTKDSGLEGVPVVPETSGPAPEGFQSQKPGLLSYAEIC 342 G P KI+LG A YG + LT + P + APE F K +Y + Sbjct: 382 GIPMEKIHLGYANYGRSAVGGDLTTRQYTKNGPALGTMENGAPEFFDIVK----NYMDAE 437 Query: 343 GKLSNPQNQFLKGNESPLRRVSDPTKRFGGIAYRPVDGQITEGIWVSYDDPDSASNKAAY 402 LS +N F+ ++ +D F +G ++S D P + K Y Sbjct: 438 HSLSMGKNGFVLMTDTN----ADADFLF----------SEAKGHFISLDTPRTVKQKGEY 483 Query: 403 ARVKNLGGV 411 A LGGV Sbjct: 484 AAKNKLGGV 492 >6OGD-C nrPDB Length = 633 Score = 34.7 bits (78), Expect = 0.085, Method: Compositional matrix adjust. Identities = 52/189 (27%), Positives = 78/189 (41%), Gaps = 31/189 (16%) Query: 231 NGLVDFVNLATFDFLTPARNPEEADY---SAPIYHP-DGSKDRLAHLNADFQVEYWLSQ- 285 NGL D + L ++DF ADY +Y P D + L L+A+ ++Y ++ Sbjct: 414 NGL-DNIYLMSYDFFGTIW----ADYIGHHTNLYSPKDPGEQELFDLSAEAAIDYLHNEL 468 Query: 286 GFPSNKINLGVATYGNA---WKLTKDSGLEGVPVVPETSGPAPEGFQSQKPGLLSYAEIC 342 G P KI+LG A YG + LT + P + APE F K +Y + Sbjct: 469 GIPMEKIHLGYANYGRSAVGGDLTTRQYTKNGPALGTMENGAPEFFDIVK----NYMDAE 524 Query: 343 GKLSNPQNQFLKGNESPLRRVSDPTKRFGGIAYRPVDGQITEGIWVSYDDPDSASNKAAY 402 LS +N F+ ++ +D F +G ++S D P + K Y Sbjct: 525 HSLSMGKNGFVLMTDTN----ADADFLF----------SEAKGHFISLDTPRTVKQKGEY 570 Query: 403 ARVKNLGGV 411 A LGGV Sbjct: 571 AAKNKLGGV 579 >4WIW-A nrPDB Length = 349 Score = 34.7 bits (78), Expect = 0.088, Method: Compositional matrix adjust. Identities = 29/127 (22%), Positives = 56/127 (44%), Gaps = 20/127 (15%) Query: 181 IVDPHAALHKEQFTALVRDVKDSLRADGFLLSLTVLPNVNSTWY----FDIPALNGLVDF 236 + DP+ + + TA + + L++ L+ + V+P ++S+ Y +D AL+ VD+ Sbjct: 129 VKDPYDGV-RNDLTAFMESLHSELQSMNKLVVMAVMPRMSSSQYWLDAYDYEALSHAVDY 187 Query: 237 VNLATFDFLTPARNPEEADYSAPIYHPDGSKDRLAHLNADFQVEYWLSQGFPSNKINLGV 296 +++ T+D P PI K L ++ QG +K+ +G+ Sbjct: 188 LHVMTYDHHYRTSAP------GPIAPYPWIKQVLTYIQG---------QGVDMSKVLMGI 232 Query: 297 ATYGNAW 303 YG W Sbjct: 233 PYYGRDW 239 >4TX8-A nrPDB Length = 439 Score = 33.1 bits (74), Expect = 0.28, Method: Compositional matrix adjust. Identities = 19/52 (36%), Positives = 28/52 (53%), Gaps = 10/52 (19%) Query: 98 KVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDLVKTYGFDGLDL 149 KV+LS+GG N + L +V+ F+ S Y ++ YGFDG+DL Sbjct: 176 KVVLSLGGQ--------NGSVTLNNATQVQN--FVNSLYGILTQYGFDGIDL 217 >4S3J-A nrPDB Length = 433 Score = 32.7 bits (73), Expect = 0.34, Method: Compositional matrix adjust. Identities = 37/127 (29%), Positives = 54/127 (42%), Gaps = 23/127 (18%) Query: 190 KEQFTALVRDVKDSLRADGFLLSLTVLPNVNSTW---YF---DIPALNGLVDFVNLATFD 243 +E + +R+VK L G+ LS T++P +S +F D A +VDFV + T+D Sbjct: 227 REAYNRFLRNVKIRL-PSGYTLSTTLVPKTSSNQKGKFFEAHDYKAQGQIVDFVVIMTYD 285 Query: 244 FLTPARNPEEADYSAPIYHPDGSKDRLAHLNADFQVEYWLSQGFPSNKINLGVATYGNAW 303 + P P+ K+ L +Y SQ P KI +G YG W Sbjct: 286 WGWQGGPPMAISPIGPV------KEVL---------QYAKSQ-MPPQKIMMGQNLYGFDW 329 Query: 304 KLTKDSG 310 KL G Sbjct: 330 KLPFKQG 336 >4S3K-A nrPDB Length = 436 Score = 32.3 bits (72), Expect = 0.45, Method: Compositional matrix adjust. Identities = 33/129 (25%), Positives = 54/129 (41%), Gaps = 22/129 (17%) Query: 190 KEQFTALVRDVKDSLRADGFLLSLTVLPNVN----STWY--FDIPALNGLVDFVNLATFD 243 KE + A ++ K L+ + L+S+ + P + WY D A+ + +FV T++ Sbjct: 228 KEAYIAFLQKAKKRLQDEQLLMSVALAPKTSRDQKGKWYEAHDYKAIGEIANFVVPMTYE 287 Query: 244 FLTPARNPEEADYSAPIYHPDGSKDRLAHLNADFQVEYWLSQGFPSNKINLGVATYGNAW 303 + P P+ +D L EY +S+ PS+KI +G YG W Sbjct: 288 WGYSGGPPMAVSPIGPV------RDVL---------EYAVSE-IPSSKIIMGQNLYGYDW 331 Query: 304 KLTKDSGLE 312 L G E Sbjct: 332 TLPYKPGGE 340 >3N18-A nrPDB Length = 333 Score = 31.2 bits (69), Expect = 1.0, Method: Compositional matrix adjust. Identities = 21/65 (32%), Positives = 34/65 (52%), Gaps = 12/65 (18%) Query: 85 SEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDLVKTYGF 144 S+++ LK K KV+LS+GG + + +L + + FI S L+ YGF Sbjct: 63 SDISYLKSK--GKKVVLSIGGQNGV----------VLLPDNAAKDRFINSIQSLIDKYGF 110 Query: 145 DGLDL 149 DG+D+ Sbjct: 111 DGIDI 115 >1NAR-A nrPDB Length = 290 Score = 30.4 bits (67), Expect = 1.5, Method: Compositional matrix adjust. Identities = 21/84 (25%), Positives = 39/84 (46%), Gaps = 7/84 (8%) Query: 72 SMNENLDIYKHQFSEVTSLKRKYPHLKVLLSVGG---DHDIDPDHPNKYIDLLEGEKVRQ 128 + E+ D+ +V +LKR++P +KV++S+GG + DP N ++ Sbjct: 53 TFEESWDVELFGPEKVKNLKRRHPEVKVVISIGGRGVNTPFDPAEENVWV----SNAKES 108 Query: 129 IGFIRSAYDLVKTYGFDGLDLAYQ 152 + I Y DG+D+ Y+ Sbjct: 109 LKLIIQKYSDDSGNLIDGIDIHYE 132 >3IAN-A nrPDB Length = 321 Score = 30.0 bits (66), Expect = 1.9, Method: Compositional matrix adjust. Identities = 13/29 (44%), Positives = 19/29 (65%) Query: 121 LEGEKVRQIGFIRSAYDLVKTYGFDGLDL 149 +E +K ++ F+ LV TYGFDGLD+ Sbjct: 93 IELKKSQESDFVNEIIRLVDTYGFDGLDI 121 >4Q6T-A nrPDB Length = 351 Score = 30.0 bits (66), Expect = 2.1, Method: Compositional matrix adjust. Identities = 35/187 (18%), Positives = 72/187 (38%), Gaps = 43/187 (22%) Query: 124 EKVRQIGFIRSAYDLVKTYGFDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVD 183 ++ G ++ L K GF G++L F K +PR Sbjct: 94 DRALSAGTVKQLVKLAKEGGFAGINL--DFEKVEPR------------------------ 127 Query: 184 PHAALHKEQFTALVRDVKDSLRADGFLLSLTVLPNVNST-----WYFDIPALNGLVDFVN 238 ++ F A V+ + ++L A L +++ P ++ T +D AL VD+ Sbjct: 128 -----NRAAFCAFVKTLGNALHASNKKLIISIPPKLSDTEPEYLQGYDYKALGAAVDYFQ 182 Query: 239 LATFDFLTPARNPEEADYSAPIYHPDGSKDRLAHLNADFQVEYWLSQGFPSNKINLGVAT 298 + T+D + P +S+ +H + + + + + P++K+ G+ T Sbjct: 183 VMTYDQVGPG-------WSSGGFHNEAWPGPESGFDWQQALLSYAVSRVPASKVLAGLPT 235 Query: 299 YGNAWKL 305 YG + + Sbjct: 236 YGQDYSI 242 >2BPA-1 nrPDB Length = 426 Score = 29.6 bits (65), Expect = 2.8, Method: Compositional matrix adjust. Identities = 25/70 (35%), Positives = 36/70 (51%), Gaps = 13/70 (18%) Query: 166 GLAWKSIKKLFTGDFIVDPHAALHKEQFTALVRDVKDSLRADGFLLSLTVLPNVNSTWYF 225 GLA S +FT F V PH ++ EQ+ ++ +KD + A T LP VN+T Y Sbjct: 57 GLAIDSTVDIFT--FYV-PHRHVYGEQW---IKFMKDGVNA-------TPLPTVNTTGYI 103 Query: 226 DIPALNGLVD 235 D A G ++ Sbjct: 104 DHAAFLGTIN 113 >3EBV-A nrPDB Length = 302 Score = 29.6 bits (65), Expect = 3.1, Method: Compositional matrix adjust. Identities = 15/52 (28%), Positives = 24/52 (46%), Gaps = 10/52 (19%) Query: 98 KVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDLVKTYGFDGLDL 149 KV++SVGG+ + F S Y +++ YGFDG+D+ Sbjct: 77 KVIISVGGEKGT----------VSVNSSASATNFANSVYSVMREYGFDGVDI 118 >5Z7H-A nrPDB Length = 288 Score = 29.3 bits (64), Expect = 4.0, Method: Compositional matrix adjust. Identities = 20/73 (27%), Positives = 37/73 (50%), Gaps = 11/73 (15%) Query: 86 EVTSL-KRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDLVKTYGF 144 EV SL ++P++++ + VG I +H + ++ + G KV +L T+ F Sbjct: 108 EVLSLYNAQFPNVEIQVQVGSTEQIKANHRDYHVMITRGNKV---------MNLANTHLF 158 Query: 145 DGLDLAYQFPKNK 157 + D + FPKN+ Sbjct: 159 ND-DHYFIFPKNR 170 >1GKM-A nrPDB Length = 509 Score = 28.9 bits (63), Expect = 4.9, Method: Compositional matrix adjust. Identities = 36/141 (25%), Positives = 58/141 (41%), Gaps = 24/141 (17%) Query: 21 ASNLVCYYDSSSYTRE-------GLGKLLNPDLE--IALQFCSHLVYGYAGLRGENLQAY 71 AS + +D + R G+G L+ DL I + + L G++G+R + + A Sbjct: 63 ASTRIASHDLENLQRSLVLSHAAGIGAPLDDDLVRLIMVLKINSLSRGFSGIRRKVIDAL 122 Query: 72 SMNENLDIYKHQFSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGF 131 N ++Y PH+ + SVG D+ P + L EG K R G Sbjct: 123 IALVNAEVY--------------PHIPLKGSVGASGDLAPLAHMSLVLLGEG-KARYKGQ 167 Query: 132 IRSAYDLVKTYGFDGLDLAYQ 152 SA + + G + L LA + Sbjct: 168 WLSATEALAVAGLEPLTLAAK 188 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 1JNE-A nrPDB 512 e-146 5XEP-A nrPDB 396 e-110 1WB0-A nrPDB 396 e-110 4WKA-A nrPDB 391 e-109 1HJW-A nrPDB 389 e-108 3RM8-A nrPDB 384 e-107 5WV8-A nrPDB 380 e-106 5WUS-A nrPDB 376 e-104 2QF8-A nrPDB 371 e-103 3W4R-A nrPDB 368 e-102 4P8U-A nrPDB 361 e-100 5Y29-A nrPDB 359 1e-99 3WKZ-A nrPDB 358 3e-99 1E9L-A nrPDB 350 8e-97 5Y2C-A nrPDB 349 9e-97 6G9C-A nrPDB 335 2e-92 6BT9-A nrPDB 293 1e-79 1ITX-A nrPDB 280 7e-76 3CHF-A nrPDB 277 1e-74 5GQB-A nrPDB 266 2e-71 3G6L-A nrPDB 265 3e-71 5ZL9-A nrPDB 260 6e-70 5GZU-A nrPDB 258 4e-69 3ALF-A nrPDB 256 1e-68 6EPB-A nrPDB 256 1e-68 5Z7M-A nrPDB 256 1e-68 5DF0-A nrPDB 253 7e-68 3ARQ-A nrPDB 250 6e-67 3QOK-A nrPDB 248 2e-66 1LL6-A nrPDB 248 3e-66 6F8N-A nrPDB 247 7e-66 3AQU-A nrPDB 246 1e-65 4MNK-A nrPDB 245 3e-65 3WD0-A nrPDB 242 3e-64 4TXG-A nrPDB 230 1e-60 4URI-A nrPDB 227 7e-60 4W5U-B nrPDB 211 5e-55 1KFW-A nrPDB 205 3e-53 5XWF-A nrPDB 192 3e-49 Sequences not found previously or not previously below threshold: 4A5Q-A nrPDB 148 4e-36 4DWS-C nrPDB 143 1e-34 6OGD-C nrPDB 142 4e-34 4Q6T-A nrPDB 88 6e-18 4WIW-A nrPDB 86 3e-17 3CZ8-A nrPDB 82 5e-16 3CO4-A nrPDB 73 3e-13 4S3K-A nrPDB 69 3e-12 5JH8-A nrPDB 68 1e-11 4S3J-A nrPDB 66 4e-11 3SIM-A nrPDB 56 2e-08 4RL3-A nrPDB 54 2e-07 4TX8-A nrPDB 49 3e-06 1NAR-A nrPDB 48 6e-06 3EBV-A nrPDB 48 1e-05 2Y8V-A nrPDB 46 3e-05 4W5Z-A nrPDB 46 3e-05 3BXW-B nrPDB 45 5e-05 4MB4-A nrPDB 45 8e-05 3IAN-A nrPDB 43 4e-04 3N18-A nrPDB 42 5e-04 1EDT-A nrPDB 39 0.004 4AXN-A nrPDB 38 0.006 1EOM-A nrPDB 36 0.045 2EBN-A nrPDB 34 0.11 5M99-B nrPDB 33 0.24 6MDV-A nrPDB 32 0.54 6Q64-A nrPDB 32 0.58 1TZ7-A nrPDB 32 0.60 2GSJ-A nrPDB 32 0.66 3MAN-A nrPDB 31 1.0 4A1O-A nrPDB 31 1.0 4NUY-A nrPDB 31 1.3 3V6B-R nrPDB 30 2.1 3V2A-R nrPDB 30 2.1 3S35-X nrPDB 30 2.1 2X1X-R nrPDB 30 2.1 1YTQ-A nrPDB 30 2.3 3VLI-A nrPDB 30 2.6 1LFW-A nrPDB 30 2.7 3U37-A nrPDB 29 2.8 3HA9-A nrPDB 29 3.1 1F8Q-A nrPDB 29 3.2 4E2O-A nrPDB 29 4.1 2X1I-A nrPDB 29 4.4 4TOQ-A nrPDB 29 4.5 1OM0-A nrPDB 29 4.5 6FOP-A nrPDB 29 5.9 2D3L-A nrPDB 28 7.1 2VY0-A nrPDB 28 9.9 >1JNE-A nrPDB Length = 420 Score = 512 bits (1319), Expect = e-146, Method: Composition-based stats. Identities = 419/420 (99%), Positives = 420/420 (100%) Query: 21 ASNLVCYYDSSSYTREGLGKLLNPDLEIALQFCSHLVYGYAGLRGENLQAYSMNENLDIY 80 ASNLVCYYDSSSYTREGLGKLLNPDLEIALQFCSHLVYGYAGLRGENLQAYSMNENLDIY Sbjct: 1 ASNLVCYYDSSSYTREGLGKLLNPDLEIALQFCSHLVYGYAGLRGENLQAYSMNENLDIY 60 Query: 81 KHQFSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDLVK 140 KHQFSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAY+LVK Sbjct: 61 KHQFSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYELVK 120 Query: 141 TYGFDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTALVRDV 200 TYGFDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTALVRDV Sbjct: 121 TYGFDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTALVRDV 180 Query: 201 KDSLRADGFLLSLTVLPNVNSTWYFDIPALNGLVDFVNLATFDFLTPARNPEEADYSAPI 260 KDSLRADGFLLSLTVLPNVNSTWYFDIPALNGLVDFVNLATFDFLTPARNPEEADYSAPI Sbjct: 181 KDSLRADGFLLSLTVLPNVNSTWYFDIPALNGLVDFVNLATFDFLTPARNPEEADYSAPI 240 Query: 261 YHPDGSKDRLAHLNADFQVEYWLSQGFPSNKINLGVATYGNAWKLTKDSGLEGVPVVPET 320 YHPDGSKDRLAHLNADFQVEYWLSQGFPSNKINLGVATYGNAWKLTKDSGLEGVPVVPET Sbjct: 241 YHPDGSKDRLAHLNADFQVEYWLSQGFPSNKINLGVATYGNAWKLTKDSGLEGVPVVPET 300 Query: 321 SGPAPEGFQSQKPGLLSYAEICGKLSNPQNQFLKGNESPLRRVSDPTKRFGGIAYRPVDG 380 SGPAPEGFQSQKPGLLSYAEICGKLSNPQNQFLKGNESPLRRVSDPTKRFGGIAYRPVDG Sbjct: 301 SGPAPEGFQSQKPGLLSYAEICGKLSNPQNQFLKGNESPLRRVSDPTKRFGGIAYRPVDG 360 Query: 381 QITEGIWVSYDDPDSASNKAAYARVKNLGGVALFDLSYDDFRGQCSGDKYPILRAIKYRL 440 QITEGIWVSYDDPDSASNKAAYARVKNLGGVALFDLSYDDFRGQCSGDKYPILRAIKYRL Sbjct: 361 QITEGIWVSYDDPDSASNKAAYARVKNLGGVALFDLSYDDFRGQCSGDKYPILRAIKYRL 420 >5XEP-A nrPDB Length = 381 Score = 396 bits (1016), Expect = e-110, Method: Composition-based stats. Identities = 111/437 (25%), Positives = 189/437 (43%), Gaps = 66/437 (15%) Query: 7 FTFVACLFAASTEAASNLVCYYDSSSYTREGLGKLLNPDLEIALQFCSHLVYGYAGLRGE 66 T A L + +A LVCY+ S S REG+G L ++ L C+H++Y +A + + Sbjct: 7 LTGFAVLMLLQSCSAYKLVCYFTSWSQYREGVGSFLPDAIQPFL--CTHIIYSFANISSD 64 Query: 67 N-LQAYSMNENLDIYKHQFSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEK 125 N L + N+ + + ++ LK + +LK LLSVGG K + Sbjct: 65 NMLSTWEWND-----ESNYDKLNKLKTRNTNLKTLLSVGGW-----KFGGKRFSEIASNT 114 Query: 126 VRQIGFIRSAYDLVKTYGFDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPH 185 R+ F+RS +++YGFDGLDLA+ +P+ + ++ L Sbjct: 115 ERRTAFVRSVAPFLRSYGFDGLDLAWLYPRLRDKQYFSTLIKELN--------------- 159 Query: 186 AALHKEQFTALVRDVKDSLRADGFLLSLTVLPNVNSTW-YFDIPALNGLVDFVNLATFDF 244 +FT V+ ++ L LLS + + +DI + +DF+NL T+DF Sbjct: 160 -----AEFTKEVQPGREKL-----LLSAALSAGKVAIDTGYDIAQIAQHLDFINLMTYDF 209 Query: 245 LTPARNPEEADYSAPIYHPDGSKDRLAHLNADFQVEYWLSQGFPSNKINLGVATYGNAWK 304 R + + +P++ + N ++ V+Y + G ++K+ +G+ T+G ++ Sbjct: 210 HGVWR--QITGHHSPLFQGQKDTRFDRYSNVNYAVQYMIRLGAQASKLLMGIPTFGKSFT 267 Query: 305 LTKDSGLEGVPVVPETSGPAPEGFQSQKPGLLSYAEICGKLSNPQNQFLKGNESPLRRVS 364 L G P+ SG G +++ G L+Y EIC L + L + P Sbjct: 268 LASSENQLGAPI----SGEGLPGRFTKEAGTLAYYEICDFLKGAEVHRLSNEKVPFAT-- 321 Query: 365 DPTKRFGGIAYRPVDGQITEGIWVSYDDPDSASNKAAYARVKNLGGVALFDLSYDDFRGQ 424 WV Y+D +S NK + + K L G ++ L DDF+G Sbjct: 322 ------------------KGNQWVGYEDKESVKNKVRFLKEKKLAGAMVWALDLDDFQGT 363 Query: 425 CSGDK-YPILRAIKYRL 440 C + +P+ AIK L Sbjct: 364 CQPKEFFPLTNAIKDAL 380 >1WB0-A nrPDB Length = 445 Score = 396 bits (1016), Expect = e-110, Method: Composition-based stats. Identities = 111/428 (25%), Positives = 192/428 (44%), Gaps = 73/428 (17%) Query: 22 SNLVCYYDSSSYTREGLGKLLNPDLEIALQFCSHLVYGYAGLRGENLQAYSMNENLDIYK 81 + LVCY+ + + R+G + L DL+ +L C+HL+Y +AG+ L N+ + Sbjct: 1 AKLVCYFTNWAQYRQGEARFLPKDLDPSL--CTHLIYAFAGMTNHQLSTTEWND-----E 53 Query: 82 HQFSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDLVKT 141 + E LK+ P LK LL++GG + K+ D++ RQ F+ SA ++ Sbjct: 54 TLYQEFNGLKKMNPKLKTLLAIGGWNF----GTQKFTDMVATANNRQT-FVNSAIRFLRK 108 Query: 142 YGFDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTALVRDVK 201 Y FDGLDL +++P ++ A+ KE+FT LV+D+ Sbjct: 109 YSFDGLDLDWEYPGSQ--------------------------GSPAVDKERFTTLVQDLA 142 Query: 202 DSLRADG-------FLLSLTVLPNVNSTW-YFDIPALNGLVDFVNLATFDFLTPARNPEE 253 ++ + + LLS V +++ + +DFVNL +DF + Sbjct: 143 NAFQQEAQTSGKERLLLSAAVPAGQTYVDAGYEVDKIAQNLDFVNLMAYDFHGSWE--KV 200 Query: 254 ADYSAPIYHPDGSKDRLAHLNADFQVEYWLSQGFPSNKINLGVATYGNAWKLTKDSGLEG 313 +++P+Y A LN D V+ WL +G P++K+ LG+ TYG ++ L S Sbjct: 201 TGHNSPLYKRQEESGAAASLNVDAAVQQWLQKGTPASKLILGMPTYGRSFTLASSSDT-- 258 Query: 314 VPVVPETSGPAPEGFQSQKPGLLSYAEICGKLSNPQNQFLKGNESPLRRVSDPTKRFGGI 373 V +G G +++ G+L+Y E+C Q ++ + P Sbjct: 259 -RVGAPATGSGTPGPFTKEGGMLAYYEVCSW-KGATKQRIQDQKVP-------------- 302 Query: 374 AYRPVDGQITEGIWVSYDDPDSASNKAAYARVKNLGGVALFDLSYDDFRG-QCSGDKYPI 432 + WV +DD +S K +Y + K LGG ++ L DDF G C+ +YP+ Sbjct: 303 ------YIFRDNQWVGFDDVESFKTKVSYLKQKGLGGAMVWALDLDDFAGFSCNQGRYPL 356 Query: 433 LRAIKYRL 440 ++ ++ L Sbjct: 357 IQTLRQEL 364 >4WKA-A nrPDB Length = 377 Score = 391 bits (1005), Expect = e-109, Method: Composition-based stats. Identities = 111/428 (25%), Positives = 192/428 (44%), Gaps = 73/428 (17%) Query: 22 SNLVCYYDSSSYTREGLGKLLNPDLEIALQFCSHLVYGYAGLRGENLQAYSMNENLDIYK 81 + LVCY+ + + R+G + L DL+ +L C+HL+Y +AG+ L N+ + Sbjct: 1 AKLVCYFTNWAQYRQGEARFLPKDLDPSL--CTHLIYAFAGMTNHQLSTTEWND-----E 53 Query: 82 HQFSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDLVKT 141 + E LK+ P LK LL++GG + K+ D++ RQ F+ SA ++ Sbjct: 54 TLYQEFNGLKKMNPKLKTLLAIGGWNF----GTQKFTDMVATANNRQT-FVNSAIRFLRK 108 Query: 142 YGFDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTALVRDVK 201 Y FDGLDL +++P ++ A+ KE+FT LV+D+ Sbjct: 109 YSFDGLDLDWEYPGSQ--------------------------GSPAVDKERFTTLVQDLA 142 Query: 202 DSLRADG-------FLLSLTVLPNVNSTW-YFDIPALNGLVDFVNLATFDFLTPARNPEE 253 ++ + + LLS V +++ + +DFVNL +DF + Sbjct: 143 NAFQQEAQTSGKERLLLSAAVPAGQTYVDAGYEVDKIAQNLDFVNLMAYDFHGSWE--KV 200 Query: 254 ADYSAPIYHPDGSKDRLAHLNADFQVEYWLSQGFPSNKINLGVATYGNAWKLTKDSGLEG 313 +++P+Y A LN D V+ WL +G P++K+ LG+ TYG ++ L S Sbjct: 201 TGHNSPLYKRQEESGAAASLNVDAAVQQWLQKGTPASKLILGMPTYGRSFTLASSSDT-- 258 Query: 314 VPVVPETSGPAPEGFQSQKPGLLSYAEICGKLSNPQNQFLKGNESPLRRVSDPTKRFGGI 373 V +G G +++ G+L+Y E+C Q ++ + P Sbjct: 259 -RVGAPATGSGTPGPFTKEGGMLAYYEVCSW-KGATKQRIQDQKVP-------------- 302 Query: 374 AYRPVDGQITEGIWVSYDDPDSASNKAAYARVKNLGGVALFDLSYDDFRG-QCSGDKYPI 432 + WV +DD +S K +Y + K LGG ++ L DDF G C+ +YP+ Sbjct: 303 ------YIFRDNQWVGFDDVESFKTKVSYLKQKGLGGAMVWALDLDDFAGFSCNQGRYPL 356 Query: 433 LRAIKYRL 440 ++ ++ L Sbjct: 357 IQTLRQEL 364 >1HJW-A nrPDB Length = 362 Score = 389 bits (999), Expect = e-108, Method: Composition-based stats. Identities = 108/428 (25%), Positives = 183/428 (42%), Gaps = 78/428 (18%) Query: 22 SNLVCYYDSSSYTREGLGKLLNPDLEIALQFCSHLVYGYAGLRGENLQAYSMNENLDIYK 81 LVCYY S S REG G L+ L C+H++Y +A + +++ + N+ Sbjct: 1 YKLVCYYTSWSQYREGDGSCFPDALDRFL--CTHIIYSFANISNDHIDTWEWNDV----- 53 Query: 82 HQFSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDLVKT 141 + + +LK + P+LK LLSVGG + ++ + + R+ FI+S ++T Sbjct: 54 TLYGMLNTLKNRNPNLKTLLSVGGWNF----GSQRFSKIASNTQSRRT-FIKSVPPFLRT 108 Query: 142 YGFDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTALVRDVK 201 +GFDGLDLA+ +P + K+ FT L++++K Sbjct: 109 HGFDGLDLAWLYPGRR-------------------------------DKQHFTTLIKEMK 137 Query: 202 DSLRADG------FLLSLTVLPNVNSTW-YFDIPALNGLVDFVNLATFDFLTPARNPEEA 254 + LLS + + +DI ++ +DF+++ T+DF R Sbjct: 138 AEFIKEAQPGKKQLLLSAALSAGKVTIDSSYDIAKISQHLDFISIMTYDFHGAWRG--TT 195 Query: 255 DYSAPIYHPDGSKDRLAHLNADFQVEYWLSQGFPSNKINLGVATYGNAWKLTKDSGLEGV 314 + +P++ N D+ V Y L G P++K+ +G+ T+G ++ L G Sbjct: 196 GHHSPLFRGQEDASPDRFSNTDYAVGYMLRLGAPASKLVMGIPTFGRSFTLASSETGVGA 255 Query: 315 PVVPETSGPAPEGFQSQKPGLLSYAEICGKLSNPQNQFLKGNESPLRRVSDPTKRFGGIA 374 P+ SGP G +++ G L+Y EIC L + G + P Sbjct: 256 PI----SGPGIPGRFTKEAGTLAYYEICDFLRGATVHRILGQQVP--------------- 296 Query: 375 YRPVDGQITEGIWVSYDDPDSASNKAAYARVKNLGGVALFDLSYDDFRGQCSGD--KYPI 432 WV YDD +S +K Y + + L G ++ L DDF+G G ++P+ Sbjct: 297 -----YATKGNQWVGYDDQESVKSKVQYLKDRQLAGAMVWALDLDDFQGSFCGQDLRFPL 351 Query: 433 LRAIKYRL 440 AIK L Sbjct: 352 TNAIKDAL 359 >3RM8-A nrPDB Length = 395 Score = 384 bits (986), Expect = e-107, Method: Composition-based stats. Identities = 99/428 (23%), Positives = 181/428 (42%), Gaps = 71/428 (16%) Query: 22 SNLVCYYDSSSYTREGLGKLLNPDLEIALQFCSHLVYGYAGLRGENLQAYSMNENLDIYK 81 L CY+ + + R GLG+ + D+ L C+HL+Y +AG++ + N+ Sbjct: 1 YQLTCYFTNWAQYRPGLGRFMPDDINPCL--CTHLIYAFAGMQNNEITTIEWNDV----- 53 Query: 82 HQFSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDLVKT 141 + LK K LK LL++GG + + ++ + RQ FI S ++ Sbjct: 54 TLYQAFNGLKNKNSQLKTLLAIGGWNF----GTAPFTAMVSTPENRQT-FITSVIKFLRQ 108 Query: 142 YGFDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTALVRDVK 201 Y FDGLD +++P ++ K FT LV++++ Sbjct: 109 YEFDGLDFDWEYPGSR--------------------------GSPPQDKHLFTVLVQEMR 142 Query: 202 DSLRADG-------FLLSLTVLPNVNSTW-YFDIPALNGLVDFVNLATFDFLTPARNPEE 253 ++ + +++ V +++ ++IP L+ +D++++ T+D Sbjct: 143 EAFEQEAKQINKPRLMVTAAVAAGISNIQSGYEIPQLSQYLDYIHVMTYDLHGSWEG--Y 200 Query: 254 ADYSAPIYHPDGSKDRLAHLNADFQVEYWLSQGFPSNKINLGVATYGNAWKLTKDSGLEG 313 ++P+Y A+LN D+ + YW G P+ K+ +G TYG+ + L+ S Sbjct: 201 TGENSPLYKYPTDTGSNAYLNVDYVMNYWKDNGAPAEKLIVGFPTYGHNFILSNPSNTG- 259 Query: 314 VPVVPETSGPAPEGFQSQKPGLLSYAEICGKLSNPQNQFLKGNESPLRRVSDPTKRFGGI 373 + TSG P G +++ G+ +Y EIC L N T+ + Sbjct: 260 --IGAPTSGAGPAGPYAKESGIWAYYEICTFLKNG-----------------ATQGWDAP 300 Query: 374 AYRPVDGQITEGIWVSYDDPDSASNKAAYARVKNLGGVALFDLSYDDFRGQ-CSGDKYPI 432 P Q +WV YD+ S KA + + GG ++ + DDF G C+ K+P+ Sbjct: 301 QEVPYAYQ--GNVWVGYDNVKSFDIKAQWLKHNKFGGAMVWAIDLDDFTGTFCNQGKFPL 358 Query: 433 LRAIKYRL 440 + +K L Sbjct: 359 ISTLKKAL 366 >5WV8-A nrPDB Length = 482 Score = 380 bits (975), Expect = e-106, Method: Composition-based stats. Identities = 102/430 (23%), Positives = 180/430 (41%), Gaps = 72/430 (16%) Query: 22 SNLVCYYDSSSYTREGLGKLLNPDLEIALQFCSHLVYGYAGLRGENLQAYSMNE-NLDIY 80 +VCYY + S R +GK + D++ + C+H+++ + L+ L ++ N+ D Sbjct: 93 YKIVCYYTNWSQYRTKIGKFMPEDIQP--ELCTHIIFAFGWLKKGKLSSFESNDETKDGK 150 Query: 81 KHQFSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDLVK 140 + + +LK+ P LK LL++GG K+ ++ RQ FI SA ++ Sbjct: 151 TGLYDRINALKKANPKLKTLLAIGGWSF----GTQKFKEMSATRYARQT-FIYSAIPYLR 205 Query: 141 TYGFDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTALVRDV 200 FDGLD+ + +PK K+ + L++++ Sbjct: 206 DRNFDGLDIDWLYPKGGD------------------------------DKKNYVLLLKEL 235 Query: 201 KDSLRADG-------FLLSLTVLPNVNSTW-YFDIPALNGLVDFVNLATFDFLTPARNPE 252 +++ A+ LL+ V ++ +D+PA+ +DF+NL +DF Sbjct: 236 REAFEAEAQEVKKPRLLLTAAVPVGPDNIKSGYDVPAVASYLDFINLMAYDFHGKWE--R 293 Query: 253 EADYSAPIYHPDGSKDRLAHLNADFQVEYWLSQGFPSNKINLGVATYGNAWKLTKDSGLE 312 E ++AP+Y P + L+ D W+ G P K+ +G+ TYG + L+ + Sbjct: 294 ETGHNAPLYAPSSDSEWRKQLSVDHAAHLWVKLGAPKEKLIIGMPTYGRTFTLSNPNNF- 352 Query: 313 GVPVVPETSGPAPEGFQSQKPGLLSYAEICGKLSNPQNQFLKGNESPLRRVSDPTKRFGG 372 V SG G +++ G L+Y E+C L N V D + Sbjct: 353 --KVNSPASGGGKAGEYTKESGFLAYYEVCEILRNGG-----------AYVWDDEMKVP- 398 Query: 373 IAYRPVDGQITEGIWVSYDDPDSASNKAAYARVKNLGGVALFDLSYDDFRGQCSGD--KY 430 I WV +DD S NK + + + GG ++ + DDF G G KY Sbjct: 399 -------YAIHGDQWVGFDDEKSIRNKMRWIKDNSFGGAMVWTVDMDDFSGGVCGGNVKY 451 Query: 431 PILRAIKYRL 440 P++ A++ L Sbjct: 452 PLIGAMREEL 461 >5WUS-A nrPDB Length = 460 Score = 376 bits (964), Expect = e-104, Method: Composition-based stats. Identities = 96/426 (22%), Positives = 184/426 (43%), Gaps = 73/426 (17%) Query: 23 NLVCYYDSSSYTREGLGKLLNPDLEIALQFCSHLVYGYAGLRGENLQAYSMNENLDIYKH 82 ++CY S S R G+ + +++ L C+H++Y +A L+ L + ++ D+Y Sbjct: 3 QVLCYLTSWSSKRPSAGRFMPENVDPTL--CTHVIYAFATLKDHKLTE-ADEKDADMY-- 57 Query: 83 QFSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDLVKTY 142 +V +L+ K P+LK+LL++GG + L R F+ A + ++ Y Sbjct: 58 --DKVVALREKNPNLKILLAIGGW-----AFGSTPFKELTSNVFRMNQFVYEAIEFLRDY 110 Query: 143 GFDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTALVRDVKD 202 F+GLD+ +++P+ + F +L+++++ Sbjct: 111 QFNGLDVDWEYPRGAD------------------------------DRAAFVSLLKELRL 140 Query: 203 SLRADG-------FLLSLTVLPNVNSTW-YFDIPALNGLVDFVNLATFDFLTPARNPEEA 254 + + LL+ V + + +D+P ++ +DF+N+ T+DF + Sbjct: 141 AFEGEAKTSGQPRLLLTAAVPASFEAIAAGYDVPEISKYLDFINVMTYDFHGQWE--RQV 198 Query: 255 DYSAPIYHPDGSKDRLAHLNADFQVEYWLSQGFPSNKINLGVATYGNAWKLTKDSGLEGV 314 +++P++ + + L D+ W+ QG P K+ +G+ TYG ++ L D+ + Sbjct: 199 GHNSPLFPLESATSYQKKLTVDYSAREWVRQGAPKEKLMIGMPTYGRSFTLINDTQFD-- 256 Query: 315 PVVPETSGPAPEGFQSQKPGLLSYAEICGKLSNPQNQFLKGNESPLRRVSDPTKRFGGIA 374 + SG G + + G +SY EIC L + NE + Sbjct: 257 -IGAPASGGGQAGRFTNEAGFMSYYEICEFLREDNTTLVWDNEQMVPFAY---------- 305 Query: 375 YRPVDGQITEGIWVSYDDPDSASNKAAYARVKNLGGVALFDLSYDDFRGQCSGDKYPILR 434 E WV +DD S K A+ + + GG+ ++ + DDFRG C KYP++ Sbjct: 306 --------REDQWVGFDDERSLKTKMAWLKEEGFGGIMVWSVDMDDFRGSCGTGKYPLIT 357 Query: 435 AIKYRL 440 A+K L Sbjct: 358 AMKQEL 363 >2QF8-A nrPDB Length = 361 Score = 371 bits (953), Expect = e-103, Method: Composition-based stats. Identities = 116/423 (27%), Positives = 188/423 (44%), Gaps = 69/423 (16%) Query: 22 SNLVCYYDSSSYTREGLGKLLNPDLEIALQFCSHLVYGYAGLRGENLQAYSMNENLDIYK 81 L+CYY S S REG G ++ L C+H++Y +A + + + N+ Sbjct: 1 YKLICYYTSWSQYREGDGSCFPDAIDPFL--CTHVIYSFANISNNEIDTWEWNDV----- 53 Query: 82 HQFSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDLVKT 141 + + +LK + P+LK LLSVGG + ++ + + R+ FI+S ++T Sbjct: 54 TLYDTLNTLKNRNPNLKTLLSVGGWNY----GSQRFSKIASKTQSRRT-FIKSVPPFLRT 108 Query: 142 YGFDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTALVRDVK 201 +GFDGLDLA+ +P W+ + L L KE VR+ + Sbjct: 109 HGFDGLDLAWLWPG-------------WRDKRHLT----------TLVKEMKAEFVREAQ 145 Query: 202 DSLRADGFLLSLTVLPNVNSTW-YFDIPALNGLVDFVNLATFDFLTPARNPEEADYSAPI 260 + LLS V + +DI ++ +DF++L T+DF R + + +P+ Sbjct: 146 A--GTEQLLLSAAVTAGKIAIDRGYDIAQISRHLDFISLLTYDFHGAWR--QTVGHHSPL 201 Query: 261 YHPDGSKDRLAHL-NADFQVEYWLSQGFPSNKINLGVATYGNAWKLTKDSGLEGVPVVPE 319 + G++D + NAD+ V Y L G P+NK+ +G+ T+G ++ L G P+ Sbjct: 202 FR--GNEDASSRFSNADYAVSYMLRLGAPANKLVMGIPTFGRSYTLASSKTDVGAPI--- 256 Query: 320 TSGPAPEGFQSQKPGLLSYAEICGKLSNPQNQFLKGNESPLRRVSDPTKRFGGIAYRPVD 379 SGP G ++ G+L+Y EIC L + + P Sbjct: 257 -SGPGIPGRFTKWKGILAYYEICDFLHGATTHRFRDQQVP-------------------- 295 Query: 380 GQITEGIWVSYDDPDSASNKAAYARVKNLGGVALFDLSYDDFRGQCSGDK--YPILRAIK 437 WV+YDD +S NKA Y + + L G ++ L DDFRG G +P+ AIK Sbjct: 296 YATKGNQWVAYDDQESVKNKARYLKNRQLAGAMVWALDLDDFRGTFCGQNLTFPLTSAIK 355 Query: 438 YRL 440 L Sbjct: 356 DVL 358 >3W4R-A nrPDB Length = 554 Score = 368 bits (944), Expect = e-102, Method: Composition-based stats. Identities = 100/431 (23%), Positives = 191/431 (44%), Gaps = 56/431 (12%) Query: 15 AASTEAASNLVCYYDSSSYTREGLGKLLNPDLEIALQFCSHLVYGYAGLRGENLQAYSMN 74 AA +++ + +VCY+ + + R G+G+ D I + C+H++Y + G+ + Q ++ Sbjct: 18 AAESDSRARVVCYFSNWAVYRPGVGRYGIED--IPVDMCTHIIYSFIGVTEDTQQVLIID 75 Query: 75 ENLDIYKHQFSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRS 134 LD+ K+ F TSL+ K+P +K ++VGG + +KY ++ + R + F+RS Sbjct: 76 PELDVDKNGFKNFTSLRSKHPGVKFTVAVGGWA----EGGSKYSKMVAAKSTR-MAFVRS 130 Query: 135 AYDLVKTYGFDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFT 194 D + Y FDGLDL +++P R K++F Sbjct: 131 VVDFLNKYNFDGLDLDWEYPGAADRGGSFS------------------------DKDKFL 166 Query: 195 ALVRDVKDSL--RADGFLLSLTVL-PNVNSTWYFDIPALNGLVDFVNLATFDFLTPARNP 251 LV++++ + G+ L+ V N + +P L +D +++ ++D Sbjct: 167 YLVQELRRAFIREGKGWELTAAVPLANFRLMEGYHVPELCQELDAIHVMSYDLRGNWAGF 226 Query: 252 EEADYSAPIYHPDGSKDRLAHLNADFQVEYWLSQGFPSNKINLGVATYGNAWKLTKDSGL 311 AD +P+Y + LN + ++ W +G P+NK+ +G+ YG ++ L+ + Sbjct: 227 --ADVHSPLYKRPHDQWAYEKLNVNDGLQLWEDKGCPTNKLVVGIPFYGRSFTLSSGNNN 284 Query: 312 E--GVPVVPETSGPAPEGFQSQKPGLLSYAEICGKLSNPQNQFLKGNESPLRRVSDPTKR 369 G + E G P + G +Y EIC ++ ++ TK+ Sbjct: 285 YNLGTYINKEAGGGDPA-PYTNATGFWAYYEICTEVDTADSK--------------WTKK 329 Query: 370 FGGIAYRPVDGQITEGIWVSYDDPDSASNKAAYARVKNLGGVALFDLSYDDFRGQCSGDK 429 + P + T WV Y+DP S K + + K G + + DDF+G C G+K Sbjct: 330 WDEHGKCPYAYKGT--QWVGYEDPRSVEIKMNWIKEKGYLGAMTWAIDMDDFQGLC-GEK 386 Query: 430 YPILRAIKYRL 440 +++ + + Sbjct: 387 NILIKLLHKHM 397 >4P8U-A nrPDB Length = 371 Score = 361 bits (925), Expect = e-100, Method: Composition-based stats. Identities = 105/429 (24%), Positives = 181/429 (42%), Gaps = 76/429 (17%) Query: 21 ASNLVCYYDSSSYTREGLGKLLNPDLEIALQFCSHLVYGYAGLRGENLQAYSMNENLDIY 80 + LVCY+ + S R+ GK +++ L CSHL+Y +A + + +E + Sbjct: 7 SYKLVCYFTNWSQDRQEPGKFTPENIDPFL--CSHLIYSFASIENNKVIIKDKSEVM--- 61 Query: 81 KHQFSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDLVK 140 + + SLK K P LK+LLS+GG +K + ++ FI S ++ Sbjct: 62 --LYQTINSLKTKNPKLKILLSIGGYL-----FGSKGFHPMVDSSTSRLEFINSIILFLR 114 Query: 141 TYGFDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTALVRDV 200 + FDGLD+++ +P K FT L+ ++ Sbjct: 115 NHNFDGLDVSWIYPDQK-------------------------------ENTHFTVLIHEL 143 Query: 201 KDSLRAD-------GFLLSLTVLPNVNSTW-YFDIPALNGLVDFVNLATFDFLTPARNPE 252 ++ + D LL++ V + + L +DF+NL +FDF P Sbjct: 144 AEAFQKDFTKSTKERLLLTVGVSAGRQMIDNSYQVEKLAKDLDFINLLSFDFHGSWEKPL 203 Query: 253 EADYSAPIYHPDGSKDRLAHLNADFQVEYWLSQGFPSNKINLGVATYGNAWKLTKDSGLE 312 +++P+ + ++ N ++ V YW+ +G PS K+ +G+ TYG+++ L Sbjct: 204 ITGHNSPLSKGWQDRGPSSYYNVEYAVGYWIHKGMPSEKVVMGIPTYGHSFTLASAETTV 263 Query: 313 GVPVVPETSGPAPEGFQSQKPGLLSYAEICGKLSNPQNQFLKGNESPLRRVSDPTKRFGG 372 G P SGP G ++ G L+Y EIC L + +L+ + P Sbjct: 264 GAP----ASGPGAAGPITESSGFLAYYEICQFLKGAKITWLQDQQVP------------- 306 Query: 373 IAYRPVDGQITEGIWVSYDDPDSASNKAAYARVKNLGGVALFDLSYDDFRG-QCSGDKYP 431 + WV YDD S K + + NLGG ++ + DDF G C+ YP Sbjct: 307 -------YAVKGNQWVGYDDVKSMETKVQFLKNLNLGGAMIWSIDMDDFTGKSCNQGPYP 359 Query: 432 ILRAIKYRL 440 +++A+K L Sbjct: 360 LVQAVKRSL 368 >5Y29-A nrPDB Length = 377 Score = 359 bits (921), Expect = 1e-99, Method: Composition-based stats. Identities = 121/423 (28%), Positives = 201/423 (47%), Gaps = 55/423 (13%) Query: 19 EAASNLVCYYDSSSYTREGLGKLLNPDLEIALQFCSHLVYGYAGLRGENLQAYSMNENLD 78 + LVCYY + S+ R G+GK D++ +L C+H+VYG+A L + L + + D Sbjct: 4 NSRYKLVCYYTNWSWYRPGIGKYSPEDIDPSL--CTHIVYGFAVLGNDGLMT-AHDTWSD 60 Query: 79 IYKHQFSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDL 138 + V KR +KV L++GG +D +KY L+ R F++ A Sbjct: 61 YDNRFYERVVEYKRY--GIKVSLALGGWNDS---AGDKYSKLVNDPAARA-KFVQHAVAF 114 Query: 139 VKTYGFDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTALVR 198 ++ YGFDGLDL +++PK K+ F LV Sbjct: 115 LEKYGFDGLDLDWEYPK---------------------CWQVDCSKGPDSDKQGFADLVH 153 Query: 199 DVKDSLRADGFLLSLTVLPNVNSTW-YFDIPALNGLVDFVNLATFDFLTPARNPEEADYS 257 ++ L+ G LLS V PN +D+P L L+D++ + T+D+ + ++ + Sbjct: 154 ELSAVLKPKGLLLSAAVSPNKMVIDAGYDVPVLARLLDWIAVMTYDYHG--QWDKKTGHV 211 Query: 258 APIYHPDGSKDRLAHLNADFQVEYWLSQGFPSNKINLGVATYGNAWKLTKDSGLEGVPVV 317 AP+Y+ D + NA++ + YW+ +G P++KI +G+ YG ++ + ++ G+ G+ + Sbjct: 212 APLYYHPD--DDTTYFNANYTIHYWMEKGTPASKIVMGMPMYGQSFTI-ENRGIHGLNIP 268 Query: 318 PETSGPAPEGFQSQKPGLLSYAEICGKLSNPQNQFLKGNESPLRRVSDPTKRFGGIAYRP 377 G G ++ G L+Y EIC ++ N S V DP +R G AY+ Sbjct: 269 VSDGG--EPGEYTRAKGFLAYYEICDRIRN----------SGWTVVKDPYQRMGPYAYK- 315 Query: 378 VDGQITEGIWVSYDDPDSASNKAAYARVKNLGGVALFDLSYDDFRGQCSGDKYPILRAIK 437 WVS+DD + K + + NLGG ++ L DD+R +C K+P+L AIK Sbjct: 316 ------GNQWVSFDDVEIIKKKVNFIKSLNLGGGMIWALDLDDYRNRCGQGKHPLLNAIK 369 Query: 438 YRL 440 L Sbjct: 370 TEL 372 >3WKZ-A nrPDB Length = 395 Score = 358 bits (918), Expect = 3e-99, Method: Composition-based stats. Identities = 100/430 (23%), Positives = 190/430 (44%), Gaps = 56/430 (13%) Query: 16 ASTEAASNLVCYYDSSSYTREGLGKLLNPDLEIALQFCSHLVYGYAGLRGENLQAYSMNE 75 A +++ + +VCY+ + + R G+G+ D I + C+H++Y + G+ + Q ++ Sbjct: 1 AESDSRARVVCYFSNWAVYRPGVGRYGIED--IPVDMCTHIIYSFIGVTEDTQQVLIIDP 58 Query: 76 NLDIYKHQFSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSA 135 LD+ K+ F TSL+ K+P +K ++VGG + +KY ++ + R + F+RS Sbjct: 59 ELDVDKNGFKNFTSLRSKHPGVKFTVAVGGWA----EGGSKYSKMVAAKSTR-MAFVRSV 113 Query: 136 YDLVKTYGFDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTA 195 D + Y FDGLDL +Q+P R K++F Sbjct: 114 VDFLNKYNFDGLDLDWQYPGAADRGGSFS------------------------DKDKFLY 149 Query: 196 LVRDVKDSL--RADGFLLSLTVL-PNVNSTWYFDIPALNGLVDFVNLATFDFLTPARNPE 252 LV++++ + G+ L+ V N + +P L +D +++ ++D Sbjct: 150 LVQELRRAFIREGKGWELTAAVPLANFRLMEGYHVPELCQELDAIHVMSYDLRGNWAGF- 208 Query: 253 EADYSAPIYHPDGSKDRLAHLNADFQVEYWLSQGFPSNKINLGVATYGNAWKLTKDSGLE 312 AD +P+Y + LN + ++ W +G P+NK+ +G+ YG ++ L+ + Sbjct: 209 -ADVHSPLYKRPHDQWAYEKLNVNDGLQLWEDKGCPTNKLVVGIPFYGRSFTLSSGNNNY 267 Query: 313 --GVPVVPETSGPAPEGFQSQKPGLLSYAEICGKLSNPQNQFLKGNESPLRRVSDPTKRF 370 G + E G P + G +Y EIC ++ ++ TK++ Sbjct: 268 NLGTYINKEAGGGDPA-PYTNATGFWAYYEICTEVDTADSK--------------WTKKW 312 Query: 371 GGIAYRPVDGQITEGIWVSYDDPDSASNKAAYARVKNLGGVALFDLSYDDFRGQCSGDKY 430 P + T WV Y+DP S K + + K G + + DDF+G C G+K Sbjct: 313 DEHGKCPYAYKGT--QWVGYEDPRSVEIKMNWIKEKGYLGAMTWAIDMDDFQGLC-GEKN 369 Query: 431 PILRAIKYRL 440 +++ + + Sbjct: 370 ILIKLLHKHM 379 >1E9L-A nrPDB Length = 377 Score = 350 bits (897), Expect = 8e-97, Method: Composition-based stats. Identities = 105/428 (24%), Positives = 179/428 (41%), Gaps = 71/428 (16%) Query: 22 SNLVCYYDSSSYTREGLGKLLNPDLEIALQFCSHLVYGYAGLRGENLQAYSMNENLDIYK 81 L+CYY S + R G +++ L C+HL+Y +AG++ + Y+ ++L Y+ Sbjct: 1 YQLMCYYTSWAKDRPIEGSFKPGNIDPCL--CTHLIYAFAGMQNNEI-TYTHEQDLRDYE 57 Query: 82 HQFSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDLVKT 141 + LK K LK LL++GG P + ++ + RQI FI+S ++ Sbjct: 58 ----ALNGLKDKNTELKTLLAIGGWKF----GPAPFSAMVSTPQNRQI-FIQSVIRFLRQ 108 Query: 142 YGFDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTALVRDVK 201 Y FDGL+L +Q+P ++ K F+ LV++++ Sbjct: 109 YNFDGLNLDWQYPGSR--------------------------GSPPKDKHLFSVLVKEMR 142 Query: 202 DSLRAD-------GFLLSLTVLPNVNSTW-YFDIPALNGLVDFVNLATFDFLTPARNPEE 253 + + LL+ T ++ + IP L+ +D++ + T+D P Sbjct: 143 KAFEEESVEKDIPRLLLTSTGAGIIDVIKSGYKIPELSQSLDYIQVMTYDLHDPKDG--Y 200 Query: 254 ADYSAPIYHPDGSKDRLAHLNADFQVEYWLSQGFPSNKINLGVATYGNAWKLTKDSGLEG 313 ++P+Y + A LN D + YW G S K+ +G YG+ + L D G Sbjct: 201 TGENSPLYKSPYDIGKSADLNVDSIISYWKDHGAASEKLIVGFPAYGHTFIL-SDPSKTG 259 Query: 314 VPVVPETSGPAPEGFQSQKPGLLSYAEICGKLSNPQNQFLKGNESPLRRVSDPTKRFGGI 373 + ++GP G + + GLL+Y E+C L+ T+ + Sbjct: 260 IGAPTISTGP--PGKYTDESGLLAYYEVCTFLNEG-----------------ATEVWDAP 300 Query: 374 AYRPVDGQITEGIWVSYDDPDSASNKAAYARVKNLGGVALFDLSYDDFRGQ-CSGDKYPI 432 P Q WV YD+ S KA + + NLGG ++ L DDF G C +P+ Sbjct: 301 QEVPYAYQ--GNEWVGYDNVRSFKLKAQWLKDNNLGGAVVWPLDMDDFSGSFCHQRHFPL 358 Query: 433 LRAIKYRL 440 +K L Sbjct: 359 TSTLKGDL 366 >5Y2C-A nrPDB Length = 383 Score = 349 bits (896), Expect = 9e-97, Method: Composition-based stats. Identities = 117/422 (27%), Positives = 191/422 (45%), Gaps = 55/422 (13%) Query: 21 ASNLVCYYDSSSYTREGLGKLLNPDLEIALQFCSHLVYGYAGLRGENLQAYSMNENLDIY 80 +VCYY + ++ R GK D+ + C+H++Y +A L E L S + LD+ Sbjct: 2 RFKVVCYYTNWAWYRPDNGKYTPGDINP--ELCTHIIYAFAVLDKEELVIKSHDIWLDVE 59 Query: 81 KHQFSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDLVK 140 + +VT+LK +KVLL +GG D +KY L+ R+ F+ A D ++ Sbjct: 60 NKFYEKVTALKSH--GVKVLLGLGGW---DDSAGDKYSRLVNNVSARR-KFVVHAVDFLE 113 Query: 141 TYGFDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTALVRDV 200 YGFDGLDL + +PK + K+ F LV+++ Sbjct: 114 QYGFDGLDLDWLYPK---------------------CWQVECEKGPDSDKQGFADLVKEL 152 Query: 201 KDSLRADGFLLSLTVLPNVNSTWY-FDIPALNGLVDFVNLATFDFLTPARNPEEADYSAP 259 + + G LLS V + Y +++PAL+ +D+++L T+D+ + ++ + AP Sbjct: 153 RKAFNRRGMLLSAAVSASKRVIDYAYNVPALSMNLDWISLMTYDYHG--QWDKKTGHVAP 210 Query: 260 IYHPDGSKDRLAHLNADFQVEYWLSQGFPSNKINLGVATYGNAWKLTKDSGLEGVPVVPE 319 +Y D D N +F V YW+++G K+ +GV YG ++ + + +G + Sbjct: 211 MYVHDKDTD--NTFNVNFTVNYWINKGADRKKLVVGVPFYGQSFSVVEGAGTG---LGAP 265 Query: 320 TSGPAPEGFQSQKPGLLSYAEICGKLSNPQNQFLKGNESPLRRVSDPTKRFGGIAYRPVD 379 T G +++ G LS+ EIC ++ + DP R G A Sbjct: 266 TYAGGEAGDETRARGFLSFYEICERVKVK----------GWKVHRDPGGRIGPYA----- 310 Query: 380 GQITEGIWVSYDDPDSASNKAAYARVKNLGGVALFDLSYDDFRGQ-CSGDKYPILRAIKY 438 + WVS+DD A +KA Y R LGG + L DDF G+ C K P+L I + Sbjct: 311 --THDDQWVSFDDDFMARHKAEYVRAMELGGSMAWSLDLDDFTGKYCGCGKAPLLTTINH 368 Query: 439 RL 440 L Sbjct: 369 VL 370 >6G9C-A nrPDB Length = 495 Score = 335 bits (859), Expect = 2e-92, Method: Composition-based stats. Identities = 97/430 (22%), Positives = 169/430 (39%), Gaps = 65/430 (15%) Query: 17 STEAASNLVCYYDSSSYTREGLGKLLNPDLEIALQFCSHLVYGYAGLRGE-NLQAYSMNE 75 +++ CY+ + + R G GK + L C ++ Y +A L + + + N+ Sbjct: 28 ASDEKYVRGCYFTNWAQYRPGNGKYNPEHYQANL--CEYIFYAFAKLNDDFTVDQFEWND 85 Query: 76 NLDIYKHQFSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSA 135 +Y V K P LKVLLS+GG + + + FI S Sbjct: 86 IDVLYPG----VMKQKSSQPDLKVLLSLGGW-----NAGTATFKKMAATYSNRAKFISSL 136 Query: 136 YDLVKTYGFDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTA 195 ++ FDG DL +++P++ ++ + L ++ A Sbjct: 137 VSFLQQNKFDGFDLDWEYPESSDKENY------------------------LLLCQEILA 172 Query: 196 LVRDVKDSLRADGFLLSLTVLPNVNSTW-YFDIPALNGLVDFVNLATFDFLTPARNPEEA 254 +V L + V N + +D+PAL ++DFVNL +DF + Sbjct: 173 KFEEVAKCTSTSRLLFTAAVSANPKTVDAGYDVPALAKVLDFVNLMCYDFHGAWE--TQT 230 Query: 255 DYSAPIYHPDGSKDRLAHLNADFQVEYWLSQGFPSNKINLGVATYGNAWKLTKDSGLEGV 314 ++P+Y N + +YW +G P +I +G+ TYG W L+ S + Sbjct: 231 GINSPLYSRKEDSSEFKMWNVEQSSKYWSDKGMPKKQIIIGLPTYGRGWTLSDASKTD-- 288 Query: 315 PVVPETSGPAPEGFQSQKPGLLSYAEICGKLSNPQNQFLKGNESPLRRVSDPTKRFGGIA 374 + G + ++ G++SY E+C KLS S + + + Sbjct: 289 -IGAPAQGSSTATEYLREAGVISYYEVCQKLS-----------------SGAKRVWDDES 330 Query: 375 YRPVDGQITEGIWVSYDDPDSASNKAAYARVKNLGGVALFDLSYDDFRGQCS----GDKY 430 P + W SYDD +S K + + +N GG ++ L YDDF G G KY Sbjct: 331 KTPYL--VQGNQWFSYDDVESMKAKINWIKQENYGGAFVWTLDYDDFLGSFCTEHNGKKY 388 Query: 431 PILRAIKYRL 440 P++ ++ L Sbjct: 389 PLISLMQEIL 398 >6BT9-A nrPDB Length = 672 Score = 293 bits (750), Expect = 1e-79, Method: Composition-based stats. Identities = 97/490 (19%), Positives = 174/490 (35%), Gaps = 117/490 (23%) Query: 17 STEAASNLVCYYDSSSYTREGLGKLLNPDLEIALQFCSHLVYGYAGL-----------RG 65 S + + +V Y+ S G+ +I +HL Y +A + Sbjct: 32 SPKQSQKIVGYFPSWGVY----GRNYQ-VADIDASKLTHLNYAFADICWNGKHGNPSTHP 86 Query: 66 ENLQAYSMN----------------------ENLDIYK------------------HQFS 85 +N + N D+ K F Sbjct: 87 DNPNKQTWNCKESGVPLQNKEVPNGTLVLGEPWADVTKSYPVSGTTWEDCDKYARCGNFG 146 Query: 86 EVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDLVKTYGFD 145 E+ LK KYPHLK ++SVGG N++ D+ EK R++ F S ++ YGFD Sbjct: 147 ELKRLKAKYPHLKTIISVGGWT-----WSNRFSDMAADEKTRKV-FAESTVAFLRAYGFD 200 Query: 146 GLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTALVRDVKDSL- 204 G+DL +++P + + K+ FT L++DV+++L Sbjct: 201 GVDLDWEYPGVET---------------------IPGGSYRPEDKQNFTLLLQDVRNALN 239 Query: 205 -----RADGFLLSLTVLPNVNSTWYFDIPALNGLVDFVNLATFDFLTPARNPEEADYSAP 259 +LL++ + + ++ ++ ++D++N+ T+DF ++++A Sbjct: 240 KAGAEDGKQYLLTIASGASQRYADHTELKKISQILDWINIMTYDFHGGWEA--TSNHNAA 297 Query: 260 IYHPDGSKDRLAHLNADFQVEYWLSQGFPSNKINLGVATYGNAWKLTKDSGLEGVPVVPE 319 +Y + D + + ++G P +K+ LGV YG WK Sbjct: 298 LYKDPNDPAANTNFYVDGAINVYTNEGVPVDKLVLGVPFYGRGWKSCGKENNGQYQPCKP 357 Query: 320 TSGPAPEGFQSQKP------GLLSYAEICGKLSNPQNQFLKGNESPLRRVSDPTKRFGGI 373 S + G+ Y ++ N + + + Sbjct: 358 GSDGKLASKGTWDDYSTGDTGVYDYGDLAANYVNK---------------NGFVRYWNDT 402 Query: 374 AYRPVDGQITEGIWVSYDDPDSASNKAAYARVKNLGGVALFDLSYD---DFRGQCSGDKY 430 A P T G ++SYDD +S K Y + K L G ++LS D + CSG K Sbjct: 403 AKVPYLYNATTGTFISYDDNESMKYKTDYIKTKGLSGAMFWELSGDCRTSPKYSCSGPK- 461 Query: 431 PILRAIKYRL 440 +L + L Sbjct: 462 -LLDTLVKEL 470 >1ITX-A nrPDB Length = 419 Score = 280 bits (717), Expect = 7e-76, Method: Composition-based stats. Identities = 87/455 (19%), Positives = 165/455 (36%), Gaps = 105/455 (23%) Query: 16 ASTEAASNLVCYYDSSSYTREGLGKLLNPDLEIALQFCSHLVYGYAGLRGENL------- 68 A + +V YY S + G+ N +I +H+ Y +A + + Sbjct: 6 AEAADSYKIVGYYPSWAAY----GRNYN-VADIDPTKVTHINYAFADICWNGIHGNPDPS 60 Query: 69 ----------------------------------QAYSMNENLDIYKHQFSEVTSLKRKY 94 + ++ + +++ LK+ Sbjct: 61 GPNPVTWTCQNEKSQTINVPNGTIVLGDPWIDTGKTFAGDTWDQPIAGNINQLNKLKQTN 120 Query: 95 PHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDLVKTYGFDGLDLAYQFP 154 P+LK ++SVGG N++ D+ R++ F SA D ++ Y FDG+DL +++P Sbjct: 121 PNLKTIISVGGWT-----WSNRFSDVAATAATREV-FANSAVDFLRKYNFDGVDLDWEYP 174 Query: 155 KNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTALVRDVKDSLRADG------ 208 +G + K+ +T L+ +++ L A G Sbjct: 175 ---------------------VSGGLDGNSKRPEDKQNYTLLLSKIREKLDAAGAVDGKK 213 Query: 209 FLLSLTVLPNVNSTWYFDIPALNGLVDFVNLATFDFLTPARNPEEADYSAPI-YHPDGSK 267 +LL++ + ++ + +VD++N+ T+DF + + + ++AP+ Y P S Sbjct: 214 YLLTIASGASATYAANTELAKIAAIVDWINIMTYDFNGAWQ--KISAHNAPLNYDPAASA 271 Query: 268 DRL---AHLNADFQVEYWLSQGFPSNKINLGVATYGNAWKLTKDSGLEGVPVVPETSGPA 324 + N + L G P+ K+ LGV YG W +G S Sbjct: 272 AGVPDANTFNVAAGAQGHLDAGVPAAKLVLGVPFYGRGWDGCAQAGNGQYQTCTGGSSVG 331 Query: 325 PEGFQSQKPGLLSYAEICGKLSNPQNQFLKGNESPLRRVSDPTKRFGGIAYRPVDGQITE 384 + + G + ++ N + T+ + A P + Sbjct: 332 -----TWEAGSFDFYDLEANYINK---------------NGYTRYWNDTAKVPYLYNASN 371 Query: 385 GIWVSYDDPDSASNKAAYARVKNLGGVALFDLSYD 419 ++SYDD +S K AY + K LGG ++LS D Sbjct: 372 KRFISYDDAESVGYKTAYIKSKGLGGAMFWELSGD 406 >3CHF-A nrPDB Length = 433 Score = 277 bits (707), Expect = 1e-74, Method: Composition-based stats. Identities = 88/419 (21%), Positives = 154/419 (36%), Gaps = 81/419 (19%) Query: 16 ASTEAASNLVCYYDSSSYTREGLGKLLNPDLEIALQFCSHLVYGYAGLRGENLQAYSMNE 75 A + V Y+ + + G+ NP ++ ++ +H++Y +A +R E + Y + Sbjct: 37 ARASSGYRSVVYFVNWAIY----GRNHNPQ-DLPVERLTHVLYAFANVRPETGEVYMTDS 91 Query: 76 NLDIYKHQ---------------FSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDL 120 DI KH ++ LK++ +LKVLLS+GG Sbjct: 92 WADIEKHYPGDSWSDTGNNVYGCIKQLYLLKKQNRNLKVLLSIGGWTYSPN------FAP 145 Query: 121 LEGEKVRQIGFIRSAYDLVKTYGFDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDF 180 + F ++A L++ GFDGLD+ +++P+N + L Sbjct: 146 AASTDAGRKNFAKTAVKLLQDLGFDGLDIDWEYPENDQQANDFVL--------------- 190 Query: 181 IVDPHAALHKEQFTALVRDVKDSLRADGFLLSLTVLPNVNSTWYFDIPALNGLVDFVNLA 240 L KE TAL + FLL++ + + ++ +DF NL Sbjct: 191 -------LLKEVRTALDSYSAANAGGQHFLLTVASPAGPDKIKVLHLKDMDQQLDFWNLM 243 Query: 241 TFDFLTPARNPEEADYSAPIYHPDGSKDRLAHLNADFQVEYWLSQGFPSNKINLGVATYG 300 +D+ + + + A +Y+ D S N ++ + + G P+NKI LG+ YG Sbjct: 244 AYDYAGSFSS--LSGHQANVYN-DTSNPLSTPFNTQTALDLYRAGGVPANKIVLGMPLYG 300 Query: 301 NAWKLTKDSGLEGVPVVPETSGPAPEGFQSQKPGLLSYAEICGKLSNPQNQFLKGNESPL 360 ++ T G V G S + G+ Y + Sbjct: 301 RSFANTDGPGKPYNGV----------GQGSWENGVWDYKALPQA---------------- 334 Query: 361 RRVSDPTKRFGGIAYRPVDGQITEGIWVSYDDPDSASNKAAYARVKNLGGVALFDLSYD 419 T+ T +SYD+P A+ K+ Y + LGG +D S D Sbjct: 335 ----GATEHVLPDIMASYSYDATNKFLISYDNPQVANLKSGYIKSLGLGGAMWWDSSSD 389 >5GQB-A nrPDB Length = 553 Score = 266 bits (679), Expect = 2e-71, Method: Composition-based stats. Identities = 83/361 (22%), Positives = 146/361 (40%), Gaps = 49/361 (13%) Query: 61 AGLRGENLQAYSMNENLDIYKHQFSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDL 120 A L+ S NE YK F ++ LK+ P LK+L S+GG DP + Sbjct: 226 AALQKPQKGLSSWNE---PYKGNFGQLMMLKQAKPDLKILPSIGGWTLADP-----FFFF 277 Query: 121 LEGEKVRQIGFIRSAYDLVKTYGF-DGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGD 179 ++ ++ F+ S D ++T+ F DG+D+ ++FP K + +LG Sbjct: 278 --TDETKRRRFVASVKDFLQTWKFFDGVDIDWEFPGGK--GANPNLGSPKDG-------- 325 Query: 180 FIVDPHAALHKEQFTALVRDVKDSLRADGFLLSLTVLPNVNSTWYFDIPALNGLVDFVNL 239 + + L KE L ++ + L+ + + D A +D + Sbjct: 326 ---EIYVLLMKELREMLNELSAET--GRKYELTSAISAGWDKIQVVDYSAAQKYMDHIFF 380 Query: 240 ATFDFLTPARNPEEADYSAPIYHPDGSKDRLAHLNADFQVEYWLSQGFPSNKINLGVATY 299 ++DF N + + A +Y PD ++ DF V++ L+QG KI +GVA Y Sbjct: 381 MSYDFKGAWSN-DTLGHQASLYAPDWNEKET--YTTDFGVQFLLAQGVSPKKIVVGVAMY 437 Query: 300 GNAWKLTKDSGLEGVPVVPETSGPAPEGFQSQKPGLLSYAEICGKLSNPQNQFLKGNESP 359 G W + P +GP +Q G++ Y EI +++ + ++ Sbjct: 438 GRGWTGVHG-YKDNNPFTGNATGPVKGTWQ---DGVVDYREIATEIAQGKWEYH------ 487 Query: 360 LRRVSDPTKRFGGIAYRPVDGQITEGIWVSYDDPDSASNKAAYARVKNLGGVALFDLSYD 419 + +A P + G ++YDD S K Y R LGG+ +++ D Sbjct: 488 ----------YDKVAQAPYVFRPATGDLITYDDARSTIEKGKYVRANKLGGLFAWEIDAD 537 Query: 420 D 420 + Sbjct: 538 N 538 >3G6L-A nrPDB Length = 406 Score = 265 bits (676), Expect = 3e-71, Method: Composition-based stats. Identities = 79/421 (18%), Positives = 150/421 (35%), Gaps = 79/421 (18%) Query: 15 AASTEAASNLVCYYDSSSYTREGL-GKLLNPDLEIALQFCSHLVYGYAGLRGENLQAYSM 73 AST+ ++ ++ +T G+ G+ P A + H++Y + LR + YS Sbjct: 9 LASTDLSTRATGSINAVYFTNWGIYGRNFQPADLQASKIL-HVLYSFMNLRVDG-TVYSG 66 Query: 74 NENLDIYKHQ---------------FSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYI 118 + D+ KH ++ LK+ LK++LS+GG + Sbjct: 67 DTYADLEKHYSDDSWNDIGTNAYGCVKQLYKLKKANRSLKIMLSIGGWT-----WSTNFP 121 Query: 119 DLLEGEKVRQIGFIRSAYDLVKTYGFDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTG 178 E R F ++A + +K +GFDG+D+ +++P ++ ++ L + +++ Sbjct: 122 AAASTEATRAT-FAKTAVEFMKDWGFDGIDVDWEYPASETDA--NNMVLLLQRVRQELDS 178 Query: 179 DFIVDPHAALHKEQFTALVRDVKDSLRADGFLLSLTVLPNVNSTWYFDIPALNGLVDFVN 238 F LS+ + + L ++D +N Sbjct: 179 YSATYA--------------------NGYHFQLSIAAPAGPSHYNVLKLAQLGSVLDNIN 218 Query: 239 LATFDFLTPARNPEEADYSAPIYHPDGSKDRLAHLNADFQVEYWLSQGFPSNKINLGVAT 298 L +D+ + + + +Y P S + V+ +++ G P++KI LG+ Sbjct: 219 LMAYDYAGSWDS--VSGHQTNLY-PSTSNPSSTPFSTKAAVDAYIAAGVPASKIILGMPI 275 Query: 299 YGNAWKLTKDSGLEGVPVVPETSGPAPEGFQSQKPGLLSYAEICGKLSNPQNQFLKGNES 358 YG A+ T G + G S + G+ Y + Sbjct: 276 YGRAFVGTDGPGK----------PYSTIGEGSWESGIWDYKVLPKA-------------- 311 Query: 359 PLRRVSDPTKRFGGIAYRPVDGQITEGIWVSYDDPDSASNKAAYARVKNLGGVALFDLSY 418 T A + +SYD PD K +YA+ LGG ++ S Sbjct: 312 ------GATVITDSAAGATYSYDSSSRTMISYDTPDMVRTKVSYAKGLGLGGSMFWEASA 365 Query: 419 D 419 D Sbjct: 366 D 366 >5ZL9-A nrPDB Length = 618 Score = 260 bits (665), Expect = 6e-70, Method: Composition-based stats. Identities = 79/365 (21%), Positives = 149/365 (40%), Gaps = 53/365 (14%) Query: 60 YAGLRGENLQAYSMNENLDIYKHQFSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYID 119 +A L+ + + D YK F ++ +LK+ +P LK+L S+GG DP Sbjct: 209 FAALQKAQKGVTAWD---DPYKGNFGQLMALKQAHPDLKILPSIGGWTLSDP-------F 258 Query: 120 LLEGEKVRQIGFIRSAYDLVKTYGF-DGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTG 178 G+KV++ F+ S + ++T+ F DG+D+ ++FP K + +LG Sbjct: 259 FFMGDKVKRDRFVGSVKEFLQTWKFFDGVDIDWEFPGGK--GANPNLGSPQDG------- 309 Query: 179 DFIVDPHAALHKEQFTALVRDVKDSLRADGFLLSLTVLPNVNSTWYFDIPALNGLVDFVN 238 + + L KE L + ++ R +++ + +Y + +D + Sbjct: 310 ----ETYVLLMKELRAMLDQLSVETGRKYELTSAISAGKDKIDKFYSFVNVAQNSMDHIF 365 Query: 239 LATFDFLTP---ARNPEEADYSAPIYHPDGSKDRLAHLNADFQVEYWLSQGFPSNKINLG 295 L ++DF + +AP + PD + + +NA L+QG KI +G Sbjct: 366 LMSYDFYGAFDLKNLGHQTALNAPAWKPDTAYTTVNGVNA------LLAQGVKPGKIVVG 419 Query: 296 VATYGNAWKLTKDSGLEGVPVVPETSGPAPEGFQSQKPGLLSYAEICGKLSNPQNQFLKG 355 A YG W +P +GP + + G++ Y +I G+ + + Q+ Sbjct: 420 TAMYGRGWTGVNGYQNN-IPFTGTATGPVKGTW---ENGIVDYRQIAGQFMSGEWQY--- 472 Query: 356 NESPLRRVSDPTKRFGGIAYRPVDGQITEGIWVSYDDPDSASNKAAYARVKNLGGVALFD 415 + A P + + G +++DD S K Y K LGG+ ++ Sbjct: 473 -------------TYDATAEAPYVFKPSTGDLITFDDARSVQAKGKYVLDKQLGGLFSWE 519 Query: 416 LSYDD 420 + D+ Sbjct: 520 IDADN 524 >5GZU-A nrPDB Length = 885 Score = 258 bits (658), Expect = 4e-69, Method: Composition-based stats. Identities = 87/443 (19%), Positives = 158/443 (35%), Gaps = 90/443 (20%) Query: 15 AASTEAASNLVCYYDSSSYTREGLGKLLNPDLEIALQFCSHLVYGYAGLRGENLQAYSMN 74 + E +V Y + + + +HL Y + + + + Sbjct: 19 LGTLEVQGKIVSYIPAWVDW-------AKDERGVDATKFTHLYYAFGRINNGKVVTIKED 71 Query: 75 ENLD----------------IYKHQFSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYI 118 + + +T LK K P+LKVL+S+GG + Sbjct: 72 AKWTEDPTITEADRIKRRNNPDESNLAYLTGLKAKNPNLKVLVSIGGWE------AEGFS 125 Query: 119 DLLEGEKVRQIGFIRSAYDLVKTYGFDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTG 178 D + R++ F SA D + Y DG+DL +++P V+G G+ Sbjct: 126 DAALTPESREV-FANSALDFMNKYNLDGIDLDWEYP------VYGAWGVI---------- 168 Query: 179 DFIVDPHAALHKEQFTALVRDVKDSLRADG------FLLSLTVLPNVNSTWYFDIPALNG 232 K FTAL++ +++ L A + L++ + T ++ + Sbjct: 169 -----KSRPEDKANFTALLKLLREKLDAQSTTTNKYYELAIAAGASKTYTDSVELTKITP 223 Query: 233 LVDFVNLATFDFLTPARNPEEADYSAPIYHPDGSKDRLAHLNADFQVEYWLSQGFPSNKI 292 +D++NL T+D + +Y L+ D V+ +L+ G P+ K+ Sbjct: 224 YLDYINLMTYDLHGGWD--PATSHHTAVY-----SATNNQLSVDSTVKLYLNNGVPAEKL 276 Query: 293 NLGVATYGNAWKLTKDSGLEGVPVVPETSGPAPEGFQSQKPGLLSYAEICGKLSNPQNQF 352 +G A Y W+ ++ G T G Q+ PG + Y+E+ N Sbjct: 277 MVGGAFYSRVWQNVENKG---------TGLSEKAGSQAGSPGTIVYSELVNNYINK---- 323 Query: 353 LKGNESPLRRVSDPTKRFGGIAYRPVDGQITEGIWVSYDDPDSASNKAAYARVKNLGGVA 412 + T+ + A P ++SY+D SA+ KA Y + NL G Sbjct: 324 -----------NGYTRYWDDTAKAPYLFN--GSTFISYEDTASAAYKAEYIKQNNLAGFM 370 Query: 413 LFDLSYDDFRGQCSGDKYPILRA 435 ++ S D + + Y L A Sbjct: 371 YWEYSQDSDSHELANTIYSRLYA 393 Score = 248 bits (632), Expect = 5e-66, Method: Composition-based stats. Identities = 85/427 (19%), Positives = 160/427 (37%), Gaps = 82/427 (19%) Query: 34 TREGLGKLLNPDLEIALQFCSHLVYGYAGLRGENLQAYSMNENL---------------D 78 G N ++ +H+ Y +A ++ + S + N + Sbjct: 518 YVPGWVDWTNSAYKVDATKLTHINYAFARIKDNKVVKISEDINWVNEFPSEEIREQRRNN 577 Query: 79 IYKHQFSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDL 138 F+ + +LK++ P LKVL+S+GG + D + R+ SA Sbjct: 578 PDDANFAYLKTLKQQNPSLKVLVSIGGW------AAEGFSDAALTPETRE-ELANSAIAF 630 Query: 139 VKTYGFDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTALVR 198 + YGFDG+DL +++P G F V K+ FTAL++ Sbjct: 631 MHQYGFDGIDLDWEYP---------------------VYGAFGVIKSRPEDKQNFTALLK 669 Query: 199 DVKDSLRADG------FLLSLTVLPNVNSTWYFDIPALNGLVDFVNLATFDFLTPARNPE 252 ++ L +G + L++ ++ ++ +D++++ T+D+ + Sbjct: 670 LFREKLDVEGALHGKYYELAIASAAAPIYINSVELDKIHQYLDYMSVMTYDYHGSWES-- 727 Query: 253 EADYSAPIYHPDGSKDRLAHLNADFQVEYWLSQGFPSNKINLGVATYGNAWKLTKDSGLE 312 + + A +Y S +AD + + QG P++K+ +G A Y W + Sbjct: 728 KTAHQASVYTSALSPG---DFSADSVLTAYRKQGVPASKLVIGGAFYARGWVNVPNIN-- 782 Query: 313 GVPVVPETSGPAPEGFQSQKPGLLSYAEICGKLSNPQNQFLKGNESPLRRVSDPTKRFGG 372 G Q++ PG +Y ++ + T+ + Sbjct: 783 -------HGLFQQAGDQAKNPGTPTYNDLVKDYFDKGY----------------TRYWDN 819 Query: 373 IAYRPVDGQ--ITEGIWVSYDDPDSASNKAAYARVKNLGGVALFDLSYDDFRGQCSGDKY 430 A P G +++YDD +S KA YA+ + L GV +D S D G+ G + Sbjct: 820 SAKAPYLYNPDANGGTFITYDDEESLKYKAEYAKNQGLRGVMFWDYSQD-ISGKLLGAIF 878 Query: 431 PILRAIK 437 L+A K Sbjct: 879 NELKAPK 885 >3ALF-A nrPDB Length = 353 Score = 256 bits (654), Expect = 1e-68, Method: Composition-based stats. Identities = 81/377 (21%), Positives = 148/377 (39%), Gaps = 59/377 (15%) Query: 47 EIALQFCSHLVYGYAGLRGENLQAYSMNENLDIYKHQFSEVTSLKRKYPHLKVLLSVGGD 106 I +HL +A L + Q EN D ++ ++++RK P +K LS+ G Sbjct: 19 NIDSTLFTHLFCAFADLNPQLNQLIISPENQDSFR---QFTSTVQRKNPSVKTFLSIAGG 75 Query: 107 HDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDLVKTYGFDGLDLAYQFPKNKPRKVHGDLG 166 + ++ + + FI S+ L + GF GLDL +++P + + Sbjct: 76 RANSTAYG-----IMARQPNSRKSFIDSSIRLARQLGFHGLDLDWEYPLSAADMTN---- 126 Query: 167 LAWKSIKKLFTGDFIVDPHAALHKEQFTALVRDVKDSLRADGFLLSLTVLPNVNSTWYFD 226 L E TA+ + ++S RA L + + + Sbjct: 127 ------------------LGTLLNEWRTAINTEARNSGRAALLLTAAVSNSPRVNGLNYP 168 Query: 227 IPALNGLVDFVNLATFDFLTPARNPEEADYSAPIYHPDGSKDRLAHLNADFQVEYWLSQG 286 + +L +D++NL +DF P +P + + A ++ P + H++ + W+ G Sbjct: 169 VESLARNLDWINLMAYDFYGPNWSPSQTNSHAQLFDP------VNHVSGSDGINAWIQAG 222 Query: 287 FPSNKINLGVATYGNAWKLTKDSGLEGVPVVPETSGPAPEGFQSQKPGLLSYAEICGKLS 346 P+ K+ LG+ YG AW+L + G+ +G + G + G ++Y I + Sbjct: 223 VPTKKLVLGIPFYGYAWRLVNA-NIHGLRA--PAAGKSNVG--AVDDGSMTYNRIRDYIV 277 Query: 347 NPQNQFLKGNESPLRRVSDPTKRFGGIAYRPVDGQITEGIWVSYDDPDSASNKAAYARVK 406 ES V + T G Y + W+SYDD + NK Y + + Sbjct: 278 ----------ESRATTVYNATI-VGDYCY-------SGSNWISYDDTQTVRNKVNYVKGR 319 Query: 407 NLGGVALFDLSYDDFRG 423 L G + ++ D G Sbjct: 320 GLLGYFAWHVAGDQNWG 336 >6EPB-A nrPDB Length = 423 Score = 256 bits (654), Expect = 1e-68, Method: Composition-based stats. Identities = 77/408 (18%), Positives = 145/408 (35%), Gaps = 82/408 (20%) Query: 27 YYDSSSYTREGLGKLLNPDLEIALQFCSHLVYGYAGLRGENLQAYSMNENLDIYKHQ--- 83 Y+ + + P +A +H++Y + L+ + S + D KH Sbjct: 43 YFTNWGIYD----RNFQPADLVASDV-THVIYSFMNLQADG-TVISGDTYADYEKHYADD 96 Query: 84 ------------FSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGF 131 ++ +K+ LKVLLS+GG + + R+ F Sbjct: 97 SWNDVGTNAYGCVKQLFKVKKANRGLKVLLSIGGWT-----WSTNFPSAASTDANRK-NF 150 Query: 132 IRSAYDLVKTYGFDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKE 191 ++A +K +GFDG+D+ +++P + + + L L KE Sbjct: 151 AKTAITFMKDWGFDGIDIDWEYPADATQASNMIL----------------------LLKE 188 Query: 192 QFTALVRDVKDSLRADGFLLSLTVLPNVNSTWYFDIPALNGLVDFVNLATFDFLTPARNP 251 + L FLL++ ++ + L ++D++NL +D+ Sbjct: 189 VRSQLDAYAAQYAPGYHFLLTIAAPAGKDNYSKLRLADLGQVLDYINLMAYDY--AGSFS 246 Query: 252 EEADYSAPIYHPDGSKDRLAHLNADFQVEYWLSQGFPSNKINLGVATYGNAWKLTKDSGL 311 + A +++ S N D V+ +++ G P+NKI LG+ YG +++ T G Sbjct: 247 PLTGHDANLFNNP-SNPNATPFNTDSAVKDYINGGVPANKIVLGMPIYGRSFQNTAGIGQ 305 Query: 312 EGVPVVPETSGPAPEGFQSQKPGLLSYAEICGKLSNPQNQFLKGNESPLRRVSDPTKRFG 371 V G S + G+ Y + T ++ Sbjct: 306 TYNGV----------GSGSWEAGIWDYKALPKA--------------------GATVQYD 335 Query: 372 GIAYRPVDGQITEGIWVSYDDPDSASNKAAYARVKNLGGVALFDLSYD 419 +A +S+D PD + K AY + LGG ++ S D Sbjct: 336 SVAKGYYSYNSATKELISFDTPDMINTKVAYLKSLGLGGSMFWEASAD 383 >5Z7M-A nrPDB Length = 546 Score = 256 bits (653), Expect = 1e-68, Method: Composition-based stats. Identities = 80/365 (21%), Positives = 146/365 (40%), Gaps = 55/365 (15%) Query: 60 YAGLRGENLQAYSMNENLDIYKHQFSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYID 119 +A L+ + + D YK F ++ +LK+ +P LK+L S+GG DP Sbjct: 209 FAALQKAQKGVTAWD---DPYKGNFGQLMALKQAHPDLKILPSIGGWTLSDP-------F 258 Query: 120 LLEGEKVRQIGFIRSAYDLVKTYG-FDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTG 178 G+KV++ F+ S + ++T+ FDG+D+A++FP K + +LG Sbjct: 259 FFMGDKVKRDRFVGSVKEFLQTWKFFDGVDIAWEFPGGK--GANPNLGSPQDG------- 309 Query: 179 DFIVDPHAALHKEQFTALVRDVKDSLRADGFLLSLTVLPNVNSTWYFDIPALNGLVDFVN 238 + + L KE L + ++ + L+ + + +D + Sbjct: 310 ----ETYVLLMKELRAMLDQLSVET--GRKYELTSAISAGKDMIDKVAYNVAQNSMDHIF 363 Query: 239 LATFDFLTPAR---NPEEADYSAPIYHPDGSKDRLAHLNADFQVEYWLSQGFPSNKINLG 295 L ++DF A + +AP + PD + + +NA L+QG KI +G Sbjct: 364 LMSYDFYGAADLKNLGHQTALNAPAWKPDTAYTTVNGVNA------LLAQGVKPGKIVVG 417 Query: 296 VATYGNAWKLTKDSGLEGVPVVPETSGPAPEGFQSQKPGLLSYAEICGKLSNPQNQFLKG 355 A YG W +P +GP + + G++ Y +I G+ + + Q+ Sbjct: 418 TAMYGRGWTGVNGYQNN-IPFTGTATGPVKGTW---ENGIVDYRQIAGQFMSGEWQY--- 470 Query: 356 NESPLRRVSDPTKRFGGIAYRPVDGQITEGIWVSYDDPDSASNKAAYARVKNLGGVALFD 415 + A P + + G +++DD S K Y K LGG+ Sbjct: 471 -------------TYDATAEAPYVFKPSTGDLITFDDARSVQAKGKYVLDKQLGGLFSAM 517 Query: 416 LSYDD 420 + D+ Sbjct: 518 IDADN 522 >5DF0-A nrPDB Length = 545 Score = 253 bits (647), Expect = 7e-68, Method: Composition-based stats. Identities = 83/439 (18%), Positives = 152/439 (34%), Gaps = 96/439 (21%) Query: 24 LVCYYDSSSYTREGLGKLLNPDLEIALQFCSHLVYGY----------------------- 60 + Y+ G+ D SHL+YG+ Sbjct: 150 VAAYFVEWGVY----GRNFPVDKVPLPNL-SHLLYGFIPICGGDGINDALKTISGSFESL 204 Query: 61 ------------------AGLRGENLQAYSMNENLDIYKHQFSEVTSLKRKYPHLKVLLS 102 A ++ + NE YK F ++ + K PHLK+L S Sbjct: 205 QRSCKGREDFKVAIHDPWAAVQKPQKSVSAWNE---PYKGNFGQLMAAKLANPHLKILPS 261 Query: 103 VGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDLVKTYG-FDGLDLAYQFPKNKPRKV 161 +GG DP + + ++ F+ S + ++ + FDG+D+ ++FP K Sbjct: 262 IGGWTLSDPFY-------FMHDVEKRNVFVDSVKEFLQVWKFFDGVDVDWEFPGGK--GA 312 Query: 162 HGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTALVRDVKDSLRADGFLLSLTVLPNVNS 221 + LG A + K L E+ A++ D+ ++ + L+ + + Sbjct: 313 NPSLGDAERDAKTYI-----------LLLEELRAMLDDL-EAQTGRVYELTSAISAGYDK 360 Query: 222 TWYFDIPALNGLVDFVNLATFDFLTPARNPEEADYSAPIYHPDGSKDRLAHLNADFQVEY 281 + + + L ++DF N + Y +Y P + + L + V+ Sbjct: 361 IAVVNYAEAQKSLGKIFLMSYDFKGAWSNTDL-GYQTTVYAPSWNSEEL--YTTHYAVDA 417 Query: 282 WLSQGFPSNKINLGVATYGNAWKLTKDSGLEGVPVVPETSGPAPEGFQSQKPGLLSYAEI 341 L QG NKI +GVA YG W + + +GP + + G++ Y +I Sbjct: 418 LLKQGVDPNKIIVGVAMYGRGWTGVTNYTND-NYFSGTGNGPVSGTW---EDGVVDYRQI 473 Query: 342 CGKLSNPQNQFLKGNESPLRRVSDPTKRFGGIAYRPVDGQITEGIWVSYDDPDSASNKAA 401 L+N F + ++G +S+D DS K Sbjct: 474 QKDLNNYVYTFDSAAQ------------------ASYVFDKSKGDLISFDSVDSVLGKVK 515 Query: 402 YARVKNLGGVALFDLSYDD 420 Y LGG+ +++ D+ Sbjct: 516 YVDRNKLGGLFAWEIDADN 534 >3ARQ-A nrPDB Length = 584 Score = 250 bits (639), Expect = 6e-67, Method: Composition-based stats. Identities = 85/459 (18%), Positives = 157/459 (34%), Gaps = 91/459 (19%) Query: 17 STEAASNLVCYYDSSSYTREGLGKLLNPDLEIALQFCSHLVYGYAGLRGENLQAYS---- 72 +T+ + + Y+ G+ D +H++YG+ + G N S Sbjct: 133 NTDPSIVMGTYFVEWGIY----GRDYTVDNMPVDNL-THILYGFIPICGPNESVKSVGGN 187 Query: 73 ---------------------------------MNENLDIYKHQFSEVTSLKRKYPHLKV 99 +E K ++ + +LK++ P LK+ Sbjct: 188 SFNALQTACRGVNDYEVVIHDPWAAYQKSFPQAGHEYSTPIKGNYAMLMALKQRNPDLKI 247 Query: 100 LLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDLVKTYGF-DGLDLAYQFPKNKP 158 + S+GG DP + D + +K + F+ S +KT+ F DG+D+ ++FP Sbjct: 248 IPSIGGWTLSDP-----FYDFV--DKKNRDTFVASVKKFLKTWKFYDGVDIDWEFPGGGG 300 Query: 159 RKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTALVRDVKDSLRADGFLLSLTVLPN 218 + + AL +E L D ++ + L+ + Sbjct: 301 AAADKGDPVN------------DGPAYIALMRELRVML--DELEAETGRTYELTSAIGVG 346 Query: 219 VNSTWYFDIPALNGLVDFVNLATFDFLTPARN---PEEADYSAPIYHP----------DG 265 + D +D++ T+DF N + A Y P +G Sbjct: 347 YDKIEDVDYADAVQYMDYIFAMTYDFYGGWNNVPGHQTALYCGSFMRPGQCDGGGVDENG 406 Query: 266 SKDRLAHLNADFQVEYWLSQGFPSNKINLGVATYGNAWKLTKDSGLE--GVPVVPETSGP 323 + AD ++ L+QG P+NK+ LG A YG W+ L P+ +G Sbjct: 407 EPYKGPAYTADNGIQLLLAQGVPANKLVLGTAMYGRGWEGVTPDTLTDPNDPMTGTATGK 466 Query: 324 --APEGFQSQKPGLLSYAEICGKLSNPQNQFLKGNESPLRRVSDPTKRFGGIAYRPVDGQ 381 + G++ Y I + N + G E + A P Sbjct: 467 LKGSTAQGVWEDGVIDYKGIKSFMLGANNTGINGFE----------YGYDAQAEAPWVWN 516 Query: 382 ITEGIWVSYDDPDSASNKAAYARVKNLGGVALFDLSYDD 420 + G +++DD S K YA+ L G+ +++ D+ Sbjct: 517 RSTGELITFDDHRSVLAKGNYAKSLGLAGLFSWEIDADN 555 >3QOK-A nrPDB Length = 420 Score = 248 bits (634), Expect = 2e-66, Method: Composition-based stats. Identities = 94/421 (22%), Positives = 176/421 (41%), Gaps = 70/421 (16%) Query: 25 VCYYDSSSYTREGLGKLLNPDLE-IALQFCSHLVYGYAGLRGENLQAY---------SMN 74 V Y++ G G D++ + ++ +HL Y + + + Sbjct: 29 VGYFNGGGDVTAGPG----GDIDKLDVRQITHLNYSFGLIYNDEKDETNAALKDPAHLHE 84 Query: 75 ENLDIY-KHQFSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIR 133 L + ++ +L+++ P LKVLLSVGG + + R + FIR Sbjct: 85 IWLSPKVQADLQKLPALRKQNPDLKVLLSVGGW------GARGFSGAAATAESRAV-FIR 137 Query: 134 SAYDLVKTYGFDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQF 193 SA +++ YG DG+DL ++FP V+G GL ++ F Sbjct: 138 SAQKIIQQYGLDGIDLDWEFP------VNGAWGLV---------------ASQPADRDNF 176 Query: 194 TALVRDVKDSLRADGFLLSLTVLPNVNS-TWYFDIPALNGLVDFVNLATFDFLTPARNPE 252 TAL++ +++++ + L+++ V N S + D+ A+ +++++NL T+D + Sbjct: 177 TALLKSLREAV-GEQKLVTIAVGANAESPKSWVDVKAVAPVLNYINLMTYDMAYGTQYFN 235 Query: 253 EADYSAPIYHPDGSKDRLAHLNADFQVEYWLSQGFPSNKINLGVATYGNAWKLTKDSGLE 312 Y + + + D+ +ADF V +L+ G +++NLG+ YG K + G++ Sbjct: 236 SNLYDSSHWPTVAAADK---YSADFVVNNYLAAGLKPSQMNLGIGFYGRVPKRAVEPGID 292 Query: 313 GV-------PVVPETSGP------APEGFQSQKPGLLSYAEICGKLSNPQNQFLKGNESP 359 PV GP A G+ K + Y +I GKL N + Sbjct: 293 WTKADAQNNPVTQPYFGPQQIALFASLGYDLSKDTYVKYNDIVGKLLN-------DPQKR 345 Query: 360 LRRVSDPTKRFGGIAYRPVDGQITEGIWVSYDDPDSASNKAAYARVKNLGGVALFDLSYD 419 D + ++ + +G+ +SY++P S + KA Y + K L G ++ D Sbjct: 346 FTEHWDDEAKVPWLSVQSAEGKPLFA--LSYENPRSVAIKADYIKAKGLAGAMFWEYGAD 403 Query: 420 D 420 D Sbjct: 404 D 404 >1LL6-A nrPDB Length = 392 Score = 248 bits (633), Expect = 3e-66, Method: Composition-based stats. Identities = 84/412 (20%), Positives = 148/412 (35%), Gaps = 82/412 (19%) Query: 23 NLVCYYDSSSYTREGLGKLLNPDLEIALQFCSHLVYGYAGLRGENLQAYSMNENLDIYKH 82 V Y+ + + G+ NP A QF +H++Y +A +R + Y + D KH Sbjct: 4 RSVVYFVNWAIY----GRGHNPQDLKADQF-THILYAFANIRPSG-EVYLSDTWADTDKH 57 Query: 83 Q---------------FSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVR 127 ++ LK+ +LK LLS+GG + Sbjct: 58 YPGDKWDEPGNNVYGCIKQMYLLKKNNRNLKTLLSIGGWTYSPN------FKTPASTEEG 111 Query: 128 QIGFIRSAYDLVKTYGFDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAA 187 + F ++ L+K GFDG+D+ +++P+++ + L Sbjct: 112 RKKFADTSLKLMKDLGFDGIDINWEYPEDEKQANDFVL---------------------- 149 Query: 188 LHKEQFTALVRDVKDSLRADGFLLSLTVLPNVNSTWYFDIPALNGLVDFVNLATFDFLTP 247 L K AL FLL++ + + ++ +DF NL +DF Sbjct: 150 LLKACREALDAYSAKHPNGKKFLLTIASPAGPQNYNKLKLAEMDKYLDFWNLMAYDFSGS 209 Query: 248 ARNPEEADYSAPIYHPDGSKDRLAHLNADFQVEYWLSQGFPSNKINLGVATYGNAWKLTK 307 + + + + ++ P +K ++D V+ ++ G P+NKI LG+ YG A+ T Sbjct: 210 WD--KVSGHMSNVF-PSTTKPESTPFSSDKAVKDYIKAGVPANKIVLGMPLYGRAFASTD 266 Query: 308 DSGLEGVPVVPETSGPAPEGFQSQKPGLLSYAEICGKLSNPQNQFLKGNESPLRRVSDPT 367 G V G S + G+ Y + + Q + + D Sbjct: 267 GIGTSFNGV----------GGGSWENGVWDYKD----MPQQGAQVTELEDIAASYSYDKN 312 Query: 368 KRFGGIAYRPVDGQITEGIWVSYDDPDSASNKAAYARVKNLGGVALFDLSYD 419 KR+ +SYD A KA Y +GG ++ S D Sbjct: 313 KRY----------------LISYDTVKIAGKKAEYITKNGMGGGMWWESSSD 348 >6F8N-A nrPDB Length = 414 Score = 247 bits (630), Expect = 7e-66, Method: Composition-based stats. Identities = 93/423 (21%), Positives = 170/423 (40%), Gaps = 60/423 (14%) Query: 20 AASNLVCYYDSSSYTREGLGKLLNPDLEIALQFCSHLVYGYAGLRGENLQAYSMNENLDI 79 A+ V Y++ G G +N ++ + +HL Y + + + Q + D Sbjct: 9 ASYLSVGYFNGGGDVTAGPGGDIN---KLDVTQITHLNYSFGLIYNDEKQE-TNPALKDP 64 Query: 80 YKHQ-----------FSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQ 128 + + L+++ P LKVLLSVGG + + R Sbjct: 65 SRLHQIYLSPKVMADLQLLPVLRKQNPELKVLLSVGGW------GARGFSGAAATAESRA 118 Query: 129 IGFIRSAYDLVKTYGFDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAAL 188 + FIRS ++K Y DG+DL +Q+P V+G GL Sbjct: 119 V-FIRSVQQVIKQYHLDGIDLDWQYP------VNGAWGLVE---------------SQPA 156 Query: 189 HKEQFTALVRDVKDSLRADGFLLSLTVLPNVNS-TWYFDIPALNGLVDFVNLATFDFLTP 247 + FT L+ ++ +L G LL++ V NV S + D+ + +D++NL T+D Sbjct: 157 DRANFTLLLAELHKALD-KGKLLTIAVGANVKSPQEWVDVKGIAPYLDYINLMTYDMAYG 215 Query: 248 ARNPEEADYSAPIYHPDGSKDRLAHLNADFQVEYWLSQGFPSNKINLGVATYGNAWKLTK 307 + Y + + + DR +A+F V+ +L+ G ++NLG+ YG K Sbjct: 216 TQYFNSNLYDSKQWPTVAAADR---YSANFVVDNYLAAGLKPAQLNLGIGFYGRVPKRAT 272 Query: 308 DSGLEGVPVVPETSGPAPEGFQSQKPGLLSYAEICGKLSNPQNQFLKGNESPLRRVSDPT 367 + G++ + F +++ + L ++ + K N+ + ++DP Sbjct: 273 EPGIDWDKADAAKNPVTQPYFTARETAVFK----AMGLDLTKDSYFKYNDIVSKLLNDPQ 328 Query: 368 KR----FGGIAYRPV----DGQITEGIWVSYDDPDSASNKAAYARVKNLGGVALFDLSYD 419 +R + A P + +SY++P S + KA Y + K LGG ++ D Sbjct: 329 RRFTAHWDSDAQVPYLTMKSAEGKPLFAISYENPRSVALKADYIKSKGLGGAMFWEYGAD 388 Query: 420 DFR 422 D Sbjct: 389 DNN 391 >3AQU-A nrPDB Length = 356 Score = 246 bits (628), Expect = 1e-65, Method: Composition-based stats. Identities = 81/381 (21%), Positives = 138/381 (36%), Gaps = 64/381 (16%) Query: 44 PDLEIALQFCSHLVYGYAGLRGENLQAYSMNENLDIYKHQFSEVT-SLKRKYPHLKVLLS 102 P +I +HL +A L + Q + N + +FS T +++R+ P +K LLS Sbjct: 17 PVTDIDSSLFTHLFCAFADLNSQTNQVTVSSAN----QPKFSTFTQTVQRRNPSVKTLLS 72 Query: 103 VGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDLVKTYGFDGLDLAYQFPKNKPRKVH 162 +GG Y + R+ FI S+ + ++YGF GLDL +++P + + Sbjct: 73 IGGGIAD----KTAYASMASNPTSRK-SFIDSSIRVARSYGFHGLDLDWEYPSSATEMTN 127 Query: 163 GDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTALVRDVKDSLRADGFLLSLTVLPNVNST 222 L +E +A+V + S + L + N + Sbjct: 128 ----------------------FGTLLREWRSAVVAEASSSGKPRLLLAAAVFYSNNYYS 165 Query: 223 WYFDIPALNGLVDFVNLATFDFLTPARNPEEADYSAPIYHPDGSKDRLAHLNADFQVEYW 282 + + A+ +D+VNL +DF P + A ++ P A + D W Sbjct: 166 VLYPVSAVASSLDWVNLMAYDFYGPGWS-RVTGPPAALFDPS-----NAGPSGDAGTRSW 219 Query: 283 LSQGFPSNKINLGVATYGNAWKLTKDSGLEGVPVVPETSGPAPEGFQSQKPGLLSYAEIC 342 + G P+ K LG YG AW+LT + + G + Y +I Sbjct: 220 IQAGLPAKKAVLGFPYYGYAWRLTNANSHSYYAPTTGAAISP--------DGSIGYGQIR 271 Query: 343 GKLSNPQNQFLKGNESPLRRVSDPTKRFGGIAYRPVDGQITEGIWVSYDDPDSASNKAAY 402 + + + T + T W+ YDD S K Y Sbjct: 272 KFIVD----------------NGATTVYNSTVVGDYCYAGTN--WIGYDDNQSIVTKVRY 313 Query: 403 ARVKNLGGVALFDLSYDDFRG 423 A+ + L G + + DD G Sbjct: 314 AKQRGLLGYFSWHVGADDNSG 334 >4MNK-A nrPDB Length = 348 Score = 245 bits (625), Expect = 3e-65, Method: Composition-based stats. Identities = 83/381 (21%), Positives = 144/381 (37%), Gaps = 71/381 (18%) Query: 44 PDLEIALQFCSHLVYGYAGLRGENLQAYSMNENLDIYKHQFSEVTSLKRKYPHLKVLLSV 103 P +I + +HL Y +A L N + + K +++R P +K L+S+ Sbjct: 19 PPSKINSRLFTHLYYAFAEL---NAPTFEVRVPPGSEKTAEDFTPTVRRLNPSVKTLISI 75 Query: 104 GGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDLVKTYGFDGLDLAYQFPKNKPRKVHG 163 GG D + L RQ F++S+ L + YGF GLDL Y++P+ + + Sbjct: 76 GGGGSEVRD---NFAKLNSDASARQ-RFVKSSIALARRYGFHGLDLDYEYPEPQLEMENF 131 Query: 164 DLGLAWKSIKKLFTGDFIVDPHAALHKEQFTALVRDVKDSLRADGFLLSLTVL-----PN 218 ++ + TA +R+ + LL+ V Sbjct: 132 VKLVS-----------------------ELTAAIREEARTSGKPRLLLTEAVYFHQKLFP 168 Query: 219 VNSTWYFDIPALNGLVDFVNLATFDFLTPARNPEEADYSAPIYHPDGSKDRLAHLNADFQ 278 + + + +D+VN+ +DF N A P +D + A Sbjct: 169 WEVVTEYPVQFIAAGLDWVNVMAYDFHGSWENFTGA--------PAALRDPNSKFTASVG 220 Query: 279 VEYWLSQGFPSNKINLGVATYGNAWKLTKDSGLEGVPVVPETSGPAPEGFQSQKPGLLSY 338 +E +L+ G P K+ LG+ +G +W L K++ G+ +GP G LS+ Sbjct: 221 IESFLAAGMPPEKLVLGIPLFGRSW-LLKNNNEVGIGAPAVGAGPV--------DGALSF 271 Query: 339 AEICGKLSNPQNQFLKGNESPLRRVSDPTKRFGGIAYRPVDGQITEGIWVSYDDPDSASN 398 +EI + + T AY+ +WV YD+ S + Sbjct: 272 SEIQNFIRGGAREVF------------DTTTVSAYAYKD-------NVWVGYDNQQSVAL 312 Query: 399 KAAYARVKNLGGVALFDLSYD 419 K YA+ K LGG + ++ D Sbjct: 313 KVQYAKEKRLGGYFFWSVNQD 333 >3WD0-A nrPDB Length = 503 Score = 242 bits (616), Expect = 3e-64, Method: Composition-based stats. Identities = 93/453 (20%), Positives = 169/453 (37%), Gaps = 84/453 (18%) Query: 16 ASTEAASNLVCYY-------DSSSYTREGLGKLLNPDLEIAL-QFCSHLVYGYAGLRGEN 67 +S ++ YY ++ + T + ++ A + +H+ + + + Sbjct: 3 SSRSTRKAVIGYYFIPTNQINNYTETDTSVVPFPVSNITPAKAKQLTHINFSFLDINSNL 62 Query: 68 LQAYSMNENLDIYKHQFSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPN--KYIDLLEGEK 125 A+ N + + +T+LK P L+++ S+GG + + + Y++ ++ Sbjct: 63 ECAWDPATNDAKARDVVNRLTALKAHNPSLRIMFSIGGWYYSNDLGVSHANYVNAVKTPA 122 Query: 126 VRQIGFIRSAYDLVKTYGFDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPH 185 R F +S ++K YGFDG+D+ +++P+ A + I+ L I D Sbjct: 123 AR-TKFAQSCVRIMKDYGFDGVDIDWEYPQAAEVDG---FIAALQEIRTLLNQQTIADGR 178 Query: 186 AALHKEQFTALVRDVKDSLRADGFLLSLTVLPNVNSTWYFDIPALNGLVDFVNLATFDFL 245 AL + A S +Y + + +D++NL T+D Sbjct: 179 QALPYQLTIA-----------------GAGGAFFLSRYYSKLAQIVAPLDYINLMTYDLA 221 Query: 246 TPARNPEEADYSAPIYHPDGSKDRLA----------------------HLNADFQVE-YW 282 P + ++ A ++ L D V+ + Sbjct: 222 GPWE--KITNHQAALFGDAAGPTFYNALREANLGWSWEELTRAFPSPFSLTVDAAVQQHL 279 Query: 283 LSQGFPSNKINLGVATYGNAWKLTKDSGLEGVPVVPETSGPAP------------EGFQS 330 + +G PS KI +GV YG A+K G G T G P E + Sbjct: 280 MMEGVPSAKIVMGVPFYGRAFKGVSG-GNGGQYSSHSTPGEDPYPNADYWLVGCDECVRD 338 Query: 331 QKPGLLSYAEICGKLSNPQNQFLKGNESPLRRVSDPTKRFGGIAYRPVDGQITEGIWVSY 390 + P + SY ++ Q L+GN R +D TK P G++V+Y Sbjct: 339 KDPRIASYRQL--------EQMLQGNYGYQRLWNDKTKT-------PYLYHAQNGLFVTY 383 Query: 391 DDPDSASNKAAYARVKNLGGVALFDLSYDDFRG 423 DD +S KA Y + + LGGV + L D+ G Sbjct: 384 DDAESFKYKAKYIKQQQLGGVMFWHLGQDNRNG 416 >4TXG-A nrPDB Length = 793 Score = 230 bits (585), Expect = 1e-60, Method: Composition-based stats. Identities = 91/491 (18%), Positives = 169/491 (34%), Gaps = 104/491 (21%) Query: 20 AASNLVCYYDSSSYTREGLGKLLNPDLEIALQFCSHLVYGYAGLRGEN----LQAYSMNE 75 + ++ Y+ S ++G L +I +H+ Y +A + G N + N Sbjct: 152 SRRRIIGYFTSWRTGKDGSPAYL--ASDIPWSKLTHINYAFAHVDGSNKLSVNETAPGNP 209 Query: 76 NLD---------------IYKHQFSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDL 120 D YK F+ +T KRKYP +K L+SVGG + + Sbjct: 210 ATDMSWPGVAGAEMDASLPYKGHFNLLTQYKRKYPGVKTLISVGGWAETGGYFDANGKRV 269 Query: 121 LEG-------------EKVRQIGFIRSAYDLVKTYGFDGLDLAYQFPKNKPRKVHGDLGL 167 G + F SA ++ YGFDG+D+ +++P + + Sbjct: 270 ASGGFYSMTVNADGTVNQAGINAFSDSAVAFLRKYGFDGVDIDFEYPTSMNNAGNPLDW- 328 Query: 168 AWKSIKKLFTGDFIVDPHAALHKEQFTALVRDVKDSLR----ADGFLLSLTVLPNVNSTW 223 + + + AL++ ++D L DG +T + Sbjct: 329 ------------TFSNARLGSLNKGYVALLQTLRDRLDRAAAQDGRYYQITAAVPASGYL 376 Query: 224 YFDIPALN--GLVDFVNLATFDFLTPARNPEEADYSAPIYHPDGS-------------KD 268 + +DFVN+ ++D +A +Y Sbjct: 377 LRGMETFQGLKYLDFVNVMSYDLHGAWN--RFVGPNAALYDDGKDAELAFWNVYSTPQYG 434 Query: 269 RLAHLNADFQVEYWLSQGFPSNKINLGVATYGNAWKLTKD--SGLEGVPVVPETSGPAPE 326 + +LN D+ Y+ G P++++N+GV Y WK +GL G V P Sbjct: 435 NIGYLNTDWAYHYY-RGGLPASRVNMGVPYYTRGWKNVSGGSNGLWGSSVGSN----CPA 489 Query: 327 GFQSQKPGLLSYAEICGKLSNPQNQFLKGNESPLRRVSD--------------------- 365 G G + I L + + + G +P+ + Sbjct: 490 GLTECGDGAVGIDNIWHDLDDSGKE-IPGGSNPMWHAKNLEKGLAGSYLAAYGIDPTLPI 548 Query: 366 ------PTKRFGGIAYRPVDGQITEGIWVSYDDPDSASNKAAYARVKNLGGVALFDLSYD 419 + + G P + +++S +D S + KAA+ N+GGV ++L+ D Sbjct: 549 NQLTGSYQRNYNGALAAPWLWNAGKKVFLSTEDEQSIAQKAAWIDANNVGGVMFWELAGD 608 Query: 420 -DFRGQCSGDK 429 D++ Q + + Sbjct: 609 YDWKAQRNNGQ 619 >4URI-A nrPDB Length = 337 Score = 227 bits (579), Expect = 7e-60, Method: Composition-based stats. Identities = 85/380 (22%), Positives = 134/380 (35%), Gaps = 73/380 (19%) Query: 47 EIALQFCSHLVYGYAGLRGENLQAYSMNENLDIYKHQFSEVT-SLKRKYPHLKVLLSVGG 105 +I +HL +A L + + N FS T +++ K P +K LLS+ Sbjct: 17 DINPSHFTHLFCAFADLDPNTNKLTISSSNA----AAFSTFTQTVRAKNPSVKTLLSI-- 70 Query: 106 DHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDLVKTYGFDGLDLAYQFPKNKPRKVHGDL 165 + + R+ FI S+ L + F GLDL +++P + Sbjct: 71 -GGGGGRALAAVFANMASQASRRKSFIDSSIQLARRNNFHGLDLDWEYPSS--------- 120 Query: 166 GLAWKSIKKLFTGDFIVDPHAALHKEQFTALVRDVKDSLRADGFLLSLTVLPN--VNSTW 223 I K I + AA+ E T+ LLS V + + Sbjct: 121 -----DIDKTNFASLIREWRAAVATESSTS---------GTPALLLSAAVGGSDQITPLK 166 Query: 224 YFDIPALNGLVDFVNLATFDFLTPARNPEEADYSAPIYHPDGSKDRLAHLNADFQVEYWL 283 Y+ A+ +D+VN+ T+D T P AP+++P G +AD + W+ Sbjct: 167 YYPGEAIANNLDWVNVMTYDLYTSDSYPTLTQPPAPLFYPRGI------FSADEGITKWI 220 Query: 284 SQGFPSNKINLGVATYGNAWKLTKDSGLEGVPVVPETSGPAPEGFQSQKPGLLSYAEICG 343 G P +K+ LG+ YG W+L D G+ +Q G + Y +I Sbjct: 221 QSGVPESKLALGLPFYGFKWRL-SDPNNHGLFAPA-----------TQGLGAVKYKDIVN 268 Query: 344 KLSNPQNQFLKGNESPLRRVSDPTKRFGGIAYRPVDGQITEGIWVSYDDPDSASNKAAYA 403 G + RF G W YDD S S K AYA Sbjct: 269 ----------TGGQVEFDSTYVTNYRFKGT------------DWYGYDDTQSISAKVAYA 306 Query: 404 RVKNLGGVALFDLSYDDFRG 423 + + L G + + D Sbjct: 307 KQRGLFGYFAWHIEQDSNWA 326 >4W5U-B nrPDB Length = 408 Score = 211 bits (537), Expect = 5e-55, Method: Composition-based stats. Identities = 82/431 (19%), Positives = 142/431 (32%), Gaps = 89/431 (20%) Query: 16 ASTEAASNLVCYYDSSSYTREGLGKLLNPDLEIALQFCSHLVYGYAGLRG---------- 65 A+ + + + Y+ + + N D +H+ Y + + G Sbjct: 35 AAADNGTVKLGYFTEWGTY-DRNFNVKNLDTSGTAAKITHINYAFGNVTGGKCAIGDSYA 93 Query: 66 --------ENLQAYSMNENLDIYKHQFSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKY 117 + + + + F+++ LK KYPH+KVL S GG + Sbjct: 94 DYDKAFTADQSVSGQADTWDQPLRGNFNQLRQLKAKYPHIKVLWSFGGWT-----WSGGF 148 Query: 118 IDLLEGEKVRQIGFIRSAYDLV---KTYG-FDGLDLAYQFPKNKPRKVHGDLGLAWKSIK 173 D + + GF +S Y+LV + G FDG+D+ +++P GL S Sbjct: 149 ADAAKDPQ----GFAQSCYNLVHDPRWDGVFDGIDIDWEYPNA--------CGLTCDSSG 196 Query: 174 KLFTGDFIVDPHAALHKEQFTALVRDVKDSLRADGFLLSLTVLPNVNSTWYFDIPALNGL 233 + + + E TA V D Sbjct: 197 PDAFRNLMAALRSTFGDELVTAAVT---------------ADGTPGGKIEATDYAGAAQY 241 Query: 234 VDFVNLATFDFLTPARNPEEADYSAPIYHPDGSKDRLAHLNADFQVEYWLSQGFPSNKIN 293 VD+ N+ T+DF +P+ DG + + + + +QG P++K+ Sbjct: 242 VDWYNVMTYDFFGAWDAQGPTAPHSPLTSYDGIPKQ--GFTSADAIAAFKAQGVPADKLL 299 Query: 294 LGVATYGNAWKLTKDSGLEGVPVVPETSGPAPEGFQSQKPGLLSYAEICGKLSNPQNQFL 353 LG+ YG W G P + + G+ Y + Sbjct: 300 LGIGFYGRGWTGVTQDAPGGTATGPAAG--------TWEQGIEDYKVL------------ 339 Query: 354 KGNESPLRRVSDPTKRFGGIAYRPVDGQITEGIWVSYDDPDSASNKAAYARVKNLGGVAL 413 + T G AY +W SYD PD+ ++K A+A + L G Sbjct: 340 -------KNTCPVTGTVAGTAYA----HCGSNLW-SYDTPDTIASKMAWANDQGLRGAFA 387 Query: 414 FDLSYDDFRGQ 424 +D S D G+ Sbjct: 388 WDFSGDTADGE 398 >1KFW-A nrPDB Length = 435 Score = 205 bits (522), Expect = 3e-53, Method: Composition-based stats. Identities = 89/468 (19%), Positives = 148/468 (31%), Gaps = 124/468 (26%) Query: 15 AASTEAASNLVCYYDSSSYTREGLGKLLNP---DLEIALQFCSHLVYGYAGLRGENLQAY 71 ST V Y+ G+ D+ + +H+ Y + + + L + Sbjct: 2 LTSTVNGYRNVGYFAQWGVY----GRAFQAKQLDVSGTAKNLTHINYSFGNINNQTLTCF 57 Query: 72 SMN-----------------------------------ENLDIYKHQFSEVTSLKRKYPH 96 N F+++ LK K P Sbjct: 58 MANKAQGTGPNGSDGAGDAWADFGMGYAADKSVSGKADTWDQPLAGSFNQLKQLKAKNPK 117 Query: 97 LKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDLVKTYG------------- 143 LKV++S+GG + E RQ + S DL Sbjct: 118 LKVMISLGGWT-----WSKNFSKAAATEASRQ-KLVSSCIDLYIKGNLPNFEGRGGAGAA 171 Query: 144 ---FDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTALVRDV 200 FDG+D+ +++P + GLA + + + F AL+ + Sbjct: 172 AGIFDGIDIDWEWPGT-------NSGLAGNGVDTVN------------DRANFKALLAEF 212 Query: 201 KDSLRADG------FLLSLTVLPNVNSTW--YFDIPALNGLVDFVNLATFDFLTPARNPE 252 + L A G ++LS + N +D PA +DF ++ +D NP Sbjct: 213 RKQLDAYGSTNNKKYVLSAFLPANPADIDAGGWDDPANFKSLDFGSIQGYDLHGAW-NPT 271 Query: 253 EADYSAPIYHPDGSK-DRLAHLNADFQVEYWLSQGFPSNKINLGVATYGNAWKLTKDSGL 311 + A +Y +AD V+ +L+ G ++ LG+A YG W K+ Sbjct: 272 LTGHQANLYDDPADPRAPSKKFSADKAVKKYLAAGIDPKQLGLGLAAYGRGWTGAKNVSP 331 Query: 312 EGVPVVPETSGPAPEGFQSQKPGLLSYAEICGKLSNPQNQFLKGNESPLRRVSDPTKRFG 371 G + AP +++ +N LK +D Sbjct: 332 WG-----PATDGAPGTYET---------------ANEDYDKLK------TLGTDHYDAAT 365 Query: 372 GIAYRPVDGQITEGIWVSYDDPDSASNKAAYARVKNLGGVALFDLSYD 419 G A+R W SYD+ + K Y K LGG ++LS D Sbjct: 366 GSAWRYD-----GTQWWSYDNIATTKQKTDYIVSKGLGGGMWWELSGD 408 >5XWF-A nrPDB Length = 378 Score = 192 bits (487), Expect = 3e-49, Method: Composition-based stats. Identities = 76/381 (19%), Positives = 132/381 (34%), Gaps = 55/381 (14%) Query: 55 HLVYGYAGLRGENLQAYSMNENLDIYKHQFSEVTSLKRKYPHLKVLLSVGGDHDIDPDHP 114 H+VY +A + + + L + + LSVGG Sbjct: 24 HIVYAFAEPTKDGELSGFTDSQLKS--------VVQEAHSRGKSISLSVGGWT------G 69 Query: 115 NKYIDLLEGEKVRQIGFIRSAYDLVKTYGFDGLDLAYQFPKNKPRKVHGDLGLAWKSIKK 174 + Y L F+ + D+VK Y DGL+L +++P + G+A S + Sbjct: 70 SLYFSDLLKSSSSFDNFVSNLVDVVKEYDLDGLNLDWEYP-------NSPNGVACNSKDE 122 Query: 175 LFTGDFIVDPHAALHKEQFTALVRDVKDSLRADGFLLSLTVLPNVNSTWYFDIPAL---- 230 + L + +++ L + L + N L Sbjct: 123 N-------------DTANYLKLFKALREKLGSKTILTTAVPTAPFNDENQQPSTKLDDNW 169 Query: 231 NGLVDFVNLATFDFLTPARNPEEADYSAPIYHPDGSKDRLAHLNADFQVEYWLSQGFPSN 290 VD + +D + A +AP+Y+ + + + V+ W++ G P+ Sbjct: 170 ASTVDAFYIMAYDVNGI--RDKNAGANAPLYYSPKVTG-VEPTSGNDAVKAWIAAGIPAE 226 Query: 291 KINLGVATYGNAWKLTKDSGLEGVPVVPETSGPAPEGFQSQKPGLL---SYAEIC-GKLS 346 ++ LGV YG K + P+ T P SQ G A+ C ++ Sbjct: 227 QLVLGVPFYGRVSKTLE-------PITASTGLYVPISQSSQIKGDSTDEKAADPCPNAVA 279 Query: 347 NPQNQFLK---GNESPLRRVSDPTKRFGGIAYRPVDGQITEGIWVSYDDPDSASNKAAYA 403 Q++ E R S + I+ P + +S+DD S +K YA Sbjct: 280 TYSGQYIWRTIAQEGIARNSSGWVTYWDDISKTPYAYSFSGSKVLSFDDAASLQDKVDYA 339 Query: 404 RVKNLGGVALFDLSYDDFRGQ 424 + + LGGV L+ L DD Sbjct: 340 KKQGLGGVMLWSLEMDDDENT 360 >4A5Q-A nrPDB Length = 546 Score = 148 bits (373), Expect = 4e-36, Method: Composition-based stats. Identities = 73/476 (15%), Positives = 144/476 (30%), Gaps = 118/476 (24%) Query: 17 STEAASNLVCYYDSSSYTRE---------------GLGKLLNPDLEIALQFCSHLVYGYA 61 + N++CY+ S + +L PD + L+Y + Sbjct: 67 EDDDDFNVLCYFTDWSQYDPRIINKEIRDTGGRSADILRLNTPDGRPFKR----LIYSFG 122 Query: 62 GLRGE-----------------------------------------------NLQAYSMN 74 GL G+ + Sbjct: 123 GLIGDKKYSADGNASIAVRLGVATDPDDAIANHKGKTIPVDPDGAVLASINCGFTKWEAG 182 Query: 75 ENLDIY-----KHQFSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQI 129 + + Y K L L+ LS+GG + +++ + Sbjct: 183 DANERYNQEKAKGLLGGFRLLHEADKELEFSLSIGGWSMS------GLFSEIAKDEILRT 236 Query: 130 GFIRSAYDLVKTYG-FDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAAL 188 F+ D + + F LD+ +++P + +P++ Sbjct: 237 NFVEGIKDFFQRFPMFSHLDIDWEYPGSIGAG----------------------NPNSPD 274 Query: 189 HKEQFTALVRDVKDSLRADGFLLSLTVLPNVNSTWYFDIPAL-NGLVDFVNLATFDFLTP 247 F L++ + D+ ++ +S+ + +IPAL + V +NL T+DF T Sbjct: 275 DGANFAILIQQITDAKISNLKGISIASSADPAKIDAANIPALMDAGVTGINLMTYDFFTL 334 Query: 248 ARNPEEADYSAPIYHPDGSKDRLAHLNADFQVEYWLS-QGFPSNKINLGVATYGNAWKLT 306 + + IY D + + D V + + + I +G A Y K Sbjct: 335 GDG--KLSHHTNIYRDP--SDVYSKYSIDDAVTHLIDEKKVDPKAIFIGYAGYTRNAKNA 390 Query: 307 KDSGLEGVPVVPETSGPAPEGFQSQKPGLLSYAEI-CGKLSNPQNQFLKG-NESPLRRVS 364 + + E + +Q G Y+ + + F KG + + V Sbjct: 391 TIT----TSIPSEEALKGTYTDANQTLGSFEYSVLEWTDIICHYMDFEKGEGRNGYKLVH 446 Query: 365 DPTKRFGGIAYRPVDGQITEGIWVSYDDPDSASNKAAYARVKNLGGVALFDLSYDD 420 D +A +++S D P S +K Y + K LGG+ ++ D+ Sbjct: 447 DK------VAKADYLYSEATKVFISLDTPRSVRDKGRYVKDKGLGGLFIWSGDQDN 496 >4DWS-C nrPDB Length = 546 Score = 143 bits (360), Expect = 1e-34, Method: Composition-based stats. Identities = 57/328 (17%), Positives = 114/328 (34%), Gaps = 52/328 (15%) Query: 101 LSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDL-VKTYGFDGLDLAYQFPKNKPR 159 S+GG + L E R++ F+ S D V+ F +D+ +++P Sbjct: 216 FSIGGWSLSSY-----FSALAENPDERRV-FVASVVDFFVRFPMFSCVDIDWEYPGGGGD 269 Query: 160 KVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTALVRDVKDSLRAD-----GFLLSLT 214 + + + E + L+++++ +L + +S+ Sbjct: 270 EGNIS---------------------SDKDGENYVLLIKELRSALDSRFGYSNRKEISIA 308 Query: 215 VLPNVNSTWYFDIPAL-NGLVDFVNLATFDFLTPARNPEEADYSAPIYHP-DGSKDRLAH 272 +I L +D + L ++DF + + +Y P D + L Sbjct: 309 CSGVKAKLKKSNIDQLVANGLDNIYLMSYDFFGTI-WADYIGHHTNLYSPKDPGEQELFD 367 Query: 273 LNADFQVEYWLSQ-GFPSNKINLGVATYGNAWKLTKDSGLEGVPVVPETSGPAPEGFQSQ 331 L+A+ ++Y ++ G P KI+LG A YG + + G + + P + Sbjct: 368 LSAEAAIDYLHNELGIPMEKIHLGYANYGRS-------AVGGDLTTRQYTKNGPA-LGTM 419 Query: 332 KPGLLSYAEICGKLSNPQNQFLKGNESPLRRVSDPTKRFGGIAYRPVDGQITEGIWVSYD 391 + G + +I + ++ G + A +G ++S D Sbjct: 420 ENGAPEFFDIVKNYMDAEHSLSMGKNGFVLMT-------DTNADADFLFSEAKGHFISLD 472 Query: 392 DPDSASNKAAYARVKNLGGVALFDLSYD 419 P + K YA LGGV + D Sbjct: 473 TPRTVKQKGEYAAKNKLGGVFSWSGDQD 500 >6OGD-C nrPDB Length = 633 Score = 142 bits (357), Expect = 4e-34, Method: Composition-based stats. Identities = 57/328 (17%), Positives = 114/328 (34%), Gaps = 52/328 (15%) Query: 101 LSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDL-VKTYGFDGLDLAYQFPKNKPR 159 S+GG + L E R++ F+ S D V+ F +D+ +++P Sbjct: 303 FSIGGWSLSSY-----FSALAENPDERRV-FVASVVDFFVRFPMFSCVDIDWEYPGGGGD 356 Query: 160 KVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTALVRDVKDSLRAD-----GFLLSLT 214 + + + E + L+++++ +L + +S+ Sbjct: 357 EGNIS---------------------SDKDGENYVLLIKELRSALDSRFGYSNRKEISIA 395 Query: 215 VLPNVNSTWYFDIPAL-NGLVDFVNLATFDFLTPARNPEEADYSAPIYHP-DGSKDRLAH 272 +I L +D + L ++DF + + +Y P D + L Sbjct: 396 CSGVKAKLKKSNIDQLVANGLDNIYLMSYDFFGTI-WADYIGHHTNLYSPKDPGEQELFD 454 Query: 273 LNADFQVEYWLSQ-GFPSNKINLGVATYGNAWKLTKDSGLEGVPVVPETSGPAPEGFQSQ 331 L+A+ ++Y ++ G P KI+LG A YG + + G + + P + Sbjct: 455 LSAEAAIDYLHNELGIPMEKIHLGYANYGRS-------AVGGDLTTRQYTKNGPA-LGTM 506 Query: 332 KPGLLSYAEICGKLSNPQNQFLKGNESPLRRVSDPTKRFGGIAYRPVDGQITEGIWVSYD 391 + G + +I + ++ G + A +G ++S D Sbjct: 507 ENGAPEFFDIVKNYMDAEHSLSMGKNGFVLMT-------DTNADADFLFSEAKGHFISLD 559 Query: 392 DPDSASNKAAYARVKNLGGVALFDLSYD 419 P + K YA LGGV + D Sbjct: 560 TPRTVKQKGEYAAKNKLGGVFSWSGDQD 587 >4Q6T-A nrPDB Length = 351 Score = 88.3 bits (217), Expect = 6e-18, Method: Composition-based stats. Identities = 50/334 (14%), Positives = 105/334 (31%), Gaps = 72/334 (21%) Query: 92 RKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDLVKTYGFDGLDLAY 151 K L + +V ++ + ++ G ++ L K GF G++L + Sbjct: 62 AKSQSLPLYPTVSDYNEDIGAFDPAISHSILNDRALSAGTVKQLVKLAKEGGFAGINLDF 121 Query: 152 QFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTALVRDVKDSLRADGFLL 211 + ++ F A V+ + ++L A L Sbjct: 122 E-------------------------------KVEPRNRAAFCAFVKTLGNALHASNKKL 150 Query: 212 SLTVLPN-----VNSTWYFDIPALNGLVDFVNLATFDFLTPARNPEEADYSAPIYHPDGS 266 +++ P +D AL VD+ + T+D + P + +H + Sbjct: 151 IISIPPKLSDTEPEYLQGYDYKALGAAVDYFQVMTYDQVGPGWSSGG-------FHNEAW 203 Query: 267 KDRLAHLNADFQVEYWLSQGFPSNKINLGVATYGNAWKLTKDSGLEGVPVVPETSGPAPE 326 + + + + P++K+ G+ TYG + + + + Sbjct: 204 PGPESGFDWQQALLSYAVSRVPASKVLAGLPTYGQDYSI--GNRVHWS------------ 249 Query: 327 GFQSQKPGLLSYAEICGKLSNPQNQFLKGNESPLRRVSDPTKRFGGIAYRPVDGQITEGI 386 +Y EI + + +P G+ + P Q + Sbjct: 250 ----------AYQEIIAEHR-AAIHRDAASATPYATWGPVKSFVDGVEWTPERAQPV--L 296 Query: 387 WVSYDDPDSASNKAAYARVKNLGGVALFDLSYDD 420 W YDD S K A LGG +++ + Y++ Sbjct: 297 W--YDDAASIKTKTALVTRLGLGGTSVWAMGYEN 328 >4WIW-A nrPDB Length = 349 Score = 86.0 bits (211), Expect = 3e-17, Method: Composition-based stats. Identities = 61/379 (16%), Positives = 117/379 (30%), Gaps = 81/379 (21%) Query: 61 AGLRGENLQAYSMNENLDIYKHQFSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDL 120 + + +E YK + L +KVL + G L Sbjct: 43 GSIGTDGSLKLVWDEGSSNYKQLTNMAHGL-----GMKVLPLINGSGATLNT-------L 90 Query: 121 LEGEKVRQIGFIRSAYDLVKTYGFDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDF 180 L+ R+ I L+K DG+ + ++ P + G+ Sbjct: 91 LKSPAARE-KLIGEIVVLLKNTNADGVVIDFETPLDYGDVKDPYDGV------------- 136 Query: 181 IVDPHAALHKEQFTALVRDVKDSLRADGFLLSLTVLPNVNSTWY----FDIPALNGLVDF 236 + TA + + L++ L+ + V+P ++S+ Y +D AL+ VD+ Sbjct: 137 ---------RNDLTAFMESLHSELQSMNKLVVMAVMPRMSSSQYWLDAYDYEALSHAVDY 187 Query: 237 VNLATFDFLTPARNPEEADYSAPIYHPDGSKDRLAHLNADFQVEYWLSQGFPSNKINLGV 296 +++ T+D PI K + Y QG +K+ +G+ Sbjct: 188 LHVMTYDHHY------RTSAPGPIAPYPWIK---------QVLTYIQGQGVDMSKVLMGI 232 Query: 297 ATYGNAWKLTKDSGLEGVPVVPETSGPAPEGFQSQKPGLLSYAEICGKLSNPQNQFLKGN 356 YG W + G P + S G E+ G Sbjct: 233 PYYGRDW-VVDGKDANGNP-----------TYNSTAFGYSKALELADSY---------GA 271 Query: 357 ESPLRRVSDPTKRFGGIAYRPVDGQITEGIWVSYDDPDSASNKAAYARVKNLGGVALFDL 416 + +D + + ++ +DD S + K + L GV + + Sbjct: 272 TITYSKYNDADPVGTPTFKYTDEKGVEHTVF--FDDYTSWNAKLSIINEFGLAGVGPWAM 329 Query: 417 S-YDDFRGQCSGDKYPILR 434 D+ + +P+L Sbjct: 330 GWVDENTAE---GLFPLLN 345 >3CZ8-A nrPDB Length = 319 Score = 81.8 bits (200), Expect = 5e-16, Method: Composition-based stats. Identities = 54/314 (17%), Positives = 103/314 (32%), Gaps = 84/314 (26%) Query: 107 HDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDLVKTYGFDGLDLAYQFPKNKPRKVHGDLG 166 + + + + + + + YDLV T G+ G+ + ++ Sbjct: 75 NLTSGGFSTEIVHQVLNNPTARTNLVNNIYDLVSTRGYGGVTIDFE-------------- 120 Query: 167 LAWKSIKKLFTGDFIVDPHAALHKEQFTALVRDVKDSLRADGFLLSLTVLP----NVNST 222 +A ++ FT +R ++D L+A G++L++ V N+ Sbjct: 121 -----------------QVSAADRDLFTGFLRQLRDRLQAGGYVLTIAVPAKTSDNIPWL 163 Query: 223 WYFDIPALNGLVDFVNLATFDFLTPARNPEEADYSAPIYHPDGSKDRLAHLNADFQVEYW 282 +D + +V+++ + +D+ P API +E+ Sbjct: 164 RGYDYGGIGAVVNYMFIMAYDWHHAGSEP---GPVAPITE------------IRRTIEFT 208 Query: 283 LSQGFPSNKINLGVATYGNAWKLTKDSGLEGVPVVPETSGPAPEGFQSQKPGLLSYAEIC 342 ++Q PS KI +GV YG W + G + Q+ + Y Sbjct: 209 IAQ-VPSRKIIIGVPLYGYDWIIPYQPGTVASAISN----------QNAIERAMRY---- 253 Query: 343 GKLSNPQNQFLKGNESPLRRVSDPTKRFGGIAYRPVDGQITEGIWVSYDDPDSASNKAAY 402 Q+ +SP R SD R T +W ++ S S K Sbjct: 254 ----QAPIQYSAEYQSPFFRYSDQQGR-------------THEVW--FEGVRSMSRKMQI 294 Query: 403 ARVKNLGGVALFDL 416 R L + + L Sbjct: 295 VREYRLQAIGAWQL 308 >3CO4-A nrPDB Length = 312 Score = 72.9 bits (177), Expect = 3e-13, Method: Composition-based stats. Identities = 56/373 (15%), Positives = 112/373 (30%), Gaps = 113/373 (30%) Query: 48 IALQFCSHLVYGYAGLRGENLQAYSMNENLDIYKHQFSEVTSLKRKYPHLKVLLSVGGDH 107 I ++ +H+ +A ++ + N++ + + V K+ ++K+L+S+ Sbjct: 24 IEWKYLTHINASFARVKADGTL------NINPVRKRIESVRETAHKH-NVKILISL---- 72 Query: 108 DIDPDHPNKYIDLLEGEKVRQIGFIRSAYDLVKTYGFDGLDLAYQFPKNKPRKVHGDLGL 167 + P ++ + K R+ I+ K Y DG D+ Y+ Sbjct: 73 --AKNSPGEFTTAINDPKARK-ELIQQIIAFTKEYKLDGFDIDYE--------------- 114 Query: 168 AWKSIKKLFTGDFIVDPHAALHKEQFTALVRDVKDSLRADGFLLSLTVLPNVNSTWYFDI 227 + + K F + L KE L++ V + Sbjct: 115 EYDNWDKNFPSLLVFARGLYLAKE---------------KNMLMTCAVNSRWLNYG---- 155 Query: 228 PALNGLVDFVNLATFDFLTPARNPEEADYSAPIYHPDGSKDRLAHLNADFQVEYWLSQ-G 286 D++NL ++D D ++YW Q Sbjct: 156 TEWEQYFDYINLMSYD-------------RGAFTDKPVQHASYDDFVKD--LKYWNEQCR 200 Query: 287 FPSNKINLGVATYGNAWKLTKDSGLEGVPVVPETSGPAPEGFQSQKPGLLSYAEICGKLS 346 +KI G+ YG +W+ + +G G+ Y+ I L Sbjct: 201 ASKSKIVGGLPFYGYSWE------------------ESLQGAVDDVRGI-RYSGILKHL- 240 Query: 347 NPQNQFLKGNESPLRRVSDPTKRFGGIAYRPVDGQITEGIWVSYDDPDSASNKAAYARVK 406 GNE+ + T Y+ + +NK + + Sbjct: 241 --------GNEAADKDNIGKTY---------------------YNGRPTIANKCKFIKEN 271 Query: 407 NLGGVALFDLSYD 419 + GV ++ L D Sbjct: 272 DYAGVMIWQLFQD 284 >4S3K-A nrPDB Length = 436 Score = 69.1 bits (167), Expect = 3e-12, Method: Composition-based stats. Identities = 43/246 (17%), Positives = 74/246 (30%), Gaps = 54/246 (21%) Query: 180 FIVDPHAALHKEQFTALVRDVKDSLRADGFLLSLTVLPNVNS------TWYFDIPALNGL 233 F + KE + A ++ K L+ + L+S+ + P + D A+ + Sbjct: 218 FDFEFLRPADKEAYIAFLQKAKKRLQDEQLLMSVALAPKTSRDQKGKWYEAHDYKAIGEI 277 Query: 234 VDFVNLATFDFLTPARNPEEADYSAPIYHPDGSKDRLAHLNADFQVEYWLSQGFPSNKIN 293 +FV T+++ P P+ ++ V PS+KI Sbjct: 278 ANFVVPMTYEWGYSGGPPMAVSPIGPVRDV-----------LEYAVSE-----IPSSKII 321 Query: 294 LGVATYGNAWKLTKDSGLEGVPVVPETSGPAPEGFQSQKPGLLSYAEICGKLSNPQNQFL 353 +G YG W L G E + Q+ Sbjct: 322 MGQNLYGYDWTLPYKPGGEYAKAISPQRAIELAARY-----------------KVAIQYD 364 Query: 354 KGNESPLRRVSDPTKRFGGIAYRPVDGQITEGIWVSYDDPDSASNKAAYARVKNLGGVAL 413 ++P R D Q T +W ++D S K + L G+A Sbjct: 365 NKAQAPFFRYKDEQ-------------QRTHEVW--FEDARSIQAKFDLIKELKLRGMAY 409 Query: 414 FDLSYD 419 + L D Sbjct: 410 WKLGLD 415 >5JH8-A nrPDB Length = 317 Score = 67.5 bits (163), Expect = 1e-11, Method: Composition-based stats. Identities = 49/319 (15%), Positives = 99/319 (31%), Gaps = 92/319 (28%) Query: 108 DIDPDHPNKYIDLLEGEKVRQIGFIRSAYDLVKTYGFDGLDLAYQFPKNKPRKVHGDLGL 167 D + + + Q + + + F G+++ ++ Sbjct: 71 DGNGNWSADIAHAVSTSAQSQA--VANLVKFAQDKRFSGINVDFE--------------- 113 Query: 168 AWKSIKKLFTGDFIVDPHAALHKEQFTALVRDVKDSLRADGFLLSLTVLP------NVNS 221 A + F+ ++ + +L A G L ++V N + Sbjct: 114 ----------------AVAQGDRNNFSHFIQVLGRALHAKGLKLIVSVPAFSAKDENHPA 157 Query: 222 TWYFDIPALNGLVDFVNLATFDFLTPARNPEEADYSAPIYHPDGSKDRLAHLNADFQVEY 281 + +D+ AL D++ + ++D PA +P P+ D +D L D+ VE Sbjct: 158 NYGYDLRALGAAADYLQIMSYDEAIPAWDP------GPVAGSDWMEDDL-----DYAVER 206 Query: 282 WLSQGFPSNKINLGVATYGNAWKLTKDSGLEGVPVVPETSGPAPEGFQSQKPGLLSYAEI 341 P+ KI G+ YG WK D G+ ++ + + Y Sbjct: 207 -----VPAAKILNGIPAYGYDWKRPGDGGM--------------LYWKDTQALIARYGAQ 247 Query: 342 CGKLSNPQNQFLKGNESPLRRVSDPTKRFGGIAYRPVDGQITEGIWVSYDDPDSASNKAA 401 + + + R + T ++ S + KA+ Sbjct: 248 PRYDAGTHSLTFNYGAADGSRHTVWT-----------------------ENARSVALKAS 284 Query: 402 YARVKNLGGVALFDLSYDD 420 LGG +L+ L +D Sbjct: 285 LVNAYGLGGTSLYALGMED 303 >4S3J-A nrPDB Length = 433 Score = 65.6 bits (158), Expect = 4e-11, Method: Composition-based stats. Identities = 45/245 (18%), Positives = 82/245 (33%), Gaps = 55/245 (22%) Query: 180 FIVDPHAALHKEQFTALVRDVKDSLRADGFLLSLTVLPNVNST------WYFDIPALNGL 233 F + A +E + +R+VK L G+ LS T++P +S D A + Sbjct: 217 FDFESVAPEDREAYNRFLRNVKIRL-PSGYTLSTTLVPKTSSNQKGKFFEAHDYKAQGQI 275 Query: 234 VDFVNLATFDFLTPARNPEEADYSAPIYHPDGSKDRLAHLNADFQVEYWLSQGFPSNKIN 293 VDFV + T+D+ + P + + + +V + P KI Sbjct: 276 VDFVVIMTYDW--GWQGG-----------PPMAISPIGPV---KEVLQYAKSQMPPQKIM 319 Query: 294 LGVATYGNAWKLTKDSGLEGVPVVPETSGPAPEGFQSQKPGLLSYAEICGKLSNPQNQFL 353 +G YG WKL G V + A + Sbjct: 320 MGQNLYGFDWKLPFKQGNPPAKAVSSVAAVALARKYN----------------------- 356 Query: 354 KGNESPLRRVSDPTKRFGGIAYRPVDGQITEGIWVSYDDPDSASNKAAYARVKNLGGVAL 413 + D T + Y +G + +W ++D S +K + + +GG++ Sbjct: 357 ------VPIRYDFTAQAPHFNYFDENG-VQHEVW--FEDARSIQSKFNLMKEQGIGGISY 407 Query: 414 FDLSY 418 + + Sbjct: 408 WKIGL 412 >3SIM-A nrPDB Length = 275 Score = 56.4 bits (134), Expect = 2e-08, Method: Composition-based stats. Identities = 24/143 (16%), Positives = 50/143 (34%), Gaps = 5/143 (3%) Query: 64 RGENLQAYSMNENLDIYKHQFSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEG 123 N D +++++K +P+++V +S+GG N Sbjct: 43 SPHTSTNGKFNVFWDSSILGPDQISAIKSSHPNVRVAVSLGGASV----GSNTVQFQAAS 98 Query: 124 EKVRQIGFIRSAYDLVKTYGFDGLDLAYQ-FPKNKPRKVHGDLGLAWKSIKKLFTGDFIV 182 + S +++ Y DG+D+ Y+ F +G ++KK F Sbjct: 99 VDSWVSNAVTSLTRIIQRYNLDGIDIDYEHFQNTDKNTFAECIGRLITTLKKNGVISFAS 158 Query: 183 DPHAALHKEQFTALVRDVKDSLR 205 E + AL + K+++ Sbjct: 159 ISPFPSVDEYYLALFNEYKNAIN 181 >4RL3-A nrPDB Length = 272 Score = 53.7 bits (127), Expect = 2e-07, Method: Composition-based stats. Identities = 44/254 (17%), Positives = 79/254 (31%), Gaps = 17/254 (6%) Query: 34 TREGLGKLLNP----DLEIALQFCSHLVYGYAGLRGENLQAYSMNENLDIYKHQF----S 85 RE +G L N D+ I H + +A A + N +IY + Sbjct: 4 FREYIGALYNGVQFTDVPINSGVTFHFILAFAI--DYTSAAAATNGVFNIYWQNSVLTPA 61 Query: 86 EVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDLVKTYGFD 145 V ++K ++ ++KV++S+GGD + + S L+ Y D Sbjct: 62 AVQAIKAQHSNVKVMVSLGGDTIS----GSPVQFTATSVSSWVANAVSSLTSLINQYHLD 117 Query: 146 GLDLAYQ-FPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTALVRDVKDSL 204 G+D+ Y+ F + +G +K + Q+TAL + Sbjct: 118 GIDIDYEHFDQVSTSTFVSCIGQLITQLKANNVISVASIAPFDGVESQYTALFGQYSSVI 177 Query: 205 R--ADGFLLSLTVLPNVNSTWYFDIPALNGLVDFVNLATFDFLTPARNPEEADYSAPIYH 262 F ++ A LA+F P + Sbjct: 178 DLVNFQFYSYGAGTSASQYVSLYNTAASKYGGGAKVLASFSTGGVGPAPSTVLSACQQLK 237 Query: 263 PDGSKDRLAHLNAD 276 G+ + +AD Sbjct: 238 SSGTLPGIFIFSAD 251 >4TX8-A nrPDB Length = 439 Score = 49.4 bits (116), Expect = 3e-06, Method: Composition-based stats. Identities = 20/97 (20%), Positives = 40/97 (41%), Gaps = 12/97 (12%) Query: 56 LVYGYAGLRGENLQAYSMNENLDIYKHQFSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPN 115 +V +A G +++++ ++ + + K KV+LS+GG + Sbjct: 136 IVVAFADDAGNGNVSFTLDPAAGSAAQFIQDIRAQQAK--GKKVVLSLGGQNGSVTL--- 190 Query: 116 KYIDLLEGEKVRQIGFIRSAYDLVKTYGFDGLDLAYQ 152 + F+ S Y ++ YGFDG+DL + Sbjct: 191 -------NNATQVQNFVNSLYGILTQYGFDGIDLDLE 220 >1NAR-A nrPDB Length = 290 Score = 48.3 bits (113), Expect = 6e-06, Method: Composition-based stats. Identities = 24/106 (22%), Positives = 45/106 (42%), Gaps = 15/106 (14%) Query: 55 HLVYGYA--GLRGENLQAYSMNENLDIYKHQFSEVTSLKRKYPHLKVLLSVGGDHDIDPD 112 H + G+A + E+ D+ +V +LKR++P +KV++S+GG P Sbjct: 34 HYILGFAIESYYESGKGTGTFEESWDVELFGPEKVKNLKRRHPEVKVVISIGGRGVNTPF 93 Query: 113 HPNKYIDLLEGEKVRQIGFIRSAYDLVKTYG------FDGLDLAYQ 152 P + + K S +++ Y DG+D+ Y+ Sbjct: 94 DPAEENVWVSNAK-------ESLKLIIQKYSDDSGNLIDGIDIHYE 132 >3EBV-A nrPDB Length = 302 Score = 47.9 bits (112), Expect = 1e-05, Method: Composition-based stats. Identities = 15/55 (27%), Positives = 25/55 (45%), Gaps = 10/55 (18%) Query: 98 KVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDLVKTYGFDGLDLAYQ 152 KV++SVGG+ + F S Y +++ YGFDG+D+ + Sbjct: 77 KVIISVGGEKGT----------VSVNSSASATNFANSVYSVMREYGFDGVDIDLE 121 >2Y8V-A nrPDB Length = 290 Score = 46.4 bits (108), Expect = 3e-05, Method: Composition-based stats. Identities = 26/132 (19%), Positives = 53/132 (40%), Gaps = 13/132 (9%) Query: 23 NLVCYYDSSSYTREGLGKLLNPDLEIALQFCSHLVYGYAGLRGENLQAYSMNENLD--IY 80 ++CY+ + R +L L +H++ L + ++ D +Y Sbjct: 14 RVICYHQTLCPNRGDYVSVLP--LVKNNTGVTHIIIAAFHLNEDPGHITLNDDPPDHEMY 71 Query: 81 KHQFSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDLVK 140 ++EV LKR +KV+ +GG L+G++ + + + +V+ Sbjct: 72 NPLWAEVPVLKRS--GVKVMGMLGG-------AAQGSYRCLDGDQEKFERYYQPLLAMVR 122 Query: 141 TYGFDGLDLAYQ 152 + DGLDL + Sbjct: 123 RHQLDGLDLDVE 134 >4W5Z-A nrPDB Length = 345 Score = 46.0 bits (107), Expect = 3e-05, Method: Composition-based stats. Identities = 36/285 (12%), Positives = 92/285 (32%), Gaps = 54/285 (18%) Query: 24 LVCYYDSSSYTREGLGKLLNPDLEIALQFCSH------LVYGYA---GLRGENLQAYSMN 74 +V Y+ + G+ ++ + + + + + + ++ Sbjct: 33 VVGYWHNWC-----DGRGYQGGNAPCVELKTVNPQYNVVNISFMKVYDIAEGRIPTFKLD 87 Query: 75 ENLDIYKHQF-SEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIR 133 + + + +F +++ +L + VL+++GG +E + + Sbjct: 88 PTIALSEAEFIAQIDTLNSQGRS--VLIALGGADAH-----------IELTRGDEDALAA 134 Query: 134 SAYDLVKTYGFDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQF 193 L YGFDGLD+ + ++ F++ + KE + Sbjct: 135 EIIRLTDLYGFDGLDIDLE-----------------QAAITAKDNQFVIPAALKMVKEHY 177 Query: 194 TALVRDVKDSLRADGFLLSLTVLPNVNSTWYFDIPALNGLVDFVNLATFDFLTPARNPEE 253 + ++ + L+ + L+G DF+N ++ E Sbjct: 178 RKTGDNFMITMAPEFPYLTANGAYTPY------LTELDGYYDFINPQFYNQGGDGLWIEG 231 Query: 254 ADYSAPIYHPDGSKDRLAHLNADFQVEYWLS-QGFPSNKINLGVA 297 + A + D K+ + AD + + P +K+ G+ Sbjct: 232 VGWIAQ--NNDALKEEFIYYIADSLINGTRNYHKIPHDKLVFGLP 274 >3BXW-B nrPDB Length = 393 Score = 45.2 bits (105), Expect = 5e-05, Method: Composition-based stats. Identities = 27/175 (15%), Positives = 59/175 (33%), Gaps = 31/175 (17%) Query: 150 AYQFPK-----NKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTALVR---DVK 201 + + + ++ + K F+V+ L ++ L+ + Sbjct: 154 DWTYDDFRNVLDSEDEIEELSKTVVQVAKNQHFDGFVVEVWNQLLSQKRVGLIHMLTHLA 213 Query: 202 DSLRADGFLLSLTVLPNVNSTW-------YFDIPALNGLVDFVNLATFDFLTPARNPEEA 254 ++L L L + P + + + L ++D +L T+D+ T + Sbjct: 214 EALHQARLLALLVIPPAITPGTDQLGMFTHKEFEQLAPVLDGFSLMTYDYSTA----HQP 269 Query: 255 DYSAPIYHPDGSKDRLAHLNADFQVEYWLSQGFPSNKINLGVATYGNAWKLTKDS 309 +AP+ A + W +KI LG+ YG + +KD+ Sbjct: 270 GPNAPL------SWVRACVQVLDPKSKWR------SKILLGLNFYGMDYATSKDA 312 >4MB4-A nrPDB Length = 528 Score = 44.8 bits (104), Expect = 8e-05, Method: Composition-based stats. Identities = 36/285 (12%), Positives = 91/285 (31%), Gaps = 54/285 (18%) Query: 24 LVCYYDSSSYTREGLGKLLNPDLEIALQFCSH------LVYGYA---GLRGENLQAYSMN 74 +V Y+ + G+ ++ + + + + + + ++ Sbjct: 11 VVGYWHNWC-----DGRGYQGGNAPCVELKTVNPQYNVVNISFMKVYDIAEGRIPTFKLD 65 Query: 75 ENLDIYKHQF-SEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIR 133 + + + +F +++ +L + VL+++GG +E + + Sbjct: 66 PTIALSEAEFIAQIDTLNSQGRS--VLIALGGADAH-----------IELTRGDEDALAA 112 Query: 134 SAYDLVKTYGFDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQF 193 L YGFDGLD+ ++ F++ + KE + Sbjct: 113 EIIRLTDLYGFDGLDID-----------------LQQAAITAKDNQFVIPAALKMVKEHY 155 Query: 194 TALVRDVKDSLRADGFLLSLTVLPNVNSTWYFDIPALNGLVDFVNLATFDFLTPARNPEE 253 + ++ + L+ + L+G DF+N ++ E Sbjct: 156 RKTGDNFMITMAPEFPYLTANGAYTPY------LTELDGYYDFINPQFYNQGGDGLWIEG 209 Query: 254 ADYSAPIYHPDGSKDRLAHLNADFQVEYWLS-QGFPSNKINLGVA 297 + A + D K+ + AD + + P +K+ G+ Sbjct: 210 VGWIAQ--NNDALKEEFIYYIADSLINGTRNYHKIPHDKLVFGLP 252 >3IAN-A nrPDB Length = 321 Score = 42.5 bits (98), Expect = 4e-04, Method: Composition-based stats. Identities = 37/210 (17%), Positives = 69/210 (32%), Gaps = 56/210 (26%) Query: 99 VLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDLVKTYGFDGLDLAYQFPKNKP 158 VL+++GG +E +K ++ F+ LV TYGFDGLD+ + Sbjct: 82 VLIALGGADAH-----------IELKKSQESDFVNEIIRLVDTYGFDGLDIDLE------ 124 Query: 159 RKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTALVRDVKDSLRADGFLLSLTVLPN 218 AA ++ + ++ VKD R DG +T+ P Sbjct: 125 ----------------------QAAIEAADNQTVIPSALKKVKDHYRKDGKNFMITMAPE 162 Query: 219 VNSTWYFDIPA-----LNGLVDFVNLATFDFLTPARNPEEADYSAPIYHPDGSKDRLAHL 273 A L+ DF+N ++ ++ + ++ Sbjct: 163 FPYLTSSGKYAPYINNLDSYYDFINPQYYNQGGDGFWDS----DLNMWISQSNDEKKEDF 218 Query: 274 NADFQVEYWLSQG------FPSNKINLGVA 297 + + L G P++K +G+ Sbjct: 219 --LYGLTQRLVTGTDGFIKIPASKFVIGLP 246 >3N18-A nrPDB Length = 333 Score = 42.1 bits (97), Expect = 5e-04, Method: Composition-based stats. Identities = 28/127 (22%), Positives = 47/127 (37%), Gaps = 19/127 (14%) Query: 24 LVCYYDSSSYTREGLGKLLNPDLEIALQFCSHLVYGYAGLRGENLQAYSMNENLDIYKHQ 83 LV Y G G + D+ + + G+ + Sbjct: 9 LVGY---WHNFDNGTGIIKLKDVSPKWDV---INVSFGETGGDR-STVEFSPVYGTDADF 61 Query: 84 FSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDLVKTYG 143 S+++ LK K KV+LS+GG + + +L + + FI S L+ YG Sbjct: 62 KSDISYLKSK--GKKVVLSIGGQNGV----------VLLPDNAAKDRFINSIQSLIDKYG 109 Query: 144 FDGLDLA 150 FDG+D+ Sbjct: 110 FDGIDID 116 >1EDT-A nrPDB Length = 271 Score = 39.0 bits (89), Expect = 0.004, Method: Composition-based stats. Identities = 36/253 (14%), Positives = 75/253 (29%), Gaps = 44/253 (17%) Query: 38 LGKLLNPDLEIALQFCSHLVYGYAGLRGENLQAYSM--NENLDIYKHQFSEVTSLKRKYP 95 +GK D + + AY + + +++ L+++ Sbjct: 25 VGKYTLADGGGNAFDVAVIFAANINYDTGTKTAYLHFNENVQRVLDNAVTQIRPLQQQ-- 82 Query: 96 HLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDLVKTYGFDGLDLAYQFPK 155 +KVLLSV G+H + + + F + D V YG DG+D ++ Sbjct: 83 GIKVLLSVLGNHQ-----GAGFANFPSQQAASA--FAKQLSDAVAKYGLDGVDFDDEY-- 133 Query: 156 NKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTALVRDVKDSLRADGF-LLSLT 214 ++ + A + F LV ++ ++ L ++ Sbjct: 134 ----------------------AEYGNNGTAQPNDSSFVHLVTALRANMPDKIISLYNIG 171 Query: 215 VLPNVNSTWYFDIPALNGLVDF-VNLATFDFLTPARNPEEADYSAPIYHPDGSKDRLAHL 273 + S D+ D+ N + + P A A + R + Sbjct: 172 PAASRLSYGGVDVSD---KFDYAWN----PYYGTWQVPGIALPKAQLSPAAVEIGRTSRS 224 Query: 274 NADFQVEYWLSQG 286 + +G Sbjct: 225 TVADLARRTVDEG 237 >4AXN-A nrPDB Length = 328 Score = 38.3 bits (87), Expect = 0.006, Method: Composition-based stats. Identities = 49/290 (16%), Positives = 95/290 (32%), Gaps = 69/290 (23%) Query: 24 LVCYYDSSSY-----TREGLGKLLNPDLEIALQFCSHLVYGYAGLRGENLQAYS-MNENL 77 L+ ++ + + ++G +N + V A ++G+ + + N + Sbjct: 27 LMGFWHNWAAGASDGYQQGQFANMNLTDIPT----EYNVVAVAFMKGQGIPTFKPYNLSD 82 Query: 78 DIYKHQFSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYD 137 ++ Q + S R VL+S+GG +E + + Sbjct: 83 TEFRRQVGVLNSQGRA-----VLISLGGADAH-----------IELKTGDEDKLKDEIIR 126 Query: 138 LVKTYGFDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTALV 197 LV+ YGFDGLD+ + AA +K A + Sbjct: 127 LVEVYGFDGLDIDLE----------------------------QAAIGAANNKTVLPAAL 158 Query: 198 RDVKDSLRADGFLLSLTVLPNVNSTWYFDIPALNGLVDFVNLAT--FDFLTPARNPEEAD 255 + VKD A G +++ P + +D++N +DF+ P + D Sbjct: 159 KKVKDHYAAQGKNFIISMAPEFPY-----LRTNGTYLDYINALEGYYDFIAPQYYNQGGD 213 Query: 256 ------YSAPIYH-PDGSKDRLAHLNADFQVEYWLS-QGFPSNKINLGVA 297 +A I D K+ + + V P+ K +G+ Sbjct: 214 GIWVDELNAWITQNNDAMKEDFLYYLTESLVTGTRGYAKIPAAKFVIGLP 263 >1EOM-A nrPDB Length = 290 Score = 35.6 bits (80), Expect = 0.045, Method: Composition-based stats. Identities = 25/167 (14%), Positives = 54/167 (32%), Gaps = 20/167 (11%) Query: 79 IYKHQFSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDL 138 YK +++ SL+ + +KVL ++ D P + I+S Sbjct: 64 SYKDLDTQIRSLQSR--GIKVLQNIDDDVSWQSSKPGGFASAAAYGDA-----IKSIV-- 114 Query: 139 VKTYGFDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTALVR 198 + + DG+ L + KP + G A ++G P F ++ Sbjct: 115 IDKWKLDGISLDIEHSGAKPNPIPTFPGYAATGYNGWYSGSMAATP-------AFLNVIS 167 Query: 199 DVKDSLRADG---FLLSLTVLPNVNSTWYFDIPALNGLVDFVNLATF 242 ++ L + +V W + +++ L ++ Sbjct: 168 ELTKYFGTTAPNNKQLQIASGIDV-YAWNKIMENFRNNFNYIQLQSY 213 >2EBN-A nrPDB Length = 289 Score = 34.4 bits (77), Expect = 0.11, Method: Composition-based stats. Identities = 22/171 (12%), Positives = 55/171 (32%), Gaps = 12/171 (7%) Query: 65 GENLQAYSMNENLDIYKHQFSEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGE 124 + + + + ++ + L+ K +KV+LS+ G+HD + Sbjct: 55 NDKVFVSNNPNVQHLLTNRAKYLKPLQDK--GIKVILSILGNHD--------RSGIANLS 104 Query: 125 KVRQIGFIRSAYDLVKTYGFDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLF--TGDFIV 182 R F + + Y DG+ ++ + G + + + +L T + Sbjct: 105 TARAKAFAQELKNTCDLYNLDGVFFDDEYSAYQTPPPSGFVTPSNNAAARLAYETKQAMP 164 Query: 183 DPHAALHKEQFTALVRDVKDSLRADGFLLSLTVLPNVNSTWYFDIPALNGL 233 + ++ T+ D + A ++ + + P L Sbjct: 165 NKLVTVYVYSRTSSFPTAVDGVNAGSYVDYAIHDYGGSYDLATNYPGLAKS 215 >5M99-B nrPDB Length = 505 Score = 33.3 bits (74), Expect = 0.24, Method: Composition-based stats. Identities = 29/176 (16%), Positives = 63/176 (35%), Gaps = 10/176 (5%) Query: 132 IRSAYDLVKTYGFDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKE 191 + D ++ G D + + P N+ HG + +++K + ++ + E Sbjct: 29 VSQKVDYLRKLGIDAV---WFMPFNEAVSYHGYDITDYYNVEKDYGTMEDLENMIQVLHE 85 Query: 192 QFTALVRDVKDSLRADGFLLSLTVLPNVNSTWYFDIPALN----GLVDFVNLATFDFLTP 247 ++ D+ + +D + N S+ Y+D ++ D + Sbjct: 86 NGIKVIMDLVINHTSDEHPWFKDAVENTTSSPYWDYYIMSLEDHSGQDHWHWKINSKGQK 145 Query: 248 ARNPEEADYSAPIYHPDGSKDRLAHLNADFQVEYWLSQGFPSNKINLGVATYGNAW 303 Y+ P + D K R V++W+S+G +I+ YG +W Sbjct: 146 VWYFGLFGYNMPDLNHDSQKVREE---VKKIVDFWISKGVDGFRIDAAKHIYGWSW 198 >6MDV-A nrPDB Length = 802 Score = 32.1 bits (71), Expect = 0.54, Method: Composition-based stats. Identities = 30/256 (11%), Positives = 74/256 (28%), Gaps = 25/256 (9%) Query: 26 CYYDSSSYTREGLG----KLLNPDLEIALQFCSHLVYGYAGLRGENLQAYSMNENLDIYK 81 Y+ + + R G + + + +++ + + +E D Y Sbjct: 27 GYFRTW-HDRASTGIDGKQQHPENTMAEVPKEVDILFVFHDHTASDSPF--WSELKDSYV 83 Query: 82 HQF-SEVTSLKRKYPHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDLVK 140 H+ + T+L + ++G + +K D + + + V Sbjct: 84 HKLHQQGTALVQ---------TIGVNELNGRTGLSK--DYPDTPEGNKALAAAIVKAFVT 132 Query: 141 TYGFDGLDLA--YQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTALVR 198 G DGLD+ ++F + + +K I +L + + + Sbjct: 133 DRGVDGLDIDIEHEFTNKRTPEEDARALNVFKEIAQLIGKNGSDKSKLLIMDTTLSVENN 192 Query: 199 DVKDSLRADGFLLSLTVLPNVNSTWYFDI--PALNGLVDFVNLATFDFLTPARNPEEADY 256 + + D L + D N ++++ F+ EE+ Sbjct: 193 PIFKGIAEDLDYLLRQYYGSQGGEAEVDTINSDWNQYQNYID--ASQFMIGFSFFEESAS 250 Query: 257 SAPIYHPDGSKDRLAH 272 ++ D Sbjct: 251 KGNLWFDVNEYDPNNP 266 >6Q64-A nrPDB Length = 364 Score = 31.7 bits (70), Expect = 0.58, Method: Composition-based stats. Identities = 30/221 (13%), Positives = 66/221 (29%), Gaps = 25/221 (11%) Query: 124 EKVRQIGFIRSAYDL-------VKTYGFDGLDLAYQ--FPKNKPRKVHGDLGLAWKSIKK 174 E+ Q FI ++ Y DG D+ YQ + + + + + + + Sbjct: 155 EEKGQGNFIEGVKAYANAICDSIEKYNLDGFDIDYQPGYGHSGTLANYQTISPSGNNKMQ 214 Query: 175 LFTGDFIVDPHAA---LHKEQFTALVRDVKDSLRADGFLLSLTVLPNVNSTWYFDIPALN 231 +F A L + L+ L + + + + P L+ Sbjct: 215 VFIETLSARLRPAGRMLVMDGQPDLLSTETSKLVDHYIYQAYWESSTSSVIYKINKPNLD 274 Query: 232 GLVDF--VNLATFDFLTPARNPEEADYSAPIYHPDGSKDRLAHLNADFQVEYWLSQGFPS 289 D+ + T +F + Y++ + L + + ++ + + PS Sbjct: 275 ---DWERKTIITVEFEQGWKTGGITYYTS-------VRPELNSMEGNQILD-YATLDLPS 323 Query: 290 NKINLGVATYGNAWKLTKDSGLEGVPVVPETSGPAPEGFQS 330 K G+ TY + D + + G Sbjct: 324 GKRIGGIGTYHMEYDYPNDPPYKWLRKALYFGNQVYPGKFD 364 >1TZ7-A nrPDB Length = 505 Score = 31.7 bits (70), Expect = 0.60, Method: Composition-based stats. Identities = 16/73 (21%), Positives = 31/73 (42%), Gaps = 1/73 (1%) Query: 137 DLVKTYGFDGLDLAYQFPKNKPRKVHGDLGLA-WKSIKKLFTGDFIVDPHAALHKEQFTA 195 D ++ F G + ++ P + V+G A K++ K F +P A T Sbjct: 301 DFLRLDHFRGFEAYWEVPYGEETAVNGRWVKAPGKTLFKKLLSYFPKNPFIAEDLGFITD 360 Query: 196 LVRDVKDSLRADG 208 VR ++++ + G Sbjct: 361 EVRYLRETFKIPG 373 >2GSJ-A nrPDB Length = 271 Score = 31.7 bits (70), Expect = 0.66, Method: Composition-based stats. Identities = 20/105 (19%), Positives = 34/105 (32%), Gaps = 2/105 (1%) Query: 95 PHLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDLVKTYGFDGLDLAYQFP 154 +KV+LS+GG + + RS+ + DG+D + Sbjct: 70 RGIKVMLSIGGGAGSYSLSSVQDARSVADYIWNNFLGGRSSSRPLGDAVLDGVDFDIEHG 129 Query: 155 KNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHA--ALHKEQFTALV 197 + L + KK+F P +L+K T L Sbjct: 130 GAYYDALARRLSEHNRGGKKVFLSAAPQCPFPDQSLNKALSTGLF 174 >3MAN-A nrPDB Length = 302 Score = 31.0 bits (68), Expect = 1.0, Method: Composition-based stats. Identities = 26/188 (13%), Positives = 50/188 (26%), Gaps = 21/188 (11%) Query: 157 KPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTALVRDVKDSLRADGFLLSLTVL 216 K + + ++ G V +L K+ + +V D+ Sbjct: 42 KSHGANTVRVVLSNGVRWSKNGPSDVANVISLCKQNRLICMLEVHDT------------- 88 Query: 217 PNVNSTWYFDIPALNGLVDFVNLATFDFLTPARNPEEADYSAPIYHPDGSKDRLAHLNAD 276 L+ VD+ + P Y D + + Sbjct: 89 --TGYGEQSGASTLDQAVDYWIELKSVLQGEEDYVLINIGNEP-YGNDSATVAAWATDTS 145 Query: 277 FQVEYWLSQGFPSNKINLGVATYGNAWKLTKDSGLEGVPVVPETSGPAPE----GFQSQK 332 ++ + GF + + + +G W T + + V T G SQ Sbjct: 146 AAIQRLRAAGF-EHTLVVDAPNWGQDWTNTMRNNADQVYASDPTGNTVFSIHMYGVYSQA 204 Query: 333 PGLLSYAE 340 + SY E Sbjct: 205 STITSYLE 212 >4A1O-A nrPDB Length = 523 Score = 31.0 bits (68), Expect = 1.0, Method: Composition-based stats. Identities = 16/95 (16%), Positives = 27/95 (28%), Gaps = 7/95 (7%) Query: 276 DFQVEYWLSQGFPSNKINLGVA-TYGNAWKLTKDSGLEGVPVVPETSGPAPEGFQSQKPG 334 D V W+ Q +G +W+ P P + PG Sbjct: 189 DIAVASWMQQTLAPEHPVAAFPQWFGRSWRRVAMLRYGENPHQQAALYGDPTAW----PG 244 Query: 335 LLSYAEICGKLSNPQNQFLKGNESPLRRVSDPTKR 369 L ++ GK + N ++ R D + Sbjct: 245 LAQAEQLHGKDMSYNN--FTDADAAWRAAFDHEQT 277 >4NUY-A nrPDB Length = 899 Score = 30.6 bits (67), Expect = 1.3, Method: Composition-based stats. Identities = 22/105 (20%), Positives = 41/105 (39%), Gaps = 16/105 (15%) Query: 59 GYAGLRGENLQAYSMNENLDIYKHQFSEVTSLKRKYPHL-----KVLLSV------GGDH 107 L E A+ ++ Y + E+ + + P L +V+ ++ GGD+ Sbjct: 39 SMGELPKEVDLAFIFHDWTKDYSLFWKELAT--KHVPKLNKQGTRVIRTIPWRFLAGGDN 96 Query: 108 DIDPDHPNKYIDLLEGEKVRQIGFIRSAYDLVKTYGFDGLDLAYQ 152 + +KY + EG K + + V Y DGLD+ + Sbjct: 97 SGIAEDTSKYPNTPEGNKALAKAIVD---EYVYKYNLDGLDVDVE 138 >3V6B-R nrPDB Length = 424 Score = 30.2 bits (66), Expect = 2.1, Method: Composition-based stats. Identities = 12/58 (20%), Positives = 22/58 (37%), Gaps = 3/58 (5%) Query: 146 GLDLAYQFPKNK---PRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTALVRDV 200 G+D +++P +K + V+ DL S K F +D + +T Sbjct: 125 GIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSG 182 >3V2A-R nrPDB Length = 772 Score = 30.2 bits (66), Expect = 2.1, Method: Composition-based stats. Identities = 12/58 (20%), Positives = 22/58 (37%), Gaps = 3/58 (5%) Query: 146 GLDLAYQFPKNK---PRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTALVRDV 200 G+D +++P +K + V+ DL S K F +D + +T Sbjct: 255 GIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSG 312 >3S35-X nrPDB Length = 122 Score = 30.2 bits (66), Expect = 2.1, Method: Composition-based stats. Identities = 12/58 (20%), Positives = 22/58 (37%), Gaps = 3/58 (5%) Query: 146 GLDLAYQFPKNK---PRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTALVRDV 200 G+D +++P +K + V+ DL S K F +D + +T Sbjct: 39 GIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSG 96 >2X1X-R nrPDB Length = 213 Score = 30.2 bits (66), Expect = 2.1, Method: Composition-based stats. Identities = 12/58 (20%), Positives = 22/58 (37%), Gaps = 3/58 (5%) Query: 146 GLDLAYQFPKNK---PRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTALVRDV 200 G+D +++P +K + V+ DL S K F +D + +T Sbjct: 136 GIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSG 193 >1YTQ-A nrPDB Length = 204 Score = 29.8 bits (65), Expect = 2.3, Method: Composition-based stats. Identities = 16/95 (16%), Positives = 27/95 (28%), Gaps = 1/95 (1%) Query: 311 LEGVPVVPETSGPAPEGFQSQKPGLLSYAEICGKLSNPQNQFLKGNESPLRRVSDPTKRF 370 L G + +G G + G E Q F KG + + Sbjct: 33 LNGPCPNLKETGVEKAGSVLVQAGPWVGYE-QANCKGEQFVFEKGEYPRWDSWTSSRRTD 91 Query: 371 GGIAYRPVDGQITEGIWVSYDDPDSASNKAAYARV 405 + RP+ E + Y++P+ K Sbjct: 92 SLSSLRPIKVDSQEHKIILYENPNFTGKKMEIIDD 126 >3VLI-A nrPDB Length = 737 Score = 29.8 bits (65), Expect = 2.6, Method: Composition-based stats. Identities = 10/92 (10%), Positives = 25/92 (27%), Gaps = 6/92 (6%) Query: 300 GNAWKLTKDSGLEGVPVVPETSGPAPEGFQSQKPGLLSYAEICGKLSNPQNQFLKGNESP 359 G W+ + G + GP + G + L + + + KG Sbjct: 287 GLGWQNKNGNSKGGEMITSGIEGPWTQSPTEWDMGYI------NNLLDYEWEPEKGPGGA 340 Query: 360 LRRVSDPTKRFGGIAYRPVDGQITEGIWVSYD 391 + + + + + ++ D Sbjct: 341 WQWAPKSEELKNSVPDAHDPDEKQTPMMLTTD 372 >1LFW-A nrPDB Length = 470 Score = 29.8 bits (65), Expect = 2.7, Method: Composition-based stats. Identities = 12/61 (19%), Positives = 20/61 (32%), Gaps = 5/61 (8%) Query: 243 DFLTPARNPEEADYSAPIYHPDGSKDRLAHLNADFQVEYWLSQGFPSNKINLGVATYGNA 302 D + + + P Y P L Y G P +++ +G TYG Sbjct: 366 DKFSGILDVTYNGFEEPHYVPGSDPMVQTLLKV-----YEKQTGKPGHEVVIGGGTYGRL 420 Query: 303 W 303 + Sbjct: 421 F 421 >3U37-A nrPDB Length = 408 Score = 29.4 bits (64), Expect = 2.8, Method: Composition-based stats. Identities = 11/52 (21%), Positives = 24/52 (46%), Gaps = 10/52 (19%) Query: 63 LRGENLQAYSMNENLDIYKHQFSEV----------TSLKRKYPHLKVLLSVG 104 L ++ + Y M N D +++ E+ T L++ P+ +++ S G Sbjct: 288 LNPDDGKTYKMRTNTDGTRNREDELKIVSAIIDFLTMLRKHNPNAQIIWSYG 339 >3HA9-A nrPDB Length = 165 Score = 29.4 bits (64), Expect = 3.1, Method: Composition-based stats. Identities = 8/47 (17%), Positives = 18/47 (38%), Gaps = 1/47 (2%) Query: 237 VNLATFDFLTPARNPEEADYSAPIYHPDGSKDRLAHLNADFQVEYWL 283 +++ DF T + + P Y P + + A++ W+ Sbjct: 69 ISVIAIDFWTA-EALKALGLNKPGYPPPDTPEMFRKFIANYGDPSWI 114 >1F8Q-A nrPDB Length = 263 Score = 29.4 bits (64), Expect = 3.2, Method: Composition-based stats. Identities = 19/124 (15%), Positives = 40/124 (32%), Gaps = 10/124 (8%) Query: 181 IVDPHAALHKEQFTALVRDVKDSLRADGFLLSLTVLPNVNSTWYF---DIPALNGLVDFV 237 + K+ AL ++ + LL + D + VD Sbjct: 10 DPRSYGMFIKDLRNAL--PFREKVYNIPLLLPSVSGAGRYLLMHLFNRDGKTITVAVDVT 67 Query: 238 NL--ATF--DFLTPARNPEEADYSAPIYHPDGSKDRLAHLNADFQVEYWLSQGFPSNKIN 293 N+ + D + N A+ ++ D + + D++ ++ G P KI Sbjct: 68 NVYIMGYLADTTSYFFNEPAAELASQYVFRDARRKITLPYSGDYE-RLQIAAGKPREKIP 126 Query: 294 LGVA 297 +G+ Sbjct: 127 IGLP 130 >4E2O-A nrPDB Length = 454 Score = 29.0 bits (63), Expect = 4.1, Method: Composition-based stats. Identities = 10/76 (13%), Positives = 25/76 (32%), Gaps = 2/76 (2%) Query: 69 QAYSMNENLDIYKHQFSEVTSLKRKYPHLKV-LLSVGGDHDIDPDHPNKYIDLLEG-EKV 126 + + N+ + + L ++ P +K L+ + D +D + K Sbjct: 140 EIFDWNDQTQLENGWVYGLPDLAQENPEVKTYLIDAAKWWIKETDIDGYRLDTVRHVPKS 199 Query: 127 RQIGFIRSAYDLVKTY 142 F + + K + Sbjct: 200 FWQEFAKEVKSVKKDF 215 >2X1I-A nrPDB Length = 500 Score = 29.0 bits (63), Expect = 4.4, Method: Composition-based stats. Identities = 32/163 (19%), Positives = 50/163 (30%), Gaps = 13/163 (7%) Query: 138 LVKTYGFDGLDLAYQFPKNKPRKVHGDLGLA-WKSIKKLFTGDFIVDPHAALHKEQFTAL 196 LV+ F G + ++ P + P V G A + + F P A T Sbjct: 289 LVRIDHFRGFEAYWEIPASCPTAVEGRWVKAPGEKLFARIQEAFGRIPILAEDLGVITPE 348 Query: 197 VRDVKDSLRADGFLLSLTVLPNVNSTWYFD--IPALNGLVDFVNLATFDFLTPARNPEEA 254 V ++D G + N + P +V V T D T A Sbjct: 349 VEALRDRFGLPGMKVLQFAFDNGMENPFLPHNYPEHGRVV--VYTGTHDNDTTLGWYRTA 406 Query: 255 DYSAPIYHPDGSKDRLAHLNADFQVEYWLSQGFPSNKINLGVA 297 +D L AD+ + + P + LG+A Sbjct: 407 TPH--------ERDFLKRYLADWGITFREEAEVPWALMRLGMA 441 >4TOQ-A nrPDB Length = 273 Score = 29.0 bits (63), Expect = 4.5, Method: Composition-based stats. Identities = 11/57 (19%), Positives = 19/57 (33%) Query: 96 HLKVLLSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIRSAYDLVKTYGFDGLDLAYQ 152 +KVL+S+GG D +S+ + DG+D + Sbjct: 71 DIKVLMSIGGGAGDYSLVSEADADNFADYLWNNFLGGQSSSRPLGDAVLDGIDFDIE 127 >1OM0-A nrPDB Length = 274 Score = 29.0 bits (63), Expect = 4.5, Method: Composition-based stats. Identities = 27/176 (15%), Positives = 48/176 (27%), Gaps = 15/176 (8%) Query: 243 DFLTPARNPEEADYSAPIYHPDGSKDRLAHLNADFQVEYWLSQGFPSNKI-NLGVATYGN 301 D N + P G V+ +L G P+++ L + + Sbjct: 94 DLFDHLWNSYFGGSKPSVPRPFGDAWL-------DGVDLFLEHGTPADRYDVLALELAKH 146 Query: 302 AWKLTKDSGLEGVPVVPETSGPAPEGFQSQKPGLLSYAEICGKLSNPQNQFLKGNESPLR 361 + L V PA ++ G+ + S+ G E Sbjct: 147 NIRGGPGKPLHLTATVRCGYPPAAHVGRALATGIFERVHVRTYESDKWCNQNLGWEGSWD 206 Query: 362 RVSDPTKRFGGIAYRPVDGQITEGIWVSYDDPDSASNKAAYA--RVKNLGGVALFD 415 + + Y + WV P + A + N GG+ L+D Sbjct: 207 KWTA--AYPATRFYVGLTADDKSHQWV---HPKNVYYGVAPVAQKKDNYGGIMLWD 257 >6FOP-A nrPDB Length = 717 Score = 28.6 bits (62), Expect = 5.9, Method: Composition-based stats. Identities = 21/153 (13%), Positives = 40/153 (26%), Gaps = 25/153 (16%) Query: 244 FLTPARNPEEADYSAPIYHPDGSKDRLAHLNADF-------QVEYWLSQGFPSNKINL-- 294 + +N +S+ PD D+++ D ++ L +G P Sbjct: 81 YFGAHKNDFTVGHSSVYTFPDARADKISDFAVDAVMASGSGSIKATLMKGSPYAYFVFTG 140 Query: 295 --------GVA--TYGNAWKLTKDSGLEG------VPVVPETSGPAPEGFQSQKPGLLSY 338 G YG++ + G P + G P +Y Sbjct: 141 GNPRIDFSGTPTVFYGDSGSQCLGVTINGVNYGLFAPSGSKWQGIGTGTITCILPAGKNY 200 Query: 339 AEICGKLSNPQNQFLKGNESPLRRVSDPTKRFG 371 I N + + V+D + Sbjct: 201 FSIAVLPDNTVSTLTYYKDYAYCFVTDTKVEWS 233 >2D3L-A nrPDB Length = 485 Score = 28.3 bits (61), Expect = 7.1, Method: Composition-based stats. Identities = 15/99 (15%), Positives = 28/99 (28%), Gaps = 5/99 (5%) Query: 140 KTYGFDGLDLAYQFPKNKPRKVHGDLGLAWKSIKKLFTGDFIVDPHAALHKEQFTALVRD 199 + Y FDG+D R + + D + L + Sbjct: 158 RWYHFDGVDWD-----QSRRLNNRIYKFRGHGKAWDWEVDTENGNYDYLMYADIDMDHPE 212 Query: 200 VKDSLRADGFLLSLTVLPNVNSTWYFDIPALNGLVDFVN 238 V + LR G + T+ + + D++N Sbjct: 213 VVNELRNWGVWYTNTLGLDGFRIDAVKHIKYSFTRDWIN 251 >2VY0-A nrPDB Length = 264 Score = 27.9 bits (60), Expect = 9.9, Method: Composition-based stats. Identities = 9/33 (27%), Positives = 15/33 (45%) Query: 101 LSVGGDHDIDPDHPNKYIDLLEGEKVRQIGFIR 133 L+VGG +PD + + + VR F+ Sbjct: 231 LAVGGYWPGNPDATTPFPAKMVVDYVRVYSFVS 263 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.310 0.120 0.353 Lambda K H 0.267 0.0369 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 17,361,929 Number of Sequences: 36641 Number of extensions: 715547 Number of successful extensions: 2430 Number of sequences better than 10.0: 95 Number of HSP's better than 10.0 without gapping: 107 Number of HSP's successfully gapped in prelim test: 46 Number of HSP's that attempted gapping in prelim test: 1842 Number of HSP's gapped (non-prelim): 213 length of query: 440 length of database: 10,336,785 effective HSP length: 100 effective length of query: 340 effective length of database: 6,672,685 effective search space: 2268712900 effective search space used: 2268712900 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.4 bits) S2: 60 (27.9 bits)