BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q9UHD2 (729 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 6NT9-A nrPDB 1518 0.0 6O8B-A nrPDB 1361 0.0 4JLC-A nrPDB 1316 0.0 4EUT-A nrPDB 805 0.0 4EUU-A nrPDB 647 0.0 4KIK-B nrPDB 137 1e-32 5TQX-A nrPDB 130 2e-30 3QA8-A nrPDB 120 2e-27 4WNO-A nrPDB 115 8e-26 6QAU-A nrPDB 112 4e-25 2JAM-A nrPDB 110 2e-24 5XZW-A nrPDB 107 1e-23 5ES1-A nrPDB 103 2e-22 2HAK-A nrPDB 103 4e-22 6C9D-A nrPDB 103 4e-22 4PDS-A nrPDB 102 5e-22 2QNJ-A nrPDB 100 2e-21 5FG8-A nrPDB 99 6e-21 3IS5-A nrPDB 98 1e-20 5KZ7-A nrPDB 97 3e-20 4MVF-A nrPDB 97 3e-20 2Z7Q-A nrPDB 97 4e-20 3KK8-A nrPDB 96 5e-20 2BDW-A nrPDB 96 6e-20 3ZDU-A nrPDB 95 9e-20 4RGJ-A nrPDB 95 9e-20 3LIJ-A nrPDB 95 1e-19 3NCG-A nrPDB 95 1e-19 6CMJ-A nrPDB 94 1e-19 3DFA-A nrPDB 94 2e-19 6FDY-U nrPDB 94 2e-19 2J90-A nrPDB 94 3e-19 2VN9-A nrPDB 93 4e-19 2YAB-A nrPDB 92 6e-19 2Y7J-A nrPDB 92 6e-19 2A27-A nrPDB 92 7e-19 1ZWS-A nrPDB 92 9e-19 3HZT-A nrPDB 92 1e-18 2UV2-A nrPDB 92 1e-18 1PHK-A nrPDB 92 1e-18 6CCF-A nrPDB 92 1e-18 6HXF-B nrPDB 91 1e-18 3DXN-A nrPDB 91 2e-18 5VO2-A nrPDB 91 2e-18 2JC6-A nrPDB 91 3e-18 5D9K-A nrPDB 90 3e-18 4REW-A nrPDB 90 3e-18 4RED-A nrPDB 90 3e-18 4UZD-A nrPDB 90 4e-18 4CFH-A nrPDB 90 4e-18 3D2K-A nrPDB 90 4e-18 3F3Z-A nrPDB 89 8e-18 4B6L-A nrPDB 89 8e-18 1KOB-A nrPDB 89 8e-18 5YV8-A nrPDB 89 9e-18 5IG1-A nrPDB 88 1e-17 4D2V-A nrPDB 88 1e-17 2YCR-A nrPDB 88 1e-17 2W4O-A nrPDB 88 2e-17 2VZ6-A nrPDB 88 2e-17 5U6Y-A nrPDB 87 2e-17 4CQG-A nrPDB 87 3e-17 3GUB-A nrPDB 87 3e-17 3DAK-A nrPDB 87 3e-17 3KN6-A nrPDB 86 4e-17 4AGU-A nrPDB 86 6e-17 3I6U-A nrPDB 86 7e-17 5EZV-A nrPDB 85 1e-16 2X4F-A nrPDB 85 1e-16 5D7A-A nrPDB 85 1e-16 3Q5I-A nrPDB 85 1e-16 4U41-A nrPDB 85 1e-16 4CFF-A nrPDB 85 1e-16 2V7O-A nrPDB 84 2e-16 2BRG-A nrPDB 84 2e-16 4D28-A nrPDB 84 2e-16 5DBX-A nrPDB 84 2e-16 3COM-A nrPDB 84 2e-16 2YZA-A nrPDB 84 3e-16 4RLP-A nrPDB 84 3e-16 3SOA-A nrPDB 84 3e-16 3BHH-A nrPDB 84 3e-16 4CZT-A nrPDB 83 4e-16 3MA6-A nrPDB 83 4e-16 4L42-A nrPDB 83 5e-16 4FG9-A nrPDB 82 6e-16 5JN2-A nrPDB 82 9e-16 4WB7-A nrPDB 82 1e-15 5JZN-A nrPDB 82 1e-15 6E9W-A nrPDB 81 1e-15 2XNP-A nrPDB 81 1e-15 6ED6-A nrPDB 81 2e-15 4JXF-A nrPDB 81 2e-15 3TKU-A nrPDB 80 3e-15 4LG4-A nrPDB 80 3e-15 4BGQ-A nrPDB 80 3e-15 6AO5-A nrPDB 80 4e-15 3HDN-A nrPDB 79 6e-15 3TXO-A nrPDB 79 6e-15 2WTK-C nrPDB 79 6e-15 5N23-A nrPDB 79 8e-15 6FD3-A nrPDB 79 9e-15 1VZO-A nrPDB 79 9e-15 5FET-A nrPDB 79 9e-15 4QMW-A nrPDB 79 1e-14 1KOA-A nrPDB 78 1e-14 4YFF-A nrPDB 78 1e-14 3UTO-A nrPDB 78 1e-14 4BBM-A nrPDB 78 1e-14 6E2O-A nrPDB 78 2e-14 5X3F-B nrPDB 78 2e-14 5DYK-A nrPDB 77 2e-14 2VD5-A nrPDB 77 2e-14 3Q53-A nrPDB 77 3e-14 3NIZ-A nrPDB 77 3e-14 4B8L-A nrPDB 77 4e-14 4AF3-A nrPDB 77 4e-14 3TAC-A nrPDB 76 5e-14 4J52-A nrPDB 76 5e-14 6CQF-A nrPDB 76 6e-14 3UC3-A nrPDB 76 6e-14 2OU7-A nrPDB 76 6e-14 2JDO-A nrPDB 76 7e-14 3H4J-B nrPDB 75 7e-14 3MIA-A nrPDB 75 1e-13 2XIK-A nrPDB 75 1e-13 4AW2-A nrPDB 75 1e-13 5J5T-A nrPDB 75 1e-13 4Y83-A nrPDB 74 2e-13 4I6B-A nrPDB 74 2e-13 2HW6-A nrPDB 74 2e-13 5YKS-A nrPDB 74 2e-13 5G6V-A nrPDB 74 2e-13 5F9E-A nrPDB 74 2e-13 3ORP-A nrPDB 74 2e-13 4JG6-A nrPDB 74 2e-13 4GS6-A nrPDB 74 3e-13 3ALO-A nrPDB 73 4e-13 5AIR-A nrPDB 73 4e-13 4YNZ-A nrPDB 73 4e-13 1NY3-A nrPDB 73 4e-13 4NIF-A nrPDB 73 4e-13 2OZA-A nrPDB 73 4e-13 3HKO-A nrPDB 73 5e-13 4C0T-A nrPDB 73 5e-13 1U59-A nrPDB 72 7e-13 3KA0-A nrPDB 72 8e-13 5O0Y-A nrPDB 72 8e-13 3C51-A nrPDB 72 9e-13 5KKR-C nrPDB 72 9e-13 1FOT-A nrPDB 72 1e-12 4UY9-A nrPDB 72 1e-12 3LM0-A nrPDB 72 1e-12 3EQC-A nrPDB 72 1e-12 4KS7-A nrPDB 72 1e-12 5VD3-A nrPDB 71 1e-12 2GCD-A nrPDB 71 1e-12 3UDB-A nrPDB 71 2e-12 3ORZ-A nrPDB 71 2e-12 1U5R-A nrPDB 71 2e-12 3FXW-A nrPDB 71 2e-12 5H2U-A nrPDB 70 2e-12 6BDL-A nrPDB 70 3e-12 4AN9-A nrPDB 70 3e-12 4FR4-A nrPDB 70 3e-12 2A1A-B nrPDB 70 3e-12 5KCV-A nrPDB 70 3e-12 3DB8-A nrPDB 70 3e-12 5X5O-A nrPDB 70 3e-12 5B2L-A nrPDB 70 4e-12 2W96-B nrPDB 70 4e-12 5WAX-A nrPDB 70 4e-12 3MV5-A nrPDB 70 5e-12 2WQN-A nrPDB 69 5e-12 2OZO-A nrPDB 69 5e-12 3DTC-A nrPDB 69 6e-12 4FZF-B nrPDB 69 6e-12 3QGY-A nrPDB 69 6e-12 5HI2-A nrPDB 69 7e-12 4YZB-A nrPDB 69 7e-12 3ZUT-A nrPDB 69 7e-12 1G3N-A nrPDB 69 8e-12 6DBM-A nrPDB 69 9e-12 1CM8-A nrPDB 69 9e-12 3A8W-A nrPDB 69 1e-11 4F0G-A nrPDB 68 1e-11 3SXS-A nrPDB 68 1e-11 3DLS-A nrPDB 68 1e-11 4EQM-A nrPDB 68 1e-11 4E20-A nrPDB 68 2e-11 4KRC-A nrPDB 68 2e-11 6BXI-A nrPDB 67 2e-11 1S9I-A nrPDB 67 2e-11 3E3P-A nrPDB 67 2e-11 2F57-A nrPDB 67 3e-11 4APC-A nrPDB 67 3e-11 6HV0-A nrPDB 67 4e-11 6DBN-A nrPDB 67 4e-11 3OMV-A nrPDB 67 4e-11 3BBT-B nrPDB 67 4e-11 6GU6-A nrPDB 66 5e-11 4OLI-A nrPDB 66 5e-11 4RA4-A nrPDB 66 5e-11 1UA2-A nrPDB 66 5e-11 3UIU-A nrPDB 66 5e-11 4PWN-A nrPDB 66 6e-11 3AOX-A nrPDB 66 6e-11 5HIE-A nrPDB 65 8e-11 4QNY-A nrPDB 65 8e-11 3PLS-A nrPDB 65 9e-11 3PPZ-A nrPDB 65 9e-11 4MYG-A nrPDB 65 1e-10 1TKI-A nrPDB 65 1e-10 5L6P-A nrPDB 65 1e-10 2W1I-A nrPDB 65 1e-10 3IO7-A nrPDB 65 1e-10 3KUL-B nrPDB 65 1e-10 5MJB-A nrPDB 65 1e-10 5LOH-A nrPDB 65 1e-10 4AU8-A nrPDB 64 2e-10 6F3F-A nrPDB 64 2e-10 4E93-A nrPDB 64 2e-10 2H8H-A nrPDB 64 2e-10 2I0E-A nrPDB 64 2e-10 2Q0N-A nrPDB 64 2e-10 4XBR-A nrPDB 64 2e-10 3PFQ-A nrPDB 64 3e-10 2BPM-A nrPDB 64 3e-10 4FIE-A nrPDB 64 3e-10 4TNB-A nrPDB 63 4e-10 3MN3-A nrPDB 63 4e-10 4CRS-A nrPDB 63 4e-10 4JDH-A nrPDB 63 4e-10 4PL5-B nrPDB 63 5e-10 1ZXE-A nrPDB 62 6e-10 6CKI-A nrPDB 62 6e-10 5SYS-A nrPDB 62 6e-10 3GC9-A nrPDB 62 7e-10 3M42-A nrPDB 62 7e-10 4UYA-A nrPDB 62 7e-10 2R2P-A nrPDB 62 7e-10 1V0B-A nrPDB 62 8e-10 2F9G-A nrPDB 62 8e-10 4CSV-A nrPDB 62 9e-10 6GVJ-A nrPDB 62 9e-10 3DKO-A nrPDB 62 1e-09 4IAN-A nrPDB 62 1e-09 3E7O-A nrPDB 61 1e-09 4H1J-A nrPDB 61 1e-09 5O2C-A nrPDB 61 2e-09 3EB0-A nrPDB 61 2e-09 5EFQ-A nrPDB 61 2e-09 5O2B-A nrPDB 61 2e-09 3HMP-A nrPDB 61 2e-09 4X7Q-B nrPDB 60 2e-09 3OHT-A nrPDB 60 2e-09 6CTH-A nrPDB 60 3e-09 4Y93-A nrPDB 60 3e-09 5AMN-A nrPDB 60 3e-09 4EBW-A nrPDB 60 3e-09 4P5Q-A nrPDB 60 4e-09 2VWV-A nrPDB 60 4e-09 2PL0-A nrPDB 60 4e-09 5AP3-A nrPDB 60 4e-09 6E4F-A nrPDB 59 6e-09 4XI2-A nrPDB 59 6e-09 4ZSG-A nrPDB 59 6e-09 1JPA-A nrPDB 59 7e-09 4IC8-A nrPDB 59 7e-09 3NYO-A nrPDB 59 7e-09 3N9X-A nrPDB 59 7e-09 4PDO-A nrPDB 59 8e-09 2J0K-A nrPDB 59 8e-09 3PVW-A nrPDB 59 8e-09 2ZMD-A nrPDB 59 8e-09 6DTL-A nrPDB 59 1e-08 2Y6O-A nrPDB 58 1e-08 3OZ6-A nrPDB 58 1e-08 5UUU-A nrPDB 58 2e-08 5C26-A nrPDB 58 2e-08 4NST-A nrPDB 58 2e-08 5Z33-A nrPDB 58 2e-08 2I6L-A nrPDB 58 2e-08 4OTD-A nrPDB 58 2e-08 4HVI-A nrPDB 57 2e-08 4OW8-A nrPDB 57 2e-08 4EWQ-A nrPDB 57 2e-08 4FL3-A nrPDB 57 2e-08 4X3F-A nrPDB 57 2e-08 1FVR-A nrPDB 57 2e-08 6B2Q-A nrPDB 57 2e-08 5UIU-A nrPDB 57 3e-08 5GNK-A nrPDB 57 3e-08 4G3E-A nrPDB 57 3e-08 5AWM-A nrPDB 57 3e-08 4YHJ-A nrPDB 57 3e-08 5TOS-A nrPDB 57 3e-08 2BUJ-A nrPDB 57 3e-08 2XS0-A nrPDB 57 3e-08 4E7W-A nrPDB 57 3e-08 2PMN-X nrPDB 56 5e-08 3RP9-A nrPDB 56 6e-08 5LPV-A nrPDB 56 6e-08 2DQ7-X nrPDB 56 7e-08 5LPZ-A nrPDB 55 9e-08 3I81-A nrPDB 55 9e-08 5IKW-A nrPDB 55 1e-07 5U6C-A nrPDB 55 1e-07 3FI2-A nrPDB 55 1e-07 3LMG-A nrPDB 55 1e-07 5ZTN-A nrPDB 55 1e-07 4M7I-A nrPDB 55 1e-07 1K9A-A nrPDB 55 1e-07 1JNK-A nrPDB 55 1e-07 3LZB-A nrPDB 55 2e-07 1BYG-A nrPDB 55 2e-07 3LLT-A nrPDB 55 2e-07 1LUF-A nrPDB 55 2e-07 2HK5-A nrPDB 54 2e-07 4IDT-A nrPDB 54 2e-07 3FME-A nrPDB 54 2e-07 2RIO-A nrPDB 54 2e-07 3QUP-A nrPDB 54 3e-07 6NPU-A nrPDB 53 4e-07 3GC0-A nrPDB 53 5e-07 4AT3-A nrPDB 53 5e-07 2OGV-A nrPDB 53 5e-07 5FM2-A nrPDB 53 6e-07 4XEY-B nrPDB 52 6e-07 5X8I-B nrPDB 52 7e-07 3VN9-A nrPDB 52 7e-07 5USZ-A nrPDB 52 7e-07 3A4O-X nrPDB 52 8e-07 5HVK-A nrPDB 52 8e-07 3NIE-A nrPDB 52 9e-07 2XYN-A nrPDB 52 1e-06 5TE0-A nrPDB 52 1e-06 3PP0-A nrPDB 52 1e-06 3G2F-A nrPDB 51 1e-06 3BEA-A nrPDB 51 2e-06 5HLW-A nrPDB 51 2e-06 5NGU-A nrPDB 51 2e-06 3G0E-A nrPDB 50 3e-06 4MWI-A nrPDB 50 3e-06 4CRL-A nrPDB 50 3e-06 4LRM-A nrPDB 50 3e-06 4QTB-A nrPDB 50 3e-06 2FO0-A nrPDB 50 3e-06 6GQK-A nrPDB 50 4e-06 4M66-A nrPDB 50 4e-06 3V5Q-A nrPDB 50 4e-06 5U6B-A nrPDB 50 5e-06 4XLV-A nrPDB 49 5e-06 2PZI-A nrPDB 49 6e-06 3C1X-A nrPDB 49 6e-06 3CJF-A nrPDB 49 8e-06 4O2Z-A nrPDB 49 9e-06 4HZS-A nrPDB 49 9e-06 1U54-B nrPDB 49 1e-05 3PG1-A nrPDB 49 1e-05 5L2Q-C nrPDB 48 1e-05 4R7H-A nrPDB 48 1e-05 5WNO-A nrPDB 48 1e-05 5GRN-A nrPDB 48 1e-05 4Y12-A nrPDB 48 1e-05 3KRL-A nrPDB 48 2e-05 5KMM-A nrPDB 48 2e-05 4NEU-A nrPDB 48 2e-05 4XUF-A nrPDB 48 2e-05 4BTF-A nrPDB 48 2e-05 5X02-A nrPDB 48 2e-05 5TUR-A nrPDB 47 2e-05 3BGP-A nrPDB 47 2e-05 4M69-B nrPDB 47 2e-05 4RC3-A nrPDB 47 2e-05 2JD5-A nrPDB 47 3e-05 5UNP-A nrPDB 47 3e-05 1AD5-A nrPDB 47 4e-05 5XD6-A nrPDB 47 4e-05 5J0A-A nrPDB 46 5e-05 6FYV-A nrPDB 46 7e-05 5Y86-A nrPDB 46 7e-05 6O6Q-A nrPDB 45 9e-05 5CLR-A nrPDB 45 9e-05 2Y4I-B nrPDB 45 1e-04 3RAW-A nrPDB 45 1e-04 3REP-A nrPDB 44 2e-04 5X18-A nrPDB 44 3e-04 5XVU-A nrPDB 44 3e-04 4IX6-A nrPDB 43 4e-04 4LFI-A nrPDB 43 5e-04 4TPT-A nrPDB 42 7e-04 6FER-A nrPDB 42 7e-04 4BTK-A nrPDB 42 8e-04 5VC6-A nrPDB 42 9e-04 4NFN-A nrPDB 42 9e-04 4XCU-A nrPDB 42 9e-04 3UIM-A nrPDB 42 0.001 5OAT-A nrPDB 42 0.001 4LQP-A nrPDB 42 0.001 2CHL-A nrPDB 42 0.001 2CMW-A nrPDB 42 0.001 5M07-A nrPDB 42 0.001 6HMD-A nrPDB 42 0.001 3ZZW-A nrPDB 42 0.001 4F9B-A nrPDB 41 0.002 5VDK-A nrPDB 41 0.002 4K33-A nrPDB 41 0.002 2PSQ-A nrPDB 41 0.002 2PVN-A nrPDB 41 0.002 2C47-A nrPDB 41 0.002 3QD2-B nrPDB 40 0.002 3SV0-A nrPDB 40 0.004 4RT7-A nrPDB 40 0.004 2WTK-B nrPDB 40 0.005 5EG3-A nrPDB 40 0.005 3VHK-A nrPDB 40 0.005 3TT0-A nrPDB 39 0.005 3GQL-A nrPDB 39 0.006 6EII-A nrPDB 39 0.006 3SOC-A nrPDB 39 0.006 2QKW-B nrPDB 39 0.007 4TN6-A nrPDB 39 0.007 5A46-A nrPDB 39 0.007 4C59-A nrPDB 39 0.008 4XHH-A nrPDB 39 0.008 6FEX-A nrPDB 39 0.008 2WO6-A nrPDB 39 0.009 3HNG-A nrPDB 39 0.010 4MD7-E nrPDB 38 0.013 4XHL-A nrPDB 37 0.027 3ZBF-A nrPDB 37 0.034 4JRN-A nrPDB 37 0.039 2H34-A nrPDB 37 0.042 4CI6-B nrPDB 35 0.085 6BSD-A nrPDB 35 0.098 5E8V-A nrPDB 35 0.10 5FQD-C nrPDB 35 0.10 6EAS-A nrPDB 33 0.31 2X7G-A nrPDB 33 0.45 4NT4-A nrPDB 33 0.51 6J6I-B nrPDB 32 0.74 5VE6-A nrPDB 32 0.74 6EWX-A nrPDB 32 0.79 1MPY-A nrPDB 32 1.0 1CSN-A nrPDB 32 1.1 6DC0-A nrPDB 32 1.2 5CEK-A nrPDB 31 1.5 4WUA-A nrPDB 31 1.7 5LVV-A nrPDB 31 2.2 6EQI-C nrPDB 30 2.7 6J2C-O nrPDB 30 2.8 1W3B-A nrPDB 30 4.7 3OP7-A nrPDB 29 7.9 4QX0-A nrPDB 29 8.5 >6NT9-A nrPDB Length = 742 Score = 1518 bits (3931), Expect = 0.0, Method: Compositional matrix adjust. Identities = 728/729 (99%), Positives = 729/729 (100%) Query: 1 MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLK 60 MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLK Sbjct: 1 MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLK 60 Query: 61 KLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVV 120 KLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVV Sbjct: 61 KLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVV 120 Query: 121 GGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYL 180 GGMNHLRENGIVHR+IKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYL Sbjct: 121 GGMNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYL 180 Query: 181 HPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITG 240 HPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITG Sbjct: 181 HPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITG 240 Query: 241 KPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFA 300 KPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFA Sbjct: 241 KPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFA 300 Query: 301 ETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLV 360 ETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLV Sbjct: 301 ETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLV 360 Query: 361 LEPGRLAQHFPKTTEENPIFVVSREPLNTIGLIYEKISLPKVHPRYDLDGDASMAKAITG 420 LEPGRLAQHFPKTTEENPIFVVSREPLNTIGLIYEKISLPKVHPRYDLDGDASMAKAITG Sbjct: 361 LEPGRLAQHFPKTTEENPIFVVSREPLNTIGLIYEKISLPKVHPRYDLDGDASMAKAITG 420 Query: 421 VVCYACRIASTLLLYQELMRKGIRWLIELIKDDYNETVHKKTEVVITLDFCIRNIEKTVK 480 VVCYACRIASTLLLYQELMRKGIRWLIELIKDDYNETVHKKTEVVITLDFCIRNIEKTVK Sbjct: 421 VVCYACRIASTLLLYQELMRKGIRWLIELIKDDYNETVHKKTEVVITLDFCIRNIEKTVK 480 Query: 481 VYEKLMKINLEAAELGEISDIHTKLLRLSSSQGTIETSLQDIDSRLSPGGSLADAWAHQE 540 VYEKLMKINLEAAELGEISDIHTKLLRLSSSQGTIETSLQDIDSRLSPGGSLADAWAHQE Sbjct: 481 VYEKLMKINLEAAELGEISDIHTKLLRLSSSQGTIETSLQDIDSRLSPGGSLADAWAHQE 540 Query: 541 GTHPKDRNVEKLQVLLNCMTEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAMTH 600 GTHPKDRNVEKLQVLLNCMTEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAMTH Sbjct: 541 GTHPKDRNVEKLQVLLNCMTEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAMTH 600 Query: 601 FTDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQCFDIEEEVSKYQEYTNELQETLPQ 660 FTDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQCFDIEEEVSKYQEYTNELQETLPQ Sbjct: 601 FTDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQCFDIEEEVSKYQEYTNELQETLPQ 660 Query: 661 KMFTASSGIKHTMTPIYPSSNTLVEMTLGMKKLKEEMEGVVKELAENNHILERFGSLTMD 720 KMFTASSGIKHTMTPIYPSSNTLVEMTLGMKKLKEEMEGVVKELAENNHILERFGSLTMD Sbjct: 661 KMFTASSGIKHTMTPIYPSSNTLVEMTLGMKKLKEEMEGVVKELAENNHILERFGSLTMD 720 Query: 721 GGLRNVDCL 729 GGLRNVDCL Sbjct: 721 GGLRNVDCL 729 >6O8B-A nrPDB Length = 665 Score = 1361 bits (3523), Expect = 0.0, Method: Compositional matrix adjust. Identities = 652/656 (99%), Positives = 655/656 (99%) Query: 2 QSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKK 61 QSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKK Sbjct: 10 QSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKK 69 Query: 62 LNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVG 121 LNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVG Sbjct: 70 LNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVG 129 Query: 122 GMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLH 181 GMNHLRENGIVHR+IKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFV LYGTEEYLH Sbjct: 130 GMNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVELYGTEEYLH 189 Query: 182 PDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 241 PDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK Sbjct: 190 PDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 249 Query: 242 PSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFAE 301 PSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFAE Sbjct: 250 PSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFAE 309 Query: 302 TSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLVL 361 TSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLVL Sbjct: 310 TSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLVL 369 Query: 362 EPGRLAQHFPKTTEENPIFVVSREPLNTIGLIYEKISLPKVHPRYDLDGDASMAKAITGV 421 EPGRLAQHFPKTTEENPIFVVSREPL+TIGLIYEKISLPKVHPRYDLDGDASMAKAITGV Sbjct: 370 EPGRLAQHFPKTTEENPIFVVSREPLDTIGLIYEKISLPKVHPRYDLDGDASMAKAITGV 429 Query: 422 VCYACRIASTLLLYQELMRKGIRWLIELIKDDYNETVHKKTEVVITLDFCIRNIEKTVKV 481 VCYACRIASTLLLYQELMRKGIRWLIELIKDDYNETVHKKTEVVITLDFCIRNIEKTVKV Sbjct: 430 VCYACRIASTLLLYQELMRKGIRWLIELIKDDYNETVHKKTEVVITLDFCIRNIEKTVKV 489 Query: 482 YEKLMKINLEAAELGEISDIHTKLLRLSSSQGTIETSLQDIDSRLSPGGSLADAWAHQEG 541 YEKLMKINLEAAELGEISDIHTKLLRLSSSQGTIETSLQDIDSRLSPGGSLADAWAHQEG Sbjct: 490 YEKLMKINLEAAELGEISDIHTKLLRLSSSQGTIETSLQDIDSRLSPGGSLADAWAHQEG 549 Query: 542 THPKDRNVEKLQVLLNCMTEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAMTHF 601 THPKDRNVEKLQVLLNCMTEIYYQFKKD+AERRLAYNEEQIHKFDKQKLYYHATKAMTHF Sbjct: 550 THPKDRNVEKLQVLLNCMTEIYYQFKKDQAERRLAYNEEQIHKFDKQKLYYHATKAMTHF 609 Query: 602 TDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQCFDIEEEVSKYQEYTNELQET 657 TDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQCFDIEEEVSKYQEYTNELQET Sbjct: 610 TDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQCFDIEEEVSKYQEYTNELQET 665 >4JLC-A nrPDB Length = 657 Score = 1316 bits (3406), Expect = 0.0, Method: Compositional matrix adjust. Identities = 618/655 (94%), Positives = 643/655 (98%) Query: 2 QSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKK 61 QSTSNHLWLLSDILGQGATANVFRGRHKKTGDL+A+KVFNNISFLRPVDVQMREFEVLKK Sbjct: 3 QSTSNHLWLLSDILGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQMREFEVLKK 62 Query: 62 LNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVG 121 LNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVG Sbjct: 63 LNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVG 122 Query: 122 GMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLH 181 GMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLH Sbjct: 123 GMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLH 182 Query: 182 PDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 241 PDMYERAVLRKDHQKKYGATVDLWS+GVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK Sbjct: 183 PDMYERAVLRKDHQKKYGATVDLWSVGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 242 Query: 242 PSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFAE 301 PSGAISGVQKAENGPIDWSGDMP+SCSLS+GLQ LLTPVLANILEADQEKCWGFDQFFAE Sbjct: 243 PSGAISGVQKAENGPIDWSGDMPLSCSLSQGLQALLTPVLANILEADQEKCWGFDQFFAE 302 Query: 302 TSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLVL 361 TSD+LHRMVIHVFSLQ MTAHKIYIHSYNTA +FHELVYKQTKI+SSNQELIYEGRRLVL Sbjct: 303 TSDVLHRMVIHVFSLQHMTAHKIYIHSYNTAAVFHELVYKQTKIVSSNQELIYEGRRLVL 362 Query: 362 EPGRLAQHFPKTTEENPIFVVSREPLNTIGLIYEKISLPKVHPRYDLDGDASMAKAITGV 421 E GRLAQHFPKTTEENPIFV SRE LNT+GL YEKISLPK+HPRYDLDGDASMAKA+TGV Sbjct: 363 ELGRLAQHFPKTTEENPIFVTSREQLNTVGLRYEKISLPKIHPRYDLDGDASMAKAVTGV 422 Query: 422 VCYACRIASTLLLYQELMRKGIRWLIELIKDDYNETVHKKTEVVITLDFCIRNIEKTVKV 481 VCYACR ASTLLLYQELMRKG+RWL+EL+KDDYNETVHKKTEVVITLDFCIRNIEKTVKV Sbjct: 423 VCYACRTASTLLLYQELMRKGVRWLVELVKDDYNETVHKKTEVVITLDFCIRNIEKTVKV 482 Query: 482 YEKLMKINLEAAELGEISDIHTKLLRLSSSQGTIETSLQDIDSRLSPGGSLADAWAHQEG 541 YEKLMK+NLEAAELGEISDIHTKLLRLSSSQGTIE+SLQDI SRLSPGG LAD WAHQEG Sbjct: 483 YEKLMKVNLEAAELGEISDIHTKLLRLSSSQGTIESSLQDISSRLSPGGLLADTWAHQEG 542 Query: 542 THPKDRNVEKLQVLLNCMTEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAMTHF 601 THP+DRNVEKLQVLLNC+TEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAM+HF Sbjct: 543 THPRDRNVEKLQVLLNCITEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAMSHF 602 Query: 602 TDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQCFDIEEEVSKYQEYTNELQE 656 ++ECV+KYEAF +KSEEW+RKMLHLRKQLLSLTNQCFDIEEEVSKYQ+YTNELQE Sbjct: 603 SEECVRKYEAFKDKSEEWMRKMLHLRKQLLSLTNQCFDIEEEVSKYQDYTNELQE 657 >4EUT-A nrPDB Length = 396 Score = 805 bits (2078), Expect = 0.0, Method: Compositional matrix adjust. Identities = 383/384 (99%), Positives = 384/384 (100%) Query: 2 QSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKK 61 QSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKK Sbjct: 4 QSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKK 63 Query: 62 LNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVG 121 LNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVG Sbjct: 64 LNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVG 123 Query: 122 GMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLH 181 GMNHLRENGIVHR+IKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLH Sbjct: 124 GMNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLH 183 Query: 182 PDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 241 PDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK Sbjct: 184 PDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 243 Query: 242 PSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFAE 301 PSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFAE Sbjct: 244 PSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFAE 303 Query: 302 TSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLVL 361 TSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLVL Sbjct: 304 TSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLVL 363 Query: 362 EPGRLAQHFPKTTEENPIFVVSRE 385 EPGRLAQHFPKTTEENPIFVVSRE Sbjct: 364 EPGRLAQHFPKTTEENPIFVVSRE 387 >4EUU-A nrPDB Length = 319 Score = 647 bits (1668), Expect = 0.0, Method: Compositional matrix adjust. Identities = 307/311 (98%), Positives = 308/311 (99%) Query: 2 QSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKK 61 QSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKK Sbjct: 4 QSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKK 63 Query: 62 LNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVG 121 LNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVG Sbjct: 64 LNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVG 123 Query: 122 GMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLH 181 GMNHLRENGIVHR+IKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLH Sbjct: 124 GMNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLH 183 Query: 182 PDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 241 PDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK Sbjct: 184 PDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 243 Query: 242 PSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFAE 301 PSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFAE Sbjct: 244 PSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFAE 303 Query: 302 TSDILHRMVIH 312 TSDILHR H Sbjct: 304 TSDILHRGNSH 314 >4KIK-B nrPDB Length = 677 Score = 137 bits (346), Expect = 1e-32, Method: Compositional matrix adjust. Identities = 104/368 (28%), Positives = 165/368 (44%), Gaps = 24/368 (6%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIV 68 W + + LG G NV R +++TG+ AIK R + E +++++L H N+V Sbjct: 21 WEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQIMRRLTHPNVV 80 Query: 69 KLFAIEEE----TTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 124 + E +L ME+C G L L + N GL E L +L D+ + Sbjct: 81 AARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALR 140 Query: 125 HLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDM 184 +L EN I+HRD+KP NI+ GE + ++K+ D G A+EL+ S GT +YL P++ Sbjct: 141 YLHENRIIHRDLKPENIVLQQGEQ-RLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPEL 199 Query: 185 YERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSG 244 E Q+KY TVD WS G + TG PF P P V + + S Sbjct: 200 LE--------QQKYTVTVDYWSFGTLAFECITGFRPFLPNWQP-----VQWHSKVRQKSE 246 Query: 245 AISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANIL-----EADQEKCWGFDQFF 299 V + NG + +S +P +L+ L L L +L + + +G + F Sbjct: 247 VDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCF 306 Query: 300 AETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRL 359 DIL+ ++H+ ++ T H + + + + T I +QEL+ E L Sbjct: 307 KALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQEA-GL 365 Query: 360 VLEPGRLA 367 L P + A Sbjct: 366 ALIPDKPA 373 >5TQX-A nrPDB Length = 655 Score = 130 bits (327), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 106/365 (29%), Positives = 171/365 (46%), Gaps = 40/365 (10%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIV 68 W + + LG G NV +H++ AIK + + E +++KKLNH N+V Sbjct: 10 WEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCHEIQIMKKLNHANVV 69 Query: 69 KLFAIEEETTTR-HKV--LIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 125 K + EE H V L ME+C G L +L +P N GL ES+ L +L D+ G+ + Sbjct: 70 KACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSGIRY 129 Query: 126 LRENGIVHRDIKPGNI-MRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDM 184 L EN I+HRD+KP NI ++ +G G+ ++K+ D G A++++ E GT +YL P++ Sbjct: 130 LHENKIIHRDLKPENIVLQDVG--GKIIHKIIDLGYAKDVDQGELCTEFVGTLQYLAPEL 187 Query: 185 YERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF----RPFEGPRRNKEVMYKIITG 240 +E K Y ATVD WS G + G PF +PF ++ I Sbjct: 188 FE--------NKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPF--------TWHEKIKK 231 Query: 241 KPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWG------ 294 K I ++ +G + +S +P SL + + L +L D ++ G Sbjct: 232 KDPKCIFACEEM-SGEVRFSSHLPQPNSLCSLIVEPMENWLQLMLNWDPQQRGGPVDLTL 290 Query: 295 -FDQFFAETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHEL---VYKQTKIISSNQ 350 + F IL+ ++H+ + MT+ KI H L + ++T I + +Q Sbjct: 291 KQPRCFVLMDHILNLKIVHILN---MTSAKIISFLLPPDESLHSLQSRIERETGINTGSQ 347 Query: 351 ELIYE 355 EL+ E Sbjct: 348 ELLSE 352 >3QA8-A nrPDB Length = 676 Score = 120 bits (301), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 78/248 (31%), Positives = 117/248 (47%), Gaps = 19/248 (7%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIV 68 W + + LG G V R H+ TG+ AIK + + E +++KKLNH N+V Sbjct: 16 WEMKERLGTGGFGYVLRWIHQDTGEQVAIKQCRQELSPKNRERWCLEIQIMKKLNHPNVV 75 Query: 69 KLF----AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 124 +++ +L ME+C G L L + N GL E +L D+ + Sbjct: 76 SAREVPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGPIRTLLSDISSALR 135 Query: 125 HLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDM 184 +L EN I+HRD+KP NI+ G + ++K+ D G A+EL+ E GT +YL P++ Sbjct: 136 YLHENRIIHRDLKPENIVLQPGPQ-RLIHKIIDLGYAKELDQGELCTEFVGTLQYLAPEL 194 Query: 185 YERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRP------FEGPRRNKEVMYKII 238 E QKKY TVD WS G + TG PF P + G R K + ++ Sbjct: 195 LE--------QKKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHGKVREKSNEHIVV 246 Query: 239 TGKPSGAI 246 +GA+ Sbjct: 247 YDDLTGAV 254 >4WNO-A nrPDB Length = 287 Score = 115 bits (287), Expect = 8e-26, Method: Compositional matrix adjust. Identities = 74/217 (34%), Positives = 109/217 (50%), Gaps = 21/217 (9%) Query: 13 DILGQGATANVFRGRHKKTGDL-FAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLF 71 D++G GA A VF+GRH+ DL A+K N + + + +E ++LK+L H+NIV L+ Sbjct: 24 DLIGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALY 83 Query: 72 AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGI 131 +E + + L+ME+C G L L L E + L+ + G M L GI Sbjct: 84 DFQEMANSVY--LVMEYCNGGDLADYLHAMRT---LSEDTIRLFLQQIAGAMRLLHSKGI 138 Query: 132 VHRDIKPGNIM------RVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMY 185 +HRD+KP NI+ R + V K+ DFG AR L+ + +L G+ Y+ P+ Sbjct: 139 IHRDLKPQNILLSNPAGRRANPNSIRV-KIADFGFARYLQSNMMAATLCGSPMYMAPE-- 195 Query: 186 ERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFR 222 V+ H Y DLWSIG Y TG PF+ Sbjct: 196 ---VIMSQH---YDGKADLWSIGTIVYQCLTGKAPFQ 226 >6QAU-A nrPDB Length = 280 Score = 112 bits (281), Expect = 4e-25, Method: Compositional matrix adjust. Identities = 73/216 (33%), Positives = 105/216 (48%), Gaps = 19/216 (8%) Query: 13 DILGQGATANVFRGRHKKTGDL-FAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLF 71 D++G GA A VFRGRH++ D AIK N + + + +E ++LK+L H+NIV L+ Sbjct: 17 DLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKILKELQHENIVALY 76 Query: 72 AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGI 131 ++E + L+ME+C G L L+ L E + L + M L GI Sbjct: 77 DVQELPNS--VFLVMEYCNGGDLADYLQAKGT---LSEDTIRVFLHQIAAAMRILHSKGI 131 Query: 132 VHRDIKPGNIMRVIGEDGQSVY-----KLTDFGAARELEDDEQFVSLYGTEEYLHPDMYE 186 +HRD+KP NI+ +S K+ DFG AR L + L G+ Y+ P+ Sbjct: 132 IHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAADLCGSPMYMAPE--- 188 Query: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFR 222 V+ H Y A DLWSIG Y G PF+ Sbjct: 189 --VIMSQH---YDAKADLWSIGTVIYQCLVGKPPFQ 219 >2JAM-A nrPDB Length = 304 Score = 110 bits (275), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 76/222 (34%), Positives = 116/222 (52%), Gaps = 17/222 (7%) Query: 1 MQSTS-NHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVL 59 MQ+T+ ++ ++LG GA + VF + + TG LFA+K R ++ E VL Sbjct: 2 MQTTNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSSLE-NEIAVL 60 Query: 60 KKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDV 119 KK+ H+NIV L I E TT H L+M+ G L+ + E Y E + +V++ V Sbjct: 61 KKIKHENIVTLEDIYESTT--HYYLVMQLVSGGELFDRILE-RGVYT--EKDASLVIQQV 115 Query: 120 VGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEY 179 + + +L ENGIVHRD+KP N++ + E+ + +TDFG ++ +E + + GT Y Sbjct: 116 LSAVKYLHENGIVHRDLKPENLLYLTPEENSKI-MITDFGLSK-MEQNGIMSTACGTPGY 173 Query: 180 LHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 + P++ QK Y VD WSIGV Y G PF Sbjct: 174 VAPEVLA--------QKPYSKAVDCWSIGVITYILLCGYPPF 207 >5XZW-A nrPDB Length = 471 Score = 107 bits (268), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 69/218 (31%), Positives = 118/218 (54%), Gaps = 14/218 (6%) Query: 10 LLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVK 69 ++ +++GQGA A V + + TG FA+K+ + + +D RE EVL+KLNH IV+ Sbjct: 199 IIDEVVGQGAFATVKKAIERTTGKTFAVKIISKRKVIGNMDGVTRELEVLQKLNHPRIVR 258 Query: 70 LFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYG-LPESEFLIVLRDVVGGMNHLRE 128 L E+T + + ++MEF G L + A+G + E + R ++ + ++ Sbjct: 259 LKGFYEDTESYY--MVMEFVSGGDLMDFVA----AHGAVGEDAGREISRQILTAIKYIHS 312 Query: 129 NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMY--- 185 GI HRD+KP NI+ I +D + K+TDFG A+ + + GT Y+ P++ Sbjct: 313 MGISHRDLKPDNIL--IEQDDPVLVKITDFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGK 370 Query: 186 ERAVLRKDHQKK--YGATVDLWSIGVTFYHAATGSLPF 221 + +V +++++ Y + VD+WS+G Y TG LPF Sbjct: 371 DTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPF 408 >5ES1-A nrPDB Length = 328 Score = 103 bits (257), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 70/216 (32%), Positives = 107/216 (49%), Gaps = 21/216 (9%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHKN 66 + L +G+G A V RH TG AIK+ + L P +Q RE ++K LNH N Sbjct: 17 YRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQ-LNPSSLQKLFREVRIMKGLNHPN 75 Query: 67 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 126 IVKLF + E T + L+ME+ G ++ L + E E R +V +++ Sbjct: 76 IVKLFEVIETEKTLY--LVMEYASAGEVFDYLVSHGR---MKEKEARAKFRQIVSAVHYC 130 Query: 127 RENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYE 186 + IVHRD+K N++ D ++ K+ DFG + E + + G+ Y P++++ Sbjct: 131 HQKNIVHRDLKAENLLL----DAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQ 186 Query: 187 RAVLRKDHQKKY-GATVDLWSIGVTFYHAATGSLPF 221 KKY G VD+WS+GV Y +GSLPF Sbjct: 187 --------GKKYDGPEVDIWSLGVILYTLVSGSLPF 214 >2HAK-A nrPDB Length = 328 Score = 103 bits (256), Expect = 4e-22, Method: Compositional matrix adjust. Identities = 77/237 (32%), Positives = 119/237 (50%), Gaps = 27/237 (11%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHKN 66 + L +G+G A V RH TG A+K+ + L P +Q RE ++K LNH N Sbjct: 17 YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQ-LNPTSLQKLFREVRIMKILNHPN 75 Query: 67 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYG-LPESEFLIVLRDVVGGMNH 125 IVKLF + E T + L+ME+ G ++ L A+G + E E R +V + + Sbjct: 76 IVKLFEVIETEKTLY--LVMEYASGGEVFDYLV----AHGRMKEKEARAKFRQIVSAVQY 129 Query: 126 LRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMY 185 + IVHRD+K N++ DG K+ DFG + E + + G+ Y P+++ Sbjct: 130 CHQKYIVHRDLKAENLLL----DGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELF 185 Query: 186 ERAVLRKDHQKKY-GATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 241 + KKY G VD+WS+GV Y +GSL PF+G + KE+ +++ GK Sbjct: 186 Q--------GKKYDGPEVDVWSLGVILYTLVSGSL---PFDG-QNLKELRERVLRGK 230 >6C9D-A nrPDB Length = 459 Score = 103 bits (256), Expect = 4e-22, Method: Compositional matrix adjust. Identities = 77/237 (32%), Positives = 118/237 (49%), Gaps = 27/237 (11%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHKN 66 + L +G+G A V RH TG A+K+ + L P +Q RE ++K LNH N Sbjct: 23 YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQ-LNPTSLQKLFREVRIMKILNHPN 81 Query: 67 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYG-LPESEFLIVLRDVVGGMNH 125 IVKLF + E T + L+ME+ G ++ L A+G + E E R +V + + Sbjct: 82 IVKLFEVIETEKTLY--LVMEYASGGEVFDYLV----AHGRMKEKEARAKFRQIVSAVQY 135 Query: 126 LRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMY 185 + IVHRD+K N++ DG K+ DFG + E + G+ Y P+++ Sbjct: 136 CHQKYIVHRDLKAENLLL----DGDMNIKIADFGFSNEFTVGNKLDEFCGSPPYAAPELF 191 Query: 186 ERAVLRKDHQKKY-GATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 241 + KKY G VD+WS+GV Y +GSL PF+G + KE+ +++ GK Sbjct: 192 Q--------GKKYDGPEVDVWSLGVILYTLVSGSL---PFDG-QNLKELRERVLRGK 236 >4PDS-A nrPDB Length = 347 Score = 102 bits (254), Expect = 5e-22, Method: Compositional matrix adjust. Identities = 67/218 (30%), Positives = 117/218 (53%), Gaps = 14/218 (6%) Query: 10 LLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVK 69 ++ +++GQGA A V + + TG F++K+ + + +D RE EVL+KLNH IV+ Sbjct: 34 IIDEVVGQGAFATVKKAIERTTGKTFSVKIISKRKVIGNMDGVTRELEVLQKLNHPRIVR 93 Query: 70 LFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYG-LPESEFLIVLRDVVGGMNHLRE 128 L E+T + + ++MEF G L + A+G + E + R ++ + ++ Sbjct: 94 LKGFYEDTESYY--MVMEFVSGGDLMDFVA----AHGAVGEDAGREISRQILTAIKYIHS 147 Query: 129 NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMY--- 185 GI HRD+KP NI+ I +D + K+T FG A+ + + GT Y+ P++ Sbjct: 148 MGISHRDLKPDNIL--IEQDDPVLVKITAFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGK 205 Query: 186 ERAVLRKDHQKK--YGATVDLWSIGVTFYHAATGSLPF 221 + +V +++++ Y + VD+WS+G Y TG LPF Sbjct: 206 DTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPF 243 >2QNJ-A nrPDB Length = 328 Score = 100 bits (249), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 77/237 (32%), Positives = 116/237 (48%), Gaps = 27/237 (11%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHKN 66 + L +G+G A V RH TG AIK+ + L P +Q RE ++K LNH N Sbjct: 14 YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQ-LNPTSLQKLFREVRIMKILNHPN 72 Query: 67 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYG-LPESEFLIVLRDVVGGMNH 125 IVKLF + E T + LIME+ G ++ L A+G + E E R +V + + Sbjct: 73 IVKLFEVIETEKTLY--LIMEYASGGEVFDYLV----AHGRMKEKEARSKFRQIVSAVQY 126 Query: 126 LRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMY 185 + IVHRD+K N++ D K+ DFG + E + + G+ Y P+++ Sbjct: 127 CHQKRIVHRDLKAENLLL----DADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELF 182 Query: 186 ERAVLRKDHQKKY-GATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 241 + KKY G VD+WS+GV Y +GSLPF + KE+ +++ GK Sbjct: 183 Q--------GKKYDGPEVDVWSLGVILYTLVSGSLPF----DGQNLKELRERVLRGK 227 >5FG8-A nrPDB Length = 285 Score = 99.4 bits (246), Expect = 6e-21, Method: Compositional matrix adjust. Identities = 74/211 (35%), Positives = 110/211 (52%), Gaps = 20/211 (9%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQM--REFEVLKKLNHKNIVKLF- 71 LG+GA + V R K TG FA K+ N L D Q RE + +KL+H NIV+L Sbjct: 22 LGKGAFSIVKRCVQKSTGFEFAAKIINTKK-LTARDFQKLEREARICRKLHHPNIVRLHD 80 Query: 72 AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGI 131 +I+EE + L+ + G L+ E+ E++ ++ ++ +NH +NG+ Sbjct: 81 SIQEEN---YHYLVFDLVTGGELF---EDIVAREFYSEADASHCIQQILESVNHCHQNGV 134 Query: 132 VHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQ-FVSLYGTEEYLHPDMYERAVL 190 VHRD+KP N++ G +V KL DFG A E++ D Q + GT YL P+ VL Sbjct: 135 VHRDLKPENLLLASKAKGAAV-KLADFGLAIEVQGDHQAWFGFAGTPGYLSPE-----VL 188 Query: 191 RKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 +K+ YG +VD+W+ GV Y G PF Sbjct: 189 KKE---PYGKSVDIWACGVILYILLVGYPPF 216 >3IS5-A nrPDB Length = 285 Score = 97.8 bits (242), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 65/222 (29%), Positives = 104/222 (46%), Gaps = 13/222 (5%) Query: 1 MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLK 60 Q T + L++ LG GA +V + +G IK N P++ E EVLK Sbjct: 16 FQGTIDDLFIFKRKLGSGAFGDVHLVEERSSGLERVIKTINKDRSQVPMEQIEAEIEVLK 75 Query: 61 KLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYT-VLEEPSNAYGLPESEFLIVLRDV 119 L+H NI+K+F + E+ + ++ME C G L ++ + L E +++ + Sbjct: 76 SLDHPNIIKIFEVFEDYHNMY--IVMETCEGGELLERIVSAQARGKALSEGYVAELMKQM 133 Query: 120 VGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEY 179 + + + +VH+D+KP NI+ S K+ DFG A + DE + GT Y Sbjct: 134 MNALAYFHSQHVVHKDLKPENIL-FQDTSPHSPIKIIDFGLAELFKSDEHSTNAAGTALY 192 Query: 180 LHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 + P++++R V K D+WS GV Y TG LPF Sbjct: 193 MAPEVFKRDVTFK---------CDIWSAGVVMYFLLTGCLPF 225 >5KZ7-A nrPDB Length = 346 Score = 96.7 bits (239), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 76/239 (31%), Positives = 119/239 (49%), Gaps = 31/239 (12%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFN----NISFLRPVDVQMREFEVLKKLNH 64 + L +G+G A V RH TG A+K+ + N S L+ + RE ++K LNH Sbjct: 35 YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKL---FREVRIMKVLNH 91 Query: 65 KNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYG-LPESEFLIVLRDVVGGM 123 NIVKLF + E T + L+ME+ G ++ L A+G + E E R +V + Sbjct: 92 PNIVKLFEVIETEKTLY--LVMEYASGGEVFDYLV----AHGRMKEKEARAKFRQIVSAV 145 Query: 124 NHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPD 183 + + IVHRD+K N++ D K+ DFG + E + + G+ Y P+ Sbjct: 146 QYCHQKFIVHRDLKAENLLL----DADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPE 201 Query: 184 MYERAVLRKDHQKKY-GATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 241 +++ KKY G VD+WS+GV Y +GSL PF+G + KE+ +++ GK Sbjct: 202 LFQ--------GKKYDGPEVDVWSLGVILYTLVSGSL---PFDG-QNLKELRERVLRGK 248 >4MVF-A nrPDB Length = 506 Score = 96.7 bits (239), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 72/234 (30%), Positives = 114/234 (48%), Gaps = 22/234 (9%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIV 68 +++ + LGQG V++G K T L+AIK L+ ++ +E E++KKL+H NIV Sbjct: 59 YIIDEKLGQGTYGCVYKGIDKVTNQLYAIKE-EKKDRLKNINRFFQEIEIMKKLDHPNIV 117 Query: 69 KLFAIEEETTTRHKVLIMEFCPCGSLY-TVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 127 KL+ E + LIME C L+ +++E S E +++ + + +L Sbjct: 118 KLYETYE--NDNYIYLIMELCSGRELFDSIIENGS----FTEKNAATIMKQIFSAIFYLH 171 Query: 128 ENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYER 187 IVHRD+KP N + E+ S+ K+ DFG ++ L E + GT Y+ P + + Sbjct: 172 SLNIVHRDLKPENFL-FQSENKDSLLKIIDFGLSKNLGTGEFTTTKAGTPYYVAPQVLD- 229 Query: 188 AVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 241 KY D+WS GV Y G + PF G N EV+ K+ G+ Sbjct: 230 --------GKYDKKCDIWSSGVIMYTLLCG---YPPFYGDTDN-EVLKKVKKGE 271 >2Z7Q-A nrPDB Length = 321 Score = 96.7 bits (239), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 82/246 (33%), Positives = 125/246 (50%), Gaps = 29/246 (11%) Query: 2 QSTSNHLWLLSDILGQGATANVFRGR---HKKTGDLFAIKVFNNISFLRPVDVQMR-EFE 57 ++ +H LL +LGQG+ VF R +G L+A+KV + V+ + E + Sbjct: 24 KADPSHFELLK-VLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERD 82 Query: 58 VLKKLNHKNIVKL-FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVL 116 +L +NH +VKL +A + E LI++F G L+T L S E + L Sbjct: 83 ILADVNHPFVVKLHYAFQTEGKL---YLILDFLRGGDLFTRL---SKEVMFTEEDVKFYL 136 Query: 117 RDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFV-SLYG 175 ++ G++HL GI++RD+KP NI+ + E+G KLTDFG ++E D E+ S G Sbjct: 137 AELALGLDHLHSLGIIYRDLKPENIL--LDEEGH--IKLTDFGLSKEAIDHEKKAYSFCG 192 Query: 176 TEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMY 235 T EY+ P++ R + + + D WS GV + TGSL PF+G R KE M Sbjct: 193 TVEYMAPEVVNR--------QGHSHSADWWSYGVLMFEMLTGSL---PFQGKDR-KETMT 240 Query: 236 KIITGK 241 I+ K Sbjct: 241 LILKAK 246 >3KK8-A nrPDB Length = 284 Score = 95.9 bits (237), Expect = 5e-20, Method: Compositional matrix adjust. Identities = 73/210 (34%), Positives = 105/210 (50%), Gaps = 19/210 (9%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQM--REFEVLKKLNHKNIVKLF- 71 LG+GA + V R HK TG FA K+ N L D Q RE + +KL H NIV+L Sbjct: 14 LGKGAFSVVRRCVHKTTGLEFAAKIINTKK-LSARDFQKLEREARICRKLQHPNIVRLHD 72 Query: 72 AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGI 131 +I+EE+ L+ + G L+ E+ E++ ++ ++ + + NGI Sbjct: 73 SIQEES---FHYLVFDLVTGGELF---EDIVAREFYSEADASHCIQQILESIAYCHSNGI 126 Query: 132 VHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLR 191 VHR++KP N++ G +V KL DFG A E+ D E + GT YL P+ VL+ Sbjct: 127 VHRNLKPENLLLASKAKGAAV-KLADFGLAIEVNDSEAWHGFAGTPGYLSPE-----VLK 180 Query: 192 KDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 KD Y VD+W+ GV Y G PF Sbjct: 181 KD---PYSKPVDIWACGVILYILLVGYPPF 207 >2BDW-A nrPDB Length = 362 Score = 95.9 bits (237), Expect = 6e-20, Method: Compositional matrix adjust. Identities = 73/210 (34%), Positives = 105/210 (50%), Gaps = 19/210 (9%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQM--REFEVLKKLNHKNIVKLF- 71 LG+GA + V R HK TG FA K+ N L D Q RE + +KL H NIV+L Sbjct: 37 LGKGAFSVVRRCVHKTTGLEFAAKIINTKK-LSARDFQKLEREARICRKLQHPNIVRLHD 95 Query: 72 AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGI 131 +I+EE+ L+ + G L+ E+ E++ ++ ++ + + NGI Sbjct: 96 SIQEES---FHYLVFDLVTGGELF---EDIVAREFYSEADASHCIQQILESIAYCHSNGI 149 Query: 132 VHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLR 191 VHR++KP N++ G +V KL DFG A E+ D E + GT YL P+ VL+ Sbjct: 150 VHRNLKPENLLLASKAKGAAV-KLADFGLAIEVNDSEAWHGFAGTPGYLSPE-----VLK 203 Query: 192 KDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 KD Y VD+W+ GV Y G PF Sbjct: 204 KD---PYSKPVDIWACGVILYILLVGYPPF 230 >3ZDU-A nrPDB Length = 325 Score = 95.1 bits (235), Expect = 9e-20, Method: Compositional matrix adjust. Identities = 71/235 (30%), Positives = 114/235 (48%), Gaps = 41/235 (17%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVD----VQMREFEVLKKLNHKNIVKL 70 +G+G+ V + +HK TG + AIK+F + RP + MRE + LK+ +H+N+V L Sbjct: 11 VGEGSYGTVMKCKHKNTGQIVAIKIF----YERPEQSVNKIAMREIKFLKQFHHENLVNL 66 Query: 71 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSN-AYGLPESEFLIVLRDVVGGMNHLREN 129 + + H L+ EF +TVL+E + +GL L ++ +++L N Sbjct: 67 IEVFRQKKKIH--LVFEFID----HTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSN 120 Query: 130 GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELE------DDEQFVSLYGTEEYLHPD 183 I+HRDIKP NI+ + + G + KL DFG AR L DDE Y E + D Sbjct: 121 NIIHRDIKPENIL--VSQSG--ITKLCDFGFARTLAAPGDIYDDEVATRWYRAPELVLKD 176 Query: 184 MYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKII 238 YG VD+W++G ATG+ P+ + ++++KI+ Sbjct: 177 T------------SYGKPVDIWALGCMIIEMATGN----PYLPSSSDLDLLHKIV 215 >4RGJ-A nrPDB Length = 520 Score = 95.1 bits (235), Expect = 9e-20, Method: Compositional matrix adjust. Identities = 61/210 (29%), Positives = 100/210 (47%), Gaps = 16/210 (7%) Query: 14 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHKNIVKLF 71 ILG+G+ V R K TG +AIKV + R D + +RE E+LK L+H NI+KL+ Sbjct: 67 ILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKESLLREVELLKMLDHINIMKLY 126 Query: 72 AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGI 131 E+ + L+ + G L+ + Y + + +++ ++ G+ ++ +N + Sbjct: 127 EFFEDNNYYY--LVSDVYTGGELFDEIISRKRFYEIDAAR---IIKQILSGITYMHKNNV 181 Query: 132 VHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLR 191 VHRD+KP NI+ + K+ DFG + E ++ GT Y+ PD+ Sbjct: 182 VHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEYSKKMKDKIGTAYYIAPDVLHGT--- 238 Query: 192 KDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 Y D+WS GV Y +G PF Sbjct: 239 ------YDEKCDIWSCGVILYILLSGCPPF 262 >3LIJ-A nrPDB Length = 494 Score = 94.7 bits (234), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 71/228 (31%), Positives = 117/228 (51%), Gaps = 20/228 (8%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQM-REFEVLKKLNHKNIVKLFAI 73 LG GA V R K T AIK+ S + ++ E VLK L+H NI+KL+ Sbjct: 45 LGSGAYGEVLLCRDKVTHVERAIKIIRKTSVSTSSNSKLLEEVAVLKLLDHPNIMKLYDF 104 Query: 74 EEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVH 133 E+ R+ L+ME G L+ +E + E + ++++ V+ G+ +L ++ IVH Sbjct: 105 FEDK--RNYYLVMECYKGGELF---DEIIHRMKFNEVDAAVIIKQVLSGVTYLHKHNIVH 159 Query: 134 RDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKD 193 RD+KP N++ + ++ ++ K+ DFG + E+ ++ GT Y+ P+ VLR Sbjct: 160 RDLKPENLL-LESKEKDALIKIVDFGLSAVFENQKKMKERLGTAYYIAPE-----VLR-- 211 Query: 194 HQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 241 KKY D+WSIGV + G PF G + ++E++ K+ GK Sbjct: 212 --KKYDEKCDVWSIGVILFILLAGYPPF----GGQTDQEILRKVEKGK 253 >3NCG-A nrPDB Length = 486 Score = 94.7 bits (234), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 84/305 (27%), Positives = 140/305 (45%), Gaps = 50/305 (16%) Query: 14 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFL-RPVDVQMREFEVLKKLNHKNIVKLFA 72 +LG+G+ V + + + T +A+KV N S + +RE E+LKKL+H NI+KLF Sbjct: 29 MLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLDHPNIMKLFE 88 Query: 73 IEEETTTRHKVLIMEFCPCGSLYT---VLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN 129 I E++++ F G LYT + +E E + +++ V G+ ++ ++ Sbjct: 89 ILEDSSS--------FYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMHKH 140 Query: 130 GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAV 189 IVHRD+KP NI+ E + K+ DFG + + + + GT Y+ P+ V Sbjct: 141 NIVHRDLKPENILLESKEKDCDI-KIIDFGLSTCFQQNTKMKDRIGTAYYIAPE-----V 194 Query: 190 LRKDHQKKYGATVDLWSIGVTFYHAATGSLPF----------------RPFEGPR----- 228 LR + +K D+WS GV Y +G+ PF F+ P+ Sbjct: 195 LRGTYDEK----CDVWSAGVILYILLSGTPPFYGKNEYDILKRVETGKYAFDLPQWRTIS 250 Query: 229 -RNKEVMYKIITGKPSGAISGVQKAENGPID-WSGDMPVSCSLSRGLQVLLTPVLANILE 286 K+++ K++T PS I+ Q E+ I +S + P L L + NI + Sbjct: 251 DDAKDLIRKMLTFHPSLRITATQCLEHPWIQKYSSETPTISDLPS-----LESAMTNIRQ 305 Query: 287 ADQEK 291 EK Sbjct: 306 FQAEK 310 >6CMJ-A nrPDB Length = 321 Score = 94.4 bits (233), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 63/224 (28%), Positives = 110/224 (49%), Gaps = 24/224 (10%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLR----------PVDVQMREFEV 58 + L D +G+G+ V ++ +A+KV + +R P++ +E + Sbjct: 36 YTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGGCIQPRGPIEQVYQEIAI 95 Query: 59 LKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRD 118 LKKL+H N+VKL + ++ H ++ E G V+E P+ L E + +D Sbjct: 96 LKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGP---VMEVPT-LKPLSEDQARFYFQD 151 Query: 119 VVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVS-LYGTE 177 ++ G+ +L I+HRDIKP N++ +GEDG K+ DFG + E + + +S GT Sbjct: 152 LIKGIEYLHYQKIIHRDIKPSNLL--VGEDGH--IKIADFGVSNEFKGSDALLSNTVGTP 207 Query: 178 EYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 ++ P+ L + + G +D+W++GVT Y G PF Sbjct: 208 AFMAPES-----LSETRKIFSGKALDVWAMGVTLYCFVFGQCPF 246 >3DFA-A nrPDB Length = 286 Score = 94.4 bits (233), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 70/245 (28%), Positives = 121/245 (49%), Gaps = 26/245 (10%) Query: 1 MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFL-RPVDVQMREFEVL 59 Q T + + +LG+G+ V + + + T +A+KV N S + +RE E+L Sbjct: 16 FQGTFAERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELL 75 Query: 60 KKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYT---VLEEPSNAYGLPESEFLIVL 116 KKL+H NI+KLF I E++++ F G LYT + +E E + ++ Sbjct: 76 KKLDHPNIMKLFEILEDSSS--------FYIVGELYTGGELFDEIIKRKRFSEHDAARII 127 Query: 117 RDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGT 176 + V G+ ++ ++ IVHRD+KP NI+ E + K+ DFG + + + + GT Sbjct: 128 KQVFSGITYMHKHNIVHRDLKPENILLESKEKDCDI-KIIDFGLSTCFQQNTKMKDRIGT 186 Query: 177 EEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYK 236 Y+ P+ VLR + +K D+WS GV Y +G+ PF + +++ + Sbjct: 187 AYYIAPE-----VLRGTYDEK----CDVWSAGVILYILLSGTPPFY----GKNEYDILKR 233 Query: 237 IITGK 241 + TGK Sbjct: 234 VETGK 238 >6FDY-U nrPDB Length = 276 Score = 94.0 bits (232), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 85/294 (28%), Positives = 133/294 (45%), Gaps = 43/294 (14%) Query: 9 WLLSDILGQGATANVFRGRHKK-TGDLFAIKVFNNISFLRP-VDVQMREFEVLKKLNHKN 66 ++L++ LG G A V++ KK T ++ AIK S + V+ + E E+LK + H + Sbjct: 13 FILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKGIRHPH 72 Query: 67 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 126 IV+L + ++ + LIMEFC G L + LPE + ++ + + L Sbjct: 73 IVQLKDFQWDSDNIY--LIMEFCAGGDLSRFIH---TRRILPEKVARVFMQQLASALQFL 127 Query: 127 RENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYE 186 E I H D+KP NI+ + + KL DFG A+ + ++ L G+ Y+ P+M Sbjct: 128 HERNISHLDLKPQNIL--LSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMV- 184 Query: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAI 246 Q++Y A VDLWS+GV Y A G PF R E+ KI + + Sbjct: 185 -------CQRQYDARVDLWSMGVILYEALFGQPPF----ASRSFSELEEKIRSNR----- 228 Query: 247 SGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFA 300 ++P+ LSR + LL +LE D + F FFA Sbjct: 229 -------------VIELPLRPLLSRDCRDLLQ----RLLERDPSRRISFQDFFA 265 >2J90-A nrPDB Length = 304 Score = 93.6 bits (231), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 72/226 (31%), Positives = 107/226 (47%), Gaps = 18/226 (7%) Query: 1 MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNN---ISFLRPVDVQM--RE 55 QS + + + LG G A V + R K TG +A K S R V + RE Sbjct: 20 FQSMVEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIERE 79 Query: 56 FEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIV 115 +L+++ H NI+ L I E T VLI+E G L+ L E + L E E Sbjct: 80 VNILREIRHPNIITLHDIFENKTD--VVLILELVSGGELFDFLAEKES---LTEDEATQF 134 Query: 116 LRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYG 175 L+ ++ G+++L I H D+KP NIM + KL DFG A ++E +F +++G Sbjct: 135 LKQILDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFG 194 Query: 176 TEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 T E++ P++ L G D+WSIGV Y +G+ PF Sbjct: 195 TPEFVAPEIVNYEPL--------GLEADMWSIGVITYILLSGASPF 232 >2VN9-A nrPDB Length = 301 Score = 92.8 bits (229), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 74/211 (35%), Positives = 104/211 (49%), Gaps = 20/211 (9%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQM--REFEVLKKLNHKNIVKLF- 71 LG+GA + V R TG +A K+ N L D Q RE + + L H NIV+L Sbjct: 12 LGKGAFSVVRRCMKIPTGQEYAAKIINTKK-LSARDHQKLEREARICRLLKHPNIVRLHD 70 Query: 72 AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGI 131 +I EE L+ + G L+ E+ E++ ++ ++ +NH NGI Sbjct: 71 SISEEG---FHYLVFDLVTGGELF---EDIVAREYYSEADASHCIQQILESVNHCHLNGI 124 Query: 132 VHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQ-FVSLYGTEEYLHPDMYERAVL 190 VHRD+KP N++ G +V KL DFG A E++ D+Q + GT YL P+ VL Sbjct: 125 VHRDLKPENLLLASKSKGAAV-KLADFGLAIEVQGDQQAWFGFAGTPGYLSPE-----VL 178 Query: 191 RKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 RKD YG VD+W+ GV Y G PF Sbjct: 179 RKD---PYGKPVDMWACGVILYILLVGYPPF 206 >2YAB-A nrPDB Length = 361 Score = 92.4 bits (228), Expect = 6e-19, Method: Compositional matrix adjust. Identities = 70/212 (33%), Positives = 105/212 (49%), Gaps = 18/212 (8%) Query: 15 LGQGATANVFRGRHKKTGDLFA---IKVFNNISFLRPVDVQM--REFEVLKKLNHKNIVK 69 LG G A V + R K TG +A IK + + R V + RE +L+++ H NI+ Sbjct: 20 LGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIEREVSILRQVLHPNIIT 79 Query: 70 LFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN 129 L + E T VLI+E G L+ L + + L E E ++ ++ G+N+L Sbjct: 80 LHDVYENRT--DVVLILELVSGGELFDFLAQKES---LSEEEATSFIKQILDGVNYLHTK 134 Query: 130 GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAV 189 I H D+KP NIM + KL DFG A E+ED +F +++GT E++ P++ Sbjct: 135 KIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYEP 194 Query: 190 LRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 L G D+WSIGV Y +G+ PF Sbjct: 195 L--------GLEADMWSIGVITYILLSGASPF 218 >2Y7J-A nrPDB Length = 365 Score = 92.4 bits (228), Expect = 6e-19, Method: Compositional matrix adjust. Identities = 66/217 (30%), Positives = 108/217 (49%), Gaps = 19/217 (8%) Query: 13 DILGQGATANVFRGRHKKTGDLFAIKVFN-NISFLRPVDVQ------MREFEVLKKL-NH 64 D++G+G ++ V R H+ TG FA+K+ L P ++ RE +L+++ H Sbjct: 100 DVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHILRQVAGH 159 Query: 65 KNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 124 +I+ L I+ ++ L+ + G L+ L E L E E ++R ++ ++ Sbjct: 160 PHIITL--IDSYESSSFMFLVFDLMRKGELFDYLTE---KVALSEKETRSIMRSLLEAVS 214 Query: 125 HLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDM 184 L N IVHRD+KP NI+ D +L+DFG + LE E+ L GT YL P++ Sbjct: 215 FLHANNIVHRDLKPENILL----DDNMQIRLSDFGFSCHLEPGEKLRELCGTPGYLAPEI 270 Query: 185 YERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 + ++ + YG VDLW+ GV + GS PF Sbjct: 271 LKCSM--DETHPGYGKEVDLWACGVILFTLLAGSPPF 305 >2A27-A nrPDB Length = 321 Score = 92.0 bits (227), Expect = 7e-19, Method: Compositional matrix adjust. Identities = 70/225 (31%), Positives = 109/225 (48%), Gaps = 18/225 (8%) Query: 2 QSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFA---IKVFNNISFLRPVDVQM--REF 56 Q + + + LG G A V + R K TG +A IK + + R V + RE Sbjct: 7 QQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREV 66 Query: 57 EVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVL 116 +L+++ H N++ L + E T VLI+E G L+ L + + L E E + Sbjct: 67 SILRQVLHHNVITLHDVYENRTD--VVLILELVSGGELFDFLAQKES---LSEEEATSFI 121 Query: 117 RDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGT 176 + ++ G+N+L I H D+KP NIM + KL DFG A E+ED +F +++GT Sbjct: 122 KQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGT 181 Query: 177 EEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 E++ P++ L G D+WSIGV Y +G+ PF Sbjct: 182 PEFVAPEIVNYEPL--------GLEADMWSIGVITYILLSGASPF 218 >1ZWS-A nrPDB Length = 288 Score = 92.0 bits (227), Expect = 9e-19, Method: Compositional matrix adjust. Identities = 70/225 (31%), Positives = 109/225 (48%), Gaps = 18/225 (8%) Query: 2 QSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFA---IKVFNNISFLRPVDVQM--REF 56 Q + + + LG G A V + R K TG +A IK + + R V + RE Sbjct: 7 QQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREV 66 Query: 57 EVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVL 116 +L+++ H N++ L + E T VLI+E G L+ L + + L E E + Sbjct: 67 SILRQVLHHNVITLHDVYENRTD--VVLILELVSGGELFDFLAQKES---LSEEEATSFI 121 Query: 117 RDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGT 176 + ++ G+N+L I H D+KP NIM + KL DFG A E+ED +F +++GT Sbjct: 122 KQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGT 181 Query: 177 EEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 E++ P++ L G D+WSIGV Y +G+ PF Sbjct: 182 PEFVAPEIVNYEPL--------GLEADMWSIGVITYILLSGASPF 218 >3HZT-A nrPDB Length = 467 Score = 91.7 bits (226), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 70/231 (30%), Positives = 115/231 (49%), Gaps = 21/231 (9%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVF--NNISFLRPVDVQMREFEVLKKLNHKNIVKLFA 72 LG GA V + K TG AIK+ ++++ + E VLK+L+H NI+KL+ Sbjct: 12 LGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDHPNIMKLYE 71 Query: 73 IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIV 132 E+ R+ L+ME G L+ +E E + ++++ V+ G +L ++ IV Sbjct: 72 FFEDK--RNYYLVMEVYRGGELF---DEIILRQKFSEVDAAVIMKQVLSGTTYLHKHNIV 126 Query: 133 HRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRK 192 HRD+KP N++ + + ++ K+ DFG + E + GT Y+ P+ VLR Sbjct: 127 HRDLKPENLL-LESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAPE-----VLR- 179 Query: 193 DHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS 243 KKY D+WS GV Y G PF G + ++E++ ++ GK S Sbjct: 180 ---KKYDEKCDVWSCGVILYILLCGYPPF----GGQTDQEILKRVEKGKFS 223 >2UV2-A nrPDB Length = 325 Score = 91.7 bits (226), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 71/239 (29%), Positives = 115/239 (48%), Gaps = 23/239 (9%) Query: 8 LWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNI 67 W + LG GA V++ ++K+T L A KV + S ++ M E ++L +H NI Sbjct: 38 FWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKS-EEELEDYMVEIDILASCDHPNI 96 Query: 68 VKLFAIEEETTTRHKVLIMEFCPCGSLYTV---LEEPSNAYGLPESEFLIVLRDVVGGMN 124 VKL ++ + +++EFC G++ V LE P L ES+ +V + + +N Sbjct: 97 VKL--LDAFYYENNLWILIEFCAGGAVDAVMLELERP-----LTESQIQVVCKQTLDALN 149 Query: 125 HLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFG-AARELEDDEQFVSLYGTEEYLHPD 183 +L +N I+HRD+K GNI+ + D KL DFG +A+ ++ S GT ++ P Sbjct: 150 YLHDNKIIHRDLKAGNILFTLDGD----IKLADFGVSAKNTRTIQRRDSFIGTPYWMAP- 204 Query: 184 MYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKP 242 E + + Y D+WS+G+T A P P R V+ KI +P Sbjct: 205 --EVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHEL-NPMR---VLLKIAKSEP 257 >1PHK-A nrPDB Length = 298 Score = 91.7 bits (226), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 70/220 (31%), Positives = 111/220 (50%), Gaps = 24/220 (10%) Query: 13 DILGQGATANVFRGRHKKTGDLFAIKVFN----------NISFLRPVDVQMREFEVLKKL 62 +ILG+G ++ V R HK T +A+K+ + + LR + ++E ++L+K+ Sbjct: 23 EILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQELR--EATLKEVDILRKV 80 Query: 63 N-HKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVG 121 + H NI++L E T L+ + G L+ L E L E E ++R ++ Sbjct: 81 SGHPNIIQLKDTYE--TNTFFFLVFDLMKKGELFDYLTEKVT---LSEKETRKIMRALLE 135 Query: 122 GMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLH 181 + L + IVHRD+KP NI+ D KLTDFG + +L+ E+ + GT YL Sbjct: 136 VICALHKLNIVHRDLKPENILL----DDDMNIKLTDFGFSCQLDPGEKLREVCGTPSYLA 191 Query: 182 PDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 P++ E ++ D+ YG VD+WS GV Y GS PF Sbjct: 192 PEIIECSM--NDNHPGYGKEVDMWSTGVIMYTLLAGSPPF 229 >6CCF-A nrPDB Length = 290 Score = 91.7 bits (226), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 58/177 (32%), Positives = 92/177 (51%), Gaps = 14/177 (7%) Query: 46 LRPVDVQMREFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAY 105 L P++ +E +LKKL+H N+VKL + ++ + L+ + G V+E P + Sbjct: 69 LLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGP---VMEVPCDK- 124 Query: 106 GLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELE 165 E + + LRDV+ G+ +L IVHRDIKP N++ +G+DG K+ DFG + + E Sbjct: 125 PFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLL--LGDDGH--VKIADFGVSNQFE 180 Query: 166 -DDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 +D Q S GT ++ P+ + Q G +D+W+ GVT Y G PF Sbjct: 181 GNDAQLSSTAGTPAFMAPE-----AISDSGQSFSGKALDVWATGVTLYCFVYGKCPF 232 >6HXF-B nrPDB Length = 302 Score = 91.3 bits (225), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 77/257 (29%), Positives = 121/257 (47%), Gaps = 27/257 (10%) Query: 6 NHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHK 65 N +W + LG GA V++ ++K+TG L A KV S ++ + E E+L +H Sbjct: 18 NEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSE-EELEDYIVEIEILATCDHP 76 Query: 66 NIVKLFAIEEETTTRHKVLIM-EFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 124 IVKL K+ IM EFCP G++ ++ E GL E + +V R ++ +N Sbjct: 77 YIVKLLGAYYHDG---KLWIMIEFCPGGAVDAIMLELDR--GLTEPQIQVVCRQMLEALN 131 Query: 125 HLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFG-AARELEDDEQFVSLYGTEEYLHPD 183 L I+HRD+K GN++ + D +L DFG +A+ L+ ++ S GT ++ P+ Sbjct: 132 FLHSKRIIHRDLKAGNVLMTLEGD----IRLADFGVSAKNLKTLQKRDSFIGTPYWMAPE 187 Query: 184 MYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS 243 + + KD Y A D+WS+G+T A P P R V+ KI P Sbjct: 188 VVMCETM-KDTPYDYKA--DIWSLGITLIEMAQIEPPHHEL-NPMR---VLLKIAKSDPP 240 Query: 244 GAISGVQKAENGPIDWS 260 ++ P WS Sbjct: 241 TLLT--------PSKWS 249 >3DXN-A nrPDB Length = 287 Score = 90.9 bits (224), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 70/231 (30%), Positives = 115/231 (49%), Gaps = 21/231 (9%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVF--NNISFLRPVDVQMREFEVLKKLNHKNIVKLFA 72 LG GA V + K TG AIK+ ++++ + E VLK+L+H NI+KL+ Sbjct: 29 LGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDHPNIMKLYE 88 Query: 73 IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIV 132 E+ R+ L+ME G L+ +E E + ++++ V+ G +L ++ IV Sbjct: 89 FFEDK--RNYYLVMEVYRGGELF---DEIILRQKFSEVDAAVIMKQVLSGTTYLHKHNIV 143 Query: 133 HRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRK 192 HRD+KP N++ + + ++ K+ DFG + E + GT Y+ P+ VLR Sbjct: 144 HRDLKPENLL-LESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAPE-----VLR- 196 Query: 193 DHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS 243 KKY D+WS GV Y G PF G + ++E++ ++ GK S Sbjct: 197 ---KKYDEKCDVWSCGVILYILLCGYPPF----GGQTDQEILKRVEKGKFS 240 >5VO2-A nrPDB Length = 300 Score = 90.9 bits (224), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 66/210 (31%), Positives = 103/210 (49%), Gaps = 31/210 (14%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 74 +G GA VF GR G+ A+K D++ + + L+KL H NI+ + Sbjct: 20 VGSGAQGAVFLGRFH--GEEVAVKKVR--------DLKETDIKHLRKLKHPNIITFKGVC 69 Query: 75 EETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIV--LRDVVGGMNHLRENGIV 132 + ++MEFC G LY VL G P + L+V + GGMN+L + I+ Sbjct: 70 TQAPCY--CILMEFCAQGQLYEVLRA-----GRPVTPSLLVDWSMGIAGGMNYLHLHKII 122 Query: 133 HRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRK 192 HRD+K N M + +D V K++DFG ++EL D +S GT ++ P+ V+R Sbjct: 123 HRDLKSPN-MLITYDD---VVKISDFGTSKELSDKSTKMSFAGTVAWMAPE-----VIRN 173 Query: 193 DHQKKYGATVDLWSIGVTFYHAATGSLPFR 222 + VD+WS GV + TG +P++ Sbjct: 174 E---PVSEKVDIWSFGVVLWELLTGEIPYK 200 >2JC6-A nrPDB Length = 334 Score = 90.5 bits (223), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 65/211 (30%), Positives = 97/211 (45%), Gaps = 14/211 (6%) Query: 11 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKL 70 + LG GA + V K TG LFA+K + E VL+K+ H+NIV L Sbjct: 26 FKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIVAL 85 Query: 71 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 130 I E + H L+M+ G L+ + E E + ++R V+ + +L G Sbjct: 86 EDIYE--SPNHLYLVMQLVSGGELFDRIVEKG---FYTEKDASTLIRQVLDAVYYLHRMG 140 Query: 131 IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVL 190 IVHRD+KP N++ +D +S ++DFG ++ + + GT Y+ P++ Sbjct: 141 IVHRDLKPENLL-YYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLA---- 195 Query: 191 RKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 QK Y VD WSIGV Y G PF Sbjct: 196 ----QKPYSKAVDCWSIGVIAYILLCGYPPF 222 >5D9K-A nrPDB Length = 330 Score = 90.1 bits (222), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 78/237 (32%), Positives = 123/237 (51%), Gaps = 28/237 (11%) Query: 11 LSDILGQGATANVFRGRHKKTGD---LFAIKVFNNISFLRPVDVQMR-EFEVLKKLNHKN 66 L +LGQG+ VF + D L+A+KV + V+ + E ++L ++NH Sbjct: 34 LLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPF 93 Query: 67 IVKL-FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 125 IVKL +A + E LI++F G L+T L S E + L ++ ++H Sbjct: 94 IVKLHYAFQTEGKL---YLILDFLRGGDLFTRL---SKEVMFTEEDVKFYLAELALALDH 147 Query: 126 LRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARE-LEDDEQFVSLYGTEEYLHPDM 184 L GI++RD+KP NI+ + E+G KLTDFG ++E ++ +++ S GT EY+ P++ Sbjct: 148 LHSLGIIYRDLKPENIL--LDEEGH--IKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEV 203 Query: 185 YERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 241 V R+ H + + D WS GV + TG+L PF+G R KE M I+ K Sbjct: 204 ----VNRRGHTQ----SADWWSFGVLMFEMLTGTL---PFQGKDR-KETMTMILKAK 248 >4REW-A nrPDB Length = 540 Score = 90.1 bits (222), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 62/216 (28%), Positives = 104/216 (48%), Gaps = 20/216 (9%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ---MREFEVLKKLNHK 65 ++L D LG G V G+H+ TG A+K+ N +R +DV RE + LK H Sbjct: 8 YILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQK-IRSLDVVGKIRREIQNLKLFRHP 66 Query: 66 NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 125 +I+KL+ + +T ++ME+ G L+ + + L E E + + ++ G+++ Sbjct: 67 HIIKLYQVI--STPSDIFMVMEYVSGGELFDYICKNGR---LDEKESRRLFQQILSGVDY 121 Query: 126 LRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMY 185 + +VHRD+KP N++ D K+ DFG + + D E + G+ Y P++ Sbjct: 122 CHRHMVVHRDLKPENVLL----DAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVI 177 Query: 186 ERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 + G VD+WS GV Y G+LPF Sbjct: 178 SGRLYA-------GPEVDIWSSGVILYALLCGTLPF 206 >4RED-A nrPDB Length = 351 Score = 90.1 bits (222), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 62/216 (28%), Positives = 104/216 (48%), Gaps = 20/216 (9%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ---MREFEVLKKLNHK 65 ++L D LG G V G+H+ TG A+K+ N +R +DV RE + LK H Sbjct: 16 YILGDTLGVGTFGKVKVGKHELTGHAVAVKILNRQK-IRSLDVVGKIRREIQNLKLFRHP 74 Query: 66 NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 125 +I+KL+ + +T ++ME+ G L+ + + L E E + + ++ G+++ Sbjct: 75 HIIKLYQVI--STPSDIFMVMEYVSGGELFDYICKNGR---LDEKESRRLFQQILSGVDY 129 Query: 126 LRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMY 185 + +VHRD+KP N++ D K+ DFG + + D E + G+ Y P++ Sbjct: 130 CHRHMVVHRDLKPENVLL----DAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVI 185 Query: 186 ERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 + G VD+WS GV Y G+LPF Sbjct: 186 SGRLYA-------GPEVDIWSSGVILYALLCGTLPF 214 >4UZD-A nrPDB Length = 287 Score = 89.7 bits (221), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 67/220 (30%), Positives = 109/220 (49%), Gaps = 25/220 (11%) Query: 9 WLLSDI-----LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRP-VDVQMR-EFEVLKK 61 W L D LG+G NV+ R K++ + A+KV + V+ Q+R E E+ Sbjct: 5 WALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSH 64 Query: 62 LNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVG 121 L H NI++L+ + T + LI+E+ P G++Y L++ S E + ++ Sbjct: 65 LRHPNILRLYGYFHDATRVY--LILEYAPLGTVYRELQKLSK---FDEQRTATYITELAN 119 Query: 122 GMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLH 181 +++ ++HRDIKP N++ +G G+ K+ DFG + + +L GT +YL Sbjct: 120 ALSYCHSKRVIHRDIKPENLL--LGSAGE--LKIADFGWSVHAPSSRR-TTLCGTLDYLP 174 Query: 182 PDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 P+M E + H +K VDLWS+GV Y G PF Sbjct: 175 PEMIEGRM----HDEK----VDLWSLGVLCYEFLVGKPPF 206 >4CFH-A nrPDB Length = 493 Score = 89.7 bits (221), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 62/216 (28%), Positives = 104/216 (48%), Gaps = 20/216 (9%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ---MREFEVLKKLNHK 65 ++L D LG G V G+H+ TG A+K+ N +R +DV RE + LK H Sbjct: 35 YILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQK-IRSLDVVGKIRREIQNLKLFRHP 93 Query: 66 NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 125 +I+KL+ + +T ++ME+ G L+ + + L E E + + ++ G+++ Sbjct: 94 HIIKLYQVI--STPSDIFMVMEYVSGGELFDYICKNGR---LDEKESRRLFQQILSGVDY 148 Query: 126 LRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMY 185 + +VHRD+KP N++ D K+ DFG + + D E + G+ Y P++ Sbjct: 149 CHRHMVVHRDLKPENVLL----DAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVI 204 Query: 186 ERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 + G VD+WS GV Y G+LPF Sbjct: 205 SGRLYA-------GPEVDIWSSGVILYALLCGTLPF 233 >3D2K-A nrPDB Length = 272 Score = 89.7 bits (221), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 67/224 (29%), Positives = 111/224 (49%), Gaps = 25/224 (11%) Query: 5 SNHLWLLSDI-----LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRP-VDVQMR-EFE 57 S W L D LG+G NV+ R +++ + A+KV + V+ Q+R E E Sbjct: 5 SKRQWTLEDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVEHQLRREVE 64 Query: 58 VLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLR 117 + L H NI++L+ + T + LI+E+ P G++Y L++ S E + Sbjct: 65 IQSHLRHPNILRLYGYFHDATRVY--LILEYAPLGTVYRELQKLSR---FDEQRTATYIT 119 Query: 118 DVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTE 177 ++ +++ ++HRDIKP N++ +G +G+ K+ DFG + + +L GT Sbjct: 120 ELANALSYCHSKRVIHRDIKPENLL--LGSNGE--LKIADFGWSVHAPSSRR-TTLCGTL 174 Query: 178 EYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 +YL P+M E + H +K VDLWS+GV Y G PF Sbjct: 175 DYLPPEMIEGRM----HDEK----VDLWSLGVLCYEFLVGMPPF 210 >3F3Z-A nrPDB Length = 277 Score = 88.6 bits (218), Expect = 8e-18, Method: Compositional matrix adjust. Identities = 69/235 (29%), Positives = 107/235 (45%), Gaps = 20/235 (8%) Query: 6 NHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHK 65 N + L + +G+G+ V K T A K F+ VD +E E++K L+H Sbjct: 8 NQYYTLENTIGRGSWGEVKIAVQKGTRIRRAAKKIPKY-FVEDVDRFKQEIEIMKSLDHP 66 Query: 66 NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 125 NI++L+ E+ T + L+ME C G L+ E + ES+ +++DV+ + + Sbjct: 67 NIIRLYETFEDNTDIY--LVMELCTGGELF---ERVVHKRVFRESDAARIMKDVLSAVAY 121 Query: 126 LRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMY 185 + + HRD+KP N + + + S KL DFG A + + + GT Y+ P + Sbjct: 122 CHKLNVAHRDLKPENFL-FLTDSPDSPLKLIDFGLAARFKPGKMMRTKVGTPYYVSPQVL 180 Query: 186 ERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITG 240 E YG D WS GV Y G + PF P + EVM KI G Sbjct: 181 EGL---------YGPECDEWSAGVMMYVLLCG---YPPFSAP-TDSEVMLKIREG 222 >4B6L-A nrPDB Length = 281 Score = 88.6 bits (218), Expect = 8e-18, Method: Compositional matrix adjust. Identities = 66/220 (30%), Positives = 107/220 (48%), Gaps = 20/220 (9%) Query: 5 SNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKL 62 S +L +LG+G A + +TG +A+KV +P + + E E+ + L Sbjct: 7 SGRTYLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDL 66 Query: 63 NHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGG 122 H++IV+ E+ + + +E C SL + + + L E E LR ++ G Sbjct: 67 QHRHIVRFSHHFEDADNIY--IFLELCSRKSLAHIWKA---RHTLLEPEVRYYLRQILSG 121 Query: 123 MNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQF-VSLYGTEEYLH 181 + +L + GI+HRD+K GN I E+ + K+ DFG A LE EQ ++ GT Y+ Sbjct: 122 LKYLHQRGILHRDLKLGNFF--ITENME--LKVGDFGLAARLEPPEQRKKTICGTPNYVA 177 Query: 182 PDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 P++ +LR+ H G D+WS+G Y GS PF Sbjct: 178 PEV----LLRQGH----GPEADVWSLGCVMYTLLCGSPPF 209 >1KOB-A nrPDB Length = 387 Score = 88.6 bits (218), Expect = 8e-18, Method: Compositional matrix adjust. Identities = 66/207 (31%), Positives = 96/207 (46%), Gaps = 15/207 (7%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 74 LG GA V R K TG +F K N L V+ E ++ +L+H ++ L Sbjct: 59 LGSGAFGVVHRCVEKATGRVFVAKFINTPYPLDKYTVK-NEISIMNQLHHPKLINLHDAF 117 Query: 75 EETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHR 134 E+ VLI+EF G L+ + + Y + E+E + +R G+ H+ E+ IVH Sbjct: 118 EDKY--EMVLILEFLSGGELFDRIA--AEDYKMSEAEVINYMRQACEGLKHMHEHSIVHL 173 Query: 135 DIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDH 194 DIKP NIM S K+ DFG A +L DE T E+ P++ +R + Sbjct: 174 DIKPENIM--CETKKASSVKIIDFGLATKLNPDEIVKVTTATAEFAAPEIVDREPV---- 227 Query: 195 QKKYGATVDLWSIGVTFYHAATGSLPF 221 G D+W+IGV Y +G PF Sbjct: 228 ----GFYTDMWAIGVLGYVLLSGLSPF 250 >5YV8-A nrPDB Length = 298 Score = 88.6 bits (218), Expect = 9e-18, Method: Compositional matrix adjust. Identities = 63/239 (26%), Positives = 110/239 (46%), Gaps = 39/239 (16%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLR--------------------- 47 + L D +G+G+ V ++ +A+KV + +R Sbjct: 15 YTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCI 74 Query: 48 ----PVDVQMREFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSN 103 P++ +E +LKKL+H N+VKL + ++ H ++ E G V+E P+ Sbjct: 75 QPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGP---VMEVPT- 130 Query: 104 AYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARE 163 L E + +D++ G+ +L I+HRDIKP N++ +GEDG K+ DFG + E Sbjct: 131 LKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLL--VGEDGH--IKIADFGVSNE 186 Query: 164 LEDDEQFVS-LYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 + + +S GT ++ P+ L + + G +D+W++GVT Y G PF Sbjct: 187 FKGSDALLSNTVGTPAFMAPES-----LSETRKIFSGKALDVWAMGVTLYCFVFGQCPF 240 >5IG1-A nrPDB Length = 344 Score = 88.2 bits (217), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 60/211 (28%), Positives = 101/211 (47%), Gaps = 19/211 (9%) Query: 14 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQM--REFEVLKKLNHKNIVKLF 71 ++G+GA + V R +K+TG++ A+KV + LR ++ RE + L H++IV + Sbjct: 24 VIGKGAFSTVHRCVNKRTGEVCAVKVIA-LKSLRSSEINKIKREIGICSSLQHEHIVSMR 82 Query: 72 -AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 130 A +E+ H L+ E+ G L+ +E E + + ++ + H Sbjct: 83 RAFRDES---HFYLVFEYVSGGELF---DEIVTRKFYNEKDASACMHQILSALQHCHSKN 136 Query: 131 IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVL 190 I+HRD+KP N++ + +D + K+TDFG A +E + GT YL P++ R Sbjct: 137 IIHRDLKPENLL-LASKDPNAPVKITDFGLAVIMEQGPTYFGFAGTPGYLSPEVIRRV-- 193 Query: 191 RKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 Y VD+W+ GV Y G PF Sbjct: 194 ------PYDTAVDVWACGVILYILLVGYPPF 218 >4D2V-A nrPDB Length = 356 Score = 87.8 bits (216), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 62/214 (28%), Positives = 98/214 (45%), Gaps = 20/214 (9%) Query: 11 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKL 70 L + +G G A V H TG++ AIK+ + + + E E LK L H++I +L Sbjct: 33 LHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNLRHQHICQL 92 Query: 71 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 130 + + E T +++E+CP G L+ + L E E +V R +V + ++ G Sbjct: 93 YHVLE--TANKIFMVLEYCPGGELFDYIISQDR---LSEEETRVVFRQIVSAVAYVHSQG 147 Query: 131 IVHRDIKPGNIMRVIGEDGQSVYKLTDFG--AARELEDDEQFVSLYGTEEYLHPDMYERA 188 HRD+KP N++ D KL DFG A + D + G Y P++ + Sbjct: 148 YAHRDLKPENLLF----DEYHKLKLIDFGLCAKPKGNKDYHLQACCGALAYAAPELIQ-- 201 Query: 189 VLRKDHQKKY-GATVDLWSIGVTFYHAATGSLPF 221 K Y G+ D+WS+G+ Y G LPF Sbjct: 202 ------GKSYLGSEADVWSMGILLYVLMCGFLPF 229 >2YCR-A nrPDB Length = 323 Score = 87.8 bits (216), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 69/240 (28%), Positives = 112/240 (46%), Gaps = 22/240 (9%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFL----RPVDVQMR---EFEVLKK 61 +++S LG GA V +KT AIK+ + F R D + E E+LKK Sbjct: 12 YIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKK 71 Query: 62 LNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVG 121 LNH I+K I+ +++E G L+ ++ L E+ + ++ Sbjct: 72 LNHPCIIK---IKNFFDAEDYYIVLELMEGGELF---DKVVGNKRLKEATCKLYFYQMLL 125 Query: 122 GMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLH 181 + +L ENGI+HRD+KP N++ + ++ + K+TDFG ++ L + +L GT YL Sbjct: 126 AVQYLHENGIIHRDLKPENVL-LSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLA 184 Query: 182 PDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 241 P+ VL Y VD WS+GV + +G + PF R + +I +GK Sbjct: 185 PE-----VLVSVGTAGYNRAVDCWSLGVILFICLSG---YPPFSEHRTQVSLKDQITSGK 236 >2W4O-A nrPDB Length = 349 Score = 87.8 bits (216), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 67/226 (29%), Positives = 110/226 (48%), Gaps = 24/226 (10%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQM--REFEVLKKLNHKNIVKLFA 72 LG+GAT+ V+R + K T +A+KV + VD ++ E VL +L+H NI+KL Sbjct: 61 LGRGATSIVYRCKQKGTQKPYALKVLK-----KTVDKKIVRTEIGVLLRLSHPNIIKLKE 115 Query: 73 IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIV 132 I E T L++E G L+ + E E + ++ ++ + +L ENGIV Sbjct: 116 IFETPT--EISLVLELVTGGELFDRIVEKGY---YSERDAADAVKQILEAVAYLHENGIV 170 Query: 133 HRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRK 192 HRD+KP N++ + K+ DFG ++ +E ++ GT Y P++ Sbjct: 171 HRDLKPENLLYATPAPDAPL-KIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCA--- 226 Query: 193 DHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKII 238 YG VD+WS+G+ Y G F PF R ++ + +I+ Sbjct: 227 -----YGPEVDMWSVGIITYILLCG---FEPFYDERGDQFMFRRIL 264 >2VZ6-A nrPDB Length = 313 Score = 87.8 bits (216), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 74/218 (33%), Positives = 107/218 (49%), Gaps = 20/218 (9%) Query: 8 LWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQM--REFEVLKKLNHK 65 ++ L + LG+GA + V R G +A K+ N L D Q RE + + L H Sbjct: 23 MYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKK-LSARDHQKLEREARICRLLKHP 81 Query: 66 NIVKLF-AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 124 NIV+L +I EE H LI + G L+ E+ E++ ++ ++ + Sbjct: 82 NIVRLHDSISEEG---HHYLIFDLVTGGELF---EDIVAREYYSEADASHCIQQILEAVL 135 Query: 125 HLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQ-FVSLYGTEEYLHPD 183 H + G+VHRD+KP N++ G +V KL DFG A E+E ++Q + GT YL P+ Sbjct: 136 HCHQMGVVHRDLKPENLLLASKLKGAAV-KLADFGLAIEVEGEQQAWFGFAGTPGYLSPE 194 Query: 184 MYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 VLRKD YG VDLW+ GV Y G PF Sbjct: 195 -----VLRKD---PYGKPVDLWACGVILYILLVGYPPF 224 >5U6Y-A nrPDB Length = 461 Score = 87.4 bits (215), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 74/218 (33%), Positives = 107/218 (49%), Gaps = 20/218 (9%) Query: 8 LWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQM--REFEVLKKLNHK 65 ++ L + LG+GA + V R G +A K+ N L D Q RE + + L H Sbjct: 1 MYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKK-LSARDHQKLEREARICRLLKHP 59 Query: 66 NIVKLF-AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 124 NIV+L +I EE H LI + G L+ E+ E++ ++ ++ + Sbjct: 60 NIVRLHDSISEEG---HHYLIFDLVTGGELF---EDIVAREYYSEADASHCIQQILEAVL 113 Query: 125 HLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQ-FVSLYGTEEYLHPD 183 H + G+VHRD+KP N++ G +V KL DFG A E+E ++Q + GT YL P+ Sbjct: 114 HCHQMGVVHRDLKPENLLLASKLKGAAV-KLADFGLAIEVEGEQQAWFGFAGTPGYLSPE 172 Query: 184 MYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 VLRKD YG VDLW+ GV Y G PF Sbjct: 173 -----VLRKD---PYGKPVDLWACGVILYILLVGYPPF 202 >4CQG-A nrPDB Length = 331 Score = 87.0 bits (214), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 61/215 (28%), Positives = 102/215 (47%), Gaps = 22/215 (10%) Query: 11 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKL 70 L + +G G A V H TG++ AIK+ + + + E + LK L H++I +L Sbjct: 13 LYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGSDLPRVKTEIDALKSLRHQHICQL 72 Query: 71 FAIEEETTTRHKV-LIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN 129 + + E T++K+ +++E+CP G L+ + L E E +V R ++ + ++ Sbjct: 73 YHVLE---TKNKIFMVLEYCPGGELFDYIISQDR---LSEEETRVVFRQILSAVAYVHSQ 126 Query: 130 GIVHRDIKPGNIMRVIGEDGQSVYKLTDFG--AARELEDDEQFVSLYGTEEYLHPDMYER 187 G HRD+KP N++ D KL DFG A + D G+ Y P++ + Sbjct: 127 GYAHRDLKPENLLF----DENHKLKLIDFGLCAKPKGNKDYHLQECCGSLAYAAPELIQ- 181 Query: 188 AVLRKDHQKKY-GATVDLWSIGVTFYHAATGSLPF 221 K Y G+ D+WS+G+ Y G LPF Sbjct: 182 -------GKSYLGSEADVWSMGILLYVLMCGFLPF 209 >3GUB-A nrPDB Length = 295 Score = 86.7 bits (213), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 68/213 (31%), Positives = 104/213 (48%), Gaps = 20/213 (9%) Query: 15 LGQGATANVFRGRHKKTGDLFA---IKVFNNISFLRPV---DVQMREFEVLKKLNHKNIV 68 LG G A V + R K TG +A IK S R V D++ RE +LK++ H N++ Sbjct: 19 LGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIE-REVSILKEIQHPNVI 77 Query: 69 KLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE 128 L + E T +LI E G L+ L E + L E E L+ ++ G+ +L Sbjct: 78 TLHEVYENKT--DVILIGELVAGGELFDFLAEKES---LTEEEATEFLKQILNGVYYLHS 132 Query: 129 NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERA 188 I H D+KP NIM + + K+ DFG A +++ +F +++GT E++ P++ Sbjct: 133 LQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAPEIVNYE 192 Query: 189 VLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 L G D+WSIGV Y +G+ PF Sbjct: 193 PL--------GLEADMWSIGVITYILLSGASPF 217 >3DAK-A nrPDB Length = 290 Score = 86.7 bits (213), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 71/259 (27%), Positives = 119/259 (45%), Gaps = 38/259 (14%) Query: 11 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKL 70 L +++G GATA V + AIK N +D ++E + + + +H NIV Sbjct: 14 LQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHHPNIVSY 73 Query: 71 ---FAIEEETTTRHKVLIMEFCPCGSLYTVL-------EEPSNAYGLPESEFLIVLRDVV 120 F +++E L+M+ GS+ ++ E S L ES +LR+V+ Sbjct: 74 YTSFVVKDELW-----LVMKLLSGGSVLDIIKHIVAKGEHKSGV--LDESTIATILREVL 126 Query: 121 GGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFV------SLY 174 G+ +L +NG +HRD+K GNI+ +GEDG ++ DFG + L + Sbjct: 127 EGLEYLHKNGQIHRDVKAGNIL--LGEDGS--VQIADFGVSAFLATGGDITRNKVRKTFV 182 Query: 175 GTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVM 234 GT ++ P++ E+ + Y D+WS G+T ATG+ P+ + P + V+ Sbjct: 183 GTPCWMAPEVMEQV-------RGYDFKADIWSFGITAIELATGAAPYHKYP-PMK---VL 231 Query: 235 YKIITGKPSGAISGVQKAE 253 + P +GVQ E Sbjct: 232 MLTLQNDPPSLETGVQDKE 250 >3KN6-A nrPDB Length = 325 Score = 86.3 bits (212), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 63/210 (30%), Positives = 106/210 (50%), Gaps = 20/210 (9%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKL-NHKNIVKLFAI 73 LG+G+ + + HKK+ FA+K+ IS + Q +E LK H NIVKL + Sbjct: 19 LGEGSFSICRKCVHKKSNQAFAVKI---ISKRMEANTQ-KEITALKLCEGHPNIVKLHEV 74 Query: 74 EEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVH 133 + H L+ME G L+ +++ + E+E ++R +V ++H+ + G+VH Sbjct: 75 FHDQL--HTFLVMELLNGGELFERIKKKKH---FSETEASYIMRKLVSAVSHMHDVGVVH 129 Query: 134 RDIKPGNIMRVIGEDGQSVYKLTDFGAAR-ELEDDEQFVSLYGTEEYLHPDMYERAVLRK 192 RD+KP N++ D + K+ DFG AR + D++ + T Y P++ Sbjct: 130 RDLKPENLLFTDENDNLEI-KIIDFGFARLKPPDNQPLKTPCFTLHYAAPELL------- 181 Query: 193 DHQKKYGATVDLWSIGVTFYHAATGSLPFR 222 +Q Y + DLWS+GV Y +G +PF+ Sbjct: 182 -NQNGYDESCDLWSLGVILYTMLSGQVPFQ 210 >4AGU-A nrPDB Length = 311 Score = 85.9 bits (211), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 70/218 (32%), Positives = 101/218 (46%), Gaps = 33/218 (15%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPV--DVQMREFEVLKKLNHKNIVKLFA 72 +G+G+ VF+ R++ TG + AIK F S PV + +RE +LK+L H N+V L Sbjct: 11 IGEGSYGVVFKCRNRDTGQIVAIKKFLE-SEDDPVIKKIALREIRMLKQLKHPNLVNLLE 69 Query: 73 IEEETTTRHKVLIMEFCPCGSLYTVLEEPSN-AYGLPESEFLIVLRDVVGGMNHLRENGI 131 + H L+ E+C +TVL E G+PE + + +N ++ Sbjct: 70 VFRRKRRLH--LVFEYCD----HTVLHELDRYQRGVPEHLVKSITWQTLQAVNFCHKHNC 123 Query: 132 VHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELE------DDEQFVSLYGTEEYLHPDMY 185 +HRD+KP NI+ SV KL DFG AR L DDE Y + E L D Sbjct: 124 IHRDVKPENILIT----KHSVIKLCDFGFARLLTGPSDYYDDEVATRWYRSPELLVGDT- 178 Query: 186 ERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRP 223 +YG VD+W+IG F +G +P P Sbjct: 179 -----------QYGPPVDVWAIGCVFAELLSG-VPLWP 204 >3I6U-A nrPDB Length = 419 Score = 85.5 bits (210), Expect = 7e-17, Method: Compositional matrix adjust. Identities = 68/240 (28%), Positives = 112/240 (46%), Gaps = 22/240 (9%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFL----RPVDVQMR---EFEVLKK 61 +++S LG GA V +KT AI++ + F R D + E E+LKK Sbjct: 137 YIMSKTLGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADPALNVETEIEILKK 196 Query: 62 LNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVG 121 LNH I+K I+ +++E G L+ ++ L E+ + ++ Sbjct: 197 LNHPCIIK---IKNFFDAEDYYIVLELMEGGELF---DKVVGNKRLKEATCKLYFYQMLL 250 Query: 122 GMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLH 181 + +L ENGI+HRD+KP N++ + ++ + K+TDFG ++ L + +L GT YL Sbjct: 251 AVQYLHENGIIHRDLKPENVL-LSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLA 309 Query: 182 PDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 241 P+ VL Y VD WS+GV + +G + PF R + +I +GK Sbjct: 310 PE-----VLVSVGTAGYNRAVDCWSLGVILFICLSG---YPPFSEHRTQVSLKDQITSGK 361 >5EZV-A nrPDB Length = 560 Score = 85.1 bits (209), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 60/216 (27%), Positives = 102/216 (47%), Gaps = 20/216 (9%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ---MREFEVLKKLNHK 65 ++L D LG G V G H+ TG A+K+ N +R +DV RE + LK H Sbjct: 30 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQK-IRSLDVVGKIKREIQNLKLFRHP 88 Query: 66 NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 125 +I+KL+ + +T ++ME+ G L+ + + + E E + + ++ +++ Sbjct: 89 HIIKLYQVI--STPTDFFMVMEYVSGGELFDYICKHGR---VEEMEARRLFQQILSAVDY 143 Query: 126 LRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMY 185 + +VHRD+KP N++ D K+ DFG + + D E + G+ Y P++ Sbjct: 144 CHRHMVVHRDLKPENVLL----DAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVI 199 Query: 186 ERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 + G VD+WS GV Y G+LPF Sbjct: 200 SGRLYA-------GPEVDIWSCGVILYALLCGTLPF 228 >2X4F-A nrPDB Length = 373 Score = 85.1 bits (209), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 61/222 (27%), Positives = 107/222 (48%), Gaps = 17/222 (7%) Query: 2 QSTSNHLWLLS--DILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVL 59 Q N + +S +ILG G V + TG A K+ +V+ E V+ Sbjct: 82 QGAVNSFYTVSKTEILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKEEVK-NEISVM 140 Query: 60 KKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDV 119 +L+H N+++L+ E + VL+ME+ G L+ + + S Y L E + ++ ++ + Sbjct: 141 NQLDHANLIQLYDAFE--SKNDIVLVMEYVDGGELFDRIIDES--YNLTELDTILFMKQI 196 Query: 120 VGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEY 179 G+ H+ + I+H D+KP NI+ + D + + K+ DFG AR + E+ +GT E+ Sbjct: 197 CEGIRHMHQMYILHLDLKPENIL-CVNRDAKQI-KIIDFGLARRYKPREKLKVNFGTPEF 254 Query: 180 LHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 L P++ + D+WS+GV Y +G PF Sbjct: 255 LAPEVVNYDFV--------SFPTDMWSVGVIAYMLLSGLSPF 288 >5D7A-A nrPDB Length = 308 Score = 84.7 bits (208), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 61/217 (28%), Positives = 112/217 (51%), Gaps = 16/217 (7%) Query: 11 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLN-HKNIVK 69 L +++G G V++GRH KTG L AIKV +++ +++ +E +LKK + H+NI Sbjct: 21 LVELVGNGTYGQVYKGRHVKTGQLAAIKVM-DVTGDEEEEIK-QEINMLKKYSHHRNIAT 78 Query: 70 LFAI----EEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 125 + L+MEFC GS+ +++ + L E + R+++ G++H Sbjct: 79 YYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKN-TKGNTLKEEWIAYICREILRGLSH 137 Query: 126 LRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD-EQFVSLYGTEEYLHPDM 184 L ++ ++HRDIK N++ + E+ + KL DFG + +L+ + + GT ++ P++ Sbjct: 138 LHQHKVIHRDIKGQNVL--LTENAE--VKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEV 193 Query: 185 YERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 ++ Y DLWS+G+T A G+ P Sbjct: 194 I---ACDENPDATYDFKSDLWSLGITAIEMAEGAPPL 227 >3Q5I-A nrPDB Length = 504 Score = 84.7 bits (208), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 71/241 (29%), Positives = 111/241 (46%), Gaps = 35/241 (14%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISF--LRPVDVQ----------MREFEVLKKL 62 LG GA V + K AIKV F R D E +LK L Sbjct: 44 LGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYSDDNKNIEKFHEEIYNEISLLKSL 103 Query: 63 NHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGG 122 +H NI+KLF + E+ ++ L+ EF G L+ E+ N + E + +++ ++ G Sbjct: 104 DHPNIIKLFDVFEDK--KYFYLVTEFYEGGELF---EQIINRHKFDECDAANIMKQILSG 158 Query: 123 MNHLRENGIVHRDIKPGNIMRVIGEDGQSVY--KLTDFGAARELEDDEQFVSLYGTEEYL 180 + +L ++ IVHRDIKP NI+ E+ S+ K+ DFG + D + GT Y+ Sbjct: 159 ICYLHKHNIVHRDIKPENILL---ENKNSLLNIKIVDFGLSSFFSKDYKLRDRLGTAYYI 215 Query: 181 HPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITG 240 P++ +KKY D+WS GV Y G PF G + +++++ K+ G Sbjct: 216 APEVL---------KKKYNEKCDVWSCGVIMYILLCGYPPF----GGQNDQDIIKKVEKG 262 Query: 241 K 241 K Sbjct: 263 K 263 >4U41-A nrPDB Length = 332 Score = 84.7 bits (208), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 66/217 (30%), Positives = 113/217 (52%), Gaps = 16/217 (7%) Query: 11 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLN-HKNIVK 69 L +++G G V++GRH KTG L AIKV +++ ++++ E +LKK + H+NI Sbjct: 28 LVEVVGNGTYGQVYKGRHVKTGQLAAIKVM-DVTEDEEEEIKL-EINMLKKYSHHRNIAT 85 Query: 70 LF-AIEEETTTRHK---VLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 125 + A +++ H L+MEFC GS+ T L + + L E + R+++ G+ H Sbjct: 86 YYGAFIKKSPPGHDDQLWLVMEFCGAGSI-TDLVKNTKGNTLKEDWIAYISREILRGLAH 144 Query: 126 LRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD-EQFVSLYGTEEYLHPDM 184 L + ++HRDIK N++ + E+ + KL DFG + +L+ + + GT ++ P Sbjct: 145 LHIHHVIHRDIKGQNVL--LTENAE--VKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP-- 198 Query: 185 YERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 E ++ Y DLWS G+T A G+ P Sbjct: 199 -EVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPL 234 >4CFF-A nrPDB Length = 571 Score = 84.7 bits (208), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 60/216 (27%), Positives = 102/216 (47%), Gaps = 20/216 (9%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ---MREFEVLKKLNHK 65 ++L D LG G V G H+ TG A+K+ N +R +DV RE + LK H Sbjct: 35 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQK-IRSLDVVGKIKREIQNLKLFRHP 93 Query: 66 NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 125 +I+KL+ + +T ++ME+ G L+ + + + E E + + ++ +++ Sbjct: 94 HIIKLYQVI--STPTDFFMVMEYVSGGELFDYICKHGR---VEEMEARRLFQQILSAVDY 148 Query: 126 LRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMY 185 + +VHRD+KP N++ D K+ DFG + + D E + G+ Y P++ Sbjct: 149 CHRHMVVHRDLKPENVLL----DAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVI 204 Query: 186 ERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 + G VD+WS GV Y G+LPF Sbjct: 205 SGRLYA-------GPEVDIWSCGVILYALLCGTLPF 233 >2V7O-A nrPDB Length = 336 Score = 84.0 bits (206), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 70/211 (33%), Positives = 103/211 (48%), Gaps = 20/211 (9%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQM--REFEVLKKLNHKNIVKLF- 71 LG+GA + V R K +A K+ N L D Q RE + + L H NIV+L Sbjct: 39 LGKGAFSVVRRCVKKTPTQEYAAKIINTKK-LSARDHQKLEREARICRLLKHPNIVRLHD 97 Query: 72 AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGI 131 +I EE L+ + G L+ E+ E++ + ++ +NH+ ++ I Sbjct: 98 SISEEG---FHYLVFDLVTGGELF---EDIVAREYYSEADASHCIHQILESVNHIHQHDI 151 Query: 132 VHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQ-FVSLYGTEEYLHPDMYERAVL 190 VHRD+KP N++ G +V KL DFG A E++ ++Q + GT YL P+ VL Sbjct: 152 VHRDLKPENLLLASKCKGAAV-KLADFGLAIEVQGEQQAWFGFAGTPGYLSPE-----VL 205 Query: 191 RKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 RKD YG VD+W+ GV Y G PF Sbjct: 206 RKD---PYGKPVDIWACGVILYILLVGYPPF 233 >2BRG-A nrPDB Length = 297 Score = 84.0 bits (206), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 62/219 (28%), Positives = 103/219 (47%), Gaps = 25/219 (11%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ---MREFEVLKKLNHK 65 W L LG+GA V ++ T + A+K+ + R VD +E + K LNH+ Sbjct: 9 WDLVQTLGEGAYGEVQLAVNRVTEEAVAVKI---VDMKRAVDCPENIKKEICINKMLNHE 65 Query: 66 NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 125 N+VK + E ++ L +E+C G L+ +E G+PE + ++ G+ + Sbjct: 66 NVVKFYGHRREGNIQY--LFLEYCSGGELFDRIEP---DIGMPEPDAQRFFHQLMAGVVY 120 Query: 126 LRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAA---RELEDDEQFVSLYGTEEYLHP 182 L GI HRDIKP N++ D + K++DFG A R + + GT Y+ P Sbjct: 121 LHGIGITHRDIKPENLLL----DERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAP 176 Query: 183 DMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 ++ +R ++ + VD+WS G+ G LP+ Sbjct: 177 ELLKR-------REFHAEPVDVWSCGIVLTAMLAGELPW 208 >4D28-A nrPDB Length = 446 Score = 84.0 bits (206), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 65/217 (29%), Positives = 100/217 (46%), Gaps = 21/217 (9%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFL--RPVDVQMREFEVLKKLNHKNIVKLFA 72 +G+G A V R+ TGD AIK+ + L R VD RE ++K + H NIV+L+ Sbjct: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLY- 75 Query: 73 IEEETTTRHKV-LIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGI 131 E ++ K+ +++EF G L+ + L E E + +V + H G+ Sbjct: 76 --EVLASKSKIYIVLEFVTGGELFDRIVHKGR---LKEDESRKYFQQLVDAVAHCHSKGV 130 Query: 132 VHRDIKPGNIMRVIGEDGQSVYKLTDFG-AARELEDDEQFVSLYGTEEYLHPDMYERAVL 190 HRD+KP N++ D K++DFG +A E E GT Y+ P++ Sbjct: 131 YHRDLKPENLLL----DTNGNLKVSDFGLSALPQEGVELLNDTCGTPNYVAPEVL----- 181 Query: 191 RKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGP 227 Q G+ D+WS GV + G LPF + P Sbjct: 182 --SGQGYDGSAADIWSCGVILFVILAGYLPFSETDLP 216 >5DBX-A nrPDB Length = 328 Score = 84.0 bits (206), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 62/229 (27%), Positives = 109/229 (47%), Gaps = 32/229 (13%) Query: 11 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKL 70 L +++G GATA V K + AIK N +D ++E + + + +H N+V Sbjct: 15 LQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQCSHPNVVTY 74 Query: 71 ---FAIEEETTTRHKVLIMEFCPCGSLYTVLE------EPSNAYGLPESEFLIVLRDVVG 121 F +++E L+M+ GS+ +++ E N L E+ +L++V+ Sbjct: 75 YTSFVVKDELW-----LVMKLLSGGSMLDIIKYIVNRGEHKNGV-LEEAIIATILKEVLE 128 Query: 122 GMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFV------SLYG 175 G+++L NG +HRD+K GNI+ +GEDG ++ DFG + L G Sbjct: 129 GLDYLHRNGQIHRDLKAGNIL--LGEDGS--VQIADFGVSAFLATGGDVTRNKVRKDFVG 184 Query: 176 TEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPF 224 T ++ P++ E+ + Y D+WS G+T ATG+ P+ + Sbjct: 185 TPCWMAPEVMEQV-------RGYDFKADMWSFGITAIELATGAAPYHKY 226 >3COM-A nrPDB Length = 314 Score = 83.6 bits (205), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 57/208 (27%), Positives = 108/208 (51%), Gaps = 20/208 (9%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 74 LG+G+ +V++ HK+TG + AIK S L+ + ++E ++++ + ++VK + Sbjct: 37 LGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEI---IKEISIMQQCDSPHVVKYYGSY 93 Query: 75 EETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHR 134 + T ++ME+C GS+ ++ + L E E +L+ + G+ +L +HR Sbjct: 94 FKNTDLW--IVMEYCGAGSVSDIIRLRNKT--LTEDEIATILQSTLKGLEYLHFMRKIHR 149 Query: 135 DIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD-EQFVSLYGTEEYLHPDMYERAVLRKD 193 DIK GNI+ + +G + KL DFG A +L D + ++ GT ++ P++ + Sbjct: 150 DIKAGNIL--LNTEGHA--KLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQ------- 198 Query: 194 HQKKYGATVDLWSIGVTFYHAATGSLPF 221 + Y D+WS+G+T A G P+ Sbjct: 199 -EIGYNCVADIWSLGITAIEMAEGKPPY 225 >2YZA-A nrPDB Length = 276 Score = 83.6 bits (205), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 60/216 (27%), Positives = 101/216 (46%), Gaps = 20/216 (9%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ---MREFEVLKKLNHK 65 ++L D LG G V G H+ TG A+K+ N +R +DV RE + LK H Sbjct: 13 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQK-IRSLDVVGKIKREIQNLKLFRHP 71 Query: 66 NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 125 +I+KL+ + +T ++ME+ G L+ + + + E E + + ++ +++ Sbjct: 72 HIIKLYQVI--STPTDFFMVMEYVSGGELFDYICKHGR---VEEMEARRLFQQILSAVDY 126 Query: 126 LRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMY 185 + +VHRD+KP N++ D K+ DFG + + D E G+ Y P++ Sbjct: 127 CHRHMVVHRDLKPENVLL----DAHMNAKIADFGLSNMMSDGEFLRDSCGSPNYAAPEVI 182 Query: 186 ERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 + G VD+WS GV Y G+LPF Sbjct: 183 SGRLYA-------GPEVDIWSCGVILYALLCGTLPF 211 >4RLP-A nrPDB Length = 288 Score = 83.6 bits (205), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 71/230 (30%), Positives = 104/230 (45%), Gaps = 27/230 (11%) Query: 11 LSDILGQGATANVFRGRH---KKTGDLFAIKVFNNISFLRPVDVQMR---EFEVLKKLNH 64 L +LG+G VF+ R TG +FA+KV +R E +L+++ H Sbjct: 9 LLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKH 68 Query: 65 KNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 124 IV L I T LI+E+ G L+ LE E L ++ + Sbjct: 69 PFIVDL--IYAFQTGGKLYLILEYLSGGELFMQLEREGI---FMEDTACFYLAEISMALG 123 Query: 125 HLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARE-LEDDEQFVSLYGTEEYLHPD 183 HL + GI++RD+KP NIM + Q KLTDFG +E + D + GT EY+ P+ Sbjct: 124 HLHQKGIIYRDLKPENIML----NHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPE 179 Query: 184 MYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEV 233 + ++R H + VD WS+G Y TG+ PF G R K + Sbjct: 180 I----LMRSGHNR----AVDWWSLGALMYDMLTGA---PPFTGENRKKTI 218 >3SOA-A nrPDB Length = 444 Score = 83.6 bits (205), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 71/211 (33%), Positives = 102/211 (48%), Gaps = 20/211 (9%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQM--REFEVLKKLNHKNIVKLF- 71 LG+GA + V R G +A + N L D Q RE + + L H NIV+L Sbjct: 19 LGKGAFSVVRRCVKVLAGQEYAAMIINTKK-LSARDHQKLEREARICRLLKHPNIVRLHD 77 Query: 72 AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGI 131 +I EE H LI + G L+ E+ E++ ++ ++ + H + G+ Sbjct: 78 SISEEG---HHYLIFDLVTGGELF---EDIVAREYYSEADASHCIQQILEAVLHCHQMGV 131 Query: 132 VHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQ-FVSLYGTEEYLHPDMYERAVL 190 VHR++KP N++ G +V KL DFG A E+E ++Q + GT YL P+ VL Sbjct: 132 VHRNLKPENLLLASKLKGAAV-KLADFGLAIEVEGEQQAWFGFAGTPGYLSPE-----VL 185 Query: 191 RKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 RKD YG VDLW+ GV Y G PF Sbjct: 186 RKD---PYGKPVDLWACGVILYILLVGYPPF 213 >3BHH-A nrPDB Length = 295 Score = 83.6 bits (205), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 73/223 (32%), Positives = 108/223 (48%), Gaps = 21/223 (9%) Query: 3 STSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQM--REFEVLK 60 S ++ L DI G+GA + V R TG +A K+ N L D Q RE + + Sbjct: 1 SMTDEYQLYEDI-GKGAFSVVRRCVKLCTGHEYAAKIINTKK-LSARDHQKLEREARICR 58 Query: 61 KLNHKNIVKLF-AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDV 119 L H NIV+L +I EE L+ + G L+ E+ E++ ++ + Sbjct: 59 LLKHSNIVRLHDSISEEG---FHYLVFDLVTGGELF---EDIVAREYYSEADASHCIQQI 112 Query: 120 VGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQ-FVSLYGTEE 178 + + H + G+VHRD+KP N++ G +V KL DFG A E++ D+Q + GT Sbjct: 113 LEAVLHCHQMGVVHRDLKPENLLLASKCKGAAV-KLADFGLAIEVQGDQQAWFGFAGTPG 171 Query: 179 YLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 YL P+ VLRK+ YG VD+W+ GV Y G PF Sbjct: 172 YLSPE-----VLRKE---AYGKPVDIWACGVILYILLVGYPPF 206 >4CZT-A nrPDB Length = 464 Score = 83.2 bits (204), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 60/217 (27%), Positives = 103/217 (47%), Gaps = 23/217 (10%) Query: 11 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQM--REFEVLKKLNHKNIV 68 L LG+G A V R+ + GD AIKV + L+ + RE +K + H N++ Sbjct: 15 LGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVI 74 Query: 69 KLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE 128 ++F + T + ++EF G L+ ++ S+ L E E + ++ +++ Sbjct: 75 RMFEVMASKTKIY--FVLEFVTGGELF---DKISSNGRLKEDEARKYFQQLINAVDYCHS 129 Query: 129 NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAA---RELEDDEQFVSLYGTEEYLHPDMY 185 G+ HRD+KP N++ D K++DFG + +++ +D + GT Y+ P++ Sbjct: 130 RGVYHRDLKPENLLL----DANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVI 185 Query: 186 ERAVLRKDHQKKY-GATVDLWSIGVTFYHAATGSLPF 221 + K Y GA DLWS GV + G LPF Sbjct: 186 --------NNKGYDGAKADLWSCGVILFVLMAGYLPF 214 >3MA6-A nrPDB Length = 298 Score = 83.2 bits (204), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 58/210 (27%), Positives = 103/210 (49%), Gaps = 17/210 (8%) Query: 14 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHKNIVKLF 71 +LG+G+ V + K TG A+KV + + D + +RE ++LK+L+H NI+KL+ Sbjct: 39 VLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDHPNIMKLY 98 Query: 72 AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGI 131 E+ + L+ E G L+ +E + E + ++R V+ G+ ++ +N I Sbjct: 99 EFFEDKGYFY--LVGEVYTGGELF---DEIISRKRFSEVDAARIIRQVLSGITYMHKNKI 153 Query: 132 VHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLR 191 VHRD+KP N++ + + + ++ DFG + E ++ GT Y+ P++ Sbjct: 154 VHRDLKPENLL-LESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVLHGT--- 209 Query: 192 KDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 Y D+WS GV Y +G PF Sbjct: 210 ------YDEKCDVWSTGVILYILLSGCPPF 233 >4L42-A nrPDB Length = 346 Score = 82.8 bits (203), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 70/227 (30%), Positives = 103/227 (45%), Gaps = 27/227 (11%) Query: 14 ILGQGATANVFRGRH---KKTGDLFAIKVFNNISFLRPVDVQMR---EFEVLKKLNHKNI 67 +LG+G VF+ R TG +FA+KV +R E +L+++ H I Sbjct: 25 VLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFI 84 Query: 68 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 127 V L I T LI+E+ G L+ LE E L ++ + HL Sbjct: 85 VDL--IYAFQTGGKLYLILEYLSGGELFMQLEREGI---FMEDTACFYLAEISMALGHLH 139 Query: 128 ENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARE-LEDDEQFVSLYGTEEYLHPDMYE 186 + GI++RD+KP NIM + Q KLTDFG +E + D + GT EY+ P++ Sbjct: 140 QKGIIYRDLKPENIML----NHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEI-- 193 Query: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEV 233 ++R H + VD WS+G Y TG+ PF G R K + Sbjct: 194 --LMRSGHNR----AVDWWSLGALMYDMLTGA---PPFTGENRKKTI 231 >4FG9-A nrPDB Length = 320 Score = 82.4 bits (202), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 67/209 (32%), Positives = 94/209 (44%), Gaps = 14/209 (6%) Query: 13 DILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFA 72 D+LG GA + V K+T L AIK + E VL K+ H NIV L Sbjct: 24 DVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMENEIAVLHKIKHPNIVALDD 83 Query: 73 IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIV 132 I E + H LIM+ G L+ + E Y ++ LI V+ + +L + GIV Sbjct: 84 IYE--SGGHLYLIMQLVSGGELFDRIVE-KGFYTERDASRLIF--QVLDAVKYLHDLGIV 138 Query: 133 HRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRK 192 HRD+KP N++ D S ++DFG ++ + + GT Y+ P++ Sbjct: 139 HRDLKPENLL-YYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVLA------ 191 Query: 193 DHQKKYGATVDLWSIGVTFYHAATGSLPF 221 QK Y VD WSIGV Y G PF Sbjct: 192 --QKPYSKAVDCWSIGVIAYILLCGYPPF 218 >5JN2-A nrPDB Length = 525 Score = 82.0 bits (201), Expect = 9e-16, Method: Compositional matrix adjust. Identities = 58/210 (27%), Positives = 103/210 (49%), Gaps = 17/210 (8%) Query: 14 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHKNIVKLF 71 +LG+G+ V + K TG A+KV + + D + +RE ++LK+L+H NI+KL+ Sbjct: 74 VLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDHPNIMKLY 133 Query: 72 AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGI 131 E+ + L+ E G L+ +E + E + ++R V+ G+ ++ +N I Sbjct: 134 EFFEDKG--YFYLVGEVYTGGELF---DEIISRKRFSEVDAARIIRQVLSGITYMHKNKI 188 Query: 132 VHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLR 191 VHRD+KP N++ + + + ++ DFG + E ++ GT Y+ P++ Sbjct: 189 VHRDLKPENLL-LESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVL------ 241 Query: 192 KDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 Y D+WS GV Y +G PF Sbjct: 242 ---HGTYDEKCDVWSTGVILYILLSGCPPF 268 >4WB7-A nrPDB Length = 405 Score = 81.6 bits (200), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 64/233 (27%), Positives = 119/233 (51%), Gaps = 33/233 (14%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNN--ISFLRPVDVQMREFEVLKKLNHKNIVKL-F 71 LG G+ V +HK+TG+ +A+K+ + + L+ ++ + E +L+ +N +VKL F Sbjct: 104 LGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEF 163 Query: 72 AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGI 131 + ++ + ++ME+ P G +++ L + P + F +V +L + Sbjct: 164 SFKDNSNL---YMVMEYVPGGEMFSHLRRIGR-FSEPHARFYAA--QIVLTFEYLHSLDL 217 Query: 132 VHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLR 191 ++RD+KP N++ D Q ++TDFG A+ ++ + +L GT EYL P++ +L Sbjct: 218 IYRDLKPENLLI----DQQGYIQVTDFGFAKRVKG--RTWTLCGTPEYLAPEI----ILS 267 Query: 192 KDHQKKYGATVDLWSIGVTFYHAATGSLPF---RPFEGPRRNKEVMYKIITGK 241 K + K VD W++GV Y A G PF +P ++ KI++GK Sbjct: 268 KGYNK----AVDWWALGVLIYEMAAGYPPFFADQPI-------QIYEKIVSGK 309 >5JZN-A nrPDB Length = 280 Score = 81.6 bits (200), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 66/228 (28%), Positives = 105/228 (46%), Gaps = 19/228 (8%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 74 +G G A V + T +A+K+ + E +L+++ H NIV L IE Sbjct: 27 IGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHMIQNEVSILRRVKHPNIVLL--IE 84 Query: 75 EETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHR 134 E L+ME G L+ + +N Y E + +L ++ + +L IVHR Sbjct: 85 EMDVPTELYLVMELVKGGDLFDAITS-TNKY--TERDASGMLYNLASAIKYLHSLNIVHR 141 Query: 135 DIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDH 194 DIKP N++ +DG KL DFG A + D ++ GT Y+ P++ Sbjct: 142 DIKPENLLVYEHQDGSKSLKLGDFGLATIV--DGPLYTVCGTPTYVAPEIIA-------- 191 Query: 195 QKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMY-KIITGK 241 + YG VD+W+ GV Y G F PF G ++EV++ +I+ G+ Sbjct: 192 ETGYGLKVDIWAAGVITYILLCG---FPPFRGSGDDQEVLFDQILMGQ 236 >6E9W-A nrPDB Length = 443 Score = 81.3 bits (199), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 58/214 (27%), Positives = 102/214 (47%), Gaps = 22/214 (10%) Query: 14 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQM--REFEVLKKLNHKNIVKLF 71 ++G+GA V RHK T ++A+K+ + ++ D E +++ N +V+LF Sbjct: 109 VIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLF 168 Query: 72 -AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 130 A +++ R+ ++ME+ P G L ++ Y +PE +VV ++ + G Sbjct: 169 YAFQDD---RYLYMVMEYMPGGDLVNLMSN----YDVPEKWARFYTAEVVLALDAIHSMG 221 Query: 131 IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFV---SLYGTEEYLHPDMYER 187 +HRD+KP N++ D KL DFG ++ + E V + GT +Y+ P++ + Sbjct: 222 FIHRDVKPDNMLL----DKSGHLKLADFGTCMKM-NKEGMVRCDTAVGTPDYISPEVLK- 275 Query: 188 AVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 + YG D WS+GV Y G PF Sbjct: 276 ---SQGGDGYYGRECDWWSVGVFLYEMLVGDTPF 306 >2XNP-A nrPDB Length = 279 Score = 81.3 bits (199), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 67/236 (28%), Positives = 105/236 (44%), Gaps = 26/236 (11%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQM--REFEVLKKLNHKNIVKLFA 72 +G G+ + R K G + K + S + + QM E +L++L H NIV+ + Sbjct: 14 IGTGSYGRCQKIRRKSDGKILVWKELDYGS-MTEAEKQMLVSEVNLLRELKHPNIVRYYD 72 Query: 73 IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLI-VLRDVVGGMN--HLREN 129 + T ++ME+C G L +V+ + + + EF++ V+ + + H R + Sbjct: 73 RIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSD 132 Query: 130 G---IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLY-GTEEYLHPDMY 185 G ++HRD+KP N+ DG+ KL DFG AR L D F + GT Y+ P+ Sbjct: 133 GGHTVLHRDLKPANVFL----DGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSPEQM 188 Query: 186 ERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 241 R Y D+WS+G Y PF F KE+ KI GK Sbjct: 189 NRM--------SYNEKSDIWSLGCLLYELCALMPPFTAFS----QKELAGKIREGK 232 >6ED6-A nrPDB Length = 415 Score = 80.9 bits (198), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 57/214 (26%), Positives = 103/214 (48%), Gaps = 22/214 (10%) Query: 14 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQM--REFEVLKKLNHKNIVKLF 71 ++G+GA V RHK + ++A+K+ + ++ D E +++ N +V+LF Sbjct: 95 VIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLF 154 Query: 72 -AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 130 A +++ R+ ++ME+ P G L ++ Y +PE +VV ++ + G Sbjct: 155 YAFQDD---RYLYMVMEYMPGGDLVNLMSN----YDVPEKWAKFYTAEVVLALDAIHSMG 207 Query: 131 IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFV---SLYGTEEYLHPDMYER 187 ++HRD+KP N++ D KL DFG ++ D+ V + GT +Y+ P++ + Sbjct: 208 LIHRDVKPDNMLL----DKHGHLKLADFGTCMKM-DETGMVHCDTAVGTPDYISPEVLK- 261 Query: 188 AVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 + YG D WS+GV Y G PF Sbjct: 262 ---SQGGDGFYGRECDWWSVGVFLYEMLVGDTPF 292 >4JXF-A nrPDB Length = 266 Score = 80.9 bits (198), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 58/214 (27%), Positives = 106/214 (49%), Gaps = 19/214 (8%) Query: 11 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHKNIV 68 + ++LG+G+ A V+R TG AIK+ + + + VQ E ++ +L H +I+ Sbjct: 11 VGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSIL 70 Query: 69 KLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE 128 +L+ E++ + L++E C G + L+ + E+E + ++ GM +L Sbjct: 71 ELYNYFEDSN--YVYLVLEMCHNGEMNRYLKNRVKPFS--ENEARHFMHQIITGMLYLHS 126 Query: 129 NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELE-DDEQFVSLYGTEEYLHPDMYER 187 +GI+HRD+ N++ + K+ DFG A +L+ E+ +L GT Y+ P++ R Sbjct: 127 HGILHRDLTLSNLLLTRNMN----IKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATR 182 Query: 188 AVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 + +G D+WS+G FY G PF Sbjct: 183 SA--------HGLESDVWSLGCMFYTLLIGRPPF 208 >3TKU-A nrPDB Length = 433 Score = 80.1 bits (196), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 61/213 (28%), Positives = 103/213 (48%), Gaps = 17/213 (7%) Query: 14 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQM--REFEVLKKLNHKNIVKL- 70 ++G+GA V + K T ++A+K+ N L+ + E +VL + + I L Sbjct: 97 VIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDCQWITALH 156 Query: 71 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 130 +A ++E H L+M++ G L T+L + + LPE + ++V ++ + + Sbjct: 157 YAFQDEN---HLYLVMDYYVGGDLLTLLSKFEDK--LPEDMARFYIGEMVLAIDSIHQLH 211 Query: 131 IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVS--LYGTEEYLHPDMYERA 188 VHRDIKP N++ D +L DFG+ ++ DD S GT +Y+ P++ + Sbjct: 212 YVHRDIKPDNVLL----DVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAM 267 Query: 189 VLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 +D KYG D WS+GV Y G PF Sbjct: 268 ---EDGMGKYGPECDWWSLGVCMYEMLYGETPF 297 >4LG4-A nrPDB Length = 299 Score = 80.1 bits (196), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 56/208 (26%), Positives = 107/208 (51%), Gaps = 20/208 (9%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 74 LG+G+ +VF+ HK++G + AIK S L+ + ++E ++++ + +VK + Sbjct: 19 LGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEI---IKEISIMQQCDSPYVVKYYGSY 75 Query: 75 EETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHR 134 + T ++ME+C GS+ ++ + L E E +L+ + G+ +L +HR Sbjct: 76 FKNTDLW--IVMEYCGAGSVSDIIRLRNKT--LIEDEIATILKSTLKGLEYLHFMRKIHR 131 Query: 135 DIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD-EQFVSLYGTEEYLHPDMYERAVLRKD 193 +IK GNI+ + +G + KL DFG A +L D + ++ GT ++ P++ + Sbjct: 132 NIKAGNIL--LNTEGHA--KLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQ------- 180 Query: 194 HQKKYGATVDLWSIGVTFYHAATGSLPF 221 + Y D+WS+G+T A G P+ Sbjct: 181 -EIGYNCVADIWSLGITSIEMAEGKPPY 207 >4BGQ-A nrPDB Length = 304 Score = 80.1 bits (196), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 69/234 (29%), Positives = 113/234 (48%), Gaps = 23/234 (9%) Query: 14 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPV-DVQMREFEVLKKLNHKNIVKLFA 72 ++G+GA V + RHK+T ++ AIK F + V + +RE ++L+ L +NIV+L Sbjct: 19 VVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVEL-- 76 Query: 73 IEEETTTRHKV-LIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGI 131 +E R K+ L+ E+ ++ +LEE N G+P + + ++ ++ +N I Sbjct: 77 -KEAFRRRGKLYLVFEYVE-KNMLELLEEMPN--GVPPEKVKSYIYQLIKAIHWCHKNDI 132 Query: 132 VHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELE--DDEQFVSLYGTEEYLHPDMYERAV 189 VHRDIKP N++ V KL DFG AR L ++ + T Y P++ A Sbjct: 133 VHRDIKPENLLI----SHNDVLKLCDFGFARNLSEGNNANYDEEVATRWYRSPELLLGA- 187 Query: 190 LRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS 243 YG +VD+WS+G + G P P E + K++ PS Sbjct: 188 -------PYGKSVDMWSVGCILGELSDGQ-PLFPGESEIDQLFTIQKVLGPLPS 233 >6AO5-A nrPDB Length = 362 Score = 80.1 bits (196), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 56/208 (26%), Positives = 107/208 (51%), Gaps = 20/208 (9%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 74 LG+G+ +VF+ HK++G + AIK S L+ + ++E ++++ + +VK + Sbjct: 18 LGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEI---IKEISIMQQCDSPYVVKYYGSY 74 Query: 75 EETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHR 134 + T ++ME+C GS+ ++ + L E E +L+ + G+ +L +HR Sbjct: 75 FKNTDLW--IVMEYCGAGSVSDIIRLRNKT--LIEDEIATILKSTLKGLEYLHFMRKIHR 130 Query: 135 DIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD-EQFVSLYGTEEYLHPDMYERAVLRKD 193 +IK GNI+ + +G + KL DFG A +L D + ++ GT ++ P++ + Sbjct: 131 NIKAGNIL--LNTEGHA--KLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQ------- 179 Query: 194 HQKKYGATVDLWSIGVTFYHAATGSLPF 221 + Y D+WS+G+T A G P+ Sbjct: 180 -EIGYNCVADIWSLGITSIEMAEGKPPY 206 >3HDN-A nrPDB Length = 373 Score = 79.3 bits (194), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 67/234 (28%), Positives = 105/234 (44%), Gaps = 28/234 (11%) Query: 14 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVL-KKLNHKNIVKL 70 ++G+G+ V RHK +A+KV + L+ + + M E VL K + H +V L Sbjct: 45 VIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGL 104 Query: 71 -FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN 129 F+ + T ++++ G L+ L+ + P + F ++ + +L Sbjct: 105 HFSFQ---TADKLYFVLDYINGGELFYHLQR-ERCFLEPRARFYAA--EIASALGYLHSL 158 Query: 130 GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARE-LEDDEQFVSLYGTEEYLHPDMYERA 188 IV+RD+KP NI+ D Q LTDFG +E +E + + GT EYL P++ Sbjct: 159 NIVYRDLKPENILL----DSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVL--- 211 Query: 189 VLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKP 242 H++ Y TVD W +G Y G PF RN MY I KP Sbjct: 212 -----HKQPYDRTVDWWCLGAVLYEMLYGLPPFY-----SRNTAEMYDNILNKP 255 >3TXO-A nrPDB Length = 353 Score = 79.0 bits (193), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 60/212 (28%), Positives = 101/212 (47%), Gaps = 21/212 (9%) Query: 14 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLK-KLNHKNIVKL 70 +LG+G+ V R K+TGDL+A+KV L+ DV+ M E +L NH + +L Sbjct: 30 VLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQL 89 Query: 71 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 130 F + T +MEF G L +++ S + + F +++ + L + G Sbjct: 90 FCCFQ--TPDRLFFVMEFVNGGDLMFHIQK-SRRFDEARARFYAA--EIISALMFLHDKG 144 Query: 131 IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARE-LEDDEQFVSLYGTEEYLHPDMYERAV 189 I++RD+K N++ D + KL DFG +E + + + GT +Y+ P++ + + Sbjct: 145 IIYRDLKLDNVLL----DHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEML 200 Query: 190 LRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 YG VD W++GV Y G PF Sbjct: 201 --------YGPAVDWWAMGVLLYEMLCGHAPF 224 >2WTK-C nrPDB Length = 305 Score = 79.0 bits (193), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 59/205 (28%), Positives = 97/205 (47%), Gaps = 35/205 (17%) Query: 54 REFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFL 113 +E ++L++L HKN+++L + + ++ME+C CG + +L+ +PE F Sbjct: 55 KEIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCG-MQEMLDS------VPEKRFP 107 Query: 114 IV-----LRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELED-- 166 + ++ G+ +L GIVH+DIKPGN++ G K++ G A L Sbjct: 108 VCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTG----GTLKISALGVAEALHPFA 163 Query: 167 -DEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFE 225 D+ + G+ + P+ + G VD+WS GVT Y+ TG PFE Sbjct: 164 ADDTCRTSQGSPAFQPPE------IANGLDTFSGFKVDIWSAGVTLYNITTG---LYPFE 214 Query: 226 GPRRNKEVMYKII--TGKPSGAISG 248 G + +YK+ GK S AI G Sbjct: 215 G-----DNIYKLFENIGKGSYAIPG 234 >5N23-A nrPDB Length = 352 Score = 78.6 bits (192), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 62/233 (26%), Positives = 117/233 (50%), Gaps = 32/233 (13%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNN--ISFLRPVDVQMREFEVLKKLNHKNIVKL-F 71 LG G+ V +HK+TG+ +A+K+ + + L+ ++ + E + + +N +VKL F Sbjct: 50 LGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRIQQAVNFPFLVKLEF 109 Query: 72 AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGI 131 + ++ + +++E+ P G +++ L + P + F +V +L + Sbjct: 110 SFKDNSNL---YMVLEYAPGGEMFSHLRRIGR-FSEPHARFYAA--QIVLTFEYLHSLDL 163 Query: 132 VHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLR 191 ++RD+KP N++ D Q K+ DFG A+ ++ + +L GT EYL P++ +L Sbjct: 164 IYRDLKPENLLI----DQQGYIKVADFGFAKRVKGRTPW-TLCGTPEYLAPEI----ILS 214 Query: 192 KDHQKKYGATVDLWSIGVTFYHAATGSLPF---RPFEGPRRNKEVMYKIITGK 241 K + K VD W++GV Y A G PF +P ++ KI++GK Sbjct: 215 KGYNK----AVDWWALGVLIYEMAAGYPPFFADQPI-------QIYEKIVSGK 256 >6FD3-A nrPDB Length = 300 Score = 78.6 bits (192), Expect = 9e-15, Method: Compositional matrix adjust. Identities = 67/230 (29%), Positives = 108/230 (46%), Gaps = 25/230 (10%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 74 +GQGA+ V+ TG AIK N + ++ + E V+++ + NIV ++ Sbjct: 30 IGQGASGTVYTALDIATGQEVAIKQMN-LQQQPKKELIINEILVMRENKNPNIVNY--LD 86 Query: 75 EETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHR 134 ++ME+ GSL V+ E + E + V R+ + ++ L N ++HR Sbjct: 87 SYLVGDELWVVMEYLAGGSLTDVVTETC----MDEGQIAAVCRECLQALDFLHSNQVIHR 142 Query: 135 DIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVS-LYGTEEYLHPDMYERAVLRKD 193 DIK NI+ +G DG KLTDFG ++ ++ S + GT ++ P++ R Sbjct: 143 DIKSDNIL--LGMDGS--VKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTR------ 192 Query: 194 HQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIIT-GKP 242 K YG VD+WS+G+ G P+ E P R +Y I T G P Sbjct: 193 --KAYGPKVDIWSLGIMAIEMVEGEPPYL-NENPLR---ALYLIATNGTP 236 >1VZO-A nrPDB Length = 355 Score = 78.6 bits (192), Expect = 9e-15, Method: Compositional matrix adjust. Identities = 72/242 (29%), Positives = 112/242 (46%), Gaps = 26/242 (10%) Query: 11 LSDILGQGATANVFRGRH---KKTGDLFAIKVFNNISFLRPVDVQ---MREFEVLKKLNH 64 L +LG GA VF R TG L+A+KV + ++ E +VL+ + Sbjct: 58 LLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQ 117 Query: 65 KN-IVKL-FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGG 122 +V L +A + ET LI+++ G L+T L + E E I + ++V Sbjct: 118 SPFLVTLHYAFQTETKLH---LILDYINGGELFTHLSQRER---FTEHEVQIYVGEIVLA 171 Query: 123 MNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDE--QFVSLYGTEEYL 180 + HL + GI++RDIK NI+ + +G V LTDFG ++E DE + GT EY+ Sbjct: 172 LEHLHKLGIIYRDIKLENIL--LDSNGHVV--LTDFGLSKEFVADETERAYDFCGTIEYM 227 Query: 181 HPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITG 240 PD+ + + VD WS+GV Y TG+ PF E+ +I+ Sbjct: 228 APDIV------RGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKS 281 Query: 241 KP 242 +P Sbjct: 282 EP 283 >5FET-A nrPDB Length = 847 Score = 78.6 bits (192), Expect = 9e-15, Method: Compositional matrix adjust. Identities = 66/234 (28%), Positives = 113/234 (48%), Gaps = 31/234 (13%) Query: 14 ILGQGATANVFRGRHKKTGDLFAIKVFNN---ISFLRPVDVQMREFEVLKKLNHKNIVKL 70 I+G+G V HK T +A+K + IS + ++++ E E+ + +H I++L Sbjct: 540 IIGRGTFGTVKLVHHKPTQIRYALKCVSKRSIISLNQQNNIKL-EREITAENDHPFIIRL 598 Query: 71 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGL---PESEFLIVLRDVVGGMNHLR 127 +++ + + E G LY + + GL P+++F L ++ + +L Sbjct: 599 VRTFKDSNCFY--FLTELVTGGELYDAIRK----LGLLSKPQAQFY--LGSIILAIEYLH 650 Query: 128 ENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYER 187 E IV+RD+KP NI+ D Q KL DFG A++++ + +L GT Y+ P++ Sbjct: 651 ERNIVYRDLKPENILL----DKQGYVKLIDFGCAKKIQG--RAYTLVGTPHYMAPEVI-- 702 Query: 188 AVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 241 K YG TVD+W++GV Y G LPF E+ I+TG+ Sbjct: 703 ------LGKGYGCTVDIWALGVCLYEFICGPLPFG--NDQEDQLEIFRDILTGQ 748 >4QMW-A nrPDB Length = 310 Score = 78.6 bits (192), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 56/207 (27%), Positives = 102/207 (49%), Gaps = 19/207 (9%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 74 +G+G+ VF+G +T + AIK+ + ++ +E VL + + + K + Sbjct: 37 IGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYGSY 96 Query: 75 EETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHR 134 + T +IME+ GS +LE L E++ +LR+++ G+++L +HR Sbjct: 97 LKDTKLW--IIMEYLGGGSALDLLEPGP----LDETQIATILREILKGLDYLHSEKKIHR 150 Query: 135 DIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDE-QFVSLYGTEEYLHPDMYERAVLRKD 193 DIK N++ + E G+ KL DFG A +L D + + + GT ++ P++ + Sbjct: 151 DIKAANVL--LSEHGE--VKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIK------- 199 Query: 194 HQKKYGATVDLWSIGVTFYHAATGSLP 220 Q Y + D+WS+G+T A G P Sbjct: 200 -QSAYDSKADIWSLGITAIELARGEPP 225 >1KOA-A nrPDB Length = 491 Score = 78.2 bits (191), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 64/208 (30%), Positives = 92/208 (44%), Gaps = 17/208 (8%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLF-AI 73 LG GA V R + TG+ FA K F + +E + + L H +V L A Sbjct: 59 LGTGAFGVVHRVTERATGNNFAAK-FVMTPHESDKETVRKEIQTMSVLRHPTLVNLHDAF 117 Query: 74 EEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVH 133 E++ V+I EF G L+ + + N + E E + +R V G+ H+ EN VH Sbjct: 118 EDDNEM---VMIYEFMSGGELFEKVADEHNK--MSEDEAVEYMRQVCKGLCHMHENNYVH 172 Query: 134 RDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKD 193 D+KP NIM + KL DFG L+ + GT E+ P++ E Sbjct: 173 LDLKPENIMFTTKRSNE--LKLIDFGLTAHLDPKQSVKVTTGTAEFAAPEVAE------- 223 Query: 194 HQKKYGATVDLWSIGVTFYHAATGSLPF 221 K G D+WS+GV Y +G PF Sbjct: 224 -GKPVGYYTDMWSVGVLSYILLSGLSPF 250 >4YFF-A nrPDB Length = 311 Score = 78.2 bits (191), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 67/266 (25%), Positives = 121/266 (45%), Gaps = 37/266 (13%) Query: 13 DILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQM--REFEVLKKLNHKNIVKL 70 +I+G G+ V++GR + + AIK + ++ DV M RE +L +LNH +++ Sbjct: 48 EIIGSGSFGKVYKGRCRNK--IVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVIQF 105 Query: 71 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE-- 128 ++ + + ++ GSL+++L E L LI+ DV GM +L Sbjct: 106 VGACLNDPSQFAI-VTQYISGGSLFSLLHEQKRILDLQSK--LIIAVDVAKGMEYLHNLT 162 Query: 129 NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELE--DDEQFVSLYGTEEYLHPDMYE 186 I+HRD+ NI+ + EDG +V + DFG +R L+ D++ G ++ P+++ Sbjct: 163 QPIIHRDLNSHNIL--LYEDGHAV--VADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFT 218 Query: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAI 246 + +Y D++S + + TG +PF + ++ Y I +P Sbjct: 219 QCT-------RYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHI--RP---- 265 Query: 247 SGVQKAENGPIDWSGDMPVSCSLSRG 272 PI +S P+S L RG Sbjct: 266 ---------PIGYSIPKPISSLLIRG 282 >3UTO-A nrPDB Length = 573 Score = 77.8 bits (190), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 64/208 (30%), Positives = 92/208 (44%), Gaps = 17/208 (8%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLF-AI 73 LG GA V R + TG+ FA K F + +E + + L H +V L A Sbjct: 165 LGTGAFGVVHRVTERATGNNFAAK-FVMTPHESDKETVRKEIQTMSVLRHPTLVNLHDAF 223 Query: 74 EEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVH 133 E++ V+I EF G L+ + + N + E E + +R V G+ H+ EN VH Sbjct: 224 EDDNEM---VMIYEFMSGGELFEKVADEHNK--MSEDEAVEYMRQVCKGLCHMHENNYVH 278 Query: 134 RDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKD 193 D+KP NIM + KL DFG L+ + GT E+ P++ E Sbjct: 279 LDLKPENIMFTTKRSNE--LKLIDFGLTAHLDPKQSVKVTTGTAEFAAPEVAE------- 329 Query: 194 HQKKYGATVDLWSIGVTFYHAATGSLPF 221 K G D+WS+GV Y +G PF Sbjct: 330 -GKPVGYYTDMWSVGVLSYILLSGLSPF 356 >4BBM-A nrPDB Length = 331 Score = 77.8 bits (190), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 69/221 (31%), Positives = 105/221 (47%), Gaps = 37/221 (16%) Query: 14 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVD-VQMREFEVLKKLNHKNIVKLFA 72 ++G+G+ V + R+K TG + AIK F + V + MRE ++LK+L H+N+V L Sbjct: 32 LVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHENLVNLLE 91 Query: 73 IEEETTTRHKVLIMEFCPCGSLYTVLEE----PSNAYGLPESEFLIVLRDVVGGMNHLRE 128 + ++ + L+ EF +T+L++ P+ GL L ++ G+ Sbjct: 92 VCKKKKRWY--LVFEFVD----HTILDDLELFPN---GLDYQVVQKYLFQIINGIGFCHS 142 Query: 129 NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAAR------ELEDDEQFVSLYGTEEYLHP 182 + I+HRDIKP NI+ + + G V KL DFG AR E+ DDE Y E L Sbjct: 143 HNIIHRDIKPENIL--VSQSG--VVKLCDFGFARTLAAPGEVYDDEVATRWYRAPELLVG 198 Query: 183 DMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRP 223 D+ KYG VD+W+IG G P P Sbjct: 199 DV------------KYGKAVDVWAIGCLVTEMFMGE-PLFP 226 >6E2O-A nrPDB Length = 295 Score = 77.8 bits (190), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 64/228 (28%), Positives = 102/228 (44%), Gaps = 22/228 (9%) Query: 14 ILGQGATANVFRGRHKKTGDLFAIKVF--NNISFLRPVDVQMREFEVLKKLNHKNIVK-L 70 +LG+G V+ GR AIK + + +P+ E + K L HKNIV+ L Sbjct: 29 VLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPL---HEEIALHKHLKHKNIVQYL 85 Query: 71 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 130 + E + + ME P GSL +L E + ++ G+ +L +N Sbjct: 86 GSFSENGFIK---IFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQ 142 Query: 131 IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLY-GTEEYLHPDMYERAV 189 IVHRDIK N++ V K++DFG ++ L + GT +Y+ P++ ++ Sbjct: 143 IVHRDIKGDNVLI---NTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKG- 198 Query: 190 LRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKI 237 + YG D+WS+G T ATG PF P+ M+K+ Sbjct: 199 -----PRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQ---AAMFKV 238 >5X3F-B nrPDB Length = 393 Score = 77.8 bits (190), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 62/233 (26%), Positives = 118/233 (50%), Gaps = 33/233 (14%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNN--ISFLRPVDVQMREFEVLKKLNHKNIVKL-F 71 LG G+ V +HK++G+ +A+K+ + + L+ ++ + E +L+ +N +VKL F Sbjct: 92 LGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEF 151 Query: 72 AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGI 131 + ++ + ++ME+ G +++ L + P + F +V +L + Sbjct: 152 SFKDNSNL---YMVMEYVAGGEMFSHLRRIGR-FSEPHARFYAA--QIVLTFEYLHSLDL 205 Query: 132 VHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLR 191 ++RD+KP N++ D Q ++TDFG A+ ++ + +L GT EYL P++ +L Sbjct: 206 IYRDLKPENLLI----DQQGYIQVTDFGFAKRVKG--RTWTLCGTPEYLAPEI----ILS 255 Query: 192 KDHQKKYGATVDLWSIGVTFYHAATGSLPF---RPFEGPRRNKEVMYKIITGK 241 K + K VD W++GV Y A G PF +P ++ KI++GK Sbjct: 256 KGYNK----AVDWWALGVLIYEMAAGYPPFFADQPI-------QIYEKIVSGK 297 >5DYK-A nrPDB Length = 853 Score = 77.4 bits (189), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 63/231 (27%), Positives = 112/231 (48%), Gaps = 25/231 (10%) Query: 14 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFL---RPVDVQMREFEVLKKLNHKNIVKL 70 I+G+G V HK T +A+K + S + + ++++ E E+ + +H I++L Sbjct: 546 IIGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLNQQNNIKL-EREITAENDHPFIIRL 604 Query: 71 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 130 + +++ + E G LY + + L +S+ L ++ + +L E Sbjct: 605 --VRTFKDSKYFYFLTELVTGGELYDAIRKLG---LLSKSQAQFYLGSIILAIEYLHERN 659 Query: 131 IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVL 190 IV+RD+KP NI+ D Q KL DFG A++++ + +L GT Y+ P++ Sbjct: 660 IVYRDLKPENILL----DKQGYVKLIDFGCAKKVQG--RAYTLVGTPHYMAPEVI----- 708 Query: 191 RKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 241 K YG TVD+W++G+ Y G LPF E + E+ I+TG+ Sbjct: 709 ---LGKGYGCTVDIWALGICLYEFICGPLPFGNDEEDQL--EIFRDILTGQ 754 >2VD5-A nrPDB Length = 412 Score = 77.0 bits (188), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 66/213 (30%), Positives = 105/213 (49%), Gaps = 15/213 (7%) Query: 14 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQM--REFEVLKKLNHKNIVKL- 70 ++G+GA + V + K+TG ++A+K+ N L+ +V E +VL + + I +L Sbjct: 68 VIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDRRWITQLH 127 Query: 71 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 130 FA ++E + L+ME+ G L T+L + +P L ++V ++ + G Sbjct: 128 FAFQDEN---YLYLVMEYYVGGDLLTLLSKFGER--IPAEMARFYLAEIVMAIDSVHRLG 182 Query: 131 IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSL--YGTEEYLHPDMYERA 188 VHRDIKP NI+ D +L DFG+ +L D SL GT +YL P++ + A Sbjct: 183 YVHRDIKPDNILL----DRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQ-A 237 Query: 189 VLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 V YG D W++GV Y G PF Sbjct: 238 VGGGPGTGSYGPECDWWALGVFAYEMFYGQTPF 270 >3Q53-A nrPDB Length = 306 Score = 77.0 bits (188), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 66/230 (28%), Positives = 107/230 (46%), Gaps = 25/230 (10%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 74 +GQGA+ V+ TG AI+ N + ++ + E V+++ + NIV ++ Sbjct: 29 IGQGASGTVYTAMDVATGQEVAIRQMN-LQQQPKKELIINEILVMRENKNPNIVNY--LD 85 Query: 75 EETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHR 134 ++ME+ GSL V+ E + E + V R+ + + L N ++HR Sbjct: 86 SYLVGDELWVVMEYLAGGSLTDVVTETC----MDEGQIAAVCRECLQALEFLHSNQVIHR 141 Query: 135 DIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVS-LYGTEEYLHPDMYERAVLRKD 193 DIK NI+ +G DG KLTDFG ++ ++ S + GT ++ P++ R Sbjct: 142 DIKSDNIL--LGMDGS--VKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTR------ 191 Query: 194 HQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIIT-GKP 242 K YG VD+WS+G+ G P+ E P R +Y I T G P Sbjct: 192 --KAYGPKVDIWSLGIMAIEMIEGEPPYL-NENPLR---ALYLIATNGTP 235 >3NIZ-A nrPDB Length = 311 Score = 76.6 bits (187), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 63/176 (35%), Positives = 89/176 (50%), Gaps = 26/176 (14%) Query: 53 MREFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEF 112 +RE +LK+L+H NIV L I+ + R L+ EF L VL+E N GL +S+ Sbjct: 67 IREISLLKELHHPNIVSL--IDVIHSERCLTLVFEFME-KDLKKVLDE--NKTGLQDSQI 121 Query: 113 LIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAAREL-----EDD 167 I L ++ G+ H ++ I+HRD+KP N++ I DG KL DFG AR Sbjct: 122 KIYLYQLLRGVAHCHQHRILHRDLKPQNLL--INSDG--ALKLADFGLARAFGIPVRSYT 177 Query: 168 EQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRP 223 + V+L+ Y PD+ + KKY +VD+WSIG F TG P P Sbjct: 178 HEVVTLW----YRAPDVLMGS-------KKYSTSVDIWSIGCIFAEMITGK-PLFP 221 >4B8L-A nrPDB Length = 286 Score = 76.6 bits (187), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 61/209 (29%), Positives = 100/209 (47%), Gaps = 20/209 (9%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKV-FNNISFLRPVDVQMR-EFEVLKKLNHKNIVKLFA 72 LG+G NV+ R K+ + A+KV F + V+ Q+R E E+ L H NI++++ Sbjct: 23 LGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRREIEIQSHLRHPNILRMYN 82 Query: 73 IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIV 132 + + L++EF P G LY L++ E + ++ +++ E ++ Sbjct: 83 YFHDR--KRIYLMLEFAPRGELYKELQKHGR---FDEQRSATFMEELADALHYCHERKVI 137 Query: 133 HRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRK 192 HRDIKP N++ +G G+ K+ DFG + + ++ GT +YL P+M E Sbjct: 138 HRDIKPENLL--MGYKGE--LKIADFGWSVHAPSLRR-RTMCGTLDYLPPEMIE------ 186 Query: 193 DHQKKYGATVDLWSIGVTFYHAATGSLPF 221 K + VDLW GV Y G PF Sbjct: 187 --GKTHDEKVDLWCAGVLCYEFLVGMPPF 213 >4AF3-A nrPDB Length = 292 Score = 76.6 bits (187), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 70/242 (28%), Positives = 113/242 (46%), Gaps = 23/242 (9%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKV-FNNISFLRPVDVQMR-EFEVLKKLNHKNIVKLFA 72 LG+G NV+ R KK+ + A+KV F + V+ Q+R E E+ L+H NI++L+ Sbjct: 31 LGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYN 90 Query: 73 IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIV 132 + R LI+E+ P G LY L++ E ++ ++ + + ++ Sbjct: 91 YFYDR--RRIYLILEYAPRGELYKELQKSCT---FDEQRTATIMEELADALMYCHGKKVI 145 Query: 133 HRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRK 192 HRDIKP N++ + + K+ DFG + + ++ GT +YL P+M E Sbjct: 146 HRDIKPENLLLGL----KGELKIADFGWSVHAPSLRR-KTMCGTLDYLPPEMIE------ 194 Query: 193 DHQKKYGATVDLWSIGVTFYHAATGSLPFRPF---EGPRRNKEVMYKIITGKPSGAISGV 249 + + VDLW IGV Y G+ PF E RR +V K P+GA + Sbjct: 195 --GRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPTGAQDLI 252 Query: 250 QK 251 K Sbjct: 253 SK 254 >3TAC-A nrPDB Length = 361 Score = 76.3 bits (186), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 62/239 (25%), Positives = 114/239 (47%), Gaps = 24/239 (10%) Query: 8 LWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISF-----LRPVDVQMREFEVLKKL 62 ++ L +++G+G + V R +++TG FA+K+ + F L D++ RE + L Sbjct: 27 VYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLK-REASICHML 85 Query: 63 NHKNIVKLFAIEEETTTRHKVLIMEFCPCGSL-YTVLEEPSNAYGLPESEFLIVLRDVVG 121 H +IV+L +E ++ ++ EF L + +++ + E+ +R ++ Sbjct: 86 KHPHIVEL--LETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILE 143 Query: 122 GMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFV-SLYGTEEYL 180 + + +N I+HRD+KP ++ E+ V KL FG A +L + GT ++ Sbjct: 144 ALRYCHDNNIIHRDVKPHCVLLASKENSAPV-KLGGFGVAIQLGESGLVAGGRVGTPHFM 202 Query: 181 HPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF-----RPFEGPRRNKEVM 234 P++ +R + YG VD+W GV + +G LPF R FEG + K M Sbjct: 203 APEVVKR--------EPYGKPVDVWGCGVILFILLSGCLPFYGTKERLFEGIIKGKYKM 253 >4J52-A nrPDB Length = 293 Score = 76.3 bits (186), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 63/211 (29%), Positives = 96/211 (45%), Gaps = 20/211 (9%) Query: 14 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRP--VDVQMREFEVLKKLNHKNIVKLF 71 LG+G A F T ++FA K+ L+P + E + + L H+++V Sbjct: 21 FLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFH 80 Query: 72 AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGI 131 E+ +++E C SL LE L E E LR +V G +L N + Sbjct: 81 GFFEDND--FVFVVLELCRRRSL---LELHKRRKALTEPEARYYLRQIVLGCQYLHRNRV 135 Query: 132 VHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELE-DDEQFVSLYGTEEYLHPDMYERAVL 190 +HRD+K GN+ + ED + K+ DFG A ++E D E+ L GT Y+ P++ + Sbjct: 136 IHRDLKLGNLF--LNEDLE--VKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSK--- 188 Query: 191 RKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 K + VD+WSIG Y G PF Sbjct: 189 -----KGHSFEVDVWSIGCIMYTLLVGKPPF 214 >6CQF-A nrPDB Length = 297 Score = 75.9 bits (185), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 61/201 (30%), Positives = 97/201 (48%), Gaps = 24/201 (11%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRP---VDVQMREFEVLKKLNHKNIVKLF 71 LG G VF+ R K +GDL A+K+ + P V +E +LK H NIV Sbjct: 24 LGGGTYGEVFKARDKVSGDLVALKMVK----MEPDDDVSTLQKEILILKTCRHANIV--- 76 Query: 72 AIEEETTTRHKVLI-MEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 130 A K+ I MEFC GSL + + + L E + V R+V+ G+ +L Sbjct: 77 AYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGS---LSELQISYVCREVLQGLAYLHSQK 133 Query: 131 IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD-EQFVSLYGTEEYLHPDMYERAV 189 +HRDIK NI+ I + G+ +L DFG + ++ + ++ GT ++ P++ A+ Sbjct: 134 KIHRDIKGANIL--INDAGE--VRLADFGISAQIGATLARRLAFIGTPYWMAPEVAAVAL 189 Query: 190 LRKDHQKKYGATVDLWSIGVT 210 + Y D+WS+G+T Sbjct: 190 -----KGGYNELCDIWSLGIT 205 >3UC3-A nrPDB Length = 361 Score = 75.9 bits (185), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 68/229 (29%), Positives = 104/229 (45%), Gaps = 20/229 (8%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 74 +G G R K T +L A+K + + +VQ RE + L H NIV+ E Sbjct: 28 IGSGNFGVARLMRDKLTKELVAVKYIERGAAIDE-NVQ-REIINHRSLRHPNIVRF--KE 83 Query: 75 EETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHR 134 T H +IME+ G LY E NA E E + ++ G+++ I HR Sbjct: 84 VILTPTHLAIIMEYASGGELY---ERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHR 140 Query: 135 DIKPGNIMRVIGEDGQSV--YKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRK 192 D+K N + DG K+ DFG ++ Q S GT Y+ P++ +LR+ Sbjct: 141 DLKLENTLL----DGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEV----LLRQ 192 Query: 193 DHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 241 ++ G D+WS GVT Y G+ PF E PR ++ + +I++ K Sbjct: 193 EYD---GKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVK 238 >2OU7-A nrPDB Length = 335 Score = 75.9 bits (185), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 63/211 (29%), Positives = 96/211 (45%), Gaps = 20/211 (9%) Query: 14 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRP--VDVQMREFEVLKKLNHKNIVKLF 71 LG+G A F T ++FA K+ L+P + E + + L H+++V Sbjct: 48 FLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFH 107 Query: 72 AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGI 131 E+ +++E C SL LE L E E LR +V G +L N + Sbjct: 108 GFFEDND--FVFVVLELCRRRSL---LELHKRRKALTEPEARYYLRQIVLGCQYLHRNRV 162 Query: 132 VHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELE-DDEQFVSLYGTEEYLHPDMYERAVL 190 +HRD+K GN+ + ED + K+ DFG A ++E D E+ L GT Y+ P++ + Sbjct: 163 IHRDLKLGNLF--LNEDLE--VKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSK--- 215 Query: 191 RKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 K + VD+WSIG Y G PF Sbjct: 216 -----KGHSFEVDVWSIGCIMYTLLVGKPPF 241 >2JDO-A nrPDB Length = 342 Score = 75.9 bits (185), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 64/219 (29%), Positives = 96/219 (43%), Gaps = 36/219 (16%) Query: 14 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHKNIVKL- 70 +LG+G V R K TG +A+K+ + +V + E VL+ H + L Sbjct: 17 LLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALK 76 Query: 71 FAIEEETTTRHKVLIMEFCPCGSLYTVL-------EEPSNAYGLPESEFLIVLRDVVGGM 123 +A + T +ME+ G L+ L EE + YG ++V + Sbjct: 77 YAFQ---THDRLCFVMEYANGGELFFHLSRERVFTEERARFYGA----------EIVSAL 123 Query: 124 NHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARE-LEDDEQFVSLYGTEEYLHP 182 +L +V+RDIK N+M + +DG K+TDFG +E + D + GT EYL P Sbjct: 124 EYLHSRDVVYRDIKLENLM--LDKDGH--IKITDFGLCKEGISDGATMKTFCGTPEYLAP 179 Query: 183 DMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 ++ E YG VD W +GV Y G LPF Sbjct: 180 EVLE--------DNDYGRAVDWWGLGVVMYEMMCGRLPF 210 >3H4J-B nrPDB Length = 336 Score = 75.5 bits (184), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 64/227 (28%), Positives = 108/227 (47%), Gaps = 25/227 (11%) Query: 1 MQSTSNHL--WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMR---E 55 M + H+ +++ + LG+G+ V H KT A+K F + L+ D+ MR E Sbjct: 1 MAISKRHIGPYIIRETLGEGSFGKVKLATHYKTQQKVALK-FISRQLLKKSDMHMRVERE 59 Query: 56 FEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIV 115 LK L H +I+KL+ + TT V+++E+ G L+ + E + E E Sbjct: 60 ISYLKLLRHPHIIKLYDVI--TTPTDIVMVIEYA-GGELFDYIVEKKR---MTEDEGRRF 113 Query: 116 LRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYG 175 + ++ + + + IVHRD+KP N++ +D +V K+ DFG + + D + G Sbjct: 114 FQQIICAIEYCHRHKIVHRDLKPENLLL---DDNLNV-KIADFGLSNIMTDGNFLKTSCG 169 Query: 176 TEEYLHPDMYERAVLRKDHQKKY-GATVDLWSIGVTFYHAATGSLPF 221 + Y P++ + K Y G VD+WS G+ Y G LPF Sbjct: 170 SPNYAAPEVI--------NGKLYAGPEVDVWSCGIVLYVMLVGRLPF 208 >3MIA-A nrPDB Length = 351 Score = 75.1 bits (183), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 63/220 (28%), Positives = 99/220 (45%), Gaps = 34/220 (15%) Query: 15 LGQGATANVFRGRHKKTGDLFAIK--VFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFA 72 +GQG VF+ RH+KTG A+K + N P+ +RE ++L+ L H+N+V L Sbjct: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPI-TALREIKILQLLKHENVVNLIE 83 Query: 73 IEEETTTRHK------VLIMEFCP---CGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 123 I + + L+ +FC G L VL + SE V++ ++ G+ Sbjct: 84 ICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK------FTLSEIKRVMQMLLNGL 137 Query: 124 NHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAAREL-----EDDEQFVSLYGTEE 178 ++ N I+HRD+K N++ I DG V KL DFG AR ++ + T Sbjct: 138 YYIHRNKILHRDMKAANVL--ITRDG--VLKLADFGLARAFSLAKNSQPNRYTNRVVTLW 193 Query: 179 YLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGS 218 Y P++ ++ YG +DLW G T S Sbjct: 194 YRPPELLL-------GERDYGPPIDLWGAGCIMAEMWTRS 226 >2XIK-A nrPDB Length = 294 Score = 74.7 bits (182), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 56/209 (26%), Positives = 101/209 (48%), Gaps = 19/209 (9%) Query: 13 DILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFA 72 D +G+G+ V++G T ++ AIK+ + ++ +E VL + + I + F Sbjct: 25 DRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYITRYFG 84 Query: 73 IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIV 132 ++T +IME+ GS +L+ L E+ +LR+++ G+++L + Sbjct: 85 SYLKSTKLW--IIMEYLGGGSALDLLKPGP----LEETYIATILREILKGLDYLHSERKI 138 Query: 133 HRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDE-QFVSLYGTEEYLHPDMYERAVLR 191 HRDIK N++ + E G KL DFG A +L D + + + GT ++ P++ + Sbjct: 139 HRDIKAANVL--LSEQGD--VKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIK----- 189 Query: 192 KDHQKKYGATVDLWSIGVTFYHAATGSLP 220 Q Y D+WS+G+T A G P Sbjct: 190 ---QSAYDFKADIWSLGITAIELAKGEPP 215 >4AW2-A nrPDB Length = 437 Score = 74.7 bits (182), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 60/213 (28%), Positives = 101/213 (47%), Gaps = 17/213 (7%) Query: 14 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQM--REFEVLKKLNHKNIVKL- 70 ++G+GA V + K +FA+K+ N L+ + E +VL + K I L Sbjct: 81 VIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDSKWITTLH 140 Query: 71 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 130 +A +++ L+M++ G L T+L + + LPE L ++V ++ + + Sbjct: 141 YAFQDDNNL---YLVMDYYVGGDLLTLLSKFEDR--LPEEMARFYLAEMVIAIDSVHQLH 195 Query: 131 IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVS--LYGTEEYLHPDMYERA 188 VHRDIKP NI+ D +L DFG+ +L +D S GT +Y+ P++ + Sbjct: 196 YVHRDIKPDNILM----DMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAM 251 Query: 189 VLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 + + +YG D WS+GV Y G PF Sbjct: 252 ---EGGKGRYGPECDWWSLGVCMYEMLYGETPF 281 >5J5T-A nrPDB Length = 370 Score = 74.7 bits (182), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 64/201 (31%), Positives = 98/201 (48%), Gaps = 24/201 (11%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVD---VQMREFEVLKKLNHKNIVKLF 71 +G G +V++ R+ TG+L AIKV L P + V +E ++K H NIV F Sbjct: 12 IGSGTYGDVYKARNVNTGELAAIKVIK----LEPGEDFAVVQQEIIMMKDCKHPNIVAYF 67 Query: 72 AIEEETTTRHKVLI-MEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 130 R K+ I MEFC GSL + L E + V R+ + G+ +L G Sbjct: 68 G---SYLRRDKLWICMEFCGGGSLQDIYHVTGP---LSELQIAYVSRETLQGLYYLHSKG 121 Query: 131 IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD-EQFVSLYGTEEYLHPDMYERAV 189 +HRDIK NI+ + ++G KL DFG + ++ + + GT ++ P++ AV Sbjct: 122 KMHRDIKGANIL--LTDNGH--VKLADFGVSAQITATIAKRKAFIGTPYWMAPEV--AAV 175 Query: 190 LRKDHQKKYGATVDLWSIGVT 210 RK Y DLW++G+T Sbjct: 176 ERKG---GYNQLCDLWAVGIT 193 >4Y83-A nrPDB Length = 332 Score = 74.3 bits (181), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 64/211 (30%), Positives = 101/211 (47%), Gaps = 25/211 (11%) Query: 12 SDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLF 71 SD + +GA V+ + KT A K+ F +P DV E+ H+NI +L+ Sbjct: 78 SDFIPRGAFGKVYLAQDIKTKKRMACKLIPVDQF-KPSDV-----EIQACFRHENIAELY 131 Query: 72 AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGI 131 T H L ME GS VLE+ + + E E + V + V+ G++ L + Sbjct: 132 GAVLWGETVH--LFMEAGEGGS---VLEKLESCGPMREFEIIWVTKHVLKGLDFLHSKKV 186 Query: 132 VHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFV-SLYGTEEYLHPDMYERAVL 190 +H DIKP NI+ + + L DFG + ++ +D F L GTE Y+ P++ +L Sbjct: 187 IHHDIKPSNIVFM-----STKAVLVDFGLSVQMTEDVYFPKDLRGTEIYMSPEV----IL 237 Query: 191 RKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 + H K D++S+G T H TG+ P+ Sbjct: 238 CRGHSTK----ADIYSLGATLIHMQTGTPPW 264 >4I6B-A nrPDB Length = 308 Score = 74.3 bits (181), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 60/210 (28%), Positives = 102/210 (48%), Gaps = 20/210 (9%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQM--REFEVLKKLNHKNIVKLFA 72 LG+G A + ++A K+ + +P + +E E+ + L+HK++V+ + Sbjct: 36 LGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDKEIELHRILHHKHVVQFYH 95 Query: 73 IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIV 132 E+ + +++E+C S+ +L+ L E E LR +V G+ +L E I+ Sbjct: 96 YFEDKENIY--ILLEYCSRRSMAHILKARKV---LTEPEVRYYLRQIVSGLKYLHEQEIL 150 Query: 133 HRDIKPGNIMRVIGEDGQSVYKLTDFGAARELED-DEQFVSLYGTEEYLHPDMYERAVLR 191 HRD+K GN I E + K+ DFG A LE + + ++ GT YL P+ VL Sbjct: 151 HRDLKLGNFF--INESME--LKVGDFGLAARLEPLEHRRRTICGTPNYLSPE-----VLN 201 Query: 192 KDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 K + +GA D+W++G Y G PF Sbjct: 202 K---QGHGAESDIWALGCVMYTMLLGRPPF 228 >2HW6-A nrPDB Length = 307 Score = 74.3 bits (181), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 66/221 (29%), Positives = 104/221 (47%), Gaps = 19/221 (8%) Query: 10 LLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKL-NHKNIV 68 L S++LG+GA A V + G +A+K+ + V RE E L + +KNI+ Sbjct: 16 LTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRV-FREVETLYQCQGNKNIL 74 Query: 69 KLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE 128 +L E+ T + L+ E GS+ +++ + E E V+RDV ++ L Sbjct: 75 ELIEFFEDDTRFY--LVFEKLQGGSILAHIQKQKH---FNEREASRVVRDVAAALDFLHT 129 Query: 129 NGIVHRDIKPGNIMRVIGEDGQSVYKLTDF--GAARELEDD------EQFVSLYGTEEYL 180 GI HRD+KP NI+ E V K+ DF G+ +L + + + G+ EY+ Sbjct: 130 KGIAHRDLKPENILCESPEKVSPV-KICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYM 188 Query: 181 HPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 P++ E + D Y DLWS+GV Y +G PF Sbjct: 189 APEVVE---VFTDQATFYDKRCDLWSLGVVLYIMLSGYPPF 226 >5YKS-A nrPDB Length = 377 Score = 74.3 bits (181), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 61/217 (28%), Positives = 105/217 (48%), Gaps = 17/217 (7%) Query: 8 LWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQM-REFEVLKKLNHKN 66 L+ L LG+G A V RH TG+ A+KV + + +E +K + H N Sbjct: 36 LYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHPN 95 Query: 67 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 126 IV+L+ + + T + LI+E G ++ + + + GL E +V +++ Sbjct: 96 IVRLYEVIDTQTKLY--LILELGDGGDMFDYIMK--HEEGLNEDLAKKYFAQIVHAISYC 151 Query: 127 RENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYE 186 + +VHRD+KP N V+ + Q + KLTDFG + + + ++ + G+ Y P+ Sbjct: 152 HKLHVVHRDLKPEN---VVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPE--- 205 Query: 187 RAVLRKDHQKKYGA-TVDLWSIGVTFYHAATGSLPFR 222 +L D +Y A VD+WS+GV + G PF+ Sbjct: 206 --ILLGD---EYDAPAVDIWSLGVILFMLVCGQPPFQ 237 >5G6V-A nrPDB Length = 324 Score = 73.9 bits (180), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 67/236 (28%), Positives = 106/236 (44%), Gaps = 27/236 (11%) Query: 13 DILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFA 72 D LG+G A V++G+ K T +L A+K +RE +LK L H NIV L Sbjct: 8 DKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHD 67 Query: 73 IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIV 132 I T + L+ E+ L L++ N + + + L ++ G+ + ++ Sbjct: 68 IIH--TEKSLTLVFEYLD-KDLKQYLDDCGNIINMHNVK--LFLFQLLRGLAYCHRQKVL 122 Query: 133 HRDIKPGNIMRVIGEDGQSVYKLTDFGAARELED-----DEQFVSLYGTEEYLHPDMYER 187 HRD+KP N++ I E G+ KL DFG AR D + V+L+ Y PD+ Sbjct: 123 HRDLKPQNLL--INERGE--LKLADFGLARAKSIPTKTYDNEVVTLW----YRPPDILLG 174 Query: 188 AVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS 243 + Y +D+W +G FY ATG P P +++I+ G P+ Sbjct: 175 ST-------DYSTQIDMWGVGCIFYEMATGR-PLFPGSTVEEQLHFIFRIL-GTPT 221 >5F9E-A nrPDB Length = 353 Score = 73.9 bits (180), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 63/215 (29%), Positives = 97/215 (45%), Gaps = 21/215 (9%) Query: 11 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLK-KLNHKNI 67 L +LG+G+ VF KKT FAIK L DV+ M E VL H + Sbjct: 23 LHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFL 82 Query: 68 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 127 +F + T + +ME+ G L ++ + + L + F +++ G+ L Sbjct: 83 THMFCTFQ--TKENLFFVMEYLNGGDLMYHIQS-CHKFDLSRATFYAA--EIILGLQFLH 137 Query: 128 ENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARE-LEDDEQFVSLYGTEEYLHPDMYE 186 GIV+RD+K NI+ + +DG K+ DFG +E + D + GT +Y+ P++ Sbjct: 138 SKGIVYRDLKLDNIL--LDKDGH--IKIADFGMCKENMLGDAKTNEFCGTPDYIAPEIL- 192 Query: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 +KY +VD WS GV Y G PF Sbjct: 193 -------LGQKYNHSVDWWSFGVLLYEMLIGQSPF 220 >3ORP-A nrPDB Length = 311 Score = 73.9 bits (180), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 69/236 (29%), Positives = 104/236 (44%), Gaps = 38/236 (16%) Query: 3 STSNHL---WLLSDILGQGATANVFRGRHKKTGDLFAIKVFN-----NISF-LRPVDVQM 53 +T +HL + L +ILG G + V R + A+KV + SF LR Sbjct: 5 TTPSHLSDRYELGEILGFGGMSEVHLARDLRDHRDVAVKVLRADLARDPSFYLR----FR 60 Query: 54 REFEVLKKLNHKNIVKLFAIEEETTTRHKV--LIMEFCPCGSLYTVL--EEPSNAYGLPE 109 RE + LNH IV ++ E T + ++ME+ +L ++ E P + Sbjct: 61 REAQNAAALNHPAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVHTEGP-----MTP 115 Query: 110 SEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD-- 167 + V+ D +N +NGI+HRD+KP NIM + K+ DFG AR + D Sbjct: 116 KRAIEVIADACQALNFSHQNGIIHRDVKPANIMI----SATNAVKVMDFGIARAIADSGN 171 Query: 168 --EQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 Q ++ GT +YL P+ R D A D++S+G Y TG PF Sbjct: 172 SVTQTAAVIGTAQYLSPEQ-----ARGD---SVDARSDVYSLGCVLYEVLTGEPPF 219 >4JG6-A nrPDB Length = 355 Score = 73.9 bits (180), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 64/230 (27%), Positives = 109/230 (47%), Gaps = 23/230 (10%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLN-HKNIVKLFAI 73 +G G+ + R HK T FA+K+ + S P + E E+L + H NI+ L + Sbjct: 43 IGVGSYSVCKRCIHKATNMEFAVKIIDK-SKRDPTE----EIEILLRYGQHPNIITLKDV 97 Query: 74 EEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVH 133 ++ ++ ++ E G L L++ E E VL + + +L G+VH Sbjct: 98 YDDG--KYVYVVTELMKGGEL---LDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVH 152 Query: 134 RDIKPGNIMRVIGEDGQSVYKLTDFGAARELE-DDEQFVSLYGTEEYLHPDMYERAVLRK 192 RD+KP NI+ V ++ DFG A++L ++ ++ T ++ P++ ER Sbjct: 153 RDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLER----- 207 Query: 193 DHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRN-KEVMYKIITGK 241 + Y A D+WS+GV Y TG PF GP +E++ +I +GK Sbjct: 208 ---QGYDAACDIWSLGVLLYTMLTGYTPFA--NGPDDTPEEILARIGSGK 252 >4GS6-A nrPDB Length = 315 Score = 73.6 bits (179), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 57/220 (25%), Positives = 104/220 (47%), Gaps = 25/220 (11%) Query: 11 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKL 70 + +++G+GA V + + + AIK + S + V++R+ L ++NH NIVKL Sbjct: 13 VEEVVGRGAFGVVCKAKWRAKD--VAIKQIESESERKAFIVELRQ---LSRVNHPNIVKL 67 Query: 71 FAIEEETTTRHKVLIMEFCPCGSLYTVLE--EPSNAYGLPES-EFLIVLRDVVGGMNHLR 127 + L+ME+ GSLY VL EP Y + + + V ++ ++ Sbjct: 68 YG----ACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQ 123 Query: 128 ENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYER 187 ++HRD+KP N++ V G +V K+ DFG A +++ + G+ ++ P+++E Sbjct: 124 PKALIHRDLKPPNLLLVA---GGTVLKICDFGTACDIQT--HMTNNKGSAAWMAPEVFEG 178 Query: 188 AVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGP 227 + Y D++S G+ + T PF GP Sbjct: 179 S--------NYSEKCDVFSWGIILWEVITRRKPFDEIGGP 210 >3ALO-A nrPDB Length = 327 Score = 73.2 bits (178), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 68/256 (26%), Positives = 114/256 (44%), Gaps = 39/256 (15%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNI-------SFLRPVDVQMREFEVLKKLNHKNI 67 +G+GA +V + HK +G + A+K + L +DV MR + I Sbjct: 30 IGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDC------PYI 83 Query: 68 VKLFAI---EEETTTRHKVLIMEFCPC-GSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 123 V+ + E + +++ F +Y+VL++ +PE + V + Sbjct: 84 VQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDD-----VIPEEILGKITLATVKAL 138 Query: 124 NHLREN-GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHP 182 NHL+EN I+HRDIKP NI+ D KL DFG + +L D G Y+ P Sbjct: 139 NHLKENLKIIHRDIKPSNILL----DRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAP 194 Query: 183 DMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNK--EVMYKIITG 240 + + + R+ Y D+WS+G+T Y ATG P+ P+ N + + +++ G Sbjct: 195 ERIDPSASRQ----GYDVRSDVWSLGITLYELATGRFPY-----PKWNSVFDQLTQVVKG 245 Query: 241 KPSGAISGVQKAENGP 256 P +S ++ E P Sbjct: 246 DPP-QLSNSEEREFSP 260 >5AIR-A nrPDB Length = 430 Score = 73.2 bits (178), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 56/206 (27%), Positives = 103/206 (50%), Gaps = 23/206 (11%) Query: 12 SDILGQGATANVFRGRHKKTGDLFAIK-VFNNISFLRPVDVQMREFEVLKKLNHKNIVKL 70 + ++G G+ V++ + +G+L AIK V + F + RE ++++KL+H NIV+L Sbjct: 69 TKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRF------KNRELQIMRKLDHCNIVRL 122 Query: 71 ----FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNA-YGLPESEFLIVLRDVVGGMNH 125 ++ E+ + L++++ P ++Y V S A LP + + + + + Sbjct: 123 RYFFYSSGEKKDEVYLNLVLDYVP-ETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAY 181 Query: 126 LRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMY 185 + GI HRDIKP N++ + +V KL DFG+A++L E VS + Y P++ Sbjct: 182 IHSFGICHRDIKPQNLLL---DPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELI 238 Query: 186 ERAVLRKDHQKKYGATVDLWSIGVTF 211 A Y +++D+WS G Sbjct: 239 FGAT-------DYTSSIDVWSAGCVL 257 >4YNZ-A nrPDB Length = 342 Score = 73.2 bits (178), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 59/214 (27%), Positives = 97/214 (45%), Gaps = 17/214 (7%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQM-REFEVLKKLNHKNI 67 + L LG+G T V G H T AIK+ N V +++ RE +LK + H ++ Sbjct: 12 YRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHV 71 Query: 68 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 127 +KL + E ++ L++E G L+ L + L E R ++ ++ Sbjct: 72 LKLHDVYE--NKKYLYLVLEHVSGGELFDYLVKKGR---LTPKEARKFFRQIISALDFCH 126 Query: 128 ENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYER 187 + I HRD+KP N++ D ++ ++ DFG A D + G+ Y P+ Sbjct: 127 SHSICHRDLKPENLLL----DERNNIRIADFGMASLQVGDSLLETSCGSPHYACPE---- 178 Query: 188 AVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 V+R +K G D+WS GV + G+LPF Sbjct: 179 -VIRG--EKYDGRKADVWSCGVILFALLVGALPF 209 >1NY3-A nrPDB Length = 400 Score = 73.2 bits (178), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 55/213 (25%), Positives = 98/213 (46%), Gaps = 19/213 (8%) Query: 12 SDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNH-KNIVKL 70 S +LG G V + +K+T + FA+K+ + R RE E+ + + +IV++ Sbjct: 67 SQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKAR------REVELHWRASQCPHIVRI 120 Query: 71 FAIEEETTTRHKVL--IMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE 128 + E K L +ME G L++ +++ + E E +++ + + +L Sbjct: 121 VDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQ-AFTEREASEIMKSIGEAIQYLHS 179 Query: 129 NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERA 188 I HRD+KP N++ + ++ KLTDFG A+E + T Y+ P++ Sbjct: 180 INIAHRDVKPENLL-YTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVL--- 235 Query: 189 VLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 +KY + D+WS+GV Y G PF Sbjct: 236 -----GPEKYDKSCDMWSLGVIMYILLCGYPPF 263 >4NIF-A nrPDB Length = 333 Score = 73.2 bits (178), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 62/236 (26%), Positives = 111/236 (47%), Gaps = 23/236 (9%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLN-HKNI 67 +++ + +G G+ + R HK T +A+KV + S P + E E+L + H NI Sbjct: 10 YVVKETIGVGSYSECKRCVHKATNMEYAVKVIDK-SKRDPSE----EIEILLRYGQHPNI 64 Query: 68 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 127 + L + ++ +H L+ E G L L++ E E VL + + +L Sbjct: 65 ITLKDVYDDG--KHVYLVTELMRGGEL---LDKILRQKFFSEREASFVLHTIGKTVEYLH 119 Query: 128 ENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELE-DDEQFVSLYGTEEYLHPDMYE 186 G+VHRD+KP NI+ V ++ DFG A++L ++ ++ T ++ P++ + Sbjct: 120 SQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLK 179 Query: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRN-KEVMYKIITGK 241 R + Y D+WS+G+ Y G PF GP +E++ +I +GK Sbjct: 180 R--------QGYDEGCDIWSLGILLYTMLAGYTPFA--NGPSDTPEEILTRIGSGK 225 >2OZA-A nrPDB Length = 356 Score = 73.2 bits (178), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 55/213 (25%), Positives = 98/213 (46%), Gaps = 19/213 (8%) Query: 12 SDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNH-KNIVKL 70 S +LG G V + +K+T + FA+K+ + R RE E+ + + +IV++ Sbjct: 23 SQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKAR------REVELHWRASQCPHIVRI 76 Query: 71 FAIEEETTTRHKVL--IMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE 128 + E K L +ME G L++ +++ + E E +++ + + +L Sbjct: 77 VDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQ-AFTEREASEIMKSIGEAIQYLHS 135 Query: 129 NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERA 188 I HRD+KP N++ + ++ KLTDFG A+E + T Y+ P++ Sbjct: 136 INIAHRDVKPENLL-YTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVL--- 191 Query: 189 VLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 +KY + D+WS+GV Y G PF Sbjct: 192 -----GPEKYDKSCDMWSLGVIMYILLCGYPPF 219 >3HKO-A nrPDB Length = 345 Score = 72.8 bits (177), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 72/257 (28%), Positives = 112/257 (43%), Gaps = 56/257 (21%) Query: 11 LSDILGQGATANVFRGRHKKTGDLFAIKVFNN--ISFLRPVDVQMREFEV--LKKLNHKN 66 L +GQG+ V +T + AIK+ N I + P DV+ + EV +KKL+H N Sbjct: 30 LKGAIGQGSYGVVRVAIENQTRAIRAIKIMNKNKIRQINPKDVERIKTEVRLMKKLHHPN 89 Query: 67 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVL---------------------------E 99 I +L+ + E+ ++ L+ME C G L L E Sbjct: 90 IARLYEVYEDE--QYICLVMELCHGGHLLDKLNVFIDDSTGKCAMDVVKTQICPCPECNE 147 Query: 100 EPSNA--YGLPES------EFLI--VLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDG 149 E N +G ES E LI ++R + +++L GI HRDIKP N + + Sbjct: 148 EAINGSIHGFRESLDFVQREKLISNIMRQIFSALHYLHNQGICHRDIKPENFLFSTNKSF 207 Query: 150 QSVYKLTDFGAARE---LEDDEQF--VSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDL 204 + KL DFG ++E L + E + + GT ++ P++ + YG D Sbjct: 208 E--IKLVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEVLNTT------NESYGPKCDA 259 Query: 205 WSIGVTFYHAATGSLPF 221 WS GV + G++PF Sbjct: 260 WSAGVLLHLLLMGAVPF 276 >4C0T-A nrPDB Length = 974 Score = 72.8 bits (177), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 56/228 (24%), Positives = 104/228 (45%), Gaps = 44/228 (19%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFE--VLKKLNHK-NIVKLF 71 LG+G+ + V K TG +A+KV + ++ V+ E L +L+++ ++ L+ Sbjct: 274 LGEGSYSTVILATDKITGKQYAVKVLDKRHIIKEKKVKYVNIEKHALNRLSNRLGVISLY 333 Query: 72 AIEEETTTRHKVLIMEFCPCGSLYTVL-------EEPSNAYGLPESEFLIVLRDVVGGMN 124 ++ + + ++++ G L T++ EE + +G ++ + Sbjct: 334 FTFQDKDSLY--FVLDYASNGELLTLIKRYNTLNEECTRHFGA----------QILDAIK 381 Query: 125 HLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELED----------DEQFVSLY 174 ++ +NG++HRD+KP NI+ D + ++TDFG AR LE D + S Sbjct: 382 YMHDNGVIHRDLKPENILL----DDKMRIQITDFGTARLLEKKNDESEEYPVDVRAKSFV 437 Query: 175 GTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFR 222 GT EY+ P++ E K G D+W+ G Y G PF+ Sbjct: 438 GTAEYVSPELLE--------NKYCGKPGDVWAFGCIIYQMIAGKPPFK 477 >1U59-A nrPDB Length = 287 Score = 72.4 bits (176), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 65/236 (27%), Positives = 111/236 (47%), Gaps = 21/236 (8%) Query: 10 LLSDI-LGQGATANVFRG--RHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKN 66 L++DI LG G +V +G R +K AIKV + + MRE +++ +L++ Sbjct: 12 LIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPY 71 Query: 67 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 126 IV+L + + +L+ME G L+ L +P S +L V GM +L Sbjct: 72 IVRLIGVCQAEAL---MLVMEMAGGGPLHKFLVGKREE--IPVSNVAELLHQVSMGMKYL 126 Query: 127 RENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYE 186 E VHRD+ N++ V + K++DFG ++ L D+ + + ++ Sbjct: 127 EEKNFVHRDLAARNVLLV----NRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAP 182 Query: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVMYKIITGK 241 + + +K+ + D+WS GVT + A + G P++ +GP EVM I GK Sbjct: 183 ECI----NFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGP----EVMAFIEQGK 230 >3KA0-A nrPDB Length = 320 Score = 72.0 bits (175), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 55/213 (25%), Positives = 97/213 (45%), Gaps = 19/213 (8%) Query: 12 SDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNH-KNIVKL 70 S +LG G V + +K+T + FA+K+ + R RE E+ + + +IV++ Sbjct: 21 SQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKAR------REVELHWRASQCPHIVRI 74 Query: 71 FAIEEETTTRHKVL--IMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE 128 + E K L +ME G L++ +++ + E E +++ + + +L Sbjct: 75 VDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQ-AFTEREASEIMKSIGEAIQYLHS 133 Query: 129 NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERA 188 I HRD+KP N++ + ++ KLTDFG A+E T Y+ P++ Sbjct: 134 INIAHRDVKPENLL-YTSKRPNAILKLTDFGFAKETTSHNSLTEPCYTPYYVAPEVL--- 189 Query: 189 VLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 +KY + D+WS+GV Y G PF Sbjct: 190 -----GPEKYDKSCDMWSLGVIMYILLCGYPPF 217 >5O0Y-A nrPDB Length = 579 Score = 72.0 bits (175), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 56/181 (30%), Positives = 91/181 (50%), Gaps = 25/181 (13%) Query: 54 REFEVLKKLNHKNIVKL---FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPES 110 RE+ + K+L+H IVKL F+++ ++ ++E+C L L++ + E Sbjct: 337 REYRIHKELDHPRIVKLYDYFSLDTDSF----CTVLEYCEGNDLDFYLKQHK---LMSEK 389 Query: 111 EFLIVLRDVVGGMNHLRE--NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD- 167 E ++ +V + +L E I+H D+KPGNI+ V G + K+TDFG ++ ++DD Sbjct: 390 EARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEI-KITDFGLSKIMDDDS 448 Query: 168 -------EQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLP 220 E GT YL P+ + V+ K+ K VD+WS+GV FY G P Sbjct: 449 YNSVDGMELTSQGAGTYWYLPPECF---VVGKE-PPKISNKVDVWSVGVIFYQCLYGRKP 504 Query: 221 F 221 F Sbjct: 505 F 505 >3C51-A nrPDB Length = 543 Score = 72.0 bits (175), Expect = 9e-13, Method: Compositional matrix adjust. Identities = 65/236 (27%), Positives = 111/236 (47%), Gaps = 21/236 (8%) Query: 9 WLLS-DILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHK 65 W L +LG+G VF + K TG L+A K N + Q M E ++L K++ + Sbjct: 186 WFLDFRVLGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILAKVHSR 245 Query: 66 NIVKL-FAIEEETTTRHKVLIMEFCPCGSL-YTVLEEPSNAYGLPESEFLIVLRDVVGGM 123 IV L +A E +T L+M G + Y + + G E + +V G+ Sbjct: 246 FIVSLAYAFETKTDL---CLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQIVSGL 302 Query: 124 NHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLY-GTEEYLHP 182 HL + I++RD+KP N++ + +DG +++D G A EL+ + Y GT ++ P Sbjct: 303 EHLHQRNIIYRDLKPENVL--LDDDGN--VRISDLGLAVELKAGQTKTKGYAGTPGFMAP 358 Query: 183 DMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKII 238 ++ ++Y +VD +++GVT Y PFR NKE+ +++ Sbjct: 359 ELL--------LGEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKQRVL 406 >5KKR-C nrPDB Length = 395 Score = 72.0 bits (175), Expect = 9e-13, Method: Compositional matrix adjust. Identities = 68/212 (32%), Positives = 102/212 (48%), Gaps = 23/212 (10%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPV--DVQMREFEVLKKLNHKNIVKLFA 72 LG G VF+ HK +G + A K+ + ++P + +RE +VL + N IV + Sbjct: 76 LGAGNGGVVFKVSHKPSGLVMARKLIH--LEIKPAIRNQIIRELQVLHECNSPYIVGFYG 133 Query: 73 IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE-NGI 131 + + ME GSL VL++ A +PE V V+ G+ +LRE + I Sbjct: 134 --AFYSDGEISICMEHMDGGSLDQVLKK---AGRIPEQILGKVSIAVIKGLTYLREKHKI 188 Query: 132 VHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLR 191 +HRD+KP NI+ + G+ KL DFG + +L D S GT Y+ P ER L+ Sbjct: 189 MHRDVKPSNIL--VNSRGE--IKLCDFGVSGQL-IDSMANSFVGTRSYMSP---ER--LQ 238 Query: 192 KDHQKKYGATVDLWSIGVTFYHAATGSLPFRP 223 H Y D+WS+G++ A G P P Sbjct: 239 GTH---YSVQSDIWSMGLSLVEMAVGRYPIPP 267 >1FOT-A nrPDB Length = 318 Score = 71.6 bits (174), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 55/209 (26%), Positives = 99/209 (47%), Gaps = 21/209 (10%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNN--ISFLRPVDVQMREFEVLKKLNHKNIVKLFA 72 LG G+ V R + G +A+KV + L+ V+ E +L + H I++++ Sbjct: 14 LGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTHPFIIRMWG 73 Query: 73 IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIV 132 ++ + +IM++ G L+++L + S + P ++F +V + +L I+ Sbjct: 74 TFQDA--QQIFMIMDYIEGGELFSLLRK-SQRFPNPVAKFYAA--EVCLALEYLHSKDII 128 Query: 133 HRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRK 192 +RD+KP NI+ D K+TDFG A+ + D +L GT +Y+ P++ Sbjct: 129 YRDLKPENILL----DKNGHIKITDFGFAKYVPDVT--YTLCGTPDYIAPEVVS------ 176 Query: 193 DHQKKYGATVDLWSIGVTFYHAATGSLPF 221 K Y ++D WS G+ Y G PF Sbjct: 177 --TKPYNKSIDWWSFGILIYEMLAGYTPF 203 >4UY9-A nrPDB Length = 323 Score = 71.6 bits (174), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 64/228 (28%), Positives = 104/228 (45%), Gaps = 31/228 (13%) Query: 11 LSDILGQGATANVFRGRHKKTGDLFAIKVFN-----NISFLRPVDVQMREFEVLKKLNHK 65 L +I+G G V+R GD A+K +IS + ++ +E ++ L H Sbjct: 13 LEEIIGIGGFGKVYRAFW--IGDEVAVKAARHDPDEDIS--QTIENVRQEAKLFAMLKHP 68 Query: 66 NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 125 NI+ L + + + L+MEF G L VL + +P + + GMN+ Sbjct: 69 NIIALRGVCLKEP--NLCLVMEFARGGPLNRVL----SGKRIPPDILVNWAVQIARGMNY 122 Query: 126 LRENGIV---HRDIKPGNIMRVI----GEDGQSVYKLTDFGAARELEDDEQFVSLYGTEE 178 L + IV HRD+K NI+ + G+ + K+TDFG ARE + +S GT Sbjct: 123 LHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTK-MSAAGTYA 181 Query: 179 YLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEG 226 ++ P++ ++ K D+WS GV + TG +PFR +G Sbjct: 182 WMAPEVIRASMFSKGS--------DVWSYGVLLWELLTGEVPFRGIDG 221 >3LM0-A nrPDB Length = 327 Score = 71.6 bits (174), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 64/230 (27%), Positives = 110/230 (47%), Gaps = 28/230 (12%) Query: 1 MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ---MREFE 57 M++ +N L S LG+G A V + K TG +A K R D + + E Sbjct: 23 MENFNNFYILTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRR--RGQDCRAEILHEIA 80 Query: 58 VLKKLNH-KNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVL 116 VL+ ++ L + E T+ +LI+E+ G +++ L P A + E++ + ++ Sbjct: 81 VLELAKSCPRVINLHEVYENTS--EIILILEYAAGGEIFS-LCLPELAEMVSENDVIRLI 137 Query: 117 RDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVY-----KLTDFGAARELEDDEQFV 171 + ++ G+ +L +N IVH D+KP NI+ S+Y K+ DFG +R++ + Sbjct: 138 KQILEGVYYLHQNNIVHLDLKPQNILL------SSIYPLGDIKIVDFGMSRKIGHACELR 191 Query: 172 SLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 + GT EYL P+ +L D D+W+IG+ Y T + PF Sbjct: 192 EIMGTPEYLAPE-----ILNYD---PITTATDMWNIGIIAYMLLTHTSPF 233 >3EQC-A nrPDB Length = 360 Score = 71.6 bits (174), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 68/212 (32%), Positives = 102/212 (48%), Gaps = 23/212 (10%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPV--DVQMREFEVLKKLNHKNIVKLFA 72 LG G VF+ HK +G + A K+ + ++P + +RE +VL + N IV + Sbjct: 41 LGAGNGGVVFKVSHKPSGLVMARKLIH--LEIKPAIRNQIIRELQVLHECNSPYIVGFYG 98 Query: 73 IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE-NGI 131 + + ME GSL VL++ A +PE V V+ G+ +LRE + I Sbjct: 99 --AFYSDGEISICMEHMDGGSLDQVLKK---AGRIPEQILGKVSIAVIKGLTYLREKHKI 153 Query: 132 VHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLR 191 +HRD+KP NI+ + G+ KL DFG + +L D S GT Y+ P ER L+ Sbjct: 154 MHRDVKPSNIL--VNSRGE--IKLCDFGVSGQL-IDSMANSFVGTRSYMSP---ER--LQ 203 Query: 192 KDHQKKYGATVDLWSIGVTFYHAATGSLPFRP 223 H Y D+WS+G++ A G P P Sbjct: 204 GTH---YSVQSDIWSMGLSLVEMAVGRYPIPP 232 >4KS7-A nrPDB Length = 292 Score = 71.6 bits (174), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 53/208 (25%), Positives = 100/208 (48%), Gaps = 20/208 (9%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 74 +G+G+T V R K +G A+K+ + R ++ E +++ H N+V+++ + Sbjct: 31 IGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRR-ELLFNEVVIMRDYQHFNVVEMY--K 87 Query: 75 EETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHR 134 ++MEF G+L ++ + L E + V V+ + +L G++HR Sbjct: 88 SYLVGEELWVLMEFLQGGALTDIVSQ----VRLNEEQIATVCEAVLQALAYLHAQGVIHR 143 Query: 135 DIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD-EQFVSLYGTEEYLHPDMYERAVLRKD 193 DIK +I+ + DG+ KL+DFG ++ D + SL GT ++ P++ R++ Sbjct: 144 DIKSDSILLTL--DGR--VKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSL---- 195 Query: 194 HQKKYGATVDLWSIGVTFYHAATGSLPF 221 Y VD+WS+G+ G P+ Sbjct: 196 ----YATEVDIWSLGIMVIEMVDGEPPY 219 >5VD3-A nrPDB Length = 311 Score = 71.2 bits (173), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 63/206 (30%), Positives = 93/206 (45%), Gaps = 26/206 (12%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVL---KKLNHKNIVKLF 71 LG G+ VF+ R K+ G L+A+K + F P D + EV K H V+L Sbjct: 65 LGHGSYGEVFKVRSKEDGRLYAVKR-SMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRL- 122 Query: 72 AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYG--LPESEFLIVLRDVVGGMNHLREN 129 E+ +L ++ CG L++ A+G LPE++ LRD + + HL Sbjct: 123 ---EQAWEEGGILYLQTELCG---PSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQ 176 Query: 130 GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAV 189 G+VH D+KP NI +G G+ KL DFG EL G Y+ P++ Sbjct: 177 GLVHLDVKPANIF--LGPRGRC--KLGDFGLLVELGTAGAGEVQEGDPRYMAPELL---- 228 Query: 190 LRKDHQKKYGATVDLWSIGVTFYHAA 215 Q YG D++S+G+T A Sbjct: 229 -----QGSYGTAADVFSLGLTILEVA 249 >2GCD-A nrPDB Length = 309 Score = 71.2 bits (173), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 65/219 (29%), Positives = 107/219 (48%), Gaps = 27/219 (12%) Query: 10 LLSDI--LGQGATANVFRGRHKKTGDLFAIKVFN---NISFLRPVDVQMREFEVLKKLNH 64 L SD+ +G G+ V+ R + ++ AIK + S + D+ ++E L+KL H Sbjct: 16 LFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDI-IKEVRFLQKLRH 74 Query: 65 KNIVKLFA--IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGG 122 N ++ + E T L+ME+C GS +LE + L E E V + G Sbjct: 75 PNTIQYRGCYLREHTAW----LVMEYC-LGSASDLLE--VHKKPLQEVEIAAVTHGALQG 127 Query: 123 MNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHP 182 + +L + ++HRD+K GNI+ + E G + KL DFG+A + FV GT ++ P Sbjct: 128 LAYLHSHNMIHRDVKAGNIL--LSEPG--LVKLGDFGSASIMAPANSFV---GTPYWMAP 180 Query: 183 DMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 ++ +L D + +Y VD+WS+G+T A P Sbjct: 181 EV----ILAMD-EGQYDGKVDVWSLGITCIELAERKPPL 214 >3UDB-A nrPDB Length = 317 Score = 71.2 bits (173), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 66/238 (27%), Positives = 107/238 (44%), Gaps = 23/238 (9%) Query: 5 SNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQM-REFEVLKKLN 63 S+ L+ DI G G R K+ +L A+K I +D + RE + L Sbjct: 18 SDRYELVKDI-GAGNFGVARLMRDKQANELVAVKY---IERGEKIDENVKREIINHRSLR 73 Query: 64 HKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 123 H NIV+ E T H ++ME+ G L+ E NA E E + ++ G+ Sbjct: 74 HPNIVRF--KEVILTPTHLAIVMEYASGGELF---ERICNAGRFSEDEARFFFQQLISGV 128 Query: 124 NHLRENGIVHRDIKPGNIMRVIGEDGQSV--YKLTDFGAARELEDDEQFVSLYGTEEYLH 181 ++ + HRD+K N + DG K+ DFG ++ Q S GT Y+ Sbjct: 129 SYAHAMQVAHRDLKLENTLL----DGSPAPRLKIADFGYSKASVLHSQPKSAVGTPAYIA 184 Query: 182 PDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIIT 239 P++ +L+K++ G D+WS GVT Y G+ PF E P+ ++ +++I+ Sbjct: 185 PEV----LLKKEYD---GKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILN 235 >3ORZ-A nrPDB Length = 316 Score = 71.2 bits (173), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 56/217 (25%), Positives = 98/217 (45%), Gaps = 22/217 (10%) Query: 11 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLR--PVDVQMREFEVLKKLNHKNIV 68 ILG+G+ + V R T +AIK+ ++ V RE +V+ +L+H V Sbjct: 41 FGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFV 100 Query: 69 KLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE 128 KL+ ++ + + + G L + + + E+ ++V + +L Sbjct: 101 KLYFCFQDDEKLY--FGLSYAKNGELLKYIRKIGS---FDETCTRFYTAEIVSALEYLHG 155 Query: 129 NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFV---SLYGTEEYLHPDMY 185 GI+HRD+KP NI+ + ED ++TDFG A+ L + + S GT +Y+ P++ Sbjct: 156 KGIIHRDLKPENIL--LNEDMH--IQITDFGTAKVLSPESKQARANSFVGTAQYVSPELL 211 Query: 186 ERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFR 222 +K + DLW++G Y G PFR Sbjct: 212 T--------EKSACKSSDLWALGCIIYQLVAGLPPFR 240 >1U5R-A nrPDB Length = 348 Score = 70.9 bits (172), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 65/219 (29%), Positives = 107/219 (48%), Gaps = 27/219 (12%) Query: 10 LLSDI--LGQGATANVFRGRHKKTGDLFAIKVFN---NISFLRPVDVQMREFEVLKKLNH 64 L SD+ +G G+ V+ R + ++ AIK + S + D+ ++E L+KL H Sbjct: 55 LFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDI-IKEVRFLQKLRH 113 Query: 65 KNIVKLFA--IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGG 122 N ++ + E T L+ME+C GS +LE + L E E V + G Sbjct: 114 PNTIQYRGCYLREHTAW----LVMEYC-LGSASDLLE--VHKKPLQEVEIAAVTHGALQG 166 Query: 123 MNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHP 182 + +L + ++HRD+K GNI+ + E G + KL DFG+A + FV GT ++ P Sbjct: 167 LAYLHSHNMIHRDVKAGNIL--LSEPG--LVKLGDFGSASIMAPANSFV---GTPYWMAP 219 Query: 183 DMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 ++ +L D + +Y VD+WS+G+T A P Sbjct: 220 EV----ILAMD-EGQYDGKVDVWSLGITCIELAERKPPL 253 >3FXW-A nrPDB Length = 336 Score = 70.9 bits (172), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 58/215 (26%), Positives = 98/215 (45%), Gaps = 20/215 (9%) Query: 10 LLSDILGQGATANVFRGRHKKTGDLFAIKV-FNNISFLRPVDVQMREFEVLKKLNHKNIV 68 L +LG G V H++TG A+K+ +++ + VD + +IV Sbjct: 32 LSKQVLGLGVNGKVLECFHRRTGQKCALKLLYDSPKARQEVDHHW------QASGGPHIV 85 Query: 69 KLFAIEEET--TTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 126 + + E R ++IME G L++ ++E + E E ++RD+ + L Sbjct: 86 CILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQ-AFTEREAAEIMRDIGTAIQFL 144 Query: 127 RENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYE 186 + I HRD+KP N++ ++ +V KLTDFG A+E + Y T Y+ P++ Sbjct: 145 HSHNIAHRDVKPENLL-YTSKEKDAVLKLTDFGFAKETTQNALQTPCY-TPYYVAPEVL- 201 Query: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 +KY + D+WS+GV Y G PF Sbjct: 202 -------GPEKYDKSCDMWSLGVIMYILLCGFPPF 229 >5H2U-A nrPDB Length = 267 Score = 70.5 bits (171), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 62/208 (29%), Positives = 102/208 (49%), Gaps = 17/208 (8%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 74 LG G VF G K + AIKV + + L +Q E + +KKL HK+I+ L+A+ Sbjct: 14 LGSGYFGEVFEGLWKDRVQV-AIKVISRDNLLHQQMLQ-SEIQAMKKLRHKHILALYAVV 71 Query: 75 EETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHR 134 + +I E GSL +L + S+ LP SE L + V GM +L +HR Sbjct: 72 SVGDPVY--IITELMAKGSLLELLRD-SDEKVLPVSELLDIAWQVAEGMCYLESQNYIHR 128 Query: 135 DIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDH 194 D+ NI+ +GE+ ++ K+ DFG AR +++D +Y + ++ P Y+ Sbjct: 129 DLAARNIL--VGEN--TLCKVGDFGLARLIKED-----VYLSHDHNIP--YKWTAPEALS 177 Query: 195 QKKYGATVDLWSIGVTFYHA-ATGSLPF 221 + Y D+WS G+ + + G +P+ Sbjct: 178 RGHYSTKSDVWSFGILLHEMFSRGQVPY 205 >6BDL-A nrPDB Length = 347 Score = 70.5 bits (171), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 65/232 (28%), Positives = 109/232 (46%), Gaps = 31/232 (13%) Query: 13 DILGQGATANV----FRGRHKKTGDLFAIKVFN--NISFLRPVDVQMREFEVLKKLNHKN 66 D LG G V + KT FA+K+ +I R + E ++++ + Sbjct: 40 DTLGVGGFGRVELVQLKSEESKT---FAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDF 96 Query: 67 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 126 IV+L+ +++ ++ ++ME C G L+T+L + + +S VV +L Sbjct: 97 IVRLYRTFKDS--KYLYMLMEACLGGELWTILRDRGS---FEDSTTRFYTACVVEAFAYL 151 Query: 127 RENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYE 186 GI++RD+KP N++ D + KL DFG A+++ ++ + GT EY+ P++ Sbjct: 152 HSKGIIYRDLKPENLIL----DHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEI-- 205 Query: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKII 238 +L K H + D WS+G+ Y TGS PF GP K Y II Sbjct: 206 --ILNKGHD----ISADYWSLGILMYELLTGS---PPFSGPDPMK--TYNII 246 >4AN9-A nrPDB Length = 301 Score = 70.5 bits (171), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 68/213 (31%), Positives = 102/213 (47%), Gaps = 23/213 (10%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPV--DVQMREFEVLKKLNHKNIVKLFA 72 LG G VF+ HK +G + A K+ + ++P + +RE +VL + N IV + Sbjct: 17 LGAGNGGVVFKVSHKPSGLVMARKLIH--LEIKPAIRNQIIRELQVLHECNSPYIVGFYG 74 Query: 73 IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE-NGI 131 + + ME GSL VL++ A +PE V V+ G+ +LRE + I Sbjct: 75 --AFYSDGEISICMEHMDGGSLDQVLKK---AGRIPEQILGKVSIAVIKGLTYLREKHKI 129 Query: 132 VHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLR 191 +HRD+KP NI+ + G+ KL DFG + +L DE GT Y+ P ER L+ Sbjct: 130 MHRDVKPSNIL--VNSRGE--IKLCDFGVSGQL-IDEMANEFVGTRSYMSP---ER--LQ 179 Query: 192 KDHQKKYGATVDLWSIGVTFYHAATGSLPFRPF 224 H Y D+WS+G++ A G P P Sbjct: 180 GTH---YSVQSDIWSMGLSLVEMAVGRYPRPPM 209 >4FR4-A nrPDB Length = 384 Score = 70.5 bits (171), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 56/210 (26%), Positives = 105/210 (50%), Gaps = 18/210 (8%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHKNIVKL-F 71 +G+G+ V + T ++A+K N + +V+ +E ++++ L H +V L + Sbjct: 23 IGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQGLEHPFLVNLWY 82 Query: 72 AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGI 131 + ++E ++++ G L L++ N + E+ L + ++V +++L+ I Sbjct: 83 SFQDEEDM---FMVVDLLLGGDLRYHLQQ--NVHFKEETVKLFIC-ELVMALDYLQNQRI 136 Query: 132 VHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLR 191 +HRD+KP NI+ + E G +TDF A L + Q ++ GT+ Y+ P+M+ R Sbjct: 137 IHRDMKPDNIL--LDEHGH--VHITDFNIAAMLPRETQITTMAGTKPYMAPEMFSS---R 189 Query: 192 KDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 K Y VD WS+GVT Y G P+ Sbjct: 190 KG--AGYSFAVDWWSLGVTAYELLRGRRPY 217 >2A1A-B nrPDB Length = 284 Score = 70.1 bits (170), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 57/213 (26%), Positives = 100/213 (46%), Gaps = 36/213 (16%) Query: 13 DILGQGATANVFRGRHKKTGDLFAIK--VFNNISFLRPVDVQMREFEVLKKLNHKNIVKL 70 +++G G VF+ +H+ G + IK +NN + RE + L KL+H NIV Sbjct: 17 ELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNN-------EKAEREVKALAKLDHVNIVHY 69 Query: 71 ------FAIEEETTTRHK--------VLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVL 116 F + ET++++ + MEFC G+L +E+ L + L + Sbjct: 70 NGCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEK-RRGEKLDKVLALELF 128 Query: 117 RDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGT 176 + G++++ +++RD+KP NI V D + V K+ DFG L++D + GT Sbjct: 129 EQITKGVDYIHSKKLINRDLKPSNIFLV---DTKQV-KIGDFGLVTSLKNDGKRTRSKGT 184 Query: 177 EEYLHPDMYERAVLRKDHQKKYGATVDLWSIGV 209 Y+ P+ + YG VDL+++G+ Sbjct: 185 LRYMSPEQIS--------SQDYGKEVDLYALGL 209 >5KCV-A nrPDB Length = 460 Score = 70.1 bits (170), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 60/213 (28%), Positives = 96/213 (45%), Gaps = 23/213 (10%) Query: 14 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHKNIVKL- 70 +LG+G V + K TG +A+K+ + +V + E VL+ H + L Sbjct: 169 LLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALK 228 Query: 71 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR-EN 129 ++ + T +ME+ G L+ L S E ++V +++L E Sbjct: 229 YSFQ---THDRLCFVMEYANGGELFFHL---SRERVFSEDRARFYGAEIVSALDYLHSEK 282 Query: 130 GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARE-LEDDEQFVSLYGTEEYLHPDMYERA 188 +V+RD+K N+M + +DG K+TDFG +E ++D + GT EYL P++ E Sbjct: 283 NVVYRDLKLENLM--LDKDGH--IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLE-- 336 Query: 189 VLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 YG VD W +GV Y G LPF Sbjct: 337 ------DNDYGRAVDWWGLGVVMYEMMCGRLPF 363 >3DB8-A nrPDB Length = 317 Score = 70.1 bits (170), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 60/216 (27%), Positives = 101/216 (46%), Gaps = 20/216 (9%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRP--VDVQMREFEVLKKLNHKN 66 ++ LG+G A + T ++FA KV L+P + E + K L++ + Sbjct: 44 YMRGRFLGKGGFAKCYEITDMDTKEVFAGKVVPKSMLLKPHQKEKMSTEIAIHKSLDNPH 103 Query: 67 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 126 +V E+ + +++E C SL L + A PE+ + +R + G+ +L Sbjct: 104 VVGFHGFFEDDDFVY--VVLEICRRRSLLE-LHKRRKAVTEPEARYF--MRQTIQGVQYL 158 Query: 127 RENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELE-DDEQFVSLYGTEEYLHPDMY 185 N ++HRD+K GN+ D V K+ DFG A ++E D E+ L GT Y+ P++ Sbjct: 159 HNNRVIHRDLKLGNLFL---NDDMDV-KIGDFGLATKIEFDGERKKDLCGTPNYIAPEV- 213 Query: 186 ERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 + +K H + VD+WS+G Y G PF Sbjct: 214 ---LCKKGHSFE----VDIWSLGCILYTLLVGKPPF 242 >5X5O-A nrPDB Length = 310 Score = 70.1 bits (170), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 56/214 (26%), Positives = 98/214 (45%), Gaps = 28/214 (13%) Query: 16 GQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIEE 75 G G+ +V+R + A+K I +E E+L L+H+NI++ + + Sbjct: 24 GGGSFGSVYRAKWISQDKEVAVKKLLKIE---------KEAEILSVLSHRNIIQFYGVIL 74 Query: 76 ETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG---IV 132 E ++ E+ GSLY + + + + + DV GM++L ++ Sbjct: 75 EPPNYG--IVTEYASLGSLYDYINS-NRSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVI 131 Query: 133 HRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRK 192 HRD+K N+ VI DG V K+ DFGA+R + +SL GT ++ P++ + + + Sbjct: 132 HRDLKSRNV--VIAADG--VLKICDFGASR-FHNHTTHMSLVGTFPWMAPEVIQSLPVSE 186 Query: 193 DHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEG 226 T D +S GV + T +PF+ EG Sbjct: 187 --------TCDTYSYGVVLWEMLTREVPFKGLEG 212 >5B2L-A nrPDB Length = 324 Score = 69.7 bits (169), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 63/236 (26%), Positives = 104/236 (44%), Gaps = 29/236 (12%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFN-------NISFLRPVDVQMREFEVLKKLNHKNI 67 +G G V++ R +KTG + A+K N L +DV VLK + I Sbjct: 25 MGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDV------VLKSHDCPYI 78 Query: 68 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 127 V+ F T + + L ++ P +PE + +V + +L+ Sbjct: 79 VQCFGTFITNTDVFIAMELMGTSAEKLKKRMQGP-----IPERILGKMTVAIVKALYYLK 133 Query: 128 E-NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYE 186 E +G++HRD+KP NI+ + E GQ KL DFG + L D + G Y+ P E Sbjct: 134 EKHGVIHRDVKPSNIL--LDERGQ--IKLCDFGISGRLVDSKAKTRSAGCAAYMAP---E 186 Query: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKP 242 R + Y D+WS+G++ ATG P++ + + EV+ K++ +P Sbjct: 187 RIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYK---NCKTDFEVLTKVLQEEP 239 >2W96-B nrPDB Length = 306 Score = 69.7 bits (169), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 63/210 (30%), Positives = 98/210 (46%), Gaps = 33/210 (15%) Query: 15 LGQGATANVFRGRHKKTGDLFAIK---VFNNISFLRPVDVQMREFEVLKKLN---HKNIV 68 +G GA V++ R +G A+K V N L P+ +RE +L++L H N+V Sbjct: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGL-PIST-VREVALLRRLEAFEHPNVV 69 Query: 69 KLFAIEEETTTRHKV---LIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 125 +L + + T ++ L+ E L T L++ + GLP ++R + G++ Sbjct: 70 RLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDK-APPPGLPAETIKDLMRQFLRGLDF 127 Query: 126 LRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAAR----ELEDDEQFVSLYGTEEYLH 181 L N IVHRD+KP NI+ G KL DFG AR ++ D V+L+ Y Sbjct: 128 LHANCIVHRDLKPENILVTSG----GTVKLADFGLARIYSYQMALDPVVVTLW----YRA 179 Query: 182 PDMYERAVLRKDHQKKYGATVDLWSIGVTF 211 P++ Q Y VD+WS+G F Sbjct: 180 PEVL--------LQSTYATPVDMWSVGCIF 201 >5WAX-A nrPDB Length = 310 Score = 69.7 bits (169), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 63/231 (27%), Positives = 105/231 (45%), Gaps = 21/231 (9%) Query: 10 LLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVK 69 L+ DI G G R++ G L A+K + +VQ RE + L H NI++ Sbjct: 15 LVRDI-GSGNFGVARLMRNRADGQLVAVKYIERGEKIDE-NVQ-REIINHRSLRHPNIIR 71 Query: 70 LFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN 129 E T H ++ME+ G L+ E NA E E + ++ G+++ Sbjct: 72 F--KEVILTPTHLAIVMEYASGGELF---ERICNAGRFSEDEARFFFQQLISGVSYCHSM 126 Query: 130 GIVHRDIKPGNIMRVIGEDGQSV--YKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYER 187 + HRD+K N + DG + K+ DFG ++ Q S GT Y+ P++ Sbjct: 127 QVCHRDLKLENTLL----DGSTAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEV--- 179 Query: 188 AVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKII 238 +L+K++ G D+WS GVT Y G+ PF + P+ ++ + +I+ Sbjct: 180 -LLKKEYD---GKVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRIL 226 >3MV5-A nrPDB Length = 342 Score = 69.7 bits (169), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 60/213 (28%), Positives = 96/213 (45%), Gaps = 23/213 (10%) Query: 14 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHKNIVKL- 70 +LG+G V + K TG +A+K+ + +V + E VL+ H + L Sbjct: 17 LLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALK 76 Query: 71 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR-EN 129 ++ + T +ME+ G L+ L S E ++V +++L E Sbjct: 77 YSFQ---THDRLCFVMEYANGGELFFHL---SRERVFSEDRARFYGAEIVSALDYLHSEK 130 Query: 130 GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARE-LEDDEQFVSLYGTEEYLHPDMYERA 188 +V+RD+K N+M + +DG K+TDFG +E ++D + GT EYL P++ E Sbjct: 131 NVVYRDLKLENLM--LDKDGH--IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLE-- 184 Query: 189 VLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 YG VD W +GV Y G LPF Sbjct: 185 ------DNDYGRAVDWWGLGVVMYEMMCGRLPF 211 >2WQN-A nrPDB Length = 310 Score = 69.3 bits (168), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 58/214 (27%), Positives = 93/214 (43%), Gaps = 24/214 (11%) Query: 15 LGQGATANVFRGRHKKTGDLFAIK---VFNNISFLRPVDVQMREFEVLKKLNHKNIVKLF 71 +G+G + V+R G A+K +F+ + D ++E ++LK+LNH N++K + Sbjct: 40 IGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADC-IKEIDLLKQLNHPNVIKYY 98 Query: 72 A--IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGL-PESEFLIVLRDVVGGMNHLRE 128 A IE+ +++E G L +++ L PE + + H+ Sbjct: 99 ASFIEDNELN----IVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHMHS 154 Query: 129 NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFV-SLYGTEEYLHPDMYER 187 ++HRDIKP N+ I G V KL D G R SL GT Y+ P+ Sbjct: 155 RRVMHRDIKPANVF--ITATG--VVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPE---- 206 Query: 188 AVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 + H+ Y D+WS+G Y A PF Sbjct: 207 ----RIHENGYNFKSDIWSLGCLLYEMAALQSPF 236 >2OZO-A nrPDB Length = 613 Score = 69.3 bits (168), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 66/240 (27%), Positives = 113/240 (47%), Gaps = 29/240 (12%) Query: 10 LLSDI-LGQGATANVFRG--RHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKN 66 L++DI LG G +V +G R +K AIKV + + MRE +++ +L++ Sbjct: 338 LIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPY 397 Query: 67 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVL----EEPSNAYGLPESEFLIVLRDVVGG 122 IV+L + + +L+ME G L+ L EE +P S +L V G Sbjct: 398 IVRLIGVCQAEAL---MLVMEMAGGGPLHKFLVGKREE------IPVSNVAELLHQVSMG 448 Query: 123 MNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHP 182 M +L E VHR++ N++ V + K++DFG ++ L D+ + + ++ Sbjct: 449 MKYLEEKNFVHRNLAARNVLLV----NRHYAKISDFGLSKALGADDSYYTARSAGKWPLK 504 Query: 183 DMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVMYKIITGK 241 + + +K+ + D+WS GVT + A + G P++ +GP EVM I GK Sbjct: 505 WYAPECI----NFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGP----EVMAFIEQGK 556 >3DTC-A nrPDB Length = 271 Score = 69.3 bits (168), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 63/228 (27%), Positives = 103/228 (45%), Gaps = 31/228 (13%) Query: 11 LSDILGQGATANVFRGRHKKTGDLFAIKVFN-----NISFLRPVDVQMREFEVLKKLNHK 65 L +I+G G V+R GD A+K +IS + ++ +E ++ L H Sbjct: 11 LEEIIGIGGFGKVYRAFW--IGDEVAVKAARHDPDEDIS--QTIENVRQEAKLFAMLKHP 66 Query: 66 NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 125 NI+ L + + + L+MEF G L VL + +P + + GMN+ Sbjct: 67 NIIALRGVCLKEP--NLCLVMEFARGGPLNRVL----SGKRIPPDILVNWAVQIARGMNY 120 Query: 126 LRENGIV---HRDIKPGNIMRVI----GEDGQSVYKLTDFGAARELEDDEQFVSLYGTEE 178 L + IV HRD+K NI+ + G+ + K+TDFG ARE + +S G Sbjct: 121 LHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTK-MSAAGAYA 179 Query: 179 YLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEG 226 ++ P++ ++ K D+WS GV + TG +PFR +G Sbjct: 180 WMAPEVIRASMFSKGS--------DVWSYGVLLWELLTGEVPFRGIDG 219 >4FZF-B nrPDB Length = 283 Score = 69.3 bits (168), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 52/207 (25%), Positives = 98/207 (47%), Gaps = 19/207 (9%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 74 +G+G+ VF+G +T + AIK+ + ++ +E VL + + + K + Sbjct: 16 IGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSSYVTKYYGSY 75 Query: 75 EETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHR 134 + + +IME+ GS +L A E + +L++++ G+++L +HR Sbjct: 76 LKGSKLW--IIMEYLGGGSALDLLR----AGPFDEFQIATMLKEILKGLDYLHSEKKIHR 129 Query: 135 DIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDE-QFVSLYGTEEYLHPDMYERAVLRKD 193 DIK N++ + E G KL FG A +L D + + + GT ++ P++ + Sbjct: 130 DIKAANVL--LSEQGD--VKLAAFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQ------- 178 Query: 194 HQKKYGATVDLWSIGVTFYHAATGSLP 220 Q Y + D+WS+G+T A G P Sbjct: 179 -QSAYDSKADIWSLGITAIELAKGEPP 204 >3QGY-A nrPDB Length = 286 Score = 69.3 bits (168), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 59/193 (30%), Positives = 96/193 (49%), Gaps = 27/193 (13%) Query: 53 MREFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEF 112 + E EV+ KL+H +V+L+ + E L+ EF G L L GL +E Sbjct: 70 IEEAEVMMKLSHPKLVQLYGVCLEQAP--ICLVFEFMEHGCLSDYLR---TQRGLFAAET 124 Query: 113 LI-VLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFV 171 L+ + DV GM +L E ++HRD+ N + +GE+ V K++DFG R + DD Q+ Sbjct: 125 LLGMCLDVCEGMAYLEEACVIHRDLAARNCL--VGEN--QVIKVSDFGMTRFVLDD-QYT 179 Query: 172 SLYGTE---EYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHA-ATGSLPFRPFEGP 227 S GT+ ++ P+++ + +Y + D+WS GV + + G +P+ Sbjct: 180 SSTGTKFPVKWASPEVFSFS--------RYSSKSDVWSFGVLMWEVFSEGKIPYE----N 227 Query: 228 RRNKEVMYKIITG 240 R N EV+ I TG Sbjct: 228 RSNSEVVEDISTG 240 >5HI2-A nrPDB Length = 283 Score = 68.9 bits (167), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 58/212 (27%), Positives = 95/212 (44%), Gaps = 28/212 (13%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQM--REFEVLKKLNHKNIVKLFA 72 +G G+ V++G K GD+ A+K+ L P +Q E VL+K H NI+ Sbjct: 28 IGSGSFGTVYKG--KWHGDV-AVKM------LTPQQLQAFKNEVGVLRKTRHVNILLFMG 78 Query: 73 IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIV 132 +T ++ ++C SLY L + + + + + R GM++L I+ Sbjct: 79 Y---STKPQLAIVTQWCEGSSLYHHLHASETKFEM--KKLIDIARQTARGMDYLHAKSII 133 Query: 133 HRDIKPGNIMRVIGEDGQSVYKLTDFGAA---RELEDDEQFVSLYGTEEYLHPDMYERAV 189 HRD+K NI + ED + K+ DFG A QF L G+ ++ P+ V Sbjct: 134 HRDLKSNNIF--LHED--NTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPE-----V 184 Query: 190 LRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 +R Y D+++ G+ Y TG LP+ Sbjct: 185 IRMQDSNPYSFQSDVYAFGIVLYELMTGQLPY 216 >4YZB-A nrPDB Length = 491 Score = 68.9 bits (167), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 55/210 (26%), Positives = 98/210 (46%), Gaps = 17/210 (8%) Query: 14 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKL--NHKNIVKLF 71 +LG+G+ V + K TG +A+KV + + D ++ EV +H NI+KL+ Sbjct: 37 VLGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDKELLLKEVELLKKLDHPNIMKLY 96 Query: 72 AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGI 131 E+ + L+ E G L+ +E + E + ++R V+ G+ ++ +N I Sbjct: 97 EFFEDKG--YFYLVTEVYTGGELF---DEIISRKRFSEVDAARIIRQVLSGITYMHKNKI 151 Query: 132 VHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLR 191 VHRD+KP N++ + + + ++ DFG + E ++ GT Y+ P++ Sbjct: 152 VHRDLKPENLL-LENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEVL------ 204 Query: 192 KDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 Y D+WS GV Y +G PF Sbjct: 205 ---HGTYDEKCDVWSTGVILYILLSGCPPF 231 >3ZUT-A nrPDB Length = 362 Score = 68.9 bits (167), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 65/238 (27%), Positives = 107/238 (44%), Gaps = 23/238 (9%) Query: 5 SNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQM-REFEVLKKLN 63 S+ L+ DI G G R K++ +L A+K I +D + RE + L Sbjct: 18 SDRYELVKDI-GSGNFGVARLMRDKQSNELVAVKY---IERGEKIDENVKREIINHRSLR 73 Query: 64 HKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 123 H NIV+ E T H ++ME+ G L+ E NA E E + ++ G+ Sbjct: 74 HPNIVRF--KEVILTPTHLAIVMEYASGGELF---ERICNAGRFSEDEARFFFQQLISGV 128 Query: 124 NHLRENGIVHRDIKPGNIMRVIGEDGQSV--YKLTDFGAARELEDDEQFVSLYGTEEYLH 181 ++ + HRD+K N + DG K+ FG ++ Q S GT Y+ Sbjct: 129 SYCHAMQVCHRDLKLENTLL----DGSPAPRLKICAFGYSKSSVLHSQPKSTVGTPAYIA 184 Query: 182 PDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIIT 239 P++ +L+K++ G D+WS GVT Y G+ PF E P+ ++ +++I+ Sbjct: 185 PEV----LLKKEYD---GKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILN 235 >1G3N-A nrPDB Length = 326 Score = 68.6 bits (166), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 62/211 (29%), Positives = 89/211 (42%), Gaps = 34/211 (16%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ----------MREFEVLKKLN- 63 +G+GA VF+ R K G F L+ V VQ +RE VL+ L Sbjct: 19 IGEGAYGKVFKARDLKNGGRFVA--------LKRVRVQTGEEGMPLSTIREVAVLRHLET 70 Query: 64 --HKNIVKLFAI-EEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVV 120 H N+V+LF + T R L + F T + G+P ++ ++ Sbjct: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130 Query: 121 GGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYL 180 G++ L + +VHRD+KP NI+ + GQ KL DFG AR S+ T Y Sbjct: 131 RGLDFLHSHRVVHRDLKPQNIL--VTSSGQ--IKLADFGLARIYSFQMALTSVVVTLWYR 186 Query: 181 HPDMYERAVLRKDHQKKYGATVDLWSIGVTF 211 P++ Q Y VDLWS+G F Sbjct: 187 APEVL--------LQSSYATPVDLWSVGCIF 209 >6DBM-A nrPDB Length = 318 Score = 68.6 bits (166), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 52/206 (25%), Positives = 97/206 (47%), Gaps = 16/206 (7%) Query: 15 LGQGATANV----FRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKL 70 LG+G V + + TG++ A+K + + +E ++L+ L H++I+K Sbjct: 39 LGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAGPQHRSGWKQEIDILRTLYHEHIIKY 98 Query: 71 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 130 E+ L+ME+ P GSL L P ++ GL ++ L+ + + GM +L Sbjct: 99 KGCCEDAGAASLQLVMEYVPLGSLRDYL--PRHSIGL--AQLLLFAQQICEGMAYLHSQH 154 Query: 131 IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVL 190 +HRD+ N++ D + K+ DFG A+ + + ++ + E+ P + Sbjct: 155 YIHRDLAARNVLL----DNDRLVKIGDFGLAKAVPEGHEYYRV--REDGDSPVFWYAPEC 208 Query: 191 RKDHQKKYGATVDLWSIGVTFYHAAT 216 K+++ Y + D+WS GVT Y T Sbjct: 209 LKEYKFYYAS--DVWSFGVTLYELLT 232 >1CM8-A nrPDB Length = 367 Score = 68.6 bits (166), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 65/240 (27%), Positives = 105/240 (43%), Gaps = 35/240 (14%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQM------REFEVLKKLNHKNIV 68 +G GA V +TG AIK RP ++ RE +LK + H+N++ Sbjct: 33 VGSGAYGAVCSAVDGRTGAKVAIK-----KLYRPFQSELFAKRAYRELRLLKHMRHENVI 87 Query: 69 KLFAIEEETTTRHKV----LIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 124 L + T L+M F + T L + L E ++ ++ G+ Sbjct: 88 GLLDVFTPDETLDDFTDFYLVMPF-----MGTDLGKLMKHEKLGEDRIQFLVYQMLKGLR 142 Query: 125 HLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDM 184 ++ GI+HRD+KPGN+ + ED + K+ DFG AR+ D + T Y P++ Sbjct: 143 YIHAAGIIHRDLKPGNL--AVNEDCE--LKILDFGLARQA--DSEMTGYVVTRWYRAPEV 196 Query: 185 YERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSG 244 +L + +Y TVD+WS+G TG F+ + + KE+M +TG P Sbjct: 197 ----IL---NWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMK--VTGTPPA 247 >3A8W-A nrPDB Length = 345 Score = 68.6 bits (166), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 64/238 (26%), Positives = 111/238 (46%), Gaps = 29/238 (12%) Query: 14 ILGQGATANVFRGRHKKTGDLFAIKVF-----NNISFLRPVDVQMREFEVLKKLNHKNIV 68 ++G+G+ A V R KKT ++A+KV N+ + V + FE + NH +V Sbjct: 16 VIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFE--QASNHPFLV 73 Query: 69 KLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE 128 L + + T ++E+ G L ++ LPE ++ +N+L E Sbjct: 74 GLHSCFQ--TESRLFFVIEYVNGGDLMFHMQRQRK---LPEEHARFYSAEISLALNYLHE 128 Query: 129 NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARE-LEDDEQFVSLYGTEEYLHPDMYER 187 GI++RD+K N++ D + KLTD+G +E L + + GT Y+ P+ Sbjct: 129 RGIIYRDLKLDNVLL----DSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPE---- 180 Query: 188 AVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFR---PFEGPRRNKE-VMYKIITGK 241 +LR + YG +VD W++GV + G PF + P +N E ++++I K Sbjct: 181 -ILRG---EDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEK 234 >4F0G-A nrPDB Length = 287 Score = 68.2 bits (165), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 56/216 (25%), Positives = 95/216 (43%), Gaps = 23/216 (10%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVF------NNISFLRPVDVQMREFEVLKKLNHKNIV 68 +G+G V +GR K + AIK + RE ++ LNH NIV Sbjct: 27 IGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQREVFIMSNLNHPNIV 86 Query: 69 KLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE 128 KL+ + ++MEF PCG LY L + A+ + S L ++ D+ G+ +++ Sbjct: 87 KLYGLMHNPPR----MVMEFVPCGDLYHRLLD--KAHPIKWSVKLRLMLDIALGIEYMQN 140 Query: 129 NG--IVHRDIKPGNI-MRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMY 185 IVHRD++ NI ++ + E+ K+ DFG ++ + L G +++ P+ Sbjct: 141 QNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQ--QSVHSVSGLLGNFQWMAPETI 198 Query: 186 ERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 ++ Y D +S + Y TG PF Sbjct: 199 ------GAEEESYTEKADTYSFAMILYTILTGEGPF 228 >3SXS-A nrPDB Length = 268 Score = 68.2 bits (165), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 62/230 (26%), Positives = 106/230 (46%), Gaps = 28/230 (12%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 74 LG G V G+ K D+ A+K+ S D +E + + KL+H +VK + + Sbjct: 16 LGSGQFGVVKLGKWKGQYDV-AVKMIKEGSMSE--DEFFQEAQTMMKLSHPKLVKFYGVC 72 Query: 75 EETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHR 134 + + ++ E+ G L L S+ GL S+ L + DV GM L + +HR Sbjct: 73 SKEYPIY--IVTEYISNGCLLNYLR--SHGKGLEPSQLLEMCYDVCEGMAFLESHQFIHR 128 Query: 135 DIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTE---EYLHPDMYERAVLR 191 D+ N + D K++DFG R + DD Q+VS GT+ ++ P+++ Sbjct: 129 DLAARNCLV----DRDLCVKVSDFGMTRYVLDD-QYVSSVGTKFPVKWSAPEVF------ 177 Query: 192 KDHQKKYGATVDLWSIGVTFYHA-ATGSLPFRPFEGPRRNKEVMYKIITG 240 H KY + D+W+ G+ + + G +P+ + N EV+ K+ G Sbjct: 178 --HYFKYSSKSDVWAFGILMWEVFSLGKMPYDLY----TNSEVVLKVSQG 221 >3DLS-A nrPDB Length = 335 Score = 68.2 bits (165), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 65/221 (29%), Positives = 93/221 (42%), Gaps = 36/221 (16%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ-------MREFEVLKKLNHKNI 67 LG GA V+ K+ +K L ++ E +L ++ H NI Sbjct: 32 LGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANI 91 Query: 68 VKLFAIEEETTTRHKVLIMEFCPCG-SLYTV------LEEPSNAYGLPESEFLIVLRDVV 120 +K+ I E L+ME G L+ L+EP +Y + R +V Sbjct: 92 IKVLDIFENQGFFQ--LVMEKHGSGLDLFAFIDRHPRLDEPLASY---------IFRQLV 140 Query: 121 GGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYL 180 + +LR I+HRDIK NI VI ED KL DFG+A LE + F + GT EY Sbjct: 141 SAVGYLRLKDIIHRDIKDENI--VIAED--FTIKLIDFGSAAYLERGKLFYTFCGTIEYC 196 Query: 181 HPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 P++ R G +++WS+GVT Y PF Sbjct: 197 APEVLMGNPYR-------GPELEMWSLGVTLYTLVFEENPF 230 >4EQM-A nrPDB Length = 294 Score = 68.2 bits (165), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 63/228 (27%), Positives = 99/228 (43%), Gaps = 37/228 (16%) Query: 6 NHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQM------REFEVL 59 N + + D LG G + V+ + IKV F+ P + + RE Sbjct: 10 NERYKIVDKLGGGGMSTVYLAEDT----ILNIKVAIKAIFIPPREKEETLKRFEREVHNS 65 Query: 60 KKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYG-LPESEFLIVLRD 118 +L+H+NIV + ++EE + L+ME+ +L +E ++G L + Sbjct: 66 SQLSHQNIVSMIDVDEEDDCYY--LVMEYIEGPTLSEYIE----SHGPLSVDTAINFTNQ 119 Query: 119 VVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDE--QFVSLYGT 176 ++ G+ H + IVHRDIKP NI+ D K+ DFG A+ L + Q + GT Sbjct: 120 ILDGIKHAHDMRIVHRDIKPQNILI----DSNKTLKIFDFGIAKALSETSLTQTNHVLGT 175 Query: 177 EEYLHPDMYERAVLRKDHQKKYGAT---VDLWSIGVTFYHAATGSLPF 221 +Y P+ Q K AT D++SIG+ Y G PF Sbjct: 176 VQYFSPE-----------QAKGEATDECTDIYSIGIVLYEMLVGEPPF 212 >4E20-A nrPDB Length = 290 Score = 67.8 bits (164), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 54/206 (26%), Positives = 94/206 (45%), Gaps = 16/206 (7%) Query: 15 LGQGATANV----FRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKL 70 LG+G V + + TG++ A+K + RE E+L+ L H++IVK Sbjct: 16 LGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSGWQREIEILRTLYHEHIVKY 75 Query: 71 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 130 E+ + L+ME+ P GSL L P + GL ++ L+ + + GM +L Sbjct: 76 KGCCEDQGEKSVQLVMEYVPLGSLRDYL--PRHCVGL--AQLLLFAQQICEGMAYLHAQH 131 Query: 131 IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVL 190 +HR + N++ D + K+ DFG A+ + + ++ + E+ P + Sbjct: 132 YIHRALAARNVLL----DNDRLVKIGDFGLAKAVPEGHEYYRV--REDGDSPVFWYAPEC 185 Query: 191 RKDHQKKYGATVDLWSIGVTFYHAAT 216 K+ + Y + D+WS GVT Y T Sbjct: 186 LKECKFYYAS--DVWSFGVTLYELLT 209 >4KRC-A nrPDB Length = 317 Score = 67.8 bits (164), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 69/230 (30%), Positives = 98/230 (42%), Gaps = 27/230 (11%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 74 LG G A V++G +K TG A+K S +RE ++K+L H+NIV+L+ + Sbjct: 13 LGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYDVI 72 Query: 75 EETTTRHKVLIMEFCPCG-----SLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN 129 T L+ EF TV P GL + ++ G+ EN Sbjct: 73 H--TENKLTLVFEFMDNDLKKYMDSRTVGNTPR---GLELNLVKYFQWQLLQGLAFCHEN 127 Query: 130 GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELE-DDEQFVSLYGTEEYLHPDMYERA 188 I+HRD+KP N++ I + GQ KL DFG AR F S T Y PD+ + Sbjct: 128 KILHRDLKPQNLL--INKRGQ--LKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGS 183 Query: 189 VLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKII 238 + Y ++D+WS G TG F P N E K+I Sbjct: 184 -------RTYSTSIDIWSCGCILAEMITGKPLF-----PGTNDEEQLKLI 221 >6BXI-A nrPDB Length = 333 Score = 67.4 bits (163), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 63/246 (25%), Positives = 101/246 (41%), Gaps = 55/246 (22%) Query: 14 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDV-QMR-EFEVLKKLNHKNIVKLF 71 ++G+GA V + K TG ++A+K+ L V +R E ++L + + +VK+F Sbjct: 13 VIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADSLWVVKMF 72 Query: 72 AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGI 131 ++ + LIMEF P G + T+L + L E E + + V ++ + + G Sbjct: 73 YSFQDKLNLY--LIMEFLPGGDMMTLLMKKDT---LTEEETQFYIAETVLAIDSIHQLGF 127 Query: 132 VHRDIKPGNIMRVIGEDGQSVYKLTDFGAA----------------RELEDDEQF----- 170 +HRDIKP N++ D + KL+DFG L D F Sbjct: 128 IHRDIKPDNLLL----DSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNS 183 Query: 171 ---------------VSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAA 215 S GT +Y+ P+++ Q Y D WS+GV Y Sbjct: 184 KRKAETWKRNRRQLAFSTVGTPDYIAPEVF--------MQTGYNKLCDWWSLGVIMYEML 235 Query: 216 TGSLPF 221 G PF Sbjct: 236 IGYPPF 241 >1S9I-A nrPDB Length = 354 Score = 67.4 bits (163), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 65/212 (30%), Positives = 101/212 (47%), Gaps = 23/212 (10%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPV--DVQMREFEVLKKLNHKNIVKLFA 72 LG G V + +H+ +G + A K+ + ++P + +RE +VL + N IV + Sbjct: 24 LGAGNGGVVTKVQHRPSGLIMARKLIH--LEIKPAIRNQIIRELQVLHECNSPYIVGFYG 81 Query: 73 IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE-NGI 131 + + ME GSL VL+E A +PE V V+ G+ +LRE + I Sbjct: 82 --AFYSDGEISICMEHMDGGSLDQVLKE---AKRIPEEILGKVSIAVLRGLAYLREKHQI 136 Query: 132 VHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLR 191 +HRD+KP NI+ + G+ KL DFG + +L D S GT Y+ P+ L+ Sbjct: 137 MHRDVKPSNIL--VNSRGE--IKLCDFGVSGQL-IDSMANSFVGTRSYMAPER-----LQ 186 Query: 192 KDHQKKYGATVDLWSIGVTFYHAATGSLPFRP 223 H Y D+WS+G++ A G P P Sbjct: 187 GTH---YSVQSDIWSMGLSLVELAVGRYPIPP 215 >3E3P-A nrPDB Length = 360 Score = 67.0 bits (162), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 69/224 (30%), Positives = 98/224 (43%), Gaps = 35/224 (15%) Query: 14 ILGQGATANVFRGRHKKTGDLFAIK-VFNNISFLRPVDVQMREFEVLKKL---NHKNIVK 69 + GQG V G+ K TG AIK V + F + RE ++++ L +H NIV+ Sbjct: 30 MAGQGTFGTVQLGKEKSTGMSVAIKKVIQDPRF------RNRELQIMQDLAVLHHPNIVQ 83 Query: 70 L---FAIEEETTTRHKVL--IMEFCP------CGSLYTVLEEPSNAYGLPESEFLIVLRD 118 L F E R L +ME+ P C + Y P + FL L Sbjct: 84 LQSYFYTLGERDRRDIYLNVVMEYVPDTLHRCCRNYYRRQVAPP---PILIKVFLFQLIR 140 Query: 119 VVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEE 178 +G + HL + HRDIKP N++ V DG KL DFG+A++L E V+ + Sbjct: 141 SIGCL-HLPSVNVCHRDIKPHNVL-VNEADG--TLKLCDFGSAKKLSPSEPNVAYICSRY 196 Query: 179 YLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFR 222 Y P++ + H Y VD+WS+G F G FR Sbjct: 197 YRAPEL----IFGNQH---YTTAVDIWSVGCIFAEMMLGEPIFR 233 >2F57-A nrPDB Length = 317 Score = 67.0 bits (162), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 55/222 (24%), Positives = 103/222 (46%), Gaps = 23/222 (10%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 74 +G+G+T V K TG A+K + R ++ E +++ +H N+V +++ Sbjct: 53 IGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQR-RELLFNEVVIMRDYHHDNVVDMYS-- 109 Query: 75 EETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHR 134 ++MEF G+L ++ + E + V V+ +++L G++HR Sbjct: 110 SYLVGDELWVVMEFLEGGALTDIVTHTR----MNEEQIATVCLSVLRALSYLHNQGVIHR 165 Query: 135 DIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD-EQFVSLYGTEEYLHPDMYERAVLRKD 193 DIK +I+ + DG+ KL+DFG ++ + + SL GT ++ P++ R Sbjct: 166 DIKSDSIL--LTSDGR--IKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRL----- 216 Query: 194 HQKKYGATVDLWSIGVTFYHAATGSLPF---RPFEGPRRNKE 232 YG VD+WS+G+ G P+ P + RR ++ Sbjct: 217 ---PYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRD 255 >4APC-A nrPDB Length = 350 Score = 67.0 bits (162), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 62/229 (27%), Positives = 101/229 (44%), Gaps = 23/229 (10%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHKNIVKLFA 72 +G+G+ + + G + IK N IS + + + RE VL + H NIV+ Sbjct: 32 IGEGSFGKAILVKSTEDGRQYVIKEIN-ISRMSSKEREESRREVAVLANMKHPNIVQYRE 90 Query: 73 IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIV 132 EE + + ++M++C G L+ + E + L + + H+ + I+ Sbjct: 91 SFEENGSLY--IVMDYCEGGDLFKRINAQKGVL-FQEDQILDWFVQICLALKHVHDRKIL 147 Query: 133 HRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFV-SLYGTEEYLHPDMYERAVLR 191 HRDIK NI + +DG +L DFG AR L + + GT YL P++ E Sbjct: 148 HRDIKSQNIF--LTKDG--TVQLGDFGIARVLNSTVELARACIGTPYYLSPEICE----- 198 Query: 192 KDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITG 240 K Y D+W++G Y T F G +N ++ KII+G Sbjct: 199 ---NKPYNNKSDIWALGCVLYELCTLKHAFE--AGSMKN--LVLKIISG 240 >6HV0-A nrPDB Length = 416 Score = 66.6 bits (161), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 62/218 (28%), Positives = 106/218 (48%), Gaps = 26/218 (11%) Query: 13 DILGQGATAN-VFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLN-HKNIVKL 70 D+LG GA V+RG + SF RE ++L++ + H N+++ Sbjct: 14 DVLGHGAEGTIVYRGMFDNRDVAVKRILPECFSFAD------REVQLLRESDEHPNVIRY 67 Query: 71 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAY-GLPESEFLIVLRDVVGGMNHLREN 129 F E++ ++ + +E C +L +E+ A+ GL E + +L+ G+ HL Sbjct: 68 FCTEKDRQFQY--IAIELC-AATLQEYVEQKDFAHLGL---EPITLLQQTTSGLAHLHSL 121 Query: 130 GIVHRDIKPGNIM-RVIGEDGQSVYKLTDFGAARELEDDEQFVS----LYGTEEYLHPDM 184 IVHRD+KP NI+ + G+ ++DFG ++L S + GTE ++ P+M Sbjct: 122 NIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEM 181 Query: 185 YERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPF 221 L +D ++ TVD++S G FY+ + GS PF Sbjct: 182 -----LSEDCKENPTYTVDIFSAGCVFYYVISEGSHPF 214 >6DBN-A nrPDB Length = 316 Score = 66.6 bits (161), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 58/210 (27%), Positives = 91/210 (43%), Gaps = 22/210 (10%) Query: 15 LGQGATANVFRGRHK----KTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKL 70 LG+G V R+ TG+ A+K S + +E E+L+ L H+NIVK Sbjct: 43 LGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKY 102 Query: 71 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 130 I E LIMEF P GSL L + N L + L + GM++L Sbjct: 103 KGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQ--LKYAVQICKGMDYLGSRQ 160 Query: 131 IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEE----YLHPDMYE 186 VHRD+ N++ + + K+ DFG + +E D+++ ++ + + P+ Sbjct: 161 YVHRDLAARNVLV----ESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECL- 215 Query: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAAT 216 Q K+ D+WS GVT + T Sbjct: 216 -------MQSKFYIASDVWSFGVTLHELLT 238 >3OMV-A nrPDB Length = 307 Score = 66.6 bits (161), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 60/234 (25%), Positives = 103/234 (44%), Gaps = 34/234 (14%) Query: 2 QSTSNHLW-------LLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMR 54 Q S++ W +LS +G G+ V++G K GD+ A+K+ + + P Q + Sbjct: 24 QRDSSYYWEIEASEVMLSTRIGSGSFGTVYKG--KWHGDV-AVKI---LKVVDPTPEQFQ 77 Query: 55 EFE----VLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPES 110 F VL+K H NI+ T + ++ ++C SLY L + + Sbjct: 78 AFRNEVAVLRKTRHVNILLFMGY---MTKDNLAIVTQWCEGSSLYKHLHVQETKFQM--F 132 Query: 111 EFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAA---RELEDD 167 + + + R GM++L I+HRD+K NI +G +V K+ DFG A Sbjct: 133 QLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFL---HEGLTV-KIGDFGLATVKSRWSGS 188 Query: 168 EQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 +Q G+ ++ P+ V+R + D++S G+ Y TG LP+ Sbjct: 189 QQVEQPTGSVLWMAPE-----VIRMQDNNPFSFQSDVYSYGIVLYELMTGELPY 237 >3BBT-B nrPDB Length = 328 Score = 66.6 bits (161), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 58/218 (26%), Positives = 100/218 (45%), Gaps = 22/218 (10%) Query: 14 ILGQGATANVFRGRHKKTGDLF----AIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVK 69 +LG GA V++G G+ AIK+ N + + M E ++ ++H ++V+ Sbjct: 22 VLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVR 81 Query: 70 LFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLI-VLRDVVGGMNHLRE 128 L + T + L+ + P G L + E + G S+ L+ + GM +L E Sbjct: 82 LLGVCLSPTIQ---LVTQLMPHGCLLEYVHEHKDNIG---SQLLLNWCVQIAKGMMYLEE 135 Query: 129 NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERA 188 +VHRD+ N++ + K+TDFG AR LE DE+ + G + + + Sbjct: 136 RRLVHRDLAARNVLV----KSPNHVKITDFGLARLLEGDEKEYNADGGKMPI-----KWM 186 Query: 189 VLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEG 226 L H +K+ D+WS GVT + T +P++G Sbjct: 187 ALECIHYRKFTHQSDVWSYGVTIWELMT--FGGKPYDG 222 >6GU6-A nrPDB Length = 302 Score = 66.2 bits (160), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 60/208 (28%), Positives = 92/208 (44%), Gaps = 24/208 (11%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPV-DVQMREFEVLKKLNHKNIVKLFAI 73 +G+G V++GRHK TG + A+K S V +RE +LK+L H NIV L + Sbjct: 15 IGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDV 74 Query: 74 EEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVH 133 + + + LI EF + P Y + S L ++ G+ ++H Sbjct: 75 LMQDSRLY--LIFEFLSMDLKKYLDSIPPGQY-MDSSLVKSYLYQILQGIVFCHSRRVLH 131 Query: 134 RDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD-----EQFVSLYGTEEYLHPDMYERA 188 RD+KP N++ D + KL DFG AR + V+L+ Y P++ + Sbjct: 132 RDLKPQNLLI----DDKGTIKLADFGLARAFGIPIRVYTHEVVTLW----YRSPEVLLGS 183 Query: 189 VLRKDHQKKYGATVDLWSIGVTFYHAAT 216 +Y VD+WSIG F AT Sbjct: 184 A-------RYSTPVDIWSIGTIFAELAT 204 >4OLI-A nrPDB Length = 645 Score = 66.2 bits (160), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 51/206 (24%), Positives = 97/206 (47%), Gaps = 16/206 (7%) Query: 15 LGQGATANV----FRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKL 70 LG+G V + + TG++ A+K + +E ++L+ L H++I+K Sbjct: 361 LGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKY 420 Query: 71 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 130 E+ + L+ME+ P GSL L P ++ GL ++ L+ + + GM +L Sbjct: 421 KGCCEDQGEKSLQLVMEYVPLGSLRDYL--PRHSIGL--AQLLLFAQQICEGMAYLHSQH 476 Query: 131 IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVL 190 +HR++ N++ D + K+ DFG A+ + + ++ + E+ P + Sbjct: 477 YIHRNLAARNVLL----DNDRLVKIGDFGLAKAVPEGHEYYRV--REDGDSPVFWYAPEC 530 Query: 191 RKDHQKKYGATVDLWSIGVTFYHAAT 216 K+++ Y + D+WS GVT Y T Sbjct: 531 LKEYKFYYAS--DVWSFGVTLYELLT 554 >4RA4-A nrPDB Length = 355 Score = 66.2 bits (160), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 56/211 (26%), Positives = 96/211 (45%), Gaps = 19/211 (9%) Query: 14 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHKNIVKLF 71 +LG+G+ V K T +L+AIK+ ++ DV+ M E VL L+ + Sbjct: 27 VLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQL 86 Query: 72 AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGI 131 +T R +ME+ G L +++ + P++ F ++ G+ L + GI Sbjct: 87 HSCFQTVDR-LYFVMEYVNGGDLMYHIQQ-VGKFKEPQAVFYAA--EISIGLFFLHKRGI 142 Query: 132 VHRDIKPGNIMRVIGEDGQSVYKLTDFGAARE-LEDDEQFVSLYGTEEYLHPDMYERAVL 190 ++RD+K N+M D + K+ DFG +E + D + GT +Y+ P++ Sbjct: 143 IYRDLKLDNVML----DSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAY--- 195 Query: 191 RKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 + YG +VD W+ GV Y G PF Sbjct: 196 -----QPYGKSVDWWAYGVLLYEMLAGQPPF 221 >1UA2-A nrPDB Length = 346 Score = 66.2 bits (160), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 58/216 (26%), Positives = 101/216 (46%), Gaps = 22/216 (10%) Query: 13 DILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVD----VQMREFEVLKKLNHKNIV 68 D LG+G A V++ R K T + AIK D +RE ++L++L+H NI+ Sbjct: 16 DFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNII 75 Query: 69 KLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE 128 L ++ + L+ +F L ++++ N+ L S + + G+ +L + Sbjct: 76 GL--LDAFGHKSNISLVFDFMET-DLEVIIKD--NSLVLTPSHIKAYMLMTLQGLEYLHQ 130 Query: 129 NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAAREL-EDDEQFVSLYGTEEYLHPDMYER 187 + I+HRD+KP N++ + E+G V KL DFG A+ + + T Y P++ Sbjct: 131 HWILHRDLKPNNLL--LDENG--VLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFG 186 Query: 188 AVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRP 223 A + YG VD+W++G +PF P Sbjct: 187 A-------RMYGVGVDMWAVGCILAELLL-RVPFLP 214 >3UIU-A nrPDB Length = 306 Score = 66.2 bits (160), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 59/226 (26%), Positives = 100/226 (44%), Gaps = 49/226 (21%) Query: 13 DILGQGATANVFRGRHKKTGDLFAIK--VFNNISFLRPVDVQMREFEVLKKLNHKNIVKL 70 +++G G VF+ +H+ G + I+ +NN + RE + L KL+H NIV Sbjct: 18 ELIGSGGFGQVFKAKHRIDGKTYVIRRVKYNN-------EKAEREVKALAKLDHVNIVHY 70 Query: 71 ------FAIEEETT-------------------TRHKVLI--MEFCPCGSLYTVLEEPSN 103 F + ET+ ++ K L MEFC G+L +E+ Sbjct: 71 NGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEK-RR 129 Query: 104 AYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARE 163 L + L + + G++++ ++HRD+KP NI V D + V K+ DFG Sbjct: 130 GEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLV---DTKQV-KIGDFGLVTS 185 Query: 164 LEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGV 209 L++D + GT Y+ P+ + YG VDL+++G+ Sbjct: 186 LKNDGKRTRSKGTLRYMSPEQIS--------SQDYGKEVDLYALGL 223 >4PWN-A nrPDB Length = 274 Score = 65.9 bits (159), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 73/261 (27%), Positives = 119/261 (45%), Gaps = 34/261 (13%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMRE-FEVLKKLNHKNIVKLFAI 73 +G+G+ V++G +T A + + + +E E+LK L H NIV+ + Sbjct: 18 IGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQHPNIVRFYDS 77 Query: 74 EEETTTRHK--VLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIV-LRDVVGGMN--HLRE 128 E T K VL+ E G+L T L+ + + + + L R ++ G+ H R Sbjct: 78 WESTVKGKKCIVLVTELMTSGTLKTYLKR----FKVMKIKVLRSWCRQILKGLQFLHTRT 133 Query: 129 NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFV-SLYGTEEYLHPDMYER 187 I+HRD+K NI + G G K+ D G A LE F S+ GT E++ P+MYE Sbjct: 134 PPIIHRDLKCDNIF-ITGPTGS--VKIGDLGLA-TLEKRASFAKSVIGTPEFMAPEMYE- 188 Query: 188 AVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITG--KPSG- 244 +KY +VD+++ G+ AT P+ + N +Y+ +T KP+ Sbjct: 189 --------EKYDESVDVYAFGMCMLEMATSEYPYSECQ----NAAQIYRRVTSGVKPASF 236 Query: 245 ---AISGVQKAENGPIDWSGD 262 AI V++ G I + D Sbjct: 237 DKVAIPEVKEIIEGCIRQNKD 257 >3AOX-A nrPDB Length = 344 Score = 65.9 bits (159), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 58/239 (24%), Positives = 105/239 (43%), Gaps = 28/239 (11%) Query: 15 LGQGATANVFRGR-----HKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVK 69 LG GA V+ G+ + + A+K + + + E ++ K NH+NIV+ Sbjct: 55 LGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVR 114 Query: 70 LFAIEEETTTRHKVLIMEFCPCGSLYTVLEE----PSNAYGLPESEFLIVLRDVVGGMNH 125 + ++ R +++E G L + L E PS L + L V RD+ G + Sbjct: 115 CIGVSLQSLPR--FILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQY 172 Query: 126 LRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQF----VSLYGTEEYLH 181 L EN +HRDI N + G+ V K+ DFG AR++ + ++ +++ Sbjct: 173 LEENHFIHRDIAARNCLLTCPGPGR-VAKIGDFGMARDIYRASYYRKGGCAMLPV-KWMP 230 Query: 182 PDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITG 240 P+ + + + + D WS GV + SL + P+ + N+EV+ + +G Sbjct: 231 PEAFMEGI--------FTSKTDTWSFGVLLWEIF--SLGYMPYPS-KSNQEVLEFVTSG 278 >5HIE-A nrPDB Length = 302 Score = 65.5 bits (158), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 58/212 (27%), Positives = 95/212 (44%), Gaps = 28/212 (13%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQM--REFEVLKKLNHKNIVKLFA 72 +G G+ V++G K GD+ A+K+ L P +Q E VL+K H NI+ Sbjct: 44 IGSGSFGTVYKG--KWHGDV-AVKM------LTPQQLQAFKNEVGVLRKTRHVNILLFMG 94 Query: 73 IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIV 132 +T ++ ++C SLY L + + + + + R GM++L I+ Sbjct: 95 Y---STKPQLAIVTQWCEGSSLYHHLHIIETKFEM--IKLIDIARQTAQGMDYLHAKSII 149 Query: 133 HRDIKPGNIMRVIGEDGQSVYKLTDFGAA---RELEDDEQFVSLYGTEEYLHPDMYERAV 189 HRD+K NI + ED K+ DFG A QF L G+ ++ P+ V Sbjct: 150 HRDLKSNNIF--LHED--LTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPE-----V 200 Query: 190 LRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 +R + Y D+++ G+ Y TG LP+ Sbjct: 201 IRMQDKNPYSFQSDVYAFGIVLYELMTGQLPY 232 >4QNY-A nrPDB Length = 354 Score = 65.5 bits (158), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 66/243 (27%), Positives = 107/243 (44%), Gaps = 26/243 (10%) Query: 9 WLLSDILGQGATANVFRGRHKKTGD-LFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHK 65 +LL I+G G+ V R R K+ + L A+K N F + + +RE ++L N Sbjct: 22 YLLERIIGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEEVILAKRILREIKLLAHFNDD 81 Query: 66 NIVKLFAI---EEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGG 122 NI+ L I E+ H ++M+ L VL + L E+ + + Sbjct: 82 NIIGLRNILTPEDPENFDHFYIVMDIMET-DLKQVLR---SGQELTEAHIQFFIYQALRA 137 Query: 123 MNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEE-YLH 181 ++ + G++HRDI P NI+ D K+ DFG A+E D ++++ Y T Y Sbjct: 138 LHIIHSAGVIHRDITPANILVNTNCD----LKICDFGLAKEENDQGEYMTDYVTMRWYRA 193 Query: 182 PDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKI-ITG 240 P++ K Y A +D+W IG GS P F+G R ++ + + G Sbjct: 194 PELVM-------EDKDYSAQIDVWGIGCIL-GELLGSRPL--FQGKDRVNQLDKIVDVIG 243 Query: 241 KPS 243 PS Sbjct: 244 TPS 246 >3PLS-A nrPDB Length = 298 Score = 65.5 bits (158), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 60/221 (27%), Positives = 96/221 (43%), Gaps = 21/221 (9%) Query: 14 ILGQGATANVFRGRHKKTGD---LFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKL 70 ++G+G V+ G + AIK + I+ ++ V+ +RE +++ LNH N++ L Sbjct: 28 VIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLNHPNVLAL 87 Query: 71 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVL-RDVVGGMNHLREN 129 I VL+ C G L + P P + LI V GM +L E Sbjct: 88 IGIMLPPEGLPHVLLPYMC-HGDLLQFIRSPQRN---PTVKDLISFGLQVARGMEYLAEQ 143 Query: 130 GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDM-YERA 188 VHRD+ N M D K+ DFG AR++ D E Y +++ H + + Sbjct: 144 KFVHRDLAARNCML----DESFTVKVADFGLARDILDRE----YYSVQQHRHARLPVKWT 195 Query: 189 VLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFR---PFE 225 L ++ D+WS GV + T G+ P+R PF+ Sbjct: 196 ALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFD 236 >3PPZ-A nrPDB Length = 309 Score = 65.5 bits (158), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 64/211 (30%), Positives = 98/211 (46%), Gaps = 20/211 (9%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISF-LRPVDVQMREFEVLKKLNHKNIVKLFAI 73 +G G+ V R G A+K+ F V+ +RE ++K+L H NIV LF + Sbjct: 45 IGAGSFGTVHRAEWH--GSDVAVKILMEQDFHAERVNEFLREVAIMKRLRHPNIV-LF-M 100 Query: 74 EEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL--RENGI 131 T + ++ E+ GSLY +L + L E L + DV GMN+L R I Sbjct: 101 GAVTQPPNLSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGMNYLHNRNPPI 160 Query: 132 VHRDIKPGNIMRVIGEDGQSVYKLTDFGAAR-ELEDDEQFVSLYGTEEYLHPDMYERAVL 190 VHRD+K N++ D + K+ DFG +R + S GT E++ P+ VL Sbjct: 161 VHRDLKSPNLL----VDKKYTVKVCDFGLSRLKASTFLSSKSAAGTPEWMAPE-----VL 211 Query: 191 RKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 R + + D++S GV + AT P+ Sbjct: 212 RDEPSNEKS---DVYSFGVILWELATLQQPW 239 >4MYG-A nrPDB Length = 372 Score = 65.1 bits (157), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 58/218 (26%), Positives = 99/218 (45%), Gaps = 34/218 (15%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQM------REFEVLKKLNHKNIV 68 +G GA +V K++G+ AIK + RP ++ RE +LK + H+N++ Sbjct: 51 VGSGAYGSVCSAIDKRSGEKVAIKKLS-----RPFQSEIFAKRAYRELLLLKHMQHENVI 105 Query: 69 KLFAIEEETTTRHKV----LIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 124 L + ++ L+M F + T L++ E + ++ ++ G+ Sbjct: 106 GLLDVFTPASSLRNFYDFYLVMPF-----MQTDLQK-IMGMEFSEEKIQYLVYQMLKGLK 159 Query: 125 HLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDM 184 ++ G+VHRD+KPGN+ + ED + K+ DFG AR D + T Y P++ Sbjct: 160 YIHSAGVVHRDLKPGNL--AVNEDCE--LKILDFGLARHA--DAEMTGYVVTRWYRAPEV 213 Query: 185 YERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFR 222 +L H Y TVD+WS+G TG F+ Sbjct: 214 ----ILSWMH---YNQTVDIWSVGCIMAEMLTGKTLFK 244 >1TKI-A nrPDB Length = 321 Score = 65.1 bits (157), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 54/213 (25%), Positives = 96/213 (45%), Gaps = 16/213 (7%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIV 68 +++++ LG+G V R + + K F + V V+ +E +L H+NI+ Sbjct: 7 YMIAEDLGRGEFGIVHRCVETSSKKTYMAK-FVKVKGTDQVLVK-KEISILNIARHRNIL 64 Query: 69 KLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE 128 L E + V+I EF ++ + ++A+ L E E + + V + L Sbjct: 65 HLH--ESFESMEELVMIFEFISGLDIFERIN--TSAFELNEREIVSYVHQVCEALQFLHS 120 Query: 129 NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERA 188 + I H DI+P NI + S K+ +FG AR+L+ + F L+ EY P++++ Sbjct: 121 HNIGHFDIRPENI--IYQTRRSSTIKIIEFGQARQLKPGDNFRLLFTAPEYYAPEVHQHD 178 Query: 189 VLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 V+ D+WS+G Y +G PF Sbjct: 179 VV--------STATDMWSLGTLVYVLLSGINPF 203 >5L6P-A nrPDB Length = 298 Score = 65.1 bits (157), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 60/226 (26%), Positives = 104/226 (46%), Gaps = 36/226 (15%) Query: 11 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRP--VDVQMREF----EVLKKLNH 64 + +++G G V RGR K+ G +VF I L+ + Q R+F ++ + +H Sbjct: 23 IEEVIGAGEFGEVCRGRLKQPGRR---EVFVAIKTLKVGYTERQRRDFLSEASIMGQFDH 79 Query: 65 KNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIV-----LRDV 119 NI++L + T +R +++ EF +L + L L + +F ++ LR + Sbjct: 80 PNIIRLEGVV--TKSRPVMILTEFMENCALDSFLR-------LNDGQFTVIQLVGMLRGI 130 Query: 120 VGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQ---FVSLYGT 176 GM +L E VHRD+ NI+ + V K++DFG +R LEDD + S G Sbjct: 131 AAGMKYLSEMNYVHRDLAARNIL----VNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGG 186 Query: 177 EEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPF 221 + + E R K+ + D+WS G+ + + G P+ Sbjct: 187 KIPIRWTAPEAIAYR-----KFTSASDVWSYGIVMWEVMSYGERPY 227 >2W1I-A nrPDB Length = 326 Score = 65.1 bits (157), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 61/219 (27%), Positives = 97/219 (44%), Gaps = 16/219 (7%) Query: 2 QSTSNHLWLLSDILGQGATANVFRGRHK----KTGDLFAIKVFNNISFLRPVDVQMREFE 57 Q HL L LG+G +V R+ TG++ A+K + + D + RE E Sbjct: 37 QFEERHLKFLQQ-LGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFE-REIE 94 Query: 58 VLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLR 117 +LK L H NIVK + R+ LIME+ P GSL L++ + + L Sbjct: 95 ILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKER--IDHIKLLQYTS 152 Query: 118 DVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTE 177 + GM +L +HRD+ NI+ + ++ K+ DFG + L D+++ Y + Sbjct: 153 QICKGMEYLGTKRYIHRDLATRNILV----ENENRVKIGDFGLTKVLPQDKEY---YKVK 205 Query: 178 EYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT 216 E ++ A + K+ D+WS GV Y T Sbjct: 206 EPGESPIFWYAP-ESLTESKFSVASDVWSFGVVLYELFT 243 >3IO7-A nrPDB Length = 313 Score = 65.1 bits (157), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 61/219 (27%), Positives = 97/219 (44%), Gaps = 16/219 (7%) Query: 2 QSTSNHLWLLSDILGQGATANVFRGRHK----KTGDLFAIKVFNNISFLRPVDVQMREFE 57 Q HL L LG+G +V R+ TG++ A+K + + D + RE E Sbjct: 24 QFEERHLKFLQQ-LGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFE-REIE 81 Query: 58 VLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLR 117 +LK L H NIVK + R+ LIME+ P GSL L++ + + L Sbjct: 82 ILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKER--IDHIKLLQYTS 139 Query: 118 DVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTE 177 + GM +L +HRD+ NI+ + ++ K+ DFG + L D+++ Y + Sbjct: 140 QICKGMEYLGTKRYIHRDLATRNIL----VENENRVKIGDFGLTKVLPQDKEY---YKVK 192 Query: 178 EYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT 216 E ++ A + K+ D+WS GV Y T Sbjct: 193 EPGESPIFWYAP-ESLTESKFSVASDVWSFGVVLYELFT 230 >3KUL-B nrPDB Length = 325 Score = 64.7 bits (156), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 58/213 (27%), Positives = 95/213 (44%), Gaps = 18/213 (8%) Query: 14 ILGQGATANVFRGRHKKTGDL---FAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKL 70 I+G G + V GR + G AIK R + E ++ + +H NI++L Sbjct: 56 IIGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGYTERQRRDFLSEASIMGQFDHPNIIRL 115 Query: 71 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 130 + T R +++ E+ GSL T L + + + + +LR V GM +L + G Sbjct: 116 EGVV--TRGRLAMIVTEYMENGSLDTFLRTHDGQFTI--MQLVGMLRGVGAGMRYLSDLG 171 Query: 131 IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD-EQFVSLYGTEEYLHPDMYERAV 189 VHRD+ N++ D V K++DFG +R LEDD + + G + + E Sbjct: 172 YVHRDLAARNVL----VDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTAPEAIA 227 Query: 190 LRKDHQKKYGATVDLWSIGVTFYHA-ATGSLPF 221 R + + D+WS GV + A G P+ Sbjct: 228 FR-----TFSSASDVWSFGVVMWEVLAYGERPY 255 >5MJB-A nrPDB Length = 305 Score = 64.7 bits (156), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 55/221 (24%), Positives = 105/221 (47%), Gaps = 26/221 (11%) Query: 11 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRP--VDVQMREF----EVLKKLNH 64 + +++G G V++GR K G +++ I L+ + Q R+F ++ + +H Sbjct: 30 IEEVIGAGEFGEVYKGRLKLPGKR---EIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDH 86 Query: 65 KNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 124 +NI++L + T +R ++I EF +L + L + + + + + +LR + GM Sbjct: 87 RNIIRLEGVV--TKSRPVMIITEFMENCALDSFLRQNDGQFTV--IQLVGMLRGIAAGMK 142 Query: 125 HLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQ---FVSLYGTEEYLH 181 +L E VHRD+ NI+ + V K++DFG +R L+DD + S G + + Sbjct: 143 YLSEMNYVHRDLAARNIL----VNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVR 198 Query: 182 PDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPF 221 E R K+ + D+WS G+ + + G P+ Sbjct: 199 WTAPEAIAYR-----KFTSASDVWSYGIVMWEVMSFGERPY 234 >5LOH-A nrPDB Length = 341 Score = 64.7 bits (156), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 61/217 (28%), Positives = 107/217 (49%), Gaps = 30/217 (13%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFL-RPVDVQMR-EFEVLKKLNHKNIVKLFA 72 + +GA V+ G+ K G L+A+KV + + + Q++ E + L IV L+ Sbjct: 44 ISRGAFGKVYLGQ--KGGKLYAVKVVKKADMINKNMTHQVQAERDALALSKSPFIVHLYY 101 Query: 73 IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLI-VLRDVVGGMNHLRENGI 131 + + L+ME+ G + ++L + YG + E + + +V +++L +GI Sbjct: 102 SLQSANNVY--LVMEYLIGGDVKSLL----HIYGYFDEEMAVKYISEVALALDYLHRHGI 155 Query: 132 VHRDIKPGNIMRVIGEDGQSVYKLTDFGAAR-ELEDDEQFVSLY------GTEEYLHPDM 184 +HRD+KP N++ I +G KLTDFG ++ L D + + GT +YL P++ Sbjct: 156 IHRDLKPDNML--ISNEGH--IKLTDFGLSKVTLNRDINMMDILTTRTFCGTPDYLAPEL 211 Query: 185 YERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 +L + H G VD W++GV + TG PF Sbjct: 212 ----LLGRAH----GPAVDWWALGVCLFEFLTGIPPF 240 >4AU8-A nrPDB Length = 296 Score = 64.3 bits (155), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 63/217 (29%), Positives = 97/217 (44%), Gaps = 30/217 (13%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKV--FNNISFLRPVDVQMREFEVLKKLNHKNIVKLFA 72 +G+G VF+ ++++T ++ A+K ++ P +RE +LK+L HKNIV+L Sbjct: 14 IGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSA-LREICLLKELKHKNIVRLHD 72 Query: 73 IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPE--SEFLIVLRDVVGGMNHLRENG 130 + + + L+ EFC L + N PE FL L + G+ Sbjct: 73 VLH--SDKKLTLVFEFCD-QDLKKYFDS-CNGDLDPEIVKSFLFQL---LKGLGFCHSRN 125 Query: 131 IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEE----YLHPDMYE 186 ++HRD+KP N++ I +G+ KL DFG AR V Y E Y PD+ Sbjct: 126 VLHRDLKPQNLL--INRNGE--LKLADFGLARAFGIP---VRCYSAEVVTLWYRPPDVLF 178 Query: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRP 223 A K Y ++D+WS G F A P P Sbjct: 179 GA-------KLYSTSIDMWSAGCIFAELANAGRPLFP 208 >6F3F-A nrPDB Length = 455 Score = 64.3 bits (155), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 59/213 (27%), Positives = 105/213 (49%), Gaps = 28/213 (13%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 74 LGQG V+ G T + AIK + + P + ++E +V+KKL H+ +V+L+A+ Sbjct: 195 LGQGCFGEVWMGTWNGTTRV-AIKTLKPGT-MSP-EAFLQEAQVMKKLRHEKLVQLYAVV 251 Query: 75 EETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHR 134 E ++ E+ GSL L+ + Y L + + + + GM ++ VHR Sbjct: 252 SEEPI---YIVTEYMNKGSLLDFLKGETGKY-LRLPQLVDMSAQIASGMAYVERMNYVHR 307 Query: 135 DIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTE---EYLHPD--MYERAV 189 D++ NI+ +GE+ V K+ DFG AR +ED+E + + G + ++ P+ +Y R Sbjct: 308 DLRAANIL--VGEN--LVCKVADFGLARLIEDNE-YTARQGAKFPIKWTAPEAALYGRFT 362 Query: 190 LRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPF 221 ++ D+WS G+ T G +P+ Sbjct: 363 IKS----------DVWSFGILLTELTTKGRVPY 385 >4E93-A nrPDB Length = 377 Score = 64.3 bits (155), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 54/217 (24%), Positives = 97/217 (44%), Gaps = 22/217 (10%) Query: 10 LLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ---MREFEVLKKLNHKN 66 +L + +G+G VF GR + L A+K P D++ ++E +LK+ +H N Sbjct: 117 VLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRET---LPPDLKAKFLQEARILKQYSHPN 173 Query: 67 IVKLFAIEEETTTRHKV-LIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 125 IV+L + T + + ++ME G T L + L L ++ D GM + Sbjct: 174 IVRLIGV---CTQKQPIYIVMELVQGGDFLTFLR--TEGARLRVKTLLQMVGDAAAGMEY 228 Query: 126 LRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMY 185 L +HRD+ N + + E ++V K++DFG +RE D +Y L Sbjct: 229 LESKCCIHRDLAARNCL--VTE--KNVLKISDFGMSREEAD-----GVYAASGGLRQVPV 279 Query: 186 ERAVLRKDHQKKYGATVDLWSIGVTFYHA-ATGSLPF 221 + + +Y + D+WS G+ + + G+ P+ Sbjct: 280 KWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPY 316 >2H8H-A nrPDB Length = 535 Score = 64.3 bits (155), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 59/213 (27%), Positives = 105/213 (49%), Gaps = 28/213 (13%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 74 LGQG V+ G T + AIK + + P + ++E +V+KKL H+ +V+L+A+ Sbjct: 275 LGQGCFGEVWMGTWNGTTRV-AIKTLKPGT-MSP-EAFLQEAQVMKKLRHEKLVQLYAVV 331 Query: 75 EETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHR 134 E ++ E+ GSL L+ + Y L + + + + GM ++ VHR Sbjct: 332 SEEPI---YIVTEYMSKGSLLDFLKGETGKY-LRLPQLVDMAAQIASGMAYVERMNYVHR 387 Query: 135 DIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTE---EYLHPD--MYERAV 189 D++ NI+ +GE+ V K+ DFG AR +ED+E + + G + ++ P+ +Y R Sbjct: 388 DLRAANIL--VGEN--LVCKVADFGLARLIEDNE-YTARQGAKFPIKWTAPEAALYGRFT 442 Query: 190 LRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPF 221 ++ D+WS G+ T G +P+ Sbjct: 443 IKS----------DVWSFGILLTELTTKGRVPY 465 >2I0E-A nrPDB Length = 353 Score = 63.9 bits (154), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 52/217 (23%), Positives = 92/217 (42%), Gaps = 31/217 (14%) Query: 14 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAI 73 +LG+G+ V K T +L+A+K+ DV +++ +V + K ++ L Sbjct: 27 VLGKGSFGKVMLSERKGTDELYAVKILKK-------DVVIQDDDVECTMVEKRVLALPGK 79 Query: 74 EEETTTRHKVL--------IMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 125 T H +ME+ G L +++ E + ++ G+ Sbjct: 80 PPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR---FKEPHAVFYAAEIAIGLFF 136 Query: 126 LRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARE-LEDDEQFVSLYGTEEYLHPDM 184 L+ GI++RD+K N+M D + K+ DFG +E + D + GT +Y+ P++ Sbjct: 137 LQSKGIIYRDLKLDNVML----DSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEI 192 Query: 185 YERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 + YG +VD W+ GV Y G PF Sbjct: 193 IA--------YQPYGKSVDWWAFGVLLYEMLAGQAPF 221 >2Q0N-A nrPDB Length = 301 Score = 63.9 bits (154), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 51/208 (24%), Positives = 97/208 (46%), Gaps = 20/208 (9%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 74 +G+G+T V + +G L A+K + R ++ E +++ H+N+V+++ Sbjct: 37 IGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQR-RELLFNEVVIMRDYQHENVVEMY--N 93 Query: 75 EETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHR 134 ++MEF G+L ++ + E + V V+ ++ L G++HR Sbjct: 94 SYLVGDELWVVMEFLEGGALTDIVTHTR----MNEEQIAAVCLAVLQALSVLHAQGVIHR 149 Query: 135 DIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD-EQFVSLYGTEEYLHPDMYERAVLRKD 193 DIK +I+ + DG+ KL+DFG ++ + + SL GT ++ P++ R Sbjct: 150 DIKSDSIL--LTHDGR--VKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRL----- 200 Query: 194 HQKKYGATVDLWSIGVTFYHAATGSLPF 221 YG VD+WS+G+ G P+ Sbjct: 201 ---PYGPEVDIWSLGIMVIEMVDGEPPY 225 >4XBR-A nrPDB Length = 366 Score = 63.9 bits (154), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 51/208 (24%), Positives = 97/208 (46%), Gaps = 20/208 (9%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 74 +G+G+T V + +G L A+K + R ++ E +++ H+N+V+++ Sbjct: 102 IGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQR-RELLFNEVVIMRDYQHENVVEMY--N 158 Query: 75 EETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHR 134 ++MEF G+L ++ + E + V V+ ++ L G++HR Sbjct: 159 SYLVGDELWVVMEFLEGGALTDIVTHTR----MNEEQIAAVCLAVLQALSVLHAQGVIHR 214 Query: 135 DIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD-EQFVSLYGTEEYLHPDMYERAVLRKD 193 DIK +I+ + DG+ KL+DFG ++ + + SL GT ++ P++ R Sbjct: 215 DIKSDSIL--LTHDGR--VKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRL----- 265 Query: 194 HQKKYGATVDLWSIGVTFYHAATGSLPF 221 YG VD+WS+G+ G P+ Sbjct: 266 ---PYGPEVDIWSLGIMVIEMVDGEPPY 290 >3PFQ-A nrPDB Length = 674 Score = 63.5 bits (153), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 53/217 (24%), Positives = 94/217 (43%), Gaps = 31/217 (14%) Query: 14 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAI 73 +LG+G+ V K T +L+A+K+ DV +++ +V + K ++ L Sbjct: 348 VLGKGSFGKVMLSERKGTDELYAVKILKK-------DVVIQDDDVECTMVEKRVLALPGK 400 Query: 74 EEETTTRHKVL--------IMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 125 T H +ME+ G L +++ + P + F ++ G+ Sbjct: 401 PPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQ-VGRFKEPHAVFYAA--EIAIGLFF 457 Query: 126 LRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARE-LEDDEQFVSLYGTEEYLHPDM 184 L+ GI++RD+K N+M D + K+ DFG +E + D + GT +Y+ P++ Sbjct: 458 LQSKGIIYRDLKLDNVML----DSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEI 513 Query: 185 YERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 + YG +VD W+ GV Y G PF Sbjct: 514 IA--------YQPYGKSVDWWAFGVLLYEMLAGQAPF 542 >2BPM-A nrPDB Length = 309 Score = 63.5 bits (153), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 62/209 (29%), Positives = 96/209 (45%), Gaps = 27/209 (12%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPV-DVQMREFEVLKKLNHKNIVKLFAI 73 +G+G V++ R+K TG++ A+K + V +RE +LK+LNH NIVKL + Sbjct: 15 IGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDV 74 Query: 74 EEETTTRHKV-LIMEFCPCGSLYTVLE---EPSNAYGLPESEFLIVLRDVVGGMNHLREN 129 T +K+ L+ EF L+ L+ + S G+P L ++ G+ + Sbjct: 75 ---IHTENKLYLVFEF-----LHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 126 Query: 130 GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHP--DMYER 187 ++HRD+KP N++ I +G KL DFG AR Y H ++ R Sbjct: 127 RVLHRDLKPQNLL--INTEG--AIKLADFGLARAFG--------VPVRTYTHEVVTLWYR 174 Query: 188 AVLRKDHQKKYGATVDLWSIGVTFYHAAT 216 A K Y VD+WS+G F T Sbjct: 175 APEILLGCKYYSTAVDIWSLGCIFAEMVT 203 >4FIE-A nrPDB Length = 423 Score = 63.5 bits (153), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 51/208 (24%), Positives = 97/208 (46%), Gaps = 20/208 (9%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 74 +G+G+T V + +G L A+K + R ++ E +++ H+N+V+++ Sbjct: 159 IGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQR-RELLFNEVVIMRDYQHENVVEMY--N 215 Query: 75 EETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHR 134 ++MEF G+L ++ + E + V V+ ++ L G++HR Sbjct: 216 SYLVGDELWVVMEFLEGGALTDIVTH----TRMNEEQIAAVCLAVLQALSVLHAQGVIHR 271 Query: 135 DIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD-EQFVSLYGTEEYLHPDMYERAVLRKD 193 DIK +I+ + DG+ KL+DFG ++ + + SL GT ++ P++ R Sbjct: 272 DIKSDSIL--LTHDGR--VKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRL----- 322 Query: 194 HQKKYGATVDLWSIGVTFYHAATGSLPF 221 YG VD+WS+G+ G P+ Sbjct: 323 ---PYGPEVDIWSLGIMVIEMVDGEPPY 347 >4TNB-A nrPDB Length = 590 Score = 63.2 bits (152), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 54/228 (23%), Positives = 101/228 (44%), Gaps = 19/228 (8%) Query: 14 ILGQGATANVFRGRHKKTGDLFAIKVF--NNISFLRPVDVQMREFEVLKKLNHKNIVKL- 70 +LG+G V + + TG ++A K I + + + E ++L+K+N + +V L Sbjct: 191 VLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLA 250 Query: 71 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 130 +A E T L++ G L + N G E L +++ G+ L Sbjct: 251 YAYE---TKDALCLVLTIMNGGDLKFHIYNMGNP-GFEEERALFYAAEILCGLEDLHHEN 306 Query: 131 IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVL 190 V+RD+KP NI+ D +++D G A ++ + + GT Y+ P++ Sbjct: 307 TVYRDLKPENILL----DDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVL----- 357 Query: 191 RKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKII 238 + ++YG + D W +G Y G PFR + + +EV +++ Sbjct: 358 ---NNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVL 402 >3MN3-A nrPDB Length = 271 Score = 63.2 bits (152), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 53/210 (25%), Positives = 92/210 (43%), Gaps = 21/210 (10%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMR---EFEVLKKLNHKNIVKLF 71 LG+G+ V H TG A+K+ N L D+Q R E L+ L H +I+KL+ Sbjct: 12 LGEGSFGKVKLAYHTTTGQKVALKIINK-KVLAKSDMQGRIEREISYLRLLRHPHIIKLY 70 Query: 72 AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGI 131 + + + ++++E+ L+ + + + E E + ++ + + + I Sbjct: 71 DVIK--SKDEIIMVIEYA-GNELFDYIVQRDK---MSEQEARRFFQQIISAVEYCHRHKI 124 Query: 132 VHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLR 191 VHRD+KP N++ D K+ DFG + + D + G+ Y P++ + Sbjct: 125 VHRDLKPENLLL----DEHLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKLYA 180 Query: 192 KDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 G VD+WS GV Y LPF Sbjct: 181 -------GPEVDVWSCGVILYVMLCRRLPF 203 >4CRS-A nrPDB Length = 341 Score = 63.2 bits (152), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 60/214 (28%), Positives = 96/214 (44%), Gaps = 24/214 (11%) Query: 14 ILGQGATANVFRGRHKKTGDLFAIKVF--NNISFLRPVDVQM---REFEVLKKLNHKNIV 68 +L +G V +K T ++FAIK +I VD M R FE + + H +V Sbjct: 19 VLLRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLV 78 Query: 69 KLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE 128 LFA + T H +ME+ G L + ++ + P + F VV G+ +L E Sbjct: 79 NLFACFQ--TKEHVCFVMEYAAGGDLMMHIH--TDVFSEPRAVFYAAC--VVLGLQYLHE 132 Query: 129 NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARE-LEDDEQFVSLYGTEEYLHPDMYER 187 + IV+RD+K N++ + K+ DFG +E + ++ + GT E+L P++ Sbjct: 133 HKIVYRDLKLDNLLLDT----EGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLT- 187 Query: 188 AVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 + Y VD W +GV Y G PF Sbjct: 188 -------ETSYTRAVDWWGLGVLIYEMLVGESPF 214 >4JDH-A nrPDB Length = 346 Score = 63.2 bits (152), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 51/208 (24%), Positives = 97/208 (46%), Gaps = 20/208 (9%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 74 +G+G+T V + +G L A+K + R ++ E +++ H+N+V+++ Sbjct: 82 IGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQR-RELLFNEVVIMRDYQHENVVEMY--N 138 Query: 75 EETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHR 134 ++MEF G+L ++ + E + V V+ ++ L G++HR Sbjct: 139 SYLVGDELWVVMEFLEGGALTDIVTHTR----MNEEQIAAVCLAVLQALSVLHAQGVIHR 194 Query: 135 DIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD-EQFVSLYGTEEYLHPDMYERAVLRKD 193 DIK +I+ + DG+ KL+DFG ++ + + SL GT ++ P++ R Sbjct: 195 DIKSDSIL--LTHDGR--VKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRL----- 245 Query: 194 HQKKYGATVDLWSIGVTFYHAATGSLPF 221 YG VD+WS+G+ G P+ Sbjct: 246 ---PYGPEVDIWSLGIMVIEMVDGEPPY 270 >4PL5-B nrPDB Length = 435 Score = 62.8 bits (151), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 59/218 (27%), Positives = 103/218 (47%), Gaps = 26/218 (11%) Query: 13 DILGQGATANVFRGRHKKTGDLFAIKVFNN-ISFLRPVDVQMREFEVLKKLN-HKNIVKL 70 D+LG GA + D+ ++ SF RE ++L++ + H N+++ Sbjct: 33 DVLGHGAEGTIVYKGMFDNRDVAVKRILPECFSFAD------REVQLLRESDEHPNVIRY 86 Query: 71 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAY-GLPESEFLIVLRDVVGGMNHLREN 129 F E++ ++ + +E C +L +E+ A+ GL E + +L G+ HL Sbjct: 87 FCTEKDRQFQY--IAIELC-AATLQEYVEQKDFAHLGL---EPITLLHQTTSGLAHLHSL 140 Query: 130 GIVHRDIKPGNI-MRVIGEDGQSVYKLTDFGAARELEDDEQFVS----LYGTEEYLHPDM 184 IVHRD+KP NI + + G+ ++DFG ++L S + GTE ++ P+M Sbjct: 141 NIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEM 200 Query: 185 YERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPF 221 L +D + TVD++S G FY+ + G PF Sbjct: 201 -----LSEDCKDNPTYTVDIFSAGCVFYYVISEGYHPF 233 >1ZXE-A nrPDB Length = 303 Score = 62.4 bits (150), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 51/225 (22%), Positives = 95/225 (42%), Gaps = 41/225 (18%) Query: 14 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFA- 72 +LGQGA V + R+ +AIK + + + E +L LNH+ +V+ +A Sbjct: 13 VLGQGAFGQVVKARNALDSRYYAIKKIRHTE--EKLSTILSEVMLLASLNHQYVVRYYAA 70 Query: 73 -------IEEETTTRHKVLI---MEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGG 122 ++ T + K + ME+C +LY ++ S E+ + R ++ Sbjct: 71 WLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIH--SENLNQQRDEYWRLFRQILEA 128 Query: 123 MNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELE---------------DD 167 ++++ GI+HR++KP NI D K+ DFG A+ + Sbjct: 129 LSYIHSQGIIHRNLKPMNIFI----DESRNVKIGDFGLAKNVHRSLDILKLDSQNLPGSS 184 Query: 168 EQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFY 212 + S GT Y+ ++ D Y +D++S+G+ F+ Sbjct: 185 DNLTSAIGTAMYVATEVL-------DGTGHYNEKIDMYSLGIIFF 222 >6CKI-A nrPDB Length = 316 Score = 62.4 bits (150), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 62/224 (27%), Positives = 105/224 (46%), Gaps = 25/224 (11%) Query: 10 LLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKL----NHK 65 L D+LG+GA A V + T +A+K+ +P ++ R F ++ L H+ Sbjct: 16 LQEDVLGEGAHARVQTCINLITSQEYAVKIIEK----QPGHIRSRVFREVEMLYQCQGHR 71 Query: 66 NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 125 N+++L EE + L+ E GS+ + + + + E E +V++DV ++ Sbjct: 72 NVLELIEFFEEEDRFY--LVFEKMRGGSILSHIHKRRH---FNELEASVVVQDVASALDF 126 Query: 126 LRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDF--GAARELEDD------EQFVSLYGTE 177 L GI HRD+KP NI+ + S K+ DF G+ +L D + ++ G+ Sbjct: 127 LHNKGIAHRDLKPENIL-CEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPELLTPCGSA 185 Query: 178 EYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 EY+ P++ E + Y DLWS+GV Y +G PF Sbjct: 186 EYMAPEVVEAF---SEEASIYDKRCDLWSLGVILYILLSGYPPF 226 >5SYS-A nrPDB Length = 286 Score = 62.4 bits (150), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 57/208 (27%), Positives = 100/208 (48%), Gaps = 18/208 (8%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 74 LGQG + G T + AIK + + P + ++E +V+KKL H+ +V+L+A+ Sbjct: 26 LGQGCFGECWMGTWNGTTRV-AIKTLKPGT-MSP-EAFLQEAQVMKKLRHEKLVQLYAVV 82 Query: 75 EETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHR 134 E ++ E+ GSL L+ Y L + + + + GM ++ VHR Sbjct: 83 SEEPI---YIVTEYMSKGSLLDFLKGEMGKY-LRLPQLVDMAAQIASGMAYVERMNYVHR 138 Query: 135 DIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDH 194 D++ NI+ +GE+ V K+ DFG AR +ED+E + + G + + E A+ Sbjct: 139 DLRAANIL--VGEN--LVCKVADFGLARLIEDNE-YTARQGAKFPIKWTAPEAALY---- 189 Query: 195 QKKYGATVDLWSIGVTFYHAAT-GSLPF 221 ++ D+WS G+ T G +P+ Sbjct: 190 -GRFTIKSDVWSFGILLTELTTKGRVPY 216 >3GC9-A nrPDB Length = 370 Score = 62.4 bits (150), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 62/246 (25%), Positives = 107/246 (43%), Gaps = 28/246 (11%) Query: 54 REFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSN----AYGLPE 109 RE +LK L H+N++ L + T+ I +F + T++ N + L + Sbjct: 76 RELRLLKHLKHENVIGLLDVFTPATS-----IEDFSEVYLVTTLMGADLNNIVKSQALSD 130 Query: 110 SEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQ 169 ++ ++ G+ ++ GI+HRD+KP N+ + ED + ++ DFG AR+ DE+ Sbjct: 131 EHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNV--AVNEDSE--LRILDFGLARQA--DEE 184 Query: 170 FVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRR 229 T Y P++ +L H Y TVD+WS+G G F + + Sbjct: 185 MTGYVATRWYRAPEI----MLNWMH---YNQTVDIWSVGCIMAELLQGKALFPGSDYIDQ 237 Query: 230 NKEVMYKIITGKPSGAISGVQKAENGP--IDWSGDMPVS--CSLSRGLQVLLTPVLANIL 285 K +M + G PS + +E+ I MP S+ RG L +L +L Sbjct: 238 LKRIME--VVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRML 295 Query: 286 EADQEK 291 D ++ Sbjct: 296 VLDSDQ 301 >3M42-A nrPDB Length = 299 Score = 62.4 bits (150), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 52/213 (24%), Positives = 91/213 (42%), Gaps = 40/213 (18%) Query: 12 SDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNH-KNIVKL 70 S +LG G V + +K+T + FA+K+ + R RE E+ + + +IV++ Sbjct: 23 SQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKAR------REVELHWRASQCPHIVRI 76 Query: 71 FAIEEETTTRHKVL--IMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE 128 + E K L +ME G L++ +++ + E E +++ + + +L Sbjct: 77 VDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQ-AFTEREASEIMKSIGEAIQYLHS 135 Query: 129 NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERA 188 I HRD+KP N++ + ++ KLTDFG A+E + Sbjct: 136 INIAHRDVKPENLL-YTSKRPNAILKLTDFGFAKETTGE--------------------- 173 Query: 189 VLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 KY + D+WS+GV Y G PF Sbjct: 174 --------KYDKSCDMWSLGVIMYILLCGYPPF 198 >4UYA-A nrPDB Length = 340 Score = 62.4 bits (150), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 57/226 (25%), Positives = 95/226 (42%), Gaps = 27/226 (11%) Query: 11 LSDILGQGATANVFRGRHKKTGDLFAIKVFNN---ISFLRPVDVQMREFEVLKKLNHKNI 67 L +++G G V+R + G A+K + RE + L H NI Sbjct: 30 LKELIGAGGFGQVYRATWQ--GQEVAVKAARQDPEQDAAAAAESVRREARLFAMLRHPNI 87 Query: 68 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 127 ++L + + H L++EF G+L L +P + + GM +L Sbjct: 88 IELRGVCLQQP--HLCLVLEFARGGALNRAL----AGRRIPPHVLVNWAVQIARGMLYLH 141 Query: 128 ENG---IVHRDIKPGNIMRV--IGEDG--QSVYKLTDFGAARELEDDEQFVSLYGTEEYL 180 E I+HRD+K NI+ + I D K+TDFG ARE + + G ++ Sbjct: 142 EEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKMAT-AGAYAWM 200 Query: 181 HPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEG 226 P++ + ++ K D+WS GV + TG +P+R +G Sbjct: 201 APEVIKSSLFSKGS--------DIWSYGVLLWELLTGEVPYRGIDG 238 >2R2P-A nrPDB Length = 295 Score = 62.4 bits (150), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 57/217 (26%), Positives = 101/217 (46%), Gaps = 26/217 (11%) Query: 14 ILGQGATANVFRGRHKKTGDL---FAIKVFNNISFLRPVDVQMREF----EVLKKLNHKN 66 ++G G V GR K G AIK + + + Q R+F ++ + +H N Sbjct: 29 VIGAGEFGEVCSGRLKLPGKRELPVAIKTLK-VGY---TEKQRRDFLGEASIMGQFDHPN 84 Query: 67 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 126 I+ L + T ++ +++ E+ GSL T L++ + + + + +LR + GM +L Sbjct: 85 IIHLEGVV--TKSKPVMIVTEYMENGSLDTFLKKNDGQFTV--IQLVGMLRGISAGMKYL 140 Query: 127 RENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD-EQFVSLYGTEEYLHPDMY 185 + G VHRD+ NI+ + V K++DFG +R LEDD E + G + + Sbjct: 141 SDMGYVHRDLAARNILI----NSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAP 196 Query: 186 ERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPF 221 E R K+ + D+WS G+ + + G P+ Sbjct: 197 EAIAFR-----KFTSASDVWSYGIVMWEVVSYGERPY 228 >1V0B-A nrPDB Length = 288 Score = 62.0 bits (149), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 62/221 (28%), Positives = 100/221 (45%), Gaps = 40/221 (18%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVD-----VQMREFEVLKKLNHKNIVK 69 +G+G V++ ++ G+ FA+K L D +RE +LK+L H NIVK Sbjct: 10 IGEGTYGVVYKAQNN-YGETFALKKIR----LEKEDEGIPSTTIREISILKELKHSNIVK 64 Query: 70 LFAIEEETTTRHKVLIMEFCP--CGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 127 L+ + T + VL+ E L V E GL L ++ G+ + Sbjct: 65 LYDVIH--TKKRLVLVFEHLDQDLKKLLDVCEG-----GLESVTAKSFLLQLLNGIAYCH 117 Query: 128 ENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAAREL-----EDDEQFVSLYGTEEYLHP 182 + ++HRD+KP N++ I +G+ K+ DFG AR + + V+L+ Y P Sbjct: 118 DRRVLHRDLKPQNLL--INREGE--LKIADFGLARAFGIPVRKYTHEVVTLW----YRAP 169 Query: 183 DMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRP 223 D+ + KKY T+D+WS+G F G+ P P Sbjct: 170 DVLMGS-------KKYSTTIDIWSVGCIFAEMVNGA-PLFP 202 >2F9G-A nrPDB Length = 353 Score = 62.0 bits (149), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 55/207 (26%), Positives = 94/207 (45%), Gaps = 20/207 (9%) Query: 11 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDV--QMREFEVLKKLNHKNIV 68 L +LG+GA V HK TG++ AIK F +P+ +RE ++LK H+NI+ Sbjct: 15 LKSLLGEGAYGVVCSATHKPTGEIVAIKKIE--PFDKPLFALRTLREIKILKHFKHENII 72 Query: 69 KLFAIEEETTTR--HKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 126 +F I+ + ++V I++ L+ V+ + L + + + + L Sbjct: 73 TIFNIQRPDSFENFNEVYIIQELMQTDLHRVI----STQMLSDDHIQYFIYQTLRAVKVL 128 Query: 127 RENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAAREL-----EDDEQFVSLYGTEEYLH 181 + ++HRD+KP N++ + K+ DFG AR + ++ E G EY+ Sbjct: 129 HGSNVIHRDLKPSNLLI----NSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVA 184 Query: 182 PDMYERAVLRKDHQKKYGATVDLWSIG 208 Y RA KY +D+WS G Sbjct: 185 TRWY-RAPEVMLTSAKYSRAMDVWSCG 210 >4CSV-A nrPDB Length = 275 Score = 62.0 bits (149), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 57/237 (24%), Positives = 105/237 (44%), Gaps = 26/237 (10%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 74 LG G V+ G+ + A+K + V+ ++E +++KKL H N+V+L+ + Sbjct: 19 LGSGQFGEVYEGKWRNYNIEVAVKTLKEGTM--SVEEFLQEAQIMKKLKHPNLVQLYGV- 75 Query: 75 EETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHR 134 T +I E+ GSL L + + + L + V GM +L +HR Sbjct: 76 -CTKEPPIYIITEYMSHGSLLDYLRD-CEGHTVNAQALLDMAAQVASGMAYLESQNFIHR 133 Query: 135 DIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTE---EYLHPDM--YERAV 189 D+ N + +GE+ +V K+ DFG AR + +DE + + G + ++ P+ Y R Sbjct: 134 DLAARNCL--VGEN--NVVKVADFGLARLINEDE-YTARAGAKFPIKWTAPEAISYNRFS 188 Query: 190 LRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVMYKIITGKPSGA 245 ++ D+W+ G+ + T G +P+ G ++V +P G Sbjct: 189 IKS----------DVWAFGILLWEIFTYGQVPYPGMSGSEVIEQVERGYRMPRPQGC 235 >6GVJ-A nrPDB Length = 429 Score = 62.0 bits (149), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 56/219 (25%), Positives = 108/219 (49%), Gaps = 25/219 (11%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFN-NISFLRPVDVQMREFEVLKKLNHKN--IVKLF 71 +G G ++ VF+ ++K ++AIK N + + +D E L KL + I++L+ Sbjct: 152 IGSGGSSKVFQVLNEKK-QIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRLY 210 Query: 72 AIEEETTTRHKVLIMEFCPCGS--LYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN 129 + E T ++ ++ME CG+ L + L++ + + ++++ ++ + ++ Sbjct: 211 --DYEITDQYIYMVME---CGNIDLNSWLKKKKSIDPWERKSYW---KNMLEAVHTIHQH 262 Query: 130 GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFV---SLYGTEEYLHPDMYE 186 GIVH D+KP N + V G + KL DFG A +++ D V S GT Y+ P+ + Sbjct: 263 GIVHSDLKPANFLIVDG-----MLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIK 317 Query: 187 RAVLRKDH---QKKYGATVDLWSIGVTFYHAATGSLPFR 222 +++ + K D+WS+G Y+ G PF+ Sbjct: 318 DMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ 356 >3DKO-A nrPDB Length = 318 Score = 61.6 bits (148), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 57/218 (26%), Positives = 100/218 (45%), Gaps = 28/218 (12%) Query: 14 ILGQGATANVFRGRHKKTGD---LFAIKVFNNISFLRPVDVQMREF----EVLKKLNHKN 66 ++G G V GR K G AIK + + Q R+F ++ + +H N Sbjct: 50 VIGAGEFGEVCSGRLKLPGKRDVAVAIKTLK----VGYTEKQRRDFLCEASIMGQFDHPN 105 Query: 67 IVKLFAIEEETTTRHK--VLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 124 +V L E TR K ++++EF G+L L + + + + + +LR + GM Sbjct: 106 VVHL----EGVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTV--IQLVGMLRGIAAGMR 159 Query: 125 HLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDM 184 +L + G VHRD+ NI+ + V K++DFG +R +EDD + ++Y T P Sbjct: 160 YLADMGYVHRDLAARNIL----VNSNLVCKVSDFGLSRVIEDDPE--AVYTTTGGKIPVR 213 Query: 185 YERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPF 221 + +K+ + D+WS G+ + + G P+ Sbjct: 214 W--TAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPY 249 >4IAN-A nrPDB Length = 358 Score = 61.6 bits (148), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 58/214 (27%), Positives = 94/214 (43%), Gaps = 26/214 (12%) Query: 16 GQGATANVFRGR-HKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKN------IV 68 GQG +NV R R + + A+K+ N ++ ++E E LKKLN + + Sbjct: 39 GQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTG--LKELEFLKKLNDADPDDKFHCL 96 Query: 69 KLFAIEEETTTRHKVLIMEFCPCG-SLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 127 +LF +H L+ E P +L VL++ GL + + + L+ Sbjct: 97 RLF--RHFYHKQHLCLVFE--PLSMNLREVLKKYGKDVGLHIKAVRSYSQQLFLALKLLK 152 Query: 128 ENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYER 187 I+H DIKP NI+ + +++ KL DFG+A + D++ YL Y Sbjct: 153 RCNILHADIKPDNIL---VNESKTILKLCDFGSASHVADND-------ITPYLVSRFYRA 202 Query: 188 AVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 + YG +D+WS+G T Y TG + F Sbjct: 203 PEIIIGKSYDYG--IDMWSVGCTLYELYTGKILF 234 >3E7O-A nrPDB Length = 360 Score = 61.2 bits (147), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 51/176 (28%), Positives = 77/176 (43%), Gaps = 28/176 (15%) Query: 54 REFEVLKKLNHKNIVKLFAIEEETTTRHKV----LIMEFCP---CGSLYTVLEEPSNAYG 106 RE +LK +NHKNI+ L + T + L+ME C ++ L+ +Y Sbjct: 70 RELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSY- 128 Query: 107 LPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELED 166 +L ++ G+ HL GI+HRD+KP NI V+ D K+ DFG AR Sbjct: 129 --------LLYQMLCGIKHLHSAGIIHRDLKPSNI--VVKSD--CTLKILDFGLARTAST 176 Query: 167 DEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFR 222 + T Y P++ +L Y VD+WS+G GS+ F+ Sbjct: 177 NFMMTPYVVTRYYRAPEV----IL----GMGYKENVDIWSVGCIMGELVKGSVIFQ 224 >4H1J-A nrPDB Length = 293 Score = 61.2 bits (147), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 67/238 (28%), Positives = 98/238 (41%), Gaps = 41/238 (17%) Query: 10 LLSDILGQGATANVFRG---RHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKN 66 +L+ ILG+G V+ G HK A+K L + M E ++K L+H + Sbjct: 27 VLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPH 86 Query: 67 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 126 IVKL I EE T +IME P G L LE N+ L ++ + M +L Sbjct: 87 IVKLIGIIEEEPTW---IIMELYPYGELGHYLERNKNS--LKVLTLVLYSLQICKAMAYL 141 Query: 127 RENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYE 186 VHRDI NI+ E KL DFG +R +ED+ D Y+ Sbjct: 142 ESINCVHRDIAVRNILVASPE----CVKLGDFGLSRYIEDE---------------DYYK 182 Query: 187 RAVLRKDHQ---------KKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVM 234 +V R + +++ D+W V + + G PF E NK+V+ Sbjct: 183 ASVTRLPIKWMSPESINFRRFTTASDVWMFAVCMWEILSFGKQPFFWLE----NKDVI 236 >5O2C-A nrPDB Length = 380 Score = 61.2 bits (147), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 60/214 (28%), Positives = 97/214 (45%), Gaps = 25/214 (11%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMRE-FEVLKKLNHKNIVKLFAI 73 LG+GA V++G +T A + + + +E E+LK L H NIV+ + Sbjct: 33 LGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDS 92 Query: 74 EEETTTRHK--VLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIV-LRDVVGGMN--HLRE 128 E K VL+ E G+L T L+ + + + + L R ++ G+ H R Sbjct: 93 WESILKGKKCIVLVTELMTSGTLKTYLKR----FKVMKPKVLRSWCRQILKGLQFLHTRT 148 Query: 129 NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFV-SLYGTEEYLHPDMYER 187 I+HRD+K NI + G G K+ D G A + F S+ GT E++ P+MYE Sbjct: 149 PPIIHRDLKCDNIF-ITGPTGS--VKIGDLGLATLMRT--SFAKSVIGTPEFMAPEMYE- 202 Query: 188 AVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 + Y +VD+++ G+ AT P+ Sbjct: 203 --------EHYDESVDVYAFGMCMLEMATSEYPY 228 >3EB0-A nrPDB Length = 383 Score = 61.2 bits (147), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 62/245 (25%), Positives = 104/245 (42%), Gaps = 53/245 (21%) Query: 4 TSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLN 63 TS+ + L LG G+ V ++G FA+K L+ + RE +++K L+ Sbjct: 4 TSSKKYSLGKTLGTGSFGIVCEVFDIESGKRFALK-----KVLQDPRYKNRELDIMKVLD 58 Query: 64 HKNIVKLF------------------------------------AIEEETTTRHKVLIME 87 H NI+KL I + ++ +IME Sbjct: 59 HVNIIKLVDYFYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNVIME 118 Query: 88 FCPCGSLYTVLEE-PSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIG 146 + P +L+ VL+ + +P + I + + + + GI HRDIKP N++ V Sbjct: 119 YVP-DTLHKVLKSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLL-VNS 176 Query: 147 EDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWS 206 +D + KL DFG+A++L E V+ + Y P++ A +Y ++DLWS Sbjct: 177 KD--NTLKLCDFGSAKKLIPSEPSVAYICSRFYRAPELMLGAT-------EYTPSIDLWS 227 Query: 207 IGVTF 211 IG F Sbjct: 228 IGCVF 232 >5EFQ-A nrPDB Length = 347 Score = 60.8 bits (146), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 56/209 (26%), Positives = 100/209 (47%), Gaps = 29/209 (13%) Query: 14 ILGQGATANVFRGRHKKTGDLFAIKV--FNNISFLRPVDVQMREFEVLKKLNHKNIVKLF 71 I+G+G V++ R K TG++ A+K +N P+ +RE ++L++L H++I+ + Sbjct: 18 IIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPI-TAIREIKILRQLTHQSIINM- 75 Query: 72 AIEEETTTRHKVLIMEFCPCGSLYTVLE-EPSNAYGLPESEFL--------IVLRDVVGG 122 +E T + L + G+ Y V E + GL ES + +R ++ G Sbjct: 76 --KEIVTDKEDALDFKKDK-GAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEG 132 Query: 123 MNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAAR--ELEDDEQFVSLYGTEEYL 180 +++ + +HRDIK NI+ + GQ KL DFG AR E+ + + T Y Sbjct: 133 LDYCHKKNFLHRDIKCSNIL--LNNRGQ--IKLADFGLARLYSSEESRPYTNKVITLWYR 188 Query: 181 HPDMYERAVLRKDHQKKYGATVDLWSIGV 209 P++ +++Y +D+WS G Sbjct: 189 PPELLL-------GEERYTPAIDVWSCGC 210 >5O2B-A nrPDB Length = 285 Score = 60.8 bits (146), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 61/214 (28%), Positives = 98/214 (45%), Gaps = 25/214 (11%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMRE-FEVLKKLNHKNIVKLFAI 73 LG+GA V++G +T A + + + +E E+LK L H NIV+ + Sbjct: 24 LGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDS 83 Query: 74 EEETTTRHK--VLIMEFCPCGSLYTVLEEPSNAYGLPESEFL-IVLRDVVGGMN--HLRE 128 E K VL+ E G+L T L+ + + + + L R ++ G+ H R Sbjct: 84 WESILKGKKCIVLVTELMTSGTLKTYLKR----FKVMKPKVLRSWCRQILKGLQFLHTRT 139 Query: 129 NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFV-SLYGTEEYLHPDMYER 187 I+HRD+K NI + G G K+ D G A + F S+ GT E++ P+MYE Sbjct: 140 PPIIHRDLKCDNIF-ITGPTGS--VKIGDLGLATLMRTS--FAKSVIGTPEFMAPEMYE- 193 Query: 188 AVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 +H Y +VD+++ G+ AT P+ Sbjct: 194 -----EH---YDESVDVYAFGMCMLEMATSEYPY 219 >3HMP-A nrPDB Length = 342 Score = 60.8 bits (146), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 56/219 (25%), Positives = 108/219 (49%), Gaps = 25/219 (11%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFN-NISFLRPVDVQMREFEVLKKLNHKN--IVKLF 71 +G G ++ VF+ ++K ++AIK N + + +D E L KL + I++L+ Sbjct: 64 IGSGGSSKVFQVLNEKK-QIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRLY 122 Query: 72 AIEEETTTRHKVLIMEFCPCGS--LYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN 129 + E T ++ ++ME CG+ L + L++ + + ++++ ++ + ++ Sbjct: 123 --DYEITDQYIYMVME---CGNIDLNSWLKKKKSIDPWERKSYW---KNMLEAVHTIHQH 174 Query: 130 GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFV---SLYGTEEYLHPDMYE 186 GIVH D+KP N + V G + KL DFG A +++ D V S GT Y+ P+ + Sbjct: 175 GIVHSDLKPANFLIVDG-----MLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIK 229 Query: 187 RAVLRKDH---QKKYGATVDLWSIGVTFYHAATGSLPFR 222 +++ + K D+WS+G Y+ G PF+ Sbjct: 230 DMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ 268 >4X7Q-B nrPDB Length = 312 Score = 60.5 bits (145), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 66/235 (28%), Positives = 99/235 (42%), Gaps = 34/235 (14%) Query: 11 LSDILGQGATANVFRGRHKKTGDL-FAIKVF--NNISFLRPVDVQMR---EFEVLKKLN- 63 L +LG+G VF G H+ T L AIKV N + P+ + E +L K+ Sbjct: 35 LGPLLGKGGFGTVFAG-HRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGA 93 Query: 64 ---HKNIVKLFAIEEETTTRHKVLIME-FCPCGSLYTVLEEPSNAYGLPESEFLIVLRDV 119 H +++L E T +L++E P L+ + E L E V Sbjct: 94 GGGHPGVIRLLDWFE--TQEGFMLVLERPLPAQDLFDYITEKGP---LGEGPSRCFFGQV 148 Query: 120 VGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEY 179 V + H G+VHRDIK NI+ + + KL DFG+ L DE + GT Y Sbjct: 149 VAAIQHCHSRGVVHRDIKDENILIDL---RRGCAKLIDFGSGALLH-DEPYTDFDGTRVY 204 Query: 180 LHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVM 234 P+ R HQ + +WS+G+ Y G +PF R++E++ Sbjct: 205 SPPEWISR------HQ-YHALPATVWSLGILLYDMVCGDIPF------ERDQEIL 246 >3OHT-A nrPDB Length = 389 Score = 60.5 bits (145), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 57/241 (23%), Positives = 105/241 (43%), Gaps = 33/241 (13%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQM------REFEVLKKLNHKNIV 68 +G GA +V K+G A+K + RP + RE +LK + H+N++ Sbjct: 59 VGSGAYGSVCSSYDVKSGLKIAVKKLS-----RPFQSIIHAKRTYRELRLLKHMKHENVI 113 Query: 69 KLFAIEEETTTR---HKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 125 L + T+ + V ++ L +++ L + ++ ++ G+ + Sbjct: 114 GLLDVFTPATSLEEFNDVYLVTHLMGADLNNIVK----CQKLTDDHVQFLIYQILRGLKY 169 Query: 126 LRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMY 185 + I+HRD+KP N+ + ED + K+ DFG AR D++ T Y P++ Sbjct: 170 IHSADIIHRDLKPSNL--AVNEDCE--LKILDFGLARHT--DDEMTGYVATRWYRAPEI- 222 Query: 186 ERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGA 245 +L H Y TVD+WS+G TG F + + +++M +TG P + Sbjct: 223 ---MLNWMH---YNMTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMR--LTGTPPAS 274 Query: 246 I 246 + Sbjct: 275 V 275 >6CTH-A nrPDB Length = 309 Score = 60.5 bits (145), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 60/214 (28%), Positives = 96/214 (44%), Gaps = 22/214 (10%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 74 LG+G +V+RG + + A+K + S + + E +++ +L HKN+VKL Sbjct: 23 LGEGGFGSVYRGFLRDSDTYIAVKKVSRAS-KQGIKEYASEVKIISRLRHKNLVKLIGWC 81 Query: 75 EETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG---I 131 E +L+ EF GSL + + + + E + IV +D+ + +L E G + Sbjct: 82 HERG--ELMLVYEFMANGSLDSHIFKGKSLLTW-EVRYRIV-KDLASALLYLHEEGDHCV 137 Query: 132 VHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQF--VSLYGTEEYLHPDMYERAV 189 +HRDIK NIM D KL DFG AR ++ + L GT Y+ P+ Sbjct: 138 LHRDIKTSNIML----DSSFNAKLGDFGLARLVDHAKGLKKTLLAGTVGYMAPECLSSGK 193 Query: 190 LRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRP 223 K+ D++S GV A+G P Sbjct: 194 ASKES--------DVYSFGVVALEIASGRRSIEP 219 >4Y93-A nrPDB Length = 446 Score = 60.1 bits (144), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 57/216 (26%), Positives = 99/216 (45%), Gaps = 28/216 (12%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 74 LG G V G+ + D+ AIK+ S D + E +V+ L+H+ +V+L+ + Sbjct: 196 LGTGQFGVVKYGKWRGQYDV-AIKMIKEGSMSE--DEFIEEAKVMMNLSHEKLVQLYGVC 252 Query: 75 EETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHR 134 T R +I E+ G L L E + + + L + +DV M +L +HR Sbjct: 253 --TKQRPIFIITEYMANGCLLNYLREMRHRFQT--QQLLEMCKDVCEAMEYLESKQFLHR 308 Query: 135 DIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTE---EYLHPD--MYERAV 189 D+ N + + Q V K++DFG R + DDE + S G++ ++ P+ MY Sbjct: 309 DLAARNCLV----NDQGVVKVSDFGMTRYVLDDE-YTSSTGSKFPVKWASPEVLMY---- 359 Query: 190 LRKDHQKKYGATVDLWSIGVTFYHA-ATGSLPFRPF 224 K+ + D+W+ GV + + G +P+ F Sbjct: 360 ------SKFSSKSDIWAFGVLMWEIYSLGKMPYERF 389 >5AMN-A nrPDB Length = 299 Score = 60.1 bits (144), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 62/228 (27%), Positives = 103/228 (45%), Gaps = 30/228 (13%) Query: 10 LLSDILGQG-------ATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKL 62 +L LG+G ATA +GR T A+K+ + + + EF VLK++ Sbjct: 26 VLGKTLGEGEFGKVVKATAFHLKGRAGYT--TVAVKMLKENASPSELRDLLSEFNVLKQV 83 Query: 63 NHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSN-AYGLPESEFLIVLRDVVG 121 NH +++KL+ + +LI+E+ GSL L E G P+ E + + D++ Sbjct: 84 NHPHVIKLYGACSQDGPL--LLIVEYAKYGSLRGFLRESRKVGPGYPD-ERALTMGDLIS 140 Query: 122 -------GMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLY 174 GM +L E +VHRD+ NI+ G K++DFG +R++ +++ +V Sbjct: 141 FAWQISQGMQYLAEMKLVHRDLAARNILVAEGRK----MKISDFGLSRDVYEEDSYVK-- 194 Query: 175 GTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPF 221 + P + DH Y D+WS GV + T G P+ Sbjct: 195 -RSQGRIPVKWMAIESLFDHI--YTTQSDVWSFGVLLWEIVTLGGNPY 239 >4EBW-A nrPDB Length = 304 Score = 60.1 bits (144), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 62/291 (21%), Positives = 115/291 (39%), Gaps = 57/291 (19%) Query: 11 LSDILGQGATANVFRGRHKKTGD---LFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNI 67 L +G+G +V +G + + AIK N + + ++E +++ +H +I Sbjct: 42 LGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHI 101 Query: 68 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 127 VKL + E +IME C G L + L+ Y L + ++ + + +L Sbjct: 102 VKLIGVITENPV---WIIMELCTLGELRSFLQ--VRKYSLDLASLILYAYQLSTALAYLE 156 Query: 128 ENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYG--TEEYLHPDMY 185 VHRDI N++ KL DFG +R +ED + + G +++ P+ Sbjct: 157 SKRFVHRDIAARNVL----VSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPE-- 210 Query: 186 ERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGA 245 + +++ + D+W GV + + +PF+G + N Sbjct: 211 ------SINFRRFTSASDVWMFGVCMWEILMHGV--KPFQGVKNND-------------V 249 Query: 246 ISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFD 296 I ++ E P MP +C P L +++ KCW +D Sbjct: 250 IGRIENGERLP------MPPNCP----------PTLYSLM----TKCWAYD 280 >4P5Q-A nrPDB Length = 361 Score = 60.1 bits (144), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 55/219 (25%), Positives = 101/219 (46%), Gaps = 24/219 (10%) Query: 11 LSDILGQGATANVFRGRHK---KTGDLFAIKVFNNISFLRPVDVQMREF----EVLKKLN 63 + ++G G V GR K K AIK + + Q R+F ++ + + Sbjct: 37 IDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLK----VGYTEKQRRDFLGEASIMGQFD 92 Query: 64 HKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 123 H NI++L + T ++ +++ E+ GSL + L + + + + + +LR + GM Sbjct: 93 HPNIIRLEGVV--TKSKPVMIVTEYMENGSLDSFLRKHDAQFTV--IQLVGMLRGIASGM 148 Query: 124 NHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPD 183 +L + G VHRD+ NI+ + V K++DFG +R LEDD + + Y T P Sbjct: 149 KYLSDMGYVHRDLAARNILI----NSNLVCKVSDFGLSRVLEDDPE--AAYTTRGGKIPI 202 Query: 184 MYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPF 221 + +K+ + D+WS G+ + + G P+ Sbjct: 203 RWTSP--EAIAYRKFTSASDVWSYGIVLWEVMSYGERPY 239 >2VWV-A nrPDB Length = 302 Score = 60.1 bits (144), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 63/228 (27%), Positives = 97/228 (42%), Gaps = 40/228 (17%) Query: 11 LSDILGQGATANVFRGRHKKTG---DLFAIKVFNNISFLRPVDVQMREF----EVLKKLN 63 + +++G G V RGR K G AIK R Q REF ++ + Sbjct: 20 IEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTER----QRREFLSEASIMGQFE 75 Query: 64 HKNIVKLFAIEEETTTRHKVLIM-EFCPCGSLYTVLEEPSNAYGLPESEFLIV-----LR 117 H NI++L E T V+I+ EF G+L + L L + +F ++ LR Sbjct: 76 HPNIIRL---EGVVTNSMPVMILTEFMENGALDSFLR-------LNDGQFTVIQLVGMLR 125 Query: 118 DVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELED---DEQFVSLY 174 + GM +L E VHRD+ NI+ + V K++DFG +R LE+ D S Sbjct: 126 GIASGMRYLAEMSYVHRDLAARNIL----VNSNLVCKVSDFGLSRFLEENSSDPTETSSL 181 Query: 175 GTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPF 221 G + + E R K+ + D WS G+ + + G P+ Sbjct: 182 GGKIPIRWTAPEAIAFR-----KFTSASDAWSYGIVMWEVMSFGERPY 224 >2PL0-A nrPDB Length = 289 Score = 60.1 bits (144), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 61/234 (26%), Positives = 106/234 (45%), Gaps = 26/234 (11%) Query: 11 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKL 70 L + LG G V+ G + + A+K S + P D + E ++K+L H+ +V+L Sbjct: 27 LVERLGAGQFGEVWMGYYNGHTKV-AVKSLKQGS-MSP-DAFLAEANLMKQLQHQRLVRL 83 Query: 71 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 130 +A+ T +I E+ GSL L+ PS L ++ L + + GM + E Sbjct: 84 YAV---VTQEPIYIITEYMENGSLVDFLKTPS-GIKLTINKLLDMAAQIAEGMAFIEERN 139 Query: 131 IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTE---EYLHPDMYER 187 +HRD++ NI+ D S K+ DFG AR +ED+E + + G + ++ P+ Sbjct: 140 YIHRDLRAANILV---SDTLSC-KIADFGLARLIEDNE-YTAREGAKFPIKWTAPEAINY 194 Query: 188 AVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPR--RNKEVMYKII 238 + D+WS G+ T G +P+ P +N E Y+++ Sbjct: 195 GT--------FTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMV 240 >5AP3-A nrPDB Length = 313 Score = 59.7 bits (143), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 56/219 (25%), Positives = 107/219 (48%), Gaps = 25/219 (11%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFN-NISFLRPVDVQMREFEVLKKLNHKN--IVKLF 71 +G G ++ VF+ ++K ++AIK N + + +D E L KL + I++L+ Sbjct: 36 IGSGGSSKVFQVLNEKK-QIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRLY 94 Query: 72 AIEEETTTRHKVLIMEFCPCGS--LYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN 129 + E T ++ ++ME CG+ L L++ + + ++++ ++ + ++ Sbjct: 95 --DYEITDQYIYMVME---CGNIDLNGWLKKKKSIDPWERKSYW---KNMLEAVHTIHQH 146 Query: 130 GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFV---SLYGTEEYLHPDMYE 186 GIVH D+KP N + V G + KL DFG A +++ D V S GT Y+ P+ + Sbjct: 147 GIVHSDLKPANFLIVDG-----MLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIK 201 Query: 187 RAVLRKDH---QKKYGATVDLWSIGVTFYHAATGSLPFR 222 +++ + K D+WS+G Y+ G PF+ Sbjct: 202 DMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ 240 >6E4F-A nrPDB Length = 290 Score = 59.3 bits (142), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 57/216 (26%), Positives = 99/216 (45%), Gaps = 28/216 (12%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 74 LG G V G+ + D+ AIK+ S D + E +V+ L+H+ +V+L+ + Sbjct: 39 LGTGQFGVVKYGKWRGQYDV-AIKMIKEGSMSE--DEFIEEAKVMMNLSHEKLVQLYGVC 95 Query: 75 EETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHR 134 T R +I E+ G L L E + + + L + +DV M +L +HR Sbjct: 96 --TKQRPIFIITEYMANGCLLNYLREMRHRF--QTQQLLEMCKDVCEAMEYLESKQFLHR 151 Query: 135 DIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTE---EYLHPD--MYERAV 189 D+ N + + Q V K++DFG +R + DDE + S G++ + P+ MY Sbjct: 152 DLAARNCLV----NDQGVVKVSDFGLSRYVLDDE-YTSSVGSKFPVRWSPPEVLMY---- 202 Query: 190 LRKDHQKKYGATVDLWSIGVTFYHA-ATGSLPFRPF 224 K+ + D+W+ GV + + G +P+ F Sbjct: 203 ------SKFSSKSDIWAFGVLMWEIYSLGKMPYERF 232 >4XI2-A nrPDB Length = 446 Score = 59.3 bits (142), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 57/216 (26%), Positives = 99/216 (45%), Gaps = 28/216 (12%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 74 LG G V G+ + D+ AIK+ S D + E +V+ L+H+ +V+L+ + Sbjct: 195 LGTGQFGVVKYGKWRGQYDV-AIKMIREGSMSE--DEFIEEAKVMMNLSHEKLVQLYGVC 251 Query: 75 EETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHR 134 T R +I E+ G L L E + + + L + +DV M +L +HR Sbjct: 252 --TKQRPIFIITEYMANGCLLNYLREMRHRF--QTQQLLEMCKDVCEAMEYLESKQFLHR 307 Query: 135 DIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTE---EYLHPD--MYERAV 189 D+ N + + Q V K++DFG +R + DDE + S G++ + P+ MY Sbjct: 308 DLAARNCLV----NDQGVVKVSDFGLSRYVLDDE-YTSSVGSKFPVRWSPPEVLMY---- 358 Query: 190 LRKDHQKKYGATVDLWSIGVTFYHA-ATGSLPFRPF 224 K+ + D+W+ GV + + G +P+ F Sbjct: 359 ------SKFSSKSDIWAFGVLMWEIYSLGKMPYERF 388 >4ZSG-A nrPDB Length = 347 Score = 59.3 bits (142), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 68/259 (26%), Positives = 115/259 (44%), Gaps = 41/259 (15%) Query: 13 DILGQGATANVFRGRHKKTGDLFAIK-VFNNISFLRPVDVQMREFEVLKKLNHKNIVKLF 71 + +G GA V R + TG AIK + N + +RE ++LK H NI+ + Sbjct: 13 ETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAI- 71 Query: 72 AIEEETTTRHKVLIMEFCPCGSLYTVLE-EPSNAYGLPESEFLIVLRDV-------VGGM 123 + R V EF S+Y VL+ S+ + + S + L V + G+ Sbjct: 72 ----KDILRPTVPYGEF---KSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGL 124 Query: 124 NHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAAREL----EDDEQFVSLY-GTEE 178 ++ ++HRD+KP N++ + E+ + K+ DFG AR L + + F++ Y T Sbjct: 125 KYMHSAQVIHRDLKPSNLL--VNENCE--LKIGDFGMARGLCTSPAEHQYFMTEYVATRW 180 Query: 179 YLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRN---KEVMY 235 Y P++ + H+ Y +DLWS+G F G + R P +N + + Sbjct: 181 YRAPEL-----MLSLHE--YTQAIDLWSVGCIF-----GEMLARRQLFPGKNYVHQLQLI 228 Query: 236 KIITGKPSGAISGVQKAEN 254 ++ G PS A+ AE Sbjct: 229 MMVLGTPSPAVIQAVGAER 247 >1JPA-A nrPDB Length = 312 Score = 58.9 bits (141), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 54/224 (24%), Positives = 102/224 (45%), Gaps = 32/224 (14%) Query: 11 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRP--VDVQMREF----EVLKKLNH 64 + ++G G V G K G ++F I L+ + Q R+F ++ + +H Sbjct: 37 IEQVIGAGEFGEVCSGHLKLPGKR---EIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDH 93 Query: 65 KNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 124 N++ L + ++T ++I EF GSL + L + + + + + +LR + GM Sbjct: 94 PNVIHLEGVVTKSTP--VMIITEFMENGSLDSFLRQNDGQFTV--IQLVGMLRGIAAGMK 149 Query: 125 HLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQ---FVSLYGTE---E 178 +L + VHRD+ NI+ + V K++DFG +R LEDD + S G + Sbjct: 150 YLADMNYVHRDLAARNIL----VNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIR 205 Query: 179 YLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPF 221 + P+ + +K+ + D+WS G+ + + G P+ Sbjct: 206 WTAPEAIQ--------YRKFTSASDVWSYGIVMWEVMSYGERPY 241 >4IC8-A nrPDB Length = 442 Score = 58.9 bits (141), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 59/213 (27%), Positives = 98/213 (46%), Gaps = 33/213 (15%) Query: 13 DILGQGATANVFRGRHKKTGDLFAIK-VFNNISFLRPVDVQMREFEVLKKLNHKNIVKLF 71 + +G GA V R + TG AIK + N + +RE ++LK H NI+ + Sbjct: 61 ETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIK 120 Query: 72 AIEEETTTRHKVLIMEFCPCGSLYTVLE-EPSNAYGLPESEFLIVLRDV-------VGGM 123 I R V EF S+Y VL+ S+ + + S + L V + G+ Sbjct: 121 DI-----LRPTVPYGEF---KSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGL 172 Query: 124 NHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAAREL----EDDEQFVSLY-GTEE 178 ++ ++HRD+KP N++ + E+ + K+ DFG AR L + + F++ Y T Sbjct: 173 KYMHSAQVIHRDLKPSNLL--VNENCE--LKIGDFGMARGLCTSPAEHQYFMTEYVATRW 228 Query: 179 YLHPDMYERAVLRKDHQKKYGATVDLWSIGVTF 211 Y P++ + H+ Y +DLWS+G F Sbjct: 229 YRAPEL-----MLSLHE--YTQAIDLWSVGCIF 254 >3NYO-A nrPDB Length = 576 Score = 58.9 bits (141), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 51/212 (24%), Positives = 92/212 (43%), Gaps = 19/212 (8%) Query: 14 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQM--REFEVLKKLNHKNIVKL- 70 +LG+G V + + TG ++A K + M E ++L+K+N + +V L Sbjct: 191 VLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLA 250 Query: 71 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 130 +A E T L++ G L + A G PE+ + ++ G+ L Sbjct: 251 YAYE---TKDALCLVLTLMNGGDLKFHIYHMGQA-GFPEARAVFYAAEICCGLEDLHRER 306 Query: 131 IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVL 190 IV+RD+KP NI+ D +++D G A + + + GT Y+ P++ + Sbjct: 307 IVYRDLKPENILL----DDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVK---- 358 Query: 191 RKDHQKKYGATVDLWSIGVTFYHAATGSLPFR 222 ++Y + D W++G Y G PF+ Sbjct: 359 ----NERYTFSPDWWALGCLLYEMIAGQSPFQ 386 >3N9X-A nrPDB Length = 432 Score = 58.9 bits (141), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 54/229 (23%), Positives = 101/229 (44%), Gaps = 40/229 (17%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHKN 66 +++ ++G+G+ V+ K T AIK N + F +D + +RE +L +L Sbjct: 28 YIIKHLIGRGSYGYVYLAYDKNTEKNVAIKKVNRM-FEDLIDCKRILREITILNRLKSDY 86 Query: 67 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYG--------LPESEFLIVLRD 118 I++L+ + ++ + LY VLE + L E +L + Sbjct: 87 IIRLYDL---------IIPDDLLKFDELYIVLEIADSDLKKLFKTPIFLTEEHIKTILYN 137 Query: 119 VVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEE 178 ++ G N + E+GI+HRD+KP N + + +D K+ DFG AR + ++ + EE Sbjct: 138 LLLGENFIHESGIIHRDLKPANCL--LNQDCS--VKVCDFGLARTINSEKDTNIVNDLEE 193 Query: 179 YLHPDMYERAVLRK--DH--------------QKKYGATVDLWSIGVTF 211 P + + + ++ H Q+ Y ++D+WS G F Sbjct: 194 NEEPGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTKSIDIWSTGCIF 242 >4PDO-A nrPDB Length = 299 Score = 58.9 bits (141), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 61/235 (25%), Positives = 105/235 (44%), Gaps = 27/235 (11%) Query: 14 ILGQGATANVFRGRHKKTGD----LFAIKVFN-NISFLRPVDVQMREFEVLKKLNHKNIV 68 ++G G V++G K + AIK + + VD + E ++ + +H NI+ Sbjct: 41 VIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDF-LGEAGIMGQFSHHNII 99 Query: 69 KLFAIEEETTTRHK--VLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 126 +L E +++K ++I E+ G+L L E + + + + +LR + GM +L Sbjct: 100 RL----EGVISKYKPMMIITEYMENGALDKFLREKDGEFSV--LQLVGMLRGIAAGMKYL 153 Query: 127 RENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYE 186 VHRD+ NI+ + V K++DFG +R LEDD + + Y T P + Sbjct: 154 ANMNYVHRDLAARNIL----VNSNLVCKVSDFGLSRVLEDDPE--ATYTTSGGKIPIRW- 206 Query: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVMYKIITG 240 +K+ + D+WS G+ + T G P+ N EVM I G Sbjct: 207 -TAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELS----NHEVMKAINDG 256 >2J0K-A nrPDB Length = 656 Score = 58.9 bits (141), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 63/291 (21%), Positives = 117/291 (40%), Gaps = 57/291 (19%) Query: 11 LSDILGQGATANVFRGRH---KKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNI 67 L +G+G +V +G + + AIK N + + ++E +++ +H +I Sbjct: 394 LGRCIGEGQFGDVHQGIYMSPENPAMAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHI 453 Query: 68 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 127 VKL + E +IME C G L + L+ + L + ++ + + +L Sbjct: 454 VKLIGVITENPV---WIIMELCTLGELRSFLQ--VRKFSLDLASLILYAYQLSTALAYLE 508 Query: 128 ENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTE--EYLHPDMY 185 VHRDI N++ V D KL DFG +R +ED + + G +++ P+ Sbjct: 509 SKRFVHRDIAARNVL-VSATD---CVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESI 564 Query: 186 ERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGA 245 + +++ + D+W GV + + +PF+G + N Sbjct: 565 --------NFRRFTSASDVWMFGVCMWEILMHGV--KPFQGVKNND-------------V 601 Query: 246 ISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFD 296 I ++ E P MP +C P L +++ KCW +D Sbjct: 602 IGRIENGERLP------MPPNCP----------PTLYSLM----TKCWAYD 632 >3PVW-A nrPDB Length = 695 Score = 58.9 bits (141), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 50/219 (22%), Positives = 97/219 (44%), Gaps = 32/219 (14%) Query: 14 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAI 73 I+G+G V+ R TG ++A+K + ++M++ E L LN + ++ L + Sbjct: 196 IIGRGGFGEVYGCRKADTGKMYAMKCLDKKR------IKMKQGETLA-LNERIMLSLVST 248 Query: 74 EEET----------TTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 123 + T I++ G L+ L S E++ +++ G+ Sbjct: 249 GDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHL---SQHGVFSEADMRFYAAEIILGL 305 Query: 124 NHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPD 183 H+ +V+RD+KP NI+ + E G +++D G A + + S+ GT Y+ P+ Sbjct: 306 EHMHNRFVVYRDLKPANIL--LDEHGH--VRISDLGLACDFSKKKPHASV-GTHGYMAPE 360 Query: 184 MYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFR 222 + ++ V Y ++ D +S+G + G PFR Sbjct: 361 VLQKGV-------AYDSSADWFSLGCMLFKLLRGHSPFR 392 >2ZMD-A nrPDB Length = 390 Score = 58.9 bits (141), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 55/219 (25%), Positives = 107/219 (48%), Gaps = 25/219 (11%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFN-NISFLRPVDVQMREFEVLKKLNHKN--IVKLF 71 +G G ++ VF+ ++K ++AIK N + + +D E L KL + I++L+ Sbjct: 64 IGSGGSSKVFQVLNEKK-QIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRLY 122 Query: 72 AIEEETTTRHKVLIMEFCPCGS--LYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN 129 + E T ++ ++ME CG+ L + L++ + + ++++ ++ + ++ Sbjct: 123 --DYEITDQYIYMVME---CGNIDLNSWLKKKKSIDPWERKSYW---KNMLEAVHTIHQH 174 Query: 130 GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFV---SLYGTEEYLHPDMYE 186 GIVH D+KP N + V G + KL DFG A +++ D V S G Y+ P+ + Sbjct: 175 GIVHSDLKPANFLIVDG-----MLKLIDFGIANQMQPDTTSVVKDSQVGAVNYMPPEAIK 229 Query: 187 RAVLRKDH---QKKYGATVDLWSIGVTFYHAATGSLPFR 222 +++ + K D+WS+G Y+ G PF+ Sbjct: 230 DMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ 268 >6DTL-A nrPDB Length = 364 Score = 58.5 bits (140), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 50/201 (24%), Positives = 90/201 (44%), Gaps = 19/201 (9%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHKNIVKLFA 72 +G+GA V + +T + AIK N +F +D + +RE ++L+ ++H+NIV + Sbjct: 38 IGKGAYGIVCSAMNSETNESVAIKKIAN-AFDNKIDAKRTLREIKLLRHMDHENIVAIRD 96 Query: 73 IEEET--TTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 130 I + V I L+ ++ SN L E L ++ G+ ++ Sbjct: 97 IIPPPLRNAFNDVYIAYELMDTDLHQIIR--SNQ-ALSEEHCQYFLYQILRGLKYIHSAN 153 Query: 131 IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVL 190 ++HRD+KP N++ + K+ DFG AR + + T Y P++ + Sbjct: 154 VLHRDLKPSNLLL----NANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNS-- 207 Query: 191 RKDHQKKYGATVDLWSIGVTF 211 Y A +D+WS+G F Sbjct: 208 -----SDYTAAIDVWSVGCIF 223 >2Y6O-A nrPDB Length = 291 Score = 58.2 bits (139), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 56/216 (25%), Positives = 95/216 (43%), Gaps = 24/216 (11%) Query: 14 ILGQGATANVFRGRHKKTGD---LFAIKVFNNISFLRPVDVQMREF----EVLKKLNHKN 66 ++G G V GR K G AIK D Q R+F ++ + +H N Sbjct: 21 VIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGY----TDKQRRDFLSEASIMGQFDHPN 76 Query: 67 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 126 I+ L + T + ++I E+ GSL L + + + + + +LR + GM +L Sbjct: 77 IIHLEGVV--TKCKPVMIITEYMENGSLDAFLRKNDGRFTV--IQLVGMLRGIGSGMKYL 132 Query: 127 RENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYE 186 + VHRD+ NI+ + V K++DFG +R LEDD + + Y T P + Sbjct: 133 SDMSYVHRDLAARNIL----VNSNLVCKVSDFGMSRVLEDDPE--AAYTTRGGKIPIRW- 185 Query: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPF 221 +K+ + D+WS G+ + + G P+ Sbjct: 186 -TAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPY 220 >3OZ6-A nrPDB Length = 388 Score = 57.8 bits (138), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 58/235 (24%), Positives = 101/235 (42%), Gaps = 45/235 (19%) Query: 15 LGQGATANVFRGRHKKTGDLFAIK-VFNNISFLRPVDVQ--MREFEVLKKLN-HKNIVKL 70 LG+GA V++ ++TG++ A+K +F+ +F D Q RE +L +L+ H+NIV L Sbjct: 17 LGKGAYGIVWKSIDRRTGEVVAVKKIFD--AFQNSTDAQRTFREIMILTELSGHENIVNL 74 Query: 71 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 130 + R L+ ++ + T L A L V+ ++ + +L G Sbjct: 75 LNVLRADNDRDVYLVFDY-----METDLHAVIRANILEPVHKQYVVYQLIKVIKYLHSGG 129 Query: 131 IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAAR---------------------ELEDDEQ 169 ++HRD+KP NI+ + + K+ DFG +R +DD+ Sbjct: 130 LLHRDMKPSNILL----NAECHVKVADFGLSRSFVNIRRVTNNIPLSINENTENFDDDQP 185 Query: 170 FVSLY-GTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRP 223 ++ Y T Y P++ + KY +D+WS+G G P P Sbjct: 186 ILTDYVATRWYRAPEILLGST-------KYTKGIDMWSLGCILGEILCGK-PIFP 232 >5UUU-A nrPDB Length = 547 Score = 57.8 bits (138), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 50/219 (22%), Positives = 97/219 (44%), Gaps = 32/219 (14%) Query: 14 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAI 73 I+G+G V+ R TG ++A+K + ++M++ E L LN + ++ L + Sbjct: 205 IIGRGGFGEVYGCRKADTGKMYAMKCLDKKR------IKMKQGETLA-LNERIMLSLVST 257 Query: 74 EEET----------TTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 123 + T I++ G L+ L S E++ +++ G+ Sbjct: 258 GDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHL---SQHGVFSEADMRFYAAEIILGL 314 Query: 124 NHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPD 183 H+ +V+RD+KP NI+ + E G +++D G A + + S+ GT Y+ P+ Sbjct: 315 EHMHNRFVVYRDLKPANIL--LDEHGH--VRISDLGLACDFSKKKPHASV-GTHGYMAPE 369 Query: 184 MYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFR 222 + ++ V Y ++ D +S+G + G PFR Sbjct: 370 VLQKGV-------AYDSSADWFSLGCMLFKLLRGHSPFR 401 >5C26-A nrPDB Length = 299 Score = 57.8 bits (138), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 51/203 (25%), Positives = 93/203 (45%), Gaps = 19/203 (9%) Query: 50 DVQMREFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPE 109 D + E V+++L++ IV++ I E + +L+ME G L L++ + + + Sbjct: 73 DELLAEANVMQQLDNPYIVRMIGICEAESW---MLVMEMAELGPLNKYLQQNRH---VKD 126 Query: 110 SEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQ 169 + ++ V GM +L E+ VHRD+ N++ V Q K++DFG ++ L DE Sbjct: 127 KNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVT----QHYAKISDFGLSKALRADEN 182 Query: 170 FVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHA-ATGSLPFRPFEGPR 228 + T Y + + K+ + D+WS GV + A + G P+R +G Sbjct: 183 YYKA-QTHGKWPVKWYAPECI---NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKG-- 236 Query: 229 RNKEVMYKIITGKPSGAISGVQK 251 EV + G+ G +G + Sbjct: 237 --SEVTAMLEKGERMGCPAGCPR 257 >4NST-A nrPDB Length = 351 Score = 57.8 bits (138), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 55/209 (26%), Positives = 99/209 (47%), Gaps = 29/209 (13%) Query: 14 ILGQGATANVFRGRHKKTGDLFAIKV--FNNISFLRPVDVQMREFEVLKKLNHKNIVKLF 71 I+G+G V++ + K TG+L A+K +N P+ +RE ++L++L H+++V + Sbjct: 20 IIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPI-TAIREIKILRQLIHRSVVNM- 77 Query: 72 AIEEETTTRHKVLIMEFCPCGSLYTVLE-EPSNAYGLPESEFL--------IVLRDVVGG 122 +E T + L + G+ Y V E + GL ES + ++ ++ G Sbjct: 78 --KEIVTDKQDALDFKKDK-GAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEG 134 Query: 123 MNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAAR--ELEDDEQFVSLYGTEEYL 180 + + + +HRDIK NI+ + GQ KL DFG AR E+ + + T Y Sbjct: 135 LEYCHKKNFLHRDIKCSNIL--LNNSGQ--IKLADFGLARLYNSEESRPYTNKVITLWYR 190 Query: 181 HPDMYERAVLRKDHQKKYGATVDLWSIGV 209 P++ +++Y +D+WS G Sbjct: 191 PPELLL-------GEERYTPAIDVWSCGC 212 >5Z33-A nrPDB Length = 425 Score = 57.8 bits (138), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 62/236 (26%), Positives = 105/236 (44%), Gaps = 22/236 (9%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKL-NHKNIVKLF 71 LGQGA V + +T + AIK N+ F + + + +RE ++L+ H+NI L+ Sbjct: 39 LGQGAYGIVCAAVNNQTSEGVAIKKVTNV-FSKKILAKRALREIKLLQHFRGHRNITCLY 97 Query: 72 A--IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN 129 I L E C L ++ + L ++ F + ++ G+ ++ Sbjct: 98 DMDIPRPDNFNETYLYEELMEC-DLAAIIR---SGQPLTDAHFQSFIYQILCGLKYIHSA 153 Query: 130 GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAV 189 ++HRD+KPGN++ + D + K+ DFG AR D + + Y T EY+ Y Sbjct: 154 NVLHRDLKPGNLL--VNADCE--LKICDFGLARGFSVDPEENAGYMT-EYVATRWYRAPE 208 Query: 190 LRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKI--ITGKPS 243 + Q Y +D+WS+G G RPF R + + +I I G P+ Sbjct: 209 IMLSFQ-SYTKAIDVWSVGCILAELLGG----RPFFKGRDYVDQLNQILHILGTPN 259 >2I6L-A nrPDB Length = 320 Score = 57.8 bits (138), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 59/218 (27%), Positives = 95/218 (43%), Gaps = 22/218 (10%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHKNIVKLFA 72 LG G VF AIK I P V+ +RE +++++L+H NIVK+F Sbjct: 19 LGCGGNGLVFSAVDNDCDKRVAIK---KIVLTDPQSVKHALREIKIIRRLDHDNIVKVFE 75 Query: 73 IEEETTTRHKVLIMEFCPCGSLYTVLE--EPSNAYGLPESEFL-----IVLRDVVGGMNH 125 I + ++ + S+Y V E E A L + L + + ++ G+ + Sbjct: 76 ILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLLRGLKY 135 Query: 126 LRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMY 185 + ++HRD+KP N+ + ED V K+ DFG AR + D + E L Y Sbjct: 136 IHSANVLHRDLKPANLF-INTED--LVLKIGDFGLARIM--DPHYSHKGHLSEGLVTKWY 190 Query: 186 E--RAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 R +L ++ Y +D+W+ G F TG F Sbjct: 191 RSPRLLLSPNN---YTKAIDMWAAGCIFAEMLTGKTLF 225 >4OTD-A nrPDB Length = 341 Score = 57.8 bits (138), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 60/214 (28%), Positives = 94/214 (43%), Gaps = 24/214 (11%) Query: 14 ILGQGATANVFRGRHKKTGDLFAIKVF--NNISFLRPVDVQMREFEVLKKL---NHKNIV 68 +LG+G V + +G+LFAIK +I V+ M E +L + H +V Sbjct: 19 VLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTSAGHPFLV 78 Query: 69 KLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE 128 LF + T H +ME+ G L +L S+ + P + F VV G+ L E Sbjct: 79 NLFGCFQ--TPEHVCFVMEYSAGGDL--MLHIHSDVFSEPRAIFYSAC--VVLGLQFLHE 132 Query: 129 NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARE-LEDDEQFVSLYGTEEYLHPDMYER 187 + IV+RD+K N++ + K+ DFG +E + ++ + GT E+L P++ Sbjct: 133 HKIVYRDLKLDNLLLDT----EGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLT- 187 Query: 188 AVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 Y VD W +GV Y G PF Sbjct: 188 -------DTSYTRAVDWWGLGVLLYEMLVGESPF 214 >4HVI-A nrPDB Length = 314 Score = 57.4 bits (137), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 56/206 (27%), Positives = 88/206 (42%), Gaps = 15/206 (7%) Query: 15 LGQGATANVFRGRHKKTGD----LFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKL 70 LG+G +V R+ GD L A+K + + D Q RE ++LK L+ IVK Sbjct: 18 LGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQ-REIQILKALHSDFIVKY 76 Query: 71 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 130 + + L+ME+ P G L L+ + L S L+ + GM +L Sbjct: 77 RGVSYGPGRQSLRLVMEYLPSGCLRDFLQR--HRARLDASRLLLYSSQICKGMEYLGSRR 134 Query: 131 IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVL 190 VHRD+ NI+ + ++ K+ DFG A+ L D+ + + E P + Sbjct: 135 CVHRDLAARNIL----VESEAHVKIADFGLAKLLPLDKDYYVV--REPGQSPIFWYAPES 188 Query: 191 RKDHQKKYGATVDLWSIGVTFYHAAT 216 D+ + D+WS GV Y T Sbjct: 189 LSDN--IFSRQSDVWSFGVVLYELFT 212 >4OW8-A nrPDB Length = 283 Score = 57.4 bits (137), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 59/220 (26%), Positives = 89/220 (40%), Gaps = 22/220 (10%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRP--VDVQMREFEVLKKLNHKN 66 + L ++ G V+ + G A+KV + P ++ E LNH Sbjct: 13 YRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHPG 72 Query: 67 IVKLFAIEEETTT---RHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 123 I + E R L+ME L +VL+ L L +L + Sbjct: 73 IASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGR---LSLRHALDMLEQTGRAL 129 Query: 124 NHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDE--QFVSLYGTEEYLH 181 G+VHRD+KPGNI+ I GQ K+TDFG A+ ++ Q + GT +Y+ Sbjct: 130 QIAHAAGLVHRDVKPGNIL--ITPTGQ--VKITDFGIAKAVDAAPVTQTGMVMGTAQYIA 185 Query: 182 PDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 P+ L D D++S+GV Y A +G PF Sbjct: 186 PEQ----ALGHDASPAS----DVYSLGVVGYEAVSGKRPF 217 >4EWQ-A nrPDB Length = 383 Score = 57.4 bits (137), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 58/230 (25%), Positives = 92/230 (40%), Gaps = 59/230 (25%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQM------REFEVLKKLNHKNIV 68 +G GA +V KTG A+K + RP + RE +LK + H+N++ Sbjct: 53 VGSGAYGSVCAAFDTKTGLRVAVKKLS-----RPFQSIIHAKRTYRELRLLKHMKHENVI 107 Query: 69 KLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAY-----------------GLPESE 111 L + F P SL EE ++ Y L + Sbjct: 108 GLLDV--------------FTPARSL----EEFNDVYLVTHLMGADLNNIVKCQKLTDDH 149 Query: 112 FLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFV 171 ++ ++ G+ ++ I+HRD+KP N+ + ED + K+ DFG AR D++ Sbjct: 150 VQFLIYQILRGLKYIHSADIIHRDLKPSNL--AVNEDCE--LKILDFGLARHT--DDEMT 203 Query: 172 SLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 T Y P++ +L H Y TVD+WS+G TG F Sbjct: 204 GYVATRWYRAPEI----MLNWMH---YNQTVDIWSVGCIMAELLTGRTLF 246 >4FL3-A nrPDB Length = 635 Score = 57.4 bits (137), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 51/203 (25%), Positives = 93/203 (45%), Gaps = 19/203 (9%) Query: 50 DVQMREFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPE 109 D + E V+++L++ IV++ I E + +L+ME G L L++ + + + Sbjct: 415 DELLAEANVMQQLDNPYIVRMIGICEAESW---MLVMEMAELGPLNKYLQQNRH---VKD 468 Query: 110 SEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQ 169 + ++ V GM +L E+ VHRD+ N++ V Q K++DFG ++ L DE Sbjct: 469 KNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVT----QHYAKISDFGLSKALRADEN 524 Query: 170 FVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHA-ATGSLPFRPFEGPR 228 + T Y + + K+ + D+WS GV + A + G P+R +G Sbjct: 525 YYKAQ-THGKWPVKWYAPECI---NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKG-- 578 Query: 229 RNKEVMYKIITGKPSGAISGVQK 251 EV + G+ G +G + Sbjct: 579 --SEVTAMLEKGERMGCPAGCPR 599 >4X3F-A nrPDB Length = 337 Score = 57.4 bits (137), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 59/220 (26%), Positives = 89/220 (40%), Gaps = 22/220 (10%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRP--VDVQMREFEVLKKLNHKN 66 + L ++ G V+ + G A+KV + P ++ E LNH Sbjct: 14 YRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHPG 73 Query: 67 IVKLFAIEEETTT---RHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 123 I + E R L+ME L +VL+ L L +L + Sbjct: 74 IASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGR---LSLRHALDMLEQTGRAL 130 Query: 124 NHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDE--QFVSLYGTEEYLH 181 G+VHRD+KPGNI+ I GQ K+TDFG A+ ++ Q + GT +Y+ Sbjct: 131 QIAHAAGLVHRDVKPGNIL--ITPTGQ--VKITDFGIAKAVDAAPVTQTGMVMGTAQYIA 186 Query: 182 PDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 P+ L D D++S+GV Y A +G PF Sbjct: 187 PEQ----ALGHDASPAS----DVYSLGVVGYEAVSGKRPF 218 >1FVR-A nrPDB Length = 327 Score = 57.4 bits (137), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 61/232 (26%), Positives = 93/232 (40%), Gaps = 39/232 (16%) Query: 11 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKL-NHKNI 67 D++G+G V + R KK G + + D + E EVL KL +H NI Sbjct: 29 FQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNI 88 Query: 68 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEP-------------SNAYGLPESEFLI 114 + L E + L +E+ P G+L L + S A L + L Sbjct: 89 INLLGACEHRG--YLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLH 146 Query: 115 VLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLY 174 DV GM++L + +HRD+ NI+ +GE+ V K+ DFG +R Sbjct: 147 FAADVARGMDYLSQKQFIHRDLAARNIL--VGEN--YVAKIADFGLSR------------ 190 Query: 175 GTEEYLHPDMYERAV----LRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPF 221 G E Y+ M V + + Y D+WS GV + + G P+ Sbjct: 191 GQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPY 242 >6B2Q-A nrPDB Length = 317 Score = 57.4 bits (137), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 59/220 (26%), Positives = 89/220 (40%), Gaps = 22/220 (10%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRP--VDVQMREFEVLKKLNHKN 66 + L ++ G V+ + G A+KV + P ++ E LNH Sbjct: 34 YRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHPG 93 Query: 67 IVKLFAIEEETTT---RHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 123 I + E R L+ME L +VL+ L L +L + Sbjct: 94 IASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGR---LSLRHALDMLEQTGRAL 150 Query: 124 NHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDE--QFVSLYGTEEYLH 181 G+VHRD+KPGNI+ I GQ K+TDFG A+ ++ Q + GT +Y+ Sbjct: 151 QIAHAAGLVHRDVKPGNIL--ITPTGQ--VKITDFGIAKAVDAAPVTQTGMVMGTAQYIA 206 Query: 182 PDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 P+ L D D++S+GV Y A +G PF Sbjct: 207 PEQ----ALGHDASPAS----DVYSLGVVGYEAVSGKRPF 238 >5UIU-A nrPDB Length = 323 Score = 57.0 bits (136), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 51/173 (29%), Positives = 76/173 (43%), Gaps = 25/173 (14%) Query: 54 REFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFL 113 +E +V+ K H+N+V+L + L+ + P GSL L+ S G P + Sbjct: 95 QEIKVMAKCQHENLVELLGFSSDGDDL--CLVYVYMPNGSL---LDRLSCLDGTPPLSWH 149 Query: 114 I---VLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQF 170 + + + G+N L EN +HRDIK NI+ D K++DFG AR E Q Sbjct: 150 MRCKIAQGAANGINFLHENHHIHRDIKSANILL----DEAFTAKISDFGLARASEKFAQT 205 Query: 171 V---SLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLP 220 V + GT Y+ P+ + K D++S GV TG LP Sbjct: 206 VMTSRIVGTTAYMAPEALRGEITPKS---------DIYSFGVVLLEIITG-LP 248 >5GNK-A nrPDB Length = 297 Score = 57.0 bits (136), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 58/214 (27%), Positives = 98/214 (45%), Gaps = 21/214 (9%) Query: 14 ILGQGATANVFRGRHKKTGD----LFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVK 69 +LG GA V++G G+ AIK + + + E V+ +++ ++ + Sbjct: 26 VLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCR 85 Query: 70 LFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLI-VLRDVVGGMNHLRE 128 L I +T + LIM+ P G L + E + G S++L+ + GMN+L + Sbjct: 86 LLGICLTSTVQ---LIMQLMPFGCLLDYVREHKDNIG---SQYLLNWCVQIAKGMNYLED 139 Query: 129 NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERA 188 +VHRD+ N V+ + Q V K+TDFG A+ L +E+ G + + + Sbjct: 140 RRLVHRDLAARN---VLVKTPQHV-KITDFGLAKLLGAEEKEYHAEGGKVPI-----KWM 190 Query: 189 VLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPF 221 L + Y D+WS GVT + T GS P+ Sbjct: 191 ALESILHRIYTHQSDVWSYGVTVWELMTFGSKPY 224 >4G3E-A nrPDB Length = 352 Score = 57.0 bits (136), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 61/220 (27%), Positives = 93/220 (42%), Gaps = 29/220 (13%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 74 +G+G+ V R + K+TG A+K F ++ E L+ IV L+ Sbjct: 82 VGRGSFGEVHRMKDKQTGFQCAVKKVRLEVF------RVEELVACAGLSSPRIVPLYGAV 135 Query: 75 EETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHR 134 E + + ME GSL ++++ LPE L L + G+ +L I+H Sbjct: 136 REGPWVN--IFMELLEGGSLGQLIKQMGC---LPEDRALYYLGQALEGLEYLHTRRILHG 190 Query: 135 DIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLY------GTEEYLHPDMYERA 188 D+K N++ + DG S L DFG A L+ D SL GTE ++ P++ Sbjct: 191 DVKADNVL--LSSDG-SRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPEVV--- 244 Query: 189 VLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF-RPFEGP 227 K A VD+WS H G P+ + F GP Sbjct: 245 -----MGKPCDAKVDIWSSCCMMLHMLNGCHPWTQYFRGP 279 >5AWM-A nrPDB Length = 394 Score = 57.0 bits (136), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 62/240 (25%), Positives = 99/240 (41%), Gaps = 35/240 (14%) Query: 15 LGQGATANVFRGRHKKTGDLFAIK----VFNNISFLRPVDVQMREFEVLKKLNHKNIVKL 70 +G GA V T AIK F N++ + REF+++K +NHKNI+ L Sbjct: 52 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRA---YREFKLMKLVNHKNIIGL 108 Query: 71 FA-------IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 123 +EE + +M+ C + L+ +Y +L ++ G+ Sbjct: 109 LNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMSY---------LLYQMLCGI 159 Query: 124 NHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPD 183 HL GI+HRD+KP NI V+ D K+ DFG AR T Y P+ Sbjct: 160 KHLHSAGIIHRDLKPSNI--VVKAD--CTLKILDFGLARTAGTTFMMTPYVVTRYYRAPE 215 Query: 184 MYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS 243 + +L Y VD+WS+G G + F + + +++ ++ T PS Sbjct: 216 V----IL----GMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPS 267 >4YHJ-A nrPDB Length = 584 Score = 57.0 bits (136), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 54/227 (23%), Positives = 99/227 (43%), Gaps = 19/227 (8%) Query: 14 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQM--REFEVLKKLNHKNIVKL- 70 +LG+G V + + TG ++A K + M E +L+K+ + +V L Sbjct: 192 VLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSRFVVSLA 251 Query: 71 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 130 +A E T L++ G L + N G E + ++ G+ L+ Sbjct: 252 YAYE---TKDALCLVLTIMNGGDLKFHIYNLGNP-GFDEQRAVFYAAELCCGLEDLQRER 307 Query: 131 IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVL 190 IV+RD+KP NI+ D + +++D G A E+ + ++ GT Y+ P++ Sbjct: 308 IVYRDLKPENILL----DDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVV----- 358 Query: 191 RKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKI 237 + +KY + D W +G Y G PF+ ++ + +EV +I Sbjct: 359 ---NNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRI 402 >5TOS-A nrPDB Length = 395 Score = 57.0 bits (136), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 66/222 (29%), Positives = 97/222 (43%), Gaps = 36/222 (16%) Query: 14 ILGQGATANVFRG---------RHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNH 64 ++G+G VF+G TG + A+K N F + + E L +L+H Sbjct: 72 VIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHRE-WLTEINYLGQLSH 130 Query: 65 KNIVKL--FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLI--VLRDVV 120 N+VKL + +E+E H++L+ EF GSL L AY P FL V D Sbjct: 131 PNLVKLIGYCLEDE----HRLLVYEFMQKGSLENHLFR-RGAYFKPLPWFLRVNVALDAA 185 Query: 121 GGMNHLREN--GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELE-DDEQFVS--LYG 175 G+ L + +++RDIK NI+ D KL+DFG AR+ D +VS + G Sbjct: 186 KGLAFLHSDPVKVIYRDIKASNILL----DADYNAKLSDFGLARDGPMGDLSYVSTRVMG 241 Query: 176 TEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATG 217 T Y P+ L A D++S GV +G Sbjct: 242 TYGYAAPEYMSSGHLN--------ARSDVYSFGVLLLEILSG 275 >2BUJ-A nrPDB Length = 317 Score = 56.6 bits (135), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 48/184 (26%), Positives = 83/184 (45%), Gaps = 28/184 (15%) Query: 54 REFEVLKKLNHKNIVKLFA--IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYG-LPES 110 RE ++ + NH NI++L A + E L++ F G+L+ +E + L E Sbjct: 75 READMHRLFNHPNILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFLTED 134 Query: 111 EFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARE----LED 166 + L +L + G+ + G HRD+KP NI+ +G++GQ V L D G+ + +E Sbjct: 135 QILWLLLGICRGLEAIHAKGYAHRDLKPTNIL--LGDEGQPV--LMDLGSMNQACIHVEG 190 Query: 167 DEQFVSLYG------TEEYLHPDMY---ERAVLRKDHQKKYGATVDLWSIGVTFYHAATG 217 Q ++L T Y P+++ V+ + D+WS+G Y G Sbjct: 191 SRQALTLQDWAAQRCTISYRAPELFSVQSHCVIDE--------RTDVWSLGCVLYAMMFG 242 Query: 218 SLPF 221 P+ Sbjct: 243 EGPY 246 >2XS0-A nrPDB Length = 386 Score = 56.6 bits (135), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 49/175 (28%), Positives = 75/175 (42%), Gaps = 28/175 (16%) Query: 54 REFEVLKKLNHKNIVKLF-------AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYG 106 RE ++K +NHKNI+ L ++EE + +M+ C + L+ +Y Sbjct: 74 RELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHERMSY- 132 Query: 107 LPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELED 166 +L ++ G+ HL GI+HRD+KP NI V+ D K+ DFG AR Sbjct: 133 --------LLYQMLCGIKHLHSAGIIHRDLKPSNI--VVKSD--CTLKILDFGLARTAGT 180 Query: 167 DEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 V T Y P++ +L Y VD+WS+G G + F Sbjct: 181 SFMMVPFVVTRYYRAPEV----IL----GMGYKENVDIWSVGCIMGEMIKGGVLF 227 >4E7W-A nrPDB Length = 394 Score = 56.6 bits (135), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 52/221 (23%), Positives = 96/221 (43%), Gaps = 29/221 (13%) Query: 14 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAI 73 ++G G+ VF+ + ++ ++ KV + F + RE ++++ + H N+V L A Sbjct: 47 VIGNGSFGVVFQAKLVESDEVAIKKVLQDKRF------KNRELQIMRIVKHPNVVDLKAF 100 Query: 74 EEETTTRHK----VLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLR----DVVGGMNH 125 + L++E+ P TV + L ++ +++++ ++ + + Sbjct: 101 FYSNGDKKDEVFLNLVLEYVP----ETVYRASRHYAKLKQTMPMLLIKLYMYQLLRSLAY 156 Query: 126 LRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMY 185 + GI HRDIKP N++ + V KL DFG+A+ L E VS + Y P++ Sbjct: 157 IHSIGICHRDIKPQNLLL---DPPSGVLKLIDFGSAKILIAGEPNVSYICSRYYRAPELI 213 Query: 186 ERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEG 226 A Y +D+WS G G P P E Sbjct: 214 FGAT-------NYTTNIDIWSTGCVMAELMQGQ-PLFPGES 246 >2PMN-X nrPDB Length = 348 Score = 56.2 bits (134), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 33/109 (30%), Positives = 56/109 (51%), Gaps = 14/109 (12%) Query: 115 VLRDVVGGMNHL-RENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSL 173 +++ V+ +++ E I HRD+KP NI+ D KL+DFG + E D++ Sbjct: 156 IIKSVLNSFSYIHNEKNICHRDVKPSNILM----DKNGRVKLSDFGES-EYMVDKKIKGS 210 Query: 174 YGTEEYLHPDMYERAVLRKDHQKKY-GATVDLWSIGVTFYHAATGSLPF 221 GT E++ P+ + ++ Y GA VD+WS+G+ Y +PF Sbjct: 211 RGTYEFMPPEFFS-------NESSYNGAKVDIWSLGICLYVMFYNVVPF 252 >3RP9-A nrPDB Length = 458 Score = 55.8 bits (133), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 66/263 (25%), Positives = 106/263 (40%), Gaps = 69/263 (26%) Query: 9 WLLSD------ILGQGATANVFRGRHKKTGDLFAIK----VFNNISFLRPVDVQMREFEV 58 W + D ++G G+ +V K + AIK VF ++ + + +RE + Sbjct: 49 WQIPDRYEIRHLIGTGSYGHVCEAYDKLEKRVVAIKKILRVFEDLIDCKRI---LREIAI 105 Query: 59 LKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYG--------LPES 110 L +LNH ++VK+ I V+ + LY VLE + + L E Sbjct: 106 LNRLNHDHVVKVLDI---------VIPKDVEKFDELYVVLEIADSDFKKLFRTPVYLTEL 156 Query: 111 EFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAAREL------ 164 +L +++ G+ ++ GI+HRD+KP N + + +D K+ DFG AR + Sbjct: 157 HIKTLLYNLLVGVKYVHSAGILHRDLKPANCL--VNQDCS--VKVCDFGLARTVDYPENG 212 Query: 165 ---------EDDEQFVSLYGTEEYLHPDMYERAVLRKDH-------QKKYGATVDLWSIG 208 EDD V+ T+ L + V R Q+ Y +D+WSIG Sbjct: 213 NSQLPISPREDDMNLVTFPHTKN-LKRQLTGHVVTRWYRAPELILLQENYTEAIDVWSIG 271 Query: 209 VTF------------YHAATGSL 219 F YHA G L Sbjct: 272 CIFAELLNMIKENVAYHADRGPL 294 >5LPV-A nrPDB Length = 296 Score = 55.8 bits (133), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 61/221 (27%), Positives = 100/221 (45%), Gaps = 26/221 (11%) Query: 14 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAI 73 ++G G +V++ K G AIK ++S + M E E + K+ H+N+V L Sbjct: 24 LIGSGGFGDVYKAI-LKDGSAVAIKKLIHVSGQGDREF-MAEMETIGKIKHRNLVPLLGY 81 Query: 74 EEETTTRHKVLIMEFCPCGSLYTVLEEPSNA-YGLPESEFLIVLRDVVGGMNHLRENG-- 130 + R +L+ EF GSL VL +P A L S + G+ L N Sbjct: 82 CKVGDER--LLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHHNCSP 139 Query: 131 -IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVS---LYGTEEYLHPDMYE 186 I+HRD+K N++ + E+ ++ +++DFG AR + + +S L GT Y+ P+ Y+ Sbjct: 140 HIIHRDMKSSNVL--LDENLEA--RVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYYQ 195 Query: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGP 227 + D++S GV TG RP + P Sbjct: 196 --------SFRCSTKGDVYSYGVVLLELLTGK---RPTDSP 225 >2DQ7-X nrPDB Length = 283 Score = 55.8 bits (133), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 49/190 (25%), Positives = 89/190 (46%), Gaps = 21/190 (11%) Query: 53 MREFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEE-PSNAYGLPESE 111 + E +++KKL H +V+L+A+ E ++ E+ GSL L++ A LP Sbjct: 52 LEEAQIMKKLKHDKLVQLYAVVSEEPI---YIVTEYMNKGSLLDFLKDGEGRALKLP--N 106 Query: 112 FLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFV 171 + + V GM ++ +HRD++ NI+ G + K+ DFG AR +ED+E + Sbjct: 107 LVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNG----LICKIADFGLARLIEDNE-YT 161 Query: 172 SLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRN 230 + G + + E A+ ++ D+WS G+ T G +P+ N Sbjct: 162 ARQGAKFPIKWTAPEAALY-----GRFTIKSDVWSFGILLTELVTKGRVPYPGM----NN 212 Query: 231 KEVMYKIITG 240 +EV+ ++ G Sbjct: 213 REVLEQVERG 222 >5LPZ-A nrPDB Length = 332 Score = 55.5 bits (132), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 61/221 (27%), Positives = 96/221 (43%), Gaps = 26/221 (11%) Query: 14 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAI 73 ++G G +V++ K G AIK ++S + M E E + K+ H+N+V L Sbjct: 24 LIGSGGFGDVYKAI-LKDGSAVAIKKLIHVSGQGDREF-MAEMETIGKIKHRNLVPLLGY 81 Query: 74 EEETTTRHKVLIMEFCPCGSLYTVLEEPSNA-YGLPESEFLIVLRDVVGGMNHLRENG-- 130 + R +L+ EF GSL VL +P A L S + G+ L N Sbjct: 82 CKVGDER--LLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHHNCSP 139 Query: 131 -IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVS---LYGTEEYLHPDMYE 186 I+HRD+K N++ D +++DFG AR + + +S L GT Y+ P+ Y+ Sbjct: 140 HIIHRDMKSSNVLL----DENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYYQ 195 Query: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGP 227 + D++S GV TG RP + P Sbjct: 196 SF--------RCSTKGDVYSYGVVLLELLTGK---RPTDSP 225 >3I81-A nrPDB Length = 315 Score = 55.5 bits (132), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 63/242 (26%), Positives = 108/242 (44%), Gaps = 26/242 (10%) Query: 11 LSDILGQGATANVFRGRHK-----KTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHK 65 +S LGQG+ V+ G K + AIK N + +R + E V+K+ N Sbjct: 22 MSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCH 81 Query: 66 NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVL-----EEPSNAYGLPES--EFLIVLRD 118 ++V+L + + + ++IME G L + L E +N P S + + + + Sbjct: 82 HVVRLLGVV--SQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGE 139 Query: 119 VVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEE 178 + GM +L N VHRD+ N M + ED K+ DFG R++ + + + G + Sbjct: 140 IADGMAYLNANKFVHRDLAARNCM--VAED--FTVKIGDFGMTRDIYETDYYRK--GGKG 193 Query: 179 YLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKII 238 L L+ Y D+WS GV + AT L +P++G N++V+ ++ Sbjct: 194 LLPVRWMSPESLKDGVFTTYS---DVWSFGVVLWEIAT--LAEQPYQG-LSNEQVLRFVM 247 Query: 239 TG 240 G Sbjct: 248 EG 249 >5IKW-A nrPDB Length = 310 Score = 55.1 bits (131), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 66/236 (27%), Positives = 101/236 (42%), Gaps = 31/236 (13%) Query: 3 STSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIK--VFNNISFLRPVDVQMREFEVLK 60 + H L + L +G + VF R G A+K NN+ L +V RE ++K Sbjct: 10 AVGRHQVTLEESLAEGGFSTVFLVR-THGGIRCALKRMYVNNMPDL---NVCKREITIMK 65 Query: 61 KLN-HKNIVKLF--AIEEETTTRHKVLI-MEFCPCGSLYTVLEEPSNAYGLPESEFLIVL 116 +L+ HKNIV A+ + +VLI ME+C G + + + G E E L + Sbjct: 66 ELSGHKNIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQT-GFTEPEVLQIF 124 Query: 117 RDVVGGMNHLRE--NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARE---------LE 165 D + L + I+HRD+K NI+ DG + Y L DFG+A + Sbjct: 125 CDTCEAVARLHQCKTPIIHRDLKVENILL---NDGGN-YVLCDFGSATNKFLNPQKDGVN 180 Query: 166 DDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 E+ + Y T Y P+M + K D+W++G Y +LPF Sbjct: 181 VVEEEIKKYTTLSYRAPEM-----INLYGGKPITTKADIWALGCLLYKLCFFTLPF 231 >5U6C-A nrPDB Length = 315 Score = 55.1 bits (131), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 56/230 (24%), Positives = 101/230 (43%), Gaps = 28/230 (12%) Query: 7 HLWLLSDILGQGATANVFRGRHKK---TGDLFAIKVFN-NISFLRPVDVQMREFEVLKKL 62 +L +L ILG+G +V G K+ T A+K + S R ++ + E +K Sbjct: 36 NLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDF 95 Query: 63 NHKNIVKLFAIEEETTTR---HKVLIMEFCPCGSLYTVLEEPSNAYG---LPESEFLIVL 116 +H N+++L + E +++ ++I+ F G L+T L G +P L + Sbjct: 96 SHPNVMRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFM 155 Query: 117 RDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGT 176 D+ GM +L +HRD+ N M D +V + DFG +++ +Y Sbjct: 156 VDIALGMEYLSNRNFLHRDLAARNCML---RDDMTVC-VADFGLSKK---------IYSG 202 Query: 177 EEYLHPDMYERAV----LRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPF 221 + Y + + V + + Y + D+W+ GVT + AT G P+ Sbjct: 203 DYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPY 252 >3FI2-A nrPDB Length = 353 Score = 55.1 bits (131), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 46/159 (28%), Positives = 67/159 (42%), Gaps = 22/159 (13%) Query: 54 REFEVLKKLNHKNIVKLFAIEEETTTRHKV----LIMEFCPCGSLYTVLEEPSNAYGLPE 109 RE ++K +NHKNI+ L + T + L+ME + E L Sbjct: 72 RELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME------LDH 125 Query: 110 SEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQ 169 +L ++ G+ HL GI+HRD+KP NI V+ D K+ DFG AR Sbjct: 126 ERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNI--VVKSD--CTLKILDFGLARTAGTSFM 181 Query: 170 FVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIG 208 T Y P++ +L Y VD+WS+G Sbjct: 182 MTPYVVTRYYRAPEV----IL----GMGYKENVDIWSVG 212 >3LMG-A nrPDB Length = 344 Score = 54.7 bits (130), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 58/214 (27%), Positives = 92/214 (42%), Gaps = 21/214 (9%) Query: 14 ILGQGATANVFRGRHKKTGDLF----AIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVK 69 +LG G V +G G+ IKV + S + + L+H +IV+ Sbjct: 38 VLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVR 97 Query: 70 LFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN 129 L + ++ + L+ ++ P GSL + + A G L + GM +L E+ Sbjct: 98 LLGLCPGSSLQ---LVTQYLPLGSLLDHVRQHRGALG--PQLLLNWGVQIAKGMYYLEEH 152 Query: 130 GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAAREL-EDDEQFVSLYGTEEYLHPDMYERA 188 G+VHR++ N++ S ++ DFG A L DD+Q LY E P + Sbjct: 153 GMVHRNLAARNVLL----KSPSQVQVADFGVADLLPPDDKQL--LY--SEAKTPIKW--M 202 Query: 189 VLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPF 221 L H KY D+WS GVT + T G+ P+ Sbjct: 203 ALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPY 236 >5ZTN-A nrPDB Length = 429 Score = 54.7 bits (130), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 59/259 (22%), Positives = 114/259 (44%), Gaps = 19/259 (7%) Query: 14 ILGQGATANVFRGRHKKTGDLFAIK-VFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFA 72 ++G+G+ V + K A+K V N F R ++R E L+K + N + + Sbjct: 104 VIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIH 163 Query: 73 IEEETTTRHKVLIMEFCPCGSLYTVLEEPS-NAYGLPESEFLIVLRDVVGGMNHLRENGI 131 + E T R+ + + +LY ++++ + LP ++ ++ L +N I Sbjct: 164 MLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFA--HSILQCLDALHKNRI 221 Query: 132 VHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLR 191 +H D+KP NI+ + + G+S K+ DFG++ + ++ + + Y P++ A Sbjct: 222 IHCDLKPENIL--LKQQGRSGIKVIDFGSS--CYEHQRVYTYIQSRFYRAPEVILGA--- 274 Query: 192 KDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQK 251 +YG +D+WS+G TG P P E M +++ G PS + K Sbjct: 275 -----RYGMPIDMWSLGCILAELLTG-YPLLPGEDEGDQLACMIELL-GMPSQKLLDASK 327 Query: 252 AENGPIDWSGDMPVSCSLS 270 + G P C+++ Sbjct: 328 RAKNFVSSKG-YPRYCTVT 345 >4M7I-A nrPDB Length = 299 Score = 54.7 bits (130), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 53/221 (23%), Positives = 89/221 (40%), Gaps = 35/221 (15%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 74 LG+G VF ++K +AIK + + MRE + L KL H IV+ F Sbjct: 13 LGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAW 72 Query: 75 EETTTRHKV----------LIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 124 E T K+ + M+ C +L + S L + + + Sbjct: 73 LEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVE 132 Query: 125 HLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLY---------- 174 L G++HRD+KP NI + + V K+ DFG ++ DE+ ++ Sbjct: 133 FLHSKGLMHRDLKPSNIFFTMDD----VVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHT 188 Query: 175 ---GTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFY 212 GT+ Y+ P+ + H Y VD++S+G+ + Sbjct: 189 GQVGTKLYMSPE--------QIHGNSYSHKVDIFSLGLILF 221 >1K9A-A nrPDB Length = 450 Score = 54.7 bits (130), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 56/213 (26%), Positives = 96/213 (45%), Gaps = 24/213 (11%) Query: 11 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKL 70 L +G+G +V G ++ G+ A+K N + + + E V+ +L H N+V+L Sbjct: 197 LLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQAF---LAEASVMTQLRHSNLVQL 251 Query: 71 FA-IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN 129 I EE + ++ E+ GSL L + L L DV M +L N Sbjct: 252 LGVIVEEKGGLY--IVTEYMAKGSLVDYLRSRGRSV-LGGDCLLKFSLDVCEAMEYLEGN 308 Query: 130 GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAV 189 VHRD+ N++ + ED +V K++DFG +E + L ++ P+ Sbjct: 309 NFVHRDLAARNVL--VSED--NVAKVSDFGLTKEASSTQDTGKL--PVKWTAPE-----A 357 Query: 190 LRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPF 221 LR +KK+ D+WS G+ + + G +P+ Sbjct: 358 LR---EKKFSTKSDVWSFGILLWEIYSFGRVPY 387 >1JNK-A nrPDB Length = 423 Score = 54.7 bits (130), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 46/159 (28%), Positives = 67/159 (42%), Gaps = 22/159 (13%) Query: 54 REFEVLKKLNHKNIVKLFAIEEETTTRHKV----LIMEFCPCGSLYTVLEEPSNAYGLPE 109 RE ++K +NHKNI+ L + T + L+ME + E L Sbjct: 110 RELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME------LDH 163 Query: 110 SEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQ 169 +L ++ G+ HL GI+HRD+KP NI V+ D K+ DFG AR Sbjct: 164 ERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNI--VVKSD--CTLKILDFGLARTAGTSFM 219 Query: 170 FVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIG 208 T Y P++ +L Y VD+WS+G Sbjct: 220 MTPYVVTRYYRAPEV----ILGMG----YKENVDIWSVG 250 >3LZB-A nrPDB Length = 327 Score = 54.7 bits (130), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 57/214 (26%), Positives = 97/214 (45%), Gaps = 21/214 (9%) Query: 14 ILGQGATANVFRGRHKKTGD----LFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVK 69 +LG GA V++G G+ AIK + + + E V+ +++ ++ + Sbjct: 22 VLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCR 81 Query: 70 LFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLI-VLRDVVGGMNHLRE 128 L I +T + LI + P G L + E + G S++L+ + GMN+L + Sbjct: 82 LLGICLTSTVQ---LITQLMPFGCLLDYVREHKDNIG---SQYLLNWCVQIAKGMNYLED 135 Query: 129 NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERA 188 +VHRD+ N V+ + Q V K+TDFG A+ L +E+ G + + + Sbjct: 136 RRLVHRDLAARN---VLVKTPQHV-KITDFGLAKLLGAEEKEYHAEGGKVPI-----KWM 186 Query: 189 VLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPF 221 L + Y D+WS GVT + T GS P+ Sbjct: 187 ALESILHRIYTHQSDVWSYGVTVWELMTFGSKPY 220 >1BYG-A nrPDB Length = 278 Score = 54.7 bits (130), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 56/213 (26%), Positives = 96/213 (45%), Gaps = 24/213 (11%) Query: 11 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKL 70 L +G+G +V G ++ G+ A+K N + + + E V+ +L H N+V+L Sbjct: 25 LLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQAF---LAEASVMTQLRHSNLVQL 79 Query: 71 FA-IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN 129 I EE + ++ E+ GSL L + L L DV M +L N Sbjct: 80 LGVIVEEKGGLY--IVTEYMAKGSLVDYLRSRGRSV-LGGDCLLKFSLDVCEAMEYLEGN 136 Query: 130 GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAV 189 VHRD+ N++ + ED +V K++DFG +E + L ++ P+ Sbjct: 137 NFVHRDLAARNVL--VSED--NVAKVSDFGLTKEASSTQDTGKL--PVKWTAPE-----A 185 Query: 190 LRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPF 221 LR +KK+ D+WS G+ + + G +P+ Sbjct: 186 LR---EKKFSTKSDVWSFGILLWEIYSFGRVPY 215 >3LLT-A nrPDB Length = 360 Score = 54.7 bits (130), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 62/246 (25%), Positives = 100/246 (40%), Gaps = 42/246 (17%) Query: 6 NHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNIS-FLRPVDVQMREFEVLKKLNH 64 N+ +L+ +G G V +H +A+KV NI + R + E ++LKK+ + Sbjct: 34 NNAFLVIRKMGDGTFGRVLLCQHIDNKKYYAVKVVRNIKKYTRSAKI---EADILKKIQN 90 Query: 65 KNIVKLFAIEEE---TTTRHKVLIMEFCPCG-SLYTVLEEPSNAYGLPESEFLIVLRDVV 120 +I ++ H LI E P G SLY ++ +N G + + +++ Sbjct: 91 DDINNNNIVKYHGKFMYYDHMCLIFE--PLGPSLYEIITR-NNYNGFHIEDIKLYCIEIL 147 Query: 121 GGMNHLRENGIVHRDIKPGNIM--------------RVIGEDGQSVY-------KLTDFG 159 +N+LR+ + H D+KP NI+ RV +Y KL DFG Sbjct: 148 KALNYLRKMSLTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTKSTGIKLIDFG 207 Query: 160 AARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSL 219 A D S+ T +Y P++ + + D+WS G TGSL Sbjct: 208 CATFKSDYHG--SIINTRQYRAPEVILNL--------GWDVSSDMWSFGCVLAELYTGSL 257 Query: 220 PFRPFE 225 FR E Sbjct: 258 LFRTHE 263 >1LUF-A nrPDB Length = 343 Score = 54.7 bits (130), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 77/312 (24%), Positives = 127/312 (40%), Gaps = 70/312 (22%) Query: 6 NHLWLLSDILGQGATANVFRGRHK-----KTGDLFAIKVFNN-ISFLRPVDVQMREFEVL 59 N++ + DI G+GA VF+ R + + A+K+ S D Q RE ++ Sbjct: 47 NNIEYVRDI-GEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQ-REAALM 104 Query: 60 KKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPS----------------- 102 + ++ NIVKL + + L+ E+ G L L S Sbjct: 105 AEFDNPNIVKLLGVC--AVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRAR 162 Query: 103 -NAYGLPE---SEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDF 158 ++ G P +E L + R V GM +L E VHRD+ N + +GE+ V K+ DF Sbjct: 163 VSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCL--VGEN--MVVKIADF 218 Query: 159 GAARELEDDEQFVSLYGTEEYLHPDMYERAVLR-----KDHQKKYGATVDLWSIGVTFYH 213 G +R + + +Y D + +R +Y D+W+ GV + Sbjct: 219 GLSRNIY----------SADYYKADGNDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWE 268 Query: 214 AATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGPID--------WS---GD 262 + L +P+ G ++EV+Y + G + + EN P++ WS D Sbjct: 269 IFSYGL--QPYYG-MAHEEVIYYVRDG------NILACPENCPLELYNLMRLCWSKLPAD 319 Query: 263 MPVSCSLSRGLQ 274 P CS+ R LQ Sbjct: 320 RPSFCSIHRILQ 331 >2HK5-A nrPDB Length = 270 Score = 54.3 bits (129), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 54/217 (24%), Positives = 89/217 (41%), Gaps = 24/217 (11%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 74 LG G V+ + K + A+K S V+ + E V+K L H +VKL A+ Sbjct: 23 LGAGQFGEVWMATYNKHTKV-AVKTMKPGSM--SVEAFLAEANVMKTLQHDKLVKLHAV- 78 Query: 75 EETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHR 134 T +I EF GSL L+ + P + + + GM + + +HR Sbjct: 79 --VTKEPIYIITEFMAKGSLLDFLKSDEGS-KQPLPKLIDFSAQIAEGMAFIEQRNYIHR 135 Query: 135 DIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTE---EYLHPDMYERAVLR 191 D++ NI+ V K+ DFG AR +ED+E + + G + ++ P+ Sbjct: 136 DLRAANILV----SASLVCKIADFGLARVIEDNE-YTAREGAKFPIKWTAPEAINFG--- 187 Query: 192 KDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGP 227 + D+WS G+ T G +P+ P Sbjct: 188 -----SFTIKSDVWSFGILLMEIVTYGRIPYPGMSNP 219 >4IDT-A nrPDB Length = 356 Score = 54.3 bits (129), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 63/220 (28%), Positives = 90/220 (40%), Gaps = 29/220 (13%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 74 LG+G+ V R K+TG A+K F + E L IV L+ Sbjct: 82 LGRGSFGEVHRMEDKQTGFQCAVKKVRLEVF------RAEELMACAGLTSPRIVPLYGAV 135 Query: 75 EETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHR 134 E + + ME GSL +++E LPE L L + G+ +L I+H Sbjct: 136 REGPWVN--IFMELLEGGSLGQLVKEQGC---LPEDRALYYLGQALEGLEYLHSRRILHG 190 Query: 135 DIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLY------GTEEYLHPDMYERA 188 D+K N++ + DG S L DFG A L+ D L GTE ++ P++ Sbjct: 191 DVKADNVL--LSSDG-SHAALCDFGHAVCLQPDGLGKDLLTGDYIPGTETHMAPEV---- 243 Query: 189 VLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRP-FEGP 227 VL + K VD+WS H G P+ F GP Sbjct: 244 VLGRSCDAK----VDVWSSCCMMLHMLNGCHPWTQFFRGP 279 >3FME-A nrPDB Length = 290 Score = 53.9 bits (128), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 55/233 (23%), Positives = 89/233 (38%), Gaps = 48/233 (20%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNI-------SFLRPVDVQMREFEVLKKLNHKNI 67 LG+GA V + RH +G + A+K L +D+ MR + Sbjct: 15 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDC--------- 65 Query: 68 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYG------------LPESEFLIV 115 T T + L E G ++ +E + +PE + Sbjct: 66 -------PFTVTFYGALFRE----GDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKI 114 Query: 116 LRDVVGGMNHLREN-GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLY 174 +V + HL ++HRD+KP N++ I GQ K+ DFG + L DD Sbjct: 115 AVSIVKALEHLHSKLSVIHRDVKPSNVL--INALGQ--VKMCDFGISGYLVDDVAKDIDA 170 Query: 175 GTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGP 227 G + Y+ P+ + +QK Y D+WS+G+T A P+ + P Sbjct: 171 GCKPYMAPERINPEL----NQKGYSVKSDIWSLGITMIELAILRFPYDSWGTP 219 >2RIO-A nrPDB Length = 434 Score = 53.9 bits (128), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 56/229 (24%), Positives = 106/229 (46%), Gaps = 31/229 (13%) Query: 14 ILGQGATANV-FRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLN-HKNIVKLF 71 ILG G++ V F+G + G A+K + D+ + E ++L + + H N+++ + Sbjct: 22 ILGYGSSGTVVFQGSFQ--GRPVAVKRM----LIDFCDIALMEIKLLTESDDHPNVIRYY 75 Query: 72 AIEEETTTRHKVLIMEFCPCGSLYTVLEEPS----NAYGLPESEFLIVLRDVVGGMNHLR 127 ETT R + +E C +L ++E + N E + +LR + G+ HL Sbjct: 76 C--SETTDRFLYIALELCNL-NLQDLVESKNVSDENLKLQKEYNPISLLRQIASGVAHLH 132 Query: 128 ENGIVHRDIKPGNIM-----RVIGEDGQSVYKL----TDFGAARELEDDE-----QFVSL 173 I+HRD+KP NI+ R + L +DFG ++L+ + + Sbjct: 133 SLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRTNLNNP 192 Query: 174 YGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHA-ATGSLPF 221 GT + P++ E + +++ ++D++S+G FY+ + G PF Sbjct: 193 SGTSGWRAPELLEESN-NLQTKRRLTRSIDIFSMGCVFYYILSKGKHPF 240 >3QUP-A nrPDB Length = 323 Score = 53.5 bits (127), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 56/242 (23%), Positives = 101/242 (41%), Gaps = 25/242 (10%) Query: 11 LSDILGQGATANVFRGRHKKTGDLF---AIKVFN-NISFLRPVDVQMREFEVLKKLNHKN 66 L +LG+G +V + K+ F A+K+ +I ++ +RE +K+ +H + Sbjct: 27 LGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPH 86 Query: 67 IVKLFAIEEETTTRHKV----LIMEFCPCGSLYTVLEEP---SNAYGLPESEFLIVLRDV 119 + KL + + + ++ +I+ F G L+ L N + LP + + D+ Sbjct: 87 VAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLVRFMVDI 146 Query: 120 VGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEY 179 GM +L +HRD+ N M + ED + DFG +R++ + + G Sbjct: 147 ACGMEYLSSRNFIHRDLAARNCM--LAED--MTVCVADFGLSRKIYSGDYYRQ--GCASK 200 Query: 180 LHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVMYKII 238 L + L Y D+W+ GVT + T G P+ E N E+ +I Sbjct: 201 LP---VKWLALESLADNLYTVHSDVWAFGVTMWEIMTRGQTPYAGIE----NAEIYNYLI 253 Query: 239 TG 240 G Sbjct: 254 GG 255 >6NPU-A nrPDB Length = 298 Score = 53.1 bits (126), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 53/214 (24%), Positives = 91/214 (42%), Gaps = 21/214 (9%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 74 LG G V+ G KK A+K + V+ ++E V+K++ H N+V+L + Sbjct: 34 LGGGQYGEVYEGVWKKYSLTVAVKTLKEDTM--EVEEFLKEAAVMKEIKHPNLVQLLGV- 90 Query: 75 EETTTRHK--VLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIV 132 TR +I EF G+L L E N + L + + M +L + + Sbjct: 91 ---CTREPPFYIITEFMTYGNLLDYLRE-CNRQEVNAVVLLYMATQISSAMEYLEKKNFI 146 Query: 133 HRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRK 192 HRD+ N + +GE+ + K+ DFG +R + D + + G + + E Sbjct: 147 HRDLAARNCL--VGEN--HLVKVADFGLSRLMTGD-TYTAHAGAKFPIKWTAPESLAYN- 200 Query: 193 DHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEG 226 K+ D+W+ GV + AT + P+ G Sbjct: 201 ----KFSIKSDVWAFGVLLWEIATYGM--SPYPG 228 >3GC0-A nrPDB Length = 329 Score = 53.1 bits (126), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 53/200 (26%), Positives = 89/200 (44%), Gaps = 16/200 (8%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVD-VQMREFEVLKKLNHKNIVKLFAI 73 LG+G V++ T + AIK V +RE +LK+L H+NI++L ++ Sbjct: 42 LGEGTYGEVYKAIDTVTNETVAIKRIRLEHEEEGVPGTAIREVSLLKELQHRNIIELKSV 101 Query: 74 EEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVH 133 H LI E+ + + P + + +S L ++ G+N +H Sbjct: 102 IHHNHRLH--LIFEYAENDLKKYMDKNPDVSMRVIKS----FLYQLINGVNFCHSRRCLH 155 Query: 134 RDIKPGNIMRVIGEDGQS-VYKLTDFGAARELE-DDEQFVSLYGTEEYLHPDMYERAVLR 191 RD+KP N++ + + ++ V K+ DFG AR QF T Y P++ +L Sbjct: 156 RDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQFTHEIITLWYRPPEI----LLG 211 Query: 192 KDHQKKYGATVDLWSIGVTF 211 H Y +VD+WSI + Sbjct: 212 SRH---YSTSVDIWSIACIW 228 >4AT3-A nrPDB Length = 299 Score = 53.1 bits (126), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 64/262 (24%), Positives = 111/262 (42%), Gaps = 42/262 (16%) Query: 1 MQSTSNHLWLLSDILGQGATANVFRGR-----HKKTGDLFAIKVFNNISFLRPVDVQMRE 55 +Q H +L LG+GA VF ++ L A+K + S D RE Sbjct: 7 VQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFH-RE 65 Query: 56 FEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSL----------YTVLEEPSNAY 105 E+L L H++IVK + + E +++ E+ G L ++ E + Sbjct: 66 AELLTNLQHEHIVKFYGVCVEGDPL--IMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPT 123 Query: 106 GLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELE 165 L +S+ L + + + GM +L VHRD+ N + +GE+ + K+ DFG +R++ Sbjct: 124 ELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCL--VGEN--LLVKIGDFGMSRDVY 179 Query: 166 DDEQFVSLYGTE---EYLHPD--MYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSL 219 + + T ++ P+ MY +K+ D+WS+GV + T G Sbjct: 180 STDYYRVGGHTMLPIRWMPPESIMY----------RKFTTESDVWSLGVVLWEIFTYGKQ 229 Query: 220 PFRPFEGPRRNKEVMYKIITGK 241 P+ N EV+ I G+ Sbjct: 230 PWYQLS----NNEVIECITQGR 247 >2OGV-A nrPDB Length = 317 Score = 52.8 bits (125), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 62/241 (25%), Positives = 98/241 (40%), Gaps = 35/241 (14%) Query: 15 LGQGATANVFR----GRHKKTGDL-FAIKVFNNISFLRPVDVQMREFEVLKKLN-HKNIV 68 LG GA V G K+ L A+K+ + + + M E +++ L H+NIV Sbjct: 46 LGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIV 105 Query: 69 KLFAIEEETTTRHKVLIM-EFCPCGSLYTVLEEPSNAYGLPESEFLIVLRD-------VV 120 L T VL++ E+C G L L + A E + LRD V Sbjct: 106 NLLG---ACTHGGPVLVITEYCCYGDLLNFLRRKAEADLDKEDGRPLELRDLLHFSSQVA 162 Query: 121 GGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTE--- 177 GM L +HRD+ N++ G V K+ DFG AR++ +D ++ Sbjct: 163 QGMAFLASKNCIHRDVAARNVLLTNGH----VAKIGDFGLARDIMNDSNYIVKGNARLPV 218 Query: 178 EYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKI 237 +++ P+ V Y D+WS G+ + SL P+ G N + YK+ Sbjct: 219 KWMAPESIFDCV--------YTVQSDVWSYGILLWE--IFSLGLNPYPGILVNSK-FYKL 267 Query: 238 I 238 + Sbjct: 268 V 268 >5FM2-A nrPDB Length = 355 Score = 52.8 bits (125), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 59/241 (24%), Positives = 99/241 (41%), Gaps = 42/241 (17%) Query: 10 LLSDILGQG-------ATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKL 62 +L LG+G ATA +GR T A+K+ + + + EF VLK++ Sbjct: 67 VLGKTLGEGEFGKVVKATAFHLKGRAGYT--TVAVKMLKENASPSELRDLLSEFNVLKQV 124 Query: 63 NHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEP--------------------- 101 NH +++KL+ + +LI+E+ GSL L E Sbjct: 125 NHPHVIKLYGACSQDGPL--LLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDH 182 Query: 102 SNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAA 161 + L + + + GM +L E +VHRD+ NI+ G K++DFG + Sbjct: 183 PDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRK----MKISDFGLS 238 Query: 162 RELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLP 220 R++ +++ +V + P + DH Y D+WS GV + T G P Sbjct: 239 RDVYEEDSYVK---RSQGRIPVKWMAIESLFDHI--YTTQSDVWSFGVLLWEIVTLGGNP 293 Query: 221 F 221 + Sbjct: 294 Y 294 >4XEY-B nrPDB Length = 408 Score = 52.4 bits (124), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 53/214 (24%), Positives = 91/214 (42%), Gaps = 21/214 (9%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 74 LG G V+ G KK A+K + V+ ++E V+K++ H N+V+L + Sbjct: 133 LGGGQYGEVYEGVWKKYSLTVAVKTLKEDTM--EVEEFLKEAAVMKEIKHPNLVQLLGV- 189 Query: 75 EETTTRHK--VLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIV 132 TR +I EF G+L L E N + L + + M +L + + Sbjct: 190 ---CTREPPFYIITEFMTYGNLLDYLRE-CNRQEVNAVVLLYMATQISSAMEYLEKKNFI 245 Query: 133 HRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRK 192 HRD+ N + +GE+ + K+ DFG +R + D + + G + + E Sbjct: 246 HRDLAARNCL--VGEN--HLVKVADFGLSRLMTGD-TYTAHAGAKFPIKWTAPESLAY-- 298 Query: 193 DHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEG 226 K+ D+W+ GV + AT + P+ G Sbjct: 299 ---NKFSIKSDVWAFGVLLWEIATYGM--SPYPG 327 >5X8I-B nrPDB Length = 346 Score = 52.4 bits (124), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 74/308 (24%), Positives = 121/308 (39%), Gaps = 50/308 (16%) Query: 11 LSDILGQGATANVFRG-RHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVK 69 + D LG+GA V HK G A+K+ N+ R + E +VL+ LN Sbjct: 17 IVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVD--RYCEAARSEIQVLEHLN------ 68 Query: 70 LFAIEEETTTRHKVLIMEFCPCGSLYTVLE--EPSNAYGLPESEFLIVLRD--------V 119 + +T R ++ F G + V E S + E+ FL D + Sbjct: 69 --TTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQI 126 Query: 120 VGGMNHLRENGIVHRDIKPGNIMRV-----------IGEDGQSV----YKLTDFGAAREL 164 +N L N + H D+KP NI+ V I D +++ K+ DFG+A Sbjct: 127 CKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSA--T 184 Query: 165 EDDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPF 224 DDE +L T Y P++ +L + D+WSIG G F P Sbjct: 185 YDDEHHSTLVSTRHYRAPEV----IL----ALGWSQPCDVWSIGCILIEYYLGFTVF-PT 235 Query: 225 EGPRRNKEVMYKIITGKPSGAISGVQKAE---NGPIDWSGDMPVSCSLSRGLQVLLTPVL 281 + + +M +I+ P I +K + + +DW +SR + L +L Sbjct: 236 HDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFML 295 Query: 282 ANILEADQ 289 + +E ++ Sbjct: 296 SQDVEHER 303 >3VN9-A nrPDB Length = 340 Score = 52.4 bits (124), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 54/233 (23%), Positives = 88/233 (37%), Gaps = 48/233 (20%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNI-------SFLRPVDVQMREFEVLKKLNHKNI 67 LG+GA V + RH +G + A+K L +D+ MR + Sbjct: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDC--------- 109 Query: 68 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYG------------LPESEFLIV 115 T T + L E G ++ +E + +PE + Sbjct: 110 -------PFTVTFYGALFRE----GDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKI 158 Query: 116 LRDVVGGMNHLREN-GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLY 174 +V + HL ++HRD+KP N++ I GQ K+ DFG + L D Sbjct: 159 AVSIVKALEHLHSKLSVIHRDVKPSNVL--INALGQ--VKMCDFGISGYLVDSVAKTIDA 214 Query: 175 GTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGP 227 G + Y+ P+ + +QK Y D+WS+G+T A P+ + P Sbjct: 215 GCKPYMAPERINPEL----NQKGYSVKSDIWSLGITMIELAILRFPYDSWGTP 263 >5USZ-A nrPDB Length = 289 Score = 52.4 bits (124), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 64/287 (22%), Positives = 120/287 (41%), Gaps = 32/287 (11%) Query: 10 LLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFE--------VLKK 61 + ++ LGQG +F+G ++ GD ++ L+ +D R + ++ K Sbjct: 11 IFNESLGQGTFTKIFKGVRREVGDYG--QLHETEVLLKVLDKAHRNYSESFFEAASMMSK 68 Query: 62 LNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVG 121 L+HK++V + + +L+ EF GSL T L++ N + L V + + Sbjct: 69 LSHKHLVLNYGVC--VCGDENILVQEFVKFGSLDTYLKKNKNCINILWK--LEVAKQLAA 124 Query: 122 GMNHLRENGIVHRDIKPGNIMRVIGEDGQS----VYKLTDFGAARELEDDEQFVSLYGTE 177 M+ L EN ++H ++ NI+ + ED ++ KL+D G + + + L Sbjct: 125 AMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKD---ILQERI 181 Query: 178 EYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGS-LPFRPFEGPRRNKEVMYK 236 ++ P+ E + K D WS G T + +G P + R+ + Y+ Sbjct: 182 PWVPPECIE-------NPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQ--FYE 232 Query: 237 IITGKPSGAISGVQKAENGPIDWSGD-MPVSCSLSRGLQVLLTPVLA 282 P+ + + N +D+ D P ++ R L L TP L Sbjct: 233 DRHQLPAPKAAELANLINNCMDYEPDHRPSFRAIIRDLNSLFTPDLV 279 >3A4O-X nrPDB Length = 286 Score = 52.0 bits (123), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 55/232 (23%), Positives = 100/232 (43%), Gaps = 31/232 (13%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 74 LG G V+ G + + + A+K + V + E ++K L H +V+L+A+ Sbjct: 21 LGAGQFGEVWMGYYNNSTKV-AVKTLKPGTM--SVQAFLEEANLMKTLQHDKLVRLYAV- 76 Query: 75 EETTTRHK--VLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIV 132 TR + +I E+ GSL L+ L + + + GM ++ + Sbjct: 77 ---VTREEPIYIITEYMAKGSLLDFLKSDEGGKVL-LPKLIDFSAQIAEGMAYIERKNYI 132 Query: 133 HRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTE---EYLHPDMYERAV 189 HRD++ N++ + E + K+ DFG AR +ED+E + + G + ++ P+ Sbjct: 133 HRDLRAANVL--VSE--SLMCKIADFGLARVIEDNE-YTAREGAKFPIKWTAPEAINFGC 187 Query: 190 LRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVMYKIITG 240 + D+WS G+ Y T G +P+ R N +VM + G Sbjct: 188 --------FTIKSDVWSFGILLYEIVTYGKIPY----PGRTNADVMTALSQG 227 >5HVK-A nrPDB Length = 315 Score = 52.0 bits (123), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 47/210 (22%), Positives = 95/210 (45%), Gaps = 22/210 (10%) Query: 12 SDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVD-VQMREFEVLKKLNHKNIVKL 70 ++LG+G + H++TG++ +K I F ++E +V++ L H N++K Sbjct: 19 GEVLGKGCFGQAIKVTHRETGEVMVMKEL--IRFDEETQRTFLKEVKVMRCLEHPNVLKF 76 Query: 71 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 130 + + + I E+ G+L +++ + Y P S+ + +D+ GM +L Sbjct: 77 IGVLYKDKRLN--FITEYIKGGTLRGIIKSMDSQY--PWSQRVSFAKDIASGMAYLHSMN 132 Query: 131 IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVL 190 I+HR++ N + + E+ V + DFG AR + D++ G PD +R + Sbjct: 133 IIHRNLNSHNCL--VRENKNVV--VADFGLARLMVDEK--TQPEGLRSLKKPDRKKRYTV 186 Query: 191 RKD---------HQKKYGATVDLWSIGVTF 211 + + + Y VD++S G+ Sbjct: 187 VGNPYWMAPEMINGRSYDEKVDVFSFGIVL 216 >3NIE-A nrPDB Length = 429 Score = 52.0 bits (123), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 55/228 (24%), Positives = 95/228 (41%), Gaps = 45/228 (19%) Query: 14 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHKNIVKL- 70 ++G+G+ V+ K AIK N + F +D + +RE +L +L I++L Sbjct: 35 LIGRGSYGYVYLAYDKNANKNVAIKKVNRM-FEDLIDCKRILREITILNRLKSDYIIRLH 93 Query: 71 -FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN 129 I E+ ++ I+ L + + P L E +L +++ G + E+ Sbjct: 94 DLIIPEDLLKFDELYIVLEIADSDLKKLFKTP---IFLTEQHVKTILYNLLLGEKFIHES 150 Query: 130 GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD---------------------- 167 GI+HRD+KP N + + +D K+ DFG AR + D Sbjct: 151 GIIHRDLKPANCL--LNQDCS--VKICDFGLARTINSDKDIHIVNDLEEKEENEEPGPHN 206 Query: 168 ----EQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTF 211 +Q S T Y P++ +L Q+ Y ++D+WS G F Sbjct: 207 KNLKKQLTSHVVTRWYRAPEL----ILL---QENYTNSIDIWSTGCIF 247 >2XYN-A nrPDB Length = 292 Score = 51.6 bits (122), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 51/212 (24%), Positives = 90/212 (42%), Gaps = 17/212 (8%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 74 LG G V+ G KK A+K + V+ ++E V+K++ H N+V+L + Sbjct: 40 LGGGQYGEVYVGVWKKYSLTVAVKTLKEDTM--EVEEFLKEAAVMKEIKHPNLVQLLGV- 96 Query: 75 EETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHR 134 T ++ E+ P G+L L E N + L + + M +L + +HR Sbjct: 97 -CTLEPPFYIVTEYMPYGNLLDYLRE-CNREEVTAVVLLYMATQISSAMEYLEKKNFIHR 154 Query: 135 DIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDH 194 D+ N + +GE+ V K+ DFG +R + D + + G + + E Sbjct: 155 DLAARNCL--VGEN--HVVKVADFGLSRLMTGD-TYTAHAGAKFPIKWTAPESLAYN--- 206 Query: 195 QKKYGATVDLWSIGVTFYHAATGSLPFRPFEG 226 + D+W+ GV + AT + P+ G Sbjct: 207 --TFSIKSDVWAFGVLLWEIATYGM--SPYPG 234 >5TE0-A nrPDB Length = 347 Score = 51.6 bits (122), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 56/227 (24%), Positives = 94/227 (41%), Gaps = 28/227 (12%) Query: 11 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLN-HKNIVK 69 + ++L +G A VF R ++F N + V RE ++++ L+ HKNIV Sbjct: 23 VDEVLAEGGFAIVFLVRTSNGMKCALKRMFVNNE--HDLQVCKREIQIMRDLSGHKNIVG 80 Query: 70 LFAIEEETTTRHKV----LIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 125 + V ++M+FC G + ++ + G E+E L + D + Sbjct: 81 YIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQT-GFTENEVLQIFCDTCEAVAR 139 Query: 126 LRE--NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQF---------VSLY 174 L + I+HRD+K NI+ + + G Y L DFG+A + Q + Y Sbjct: 140 LHQCKTPIIHRDLKVENIL--LHDRGH--YVLCDFGSATNKFQNPQTEGVNAVEDEIKKY 195 Query: 175 GTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 T Y P+M + K D+W++G Y +LPF Sbjct: 196 TTLSYRAPEM-----VNLYSGKIITTKADIWALGCLLYKLCYFTLPF 237 >3PP0-A nrPDB Length = 338 Score = 51.6 bits (122), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 55/213 (25%), Positives = 94/213 (44%), Gaps = 19/213 (8%) Query: 14 ILGQGATANVFRGRHKKTGD----LFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVK 69 +LG GA V++G G+ AIKV + + + E V+ + + + Sbjct: 24 VLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSR 83 Query: 70 LFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN 129 L I +T + L+ + P G L + E N L + L + GM++L + Sbjct: 84 LLGICLTSTVQ---LVTQLMPYGCLLDHVRE--NRGRLGSQDLLNWCMQIAKGMSYLEDV 138 Query: 130 GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAV 189 +VHRD+ N++ + K+TDFG AR L+ DE G + + M ++ Sbjct: 139 RLVHRDLAARNVL----VKSPNHVKITDFGLARLLDIDETEYHADGGKVPIK-WMALESI 193 Query: 190 LRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPF 221 LR +++ D+WS GVT + T G+ P+ Sbjct: 194 LR----RRFTHQSDVWSYGVTVWELMTFGAKPY 222 >3G2F-A nrPDB Length = 336 Score = 51.2 bits (121), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 56/229 (24%), Positives = 103/229 (44%), Gaps = 46/229 (20%) Query: 11 LSDILGQGATANVFRGRHKKTGDLFAIKVF---NNISFLRPVDVQMREFEVLKKLNHKNI 67 L +++G+G V++G + A+KVF N +F+ ++ + + H NI Sbjct: 17 LLELIGRGRYGAVYKGSLDERP--VAVKVFSFANRQNFINEKNIYR-----VPLMEHDNI 69 Query: 68 VKLFAIEEETTTRHK---VLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLR---DVVG 121 + +E T + +L+ME+ P GSL L L S+++ R V Sbjct: 70 ARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYL-------SLHTSDWVSSCRLAHSVTR 122 Query: 122 GMNHLR---------ENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAAREL-------- 164 G+ +L + I HRD+ N++ + DG V ++DFG + L Sbjct: 123 GLAYLHTELPRGDHYKPAISHRDLNSRNVL--VKNDGTCV--ISDFGLSMRLTGNRLVRP 178 Query: 165 -EDDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFY 212 E+D +S GT Y+ P++ E AV +D + VD++++G+ ++ Sbjct: 179 GEEDNAAISEVGTIRYMAPEVLEGAVNLRDCESAL-KQVDMYALGLIYW 226 >3BEA-A nrPDB Length = 333 Score = 50.8 bits (120), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 60/244 (24%), Positives = 97/244 (39%), Gaps = 37/244 (15%) Query: 15 LGQGATANVFR----GRHKKTGDL-FAIKVFNNISFLRPVDVQMREFEVLKKLN-HKNIV 68 LG GA V G K+ L A+K+ + + + M E +++ L H+NIV Sbjct: 54 LGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIV 113 Query: 69 KLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSN------AYGLPES-----EFLIVLR 117 L T ++I E+C G L L S A+ + S + L Sbjct: 114 NLLG--ACTHGGPVLVITEYCCYGDLLNFLRRKSRVLETDPAFAIANSTLSTRDLLHFSS 171 Query: 118 DVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTE 177 V GM L +HRD+ N++ G V K+ DFG AR++ +D ++ Sbjct: 172 QVAQGMAFLASKNCIHRDVAARNVLLTNGH----VAKIGDFGLARDIMNDSNYIVKGNAR 227 Query: 178 ---EYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVM 234 +++ P+ V Y D+WS G+ + SL P+ G N + Sbjct: 228 LPVKWMAPESIFDCV--------YTVQSDVWSYGILLWE--IFSLGLNPYPGILVNSK-F 276 Query: 235 YKII 238 YK++ Sbjct: 277 YKLV 280 >5HLW-A nrPDB Length = 299 Score = 50.8 bits (120), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 51/217 (23%), Positives = 91/217 (41%), Gaps = 15/217 (6%) Query: 11 LSDILGQGATANVFRGR---HKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNI 67 ++++G+G V+ G + A+K N I+ + V + E ++K +H N+ Sbjct: 24 FNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNV 83 Query: 68 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLR-DVVGGMNHL 126 + L I + ++++ + G L + ++ P + LI V GM +L Sbjct: 84 LSLLGICLRSEGS-PLVVLPYMKHGDLRNFIRNETHN---PTVKDLIGFGLQVAKGMKYL 139 Query: 127 RENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYE 186 VHRD+ N M D + K+ DFG AR++ D E + S++ P + Sbjct: 140 ASKKFVHRDLAARNCML----DEKFTVKVADFGLARDMHDKEYY-SVHNKTGAKLPVKW- 193 Query: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRP 223 L +K+ D+WS GV + T P P Sbjct: 194 -MALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYP 229 >5NGU-A nrPDB Length = 381 Score = 50.8 bits (120), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 48/196 (24%), Positives = 80/196 (40%), Gaps = 13/196 (6%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 74 +G+GA V AIK + +RE ++L + H+NI+ + I Sbjct: 50 IGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDII 109 Query: 75 EETTTRH--KVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIV 132 T V I++ LY +L+ L L ++ G+ ++ ++ Sbjct: 110 RAPTIEQMKDVYIVQDLMETDLYKLLK----TQHLSNDHICYFLYQILRGLKYIHSANVL 165 Query: 133 HRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRK 192 HRD+KP N++ D K+ DFG AR + D EY+ Y RA Sbjct: 166 HRDLKPSNLLLNTTCD----LKICDFGLARVADPDHDHTGF--LTEYVATRWY-RAPEIM 218 Query: 193 DHQKKYGATVDLWSIG 208 + K Y ++D+WS+G Sbjct: 219 LNSKGYTKSIDIWSVG 234 >3G0E-A nrPDB Length = 336 Score = 50.4 bits (119), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 50/206 (24%), Positives = 83/206 (40%), Gaps = 34/206 (16%) Query: 36 AIKVFNNISFLRPVDVQMREFEVLKKL-NHKNIVKLFAIEEETTTRHKVLIMEFCPCGSL 94 A+K+ + L + M E +VL L NH NIV L T ++I E+C G L Sbjct: 80 AVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLG--ACTIGGPTLVITEYCCYGDL 137 Query: 95 YTVLEEPSNAYGLPESEFLIVLR---------------DVVGGMNHLRENGIVHRDIKPG 139 L +++ ++ I+ V GM L +HRD+ Sbjct: 138 LNFLRRKRDSFICSKTSPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAAR 197 Query: 140 NIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTE---EYLHPDMYERAVLRKDHQK 196 NI+ G + K+ DFG AR++++D +V +++ P+ V Sbjct: 198 NILLTHGR----ITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCV------- 246 Query: 197 KYGATVDLWSIGVTFYHA-ATGSLPF 221 Y D+WS G+ + + GS P+ Sbjct: 247 -YTFESDVWSYGIFLWELFSLGSSPY 271 >4MWI-A nrPDB Length = 294 Score = 50.4 bits (119), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 56/234 (23%), Positives = 99/234 (42%), Gaps = 38/234 (16%) Query: 5 SNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQM---REFEVLKK 61 S W+L L + + +++G + + AIKVF + V+ +E + +KK Sbjct: 25 SGSPWIL---LRENEVSTLYKGEYHRAP--VAIKVFKKLQAGSIAIVRQTFNKEIKTMKK 79 Query: 62 LNHKNIVKLFAI--EEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDV 119 NI+++F I +E T ++ME+C G+L +L+ + L + ++++ Sbjct: 80 FESPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLDREKD---LTLGKRMVLVLGA 136 Query: 120 VGGMN--HLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTE 177 G+ H E +H I+ N + G KL F EL + +SL T Sbjct: 137 ARGLYRLHHSEAPELHGKIRSSNFLVTQGYQ----VKLAGF----ELRKTQTSMSLGTTR 188 Query: 178 E---------YLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFR 222 E YL P E D +Y +++S G+ + ATG +PF+ Sbjct: 189 EKTDRVKSTAYLSPQELE------DVFYQYDVKSEIYSFGIVLWEIATGDIPFQ 236 >4CRL-A nrPDB Length = 406 Score = 50.4 bits (119), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 43/168 (25%), Positives = 75/168 (44%), Gaps = 18/168 (10%) Query: 54 REFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTV-LEEPSNA----YGLP 108 RE +L++L H N++ L + R L+ ++ + + S A LP Sbjct: 68 REIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLP 127 Query: 109 ESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQ-SVYKLTDFGAAR----E 163 +L ++ G+++L N ++HRD+KP NI+ V+GE + K+ D G AR Sbjct: 128 RGMVKSLLYQILDGIHYLHANWVLHRDLKPANIL-VMGEGPERGRVKIADMGFARLFNSP 186 Query: 164 LEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTF 211 L+ + T Y P++ A + Y +D+W+IG F Sbjct: 187 LKPLADLDPVVVTFWYRAPELLLGA-------RHYTKAIDIWAIGCIF 227 >4LRM-A nrPDB Length = 334 Score = 50.1 bits (118), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 58/219 (26%), Positives = 96/219 (43%), Gaps = 28/219 (12%) Query: 14 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKL---------NH 64 +LG GA V++G G+ +K+ I LR E+L + + Sbjct: 26 VLGSGAFGTVYKGLWIPEGE--KVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGN 83 Query: 65 KNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLI-VLRDVVGGM 123 ++ +L I +T + LI + P G L + E + G S++L+ + GM Sbjct: 84 PHVCRLLGICLTSTVQ---LITQLMPFGCLLDYVREHKDNIG---SQYLLNWCVQIAKGM 137 Query: 124 NHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPD 183 N+L + +VHRD+ N V+ + Q V K+TDFG A+ L +E+ G + + Sbjct: 138 NYLEDRRLVHRDLAARN---VLVKTPQHV-KITDFGLAKLLGAEEKEYHAEGGKVPI--- 190 Query: 184 MYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPF 221 + L + Y D+WS GVT + T GS P+ Sbjct: 191 --KWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPY 227 >4QTB-A nrPDB Length = 380 Score = 50.1 bits (118), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 49/196 (25%), Positives = 86/196 (43%), Gaps = 13/196 (6%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 74 +G+GA V AIK + +RE ++L + H+N++ + I Sbjct: 49 IGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDIL 108 Query: 75 EETT--TRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIV 132 +T V I++ LY +L+ + L L ++ G+ ++ ++ Sbjct: 109 RASTLEAMRDVYIVQDLMETDLYKLLK----SQQLSNDHICYFLYQILRGLKYIHSANVL 164 Query: 133 HRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRK 192 HRD+KP N++ D K+ DFG AR + D E + + T EY+ Y RA Sbjct: 165 HRDLKPSNLLINTTCD----LKICDFGLAR-IADPEHDHTGFLT-EYVATRWY-RAPEIM 217 Query: 193 DHQKKYGATVDLWSIG 208 + K Y ++D+WS+G Sbjct: 218 LNSKGYTKSIDIWSVG 233 >2FO0-A nrPDB Length = 495 Score = 50.1 bits (118), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 52/214 (24%), Positives = 91/214 (42%), Gaps = 21/214 (9%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 74 LG G V+ G KK A+K + V+ ++E V+K++ H N+V+L + Sbjct: 225 LGGGQYGEVYEGVWKKYSLTVAVKTLKEDTM--EVEEFLKEAAVMKEIKHPNLVQLLGV- 281 Query: 75 EETTTRHK--VLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIV 132 TR +I EF G+L L E N + L + + M +L + + Sbjct: 282 ---CTREPPFYIITEFMTYGNLLDYLRE-CNRQEVNAVVLLYMATQISSAMEYLEKKNFI 337 Query: 133 HRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRK 192 HR++ N + +GE+ + K+ DFG +R + D + + G + + E Sbjct: 338 HRNLAARNCL--VGEN--HLVKVADFGLSRLMTGD-TYTAHAGAKFPIKWTAPESLAY-- 390 Query: 193 DHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEG 226 K+ D+W+ GV + AT + P+ G Sbjct: 391 ---NKFSIKSDVWAFGVLLWEIATYGM--SPYPG 419 >6GQK-A nrPDB Length = 328 Score = 50.1 bits (118), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 50/187 (26%), Positives = 77/187 (41%), Gaps = 32/187 (17%) Query: 53 MREFEVLKKL-NHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEE----------- 100 M E +VL L NH+NIV L T ++I E+C G L L Sbjct: 92 MSELKVLSYLGNHENIVNLLG--ACTHGGPTLVITEYCCYGDLLNFLRRKRDEFVPYKVA 149 Query: 101 PSNAYG--LPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDF 158 P + Y L L V GM L +HRD+ NI+ G ++ K+ DF Sbjct: 150 PEDLYKDFLTLEHLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHG----NITKICDF 205 Query: 159 GAARELEDDEQFVSLYGTE---EYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHA- 214 G AR++++D +V +++ P+ +V Y D+WS G+ + Sbjct: 206 GLARDIKNDSNYVDKGNARLPVKWMAPESIFNSV--------YTFESDVWSYGIFLWELF 257 Query: 215 ATGSLPF 221 + GS P+ Sbjct: 258 SLGSSPY 264 >4M66-A nrPDB Length = 325 Score = 50.1 bits (118), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 42/154 (27%), Positives = 73/154 (47%), Gaps = 23/154 (14%) Query: 13 DILGQGATANVFRGRHKKTGDLFAIKVFNN--ISFLRPVDVQMREFEVLKKLNHKNIVKL 70 + +G+G VFR H+ A+K+ N+ IS+ E + + L ++N++ L Sbjct: 26 EFVGKGGFGVVFRAHHRTWNHDVAVKIVNSKKISW---------EVKAMVNLRNENVLLL 76 Query: 71 FAIEEETT---TRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 127 + E+ + L+ F GSL +L+ + P +L++VV GM +L Sbjct: 77 LGVTEDLQWDFVSGQALVTRFMENGSLAGLLQPEAPR---PWPLLCRLLQEVVLGMCYLH 133 Query: 128 --ENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFG 159 + ++HRD+KP NI+ D + KL DFG Sbjct: 134 SLDPPLLHRDLKPSNILL----DPELHAKLADFG 163 >3V5Q-A nrPDB Length = 297 Score = 49.7 bits (117), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 63/251 (25%), Positives = 103/251 (41%), Gaps = 45/251 (17%) Query: 15 LGQGATANVFRGR-----HKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVK 69 LG+GA VF K L A+K + + D Q RE E+L L H++IVK Sbjct: 23 LGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQ-REAELLTNLQHEHIVK 81 Query: 70 LFAIEEETTTRHKVLIMEFCPCGSLYTVLE------------EPSNAYG-LPESEFLIVL 116 + + + +++ E+ G L L +P A G L S+ L + Sbjct: 82 FYGVCGDGDPL--IMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIA 139 Query: 117 RDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGT 176 + GM +L VHRD+ N + +G + + K+ DFG +R++ + + T Sbjct: 140 SQIASGMVYLASQHFVHRDLATRNCL--VGAN--LLVKIGDFGMSRDVYSTDYYRVGGHT 195 Query: 177 E---EYLHPD--MYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRN 230 ++ P+ MY +K+ D+WS GV + T G P+ N Sbjct: 196 MLPIRWMPPESIMY----------RKFTTESDVWSFGVILWEIFTYGKQPWFQLS----N 241 Query: 231 KEVMYKIITGK 241 EV+ I G+ Sbjct: 242 TEVIECITQGR 252 >5U6B-A nrPDB Length = 307 Score = 49.7 bits (117), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 52/233 (22%), Positives = 98/233 (42%), Gaps = 34/233 (14%) Query: 7 HLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFN-NISFLRPVDVQ--MREFEVLKKLN 63 H L LG+G V G+ + + + V I+ +++ + E +K+ + Sbjct: 23 HKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFD 82 Query: 64 HKNIVKLFAIEEETTTRHK----VLIMEFCPCGSLYTVL------EEPSNAYGLPESEFL 113 H N+++L + + + R V+I+ F G L++ L ++P LP + Sbjct: 83 HPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVY---LPTQMLV 139 Query: 114 IVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSL 173 + D+ GM +L +HRD+ N M + SV + DFG +++ + Sbjct: 140 KFMADIASGMEYLSTKRFIHRDLAARNCML---NENMSVC-VADFGLSKK---------I 186 Query: 174 YGTEEYLHPDMYERAV----LRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPF 221 Y + Y + + V + + Y + D+WS GVT + AT G P+ Sbjct: 187 YNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPY 239 >4XLV-A nrPDB Length = 328 Score = 49.3 bits (116), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 60/244 (24%), Positives = 102/244 (41%), Gaps = 38/244 (15%) Query: 15 LGQGATANVFRGRHK-----KTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVK 69 LGQG+ V+ G + + A+K N + LR + E V+K ++V+ Sbjct: 47 LGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVR 106 Query: 70 LFAIEEETTTRHKVLIMEFCPCGSLYTVLE----EPSNAYGLPES---EFLIVLRDVVGG 122 L + + + +++ME G L + L E N G P E + + ++ G Sbjct: 107 LLGVV--SKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADG 164 Query: 123 MNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEY--- 179 M +L VHRD+ N M + D K+ DFG R+ +Y T+ Y Sbjct: 165 MAYLNAKKFVHRDLAARNCM--VAHD--FTVKIGDFGMTRD---------IYETDYYRKG 211 Query: 180 ---LHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYK 236 L P + KD + + D+WS GV + SL +P++G N++V+ Sbjct: 212 GKGLLPVRWMAPESLKD--GVFTTSSDMWSFGVVLWEIT--SLAEQPYQG-LSNEQVLKF 266 Query: 237 IITG 240 ++ G Sbjct: 267 VMDG 270 >2PZI-A nrPDB Length = 681 Score = 49.3 bits (116), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 51/175 (29%), Positives = 82/175 (46%), Gaps = 34/175 (19%) Query: 54 REFEVLKKLNHKNIVKLFAIEEETTTRHK----VLIMEFCPCGSLYTVLEEPSNAYGLPE 109 R+F L ++ H +IV++F E T RH ++ME+ SL + S LP Sbjct: 130 RQF--LAEVVHPSIVQIFNFVEHTD-RHGDPVGYIVMEYVGGQSL-----KRSKGQKLPV 181 Query: 110 SEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQ 169 +E + L +++ +++L G+V+ D+KP NIM + KL D GA + Sbjct: 182 AEAIAYLLEILPALSYLHSIGLVYNDLKPENIMLT-----EEQLKLIDLGAVSRI---NS 233 Query: 170 FVSLYGTEEYLHPDMYERAVLRKDHQKKYGATV--DLWSIGVTFYHAATGSLPFR 222 F LYGT + P++ + G TV D++++G T A T LP R Sbjct: 234 FGYLYGTPGFQAPEIV-----------RTGPTVATDIYTVGRTL-AALTLDLPTR 276 >3C1X-A nrPDB Length = 373 Score = 49.3 bits (116), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 54/219 (24%), Positives = 91/219 (41%), Gaps = 19/219 (8%) Query: 11 LSDILGQGATANVFRGR-----HKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHK 65 ++++G+G V+ G KK A+K N I+ + V + E ++K +H Sbjct: 93 FNEVIGRGHFGCVYHGTLLDNDGKKIH--CAVKSLNRITDIGEVSQFLTEGIIMKDFSHP 150 Query: 66 NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLR-DVVGGMN 124 N++ L I + ++++ + G L + ++ P + LI V GM Sbjct: 151 NVLSLLGICLRSEGS-PLVVLPYMKHGDLRNFIRNETHN---PTVKDLIGFGLQVAKGMK 206 Query: 125 HLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDM 184 L VHRD+ N M D + K+ DFG AR++ D E F S++ P Sbjct: 207 FLASKKFVHRDLAARNCML----DEKFTVKVADFGLARDMYDKE-FDSVHNKTGAKLPVK 261 Query: 185 YERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRP 223 + L +K+ D+WS GV + T P P Sbjct: 262 W--MALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYP 298 >3CJF-A nrPDB Length = 309 Score = 48.9 bits (115), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 61/241 (25%), Positives = 99/241 (41%), Gaps = 32/241 (13%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHK-NIVKLFAI 73 GQ A+ F T A+K+ + M E ++L + H N+V L Sbjct: 40 FGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGA 99 Query: 74 EEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPES---------EFLIVLR-DVVGGM 123 + V I+EFC G+L T L N + +P E LI V GM Sbjct: 100 CTKPGGPLMV-IVEFCKFGNLSTYLRSKRNEF-VPYKDLYKDFLTLEHLICYSFQVAKGM 157 Query: 124 NHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTE---EYL 180 L +HRD+ NI+ + E ++V K+ DFG AR++ D +V +++ Sbjct: 158 EFLASRKCIHRDLAARNIL--LSE--KNVVKICDFGLARDIYKDPDYVRKGDARLPLKWM 213 Query: 181 HPD-MYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIIT 239 P+ +++R Y D+WS GV + SL P+ G + ++E ++ Sbjct: 214 APETIFDRV---------YTIQSDVWSFGVLLWEIF--SLGASPYPGVKIDEEFCRRLKE 262 Query: 240 G 240 G Sbjct: 263 G 263 >4O2Z-A nrPDB Length = 377 Score = 48.9 bits (115), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 58/249 (23%), Positives = 103/249 (41%), Gaps = 32/249 (12%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIK----VFNNISFLRPVDVQMREFEVLKKLNH 64 + L ILG GA TG+ +IK VF ++ + V +RE ++++ +H Sbjct: 47 YTLLKILGMGAYGIACSCLDGDTGEKVSIKKCRDVFRDVEDGKRV---LREIDMMRFFHH 103 Query: 65 KNIVKLFAI----EEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVV 120 +N++ + I + E + V ++ + VL + L ES + ++ Sbjct: 104 ENLLNVVNILPPLKREYHSFEDVYVVTPLMDVDMNVVLR---SRQVLEESHMQYFVYQIL 160 Query: 121 GGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYL 180 G+ +L + HRD+KP N++ I + K+ DFG +R ++ ++ Y + Sbjct: 161 RGLKYLHSANVAHRDLKPANLVTNISCE----LKIIDFGLSRSVDVPYSELTDYVITRWY 216 Query: 181 HPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIIT- 239 P +L Y VD+WS+G F F P RN ++I Sbjct: 217 RP---PELLLE---NTNYSTAVDIWSVGCIFAEMYNRKPVF-----PGRNTMDQLRMIAQ 265 Query: 240 --GKPSGAI 246 GKP +I Sbjct: 266 HIGKPPASI 274 >4HZS-A nrPDB Length = 341 Score = 48.5 bits (114), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 54/230 (23%), Positives = 92/230 (40%), Gaps = 25/230 (10%) Query: 15 LGQGATANVFRGRHKKTGD---LFAIKVFNNISFLRP--VDVQMREFEVLKKLNHKNIVK 69 LG G+ V RG A+K +P +D +RE + L+H+N+++ Sbjct: 20 LGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNLIR 79 Query: 70 LFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN 129 L+ + T ++ E P GSL L + + L V V GM +L Sbjct: 80 LYGV---VLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAV--QVAEGMGYLESK 134 Query: 130 GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAAREL-EDDEQFVSLYGTEEYLHPDMYERA 188 +HRD+ N++ + + K+ DFG R L ++D+ +V E P + Sbjct: 135 RFIHRDLAARNLLLAT----RDLVKIGDFGLMRALPQNDDHYVM---QEHRKVP--FAWC 185 Query: 189 VLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVMYKI 237 + + D W GVT + T G P+ G ++++KI Sbjct: 186 APESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNG----SQILHKI 231 >1U54-B nrPDB Length = 291 Score = 48.5 bits (114), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 54/230 (23%), Positives = 92/230 (40%), Gaps = 25/230 (10%) Query: 15 LGQGATANVFRGRHKKTGD---LFAIKVFNNISFLRP--VDVQMREFEVLKKLNHKNIVK 69 LG G+ V RG A+K +P +D +RE + L+H+N+++ Sbjct: 26 LGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNLIR 85 Query: 70 LFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN 129 L+ + T ++ E P GSL L + + L V V GM +L Sbjct: 86 LYGV---VLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAV--QVAEGMGYLESK 140 Query: 130 GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAAREL-EDDEQFVSLYGTEEYLHPDMYERA 188 +HRD+ N++ + + K+ DFG R L ++D+ +V E P + Sbjct: 141 RFIHRDLAARNLLLAT----RDLVKIGDFGLMRALPQNDDHYVM---QEHRKVP--FAWC 191 Query: 189 VLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVMYKI 237 + + D W GVT + T G P+ G ++++KI Sbjct: 192 APESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNG----SQILHKI 237 >3PG1-A nrPDB Length = 362 Score = 48.5 bits (114), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 45/182 (24%), Positives = 75/182 (41%), Gaps = 24/182 (13%) Query: 38 KVFNNISFLRPVDV---------QMREFEVLKKLNHKNIVKL--FAIEEETTTRHKVLIM 86 +VFN +S R V++ +RE +L +H NI+ L + E HK+ ++ Sbjct: 53 RVFNTVSDGRTVNILSDSFLCKRVLREIRLLNHFHHPNILGLRDIFVHFEEPAMHKLYLV 112 Query: 87 EFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIG 146 L V+ + ++ + ++ G++ L E G+VHRD+ PGNI+ Sbjct: 113 TELMRTDLAQVIHDQRIVISPQHIQYF--MYHILLGLHVLHEAGVVHRDLHPGNILLADN 170 Query: 147 EDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWS 206 D + DF ARE D Y P++ + K + VD+WS Sbjct: 171 ND----ITICDFNLAREDTADANKTHYVTHRWYRAPELVMQF-------KGFTKLVDMWS 219 Query: 207 IG 208 G Sbjct: 220 AG 221 >5L2Q-C nrPDB Length = 320 Score = 48.1 bits (113), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 38/135 (28%), Positives = 61/135 (45%), Gaps = 14/135 (10%) Query: 107 LPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELED 166 L E E +++ DVV + L + IVHRD+K GN+ V+ + + +T+F + L Sbjct: 150 LSERETVVIFYDVVRVVEALHQKNIVHRDLKLGNM--VLNKRTHRI-TITNFCLGKHLVS 206 Query: 167 DEQFV-SLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFR--- 222 + + G+ Y+ PD+ R G D+W++GV + G PF Sbjct: 207 EGDLLKDQRGSPAYISPDVLSGRPYR-------GKPSDMWALGVVLFTMLYGQFPFYDSI 259 Query: 223 PFEGPRRNKEVMYKI 237 P E R+ K Y I Sbjct: 260 PQELFRKIKAAEYTI 274 >4R7H-A nrPDB Length = 343 Score = 48.1 bits (113), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 63/254 (24%), Positives = 100/254 (39%), Gaps = 48/254 (18%) Query: 15 LGQGATANVFR----GRHKKTGDL-FAIKVFNNISFLRPVDVQMREFEVLKKLN-HKNIV 68 LG GA V G K+ L A+K+ + + + M E +++ L H+NIV Sbjct: 58 LGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIV 117 Query: 69 KLFAIEEETTTRHKVLIM-EFCPCGSLYTVLEEPSNAYGLP-------------ESEFLI 114 L T VL++ E+C G L L + A P E + Sbjct: 118 NLLG---ACTHGGPVLVITEYCTYGDLLNFLRRKAEAMLGPSLSPGQDPEGLDKEDGRPL 174 Query: 115 VLRD-------VVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD 167 LRD V GM L +HRD+ N++ G V K+ DFG AR++ +D Sbjct: 175 ELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGH----VAKIGDFGLARDIMND 230 Query: 168 EQFVSLYGTE---EYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPF 224 ++ +++ P+ +V Y D+WS G+ + SL P+ Sbjct: 231 SNYIVKGNARLPVKWMAPESIFDSV--------YTVQSDVWSYGILLWEIF--SLGLNPY 280 Query: 225 EGPRRNKEVMYKII 238 G N + YK++ Sbjct: 281 PGILVNSK-FYKLV 293 >5WNO-A nrPDB Length = 330 Score = 48.1 bits (113), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 51/219 (23%), Positives = 95/219 (43%), Gaps = 31/219 (14%) Query: 15 LGQGATANVFRG-----RHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVK 69 LG GA VF G R K AIKVF D + E + +L H N++K Sbjct: 30 LGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTDQ--SQTDEMLEEATNMFRLRHDNLLK 87 Query: 70 L--FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 127 + F + ++ ++ + P G+L L+ G E ++ + GM +L Sbjct: 88 IIGFCMHDDGLK----IVTIYRPLGNLQNFLKLHKENLGAREQ--VLYCYQIASGMQYLE 141 Query: 128 ENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTE---EYLHPDM 184 + +VHRD+ N++ + ++TDFG ++ L+ D +++ + ++L ++ Sbjct: 142 KQRVVHRDLATRNVL----VKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIEI 197 Query: 185 YERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFR 222 + + Y D+W+ GVT + T G P++ Sbjct: 198 FSKHC--------YTHASDVWAFGVTCWEIITFGQSPYQ 228 >5GRN-A nrPDB Length = 356 Score = 48.1 bits (113), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 65/277 (23%), Positives = 104/277 (37%), Gaps = 54/277 (19%) Query: 10 LLSDILGQGATANVFRG------RHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLN 63 +L +LG GA V G R + + A+K+ + M E +++ L Sbjct: 49 VLGRVLGSGAFGKVVEGTAYGLSRSQPVMKV-AVKMLKPTARSSEKQALMSELKIMTHLG 107 Query: 64 -HKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAY----------------- 105 H NIV L ++ + +I E+C G L L + +++ Sbjct: 108 PHLNIVNLLGACTKSGPIY--IITEYCFYGDLVNYLHKNRDSFLSHKKKSMLDSEVKNLL 165 Query: 106 ------GLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFG 159 GL + L V GM L VHRD+ N++ G+ + K+ DFG Sbjct: 166 SDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGK----IVKICDFG 221 Query: 160 AARELEDDEQFVSLYGT---EEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT 216 AR++ D +VS T +++ P+ Y D+WS G+ + Sbjct: 222 LARDIMHDSNYVSKGSTFLPVKWMAPE--------SIFDNLYTTLSDVWSYGILLWEIF- 272 Query: 217 GSLPFRPFEGPRRNKEVMYKIITG----KPSGAISGV 249 SL P+ G + KI +G KP A S V Sbjct: 273 -SLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEV 308 >4Y12-A nrPDB Length = 375 Score = 48.1 bits (113), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 51/175 (29%), Positives = 82/175 (46%), Gaps = 34/175 (19%) Query: 54 REFEVLKKLNHKNIVKLFAIEEETTTRHK----VLIMEFCPCGSLYTVLEEPSNAYGLPE 109 R+F L ++ H +IV++F E T RH ++ME+ SL + S LP Sbjct: 169 RQF--LAEVVHPSIVQIFNFVEHTD-RHGDPVGYIVMEYVGGQSL-----KRSKGQKLPV 220 Query: 110 SEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQ 169 +E + L +++ +++L G+V+ D+KP NIM + KL D GA + Sbjct: 221 AEAIAYLLEILPALSYLHSIGLVYNDLKPENIMLT-----EEQLKLIDLGAVSRI---NS 272 Query: 170 FVSLYGTEEYLHPDMYERAVLRKDHQKKYGATV--DLWSIGVTFYHAATGSLPFR 222 F LYGT + P++ + G TV D++++G T A T LP R Sbjct: 273 FGYLYGTPGFQAPEIV-----------RTGPTVATDIYTVGRTL-AALTLDLPTR 315 >3KRL-A nrPDB Length = 335 Score = 48.1 bits (113), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 61/247 (24%), Positives = 96/247 (38%), Gaps = 41/247 (16%) Query: 15 LGQGATANVFR----GRHKKTGDL-FAIKVFNNISFLRPVDVQMREFEVLKKLN-HKNIV 68 LG GA V G K+ L A+K+ + + + M E +++ L H+NIV Sbjct: 54 LGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIV 113 Query: 69 KLFAIEEETTTRHKVLIM-EFCPCGSLYTVLEE---PSNAYG----------LPESEFLI 114 L T VL++ E+C G L L P Y L + L Sbjct: 114 NLLG---ACTHGGPVLVITEYCCYGDLLNFLRRKRPPGLEYSYNPSHNPEEQLSSRDLLH 170 Query: 115 VLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLY 174 V GM L +HRD+ N++ G V K+ DFG AR++ +D ++ Sbjct: 171 FSSQVAQGMAFLASKNCIHRDVAARNVLLTNGH----VAKIGDFGLARDIMNDSNYIVKG 226 Query: 175 GTE---EYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNK 231 +++ P+ V Y D+WS G+ + SL P+ G N Sbjct: 227 NARLPVKWMAPESIFDCV--------YTVQSDVWSYGILLWEIF--SLGLNPYPGILVNS 276 Query: 232 EVMYKII 238 + YK++ Sbjct: 277 K-FYKLV 282 >5KMM-A nrPDB Length = 329 Score = 47.8 bits (112), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 66/259 (25%), Positives = 101/259 (38%), Gaps = 45/259 (17%) Query: 15 LGQGATANVFRGR-----HKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVK 69 LG+GA VF ++ L A+K S D Q RE E+L L H++IV+ Sbjct: 43 LGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQ-REAELLTMLQHQHIVR 101 Query: 70 LFAIEEETTTRHKVLIMEFCPCGSLYTVLE------------EPSNAYGLPESEFLIVLR 117 F + T R +++ E+ G L L E L + L V Sbjct: 102 FFGVC--TEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVAS 159 Query: 118 DVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTE 177 V GM +L VHRD+ N + +G+ V K+ DFG +R++ + + + G Sbjct: 160 QVAAGMVYLAGLHFVHRDLATRNCL--VGQG--LVVKIGDFGMSRDIYSTD-YYRVGGRT 214 Query: 178 EYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPF--------------- 221 M ++L +K+ D+WS GV + T G P+ Sbjct: 215 MLPIRWMPPESIL----YRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQG 270 Query: 222 RPFEGPRRNKEVMYKIITG 240 R E PR +Y I+ G Sbjct: 271 RELERPRACPPEVYAIMRG 289 >4NEU-A nrPDB Length = 333 Score = 47.8 bits (112), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 41/155 (26%), Positives = 72/155 (46%), Gaps = 13/155 (8%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIV 68 +L S L G V H+ G + V+ + + + + E +++ +L H +V Sbjct: 26 FLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVV 85 Query: 69 KLFA--IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 126 KL IEE + L+ME+ G+L VL+ + P S ++ +++ GM +L Sbjct: 86 KLLGVIIEEGKYS----LVMEYMEKGNLMHVLKAEMST---PLSVKGRIILEIIEGMCYL 138 Query: 127 RENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAA 161 G++H+D+KP NI+ D K+ D G A Sbjct: 139 HGKGVIHKDLKPENILV----DNDFHIKIADLGLA 169 >4XUF-A nrPDB Length = 297 Score = 47.8 bits (112), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 63/242 (26%), Positives = 93/242 (38%), Gaps = 45/242 (18%) Query: 14 ILGQGATANVFRGRH---KKTGDLF--AIKVFNNISFLRPVDVQMREFEVLKKL-NHKNI 67 +LG GA V KTG A+K+ + + M E +++ +L +H+NI Sbjct: 16 VLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENI 75 Query: 68 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLE-----------EPSNAYGLPESEFLIVL 116 V L T + LI E+C G L L E N L E E L VL Sbjct: 76 VNLLG--ACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRLEEEEDLNVL 133 Query: 117 R---------DVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD 167 V GM L VHRD+ N++ G+ V K+ DFG AR++ D Sbjct: 134 TFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGK----VVKICDFGLARDIMSD 189 Query: 168 EQFVSLYGTE---EYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPF 224 +V +++ P+ + Y D+WS G+ + SL P+ Sbjct: 190 SNYVVRGNARLPVKWMAPESLFEGI--------YTIKSDVWSYGILLWEIF--SLGVNPY 239 Query: 225 EG 226 G Sbjct: 240 PG 241 >4BTF-A nrPDB Length = 469 Score = 47.8 bits (112), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 52/215 (24%), Positives = 91/215 (42%), Gaps = 21/215 (9%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMR---EFEVLKKLNHKNIVKLF 71 L + ++RG + ++ IKVFNN V+ E + +KK + NI+++F Sbjct: 203 LKTSKMSTIYRGEYHRSP--VTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIF 260 Query: 72 AIEEETTTRHK--VLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN 129 I + T + ++ME+C G+L +L+ + S L+VLR G+ L + Sbjct: 261 GICIDQTVKPPEFSIVMEYCELGTLRELLDREKDLTMSVRS--LLVLR-AARGLYRLHHS 317 Query: 130 GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTE---EYLHPDMYE 186 +HR+I + + G KL F EL + +S E +Y Sbjct: 318 ETLHRNISSSSFLVA----GGYQVKLAGF----ELSKTQNSISRTAKSTKAERSSSTIYV 369 Query: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 K+ Y +++S G+ + ATG +PF Sbjct: 370 SPERLKNPFCLYDIKAEIYSFGIVLWEIATGKIPF 404 >5X02-A nrPDB Length = 347 Score = 47.8 bits (112), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 63/242 (26%), Positives = 93/242 (38%), Gaps = 45/242 (18%) Query: 14 ILGQGATANVFRGRH---KKTGDLF--AIKVFNNISFLRPVDVQMREFEVLKKL-NHKNI 67 +LG GA V KTG A+K+ + + M E +++ +L +H+NI Sbjct: 55 VLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENI 114 Query: 68 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLE-----------EPSNAYGLPESEFLIVL 116 V L T + LI E+C G L L E N L E E L VL Sbjct: 115 VNLLGAC--TLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRLEEEEDLNVL 172 Query: 117 R---------DVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD 167 V GM L VHRD+ N++ G+ V K+ DFG AR++ D Sbjct: 173 TFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGK----VVKICDFGLARDIMSD 228 Query: 168 EQFVSLYGTE---EYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPF 224 +V +++ P+ + Y D+WS G+ + SL P+ Sbjct: 229 SNYVVRGNARLPVKWMAPESLFEGI--------YTIKSDVWSYGILLWEIF--SLGVNPY 278 Query: 225 EG 226 G Sbjct: 279 PG 280 >5TUR-A nrPDB Length = 404 Score = 47.4 bits (111), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 29/103 (28%), Positives = 48/103 (46%), Gaps = 11/103 (10%) Query: 119 VVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEE 178 V+ + H G++HRDIK NI+ + + KL DFG+ L+D + GT Sbjct: 242 VLEAVRHCHNCGVLHRDIKDENILIDLN---RGELKLIDFGSGALLKD-TVYTDFDGTRV 297 Query: 179 YLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 Y P+ + + +G + +WS+G+ Y G +PF Sbjct: 298 YSPPEWIR-------YHRYHGRSAAVWSLGILLYDMVCGDIPF 333 >3BGP-A nrPDB Length = 333 Score = 47.4 bits (111), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 29/103 (28%), Positives = 48/103 (46%), Gaps = 11/103 (10%) Query: 119 VVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEE 178 V+ + H G++HRDIK NI+ + + KL DFG+ L+D + GT Sbjct: 171 VLEAVRHCHNCGVLHRDIKDENILIDLN---RGELKLIDFGSGALLKD-TVYTDFDGTRV 226 Query: 179 YLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 Y P+ + + +G + +WS+G+ Y G +PF Sbjct: 227 YSPPEWIR-------YHRYHGRSAAVWSLGILLYDMVCGDIPF 262 >4M69-B nrPDB Length = 283 Score = 47.4 bits (111), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 52/215 (24%), Positives = 91/215 (42%), Gaps = 21/215 (9%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMR---EFEVLKKLNHKNIVKLF 71 L + ++RG + ++ IKVFNN V+ E + +KK + NI+++F Sbjct: 17 LKTSKMSTIYRGEYHRSP--VTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIF 74 Query: 72 AIEEETTTRHK--VLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN 129 I + T + ++ME+C G+L +L+ + S L+VLR G+ L + Sbjct: 75 GICIDQTVKPPEFSIVMEYCELGTLRELLDREKDLTMSVRS--LLVLR-AARGLYRLHHS 131 Query: 130 GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTE---EYLHPDMYE 186 +HR+I + + G KL F EL + +S E +Y Sbjct: 132 ETLHRNISSSSFLVA----GGYQVKLAGF----ELSKTQNSISRTAKSTKAERSSSTIYV 183 Query: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 K+ Y +++S G+ + ATG +PF Sbjct: 184 SPERLKNPFCLYDIKAEIYSFGIVLWEIATGKIPF 218 >4RC3-A nrPDB Length = 289 Score = 47.4 bits (111), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 29/103 (28%), Positives = 48/103 (46%), Gaps = 11/103 (10%) Query: 119 VVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEE 178 V+ + H G++HRDIK NI+ + + KL DFG+ L+D + GT Sbjct: 127 VLEAVRHCHNCGVLHRDIKDENILIDLN---RGELKLIDFGSGALLKD-TVYTDFDGTRV 182 Query: 179 YLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 Y P+ + + +G + +WS+G+ Y G +PF Sbjct: 183 YSPPEWIR-------YHRYHGRSAAVWSLGILLYDMVCGDIPF 218 >2JD5-A nrPDB Length = 373 Score = 47.4 bits (111), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 39/152 (25%), Positives = 67/152 (44%), Gaps = 13/152 (8%) Query: 84 LIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL-RENGIVHRDIKPGNIM 142 ++M F G L + G+P + + ++ G++++ R GI+H DIKP N++ Sbjct: 105 VVMVFEVLGENLLALIKKYEHRGIPLIYVKQISKQLLLGLDYMHRRCGIIHTDIKPENVL 164 Query: 143 RVIGEDGQSVY--KLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGA 200 I + +++ K+ D G A DE + + T EY P++ A +G Sbjct: 165 MEIVDSPENLIQIKIADLGNACWY--DEHYTNSIQTREYRSPEVLLGA--------PWGC 214 Query: 201 TVDLWSIGVTFYHAATGSLPFRPFEGPRRNKE 232 D+WS + TG F P EG K+ Sbjct: 215 GADIWSTACLIFELITGDFLFEPDEGHSYTKD 246 >5UNP-A nrPDB Length = 369 Score = 47.0 bits (110), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 63/271 (23%), Positives = 115/271 (42%), Gaps = 44/271 (16%) Query: 15 LGQGATANVFRG-RHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKN------I 67 LG+G V + H++ G A+K+ N+ + + E VL+K+N K+ Sbjct: 42 LGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYK--EAARLEINVLEKINEKDPDNKNLC 99 Query: 68 VKLFAIEEETTTRHKVLIMEFCPCG-SLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 126 V++F + H + + F G S + L++ +N P + + + + L Sbjct: 100 VQMF----DWFDYHGHMCISFELLGLSTFDFLKD-NNYLPYPIHQVRHMAFQLCQAVKFL 154 Query: 127 RENGIVHRDIKPGNIMRVIGE-----------DGQSV----YKLTDFGAARELEDDEQFV 171 +N + H D+KP NI+ V + D +SV ++ DFG+A D E Sbjct: 155 HDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSA--TFDHEHHS 212 Query: 172 SLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNK 231 ++ T Y P++ +L + + D+WSIG + G F+ + R + Sbjct: 213 TIVSTRHYRAPEV----IL----ELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDN-REHL 263 Query: 232 EVMYKIITGKPSGAISGVQKAE---NGPIDW 259 +M +I+ PS I +K + G +DW Sbjct: 264 AMMERILGPIPSRMIRKTRKQKYFYRGRLDW 294 >1AD5-A nrPDB Length = 438 Score = 46.6 bits (109), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 41/148 (27%), Positives = 63/148 (42%), Gaps = 11/148 (7%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 74 LG G V+ + K + A+K S V+ + E V+K L H +VKL A+ Sbjct: 190 LGAGQFGEVWMATYNKHTKV-AVKTMKPGSM--SVEAFLAEANVMKTLQHDKLVKLHAV- 245 Query: 75 EETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHR 134 T +I EF GSL L+ + P + + + GM + + +HR Sbjct: 246 --VTKEPIYIITEFMAKGSLLDFLKSDEGS-KQPLPKLIDFSAQIAEGMAFIEQRNYIHR 302 Query: 135 DIKPGNIMRVIGEDGQSVYKLTDFGAAR 162 D++ NI+ V K+ DFG AR Sbjct: 303 DLRAANILV----SASLVCKIADFGLAR 326 >5XD6-A nrPDB Length = 305 Score = 46.6 bits (109), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 57/219 (26%), Positives = 91/219 (41%), Gaps = 29/219 (13%) Query: 14 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAI 73 ++G+G+ VF G K+G AIK + S +P + + ++ +L +N+V L Sbjct: 29 LIGEGSYGRVFYGI-LKSGKAAAIKKLD--SSKQPDQEFLAQVSMVSRLRQENVVALLGY 85 Query: 74 EEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDV---VG---GMNHLR 127 + R VL E+ P GSL+ +L G L + V VG G+ +L Sbjct: 86 CVDGPLR--VLAYEYAPNGSLHDILHGRKGVKGAQPGPVLSWHQRVKIAVGAARGLEYLH 143 Query: 128 ENG---IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDE---QFVSLYGTEEYLH 181 E ++HRDIK N++ + +D V K+ DF + + D + GT Y Sbjct: 144 EKANPHVIHRDIKSSNVL-LFDDD---VAKIADFDLSNQAPDMAARLHSTRVLGTFGYHA 199 Query: 182 PDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLP 220 P+ L D++S GV TG P Sbjct: 200 PEYAMTGTL--------STKSDVYSFGVVLLELLTGRKP 230 >5J0A-A nrPDB Length = 300 Score = 46.2 bits (108), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 60/220 (27%), Positives = 98/220 (44%), Gaps = 25/220 (11%) Query: 15 LGQGATANVFRGRHKKTG---DLFAIKVFNNI--SFLRPVDVQ--MREFEVLKKLNHKNI 67 LG G NV+ + G +A+K N I R V + M E ++LK L+H NI Sbjct: 17 LGFGTGVNVYLMKRSPRGLSHSPWAVKKINPICNDHYRSVYQKRLMDEAKILKSLHHPNI 76 Query: 68 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAY--GLPESEFLIVLRDVVGGMNH 125 V A E L ME+ SL ++EE A P + L V ++ G+ + Sbjct: 77 VGYRAF-TEANDGSLCLAMEYGGEKSLNDLIEERYKASQDPFPAAIILKVALNMARGLKY 135 Query: 126 L-RENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVS----LYGTEEYL 180 L +E ++H DIK N+ VI D +++ K+ D G + L+++ + GTE + Sbjct: 136 LHQEKKLLHGDIKSSNV--VIKGDFETI-KICDVGVSLPLDENMEVTDPEACYIGTEPWK 192 Query: 181 HPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLP 220 + E + D D+++ G+T + T S+P Sbjct: 193 PKEAVEENGVITDK-------ADIFAFGLTLWEMMTLSIP 225 >6FYV-A nrPDB Length = 337 Score = 45.8 bits (107), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 68/277 (24%), Positives = 112/277 (40%), Gaps = 46/277 (16%) Query: 11 LSDILGQGATANVFRG-RHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVK 69 + D LG+GA V H G A+K+ N+ R + E +VL+ LN + Sbjct: 18 IVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYR--EAARSEIQVLEHLNSTDPNS 75 Query: 70 LFAIEE--ETTTRHKVLIMEFCPCG-SLYTVLEEPSNAYGLPESEFLI-----VLRDVVG 121 +F + E H + + F G S Y ++E S LP F I + + Sbjct: 76 VFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENS---FLP---FQIDHIRQMAYQICQ 129 Query: 122 GMNHLRENGIVHRDIKPGNIMRV-----------IGEDGQSV----YKLTDFGAARELED 166 +N L N + H D+KP NI+ V + D +++ K+ DFG+A D Sbjct: 130 SINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSA--TYD 187 Query: 167 DEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEG 226 DE +L T Y P++ +L + D+WSIG G F+ + Sbjct: 188 DEHHSTLVSTRHYRAPEV----IL----ALGWSQPCDVWSIGCILIEYYLGFTVFQTHDS 239 Query: 227 PRRNKEVMYKIITGKPSGAISGVQKAE---NGPIDWS 260 + + +M +I+ P I +K + + +DW Sbjct: 240 -KEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWD 275 >5Y86-A nrPDB Length = 588 Score = 45.8 bits (107), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 51/213 (23%), Positives = 93/213 (43%), Gaps = 15/213 (7%) Query: 14 ILGQGATANVFRGRHKKTGDLFAIK-VFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFA 72 I+G+G+ V R K A+K V N F R ++R E LKK + + + Sbjct: 214 IIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIH 273 Query: 73 IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIV 132 + E T R+ V + LY ++++ + G + ++ ++ L +N I+ Sbjct: 274 MLESFTFRNHVCMAFELLSIDLYELIKK-NKFQGFSVQLVRKFAQSILQSLDALHKNKII 332 Query: 133 HRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRK 192 H D+KP NI+ + G+S K+ DFG++ + ++ + + Y P++ + Sbjct: 333 HCDLKPENIL--LKHHGRSSTKVIDFGSS--CFEYQKLYTYIQSRFYRAPEIILGS---- 384 Query: 193 DHQKKYGATVDLWSIGVTFYHAATGSLPFRPFE 225 +Y +D+WS G TG P P E Sbjct: 385 ----RYSTPIDIWSFGCILAELLTGQ-PLFPGE 412 >6O6Q-A nrPDB Length = 335 Score = 45.4 bits (106), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 54/230 (23%), Positives = 97/230 (42%), Gaps = 34/230 (14%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQM--REFEVLKKL-NHKNIVKLF 71 LG+G + VF G + + IKV L+PV + RE +LK L + NI+ + Sbjct: 49 LGRGKYSEVFLGIDLEKREKVVIKV------LKPVKRKKIKREISILKNLVDGPNIIAML 102 Query: 72 AIEEETTTRHKVLIMEFC---PCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE 128 + E ++ LI E SLY + + + +++ +++ Sbjct: 103 DVVREPQSKTPGLIFEHINNIDFRSLYPTFTD---------YDIRFYMYELLKALDYSHS 153 Query: 129 NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERA 188 GI+HRD+KP N+M I D + + +L D+G A ++ + + P++ Sbjct: 154 MGIMHRDVKPHNVM--IDHD-KKLLRLIDWGLAEYYHPGTEYNVRVASRYFKGPELLVDY 210 Query: 189 VLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKII 238 L Y ++D+WS G PF F G + N + + +I+ Sbjct: 211 RL-------YDYSLDMWSFGCMLASMVFMKEPF--FHG-KSNTDQLVQIV 250 >5CLR-A nrPDB Length = 451 Score = 45.4 bits (106), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 26/74 (35%), Positives = 38/74 (51%), Gaps = 6/74 (8%) Query: 111 EFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQF 170 E L ++ V + E G++HRD+KPGNIM D L DFG++ D E Sbjct: 177 EVLGIMISVCHQVKQFHELGLIHRDLKPGNIML----DADMQCHLVDFGSSS--SDKEPK 230 Query: 171 VSLYGTEEYLHPDM 184 + +GT YL P++ Sbjct: 231 PASWGTASYLAPEL 244 >2Y4I-B nrPDB Length = 319 Score = 45.1 bits (105), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 62/257 (24%), Positives = 124/257 (48%), Gaps = 39/257 (15%) Query: 11 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREF--EVL--KKLNHKN 66 + +++G+G V+ GR G++ AI++ I R + Q++ F EV+ ++ H+N Sbjct: 37 IGELIGKGRFGQVYHGRWH--GEV-AIRL---IDIERDNEDQLKAFKREVMAYRQTRHEN 90 Query: 67 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 126 +V LF + + H +I C +LY+V+ + + ++ + +++V GM +L Sbjct: 91 VV-LF-MGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTR--QIAQEIVKGMGYL 146 Query: 127 RENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFG--------AARELEDDEQFVSLYGTEE 178 GI+H+D+K N V ++G+ V +TDFG A ED + + G Sbjct: 147 HAKGILHKDLKSKN---VFYDNGKVV--ITDFGLFSISGVLQAGRREDKLRIQN--GWLC 199 Query: 179 YLHPDMYERAVLRKDHQK-KYGATVDLWSIGVTFYHAATGSLPFR--PFEGPRRNKEVMY 235 +L P++ + + K + D++++G +Y PF+ P E +++ Sbjct: 200 HLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEA------IIW 253 Query: 236 KIITG-KPSGAISGVQK 251 ++ TG KP+ + G+ K Sbjct: 254 QMGTGMKPNLSQIGMGK 270 >3RAW-A nrPDB Length = 381 Score = 44.7 bits (104), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 70/298 (23%), Positives = 119/298 (39%), Gaps = 38/298 (12%) Query: 15 LGQGATANVFRG-RHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLF-- 71 LG+G V H + A+K+ N+ R + E VLKK+ K+ F Sbjct: 59 LGEGTFGKVVECLDHARGKSQVALKIIRNVGKYR--EAARLEINVLKKIKEKDKENKFLC 116 Query: 72 AIEEETTTRHKVLIMEFCPCG-SLYTVLEEPS-NAYGLPESEFLIVLRDVVGGMNHLREN 129 + + H + + F G + + L+E + Y LP + + + L EN Sbjct: 117 VLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAY--QLCHALRFLHEN 174 Query: 130 GIVHRDIKPGNIMRVIGE-----------DGQSV----YKLTDFGAARELEDDEQFVSLY 174 + H D+KP NI+ V E + +SV ++ DFG+A D E ++ Sbjct: 175 QLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSA--TFDHEHHTTIV 232 Query: 175 GTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVM 234 T Y P++ +L + + D+WSIG + G F+ E R + +M Sbjct: 233 ATRHYRPPEV----IL----ELGWAQPCDVWSIGCILFEYYRGFTLFQTHEN-REHLVMM 283 Query: 235 YKIITGKPSGAISGVQKAE---NGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQ 289 KI+ PS I +K + G + W + + + L + +L + LE Q Sbjct: 284 EKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQ 341 >3REP-A nrPDB Length = 271 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 38/165 (23%), Positives = 63/165 (38%), Gaps = 16/165 (9%) Query: 59 LKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRD 118 L+ +H N++ + + H LI + P GSLY VL E +N + + +S+ + D Sbjct: 61 LRIFSHPNVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTN-FVVDQSQAVKFALD 119 Query: 119 VVGGMN--HLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGT 176 + GM H E I + ++M I ED + + D S Sbjct: 120 MARGMAFLHTLEPLIPRHALNSRSVM--IDEDMTARISMADVK-----------FSFQSP 166 Query: 177 EEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 P L+K + + D+WS V + T +PF Sbjct: 167 GRMYAPAWVAPEALQKKPEDTNRRSADMWSFAVLLWELVTREVPF 211 >5X18-A nrPDB Length = 295 Score = 43.9 bits (102), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 79/310 (25%), Positives = 133/310 (42%), Gaps = 63/310 (20%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMR-EFEVLKKLNH-KNIVKLFA 72 +G+G+ +F G + G AIK F P Q+R E++ K LN NI + Sbjct: 15 IGEGSFGVLFEGTNMINGVPVAIK-FEPRKTEAP---QLRDEYKTYKILNGTPNIPYAYY 70 Query: 73 IEEETTTRHKVLIME---------FCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 123 +E H +L+++ F CG ++V + V ++ + Sbjct: 71 FGQEGL--HNILVIDLLGPSLEDLFDWCGRKFSV------------KTVVQVAVQMITLI 116 Query: 124 NHLRENGIVHRDIKPGNIMRVIGEDGQ---SVYKLTDFGAARELEDD--EQFV------S 172 L + +++RDIKP N + IG GQ + L DFG A++ D +Q + S Sbjct: 117 EDLHAHDLIYRDIKPDNFL--IGRPGQPDANNIHLIDFGMAKQYRDPKTKQHIPYREKKS 174 Query: 173 LYGTEEYLHPDMY-ERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNK 231 L GT Y+ + + R R+D D+ ++G F++ G LP++ + P NK Sbjct: 175 LSGTARYMSINTHLGREQSRRD---------DMEALGHVFFYFLRGHLPWQGLKAP-NNK 224 Query: 232 EVMYKIITGKPSGAISGVQKAENGPIDWSGDMPVSCSLS-------RGLQVLLTPVLANI 284 + KI K S + + A+ P+ + + + SLS G + LL VL ++ Sbjct: 225 QKYEKIGEKKRSTNVYDL--AQGLPVQFGRYLEIVRSLSFEECPDYEGYRKLLLSVLDDL 282 Query: 285 LE-ADQEKCW 293 E AD + W Sbjct: 283 GETADGQYDW 292 >5XVU-A nrPDB Length = 332 Score = 43.5 bits (101), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 34/156 (21%), Positives = 66/156 (42%), Gaps = 16/156 (10%) Query: 66 NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 125 NI+KL I ++ T+ LI E+ T+ + + + + ++ +++ Sbjct: 87 NIIKLLDIVKDPVTKTPSLIFEYINNIDFKTLYPK------FTDKDIRYYIYQILKALDY 140 Query: 126 LRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMY 185 GI+HRD+KP NIM I + + + +L +G A +++ + Y P++ Sbjct: 141 CHSQGIMHRDVKPHNIM--IDHENRQI-RLISWGLAEFYHPGQEYNVRVASRYYKGPELL 197 Query: 186 ERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 L Y ++D+WS+G PF Sbjct: 198 IDLQL-------YDYSLDIWSLGCMLAGMIFKKEPF 226 >4IX6-A nrPDB Length = 350 Score = 43.1 bits (100), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 20/47 (42%), Positives = 29/47 (61%), Gaps = 2/47 (4%) Query: 115 VLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAA 161 +R+++G + L E G+VHRD+KP N+ + E V KL D GAA Sbjct: 148 AMRELLGSLARLHECGVVHRDVKPANL--IAAEKDGGVLKLIDLGAA 192 >4LFI-A nrPDB Length = 374 Score = 42.7 bits (99), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 40/177 (22%), Positives = 79/177 (44%), Gaps = 23/177 (12%) Query: 64 HKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 123 H NI+ LF I ++ ++ L+ E+ + + L + E + +++ + Sbjct: 132 HANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPK------LTDLEIRFYMFELLKAL 185 Query: 124 NHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPD 183 ++ GI+HRD+KP N+M I + + +L D+G A + ++ + + P+ Sbjct: 186 DYCHSMGIMHRDVKPHNVM--IDHKNKKL-RLIDWGLAEFYHVNMEYNVRVASRFFKGPE 242 Query: 184 MYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFR--PFEGPRRNKEVMYKII 238 L D+ + Y ++DLWS G S+ F+ PF N + + KI+ Sbjct: 243 ------LLVDY-RMYDYSLDLWSFGTML-----ASMIFKREPFFHGTSNTDQLVKIV 287 >4TPT-A nrPDB Length = 303 Score = 42.4 bits (98), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 47/225 (20%), Positives = 91/225 (40%), Gaps = 47/225 (20%) Query: 12 SDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREF----EVLKKLNHKNI 67 ++LG+G + HK TG + +K +R + + F +V++ L+H N+ Sbjct: 5 GEVLGKGFFGQAIKVTHKATGKVMVMK-----ELIRCDEETQKTFLTEVKVMRSLDHPNV 59 Query: 68 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 127 +K + + + L+ E+ G+L L + P + + + + GM +L Sbjct: 60 LKFIGVLYKDKKLN--LLTEYIEGGTLKDFLR---SMDPFPWQQKVRFAKGIASGMAYLH 114 Query: 128 ENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAAREL---------------------ED 166 I+HRD+ N + I D V + DFG +R + D Sbjct: 115 SMCIIHRDLNSHNCL--IKLDKTVV--VADFGLSRLIVEERKRAPMEKATTKKRTLRKND 170 Query: 167 DEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTF 211 ++ ++ G ++ P+M + K Y TVD++S G+ Sbjct: 171 RKKRYTVVGNPYWMAPEML--------NGKSYDETVDIFSFGIVL 207 >6FER-A nrPDB Length = 309 Score = 42.4 bits (98), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 43/178 (24%), Positives = 73/178 (41%), Gaps = 32/178 (17%) Query: 53 MREFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLE--EPSNAYG---- 106 ++E +++ +L NI+ L A+ T +I E+ G L L EP N+ Sbjct: 71 LKEIKIMSRLKDPNIIHLLAVC--ITDDPLCMITEYMENGDLNQFLSRHEPPNSSSSDVR 128 Query: 107 -LPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELE 165 + + + + GM +L VHRD+ N + +G++ K+ DFG +R Sbjct: 129 TVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCL--VGKN--YTIKIADFGMSR--- 181 Query: 166 DDEQFVSLYGTEEYLHPDMYERAVLRKDHQK-------KYGATVDLWSIGVTFYHAAT 216 +LY + Y + RAVL K+ D+W+ GVT + T Sbjct: 182 ------NLYSGDYY---RIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFT 230 >4BTK-A nrPDB Length = 337 Score = 42.4 bits (98), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 55/222 (24%), Positives = 85/222 (38%), Gaps = 23/222 (10%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIV 68 W + +G G ++ T + A+KV S +P V E VLKKL K+ V Sbjct: 58 WKVLKKIGGGGFGEIYEAMDLLTRENVALKV---ESAQQPKQVLKMEVAVLKKLQGKDHV 114 Query: 69 KLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE 128 F I + ++M+ +P + L S L + + ++ + + Sbjct: 115 CRF-IGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTL--STTLRLGKQILESIEAIHS 171 Query: 129 NGIVHRDIKPGNI-MRVIGEDGQSVYKLTDFGAARE-------LEDDEQFVSLYGTEEYL 180 G +HRDIKP N M + + Y L DFG AR+ + GT Y Sbjct: 172 VGFLHRDIKPSNFAMGRLPSTYRKCYML-DFGLARQYTNTTGDVRPPRNVAGFRGTVRY- 229 Query: 181 HPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFR 222 A + ++ G DLWS+ A G LP+R Sbjct: 230 -------ASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWR 264 >5VC6-A nrPDB Length = 289 Score = 42.0 bits (97), Expect = 9e-04, Method: Compositional matrix adjust. Identities = 35/136 (25%), Positives = 61/136 (44%), Gaps = 15/136 (11%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKL-------NHKNI 67 +G G +VF+ + G ++AIK +P+ + E L+++ H ++ Sbjct: 19 IGSGEFGSVFKCVKRLDGCIYAIKRSK-----KPLAGSVDEQNALREVYAHAVLGQHSHV 73 Query: 68 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYG-LPESEFLIVLRDVVGGMNHL 126 V+ F+ E H ++ E+C GSL + E E+E +L V G+ ++ Sbjct: 74 VRYFSAWAEDD--HMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYI 131 Query: 127 RENGIVHRDIKPGNIM 142 +VH DIKP NI Sbjct: 132 HSMSLVHMDIKPSNIF 147 >4NFN-A nrPDB Length = 309 Score = 42.0 bits (97), Expect = 9e-04, Method: Compositional matrix adjust. Identities = 55/222 (24%), Positives = 85/222 (38%), Gaps = 23/222 (10%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIV 68 W + +G G ++ T + A+KV S +P V E VLKKL K+ V Sbjct: 23 WKVLKKIGGGGFGEIYEAMDLLTRENVALKV---ESAQQPKQVLKMEVAVLKKLQGKDHV 79 Query: 69 KLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE 128 F I + ++M+ +P + L S L + + ++ + + Sbjct: 80 CRF-IGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTL--STTLRLGKQILESIEAIHS 136 Query: 129 NGIVHRDIKPGNI-MRVIGEDGQSVYKLTDFGAARE-------LEDDEQFVSLYGTEEYL 180 G +HRDIKP N M + + Y L DFG AR+ + GT Y Sbjct: 137 VGFLHRDIKPSNFAMGRLPSTYRKCYML-DFGLARQYTNTTGDVRPPRNVAGFRGTVRY- 194 Query: 181 HPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFR 222 A + ++ G DLWS+ A G LP+R Sbjct: 195 -------ASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWR 229 >4XCU-A nrPDB Length = 300 Score = 42.0 bits (97), Expect = 9e-04, Method: Compositional matrix adjust. Identities = 52/229 (22%), Positives = 95/229 (41%), Gaps = 32/229 (13%) Query: 10 LLSDILGQGATANVFRGR-------HKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKL 62 +L LG+G V R A+K+ + + + + + E EV+K + Sbjct: 20 VLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLI 79 Query: 63 N-HKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLE---EPSNAYGLPESEFLI-VLR 117 HKNI+ L + + + +I+E G+L L P ++ G L+ Sbjct: 80 GRHKNIINLLGVCTQEGPLY--VIVECAAKGNLREFLRARRPPGSSEGPLSFPVLVSCAY 137 Query: 118 DVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTE 177 V GM +L +HRD+ N++ + ED +V K+ DFG AR + + + Sbjct: 138 QVARGMQYLESRKCIHRDLAARNVL--VTED--NVMKIADFGLARGVHHIDYYKKTSNGR 193 Query: 178 ---EYLHPD-MYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPF 221 +++ P+ +++R Y D+WS G+ + T G P+ Sbjct: 194 LPVKWMAPEALFDRV---------YTHQSDVWSFGILLWEIFTLGGSPY 233 >3UIM-A nrPDB Length = 326 Score = 42.0 bits (97), Expect = 0.001, Method: Compositional matrix adjust. Identities = 53/218 (24%), Positives = 99/218 (45%), Gaps = 27/218 (12%) Query: 13 DILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMR-EFEVLKKLNHKNIVKLF 71 +ILG+G V++GR G L A+K + ++Q + E E++ H+N+++L Sbjct: 36 NILGRGGFGKVYKGRLAD-GTLVAVKRLKE-ERTQGGELQFQTEVEMISMAVHRNLLRLR 93 Query: 72 AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVG---GMNHLRE 128 T R +L+ + GS+ + L E + P ++ R +G G+ +L + Sbjct: 94 GFCMTPTER--LLVYPYMANGSVASCLRERPESQ--PPLDWPKRQRIALGSARGLAYLHD 149 Query: 129 N---GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAAR--ELEDDEQFVSLYGTEEYLHPD 183 + I+HRD+K NI+ + E+ ++V + DFG A+ + +D ++ GT ++ P+ Sbjct: 150 HCDPKIIHRDVKAANIL--LDEEFEAV--VGDFGLAKLMDYKDTHVTTAVRGTIGHIAPE 205 Query: 184 MYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 K D++ GV TG F Sbjct: 206 YLSTG--------KSSEKTDVFGYGVMLLELITGQRAF 235 >5OAT-A nrPDB Length = 411 Score = 42.0 bits (97), Expect = 0.001, Method: Compositional matrix adjust. Identities = 33/122 (27%), Positives = 50/122 (40%), Gaps = 12/122 (9%) Query: 122 GMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLH 181 G+ H+ +GI HRD+K N++ E + ++DFG L D +SL T + Sbjct: 165 GVAHMTAHGIAHRDLKSDNLLLDTSEPESPILVISDFGCC--LADKTNGLSLPYTSYEMD 222 Query: 182 PDMYERAVLRKDHQKKYG-------ATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVM 234 + + +K G + DLW++G Y PF GP R K Sbjct: 223 KGGNTALMAPEIICQKPGTFSVLNYSKADLWAVGAIAYEIFNCH---NPFYGPSRLKNFN 279 Query: 235 YK 236 YK Sbjct: 280 YK 281 >4LQP-A nrPDB Length = 508 Score = 42.0 bits (97), Expect = 0.001, Method: Compositional matrix adjust. Identities = 39/148 (26%), Positives = 67/148 (45%), Gaps = 11/148 (7%) Query: 14 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHKNIVKLF 71 ++G+GA V + K TG ++A+K + + E +VL + +V L+ Sbjct: 109 VIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKDQLAHVKAERDVLAGSDSPWVVSLY 168 Query: 72 AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGI 131 ++ ++ LIMEF P G L T+L E + + + + + + G Sbjct: 169 YSFQDA--QYLYLIMEFLPGGDLMTML---IRWQLFTEDVTRFYMAECILAIETIHKLGF 223 Query: 132 VHRDIKPGNIMRVIGEDGQSVYKLTDFG 159 +HR IKP NI+ D + KL+DFG Sbjct: 224 IHRAIKPDNILI----DIRGHIKLSDFG 247 Score = 30.4 bits (67), Expect = 2.8, Method: Compositional matrix adjust. Identities = 15/50 (30%), Positives = 22/50 (44%), Gaps = 8/50 (16%) Query: 172 SLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 S GT +Y+ P+++ + YG D WS+G Y G PF Sbjct: 322 STVGTPDYIAPEIF--------LYQGYGQECDWWSLGAIMYECLIGWPPF 363 >2CHL-A nrPDB Length = 351 Score = 42.0 bits (97), Expect = 0.001, Method: Compositional matrix adjust. Identities = 42/156 (26%), Positives = 72/156 (46%), Gaps = 31/156 (19%) Query: 88 FCPCGSLYTVLEE---PS--NAYGLPESEF-----LIVLRDVVGGMNHLRENGIVHRDIK 137 F PCG ++ E PS + + L + F L++ ++ M ++ +++RD+K Sbjct: 94 FGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVK 153 Query: 138 PGNIMRVIGEDG---QSVYKLTDFGAARELEDDE--------QFVSLYGTEEYLHPDMYE 186 P N + IG G Q V + DF A+E D E + SL GT Y+ + + Sbjct: 154 PENFL--IGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTH- 210 Query: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFR 222 L K+ ++ DL ++G F + GSLP++ Sbjct: 211 ---LGKEQSRR----DDLEALGHMFMYFLRGSLPWQ 239 >2CMW-A nrPDB Length = 310 Score = 42.0 bits (97), Expect = 0.001, Method: Compositional matrix adjust. Identities = 42/159 (26%), Positives = 74/159 (46%), Gaps = 31/159 (19%) Query: 85 IMEFCPCGSLYTVLEE---PS--NAYGLPESEF-----LIVLRDVVGGMNHLRENGIVHR 134 + F PCG ++ E PS + + L + F L++ ++ M ++ +++R Sbjct: 62 VYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYVHSKNLIYR 121 Query: 135 DIKPGNIMRVIGEDG---QSVYKLTDFGAARELEDDE--------QFVSLYGTEEYLHPD 183 D+KP N + IG G + V + DFG A+E D E + SL GT Y+ + Sbjct: 122 DVKPENFL--IGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSIN 179 Query: 184 MYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFR 222 + L K+ ++ DL ++G F + GSLP++ Sbjct: 180 TH----LGKEQSRR----DDLEALGHMFMYFLRGSLPWQ 210 >5M07-A nrPDB Length = 276 Score = 42.0 bits (97), Expect = 0.001, Method: Compositional matrix adjust. Identities = 18/57 (31%), Positives = 30/57 (52%) Query: 107 LPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARE 163 LP E L ++ V G +++ + G++HRD+ P N++ G L DFG A + Sbjct: 129 LPVGEVLAIVTAVAGALDYAHQRGLLHRDVNPANVVLTSQSAGDQRILLADFGIASQ 185 >6HMD-A nrPDB Length = 365 Score = 41.6 bits (96), Expect = 0.001, Method: Compositional matrix adjust. Identities = 39/177 (22%), Positives = 78/177 (44%), Gaps = 29/177 (16%) Query: 66 NIVKLFAIEEETTTRHKVLIMEF---CPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGG 122 NI+KL ++ ++ L+ E+ LY +L + + + +++ Sbjct: 109 NIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTD---------FDIRFYMYELLKA 159 Query: 123 MNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHP 182 +++ GI+HRD+KP N+M + Q +L D+G A +++ + + P Sbjct: 160 LDYCHSKGIMHRDVKPHNVMI---DHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGP 216 Query: 183 DMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFR--PFEGPRRNKEVMYKI 237 + L D+Q Y ++D+WS+G S+ FR PF + N + + +I Sbjct: 217 E------LLVDYQ-MYDYSLDMWSLGCML-----ASMIFRREPFFHGQDNYDQLVRI 261 >3ZZW-A nrPDB Length = 289 Score = 41.6 bits (96), Expect = 0.001, Method: Compositional matrix adjust. Identities = 45/193 (23%), Positives = 84/193 (43%), Gaps = 27/193 (13%) Query: 48 PVDVQMREFEVLK-KLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSL--YTVLEEPSNA 104 P+ + R +L+ +L H N+V L + T + +I +C G L + V+ P + Sbjct: 54 PLREEFRHEAMLRARLQHPNVVCLLGVV--TKDQPLSMIFSYCSHGDLHEFLVMRSPHSD 111 Query: 105 YG-----------LPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVY 153 G L +F+ ++ + GM +L + +VH+D+ N++ D +V Sbjct: 112 VGSTDDDRTVKSALEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVY---DKLNV- 167 Query: 154 KLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYH 213 K++D G RE+ + + L G M A++ K+ D+WS GV + Sbjct: 168 KISDLGLFREVYAAD-YYKLLGNSLLPIRWMAPEAIM----YGKFSIDSDIWSYGVVLWE 222 Query: 214 AATGSLPFRPFEG 226 + L +P+ G Sbjct: 223 VFSYGL--QPYCG 233 >4F9B-A nrPDB Length = 361 Score = 41.2 bits (95), Expect = 0.002, Method: Compositional matrix adjust. Identities = 31/128 (24%), Positives = 50/128 (39%), Gaps = 29/128 (22%) Query: 118 DVVGGMNHLRENGIVHRDIKPGNIM--RVIGEDGQSVYKLTDFGAARELEDDE----QFV 171 ++ + + + GIVHRD+KP N + R + + Y L DFG A+ D + +FV Sbjct: 125 NLFKALKRIHQFGIVHRDVKPSNFLYNRRLKK-----YALVDFGLAQGTHDTKIELLKFV 179 Query: 172 SLYGTEEYLHPDMYERAVLRKDHQKKYGAT------------------VDLWSIGVTFYH 213 +E + + R+ T +D+WS GV F Sbjct: 180 QSEAQQERCSQNKCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLS 239 Query: 214 AATGSLPF 221 +G PF Sbjct: 240 LLSGRYPF 247 >5VDK-A nrPDB Length = 297 Score = 41.2 bits (95), Expect = 0.002, Method: Compositional matrix adjust. Identities = 54/237 (22%), Positives = 100/237 (42%), Gaps = 51/237 (21%) Query: 15 LGQGATANVFRGRHKKTGDLFAIK----VFNNISFLRPVDVQMREFEVLKKLNHKNIVKL 70 +G G V++ + G ++AIK F +S ++ VL +H ++V+ Sbjct: 23 IGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSALHEVYAHAVLG--HHPHVVRY 80 Query: 71 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYG-LPESEFLIVLRDVVGGMNHLREN 129 ++ E H ++ E+C GSL + E + + E + +L + G+N++ + Sbjct: 81 YSSWAEDD--HMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQISLGLNYIHNS 138 Query: 130 GIVHRDIKPGNIM----------RVIGE---------DGQSVYKLTDFGAAREL------ 164 +VH DIKP NI VI E +YK+ D G A + Sbjct: 139 SMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGDLGHATSINKPKVE 198 Query: 165 EDDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATG-SLP 220 E D +F++ +L++D+ ++ D++++G+T AA SLP Sbjct: 199 EGDSRFLA--------------NEILQEDY--RHLPKADIFALGLTIAVAAGAESLP 239 >4K33-A nrPDB Length = 325 Score = 40.8 bits (94), Expect = 0.002, Method: Compositional matrix adjust. Identities = 47/205 (22%), Positives = 91/205 (44%), Gaps = 34/205 (16%) Query: 36 AIKVFNNISFLRPVDVQMREFEVLKKLN-HKNIVKLFAIEEETTTRHKVLIMEFCPCGSL 94 A+K+ + + + + + E E++K + HKNI+ L + + +++E+ G+L Sbjct: 72 AVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLY--VLVEYAAKGNL 129 Query: 95 YTVLE---EPSNAYGLPES---EFLIVLRDVVG-------GMNHLRENGIVHRDIKPGNI 141 L P Y S E + +D+V GM +L +HRD+ N+ Sbjct: 130 REFLRARRPPGLDYSFDTSKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNV 189 Query: 142 MRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTE---EYLHPD-MYERAVLRKDHQKK 197 + + ED +V K+ DFG AR++ + + + +++ P+ +++R Sbjct: 190 L--VTED--NVMKIADFGLARDVHNLDYYKETTNGRLPVKWMAPEALFDRV--------- 236 Query: 198 YGATVDLWSIGVTFYHAAT-GSLPF 221 Y D+WS GV + T G P+ Sbjct: 237 YTHQSDVWSFGVLLWEIFTLGGSPY 261 >2PSQ-A nrPDB Length = 370 Score = 40.8 bits (94), Expect = 0.002, Method: Compositional matrix adjust. Identities = 47/207 (22%), Positives = 93/207 (44%), Gaps = 38/207 (18%) Query: 36 AIKVFNNISFLRPVDVQMREFEVLKKLN-HKNIVKLFAIEEETTTRHKVLIMEFCPCGSL 94 A+K+ + + + + + E E++K + HKNI+ L + + +I+E+ G+L Sbjct: 117 AVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLY--VIVEYASKGNL 174 Query: 95 YTVLE---EPSNAYG-----LPESEFLIVLRDVVG-------GMNHLRENGIVHRDIKPG 139 L P Y +PE + + +D+V GM +L +HRD+ Sbjct: 175 REYLRARRPPGMEYSYDINRVPEEQ--MTFKDLVSCTYQLARGMEYLASQKCIHRDLAAR 232 Query: 140 NIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTE---EYLHPD-MYERAVLRKDHQ 195 N++ + E+ +V K+ DFG AR++ + + + +++ P+ +++R Sbjct: 233 NVL--VTEN--NVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRV------- 281 Query: 196 KKYGATVDLWSIGVTFYHAAT-GSLPF 221 Y D+WS GV + T G P+ Sbjct: 282 --YTHQSDVWSFGVLMWEIFTLGGSPY 306 >2PVN-A nrPDB Length = 352 Score = 40.8 bits (94), Expect = 0.002, Method: Compositional matrix adjust. Identities = 44/174 (25%), Positives = 81/174 (46%), Gaps = 23/174 (13%) Query: 66 NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 125 NIVKL I + ++ LI E+ + + VL P+ L + + + +++ +++ Sbjct: 108 NIVKLLDIVRDQHSKTPSLIFEYV-NNTDFKVLY-PT----LTDYDIRYYIYELLKALDY 161 Query: 126 LRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMY 185 GI+HRD+KP N+M I + + + +L D+G A +++ + + P+ Sbjct: 162 CHSQGIMHRDVKPHNVM--IDHELRKL-RLIDWGLAEFYHPGKEYNVRVASRYFKGPE-- 216 Query: 186 ERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFR--PFEGPRRNKEVMYKI 237 L D Q Y ++D+WS+G F + FR PF N + + KI Sbjct: 217 ----LLVDLQ-DYDYSLDMWSLGCMF-----AGMIFRKEPFFYGHDNHDQLVKI 260 >2C47-A nrPDB Length = 313 Score = 40.8 bits (94), Expect = 0.002, Method: Compositional matrix adjust. Identities = 41/159 (25%), Positives = 73/159 (45%), Gaps = 31/159 (19%) Query: 85 IMEFCPCGSLYTVLEE---PS--NAYGLPESEF-----LIVLRDVVGGMNHLRENGIVHR 134 + F PCG ++ E PS + + L + F L++ ++ M ++ +++R Sbjct: 65 VYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYVHTKSLIYR 124 Query: 135 DIKPGNIMRVIGEDG---QSVYKLTDFGAARELEDDE--------QFVSLYGTEEYLHPD 183 D+KP N + +G G Q + DFG A+E D E + SL GT Y+ + Sbjct: 125 DVKPENFL--VGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSIN 182 Query: 184 MYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFR 222 + L K+ ++ DL ++G F + GSLP++ Sbjct: 183 TH----LGKEQSRR----DDLEALGHMFMYFLRGSLPWQ 213 >3QD2-B nrPDB Length = 332 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 27/113 (23%), Positives = 49/113 (43%), Gaps = 25/113 (22%) Query: 113 LIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVS 172 L + + + L G++HRD+KP NI + + V K+ DFG ++ DE+ + Sbjct: 167 LHIFIQIAEAVEFLHSKGLMHRDLKPSNIFFTMDD----VVKVGDFGLVTAMDQDEEEQT 222 Query: 173 LY-------------GTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFY 212 + GT+ Y+ P+ H Y VD++S+G+ + Sbjct: 223 VLTPMPAYATHTGQVGTKLYMSPEQI--------HGNNYSHKVDIFSLGLILF 267 >3SV0-A nrPDB Length = 483 Score = 40.0 bits (92), Expect = 0.004, Method: Compositional matrix adjust. Identities = 53/235 (22%), Positives = 102/235 (43%), Gaps = 34/235 (14%) Query: 1 MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLK 60 M+ + + L +G G+ ++ G + +T + AIK+ N + + + + + +L+ Sbjct: 1 MEPRVGNKFRLGRKIGSGSFGEIYLGTNIQTNEEVAIKLENVKTKHPQLLYESKIYRILQ 60 Query: 61 KLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSN--AYGLPESEFLIVLRD 118 V+ F +E + + VL+M+ L LE+ N + L L++ Sbjct: 61 GGTGIPNVRWFGVEGD----YNVLVMDL-----LGPSLEDLFNFCSRKLSLKTVLMLADQ 111 Query: 119 VVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD--------EQF 170 ++ + + +HRDIKP N + +G VY + DFG A++ D + Sbjct: 112 MINRVEFVHSKSFLHRDIKPDNFLMGLGRRANQVY-IIDFGLAKKYRDTSTHQHIPYREN 170 Query: 171 VSLYGTEEYLHPDMY---ERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFR 222 +L GT Y + + E++ R+D DL S+G + GSLP++ Sbjct: 171 KNLTGTARYASVNTHLGIEQS--RRD---------DLESLGYVLMYFLRGSLPWQ 214 >4RT7-A nrPDB Length = 415 Score = 40.0 bits (92), Expect = 0.004, Method: Compositional matrix adjust. Identities = 34/132 (25%), Positives = 53/132 (40%), Gaps = 17/132 (12%) Query: 98 LEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTD 157 LEE + L + L V GM L VHRD+ N++ G+ V K+ D Sbjct: 231 LEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGK----VVKICD 286 Query: 158 FGAARELEDDEQFVSLYGTE---EYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHA 214 FG AR++ D +V +++ P+ + Y D+WS G+ + Sbjct: 287 FGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGI--------YTIKSDVWSYGILLWEI 338 Query: 215 ATGSLPFRPFEG 226 SL P+ G Sbjct: 339 F--SLGVNPYPG 348 >2WTK-B nrPDB Length = 373 Score = 39.7 bits (91), Expect = 0.005, Method: Compositional matrix adjust. Identities = 57/233 (24%), Positives = 100/233 (42%), Gaps = 44/233 (18%) Query: 11 LSDILGQG----ATANVFRGRHKKTGDLFAIKVFN-------NISFLRPVDVQMREFEVL 59 L ++G+G T N+ R+K TG+ ++ N ++FL+ E V Sbjct: 13 LLTVIGKGFEDLMTVNL--ARYKPTGEYVTVRRINLEACSNEMVTFLQ------GELHVS 64 Query: 60 KKLNHKNIVKL---FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVL 116 K NH NIV F + E ++ F GS ++ G+ E +L Sbjct: 65 KLFNHPNIVPYRATFIADNELW-----VVTSFMAYGSAKDLICT-HFMDGMNELAIAYIL 118 Query: 117 RDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQ-------SVYKLTDFGAARELEDDEQ 169 + V+ ++++ G VHR +K +I+ I DG+ S + G + + D Sbjct: 119 QGVLKALDYIHHMGYVHRSVKASHIL--ISVDGKVYLSGLRSNLSMISHGQRQRVVHDFP 176 Query: 170 FVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFR 222 S+ +L P+ VL+++ Q Y A D++S+G+T A G +PF+ Sbjct: 177 KYSV-KVLPWLSPE-----VLQQNLQG-YDAKSDIYSVGITACELANGHVPFK 222 >5EG3-A nrPDB Length = 334 Score = 39.7 bits (91), Expect = 0.005, Method: Compositional matrix adjust. Identities = 53/237 (22%), Positives = 98/237 (41%), Gaps = 41/237 (17%) Query: 11 LSDILGQGATANVFRGR-------HKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLN 63 L LG+GA V K A+K+ + + + + + E E++K + Sbjct: 39 LGKPLGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIG 98 Query: 64 -HKNIVKLFAIEEETTTRHKVLIMEFCPCGSL--YTVLEEPSNAYGLPE----SEFLIVL 116 HKNI+ L + + +I+ + G+L Y P P+ E + Sbjct: 99 KHKNIINLLGACTQDGPLY--VIVAYASKGNLREYLRARRPPGMELSPDINRVPEEQMTF 156 Query: 117 RDVVG-------GMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQ 169 +D+V GM +L +HRD+ N++ + E+ +V K+ DFG AR++ + + Sbjct: 157 KDLVSCTYQLARGMEYLASQKCIHRDLAARNVL--VTEN--NVMKIADFGLARDINNIDF 212 Query: 170 FVSLYGTE---EYLHPD-MYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPF 221 F +++ P+ +++R Y D+WS GV + T G P+ Sbjct: 213 FKETTNGRLPVKWMAPEALFDRV---------YTHQSDVWSFGVLMWEIFTLGGSPY 260 >3VHK-A nrPDB Length = 368 Score = 39.7 bits (91), Expect = 0.005, Method: Compositional matrix adjust. Identities = 33/126 (26%), Positives = 58/126 (46%), Gaps = 19/126 (15%) Query: 119 VVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTE- 177 V GM L +HRD+ NI+ + E ++V K+ DFG AR++ D +V Sbjct: 209 VAKGMEFLASRKCIHRDLAARNIL--LSE--KNVVKICDFGLARDIYKDPDYVRKGDARL 264 Query: 178 --EYLHPD-MYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVM 234 +++ P+ +++R Y D+WS GV + SL P+ G + ++E Sbjct: 265 PLKWMAPETIFDRV---------YTIQSDVWSFGVLLWEIF--SLGASPYPGVKIDEEFC 313 Query: 235 YKIITG 240 ++ G Sbjct: 314 RRLKEG 319 >3TT0-A nrPDB Length = 382 Score = 39.3 bits (90), Expect = 0.005, Method: Compositional matrix adjust. Identities = 46/205 (22%), Positives = 88/205 (42%), Gaps = 34/205 (16%) Query: 36 AIKVFNNISFLRPVDVQMREFEVLKKLN-HKNIVKLFAIEEETTTRHKVLIMEFCPCGSL 94 A+K+ + + + + + E E++K + HKNI+ L + + +I+E+ G+L Sbjct: 105 AVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLY--VIVEYASKGNL 162 Query: 95 YTVLE---EPSNAYG----------LPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNI 141 L+ P Y L + + V GM +L +HRD+ N+ Sbjct: 163 REYLQARRPPGLEYSYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNV 222 Query: 142 MRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTE---EYLHPD-MYERAVLRKDHQKK 197 + + ED +V K+ DFG AR++ + + +++ P+ +++R Sbjct: 223 L--VTED--NVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRI--------- 269 Query: 198 YGATVDLWSIGVTFYHAAT-GSLPF 221 Y D+WS GV + T G P+ Sbjct: 270 YTHQSDVWSFGVLLWEIFTLGGSPY 294 >3GQL-A nrPDB Length = 326 Score = 39.3 bits (90), Expect = 0.006, Method: Compositional matrix adjust. Identities = 46/205 (22%), Positives = 88/205 (42%), Gaps = 34/205 (16%) Query: 36 AIKVFNNISFLRPVDVQMREFEVLKKLN-HKNIVKLFAIEEETTTRHKVLIMEFCPCGSL 94 A+K+ + + + + + E E++K + HKNI+ L + + +I+E+ G+L Sbjct: 64 AVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLY--VIVEYASKGNL 121 Query: 95 YTVLE---EPSNAYG----------LPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNI 141 L+ P Y L + + V GM +L +HRD+ N+ Sbjct: 122 REYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNV 181 Query: 142 MRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTE---EYLHPD-MYERAVLRKDHQKK 197 + + ED +V K+ DFG AR++ + + +++ P+ +++R Sbjct: 182 L--VTED--NVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRI--------- 228 Query: 198 YGATVDLWSIGVTFYHAAT-GSLPF 221 Y D+WS GV + T G P+ Sbjct: 229 YTHQSDVWSFGVLLWEIFTLGGSPY 253 >6EII-A nrPDB Length = 352 Score = 39.3 bits (90), Expect = 0.006, Method: Compositional matrix adjust. Identities = 38/174 (21%), Positives = 77/174 (44%), Gaps = 23/174 (13%) Query: 66 NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 125 NI+ L I ++ +R L+ E + + L + + + +++ +++ Sbjct: 116 NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ------TLTDYDIRFYMYEILKALDY 169 Query: 126 LRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMY 185 GI+HRD+KP N+M I + + + +L D+G A +++ + + P+ Sbjct: 170 CHSMGIMHRDVKPHNVM--IDHEHRKL-RLIDWGLAEFYHPGQEYNVRVASRYFKGPE-- 224 Query: 186 ERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFR--PFEGPRRNKEVMYKI 237 L D+Q Y ++D+WS+G S+ FR PF N + + +I Sbjct: 225 ----LLVDYQ-MYDYSLDMWSLGCML-----ASMIFRKEPFFHGHDNYDQLVRI 268 >3SOC-A nrPDB Length = 322 Score = 39.3 bits (90), Expect = 0.006, Method: Compositional matrix adjust. Identities = 52/213 (24%), Positives = 89/213 (41%), Gaps = 35/213 (16%) Query: 55 EFEV--LKKLNHKNIVKLFAIEEETTTRHK--VLIMEFCPCGSLYTVLEEPSNAYGLPE- 109 E+EV L + H+NI++ E+ T+ LI F GSL L+ +N E Sbjct: 66 EYEVYSLPGMKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLK--ANVVSWNEL 123 Query: 110 -------SEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAAR 162 + L L + + G+ + I HRDIK N++ + DFG A Sbjct: 124 CHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLL----KNNLTACIADFGLAL 179 Query: 163 ELEDDEQFVSLY---GTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYH------ 213 + E + + GT Y+ P++ E A+ + Q+ +D++++G+ + Sbjct: 180 KFEAGKSAGDTHGQVGTRRYMAPEVLEGAI---NFQRDAFLRIDMYAMGLVLWELASRCT 236 Query: 214 AATGS-----LPFRPFEGPRRNKEVMYKIITGK 241 AA G LPF G + E M +++ K Sbjct: 237 AADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHK 269 >2QKW-B nrPDB Length = 321 Score = 39.3 bits (90), Expect = 0.007, Method: Compositional matrix adjust. Identities = 27/94 (28%), Positives = 46/94 (48%), Gaps = 15/94 (15%) Query: 122 GMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAAR---ELEDDEQFVSLYGTEE 178 G+++L I+HRD+K NI+ D V K+TDFG ++ EL+ + GT Sbjct: 151 GLHYLHTRAIIHRDVKSINILL----DENFVPKITDFGISKKGTELDQTHLSTVVKGTLG 206 Query: 179 YLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFY 212 Y+ P+ + + L + D++S GV + Sbjct: 207 YIDPEYFIKGRLTEKS--------DVYSFGVVLF 232 >4TN6-A nrPDB Length = 318 Score = 38.9 bits (89), Expect = 0.007, Method: Compositional matrix adjust. Identities = 31/131 (23%), Positives = 61/131 (46%), Gaps = 23/131 (17%) Query: 113 LIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD----- 167 L++ ++ + ++ +HRD+KP N + +G+ G VY + DFG A++ D Sbjct: 106 LLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVY-IIDFGLAKKYRDARTHQH 164 Query: 168 ---EQFVSLYGTEEYLHPDMY---ERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 + +L GT Y + + E++ R+D DL S+G + GSLP+ Sbjct: 165 IPYRENKNLTGTARYASINTHLGIEQS--RRD---------DLESLGYVLMYFNLGSLPW 213 Query: 222 RPFEGPRRNKE 232 + + + ++ Sbjct: 214 QGLKAATKRQK 224 >5A46-A nrPDB Length = 386 Score = 38.9 bits (89), Expect = 0.007, Method: Compositional matrix adjust. Identities = 46/205 (22%), Positives = 88/205 (42%), Gaps = 34/205 (16%) Query: 36 AIKVFNNISFLRPVDVQMREFEVLKKLN-HKNIVKLFAIEEETTTRHKVLIMEFCPCGSL 94 A+K+ + + + + + E E++K + HKNI+ L + + +I+E+ G+L Sbjct: 76 AVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLY--VIVEYASKGNL 133 Query: 95 YTVLE---EPSNAYG----------LPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNI 141 L+ P Y L + + V GM +L +HRD+ N+ Sbjct: 134 REYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNV 193 Query: 142 MRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTE---EYLHPD-MYERAVLRKDHQKK 197 + + ED +V K+ DFG AR++ + + +++ P+ +++R Sbjct: 194 L--VTED--NVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRI--------- 240 Query: 198 YGATVDLWSIGVTFYHAAT-GSLPF 221 Y D+WS GV + T G P+ Sbjct: 241 YTHQSDVWSFGVLLWEIFTLGGSPY 265 >4C59-A nrPDB Length = 340 Score = 38.9 bits (89), Expect = 0.008, Method: Compositional matrix adjust. Identities = 56/237 (23%), Positives = 96/237 (40%), Gaps = 47/237 (19%) Query: 14 ILGQGATANVFRGRHKKTGDLFAIK--VFNNISFLRPVDVQMREFEVLKKLN-HKNIVKL 70 +L +G A V+ + +G +A+K + N R + ++E +KKL+ H NIV+ Sbjct: 34 VLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRAI---IQEVCFMKKLSGHPNIVQF 90 Query: 71 FAI------EEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 124 + E +T +L+ E C G L L++ + L L + + Sbjct: 91 CSAASIGKEESDTGQAEFLLLTELCK-GQLVEFLKKMESRGPLSCDTVLKIFYQTCRAVQ 149 Query: 125 HL--RENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAA---------------RELEDD 167 H+ ++ I+HRD+K N++ Q KL DFG+A R L ++ Sbjct: 150 HMHRQKPPIIHRDLKVENLLL----SNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEE 205 Query: 168 E---QFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 E +Y T E + D+Y + G D+W++G Y PF Sbjct: 206 EITRNTTPMYRTPEII--DLYSNFPI--------GEKQDIWALGCILYLLCFRQHPF 252 >4XHH-A nrPDB Length = 403 Score = 38.9 bits (89), Expect = 0.008, Method: Compositional matrix adjust. Identities = 50/222 (22%), Positives = 99/222 (44%), Gaps = 36/222 (16%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 74 +G G+ +++ G + +G+ AI++ + S +D + R ++ L ++ F E Sbjct: 15 IGSGSFGDIYHGTNLISGEEVAIRLESIRSRHPQLDYESRVYKYLSGGVGIPFIRWFGRE 74 Query: 75 EETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLR---DVVGGMNHLRENGI 131 E + ++++ L LE+ N Y + F V+ ++ + ++ Sbjct: 75 GE----YNAMVIDL-----LGPSLEDLFN-YCHRKFSFKTVIMLALQMICRVQYIHGRSF 124 Query: 132 VHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELED--------DEQFVSLYGTEEYLHPD 183 +HRDIKP N + +G G +V+ + DFG +++ D + SL GT Y + Sbjct: 125 IHRDIKPDNFLMGVGRRGSTVH-VIDFGLSKKYRDFNTHRHIPYRENKSLTGTARYASVN 183 Query: 184 MY---ERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFR 222 + E++ R+D DL S+G + GSLP++ Sbjct: 184 THLGIEQS--RRD---------DLESLGYMLIYFCKGSLPWQ 214 >6FEX-A nrPDB Length = 321 Score = 38.9 bits (89), Expect = 0.008, Method: Compositional matrix adjust. Identities = 43/177 (24%), Positives = 71/177 (40%), Gaps = 35/177 (19%) Query: 53 MREFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLE----EPSNAYGLP 108 ++E +++ +L NI++L + + +I ++ G L L E A G P Sbjct: 78 LKEVKIMSRLKDPNIIRLLGVCVQDDP--LCMITDYMENGDLNQFLSAHQLEDKAAEGAP 135 Query: 109 ESE------FLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAAR 162 L V + GM +L VHRD+ N + +GE+ K+ DFG +R Sbjct: 136 GDPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCL--VGEN--FTIKIADFGMSR 191 Query: 163 ELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQK-------KYGATVDLWSIGVTFY 212 +LY + Y + RAVL K+ D+W+ GVT + Sbjct: 192 ---------NLYAGDYY---RVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLW 236 >2WO6-A nrPDB Length = 382 Score = 38.9 bits (89), Expect = 0.009, Method: Compositional matrix adjust. Identities = 46/215 (21%), Positives = 92/215 (42%), Gaps = 18/215 (8%) Query: 11 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNI-SFLRPVDVQMREFEVLKKLNHKNIVK 69 + ++G+G+ V + + + AIK+ N +FL +++R E++ K + + Sbjct: 58 IDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYY 117 Query: 70 LFAIEEETTTR-HKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR- 127 + ++ R H L+ E +LY +L +N G+ + + + + L Sbjct: 118 IVHLKRHFMFRNHLCLVFEMLSY-NLYDLLRN-TNFRGVSLNLTRKFAQQMCTALLFLAT 175 Query: 128 -ENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYE 186 E I+H D+KP NI+ + +S K+ DFG++ +L ++ + Y P++ Sbjct: 176 PELSIIHCDLKPENIL--LCNPKRSAIKIVDFGSSCQL--GQRIYQYIQSRFYRSPEVLL 231 Query: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 Y +D+WS+G TG F Sbjct: 232 GM--------PYDLAIDMWSLGCILVEMHTGEPLF 258 >3HNG-A nrPDB Length = 360 Score = 38.5 bits (88), Expect = 0.010, Method: Compositional matrix adjust. Identities = 32/125 (25%), Positives = 56/125 (44%), Gaps = 17/125 (13%) Query: 119 VVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTE- 177 V GM L +HRD+ NI+ + E+ +V K+ DFG AR++ + +V T Sbjct: 208 VARGMEFLSSRKCIHRDLAARNIL--LSEN--NVVKICDFGLARDIYKNPDYVRKGDTRL 263 Query: 178 --EYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMY 235 +++ P+ K Y D+WS GV + SL P+ G + +++ Sbjct: 264 PLKWMAPESI--------FDKIYSTKSDVWSYGVLLWEIF--SLGGSPYPGVQMDEDFCS 313 Query: 236 KIITG 240 ++ G Sbjct: 314 RLREG 318 >4MD7-E nrPDB Length = 391 Score = 38.1 bits (87), Expect = 0.013, Method: Compositional matrix adjust. Identities = 31/143 (21%), Positives = 66/143 (46%), Gaps = 16/143 (11%) Query: 66 NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 125 NI+ L I ++ +R L+ E + + L + + + +++ +++ Sbjct: 93 NIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT------LTDYDIRFYMYEILKALDY 146 Query: 126 LRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMY 185 GI+HRD+KP N+M I + + + +L D+G A +++ + + P+ Sbjct: 147 CHSMGIMHRDVKPHNVM--IDHEHRKL-RLIDWGLAEFYHPGQEYNVRVASRYFKGPE-- 201 Query: 186 ERAVLRKDHQKKYGATVDLWSIG 208 L D+Q Y ++D+WS+G Sbjct: 202 ----LLVDYQ-MYDYSLDMWSLG 219 >4XHL-A nrPDB Length = 394 Score = 37.4 bits (85), Expect = 0.027, Method: Compositional matrix adjust. Identities = 30/111 (27%), Positives = 52/111 (46%), Gaps = 23/111 (20%) Query: 123 MNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELED--------DEQFVSLY 174 + ++ +HRDIKP N + +G G +V+ + DFG +++ D + SL Sbjct: 116 IQYIHGRSFIHRDIKPDNFLMGVGRRGSTVH-VIDFGLSKKYRDFNTHRHIPYRENKSLT 174 Query: 175 GTEEYLHPDMY---ERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFR 222 GT Y + + E++ R+D DL S+G + GSLP++ Sbjct: 175 GTARYASVNTHLGIEQS--RRD---------DLESLGYVLIYFCKGSLPWQ 214 >3ZBF-A nrPDB Length = 322 Score = 37.0 bits (84), Expect = 0.034, Method: Compositional matrix adjust. Identities = 55/238 (23%), Positives = 99/238 (41%), Gaps = 21/238 (8%) Query: 14 ILGQGATANVFRGRHKK-----TGDL-FAIKVFNNISFLRPVDVQMREFEVLKKLNHKNI 67 +LG GA V+ G +G++ A+K S + ++E ++ K NH NI Sbjct: 40 LLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNI 99 Query: 68 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNA--YG--LPESEFLIVLRDVVGGM 123 +K + + +I+E G L T L + A YG L + + + D+ G Sbjct: 100 LKQLGV--CLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGC 157 Query: 124 NHLRENGIVHRDIKPGNIMRVIGE-DGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHP 182 +L +HRD+ N + + + + K+ DFG AR++ ++ + E L P Sbjct: 158 VYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRK---RGEGLLP 214 Query: 183 DMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITG 240 + D + D+WS G+ + T L +P+ N +V+ + TG Sbjct: 215 VRWMAPESLMD--GIFTTQSDVWSFGILIWEILT--LGHQPYPA-HSNLDVLNYVQTG 267 >4JRN-A nrPDB Length = 372 Score = 36.6 bits (83), Expect = 0.039, Method: Compositional matrix adjust. Identities = 32/109 (29%), Positives = 49/109 (44%), Gaps = 17/109 (15%) Query: 109 ESEFLIVLR-----DVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARE 163 +SEF +V+R + + +++ GIVH DIKP N + + +DG+ L DFG R Sbjct: 196 KSEFGLVVRMYLSSQAIKLVANVQAQGIVHTDIKPANFLLL--KDGRLF--LGDFGTYR- 250 Query: 164 LEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFY 212 + GT Y P+ +A Y D W +G+T Y Sbjct: 251 --INNSVGRAIGTPGYEPPERPFQAT-----GITYTFPTDAWQLGITLY 292 >2H34-A nrPDB Length = 309 Score = 36.6 bits (83), Expect = 0.042, Method: Compositional matrix adjust. Identities = 28/92 (30%), Positives = 44/92 (47%), Gaps = 14/92 (15%) Query: 133 HRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDE--QFVSLYGTEEYLHPDMYERAVL 190 HRD+KP NI+ V +D L DFG A D++ Q + GT Y+ P+ + Sbjct: 157 HRDVKPENIL-VSADD---FAYLVDFGIASATTDEKLTQLGNTVGTLYYMAPERF----- 207 Query: 191 RKDHQKKYGATVDLWSIGVTFYHAATGSLPFR 222 + Y A D++++ Y TGS P++ Sbjct: 208 -SESHATYRA--DIYALTCVLYECLTGSPPYQ 236 >4CI6-B nrPDB Length = 643 Score = 35.4 bits (80), Expect = 0.085, Method: Compositional matrix adjust. Identities = 16/26 (61%), Positives = 19/26 (73%), Gaps = 2/26 (7%) Query: 124 NHLRENGIVHRDIKPGNIM--RVIGE 147 NHL + GIVH DIKPGN++ R GE Sbjct: 170 NHLAKAGIVHNDIKPGNVVFDRASGE 195 >6BSD-A nrPDB Length = 876 Score = 35.4 bits (80), Expect = 0.098, Method: Compositional matrix adjust. Identities = 46/202 (22%), Positives = 78/202 (38%), Gaps = 41/202 (20%) Query: 34 LFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGS 93 L A+K+ + + ++E +++ +L NI++L + + +I ++ G Sbjct: 614 LVAVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDP--LCMITDYMENGD 671 Query: 94 LYTVLE----EPSNAYGLPESE------------FLIVLRDVVGGMNHLRENGIVHRDIK 137 L L E A G P L V + GM +L VHRD+ Sbjct: 672 LNQFLSAHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLA 731 Query: 138 PGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQK- 196 N + +GE+ K+ DFG +R +LY + Y + RAVL Sbjct: 732 TRNCL--VGEN--FTIKIADFGMSR---------NLYAGDYY---RVQGRAVLPIRWMAW 775 Query: 197 ------KYGATVDLWSIGVTFY 212 K+ D+W+ GVT + Sbjct: 776 ECILMGKFTTASDVWAFGVTLW 797 >5E8V-A nrPDB Length = 316 Score = 35.4 bits (80), Expect = 0.10, Method: Compositional matrix adjust. Identities = 50/201 (24%), Positives = 84/201 (41%), Gaps = 34/201 (16%) Query: 11 LSDILGQGATANVFRGRHKK-TGDLF---AIKVFNNISFLRPVDVQMREFEVLKKLN--H 64 L ++G+G A V++ + K+ T + F A+K+F + E ++ +N H Sbjct: 13 LDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYAS----WKTEKDIFSDINLKH 68 Query: 65 KNIVKLFAIEEETTTRHK--VLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGG 122 +NI++ EE T K LI F G+L L + + + + + G Sbjct: 69 ENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYL----TRHVISWEDLRKLGSSLARG 124 Query: 123 MNHLREN---------GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELE-----DDE 168 + HL + IVHRD+K NI+ + D L DFG + L+ DD Sbjct: 125 IAHLHSDHTPCGRPKMPIVHRDLKSSNIL--VKNDLTCC--LCDFGLSLRLDPTLSVDDL 180 Query: 169 QFVSLYGTEEYLHPDMYERAV 189 GT Y+ P++ A+ Sbjct: 181 ANSGQVGTARYMAPEVLASAM 201 >5FQD-C nrPDB Length = 341 Score = 35.0 bits (79), Expect = 0.10, Method: Compositional matrix adjust. Identities = 16/55 (29%), Positives = 30/55 (54%), Gaps = 1/55 (1%) Query: 113 LIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD 167 L++ ++ + ++ +HRDIKP N + IG ++ L DFG A++ D+ Sbjct: 118 LMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLF-LIDFGLAKKYRDN 171 >6EAS-A nrPDB Length = 308 Score = 33.5 bits (75), Expect = 0.31, Method: Compositional matrix adjust. Identities = 44/176 (25%), Positives = 73/176 (41%), Gaps = 30/176 (17%) Query: 59 LKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRD 118 L K++HKN + L EE +V++ E+ P G+L+ L + + +++ LR Sbjct: 95 LSKVSHKNFMNLLGYCEEEHPFTRVMVFEYAPNGTLFEHL----HVREAEKLDWMARLR- 149 Query: 119 VVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGA-ARELE---DDEQFVSLY 174 + G+ + E+ +H+ P + D +VY DF A +LE D + S Sbjct: 150 ISMGIAYCLEH--MHQLQTPAALRNF---DSTTVYLTDDFAAKVSDLEFWNDAKGHNSTT 204 Query: 175 GTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRN 230 E PDM +D +KY G+ TG +P +GP N Sbjct: 205 NNELAFSPDM-------EDIVRKY---------GMVLLEILTGRVPSSEDDGPLEN 244 >2X7G-A nrPDB Length = 389 Score = 33.1 bits (74), Expect = 0.45, Method: Compositional matrix adjust. Identities = 17/47 (36%), Positives = 27/47 (57%), Gaps = 1/47 (2%) Query: 102 SNAYGLPESEFLIVLRDVVGGMNHLRENG-IVHRDIKPGNIMRVIGE 147 SN GLP ++R V+ G+++L I+H DIKP NI+ + + Sbjct: 132 SNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDD 178 >4NT4-A nrPDB Length = 312 Score = 32.7 bits (73), Expect = 0.51, Method: Compositional matrix adjust. Identities = 30/122 (24%), Positives = 58/122 (47%), Gaps = 23/122 (18%) Query: 113 LIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDG---QSVYKLTDFGAARELEDDE- 168 L++ + ++ + ++ +++RD+KP N + IG + + + DFG A+E D + Sbjct: 117 LMIAKQLLHRIEYVHSRHLIYRDVKPENFL--IGRTSTKREKIIHIIDFGLAKEYIDLDT 174 Query: 169 -------QFVSLYGTEEYLHPDMY-ERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLP 220 + SL GT Y+ + + R R+D DL ++G F + GSLP Sbjct: 175 NRHIPYREHKSLTGTARYMSINTHMGREQSRRD---------DLEALGHMFMYFLRGSLP 225 Query: 221 FR 222 ++ Sbjct: 226 WQ 227 >6J6I-B nrPDB Length = 351 Score = 32.3 bits (72), Expect = 0.74, Method: Compositional matrix adjust. Identities = 55/232 (23%), Positives = 94/232 (40%), Gaps = 40/232 (17%) Query: 63 NHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYT---VLEEPSNAYGLPESEFLIVLRDV 119 NH N ++L E VL+ EF G++ V+ + LP S L + +++ Sbjct: 116 NHSNFLQLLGCCLEFP--FPVLVFEFAEHGAMNQRGGVIVNGEESL-LPWSVRLKIGKEI 172 Query: 120 VGGMNHLR---ENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVS---L 173 + +L I+HRD+KP ++ D KL+D + L + + + + Sbjct: 173 ANAVTYLHTAFPKIIIHRDVKPMHVFL----DKNWTAKLSDLSFSISLPEGKSRIEAEWV 228 Query: 174 YGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEV 233 GT Y+ P +Y + ++ D++S G+ TG K Sbjct: 229 LGTFGYIDP-LYHKTCFVTEY-------TDVYSFGICLLVIITG-------------KPA 267 Query: 234 MYKIITGKPSGAISGVQK-AENGPIDWSGDMPVSCSLSRG--LQVLLTPVLA 282 + I G G +S V++ ENG +D D + ++ G LQV VLA Sbjct: 268 IMTISDGDLQGILSLVRELCENGKLDEVIDPRLMKDITSGQRLQVEACVVLA 319 >5VE6-A nrPDB Length = 492 Score = 32.3 bits (72), Expect = 0.74, Method: Compositional matrix adjust. Identities = 13/36 (36%), Positives = 22/36 (61%) Query: 109 ESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRV 144 E +L + G+ HL+E+GI+HRD+ N++ V Sbjct: 207 ERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLV 242 >6EWX-A nrPDB Length = 484 Score = 32.3 bits (72), Expect = 0.79, Method: Compositional matrix adjust. Identities = 13/36 (36%), Positives = 22/36 (61%) Query: 109 ESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRV 144 E +L + G+ HL+E+GI+HRD+ N++ V Sbjct: 209 ERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLV 244 >1MPY-A nrPDB Length = 307 Score = 32.0 bits (71), Expect = 1.0, Method: Compositional matrix adjust. Identities = 46/184 (25%), Positives = 78/184 (42%), Gaps = 19/184 (10%) Query: 42 NISFLRPVDVQMREFEVLKKLNHKNIVKLFA-IEEETTTRHKVLIMEFCPCGSLYTVLEE 100 N +RP VQ+R ++ K L H V+L IE + + +V + + VL E Sbjct: 2 NKGVMRPGHVQLRVLDMSKALEH--YVELLGLIEMDRDDQGRVYLKAWTEVDKFSLVLRE 59 Query: 101 PSNAYGLPESEFLIVLRDVVGGMNH-LRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFG 159 ++ G+ F +V D + + L G + G + G+ V G Sbjct: 60 -ADEPGMDFMGFKVVDEDALRQLERDLMAYGCAVEQLPAGELNSC----GRRVRFQAPSG 114 Query: 160 AARELEDDEQFVSLYGTEEYLHPDMYER-----AVLRKDHQKKYG----ATVDLWSIGVT 210 EL D+++ +G + ++P+ + R A +R DH YG AT DL++ + Sbjct: 115 HHFELYADKEYTGKWGLND-VNPEAWPRDLKGMAAVRFDHALMYGDELPATYDLFTKVLG 173 Query: 211 FYHA 214 FY A Sbjct: 174 FYLA 177 >1CSN-A nrPDB Length = 298 Score = 32.0 bits (71), Expect = 1.1, Method: Compositional matrix adjust. Identities = 30/120 (25%), Positives = 56/120 (46%), Gaps = 21/120 (17%) Query: 114 IVLRDVVGGMNHLRENGIVHRDIKPGNIM--RVIGEDGQSVYKLTDFGAARELEDD--EQ 169 + + ++ + + E +V+RDIKP N + R ++ +Y + DFG + D +Q Sbjct: 110 MAAKQMLARVQSIHEKSLVYRDIKPDNFLIGRPNSKNANMIY-VVDFGMVKFYRDPVTKQ 168 Query: 170 FV------SLYGTEEYLHPDMY-ERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFR 222 + +L GT Y+ + + R R+D DL ++G F + GSLP++ Sbjct: 169 HIPYREKKNLSGTARYMSINTHLGREQSRRD---------DLEALGHVFMYFLRGSLPWQ 219 >6DC0-A nrPDB Length = 292 Score = 31.6 bits (70), Expect = 1.2, Method: Compositional matrix adjust. Identities = 25/116 (21%), Positives = 46/116 (39%), Gaps = 9/116 (7%) Query: 107 LPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELE- 165 L E E + + +V + H ++ IV D+K V + ++ +L ++ Sbjct: 94 LREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKF--VFSTEERTQLRLESLEDTHIMKG 151 Query: 166 DDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 +D+ +G Y+ P++ G D+WS+GV Y G PF Sbjct: 152 EDDALSDKHGCPAYVSPEILNTT------GTYSGKAADVWSLGVMLYTLLVGRYPF 201 >5CEK-A nrPDB Length = 263 Score = 31.2 bits (69), Expect = 1.5, Method: Compositional matrix adjust. Identities = 25/116 (21%), Positives = 46/116 (39%), Gaps = 9/116 (7%) Query: 107 LPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELE- 165 L E E + + +V + H ++ IV D+K V + ++ +L ++ Sbjct: 97 LREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKF--VFSTEERTQLRLESLEDTHIMKG 154 Query: 166 DDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 +D+ +G Y+ P++ G D+WS+GV Y G PF Sbjct: 155 EDDALSDKHGCPAYVSPEILNTT------GTYSGKAADVWSLGVMLYTLLVGRYPF 204 >4WUA-A nrPDB Length = 401 Score = 31.2 bits (69), Expect = 1.7, Method: Compositional matrix adjust. Identities = 17/47 (36%), Positives = 27/47 (57%), Gaps = 1/47 (2%) Query: 102 SNAYGLPESEFLIVLRDVVGGMNHLRENG-IVHRDIKPGNIMRVIGE 147 SN GLP +++ V+ G+++L I+H DIKP NI+ + E Sbjct: 142 SNYQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNE 188 >5LVV-A nrPDB Length = 749 Score = 30.8 bits (68), Expect = 2.2, Method: Compositional matrix adjust. Identities = 20/87 (22%), Positives = 41/87 (47%), Gaps = 9/87 (10%) Query: 474 NIEKTVKVYEKLMKINLEAAELGEISDIHTKLLRLSSSQGTIETSLQDIDSRLSPGGSLA 533 NIE+ V++Y K +++ E + H+ L + QG ++ +L + + A Sbjct: 45 NIEEAVRLYRKALEV------FPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFA 98 Query: 534 DAWAHQEGTHPKDRNVEKLQVLLNCMT 560 DA+++ T + ++ +Q L C T Sbjct: 99 DAYSNMGNTL---KEMQDVQGALQCYT 122 >6EQI-C nrPDB Length = 433 Score = 30.4 bits (67), Expect = 2.7, Method: Compositional matrix adjust. Identities = 29/107 (27%), Positives = 43/107 (40%), Gaps = 14/107 (13%) Query: 125 HLRENGIVHRDIKPGNIMRVIGE-DGQSVYKLTDFGAARELEDDEQ-FVSLYGTEEYLHP 182 H+ + I HRD+K NI+ + E D +TDFG L D + V Y +E+ Sbjct: 182 HMNIHNISHRDLKSDNILVDLSEGDAYPTIVITDFGCC--LCDKQNGLVIPYRSED--QD 237 Query: 183 DMYERAVLRKDHQKKYGATV--------DLWSIGVTFYHAATGSLPF 221 RA++ + T DLW++G Y PF Sbjct: 238 KGGNRALMAPEIANAKPGTFSWLNYKKSDLWAVGAIAYEIFNIDNPF 284 >6J2C-O nrPDB Length = 393 Score = 30.4 bits (67), Expect = 2.8, Method: Compositional matrix adjust. Identities = 21/83 (25%), Positives = 43/83 (51%), Gaps = 7/83 (8%) Query: 580 EQIHKFDKQKLYYHATKAMTHFTDEC------VKKYEAFLNKSEEWIRKMLHLRKQLLSL 633 EQ KF ++KL++ ++++T F D+ ++ Y+ F++K + I + L + K LL+ Sbjct: 27 EQFEKFYEEKLWFQLSESLTKFFDDAKSTPLRLRLYDNFVSKFYDKINQ-LSVVKYLLAS 85 Query: 634 TNQCFDIEEEVSKYQEYTNELQE 656 D +E + + + QE Sbjct: 86 LKDSKDFDESLKYLDDLKAQFQE 108 >1W3B-A nrPDB Length = 388 Score = 29.6 bits (65), Expect = 4.7, Method: Compositional matrix adjust. Identities = 16/69 (23%), Positives = 33/69 (47%), Gaps = 6/69 (8%) Query: 474 NIEKTVKVYEKLMKINLEAAELGEISDIHTKLLRLSSSQGTIETSLQDIDSRLSPGGSLA 533 NIE+ V++Y K +++ E + H+ L + QG ++ +L + + A Sbjct: 320 NIEEAVRLYRKALEV------FPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFA 373 Query: 534 DAWAHQEGT 542 DA+++ T Sbjct: 374 DAYSNMGNT 382 >3OP7-A nrPDB Length = 375 Score = 28.9 bits (63), Expect = 7.9, Method: Compositional matrix adjust. Identities = 21/76 (27%), Positives = 33/76 (43%), Gaps = 16/76 (21%) Query: 132 VHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLR 191 ++ +KP I++ G G ++ L +E + +SLY T + L+ Sbjct: 75 LYTGVKPEQILQTNGATGANLLVLYSL-----IEPGDHVISLYPTYQQLY---------- 119 Query: 192 KDHQKKYGATVDLWSI 207 D K GA VDLW I Sbjct: 120 -DIPKSLGAEVDLWQI 134 >4QX0-A nrPDB Length = 587 Score = 28.9 bits (63), Expect = 8.5, Method: Compositional matrix adjust. Identities = 19/63 (30%), Positives = 30/63 (47%), Gaps = 10/63 (15%) Query: 576 AYNEEQIHKFDKQKLYYHATKAMTHFTDECVKKYEAFLNK-----SEEWIRKMLHLRKQL 630 Y +E I +F K++L K +TD CVK Y L+K E W+ + R+ Sbjct: 162 GYEKEDIAEFYKRQL-----KLTQEYTDHCVKWYNVGLDKLRGSSYESWVNFNRYRREMT 216 Query: 631 LSL 633 L++ Sbjct: 217 LTV 219 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 6NT9-A nrPDB 1253 0.0 6O8B-A nrPDB 1106 0.0 4JLC-A nrPDB 1086 0.0 4EUT-A nrPDB 563 e-160 4EUU-A nrPDB 435 e-122 4KIK-B nrPDB 327 1e-89 5TQX-A nrPDB 306 2e-83 3QA8-A nrPDB 285 6e-77 3NCG-A nrPDB 254 1e-67 3DFA-A nrPDB 244 7e-65 6FDY-U nrPDB 241 1e-63 4MVF-A nrPDB 239 2e-63 3LIJ-A nrPDB 237 9e-63 2HAK-A nrPDB 237 9e-63 5ES1-A nrPDB 236 2e-62 3DXN-A nrPDB 236 3e-62 6C9D-A nrPDB 236 3e-62 2QNJ-A nrPDB 236 4e-62 5JN2-A nrPDB 234 7e-62 5KZ7-A nrPDB 234 9e-62 3HZT-A nrPDB 234 1e-61 3Q5I-A nrPDB 233 3e-61 3MA6-A nrPDB 232 5e-61 4WNO-A nrPDB 231 8e-61 6QAU-A nrPDB 231 9e-61 5XZW-A nrPDB 231 1e-60 4CFF-A nrPDB 231 1e-60 4REW-A nrPDB 230 2e-60 5EZV-A nrPDB 229 3e-60 4RED-A nrPDB 229 5e-60 2JC6-A nrPDB 229 5e-60 2YZA-A nrPDB 228 9e-60 2BDW-A nrPDB 227 1e-59 4CFH-A nrPDB 227 1e-59 3F3Z-A nrPDB 227 1e-59 4RGJ-A nrPDB 227 2e-59 3KK8-A nrPDB 227 2e-59 5IG1-A nrPDB 226 2e-59 3IS5-A nrPDB 226 3e-59 2J90-A nrPDB 226 4e-59 5JZN-A nrPDB 225 7e-59 5FG8-A nrPDB 224 8e-59 4FG9-A nrPDB 224 1e-58 4CSV-A nrPDB 223 2e-58 2JAM-A nrPDB 222 3e-58 3MN3-A nrPDB 221 9e-58 4PDS-A nrPDB 221 9e-58 4D28-A nrPDB 221 1e-57 4CZT-A nrPDB 220 1e-57 2YCR-A nrPDB 219 2e-57 3H4J-B nrPDB 219 3e-57 3UC3-A nrPDB 219 3e-57 4YZB-A nrPDB 219 4e-57 2BPM-A nrPDB 219 5e-57 3I6U-A nrPDB 218 6e-57 2VN9-A nrPDB 218 7e-57 6E9W-A nrPDB 218 7e-57 6HXF-B nrPDB 218 8e-57 2Z7Q-A nrPDB 217 1e-56 5YKS-A nrPDB 217 1e-56 3TAC-A nrPDB 217 1e-56 2W4O-A nrPDB 217 2e-56 2YAB-A nrPDB 216 2e-56 3HDN-A nrPDB 216 2e-56 3NIZ-A nrPDB 216 2e-56 5WAX-A nrPDB 216 3e-56 3TXO-A nrPDB 216 4e-56 4GS6-A nrPDB 216 4e-56 1FOT-A nrPDB 215 5e-56 6ED6-A nrPDB 215 6e-56 2VZ6-A nrPDB 215 7e-56 5U6Y-A nrPDB 214 8e-56 5D9K-A nrPDB 214 9e-56 3GUB-A nrPDB 214 1e-55 4UY9-A nrPDB 214 1e-55 3DTC-A nrPDB 214 2e-55 2UV2-A nrPDB 213 2e-55 1PHK-A nrPDB 213 2e-55 2A27-A nrPDB 213 3e-55 4KRC-A nrPDB 212 3e-55 1ZWS-A nrPDB 212 4e-55 6GU6-A nrPDB 212 5e-55 3GC9-A nrPDB 212 6e-55 3ZUT-A nrPDB 212 6e-55 4QMW-A nrPDB 211 6e-55 2V7O-A nrPDB 211 8e-55 4WB7-A nrPDB 211 1e-54 5X3F-B nrPDB 211 1e-54 4RA4-A nrPDB 211 1e-54 5N23-A nrPDB 211 1e-54 2JDO-A nrPDB 210 2e-54 4NIF-A nrPDB 210 2e-54 3UDB-A nrPDB 210 2e-54 3PPZ-A nrPDB 210 2e-54 4JG6-A nrPDB 210 2e-54 3BHH-A nrPDB 209 3e-54 4YNZ-A nrPDB 209 3e-54 4D2V-A nrPDB 209 5e-54 2Y7J-A nrPDB 208 6e-54 2X4F-A nrPDB 208 6e-54 3COM-A nrPDB 208 7e-54 4JXF-A nrPDB 208 7e-54 4EWQ-A nrPDB 208 7e-54 3DAK-A nrPDB 208 8e-54 4IC8-A nrPDB 208 9e-54 5Z33-A nrPDB 208 9e-54 4RLP-A nrPDB 207 1e-53 3KN6-A nrPDB 207 1e-53 2XIK-A nrPDB 207 1e-53 4L42-A nrPDB 207 1e-53 4UYA-A nrPDB 207 1e-53 5X8I-B nrPDB 207 2e-53 3MV5-A nrPDB 207 2e-53 1UA2-A nrPDB 207 2e-53 4H1J-A nrPDB 207 2e-53 5KCV-A nrPDB 207 2e-53 4CQG-A nrPDB 207 2e-53 4B6L-A nrPDB 206 2e-53 3ZDU-A nrPDB 206 2e-53 3SOA-A nrPDB 206 2e-53 1CM8-A nrPDB 206 2e-53 5F9E-A nrPDB 206 3e-53 1VZO-A nrPDB 205 4e-53 4BGQ-A nrPDB 205 5e-53 5AIR-A nrPDB 205 6e-53 6DTL-A nrPDB 205 6e-53 4AT3-A nrPDB 205 6e-53 6E2O-A nrPDB 205 7e-53 4ZSG-A nrPDB 205 7e-53 3OHT-A nrPDB 204 9e-53 5DBX-A nrPDB 204 1e-52 3TKU-A nrPDB 204 1e-52 6BDL-A nrPDB 204 1e-52 3PFQ-A nrPDB 204 1e-52 6NPU-A nrPDB 204 1e-52 4BBM-A nrPDB 204 1e-52 5D7A-A nrPDB 204 1e-52 4P5Q-A nrPDB 204 1e-52 4UZD-A nrPDB 204 1e-52 6FD3-A nrPDB 204 2e-52 5MJB-A nrPDB 203 2e-52 6CMJ-A nrPDB 203 2e-52 2I0E-A nrPDB 203 3e-52 4XEY-B nrPDB 203 3e-52 5L6P-A nrPDB 203 3e-52 2XYN-A nrPDB 203 3e-52 2FO0-A nrPDB 203 3e-52 2BRG-A nrPDB 203 3e-52 4FZF-B nrPDB 202 3e-52 4AW2-A nrPDB 202 3e-52 3DB8-A nrPDB 202 4e-52 2Y6O-A nrPDB 202 5e-52 2R2P-A nrPDB 202 5e-52 2F9G-A nrPDB 202 5e-52 4AGU-A nrPDB 201 7e-52 5DYK-A nrPDB 201 8e-52 5FET-A nrPDB 201 8e-52 1JPA-A nrPDB 201 8e-52 4EBW-A nrPDB 201 9e-52 4AU8-A nrPDB 200 1e-51 2F57-A nrPDB 200 2e-51 5AWM-A nrPDB 200 2e-51 4APC-A nrPDB 200 2e-51 2XNP-A nrPDB 200 2e-51 4LG4-A nrPDB 200 2e-51 4YFF-A nrPDB 200 2e-51 5NGU-A nrPDB 199 3e-51 3QGY-A nrPDB 199 3e-51 6FYV-A nrPDB 199 3e-51 3V5Q-A nrPDB 199 4e-51 3DKO-A nrPDB 199 4e-51 5VO2-A nrPDB 199 4e-51 3Q53-A nrPDB 199 5e-51 3A8W-A nrPDB 198 6e-51 3D2K-A nrPDB 198 6e-51 2VWV-A nrPDB 198 8e-51 6AO5-A nrPDB 198 9e-51 2J0K-A nrPDB 198 9e-51 2OGV-A nrPDB 197 1e-50 5YV8-A nrPDB 197 1e-50 1V0B-A nrPDB 197 1e-50 1KOB-A nrPDB 197 1e-50 4I6B-A nrPDB 197 2e-50 6GQK-A nrPDB 197 2e-50 4U41-A nrPDB 197 2e-50 2H8H-A nrPDB 196 2e-50 6CQF-A nrPDB 196 2e-50 3BEA-A nrPDB 196 3e-50 3KUL-B nrPDB 196 3e-50 4MYG-A nrPDB 196 3e-50 4TNB-A nrPDB 196 3e-50 4QTB-A nrPDB 196 4e-50 4E93-A nrPDB 195 4e-50 4E7W-A nrPDB 195 4e-50 5EFQ-A nrPDB 195 5e-50 5GRN-A nrPDB 195 5e-50 3UTO-A nrPDB 195 5e-50 3NYO-A nrPDB 195 6e-50 1LUF-A nrPDB 195 7e-50 3OZ6-A nrPDB 195 8e-50 4FR4-A nrPDB 194 8e-50 2WQN-A nrPDB 194 9e-50 2DQ7-X nrPDB 194 9e-50 6DBM-A nrPDB 194 1e-49 4PDO-A nrPDB 194 1e-49 3FXW-A nrPDB 194 1e-49 3KRL-A nrPDB 194 1e-49 4OLI-A nrPDB 194 1e-49 1G3N-A nrPDB 194 2e-49 1NY3-A nrPDB 194 2e-49 2OZA-A nrPDB 193 2e-49 1U59-A nrPDB 193 2e-49 3BBT-B nrPDB 193 2e-49 1KOA-A nrPDB 193 2e-49 6F3F-A nrPDB 193 2e-49 3KA0-A nrPDB 193 3e-49 3SXS-A nrPDB 193 3e-49 3ORZ-A nrPDB 193 3e-49 3HKO-A nrPDB 193 3e-49 5G6V-A nrPDB 192 3e-49 2OZO-A nrPDB 192 3e-49 2OU7-A nrPDB 192 3e-49 4KS7-A nrPDB 192 4e-49 5AMN-A nrPDB 192 4e-49 2W1I-A nrPDB 192 4e-49 2VD5-A nrPDB 192 4e-49 3IO7-A nrPDB 192 4e-49 4R7H-A nrPDB 192 5e-49 5H2U-A nrPDB 192 6e-49 4NST-A nrPDB 192 6e-49 4E20-A nrPDB 191 7e-49 4AF3-A nrPDB 191 7e-49 4FIE-A nrPDB 191 7e-49 5KMM-A nrPDB 191 8e-49 5X5O-A nrPDB 191 9e-49 4J52-A nrPDB 191 9e-49 5J5T-A nrPDB 191 9e-49 2PL0-A nrPDB 191 9e-49 2W96-B nrPDB 191 9e-49 4QNY-A nrPDB 191 9e-49 3CJF-A nrPDB 191 9e-49 4JDH-A nrPDB 191 1e-48 4B8L-A nrPDB 190 1e-48 5HI2-A nrPDB 190 1e-48 2HW6-A nrPDB 190 2e-48 3GC0-A nrPDB 190 2e-48 4XBR-A nrPDB 190 2e-48 2Q0N-A nrPDB 190 2e-48 5SYS-A nrPDB 190 2e-48 5U6C-A nrPDB 190 2e-48 3C51-A nrPDB 190 2e-48 3G0E-A nrPDB 190 2e-48 3OMV-A nrPDB 190 2e-48 3E7O-A nrPDB 190 3e-48 3RAW-A nrPDB 190 3e-48 6BXI-A nrPDB 189 3e-48 3PLS-A nrPDB 189 3e-48 4XUF-A nrPDB 189 3e-48 4HZS-A nrPDB 189 4e-48 5ZTN-A nrPDB 189 4e-48 3A4O-X nrPDB 189 4e-48 3QUP-A nrPDB 189 5e-48 4PWN-A nrPDB 188 6e-48 5HIE-A nrPDB 188 7e-48 6DBN-A nrPDB 188 7e-48 2HK5-A nrPDB 188 8e-48 5U6B-A nrPDB 188 8e-48 4HVI-A nrPDB 188 1e-47 4YHJ-A nrPDB 187 1e-47 5X02-A nrPDB 187 1e-47 5LOH-A nrPDB 187 1e-47 4XCU-A nrPDB 187 1e-47 5FM2-A nrPDB 187 1e-47 3EB0-A nrPDB 187 1e-47 4XLV-A nrPDB 187 1e-47 5Y86-A nrPDB 187 1e-47 3I81-A nrPDB 187 2e-47 5UUU-A nrPDB 186 2e-47 2XS0-A nrPDB 186 3e-47 3ORP-A nrPDB 186 3e-47 3PP0-A nrPDB 185 5e-47 1U5R-A nrPDB 185 6e-47 3PVW-A nrPDB 185 6e-47 6CKI-A nrPDB 185 7e-47 4O2Z-A nrPDB 184 9e-47 5GNK-A nrPDB 184 1e-46 4F0G-A nrPDB 184 1e-46 6E4F-A nrPDB 184 1e-46 1JNK-A nrPDB 184 1e-46 2GCD-A nrPDB 184 1e-46 5O2B-A nrPDB 184 1e-46 4XI2-A nrPDB 184 1e-46 5HLW-A nrPDB 184 1e-46 4OTD-A nrPDB 184 2e-46 5O2C-A nrPDB 183 2e-46 4Y93-A nrPDB 183 2e-46 4K33-A nrPDB 183 2e-46 3LZB-A nrPDB 183 3e-46 3FI2-A nrPDB 183 3e-46 3PG1-A nrPDB 183 3e-46 1FVR-A nrPDB 182 4e-46 3AOX-A nrPDB 182 4e-46 1U54-B nrPDB 182 6e-46 3ALO-A nrPDB 182 6e-46 3MIA-A nrPDB 182 6e-46 3E3P-A nrPDB 181 8e-46 1BYG-A nrPDB 180 1e-45 5UNP-A nrPDB 180 2e-45 3C1X-A nrPDB 180 2e-45 4C0T-A nrPDB 179 4e-45 1AD5-A nrPDB 179 4e-45 3LM0-A nrPDB 179 6e-45 2I6L-A nrPDB 178 7e-45 4LRM-A nrPDB 178 1e-44 1K9A-A nrPDB 177 1e-44 4CRS-A nrPDB 177 1e-44 5HVK-A nrPDB 177 2e-44 5B2L-A nrPDB 177 2e-44 6CCF-A nrPDB 176 3e-44 2WTK-C nrPDB 175 4e-44 4AN9-A nrPDB 175 5e-44 5UIU-A nrPDB 175 5e-44 6FER-A nrPDB 175 6e-44 4M7I-A nrPDB 175 7e-44 5LPV-A nrPDB 175 7e-44 5LPZ-A nrPDB 175 8e-44 5KKR-C nrPDB 174 1e-43 1S9I-A nrPDB 174 2e-43 4TPT-A nrPDB 174 2e-43 3EQC-A nrPDB 173 3e-43 4EQM-A nrPDB 173 3e-43 1ZXE-A nrPDB 172 6e-43 3N9X-A nrPDB 171 8e-43 3DLS-A nrPDB 170 2e-42 4X7Q-B nrPDB 170 2e-42 2A1A-B nrPDB 170 3e-42 3VN9-A nrPDB 169 3e-42 1TKI-A nrPDB 169 4e-42 3FME-A nrPDB 169 4e-42 5O0Y-A nrPDB 169 6e-42 3NIE-A nrPDB 168 7e-42 6CTH-A nrPDB 168 8e-42 4FL3-A nrPDB 168 8e-42 5XD6-A nrPDB 168 8e-42 6O6Q-A nrPDB 167 1e-41 5TOS-A nrPDB 167 1e-41 4IDT-A nrPDB 167 2e-41 6B2Q-A nrPDB 166 3e-41 4X3F-A nrPDB 166 3e-41 4OW8-A nrPDB 166 3e-41 3RP9-A nrPDB 165 5e-41 4G3E-A nrPDB 165 6e-41 3ZZW-A nrPDB 165 7e-41 5C26-A nrPDB 165 8e-41 3UIU-A nrPDB 165 9e-41 3M42-A nrPDB 164 2e-40 5WNO-A nrPDB 163 2e-40 6GVJ-A nrPDB 163 3e-40 5USZ-A nrPDB 162 5e-40 4CRL-A nrPDB 162 6e-40 3LMG-A nrPDB 161 1e-39 5TUR-A nrPDB 160 1e-39 3HMP-A nrPDB 160 2e-39 3UIM-A nrPDB 160 2e-39 3BGP-A nrPDB 160 2e-39 4Y83-A nrPDB 160 2e-39 4LQP-A nrPDB 159 3e-39 4RC3-A nrPDB 159 4e-39 5AP3-A nrPDB 158 6e-39 2ZMD-A nrPDB 158 7e-39 2BUJ-A nrPDB 157 1e-38 4NEU-A nrPDB 157 1e-38 3LLT-A nrPDB 155 4e-38 5IKW-A nrPDB 155 7e-38 2RIO-A nrPDB 154 1e-37 2JD5-A nrPDB 153 3e-37 2Y4I-B nrPDB 152 4e-37 5X18-A nrPDB 152 4e-37 5TE0-A nrPDB 152 6e-37 4PL5-B nrPDB 150 2e-36 4IAN-A nrPDB 150 3e-36 6HV0-A nrPDB 149 4e-36 4M66-A nrPDB 147 2e-35 5VD3-A nrPDB 146 3e-35 5XVU-A nrPDB 146 4e-35 6HMD-A nrPDB 142 5e-34 3G2F-A nrPDB 138 9e-33 4MWI-A nrPDB 135 5e-32 3REP-A nrPDB 135 6e-32 5J0A-A nrPDB 134 1e-31 4M69-B nrPDB 133 2e-31 4LFI-A nrPDB 132 4e-31 4BTK-A nrPDB 132 5e-31 4BTF-A nrPDB 132 6e-31 4NFN-A nrPDB 132 6e-31 5VDK-A nrPDB 128 9e-30 5VC6-A nrPDB 124 2e-28 2PMN-X nrPDB 122 6e-28 2CMW-A nrPDB 122 6e-28 2CHL-A nrPDB 119 3e-27 4F9B-A nrPDB 119 4e-27 2PZI-A nrPDB 116 4e-26 4Y12-A nrPDB 116 5e-26 5M07-A nrPDB 111 9e-25 5L2Q-C nrPDB 109 5e-24 5OAT-A nrPDB 99 1e-20 5CLR-A nrPDB 87 3e-17 4IX6-A nrPDB 74 3e-13 Sequences not found previously or not previously below threshold: 6FEX-A nrPDB 191 7e-49 6BSD-A nrPDB 189 3e-48 3TT0-A nrPDB 188 6e-48 5A46-A nrPDB 187 1e-47 3GQL-A nrPDB 187 1e-47 3ZBF-A nrPDB 185 5e-47 2PSQ-A nrPDB 184 1e-46 5EG3-A nrPDB 180 2e-45 2WO6-A nrPDB 165 6e-41 6J5U-C nrPDB 161 1e-39 4C59-A nrPDB 157 2e-38 1PY5-A nrPDB 152 4e-37 5WNL-A nrPDB 152 6e-37 2QKW-B nrPDB 151 1e-36 3MY0-A nrPDB 150 2e-36 3MDY-A nrPDB 147 1e-35 3Q4U-A nrPDB 146 4e-35 5AR8-A nrPDB 145 9e-35 4MD7-E nrPDB 145 9e-35 2PVN-A nrPDB 144 1e-34 6EII-A nrPDB 142 6e-34 6BFN-A nrPDB 139 4e-33 3SV0-A nrPDB 138 9e-33 2X7G-A nrPDB 136 4e-32 2H34-A nrPDB 135 5e-32 4WUA-A nrPDB 133 2e-31 3SOC-A nrPDB 133 2e-31 5E8V-A nrPDB 131 9e-31 4TN6-A nrPDB 128 9e-30 2WTK-B nrPDB 126 4e-29 3QD2-B nrPDB 125 9e-29 2QLU-A nrPDB 122 5e-28 3VHK-A nrPDB 122 6e-28 4L00-A nrPDB 119 4e-27 3HNG-A nrPDB 119 4e-27 5FQD-C nrPDB 117 2e-26 2C47-A nrPDB 116 3e-26 4NT4-A nrPDB 115 6e-26 5UV4-A nrPDB 115 1e-25 4RT7-A nrPDB 114 1e-25 1CSN-A nrPDB 114 1e-25 4XHH-A nrPDB 112 5e-25 5C01-A nrPDB 107 2e-23 4WOV-A nrPDB 106 3e-23 4XHL-A nrPDB 106 4e-23 5X1R-A nrPDB 105 5e-23 5CEK-A nrPDB 96 6e-20 6DC0-A nrPDB 96 7e-20 4L68-A nrPDB 95 8e-20 6EQI-C nrPDB 94 2e-19 6J6I-B nrPDB 89 6e-18 4I94-A nrPDB 85 7e-17 4JRN-A nrPDB 85 8e-17 5UU1-A nrPDB 81 2e-15 5DMZ-A nrPDB 75 9e-14 2LAV-A nrPDB 70 3e-12 2RSV-A nrPDB 70 3e-12 6EAS-A nrPDB 70 5e-12 6G4J-A nrPDB 68 1e-11 5GZA-A nrPDB 67 3e-11 5GZ9-A nrPDB 65 1e-10 4O1O-A nrPDB 64 3e-10 4CI6-B nrPDB 60 3e-09 2JII-A nrPDB 60 5e-09 4OAU-C nrPDB 58 2e-08 6BHC-A nrPDB 54 2e-07 6EWX-A nrPDB 53 4e-07 5VE6-A nrPDB 50 4e-06 4AZW-A nrPDB 50 5e-06 4CYJ-A nrPDB 49 6e-06 4AZV-A nrPDB 48 1e-05 6R5K-O nrPDB 48 1e-05 4XR7-L nrPDB 47 2e-05 4BWP-A nrPDB 47 4e-05 4WWA-A nrPDB 46 7e-05 3BYV-A nrPDB 45 1e-04 3ENH-A nrPDB 42 0.001 6M7Z-A nrPDB 42 0.001 3DZO-A nrPDB 42 0.001 6G38-A nrPDB 41 0.002 2W1Z-A nrPDB 41 0.002 4CZY-B nrPDB 40 0.005 1TQM-A nrPDB 39 0.006 6FAI-l nrPDB 36 0.069 5YK0-A nrPDB 35 0.11 5JY7-I nrPDB 33 0.57 2PZ1-A nrPDB 33 0.66 6J2C-O nrPDB 32 0.70 5LVV-A nrPDB 32 0.92 4L0O-H nrPDB 32 0.95 6G18-v nrPDB 32 0.98 6FDN-A nrPDB 32 1.1 >6NT9-A nrPDB Length = 742 Score = 1253 bits (3243), Expect = 0.0, Method: Composition-based stats. Identities = 728/729 (99%), Positives = 729/729 (100%) Query: 1 MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLK 60 MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLK Sbjct: 1 MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLK 60 Query: 61 KLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVV 120 KLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVV Sbjct: 61 KLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVV 120 Query: 121 GGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYL 180 GGMNHLRENGIVHR+IKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYL Sbjct: 121 GGMNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYL 180 Query: 181 HPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITG 240 HPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITG Sbjct: 181 HPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITG 240 Query: 241 KPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFA 300 KPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFA Sbjct: 241 KPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFA 300 Query: 301 ETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLV 360 ETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLV Sbjct: 301 ETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLV 360 Query: 361 LEPGRLAQHFPKTTEENPIFVVSREPLNTIGLIYEKISLPKVHPRYDLDGDASMAKAITG 420 LEPGRLAQHFPKTTEENPIFVVSREPLNTIGLIYEKISLPKVHPRYDLDGDASMAKAITG Sbjct: 361 LEPGRLAQHFPKTTEENPIFVVSREPLNTIGLIYEKISLPKVHPRYDLDGDASMAKAITG 420 Query: 421 VVCYACRIASTLLLYQELMRKGIRWLIELIKDDYNETVHKKTEVVITLDFCIRNIEKTVK 480 VVCYACRIASTLLLYQELMRKGIRWLIELIKDDYNETVHKKTEVVITLDFCIRNIEKTVK Sbjct: 421 VVCYACRIASTLLLYQELMRKGIRWLIELIKDDYNETVHKKTEVVITLDFCIRNIEKTVK 480 Query: 481 VYEKLMKINLEAAELGEISDIHTKLLRLSSSQGTIETSLQDIDSRLSPGGSLADAWAHQE 540 VYEKLMKINLEAAELGEISDIHTKLLRLSSSQGTIETSLQDIDSRLSPGGSLADAWAHQE Sbjct: 481 VYEKLMKINLEAAELGEISDIHTKLLRLSSSQGTIETSLQDIDSRLSPGGSLADAWAHQE 540 Query: 541 GTHPKDRNVEKLQVLLNCMTEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAMTH 600 GTHPKDRNVEKLQVLLNCMTEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAMTH Sbjct: 541 GTHPKDRNVEKLQVLLNCMTEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAMTH 600 Query: 601 FTDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQCFDIEEEVSKYQEYTNELQETLPQ 660 FTDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQCFDIEEEVSKYQEYTNELQETLPQ Sbjct: 601 FTDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQCFDIEEEVSKYQEYTNELQETLPQ 660 Query: 661 KMFTASSGIKHTMTPIYPSSNTLVEMTLGMKKLKEEMEGVVKELAENNHILERFGSLTMD 720 KMFTASSGIKHTMTPIYPSSNTLVEMTLGMKKLKEEMEGVVKELAENNHILERFGSLTMD Sbjct: 661 KMFTASSGIKHTMTPIYPSSNTLVEMTLGMKKLKEEMEGVVKELAENNHILERFGSLTMD 720 Query: 721 GGLRNVDCL 729 GGLRNVDCL Sbjct: 721 GGLRNVDCL 729 >6O8B-A nrPDB Length = 665 Score = 1106 bits (2862), Expect = 0.0, Method: Composition-based stats. Identities = 652/656 (99%), Positives = 655/656 (99%) Query: 2 QSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKK 61 QSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKK Sbjct: 10 QSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKK 69 Query: 62 LNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVG 121 LNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVG Sbjct: 70 LNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVG 129 Query: 122 GMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLH 181 GMNHLRENGIVHR+IKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFV LYGTEEYLH Sbjct: 130 GMNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVELYGTEEYLH 189 Query: 182 PDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 241 PDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK Sbjct: 190 PDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 249 Query: 242 PSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFAE 301 PSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFAE Sbjct: 250 PSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFAE 309 Query: 302 TSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLVL 361 TSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLVL Sbjct: 310 TSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLVL 369 Query: 362 EPGRLAQHFPKTTEENPIFVVSREPLNTIGLIYEKISLPKVHPRYDLDGDASMAKAITGV 421 EPGRLAQHFPKTTEENPIFVVSREPL+TIGLIYEKISLPKVHPRYDLDGDASMAKAITGV Sbjct: 370 EPGRLAQHFPKTTEENPIFVVSREPLDTIGLIYEKISLPKVHPRYDLDGDASMAKAITGV 429 Query: 422 VCYACRIASTLLLYQELMRKGIRWLIELIKDDYNETVHKKTEVVITLDFCIRNIEKTVKV 481 VCYACRIASTLLLYQELMRKGIRWLIELIKDDYNETVHKKTEVVITLDFCIRNIEKTVKV Sbjct: 430 VCYACRIASTLLLYQELMRKGIRWLIELIKDDYNETVHKKTEVVITLDFCIRNIEKTVKV 489 Query: 482 YEKLMKINLEAAELGEISDIHTKLLRLSSSQGTIETSLQDIDSRLSPGGSLADAWAHQEG 541 YEKLMKINLEAAELGEISDIHTKLLRLSSSQGTIETSLQDIDSRLSPGGSLADAWAHQEG Sbjct: 490 YEKLMKINLEAAELGEISDIHTKLLRLSSSQGTIETSLQDIDSRLSPGGSLADAWAHQEG 549 Query: 542 THPKDRNVEKLQVLLNCMTEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAMTHF 601 THPKDRNVEKLQVLLNCMTEIYYQFKKD+AERRLAYNEEQIHKFDKQKLYYHATKAMTHF Sbjct: 550 THPKDRNVEKLQVLLNCMTEIYYQFKKDQAERRLAYNEEQIHKFDKQKLYYHATKAMTHF 609 Query: 602 TDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQCFDIEEEVSKYQEYTNELQET 657 TDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQCFDIEEEVSKYQEYTNELQET Sbjct: 610 TDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQCFDIEEEVSKYQEYTNELQET 665 >4JLC-A nrPDB Length = 657 Score = 1086 bits (2808), Expect = 0.0, Method: Composition-based stats. Identities = 618/655 (94%), Positives = 643/655 (98%) Query: 2 QSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKK 61 QSTSNHLWLLSDILGQGATANVFRGRHKKTGDL+A+KVFNNISFLRPVDVQMREFEVLKK Sbjct: 3 QSTSNHLWLLSDILGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQMREFEVLKK 62 Query: 62 LNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVG 121 LNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVG Sbjct: 63 LNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVG 122 Query: 122 GMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLH 181 GMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLH Sbjct: 123 GMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLH 182 Query: 182 PDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 241 PDMYERAVLRKDHQKKYGATVDLWS+GVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK Sbjct: 183 PDMYERAVLRKDHQKKYGATVDLWSVGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 242 Query: 242 PSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFAE 301 PSGAISGVQKAENGPIDWSGDMP+SCSLS+GLQ LLTPVLANILEADQEKCWGFDQFFAE Sbjct: 243 PSGAISGVQKAENGPIDWSGDMPLSCSLSQGLQALLTPVLANILEADQEKCWGFDQFFAE 302 Query: 302 TSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLVL 361 TSD+LHRMVIHVFSLQ MTAHKIYIHSYNTA +FHELVYKQTKI+SSNQELIYEGRRLVL Sbjct: 303 TSDVLHRMVIHVFSLQHMTAHKIYIHSYNTAAVFHELVYKQTKIVSSNQELIYEGRRLVL 362 Query: 362 EPGRLAQHFPKTTEENPIFVVSREPLNTIGLIYEKISLPKVHPRYDLDGDASMAKAITGV 421 E GRLAQHFPKTTEENPIFV SRE LNT+GL YEKISLPK+HPRYDLDGDASMAKA+TGV Sbjct: 363 ELGRLAQHFPKTTEENPIFVTSREQLNTVGLRYEKISLPKIHPRYDLDGDASMAKAVTGV 422 Query: 422 VCYACRIASTLLLYQELMRKGIRWLIELIKDDYNETVHKKTEVVITLDFCIRNIEKTVKV 481 VCYACR ASTLLLYQELMRKG+RWL+EL+KDDYNETVHKKTEVVITLDFCIRNIEKTVKV Sbjct: 423 VCYACRTASTLLLYQELMRKGVRWLVELVKDDYNETVHKKTEVVITLDFCIRNIEKTVKV 482 Query: 482 YEKLMKINLEAAELGEISDIHTKLLRLSSSQGTIETSLQDIDSRLSPGGSLADAWAHQEG 541 YEKLMK+NLEAAELGEISDIHTKLLRLSSSQGTIE+SLQDI SRLSPGG LAD WAHQEG Sbjct: 483 YEKLMKVNLEAAELGEISDIHTKLLRLSSSQGTIESSLQDISSRLSPGGLLADTWAHQEG 542 Query: 542 THPKDRNVEKLQVLLNCMTEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAMTHF 601 THP+DRNVEKLQVLLNC+TEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAM+HF Sbjct: 543 THPRDRNVEKLQVLLNCITEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAMSHF 602 Query: 602 TDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQCFDIEEEVSKYQEYTNELQE 656 ++ECV+KYEAF +KSEEW+RKMLHLRKQLLSLTNQCFDIEEEVSKYQ+YTNELQE Sbjct: 603 SEECVRKYEAFKDKSEEWMRKMLHLRKQLLSLTNQCFDIEEEVSKYQDYTNELQE 657 >4EUT-A nrPDB Length = 396 Score = 563 bits (1450), Expect = e-160, Method: Composition-based stats. Identities = 383/384 (99%), Positives = 384/384 (100%) Query: 2 QSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKK 61 QSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKK Sbjct: 4 QSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKK 63 Query: 62 LNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVG 121 LNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVG Sbjct: 64 LNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVG 123 Query: 122 GMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLH 181 GMNHLRENGIVHR+IKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLH Sbjct: 124 GMNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLH 183 Query: 182 PDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 241 PDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK Sbjct: 184 PDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 243 Query: 242 PSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFAE 301 PSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFAE Sbjct: 244 PSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFAE 303 Query: 302 TSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLVL 361 TSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLVL Sbjct: 304 TSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLVL 363 Query: 362 EPGRLAQHFPKTTEENPIFVVSRE 385 EPGRLAQHFPKTTEENPIFVVSRE Sbjct: 364 EPGRLAQHFPKTTEENPIFVVSRE 387 >4EUU-A nrPDB Length = 319 Score = 435 bits (1118), Expect = e-122, Method: Composition-based stats. Identities = 307/311 (98%), Positives = 308/311 (99%) Query: 2 QSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKK 61 QSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKK Sbjct: 4 QSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKK 63 Query: 62 LNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVG 121 LNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVG Sbjct: 64 LNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVG 123 Query: 122 GMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLH 181 GMNHLRENGIVHR+IKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLH Sbjct: 124 GMNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLH 183 Query: 182 PDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 241 PDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK Sbjct: 184 PDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 243 Query: 242 PSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFAE 301 PSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFAE Sbjct: 244 PSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFAE 303 Query: 302 TSDILHRMVIH 312 TSDILHR H Sbjct: 304 TSDILHRGNSH 314 >4KIK-B nrPDB Length = 677 Score = 327 bits (839), Expect = 1e-89, Method: Composition-based stats. Identities = 103/368 (27%), Positives = 165/368 (44%), Gaps = 24/368 (6%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIV 68 W + + LG G NV R +++TG+ AIK R + E +++++L H N+V Sbjct: 21 WEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQIMRRLTHPNVV 80 Query: 69 KLFAIEEE----TTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 124 + E +L ME+C G L L + N GL E L +L D+ + Sbjct: 81 AARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALR 140 Query: 125 HLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDM 184 +L EN I+HRD+KP NI+ GE + ++K+ D G A+EL+ S GT +YL P++ Sbjct: 141 YLHENRIIHRDLKPENIVLQQGEQ-RLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPEL 199 Query: 185 YERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSG 244 E Q+KY TVD WS G + TG PF P P + + + S Sbjct: 200 LE--------QQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQ-----KSE 246 Query: 245 AISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANIL-----EADQEKCWGFDQFF 299 V + NG + +S +P +L+ L L L +L + + +G + F Sbjct: 247 VDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCF 306 Query: 300 AETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRL 359 DIL+ ++H+ ++ T H + + + + T I +QEL+ E L Sbjct: 307 KALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQEA-GL 365 Query: 360 VLEPGRLA 367 L P + A Sbjct: 366 ALIPDKPA 373 >5TQX-A nrPDB Length = 655 Score = 306 bits (784), Expect = 2e-83, Method: Composition-based stats. Identities = 106/375 (28%), Positives = 171/375 (45%), Gaps = 31/375 (8%) Query: 8 LWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNI 67 W + + LG G NV +H++ AIK + + E +++KKLNH N+ Sbjct: 9 PWEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCHEIQIMKKLNHANV 68 Query: 68 VKLFAIEEETT---TRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 124 VK + EE +L ME+C G L +L +P N GL ES+ L +L D+ G+ Sbjct: 69 VKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSGIR 128 Query: 125 HLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDM 184 +L EN I+HRD+KP NI+ G+ ++K+ D G A++++ E GT +YL P++ Sbjct: 129 YLHENKIIHRDLKPENIVL-QDVGGKIIHKIIDLGYAKDVDQGELCTEFVGTLQYLAPEL 187 Query: 185 YERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSG 244 +E K Y ATVD WS G + G PF P E + K K Sbjct: 188 FE--------NKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKK----KDPK 235 Query: 245 AISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGF-------DQ 297 I ++ +G + +S +P SL + + L +L D ++ G + Sbjct: 236 CIFACEEM-SGEVRFSSHLPQPNSLCSLIVEPMENWLQLMLNWDPQQRGGPVDLTLKQPR 294 Query: 298 FFAETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHEL---VYKQTKIISSNQELIY 354 F IL+ ++H+ + MT+ KI H L + ++T I + +QEL+ Sbjct: 295 CFVLMDHILNLKIVHILN---MTSAKIISFLLPPDESLHSLQSRIERETGINTGSQELLS 351 Query: 355 EGRRLVLEPGRLAQH 369 E + L+P + A Sbjct: 352 E-TGISLDPRKPASQ 365 >3QA8-A nrPDB Length = 676 Score = 285 bits (729), Expect = 6e-77, Method: Composition-based stats. Identities = 110/415 (26%), Positives = 166/415 (40%), Gaps = 39/415 (9%) Query: 8 LWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNI 67 W + + LG G V R H+ TG+ AIK + + E +++KKLNH N+ Sbjct: 15 PWEMKERLGTGGFGYVLRWIHQDTGEQVAIKQCRQELSPKNRERWCLEIQIMKKLNHPNV 74 Query: 68 VKLFAIEEE----TTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 123 V + + +L ME+C G L L + N GL E +L D+ + Sbjct: 75 VSAREVPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGPIRTLLSDISSAL 134 Query: 124 NHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPD 183 +L EN I+HRD+KP NI+ G + ++K+ D G A+EL+ E GT +YL P+ Sbjct: 135 RYLHENRIIHRDLKPENIVLQPGPQ-RLIHKIIDLGYAKELDQGELCTEFVGTLQYLAPE 193 Query: 184 MYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS 243 + E QKKY TVD WS G + TG PF P P + + + S Sbjct: 194 LLE--------QKKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHGKVR-----EKS 240 Query: 244 GAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQ-----F 298 V G + +S +P LS L L L +L Q + Q Sbjct: 241 NEHIVVYDDLTGAVKFSSVLPTPNHLSGILAGKLERWLQCMLMWHQRQRGTDPQNPNVGC 300 Query: 299 FAETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRR 358 F IL ++ V ++ H + + + T I QEL+ Sbjct: 301 FQALDSILSLKLLSVMNMVSGRVHTYPVTENENLQNLKSWLQQDTGIPEEEQELLQ-ASG 359 Query: 359 LVLEPGRLAQHF--------PKTTEENPIFVVSREPLNTIGLIYE-KISLPKVHP 404 L L + + + E + IF+ + +YE +ISLP HP Sbjct: 360 LALNSAQPLTQYVIDCTVIDGRQGEGDLIFL-----FDNRKTVYEPQISLP-AHP 408 >3NCG-A nrPDB Length = 486 Score = 254 bits (649), Expect = 1e-67, Method: Composition-based stats. Identities = 80/319 (25%), Positives = 139/319 (43%), Gaps = 44/319 (13%) Query: 1 MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFL-RPVDVQMREFEVL 59 Q T + + +LG+G+ V + + + T +A+KV N S + +RE E+L Sbjct: 16 FQGTFAERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELL 75 Query: 60 KKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDV 119 KKL+H NI+KLF I E++++ ++ E G L+ + + E + +++ V Sbjct: 76 KKLDHPNIMKLFEILEDSSS--FYIVGELYTGGELFDEIIKRKR---FSEHDAARIIKQV 130 Query: 120 VGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEY 179 G+ ++ ++ IVHRD+KP NI+ E K+ DFG + + + + GT Y Sbjct: 131 FSGITYMHKHNIVHRDLKPENILLESKEK-DCDIKIIDFGLSTCFQQNTKMKDRIGTAYY 189 Query: 180 LHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRP---------------- 223 + P++ Y D+WS GV Y +G+ PF Sbjct: 190 IAPEVLRG---------TYDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRVETGKYA 240 Query: 224 FEGPR------RNKEVMYKIITGKPSGAISGVQKAENGPID-WSGDMPVSCSLSRGLQVL 276 F+ P+ K+++ K++T PS I+ Q E+ I +S + P L Sbjct: 241 FDLPQWRTISDDAKDLIRKMLTFHPSLRITATQCLEHPWIQKYSSETPTISDLPS----- 295 Query: 277 LTPVLANILEADQEKCWGF 295 L + NI + EK Sbjct: 296 LESAMTNIRQFQAEKKLAQ 314 >3DFA-A nrPDB Length = 286 Score = 244 bits (624), Expect = 7e-65, Method: Composition-based stats. Identities = 72/281 (25%), Positives = 127/281 (45%), Gaps = 38/281 (13%) Query: 1 MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFL-RPVDVQMREFEVL 59 Q T + + +LG+G+ V + + + T +A+KV N S + +RE E+L Sbjct: 16 FQGTFAERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELL 75 Query: 60 KKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDV 119 KKL+H NI+KLF I E++++ ++ E G L+ + + E + +++ V Sbjct: 76 KKLDHPNIMKLFEILEDSSS--FYIVGELYTGGELFDEIIKRKR---FSEHDAARIIKQV 130 Query: 120 VGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEY 179 G+ ++ ++ IVHRD+KP NI+ E K+ DFG + + + + GT Y Sbjct: 131 FSGITYMHKHNIVHRDLKPENILLESKEK-DCDIKIIDFGLSTCFQQNTKMKDRIGTAYY 189 Query: 180 LHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRP---------------- 223 + P++ Y D+WS GV Y +G+ PF Sbjct: 190 IAPEVLRG---------TYDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRVETGKYA 240 Query: 224 FEGPR------RNKEVMYKIITGKPSGAISGVQKAENGPID 258 F+ P+ K+++ K++T PS I+ Q E+ I Sbjct: 241 FDLPQWRTISDDAKDLIRKMLTFHPSLRITATQCLEHPWIQ 281 >6FDY-U nrPDB Length = 276 Score = 241 bits (614), Expect = 1e-63, Method: Composition-based stats. Identities = 85/294 (28%), Positives = 131/294 (44%), Gaps = 43/294 (14%) Query: 9 WLLSDILGQGATANVFRGR-HKKTGDLFAIKVFNNISFLR-PVDVQMREFEVLKKLNHKN 66 ++L++ LG G A V++ K T ++ AIK S + V+ + E E+LK + H + Sbjct: 13 FILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKGIRHPH 72 Query: 67 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 126 IV+L + + + LIMEFC G L + LPE + ++ + + L Sbjct: 73 IVQLKDF--QWDSDNIYLIMEFCAGGDLSRFIHTRR---ILPEKVARVFMQQLASALQFL 127 Query: 127 RENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYE 186 E I H D+KP NI+ E + KL DFG A+ + ++ L G+ Y+ P+M Sbjct: 128 HERNISHLDLKPQNILLSSLE--KPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMV- 184 Query: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAI 246 Q++Y A VDLWS+GV Y A G PF R E+ KI + + Sbjct: 185 -------CQRQYDARVDLWSMGVILYEALFGQPPF----ASRSFSELEEKIRSNR----- 228 Query: 247 SGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFA 300 ++P+ LSR + L L +LE D + F FFA Sbjct: 229 -------------VIELPLRPLLSRDCRDL----LQRLLERDPSRRISFQDFFA 265 >4MVF-A nrPDB Length = 506 Score = 239 bits (611), Expect = 2e-63, Method: Composition-based stats. Identities = 69/236 (29%), Positives = 109/236 (46%), Gaps = 20/236 (8%) Query: 6 NHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHK 65 +++ + LGQG V++G K T L+AIK L+ ++ +E E++KKL+H Sbjct: 56 EDKYIIDEKLGQGTYGCVYKGIDKVTNQLYAIKE-EKKDRLKNINRFFQEIEIMKKLDHP 114 Query: 66 NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 125 NIVKL+ E + LIME C L+ + E + E +++ + + + Sbjct: 115 NIVKLYETYENDN--YIYLIMELCSGRELFDSIIENGS---FTEKNAATIMKQIFSAIFY 169 Query: 126 LRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMY 185 L IVHRD+KP N + E+ S+ K+ DFG ++ L E + GT Y+ P + Sbjct: 170 LHSLNIVHRDLKPENFLF-QSENKDSLLKIIDFGLSKNLGTGEFTTTKAGTPYYVAPQVL 228 Query: 186 ERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 241 KY D+WS GV Y G PF + EV+ K+ G+ Sbjct: 229 ---------DGKYDKKCDIWSSGVIMYTLLCGYPPFYG----DTDNEVLKKVKKGE 271 >3LIJ-A nrPDB Length = 494 Score = 237 bits (606), Expect = 9e-63, Method: Composition-based stats. Identities = 77/293 (26%), Positives = 131/293 (44%), Gaps = 41/293 (13%) Query: 6 NHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNIS-FLRPVDVQMREFEVLKKLNH 64 + ++ LG GA V R K T AIK+ S + E VLK L+H Sbjct: 36 SEMYQRVKKLGSGAYGEVLLCRDKVTHVERAIKIIRKTSVSTSSNSKLLEEVAVLKLLDH 95 Query: 65 KNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 124 NI+KL+ E+ R+ L+ME G L+ E + E + ++++ V+ G+ Sbjct: 96 PNIMKLYDFFED--KRNYYLVMECYKGGELFD---EIIHRMKFNEVDAAVIIKQVLSGVT 150 Query: 125 HLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDM 184 +L ++ IVHRD+KP N++ E ++ K+ DFG + E+ ++ GT Y+ P++ Sbjct: 151 YLHKHNIVHRDLKPENLLLESKEK-DALIKIVDFGLSAVFENQKKMKERLGTAYYIAPEV 209 Query: 185 YERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSG 244 KKY D+WSIGV + G PF G + ++E++ K+ GK Sbjct: 210 LR---------KKYDEKCDVWSIGVILFILLAGYPPF----GGQTDQEILRKVEKGK--- 253 Query: 245 AISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQ 297 ++ D P ++S G + L + +L+ D ++ Q Sbjct: 254 --------------YTFDSPEWKNVSEGAKDL----IKQMLQFDSQRRISAQQ 288 >2HAK-A nrPDB Length = 328 Score = 237 bits (606), Expect = 9e-63, Method: Composition-based stats. Identities = 71/235 (30%), Positives = 111/235 (47%), Gaps = 23/235 (9%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISF-LRPVDVQMREFEVLKKLNHKNI 67 + L +G+G A V RH TG A+K+ + + RE ++K LNH NI Sbjct: 17 YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNI 76 Query: 68 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 127 VKLF + E T + L+ME+ G ++ L + E E R +V + + Sbjct: 77 VKLFEVIE--TEKTLYLVMEYASGGEVFDYLVAHGR---MKEKEARAKFRQIVSAVQYCH 131 Query: 128 ENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYER 187 + IVHRD+K N++ DG K+ DFG + E + + G+ Y P++++ Sbjct: 132 QKYIVHRDLKAENLLL----DGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQG 187 Query: 188 AVLRKDHQKKY-GATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 241 KKY G VD+WS+GV Y +GSLPF + KE+ +++ GK Sbjct: 188 --------KKYDGPEVDVWSLGVILYTLVSGSLPFDG----QNLKELRERVLRGK 230 >5ES1-A nrPDB Length = 328 Score = 236 bits (603), Expect = 2e-62, Method: Composition-based stats. Identities = 71/235 (30%), Positives = 112/235 (47%), Gaps = 23/235 (9%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISF-LRPVDVQMREFEVLKKLNHKNI 67 + L +G+G A V RH TG AIK+ + + RE ++K LNH NI Sbjct: 17 YRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNI 76 Query: 68 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 127 VKLF + E T + L+ME+ G ++ L + E E R +V +++ Sbjct: 77 VKLFEVIE--TEKTLYLVMEYASAGEVFDYLVSHGR---MKEKEARAKFRQIVSAVHYCH 131 Query: 128 ENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYER 187 + IVHRD+K N++ D ++ K+ DFG + E + + G+ Y P++++ Sbjct: 132 QKNIVHRDLKAENLLL----DAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQG 187 Query: 188 AVLRKDHQKKY-GATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 241 KKY G VD+WS+GV Y +GSLPF KE+ +++ GK Sbjct: 188 --------KKYDGPEVDIWSLGVILYTLVSGSLPFDGH----NLKELRERVLRGK 230 >3DXN-A nrPDB Length = 287 Score = 236 bits (602), Expect = 3e-62, Method: Composition-based stats. Identities = 70/245 (28%), Positives = 112/245 (45%), Gaps = 22/245 (8%) Query: 1 MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVD--VQMREFEV 58 Q S+ + LG GA V + K TG AIK+ S + + E V Sbjct: 16 FQGLSDRYQRVKK-LGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAV 74 Query: 59 LKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRD 118 LK+L+H NI+KL+ E+ R+ L+ME G L+ E E + ++++ Sbjct: 75 LKQLDHPNIMKLYEFFED--KRNYYLVMEVYRGGELFD---EIILRQKFSEVDAAVIMKQ 129 Query: 119 VVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEE 178 V+ G +L ++ IVHRD+KP N++ ++ K+ DFG + E + GT Sbjct: 130 VLSGTTYLHKHNIVHRDLKPENLLLESKSR-DALIKIVDFGLSAHFEVGGKMKERLGTAY 188 Query: 179 YLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKII 238 Y+ P++ KKY D+WS GV Y G PF G + ++E++ ++ Sbjct: 189 YIAPEVLR---------KKYDEKCDVWSCGVILYILLCGYPPF----GGQTDQEILKRVE 235 Query: 239 TGKPS 243 GK S Sbjct: 236 KGKFS 240 >6C9D-A nrPDB Length = 459 Score = 236 bits (602), Expect = 3e-62, Method: Composition-based stats. Identities = 71/235 (30%), Positives = 110/235 (46%), Gaps = 23/235 (9%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISF-LRPVDVQMREFEVLKKLNHKNI 67 + L +G+G A V RH TG A+K+ + + RE ++K LNH NI Sbjct: 23 YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNI 82 Query: 68 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 127 VKLF + E T + L+ME+ G ++ L + E E R +V + + Sbjct: 83 VKLFEVIE--TEKTLYLVMEYASGGEVFDYLVAHGR---MKEKEARAKFRQIVSAVQYCH 137 Query: 128 ENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYER 187 + IVHRD+K N++ DG K+ DFG + E + G+ Y P++++ Sbjct: 138 QKYIVHRDLKAENLLL----DGDMNIKIADFGFSNEFTVGNKLDEFCGSPPYAAPELFQG 193 Query: 188 AVLRKDHQKKY-GATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 241 KKY G VD+WS+GV Y +GSLPF + KE+ +++ GK Sbjct: 194 --------KKYDGPEVDVWSLGVILYTLVSGSLPFDG----QNLKELRERVLRGK 236 >2QNJ-A nrPDB Length = 328 Score = 236 bits (601), Expect = 4e-62, Method: Composition-based stats. Identities = 73/258 (28%), Positives = 115/258 (44%), Gaps = 26/258 (10%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISF-LRPVDVQMREFEVLKKLNHKNI 67 + L +G+G A V RH TG AIK+ + + RE ++K LNH NI Sbjct: 14 YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNI 73 Query: 68 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 127 VKLF + E T + LIME+ G ++ L + E E R +V + + Sbjct: 74 VKLFEVIE--TEKTLYLIMEYASGGEVFDYLVAHGR---MKEKEARSKFRQIVSAVQYCH 128 Query: 128 ENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYER 187 + IVHRD+K N++ D K+ DFG + E + + G+ Y P++++ Sbjct: 129 QKRIVHRDLKAENLLL----DADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQG 184 Query: 188 AVLRKDHQKKY-GATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK---PS 243 KKY G VD+WS+GV Y +GSLPF + KE+ +++ GK P Sbjct: 185 --------KKYDGPEVDVWSLGVILYTLVSGSLPFDG----QNLKELRERVLRGKYRIPF 232 Query: 244 GAISGVQKAENGPIDWSG 261 + + + + Sbjct: 233 YMSTDCENLLKRFLVLNP 250 >5JN2-A nrPDB Length = 525 Score = 234 bits (598), Expect = 7e-62, Method: Composition-based stats. Identities = 65/282 (23%), Positives = 123/282 (43%), Gaps = 38/282 (13%) Query: 3 STSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLK 60 + + + +LG+G+ V + K TG A+KV + + D + +RE ++LK Sbjct: 63 AIFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLK 122 Query: 61 KLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVV 120 +L+H NI+KL+ E+ + L+ E G L+ E + E + ++R V+ Sbjct: 123 QLDHPNIMKLYEFFED--KGYFYLVGEVYTGGELFD---EIISRKRFSEVDAARIIRQVL 177 Query: 121 GGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYL 180 G+ ++ +N IVHRD+KP N++ + + ++ DFG + E ++ GT Y+ Sbjct: 178 SGITYMHKNKIVHRDLKPENLLLE-SKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYI 236 Query: 181 HPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITG 240 P++ Y D+WS GV Y +G PF +++ K+ G Sbjct: 237 APEVL---------HGTYDEKCDVWSTGVILYILLSGCPPF----NGANEYDILKKVEKG 283 Query: 241 KPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLA 282 K ++ ++P +S + L+ +L Sbjct: 284 K-----------------YTFELPQWKKVSESAKDLIRKMLT 308 >5KZ7-A nrPDB Length = 346 Score = 234 bits (597), Expect = 9e-62, Method: Composition-based stats. Identities = 71/254 (27%), Positives = 114/254 (44%), Gaps = 26/254 (10%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISF-LRPVDVQMREFEVLKKLNHKNI 67 + L +G+G A V RH TG A+K+ + + RE ++K LNH NI Sbjct: 35 YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNI 94 Query: 68 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 127 VKLF + E T + L+ME+ G ++ L + E E R +V + + Sbjct: 95 VKLFEVIE--TEKTLYLVMEYASGGEVFDYLVAHGR---MKEKEARAKFRQIVSAVQYCH 149 Query: 128 ENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYER 187 + IVHRD+K N++ D K+ DFG + E + + G+ Y P++++ Sbjct: 150 QKFIVHRDLKAENLLL----DADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQG 205 Query: 188 AVLRKDHQKKY-GATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK---PS 243 KKY G VD+WS+GV Y +GSLPF + KE+ +++ GK P Sbjct: 206 --------KKYDGPEVDVWSLGVILYTLVSGSLPFDG----QNLKELRERVLRGKYRIPF 253 Query: 244 GAISGVQKAENGPI 257 + + + Sbjct: 254 YMSTDCENLLKKFL 267 >3HZT-A nrPDB Length = 467 Score = 234 bits (597), Expect = 1e-61, Method: Composition-based stats. Identities = 68/240 (28%), Positives = 110/240 (45%), Gaps = 21/240 (8%) Query: 6 NHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVD--VQMREFEVLKKLN 63 + + LG GA V + K TG AIK+ S + + E VLK+L+ Sbjct: 3 SDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLD 62 Query: 64 HKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 123 H NI+KL+ E+ R+ L+ME G L+ E E + ++++ V+ G Sbjct: 63 HPNIMKLYEFFED--KRNYYLVMEVYRGGELFD---EIILRQKFSEVDAAVIMKQVLSGT 117 Query: 124 NHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPD 183 +L ++ IVHRD+KP N++ ++ K+ DFG + E + GT Y+ P+ Sbjct: 118 TYLHKHNIVHRDLKPENLLLESKSR-DALIKIVDFGLSAHFEVGGKMKERLGTAYYIAPE 176 Query: 184 MYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS 243 + KKY D+WS GV Y G PF G + ++E++ ++ GK S Sbjct: 177 VLR---------KKYDEKCDVWSCGVILYILLCGYPPF----GGQTDQEILKRVEKGKFS 223 >3Q5I-A nrPDB Length = 504 Score = 233 bits (594), Expect = 3e-61, Method: Composition-based stats. Identities = 67/252 (26%), Positives = 111/252 (44%), Gaps = 31/252 (12%) Query: 2 QSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPV------------ 49 + + LG GA V + K AIKV F + Sbjct: 31 EGKIGESYFKVRKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYSDDNKNIEKFH 90 Query: 50 DVQMREFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPE 109 + E +LK L+H NI+KLF + E+ ++ L+ EF G L+ E+ N + E Sbjct: 91 EEIYNEISLLKSLDHPNIIKLFDVFED--KKYFYLVTEFYEGGELF---EQIINRHKFDE 145 Query: 110 SEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQ 169 + +++ ++ G+ +L ++ IVHRDIKP NI+ ++ K+ DFG + D + Sbjct: 146 CDAANIMKQILSGICYLHKHNIVHRDIKPENILLE-NKNSLLNIKIVDFGLSSFFSKDYK 204 Query: 170 FVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRR 229 GT Y+ P++ + KKY D+WS GV Y G PF G + Sbjct: 205 LRDRLGTAYYIAPEVLK---------KKYNEKCDVWSCGVIMYILLCGYPPF----GGQN 251 Query: 230 NKEVMYKIITGK 241 +++++ K+ GK Sbjct: 252 DQDIIKKVEKGK 263 >3MA6-A nrPDB Length = 298 Score = 232 bits (591), Expect = 5e-61, Method: Composition-based stats. Identities = 65/282 (23%), Positives = 123/282 (43%), Gaps = 38/282 (13%) Query: 3 STSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLK 60 + + + +LG+G+ V + K TG A+KV + + D + +RE ++LK Sbjct: 28 AIFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLK 87 Query: 61 KLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVV 120 +L+H NI+KL+ E+ + L+ E G L+ E + E + ++R V+ Sbjct: 88 QLDHPNIMKLYEFFED--KGYFYLVGEVYTGGELFD---EIISRKRFSEVDAARIIRQVL 142 Query: 121 GGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYL 180 G+ ++ +N IVHRD+KP N++ + + ++ DFG + E ++ GT Y+ Sbjct: 143 SGITYMHKNKIVHRDLKPENLLLE-SKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYI 201 Query: 181 HPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITG 240 P++ Y D+WS GV Y +G PF +++ K+ G Sbjct: 202 APEVL---------HGTYDEKCDVWSTGVILYILLSGCPPF----NGANEYDILKKVEKG 248 Query: 241 KPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLA 282 K ++ ++P +S + L+ +L Sbjct: 249 K-----------------YTFELPQWKKVSESAKDLIRKMLT 273 >4WNO-A nrPDB Length = 287 Score = 231 bits (589), Expect = 8e-61, Method: Composition-based stats. Identities = 73/238 (30%), Positives = 110/238 (46%), Gaps = 20/238 (8%) Query: 12 SDILGQGATANVFRGRHKKTGD-LFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKL 70 D++G GA A VF+GRH+ D A+K N + + + +E ++LK+L H+NIV L Sbjct: 23 KDLIGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVAL 82 Query: 71 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 130 + +E + L+ME+C G L L L E + L+ + G M L G Sbjct: 83 YDFQEMANS--VYLVMEYCNGGDLADYLHAMR---TLSEDTIRLFLQQIAGAMRLLHSKG 137 Query: 131 IVHRDIKPGNIMRVIG-----EDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMY 185 I+HRD+KP NI+ K+ DFG AR L+ + +L G+ Y+ P++ Sbjct: 138 IIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVI 197 Query: 186 ERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS 243 + Y DLWSIG Y TG PF+ P+ + K T P+ Sbjct: 198 M--------SQHYDGKADLWSIGTIVYQCLTGKAPFQA-SSPQDLRLFYEKNKTLVPT 246 >6QAU-A nrPDB Length = 280 Score = 231 bits (589), Expect = 9e-61, Method: Composition-based stats. Identities = 77/249 (30%), Positives = 115/249 (46%), Gaps = 20/249 (8%) Query: 1 MQSTSNHLWLLSDILGQGATANVFRGRHK-KTGDLFAIKVFNNISFLRPVDVQMREFEVL 59 M+ + + D++G GA A VFRGRH+ KT AIK N + + + +E ++L Sbjct: 5 MEVVGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKIL 64 Query: 60 KKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDV 119 K+L H+NIV L+ ++E + L+ME+C G L L+ L E + L + Sbjct: 65 KELQHENIVALYDVQELPNS--VFLVMEYCNGGDLADYLQAKG---TLSEDTIRVFLHQI 119 Query: 120 VGGMNHLRENGIVHRDIKPGNIMRVIGEDGQS-----VYKLTDFGAARELEDDEQFVSLY 174 M L GI+HRD+KP NI+ +S K+ DFG AR L + L Sbjct: 120 AAAMRILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAADLC 179 Query: 175 GTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVM 234 G+ Y+ P++ + Y A DLWSIG Y G PF+ P+ + Sbjct: 180 GSPMYMAPEVIM--------SQHYDAKADLWSIGTVIYQCLVGKPPFQA-NSPQDLRMFY 230 Query: 235 YKIITGKPS 243 K + PS Sbjct: 231 EKNRSLMPS 239 >5XZW-A nrPDB Length = 471 Score = 231 bits (589), Expect = 1e-60, Method: Composition-based stats. Identities = 73/282 (25%), Positives = 125/282 (44%), Gaps = 20/282 (7%) Query: 10 LLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVK 69 ++ +++GQGA A V + + TG FA+K+ + + +D RE EVL+KLNH IV+ Sbjct: 199 IIDEVVGQGAFATVKKAIERTTGKTFAVKIISKRKVIGNMDGVTRELEVLQKLNHPRIVR 258 Query: 70 LFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN 129 L E+T + ++MEF G L + + E + R ++ + ++ Sbjct: 259 LKGFYEDTESY--YMVMEFVSGGDLMDFVAAHG---AVGEDAGREISRQILTAIKYIHSM 313 Query: 130 GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAV 189 GI HRD+KP NI+ I +D + K+TDFG A+ + + GT Y+ P++ Sbjct: 314 GISHRDLKPDNIL--IEQDDPVLVKITDFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKD 371 Query: 190 LRKDHQKK-----YGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITG---K 241 + Y + VD+WS+G Y TG LPF ++ +I G + Sbjct: 372 TSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSG----STQDQLYKQIGRGSYHE 427 Query: 242 PSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLAN 283 + + ID + + S + L P + + Sbjct: 428 GPLKDFRISEEARDFIDSLLQV-DPNNRSTAAKALNHPWIVD 468 >4CFF-A nrPDB Length = 571 Score = 231 bits (588), Expect = 1e-60, Method: Composition-based stats. Identities = 64/234 (27%), Positives = 104/234 (44%), Gaps = 22/234 (9%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFN--NISFLRPVDVQMREFEVLKKLNHKN 66 ++L D LG G V G H+ TG A+K+ N I L V RE + LK H + Sbjct: 35 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 94 Query: 67 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 126 I+KL+ + T ++ME+ G L+ + + + E E + + ++ +++ Sbjct: 95 IIKLYQVISTPTD--FFMVMEYVSGGELFDYICKHGR---VEEMEARRLFQQILSAVDYC 149 Query: 127 RENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYE 186 + +VHRD+KP N++ D K+ DFG + + D E + G+ Y P++ Sbjct: 150 HRHMVVHRDLKPENVLL----DAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVIS 205 Query: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITG 240 + G VD+WS GV Y G+LPF P + KI G Sbjct: 206 GRLYA-------GPEVDIWSCGVILYALLCGTLPFDDEHVPT----LFKKIRGG 248 >4REW-A nrPDB Length = 540 Score = 230 bits (586), Expect = 2e-60, Method: Composition-based stats. Identities = 64/227 (28%), Positives = 106/227 (46%), Gaps = 18/227 (7%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFN--NISFLRPVDVQMREFEVLKKLNHKN 66 ++L D LG G V G+H+ TG A+K+ N I L V RE + LK H + Sbjct: 8 YILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPH 67 Query: 67 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 126 I+KL+ + +T ++ME+ G L+ + + L E E + + ++ G+++ Sbjct: 68 IIKLYQVI--STPSDIFMVMEYVSGGELFDYICKNGR---LDEKESRRLFQQILSGVDYC 122 Query: 127 RENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYE 186 + +VHRD+KP N++ D K+ DFG + + D E + G+ Y P++ Sbjct: 123 HRHMVVHRDLKPENVLL----DAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVIS 178 Query: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEV 233 + G VD+WS GV Y G+LPF P K++ Sbjct: 179 GRLYA-------GPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKI 218 >5EZV-A nrPDB Length = 560 Score = 229 bits (585), Expect = 3e-60, Method: Composition-based stats. Identities = 64/234 (27%), Positives = 104/234 (44%), Gaps = 22/234 (9%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFN--NISFLRPVDVQMREFEVLKKLNHKN 66 ++L D LG G V G H+ TG A+K+ N I L V RE + LK H + Sbjct: 30 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 89 Query: 67 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 126 I+KL+ + T ++ME+ G L+ + + + E E + + ++ +++ Sbjct: 90 IIKLYQVISTPTD--FFMVMEYVSGGELFDYICKHGR---VEEMEARRLFQQILSAVDYC 144 Query: 127 RENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYE 186 + +VHRD+KP N++ D K+ DFG + + D E + G+ Y P++ Sbjct: 145 HRHMVVHRDLKPENVLL----DAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVIS 200 Query: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITG 240 + G VD+WS GV Y G+LPF P + KI G Sbjct: 201 GRLYA-------GPEVDIWSCGVILYALLCGTLPFDDEHVPT----LFKKIRGG 243 >4RED-A nrPDB Length = 351 Score = 229 bits (583), Expect = 5e-60, Method: Composition-based stats. Identities = 64/227 (28%), Positives = 106/227 (46%), Gaps = 18/227 (7%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFN--NISFLRPVDVQMREFEVLKKLNHKN 66 ++L D LG G V G+H+ TG A+K+ N I L V RE + LK H + Sbjct: 16 YILGDTLGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPH 75 Query: 67 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 126 I+KL+ + +T ++ME+ G L+ + + L E E + + ++ G+++ Sbjct: 76 IIKLYQVI--STPSDIFMVMEYVSGGELFDYICKNGR---LDEKESRRLFQQILSGVDYC 130 Query: 127 RENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYE 186 + +VHRD+KP N++ D K+ DFG + + D E + G+ Y P++ Sbjct: 131 HRHMVVHRDLKPENVLL----DAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVIS 186 Query: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEV 233 + G VD+WS GV Y G+LPF P K++ Sbjct: 187 GRLYA-------GPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKI 226 >2JC6-A nrPDB Length = 334 Score = 229 bits (583), Expect = 5e-60, Method: Composition-based stats. Identities = 74/294 (25%), Positives = 120/294 (40%), Gaps = 39/294 (13%) Query: 4 TSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLN 63 ++ + LG GA + V K TG LFA+K + E VL+K+ Sbjct: 19 DIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIK 78 Query: 64 HKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 123 H+NIV L I E H L+M+ G L+ + E E + ++R V+ + Sbjct: 79 HENIVALEDIYESPN--HLYLVMQLVSGGELFDRIVEKG---FYTEKDASTLIRQVLDAV 133 Query: 124 NHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPD 183 +L GIVHRD+KP N + +D +S ++DFG ++ + + GT Y+ P+ Sbjct: 134 YYLHRMGIVHRDLKPEN-LLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPE 192 Query: 184 MYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS 243 + QK Y VD WSIGV Y G PF + ++ +I+ Sbjct: 193 VLA--------QKPYSKAVDCWSIGVIAYILLCGYPPFY----DENDSKLFEQILK---- 236 Query: 244 GAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQ 297 ++ D P +S + + N++E D K + +Q Sbjct: 237 -------------AEYEFDSPYWDDISDSAKDF----IRNLMEKDPNKRYTCEQ 273 >2YZA-A nrPDB Length = 276 Score = 228 bits (581), Expect = 9e-60, Method: Composition-based stats. Identities = 64/234 (27%), Positives = 103/234 (44%), Gaps = 22/234 (9%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFN--NISFLRPVDVQMREFEVLKKLNHKN 66 ++L D LG G V G H+ TG A+K+ N I L V RE + LK H + Sbjct: 13 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 72 Query: 67 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 126 I+KL+ + T ++ME+ G L+ + + + E E + + ++ +++ Sbjct: 73 IIKLYQVISTPTD--FFMVMEYVSGGELFDYICKHGR---VEEMEARRLFQQILSAVDYC 127 Query: 127 RENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYE 186 + +VHRD+KP N++ D K+ DFG + + D E G+ Y P++ Sbjct: 128 HRHMVVHRDLKPENVLL----DAHMNAKIADFGLSNMMSDGEFLRDSCGSPNYAAPEVIS 183 Query: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITG 240 + G VD+WS GV Y G+LPF P + KI G Sbjct: 184 GRLYA-------GPEVDIWSCGVILYALLCGTLPFDDEHVPT----LFKKIRGG 226 >2BDW-A nrPDB Length = 362 Score = 227 bits (579), Expect = 1e-59, Method: Composition-based stats. Identities = 65/232 (28%), Positives = 106/232 (45%), Gaps = 15/232 (6%) Query: 3 STSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFL-RPVDVQMREFEVLKK 61 + + + + + LG+GA + V R HK TG FA K+ N R RE + +K Sbjct: 25 TKFSDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRK 84 Query: 62 LNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVG 121 L H NIV+L +E + L+ + G L+ E+ E++ ++ ++ Sbjct: 85 LQHPNIVRLHDSIQEES--FHYLVFDLVTGGELF---EDIVAREFYSEADASHCIQQILE 139 Query: 122 GMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLH 181 + + NGIVHR++KP N++ G + KL DFG A E+ D E + GT YL Sbjct: 140 SIAYCHSNGIVHRNLKPENLLLASKAKGAA-VKLADFGLAIEVNDSEAWHGFAGTPGYLS 198 Query: 182 PDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEV 233 P++ + + Y VD+W+ GV Y G PF + R ++ Sbjct: 199 PEVLK--------KDPYSKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQI 242 >4CFH-A nrPDB Length = 493 Score = 227 bits (579), Expect = 1e-59, Method: Composition-based stats. Identities = 64/227 (28%), Positives = 106/227 (46%), Gaps = 18/227 (7%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFN--NISFLRPVDVQMREFEVLKKLNHKN 66 ++L D LG G V G+H+ TG A+K+ N I L V RE + LK H + Sbjct: 35 YILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPH 94 Query: 67 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 126 I+KL+ + +T ++ME+ G L+ + + L E E + + ++ G+++ Sbjct: 95 IIKLYQVI--STPSDIFMVMEYVSGGELFDYICKNGR---LDEKESRRLFQQILSGVDYC 149 Query: 127 RENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYE 186 + +VHRD+KP N++ D K+ DFG + + D E + G+ Y P++ Sbjct: 150 HRHMVVHRDLKPENVLL----DAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVIS 205 Query: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEV 233 + G VD+WS GV Y G+LPF P K++ Sbjct: 206 GRLYA-------GPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKI 245 >3F3Z-A nrPDB Length = 277 Score = 227 bits (579), Expect = 1e-59, Method: Composition-based stats. Identities = 73/272 (26%), Positives = 111/272 (40%), Gaps = 30/272 (11%) Query: 2 QSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKK 61 + N + L + +G+G+ V K T A K F+ VD +E E++K Sbjct: 4 KGDINQYYTLENTIGRGSWGEVKIAVQKGTRIRRAAKKIPKY-FVEDVDRFKQEIEIMKS 62 Query: 62 LNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVG 121 L+H NI++L+ E+ T L+ME C G L+ + ES+ +++DV+ Sbjct: 63 LDHPNIIRLYETFEDNTD--IYLVMELCTGGELFERVVHKR---VFRESDAARIMKDVLS 117 Query: 122 GMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLH 181 + + + + HRD+KP N + + KL DFG A + + + GT Y+ Sbjct: 118 AVAYCHKLNVAHRDLKPENFLFLTDSPDSP-LKLIDFGLAARFKPGKMMRTKVGTPYYVS 176 Query: 182 PDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 241 P + E YG D WS GV Y G PF + EVM KI G Sbjct: 177 PQVLEGL---------YGPECDEWSAGVMMYVLLCGYPPF----SAPTDSEVMLKIREGT 223 Query: 242 PSGAISGVQKAENGPIDWSGDMPVSCSLSRGL 273 + DW P + SL R L Sbjct: 224 FT----------FPEKDWLNVSPQAESLIRRL 245 >4RGJ-A nrPDB Length = 520 Score = 227 bits (578), Expect = 2e-59, Method: Composition-based stats. Identities = 71/278 (25%), Positives = 121/278 (43%), Gaps = 37/278 (13%) Query: 6 NHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLN 63 N + ILG+G+ V R K TG +AIKV + R D + +RE E+LK L+ Sbjct: 59 NEQYKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKESLLREVELLKMLD 118 Query: 64 HKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 123 H NI+KL+ E+ + L+ + G L+ E + E + +++ ++ G+ Sbjct: 119 HINIMKLYEFFEDNN--YYYLVSDVYTGGELFD---EIISRKRFYEIDAARIIKQILSGI 173 Query: 124 NHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPD 183 ++ +N +VHRD+KP NI+ + K+ DFG + E ++ GT Y+ PD Sbjct: 174 TYMHKNNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEYSKKMKDKIGTAYYIAPD 233 Query: 184 MYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS 243 + Y D+WS GV Y +G PF +++ K+ GK Sbjct: 234 VL---------HGTYDEKCDIWSCGVILYILLSGCPPF----NGSNEYDILKKVEAGK-- 278 Query: 244 GAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVL 281 ++ D+P +S + L+ +L Sbjct: 279 ---------------YTFDLPQFKKISDKAKDLIKKML 301 >3KK8-A nrPDB Length = 284 Score = 227 bits (578), Expect = 2e-59, Method: Composition-based stats. Identities = 65/232 (28%), Positives = 106/232 (45%), Gaps = 15/232 (6%) Query: 3 STSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFL-RPVDVQMREFEVLKK 61 + + + + + LG+GA + V R HK TG FA K+ N R RE + +K Sbjct: 2 TKFSDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRK 61 Query: 62 LNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVG 121 L H NIV+L +E + L+ + G L+ E+ E++ ++ ++ Sbjct: 62 LQHPNIVRLHDSIQEES--FHYLVFDLVTGGELF---EDIVAREFYSEADASHCIQQILE 116 Query: 122 GMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLH 181 + + NGIVHR++KP N++ G + KL DFG A E+ D E + GT YL Sbjct: 117 SIAYCHSNGIVHRNLKPENLLLASKAKGAA-VKLADFGLAIEVNDSEAWHGFAGTPGYLS 175 Query: 182 PDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEV 233 P++ + + Y VD+W+ GV Y G PF + R ++ Sbjct: 176 PEVLK--------KDPYSKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQI 219 >5IG1-A nrPDB Length = 344 Score = 226 bits (577), Expect = 2e-59, Method: Composition-based stats. Identities = 57/221 (25%), Positives = 99/221 (44%), Gaps = 15/221 (6%) Query: 14 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLR-PVDVQMREFEVLKKLNHKNIVKLFA 72 ++G+GA + V R +K+TG++ A+KV S ++ RE + L H++IV + Sbjct: 24 VIGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRSSEINKIKREIGICSSLQHEHIVSMRR 83 Query: 73 IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIV 132 + + H L+ E+ G L+ E E + + ++ + H I+ Sbjct: 84 AFRDES--HFYLVFEYVSGGELFD---EIVTRKFYNEKDASACMHQILSALQHCHSKNII 138 Query: 133 HRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRK 192 HRD+KP N++ +D + K+TDFG A +E + GT YL P++ R Sbjct: 139 HRDLKPENLLLA-SKDPNAPVKITDFGLAVIMEQGPTYFGFAGTPGYLSPEVIRRV---- 193 Query: 193 DHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEV 233 Y VD+W+ GV Y G PF + + ++ Sbjct: 194 ----PYDTAVDVWACGVILYILLVGYPPFWEEDHQKLYAQI 230 >3IS5-A nrPDB Length = 285 Score = 226 bits (575), Expect = 3e-59, Method: Composition-based stats. Identities = 74/293 (25%), Positives = 120/293 (40%), Gaps = 39/293 (13%) Query: 1 MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLK 60 Q T + L++ LG GA +V + +G IK N P++ E EVLK Sbjct: 16 FQGTIDDLFIFKRKLGSGAFGDVHLVEERSSGLERVIKTINKDRSQVPMEQIEAEIEVLK 75 Query: 61 KLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVL-EEPSNAYGLPESEFLIVLRDV 119 L+H NI+K+F + E+ + ++ME C G L + + L E +++ + Sbjct: 76 SLDHPNIIKIFEVFEDYH--NMYIVMETCEGGELLERIVSAQARGKALSEGYVAELMKQM 133 Query: 120 VGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEY 179 + + + +VH+D+KP NI+ S K+ DFG A + DE + GT Y Sbjct: 134 MNALAYFHSQHVVHKDLKPENILF-QDTSPHSPIKIIDFGLAELFKSDEHSTNAAGTALY 192 Query: 180 LHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIIT 239 + P++++R V D+WS GV Y TG LPF ++ YK Sbjct: 193 MAPEVFKRDV---------TFKCDIWSAGVVMYFLLTGCLPFTGTSLEEVQQKATYK--- 240 Query: 240 GKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKC 292 +P+ A+ R L +L +L D E+ Sbjct: 241 -EPNYAVE----------------------CRPLTPQAVDLLKQMLTKDPERR 270 >2J90-A nrPDB Length = 304 Score = 226 bits (575), Expect = 4e-59, Method: Composition-based stats. Identities = 74/285 (25%), Positives = 117/285 (41%), Gaps = 40/285 (14%) Query: 1 MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPV-----DVQMRE 55 QS + + + LG G A V + R K TG +A K + RE Sbjct: 20 FQSMVEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIERE 79 Query: 56 FEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIV 115 +L+++ H NI+ L I E T VLI+E G L+ L E + L E E Sbjct: 80 VNILREIRHPNIITLHDIFENKTD--VVLILELVSGGELFDFLAEKES---LTEDEATQF 134 Query: 116 LRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYG 175 L+ ++ G+++L I H D+KP NIM + KL DFG A ++E +F +++G Sbjct: 135 LKQILDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFG 194 Query: 176 TEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRN----- 230 T E++ P++ L G D+WSIGV Y +G+ PF Sbjct: 195 TPEFVAPEIVNYEPL--------GLEADMWSIGVITYILLSGASPFLGETKQETLTNISA 246 Query: 231 -----------------KEVMYKIITGKPSGAISGVQKAENGPID 258 K+ + +++ P ++ Q E+ I Sbjct: 247 VNYDFDEEYFSNTSELAKDFIRRLLVKDPKRRMTIAQSLEHSWIK 291 >5JZN-A nrPDB Length = 280 Score = 225 bits (573), Expect = 7e-59, Method: Composition-based stats. Identities = 65/240 (27%), Positives = 108/240 (45%), Gaps = 19/240 (7%) Query: 3 STSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKL 62 +T + + +G G A V + T +A+K+ + E +L+++ Sbjct: 15 ATITERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHMIQNEVSILRRV 74 Query: 63 NHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGG 122 H NIV L IEE L+ME G L+ + ++ E + +L ++ Sbjct: 75 KHPNIVLL--IEEMDVPTELYLVMELVKGGDLFDAI---TSTNKYTERDASGMLYNLASA 129 Query: 123 MNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHP 182 + +L IVHRDIKP N++ +DG KL DFG A + D ++ GT Y+ P Sbjct: 130 IKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIV--DGPLYTVCGTPTYVAP 187 Query: 183 DMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMY-KIITGK 241 ++ + YG VD+W+ GV Y G PFR G ++EV++ +I+ G+ Sbjct: 188 EIIA--------ETGYGLKVDIWAAGVITYILLCGFPPFR---GSGDDQEVLFDQILMGQ 236 >5FG8-A nrPDB Length = 285 Score = 224 bits (572), Expect = 8e-59, Method: Composition-based stats. Identities = 72/276 (26%), Positives = 125/276 (45%), Gaps = 38/276 (13%) Query: 6 NHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFL-RPVDVQMREFEVLKKLNH 64 + + + + LG+GA + V R K TG FA K+ N R RE + +KL+H Sbjct: 13 SDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHH 72 Query: 65 KNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 124 NIV+L +E + L+ + G L+ E+ E++ ++ ++ +N Sbjct: 73 PNIVRLHDSIQEEN--YHYLVFDLVTGGELF---EDIVAREFYSEADASHCIQQILESVN 127 Query: 125 HLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQ-FVSLYGTEEYLHPD 183 H +NG+VHRD+KP N++ G + KL DFG A E++ D Q + GT YL P+ Sbjct: 128 HCHQNGVVHRDLKPENLLLASKAKGAA-VKLADFGLAIEVQGDHQAWFGFAGTPGYLSPE 186 Query: 184 MYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF----------------RPFEGP 227 + + ++ YG +VD+W+ GV Y G PF + P Sbjct: 187 VLK--------KEPYGKSVDIWACGVILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSP 238 Query: 228 RRN------KEVMYKIITGKPSGAISGVQKAENGPI 257 + K ++ +++T P+ I+ + ++ I Sbjct: 239 EWDTVTPEAKNLINQMLTVNPNKRITAAEALKHPWI 274 >4FG9-A nrPDB Length = 320 Score = 224 bits (571), Expect = 1e-58, Method: Composition-based stats. Identities = 74/294 (25%), Positives = 117/294 (39%), Gaps = 39/294 (13%) Query: 4 TSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLN 63 ++ D+LG GA + V K+T L AIK + E VL K+ Sbjct: 15 DIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMENEIAVLHKIK 74 Query: 64 HKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 123 H NIV L I E H LIM+ G L+ + E E + ++ V+ + Sbjct: 75 HPNIVALDDIYESGG--HLYLIMQLVSGGELFDRIVEKG---FYTERDASRLIFQVLDAV 129 Query: 124 NHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPD 183 +L + GIVHRD+KP N + D S ++DFG ++ + + GT Y+ P+ Sbjct: 130 KYLHDLGIVHRDLKPEN-LLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPE 188 Query: 184 MYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS 243 + QK Y VD WSIGV Y G PF + ++ +I+ Sbjct: 189 VLA--------QKPYSKAVDCWSIGVIAYILLCGYPPFY----DENDAKLFEQILK---- 232 Query: 244 GAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQ 297 ++ D P +S + + +++E D EK + +Q Sbjct: 233 -------------AEYEFDSPYWDDISDSAKDF----IRHLMEKDPEKRFTCEQ 269 >4CSV-A nrPDB Length = 275 Score = 223 bits (568), Expect = 2e-58, Method: Composition-based stats. Identities = 56/281 (19%), Positives = 107/281 (38%), Gaps = 23/281 (8%) Query: 4 TSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLN 63 L LG G V+ G+ + A+K + V+ ++E +++KKL Sbjct: 8 IPRSEITLERKLGSGQFGEVYEGKWRNYNIEVAVKTLKEGTM--SVEEFLQEAQIMKKLK 65 Query: 64 HKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 123 H N+V+L+ + + +I E+ GSL L + + + L + V GM Sbjct: 66 HPNLVQLYGVCTKEPP--IYIITEYMSHGSLLDYLRD-CEGHTVNAQALLDMAAQVASGM 122 Query: 124 NHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTE---EYL 180 +L +HRD+ N + V K+ DFG AR + +DE + + G + ++ Sbjct: 123 AYLESQNFIHRDLAARNCLVGENN----VVKVADFGLARLINEDE-YTARAGAKFPIKWT 177 Query: 181 HPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVMYKIIT 239 P+ ++ D+W+ G+ + T G +P+ G ++V Sbjct: 178 APEAIS--------YNRFSIKSDVWAFGILLWEIFTYGQVPYPGMSGSEVIEQVERGYRM 229 Query: 240 GKPSGAISGVQK-AENGPIDWSGDMPVSCSLSRGLQVLLTP 279 +P G + + + P L+ + P Sbjct: 230 PRPQGCPEEIYELMLQCWNKSPEERPTFAETLHALETMFLP 270 >2JAM-A nrPDB Length = 304 Score = 222 bits (567), Expect = 3e-58, Method: Composition-based stats. Identities = 79/241 (32%), Positives = 120/241 (49%), Gaps = 21/241 (8%) Query: 1 MQSTS-NHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVL 59 MQ+T+ ++ ++LG GA + VF + + TG LFA+K R ++ E VL Sbjct: 2 MQTTNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSSLE-NEIAVL 60 Query: 60 KKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDV 119 KK+ H+NIV L I E TT H L+M+ G L+ + E E + +V++ V Sbjct: 61 KKIKHENIVTLEDIYESTT--HYYLVMQLVSGGELFDRILERG---VYTEKDASLVIQQV 115 Query: 120 VGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEY 179 + + +L ENGIVHRD+KP N++ + E+ S +TDFG ++ +E + + GT Y Sbjct: 116 LSAVKYLHENGIVHRDLKPENLLYLTPEE-NSKIMITDFGLSK-MEQNGIMSTACGTPGY 173 Query: 180 LHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIIT 239 + P++ QK Y VD WSIGV Y G PF ++ KI Sbjct: 174 VAPEVLA--------QKPYSKAVDCWSIGVITYILLCGYPPFYE----ETESKLFEKIKE 221 Query: 240 G 240 G Sbjct: 222 G 222 >3MN3-A nrPDB Length = 271 Score = 221 bits (563), Expect = 9e-58, Method: Composition-based stats. Identities = 50/215 (23%), Positives = 90/215 (41%), Gaps = 19/215 (8%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRP--VDVQMREFEVLKKLNHKN 66 + + LG+G+ V H TG A+K+ N + RE L+ L H + Sbjct: 6 YQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRHPH 65 Query: 67 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 126 I+KL+ + + ++++E+ L+ + + + E E + ++ + + Sbjct: 66 IIKLYDVI--KSKDEIIMVIEYA-GNELFDYIVQRDK---MSEQEARRFFQQIISAVEYC 119 Query: 127 RENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYE 186 + IVHRD+KP N++ D K+ DFG + + D + G+ Y P++ Sbjct: 120 HRHKIVHRDLKPENLLL----DEHLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVIS 175 Query: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 + G VD+WS GV Y LPF Sbjct: 176 GKLYA-------GPEVDVWSCGVILYVMLCRRLPF 203 >4PDS-A nrPDB Length = 347 Score = 221 bits (563), Expect = 9e-58, Method: Composition-based stats. Identities = 71/280 (25%), Positives = 123/280 (43%), Gaps = 20/280 (7%) Query: 10 LLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVK 69 ++ +++GQGA A V + + TG F++K+ + + +D RE EVL+KLNH IV+ Sbjct: 34 IIDEVVGQGAFATVKKAIERTTGKTFSVKIISKRKVIGNMDGVTRELEVLQKLNHPRIVR 93 Query: 70 LFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN 129 L E+T + ++MEF G L + + E + R ++ + ++ Sbjct: 94 LKGFYEDTESY--YMVMEFVSGGDLMDFVAAHG---AVGEDAGREISRQILTAIKYIHSM 148 Query: 130 GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAV 189 GI HRD+KP NI+ I +D + K+T FG A+ + + GT Y+ P++ Sbjct: 149 GISHRDLKPDNIL--IEQDDPVLVKITAFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKD 206 Query: 190 LRKDHQKK-----YGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITG---K 241 + Y + VD+WS+G Y TG LPF ++ +I G + Sbjct: 207 TSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSG----STQDQLYKQIGRGSYHE 262 Query: 242 PSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVL 281 + + ID + + S + L P + Sbjct: 263 GPLKDFRISEEARDFIDSLLQV-DPNNRSTAAKALNHPWI 301 >4D28-A nrPDB Length = 446 Score = 221 bits (562), Expect = 1e-57, Method: Composition-based stats. Identities = 65/279 (23%), Positives = 115/279 (41%), Gaps = 38/279 (13%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRP--VDVQMREFEVLKKLNHKN 66 + + +G+G A V R+ TGD AIK+ + L+ VD RE ++K + H N Sbjct: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 Query: 67 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 126 IV+L+ + + +++EF G L+ + L E E + +V + H Sbjct: 71 IVRLYEVLASKSK--IYIVLEFVTGGELFDRIVHKGR---LKEDESRKYFQQLVDAVAHC 125 Query: 127 RENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD-EQFVSLYGTEEYLHPDMY 185 G+ HRD+KP N++ D K++DFG + ++ E GT Y+ P++ Sbjct: 126 HSKGVYHRDLKPENLLL----DTNGNLKVSDFGLSALPQEGVELLNDTCGTPNYVAPEVL 181 Query: 186 ERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEV------------ 233 G+ D+WS GV + G LPF + P +++ Sbjct: 182 SGQGYD-------GSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFDCPPWFS 234 Query: 234 ------MYKIITGKPSGAISGVQKAENGPIDWSGDMPVS 266 +++I+ P I +Q + P +P+ Sbjct: 235 AEVKFLIHRILDPNPKTRI-QIQGIKKDPWFRKNYVPIR 272 >4CZT-A nrPDB Length = 464 Score = 220 bits (561), Expect = 1e-57, Method: Composition-based stats. Identities = 68/282 (24%), Positives = 117/282 (41%), Gaps = 41/282 (14%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHKN 66 + L LG+G A V R+ + GD AIKV + L+ + RE +K + H N Sbjct: 13 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 72 Query: 67 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 126 ++++F + T ++EF G L+ + S+ L E E + ++ +++ Sbjct: 73 VIRMFEVMASKTK--IYFVLEFVTGGELFD---KISSNGRLKEDEARKYFQQLINAVDYC 127 Query: 127 RENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAAR---ELEDDEQFVSLYGTEEYLHPD 183 G+ HRD+KP N++ D K++DFG + ++ +D + GT Y+ P+ Sbjct: 128 HSRGVYHRDLKPENLLL----DANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPE 183 Query: 184 MYERAVLRKDHQKKY-GATVDLWSIGVTFYHAATGSLPFR------------------PF 224 + + K Y GA DLWS GV + G LPF P Sbjct: 184 VI--------NNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPP 235 Query: 225 EGPRRNKEVMYKIITGKPSGAISGVQKAENGPIDWSGDMPVS 266 K+++ +I+ P+ I+ + EN P Sbjct: 236 WFSASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKAPKF 277 >2YCR-A nrPDB Length = 323 Score = 219 bits (559), Expect = 2e-57, Method: Composition-based stats. Identities = 68/243 (27%), Positives = 109/243 (44%), Gaps = 22/243 (9%) Query: 6 NHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFL----RPVDVQMR---EFEV 58 +++S LG GA V +KT AIK+ + F R D + E E+ Sbjct: 9 RDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEI 68 Query: 59 LKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRD 118 LKKLNH I+K+ + +++E G L+ + L E+ + Sbjct: 69 LKKLNHPCIIKIKNFFDAED---YYIVLELMEGGELFD---KVVGNKRLKEATCKLYFYQ 122 Query: 119 VVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEE 178 ++ + +L ENGI+HRD+KP N++ E+ + K+TDFG ++ L + +L GT Sbjct: 123 MLLAVQYLHENGIIHRDLKPENVLLSSQEE-DCLIKITDFGHSKILGETSLMRTLCGTPT 181 Query: 179 YLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKII 238 YL P++ L Y VD WS+GV + +G PF K+ +I Sbjct: 182 YLAPEV-----LVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKD---QIT 233 Query: 239 TGK 241 +GK Sbjct: 234 SGK 236 >3H4J-B nrPDB Length = 336 Score = 219 bits (559), Expect = 3e-57, Method: Composition-based stats. Identities = 59/237 (24%), Positives = 101/237 (42%), Gaps = 21/237 (8%) Query: 1 MQSTSNHL--WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQM--REF 56 M + H+ +++ + LG+G+ V H KT A+K + + RE Sbjct: 1 MAISKRHIGPYIIRETLGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREI 60 Query: 57 EVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVL 116 LK L H +I+KL+ + T V+++E+ G L+ + E + E E Sbjct: 61 SYLKLLRHPHIIKLYDVITTPTD--IVMVIEYA-GGELFDYIVEKKR---MTEDEGRRFF 114 Query: 117 RDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGT 176 + ++ + + + IVHRD+KP N++ D K+ DFG + + D + G+ Sbjct: 115 QQIICAIEYCHRHKIVHRDLKPENLLL----DDNLNVKIADFGLSNIMTDGNFLKTSCGS 170 Query: 177 EEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEV 233 Y P++ + G VD+WS G+ Y G LPF P K+V Sbjct: 171 PNYAAPEVINGKLYA-------GPEVDVWSCGIVLYVMLVGRLPFDDEFIPNLFKKV 220 >3UC3-A nrPDB Length = 361 Score = 219 bits (559), Expect = 3e-57, Method: Composition-based stats. Identities = 61/236 (25%), Positives = 97/236 (41%), Gaps = 16/236 (6%) Query: 6 NHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHK 65 + + +G G R K T +L A+K + + + RE + L H Sbjct: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGAAID--ENVQREIINHRSLRHP 76 Query: 66 NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 125 NIV+ + T H +IME+ G LY + NA E E + ++ G+++ Sbjct: 77 NIVRFKEVILTPT--HLAIIMEYASGGELYERI---CNAGRFSEDEARFFFQQLLSGVSY 131 Query: 126 LRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMY 185 I HRD+K N + K+ DFG ++ Q S GT Y+ P++ Sbjct: 132 CHSMQICHRDLKLENTLL--DGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVL 189 Query: 186 ERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 241 R G D+WS GVT Y G+ PF E PR ++ + +I++ K Sbjct: 190 LRQEYD-------GKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVK 238 >4YZB-A nrPDB Length = 491 Score = 219 bits (558), Expect = 4e-57, Method: Composition-based stats. Identities = 64/282 (22%), Positives = 119/282 (42%), Gaps = 38/282 (13%) Query: 3 STSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKL 62 + + + +LG+G+ V + K TG +A+KV + + D ++ EV Sbjct: 26 AAFSDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDKELLLKEVELLK 85 Query: 63 --NHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVV 120 +H NI+KL+ E+ + L+ E G L+ E + E + ++R V+ Sbjct: 86 KLDHPNIMKLYEFFED--KGYFYLVTEVYTGGELFD---EIISRKRFSEVDAARIIRQVL 140 Query: 121 GGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYL 180 G+ ++ +N IVHRD+KP N++ + + ++ DFG + E ++ GT Y+ Sbjct: 141 SGITYMHKNKIVHRDLKPENLLLE-NKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYI 199 Query: 181 HPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITG 240 P++ Y D+WS GV Y +G PF +++ K+ G Sbjct: 200 APEVL---------HGTYDEKCDVWSTGVILYILLSGCPPF----NGANEFDILKKVEKG 246 Query: 241 KPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLA 282 K ++ D+P +S + L+ +LA Sbjct: 247 K-----------------FTFDLPQWKKVSEPAKDLIRKMLA 271 >2BPM-A nrPDB Length = 309 Score = 219 bits (557), Expect = 5e-57, Method: Composition-based stats. Identities = 65/285 (22%), Positives = 107/285 (37%), Gaps = 17/285 (5%) Query: 12 SDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPV-DVQMREFEVLKKLNHKNIVKL 70 + +G+G V++ R+K TG++ A+K + V +RE +LK+LNH NIVKL Sbjct: 12 VEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKL 71 Query: 71 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 130 + T L+ EF L ++ S G+P L ++ G+ + Sbjct: 72 LDVIH--TENKLYLVFEFL-HQDLKKFMDA-SALTGIPLPLIKSYLFQLLQGLAFCHSHR 127 Query: 131 IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELE-DDEQFVSLYGTEEYLHPDMYERAV 189 ++HRD+KP N++ + + KL DFG AR + T Y P++ Sbjct: 128 VLHRDLKPQNLLI----NTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGC- 182 Query: 190 LRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGV 249 K Y VD+WS+G F T F + + + T Sbjct: 183 ------KYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVT 236 Query: 250 QKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWG 294 + P + L +L+ +L D K Sbjct: 237 SMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS 281 >3I6U-A nrPDB Length = 419 Score = 218 bits (556), Expect = 6e-57, Method: Composition-based stats. Identities = 67/243 (27%), Positives = 109/243 (44%), Gaps = 22/243 (9%) Query: 6 NHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFL----RPVDVQMR---EFEV 58 +++S LG GA V +KT AI++ + F R D + E E+ Sbjct: 134 RDEYIMSKTLGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADPALNVETEIEI 193 Query: 59 LKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRD 118 LKKLNH I+K+ + +++E G L+ + L E+ + Sbjct: 194 LKKLNHPCIIKIKNFFDAED---YYIVLELMEGGELFD---KVVGNKRLKEATCKLYFYQ 247 Query: 119 VVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEE 178 ++ + +L ENGI+HRD+KP N++ E+ + K+TDFG ++ L + +L GT Sbjct: 248 MLLAVQYLHENGIIHRDLKPENVLLSSQEE-DCLIKITDFGHSKILGETSLMRTLCGTPT 306 Query: 179 YLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKII 238 YL P++ L Y VD WS+GV + +G PF K+ +I Sbjct: 307 YLAPEV-----LVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKD---QIT 358 Query: 239 TGK 241 +GK Sbjct: 359 SGK 361 >2VN9-A nrPDB Length = 301 Score = 218 bits (555), Expect = 7e-57, Method: Composition-based stats. Identities = 73/273 (26%), Positives = 117/273 (42%), Gaps = 38/273 (13%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFL-RPVDVQMREFEVLKKLNHKNI 67 + L + LG+GA + V R TG +A K+ N R RE + + L H NI Sbjct: 6 YQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 65 Query: 68 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 127 V+L E L+ + G L+ E+ E++ ++ ++ +NH Sbjct: 66 VRLHDSISEEG--FHYLVFDLVTGGELF---EDIVAREYYSEADASHCIQQILESVNHCH 120 Query: 128 ENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQ-FVSLYGTEEYLHPDMYE 186 NGIVHRD+KP N++ G + KL DFG A E++ D+Q + GT YL P++ Sbjct: 121 LNGIVHRDLKPENLLLASKSKGAA-VKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLR 179 Query: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF----------------RPFEGPRRN 230 + YG VD+W+ GV Y G PF F P + Sbjct: 180 --------KDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWD 231 Query: 231 ------KEVMYKIITGKPSGAISGVQKAENGPI 257 K+++ K++T P+ I+ + ++ I Sbjct: 232 TVTPEAKDLINKMLTINPAKRITASEALKHPWI 264 >6E9W-A nrPDB Length = 443 Score = 218 bits (555), Expect = 7e-57, Method: Composition-based stats. Identities = 56/238 (23%), Positives = 104/238 (43%), Gaps = 18/238 (7%) Query: 3 STSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQM--REFEVLK 60 + + ++G+GA V RHK T ++A+K+ + ++ D E +++ Sbjct: 98 RMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMA 157 Query: 61 KLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVV 120 N +V+LF ++ R+ ++ME+ P G L ++ + Y +PE +VV Sbjct: 158 FANSPWVVQLFYAFQD--DRYLYMVMEYMPGGDLVNLM----SNYDVPEKWARFYTAEVV 211 Query: 121 GGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFV--SLYGTEE 178 ++ + G +HRD+KP N++ D KL DFG ++ + + GT + Sbjct: 212 LALDAIHSMGFIHRDVKPDNMLL----DKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPD 267 Query: 179 YLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYK 236 Y+ P++ + + YG D WS+GV Y G PF ++M Sbjct: 268 YISPEVLK----SQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNH 321 >6HXF-B nrPDB Length = 302 Score = 218 bits (555), Expect = 8e-57, Method: Composition-based stats. Identities = 73/285 (25%), Positives = 124/285 (43%), Gaps = 25/285 (8%) Query: 4 TSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLN 63 N +W + LG GA V++ ++K+TG L A KV ++ + E E+L + Sbjct: 16 DPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVI-ETKSEEELEDYIVEIEILATCD 74 Query: 64 HKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 123 H IVKL +++EFCP G++ ++ E GL E + +V R ++ + Sbjct: 75 HPYIVKLLGAYY--HDGKLWIMIEFCPGGAVDAIMLELDR--GLTEPQIQVVCRQMLEAL 130 Query: 124 NHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFG-AARELEDDEQFVSLYGTEEYLHP 182 N L I+HRD+K GN++ + D +L DFG +A+ L+ ++ S GT ++ P Sbjct: 131 NFLHSKRIIHRDLKAGNVLMTLEGD----IRLADFGVSAKNLKTLQKRDSFIGTPYWMAP 186 Query: 183 DMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKP 242 ++ ++ Y D+WS+G+T A P R V+ KI P Sbjct: 187 EVVMCETMK---DTPYDYKADIWSLGITLIEMAQIEPPHHELNPMR----VLLKIAKSDP 239 Query: 243 SGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEA 287 ++ P WS + ++ P A +LE Sbjct: 240 PTLLT--------PSKWSVEFRDFLKIALDKNPETRPSAAQLLEH 276 >2Z7Q-A nrPDB Length = 321 Score = 217 bits (554), Expect = 1e-56, Method: Composition-based stats. Identities = 75/245 (30%), Positives = 120/245 (48%), Gaps = 27/245 (11%) Query: 2 QSTSNHLWLLSDILGQGATANVFRGRHK---KTGDLFAIKVFNNISFL-RPVDVQMREFE 57 ++ +H LL +LGQG+ VF R +G L+A+KV + R E + Sbjct: 24 KADPSHFELL-KVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERD 82 Query: 58 VLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLR 117 +L +NH +VKL + T LI++F G L+T L + E + L Sbjct: 83 ILADVNHPFVVKLHYAFQ--TEGKLYLILDFLRGGDLFTRLSKE---VMFTEEDVKFYLA 137 Query: 118 DVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARE-LEDDEQFVSLYGT 176 ++ G++HL GI++RD+KP NI+ D + KLTDFG ++E ++ +++ S GT Sbjct: 138 ELALGLDHLHSLGIIYRDLKPENILL----DEEGHIKLTDFGLSKEAIDHEKKAYSFCGT 193 Query: 177 EEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYK 236 EY+ P++ R + + + D WS GV + TGSLPF+ + KE M Sbjct: 194 VEYMAPEVVNR--------QGHSHSADWWSYGVLMFEMLTGSLPFQG----KDRKETMTL 241 Query: 237 IITGK 241 I+ K Sbjct: 242 ILKAK 246 >5YKS-A nrPDB Length = 377 Score = 217 bits (553), Expect = 1e-56, Method: Composition-based stats. Identities = 61/280 (21%), Positives = 113/280 (40%), Gaps = 33/280 (11%) Query: 8 LWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLR-PVDVQMREFEVLKKLNHKN 66 L+ L LG+G A V RH TG+ A+KV + +E +K + H N Sbjct: 36 LYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHPN 95 Query: 67 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 126 IV+L+ + + T LI+E G ++ + + GL E +V +++ Sbjct: 96 IVRLYEVIDTQTK--LYLILELGDGGDMFDYI--MKHEEGLNEDLAKKYFAQIVHAISYC 151 Query: 127 RENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYE 186 + +VHRD+KP N++ + Q + KLTDFG + + + ++ + G+ Y P++ Sbjct: 152 HKLHVVHRDLKPENVVFF---EKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILL 208 Query: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFR------------------PFEGPR 228 VD+WS+GV + G PF+ P + Sbjct: 209 GDEYDA-------PAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSK 261 Query: 229 RNKEVMYKIITGKPSGAISGVQKAENGPIDWSGDMPVSCS 268 K+++ +++ P S + + + P + Sbjct: 262 ECKDLITRMLQRDPKRRASLEEIENHPWLQGVDPSPATKY 301 >3TAC-A nrPDB Length = 361 Score = 217 bits (553), Expect = 1e-56, Method: Composition-based stats. Identities = 61/272 (22%), Positives = 115/272 (42%), Gaps = 32/272 (11%) Query: 6 NHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRP----VDVQMREFEVLKK 61 ++ L +++G+G + V R +++TG FA+K+ + F + RE + Sbjct: 25 EDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHM 84 Query: 62 LNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSL-YTVLEEPSNAYGLPESEFLIVLRDVV 120 L H +IV+L ++ ++ EF L + +++ + E+ +R ++ Sbjct: 85 LKHPHIVELLETY--SSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQIL 142 Query: 121 GGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFV-SLYGTEEY 179 + + +N I+HRD+KP ++ E+ KL FG A +L + GT + Sbjct: 143 EALRYCHDNNIIHRDVKPHCVLLASKENSAP-VKLGGFGVAIQLGESGLVAGGRVGTPHF 201 Query: 180 LHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIIT 239 + P++ +R + YG VD+W GV + +G LPF + + + II Sbjct: 202 MAPEVVKR--------EPYGKPVDVWGCGVILFILLSGCLPFYGTK-----ERLFEGIIK 248 Query: 240 GKPSGAISGVQKAENGPIDWSGDMPVSCSLSR 271 GK + P WS + L R Sbjct: 249 GK----------YKMNPRQWSHISESAKDLVR 270 >2W4O-A nrPDB Length = 349 Score = 217 bits (552), Expect = 2e-56, Method: Composition-based stats. Identities = 65/233 (27%), Positives = 110/233 (47%), Gaps = 20/233 (8%) Query: 6 NHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHK 65 + + + LG+GAT+ V+R + K T +A+KV + + E VL +L+H Sbjct: 52 SDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKK---IVRTEIGVLLRLSHP 108 Query: 66 NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 125 NI+KL I E T L++E G L+ + E E + ++ ++ + + Sbjct: 109 NIIKLKEIFETPT--EISLVLELVTGGELFDRIVEKG---YYSERDAADAVKQILEAVAY 163 Query: 126 LRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMY 185 L ENGIVHRD+KP N++ + K+ DFG ++ +E ++ GT Y P++ Sbjct: 164 LHENGIVHRDLKPENLLYATPA-PDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEIL 222 Query: 186 ERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKII 238 YG VD+WS+G+ Y G F PF R ++ + +I+ Sbjct: 223 RGCA--------YGPEVDMWSVGIITYILLCG---FEPFYDERGDQFMFRRIL 264 >2YAB-A nrPDB Length = 361 Score = 216 bits (551), Expect = 2e-56, Method: Composition-based stats. Identities = 68/225 (30%), Positives = 104/225 (46%), Gaps = 18/225 (8%) Query: 2 QSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPV-----DVQMREF 56 Q + + + LG G A V + R K TG +A K + RE Sbjct: 7 QQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIEREV 66 Query: 57 EVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVL 116 +L+++ H NI+ L + E T VLI+E G L+ L + + L E E + Sbjct: 67 SILRQVLHPNIITLHDVYENRTD--VVLILELVSGGELFDFLAQKES---LSEEEATSFI 121 Query: 117 RDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGT 176 + ++ G+N+L I H D+KP NIM + KL DFG A E+ED +F +++GT Sbjct: 122 KQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGT 181 Query: 177 EEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 E++ P++ L G D+WSIGV Y +G+ PF Sbjct: 182 PEFVAPEIVNYEPL--------GLEADMWSIGVITYILLSGASPF 218 >3HDN-A nrPDB Length = 373 Score = 216 bits (551), Expect = 2e-56, Method: Composition-based stats. Identities = 74/322 (22%), Positives = 121/322 (37%), Gaps = 61/322 (18%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVL-KKLNHK 65 + ++G+G+ V RHK +A+KV + L+ + + M E VL K + H Sbjct: 40 FHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHP 99 Query: 66 NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 125 +V L T ++++ G L+ L+ E ++ + + Sbjct: 100 FLVGLH--FSFQTADKLYFVLDYINGGELFYHLQRERC---FLEPRARFYAAEIASALGY 154 Query: 126 LRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARE-LEDDEQFVSLYGTEEYLHPDM 184 L IV+RD+KP NI+ D Q LTDFG +E +E + + GT EYL P++ Sbjct: 155 LHSLNIVYRDLKPENILL----DSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEV 210 Query: 185 YERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSG 244 H++ Y TVD W +G Y G PF RN MY I KP Sbjct: 211 L--------HKQPYDRTVDWWCLGAVLYEMLYGLPPFY-----SRNTAEMYDNILNKPLQ 257 Query: 245 AISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFAET-- 302 + + +L +L+ D+ K G F E Sbjct: 258 LKPNITNSAR------------------------HLLEGLLQKDRTKRLGAKDDFMEIKS 293 Query: 303 ---------SDILHRMVIHVFS 315 D++++ + F+ Sbjct: 294 HVFFSLINWDDLINKKITPPFN 315 >3NIZ-A nrPDB Length = 311 Score = 216 bits (551), Expect = 2e-56, Method: Composition-based stats. Identities = 76/312 (24%), Positives = 124/312 (39%), Gaps = 28/312 (8%) Query: 1 MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPV-DVQMREFEVL 59 Q L + G+G V++ + + G + A+K + + +RE +L Sbjct: 16 FQGLMEKYQKLEKV-GEGTYGVVYKAKDSQ-GRIVALKRIRLDAEDEGIPSTAIREISLL 73 Query: 60 KKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDV 119 K+L+H NIV L + + R L+ EF L VL+E N GL +S+ I L + Sbjct: 74 KELHHPNIVSLIDVIH--SERCLTLVFEFMEK-DLKKVLDE--NKTGLQDSQIKIYLYQL 128 Query: 120 VGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELE-DDEQFVSLYGTEE 178 + G+ H ++ I+HRD+KP N++ + KL DFG AR + T Sbjct: 129 LRGVAHCHQHRILHRDLKPQNLLI----NSDGALKLADFGLARAFGIPVRSYTHEVVTLW 184 Query: 179 YLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKII 238 Y PD+ + KKY +VD+WSIG F TG F + ++ + Sbjct: 185 YRAPDVLMGS-------KKYSTSVDIWSIGCIFAEMITGKPLFPGVTDDDQLPKIFSILG 237 Query: 239 TGKPS--GAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFD 296 T P + + + P S + Q +L+N+L D K Sbjct: 238 TPNPREWPQVQELPLWKQRTFQVFEKKPWSSIIPGFCQE-GIDLLSNMLCFDPNKRISAR 296 Query: 297 Q-----FFAETS 303 +F + Sbjct: 297 DAMNHPYFKDLD 308 >5WAX-A nrPDB Length = 310 Score = 216 bits (550), Expect = 3e-56, Method: Composition-based stats. Identities = 55/235 (23%), Positives = 97/235 (41%), Gaps = 18/235 (7%) Query: 6 NHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHK 65 + L +G G R++ G L A+K + + RE + L H Sbjct: 10 GDRYELVRDIGSGNFGVARLMRNRADGQLVAVKYIERGEKID--ENVQREIINHRSLRHP 67 Query: 66 NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 125 NI++ + T H ++ME+ G L+ + NA E E + ++ G+++ Sbjct: 68 NIIRFKEVILTPT--HLAIVMEYASGGELFERI---CNAGRFSEDEARFFFQQLISGVSY 122 Query: 126 LRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMY 185 + HRD+K N + K+ DFG ++ Q S GT Y+ P++ Sbjct: 123 CHSMQVCHRDLKLENTLL--DGSTAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVL 180 Query: 186 ERAVLRKDHQKKYGATV-DLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIIT 239 +K+Y V D+WS GVT Y G+ PF + P+ ++ + +I+ Sbjct: 181 L--------KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILG 227 >3TXO-A nrPDB Length = 353 Score = 216 bits (549), Expect = 4e-56, Method: Composition-based stats. Identities = 59/232 (25%), Positives = 103/232 (44%), Gaps = 21/232 (9%) Query: 7 HLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKL-N 63 + +LG+G+ V R K+TGDL+A+KV L+ DV+ M E +L N Sbjct: 23 DNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARN 82 Query: 64 HKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 123 H + +LF + T +MEF G L +++ E+ +++ + Sbjct: 83 HPFLTQLFCCFQ--TPDRLFFVMEFVNGGDLMFHIQKSRR---FDEARARFYAAEIISAL 137 Query: 124 NHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARE-LEDDEQFVSLYGTEEYLHP 182 L + GI++RD+K N++ D + KL DFG +E + + + GT +Y+ P Sbjct: 138 MFLHDKGIIYRDLKLDNVLL----DHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAP 193 Query: 183 DMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVM 234 ++ + + YG VD W++GV Y G PF + ++ Sbjct: 194 EILQEML--------YGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAIL 237 >4GS6-A nrPDB Length = 315 Score = 216 bits (549), Expect = 4e-56, Method: Composition-based stats. Identities = 63/270 (23%), Positives = 115/270 (42%), Gaps = 29/270 (10%) Query: 10 LLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVK 69 + +++G+GA V + + + AIK + S + V++R+ L ++NH NIVK Sbjct: 12 EVEEVVGRGAFGVVCKAKWRA--KDVAIKQIESESERKAFIVELRQ---LSRVNHPNIVK 66 Query: 70 LFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN 129 L+ L+ME+ GSLY VL + + G+ +L Sbjct: 67 LYGACLN----PVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSM 122 Query: 130 G---IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYE 186 ++HRD+KP N++ V G +V K+ DFG A +++ + G+ ++ P+++E Sbjct: 123 QPKALIHRDLKPPNLLLVA---GGTVLKICDFGTACDIQ--THMTNNKGSAAWMAPEVFE 177 Query: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAI 246 + Y D++S G+ + T PF GP +M+ + G I Sbjct: 178 GS--------NYSEKCDVFSWGIILWEVITRRKPFDEIGGPA--FRIMWAVHNGTRPPLI 227 Query: 247 SGVQKAENGPID--WSGDMPVSCSLSRGLQ 274 + K + WS D S+ ++ Sbjct: 228 KNLPKPIESLMTRCWSKDPSQRPSMEEIVK 257 >1FOT-A nrPDB Length = 318 Score = 215 bits (548), Expect = 5e-56, Method: Composition-based stats. Identities = 53/228 (23%), Positives = 101/228 (44%), Gaps = 21/228 (9%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNI--SFLRPVDVQMREFEVLKKLNHKN 66 + + LG G+ V R + G +A+KV L+ V+ E +L + H Sbjct: 8 FQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTHPF 67 Query: 67 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 126 I++++ ++ + +IM++ G L+++L + + P +V + +L Sbjct: 68 IIRMWGTFQDA--QQIFMIMDYIEGGELFSLLRK---SQRFPNPVAKFYAAEVCLALEYL 122 Query: 127 RENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYE 186 I++RD+KP NI+ D K+TDFG A+ + D +L GT +Y+ P++ Sbjct: 123 HSKDIIYRDLKPENILL----DKNGHIKITDFGFAKYVPD--VTYTLCGTPDYIAPEVVS 176 Query: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVM 234 K Y ++D WS G+ Y G PF + ++++ Sbjct: 177 --------TKPYNKSIDWWSFGILIYEMLAGYTPFYDSNTMKTYEKIL 216 >6ED6-A nrPDB Length = 415 Score = 215 bits (547), Expect = 6e-56, Method: Composition-based stats. Identities = 55/236 (23%), Positives = 106/236 (44%), Gaps = 18/236 (7%) Query: 3 STSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQM--REFEVLK 60 + + ++G+GA V RHK + ++A+K+ + ++ D E +++ Sbjct: 84 QMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMA 143 Query: 61 KLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVV 120 N +V+LF ++ R+ ++ME+ P G L ++ + Y +PE +VV Sbjct: 144 FANSPWVVQLFYAFQD--DRYLYMVMEYMPGGDLVNLM----SNYDVPEKWAKFYTAEVV 197 Query: 121 GGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDE--QFVSLYGTEE 178 ++ + G++HRD+KP N++ D KL DFG ++++ + GT + Sbjct: 198 LALDAIHSMGLIHRDVKPDNMLL----DKHGHLKLADFGTCMKMDETGMVHCDTAVGTPD 253 Query: 179 YLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVM 234 Y+ P++ + + YG D WS+GV Y G PF ++M Sbjct: 254 YISPEVLK----SQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIM 305 >2VZ6-A nrPDB Length = 313 Score = 215 bits (547), Expect = 7e-56, Method: Composition-based stats. Identities = 73/276 (26%), Positives = 117/276 (42%), Gaps = 38/276 (13%) Query: 7 HLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFL-RPVDVQMREFEVLKKLNHK 65 ++ L + LG+GA + V R G +A K+ N R RE + + L H Sbjct: 22 SMYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 81 Query: 66 NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 125 NIV+L E H LI + G L+ E+ E++ ++ ++ + H Sbjct: 82 NIVRLHDSISEEG--HHYLIFDLVTGGELF---EDIVAREYYSEADASHCIQQILEAVLH 136 Query: 126 LRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQ-FVSLYGTEEYLHPDM 184 + G+VHRD+KP N++ G + KL DFG A E+E ++Q + GT YL P++ Sbjct: 137 CHQMGVVHRDLKPENLLLASKLKGAA-VKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEV 195 Query: 185 YERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF----------------RPFEGPR 228 + YG VDLW+ GV Y G PF F P Sbjct: 196 LR--------KDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPE 247 Query: 229 RN------KEVMYKIITGKPSGAISGVQKAENGPID 258 + K+++ K++T PS I+ + ++ I Sbjct: 248 WDTVTPEAKDLINKMLTINPSKRITAAEALKHPWIS 283 >5U6Y-A nrPDB Length = 461 Score = 214 bits (546), Expect = 8e-56, Method: Composition-based stats. Identities = 73/275 (26%), Positives = 117/275 (42%), Gaps = 38/275 (13%) Query: 8 LWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFL-RPVDVQMREFEVLKKLNHKN 66 ++ L + LG+GA + V R G +A K+ N R RE + + L H N Sbjct: 1 MYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPN 60 Query: 67 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 126 IV+L E H LI + G L+ E+ E++ ++ ++ + H Sbjct: 61 IVRLHDSISEEG--HHYLIFDLVTGGELF---EDIVAREYYSEADASHCIQQILEAVLHC 115 Query: 127 RENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQ-FVSLYGTEEYLHPDMY 185 + G+VHRD+KP N++ G + KL DFG A E+E ++Q + GT YL P++ Sbjct: 116 HQMGVVHRDLKPENLLLASKLKGAA-VKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVL 174 Query: 186 ERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF----------------RPFEGPRR 229 + YG VDLW+ GV Y G PF F P Sbjct: 175 R--------KDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEW 226 Query: 230 N------KEVMYKIITGKPSGAISGVQKAENGPID 258 + K+++ K++T PS I+ + ++ I Sbjct: 227 DTVTPEAKDLINKMLTINPSKRITAAEALKHPWIS 261 >5D9K-A nrPDB Length = 330 Score = 214 bits (546), Expect = 9e-56, Method: Composition-based stats. Identities = 70/240 (29%), Positives = 114/240 (47%), Gaps = 26/240 (10%) Query: 7 HLWLLSDILGQGATANVFRGRHK---KTGDLFAIKVFNNISFL-RPVDVQMREFEVLKKL 62 + L +LGQG+ VF + L+A+KV + R E ++L ++ Sbjct: 30 SQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEV 89 Query: 63 NHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGG 122 NH IVKL + T LI++F G L+T L + E + L ++ Sbjct: 90 NHPFIVKLHYAFQ--TEGKLYLILDFLRGGDLFTRLSKE---VMFTEEDVKFYLAELALA 144 Query: 123 MNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARE-LEDDEQFVSLYGTEEYLH 181 ++HL GI++RD+KP NI+ D + KLTDFG ++E ++ +++ S GT EY+ Sbjct: 145 LDHLHSLGIIYRDLKPENILL----DEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMA 200 Query: 182 PDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 241 P++ R + + + D WS GV + TG+LPF+ + KE M I+ K Sbjct: 201 PEVVNR--------RGHTQSADWWSFGVLMFEMLTGTLPFQG----KDRKETMTMILKAK 248 >3GUB-A nrPDB Length = 295 Score = 214 bits (545), Expect = 1e-55, Method: Composition-based stats. Identities = 64/225 (28%), Positives = 102/225 (45%), Gaps = 18/225 (8%) Query: 2 QSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPV-----DVQMREF 56 Q + + + LG G A V + R K TG +A K + RE Sbjct: 6 QENVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREV 65 Query: 57 EVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVL 116 +LK++ H N++ L + E T +LI E G L+ L E + L E E L Sbjct: 66 SILKEIQHPNVITLHEVYENKTD--VILIGELVAGGELFDFLAEKES---LTEEEATEFL 120 Query: 117 RDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGT 176 + ++ G+ +L I H D+KP NIM + + K+ DFG A +++ +F +++GT Sbjct: 121 KQILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGT 180 Query: 177 EEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 E++ P++ L G D+WSIGV Y +G+ PF Sbjct: 181 PEFVAPEIVNYEPL--------GLEADMWSIGVITYILLSGASPF 217 >4UY9-A nrPDB Length = 323 Score = 214 bits (545), Expect = 1e-55, Method: Composition-based stats. Identities = 71/280 (25%), Positives = 115/280 (41%), Gaps = 30/280 (10%) Query: 10 LLSDILGQGATANVFRGRHKKTGDLFAIKVFN---NISFLRPVDVQMREFEVLKKLNHKN 66 L +I+G G V+R GD A+K + + ++ +E ++ L H N Sbjct: 12 TLEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPN 69 Query: 67 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 126 I+ L + + + L+MEF G L VL + +P + + GMN+L Sbjct: 70 IIALRGVCLKEP--NLCLVMEFARGGPLNRVL----SGKRIPPDILVNWAVQIARGMNYL 123 Query: 127 REN---GIVHRDIKPGNIMRVIGED----GQSVYKLTDFGAARELEDDEQFVSLYGTEEY 179 + I+HRD+K NI+ + + + K+TDFG ARE + S GT + Sbjct: 124 HDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKM-SAAGTYAW 182 Query: 180 LHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEV-MYKII 238 + P++ ++ + D+WS GV + TG +PFR +G V M K+ Sbjct: 183 MAPEVIRASM--------FSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLA 234 Query: 239 TGKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLT 278 PS K W+ D S + L L T Sbjct: 235 LPIPSTCPEPFAKLMEDC--WNPDPHSRPSFTNILDQLTT 272 >3DTC-A nrPDB Length = 271 Score = 214 bits (544), Expect = 2e-55, Method: Composition-based stats. Identities = 70/280 (25%), Positives = 114/280 (40%), Gaps = 30/280 (10%) Query: 10 LLSDILGQGATANVFRGRHKKTGDLFAIKVFN---NISFLRPVDVQMREFEVLKKLNHKN 66 L +I+G G V+R GD A+K + + ++ +E ++ L H N Sbjct: 10 TLEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPN 67 Query: 67 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 126 I+ L + + + L+MEF G L VL + +P + + GMN+L Sbjct: 68 IIALRGVCLKEP--NLCLVMEFARGGPLNRVL----SGKRIPPDILVNWAVQIARGMNYL 121 Query: 127 REN---GIVHRDIKPGNIMRVIGED----GQSVYKLTDFGAARELEDDEQFVSLYGTEEY 179 + I+HRD+K NI+ + + + K+TDFG ARE + S G + Sbjct: 122 HDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKM-SAAGAYAW 180 Query: 180 LHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEV-MYKII 238 + P++ ++ + D+WS GV + TG +PFR +G V M K+ Sbjct: 181 MAPEVIRASM--------FSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLA 232 Query: 239 TGKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLT 278 PS K W+ D S + L L T Sbjct: 233 LPIPSTCPEPFAKLMEDC--WNPDPHSRPSFTNILDQLTT 270 >2UV2-A nrPDB Length = 325 Score = 213 bits (543), Expect = 2e-55, Method: Composition-based stats. Identities = 70/259 (27%), Positives = 115/259 (44%), Gaps = 25/259 (9%) Query: 5 SNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNH 64 W + LG GA V++ ++K+T L A KV + S ++ M E ++L +H Sbjct: 35 PEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKS-EEELEDYMVEIDILASCDH 93 Query: 65 KNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 124 NIVKL + +++EFC G++ V+ E L ES+ +V + + +N Sbjct: 94 PNIVKLLDAFYYEN--NLWILIEFCAGGAVDAVMLELER--PLTESQIQVVCKQTLDALN 149 Query: 125 HLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFG-AARELEDDEQFVSLYGTEEYLHPD 183 +L +N I+HRD+K GNI+ + D KL DFG +A+ ++ S GT ++ P+ Sbjct: 150 YLHDNKIIHRDLKAGNILFTLDGD----IKLADFGVSAKNTRTIQRRDSFIGTPYWMAPE 205 Query: 184 MYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS 243 + + Y D+WS+G+T A P R V+ KI +P Sbjct: 206 VVM---CETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMR----VLLKIAKSEPP 258 Query: 244 GAISGVQKAENGPIDWSGD 262 P WS + Sbjct: 259 TLAQ--------PSRWSSN 269 >1PHK-A nrPDB Length = 298 Score = 213 bits (542), Expect = 2e-55, Method: Composition-based stats. Identities = 71/243 (29%), Positives = 117/243 (48%), Gaps = 24/243 (9%) Query: 7 HLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFN--------NISFLRPVDVQMREFEV 58 + +ILG+G ++ V R HK T +A+K+ + + ++E ++ Sbjct: 17 ENYEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQELREATLKEVDI 76 Query: 59 LKKLN-HKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLR 117 L+K++ H NI++L E T L+ + G L+ L E L E E ++R Sbjct: 77 LRKVSGHPNIIQLKDTYETNT--FFFLVFDLMKKGELFDYLTEK---VTLSEKETRKIMR 131 Query: 118 DVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTE 177 ++ + L + IVHRD+KP NI+ D KLTDFG + +L+ E+ + GT Sbjct: 132 ALLEVICALHKLNIVHRDLKPENILL----DDDMNIKLTDFGFSCQLDPGEKLREVCGTP 187 Query: 178 EYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKI 237 YL P++ E ++ D+ YG VD+WS GV Y GS PF R+ ++ I Sbjct: 188 SYLAPEIIECSM--NDNHPGYGKEVDMWSTGVIMYTLLAGSPPFW----HRKQMLMLRMI 241 Query: 238 ITG 240 ++G Sbjct: 242 MSG 244 >2A27-A nrPDB Length = 321 Score = 213 bits (542), Expect = 3e-55, Method: Composition-based stats. Identities = 67/225 (29%), Positives = 104/225 (46%), Gaps = 18/225 (8%) Query: 2 QSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPV-----DVQMREF 56 Q + + + LG G A V + R K TG +A K + RE Sbjct: 7 QQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREV 66 Query: 57 EVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVL 116 +L+++ H N++ L + E T VLI+E G L+ L + + L E E + Sbjct: 67 SILRQVLHHNVITLHDVYENRTD--VVLILELVSGGELFDFLAQKES---LSEEEATSFI 121 Query: 117 RDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGT 176 + ++ G+N+L I H D+KP NIM + KL DFG A E+ED +F +++GT Sbjct: 122 KQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGT 181 Query: 177 EEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 E++ P++ L G D+WSIGV Y +G+ PF Sbjct: 182 PEFVAPEIVNYEPL--------GLEADMWSIGVITYILLSGASPF 218 >4KRC-A nrPDB Length = 317 Score = 212 bits (541), Expect = 3e-55, Method: Composition-based stats. Identities = 70/289 (24%), Positives = 117/289 (40%), Gaps = 22/289 (7%) Query: 4 TSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLN 63 +S+ + + LG G A V++G +K TG A+K S +RE ++K+L Sbjct: 2 SSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELK 61 Query: 64 HKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPS---NAYGLPESEFLIVLRDVV 120 H+NIV+L+ + T L+ EF L ++ + GL + ++ Sbjct: 62 HENIVRLYDVIH--TENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLL 118 Query: 121 GGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELE-DDEQFVSLYGTEEY 179 G+ EN I+HRD+KP N++ + + KL DFG AR F S T Y Sbjct: 119 QGLAFCHENKILHRDLKPQNLLI----NKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWY 174 Query: 180 LHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIIT 239 PD+ + + Y ++D+WS G TG F + K + + T Sbjct: 175 RAPDVLMGS-------RTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGT 227 Query: 240 GKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQV-LLTPVLANILEA 287 S S + + P + L + LQ P+ N+++ Sbjct: 228 PNESLWPSVTKLPKYNP---NIQQRPPRDLRQVLQPHTKEPLDGNLMDF 273 >1ZWS-A nrPDB Length = 288 Score = 212 bits (541), Expect = 4e-55, Method: Composition-based stats. Identities = 67/225 (29%), Positives = 104/225 (46%), Gaps = 18/225 (8%) Query: 2 QSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPV-----DVQMREF 56 Q + + + LG G A V + R K TG +A K + RE Sbjct: 7 QQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREV 66 Query: 57 EVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVL 116 +L+++ H N++ L + E T VLI+E G L+ L + + L E E + Sbjct: 67 SILRQVLHHNVITLHDVYENRTD--VVLILELVSGGELFDFLAQKES---LSEEEATSFI 121 Query: 117 RDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGT 176 + ++ G+N+L I H D+KP NIM + KL DFG A E+ED +F +++GT Sbjct: 122 KQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGT 181 Query: 177 EEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 E++ P++ L G D+WSIGV Y +G+ PF Sbjct: 182 PEFVAPEIVNYEPL--------GLEADMWSIGVITYILLSGASPF 218 >6GU6-A nrPDB Length = 302 Score = 212 bits (539), Expect = 5e-55, Method: Composition-based stats. Identities = 71/292 (24%), Positives = 113/292 (38%), Gaps = 24/292 (8%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPV-DVQMREFEVLKKLNHKNI 67 + + +G+G V++GRHK TG + A+K S V +RE +LK+L H NI Sbjct: 9 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNI 68 Query: 68 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 127 V L + + + LI EF L L+ + S L ++ G+ Sbjct: 69 VSLQDVLMQDSR--LYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 125 Query: 128 ENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELE-DDEQFVSLYGTEEYLHPDMYE 186 ++HRD+KP N++ D + KL DFG AR + T Y P++ Sbjct: 126 SRRVLHRDLKPQNLLI----DDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLL 181 Query: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS--- 243 + +Y VD+WSIG F AT F + + + G P+ Sbjct: 182 GSA-------RYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRAL--GTPNNEV 232 Query: 244 -GAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWG 294 + +Q +N W S + L +L+ +L D K Sbjct: 233 WPEVESLQDYKNTFPKWKPG--SLASHVKNLDENGLDLLSKMLIYDPAKRIS 282 >3GC9-A nrPDB Length = 370 Score = 212 bits (539), Expect = 6e-55, Method: Composition-based stats. Identities = 68/306 (22%), Positives = 119/306 (38%), Gaps = 35/306 (11%) Query: 2 QSTSNHLWLLSDIL------GQGATANVFRGRHKKTGDLFAIKVF-NNISFLRPVDVQMR 54 Q + +W + L G GA +V + A+K L R Sbjct: 17 QELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYR 76 Query: 55 EFEVLKKLNHKNIVKLFAIEEETTT----RHKVLIMEFCPCGSLYTVLEEPSNAYGLPES 110 E +LK L H+N++ L + T+ L+ L +++ + L + Sbjct: 77 ELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVK----SQALSDE 131 Query: 111 EFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQF 170 ++ ++ G+ ++ GI+HRD+KP N+ + ED + ++ DFG AR+ DE+ Sbjct: 132 HVQFLVYQLLRGLKYIHSAGIIHRDLKPSNV--AVNEDSE--LRILDFGLARQ--ADEEM 185 Query: 171 VSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRN 230 T Y P++ + Y TVD+WS+G G F + + Sbjct: 186 TGYVATRWYRAPEIM-------LNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQL 238 Query: 231 KEVMYKIITGKPSGAISGVQKAENGP--IDWSGDMPVS--CSLSRGLQVLLTPVLANILE 286 K +M + G PS + +E+ I MP S+ RG L +L +L Sbjct: 239 KRIME--VVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLV 296 Query: 287 ADQEKC 292 D ++ Sbjct: 297 LDSDQR 302 >3ZUT-A nrPDB Length = 362 Score = 212 bits (539), Expect = 6e-55, Method: Composition-based stats. Identities = 71/351 (20%), Positives = 130/351 (37%), Gaps = 47/351 (13%) Query: 6 NHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHK 65 + + L +G G R K++ +L A+K + + RE + L H Sbjct: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKID--ENVKREIINHRSLRHP 75 Query: 66 NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 125 NIV+ + T H ++ME+ G L+ + NA E E + ++ G+++ Sbjct: 76 NIVRFKEVILTPT--HLAIVMEYASGGELFERI---CNAGRFSEDEARFFFQQLISGVSY 130 Query: 126 LRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMY 185 + HRD+K N + K+ FG ++ Q S GT Y+ P++ Sbjct: 131 CHAMQVCHRDLKLENTLL--DGSPAPRLKICAFGYSKSSVLHSQPKSTVGTPAYIAPEVL 188 Query: 186 ERAVLRKDHQKKYGATV-DLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSG 244 +K+Y V D+WS GVT Y G+ PF E P+ ++ +++I+ Sbjct: 189 L--------KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILN----- 235 Query: 245 AISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFAETSD 304 + ++ P +S + L ++ I AD K + Sbjct: 236 ------------VQYAI--PDYVHISPECRHL----ISRIFVADPAKRISIPE-IRNHEW 276 Query: 305 ILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVY---KQTKIISSNQEL 352 L + + + MT + S E++ + T + Q L Sbjct: 277 FLKNLPADLMNDNTMTTQ--FDESDQPGQSIEEIMQIIAEATVPPAGTQNL 325 >4QMW-A nrPDB Length = 310 Score = 211 bits (538), Expect = 6e-55, Method: Composition-based stats. Identities = 66/307 (21%), Positives = 129/307 (42%), Gaps = 34/307 (11%) Query: 1 MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLK 60 +++ L+ + +G+G+ VF+G +T + AIK+ + ++ +E VL Sbjct: 23 LKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLS 82 Query: 61 KLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVV 120 + + + K + + T +IME+ GS +LE L E++ +LR+++ Sbjct: 83 QCDSPYVTKYYGSYLKDTK--LWIIMEYLGGGSALDLLE----PGPLDETQIATILREIL 136 Query: 121 GGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDE-QFVSLYGTEEY 179 G+++L +HRDIK N++ KL DFG A +L D + + + GT + Sbjct: 137 KGLDYLHSEKKIHRDIKAANVLLS----EHGEVKLADFGVAGQLTDTQIKRNTFVGTPFW 192 Query: 180 LHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIIT 239 + P++ +++ Y + D+WS+G+T A G P + V++ I Sbjct: 193 MAPEVIKQSA--------YDSKADIWSLGITAIELARGEPPHSELHPMK----VLFLIPK 240 Query: 240 GKPSGAISGVQKAENGPIDWSGDM-PVSCSLSRGL--------QVLLTPVLANILEADQE 290 P K ++ + P ++ L T L ++ D+ Sbjct: 241 NNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELI--DRY 298 Query: 291 KCWGFDQ 297 K W +Q Sbjct: 299 KRWKAEQ 305 >2V7O-A nrPDB Length = 336 Score = 211 bits (538), Expect = 8e-55, Method: Composition-based stats. Identities = 61/227 (26%), Positives = 102/227 (44%), Gaps = 16/227 (7%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFL-RPVDVQMREFEVLKKLNHKNI 67 + L + LG+GA + V R K +A K+ N R RE + + L H NI Sbjct: 33 YQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 92 Query: 68 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 127 V+L E L+ + G L+ E+ E++ + ++ +NH+ Sbjct: 93 VRLHDSISEEG--FHYLVFDLVTGGELF---EDIVAREYYSEADASHCIHQILESVNHIH 147 Query: 128 ENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQ-FVSLYGTEEYLHPDMYE 186 ++ IVHRD+KP N++ G + KL DFG A E++ ++Q + GT YL P++ Sbjct: 148 QHDIVHRDLKPENLLLASKCKGAA-VKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLR 206 Query: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEV 233 + YG VD+W+ GV Y G PF + + +++ Sbjct: 207 --------KDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQI 245 >4WB7-A nrPDB Length = 405 Score = 211 bits (537), Expect = 1e-54, Method: Composition-based stats. Identities = 63/251 (25%), Positives = 113/251 (45%), Gaps = 28/251 (11%) Query: 13 DILGQGATANVFRGRHKKTGDLFAIKVFNNISF--LRPVDVQMREFEVLKKLNHKNIVKL 70 LG G+ V +HK+TG+ +A+K+ + L+ ++ + E +L+ +N +VKL Sbjct: 102 KTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKL 161 Query: 71 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 130 + ++ME+ P G +++ L E +V +L Sbjct: 162 E--FSFKDNSNLYMVMEYVPGGEMFSHLRRIGR---FSEPHARFYAAQIVLTFEYLHSLD 216 Query: 131 IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVL 190 +++RD+KP N++ D Q ++TDFG A+ ++ + +L GT EYL P++ Sbjct: 217 LIYRDLKPENLLI----DQQGYIQVTDFGFAKRVK--GRTWTLCGTPEYLAPEIIL---- 266 Query: 191 RKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK---PSGAIS 247 K Y VD W++GV Y A G PF + ++ KI++GK PS S Sbjct: 267 ----SKGYNKAVDWWALGVLIYEMAAGYPPFFADQPI----QIYEKIVSGKVRFPSHFSS 318 Query: 248 GVQKAENGPID 258 ++ + Sbjct: 319 DLKDLLRNLLQ 329 >5X3F-B nrPDB Length = 393 Score = 211 bits (537), Expect = 1e-54, Method: Composition-based stats. Identities = 61/251 (24%), Positives = 112/251 (44%), Gaps = 28/251 (11%) Query: 13 DILGQGATANVFRGRHKKTGDLFAIKVFNNISF--LRPVDVQMREFEVLKKLNHKNIVKL 70 LG G+ V +HK++G+ +A+K+ + L+ ++ + E +L+ +N +VKL Sbjct: 90 KTLGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKL 149 Query: 71 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 130 + ++ME+ G +++ L E +V +L Sbjct: 150 E--FSFKDNSNLYMVMEYVAGGEMFSHLRRIGR---FSEPHARFYAAQIVLTFEYLHSLD 204 Query: 131 IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVL 190 +++RD+KP N++ D Q ++TDFG A+ ++ + +L GT EYL P++ Sbjct: 205 LIYRDLKPENLLI----DQQGYIQVTDFGFAKRVK--GRTWTLCGTPEYLAPEIIL---- 254 Query: 191 RKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK---PSGAIS 247 K Y VD W++GV Y A G PF + ++ KI++GK PS S Sbjct: 255 ----SKGYNKAVDWWALGVLIYEMAAGYPPFFADQPI----QIYEKIVSGKVRFPSHFSS 306 Query: 248 GVQKAENGPID 258 ++ + Sbjct: 307 DLKDLLRNLLQ 317 >4RA4-A nrPDB Length = 355 Score = 211 bits (536), Expect = 1e-54, Method: Composition-based stats. Identities = 56/230 (24%), Positives = 102/230 (44%), Gaps = 21/230 (9%) Query: 14 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHK-NIVKL 70 +LG+G+ V K T +L+AIK+ ++ DV+ M E VL L+ + +L Sbjct: 27 VLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQL 86 Query: 71 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 130 + + T +ME+ G L +++ E + + ++ G+ L + G Sbjct: 87 HSCFQ--TVDRLYFVMEYVNGGDLMYHIQQVGK---FKEPQAVFYAAEISIGLFFLHKRG 141 Query: 131 IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARE-LEDDEQFVSLYGTEEYLHPDMYERAV 189 I++RD+K N+M D + K+ DFG +E + D + GT +Y+ P++ Sbjct: 142 IIYRDLKLDNVML----DSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIA--- 194 Query: 190 LRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIIT 239 + YG +VD W+ GV Y G PF + + +M ++ Sbjct: 195 -----YQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVS 239 >5N23-A nrPDB Length = 352 Score = 211 bits (536), Expect = 1e-54, Method: Composition-based stats. Identities = 61/251 (24%), Positives = 110/251 (43%), Gaps = 27/251 (10%) Query: 13 DILGQGATANVFRGRHKKTGDLFAIKVFNNISF--LRPVDVQMREFEVLKKLNHKNIVKL 70 LG G+ V +HK+TG+ +A+K+ + L+ ++ + E + + +N +VKL Sbjct: 48 RTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRIQQAVNFPFLVKL 107 Query: 71 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 130 + +++E+ P G +++ L E +V +L Sbjct: 108 E--FSFKDNSNLYMVLEYAPGGEMFSHLRRIGR---FSEPHARFYAAQIVLTFEYLHSLD 162 Query: 131 IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVL 190 +++RD+KP N++ D Q K+ DFG A+ ++ +L GT EYL P++ Sbjct: 163 LIYRDLKPENLLI----DQQGYIKVADFGFAKRVK-GRTPWTLCGTPEYLAPEIIL---- 213 Query: 191 RKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK---PSGAIS 247 K Y VD W++GV Y A G PF + ++ KI++GK PS S Sbjct: 214 ----SKGYNKAVDWWALGVLIYEMAAGYPPFFADQPI----QIYEKIVSGKVRFPSHFSS 265 Query: 248 GVQKAENGPID 258 ++ + Sbjct: 266 DLKDLLRNLLQ 276 >2JDO-A nrPDB Length = 342 Score = 210 bits (535), Expect = 2e-54, Method: Composition-based stats. Identities = 60/225 (26%), Positives = 92/225 (40%), Gaps = 20/225 (8%) Query: 13 DILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHKNIVKL 70 +LG+G V R K TG +A+K+ + +V + E VL+ H + L Sbjct: 16 KLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTAL 75 Query: 71 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 130 + T +ME+ G L+ L E ++V + +L Sbjct: 76 KYAFQ--THDRLCFVMEYANGGELFFHLSRER---VFTEERARFYGAEIVSALEYLHSRD 130 Query: 131 IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARE-LEDDEQFVSLYGTEEYLHPDMYERAV 189 +V+RDIK N+M D K+TDFG +E + D + GT EYL P++ E Sbjct: 131 VVYRDIKLENLML----DKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLE--- 183 Query: 190 LRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVM 234 YG VD W +GV Y G LPF + R + ++ Sbjct: 184 -----DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELIL 223 >4NIF-A nrPDB Length = 333 Score = 210 bits (534), Expect = 2e-54, Method: Composition-based stats. Identities = 58/235 (24%), Positives = 110/235 (46%), Gaps = 21/235 (8%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIV 68 +++ + +G G+ + R HK T +A+KV + ++++ +L+ H NI+ Sbjct: 10 YVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIEI----LLRYGQHPNII 65 Query: 69 KLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE 128 L + ++ +H L+ E G L L++ E E VL + + +L Sbjct: 66 TLKDVYDDG--KHVYLVTELMRGGEL---LDKILRQKFFSEREASFVLHTIGKTVEYLHS 120 Query: 129 NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELE-DDEQFVSLYGTEEYLHPDMYER 187 G+VHRD+KP NI+ V ++ DFG A++L ++ ++ T ++ P++ +R Sbjct: 121 QGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKR 180 Query: 188 AVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRN-KEVMYKIITGK 241 + Y D+WS+G+ Y G PF GP +E++ +I +GK Sbjct: 181 --------QGYDEGCDIWSLGILLYTMLAGYTPFA--NGPSDTPEEILTRIGSGK 225 >3UDB-A nrPDB Length = 317 Score = 210 bits (534), Expect = 2e-54, Method: Composition-based stats. Identities = 57/234 (24%), Positives = 99/234 (42%), Gaps = 18/234 (7%) Query: 6 NHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHK 65 + + L +G G R K+ +L A+K + + RE + L H Sbjct: 18 SDRYELVKDIGAGNFGVARLMRDKQANELVAVKYIERGEKID--ENVKREIINHRSLRHP 75 Query: 66 NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 125 NIV+ + T H ++ME+ G L+ + NA E E + ++ G+++ Sbjct: 76 NIVRFKEVILTPT--HLAIVMEYASGGELFERI---CNAGRFSEDEARFFFQQLISGVSY 130 Query: 126 LRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMY 185 + HRD+K N + K+ DFG ++ Q S GT Y+ P++ Sbjct: 131 AHAMQVAHRDLKLENTLL--DGSPAPRLKIADFGYSKASVLHSQPKSAVGTPAYIAPEVL 188 Query: 186 ERAVLRKDHQKKYGATV-DLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKII 238 +K+Y V D+WS GVT Y G+ PF E P+ ++ +++I+ Sbjct: 189 L--------KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRIL 234 >3PPZ-A nrPDB Length = 309 Score = 210 bits (534), Expect = 2e-54, Method: Composition-based stats. Identities = 65/277 (23%), Positives = 106/277 (38%), Gaps = 22/277 (7%) Query: 11 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFL-RPVDVQMREFEVLKKLNHKNIVK 69 + + +G G+ V R G A+K+ F V+ +RE ++K+L H NIV Sbjct: 41 IKEKIGAGSFGTVHRAEWH--GSDVAVKILMEQDFHAERVNEFLREVAIMKRLRHPNIVL 98 Query: 70 LFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN 129 + + ++ E+ GSLY +L + L E L + DV GMN+L Sbjct: 99 FMGAVTQPP--NLSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGMNYLHNR 156 Query: 130 G--IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDE-QFVSLYGTEEYLHPDMYE 186 IVHRD+K N++ D + K+ DFG +R S GT E++ P++ Sbjct: 157 NPPIVHRDLKSPNLLV----DKKYTVKVCDFGLSRLKASTFLSSKSAAGTPEWMAPEVLR 212 Query: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYK-IITGKPSGA 245 D++S GV + AT P+ + V +K P Sbjct: 213 DEPSN--------EKSDVYSFGVILWELATLQQPWGNLNPAQVVAAVGFKCKRLEIPRNL 264 Query: 246 ISGVQKAENGPIDWSG-DMPVSCSLSRGLQVLLTPVL 281 V G P ++ L+ L+ + Sbjct: 265 NPQVAAIIEGCWTNEPWKRPSFATIMDLLRPLIKSAV 301 >4JG6-A nrPDB Length = 355 Score = 210 bits (534), Expect = 2e-54, Method: Composition-based stats. Identities = 64/240 (26%), Positives = 113/240 (47%), Gaps = 23/240 (9%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKL-NHKNI 67 + + + +G G+ + R HK T FA+K+ + P + E E+L + H NI Sbjct: 37 YEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSK-RDPTE----EIEILLRYGQHPNI 91 Query: 68 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 127 + L + ++ ++ ++ E G L L++ E E VL + + +L Sbjct: 92 ITLKDVYDDG--KYVYVVTELMKGGEL---LDKILRQKFFSEREASAVLFTITKTVEYLH 146 Query: 128 ENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELE-DDEQFVSLYGTEEYLHPDMYE 186 G+VHRD+KP NI+ V ++ DFG A++L ++ ++ T ++ P++ E Sbjct: 147 AQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLE 206 Query: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRN-KEVMYKIITGKPSGA 245 R + Y A D+WS+GV Y TG PF GP +E++ +I +GK S + Sbjct: 207 R--------QGYDAACDIWSLGVLLYTMLTGYTPFA--NGPDDTPEEILARIGSGKFSLS 256 >3BHH-A nrPDB Length = 295 Score = 209 bits (533), Expect = 3e-54, Method: Composition-based stats. Identities = 61/227 (26%), Positives = 102/227 (44%), Gaps = 16/227 (7%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFL-RPVDVQMREFEVLKKLNHKNI 67 + L + +G+GA + V R TG +A K+ N R RE + + L H NI Sbjct: 6 YQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNI 65 Query: 68 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 127 V+L E L+ + G L+ E+ E++ ++ ++ + H Sbjct: 66 VRLHDSISEEG--FHYLVFDLVTGGELF---EDIVAREYYSEADASHCIQQILEAVLHCH 120 Query: 128 ENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQ-FVSLYGTEEYLHPDMYE 186 + G+VHRD+KP N++ G + KL DFG A E++ D+Q + GT YL P++ Sbjct: 121 QMGVVHRDLKPENLLLASKCKGAA-VKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLR 179 Query: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEV 233 + YG VD+W+ GV Y G PF + + +++ Sbjct: 180 KEA--------YGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQI 218 >4YNZ-A nrPDB Length = 342 Score = 209 bits (533), Expect = 3e-54, Method: Composition-based stats. Identities = 62/260 (23%), Positives = 105/260 (40%), Gaps = 24/260 (9%) Query: 8 LWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQM-REFEVLKKLNHKN 66 + L LG+G T V G H T AIK+ N V +++ RE +LK + H + Sbjct: 11 PYRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPH 70 Query: 67 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 126 ++KL + E ++ L++E G L+ L + L E R ++ ++ Sbjct: 71 VLKLHDVYEN--KKYLYLVLEHVSGGELFDYLVKKGR---LTPKEARKFFRQIISALDFC 125 Query: 127 RENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYE 186 + I HRD+KP N++ D ++ ++ DFG A D + G+ Y P++ Sbjct: 126 HSHSICHRDLKPENLLL----DERNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIR 181 Query: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITG---KPS 243 G D+WS GV + G+LPF ++++ K+ G P Sbjct: 182 GEKYD-------GRKADVWSCGVILFALLVGALPF----DDDNLRQLLEKVKRGVFHMPH 230 Query: 244 GAISGVQKAENGPIDWSGDM 263 Q G I+ Sbjct: 231 FIPPDCQSLLRGMIEVDAAR 250 >4D2V-A nrPDB Length = 356 Score = 209 bits (531), Expect = 5e-54, Method: Composition-based stats. Identities = 63/237 (26%), Positives = 104/237 (43%), Gaps = 22/237 (9%) Query: 7 HLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKN 66 + L + +G G A V H TG++ AIK+ + + + E E LK L H++ Sbjct: 29 KYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNLRHQH 88 Query: 67 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 126 I +L+ + E T +++E+CP G L+ + + L E E +V R +V + ++ Sbjct: 89 ICQLYHVLE--TANKIFMVLEYCPGGELFDYI---ISQDRLSEEETRVVFRQIVSAVAYV 143 Query: 127 RENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAAR--ELEDDEQFVSLYGTEEYLHPDM 184 G HRD+KP N++ D KL DFG + D + G Y P++ Sbjct: 144 HSQGYAHRDLKPENLLF----DEYHKLKLIDFGLCAKPKGNKDYHLQACCGALAYAAPEL 199 Query: 185 YERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 241 + G+ D+WS+G+ Y G LPF ++ KI+ GK Sbjct: 200 IQGKSYL-------GSEADVWSMGILLYVLMCGFLPF----DDDTAAALVAKIMRGK 245 >2Y7J-A nrPDB Length = 365 Score = 208 bits (530), Expect = 6e-54, Method: Composition-based stats. Identities = 68/243 (27%), Positives = 113/243 (46%), Gaps = 23/243 (9%) Query: 7 HLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFN-------NISFLRPVDVQMREFEVL 59 + D++G+G ++ V R H+ TG FA+K+ + RE +L Sbjct: 94 QKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHIL 153 Query: 60 KKL-NHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRD 118 +++ H +I+ L E ++ L+ + G L+ L E L E E ++R Sbjct: 154 RQVAGHPHIITLIDSYESSS--FMFLVFDLMRKGELFDYLTEK---VALSEKETRSIMRS 208 Query: 119 VVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEE 178 ++ ++ L N IVHRD+KP NI+ D +L+DFG + LE E+ L GT Sbjct: 209 LLEAVSFLHANNIVHRDLKPENILL----DDNMQIRLSDFGFSCHLEPGEKLRELCGTPG 264 Query: 179 YLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKII 238 YL P++ + ++ + YG VDLW+ GV + GS PF RR ++ I+ Sbjct: 265 YLAPEILKCSM--DETHPGYGKEVDLWACGVILFTLLAGSPPFW----HRRQILMLRMIM 318 Query: 239 TGK 241 G+ Sbjct: 319 EGQ 321 >2X4F-A nrPDB Length = 373 Score = 208 bits (530), Expect = 6e-54, Method: Composition-based stats. Identities = 59/235 (25%), Positives = 104/235 (44%), Gaps = 17/235 (7%) Query: 2 QSTSNHLWLLS--DILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVL 59 Q N + +S +ILG G V + TG A K+ ++ + E V+ Sbjct: 82 QGAVNSFYTVSKTEILGGGRFGQVHKCEETATGLKLAAKIIK-TRGMKDKEEVKNEISVM 140 Query: 60 KKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDV 119 +L+H N+++L+ E VL+ME+ G L+ + +Y L E + ++ ++ + Sbjct: 141 NQLDHANLIQLYDAFESKND--IVLVMEYVDGGELFDRI--IDESYNLTELDTILFMKQI 196 Query: 120 VGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEY 179 G+ H+ + I+H D+KP NI+ V K+ DFG AR + E+ +GT E+ Sbjct: 197 CEGIRHMHQMYILHLDLKPENILCV--NRDAKQIKIIDFGLARRYKPREKLKVNFGTPEF 254 Query: 180 LHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVM 234 L P++ + D+WS+GV Y +G PF ++ Sbjct: 255 LAPEVVNYDFV--------SFPTDMWSVGVIAYMLLSGLSPFLGDNDAETLNNIL 301 >3COM-A nrPDB Length = 314 Score = 208 bits (530), Expect = 7e-54, Method: Composition-based stats. Identities = 60/241 (24%), Positives = 114/241 (47%), Gaps = 24/241 (9%) Query: 5 SNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNH 64 ++ + + LG+G+ +V++ HK+TG + AIK S L+ + ++E ++++ + Sbjct: 27 PEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEI---IKEISIMQQCDS 83 Query: 65 KNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 124 ++VK + + T ++ME+C GS+ ++ L E E +L+ + G+ Sbjct: 84 PHVVKYYGSYFKNTD--LWIVMEYCGAGSVSDIIR--LRNKTLTEDEIATILQSTLKGLE 139 Query: 125 HLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD-EQFVSLYGTEEYLHPD 183 +L +HRDIK GNI+ + + KL DFG A +L D + ++ GT ++ P+ Sbjct: 140 YLHFMRKIHRDIKAGNILL----NTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPE 195 Query: 184 MYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS 243 + + Y D+WS+G+T A G P+ R ++ I T P Sbjct: 196 VIQEI--------GYNCVADIWSLGITAIEMAEGKPPYADIHPMRA----IFMIPTNPPP 243 Query: 244 G 244 Sbjct: 244 T 244 >4JXF-A nrPDB Length = 266 Score = 208 bits (529), Expect = 7e-54, Method: Composition-based stats. Identities = 57/216 (26%), Positives = 106/216 (49%), Gaps = 19/216 (8%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRP--VDVQMREFEVLKKLNHKN 66 + + ++LG+G+ A V+R TG AIK+ + + + V E ++ +L H + Sbjct: 9 FKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPS 68 Query: 67 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 126 I++L+ E++ + L++E C G + L+ + E+E + ++ GM +L Sbjct: 69 ILELYNYFEDSN--YVYLVLEMCHNGEMNRYLK--NRVKPFSENEARHFMHQIITGMLYL 124 Query: 127 RENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELE-DDEQFVSLYGTEEYLHPDMY 185 +GI+HRD+ N++ + K+ DFG A +L+ E+ +L GT Y+ P++ Sbjct: 125 HSHGILHRDLTLSNLLLTRNMN----IKIADFGLATQLKMPHEKHYTLCGTPNYISPEIA 180 Query: 186 ERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 R+ +G D+WS+G FY G PF Sbjct: 181 TRSA--------HGLESDVWSLGCMFYTLLIGRPPF 208 >4EWQ-A nrPDB Length = 383 Score = 208 bits (529), Expect = 7e-54, Method: Composition-based stats. Identities = 62/293 (21%), Positives = 109/293 (37%), Gaps = 25/293 (8%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVF-NNISFLRPVDVQMREFEVLKKLNHKNIVKLFAI 73 +G GA +V KTG A+K + RE +LK + H+N++ L + Sbjct: 53 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDV 112 Query: 74 EEETTTRH----KVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN 129 + L+ L +++ L + ++ ++ G+ ++ Sbjct: 113 FTPARSLEEFNDVYLVTHLM-GADLNNIVK----CQKLTDDHVQFLIYQILRGLKYIHSA 167 Query: 130 GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAV 189 I+HRD+KP N + ED + K+ DFG AR D++ T Y P++ Sbjct: 168 DIIHRDLKPSN--LAVNEDCE--LKILDFGLAR--HTDDEMTGYVATRWYRAPEIM---- 217 Query: 190 LRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGV 249 + Y TVD+WS+G TG F + + K ++ + T Sbjct: 218 ---LNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKIS 274 Query: 250 QKAENGPIDWSGDMPV--SCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFA 300 ++ I MP ++ G L +L +L D +K Q A Sbjct: 275 SESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALA 327 >3DAK-A nrPDB Length = 290 Score = 208 bits (529), Expect = 8e-54, Method: Composition-based stats. Identities = 72/296 (24%), Positives = 123/296 (41%), Gaps = 29/296 (9%) Query: 3 STSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKL 62 S + + L +++G GATA V + AIK N +D ++E + + + Sbjct: 6 SINRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQC 65 Query: 63 NHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEE-----PSNAYGLPESEFLIVLR 117 +H NIV + L+M+ GS+ +++ + L ES +LR Sbjct: 66 HHPNIVSYYTSF--VVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILR 123 Query: 118 DVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFV------ 171 +V+ G+ +L +NG +HRD+K GNI+ GEDG ++ DFG + L Sbjct: 124 EVLEGLEYLHKNGQIHRDVKAGNILL--GEDGS--VQIADFGVSAFLATGGDITRNKVRK 179 Query: 172 SLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNK 231 + GT ++ P++ E+ + Y D+WS G+T ATG+ P+ + + Sbjct: 180 TFVGTPCWMAPEVMEQV-------RGYDFKADIWSFGITAIELATGAAPYHKYPPMK--- 229 Query: 232 EVMYKIITGKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEA 287 V+ + P +GVQ E + SL P A +L Sbjct: 230 -VLMLTLQNDPPSLETGVQDKEMLK-KYGKSFRKMISLCLQKDPEKRPTAAELLRH 283 >4IC8-A nrPDB Length = 442 Score = 208 bits (529), Expect = 9e-54, Method: Composition-based stats. Identities = 60/306 (19%), Positives = 109/306 (35%), Gaps = 31/306 (10%) Query: 3 STSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVF-NNISFLRPVDVQMREFEVLKK 61 + + + +G GA V R + TG AIK N + +RE ++LK Sbjct: 51 FDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKH 110 Query: 62 LNHKNIVKLFAIEEETTT----RHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLR 117 H NI+ + I T + ++++ L+ ++ ++ L L Sbjct: 111 FKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMES-DLHQIIH---SSQPLTLEHVRYFLY 166 Query: 118 DVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAAREL-----EDDEQFVS 172 ++ G+ ++ ++HRD+KP N++ + K+ DFG AR L E Sbjct: 167 QLLRGLKYMHSAQVIHRDLKPSNLLV----NENCELKIGDFGMARGLCTSPAEHQYFMTE 222 Query: 173 LYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKE 232 T Y P++ +Y +DLWS+G F F + + Sbjct: 223 YVATRWYRAPELMLSL-------HEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQL 275 Query: 233 VMYKIITGKPSGAISGVQKAENGP--IDWSGDMPVSC--SLSRGLQVLLTPVLANILEAD 288 +M ++ G PS A+ AE I ++ G +L +L + Sbjct: 276 IM--MVLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFE 333 Query: 289 QEKCWG 294 Sbjct: 334 PSARIS 339 >5Z33-A nrPDB Length = 425 Score = 208 bits (529), Expect = 9e-54, Method: Composition-based stats. Identities = 59/309 (19%), Positives = 116/309 (37%), Gaps = 32/309 (10%) Query: 3 STSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLR-PVDVQMREFEVLKK 61 + + ++ LGQGA V + +T + AIK N+ + +RE ++L+ Sbjct: 27 FIVDERYTVTKELGQGAYGIVCAAVNNQTSEGVAIKKVTNVFSKKILAKRALREIKLLQH 86 Query: 62 LN-HKNIVKLFA--IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRD 118 H+NI L+ I L E C L ++ + L ++ F + Sbjct: 87 FRGHRNITCLYDMDIPRPDNFNETYLYEELMEC-DLAAIIR---SGQPLTDAHFQSFIYQ 142 Query: 119 VVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQ-----FVSL 173 ++ G+ ++ ++HRD+KPGN++ + K+ DFG AR D + Sbjct: 143 ILCGLKYIHSANVLHRDLKPGNLLV----NADCELKICDFGLARGFSVDPEENAGYMTEY 198 Query: 174 YGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEV 233 T Y P++ + Y +D+WS+G G F+ + + ++ Sbjct: 199 VATRWYRAPEIM-------LSFQSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQI 251 Query: 234 MYKIITGKPSGAISGVQKAENGPIDWSGDMP-----VSCSLSRGLQVLLTPVLANILEAD 288 ++ I G P+ + ++ ++P +L +L +L D Sbjct: 252 LH--ILGTPNEETLSRIGSPRAQ-EYVRNLPFMAKKPFPTLFPNANPDALDLLDRMLAFD 308 Query: 289 QEKCWGFDQ 297 +Q Sbjct: 309 PSSRISVEQ 317 >4RLP-A nrPDB Length = 288 Score = 207 bits (528), Expect = 1e-53, Method: Composition-based stats. Identities = 68/253 (26%), Positives = 107/253 (42%), Gaps = 25/253 (9%) Query: 9 WLLSDILGQGATANVFRGRHK---KTGDLFAIKVFNN---ISFLRPVDVQMREFEVLKKL 62 + L +LG+G VF+ R TG +FA+KV + + E +L+++ Sbjct: 7 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEV 66 Query: 63 NHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGG 122 H IV L + T LI+E+ G L+ LE E L ++ Sbjct: 67 KHPFIVDLIYAFQ--TGGKLYLILEYLSGGELFMQLEREG---IFMEDTACFYLAEISMA 121 Query: 123 MNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARE-LEDDEQFVSLYGTEEYLH 181 + HL + GI++RD+KP NIM + Q KLTDFG +E + D + GT EY+ Sbjct: 122 LGHLHQKGIIYRDLKPENIML----NHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMA 177 Query: 182 PDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 241 P++ R+ + VD WS+G Y TG+ PF E ++ + + K Sbjct: 178 PEILMRS--------GHNRAVDWWSLGALMYDMLTGAPPFTG-ENRKKTIDKILKCKLNL 228 Query: 242 PSGAISGVQKAEN 254 P + Sbjct: 229 PPYLTQEARDLLK 241 >3KN6-A nrPDB Length = 325 Score = 207 bits (528), Expect = 1e-53, Method: Composition-based stats. Identities = 66/234 (28%), Positives = 109/234 (46%), Gaps = 23/234 (9%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLN-HKNIVKLFAI 73 LG+G+ + + HKK+ FA+K+ + +E LK H NIVKL + Sbjct: 19 LGEGSFSICRKCVHKKSNQAFAVKIISKRMEAN----TQKEITALKLCEGHPNIVKLHEV 74 Query: 74 EEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVH 133 + H L+ME G L+ +++ + E+E ++R +V ++H+ + G+VH Sbjct: 75 FHDQ--LHTFLVMELLNGGELFERIKKKKH---FSETEASYIMRKLVSAVSHMHDVGVVH 129 Query: 134 RDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD-EQFVSLYGTEEYLHPDMYERAVLRK 192 RD+KP N++ E+ K+ DFG AR D + + T Y P++ Sbjct: 130 RDLKPENLLFT-DENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELL------- 181 Query: 193 DHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNK---EVMYKIITGKPS 243 +Q Y + DLWS+GV Y +G +PF+ + E+M KI G S Sbjct: 182 -NQNGYDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFS 234 >2XIK-A nrPDB Length = 294 Score = 207 bits (527), Expect = 1e-53, Method: Composition-based stats. Identities = 60/256 (23%), Positives = 111/256 (43%), Gaps = 23/256 (8%) Query: 4 TSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLN 63 L+ D +G+G+ V++G T ++ AIK+ + ++ +E VL + + Sbjct: 16 DPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 75 Query: 64 HKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 123 I + F ++T +IME+ GS +L+ L E+ +LR+++ G+ Sbjct: 76 SPYITRYFGSYLKSTK--LWIIMEYLGGGSALDLLK----PGPLEETYIATILREILKGL 129 Query: 124 NHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDE-QFVSLYGTEEYLHP 182 ++L +HRDIK N++ D KL DFG A +L D + + + GT ++ P Sbjct: 130 DYLHSERKIHRDIKAANVLLSEQGD----VKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 185 Query: 183 DMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKP 242 ++ +++ Y D+WS+G+T A G P R V++ I P Sbjct: 186 EVIKQSA--------YDFKADIWSLGITAIELAKGEPPNSDLHPMR----VLFLIPKNSP 233 Query: 243 SGAISGVQKAENGPID 258 K ++ Sbjct: 234 PTLEGQHSKPFKEFVE 249 >4L42-A nrPDB Length = 346 Score = 207 bits (527), Expect = 1e-53, Method: Composition-based stats. Identities = 68/253 (26%), Positives = 107/253 (42%), Gaps = 25/253 (9%) Query: 9 WLLSDILGQGATANVFRGRHK---KTGDLFAIKVFNN---ISFLRPVDVQMREFEVLKKL 62 + L +LG+G VF+ R TG +FA+KV + + E +L+++ Sbjct: 20 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEV 79 Query: 63 NHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGG 122 H IV L + T LI+E+ G L+ LE E L ++ Sbjct: 80 KHPFIVDLIYAFQ--TGGKLYLILEYLSGGELFMQLEREG---IFMEDTACFYLAEISMA 134 Query: 123 MNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARE-LEDDEQFVSLYGTEEYLH 181 + HL + GI++RD+KP NIM + Q KLTDFG +E + D + GT EY+ Sbjct: 135 LGHLHQKGIIYRDLKPENIML----NHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMA 190 Query: 182 PDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 241 P++ R+ + VD WS+G Y TG+ PF E ++ + + K Sbjct: 191 PEILMRS--------GHNRAVDWWSLGALMYDMLTGAPPFTG-ENRKKTIDKILKCKLNL 241 Query: 242 PSGAISGVQKAEN 254 P + Sbjct: 242 PPYLTQEARDLLK 254 >4UYA-A nrPDB Length = 340 Score = 207 bits (527), Expect = 1e-53, Method: Composition-based stats. Identities = 68/323 (21%), Positives = 118/323 (36%), Gaps = 38/323 (11%) Query: 1 MQSTSNHL----WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPV---DVQM 53 Q + H+ L +++G G V+R + G A+K + Sbjct: 16 FQGSPVHVAFERLELKELIGAGGFGQVYRATWQ--GQEVAVKAARQDPEQDAAAAAESVR 73 Query: 54 REFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFL 113 RE + L H NI++L + + H L++EF G+L L +P + Sbjct: 74 REARLFAMLRHPNIIELRGVCLQQP--HLCLVLEFARGGALNRAL----AGRRIPPHVLV 127 Query: 114 IVLRDVVGGMNHLREN---GIVHRDIKPGNIMRVIGED----GQSVYKLTDFGAARELED 166 + GM +L E I+HRD+K NI+ + + K+TDFG ARE Sbjct: 128 NWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHR 187 Query: 167 DEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEG 226 + + G ++ P++ + ++ + D+WS GV + TG +P+R +G Sbjct: 188 TTKMAT-AGAYAWMAPEVIKSSL--------FSKGSDIWSYGVLLWELLTGEVPYRGIDG 238 Query: 227 PRRNKEV-MYKIITGKPSGAISGVQKAENGPIDWSGD-MPVSCSLSRGLQVLLTPVLANI 284 V + K+ PS K P + L + V+ + Sbjct: 239 LAVAYGVAVNKLTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQLTAIEGAVMTEM 298 Query: 285 LE---ADQEKCWGF--DQFFAET 302 + + W Q F E Sbjct: 299 PQESFHSMQDDWKLEIQQMFDEL 321 >5X8I-B nrPDB Length = 346 Score = 207 bits (527), Expect = 2e-53, Method: Composition-based stats. Identities = 68/307 (22%), Positives = 115/307 (37%), Gaps = 42/307 (13%) Query: 8 LWLLSDILGQGATANVFRGR-HKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLN--H 64 + + D LG+GA V HK G A+K+ N+ R + E +VL+ LN Sbjct: 14 RYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVD--RYCEAARSEIQVLEHLNTTD 71 Query: 65 KN----IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVV 120 N V++ E H ++ E S Y ++E + + Sbjct: 72 PNSTFRCVQMLEWFE--HHGHICIVFELL-GLSTYDFIKENG-FLPFRLDHIRKMAYQIC 127 Query: 121 GGMNHLRENGIVHRDIKPGNIMRVIGEDGQSV---------------YKLTDFGAARELE 165 +N L N + H D+KP NI+ V + ++ K+ DFG+A Sbjct: 128 KSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSAT--Y 185 Query: 166 DDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFE 225 DDE +L T Y P++ + D+WSIG G F P Sbjct: 186 DDEHHSTLVSTRHYRAPEVILAL--------GWSQPCDVWSIGCILIEYYLGFTVF-PTH 236 Query: 226 GPRRNKEVMYKIITGKPSGAISGVQKAE---NGPIDWSGDMPVSCSLSRGLQVLLTPVLA 282 + + +M +I+ P I +K + + +DW +SR + L +L+ Sbjct: 237 DSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLS 296 Query: 283 NILEADQ 289 +E ++ Sbjct: 297 QDVEHER 303 >3MV5-A nrPDB Length = 342 Score = 207 bits (526), Expect = 2e-53, Method: Composition-based stats. Identities = 57/232 (24%), Positives = 96/232 (41%), Gaps = 21/232 (9%) Query: 7 HLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNH 64 + + +LG+G V + K TG +A+K+ + +V + E VL+ H Sbjct: 10 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 69 Query: 65 KNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 124 + L + T +ME+ G L+ L E ++V ++ Sbjct: 70 PFLTALKYSFQ--THDRLCFVMEYANGGELFFHLSRER---VFSEDRARFYGAEIVSALD 124 Query: 125 HLRE-NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARE-LEDDEQFVSLYGTEEYLHP 182 +L +V+RD+K N+M D K+TDFG +E ++D + GT EYL P Sbjct: 125 YLHSEKNVVYRDLKLENLML----DKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAP 180 Query: 183 DMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVM 234 ++ E YG VD W +GV Y G LPF + + + ++ Sbjct: 181 EVLE--------DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL 224 >1UA2-A nrPDB Length = 346 Score = 207 bits (526), Expect = 2e-53, Method: Composition-based stats. Identities = 60/244 (24%), Positives = 106/244 (43%), Gaps = 27/244 (11%) Query: 7 HLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVD----VQMREFEVLKKL 62 + D LG+G A V++ R K T + AIK D +RE ++L++L Sbjct: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 Query: 63 NHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGG 122 +H NI+ L + L+ +F L ++++ N+ L S + + G Sbjct: 70 SHPNIIGLLDAF--GHKSNISLVFDFME-TDLEVIIKD--NSLVLTPSHIKAYMLMTLQG 124 Query: 123 MNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAAREL-EDDEQFVSLYGTEEYLH 181 + +L ++ I+HRD+KP N++ D V KL DFG A+ + + T Y Sbjct: 125 LEYLHQHWILHRDLKPNNLLL----DENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRA 180 Query: 182 PDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIIT-- 239 P++ A + YG VD+W++G +PF P + + + + +I Sbjct: 181 PELLFGA-------RMYGVGVDMWAVGCILAELLL-RVPFLPGD---SDLDQLTRIFETL 229 Query: 240 GKPS 243 G P+ Sbjct: 230 GTPT 233 >4H1J-A nrPDB Length = 293 Score = 207 bits (526), Expect = 2e-53, Method: Composition-based stats. Identities = 71/283 (25%), Positives = 108/283 (38%), Gaps = 28/283 (9%) Query: 3 STSNHLWLLSDILGQGATANVFRGR---HKKTGDLFAIKVFNNISFLRPVDVQMREFEVL 59 + +L+ ILG+G V+ G HK A+K L + M E ++ Sbjct: 20 GIAREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIM 79 Query: 60 KKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDV 119 K L+H +IVKL I EE T +IME P G L LE N+ L ++ + Sbjct: 80 KNLDHPHIVKLIGIIEEEPT---WIIMELYPYGELGHYLERNKNS--LKVLTLVLYSLQI 134 Query: 120 VGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEE- 178 M +L VHRDI NI+ E KL DFG +R +ED++ + + Sbjct: 135 CKAMAYLESINCVHRDIAVRNILVASPE----CVKLGDFGLSRYIEDEDYYKASVTRLPI 190 Query: 179 -YLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVMYK 236 ++ P+ + +++ D+W V + + G PF E + Sbjct: 191 KWMSPESI--------NFRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKG 242 Query: 237 IITGKPSGAISGVQKAENGPIDWSG-DMPVS----CSLSRGLQ 274 KP + D+ D P CSLS Q Sbjct: 243 DRLPKPDLCPPVLYTLMTRCWDYDPSDRPRFTELVCSLSDVYQ 285 >5KCV-A nrPDB Length = 460 Score = 207 bits (526), Expect = 2e-53, Method: Composition-based stats. Identities = 57/232 (24%), Positives = 96/232 (41%), Gaps = 21/232 (9%) Query: 7 HLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNH 64 + + +LG+G V + K TG +A+K+ + +V + E VL+ H Sbjct: 162 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 221 Query: 65 KNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 124 + L + T +ME+ G L+ L E ++V ++ Sbjct: 222 PFLTALKYSFQ--THDRLCFVMEYANGGELFFHLSRER---VFSEDRARFYGAEIVSALD 276 Query: 125 HLRE-NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARE-LEDDEQFVSLYGTEEYLHP 182 +L +V+RD+K N+M D K+TDFG +E ++D + GT EYL P Sbjct: 277 YLHSEKNVVYRDLKLENLML----DKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAP 332 Query: 183 DMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVM 234 ++ E YG VD W +GV Y G LPF + + + ++ Sbjct: 333 EVLE--------DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL 376 >4CQG-A nrPDB Length = 331 Score = 207 bits (526), Expect = 2e-53, Method: Composition-based stats. Identities = 61/237 (25%), Positives = 103/237 (43%), Gaps = 22/237 (9%) Query: 7 HLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKN 66 + L + +G G A V H TG++ AIK+ + + + E + LK L H++ Sbjct: 9 KYYELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGSDLPRVKTEIDALKSLRHQH 68 Query: 67 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 126 I +L+ + E T +++E+CP G L+ + + L E E +V R ++ + ++ Sbjct: 69 ICQLYHVLE--TKNKIFMVLEYCPGGELFDYI---ISQDRLSEEETRVVFRQILSAVAYV 123 Query: 127 RENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAAR--ELEDDEQFVSLYGTEEYLHPDM 184 G HRD+KP N++ D KL DFG + D G+ Y P++ Sbjct: 124 HSQGYAHRDLKPENLLF----DENHKLKLIDFGLCAKPKGNKDYHLQECCGSLAYAAPEL 179 Query: 185 YERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 241 + G+ D+WS+G+ Y G LPF + KI+ GK Sbjct: 180 IQGKSYL-------GSEADVWSMGILLYVLMCGFLPF----DDDNVMALYKKIMRGK 225 >4B6L-A nrPDB Length = 281 Score = 206 bits (525), Expect = 2e-53, Method: Composition-based stats. Identities = 71/289 (24%), Positives = 118/289 (40%), Gaps = 39/289 (13%) Query: 5 SNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRP--VDVQMREFEVLKKL 62 S +L +LG+G A + +TG +A+KV +P + + E E+ + L Sbjct: 7 SGRTYLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDL 66 Query: 63 NHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGG 122 H++IV+ E+ + + +E C SL + + + L E E LR ++ G Sbjct: 67 QHRHIVRFSHHFEDAD--NIYIFLELCSRKSLAHIWKAR---HTLLEPEVRYYLRQILSG 121 Query: 123 MNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQF-VSLYGTEEYLH 181 + +L + GI+HRD+K GN + K+ DFG A LE EQ ++ GT Y+ Sbjct: 122 LKYLHQRGILHRDLKLGNFFITENME----LKVGDFGLAARLEPPEQRKKTICGTPNYVA 177 Query: 182 PDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 241 P++ R + +G D+WS+G Y GS PF + Sbjct: 178 PEVLLR--------QGHGPEADVWSLGCVMYTLLCGSPPFETADLKET------------ 217 Query: 242 PSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQ--VLLTPVLANILEAD 288 K + + S +P L+ L+ P + IL D Sbjct: 218 -----YRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPSIDQILRHD 261 >3ZDU-A nrPDB Length = 325 Score = 206 bits (525), Expect = 2e-53, Method: Composition-based stats. Identities = 74/308 (24%), Positives = 124/308 (40%), Gaps = 34/308 (11%) Query: 7 HLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKN 66 ++ +G+G+ V + +HK TG + AIK+F + MRE + LK+ +H+N Sbjct: 3 EMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQFHHEN 62 Query: 67 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 126 +V L + + H L+ EF L + +GL L ++ +++L Sbjct: 63 LVNLIEVFRQKKKIH--LVFEFIDHTVLDELQH---YCHGLESKRLRKYLFQILRAIDYL 117 Query: 127 RENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELE-DDEQFVSLYGTEEYLHPDMY 185 N I+HRDIKP NI+ + KL DFG AR L + + T Y P++ Sbjct: 118 HSNNIIHRDIKPENILVSQ----SGITKLCDFGFARTLAAPGDIYDDEVATRWYRAPELV 173 Query: 186 ERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGA 245 YG VD+W++G ATG P+ + ++++KI+ + + Sbjct: 174 -------LKDTSYGKPVDIWALGCMIIEMATG----NPYLPSSSDLDLLHKIVLKVGNLS 222 Query: 246 ISGVQKAENGPIDWSGDMPVS------CSLSRGLQVLLTPVLANILEADQEKCWGFDQFF 299 PI +P L LL ++ L+ D Sbjct: 223 PHLQNIFSKSPIFAGVVLPQVQHPKNARKKYPKLNGLLADIVHACLQIDPADRIS----- 277 Query: 300 AETSDILH 307 +SD+LH Sbjct: 278 --SSDLLH 283 >3SOA-A nrPDB Length = 444 Score = 206 bits (525), Expect = 2e-53, Method: Composition-based stats. Identities = 71/274 (25%), Positives = 115/274 (41%), Gaps = 38/274 (13%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFL-RPVDVQMREFEVLKKLNHKNI 67 + L + LG+GA + V R G +A + N R RE + + L H NI Sbjct: 13 YQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDHQKLEREARICRLLKHPNI 72 Query: 68 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 127 V+L E H LI + G L+ E+ E++ ++ ++ + H Sbjct: 73 VRLHDSISEEG--HHYLIFDLVTGGELF---EDIVAREYYSEADASHCIQQILEAVLHCH 127 Query: 128 ENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQ-FVSLYGTEEYLHPDMYE 186 + G+VHR++KP N++ G + KL DFG A E+E ++Q + GT YL P++ Sbjct: 128 QMGVVHRNLKPENLLLASKLKGAA-VKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLR 186 Query: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF----------------RPFEGPRRN 230 + YG VDLW+ GV Y G PF F P + Sbjct: 187 --------KDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWD 238 Query: 231 ------KEVMYKIITGKPSGAISGVQKAENGPID 258 K+++ K++T PS I+ + ++ I Sbjct: 239 TVTPEAKDLINKMLTINPSKRITAAEALKHPWIS 272 >1CM8-A nrPDB Length = 367 Score = 206 bits (525), Expect = 2e-53, Method: Composition-based stats. Identities = 68/287 (23%), Positives = 114/287 (39%), Gaps = 29/287 (10%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVF-NNISFLRPVDVQMREFEVLKKLNHKNIVKLFAI 73 +G GA V +TG AIK RE +LK + H+N++ L + Sbjct: 33 VGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDV 92 Query: 74 EEET----TTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN 129 L+M F L +++ L E ++ ++ G+ ++ Sbjct: 93 FTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEK----LGEDRIQFLVYQMLKGLRYIHAA 147 Query: 130 GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAV 189 GI+HRD+KPGN + ED + K+ DFG AR+ D + T Y P++ Sbjct: 148 GIIHRDLKPGN--LAVNEDCE--LKILDFGLARQ--ADSEMTGYVVTRWYRAPEVI---- 197 Query: 190 LRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGA-ISG 248 + +Y TVD+WS+G TG F+ + + KE+M +TG P + Sbjct: 198 ---LNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMK--VTGTPPAEFVQR 252 Query: 249 VQKAE-NGPIDWSGDMP--VSCSLSRGLQVLLTPVLANILEADQEKC 292 +Q E + ++ S+ L +L +L D E+ Sbjct: 253 LQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQR 299 >5F9E-A nrPDB Length = 353 Score = 206 bits (524), Expect = 3e-53, Method: Composition-based stats. Identities = 64/238 (26%), Positives = 99/238 (41%), Gaps = 25/238 (10%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKL-NHK 65 + L +LG+G+ VF KKT FAIK L DV+ M E VL H Sbjct: 21 FELHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHP 80 Query: 66 NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 125 + +F T + +ME+ G L ++ + + S +++ G+ Sbjct: 81 FLTHMF--CTFQTKENLFFVMEYLNGGDLMYHIQ---SCHKFDLSRATFYAAEIILGLQF 135 Query: 126 LRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARE-LEDDEQFVSLYGTEEYLHPDM 184 L GIV+RD+K NI+ D K+ DFG +E + D + GT +Y+ P++ Sbjct: 136 LHSKGIVYRDLKLDNILL----DKDGHIKIADFGMCKENMLGDAKTNEFCGTPDYIAPEI 191 Query: 185 YERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKP 242 +KY +VD WS GV Y G PF + +E+ + I P Sbjct: 192 LLG--------QKYNHSVDWWSFGVLLYEMLIGQSPFHG----QDEEELFHSIRMDNP 237 >1VZO-A nrPDB Length = 355 Score = 205 bits (523), Expect = 4e-53, Method: Composition-based stats. Identities = 73/293 (24%), Positives = 118/293 (40%), Gaps = 26/293 (8%) Query: 7 HLWLLSDILGQGATANVFRGRH---KKTGDLFAIKVFNNISFLRPV---DVQMREFEVLK 60 + L +LG GA VF R TG L+A+KV + ++ + E +VL+ Sbjct: 54 ENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLE 113 Query: 61 KLN-HKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDV 119 + +V L + T H LI+++ G L+T L + E E I + ++ Sbjct: 114 HIRQSPFLVTLHYAFQTETKLH--LILDYINGGELFTHLSQRER---FTEHEVQIYVGEI 168 Query: 120 VGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAAREL--EDDEQFVSLYGTE 177 V + HL + GI++RDIK NI+ D LTDFG ++E ++ E+ GT Sbjct: 169 VLALEHLHKLGIIYRDIKLENILL----DSNGHVVLTDFGLSKEFVADETERAYDFCGTI 224 Query: 178 EYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKI 237 EY+ PD+ + VD WS+GV Y TG+ PF E+ +I Sbjct: 225 EYMAPDIVRG------GDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRI 278 Query: 238 ITGKPSGAISGVQKAENGPIDWSGDMPVSCSLS--RGLQVLLTPVLANILEAD 288 + +P A++ P R + + + D Sbjct: 279 LKSEPPYPQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWD 331 >4BGQ-A nrPDB Length = 304 Score = 205 bits (522), Expect = 5e-53, Method: Composition-based stats. Identities = 72/300 (24%), Positives = 129/300 (43%), Gaps = 25/300 (8%) Query: 7 HLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPV-DVQMREFEVLKKLNHK 65 + + + ++G+GA V + RHK+T ++ AIK F + V + +RE ++L+ L + Sbjct: 12 NKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQE 71 Query: 66 NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 125 NIV+L L+ E+ ++ +LEE N G+P + + ++ ++ Sbjct: 72 NIVELKEAFRRRGK--LYLVFEYVEK-NMLELLEEMPN--GVPPEKVKSYIYQLIKAIHW 126 Query: 126 LRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDE--QFVSLYGTEEYLHPD 183 +N IVHRDIKP N++ + V KL DFG AR L + + T Y P+ Sbjct: 127 CHKNDIVHRDIKPENLLISHND----VLKLCDFGFARNLSEGNNANYDEEVATRWYRSPE 182 Query: 184 MYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS 243 + A YG +VD+WS+G + G F P E + K++ PS Sbjct: 183 LLLGA--------PYGKSVDMWSVGCILGELSDGQPLF-PGESEIDQLFTIQKVLGPLPS 233 Query: 244 GAISGV-QKAENGPIDW---SGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFF 299 + + + + + L +L ++ N+L+ D + +Q Sbjct: 234 EQMKLFYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCL 293 >5AIR-A nrPDB Length = 430 Score = 205 bits (522), Expect = 6e-53, Method: Composition-based stats. Identities = 64/309 (20%), Positives = 125/309 (40%), Gaps = 32/309 (10%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIV 68 + + ++G G+ V++ + +G+L AIK L+ + RE ++++KL+H NIV Sbjct: 66 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKV-----LQDKRFKNRELQIMRKLDHCNIV 120 Query: 69 KLFAIE----EETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 124 +L E+ + L++++ P LP + + + + Sbjct: 121 RLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLA 180 Query: 125 HLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDM 184 ++ GI HRDIKP N++ + +V KL DFG+A++L E VS + Y P++ Sbjct: 181 YIHSFGICHRDIKPQNLLL---DPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPEL 237 Query: 185 YERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSG 244 A Y +++D+WS G G F G + E++ + G P+ Sbjct: 238 IFGAT-------DYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIK--VLGTPTR 288 Query: 245 AISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTP----VLANILEADQEKCWGF----- 295 +++ ++ + ++ + P + + +LE Sbjct: 289 EQ--IREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACA 346 Query: 296 DQFFAETSD 304 FF E D Sbjct: 347 HSFFDELRD 355 >6DTL-A nrPDB Length = 364 Score = 205 bits (521), Expect = 6e-53, Method: Composition-based stats. Identities = 57/286 (19%), Positives = 105/286 (36%), Gaps = 24/286 (8%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLR-PVDVQMREFEVLKKLNHKNIVKLFAI 73 +G+GA V + +T + AIK N + +RE ++L+ ++H+NIV + I Sbjct: 38 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 97 Query: 74 EEET---TTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 130 + E L+ ++ + L E L ++ G+ ++ Sbjct: 98 IPPPLRNAFNDVYIAYELMD-TDLHQIIR---SNQALSEEHCQYFLYQILRGLKYIHSAN 153 Query: 131 IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVL 190 ++HRD+KP N++ D K+ DFG AR + + T Y P++ Sbjct: 154 VLHRDLKPSNLLLNANCD----LKICDFGLARVTSESDFMTEYVVTRWYRAPELL----- 204 Query: 191 RKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQ 250 + Y A +D+WS+G F F + + + +M I G PS Sbjct: 205 --LNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELI--GTPSEEELEFL 260 Query: 251 KAENGP-IDWSGDMPVSCSLSR--GLQVLLTPVLANILEADQEKCW 293 I P + + L ++ +L D + Sbjct: 261 NENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRI 306 >4AT3-A nrPDB Length = 299 Score = 205 bits (521), Expect = 6e-53, Method: Composition-based stats. Identities = 65/286 (22%), Positives = 109/286 (38%), Gaps = 42/286 (14%) Query: 1 MQSTSNHLWLLSDILGQGATANVFRGRH-----KKTGDLFAIKVFNNISFLRPVDVQMRE 55 +Q H +L LG+GA VF ++ L A+K + S D RE Sbjct: 7 VQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKD-FHRE 65 Query: 56 FEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLE----------EPSNAY 105 E+L L H++IVK + + E +++ E+ G L L E + Sbjct: 66 AELLTNLQHEHIVKFYGVCVEGDP--LIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPT 123 Query: 106 GLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELE 165 L +S+ L + + + GM +L VHRD+ N + + K+ DFG +R++ Sbjct: 124 ELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVG----ENLLVKIGDFGMSRDVY 179 Query: 166 DDEQFVSLYGT---EEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPF 221 + + T ++ P+ +K+ D+WS+GV + T G P+ Sbjct: 180 STDYYRVGGHTMLPIRWMPPESIM--------YRKFTTESDVWSLGVVLWEIFTYGKQPW 231 Query: 222 RPFEGPRRNKEVMYKIITG----KPSGAISGVQKAENGPIDWSGDM 263 N EV+ I G +P V + G M Sbjct: 232 YQL----SNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHM 273 >6E2O-A nrPDB Length = 295 Score = 205 bits (521), Expect = 7e-53, Method: Composition-based stats. Identities = 67/241 (27%), Positives = 99/241 (41%), Gaps = 16/241 (6%) Query: 14 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAI 73 +LG+G V+ GR AIK R E + K L HKNIV+ Sbjct: 29 VLGKGTYGIVYAGRDLSNQVRIAIKEI-PERDSRYSQPLHEEIALHKHLKHKNIVQYLGS 87 Query: 74 EEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVH 133 E + ME P GSL +L E + ++ G+ +L +N IVH Sbjct: 88 FSE--NGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVH 145 Query: 134 RDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFV-SLYGTEEYLHPDMYERAVLRK 192 RDIK N++ V K++DFG ++ L + GT +Y+ P++ ++ Sbjct: 146 RDIKGDNVLINTY---SGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGP--- 199 Query: 193 DHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKA 252 + YG D+WS+G T ATG PF P + M+K+ K I A Sbjct: 200 ---RGYGKAADIWSLGCTIIEMATGKPPFYELGEP---QAAMFKVGMFKVHPEIPESMSA 253 Query: 253 E 253 E Sbjct: 254 E 254 >4ZSG-A nrPDB Length = 347 Score = 205 bits (521), Expect = 7e-53, Method: Composition-based stats. Identities = 60/306 (19%), Positives = 109/306 (35%), Gaps = 31/306 (10%) Query: 3 STSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVF-NNISFLRPVDVQMREFEVLKK 61 + + + +G GA V R + TG AIK N + +RE ++LK Sbjct: 3 FDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKH 62 Query: 62 LNHKNIVKLFAIEEETTT----RHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLR 117 H NI+ + I T + ++++ L+ ++ ++ L L Sbjct: 63 FKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMES-DLHQIIH---SSQPLTLEHVRYFLY 118 Query: 118 DVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAAREL-----EDDEQFVS 172 ++ G+ ++ ++HRD+KP N++ + K+ DFG AR L E Sbjct: 119 QLLRGLKYMHSAQVIHRDLKPSNLLV----NENCELKIGDFGMARGLCTSPAEHQYFMTE 174 Query: 173 LYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKE 232 T Y P++ +Y +DLWS+G F F + + Sbjct: 175 YVATRWYRAPELMLSL-------HEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQL 227 Query: 233 VMYKIITGKPSGAISGVQKAENGP--IDWSGDMPVSC--SLSRGLQVLLTPVLANILEAD 288 +M ++ G PS A+ AE I ++ G +L +L + Sbjct: 228 IM--MVLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFE 285 Query: 289 QEKCWG 294 Sbjct: 286 PSARIS 291 >3OHT-A nrPDB Length = 389 Score = 204 bits (520), Expect = 9e-53, Method: Composition-based stats. Identities = 66/303 (21%), Positives = 117/303 (38%), Gaps = 29/303 (9%) Query: 7 HLWLLSDILGQGATANVFRGRHKKTGDLFAIKVF-NNISFLRPVDVQMREFEVLKKLNHK 65 + +G GA +V K+G A+K + RE +LK + H+ Sbjct: 51 ERYQTLSPVGSGAYGSVCSSYDVKSGLKIAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 110 Query: 66 NIVKLFAIEEETTTRH----KVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVG 121 N++ L + T+ L+ L +++ L + ++ ++ Sbjct: 111 NVIGLLDVFTPATSLEEFNDVYLVTHLM-GADLNNIVK----CQKLTDDHVQFLIYQILR 165 Query: 122 GMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLH 181 G+ ++ I+HRD+KP N + ED + K+ DFG AR D++ T Y Sbjct: 166 GLKYIHSADIIHRDLKPSN--LAVNEDCE--LKILDFGLAR--HTDDEMTGYVATRWYRA 219 Query: 182 PDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 241 P++ + Y TVD+WS+G TG F + + +++M +TG Sbjct: 220 PEIM-------LNWMHYNMTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMR--LTGT 270 Query: 242 PSGA-ISGVQKAE-NGPIDWSGDMPVSC--SLSRGLQVLLTPVLANILEADQEKCWGFDQ 297 P + IS + E I+ MP + G L +L +L D +K + Sbjct: 271 PPASVISRMPSHEARNYINSLPQMPKRNFADVFIGANPLAVDLLEKMLVLDTDKRITASE 330 Query: 298 FFA 300 A Sbjct: 331 ALA 333 >5DBX-A nrPDB Length = 328 Score = 204 bits (520), Expect = 1e-52, Method: Composition-based stats. Identities = 63/259 (24%), Positives = 112/259 (43%), Gaps = 28/259 (10%) Query: 6 NHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHK 65 + L +++G GATA V K + AIK N +D ++E + + + +H Sbjct: 10 RDAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQCSHP 69 Query: 66 NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVL-----EEPSNAYGLPESEFLIVLRDVV 120 N+V + L+M+ GS+ ++ L E+ +L++V+ Sbjct: 70 NVVTYYTSF--VVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVL 127 Query: 121 GGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFV------SLY 174 G+++L NG +HRD+K GNI+ GEDG ++ DFG + L Sbjct: 128 EGLDYLHRNGQIHRDLKAGNILL--GEDGS--VQIADFGVSAFLATGGDVTRNKVRKDFV 183 Query: 175 GTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVM 234 GT ++ P++ E+ + Y D+WS G+T ATG+ P+ + + V+ Sbjct: 184 GTPCWMAPEVMEQV-------RGYDFKADMWSFGITAIELATGAAPYHKYPPMK----VL 232 Query: 235 YKIITGKPSGAISGVQKAE 253 + P +GV+ E Sbjct: 233 MLTLQNDPPTLETGVEDKE 251 >3TKU-A nrPDB Length = 433 Score = 204 bits (520), Expect = 1e-52, Method: Composition-based stats. Identities = 62/257 (24%), Positives = 111/257 (43%), Gaps = 15/257 (5%) Query: 6 NHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDV--QMREFEVLKKLN 63 + + ++G+GA V + K T ++A+K+ N L+ + E +VL + Sbjct: 89 REDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGD 148 Query: 64 HKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 123 + I L ++ H L+M++ G L T+L + + LPE + ++V + Sbjct: 149 CQWITALHYAFQDEN--HLYLVMDYYVGGDLLTLLSKFED--KLPEDMARFYIGEMVLAI 204 Query: 124 NHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLY--GTEEYLH 181 + + + VHRDIKP N++ D +L DFG+ ++ DD S GT +Y+ Sbjct: 205 DSIHQLHYVHRDIKPDNVLL----DVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYIS 260 Query: 182 PDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 241 P++ + +D KYG D WS+GV Y G PF ++M + Sbjct: 261 PEILQAM---EDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQ 317 Query: 242 PSGAISGVQKAENGPID 258 ++ V + I Sbjct: 318 FPSHVTDVSEEAKDLIQ 334 >6BDL-A nrPDB Length = 347 Score = 204 bits (519), Expect = 1e-52, Method: Composition-based stats. Identities = 56/232 (24%), Positives = 106/232 (45%), Gaps = 20/232 (8%) Query: 9 WLLSDILGQGATANVFRGRHK-KTGDLFAIKVFNNISF--LRPVDVQMREFEVLKKLNHK 65 + + D LG G V + K + FA+K+ R + E ++++ + Sbjct: 36 FNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSD 95 Query: 66 NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 125 IV+L+ +++ ++ ++ME C G L+T+L + + +S VV + Sbjct: 96 FIVRLYRTFKDS--KYLYMLMEACLGGELWTILRDRGS---FEDSTTRFYTACVVEAFAY 150 Query: 126 LRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMY 185 L GI++RD+KP N++ D + KL DFG A+++ ++ + GT EY+ P++ Sbjct: 151 LHSKGIIYRDLKPENLIL----DHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEII 206 Query: 186 ERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKI 237 K + + D WS+G+ Y TGS PF + + ++ I Sbjct: 207 L--------NKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGI 250 >3PFQ-A nrPDB Length = 674 Score = 204 bits (519), Expect = 1e-52, Method: Composition-based stats. Identities = 54/227 (23%), Positives = 97/227 (42%), Gaps = 21/227 (9%) Query: 14 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKK-LNHKNIVKL 70 +LG+G+ V K T +L+A+K+ ++ DV+ M E VL + +L Sbjct: 348 VLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQL 407 Query: 71 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 130 + + T +ME+ G L +++ E + ++ G+ L+ G Sbjct: 408 HSCFQ--TMDRLYFVMEYVNGGDLMYHIQQVGR---FKEPHAVFYAAEIAIGLFFLQSKG 462 Query: 131 IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARE-LEDDEQFVSLYGTEEYLHPDMYERAV 189 I++RD+K N+M D + K+ DFG +E + D + GT +Y+ P++ Sbjct: 463 IIYRDLKLDNVML----DSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA--- 515 Query: 190 LRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYK 236 + YG +VD W+ GV Y G PF + + +M Sbjct: 516 -----YQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEH 557 >6NPU-A nrPDB Length = 298 Score = 204 bits (519), Expect = 1e-52, Method: Composition-based stats. Identities = 58/291 (19%), Positives = 108/291 (37%), Gaps = 31/291 (10%) Query: 1 MQSTSN-HLWLLSDI-------LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ 52 Q + N W + LG G V+ G KK A+K + V+ Sbjct: 12 FQGSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTM--EVEEF 69 Query: 53 MREFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEF 112 ++E V+K++ H N+V+L + +I EF G+L L E N + Sbjct: 70 LKEAAVMKEIKHPNLVQLLGVCTREPP--FYIITEFMTYGNLLDYLRE-CNRQEVNAVVL 126 Query: 113 LIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVS 172 L + + M +L + +HRD+ N + + K+ DFG +R + D + + Sbjct: 127 LYMATQISSAMEYLEKKNFIHRDLAARNCLVGENH----LVKVADFGLSRLMTGD-TYTA 181 Query: 173 LYGTE---EYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPR 228 G + ++ P+ K+ D+W+ GV + AT G P+ + + Sbjct: 182 HAGAKFPIKWTAPE--------SLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQ 233 Query: 229 RNKEVMYKIITGKPSGAISGVQKAENGPIDWSG-DMPVSCSLSRGLQVLLT 278 + + +P G V + W+ D P + + + + Sbjct: 234 VYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQ 284 >4BBM-A nrPDB Length = 331 Score = 204 bits (519), Expect = 1e-52, Method: Composition-based stats. Identities = 72/297 (24%), Positives = 111/297 (37%), Gaps = 24/297 (8%) Query: 1 MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKV-FNNISFLRPVDVQMREFEVL 59 QS + ++G+G+ V + R+K TG + AIK + + MRE ++L Sbjct: 21 FQSM--EKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLL 78 Query: 60 KKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDV 119 K+L H+N+V L + + L+ EF L + GL L + Sbjct: 79 KQLRHENLVNLLEVC--KKKKRWYLVFEFVDHTILDDL---ELFPNGLDYQVVQKYLFQI 133 Query: 120 VGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAAREL-EDDEQFVSLYGTEE 178 + G+ + I+HRDIKP NI+ V KL DFG AR L E + T Sbjct: 134 INGIGFCHSHNIIHRDIKPENILVSQ----SGVVKLCDFGFARTLAAPGEVYDDEVATRW 189 Query: 179 YLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKII 238 Y P++ V KYG VD+W+IG G F + +M + Sbjct: 190 YRAPELLVGDV-------KYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLG 242 Query: 239 TGKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANI---LEADQEKC 292 P + + ++ L R L V+ L D +K Sbjct: 243 NLIPRHQELFNKNPVFAGVR-LPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKR 298 >5D7A-A nrPDB Length = 308 Score = 204 bits (519), Expect = 1e-52, Method: Composition-based stats. Identities = 60/224 (26%), Positives = 108/224 (48%), Gaps = 16/224 (7%) Query: 3 STSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKL 62 ++ L +++G G V++GRH KTG L AIKV + + +E +LKK Sbjct: 13 RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMD--VTGDEEEEIKQEINMLKKY 70 Query: 63 -NHKNIVKLFAIEEETTT----RHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLR 117 +H+NI + + L+MEFC GS+ ++ + + L E + R Sbjct: 71 SHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLI-KNTKGNTLKEEWIAYICR 129 Query: 118 DVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD-EQFVSLYGT 176 +++ G++HL ++ ++HRDIK N++ + KL DFG + +L+ + + GT Sbjct: 130 EILRGLSHLHQHKVIHRDIKGQNVLLTENAE----VKLVDFGVSAQLDRTVGRRNTFIGT 185 Query: 177 EEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLP 220 ++ P++ ++ Y DLWS+G+T A G+ P Sbjct: 186 PYWMAPEVI---ACDENPDATYDFKSDLWSLGITAIEMAEGAPP 226 >4P5Q-A nrPDB Length = 361 Score = 204 bits (518), Expect = 1e-52, Method: Composition-based stats. Identities = 57/272 (20%), Positives = 108/272 (39%), Gaps = 17/272 (6%) Query: 11 LSDILGQGATANVFRGRHKKTGDL---FAIKVFNNISFLRPVDVQMREFEVLKKLNHKNI 67 + ++G G V GR K AIK + + E ++ + +H NI Sbjct: 37 IDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNI 96 Query: 68 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 127 ++L + ++ + +++ E+ GSL + L + + + + + +LR + GM +L Sbjct: 97 IRLEGVVTKS--KPVMIVTEYMENGSLDSFLRKHDAQFTV--IQLVGMLRGIASGMKYLS 152 Query: 128 ENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYER 187 + G VHRD+ NI+ + V K++DFG +R LEDD + + Y T P Sbjct: 153 DMGYVHRDLAARNILI----NSNLVCKVSDFGLSRVLEDDPE--AAYTTRGGKIP--IRW 204 Query: 188 AVLRKDHQKKYGATVDLWSIGVTFYH-AATGSLPFRPFEGPRRNKEVMYKIITGKPSGAI 246 +K+ + D+WS G+ + + G P+ K V P Sbjct: 205 TSPEAIAYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCP 264 Query: 247 SGVQKAENGPIDWSG-DMPVSCSLSRGLQVLL 277 + + + + P + L L+ Sbjct: 265 AALYQLMLDCWQKDRNNRPKFEQIVSILDKLI 296 >4UZD-A nrPDB Length = 287 Score = 204 bits (518), Expect = 1e-52, Method: Composition-based stats. Identities = 68/290 (23%), Positives = 120/290 (41%), Gaps = 38/290 (13%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRP-VDVQMR-EFEVLKKLNHKN 66 + + LG+G NV+ R K++ + A+KV + V+ Q+R E E+ L H N Sbjct: 10 FEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPN 69 Query: 67 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 126 I++L+ + T LI+E+ P G++Y L++ S E + ++ +++ Sbjct: 70 ILRLYGYFHDATR--VYLILEYAPLGTVYRELQKLSK---FDEQRTATYITELANALSYC 124 Query: 127 RENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYE 186 ++HRDIKP N++ K+ DFG + + +L GT +YL P+M E Sbjct: 125 HSKRVIHRDIKPENLLLG----SAGELKIADFGWSVH-APSSRRTTLCGTLDYLPPEMIE 179 Query: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF------------------RPFEGPR 228 + + VDLWS+GV Y G PF P Sbjct: 180 G--------RMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTE 231 Query: 229 RNKEVMYKIITGKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLT 278 ++++ +++ PS + E+ I + P +C L Sbjct: 232 GARDLISRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESAAAALE 281 >6FD3-A nrPDB Length = 300 Score = 204 bits (518), Expect = 2e-52, Method: Composition-based stats. Identities = 55/220 (25%), Positives = 97/220 (44%), Gaps = 20/220 (9%) Query: 3 STSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKL 62 + + +GQGA+ V+ TG AIK N + ++ + E V+++ Sbjct: 18 GDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKK-ELIINEILVMREN 76 Query: 63 NHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGG 122 + NIV ++ME+ GSL V+ E + E + V R+ + Sbjct: 77 KNPNIVNYLDSYL--VGDELWVVMEYLAGGSLTDVVTETC----MDEGQIAAVCRECLQA 130 Query: 123 MNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDE-QFVSLYGTEEYLH 181 ++ L N ++HRDIK NI+ + KLTDFG ++ ++ + ++ GT ++ Sbjct: 131 LDFLHSNQVIHRDIKSDNILLGMD----GSVKLTDFGFCAQITPEQSKRSTMVGTPYWMA 186 Query: 182 PDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 P++ R K YG VD+WS+G+ G P+ Sbjct: 187 PEVVTR--------KAYGPKVDIWSLGIMAIEMVEGEPPY 218 >5MJB-A nrPDB Length = 305 Score = 203 bits (517), Expect = 2e-52, Method: Composition-based stats. Identities = 56/280 (20%), Positives = 111/280 (39%), Gaps = 28/280 (10%) Query: 7 HLWLLSDILGQGATANVFRGRHKKTGDL---FAIKVFNNISFLRPVDVQMREFEVLKKLN 63 + +++G G V++GR K G AIK + + E ++ + + Sbjct: 26 SFVKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFD 85 Query: 64 HKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 123 H+NI++L + ++ R ++I EF +L + L + + + + + +LR + GM Sbjct: 86 HRNIIRLEGVVTKS--RPVMIITEFMENCALDSFLRQNDGQFTV--IQLVGMLRGIAAGM 141 Query: 124 NHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELED---DEQFVSLYGTE--- 177 +L E VHRD+ NI+ + V K++DFG +R L+D D + S G + Sbjct: 142 KYLSEMNYVHRDLAARNILV----NSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPV 197 Query: 178 EYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVMYK 236 + P+ +K+ + D+WS G+ + + G P+ + Sbjct: 198 RWTAPEAIA--------YRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQD 249 Query: 237 IITGKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVL 276 P + + + W D + + L Sbjct: 250 YRLPPPMDCPAALHQLMLDC--WQKDRNSRPRFAEIVNTL 287 >6CMJ-A nrPDB Length = 321 Score = 203 bits (516), Expect = 2e-52, Method: Composition-based stats. Identities = 67/292 (22%), Positives = 121/292 (41%), Gaps = 44/292 (15%) Query: 7 HLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLR----------PVDVQMREF 56 + L D +G+G+ V ++ +A+KV + +R P++ +E Sbjct: 34 DQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGGCIQPRGPIEQVYQEI 93 Query: 57 EVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVL 116 +LKKL+H N+VKL + ++ H ++ E G + V L E + Sbjct: 94 AILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEV----PTLKPLSEDQARFYF 149 Query: 117 RDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELE-DDEQFVSLYG 175 +D++ G+ +L I+HRDIKP N++ +GEDG K+ DFG + E + D + G Sbjct: 150 QDLIKGIEYLHYQKIIHRDIKPSNLL--VGEDG--HIKIADFGVSNEFKGSDALLSNTVG 205 Query: 176 TEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF-------------- 221 T ++ P+ G +D+W++GVT Y G PF Sbjct: 206 TPAFMAPESLSETRKIFS-----GKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKS 260 Query: 222 RPFEGPR------RNKEVMYKIITGKPSGAISGVQKAENGPIDWSGDMPVSC 267 + E P K+++ +++ P I + + + G P+ Sbjct: 261 QALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPS 312 >2I0E-A nrPDB Length = 353 Score = 203 bits (516), Expect = 3e-52, Method: Composition-based stats. Identities = 54/227 (23%), Positives = 97/227 (42%), Gaps = 21/227 (9%) Query: 14 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKK-LNHKNIVKL 70 +LG+G+ V K T +L+A+K+ ++ DV+ M E VL + +L Sbjct: 27 VLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQL 86 Query: 71 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 130 + + T +ME+ G L +++ E + ++ G+ L+ G Sbjct: 87 HSCFQ--TMDRLYFVMEYVNGGDLMYHIQQVGR---FKEPHAVFYAAEIAIGLFFLQSKG 141 Query: 131 IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARE-LEDDEQFVSLYGTEEYLHPDMYERAV 189 I++RD+K N+M D + K+ DFG +E + D + GT +Y+ P++ Sbjct: 142 IIYRDLKLDNVML----DSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA--- 194 Query: 190 LRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYK 236 + YG +VD W+ GV Y G PF + + +M Sbjct: 195 -----YQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEH 236 >4XEY-B nrPDB Length = 408 Score = 203 bits (516), Expect = 3e-52, Method: Composition-based stats. Identities = 55/274 (20%), Positives = 104/274 (37%), Gaps = 23/274 (8%) Query: 10 LLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVK 69 + LG G V+ G KK A+K + V+ ++E V+K++ H N+V+ Sbjct: 128 TMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTM--EVEEFLKEAAVMKEIKHPNLVQ 185 Query: 70 LFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN 129 L + +I EF G+L L E N + L + + M +L + Sbjct: 186 LLGVCTREPP--FYIITEFMTYGNLLDYLRE-CNRQEVNAVVLLYMATQISSAMEYLEKK 242 Query: 130 GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTE---EYLHPDMYE 186 +HRD+ N + + K+ DFG +R + D + + G + ++ P+ Sbjct: 243 NFIHRDLAARNCLVGENH----LVKVADFGLSRLMTGD-TYTAHAGAKFPIKWTAPE--- 294 Query: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVMYKIITGKPSGA 245 K+ D+W+ GV + AT G P+ + + + + +P G Sbjct: 295 -----SLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGC 349 Query: 246 ISGVQKAENGPIDWSG-DMPVSCSLSRGLQVLLT 278 V + W+ D P + + + + Sbjct: 350 PEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQ 383 >5L6P-A nrPDB Length = 298 Score = 203 bits (516), Expect = 3e-52, Method: Composition-based stats. Identities = 59/272 (21%), Positives = 106/272 (38%), Gaps = 15/272 (5%) Query: 11 LSDILGQGATANVFRGRHKKTGDL---FAIKVFNNISFLRPVDVQMREFEVLKKLNHKNI 67 + +++G G V RGR K+ G AIK R + E ++ + +H NI Sbjct: 23 IEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQRRDFLSEASIMGQFDHPNI 82 Query: 68 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 127 ++L + ++ R +++ EF +L + L N + + +LR + GM +L Sbjct: 83 IRLEGVVTKS--RPVMILTEFMENCALDSFLR--LNDGQFTVIQLVGMLRGIAAGMKYLS 138 Query: 128 ENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYER 187 E VHRD+ NI+ + V K++DFG +R LEDD + + P Sbjct: 139 EMNYVHRDLAARNILV----NSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIP--IRW 192 Query: 188 AVLRKDHQKKYGATVDLWSIGVTFYH-AATGSLPFRPFEGPRRNKEVMYKIITGKPSGAI 246 +K+ + D+WS G+ + + G P+ V P Sbjct: 193 TAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVEQDYRLPPPMDCP 252 Query: 247 SGV-QKAENGPIDWSGDMPVSCSLSRGLQVLL 277 + + Q + + P + L L+ Sbjct: 253 TALHQLMLDCWVRDRNLRPKFSQIVNTLDKLI 284 >2XYN-A nrPDB Length = 292 Score = 203 bits (516), Expect = 3e-52, Method: Composition-based stats. Identities = 56/273 (20%), Positives = 103/273 (37%), Gaps = 23/273 (8%) Query: 10 LLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVK 69 + LG G V+ G KK A+K + V+ ++E V+K++ H N+V+ Sbjct: 35 TMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTM--EVEEFLKEAAVMKEIKHPNLVQ 92 Query: 70 LFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN 129 L + T ++ E+ P G+L L E N + L + + M +L + Sbjct: 93 LLGVC--TLEPPFYIVTEYMPYGNLLDYLRE-CNREEVTAVVLLYMATQISSAMEYLEKK 149 Query: 130 GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTE---EYLHPDMYE 186 +HRD+ N + V K+ DFG +R + D + + G + ++ P+ Sbjct: 150 NFIHRDLAARNCLVGENH----VVKVADFGLSRLMTGD-TYTAHAGAKFPIKWTAPE--- 201 Query: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVMYKIITGKPSGA 245 + D+W+ GV + AT G P+ + + + +P G Sbjct: 202 -----SLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGC 256 Query: 246 ISGVQKAENGPIDWSG-DMPVSCSLSRGLQVLL 277 V + WS D P + + + Sbjct: 257 PPKVYELMRACWKWSPADRPSFAETHQAFETMF 289 >2FO0-A nrPDB Length = 495 Score = 203 bits (516), Expect = 3e-52, Method: Composition-based stats. Identities = 54/274 (19%), Positives = 104/274 (37%), Gaps = 23/274 (8%) Query: 10 LLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVK 69 + LG G V+ G KK A+K + V+ ++E V+K++ H N+V+ Sbjct: 220 TMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTM--EVEEFLKEAAVMKEIKHPNLVQ 277 Query: 70 LFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN 129 L + +I EF G+L L E N + L + + M +L + Sbjct: 278 LLGVCTREPP--FYIITEFMTYGNLLDYLRE-CNRQEVNAVVLLYMATQISSAMEYLEKK 334 Query: 130 GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTE---EYLHPDMYE 186 +HR++ N + + K+ DFG +R + D + + G + ++ P+ Sbjct: 335 NFIHRNLAARNCLVGENH----LVKVADFGLSRLMTGD-TYTAHAGAKFPIKWTAPE--- 386 Query: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVMYKIITGKPSGA 245 K+ D+W+ GV + AT G P+ + + + + +P G Sbjct: 387 -----SLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGC 441 Query: 246 ISGVQKAENGPIDWSG-DMPVSCSLSRGLQVLLT 278 V + W+ D P + + + + Sbjct: 442 PEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQ 475 >2BRG-A nrPDB Length = 297 Score = 203 bits (516), Expect = 3e-52, Method: Composition-based stats. Identities = 60/232 (25%), Positives = 105/232 (45%), Gaps = 20/232 (8%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIV 68 W L LG+GA V ++ T + A+K+ + + + +E + K LNH+N+V Sbjct: 9 WDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVV 68 Query: 69 KLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE 128 K + E ++ L E+C G L+ +E G+PE + ++ G+ +L Sbjct: 69 KFYGHRREGNIQYLFL--EYCSGGELFDRIE---PDIGMPEPDAQRFFHQLMAGVVYLHG 123 Query: 129 NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQ---FVSLYGTEEYLHPDMY 185 GI HRDIKP N++ D + K++DFG A + + + GT Y+ P++ Sbjct: 124 IGITHRDIKPENLLL----DERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELL 179 Query: 186 ERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF-RPFEGPRRNKEVMYK 236 +R + VD+WS G+ G LP+ +P + + + K Sbjct: 180 KRREF-------HAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEK 224 >4FZF-B nrPDB Length = 283 Score = 202 bits (515), Expect = 3e-52, Method: Composition-based stats. Identities = 65/301 (21%), Positives = 125/301 (41%), Gaps = 34/301 (11%) Query: 3 STSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKL 62 + L+ + +G+G+ VF+G +T + AIK+ + ++ +E VL + Sbjct: 4 ADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQC 63 Query: 63 NHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGG 122 + + K + + + +IME+ GS +L A E + +L++++ G Sbjct: 64 DSSYVTKYYGSYLKGSK--LWIIMEYLGGGSALDLLR----AGPFDEFQIATMLKEILKG 117 Query: 123 MNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDE-QFVSLYGTEEYLH 181 +++L +HRDIK N++ D KL FG A +L D + + + GT ++ Sbjct: 118 LDYLHSEKKIHRDIKAANVLLSEQGD----VKLAAFGVAGQLTDTQIKRNTFVGTPFWMA 173 Query: 182 PDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 241 P++ +++ Y + D+WS+G+T A G P R V++ I Sbjct: 174 PEVIQQSA--------YDSKADIWSLGITAIELAKGEPPNSDMHPMR----VLFLIPKNN 221 Query: 242 PSGAISGVQKAENGPIDWSGDM-PVSCSLSRGL--------QVLLTPVLANILEADQEKC 292 P + K+ ID + P ++ L T L ++ D+ K Sbjct: 222 PPTLVGDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELI--DRFKR 279 Query: 293 W 293 W Sbjct: 280 W 280 >4AW2-A nrPDB Length = 437 Score = 202 bits (515), Expect = 3e-52, Method: Composition-based stats. Identities = 62/257 (24%), Positives = 110/257 (42%), Gaps = 15/257 (5%) Query: 6 NHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDV--QMREFEVLKKLN 63 + + ++G+GA V + K +FA+K+ N L+ + E +VL + Sbjct: 73 REDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGD 132 Query: 64 HKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 123 K I L ++ + L+M++ G L T+L + + LPE L ++V + Sbjct: 133 SKWITTLHYAFQDDN--NLYLVMDYYVGGDLLTLLSKFEDR--LPEEMARFYLAEMVIAI 188 Query: 124 NHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLY--GTEEYLH 181 + + + VHRDIKP NI+ D +L DFG+ +L +D S GT +Y+ Sbjct: 189 DSVHQLHYVHRDIKPDNILM----DMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYIS 244 Query: 182 PDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 241 P++ + + + +YG D WS+GV Y G PF ++M + Sbjct: 245 PEILQAM---EGGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQ 301 Query: 242 PSGAISGVQKAENGPID 258 ++ V + I Sbjct: 302 FPTQVTDVSENAKDLIR 318 >3DB8-A nrPDB Length = 317 Score = 202 bits (515), Expect = 4e-52, Method: Composition-based stats. Identities = 58/219 (26%), Positives = 95/219 (43%), Gaps = 20/219 (9%) Query: 7 HLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQM--REFEVLKKLNH 64 ++ LG+G A + T ++FA KV L+P + E + K L++ Sbjct: 42 KRYMRGRFLGKGGFAKCYEITDMDTKEVFAGKVVPKSMLLKPHQKEKMSTEIAIHKSLDN 101 Query: 65 KNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 124 ++V E+ +++E C SL LE + E E +R + G+ Sbjct: 102 PHVVGFHGFFED--DDFVYVVLEICRRRSL---LELHKRRKAVTEPEARYFMRQTIQGVQ 156 Query: 125 HLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELE-DDEQFVSLYGTEEYLHPD 183 +L N ++HRD+K GN+ D K+ DFG A ++E D E+ L GT Y+ P+ Sbjct: 157 YLHNNRVIHRDLKLGNLFLNDDMD----VKIGDFGLATKIEFDGERKKDLCGTPNYIAPE 212 Query: 184 MYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFR 222 + +K + VD+WS+G Y G PF Sbjct: 213 VL--------CKKGHSFEVDIWSLGCILYTLLVGKPPFE 243 >2Y6O-A nrPDB Length = 291 Score = 202 bits (513), Expect = 5e-52, Method: Composition-based stats. Identities = 59/276 (21%), Positives = 107/276 (38%), Gaps = 25/276 (9%) Query: 11 LSDILGQGATANVFRGRHKKTGDL---FAIKVFNNISFLRPVDVQMREFEVLKKLNHKNI 67 + ++G G V GR K G AIK + + E ++ + +H NI Sbjct: 18 IEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHPNI 77 Query: 68 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 127 + L + T + ++I E+ GSL L + + + + + +LR + GM +L Sbjct: 78 IHLEGVV--TKCKPVMIITEYMENGSLDAFLRKNDGRFTV--IQLVGMLRGIGSGMKYLS 133 Query: 128 ENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQ--FVSLYG--TEEYLHPD 183 + VHRD+ NI+ + V K++DFG +R LEDD + + + G + P+ Sbjct: 134 DMSYVHRDLAARNILV----NSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPE 189 Query: 184 MYERAVLRKDHQKKYGATVDLWSIGVTFYH-AATGSLPFRPFEGPRRNKEVMYKIITGKP 242 +K+ + D+WS G+ + + G P+ K + P Sbjct: 190 AIA--------YRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPP 241 Query: 243 SGAISGV-QKAENGPIDWSGDMPVSCSLSRGLQVLL 277 + Q + D P + L L+ Sbjct: 242 MDCPIALHQLMLDCWQKERSDRPKFGQIVNMLDKLI 277 >2R2P-A nrPDB Length = 295 Score = 202 bits (513), Expect = 5e-52, Method: Composition-based stats. Identities = 59/277 (21%), Positives = 111/277 (40%), Gaps = 25/277 (9%) Query: 10 LLSDILGQGATANVFRGRHKKTGDL---FAIKVFNNISFLRPVDVQMREFEVLKKLNHKN 66 + ++G G V GR K G AIK + + E ++ + +H N Sbjct: 25 TIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPN 84 Query: 67 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 126 I+ L + ++ + +++ E+ GSL T L++ + + + + +LR + GM +L Sbjct: 85 IIHLEGVVTKS--KPVMIVTEYMENGSLDTFLKKNDGQFTV--IQLVGMLRGISAGMKYL 140 Query: 127 RENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQ--FVSLYG--TEEYLHP 182 + G VHRD+ NI+ + V K++DFG +R LEDD + + + G + P Sbjct: 141 SDMGYVHRDLAARNILI----NSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAP 196 Query: 183 DMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVMYKIITGK 241 + +K+ + D+WS G+ + + G P+ K V Sbjct: 197 EAIA--------FRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPS 248 Query: 242 PSGAISGV-QKAENGPIDWSGDMPVSCSLSRGLQVLL 277 P + + Q + P + L L+ Sbjct: 249 PMDCPAALYQLMLDCWQKERNSRPKFDEIVNMLDKLI 285 >2F9G-A nrPDB Length = 353 Score = 202 bits (513), Expect = 5e-52, Method: Composition-based stats. Identities = 61/305 (20%), Positives = 114/305 (37%), Gaps = 39/305 (12%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIV 68 + L +LG+GA V HK TG++ AIK +RE ++LK H+NI+ Sbjct: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENII 72 Query: 69 KLFAIEEETTTRH---KVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 125 +F I+ + + +I E T L + L + + + + Sbjct: 73 TIFNIQRPDSFENFNEVYIIQELM-----QTDLHRVISTQMLSDDHIQYFIYQTLRAVKV 127 Query: 126 LRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQ-----------FVSLY 174 L + ++HRD+KP N++ D K+ DFG AR +++ Sbjct: 128 LHGSNVIHRDLKPSNLLINSNCD----LKVCDFGLARIIDESAADNSEPTGQQSGMTEYV 183 Query: 175 GTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVM 234 T Y P++ + KY +D+WS G F + R++ ++ Sbjct: 184 ATRWYRAPEVMLTSA-------KYSRAMDVWSCGCILAELFLRRPIFPGRDY--RHQLLL 234 Query: 235 YKIITGKPSGAISGVQKAENGPID-WSGDMPVSCS-----LSRGLQVLLTPVLANILEAD 288 I G P + + ++ E+ + +P+ + + + +L +L D Sbjct: 235 IFGIIGTP-HSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFD 293 Query: 289 QEKCW 293 K Sbjct: 294 PAKRI 298 >4AGU-A nrPDB Length = 311 Score = 201 bits (512), Expect = 7e-52, Method: Composition-based stats. Identities = 63/236 (26%), Positives = 102/236 (43%), Gaps = 21/236 (8%) Query: 7 HLWLLSDILGQGATANVFRGRHKKTGDLFAIKV-FNNISFLRPVDVQMREFEVLKKLNHK 65 + +G+G+ VF+ R++ TG + AIK + + +RE +LK+L H Sbjct: 3 EKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKHP 62 Query: 66 NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAY-GLPESEFLIVLRDVVGGMN 124 N+V L + R L+ E+C TVL E G+PE + + +N Sbjct: 63 NLVNLLEVFRR--KRRLHLVFEYCDH----TVLHELDRYQRGVPEHLVKSITWQTLQAVN 116 Query: 125 HLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELE-DDEQFVSLYGTEEYLHPD 183 ++ +HRD+KP NI+ SV KL DFG AR L + + T Y P+ Sbjct: 117 FCHKHNCIHRDVKPENILIT----KHSVIKLCDFGFARLLTGPSDYYDDEVATRWYRSPE 172 Query: 184 MYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIIT 239 + +YG VD+W+IG F +G +P P + ++ K + Sbjct: 173 LLVG-------DTQYGPPVDVWAIGCVFAELLSG-VPLWPGKSDVDQLYLIRKTLG 220 >5DYK-A nrPDB Length = 853 Score = 201 bits (512), Expect = 8e-52, Method: Composition-based stats. Identities = 67/245 (27%), Positives = 111/245 (45%), Gaps = 25/245 (10%) Query: 1 MQSTSNHLWLLS--DILGQGATANVFRGRHKKTGDLFAIKVFNNISF--LRPVDVQMREF 56 MQ T + L I+G+G V HK T +A+K + S L + E Sbjct: 531 MQDTKVEMDELETERIIGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLNQQNNIKLER 590 Query: 57 EVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVL 116 E+ + +H I++L + +++ + E G LY + + L +S+ L Sbjct: 591 EITAENDHPFIIRL--VRTFKDSKYFYFLTELVTGGELYDAIRKLG---LLSKSQAQFYL 645 Query: 117 RDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGT 176 ++ + +L E IV+RD+KP NI+ D Q KL DFG A++++ + +L GT Sbjct: 646 GSIILAIEYLHERNIVYRDLKPENILL----DKQGYVKLIDFGCAKKVQ--GRAYTLVGT 699 Query: 177 EEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYK 236 Y+ P++ K YG TVD+W++G+ Y G LPF E+ Sbjct: 700 PHYMAPEVILG--------KGYGCTVDIWALGICLYEFICGPLPF--GNDEEDQLEIFRD 749 Query: 237 IITGK 241 I+TG+ Sbjct: 750 ILTGQ 754 >5FET-A nrPDB Length = 847 Score = 201 bits (512), Expect = 8e-52, Method: Composition-based stats. Identities = 66/245 (26%), Positives = 109/245 (44%), Gaps = 25/245 (10%) Query: 1 MQSTSNHLWLLS--DILGQGATANVFRGRHKKTGDLFAIKVFNNISFLR--PVDVQMREF 56 MQ T + L I+G+G V HK T +A+K + S + + E Sbjct: 525 MQDTKVEMHELETERIIGRGTFGTVKLVHHKPTQIRYALKCVSKRSIISLNQQNNIKLER 584 Query: 57 EVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVL 116 E+ + +H I++L +++ + E G LY + + L + + L Sbjct: 585 EITAENDHPFIIRLVRTFKDSN--CFYFLTELVTGGELYDAIRKLG---LLSKPQAQFYL 639 Query: 117 RDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGT 176 ++ + +L E IV+RD+KP NI+ D Q KL DFG A++++ + +L GT Sbjct: 640 GSIILAIEYLHERNIVYRDLKPENILL----DKQGYVKLIDFGCAKKIQ--GRAYTLVGT 693 Query: 177 EEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYK 236 Y+ P++ K YG TVD+W++GV Y G LPF E+ Sbjct: 694 PHYMAPEVILG--------KGYGCTVDIWALGVCLYEFICGPLPF--GNDQEDQLEIFRD 743 Query: 237 IITGK 241 I+TG+ Sbjct: 744 ILTGQ 748 >1JPA-A nrPDB Length = 312 Score = 201 bits (512), Expect = 8e-52, Method: Composition-based stats. Identities = 56/278 (20%), Positives = 108/278 (38%), Gaps = 27/278 (9%) Query: 11 LSDILGQGATANVFRGRHKKTGDL---FAIKVFNNISFLRPVDVQMREFEVLKKLNHKNI 67 + ++G G V G K G AIK + + + E ++ + +H N+ Sbjct: 37 IEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNV 96 Query: 68 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 127 + L + ++T ++I EF GSL + L + + + + + +LR + GM +L Sbjct: 97 IHLEGVVTKSTP--VMIITEFMENGSLDSFLRQNDGQFTV--IQLVGMLRGIAAGMKYLA 152 Query: 128 ENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELED---DEQFVSLYGTE---EYLH 181 + VHRD+ NI+ + V K++DFG +R LED D + S G + + Sbjct: 153 DMNYVHRDLAARNILV----NSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTA 208 Query: 182 PDMYERAVLRKDHQKKYGATVDLWSIGVTFYH-AATGSLPFRPFEGPRRNKEVMYKIITG 240 P+ + +K+ + D+WS G+ + + G P+ + Sbjct: 209 PEAIQ--------YRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLP 260 Query: 241 KPSGAISGVQKAENGPIDWSG-DMPVSCSLSRGLQVLL 277 P S + + P + L ++ Sbjct: 261 PPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDKMI 298 >4EBW-A nrPDB Length = 304 Score = 201 bits (512), Expect = 9e-52, Method: Composition-based stats. Identities = 62/297 (20%), Positives = 116/297 (39%), Gaps = 59/297 (19%) Query: 6 NHLWLLSDILGQGATANVFRGRHKKTGDL---FAIKVFNNISFLRPVDVQMREFEVLKKL 62 L +G+G +V +G + + AIK N + + ++E +++ Sbjct: 37 RERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQF 96 Query: 63 NHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGG 122 +H +IVKL + T +IME C G L + L+ Y L + ++ + Sbjct: 97 DHPHIVKLIGVI---TENPVWIIMELCTLGELRSFLQ--VRKYSLDLASLILYAYQLSTA 151 Query: 123 MNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYG--TEEYL 180 + +L VHRDI N++ + KL DFG +R +ED + + G +++ Sbjct: 152 LAYLESKRFVHRDIAARNVLVSSND----CVKLGDFGLSRYMEDSTYYKASKGKLPIKWM 207 Query: 181 HPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVMYKIIT 239 P+ + +++ + D+W GV + G PF+ +N +V+ +I Sbjct: 208 APESI--------NFRRFTSASDVWMFGVCMWEILMHGVKPFQG----VKNNDVIGRIEN 255 Query: 240 GKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFD 296 G+ MP +C P L +++ KCW +D Sbjct: 256 GER------------------LPMPPNCP----------PTLYSLM----TKCWAYD 280 >4AU8-A nrPDB Length = 296 Score = 200 bits (510), Expect = 1e-51, Method: Composition-based stats. Identities = 64/301 (21%), Positives = 125/301 (41%), Gaps = 25/301 (8%) Query: 3 STSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPV-DVQMREFEVLKK 61 + + + + +G+G VF+ ++++T ++ A+K V +RE +LK+ Sbjct: 2 AMGSQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKE 61 Query: 62 LNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVG 121 L HKNIV+L + + + L+ EFC L + S L L ++ Sbjct: 62 LKHKNIVRLHDVLH--SDKKLTLVFEFCD-QDLKKYFD--SCNGDLDPEIVKSFLFQLLK 116 Query: 122 GMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSL-YGTEEYL 180 G+ ++HRD+KP N++ + KL DFG AR + S T Y Sbjct: 117 GLGFCHSRNVLHRDLKPQNLLI----NRNGELKLADFGLARAFGIPVRCYSAEVVTLWYR 172 Query: 181 HPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITG 240 PD+ A L Y ++D+WS G F A P P + +++++ G Sbjct: 173 PPDVLFGAKL-------YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLL-G 224 Query: 241 KPS----GAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFD 296 P+ +++ + + P+ + + + + L +L N+L+ + + + Sbjct: 225 TPTEEQWPSMTKLPDYKPYPM-YPATTSLVNVVPK-LNATGRDLLQNLLKCNPVQRISAE 282 Query: 297 Q 297 + Sbjct: 283 E 283 >2F57-A nrPDB Length = 317 Score = 200 bits (509), Expect = 2e-51, Method: Composition-based stats. Identities = 57/247 (23%), Positives = 105/247 (42%), Gaps = 26/247 (10%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 74 +G+G+T V K TG A+K + + ++ E +++ +H N+V +++ Sbjct: 53 IGEGSTGIVCIATEKHTGKQVAVKKMDLRK-QQRRELLFNEVVIMRDYHHDNVVDMYSSY 111 Query: 75 EETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHR 134 ++MEF G+L ++ + E + V V+ +++L G++HR Sbjct: 112 L--VGDELWVVMEFLEGGALTDIVTHTR----MNEEQIATVCLSVLRALSYLHNQGVIHR 165 Query: 135 DIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD-EQFVSLYGTEEYLHPDMYERAVLRKD 193 DIK +I+ KL+DFG ++ + + SL GT ++ P++ R Sbjct: 166 DIKSDSILLT----SDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRL----- 216 Query: 194 HQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGA--ISGVQK 251 YG VD+WS+G+ G P+ F P + M +I P + V Sbjct: 217 ---PYGTEVDIWSLGIMVIEMIDGEPPY--FNEPP--LQAMRRIRDSLPPRVKDLHKVSS 269 Query: 252 AENGPID 258 G +D Sbjct: 270 VLRGFLD 276 >5AWM-A nrPDB Length = 394 Score = 200 bits (509), Expect = 2e-51, Method: Composition-based stats. Identities = 67/314 (21%), Positives = 111/314 (35%), Gaps = 37/314 (11%) Query: 3 STSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVF-NNISFLRPVDVQMREFEVLKK 61 T + ++ +G GA V T AIK + REF+++K Sbjct: 40 FTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKL 99 Query: 62 LNHKNIVKLFAIEEETTT----RHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLR 117 +NHKNI+ L + L+ME +L V++ L +L Sbjct: 100 VNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDA-NLCQVIQ-----MDLDHDRMSYLLY 153 Query: 118 DVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTE 177 ++ G+ HL GI+HRD+KP NI+ K+ DFG AR T Sbjct: 154 QMLCGIKHLHSAGIIHRDLKPSNIVV----KADCTLKILDFGLARTAGTTFMMTPYVVTR 209 Query: 178 EYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKI 237 Y P++ Y VD+WS+G G + F + + +++ ++ Sbjct: 210 YYRAPEVILGM--------GYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQL 261 Query: 238 ITGKPSGA---ISGVQKAENGPIDWSGDM-----------PVSCSLSRGLQVLLTPVLAN 283 T PS V+ ++G + SR +L+ Sbjct: 262 GTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSK 321 Query: 284 ILEADQEKCWGFDQ 297 +L D E+ D+ Sbjct: 322 MLVIDPEQRISVDE 335 >4APC-A nrPDB Length = 350 Score = 200 bits (509), Expect = 2e-51, Method: Composition-based stats. Identities = 62/278 (22%), Positives = 99/278 (35%), Gaps = 28/278 (10%) Query: 1 MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFL-RPVDVQMREFEVL 59 QS ++ +G+G+ + + G + IK N + + RE VL Sbjct: 20 FQSM--EKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVL 77 Query: 60 KKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDV 119 + H NIV+ EE + ++M++C G L+ + E + L + Sbjct: 78 ANMKHPNIVQYRESFEENGS--LYIVMDYCEGGDLFKRINAQKGVL-FQEDQILDWFVQI 134 Query: 120 VGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLY-GTEE 178 + H+ + I+HRDIK NI +L DFG AR L + GT Sbjct: 135 CLALKHVHDRKILHRDIKSQNIFLT----KDGTVQLGDFGIARVLNSTVELARACIGTPY 190 Query: 179 YLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKII 238 YL P++ E K Y D+W++G Y T F K ++ KII Sbjct: 191 YLSPEICE--------NKPYNNKSDIWALGCVLYELCTLKHAFEA----GSMKNLVLKII 238 Query: 239 TGKPSGAISGVQKAENGPIDWS-----GDMPVSCSLSR 271 +G + D P S+ Sbjct: 239 SGSFPPVSLHYSYDLRSLVSQLFKRNPRDRPSVNSILE 276 >2XNP-A nrPDB Length = 279 Score = 200 bits (508), Expect = 2e-51, Method: Composition-based stats. Identities = 63/241 (26%), Positives = 99/241 (41%), Gaps = 24/241 (9%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLR-PVDVQMREFEVLKKLNHKNI 67 + + +G G+ + R K G + K + S + + E +L++L H NI Sbjct: 8 YEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNI 67 Query: 68 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEE-PSNAYGLPESEFLIVLRDVVGGMNHL 126 V+ + + T ++ME+C G L +V+ + L E L V+ + + Sbjct: 68 VRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKEC 127 Query: 127 RE-----NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQF-VSLYGTEEYL 180 + ++HRD+KP N+ DG+ KL DFG AR L D F + GT Y+ Sbjct: 128 HRRSDGGHTVLHRDLKPANVFL----DGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYM 183 Query: 181 HPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITG 240 P+ R Y D+WS+G Y PF F KE+ KI G Sbjct: 184 SPEQMNRM--------SYNEKSDIWSLGCLLYELCALMPPFTAF----SQKELAGKIREG 231 Query: 241 K 241 K Sbjct: 232 K 232 >4LG4-A nrPDB Length = 299 Score = 200 bits (508), Expect = 2e-51, Method: Composition-based stats. Identities = 64/284 (22%), Positives = 120/284 (42%), Gaps = 32/284 (11%) Query: 5 SNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNH 64 ++ + + LG+G+ +VF+ HK++G + AIK S L+ + ++E ++++ + Sbjct: 9 PEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEI---IKEISIMQQCDS 65 Query: 65 KNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 124 +VK + + T ++ME+C GS+ ++ L E E +L+ + G+ Sbjct: 66 PYVVKYYGSYFKNTD--LWIVMEYCGAGSVSDIIR--LRNKTLIEDEIATILKSTLKGLE 121 Query: 125 HLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD-EQFVSLYGTEEYLHPD 183 +L +HR+IK GNI+ + + KL DFG A +L D + ++ GT ++ P+ Sbjct: 122 YLHFMRKIHRNIKAGNILL----NTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPE 177 Query: 184 MYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS 243 + + Y D+WS+G+T A G P+ R ++ I T P Sbjct: 178 VIQEI--------GYNCVADIWSLGITSIEMAEGKPPYADIHPMRA----IFMIPTNPPP 225 Query: 244 GAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEA 287 P WS D +L+ Sbjct: 226 TF--------RKPELWSDDFTDFVKKCLVKNPEQRATATQLLQH 261 >4YFF-A nrPDB Length = 311 Score = 200 bits (508), Expect = 2e-51, Method: Composition-based stats. Identities = 65/271 (23%), Positives = 117/271 (43%), Gaps = 37/271 (13%) Query: 10 LLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISF--LRPVDVQMREFEVLKKLNHKNI 67 +I+G G+ V++GR + + AIK + ++ VD+ RE +L +LNH + Sbjct: 45 EFHEIIGSGSFGKVYKGRCRN--KIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCV 102 Query: 68 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 127 ++ ++ ++ ++ GSL+++L E L LI+ DV GM +L Sbjct: 103 IQFVGACLNDPSQF-AIVTQYISGGSLFSLLHEQKRI--LDLQSKLIIAVDVAKGMEYLH 159 Query: 128 E--NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELE--DDEQFVSLYGTEEYLHPD 183 I+HRD+ NI+ EDG +V DFG +R L+ D++ G ++ P+ Sbjct: 160 NLTQPIIHRDLNSHNILLY--EDGHAVV--ADFGESRFLQSLDEDNMTKQPGNLRWMAPE 215 Query: 184 MYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS 243 ++ + +Y D++S + + TG +PF + ++ Y I Sbjct: 216 VFTQCT-------RYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHI----- 263 Query: 244 GAISGVQKAENGPIDWSGDMPVSCSLSRGLQ 274 PI +S P+S L RG Sbjct: 264 ----------RPPIGYSIPKPISSLLIRGWN 284 >5NGU-A nrPDB Length = 381 Score = 199 bits (507), Expect = 3e-51, Method: Composition-based stats. Identities = 55/299 (18%), Positives = 103/299 (34%), Gaps = 33/299 (11%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 74 +G+GA V AIK + +RE ++L + H+NI+ + I Sbjct: 50 IGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDII 109 Query: 75 EETT---TRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGI 131 T + ++ + LY +L+ L L ++ G+ ++ + Sbjct: 110 RAPTIEQMKDVYIVQDLME-TDLYKLLK----TQHLSNDHICYFLYQILRGLKYIHSANV 164 Query: 132 VHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSL----YGTEEYLHPDMYER 187 +HRD+KP N++ D K+ DFG AR + D T Y P++ Sbjct: 165 LHRDLKPSNLLLNTTCD----LKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIM-- 218 Query: 188 AVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAIS 247 + K Y ++D+WS+G + F + + + I+ S + Sbjct: 219 -----LNSKGYTKSIDIWSVGCILAEMLSNRPIFPG----KHYLDQLNHILGILGSPSQE 269 Query: 248 GVQKAENGPID-WSGDMP-----VSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFA 300 + N + +P L +L +L + K +Q A Sbjct: 270 DLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALA 328 >3QGY-A nrPDB Length = 286 Score = 199 bits (507), Expect = 3e-51, Method: Composition-based stats. Identities = 73/281 (25%), Positives = 113/281 (40%), Gaps = 33/281 (11%) Query: 10 LLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVK 69 +G G V G AIK S D + E EV+ KL+H +V+ Sbjct: 30 TFVQEIGSGQFGLVHLGYWLNKDK-VAIKTIKEGSMSE--DDFIEEAEVMMKLSHPKLVQ 86 Query: 70 LFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN 129 L+ + E L+ EF G L L + L + DV GM +L E Sbjct: 87 LYGVCLEQAP--ICLVFEFMEHGCLSDYLRTQRGLFAA--ETLLGMCLDVCEGMAYLEEA 142 Query: 130 GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTE---EYLHPDMYE 186 ++HRD+ N + + V K++DFG R + DD+ + S GT+ ++ P+++ Sbjct: 143 CVIHRDLAARNCLVGENQ----VIKVSDFGMTRFVLDDQ-YTSSTGTKFPVKWASPEVFS 197 Query: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVMYKIITG----K 241 +Y + D+WS GV + + G +P+ R N EV+ I TG K Sbjct: 198 --------FSRYSSKSDVWSFGVLMWEVFSEGKIPYE----NRSNSEVVEDISTGFRLYK 245 Query: 242 PSGAISGV-QKAENGPIDWSGDMPVSCSLSRGLQVLLTPVL 281 P A + V Q + + D P L R L + L Sbjct: 246 PRLASTHVYQIMNHCWKERPEDRPAFSRLLRQLAEIAESGL 286 >6FYV-A nrPDB Length = 337 Score = 199 bits (507), Expect = 3e-51, Method: Composition-based stats. Identities = 68/330 (20%), Positives = 118/330 (35%), Gaps = 55/330 (16%) Query: 6 NHLWLLSDILGQGATANVFRGRHKK-TGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNH 64 + + D LG+GA V G A+K+ N+ R + E +VL+ LN Sbjct: 13 RARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNV--GRYREAARSEIQVLEHLNS 70 Query: 65 --KN----IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRD 118 N V++ + H ++ E S Y ++E S + Sbjct: 71 TDPNSVFRCVQMLEWFD--HHGHVCIVFELL-GLSTYDFIKENS-FLPFQIDHIRQMAYQ 126 Query: 119 VVGGMNHLRENGIVHRDIKPGNIMRV-----------IGEDGQSV----YKLTDFGAARE 163 + +N L N + H D+KP NI+ V + D +++ K+ DFG+A Sbjct: 127 ICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSAT- 185 Query: 164 LEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRP 223 DDE +L T Y P++ + D+WSIG G F+ Sbjct: 186 -YDDEHHSTLVSTRHYRAPEVILAL--------GWSQPCDVWSIGCILIEYYLGFTVFQT 236 Query: 224 FEGPRRNKEVMYKIITGKPSGAISGVQKAE---NGPIDWSGDMPVSCSLSRGLQVLLTPV 280 + + + +M +I+ P I +K + + +DW + R + L + Sbjct: 237 HDS-KEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFM 295 Query: 281 L-------------ANILEADQEKCWGFDQ 297 L +LE D + D+ Sbjct: 296 LCHDEEHEKLFDLVRRMLEYDPTQRITLDE 325 >3V5Q-A nrPDB Length = 297 Score = 199 bits (506), Expect = 4e-51, Method: Composition-based stats. Identities = 59/263 (22%), Positives = 98/263 (37%), Gaps = 41/263 (15%) Query: 1 MQSTSNHLWLLSDILGQGATANVFRGRH-----KKTGDLFAIKVFNNISFLRPVDVQMRE 55 +Q +L LG+GA VF K L A+K + + D Q RE Sbjct: 9 VQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQ-RE 67 Query: 56 FEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSN------------ 103 E+L L H++IVK + + + +++ E+ G L L Sbjct: 68 AELLTNLQHEHIVKFYGVCGDGDP--LIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQ 125 Query: 104 -AYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAAR 162 L S+ L + + GM +L VHRD+ N + + K+ DFG +R Sbjct: 126 AKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVG----ANLLVKIGDFGMSR 181 Query: 163 ELEDDEQFVSLYGT---EEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GS 218 ++ + + T ++ P+ +K+ D+WS GV + T G Sbjct: 182 DVYSTDYYRVGGHTMLPIRWMPPESIM--------YRKFTTESDVWSFGVILWEIFTYGK 233 Query: 219 LPFRPFEGPRRNKEVMYKIITGK 241 P+ N EV+ I G+ Sbjct: 234 QPWFQL----SNTEVIECITQGR 252 >3DKO-A nrPDB Length = 318 Score = 199 bits (506), Expect = 4e-51, Method: Composition-based stats. Identities = 55/252 (21%), Positives = 106/252 (42%), Gaps = 28/252 (11%) Query: 11 LSDILGQGATANVFRGRHKKTGDL---FAIKVFNNISFLRPVDVQMREFEVLKKLNHKNI 67 + ++G G V GR K G AIK + + E ++ + +H N+ Sbjct: 47 IERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNV 106 Query: 68 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 127 V L + + ++++EF G+L L + + + + + +LR + GM +L Sbjct: 107 VHLEGVVTRG--KPVMIVIEFMENGALDAFLRKHDGQFTV--IQLVGMLRGIAAGMRYLA 162 Query: 128 ENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQ--FVSLYG--TEEYLHPD 183 + G VHRD+ NI+ + V K++DFG +R +EDD + + + G + P+ Sbjct: 163 DMGYVHRDLAARNILV----NSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPE 218 Query: 184 MYERAVLRKDHQKKYGATVDLWSIGVTFYH-AATGSLPFRPFEGPRRNKEVMYKIITGKP 242 + +K+ + D+WS G+ + + G P+ N++V+ I G Sbjct: 219 AIQ--------YRKFTSASDVWSYGIVMWEVMSYGERPYW----DMSNQDVIKAIEEGYR 266 Query: 243 SGAISGVQKAEN 254 A + Sbjct: 267 LPAPMDCPAGLH 278 >5VO2-A nrPDB Length = 300 Score = 199 bits (505), Expect = 4e-51, Method: Composition-based stats. Identities = 67/278 (24%), Positives = 114/278 (41%), Gaps = 44/278 (15%) Query: 5 SNHLWL--LSDIL-----GQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFE 57 S LW +IL G GA VF GR G+ A+K ++ + Sbjct: 3 SEDLWEVPFEEILDLQWVGSGAQGAVFLGRFH--GEEVAVKKVRDLKETD--------IK 52 Query: 58 VLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLR 117 L+KL H NI+ + + ++MEFC G LY VL + S + Sbjct: 53 HLRKLKHPNIITFKGVCTQAPCY--CILMEFCAQGQLYEVLRAGR---PVTPSLLVDWSM 107 Query: 118 DVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTE 177 + GGMN+L + I+HRD+K N++ + V K++DFG ++EL D +S GT Sbjct: 108 GIAGGMNYLHLHKIIHRDLKSPNMLITYDD----VVKISDFGTSKELSDKSTKMSFAGTV 163 Query: 178 EYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKI 237 ++ P++ + VD+WS GV + TG +P++ + +++ + Sbjct: 164 AWMAPEVIRNEPV--------SEKVDIWSFGVVLWELLTGEIPYKDVDS----SAIIWGV 211 Query: 238 IT-----GKPSGAISGVQKAENGPIDWSG-DMPVSCSL 269 + PS G + + + P + Sbjct: 212 GSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQI 249 >3Q53-A nrPDB Length = 306 Score = 199 bits (505), Expect = 5e-51, Method: Composition-based stats. Identities = 54/220 (24%), Positives = 96/220 (43%), Gaps = 20/220 (9%) Query: 3 STSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKL 62 + + +GQGA+ V+ TG AI+ N + ++ + E V+++ Sbjct: 17 GDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIRQMNLQQQPKK-ELIINEILVMREN 75 Query: 63 NHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGG 122 + NIV ++ME+ GSL V+ E + E + V R+ + Sbjct: 76 KNPNIVNYLDSYL--VGDELWVVMEYLAGGSLTDVVTETC----MDEGQIAAVCRECLQA 129 Query: 123 MNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDE-QFVSLYGTEEYLH 181 + L N ++HRDIK NI+ + KLTDFG ++ ++ + ++ GT ++ Sbjct: 130 LEFLHSNQVIHRDIKSDNILLGMD----GSVKLTDFGFCAQITPEQSKRSTMVGTPYWMA 185 Query: 182 PDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 P++ R K YG VD+WS+G+ G P+ Sbjct: 186 PEVVTR--------KAYGPKVDIWSLGIMAIEMIEGEPPY 217 >3A8W-A nrPDB Length = 345 Score = 198 bits (504), Expect = 6e-51, Method: Composition-based stats. Identities = 60/231 (25%), Positives = 103/231 (44%), Gaps = 24/231 (10%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDV--QMREFEVLKKL-NHK 65 + L ++G+G+ A V R KKT ++A+KV D+ E V ++ NH Sbjct: 11 FDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHP 70 Query: 66 NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 125 +V L + + T ++E+ G L ++ LPE ++ +N+ Sbjct: 71 FLVGLHSCFQ--TESRLFFVIEYVNGGDLMFHMQRQRK---LPEEHARFYSAEISLALNY 125 Query: 126 LRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARE-LEDDEQFVSLYGTEEYLHPDM 184 L E GI++RD+K N++ D + KLTD+G +E L + + GT Y+ P++ Sbjct: 126 LHERGIIYRDLKLDNVLL----DSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEI 181 Query: 185 YERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFR---PFEGPRRNKE 232 + YG +VD W++GV + G PF + P +N E Sbjct: 182 LRG--------EDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTE 224 >3D2K-A nrPDB Length = 272 Score = 198 bits (504), Expect = 6e-51, Method: Composition-based stats. Identities = 64/277 (23%), Positives = 118/277 (42%), Gaps = 38/277 (13%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRP-VDVQMR-EFEVLKKLNHKN 66 + + LG+G NV+ R +++ + A+KV + V+ Q+R E E+ L H N Sbjct: 14 FDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVEHQLRREVEIQSHLRHPN 73 Query: 67 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 126 I++L+ + T LI+E+ P G++Y L++ S E + ++ +++ Sbjct: 74 ILRLYGYFHDATR--VYLILEYAPLGTVYRELQKLSR---FDEQRTATYITELANALSYC 128 Query: 127 RENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYE 186 ++HRDIKP N++ K+ DFG + + +L GT +YL P+M E Sbjct: 129 HSKRVIHRDIKPENLLLG----SNGELKIADFGWSVH-APSSRRTTLCGTLDYLPPEMIE 183 Query: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF------------------RPFEGPR 228 + + VDLWS+GV Y G PF P Sbjct: 184 G--------RMHDEKVDLWSLGVLCYEFLVGMPPFEAHTYQETYRRISRVEFTFPDFVTE 235 Query: 229 RNKEVMYKIITGKPSGAISGVQKAENGPIDWSGDMPV 265 ++++ +++ S ++ + E+ I + P Sbjct: 236 GARDLISRLLKHNASQRLTLAEVLEHPWIKANSSKPS 272 >2VWV-A nrPDB Length = 302 Score = 198 bits (503), Expect = 8e-51, Method: Composition-based stats. Identities = 58/282 (20%), Positives = 105/282 (37%), Gaps = 27/282 (9%) Query: 7 HLWLLSDILGQGATANVFRGRHKKTGDL---FAIKVFNNISFLRPVDVQMREFEVLKKLN 63 + +++G G V RGR K G AIK R + E ++ + Sbjct: 16 SYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSEASIMGQFE 75 Query: 64 HKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 123 H NI++L + T + +++ EF G+L + L N + + +LR + GM Sbjct: 76 HPNIIRLEGVV--TNSMPVMILTEFMENGALDSFLR--LNDGQFTVIQLVGMLRGIASGM 131 Query: 124 NHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELED---DEQFVSLYGTE--- 177 +L E VHRD+ NI+ + V K++DFG +R LE+ D S G + Sbjct: 132 RYLAEMSYVHRDLAARNILV----NSNLVCKVSDFGLSRFLEENSSDPTETSSLGGKIPI 187 Query: 178 EYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVMYK 236 + P+ +K+ + D WS G+ + + G P+ + Sbjct: 188 RWTAPEAIA--------FRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQD 239 Query: 237 IITGKPSGAISGVQKAENGPIDWSGD-MPVSCSLSRGLQVLL 277 P + + + + P + L ++ Sbjct: 240 YRLPPPPDCPTSLHQLMLDCWQKDRNARPRFPQVVSALDKMI 281 >6AO5-A nrPDB Length = 362 Score = 198 bits (503), Expect = 9e-51, Method: Composition-based stats. Identities = 64/284 (22%), Positives = 120/284 (42%), Gaps = 32/284 (11%) Query: 5 SNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNH 64 ++ + + LG+G+ +VF+ HK++G + AIK S L+ + ++E ++++ + Sbjct: 8 PEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEI---IKEISIMQQCDS 64 Query: 65 KNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 124 +VK + + T ++ME+C GS+ ++ L E E +L+ + G+ Sbjct: 65 PYVVKYYGSYFKNTD--LWIVMEYCGAGSVSDIIR--LRNKTLIEDEIATILKSTLKGLE 120 Query: 125 HLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD-EQFVSLYGTEEYLHPD 183 +L +HR+IK GNI+ + + KL DFG A +L D + ++ GT ++ P+ Sbjct: 121 YLHFMRKIHRNIKAGNILL----NTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPE 176 Query: 184 MYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS 243 + + Y D+WS+G+T A G P+ R ++ I T P Sbjct: 177 VIQEI--------GYNCVADIWSLGITSIEMAEGKPPYADIHPMRA----IFMIPTNPPP 224 Query: 244 GAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEA 287 P WS D +L+ Sbjct: 225 TF--------RKPELWSDDFTDFVKKCLVKNPEQRATATQLLQH 260 >2J0K-A nrPDB Length = 656 Score = 198 bits (503), Expect = 9e-51, Method: Composition-based stats. Identities = 61/297 (20%), Positives = 115/297 (38%), Gaps = 59/297 (19%) Query: 6 NHLWLLSDILGQGATANVFRGRHK---KTGDLFAIKVFNNISFLRPVDVQMREFEVLKKL 62 L +G+G +V +G + AIK N + + ++E +++ Sbjct: 389 RERIELGRCIGEGQFGDVHQGIYMSPENPAMAVAIKTCKNCTSDSVREKFLQEALTMRQF 448 Query: 63 NHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGG 122 +H +IVKL + T +IME C G L + L+ + L + ++ + Sbjct: 449 DHPHIVKLIGVI---TENPVWIIMELCTLGELRSFLQ--VRKFSLDLASLILYAYQLSTA 503 Query: 123 MNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYG--TEEYL 180 + +L VHRDI N++ + KL DFG +R +ED + + G +++ Sbjct: 504 LAYLESKRFVHRDIAARNVLVSATD----CVKLGDFGLSRYMEDSTYYKASKGKLPIKWM 559 Query: 181 HPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVMYKIIT 239 P+ + +++ + D+W GV + G PF+ +N +V+ +I Sbjct: 560 APESI--------NFRRFTSASDVWMFGVCMWEILMHGVKPFQG----VKNNDVIGRIEN 607 Query: 240 GKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFD 296 G+ MP +C P L +++ KCW +D Sbjct: 608 GER------------------LPMPPNCP----------PTLYSLM----TKCWAYD 632 >2OGV-A nrPDB Length = 317 Score = 197 bits (502), Expect = 1e-50, Method: Composition-based stats. Identities = 59/293 (20%), Positives = 99/293 (33%), Gaps = 37/293 (12%) Query: 4 TSNHLWLLSDILGQGATANVFRGRHKKTGDL-----FAIKVFNNISFLRPVDVQMREFEV 58 + LG GA V G A+K+ + + + M E ++ Sbjct: 35 FPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKI 94 Query: 59 LKKL-NHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEP-------SNAYGLPES 110 + L H+NIV L T ++I E+C G L L + L Sbjct: 95 MSHLGQHENIVNLLGAC--THGGPVLVITEYCCYGDLLNFLRRKAEADLDKEDGRPLELR 152 Query: 111 EFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQF 170 + L V GM L +HRD+ N++ G V K+ DFG AR++ +D + Sbjct: 153 DLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGH----VAKIGDFGLARDIMNDSNY 208 Query: 171 VSLYGTE---EYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGP 227 + +++ P+ V Y D+WS G+ + + L P+ G Sbjct: 209 IVKGNARLPVKWMAPESIFDCV--------YTVQSDVWSYGILLWEIFS--LGLNPYPGI 258 Query: 228 RRNKEVMYKIITG----KPSGAISGVQKAENGPIDWSG-DMPVSCSLSRGLQV 275 N + + G +P+ A + P + LQ Sbjct: 259 LVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQE 311 >5YV8-A nrPDB Length = 298 Score = 197 bits (502), Expect = 1e-50, Method: Composition-based stats. Identities = 60/241 (24%), Positives = 104/241 (43%), Gaps = 39/241 (16%) Query: 7 HLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLR------------------- 47 + + L D +G+G+ V ++ +A+KV + +R Sbjct: 13 NQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGG 72 Query: 48 ------PVDVQMREFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEP 101 P++ +E +LKKL+H N+VKL + ++ H ++ E G + V Sbjct: 73 CIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEV---- 128 Query: 102 SNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAA 161 L E + +D++ G+ +L I+HRDIKP N++ +GEDG K+ DFG + Sbjct: 129 PTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLL--VGEDG--HIKIADFGVS 184 Query: 162 RELE-DDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLP 220 E + D + GT ++ P+ G +D+W++GVT Y G P Sbjct: 185 NEFKGSDALLSNTVGTPAFMAPESLSETRKIFS-----GKALDVWAMGVTLYCFVFGQCP 239 Query: 221 F 221 F Sbjct: 240 F 240 >1V0B-A nrPDB Length = 288 Score = 197 bits (501), Expect = 1e-50, Method: Composition-based stats. Identities = 67/291 (23%), Positives = 122/291 (41%), Gaps = 27/291 (9%) Query: 13 DILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPV-DVQMREFEVLKKLNHKNIVKLF 71 + +G+G V++ ++ G+ FA+K + +RE +LK+L H NIVKL+ Sbjct: 8 EKIGEGTYGVVYKAQNNY-GETFALKKIRLEKEDEGIPSTTIREISILKELKHSNIVKLY 66 Query: 72 AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGI 131 + T + VL+ E L +L+ GL L ++ G+ + + + Sbjct: 67 DVIH--TKKRLVLVFEHLD-QDLKKLLD--VCEGGLESVTAKSFLLQLLNGIAYCHDRRV 121 Query: 132 VHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELE-DDEQFVSLYGTEEYLHPDMYERAVL 190 +HRD+KP N++ + + K+ DFG AR ++ T Y PD+ + Sbjct: 122 LHRDLKPQNLLI----NREGELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVLMGS-- 175 Query: 191 RKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS----GAI 246 KKY T+D+WS+G F G+ F + + I G P+ + Sbjct: 176 -----KKYSTTIDIWSVGCIFAEMVNGAPLFPGVSEADQLMRIFR--ILGTPNSKNWPNV 228 Query: 247 SGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQ 297 + + K + + +P L +GL +L+ +L+ D + Q Sbjct: 229 TELPKYDPNFTVY-EPLPWESFL-KGLDESGIDLLSKMLKLDPNQRITAKQ 277 >1KOB-A nrPDB Length = 387 Score = 197 bits (501), Expect = 1e-50, Method: Composition-based stats. Identities = 66/232 (28%), Positives = 101/232 (43%), Gaps = 15/232 (6%) Query: 2 QSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKK 61 Q + + + + LG GA V R K TG +F K N L E ++ + Sbjct: 46 QGSVYDYYDILEELGSGAFGVVHRCVEKATGRVFVAKFINTPYPLDKY-TVKNEISIMNQ 104 Query: 62 LNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVG 121 L+H ++ L E+ VLI+EF G L+ + Y + E+E + +R Sbjct: 105 LHHPKLINLHDAFED--KYEMVLILEFLSGGELFDRIAAED--YKMSEAEVINYMRQACE 160 Query: 122 GMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLH 181 G+ H+ E+ IVH DIKP NIM + K+ DFG A +L DE T E+ Sbjct: 161 GLKHMHEHSIVHLDIKPENIMCETKKASS--VKIIDFGLATKLNPDEIVKVTTATAEFAA 218 Query: 182 PDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEV 233 P++ +R + G D+W+IGV Y +G PF + + V Sbjct: 219 PEIVDREPV--------GFYTDMWAIGVLGYVLLSGLSPFAGEDDLETLQNV 262 >4I6B-A nrPDB Length = 308 Score = 197 bits (500), Expect = 2e-50, Method: Composition-based stats. Identities = 64/275 (23%), Positives = 118/275 (42%), Gaps = 28/275 (10%) Query: 4 TSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQM--REFEVLKK 61 T+ + LG+G A + ++A K+ + +P + +E E+ + Sbjct: 25 TTGKRYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDKEIELHRI 84 Query: 62 LNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVG 121 L+HK++V+ + E+ + +++E+C S+ +L+ L E E LR +V Sbjct: 85 LHHKHVVQFYHYFED--KENIYILLEYCSRRSMAHILKARK---VLTEPEVRYYLRQIVS 139 Query: 122 GMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELED-DEQFVSLYGTEEYL 180 G+ +L E I+HRD+K GN + K+ DFG A LE + + ++ GT YL Sbjct: 140 GLKYLHEQEILHRDLKLGNFFI----NESMELKVGDFGLAARLEPLEHRRRTICGTPNYL 195 Query: 181 HPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITG 240 P++ +++ +GA D+W++G Y G PF KE I Sbjct: 196 SPEVL--------NKQGHGAESDIWALGCVMYTMLLGRPPFETT----NLKETYRSIREA 243 Query: 241 K---PSGAISGVQKAENGPIDWSG-DMPVSCSLSR 271 + PS ++ + + + D P + R Sbjct: 244 RYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIR 278 >6GQK-A nrPDB Length = 328 Score = 197 bits (500), Expect = 2e-50, Method: Composition-based stats. Identities = 60/297 (20%), Positives = 103/297 (34%), Gaps = 39/297 (13%) Query: 4 TSNHLWLLSDILGQGATANVFRG-----RHKKTGDLFAIKVFNNISFLRPVDVQMREFEV 58 + LG GA V A+K+ + + M E +V Sbjct: 38 FPRNRLSFGKTLGAGAFGKVVEATAQGLIKSDAAMTVAVKMLKPSAHSTEREALMSELKV 97 Query: 59 LKKL-NHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAY------------ 105 L L NH+NIV L T ++I E+C G L L + + Sbjct: 98 LSYLGNHENIVNLLGAC--THGGPTLVITEYCCYGDLLNFLRRKRDEFVPYKVAPEDLYK 155 Query: 106 -GLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAAREL 164 L L V GM L +HRD+ NI+ G + K+ DFG AR++ Sbjct: 156 DFLTLEHLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGN----ITKICDFGLARDI 211 Query: 165 EDDEQFVSLYGTE---EYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLP 220 ++D +V +++ P+ +V Y D+WS G+ + + GS P Sbjct: 212 KNDSNYVDKGNARLPVKWMAPESIFNSV--------YTFESDVWSYGIFLWELFSLGSSP 263 Query: 221 FRPFEGPRRNKEVMYK-IITGKPSGAISGVQKAENGPIDWSGD-MPVSCSLSRGLQV 275 + + +++ + P A + + D D P + + ++ Sbjct: 264 YPGMPVDSKFYKMIKEGFRMSSPEYAPAEMYDIMKTCWDADPDKRPTFKQIVQDIEK 320 >4U41-A nrPDB Length = 332 Score = 197 bits (500), Expect = 2e-50, Method: Composition-based stats. Identities = 61/224 (27%), Positives = 101/224 (45%), Gaps = 16/224 (7%) Query: 3 STSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKL 62 ++ L +++G G V++GRH KTG L AIKV + E +LKK Sbjct: 20 RDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKL--EINMLKKY 77 Query: 63 -NHKNIVKLFAIE----EETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLR 117 +H+NI + L+MEFC GS+ L + + L E + R Sbjct: 78 SHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITD-LVKNTKGNTLKEDWIAYISR 136 Query: 118 DVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD-EQFVSLYGT 176 +++ G+ HL + ++HRDIK N++ + KL DFG + +L+ + + GT Sbjct: 137 EILRGLAHLHIHHVIHRDIKGQNVLLTENAE----VKLVDFGVSAQLDRTVGRRNTFIGT 192 Query: 177 EEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLP 220 ++ P++ ++ Y DLWS G+T A G+ P Sbjct: 193 PYWMAPEVI---ACDENPDATYDYRSDLWSCGITAIEMAEGAPP 233 >2H8H-A nrPDB Length = 535 Score = 196 bits (499), Expect = 2e-50, Method: Composition-based stats. Identities = 63/286 (22%), Positives = 113/286 (39%), Gaps = 33/286 (11%) Query: 4 TSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLN 63 L LGQG V+ G T AIK + + ++E +V+KKL Sbjct: 264 IPRESLRLEVKLGQGCFGEVWMGTWNGT-TRVAIKTLKPGTM--SPEAFLQEAQVMKKLR 320 Query: 64 HKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 123 H+ +V+L+A+ E ++ E+ GSL L+ + Y L + + + + GM Sbjct: 321 HEKLVQLYAVVSEE---PIYIVTEYMSKGSLLDFLKGETGKY-LRLPQLVDMAAQIASGM 376 Query: 124 NHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTE---EYL 180 ++ VHRD++ NI+ V K+ DFG AR +ED+E + + G + ++ Sbjct: 377 AYVERMNYVHRDLRAANILVG----ENLVCKVADFGLARLIEDNE-YTARQGAKFPIKWT 431 Query: 181 HPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVMYKIIT 239 P+ ++ D+WS G+ T G +P+ N+EV+ ++ Sbjct: 432 APE--------AALYGRFTIKSDVWSFGILLTELTTKGRVPYPG----MVNREVLDQVER 479 Query: 240 GKPSGAISGVQKAEN-----GPIDWSGDMPVSCSLSRGLQVLLTPV 280 G ++ + + P L L+ T Sbjct: 480 GYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTST 525 >6CQF-A nrPDB Length = 297 Score = 196 bits (499), Expect = 2e-50, Method: Composition-based stats. Identities = 58/223 (26%), Positives = 94/223 (42%), Gaps = 16/223 (7%) Query: 1 MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLK 60 + L LG G VF+ R K +GDL A+K+ V +E +LK Sbjct: 10 FNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPD-DDVSTLQKEILILK 68 Query: 61 KLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVV 120 H NIV + + MEFC GSL + + + L E + V R+V+ Sbjct: 69 TCRHANIVAYHGSYL--WLQKLWICMEFCGAGSLQDIYQVTGS---LSELQISYVCREVL 123 Query: 121 GGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD-EQFVSLYGTEEY 179 G+ +L +HRDIK NI+ + +L DFG + ++ + ++ GT + Sbjct: 124 QGLAYLHSQKKIHRDIKGANILI----NDAGEVRLADFGISAQIGATLARRLAFIGTPYW 179 Query: 180 LHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFR 222 + P++ A+ + Y D+WS+G+T A P Sbjct: 180 MAPEVAAVAL-----KGGYNELCDIWSLGITAIELAELQPPLF 217 >3BEA-A nrPDB Length = 333 Score = 196 bits (499), Expect = 3e-50, Method: Composition-based stats. Identities = 60/297 (20%), Positives = 99/297 (33%), Gaps = 41/297 (13%) Query: 4 TSNHLWLLSDILGQGATANVFRGRHKKTGDL-----FAIKVFNNISFLRPVDVQMREFEV 58 + LG GA V G A+K+ + + + M E ++ Sbjct: 43 FPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKI 102 Query: 59 LKKL-NHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAY-----------G 106 + L H+NIV L T ++I E+C G L L S Sbjct: 103 MSHLGQHENIVNLLGAC--THGGPVLVITEYCCYGDLLNFLRRKSRVLETDPAFAIANST 160 Query: 107 LPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELED 166 L + L V GM L +HRD+ N++ G V K+ DFG AR++ + Sbjct: 161 LSTRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGH----VAKIGDFGLARDIMN 216 Query: 167 DEQFVSLYGTE---EYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRP 223 D ++ +++ P+ V Y D+WS G+ + + L P Sbjct: 217 DSNYIVKGNARLPVKWMAPESIFDCV--------YTVQSDVWSYGILLWEIFS--LGLNP 266 Query: 224 FEGPRRNKEVMYKIITG----KPSGAISGVQKAENGPIDWSG-DMPVSCSLSRGLQV 275 + G N + + G +P+ A + P + LQ Sbjct: 267 YPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQE 323 >3KUL-B nrPDB Length = 325 Score = 196 bits (498), Expect = 3e-50, Method: Composition-based stats. Identities = 63/278 (22%), Positives = 106/278 (38%), Gaps = 25/278 (8%) Query: 11 LSDILGQGATANVFRGRHKKTGDL---FAIKVFNNISFLRPVDVQMREFEVLKKLNHKNI 67 + I+G G + V GR + G AIK R + E ++ + +H NI Sbjct: 53 IEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGYTERQRRDFLSEASIMGQFDHPNI 112 Query: 68 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 127 ++L + R +++ E+ GSL T L + + + + +LR V GM +L Sbjct: 113 IRLEGVVTRG--RLAMIVTEYMENGSLDTFLRTHDGQFTIM--QLVGMLRGVGAGMRYLS 168 Query: 128 ENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQ--FVSLYG--TEEYLHPD 183 + G VHRD+ N++ D V K++DFG +R LEDD + + G + P+ Sbjct: 169 DLGYVHRDLAARNVLV----DSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTAPE 224 Query: 184 MYERAVLRKDHQKKYGATVDLWSIGVTFYH-AATGSLPFRPFEGPRRNKEVMYKIITGKP 242 + + + D+WS GV + A G P+ V P Sbjct: 225 AIA--------FRTFSSASDVWSFGVVMWEVLAYGERPYWNMTNRDVISSVEEGYRLPAP 276 Query: 243 SGAISGV-QKAENGPIDWSGDMPVSCSLSRGLQVLLTP 279 G + Q + P + L L+ Sbjct: 277 MGCPHALHQLMLDCWHKDRAQRPRFSQIVSVLDALIRS 314 >4MYG-A nrPDB Length = 372 Score = 196 bits (498), Expect = 3e-50, Method: Composition-based stats. Identities = 69/306 (22%), Positives = 115/306 (37%), Gaps = 36/306 (11%) Query: 2 QSTSNHLWLLSDI------LGQGATANVFRGRHKKTGDLFAIKVF-NNISFLRPVDVQMR 54 Q + W L +G GA +V K++G+ AIK R Sbjct: 32 QDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYR 91 Query: 55 EFEVLKKLNHKNIVKLFAIEEETTTR----HKVLIMEFCPCGSLYTVLEEPSNAYGLPES 110 E +LK + H+N++ L + ++ L+M F L ++ E Sbjct: 92 ELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQ-TDLQKIM-----GMEFSEE 145 Query: 111 EFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQF 170 + ++ ++ G+ ++ G+VHRD+KPGN + ED + K+ DFG AR D + Sbjct: 146 KIQYLVYQMLKGLKYIHSAGVVHRDLKPGN--LAVNEDCE--LKILDFGLAR--HADAEM 199 Query: 171 VSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRN 230 T Y P++ + Y TVD+WS+G TG F+ + + Sbjct: 200 TGYVVTRWYRAPEVILSWM-------HYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQL 252 Query: 231 KEVMYKIITGKPSGAISGV--QKAENGPIDWSGDMPV--SCSLSRGLQVLLTPVLANILE 286 +++ +TG P KA I P L +L +LE Sbjct: 253 TQILK--VTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLE 310 Query: 287 ADQEKC 292 D +K Sbjct: 311 LDVDKR 316 >4TNB-A nrPDB Length = 590 Score = 196 bits (498), Expect = 3e-50, Method: Composition-based stats. Identities = 52/240 (21%), Positives = 101/240 (42%), Gaps = 17/240 (7%) Query: 2 QSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPV--DVQMREFEVL 59 Q + + + +LG+G V + + TG ++A K + + + E ++L Sbjct: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQIL 238 Query: 60 KKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDV 119 +K+N + +V L T L++ G L + N G E L ++ Sbjct: 239 EKVNSQFVVNL--AYAYETKDALCLVLTIMNGGDLKFHIYNMGNP-GFEEERALFYAAEI 295 Query: 120 VGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEY 179 + G+ L V+RD+KP NI+ D +++D G A ++ + + GT Y Sbjct: 296 LCGLEDLHHENTVYRDLKPENILL----DDYGHIRISDLGLAVKIPEGDLIRGRVGTVGY 351 Query: 180 LHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIIT 239 + P++ + ++YG + D W +G Y G PFR + + +EV +++ Sbjct: 352 MAPEVL--------NNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLE 403 >4QTB-A nrPDB Length = 380 Score = 196 bits (498), Expect = 4e-50, Method: Composition-based stats. Identities = 53/311 (17%), Positives = 106/311 (34%), Gaps = 33/311 (10%) Query: 3 STSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKL 62 + +G+GA V AIK + +RE ++L + Sbjct: 37 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRF 96 Query: 63 NHKNIVKLFAIEEETT---TRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDV 119 H+N++ + I +T R ++ + LY +L+ + L L + Sbjct: 97 RHENVIGIRDILRASTLEAMRDVYIVQDLME-TDLYKLLK----SQQLSNDHICYFLYQI 151 Query: 120 VGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSL----YG 175 + G+ ++ ++HRD+KP N++ D K+ DFG AR + + Sbjct: 152 LRGLKYIHSANVLHRDLKPSNLLINTTCD----LKICDFGLARIADPEHDHTGFLTEYVA 207 Query: 176 TEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMY 235 T Y P++ + K Y ++D+WS+G + F + + + Sbjct: 208 TRWYRAPEIM-------LNSKGYTKSIDIWSVGCILAEMLSNRPIFPG----KHYLDQLN 256 Query: 236 KIITGKPSGAISGVQKAENGPID-WSGDMPVSC-----SLSRGLQVLLTPVLANILEADQ 289 I+ S + + N + +P L +L +L + Sbjct: 257 HILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNP 316 Query: 290 EKCWGFDQFFA 300 K ++ A Sbjct: 317 NKRITVEEALA 327 >4E93-A nrPDB Length = 377 Score = 195 bits (497), Expect = 4e-50, Method: Composition-based stats. Identities = 56/272 (20%), Positives = 104/272 (38%), Gaps = 21/272 (7%) Query: 10 LLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVK 69 +L + +G+G VF GR + L A+K ++E +LK+ +H NIV+ Sbjct: 117 VLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHPNIVR 176 Query: 70 LFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN 129 L + + + ++ME G T L L L ++ D GM +L Sbjct: 177 LIGVCTQ--KQPIYIVMELVQGGDFLTFLRTEGAR--LRVKTLLQMVGDAAAGMEYLESK 232 Query: 130 GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVS---LYGTEEYLHPDMYE 186 +HRD+ N + ++V K++DFG +RE D S ++ P+ Sbjct: 233 CCIHRDLAARNCLVT----EKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEAL- 287 Query: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVMYKIITGKPSGA 245 + +Y + D+WS G+ + + G+ P+ + + V P Sbjct: 288 -------NYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELC 340 Query: 246 ISGVQKAENGPIDWSG-DMPVSCSLSRGLQVL 276 V + + P ++ + LQ + Sbjct: 341 PDAVFRLMEQCWAYEPGQRPSFSTIYQELQSI 372 >4E7W-A nrPDB Length = 394 Score = 195 bits (497), Expect = 4e-50, Method: Composition-based stats. Identities = 58/290 (20%), Positives = 107/290 (36%), Gaps = 24/290 (8%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIV 68 + ++G G+ VF+ + ++ + AIK L+ + RE ++++ + H N+V Sbjct: 42 YTNCKVIGNGSFGVVFQAKLVESDE-VAIKKV-----LQDKRFKNRELQIMRIVKHPNVV 95 Query: 69 KLFAIEEETTTR----HKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 124 L A + L++E+ P +P + + ++ + Sbjct: 96 DLKAFFYSNGDKKDEVFLNLVLEYVPETVYRASRHYAKLKQTMPMLLIKLYMYQLLRSLA 155 Query: 125 HLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDM 184 ++ GI HRDIKP N++ + V KL DFG+A+ L E VS + Y P++ Sbjct: 156 YIHSIGICHRDIKPQNLLL---DPPSGVLKLIDFGSAKILIAGEPNVSYICSRYYRAPEL 212 Query: 185 YERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSG 244 A Y +D+WS G G F G + E++ + G PS Sbjct: 213 IFGAT-------NYTTNIDIWSTGCVMAELMQGQPLFPGESGIDQLVEIIK--VLGTPSR 263 Query: 245 AISGVQKAENGPIDWSGDMP-VSCSLSRGLQVL-LTPVLANILEADQEKC 292 + P + R +++ +LE Sbjct: 264 EQIKTMNPNYMEHKFPQIRPHPFSKVFRPRTPPDAIDLISRLLEYTPSAR 313 >5EFQ-A nrPDB Length = 347 Score = 195 bits (497), Expect = 5e-50, Method: Composition-based stats. Identities = 56/251 (22%), Positives = 107/251 (42%), Gaps = 27/251 (10%) Query: 7 HLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPV-DVQMREFEVLKKLNHK 65 + + I+G+G V++ R K TG++ A+K + +RE ++L++L H+ Sbjct: 11 DKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQ 70 Query: 66 NIVKLFAIEEET--------TTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLR 117 +I+ + I + L+ E+ L +LE S E+ +R Sbjct: 71 SIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDH-DLMGLLE--SGLVHFNENHIKSFMR 127 Query: 118 DVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDE--QFVSLYG 175 ++ G+++ + +HRDIK NI+ + + KL DFG AR +E + + Sbjct: 128 QLMEGLDYCHKKNFLHRDIKCSNILL----NNRGQIKLADFGLARLYSSEESRPYTNKVI 183 Query: 176 TEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMY 235 T Y P++ +++Y +D+WS G T F+ + E++ Sbjct: 184 TLWYRPPELLLG-------EERYTPAIDVWSCGCILGELFTKKPIFQANQE-LAQLELIS 235 Query: 236 KIITGKPSGAI 246 +I G P A+ Sbjct: 236 RI-CGSPCPAV 245 >5GRN-A nrPDB Length = 356 Score = 195 bits (496), Expect = 5e-50, Method: Composition-based stats. Identities = 68/312 (21%), Positives = 112/312 (35%), Gaps = 55/312 (17%) Query: 4 TSNHLWLLSDILGQGATANVFRGR-----HKKTGDLFAIKVFNNISFLRPVDVQMREFEV 58 +L +LG GA V G + A+K+ + M E ++ Sbjct: 43 FPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKI 102 Query: 59 LKKLN-HKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAY------------ 105 + L H NIV L ++ +I E+C G L L + +++ Sbjct: 103 MTHLGPHLNIVNLLGACTKSGP--IYIITEYCFYGDLVNYLHKNRDSFLSHKKKSMLDSE 160 Query: 106 -----------GLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYK 154 GL + L V GM L VHRD+ N++ G+ + K Sbjct: 161 VKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGK----IVK 216 Query: 155 LTDFGAARELEDDEQFVSLYGT---EEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTF 211 + DFG AR++ D +VS T +++ P+ + Y D+WS G+ Sbjct: 217 ICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNL--------YTTLSDVWSYGILL 268 Query: 212 YHAAT-GSLPFRPFEGPRRNKEVMYKIITG----KPSGAISGVQKAENGPIDWSGD-MPV 265 + + G P+ G + KI +G KP A S V + + + P Sbjct: 269 WEIFSLGGTPYP---GMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPS 325 Query: 266 SCSLSRGLQVLL 277 LS ++ LL Sbjct: 326 FYHLSEIVENLL 337 >3UTO-A nrPDB Length = 573 Score = 195 bits (496), Expect = 5e-50, Method: Composition-based stats. Identities = 68/273 (24%), Positives = 108/273 (39%), Gaps = 37/273 (13%) Query: 7 HLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKN 66 + + + LG GA V R + TG+ FA K F + +E + + L H Sbjct: 157 DHYDIHEELGTGAFGVVHRVTERATGNNFAAK-FVMTPHESDKETVRKEIQTMSVLRHPT 215 Query: 67 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 126 +V L E+ V+I EF G L+ + + E E + +R V G+ H+ Sbjct: 216 LVNLHDAFEDDN--EMVMIYEFMSGGELFE--KVADEHNKMSEDEAVEYMRQVCKGLCHM 271 Query: 127 RENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYE 186 EN VH D+KP NIM + KL DFG L+ + GT E+ P++ E Sbjct: 272 HENNYVHLDLKPENIMFTTKRSNE--LKLIDFGLTAHLDPKQSVKVTTGTAEFAAPEVAE 329 Query: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRP---------------------FE 225 + Y D+WS+GV Y +G PF F Sbjct: 330 GKPV-----GYYT---DMWSVGVLSYILLSGLSPFGGENDDETLRNVKSCDWNMDDSAFS 381 Query: 226 GPRRN-KEVMYKIITGKPSGAISGVQKAENGPI 257 G + K+ + K++ P+ ++ Q E+ + Sbjct: 382 GISEDGKDFIRKLLLADPNTRMTIHQALEHPWL 414 >3NYO-A nrPDB Length = 576 Score = 195 bits (496), Expect = 6e-50, Method: Composition-based stats. Identities = 53/243 (21%), Positives = 102/243 (41%), Gaps = 18/243 (7%) Query: 2 QSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQM--REFEVL 59 Q + + + +LG+G V + + TG ++A K + M E ++L Sbjct: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQIL 238 Query: 60 KKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDV 119 +K+N + +V L T L++ G L + A G PE+ + ++ Sbjct: 239 EKVNSRFVVSL--AYAYETKDALCLVLTLMNGGDLKFHIYHMGQA-GFPEARAVFYAAEI 295 Query: 120 VGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEY 179 G+ L IV+RD+KP NI+ D +++D G A + + + GT Y Sbjct: 296 CCGLEDLHRERIVYRDLKPENILL----DDHGHIRISDLGLAVHVPEGQTIKGRVGTVGY 351 Query: 180 LHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIIT 239 + P++ + ++Y + D W++G Y G PF+ + + +EV +++ Sbjct: 352 MAPEVVK--------NERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEV-ERLVK 402 Query: 240 GKP 242 P Sbjct: 403 EVP 405 >1LUF-A nrPDB Length = 343 Score = 195 bits (495), Expect = 7e-50, Method: Composition-based stats. Identities = 65/315 (20%), Positives = 113/315 (35%), Gaps = 65/315 (20%) Query: 5 SNHLWLLSDILGQGATANVFRGRHK-----KTGDLFAIKVFNNISFLRPVDVQMREFEVL 59 + +G+GA VF+ R + + A+K+ + RE ++ Sbjct: 45 PRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALM 104 Query: 60 KKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPS----------------- 102 + ++ NIVKL + + L+ E+ G L L S Sbjct: 105 AEFDNPNIVKLLGVC--AVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRAR 162 Query: 103 ----NAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDF 158 L +E L + R V GM +L E VHRD+ N + V K+ DF Sbjct: 163 VSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVG----ENMVVKIADF 218 Query: 159 GAARELEDDEQFVSLYG---TEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAA 215 G +R + + + + ++ P+ +Y D+W+ GV + Sbjct: 219 GLSRNIYSADYYKADGNDAIPIRWMPPESIF--------YNRYTTESDVWAYGVVLWEIF 270 Query: 216 T-GSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGPID--------WSG---DM 263 + G P+ ++EV+Y + G + + EN P++ WS D Sbjct: 271 SYGLQPYYG----MAHEEVIYYVRDG------NILACPENCPLELYNLMRLCWSKLPADR 320 Query: 264 PVSCSLSRGLQVLLT 278 P CS+ R LQ + Sbjct: 321 PSFCSIHRILQRMCE 335 >3OZ6-A nrPDB Length = 388 Score = 195 bits (495), Expect = 8e-50, Method: Composition-based stats. Identities = 58/334 (17%), Positives = 109/334 (32%), Gaps = 60/334 (17%) Query: 7 HLWLLSDILGQGATANVFRGRHKKTGDLFAIK-VFNNISFLRPVDVQMREFEVLKKLN-H 64 + L LG+GA V++ ++TG++ A+K +F+ RE +L +L+ H Sbjct: 9 RKYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQNSTDAQRTFREIMILTELSGH 68 Query: 65 KNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 124 +NIV L + R L+ ++ T L A L V+ ++ + Sbjct: 69 ENIVNLLNVLRADNDRDVYLVFDYME-----TDLHAVIRANILEPVHKQYVVYQLIKVIK 123 Query: 125 HLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAAREL-------------------- 164 +L G++HRD+KP NI+ + + K+ DFG +R Sbjct: 124 YLHSGGLLHRDMKPSNILL----NAECHVKVADFGLSRSFVNIRRVTNNIPLSINENTEN 179 Query: 165 --EDDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFR 222 +D T Y P++ + KY +D+WS+G G F Sbjct: 180 FDDDQPILTDYVATRWYRAPEILLGST-------KYTKGIDMWSLGCILGEILCGKPIFP 232 Query: 223 PFEGPRRNKEVM-------------------YKIITGKPSGAISGVQKAENGPIDWSGDM 263 + + ++ +I + W + Sbjct: 233 GSSTMNQLERIIGVIDFPSNEDVESIQSPFAKTMIESLKEKVEIRQSNKRDIFTKWKNLL 292 Query: 264 PVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQ 297 +L +L+ + K + Sbjct: 293 LKINP-KADCNEEALDLLDKLLQFNPNKRISAND 325 >4FR4-A nrPDB Length = 384 Score = 194 bits (494), Expect = 8e-50, Method: Composition-based stats. Identities = 50/218 (22%), Positives = 99/218 (45%), Gaps = 16/218 (7%) Query: 7 HLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNH 64 + + +G+G+ V + T ++A+K N + +V+ +E ++++ L H Sbjct: 15 DHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQGLEH 74 Query: 65 KNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 124 +V L+ ++ ++++ G L L++ + E + + ++V ++ Sbjct: 75 PFLVNLWYSFQDEED--MFMVVDLLLGGDLRYHLQQNVH---FKEETVKLFICELVMALD 129 Query: 125 HLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDM 184 +L+ I+HRD+KP NI+ D +TDF A L + Q ++ GT+ Y+ P+M Sbjct: 130 YLQNQRIIHRDMKPDNILL----DEHGHVHITDFNIAAMLPRETQITTMAGTKPYMAPEM 185 Query: 185 YERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFR 222 + Y VD WS+GVT Y G P+ Sbjct: 186 FS-----SRKGAGYSFAVDWWSLGVTAYELLRGRRPYH 218 >2WQN-A nrPDB Length = 310 Score = 194 bits (494), Expect = 9e-50, Method: Composition-based stats. Identities = 53/219 (24%), Positives = 89/219 (40%), Gaps = 18/219 (8%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFN--NISFLRPVDVQMREFEVLKKLNHKN 66 + + +G+G + V+R G A+K ++ + ++E ++LK+LNH N Sbjct: 34 FRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHPN 93 Query: 67 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGL-PESEFLIVLRDVVGGMNH 125 ++K +A E + +++E G L +++ L PE + + H Sbjct: 94 VIKYYASFIEDNELN--IVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEH 151 Query: 126 LRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFV-SLYGTEEYLHPDM 184 + ++HRDIKP N+ V KL D G R SL GT Y+ P+ Sbjct: 152 MHSRRVMHRDIKPANVFIT----ATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPER 207 Query: 185 YERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRP 223 H+ Y D+WS+G Y A PF Sbjct: 208 I--------HENGYNFKSDIWSLGCLLYEMAALQSPFYG 238 >2DQ7-X nrPDB Length = 283 Score = 194 bits (494), Expect = 9e-50, Method: Composition-based stats. Identities = 59/286 (20%), Positives = 107/286 (37%), Gaps = 33/286 (11%) Query: 4 TSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLN 63 L LG G V+ G AIK + + + E +++KKL Sbjct: 6 IPRESLQLIKRLGNGQFGEVWMGTWNGNTK-VAIKTLKPGTM--SPESFLEEAQIMKKLK 62 Query: 64 HKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 123 H +V+L+A+ E ++ E+ GSL L++ L + + V GM Sbjct: 63 HDKLVQLYAVVSEE---PIYIVTEYMNKGSLLDFLKD-GEGRALKLPNLVDMAAQVAAGM 118 Query: 124 NHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTE---EYL 180 ++ +HRD++ NI+ G + K+ DFG AR +ED+E + + G + ++ Sbjct: 119 AYIERMNYIHRDLRSANILVGNG----LICKIADFGLARLIEDNE-YTARQGAKFPIKWT 173 Query: 181 HPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVMYKIIT 239 P+ ++ D+WS G+ T G +P+ N+EV+ ++ Sbjct: 174 APE--------AALYGRFTIKSDVWSFGILLTELVTKGRVPYPG----MNNREVLEQVER 221 Query: 240 GKPSGAISGV-----QKAENGPIDWSGDMPVSCSLSRGLQVLLTPV 280 G + + + P L L+ T Sbjct: 222 GYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTAT 267 >6DBM-A nrPDB Length = 318 Score = 194 bits (493), Expect = 1e-49, Method: Composition-based stats. Identities = 47/210 (22%), Positives = 91/210 (43%), Gaps = 24/210 (11%) Query: 15 LGQGATANV----FRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKL 70 LG+G V + + TG++ A+K + + +E ++L+ L H++I+K Sbjct: 39 LGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAGPQHRSGWKQEIDILRTLYHEHIIKY 98 Query: 71 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 130 E+ L+ME+ P GSL L + + ++ L+ + + GM +L Sbjct: 99 KGCCEDAGAASLQLVMEYVPLGSLRDYL----PRHSIGLAQLLLFAQQICEGMAYLHSQH 154 Query: 131 IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLY----GTEEYLHPDMYE 186 +HRD+ N++ D + K+ DFG A+ + + ++ + + P+ + Sbjct: 155 YIHRDLAARNVLL----DNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLK 210 Query: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAAT 216 + K+ D+WS GVT Y T Sbjct: 211 --------EYKFYYASDVWSFGVTLYELLT 232 >4PDO-A nrPDB Length = 299 Score = 194 bits (493), Expect = 1e-49, Method: Composition-based stats. Identities = 58/276 (21%), Positives = 107/276 (38%), Gaps = 26/276 (9%) Query: 12 SDILGQGATANVFRGRHK-KTGDL---FAIKVFNNISFLRPVDVQMREFEVLKKLNHKNI 67 ++G G V++G K +G AIK + + E ++ + +H NI Sbjct: 39 QKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFSHHNI 98 Query: 68 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 127 ++L + + + ++I E+ G+L L E + + + + +LR + GM +L Sbjct: 99 IRLEGVI--SKYKPMMIITEYMENGALDKFLREKDGEFSV--LQLVGMLRGIAAGMKYLA 154 Query: 128 ENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQ--FVSLYG--TEEYLHPD 183 VHRD+ NI+ + V K++DFG +R LEDD + + + G + P+ Sbjct: 155 NMNYVHRDLAARNILV----NSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPE 210 Query: 184 MYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVMYKIITGKP 242 +K+ + D+WS G+ + T G P+ K + P Sbjct: 211 AIS--------YRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTP 262 Query: 243 SGAISGV-QKAENGPIDWSGDMPVSCSLSRGLQVLL 277 S + Q P + L L+ Sbjct: 263 MDCPSAIYQLMMQCWQQERARRPKFADIVSILDKLI 298 >3FXW-A nrPDB Length = 336 Score = 194 bits (493), Expect = 1e-49, Method: Composition-based stats. Identities = 67/299 (22%), Positives = 119/299 (39%), Gaps = 41/299 (13%) Query: 3 STSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKL 62 + ++ L +LG G V H++TG A+K+ + +E + + Sbjct: 25 AVTDDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLLYDSP------KARQEVDHHWQA 78 Query: 63 NH-KNIVKLFAIEEETT--TRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDV 119 + +IV + + E R ++IME G L++ ++E + E E ++RD+ Sbjct: 79 SGGPHIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGD-QAFTEREAAEIMRDI 137 Query: 120 VGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEY 179 + L + I HRD+KP N++ E +V KLTDFG A+E + + T Y Sbjct: 138 GTAIQFLHSHNIAHRDVKPENLLYTSKEK-DAVLKLTDFGFAKETTQNA-LQTPCYTPYY 195 Query: 180 LHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIIT 239 + P++ +KY + D+WS+GV Y G PF G + + +I Sbjct: 196 VAPEVL--------GPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRL 247 Query: 240 GKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQF 298 G + P +S + L + +L+ D + QF Sbjct: 248 G-----------------QYGFPNPEWSEVSEDAKQL----IRLLLKTDPTERLTITQF 285 >3KRL-A nrPDB Length = 335 Score = 194 bits (493), Expect = 1e-49, Method: Composition-based stats. Identities = 59/299 (19%), Positives = 98/299 (32%), Gaps = 43/299 (14%) Query: 4 TSNHLWLLSDILGQGATANVFRGRHKKTGDL-----FAIKVFNNISFLRPVDVQMREFEV 58 + LG GA V G A+K+ + + + M E ++ Sbjct: 43 FPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKI 102 Query: 59 LKKL-NHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNA------------- 104 + L H+NIV L T ++I E+C G L L Sbjct: 103 MSHLGQHENIVNLLGAC--THGGPVLVITEYCCYGDLLNFLRRKRPPGLEYSYNPSHNPE 160 Query: 105 YGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAAREL 164 L + L V GM L +HRD+ N++ G V K+ DFG AR++ Sbjct: 161 EQLSSRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGH----VAKIGDFGLARDI 216 Query: 165 EDDEQFVSLYGTE---EYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 +D ++ +++ P+ V Y D+WS G+ + + L Sbjct: 217 MNDSNYIVKGNARLPVKWMAPESIFDCV--------YTVQSDVWSYGILLWEIFS--LGL 266 Query: 222 RPFEGPRRNKEVMYKIITG----KPSGAISGVQKAENGPIDWSG-DMPVSCSLSRGLQV 275 P+ G N + + G +P+ A + P + LQ Sbjct: 267 NPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQE 325 >4OLI-A nrPDB Length = 645 Score = 194 bits (492), Expect = 1e-49, Method: Composition-based stats. Identities = 46/210 (21%), Positives = 91/210 (43%), Gaps = 24/210 (11%) Query: 15 LGQGATANV----FRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKL 70 LG+G V + + TG++ A+K + +E ++L+ L H++I+K Sbjct: 361 LGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKY 420 Query: 71 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 130 E+ + L+ME+ P GSL L + + ++ L+ + + GM +L Sbjct: 421 KGCCEDQGEKSLQLVMEYVPLGSLRDYL----PRHSIGLAQLLLFAQQICEGMAYLHSQH 476 Query: 131 IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLY----GTEEYLHPDMYE 186 +HR++ N++ D + K+ DFG A+ + + ++ + + P+ + Sbjct: 477 YIHRNLAARNVLL----DNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLK 532 Query: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAAT 216 + K+ D+WS GVT Y T Sbjct: 533 --------EYKFYYASDVWSFGVTLYELLT 554 Score = 110 bits (275), Expect = 2e-24, Method: Composition-based stats. Identities = 43/279 (15%), Positives = 88/279 (31%), Gaps = 21/279 (7%) Query: 26 GRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIEEETTTRHKVLI 85 GR + +KV + S ++ +++H ++ + + +++ Sbjct: 88 GRDRGQELRVVLKVLDP-SHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGP--ENIMV 144 Query: 86 MEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRV- 144 E+ G L L + V + + +++L +VH ++ NI+ Sbjct: 145 TEYVEHGPLDVWLRRERGHVPMAWKMV--VAQQLASALSYLENKNLVHGNVCGRNILLAR 202 Query: 145 --IGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATV 202 + E KL+D G E+ V +L P+ + Sbjct: 203 LGLAEGTSPFIKLSDPGVGLGALSREERVERI---PWLAPECLPGGANSL------STAM 253 Query: 203 DLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGPIDWSG 261 D W G T G P + KE Y+ P + + + + + Sbjct: 254 DKWGFGATLLEICFDGEAPLQSRSPSE--KEHFYQRQHRLPEPSCPQLATLTSQCLTYEP 311 Query: 262 -DMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFF 299 P ++ R L L LA++L + + F Sbjct: 312 TQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVF 350 >1G3N-A nrPDB Length = 326 Score = 194 bits (492), Expect = 2e-49, Method: Composition-based stats. Identities = 71/299 (23%), Positives = 115/299 (38%), Gaps = 32/299 (10%) Query: 6 NHLWLLSDILGQGATANVFRGRH-KKTGDLFAIKVFNNISFLRPVD-VQMREFEVLKKLN 63 + + +G+GA VF+ R K G A+K + + +RE VL+ L Sbjct: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLE 69 Query: 64 ---HKNIVKLFAIEEETTTR---HKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLR 117 H N+V+LF + + T L+ E L T L++ G+P ++ Sbjct: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEP-GVPTETIKDMMF 127 Query: 118 DVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTE 177 ++ G++ L + +VHRD+KP NI+ KL DFG AR S+ T Sbjct: 128 QLLRGLDFLHSHRVVHRDLKPQNILVT----SSGQIKLADFGLARIYSFQMALTSVVVTL 183 Query: 178 EYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKI 237 Y P++ Q Y VDLWS+G F FR + + + KI Sbjct: 184 WYRAPEVLL--------QSSYATPVDLWSVGCIFAEMFRRKPLFRG----SSDVDQLGKI 231 Query: 238 ITGKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFD 296 + + G+ E+ P D + S S + + + KC F+ Sbjct: 232 LD------VIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFN 284 >1NY3-A nrPDB Length = 400 Score = 194 bits (492), Expect = 2e-49, Method: Composition-based stats. Identities = 58/255 (22%), Positives = 111/255 (43%), Gaps = 22/255 (8%) Query: 3 STSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVL-KK 61 + + + S +LG G V + +K+T + FA+K+ + RE E+ + Sbjct: 58 AIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML------QDCPKARREVELHWRA 111 Query: 62 LNHKNIVKLFAIEEE--TTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDV 119 +IV++ + E + +++ME G L++ +++ + E E +++ + Sbjct: 112 SQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGD-QAFTEREASEIMKSI 170 Query: 120 VGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEY 179 + +L I HRD+KP N + + ++ KLTDFG A+E + T Y Sbjct: 171 GEAIQYLHSINIAHRDVKPEN-LLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYY 229 Query: 180 LHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIIT 239 + P++ +KY + D+WS+GV Y G PF G + + +I Sbjct: 230 VAPEVL--------GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRM 281 Query: 240 GK---PSGAISGVQK 251 G+ P+ S V + Sbjct: 282 GQYEFPNPEWSEVSE 296 >2OZA-A nrPDB Length = 356 Score = 193 bits (491), Expect = 2e-49, Method: Composition-based stats. Identities = 58/255 (22%), Positives = 111/255 (43%), Gaps = 22/255 (8%) Query: 3 STSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVL-KK 61 + + + S +LG G V + +K+T + FA+K+ + RE E+ + Sbjct: 14 AIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML------QDCPKARREVELHWRA 67 Query: 62 LNHKNIVKLFAIEEE--TTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDV 119 +IV++ + E + +++ME G L++ +++ + E E +++ + Sbjct: 68 SQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGD-QAFTEREASEIMKSI 126 Query: 120 VGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEY 179 + +L I HRD+KP N + + ++ KLTDFG A+E + T Y Sbjct: 127 GEAIQYLHSINIAHRDVKPEN-LLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYY 185 Query: 180 LHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIIT 239 + P++ +KY + D+WS+GV Y G PF G + + +I Sbjct: 186 VAPEVL--------GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRM 237 Query: 240 GK---PSGAISGVQK 251 G+ P+ S V + Sbjct: 238 GQYEFPNPEWSEVSE 252 >1U59-A nrPDB Length = 287 Score = 193 bits (491), Expect = 2e-49, Method: Composition-based stats. Identities = 64/254 (25%), Positives = 111/254 (43%), Gaps = 29/254 (11%) Query: 5 SNHLWLLSDI-LGQGATANVFRGRHKKTGDL--FAIKVFNNISFLRPVDVQMREFEVLKK 61 L++DI LG G +V +G ++ AIKV + + MRE +++ + Sbjct: 7 KRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQ 66 Query: 62 LNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVG 121 L++ IV+L + + +L+ME G L+ L +P S +L V Sbjct: 67 LDNPYIVRLIGVCQAEA---LMLVMEMAGGGPLHKFL--VGKREEIPVSNVAELLHQVSM 121 Query: 122 GMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGT----E 177 GM +L E VHRD+ N++ V + K++DFG ++ L D+ + + Sbjct: 122 GMKYLEEKNFVHRDLAARNVLLV----NRHYAKISDFGLSKALGADDSYYTARSAGKWPL 177 Query: 178 EYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVMYK 236 ++ P+ + +K+ + D+WS GVT + A + G P++ +GP EVM Sbjct: 178 KWYAPECI--------NFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGP----EVMAF 225 Query: 237 IITGKPSGAISGVQ 250 I GK Sbjct: 226 IEQGKRMECPPECP 239 >3BBT-B nrPDB Length = 328 Score = 193 bits (491), Expect = 2e-49, Method: Composition-based stats. Identities = 61/244 (25%), Positives = 102/244 (41%), Gaps = 21/244 (8%) Query: 12 SDILGQGATANVFRGRHKKTGDLF----AIKVFNNISFLRPVDVQMREFEVLKKLNHKNI 67 +LG GA V++G G+ AIK+ N + + M E ++ ++H ++ Sbjct: 20 VKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHL 79 Query: 68 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 127 V+L + T + L+ + P G L + E + G L + GM +L Sbjct: 80 VRLLGVCLSPTIQ---LVTQLMPHGCLLEYVHEHKDNIG--SQLLLNWCVQIAKGMMYLE 134 Query: 128 ENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYER 187 E +VHRD+ N++ + K+TDFG AR LE DE+ + G + + Sbjct: 135 ERRLVHRDLAARNVLV----KSPNHVKITDFGLARLLEGDEKEYNADGGKMP-----IKW 185 Query: 188 AVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVMYK-IITGKPSGA 245 L H +K+ D+WS GVT + T G P+ R +++ K +P Sbjct: 186 MALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPT-REIPDLLEKGERLPQPPIC 244 Query: 246 ISGV 249 V Sbjct: 245 TIDV 248 >1KOA-A nrPDB Length = 491 Score = 193 bits (491), Expect = 2e-49, Method: Composition-based stats. Identities = 68/273 (24%), Positives = 108/273 (39%), Gaps = 37/273 (13%) Query: 7 HLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKN 66 + + + LG GA V R + TG+ FA K F + +E + + L H Sbjct: 51 DHYDIHEELGTGAFGVVHRVTERATGNNFAAK-FVMTPHESDKETVRKEIQTMSVLRHPT 109 Query: 67 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 126 +V L E+ V+I EF G L+ + + E E + +R V G+ H+ Sbjct: 110 LVNLHDAFEDDN--EMVMIYEFMSGGELFE--KVADEHNKMSEDEAVEYMRQVCKGLCHM 165 Query: 127 RENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYE 186 EN VH D+KP NIM + KL DFG L+ + GT E+ P++ E Sbjct: 166 HENNYVHLDLKPENIMFTTKRSNE--LKLIDFGLTAHLDPKQSVKVTTGTAEFAAPEVAE 223 Query: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRP---------------------FE 225 + Y D+WS+GV Y +G PF F Sbjct: 224 GKPV-----GYYT---DMWSVGVLSYILLSGLSPFGGENDDETLRNVKSCDWNMDDSAFS 275 Query: 226 GPRRN-KEVMYKIITGKPSGAISGVQKAENGPI 257 G + K+ + K++ P+ ++ Q E+ + Sbjct: 276 GISEDGKDFIRKLLLADPNTRMTIHQALEHPWL 308 >6F3F-A nrPDB Length = 455 Score = 193 bits (490), Expect = 2e-49, Method: Composition-based stats. Identities = 63/286 (22%), Positives = 113/286 (39%), Gaps = 33/286 (11%) Query: 4 TSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLN 63 L LGQG V+ G T AIK + + ++E +V+KKL Sbjct: 184 IPRESLRLEVKLGQGCFGEVWMGTWNGT-TRVAIKTLKPGTM--SPEAFLQEAQVMKKLR 240 Query: 64 HKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 123 H+ +V+L+A+ E ++ E+ GSL L+ + Y L + + + + GM Sbjct: 241 HEKLVQLYAVVSEE---PIYIVTEYMNKGSLLDFLKGETGKY-LRLPQLVDMSAQIASGM 296 Query: 124 NHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTE---EYL 180 ++ VHRD++ NI+ V K+ DFG AR +ED+E + + G + ++ Sbjct: 297 AYVERMNYVHRDLRAANILVG----ENLVCKVADFGLARLIEDNE-YTARQGAKFPIKWT 351 Query: 181 HPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVMYKIIT 239 P+ ++ D+WS G+ T G +P+ N+EV+ ++ Sbjct: 352 APE--------AALYGRFTIKSDVWSFGILLTELTTKGRVPYPG----MVNREVLDQVER 399 Query: 240 GKPSGAISGVQKAEN-----GPIDWSGDMPVSCSLSRGLQVLLTPV 280 G ++ + + P L L+ T Sbjct: 400 GYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTST 445 >3KA0-A nrPDB Length = 320 Score = 193 bits (490), Expect = 3e-49, Method: Composition-based stats. Identities = 58/255 (22%), Positives = 110/255 (43%), Gaps = 22/255 (8%) Query: 3 STSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVL-KK 61 + + + S +LG G V + +K+T + FA+K+ + RE E+ + Sbjct: 12 AIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML------QDCPKARREVELHWRA 65 Query: 62 LNHKNIVKLFAIEEE--TTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDV 119 +IV++ + E + +++ME G L++ +++ + E E +++ + Sbjct: 66 SQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGD-QAFTEREASEIMKSI 124 Query: 120 VGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEY 179 + +L I HRD+KP N + + ++ KLTDFG A+E T Y Sbjct: 125 GEAIQYLHSINIAHRDVKPEN-LLYTSKRPNAILKLTDFGFAKETTSHNSLTEPCYTPYY 183 Query: 180 LHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIIT 239 + P++ +KY + D+WS+GV Y G PF G + + +I Sbjct: 184 VAPEVL--------GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRM 235 Query: 240 GK---PSGAISGVQK 251 G+ P+ S V + Sbjct: 236 GQYEFPNPEWSEVSE 250 >3SXS-A nrPDB Length = 268 Score = 193 bits (490), Expect = 3e-49, Method: Composition-based stats. Identities = 64/286 (22%), Positives = 110/286 (38%), Gaps = 35/286 (12%) Query: 5 SNHLWLLSDILGQGATANVFRGRHKKTGDL-FAIKVFNNISFLRPVDVQMREFEVLKKLN 63 L LG G V G+ K G A+K+ S D +E + + KL+ Sbjct: 6 KREEITLLKELGSGQFGVVKLGKWK--GQYDVAVKMIKEGSMSE--DEFFQEAQTMMKLS 61 Query: 64 HKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 123 H +VK + + + ++ E+ G L L GL S+ L + DV GM Sbjct: 62 HPKLVKFYGVC--SKEYPIYIVTEYISNGCLLNYLRSHGK--GLEPSQLLEMCYDVCEGM 117 Query: 124 NHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTE---EYL 180 L + +HRD+ N + D K++DFG R + DD+ +VS GT+ ++ Sbjct: 118 AFLESHQFIHRDLAARNCLV----DRDLCVKVSDFGMTRYVLDDQ-YVSSVGTKFPVKWS 172 Query: 181 HPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVMYKIIT 239 P+++ H KY + D+W+ G+ + + G +P+ + N EV+ K+ Sbjct: 173 APEVF--------HYFKYSSKSDVWAFGILMWEVFSLGKMPYDLY----TNSEVVLKVSQ 220 Query: 240 GKPSGAISGVQKAE-----NGPIDWSGDMPVSCSLSRGLQVLLTPV 280 G + + P L ++ L Sbjct: 221 GHRLYRPHLASDTIYQIMYSCWHELPEKRPTFQQLLSSIEPLREKD 266 >3ORZ-A nrPDB Length = 316 Score = 193 bits (490), Expect = 3e-49, Method: Composition-based stats. Identities = 59/274 (21%), Positives = 108/274 (39%), Gaps = 23/274 (8%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDV--QMREFEVLKKLNHKN 66 + ILG+G+ + V R T +AIK+ ++ V RE +V+ +L+H Sbjct: 39 FKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPF 98 Query: 67 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 126 VKL+ ++ + L + G L + + + E+ ++V + +L Sbjct: 99 FVKLYFCFQDDEKLYFGL--SYAKNGELLKYIRKIGS---FDETCTRFYTAEIVSALEYL 153 Query: 127 RENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQ---FVSLYGTEEYLHPD 183 GI+HRD+KP NI+ + ++TDFG A+ L + + S GT +Y+ P+ Sbjct: 154 HGKGIIHRDLKPENILL----NEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPE 209 Query: 184 MYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS 243 + + DLW++G Y G PFR ++++ K+ P Sbjct: 210 LLTEKSAC--------KSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKII-KLEYDFPE 260 Query: 244 GAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLL 277 + + + C G L Sbjct: 261 KFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLK 294 >3HKO-A nrPDB Length = 345 Score = 193 bits (490), Expect = 3e-49, Method: Composition-based stats. Identities = 61/276 (22%), Positives = 102/276 (36%), Gaps = 56/276 (20%) Query: 7 HLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFL----RPVDVQMREFEVLKKL 62 + L +GQG+ V +T + AIK+ N + V+ E ++KKL Sbjct: 26 KKYHLKGAIGQGSYGVVRVAIENQTRAIRAIKIMNKNKIRQINPKDVERIKTEVRLMKKL 85 Query: 63 NHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLE----------------------- 99 +H NI +L+ + E+ ++ L+ME C G L L Sbjct: 86 HHPNIARLYEVYED--EQYICLVMELCHGGHLLDKLNVFIDDSTGKCAMDVVKTQICPCP 143 Query: 100 --------------EPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVI 145 S + E ++R + +++L GI HRDIKP N + Sbjct: 144 ECNEEAINGSIHGFRESLDFVQREKLISNIMRQIFSALHYLHNQGICHRDIKPENFLFST 203 Query: 146 GEDGQSVYKLTDFGAARELEDDEQ-----FVSLYGTEEYLHPDMYERAVLRKDHQKKYGA 200 + + KL DFG ++E + GT ++ P++ + YG Sbjct: 204 NKSFE--IKLVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEVLN------TTNESYGP 255 Query: 201 TVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYK 236 D WS GV + G++PF +V+ K Sbjct: 256 KCDAWSAGVLLHLLLMGAVPFPGVNDADTISQVLNK 291 >5G6V-A nrPDB Length = 324 Score = 192 bits (489), Expect = 3e-49, Method: Composition-based stats. Identities = 70/326 (21%), Positives = 127/326 (38%), Gaps = 25/326 (7%) Query: 7 HLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKN 66 ++ D LG+G A V++G+ K T +L A+K +RE +LK L H N Sbjct: 2 ETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHAN 61 Query: 67 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 126 IV L I T + L+ E+ L L++ N + + L ++ G+ + Sbjct: 62 IVTLHDIIH--TEKSLTLVFEYLDK-DLKQYLDDCGNIINMH--NVKLFLFQLLRGLAYC 116 Query: 127 RENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELE-DDEQFVSLYGTEEYLHPDMY 185 ++HRD+KP N++ + + KL DFG AR + + + T Y PD+ Sbjct: 117 HRQKVLHRDLKPQNLLI----NERGELKLADFGLARAKSIPTKTYDNEVVTLWYRPPDIL 172 Query: 186 ERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGA 245 + Y +D+W +G FY ATG F + + + T Sbjct: 173 LGST-------DYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETW 225 Query: 246 ISGVQKAENGPIDWSGDM-PVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQ-----FF 299 + E ++ S + L +L +L+ + + FF Sbjct: 226 PGILSNEEFKTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFF 285 Query: 300 AETSDILHRM--VIHVFSLQQMTAHK 323 + +H++ +F+L+++ K Sbjct: 286 LSLGERIHKLPDTTSIFALKEIQLQK 311 >2OZO-A nrPDB Length = 613 Score = 192 bits (489), Expect = 3e-49, Method: Composition-based stats. Identities = 63/254 (24%), Positives = 111/254 (43%), Gaps = 29/254 (11%) Query: 5 SNHLWLLSDI-LGQGATANVFRGRHKKTGDL--FAIKVFNNISFLRPVDVQMREFEVLKK 61 L++DI LG G +V +G ++ AIKV + + MRE +++ + Sbjct: 333 KRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQ 392 Query: 62 LNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVG 121 L++ IV+L + + +L+ME G L+ L +P S +L V Sbjct: 393 LDNPYIVRLIGVCQAEA---LMLVMEMAGGGPLHKFL--VGKREEIPVSNVAELLHQVSM 447 Query: 122 GMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGT----E 177 GM +L E VHR++ N++ V + K++DFG ++ L D+ + + Sbjct: 448 GMKYLEEKNFVHRNLAARNVLLV----NRHYAKISDFGLSKALGADDSYYTARSAGKWPL 503 Query: 178 EYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVMYK 236 ++ P+ + +K+ + D+WS GVT + A + G P++ +GP EVM Sbjct: 504 KWYAPECI--------NFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGP----EVMAF 551 Query: 237 IITGKPSGAISGVQ 250 I GK Sbjct: 552 IEQGKRMECPPECP 565 >2OU7-A nrPDB Length = 335 Score = 192 bits (489), Expect = 3e-49, Method: Composition-based stats. Identities = 61/211 (28%), Positives = 93/211 (44%), Gaps = 20/211 (9%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMR--EFEVLKKLNHKNIVKLFA 72 LG+G A F T ++FA K+ L+P + E + + L H+++V Sbjct: 49 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 108 Query: 73 IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIV 132 E+ +++E C SL LE L E E LR +V G +L N ++ Sbjct: 109 FFED--NDFVFVVLELCRRRSL---LELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVI 163 Query: 133 HRDIKPGNIMRVIGEDGQSVYKLTDFGAARELE-DDEQFVSLYGTEEYLHPDMYERAVLR 191 HRD+K GN+ + K+ DFG A ++E D E+ L GT Y+ P++ Sbjct: 164 HRDLKLGNLFL----NEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLS----- 214 Query: 192 KDHQKKYGATVDLWSIGVTFYHAATGSLPFR 222 +K + VD+WSIG Y G PF Sbjct: 215 ---KKGHSFEVDVWSIGCIMYTLLVGKPPFE 242 >4KS7-A nrPDB Length = 292 Score = 192 bits (489), Expect = 4e-49, Method: Composition-based stats. Identities = 59/279 (21%), Positives = 115/279 (41%), Gaps = 46/279 (16%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 74 +G+G+T V R K +G A+K+ + + ++ E +++ H N+V+++ + Sbjct: 31 IGEGSTGIVCLAREKHSGRQVAVKMMDLRK-QQRRELLFNEVVIMRDYQHFNVVEMY--K 87 Query: 75 EETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHR 134 ++MEF G+L ++ + L E + V V+ + +L G++HR Sbjct: 88 SYLVGEELWVLMEFLQGGALTDIV----SQVRLNEEQIATVCEAVLQALAYLHAQGVIHR 143 Query: 135 DIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD-EQFVSLYGTEEYLHPDMYERAVLRKD 193 DIK +I+ + KL+DFG ++ D + SL GT ++ P++ R++ Sbjct: 144 DIKSDSILLTLD----GRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSL---- 195 Query: 194 HQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAE 253 Y VD+WS+G+ G P+ + M ++ P K + Sbjct: 196 ----YATEVDIWSLGIMVIEMVDGEPPYF----SDSPVQAMKRLRDSPPP-------KLK 240 Query: 254 NGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKC 292 N S + +L L +L D ++ Sbjct: 241 N---------------SHKVSPVLRDFLERMLVRDPQER 264 >5AMN-A nrPDB Length = 299 Score = 192 bits (489), Expect = 4e-49, Method: Composition-based stats. Identities = 59/291 (20%), Positives = 111/291 (38%), Gaps = 31/291 (10%) Query: 4 TSNHLWLLSDILGQGATANVFRGR-HKKTGD----LFAIKVFNNISFLRPVDVQMREFEV 58 +L LG+G V + G A+K+ + + + EF V Sbjct: 20 FPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNV 79 Query: 59 LKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPS-------NAYGLPESE 111 LK++NH +++KL+ + +LI+E+ GSL L E + L + Sbjct: 80 LKQVNHPHVIKLYGACSQ--DGPLLLIVEYAKYGSLRGFLRESRKVGPGYPDERALTMGD 137 Query: 112 FLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFV 171 + + GM +L E +VHRD+ NI+ G K++DFG +R++ +++ +V Sbjct: 138 LISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKM----KISDFGLSRDVYEEDSYV 193 Query: 172 SLYGTE---EYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGP 227 +++ + + Y D+WS GV + T G P+ Sbjct: 194 KRSQGRIPVKWMAIESLFDHI--------YTTQSDVWSFGVLLWEIVTLGGNPYPGIPPE 245 Query: 228 RRNKEVMYKIITGKPSGAISGVQKAENGPIDWSGD-MPVSCSLSRGLQVLL 277 R + +P + + D PV +S+ L+ ++ Sbjct: 246 RLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMM 296 >2W1I-A nrPDB Length = 326 Score = 192 bits (489), Expect = 4e-49, Method: Composition-based stats. Identities = 59/223 (26%), Positives = 95/223 (42%), Gaps = 24/223 (10%) Query: 2 QSTSNHLWLLSDILGQGATANVFRGRHKK----TGDLFAIKVFNNISFLRPVDVQMREFE 57 Q HL L LG+G +V R+ TG++ A+K + + D + RE E Sbjct: 37 QFEERHLKFLQQ-LGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFE-REIE 94 Query: 58 VLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLR 117 +LK L H NIVK + R+ LIME+ P GSL L++ + + L Sbjct: 95 ILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKER--IDHIKLLQYTS 152 Query: 118 DVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLY--- 174 + GM +L +HRD+ NI+ + ++ K+ DFG + L D+++ + Sbjct: 153 QICKGMEYLGTKRYIHRDLATRNILV----ENENRVKIGDFGLTKVLPQDKEYYKVKEPG 208 Query: 175 -GTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT 216 + P+ + K+ D+WS GV Y T Sbjct: 209 ESPIFWYAPE--------SLTESKFSVASDVWSFGVVLYELFT 243 >2VD5-A nrPDB Length = 412 Score = 192 bits (489), Expect = 4e-49, Method: Composition-based stats. Identities = 71/295 (24%), Positives = 120/295 (40%), Gaps = 13/295 (4%) Query: 6 NHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDV--QMREFEVLKKLN 63 + + ++G+GA + V + K+TG ++A+K+ N L+ +V E +VL + Sbjct: 60 RDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGD 119 Query: 64 HKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 123 + I +L ++ + L+ME+ G L T+L + +P L ++V + Sbjct: 120 RRWITQLHFAFQDEN--YLYLVMEYYVGGDLLTLLSKFGER--IPAEMARFYLAEIVMAI 175 Query: 124 NHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSL--YGTEEYLH 181 + + G VHRDIKP NI+ D +L DFG+ +L D SL GT +YL Sbjct: 176 DSVHRLGYVHRDIKPDNILL----DRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLS 231 Query: 182 PDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 241 P++ + AV YG D W++GV Y G PF ++++ Sbjct: 232 PEILQ-AVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLS 290 Query: 242 PSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFD 296 GV + I P + G T L+ D + Sbjct: 291 LPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPP 345 >3IO7-A nrPDB Length = 313 Score = 192 bits (488), Expect = 4e-49, Method: Composition-based stats. Identities = 59/223 (26%), Positives = 95/223 (42%), Gaps = 24/223 (10%) Query: 2 QSTSNHLWLLSDILGQGATANVFRGRHKK----TGDLFAIKVFNNISFLRPVDVQMREFE 57 Q HL L LG+G +V R+ TG++ A+K + + D + RE E Sbjct: 24 QFEERHLKFLQQ-LGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFE-REIE 81 Query: 58 VLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLR 117 +LK L H NIVK + R+ LIME+ P GSL L++ + + L Sbjct: 82 ILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKER--IDHIKLLQYTS 139 Query: 118 DVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLY--- 174 + GM +L +HRD+ NI+ + ++ K+ DFG + L D+++ + Sbjct: 140 QICKGMEYLGTKRYIHRDLATRNILV----ENENRVKIGDFGLTKVLPQDKEYYKVKEPG 195 Query: 175 -GTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT 216 + P+ + K+ D+WS GV Y T Sbjct: 196 ESPIFWYAPE--------SLTESKFSVASDVWSFGVVLYELFT 230 >4R7H-A nrPDB Length = 343 Score = 192 bits (487), Expect = 5e-49, Method: Composition-based stats. Identities = 59/306 (19%), Positives = 101/306 (33%), Gaps = 50/306 (16%) Query: 4 TSNHLWLLSDILGQGATANVFRGRHKKTGDL-----FAIKVFNNISFLRPVDVQMREFEV 58 + LG GA V G A+K+ + + + M E ++ Sbjct: 47 FPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKI 106 Query: 59 LKKL-NHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEP---------------- 101 + L H+NIV L T ++I E+C G L L Sbjct: 107 MSHLGQHENIVNLLGAC--THGGPVLVITEYCTYGDLLNFLRRKAEAMLGPSLSPGQDPE 164 Query: 102 ----SNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTD 157 + L + L V GM L +HRD+ N++ G V K+ D Sbjct: 165 GLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGH----VAKIGD 220 Query: 158 FGAARELEDDEQFVSLYGTE---EYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHA 214 FG AR++ +D ++ +++ P+ +V Y D+WS G+ + Sbjct: 221 FGLARDIMNDSNYIVKGNARLPVKWMAPESIFDSV--------YTVQSDVWSYGILLWEI 272 Query: 215 ATGSLPFRPFEGPRRNKEVMYKIITG----KPSGAISGVQKAENGPIDWSG-DMPVSCSL 269 + L P+ G N + + G +P+ A + P + Sbjct: 273 FS--LGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQI 330 Query: 270 SRGLQV 275 + LQ Sbjct: 331 TSFLQE 336 >5H2U-A nrPDB Length = 267 Score = 192 bits (487), Expect = 6e-49, Method: Composition-based stats. Identities = 67/279 (24%), Positives = 110/279 (39%), Gaps = 26/279 (9%) Query: 5 SNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNH 64 + L LG G VF G K AIKV + + L + E + +KKL H Sbjct: 4 PREEFTLCRKLGSGYFGEVFEGLWK-DRVQVAIKVISRDNLLHQ-QMLQSEIQAMKKLRH 61 Query: 65 KNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 124 K+I+ L+A+ + +I E GSL +L + S+ LP SE L + V GM Sbjct: 62 KHILALYAVV--SVGDPVYIITELMAKGSLLELLRD-SDEKVLPVSELLDIAWQVAEGMC 118 Query: 125 HLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEE-YLHPD 183 +L +HRD+ NI+ ++ K+ DFG AR +++D + + P+ Sbjct: 119 YLESQNYIHRDLAARNILVG----ENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPE 174 Query: 184 MYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVMYKIITGKP 242 R Y D+WS G+ + + G +P+ N E ++ G Sbjct: 175 ALSR--------GHYSTKSDVWSFGILLHEMFSRGQVPYPG----MSNHEAFLRVDAGYR 222 Query: 243 SGAISGVQKAENGPID--WSGDMPVSCSLSRGLQVLLTP 279 + + + W D P + L+ L+ Sbjct: 223 MPCPLECPPSVHKLMLTCWCRD-PEQRPTFKALRERLSS 260 >4NST-A nrPDB Length = 351 Score = 192 bits (487), Expect = 6e-49, Method: Composition-based stats. Identities = 55/298 (18%), Positives = 111/298 (37%), Gaps = 26/298 (8%) Query: 7 HLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPV-DVQMREFEVLKKLNHK 65 + + I+G+G V++ + K TG+L A+K + +RE ++L++L H+ Sbjct: 13 DKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHR 72 Query: 66 NIVKLFAIEEET--------TTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLR 117 ++V + I + L+ E+ L +LE S E ++ Sbjct: 73 SVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDH-DLMGLLE--SGLVHFSEDHIKSFMK 129 Query: 118 DVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDE--QFVSLYG 175 ++ G+ + + +HRDIK NI+ + KL DFG AR +E + + Sbjct: 130 QLMEGLEYCHKKNFLHRDIKCSNILL----NNSGQIKLADFGLARLYNSEESRPYTNKVI 185 Query: 176 TEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMY 235 T Y P++ +++Y +D+WS G T F+ + + + Sbjct: 186 TLWYRPPELLLG-------EERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISR 238 Query: 236 KIITGKPSGAISGVQKAENGPIDWSG-DMPVSCSLSRGLQVLLTPVLANILEADQEKC 292 + P+ ++ + + +L ++L D K Sbjct: 239 LCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKR 296 >4E20-A nrPDB Length = 290 Score = 191 bits (486), Expect = 7e-49, Method: Composition-based stats. Identities = 52/210 (24%), Positives = 91/210 (43%), Gaps = 24/210 (11%) Query: 15 LGQGATANV----FRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKL 70 LG+G V + + TG++ A+K + RE E+L+ L H++IVK Sbjct: 16 LGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSGWQREIEILRTLYHEHIVKY 75 Query: 71 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 130 E+ + L+ME+ P GSL L P + GL ++ L+ + + GM +L Sbjct: 76 KGCCEDQGEKSVQLVMEYVPLGSLRDYL--PRHCVGL--AQLLLFAQQICEGMAYLHAQH 131 Query: 131 IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLY----GTEEYLHPDMYE 186 +HR + N++ D + K+ DFG A+ + + ++ + + P+ + Sbjct: 132 YIHRALAARNVLL----DNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLK 187 Query: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAAT 216 K+ D+WS GVT Y T Sbjct: 188 EC--------KFYYASDVWSFGVTLYELLT 209 >4AF3-A nrPDB Length = 292 Score = 191 bits (486), Expect = 7e-49, Method: Composition-based stats. Identities = 74/279 (26%), Positives = 121/279 (43%), Gaps = 29/279 (10%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRP-VDVQMR-EFEVLKKLNHKN 66 + + LG+G NV+ R KK+ + A+KV + V+ Q+R E E+ L+H N Sbjct: 25 FEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPN 84 Query: 67 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 126 I++L+ + R LI+E+ P G LY L++ E ++ ++ + + Sbjct: 85 ILRLYNYFYD--RRRIYLILEYAPRGELYKELQKSC---TFDEQRTATIMEELADALMYC 139 Query: 127 RENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYE 186 ++HRDIKP N + + K+ DFG + + ++ GT +YL P+M E Sbjct: 140 HGKKVIHRDIKPEN----LLLGLKGELKIADFGWSVH-APSLRRKTMCGTLDYLPPEMIE 194 Query: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPF---EGPRRNKEVMYKIITGKPS 243 + + VDLW IGV Y G+ PF E RR +V K P+ Sbjct: 195 G--------RMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPT 246 Query: 244 GAISGVQK------AENGPIDWSGDMPVSCSLSRGLQVL 276 GA + K +E P+ P + SR + Sbjct: 247 GAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPP 285 >6FEX-A nrPDB Length = 321 Score = 191 bits (486), Expect = 7e-49, Method: Composition-based stats. Identities = 48/311 (15%), Positives = 92/311 (29%), Gaps = 53/311 (17%) Query: 4 TSNHLWLLSDILGQGATANVFRGR----------------HKKTGDLFAIKVFNNISFLR 47 + LG+G V K L A+K+ + Sbjct: 13 FPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKN 72 Query: 48 PVDVQMREFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEP------ 101 + ++E +++ +L NI++L + + +I ++ G L L Sbjct: 73 ARNDFLKEVKIMSRLKDPNIIRLLGVCVQ--DDPLCMITDYMENGDLNQFLSAHQLEDKA 130 Query: 102 ----SNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTD 157 + L V + GM +L VHRD+ N + K+ D Sbjct: 131 AEGAPGDPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVG----ENFTIKIAD 186 Query: 158 FGAARELEDDEQFV---SLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYH- 213 FG +R L + + ++ + K+ D+W+ GVT + Sbjct: 187 FGMSRNLYAGDYYRVQGRAVLPIRWMAWECILM--------GKFTTASDVWAFGVTLWEV 238 Query: 214 -AATGSLPFRPFEGPRRNK-------EVMYKIITGKPSGAISGVQK-AENGPIDWSGDMP 264 + PF + + + ++ +P G+ + S P Sbjct: 239 LMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRP 298 Query: 265 VSCSLSRGLQV 275 L R L Sbjct: 299 PFSQLHRFLAE 309 >4FIE-A nrPDB Length = 423 Score = 191 bits (486), Expect = 7e-49, Method: Composition-based stats. Identities = 53/230 (23%), Positives = 99/230 (43%), Gaps = 24/230 (10%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 74 +G+G+T V + +G L A+K + + ++ E +++ H+N+V+++ Sbjct: 159 IGEGSTGIVCIATVRSSGKLVAVKKMDLRK-QQRRELLFNEVVIMRDYQHENVVEMYNSY 217 Query: 75 EETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHR 134 ++MEF G+L ++ + E + V V+ ++ L G++HR Sbjct: 218 L--VGDELWVVMEFLEGGALTDIVTHTR----MNEEQIAAVCLAVLQALSVLHAQGVIHR 271 Query: 135 DIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD-EQFVSLYGTEEYLHPDMYERAVLRKD 193 DIK +I+ KL+DFG ++ + + SL GT ++ P++ R Sbjct: 272 DIKSDSILLTHD----GRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRL----- 322 Query: 194 HQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS 243 YG VD+WS+G+ G P+ F P + M I P Sbjct: 323 ---PYGPEVDIWSLGIMVIEMVDGEPPY--FNEPP--LKAMKMIRDNLPP 365 >5KMM-A nrPDB Length = 329 Score = 191 bits (486), Expect = 8e-49, Method: Composition-based stats. Identities = 66/307 (21%), Positives = 103/307 (33%), Gaps = 47/307 (15%) Query: 1 MQSTSNHLWLLSDILGQGATANVFRGRHKK-----TGDLFAIKVFNNISFLRPVDVQMRE 55 + +L LG+GA VF L A+K S RE Sbjct: 29 VHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEAS-ESARQDFQRE 87 Query: 56 FEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSN------------ 103 E+L L H++IV+ F + E R +++ E+ G L L Sbjct: 88 AELLTMLQHQHIVRFFGVCTEG--RPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVA 145 Query: 104 AYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARE 163 L + L V V GM +L VHRD+ N + G V K+ DFG +R+ Sbjct: 146 PGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQG----LVVKIGDFGMSRD 201 Query: 164 LEDDEQFVSLYGT---EEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSL 219 + + + T ++ P+ +K+ D+WS GV + T G Sbjct: 202 IYSTDYYRVGGRTMLPIRWMPPESIL--------YRKFTTESDVWSFGVVLWEIFTYGKQ 253 Query: 220 PFRPFEGPRRNKEVMYKIITG----KPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQV 275 P+ N E + I G +P V G W + P + + Sbjct: 254 PWYQL----SNTEAIDCITQGRELERPRACPPEVYAIMRGC--WQRE-PQQRHSIKDVHA 306 Query: 276 LLTPVLA 282 L + Sbjct: 307 RLQALAQ 313 >5X5O-A nrPDB Length = 310 Score = 191 bits (486), Expect = 9e-49, Method: Composition-based stats. Identities = 60/268 (22%), Positives = 108/268 (40%), Gaps = 34/268 (12%) Query: 16 GQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIEE 75 G G+ +V+R + A+K I +E E+L L+H+NI++ + + Sbjct: 24 GGGSFGSVYRAKWISQDKEVAVKKLLKIE---------KEAEILSVLSHRNIIQFYGVIL 74 Query: 76 ETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN---GIV 132 E ++ E+ GSLY + + + + DV GM++L ++ Sbjct: 75 EPPNYG--IVTEYASLGSLYDYINSNRSEE-MDMDHIMTWATDVAKGMHYLHMEAPVKVI 131 Query: 133 HRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRK 192 HRD+K N++ V K+ DFGA+R + +SL GT ++ P++ + + Sbjct: 132 HRDLKSRNVVIAAD----GVLKICDFGASR-FHNHTTHMSLVGTFPWMAPEVIQSLPV-- 184 Query: 193 DHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK-PSGAISGVQK 251 T D +S GV + T +PF+ EG + V+ K PS + Sbjct: 185 ------SETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAE 238 Query: 252 AENGPIDWSGD---MPVSCSLSRGLQVL 276 + W D P + L+ + Sbjct: 239 LLHQC--WEADAKKRPSFKQIISILESM 264 >4J52-A nrPDB Length = 293 Score = 191 bits (485), Expect = 9e-49, Method: Composition-based stats. Identities = 61/211 (28%), Positives = 93/211 (44%), Gaps = 20/211 (9%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMR--EFEVLKKLNHKNIVKLFA 72 LG+G A F T ++FA K+ L+P + E + + L H+++V Sbjct: 22 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 81 Query: 73 IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIV 132 E+ +++E C SL LE L E E LR +V G +L N ++ Sbjct: 82 FFED--NDFVFVVLELCRRRSL---LELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVI 136 Query: 133 HRDIKPGNIMRVIGEDGQSVYKLTDFGAARELE-DDEQFVSLYGTEEYLHPDMYERAVLR 191 HRD+K GN+ + K+ DFG A ++E D E+ L GT Y+ P++ Sbjct: 137 HRDLKLGNLFL----NEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLS----- 187 Query: 192 KDHQKKYGATVDLWSIGVTFYHAATGSLPFR 222 +K + VD+WSIG Y G PF Sbjct: 188 ---KKGHSFEVDVWSIGCIMYTLLVGKPPFE 215 >5J5T-A nrPDB Length = 370 Score = 191 bits (485), Expect = 9e-49, Method: Composition-based stats. Identities = 67/284 (23%), Positives = 106/284 (37%), Gaps = 26/284 (9%) Query: 5 SNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNH 64 S + L +G G +V++ R+ TG+L AIKV V +E ++K H Sbjct: 2 SQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEP-GEDFAVVQQEIIMMKDCKH 60 Query: 65 KNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 124 NIV F + MEFC GSL + L E + V R+ + G+ Sbjct: 61 PNIVAYFGSYLRRDK--LWICMEFCGGGSLQDIYHVTG---PLSELQIAYVSRETLQGLY 115 Query: 125 HLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD-EQFVSLYGTEEYLHPD 183 +L G +HRDIK NI+ KL DFG + ++ + + GT ++ P+ Sbjct: 116 YLHSKGKMHRDIKGANILLTDN----GHVKLADFGVSAQITATIAKRKAFIGTPYWMAPE 171 Query: 184 MYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS 243 + + + Y DLW++G+T A P P R +M K P Sbjct: 172 VAA-----VERKGGYNQLCDLWAVGITAIELAELQPPMFDL-HPMRALFLMTKSNFQPP- 224 Query: 244 GAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEA 287 + WS ++ P +L+ Sbjct: 225 --------KLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQH 260 >2PL0-A nrPDB Length = 289 Score = 191 bits (485), Expect = 9e-49, Method: Composition-based stats. Identities = 61/282 (21%), Positives = 107/282 (37%), Gaps = 25/282 (8%) Query: 4 TSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLN 63 L + LG G V+ G + A+K S D + E ++K+L Sbjct: 20 VPRETLKLVERLGAGQFGEVWMGYYNGHTK-VAVKSLKQGSM--SPDAFLAEANLMKQLQ 76 Query: 64 HKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 123 H+ +V+L+A+ T +I E+ GSL L+ PS L ++ L + + GM Sbjct: 77 HQRLVRLYAVV---TQEPIYIITEYMENGSLVDFLKTPS-GIKLTINKLLDMAAQIAEGM 132 Query: 124 NHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTE---EYL 180 + E +HRD++ NI+ K+ DFG AR +ED+E + + G + ++ Sbjct: 133 AFIEERNYIHRDLRAANILVS----DTLSCKIADFGLARLIEDNE-YTAREGAKFPIKWT 187 Query: 181 HPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVMYKIIT 239 P+ + + D+WS G+ T G +P+ P + + Sbjct: 188 APEAI--------NYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRM 239 Query: 240 GKPSGAISGVQKAENGPIDWSG-DMPVSCSLSRGLQVLLTPV 280 +P + + D P L L+ T Sbjct: 240 VRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTAT 281 >2W96-B nrPDB Length = 306 Score = 191 bits (485), Expect = 9e-49, Method: Composition-based stats. Identities = 67/287 (23%), Positives = 109/287 (37%), Gaps = 23/287 (8%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDV-QMREFEVLKKLN---HKNIVKL 70 +G GA V++ R +G A+K + + + +RE +L++L H N+V+L Sbjct: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPISTVREVALLRRLEAFEHPNVVRL 71 Query: 71 FAIEEETTTRHKV---LIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 127 + + T ++ L+ E L T L++ GLP ++R + G++ L Sbjct: 72 MDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPP-GLPAETIKDLMRQFLRGLDFLH 129 Query: 128 ENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYER 187 N IVHRD+KP NI+ G KL DFG AR + T Y P++ Sbjct: 130 ANCIVHRDLKPENILVTSG----GTVKLADFGLARIYSYQMALDPVVVTLWYRAPEVLL- 184 Query: 188 AVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAIS 247 Q Y VD+WS+G F F + ++ I P Sbjct: 185 -------QSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLP-PEDDWP 236 Query: 248 GVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWG 294 G G PV + ++ +L +L + K Sbjct: 237 RDVSLPRGAFPPRGPRPVQSVVPE-MEESGAQLLLEMLTFNPHKRIS 282 >4QNY-A nrPDB Length = 354 Score = 191 bits (485), Expect = 9e-49, Method: Composition-based stats. Identities = 68/299 (22%), Positives = 113/299 (37%), Gaps = 28/299 (9%) Query: 6 NHLWLLSDILGQGATANVFRGRH-KKTGDLFAIKVFNNISFLRPV--DVQMREFEVLKKL 62 + +LL I+G G+ V R R K L A+K N F + +RE ++L Sbjct: 19 DDRYLLERIIGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEEVILAKRILREIKLLAHF 78 Query: 63 NHKNIVKLFAIEEETTT---RHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDV 119 N NI+ L I H ++M+ L VL + L E+ + Sbjct: 79 NDDNIIGLRNILTPEDPENFDHFYIVMDIME-TDLKQVLR---SGQELTEAHIQFFIYQA 134 Query: 120 VGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGT-EE 178 + ++ + G++HRDI P NI+ D K+ DFG A+E D ++++ Y T Sbjct: 135 LRALHIIHSAGVIHRDITPANILVNTNCD----LKICDFGLAKEENDQGEYMTDYVTMRW 190 Query: 179 YLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKII 238 Y P++ K Y A +D+W IG GS P + + + +I Sbjct: 191 YRAPELVME-------DKDYSAQIDVWGIGCILGELL-GSRPLFQGKDRVNQLDKIVDVI 242 Query: 239 TGKPSGAISGV--QKAENGPIDWSGDMPVSCSLSR--GLQVLLTPVLANILEADQEKCW 293 G PS A + P + R +L ++L + ++ Sbjct: 243 -GTPSEEDINSVGSSAAQKYLKKKSHRPQADWRQRYPTASPEALDLLRHMLVFNPKRRI 300 >3CJF-A nrPDB Length = 309 Score = 191 bits (485), Expect = 9e-49, Method: Composition-based stats. Identities = 63/299 (21%), Positives = 102/299 (34%), Gaps = 40/299 (13%) Query: 4 TSNHLWLLSDILGQGATANVFRGR-----HKKTGDLFAIKVFNNISFLRPVDVQMREFEV 58 L LG+GA V T A+K+ + M E ++ Sbjct: 24 FPRDRLNLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKI 83 Query: 59 LKKLNHK-NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAY---------GLP 108 L + H N+V L + V++ EFC G+L T L N + L Sbjct: 84 LIHIGHHLNVVNLLGACTKPGGPLMVIV-EFCKFGNLSTYLRSKRNEFVPYKDLYKDFLT 142 Query: 109 ESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDE 168 + V GM L +HRD+ NI+ ++V K+ DFG AR++ D Sbjct: 143 LEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLS----EKNVVKICDFGLARDIYKDP 198 Query: 169 QFVSLYGTE---EYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPF 224 +V +++ P+ + Y D+WS GV + + G+ P+ Sbjct: 199 DYVRKGDARLPLKWMAPETIF--------DRVYTIQSDVWSFGVLLWEIFSLGASPYP-- 248 Query: 225 EGPRRNKEVMYKIITGKPSGAISGV-----QKAENGPIDWSGDMPVSCSLSRGLQVLLT 278 G + ++E ++ G A Q + P L L LL Sbjct: 249 -GVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQ 306 >4JDH-A nrPDB Length = 346 Score = 191 bits (485), Expect = 1e-48, Method: Composition-based stats. Identities = 53/230 (23%), Positives = 99/230 (43%), Gaps = 24/230 (10%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 74 +G+G+T V + +G L A+K + + ++ E +++ H+N+V+++ Sbjct: 82 IGEGSTGIVCIATVRSSGKLVAVKKMDLRK-QQRRELLFNEVVIMRDYQHENVVEMYNSY 140 Query: 75 EETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHR 134 ++MEF G+L ++ + E + V V+ ++ L G++HR Sbjct: 141 L--VGDELWVVMEFLEGGALTDIVTHTR----MNEEQIAAVCLAVLQALSVLHAQGVIHR 194 Query: 135 DIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD-EQFVSLYGTEEYLHPDMYERAVLRKD 193 DIK +I+ KL+DFG ++ + + SL GT ++ P++ R Sbjct: 195 DIKSDSILLTHD----GRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRL----- 245 Query: 194 HQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS 243 YG VD+WS+G+ G P+ F P + M I P Sbjct: 246 ---PYGPEVDIWSLGIMVIEMVDGEPPY--FNEPP--LKAMKMIRDNLPP 288 >4B8L-A nrPDB Length = 286 Score = 190 bits (484), Expect = 1e-48, Method: Composition-based stats. Identities = 63/275 (22%), Positives = 113/275 (41%), Gaps = 38/275 (13%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRP-VDVQMR-EFEVLKKLNHKN 66 + + LG+G NV+ R K+ + A+KV + V+ Q+R E E+ L H N Sbjct: 17 FDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRREIEIQSHLRHPN 76 Query: 67 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 126 I++++ + + L++EF P G LY L++ E + ++ +++ Sbjct: 77 ILRMYNYFHD--RKRIYLMLEFAPRGELYKELQKHGR---FDEQRSATFMEELADALHYC 131 Query: 127 RENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYE 186 E ++HRDIKP N++ + K+ DFG + + ++ GT +YL P+M E Sbjct: 132 HERKVIHRDIKPENLLMGY----KGELKIADFGWSVH-APSLRRRTMCGTLDYLPPEMIE 186 Query: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF------------------RPFEGPR 228 K + VDLW GV Y G PF P Sbjct: 187 G--------KTHDEKVDLWCAGVLCYEFLVGMPPFDSPSHTETHRRIVNVDLKFPPFLSD 238 Query: 229 RNKEVMYKIITGKPSGAISGVQKAENGPIDWSGDM 263 +K+++ K++ P + E+ + + Sbjct: 239 GSKDLISKLLRYHPPQRLPLKGVMEHPWVKANSRR 273 >5HI2-A nrPDB Length = 283 Score = 190 bits (484), Expect = 1e-48, Method: Composition-based stats. Identities = 62/284 (21%), Positives = 109/284 (38%), Gaps = 29/284 (10%) Query: 10 LLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVK 69 + +G G+ V++G+ A+K+ + + E VL+K H NI+ Sbjct: 23 TVGQRIGSGSFGTVYKGKWHGD---VAVKML----TPQQLQAFKNEVGVLRKTRHVNILL 75 Query: 70 LFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN 129 +T ++ ++C SLY L + + + + + R GM++L Sbjct: 76 FMGY---STKPQLAIVTQWCEGSSLYHHLHASETKFEM--KKLIDIARQTARGMDYLHAK 130 Query: 130 GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAAR---ELEDDEQFVSLYGTEEYLHPDMYE 186 I+HRD+K NI + K+ DFG A QF L G+ ++ P++ Sbjct: 131 SIIHRDLKSNNIFL----HEDNTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVI- 185 Query: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAI 246 R Y D+++ G+ Y TG LP+ +++ + G S + Sbjct: 186 ----RMQDSNPYSFQSDVYAFGIVLYELMTGQLPY---SNINNRDQIIEMVGRGSLSPDL 238 Query: 247 SGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQE 290 S V+ N P M R + +LA I E +E Sbjct: 239 SKVRS--NCPKRMKRLMAECLKKKRDERPSFPRILAEIEELARE 280 >2HW6-A nrPDB Length = 307 Score = 190 bits (483), Expect = 2e-48, Method: Composition-based stats. Identities = 66/234 (28%), Positives = 105/234 (44%), Gaps = 20/234 (8%) Query: 3 STSNHLWLL-SDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKK 61 ++ L S++LG+GA A V + G +A+K+ + V RE E L + Sbjct: 8 GKFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVF-REVETLYQ 66 Query: 62 LN-HKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVV 120 +KNI++L E+ T L+ E GS+ +++ + E E V+RDV Sbjct: 67 CQGNKNILELIEFFEDDTR--FYLVFEKLQGGSILAHIQKQKH---FNEREASRVVRDVA 121 Query: 121 GGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDF--GAARELED------DEQFVS 172 ++ L GI HRD+KP NI+ E K+ DF G+ +L + + + Sbjct: 122 AALDFLHTKGIAHRDLKPENILCESPEKVSP-VKICDFDLGSGMKLNNSCTPITTPELTT 180 Query: 173 LYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEG 226 G+ EY+ P++ E + D Y DLWS+GV Y +G PF G Sbjct: 181 PCGSAEYMAPEVVE---VFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCG 231 >3GC0-A nrPDB Length = 329 Score = 190 bits (483), Expect = 2e-48, Method: Composition-based stats. Identities = 64/301 (21%), Positives = 111/301 (36%), Gaps = 27/301 (8%) Query: 3 STSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVD-VQMREFEVLKK 61 +TS + LG+G V++ T + AIK V +RE +LK+ Sbjct: 30 ATSIDRYRRITKLGEGTYGEVYKAIDTVTNETVAIKRIRLEHEEEGVPGTAIREVSLLKE 89 Query: 62 LNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVG 121 L H+NI++L ++ H LI E+ L +++ + + L ++ Sbjct: 90 LQHRNIIELKSVIHHNHRLH--LIFEYAEN-DLKKYMDKNPD---VSMRVIKSFLYQLIN 143 Query: 122 GMNHLRENGIVHRDIKPGNIMRVIGEDGQ-SVYKLTDFGAARELE-DDEQFVSLYGTEEY 179 G+N +HRD+KP N++ + + + V K+ DFG AR QF T Y Sbjct: 144 GVNFCHSRRCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQFTHEIITLWY 203 Query: 180 LHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIIT 239 P++ + + Y +VD+WSI + + F + ++ + Sbjct: 204 RPPEILLGS-------RHYSTSVDIWSIACIWAEMLMKTPLFPGDSEIDQLFKIFEVLGL 256 Query: 240 GKPSGAISGVQKAENGPIDWSGDMPVSC--SLSRGL----QVLLTPVLANILEADQEKCW 293 + DW P +L R L +L +LE D K Sbjct: 257 PDDTTWPGVTALP-----DWKQSFPKFRGKTLKRVLGALLDDEGLDLLTAMLEMDPVKRI 311 Query: 294 G 294 Sbjct: 312 S 312 >4XBR-A nrPDB Length = 366 Score = 190 bits (483), Expect = 2e-48, Method: Composition-based stats. Identities = 53/230 (23%), Positives = 99/230 (43%), Gaps = 24/230 (10%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 74 +G+G+T V + +G L A+K + + ++ E +++ H+N+V+++ Sbjct: 102 IGEGSTGIVCIATVRSSGKLVAVKKMDLRK-QQRRELLFNEVVIMRDYQHENVVEMYNSY 160 Query: 75 EETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHR 134 ++MEF G+L ++ + E + V V+ ++ L G++HR Sbjct: 161 L--VGDELWVVMEFLEGGALTDIVTHTR----MNEEQIAAVCLAVLQALSVLHAQGVIHR 214 Query: 135 DIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD-EQFVSLYGTEEYLHPDMYERAVLRKD 193 DIK +I+ KL+DFG ++ + + SL GT ++ P++ R Sbjct: 215 DIKSDSILLTHD----GRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRL----- 265 Query: 194 HQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS 243 YG VD+WS+G+ G P+ F P + M I P Sbjct: 266 ---PYGPEVDIWSLGIMVIEMVDGEPPY--FNEPP--LKAMKMIRDNLPP 308 >2Q0N-A nrPDB Length = 301 Score = 190 bits (483), Expect = 2e-48, Method: Composition-based stats. Identities = 53/230 (23%), Positives = 99/230 (43%), Gaps = 24/230 (10%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 74 +G+G+T V + +G L A+K + + ++ E +++ H+N+V+++ Sbjct: 37 IGEGSTGIVCIATVRSSGKLVAVKKMDLRK-QQRRELLFNEVVIMRDYQHENVVEMYNSY 95 Query: 75 EETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHR 134 ++MEF G+L ++ + E + V V+ ++ L G++HR Sbjct: 96 L--VGDELWVVMEFLEGGALTDIVTHTR----MNEEQIAAVCLAVLQALSVLHAQGVIHR 149 Query: 135 DIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD-EQFVSLYGTEEYLHPDMYERAVLRKD 193 DIK +I+ KL+DFG ++ + + SL GT ++ P++ R Sbjct: 150 DIKSDSILLTHD----GRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRL----- 200 Query: 194 HQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS 243 YG VD+WS+G+ G P+ F P + M I P Sbjct: 201 ---PYGPEVDIWSLGIMVIEMVDGEPPY--FNEPP--LKAMKMIRDNLPP 243 >5SYS-A nrPDB Length = 286 Score = 190 bits (483), Expect = 2e-48, Method: Composition-based stats. Identities = 64/286 (22%), Positives = 112/286 (39%), Gaps = 31/286 (10%) Query: 4 TSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLN 63 L LGQG + G T AIK + + ++E +V+KKL Sbjct: 15 IPRESLRLEVKLGQGCFGECWMGTWNGT-TRVAIKTLKPGTM--SPEAFLQEAQVMKKLR 71 Query: 64 HKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 123 H+ +V+L+A+ E ++ E+ GSL L+ Y L + + + + GM Sbjct: 72 HEKLVQLYAVVSEE---PIYIVTEYMSKGSLLDFLKGEMGKY-LRLPQLVDMAAQIASGM 127 Query: 124 NHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTE---EYL 180 ++ VHRD++ NI+ V K+ DFG AR +ED+E + + G + ++ Sbjct: 128 AYVERMNYVHRDLRAANILVG----ENLVCKVADFGLARLIEDNE-YTARQGAKFPIKWT 182 Query: 181 HPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVMYKIIT 239 P+ ++ D+WS G+ T G +P+ N+EV+ ++ Sbjct: 183 APE--------AALYGRFTIKSDVWSFGILLTELTTKGRVPYPG----MVNREVLDQVER 230 Query: 240 GKPSGAISGVQKAENG--PIDWSGDMPVSCSLSRGLQVLLTPVLAN 283 G ++ + W D P LQ L + Sbjct: 231 GYRMPCPPECPESLHDLMCQCWRKD-PEERPTFEYLQAFLEDYFTS 275 >5U6C-A nrPDB Length = 315 Score = 190 bits (483), Expect = 2e-48, Method: Composition-based stats. Identities = 58/287 (20%), Positives = 114/287 (39%), Gaps = 21/287 (7%) Query: 6 NHLWLLSDILGQGATANVFRGRHKK---TGDLFAIKVFN-NISFLRPVDVQMREFEVLKK 61 +L +L ILG+G +V G K+ T A+K + S R ++ + E +K Sbjct: 35 RNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKD 94 Query: 62 LNHKNIVKLFAIEEETTTR---HKVLIMEFCPCGSLYTVL---EEPSNAYGLPESEFLIV 115 +H N+++L + E +++ ++I+ F G L+T L + +P L Sbjct: 95 FSHPNVMRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKF 154 Query: 116 LRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYG 175 + D+ GM +L +HRD+ N M + DFG ++++ + + G Sbjct: 155 MVDIALGMEYLSNRNFLHRDLAARNCML----RDDMTVCVADFGLSKKIYSGDYY--RQG 208 Query: 176 TEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVM 234 + + + + Y + D+W+ GVT + AT G P+ + ++ Sbjct: 209 RIAKMP---VKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLL 265 Query: 235 YKIITGKPSGAISGVQKAENGPIDWSG-DMPVSCSLSRGLQVLLTPV 280 + +P + + + D P L L+ LL + Sbjct: 266 HGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESL 312 >3C51-A nrPDB Length = 543 Score = 190 bits (482), Expect = 2e-48, Method: Composition-based stats. Identities = 70/300 (23%), Positives = 117/300 (39%), Gaps = 43/300 (14%) Query: 2 QSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPV--DVQMREFEVL 59 Q +L +LG+G VF + K TG L+A K N + M E ++L Sbjct: 180 QPMGEDWFLDFRVLGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKIL 239 Query: 60 KKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVL-EEPSNAYGLPESEFLIVLRD 118 K++ + IV L E T L+M G + + + G E + Sbjct: 240 AKVHSRFIVSLAYAFETKTD--LCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQ 297 Query: 119 VVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDE-QFVSLYGTE 177 +V G+ HL + I++RD+KP N++ D +++D G A EL+ + + GT Sbjct: 298 IVSGLEHLHQRNIIYRDLKPENVLL----DDDGNVRISDLGLAVELKAGQTKTKGYAGTP 353 Query: 178 EYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKI 237 ++ P++ Y +VD +++GVT Y PFR NKE+ ++ Sbjct: 354 GFMAPELLLGEE--------YDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKQRV 405 Query: 238 ITGKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQ 297 + ++A P +S C +L+ D EK GF Sbjct: 406 L-----------EQAVTYPDKFSPASKDFC--------------EALLQKDPEKRLGFRD 440 >3G0E-A nrPDB Length = 336 Score = 190 bits (482), Expect = 2e-48, Method: Composition-based stats. Identities = 62/313 (19%), Positives = 105/313 (33%), Gaps = 49/313 (15%) Query: 4 TSNHLWLLSDILGQGATANVFRG-----RHKKTGDLFAIKVFNNISFLRPVDVQMREFEV 58 + LG GA V A+K+ + L + M E +V Sbjct: 43 FPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKV 102 Query: 59 LKKL-NHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESE------ 111 L L NH NIV L ++I E+C G L L +++ ++ Sbjct: 103 LSYLGNHMNIVNLLGACTIGGP--TLVITEYCCYGDLLNFLRRKRDSFICSKTSPAIMED 160 Query: 112 ---------FLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAAR 162 L V GM L +HRD+ NI+ G + K+ DFG AR Sbjct: 161 DELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGR----ITKICDFGLAR 216 Query: 163 ELEDDEQFVSLYGTE---EYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GS 218 ++++D +V +++ P+ V Y D+WS G+ + + GS Sbjct: 217 DIKNDSNYVVKGNARLPVKWMAPESIFNCV--------YTFESDVWSYGIFLWELFSLGS 268 Query: 219 LPFRPFEGPRRNKEVMYKIITG----KPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQ 274 P+ + + I G P A + + W D P+ + + Sbjct: 269 SPYPGMP---VDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTC--WDAD-PLKRPTFKQIV 322 Query: 275 VLLTPVLANILEA 287 L+ ++ Sbjct: 323 QLIEKQISESTNH 335 >3OMV-A nrPDB Length = 307 Score = 190 bits (482), Expect = 2e-48, Method: Composition-based stats. Identities = 57/261 (21%), Positives = 103/261 (39%), Gaps = 31/261 (11%) Query: 2 QSTSNHLW-------LLSDILGQGATANVFRGRHKKTGDLFAIKVFNNIS-FLRPVDVQM 53 Q S++ W +LS +G G+ V++G+ A+K+ + Sbjct: 24 QRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGD---VAVKILKVVDPTPEQFQAFR 80 Query: 54 REFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFL 113 E VL+K H NI+ T + ++ ++C SLY L + + + + Sbjct: 81 NEVAVLRKTRHVNILLFMGYM---TKDNLAIVTQWCEGSSLYKHLHVQETKFQM--FQLI 135 Query: 114 IVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAAR---ELEDDEQF 170 + R GM++L I+HRD+K NI G K+ DFG A +Q Sbjct: 136 DIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEG----LTVKIGDFGLATVKSRWSGSQQV 191 Query: 171 VSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRN 230 G+ ++ P++ R + D++S G+ Y TG LP+ Sbjct: 192 EQPTGSVLWMAPEVI-----RMQDNNPFSFQSDVYSYGIVLYELMTGELPY---SHINNR 243 Query: 231 KEVMYKIITGKPSGAISGVQK 251 ++++ + G S +S + K Sbjct: 244 DQIIFMVGRGYASPDLSKLYK 264 >3E7O-A nrPDB Length = 360 Score = 190 bits (482), Expect = 3e-48, Method: Composition-based stats. Identities = 78/370 (21%), Positives = 135/370 (36%), Gaps = 48/370 (12%) Query: 3 STSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVF-NNISFLRPVDVQMREFEVLKK 61 T + +G GA V G A+K RE +LK Sbjct: 18 FTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKC 77 Query: 62 LNHKNIVKLFAIEEETTT----RHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLR 117 +NHKNI+ L + T + L+ME +L V+ L +L Sbjct: 78 VNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIHME-----LDHERMSYLLY 131 Query: 118 DVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTE 177 ++ G+ HL GI+HRD+KP NI+ K+ DFG AR + T Sbjct: 132 QMLCGIKHLHSAGIIHRDLKPSNIVV----KSDCTLKILDFGLARTASTNFMMTPYVVTR 187 Query: 178 EYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKI 237 Y P++ Y VD+WS+G GS+ F+ + + +V+ ++ Sbjct: 188 YYRAPEVILGM--------GYKENVDIWSVGCIMGELVKGSVIFQGTDHIDQWNKVIEQL 239 Query: 238 ITGKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLA-NILEADQEKCWGFD 296 G PS + + ++ + P + + L + + E D+ K Sbjct: 240 --GTPSAEF--MAALQPTVRNYVENRPAYPGI--AFEELFPDWIFPSESERDKIKT---- 289 Query: 297 QFFAETSDILHRMVI----HVFSLQQMTAHKIYIHSYNTA-------TIFHELVYKQTKI 345 ++ D+L +M++ S+ + H Y+ A I+ + ++ Sbjct: 290 ---SQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHA 346 Query: 346 ISSNQELIYE 355 I +ELIY+ Sbjct: 347 IEEWKELIYK 356 >3RAW-A nrPDB Length = 381 Score = 190 bits (482), Expect = 3e-48, Method: Composition-based stats. Identities = 70/356 (19%), Positives = 120/356 (33%), Gaps = 50/356 (14%) Query: 7 HLWLLSDILGQGATANVFRGRHKKTGD-LFAIKVFNNISFLRPVDVQMREFEVLKKL--- 62 + + LG+G V G A+K+ N+ + + E VLKK+ Sbjct: 51 ERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNV--GKYREAARLEINVLKKIKEK 108 Query: 63 NHKNIVKLFAIEEETTTR---HKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDV 119 + +N K + H + E + + L+E N P + + Sbjct: 109 DKEN--KFLCVLMSDWFNFHGHMCIAFELL-GKNTFEFLKEN-NFQPYPLPHVRHMAYQL 164 Query: 120 VGGMNHLRENGIVHRDIKPGNIMRVIGE---------------DGQSVYKLTDFGAAREL 164 + L EN + H D+KP NI+ V E + ++ DFG+A Sbjct: 165 CHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATF- 223 Query: 165 EDDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPF 224 D E ++ T Y P++ + D+WSIG + G F+ Sbjct: 224 -DHEHHTTIVATRHYRPPEVILEL--------GWAQPCDVWSIGCILFEYYRGFTLFQTH 274 Query: 225 EGPRRNKEVMYKIITGKPSGAISGVQKAE---NGPIDWSGDMPVSCSLSRGLQVLLTPVL 281 E R + +M KI+ PS I +K + G + W + + + L + +L Sbjct: 275 EN-REHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYML 333 Query: 282 ANILEADQEKCWGFDQFFAETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHE 337 + LE Q F +L +L + H + FH Sbjct: 334 QDSLEHV--------QLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHT 381 >6BXI-A nrPDB Length = 333 Score = 189 bits (481), Expect = 3e-48, Method: Composition-based stats. Identities = 66/285 (23%), Positives = 112/285 (39%), Gaps = 55/285 (19%) Query: 13 DILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDV--QMREFEVLKKLNHKNIVKL 70 ++G+GA V + K TG ++A+K+ L V E ++L + + +VK+ Sbjct: 12 KVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADSLWVVKM 71 Query: 71 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 130 F ++ + LIMEF P G + T+L + L E E + + V ++ + + G Sbjct: 72 FYSFQD--KLNLYLIMEFLPGGDMMTLLMKKD---TLTEEETQFYIAETVLAIDSIHQLG 126 Query: 131 IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQF-------------------- 170 +HRDIKP N++ D + KL+DFG L+ + Sbjct: 127 FIHRDIKPDNLLL----DSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMN 182 Query: 171 ----------------VSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHA 214 S GT +Y+ P+++ Q Y D WS+GV Y Sbjct: 183 SKRKAETWKRNRRQLAFSTVGTPDYIAPEVFM--------QTGYNKLCDWWSLGVIMYEM 234 Query: 215 ATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGPIDW 259 G PF K+VM T + +KA++ + + Sbjct: 235 LIGYPPFCSETPQETYKKVMNWKETLTFPPEVPISEKAKDLILRF 279 >3PLS-A nrPDB Length = 298 Score = 189 bits (481), Expect = 3e-48, Method: Composition-based stats. Identities = 60/278 (21%), Positives = 107/278 (38%), Gaps = 17/278 (6%) Query: 12 SDILGQGATANVFRGRHKKTGD---LFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIV 68 ++G+G V+ G + AIK + I+ ++ V+ +RE +++ LNH N++ Sbjct: 26 DRVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLNHPNVL 85 Query: 69 KLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE 128 L I VL + + G L + P + + + V GM +L E Sbjct: 86 ALIGIMLPPEGLPHVL-LPYMCHGDLLQFIRSPQRNPTV--KDLISFGLQVARGMEYLAE 142 Query: 129 NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERA 188 VHRD+ N M D K+ DFG AR++ D ++ S+ P + Sbjct: 143 QKFVHRDLAARNCML----DESFTVKVADFGLARDIL-DREYYSVQQHRHARLP--VKWT 195 Query: 189 VLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVMYKIITGKPSGAIS 247 L ++ D+WS GV + T G+ P+R + + +P Sbjct: 196 ALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPD 255 Query: 248 GVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANIL 285 + + W D P R L + +++ +L Sbjct: 256 SLYQVMQQC--WEAD-PAVRPTFRVLVGEVEQIVSALL 290 >6BSD-A nrPDB Length = 876 Score = 189 bits (481), Expect = 3e-48, Method: Composition-based stats. Identities = 48/317 (15%), Positives = 92/317 (29%), Gaps = 59/317 (18%) Query: 4 TSNHLWLLSDILGQGATANVFRGR----------------HKKTGDLFAIKVFNNISFLR 47 + LG+G V K L A+K+ + Sbjct: 568 FPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKN 627 Query: 48 PVDVQMREFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPS----- 102 + ++E +++ +L NI++L + + +I ++ G L L Sbjct: 628 ARNDFLKEVKIMSRLKDPNIIRLLGVCVQ--DDPLCMITDYMENGDLNQFLSAHQLEDKA 685 Query: 103 -----------NAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQS 151 + L V + GM +L VHRD+ N + Sbjct: 686 AEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVG----ENF 741 Query: 152 VYKLTDFGAARELEDDEQFV---SLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIG 208 K+ DFG +R L + + ++ + K+ D+W+ G Sbjct: 742 TIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILM--------GKFTTASDVWAFG 793 Query: 209 VTFYH--AATGSLPFRPFEGPRRNK-------EVMYKIITGKPSGAISGVQK-AENGPID 258 VT + + PF + + + ++ +P G+ + Sbjct: 794 VTLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSR 853 Query: 259 WSGDMPVSCSLSRGLQV 275 S P L R L Sbjct: 854 ESEQRPPFSQLHRFLAE 870 >4XUF-A nrPDB Length = 297 Score = 189 bits (480), Expect = 3e-48, Method: Composition-based stats. Identities = 55/252 (21%), Positives = 88/252 (34%), Gaps = 44/252 (17%) Query: 4 TSNHLWLLSDILGQGATANVFRGRH---KKTGD--LFAIKVFNNISFLRPVDVQMREFEV 58 +LG GA V KTG A+K+ + + M E ++ Sbjct: 6 FPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKM 65 Query: 59 LKKL-NHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPE-------- 109 + +L +H+NIV L T + LI E+C G L L + E Sbjct: 66 MTQLGSHENIVNLLGAC--TLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKR 123 Query: 110 ------------SEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTD 157 + L V GM L VHRD+ N++ G+ V K+ D Sbjct: 124 LEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGK----VVKICD 179 Query: 158 FGAARELEDDEQFVSLYGTE---EYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHA 214 FG AR++ D +V +++ P+ + Y D+WS G+ + Sbjct: 180 FGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGI--------YTIKSDVWSYGILLWEI 231 Query: 215 AT-GSLPFRPFE 225 + G P+ Sbjct: 232 FSLGVNPYPGIP 243 >4HZS-A nrPDB Length = 341 Score = 189 bits (480), Expect = 4e-48, Method: Composition-based stats. Identities = 69/336 (20%), Positives = 122/336 (36%), Gaps = 42/336 (12%) Query: 11 LSDILGQGATANVFRGRHK-KTGDLF--AIKVFNNISFLRP--VDVQMREFEVLKKLNHK 65 L + LG G+ V RG +G A+K +P +D +RE + L+H+ Sbjct: 16 LLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHR 75 Query: 66 NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 125 N+++L+ + + ++ E P GSL L + + L V GM + Sbjct: 76 NLIRLYGVVLTPPMK---MVTELAPLGSLLDRLRKHQGHFLL--GTLSRYAVQVAEGMGY 130 Query: 126 LRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEE----YLH 181 L +HRD+ N++ + + K+ DFG R L ++ + + + Sbjct: 131 LESKRFIHRDLAARNLLLAT----RDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCA 186 Query: 182 PDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVMYKI-IT 239 P+ + + + D W GVT + T G P+ G ++++KI Sbjct: 187 PESLK--------TRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNG----SQILHKIDKE 234 Query: 240 GKPSGAISGVQKAE-NGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQF 298 G+ + N + P L+ L LEA F Sbjct: 235 GERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRDFL-------LEAQPTDMRALQDF 287 Query: 299 FAETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATI 334 E D LH + V ++ + A + NT T+ Sbjct: 288 --EEPDKLHIQMNDVITVIEGRAENYWWRGQNTRTL 321 >5ZTN-A nrPDB Length = 429 Score = 189 bits (479), Expect = 4e-48, Method: Composition-based stats. Identities = 59/266 (22%), Positives = 114/266 (42%), Gaps = 19/266 (7%) Query: 7 HLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNIS-FLRPVDVQMREFEVLKKLNHK 65 + + + ++G+G+ V + K A+K+ N F R ++R E L+K + Sbjct: 97 YRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKD 156 Query: 66 NIVKLFAIEEETTTR-HKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 124 N + + + E T R H + E +LY ++++ G ++ ++ Sbjct: 157 NTMNVIHMLENFTFRNHICMTFELLSM-NLYELIKKNK-FQGFSLPLVRKFAHSILQCLD 214 Query: 125 HLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDM 184 L +N I+H D+KP NI+ + G+S K+ DFG++ + ++ + + Y P++ Sbjct: 215 ALHKNRIIHCDLKPENILL--KQQGRSGIKVIDFGSSC--YEHQRVYTYIQSRFYRAPEV 270 Query: 185 YERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSG 244 A +YG +D+WS+G TG P P E M +++ G PS Sbjct: 271 ILGA--------RYGMPIDMWSLGCILAELLTGY-PLLPGEDEGDQLACMIELL-GMPSQ 320 Query: 245 AISGVQKAENGPIDWSGDMPVSCSLS 270 + K + G P C+++ Sbjct: 321 KLLDASKRAKNFVSSKGY-PRYCTVT 345 >3A4O-X nrPDB Length = 286 Score = 189 bits (479), Expect = 4e-48, Method: Composition-based stats. Identities = 57/286 (19%), Positives = 105/286 (36%), Gaps = 32/286 (11%) Query: 4 TSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLN 63 L LG G V+ G + + A+K + V + E ++K L Sbjct: 10 IPRESIKLVKRLGAGQFGEVWMGYYNNSTK-VAVKTLKPGTM--SVQAFLEEANLMKTLQ 66 Query: 64 HKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 123 H +V+L+A+ +I E+ GSL L+ L + + + GM Sbjct: 67 HDKLVRLYAVVTR--EEPIYIITEYMAKGSLLDFLKSDEGGKVL-LPKLIDFSAQIAEGM 123 Query: 124 NHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTE---EYL 180 ++ +HRD++ N++ + K+ DFG AR +ED+E + + G + ++ Sbjct: 124 AYIERKNYIHRDLRAANVLVS----ESLMCKIADFGLARVIEDNE-YTAREGAKFPIKWT 178 Query: 181 HPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVMYKIIT 239 P+ + + D+WS G+ Y T G +P+ R N +VM + Sbjct: 179 APEAI--------NFGCFTIKSDVWSFGILLYEIVTYGKIPYPG----RTNADVMTALSQ 226 Query: 240 GKPSGAISGVQK-----AENGPIDWSGDMPVSCSLSRGLQVLLTPV 280 G + + + + + P L L T Sbjct: 227 GYRMPRVENCPDELYDIMKMCWKEKAEERPTFDYLQSVLDDFYTAT 272 >3QUP-A nrPDB Length = 323 Score = 189 bits (479), Expect = 5e-48, Method: Composition-based stats. Identities = 60/305 (19%), Positives = 114/305 (37%), Gaps = 32/305 (10%) Query: 4 TSNHLWLLSDILGQGATANVFRGRHKKTG---DLFAIKVFN-NISFLRPVDVQMREFEVL 59 + L +LG+G +V + K+ A+K+ +I ++ +RE + Sbjct: 20 IPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACM 79 Query: 60 KKLNHKNIVKLFAIEEETTTRH----KVLIMEFCPCGSLYTVL---EEPSNAYGLPESEF 112 K+ +H ++ KL + + + ++I+ F G L+ L N + LP Sbjct: 80 KEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTL 139 Query: 113 LIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVS 172 + + D+ GM +L +HRD+ N M + DFG +R++ + + Sbjct: 140 VRFMVDIACGMEYLSSRNFIHRDLAARNCMLAED----MTVCVADFGLSRKIYSGDYYRQ 195 Query: 173 LYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNK 231 ++ + L Y D+W+ GVT + T G P+ E N Sbjct: 196 GCASKLP-----VKWLALESLADNLYTVHSDVWAFGVTMWEIMTRGQTPYAGIE----NA 246 Query: 232 EVMYKIITG----KPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEA 287 E+ +I G +P + V WS D P L++ L +L ++ Sbjct: 247 EIYNYLIGGNRLKQPPECMEEVYDLMYQC--WSAD-PKQRPSFTCLRMELENILGHLSVL 303 Query: 288 DQEKC 292 + Sbjct: 304 STSQD 308 >4PWN-A nrPDB Length = 274 Score = 188 bits (478), Expect = 6e-48, Method: Composition-based stats. Identities = 63/258 (24%), Positives = 107/258 (41%), Gaps = 28/258 (10%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLR-PVDVQMREFEVLKKLNHKNIVKLFAI 73 +G+G+ V++G +T A + + E E+LK L H NIV+ + Sbjct: 18 IGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQHPNIVRFYDS 77 Query: 74 EEET--TTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN-- 129 E T + VL+ E G+L T L+ + R ++ G+ L Sbjct: 78 WESTVKGKKCIVLVTELMTSGTLKTYLKRFK---VMKIKVLRSWCRQILKGLQFLHTRTP 134 Query: 130 GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAV 189 I+HRD+K NI K+ D G A + S+ GT E++ P+MYE Sbjct: 135 PIIHRDLKCDNIFIT---GPTGSVKIGDLGLATLEKRASFAKSVIGTPEFMAPEMYE--- 188 Query: 190 LRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITG-KPSG---- 244 +KY +VD+++ G+ AT P+ + ++ ++ +G KP+ Sbjct: 189 ------EKYDESVDVYAFGMCMLEMATSEYPY---SECQNAAQIYRRVTSGVKPASFDKV 239 Query: 245 AISGVQKAENGPIDWSGD 262 AI V++ G I + D Sbjct: 240 AIPEVKEIIEGCIRQNKD 257 >3TT0-A nrPDB Length = 382 Score = 188 bits (478), Expect = 6e-48, Method: Composition-based stats. Identities = 55/295 (18%), Positives = 98/295 (33%), Gaps = 40/295 (13%) Query: 5 SNHLWLLSDILGQGATANVFRG------RHKKTGD-LFAIKVFNNISFLRPVDVQMREFE 57 +L LG+GA V + K A+K+ + + + + + E E Sbjct: 67 PRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEME 126 Query: 58 VLKKL-NHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNA------------ 104 ++K + HKNI+ L + +I+E+ G+L L+ Sbjct: 127 MMKMIGKHKNIINLLGACTQ--DGPLYVIVEYASKGNLREYLQARRPPGLEYSYNPSHNP 184 Query: 105 -YGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARE 163 L + + V GM +L +HRD+ N++ V K+ DFG AR+ Sbjct: 185 EEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDN----VMKIADFGLARD 240 Query: 164 LEDDEQFVSLYGTE---EYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSL 219 + + + +++ P+ + Y D+WS GV + T G Sbjct: 241 IHHIDYYKKTTNGRLPVKWMAPEALF--------DRIYTHQSDVWSFGVLLWEIFTLGGS 292 Query: 220 PFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGPIDWSGD-MPVSCSLSRGL 273 P+ K + KPS + + P L L Sbjct: 293 PYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 347 >5HIE-A nrPDB Length = 302 Score = 188 bits (478), Expect = 7e-48, Method: Composition-based stats. Identities = 61/278 (21%), Positives = 109/278 (39%), Gaps = 29/278 (10%) Query: 10 LLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVK 69 + +G G+ V++G+ A+K+ + + E VL+K H NI+ Sbjct: 39 TVGQRIGSGSFGTVYKGKWHGD---VAVKML----TPQQLQAFKNEVGVLRKTRHVNILL 91 Query: 70 LFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN 129 +T ++ ++C SLY L + + + + + R GM++L Sbjct: 92 FMGY---STKPQLAIVTQWCEGSSLYHHLHIIETKFEM--IKLIDIARQTAQGMDYLHAK 146 Query: 130 GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAAR---ELEDDEQFVSLYGTEEYLHPDMYE 186 I+HRD+K NI K+ DFG A QF L G+ ++ P++ Sbjct: 147 SIIHRDLKSNNIFL----HEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVI- 201 Query: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAI 246 R + Y D+++ G+ Y TG LP+ ++++ + G S + Sbjct: 202 ----RMQDKNPYSFQSDVYAFGIVLYELMTGQLPY---SNINNRDQIIFMVGRGYLSPDL 254 Query: 247 SGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANI 284 S V+ N P M R + L +LA+I Sbjct: 255 SKVRS--NCPKAMKRLMAECLKKKRDERPLFPQILASI 290 >6DBN-A nrPDB Length = 316 Score = 188 bits (478), Expect = 7e-48, Method: Composition-based stats. Identities = 71/287 (24%), Positives = 115/287 (40%), Gaps = 38/287 (13%) Query: 15 LGQGATANVFRGRHKK----TGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKL 70 LG+G V R+ TG+ A+K S + +E E+L+ L H+NIVK Sbjct: 43 LGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKY 102 Query: 71 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 130 I E LIMEF P GSL L + N L + L + GM++L Sbjct: 103 KGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINL--KQQLKYAVQICKGMDYLGSRQ 160 Query: 131 IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEE----YLHPDMYE 186 VHRD+ N++ + + K+ DFG + +E D+++ ++ + + P+ Sbjct: 161 YVHRDLAARNVLV----ESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLM 216 Query: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAATG----SLP---FRPFEGPRRNKEVMYKII- 238 Q K+ D+WS GVT + T S P F GP + + +++ Sbjct: 217 --------QSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVN 268 Query: 239 ---TGK----PSGAISGVQKAENGPIDWSG-DMPVSCSLSRGLQVLL 277 GK P V + ++ + +L G + LL Sbjct: 269 TLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALL 315 >2HK5-A nrPDB Length = 270 Score = 188 bits (477), Expect = 8e-48, Method: Composition-based stats. Identities = 58/277 (20%), Positives = 100/277 (36%), Gaps = 25/277 (9%) Query: 4 TSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLN 63 L LG G V+ + K A+K S V+ + E V+K L Sbjct: 12 IPRESLKLEKKLGAGQFGEVWMATYNKHTK-VAVKTMKPGSM--SVEAFLAEANVMKTLQ 68 Query: 64 HKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 123 H +VKL A+ T +I EF GSL L+ + P + + + GM Sbjct: 69 HDKLVKLHAVV---TKEPIYIITEFMAKGSLLDFLKSDEGSKQ-PLPKLIDFSAQIAEGM 124 Query: 124 NHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTE---EYL 180 + + +HRD++ NI+ V K+ DFG AR +ED+E + + G + ++ Sbjct: 125 AFIEQRNYIHRDLRAANILVS----ASLVCKIADFGLARVIEDNE-YTAREGAKFPIKWT 179 Query: 181 HPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVMYKIIT 239 P+ + + D+WS G+ T G +P+ P + + Sbjct: 180 APEAI--------NFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRM 231 Query: 240 GKPSGAISGVQK-AENGPIDWSGDMPVSCSLSRGLQV 275 +P + + + P + L Sbjct: 232 PRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDD 268 >5U6B-A nrPDB Length = 307 Score = 188 bits (477), Expect = 8e-48, Method: Composition-based stats. Identities = 59/288 (20%), Positives = 113/288 (39%), Gaps = 29/288 (10%) Query: 6 NHLWLLSDILGQGATANVFRGRHKKTGDL--FAIKVFN-NISFLRPVDVQMREFEVLKKL 62 H L LG+G V G+ + + A+K I ++ + E +K+ Sbjct: 22 RHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEF 81 Query: 63 NHKNIVKLFAIEEETTTRH----KVLIMEFCPCGSLYTVL---EEPSNAYGLPESEFLIV 115 +H N+++L + + + R V+I+ F G L++ L LP + Sbjct: 82 DHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKF 141 Query: 116 LRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYG 175 + D+ GM +L +HRD+ N M + + DFG ++++ + + + G Sbjct: 142 MADIASGMEYLSTKRFIHRDLAARNCML----NENMSVCVADFGLSKKIYNGDYY--RQG 195 Query: 176 TEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVM 234 + + + + Y + D+WS GVT + AT G P+ E N E+ Sbjct: 196 RIAKMP---VKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVE----NSEIY 248 Query: 235 YKIITG----KPSGAISGVQKAENGPIDWSG-DMPVSCSLSRGLQVLL 277 + G +P+ + G+ + + + D P L L+ L Sbjct: 249 DYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELREDLENTL 296 >4HVI-A nrPDB Length = 314 Score = 188 bits (477), Expect = 1e-47, Method: Composition-based stats. Identities = 67/291 (23%), Positives = 107/291 (36%), Gaps = 40/291 (13%) Query: 3 STSNHLWLLSDILGQGATANVFRGRHKK----TGDLFAIKVFNNISFLRPVDVQMREFEV 58 HL +S LG+G +V R+ TG L A+K + + D Q RE ++ Sbjct: 7 FEERHLKYISQ-LGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQ-REIQI 64 Query: 59 LKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRD 118 LK L+ IVK + + L+ME+ P G L L+ L S L+ Sbjct: 65 LKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRAR--LDASRLLLYSSQ 122 Query: 119 VVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSL----Y 174 + GM +L VHRD+ NI+ + ++ K+ DFG A+ L D+ + + Sbjct: 123 ICKGMEYLGSRRCVHRDLAARNILV----ESEAHVKIADFGLAKLLPLDKDYYVVREPGQ 178 Query: 175 GTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATG----SLP---FRPFEGP 227 + P+ + + D+WS GV Y T P F G Sbjct: 179 SPIFWYAPESLSDNI--------FSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGS 230 Query: 228 RRNKEVMYKI--------ITGKPSGAISGVQKAENGPIDWSG-DMPVSCSL 269 R+ + ++ P + V + S D P +L Sbjct: 231 ERDVPALSRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSAL 281 >4YHJ-A nrPDB Length = 584 Score = 187 bits (476), Expect = 1e-47, Method: Composition-based stats. Identities = 58/273 (21%), Positives = 108/273 (39%), Gaps = 21/273 (7%) Query: 2 QSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQM--REFEVL 59 ++T H +LG+G V + + TG ++A K + M E +L Sbjct: 184 KNTFRHY----RVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRIL 239 Query: 60 KKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDV 119 +K+ + +V L T L++ G L + N G E + ++ Sbjct: 240 EKVQSRFVVSL--AYAYETKDALCLVLTIMNGGDLKFHIYNLGNP-GFDEQRAVFYAAEL 296 Query: 120 VGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEY 179 G+ L+ IV+RD+KP NI+ D + +++D G A E+ + ++ GT Y Sbjct: 297 CCGLEDLQRERIVYRDLKPENILL----DDRGHIRISDLGLATEIPEGQRVRGRVGTVGY 352 Query: 180 LHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIIT 239 + P++ + +KY + D W +G Y G PF+ ++ + +EV +I Sbjct: 353 MAPEVV--------NNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKN 404 Query: 240 GKPSGAISGVQKAENGPIDWSGDMPVSCSLSRG 272 + + A++ P RG Sbjct: 405 DTEEYSEKFSEDAKSICRMLLTKNPSKRLGCRG 437 >5X02-A nrPDB Length = 347 Score = 187 bits (476), Expect = 1e-47, Method: Composition-based stats. Identities = 55/252 (21%), Positives = 88/252 (34%), Gaps = 44/252 (17%) Query: 4 TSNHLWLLSDILGQGATANVFRGRH---KKTGD--LFAIKVFNNISFLRPVDVQMREFEV 58 +LG GA V KTG A+K+ + + M E ++ Sbjct: 45 FPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKM 104 Query: 59 LKKL-NHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPE-------- 109 + +L +H+NIV L T + LI E+C G L L + E Sbjct: 105 MTQLGSHENIVNLLGAC--TLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKR 162 Query: 110 ------------SEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTD 157 + L V GM L VHRD+ N++ G+ V K+ D Sbjct: 163 LEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGK----VVKICD 218 Query: 158 FGAARELEDDEQFVSLYGTE---EYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHA 214 FG AR++ D +V +++ P+ + Y D+WS G+ + Sbjct: 219 FGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGI--------YTIKSDVWSYGILLWEI 270 Query: 215 AT-GSLPFRPFE 225 + G P+ Sbjct: 271 FSLGVNPYPGIP 282 >5LOH-A nrPDB Length = 341 Score = 187 bits (476), Expect = 1e-47, Method: Composition-based stats. Identities = 53/237 (22%), Positives = 100/237 (42%), Gaps = 28/237 (11%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRP--VDVQMREFEVLKKLNHKN 66 + + + +GA V+ G+ K G L+A+KV + E + L Sbjct: 38 FSIVKPISRGAFGKVYLGQ--KGGKLYAVKVVKKADMINKNMTHQVQAERDALALSKSPF 95 Query: 67 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 126 IV L+ + + L+ME+ G + ++L E + + +V +++L Sbjct: 96 IVHLYYSLQSAN--NVYLVMEYLIGGDVKSLLHIYG---YFDEEMAVKYISEVALALDYL 150 Query: 127 RENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAAR-------ELEDDEQFVSLYGTEEY 179 +GI+HRD+KP N++ + KLTDFG ++ + D + GT +Y Sbjct: 151 HRHGIIHRDLKPDNMLIS----NEGHIKLTDFGLSKVTLNRDINMMDILTTRTFCGTPDY 206 Query: 180 LHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYK 236 L P++ + +G VD W++GV + TG PF + + ++ + Sbjct: 207 LAPELLLG--------RAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKR 255 >5A46-A nrPDB Length = 386 Score = 187 bits (476), Expect = 1e-47, Method: Composition-based stats. Identities = 54/295 (18%), Positives = 97/295 (32%), Gaps = 40/295 (13%) Query: 5 SNHLWLLSDILGQGATANVFRG------RHKKTGD-LFAIKVFNNISFLRPVDVQMREFE 57 +L LG+G V + K A+K+ + + + + + E E Sbjct: 38 PRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEME 97 Query: 58 VLKKL-NHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNA------------ 104 ++K + HKNI+ L + +I+E+ G+L L+ Sbjct: 98 MMKMIGKHKNIINLLGACTQ--DGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNP 155 Query: 105 -YGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARE 163 L + + V GM +L +HRD+ N++ V K+ DFG AR+ Sbjct: 156 EEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDN----VMKIADFGLARD 211 Query: 164 LEDDEQFVSLYGTE---EYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSL 219 + + + +++ P+ + Y D+WS GV + T G Sbjct: 212 IHHIDYYKKTTNGRLPVKWMAPEALF--------DRIYTHQSDVWSFGVLLWEIFTLGGS 263 Query: 220 PFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGPIDWSGD-MPVSCSLSRGL 273 P+ K + KPS + + P L L Sbjct: 264 PYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 318 >4XCU-A nrPDB Length = 300 Score = 187 bits (476), Expect = 1e-47, Method: Composition-based stats. Identities = 53/294 (18%), Positives = 95/294 (32%), Gaps = 31/294 (10%) Query: 4 TSNHLWLLSDILGQGATANVFRGR-------HKKTGDLFAIKVFNNISFLRPVDVQMREF 56 +L LG+G V R A+K+ + + + + + E Sbjct: 14 FPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEM 73 Query: 57 EVLKKL-NHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPS----NAYGLPESE 111 EV+K + HKNI+ L + + +I+E G+L L + L Sbjct: 74 EVMKLIGRHKNIINLLGVCTQEGP--LYVIVECAAKGNLREFLRARRPPGSSEGPLSFPV 131 Query: 112 FLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFV 171 + V GM +L +HRD+ N++ V K+ DFG AR + + + Sbjct: 132 LVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDN----VMKIADFGLARGVHHIDYYK 187 Query: 172 SLYGTE---EYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGP 227 +++ P+ + Y D+WS G+ + T G P+ Sbjct: 188 KTSNGRLPVKWMAPEALF--------DRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVE 239 Query: 228 RRNKEVMYKIITGKPSGAISGVQKAENGPIDWSGD-MPVSCSLSRGLQVLLTPV 280 + +P + + P L L +L V Sbjct: 240 ELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAV 293 >5FM2-A nrPDB Length = 355 Score = 187 bits (476), Expect = 1e-47, Method: Composition-based stats. Identities = 59/305 (19%), Positives = 111/305 (36%), Gaps = 45/305 (14%) Query: 4 TSNHLWLLSDILGQGATANVFRGR-HKKTGD----LFAIKVFNNISFLRPVDVQMREFEV 58 +L LG+G V + G A+K+ + + + EF V Sbjct: 61 FPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNV 120 Query: 59 LKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEE------------------ 100 LK++NH +++KL+ + +LI+E+ GSL L E Sbjct: 121 LKQVNHPHVIKLYGACSQ--DGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSS 178 Query: 101 ---PSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTD 157 + L + + + GM +L E +VHRD+ NI+ G K++D Sbjct: 179 SLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKM----KISD 234 Query: 158 FGAARELEDDEQFVSLYGTE---EYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHA 214 FG +R++ +++ +V +++ + + Y D+WS GV + Sbjct: 235 FGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHI--------YTTQSDVWSFGVLLWEI 286 Query: 215 AT-GSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGPIDWSGD-MPVSCSLSRG 272 T G P+ R + +P + + D PV +S+ Sbjct: 287 VTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKD 346 Query: 273 LQVLL 277 L+ ++ Sbjct: 347 LEKMM 351 >3EB0-A nrPDB Length = 383 Score = 187 bits (476), Expect = 1e-47, Method: Composition-based stats. Identities = 70/329 (21%), Positives = 118/329 (35%), Gaps = 53/329 (16%) Query: 4 TSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLN 63 TS+ + L LG G+ V ++G FA+K L+ + RE +++K L+ Sbjct: 4 TSSKKYSLGKTLGTGSFGIVCEVFDIESGKRFALKKV-----LQDPRYKNRELDIMKVLD 58 Query: 64 HKNIVKLFAIEEETTT------------------------------------RHKVLIME 87 H NI+KL T ++ +IME Sbjct: 59 HVNIIKLVDYFYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNVIME 118 Query: 88 FCPCGSLYTVLEE-PSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIG 146 + P +L+ VL+ + +P + I + + + + GI HRDIKP N++ Sbjct: 119 YVP-DTLHKVLKSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLLVNSK 177 Query: 147 EDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWS 206 ++ KL DFG+A++L E V+ + Y P++ A +Y ++DLWS Sbjct: 178 DN---TLKLCDFGSAKKLIPSEPSVAYICSRFYRAPELMLGAT-------EYTPSIDLWS 227 Query: 207 IGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGPIDWSGDMPVS 266 IG F G F + ++ + T I Sbjct: 228 IGCVFGELILGKPLFSGETSIDQLVRIIQIMGTPTKEQMIRMNPHYTEVRFPTLKAKDWR 287 Query: 267 CSLSRGLQVLLTPVLANILEADQEKCWGF 295 L G L +L IL + + Sbjct: 288 KILPEGTPSLAIDLLEQILRYEPDLRINP 316 >3GQL-A nrPDB Length = 326 Score = 187 bits (475), Expect = 1e-47, Method: Composition-based stats. Identities = 55/295 (18%), Positives = 98/295 (33%), Gaps = 40/295 (13%) Query: 5 SNHLWLLSDILGQGATANVFRG------RHKKTGD-LFAIKVFNNISFLRPVDVQMREFE 57 +L LG+GA V + K A+K+ + + + + + E E Sbjct: 26 PRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEME 85 Query: 58 VLKKL-NHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNA------------ 104 ++K + HKNI+ L + +I+E+ G+L L+ Sbjct: 86 MMKMIGKHKNIINLLGACTQ--DGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNP 143 Query: 105 -YGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARE 163 L + + V GM +L +HRD+ N++ V K+ DFG AR+ Sbjct: 144 EEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDN----VMKIADFGLARD 199 Query: 164 LEDDEQFVSLYGTE---EYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSL 219 + + + +++ P+ + Y D+WS GV + T G Sbjct: 200 IHHIDYYKKTTNGRLPVKWMAPEALF--------DRIYTHQSDVWSFGVLLWEIFTLGGS 251 Query: 220 PFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGPIDWSGD-MPVSCSLSRGL 273 P+ K + KPS + + P L L Sbjct: 252 PYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 306 >4XLV-A nrPDB Length = 328 Score = 187 bits (475), Expect = 1e-47, Method: Composition-based stats. Identities = 57/297 (19%), Positives = 108/297 (36%), Gaps = 39/297 (13%) Query: 4 TSNHLWLLSDILGQGATANVFR--GRHKKTGD---LFAIKVFNNISFLRPVDVQMREFEV 58 S L LGQG+ V+ R G+ A+K N + LR + E V Sbjct: 36 VSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASV 95 Query: 59 LKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPS-------NAYGLPESE 111 +K ++V+L + + + +++ME G L + L E Sbjct: 96 MKGFTCHHVVRLLGVV--SKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQE 153 Query: 112 FLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFV 171 + + ++ GM +L VHRD+ N M K+ DFG R++ + + + Sbjct: 154 MIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHD----FTVKIGDFGMTRDIYETDYYR 209 Query: 172 SLYGTE---EYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGP 227 ++ P+ + V + + D+WS GV + + P++ Sbjct: 210 KGGKGLLPVRWMAPESLKDGV--------FTTSSDMWSFGVVLWEITSLAEQPYQGL--- 258 Query: 228 RRNKEVMYKIITG----KPSGAISGVQKAENGPIDWSGDM-PVSCSLSRGLQVLLTP 279 N++V+ ++ G +P V ++ +M P + L+ L P Sbjct: 259 -SNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPNMRPTFLEIVNLLKDDLHP 314 >5Y86-A nrPDB Length = 588 Score = 187 bits (475), Expect = 1e-47, Method: Composition-based stats. Identities = 56/268 (20%), Positives = 108/268 (40%), Gaps = 23/268 (8%) Query: 7 HLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNIS-FLRPVDVQMREFEVLKKLN-- 63 + + + I+G+G+ V R K A+K+ N F R ++R E LKK + Sbjct: 207 YRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKT 266 Query: 64 -HKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGG 122 N++ + H + E LY ++++ G + ++ Sbjct: 267 GSMNVIHMLESFTFRN--HVCMAFELLSI-DLYELIKKNK-FQGFSVQLVRKFAQSILQS 322 Query: 123 MNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHP 182 ++ L +N I+H D+KP NI+ G+S K+ DFG++ + ++ + + Y P Sbjct: 323 LDALHKNKIIHCDLKPENILL--KHHGRSSTKVIDFGSSCF--EYQKLYTYIQSRFYRAP 378 Query: 183 DMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKP 242 ++ + +Y +D+WS G TG F + + +M + G P Sbjct: 379 EIILGS--------RYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMME--LLGMP 428 Query: 243 SGAISGVQKAENGPIDWSGDMPVSCSLS 270 + K I+ G +P CS++ Sbjct: 429 PPKLLEQSKRAKYFINSKG-IPRYCSVT 455 >3I81-A nrPDB Length = 315 Score = 187 bits (474), Expect = 2e-47, Method: Composition-based stats. Identities = 58/291 (19%), Positives = 109/291 (37%), Gaps = 31/291 (10%) Query: 6 NHLWLLSDILGQGATANVFRGRHK-----KTGDLFAIKVFNNISFLRPVDVQMREFEVLK 60 +S LGQG+ V+ G K + AIK N + +R + E V+K Sbjct: 17 REKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMK 76 Query: 61 KLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAY-------GLPESEFL 113 + N ++V+L + + + ++IME G L + L S+ + Sbjct: 77 EFNCHHVVRLLGVVSQG--QPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMI 134 Query: 114 IVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSL 173 + ++ GM +L N VHRD+ N M K+ DFG R++ + + + Sbjct: 135 QMAGEIADGMAYLNANKFVHRDLAARNCMVAED----FTVKIGDFGMTRDIYETDYYRKG 190 Query: 174 YGTE---EYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRR 229 ++ P+ + V + D+WS GV + AT P++ + Sbjct: 191 GKGLLPVRWMSPESLKDGV--------FTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQV 242 Query: 230 NKEVMYKIITGKPSGAISGVQKAENGPIDWSGDM-PVSCSLSRGLQVLLTP 279 + VM + KP + + ++ M P + ++ + P Sbjct: 243 LRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEP 293 >5UUU-A nrPDB Length = 547 Score = 186 bits (473), Expect = 2e-47, Method: Composition-based stats. Identities = 54/287 (18%), Positives = 113/287 (39%), Gaps = 25/287 (8%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNI--SFLRPVDVQMREFEVLKKL---N 63 + + I+G+G V+ R TG ++A+K + + + + E +L + + Sbjct: 200 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 259 Query: 64 HKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 123 IV + T I++ G L+ L + E++ +++ G+ Sbjct: 260 CPFIVCMSYAFH--TPDKLSFILDLMNGGDLHYHLSQHG---VFSEADMRFYAAEIILGL 314 Query: 124 NHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPD 183 H+ +V+RD+KP NI+ D +++D G A + + S GT Y+ P+ Sbjct: 315 EHMHNRFVVYRDLKPANILL----DEHGHVRISDLGLACDFSKKKPHAS-VGTHGYMAPE 369 Query: 184 MYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNK--EVMYKIITGK 241 + ++ V Y ++ D +S+G + G PFR + +++ + + Sbjct: 370 VLQKGVA-------YDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVEL 422 Query: 242 PSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEAD 288 P ++ G + + + C L RG Q + L+ Sbjct: 423 PDSFSPELRSLLEGLLQRDVNRRLGC-LGRGAQEVKESPFFRSLDWQ 468 >2XS0-A nrPDB Length = 386 Score = 186 bits (472), Expect = 3e-47, Method: Composition-based stats. Identities = 64/313 (20%), Positives = 106/313 (33%), Gaps = 36/313 (11%) Query: 3 STSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVF-NNISFLRPVDVQMREFEVLKK 61 T + +G GA V AIK RE ++K Sbjct: 22 FTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKC 81 Query: 62 LNHKNIVKLFAIEEETTT----RHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLR 117 +NHKNI+ L + + + ++ME +L V++ L +L Sbjct: 82 VNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDA-NLCQVIQME-----LDHERMSYLLY 135 Query: 118 DVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTE 177 ++ G+ HL GI+HRD+KP NI+ K+ DFG AR V T Sbjct: 136 QMLCGIKHLHSAGIIHRDLKPSNIVV----KSDCTLKILDFGLARTAGTSFMMVPFVVTR 191 Query: 178 EYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKI 237 Y P++ Y VD+WS+G G + F + + +V+ ++ Sbjct: 192 YYRAPEVILGM--------GYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQL 243 Query: 238 ITGKPSGA---ISGVQKAENGPIDWSGDM----------PVSCSLSRGLQVLLTPVLANI 284 T P V+ ++G P ++ +L+ + Sbjct: 244 GTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKM 303 Query: 285 LEADQEKCWGFDQ 297 L D K D+ Sbjct: 304 LVIDASKRISVDE 316 >3ORP-A nrPDB Length = 311 Score = 186 bits (472), Expect = 3e-47, Method: Composition-based stats. Identities = 62/245 (25%), Positives = 97/245 (39%), Gaps = 27/245 (11%) Query: 6 NHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPV--DVQMREFEVLKKLN 63 + + L +ILG G + V R + A+KV P RE + LN Sbjct: 11 SDRYELGEILGFGGMSEVHLARDLRDHRDVAVKVLRADLARDPSFYLRFRREAQNAAALN 70 Query: 64 HKNIVKLFAIEEETTT--RHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVG 121 H IV ++ E T ++ME+ +L ++ + + V+ D Sbjct: 71 HPAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVHTEG---PMTPKRAIEVIADACQ 127 Query: 122 GMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVS----LYGTE 177 +N +NGI+HRD+KP NIM + K+ DFG AR + D V+ + GT Sbjct: 128 ALNFSHQNGIIHRDVKPANIMIS----ATNAVKVMDFGIARAIADSGNSVTQTAAVIGTA 183 Query: 178 EYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKI 237 +YL P+ + A D++S+G Y TG PF V Y+ Sbjct: 184 QYLSPEQARGDSV--------DARSDVYSLGCVLYEVLTGEPPFTGDSPVS----VAYQH 231 Query: 238 ITGKP 242 + P Sbjct: 232 VREDP 236 >3PP0-A nrPDB Length = 338 Score = 185 bits (471), Expect = 5e-47, Method: Composition-based stats. Identities = 59/267 (22%), Positives = 102/267 (38%), Gaps = 22/267 (8%) Query: 12 SDILGQGATANVFRGRHKKTGD----LFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNI 67 +LG GA V++G G+ AIKV + + + E V+ + + Sbjct: 22 VKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYV 81 Query: 68 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 127 +L I +T + L+ + P G L + E L + L + GM++L Sbjct: 82 SRLLGICLTSTVQ---LVTQLMPYGCLLDHVRENRGR--LGSQDLLNWCMQIAKGMSYLE 136 Query: 128 ENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYER 187 + +VHRD+ N++ + K+TDFG AR L+ DE G + + Sbjct: 137 DVRLVHRDLAARNVLV----KSPNHVKITDFGLARLLDIDETEYHADGGKVP-----IKW 187 Query: 188 AVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVMYK-IITGKPSGA 245 L ++++ D+WS GVT + T G+ P+ R +++ K +P Sbjct: 188 MALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPA-REIPDLLEKGERLPQPPIC 246 Query: 246 ISGVQK-AENGPIDWSGDMPVSCSLSR 271 V + S P L Sbjct: 247 TIDVYMIMVKCWMIDSECRPRFRELVS 273 >3ZBF-A nrPDB Length = 322 Score = 185 bits (470), Expect = 5e-47, Method: Composition-based stats. Identities = 57/302 (18%), Positives = 108/302 (35%), Gaps = 34/302 (11%) Query: 3 STSNHLWLLSDILGQGATANVFRGRHKK-----TGDL-FAIKVFNNISFLRPVDVQMREF 56 + L +LG GA V+ G +G++ A+K S + ++E Sbjct: 29 AFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEA 88 Query: 57 EVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPE----SEF 112 ++ K NH NI+K + + +I+E G L T L + A + Sbjct: 89 HLMSKFNHPNILKQLGVCL--LNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDL 146 Query: 113 LIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGE-DGQSVYKLTDFGAARELEDDEQFV 171 + + D+ G +L +HRD+ N + + + + K+ DFG AR++ ++ + Sbjct: 147 VDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYR 206 Query: 172 SLYGTE---EYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGP 227 ++ P+ + + D+WS G+ + T G P+ Sbjct: 207 KRGEGLLPVRWMAPESLMDGI--------FTTQSDVWSFGILIWEILTLGHQPYPAH--- 255 Query: 228 RRNKEVMYKIITG----KPSGAISGVQKAENGPIDWSGD-MPVSCSLSRGLQVLLTPVLA 282 N +V+ + TG P + D P + LQ+ L Sbjct: 256 -SNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLN 314 Query: 283 NI 284 +I Sbjct: 315 SI 316 >1U5R-A nrPDB Length = 348 Score = 185 bits (470), Expect = 6e-47, Method: Composition-based stats. Identities = 59/250 (23%), Positives = 98/250 (39%), Gaps = 23/250 (9%) Query: 1 MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFN--NISFLRPVDVQMREFEV 58 + L+ +G G+ V+ R + ++ AIK + ++E Sbjct: 48 FKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRF 107 Query: 59 LKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRD 118 L+KL H N ++ T L+ME+C GS +LE L E E V Sbjct: 108 LQKLRHPNTIQYRGCYLREHT--AWLVMEYC-LGSASDLLEVHKK--PLQEVEIAAVTHG 162 Query: 119 VVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEE 178 + G+ +L + ++HRD+K GNI+ + KL DFG+A + S GT Sbjct: 163 ALQGLAYLHSHNMIHRDVKAGNILLS----EPGLVKLGDFGSASIMAP---ANSFVGTPY 215 Query: 179 YLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKII 238 ++ P++ + +Y VD+WS+G+T A P +Y I Sbjct: 216 WMAPEVILAM-----DEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSA----LYHIA 266 Query: 239 TGKPSGAISG 248 + SG Sbjct: 267 QNESPALQSG 276 >3PVW-A nrPDB Length = 695 Score = 185 bits (469), Expect = 6e-47, Method: Composition-based stats. Identities = 54/287 (18%), Positives = 113/287 (39%), Gaps = 25/287 (8%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNI--SFLRPVDVQMREFEVLKKL---N 63 + + I+G+G V+ R TG ++A+K + + + + E +L + + Sbjct: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 Query: 64 HKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 123 IV + T I++ G L+ L + E++ +++ G+ Sbjct: 251 CPFIVCMSYAFH--TPDKLSFILDLMNGGDLHYHLSQHG---VFSEADMRFYAAEIILGL 305 Query: 124 NHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPD 183 H+ +V+RD+KP NI+ D +++D G A + + S GT Y+ P+ Sbjct: 306 EHMHNRFVVYRDLKPANILL----DEHGHVRISDLGLACDFSKKKPHAS-VGTHGYMAPE 360 Query: 184 MYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNK--EVMYKIITGK 241 + ++ V Y ++ D +S+G + G PFR + +++ + + Sbjct: 361 VLQKGVA-------YDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVEL 413 Query: 242 PSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEAD 288 P ++ G + + + C L RG Q + L+ Sbjct: 414 PDSFSPELRSLLEGLLQRDVNRRLGC-LGRGAQEVKESPFFRSLDWQ 459 >6CKI-A nrPDB Length = 316 Score = 185 bits (469), Expect = 7e-47, Method: Composition-based stats. Identities = 59/238 (24%), Positives = 99/238 (41%), Gaps = 20/238 (8%) Query: 1 MQSTSNHLWLL-SDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVL 59 ++ L D+LG+GA A V + T +A+K+ RE E+L Sbjct: 6 FSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGH-IRSRVFREVEML 64 Query: 60 KKLN-HKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRD 118 + H+N+++ IE L+ E GS+ + + + + E E +V++D Sbjct: 65 YQCQGHRNVLE--LIEFFEEEDRFYLVFEKMRGGSILSHIHKRRH---FNELEASVVVQD 119 Query: 119 VVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELE--------DDEQF 170 V ++ L GI HRD+KP NI+ K+ DFG ++ + Sbjct: 120 VASALDFLHNKGIAHRDLKPENILCEHPNQVSP-VKICDFGLGSGIKLNGDCSPISTPEL 178 Query: 171 VSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPR 228 ++ G+ EY+ P++ E + Y DLWS+GV Y +G PF G Sbjct: 179 LTPCGSAEYMAPEVVEAF---SEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSD 233 >4O2Z-A nrPDB Length = 377 Score = 184 bits (468), Expect = 9e-47, Method: Composition-based stats. Identities = 57/299 (19%), Positives = 109/299 (36%), Gaps = 34/299 (11%) Query: 7 HLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNI-SFLRPVDVQMREFEVLKKLNHK 65 + L ILG GA TG+ +IK ++ + +RE ++++ +H+ Sbjct: 45 SKYTLLKILGMGAYGIACSCLDGDTGEKVSIKKCRDVFRDVEDGKRVLREIDMMRFFHHE 104 Query: 66 NIVKLFAIEEETTTRH-----KVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVV 120 N++ + I + ++ + VL + L ES + ++ Sbjct: 105 NLLNVVNILPPLKREYHSFEDVYVVTPLMDV-DMNVVLR---SRQVLEESHMQYFVYQIL 160 Query: 121 GGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELE-DDEQFVSLYGTEEY 179 G+ +L + HRD+KP N++ I + K+ DFG +R ++ + T Y Sbjct: 161 RGLKYLHSANVAHRDLKPANLVTNISCE----LKIIDFGLSRSVDVPYSELTDYVITRWY 216 Query: 180 LHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIIT 239 P++ Y VD+WS+G F F + + + I Sbjct: 217 RPPELL-------LENTNYSTAVDIWSVGCIFAEMYNRKPVFPGRNTMDQLRMIAQHI-- 267 Query: 240 GKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLL------TPVLANILEADQEKC 292 GKP +I ++A ++ ++P L L L+ + D K Sbjct: 268 GKPPASIVEHREA----LEKLNELPDGSLNIPKLVPGLAGNTEGIDFLSKMWTLDPSKR 322 >5GNK-A nrPDB Length = 297 Score = 184 bits (468), Expect = 1e-46, Method: Composition-based stats. Identities = 58/264 (21%), Positives = 100/264 (37%), Gaps = 20/264 (7%) Query: 13 DILGQGATANVFRGRHKKTGDLF----AIKVFNNISFLRPVDVQMREFEVLKKLNHKNIV 68 +LG GA V++G G+ AIK + + + E V+ +++ ++ Sbjct: 25 KVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVC 84 Query: 69 KLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE 128 +L I +T + LIM+ P G L + E + G L + GMN+L + Sbjct: 85 RLLGICLTSTVQ---LIMQLMPFGCLLDYVREHKDNIG--SQYLLNWCVQIAKGMNYLED 139 Query: 129 NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERA 188 +VHRD+ N++ + K+TDFG A+ L +E+ G + + Sbjct: 140 RRLVHRDLAARNVLVKTPQ----HVKITDFGLAKLLGAEEKEYHAEGGKVP-----IKWM 190 Query: 189 VLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVMYKIITGKPSGAIS 247 L + Y D+WS GVT + T GS P+ + + +P Sbjct: 191 ALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTI 250 Query: 248 GVQK-AENGPIDWSGDMPVSCSLS 270 V + + P L Sbjct: 251 DVYMIMVKCWMIDADSRPKFRELI 274 >4F0G-A nrPDB Length = 287 Score = 184 bits (468), Expect = 1e-46, Method: Composition-based stats. Identities = 66/279 (23%), Positives = 108/279 (38%), Gaps = 29/279 (10%) Query: 12 SDILGQGATANVFRGRHKKTGDLFAIKVFN------NISFLRPVDVQMREFEVLKKLNHK 65 +G+G V +GR K + AIK + RE ++ LNH Sbjct: 24 EKQIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQREVFIMSNLNHP 83 Query: 66 NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 125 NIVKL+ + ++MEF PCG LY L A+ + S L ++ D+ G+ + Sbjct: 84 NIVKLYGLMHNPPR----MVMEFVPCGDLYHRL--LDKAHPIKWSVKLRLMLDIALGIEY 137 Query: 126 LRENG--IVHRDIKPGNIMR-VIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHP 182 ++ IVHRD++ NI + E+ K+ DFG +++ L G +++ P Sbjct: 138 MQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQ--SVHSVSGLLGNFQWMAP 195 Query: 183 DMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKP 242 + ++ Y D +S + Y TG PF + + M + G Sbjct: 196 ETIGAE------EESYTEKADTYSFAMILYTILTGEGPFDEYSYGKIKFINMIR-EEGLR 248 Query: 243 SGAISGVQKAENGPID--WSGD---MPVSCSLSRGLQVL 276 I+ WSGD P + + L L Sbjct: 249 PTIPEDCPPRLRNVIELCWSGDPKKRPHFSYIVKELSEL 287 >6E4F-A nrPDB Length = 290 Score = 184 bits (467), Expect = 1e-46, Method: Composition-based stats. Identities = 58/236 (24%), Positives = 100/236 (42%), Gaps = 30/236 (12%) Query: 10 LLSDILGQGATANVFRGRHKKTGDL-FAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIV 68 LG G V G+ + G AIK+ S D + E +V+ L+H+ +V Sbjct: 34 TFLKELGTGQFGVVKYGKWR--GQYDVAIKMIKEGSMSE--DEFIEEAKVMMNLSHEKLV 89 Query: 69 KLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE 128 +L+ + + R +I E+ G L L E + + L + +DV M +L Sbjct: 90 QLYGVCTKQ--RPIFIITEYMANGCLLNYLREMRHR--FQTQQLLEMCKDVCEAMEYLES 145 Query: 129 NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTE---EYLHPDMY 185 +HRD+ N + + Q V K++DFG +R + DDE + S G++ + P++ Sbjct: 146 KQFLHRDLAARNCLV----NDQGVVKVSDFGLSRYVLDDE-YTSSVGSKFPVRWSPPEVL 200 Query: 186 ERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVMYKIITG 240 K+ + D+W+ GV + + G +P+ F N E I G Sbjct: 201 M--------YSKFSSKSDIWAFGVLMWEIYSLGKMPYERF----TNSETAEHIAQG 244 >1JNK-A nrPDB Length = 423 Score = 184 bits (467), Expect = 1e-46, Method: Composition-based stats. Identities = 63/313 (20%), Positives = 101/313 (32%), Gaps = 36/313 (11%) Query: 3 STSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVF-NNISFLRPVDVQMREFEVLKK 61 T + +G GA V AIK RE ++K Sbjct: 58 FTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKC 117 Query: 62 LNHKNIVKLFAIEEETTT----RHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLR 117 +NHKNI+ L + T + L+ME +L V++ L +L Sbjct: 118 VNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQME-----LDHERMSYLLY 171 Query: 118 DVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTE 177 ++ G+ HL GI+HRD+KP NI+ K+ DFG AR T Sbjct: 172 QMLCGIKHLHSAGIIHRDLKPSNIVV----KSDCTLKILDFGLARTAGTSFMMTPYVVTR 227 Query: 178 EYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKI 237 Y P++ Y VD+WS+G + F + + +V+ ++ Sbjct: 228 YYRAPEVILGM--------GYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQL 279 Query: 238 ITGKPSGA---ISGVQKAENGPIDW----------SGDMPVSCSLSRGLQVLLTPVLANI 284 T P V+ + P ++ +L+ + Sbjct: 280 GTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKM 339 Query: 285 LEADQEKCWGFDQ 297 L D K D Sbjct: 340 LVIDPAKRISVDD 352 >2PSQ-A nrPDB Length = 370 Score = 184 bits (467), Expect = 1e-46, Method: Composition-based stats. Identities = 55/301 (18%), Positives = 101/301 (33%), Gaps = 40/301 (13%) Query: 4 TSNHLWLLSDILGQGATANVFRGR----HKKTGDL---FAIKVFNNISFLRPVDVQMREF 56 L LG+G V K A+K+ + + + + + E Sbjct: 78 FPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEM 137 Query: 57 EVLKKL-NHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPS--------NAYGL 107 E++K + HKNI+ L + +I+E+ G+L L + + Sbjct: 138 EMMKMIGKHKNIINLLGACTQ--DGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRV 195 Query: 108 PESE-----FLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAAR 162 PE + + + GM +L +HRD+ N++ V K+ DFG AR Sbjct: 196 PEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENN----VMKIADFGLAR 251 Query: 163 ELEDDEQFVSLYGTE---EYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GS 218 ++ + + + +++ P+ + Y D+WS GV + T G Sbjct: 252 DINNIDYYKKTTNGRLPVKWMAPEALF--------DRVYTHQSDVWSFGVLMWEIFTLGG 303 Query: 219 LPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGPIDWSGD-MPVSCSLSRGLQVLL 277 P+ K + KP+ + + P L L +L Sbjct: 304 SPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 363 Query: 278 T 278 T Sbjct: 364 T 364 >2GCD-A nrPDB Length = 309 Score = 184 bits (467), Expect = 1e-46, Method: Composition-based stats. Identities = 59/250 (23%), Positives = 98/250 (39%), Gaps = 23/250 (9%) Query: 1 MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFN--NISFLRPVDVQMREFEV 58 + L+ +G G+ V+ R + ++ AIK + ++E Sbjct: 9 FKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRF 68 Query: 59 LKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRD 118 L+KL H N ++ T L+ME+C GS +LE L E E V Sbjct: 69 LQKLRHPNTIQYRGCYLREHT--AWLVMEYC-LGSASDLLEVHKK--PLQEVEIAAVTHG 123 Query: 119 VVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEE 178 + G+ +L + ++HRD+K GNI+ + KL DFG+A + S GT Sbjct: 124 ALQGLAYLHSHNMIHRDVKAGNILLS----EPGLVKLGDFGSASIMAP---ANSFVGTPY 176 Query: 179 YLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKII 238 ++ P++ + +Y VD+WS+G+T A P +Y I Sbjct: 177 WMAPEVILAM-----DEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSA----LYHIA 227 Query: 239 TGKPSGAISG 248 + SG Sbjct: 228 QNESPALQSG 237 >5O2B-A nrPDB Length = 285 Score = 184 bits (467), Expect = 1e-46, Method: Composition-based stats. Identities = 58/244 (23%), Positives = 97/244 (39%), Gaps = 24/244 (9%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLR-PVDVQMREFEVLKKLNHKNIVKLFAI 73 LG+GA V++G +T A + + E E+LK L H NIV+ + Sbjct: 24 LGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDS 83 Query: 74 EEE--TTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN-- 129 E + VL+ E G+L T L+ + R ++ G+ L Sbjct: 84 WESILKGKKCIVLVTELMTSGTLKTYLKRFK---VMKPKVLRSWCRQILKGLQFLHTRTP 140 Query: 130 GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAV 189 I+HRD+K NI K+ D G A + S+ GT E++ P+MYE Sbjct: 141 PIIHRDLKCDNIFIT---GPTGSVKIGDLGLATLMR-TSFAKSVIGTPEFMAPEMYE--- 193 Query: 190 LRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGV 249 + Y +VD+++ G+ AT P+ + ++ K+ +G + + V Sbjct: 194 ------EHYDESVDVYAFGMCMLEMATSEYPY---SECQNAAQIYRKVTSGIKPASFNKV 244 Query: 250 QKAE 253 E Sbjct: 245 TDPE 248 >4XI2-A nrPDB Length = 446 Score = 184 bits (467), Expect = 1e-46, Method: Composition-based stats. Identities = 60/278 (21%), Positives = 110/278 (39%), Gaps = 35/278 (12%) Query: 10 LLSDILGQGATANVFRGRHKKTGDL-FAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIV 68 LG G V G+ + G AIK+ S D + E +V+ L+H+ +V Sbjct: 190 TFLKELGTGQFGVVKYGKWR--GQYDVAIKMIREGSMSE--DEFIEEAKVMMNLSHEKLV 245 Query: 69 KLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE 128 +L+ + + R +I E+ G L L E + + L + +DV M +L Sbjct: 246 QLYGVCTKQ--RPIFIITEYMANGCLLNYLREMRHR--FQTQQLLEMCKDVCEAMEYLES 301 Query: 129 NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTE---EYLHPDMY 185 +HRD+ N + + Q V K++DFG +R + DDE + S G++ + P++ Sbjct: 302 KQFLHRDLAARNCLV----NDQGVVKVSDFGLSRYVLDDE-YTSSVGSKFPVRWSPPEVL 356 Query: 186 ERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVMYKIITGKPSG 244 K+ + D+W+ GV + + G +P+ F N E I G Sbjct: 357 M--------YSKFSSKSDIWAFGVLMWEIYSLGKMPYERF----TNSETAEHIAQGLRLY 404 Query: 245 AISGVQKAE-----NGPIDWSGDMPVSCSLSRGLQVLL 277 + + + + + P L + ++ Sbjct: 405 RPHLASERVYTIMYSCWHEKADERPSFKILLSNILDVM 442 >5HLW-A nrPDB Length = 299 Score = 184 bits (466), Expect = 1e-46, Method: Composition-based stats. Identities = 49/216 (22%), Positives = 89/216 (41%), Gaps = 14/216 (6%) Query: 11 LSDILGQGATANVFRGR---HKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNI 67 ++++G+G V+ G + A+K N I+ + V + E ++K +H N+ Sbjct: 24 FNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNV 83 Query: 68 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 127 + L I + V ++ + G L + ++ + + + V GM +L Sbjct: 84 LSLLGICLRSEGSPLV-VLPYMKHGDLRNFIRNETHNPTV--KDLIGFGLQVAKGMKYLA 140 Query: 128 ENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYER 187 VHRD+ N M D + K+ DFG AR++ D E + T L + Sbjct: 141 SKKFVHRDLAARNCML----DEKFTVKVADFGLARDMHDKEYYSVHNKTGAKLP---VKW 193 Query: 188 AVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFR 222 L +K+ D+WS GV + T G+ P+ Sbjct: 194 MALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYP 229 >4OTD-A nrPDB Length = 341 Score = 184 bits (466), Expect = 2e-46, Method: Composition-based stats. Identities = 78/379 (20%), Positives = 135/379 (35%), Gaps = 66/379 (17%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNN--ISFLRPVDVQMREFEVLKKL---N 63 + +LG+G V + +G+LFAIK I V+ M E +L + Sbjct: 14 FKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTSAG 73 Query: 64 HKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 123 H +V LF + T H +ME+ G L + + E + VV G+ Sbjct: 74 HPFLVNLFGCFQ--TPEHVCFVMEYSAGGDLMLHIH----SDVFSEPRAIFYSACVVLGL 127 Query: 124 NHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARE-LEDDEQFVSLYGTEEYLHP 182 L E+ IV+R + + D + K+ DFG +E + ++ + GT E+L P Sbjct: 128 QFLHEHKIVYR----DLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAP 183 Query: 183 DMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKP 242 ++ Y VD W +GV Y G PF +EV I+ Sbjct: 184 EVL--------TDTSYTRAVDWWGLGVLLYEMLVGESPFPG----DDEEEVFDSIV---- 227 Query: 243 SGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFAET 302 N + + R L ++ +L + E+ G + + Sbjct: 228 -----------NDEVRY----------PRFLSAEAIGIMRRLLRRNPERRLGSSE--RDA 264 Query: 303 SDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLVLE 362 D+ + + + A ++ T + +T + + ++E E L Sbjct: 265 EDVKKQPFFRTLGWEALLARRLPPPFVPTLSG-------RTDVSNFDEEFTGEAP--TLS 315 Query: 363 PGRLAQHFPKTTEENPIFV 381 P R A+ P T E F+ Sbjct: 316 PPRDAR--PLTAAEQAAFL 332 >5O2C-A nrPDB Length = 380 Score = 183 bits (465), Expect = 2e-46, Method: Composition-based stats. Identities = 58/244 (23%), Positives = 97/244 (39%), Gaps = 24/244 (9%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLR-PVDVQMREFEVLKKLNHKNIVKLFAI 73 LG+GA V++G +T A + + E E+LK L H NIV+ + Sbjct: 33 LGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDS 92 Query: 74 EEE--TTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN-- 129 E + VL+ E G+L T L+ + R ++ G+ L Sbjct: 93 WESILKGKKCIVLVTELMTSGTLKTYLKRFK---VMKPKVLRSWCRQILKGLQFLHTRTP 149 Query: 130 GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAV 189 I+HRD+K NI K+ D G A + S+ GT E++ P+MYE Sbjct: 150 PIIHRDLKCDNIFIT---GPTGSVKIGDLGLATLMR-TSFAKSVIGTPEFMAPEMYE--- 202 Query: 190 LRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGV 249 + Y +VD+++ G+ AT P+ + ++ K+ +G + + V Sbjct: 203 ------EHYDESVDVYAFGMCMLEMATSEYPY---SECQNAAQIYRKVTSGIKPASFNKV 253 Query: 250 QKAE 253 E Sbjct: 254 TDPE 257 >4Y93-A nrPDB Length = 446 Score = 183 bits (465), Expect = 2e-46, Method: Composition-based stats. Identities = 59/274 (21%), Positives = 112/274 (40%), Gaps = 27/274 (9%) Query: 10 LLSDILGQGATANVFRGRHKKTGDL-FAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIV 68 LG G V G+ + G AIK+ S D + E +V+ L+H+ +V Sbjct: 191 TFLKELGTGQFGVVKYGKWR--GQYDVAIKMIKEGSMSE--DEFIEEAKVMMNLSHEKLV 246 Query: 69 KLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE 128 +L+ + + R +I E+ G L L E + + L + +DV M +L Sbjct: 247 QLYGVCTKQ--RPIFIITEYMANGCLLNYLREMRHR--FQTQQLLEMCKDVCEAMEYLES 302 Query: 129 NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTE---EYLHPDMY 185 +HRD+ N + + Q V K++DFG R + DDE + S G++ ++ P++ Sbjct: 303 KQFLHRDLAARNCLV----NDQGVVKVSDFGMTRYVLDDE-YTSSTGSKFPVKWASPEVL 357 Query: 186 ERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVMYKIITGKPSG 244 K+ + D+W+ GV + + G +P+ F + + + +P Sbjct: 358 M--------YSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLPRPHL 409 Query: 245 AISGV-QKAENGPIDWSGDMPVSCSLSRGLQVLL 277 A V + + + + P L + ++ Sbjct: 410 ASERVYAIMYSCWHEKADERPTFKILLSNILDVM 443 >4K33-A nrPDB Length = 325 Score = 183 bits (465), Expect = 2e-46, Method: Composition-based stats. Identities = 55/300 (18%), Positives = 99/300 (33%), Gaps = 40/300 (13%) Query: 5 SNHLWLLSDILGQGATANVFRGRHKKTGD-------LFAIKVFNNISFLRPVDVQMREFE 57 S L LG+GA V A+K+ + + + + + E E Sbjct: 34 SRARLTLGKPLGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEME 93 Query: 58 VLKKL-NHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNA------------ 104 ++K + HKNI+ L + +++E+ G+L L Sbjct: 94 MMKMIGKHKNIINLLGACTQGGP--LYVLVEYAAKGNLREFLRARRPPGLDYSFDTSKPP 151 Query: 105 -YGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARE 163 L + + V GM +L +HRD+ N++ V K+ DFG AR+ Sbjct: 152 EEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDN----VMKIADFGLARD 207 Query: 164 LEDDEQFVSLYGTE---EYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSL 219 + + + + +++ P+ + Y D+WS GV + T G Sbjct: 208 VHNLDYYKETTNGRLPVKWMAPEALF--------DRVYTHQSDVWSFGVLLWEIFTLGGS 259 Query: 220 PFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGPIDWSGD-MPVSCSLSRGLQVLLT 278 P+ K + KP+ + + P L L +LT Sbjct: 260 PYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLT 319 >3LZB-A nrPDB Length = 327 Score = 183 bits (464), Expect = 3e-46, Method: Composition-based stats. Identities = 58/264 (21%), Positives = 98/264 (37%), Gaps = 20/264 (7%) Query: 13 DILGQGATANVFRGRHKKTGDLF----AIKVFNNISFLRPVDVQMREFEVLKKLNHKNIV 68 +LG GA V++G G+ AIK + + + E V+ +++ ++ Sbjct: 21 KVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVC 80 Query: 69 KLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE 128 +L I +T + LI + P G L + E + G L + GMN+L + Sbjct: 81 RLLGICLTSTVQ---LITQLMPFGCLLDYVREHKDNIG--SQYLLNWCVQIAKGMNYLED 135 Query: 129 NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERA 188 +VHRD+ N++ + K+TDFG A+ L +E+ G + + Sbjct: 136 RRLVHRDLAARNVLVKTPQ----HVKITDFGLAKLLGAEEKEYHAEGGKVP-----IKWM 186 Query: 189 VLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVMYKIITGKPSGAIS 247 L + Y D+WS GVT + T GS P+ + + +P Sbjct: 187 ALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTI 246 Query: 248 GVQKAENGPIDWSGD-MPVSCSLS 270 V D P L Sbjct: 247 DVYMIMRKCWMIDADSRPKFRELI 270 >3FI2-A nrPDB Length = 353 Score = 183 bits (464), Expect = 3e-46, Method: Composition-based stats. Identities = 63/313 (20%), Positives = 101/313 (32%), Gaps = 36/313 (11%) Query: 3 STSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVF-NNISFLRPVDVQMREFEVLKK 61 T + +G GA V AIK RE ++K Sbjct: 20 FTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKC 79 Query: 62 LNHKNIVKLFAIEEETTT----RHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLR 117 +NHKNI+ L + T + L+ME +L V++ L +L Sbjct: 80 VNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQME-----LDHERMSYLLY 133 Query: 118 DVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTE 177 ++ G+ HL GI+HRD+KP NI+ K+ DFG AR T Sbjct: 134 QMLCGIKHLHSAGIIHRDLKPSNIVV----KSDCTLKILDFGLARTAGTSFMMTPYVVTR 189 Query: 178 EYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKI 237 Y P++ Y VD+WS+G + F + + +V+ ++ Sbjct: 190 YYRAPEVILGM--------GYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQL 241 Query: 238 ITGKPSGA---ISGVQKAENGPIDW----------SGDMPVSCSLSRGLQVLLTPVLANI 284 T P V+ + P ++ +L+ + Sbjct: 242 GTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKM 301 Query: 285 LEADQEKCWGFDQ 297 L D K D Sbjct: 302 LVIDPAKRISVDD 314 >3PG1-A nrPDB Length = 362 Score = 183 bits (464), Expect = 3e-46, Method: Composition-based stats. Identities = 64/307 (20%), Positives = 113/307 (36%), Gaps = 31/307 (10%) Query: 7 HLWLLSDILGQGATANVFRGRHKKTGDLFAIK-VFNNISFLRPVDVQ---------MREF 56 + + + G+ V G + G AIK VFN +S R V++ +RE Sbjct: 22 SPYTVQRFISSGSYGAVCAGVDSE-GIPVAIKRVFNTVSDGRTVNILSDSFLCKRVLREI 80 Query: 57 EVLKKLNHKNIVKLFAIE---EETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFL 113 +L +H NI+ L I EE L+ E L V+ + + Sbjct: 81 RLLNHFHHPNILGLRDIFVHFEEPAMHKLYLVTELMR-TDLAQVIHDQR--IVISPQHIQ 137 Query: 114 IVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSL 173 + ++ G++ L E G+VHRD+ PGNI+ D + DF ARE D Sbjct: 138 YFMYHILLGLHVLHEAGVVHRDLHPGNILLADNND----ITICDFNLAREDTADANKTHY 193 Query: 174 YGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEV 233 Y P++ K + VD+WS G FR + ++ Sbjct: 194 VTHRWYRAPELVM-------QFKGFTKLVDMWSAGCVMAEMFNRKALFRGSTFYNQLNKI 246 Query: 234 MYKIITGKPSGAISGVQKAENGPIDWS-GDMPVS--CSLSRGLQVLLTPVLANILEADQE 290 + + T K + + + S ++P ++ + ++A +LE + + Sbjct: 247 VEVVGTPKIEDVVMFSSPSARDYLRNSLSNVPARAWTAVVPTADPVALDLIAKMLEFNPQ 306 Query: 291 KCWGFDQ 297 + +Q Sbjct: 307 RRISTEQ 313 >1FVR-A nrPDB Length = 327 Score = 182 bits (463), Expect = 4e-46, Method: Composition-based stats. Identities = 72/302 (23%), Positives = 108/302 (35%), Gaps = 44/302 (14%) Query: 11 LSDILGQGATANVFRGRHKKTGDLF--AIKVFNNISFLRPVDVQMREFEVLKKL-NHKNI 67 D++G+G V + R KK G AIK + E EVL KL +H NI Sbjct: 29 FQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNI 88 Query: 68 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEE-------------PSNAYGLPESEFLI 114 + L E + L +E+ P G+L L + S A L + L Sbjct: 89 INLLGACE--HRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLH 146 Query: 115 VLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLY 174 DV GM++L + +HRD+ NI+ V K+ DFG +R E + Sbjct: 147 FAADVARGMDYLSQKQFIHRDLAARNILVG----ENYVAKIADFGLSRGQEVYVKKTMGR 202 Query: 175 GTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEV 233 ++ + +V Y D+WS GV + + G P+ E+ Sbjct: 203 LPVRWMAIESLNYSV--------YTTNSDVWSYGVLLWEIVSLGGTPYCG----MTCAEL 250 Query: 234 MYKIITG----KPSGAISGVQKAENGPIDWSG-DMPVSC----SLSRGLQVLLTPVLANI 284 K+ G KP V + P SL+R L+ T V + Sbjct: 251 YEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEERKTYVNTTL 310 Query: 285 LE 286 E Sbjct: 311 YE 312 >3AOX-A nrPDB Length = 344 Score = 182 bits (462), Expect = 4e-46, Method: Composition-based stats. Identities = 62/289 (21%), Positives = 111/289 (38%), Gaps = 33/289 (11%) Query: 1 MQSTSNHLWLLSDILGQGATANVFRGR-----HKKTGDLFAIKVFNNISFLRPVDVQMRE 55 ++ L LG GA V+ G+ + + A+K + + + E Sbjct: 41 LKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLME 100 Query: 56 FEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEE----PSNAYGLPESE 111 ++ K NH+NIV+ + ++ R +++E G L + L E PS L + Sbjct: 101 ALIISKFNHQNIVRCIGVSLQSLPR--FILLELMAGGDLKSFLRETRPRPSQPSSLAMLD 158 Query: 112 FLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFV 171 L V RD+ G +L EN +HRDI N + G+ V K+ DFG AR++ + Sbjct: 159 LLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGR-VAKIGDFGMARDIYRASYYR 217 Query: 172 SLYGT---EEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGP 227 +++ P+ + + + + D WS GV + + G +P+ Sbjct: 218 KGGCAMLPVKWMPPEAFMEGI--------FTSKTDTWSFGVLLWEIFSLGYMPYP----S 265 Query: 228 RRNKEVMYKIITG---KPSGAISGVQKAE--NGPIDWSGDMPVSCSLSR 271 + N+EV+ + +G P G D P + Sbjct: 266 KSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILE 314 >1U54-B nrPDB Length = 291 Score = 182 bits (461), Expect = 6e-46, Method: Composition-based stats. Identities = 57/290 (19%), Positives = 106/290 (36%), Gaps = 33/290 (11%) Query: 11 LSDILGQGATANVFRGRHK-KTGDLF--AIKVFNNISFLRP--VDVQMREFEVLKKLNHK 65 L + LG G+ V RG +G A+K +P +D +RE + L+H+ Sbjct: 22 LLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHR 81 Query: 66 NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 125 N+++L+ + + ++ E P GSL L + + L V GM + Sbjct: 82 NLIRLYGVVLTPPMK---MVTELAPLGSLLDRLRKHQGHFLL--GTLSRYAVQVAEGMGY 136 Query: 126 LRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEE----YLH 181 L +HRD+ N++ + + K+ DFG R L ++ + + + Sbjct: 137 LESKRFIHRDLAARNLLLAT----RDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCA 192 Query: 182 PDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVMYKI-IT 239 P+ + + + D W GVT + T G P+ G ++++KI Sbjct: 193 PESLK--------TRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNG----SQILHKIDKE 240 Query: 240 GKPSGAISGVQKAE-NGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEAD 288 G+ + N + P L+ L + A+ Sbjct: 241 GERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRDFLLEAQPTDMRAE 290 >3ALO-A nrPDB Length = 327 Score = 182 bits (461), Expect = 6e-46, Method: Composition-based stats. Identities = 65/262 (24%), Positives = 115/262 (43%), Gaps = 28/262 (10%) Query: 3 STSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEV-LKK 61 T+ L L + +G+GA +V + HK +G + A+K + + + + +V ++ Sbjct: 19 FTAEDLKDLGE-IGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRS 77 Query: 62 LNHKNIVKLFAIEEETTTRHKVLIMEFCP------CGSLYTVLEEPSNAYGLPESEFLIV 115 + IV+ + + ME +Y+VL++ +PE + Sbjct: 78 SDCPYIVQFYGALFREGDC--WICMELMSTSFDKFYKYVYSVLDD-----VIPEEILGKI 130 Query: 116 LRDVVGGMNHLREN-GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLY 174 V +NHL+EN I+HRDIKP NI+ D KL DFG + +L D Sbjct: 131 TLATVKALNHLKENLKIIHRDIKPSNILL----DRSGNIKLCDFGISGQLVDSIAKTRDA 186 Query: 175 GTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVM 234 G Y+ P+ + + R + Y D+WS+G+T Y ATG P+ + + + Sbjct: 187 GCRPYMAPERIDPSASR----QGYDVRSDVWSLGITLYELATGRFPYPKWNSV---FDQL 239 Query: 235 YKIITGKPSGAISGVQKAENGP 256 +++ G P +S ++ E P Sbjct: 240 TQVVKGDPP-QLSNSEEREFSP 260 >3MIA-A nrPDB Length = 351 Score = 182 bits (461), Expect = 6e-46, Method: Composition-based stats. Identities = 59/228 (25%), Positives = 94/228 (41%), Gaps = 32/228 (14%) Query: 7 HLWLLSDILGQGATANVFRGRHKKTGDLFAI-KVFNNISFLRPVDVQMREFEVLKKLNHK 65 + +GQG VF+ RH+KTG A+ KV +RE ++L+ L H+ Sbjct: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHE 76 Query: 66 NIVKLFAIEEETTTRH------KVLIMEFCPC---GSLYTVLEEPSNAYGLPESEFLIVL 116 N+V L I + + L+ +FC G L VL + SE V+ Sbjct: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK------FTLSEIKRVM 130 Query: 117 RDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAAREL-----EDDEQFV 171 + ++ G+ ++ N I+HRD+K N++ V KL DFG AR ++ Sbjct: 131 QMLLNGLYYIHRNKILHRDMKAANVLIT----RDGVLKLADFGLARAFSLAKNSQPNRYT 186 Query: 172 SLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSL 219 + T Y P++ ++ YG +DLW G T S Sbjct: 187 NRVVTLWYRPPELLLG-------ERDYGPPIDLWGAGCIMAEMWTRSP 227 >3E3P-A nrPDB Length = 360 Score = 181 bits (460), Expect = 8e-46, Method: Composition-based stats. Identities = 59/263 (22%), Positives = 105/263 (39%), Gaps = 29/263 (11%) Query: 7 HLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKL---N 63 + + + GQG V G+ K TG AIK ++ + RE ++++ L + Sbjct: 23 DRFQVERMAGQGTFGTVQLGKEKSTGMSVAIKKV-----IQDPRFRNRELQIMQDLAVLH 77 Query: 64 HKNIVKLFAIEE-----ETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLI-VLR 117 H NIV+L + + + ++ME+ P +L+ P + L Sbjct: 78 HPNIVQLQSYFYTLGERDRRDIYLNVVMEYVP-DTLHRCCRNYYRRQVAPPPILIKVFLF 136 Query: 118 DVVGGMNHLR--ENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYG 175 ++ + L + HRDIKP N++ + KL DFG+A++L E V+ Sbjct: 137 QLIRSIGCLHLPSVNVCHRDIKPHNVLV---NEADGTLKLCDFGSAKKLSPSEPNVAYIC 193 Query: 176 TEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMY 235 + Y P++ + Y VD+WS+G F G FR + E++ Sbjct: 194 SRYYRAPELIFG-------NQHYTTAVDIWSVGCIFAEMMLGEPIFRGDNSAGQLHEIVR 246 Query: 236 KIITGKPSGAISGVQKAENGPID 258 + G PS + + +D Sbjct: 247 --VLGCPSREVLRKLNPSHTDVD 267 >1BYG-A nrPDB Length = 278 Score = 180 bits (458), Expect = 1e-45, Method: Composition-based stats. Identities = 60/273 (21%), Positives = 100/273 (36%), Gaps = 23/273 (8%) Query: 11 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKL 70 L +G+G +V G ++ G+ A+K N + + E V+ +L H N+V+L Sbjct: 25 LLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDAT---AQAFLAEASVMTQLRHSNLVQL 79 Query: 71 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 130 + E ++ E+ GSL L + L L DV M +L N Sbjct: 80 LGVIVEE-KGGLYIVTEYMAKGSLVDYLRSRGRSV-LGGDCLLKFSLDVCEAMEYLEGNN 137 Query: 131 IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVL 190 VHRD+ N++ V K++DFG +E + L ++ P+ Sbjct: 138 FVHRDLAARNVLVSEDN----VAKVSDFGLTKEASSTQDTGKL--PVKWTAPEALR---- 187 Query: 191 RKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVMYKIITGKPSGAISGV 249 +KK+ D+WS G+ + + G +P+ V P G V Sbjct: 188 ----EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAV 243 Query: 250 QKAENGPIDWSGDM-PVSCSLSRGLQVLLTPVL 281 + M P L L+ + T L Sbjct: 244 YEVMKNCWHLDAAMRPSFLQLREQLEHIKTHEL 276 >5EG3-A nrPDB Length = 334 Score = 180 bits (458), Expect = 2e-45, Method: Composition-based stats. Identities = 56/301 (18%), Positives = 101/301 (33%), Gaps = 40/301 (13%) Query: 4 TSNHLWLLSDILGQGATANVFRGR----HKKTGDL---FAIKVFNNISFLRPVDVQMREF 56 L LG+GA V K A+K+ + + + + + E Sbjct: 32 FPRDKLTLGKPLGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEM 91 Query: 57 EVLKKL-NHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPS--------NAYGL 107 E++K + HKNI+ L + +I+ + G+L L + + Sbjct: 92 EMMKMIGKHKNIINLLGACTQ--DGPLYVIVAYASKGNLREYLRARRPPGMELSPDINRV 149 Query: 108 PESE-----FLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAAR 162 PE + + + GM +L +HRD+ N++ V K+ DFG AR Sbjct: 150 PEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENN----VMKIADFGLAR 205 Query: 163 ELEDDEQFVSLYGTE---EYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GS 218 ++ + + F +++ P+ + Y D+WS GV + T G Sbjct: 206 DINNIDFFKETTNGRLPVKWMAPEALF--------DRVYTHQSDVWSFGVLMWEIFTLGG 257 Query: 219 LPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGPIDWSGD-MPVSCSLSRGLQVLL 277 P+ K + KP+ + + P L L +L Sbjct: 258 SPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 317 Query: 278 T 278 T Sbjct: 318 T 318 >5UNP-A nrPDB Length = 369 Score = 180 bits (457), Expect = 2e-45, Method: Composition-based stats. Identities = 64/308 (20%), Positives = 119/308 (38%), Gaps = 42/308 (13%) Query: 7 HLWLLSDILGQGATANVFRGR-HKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHK 65 + + LG+G V + H++ G A+K+ N+ + + E VL+K+N K Sbjct: 34 ERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVE--KYKEAARLEINVLEKINEK 91 Query: 66 N------IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDV 119 + V++F + H + E S + L++ N P + + + Sbjct: 92 DPDNKNLCVQMFDWFDY--HGHMCISFELL-GLSTFDFLKDN-NYLPYPIHQVRHMAFQL 147 Query: 120 VGGMNHLRENGIVHRDIKPGNIMRVIGE-----------DGQSV----YKLTDFGAAREL 164 + L +N + H D+KP NI+ V + D +SV ++ DFG+A Sbjct: 148 CQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATF- 206 Query: 165 EDDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPF 224 D E ++ T Y P++ + D+WSIG + G F+ Sbjct: 207 -DHEHHSTIVSTRHYRAPEVILEL--------GWSQPCDVWSIGCIIFEYYVGFTLFQTH 257 Query: 225 EGPRRNKEVMYKIITGKPSGAISGVQKAE---NGPIDWSGDMPVSCSLSRGLQVLLTPVL 281 + R + +M +I+ PS I +K + G +DW + + + L + Sbjct: 258 DN-REHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLT 316 Query: 282 ANILEADQ 289 + E Q Sbjct: 317 SEAEEHHQ 324 >3C1X-A nrPDB Length = 373 Score = 180 bits (457), Expect = 2e-45, Method: Composition-based stats. Identities = 49/216 (22%), Positives = 87/216 (40%), Gaps = 14/216 (6%) Query: 11 LSDILGQGATANVFRGR---HKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNI 67 ++++G+G V+ G + A+K N I+ + V + E ++K +H N+ Sbjct: 93 FNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNV 152 Query: 68 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 127 + L I + V ++ + G L + ++ + + + V GM L Sbjct: 153 LSLLGICLRSEGSPLV-VLPYMKHGDLRNFIRNETHNPTV--KDLIGFGLQVAKGMKFLA 209 Query: 128 ENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYER 187 VHRD+ N M D + K+ DFG AR++ D E T L + Sbjct: 210 SKKFVHRDLAARNCML----DEKFTVKVADFGLARDMYDKEFDSVHNKTGAKLP---VKW 262 Query: 188 AVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFR 222 L +K+ D+WS GV + T G+ P+ Sbjct: 263 MALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYP 298 >4C0T-A nrPDB Length = 974 Score = 179 bits (454), Expect = 4e-45, Method: Composition-based stats. Identities = 55/238 (23%), Positives = 106/238 (44%), Gaps = 30/238 (12%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMR--EFEVLKKLNHK- 65 + LG+G+ + V K TG +A+KV + ++ V+ E L +L+++ Sbjct: 268 FKFGKELGEGSYSTVILATDKITGKQYAVKVLDKRHIIKEKKVKYVNIEKHALNRLSNRL 327 Query: 66 NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 125 ++ L+ ++ + ++++ G L T+++ + L E ++ + + Sbjct: 328 GVISLYFTFQDKDS--LYFVLDYASNGELLTLIKRYN---TLNEECTRHFGAQILDAIKY 382 Query: 126 LRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELED----------DEQFVSLYG 175 + +NG++HRD+KP NI+ D + ++TDFG AR LE D + S G Sbjct: 383 MHDNGVIHRDLKPENILL----DDKMRIQITDFGTARLLEKKNDESEEYPVDVRAKSFVG 438 Query: 176 TEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEV 233 T EY+ P++ E K G D+W+ G Y G PF+ +++ Sbjct: 439 TAEYVSPELLE--------NKYCGKPGDVWAFGCIIYQMIAGKPPFKATNEYLTFQKI 488 >1AD5-A nrPDB Length = 438 Score = 179 bits (454), Expect = 4e-45, Method: Composition-based stats. Identities = 56/279 (20%), Positives = 93/279 (33%), Gaps = 29/279 (10%) Query: 4 TSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLN 63 L LG G V+ + K A+K S V+ + E V+K L Sbjct: 179 IPRESLKLEKKLGAGQFGEVWMATYNKHTK-VAVKTMKPGSM--SVEAFLAEANVMKTLQ 235 Query: 64 HKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 123 H +VKL A+ T +I EF GSL L+ + P + + + GM Sbjct: 236 HDKLVKLHAVV---TKEPIYIITEFMAKGSLLDFLKSDEGSKQ-PLPKLIDFSAQIAEGM 291 Query: 124 NHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPD 183 + + +HRD++ NI+ V K+ DFG AR V ++ P+ Sbjct: 292 AFIEQRNYIHRDLRAANILVS----ASLVCKIADFGLAR--------VGAKFPIKWTAPE 339 Query: 184 MYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVMYKIITGKP 242 + + D+WS G+ T G +P+ P + + +P Sbjct: 340 AI--------NFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRP 391 Query: 243 SGAISGVQK-AENGPIDWSGDMPVSCSLSRGLQVLLTPV 280 + + + P + L T Sbjct: 392 ENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTAT 430 >3LM0-A nrPDB Length = 327 Score = 179 bits (453), Expect = 6e-45, Method: Composition-based stats. Identities = 58/235 (24%), Positives = 107/235 (45%), Gaps = 14/235 (5%) Query: 1 MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ-MREFEVL 59 M++ +N L S LG+G A V + K TG +A K + + + E VL Sbjct: 23 MENFNNFYILTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVL 82 Query: 60 KKLNH-KNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRD 118 + ++ L + E T+ +LI+E+ G +++ L P A + E++ + +++ Sbjct: 83 ELAKSCPRVINLHEVYENTS--EIILILEYAAGGEIFS-LCLPELAEMVSENDVIRLIKQ 139 Query: 119 VVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEE 178 ++ G+ +L +N IVH D+KP NI+ K+ DFG +R++ + + GT E Sbjct: 140 ILEGVYYLHQNNIVHLDLKPQNILLSSIY-PLGDIKIVDFGMSRKIGHACELREIMGTPE 198 Query: 179 YLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEV 233 YL P++ + D+W+IG+ Y T + PF + + Sbjct: 199 YLAPEIL--------NYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNI 245 >2I6L-A nrPDB Length = 320 Score = 178 bits (452), Expect = 7e-45, Method: Composition-based stats. Identities = 55/253 (21%), Positives = 95/253 (37%), Gaps = 36/253 (14%) Query: 6 NHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHK 65 ++ LG G VF AIK + + V +RE +++++L+H Sbjct: 10 GSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVL-TDPQSVKHALREIKIIRRLDHD 68 Query: 66 NIVKLFAIEEETTTR------------HKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFL 113 NIVK+F I + ++ ++ E+ L VLE+ L E Sbjct: 69 NIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYME-TDLANVLEQG----PLLEEHAR 123 Query: 114 IVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSL 173 + + ++ G+ ++ ++HRD+KP N+ + V K+ DFG AR ++ Sbjct: 124 LFMYQLLRGLKYIHSANVLHRDLKPANLFINTED---LVLKIGDFGLARIMDPHYSHKGH 180 Query: 174 YG----TEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRR 229 T+ Y P + Y +D+W+ G F TG F Sbjct: 181 LSEGLVTKWYRSPRLLLSP-------NNYTKAIDMWAAGCIFAEMLTGKTLFAGAHE--- 230 Query: 230 NKEVMYKIITGKP 242 E M I+ P Sbjct: 231 -LEQMQLILESIP 242 >4LRM-A nrPDB Length = 334 Score = 178 bits (451), Expect = 1e-44, Method: Composition-based stats. Identities = 57/267 (21%), Positives = 99/267 (37%), Gaps = 23/267 (8%) Query: 13 DILGQGATANVFRGRHKKTGDLF----AIKVFNNISFLRPVDVQMREFEVLKKLNHK--- 65 +LG GA V++G G+ AIK + + + E V+ +++ Sbjct: 25 KVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNP 84 Query: 66 NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 125 ++ +L I +T + LI + P G L + E + G L + GMN+ Sbjct: 85 HVCRLLGICLTSTVQ---LITQLMPFGCLLDYVREHKDNIG--SQYLLNWCVQIAKGMNY 139 Query: 126 LRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMY 185 L + +VHRD+ N++ + K+TDFG A+ L +E+ G + Sbjct: 140 LEDRRLVHRDLAARNVLVKTPQ----HVKITDFGLAKLLGAEEKEYHAEGGKVP-----I 190 Query: 186 ERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVMYKIITGKPSG 244 + L + Y D+WS GVT + T GS P+ + + +P Sbjct: 191 KWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPI 250 Query: 245 AISGVQK-AENGPIDWSGDMPVSCSLS 270 V + + P L Sbjct: 251 CTIDVYMIMVKCWMIDADSRPKFRELI 277 >1K9A-A nrPDB Length = 450 Score = 177 bits (450), Expect = 1e-44, Method: Composition-based stats. Identities = 60/273 (21%), Positives = 101/273 (36%), Gaps = 23/273 (8%) Query: 11 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKL 70 L +G+G +V G ++ G+ A+K N + + E V+ +L H N+V+L Sbjct: 197 LLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDAT---AQAFLAEASVMTQLRHSNLVQL 251 Query: 71 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 130 + E ++ E+ GSL L + L L DV M +L N Sbjct: 252 LGVIVEE-KGGLYIVTEYMAKGSLVDYLRSRGRSV-LGGDCLLKFSLDVCEAMEYLEGNN 309 Query: 131 IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVL 190 VHRD+ N++ V K++DFG +E + L ++ P+ Sbjct: 310 FVHRDLAARNVLVSEDN----VAKVSDFGLTKEASSTQDTGKL--PVKWTAPEALR---- 359 Query: 191 RKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVMYKIITGKPSGAISGV 249 +KK+ D+WS G+ + + G +P+ V P G V Sbjct: 360 ----EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAV 415 Query: 250 QK-AENGPIDWSGDMPVSCSLSRGLQVLLTPVL 281 +N + P L L+ + T L Sbjct: 416 YDVMKNCWHLDAATRPTFLQLREQLEHIRTHEL 448 >4CRS-A nrPDB Length = 341 Score = 177 bits (450), Expect = 1e-44, Method: Composition-based stats. Identities = 54/221 (24%), Positives = 89/221 (40%), Gaps = 24/221 (10%) Query: 14 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDV-----QMREFEVLKKLNHKNIV 68 +L +G V +K T ++FAIK + +V + R FE + + H +V Sbjct: 19 VLLRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLV 78 Query: 69 KLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE 128 LFA + T H +ME+ G L + E + VV G+ +L E Sbjct: 79 NLFACFQ--TKEHVCFVMEYAAGGDLMMHIH----TDVFSEPRAVFYAACVVLGLQYLHE 132 Query: 129 NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARE-LEDDEQFVSLYGTEEYLHPDMYER 187 + IV+R + + D + K+ DFG +E + ++ + GT E+L P++ Sbjct: 133 HKIVYR----DLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVL-- 186 Query: 188 AVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPR 228 + Y VD W +GV Y G PF + Sbjct: 187 ------TETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEE 221 >5HVK-A nrPDB Length = 315 Score = 177 bits (449), Expect = 2e-44, Method: Composition-based stats. Identities = 42/219 (19%), Positives = 93/219 (42%), Gaps = 32/219 (14%) Query: 12 SDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLF 71 ++LG+G + H++TG++ +K ++E +V++ L H N++K Sbjct: 19 GEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQR-TFLKEVKVMRCLEHPNVLKFI 77 Query: 72 AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGI 131 + + + I E+ G+L +++ + Y P S+ + +D+ GM +L I Sbjct: 78 GVLYK--DKRLNFITEYIKGGTLRGIIKSMDSQY--PWSQRVSFAKDIASGMAYLHSMNI 133 Query: 132 VHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD---------------EQFVSLYGT 176 +HR++ N + ++ + DFG AR + D+ ++ ++ G Sbjct: 134 IHRNLNSHNCLVRENKN----VVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGN 189 Query: 177 EEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAA 215 ++ P+M + + Y VD++S G+ Sbjct: 190 PYWMAPEMI--------NGRSYDEKVDVFSFGIVLCEII 220 >5B2L-A nrPDB Length = 324 Score = 177 bits (448), Expect = 2e-44, Method: Composition-based stats. Identities = 69/295 (23%), Positives = 119/295 (40%), Gaps = 26/295 (8%) Query: 1 MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEV-L 59 Q+ N L L ++ G G V++ R +KTG + A+K + + +V L Sbjct: 12 YQAEINDLENLGEM-GSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVL 70 Query: 60 KKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDV 119 K + IV+ F T + ME G+ L++ +PE + + Sbjct: 71 KSHDCPYIVQCFGTFITNTD--VFIAMELM--GTSAEKLKKRMQG-PIPERILGKMTVAI 125 Query: 120 VGGMNHL-RENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEE 178 V + +L ++G++HRD+KP NI+ D + KL DFG + L D + G Sbjct: 126 VKALYYLKEKHGVIHRDVKPSNILL----DERGQIKLCDFGISGRLVDSKAKTRSAGCAA 181 Query: 179 YLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKII 238 Y+ P+ + K Y D+WS+G++ ATG P++ + + EV+ K++ Sbjct: 182 YMAPERIDPPDPTKP---DYDIRADVWSLGISLVELATGQFPYK---NCKTDFEVLTKVL 235 Query: 239 TGKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCW 293 +P G + +SGD P +LE K + Sbjct: 236 QEEPPLLP--------GHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRY 282 >6CCF-A nrPDB Length = 290 Score = 176 bits (446), Expect = 3e-44, Method: Composition-based stats. Identities = 61/241 (25%), Positives = 101/241 (41%), Gaps = 39/241 (16%) Query: 7 HLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFN------------------------- 41 + + L +G+GA V ++ +A+KV + Sbjct: 5 NQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGG 64 Query: 42 NISFLRPVDVQMREFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEP 101 L P++ +E +LKKL+H N+VKL + ++ + L+ + G + V Sbjct: 65 PAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEV---- 120 Query: 102 SNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAA 161 E + + LRDV+ G+ +L IVHRDIKP N++ K+ DFG + Sbjct: 121 PCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDD----GHVKIADFGVS 176 Query: 162 RELE-DDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLP 220 + E +D Q S GT ++ P+ + Q G +D+W+ GVT Y G P Sbjct: 177 NQFEGNDAQLSSTAGTPAFMAPEAISDS-----GQSFSGKALDVWATGVTLYCFVYGKCP 231 Query: 221 F 221 F Sbjct: 232 F 232 >2WTK-C nrPDB Length = 305 Score = 175 bits (445), Expect = 4e-44, Method: Composition-based stats. Identities = 70/295 (23%), Positives = 121/295 (41%), Gaps = 47/295 (15%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ---MREFEVLKKLNHK 65 +L+ D+LG+G+ V +T A+K+ R + + +E ++L++L HK Sbjct: 7 YLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHK 66 Query: 66 NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 125 N+++L + + ++ME+C CG + +L+ P + ++ G+ + Sbjct: 67 NVIQLVDVLYNEEKQKMYMVMEYCVCG-MQEMLDS-VPEKRFPVCQAHGYFCQLIDGLEY 124 Query: 126 LRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELED---DEQFVSLYGTEEYLHP 182 L GIVH+DIKPGN++ G K++ G A L D+ + G+ + P Sbjct: 125 LHSQGIVHKDIKPGNLLLTTG----GTLKISALGVAEALHPFAADDTCRTSQGSPAFQPP 180 Query: 183 DMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKP 242 ++ G VD+WS GVT Y+ TG PF ++ I GK Sbjct: 181 EIANGLDTFS------GFKVDIWSAGVTLYNITTGLYPFEG----DNIYKLFENI--GKG 228 Query: 243 SGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQ 297 S AI G L+ +L +LE + K + Q Sbjct: 229 SYAIPG-----------------------DCGPPLSDLLKGMLEYEPAKRFSIRQ 260 >4AN9-A nrPDB Length = 301 Score = 175 bits (445), Expect = 5e-44, Method: Composition-based stats. Identities = 68/249 (27%), Positives = 107/249 (42%), Gaps = 24/249 (9%) Query: 6 NHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHK 65 + +S+ LG G VF+ HK +G + A K+ + + +RE +VL + N Sbjct: 9 DDFEKISE-LGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSP 67 Query: 66 NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 125 IV + + + ME GSL VL++ +PE V V+ G+ + Sbjct: 68 YIVGFYGAFY--SDGEISICMEHMDGGSLDQVLKKAGR---IPEQILGKVSIAVIKGLTY 122 Query: 126 LRE-NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDM 184 LRE + I+HRD+KP NI+ + + KL DFG + +L DE GT Y+ P+ Sbjct: 123 LREKHKIMHRDVKPSNILV----NSRGEIKLCDFGVSGQLI-DEMANEFVGTRSYMSPER 177 Query: 185 YERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSG 244 + Y D+WS+G++ A G P P E++ I+ P Sbjct: 178 LQGT--------HYSVQSDIWSMGLSLVEMAVGRYP----RPPMAIFELLDYIVNEPPPK 225 Query: 245 AISGVQKAE 253 S V E Sbjct: 226 LPSAVFSLE 234 >5UIU-A nrPDB Length = 323 Score = 175 bits (445), Expect = 5e-44, Method: Composition-based stats. Identities = 52/223 (23%), Positives = 84/223 (37%), Gaps = 23/223 (10%) Query: 12 SDILGQGATANVFRGRHKKTGDLFAIKVF---NNISFLRPVDVQMREFEVLKKLNHKNIV 68 + +G+G V++G T A+K +I+ +E +V+ K H+N+V Sbjct: 52 GNKMGEGGFGVVYKGYVNNT--TVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLV 109 Query: 69 KLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE 128 +L + L+ + P GSL L L + + G+N L E Sbjct: 110 ELLGFSSDGDD--LCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHE 167 Query: 129 NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAAR---ELEDDEQFVSLYGTEEYLHPDMY 185 N +HRDIK NI+ D K++DFG AR + + GT Y+ P+ Sbjct: 168 NHHIHRDIKSANILL----DEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL 223 Query: 186 ERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPR 228 + D++S GV TG P+ Sbjct: 224 RGEI---------TPKSDIYSFGVVLLEIITGLPAVDEHREPQ 257 >6FER-A nrPDB Length = 309 Score = 175 bits (444), Expect = 6e-44, Method: Composition-based stats. Identities = 48/306 (15%), Positives = 97/306 (31%), Gaps = 50/306 (16%) Query: 1 MQSTSNHLWLLSDILGQGATANVFRG--------RHKK--------TGDLFAIKVFNNIS 44 ++ L + LG+G V + K L A+K+ + Sbjct: 3 VEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADA 62 Query: 45 FLRPVDVQMREFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEP--- 101 + ++E +++ +L NI+ L A+ T +I E+ G L L Sbjct: 63 NKNARNDFLKEIKIMSRLKDPNIIHLLAVCI--TDDPLCMITEYMENGDLNQFLSRHEPP 120 Query: 102 ----SNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTD 157 S+ + + + + GM +L VHRD+ N + K+ D Sbjct: 121 NSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVG----KNYTIKIAD 176 Query: 158 FGAARELEDDEQFV---SLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHA 214 FG +R L + + ++ + K+ D+W+ GVT + Sbjct: 177 FGMSRNLYSGDYYRIQGRAVLPIRWMSWESILL--------GKFTTASDVWAFGVTLWET 228 Query: 215 ATG--SLPFRPFEGPRRNK-------EVMYKIITGKPSGAISGVQK-AENGPIDWSGDMP 264 T P+ + + + + +P+ V K + + + P Sbjct: 229 FTFCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRP 288 Query: 265 VSCSLS 270 + Sbjct: 289 SFQEIH 294 >4M7I-A nrPDB Length = 299 Score = 175 bits (443), Expect = 7e-44, Method: Composition-based stats. Identities = 53/230 (23%), Positives = 87/230 (37%), Gaps = 38/230 (16%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 74 LG+G VF ++K +AIK + + MRE + L KL H IV+ F Sbjct: 13 LGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAW 72 Query: 75 EE----------TTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 124 E + + + M+ C +L + S L + + + Sbjct: 73 LEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVE 132 Query: 125 HLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQ-------------FV 171 L G++HRD+KP NI + + V K+ DFG ++ DE+ Sbjct: 133 FLHSKGLMHRDLKPSNIFFTMDD----VVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHT 188 Query: 172 SLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 GT+ Y+ P+ H Y VD++S+G+ + PF Sbjct: 189 GQVGTKLYMSPEQI--------HGNSYSHKVDIFSLGLILFELLY---PF 227 >5LPV-A nrPDB Length = 296 Score = 175 bits (443), Expect = 7e-44, Method: Composition-based stats. Identities = 58/224 (25%), Positives = 93/224 (41%), Gaps = 23/224 (10%) Query: 14 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAI 73 ++G G +V++ K G AIK ++S + M E E + K+ H+N+V L Sbjct: 24 LIGSGGFGDVYKAILK-DGSAVAIKKLIHVSGQGDRE-FMAEMETIGKIKHRNLVPLLGY 81 Query: 74 EEETTTRHKVLIMEFCPCGSLYTVLEEPSNA-YGLPESEFLIVLRDVVGGMNHLR---EN 129 + R +L+ EF GSL VL +P A L S + G+ L Sbjct: 82 CKVGDER--LLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHHNCSP 139 Query: 130 GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQF---VSLYGTEEYLHPDMYE 186 I+HRD+K N++ D +++DFG AR + + +L GT Y+ P+ Y+ Sbjct: 140 HIIHRDMKSSNVLL----DENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYYQ 195 Query: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRN 230 + D++S GV TG P + N Sbjct: 196 SF--------RCSTKGDVYSYGVVLLELLTGKRPTDSPDFGDNN 231 >5LPZ-A nrPDB Length = 332 Score = 175 bits (443), Expect = 8e-44, Method: Composition-based stats. Identities = 58/224 (25%), Positives = 93/224 (41%), Gaps = 23/224 (10%) Query: 14 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAI 73 ++G G +V++ K G AIK ++S + M E E + K+ H+N+V L Sbjct: 24 LIGSGGFGDVYKAILK-DGSAVAIKKLIHVSGQGDRE-FMAEMETIGKIKHRNLVPLLGY 81 Query: 74 EEETTTRHKVLIMEFCPCGSLYTVLEEPSNA-YGLPESEFLIVLRDVVGGMNHLR---EN 129 + R +L+ EF GSL VL +P A L S + G+ L Sbjct: 82 CKVGDER--LLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHHNCSP 139 Query: 130 GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQF---VSLYGTEEYLHPDMYE 186 I+HRD+K N++ D +++DFG AR + + +L GT Y+ P+ Y+ Sbjct: 140 HIIHRDMKSSNVLL----DENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYYQ 195 Query: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRN 230 + D++S GV TG P + N Sbjct: 196 SF--------RCSTKGDVYSYGVVLLELLTGKRPTDSPDFGDNN 231 >5KKR-C nrPDB Length = 395 Score = 174 bits (441), Expect = 1e-43, Method: Composition-based stats. Identities = 62/224 (27%), Positives = 99/224 (44%), Gaps = 20/224 (8%) Query: 6 NHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHK 65 + +S+ LG G VF+ HK +G + A K+ + + +RE +VL + N Sbjct: 68 DDFEKISE-LGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSP 126 Query: 66 NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 125 IV + + + ME GSL VL++ +PE V V+ G+ + Sbjct: 127 YIVGFYGAFY--SDGEISICMEHMDGGSLDQVLKKAGR---IPEQILGKVSIAVIKGLTY 181 Query: 126 LRE-NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDM 184 LRE + I+HRD+KP NI+ + + KL DFG + +L D S GT Y+ P+ Sbjct: 182 LREKHKIMHRDVKPSNILV----NSRGEIKLCDFGVSGQLI-DSMANSFVGTRSYMSPER 236 Query: 185 YERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPR 228 + Y D+WS+G++ A G P P + Sbjct: 237 LQGT--------HYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKE 272 >1S9I-A nrPDB Length = 354 Score = 174 bits (440), Expect = 2e-43, Method: Composition-based stats. Identities = 62/237 (26%), Positives = 102/237 (43%), Gaps = 20/237 (8%) Query: 6 NHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHK 65 + +S+ LG G V + +H+ +G + A K+ + + +RE +VL + N Sbjct: 16 DDFERISE-LGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSP 74 Query: 66 NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 125 IV + + + ME GSL VL+E +PE V V+ G+ + Sbjct: 75 YIVGFYGAFY--SDGEISICMEHMDGGSLDQVLKEAKR---IPEEILGKVSIAVLRGLAY 129 Query: 126 LRENG-IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDM 184 LRE I+HRD+KP NI+ + + KL DFG + +L D S GT Y+ P+ Sbjct: 130 LREKHQIMHRDVKPSNILV----NSRGEIKLCDFGVSGQLI-DSMANSFVGTRSYMAPER 184 Query: 185 YERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 241 + Y D+WS+G++ A G P P + ++ G+ Sbjct: 185 LQGT--------HYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGE 233 >4TPT-A nrPDB Length = 303 Score = 174 bits (440), Expect = 2e-43, Method: Composition-based stats. Identities = 43/225 (19%), Positives = 86/225 (38%), Gaps = 39/225 (17%) Query: 12 SDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLF 71 ++LG+G + HK TG + +K + E +V++ L+H N++K Sbjct: 5 GEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQK-TFLTEVKVMRSLDHPNVLKFI 63 Query: 72 AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGI 131 + + + L+ E+ G+L L P + + + + GM +L I Sbjct: 64 GVLYKDKKLN--LLTEYIEGGTLKDFLRSMD---PFPWQQKVRFAKGIASGMAYLHSMCI 118 Query: 132 VHRDIKPGNIMRVIGEDGQSVYKLTDFGAAREL---------------------EDDEQF 170 +HRD+ N + + + + DFG +R + D ++ Sbjct: 119 IHRDLNSHNCLIKLDK----TVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKR 174 Query: 171 VSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAA 215 ++ G ++ P+M + K Y TVD++S G+ Sbjct: 175 YTVVGNPYWMAPEML--------NGKSYDETVDIFSFGIVLCEII 211 >3EQC-A nrPDB Length = 360 Score = 173 bits (438), Expect = 3e-43, Method: Composition-based stats. Identities = 62/224 (27%), Positives = 99/224 (44%), Gaps = 20/224 (8%) Query: 6 NHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHK 65 + +S+ LG G VF+ HK +G + A K+ + + +RE +VL + N Sbjct: 33 DDFEKISE-LGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSP 91 Query: 66 NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 125 IV + + + ME GSL VL++ +PE V V+ G+ + Sbjct: 92 YIVGFYGAFY--SDGEISICMEHMDGGSLDQVLKKAGR---IPEQILGKVSIAVIKGLTY 146 Query: 126 LRE-NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDM 184 LRE + I+HRD+KP NI+ + + KL DFG + +L D S GT Y+ P+ Sbjct: 147 LREKHKIMHRDVKPSNILV----NSRGEIKLCDFGVSGQLI-DSMANSFVGTRSYMSPER 201 Query: 185 YERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPR 228 + Y D+WS+G++ A G P P + Sbjct: 202 LQGT--------HYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKE 237 >4EQM-A nrPDB Length = 294 Score = 173 bits (438), Expect = 3e-43, Method: Composition-based stats. Identities = 56/222 (25%), Positives = 87/222 (39%), Gaps = 21/222 (9%) Query: 6 NHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVF--NNISFLRPVDVQMREFEVLKKLN 63 N + + D LG G + V+ AIK + RE +L+ Sbjct: 10 NERYKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETLKRFEREVHNSSQLS 69 Query: 64 HKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 123 H+NIV + ++EE L+ME+ +L +E L + ++ G+ Sbjct: 70 HQNIVSMIDVDEE--DDCYYLVMEYIEGPTLSEYIESHG---PLSVDTAINFTNQILDGI 124 Query: 124 NHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDE--QFVSLYGTEEYLH 181 H + IVHRDIKP NI+ D K+ DFG A+ L + Q + GT +Y Sbjct: 125 KHAHDMRIVHRDIKPQNILI----DSNKTLKIFDFGIAKALSETSLTQTNHVLGTVQYFS 180 Query: 182 PDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRP 223 P+ + D++SIG+ Y G PF Sbjct: 181 PEQAKGEAT--------DECTDIYSIGIVLYEMLVGEPPFNG 214 >1ZXE-A nrPDB Length = 303 Score = 172 bits (435), Expect = 6e-43, Method: Composition-based stats. Identities = 59/287 (20%), Positives = 105/287 (36%), Gaps = 45/287 (15%) Query: 14 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAI 73 +LGQGA V + R+ +AIK + + + E +L LNH+ +V+ +A Sbjct: 13 VLGQGAFGQVVKARNALDSRYYAIKKIRHTE--EKLSTILSEVMLLASLNHQYVVRYYAA 70 Query: 74 EEE-----------TTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGG 122 E + ME+C +LY ++ + E+ + R ++ Sbjct: 71 WLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQ--RDEYWRLFRQILEA 128 Query: 123 MNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELE---------------DD 167 ++++ GI+HR++KP NI D K+ DFG A+ + Sbjct: 129 LSYIHSQGIIHRNLKPMNIFI----DESRNVKIGDFGLAKNVHRSLDILKLDSQNLPGSS 184 Query: 168 EQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGP 227 + S GT Y+ ++ D Y +D++S+G+ F+ PF Sbjct: 185 DNLTSAIGTAMYVATEVL-------DGTGHYNEKIDMYSLGIIFFEMIY---PFSTGMER 234 Query: 228 RRNKEVMYKIITGKPSGAISGVQKAENGPIDWSGDM-PVSCSLSRGL 273 + + + P K E I D P +R L Sbjct: 235 VNILKKLRSVSIEFPPDFDDNKMKVEKKIIRLLIDHDPNKRPGARTL 281 >3N9X-A nrPDB Length = 432 Score = 171 bits (434), Expect = 8e-43, Method: Composition-based stats. Identities = 53/246 (21%), Positives = 94/246 (38%), Gaps = 46/246 (18%) Query: 1 MQSTSN----HLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNI-SFLRPVDVQMRE 55 Q N +++ ++G+G+ V+ K T AIK N + L +RE Sbjct: 16 FQGIKNVHVPDNYIIKHLIGRGSYGYVYLAYDKNTEKNVAIKKVNRMFEDLIDCKRILRE 75 Query: 56 FEVLKKLNHKNIVKLFAIEEETT---TRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEF 112 +L +L I++L+ + +++E L + + P L E Sbjct: 76 ITILNRLKSDYIIRLYDLIIPDDLLKFDELYIVLEIADS-DLKKLFKTP---IFLTEEHI 131 Query: 113 LIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD----- 167 +L +++ G N + E+GI+HRD+KP N + + K+ DFG AR + + Sbjct: 132 KTILYNLLLGENFIHESGIIHRDLKPANCLL----NQDCSVKVCDFGLARTINSEKDTNI 187 Query: 168 ------------------EQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGV 209 +Q S T Y P++ Q+ Y ++D+WS G Sbjct: 188 VNDLEENEEPGPHNKNLKKQLTSHVVTRWYRAPELI-------LLQENYTKSIDIWSTGC 240 Query: 210 TFYHAA 215 F Sbjct: 241 IFAELL 246 >3DLS-A nrPDB Length = 335 Score = 170 bits (432), Expect = 2e-42, Method: Composition-based stats. Identities = 60/233 (25%), Positives = 92/233 (39%), Gaps = 24/233 (10%) Query: 2 QSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ-------MR 54 + + + LG GA V+ K+ +K L ++ Sbjct: 19 EGEYSQKYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTL 78 Query: 55 EFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCG-SLYTVLEEPSNAYGLPESEFL 113 E +L ++ H NI+K+ I E L+ME G L+ ++ L E Sbjct: 79 EIAILSRVEHANIIKVLDIFENQGFFQ--LVMEKHGSGLDLFAFIDRHPR---LDEPLAS 133 Query: 114 IVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSL 173 + R +V + +LR I+HRDIK NI+ KL DFG+A LE + F + Sbjct: 134 YIFRQLVSAVGYLRLKDIIHRDIKDENIVIAED----FTIKLIDFGSAAYLERGKLFYTF 189 Query: 174 YGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEG 226 GT EY P++ R G +++WS+GVT Y PF E Sbjct: 190 CGTIEYCAPEVLMGNPYR-------GPELEMWSLGVTLYTLVFEENPFCELEE 235 >4X7Q-B nrPDB Length = 312 Score = 170 bits (431), Expect = 2e-42, Method: Composition-based stats. Identities = 67/284 (23%), Positives = 106/284 (37%), Gaps = 38/284 (13%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFL--RPVDVQMR---EFEVLKKLN 63 + L +LG+G VF G AIKV L P+ + E +L K+ Sbjct: 33 YRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVG 92 Query: 64 ----HKNIVKLFAIEEETTTRHKVLIME-FCPCGSLYTVLEEPSNAYGLPESEFLIVLRD 118 H +++L E T +L++E P L+ + E L E Sbjct: 93 AGGGHPGVIRLLDWFE--TQEGFMLVLERPLPAQDLFDYITEKG---PLGEGPSRCFFGQ 147 Query: 119 VVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEE 178 VV + H G+VHRDIK NI+ + + KL DFG+ L DE + GT Sbjct: 148 VVAAIQHCHSRGVVHRDIKDENILIDL---RRGCAKLIDFGSGALLH-DEPYTDFDGTRV 203 Query: 179 YLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKII 238 Y P+ R + + +WS+G+ Y G +PF R++E++ + Sbjct: 204 YSPPEWISR-------HQYHALPATVWSLGILLYDMVCGDIPFE------RDQEILEAEL 250 Query: 239 TGKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLA 282 P+ + P S ++LL P + Sbjct: 251 HF-PAHVSPDCCALIRRCLA-----PKPSSRPSLEEILLDPWMQ 288 >2A1A-B nrPDB Length = 284 Score = 170 bits (430), Expect = 3e-42, Method: Composition-based stats. Identities = 53/217 (24%), Positives = 95/217 (43%), Gaps = 32/217 (14%) Query: 13 DILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKL-- 70 +++G G VF+ +H+ G + IK + RE + L KL+H NIV Sbjct: 17 ELIGSGGFGQVFKAKHRIDGKTYVIKRVKY-----NNEKAEREVKALAKLDHVNIVHYNG 71 Query: 71 ----FAIEEETTTRH--------KVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRD 118 F + ET++++ + MEFC G+L +E+ L + L + Sbjct: 72 CWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEK-RRGEKLDKVLALELFEQ 130 Query: 119 VVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEE 178 + G++++ +++RD+KP NI V + K+ DFG L++D + GT Sbjct: 131 ITKGVDYIHSKKLINRDLKPSNIFLVDTKQ----VKIGDFGLVTSLKNDGKRTRSKGTLR 186 Query: 179 YLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAA 215 Y+ P+ + YG VDL+++G+ Sbjct: 187 YMSPEQIS--------SQDYGKEVDLYALGLILAELL 215 >3VN9-A nrPDB Length = 340 Score = 169 bits (429), Expect = 3e-42, Method: Composition-based stats. Identities = 48/237 (20%), Positives = 95/237 (40%), Gaps = 18/237 (7%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEV-LKKLNHKNIVKLFAI 73 LG+GA V + RH +G + A+K + + + ++ ++ ++ V + Sbjct: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGA 118 Query: 74 EEETTTRHKVLIMEFCPCGSLYTVLEE-PSNAYGLPESEFLIVLRDVVGGMNHLREN-GI 131 + ME SL ++ +PE + +V + HL + Sbjct: 119 LFREGD--VWICMELMD-TSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSV 175 Query: 132 VHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLR 191 +HRD+KP N++ + K+ DFG + L D G + Y+ P+ + Sbjct: 176 IHRDVKPSNVLI----NALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPEL-- 229 Query: 192 KDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISG 248 +QK Y D+WS+G+T A P+ + P + + +++ +PS + Sbjct: 230 --NQKGYSVKSDIWSLGITMIELAILRFPYDSWGTP---FQQLKQVVE-EPSPQLPA 280 >1TKI-A nrPDB Length = 321 Score = 169 bits (429), Expect = 4e-42, Method: Composition-based stats. Identities = 62/287 (21%), Positives = 117/287 (40%), Gaps = 22/287 (7%) Query: 7 HLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKN 66 +++++ LG+G V R + + K + + +E +L H+N Sbjct: 5 EKYMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGTDQVL--VKKEISILNIARHRN 62 Query: 67 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 126 I+ L E V+I EF ++ + ++A+ L E E + + V + L Sbjct: 63 ILHLHESFESM--EELVMIFEFISGLDIFERI--NTSAFELNEREIVSYVHQVCEALQFL 118 Query: 127 RENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYE 186 + I H DI+P NI + S K+ +FG AR+L+ + F L+ EY P++++ Sbjct: 119 HSHNIGHFDIRPENI--IYQTRRSSTIKIIEFGQARQLKPGDNFRLLFTAPEYYAPEVHQ 176 Query: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAI 246 V+ D+WS+G Y +G PF N++++ I+ + + Sbjct: 177 HDVV--------STATDMWSLGTLVYVLLSGINPFLA----ETNQQIIENIMNAEYTFDE 224 Query: 247 SGVQKAENGPIDWSGDMPVSCSLSR--GLQVLLTPVLANILEADQEK 291 ++ +D+ + V SR + L P L +E K Sbjct: 225 EAFKEISIEAMDFVDRLLVKERKSRMTASEALQHPWLKQKIERVSTK 271 >3FME-A nrPDB Length = 290 Score = 169 bits (428), Expect = 4e-42, Method: Composition-based stats. Identities = 51/251 (20%), Positives = 103/251 (41%), Gaps = 19/251 (7%) Query: 1 MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEV-L 59 M+ ++ L + + LG+GA V + RH +G + A+K + + + ++ + Sbjct: 2 MEVKADDLEPIME-LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISM 60 Query: 60 KKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEE-PSNAYGLPESEFLIVLRD 118 + ++ V + + ME SL ++ +PE + Sbjct: 61 RTVDCPFTVTFYGALFREGD--VWICMELMD-TSLDKFYKQVIDKGQTIPEDILGKIAVS 117 Query: 119 VVGGMNHLREN-GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTE 177 +V + HL ++HRD+KP N++ + K+ DFG + L DD G + Sbjct: 118 IVKALEHLHSKLSVIHRDVKPSNVLI----NALGQVKMCDFGISGYLVDDVAKDIDAGCK 173 Query: 178 EYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKI 237 Y+ P+ + +QK Y D+WS+G+T A P+ + P + + ++ Sbjct: 174 PYMAPERINPEL----NQKGYSVKSDIWSLGITMIELAILRFPYDSWGTP---FQQLKQV 226 Query: 238 ITGKPSGAISG 248 + +PS + Sbjct: 227 VE-EPSPQLPA 236 >5O0Y-A nrPDB Length = 579 Score = 169 bits (427), Expect = 6e-42, Method: Composition-based stats. Identities = 57/229 (24%), Positives = 95/229 (41%), Gaps = 25/229 (10%) Query: 20 TANVFRGRHKKTGDLFAIKVF------NNISFLRPVDVQMREFEVLKKLNHKNIVKLFAI 73 + V++ A+K+ + RE+ + K+L+H IVKL+ Sbjct: 297 FSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDY 356 Query: 74 EEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE--NGI 131 T ++E+C L L++ + E E ++ +V + +L E I Sbjct: 357 FSLDTDSF-CTVLEYCEGNDLDFYLKQHK---LMSEKEARSIIMQIVNALKYLNEIKPPI 412 Query: 132 VHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD--------EQFVSLYGTEEYLHPD 183 +H D+KPGNI+ V G K+TDFG ++ ++DD E GT YL P+ Sbjct: 413 IHYDLKPGNILLVNGT-ACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPE 471 Query: 184 MYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKE 232 + + K VD+WS+GV FY G PF + + + Sbjct: 472 CF----VVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQ 516 >3NIE-A nrPDB Length = 429 Score = 168 bits (426), Expect = 7e-42, Method: Composition-based stats. Identities = 67/381 (17%), Positives = 125/381 (32%), Gaps = 81/381 (21%) Query: 7 HLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNI-SFLRPVDVQMREFEVLKKLNHK 65 + + ++G+G+ V+ K AIK N + L +RE +L +L Sbjct: 28 DNYEIKHLIGRGSYGYVYLAYDKNANKNVAIKKVNRMFEDLIDCKRILREITILNRLKSD 87 Query: 66 NIVKLFAIEEETT---TRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGG 122 I++L + +++E L + + P L E +L +++ G Sbjct: 88 YIIRLHDLIIPEDLLKFDELYIVLEIADS-DLKKLFKTP---IFLTEQHVKTILYNLLLG 143 Query: 123 MNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD--------------- 167 + E+GI+HRD+KP N + + K+ DFG AR + D Sbjct: 144 EKFIHESGIIHRDLKPANCLL----NQDCSVKICDFGLARTINSDKDIHIVNDLEEKEEN 199 Query: 168 -----------EQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAA- 215 +Q S T Y P++ Q+ Y ++D+WS G F Sbjct: 200 EEPGPHNKNLKKQLTSHVVTRWYRAPELI-------LLQENYTNSIDIWSTGCIFAELLN 252 Query: 216 ---------TGSLPFRPFE--------------GPRRNKEVMYKI--ITGKPSGAISGVQ 250 T P P + N++ + I + G P Sbjct: 253 MMKSHINNPTNRFPLFPGSSCFPLSPDHNSKKVHEKSNRDQLNIIFNVIGTPPEEDLKCI 312 Query: 251 KAENGPIDWSGDMPVSCSL-----SRGLQVLLTPVLANILEADQEKCWGFDQFFAETSDI 305 + I + P + + +L ++L + +K D S Sbjct: 313 TKQEV-IKYIKLFPTRDGIDLSKKYSSISKEGIDLLESMLRFNAQKRITID---KALSHP 368 Query: 306 LHRMVIHVFSLQQMTAHKIYI 326 + + +L+ + KI + Sbjct: 369 -YLKDVRKENLENFSTEKIIL 388 >6CTH-A nrPDB Length = 309 Score = 168 bits (425), Expect = 8e-42, Method: Composition-based stats. Identities = 58/214 (27%), Positives = 94/214 (43%), Gaps = 22/214 (10%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 74 LG+G +V+RG + + A+K + S + E +++ +L HKN+VKL Sbjct: 23 LGEGGFGSVYRGFLRDSDTYIAVKKVSRASKQGIKEYA-SEVKIISRLRHKNLVKLIGWC 81 Query: 75 EETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG---I 131 E +L+ EF GSL + + + + L +++D+ + +L E G + Sbjct: 82 HERG--ELMLVYEFMANGSLDSHIFKGKSL--LTWEVRYRIVKDLASALLYLHEEGDHCV 137 Query: 132 VHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDE--QFVSLYGTEEYLHPDMYERAV 189 +HRDIK NIM D KL DFG AR ++ + + L GT Y+ P+ Sbjct: 138 LHRDIKTSNIML----DSSFNAKLGDFGLARLVDHAKGLKKTLLAGTVGYMAPECLS--- 190 Query: 190 LRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRP 223 K D++S GV A+G P Sbjct: 191 -----SGKASKESDVYSFGVVALEIASGRRSIEP 219 >4FL3-A nrPDB Length = 635 Score = 168 bits (425), Expect = 8e-42, Method: Composition-based stats. Identities = 59/269 (21%), Positives = 112/269 (41%), Gaps = 31/269 (11%) Query: 12 SDILGQGATANVFRGRHK-----KTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKN 66 LG G V +G ++ KT + +K N + D + E V+++L++ Sbjct: 374 DKELGSGNFGTVKKGYYQMKKVVKTVAVKILK--NEANDPALKDELLAEANVMQQLDNPY 431 Query: 67 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 126 IV++ I E + +L+ME G L L++ + + + + ++ V GM +L Sbjct: 432 IVRMIGICEAESW---MLVMEMAELGPLNKYLQQNRH---VKDKNIIELVHQVSMGMKYL 485 Query: 127 RENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYG----TEEYLHP 182 E+ VHRD+ N++ V Q K++DFG ++ L DE + ++ P Sbjct: 486 EESNFVHRDLAARNVLLVT----QHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAP 541 Query: 183 DMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVMYKIITGK 241 + + K+ + D+WS GV + A + G P+R +G + G Sbjct: 542 ECI--------NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGC 593 Query: 242 PSGAISGVQKAENGPIDWS-GDMPVSCSL 269 P+G + N + + P ++ Sbjct: 594 PAGCPREMYDLMNLCWTYDVENRPGFAAV 622 >5XD6-A nrPDB Length = 305 Score = 168 bits (425), Expect = 8e-42, Method: Composition-based stats. Identities = 62/293 (21%), Positives = 108/293 (36%), Gaps = 46/293 (15%) Query: 14 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAI 73 ++G+G+ VF G K +G AIK + S +P + + ++ +L +N+V L Sbjct: 29 LIGEGSYGRVFYGILK-SGKAAAIKKLD--SSKQPDQEFLAQVSMVSRLRQENVVALLGY 85 Query: 74 EEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYG------LPESEFLIVLRDVVGGMNHLR 127 + R VL E+ P GSL+ +L G L + + + G+ +L Sbjct: 86 CVDGPLR--VLAYEYAPNGSLHDILHGRKGVKGAQPGPVLSWHQRVKIAVGAARGLEYLH 143 Query: 128 EN---GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDE---QFVSLYGTEEYLH 181 E ++HRDIK N++ + V K+ DF + + D + GT Y Sbjct: 144 EKANPHVIHRDIKSSNVLLFDDD----VAKIADFDLSNQAPDMAARLHSTRVLGTFGYHA 199 Query: 182 PDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLP----------------FRPFE 225 P+ L D++S GV TG P Sbjct: 200 PEYAMTGTL--------STKSDVYSFGVVLLELLTGRKPVDHTLPRGQQSVVTWATPKLS 251 Query: 226 GPRRNKEVMYKIITGKPSGAISGVQKAENGPIDWSGD-MPVSCSLSRGLQVLL 277 + + V ++ P A++ + + + D P + + LQ LL Sbjct: 252 EDKVKQCVDARLNGEYPPKAVAKLAAVAALCVQYEADFRPNMSIVVKALQPLL 304 >6O6Q-A nrPDB Length = 335 Score = 167 bits (424), Expect = 1e-41, Method: Composition-based stats. Identities = 43/238 (18%), Positives = 92/238 (38%), Gaps = 21/238 (8%) Query: 5 SNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKL-N 63 + + LG+G + VF G + + IKV + + RE +LK L + Sbjct: 39 PQENYEILRKLGRGKYSEVFLGIDLEKREKVVIKVLKPVKRKK----IKREISILKNLVD 94 Query: 64 HKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 123 NI+ + + E ++ LI E ++ S + + + +++ + Sbjct: 95 GPNIIAMLDVVREPQSKTPGLIFEHINN------IDFRSLYPTFTDYDIRFYMYELLKAL 148 Query: 124 NHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPD 183 ++ GI+HRD+KP N+M + + + +L D+G A ++ + + P+ Sbjct: 149 DYSHSMGIMHRDVKPHNVMI---DHDKKLLRLIDWGLAEYYHPGTEYNVRVASRYFKGPE 205 Query: 184 MYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 241 + + Y ++D+WS G PF + + +++ K Sbjct: 206 LLVD-------YRLYDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQLVQIVRVLGSK 256 >5TOS-A nrPDB Length = 395 Score = 167 bits (423), Expect = 1e-41, Method: Composition-based stats. Identities = 59/221 (26%), Positives = 89/221 (40%), Gaps = 30/221 (13%) Query: 14 ILGQGATANVFRG---------RHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNH 64 ++G+G VF+G TG + A+K N F + + E L +L+H Sbjct: 72 VIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHRE-WLTEINYLGQLSH 130 Query: 65 KNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAY-GLPESEFLIVLRDVVGGM 123 N+VKL E H++L+ EF GSL L + LP + V D G+ Sbjct: 131 PNLVKLIGYCLE--DEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGL 188 Query: 124 NHLREN--GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARE--LEDDEQFVSLY-GTEE 178 L + +++RDIK NI+ D KL+DFG AR+ + D + GT Sbjct: 189 AFLHSDPVKVIYRDIKASNILL----DADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYG 244 Query: 179 YLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSL 219 Y P+ L D++S GV +G Sbjct: 245 YAAPEYMSSGHLNA--------RSDVYSFGVLLLEILSGKR 277 >4IDT-A nrPDB Length = 356 Score = 167 bits (423), Expect = 2e-41, Method: Composition-based stats. Identities = 57/216 (26%), Positives = 82/216 (37%), Gaps = 28/216 (12%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 74 LG+G+ V R K+TG A+K F E L IV L+ Sbjct: 82 LGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRAE------ELMACAGLTSPRIVPLYGAV 135 Query: 75 EETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHR 134 E + + ME GSL +++E LPE L L + G+ +L I+H Sbjct: 136 REGPWVN--IFMELLEGGSLGQLVKEQGC---LPEDRALYYLGQALEGLEYLHSRRILHG 190 Query: 135 DIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLY------GTEEYLHPDMYERA 188 D+K N++ S L DFG A L+ D L GTE ++ P++ Sbjct: 191 DVKADNVLLSSD---GSHAALCDFGHAVCLQPDGLGKDLLTGDYIPGTETHMAPEVVLG- 246 Query: 189 VLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPF 224 + A VD+WS H G P+ F Sbjct: 247 -------RSCDAKVDVWSSCCMMLHMLNGCHPWTQF 275 >6B2Q-A nrPDB Length = 317 Score = 166 bits (421), Expect = 3e-41, Method: Composition-based stats. Identities = 54/227 (23%), Positives = 86/227 (37%), Gaps = 22/227 (9%) Query: 4 TSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRP--VDVQMREFEVLKK 61 T + + L ++ G V+ + G A+KV + P ++ E Sbjct: 29 TLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAM 88 Query: 62 LNHKNIVKLFAIEE---ETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRD 118 LNH I + E R L+ME L +VL+ L L +L Sbjct: 89 LNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGR---LSLRHALDMLEQ 145 Query: 119 VVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVS--LYGT 176 + G+VHRD+KPGNI+ K+TDFG A+ ++ + + GT Sbjct: 146 TGRALQIAHAAGLVHRDVKPGNILIT----PTGQVKITDFGIAKAVDAAPVTQTGMVMGT 201 Query: 177 EEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRP 223 +Y+ P+ D++S+GV Y A +G PF Sbjct: 202 AQYIAPEQALGHDA--------SPASDVYSLGVVGYEAVSGKRPFAG 240 >4X3F-A nrPDB Length = 337 Score = 166 bits (421), Expect = 3e-41, Method: Composition-based stats. Identities = 54/227 (23%), Positives = 86/227 (37%), Gaps = 22/227 (9%) Query: 4 TSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRP--VDVQMREFEVLKK 61 T + + L ++ G V+ + G A+KV + P ++ E Sbjct: 9 TLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAM 68 Query: 62 LNHKNIVKLFAIEE---ETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRD 118 LNH I + E R L+ME L +VL+ L L +L Sbjct: 69 LNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGR---LSLRHALDMLEQ 125 Query: 119 VVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVS--LYGT 176 + G+VHRD+KPGNI+ K+TDFG A+ ++ + + GT Sbjct: 126 TGRALQIAHAAGLVHRDVKPGNILIT----PTGQVKITDFGIAKAVDAAPVTQTGMVMGT 181 Query: 177 EEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRP 223 +Y+ P+ D++S+GV Y A +G PF Sbjct: 182 AQYIAPEQALGHDA--------SPASDVYSLGVVGYEAVSGKRPFAG 220 >4OW8-A nrPDB Length = 283 Score = 166 bits (421), Expect = 3e-41, Method: Composition-based stats. Identities = 54/227 (23%), Positives = 86/227 (37%), Gaps = 22/227 (9%) Query: 4 TSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRP--VDVQMREFEVLKK 61 T + + L ++ G V+ + G A+KV + P ++ E Sbjct: 8 TLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAM 67 Query: 62 LNHKNIVKLFAIEE---ETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRD 118 LNH I + E R L+ME L +VL+ L L +L Sbjct: 68 LNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGR---LSLRHALDMLEQ 124 Query: 119 VVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVS--LYGT 176 + G+VHRD+KPGNI+ K+TDFG A+ ++ + + GT Sbjct: 125 TGRALQIAHAAGLVHRDVKPGNILIT----PTGQVKITDFGIAKAVDAAPVTQTGMVMGT 180 Query: 177 EEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRP 223 +Y+ P+ D++S+GV Y A +G PF Sbjct: 181 AQYIAPEQALGHDA--------SPASDVYSLGVVGYEAVSGKRPFAG 219 >3RP9-A nrPDB Length = 458 Score = 165 bits (418), Expect = 5e-41, Method: Composition-based stats. Identities = 51/241 (21%), Positives = 88/241 (36%), Gaps = 47/241 (19%) Query: 7 HLWLLSDILGQGATANVFRGRHKKTGDLFAIK-VFNNISFLRPVDVQMREFEVLKKLNHK 65 + + ++G G+ +V K + AIK + L +RE +L +LNH Sbjct: 53 DRYEIRHLIGTGSYGHVCEAYDKLEKRVVAIKKILRVFEDLIDCKRILREIAILNRLNHD 112 Query: 66 NIVKLFAIEEETT---TRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGG 122 ++VK+ I +++E + L E +L +++ G Sbjct: 113 HVVKVLDIVIPKDVEKFDELYVVLEIADS----DFKKLFRTPVYLTELHIKTLLYNLLVG 168 Query: 123 MNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAAREL---------------EDD 167 + ++ GI+HRD+KP N + + K+ DFG AR + EDD Sbjct: 169 VKYVHSAGILHRDLKPANCLV----NQDCSVKVCDFGLARTVDYPENGNSQLPISPREDD 224 Query: 168 EQFVSL-------------YGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHA 214 V+ T Y P++ Q+ Y +D+WSIG F Sbjct: 225 MNLVTFPHTKNLKRQLTGHVVTRWYRAPELI-------LLQENYTEAIDVWSIGCIFAEL 277 Query: 215 A 215 Sbjct: 278 L 278 >2WO6-A nrPDB Length = 382 Score = 165 bits (418), Expect = 6e-41, Method: Composition-based stats. Identities = 59/291 (20%), Positives = 108/291 (37%), Gaps = 32/291 (10%) Query: 7 HLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNIS-FLRPVDVQMREFEVLKKLNHK 65 + + ++G+G+ V + + + AIK+ N FL +++R E++ K H Sbjct: 54 DRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNK--HD 111 Query: 66 -----NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVV 120 IV L H L+ E +LY +L +N G+ + + + Sbjct: 112 TEMKYYIVHLKRHFMFRN--HLCLVFEMLSY-NLYDLLR-NTNFRGVSLNLTRKFAQQMC 167 Query: 121 GGMNHLR--ENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEE 178 + L E I+H D+KP NI+ +S K+ DFG++ +L ++ + Sbjct: 168 TALLFLATPELSIIHCDLKPENILLC--NPKRSAIKIVDFGSSCQL--GQRIYQYIQSRF 223 Query: 179 YLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKII 238 Y P++ Y +D+WS+G TG F + +++ + Sbjct: 224 YRSPEVLLGM--------PYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVE--V 273 Query: 239 TGKPSGAISGVQKAENGPIDWSGD----MPVSCSLSRGLQVLLTPVLANIL 285 G P I + D + + R + T L NIL Sbjct: 274 LGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNIL 324 >4G3E-A nrPDB Length = 352 Score = 165 bits (418), Expect = 6e-41, Method: Composition-based stats. Identities = 67/282 (23%), Positives = 109/282 (38%), Gaps = 38/282 (13%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 74 +G+G+ V R + K+TG A+K F ++ E L+ IV L+ Sbjct: 82 VGRGSFGEVHRMKDKQTGFQCAVKKVRLEVF------RVEELVACAGLSSPRIVPLYGAV 135 Query: 75 EETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHR 134 E + + ME GSL ++++ LPE L L + G+ +L I+H Sbjct: 136 REGPWVN--IFMELLEGGSLGQLIKQMGC---LPEDRALYYLGQALEGLEYLHTRRILHG 190 Query: 135 DIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLY------GTEEYLHPDMYERA 188 D+K N++ + L DFG A L+ D SL GTE ++ P++ Sbjct: 191 DVKADNVLLSSDGSRAA---LCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPEVVMG- 246 Query: 189 VLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF-RPFEGPRRNK------EVMYKIITGK 241 K A VD+WS H G P+ + F GP K + + Sbjct: 247 -------KPCDAKVDIWSSCCMMLHMLNGCHPWTQYFRGPLCLKIASEPPPIREIPPSCA 299 Query: 242 PSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQV---LLTPV 280 P A + + P+ + M + + + LQ L +P Sbjct: 300 PLTAQAIQEGLRKEPVHRASAMELRRKVGKALQEVGGLKSPW 341 >3ZZW-A nrPDB Length = 289 Score = 165 bits (417), Expect = 7e-41, Method: Composition-based stats. Identities = 47/287 (16%), Positives = 103/287 (35%), Gaps = 37/287 (12%) Query: 11 LSDILGQGATANVFRGRH-----KKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHK 65 + LG+ V++G + AIK + + + E + +L H Sbjct: 13 FMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRARLQHP 72 Query: 66 NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVL-------------EEPSNAYGLPESEF 112 N+V L + T + +I +C G L+ L ++ + L +F Sbjct: 73 NVVCLLGVV--TKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDF 130 Query: 113 LIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVS 172 + ++ + GM +L + +VH+D+ N++ + K++D G RE+ + + Sbjct: 131 VHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLN----VKISDLGLFREVYAADYYKL 186 Query: 173 LYGTE---EYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPR 228 L + ++ P+ K+ D+WS GV + + G P+ + Sbjct: 187 LGNSLLPIRWMAPEAIM--------YGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQD 238 Query: 229 RNKEVMYKIITGKPSGAISGV-QKAENGPIDWSGDMPVSCSLSRGLQ 274 + + + + P + V ++ P + L+ Sbjct: 239 VVEMIRNRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDIHSRLR 285 >5C26-A nrPDB Length = 299 Score = 165 bits (417), Expect = 8e-41, Method: Composition-based stats. Identities = 59/269 (21%), Positives = 112/269 (41%), Gaps = 31/269 (11%) Query: 12 SDILGQGATANVFRGRHK-----KTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKN 66 LG G V +G ++ KT + +K N + D + E V+++L++ Sbjct: 32 DKELGSGNFGTVKKGYYQMKKVVKTVAVKILK--NEANDPALKDELLAEANVMQQLDNPY 89 Query: 67 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 126 IV++ I E + +L+ME G L L++ + + + + ++ V GM +L Sbjct: 90 IVRMIGICEAESW---MLVMEMAELGPLNKYLQQNRH---VKDKNIIELVHQVSMGMKYL 143 Query: 127 RENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYG----TEEYLHP 182 E+ VHRD+ N++ V Q K++DFG ++ L DE + ++ P Sbjct: 144 EESNFVHRDLAARNVLLVT----QHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAP 199 Query: 183 DMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVMYKIITGK 241 + + K+ + D+WS GV + A + G P+R +G + G Sbjct: 200 ECI--------NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGC 251 Query: 242 PSGAISGVQKAENGPIDWS-GDMPVSCSL 269 P+G + N + + P ++ Sbjct: 252 PAGCPREMYDLMNLCWTYDVENRPGFAAV 280 >3UIU-A nrPDB Length = 306 Score = 165 bits (417), Expect = 9e-41, Method: Composition-based stats. Identities = 51/230 (22%), Positives = 91/230 (39%), Gaps = 45/230 (19%) Query: 13 DILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFA 72 +++G G VF+ +H+ G + I+ + RE + L KL+H NIV Sbjct: 18 ELIGSGGFGQVFKAKHRIDGKTYVIRRVKY-----NNEKAEREVKALAKLDHVNIVHYNG 72 Query: 73 IEE---------------------------ETTTRHKVLIMEFCPCGSLYTVLEEPSNAY 105 + + T+ + MEFC G+L +E+ Sbjct: 73 CWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEK-RRGE 131 Query: 106 GLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELE 165 L + L + + G++++ ++HRD+KP NI V + K+ DFG L+ Sbjct: 132 KLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQ----VKIGDFGLVTSLK 187 Query: 166 DDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAA 215 +D + GT Y+ P+ + YG VDL+++G+ Sbjct: 188 NDGKRTRSKGTLRYMSPEQIS--------SQDYGKEVDLYALGLILAELL 229 >3M42-A nrPDB Length = 299 Score = 164 bits (414), Expect = 2e-40, Method: Composition-based stats. Identities = 55/255 (21%), Positives = 104/255 (40%), Gaps = 43/255 (16%) Query: 3 STSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVL-KK 61 + + + S +LG G V + +K+T + FA+K+ + RE E+ + Sbjct: 14 AIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML------QDCPKARREVELHWRA 67 Query: 62 LNHKNIVKLFAIEEE--TTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDV 119 +IV++ + E + +++ME G L++ +++ + E E +++ + Sbjct: 68 SQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGD-QAFTEREASEIMKSI 126 Query: 120 VGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEY 179 + +L I HRD+KP N + + ++ KLTDFG A+E Sbjct: 127 GEAIQYLHSINIAHRDVKPEN-LLYTSKRPNAILKLTDFGFAKE---------------- 169 Query: 180 LHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIIT 239 +KY + D+WS+GV Y G PF G + + +I Sbjct: 170 -------------TTGEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRM 216 Query: 240 GK---PSGAISGVQK 251 G+ P+ S V + Sbjct: 217 GQYEFPNPEWSEVSE 231 >5WNO-A nrPDB Length = 330 Score = 163 bits (413), Expect = 2e-40, Method: Composition-based stats. Identities = 54/275 (19%), Positives = 104/275 (37%), Gaps = 28/275 (10%) Query: 11 LSDILGQGATANVFRGRH-----KKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHK 65 L LG GA VF G + K AIKVF + D + E + +L H Sbjct: 26 LDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQ--TDQSQTDEMLEEATNMFRLRHD 83 Query: 66 NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 125 N++K+ ++ + P G+L L+ G E ++ + GM + Sbjct: 84 NLLKIIGFC--MHDDGLKIVTIYRPLGNLQNFLKLHKENLGAREQ--VLYCYQIASGMQY 139 Query: 126 LRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTE---EYLHP 182 L + +VHRD+ N++ + ++TDFG ++ L+ D +++ + ++L Sbjct: 140 LEKQRVVHRDLATRNVLV----KKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAI 195 Query: 183 DMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVMYKIITGK 241 +++ + Y D+W+ GVT + T G P++ + + + Sbjct: 196 EIFSKHC--------YTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQ 247 Query: 242 PSGAISGV-QKAENGPIDWSGDMPVSCSLSRGLQV 275 P + Q+ + P L + Sbjct: 248 PPNCSQDLYQELLRCWMADPKSRPGFEILYERFKE 282 >6GVJ-A nrPDB Length = 429 Score = 163 bits (412), Expect = 3e-40, Method: Composition-based stats. Identities = 55/229 (24%), Positives = 107/229 (46%), Gaps = 21/229 (9%) Query: 3 STSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFN-NISFLRPVDVQMREFEVLKK 61 S ++ + +G G ++ VF+ + + ++AIK N + + +D E L K Sbjct: 140 SVKGRIYSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNK 198 Query: 62 L--NHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDV 119 L + I++L+ E T ++ ++ME C L + L++ + + E +++ Sbjct: 199 LQQHSDKIIRLYDY--EITDQYIYMVME-CGNIDLNSWLKKKKS---IDPWERKSYWKNM 252 Query: 120 VGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFV---SLYGT 176 + ++ + ++GIVH D+KP N + V + KL DFG A +++ D V S GT Sbjct: 253 LEAVHTIHQHGIVHSDLKPANFLIV-----DGMLKLIDFGIANQMQPDTTSVVKDSQVGT 307 Query: 177 EEYLHPDMYERAVLRKDHQKKYGATV---DLWSIGVTFYHAATGSLPFR 222 Y+ P+ + +++ K D+WS+G Y+ G PF+ Sbjct: 308 VNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ 356 >5USZ-A nrPDB Length = 289 Score = 162 bits (410), Expect = 5e-40, Method: Composition-based stats. Identities = 63/294 (21%), Positives = 117/294 (39%), Gaps = 30/294 (10%) Query: 1 MQSTSNHLWLLSDILGQGATANVFRGRHKKTGD-------LFAIKVFNNISFLRPVDVQM 53 N + ++ LGQG +F+G ++ GD +KV + + + Sbjct: 2 FHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDK-AHRNYSESFF 60 Query: 54 REFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFL 113 ++ KL+HK++V + + +L+ EF GSL T L++ N + L Sbjct: 61 EAASMMSKLSHKHLVLNYGVCVCGD--ENILVQEFVKFGSLDTYLKKNKNCINILWK--L 116 Query: 114 IVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQ----SVYKLTDFGAARELEDDEQ 169 V + + M+ L EN ++H ++ NI+ + ED + KL+D G + + + Sbjct: 117 EVAKQLAAAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDI 176 Query: 170 FVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPR 228 ++ P+ E + K D WS G T + + G P + R Sbjct: 177 LQERI---PWVPPECIE-------NPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQR 226 Query: 229 RNKEVMYKIITGKPSGAISGVQKAENGPIDWSGD-MPVSCSLSRGLQVLLTPVL 281 + + Y+ P+ + + N +D+ D P ++ R L L TP L Sbjct: 227 KLQ--FYEDRHQLPAPKAAELANLINNCMDYEPDHRPSFRAIIRDLNSLFTPDL 278 >4CRL-A nrPDB Length = 406 Score = 162 bits (409), Expect = 6e-40, Method: Composition-based stats. Identities = 61/313 (19%), Positives = 122/313 (38%), Gaps = 41/313 (13%) Query: 15 LGQGATANVFRGRHKKTGDL--FAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFA 72 +G+G +V++ + K D +A+K RE +L++L H N++ L Sbjct: 30 VGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGISMS---ACREIALLRELKHPNVISLQK 86 Query: 73 IEEETTTRHKVLIMEFCPCGSLYTVLE------EPSNAYGLPESEFLIVLRDVVGGMNHL 126 + R L+ ++ L+ +++ LP +L ++ G+++L Sbjct: 87 VFLSHADRKVWLLFDYAEH-DLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHYL 145 Query: 127 RENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARE----LEDDEQFVSLYGTEEYLHP 182 N ++HRD+KP NI+ + + K+ D G AR L+ + T Y P Sbjct: 146 HANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAP 205 Query: 183 DMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRR-----NKEVMYKI 237 ++ A + Y +D+W+IG F T F + + + + + +I Sbjct: 206 ELLLGA-------RHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRI 258 Query: 238 --ITGKPSGA----ISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTP-------VLANI 284 + G P+ I + + D+ + +CSL + ++ +L + Sbjct: 259 FNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKL 318 Query: 285 LEADQEKCWGFDQ 297 L D K +Q Sbjct: 319 LTMDPIKRITSEQ 331 >6J5U-C nrPDB Length = 426 Score = 161 bits (407), Expect = 1e-39, Method: Composition-based stats. Identities = 57/220 (25%), Positives = 85/220 (38%), Gaps = 30/220 (13%) Query: 14 ILGQGATANVFRGRHKKT---------GDLFAIKVFNNISFLRPVDVQMREFEVLKKLNH 64 +LG+G VF+G +T G + A+K F + + E L +L+H Sbjct: 91 LLGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQLKPEGFQGHKE-WLTEVNYLGQLSH 149 Query: 65 KNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 124 N+V L E R +L+ EF P GSL L A L + + V G+ Sbjct: 150 PNLVLLVGYCAEGENR--LLVYEFMPKGSLENHLFRRG-AQPLTWAIRMKVAVGAAKGLT 206 Query: 125 HLRENG--IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQF---VSLYGTEEY 179 L E +++RD K NI+ D KL+DFG A+ + + GT Y Sbjct: 207 FLHEAKSQVIYRDFKAANILL----DADFNAKLSDFGLAKAGPTGDNTHVSTKVIGTHGY 262 Query: 180 LHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSL 219 P+ L A D++S GV +G Sbjct: 263 AAPEYVATGRL--------TAKSDVYSFGVVLLELISGRR 294 >3LMG-A nrPDB Length = 344 Score = 161 bits (407), Expect = 1e-39, Method: Composition-based stats. Identities = 54/219 (24%), Positives = 88/219 (40%), Gaps = 23/219 (10%) Query: 13 DILGQGATANVFRGRHKKTGD----LFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIV 68 +LG G V +G G+ IKV + S + + L+H +IV Sbjct: 37 KVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIV 96 Query: 69 KLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE 128 +L + ++ L+ ++ P GSL + + A L L + GM +L E Sbjct: 97 RLLGLCPGSS---LQLVTQYLPLGSLLDHVRQHRGA--LGPQLLLNWGVQIAKGMYYLEE 151 Query: 129 NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQ--FVSLYGTEEYLHPDMYE 186 +G+VHR++ N++ S ++ DFG A L D++ S T + Sbjct: 152 HGMVHRNLAARNVLL----KSPSQVQVADFGVADLLPPDDKQLLYSEAKTP-------IK 200 Query: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPF 224 L H KY D+WS GVT + T G+ P+ Sbjct: 201 WMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGL 239 >5TUR-A nrPDB Length = 404 Score = 160 bits (406), Expect = 1e-39, Method: Composition-based stats. Identities = 59/288 (20%), Positives = 102/288 (35%), Gaps = 36/288 (12%) Query: 6 NHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVD-----VQMREFEVLK 60 + + +LG G +V+ G AIK + E +LK Sbjct: 126 ESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLK 185 Query: 61 KLNHKN--IVKLFAIEEETTTRHKVLIME-FCPCGSLYTVLEEPSNAYGLPESEFLIVLR 117 K++ +++L E + VLI+E P L+ + E L E Sbjct: 186 KVSSGFSGVIRLLDWFERPDS--FVLILERPEPVQDLFDFITERG---ALQEELARSFFW 240 Query: 118 DVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTE 177 V+ + H G++HRDIK NI+ + + KL DFG + L D + GT Sbjct: 241 QVLEAVRHCHNCGVLHRDIKDENILIDLN---RGELKLIDFG-SGALLKDTVYTDFDGTR 296 Query: 178 EYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKI 237 Y P+ + + +G + +WS+G+ Y G +PF E R + + Sbjct: 297 VYSPPEWIR-------YHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQR 349 Query: 238 ITGKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANIL 285 ++ + I P +Q P + ++L Sbjct: 350 VSSECQHLIRWCLAL----------RPSDRPTFEEIQN--HPWMQDVL 385 >3HMP-A nrPDB Length = 342 Score = 160 bits (405), Expect = 2e-39, Method: Composition-based stats. Identities = 55/229 (24%), Positives = 107/229 (46%), Gaps = 21/229 (9%) Query: 3 STSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFN-NISFLRPVDVQMREFEVLKK 61 S ++ + +G G ++ VF+ + + ++AIK N + + +D E L K Sbjct: 52 SVKGRIYSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNK 110 Query: 62 L--NHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDV 119 L + I++L+ E T ++ ++ME C L + L++ + + E +++ Sbjct: 111 LQQHSDKIIRLYDY--EITDQYIYMVME-CGNIDLNSWLKKKKS---IDPWERKSYWKNM 164 Query: 120 VGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFV---SLYGT 176 + ++ + ++GIVH D+KP N + V + KL DFG A +++ D V S GT Sbjct: 165 LEAVHTIHQHGIVHSDLKPANFLIV-----DGMLKLIDFGIANQMQPDTTSVVKDSQVGT 219 Query: 177 EEYLHPDMYERAVLRKDHQKKYGATV---DLWSIGVTFYHAATGSLPFR 222 Y+ P+ + +++ K D+WS+G Y+ G PF+ Sbjct: 220 VNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ 268 >3UIM-A nrPDB Length = 326 Score = 160 bits (405), Expect = 2e-39, Method: Composition-based stats. Identities = 57/296 (19%), Positives = 111/296 (37%), Gaps = 29/296 (9%) Query: 12 SDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLF 71 +ILG+G V++GR G L A+K E E++ H+N+++L Sbjct: 35 KNILGRGGFGKVYKGRL-ADGTLVAVKRLKEERTQGGELQFQTEVEMISMAVHRNLLRLR 93 Query: 72 AIEEETTTRHKVLIMEFCPCGSLYTVLEE-PSNAYGLPESEFLIVLRDVVGGMNHLREN- 129 T R +L+ + GS+ + L E P + L + + G+ +L ++ Sbjct: 94 GFCMTPTER--LLVYPYMANGSVASCLRERPESQPPLDWPKRQRIALGSARGLAYLHDHC 151 Query: 130 --GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELE--DDEQFVSLYGTEEYLHPDMY 185 I+HRD+K NI+ D + + DFG A+ ++ D ++ GT ++ P+ Sbjct: 152 DPKIIHRDVKAANILL----DEEFEAVVGDFGLAKLMDYKDTHVTTAVRGTIGHIAPEYL 207 Query: 186 ERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGA 245 K D++ GV TG F + ++ + G Sbjct: 208 S--------TGKSSEKTDVFGYGVMLLELITGQRAFDLARLANDDDVMLLDWVKGLLKEK 259 Query: 246 ISGV-------QKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQ-EKCW 293 ++ ++ + + C+ S ++ + +LE D + W Sbjct: 260 KLEALVDVDLQGNYKDEEVEQLIQVALLCTQSSPMERPKMSEVVRMLEGDGLAERW 315 >3BGP-A nrPDB Length = 333 Score = 160 bits (405), Expect = 2e-39, Method: Composition-based stats. Identities = 59/288 (20%), Positives = 102/288 (35%), Gaps = 36/288 (12%) Query: 6 NHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVD-----VQMREFEVLK 60 + + +LG G +V+ G AIK + E +LK Sbjct: 55 ESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLK 114 Query: 61 KLNHKN--IVKLFAIEEETTTRHKVLIME-FCPCGSLYTVLEEPSNAYGLPESEFLIVLR 117 K++ +++L E + VLI+E P L+ + E L E Sbjct: 115 KVSSGFSGVIRLLDWFERPDS--FVLILERPEPVQDLFDFITERG---ALQEELARSFFW 169 Query: 118 DVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTE 177 V+ + H G++HRDIK NI+ + + KL DFG + L D + GT Sbjct: 170 QVLEAVRHCHNCGVLHRDIKDENILIDLN---RGELKLIDFG-SGALLKDTVYTDFDGTR 225 Query: 178 EYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKI 237 Y P+ + + +G + +WS+G+ Y G +PF E R + + Sbjct: 226 VYSPPEWIR-------YHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQR 278 Query: 238 ITGKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANIL 285 ++ + I P +Q P + ++L Sbjct: 279 VSSECQHLIRWCLAL----------RPSDRPTFEEIQN--HPWMQDVL 314 >4Y83-A nrPDB Length = 332 Score = 160 bits (404), Expect = 2e-39, Method: Composition-based stats. Identities = 67/278 (24%), Positives = 111/278 (39%), Gaps = 34/278 (12%) Query: 12 SDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLF 71 SD + +GA V+ + KT A K+ F +P D E+ H+NI +L+ Sbjct: 78 SDFIPRGAFGKVYLAQDIKTKKRMACKLIPVDQF-KPSD-----VEIQACFRHENIAELY 131 Query: 72 AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGI 131 T H L ME GS VLE+ + + E E + V + V+ G++ L + Sbjct: 132 GAVLWGETVH--LFMEAGEGGS---VLEKLESCGPMREFEIIWVTKHVLKGLDFLHSKKV 186 Query: 132 VHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQF-VSLYGTEEYLHPDMYERAVL 190 +H DIKP NI+ + L DFG + ++ +D F L GTE Y+ P++ Sbjct: 187 IHHDIKPSNIVF-----MSTKAVLVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVIL---- 237 Query: 191 RKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSG------ 244 + + D++S+G T H TG+ P+ +Y I P Sbjct: 238 ----CRGHSTKADIYSLGATLIHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIADD 293 Query: 245 AISGVQKAENGPIDWSG-DMPVSCSL--SRGLQVLLTP 279 G+++ ++ + P + L L Sbjct: 294 CSPGMRELIEASLERNPNHRPRAADLLKHEALNPPRED 331 >4LQP-A nrPDB Length = 508 Score = 159 bits (403), Expect = 3e-39, Method: Composition-based stats. Identities = 54/269 (20%), Positives = 86/269 (31%), Gaps = 71/269 (26%) Query: 12 SDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVD--VQMREFEVLKKLNHKNIVK 69 ++G+GA V + K TG ++A+K + E +VL + +V Sbjct: 107 VKVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKDQLAHVKAERDVLAGSDSPWVVS 166 Query: 70 LFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN 129 L+ ++ ++ LIMEF P G L T+L E + + + + + + Sbjct: 167 LYYSFQDA--QYLYLIMEFLPGGDLMTML---IRWQLFTEDVTRFYMAECILAIETIHKL 221 Query: 130 GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFV---------------SLY 174 G +HR IKP NI+ D + KL+DFG + S Sbjct: 222 GFIHRAIKPDNILI----DIRGHIKLSDFGLSTGFHKTHDSNYYKKLLQQDEATNGISKP 277 Query: 175 GT------------------------------------EEYLH------PDMYERAVLRK 192 GT + PD + Sbjct: 278 GTYNANTTDTANKRQTMVVDSISLTMSNRQQIQTWRKSRRLMAYSTVGTPDYIAPEIFL- 336 Query: 193 DHQKKYGATVDLWSIGVTFYHAATGSLPF 221 + YG D WS+G Y G PF Sbjct: 337 --YQGYGQECDWWSLGAIMYECLIGWPPF 363 >4RC3-A nrPDB Length = 289 Score = 159 bits (402), Expect = 4e-39, Method: Composition-based stats. Identities = 59/288 (20%), Positives = 102/288 (35%), Gaps = 36/288 (12%) Query: 6 NHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVD-----VQMREFEVLK 60 + + +LG G +V+ G AIK + E +LK Sbjct: 11 ESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLK 70 Query: 61 KLNHKN--IVKLFAIEEETTTRHKVLIME-FCPCGSLYTVLEEPSNAYGLPESEFLIVLR 117 K++ +++L E + VLI+E P L+ + E L E Sbjct: 71 KVSSGFSGVIRLLDWFERPDS--FVLILERPEPVQDLFDFITERG---ALQEELARSFFW 125 Query: 118 DVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTE 177 V+ + H G++HRDIK NI+ + + KL DFG + L D + GT Sbjct: 126 QVLEAVRHCHNCGVLHRDIKDENILIDLN---RGELKLIDFG-SGALLKDTVYTDFDGTR 181 Query: 178 EYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKI 237 Y P+ + + +G + +WS+G+ Y G +PF E R + + Sbjct: 182 VYSPPEWIR-------YHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQR 234 Query: 238 ITGKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANIL 285 ++ + I P +Q P + ++L Sbjct: 235 VSSECQHLIRWCLAL----------RPSDRPTFEEIQN--HPWMQDVL 270 >5AP3-A nrPDB Length = 313 Score = 158 bits (401), Expect = 6e-39, Method: Composition-based stats. Identities = 57/233 (24%), Positives = 108/233 (46%), Gaps = 23/233 (9%) Query: 1 MQSTS--NHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFN-NISFLRPVDVQMREFE 57 QS S ++ + +G G ++ VF+ + + ++AIK N + + +D E Sbjct: 20 FQSMSVKGRIYSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRNEIA 78 Query: 58 VLKKL--NHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIV 115 L KL + I++L+ E T ++ ++ME C L L++ + + E Sbjct: 79 YLNKLQQHSDKIIRLYDY--EITDQYIYMVME-CGNIDLNGWLKKKKS---IDPWERKSY 132 Query: 116 LRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFV---S 172 ++++ ++ + ++GIVH D+KP N + V + KL DFG A +++ D V S Sbjct: 133 WKNMLEAVHTIHQHGIVHSDLKPANFLIV-----DGMLKLIDFGIANQMQPDTTSVVKDS 187 Query: 173 LYGTEEYLHPDMYERAVLRKDHQKKYGATV---DLWSIGVTFYHAATGSLPFR 222 GT Y+ P+ + +++ K D+WS+G Y+ G PF+ Sbjct: 188 QVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ 240 >2ZMD-A nrPDB Length = 390 Score = 158 bits (400), Expect = 7e-39, Method: Composition-based stats. Identities = 62/313 (19%), Positives = 128/313 (40%), Gaps = 44/313 (14%) Query: 3 STSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFN-NISFLRPVDVQMREFEVLKK 61 S ++ + +G G ++ VF+ + + ++AIK N + + +D E L K Sbjct: 52 SVKGRIYSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNK 110 Query: 62 L--NHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDV 119 L + I++L+ E T ++ ++ME C L + L++ + + E +++ Sbjct: 111 LQQHSDKIIRLYDY--EITDQYIYMVME-CGNIDLNSWLKKKKS---IDPWERKSYWKNM 164 Query: 120 VGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFV---SLYGT 176 + ++ + ++GIVH D+KP N + V + KL DFG A +++ D V S G Sbjct: 165 LEAVHTIHQHGIVHSDLKPANFLIV-----DGMLKLIDFGIANQMQPDTTSVVKDSQVGA 219 Query: 177 EEYLHPDMYERAVLRKDHQKKYGATV---DLWSIGVTFYHAATGSLPFR----------- 222 Y+ P+ + +++ K D+WS+G Y+ G PF+ Sbjct: 220 VNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHA 279 Query: 223 ----------PFEGPRRNKEVMYKIITGKPSGAISGVQKAENGPIDWSGDMPVSCSLSRG 272 P + ++V+ + P IS + + + +++G Sbjct: 280 IIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQTH--PVNQMAKG 337 Query: 273 LQVLLTPVLANIL 285 + VL ++ Sbjct: 338 TTEEMKYVLGQLV 350 >2BUJ-A nrPDB Length = 317 Score = 157 bits (398), Expect = 1e-38, Method: Composition-based stats. Identities = 64/296 (21%), Positives = 110/296 (37%), Gaps = 26/296 (8%) Query: 1 MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLK 60 M N +L LG+G + V G +A+K + + RE ++ + Sbjct: 23 MVIIDNKHYLFIQKLGEGGFSYVDLVEGLHDGHFYALKRI-LCHEQQDREEAQREADMHR 81 Query: 61 KLNHKNIVKLFAIE--EETTTRHKVLIMEFCPCGSLYTVLEE-PSNAYGLPESEFLIVLR 117 NH NI++L A E L++ F G+L+ +E L E + L +L Sbjct: 82 LFNHPNILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFLTEDQILWLLL 141 Query: 118 DVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGA----------ARELEDD 167 + G+ + G HRD+KP NI+ G++GQ V L D G+ +R+ Sbjct: 142 GICRGLEAIHAKGYAHRDLKPTNILL--GDEGQPV--LMDLGSMNQACIHVEGSRQALTL 197 Query: 168 EQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRP--FE 225 + + + T Y P+++ D+WS+G Y G P+ + Sbjct: 198 QDWAAQRCTISYRAPELFS-----VQSHCVIDERTDVWSLGCVLYAMMFGEGPYDMVFQK 252 Query: 226 GPRRNKEVMYKIITGKPSGAISGVQKAENGPIDWSGD-MPVSCSLSRGLQVLLTPV 280 G V ++ + S + + N + P L L+ L P Sbjct: 253 GDSVALAVQNQLSIPQSPRHSSALWQLLNSMMTVDPHQRPHIPLLLSQLEALQPPA 308 >4NEU-A nrPDB Length = 333 Score = 157 bits (398), Expect = 1e-38, Method: Composition-based stats. Identities = 58/307 (18%), Positives = 108/307 (35%), Gaps = 40/307 (13%) Query: 4 TSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLN 63 + +L S L G V H+ G + V+ + + + + E +++ +L Sbjct: 21 MKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLR 80 Query: 64 HKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 123 H +VKL + E L+ME+ G+L VL+ + P S ++ +++ GM Sbjct: 81 HSRVVKLLGVIIEEGKY--SLVMEYMEKGNLMHVLKAEMST---PLSVKGRIILEIIEGM 135 Query: 124 NHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAAREL--------------EDDEQ 169 +L G++H+D+KP NI+ D K+ D G A E D Sbjct: 136 CYLHGKGVIHKDLKPENILV----DNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGT 191 Query: 170 FVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRR 229 GT Y+ P+ D K D++S V + P+ E Sbjct: 192 AKKNGGTLYYMAPEHLN------DVNAKPTEKSDVYSFAVVLWAIFANKEPY---ENAIC 242 Query: 230 NKEVMYKIITGKPS-------GAISGVQKAENGPIDWSGD-MPVSCSLSRGLQVLLTPVL 281 ++++ I +G + + + + P + + L Sbjct: 243 EQQLIMCIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQL 302 Query: 282 ANILEAD 288 +E D Sbjct: 303 EESVEED 309 >4C59-A nrPDB Length = 340 Score = 157 bits (397), Expect = 2e-38, Method: Composition-based stats. Identities = 50/234 (21%), Positives = 89/234 (38%), Gaps = 33/234 (14%) Query: 11 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLN-HKNIVK 69 + +L +G A V+ + +G +A+K + + ++E +KKL+ H NIV+ Sbjct: 31 VRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNR-AIIQEVCFMKKLSGHPNIVQ 89 Query: 70 L-----FAIEEETTTR-HKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 123 EE T + +L+ E C G L L++ + L L + + Sbjct: 90 FCSAASIGKEESDTGQAEFLLLTELCK-GQLVEFLKKMESRGPLSCDTVLKIFYQTCRAV 148 Query: 124 NHLRENG--IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQF----------- 170 H+ I+HRD+K N++ Q KL DFG+A + + Sbjct: 149 QHMHRQKPPIIHRDLKVENLLLS----NQGTIKLCDFGSATTISHYPDYSWSAQRRALVE 204 Query: 171 --VSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFR 222 ++ T Y P++ + G D+W++G Y PF Sbjct: 205 EEITRNTTPMYRTPEIID-----LYSNFPIGEKQDIWALGCILYLLCFRQHPFE 253 >3LLT-A nrPDB Length = 360 Score = 155 bits (393), Expect = 4e-38, Method: Composition-based stats. Identities = 70/339 (20%), Positives = 116/339 (34%), Gaps = 61/339 (17%) Query: 6 NHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHK 65 N+ +L+ +G G V +H +A+KV NI + E ++LKK+ + Sbjct: 34 NNAFLVIRKMGDGTFGRVLLCQHIDNKKYYAVKVVRNIK--KYTRSAKIEADILKKIQND 91 Query: 66 NI-----VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVV 120 +I VK H LI E SLY ++ N G + + +++ Sbjct: 92 DINNNNIVKYHGKFMYYD--HMCLIFEPL-GPSLYEIITRN-NYNGFHIEDIKLYCIEIL 147 Query: 121 GGMNHLRENGIVHRDIKPGNIMR---------------------VIGEDGQSVYKLTDFG 159 +N+LR+ + H D+KP NI+ I + KL DFG Sbjct: 148 KALNYLRKMSLTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTKSTGIKLIDFG 207 Query: 160 AARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSL 219 A + S+ T +Y P++ + + D+WS G TGSL Sbjct: 208 CATF--KSDYHGSIINTRQYRAPEVILNL--------GWDVSSDMWSFGCVLAELYTGSL 257 Query: 220 PFRPFEGPRRNKEVMYKIITGKPSGAISGVQK--------AENGPIDWSGDMPVSCSLSR 271 FR E + +M II P + K + + W + S+ Sbjct: 258 LFRTHEH-MEHLAMMESIIQPIPKNMLYEATKTNGSKYVNKDELKLAWPENASSINSIKH 316 Query: 272 GLQ----------VLLTPVLANILEADQEKCWGFDQFFA 300 + L L +IL+ D + Sbjct: 317 VKKCLPLYKIIKHELFCDFLYSILQIDPTLRPSPAELLK 355 >5IKW-A nrPDB Length = 310 Score = 155 bits (391), Expect = 7e-38, Method: Composition-based stats. Identities = 58/234 (24%), Positives = 97/234 (41%), Gaps = 27/234 (11%) Query: 3 STSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKL 62 + H L + L +G + VF R G A+K ++ + ++V RE ++K+L Sbjct: 10 AVGRHQVTLEESLAEGGFSTVFLVR-THGGIRCALKRM-YVNNMPDLNVCKREITIMKEL 67 Query: 63 N-HKNIVKLFAIEEETTTRHKV---LIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRD 118 + HKNIV + + + ++ME+C G + + + G E E L + D Sbjct: 68 SGHKNIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQT-GFTEPEVLQIFCD 126 Query: 119 VVGGMNHLRENG--IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARE---------LEDD 167 + L + I+HRD+K NI+ DG + L DFG+A + Sbjct: 127 TCEAVARLHQCKTPIIHRDLKVENILL---NDGGNYV-LCDFGSATNKFLNPQKDGVNVV 182 Query: 168 EQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 E+ + Y T Y P+M K D+W++G Y +LPF Sbjct: 183 EEEIKKYTTLSYRAPEMI-----NLYGGKPITTKADIWALGCLLYKLCFFTLPF 231 >2RIO-A nrPDB Length = 434 Score = 154 bits (389), Expect = 1e-37, Method: Composition-based stats. Identities = 55/242 (22%), Positives = 108/242 (44%), Gaps = 31/242 (12%) Query: 1 MQSTSNHLWLLSDILGQGATANV-FRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVL 59 + + +L + ILG G++ V F+G + G A+K + D+ + E ++L Sbjct: 9 FEQSLKNLVVSEKILGYGSSGTVVFQGSFQ--GRPVAVKRM----LIDFCDIALMEIKLL 62 Query: 60 KKLN-HKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEP----SNAYGLPESEFLI 114 + + H N+++ + ETT R + +E C +L ++E N E + Sbjct: 63 TESDDHPNVIRYY--CSETTDRFLYIALELCNL-NLQDLVESKNVSDENLKLQKEYNPIS 119 Query: 115 VLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGED---------GQSVYKLTDFGAARELE 165 +LR + G+ HL I+HRD+KP NI+ ++DFG ++L+ Sbjct: 120 LLRQIASGVAHLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLD 179 Query: 166 DDE-----QFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSL 219 + + GT + P++ E + +++ ++D++S+G FY+ + G Sbjct: 180 SGQSSFRTNLNNPSGTSGWRAPELLEESN-NLQTKRRLTRSIDIFSMGCVFYYILSKGKH 238 Query: 220 PF 221 PF Sbjct: 239 PF 240 >2JD5-A nrPDB Length = 373 Score = 153 bits (386), Expect = 3e-37, Method: Composition-based stats. Identities = 53/261 (20%), Positives = 102/261 (39%), Gaps = 31/261 (11%) Query: 5 SNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNH 64 + ++L LG G + V+ + A+K+ + E ++L+++N Sbjct: 17 KDARYILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVRGDKVY--TEAAEDEIKLLQRVND 74 Query: 65 K-----------NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFL 113 +I+KL ++M F G L + G+P Sbjct: 75 ADNTKEDSMGANHILKLLDHFNHKGPNGVHVVMVFEVLGENLLALIKKYEHRGIPLIYVK 134 Query: 114 IVLRDVVGGMNHLREN-GIVHRDIKPGNIMRVIGEDGQSV--YKLTDFGAARELEDDEQF 170 + + ++ G++++ GI+H DIKP N++ I + +++ K+ D G A DE + Sbjct: 135 QISKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNACWY--DEHY 192 Query: 171 VSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRN 230 + T EY P++ A +G D+WS + TG F P EG Sbjct: 193 TNSIQTREYRSPEVLLGA--------PWGCGADIWSTACLIFELITGDFLFEPDEGHSYT 244 Query: 231 KE-----VMYKIITGKPSGAI 246 K+ + +++ PS + Sbjct: 245 KDDDHIAQIIELLGELPSYLL 265 >2Y4I-B nrPDB Length = 319 Score = 152 bits (385), Expect = 4e-37, Method: Composition-based stats. Identities = 54/281 (19%), Positives = 117/281 (41%), Gaps = 30/281 (10%) Query: 10 LLSDILGQGATANVFRGRHKKTGDLFAIKVFN-NISFLRPVDVQMREFEVLKKLNHKNIV 68 + +++G+G V+ GR AI++ + + RE ++ H+N+V Sbjct: 36 EIGELIGKGRFGQVYHGRWHG---EVAIRLIDIERDNEDQLKAFKREVMAYRQTRHENVV 92 Query: 69 KLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE 128 + H +I C +LY+V+ + L ++ + +++V GM +L Sbjct: 93 LFMGAC--MSPPHLAIITSLCKGRTLYSVVRDAK--IVLDVNKTRQIAQEIVKGMGYLHA 148 Query: 129 NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGA---ARELEDD---EQFVSLYGTEEYLHP 182 GI+H+D+K N+ G+ +TDFG + L+ ++ G +L P Sbjct: 149 KGILHKDLKSKNVFYDNGK-----VVITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAP 203 Query: 183 DMYERAVLRKDHQK-KYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITG- 240 ++ + + K + D++++G +Y PF+ + +++++ TG Sbjct: 204 EIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPA----EAIIWQMGTGM 259 Query: 241 KPSGAISGVQKAENGPIDW-----SGDMPVSCSLSRGLQVL 276 KP+ + G+ K + + + + P L L+ L Sbjct: 260 KPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLEKL 300 >1PY5-A nrPDB Length = 326 Score = 152 bits (385), Expect = 4e-37, Method: Composition-based stats. Identities = 56/265 (21%), Positives = 106/265 (40%), Gaps = 43/265 (16%) Query: 1 MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLK 60 +Q T +L + +G+G V+RG+ + G+ A+K+F++ R RE E+ + Sbjct: 23 VQRTIARTIVLQESIGKGRFGEVWRGKWR--GEEVAVKIFSS----REERSWFREAEIYQ 76 Query: 61 --KLNHKNIVKLFAIE--EETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVL 116 L H+NI+ A + + T L+ ++ GSL+ L N Y + + + Sbjct: 77 TVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYL----NRYTVTVEGMIKLA 132 Query: 117 RDVVGGMNHLR--------ENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDE 168 G+ HL + I HRD+K NI+ + D G A + Sbjct: 133 LSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILV----KKNGTCCIADLGLAVRHDSAT 188 Query: 169 QF-----VSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATG------ 217 GT+ Y+ P++ + ++ K + D++++G+ F+ A Sbjct: 189 DTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESF--KRADIYAMGLVFWEIARRCSIGGI 246 Query: 218 ----SLPFRPFEGPRRNKEVMYKII 238 LP+ + E M K++ Sbjct: 247 HEDYQLPYYDLVPSDPSVEEMRKVV 271 >5X18-A nrPDB Length = 295 Score = 152 bits (385), Expect = 4e-37, Method: Composition-based stats. Identities = 66/303 (21%), Positives = 121/303 (39%), Gaps = 37/303 (12%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNH-KNI 67 + + +G+G+ +F G + G AIK E++ K LN NI Sbjct: 9 YKIGKKIGEGSFGVLFEGTNMINGVPVAIKF---EPRKTEAPQLRDEYKTYKILNGTPNI 65 Query: 68 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 127 +A H +L+++ SL + + + V ++ + L Sbjct: 66 P--YAYYFGQEGLHNILVIDLL-GPSLEDLFD--WCGRKFSVKTVVQVAVQMITLIEDLH 120 Query: 128 ENGIVHRDIKPGNIMR-VIGEDGQSVYKLTDFGAARELEDDE--------QFVSLYGTEE 178 + +++RDIKP N + G+ + L DFG A++ D + + SL GT Sbjct: 121 AHDLIYRDIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRDPKTKQHIPYREKKSLSGTAR 180 Query: 179 YLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKII 238 Y+ + ++ D+ ++G F++ G LP++ + P NK+ KI Sbjct: 181 YMS--------INTHLGREQSRRDDMEALGHVFFYFLRGHLPWQGLKAP-NNKQKYEKIG 231 Query: 239 TGKPSGAISGVQKAENGPIDWSGDMPVSCSLS-------RGLQVLLTPVLANILE-ADQE 290 K S + + A+ P+ + + + SLS G + LL VL ++ E AD + Sbjct: 232 EKKRSTNVYDL--AQGLPVQFGRYLEIVRSLSFEECPDYEGYRKLLLSVLDDLGETADGQ 289 Query: 291 KCW 293 W Sbjct: 290 YDW 292 >5WNL-A nrPDB Length = 342 Score = 152 bits (384), Expect = 6e-37, Method: Composition-based stats. Identities = 71/375 (18%), Positives = 130/375 (34%), Gaps = 59/375 (15%) Query: 1 MQSTSNHLWLLS-------------DILGQGATANVFRGRHKKTGDLFAIKV-FNNISFL 46 M+ W L + +G G V++ RH AIK + Sbjct: 1 MEGEGRGRWALGLLRTFDAGEFAGWEKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDD 60 Query: 47 RPVDVQMREFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYG 106 R + E + ++ + I+ ++ I +E L+ME+ GSL +L + Sbjct: 61 RERMELLEEAKKMEMAKFRYILPVYGICQEPVG----LVMEYMETGSLEKLL----ASEP 112 Query: 107 LPESEFLIVLRDVVGGMNHLR--ENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAAR-- 162 LP ++ + GMN L ++H ++KP NI+ D K++DFG A+ Sbjct: 113 LPWDLRFRIVHETAVGMNFLHCMSPPLLHLNLKPANILL----DAHYHVKISDFGLAKCN 168 Query: 163 --ELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLP 220 D L+GT YL P+ ++ + + D++S + + T P Sbjct: 169 GMSHSHDLSMDGLFGTIAYLPPERI------REKSRLFDTKHDVYSFAIVIWGVLTQKKP 222 Query: 221 FRPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPV 280 F + +M K++ G P+ R L+ + Sbjct: 223 FA---DEKNILHIMMKVVKGHRPELP-----------------PICRPRPRACASLI-GL 261 Query: 281 LANILEADQEKCWGFDQFFAETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVY 340 + AD + F + +ET D+ + V L K + S + A + Sbjct: 262 MQRCWHADPQVRPTFQEITSETEDLCEKPDEEVKDLAHEPGEKSSLESKSEARPESSRLK 321 Query: 341 KQTKIISSNQELIYE 355 + + N + E Sbjct: 322 RASAPPFDNDCSLSE 336 >5TE0-A nrPDB Length = 347 Score = 152 bits (384), Expect = 6e-37, Method: Composition-based stats. Identities = 55/235 (23%), Positives = 92/235 (39%), Gaps = 28/235 (11%) Query: 3 STSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKL 62 + ++L +G A VF R G A+K ++ + V RE ++++ L Sbjct: 15 GIGRQQVTVDEVLAEGGFAIVFLVR-TSNGMKCALKRM-FVNNEHDLQVCKREIQIMRDL 72 Query: 63 N-HKNIVKLFAI----EEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLR 117 + HKNIV +++M+FC G + ++ + G E+E L + Sbjct: 73 SGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQT-GFTENEVLQIFC 131 Query: 118 DVVGGMNHLRENG--IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARE---------LED 166 D + L + I+HRD+K NI+ + Y L DFG+A + Sbjct: 132 DTCEAVARLHQCKTPIIHRDLKVENILL----HDRGHYVLCDFGSATNKFQNPQTEGVNA 187 Query: 167 DEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 E + Y T Y P+M K D+W++G Y +LPF Sbjct: 188 VEDEIKKYTTLSYRAPEMV-----NLYSGKIITTKADIWALGCLLYKLCYFTLPF 237 >2QKW-B nrPDB Length = 321 Score = 151 bits (382), Expect = 1e-36, Method: Composition-based stats. Identities = 47/207 (22%), Positives = 84/207 (40%), Gaps = 20/207 (9%) Query: 14 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAI 73 ++G G V++G + G A+K + ++ E E L H ++V L Sbjct: 46 LIGHGVFGKVYKGVLR-DGAKVALKR-RTPESSQGIEEFETEIETLSFCRHPHLVSLIGF 103 Query: 74 EEETTTRHKVLIMEFCPCGSLYTVLEEPS-NAYGLPESEFLIVLRDVVGGMNHLRENGIV 132 +E +LI ++ G+L L + + L + G+++L I+ Sbjct: 104 CDERN--EMILIYKYMENGNLKRHLYGSDLPTMSMSWEQRLEICIGAARGLHYLHTRAII 161 Query: 133 HRDIKPGNIMRVIGEDGQSVYKLTDFGAAR---ELEDDEQFVSLYGTEEYLHPDMYERAV 189 HRD+K NI+ D V K+TDFG ++ EL+ + GT Y+ P+ + + Sbjct: 162 HRDVKSINILL----DENFVPKITDFGISKKGTELDQTHLSTVVKGTLGYIDPEYFIKGR 217 Query: 190 LRKDHQKKYGATVDLWSIGVTFYHAAT 216 L D++S GV + Sbjct: 218 L--------TEKSDVYSFGVVLFEVLC 236 >4PL5-B nrPDB Length = 435 Score = 150 bits (379), Expect = 2e-36, Method: Composition-based stats. Identities = 58/218 (26%), Positives = 98/218 (44%), Gaps = 24/218 (11%) Query: 12 SDILGQGATAN-VFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLN-HKNIVK 69 D+LG GA V++G A+K F RE ++L++ + H N+++ Sbjct: 32 KDVLGHGAEGTIVYKGMF--DNRDVAVKRILPECF----SFADREVQLLRESDEHPNVIR 85 Query: 70 LFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN 129 F E + + + +E C +L +E+ A+ E + +L G+ HL Sbjct: 86 YF--CTEKDRQFQYIAIELCAA-TLQEYVEQKDFAHLGLEP--ITLLHQTTSGLAHLHSL 140 Query: 130 GIVHRDIKPGNIMRVI-GEDGQSVYKLTDFGAARELEDDEQFVSLY----GTEEYLHPDM 184 IVHRD+KP NI+ + G+ ++DFG ++L S GTE ++ P+M Sbjct: 141 NIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEM 200 Query: 185 YERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPF 221 +D + TVD++S G FY+ + G PF Sbjct: 201 LS-----EDCKDNPTYTVDIFSAGCVFYYVISEGYHPF 233 >3MY0-A nrPDB Length = 305 Score = 150 bits (378), Expect = 2e-36, Method: Composition-based stats. Identities = 58/265 (21%), Positives = 96/265 (36%), Gaps = 43/265 (16%) Query: 1 MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLK 60 MQ T L + +G+G V+RG G+ A+K+F++ R RE E+ Sbjct: 2 MQRTVARQVALVECVGKGRYGEVWRGLWH--GESVAVKIFSS----RDEQSWFRETEIYN 55 Query: 61 --KLNHKNIVKLF--AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVL 116 L H NI+ + ++ LI + GSLY L+ L L + Sbjct: 56 TVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQR----QTLEPHLALRLA 111 Query: 117 RDVVGGMNHLR--------ENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDE 168 G+ HL + I HRD K N++ + D G A Sbjct: 112 VSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLV----KSNLQCCIADLGLAVMHSQGS 167 Query: 169 QFVS-----LYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATG------ 217 ++ GT+ Y+ P++ + +R D + Y D+W+ G+ + A Sbjct: 168 DYLDIGNNPRVGTKRYMAPEVLD-EQIRTDCFESY-KWTDIWAFGLVLWEIARRTIVNGI 225 Query: 218 ----SLPFRPFEGPRRNKEVMYKII 238 PF + E M K++ Sbjct: 226 VEDYRPPFYDVVPNDPSFEDMKKVV 250 >4IAN-A nrPDB Length = 358 Score = 150 bits (378), Expect = 3e-36, Method: Composition-based stats. Identities = 56/215 (26%), Positives = 93/215 (43%), Gaps = 24/215 (11%) Query: 16 GQGATANVFRGRHK-KTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHK------NIV 68 GQG +NV R R + A+K+ N ++ ++E E LKKLN + + Sbjct: 39 GQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTG--LKELEFLKKLNDADPDDKFHCL 96 Query: 69 KLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE 128 +LF +H L+ E +L VL++ GL + + + L+ Sbjct: 97 RLF--RHFYHKQHLCLVFEPLSM-NLREVLKKYGKDVGLHIKAVRSYSQQLFLALKLLKR 153 Query: 129 NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERA 188 I+H DIKP NI+ + +++ KL DFG+A + D++ + Y P++ Sbjct: 154 CNILHADIKPDNILV---NESKTILKLCDFGSASHVADND-ITPYLVSRFYRAPEIIIG- 208 Query: 189 VLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRP 223 K Y +D+WS+G T Y TG + F Sbjct: 209 -------KSYDYGIDMWSVGCTLYELYTGKILFPG 236 >6HV0-A nrPDB Length = 416 Score = 149 bits (377), Expect = 4e-36, Method: Composition-based stats. Identities = 60/218 (27%), Positives = 101/218 (46%), Gaps = 24/218 (11%) Query: 12 SDILGQGATAN-VFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLN-HKNIVK 69 D+LG GA V+RG A+K F RE ++L++ + H N+++ Sbjct: 13 KDVLGHGAEGTIVYRGMF--DNRDVAVKRILPECF----SFADREVQLLRESDEHPNVIR 66 Query: 70 LFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN 129 F E + + + +E C +L +E+ A+ E + +L+ G+ HL Sbjct: 67 YF--CTEKDRQFQYIAIELCAA-TLQEYVEQKDFAHLGLEP--ITLLQQTTSGLAHLHSL 121 Query: 130 GIVHRDIKPGNIMRVI-GEDGQSVYKLTDFGAARELEDDEQFVSLY----GTEEYLHPDM 184 IVHRD+KP NI+ + G+ ++DFG ++L S GTE ++ P+M Sbjct: 122 NIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEM 181 Query: 185 YERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPF 221 +D ++ TVD++S G FY+ + GS PF Sbjct: 182 LS-----EDCKENPTYTVDIFSAGCVFYYVISEGSHPF 214 >3MDY-A nrPDB Length = 337 Score = 147 bits (372), Expect = 1e-35, Method: Composition-based stats. Identities = 59/265 (22%), Positives = 104/265 (39%), Gaps = 43/265 (16%) Query: 1 MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLK 60 +Q T + +G+G V+ G+ + G+ A+KVF F RE E+ + Sbjct: 31 VQRTIAKQIQMVKQIGKGRYGEVWMGKWR--GEKVAVKVF----FTTEEASWFRETEIYQ 84 Query: 61 --KLNHKNIVKLF--AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVL 116 + H+NI+ I+ + LI ++ GSLY L+ + L L + Sbjct: 85 TVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLK----STTLDAKSMLKLA 140 Query: 117 RDVVGGMNHLR--------ENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDE 168 V G+ HL + I HRD+K NI+ + D G A + D Sbjct: 141 YSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILV----KKNGTCCIADLGLAVKFISDT 196 Query: 169 QF-----VSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATG------ 217 + GT+ Y+ P++ + + L ++H + Y D++S G+ + A Sbjct: 197 NEVDIPPNTRVGTKRYMPPEVLDES-LNRNHFQSY-IMADMYSFGLILWEVARRCVSGGI 254 Query: 218 ----SLPFRPFEGPRRNKEVMYKII 238 LP+ + E M +I+ Sbjct: 255 VEEYQLPYHDLVPSDPSYEDMREIV 279 >4M66-A nrPDB Length = 325 Score = 147 bits (371), Expect = 2e-35, Method: Composition-based stats. Identities = 60/308 (19%), Positives = 114/308 (37%), Gaps = 51/308 (16%) Query: 13 DILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFA 72 + +G+G VFR H+ A+K+ N+ E + + L ++N++ L Sbjct: 26 EFVGKGGFGVVFRAHHRTWNHDVAVKIVNSKKISW-------EVKAMVNLRNENVLLLLG 78 Query: 73 IEEETTTRHK---VLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE- 128 + E+ L+ F GSL +L+ + P +L++VV GM +L Sbjct: 79 VTEDLQWDFVSGQALVTRFMENGSLAGLLQPEAPR---PWPLLCRLLQEVVLGMCYLHSL 135 Query: 129 -NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAAR-------ELEDDEQFVSLYGTEEYL 180 ++HRD+KP NI+ D + KL DFG + GT YL Sbjct: 136 DPPLLHRDLKPSNILL----DPELHAKLADFGLSTFQGGSQSGSGSGSGSRDSGGTLAYL 191 Query: 181 HPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITG 240 P++ + L+ D++S G+ + G E +K + + Sbjct: 192 DPELLFKVNLKA------SKASDVYSFGILVWAVLAGR------EAELVDKTSLIR---- 235 Query: 241 KPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFA 300 + + P+ ++P + GL+ L ++ E F Sbjct: 236 -----ETVCDRQSRPPL---TELPPGSPETPGLEKLKELMIHCWGS-QSENRPSFQDCEP 286 Query: 301 ETSDILHR 308 +T+++ + Sbjct: 287 KTNEVYNL 294 >5VD3-A nrPDB Length = 311 Score = 146 bits (369), Expect = 3e-35, Method: Composition-based stats. Identities = 57/204 (27%), Positives = 86/204 (42%), Gaps = 20/204 (9%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKV-FNNISFLRPVDVQMREFEVLKKL-NHKNIVKLFA 72 LG G+ VF+ R K+ G L+A+K + + ++ E +K+ H V+L Sbjct: 65 LGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQ 124 Query: 73 IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIV 132 EE L E C SL E + LPE++ LRD + + HL G+V Sbjct: 125 AWEEGGI--LYLQTELC-GPSLQQHCEAWGAS--LPEAQVWGYLRDTLLALAHLHSQGLV 179 Query: 133 HRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRK 192 H D+KP NI + KL DFG EL G Y+ P++ + + Sbjct: 180 HLDVKPANIFLG----PRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGS---- 231 Query: 193 DHQKKYGATVDLWSIGVTFYHAAT 216 YG D++S+G+T A Sbjct: 232 -----YGTAADVFSLGLTILEVAC 250 >3Q4U-A nrPDB Length = 301 Score = 146 bits (368), Expect = 4e-35, Method: Composition-based stats. Identities = 66/310 (21%), Positives = 114/310 (36%), Gaps = 55/310 (17%) Query: 1 MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLK 60 MQ T L + +G+G V+RG + G+ A+K+F++ R RE E+ Sbjct: 2 MQRTVARDITLLECVGKGRYGEVWRGSWQ--GENVAVKIFSS----RDEKSWFRETELYN 55 Query: 61 --KLNHKNIVKLF--AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVL 116 L H+NI+ + ++ LI + GSLY L+ L L ++ Sbjct: 56 TVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQ----LTTLDTVSCLRIV 111 Query: 117 RDVVGGMNHLR--------ENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDE 168 + G+ HL + I HRD+K NI+ + D G A Sbjct: 112 LSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILV----KKNGQCCIADLGLAVMHSQST 167 Query: 169 QFVSL-----YGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATG------ 217 + + GT+ Y+ P++ + ++ D Y VD+W+ G+ + A Sbjct: 168 NQLDVGNNPRVGTKRYMAPEVLD-ETIQVDCFDSY-KRVDIWAFGLVLWEVARRMVSNGI 225 Query: 218 ----SLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGL 273 PF + E M K++ Q+ N P W D +L+ Sbjct: 226 VEDYKPPFYDVVPNDPSFEDMRKVVCVD--------QQRPNIPNRWFSD----PTLTSLA 273 Query: 274 QVLLTPVLAN 283 +++ N Sbjct: 274 KLMKECWYQN 283 >5XVU-A nrPDB Length = 332 Score = 146 bits (368), Expect = 4e-35, Method: Composition-based stats. Identities = 48/240 (20%), Positives = 91/240 (37%), Gaps = 24/240 (10%) Query: 1 MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLK 60 +Q + + + +G+G + VF G + A + RE ++L+ Sbjct: 25 LQWNKPNRYEIMKKIGRGKYSEVFNGYDTECNRPCA----IKVLKPVKKKKIKREIKILQ 80 Query: 61 KLNH-KNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDV 119 LN NI+KL I ++ T+ LI E+ T+ + + + + Sbjct: 81 NLNGGPNIIKLLDIVKDPVTKTPSLIFEYINNIDFKTL------YPKFTDKDIRYYIYQI 134 Query: 120 VGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEY 179 + +++ GI+HRD+KP NIM + +L +G A +++ + Y Sbjct: 135 LKALDYCHSQGIMHRDVKPHNIMI---DHENRQIRLISWGLAEFYHPGQEYNVRVASRYY 191 Query: 180 LHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIIT 239 P++ L Y ++D+WS+G PF N + + KI Sbjct: 192 KGPELLIDLQL-------YDYSLDIWSLGCMLAGMIFKKEPFF---CGHDNYDQLVKIAK 241 >5AR8-A nrPDB Length = 326 Score = 145 bits (365), Expect = 9e-35, Method: Composition-based stats. Identities = 51/239 (21%), Positives = 90/239 (37%), Gaps = 24/239 (10%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKV--FNNISFLRPVDVQMREFEVLKKLNHKNIVKLFA 72 L +GA+ V RH A+K + +RE E+L K I+ + Sbjct: 40 LSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILG 99 Query: 73 IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN--G 130 I E ++ E+ P GSL +L + + +L ++ G+N+L Sbjct: 100 ICNE--PEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPP 157 Query: 131 IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAAR------ELEDDEQFVSLYGTEEYLHPDM 184 ++H D+K NI+ D + K+ DFG ++ + GT Y+ P+ Sbjct: 158 LLHHDLKTQNILL----DNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPEN 213 Query: 185 YERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS 243 YE + + D++S V + + PF P ++MY + G Sbjct: 214 YEP-----GQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNP---LQIMYSVSQGHRP 264 >4MD7-E nrPDB Length = 391 Score = 145 bits (365), Expect = 9e-35, Method: Composition-based stats. Identities = 43/232 (18%), Positives = 88/232 (37%), Gaps = 24/232 (10%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNH-KNI 67 + L LG+G + VF + + V I RE ++L+ L NI Sbjct: 39 YQLVRKLGRGKYSEVFEAINITNNEK----VVVKILKPVKKKKIKREIKILENLRGGPNI 94 Query: 68 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 127 + L I ++ +R L+ E + + L + + + +++ +++ Sbjct: 95 ITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ------TLTDYDIRFYMYEILKALDYCH 148 Query: 128 ENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYER 187 GI+HRD+KP N+M + +L D+G A +++ + + P++ Sbjct: 149 SMGIMHRDVKPHNVMI---DHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVD 205 Query: 188 AVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIIT 239 + Y ++D+WS+G PF N + + +I Sbjct: 206 -------YQMYDYSLDMWSLGCMLASMIFRKEPFF---HGHDNYDQLVRIAK 247 >2PVN-A nrPDB Length = 352 Score = 144 bits (363), Expect = 1e-34, Method: Composition-based stats. Identities = 51/240 (21%), Positives = 96/240 (40%), Gaps = 24/240 (10%) Query: 1 MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLK 60 +Q + + +G+G + VF G + + K I RE ++L+ Sbjct: 46 VQWGEQDDYEVVRKVGRGKYSEVFEGINVNNNE----KCIIKILKPVKKKKIKREIKILQ 101 Query: 61 KL-NHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDV 119 L NIVKL I + ++ LI E+ + VL L + + + ++ Sbjct: 102 NLCGGPNIVKLLDIVRDQHSKTPSLIFEYVNNTD-FKVL-----YPTLTDYDIRYYIYEL 155 Query: 120 VGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEY 179 + +++ GI+HRD+KP N+M + +L D+G A +++ + + Sbjct: 156 LKALDYCHSQGIMHRDVKPHNVMI---DHELRKLRLIDWGLAEFYHPGKEYNVRVASRYF 212 Query: 180 LHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIIT 239 P++ + Y ++D+WS+G F PF F G N + + KI Sbjct: 213 KGPELLVDL-------QDYDYSLDMWSLGCMFAGMIFRKEPF--FYGH-DNHDQLVKIAK 262 >6HMD-A nrPDB Length = 365 Score = 142 bits (359), Expect = 5e-34, Method: Composition-based stats. Identities = 46/251 (18%), Positives = 98/251 (39%), Gaps = 24/251 (9%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNH-KNI 67 + L LG+G + VF + + V I RE ++L+ L NI Sbjct: 55 YQLVRKLGRGKYSEVFEAINITNNER----VVVKILKPVKKKKIKREVKILENLRGGTNI 110 Query: 68 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 127 +KL ++ ++ L+ E+ + + L + + + +++ +++ Sbjct: 111 IKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ------ILTDFDIRFYMYELLKALDYCH 164 Query: 128 ENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYER 187 GI+HRD+KP N+M + Q +L D+G A +++ + + P++ Sbjct: 165 SKGIMHRDVKPHNVMI---DHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVD 221 Query: 188 AVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAIS 247 + Y ++D+WS+G PF + N + + +I + + Sbjct: 222 -------YQMYDYSLDMWSLGCMLASMIFRREPFF---HGQDNYDQLVRIAKVLGTEELY 271 Query: 248 GVQKAENGPID 258 G K + +D Sbjct: 272 GYLKKYHIDLD 282 >6EII-A nrPDB Length = 352 Score = 142 bits (358), Expect = 6e-34, Method: Composition-based stats. Identities = 43/232 (18%), Positives = 88/232 (37%), Gaps = 24/232 (10%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNH-KNI 67 + L LG+G + VF + + V I RE ++L+ L NI Sbjct: 62 YQLVRKLGRGKYSEVFEAINITNNEK----VVVKILKPVKKKKIKREIKILENLRGGPNI 117 Query: 68 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 127 + L I ++ +R L+ E + + L + + + +++ +++ Sbjct: 118 ITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ------TLTDYDIRFYMYEILKALDYCH 171 Query: 128 ENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYER 187 GI+HRD+KP N+M + +L D+G A +++ + + P++ Sbjct: 172 SMGIMHRDVKPHNVMI---DHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVD 228 Query: 188 AVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIIT 239 + Y ++D+WS+G PF N + + +I Sbjct: 229 -------YQMYDYSLDMWSLGCMLASMIFRKEPFF---HGHDNYDQLVRIAK 270 >6BFN-A nrPDB Length = 342 Score = 139 bits (351), Expect = 4e-33, Method: Composition-based stats. Identities = 50/221 (22%), Positives = 77/221 (34%), Gaps = 32/221 (14%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRP---VDVQMREFEVLKKLNHKNIVKLF 71 +G+G V+R + T ++A+K + L + E E L + H NIV Sbjct: 30 IGEGGFGCVYRAVMRNT--VYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFA 87 Query: 72 AIEEETTTRHKVLIMEFCPCGSLYTVLE-EPSNAYGLPESEFLIVLRDVVGGMNHLR--E 128 + L+ F P GSL L + L + L +L + L Sbjct: 88 GYCAQNGFY--CLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDS 145 Query: 129 NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDE----------QFVSLYGTEE 178 ++H DIK N++ D + KL DFG AR + ++ GT Sbjct: 146 PSLIHGDIKSSNVLL----DERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLA 201 Query: 179 YLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSL 219 YL + + L D D +S GV G Sbjct: 202 YLPEEYIKTGRLAVD--------TDTFSFGVVVLETLAGQR 234 >3G2F-A nrPDB Length = 336 Score = 138 bits (348), Expect = 9e-33, Method: Composition-based stats. Identities = 57/293 (19%), Positives = 109/293 (37%), Gaps = 43/293 (14%) Query: 11 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLK--KLNHKNIV 68 L +++G+G V++G A+KVF+ + E + + + H NI Sbjct: 17 LLELIGRGRYGAVYKG--SLDERPVAVKVFS----FANRQNFINEKNIYRVPLMEHDNIA 70 Query: 69 KLFAIEEETTTR---HKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 125 + +E T +L+ME+ P GSL L + + + V G+ + Sbjct: 71 RFIVGDERVTADGRMEYLLVMEYYPNGSLCKYL----SLHTSDWVSSCRLAHSVTRGLAY 126 Query: 126 LR---------ENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAAREL---------EDD 167 L + I HRD+ N++ ++DFG + L E+D Sbjct: 127 LHTELPRGDHYKPAISHRDLNSRNVLV----KNDGTCVISDFGLSMRLTGNRLVRPGEED 182 Query: 168 EQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGP 227 +S GT Y+ P++ E AV +D + VD++++G+ ++ P E Sbjct: 183 NAAISEVGTIRYMAPEVLEGAVNLRDCESAL-KQVDMYALGLIYWEIFMRCTDLFPGESV 241 Query: 228 RRNKEVMYKIITGKPS-----GAISGVQKAENGPIDWSGDMPVSCSLSRGLQV 275 + + P+ +S ++ P W + SL ++ Sbjct: 242 PEYQMAFQTEVGNHPTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETIED 294 >3SV0-A nrPDB Length = 483 Score = 138 bits (347), Expect = 9e-33, Method: Composition-based stats. Identities = 61/303 (20%), Positives = 114/303 (37%), Gaps = 50/303 (16%) Query: 1 MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLK 60 M+ + + L +G G+ ++ G + +T + AIK N+ P + E ++ + Sbjct: 1 MEPRVGNKFRLGRKIGSGSFGEIYLGTNIQTNEEVAIK-LENVKTKHP--QLLYESKIYR 57 Query: 61 KLNH----KNIVKLFAIEEETTTRHKVLIMEFC--PCGSLYTVLEEPSNAYGLPESEFLI 114 L N V+ F +E + + VL+M+ L+ + L L+ Sbjct: 58 ILQGGTGIPN-VRWFGVEGD----YNVLVMDLLGPSLEDLFNF-----CSRKLSLKTVLM 107 Query: 115 VLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQF---- 170 + ++ + + +HRDIKP N + +G VY + DFG A++ D Sbjct: 108 LADQMINRVEFVHSKSFLHRDIKPDNFLMGLGRRANQVY-IIDFGLAKKYRDTSTHQHIP 166 Query: 171 ----VSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEG 226 +L GT Y + + DL S+G + GSLP++ + Sbjct: 167 YRENKNLTGTARYAS--------VNTHLGIEQSRRDDLESLGYVLMYFLRGSLPWQGLKA 218 Query: 227 PRRNKEVMYKIITGKPSGAISGVQKAENGPIDWSG-----------DMPVSCSLSRGLQV 275 + K+ KI K + +I + + P +++ D P L R + Sbjct: 219 GTK-KQKYEKISEKKVATSIEALCRGY--PTEFASYFHYCRSLRFDDKPDYSYLKRLFRD 275 Query: 276 LLT 278 L Sbjct: 276 LFI 278 >2X7G-A nrPDB Length = 389 Score = 136 bits (342), Expect = 4e-32, Method: Composition-based stats. Identities = 55/290 (18%), Positives = 99/290 (34%), Gaps = 70/290 (24%) Query: 6 NHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNH- 64 N + + LG G + V+ + A+KV + + + E ++LK + Sbjct: 30 NGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHY--TETALDEIKLLKCVRES 87 Query: 65 ----KN---IVKLFAIEEET--TTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIV 115 N +V+L + + H ++ E L +++ SN GLP + Sbjct: 88 DPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIK--SNYQGLPVRCVKSI 145 Query: 116 LRDVVGGMNHLREN-GIVHRDIKPGNIMRVIGE--------------------------- 147 +R V+ G+++L I+H DIKP NI+ + + Sbjct: 146 IRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAVS 205 Query: 148 ----------------DGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLR 191 + K+ D G A + + F T +Y ++ A Sbjct: 206 TAPAADLLVNPLDPRNADKIRVKIADLGNACWVH--KHFTEDIQTRQYRSIEVLIGA--- 260 Query: 192 KDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPR--RNKEVMYKIIT 239 Y D+WS + ATG F P G R+++ + II Sbjct: 261 -----GYSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIE 305 >4MWI-A nrPDB Length = 294 Score = 135 bits (341), Expect = 5e-32, Method: Composition-based stats. Identities = 60/294 (20%), Positives = 108/294 (36%), Gaps = 39/294 (13%) Query: 2 QSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLR---PVDVQMREFEV 58 + S W+L + + +++G + + AIKVF + +E + Sbjct: 22 EQLSGSPWILLR---ENEVSTLYKGEYHRA--PVAIKVFKKLQAGSIAIVRQTFNKEIKT 76 Query: 59 LKKLNHKNIVKLFAIE--EETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVL 116 +KK NI+++F I E T ++ME+C G+L +L+ + L + ++++ Sbjct: 77 MKKFESPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLDREKD---LTLGKRMVLV 133 Query: 117 RDVVGGMNHLR--ENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGA-----ARELEDDEQ 169 G+ L E +H I+ N + G KL F + L + Sbjct: 134 LGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQ----VKLAGFELRKTQTSMSLGTTRE 189 Query: 170 FVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRR 229 + YL P E D +Y +++S G+ + ATG +PF+ Sbjct: 190 KTDRVKSTAYLSPQELE------DVFYQYDVKSEIYSFGIVLWEIATGDIPFQGC----- 238 Query: 230 NKEVMYKIITGKPSGAISGVQKAENGPIDWSG----DMPVSCSLSRGLQVLLTP 279 N E + K++ K G D V S+ L+ L T Sbjct: 239 NSEKIRKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKKLSTF 292 >2H34-A nrPDB Length = 309 Score = 135 bits (341), Expect = 5e-32, Method: Composition-based stats. Identities = 47/247 (19%), Positives = 89/247 (36%), Gaps = 23/247 (9%) Query: 8 LWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPV--DVQMREFEVLKKLNHK 65 + L ++G+G +V+ + A+K+ + PV RE +L Sbjct: 35 PYRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRTRMQREARTAGRLQEP 94 Query: 66 NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 125 ++V + E + M L +L L + ++R + ++ Sbjct: 95 HVVPIHDFGEI--DGQLYVDMRLINGVDLAAMLRRQG---PLAPPRAVAIVRQIGSALDA 149 Query: 126 LRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDE--QFVSLYGTEEYLHPD 183 G HRD+KP NI+ + L DFG A D++ Q + GT Y+ P+ Sbjct: 150 AHAAGATHRDVKPENILVSADD----FAYLVDFGIASATTDEKLTQLGNTVGTLYYMAPE 205 Query: 184 MYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS 243 + + D++++ Y TGS P++ + + I +PS Sbjct: 206 RFSESHA--------TYRADIYALTCVLYECLTGSPPYQGDQLSVMGAHINQAI--PRPS 255 Query: 244 GAISGVQ 250 G+ Sbjct: 256 TVRPGIP 262 >3REP-A nrPDB Length = 271 Score = 135 bits (340), Expect = 6e-32, Method: Composition-based stats. Identities = 49/263 (18%), Positives = 97/263 (36%), Gaps = 21/263 (7%) Query: 21 ANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIEEETTTR 80 +++GR + + + + S + D E L+ +H N++ + + Sbjct: 24 GELWKGRWQGNDIVVKVLKVRDWSTRKSRD-FNEECPRLRIFSHPNVLPVLGACQSPPAP 82 Query: 81 HKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR--ENGIVHRDIKP 138 H LI + P GSLY VL E +N + + +S+ + D+ GM L E I + Sbjct: 83 HPTLITHWMPYGSLYNVLHEGTN-FVVDQSQAVKFALDMARGMAFLHTLEPLIPRHALNS 141 Query: 139 GNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKY 198 ++M I ED + + D + + + + ++ P+ L+K + Sbjct: 142 RSVM--IDEDMTARISMADVKFS--FQSPGRMYA----PAWVAPE-----ALQKKPEDTN 188 Query: 199 GATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK-PSGAISGVQKAENGPI 257 + D+WS V + T +PF +V + + P G V K + Sbjct: 189 RRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTIPPGISPHVSKLMKICM 248 Query: 258 DWSGDMPVSCSLSRGLQVLLTPV 280 + P + +L + Sbjct: 249 NED---PAKRPKFDMIVPILEKM 268 >5J0A-A nrPDB Length = 300 Score = 134 bits (338), Expect = 1e-31, Method: Composition-based stats. Identities = 58/267 (21%), Positives = 105/267 (39%), Gaps = 36/267 (13%) Query: 11 LSDILGQGATANVFRGRHKKTG---DLFAIKVFNNISFLRPVDV----QMREFEVLKKLN 63 LG G NV+ + G +A+K N I V M E ++LK L+ Sbjct: 13 FMQKLGFGTGVNVYLMKRSPRGLSHSPWAVKKINPICNDHYRSVYQKRLMDEAKILKSLH 72 Query: 64 HKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEE--PSNAYGLPESEFLIVLRDVVG 121 H NIV + E L ME+ SL ++EE ++ P + L V ++ Sbjct: 73 HPNIVG-YRAFTEANDGSLCLAMEYGGEKSLNDLIEERYKASQDPFPAAIILKVALNMAR 131 Query: 122 GMNHLR-ENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVS----LYGT 176 G+ +L E ++H DIK N++ + K+ D G + L+++ + GT Sbjct: 132 GLKYLHQEKKLLHGDIKSSNVVIKGDFE---TIKICDVGVSLPLDENMEVTDPEACYIGT 188 Query: 177 EEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF-----------RPFE 225 E + + E + D D+++ G+T + T S+P + F+ Sbjct: 189 EPWKPKEAVEENGVITD-------KADIFAFGLTLWEMMTLSIPHINLSNDDDDEDKTFD 241 Query: 226 GPRRNKEVMYKIITGKPSGAISGVQKA 252 + E Y + +P + + ++ Sbjct: 242 ESDFDDEAYYAALGTRPPINMEELDES 268 >4WUA-A nrPDB Length = 401 Score = 133 bits (336), Expect = 2e-31, Method: Composition-based stats. Identities = 68/361 (18%), Positives = 122/361 (33%), Gaps = 77/361 (21%) Query: 6 NHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNH- 64 N + + LG G + V+ + A+KV + + + E +LK + + Sbjct: 40 NGRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHY--TETALDEIRLLKSVRNS 97 Query: 65 -KN------IVKLFAIEEET--TTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIV 115 N +V+L + + H ++ E L +++ SN GLP + Sbjct: 98 DPNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIK--SNYQGLPLPCVKKI 155 Query: 116 LRDVVGGMNHLREN-GIVHRDIKPGNIMRVIGED-------------------------- 148 ++ V+ G+++L I+H DIKP NI+ + E Sbjct: 156 IQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVS 215 Query: 149 -------------------GQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAV 189 + K+ D G A + + F T +Y ++ + Sbjct: 216 TAPATAGNFLVNPLEPKNAEKLKVKIADLGNACWVH--KHFTEDIQTRQYRSLEVLIGS- 272 Query: 190 LRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPR--RNKEVMYKIIT--GKPSGA 245 Y D+WS + ATG F P G R+++ + II GK Sbjct: 273 -------GYNTPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRK 325 Query: 246 ISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFAETSDI 305 + K GD+ +++ L VL E QE+ GF F ++ Sbjct: 326 LIVAGKYSKEFFTKKGDL---KHITKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLEL 382 Query: 306 L 306 + Sbjct: 383 I 383 >4M69-B nrPDB Length = 283 Score = 133 bits (335), Expect = 2e-31, Method: Composition-based stats. Identities = 53/273 (19%), Positives = 109/273 (39%), Gaps = 31/273 (11%) Query: 20 TANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMR---EFEVLKKLNHKNIVKLFAIEEE 76 + ++RG + ++ IKVFNN V+ E + +KK + NI+++F I + Sbjct: 22 MSTIYRGEYHRS--PVTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICID 79 Query: 77 TTTRHK--VLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHR 134 T + ++ME+C G+L +L+ + L S +++ G+ L + +HR Sbjct: 80 QTVKPPEFSIVMEYCELGTLRELLDREKD---LTMSVRSLLVLRAARGLYRLHHSETLHR 136 Query: 135 DIKPGNIMRVIGEDGQSVYKLTDFGAARELED-----DEQFVSLYGTEEYLHPDMYERAV 189 +I + + G KL F ++ + Y+ P+ Sbjct: 137 NISSSSFLVA----GGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERL---- 188 Query: 190 LRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSG--AIS 247 K+ Y +++S G+ + ATG +PF + ++ +E++ + +P G Sbjct: 189 --KNPFCLYDIKAEIYSFGIVLWEIATGKIPFEGCDS-KKIRELVAEDKKQEPVGQDCPE 245 Query: 248 GVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPV 280 +++ N P G+ L+ V Sbjct: 246 LLREIINEC---RAHEPSQRPSVDGILERLSAV 275 >3SOC-A nrPDB Length = 322 Score = 133 bits (335), Expect = 2e-31, Method: Composition-based stats. Identities = 54/256 (21%), Positives = 100/256 (39%), Gaps = 45/256 (17%) Query: 11 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEV--LKKLNHKNIV 68 L ++ +G V++ + + A+K+F ++ E+EV L + H+NI+ Sbjct: 28 LLEVKARGRFGCVWKAQLLN--EYVAVKIFP----IQDKQSWQNEYEVYSLPGMKHENIL 81 Query: 69 KLFAIEEETT--TRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 126 + E+ T LI F GSL L+ A + +E + + G+ +L Sbjct: 82 QFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLK----ANVVSWNELCHIAETMARGLAYL 137 Query: 127 RE----------NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDE---QFVSL 173 E I HRDIK N++ + DFG A + E + Sbjct: 138 HEDIPGLKDGHKPAISHRDIKSKNVLL----KNNLTACIADFGLALKFEAGKSAGDTHGQ 193 Query: 174 YGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGS-----------LPFR 222 GT Y+ P++ E A+ + +D++++G+ + A+ LPF Sbjct: 194 VGTRRYMAPEVLEGAINFQRDAF---LRIDMYAMGLVLWELASRCTAADGPVDEYMLPFE 250 Query: 223 PFEGPRRNKEVMYKII 238 G + E M +++ Sbjct: 251 EEIGQHPSLEDMQEVV 266 >4LFI-A nrPDB Length = 374 Score = 132 bits (333), Expect = 4e-31, Method: Composition-based stats. Identities = 52/298 (17%), Positives = 103/298 (34%), Gaps = 60/298 (20%) Query: 3 STSNHLWLLSDILGQGATANVFRGRHKKTGDLFAI------------------------K 38 ST+ + + + +G+G + VF+G + I K Sbjct: 36 STNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEK 95 Query: 39 VFNNISFLRPVDVQMREFE-VLKKLN----------HKNIVKLFAIEEETTTRHKVLIME 87 V + + E VLK + H NI+ LF I ++ ++ L+ E Sbjct: 96 VPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFE 155 Query: 88 FCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGE 147 + + L + E + +++ +++ GI+HRD+KP N+M + Sbjct: 156 YVDNVDFRIL------YPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMI---D 206 Query: 148 DGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSI 207 +L D+G A + ++ + + P++ + Y ++DLWS Sbjct: 207 HKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVD-------YRMYDYSLDLWSF 259 Query: 208 GVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGPIDWSGDMPV 265 G PF N + + KI+ + G E + + +P Sbjct: 260 GTMLASMIFKREPFF---HGTSNTDQLVKIVK------VLGTSDFEKYLLKYEITLPR 308 >4BTK-A nrPDB Length = 337 Score = 132 bits (333), Expect = 5e-31, Method: Composition-based stats. Identities = 49/238 (20%), Positives = 82/238 (34%), Gaps = 23/238 (9%) Query: 7 HLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHK- 65 W + +G G ++ T + A+KV S +P V E VLKKL K Sbjct: 56 DRWKVLKKIGGGGFGEIYEAMDLLTRENVALKV---ESAQQPKQVLKMEVAVLKKLQGKD 112 Query: 66 NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 125 ++ + + ++M+ +L L S L + + ++ + Sbjct: 113 HVCRFIGCGRN--EKFNYVVMQL-QGRNLAD-LRRSQPRGTFTLSTTLRLGKQILESIEA 168 Query: 126 LRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARE-------LEDDEQFVSLYGTEE 178 + G +HRDIKP N + DFG AR+ + GT Sbjct: 169 IHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVR 228 Query: 179 YLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYK 236 Y + ++ G DLWS+ A G LP+R + + + K Sbjct: 229 YAS--------VNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKEK 278 >4BTF-A nrPDB Length = 469 Score = 132 bits (332), Expect = 6e-31, Method: Composition-based stats. Identities = 45/219 (20%), Positives = 90/219 (41%), Gaps = 25/219 (11%) Query: 20 TANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMR---EFEVLKKLNHKNIVKLFAIEEE 76 + ++RG + ++ IKVFNN V+ E + +KK + NI+++F I + Sbjct: 208 MSTIYRGEYHRS--PVTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICID 265 Query: 77 TTTRHK--VLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHR 134 T + ++ME+C G+L +L+ + L S +++ G+ L + +HR Sbjct: 266 QTVKPPEFSIVMEYCELGTLRELLDREKD---LTMSVRSLLVLRAARGLYRLHHSETLHR 322 Query: 135 DIKPGNIMRVIGEDGQSVYKLTDFGAARELED-----DEQFVSLYGTEEYLHPDMYERAV 189 +I + + G KL F ++ + Y+ P+ Sbjct: 323 NISSSSFLVA----GGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERL---- 374 Query: 190 LRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPR 228 K+ Y +++S G+ + ATG +PF + + Sbjct: 375 --KNPFCLYDIKAEIYSFGIVLWEIATGKIPFEGCDSKK 411 >4NFN-A nrPDB Length = 309 Score = 132 bits (332), Expect = 6e-31, Method: Composition-based stats. Identities = 49/238 (20%), Positives = 82/238 (34%), Gaps = 23/238 (9%) Query: 7 HLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHK- 65 W + +G G ++ T + A+KV S +P V E VLKKL K Sbjct: 21 DRWKVLKKIGGGGFGEIYEAMDLLTRENVALKV---ESAQQPKQVLKMEVAVLKKLQGKD 77 Query: 66 NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 125 ++ + + ++M+ +L L S L + + ++ + Sbjct: 78 HVCRFIGCGRN--EKFNYVVMQL-QGRNLAD-LRRSQPRGTFTLSTTLRLGKQILESIEA 133 Query: 126 LRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARE-------LEDDEQFVSLYGTEE 178 + G +HRDIKP N + DFG AR+ + GT Sbjct: 134 IHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVR 193 Query: 179 YLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYK 236 Y + ++ G DLWS+ A G LP+R + + + K Sbjct: 194 YAS--------VNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKEK 243 >5E8V-A nrPDB Length = 316 Score = 131 bits (330), Expect = 9e-31, Method: Composition-based stats. Identities = 52/253 (20%), Positives = 93/253 (36%), Gaps = 46/253 (18%) Query: 1 MQSTSNHLWLLSDILGQGATANVFRGRHKKTG----DLFAIKVFNNISFLRPVDVQMREF 56 M +T L ++G+G A V++ + K+ + A+K+F + E Sbjct: 3 MHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYAS----WKTEK 58 Query: 57 EVLK--KLNHKNIVKLFAIEEETTT--RHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEF 112 ++ L H+NI++ EE T + LI F G+L L + + Sbjct: 59 DIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRH----VISWEDL 114 Query: 113 LIVLRDVVGGMNHLRE---------NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARE 163 + + G+ HL IVHRD+K NI+ L DFG + Sbjct: 115 RKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILV----KNDLTCCLCDFGLSLR 170 Query: 164 LE-----DDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATG- 217 L+ DD GT Y+ P++ A+ ++ + D++S+ + + + Sbjct: 171 LDPTLSVDDLANSGQVGTARYMAPEVLASAMNLENVESF--KQTDVYSMALVLWEMTSRC 228 Query: 218 ---------SLPF 221 PF Sbjct: 229 NAVGEVKDYEPPF 241 >4TN6-A nrPDB Length = 318 Score = 128 bits (322), Expect = 9e-30, Method: Composition-based stats. Identities = 58/311 (18%), Positives = 114/311 (36%), Gaps = 35/311 (11%) Query: 1 MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLK 60 M+ + + L +G G+ +++ G G+ AIK + P E ++ K Sbjct: 1 MELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIK-LECVKTKHPQLHI--ESKIYK 57 Query: 61 KLNH----KNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVL 116 + I + V++ME SL + S + L L++ Sbjct: 58 MMQGGVGIPTI-----RWCGAEGDYNVMVMELL-GPSLEDLFNFCSRKFSL--KTVLLLA 109 Query: 117 RDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQF------ 170 ++ + ++ +HRD+KP N + +G+ G VY + DFG A++ D Sbjct: 110 DQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVY-IIDFGLAKKYRDARTHQHIPYR 168 Query: 171 --VSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPR 228 +L GT Y + + DL S+G + GSLP++ + Sbjct: 169 ENKNLTGTARYAS--------INTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAAT 220 Query: 229 RNKEVMYKIITGKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEAD 288 + ++ +I K S I + K P +++ + SL + + + Sbjct: 221 K-RQKYERISEKKMSTPIEVLCKGY--PSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLF 277 Query: 289 QEKCWGFDQFF 299 + + +D F Sbjct: 278 HRQGFSYDYVF 288 >5VDK-A nrPDB Length = 297 Score = 128 bits (321), Expect = 9e-30, Method: Composition-based stats. Identities = 52/274 (18%), Positives = 102/274 (37%), Gaps = 41/274 (14%) Query: 1 MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKV-FNNISFLRPVDVQMREFEVL 59 M S +L + +G G V++ + G ++AIK + L + + E Sbjct: 9 MASRYEKEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSALHEVYAH 68 Query: 60 KKL-NHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYG-LPESEFLIVLR 117 L +H ++V+ ++ E H ++ E+C GSL + E + + E + +L Sbjct: 69 AVLGHHPHVVRYYSSWAE--DDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILL 126 Query: 118 DVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQS-------------------VYKLTDF 158 + G+N++ + +VH DIKP NI +S +YK+ D Sbjct: 127 QISLGLNYIHNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGDL 186 Query: 159 GAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGS 218 G A + G +L ++ + ++ D++++G+T AA Sbjct: 187 GHATSINKP---KVEEGDSRFLANEILQE-------DYRHLPKADIFALGLTIAVAA--- 233 Query: 219 LPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKA 252 E N + I G + ++ Sbjct: 234 ----GAESLPTNGAAWHHIRKGNFPDVPQELSES 263 >2WTK-B nrPDB Length = 373 Score = 126 bits (316), Expect = 4e-29, Method: Composition-based stats. Identities = 55/279 (19%), Positives = 109/279 (39%), Gaps = 28/279 (10%) Query: 9 WLLSDILGQGATA---NVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMR-EFEVLKKLNH 64 + L ++G+G V R+K TG+ ++ N + + ++ E V K NH Sbjct: 11 YELLTVIGKG-FEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNH 69 Query: 65 KNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 124 NIV A ++ F GS ++ G+ E +L+ V+ ++ Sbjct: 70 PNIVPYRATFIADN--ELWVVTSFMAYGSAKDLICTH-FMDGMNELAIAYILQGVLKALD 126 Query: 125 HLRENGIVHRDIKPGNIMRVIGEDG-----QSVYKLTDFGAARELEDDEQFVSLYGTEEY 179 ++ G VHR +K +I+ + +S + G + + D S+ + Sbjct: 127 YIHHMGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSVKVLP-W 185 Query: 180 LHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIIT 239 L P++ ++ + + Y A D++S+G+T A G +PF+ +++ Sbjct: 186 LSPEVLQQNL------QGYDAKSDIYSVGITACELANGHVPFKDMPA--------TQMLL 231 Query: 240 GKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLT 278 K +G + + P + P + GL LT Sbjct: 232 EKLNGTVPCLLDTSTIPAEELTMSPSRSVANSGLSDSLT 270 >3QD2-B nrPDB Length = 332 Score = 125 bits (313), Expect = 9e-29, Method: Composition-based stats. Identities = 45/271 (16%), Positives = 85/271 (31%), Gaps = 84/271 (30%) Query: 16 GQGATANVFRGRHKKTGDLFAI-------------KVFNNISFLRPVDV----------- 51 G+G VF ++K +AI KV + L ++ Sbjct: 15 GRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWL 74 Query: 52 ---------QMREFEV------------------------LKKLNHKNIVKLFAIEEETT 78 +M E + + + KN V ++ + Sbjct: 75 ETPPEKWQEEMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFSTKNTVG--QLQPSSP 132 Query: 79 TRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKP 138 + + M+ C +L + + L + + + L G++HRD+KP Sbjct: 133 KVYLYIQMQLCRKENLKDWMNRRCSLEDREHGVCLHIFIQIAEAVEFLHSKGLMHRDLKP 192 Query: 139 GNIMRVIGEDGQSVYKLTDFGAARELEDDEQ-------------FVSLYGTEEYLHPDMY 185 NI + + V K+ DFG ++ DE+ GT+ Y+ P+ Sbjct: 193 SNIFFTMDD----VVKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQVGTKLYMSPEQI 248 Query: 186 ERAVLRKDHQKKYGATVDLWSIGVTFYHAAT 216 H Y VD++S+G+ + Sbjct: 249 --------HGNNYSHKVDIFSLGLILFELLY 271 >5VC6-A nrPDB Length = 289 Score = 124 bits (311), Expect = 2e-28, Method: Composition-based stats. Identities = 57/289 (19%), Positives = 104/289 (35%), Gaps = 42/289 (14%) Query: 13 DILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDV-QMREFEVLKKL-NHKNIVKL 70 + +G G +VF+ + G ++AIK + +RE L H ++V+ Sbjct: 17 EKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSHVVRY 76 Query: 71 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYG-LPESEFLIVLRDVVGGMNHLREN 129 F+ E H ++ E+C GSL + E E+E +L V G+ ++ Sbjct: 77 FSAWAE--DDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIHSM 134 Query: 130 GIVHRDIKPGNIMRVIGE---------------DGQSVYKLTDFGAARELEDDEQFVSLY 174 +VH DIKP NI + ++K+ D G + + Sbjct: 135 SLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQ---VEE 191 Query: 175 GTEEYLHPDMYERAVLRKDHQKKYG--ATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKE 232 G +L ++ Q+ Y D++++ +T A G+ P RN + Sbjct: 192 GDSRFLANEVL---------QENYTHLPKADIFALALTV-VCAAGAEPLP------RNGD 235 Query: 233 VMYKIITGKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVL 281 ++I G+ I V E + P + ++ VL Sbjct: 236 QWHEIRQGRLP-RIPQVLSQEFTELLKVMIHPDPERRPSAMALVKHSVL 283 >2QLU-A nrPDB Length = 314 Score = 122 bits (307), Expect = 5e-28, Method: Composition-based stats. Identities = 51/257 (19%), Positives = 95/257 (36%), Gaps = 46/257 (17%) Query: 11 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKK--LNHKNIV 68 L +I +G V++ + A+K+F L+ E E+ + H+N++ Sbjct: 19 LLEIKARGRFGCVWKAQLMND--FVAVKIFP----LQDKQSWQSEREIFSTPGMKHENLL 72 Query: 69 KLFAIEEETTTRH--KVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 126 + A E+ + LI F GSL L+ + +E V + G+++L Sbjct: 73 QFIAAEKRGSNLEVELWLITAFHDKGSLTDYLK----GNIITWNELCHVAETMSRGLSYL 128 Query: 127 RE-----------NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQ---FVS 172 E I HRD K N++ L DFG A E + Sbjct: 129 HEDVPWCRGEGHKPSIAHRDFKSKNVLL----KSDLTAVLADFGLAVRFEPGKPPGDTHG 184 Query: 173 LYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGS-----------LPF 221 GT Y+ P++ E A+ + +D++++G+ + + LPF Sbjct: 185 QVGTRRYMAPEVLEGAINFQRDAF---LRIDMYAMGLVLWELVSRCKAADGPVDEYMLPF 241 Query: 222 RPFEGPRRNKEVMYKII 238 G + E + +++ Sbjct: 242 EEEIGQHPSLEELQEVV 258 >3VHK-A nrPDB Length = 368 Score = 122 bits (306), Expect = 6e-28, Method: Composition-based stats. Identities = 47/215 (21%), Positives = 82/215 (38%), Gaps = 30/215 (13%) Query: 88 FCPCGSLYTVLEEPSN----AYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMR 143 F SL V EE + L + V GM L +HRD+ NI+ Sbjct: 174 FVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILL 233 Query: 144 VIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTE---EYLHPDMYERAVLRKDHQKKYGA 200 ++V K+ DFG AR++ D +V +++ P+ + Y Sbjct: 234 S----EKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIF--------DRVYTI 281 Query: 201 TVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVMYKIITGKPSGAI-SGVQKAENGPID 258 D+WS GV + + G+ P+ G + ++E ++ G A + +D Sbjct: 282 QSDVWSFGVLLWEIFSLGASPYP---GVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLD 338 Query: 259 -WSGDMPVSCSLSRGLQVLLTPVLANILEADQEKC 292 W G+ + S L L N+L+A+ ++ Sbjct: 339 CWHGEPSQRPTFSE-----LVEHLGNLLQANAQQD 368 Score = 82.3 bits (202), Expect = 6e-16, Method: Composition-based stats. Identities = 25/108 (23%), Positives = 38/108 (35%), Gaps = 7/108 (6%) Query: 4 TSNHLWLLSDILGQGATANVFRGR-----HKKTGDLFAIKVFNNISFLRPVDVQMREFEV 58 L LG+GA V T A+K+ + M E ++ Sbjct: 26 FPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKI 85 Query: 59 LKKLNHK-NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAY 105 L + H N+V L + V++ EFC G+L T L N + Sbjct: 86 LIHIGHHLNVVNLLGACTKPGGPLMVIV-EFCKFGNLSTYLRSKRNEF 132 >2PMN-X nrPDB Length = 348 Score = 122 bits (306), Expect = 6e-28, Method: Composition-based stats. Identities = 46/236 (19%), Positives = 90/236 (38%), Gaps = 39/236 (16%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVD----------------VQ 52 + + L QG + K +A+K + + D Sbjct: 33 YRIIRTLNQGKFNKIILCE--KDNKFYALKKYEKSLLEKKRDFTKSNNDKISIKSKYDDF 90 Query: 53 MREFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSL------YTVLEEPSNAYG 106 E +++ + ++ + I +I E+ S+ + VL++ + Sbjct: 91 KNELQIITDIKNEYCLTCEGIITNYD--EVYIIYEYMENDSILKFDEYFFVLDKNYTCF- 147 Query: 107 LPESEFLIVLRDVVGGMNHLR-ENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELE 165 +P +++ V+ +++ E I HRD+KP NI+ D KL+DFG + + Sbjct: 148 IPIQVIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILM----DKNGRVKLSDFGESEYMV 203 Query: 166 DDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 D++ GT E++ P+ + GA VD+WS+G+ Y +PF Sbjct: 204 -DKKIKGSRGTYEFMPPEFFSNE------SSYNGAKVDIWSLGICLYVMFYNVVPF 252 >2CMW-A nrPDB Length = 310 Score = 122 bits (306), Expect = 6e-28, Method: Composition-based stats. Identities = 59/297 (19%), Positives = 115/297 (38%), Gaps = 30/297 (10%) Query: 11 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNH--KNIV 68 + +G G + G++ T + AIK I P E+ K+L + + Sbjct: 4 VGKKIGCGNFGELRLGKNLYTNEYVAIK-LEPIKSRAPQLHL--EYRFYKQLGSAGEGLP 60 Query: 69 KLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE 128 +++ ++ +++E SL + + + L L++ ++ M ++ Sbjct: 61 QVYYFGPCG--KYNAMVLELL-GPSLEDLFDLCDRTFTL--KTVLMIAIQLLSRMEYVHS 115 Query: 129 NGIVHRDIKPGNIMR-VIGEDGQSVYKLTDFGAARELEDDE--------QFVSLYGTEEY 179 +++RD+KP N + G + V + DFG A+E D E + SL GT Y Sbjct: 116 KNLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARY 175 Query: 180 LHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIIT 239 + + K+ DL ++G F + GSLP++ + KE KI Sbjct: 176 MS--------INTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKA-DTLKERYQKIGD 226 Query: 240 GKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFD 296 K + I + EN P + + + L + + + ++K + FD Sbjct: 227 TKRNTPIEAL--CENFPEEMATYLRYVRRLDFFEKPDYEYLRTLFTDLFEKKGYTFD 281 >2CHL-A nrPDB Length = 351 Score = 119 bits (299), Expect = 3e-27, Method: Composition-based stats. Identities = 51/248 (20%), Positives = 96/248 (38%), Gaps = 27/248 (10%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNH-KNI 67 + + +G G + G++ T + AIK+ E+ K+L I Sbjct: 32 FRVGKKIGCGNFGELRLGKNLYTNEYVAIKL---EPMKSRAPQLHLEYRFYKQLGSGDGI 88 Query: 68 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 127 +++ ++ +++E SL + + + L L++ ++ M ++ Sbjct: 89 PQVYYFGPCG--KYNAMVLELL-GPSLEDLFDLCDRTFSL--KTVLMIAIQLISRMEYVH 143 Query: 128 ENGIVHRDIKPGNIMR-VIGEDGQSVYKLTDFGAARELEDDE--------QFVSLYGTEE 178 +++RD+KP N + G Q V + DF A+E D E + SL GT Sbjct: 144 SKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTAR 203 Query: 179 YLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKII 238 Y+ + K+ DL ++G F + GSLP++ + KE KI Sbjct: 204 YMS--------INTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKA-DTLKERYQKIG 254 Query: 239 TGKPSGAI 246 K + I Sbjct: 255 DTKRATPI 262 >4F9B-A nrPDB Length = 361 Score = 119 bits (299), Expect = 4e-27, Method: Composition-based stats. Identities = 61/332 (18%), Positives = 115/332 (34%), Gaps = 67/332 (20%) Query: 6 NHLWLLSDILGQGATANVFRGR---HKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKL 62 ++++ + D +G+G ++V+ + A+K L P +R L+ L Sbjct: 20 SNVFKIEDKIGEGTFSSVYLATAQLQVGPEEKIALK------HLIPTSHPIRIAAELQCL 73 Query: 63 ----NHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRD 118 N++ + + H V+ M + S +L L E + + Sbjct: 74 TVAGGQDNVMGVKYCFRK--NDHVVIAMPYLEHESFLDILN------SLSFQEVREYMLN 125 Query: 119 VVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD----------- 167 + + + + GIVHRD+KP N + Y L DFG A+ D Sbjct: 126 LFKALKRIHQFGIVHRDVKPSNFLY---NRRLKKYALVDFGLAQGTHDTKIELLKFVQSE 182 Query: 168 ------------------EQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGV 209 +Q GT + P++ + + +D+WS GV Sbjct: 183 AQQERCSQNKCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQ-------TTAIDMWSAGV 235 Query: 210 TFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGPIDWSGDMPVS--C 267 F +G PF + + +I+T + S K I S ++P Sbjct: 236 IFLSLLSGRYPFYK---ASDDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLR 292 Query: 268 SLSRGLQVL--LTPVLANILEADQEKCWGFDQ 297 L L+ + TP L + ++ G+++ Sbjct: 293 KLCERLRGMDSSTPKLTSDIQGHATNLEGWNE 324 >4L00-A nrPDB Length = 304 Score = 119 bits (299), Expect = 4e-27, Method: Composition-based stats. Identities = 45/281 (16%), Positives = 103/281 (36%), Gaps = 30/281 (10%) Query: 12 SDILGQGATANVFRGR------HKKTGDLFAIKVFNNISFLRPVDV---QMREFEVLKKL 62 + LG+G +++ G + T + IKV + D+ +++++ Sbjct: 30 GEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQV 89 Query: 63 NHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGG 122 +HK+IV L+ + +++ EF G L + S+ P V + + Sbjct: 90 SHKHIVYLYGVC--VRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWK--FKVAKQLASA 145 Query: 123 MNHLRENGIVHRDIKPGNIMRV---IGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEY 179 +++L + +VH ++ N++ I + KL+D G + ++ + + Sbjct: 146 LSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERI---PW 202 Query: 180 LHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVMYKII 238 + P+ E + K D WS G T + G +P + + + + Sbjct: 203 IAPECVEDS-------KNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCR 255 Query: 239 TGKPSGAISGVQKAENGPIDWSGD-MPVSCSLSRGLQVLLT 278 PS + +++ + P ++ R + L Sbjct: 256 PVTPSCK--ELADLMTRCMNYDPNQRPFFRAIMRDINKLEE 294 >3HNG-A nrPDB Length = 360 Score = 119 bits (298), Expect = 4e-27, Method: Composition-based stats. Identities = 44/203 (21%), Positives = 73/203 (35%), Gaps = 28/203 (13%) Query: 88 FCPCGSLYTVLEEPSNAYGLPE----SEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMR 143 F SL V EE + E + + V GM L +HRD+ NI+ Sbjct: 173 FQEDKSLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILL 232 Query: 144 VIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTE---EYLHPDMYERAVLRKDHQKKYGA 200 V K+ DFG AR++ + +V T +++ P+ K Y Sbjct: 233 SENN----VVKICDFGLARDIYKNPDYVRKGDTRLPLKWMAPESIF--------DKIYST 280 Query: 201 TVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVMYKIITGK----PSGAISGV-QKAEN 254 D+WS GV + + G P+ G + +++ ++ G P + + Q + Sbjct: 281 KSDVWSYGVLLWEIFSLGGSPYP---GVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLD 337 Query: 255 GPIDWSGDMPVSCSLSRGLQVLL 277 + P L L LL Sbjct: 338 CWHRDPKERPRFAELVEKLGDLL 360 Score = 87.7 bits (216), Expect = 2e-17, Method: Composition-based stats. Identities = 24/116 (20%), Positives = 44/116 (37%), Gaps = 7/116 (6%) Query: 6 NHLWLLSDILGQGATANVFRG-----RHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLK 60 L LG+GA V + + T A+K+ + M E ++L Sbjct: 26 RERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASEYKALMTELKILT 85 Query: 61 KLNHK-NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIV 115 + H N+V L + V++ E+C G+L L+ + + L + L + Sbjct: 86 HIGHHLNVVNLLGACTKQGGPLMVIV-EYCKYGNLSNYLKSKRDLFFLNKDAALHM 140 >5FQD-C nrPDB Length = 341 Score = 117 bits (292), Expect = 2e-26, Method: Composition-based stats. Identities = 49/263 (18%), Positives = 99/263 (37%), Gaps = 33/263 (12%) Query: 2 QSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKK 61 + + L +G G+ +++ + G+ A+K+ S + E ++ K Sbjct: 14 EFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKL---ESQKARHPQLLYESKLYKI 70 Query: 62 LNH----KNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLR 117 L +I + + + VL+M+ SL + S + + L++ Sbjct: 71 LQGGVGIPHI-RWYG----QEKDYNVLVMDLL-GPSLEDLFNFCSRRFTM--KTVLMLAD 122 Query: 118 DVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQF------- 170 ++ + ++ +HRDIKP N + IG ++ L DFG A++ D+ Sbjct: 123 QMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLF-LIDFGLAKKYRDNRTRQHIPYRE 181 Query: 171 -VSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRR 229 +L GT Y + + D+ S+G + SLP++ + + Sbjct: 182 DKNLTGTARYAS--------INAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATK 233 Query: 230 NKEVMYKIITGKPSGAISGVQKA 252 K+ KI K S + + K Sbjct: 234 -KQKYEKISEKKMSTPVEVLCKG 255 >2C47-A nrPDB Length = 313 Score = 116 bits (291), Expect = 3e-26, Method: Composition-based stats. Identities = 62/304 (20%), Positives = 115/304 (37%), Gaps = 37/304 (12%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLN-HKNI 67 + + +G G + G++ T + AIK I P E+ K+L+ + + Sbjct: 6 FRVGKKIGCGNFGELRLGKNLYTNEYVAIK-LEPIKSRAPQLHL--EYRFYKQLSATEGV 62 Query: 68 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 127 +++ ++ +++E SL + + + L L++ ++ M ++ Sbjct: 63 PQVYYFGPCG--KYNAMVLELL-GPSLEDLFDLCDRTFTL--KTVLMIAIQLITRMEYVH 117 Query: 128 ENGIVHRDIKPGNIMR-VIGEDGQSVYKLTDFGAARELEDDE--------QFVSLYGTEE 178 +++RD+KP N + G Q + DFG A+E D E + SL GT Sbjct: 118 TKSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTAR 177 Query: 179 YLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKII 238 Y+ + K+ DL ++G F + GSLP++ + KE KI Sbjct: 178 YMS--------INTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKA-DTLKERYQKIG 228 Query: 239 TGKPSGAISGVQKAENGPIDWSGDMPVSCSL-------SRGLQVLLTPVLANIL-EADQE 290 K + I + EN P + + + L L+ L T + D E Sbjct: 229 DTKRATPIEVL--CENFPEEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRSGFVFDYE 286 Query: 291 KCWG 294 W Sbjct: 287 YDWA 290 >2PZI-A nrPDB Length = 681 Score = 116 bits (290), Expect = 4e-26, Method: Composition-based stats. Identities = 47/216 (21%), Positives = 86/216 (39%), Gaps = 27/216 (12%) Query: 9 WLLSDILGQGATANVFRGRHKK-TGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNI 67 + + + G ++ + G +K + + M E + L ++ H +I Sbjct: 82 YEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAERQFLAEVVHPSI 141 Query: 68 VKLFAIEEETTTRHK---VLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 124 V++F E T ++ME+ SL + S LP +E + L +++ ++ Sbjct: 142 VQIFNFVEHTDRHGDPVGYIVMEYVGGQSL-----KRSKGQKLPVAEAIAYLLEILPALS 196 Query: 125 HLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDM 184 +L G+V+ D+KP NIM + KL D GA + LYGT + P++ Sbjct: 197 YLHSIGLVYNDLKPENIMLT-----EEQLKLIDLGAVSRINSFGY---LYGTPGFQAPEI 248 Query: 185 YERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLP 220 D++++G T A T LP Sbjct: 249 VRTGP---------TVATDIYTVGRTLA-ALTLDLP 274 >4Y12-A nrPDB Length = 375 Score = 116 bits (290), Expect = 5e-26, Method: Composition-based stats. Identities = 47/216 (21%), Positives = 86/216 (39%), Gaps = 27/216 (12%) Query: 9 WLLSDILGQGATANVFRGRHKK-TGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNI 67 + + + G ++ + G +K + + M E + L ++ H +I Sbjct: 121 YEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAERQFLAEVVHPSI 180 Query: 68 VKLFAIEEETTTRHK---VLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 124 V++F E T ++ME+ SL + S LP +E + L +++ ++ Sbjct: 181 VQIFNFVEHTDRHGDPVGYIVMEYVGGQSL-----KRSKGQKLPVAEAIAYLLEILPALS 235 Query: 125 HLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDM 184 +L G+V+ D+KP NIM + KL D GA + LYGT + P++ Sbjct: 236 YLHSIGLVYNDLKPENIMLT-----EEQLKLIDLGAVSRINSFGY---LYGTPGFQAPEI 287 Query: 185 YERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLP 220 D++++G T A T LP Sbjct: 288 VRTGP---------TVATDIYTVGRTLA-ALTLDLP 313 >4NT4-A nrPDB Length = 312 Score = 115 bits (289), Expect = 6e-26, Method: Composition-based stats. Identities = 47/253 (18%), Positives = 98/253 (38%), Gaps = 31/253 (12%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKL-NH--- 64 + + +G G + G++ + AIK+ E+ K L +H Sbjct: 14 FRVGKKIGCGNFGELRLGKNLYNNEHVAIKM---EPMKSKAPQLHLEYRFYKLLGSHADN 70 Query: 65 --KNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGG 122 I +++ + R+ +++E SL + + + L L++ + ++ Sbjct: 71 APDGIPRIYHLGTCG-GRYNAMVLELL-GLSLEDLFNICARKFSL--KTVLMIAKQLLHR 126 Query: 123 MNHLRENGIVHRDIKPGNIMR-VIGEDGQSVYKLTDFGAARELEDDE--------QFVSL 173 + ++ +++RD+KP N + + + + DFG A+E D + + SL Sbjct: 127 IEYVHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHIPYREHKSL 186 Query: 174 YGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEV 233 GT Y+ + ++ DL ++G F + GSLP++ + KE Sbjct: 187 TGTARYMS--------INTHMGREQSRRDDLEALGHMFMYFLRGSLPWQGLKA-DTLKER 237 Query: 234 MYKIITGKPSGAI 246 KI K + I Sbjct: 238 YQKIGDTKRATPI 250 >5UV4-A nrPDB Length = 311 Score = 115 bits (287), Expect = 1e-25, Method: Composition-based stats. Identities = 51/290 (17%), Positives = 99/290 (34%), Gaps = 37/290 (12%) Query: 13 DILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFA 72 +I+G+ ++ G + +K F + RE + L + H N+V L Sbjct: 31 EIIGRSCHGTSYKATL-DNGYMLTVKWLKEG-FAKSKKEFSREIKKLGSVRHPNLVPLRG 88 Query: 73 IEEETTTRHKVLIMEFCPCGSLYTVLEE--PSNAYGLPESEFLIVLRDVVGGMNHLRENG 130 +++I ++ SL T L E N L + L + D+ +++L Sbjct: 89 YYWGPKEHERIMISDYADATSLSTYLSEFDERNLPPLSAGQRLNIAIDIARCLDYLHNER 148 Query: 131 IV-HRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSL--YGTEEYLHPDMYER 187 ++ H +IK N++ ++ +TD+ R + + G Y P+ Sbjct: 149 VIPHGNIKSSNVLI---QNSTPSALVTDYSLHRLMTPIGMAEQVLNAGALGYSPPEFSST 205 Query: 188 AVLRKDHQKKYGATVDLWSIGVTFYHAATGSLP----------------FRPFEGPRRNK 231 + D+++ GV TG + R + R Sbjct: 206 SKPCP------SLKSDVYAFGVILLELLTGKIAGEIICMNDGVVDLTDWVRMLDLEERVS 259 Query: 232 EVMYKIITGKPSG-----AISGVQKAENGPIDWSGDMPVSCSLSRGLQVL 276 E + ITG S A+ G+ + I + + P ++ L L Sbjct: 260 ECYDRHITGVESSEGAPQALDGMLRIALRCIRSASERPEVRTVFEDLLSL 309 >4RT7-A nrPDB Length = 415 Score = 114 bits (286), Expect = 1e-25, Method: Composition-based stats. Identities = 38/179 (21%), Positives = 64/179 (35%), Gaps = 33/179 (18%) Query: 54 REFEVLKKLNHKN---IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPES 110 RE ++ H + I L + +E+ LEE + L Sbjct: 198 REVQI-----HPDSDQISGLHGNSFHSEDE-----IEYEN----QKRLEEEEDLNVLTFE 243 Query: 111 EFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQF 170 + L V GM L VHRD+ N++ G+ V K+ DFG AR++ D + Sbjct: 244 DLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGK----VVKICDFGLARDIMSDSNY 299 Query: 171 VSLYGTE---EYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFE 225 V +++ P+ + Y D+WS G+ + + G P+ Sbjct: 300 VVRGNARLPVKWMAPESLFEGI--------YTIKSDVWSYGILLWEIFSLGVNPYPGIP 350 Score = 94.7 bits (234), Expect = 1e-19, Method: Composition-based stats. Identities = 27/115 (23%), Positives = 42/115 (36%), Gaps = 8/115 (6%) Query: 4 TSNHLWLLSDILGQGATANVFRGRH---KKTGD--LFAIKVFNNISFLRPVDVQMREFEV 58 +LG GA V KTG A+K+ + + M E ++ Sbjct: 62 FPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKM 121 Query: 59 LKKL-NHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEF 112 + +L +H+NIV L T + LI E+C G L L + +E Sbjct: 122 MTQLGSHENIVNLLGAC--TLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEI 174 >1CSN-A nrPDB Length = 298 Score = 114 bits (286), Expect = 1e-25, Method: Composition-based stats. Identities = 50/277 (18%), Positives = 104/277 (37%), Gaps = 29/277 (10%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNH-KNI 67 + + +G+G+ +F G + AIK S + + R +++L N+ Sbjct: 12 YKVGRRIGEGSFGVIFEGTNLLNNQQVAIKFEPRRSDAPQLRDEYRTYKLLAGCTGIPNV 71 Query: 68 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 127 + +E H VL+++ SL +L+ + + ++ + + Sbjct: 72 ---YYFGQEG--LHNVLVIDLL-GPSLEDLLDLCGR--KFSVKTVAMAAKQMLARVQSIH 123 Query: 128 ENGIVHRDIKPGNIMR-VIGEDGQSVYKLTDFGAARELEDD--------EQFVSLYGTEE 178 E +V+RDIKP N + ++ + DFG + D + +L GT Sbjct: 124 EKSLVYRDIKPDNFLIGRPNSKNANMIYVVDFGMVKFYRDPVTKQHIPYREKKNLSGTAR 183 Query: 179 YLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKII 238 Y+ + ++ DL ++G F + GSLP++ + NK+ +I Sbjct: 184 YMS--------INTHLGREQSRRDDLEALGHVFMYFLRGSLPWQGLKA-ATNKQKYERIG 234 Query: 239 TGKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQV 275 K S + + P ++ M + +L+ Sbjct: 235 EKKQSTPLREL--CAGFPEEFYKYMHYARNLAFDATP 269 >4XHH-A nrPDB Length = 403 Score = 112 bits (281), Expect = 5e-25, Method: Composition-based stats. Identities = 50/289 (17%), Positives = 99/289 (34%), Gaps = 39/289 (13%) Query: 1 MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLK 60 M + + +G G+ +++ G + +G+ AI S E V K Sbjct: 1 MDLRVGRKFRIGRKIGSGSFGDIYHGTNLISGEEVAI---RLESIRSRHPQLDYESRVYK 57 Query: 61 KLNH----KNIVKLFAIEEETTTRHKVLIMEFC--PCGSLYTVLEEPSNAYGLPESEFLI 114 L+ I + F + ++++ L+ ++ Sbjct: 58 YLSGGVGIPFI-RWFG----REGEYNAMVIDLLGPSLEDLFNYCHRK-----FSFKTVIM 107 Query: 115 VLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQF---- 170 + ++ + ++ +HRDIKP N + +G G + DFG +++ D Sbjct: 108 LALQMICRVQYIHGRSFIHRDIKPDNFLMGVGRRGS-TVHVIDFGLSKKYRDFNTHRHIP 166 Query: 171 ----VSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEG 226 SL GT Y + + DL S+G + GSLP++ + Sbjct: 167 YRENKSLTGTARYAS--------VNTHLGIEQSRRDDLESLGYMLIYFCKGSLPWQGLKA 218 Query: 227 PRRNKEVMYKIITGKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQV 275 + K+ +I+ K IS P+++S M +L + Sbjct: 219 TTK-KQKYDRILEKK--LCISVETLCAGLPLEFSEYMNYCRNLKFDERP 264 >5M07-A nrPDB Length = 276 Score = 111 bits (278), Expect = 9e-25, Method: Composition-based stats. Identities = 44/214 (20%), Positives = 81/214 (37%), Gaps = 26/214 (12%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRP--VDVQMREFEVLKKLNHKN 66 + + +LG A V+ +H A+KV + RE EV +L H + Sbjct: 32 YTVVRMLGASAMGEVYLVQHPGFPGWQALKVLSPAMAADDEFRRRFQRETEVAARLFHPH 91 Query: 67 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 126 I+++ E + M++ + + A LP E L ++ V G +++ Sbjct: 92 ILEVHDRGEF--DGQLWIAMDYVDGIDATQHMADRFPAV-LPVGEVLAIVTAVAGALDYA 148 Query: 127 RENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYE 186 + G++HRD+ P N++ G L DFG A + Y P++ Sbjct: 149 HQRGLLHRDVNPANVVLTSQSAGDQRILLADFGIASQ-------------PSYPAPELSA 195 Query: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLP 220 A + D +++ +T H G+ P Sbjct: 196 GADV--------DGRADQYALALTAIHLFAGAPP 221 >5L2Q-C nrPDB Length = 320 Score = 109 bits (272), Expect = 5e-24, Method: Composition-based stats. Identities = 49/252 (19%), Positives = 88/252 (34%), Gaps = 48/252 (19%) Query: 24 FRGRHKKTGDLFAIKV----------FNNISFLRPVDVQMREFEVLKKLN-HKNIVKLFA 72 R T D + +K+ + + + E+ +L L+ +V Sbjct: 33 CLARKDGTDDFYQLKILTLEERGDQGIESQEERQGKMLLHTEYSLLSLLHTQDGVVHHHG 92 Query: 73 IEEETT----------------TRHKVLIME-FCPCG------SLYTVLEEPSNAYGLPE 109 + ++ T + L+++ C L + L E Sbjct: 93 LFQDRTCEIVEDTESSRMVKKMKKRICLVLDCLCAHDFSDKTADLINLQHYVIKEKRLSE 152 Query: 110 SEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAAREL-EDDE 168 E +++ DVV + L + IVHRD+K GN++ +T+F + L + + Sbjct: 153 RETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVL---NKRTHRITITNFCLGKHLVSEGD 209 Query: 169 QFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFR---PFE 225 G+ Y+ PD+ R G D+W++GV + G PF P E Sbjct: 210 LLKDQRGSPAYISPDVLSGRPYR-------GKPSDMWALGVVLFTMLYGQFPFYDSIPQE 262 Query: 226 GPRRNKEVMYKI 237 R+ K Y I Sbjct: 263 LFRKIKAAEYTI 274 >5C01-A nrPDB Length = 342 Score = 107 bits (267), Expect = 2e-23, Method: Composition-based stats. Identities = 39/256 (15%), Positives = 80/256 (31%), Gaps = 21/256 (8%) Query: 26 GRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIEEETTTRHKVLI 85 GR + +KV + S ++ +++H ++ + + +++ Sbjct: 101 GRDRGQELRVVLKVLDP-SHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGP--ENIMV 157 Query: 86 MEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRV- 144 E+ G L L + V + + +++L +VH ++ NI+ Sbjct: 158 TEYVEHGPLDVWLRRERGHVPMAWKMV--VAQQLASALSYLENKNLVHGNVCGRNILLAR 215 Query: 145 --IGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATV 202 + E KL+D G E+ V +L P+ + Sbjct: 216 LGLAEGTSPFIKLSDPGVGLGALSREERVERI---PWLAPECLPGGANSL------STAM 266 Query: 203 DLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGPIDWSG 261 D W G T G P + KE Y+ P + + + + + Sbjct: 267 DKWGFGATLLEICFDGEAPLQSRSPSE--KEHFYQRQHRLPEPSCPQLATLTSQCLTYEP 324 Query: 262 -DMPVSCSLSRGLQVL 276 P ++ R L L Sbjct: 325 TQRPSFRTILRDLTRL 340 >4WOV-A nrPDB Length = 317 Score = 106 bits (266), Expect = 3e-23, Method: Composition-based stats. Identities = 39/256 (15%), Positives = 80/256 (31%), Gaps = 21/256 (8%) Query: 26 GRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIEEETTTRHKVLI 85 GR + +KV + S ++ +++H ++ + + +++ Sbjct: 78 GRDRGQELRVVLKVLDP-SHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGP--ENIMV 134 Query: 86 MEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRV- 144 E+ G L L + V + + +++L +VH ++ NI+ Sbjct: 135 TEYVEHGPLDVWLRRERGHVPMAWKMV--VAQQLASALSYLENKNLVHGNVCGRNILLAR 192 Query: 145 --IGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATV 202 + E KL+D G E+ V +L P+ + Sbjct: 193 LGLAEGTSPFIKLSDPGVGLGALSREERVERI---PWLAPECLPGGANSL------STAM 243 Query: 203 DLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGPIDWSG 261 D W G T G P + KE Y+ P + + + + + Sbjct: 244 DKWGFGATLLEICFDGEAPLQSRSPSE--KEHFYQRQHRLPEPSCPQLATLTSQCLTYEP 301 Query: 262 -DMPVSCSLSRGLQVL 276 P ++ R L L Sbjct: 302 TQRPSFRTILRDLTRL 317 >4XHL-A nrPDB Length = 394 Score = 106 bits (264), Expect = 4e-23, Method: Composition-based stats. Identities = 46/289 (15%), Positives = 99/289 (34%), Gaps = 39/289 (13%) Query: 1 MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLK 60 M + + +G G+ +++ G + +G+ AI S E V + Sbjct: 1 MDLRVGRKFRIGRKIGSGSFGDIYHGTNLISGEEVAI---RLESIRSRHPQLDYESRVYR 57 Query: 61 KLNH----KNIVKLFAIEEETTTRHKVLIMEFC--PCGSLYTVLEEPSNAYGLPESEFLI 114 L+ I + F + ++++ L+ ++ Sbjct: 58 YLSGGVGIPFI-RWFG----REGEYNAMVIDLLGPSLEDLFNYCHRR-----FSFKTVIM 107 Query: 115 VLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQF---- 170 + + + ++ +HRDIKP N + +G G + DFG +++ D Sbjct: 108 LALQMFCRIQYIHGRSFIHRDIKPDNFLMGVGRRGS-TVHVIDFGLSKKYRDFNTHRHIP 166 Query: 171 ----VSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEG 226 SL GT Y + + DL S+G + GSLP++ + Sbjct: 167 YRENKSLTGTARYAS--------VNTHLGIEQSRRDDLESLGYVLIYFCKGSLPWQGLKA 218 Query: 227 PRRNKEVMYKIITGKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQV 275 + K+ +I+ K + ++ + P+++ M +L + Sbjct: 219 TTK-KQKYDRIMEKKLNVSVETLCSG--LPLEFQEYMAYCKNLKFDEKP 264 >5X1R-A nrPDB Length = 302 Score = 105 bits (263), Expect = 5e-23, Method: Composition-based stats. Identities = 48/259 (18%), Positives = 96/259 (37%), Gaps = 36/259 (13%) Query: 7 HLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDV--------------- 51 + + + + +G+G V+R + AIK + S + D Sbjct: 21 NEFEIQEAIGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAKRNDDLSIGLRGERFGKTFQ 80 Query: 52 -----QMREFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYG 106 ++E +L + +H ++ + EE T + +F +L + + Sbjct: 81 AGLNSFIQEARLLARFSHPGLLHVLRFWEENGT--AYMGTQFYSGTTLKNL--QAQQPEK 136 Query: 107 LPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAAR-ELE 165 + E+ +L + +N + + G +HRDI NI I E V L DFG+AR E+ Sbjct: 137 IDEAWIRRLLPPLFSAINTIHQEGYLHRDISLDNI--QIQESQLPV--LLDFGSARKEIG 192 Query: 166 DDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFE 225 + + + + Y + G D++++G + GS P P Sbjct: 193 NLSDETEIVLKPGFAPIEQYTENSDGEQ-----GPWTDIYALGAVLHTLIVGSPP--PVS 245 Query: 226 GPRRNKEVMYKIITGKPSG 244 R ++ + +P+G Sbjct: 246 VVRSIEDSYQPLTERRPAG 264 >5OAT-A nrPDB Length = 411 Score = 98.5 bits (244), Expect = 1e-20, Method: Composition-based stats. Identities = 51/278 (18%), Positives = 90/278 (32%), Gaps = 63/278 (22%) Query: 11 LSDILGQGATANVF--RGRHKKTGD---LFAIKVFNNISFLRPVDVQMR----------- 54 L + +G V+ + + +T D FA+K+ N ++ Sbjct: 15 LGKPIAKGTNGVVYSAKVKDDETDDNKYPFALKMMFNYDIQENSMEILKAMYRETVPARM 74 Query: 55 ----------EFEVLKKLNH----KNIVKLFAIEEE---------------TTTRHKVLI 85 E E+ + H NIV +F++ + L+ Sbjct: 75 YYSNHDLNNWEIELANRRKHLPPHPNIVAIFSVFTDLYPAALPPRLHPEGEGRNMSLFLL 134 Query: 86 MEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVI 145 M+ C +L + L + + + G+ H+ +GI HRD+K N++ Sbjct: 135 MKRYDC-NLQSFLSTAPSTRTSLLLLAQL-----LEGVAHMTAHGIAHRDLKSDNLLLDT 188 Query: 146 GEDGQSVYKLTDFGAARE-------LEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKY 198 E + ++DFG L + G + P++ + Y Sbjct: 189 SEPESPILVISDFGCCLADKTNGLSLPYTSYEMDKGGNTALMAPEIICQKP-GTFSVLNY 247 Query: 199 GATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYK 236 DLW++G Y PF GP R K YK Sbjct: 248 S-KADLWAVGAIAYEIFNCHNPFY---GPSRLKNFNYK 281 >5CEK-A nrPDB Length = 263 Score = 95.8 bits (237), Expect = 6e-20, Method: Composition-based stats. Identities = 50/265 (18%), Positives = 89/265 (33%), Gaps = 27/265 (10%) Query: 23 VFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIEEETTTRHK 82 V R TG KVF + + ++ +H NI + + T + Sbjct: 25 VSRALCIHTGRELRCKVFPIKHYQDKIRPYIQ------LPSHSNITGIVEVILGETKAYV 78 Query: 83 VLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIM 142 +F G +++ + L E E + + +V + H ++ IV D+K + Sbjct: 79 FFEKDF---GDMHSYVRSRKR---LREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFV 132 Query: 143 RVIGEDGQSVY-KLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGAT 201 E Q L D + +D+ +G Y+ P++ G Sbjct: 133 FSTEERTQLRLESLEDTHIMK--GEDDALSDKHGCPAYVSPEILNTTGTYS------GKA 184 Query: 202 VDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGPIDWSG 261 D+WS+GV Y G PF + + KI G+ I + + S Sbjct: 185 ADVWSLGVMLYTLLVGRYPFHDSDP----SALFSKIRRGQF--CIPEHISPKARCLIRSL 238 Query: 262 DMPVSCSLSRGLQVLLTPVLANILE 286 ++LL P ++LE Sbjct: 239 LRREPSERLTAPEILLHPWFESVLE 263 >6DC0-A nrPDB Length = 292 Score = 95.8 bits (237), Expect = 7e-20, Method: Composition-based stats. Identities = 50/265 (18%), Positives = 89/265 (33%), Gaps = 27/265 (10%) Query: 23 VFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIEEETTTRHK 82 V R TG KVF + + ++ +H NI + + T + Sbjct: 22 VSRALCIHTGRELRCKVFPIKHYQDKIRPYIQ------LPSHSNITGIVEVILGETKAYV 75 Query: 83 VLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIM 142 +F G +++ + L E E + + +V + H ++ IV D+K + Sbjct: 76 FFEKDF---GDMHSYVRSRKR---LREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFV 129 Query: 143 RVIGEDGQSVY-KLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGAT 201 E Q L D + +D+ +G Y+ P++ G Sbjct: 130 FSTEERTQLRLESLEDTHIMK--GEDDALSDKHGCPAYVSPEILNTTGTYS------GKA 181 Query: 202 VDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGPIDWSG 261 D+WS+GV Y G PF + + KI G+ I + + S Sbjct: 182 ADVWSLGVMLYTLLVGRYPFHDSDP----SALFSKIRRGQF--CIPEHISPKARCLIRSL 235 Query: 262 DMPVSCSLSRGLQVLLTPVLANILE 286 ++LL P ++LE Sbjct: 236 LRREPSERLTAPEILLHPWFESVLE 260 >4L68-A nrPDB Length = 340 Score = 95.4 bits (236), Expect = 8e-20, Method: Composition-based stats. Identities = 38/205 (18%), Positives = 68/205 (33%), Gaps = 27/205 (13%) Query: 21 ANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIEEETTTR 80 ++ G A+K + E L +L H N+ L Sbjct: 54 GTTYKALL-PDGSALAVKHLSTCKLGER--EFRYEMNQLWELRHSNLAPLLGFC--VVEE 108 Query: 81 HKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE---NGIVHRDIK 137 K L+ ++ G+L+++L+ SN L S + G+ L I+H++I Sbjct: 109 EKFLVYKYMSNGTLHSLLD--SNRGELDWSTRFRIGLGAARGLAWLHHGCRPPILHQNIC 166 Query: 138 PGNIMRVIGEDGQSVYKLTDFGAARELEDDEQ-----FVSLYGTEEYLHPDMYERAVLRK 192 I+ D ++ D G AR + + G Y+ P+ + Sbjct: 167 SSVILIDEDFDA----RIIDSGLARLMVPSDNNESSFMTGDLGEFGYVAPEYSTTMLA-- 220 Query: 193 DHQKKYGATVDLWSIGVTFYHAATG 217 D++ +GV ATG Sbjct: 221 ------SLKGDVYGLGVVLLELATG 239 >6EQI-C nrPDB Length = 433 Score = 93.9 bits (232), Expect = 2e-19, Method: Composition-based stats. Identities = 50/338 (14%), Positives = 100/338 (29%), Gaps = 69/338 (20%) Query: 1 MQSTSNHLWLLSDILGQGATANVFRGRHKKTG-----DLFAIKVFNNISFLRPVDVQM-- 53 +Q+ + L + + +G A V+ + K A+K+ N + Sbjct: 9 LQAANLDELDLGEPIAKGCNAVVYSAKLKNVQSNKLAHQLAVKMMFNYDVESNSTAILKA 68 Query: 54 --RE---------------FEVLKKLN-----HKNIVKLFAIEEETTTR----------- 80 RE E + H NIV+++++ + Sbjct: 69 MYRETVPAMSYFFNQNLFNIENISDFKIRLPPHPNIVRMYSVFADRIPDLQCNKQLYPEA 128 Query: 81 --------------HKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 126 L+M+ C +L L + + +L + H+ Sbjct: 129 LPPRINPEGSGRNMSLFLVMKRYDC-TLKEYLRDKTPNMRSSILLLSQLL----EAVAHM 183 Query: 127 RENGIVHRDIKPGNIMRVIGE-DGQSVYKLTDFGAARE-------LEDDEQFVSLYGTEE 178 + I HRD+K NI+ + E D +TDFG + + G Sbjct: 184 NIHNISHRDLKSDNILVDLSEGDAYPTIVITDFGCCLCDKQNGLVIPYRSEDQDKGGNRA 243 Query: 179 YLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKII 238 + P++ DLW++G Y PF +K + + Sbjct: 244 LMAPEIANAKPGTFSWLNY--KKSDLWAVGAIAYEIFNIDNPFYDKTMKLLSKSYKEEDL 301 Query: 239 TGKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVL 276 P ++ + + S + + C ++ + L Sbjct: 302 PELPDTIPFIIRNLVSNMLSRSTNKRLDCDVAATVAQL 339 >6J6I-B nrPDB Length = 351 Score = 88.9 bits (219), Expect = 6e-18, Method: Composition-based stats. Identities = 41/201 (20%), Positives = 76/201 (37%), Gaps = 28/201 (13%) Query: 32 GDLFAIKVFNNISFLRPVDVQMREF---EVL--KKLNHKNIVKLFAIEEETTTRHKVLIM 86 + IK F+ +++E VL + NH N ++L E VL+ Sbjct: 81 DRSYMIKRFSEDEITGKR-HRVKEVYNDIVLSARMSNHSNFLQLLGCCLE--FPFPVLVF 137 Query: 87 EFCPCGSLYTV--LEEPSNAYGLPESEFLIVLRDVVGGMNHLRE---NGIVHRDIKPGNI 141 EF G++ + LP S L + +++ + +L I+HRD+KP ++ Sbjct: 138 EFAEHGAMNQRGGVIVNGEESLLPWSVRLKIGKEIANAVTYLHTAFPKIIIHRDVKPMHV 197 Query: 142 MRVIGEDGQSVYKLTDFGAARELEDDEQFVS---LYGTEEYLHPDMYERAVLRKDHQKKY 198 D KL+D + L + + + + GT Y+ P ++ + Sbjct: 198 FL----DKNWTAKLSDLSFSISLPEGKSRIEAEWVLGTFGYIDPLYHKTCFV-------- 245 Query: 199 GATVDLWSIGVTFYHAATGSL 219 D++S G+ TG Sbjct: 246 TEYTDVYSFGICLLVIITGKP 266 >5CLR-A nrPDB Length = 451 Score = 87.0 bits (214), Expect = 3e-17, Method: Composition-based stats. Identities = 43/200 (21%), Positives = 70/200 (35%), Gaps = 22/200 (11%) Query: 24 FRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIEEETTTRHKV 83 F+ G + +K + E + L KL +L T+ Sbjct: 96 FKVYALDDGKTYFLKSVK--IDAESLTEFTNEKDTLSKLG-----RLVGTFFNEQTQVHY 148 Query: 84 LIMEFCPCGSLYTVLEEPSNAYGLPES-EFLIVLRDVVGGMNHLRENGIVHRDIKPGNIM 142 ++ F L L E L ++ V + E G++HRD+KPGNIM Sbjct: 149 ILTTFIKGIDLSRYKNALPLNVNLKHFWEVLGIMISVCHQVKQFHELGLIHRDLKPGNIM 208 Query: 143 RVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATV 202 D L DFG++ D E + +GT YL P++ + + Sbjct: 209 L----DADMQCHLVDFGSSS--SDKEPKPASWGTASYLAPELNAQEDFIA-----FSQVS 257 Query: 203 DLWSIGVTFYHAATGSLPFR 222 DL+++ + PFR Sbjct: 258 DLFALAYSLDELFN---PFR 274 >4I94-A nrPDB Length = 300 Score = 85.4 bits (210), Expect = 7e-17, Method: Composition-based stats. Identities = 39/266 (14%), Positives = 88/266 (33%), Gaps = 27/266 (10%) Query: 22 NVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIEEETTTRH 81 V++G+ + A+K FN S+ + E + + +L + + L E R Sbjct: 44 VVYKGKL-ENQRRIAVKRFNRKSWPDSRQ-FLEEAKAVGQLRNHRMANLLGCCYEDEER- 100 Query: 82 KVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG-IVHRDIKPGN 140 +LI EF P +L L + + + L V + + + G ++ D+ Sbjct: 101 -LLIAEFMPNETLAKHLF-HWESQPMKWAMRLRVALHIAQALEYCTSKGRALYHDLNAYR 158 Query: 141 IMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGA 200 ++ + + FG + D + + + + P+ + Sbjct: 159 VLFDDDANPRLSC----FGLMKNSRDGKSYST---NLAFTPPEYLRTGRV--------TP 203 Query: 201 TVDLWSIGVTFYHAATGS--LPFRPFEGPRRNKEVMYKI--ITGKPSGAI-SGVQKAENG 255 ++S G +G P + R M + G+ S + + + + Sbjct: 204 ESVIYSFGTLLLDLLSGKHIPPSHALDLIRDRNIQMLMDSGLEGQFSSDDGTELIRLASR 263 Query: 256 PIDWSG-DMPVSCSLSRGLQVLLTPV 280 + + + P SL + L + Sbjct: 264 CLQYEPRERPNPKSLVSAMIPLQKDL 289 >4JRN-A nrPDB Length = 372 Score = 85.4 bits (210), Expect = 8e-17, Method: Composition-based stats. Identities = 42/239 (17%), Positives = 73/239 (30%), Gaps = 47/239 (19%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVF--NNISFLRPVDVQMREFEVLKKLN--------- 63 LG G A V+ +T + A+KVF + RE + + Sbjct: 76 LGSGGFATVYEATDVETNEELAVKVFMSEKEPTDETMLDLQRESSCYRNFSLAKTAKDAQ 135 Query: 64 --HKNIVK---------------LFAIEEETTTRHKVLIMEFCPCGSLYTVL-----EEP 101 + +V + + + +L+M + V+ + Sbjct: 136 ESCRFMVPSDVVMLEGQPASTEVVIGLTTRWVPNYFLLMMRAEA--DMSKVISWVFGDAS 193 Query: 102 SNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAA 161 N + + + + +++ GIVH DIKP N + + L DFG Sbjct: 194 VNKSEFGLVVRMYLSSQAIKLVANVQAQGIVHTDIKPANFLLL----KDGRLFLGDFG-- 247 Query: 162 RELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLP 220 + GT Y P+ +A Y D W +G+T Y P Sbjct: 248 -TYRINNSVGRAIGTPGYEPPERPFQAT-----GITYTFPTDAWQLGITLYCIWCKERP 300 >5UU1-A nrPDB Length = 324 Score = 81.2 bits (199), Expect = 2e-15, Method: Composition-based stats. Identities = 40/274 (14%), Positives = 82/274 (29%), Gaps = 32/274 (11%) Query: 4 TSNHLWLLSDILGQGATANVFRGRHKKTGDLFA---IKVFNNISFLRPVDVQMREFEVLK 60 + W+L +G G ++ + A +KV + E + + Sbjct: 13 MEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKV-----EYQENGPLFSELKFYQ 67 Query: 61 KLNHKNIVK--------------LF---AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSN 103 ++ K+ +K LF + E ++ ++ME L + Sbjct: 68 RVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERL-GIDLQKI---SGQ 123 Query: 104 AYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARE 163 +S L + ++ + ++ EN VH DIK N++ Q L D+G + Sbjct: 124 NGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVY--LADYGLSYR 181 Query: 164 LEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF-R 222 + H E L D+ +G G LP+ + Sbjct: 182 YCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQ 241 Query: 223 PFEGPRRNKEVMYKIITGKPSGAISGVQKAENGP 256 + P + ++ P + + Sbjct: 242 NLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCC 275 >5DMZ-A nrPDB Length = 365 Score = 75.4 bits (184), Expect = 9e-14, Method: Composition-based stats. Identities = 43/231 (18%), Positives = 82/231 (35%), Gaps = 32/231 (13%) Query: 6 NHLWLLSDILGQGATANVFRGR-----HKKTGDLFAIKVFNNISFLR-PVDVQMREFEVL 59 + L + +LG+GA A V+ K F +KV + + Q+ E L Sbjct: 64 SKLVYVHHLLGEGAFAQVYEATQGDLNDAKNKQKFVLKVQKPANPWEFYIGTQLMER--L 121 Query: 60 K-KLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLE--EPSNAYGLPESEFLIVL 116 K + H +K ++ VL+ E G+L + + + +P+ + Sbjct: 122 KPSMQHMF-MKFYSAHLFQNGS--VLVGELYSYGTLLNAINLYKNTPEKVMPQGLVISFA 178 Query: 117 RDVVGGMNHLRENGIVHRDIKPGNIMRVIG-------EDGQSVYKLTDFGAA---RELED 166 ++ + + + I+H DIKP N + G +D + L D G + + Sbjct: 179 MRMLYMIEQVHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMKLFPK 238 Query: 167 DEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATG 217 F + T + +M K + +D + + T Y G Sbjct: 239 GTIFTAKCETSGFQCVEMLS--------NKPWNYQIDYFGVAATVYCMLFG 281 >4IX6-A nrPDB Length = 350 Score = 73.9 bits (180), Expect = 3e-13, Method: Composition-based stats. Identities = 48/241 (19%), Positives = 74/241 (30%), Gaps = 45/241 (18%) Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLN-HKN----IVK 69 LG G VFRG K D+ N ++ E E+ + H N + Sbjct: 28 LGSGNFGTVFRGVFKGDQDVV----LKNAKADVMAAEELLECEMDVNYHVHANAKGTCAR 83 Query: 70 LFAIEE----ETTTRHKVLIME---FCPCGSLYTVLEEPSNAYGLPESEFLIV------- 115 E + + + E +E P + + Sbjct: 84 FMGCIELGAKDGGEIYNGTLTEGLWLMWANEGENTVEALMRRGTAPLATAMACADATELG 143 Query: 116 -----LRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFG---AARELEDD 167 +R+++G + L E G+VHRD+KP N + +DG V KL D G L + Sbjct: 144 VTKKAMRELLGSLARLHECGVVHRDVKPAN-LIAAEKDG-GVLKLIDLGAAALCLPLPET 201 Query: 168 EQFVSLYGT--EEY-LHPDMYERAVLRKDHQKKYGATV---------DLWSIGVTFYHAA 215 + G Y ++Y K A + D WS G A Sbjct: 202 LNYYPGDGPADPRYAKADELYLLPPGSPRPTKDNAAKLWEAHKPDRFDSWSAGCVMLQLA 261 Query: 216 T 216 Sbjct: 262 V 262 >2LAV-A nrPDB Length = 361 Score = 70.4 bits (171), Expect = 3e-12, Method: Composition-based stats. Identities = 46/298 (15%), Positives = 95/298 (31%), Gaps = 28/298 (9%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDL-----FAIKV-----------FNNISFLRPVDVQ 52 W + +GQG ++ + + +KV + Sbjct: 37 WKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQI 96 Query: 53 MREFEVLKKLNHKNIVKLFA--IEEETTTRHKVLIME-FCPCGSLYTVLEEPSNAYGLPE 109 + +KL + + K + + ++ ++ +IM+ F L + E NA Sbjct: 97 QKWIRT-RKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF--GSDLQKIYEA--NAKRFSR 151 Query: 110 SEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQ 169 L + ++ + ++ E+ VH DIK N++ Q L D+G A + Sbjct: 152 KTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVY--LVDYGLAYRYCPEGV 209 Query: 170 FVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRP-FEGPR 228 + H E + + DL +G TG LP+ + P+ Sbjct: 210 HKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPK 269 Query: 229 RNKEVMYKIITGKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILE 286 ++ + S +N P + + M L + L + +L+ Sbjct: 270 YVRDSKIRYRENIASLM-DKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDILLQ 326 >2RSV-A nrPDB Length = 403 Score = 70.4 bits (171), Expect = 3e-12, Method: Composition-based stats. Identities = 46/298 (15%), Positives = 95/298 (31%), Gaps = 28/298 (9%) Query: 9 WLLSDILGQGATANVFRGRHKKTGDL-----FAIKV-----------FNNISFLRPVDVQ 52 W + +GQG ++ + + +KV + Sbjct: 44 WKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQI 103 Query: 53 MREFEVLKKLNHKNIVKLFA--IEEETTTRHKVLIME-FCPCGSLYTVLEEPSNAYGLPE 109 + +KL + + K + + ++ ++ +IM+ F L + E NA Sbjct: 104 QKWIRT-RKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF--GSDLQKIYEA--NAKRFSR 158 Query: 110 SEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQ 169 L + ++ + ++ E+ VH DIK N++ Q L D+G A + Sbjct: 159 KTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVY--LVDYGLAYRYCPEGV 216 Query: 170 FVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRP-FEGPR 228 + H E + + DL +G TG LP+ + P+ Sbjct: 217 HKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPK 276 Query: 229 RNKEVMYKIITGKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILE 286 ++ + S +N P + + M L + L + +L+ Sbjct: 277 YVRDSKIRYRENIASLM-DKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDILLQ 333 >6EAS-A nrPDB Length = 308 Score = 69.6 bits (169), Expect = 5e-12, Method: Composition-based stats. Identities = 49/227 (21%), Positives = 87/227 (38%), Gaps = 33/227 (14%) Query: 11 LSDILGQGATANVFRGRHKKTGDLFAIK---VFNNISFLRPVDVQMRE-FEVLKKLNHKN 66 S+I+G +T +++G +G A+ V + + + + Q R+ L K++HKN Sbjct: 44 FSNIIGSTSTCMLYKGTL-SSGVEIAVASSLVTSAKDWSKENESQYRKKITNLSKVSHKN 102 Query: 67 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 126 + L EE +V++ E+ P G+L+ L A L L + + + H+ Sbjct: 103 FMNLLGYCEEEHPFTRVMVFEYAPNGTLFEHLH-VREAEKLDWMARLRISMGIAYCLEHM 161 Query: 127 RENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYG---TEEYLHPD 183 + N D +VY DF A ++ D E + G T + Sbjct: 162 HQLQTP---AALRNF------DSTTVYLTDDF--AAKVSDLEFWNDAKGHNSTTN----N 206 Query: 184 MYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRN 230 + +D +KY G+ TG +P +GP N Sbjct: 207 ELAFSPDMEDIVRKY---------GMVLLEILTGRVPSSEDDGPLEN 244 >6G4J-A nrPDB Length = 315 Score = 68.1 bits (165), Expect = 1e-11, Method: Composition-based stats. Identities = 27/183 (14%), Positives = 62/183 (33%), Gaps = 24/183 (13%) Query: 5 SNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNH 64 + + + L LG+GA V+ + A+KV ++ + E VLK + Sbjct: 24 NGNTYTLRKQLGKGANGIVYLAE--TSDGHVALKVSDDSLSIT------SEVNVLKSFSK 75 Query: 65 KNIVKLFAIEEETTTRHK--------VLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVL 116 V + +T + ME+ L + + +++ Sbjct: 76 AQSVTMGPSFFDTDDAYIPSANTKVSFYAMEYIKGPLLLKYVSDKGA------EWIPVLM 129 Query: 117 RDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGT 176 ++ ++ L + G + D+KP N++ + G +E +++ Y Sbjct: 130 IQLLSSLSVLHQQGWIFGDLKPDNLIVTGPPARIRCIDVG--GTTKEGRAIKEYTEFYDR 187 Query: 177 EEY 179 + Sbjct: 188 GYW 190 >5GZA-A nrPDB Length = 290 Score = 66.9 bits (162), Expect = 3e-11, Method: Composition-based stats. Identities = 40/217 (18%), Positives = 72/217 (33%), Gaps = 41/217 (18%) Query: 12 SDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLF 71 ++GQGA V+ + G A+ V S + D + +L+ L ++V L Sbjct: 30 VKLIGQGAVKKVYLSEWQ--GQKVALSVL---SSDQYADDFLHGLSMLRALQSSHVVTLV 84 Query: 72 AIEEETTTRHKVLIMEFCPCGS---LYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE 128 + EE V + E+ P GS L T L + + L + D V + +L Sbjct: 85 GVCEED----AVFVTEYHPLGSVLTLDTTLAQERYRWRNSWHTRLQLAIDYVAFLAYLHS 140 Query: 129 NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELE------------DDEQFVSLYG- 175 + P I + + L+ F A ++ + G Sbjct: 141 S--------PAGIRVMCDSN-DLHKTLSQFLLASDMRLLANDLDALPEVEKGGLGVKCGH 191 Query: 176 ---TEEYLHPDMY----ERAVLRKDHQKKYGATVDLW 205 T +++ P+ E + Y D+W Sbjct: 192 HELTGDFVAPEQLWPYGEDFSFSDEAMPGYDEKTDIW 228 >5GZ9-A nrPDB Length = 305 Score = 65.0 bits (157), Expect = 1e-10, Method: Composition-based stats. Identities = 40/208 (19%), Positives = 74/208 (35%), Gaps = 24/208 (11%) Query: 13 DILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFA 72 +G+GA VF K+ A + ++ L + + ++LK L +++V L Sbjct: 40 KRVGEGAVKRVFLSEWKE--HKVA---LSRLTRLEMKEDFLHGLQMLKSLQSEHVVTLVG 94 Query: 73 IEEETTTRHKVLIMEFCPCGSLYTV---LEEPSNAYGLPESEFLIVLRDVVGGMNHLREN 129 EE T ++ E+ P GSL + L+ L + + V +N+L + Sbjct: 95 YCEEDGT----ILTEYHPLGSLSNLEETLQLSKYQDVNTWQHRLQLAMEYVSIINYLHHS 150 Query: 130 GIVHRDIKPGNIMRVIGED----GQSVYKLTDFGAARELEDDEQFVSLYGTEE----YLH 181 + R + N + D A ++ D + G E ++ Sbjct: 151 PLGTRVMCDSNDLPKTLSQYLLTSNFSIVANDLDALPLVDHDSGVLIKCGHRELHGDFVA 210 Query: 182 PDMY----ERAVLRKDHQKKYGATVDLW 205 P+ E + D Y VD+W Sbjct: 211 PEQLWPYGEDTPFQDDLMPSYNEKVDIW 238 >4O1O-A nrPDB Length = 717 Score = 63.9 bits (154), Expect = 3e-10, Method: Composition-based stats. Identities = 32/173 (18%), Positives = 68/173 (39%), Gaps = 23/173 (13%) Query: 1 MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLK 60 ++ + + ++D A ++ G ++ A+K F+ S +E L+ Sbjct: 344 LKIFIDEEYKIADT----AEGGIYLGLYED--QEVAVKRFSEGSTRGQ-----QEVSCLQ 392 Query: 61 KLN-HKNIVKLFAIEEETTTRHKVLIM-EFCPCGSLYTVLEEPSNAYGLPESE--FLIVL 116 + N+V + E + + H L + E+ +L L E + +L Sbjct: 393 SSRANDNVVTFYGSESDGSCLHVCLALCEY----TLQEHLANHRGDAVPNEEDESARNIL 448 Query: 117 RDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQ 169 + + L +G H+D++P NI+ D ++ L DF + + +D Q Sbjct: 449 SSLFKAIGELHRSGYSHQDLQPQNILI----DSKNGTFLADFDKSIKWAEDPQ 497 >4CI6-B nrPDB Length = 643 Score = 60.0 bits (144), Expect = 3e-09, Method: Composition-based stats. Identities = 43/242 (17%), Positives = 76/242 (31%), Gaps = 38/242 (15%) Query: 29 KKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKL-----NHKNIVKLFA--IEEETTTRH 81 K L A K+ +I+ E E K + H N+ + + + Sbjct: 66 KDKQRLVA-KIERSIAEG----HLFAELEAYKHIYKTAGKHPNLANVHGMAVVPYGNRYY 120 Query: 82 KVLIMEFCPC-------GSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHR 134 L+M+ SL ++ + ++ NHL + GIVH Sbjct: 121 YALLMDEVDGWRCSDTLRSLADSWKQGKINSEAYWGTIKFIAHRLLDVTNHLAKAGIVHN 180 Query: 135 DIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDH 194 DIKPGN++ V D G EQ TE + P++ + Sbjct: 181 DIKPGNVVFDRASGEPVVI---DLGL--HSRSGEQPKGF--TESFKAPELGVGNLGA--- 230 Query: 195 QKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAEN 254 D++ + G F + N+ + + IT +P+ + + Sbjct: 231 ----SEKSDVF---LVVSTLLHGIEGFEKDPEIKPNQGL--RFITSEPAHVMDENGYPIH 281 Query: 255 GP 256 P Sbjct: 282 RP 283 >2JII-A nrPDB Length = 352 Score = 59.6 bits (143), Expect = 5e-09, Method: Composition-based stats. Identities = 43/219 (19%), Positives = 77/219 (35%), Gaps = 12/219 (5%) Query: 71 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 130 F + ++ +++ L++ SL + L+ S + L E L V ++ + L EN Sbjct: 125 FGVHQD---KYRFLVLPSL-GRSLQSALD-VSPKHVLSERSVLQVACRLLDALEFLHENE 179 Query: 131 IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVL 190 VH ++ NI + + QS L +G A + V+ P + + Sbjct: 180 YVHGNVTAENIF--VDPEDQSQVTLAGYGFAFRYCPSGKHVAYVEGS--RSPHEGDLEFI 235 Query: 191 RKDHQKKYGAT--VDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISG 248 D K G + DL S+G G LP+ + + KP + Sbjct: 236 SMDLHKGCGPSRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFVGP 295 Query: 249 VQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEA 287 + V +L+ + +L N LEA Sbjct: 296 CGHWIRPSETLQKYLKVVMALTYEEKPPYA-MLRNNLEA 333 >4OAU-C nrPDB Length = 699 Score = 57.7 bits (138), Expect = 2e-08, Method: Composition-based stats. Identities = 31/173 (17%), Positives = 63/173 (36%), Gaps = 22/173 (12%) Query: 1 MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLK 60 ++ + + ++D + ++ G ++K A+K F RE L+ Sbjct: 341 LKFFIDEKYKIADT----SEGGIYLGFYEK--QEVAVKTF-----CEGSPRAQREVSCLQ 389 Query: 61 KLN-HKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESE--FLIVLR 117 + ++V + E+ H + + C +L L+ E + VL Sbjct: 390 SSRENSHLVTFYG--SESHRGHLFVCVTLCE-QTLEACLDVHRGEDVENEEDEFARNVLS 446 Query: 118 DVVGGMNHLR-ENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQ 169 + + L G H+D++P NI+ D + L DF + + D Q Sbjct: 447 SIFKAVQELHLSCGYTHQDLQPQNILI----DSKKAAHLADFDKSIKWAGDPQ 495 >6BHC-A nrPDB Length = 438 Score = 54.2 bits (129), Expect = 2e-07, Method: Composition-based stats. Identities = 41/277 (14%), Positives = 86/277 (31%), Gaps = 38/277 (13%) Query: 35 FAIKVFNNISFLRP--------VDVQMREFEVLKKLNH-----KNIVKLFAIEEETTTR- 80 +A+K+ + + F + + H N +L E+ + + Sbjct: 86 YAVKICKSKAKESQQYYHSLAVRQSLAVHFNIQQDCGHFLAEVPN--RLLPWEDPSKKQR 143 Query: 81 -HKVLIMEFCPCGSLYTVLE----EPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRD 135 H V+I PC ++ + + + L E + ++L + G+ HL+ + H D Sbjct: 144 SHVVVITREVPCLTVADFVRDSLAQHGKSPDLYERQVCLLLLQLCSGLEHLKPYHVTHCD 203 Query: 136 IKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGT--------EEYLHPDMY-- 185 ++ N++ V + G + FG A L + + P++ Sbjct: 204 LRLENLLLVHYQPGGTAQ---GFGPAEPTPTSSYPTRLIVSNFSQAKQKSHLVDPEILRD 260 Query: 186 -ERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSG 244 R +Y D + G+ Y PF E P + + + Sbjct: 261 QSRLAPEIITATQY-KKCDEFQTGILIYEMLHLPNPFD--ENPELKEREYTRADLPRIPF 317 Query: 245 AISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVL 281 + + P L + +L +L Sbjct: 318 RSPYSRGLQQLASCLLNPNPSERILISDAKGILQCLL 354 >6EWX-A nrPDB Length = 484 Score = 53.1 bits (126), Expect = 4e-07, Method: Composition-based stats. Identities = 42/255 (16%), Positives = 78/255 (30%), Gaps = 77/255 (30%) Query: 80 RHKVLIMEFCPCGSLYTVLEEPSNAYGLP----ESEFLIVLRDVVGGMNHLRENGIVHRD 135 V+I P + + + ++ E +L + G+ HL+E+GI+HRD Sbjct: 176 DCVVVITREVPHQTASDFVRDSVASHRAEPEVYERRVCFLLLQLCNGLEHLKEHGIIHRD 235 Query: 136 IKPGNIMRV-------------------------------------IGEDGQSVYKLTDF 158 + N++ V GE +++F Sbjct: 236 LCLENLLLVHCNPQSSPGPSANPSVPTTTSRCPSAAPAATTACQGGPGEKHLPRLIISNF 295 Query: 159 GAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGS 218 A++ + ++ L P++ + RK + + G+ Y Sbjct: 296 LKAKQKPGGTTNLQQKKSQARLAPEIVSASQYRKFDEFQ---------TGILIYELL--H 344 Query: 219 LPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLT 278 P PFE + +E Y+ D+P +LS L Sbjct: 345 QP-NPFEVRAQLRERDYR-----------------------REDLPPLPTLS-LYSPGLQ 379 Query: 279 PVLANILEADQEKCW 293 + +LEAD K Sbjct: 380 QLAHLLLEADPIKRI 394 >5VE6-A nrPDB Length = 492 Score = 50.0 bits (118), Expect = 4e-06, Method: Composition-based stats. Identities = 16/69 (23%), Positives = 32/69 (46%), Gaps = 4/69 (5%) Query: 80 RHKVLIMEFCPCGSLYTVLEEPSNAYGLP----ESEFLIVLRDVVGGMNHLRENGIVHRD 135 V+I P + + + + ++ E +L + G+ HL+E+GI+HRD Sbjct: 174 DCVVVITREVPHQTASDFVRDSAASHQAEPEAYERRVCFLLLQLCNGLEHLKEHGIIHRD 233 Query: 136 IKPGNIMRV 144 + N++ V Sbjct: 234 LCLENLLLV 242 >4AZW-A nrPDB Length = 471 Score = 49.6 bits (117), Expect = 5e-06, Method: Composition-based stats. Identities = 23/126 (18%), Positives = 44/126 (34%), Gaps = 19/126 (15%) Query: 39 VFNNISFLRPVDVQMREFEVLKK----LNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSL 94 + R E + L + + ++ + L+ME P L Sbjct: 275 ILTAEESQRNKHELHNEIKFLTQPPAGFDAPAVLA-----HGENAQSGWLVMEKLPGRLL 329 Query: 95 YTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYK 154 +L E + +L ++ + L + G H D++P N+M D + + Sbjct: 330 SDMLAAGE------EIDREKILGSLLRSLAALEKKGFWHDDVRPWNVMV----DARQHAR 379 Query: 155 LTDFGA 160 L DFG+ Sbjct: 380 LIDFGS 385 >4CYJ-A nrPDB Length = 438 Score = 49.2 bits (116), Expect = 6e-06, Method: Composition-based stats. Identities = 24/155 (15%), Positives = 52/155 (33%), Gaps = 22/155 (14%) Query: 23 VFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLK---KLNHKNIVKLFAIEEETTT 79 V++ ++ + G +A++ + V+K K+ + +IV + + Sbjct: 71 VYKAQNSRNGRHYALRRLEGYRLTNEKAI----LNVMKDWKKIKNASIVTIHEVFTTREF 126 Query: 80 RHKVLIMEFCPCGSLYTVLEEP----------SNAYGLPESEFLIVLRDVVGGMNHLREN 129 LI + L L+E +PE+ + + + + N Sbjct: 127 GDSSLIFAY-DFHPLSKTLQEHHFQPIHGNRYRPPPAVPENTIWGYICQIANALKTIHSN 185 Query: 130 GIVHRDIKPGN-IMRVIGEDGQSVYKLTD---FGA 160 + R ++P I+ I S + D FG Sbjct: 186 RLAARCLEPSKIILTDINRIRLSACAILDVVQFGM 220 >4AZV-A nrPDB Length = 569 Score = 48.4 bits (114), Expect = 1e-05, Method: Composition-based stats. Identities = 23/126 (18%), Positives = 44/126 (34%), Gaps = 19/126 (15%) Query: 39 VFNNISFLRPVDVQMREFEVLKK----LNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSL 94 + R E + L + + ++ + L+ME P L Sbjct: 275 ILTAEESQRNKYELHNEIKFLTQPPAGFDAPAVLA-----HGENAQSGWLVMEKLPGRLL 329 Query: 95 YTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYK 154 +L E + +L ++ + L + G H D++P N+M D + + Sbjct: 330 SDMLAAGE------EIDREKILGSLLRSLAALEKQGFWHDDVRPWNVMV----DARQHAR 379 Query: 155 LTDFGA 160 L DFG+ Sbjct: 380 LIDFGS 385 >6R5K-O nrPDB Length = 689 Score = 48.4 bits (114), Expect = 1e-05, Method: Composition-based stats. Identities = 19/111 (17%), Positives = 41/111 (36%), Gaps = 3/111 (2%) Query: 24 FRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIEEETTTRHK- 82 F+ G + +K NI + + +++ K+N N++K I + T Sbjct: 311 FKVFSNYDGKAYVLKRLPNIDKSMNPNKISKIYQIWSKINCTNLIKFRDIFQTTKFGDLS 370 Query: 83 -VLIMEFCPCG-SLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGI 131 L+ ++ P SLY + + + I L + +N + + Sbjct: 371 ICLVFDYYPNSLSLYDYHFVNFPKFPITNNYLWIYLVQLTNVINSIHSQNL 421 >4XR7-L nrPDB Length = 465 Score = 47.3 bits (111), Expect = 2e-05, Method: Composition-based stats. Identities = 19/111 (17%), Positives = 41/111 (36%), Gaps = 3/111 (2%) Query: 24 FRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIEEETTTRHK- 82 F+ G + +K NI + + +++ K+N N++K I + T Sbjct: 87 FKVFSNYDGKAYVLKRLPNIDKSMNPNKISKIYQIWSKINCTNLIKFRDIFQTTKFGDLS 146 Query: 83 -VLIMEFCPCG-SLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGI 131 L+ ++ P SLY + + + I L + +N + + Sbjct: 147 ICLVFDYYPNSLSLYDYHFVNFPKFPITNNYLWIYLVQLTNVINSIHSQNL 197 >4BWP-A nrPDB Length = 448 Score = 46.5 bits (109), Expect = 4e-05, Method: Composition-based stats. Identities = 27/164 (16%), Positives = 55/164 (33%), Gaps = 32/164 (19%) Query: 24 FRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIEEET--TTRH 81 +R H TG + ++ + + + E+ KKL H N+V+L + Sbjct: 67 YRATHNTTGYKYCLRRIHGFRLQSTKCMTL--VEMWKKLQHTNVVQLREVFTTKAFGDNS 124 Query: 82 KVLIMEFCPC-----------------------GSLYTV-----LEEPSNAYGLPESEFL 113 VL+ ++ P G ++ SN LPE+ Sbjct: 125 LVLVYDYHPGSQTLLAKYFTPAPETNGYTDPFQGEARPFSHKSNMQRTSNGPLLPEATIW 184 Query: 114 IVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTD 157 ++ + G+ + G+ + + P I+ S ++D Sbjct: 185 SIIMQLTAGLKAIHHAGLACKVLDPTKIIVTGKRVRFSSCCISD 228 >4WWA-A nrPDB Length = 261 Score = 45.8 bits (107), Expect = 7e-05, Method: Composition-based stats. Identities = 37/172 (21%), Positives = 57/172 (33%), Gaps = 34/172 (19%) Query: 15 LGQGATANV-------FRGRHKKTGDLFAIKVFNNISFLRPVDVQ-------MREFEVLK 60 + QGA A V + R K + + IK + P Q + E +L Sbjct: 22 ISQGAEAIVFTTTTHPYLPRAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNESRLLA 81 Query: 61 KLNHKNIV------KLFAIEEETTTRHKVLIMEFCPCG----SLYTVL--EEPSNAYGLP 108 KL ++ +L A + + E P G +L L + L Sbjct: 82 KL---YLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLV 138 Query: 109 ESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGA 160 + V R + G+ L N H D+ NI+ V + L DFG Sbjct: 139 ATTLRKVGRQI--GL--LHWNDYCHGDLTSSNIVLVRDG-ARWTPHLIDFGL 185 >3BYV-A nrPDB Length = 377 Score = 45.4 bits (106), Expect = 1e-04, Method: Composition-based stats. Identities = 27/127 (21%), Positives = 47/127 (37%), Gaps = 10/127 (7%) Query: 97 VLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLT 156 +L S L L + V+ + L G+VH ++P +I+ D + LT Sbjct: 193 LLSHSSTHKSLVHHARLQLTLQVIRLLASLHHYGLVHTYLRPVDIVL----DQRGGVFLT 248 Query: 157 DFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQKK---YGATVDLWSIGVTFYH 213 F L D V + + P++ R H+ + + D W++G+ Y Sbjct: 249 GF---EHLVRDGARVVSSVSRGFEPPELEARRATISYHRDRRTLMTFSFDAWALGLVIYW 305 Query: 214 AATGSLP 220 LP Sbjct: 306 IWCADLP 312 >3ENH-A nrPDB Length = 540 Score = 41.9 bits (97), Expect = 0.001, Method: Composition-based stats. Identities = 28/161 (17%), Positives = 57/161 (35%), Gaps = 24/161 (14%) Query: 14 ILGQGATANVFRGRHKKTGDLFAIK-VFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFA 72 ++G+GA A++ R IK +D +R+ ++ + +VK F Sbjct: 343 LIGKGAEADIK--RDSYLDFDVIIKERVKKGYRDERLDENIRKSRTAREARYLALVKDFG 400 Query: 73 I----EEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE 128 I + +K ++M + V+E+ L + + + L + Sbjct: 401 IPAPYIFDVDLDNKRIMMSYINGKLAKDVIEDN-----------LDIAYKIGEIVGKLHK 449 Query: 129 NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQ 169 N ++H D+ N + + DFG + DE Sbjct: 450 NDVIHNDLTTSNFIFDKD------LYIIDFGLGKISNLDED 484 >6M7Z-A nrPDB Length = 319 Score = 41.9 bits (97), Expect = 0.001, Method: Composition-based stats. Identities = 21/131 (16%), Positives = 45/131 (34%), Gaps = 13/131 (9%) Query: 81 HKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGN 140 I G + +LE + ++ ++V + L G++HR I+ Sbjct: 120 FLTYIFHPLSKGLVGDMLETGR-----SHPDVQVLAANMVAALKSLHNLGLLHRSIE--- 171 Query: 141 IMRVIGEDGQSVYKLTDFGAARELEDDEQF-VSLYGTEEYLHPDMYERAVLR-KDHQKKY 198 + L A + + + V +G E P++ + Q ++ Sbjct: 172 -LNSFSVLPDGTVVLGGLDTAAPIGTETRLWVGFFGQET--APEIDRNFLADLALTQGRH 228 Query: 199 GATVDLWSIGV 209 D++S+GV Sbjct: 229 TVKSDVYSLGV 239 >3DZO-A nrPDB Length = 413 Score = 41.5 bits (96), Expect = 0.001, Method: Composition-based stats. Identities = 28/126 (22%), Positives = 46/126 (36%), Gaps = 9/126 (7%) Query: 97 VLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLT 156 +L S L L + V+ + L G+VH ++P +I+ D + LT Sbjct: 198 LLSHSSTHKSLVHHARLQLTLQVIRLLASLHHYGLVHTYLRPVDIVL----DQRGGVFLT 253 Query: 157 DFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLR--KDHQKKYGATVDLWSIGVTFYHA 214 G + D VS G + P+ +L + H D W++G+ Y Sbjct: 254 --GFEHLVRDGASAVSPIG-RGFAPPETTAERMLPFGQHHPTLMTFAFDTWTLGLAIYWI 310 Query: 215 ATGSLP 220 LP Sbjct: 311 WCADLP 316 >6G38-A nrPDB Length = 357 Score = 41.1 bits (95), Expect = 0.002, Method: Composition-based stats. Identities = 29/189 (15%), Positives = 53/189 (28%), Gaps = 53/189 (28%) Query: 13 DILGQGATANVFRGRHKKTGDLFAIKVF-------NNISFLRPVDVQMREFEVLKKL--- 62 + +G+G VF+ T AIK+ N S + + + E + K+L Sbjct: 47 EKIGEGVFGEVFQTIADHT--PVAIKIIAIEGPDLVNGSHQKTFEEILPEIIISKELSLL 104 Query: 63 --------------NHKNIVK------LFAIEEETT--------------TRHKVLIMEF 88 N + V+ L + +++EF Sbjct: 105 SGEVCNRTEGFIGLNSVHCVQGSYPPLLLKAWDHYNSTKGSANDRPDFFKDDQLFIVLEF 164 Query: 89 CPCG-SLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR-ENGIVHRDIKPGNIMRVIG 146 G L E + +L + + HRD+ GN++ Sbjct: 165 EFGGIDL-----EQMRTKLSSLATAKSILHQLTASLAVAEASLRFEHRDLHWGNVLLKKT 219 Query: 147 EDGQSVYKL 155 + Y L Sbjct: 220 SLKKLHYTL 228 >2W1Z-A nrPDB Length = 368 Score = 41.1 bits (95), Expect = 0.002, Method: Composition-based stats. Identities = 35/168 (20%), Positives = 59/168 (35%), Gaps = 14/168 (8%) Query: 97 VLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLT 156 +L S L L + ++ L+ G+VH D + NI+ D + LT Sbjct: 178 LLSHSSTHKSLVHHARLQLTLQLIRLAASLQHYGLVHADFQVRNILL----DQRGGVFLT 233 Query: 157 DFGAARELEDDEQFVSLYGTEEYLHPDMYERAVL--RKDHQKKYGATVDLWSIGVTFYHA 214 G + D VS G + P+ +L R+ H D W++G+ Y Sbjct: 234 --GFEHLVRDGASAVSPIG-RGFAPPETTAERMLPYRQHHPTLMTFPFDTWTLGLAIYWI 290 Query: 215 ATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGPIDWSGD 262 LP + E +Y+ P V+ G + +S + Sbjct: 291 WCADLP-NTEDAELGGIEWIYRRCKNIPQP----VRALLEGFLRYSKE 333 >4CZY-B nrPDB Length = 429 Score = 39.6 bits (91), Expect = 0.005, Method: Composition-based stats. Identities = 21/150 (14%), Positives = 45/150 (30%), Gaps = 23/150 (15%) Query: 24 FRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVL------KKLNHKNIVKLFAIEEET 77 ++ ++ K G FA++ E +L KK+ + NIV + Sbjct: 61 YKAQNNKNGRHFALRRIEGYRLT-------NEKAILNVTKEWKKIINANIVTVHEAFTTE 113 Query: 78 TTRHKVLIMEFCPC---GSLYTVL-------EEPSNAYGLPESEFLIVLRDVVGGMNHLR 127 LI + +LY N +PE+ + + + + Sbjct: 114 FFGDSSLIFVYDFHPLSETLYDHHFPPNNSHNRLRNTNKIPENLLWSYVCQIANALLAIH 173 Query: 128 ENGIVHRDIKPGNIMRVIGEDGQSVYKLTD 157 + R ++ I+ + + D Sbjct: 174 NAKLAARCLELSKIIWENNRIRLAACSILD 203 >1TQM-A nrPDB Length = 282 Score = 39.2 bits (90), Expect = 0.006, Method: Composition-based stats. Identities = 30/174 (17%), Positives = 56/174 (32%), Gaps = 37/174 (21%) Query: 11 LSDILGQGATANVFRGRHKKTGDLFAI---------KVFNNISFLRP-------VDVQMR 54 + ++G+G + VF +K G+ K + Sbjct: 94 IGKLMGEGKESAVFNCYSEKFGECVVKFHKVGHTSFKKVKEKRDYGDLHFSVLAIRSARN 153 Query: 55 EFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLI 114 EF L+KL A+ + ++ME LY V E + Sbjct: 154 EFRALQKLQG------LAVPKVYAWEGNAVLMELIDAKELYRVRVENPDE---------- 197 Query: 115 VLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDE 168 VL ++ + GIVH D+ N++ + + DF + E+ ++ Sbjct: 198 VLDMILEEVAKFYHRGIVHGDLSQYNVLV-----SEEGIWIIDFPQSVEVGEEG 246 >6FAI-l nrPDB Length = 425 Score = 35.7 bits (81), Expect = 0.069, Method: Composition-based stats. Identities = 27/177 (15%), Positives = 64/177 (36%), Gaps = 38/177 (21%) Query: 6 NHLWLLSDILGQGATANVFRGRHKKTGDLFAIKV-----------FNNISFLRPVD---- 50 + ++ + + +G G +++++ K +K+ NN +L+ + Sbjct: 92 DTVYSVGNTIGVGKESDIYKVSDKNGNPRV-MKIHRLGRTSFHSVRNNRDYLKKSNQGAN 150 Query: 51 -------VQMREFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSN 103 +E++ + L K F + E +++ME + L + N Sbjct: 151 WMHLSRLAANKEYQFMSMLYSKG----FKVPEPFDNSRHIVVMELIEGYPMR-RLRKHKN 205 Query: 104 AYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVY--KLTDF 158 L S+ + + D+ +G++H D NIM + ++ + DF Sbjct: 206 IPKL-YSDLMCFIVDLA-------NSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDF 254 >5YK0-A nrPDB Length = 452 Score = 35.4 bits (80), Expect = 0.11, Method: Composition-based stats. Identities = 28/188 (14%), Positives = 53/188 (28%), Gaps = 55/188 (29%) Query: 21 ANVFRGRHKKTGDLFAIKVF---NNISFLRPVDVQMREFEVLKKL--------------- 62 V + G A+K+ + + + R VLK+L Sbjct: 146 GQVHKAIW-SDGREVAVKIQYPGADEALRADLKTMQRMVGVLKQLSPGADVQGVVDELVE 204 Query: 63 -----------------------NHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLE 99 +H F + + KV+I E+ + ++ Sbjct: 205 RTEMELDYRLEAANQRAFAKAYHDHPR----FQVPHVVASAPKVVIQEWIEGVPMAEIIR 260 Query: 100 EPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFG 159 + +L ++ + R G++H D PGN M + + DFG Sbjct: 261 HGTTEQR---DLIGTLLAELT--FDAPRRLGLMHGDAHPGNFMLLPDGRMG----IIDFG 311 Query: 160 AARELEDD 167 A + Sbjct: 312 AVAPMPGG 319 >5JY7-I nrPDB Length = 441 Score = 32.7 bits (73), Expect = 0.57, Method: Composition-based stats. Identities = 16/76 (21%), Positives = 29/76 (38%), Gaps = 9/76 (11%) Query: 23 VFRGRHKKTGDLF---AI-KVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIEEETT 78 VF T +F AI K+F I+ D+++ VL + + ++ +L E Sbjct: 126 VFGAEQSNTSVVFGEDAIFKLFRRITPGVHPDIELN--RVLARAGNPHVARLLGSFETEW 183 Query: 79 TRHKV---LIMEFCPC 91 ++ EF Sbjct: 184 EGEPYALGMVTEFAAN 199 >2PZ1-A nrPDB Length = 466 Score = 32.7 bits (73), Expect = 0.66, Method: Composition-based stats. Identities = 13/76 (17%), Positives = 25/76 (32%), Gaps = 8/76 (10%) Query: 63 NHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESE-FLIVLRDVVG 121 NH N +E T+ + F C L +++ + + L + + Sbjct: 215 NHPN----ACVELSRLTKLSKYVYFFEACRLLQKMIDISLDGFLLTPVQKICKYPLQLAE 270 Query: 122 GMNHLRENGIVHRDIK 137 + + HRD K Sbjct: 271 LLKYTHPQ---HRDFK 283 >6J2C-O nrPDB Length = 393 Score = 32.3 bits (72), Expect = 0.70, Method: Composition-based stats. Identities = 22/88 (25%), Positives = 45/88 (51%), Gaps = 7/88 (7%) Query: 580 EQIHKFDKQKLYYHATKAMTHFTDEC------VKKYEAFLNKSEEWIRKMLHLRKQLLSL 633 EQ KF ++KL++ ++++T F D+ ++ Y+ F++K + I + L + K LL+ Sbjct: 27 EQFEKFYEEKLWFQLSESLTKFFDDAKSTPLRLRLYDNFVSKFYDKINQ-LSVVKYLLAS 85 Query: 634 TNQCFDIEEEVSKYQEYTNELQETLPQK 661 D +E + + + QE +K Sbjct: 86 LKDSKDFDESLKYLDDLKAQFQELDSKK 113 >5LVV-A nrPDB Length = 749 Score = 31.9 bits (71), Expect = 0.92, Method: Composition-based stats. Identities = 23/89 (25%), Positives = 44/89 (49%), Gaps = 13/89 (14%) Query: 474 NIEKTVKVYEKLMKINLEAAELGEISDIHTKLLRLSSSQGTIETSLQDIDS--RLSPGGS 531 NIE+ V++Y K +++ E + H+ L + QG ++ +L R+SP + Sbjct: 45 NIEEAVRLYRKALEV------FPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISP--T 96 Query: 532 LADAWAHQEGTHPKDRNVEKLQVLLNCMT 560 ADA+++ T + ++ +Q L C T Sbjct: 97 FADAYSNMGNTL---KEMQDVQGALQCYT 122 >4L0O-H nrPDB Length = 388 Score = 31.9 bits (71), Expect = 0.95, Method: Composition-based stats. Identities = 13/73 (17%), Positives = 25/73 (34%), Gaps = 4/73 (5%) Query: 136 IKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLY----GTEEYLHPDMYERAVLR 191 IKP + + K+TD + D +++ T Y +P + ++ Sbjct: 131 IKPNTKALYLETPSNPLLKITDLAQCASVAKDHGLLTIVDNTFATPYYQNPLLLGADIVA 190 Query: 192 KDHQKKYGATVDL 204 K G D+ Sbjct: 191 HSGTKYLGGHSDV 203 >6G18-v nrPDB Length = 552 Score = 31.9 bits (71), Expect = 0.98, Method: Composition-based stats. Identities = 22/107 (20%), Positives = 37/107 (34%), Gaps = 17/107 (15%) Query: 52 QMREFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESE 111 M+EF +K L + F + + ++ME L + A E+ Sbjct: 158 AMKEFAYMKALYE----RKFPVPKPIDYNRHAVVMELINGYPLCQIHHVEDPASVYDEAM 213 Query: 112 FLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDF 158 LIV L +G++H D N++ D + DF Sbjct: 214 ELIVK---------LANHGLIHGDFNEFNLIL----DESDHITMIDF 247 >6FDN-A nrPDB Length = 320 Score = 31.9 bits (71), Expect = 1.1, Method: Composition-based stats. Identities = 22/107 (20%), Positives = 37/107 (34%), Gaps = 17/107 (15%) Query: 52 QMREFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESE 111 M+EF +K L + F + + ++ME L + A E+ Sbjct: 158 AMKEFAYMKALYE----RKFPVPKPIDYNRHAVVMELINGYPLCQIHHVEDPASVYDEAM 213 Query: 112 FLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDF 158 LIV L +G++H D N++ D + DF Sbjct: 214 ELIVK---------LANHGLIHGDFNEFNLIL----DESDHITMIDF 247 >1UB7-A nrPDB Length = 322 Score = 31.5 bits (70), Expect = 1.4, Method: Composition-based stats. Identities = 29/118 (24%), Positives = 53/118 (44%), Gaps = 27/118 (22%) Query: 609 YEAFLNKSEEWIRKMLHLRKQLLSLTNQCFDIEEEVSKYQEYTNELQ----ETLPQKMFT 664 +EA+L+ S+EWI ++ E V+ EYT++L E L ++ Sbjct: 21 FEAYLDTSDEWIVTRTGIK-------------ERRVAAEDEYTSDLAFKAVEDLLRRHPG 67 Query: 665 ASSGIK----HTMTP--IYPSSNTLVEMTLGMKKLKEEM----EGVVKELAENNHILE 712 A G+ T TP ++P + LV+ G+K ++ G + LA+ + ++E Sbjct: 68 ALEGVDAVIVATNTPDALFPDTAALVQARFGLKAFAYDLLAGCPGWIYALAQAHALVE 125 >6DFL-A nrPDB Length = 259 Score = 30.0 bits (66), Expect = 3.7, Method: Composition-based stats. Identities = 23/129 (17%), Positives = 49/129 (37%), Gaps = 13/129 (10%) Query: 13 DILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNI----- 67 ++ G+G + RG G++ K N ++ PV +E++ +++L+ + Sbjct: 42 EVDGRGYFVKIHRGI--GWGEI--AK--NLLTAKLPVLGARQEWQAIRRLHEAGVATMTA 95 Query: 68 VKLFAIEEETTTRHKVLIME-FCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 126 V + +H ++ E P L V + P ++ V + + Sbjct: 96 VAYGERGSDPARQHSFIVTEELAPTVDL-EVFSQDWRERPPPPRLKRALVEAVARMVGDM 154 Query: 127 RENGIVHRD 135 G+ HRD Sbjct: 155 HRAGVNHRD 163 >3LQ3-A nrPDB Length = 401 Score = 30.0 bits (66), Expect = 3.8, Method: Composition-based stats. Identities = 24/99 (24%), Positives = 40/99 (40%), Gaps = 15/99 (15%) Query: 69 KLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSN--AYGLPESEFLIV--LRDVVGGMN 124 + +E T L G++ L++ + GLPE L + L+D +G + Sbjct: 179 QFHGMEMPFTKEPHWL------FGTMERYLKQIQDLPPTGLPEMNLLEMYSLKDEMGNLR 232 Query: 125 HLRENG-----IVHRDIKPGNIMRVIGEDGQSVYKLTDF 158 L E+ H DI+ GNI+ + + L DF Sbjct: 233 KLLESTPSPVVFCHNDIQEGNILLLSEPENADSLMLVDF 271 >4ZLK-A nrPDB Length = 839 Score = 30.0 bits (66), Expect = 3.9, Method: Composition-based stats. Identities = 9/62 (14%), Positives = 26/62 (41%) Query: 72 AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGI 131 + ++ KVL++ L L+ + + ++V + + +++L E + Sbjct: 74 ELLKDYKPGDKVLLLHLEEGKDLEYRLDPKTGELPHLRNPDILVGENDLTALSYLHEPAV 133 Query: 132 VH 133 +H Sbjct: 134 LH 135 >1W3B-A nrPDB Length = 388 Score = 29.6 bits (65), Expect = 4.6, Method: Composition-based stats. Identities = 19/71 (26%), Positives = 36/71 (50%), Gaps = 10/71 (14%) Query: 474 NIEKTVKVYEKLMKINLEAAELGEISDIHTKLLRLSSSQGTIETSLQDIDS--RLSPGGS 531 NIE+ V++Y K +++ E + H+ L + QG ++ +L R+SP + Sbjct: 320 NIEEAVRLYRKALEV------FPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISP--T 371 Query: 532 LADAWAHQEGT 542 ADA+++ T Sbjct: 372 FADAYSNMGNT 382 >4BVU-A nrPDB Length = 211 Score = 29.6 bits (65), Expect = 4.7, Method: Composition-based stats. Identities = 28/156 (17%), Positives = 57/156 (36%), Gaps = 32/156 (20%) Query: 10 LLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVK 69 +L ++GQG+TA +F + + K ++ I Q E + + Sbjct: 43 ILGKLIGQGSTAEIFEDVNDSSALY---KKYDLIGN------QYNEILEMAWQESE---- 89 Query: 70 LFAIEEETTTRHKVLIMEFCPCGSLY-TVLEEPSNAYG------LPESEFLIVLRDVVGG 122 LF +++++ G +Y +L P +P++ + L+ + Sbjct: 90 LFNAFY---GDEASVVIQY--GGDVYLRMLRVPGTPLSDIDTADIPDNIESLYLQLICK- 143 Query: 123 MNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDF 158 L E I+H D+ GN++ + DF Sbjct: 144 ---LNELSIIHYDLNTGNMLYDKESESLFPI---DF 173 >1ZP9-A nrPDB Length = 258 Score = 29.6 bits (65), Expect = 4.9, Method: Composition-based stats. Identities = 45/221 (20%), Positives = 71/221 (32%), Gaps = 52/221 (23%) Query: 11 LSDILGQGATANVFRGRHKKTGDLF--AIKVFN-------------------NISFLRPV 49 + ++ G ANVF G A+K++ ++ + P Sbjct: 51 MGGVISTGKEANVFYADGVFDGKPVAMAVKIYRIETSEFDKMDEYLYGDERFDMRRISPK 110 Query: 50 DVQM----REFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSL-YTVLEEPSNA 104 + +EF L++ + ++ + T VL+MEF L L E Sbjct: 111 EKVFIWTEKEFRNLERAKEAGV----SVPQPYTYMKNVLLMEFIGEDELPAPTLVELGRE 166 Query: 105 YGLPESEFLIVLRDVVGGMNHL-RENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARE 163 L E + + DVV + L +E +VH D+ NIM + D G A Sbjct: 167 --LKELDVEGIFNDVVENVKRLYQEAELVHADLSEYNIMYIDK------VYFIDMGQAVT 218 Query: 164 LEDDEQFVSLYGTEEYLHPDMYERAVLRKDH-QKKYGATVD 203 L + ER V KYG D Sbjct: 219 L------------RHPMAESYLERDVRNIIRFFSKYGVKAD 247 >4QX0-A nrPDB Length = 587 Score = 29.6 bits (65), Expect = 5.3, Method: Composition-based stats. Identities = 19/65 (29%), Positives = 31/65 (47%), Gaps = 10/65 (15%) Query: 576 AYNEEQIHKFDKQKLYYHATKAMTHFTDECVKKYEAFLNK-----SEEWIRKMLHLRKQL 630 Y +E I +F K++L K +TD CVK Y L+K E W+ + R+ Sbjct: 162 GYEKEDIAEFYKRQL-----KLTQEYTDHCVKWYNVGLDKLRGSSYESWVNFNRYRREMT 216 Query: 631 LSLTN 635 L++ + Sbjct: 217 LTVLD 221 >6BQ8-A nrPDB Length = 152 Score = 28.8 bits (63), Expect = 9.1, Method: Composition-based stats. Identities = 22/128 (17%), Positives = 41/128 (32%), Gaps = 13/128 (10%) Query: 52 QMREFEVLKKLNHKNIVKLFAIEE-ETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPES 110 +R +LK L + K+ E E + +I E + + + + E Sbjct: 14 FLRSVSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEG 73 Query: 111 EFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQF 170 L + + E ++ D++ NI+ + A + D E F Sbjct: 74 HDQPQLIKTLQKGEYFGEKALISDDVRSANIIAEEND------------VACLVIDRETF 121 Query: 171 VSLYGTEE 178 GT E Sbjct: 122 NQTVGTFE 129 >4FO0-A nrPDB Length = 593 Score = 28.8 bits (63), Expect = 9.5, Method: Composition-based stats. Identities = 22/86 (25%), Positives = 40/86 (46%), Gaps = 4/86 (4%) Query: 506 LRLSSSQGTIETSLQDIDSRL--SPGGSL-ADAWAHQEGTHPKDRNVEKLQVLLNCMTEI 562 LR+ + T+ S+ + +R G L D+W +EG + + N E+ Q L + + Sbjct: 27 LRIGRATDTLPASIPHVIARRHKQQGQPLYKDSWLLREGLNKPESN-EQRQNGLKMVDQA 85 Query: 563 YYQFKKDKAERRLAYNEEQIHKFDKQ 588 + K RR+ + EQ ++KQ Sbjct: 86 IWSKKMSNGTRRIPVSPEQARSYNKQ 111 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.314 0.141 0.422 Lambda K H 0.267 0.0432 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 30,584,118 Number of Sequences: 36641 Number of extensions: 1326651 Number of successful extensions: 7942 Number of sequences better than 10.0: 516 Number of HSP's better than 10.0 without gapping: 731 Number of HSP's successfully gapped in prelim test: 247 Number of HSP's that attempted gapping in prelim test: 4024 Number of HSP's gapped (non-prelim): 1109 length of query: 729 length of database: 10,336,785 effective HSP length: 104 effective length of query: 625 effective length of database: 6,526,121 effective search space: 4078825625 effective search space used: 4078825625 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.4 bits) S2: 63 (28.8 bits)