BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q9UGM6 (360 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 5EKD-A nrPDB 703 0.0 3N9I-A nrPDB 281 2e-76 6DFU-A nrPDB 274 5e-74 5V0I-A nrPDB 270 1e-72 5DK4-A nrPDB 267 6e-72 3SZ3-A nrPDB 264 4e-71 3PRH-A nrPDB 250 6e-67 3U1V-A nrPDB 223 8e-59 2EL7-A nrPDB 211 4e-55 2YY5-A nrPDB 196 2e-50 2G36-A nrPDB 192 2e-49 3TZL-A nrPDB 170 8e-43 6MTK-A nrPDB 168 3e-42 6NCR-A nrPDB 140 7e-34 5TEW-A nrPDB 137 5e-33 1YID-B nrPDB 125 3e-29 3A04-A nrPDB 58 8e-09 3JXE-A nrPDB 55 4e-08 3P0I-A nrPDB 50 1e-06 2CYB-A nrPDB 50 2e-06 2CYC-A nrPDB 47 2e-05 5NSF-B nrPDB 44 1e-04 3FOC-A nrPDB 41 0.001 2J5B-A nrPDB 40 0.001 2CYA-A nrPDB 37 0.017 4J75-A nrPDB 35 0.043 3VGJ-A nrPDB 33 0.20 3HV0-A nrPDB 32 0.63 1OUT-A nrPDB 31 0.83 5IJO-H nrPDB 29 3.3 2PK3-A nrPDB 29 3.9 6N2O-A nrPDB 28 4.8 4TN5-A nrPDB 28 4.9 3HBA-A nrPDB 28 6.7 5D0U-A nrPDB 28 7.2 3T97-C nrPDB 27 9.4 >5EKD-A nrPDB Length = 343 Score = 703 bits (1815), Expect = 0.0, Method: Compositional matrix adjust. Identities = 343/343 (100%), Positives = 343/343 (100%) Query: 18 ALHKGSAAAPALQKDSKKRVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSVLYSIVDLH 77 ALHKGSAAAPALQKDSKKRVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSVLYSIVDLH Sbjct: 1 ALHKGSAAAPALQKDSKKRVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSVLYSIVDLH 60 Query: 78 SITVPQDPAVLRQSILDMTAVLLACGINPEKSILFQQSQVSEHTQLSWILSCMVRLPRLQ 137 SITVPQDPAVLRQSILDMTAVLLACGINPEKSILFQQSQVSEHTQLSWILSCMVRLPRLQ Sbjct: 61 SITVPQDPAVLRQSILDMTAVLLACGINPEKSILFQQSQVSEHTQLSWILSCMVRLPRLQ 120 Query: 138 HLHQWKAKTTKQKHDGTVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQDLAQGFN 197 HLHQWKAKTTKQKHDGTVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQDLAQGFN Sbjct: 121 HLHQWKAKTTKQKHDGTVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQDLAQGFN 180 Query: 198 KKYGEFFPVPESILTSMKKVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKAVTD 257 KKYGEFFPVPESILTSMKKVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKAVTD Sbjct: 181 KKYGEFFPVPESILTSMKKVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKAVTD 240 Query: 258 FTSEVTYDPAGRAGVSNIVAVHAAVTGLSVEEVVRRSAGMNTARYKLAVADAVIEKFAPI 317 FTSEVTYDPAGRAGVSNIVAVHAAVTGLSVEEVVRRSAGMNTARYKLAVADAVIEKFAPI Sbjct: 241 FTSEVTYDPAGRAGVSNIVAVHAAVTGLSVEEVVRRSAGMNTARYKLAVADAVIEKFAPI 300 Query: 318 KREIEKLKLDKDHLEKVLQIGSAKAKELAYTVCQEVKKLVGFL 360 KREIEKLKLDKDHLEKVLQIGSAKAKELAYTVCQEVKKLVGFL Sbjct: 301 KREIEKLKLDKDHLEKVLQIGSAKAKELAYTVCQEVKKLVGFL 343 >3N9I-A nrPDB Length = 346 Score = 281 bits (720), Expect = 2e-76, Method: Compositional matrix adjust. Identities = 143/331 (43%), Positives = 211/331 (63%), Gaps = 4/331 (1%) Query: 33 SKKRVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSVLYSIVDLHSITVPQDPAVLRQSI 92 SK VFSG QP+G L +GNY+GA+ WV++QD+YD + Y IVDLH+IT QDPA+LR+ Sbjct: 14 SKPIVFSGAQPSGELTIGNYMGALRQWVQMQDDYDCI-YCIVDLHAITARQDPALLRKRT 72 Query: 93 LDMTAVLLACGINPEKSILFQQSQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHD 152 LD A+ LACGI+P+KS +F QS V EH+QLSW L+C L + Q+K K+ + + Sbjct: 73 LDTLALYLACGIDPKKSTIFVQSHVPEHSQLSWALNCYTYFGELSRMTQFKDKSARYAEN 132 Query: 153 GTVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQDLAQGFNKKYGEFFPVPESIL- 211 GL YPVL AADILLY++ VPVGEDQ QH+EL +D+A FN YG+ F +PE + Sbjct: 133 INAGLFDYPVLMAADILLYQTNQVPVGEDQKQHLELSRDIASRFNNLYGDIFKIPEPFIP 192 Query: 212 TSMKKVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKAVTDFTSE--VTYDPAGR 269 + +V SL+DP+ KMSKSD ++ + + + P+ +V+K ++A+TD + YD + Sbjct: 193 KAGARVMSLQDPTKKMSKSDDNRNNVIELLEDPKSVVKKIKRAMTDSDEPALIRYDVEKK 252 Query: 270 AGVSNIVAVHAAVTGLSVEEVVRRSAGMNTARYKLAVADAVIEKFAPIKREIEKLKLDKD 329 AGVSN++ + + VTG S+ E+ + G K AVADAV + ++ + D+ Sbjct: 253 AGVSNLLDILSGVTGQSIPELEAQFTGQMYGHLKGAVADAVSGMLSELQERYRTYREDEA 312 Query: 330 HLEKVLQIGSAKAKELAYTVCQEVKKLVGFL 360 L+ V++ G+AKA+ A +V + +GF+ Sbjct: 313 LLQDVMREGAAKARARAQVTLAKVYEAIGFV 343 >6DFU-A nrPDB Length = 337 Score = 274 bits (700), Expect = 5e-74, Method: Compositional matrix adjust. Identities = 137/331 (41%), Positives = 210/331 (63%), Gaps = 4/331 (1%) Query: 33 SKKRVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSVLYSIVDLHSITVPQDPAVLRQSI 92 +K VFSG+QP+G L +GNYLGA+ +WV++Q++Y+ + + +VDLH+ITV QDP LR++ Sbjct: 5 AKPIVFSGVQPSGELTIGNYLGALRNWVKMQEDYECI-FCVVDLHAITVRQDPVALRKAT 63 Query: 93 LDMTAVLLACGINPEKSILFQQSQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHD 152 LD+ A+ LACGI+P KS +F QS V EHTQLSW+L+C + + Q+K K+ + + Sbjct: 64 LDVLALYLACGIDPNKSTIFVQSHVPEHTQLSWVLNCYTYFGEMSRMTQFKDKSARYAEN 123 Query: 153 GTVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQDLAQGFNKKYGEFFPVPESIL- 211 VGL YPVL AADILLY++ VPVG+DQ QH+E+ +D+A FN YG F +PE + Sbjct: 124 INVGLFDYPVLMAADILLYQAKSVPVGDDQKQHLEITRDIANRFNALYGNIFTIPEIFIG 183 Query: 212 TSMKKVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKAVTDFTSE--VTYDPAGR 269 + ++ SL+DP KMSKSD ++ V + + P+ + +K ++AVTD V YD + Sbjct: 184 KAGARIMSLQDPEKKMSKSDDNRNNVVTLLEDPKSVAKKIKRAVTDSDEPPVVRYDVQNK 243 Query: 270 AGVSNIVAVHAAVTGLSVEEVVRRSAGMNTARYKLAVADAVIEKFAPIKREIEKLKLDKD 329 AGVSN++ + +AVT + ++ + G K AVAD V A ++ + + D+ Sbjct: 244 AGVSNLLDILSAVTDKPIADLEKEFEGKMYGHLKTAVADEVSTLLASLQERFHQYRNDET 303 Query: 330 HLEKVLQIGSAKAKELAYTVCQEVKKLVGFL 360 L+ +L+ G+ KA+ A +V + VGF+ Sbjct: 304 LLDNILRQGAEKARAKAQETLAKVYEAVGFV 334 >5V0I-A nrPDB Length = 337 Score = 270 bits (689), Expect = 1e-72, Method: Compositional matrix adjust. Identities = 142/331 (42%), Positives = 205/331 (61%), Gaps = 4/331 (1%) Query: 33 SKKRVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSVLYSIVDLHSITVPQDPAVLRQSI 92 +K VFSG QP+G L +GNY+GA+ WV +QD+Y + Y IVD H+ITV QD LR++ Sbjct: 5 TKPIVFSGAQPSGELTIGNYMGALRQWVNMQDDYHCI-YCIVDQHAITVRQDAQKLRKAT 63 Query: 93 LDMTAVLLACGINPEKSILFQQSQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHD 152 LD A+ LACGI+PEKS +F QS V EH QL W L+C L + Q+K K+ + + Sbjct: 64 LDTLALYLACGIDPEKSTIFVQSHVPEHAQLGWALNCYTYFGELSRMTQFKDKSARYAEN 123 Query: 153 GTVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQDLAQGFNKKYGEFFPVPESIL- 211 GL YPVL AADILLY++ VPVGEDQ QH+EL +D+AQ FN YG+ F VPE + Sbjct: 124 INAGLFDYPVLMAADILLYQTNLVPVGEDQKQHLELSRDIAQRFNALYGDIFKVPEPFIP 183 Query: 212 TSMKKVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKAVTDFTSE--VTYDPAGR 269 S +V SL +P+ KMSKSD ++ + + + P+ +V+K ++AVTD V YD + Sbjct: 184 KSGARVMSLLEPTKKMSKSDDNRNNVIGLLEDPKSVVKKIKRAVTDSDEPPVVRYDVQNK 243 Query: 270 AGVSNIVAVHAAVTGLSVEEVVRRSAGMNTARYKLAVADAVIEKFAPIKREIEKLKLDKD 329 AGVSN++ + +AVTG S+ E+ ++ G K VADAV ++ + + D+ Sbjct: 244 AGVSNLLDILSAVTGQSIPELEKQFEGKMYGHLKGEVADAVSGMLTELQERYHRFRNDEA 303 Query: 330 HLEKVLQIGSAKAKELAYTVCQEVKKLVGFL 360 L++V++ G+ KA A + V + +GF+ Sbjct: 304 FLQQVMKDGAEKASAHASRTLKAVYEAIGFV 334 >5DK4-A nrPDB Length = 329 Score = 267 bits (682), Expect = 6e-72, Method: Compositional matrix adjust. Identities = 136/326 (41%), Positives = 211/326 (64%), Gaps = 4/326 (1%) Query: 35 KRVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSVLYSIVDLHSITVPQDPAVLRQSILD 94 K +FSGIQP+G++ +GNY+GA+ +V LQ EY+ + IVD H+ITV QDP LRQ+I Sbjct: 3 KTIFSGIQPSGVITIGNYIGALRQFVELQHEYN-CYFCIVDQHAITVWQDPHELRQNIRR 61 Query: 95 MTAVLLACGINPEKSILFQQSQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHDGT 154 + A+ LA GI+P ++ LF QS+V H Q +W+L C+V + L+ + Q+K K+ K + Sbjct: 62 LAALYLAVGIDPTQATLFIQSEVPAHAQAAWMLQCIVYIGELERMTQFKEKSAG-KEAVS 120 Query: 155 VGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQDLAQGFNKKYGEFFPVPESILTSM 214 GLLTYP L AADILLY + VPVGEDQ QH+EL +DLA+ FNK+YGE F +PE+ + + Sbjct: 121 AGLLTYPPLMAADILLYNTDIVPVGEDQKQHIELTRDLAERFNKRYGELFTIPEARIPKV 180 Query: 215 -KKVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKAVTDFTSEVTYDPAGRAGVS 273 ++ SL DP+ KMSKSDP+ A + + D + I +K + AVTD + YD + G+S Sbjct: 181 GARIMSLVDPTKKMSKSDPNPKAYITLLDDAKTIEKKIKSAVTDSEGTIRYDKEAKPGIS 240 Query: 274 NIVAVHAAVTGLSVEEVVRRSAGMNTARYKLAVADAVIEKFAPIKREIEKLKLDKDHLEK 333 N++ +++ ++G S+EE+ R+ G +K +A VIE PI+ ++ + L++ Sbjct: 241 NLLNIYSTLSGQSIEELERQYEGKGYGVFKADLAQVVIETLRPIQERYHHW-MESEELDR 299 Query: 334 VLQIGSAKAKELAYTVCQEVKKLVGF 359 VL G+ KA +A + +++++ +G Sbjct: 300 VLDEGAEKANRVASEMVRKMEQAMGL 325 >3SZ3-A nrPDB Length = 341 Score = 264 bits (675), Expect = 4e-71, Method: Compositional matrix adjust. Identities = 134/335 (40%), Positives = 209/335 (62%), Gaps = 8/335 (2%) Query: 33 SKKRVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSVLYSIVDLHSITVPQDPAVLRQSI 92 SK V SG+QP+G L +GNYLGA+ W ++QD+YD Y +VDLH+ITV QDP L ++ Sbjct: 5 SKPIVLSGVQPSGELSIGNYLGALRQWQQMQDDYD-CQYCVVDLHAITVRQDPQALHEAT 63 Query: 93 LDMTAVLLACGINPEKSILFQQSQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHD 152 LD A+ LA G++P+KS LF QS V EH QL W+L+C ++ L + Q+K K+ + +D Sbjct: 64 LDALAICLAVGVDPKKSTLFVQSHVPEHAQLGWVLNCYTQMGELSRMTQFKDKSARYAND 123 Query: 153 GTVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQDLAQGFNKKYG---EFFPVPES 209 GL YPVL AADILLY + VPVG DQ QH+EL +D+A FN Y F +PE Sbjct: 124 VNAGLFGYPVLMAADILLYGAHQVPVGSDQKQHLELARDIATRFNNIYSPEQPIFTIPEP 183 Query: 210 ILTSMK-KVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKAVTDFTS--EVTYDP 266 + ++ +V SL+D + KMSKSD ++ + + + P+ I++K KA TD + + YD Sbjct: 184 YIPTVNARVMSLQDATKKMSKSDDNRKNVITLLEDPKSIIKKINKAQTDAETPPRIAYDV 243 Query: 267 AGRAGVSNIVAVHAAVTGLSVEEVVRRSAGMNT-ARYKLAVADAVIEKFAPIKREIEKLK 325 +AG++N++ +++A TG + E+ + AG+ +K V +AV+ P++ E ++++ Sbjct: 244 ENKAGIANLMGLYSAATGKTFAEIEAQYAGVEMYGPFKKDVGEAVVAMLEPVQAEYQRIR 303 Query: 326 LDKDHLEKVLQIGSAKAKELAYTVCQEVKKLVGFL 360 D+++L V++ G+ KA A ++V VGF+ Sbjct: 304 NDREYLNSVMRDGAEKASAKALQTLKKVYAAVGFV 338 >3PRH-A nrPDB Length = 388 Score = 250 bits (639), Expect = 6e-67, Method: Compositional matrix adjust. Identities = 128/327 (39%), Positives = 207/327 (63%), Gaps = 4/327 (1%) Query: 34 KKRVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSVLYSIVDLHSITVPQDPAVLRQSIL 93 K+ +FSGIQP+G + LGNY+GA++ +V LQ +Y+S + IVD H+ITVPQD LR++I Sbjct: 35 KQTIFSGIQPSGSVTLGNYIGAMKQFVELQHDYNSY-FCIVDQHAITVPQDRLELRKNIR 93 Query: 94 DMTAVLLACGINPEKSILFQQSQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHDG 153 ++ A+ LA G++PEK+ LF QS+V H Q W++ C+ + L+ + Q+K K +K Sbjct: 94 NLAALYLAVGLDPEKATLFIQSEVPAHAQAGWMMQCVAYIGELERMTQFKDK-SKGNEAV 152 Query: 154 TVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQDLAQGFNKKYGEFFPVPE-SILT 212 GLLTYP L AADILLY + VP GEDQ QH+EL ++LA+ FNKKY + F +PE I Sbjct: 153 VSGLLTYPPLMAADILLYGTDLVPPGEDQKQHLELTRNLAERFNKKYNDIFTIPEVKIPK 212 Query: 213 SMKKVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKAVTDFTSEVTYDPAGRAGV 272 ++ SL DP KMSKSDP++ A + + D P+++ +K + AVTD V +D + GV Sbjct: 213 VGARIMSLNDPLKKMSKSDPNQKAYITLLDEPKQLEKKIKSAVTDSEGIVKFDKENKPGV 272 Query: 273 SNIVAVHAAVTGLSVEEVVRRSAGMNTARYKLAVADAVIEKFAPIKREIEKLKLDKDHLE 332 SN++ +++ + ++EE+ + G +K +A+ V+ PI+ +L ++ + L+ Sbjct: 273 SNLLTIYSILGNTTIEELEAKYEGKGYGEFKGDLAEVVVNALKPIQDRYYEL-IESEELD 331 Query: 333 KVLQIGSAKAKELAYTVCQEVKKLVGF 359 ++L G+ +A A + ++++ +G Sbjct: 332 RILDEGAERANRTANKMLKKMENAMGL 358 >3U1V-A nrPDB Length = 338 Score = 223 bits (569), Expect = 8e-59, Method: Compositional matrix adjust. Identities = 120/326 (36%), Positives = 197/326 (60%), Gaps = 4/326 (1%) Query: 35 KRVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSVLYSIVDLHSITVPQDPAVLRQSILD 94 K +FS I PTG++ +G Y+GA+ +V LQ EY+ + I D +ITV QDP LRQ+I Sbjct: 2 KTIFSAICPTGVITIGRYIGALRQFVELQHEYN-CYFCIADQSAITVWQDPHELRQNIRR 60 Query: 95 MTAVLLACGINPEKSILFQQSQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHDGT 154 + A+ LA GI+P ++ LF S+V H Q +W+L C+V + L+ + +K + + K + Sbjct: 61 LAALYLAVGIDPTQATLFIASEVPAHAQAAWMLQCIVYIGELERMTLFK-ELSAGKEAVS 119 Query: 155 VGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQDLAQGFNKKYGEFFPVPESILTSM 214 GLLT+P + AA ILLY + VPVGE Q EL +DLA+ FNK+YGE F +PE+ + + Sbjct: 120 AGLLTHPPIYAAMILLYNTDIVPVGEYGKQLYELTRDLAERFNKRYGELFTIPEARIPKV 179 Query: 215 -KKVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKAVTDFTSEVTYDPAGRAGVS 273 ++ SL DP+ M +SDP+ A + + D + I +K + AVTD + YD + G+S Sbjct: 180 GARIMSLVDPTKSMYQSDPNPKAYITLLDDAKTIEKKIKSAVTDSEGTIRYDKEAKPGIS 239 Query: 274 NIVAVHAAVTGLSVEEVVRRSAGMNTARYKLAVADAVIEKFAPIKREIEKLKLDKDHLEK 333 N++ +++ ++G S+EE+ R+ G +K +A VIE PI+ ++ + L++ Sbjct: 240 NLLNIYSTLSGQSIEELERQYEGKGYGVFKADLAQVVIETLRPIQERYHHW-MESEELDR 298 Query: 334 VLQIGSAKAKELAYTVCQEVKKLVGF 359 VL G+ KA +A + +++++ +G Sbjct: 299 VLDEGAEKANRVASEMVRKMEQAMGL 324 >2EL7-A nrPDB Length = 337 Score = 211 bits (537), Expect = 4e-55, Method: Compositional matrix adjust. Identities = 131/333 (39%), Positives = 189/333 (56%), Gaps = 13/333 (3%) Query: 35 KRVFSGIQPTGILHLGNYLGAIESWVRLQDEYD-SVLYSIVDLHSITVP--QDPAVLRQS 91 KRV SGIQP+G +H+GNYLGAI+ WV + ++ + IVD H++T P DP+ L Q Sbjct: 2 KRVLSGIQPSGEIHIGNYLGAIKQWVAIGEKLGRDAFFCIVDYHALTNPLAYDPSTLAQR 61 Query: 92 ILDMTAVLLACGINPEKSILFQQSQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKH 151 + V +A G++PEK LF QS V EHT+LSW+ + + L L + Q+K K +KQ+ Sbjct: 62 TFEAALVNIAAGLDPEKVTLFVQSHVPEHTELSWVFTTLTPLGDLTRMTQFKDKASKQE- 120 Query: 152 DGTV--GLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQDLAQGFNKKYGEFFPVPES 209 TV GLL YPVLQAADIL+YK+ VPVGEDQVQH+EL +++A+ FN +GE FP P++ Sbjct: 121 --TVWSGLLMYPVLQAADILIYKADTVPVGEDQVQHIELTREIARRFNHLFGETFPEPQA 178 Query: 210 ILTSMKKVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKAVTDFTSEVTYDPAG- 268 +L D AKMSKS + T+ + + E I QK + D DP Sbjct: 179 LLNPEAPRVPGIDGKAKMSKSLGN---TIGLLEPEESIWQKIQHLPDDPQRIRLSDPGDP 235 Query: 269 -RAGVSNIVAVHAAVTGLSVEEVVRRSAGMNTARYKLAVADAVIEKFAPIKREIEKLKLD 327 R + ++ A + + R AG+ T K + D ++E PI+ E LK D Sbjct: 236 ERTILFTYLSYFAPKDLVEALKEEYRKAGVGTYVVKRILFDHLMEALRPIRERAEALKKD 295 Query: 328 KDHLEKVLQIGSAKAKELAYTVCQEVKKLVGFL 360 D++ L G+ +A+ +A +EV++ VG L Sbjct: 296 PDYVMDALLEGAKRARAVAQATMEEVREKVGLL 328 >2YY5-A nrPDB Length = 348 Score = 196 bits (497), Expect = 2e-50, Method: Compositional matrix adjust. Identities = 114/331 (34%), Positives = 184/331 (55%), Gaps = 19/331 (5%) Query: 35 KRVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSVLYSIVDLHSITVPQDPAVLRQSILD 94 KR +GIQ +G HLGNYLG ++S + LQ++ ++ + DLHSITV P L+Q+ D Sbjct: 5 KRALTGIQASGKQHLGNYLGVMQSLIELQEQCQLFVF-VADLHSITVDFQPQALKQNNFD 63 Query: 95 MTAVLLACGINPEKSILFQQSQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKH--D 152 + LLA G++P+K+ LF QS + EH+ + +++ L LQ + Q+KAK +Q + Sbjct: 64 LVRTLLAVGLDPQKACLFLQSDLLEHSMMGYLMMVQSNLGELQRMTQFKAKKAEQTRNPN 123 Query: 153 GTV----GLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQDLAQGFNKKYGEFFPVPE 208 GT+ GLLTYP L A DILLY+ VPVG DQ QH+EL +DLAQ KK+ +P+ Sbjct: 124 GTLNIPTGLLTYPALMAGDILLYQPDIVPVGNDQKQHLELTRDLAQRIQKKFKLKLRLPQ 183 Query: 209 SILT-SMKKVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKAVTDFTSEVTYDPA 267 + ++ L DP+ KMSKS ++ + + D E +V+K R+A TD +++ + Sbjct: 184 FVQNKDTNRIMDLFDPTKKMSKSSKNQNGVIYLDDPKEVVVKKIRQATTDSFNKIRFASK 243 Query: 268 GRAGVSNIVAVHAAVTGLSVEEVVRRSAGMNTARY---------KLAVADAVIEKFAPIK 318 + GV+N++ + A+ V + + G + Y K A+ +A + I+ Sbjct: 244 TQPGVTNMLTILKALLKEPVNQSLTNQLGNDLEAYFSTKSYLDLKNALTEATVNLLVNIQ 303 Query: 319 REIEKLKLDKDHLEKVLQIGSAKAKELAYTV 349 R+ E ++ ++ + LQ G +A+ A T Sbjct: 304 RKRE--QISREQVFNCLQAGKNQAQATARTT 332 >2G36-A nrPDB Length = 340 Score = 192 bits (487), Expect = 2e-49, Method: Compositional matrix adjust. Identities = 118/333 (35%), Positives = 185/333 (55%), Gaps = 15/333 (4%) Query: 36 RVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSVLYSIVDLHSITVPQDP-AVLRQSILD 94 R+ SG++PTG LH+G+ +GA+E+WV+LQ+E + Y + D H++T D + L++ D Sbjct: 14 RILSGMRPTGKLHIGHLVGALENWVKLQEEGNECFYFVADWHALTTHYDDVSKLKEYTRD 73 Query: 95 MTAVLLACGINPEKSILFQQSQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHD-- 152 + LACGI+PEKS++F QS V EH +L+ + S +V + RL+ + +K ++ + Sbjct: 74 LVRGFLACGIDPEKSVIFVQSGVKEHAELALLFSMIVSVSRLERVPTYKEIKSELNYKDL 133 Query: 153 GTVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQDLAQGFNKKYGEFFPVPESILT 212 T G L YPVLQAADIL+YK+ VPVGEDQV H+EL +++A+ FN Y E FP PE+IL+ Sbjct: 134 STAGFLIYPVLQAADILIYKAEGVPVGEDQVYHIELTREIARRFNYLYDEVFPEPEAILS 193 Query: 213 SMKKVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKAVTDFTSEVTYDPAGRAGV 272 + K+ KMSKS + + + S +E+ Q + +TD DP G Sbjct: 194 RVPKLPGT--DGRKMSKSYGN---IINLEISEKELEQTILRMMTDPARVRRSDP-GNPEN 247 Query: 273 SNIVAVHAAVTGLSVEEVVRRSAGMNTARYKLAVADAVI-----EKFAPIKREIEKLKLD 327 + H A +S EE G TA ++ K API K+ D Sbjct: 248 CPVWKYHQAFD-ISEEESKWVWEGCTTASIGCVDCKKLLLKNMKRKLAPIWENFRKIDED 306 Query: 328 KDHLEKVLQIGSAKAKELAYTVCQEVKKLVGFL 360 +++ V+ G+ KA+E+A +EV++ + + Sbjct: 307 PHYVDDVIMEGTKKAREVAAKTMEEVRRAMNLM 339 >3TZL-A nrPDB Length = 322 Score = 170 bits (431), Expect = 8e-43, Method: Compositional matrix adjust. Identities = 107/326 (32%), Positives = 175/326 (53%), Gaps = 10/326 (3%) Query: 36 RVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSVLYSIVDLHSITVPQDPAVLRQSILDM 95 RV +G+QP+G LH+GNY GAI+ V Q++ ++ I + H++T QD L+Q+ L Sbjct: 5 RVLTGLQPSGDLHIGNYFGAIKQMVDAQEKSQMFMF-IANYHAMTSSQDGEKLKQNSLKA 63 Query: 96 TAVLLACGINPEKSILFQQSQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHDGTV 155 A L+ GI+P+KS+ + QS V E +L WILS + L+ H +K K K + Sbjct: 64 AAAFLSLGIDPQKSVFWLQSDVKEVMELYWILSQFTPMGLLERAHSYKDKVAK-GLSASH 122 Query: 156 GLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQDLAQGFNKKYGEFFPVPESILTSMK 215 GL +YPVL AADILL+ + VPVG+DQ+QH+E+ +D+A N ++GE F +PE+ + Sbjct: 123 GLFSYPVLMAADILLFDTRIVPVGKDQIQHVEIARDIALKVNNEWGEIFTLPEARVNEEV 182 Query: 216 KVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKAVTDFTSEVTYDPAG--RAGVS 273 V D AKMSKS + T+ I S + + ++ VTD T+ DP + Sbjct: 183 AVVVGTD-GAKMSKSYQN---TIDIFSSEKTLKKQISSIVTDSTA--LEDPKDHENCNIF 236 Query: 274 NIVAVHAAVTGLSVEEVVRRSAGMNTARYKLAVADAVIEKFAPIKREIEKLKLDKDHLEK 333 I + +G ++ G +K+ + + V F + + +L HL++ Sbjct: 237 KIAKLFLDESGQKELQIRYEKGGEGYGHFKIYLNELVNAYFKEAREKYNELLEKPSHLKE 296 Query: 334 VLQIGSAKAKELAYTVCQEVKKLVGF 359 +L G+ KA+++A Q++ + +G Sbjct: 297 ILDFGATKARKIAQEKMQKIYEKIGL 322 >6MTK-A nrPDB Length = 329 Score = 168 bits (426), Expect = 3e-42, Method: Compositional matrix adjust. Identities = 109/330 (33%), Positives = 176/330 (53%), Gaps = 16/330 (4%) Query: 36 RVFSGIQPTGILHLGNYLGAIESWVRL--QDEYDSVLYSIVDLHSITVPQDPAVLRQSIL 93 R+ +GIQ TG HLGN LGAI + L + E DS L+ I +LH++T +D A LRQ+ Sbjct: 10 RILTGIQATGTPHLGNLLGAIIPAIELAKKPENDS-LFFIANLHTLTQIKDAAQLRQNTY 68 Query: 94 DMTAVLLACGINPEKSILFQQSQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHDG 153 ++ A LACG++ EK+I ++QS + E +L+W L C RL H +K K + + D Sbjct: 69 EIAAAWLACGLDTEKTIFYRQSDIPETCELTWYLDCFFPFQRLTLAHSFKDKADRLQ-DV 127 Query: 154 TVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQDLAQGFNKKYGEFFPVPESILTS 213 GL YP+L AADILLY + VPVG+DQ+QH+E+ +D+A+ FN++ GE F +P + + Sbjct: 128 NAGLFNYPILMAADILLYDAEVVPVGKDQLQHLEITRDVAEKFNRQMGEVFVLPGAEIQE 187 Query: 214 MKKVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKAVTDFTS-EVTYDPAGRAGV 272 K D KMSKS + + I +E+ ++ +D S E DP Sbjct: 188 STKYVPGTD-GHKMSKSRGN---IINIFLPEKELKKQIMSIESDSKSLEEPKDPE----T 239 Query: 273 SNIVAVHAAVTGLSVEEVVRR---SAGMNTARYKLAVADAVIEKFAPIKREIEKLKLDKD 329 ++A + E +R+ + K + + ++E+FA + + + Sbjct: 240 DKTFIIYALIATPEQTEALRQKYLAGNFGYGHAKTELLNLILERFAKERELFSYYMSNLN 299 Query: 330 HLEKVLQIGSAKAKELAYTVCQEVKKLVGF 359 LE+ LQ G+ KA+ +A + +K++G+ Sbjct: 300 ELEEKLQQGAEKARVIARATLDKTRKVLGY 329 >6NCR-A nrPDB Length = 354 Score = 140 bits (353), Expect = 7e-34, Method: Compositional matrix adjust. Identities = 105/339 (30%), Positives = 172/339 (50%), Gaps = 20/339 (5%) Query: 34 KKRVFSGIQPTGILHLGNYLGAIESWVRLQDE--YDSVLYSIVDLHSITVPQDPAVLRQ- 90 KKRV +G +PTG LHLG+++G+I + ++LQ++ YD + I DLH++T + Q Sbjct: 11 KKRVLTGDRPTGKLHLGHWIGSIMNRLQLQNDSRYD-CFFIIADLHTLTTKTRKEEILQI 69 Query: 91 --SILDMTAVLLACGINPEKSILFQQSQVSEHTQLSWILSCMVRLPRLQHLHQWKA---K 145 I D+ A L+ GI+PEKS ++ QS + E +L+ I S + L + + K Sbjct: 70 DNHIYDVLADWLSVGIDPEKSAIYLQSAIPEIYELNLIFSMLTPLNHIMGIPSIKEMARN 129 Query: 146 TTKQKHDGTVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQDLAQGFNKKYGEFFP 205 + + + GL+ YPVLQ+ADILL K+ VPVG+D H+EL +D+A+ FN+ YGE FP Sbjct: 130 ASLNEESLSHGLIGYPVLQSADILLAKAHLVPVGKDNEAHVELTRDIAKTFNRLYGEVFP 189 Query: 206 VPESILTSMKKVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKAVTDFTSEVTYD 265 P+ + + + + KMSKS + + ++D + + +K RK TD Sbjct: 190 EPDILQGELTALVGT-NGQGKMSKSANN---AIYLSDDAKTVQEKIRKLYTDPNRIHATT 245 Query: 266 PAGRAGVSNIVAVHAAVTGLSVEEVVR-----RSAGMNTARYKLAVADAVIEKFAPIKRE 320 P G N + ++ + EEV R + K +A+ + P + + Sbjct: 246 PGRVEG--NPLFIYHDLFNPHKEEVEEFKTRYRQGCIRDVEVKARLAEEINLFLNPFREK 303 Query: 321 IEKLKLDKDHLEKVLQIGSAKAKELAYTVCQEVKKLVGF 359 +L LE+ LQ G+ K + +A +EV +G Sbjct: 304 RSELVAQPKFLEEALQQGTEKMRTVARETMEEVHDHLGL 342 >5TEW-A nrPDB Length = 344 Score = 137 bits (346), Expect = 5e-33, Method: Compositional matrix adjust. Identities = 100/338 (29%), Positives = 172/338 (50%), Gaps = 20/338 (5%) Query: 33 SKKRVFSGIQPTGILHLGNYLGAIESWVRLQDEYD--SVLYSIVDLHSITVPQDPAVLRQ 90 SKKRV +G+ TG HLGNY+GAI VR D S L+ + D H I + ++ Q Sbjct: 10 SKKRVLTGVTTTGTPHLGNYVGAIRPAVRAAQNPDTESFLF-LADYHGIIKCHEQEMIHQ 68 Query: 91 SILDMTAVLLACGINPEKSILFQQSQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQK 150 S + A LACG++PE++ ++QS + E +L+WIL+C+ + H +KA Sbjct: 69 STQAVAATWLACGLDPERTTFYRQSDIPEVMELNWILTCITAKGLMNRAHAYKAAVQANA 128 Query: 151 HDG--------TVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQDLAQGFNKKYGE 202 +G +GL +YP+L ADIL++ + VPVG DQ+QH+E+ +D+A FN ++ E Sbjct: 129 ENGQEDPDFGVEMGLFSYPILMTADILMFNANEVPVGRDQIQHVEMARDIAGRFNHRFQE 188 Query: 203 FFPVPESILTSMKKVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKAVTDFTSEV 262 F +PE + ++ D KMSKS + T+ + ++ ++ + K +T+ Sbjct: 189 LFTLPEVKIDENVELLVGLD-GRKMSKSYGN---TIPLWENDKKTQKSVNKIITNMKE-- 242 Query: 263 TYDPAGRAGVSNIVAVHAAVTGLS--VEEVVRRSAGMNTARYKLAVADAVIEKFAPIKRE 320 +P + S + ++ A + S E + G+ K A + + A ++ Sbjct: 243 PGEPK-QPDESPLFEIYKAFSTPSETAEFTQMLADGLAWGEAKKLSAAKINAELAELRER 301 Query: 321 IEKLKLDKDHLEKVLQIGSAKAKELAYTVCQEVKKLVG 358 L + +E++LQ G+ KA++ A + +V+ VG Sbjct: 302 YNALTSNPSQIEEILQAGAQKARKEARELLDKVRDAVG 339 >1YID-B nrPDB Length = 351 Score = 125 bits (314), Expect = 3e-29, Method: Compositional matrix adjust. Identities = 92/325 (28%), Positives = 167/325 (51%), Gaps = 11/325 (3%) Query: 37 VFSGIQPTGILHLGNYLGAIESWVRLQDEYDSVLYSIVDLHSITVPQD-PAVLRQSILDM 95 V +G +PTG LHLG+ G++++ VRLQDE + + + D+ ++T D P +R+++L + Sbjct: 25 VLTGDRPTGALHLGHLAGSLQNRVRLQDEAE-LFVLLADVQALTDHFDRPEQVRENVLAV 83 Query: 96 TAVLLACGINPEKSILFQQSQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHDGTV 155 LA G++P+K+ QS V E +L+ +V + L+ KA+ ++ + V Sbjct: 84 ALDYLAAGLDPQKTTCVVQSAVPELAELTVYFLNLVTVSHLRQNPTVKAEIAQKGYGERV 143 Query: 156 --GLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQDLAQGFNKKYGEFFPVPESILTS 213 G YPV QAADI + +T VPVG+DQ+ +E +++ + FN Y P++ L+ Sbjct: 144 PAGFFVYPVSQAADIAAFGATLVPVGDDQLPMLEQTREIVRRFNALYAPVLAEPQAQLSR 203 Query: 214 MKKVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKAVTDFTSEVTYDPAGRAGVS 273 + ++ L D AKMSKS + +A + DS +E+ +K TD DP G Sbjct: 204 VPRLPGL-DGQAKMSKSLGNAIA---LGDSADEVARKVMGMYTDPGHLRASDPGRVEGNP 259 Query: 274 NIVAVHAAVTGLSVEEVVR---RSAGMNTARYKLAVADAVIEKFAPIKREIEKLKLDKDH 330 + A + + ++ R+ G+ + K + D + API+ + + D D Sbjct: 260 VFTFLDAFDPDPARVQALKDQYRAGGLGDVKVKKHLIDVLNGVLAPIRTRRAEYERDPDA 319 Query: 331 LEKVLQIGSAKAKELAYTVCQEVKK 355 + + + G+A+ +E+A +V++ Sbjct: 320 VLRFVTEGTARGREVAAQTLGQVRR 344 >3A04-A nrPDB Length = 372 Score = 57.8 bits (138), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 62/237 (26%), Positives = 103/237 (43%), Gaps = 42/237 (17%) Query: 37 VFSGIQPTGILHLGNYLGAIESWVRLQDEYDSVLYSIVDLHSITVPQ--DPAVLRQSILD 94 V +G P+G H G+ L ++ + LQ V +I D + V + +R ++ + Sbjct: 73 VLTGFMPSGKFHFGHKL-TVDQLIYLQKNGFKVFVAIADAEAFAVRRIGREEAVRIAVEE 131 Query: 95 MTAVLLACGINPEKSILFQQSQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHDGT 154 A ++A G++P+ + + Q+ P + + + K T + + Sbjct: 132 YIANMIALGLDPKDTEFYFQTNRGT--------------PYFRLIQLFSGKVTAAEMEAI 177 Query: 155 VGLLT-----YPVLQAADILL--------YKSTHVPVGEDQVQHMELVQDLAQGFNKKYG 201 G LT + QAADIL Y+ VPVG DQ H+ L +DLA ++ G Sbjct: 178 YGELTPAKMMASLTQAADILHVQLDEYGGYRHVVVPVGADQDPHLRLTRDLA---DRMAG 234 Query: 202 --EFFPVPESILTSMKKVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKAVT 256 E E ++ K++ D KMS S PD +T+ +TD PE K +A+T Sbjct: 235 VVEL----ERPASTYHKLQPGLD-GRKMSSSRPD--STIFLTDPPEVARNKLFRALT 284 >3JXE-A nrPDB Length = 392 Score = 55.5 bits (132), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 53/225 (23%), Positives = 104/225 (46%), Gaps = 36/225 (16%) Query: 37 VFSGIQPTGILHLGNYLGAIES-WVRLQDEYDSVLY-SIVD------LHSITVPQDPAVL 88 +++G P+G +H+G+ + + W LQ+++ LY I D ++T Sbjct: 76 LYTGRGPSGPMHIGHIIPFFATKW--LQEKFGVNLYIQITDDEKFLFKENLTFDDTKRWA 133 Query: 89 RQSILDMTAVLLACGINPEKSILFQQSQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTTK 148 +ILD+ AV G +P+K+ +FQ S+ ++ +++ ++ + + + + ++ Sbjct: 134 YDNILDIIAV----GFDPDKTFIFQNSEFTKIYEMAIPIAKKINFSMAKAVFGFTEQS-- 187 Query: 149 QKHDGTVGLLTYPVLQAADILL-YKSTHVPVGEDQVQHMELVQDLAQ--GFNKKYGEFFP 205 +G++ +P +Q A K +P DQ + L +D A+ G+ K Sbjct: 188 -----KIGMIFFPAIQIAPTFFERKRCLIPAAIDQDPYWRLQRDFAESLGYYK------- 235 Query: 206 VPESILTSMKKVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQK 250 + K V SL S KMS S P+ + +TDSPE++ +K Sbjct: 236 ---TAALHSKFVPSLTSLSGKMSASKPE--TAIYLTDSPEDVEKK 275 >3P0I-A nrPDB Length = 690 Score = 50.1 bits (118), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 58/272 (21%), Positives = 120/272 (44%), Gaps = 26/272 (9%) Query: 11 ERWSFIRALHKGSAAAPALQKDSKK----RVFSGIQPTGILHLGNYLGAIESWVRLQDEY 66 ER+ +R++ + L+ +K R + G +P+G +H+ + + + Sbjct: 13 ERYKLLRSVGEECIQESELRNLIEKKPLIRCYDGFEPSGRMHIAQGIFKAVNVNKCTAAG 72 Query: 67 DSVLYSIVDLHSIT---VPQDPAVLRQSILDMTAVLLACGINPEKSI-LFQQSQVSEHTQ 122 ++ + D ++ V + +R + V A G++ +K + L+ +++ H Sbjct: 73 CEFVFWVADWFALMNDKVGGELEKIRIVGRYLIEVWKAAGMDMDKVLFLWSSEEITSHAD 132 Query: 123 LSWILSCMVRLPRLQHLHQWK-AKTTKQKHDGTV--GLLTYPVLQAADILLYKSTHVPVG 179 W + ++ + R + + K T K +GT+ + YP++Q DI K+ +G Sbjct: 133 TYWRM--VLDIGRQNTIARIKKCCTIMGKTEGTLTAAQVLYPLMQCCDIFFLKADICQLG 190 Query: 180 EDQVQHMELVQDLAQGFNKKYGEFFPVPESILTSMKKVKSLRDPSAKMSKSDPDKLATVR 239 DQ + L ++ +K + ++ S + L+ AKMSKSDPD + + Sbjct: 191 LDQRKVNMLAREYCDLIGRKL-------KPVILSHHMLAGLKQGQAKMSKSDPD--SAIF 241 Query: 240 ITDSPEEIVQKFRKA----VTDFTSEVTYDPA 267 + D+ E++ +K R+A V S +T D A Sbjct: 242 MEDTEEDVARKIRQAYCPRVKQSASAITDDGA 273 >2CYB-A nrPDB Length = 323 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 59/245 (24%), Positives = 107/245 (43%), Gaps = 32/245 (13%) Query: 29 LQKDSKKRVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSVLYSIVDLHSITVPQDPAVL 88 ++ K R + G +P+G +HLG+ + ++ + LQ+ ++ + D+H+ + Sbjct: 27 IETKEKPRAYVGYEPSGEIHLGHMM-TVQKLMDLQEAGFEIIVLLADIHAYLNEKGTFEE 85 Query: 89 RQSILDMTA-VLLACGINPEKS--ILFQQSQVSEHTQLSWILSCMVRLPRLQHLHQWKAK 145 + D V +A G++ ++ +L + Q+S L + M R+ L + + Sbjct: 86 IAEVADYNKKVFIALGLDESRAKFVLGSEYQLSRDYVLDVL--KMARITTLNRARRSMDE 143 Query: 146 TTKQKHDGTVGLLTYPVLQAADILLYKSTHVPVGEDQVQ-HMELVQDLAQ-GFNKKYGEF 203 +++K D V + YP++QA DI G DQ + HM ++L + G++ Sbjct: 144 VSRRKEDPMVSQMIYPLMQALDIAHLGVDLAVGGIDQRKIHMLARENLPRLGYSSPVCLH 203 Query: 204 FPVPESILTSMKKVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKAVTDFTSEVT 263 P IL + KMS S K + + D PEE+ +K RKA Sbjct: 204 TP----ILVGLD--------GQKMSSS---KGNYISVRDPPEEVERKIRKA--------- 239 Query: 264 YDPAG 268 Y PAG Sbjct: 240 YCPAG 244 >2CYC-A nrPDB Length = 375 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 65/200 (32%), Positives = 85/200 (42%), Gaps = 39/200 (19%) Query: 158 LTYPVLQAADILLYKSTHVPVGEDQ----VQHMELVQDLAQGFNKKYGEFF-PV------ 206 L YP++Q ADI T G DQ V +E+ Q L GE PV Sbjct: 166 LIYPMMQVADIFYQGVTIAHAGMDQRKAHVIAIEVAQKLRYHPIVHEGEKLKPVAVHHHL 225 Query: 207 -------PESILTSMKKVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKAVTDFT 259 P+ + S ++ K ++ KMSKS P + V I DSPEEI QK RKA Sbjct: 226 LLGLQEPPKWPIESEEEFKEIK-AQMKMSKSKP--YSAVFIHDSPEEIRQKLRKAFCP-A 281 Query: 260 SEVTYDPAGRAGVSNIV--------AVH------AAVTGLSVEEVVRRSA--GMNTARYK 303 EV Y+P V I+ VH VT + EE+ R A ++ K Sbjct: 282 REVRYNPV-LDWVEYIIFREEPTEFTVHRPAKFGGDVTYTTFEELKRDFAEGKLHPLDLK 340 Query: 304 LAVADAVIEKFAPIKREIEK 323 AVA+ +I PI+R EK Sbjct: 341 NAVAEYLINLLEPIRRYFEK 360 >5NSF-B nrPDB Length = 318 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 74/315 (23%), Positives = 134/315 (42%), Gaps = 54/315 (17%) Query: 29 LQKDSKKRVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSVLYSIVDLHSITVPQDPAVL 88 L+KD K G +P+G +HLG+YL I+ + LQ+ ++ + DL + + Sbjct: 36 LKKDEKSAGI-GFEPSGKIHLGHYL-QIKKMIDLQNAGFDIIIWLADLGAYLNQKGELDE 93 Query: 89 RQSILDMT-AVLLACGINPEKSILFQQSQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTT 147 + I D V A G+ + + + ++T + L+ L R + + A Sbjct: 94 IRKIGDYNKKVFEAMGLKAKYVYGSEHNLDKDYTLNVYRLALKTTLKRARRSMELIA--- 150 Query: 148 KQKHDGTVGLLTYPVLQAADILLYKSTHVPVG--EDQVQHMELVQDLAQGFNKKYGEFFP 205 ++ + V + YP++Q + + Y V VG E + HM L ++L Sbjct: 151 REDENPKVAEVIYPIMQ-VNAIHYNGVDVAVGGMEQRKIHM-LAREL------------- 195 Query: 206 VPESILTSMKKVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKAVTDFTSEVTYD 265 +P+ ++ V + D KMS S + +A + DSPEEI K +KA Y Sbjct: 196 LPKKVVCIHNPVLTGLDGEGKMSSSKGNFIA---VDDSPEEIRAKIKKA---------YC 243 Query: 266 PAGRAGVSNIVAV-----------------HAAVTGLSVEEV--VRRSAGMNTARYKLAV 306 PAG + I+ + +T S EE+ + ++ ++ R K AV Sbjct: 244 PAGVVEGNPIMEIAKYFLEYPLTIKRPEKFGGDLTVNSYEELESLFKNKELHPMRLKNAV 303 Query: 307 ADAVIEKFAPIKREI 321 A+ +I+ PI++ + Sbjct: 304 AEELIKILEPIRKRL 318 >3FOC-A nrPDB Length = 451 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 43/158 (27%), Positives = 74/158 (46%), Gaps = 24/158 (15%) Query: 37 VFSGIQPT-GILHLGNYLGAIESWVRLQDEYDS-VLYSIVD------LHSITVPQDPAVL 88 +++G P+ G LHLG+ L I + LQD + V+ I D S++ + + Sbjct: 94 IYTGRGPSSGALHLGHLLPFIFTKY-LQDAFKCYVVIQITDDEKFLRNRSLSYAEVDSYT 152 Query: 89 RQSILDMTAVLLACGINPEKSILFQQSQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTTK 148 R++I D ++ACG +P+K+ +F SQ + + SC+V R+ + Q +A + Sbjct: 153 RENIKD----IIACGFDPDKTFIFINSQYLS-LKNRYRFSCLVD--RMLPISQLRA-SFG 204 Query: 149 QKHDGTVGLLTYPVLQAA-------DILLYKSTHVPVG 179 +D VG +P Q D L + +PVG Sbjct: 205 FSNDANVGYAAFPPKQMLPVYSTYFDGLPFTRVPLPVG 242 >2J5B-A nrPDB Length = 348 Score = 40.0 bits (92), Expect = 0.001, Method: Compositional matrix adjust. Identities = 54/248 (21%), Positives = 100/248 (40%), Gaps = 45/248 (18%) Query: 38 FSGIQPTGILHLGNYLGAIESWVRLQDEYDSVLYSIVDLH---SITVPQDPAVLRQSILD 94 ++G +P+G +H+ L + + + + ++ I D ++ + D +R+ Sbjct: 44 YNGFEPSGRIHIAQALITVMNTNNMIECGGQMIIYIADWFAKMNLKMNGDINKIRELGRY 103 Query: 95 MTAVLLACGINPEKSILFQQSQ--------------VSEHTQLSWILSCMVRLPRLQHLH 140 V ACGIN + + S+ ++E + +S + C Q + Sbjct: 104 FIEVFKACGINLDGTRFIWASEFIASNPSYIERMLDIAEFSTISRVKRC------CQIMG 157 Query: 141 QWKAKTTKQKHDGTVGLLTYPVLQAADILLYKSTHVPVGEDQVQ---HMELVQDLAQGFN 197 + ++ K + YP +QAAD+ VP G D Q V LA + Sbjct: 158 RNESDCLKASQ------IFYPCMQAADVF----ELVPEGIDICQLGIDQRKVNMLAIEYA 207 Query: 198 KKYGEFFPVPESILTSMKKVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKAVTD 257 G P+ S + SL P KMSKSDP + + D+ +E+ +K +A Sbjct: 208 NDRGLKIPIS----LSHHMLMSLSGPKKKMSKSDPQ--GAIFMDDTEQEVSEKISRA--- 258 Query: 258 FTSEVTYD 265 + ++ T+D Sbjct: 259 YCTDETFD 266 >2CYA-A nrPDB Length = 364 Score = 36.6 bits (83), Expect = 0.017, Method: Compositional matrix adjust. Identities = 57/253 (22%), Positives = 115/253 (45%), Gaps = 45/253 (17%) Query: 29 LQKDSKKRVFSGIQPTGILHLGNYLGAIESWV-RLQDEYDS-VLYSIVD--LHSIT---V 81 L ++ + + G +P+G+ H+G + W+ +++D ++ V +S+++ H+ + Sbjct: 30 LASGARIKGYIGYEPSGVAHIGWLV-----WMYKVKDLVEAGVDFSVLEATWHAYINDKL 84 Query: 82 PQDPAVLRQSILDMTAVLLACGINPEKSILFQQSQVSEHTQLSWILSCMVRLPRLQHLHQ 141 D ++R + + V+ A G+ P + + F ++ + W L ++R+ + L + Sbjct: 85 GGDMDLIRAAARIVRRVMEAAGV-PVERVRFVDAEELASDKDYWGL--VIRVAKRASLAR 141 Query: 142 WKAKTT---KQKHDGTVGL--LTYPVLQAADILLYKSTHVPVGEDQVQHMELVQDLAQGF 196 + T ++ + V L YP++Q +DI G DQ + L +D+A+ Sbjct: 142 VRRALTIMGRRAEEAEVDASKLIYPLMQVSDIFYMDLDIALGGMDQRKAHMLARDVAEKL 201 Query: 197 NKKYGEFFPVPESILTSMKKVKSLRDPS---------------AKMSKSDPDKLATVRIT 241 +K P +I T + + SL+ P KMSKS P+ V + Sbjct: 202 GRKK------PVAIHTPI--ISSLQGPGRMEASQGEIDDVLAEVKMSKSKPE--TAVFVV 251 Query: 242 DSPEEIVQKFRKA 254 DS ++I +K RKA Sbjct: 252 DSDDDIRRKIRKA 264 >4J75-A nrPDB Length = 409 Score = 35.4 bits (80), Expect = 0.043, Method: Compositional matrix adjust. Identities = 37/169 (21%), Positives = 75/169 (44%), Gaps = 20/169 (11%) Query: 99 LLACGINPEKSILFQQSQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHDGTVGLL 158 +++ G+NPE + +F+ ++ + ++ ++ + + L+Q H +G + Sbjct: 147 IISVGLNPELTFIFKNTEYA-----GYLYPTVLSIHKKTTLNQ-SMNVFGFNHSDNIGKI 200 Query: 159 TYPVLQAADIL-------LYKS--THVPVGEDQVQHMELVQDLA--QGFNKK---YGEFF 204 +YP Q A L K+ VP G DQ + L +D+A +K + F Sbjct: 201 SYPSFQIAPCFSQCFPNFLGKNIPCLVPQGIDQDPYFRLSRDIAVKMALHKPVVVHSVFM 260 Query: 205 PVPESILTSMKKVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRK 253 P + + + M K +D + K + + + + +TD+PE+I K K Sbjct: 261 PGLQGVNSKMSSTKKKKDDNGKSNSTFDHNNSVIFLTDTPEQIKNKINK 309 >3VGJ-A nrPDB Length = 373 Score = 33.1 bits (74), Expect = 0.20, Method: Compositional matrix adjust. Identities = 48/229 (20%), Positives = 99/229 (43%), Gaps = 25/229 (10%) Query: 37 VFSGIQPTGILHLGNYLGAIESWV--RLQDEYDSVLYSIVDLH---SITVPQDPAVLRQS 91 + G +P+G +H+ G ++S + +L + ++ I D + + D +++ Sbjct: 59 CYDGFEPSGRMHIAQ--GLLKSIIVNKLTSNGCTFIFWIADWFAHLNNKMSGDLKKIKKV 116 Query: 92 ILDMTAVLLACGINPEK-SILFQQSQVSEHTQLSWIL----SCMVRLPRLQHLHQWKAKT 146 V +CG+N E L+ ++++ W L S + R++ + ++ Sbjct: 117 GSYFIEVWKSCGMNMENVQFLWASEEINKKPNEYWSLVLDISRSFNINRMKRCLKIMGRS 176 Query: 147 TKQKHDGTVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQDLAQGF-NKKYGEFFP 205 + + + YP +Q ADI +G DQ + V LA+ + + K + P Sbjct: 177 --EGEENYCSQILYPCMQCADIFFLNVDICQLGIDQRK----VNMLAREYCDIKKIKKKP 230 Query: 206 VPESILTSMKKVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKA 254 V + S + L + KMSKSD + + + + DS ++ +K +KA Sbjct: 231 V----ILSHGMLPGLLEGQEKMSKSDEN--SAIFMDDSESDVNRKIKKA 273 >3HV0-A nrPDB Length = 393 Score = 31.6 bits (70), Expect = 0.63, Method: Compositional matrix adjust. Identities = 43/171 (25%), Positives = 70/171 (40%), Gaps = 37/171 (21%) Query: 99 LLACGINPEKSILFQQSQVSEHTQLSWILSC---MVRLPRLQHLHQWKAKTTKQKHDGTV 155 ++ACG +PE + +F T L +I ++R+ + Q K+ K V Sbjct: 142 IIACGFDPELTFIF--------TNLEYIAELYPDILRIEKKISCSQIKS-IFGFKDSCNV 192 Query: 156 GLLTYPVLQAADILLYKSTH-----------VPVGEDQVQHMELVQDLAQ--GFNKKYGE 202 G +P +QAA H VP DQ + +V+D+A G+ K Sbjct: 193 GKFAFPAVQAAPAFSSSFPHIFGGRTDIHCLVPHAIDQDPYFRMVRDVAPRLGYLK---- 248 Query: 203 FFPVPESILTSMKKVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRK 253 P SI + + SL+ KMS S + +++ + D+ E I K K Sbjct: 249 ----PSSIHSIF--LPSLQGSQTKMSASVQN--SSIFVNDNEESIRNKIMK 291 >1OUT-A nrPDB Length = 143 Score = 30.8 bits (68), Expect = 0.83, Method: Compositional matrix adjust. Identities = 20/66 (30%), Positives = 30/66 (45%), Gaps = 3/66 (4%) Query: 48 HLGNYLGAIESWVRLQDEYDSVLYSIVDLHSITVPQDPA---VLRQSILDMTAVLLACGI 104 H G +GAI V L D+ + ++ DLH+ + DP +L +IL A+ Sbjct: 60 HGGIIMGAIGKAVGLMDDLVGGMSALSDLHAFKLRVDPGNFKILSHNILVTLAIHFPSDF 119 Query: 105 NPEKSI 110 PE I Sbjct: 120 TPEVHI 125 >5IJO-H nrPDB Length = 522 Score = 28.9 bits (63), Expect = 3.3, Method: Compositional matrix adjust. Identities = 14/34 (41%), Positives = 22/34 (64%) Query: 312 EKFAPIKREIEKLKLDKDHLEKVLQIGSAKAKEL 345 EK + RE+EK+KLD+ L++ L ++ KEL Sbjct: 370 EKITSLHREVEKVKLDQKRLDQELDFILSQQKEL 403 >2PK3-A nrPDB Length = 321 Score = 28.9 bits (63), Expect = 3.9, Method: Compositional matrix adjust. Identities = 27/90 (30%), Positives = 42/90 (46%), Gaps = 11/90 (12%) Query: 35 KRVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSVLYSIVDLHSITVPQDPAVLRQSILD 94 K+V S I+P I HL +SW+ + + + ++ LH + +R S LD Sbjct: 67 KKVISDIKPDYIFHLAAKSSVKDSWLNKKGTFSTNVFGT--LHVLD------AVRDSNLD 118 Query: 95 MTAVLLACGINPEKS-ILFQQSQVSEHTQL 123 +L G + E IL ++S VSE QL Sbjct: 119 CR--ILTIGSSEEYGMILPEESPVSEENQL 146 >6N2O-A nrPDB Length = 573 Score = 28.5 bits (62), Expect = 4.8, Method: Compositional matrix adjust. Identities = 14/42 (33%), Positives = 22/42 (52%), Gaps = 1/42 (2%) Query: 160 YPVLQAADILLYKSTHVP-VGEDQVQHMELVQDLAQGFNKKY 200 YP+ A ++ Y +TH+P G D VQ + + +AQ Y Sbjct: 224 YPITPATEVAKYVATHLPKCGGDLVQAEDEIASIAQVLGASY 265 >4TN5-A nrPDB Length = 113 Score = 28.5 bits (62), Expect = 4.9, Method: Compositional matrix adjust. Identities = 21/88 (23%), Positives = 39/88 (44%), Gaps = 7/88 (7%) Query: 132 RLPRLQHLHQWKAKTTKQKHDGTVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQD 191 RL +L L +W Q GT L ++ AD+ L + G ++ +H VQ Sbjct: 23 RLEKLCLLEKWGVSIETQGALGTENRLADEDIRRADVALLITDIELAGAERFEHCRYVQC 82 Query: 192 LAQGFNKKYGEFFPVPESILTSMKKVKS 219 F ++ P+ ++++++KV S Sbjct: 83 SIYAFLRE-------PQRVMSAVRKVLS 103 >3HBA-A nrPDB Length = 334 Score = 28.1 bits (61), Expect = 6.7, Method: Compositional matrix adjust. Identities = 14/34 (41%), Positives = 22/34 (64%), Gaps = 2/34 (5%) Query: 75 DLHSITVPQDPAVLRQSILDMTAVLLACGINPEK 108 D+H P A+L++ +D+ AV +A GINP+K Sbjct: 292 DIHPRIAPL--ALLQRFYIDVAAVAIALGINPDK 323 >5D0U-A nrPDB Length = 714 Score = 27.7 bits (60), Expect = 7.2, Method: Compositional matrix adjust. Identities = 23/89 (25%), Positives = 38/89 (42%), Gaps = 6/89 (6%) Query: 203 FFPVPESILTSMKKVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKAVTDFTSEV 262 F E I + +++ D + S + P + + T P + + F KA F Sbjct: 254 FLTGEEEIEDACRRISLEVDEMIRESDAGPMSVYPLYGTLPPHQQQRIFEKAPQPFR--- 310 Query: 263 TYDPAGRAGVSNIVAVHAAVTGLSVEEVV 291 P GR G IVA + A T L+++ +V Sbjct: 311 ---PGGRPGRKCIVATNIAETSLTIDGIV 336 >3T97-C nrPDB Length = 64 Score = 27.3 bits (59), Expect = 9.4, Method: Compositional matrix adjust. Identities = 14/34 (41%), Positives = 22/34 (64%) Query: 312 EKFAPIKREIEKLKLDKDHLEKVLQIGSAKAKEL 345 EK + RE+EK+KLD+ L++ L ++ KEL Sbjct: 12 EKITSLHREVEKVKLDQKRLDQELDFILSQQKEL 45 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 5EKD-A nrPDB 433 e-122 6DFU-A nrPDB 424 e-119 5DK4-A nrPDB 422 e-118 5V0I-A nrPDB 421 e-118 3N9I-A nrPDB 418 e-117 3PRH-A nrPDB 399 e-111 3SZ3-A nrPDB 390 e-109 3U1V-A nrPDB 388 e-108 2EL7-A nrPDB 353 7e-98 2G36-A nrPDB 349 1e-96 6NCR-A nrPDB 330 4e-91 3TZL-A nrPDB 327 4e-90 2YY5-A nrPDB 324 5e-89 6MTK-A nrPDB 313 8e-86 1YID-B nrPDB 308 3e-84 5TEW-A nrPDB 298 2e-81 3P0I-A nrPDB 254 5e-68 5NSF-B nrPDB 206 1e-53 2CYB-A nrPDB 202 2e-52 2J5B-A nrPDB 198 3e-51 3JXE-A nrPDB 178 3e-45 3A04-A nrPDB 176 9e-45 2CYC-A nrPDB 171 5e-43 3FOC-A nrPDB 144 6e-35 Sequences not found previously or not previously below threshold: 3VGJ-A nrPDB 191 5e-49 2CYA-A nrPDB 144 7e-35 5UJI-A nrPDB 129 2e-30 1R6T-A nrPDB 127 7e-30 3HV0-A nrPDB 125 2e-29 3KT6-A nrPDB 120 9e-28 3I05-A nrPDB 115 3e-26 4J75-A nrPDB 114 5e-26 2DLC-X nrPDB 110 8e-25 3TZE-A nrPDB 105 3e-23 6BQZ-A nrPDB 85 6e-17 4Q93-A nrPDB 83 3e-16 6BYQ-A nrPDB 77 9e-15 1H3F-A nrPDB 72 3e-13 3HZR-A nrPDB 54 1e-07 2JA2-A nrPDB 39 0.003 3AKZ-B nrPDB 36 0.035 2CFO-A nrPDB 36 0.038 3AL0-C nrPDB 35 0.044 4GRI-A nrPDB 34 0.11 6Q8C-A nrPDB 34 0.13 2C54-A nrPDB 33 0.21 5K0S-A nrPDB 32 0.33 4G6Z-A nrPDB 32 0.37 2HZ7-A nrPDB 32 0.39 6BRL-A nrPDB 32 0.43 3AII-A nrPDB 32 0.51 5ZDO-A nrPDB 32 0.54 5H4V-A nrPDB 32 0.60 3SP1-A nrPDB 31 0.81 1IRX-A nrPDB 31 1.1 6B1P-A nrPDB 31 1.1 1YFI-A nrPDB 31 1.2 5IHX-A nrPDB 30 2.0 4H3S-A nrPDB 29 2.3 5TGT-A nrPDB 29 2.4 1QU3-A nrPDB 29 3.3 3BYH-B nrPDB 29 3.7 2R70-A nrPDB 29 4.0 4ZO7-A nrPDB 29 4.3 6E8G-S nrPDB 29 4.9 3FRR-A nrPDB 29 5.0 4N56-A nrPDB 28 7.0 3FNR-A nrPDB 28 7.9 5LWF-A nrPDB 28 8.1 3ZIU-A nrPDB 28 8.2 2CV2-A nrPDB 27 9.7 >5EKD-A nrPDB Length = 343 Score = 433 bits (1113), Expect = e-122, Method: Composition-based stats. Identities = 343/343 (100%), Positives = 343/343 (100%) Query: 18 ALHKGSAAAPALQKDSKKRVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSVLYSIVDLH 77 ALHKGSAAAPALQKDSKKRVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSVLYSIVDLH Sbjct: 1 ALHKGSAAAPALQKDSKKRVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSVLYSIVDLH 60 Query: 78 SITVPQDPAVLRQSILDMTAVLLACGINPEKSILFQQSQVSEHTQLSWILSCMVRLPRLQ 137 SITVPQDPAVLRQSILDMTAVLLACGINPEKSILFQQSQVSEHTQLSWILSCMVRLPRLQ Sbjct: 61 SITVPQDPAVLRQSILDMTAVLLACGINPEKSILFQQSQVSEHTQLSWILSCMVRLPRLQ 120 Query: 138 HLHQWKAKTTKQKHDGTVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQDLAQGFN 197 HLHQWKAKTTKQKHDGTVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQDLAQGFN Sbjct: 121 HLHQWKAKTTKQKHDGTVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQDLAQGFN 180 Query: 198 KKYGEFFPVPESILTSMKKVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKAVTD 257 KKYGEFFPVPESILTSMKKVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKAVTD Sbjct: 181 KKYGEFFPVPESILTSMKKVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKAVTD 240 Query: 258 FTSEVTYDPAGRAGVSNIVAVHAAVTGLSVEEVVRRSAGMNTARYKLAVADAVIEKFAPI 317 FTSEVTYDPAGRAGVSNIVAVHAAVTGLSVEEVVRRSAGMNTARYKLAVADAVIEKFAPI Sbjct: 241 FTSEVTYDPAGRAGVSNIVAVHAAVTGLSVEEVVRRSAGMNTARYKLAVADAVIEKFAPI 300 Query: 318 KREIEKLKLDKDHLEKVLQIGSAKAKELAYTVCQEVKKLVGFL 360 KREIEKLKLDKDHLEKVLQIGSAKAKELAYTVCQEVKKLVGFL Sbjct: 301 KREIEKLKLDKDHLEKVLQIGSAKAKELAYTVCQEVKKLVGFL 343 >6DFU-A nrPDB Length = 337 Score = 424 bits (1089), Expect = e-119, Method: Composition-based stats. Identities = 137/331 (41%), Positives = 209/331 (63%), Gaps = 4/331 (1%) Query: 33 SKKRVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSVLYSIVDLHSITVPQDPAVLRQSI 92 +K VFSG+QP+G L +GNYLGA+ +WV++Q++Y ++ +VDLH+ITV QDP LR++ Sbjct: 5 AKPIVFSGVQPSGELTIGNYLGALRNWVKMQEDY-ECIFCVVDLHAITVRQDPVALRKAT 63 Query: 93 LDMTAVLLACGINPEKSILFQQSQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHD 152 LD+ A+ LACGI+P KS +F QS V EHTQLSW+L+C + + Q+K K+ + + Sbjct: 64 LDVLALYLACGIDPNKSTIFVQSHVPEHTQLSWVLNCYTYFGEMSRMTQFKDKSARYAEN 123 Query: 153 GTVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQDLAQGFNKKYGEFFPVPESIL- 211 VGL YPVL AADILLY++ VPVG+DQ QH+E+ +D+A FN YG F +PE + Sbjct: 124 INVGLFDYPVLMAADILLYQAKSVPVGDDQKQHLEITRDIANRFNALYGNIFTIPEIFIG 183 Query: 212 TSMKKVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKAVTDFTSE--VTYDPAGR 269 + ++ SL+DP KMSKSD ++ V + + P+ + +K ++AVTD V YD + Sbjct: 184 KAGARIMSLQDPEKKMSKSDDNRNNVVTLLEDPKSVAKKIKRAVTDSDEPPVVRYDVQNK 243 Query: 270 AGVSNIVAVHAAVTGLSVEEVVRRSAGMNTARYKLAVADAVIEKFAPIKREIEKLKLDKD 329 AGVSN++ + +AVT + ++ + G K AVAD V A ++ + + D+ Sbjct: 244 AGVSNLLDILSAVTDKPIADLEKEFEGKMYGHLKTAVADEVSTLLASLQERFHQYRNDET 303 Query: 330 HLEKVLQIGSAKAKELAYTVCQEVKKLVGFL 360 L+ +L+ G+ KA+ A +V + VGF+ Sbjct: 304 LLDNILRQGAEKARAKAQETLAKVYEAVGFV 334 >5DK4-A nrPDB Length = 329 Score = 422 bits (1084), Expect = e-118, Method: Composition-based stats. Identities = 136/326 (41%), Positives = 211/326 (64%), Gaps = 4/326 (1%) Query: 35 KRVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSVLYSIVDLHSITVPQDPAVLRQSILD 94 K +FSGIQP+G++ +GNY+GA+ +V LQ EY+ + IVD H+ITV QDP LRQ+I Sbjct: 3 KTIFSGIQPSGVITIGNYIGALRQFVELQHEYN-CYFCIVDQHAITVWQDPHELRQNIRR 61 Query: 95 MTAVLLACGINPEKSILFQQSQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHDGT 154 + A+ LA GI+P ++ LF QS+V H Q +W+L C+V + L+ + Q+K K+ K + Sbjct: 62 LAALYLAVGIDPTQATLFIQSEVPAHAQAAWMLQCIVYIGELERMTQFKEKSA-GKEAVS 120 Query: 155 VGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQDLAQGFNKKYGEFFPVPESILTSM 214 GLLTYP L AADILLY + VPVGEDQ QH+EL +DLA+ FNK+YGE F +PE+ + + Sbjct: 121 AGLLTYPPLMAADILLYNTDIVPVGEDQKQHIELTRDLAERFNKRYGELFTIPEARIPKV 180 Query: 215 -KKVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKAVTDFTSEVTYDPAGRAGVS 273 ++ SL DP+ KMSKSDP+ A + + D + I +K + AVTD + YD + G+S Sbjct: 181 GARIMSLVDPTKKMSKSDPNPKAYITLLDDAKTIEKKIKSAVTDSEGTIRYDKEAKPGIS 240 Query: 274 NIVAVHAAVTGLSVEEVVRRSAGMNTARYKLAVADAVIEKFAPIKREIEKLKLDKDHLEK 333 N++ +++ ++G S+EE+ R+ G +K +A VIE PI+ ++ + L++ Sbjct: 241 NLLNIYSTLSGQSIEELERQYEGKGYGVFKADLAQVVIETLRPIQERYHHW-MESEELDR 299 Query: 334 VLQIGSAKAKELAYTVCQEVKKLVGF 359 VL G+ KA +A + +++++ +G Sbjct: 300 VLDEGAEKANRVASEMVRKMEQAMGL 325 >5V0I-A nrPDB Length = 337 Score = 421 bits (1083), Expect = e-118, Method: Composition-based stats. Identities = 142/331 (42%), Positives = 205/331 (61%), Gaps = 4/331 (1%) Query: 33 SKKRVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSVLYSIVDLHSITVPQDPAVLRQSI 92 +K VFSG QP+G L +GNY+GA+ WV +QD+Y +Y IVD H+ITV QD LR++ Sbjct: 5 TKPIVFSGAQPSGELTIGNYMGALRQWVNMQDDYH-CIYCIVDQHAITVRQDAQKLRKAT 63 Query: 93 LDMTAVLLACGINPEKSILFQQSQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHD 152 LD A+ LACGI+PEKS +F QS V EH QL W L+C L + Q+K K+ + + Sbjct: 64 LDTLALYLACGIDPEKSTIFVQSHVPEHAQLGWALNCYTYFGELSRMTQFKDKSARYAEN 123 Query: 153 GTVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQDLAQGFNKKYGEFFPVPESILT 212 GL YPVL AADILLY++ VPVGEDQ QH+EL +D+AQ FN YG+ F VPE + Sbjct: 124 INAGLFDYPVLMAADILLYQTNLVPVGEDQKQHLELSRDIAQRFNALYGDIFKVPEPFIP 183 Query: 213 -SMKKVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKAVTDFTSE--VTYDPAGR 269 S +V SL +P+ KMSKSD ++ + + + P+ +V+K ++AVTD V YD + Sbjct: 184 KSGARVMSLLEPTKKMSKSDDNRNNVIGLLEDPKSVVKKIKRAVTDSDEPPVVRYDVQNK 243 Query: 270 AGVSNIVAVHAAVTGLSVEEVVRRSAGMNTARYKLAVADAVIEKFAPIKREIEKLKLDKD 329 AGVSN++ + +AVTG S+ E+ ++ G K VADAV ++ + + D+ Sbjct: 244 AGVSNLLDILSAVTGQSIPELEKQFEGKMYGHLKGEVADAVSGMLTELQERYHRFRNDEA 303 Query: 330 HLEKVLQIGSAKAKELAYTVCQEVKKLVGFL 360 L++V++ G+ KA A + V + +GF+ Sbjct: 304 FLQQVMKDGAEKASAHASRTLKAVYEAIGFV 334 >3N9I-A nrPDB Length = 346 Score = 418 bits (1073), Expect = e-117, Method: Composition-based stats. Identities = 143/331 (43%), Positives = 210/331 (63%), Gaps = 4/331 (1%) Query: 33 SKKRVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSVLYSIVDLHSITVPQDPAVLRQSI 92 SK VFSG QP+G L +GNY+GA+ WV++QD+YD +Y IVDLH+IT QDPA+LR+ Sbjct: 14 SKPIVFSGAQPSGELTIGNYMGALRQWVQMQDDYD-CIYCIVDLHAITARQDPALLRKRT 72 Query: 93 LDMTAVLLACGINPEKSILFQQSQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHD 152 LD A+ LACGI+P+KS +F QS V EH+QLSW L+C L + Q+K K+ + + Sbjct: 73 LDTLALYLACGIDPKKSTIFVQSHVPEHSQLSWALNCYTYFGELSRMTQFKDKSARYAEN 132 Query: 153 GTVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQDLAQGFNKKYGEFFPVPESILT 212 GL YPVL AADILLY++ VPVGEDQ QH+EL +D+A FN YG+ F +PE + Sbjct: 133 INAGLFDYPVLMAADILLYQTNQVPVGEDQKQHLELSRDIASRFNNLYGDIFKIPEPFIP 192 Query: 213 S-MKKVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKAVTDFTSE--VTYDPAGR 269 +V SL+DP+ KMSKSD ++ + + + P+ +V+K ++A+TD + YD + Sbjct: 193 KAGARVMSLQDPTKKMSKSDDNRNNVIELLEDPKSVVKKIKRAMTDSDEPALIRYDVEKK 252 Query: 270 AGVSNIVAVHAAVTGLSVEEVVRRSAGMNTARYKLAVADAVIEKFAPIKREIEKLKLDKD 329 AGVSN++ + + VTG S+ E+ + G K AVADAV + ++ + D+ Sbjct: 253 AGVSNLLDILSGVTGQSIPELEAQFTGQMYGHLKGAVADAVSGMLSELQERYRTYREDEA 312 Query: 330 HLEKVLQIGSAKAKELAYTVCQEVKKLVGFL 360 L+ V++ G+AKA+ A +V + +GF+ Sbjct: 313 LLQDVMREGAAKARARAQVTLAKVYEAIGFV 343 >3PRH-A nrPDB Length = 388 Score = 399 bits (1025), Expect = e-111, Method: Composition-based stats. Identities = 127/327 (38%), Positives = 208/327 (63%), Gaps = 4/327 (1%) Query: 34 KKRVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSVLYSIVDLHSITVPQDPAVLRQSIL 93 K+ +FSGIQP+G + LGNY+GA++ +V LQ +Y+S + IVD H+ITVPQD LR++I Sbjct: 35 KQTIFSGIQPSGSVTLGNYIGAMKQFVELQHDYNS-YFCIVDQHAITVPQDRLELRKNIR 93 Query: 94 DMTAVLLACGINPEKSILFQQSQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHDG 153 ++ A+ LA G++PEK+ LF QS+V H Q W++ C+ + L+ + Q+K K+ K Sbjct: 94 NLAALYLAVGLDPEKATLFIQSEVPAHAQAGWMMQCVAYIGELERMTQFKDKS-KGNEAV 152 Query: 154 TVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQDLAQGFNKKYGEFFPVPESILTS 213 GLLTYP L AADILLY + VP GEDQ QH+EL ++LA+ FNKKY + F +PE + Sbjct: 153 VSGLLTYPPLMAADILLYGTDLVPPGEDQKQHLELTRNLAERFNKKYNDIFTIPEVKIPK 212 Query: 214 M-KKVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKAVTDFTSEVTYDPAGRAGV 272 + ++ SL DP KMSKSDP++ A + + D P+++ +K + AVTD V +D + GV Sbjct: 213 VGARIMSLNDPLKKMSKSDPNQKAYITLLDEPKQLEKKIKSAVTDSEGIVKFDKENKPGV 272 Query: 273 SNIVAVHAAVTGLSVEEVVRRSAGMNTARYKLAVADAVIEKFAPIKREIEKLKLDKDHLE 332 SN++ +++ + ++EE+ + G +K +A+ V+ PI+ +L ++ + L+ Sbjct: 273 SNLLTIYSILGNTTIEELEAKYEGKGYGEFKGDLAEVVVNALKPIQDRYYEL-IESEELD 331 Query: 333 KVLQIGSAKAKELAYTVCQEVKKLVGF 359 ++L G+ +A A + ++++ +G Sbjct: 332 RILDEGAERANRTANKMLKKMENAMGL 358 >3SZ3-A nrPDB Length = 341 Score = 390 bits (1001), Expect = e-109, Method: Composition-based stats. Identities = 134/335 (40%), Positives = 209/335 (62%), Gaps = 8/335 (2%) Query: 33 SKKRVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSVLYSIVDLHSITVPQDPAVLRQSI 92 SK V SG+QP+G L +GNYLGA+ W ++QD+YD Y +VDLH+ITV QDP L ++ Sbjct: 5 SKPIVLSGVQPSGELSIGNYLGALRQWQQMQDDYD-CQYCVVDLHAITVRQDPQALHEAT 63 Query: 93 LDMTAVLLACGINPEKSILFQQSQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHD 152 LD A+ LA G++P+KS LF QS V EH QL W+L+C ++ L + Q+K K+ + +D Sbjct: 64 LDALAICLAVGVDPKKSTLFVQSHVPEHAQLGWVLNCYTQMGELSRMTQFKDKSARYAND 123 Query: 153 GTVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQDLAQGFNKKY---GEFFPVPES 209 GL YPVL AADILLY + VPVG DQ QH+EL +D+A FN Y F +PE Sbjct: 124 VNAGLFGYPVLMAADILLYGAHQVPVGSDQKQHLELARDIATRFNNIYSPEQPIFTIPEP 183 Query: 210 ILTSMK-KVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKAVTDFTSE--VTYDP 266 + ++ +V SL+D + KMSKSD ++ + + + P+ I++K KA TD + + YD Sbjct: 184 YIPTVNARVMSLQDATKKMSKSDDNRKNVITLLEDPKSIIKKINKAQTDAETPPRIAYDV 243 Query: 267 AGRAGVSNIVAVHAAVTGLSVEEVVRRSAGM-NTARYKLAVADAVIEKFAPIKREIEKLK 325 +AG++N++ +++A TG + E+ + AG+ +K V +AV+ P++ E ++++ Sbjct: 244 ENKAGIANLMGLYSAATGKTFAEIEAQYAGVEMYGPFKKDVGEAVVAMLEPVQAEYQRIR 303 Query: 326 LDKDHLEKVLQIGSAKAKELAYTVCQEVKKLVGFL 360 D+++L V++ G+ KA A ++V VGF+ Sbjct: 304 NDREYLNSVMRDGAEKASAKALQTLKKVYAAVGFV 338 >3U1V-A nrPDB Length = 338 Score = 388 bits (997), Expect = e-108, Method: Composition-based stats. Identities = 120/326 (36%), Positives = 196/326 (60%), Gaps = 4/326 (1%) Query: 35 KRVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSVLYSIVDLHSITVPQDPAVLRQSILD 94 K +FS I PTG++ +G Y+GA+ +V LQ EY+ + I D +ITV QDP LRQ+I Sbjct: 2 KTIFSAICPTGVITIGRYIGALRQFVELQHEYN-CYFCIADQSAITVWQDPHELRQNIRR 60 Query: 95 MTAVLLACGINPEKSILFQQSQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHDGT 154 + A+ LA GI+P ++ LF S+V H Q +W+L C+V + L+ + +K + K + Sbjct: 61 LAALYLAVGIDPTQATLFIASEVPAHAQAAWMLQCIVYIGELERMTLFKE-LSAGKEAVS 119 Query: 155 VGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQDLAQGFNKKYGEFFPVPESILTSM 214 GLLT+P + AA ILLY + VPVGE Q EL +DLA+ FNK+YGE F +PE+ + + Sbjct: 120 AGLLTHPPIYAAMILLYNTDIVPVGEYGKQLYELTRDLAERFNKRYGELFTIPEARIPKV 179 Query: 215 -KKVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKAVTDFTSEVTYDPAGRAGVS 273 ++ SL DP+ M +SDP+ A + + D + I +K + AVTD + YD + G+S Sbjct: 180 GARIMSLVDPTKSMYQSDPNPKAYITLLDDAKTIEKKIKSAVTDSEGTIRYDKEAKPGIS 239 Query: 274 NIVAVHAAVTGLSVEEVVRRSAGMNTARYKLAVADAVIEKFAPIKREIEKLKLDKDHLEK 333 N++ +++ ++G S+EE+ R+ G +K +A VIE PI+ ++ + L++ Sbjct: 240 NLLNIYSTLSGQSIEELERQYEGKGYGVFKADLAQVVIETLRPIQERYHHW-MESEELDR 298 Query: 334 VLQIGSAKAKELAYTVCQEVKKLVGF 359 VL G+ KA +A + +++++ +G Sbjct: 299 VLDEGAEKANRVASEMVRKMEQAMGL 324 >2EL7-A nrPDB Length = 337 Score = 353 bits (905), Expect = 7e-98, Method: Composition-based stats. Identities = 129/331 (38%), Positives = 186/331 (56%), Gaps = 9/331 (2%) Query: 35 KRVFSGIQPTGILHLGNYLGAIESWVRLQDE-YDSVLYSIVDLHSITVP--QDPAVLRQS 91 KRV SGIQP+G +H+GNYLGAI+ WV + ++ + IVD H++T P DP+ L Q Sbjct: 2 KRVLSGIQPSGEIHIGNYLGAIKQWVAIGEKLGRDAFFCIVDYHALTNPLAYDPSTLAQR 61 Query: 92 ILDMTAVLLACGINPEKSILFQQSQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKH 151 + V +A G++PEK LF QS V EHT+LSW+ + + L L + Q+K K +KQ Sbjct: 62 TFEAALVNIAAGLDPEKVTLFVQSHVPEHTELSWVFTTLTPLGDLTRMTQFKDKASKQ-E 120 Query: 152 DGTVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQDLAQGFNKKYGEFFPVPESIL 211 GLL YPVLQAADIL+YK+ VPVGEDQVQH+EL +++A+ FN +GE FP P+++L Sbjct: 121 TVWSGLLMYPVLQAADILIYKADTVPVGEDQVQHIELTREIARRFNHLFGETFPEPQALL 180 Query: 212 TSMKKVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKAVTDFTSEVTYDPAG--R 269 D AKMSKS + T+ + + E I QK + D DP R Sbjct: 181 NPEAPRVPGIDGKAKMSKSLGN---TIGLLEPEESIWQKIQHLPDDPQRIRLSDPGDPER 237 Query: 270 AGVSNIVAVHAAVTGLSVEEVVRRSAGMNTARYKLAVADAVIEKFAPIKREIEKLKLDKD 329 + ++ A + + R AG+ T K + D ++E PI+ E LK D D Sbjct: 238 TILFTYLSYFAPKDLVEALKEEYRKAGVGTYVVKRILFDHLMEALRPIRERAEALKKDPD 297 Query: 330 HLEKVLQIGSAKAKELAYTVCQEVKKLVGFL 360 ++ L G+ +A+ +A +EV++ VG L Sbjct: 298 YVMDALLEGAKRARAVAQATMEEVREKVGLL 328 >2G36-A nrPDB Length = 340 Score = 349 bits (894), Expect = 1e-96, Method: Composition-based stats. Identities = 118/333 (35%), Positives = 185/333 (55%), Gaps = 15/333 (4%) Query: 36 RVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSVLYSIVDLHSITVPQDP-AVLRQSILD 94 R+ SG++PTG LH+G+ +GA+E+WV+LQ+E + Y + D H++T D + L++ D Sbjct: 14 RILSGMRPTGKLHIGHLVGALENWVKLQEEGNECFYFVADWHALTTHYDDVSKLKEYTRD 73 Query: 95 MTAVLLACGINPEKSILFQQSQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHD-- 152 + LACGI+PEKS++F QS V EH +L+ + S +V + RL+ + +K ++ + Sbjct: 74 LVRGFLACGIDPEKSVIFVQSGVKEHAELALLFSMIVSVSRLERVPTYKEIKSELNYKDL 133 Query: 153 GTVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQDLAQGFNKKYGEFFPVPESILT 212 T G L YPVLQAADIL+YK+ VPVGEDQV H+EL +++A+ FN Y E FP PE+IL+ Sbjct: 134 STAGFLIYPVLQAADILIYKAEGVPVGEDQVYHIELTREIARRFNYLYDEVFPEPEAILS 193 Query: 213 SMKKVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKAVTDFTSEVTYDPAGRAGV 272 + K+ KMSKS + + + S +E+ Q + +TD DP G Sbjct: 194 RVPKLPGT--DGRKMSKSYGN---IINLEISEKELEQTILRMMTDPARVRRSDP-GNPEN 247 Query: 273 SNIVAVHAAVTGLSVEEVVRRSAGMNTARYKLAVADAVI-----EKFAPIKREIEKLKLD 327 + H A +S EE G TA ++ K API K+ D Sbjct: 248 CPVWKYHQAFD-ISEEESKWVWEGCTTASIGCVDCKKLLLKNMKRKLAPIWENFRKIDED 306 Query: 328 KDHLEKVLQIGSAKAKELAYTVCQEVKKLVGFL 360 +++ V+ G+ KA+E+A +EV++ + + Sbjct: 307 PHYVDDVIMEGTKKAREVAAKTMEEVRRAMNLM 339 >6NCR-A nrPDB Length = 354 Score = 330 bits (847), Expect = 4e-91, Method: Composition-based stats. Identities = 103/338 (30%), Positives = 170/338 (50%), Gaps = 18/338 (5%) Query: 34 KKRVFSGIQPTGILHLGNYLGAIESWVRLQDEY-DSVLYSIVDLHSITVPQDPAVLRQ-- 90 KKRV +G +PTG LHLG+++G+I + ++LQ++ + I DLH++T + Q Sbjct: 11 KKRVLTGDRPTGKLHLGHWIGSIMNRLQLQNDSRYDCFFIIADLHTLTTKTRKEEILQID 70 Query: 91 -SILDMTAVLLACGINPEKSILFQQSQVSEHTQLSWILSCMVRLPRLQHLHQWKA---KT 146 I D+ A L+ GI+PEKS ++ QS + E +L+ I S + L + + K Sbjct: 71 NHIYDVLADWLSVGIDPEKSAIYLQSAIPEIYELNLIFSMLTPLNHIMGIPSIKEMARNA 130 Query: 147 TKQKHDGTVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQDLAQGFNKKYGEFFPV 206 + + + GL+ YPVLQ+ADILL K+ VPVG+D H+EL +D+A+ FN+ YGE FP Sbjct: 131 SLNEESLSHGLIGYPVLQSADILLAKAHLVPVGKDNEAHVELTRDIAKTFNRLYGEVFPE 190 Query: 207 PESILTSMKKVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKAVTDFTSEVTYDP 266 P+ + + + + KMSKS + + ++D + + +K RK TD P Sbjct: 191 PDILQGELTALV-GTNGQGKMSKSANN---AIYLSDDAKTVQEKIRKLYTDPNRIHATTP 246 Query: 267 AGRAGVSNIVAVHAAVTGLSVEEVV-----RRSAGMNTARYKLAVADAVIEKFAPIKREI 321 G N + ++ + EEV R + K +A+ + P + + Sbjct: 247 GRVEG--NPLFIYHDLFNPHKEEVEEFKTRYRQGCIRDVEVKARLAEEINLFLNPFREKR 304 Query: 322 EKLKLDKDHLEKVLQIGSAKAKELAYTVCQEVKKLVGF 359 +L LE+ LQ G+ K + +A +EV +G Sbjct: 305 SELVAQPKFLEEALQQGTEKMRTVARETMEEVHDHLGL 342 >3TZL-A nrPDB Length = 322 Score = 327 bits (838), Expect = 4e-90, Method: Composition-based stats. Identities = 107/326 (32%), Positives = 175/326 (53%), Gaps = 10/326 (3%) Query: 36 RVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSVLYSIVDLHSITVPQDPAVLRQSILDM 95 RV +G+QP+G LH+GNY GAI+ V Q++ ++ I + H++T QD L+Q+ L Sbjct: 5 RVLTGLQPSGDLHIGNYFGAIKQMVDAQEKSQMFMF-IANYHAMTSSQDGEKLKQNSLKA 63 Query: 96 TAVLLACGINPEKSILFQQSQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHDGTV 155 A L+ GI+P+KS+ + QS V E +L WILS + L+ H +K K K + Sbjct: 64 AAAFLSLGIDPQKSVFWLQSDVKEVMELYWILSQFTPMGLLERAHSYKDKVAKG-LSASH 122 Query: 156 GLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQDLAQGFNKKYGEFFPVPESILTSMK 215 GL +YPVL AADILL+ + VPVG+DQ+QH+E+ +D+A N ++GE F +PE+ + Sbjct: 123 GLFSYPVLMAADILLFDTRIVPVGKDQIQHVEIARDIALKVNNEWGEIFTLPEARVNEEV 182 Query: 216 KVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKAVTDFTSEVTYDPAG--RAGVS 273 V D AKMSKS + T+ I S + + ++ VTD T+ DP + Sbjct: 183 AVVVGTD-GAKMSKSYQN---TIDIFSSEKTLKKQISSIVTDSTALE--DPKDHENCNIF 236 Query: 274 NIVAVHAAVTGLSVEEVVRRSAGMNTARYKLAVADAVIEKFAPIKREIEKLKLDKDHLEK 333 I + +G ++ G +K+ + + V F + + +L HL++ Sbjct: 237 KIAKLFLDESGQKELQIRYEKGGEGYGHFKIYLNELVNAYFKEAREKYNELLEKPSHLKE 296 Query: 334 VLQIGSAKAKELAYTVCQEVKKLVGF 359 +L G+ KA+++A Q++ + +G Sbjct: 297 ILDFGATKARKIAQEKMQKIYEKIGL 322 >2YY5-A nrPDB Length = 348 Score = 324 bits (829), Expect = 5e-89, Method: Composition-based stats. Identities = 112/341 (32%), Positives = 181/341 (53%), Gaps = 19/341 (5%) Query: 35 KRVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSVLYSIVDLHSITVPQDPAVLRQSILD 94 KR +GIQ +G HLGNYLG ++S + LQ++ ++ + DLHSITV P L+Q+ D Sbjct: 5 KRALTGIQASGKQHLGNYLGVMQSLIELQEQCQLFVF-VADLHSITVDFQPQALKQNNFD 63 Query: 95 MTAVLLACGINPEKSILFQQSQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHDGT 154 + LLA G++P+K+ LF QS + EH+ + +++ L LQ + Q+KAK +Q + Sbjct: 64 LVRTLLAVGLDPQKACLFLQSDLLEHSMMGYLMMVQSNLGELQRMTQFKAKKAEQTRNPN 123 Query: 155 ------VGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQDLAQGFNKKYGEFFPVPE 208 GLLTYP L A DILLY+ VPVG DQ QH+EL +DLAQ KK+ +P+ Sbjct: 124 GTLNIPTGLLTYPALMAGDILLYQPDIVPVGNDQKQHLELTRDLAQRIQKKFKLKLRLPQ 183 Query: 209 SILTS-MKKVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKAVTDFTSEVTYDPA 267 + ++ L DP+ KMSKS ++ + + D E +V+K R+A TD +++ + Sbjct: 184 FVQNKDTNRIMDLFDPTKKMSKSSKNQNGVIYLDDPKEVVVKKIRQATTDSFNKIRFASK 243 Query: 268 GRAGVSNIVAVHAAVTGLSVEEVVRRSAG---------MNTARYKLAVADAVIEKFAPIK 318 + GV+N++ + A+ V + + G + K A+ +A + I+ Sbjct: 244 TQPGVTNMLTILKALLKEPVNQSLTNQLGNDLEAYFSTKSYLDLKNALTEATVNLLVNIQ 303 Query: 319 REIEKLKLDKDHLEKVLQIGSAKAKELAYTVCQEVKKLVGF 359 R+ E++ ++ + LQ G +A+ A T G Sbjct: 304 RKREQI--SREQVFNCLQAGKNQAQATARTTLALFYDGFGL 342 >6MTK-A nrPDB Length = 329 Score = 313 bits (801), Expect = 8e-86, Method: Composition-based stats. Identities = 104/328 (31%), Positives = 172/328 (52%), Gaps = 12/328 (3%) Query: 36 RVFSGIQPTGILHLGNYLGAIESWVRLQDEY-DSVLYSIVDLHSITVPQDPAVLRQSILD 94 R+ +GIQ TG HLGN LGAI + L + + L+ I +LH++T +D A LRQ+ + Sbjct: 10 RILTGIQATGTPHLGNLLGAIIPAIELAKKPENDSLFFIANLHTLTQIKDAAQLRQNTYE 69 Query: 95 MTAVLLACGINPEKSILFQQSQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHDGT 154 + A LACG++ EK+I ++QS + E +L+W L C RL H +K K + D Sbjct: 70 IAAAWLACGLDTEKTIFYRQSDIPETCELTWYLDCFFPFQRLTLAHSFKDKADRL-QDVN 128 Query: 155 VGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQDLAQGFNKKYGEFFPVPESILTSM 214 GL YP+L AADILLY + VPVG+DQ+QH+E+ +D+A+ FN++ GE F +P + + Sbjct: 129 AGLFNYPILMAADILLYDAEVVPVGKDQLQHLEITRDVAEKFNRQMGEVFVLPGAEIQES 188 Query: 215 KKVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKAVTDFTSEVTYDPAGRAGVSN 274 K D KMSKS + + I +E+ ++ +D S +P Sbjct: 189 TKYVPGTD-GHKMSKSRGN---IINIFLPEKELKKQIMSIESDSKSLE--EPKD-PETDK 241 Query: 275 IVAVHAAVTGLSVEEVVRR---SAGMNTARYKLAVADAVIEKFAPIKREIEKLKLDKDHL 331 ++A + E +R+ + K + + ++E+FA + + + L Sbjct: 242 TFIIYALIATPEQTEALRQKYLAGNFGYGHAKTELLNLILERFAKERELFSYYMSNLNEL 301 Query: 332 EKVLQIGSAKAKELAYTVCQEVKKLVGF 359 E+ LQ G+ KA+ +A + +K++G+ Sbjct: 302 EEKLQQGAEKARVIARATLDKTRKVLGY 329 >1YID-B nrPDB Length = 351 Score = 308 bits (788), Expect = 3e-84, Method: Composition-based stats. Identities = 90/329 (27%), Positives = 162/329 (49%), Gaps = 11/329 (3%) Query: 37 VFSGIQPTGILHLGNYLGAIESWVRLQDEYDSVLYSIVDLHSITVPQD-PAVLRQSILDM 95 V +G +PTG LHLG+ G++++ VRLQDE + + D+ ++T D P +R+++L + Sbjct: 25 VLTGDRPTGALHLGHLAGSLQNRVRLQDEA-ELFVLLADVQALTDHFDRPEQVRENVLAV 83 Query: 96 TAVLLACGINPEKSILFQQSQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTTK--QKHDG 153 LA G++P+K+ QS V E +L+ +V + L+ KA+ + Sbjct: 84 ALDYLAAGLDPQKTTCVVQSAVPELAELTVYFLNLVTVSHLRQNPTVKAEIAQKGYGERV 143 Query: 154 TVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQDLAQGFNKKYGEFFPVPESILTS 213 G YPV QAADI + +T VPVG+DQ+ +E +++ + FN Y P++ L+ Sbjct: 144 PAGFFVYPVSQAADIAAFGATLVPVGDDQLPMLEQTREIVRRFNALYAPVLAEPQAQLSR 203 Query: 214 MKKVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKAVTDFTSEVTYDPAGRAGVS 273 + ++ L D AKMSKS + + + DS +E+ +K TD DP G Sbjct: 204 VPRLPGL-DGQAKMSKSLGN---AIALGDSADEVARKVMGMYTDPGHLRASDPGRVEGNP 259 Query: 274 NIVAVHAAVTGLSVEEVV---RRSAGMNTARYKLAVADAVIEKFAPIKREIEKLKLDKDH 330 + A + + + R+ G+ + K + D + API+ + + D D Sbjct: 260 VFTFLDAFDPDPARVQALKDQYRAGGLGDVKVKKHLIDVLNGVLAPIRTRRAEYERDPDA 319 Query: 331 LEKVLQIGSAKAKELAYTVCQEVKKLVGF 359 + + + G+A+ +E+A +V++ + Sbjct: 320 VLRFVTEGTARGREVAAQTLGQVRRAMRL 348 >5TEW-A nrPDB Length = 344 Score = 298 bits (764), Expect = 2e-81, Method: Composition-based stats. Identities = 98/338 (28%), Positives = 169/338 (50%), Gaps = 18/338 (5%) Query: 33 SKKRVFSGIQPTGILHLGNYLGAIESWVRLQDEYD-SVLYSIVDLHSITVPQDPAVLRQS 91 SKKRV +G+ TG HLGNY+GAI VR D + D H I + ++ QS Sbjct: 10 SKKRVLTGVTTTGTPHLGNYVGAIRPAVRAAQNPDTESFLFLADYHGIIKCHEQEMIHQS 69 Query: 92 ILDMTAVLLACGINPEKSILFQQSQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKH 151 + A LACG++PE++ ++QS + E +L+WIL+C+ + H +KA Sbjct: 70 TQAVAATWLACGLDPERTTFYRQSDIPEVMELNWILTCITAKGLMNRAHAYKAAVQANAE 129 Query: 152 DG--------TVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQDLAQGFNKKYGEF 203 +G +GL +YP+L ADIL++ + VPVG DQ+QH+E+ +D+A FN ++ E Sbjct: 130 NGQEDPDFGVEMGLFSYPILMTADILMFNANEVPVGRDQIQHVEMARDIAGRFNHRFQEL 189 Query: 204 FPVPESILTSMKKVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKAVTDFTSEVT 263 F +PE + ++ D KMSKS + T+ + ++ ++ + K +T+ Sbjct: 190 FTLPEVKIDENVELLVGLD-GRKMSKSYGN---TIPLWENDKKTQKSVNKIITNMKE--P 243 Query: 264 YDPAGRAGVSNIVAVHAAVTGLSV--EEVVRRSAGMNTARYKLAVADAVIEKFAPIKREI 321 +P + S + ++ A + S E + G+ K A + + A ++ Sbjct: 244 GEPK-QPDESPLFEIYKAFSTPSETAEFTQMLADGLAWGEAKKLSAAKINAELAELRERY 302 Query: 322 EKLKLDKDHLEKVLQIGSAKAKELAYTVCQEVKKLVGF 359 L + +E++LQ G+ KA++ A + +V+ VG Sbjct: 303 NALTSNPSQIEEILQAGAQKARKEARELLDKVRDAVGI 340 >3P0I-A nrPDB Length = 690 Score = 254 bits (648), Expect = 5e-68, Method: Composition-based stats. Identities = 65/357 (18%), Positives = 141/357 (39%), Gaps = 44/357 (12%) Query: 11 ERWSFIRALHKGSAAAPALQKDSKK----RVFSGIQPTGILHLGNYLGAIESWVRLQDEY 66 ER+ +R++ + L+ +K R + G +P+G +H+ + + + Sbjct: 13 ERYKLLRSVGEECIQESELRNLIEKKPLIRCYDGFEPSGRMHIAQGIFKAVNVNKCTAAG 72 Query: 67 DSVLYSIVDLHSITVPQ---DPAVLRQSILDMTAVLLACGINPEKSILFQQS-QVSEHTQ 122 ++ + D ++ + + +R + V A G++ +K + S +++ H Sbjct: 73 CEFVFWVADWFALMNDKVGGELEKIRIVGRYLIEVWKAAGMDMDKVLFLWSSEEITSHAD 132 Query: 123 LSWILSCMVRLPRLQHLHQWKAKTT---KQKHDGTVGLLTYPVLQAADILLYKSTHVPVG 179 W + ++ + R + + K T K + T + YP++Q DI K+ +G Sbjct: 133 TYWRM--VLDIGRQNTIARIKKCCTIMGKTEGTLTAAQVLYPLMQCCDIFFLKADICQLG 190 Query: 180 EDQVQHMELVQDLAQGFNKKYGEFFPVPESILTSMKKVKSLRDPSAKMSKSDPDKLATVR 239 DQ + L ++ +K + ++ S + L+ AKMSKSDPD + + Sbjct: 191 LDQRKVNMLAREYCDLIGRKL-------KPVILSHHMLAGLKQGQAKMSKSDPD--SAIF 241 Query: 240 ITDSPEEIVQKFRKAVTD----FTSEVTYD--PAGRAGVSNIVAVHAAV----------- 282 + D+ E++ +K R+A S +T D P + ++ V Sbjct: 242 MEDTEEDVARKIRQAYCPRVKQSASAITDDGAPVATDDRNPVLDYFQCVVYARPGAAATI 301 Query: 283 ---TGLSVEEVVRRS--AGMNTARYKLAVADAVIEKFAPIKREIEKLKLDKDHLEKV 334 T + E++ + ++ K + D V P+++ + + LE V Sbjct: 302 DGTTYATYEDLEQAFVSDEVSEDALKSCLIDEVNALLEPVRQHFASNEEAHELLEAV 358 Score = 40.5 bits (93), Expect = 0.001, Method: Composition-based stats. Identities = 42/298 (14%), Positives = 97/298 (32%), Gaps = 33/298 (11%) Query: 67 DSVLYSIVDLHSITVPQ--DPAVLRQSILDMT-AVLLACGINPEKSILFQQSQV-SEHTQ 122 +V + D ++ + + L + A+L A G+ P + +++V + Sbjct: 416 GTVTLVLPDWSAVASDEITGVEKDISAALQVNCALLKAYGL-PSSVKIVTENEVILGNCD 474 Query: 123 LSWILSCMVRLPRLQHLHQWKAKTTKQKHDGTVGLLTYPVLQAADILLYKSTHVPVGEDQ 182 W+ + + + G + +++ A L+ +HV + Sbjct: 475 DFWV----SVIGIARKNLLSHVEELYGGEVRNAGQVIAALMRVATALMLSVSHV-ISTSL 529 Query: 183 VQHMELVQDLAQGFNKKYGEFFPVPESILTSMKKVKSLRDPSAKMSKSDPDKLATVRITD 242 H+ A+ + K+ + E + ++ + P + + + D Sbjct: 530 DGHI---NAFAREYTKERIDCVQTLEGRIPALHR--PGAAP------AVLGADDVLYLDD 578 Query: 243 SPEEIVQKFRKAVTDFTSEVTYDPAGRAGVSNIVAVHAAVTGLSVEEVVRRSAGMNTARY 302 + +I +K +KA + +S + A LS+E ++ Sbjct: 579 NDMDIRRKIKKAYSAPNE------EANPVISVAQHLLAQHGALSIERGEANGGNVSYNTP 632 Query: 303 KLAVADAVIEKFAP--IKREIEKLKLDKDHLEKVLQIGSAKAK----ELAYTVCQEVK 354 + VAD P +K + +L LD+ + L G K A + + Sbjct: 633 EALVADCGSGALHPADLKAAVLQLLLDRSAQARALLNGELKKNMTVLRNAEKKMAKKR 690 >5NSF-B nrPDB Length = 318 Score = 206 bits (524), Expect = 1e-53, Method: Composition-based stats. Identities = 70/335 (20%), Positives = 135/335 (40%), Gaps = 54/335 (16%) Query: 11 ERWSFIRALHKGSAAAPALQ---KDSKKRVFSGIQPTGILHLGNYLGAIESWVRLQDEYD 67 + + I+ + L+ K +K G +P+G +HLG+YL I+ + LQ+ Sbjct: 14 DEFEMIKRNTSEIISEEELREVLKKDEKSAGIGFEPSGKIHLGHYL-QIKKMIDLQNAGF 72 Query: 68 SVLYSIVDLHSITVPQDPAVLRQSILDMT-AVLLACGINPEKSILFQQSQVSEHTQLSWI 126 ++ + DL + + + I D V A G+ + + + ++T + Sbjct: 73 DIIIWLADLGAYLNQKGELDEIRKIGDYNKKVFEAMGLKAKYVYGSEHNLDKDYTLNVYR 132 Query: 127 LSCMVRLPRLQHLHQWKAKTTKQKHDGTVGLLTYPVLQAADILLYKSTHVPV-GEDQVQH 185 L+ L R + + ++ + V + YP++Q + + Y V V G +Q + Sbjct: 133 LALKTTLKRARRSMEL---IAREDENPKVAEVIYPIMQ-VNAIHYNGVDVAVGGMEQRKI 188 Query: 186 MELVQDLAQGFNKKYGEFFPVPESILTSMKKVKSLRDPSAKMSKSDPDKLATVRITDSPE 245 L ++L +P+ ++ V + D KMS S + + + DSPE Sbjct: 189 HMLAREL-------------LPKKVVCIHNPVLTGLDGEGKMSSSKGNF---IAVDDSPE 232 Query: 246 EIVQKFRKAVTDFTSEVTYDPAGRAGVSNIVAV-----------------HAAVTGLSVE 288 EI K +KA Y PAG + I+ + +T S E Sbjct: 233 EIRAKIKKA---------YCPAGVVEGNPIMEIAKYFLEYPLTIKRPEKFGGDLTVNSYE 283 Query: 289 EVV--RRSAGMNTARYKLAVADAVIEKFAPIKREI 321 E+ ++ ++ R K AVA+ +I+ PI++ + Sbjct: 284 ELESLFKNKELHPMRLKNAVAEELIKILEPIRKRL 318 >2CYB-A nrPDB Length = 323 Score = 202 bits (514), Expect = 2e-52, Method: Composition-based stats. Identities = 64/338 (18%), Positives = 122/338 (36%), Gaps = 50/338 (14%) Query: 11 ERWSFIRALHKGSAAAPALQ----KDSKKRVFSGIQPTGILHLGNYLGAIESWVRLQDEY 66 E+ I + L+ K R + G +P+G +HLG+ + ++ + LQ+ Sbjct: 5 EKLRLITRNAEEVVTEEELRQLIETKEKPRAYVGYEPSGEIHLGHMM-TVQKLMDLQEAG 63 Query: 67 DSVLYSIVDLHSITVPQDPAVLRQSILDMTA-VLLACGINPEKSILFQQSQVSEHTQLSW 125 ++ + D+H+ + + D V +A G++ ++ S+ Sbjct: 64 FEIIVLLADIHAYLNEKGTFEEIAEVADYNKKVFIALGLDESRAKFVLGSEYQLSRDYVL 123 Query: 126 ILSCMVRLPRLQHLHQWKAKTTKQKHDGTVGLLTYPVLQAADILLYKSTHVPVGEDQVQH 185 + M R+ L + + +++K D V + YP++QA DI G DQ + Sbjct: 124 DVLKMARITTLNRARRSMDEVSRRKEDPMVSQMIYPLMQALDIAHLGVDLAVGGIDQRKI 183 Query: 186 MELVQDLAQGFNKKYGEFFPVPESILTSMKKVKSLRDPSAKMSKSDPDKLATVRITDSPE 245 L ++ S + + D KMS S + + + D PE Sbjct: 184 HMLARENLPRLGY---------SSPVCLHTPILVGLDGQ-KMSSSKGN---YISVRDPPE 230 Query: 246 EIVQKFRKAVTDFTSEVTYDPAGRAGVSNIVAV--------------------HAAVTGL 285 E+ +K RKA Y PAG + I+ + V Sbjct: 231 EVERKIRKA---------YCPAGVVEENPILDIAKYHILPRFGKIVVERDAKFGGDVEYA 281 Query: 286 SVEEV--VRRSAGMNTARYKLAVADAVIEKFAPIKREI 321 S EE+ +S ++ K+AVA + ++ + Sbjct: 282 SFEELAEDFKSGQLHPLDLKIAVAKYLNMLLEDARKRL 319 >2J5B-A nrPDB Length = 348 Score = 198 bits (504), Expect = 3e-51, Method: Composition-based stats. Identities = 60/332 (18%), Positives = 121/332 (36%), Gaps = 35/332 (10%) Query: 12 RWSFIRALHKGSAAAPALQKDSKK----RVFSGIQPTGILHLGNYLGAIESWVRLQDEYD 67 R + + ++ + L++ ++G +P+G +H+ L + + + + Sbjct: 14 RLTQLLSIAEECETLDRLKQLVDSGRIFTAYNGFEPSGRIHIAQALITVMNTNNMIECGG 73 Query: 68 SVLYSIVDLHS---ITVPQDPAVLRQSILDMTAVLLACGINPEKSILFQQSQVSEHTQLS 124 ++ I D + + + D +R+ V ACGIN + + S+ Sbjct: 74 QMIIYIADWFAKMNLKMNGDINKIRELGRYFIEVFKACGINLDGTRFIWASEF--IASNP 131 Query: 125 WILSCMVRLPRLQHLHQWKAKTTKQKHDG----TVGLLTYPVLQAADILLYKSTHVPVGE 180 + M+ + + + K + + YP +QAAD+ VP G Sbjct: 132 SYIERMLDIAEFSTISRVKRCCQIMGRNESDCLKASQIFYPCMQAADVF----ELVPEGI 187 Query: 181 DQVQ---HMELVQDLAQGFNKKYGEFFPVPESILTSMKKVKSLRDPSAKMSKSDPDKLAT 237 D Q V LA + G P+ S + SL P KMSKSDP Sbjct: 188 DICQLGIDQRKVNMLAIEYANDRGLKIPIS----LSHHMLMSLSGPKKKMSKSDPQ--GA 241 Query: 238 VRITDSPEEIVQKFRKAVTDFTSEVTYDPAGRAGVSN-IVAVHAAVT-----GLSVEEVV 291 + + D+ +E+ +K +A ++ T+D + ++ + +E + Sbjct: 242 IFMDDTEQEVSEKISRAYC---TDETFDNPIFEYIKYLLLRWFGTLNLCGKIYTDIESIQ 298 Query: 292 RRSAGMNTARYKLAVADAVIEKFAPIKREIEK 323 + MN K VA+ + ++ +K Sbjct: 299 EDFSSMNKRELKTDVANYINTIIDLVREHFKK 330 >3VGJ-A nrPDB Length = 373 Score = 191 bits (484), Expect = 5e-49, Method: Composition-based stats. Identities = 59/353 (16%), Positives = 124/353 (35%), Gaps = 54/353 (15%) Query: 16 IRALHKGSAAAPALQKD----SKKRVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSVLY 71 I ++ L+ K + G +P+G +H+ L +L + ++ Sbjct: 34 ILSISSECIQPDELRVKLLLKRKLICYDGFEPSGRMHIAQGLLKSIIVNKLTSNGCTFIF 93 Query: 72 SIVDLHSITVPQ---DPAVLRQSILDMTAVLLACGINPEKSILFQQSQV-----SEHTQL 123 I D + + D +++ V +CG+N E S+ +E+ L Sbjct: 94 WIADWFAHLNNKMSGDLKKIKKVGSYFIEVWKSCGMNMENVQFLWASEEINKKPNEYWSL 153 Query: 124 SWILSCMVRLPRLQHLHQWKAKTTKQKHDGTVGLLTYPVLQAADILLYKSTHVPVGEDQV 183 +S + R++ + ++ + + + YP +Q ADI +G DQ Sbjct: 154 VLDISRSFNINRMKRCLKIMGRS--EGEENYCSQILYPCMQCADIFFLNVDICQLGIDQR 211 Query: 184 QHMELVQDLAQGFNKKYGEFFPVPESILTSMKKVKSLRDPSAKMSKSDPDKLATVRITDS 243 + L ++ K + ++ S + L + KMSKSD + + + + DS Sbjct: 212 KVNMLAREYCDIKKIKK-------KPVILSHGMLPGLLEGQEKMSKSDEN--SAIFMDDS 262 Query: 244 PEEIVQKFRKAVTDFTSEVTYDPAGRAGVSNIVAVHAAVTGLSVEEV----VRRSAG--- 296 ++ +K +KA Y P + I A ++ S E ++ G Sbjct: 263 ESDVNRKIKKA---------YCPPNVIENNPIYAYAKSIIFPSYNEFNLVRKEKNGGDKT 313 Query: 297 ---------------MNTARYKLAVADAVIEKFAPIKREIEKLKLDKDHLEKV 334 ++ K VA + + P++ + K+ L ++ Sbjct: 314 YYTLQELEHDYVNGFIHPLDLKDNVAMYINKLLQPVRDHFQNNIEAKNLLNEI 366 >3JXE-A nrPDB Length = 392 Score = 178 bits (452), Expect = 3e-45, Method: Composition-based stats. Identities = 56/303 (18%), Positives = 117/303 (38%), Gaps = 38/303 (12%) Query: 37 VFSGIQPTGILHLGNYLGAIESWVRLQDEYDSVLY-SIVD------LHSITVPQDPAVLR 89 +++G P+G +H+G+ + + LQ+++ LY I D ++T Sbjct: 76 LYTGRGPSGPMHIGHIIPFFATK-WLQEKFGVNLYIQITDDEKFLFKENLTFDDTKRWAY 134 Query: 90 QSILDMTAVLLACGINPEKSILFQQSQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQ 149 +ILD+ A G +P+K+ +FQ S+ ++ +++ ++ + + + + ++ Sbjct: 135 DNILDII----AVGFDPDKTFIFQNSEFTKIYEMAIPIAKKINFSMAKAVFGFTEQS--- 187 Query: 150 KHDGTVGLLTYPVLQAADILL-YKSTHVPVGEDQVQHMELVQDLAQGFNKKYGEFFPVPE 208 +G++ +P +Q A K +P DQ + L +D A+ + Sbjct: 188 ----KIGMIFFPAIQIAPTFFERKRCLIPAAIDQDPYWRLQRDFAESLGYY--------K 235 Query: 209 SILTSMKKVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKAVTDFTSE---VTYD 265 + K V SL S KMS S P+ + +TDSPE++ +K K + Sbjct: 236 TAALHSKFVPSLTSLSGKMSASKPE--TAIYLTDSPEDVEKKVWKFTLTGGRPTLKEQRE 293 Query: 266 PAGRAGVSNIVAVHAAVTGLSVEEVVRRS-----AGMNTARYKLAVADAVIEKFAPIKRE 320 G + +++ R + K + + E +R Sbjct: 294 KGGEPEKCVVFKWLEIFFEEDDKKLKERYYACKNGELTCGECKRYLISKIQEFLKEHQRR 353 Query: 321 IEK 323 +K Sbjct: 354 RKK 356 >3A04-A nrPDB Length = 372 Score = 176 bits (447), Expect = 9e-45, Method: Composition-based stats. Identities = 69/313 (22%), Positives = 122/313 (38%), Gaps = 45/313 (14%) Query: 33 SKKRVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSVLYSIVDLHSITVP--QDPAVLRQ 90 + V +G P+G H G+ L ++ + LQ V +I D + V +R Sbjct: 69 ERVAVLTGFMPSGKFHFGHKL-TVDQLIYLQKNGFKVFVAIADAEAFAVRRIGREEAVRI 127 Query: 91 SILDMTAVLLACGINPEKSILFQQSQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQK 150 ++ + A ++A G++P+ + + Q+ P + + + K T + Sbjct: 128 AVEEYIANMIALGLDPKDTEFYFQTNRGT--------------PYFRLIQLFSGKVTAAE 173 Query: 151 HDGTVGLLT-----YPVLQAADILL--------YKSTHVPVGEDQVQHMELVQDLAQGFN 197 + G LT + QAADIL Y+ VPVG DQ H+ L +DLA Sbjct: 174 MEAIYGELTPAKMMASLTQAADILHVQLDEYGGYRHVVVPVGADQDPHLRLTRDLADRMA 233 Query: 198 KKYGEFFPVPESILTSMKKVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKAVT- 256 E ++ K++ D KMS S PD +T+ +TD PE K +A+T Sbjct: 234 GVVEL-----ERPASTYHKLQPGLD-GRKMSSSRPD--STIFLTDPPEVARNKLFRALTG 285 Query: 257 -DFTSEVTYDPAGRAGVSNI--VAVHAAVTGLSVEEVVR---RSAGMNTARYKLAVADAV 310 T+E G V ++ + ++ + + + R + K + + Sbjct: 286 GRATAEEQRRLGGVPEVCSVYHMDLYHLMPDDGEVKHIYTSCRLGKILCGECKQIAWEKL 345 Query: 311 IEKFAPIKREIEK 323 A + +EK Sbjct: 346 ERFLAEHQSRLEK 358 >2CYC-A nrPDB Length = 375 Score = 171 bits (432), Expect = 5e-43, Method: Composition-based stats. Identities = 84/344 (24%), Positives = 125/344 (36%), Gaps = 56/344 (16%) Query: 38 FSGIQPTGILHLGNYLGAIESWVRLQDEYDSVLYSIVDLHSITVPQ---DPAVLRQSILD 94 + G + +G +HLG L A Q + D HS + D V+++ L Sbjct: 37 YIGFEISGYIHLGTGLMAGAKIADFQKAGIKTRVFLADWHSWINDKLGGDLEVIQEVALK 96 Query: 95 MTAV-----LLACGINPEKSILFQQSQVSE---HTQLSWILSCMVRLPRLQHLHQWKAKT 146 V + G +P+K S++ E + Q +S V L R+ + Sbjct: 97 YFKVGMEKSIEVMGGDPKKVEFVLASEILEKGDYWQTVIDISKNVTLSRVMRSITIMGR- 155 Query: 147 TKQKHDGTVGLLTYPVLQAADILLYKSTHVPVGEDQVQ----HMELVQDLAQGFNKKYGE 202 + L YP++Q ADI T G DQ + +E+ Q L GE Sbjct: 156 -QMGEAIDFAKLIYPMMQVADIFYQGVTIAHAGMDQRKAHVIAIEVAQKLRYHPIVHEGE 214 Query: 203 FFPVPESILTSMKKVKSLRDP----------------SAKMSKSDPDKLATVRITDSPEE 246 + + + L++P KMSKS P + V I DSPEE Sbjct: 215 KL---KPVAVHHHLLLGLQEPPKWPIESEEEFKEIKAQMKMSKSKP--YSAVFIHDSPEE 269 Query: 247 IVQKFRKAVTDFTSEVTYDPAGRAGVSNIVA--------------VHAAVTGLSVEEVVR 292 I QK RKA EV Y+P V I+ VT + EE+ R Sbjct: 270 IRQKLRKAFC-PAREVRYNPV-LDWVEYIIFREEPTEFTVHRPAKFGGDVTYTTFEELKR 327 Query: 293 RS--AGMNTARYKLAVADAVIEKFAPIKREIEKLKLDKDHLEKV 334 ++ K AVA+ +I PI+R EK + + V Sbjct: 328 DFAEGKLHPLDLKNAVAEYLINLLEPIRRYFEKHPEPLELMRSV 371 >3FOC-A nrPDB Length = 451 Score = 144 bits (363), Expect = 6e-35, Method: Composition-based stats. Identities = 71/363 (19%), Positives = 126/363 (34%), Gaps = 93/363 (25%) Query: 37 VFSGIQPT-GILHLGNYLGAIESWVRLQDEYDS-VLYSIVD------LHSITVPQDPAVL 88 +++G P+ G LHLG+ L I + LQD + V+ I D S++ + + Sbjct: 94 IYTGRGPSSGALHLGHLLPFIFTKY-LQDAFKCYVVIQITDDEKFLRNRSLSYAEVDSYT 152 Query: 89 RQSILDMTAVLLACGINPEKSILFQQSQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTTK 148 R++I D+ ACG +P+K+ +F SQ + + SC+V R+ + Q +A + Sbjct: 153 RENIKDII----ACGFDPDKTFIFINSQYLS-LKNRYRFSCLVD--RMLPISQLRA-SFG 204 Query: 149 QKHDGTVGLLTYPVLQAA-------DILLYKSTHVPV----------------------- 178 +D VG +P Q D L + +PV Sbjct: 205 FSNDANVGYAAFPPKQMLPVYSTYFDGLPFTRVPLPVGTGNEDAADAVSTKKASKKTPKK 264 Query: 179 -----------------------------GEDQVQHMELVQDLAQGFNKKYGEFFPVPES 209 G +Q + L +DLA P++ Sbjct: 265 DAVLSPVHVVEELFPDSKRYQKAMCLIASGIEQDPYFRLARDLAPRMGH--------PKN 316 Query: 210 ILTSMKKVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRK-AVT---DFTSEVT-- 263 K + L+ KMS SDP+ + + +TD+P +I K + A + D E Sbjct: 317 AYLLGKFLPGLQGSGTKMSASDPN--SAIYLTDTPAQIKNKINRYAFSGGRDTEEEHRAF 374 Query: 264 -YDPAGRAGVSNIVAVHAAVTGLSVEEVVRRSAGMNTARYKLAVADAVIEKFAPIKREIE 322 D + V + L + ++ + T K + + + Sbjct: 375 GADLSVDVSVRYLEVFMKDDAELEKLKADYKTGKLLTGEVKATLIGILQGLIKEHAERRD 434 Query: 323 KLK 325 K+ Sbjct: 435 KVD 437 >2CYA-A nrPDB Length = 364 Score = 144 bits (362), Expect = 7e-35, Method: Composition-based stats. Identities = 66/339 (19%), Positives = 119/339 (35%), Gaps = 35/339 (10%) Query: 11 ERWSFIRALHKGSAAAPALQKD----SKKRVFSGIQPTGILHLGNYLGAIESWVRLQDEY 66 ER++ I L+ ++ + + G +P+G+ H+G +L + L + Sbjct: 8 ERFNRIARNTVEIVTEEELKGLLASGARIKGYIGYEPSGVAHIG-WLVWMYKVKDLVEAG 66 Query: 67 DSVLYSIVDLHSITVPQ---DPAVLRQSILDMTAVLLACGINPEKSILFQQSQVSEHTQ- 122 H+ + D ++R + + V+ A G+ E+ +++ Sbjct: 67 VDFSVLEATWHAYINDKLGGDMDLIRAAARIVRRVMEAAGVPVERVRFVDAEELASDKDY 126 Query: 123 --LSWILSCMVRLPRLQHLHQWKAKTTKQKHDGTVGLLTYPVLQAADILLYKSTHVPVGE 180 L ++ L R++ + ++ L YP++Q +DI G Sbjct: 127 WGLVIRVAKRASLARVRRALTIMGRRAEEAE-VDASKLIYPLMQVSDIFYMDLDIALGGM 185 Query: 181 DQVQHMELVQDLAQGFNKKYGEFFPVPESILTSMKKVKSLRDP-------SAKMSKSDPD 233 DQ + L +D+A+ +K P KMSKS P+ Sbjct: 186 DQRKAHMLARDVAEKLGRKKPVAIHTPIISSLQGPGRMEASQGEIDDVLAEVKMSKSKPE 245 Query: 234 KLATVRITDSPEEIVQKFRKAVTDFT--------SEVTYDPAGRAG----VSNIVAVHAA 281 V + DS ++I +K RKA Y R G V Sbjct: 246 --TAVFVVDSDDDIRRKIRKAYCPAKQVQGNPVLEIARYILFARDGFTLRVDRPAKYGGP 303 Query: 282 VTGLSVEEVVRRS--AGMNTARYKLAVADAVIEKFAPIK 318 V S EE+ R ++ K AVA+++IE PI+ Sbjct: 304 VEYTSYEELERDYTDGRLHPLDLKNAVAESLIEVVRPIR 342 >5UJI-A nrPDB Length = 388 Score = 129 bits (323), Expect = 2e-30, Method: Composition-based stats. Identities = 52/329 (15%), Positives = 118/329 (35%), Gaps = 51/329 (15%) Query: 28 ALQKDSKKRVFSGIQPTGI-LHLGNYLGAIESWVRLQDEYDS-VLYSIVD-----LHSIT 80 A + +++G P+ +H+G+ + I + LQD ++ ++ + D +T Sbjct: 53 AYENKKPFYLYTGRGPSSEAMHVGHLIPFIFTK-WLQDVFNVPLVIQMTDDEKYLWKDLT 111 Query: 81 VPQDPAVLRQSILDMTAVLLACGINPEKSILFQQSQV----SEHTQLSWILSCMVRLPRL 136 + Q + ++ D+ ACG + K+ +F S + + V ++ Sbjct: 112 LDQAYSYAVENAKDII----ACGFDINKTFIFSDLDYMGMSSGFYKNVVKIQKHVTFNQV 167 Query: 137 QHLHQWKAKTTKQKHDGTVGLLTYPVLQAADIL-------LYKS----THVPVGEDQVQH 185 + + + +G +++P +QAA +P DQ + Sbjct: 168 KGIFGFTD-------SDCIGKISFPAIQAAPSFSNSFPQIFRDRTDIQCLIPCAIDQDPY 220 Query: 186 MELVQDLAQGFNKKYGEFFPVPESILTSMKKVKSLRDPSAKMSKSDPDKLATVRITDSPE 245 + +D+A P+ L +L+ KMS SDP+ +++ +TD+ + Sbjct: 221 FRMTRDVAPRIGY--------PKPALLHSTFFPALQGAQTKMSASDPN--SSIFLTDTAK 270 Query: 246 EIVQKFRKAVTDFTSEVTYDP---AGRAGVSNIVAVHAAV--TGLSVEEVVRRS--AGMN 298 +I K K + + G V +E++ + M Sbjct: 271 QIKTKVNKHAFSGGRDTIEEHRQFGGNCDVDVSFMYLTFFLEDDDKLEQIRKDYTSGAML 330 Query: 299 TARYKLAVADAVIEKFAPIKREIEKLKLD 327 T K A+ + + A + +++ + Sbjct: 331 TGELKKALIEVLQPLIAEHQARRKEVTDE 359 >1R6T-A nrPDB Length = 477 Score = 127 bits (319), Expect = 7e-30, Method: Composition-based stats. Identities = 52/329 (15%), Positives = 117/329 (35%), Gaps = 51/329 (15%) Query: 28 ALQKDSKKRVFSGIQPTGI-LHLGNYLGAIESWVRLQDEYDS-VLYSIVD-----LHSIT 80 A + +++G P+ +H+G+ + I + LQD ++ ++ + D +T Sbjct: 149 AYENKKPFYLYTGRGPSSEAMHVGHLIPFIFTK-WLQDVFNVPLVIQMTDDEKYLWKDLT 207 Query: 81 VPQDPAVLRQSILDMTAVLLACGINPEKSILFQQSQV----SEHTQLSWILSCMVRLPRL 136 + Q ++ D+ ACG + K+ +F S + + V ++ Sbjct: 208 LDQAYGDAVENAKDII----ACGFDINKTFIFSDLDYMGMSSGFYKNVVKIQKHVTFNQV 263 Query: 137 QHLHQWKAKTTKQKHDGTVGLLTYPVLQAADIL-------LYKS----THVPVGEDQVQH 185 + + + +G +++P +QAA +P DQ + Sbjct: 264 KGIFGFTD-------SDCIGKISFPAIQAAPSFSNSFPQIFRDRTDIQCLIPCAIDQDPY 316 Query: 186 MELVQDLAQGFNKKYGEFFPVPESILTSMKKVKSLRDPSAKMSKSDPDKLATVRITDSPE 245 + +D+A P+ L +L+ KMS SDP+ +++ +TD+ + Sbjct: 317 FRMTRDVAPRIGY--------PKPALLHSTFFPALQGAQTKMSASDPN--SSIFLTDTAK 366 Query: 246 EIVQKFRKAVTDFTSEVTYDP---AGRAGVSNIVAVHAAV--TGLSVEEVVRRS--AGMN 298 +I K K + + G V +E++ + M Sbjct: 367 QIKTKVNKHAFSGGRDTIEEHRQFGGNCDVDVSFMYLTFFLEDDDKLEQIRKDYTSGAML 426 Query: 299 TARYKLAVADAVIEKFAPIKREIEKLKLD 327 T K A+ + + A + +++ + Sbjct: 427 TGELKKALIEVLQPLIAEHQARRKEVTDE 455 >3HV0-A nrPDB Length = 393 Score = 125 bits (314), Expect = 2e-29, Method: Composition-based stats. Identities = 55/335 (16%), Positives = 123/335 (36%), Gaps = 55/335 (16%) Query: 37 VFSGIQPTGI-LHLGNYLGAIESWVRLQDEYDS-VLYSIVD------LHSITVPQDPAVL 88 +++G P+ LH+G+ + + + LQD + ++ + D ++T+ + Sbjct: 77 LYTGRGPSSESLHVGHLVPFLFTKY-LQDTFKVPLVIQLTDDEKFIFKSNLTLEETHNYA 135 Query: 89 RQSILDMTAVLLACGINPEKSILFQQSQ-VSEHTQLSWILSCMVRLPRLQHLHQWKAKTT 147 +++ D+ ACG +PE + +F + ++E + + +++ + +K Sbjct: 136 YENMKDII----ACGFDPELTFIFTNLEYIAELYPDILRIEKKISCSQIKSIFGFKDSC- 190 Query: 148 KQKHDGTVGLLTYPVLQAADILLYK-----------STHVPVGEDQVQHMELVQDLAQGF 196 VG +P +QAA VP DQ + +V+D+A Sbjct: 191 ------NVGKFAFPAVQAAPAFSSSFPHIFGGRTDIHCLVPHAIDQDPYFRMVRDVAPRL 244 Query: 197 NKKYGEFFPVPESILTSMKKVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRK-AV 255 + + SL+ KMS S + +++ + D+ E I K K A Sbjct: 245 GYL--------KPSSIHSIFLPSLQGSQTKMSASVQN--SSIFVNDNEESIRNKIMKYAF 294 Query: 256 T--DFTSEVTYDPAGRAGVSNIVAVHAAV--TGLSVEEVVRRS--AGMNTARYKLAVADA 309 + T E V + +EE+ ++ M + K + Sbjct: 295 SGGQATEEEQRRLGANLDVDVSWQYLRFLMEDDEKLEEIGKKYSSGEMLSGEIKSILVQE 354 Query: 310 VIEKFAPIKREIEKLKLDKDHLEKVLQIGSAKAKE 344 +++ ++ E + + V+ + K++E Sbjct: 355 LVKLTKNHQKNREAIN------DDVIAKFTNKSRE 383 >3KT6-A nrPDB Length = 438 Score = 120 bits (301), Expect = 9e-28, Method: Composition-based stats. Identities = 50/328 (15%), Positives = 116/328 (35%), Gaps = 54/328 (16%) Query: 37 VFSGIQPTGI-LHLGNYLGAIESWVRLQDEYDS-VLYSIVD------LHSITVPQDPAVL 88 +++G P+ +HLG+ + + + LQ+ +D ++ + D H +T+ Sbjct: 105 LYTGRGPSSDSMHLGHMIPFVFTK-WLQEVFDVPLVIELTDDEKFLFKHKLTINDVKNFA 163 Query: 89 RQSILDMTAVLLACGINPEKSILF--QQSQVSEHTQLSWILSCMVRLPRLQHLHQWKAKT 146 R++ D+ A G +P+ + +F Q + +S + + + + Sbjct: 164 RENAKDII----AVGFDPKNTFIFSDLQYMGGAFYETVVRVSRQITGSTAKAVFGFND-- 217 Query: 147 TKQKHDGTVGLLTYPVLQAADILL-----------YKSTHVPVGEDQVQHMELVQDLAQG 195 +G + +Q A +P DQ + + +D+A Sbjct: 218 -----SDCIGKFHFASIQIATAFPSSFPNVLGLPDKTPCLIPCAIDQDPYFRVCRDVA-- 270 Query: 196 FNKKYGEFFPVPESILTSMKKVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKAV 255 + + L + +L+ + KMS SD + +TD+P++I +K K Sbjct: 271 ------DKLKYSKPALLHSRFFPALQGSTTKMSASDD--TTAIFMTDTPKQIQKKINK-Y 321 Query: 256 TDFTSEVTYDPAGRAGVSN-------IVAVHAAVTGLSVE-EVVRRSAGMNTARYKLAVA 307 +V+ D G + ++ E +S + + K Sbjct: 322 AFSGGQVSADLHRELGGNPDVDVAYQYLSFFKDDDVFLKECYDKYKSGELLSGEMKKLCI 381 Query: 308 DAVIEKFAPIKREIEKLKLDKDHLEKVL 335 + + E + ++ D++ L+K + Sbjct: 382 ETLQEFVKAFQERRAQV--DEETLDKFM 407 >3I05-A nrPDB Length = 395 Score = 115 bits (288), Expect = 3e-26, Method: Composition-based stats. Identities = 44/318 (13%), Positives = 100/318 (31%), Gaps = 40/318 (12%) Query: 37 VFSGIQPTGI-LHLGNYLGAIESWVRLQDEYDS-VLYSIVDLHSITVPQDP-AVLRQSIL 93 +++G P+ +H+G+ + + + LQD + ++ + D P + Sbjct: 81 LYTGRGPSSESMHMGHLIPFMFTK-WLQDSFRVPLVIQMTDDEKFYFRNIPMEQVEAMTT 139 Query: 94 DMTAVLLACGINPEKSILFQQSQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHDG 153 + ++A G +PE + +F+ + + + ++ R Q + + Sbjct: 140 ENIKDIIAMGFDPELTFIFRDFDY-----MGCMYRTVAKIERAFTASQVRG-CFGFAMED 193 Query: 154 TVGLLTYPVLQAADILLYKS------------THVPVGEDQVQHMELVQDLAQGFNKKYG 201 G +P +QAA +P DQ + L +D+A Sbjct: 194 NCGRWMFPAIQAAPSFSAAFPHIFPPSMGNVFCLIPQAIDQDPYFRLTRDIAPRLGYL-- 251 Query: 202 EFFPVPESILTSMKKVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRK-------A 254 + + K L P KMS S V +TD+ + + K K A Sbjct: 252 ------KPAVIHSKFFPGLSGPKGKMSSSSG---TAVLLTDTEKMVKDKINKHAFSGGGA 302 Query: 255 VTDFTSEVTYDPAGRAGVSNIVAVHAAVTGLSVEEVVRRSAGMNTARYKLAVADAVIEKF 314 + + + + L+ + + T K + + + Sbjct: 303 TKQEHFLLGANVEVDVPIQWLSFFLEDDEELARVKKEYMLGRIMTGEVKKLLINTITAIT 362 Query: 315 APIKREIEKLKLDKDHLE 332 + + + + + L Sbjct: 363 KTHQEKRKLVTDEDVQLF 380 >4J75-A nrPDB Length = 409 Score = 114 bits (285), Expect = 5e-26, Method: Composition-based stats. Identities = 48/325 (14%), Positives = 121/325 (37%), Gaps = 48/325 (14%) Query: 37 VFSGIQPTG-ILHLGNYLGAIESWVRLQDEYDS-VLYSIVDLHSITVPQDPAVLRQSIL- 93 +++G P+ +HLG+ + LQ+ ++ ++ + D Q+ ++ + L Sbjct: 82 IYTGRGPSSLSMHLGHLIPFYFCKY-LQEAFNVPLVIQLSDDEKYLFNQNYSLEYINTLT 140 Query: 94 -DMTAVLLACGINPEKSILFQQSQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHD 152 + +++ G+NPE + +F+ ++ + ++ ++ + + L+Q H Sbjct: 141 NENVKDIISVGLNPELTFIFKNTEYA-----GYLYPTVLSIHKKTTLNQSM-NVFGFNHS 194 Query: 153 GTVGLLTYPVLQAADILLYK---------STHVPVGEDQVQHMELVQDLAQGFNKKYGEF 203 +G ++YP Q A VP G DQ + L +D+A Sbjct: 195 DNIGKISYPSFQIAPCFSQCFPNFLGKNIPCLVPQGIDQDPYFRLSRDIAVK-------- 246 Query: 204 FPVPESILTSMKKVKSLR-------------DPSAKMSKSDPDKLATVRITDSPEEIVQK 250 + + ++ + L+ D + K + + + + +TD+PE+I K Sbjct: 247 MALHKPVVVHSVFMPGLQGVNSKMSSTKKKKDDNGKSNSTFDHNNSVIFLTDTPEQIKNK 306 Query: 251 FRK-AVTDFTSEVTYDPAGRAGVSNIVAV----HAAVTGLSVEEV--VRRSAGMNTARYK 303 K A + + + + ++ + + E+ + M + K Sbjct: 307 INKYAFSGGGTTIQEHREKGGNLDKDISYQYLRYLLEDDNKLNEIGEKYKKGEMLSGEIK 366 Query: 304 LAVADAVIEKFAPIKREIEKLKLDK 328 + D + E + + + L ++ Sbjct: 367 KILIDVLTELVLKHQEKKKSLTDEE 391 >2DLC-X nrPDB Length = 394 Score = 110 bits (275), Expect = 8e-25, Method: Composition-based stats. Identities = 66/342 (19%), Positives = 115/342 (33%), Gaps = 55/342 (16%) Query: 36 RVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSVLYSIVDLHSITVPQDPAVLRQSILD- 94 +++ G PTG H G ++ + V + DLH+ + + Sbjct: 41 KLYWGTAPTGRPHCGYFVP-MTKLADFLKAGCEVTVLLADLHAFLDNMKAPLEVVNYRAK 99 Query: 95 -----MTAVLLACGINPEKSILFQQSQV---SEHTQLSWILSCMVRLPRLQHLHQWKAKT 146 + A+L + + EK S ++T + LS +V + A Sbjct: 100 YYELTIKAILRSINVPIEKLKFVVGSSYQLTPDYTMDIFRLSNIVSQNDAKRAG---ADV 156 Query: 147 TKQKHDGTVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQD-LAQGFNKKYGEFFP 205 KQ + + L YP++QA D G DQ + L ++ L KK Sbjct: 157 VKQVANPLLSGLIYPLMQALDEQFLDVDCQFGGVDQRKIFVLAEENLPSLGYKKRAHL-- 214 Query: 206 VPESILTSMKKVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKAVTDFTSE---- 261 M + KMS SDP+ + + + P+++ +K A + Sbjct: 215 --------MNPMVPGLAQGGKMSASDPNSK--IDLLEEPKQVKKKINSAFCSPGNVEENG 264 Query: 262 ----VTYDPAGRAG-----------VSNIVAVHAAVTGLSVEEVV--RRSAGMNTARYKL 304 V Y A + +T S EE+ + ++ K+ Sbjct: 265 LLSFVQYVIAPIQELKFGTNHFEFFIDRPEKFGGPITYKSFEEMKLAFKEEKLSPPDLKI 324 Query: 305 AVADAVIEKFAPIKREIEKLKLDKDHLEKVLQIGSAKAKELA 346 VADA+ E PI++E +K+ Q S K +A Sbjct: 325 GVADAINELLEPIRQEFA---NNKEF-----QEASEKGYPVA 358 >3TZE-A nrPDB Length = 406 Score = 105 bits (262), Expect = 3e-23, Method: Composition-based stats. Identities = 51/310 (16%), Positives = 106/310 (34%), Gaps = 43/310 (13%) Query: 37 VFSGIQPTGI-LHLGNYLGAIESWVRLQDEYD-SVLYSIVD-----LHSITVPQDPAVLR 89 +++G P+ +H+G+ + + +QD + ++ I D S+ + A R Sbjct: 104 LYTGRGPSSKTMHIGHTIPFLLCKY-MQDAFKIRLVIQITDDEKFLWKSMRLEDAMAYGR 162 Query: 90 QSILDMTAVLLACGINPEKSILFQQSQVSEHTQLSWI-LSCMVRLPRLQHLHQWKAKTTK 148 ++I D+ G +P+ + +F + S H + + + +S + L + + Sbjct: 163 ENIKDIV----TLGFDPKLTYIFSNVEASHHFEENILKISKTINLNEAIKVFGF------ 212 Query: 149 QKHDGTVGLLTYPVLQAADILLYK--------STHVPVGEDQVQHMELVQDLAQGFNKKY 200 +G + +P + A VP DQ L +D A K Sbjct: 213 -DMSSNIGQVGFPAKEIAPCFSSSFRFIGKGAMCLVPAAVDQDPFFRLARDKA----KAL 267 Query: 201 GEFFPVPESILTSMKKVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKFRKAVTDFTS 260 GE P + + L+ + KMS SDP+ +++ + D+ + I +K A Sbjct: 268 GEKKPSSIYVSL----LPDLKGVNRKMSASDPN--SSIYLDDAQDTIRKKII-AYAYSGG 320 Query: 261 EVTY----DPAGRAGVSNIVAVHAAVTGLSVEEVVRRSAGMNTARYKLAVADAVIEKFAP 316 T + G V E RS + + + + Sbjct: 321 RKTLEEHREKGGDIDVDVPFEYLKYFLDDDQELEKYRSGYIKGEITSKEMKEKCVVVIQE 380 Query: 317 IKREIEKLKL 326 ++ + Sbjct: 381 FVSRYQESRK 390 >6BQZ-A nrPDB Length = 408 Score = 84.8 bits (208), Expect = 6e-17, Method: Composition-based stats. Identities = 54/323 (16%), Positives = 115/323 (35%), Gaps = 44/323 (13%) Query: 9 ARERWSFI-RALHKGSAAAPALQKDSKKRVF---SGIQPTGI-LHLGNYLGAIESWVRLQ 63 A E+ + I R H+ + L+K + R +G PT LHLG+ + I Q Sbjct: 11 AEEQLALIQRGTHEIISEEDLLKKLKENRPLKIKAGFDPTAPDLHLGHTV-LINKLKTFQ 69 Query: 64 DEYDSVLYSIVDLHSI------TVPQDPAVLRQSILDMTAVLLACG---INPEKSILFQQ 114 D V + I D ++ P + R+ + ++P K+ + Sbjct: 70 DLGHEVTFLIGDYTAMIGDPTGKSATRPPLSREQVEANAKTYQEQVFKILDPNKTKVRFN 129 Query: 115 SQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHDGTVG--LLTYPVLQAADILLYK 172 S+ + ++ + + + + T + + + YP++Q D + + Sbjct: 130 SEWFNQKSAADLIQ-LASQQTVSRMLERDDFTKRYNNHQPIAIHEFLYPLVQGYDSIALE 188 Query: 173 STHVPVGEDQVQHMELVQDLAQGFNKKYGEFFPVPESILTSMKKVKSLRDPSAKMSKSDP 232 + G DQ ++ + + L + + ES + + D KMSKS Sbjct: 189 ADVELGGTDQTFNLLMGRTLQSRYGQ---------ESQVCITVPILEGLDGVNKMSKSLG 239 Query: 233 DKLATVRITDSPEEIVQKFRKAVTDFTSEVTYDPAGRAGVSNIVAVHAAVTGLSVEEVVR 292 + + + D+P + QK + + + + ++ ++ Sbjct: 240 N---YIGVFDAPGAMYQKVLSMPDSL-------------IERYFDLLSFKSLDEIKALLD 283 Query: 293 R-SAGMNTARYKLAVADAVIEKF 314 +AG N K +A ++E+F Sbjct: 284 EIAAGRNPQEVKRILALELVERF 306 >4Q93-A nrPDB Length = 372 Score = 82.5 bits (202), Expect = 3e-16, Method: Composition-based stats. Identities = 63/345 (18%), Positives = 116/345 (33%), Gaps = 57/345 (16%) Query: 11 ERWSFIRALHKGSAAAPALQKDSKKR---VFSGIQPTGILHLGNYLGAIESWVRLQDEYD 67 E+ I + L++ K+R ++ G TG H+ ++ + Sbjct: 9 EKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHVAYFVP-MSKIADFLKAGC 67 Query: 68 SVLYSIVDLHSITV----PQDPAVLRQSILD--MTAVLLACGINPEKSILFQQSQV---S 118 V DLH+ P + LR S + + A+L + G+ EK + + Sbjct: 68 EVTILFADLHAYLDNMKAPWELLELRVSYYENVIKAMLESIGVPLEKLKFIKGTDYQLSK 127 Query: 119 EHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHDGTVGLLTYPVLQAADILLYKSTHVPV 178 E+T + LS +V + A+ KQ + L YP LQA D K Sbjct: 128 EYTLDVYRLSSVVTQHDSKKAG---AEVVKQVEHPLLSGLLYPGLQALDEEYLKVDAQFG 184 Query: 179 GEDQVQHMELVQDLAQGFNKKYGEFFPVPESILTSMKKVKSLRDPSAKMSKSDPDKLATV 238 G DQ + F +KY + + V L +KMS S+ + + Sbjct: 185 GIDQRKIF--------TFAEKYLPALGYSKRVHLMNPMVPGLT--GSKMSSSEEESK--I 232 Query: 239 RITDSPEEIVQKFRKAVTDFTSEVTYDPAGRAGVSNIVAV-------------------H 279 + D E++ +K +KA +P + + Sbjct: 233 DLLDRKEDVKKKLKKAFC--------EPGNVENNGVLSFIKHVLFPLKSEFVILRDEKWG 284 Query: 280 AAVTGLSVEEVVRRSAG--MNTARYKLAVADAVIEKFAPIKREIE 322 T + ++ + A ++ K +V A+ + PI+ + Sbjct: 285 GNKTYTAYVDLEKDFAAEVVHPGDLKNSVEVALNKLLDPIREKFN 329 >6BYQ-A nrPDB Length = 410 Score = 77.5 bits (189), Expect = 9e-15, Method: Composition-based stats. Identities = 51/307 (16%), Positives = 103/307 (33%), Gaps = 58/307 (18%) Query: 30 QKDSKKRVFSGIQPTGI-LHLGNYLGAIESWVRLQDEYDSVLYSIVDLHSI------TVP 82 + + + V +G PT LHLG+ + I+ LQ V + I D ++ Sbjct: 42 ETNERFIVKAGFDPTAPDLHLGHTV-LIQKLALLQQYGARVKFLIGDFTAMIGDPTGKNE 100 Query: 83 QDPAVLRQSILDMTAVLLACGINPEKSILFQQSQVSEHTQLSWILSCMVRLPRLQHLHQW 142 + R+ +L+ E+ + +E S L + ++ ++ Sbjct: 101 TRKPLNREQVLENAKTYE------EQIYKILDQKHTEVCFNSTWLDALGAKGMIELCAKF 154 Query: 143 K----------AKTTKQKHDGTVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQDL 192 AK K+ ++ YP+LQ D + + G DQ ++ + + L Sbjct: 155 SVARMLERDDFAKRHKENRPISIVEFLYPLLQGYDSVAMGADIELGGNDQKFNLLVGRFL 214 Query: 193 AQGFN-KKYGEFFPVPESILTSMKKVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQKF 251 + + K +P + D KMSKS + V IT+ P + K Sbjct: 215 QRAYGLNKEQSIITMP---------LLEGLDGVQKMSKSLGN---YVGITEEPNAMFGKI 262 Query: 252 RKAVTDFTSEVTYDPAGRAGVSNIVAVHAAVTGLSVEEVVRRSAG-----MNTARYKLAV 306 D + + ++ ++EE+ G ++ K + Sbjct: 263 MSVSDDL----------------MWRYYTLLSAKTLEEIEDLKHGILNQTLHPKAVKEDL 306 Query: 307 ADAVIEK 313 A ++ + Sbjct: 307 AGEIVAR 313 >1H3F-A nrPDB Length = 432 Score = 72.5 bits (176), Expect = 3e-13, Method: Composition-based stats. Identities = 47/266 (17%), Positives = 94/266 (35%), Gaps = 34/266 (12%) Query: 11 ERWSFIRALHKGSAAAPAL-QKDSKKRVFS---GIQPTGI-LHLGNYLGAIESWVRLQDE 65 E + ++ + L K + R + G PT LHLG+ + + + Q+ Sbjct: 10 EALALLKRGAEEIVPEEELLAKLKEGRPLTVKLGADPTRPDLHLGHAV-VLRKMRQFQEL 68 Query: 66 YDSVLYSIVDLHSIT------VPQDPAVLRQSILDMTAVLLA-----CGINPEKSILFQQ 114 V+ I D + P + + + +A P L Sbjct: 69 GHKVVLIIGDFTGMIGDPSGRSKTRPPLTLEETRENAKTYVAQAGKILRQEPHLFELRYN 128 Query: 115 SQVSE---HTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHDGTVGLLTYPVLQAADILLY 171 S+ E ++ + S M L+ +K K + ++ L YP QA D + Sbjct: 129 SEWLEGLTFKEVVRLTSLMTVAQMLER-EDFK-KRYEAGIPISLHELLYPFAQAYDSVAI 186 Query: 172 KSTHVPVGEDQVQHMELVQDLAQGFNKKYGEFFPVPESILTSMKKVKSLRDPSAKMSKSD 231 ++ G DQ ++ + +++ + + + F +P + D KMSKS Sbjct: 187 RADVEMGGTDQRFNLLVGREVQRAYGQSPQVCFLMP---------LLVGLDGREKMSKSL 237 Query: 232 PDKLATVRITDSPEEIVQKFRKAVTD 257 + + +T+ PE + +K + Sbjct: 238 DN---YIGLTEPPEAMFKKLMRVPDP 260 >3HZR-A nrPDB Length = 386 Score = 53.6 bits (127), Expect = 1e-07, Method: Composition-based stats. Identities = 38/265 (14%), Positives = 87/265 (32%), Gaps = 35/265 (13%) Query: 61 RLQDEYD-SVLYSIVDLHSITVPQ-DPAVLRQSILDMTAVLLACGINPEKSILFQQSQVS 118 LQD ++ V+ I+D + + + D+ +LA G N +K+ ++ Q Sbjct: 108 YLQDAFNIQVIIQILDDIKVLNREATINEASKMSNDLMKYILAFGFNEDKTFIYTDYQY- 166 Query: 119 EHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHDGTVGLLTYPVLQAADILLYK------ 172 ++ +S + + + + ++ +G L P + A + Sbjct: 167 -FGKMYRTISLVEKATAYNVVQPF----FNFEYSDNIGKLASPSIMTASMFSQSYSHFFS 221 Query: 173 ---STHVPVGEDQVQHMELVQDLAQGFNKKYGEFFPVPESILTSMKKVKSLRDPSAKMSK 229 V VQ ++ +A N F P + K+ L K Sbjct: 222 SPARCLVLDSIKNVQFHSIIDQIATTLN------FIQPTVLF---HKMVPLLSGVTKF-- 270 Query: 230 SDPDKLATVRITDSPEEIVQKFRKAVTDFTSEVTYDPAGRAGVSNI------VAVHAAVT 283 P ++ ++D+ +++ +K K T + G +I + + ++ Sbjct: 271 DIPSDHNSILLSDNAKQVERKINKLAFSGGRNTTEEHKKLGGQCDIDVSFQLLNIFSSDN 330 Query: 284 GLSVE-EVVRRSAGMNTARYKLAVA 307 + E + + K V+ Sbjct: 331 AQVKDVEEKYSKGELLSGELKKIVS 355 >2JA2-A nrPDB Length = 498 Score = 39.4 bits (90), Expect = 0.003, Method: Composition-based stats. Identities = 21/122 (17%), Positives = 45/122 (36%), Gaps = 11/122 (9%) Query: 43 PTGILHLGNYLGAIESWVRLQDEYDSVLYSIVDLHSITVPQDPAVLRQSILDMTAVLLAC 102 PTG H+G A+ +W + + ++ I D + +D ++LD L Sbjct: 15 PTGTPHVGLVRTALFNWAYARHTGGTFVFRIEDTDA---QRDSEESYLALLDALR-WLGL 70 Query: 103 GINPEKSIL-----FQQSQVSEHT--QLSWILSCMVRLPRLQHLHQWKAKTTKQKHDGTV 155 + + ++QSQ +E L+ +L+ + +A+ + + Sbjct: 71 DWDEGPEVGGPYGPYRQSQRAEIYRDVLARLLAAGEAYHAFSTPEEVEARHVAAGRNPKL 130 Query: 156 GL 157 G Sbjct: 131 GY 132 >3AKZ-B nrPDB Length = 487 Score = 35.5 bits (80), Expect = 0.035, Method: Composition-based stats. Identities = 19/86 (22%), Positives = 33/86 (38%), Gaps = 13/86 (15%) Query: 43 PTGILHLGNYLGAIESWVRLQDEYDSVLYSIVDLHSITVPQDPAVLRQSILDMTAVLLAC 102 PTG LH+G A+ +W+ + E + I D R+ + L C Sbjct: 33 PTGHLHVGGARTALFNWMFARKEGGKFILRIED------TDTERSSREYEQQILESLRWC 86 Query: 103 GIN----PE---KSILFQQSQVSEHT 121 G++ P+ ++QS+ E Sbjct: 87 GLDWDEGPDIGGDFGPYRQSERLEIY 112 >2CFO-A nrPDB Length = 492 Score = 35.5 bits (80), Expect = 0.038, Method: Composition-based stats. Identities = 30/135 (22%), Positives = 48/135 (35%), Gaps = 21/135 (15%) Query: 43 PTGILHLGNYLGAIESWVRLQDEYDSVLYSIVDLHSITVPQDPAVLR-QSILDMTAVLLA 101 PTG LH+G A+ +W+ + + I D D R + ++ L Sbjct: 10 PTGNLHIGTARTAVFNWLYARHRGGKFILRIED-------TDRERSRPEYTENILEGLQW 62 Query: 102 CGINPEKSILFQQSQVSEHTQ----------LSWILSCMVRLPRLQHLHQWKAKTTKQKH 151 G+ ++ F QS + + L++ C Q KAK ++ Sbjct: 63 LGLTWDEGPYF-QSDRLDLYRQAIQTLLDKGLAYYCYCTPEELEALRAEQ-KAKGQAPRY 120 Query: 152 DGTVGLLTYPVLQAA 166 D LT P QAA Sbjct: 121 DNRHRHLT-PEEQAA 134 >3AL0-C nrPDB Length = 592 Score = 35.1 bits (79), Expect = 0.044, Method: Composition-based stats. Identities = 19/86 (22%), Positives = 33/86 (38%), Gaps = 13/86 (15%) Query: 43 PTGILHLGNYLGAIESWVRLQDEYDSVLYSIVDLHSITVPQDPAVLRQSILDMTAVLLAC 102 PTG LH+G A+ +W+ + E + I D R+ + L C Sbjct: 138 PTGHLHVGGARTALFNWMFARKEGGKFILRIED------TDTERSSREYEQQILESLRWC 191 Query: 103 GIN----PE---KSILFQQSQVSEHT 121 G++ P+ ++QS+ E Sbjct: 192 GLDWDEGPDIGGDFGPYRQSERLEIY 217 >4GRI-A nrPDB Length = 512 Score = 34.0 bits (76), Expect = 0.11, Method: Composition-based stats. Identities = 19/114 (16%), Positives = 37/114 (32%), Gaps = 17/114 (14%) Query: 43 PTGILHLGNYLGAIESWVRLQDEYDSVLYSIVDLHSITVPQDPAVLRQSILDMTAVLLAC 102 PTG+ H+G A+ ++ + L I D T + ++ L + L Sbjct: 33 PTGLQHIGGIRTALFNYFFAKSCGGKFLLRIED----TDQSRYSPEAENDLYSSLKWLGI 88 Query: 103 GINPEKSIL-----FQQSQVSEHT--------QLSWILSCMVRLPRLQHLHQWK 143 + + + QSQ S + C RL+ + + + Sbjct: 89 SFDEGPVVGGDYAPYVQSQRSAIYKQYAKYLIESGHAYYCYCSPERLERIKKIQ 142 >6Q8C-A nrPDB Length = 877 Score = 33.6 bits (75), Expect = 0.13, Method: Composition-based stats. Identities = 23/171 (13%), Positives = 53/171 (30%), Gaps = 26/171 (15%) Query: 207 PESILTSMKKVKSLRDPSAKMSKSDPDKLATVRITDSPE-------EIVQKFRKAVTDFT 259 P S + + + + KMSKS + + D E + + F Sbjct: 616 PVSAVLKADGLPVVISGTEKMSKSKNNGV------DPQELINAYGADTARLFMMFAAPPE 669 Query: 260 SEVTYDPAGRAGVSNIVAVHAAVTGLSVEE--VVRRSAGMNTARYK--LAVADAVIEKFA 315 + + +G G + +++ V+ AG K + + A Sbjct: 670 QSLEWSDSGVEGAHRFLRRLWRTVYEYLKQGGAVKAFAGNQDGLSKELKDLRHKLHSTTA 729 Query: 316 PIKR---EIEKLKLDKDHLEKVLQI------GSAKAKELAYTVCQEVKKLV 357 + ++ + ++L GS + + +A V + +L+ Sbjct: 730 KVSDDYGRRQQFNTAIAAVMELLNQYDKTDTGSEQGRAVAQEVLEAAVRLL 780 >2C54-A nrPDB Length = 379 Score = 32.8 bits (73), Expect = 0.21, Method: Composition-based stats. Identities = 27/162 (16%), Positives = 60/162 (37%), Gaps = 25/162 (15%) Query: 48 HLGNYLGAI--ESWVRLQDEYDSVLYSIVDLHSITVPQDPAVLRQSILDMTAVLLACGIN 105 H G+Y+ A + + ++ + +VDL + + ++ A + G Sbjct: 51 HEGHYVIASDWKKNEHMTEDMFCDEFHLVDLRVMENCLKVTEGVDHVFNLAADMGGMG-- 108 Query: 106 PEKSILFQQSQVSEHTQLSWILS-CMVRLPRLQHLHQWKAKTTKQKHDGTVGLLTYP--- 161 F QS S + ++S M+ R+ + ++ ++ YP Sbjct: 109 ------FIQSNHSVIMYNNTMISFNMIEAARINGIKRFFYASSA---------CIYPEFK 153 Query: 162 VLQAADILLYKSTHVPVGEDQVQHME--LVQDLAQGFNKKYG 201 L+ ++ L +S P +E ++L + +NK +G Sbjct: 154 QLETTNVSLKESDAWPAEPQDAYGLERLATEELCKHYNKDFG 195 >5K0S-A nrPDB Length = 536 Score = 32.4 bits (72), Expect = 0.33, Method: Composition-based stats. Identities = 17/81 (20%), Positives = 29/81 (35%), Gaps = 5/81 (6%) Query: 21 KGSAAAPALQKDSKKRVFSGIQ-PTGILHLGNY--LGAIESWVRLQDEYDSVLYSI--VD 75 + P K + + I P G H+G+ L A ++ R Q +Y + D Sbjct: 13 EAQTQGPGSMSREKYYITTAIAYPNGKPHIGHAYELIATDAMARFQRLNGMDVYFLTGTD 72 Query: 76 LHSITVPQDPAVLRQSILDMT 96 H I + Q + D+ Sbjct: 73 EHGIKMLQSARKEGITPRDLA 93 >4G6Z-A nrPDB Length = 490 Score = 32.0 bits (71), Expect = 0.37, Method: Composition-based stats. Identities = 18/123 (14%), Positives = 42/123 (34%), Gaps = 32/123 (26%) Query: 43 PTGILHLGNYLGAIESWVRLQDEYDSVLYSIVDLHSITVPQDPAVLRQSILDMTAVLLAC 102 PTG +HLGN A+ W + + + I D ++++ + + Sbjct: 34 PTGFIHLGNIRSALYPWAFARKMKGTFVLRIED------TDVERSSQEAVDAILEGMAWL 87 Query: 103 GINPEKSILFQQSQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHDGTVGLLTYPV 162 G++ ++ +Q +Q + +++ + + G L YP Sbjct: 88 GLDYDEGPYYQ----------------------MQRMDRYREVLAQMQEKG----LVYPC 121 Query: 163 LQA 165 + Sbjct: 122 YMS 124 >2HZ7-A nrPDB Length = 851 Score = 32.0 bits (71), Expect = 0.39, Method: Composition-based stats. Identities = 16/85 (18%), Positives = 30/85 (35%), Gaps = 10/85 (11%) Query: 24 AAAPALQKDSKKRVFSGI--QPTGILHLGNYLGAIESWVRLQDEYDSVLYSIVDLHSITV 81 L+ RV + P+G HLG+ ++ + + + D Sbjct: 54 IIERDLEAGKYPRVVTRFPPDPSGYAHLGHVFASLLDFNTARQYGGQFNLRMDD------ 107 Query: 82 PQDPAVLRQSILDMTAVLLA-CGIN 105 +P + RQ +D A L G++ Sbjct: 108 -TNPELARQEYVDSIADDLKWLGLD 131 >6BRL-A nrPDB Length = 511 Score = 32.0 bits (71), Expect = 0.43, Method: Composition-based stats. Identities = 22/135 (16%), Positives = 41/135 (30%), Gaps = 13/135 (9%) Query: 33 SKKRVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSVLYSIVDLHSITVPQDPAVLRQSI 92 K RV PTG LHLG A+ ++ + + I D + S Sbjct: 10 EKVRVRFAPSPTGPLHLGGVRTALYDYLFAKHNGGDFILRIED------TDTQRYVPGSE 63 Query: 93 LDMTAVLLACGINPEKS-------ILFQQSQVSEHTQLSWILSCMVRLPRLQHLHQWKAK 145 + L G+ P++S ++QS+ + L + Sbjct: 64 EYIMEALEWIGMVPDESPKHGGPYAPYRQSERRDIYDRYTEQILKTDYAYLAFDTPEELD 123 Query: 146 TTKQKHDGTVGLLTY 160 + + + + Y Sbjct: 124 QIRAEFEARGDVFAY 138 >3AII-A nrPDB Length = 553 Score = 31.7 bits (70), Expect = 0.51, Method: Composition-based stats. Identities = 19/80 (23%), Positives = 33/80 (41%), Gaps = 10/80 (12%) Query: 43 PTGILHLGNYLGAIESWVRLQDEYDSVLYSIVDLHSITVPQDPAVLRQSILDMT-AVLLA 101 P+G LH+G+ AI + + ++ I D DP + DM A L Sbjct: 105 PSGPLHIGHARAAILNHEYARKYDGRLILRIED-------TDPRRVDPEAYDMIPADLEW 157 Query: 102 CGINPEKSILFQQSQVSEHT 121 G+ +++++ QS E Sbjct: 158 LGVEWDETVI--QSDRMETY 175 >5ZDO-A nrPDB Length = 548 Score = 31.7 bits (70), Expect = 0.54, Method: Composition-based stats. Identities = 16/86 (18%), Positives = 29/86 (33%), Gaps = 7/86 (8%) Query: 42 QPTGILHLGNYLGAIESWVRLQDEYDSVLYSIVDLHSITVPQDPAVLRQSILDMTAVLLA 101 +P G LH+G+ + ++ QD D T P+ ++ L Sbjct: 32 EPNGYLHIGHARSIVLNFGLAQDYGGECNLRFDD----TNPETEKEEYARAIEEDVRWL- 86 Query: 102 CGINPEKSILFQQSQVSEHTQLSWIL 127 G P + L+ Q + +L Sbjct: 87 -GFRPTRV-LYASDYFETMYQCALVL 110 >5H4V-A nrPDB Length = 488 Score = 31.7 bits (70), Expect = 0.60, Method: Composition-based stats. Identities = 14/63 (22%), Positives = 21/63 (33%), Gaps = 4/63 (6%) Query: 43 PTGILHLGNYLGAIESWVRLQDEYDSVLYSIVDLHSITVPQDPAVLRQSILDMTAVLLAC 102 PTG LH+G A+ W+ + + I D T Q + L Sbjct: 32 PTGYLHIGGARTALYCWLEARRRGGQFVLRIED----TDRQRSTQAAIDAILEAMQWLGL 87 Query: 103 GIN 105 G + Sbjct: 88 GYD 90 >3SP1-A nrPDB Length = 501 Score = 30.9 bits (68), Expect = 0.81, Method: Composition-based stats. Identities = 23/122 (18%), Positives = 42/122 (34%), Gaps = 19/122 (15%) Query: 128 SCMVRLPRLQHLHQWKAKTTKQKHDGTVGLLTYPVLQAADILLYKSTHVPVGEDQVQHM- 186 ++K + K G ++ + AA L Y + + V H+ Sbjct: 206 RNKTDFVLWFTNSKFKDQEMKWDSPWGFGYPSWHLECAAMNLEYFKDALDIHLGGVDHIG 265 Query: 187 -----ELVQDLAQGF-NKKYGEFFPVPESILTSMKKVKSLRDPSAKMSKSDPDKLATVRI 240 E+ +A+ F NKK+ + F E ++ KMSKS + + + Sbjct: 266 VHHINEIA--IAECFLNKKWCDVFVHGEFLIMDYN----------KMSKSRGNFITVKDL 313 Query: 241 TD 242 D Sbjct: 314 ED 315 >1IRX-A nrPDB Length = 523 Score = 30.5 bits (67), Expect = 1.1, Method: Composition-based stats. Identities = 29/205 (14%), Positives = 62/205 (30%), Gaps = 31/205 (15%) Query: 170 LYKSTHVPVGEDQVQHMELVQDLAQGFNKKYGEFFPV---PESILTSMKKVKSLRDPSAK 226 + P G+D H+ +A E E+ L+ M + ++ K Sbjct: 228 HFGVDFEPAGKD---HL-----VAGSSYDTGKEIIKEVYGKEAPLSLMYEFVGIKGQKGK 279 Query: 227 MSKSDPDKLATVRITDSPEEIVQKFRKAVTDFTSEVTYDPAGRAGVSNIVAVHAAVTGLS 286 MS S + + ++D E + + + + I+ ++ + Sbjct: 280 MSGSKGN---VILLSDLYEVLEPGLVRFI--YARHRPNKEIKIDLGLGILNLYDEFEKVE 334 Query: 287 V------------EEVVRRSAGMNTARYKLAVADAVIEKFAPIKREIEKLKLDKDHLEKV 334 EE+ R + + VA A A + + + D + V Sbjct: 335 RIYFGVEGGKGDDEELRRTYELSMPKKPERLVAQAPFRFLAVLVQLPHLTEED---IINV 391 Query: 335 LQIGSAKAKELAYTVCQEVKKLVGF 359 L ++L+ + VK + Sbjct: 392 LIKQGHIPRDLSKEDVERVKLRINL 416 >6B1P-A nrPDB Length = 471 Score = 30.5 bits (67), Expect = 1.1, Method: Composition-based stats. Identities = 16/112 (14%), Positives = 36/112 (32%), Gaps = 7/112 (6%) Query: 43 PTGILHLGNYLGAIESWVRLQDEYDSVLYSIVDLHSITVPQDPAVLRQSILDMTAVLLAC 102 PTG LH+G AI +++ + I D ++ + Sbjct: 20 PTGYLHIGGLRTAIFNYLFARANQGKFFLRIED------TDLSRNSIEAANAIIEAFKWV 73 Query: 103 GINPEKSILFQQSQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQKHDGT 154 G+ + IL+ QS+ E + ++ + + +++ Sbjct: 74 GLEYDGEILY-QSKRFEIYKEYIQKLLDEDKAYYCYMSKDELDALREEQKAR 124 >1YFI-A nrPDB Length = 262 Score = 30.5 bits (67), Expect = 1.2, Method: Composition-based stats. Identities = 23/172 (13%), Positives = 59/172 (34%), Gaps = 26/172 (15%) Query: 179 GEDQVQHME--LVQD-LAQGFNKKYGEFFPVPESILT-SMKKVKSLRDPSAKMSKSDP-D 233 G DQ+ H + + D L + + K + F ES+ + +D S+K+ K+ D Sbjct: 14 GIDQLPHTQHGVTSDRLGKLYEKYILDIFKDIESLKKYNTNAFPQEKDISSKLLKALNLD 73 Query: 234 KLATVRITDSPEEIVQKFRKAVTDFTSEVTYDPAGRAGVSNIVAV-HAAVTGLSVEEVVR 292 + ++ S ++ + + + + ++ + + H++ +S+ E Sbjct: 74 LDNIIDVSSSDTDLGRTIAGGSPKTDATIRFTFHNQSSRLVPLNIKHSSKKKVSIAEYDV 133 Query: 293 RS----AGMNTARYKLAVADA----------------VIEKFAPIKREIEKL 324 + G++ K + + E P + + Sbjct: 134 ETICTGVGISDGELKELIRKHQNDQSAKLFTPVQKQRLTELLEPYRERFIRW 185 >5IHX-A nrPDB Length = 395 Score = 29.7 bits (65), Expect = 2.0, Method: Composition-based stats. Identities = 15/59 (25%), Positives = 24/59 (40%), Gaps = 4/59 (6%) Query: 127 LSCMVRLPRLQHLHQWKAKTTKQKHDGTVGLLTYPVLQAAD--ILLYKSTHVPV-GEDQ 182 L +R+ + K + + + TYP++QA D +L V V G DQ Sbjct: 185 LGAYIRIGPMLGRDTVKNRMERGD-GMSFAEFTYPLMQAWDWWMLFKNGCQVQVGGSDQ 242 >4H3S-A nrPDB Length = 817 Score = 29.3 bits (64), Expect = 2.3, Method: Composition-based stats. Identities = 25/149 (16%), Positives = 45/149 (30%), Gaps = 20/149 (13%) Query: 16 IRALHKGSAAAPALQKDS------KKRVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSV 69 + + + A P L K+ K R +P G LH+G+ + ++ + + Sbjct: 227 LHKVGENPQAYPELMKEHLEVTGGKVRTRFPPEPNGYLHIGHSKAIMVNFGYAKYHNGTC 286 Query: 70 LYSIVDLHSITVPQDPAVLRQSILDMTAVLLACGINPEKSILFQQSQVSEHTQLSWIL-- 127 D T P+ A + L G P K + E +L+ +L Sbjct: 287 YLRFDD----TNPEKEAPEYFESIKRMVSWL--GFKPWKIT-YSSDYFDELYRLAEVLIK 339 Query: 128 -----SCMVRLPRLQHLHQWKAKTTKQKH 151 C ++ K T Sbjct: 340 NGKAYVCHCTAEEIKRGRGIKEDGTPGGE 368 >5TGT-A nrPDB Length = 502 Score = 29.3 bits (64), Expect = 2.4, Method: Composition-based stats. Identities = 8/58 (13%), Positives = 20/58 (34%), Gaps = 1/58 (1%) Query: 43 PTGILHLGNYLGAIESWVRLQDEYDSVLYSIVDLHSI-TVPQDPAVLRQSILDMTAVL 99 PTG H+G A+ + + + I D + + + + ++ + Sbjct: 20 PTGDPHVGTAYIALFNLCFARQHGGQFILRIEDTDQLRSTRESEQQIYDALRWLGIEW 77 >1QU3-A nrPDB Length = 917 Score = 29.0 bits (63), Expect = 3.3, Method: Composition-based stats. Identities = 11/44 (25%), Positives = 15/44 (34%), Gaps = 8/44 (18%) Query: 207 PESILTSMKKVKSLRDPSAKMSKSDPDKLATVRITDSPEEIVQK 250 P L S V KMSKS + + + + QK Sbjct: 578 PYKFLLSHGFVMDGE--GKKMSKSLGNVIV------PDQVVKQK 613 >3BYH-B nrPDB Length = 231 Score = 29.0 bits (63), Expect = 3.7, Method: Composition-based stats. Identities = 32/209 (15%), Positives = 73/209 (34%), Gaps = 23/209 (11%) Query: 10 RERWSFIRALHKGSAAAPALQKDSKKRVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSV 69 R W + L K S ++ + SK + + +E+ ++ + Sbjct: 32 RNGWILLEVLDKVSPSSVNWKHASKPPIKMPFR------------KVENCNQVIKIGKQL 79 Query: 70 LYSIVDLHSITVPQDPAVLRQSILDMTAVLLACGINPEKSILFQQSQVSEHTQLSWILSC 129 +S+V++ + Q L + + + + + +S++++ LSW Sbjct: 80 KFSLVNVAGNDIVQGNKKLI-----LGLLWQLMRFHMLQLLKSLRSEMTDADILSWANRK 134 Query: 130 MVRLPRLQHLHQWKAKTTKQKHDGTVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELV 189 + + R + +K K+ + GL +L A + + V GE + Sbjct: 135 VRTMGRKLQIESFKDKSL------SSGLFFLNLLWAVEPRVVNWNLVTKGETDDEKRLNA 188 Query: 190 QDLAQGFNKKYGEFFPVPESILTSMKKVK 218 + K F +PE I+ +K+ Sbjct: 189 TYIVSVARKLGCSVFLLPEDIVEVNQKMI 217 >2R70-A nrPDB Length = 852 Score = 28.6 bits (62), Expect = 4.0, Method: Composition-based stats. Identities = 13/63 (20%), Positives = 21/63 (33%), Gaps = 6/63 (9%) Query: 131 VRLPRLQHLHQWKAKTTKQKHD---GTVGLLTYPVLQAADILLYKSTHVPVGEDQVQHME 187 + + L K T + + +G + Q DI L P GED + Sbjct: 175 TYMGQANRLVAMKEVATGRNPNKDPLKLGYTFESIAQLLDITL---PVGPPGEDDKPWVP 231 Query: 188 LVQ 190 L + Sbjct: 232 LTR 234 >4ZO7-A nrPDB Length = 731 Score = 28.6 bits (62), Expect = 4.3, Method: Composition-based stats. Identities = 12/52 (23%), Positives = 24/52 (46%) Query: 189 VQDLAQGFNKKYGEFFPVPESILTSMKKVKSLRDPSAKMSKSDPDKLATVRI 240 V++LA+ + +FP E+ + + +PS K+S S P + + Sbjct: 512 VKELAESSDALLELWFPGTEAGRVTADLLSGASNPSGKLSMSFPQTTGQIPV 563 >6E8G-S nrPDB Length = 366 Score = 28.6 bits (62), Expect = 4.9, Method: Composition-based stats. Identities = 16/88 (18%), Positives = 31/88 (35%), Gaps = 5/88 (5%) Query: 82 PQDPAVLRQSILDMTAVLLACGINPEKSILFQQSQVSEHTQLSWI----LSCMVRLPRLQ 137 + L Q A LA G + E++ + + + E + + L C + L R Sbjct: 26 EKKKTELAQKARKEIADYLAAGKD-ERARIRVEHIIREDYLVEAMEILELYCDLLLARFG 84 Query: 138 HLHQWKAKTTKQKHDGTVGLLTYPVLQA 165 + K + + + P LQ+ Sbjct: 85 LIQSMKELDSGLAESVSTLIWAAPRLQS 112 >3FRR-A nrPDB Length = 191 Score = 28.6 bits (62), Expect = 5.0, Method: Composition-based stats. Identities = 22/120 (18%), Positives = 43/120 (35%), Gaps = 10/120 (8%) Query: 50 GNYLGAIESWVRLQDEYDSVLYSIVDLHSITVPQDPAVLRQSILDMTAVLLACGINPEKS 109 G+ LG+ RL+ V+ + + + L Q A LA G + E++ Sbjct: 1 GHMLGSGFKAERLRVNLRLVINRLK-----LLEKKKTELAQKARKEIADYLAAGKD-ERA 54 Query: 110 ILFQQSQVSEHTQLSWI----LSCMVRLPRLQHLHQWKAKTTKQKHDGTVGLLTYPVLQA 165 + + + E + + L C + L R + K + + + P LQ+ Sbjct: 55 RIRVEHIIREDYLVEAMEILELYCDLLLARFGLIQSMKELDSGLAESVSTLIWAAPRLQS 114 >4N56-A nrPDB Length = 553 Score = 27.8 bits (60), Expect = 7.0, Method: Composition-based stats. Identities = 27/199 (13%), Positives = 60/199 (30%), Gaps = 40/199 (20%) Query: 177 PVGEDQVQHMELVQDLAQGFNKKYGEFFPVPESILTSMKKVKSLRDPSAKMSKSDPDKLA 236 P+ E +Q+ EL + + + P + + + ++S SDP+ Sbjct: 248 PIVEKILQYRELTKLKSTYIDPLPDLIHPRTGRL---HTRFNQTATATGRLSSSDPNLQN 304 Query: 237 TVRITDSPEEIVQKFRKAVT----------DFTSEVTYDPAGRAGVSNIVAVHAAVTGLS 286 + + + Q+ R+A D++ A +G N++ V + Sbjct: 305 -IPVRTP---LGQRIRRAFIAEEGWLLVALDYSQIELRVLAHLSGDENLIRVFQEGRDIH 360 Query: 287 VEEVVRRSA-------------------GMNTARYKLAVADAVIEKFAP----IKREIEK 323 E G+ ++ + + I+R + Sbjct: 361 TETASWMFGVPREAVDPLMRRAAKTINFGVLYGMSAHRLSQELAIPYEEAQAFIERYFQS 420 Query: 324 LKLDKDHLEKVLQIGSAKA 342 + LEK L+ G + Sbjct: 421 FPKVRAWLEKTLEEGRRRG 439 >3FNR-A nrPDB Length = 464 Score = 27.8 bits (60), Expect = 7.9, Method: Composition-based stats. Identities = 8/20 (40%), Positives = 12/20 (60%) Query: 38 FSGIQPTGILHLGNYLGAIE 57 + PTG LH+G+ GA+ Sbjct: 36 YVSANPTGPLHIGHARGAVF 55 >5LWF-A nrPDB Length = 273 Score = 27.8 bits (60), Expect = 8.1, Method: Composition-based stats. Identities = 25/136 (18%), Positives = 50/136 (36%), Gaps = 10/136 (7%) Query: 180 EDQVQHMELVQDLAQGFNKKYGEFFPVPESILTSMKKVKSLRDPSAKMSKSDPDKLATVR 239 ED Q + +D +N P+ E + + +K L D S + S + L + Sbjct: 60 EDLNQRITYTRDDLVNYN-------PITEKHVDTGMTLKELADASLRYSDNAAQNLILKQ 112 Query: 240 ITDSPEEIVQKFRKAVTDFTSEVTYDPAGRAGVSNIVAVHAAVTGLSVEEVVRRSAGMNT 299 I PE + ++ RK + T+ ++P N T ++ +R A + Sbjct: 113 IG-GPESLKKELRKIGDEVTNPERFEPELNE--VNPGETQDTSTARALVTSLRAFALEDP 169 Query: 300 ARYKLAVADAVIEKFA 315 + + +I+ Sbjct: 170 GKLPSEKRELLIDWMK 185 >3ZIU-A nrPDB Length = 637 Score = 27.8 bits (60), Expect = 8.2, Method: Composition-based stats. Identities = 8/34 (23%), Positives = 12/34 (35%) Query: 203 FFPVPESILTSMKKVKSLRDPSAKMSKSDPDKLA 236 P E + + L KMSKS + + Sbjct: 387 IVPTKEPFQKLINQGMILGKDGQKMSKSLGNVVN 420 >2CV2-A nrPDB Length = 468 Score = 27.4 bits (59), Expect = 9.7, Method: Composition-based stats. Identities = 8/33 (24%), Positives = 14/33 (42%) Query: 43 PTGILHLGNYLGAIESWVRLQDEYDSVLYSIVD 75 PTG H+G A+ ++ + + I D Sbjct: 10 PTGDPHVGTAYIALFNYAWARRNGGRFIVRIED 42 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.309 0.126 0.310 Lambda K H 0.267 0.0389 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 11,552,289 Number of Sequences: 36641 Number of extensions: 408379 Number of successful extensions: 1890 Number of sequences better than 10.0: 79 Number of HSP's better than 10.0 without gapping: 79 Number of HSP's successfully gapped in prelim test: 46 Number of HSP's that attempted gapping in prelim test: 1598 Number of HSP's gapped (non-prelim): 136 length of query: 360 length of database: 10,336,785 effective HSP length: 98 effective length of query: 262 effective length of database: 6,745,967 effective search space: 1767443354 effective search space used: 1767443354 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.3 bits) S2: 59 (27.4 bits)