BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q9SUM3 (711 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 5GXU-A nrPDB 1335 0.0 6J79-A nrPDB 454 e-128 3ES9-A nrPDB 453 e-127 3QFR-A nrPDB 450 e-126 3FJO-A nrPDB 405 e-113 2BN4-A nrPDB 294 1e-79 1TLL-A nrPDB 248 5e-66 6EFV-A nrPDB 231 8e-61 1B1C-A nrPDB 127 1e-29 1BVY-F nrPDB 70 4e-12 4H2D-A nrPDB 67 4e-11 2B5O-A nrPDB 66 6e-11 3HR4-A nrPDB 63 3e-10 1YKG-A nrPDB 57 2e-08 2M6S-A nrPDB 44 3e-04 5LJI-A nrPDB 42 7e-04 4HEQ-A nrPDB 39 0.007 5V57-A nrPDB 38 0.020 2HNA-A nrPDB 37 0.025 2FCR-A nrPDB 37 0.038 4OXX-A nrPDB 37 0.040 5XRA-A nrPDB 36 0.059 6GAQ-A nrPDB 36 0.066 5ZKP-A nrPDB 35 0.12 3F6S-A nrPDB 33 0.34 2V5U-A nrPDB 33 0.35 1AG9-A nrPDB 33 0.53 1CZN-A nrPDB 33 0.60 1KRH-A nrPDB 33 0.61 5F1Q-A nrPDB 32 1.2 5YOB-A nrPDB 32 1.3 3KAQ-A nrPDB 31 1.5 5OGX-A nrPDB 31 1.5 1DPE-A nrPDB 31 1.8 4U9U-A nrPDB 31 1.8 4W5W-A nrPDB 31 1.9 2YXG-A nrPDB 31 2.1 5IM2-A nrPDB 30 2.8 4EH1-A nrPDB 30 3.3 4P6V-F nrPDB 30 4.4 3OZU-A nrPDB 29 5.8 3R0X-A nrPDB 29 6.2 3SS9-X nrPDB 29 7.3 3WBE-A nrPDB 28 9.4 >5GXU-A nrPDB Length = 640 Score = 1335 bits (3456), Expect = 0.0, Method: Compositional matrix adjust. Identities = 639/639 (100%), Positives = 639/639 (100%) Query: 73 RRSGSGNSKRVEPLKPLVIKPREEEIDDGRKKVTIFFGTQTGTAEGFAKALGEEAKARYE 132 RRSGSGNSKRVEPLKPLVIKPREEEIDDGRKKVTIFFGTQTGTAEGFAKALGEEAKARYE Sbjct: 2 RRSGSGNSKRVEPLKPLVIKPREEEIDDGRKKVTIFFGTQTGTAEGFAKALGEEAKARYE 61 Query: 133 KTRFKIVDLDDYAADDDEYEEKLKKEDVAFFFLATYGDGEPTDNAARFYKWFTEGNDRGE 192 KTRFKIVDLDDYAADDDEYEEKLKKEDVAFFFLATYGDGEPTDNAARFYKWFTEGNDRGE Sbjct: 62 KTRFKIVDLDDYAADDDEYEEKLKKEDVAFFFLATYGDGEPTDNAARFYKWFTEGNDRGE 121 Query: 193 WLKNLKYGVFGLGNRQYEHFNKVAKVVDDILVEQGAQRLVQVGLGDDDQCIEDDFTAWRE 252 WLKNLKYGVFGLGNRQYEHFNKVAKVVDDILVEQGAQRLVQVGLGDDDQCIEDDFTAWRE Sbjct: 122 WLKNLKYGVFGLGNRQYEHFNKVAKVVDDILVEQGAQRLVQVGLGDDDQCIEDDFTAWRE 181 Query: 253 ALWPELDTILREEGDTAVATPYTAAVLEYRVSIHDSEDAKFNDINMANGNGYTVFDAQHP 312 ALWPELDTILREEGDTAVATPYTAAVLEYRVSIHDSEDAKFNDINMANGNGYTVFDAQHP Sbjct: 182 ALWPELDTILREEGDTAVATPYTAAVLEYRVSIHDSEDAKFNDINMANGNGYTVFDAQHP 241 Query: 313 YKANVAVKRELHTPESDRSCIHLEFDIAGSGLTYETGDHVGVLCDNLSETVDEALRLLDM 372 YKANVAVKRELHTPESDRSCIHLEFDIAGSGLTYETGDHVGVLCDNLSETVDEALRLLDM Sbjct: 242 YKANVAVKRELHTPESDRSCIHLEFDIAGSGLTYETGDHVGVLCDNLSETVDEALRLLDM 301 Query: 373 SPDTYFSLHAEKEDGTPISSSLPPPFPPCNLRTALTRYACLLSSPKKSALVALAAHASDP 432 SPDTYFSLHAEKEDGTPISSSLPPPFPPCNLRTALTRYACLLSSPKKSALVALAAHASDP Sbjct: 302 SPDTYFSLHAEKEDGTPISSSLPPPFPPCNLRTALTRYACLLSSPKKSALVALAAHASDP 361 Query: 433 TEAERLKHLASPAGKDEYSKWVVESQRSLLEVMAEFPSAKPPLGVFFAGVAPRLQPRFYS 492 TEAERLKHLASPAGKDEYSKWVVESQRSLLEVMAEFPSAKPPLGVFFAGVAPRLQPRFYS Sbjct: 362 TEAERLKHLASPAGKDEYSKWVVESQRSLLEVMAEFPSAKPPLGVFFAGVAPRLQPRFYS 421 Query: 493 ISSSPKIAETRIHVTCALVYEKMPTGRIHKGVCSTWMKNAVPYEKSENCSSAPIFVRQSN 552 ISSSPKIAETRIHVTCALVYEKMPTGRIHKGVCSTWMKNAVPYEKSENCSSAPIFVRQSN Sbjct: 422 ISSSPKIAETRIHVTCALVYEKMPTGRIHKGVCSTWMKNAVPYEKSENCSSAPIFVRQSN 481 Query: 553 FKLPSDSKVPIIMIGPGTGLAPFRGFLQERLALVESGVELGPSVLFFGCRNRRMDFIYEE 612 FKLPSDSKVPIIMIGPGTGLAPFRGFLQERLALVESGVELGPSVLFFGCRNRRMDFIYEE Sbjct: 482 FKLPSDSKVPIIMIGPGTGLAPFRGFLQERLALVESGVELGPSVLFFGCRNRRMDFIYEE 541 Query: 613 ELQRFVESGALAELSVAFSREGPTKEYVQHKMMDKASDIWNMISQGAYLYVCGDAKGMAR 672 ELQRFVESGALAELSVAFSREGPTKEYVQHKMMDKASDIWNMISQGAYLYVCGDAKGMAR Sbjct: 542 ELQRFVESGALAELSVAFSREGPTKEYVQHKMMDKASDIWNMISQGAYLYVCGDAKGMAR 601 Query: 673 DVHRSLHTIAQEQGSMDSTKAEGFVKNLQTSGRYLRDVW 711 DVHRSLHTIAQEQGSMDSTKAEGFVKNLQTSGRYLRDVW Sbjct: 602 DVHRSLHTIAQEQGSMDSTKAEGFVKNLQTSGRYLRDVW 640 >6J79-A nrPDB Length = 871 Score = 454 bits (1167), Expect = e-128, Method: Compositional matrix adjust. Identities = 250/625 (40%), Positives = 369/625 (59%), Gaps = 31/625 (4%) Query: 96 EEIDDGRKKVTIFFGTQTGTAEGFAKALGEEAKARYEKTRFKIVDLDDYAADDDEYEEKL 155 E++ + + +F+G+QTGTAE FA L ++A RY R D ++Y D ++ Sbjct: 268 EKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAH-RY-GMRGMSADPEEYDLADLSSLPEI 325 Query: 156 KKEDVAFFFLATYGDGEPTDNAARFYKWFTEGNDRGEWLKNLKYGVFGLGNRQYEHFNKV 215 K + F +ATYG+G+PTDNA FY W E + L +K+ VFGLGN+ YEHFN + Sbjct: 326 DK-SLVVFCMATYGEGDPTDNAQDFYDWLQETDVD---LTGVKFAVFGLGNKTYEHFNAM 381 Query: 216 AKVVDDILVEQGAQRLVQVGLGDDDQCIEDDFTAWREALWPELDTILREEGDTAVATPYT 275 K VD L + GAQR+ ++GLGDDD +E+DF WRE WP + E Sbjct: 382 GKYVDQRLEQLGAQRIFELGLGDDDGNLEEDFITWREQFWPAVCEFFGVEA--------- 432 Query: 276 AAVLEYRVSIHDSED-AKFNDINMANGNGYT----VFDAQHPYKANVAVKRELHTPESDR 330 +++ +Y + +H+ D AK M Y FDA++P+ A V R+L+ ++R Sbjct: 433 SSIRQYELVVHEDMDVAKVYTGEMGRLKSYENQKPPFDAKNPFLAAVTANRKLNQG-TER 491 Query: 331 SCIHLEFDIAGSGLTYETGDHVGVLCDNLSETVDEALRLLDMSPDTYFSLHAEKEDGTPI 390 +HLE DI+ S + YE+GDHV V N S V++ +L D SL+ E+ Sbjct: 492 HLMHLELDISDSKIRYESGDHVAVYPANDSALVNQIGEILGADLDVIMSLNNLDEE---- 547 Query: 391 SSSLPPPFP-PCNLRTALTRYACLLSSPKKSALVALAAHASDPTEAERLKHLASPAG--K 447 S+ PFP P RTALT Y + + P+ + L LA +AS+P+E E L +AS +G K Sbjct: 548 -SNKKHPFPCPTTYRTALTYYLDITNPPRTNVLYELAQYASEPSEQEHLHKMASSSGEGK 606 Query: 448 DEYSKWVVESQRSLLEVMAEFPSAKPPLGVFFAGVAPRLQPRFYSISSSPKIAETRIHVT 507 + Y WVVE++R +L ++ ++PS +PP+ + PRLQ R+YSI+SS K+ +H+ Sbjct: 607 ELYLSWVVEARRHILAILQDYPSLRPPID-HLCELLPRLQARYYSIASSSKVHPNSVHIC 665 Query: 508 CALVYEKMPTGRIHKGVCSTWMKNAVPYEKSENCSSAPIFVRQSNFKLPSDSKVPIIMIG 567 V + +GR++KGV ++W++ P ++ + P+FVR+S F+LP S P+IM+G Sbjct: 666 AVAVEYEAKSGRVNKGVATSWLRAKEPAGENGGRALVPMFVRKSQFRLPFKSTTPVIMVG 725 Query: 568 PGTGLAPFRGFLQERLALVESGVELGPSVLFFGCRNRRMDFIYEEELQRFVESGALAELS 627 PGTG+APF GF+QER L E G E+G ++L++GCR D++Y EEL RF + GAL +L+ Sbjct: 726 PGTGIAPFMGFIQERAWLREQGKEVGETLLYYGCRRSDEDYLYREELARFHKDGALTQLN 785 Query: 628 VAFSREGPTKEYVQHKMMDKASDIWNMISQ-GAYLYVCGDAKGMARDVHRSLHTIAQEQG 686 VAFSRE K YVQH + +W +I + GA++YVCGDA+ MA+DV + + I E G Sbjct: 786 VAFSREQAHKVYVQHLLKRDREHLWKLIHEGGAHIYVCGDARNMAKDVQNTFYDIVAEFG 845 Query: 687 SMDSTKAEGFVKNLQTSGRYLRDVW 711 M+ T+A +VK L T GRY DVW Sbjct: 846 PMEHTQAVDYVKKLMTKGRYSLDVW 870 >3ES9-A nrPDB Length = 618 Score = 453 bits (1165), Expect = e-127, Method: Compositional matrix adjust. Identities = 251/625 (40%), Positives = 369/625 (59%), Gaps = 31/625 (4%) Query: 96 EEIDDGRKKVTIFFGTQTGTAEGFAKALGEEAKARYEKTRFKIVDLDDYAADDDEYEEKL 155 E++ + + +F+G+QTGTAE FA L ++A RY R D ++Y D ++ Sbjct: 15 EKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAH-RY-GMRGMSADPEEYDLADLSSLPEI 72 Query: 156 KKEDVAFFFLATYGDGEPTDNAARFYKWFTEGNDRGEWLKNLKYGVFGLGNRQYEHFNKV 215 K V F +ATYG+G+PTDNA FY W E + L +K+ VFGLGN+ YEHFN + Sbjct: 73 DKSLVVFC-MATYGEGDPTDNAQDFYDWLQETDVD---LTGVKFAVFGLGNKTYEHFNAM 128 Query: 216 AKVVDDILVEQGAQRLVQVGLGDDDQCIEDDFTAWREALWPELDTILREEGDTAVATPYT 275 K VD L + GAQR+ ++GLGDDD +E+DF WRE WP + E Sbjct: 129 GKYVDQRLEQLGAQRIFELGLGDDDGNLEEDFITWREQFWPAVCEFFGVEA--------- 179 Query: 276 AAVLEYRVSIHDSED-AKFNDINMANGNGYTV----FDAQHPYKANVAVKRELHTPESDR 330 +++ +Y + +H+ D AK M Y FDA++P+ A V R+L+ ++R Sbjct: 180 SSIRQYELVVHEDMDVAKVYTGEMGRLKSYENQKPPFDAKNPFLAAVTANRKLNQG-TER 238 Query: 331 SCIHLEFDIAGSGLTYETGDHVGVLCDNLSETVDEALRLLDMSPDTYFSLHAEKEDGTPI 390 +HLE DI+ S + YE+GDHV V N S V++ +L D SL+ E+ Sbjct: 239 HLMHLELDISDSKIRYESGDHVAVYPANDSALVNQIGEILGADLDVIMSLNNLDEE---- 294 Query: 391 SSSLPPPFP-PCNLRTALTRYACLLSSPKKSALVALAAHASDPTEAERLKHLASPAG--K 447 S+ PFP P RTALT Y + + P+ + L LA +AS+P+E E L +AS +G K Sbjct: 295 -SNKKHPFPCPTTYRTALTYYLDITNPPRTNVLYELAQYASEPSEQEHLHKMASSSGEGK 353 Query: 448 DEYSKWVVESQRSLLEVMAEFPSAKPPLGVFFAGVAPRLQPRFYSISSSPKIAETRIHVT 507 + Y WVVE++R +L ++ ++PS +PP+ + PRLQ R+YSI+SS K+ +H+ Sbjct: 354 ELYLSWVVEARRHILAILQDYPSLRPPID-HLCELLPRLQARYYSIASSSKVHPNSVHIC 412 Query: 508 CALVYEKMPTGRIHKGVCSTWMKNAVPYEKSENCSSAPIFVRQSNFKLPSDSKVPIIMIG 567 V + +GR++KGV ++W++ P ++ + P+FVR+S F+LP S P+IM+G Sbjct: 413 AVAVEYEAKSGRVNKGVATSWLRAKEPAGENGGRALVPMFVRKSQFRLPFKSTTPVIMVG 472 Query: 568 PGTGLAPFRGFLQERLALVESGVELGPSVLFFGCRNRRMDFIYEEELQRFVESGALAELS 627 PGTG+APF GF+QER L E G E+G ++L++GCR D++Y EEL RF + GAL +L+ Sbjct: 473 PGTGIAPFMGFIQERAWLREQGKEVGETLLYYGCRRSDEDYLYREELARFHKDGALTQLN 532 Query: 628 VAFSREGPTKEYVQHKMMDKASDIWNMISQ-GAYLYVCGDAKGMARDVHRSLHTIAQEQG 686 VAFSRE K YVQH + +W +I + GA++YVCGDA+ MA+DV + + I E G Sbjct: 533 VAFSREQAHKVYVQHLLKRDREHLWKLIHEGGAHIYVCGDARNMAKDVQNTFYDIVAEFG 592 Query: 687 SMDSTKAEGFVKNLQTSGRYLRDVW 711 M+ T+A +VK L T GRY DVW Sbjct: 593 PMEHTQAVDYVKKLMTKGRYSLDVW 617 >3QFR-A nrPDB Length = 618 Score = 450 bits (1157), Expect = e-126, Method: Compositional matrix adjust. Identities = 250/630 (39%), Positives = 371/630 (58%), Gaps = 38/630 (6%) Query: 96 EEIDDGRKKVTIFFGTQTGTAEGFAKALGEEAKARYEKTRFKIVDLDDYAADDDEYE--- 152 E++ + + +F+G+QTGTAE FA L ++A RY + +AD +EY+ Sbjct: 12 EKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAH-RY--------GMRGMSADPEEYDLAD 62 Query: 153 -EKLKKEDVAF--FFLATYGDGEPTDNAARFYKWFTEGNDRGEWLKNLKYGVFGLGNRQY 209 L + D A F +ATYG+G+PTDNA FY W E + L +K+ VFGLGN+ Y Sbjct: 63 LSSLPEIDNALVVFCMATYGEGDPTDNAQDFYDWLQETDVD---LSGVKFAVFGLGNKTY 119 Query: 210 EHFNKVAKVVDDILVEQGAQRLVQVGLGDDDQCIEDDFTAWREALWPELDTILREEGDTA 269 EHFN + K VD L + GAQR+ ++GLGDDD +E+DF WRE WP + E Sbjct: 120 EHFNAMGKYVDKRLEQLGAQRIFELGLGDDDGNLEEDFITWREQFWPAVCEHFGVE---- 175 Query: 270 VATPYTAAVLEYRVSIH-DSEDAKFNDINMANGNGYTV----FDAQHPYKANVAVKRELH 324 AT +++ +Y + +H D + AK M Y FDA++P+ A V R+L+ Sbjct: 176 -ATGEESSIRQYELVVHTDIDAAKVYMGEMGRLKSYENQKPPFDAKNPFLAAVTTNRKLN 234 Query: 325 TPESDRSCIHLEFDIAGSGLTYETGDHVGVLCDNLSETVDEALRLLDMSPDTYFSLHAEK 384 ++R +HLE DI+ S + YE+GDHV V N S V++ ++L D SL+ Sbjct: 235 QG-TERHLMHLELDISDSKIRYESGDHVAVYPANDSALVNQLGKILGADLDVVMSLNNLD 293 Query: 385 EDGTPISSSLPPPFP-PCNLRTALTRYACLLSSPKKSALVALAAHASDPTEAERLKHLAS 443 E+ S+ PFP P + RTALT Y + + P+ + L LA +AS+P+E E L+ +AS Sbjct: 294 EE-----SNKKHPFPCPTSYRTALTYYLDITNPPRTNVLYELAQYASEPSEQELLRKMAS 348 Query: 444 PAG--KDEYSKWVVESQRSLLEVMAEFPSAKPPLGVFFAGVAPRLQPRFYSISSSPKIAE 501 +G K+ Y WVVE++R +L ++ + PS +PP+ + PRLQ +YSI+SS K+ Sbjct: 349 SSGEGKELYLSWVVEARRHILAILQDCPSLRPPID-HLCELLPRLQAHYYSIASSSKVHP 407 Query: 502 TRIHVTCALVYEKMPTGRIHKGVCSTWMKNAVPYEKSENCSSAPIFVRQSNFKLPSDSKV 561 +H+ +V + GRI+KGV + W++ P ++ + P+FVR+S F+LP + Sbjct: 408 NSVHICAVVVEYETKAGRINKGVATNWLRAKEPAGENGGRALVPMFVRKSQFRLPFKATT 467 Query: 562 PIIMIGPGTGLAPFRGFLQERLALVESGVELGPSVLFFGCRNRRMDFIYEEELQRFVESG 621 P+IM+GPGTG+APF GF+QER L + G E+G ++L++GCR D++Y EEL +F G Sbjct: 468 PVIMVGPGTGVAPFIGFIQERAWLRQQGKEVGETLLYYGCRRSDEDYLYREELAQFHRDG 527 Query: 622 ALAELSVAFSREGPTKEYVQHKMMDKASDIWNMISQGAYLYVCGDAKGMARDVHRSLHTI 681 AL +L+VAFSRE K YVQH + +W +I GA++YVCGDA+ MARDV + + I Sbjct: 528 ALTQLNVAFSREQSHKVYVQHLLKQDREHLWKLIEGGAHIYVCGDARNMARDVQNTFYDI 587 Query: 682 AQEQGSMDSTKAEGFVKNLQTSGRYLRDVW 711 E G+M+ +A ++K L T GRY DVW Sbjct: 588 VAELGAMEHAQAVDYIKKLMTKGRYSLDVW 617 >3FJO-A nrPDB Length = 637 Score = 405 bits (1041), Expect = e-113, Method: Compositional matrix adjust. Identities = 235/625 (37%), Positives = 355/625 (56%), Gaps = 33/625 (5%) Query: 98 IDDGRKKVTIFFGTQTGTAEGFAKALGEEAKARYEKTRFKIVDLDDYAADDDEYE-EKLK 156 + + K + + +QTGTAE +AK +E A++ +L+ AD + Y+ E L Sbjct: 34 VTENNKNYLVLYASQTGTAEDYAKKFSKELVAKF--------NLNVMCADVENYDFESLN 85 Query: 157 KEDVAF-FFLATYGDGEPTDNAARFYKWFTEGNDRGEWLKNLKYGVFGLGNRQYEHFNKV 215 V F++TYG+G+ D A F + N L NL+Y +FGLGN YE FN Sbjct: 86 DVPVIVSIFISTYGEGDFPDGAVNFEDFIC--NAEAGALSNLRYNMFGLGNSTYEFFNGA 143 Query: 216 AKVVDDILVEQGAQRLVQVGLGDDDQCIED-DFTAWREALWPELDTILREEGDTAVATPY 274 AK + L GA RL ++G DD D D+ AW++++ L L E AT Sbjct: 144 AKKAEKHLSAAGAIRLGKLGEADDGAGTTDEDYMAWKDSILEVLKDELGVE-----ATGE 198 Query: 275 TAAVLEYRVSIH-DSEDAKFNDINMANGNGYTV----FDAQHPYKANVAVKRELHTPESD 329 +++ +Y + +H D + AK M Y FDA++P+ A V R+L+ ++ Sbjct: 199 ESSIRQYELVVHTDIDAAKVYMGEMGRLKSYENQKPPFDAKNPFLAAVTTNRKLNQG-TE 257 Query: 330 RSCIHLEFDIAGSGLTYETGDHVGVLCDNLSETVDEALRLLDMSPDTYFSLHAEKEDGTP 389 R +HLE DI+ S + YE+GDHV V N S V++ ++L D SL+ E+ Sbjct: 258 RHLMHLELDISDSKIRYESGDHVAVYPANDSALVNQLGKILGADLDVVMSLNNLDEE--- 314 Query: 390 ISSSLPPPFP-PCNLRTALTRYACLLSSPKKSALVALAAHASDPTEAERLKHLASPAG-- 446 S+ PFP P + RTALT Y + + P+ + L LA +AS+P+E E L+ +AS +G Sbjct: 315 --SNKKHPFPCPTSYRTALTYYLDITNPPRTNVLYELAQYASEPSEQELLRKMASSSGEG 372 Query: 447 KDEYSKWVVESQRSLLEVMAEFPSAKPPLGVFFAGVAPRLQPRFYSISSSPKIAETRIHV 506 K+ Y WVVE++R +L ++ + PS +PP+ + PRLQ R+YSI+SS K+ +H+ Sbjct: 373 KELYLSWVVEARRHILAILQDCPSLRPPID-HLCELLPRLQARYYSIASSSKVHPNSVHI 431 Query: 507 TCALVYEKMPTGRIHKGVCSTWMKNAVPYEKSENCSSAPIFVRQSNFKLPSDSKVPIIMI 566 +V + GRI+KGV + W++ P ++ + P+FVR+S F+LP + P+IM+ Sbjct: 432 CAVVVEYETKAGRINKGVATNWLRAKEPAGENGGRALVPMFVRKSQFRLPFKATTPVIMV 491 Query: 567 GPGTGLAPFRGFLQERLALVESGVELGPSVLFFGCRNRRMDFIYEEELQRFVESGALAEL 626 GPGTG+APF GF+QER L + G E+G ++L++GCR D++Y EEL +F GAL +L Sbjct: 492 GPGTGVAPFIGFIQERAWLRQQGKEVGETLLYYGCRRSDEDYLYREELAQFHRDGALTQL 551 Query: 627 SVAFSREGPTKEYVQHKMMDKASDIWNMISQGAYLYVCGDAKGMARDVHRSLHTIAQEQG 686 +VAFSRE K YVQH + +W +I GA++YVCGDA+ MARDV + + I E G Sbjct: 552 NVAFSREQSHKVYVQHLLKQDREHLWKLIEGGAHIYVCGDARNMARDVQNTFYDIVAELG 611 Query: 687 SMDSTKAEGFVKNLQTSGRYLRDVW 711 +M+ +A ++K L T GRY DVW Sbjct: 612 AMEHAQAVDYIKKLMTKGRYSLDVW 636 >2BN4-A nrPDB Length = 682 Score = 294 bits (752), Expect = 1e-79, Method: Compositional matrix adjust. Identities = 213/665 (32%), Positives = 328/665 (49%), Gaps = 78/665 (11%) Query: 98 IDDGRKKVTIFFGTQTGTAEGFAKALGEEAKARYEKTRFKIVDLDDYAADDDEYE-EKLK 156 + + K + + +QTGTAE +AK +E A++ +L+ AD + Y+ E L Sbjct: 45 VTENNKNYLVLYASQTGTAEDYAKKFSKELVAKF--------NLNVMCADVENYDFESLN 96 Query: 157 KEDVAF-FFLATYGDGEPTDNAARFYKWFTEGNDRGEWLKNLKYGVFGLGNRQYEHFNKV 215 V F++TYG+G+ D A F + N L NL+Y +FGLGN YE FN Sbjct: 97 DVPVIVSIFISTYGEGDFPDGAVNFEDFIC--NAEAGALSNLRYNMFGLGNSTYEFFNGA 154 Query: 216 AKVVDDILVEQGAQRLVQVGLGDDDQCIED-DFTAWREALWPEL-DTILREEGDTAVATP 273 AK + L GA RL ++G DD D D+ AW++++ L D + +E + + Sbjct: 155 AKKAEKHLSAAGAIRLGKLGEADDGAGTTDEDYMAWKDSILEVLKDELHLDEQEAKFTSQ 214 Query: 274 YTAAVLEYRV--------SIHDSEDAKFNDINMANGNGYTVFDAQHPYKANVAVKRELHT 325 + VL S H + N A+G FD PY A + REL + Sbjct: 215 FQYTVLNEITDSMSLGEPSAHYLPSHQLN--RNADGIQLGPFDLSQPYIAPIVKSRELFS 272 Query: 326 PESDRSCIHLEFDIAGSGLTYETGDHVGVLCDNLSETVDEALRLLDMSPDTYFSLHAEKE 385 +DR+CIH EFD++GS + Y TGDH+ V N E V++ L + ++ P+T F L Sbjct: 273 -SNDRNCIHSEFDLSGSNIKYSTGDHLAVWPSNPLEKVEQFLSIFNLDPETIFDLK---- 327 Query: 386 DGTPISSSLPPPFP-PCNLRTALTRYACLLSSPKKSALVALAAHASDPTEAERLKHLASP 444 P+ ++ PFP P + A+ Y + + +L A + E+L L+ Sbjct: 328 ---PLDPTVKVPFPTPTTIGAAIKHYLEITGPVSRQLFSSLIQFAPNADVKEKLTLLSK- 383 Query: 445 AGKDEYSKWVVESQRSLLEVMAEFPSAKP----PLGVFFAGVAPRLQPRFYSISSSPKIA 500 KD+++ + ++ + + P+ F P++ PR+YSISSS Sbjct: 384 -DKDQFAVEITSKYFNIADALKYLSDGAKWDTVPMQ-FLVESVPQMTPRYYSISSSSLSE 441 Query: 501 ETRIHVTCALVYEKMPTGRIHK-----GVCSTWMKNAVPYEKSENCSSA----------- 544 + +HVT + E P + GV + ++N + + N + Sbjct: 442 KQTVHVTS--IVENFPNPELPDAPPVVGVTTNLLRNIQLAQNNVNIAETNLPVHYDLNGP 499 Query: 545 ---------PIFVRQSNFKLPSDSKVPIIMIGPGTGLAPFRGFLQERLALVES------G 589 P+ VR+SNF+LPS+ P+IMIGPGTG+APFRGF++ER+A +ES Sbjct: 500 RKLFANYKLPVHVRRSNFRLPSNPSTPVIMIGPGTGVAPFRGFIRERVAFLESQKKGGNN 559 Query: 590 VELGPSVLFFGCRNRRMDFIYEEELQRFVES--GALAELSVAFSREGPTKE-YVQHKMMD 646 V LG +LF+G RN DF+Y++E + + G+ E+ VA SR TK+ YVQ K+ D Sbjct: 560 VSLGKHILFYGSRNTD-DFLYQDEWPEYAKKLDGSF-EMVVAHSRLPNTKKVYVQDKLKD 617 Query: 647 KASDIWNMISQGAYLYVCGDAKGMARDVHRSLHTIAQEQGSMDSTKAEGFVKNLQTSGRY 706 ++ MI+ GA++YVCGDAKGMA+ V +L I S+ + +A +K L+TSGRY Sbjct: 618 YEDQVFEMINNGAFIYVCGDAKGMAKGVSTALVGILSRGKSITTDEATELIKMLKTSGRY 677 Query: 707 LRDVW 711 DVW Sbjct: 678 QEDVW 682 >1TLL-A nrPDB Length = 688 Score = 248 bits (634), Expect = 5e-66, Method: Compositional matrix adjust. Identities = 191/668 (28%), Positives = 306/668 (45%), Gaps = 82/668 (12%) Query: 102 RKKVTIFFGTQTGTAEGFAKALGEEAKARYEKTRFKIVDLDDYAADDDEYE-EKLKKEDV 160 R K TI + T+TG ++ +AK L E K + D A +EY+ L+ E + Sbjct: 11 RVKATILYATETGKSQAYAKTLCEIFKHAF----------DAKAMSMEEYDIVHLEHEAL 60 Query: 161 AFFFLATYGDGEPTDNAARFYKWFTE-------GNDRGEW-------------------- 193 +T+G+G+P +N +F E +R + Sbjct: 61 VLVVTSTFGNGDPPENGEKFGCALMEMRHPNSVQEERKSYKVRFNSVSSYSDSRKSSGDG 120 Query: 194 ------------LKNLKYGVFGLGNRQYEHFNKVAKVVDDILVEQGAQRLVQVGLGDDDQ 241 L N+++ VFGLG+R Y HF VD +L E G +R++++ GD+ Sbjct: 121 PDLRDNFESTGPLANVRFSVFGLGSRAYPHFCAFGHAVDTLLEELGGERILKMREGDELC 180 Query: 242 CIEDDFTAWREALWPELDTILREEGDTAVATPYTAAVLEYRVSIHDSEDAKFNDINMANG 301 E+ F W + ++ + D + P + + R + KF +A Sbjct: 181 GQEEAFRTWAKKVFKAACDVFCVGDDVNIEKPNNSLISNDR----SWKRNKFRLTYVAEA 236 Query: 302 ----NGYTVFDAQHPYKANVAVKRELHTPESDRSCIHLEFDIAGSG-LTYETGDHVGVLC 356 G + + A + ++ L +P+S RS I + G+ L Y+ GDH+GV Sbjct: 237 PDLTQGLSNVHKKRVSAARLLSRQNLQSPKSSRSTIFVRLHTNGNQELQYQPGDHLGVFP 296 Query: 357 DNLSETVDEAL-RLLDMSPDTY---FSLHAEKEDGTPISSSLPPP--FPPCNLRTALTRY 410 N + V+ + RL D P + + E+ + S+ PPC + A Y Sbjct: 297 GNHEDLVNALIERLEDAPPANHVVKVEMLEERNTALGVISNWKDESRLPPCTIFQAFKYY 356 Query: 411 ACLLSSPKKSALVALAAHASDPTEAERLKHLASPAGKDEYSKWVVESQRSLLEVMAEFPS 470 + + P L A+ A++ E +RL L G EY +W +++EV+ EFPS Sbjct: 357 LDITTPPTPLQLQQFASLATNEKEKQRL--LVLSKGLQEYEEWKWGKNPTMVEVLEEFPS 414 Query: 471 AKPPLGVFFAGVAPRLQPRFYSISSSPKIAETRIHVTCALV--YEKMPTGRIHKGVCSTW 528 + P LQPR+YSISSSP + +H+T A+V + + G +H GVCS+W Sbjct: 415 IQMP-ATLLLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIVSYHTRDGEGPVHHGVCSSW 473 Query: 529 MKNAVPYEKSENCSSAPIFVRQS-NFKLPSDSKVPIIMIGPGTGLAPFRGFLQER-LALV 586 + + + P FVR + +F LP + +VP I++GPGTG+APFR F Q+R + Sbjct: 474 LN------RIQADDVVPCFVRGAPSFHLPRNPQVPCILVGPGTGIAPFRSFWQQRQFDIQ 527 Query: 587 ESGVELGPSVLFFGCRNRRMDFIYEEELQRFVESGALAELSVAFSRE-GPTKEYVQHKMM 645 G+ P VL FGCR ++D IY EE + G EL A+SRE K+YVQ + Sbjct: 528 HKGMNPCPMVLVFGCRQSKIDHIYREETLQAKNKGVFRELYTAYSREPDRPKKYVQDVLQ 587 Query: 646 DK-ASDIWNMIS-QGAYLYVCGDAKGMARDVHRSLHTIAQEQGSMDSTKAEGFVKNLQTS 703 ++ A ++ + QG ++YVCGD MA DV +++ I +QG + A F+ L+ Sbjct: 588 EQLAESVYRALKEQGGHIYVCGDVT-MAADVLKAIQRIMTQQGKLSEEDAGVFISRLRDD 646 Query: 704 GRYLRDVW 711 RY D++ Sbjct: 647 NRYHEDIF 654 >6EFV-A nrPDB Length = 569 Score = 231 bits (589), Expect = 8e-61, Method: Compositional matrix adjust. Identities = 178/612 (29%), Positives = 286/612 (46%), Gaps = 85/612 (13%) Query: 104 KVTIFFGTQTGTAEGFAKALGEEAKARYEKTRFKIVDLDDYAADDDEYEEKLKKEDVAFF 163 ++TI +QTG A A+AL ++ A K K+V+ DY +++ E + Sbjct: 39 EITIISASQTGNARRVAEALRDDLLA--AKLNVKLVNAGDYKF------KQIASEKLLIV 90 Query: 164 FLATYGDGEPTDNAARFYKWFTEGNDRGEWLKNLKYGVFGLGNRQYEHFNKVAKVVDDIL 223 +T G+GEP + A +K+ + + L+N + VF LG+ YE F + K D L Sbjct: 91 VTSTQGEGEPPEEAVALHKFLF--SKKAPKLENTAFAVFSLGDSSYEFFCQSGKDFDSKL 148 Query: 224 VEQGAQRLVQVGLGDDDQCIEDDFTAWREALWPELDTILREEGDTAVATPYTAAVLEYRV 283 E G +RL+ R + D Y AA E+R Sbjct: 149 AELGGERLLD-----------------------------RVDADV----EYQAAASEWRA 175 Query: 284 SIHDSEDAKFNDINMANGNGYTV--FDAQHPYKANVAVKRELHTPESDRSCIHLEFDIAG 341 + D+ ++ + N + P A+++V +++ S++ H+E D+ Sbjct: 176 RVVDALKSRAPVVATGAVNEIHTSPYSKDAPLVASLSVNQKITGRNSEKDVRHIEIDLGD 235 Query: 342 SGLTYETGDHVGVLCDNLSETVDEALRLLDMSPDTYFSLHAEKEDGTPISSSLPPPFP-P 400 SGL Y+ GD +GV N V E + LL + D ++ + P++ +L F Sbjct: 236 SGLRYQPGDALGVWYQNDPALVKELVELLWLKGDEPVTVEGKT---LPLNEALQWHFELT 292 Query: 401 CNLRTALTRYACLLSSPKKSALVALAAHASDPTEAERLKHLASPAGKDEYSKWVVESQRS 460 N + YA L S LV A +L+H A+ +V+ Sbjct: 293 VNTANIVENYATLTRSETLLPLVGDKA---------KLQHYAATTP-------IVD---- 332 Query: 461 LLEVMAEFPSAKPPLGVFFAGVAPRLQPRFYSISSSPKIAETRIHVTCALVYEKMPTGRI 520 M F A+ + P L PR YSI+SS E +HVT +V + GR Sbjct: 333 ----MVRFSPAQLDAEALINLLRP-LTPRLYSIASSQAEVENEVHVTVGVVRYDV-EGRA 386 Query: 521 HKGVCSTWMKNAVPYEKSENCSSAPIFVRQS-NFKLPSDSKVPIIMIGPGTGLAPFRGFL 579 G S+++ + V E +F+ + NF+LP++ + P+IMIGPGTG+APFR F+ Sbjct: 387 RAGGASSFLADRV-----EEEGEVRVFIEHNDNFRLPANPETPVIMIGPGTGIAPFRAFM 441 Query: 580 QERLALVESGVELGPSVLFFGCRNRRMDFIYEEELQRFVESGALAELSVAFSREGPTKEY 639 Q+R A G + LFFG + DF+Y+ E QR+V+ G L + +A+SR+ K Y Sbjct: 442 QQRAA----DEAPGKNWLFFGNPHFTEDFLYQVEWQRYVKEGVLTRIDLAWSRDQKEKVY 497 Query: 640 VQHKMMDKASDIWNMISQGAYLYVCGDAKGMARDVHRSLHTIAQEQGSMDSTKAEGFVKN 699 VQ K+ ++ +++W I+ GA++YVCGDA MA+DV ++L + E G MD+ A+ F+ Sbjct: 498 VQDKLREQGAELWRWINDGAHIYVCGDANRMAKDVEQALLEVIAEFGGMDTEAADEFLSE 557 Query: 700 LQTSGRYLRDVW 711 L+ RY RDV+ Sbjct: 558 LRVERRYQRDVY 569 >1B1C-A nrPDB Length = 181 Score = 127 bits (320), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 71/160 (44%), Positives = 97/160 (60%), Gaps = 18/160 (11%) Query: 103 KKVTIFFGTQTGTAEGFAKALGEEAKARYEKTRFKIVDLDDYAADDDEYE----EKLKKE 158 + + +F+G+QTGTAE FA L ++A RY + +AD +EY+ L + Sbjct: 18 RNIIVFYGSQTGTAEEFANRLSKDAH-RY--------GMRGMSADPEEYDLADLSSLPEI 68 Query: 159 DVAF--FFLATYGDGEPTDNAARFYKWFTEGNDRGEWLKNLKYGVFGLGNRQYEHFNKVA 216 D A F +ATYG+G+PTDNA FY W E + L +K+ VFGLGN+ YEHFN + Sbjct: 69 DNALVVFCMATYGEGDPTDNAQDFYDWLQETDVD---LSGVKFAVFGLGNKTYEHFNAMG 125 Query: 217 KVVDDILVEQGAQRLVQVGLGDDDQCIEDDFTAWREALWP 256 K VD L + GAQR+ ++GLGDDD +E+DF WRE WP Sbjct: 126 KYVDKRLEQLGAQRIFELGLGDDDGNLEEDFITWREQFWP 165 >1BVY-F nrPDB Length = 191 Score = 69.7 bits (169), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 42/153 (27%), Positives = 76/153 (49%), Gaps = 13/153 (8%) Query: 107 IFFGTQTGTAEGFAKALGEEAKARYEKTRFKIVDLDDYAADDDEYEEKLKKEDVAFFFLA 166 + +G+ GTAEG A+ L + A ++ ++ LD +A + L +E A Sbjct: 26 VLYGSNMGTAEGTARDLADIAMSK--GFAPQVATLDSHAGN-------LPREGAVLIVTA 76 Query: 167 TYGDGEPTDNAARFYKWFTEGNDRGEWLKNLKYGVFGLGNRQY-EHFNKVAKVVDDILVE 225 +Y +G P DNA +F W + + + +K ++Y VFG G++ + + KV +D+ L Sbjct: 77 SY-NGHPPDNAKQFVDWLDQAS--ADEVKGVRYSVFGCGDKNWATTYQKVPAFIDETLAA 133 Query: 226 QGAQRLVQVGLGDDDQCIEDDFTAWREALWPEL 258 +GA+ + G D E + WRE +W ++ Sbjct: 134 KGAENIADRGEADASDDFEGTYEEWREHMWSDV 166 >4H2D-A nrPDB Length = 165 Score = 66.6 bits (161), Expect = 4e-11, Method: Composition-based stats. Identities = 51/154 (33%), Positives = 74/154 (48%), Gaps = 10/154 (6%) Query: 104 KVTIFFGTQTGTAEGFAKALGEEAKARYEKTRFKIVDLDDYAADDDEYEEKLKKEDVAFF 163 ++ + FG+QTGTA+ ++ LG EA+ R R + LD Y + L E + F Sbjct: 9 QLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQA--LDSYPVVN------LINEPLVIF 60 Query: 164 FLATYGDGEPTDNAARFYKWFTEGNDRGEWLKNLKYGVFGLGNRQYEHFNKVAKVVDDIL 223 AT G G+P DN F+++ N L + + V GLG+ Y FN VAK + L Sbjct: 61 VCATTGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRL 120 Query: 224 VEQGAQRLVQVGLGDDDQCIEDDFTA--WREALW 255 ++ G L+ V LGDD + D W LW Sbjct: 121 LQLGGSALLPVCLGDDQHELGPDAAVDPWLRDLW 154 >2B5O-A nrPDB Length = 402 Score = 65.9 bits (159), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 57/209 (27%), Positives = 100/209 (47%), Gaps = 17/209 (8%) Query: 489 RFYSISSSPK--IAETRIHVTCA--LVYEKMPTGRIHKGVCSTWMKNAVPYEKSENCSSA 544 R YSI+S+ + + + C L Y+ +G GVCST++ N +P + + Sbjct: 179 RLYSIASTRHGDMEDNKTVSLCVRQLEYQDPESGETVYGVCSTYLCN-LPVGTDDVKITG 237 Query: 545 PIFVRQSNFKLPSDSKVPIIMIGPGTGLAPFRGFLQERLALVESGVEL-GPSVLFFGCRN 603 P+ LP D ++M+ GTG+APFR FL + G + L FG Sbjct: 238 PV---GKEMLLPDDEDATVVMLATGTGIAPFRAFLWRMFKEQHEDYKFKGKAWLIFGV-P 293 Query: 604 RRMDFIYEEELQRF-VESGALAELSVAFSREGPT----KEYVQHKMMDKASDIWNMISQ- 657 + +Y+++ ++ E+ L+ A SRE T K YVQ ++ + A +++ MI + Sbjct: 294 YTANILYKDDFEKMAAENPDNFRLTYAISREQKTADGGKVYVQSRVSEYADELFEMIQKP 353 Query: 658 GAYLYVCGDAKGMARDVHRSLHTIAQEQG 686 ++Y+CG KGM + + A+++G Sbjct: 354 NTHVYMCG-LKGMQPPIDETFTAEAEKRG 381 >3HR4-A nrPDB Length = 219 Score = 63.2 bits (152), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 46/152 (30%), Positives = 69/152 (45%), Gaps = 18/152 (11%) Query: 102 RKKVTIFFGTQTGTAEGFAKALGEEAKARYEKTRFKIVDLDDYAADDDEYEEKLKKEDVA 161 R +VTI F T+TG +E A LG + K+V +D Y L++E + Sbjct: 40 RVRVTILFATETGKSEALAWDLGALFSCAFNP---KVVCMDKYRLSC------LEEERLL 90 Query: 162 FFFLATYGDGEPTDNAARFYK---WFTEGNDRGEWLKNLKYGVFGLGNRQYEHFNKVAKV 218 +T+G+G+ N + K E N++ +Y VFGLG+ Y F A Sbjct: 91 LVVTSTFGNGDCPGNGEKLKKSLFMLKELNNK------FRYAVFGLGSSMYPRFCAFAHD 144 Query: 219 VDDILVEQGAQRLVQVGLGDDDQCIEDDFTAW 250 +D L GA +L +G GD+ ED F +W Sbjct: 145 IDQKLSHLGASQLTPMGEGDELSGQEDAFRSW 176 >1YKG-A nrPDB Length = 167 Score = 57.4 bits (137), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 39/128 (30%), Positives = 63/128 (49%), Gaps = 10/128 (7%) Query: 105 VTIFFGTQTGTAEGFAKALGEEAKARYEKTRFKIVDLDDYAADDDEYEEKLKKEDVAFFF 164 +TI +QTG A A+AL ++ A K K+V+ DY +++ E + Sbjct: 12 ITIISASQTGNARRVAEALRDDLLA--AKLNVKLVNAGDYKF------KQIASEKLLIVV 63 Query: 165 LATYGDGEPTDNAARFYKWFTEGNDRGEWLKNLKYGVFGLGNRQYEHFNKVAKVVDDILV 224 +T G+GEP + A +K+ + + L+N + VF LG+ YE F + K D L Sbjct: 64 TSTQGEGEPPEEAVALHKFLF--SKKAPKLENTAFAVFSLGDTSYEFFCQSGKDFDSKLA 121 Query: 225 EQGAQRLV 232 E G +RL+ Sbjct: 122 ELGGERLL 129 >2M6S-A nrPDB Length = 149 Score = 43.9 bits (102), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 39/140 (27%), Positives = 63/140 (45%), Gaps = 21/140 (15%) Query: 104 KVTIFFGTQTGTAEGFAKALGEEAKA-----RYEKTRFKIVDLDDYAADDDEYEEKLKKE 158 ++ IF GT G + + EEA+A ++ T F+ +L D+ D+Y Sbjct: 3 EIGIFVGTMYGNS----LLVAEEAEAILTAQGHKATVFEDPELSDWLPYQDKY------- 51 Query: 159 DVAFFFLATYGDGEPTDNAARFYKWFTEGNDRGEWLKNLKYGVFGLGNRQYEHFNKVAKV 218 +T G G+ D+ ++ D + NL+YGV LG+ Y +F K Sbjct: 52 --VLVVTSTTGQGDLPDSIVPLFQGI---KDSLGFQPNLRYGVIALGDSSYVNFCNGGKQ 106 Query: 219 VDDILVEQGAQRLVQVGLGD 238 D +L EQ AQR+ ++ L D Sbjct: 107 FDALLQEQSAQRVGEMLLID 126 >5LJI-A nrPDB Length = 148 Score = 42.4 bits (98), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 30/89 (33%), Positives = 43/89 (48%), Gaps = 8/89 (8%) Query: 159 DVAFFFLATYGDGEPTDNAARFYKWFTEGNDRGEWLKNLKYGVFGLGNRQYEHFNKVAKV 218 D+A TYGDGE D FY+ + N G+ YGV G G+ Y+ F K Sbjct: 50 DIAIVATYTYGDGELPDEMMDFYEDLADLNLNGKI-----YGVVGSGDTFYDEFCKAVDD 104 Query: 219 VDDILVEQGAQR---LVQVGLGDDDQCIE 244 D + V GA++ V+V L +++ IE Sbjct: 105 FDRVFVSTGAEKGSECVKVDLSAEEEDIE 133 >4HEQ-A nrPDB Length = 146 Score = 39.3 bits (90), Expect = 0.007, Method: Compositional matrix adjust. Identities = 35/125 (28%), Positives = 56/125 (44%), Gaps = 10/125 (8%) Query: 104 KVTIFFGTQTGTAEGFAKALGEEAKARYEKTRFKIVDLDDYAADDDEYEEKLKKEDVAFF 163 K I +G+ TG EG A+A+ + + E +V++ D A + DV Sbjct: 3 KALIVYGSTTGNTEGVAEAIAKTLNS--EGMETTVVNVADVTAPG-----LAEGYDVVLL 55 Query: 164 FLATYGDGEPTDNAARFYKWFTEGNDRGEWLKNLKYGVFGLGNRQYEHFNKVAKVVDDIL 223 +T+GD E + F + + + G LK+ K GVFG G+ Y +F V++ Sbjct: 56 GCSTWGDDE-IELQEDFVPLYEDLDRAG--LKDKKVGVFGCGDSSYTYFCGAVDVIEKKA 112 Query: 224 VEQGA 228 E GA Sbjct: 113 EELGA 117 >5V57-A nrPDB Length = 648 Score = 37.7 bits (86), Expect = 0.020, Method: Compositional matrix adjust. Identities = 41/158 (25%), Positives = 62/158 (39%), Gaps = 19/158 (12%) Query: 98 IDDGRKKVTIFFGTQTGTAEGFAKALGEE-AKARYEKTRFKIVDLDDYAADDDEYEEKLK 156 I K I +G+ TG E A+ + E A A YE +D A E + Sbjct: 372 IKSNHAKALIVYGSTTGNTEYTAETIARELADAGYE--------VDSRDAASVEAGGLFE 423 Query: 157 KEDVAFFFLATYGDG--EPTDNAARFYKWFTEGNDRGEWLKNLKYGVFGLGNRQYEHFNK 214 D+ +T+GD E D+ + E +G K FG G+ +E+F Sbjct: 424 GFDLVLLGCSTWGDDSIELQDDFIPLFDSLEETGAQGR-----KVACFGCGDSSWEYFCG 478 Query: 215 VAKVVDDILVEQGAQRLVQVGL--GDDDQCIEDDFTAW 250 +++ L GA+ +VQ GL D + DD W Sbjct: 479 AVDAIEEKLKNLGAE-IVQDGLRIDGDPRAARDDIVGW 515 >2HNA-A nrPDB Length = 147 Score = 37.4 bits (85), Expect = 0.025, Method: Compositional matrix adjust. Identities = 31/126 (24%), Positives = 55/126 (43%), Gaps = 13/126 (10%) Query: 105 VTIFFGTQTGTAEGFAKALGEEAKARYEKTRFKIVDLDDYAADDDEYEEKLKKEDVAFFF 164 +T+ G+ G AE A+ L E + E+ F L +D L + Sbjct: 4 ITLISGSTLGGAEYVAEHLAE----KLEEAGFTTETLHGPLLED------LPASGIWLVI 53 Query: 165 LATYGDGEPTDNAARFYKWFTEGNDRGEWLKNLKYGVFGLGNRQYEHFNKVAKVVDDILV 224 +T+G G+ DN + FY+ E L +++G G+G+R+Y+ F ++ L Sbjct: 54 SSTHGAGDIPDNLSPFYEALQEQKPD---LSAVRFGAIGIGSREYDTFCGAIDKLEAELK 110 Query: 225 EQGAQR 230 GA++ Sbjct: 111 NSGAKQ 116 >2FCR-A nrPDB Length = 173 Score = 36.6 bits (83), Expect = 0.038, Method: Compositional matrix adjust. Identities = 32/128 (25%), Positives = 56/128 (43%), Gaps = 11/128 (8%) Query: 104 KVTIFFGTQTGTAEGFAKALGEEAKARYEKTRFKIVDLDDYAADDDEYEEKLKKEDVAFF 163 K+ IFF T TG A +G+ A+ + +D+DD + LK D+ F Sbjct: 1 KIGIFFSTSTGNTTEVADFIGKTLGAKADAP----IDVDDVTD-----PQALKDYDLLFL 51 Query: 164 FLATYGDGEPTDNAARFYKWFTEGNDRGEWLKNLKYGVFGLGNRQY--EHFNKVAKVVDD 221 T+ G T+ + + F +K+L +FGLG+ + ++F + + D Sbjct: 52 GAPTWNTGADTERSGTSWDEFLYDKLPEVDMKDLPVAIFGLGDAEGYPDNFCDAIEEIHD 111 Query: 222 ILVEQGAQ 229 +QGA+ Sbjct: 112 CFAKQGAK 119 >4OXX-A nrPDB Length = 162 Score = 36.6 bits (83), Expect = 0.040, Method: Compositional matrix adjust. Identities = 38/129 (29%), Positives = 53/129 (41%), Gaps = 13/129 (10%) Query: 107 IFFGTQTGTAEGFAKALGEEAKARYEKTRFKIVDLDDYAADDDEYEEKLKKEDVAFFFLA 166 I +GT+TG AE A + + + + D+ A D D+ F A Sbjct: 5 ILYGTETGNAEACATTISQVLADTVDTKVHDLADMTPRAMLD-------SGADLIVFATA 57 Query: 167 TYGDGEPTDNAARFYKWFTEGNDRGEWLKNLKYGVFGLGNRQYEHFNKVAKVVDDILVEQ 226 TYG+GE A F++ E L L++ VFGLG+ Y FN+ IL Sbjct: 58 TYGEGEFAGGGAAFFETLRETKPD---LSGLRFAVFGLGDSYYTTFNQAGATAATILASL 114 Query: 227 GAQRLVQVG 235 G QVG Sbjct: 115 GG---TQVG 120 >5XRA-A nrPDB Length = 438 Score = 35.8 bits (81), Expect = 0.059, Method: Compositional matrix adjust. Identities = 40/152 (26%), Positives = 61/152 (40%), Gaps = 19/152 (12%) Query: 104 KVTIFFGTQTGTAEGFAKALGEE-AKARYEKTRFKIVDLDDYAADDDEYEEKLKKEDVAF 162 K I +G+ TG E A+ + E A A YE +D A E + D+ Sbjct: 210 KALIVYGSTTGNTEYTAETIARELADAGYE--------VDSRDAASVEAGGLFEGFDLVL 261 Query: 163 FFLATYGDG--EPTDNAARFYKWFTEGNDRGEWLKNLKYGVFGLGNRQYEHFNKVAKVVD 220 +T+GD E D+ + E +G K FG G+ +E+F ++ Sbjct: 262 LGCSTWGDDSIELQDDFIPLFDSLEETGAQGR-----KVACFGCGDSSWEYFCGAVDAIE 316 Query: 221 DILVEQGAQRLVQVGL--GDDDQCIEDDFTAW 250 + L GA+ +VQ GL D + DD W Sbjct: 317 EKLKNLGAE-IVQDGLRIDGDPRAARDDIVGW 347 >6GAQ-A nrPDB Length = 154 Score = 35.8 bits (81), Expect = 0.066, Method: Compositional matrix adjust. Identities = 26/70 (37%), Positives = 36/70 (51%), Gaps = 6/70 (8%) Query: 167 TYGDGEPTDNAARFYKWFTEGNDRGEWLKNLKYGVFGLGNRQYEHFNKVAKVVDDILVEQ 226 T+GDGE A F+ + L K VFG G+ YE F + + ++ LVE+ Sbjct: 65 TWGDGELPFEAEDFHDDLENID-----LAGKKVAVFGSGDTAYELFCEAVTIFEERLVER 119 Query: 227 GAQRLVQVGL 236 GA+ LVQ GL Sbjct: 120 GAE-LVQEGL 128 >5ZKP-A nrPDB Length = 466 Score = 35.0 bits (79), Expect = 0.12, Method: Compositional matrix adjust. Identities = 40/154 (25%), Positives = 62/154 (40%), Gaps = 19/154 (12%) Query: 102 RKKVTIFFGTQTGTAEGFAKALGEE-AKARYEKTRFKIVDLDDYAADDDEYEEKLKKEDV 160 + K I +G+ TG E A+ + E A A YE +D A E + D+ Sbjct: 218 QAKALIVYGSTTGNTEYTAETIARELADAGYE--------VDSRDAASVEAGGLFEGFDL 269 Query: 161 AFFFLATYGDG--EPTDNAARFYKWFTEGNDRGEWLKNLKYGVFGLGNRQYEHFNKVAKV 218 +T+GD E D+ + E +G K FG G+ +E+F Sbjct: 270 VLLGCSTWGDDSIELQDDFIPLFDSLEETGAQGR-----KVACFGCGDSSWEYFCGAVDA 324 Query: 219 VDDILVEQGAQRLVQVGL--GDDDQCIEDDFTAW 250 +++ L GA+ +VQ GL D + DD W Sbjct: 325 IEEKLKNLGAE-IVQDGLRIDGDPRAARDDIVGW 357 >3F6S-A nrPDB Length = 148 Score = 33.5 bits (75), Expect = 0.34, Method: Compositional matrix adjust. Identities = 38/133 (28%), Positives = 53/133 (39%), Gaps = 16/133 (12%) Query: 104 KVTIFFGTQTGTAEGFAKALGEE-AKARYEKTRFKIVDLDDYAADDDEYEEKLKKEDVAF 162 KV I FG+ TG E A+ L E A +E T A D E D Sbjct: 3 KVLIVFGSSTGNTESIAQKLEELIAAGGHEVTLLN--------AADASAENLADGYDAVL 54 Query: 163 FFLATYG--DGEPTDNAARFYKWFTEGNDRGEWLKNLKYGVFGLGNRQYEHFNKVAKVVD 220 F + +G D E D+ F F E + G L K F G+++YEHF ++ Sbjct: 55 FGCSAWGMEDLEMQDD---FLSLFEEFDRIG--LAGRKVAAFASGDQEYEHFCGAVPAIE 109 Query: 221 DILVEQGAQRLVQ 233 + E GA + + Sbjct: 110 ERAKELGATIIAE 122 >2V5U-A nrPDB Length = 169 Score = 33.5 bits (75), Expect = 0.35, Method: Composition-based stats. Identities = 15/46 (32%), Positives = 28/46 (60%), Gaps = 4/46 (8%) Query: 103 KKVTIFFGTQTGTAEGFAKAL----GEEAKARYEKTRFKIVDLDDY 144 KK+ +F+GTQTG E A+ + G + ++ ++ ++ DL+DY Sbjct: 2 KKIGLFYGTQTGKTESVAEIIRDEFGNDVVTLHDVSQAEVTDLNDY 47 >1AG9-A nrPDB Length = 175 Score = 32.7 bits (73), Expect = 0.53, Method: Composition-based stats. Identities = 39/170 (22%), Positives = 67/170 (39%), Gaps = 36/170 (21%) Query: 107 IFFGTQTGTAEGFAKALGEEAKARYEKTRFKIVDLDDYAADDDEYEEKLKKEDVAFFFLA 166 IFFG+ TG E AK + ++ + D+ D A +E L+ D+ + Sbjct: 5 IFFGSDTGNTENIAKMIQKQLGK-------DVADVHDIAKSS---KEDLEAYDILLLGIP 54 Query: 167 TYGDGEPTDNAARFYKWFTEGNDRGEWLKNLKYGVFGLGNRQ--YEHFNKVAKVVDDILV 224 T+ GE + F+ E + G+ + +FG G+++ E+F + DI+ Sbjct: 55 TWYYGEAQCDWDDFFPTLEEIDFNGKLV-----ALFGCGDQEDYAEYFCDALGTIRDIIE 109 Query: 225 EQGAQRL-----------VQVGLGDDDQCI--------EDDFTAWREALW 255 +GA + GL DDD + + + TA R W Sbjct: 110 PRGATIVGHWPTAGYHFEASKGLADDDHFVGLAIDEDRQPELTAERVEKW 159 >1CZN-A nrPDB Length = 169 Score = 32.7 bits (73), Expect = 0.60, Method: Composition-based stats. Identities = 31/128 (24%), Positives = 54/128 (42%), Gaps = 16/128 (12%) Query: 104 KVTIFFGTQTGTAEGFAKALGEEAKARYEKTRFKIVDLDDYAADDDEYEEKLKKEDVAFF 163 K+ +F+GTQTG + A+++ +E IVDL+D A D L D Sbjct: 2 KIGLFYGTQTGVTQTIAESIQQEFGGE------SIVDLNDIANAD---ASDLNAYDYLII 52 Query: 164 FLATYGDGEPTDNAARFYKWFTEGNDRGEWLKNLKYGVFGLGNR--QYEHFNKVAKVVDD 221 T+ GE + Y N +G+ K FG G++ ++F ++++ Sbjct: 53 GCPTWNVGELQSDWEGIYDDLDSVNFQGK-----KVAYFGAGDQVGYSDNFQDAMGILEE 107 Query: 222 ILVEQGAQ 229 + G+Q Sbjct: 108 KISSLGSQ 115 >1KRH-A nrPDB Length = 338 Score = 32.7 bits (73), Expect = 0.61, Method: Compositional matrix adjust. Identities = 22/57 (38%), Positives = 30/57 (52%), Gaps = 5/57 (8%) Query: 558 DSKVPIIMIGPGTGLAPFRGFLQERLALVESGVELGPSVLFFGCRNRRMDFIYEEEL 614 D K P++M+ GTG+APF LQ L + G E P L FG + D + E+L Sbjct: 208 DVKRPVLMLAGGTGIAPFLSMLQ---VLEQKGSE-HPVRLVFGV-TQDCDLVALEQL 259 >5F1Q-A nrPDB Length = 543 Score = 31.6 bits (70), Expect = 1.2, Method: Compositional matrix adjust. Identities = 40/166 (24%), Positives = 68/166 (40%), Gaps = 21/166 (12%) Query: 310 QHPYKANVAVKRELHTPESDRSCIHLEFDIAGSGLTYETGDHVGVLCDNLSETVDEALRL 369 Q PY N +R +SD + I ++ I +TYE G+++ D ETV Sbjct: 382 QRPYNPNA--RRMAEMIQSDWAKIGVKAKI----VTYEWGEYLKRAKDGEHETVMMGWTG 435 Query: 370 LDMSPD----TYFSLHAEKEDGTPISSSLPPPFPPC----------NLRTALTRYACLLS 415 + PD T FS A K+ G+ S PF + R AL + A ++ Sbjct: 436 DNGDPDNFFATLFSCDAAKQ-GSNYSKWCYKPFEDLIQPARAEADHDKRVALYKQAQVVM 494 Query: 416 SPKKSALVALAAHASDPTEAERLKHLASPAGKDEYSKWVVESQRSL 461 + + AL+ + +P E ++ P GK + +++ +L Sbjct: 495 NEQAPALIIAHSTVYEPVRKEVKGYVVDPLGKHHFDNVSLDAGENL 540 >5YOB-A nrPDB Length = 148 Score = 31.6 bits (70), Expect = 1.3, Method: Compositional matrix adjust. Identities = 42/152 (27%), Positives = 63/152 (41%), Gaps = 19/152 (12%) Query: 104 KVTIFFGTQTGTAEGFAKALGEE-AKARYEKTRFKIVDLDDYAADDDEYEEKLKKEDVAF 162 K I +G+ TG E A+ + E A A YE VD D A+ E + D+ Sbjct: 3 KALIVYGSTTGNTEYTAETIARELADAGYE------VDSRDAASV--EAGGLFEGFDLVL 54 Query: 163 FFLATYGDG--EPTDNAARFYKWFTEGNDRGEWLKNLKYGVFGLGNRQYEHFNKVAKVVD 220 +T+GD E D+ + E +G K FG G+ +E+F ++ Sbjct: 55 LGCSTWGDDSIELQDDFIPLFDSLEETGAQGR-----KVACFGCGDSSWEYFCGAVDAIE 109 Query: 221 DILVEQGAQRLVQVGL--GDDDQCIEDDFTAW 250 + L GA+ +VQ GL D + DD W Sbjct: 110 EKLKNLGAE-IVQDGLRIDGDPRAARDDIVGW 140 >3KAQ-A nrPDB Length = 147 Score = 31.2 bits (69), Expect = 1.5, Method: Compositional matrix adjust. Identities = 37/135 (27%), Positives = 59/135 (43%), Gaps = 20/135 (14%) Query: 104 KVTIFFGTQTGTAEGFAKALGE-EAKARYEKTRFKIVDLDDYAADD--DEYEEKLKKEDV 160 KV I FG+ TG E A+ L E A +E T +++ + +AD+ D Y D Sbjct: 2 KVLILFGSSTGNTESIAQKLEELVAAGGHEVT---LLNAAEASADNLADGY-------DA 51 Query: 161 AFFFLATYG--DGEPTDNAARFYKWFTEGNDRGEWLKNLKYGVFGLGNRQYEHFNKVAKV 218 + +G D E D+ F F E + G LK K F G+ +YEH+ Sbjct: 52 VLMGCSAWGMEDLELQDD---FAPLFDEMENMG--LKGKKLAAFASGDMEYEHYCGAVPA 106 Query: 219 VDDILVEQGAQRLVQ 233 +++ GA+ + + Sbjct: 107 IEEKARGLGAEVICE 121 >5OGX-A nrPDB Length = 336 Score = 31.2 bits (69), Expect = 1.5, Method: Compositional matrix adjust. Identities = 16/37 (43%), Positives = 21/37 (56%), Gaps = 3/37 (8%) Query: 551 SNFKLP---SDSKVPIIMIGPGTGLAPFRGFLQERLA 584 +F LP D P+++IG GTGLAP G + LA Sbjct: 195 GDFHLPPPDEDDGGPMVLIGGGTGLAPLVGIARTALA 231 >1DPE-A nrPDB Length = 507 Score = 31.2 bits (69), Expect = 1.8, Method: Compositional matrix adjust. Identities = 35/160 (21%), Positives = 62/160 (38%), Gaps = 19/160 (11%) Query: 310 QHPYKANVAVKRELHTPESDRSCIHLEFDIAGSGLTYETGDHVGVLCDNLSETVDEALRL 369 Q PY N +R ++D + + ++ I +TYE G+++ D +TV Sbjct: 354 QRPYNPNA--RRMAEMIQADWAKVGVQAKI----VTYEWGEYLKRAKDGEHQTVMMGWTG 407 Query: 370 LDMSPDTYFSLH---AEKEDGTPISSSLPPPFPPC----------NLRTALTRYACLLSS 416 + PD +F+ A E G+ S PF N R L + A ++ Sbjct: 408 DNGDPDNFFATEFSCAASEQGSNYSKWCYKPFEDLIQPARATDDHNKRVELYKQAQVVMH 467 Query: 417 PKKSALVALAAHASDPTEAERLKHLASPAGKDEYSKWVVE 456 + AL+ + +P E ++ P GK + +E Sbjct: 468 DQAPALIIAHSTVFEPVRKEVKGYVVDPLGKHHFENVSIE 507 >4U9U-A nrPDB Length = 281 Score = 31.2 bits (69), Expect = 1.8, Method: Compositional matrix adjust. Identities = 20/74 (27%), Positives = 38/74 (51%), Gaps = 9/74 (12%) Query: 558 DSKVPIIMIGPGTGLAPFRGFLQERLALVESGVELGPSVLFFGCRNRRMDFIYEE----- 612 D+ ++ IG G G+AP R + ++L ++S ++ ++G R++R F E+ Sbjct: 144 DTDAEMVFIGGGAGMAPMRSHIFDQLKRLKSKRKMS---YWYGARSKREMFYVEDFDGLA 200 Query: 613 -ELQRFVESGALAE 625 E FV AL++ Sbjct: 201 AENDNFVWHCALSD 214 >4W5W-A nrPDB Length = 391 Score = 30.8 bits (68), Expect = 1.9, Method: Compositional matrix adjust. Identities = 17/45 (37%), Positives = 28/45 (62%), Gaps = 5/45 (11%) Query: 593 GPSVLFFGCRNRRMDFIYEEELQRFVESGALAELS--VAFSREGP 635 G S+ FFG R +Y++E+++FVES + ++ + SREGP Sbjct: 282 GQSIDFFGALRAR---VYDDEVRKFVESLGVEKIGKRLVNSREGP 323 >2YXG-A nrPDB Length = 289 Score = 30.8 bits (68), Expect = 2.1, Method: Compositional matrix adjust. Identities = 16/54 (29%), Positives = 31/54 (57%), Gaps = 2/54 (3%) Query: 602 RNRRMDFI-YEEELQRFVESGALAELSVAFSREGPTKEYVQH-KMMDKASDIWN 653 +N+ +DF EE + +E+G ++V + E PT + +H K+++K D+ N Sbjct: 14 KNKEVDFDGLEENINFLIENGVSGIVAVGTTGESPTLSHEEHKKVIEKVVDVVN 67 >5IM2-A nrPDB Length = 385 Score = 30.4 bits (67), Expect = 2.8, Method: Compositional matrix adjust. Identities = 21/66 (31%), Positives = 27/66 (40%), Gaps = 9/66 (13%) Query: 588 SGVELGPSVLFFGCRNRRMDFIYEEELQRFVESGALAELSVAFSREGPTKEYVQHKMMDK 647 SGV+LG L+F RR S ALA + AFS+ T H M Sbjct: 9 SGVDLGTENLYFQSMQRR---------SLLKTSAALALTAPAFSQAAATVTLKFHTFMAP 59 Query: 648 ASDIWN 653 S++W Sbjct: 60 QSNVWQ 65 >4EH1-A nrPDB Length = 243 Score = 30.0 bits (66), Expect = 3.3, Method: Compositional matrix adjust. Identities = 36/177 (20%), Positives = 74/177 (41%), Gaps = 23/177 (12%) Query: 489 RFYSISSSPKIAETRIHVTCALVYEKMPTGRIHKGVCSTWMKNAVPYEKSENCSSAPIFV 548 R YS+S + E RI V ++ G + G+ S ++ N V + S ++ Sbjct: 55 RQYSLSHASNGREYRISV------KREGVGSDNPGLVSHYLHNNV-----KVGDSVKLYA 103 Query: 549 RQSNFKLPSDSKVPIIMIGPGTGLAPFRGFLQERLALVESGVELGPSVLFFGCRNRRMDF 608 +F + + P+++I G G P + L +SGV + C + + Sbjct: 104 PAGDF-FYVERERPVVLISAGVGATPMQAILHTLAKQNKSGV-----TYLYACNSAKEHT 157 Query: 609 IYEEELQRFVESGALAELSVAFSREGPTKEYVQHKMMDKASDIWNMISQGAYLYVCG 665 +E Q + G + ++ + R+ + +Q +M + +++ I G + Y+CG Sbjct: 158 FAQETAQLIAQQGWMQQV---WYRDESADDVLQGEM--QLAELILPIEDGDF-YLCG 208 >4P6V-F nrPDB Length = 408 Score = 29.6 bits (65), Expect = 4.4, Method: Compositional matrix adjust. Identities = 15/55 (27%), Positives = 31/55 (56%), Gaps = 3/55 (5%) Query: 558 DSKVPIIMIGPGTGLAPFRGFLQERLALVESGVELGPSVLFFGCRNRRMDFIYEE 612 D+ ++ IG G G+AP R + ++L ++S ++ ++G R++R F E+ Sbjct: 271 DTDAEMVFIGGGAGMAPMRSHIFDQLKRLKSKRKMS---YWYGARSKREMFYVED 322 >3OZU-A nrPDB Length = 403 Score = 29.3 bits (64), Expect = 5.8, Method: Compositional matrix adjust. Identities = 46/178 (25%), Positives = 66/178 (37%), Gaps = 37/178 (20%) Query: 443 SPAGKDEYSKWVVESQRSLLEVMAEF---PSAKPPLGVF----FAGVA---PRL---QPR 489 P G + +V+ +R +V+ F P+ P+ F + VA P L Q R Sbjct: 147 QPGGWKGWRTFVIREKRPESDVITSFILEPADGGPVVNFEPGQYTSVAIDVPALGLQQIR 206 Query: 490 FYSISSSPKIAETRIHVTCALVYEKMP---TGRIHKGV-CSTWMKNAVPYEKSENCSSAP 545 YS+S P RI V + P + +H V +K A PY Sbjct: 207 QYSLSDMPNGRSYRISVKREGGGPQPPGYVSNLLHDHVNVGDQVKLAAPY---------- 256 Query: 546 IFVRQSNFKLPSDSKVPIIMIGPGTGLAPFRGFLQERLALVESGVELGPSVLFFGCRN 603 +F + D+K PI++I G GL P L+ L V V G RN Sbjct: 257 -----GSFHIDVDAKTPIVLISGGVGLTPMVSMLKVALQAPPRQV-----VFVHGARN 304 >3R0X-A nrPDB Length = 448 Score = 29.3 bits (64), Expect = 6.2, Method: Compositional matrix adjust. Identities = 17/71 (23%), Positives = 36/71 (50%), Gaps = 2/71 (2%) Query: 266 GDTAVATPYTAAVLEYRVSIHDSEDAKFNDINMANGNGYTVFDAQHPYKANVAVKRELHT 325 G+ ++ +A + ++V++H S DA+ +G TV + + Y VAV++ Sbjct: 167 GNLGLSIGIMSACIGFKVTVHMSADARAWKKAKLRSHGVTVVEYEDDY--GVAVEQGRKA 224 Query: 326 PESDRSCIHLE 336 +SD +C ++ Sbjct: 225 AQSDPNCFFID 235 >3SS9-X nrPDB Length = 442 Score = 28.9 bits (63), Expect = 7.3, Method: Compositional matrix adjust. Identities = 22/101 (21%), Positives = 46/101 (45%), Gaps = 12/101 (11%) Query: 243 IEDDFTAWREALWPELDTILRE-------EGDTAVATPYTAAVLEYRVSIHDSEDAKFND 295 ++DD++ + L PE + G+ ++ +A + ++V++H S DA+ Sbjct: 142 LDDDYS---KLLSPEFKQFFSQYSIAVGSTGNLGLSIGIMSARIGFKVTVHMSADARAWK 198 Query: 296 INMANGNGYTVFDAQHPYKANVAVKRELHTPESDRSCIHLE 336 +G TV + + Y VAV+ +SD +C ++ Sbjct: 199 KAKLRSHGVTVVEYEQDY--GVAVEEGRKAAQSDPNCFFID 237 >3WBE-A nrPDB Length = 489 Score = 28.5 bits (62), Expect = 9.4, Method: Compositional matrix adjust. Identities = 27/106 (25%), Positives = 43/106 (40%), Gaps = 18/106 (16%) Query: 193 WLKNLKYGVFGLGNRQYEHFNKVAKVVDDILVEQGAQRLVQVGLGDDDQCIEDDFTAWRE 252 W + GV + +H+NK+ D L+ +G Q V + D Q +ED + W + Sbjct: 94 WSRIYPNGVGQVNQAGIDHYNKLI----DALLAKGIQPYVTLYHWDLPQALEDKYKGWLD 149 Query: 253 -------ALWPELDTILREEGD-----TAVATPYTAAVLEYRVSIH 286 A + E T RE GD + P+T A+ Y + Sbjct: 150 RQIVDDFAAYAE--TCFREFGDRVKHWITLNQPHTVAIQGYDAGLQ 193 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 5GXU-A nrPDB 929 0.0 3QFR-A nrPDB 856 0.0 6J79-A nrPDB 845 0.0 3ES9-A nrPDB 845 0.0 3FJO-A nrPDB 822 0.0 1TLL-A nrPDB 660 0.0 2BN4-A nrPDB 639 0.0 6EFV-A nrPDB 609 e-174 2B5O-A nrPDB 232 4e-61 1B1C-A nrPDB 214 9e-56 3HR4-A nrPDB 162 5e-40 1BVY-F nrPDB 156 4e-38 4H2D-A nrPDB 148 8e-36 1YKG-A nrPDB 141 1e-33 2M6S-A nrPDB 124 9e-29 5LJI-A nrPDB 103 2e-22 Sequences not found previously or not previously below threshold: 2HNA-A nrPDB 81 2e-15 4OXX-A nrPDB 79 6e-15 5B3K-A nrPDB 77 2e-14 5V57-A nrPDB 77 3e-14 5XRA-A nrPDB 77 3e-14 5ZKP-A nrPDB 76 4e-14 6GAQ-A nrPDB 76 5e-14 4HEQ-A nrPDB 74 2e-13 5YOB-A nrPDB 74 2e-13 5VEG-A nrPDB 72 9e-13 6FSI-A nrPDB 64 2e-10 3F6S-A nrPDB 63 6e-10 3KAQ-A nrPDB 59 9e-09 1KRH-A nrPDB 55 1e-07 3OZU-A nrPDB 50 3e-06 5OGX-A nrPDB 50 4e-06 2FCR-A nrPDB 49 7e-06 1CZN-A nrPDB 48 1e-05 2V5U-A nrPDB 48 2e-05 4EH1-A nrPDB 48 2e-05 2WC1-A nrPDB 45 1e-04 3W2G-A nrPDB 44 2e-04 1YOB-A nrPDB 44 2e-04 1UMK-A nrPDB 44 2e-04 2R6H-A nrPDB 43 5e-04 5THX-A nrPDB 42 0.001 4B4D-A nrPDB 42 0.001 1AG9-A nrPDB 41 0.001 2BMV-A nrPDB 41 0.003 1A8P-A nrPDB 37 0.020 4G1B-A nrPDB 37 0.020 6O0A-A nrPDB 37 0.023 4U9U-A nrPDB 37 0.032 4P6V-F nrPDB 37 0.032 4WQM-A nrPDB 36 0.042 2PIA-A nrPDB 36 0.054 2VNH-A nrPDB 35 0.091 3FPK-A nrPDB 34 0.27 1TLB-A nrPDB 34 0.31 2QDX-A nrPDB 33 0.46 1FDR-A nrPDB 33 0.47 1TK1-A nrPDB 32 1.2 1GVH-A nrPDB 32 1.2 5MWL-A nrPDB 31 1.4 2EIX-A nrPDB 31 1.5 6F4A-A nrPDB 31 1.5 5UFA-A nrPDB 31 1.6 4FK8-A nrPDB 31 2.0 2RCQ-A nrPDB 31 2.3 5J5Z-A nrPDB 31 2.3 6D35-A nrPDB 30 3.4 1EII-A nrPDB 30 4.7 >5GXU-A nrPDB Length = 640 Score = 929 bits (2401), Expect = 0.0, Method: Composition-based stats. Identities = 639/639 (100%), Positives = 639/639 (100%) Query: 73 RRSGSGNSKRVEPLKPLVIKPREEEIDDGRKKVTIFFGTQTGTAEGFAKALGEEAKARYE 132 RRSGSGNSKRVEPLKPLVIKPREEEIDDGRKKVTIFFGTQTGTAEGFAKALGEEAKARYE Sbjct: 2 RRSGSGNSKRVEPLKPLVIKPREEEIDDGRKKVTIFFGTQTGTAEGFAKALGEEAKARYE 61 Query: 133 KTRFKIVDLDDYAADDDEYEEKLKKEDVAFFFLATYGDGEPTDNAARFYKWFTEGNDRGE 192 KTRFKIVDLDDYAADDDEYEEKLKKEDVAFFFLATYGDGEPTDNAARFYKWFTEGNDRGE Sbjct: 62 KTRFKIVDLDDYAADDDEYEEKLKKEDVAFFFLATYGDGEPTDNAARFYKWFTEGNDRGE 121 Query: 193 WLKNLKYGVFGLGNRQYEHFNKVAKVVDDILVEQGAQRLVQVGLGDDDQCIEDDFTAWRE 252 WLKNLKYGVFGLGNRQYEHFNKVAKVVDDILVEQGAQRLVQVGLGDDDQCIEDDFTAWRE Sbjct: 122 WLKNLKYGVFGLGNRQYEHFNKVAKVVDDILVEQGAQRLVQVGLGDDDQCIEDDFTAWRE 181 Query: 253 ALWPELDTILREEGDTAVATPYTAAVLEYRVSIHDSEDAKFNDINMANGNGYTVFDAQHP 312 ALWPELDTILREEGDTAVATPYTAAVLEYRVSIHDSEDAKFNDINMANGNGYTVFDAQHP Sbjct: 182 ALWPELDTILREEGDTAVATPYTAAVLEYRVSIHDSEDAKFNDINMANGNGYTVFDAQHP 241 Query: 313 YKANVAVKRELHTPESDRSCIHLEFDIAGSGLTYETGDHVGVLCDNLSETVDEALRLLDM 372 YKANVAVKRELHTPESDRSCIHLEFDIAGSGLTYETGDHVGVLCDNLSETVDEALRLLDM Sbjct: 242 YKANVAVKRELHTPESDRSCIHLEFDIAGSGLTYETGDHVGVLCDNLSETVDEALRLLDM 301 Query: 373 SPDTYFSLHAEKEDGTPISSSLPPPFPPCNLRTALTRYACLLSSPKKSALVALAAHASDP 432 SPDTYFSLHAEKEDGTPISSSLPPPFPPCNLRTALTRYACLLSSPKKSALVALAAHASDP Sbjct: 302 SPDTYFSLHAEKEDGTPISSSLPPPFPPCNLRTALTRYACLLSSPKKSALVALAAHASDP 361 Query: 433 TEAERLKHLASPAGKDEYSKWVVESQRSLLEVMAEFPSAKPPLGVFFAGVAPRLQPRFYS 492 TEAERLKHLASPAGKDEYSKWVVESQRSLLEVMAEFPSAKPPLGVFFAGVAPRLQPRFYS Sbjct: 362 TEAERLKHLASPAGKDEYSKWVVESQRSLLEVMAEFPSAKPPLGVFFAGVAPRLQPRFYS 421 Query: 493 ISSSPKIAETRIHVTCALVYEKMPTGRIHKGVCSTWMKNAVPYEKSENCSSAPIFVRQSN 552 ISSSPKIAETRIHVTCALVYEKMPTGRIHKGVCSTWMKNAVPYEKSENCSSAPIFVRQSN Sbjct: 422 ISSSPKIAETRIHVTCALVYEKMPTGRIHKGVCSTWMKNAVPYEKSENCSSAPIFVRQSN 481 Query: 553 FKLPSDSKVPIIMIGPGTGLAPFRGFLQERLALVESGVELGPSVLFFGCRNRRMDFIYEE 612 FKLPSDSKVPIIMIGPGTGLAPFRGFLQERLALVESGVELGPSVLFFGCRNRRMDFIYEE Sbjct: 482 FKLPSDSKVPIIMIGPGTGLAPFRGFLQERLALVESGVELGPSVLFFGCRNRRMDFIYEE 541 Query: 613 ELQRFVESGALAELSVAFSREGPTKEYVQHKMMDKASDIWNMISQGAYLYVCGDAKGMAR 672 ELQRFVESGALAELSVAFSREGPTKEYVQHKMMDKASDIWNMISQGAYLYVCGDAKGMAR Sbjct: 542 ELQRFVESGALAELSVAFSREGPTKEYVQHKMMDKASDIWNMISQGAYLYVCGDAKGMAR 601 Query: 673 DVHRSLHTIAQEQGSMDSTKAEGFVKNLQTSGRYLRDVW 711 DVHRSLHTIAQEQGSMDSTKAEGFVKNLQTSGRYLRDVW Sbjct: 602 DVHRSLHTIAQEQGSMDSTKAEGFVKNLQTSGRYLRDVW 640 >3QFR-A nrPDB Length = 618 Score = 856 bits (2211), Expect = 0.0, Method: Composition-based stats. Identities = 245/624 (39%), Positives = 366/624 (58%), Gaps = 26/624 (4%) Query: 96 EEIDDGRKKVTIFFGTQTGTAEGFAKALGEEAKARYEKTRFKIVDLDDYAADDDEYEEKL 155 E++ + + +F+G+QTGTAE FA L ++A R D ++Y D ++ Sbjct: 12 EKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHR--YGMRGMSADPEEYDLADLSSLPEI 69 Query: 156 KKEDVAFFFLATYGDGEPTDNAARFYKWFTEGNDRGEWLKNLKYGVFGLGNRQYEHFNKV 215 + F +ATYG+G+PTDNA FY W E + L +K+ VFGLGN+ YEHFN + Sbjct: 70 DN-ALVVFCMATYGEGDPTDNAQDFYDWLQETDVD---LSGVKFAVFGLGNKTYEHFNAM 125 Query: 216 AKVVDDILVEQGAQRLVQVGLGDDDQCIEDDFTAWREALWPELDTILREEGDTAVATPYT 275 K VD L + GAQR+ ++GLGDDD +E+DF WRE WP + E AT Sbjct: 126 GKYVDKRLEQLGAQRIFELGLGDDDGNLEEDFITWREQFWPAVCEHFGVE-----ATGEE 180 Query: 276 AAVLEYRVSIH-DSEDAKFNDINMANGNGYT----VFDAQHPYKANVAVKRELHTPESDR 330 +++ +Y + +H D + AK M Y FDA++P+ A V R+L+ ++R Sbjct: 181 SSIRQYELVVHTDIDAAKVYMGEMGRLKSYENQKPPFDAKNPFLAAVTTNRKLNQG-TER 239 Query: 331 SCIHLEFDIAGSGLTYETGDHVGVLCDNLSETVDEALRLLDMSPDTYFSLHAEKEDGTPI 390 +HLE DI+ S + YE+GDHV V N S V++ ++L D SL+ E+ Sbjct: 240 HLMHLELDISDSKIRYESGDHVAVYPANDSALVNQLGKILGADLDVVMSLNNLDEE---- 295 Query: 391 SSSLPPPFP-PCNLRTALTRYACLLSSPKKSALVALAAHASDPTEAERLKHLASPAG--K 447 S+ PFP P + RTALT Y + + P+ + L LA +AS+P+E E L+ +AS +G K Sbjct: 296 -SNKKHPFPCPTSYRTALTYYLDITNPPRTNVLYELAQYASEPSEQELLRKMASSSGEGK 354 Query: 448 DEYSKWVVESQRSLLEVMAEFPSAKPPLGVFFAGVAPRLQPRFYSISSSPKIAETRIHVT 507 + Y WVVE++R +L ++ + PS +PP+ + PRLQ +YSI+SS K+ +H+ Sbjct: 355 ELYLSWVVEARRHILAILQDCPSLRPPID-HLCELLPRLQAHYYSIASSSKVHPNSVHIC 413 Query: 508 CALVYEKMPTGRIHKGVCSTWMKNAVPYEKSENCSSAPIFVRQSNFKLPSDSKVPIIMIG 567 +V + GRI+KGV + W++ P ++ + P+FVR+S F+LP + P+IM+G Sbjct: 414 AVVVEYETKAGRINKGVATNWLRAKEPAGENGGRALVPMFVRKSQFRLPFKATTPVIMVG 473 Query: 568 PGTGLAPFRGFLQERLALVESGVELGPSVLFFGCRNRRMDFIYEEELQRFVESGALAELS 627 PGTG+APF GF+QER L + G E+G ++L++GCR D++Y EEL +F GAL +L+ Sbjct: 474 PGTGVAPFIGFIQERAWLRQQGKEVGETLLYYGCRRSDEDYLYREELAQFHRDGALTQLN 533 Query: 628 VAFSREGPTKEYVQHKMMDKASDIWNMISQGAYLYVCGDAKGMARDVHRSLHTIAQEQGS 687 VAFSRE K YVQH + +W +I GA++YVCGDA+ MARDV + + I E G+ Sbjct: 534 VAFSREQSHKVYVQHLLKQDREHLWKLIEGGAHIYVCGDARNMARDVQNTFYDIVAELGA 593 Query: 688 MDSTKAEGFVKNLQTSGRYLRDVW 711 M+ +A ++K L T GRY DVW Sbjct: 594 MEHAQAVDYIKKLMTKGRYSLDVW 617 >6J79-A nrPDB Length = 871 Score = 845 bits (2183), Expect = 0.0, Method: Composition-based stats. Identities = 248/625 (39%), Positives = 367/625 (58%), Gaps = 31/625 (4%) Query: 96 EEIDDGRKKVTIFFGTQTGTAEGFAKALGEEAKARYEKTRFKIVDLDDYAADDDEYEEKL 155 E++ + + +F+G+QTGTAE FA L ++A R D ++Y D ++ Sbjct: 268 EKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHR--YGMRGMSADPEEYDLADLSSLPEI 325 Query: 156 KKEDVAFFFLATYGDGEPTDNAARFYKWFTEGNDRGEWLKNLKYGVFGLGNRQYEHFNKV 215 K + F +ATYG+G+PTDNA FY W E + L +K+ VFGLGN+ YEHFN + Sbjct: 326 DK-SLVVFCMATYGEGDPTDNAQDFYDWLQETDVD---LTGVKFAVFGLGNKTYEHFNAM 381 Query: 216 AKVVDDILVEQGAQRLVQVGLGDDDQCIEDDFTAWREALWPELDTILREEGDTAVATPYT 275 K VD L + GAQR+ ++GLGDDD +E+DF WRE WP + E Sbjct: 382 GKYVDQRLEQLGAQRIFELGLGDDDGNLEEDFITWREQFWPAVCEFFGVEA--------- 432 Query: 276 AAVLEYRVSIHDSED-AKFNDINMANGNGYT----VFDAQHPYKANVAVKRELHTPESDR 330 +++ +Y + +H+ D AK M Y FDA++P+ A V R+L+ ++R Sbjct: 433 SSIRQYELVVHEDMDVAKVYTGEMGRLKSYENQKPPFDAKNPFLAAVTANRKLNQG-TER 491 Query: 331 SCIHLEFDIAGSGLTYETGDHVGVLCDNLSETVDEALRLLDMSPDTYFSLHAEKEDGTPI 390 +HLE DI+ S + YE+GDHV V N S V++ +L D SL+ E+ Sbjct: 492 HLMHLELDISDSKIRYESGDHVAVYPANDSALVNQIGEILGADLDVIMSLNNLDEE---- 547 Query: 391 SSSLPPPFP-PCNLRTALTRYACLLSSPKKSALVALAAHASDPTEAERLKHLASPAG--K 447 S+ PFP P RTALT Y + + P+ + L LA +AS+P+E E L +AS +G K Sbjct: 548 -SNKKHPFPCPTTYRTALTYYLDITNPPRTNVLYELAQYASEPSEQEHLHKMASSSGEGK 606 Query: 448 DEYSKWVVESQRSLLEVMAEFPSAKPPLGVFFAGVAPRLQPRFYSISSSPKIAETRIHVT 507 + Y WVVE++R +L ++ ++PS +PP+ + PRLQ R+YSI+SS K+ +H+ Sbjct: 607 ELYLSWVVEARRHILAILQDYPSLRPPID-HLCELLPRLQARYYSIASSSKVHPNSVHIC 665 Query: 508 CALVYEKMPTGRIHKGVCSTWMKNAVPYEKSENCSSAPIFVRQSNFKLPSDSKVPIIMIG 567 V + +GR++KGV ++W++ P ++ + P+FVR+S F+LP S P+IM+G Sbjct: 666 AVAVEYEAKSGRVNKGVATSWLRAKEPAGENGGRALVPMFVRKSQFRLPFKSTTPVIMVG 725 Query: 568 PGTGLAPFRGFLQERLALVESGVELGPSVLFFGCRNRRMDFIYEEELQRFVESGALAELS 627 PGTG+APF GF+QER L E G E+G ++L++GCR D++Y EEL RF + GAL +L+ Sbjct: 726 PGTGIAPFMGFIQERAWLREQGKEVGETLLYYGCRRSDEDYLYREELARFHKDGALTQLN 785 Query: 628 VAFSREGPTKEYVQHKMMDKASDIWNMISQ-GAYLYVCGDAKGMARDVHRSLHTIAQEQG 686 VAFSRE K YVQH + +W +I + GA++YVCGDA+ MA+DV + + I E G Sbjct: 786 VAFSREQAHKVYVQHLLKRDREHLWKLIHEGGAHIYVCGDARNMAKDVQNTFYDIVAEFG 845 Query: 687 SMDSTKAEGFVKNLQTSGRYLRDVW 711 M+ T+A +VK L T GRY DVW Sbjct: 846 PMEHTQAVDYVKKLMTKGRYSLDVW 870 >3ES9-A nrPDB Length = 618 Score = 845 bits (2183), Expect = 0.0, Method: Composition-based stats. Identities = 248/625 (39%), Positives = 367/625 (58%), Gaps = 31/625 (4%) Query: 96 EEIDDGRKKVTIFFGTQTGTAEGFAKALGEEAKARYEKTRFKIVDLDDYAADDDEYEEKL 155 E++ + + +F+G+QTGTAE FA L ++A R D ++Y D ++ Sbjct: 15 EKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHR--YGMRGMSADPEEYDLADLSSLPEI 72 Query: 156 KKEDVAFFFLATYGDGEPTDNAARFYKWFTEGNDRGEWLKNLKYGVFGLGNRQYEHFNKV 215 K + F +ATYG+G+PTDNA FY W E + L +K+ VFGLGN+ YEHFN + Sbjct: 73 DK-SLVVFCMATYGEGDPTDNAQDFYDWLQETDVD---LTGVKFAVFGLGNKTYEHFNAM 128 Query: 216 AKVVDDILVEQGAQRLVQVGLGDDDQCIEDDFTAWREALWPELDTILREEGDTAVATPYT 275 K VD L + GAQR+ ++GLGDDD +E+DF WRE WP + E Sbjct: 129 GKYVDQRLEQLGAQRIFELGLGDDDGNLEEDFITWREQFWPAVCEFFGVEA--------- 179 Query: 276 AAVLEYRVSIHDSED-AKFNDINMANGNGYT----VFDAQHPYKANVAVKRELHTPESDR 330 +++ +Y + +H+ D AK M Y FDA++P+ A V R+L+ ++R Sbjct: 180 SSIRQYELVVHEDMDVAKVYTGEMGRLKSYENQKPPFDAKNPFLAAVTANRKLNQG-TER 238 Query: 331 SCIHLEFDIAGSGLTYETGDHVGVLCDNLSETVDEALRLLDMSPDTYFSLHAEKEDGTPI 390 +HLE DI+ S + YE+GDHV V N S V++ +L D SL+ E+ Sbjct: 239 HLMHLELDISDSKIRYESGDHVAVYPANDSALVNQIGEILGADLDVIMSLNNLDEE---- 294 Query: 391 SSSLPPPFP-PCNLRTALTRYACLLSSPKKSALVALAAHASDPTEAERLKHLASPAG--K 447 S+ PFP P RTALT Y + + P+ + L LA +AS+P+E E L +AS +G K Sbjct: 295 -SNKKHPFPCPTTYRTALTYYLDITNPPRTNVLYELAQYASEPSEQEHLHKMASSSGEGK 353 Query: 448 DEYSKWVVESQRSLLEVMAEFPSAKPPLGVFFAGVAPRLQPRFYSISSSPKIAETRIHVT 507 + Y WVVE++R +L ++ ++PS +PP+ + PRLQ R+YSI+SS K+ +H+ Sbjct: 354 ELYLSWVVEARRHILAILQDYPSLRPPID-HLCELLPRLQARYYSIASSSKVHPNSVHIC 412 Query: 508 CALVYEKMPTGRIHKGVCSTWMKNAVPYEKSENCSSAPIFVRQSNFKLPSDSKVPIIMIG 567 V + +GR++KGV ++W++ P ++ + P+FVR+S F+LP S P+IM+G Sbjct: 413 AVAVEYEAKSGRVNKGVATSWLRAKEPAGENGGRALVPMFVRKSQFRLPFKSTTPVIMVG 472 Query: 568 PGTGLAPFRGFLQERLALVESGVELGPSVLFFGCRNRRMDFIYEEELQRFVESGALAELS 627 PGTG+APF GF+QER L E G E+G ++L++GCR D++Y EEL RF + GAL +L+ Sbjct: 473 PGTGIAPFMGFIQERAWLREQGKEVGETLLYYGCRRSDEDYLYREELARFHKDGALTQLN 532 Query: 628 VAFSREGPTKEYVQHKMMDKASDIWNMISQ-GAYLYVCGDAKGMARDVHRSLHTIAQEQG 686 VAFSRE K YVQH + +W +I + GA++YVCGDA+ MA+DV + + I E G Sbjct: 533 VAFSREQAHKVYVQHLLKRDREHLWKLIHEGGAHIYVCGDARNMAKDVQNTFYDIVAEFG 592 Query: 687 SMDSTKAEGFVKNLQTSGRYLRDVW 711 M+ T+A +VK L T GRY DVW Sbjct: 593 PMEHTQAVDYVKKLMTKGRYSLDVW 617 >3FJO-A nrPDB Length = 637 Score = 822 bits (2124), Expect = 0.0, Method: Composition-based stats. Identities = 235/625 (37%), Positives = 355/625 (56%), Gaps = 33/625 (5%) Query: 98 IDDGRKKVTIFFGTQTGTAEGFAKALGEEAKARYEKTRFKIVDLDDYAADDDEYE-EKLK 156 + + K + + +QTGTAE +AK +E A++ +L+ AD + Y+ E L Sbjct: 34 VTENNKNYLVLYASQTGTAEDYAKKFSKELVAKF--------NLNVMCADVENYDFESLN 85 Query: 157 KEDVAF-FFLATYGDGEPTDNAARFYKWFTEGNDRGEWLKNLKYGVFGLGNRQYEHFNKV 215 V F++TYG+G+ D A F + N L NL+Y +FGLGN YE FN Sbjct: 86 DVPVIVSIFISTYGEGDFPDGAVNFEDFIC--NAEAGALSNLRYNMFGLGNSTYEFFNGA 143 Query: 216 AKVVDDILVEQGAQRLVQVGLGDDDQCIED-DFTAWREALWPELDTILREEGDTAVATPY 274 AK + L GA RL ++G DD D D+ AW++++ L L E AT Sbjct: 144 AKKAEKHLSAAGAIRLGKLGEADDGAGTTDEDYMAWKDSILEVLKDELGVE-----ATGE 198 Query: 275 TAAVLEYRVSIH-DSEDAKFNDINMANGNGYT----VFDAQHPYKANVAVKRELHTPESD 329 +++ +Y + +H D + AK M Y FDA++P+ A V R+L+ ++ Sbjct: 199 ESSIRQYELVVHTDIDAAKVYMGEMGRLKSYENQKPPFDAKNPFLAAVTTNRKLNQG-TE 257 Query: 330 RSCIHLEFDIAGSGLTYETGDHVGVLCDNLSETVDEALRLLDMSPDTYFSLHAEKEDGTP 389 R +HLE DI+ S + YE+GDHV V N S V++ ++L D SL+ E+ Sbjct: 258 RHLMHLELDISDSKIRYESGDHVAVYPANDSALVNQLGKILGADLDVVMSLNNLDEE--- 314 Query: 390 ISSSLPPPFP-PCNLRTALTRYACLLSSPKKSALVALAAHASDPTEAERLKHLASPAG-- 446 S+ PFP P + RTALT Y + + P+ + L LA +AS+P+E E L+ +AS +G Sbjct: 315 --SNKKHPFPCPTSYRTALTYYLDITNPPRTNVLYELAQYASEPSEQELLRKMASSSGEG 372 Query: 447 KDEYSKWVVESQRSLLEVMAEFPSAKPPLGVFFAGVAPRLQPRFYSISSSPKIAETRIHV 506 K+ Y WVVE++R +L ++ + PS +PP+ + PRLQ R+YSI+SS K+ +H+ Sbjct: 373 KELYLSWVVEARRHILAILQDCPSLRPPID-HLCELLPRLQARYYSIASSSKVHPNSVHI 431 Query: 507 TCALVYEKMPTGRIHKGVCSTWMKNAVPYEKSENCSSAPIFVRQSNFKLPSDSKVPIIMI 566 +V + GRI+KGV + W++ P ++ + P+FVR+S F+LP + P+IM+ Sbjct: 432 CAVVVEYETKAGRINKGVATNWLRAKEPAGENGGRALVPMFVRKSQFRLPFKATTPVIMV 491 Query: 567 GPGTGLAPFRGFLQERLALVESGVELGPSVLFFGCRNRRMDFIYEEELQRFVESGALAEL 626 GPGTG+APF GF+QER L + G E+G ++L++GCR D++Y EEL +F GAL +L Sbjct: 492 GPGTGVAPFIGFIQERAWLRQQGKEVGETLLYYGCRRSDEDYLYREELAQFHRDGALTQL 551 Query: 627 SVAFSREGPTKEYVQHKMMDKASDIWNMISQGAYLYVCGDAKGMARDVHRSLHTIAQEQG 686 +VAFSRE K YVQH + +W +I GA++YVCGDA+ MARDV + + I E G Sbjct: 552 NVAFSREQSHKVYVQHLLKQDREHLWKLIEGGAHIYVCGDARNMARDVQNTFYDIVAELG 611 Query: 687 SMDSTKAEGFVKNLQTSGRYLRDVW 711 +M+ +A ++K L T GRY DVW Sbjct: 612 AMEHAQAVDYIKKLMTKGRYSLDVW 636 >1TLL-A nrPDB Length = 688 Score = 660 bits (1702), Expect = 0.0, Method: Composition-based stats. Identities = 190/668 (28%), Positives = 305/668 (45%), Gaps = 82/668 (12%) Query: 102 RKKVTIFFGTQTGTAEGFAKALGEEAKARYEKTRFKIVDLDDYAADDDEYE-EKLKKEDV 160 R K TI + T+TG ++ +AK L E K + D A +EY+ L+ E + Sbjct: 11 RVKATILYATETGKSQAYAKTLCEIFKHAF----------DAKAMSMEEYDIVHLEHEAL 60 Query: 161 AFFFLATYGDGEPTDNAARFYKWFTEGN-------------------------------- 188 +T+G+G+P +N +F E Sbjct: 61 VLVVTSTFGNGDPPENGEKFGCALMEMRHPNSVQEERKSYKVRFNSVSSYSDSRKSSGDG 120 Query: 189 -------DRGEWLKNLKYGVFGLGNRQYEHFNKVAKVVDDILVEQGAQRLVQVGLGDDDQ 241 + L N+++ VFGLG+R Y HF VD +L E G +R++++ GD+ Sbjct: 121 PDLRDNFESTGPLANVRFSVFGLGSRAYPHFCAFGHAVDTLLEELGGERILKMREGDELC 180 Query: 242 CIEDDFTAWREALWPELDTILREEGDTAVATPYTAAVLEYRVSIHDSEDAKFNDINMANG 301 E+ F W + ++ + D + P + + R + KF +A Sbjct: 181 GQEEAFRTWAKKVFKAACDVFCVGDDVNIEKPNNSLISNDR----SWKRNKFRLTYVAEA 236 Query: 302 ----NGYTVFDAQHPYKANVAVKRELHTPESDRSCIHLEFDIAGSG-LTYETGDHVGVLC 356 G + + A + ++ L +P+S RS I + G+ L Y+ GDH+GV Sbjct: 237 PDLTQGLSNVHKKRVSAARLLSRQNLQSPKSSRSTIFVRLHTNGNQELQYQPGDHLGVFP 296 Query: 357 DNLSETVDEAL-RLLDMSPDTY---FSLHAEKEDGTPISSSLPPP--FPPCNLRTALTRY 410 N + V+ + RL D P + + E+ + S+ PPC + A Y Sbjct: 297 GNHEDLVNALIERLEDAPPANHVVKVEMLEERNTALGVISNWKDESRLPPCTIFQAFKYY 356 Query: 411 ACLLSSPKKSALVALAAHASDPTEAERLKHLASPAGKDEYSKWVVESQRSLLEVMAEFPS 470 + + P L A+ A++ E +RL L G EY +W +++EV+ EFPS Sbjct: 357 LDITTPPTPLQLQQFASLATNEKEKQRL--LVLSKGLQEYEEWKWGKNPTMVEVLEEFPS 414 Query: 471 AKPPLGVFFAGVAPRLQPRFYSISSSPKIAETRIHVTCALV--YEKMPTGRIHKGVCSTW 528 + P + LQPR+YSISSSP + +H+T A+V + + G +H GVCS+W Sbjct: 415 IQMPATLL-LTQLSLLQPRYYSISSSPDMYPDEVHLTVAIVSYHTRDGEGPVHHGVCSSW 473 Query: 529 MKNAVPYEKSENCSSAPIFVRQS-NFKLPSDSKVPIIMIGPGTGLAPFRGFLQER-LALV 586 + + + P FVR + +F LP + +VP I++GPGTG+APFR F Q+R + Sbjct: 474 LN------RIQADDVVPCFVRGAPSFHLPRNPQVPCILVGPGTGIAPFRSFWQQRQFDIQ 527 Query: 587 ESGVELGPSVLFFGCRNRRMDFIYEEELQRFVESGALAELSVAFSREG-PTKEYVQHKMM 645 G+ P VL FGCR ++D IY EE + G EL A+SRE K+YVQ + Sbjct: 528 HKGMNPCPMVLVFGCRQSKIDHIYREETLQAKNKGVFRELYTAYSREPDRPKKYVQDVLQ 587 Query: 646 DK-ASDIWNMI-SQGAYLYVCGDAKGMARDVHRSLHTIAQEQGSMDSTKAEGFVKNLQTS 703 ++ A ++ + QG ++YVCGD MA DV +++ I +QG + A F+ L+ Sbjct: 588 EQLAESVYRALKEQGGHIYVCGDVT-MAADVLKAIQRIMTQQGKLSEEDAGVFISRLRDD 646 Query: 704 GRYLRDVW 711 RY D++ Sbjct: 647 NRYHEDIF 654 >2BN4-A nrPDB Length = 682 Score = 639 bits (1648), Expect = 0.0, Method: Composition-based stats. Identities = 213/665 (32%), Positives = 326/665 (49%), Gaps = 78/665 (11%) Query: 98 IDDGRKKVTIFFGTQTGTAEGFAKALGEEAKARYEKTRFKIVDLDDYAADDDEYE-EKLK 156 + + K + + +QTGTAE +AK +E A++ +L+ AD + Y+ E L Sbjct: 45 VTENNKNYLVLYASQTGTAEDYAKKFSKELVAKF--------NLNVMCADVENYDFESLN 96 Query: 157 KEDVAF-FFLATYGDGEPTDNAARFYKWFTEGNDRGEWLKNLKYGVFGLGNRQYEHFNKV 215 V F++TYG+G+ D A F + N L NL+Y +FGLGN YE FN Sbjct: 97 DVPVIVSIFISTYGEGDFPDGAVNFEDFIC--NAEAGALSNLRYNMFGLGNSTYEFFNGA 154 Query: 216 AKVVDDILVEQGAQRLVQVGLGDDDQCIED-DFTAWREALWPEL-DTILREEGDTAVATP 273 AK + L GA RL ++G DD D D+ AW++++ L D + +E + + Sbjct: 155 AKKAEKHLSAAGAIRLGKLGEADDGAGTTDEDYMAWKDSILEVLKDELHLDEQEAKFTSQ 214 Query: 274 YTAAVLEYRV--------SIHDSEDAKFNDINMANGNGYTVFDAQHPYKANVAVKRELHT 325 + VL S H + N A+G FD PY A + REL + Sbjct: 215 FQYTVLNEITDSMSLGEPSAHYLPSHQLN--RNADGIQLGPFDLSQPYIAPIVKSRELFS 272 Query: 326 PESDRSCIHLEFDIAGSGLTYETGDHVGVLCDNLSETVDEALRLLDMSPDTYFSLHAEKE 385 +DR+CIH EFD++GS + Y TGDH+ V N E V++ L + ++ P+T F L Sbjct: 273 -SNDRNCIHSEFDLSGSNIKYSTGDHLAVWPSNPLEKVEQFLSIFNLDPETIFDLK---- 327 Query: 386 DGTPISSSLPPPFP-PCNLRTALTRYACLLSSPKKSALVALAAHASDPTEAERLKHLASP 444 P+ ++ PFP P + A+ Y + + +L A + E+L L Sbjct: 328 ---PLDPTVKVPFPTPTTIGAAIKHYLEITGPVSRQLFSSLIQFAPNADVKEKLTLL--S 382 Query: 445 AGKDEYSKWVVESQRSLLEVMAEFPSAKP----PLGVFFAGVAPRLQPRFYSISSSPKIA 500 KD+++ + ++ + + P+ F P++ PR+YSISSS Sbjct: 383 KDKDQFAVEITSKYFNIADALKYLSDGAKWDTVPMQ-FLVESVPQMTPRYYSISSSSLSE 441 Query: 501 ETRIHVTCALVYEKMPTGRIHK-----GVCSTWMKNAVPYEKSENCSSA----------- 544 + +HVT + E P + GV + ++N + + N + Sbjct: 442 KQTVHVTSIV--ENFPNPELPDAPPVVGVTTNLLRNIQLAQNNVNIAETNLPVHYDLNGP 499 Query: 545 ---------PIFVRQSNFKLPSDSKVPIIMIGPGTGLAPFRGFLQERLALVES------G 589 P+ VR+SNF+LPS+ P+IMIGPGTG+APFRGF++ER+A +ES Sbjct: 500 RKLFANYKLPVHVRRSNFRLPSNPSTPVIMIGPGTGVAPFRGFIRERVAFLESQKKGGNN 559 Query: 590 VELGPSVLFFGCRNRRMDFIYEEELQRFVE--SGALAELSVAFSREGPTK-EYVQHKMMD 646 V LG +LF+G RN DF+Y++E + + G+ E+ VA SR TK YVQ K+ D Sbjct: 560 VSLGKHILFYGSRNTD-DFLYQDEWPEYAKKLDGSF-EMVVAHSRLPNTKKVYVQDKLKD 617 Query: 647 KASDIWNMISQGAYLYVCGDAKGMARDVHRSLHTIAQEQGSMDSTKAEGFVKNLQTSGRY 706 ++ MI+ GA++YVCGDAKGMA+ V +L I S+ + +A +K L+TSGRY Sbjct: 618 YEDQVFEMINNGAFIYVCGDAKGMAKGVSTALVGILSRGKSITTDEATELIKMLKTSGRY 677 Query: 707 LRDVW 711 DVW Sbjct: 678 QEDVW 682 >6EFV-A nrPDB Length = 569 Score = 609 bits (1569), Expect = e-174, Method: Composition-based stats. Identities = 178/612 (29%), Positives = 286/612 (46%), Gaps = 85/612 (13%) Query: 104 KVTIFFGTQTGTAEGFAKALGEEAKARYEKTRFKIVDLDDYAADDDEYEEKLKKEDVAFF 163 ++TI +QTG A A+AL ++ A K K+V+ DY +++ E + Sbjct: 39 EITIISASQTGNARRVAEALRDDLLAA--KLNVKLVNAGDYKF------KQIASEKLLIV 90 Query: 164 FLATYGDGEPTDNAARFYKWFTEGNDRGEWLKNLKYGVFGLGNRQYEHFNKVAKVVDDIL 223 +T G+GEP + A +K+ + + L+N + VF LG+ YE F + K D L Sbjct: 91 VTSTQGEGEPPEEAVALHKFLF--SKKAPKLENTAFAVFSLGDSSYEFFCQSGKDFDSKL 148 Query: 224 VEQGAQRLVQVGLGDDDQCIEDDFTAWREALWPELDTILREEGDTAVATPYTAAVLEYRV 283 E G +RL+ R + D Y AA E+R Sbjct: 149 AELGGERLLD-----------------------------RVDADV----EYQAAASEWRA 175 Query: 284 SIHDSEDAKFNDINMANGNGYT--VFDAQHPYKANVAVKRELHTPESDRSCIHLEFDIAG 341 + D+ ++ + N + P A+++V +++ S++ H+E D+ Sbjct: 176 RVVDALKSRAPVVATGAVNEIHTSPYSKDAPLVASLSVNQKITGRNSEKDVRHIEIDLGD 235 Query: 342 SGLTYETGDHVGVLCDNLSETVDEALRLLDMSPDTYFSLHAEKEDGTPISSSLPPPFP-P 400 SGL Y+ GD +GV N V E + LL + D ++ + P++ +L F Sbjct: 236 SGLRYQPGDALGVWYQNDPALVKELVELLWLKGDEPVTVEGKT---LPLNEALQWHFELT 292 Query: 401 CNLRTALTRYACLLSSPKKSALVALAAHASDPTEAERLKHLASPAGKDEYSKWVVESQRS 460 N + YA L S LV A +L+H A+ +V+ Sbjct: 293 VNTANIVENYATLTRSETLLPLVGDKA---------KLQHYAATTP-------IVD---- 332 Query: 461 LLEVMAEFPSAKPPLGVFFAGVAPRLQPRFYSISSSPKIAETRIHVTCALVYEKMPTGRI 520 M F A+ + P L PR YSI+SS E +HVT +V + GR Sbjct: 333 ----MVRFSPAQLDAEALINLLRP-LTPRLYSIASSQAEVENEVHVTVGVVRYDV-EGRA 386 Query: 521 HKGVCSTWMKNAVPYEKSENCSSAPIFVRQS-NFKLPSDSKVPIIMIGPGTGLAPFRGFL 579 G S+++ + V E +F+ + NF+LP++ + P+IMIGPGTG+APFR F+ Sbjct: 387 RAGGASSFLADRV-----EEEGEVRVFIEHNDNFRLPANPETPVIMIGPGTGIAPFRAFM 441 Query: 580 QERLALVESGVELGPSVLFFGCRNRRMDFIYEEELQRFVESGALAELSVAFSREGPTKEY 639 Q+R A G + LFFG + DF+Y+ E QR+V+ G L + +A+SR+ K Y Sbjct: 442 QQRAA----DEAPGKNWLFFGNPHFTEDFLYQVEWQRYVKEGVLTRIDLAWSRDQKEKVY 497 Query: 640 VQHKMMDKASDIWNMISQGAYLYVCGDAKGMARDVHRSLHTIAQEQGSMDSTKAEGFVKN 699 VQ K+ ++ +++W I+ GA++YVCGDA MA+DV ++L + E G MD+ A+ F+ Sbjct: 498 VQDKLREQGAELWRWINDGAHIYVCGDANRMAKDVEQALLEVIAEFGGMDTEAADEFLSE 557 Query: 700 LQTSGRYLRDVW 711 L+ RY RDV+ Sbjct: 558 LRVERRYQRDVY 569 >2B5O-A nrPDB Length = 402 Score = 232 bits (591), Expect = 4e-61, Method: Composition-based stats. Identities = 60/234 (25%), Positives = 110/234 (47%), Gaps = 21/234 (8%) Query: 489 RFYSISSSPK--IAETRIHVTCA--LVYEKMPTGRIHKGVCSTWMKNAVPYEKSENCSSA 544 R YSI+S+ + + + C L Y+ +G GVCST++ N +P + + Sbjct: 179 RLYSIASTRHGDMEDNKTVSLCVRQLEYQDPESGETVYGVCSTYLCN-LPVGTDDVKITG 237 Query: 545 PIFVRQSNFKLPSDSKVPIIMIGPGTGLAPFRGFLQERLALVESGVEL-GPSVLFFGCRN 603 P+ LP D ++M+ GTG+APFR FL + G + L FG Sbjct: 238 PV---GKEMLLPDDEDATVVMLATGTGIAPFRAFLWRMFKEQHEDYKFKGKAWLIFGV-P 293 Query: 604 RRMDFIYEEELQRF-VESGALAELSVAFSREGPT----KEYVQHKMMDKASDIWNMISQ- 657 + +Y+++ ++ E+ L+ A SRE T K YVQ ++ + A +++ MI + Sbjct: 294 YTANILYKDDFEKMAAENPDNFRLTYAISREQKTADGGKVYVQSRVSEYADELFEMIQKP 353 Query: 658 GAYLYVCGDAKGMARDVHRSLHTIAQEQGSMDSTKAEGFVKNLQTSGRYLRDVW 711 ++Y+CG KGM + + A+++G E ++++ R+ +V+ Sbjct: 354 NTHVYMCG-LKGMQPPIDETFTAEAEKRG----LNWEEMRRSMKKEHRWHVEVY 402 Score = 39.4 bits (90), Expect = 0.006, Method: Composition-based stats. Identities = 24/161 (14%), Positives = 47/161 (29%), Gaps = 19/161 (11%) Query: 307 FDAQHPYKANVAVKRELHTPESDRSCIHLEFDIAGSGLTYETGDHVGVL-CDNLSETVDE 365 + + P+ EL + H+ FDI+ L Y G +G++ Sbjct: 117 YRPKTPFLGKCIENYELVDEGGSGTVRHVTFDISEGDLRYLEGQSIGIIPPGEDKNGKPH 176 Query: 366 ALRLLDMSPDTYFSLHAEKEDGTPISS-SLPPPFPPCNLRTALTRYAC----------LL 414 LRL ++ + + K + P + + Y C + Sbjct: 177 KLRLYSIASTRHGDMEDNKTVSLCVRQLEYQDPESGETVYGVCSTYLCNLPVGTDDVKIT 236 Query: 415 SSPKKSALVALAAHASDPTEAERLKHLASPAGKDEYSKWVV 455 K L+ E + LA+ G + ++ Sbjct: 237 GPVGKEMLLPD-------DEDATVVMLATGTGIAPFRAFLW 270 >1B1C-A nrPDB Length = 181 Score = 214 bits (545), Expect = 9e-56, Method: Composition-based stats. Identities = 68/171 (39%), Positives = 97/171 (56%), Gaps = 6/171 (3%) Query: 96 EEIDDGRKKVTIFFGTQTGTAEGFAKALGEEAKARYEKTRFKIVDLDDYAADDDEYEEKL 155 E++ + + +F+G+QTGTAE FA L ++A R D ++Y D ++ Sbjct: 11 EKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHR--YGMRGMSADPEEYDLADLSSLPEI 68 Query: 156 KKEDVAFFFLATYGDGEPTDNAARFYKWFTEGNDRGEWLKNLKYGVFGLGNRQYEHFNKV 215 + F +ATYG+G+PTDNA FY W E + L +K+ VFGLGN+ YEHFN + Sbjct: 69 DN-ALVVFCMATYGEGDPTDNAQDFYDWLQETDVD---LSGVKFAVFGLGNKTYEHFNAM 124 Query: 216 AKVVDDILVEQGAQRLVQVGLGDDDQCIEDDFTAWREALWPELDTILREEG 266 K VD L + GAQR+ ++GLGDDD +E+DF WRE WP + E Sbjct: 125 GKYVDKRLEQLGAQRIFELGLGDDDGNLEEDFITWREQFWPAVCEHFGVEA 175 >3HR4-A nrPDB Length = 219 Score = 162 bits (409), Expect = 5e-40, Method: Composition-based stats. Identities = 46/181 (25%), Positives = 71/181 (39%), Gaps = 12/181 (6%) Query: 97 EIDDGRKKVTIFFGTQTGTAEGFAKALGEEAKARYEKTRFKIVDLDDYAADDDEYEEKLK 156 + R +VTI F T+TG +E A LG + K+V +D Y L+ Sbjct: 35 KTMASRVRVTILFATETGKSEALAWDLGALFSCAF---NPKVVCMDKYRLSC------LE 85 Query: 157 KEDVAFFFLATYGDGEPTDNAARFYKWFTEGNDRGEWLKNLKYGVFGLGNRQYEHFNKVA 216 +E + +T+G+G+ N + K + +Y VFGLG+ Y F A Sbjct: 86 EERLLLVVTSTFGNGDCPGNGEKLKKSLFMLKELNNK---FRYAVFGLGSSMYPRFCAFA 142 Query: 217 KVVDDILVEQGAQRLVQVGLGDDDQCIEDDFTAWREALWPELDTILREEGDTAVATPYTA 276 +D L GA +L +G GD+ ED F +W + G + P Sbjct: 143 HDIDQKLSHLGASQLTPMGEGDELSGQEDAFRSWAVQTFKAACETFDVRGKQHIQIPKLY 202 Query: 277 A 277 Sbjct: 203 T 203 >1BVY-F nrPDB Length = 191 Score = 156 bits (393), Expect = 4e-38, Method: Composition-based stats. Identities = 44/177 (24%), Positives = 84/177 (47%), Gaps = 13/177 (7%) Query: 92 KPREEEIDDGRKKVTIFFGTQTGTAEGFAKALGEEAKARYEKTRFKIVDLDDYAADDDEY 151 K R++ + + + +G+ GTAEG A+ L + A ++ ++ LD +A + Sbjct: 11 KVRKKAENAHNTPLLVLYGSNMGTAEGTARDLADIAMSK--GFAPQVATLDSHAGN---- 64 Query: 152 EEKLKKEDVAFFFLATYGDGEPTDNAARFYKWFTEGNDRGEWLKNLKYGVFGLGNRQY-E 210 L +E A+Y +G P DNA +F W + + + +K ++Y VFG G++ + Sbjct: 65 ---LPREGAVLIVTASY-NGHPPDNAKQFVDWLDQAS--ADEVKGVRYSVFGCGDKNWAT 118 Query: 211 HFNKVAKVVDDILVEQGAQRLVQVGLGDDDQCIEDDFTAWREALWPELDTILREEGD 267 + KV +D+ L +GA+ + G D E + WRE +W ++ + + Sbjct: 119 TYQKVPAFIDETLAAKGAENIADRGEADASDDFEGTYEEWREHMWSDVAAYFNLDIE 175 >4H2D-A nrPDB Length = 165 Score = 148 bits (373), Expect = 8e-36, Method: Composition-based stats. Identities = 51/157 (32%), Positives = 75/157 (47%), Gaps = 10/157 (6%) Query: 104 KVTIFFGTQTGTAEGFAKALGEEAKARYEKTRFKIVDLDDYAADDDEYEEKLKKEDVAFF 163 ++ + FG+QTGTA+ ++ LG EA+ R R + LD Y + L E + F Sbjct: 9 QLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQA--LDSYPVVN------LINEPLVIF 60 Query: 164 FLATYGDGEPTDNAARFYKWFTEGNDRGEWLKNLKYGVFGLGNRQYEHFNKVAKVVDDIL 223 AT G G+P DN F+++ N L + + V GLG+ Y FN VAK + L Sbjct: 61 VCATTGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRL 120 Query: 224 VEQGAQRLVQVGLGDDDQCIEDDFTA--WREALWPEL 258 ++ G L+ V LGDD + D W LW + Sbjct: 121 LQLGGSALLPVCLGDDQHELGPDAAVDPWLRDLWDRV 157 >1YKG-A nrPDB Length = 167 Score = 141 bits (355), Expect = 1e-33, Method: Composition-based stats. Identities = 47/193 (24%), Positives = 77/193 (39%), Gaps = 43/193 (22%) Query: 105 VTIFFGTQTGTAEGFAKALGEEAKARYEKTRFKIVDLDDYAADDDEYEEKLKKEDVAFFF 164 +TI +QTG A A+AL ++ A K K+V+ DY +++ E + Sbjct: 12 ITIISASQTGNARRVAEALRDDLLAA--KLNVKLVNAGDYKF------KQIASEKLLIVV 63 Query: 165 LATYGDGEPTDNAARFYKWFTEGNDRGEWLKNLKYGVFGLGNRQYEHFNKVAKVVDDILV 224 +T G+GEP + A +K+ + + L+N + VF LG+ YE F + K D L Sbjct: 64 TSTQGEGEPPEEAVALHKFLF--SKKAPKLENTAFAVFSLGDTSYEFFCQSGKDFDSKLA 121 Query: 225 EQGAQRLVQVGLGDDDQCIEDDFTAWREALWPELDTILREEGDTAVATPYTAAVLEYRVS 284 E G +RL+ R + D Y AA E+R Sbjct: 122 ELGGERLLD-----------------------------RVDADV----EYQAAASEWRAR 148 Query: 285 IHDSEDAKFNDIN 297 + D+ ++ Sbjct: 149 VVDALKSRAPVAA 161 >2M6S-A nrPDB Length = 149 Score = 124 bits (312), Expect = 9e-29, Method: Composition-based stats. Identities = 40/153 (26%), Positives = 66/153 (43%), Gaps = 15/153 (9%) Query: 104 KVTIFFGTQTGTAEGFAKALGEEAKA-RYEKTRFKIVDLDDYAADDDEYEEKLKKEDVAF 162 ++ IF GT G + A+ A ++ T F+ +L D+ D+Y Sbjct: 3 EIGIFVGTMYGNSLLVAEEAEAILTAQGHKATVFEDPELSDWLPYQDKY---------VL 53 Query: 163 FFLATYGDGEPTDNAARFYKWFTEGNDRGEWLKNLKYGVFGLGNRQYEHFNKVAKVVDDI 222 +T G G+ D+ ++ D + NL+YGV LG+ Y +F K D + Sbjct: 54 VVTSTTGQGDLPDSIVPLFQGI---KDSLGFQPNLRYGVIALGDSSYVNFCNGGKQFDAL 110 Query: 223 LVEQGAQRLVQVGLGDDDQCIEDDFTA--WREA 253 L EQ AQR+ ++ L D + E + + W E Sbjct: 111 LQEQSAQRVGEMLLIDASENPEPETESNPWVEH 143 >5LJI-A nrPDB Length = 148 Score = 103 bits (257), Expect = 2e-22, Method: Composition-based stats. Identities = 39/141 (27%), Positives = 59/141 (41%), Gaps = 16/141 (11%) Query: 107 IFFGTQTGTAEGFAKALGEEAKARYEKTRFKIVDLDDYAADDDEYEEKLKKEDVAFFFLA 166 I F + TG E A + ++ R + + A D + D+A Sbjct: 6 IVFASMTGNTEEIADIVADKL--RDLGLDVDVDECTTVDASD------FLEADIAIVATY 57 Query: 167 TYGDGEPTDNAARFYKWFTEGNDRGEWLKNLKYGVFGLGNRQYEHFNKVAKVVDDILVEQ 226 TYGDGE D FY+ + N G+ YGV G G+ Y+ F K D + V Sbjct: 58 TYGDGELPDEMMDFYEDLADLNLNGKI-----YGVVGSGDTFYDEFCKAVDDFDRVFVST 112 Query: 227 GAQR---LVQVGLGDDDQCIE 244 GA++ V+V L +++ IE Sbjct: 113 GAEKGSECVKVDLSAEEEDIE 133 >2HNA-A nrPDB Length = 147 Score = 80.6 bits (197), Expect = 2e-15, Method: Composition-based stats. Identities = 34/150 (22%), Positives = 61/150 (40%), Gaps = 17/150 (11%) Query: 104 KVTIFFGTQTGTAEGFAKALGEEAK-ARYEKTRFKIVDLDDYAADDDEYEEKLKKEDVAF 162 +T+ G+ G AE A+ L E+ + A + L+D L + Sbjct: 3 DITLISGSTLGGAEYVAEHLAEKLEEAGFTTETLHGPLLED-----------LPASGIWL 51 Query: 163 FFLATYGDGEPTDNAARFYKWFTEGNDRGEWLKNLKYGVFGLGNRQYEHFNKVAKVVDDI 222 +T+G G+ DN + FY+ E L +++G G+G+R+Y+ F ++ Sbjct: 52 VISSTHGAGDIPDNLSPFYEALQEQK---PDLSAVRFGAIGIGSREYDTFCGAIDKLEAE 108 Query: 223 LVEQGAQRLVQVGLGD--DDQCIEDDFTAW 250 L GA++ + + D ED W Sbjct: 109 LKNSGAKQTGETLKINILDHDIPEDPAEEW 138 >4OXX-A nrPDB Length = 162 Score = 79.1 bits (193), Expect = 6e-15, Method: Composition-based stats. Identities = 40/159 (25%), Positives = 60/159 (37%), Gaps = 12/159 (7%) Query: 104 KVTIFFGTQTGTAEGFAKALGEEAKARYEKTRFKIVDLDDYAADDDEYEEKLKKEDVAFF 163 I +GT+TG AE A + + + + D+ A D + + F Sbjct: 2 NALILYGTETGNAEACATTISQVLADTVDTKVHDLADMTPRAMLDSGAD-------LIVF 54 Query: 164 FLATYGDGEPTDNAARFYKWFTEGNDRGEWLKNLKYGVFGLGNRQYEHFNKVAKVVDDIL 223 ATYG+GE A F++ E L L++ VFGLG+ Y FN+ IL Sbjct: 55 ATATYGEGEFAGGGAAFFETLRETK---PDLSGLRFAVFGLGDSYYTTFNQAGATAATIL 111 Query: 224 VEQGAQRLVQVGLGDDDQCIEDDFTA--WREALWPELDT 260 G ++ D + TA W + L T Sbjct: 112 ASLGGTQVGDTARHDTSSGDDPAATAAEWAREILTALAT 150 >5B3K-A nrPDB Length = 150 Score = 77.2 bits (188), Expect = 2e-14, Method: Composition-based stats. Identities = 38/160 (23%), Positives = 56/160 (35%), Gaps = 16/160 (10%) Query: 104 KVTIFFGTQTGTAEGFAKALGEEAKA-RYEKTRFKIVDLDDYAADDDEYEEKLKKEDVAF 162 KV I G+ GTAE A+ + A E + LD+ A E Sbjct: 2 KVAILSGSVYGTAEEVARHAQKLLSAAGLEASHLPRASLDELKAFAPE---------AFL 52 Query: 163 FFLATYGDGEPTDNAARFYKWFTEGNDRGEWLKNLKYGVFGLGNRQY-EHFNKVAKVVDD 221 +T G GE DN Y + L GV GLG+ Y + F + V + Sbjct: 53 VVTSTTGMGELPDNLQPLYYAIRDQ---LPAWHGLPGGVIGLGDSSYGDTFAGGGEQVRE 109 Query: 222 ILVEQGAQRLVQVGLGDDDQCI--EDDFTAWREALWPELD 259 + E G + ++ + D + + E D W L Sbjct: 110 LFGELGVREVLPMLRLDASETVTPETDAEPWLAEFAAALK 149 >5V57-A nrPDB Length = 648 Score = 76.8 bits (187), Expect = 3e-14, Method: Composition-based stats. Identities = 36/161 (22%), Positives = 60/161 (37%), Gaps = 17/161 (10%) Query: 98 IDDGRKKVTIFFGTQTGTAEGFAKALGEE-AKARYEKTRFKIVDLDDYAADDDEYEEKLK 156 I K I +G+ TG E A+ + E A A Y ++D A E + Sbjct: 372 IKSNHAKALIVYGSTTGNTEYTAETIARELADAGY--------EVDSRDAASVEAGGLFE 423 Query: 157 KEDVAFFFLATYGDG--EPTDNAARFYKWFTEGNDRGEWLKNLKYGVFGLGNRQYEHFNK 214 D+ +T+GD E D+ + E +G + FG G+ +E+F Sbjct: 424 GFDLVLLGCSTWGDDSIELQDDFIPLFDSLEETGAQGRKV-----ACFGCGDSSWEYFCG 478 Query: 215 VAKVVDDILVEQGAQRLVQVGLGD-DDQCIEDDFTAWREAL 254 +++ L GA+ + D D + DD W + Sbjct: 479 AVDAIEEKLKNLGAEIVQDGLRIDGDPRAARDDIVGWAHDV 519 >5XRA-A nrPDB Length = 438 Score = 76.8 bits (187), Expect = 3e-14, Method: Composition-based stats. Identities = 37/172 (21%), Positives = 64/172 (37%), Gaps = 17/172 (9%) Query: 104 KVTIFFGTQTGTAEGFAKALGEE-AKARYEKTRFKIVDLDDYAADDDEYEEKLKKEDVAF 162 K I +G+ TG E A+ + E A A Y ++D A E + D+ Sbjct: 210 KALIVYGSTTGNTEYTAETIARELADAGY--------EVDSRDAASVEAGGLFEGFDLVL 261 Query: 163 FFLATYGDG--EPTDNAARFYKWFTEGNDRGEWLKNLKYGVFGLGNRQYEHFNKVAKVVD 220 +T+GD E D+ + E +G + FG G+ +E+F ++ Sbjct: 262 LGCSTWGDDSIELQDDFIPLFDSLEETGAQGRKV-----ACFGCGDSSWEYFCGAVDAIE 316 Query: 221 DILVEQGAQRLVQVGLGD-DDQCIEDDFTAWREALWPELDTILREEGDTAVA 271 + L GA+ + D D + DD W + + R + + A Sbjct: 317 EKLKNLGAEIVQDGLRIDGDPRAARDDIVGWAHDVRGAIPDQARMDIELAKT 368 >5ZKP-A nrPDB Length = 466 Score = 76.4 bits (186), Expect = 4e-14, Method: Composition-based stats. Identities = 36/166 (21%), Positives = 63/166 (37%), Gaps = 17/166 (10%) Query: 104 KVTIFFGTQTGTAEGFAKALGEE-AKARYEKTRFKIVDLDDYAADDDEYEEKLKKEDVAF 162 K I +G+ TG E A+ + E A A Y ++D A E + D+ Sbjct: 220 KALIVYGSTTGNTEYTAETIARELADAGY--------EVDSRDAASVEAGGLFEGFDLVL 271 Query: 163 FFLATYGDG--EPTDNAARFYKWFTEGNDRGEWLKNLKYGVFGLGNRQYEHFNKVAKVVD 220 +T+GD E D+ + E +G + FG G+ +E+F ++ Sbjct: 272 LGCSTWGDDSIELQDDFIPLFDSLEETGAQGRKV-----ACFGCGDSSWEYFCGAVDAIE 326 Query: 221 DILVEQGAQRLVQVGLGD-DDQCIEDDFTAWREALWPELDTILREE 265 + L GA+ + D D + DD W + + + R + Sbjct: 327 EKLKNLGAEIVQDGLRIDGDPRAARDDIVGWAHDVRGAIAEVKRRD 372 >6GAQ-A nrPDB Length = 154 Score = 76.0 bits (185), Expect = 5e-14, Method: Composition-based stats. Identities = 33/143 (23%), Positives = 60/143 (41%), Gaps = 13/143 (9%) Query: 104 KVTIFFGTQTGTAEGFAKALGEEAKARYEKTRFKIVDLDDYAADDDEYEEKLKKEDVAFF 163 K+ I + + +G E A L + + ++ + +++ A E+L D Sbjct: 10 KILIAYASMSGNTESIA-DLIKVSLDAFDHEVV-LQEMEGMDA------EELLAYDGIIL 61 Query: 164 FLATYGDGEPTDNAARFYKWFTEGNDRGEWLKNLKYGVFGLGNRQYEHFNKVAKVVDDIL 223 T+GDGE A F+ + L K VFG G+ YE F + + ++ L Sbjct: 62 GSYTWGDGELPFEAEDFHDDLENID-----LAGKKVAVFGSGDTAYELFCEAVTIFEERL 116 Query: 224 VEQGAQRLVQVGLGDDDQCIEDD 246 VE+GA+ + + + E+D Sbjct: 117 VERGAELVQEGLKIELAPEDEED 139 >4HEQ-A nrPDB Length = 146 Score = 74.1 bits (180), Expect = 2e-13, Method: Composition-based stats. Identities = 31/157 (19%), Positives = 57/157 (36%), Gaps = 15/157 (9%) Query: 104 KVTIFFGTQTGTAEGFAKALGEEAKARYEKTRFKIVDLDDYAADDDEYEEKLKKEDVAFF 163 K I +G+ TG EG A+A+ + + +T V + Y+ V Sbjct: 3 KALIVYGSTTGNTEGVAEAIAKTLNSEGMETTVVNVADVTAPGLAEGYD-------VVLL 55 Query: 164 FLATYGDGE--PTDNAARFYKWFTEGNDRGEWLKNLKYGVFGLGNRQYEHFNKVAKVVDD 221 +T+GD E ++ Y+ + + + GVFG G+ Y +F V++ Sbjct: 56 GCSTWGDDEIELQEDFVPLYEDLDRAGLKDKKV-----GVFGCGDSSYTYFCGAVDVIEK 110 Query: 222 ILVEQGAQRLVQVGLGDDDQCIEDDFTAWREALWPEL 258 E GA + D + + W + + Sbjct: 111 KAEELGATLVASSLKIDGEPDSAE-VLDWAREVLARV 146 >5YOB-A nrPDB Length = 148 Score = 73.7 bits (179), Expect = 2e-13, Method: Composition-based stats. Identities = 35/155 (22%), Positives = 59/155 (38%), Gaps = 17/155 (10%) Query: 104 KVTIFFGTQTGTAEGFAKALGEE-AKARYEKTRFKIVDLDDYAADDDEYEEKLKKEDVAF 162 K I +G+ TG E A+ + E A A Y ++D A E + D+ Sbjct: 3 KALIVYGSTTGNTEYTAETIARELADAGY--------EVDSRDAASVEAGGLFEGFDLVL 54 Query: 163 FFLATYGDG--EPTDNAARFYKWFTEGNDRGEWLKNLKYGVFGLGNRQYEHFNKVAKVVD 220 +T+GD E D+ + E +G + FG G+ +E+F ++ Sbjct: 55 LGCSTWGDDSIELQDDFIPLFDSLEETGAQGRKV-----ACFGCGDSSWEYFCGAVDAIE 109 Query: 221 DILVEQGAQRLVQVGLGD-DDQCIEDDFTAWREAL 254 + L GA+ + D D + DD W + Sbjct: 110 EKLKNLGAEIVQDGLRIDGDPRAARDDIVGWAHDV 144 >5VEG-A nrPDB Length = 178 Score = 71.8 bits (174), Expect = 9e-13, Method: Composition-based stats. Identities = 30/140 (21%), Positives = 51/140 (36%), Gaps = 14/140 (10%) Query: 107 IFFGTQTGTAEGFAKALGEEAKARYEKTRFKIVDLDDYAADDDEYEEKLKKEDVAFFFLA 166 + + T TG E A + + K+ + + D ++ + D+ Sbjct: 35 VVYATMTGNNEEVANIVCDSL----TNLNVKVTESEISQTDVADFMKA----DILVVCAY 86 Query: 167 TYGDGEPTDNAARFYKWFTEGNDRGEWLKNLKYGVFGLGNRQY-EHFNKVAKVVDDILVE 225 TY +G + FY + G+ YGV G G++ Y E+FN DD + Sbjct: 87 TYDEGAMPEEGLDFYDDLQSTDLTGKV-----YGVAGSGDKFYGEYFNTTVDHFDDAFKK 141 Query: 226 QGAQRLVQVGLGDDDQCIED 245 GA + D + ED Sbjct: 142 AGATSGAEKVKIDLEPYEED 161 >6FSI-A nrPDB Length = 147 Score = 64.1 bits (154), Expect = 2e-10, Method: Composition-based stats. Identities = 30/144 (20%), Positives = 56/144 (38%), Gaps = 15/144 (10%) Query: 104 KVTIFFGTQTGTAEGFAKALGEEAKARYEKTRFKIVDLDDYAADDDEYEEKLKKEDVAFF 163 K+ + F + +G E A + R +++ D L++ D Sbjct: 2 KLVMIFASMSGNTEEMADHIA-------GVIRETENEIEVIDIMDSPEASILEQYDGIIL 54 Query: 164 FLATYGDGEPTDNAARFYKWFTEGNDRGEWLKNLKYGVFGLGNRQYEHFNKVAKVVDDIL 223 T+GDG+ D+ FY + L K VFG + Y + ++ + L Sbjct: 55 GAYTWGDGDLPDDFLDFYDAMDSID-----LTGKKAAVFGSCDSAYPKYGVAVDILIEKL 109 Query: 224 VEQGAQRL---VQVGLGDDDQCIE 244 E+GA + ++V L +D+ +E Sbjct: 110 QERGAAVVLEGLKVELTPEDEDVE 133 >3F6S-A nrPDB Length = 148 Score = 62.5 bits (150), Expect = 6e-10, Method: Composition-based stats. Identities = 36/157 (22%), Positives = 60/157 (38%), Gaps = 13/157 (8%) Query: 104 KVTIFFGTQTGTAEGFAKALGEEAKARYEKTRFKIVDLDDYAADDDEYEEKLKKEDVAFF 163 KV I FG+ TG E A+ L E A +++ D +A++ D F Sbjct: 3 KVLIVFGSSTGNTESIAQKLEELIAAG--GHEVTLLNAADASAENLA-----DGYDAVLF 55 Query: 164 FLATYGDGEPTDNAARFYKWFTEGNDRGEWLKNLKYGVFGLGNRQYEHFNKVAKVVDDIL 223 + +G + + E DR L K F G+++YEHF +++ Sbjct: 56 GCSAWGMEDL--EMQDDFLSLFEEFDRIG-LAGRKVAAFASGDQEYEHFCGAVPAIEERA 112 Query: 224 VEQGAQRLVQ--VGLGDDDQCIEDDFTAWREALWPEL 258 E GA + + GD E ++ E + +L Sbjct: 113 KELGATIIAEGLKMEGDASNDPE-AVASFAEDVLKQL 148 >3KAQ-A nrPDB Length = 147 Score = 58.7 bits (140), Expect = 9e-09, Method: Composition-based stats. Identities = 35/159 (22%), Positives = 62/159 (38%), Gaps = 17/159 (10%) Query: 104 KVTIFFGTQTGTAEGFAKALGEEAKARYEKTRFKIVDLDDYAADDDEYEEKLKKEDVAFF 163 KV I FG+ TG E A+ L E A +++ + +AD+ D Sbjct: 2 KVLILFGSSTGNTESIAQKLEELVAAG--GHEVTLLNAAEASADNLA-----DGYDAVLM 54 Query: 164 FLATYG--DGEPTDNAARFYKWFTEGNDRGEWLKNLKYGVFGLGNRQYEHFNKVAKVVDD 221 + +G D E D+ A + +G+ L F G+ +YEH+ +++ Sbjct: 55 GCSAWGMEDLELQDDFAPLFDEMENMGLKGKKL-----AAFASGDMEYEHYCGAVPAIEE 109 Query: 222 ILVEQGAQRLVQ--VGLGDDDQCIEDDFTAWREALWPEL 258 GA+ + + GD D +A+ E + +L Sbjct: 110 KARGLGAEVICEGLKIEGDASSD-PDAVSAFAEDVLKKL 147 >1KRH-A nrPDB Length = 338 Score = 54.8 bits (130), Expect = 1e-07, Method: Composition-based stats. Identities = 52/254 (20%), Positives = 88/254 (34%), Gaps = 37/254 (14%) Query: 417 PKKSALVALAAHASDPTEAERLKHLASPAGKDEYSKWVVESQRSLLEVMAEFPSAKPPLG 476 P A+ + AS ++ H + E + L+ P G Sbjct: 87 PTSDAVFQIQ--ASSEVCKTKIHHFEGTLARVENLSDSTITFDIQLDDGQ--PDIHFLAG 142 Query: 477 VFFAGVAPRLQ-PRFYSISSSPKIAETRIHVTCALVYEKMPTGRIHKGVCSTWMKNAVPY 535 + P R YS SS P + V +P G++ S ++ Sbjct: 143 QYVNVTLPGTTETRSYSFSSQPG------NRLTGFVVRNVPQGKM-----SEYLSVQAKA 191 Query: 536 EKSENCSSAPIFVRQSNFKLPSDSKVPIIMIGPGTGLAPFRGFLQERLALVESGVELGPS 595 + + P +F L D K P++M+ GTG+APF LQ ++E P Sbjct: 192 G-DKMSFTGPF----GSFYL-RDVKRPVLMLAGGTGIAPFLSMLQ----VLEQKGSEHPV 241 Query: 596 VLFFGCRNRRMDFIYEEELQRFVESGALAE--LSVAFSREGPTKE-YVQHKMMDKASDIW 652 L FG D + E+L + E VA + ++ YV + + Sbjct: 242 RLVFGVTQ-DCDLVALEQLDALQQKLPWFEYRTVVAHAESQHERKGYVTGHIE------Y 294 Query: 653 NMISQG-AYLYVCG 665 + ++ G +Y+CG Sbjct: 295 DWLNGGEVDVYLCG 308 >3OZU-A nrPDB Length = 403 Score = 50.2 bits (118), Expect = 3e-06, Method: Composition-based stats. Identities = 49/222 (22%), Positives = 79/222 (35%), Gaps = 27/222 (12%) Query: 465 MAEFPSAKPPLGVFFAGVAPRLQPRFYSISSSPKIAETRIHVTCALVYEKMPTGRIHKGV 524 + F + Q R YS+S P RI V ++ G G Sbjct: 182 VVNFEPGQYTSVAIDVPALGLQQIRQYSLSDMPNGRSYRISV------KREGGGPQPPGY 235 Query: 525 CSTWMKNAVPYEKSENCSSAPIFVRQSNFKLPSDSKVPIIMIGPGTGLAPFRGFLQERLA 584 S + + V + +AP +F + D+K PI++I G GL P L ++A Sbjct: 236 VSNLLHDHVNVG-DQVKLAAP----YGSFHIDVDAKTPIVLISGGVGLTPMVSML--KVA 288 Query: 585 LVESGVELGPSVLFFGCRNRRMDFIYEEELQRFVESGALAELSVAFSREGPTKEYVQHKM 644 L V G RN + + L+ ++ +L V + + P E VQ + Sbjct: 289 LQAP---PRQVVFVHGARNSAV-HAMRDRLREAAKTYENLDLFVFY--DQPLPEDVQGRD 342 Query: 645 MDKASDI-WNMISQG-----AYLYVCGDA--KGMARDVHRSL 678 D + I + A Y+CG M D ++L Sbjct: 343 YDYPGLVDVKQIEKSILLPDADYYICGPIPFMRMQHDALKNL 384 >5OGX-A nrPDB Length = 336 Score = 49.8 bits (117), Expect = 4e-06, Method: Composition-based stats. Identities = 44/232 (18%), Positives = 75/232 (32%), Gaps = 32/232 (13%) Query: 411 ACLLSSPKKSALVALAAHASDPTEAERLKHLASPAGKDEYSKWVVESQRSLLEVMAEFPS 470 L + A + + A L+ L + + R +L +AE Sbjct: 73 LALACQARPLADTEVRSTADAGRVTHPLRDLTATV---LEVADIARDTRRVLLGLAE--P 127 Query: 471 AKPPLGVFFAGVAPRLQPR-FYSISSSPKIAET-RIHVTCALVYEKMPTGRIHKGVCST- 527 G + V P R YS++++ + +HV R+ GV + Sbjct: 128 LAFEAGQYVELVVPGSGARRQYSLANTADEDKVLELHVR-----------RVPGGVATDG 176 Query: 528 WMKNAVPYEKSENCSSAPIFVRQSNFKLP---SDSKVPIIMIGPGTGLAPFRGFLQERLA 584 W+ + + ++ P+ +F LP D P+++IG GTGLAP G + Sbjct: 177 WLFDGLAAG-DRVEATGPL----GDFHLPPPDEDDGGPMVLIGGGTGLAPLVG-IARTAL 230 Query: 585 LVESGVELGPSVLFFGCRNRRMDFIYEEELQRFVESGALAELSVAFSREGPT 636 E+ +L+ G R D E S E Sbjct: 231 ARHPSREV---LLYHGVRGA-ADLYDLGRFAEIAEEHPGFRFVPVLSDEPDP 278 >2FCR-A nrPDB Length = 173 Score = 49.0 bits (115), Expect = 7e-06, Method: Composition-based stats. Identities = 37/146 (25%), Positives = 60/146 (41%), Gaps = 15/146 (10%) Query: 104 KVTIFFGTQTGTAEGFAKALGEEAKARYEKTRFKIVDLDDYAADDDEYEEKLKKEDVAFF 163 K+ IFF T TG A +G+ A+ + DD + LK D+ F Sbjct: 1 KIGIFFSTSTGNTTEVADFIGKTLGAKADAPI---------DVDDVTDPQALKDYDLLFL 51 Query: 164 FLATYGDGEPTDNAARFYKWFTEGNDRGEWLKNLKYGVFGLGNRQ-YE-HFNKVAKVVDD 221 T+ G T+ + + F +K+L +FGLG+ + Y +F + + D Sbjct: 52 GAPTWNTGADTERSGTSWDEFLYDKLPEVDMKDLPVAIFGLGDAEGYPDNFCDAIEEIHD 111 Query: 222 ILVEQGAQRLVQVGLGD-DDQCIEDD 246 +QGA+ VG + DD E+ Sbjct: 112 CFAKQGAK---PVGFSNPDDYDYEES 134 >1CZN-A nrPDB Length = 169 Score = 48.3 bits (113), Expect = 1e-05, Method: Composition-based stats. Identities = 24/131 (18%), Positives = 51/131 (38%), Gaps = 16/131 (12%) Query: 104 KVTIFFGTQTGTAEGFAKALGEEAKARYEKTRFKIVDLDDYAADDDEYEEKLKKEDVAFF 163 K+ +F+GTQTG + A+++ +E I + D + +Y Sbjct: 2 KIGLFYGTQTGVTQTIAESIQQEFGGESIVDLNDIANADASDLNAYDY---------LII 52 Query: 164 FLATYGDGEPTDNAARFYKWFTEGNDRGEWLKNLKYGVFGLGNR--QYEHFNKVAKVVDD 221 T+ GE + Y N +G+ + FG G++ ++F ++++ Sbjct: 53 GCPTWNVGELQSDWEGIYDDLDSVNFQGKKV-----AYFGAGDQVGYSDNFQDAMGILEE 107 Query: 222 ILVEQGAQRLV 232 + G+Q + Sbjct: 108 KISSLGSQTVG 118 >2V5U-A nrPDB Length = 169 Score = 47.9 bits (112), Expect = 2e-05, Method: Composition-based stats. Identities = 26/136 (19%), Positives = 58/136 (42%), Gaps = 25/136 (18%) Query: 103 KKVTIFFGTQTGTAEGFAKALGEEA----KARYEKTRFKIVDLDDYAADDDEYEEKLKKE 158 KK+ +F+GTQTG E A+ + +E ++ ++ ++ DL+DY Sbjct: 2 KKIGLFYGTQTGKTESVAEIIRDEFGNDVVTLHDVSQAEVTDLNDYQY------------ 49 Query: 159 DVAFFFLATYGDGEPTDNAARFYKWFTEGNDRGEWLKNLKYGVFGLGNRQ-Y-EHFNKVA 216 T+ GE + Y + + G+ + FG G++ Y ++F Sbjct: 50 --LIIGCPTWNIGELQSDWEGLYSELDDVDFNGKLV-----AYFGTGDQAGYADNFQDAI 102 Query: 217 KVVDDILVEQGAQRLV 232 ++++ + ++G + + Sbjct: 103 GILEEKISQRGGKTVG 118 >4EH1-A nrPDB Length = 243 Score = 47.5 bits (111), Expect = 2e-05, Method: Composition-based stats. Identities = 39/190 (20%), Positives = 76/190 (40%), Gaps = 23/190 (12%) Query: 489 RFYSISSSPKIAETRIHVTCALVYEKMPTGRIHKGVCSTWMKNAVPYEKSENCSSAPIFV 548 R YS+S + E RI V ++ G + G+ S ++ N V S ++ Sbjct: 55 RQYSLSHASNGREYRISV------KREGVGSDNPGLVSHYLHNNVKVG-----DSVKLYA 103 Query: 549 RQSNFKLPSDSKVPIIMIGPGTGLAPFRGFLQERLALVESGVELGPSVLFFGCRNRRMDF 608 +F + P+++I G G P + L +SGV + C + + Sbjct: 104 PAGDFFYVERER-PVVLISAGVGATPMQAILHTLAKQNKSGVTY-----LYACNSAKEHT 157 Query: 609 IYEEELQRFVESGALAELSVAFSREGPTKEYVQHKMMDKASDIWNMISQGAYLYVCGDAK 668 +E Q + G + ++ + R+ + +Q +M + +++ I G + Y+CG Sbjct: 158 FAQETAQLIAQQGWMQQV---WYRDESADDVLQGEM--QLAELILPIEDGDF-YLCGPIG 211 Query: 669 GMARDVHRSL 678 M V + L Sbjct: 212 FMQYVVKQLL 221 >2WC1-A nrPDB Length = 182 Score = 44.8 bits (104), Expect = 1e-04, Method: Composition-based stats. Identities = 30/158 (18%), Positives = 56/158 (35%), Gaps = 27/158 (17%) Query: 104 KVTIFFGTQTGTAEGFAKALGEEA--KARYEKTRFKIVDLDDYAADDDEYEEKLKKEDVA 161 K+ +FFG+ TGT AK + + + + D+ D+ A D Sbjct: 3 KIGLFFGSDTGTTRKIAKQIKDMFDDEVMAKPLNVNRADVADFMAY-----------DFL 51 Query: 162 FFFLATYGDGEPTD-----NAARFYKWFTEGNDRGEWLKNLKYGVFGLGNR-QYE-HFNK 214 T GDG+ + + ++ D+ +FGLG++ Y F Sbjct: 52 ILGTPTLGDGQLPGLSANAASESWEEFLPRIADQ--DFSGKTIALFGLGDQVTYPLEFVN 109 Query: 215 VAKVVDDILVEQGAQRLVQ-----VGLGDDDQCIEDDF 247 + + ++GA + + G D +E +F Sbjct: 110 ALFFLHEFFSDRGANVVGRWPAKGYGFEDSLAVVEGEF 147 >3W2G-A nrPDB Length = 271 Score = 44.4 bits (103), Expect = 2e-04, Method: Composition-based stats. Identities = 37/198 (18%), Positives = 61/198 (30%), Gaps = 23/198 (11%) Query: 471 AKPPLGVFFAGVA---PRLQPRFYSISSSPKIAETRIHVTCALVYEKMPTGRIHKGV-CS 526 P+G A L R Y+ SS + VY K + G S Sbjct: 41 LGLPVGQHIYLSARIDGNLVIRPYTPVSSDD--DKGFVDLVIKVYFKDTHPKFPAGGKMS 98 Query: 527 TWMKNAVPYEKSENCSSAPIFVRQSNFKL---PSDSKVPII-------MIGPGTGLAPFR 576 ++++ + E + V Q K P P+I MI GTG+ P Sbjct: 99 QYLESMKIGDTIEFRGPNGLLVYQGKGKFAIRPDKKSSPVIKTVKSVGMIAGGTGITPML 158 Query: 577 GFLQERLALVESGVELGPSVLFFGCRNRRMDFIYEEELQRFVES-GALAELSVAFSREGP 635 + R + + +LF D + EL+ A +L R Sbjct: 159 QVI--RAIMKDPDDHTVCHLLF--ANQTEKDILLRPELEELRNEHSARFKLWYTVDRAPE 214 Query: 636 TKEYVQHKMMDK--ASDI 651 +Y Q + ++ + Sbjct: 215 AWDYSQGFVNEEMIRDHL 232 >1YOB-A nrPDB Length = 179 Score = 44.4 bits (103), Expect = 2e-04, Method: Composition-based stats. Identities = 33/184 (17%), Positives = 56/184 (30%), Gaps = 41/184 (22%) Query: 104 KVTIFFGTQTGTAEGFAKALGEEAKARYEKTRFKIVDLDDYAADDDEYEEKLKKEDVAFF 163 K+ +FFG+ TG AK++ + RF + D + E + Sbjct: 2 KIGLFFGSNTGKTRKVAKSIKK---------RFDDETMSDALNVNRVSAEDFAQYQFLIL 52 Query: 164 FLATYGDGEPTD-----NAARFYKWFTEGNDRGEWLKNLKYGVFGLGNRQ---------- 208 T G+GE + ++ G +FGLG++ Sbjct: 53 GTPTLGEGELPGLSSDAENESWEEFL--PKIEGLDFSGKTVALFGLGDQVGYPENYLDAL 110 Query: 209 ---YEHFNKVAKVVDDILVEQG-----AQRLVQ---VGLGDDDQCI----EDDFTAWREA 253 Y F + G ++ +V VGL D ++ AW Sbjct: 111 GELYSFFKDRGAKIVGSWSTDGYEFESSEAVVDGKFVGLALDLDNQSGKTDERVAAWLAQ 170 Query: 254 LWPE 257 + PE Sbjct: 171 IAPE 174 >1UMK-A nrPDB Length = 275 Score = 44.0 bits (102), Expect = 2e-04, Method: Composition-based stats. Identities = 38/198 (19%), Positives = 62/198 (31%), Gaps = 23/198 (11%) Query: 471 AKPPLGVFFAGVA---PRLQPRFYSISSSPKIAETRIHVTCALVYEKMPTGRIHKGV-CS 526 P+G A L R Y+ SS + VY K + G S Sbjct: 45 LGLPVGQHIYLSARIDGNLVVRPYTPISSDD--DKGFVDLVIKVYFKDTHPKFPAGGKMS 102 Query: 527 TWMKNAVPYEKSENCSSAPIFVRQSNFKL---PSDSKVPII-------MIGPGTGLAPFR 576 ++++ + E + + V Q K P PII MI GTG+ P Sbjct: 103 QYLESMQIGDTIEFRGPSGLLVYQGKGKFAIRPDKKSNPIIRTVKSVGMIAGGTGITPML 162 Query: 577 GFLQERLALVESGVELGPSVLFFGCRNRRMDFIYEEELQRFVES-GALAELSVAFSREGP 635 + R + + +LF D + EL+ A +L R Sbjct: 163 QVI--RAIMKDPDDHTVCHLLF--ANQTEKDILLRPELEELRNKHSARFKLWYTLDRAPE 218 Query: 636 TKEYVQHKMMDK--ASDI 651 +Y Q + ++ + Sbjct: 219 AWDYGQGFVNEEMIRDHL 236 >2R6H-A nrPDB Length = 290 Score = 42.9 bits (99), Expect = 5e-04, Method: Composition-based stats. Identities = 31/157 (19%), Positives = 62/157 (39%), Gaps = 20/157 (12%) Query: 487 QPRFYSISSSPKIAETRIHVTCALVYEKMPTGRIHK-------GVCSTWMKNAVPYEKSE 539 R YS+++ P AE I + +K G+ S+++ + P + Sbjct: 85 TVRAYSMANYP--AEGNIITLNVRIATPPFDRAANKWKAGIKPGISSSYIFSLKPG--DK 140 Query: 540 NCSSAPIFVRQSNFKLPSDSKVPIIMIGPGTGLAPFRGFLQERLALVESGVELGPSVLFF 599 S P +F + D+ ++ IG G G+AP R + +++G ++ ++ Sbjct: 141 VMMSGP----YGDFHI-QDTDAEMLYIGGGAGMAPLRAQILHLFRTLKTGRKVS---YWY 192 Query: 600 GCRNRRMDFIYEEELQRFVESGALAELSVAFSREGPT 636 G R + + YEE+ + + +A S P Sbjct: 193 GAR-SKNEIFYEEDFREIEREFPNFKFHIALSDPQPE 228 >5THX-A nrPDB Length = 266 Score = 41.7 bits (96), Expect = 0.001, Method: Composition-based stats. Identities = 32/182 (17%), Positives = 62/182 (34%), Gaps = 40/182 (21%) Query: 467 EFPSAKPPLGVFFAGVAPRLQPRFYSISSSPKIAETRIHVTCALVYEKMPTGRIHK-GVC 525 F + + + A P + R YS++S+ E + V + T R+ V Sbjct: 39 RFENGQFVMVGLMADGKPLM--RAYSVASAN--WEEHLEFFSIKVQDGPLTSRLQHLKVG 94 Query: 526 STWMKNAVPYEKSENCSSAPIFVRQSNFKLPSDSKVPIIMIGPGTGLAPFRGFLQERLAL 585 + + P C + + ++ GTG+APF ++ Sbjct: 95 DEVLISKKPTGTLVACDL--------------NPGKHLYLLSTGTGIAPFLSITKD---- 136 Query: 586 VESGVELGPSVLFFGCRNRRMDFIYEEELQRFVESGALAELSVAFSREGPTKEYVQHKMM 645 E + +L G R Y+++L + F++E P EY+ + Sbjct: 137 PEIYEQFEKIILVHGVR-------YKKDLAYYDR----------FTKELPEHEYLGDLVK 179 Query: 646 DK 647 +K Sbjct: 180 EK 181 >4B4D-A nrPDB Length = 262 Score = 41.7 bits (96), Expect = 0.001, Method: Composition-based stats. Identities = 29/183 (15%), Positives = 64/183 (34%), Gaps = 29/183 (15%) Query: 440 HLASPAGKDEYSK---WVVESQRSLL---EVMAEFPSAKPPLGVFFAGVAPRLQPRFYSI 493 H++S G + + W ++ S + F + + + P L R YSI Sbjct: 3 HMSSAFGAETVLEVRHW-TDAYFSFTTTRDAGFRFENGQFVMIGLETETRPLL--RAYSI 59 Query: 494 SSSPKIAETRIHVTCALVYEKMPTGRIHKGVCSTWMKNAVPYEKSENCSSAPIFVRQSNF 553 +S+ + + + ++ G ++ +++ P + + Sbjct: 60 ASANWEE-----------HLEFFSIKVPDGPLTSRLQHIQP----GDKVLVGKKPTGTLL 104 Query: 554 KLPSDSKVPIIMIGPGTGLAPFRGFLQERLALVESGVELGPSVLFFGCRNRRMDFIYEEE 613 + ++G GTGLAP+ +++ E+ +L G R D Y + Sbjct: 105 ISDLHPGRNLYLLGTGTGLAPWLSIIKD----PETYERFDKVILTQGVR-FVQDLAYRDY 159 Query: 614 LQR 616 +R Sbjct: 160 FER 162 >1AG9-A nrPDB Length = 175 Score = 41.3 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 36/149 (24%), Positives = 61/149 (40%), Gaps = 28/149 (18%) Query: 106 TIFFGTQTGTAEGFAKALGEEAKARYEKTRFKIVDLDDYAADDDEYEEKLKKEDVAFFFL 165 IFFG+ TG E AK + ++ + D+ D A +E L+ D+ + Sbjct: 4 GIFFGSDTGNTENIAKMIQKQL-------GKDVADVHDIA---KSSKEDLEAYDILLLGI 53 Query: 166 ATYGDGEPTDNAARFYKWFTEGNDRGEWLKNLKYGVFGLGNRQ-Y-EHFNKVAKVVDDIL 223 T+ GE + F+ E + G+ + +FG G+++ Y E+F + DI+ Sbjct: 54 PTWYYGEAQCDWDDFFPTLEEIDFNGKLV-----ALFGCGDQEDYAEYFCDALGTIRDII 108 Query: 224 VEQGAQRLV-----------QVGLGDDDQ 241 +GA + GL DDD Sbjct: 109 EPRGATIVGHWPTAGYHFEASKGLADDDH 137 >2BMV-A nrPDB Length = 164 Score = 40.6 bits (93), Expect = 0.003, Method: Composition-based stats. Identities = 32/174 (18%), Positives = 57/174 (32%), Gaps = 40/174 (22%) Query: 104 KVTIFFGTQTGTAEGFAKALGEEAKARYEKTRFKIVDLDDYAADDDEYEEKLKKEDVAFF 163 K+ IFFGT +G AE A+ + + ++VD+ +E+ Sbjct: 3 KIGIFFGTDSGNAEAIAEKISK------AIGNAEVVDVAK------ASKEQFNSFTKVIL 50 Query: 164 FLATYGDGEPTDNAARFYKWFTEGNDRGEWLKNLKYGVFGLGNR-QY-EHFNKV------ 215 T G G+ + F G N G+ GLG++ Y E F + Sbjct: 51 VAPTAGAGDLQTDWEDFL-----GTLEASDFANKTIGLVGLGDQDTYSETFAEGIFHIYE 105 Query: 216 --------------AKVVDDILVEQGAQRLVQVGLGDDDQCIEDDFTA-WREAL 254 + +G + + V D+ + D+ + W E + Sbjct: 106 KAKAGKVVGQTSTDGYHFEASKAVEGGKFVGLVIDEDNQDDLTDERISKWVEQV 159 >1A8P-A nrPDB Length = 258 Score = 37.5 bits (85), Expect = 0.020, Method: Composition-based stats. Identities = 26/140 (18%), Positives = 48/140 (34%), Gaps = 21/140 (15%) Query: 467 EFPSAKPPLGVFFAGVAPRLQPRFYSISSSPKIAETRIHVTCALVYEKMPTGRIHKGVCS 526 F + + + P + R YSI+S + + + ++ G + Sbjct: 31 RFENGQFVMIGLEVDGRPLM--RAYSIASPNYEE-----------HLEFFSIKVQNGPLT 77 Query: 527 TWMKNAVPYEKSENCSSAPIFVRQSNFKLPSDSKVPIIMIGPGTGLAPFRGFLQERLALV 586 + +++ + S P ++ LP + M+ GTGLAPF +Q+ Sbjct: 78 SRLQH-LKEGDELMVSRKPTGTLVTSDLLPGKH---LYMLSTGTGLAPFMSLIQD----P 129 Query: 587 ESGVELGPSVLFFGCRNRRM 606 E VL G R Sbjct: 130 EVYERFEKVVLIHGVRQVNE 149 >4G1B-A nrPDB Length = 399 Score = 37.5 bits (85), Expect = 0.020, Method: Composition-based stats. Identities = 37/184 (20%), Positives = 67/184 (36%), Gaps = 20/184 (10%) Query: 489 RFYSISSSPKIAETRIHVTCALVYEKMPTGRIHKGVCSTWMKNAVPYEKSENCSSAPIFV 548 R YS+ S+ R V E P G+ S ++ E SAP Sbjct: 207 RHYSLCSASTKNGLRFAVKMEAARENFPA-----GLVSEYLHKDAKVG-DEIKLSAPAGD 260 Query: 549 RQSNFKLPSDSKVPIIMIGPGTGLAPFRGFLQERLALVESGVELGPSVLFFGCRNRRMDF 608 N +L ++VP++++ G G+ P L+E+ V+ P+ + ++ Sbjct: 261 FAINKELIHQNEVPLVLLSSGVGVTPLLAMLEEQ-------VKCNPNRPIYWIQSS---- 309 Query: 609 IYEEELQRFVESGALAELSVAFSREGPTKEYVQHKMMDKASDIWNMISQGAYLYVCGDAK 668 Y+E+ Q F + EL + + + + A+ + A +Y CG Sbjct: 310 -YDEKTQAFKKHVD--ELLAECANVDKIIVHTDTEPLINAAFLKEKSPAHADVYTCGSLA 366 Query: 669 GMAR 672 M Sbjct: 367 FMQA 370 >6O0A-A nrPDB Length = 413 Score = 37.5 bits (85), Expect = 0.023, Method: Composition-based stats. Identities = 19/123 (15%), Positives = 35/123 (28%), Gaps = 23/123 (18%) Query: 555 LPSDSKVPIIMIGPGTGLAPFRGFLQERLALVESGVELGPSVLFFGCRNRRMDFIYEEEL 614 L +D P+++I G G+ P F+++ A V+ + EL Sbjct: 273 LETDPNSPLVLICAGIGVTPVLAFVEKLAAQKSE-----REVMIIASSRSLAEAPLRGEL 327 Query: 615 QRFVESGALAELSVAFSREGPTKEYVQHKMMDKASDIWNM------ISQGAYLYVCGDAK 668 + K + + I A +++CG K Sbjct: 328 LERAKE------------LKKAKVLYGTTQEKDGDFVGRIDVSTLDIPANASVFLCGPLK 375 Query: 669 GMA 671 M Sbjct: 376 FMQ 378 >4U9U-A nrPDB Length = 281 Score = 36.7 bits (83), Expect = 0.032, Method: Composition-based stats. Identities = 23/114 (20%), Positives = 43/114 (37%), Gaps = 11/114 (9%) Query: 558 DSKVPIIMIGPGTGLAPFRGFLQERLALVESGVELGPSVLFFGCRNRRMDFIYEEELQRF 617 D+ ++ IG G G+AP R + ++L ++S ++G R++R F Y E+ Sbjct: 144 DTDAEMVFIGGGAGMAPMRSHIFDQLKRLKSKR---KMSYWYGARSKREMF-YVEDFDGL 199 Query: 618 VESGALAELSVAFSREGPTKE------YVQHKMMDKASDIWNMISQGAYLYVCG 665 A S P ++ + + + Y Y+CG Sbjct: 200 AAENDNFVWHCALSDPQPEDNWTGYTGFIHNVLYENYLKDHEAPEDCEY-YMCG 252 >4P6V-F nrPDB Length = 408 Score = 36.7 bits (83), Expect = 0.032, Method: Composition-based stats. Identities = 23/114 (20%), Positives = 43/114 (37%), Gaps = 11/114 (9%) Query: 558 DSKVPIIMIGPGTGLAPFRGFLQERLALVESGVELGPSVLFFGCRNRRMDFIYEEELQRF 617 D+ ++ IG G G+AP R + ++L ++S ++G R++R F Y E+ Sbjct: 271 DTDAEMVFIGGGAGMAPMRSHIFDQLKRLKSKR---KMSYWYGARSKREMF-YVEDFDGL 326 Query: 618 VESGALAELSVAFSREGPTKE------YVQHKMMDKASDIWNMISQGAYLYVCG 665 A S P ++ + + + Y Y+CG Sbjct: 327 AAENDNFVWHCALSDPQPEDNWTGYTGFIHNVLYENYLKDHEAPEDCEY-YMCG 379 >4WQM-A nrPDB Length = 326 Score = 36.3 bits (82), Expect = 0.042, Method: Composition-based stats. Identities = 45/244 (18%), Positives = 81/244 (33%), Gaps = 38/244 (15%) Query: 443 SPAGKDEYSKWVVESQRSLLEVMA-EFPSAKP----PLGVFFAGVAPRLQPRFYSISSSP 497 + +S VV + E+ + + P F P L R YS ++ Sbjct: 96 ASHPPKRFSTRVVSKRFLSDEMFELRLEAEQKVVFSPGQYFMVD-VPELGTRAYSAANPV 154 Query: 498 KIAETRIHVTCALVYEKMPTGRIHKGVCSTWMKNAVPYEKSENCSSAPIFVRQSNFKLPS 557 T L+ + +P G++ + + ++ L + Sbjct: 155 DGN------TLTLIVKAVPNGKVSCALANETIETLQLDGPYGLSV------------LKT 196 Query: 558 DSKVPIIMIGPGTGLAPFRGFLQERLALVESGVELGPSVLFFGCRNRRMDFIYEEELQRF 617 + + I G+G+AP + +A G E P +F+G R + E L + Sbjct: 197 ADETQSVFIAGGSGIAPMVSMVNTLIA---QGYE-KPITVFYGSR-LEAELEAAETLFGW 251 Query: 618 VESGALAELS---VAFSREGPTKEYVQHKMMDKASDIWNMISQGAYLYVCGDAKGMARDV 674 E+ L +S V S YV + + + GA Y+CG + M V Sbjct: 252 KENLKLINVSSSVVGNSESSYPTGYVHEIIPEYMEGLL-----GAEFYLCGPPQ-MINSV 305 Query: 675 HRSL 678 + L Sbjct: 306 QKLL 309 >2PIA-A nrPDB Length = 321 Score = 36.0 bits (81), Expect = 0.054, Method: Composition-based stats. Identities = 35/246 (14%), Positives = 75/246 (30%), Gaps = 46/246 (18%) Query: 430 SDPTEAERLKHLASPAGKDEYSKWVVESQRSLLEVMAEFPSAKPPLGVFFAGVAPRLQPR 489 + P E L+ + K W E + F G P R Sbjct: 1 TTPQEDGFLRLKIASKEKIARDIWSFELTDPQGAPLPPF-----EAGANLTVAVPNGSRR 55 Query: 490 FYSISSSPKIAETRIHVTCALVYEKMPTGRIHKGVCSTWMKNAVPYEKSENCSSAPIFVR 549 YS+ + + + + ++ GR G +++ + SE + + + Sbjct: 56 TYSLCNDSQERNRYV-----IAVKRDSNGR---GGSISFIDD-----TSEGDA-VEVSLP 101 Query: 550 QSNFKLPSDSKVPIIMIGPGTGLAPFRGFLQERLALVESGVELGPSVLFFGCRNRRMDFI 609 ++ F L +K I++ G G+ P ++ A G R+ R+ ++ Sbjct: 102 RNEFPLDKRAKS-FILVAGGIGITPMLSMARQLRAE--------------GLRSFRLYYL 146 Query: 610 YEEE-----LQRFVESGALAELSVAFSREGPTKEYVQHKMMDKASDIWNMISQGAYLYVC 664 + +++ + PTK + ++ ++Y C Sbjct: 147 TRDPEGTAFFDELTSDEWRSDVKIHHDHGDPTKAF-------DFWSVFEKSKPAQHVYCC 199 Query: 665 GDAKGM 670 G M Sbjct: 200 GPQALM 205 >2VNH-A nrPDB Length = 272 Score = 35.2 bits (79), Expect = 0.091, Method: Composition-based stats. Identities = 28/151 (18%), Positives = 53/151 (35%), Gaps = 24/151 (15%) Query: 489 RFYSISSSPKIAETRIHVTCALVYEKMPTGRIHKGVCSTWMKNAVPYEKSENCSSAPIFV 548 R YSI+S E + ++ G ++ +++ E+ P+ Sbjct: 64 RAYSIASPAWDEELEFYSI-----------KVPDGPLTSRLQHIKVGEQIILRPK-PVGT 111 Query: 549 RQSNFKLPSDSKVPIIMIGPGTGLAPFRGFLQERLALVESGVELGPSVLFFGCRNRRMDF 608 + LP + + GTG+APF ++E E+ + ++ CR Sbjct: 112 LVIDALLPGKR---LWFLATGTGIAPFASLMRE----PEAYEKFDEVIMMHACRTVAELE 164 Query: 609 IYEEELQRFVESGALAELSVAFSREGPTKEY 639 + ++ E + EL EG K Y Sbjct: 165 YGRQLVEALQEDPLIGELV-----EGKLKYY 190 >3FPK-A nrPDB Length = 251 Score = 33.6 bits (75), Expect = 0.27, Method: Composition-based stats. Identities = 36/172 (20%), Positives = 65/172 (37%), Gaps = 25/172 (14%) Query: 520 IHKGVCSTWMKNAVPYEKSENCSSAPIFVRQSNFKLPSDSKVPII-MIGPGTGLAPFRGF 578 + +G S + P ++ + S A F F L + M+ GT + P+ Sbjct: 73 VPQGKLSPRLAALKPGDEVQVVSDASGF-----FVLDEVPDCETLWMLATGTAIGPYLSI 127 Query: 579 LQERLALVESGVELGPSVLFFGCRNRRMDFIY---EEELQRFVESGALAELSVAFSRE-- 633 LQ V +++ D Y ELQ+ E G L + SRE Sbjct: 128 LQ-----YGQDVARFKNLVLVHAARFAADLSYLPLMLELQQRYE-GKL-RIQTVVSRENV 180 Query: 634 -----GPTKEYVQHKMMDKASDIWNMISQGAYLYVCGDAKGMARDVHRSLHT 680 G +++ ++KA + M + +++ +CG+ + M RD + L Sbjct: 181 PGSLTGRVPALIENGELEKAVGL-PMDKETSHVMLCGNPQ-MVRDTQQLLKE 230 >1TLB-A nrPDB Length = 326 Score = 33.6 bits (75), Expect = 0.31, Method: Composition-based stats. Identities = 35/214 (16%), Positives = 64/214 (29%), Gaps = 48/214 (22%) Query: 529 MKNAVPYEKSENCSSAPIFVRQSNFKLPSDSKV--PI------------IMIGPGTGLAP 574 + +V Y + + + + N +LP D K P+ ++I P AP Sbjct: 67 VNVSVVYGQLSPAAVSAMKADHKNLRLPEDPKTGLPVTDGVKFFACGLSMVIHPVNPHAP 126 Query: 575 FRGFLQERLALVESGVELGPSVLFFGCRNRRMDFIYEEE---LQRFVESGALAELSVAFS 631 + F G + ++YEE+ + + + + Sbjct: 127 TTHLNYRYFETWNQDGTP-QTWWFGGGADLTPSYLYEEDGQLFHQLHKDALDKHDTALYP 185 Query: 632 REGP---TKEYVQHKM--------------MDKASDIWNMISQGAYLYVCGDAKGMARDV 674 R Y+ H+ +I M+ C DA Sbjct: 186 RFKKWCDEYFYITHRKETRGIGGIFFDDYDERDPQEILKMVED------CFDA------F 233 Query: 675 HRSLHTIAQEQGSMDSTKAEGFVKNLQTSGRYLR 708 S TI + + M TK E + ++ GRY+ Sbjct: 234 LPSYLTIVKRRKDMPYTKEEQQWQAIR-RGRYVE 266 >2QDX-A nrPDB Length = 257 Score = 32.9 bits (73), Expect = 0.46, Method: Composition-based stats. Identities = 23/136 (16%), Positives = 48/136 (35%), Gaps = 21/136 (15%) Query: 467 EFPSAKPPLGVFFAGVAPRLQPRFYSISSSPKIAETRIHVTCALVYEKMPTGRIHKGVCS 526 F + + + P + R YSI+S + + + ++ G + Sbjct: 30 RFKTGQFVMIGLEVDGRPLM--RAYSIASPNYEE-----------HLEFFSIKVPDGPLT 76 Query: 527 TWMKNAVPYEKSENCSSAPIFVRQSNFKLPSDSKVPIIMIGPGTGLAPFRGFLQERLALV 586 + +++ + S P + LP + ++ GTG+APF +Q+ Sbjct: 77 SRLQH-LKEGDELMVSRKPTGTLVHDDLLPGKH---LYLLSTGTGMAPFLSVIQD----P 128 Query: 587 ESGVELGPSVLFFGCR 602 E+ +L G R Sbjct: 129 ETYERYEKVILVHGVR 144 >1FDR-A nrPDB Length = 248 Score = 32.9 bits (73), Expect = 0.47, Method: Composition-based stats. Identities = 34/202 (16%), Positives = 69/202 (34%), Gaps = 34/202 (16%) Query: 489 RFYSISSSPKIAETRIHVTCALVYEKMPTGRIHKGVCSTWMKNAVPYEKSENCSSAPIFV 548 R YS +SP + ++ G S + P ++ + S A F Sbjct: 50 RAYSYVNSPDNPDLEFYLVTV-----------PDGKLSPRLAALKPGDEVQVVSEAAGF- 97 Query: 549 RQSNFKLPSDSKVPII-MIGPGTGLAPFRGFLQERLALVESGVELGPSVLFFGCRNRRMD 607 F L + M+ GT + P+ L+ + ++ +++ D Sbjct: 98 ----FVLDEVPHCETLWMLATGTAIGPYLSILR-----LGKDLDRFKNLVLVHAARYAAD 148 Query: 608 FIYEEELQRFVE--SGALAELSVAFSRE-------GPTKEYVQHKMMDKASDIWNMISQG 658 Y +Q + G L + SRE G ++ ++ + M + Sbjct: 149 LSYLPLMQELEKRYEGKL-RIQTVVSRETAAGSLTGRIPALIESGELESTIGL-PMNKET 206 Query: 659 AYLYVCGDAKGMARDVHRSLHT 680 +++ +CG+ + M RD + L Sbjct: 207 SHVMLCGNPQ-MVRDTQQLLKE 227 >1TK1-A nrPDB Length = 260 Score = 31.7 bits (70), Expect = 1.2, Method: Composition-based stats. Identities = 19/105 (18%), Positives = 35/105 (33%), Gaps = 15/105 (14%) Query: 529 MKNAVPYEKSENCSSAPIFVRQSNFKLPSDSKV--PI------------IMIGPGTGLAP 574 + +V Y + + + + N +LP D K P+ ++I P AP Sbjct: 64 VNVSVVYGQLSPAAVSAMKADHKNLRLPEDPKTGLPVTDGVKFFACGLSMVIHPVNPHAP 123 Query: 575 FRGFLQERLALVESGVELGPSVLFFGCRNRRMDFIYEEELQRFVE 619 + F G + ++YEE+ Q F + Sbjct: 124 TTHLNYRYFETWNQDGTP-QTWWFGGGADLTPSYLYEEDGQLFHQ 167 >1GVH-A nrPDB Length = 396 Score = 31.7 bits (70), Expect = 1.2, Method: Composition-based stats. Identities = 38/215 (17%), Positives = 65/215 (30%), Gaps = 31/215 (14%) Query: 464 VMAEFPSAKPPLGVFFAGVAPRLQPRFYSISSSPKIAETRIHVTCALVYEKMPTGRIHKG 523 +AE+ + P + R YS++ P RI V K G G Sbjct: 179 AVAEYRPGQYLGVWLKPEGFPHQEIRQYSLTRKPDGKGYRIAV-------KREEG----G 227 Query: 524 VCSTWMKNAVPYEKSENCSSAPIFVRQSNFKLPSDSKVPIIMIGPGTGLAPFRGFLQERL 583 S W+ N AP +F + P+ +I G G P L Sbjct: 228 QVSNWLHNHANVG-DVVKLVAPA----GDFFMAVADDTPVTLISAGVGQTPMLAMLDTLA 282 Query: 584 ALVESGVELGPSVLFFGCRNRRMDFIYEEELQRFVESGALAELSVAFSREGPTKEYVQHK 643 + + F N + + +E++ G A + E + K Sbjct: 283 KAGHTAQV---NW-FHAAENGDV-HAFADEVKEL---GQSLPRFTAHTWYRQPSEADRAK 334 Query: 644 MMDKASDIWNMIS-QGAY------LYVCGDAKGMA 671 + + ++ +GA+ Y+CG M Sbjct: 335 GQFDSEGLMDLSKLEGAFSDPTMQFYLCGPVGFMQ 369 >5MWL-A nrPDB Length = 471 Score = 31.3 bits (69), Expect = 1.4, Method: Composition-based stats. Identities = 19/147 (12%), Positives = 42/147 (28%), Gaps = 15/147 (10%) Query: 530 KNAVPYEKSENCSSAPIFVRQSNFKLPSDSKVPIIMIGPGTGLAPFRGFLQERLALVESG 589 + S P R F + + I P G PF + + Sbjct: 104 CDKDLDTFSGYAMCLPNLTRLQTFHFAEHRPILCVEIKPKCGFIPFSNDVTHEMKHKV-- 161 Query: 590 VELGPSVLFFGCRNRRMDFIYEEELQRFVESGALAELSVAFSREGPTKEYVQHKMMDKAS 649 CR + + ++ + L + + ++ + + + Sbjct: 162 -----------CRYCMHQHL-KVATGKWKKISKYCPLDLYSGNKQRMHFALRSLLQETQN 209 Query: 650 DIWNMISQGAYLYVCGDAKGMARDVHR 676 ++ + G +Y CGDA+ D+ Sbjct: 210 NL-RIFKNGELIYGCGDARSPVADLKE 235 >2EIX-A nrPDB Length = 243 Score = 31.3 bits (69), Expect = 1.5, Method: Composition-based stats. Identities = 16/64 (25%), Positives = 26/64 (40%), Gaps = 4/64 (6%) Query: 565 MIGPGTGLAPFRGFLQERLALVESGVELGPSVLFFGCRNRRMDFIYEEELQRFVESGALA 624 MI GTG+ P LQ A++++ E L F N D + EL + + Sbjct: 121 MIAGGTGITP---MLQVARAIIKNPKEKTIINLIFANVNED-DILLRTELDDMAKKYSNF 176 Query: 625 ELSV 628 ++ Sbjct: 177 KVYY 180 >6F4A-A nrPDB Length = 832 Score = 31.3 bits (69), Expect = 1.5, Method: Composition-based stats. Identities = 36/196 (18%), Positives = 66/196 (33%), Gaps = 17/196 (8%) Query: 284 SIHDSEDAKFNDINMANGNGYTVFDAQHPYKANVAVKRELHTPESDRSCIHLEFDIAGSG 343 IHD F D + D + + ++ + + EF I + Sbjct: 563 RIHDDNAVVFGDGFNKGLVSLSPDDD-----GELCIPTFYDQSQTKSTLLVSEFMILTNK 617 Query: 344 LT---YETGDHVGVL-CDNLSETVDEA---LRLL--DMSPDTYFSLHAEKEDGTPISSSL 394 L ++ GV C N ++A LL ++ SL + + +SSS Sbjct: 618 LCAAFFQENKIPGVYRCYNGLNLGNQAKAQFELLKENIKLGKLPSLKDITKISSQLSSSF 677 Query: 395 PPPFPPCNLRTALTRYACLLSSPKKSALVALAAHASDPTEAERLKHLASPAGKDEYSKWV 454 PFP + T Y + S ++ L H ++L D+Y W Sbjct: 678 YSPFPLPHKMIGNTAYLTVTSPMRRGP--DLINHLQLHRFLKKLPLCFKQEYLDQY-VWS 734 Query: 455 VESQRSLLEVMAEFPS 470 +++ +L++ S Sbjct: 735 FQARADILKIFQRHSS 750 >5UFA-A nrPDB Length = 267 Score = 31.3 bits (69), Expect = 1.6, Method: Composition-based stats. Identities = 36/259 (13%), Positives = 86/259 (33%), Gaps = 44/259 (16%) Query: 445 AGKDEYSKWVVESQRSLLEVMAEFPSAKPPLGVFFAGVAPRLQP--------RFYSISSS 496 + + ++++ + + + F ++P F AG RL R YS+ S+ Sbjct: 12 SPEAKFTEEKILWVKHHTPKLITFAISRPESYRFKAGQFSRLGFYEGKGFIWRAYSVVSA 71 Query: 497 PKIAETRIHVTCALVYEKMPTGRIHKGVCSTWMKNAVPYEKSENCSSAPIFVRQSNFKLP 556 + L+ G + + + +K+ P + P Sbjct: 72 --EYADTLEYFAVLI----QDGPMSALFAKMQQGDTILLDKNATGFLLPE-------RFP 118 Query: 557 SDSKVPIIMIGPGTGLAPFRGFLQERLALVESGVELGPSVLFFGCRNRRMDFIYEEELQR 616 ++M+ G+G+APF L++ +V + + I+ + L Sbjct: 119 DGKD--LVMLCTGSGIAPFLSILEQPEIRQRFD-----TVNLIHSVSFPEELIFNDRLAA 171 Query: 617 FVESGALAELSVAF------SREGPTK----EYVQHKMM----DKASDIWNMISQGAYLY 662 E + E +F +R + + + ++A + + Sbjct: 172 LSEHPLVGEYGHSFRFVPVTTRAANPSGLSGKRIPELLKNNSIEQALHT-KLTPESTRFM 230 Query: 663 VCGDAKGMARDVHRSLHTI 681 +CG+ + M +D ++L + Sbjct: 231 ICGNPE-MVKDTFQTLLDM 248 >4FK8-A nrPDB Length = 271 Score = 30.9 bits (68), Expect = 2.0, Method: Composition-based stats. Identities = 17/93 (18%), Positives = 35/93 (37%), Gaps = 15/93 (16%) Query: 489 RFYSISSSPKIAETRIHVTCALVYEKMPTGRIHKGVCSTWMKNAVPYEKSENCSSAPIFV 548 R YSI S + + + ++ G ++ +++ + P Sbjct: 66 RAYSIVSPNYEE-----------HLEFFSIKVQNGPLTSRLQH-LKVGDPVLIGKKPTGT 113 Query: 549 RQSNFKLPSDSKVPIIMIGPGTGLAPFRGFLQE 581 ++ LP + M+ GTGLAPF +++ Sbjct: 114 LVADNLLPGK---TLWMLSTGTGLAPFMSIIRD 143 >2RCQ-A nrPDB Length = 141 Score = 30.6 bits (67), Expect = 2.3, Method: Composition-based stats. Identities = 17/68 (25%), Positives = 25/68 (36%), Gaps = 5/68 (7%) Query: 602 RNRRMDFIYEEELQRFVESGALAELSVAFSREGPTKEYVQHKMMDKASDIWNMISQGAYL 661 RN +DF E + +S + + EG VQ + W +G L Sbjct: 62 RNYDVDFTVGVEFDEYTKSLDNRHVKALVTWEGDVLVCVQKGEKENRG--WKQWIEGDKL 119 Query: 662 YV---CGD 666 Y+ CGD Sbjct: 120 YLELTCGD 127 >5J5Z-A nrPDB Length = 496 Score = 30.6 bits (67), Expect = 2.3, Method: Composition-based stats. Identities = 33/153 (21%), Positives = 57/153 (37%), Gaps = 17/153 (11%) Query: 556 PSDSKVPIIMIGPGTGLAPFRGF-LQERLALVESGVELGPSVLFFGCRNRRMDFIYEEEL 614 P D+ V +I GPG +A + L + +E LG + L GC + + Sbjct: 26 PIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKA-LLNNSHY 84 Query: 615 QRFVESGALAELSVAFSR--EGPTKEYVQHKMMDKASDIWNMISQG-AYLYVCGDAKGMA 671 A SR E KMM++ S ++ G A+L+ Sbjct: 85 YHMAHGKDFA------SRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLF------KQN 132 Query: 672 RDVHRSLHTIAQEQGSMDSTKAEGFVKNLQTSG 704 + VH + + + + +TKA+G + + T Sbjct: 133 KVVHVNGYGKITGKNQVTATKADGGTQVIDTKN 165 >6D35-A nrPDB Length = 600 Score = 30.2 bits (66), Expect = 3.4, Method: Composition-based stats. Identities = 16/66 (24%), Positives = 28/66 (42%), Gaps = 3/66 (4%) Query: 591 ELGPSVLFFGCRNRRMDFIYEEELQRFVESGALAELSVAFSREGPTKEYVQHKMMDKASD 650 G ++ FGC DF + E +R L E +VA + E K + + ++ S Sbjct: 504 AFGFVLITFGCHFY--DFFNQAEWERSFREYVLCEANVAIA-EQTNKPIPECYIKNRPSL 560 Query: 651 IWNMIS 656 + I+ Sbjct: 561 LVEKIN 566 >1EII-A nrPDB Length = 134 Score = 29.8 bits (65), Expect = 4.7, Method: Composition-based stats. Identities = 17/68 (25%), Positives = 24/68 (35%), Gaps = 5/68 (7%) Query: 602 RNRRMDFIYEEELQRFVESGALAELSVAFSREGPTKEYVQHKMMDKASDIWNMISQGAYL 661 RN +DF E + + + EG T VQ + W +G L Sbjct: 59 RNYDLDFTVGVEFDEHTKGLDGRNVKTLVTWEGNTLVCVQKGEKENRG--WKQWVEGDKL 116 Query: 662 YV---CGD 666 Y+ CGD Sbjct: 117 YLELTCGD 124 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.307 0.121 0.303 Lambda K H 0.267 0.0377 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 23,424,523 Number of Sequences: 36641 Number of extensions: 896092 Number of successful extensions: 2838 Number of sequences better than 10.0: 69 Number of HSP's better than 10.0 without gapping: 55 Number of HSP's successfully gapped in prelim test: 64 Number of HSP's that attempted gapping in prelim test: 2592 Number of HSP's gapped (non-prelim): 132 length of query: 711 length of database: 10,336,785 effective HSP length: 104 effective length of query: 607 effective length of database: 6,526,121 effective search space: 3961355447 effective search space used: 3961355447 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.2 bits) S2: 62 (28.6 bits)