BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q9SSD1 (496 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 5XJX-C nrPDB 879 0.0 1OGQ-A nrPDB 95 6e-20 6HLU-A nrPDB 69 5e-12 6O00-A nrPDB 60 2e-09 5Y3M-A nrPDB 54 2e-07 3CIG-A nrPDB 54 2e-07 5Y3K-A nrPDB 54 2e-07 3ULU-A nrPDB 52 7e-07 4R6F-A nrPDB 52 9e-07 3WPI-A nrPDB 50 2e-06 2Z80-A nrPDB 50 2e-06 2Z7X-A nrPDB 50 3e-06 6GFF-I nrPDB 49 5e-06 1XCD-A nrPDB 48 8e-06 5ZSN-B nrPDB 48 9e-06 5D3I-A nrPDB 48 9e-06 3J0A-A nrPDB 48 1e-05 3A7C-A nrPDB 48 1e-05 5LFN-A nrPDB 46 4e-05 2XOT-A nrPDB 46 4e-05 3B2D-A nrPDB 44 1e-04 3A79-B nrPDB 44 2e-04 5YQ5-A nrPDB 41 0.001 2V9T-B nrPDB 40 0.002 4PUF-A nrPDB 40 0.002 5MX0-A nrPDB 40 0.003 4R08-A nrPDB 39 0.004 5GY2-A nrPDB 39 0.005 3RG1-A nrPDB 39 0.006 5Y31-B nrPDB 38 0.009 6J5T-G nrPDB 36 0.033 3T6Q-A nrPDB 36 0.036 3V44-A nrPDB 36 0.039 2FT3-A nrPDB 35 0.062 3G06-A nrPDB 35 0.077 2Z7X-B nrPDB 34 0.15 6HKW-A nrPDB 33 0.24 4QDH-A nrPDB 32 0.69 6EZL-A nrPDB 32 0.79 3IBG-A nrPDB 30 3.3 >5XJX-C nrPDB Length = 433 Score = 879 bits (2270), Expect = 0.0, Method: Compositional matrix adjust. Identities = 433/433 (100%), Positives = 433/433 (100%) Query: 28 TSDSTAPSALIDGPQTGFTMTNDGARTEPDEQDAVYDIMRATGNDWAAAIPDVCRGRWHG 87 TSDSTAPSALIDGPQTGFTMTNDGARTEPDEQDAVYDIMRATGNDWAAAIPDVCRGRWHG Sbjct: 1 TSDSTAPSALIDGPQTGFTMTNDGARTEPDEQDAVYDIMRATGNDWAAAIPDVCRGRWHG 60 Query: 88 IECMPDQDNVYHVVSLSFGALSDDTAFPTCDPQRSYVSESLTRLKHLKALFFYRCLGRAP 147 IECMPDQDNVYHVVSLSFGALSDDTAFPTCDPQRSYVSESLTRLKHLKALFFYRCLGRAP Sbjct: 61 IECMPDQDNVYHVVSLSFGALSDDTAFPTCDPQRSYVSESLTRLKHLKALFFYRCLGRAP 120 Query: 148 QRIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFS 207 QRIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFS Sbjct: 121 QRIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFS 180 Query: 208 GLRSLDLSGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTG 267 GLRSLDLSGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTG Sbjct: 181 GLRSLDLSGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTG 240 Query: 268 PIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLK 327 PIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLK Sbjct: 241 PIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLK 300 Query: 328 NLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLNDNSL 387 NLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLNDNSL Sbjct: 301 NLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLNDNSL 360 Query: 388 TGPVPFERDTVWRMRRKLRLYNNAGLCVNRDSDLDDAFGSKSGSTVRLCDAETSRPAPSG 447 TGPVPFERDTVWRMRRKLRLYNNAGLCVNRDSDLDDAFGSKSGSTVRLCDAETSRPAPSG Sbjct: 361 TGPVPFERDTVWRMRRKLRLYNNAGLCVNRDSDLDDAFGSKSGSTVRLCDAETSRPAPSG 420 Query: 448 TVQHLSREEDGAL 460 TVQHLSREEDGAL Sbjct: 421 TVQHLSREEDGAL 433 >1OGQ-A nrPDB Length = 313 Score = 95.1 bits (235), Expect = 6e-20, Method: Compositional matrix adjust. Identities = 93/322 (28%), Positives = 139/322 (43%), Gaps = 48/322 (14%) Query: 55 EPDEQDAVYDIMRATGN-----DWAAAIPDVCRGRWHGIECMPDQDNVYHVVSLSFGALS 109 P ++ A+ I + GN W D C W G+ C D Y V +L L+ Sbjct: 4 NPQDKQALLQIKKDLGNPTTLSSWLPTT-DCCNRTWLGVLCDTDTQ-TYRVNNLDLSGLN 61 Query: 110 DDTAFPTCDPQRSYVSESLTRLKHLKALFFYRCLGRAPQRIPAFLGRLGSSLQTLVLREN 169 +P + SL L +L L+ +G + N Sbjct: 62 LPKPYP--------IPSSLANLPYLNFLY---------------IGGI-----------N 87 Query: 170 GFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPGFV-- 227 +GPIP + LT L L + +++G+IP ++ L +LD S N L+G++P + Sbjct: 88 NLVGPIPPAIAKLTQLHYLYITHTNVSGAIPDFLSQIKTLVTLDFSYNALSGTLPPSISS 147 Query: 228 LPALSVLDLNQNLLTGPVPPTLTSCGSLI-KIDLSRNRVTGPIPESINRLNQLVLLDLSY 286 LP L + + N ++G +P + S L + +SRNR+TG IP + LN L +DLS Sbjct: 148 LPNLVGITFDGNRISGAIPDSYGSFSKLFTSMTISRNRLTGKIPPTFANLN-LAFVDLSR 206 Query: 287 NRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKS 346 N L G + Q + L N S KNL L L N I G++P+ Sbjct: 207 NMLEGDASVLFGSDKNTQKIHLAKN---SLAFDLGKVGLSKNLNGLDLRNNRIYGTLPQG 263 Query: 347 LTRLNSLRVLHLEGNNLTGEIP 368 LT+L L L++ NNL GEIP Sbjct: 264 LTQLKFLHSLNVSFNNLCGEIP 285 Score = 72.4 bits (176), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 65/208 (31%), Positives = 100/208 (48%), Gaps = 10/208 (4%) Query: 209 LRSLDLSGNRLTGS--IPGFV--LPALSVLDLNQ-NLLTGPVPPTLTSCGSLIKIDLSRN 263 + +LDLSG L IP + LP L+ L + N L GP+PP + L + ++ Sbjct: 52 VNNLDLSGLNLPKPYPIPSSLANLPYLNFLYIGGINNLVGPIPPAIAKLTQLHYLYITHT 111 Query: 264 RVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAF 323 V+G IP+ ++++ LV LD SYN LSG P S+ L +L + GN + S IP++ Sbjct: 112 NVSGAIPDFLSQIKTLVTLDFSYNALSGTLPPSISSLPNLVGITFDGN-RISGAIPDSYG 170 Query: 324 KGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLN 383 K + +S + G IP + LN L + L N L G+ + F K+ ++ L Sbjct: 171 SFSKLFTSMTISRNRLTGKIPPTFANLN-LAFVDLSRNMLEGDASVLFGSDKNTQKIHLA 229 Query: 384 DNSLT---GPVPFERDTVWRMRRKLRLY 408 NSL G V ++ R R+Y Sbjct: 230 KNSLAFDLGKVGLSKNLNGLDLRNNRIY 257 >6HLU-A nrPDB Length = 974 Score = 68.9 bits (167), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 73/215 (33%), Positives = 100/215 (46%), Gaps = 16/215 (7%) Query: 179 LGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPGFVLPALSVLDLNQ 238 L +L +L L L N + PL+ L L LSGN ++ P L +L+ L L+ Sbjct: 153 LESLKSLTELQLSSNQITDIAPLA--SLKSLTELSLSGNNISDIAPLESLKSLTELSLSS 210 Query: 239 NLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQ 298 N +T P L S SL ++ LS N+++ P + L L L LS N++S P L+ Sbjct: 211 NQITDIAP--LASLKSLTELSLSSNQISDIAP--LESLKSLTELQLSRNQISDIAP--LE 264 Query: 299 GLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHL 358 L SL L L N + + P LK+L L LS I P L LNSL L L Sbjct: 265 SLKSLTELQLSSN-QITDIAP---LASLKSLTELQLSRNQISDIAP--LESLNSLSKLWL 318 Query: 359 EGNNLTGEIPLEFRDVKHLSELRLNDNSLTGPVPF 393 GN +T PL + L+EL L+ N +T P Sbjct: 319 NGNQITDIAPL--ASLNSLTELELSSNQITDIAPL 351 Score = 52.4 bits (124), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 62/192 (32%), Positives = 89/192 (46%), Gaps = 21/192 (10%) Query: 263 NRVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENA 322 N++T P + LN L +L L N+++ P L LNSL L L GN K S P Sbjct: 101 NQITDISP--LASLNSLSMLWLDRNQITDIAP--LASLNSLSMLWLFGN-KISDIAP--- 152 Query: 323 FKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRL 382 + LK+L L LS+ I P L L SL L L GNN++ PLE +K L+EL L Sbjct: 153 LESLKSLTELQLSSNQITDIAP--LASLKSLTELSLSGNNISDIAPLE--SLKSLTELSL 208 Query: 383 NDNSLTGPVPFERDTVWRMRRKLRLYNNAGLCVNRDSDLDDAFGSKSGSTVRLCDAETSR 442 + N +T P L+ L N+ SD+ KS + ++L + S Sbjct: 209 SSNQITDIAPL---------ASLKSLTELSLSSNQISDIAPLESLKSLTELQLSRNQISD 259 Query: 443 PAPSGTVQHLSR 454 AP +++ L+ Sbjct: 260 IAPLESLKSLTE 271 >6O00-A nrPDB Length = 820 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 82/293 (27%), Positives = 130/293 (44%), Gaps = 26/293 (8%) Query: 121 RSYVSESLTRLKHLKALFFYRCLGRAPQRIPAFLGRLGSSLQTLVLRENGFLGPIPDELG 180 R V + L LK LK L L + PQ + +G LQ L + G + + L Sbjct: 533 RYIVIDGLRELKRLKVLRLKSNLSKLPQVV----TDVGVHLQKLSINNEGTKLIVLNSLK 588 Query: 181 NLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTG--SIPGFV-LPALSVLDLN 237 + NL L+L + L IP S L+ +DL N L I F L L+ L L Sbjct: 589 KMVNLTELELIRCDLE-RIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLW 647 Query: 238 QNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSL 297 N + +P + + +L ++ L+RN++ IP + +L LDLS+N L+ P+ + Sbjct: 648 YNHI-AYIPIQIGNLTNLERLYLNRNKIEK-IPTQLFYCRKLRYLDLSHNNLTF-LPADI 704 Query: 298 QGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLH 357 L +LQ L + N +P F+ + L L L N N+ S+P + L +L + Sbjct: 705 GLLQNLQNLAVTANR--IEALPPELFQC-RKLRALHLGN-NVLQSLPSRVGELTNLTQIE 760 Query: 358 LEGNNLT------GEIPLEFRDVKHLSELRLNDNSLTGPVPFERDTVWRMRRK 404 L GN L GE PL R S L + ++ + P ++ +WR ++ Sbjct: 761 LRGNRLECLPVELGECPLLKR-----SGLVVEEDLFSTLPPEVKERLWRADKE 808 Score = 37.0 bits (84), Expect = 0.019, Method: Compositional matrix adjust. Identities = 78/282 (27%), Positives = 113/282 (40%), Gaps = 36/282 (12%) Query: 127 SLTRLKHLKALFFYRCLGRAPQRIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLK 186 S+ +L LK L+ Y + AFL +L+ L ++ + IP + +L L+ Sbjct: 464 SIAQLTGLKELWLYHTAAKIEAPALAFLR---ENLRALHIKFTD-IKEIPLWIYSLKTLE 519 Query: 187 VLDLHKNHLNGSIPLSFNRF---SGLRSLD-LSGNRLTGSIP---------GFVLPALSV 233 L HL G++ NR+ GLR L L RL ++ G L LS+ Sbjct: 520 EL-----HLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSI 574 Query: 234 LDLNQNLLTGPVPPTLTSCGSL--IKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSG 291 + L+ + + L I+ DL R IP SI L+ L +DL N L Sbjct: 575 NNEGTKLIVLNSLKKMVNLTELELIRCDLER------IPHSIFSLHNLQEIDLKDNNLKT 628 Query: 292 PFPS-SLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRL 350 S Q L+ L L L N I L NL L L+ I+ IP L Sbjct: 629 IEEIISFQHLHRLTCLKLWYNHIAYIPI---QIGNLTNLERLYLNRNKIE-KIPTQLFYC 684 Query: 351 NSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLNDNSLTGPVP 392 LR L L NNLT +P + +++L L + N + P Sbjct: 685 RKLRYLDLSHNNLTF-LPADIGLLQNLQNLAVTANRIEALPP 725 >5Y3M-A nrPDB Length = 801 Score = 53.9 bits (128), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 78/279 (27%), Positives = 122/279 (43%), Gaps = 46/279 (16%) Query: 177 DELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSIP-----GFVLPAL 231 L L L+ L L N +N + F F L +DLS NR++G+ G V + Sbjct: 364 QSLTRLPKLQSLHLQLNFINQAQLSIFGAFPSLLFVDLSDNRISGAATPAAALGEVDSRV 423 Query: 232 SVLDLNQNLLTGPVPPT-----LTSCGSLIKIDLSRNRVTGPIPESINRLNQLV------ 280 V L + L GP+ + SC +DLSRN + E RL++L Sbjct: 424 EVWRLPRGLAPGPLDAVSSKDFMPSCNLNFTLDLSRNNLVTIQQEMFTRLSRLQCLRLSH 483 Query: 281 -------------------LLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTK-FSTT-IP 319 +LDLS+N+L S L L+AL L N++ FS + Sbjct: 484 NSISQAVNGSQFVPLTSLRVLDLSHNKLDLYHGRSFTELPQLEALDLSYNSQPFSMQGVG 543 Query: 320 ENA--FKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLT-----GEIPLE-F 371 N L +L L L++ I + + L+ SLR L GN+L+ G++ L F Sbjct: 544 HNLSFVAQLPSLRYLSLAHNGIHSRVSQKLSS-ASLRALDFSGNSLSQMWAEGDLYLCFF 602 Query: 372 RDVKHLSELRLNDNSLTGPVPFERDTVWRMRRKLRLYNN 410 + +++L +L L++N L +P D + + R+LRL +N Sbjct: 603 KGLRNLVQLDLSENHLHTLLPRHLDNLPKSLRQLRLRDN 641 Score = 49.3 bits (116), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 83/251 (33%), Positives = 107/251 (42%), Gaps = 31/251 (12%) Query: 159 SSLQTLVLRENGFLGPIP-DELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGN 217 S LQ L L N + + LT+L+VLDL N L+ SF L +LDLS N Sbjct: 474 SRLQCLRLSHNSISQAVNGSQFVPLTSLRVLDLSHNKLDLYHGRSFTELPQLEALDLSYN 533 Query: 218 RLTGSIPG------FV--LPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPI 269 S+ G FV LP+L L L N + V L+S SL +D S N ++ Sbjct: 534 SQPFSMQGVGHNLSFVAQLPSLRYLSLAHNGIHSRVSQKLSS-ASLRALDFSGNSLSQMW 592 Query: 270 PES------INRLNQLVLLDLSYNRLSGPFPSSLQGL-NSLQALMLKGNT----KFS--T 316 E L LV LDLS N L P L L SL+ L L+ N +S T Sbjct: 593 AEGDLYLCFFKGLRNLVQLDLSENHLHTLLPRHLDNLPKSLRQLRLRDNNLAFFNWSSLT 652 Query: 317 TIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKH 376 +P L + LSN GS+P + RL L V N++ IP F Sbjct: 653 VLPRLEALDLAGNQLKALSN----GSLPPGI-RLQKLDV---SSNSIGFVIPGFFVRATR 704 Query: 377 LSELRLNDNSL 387 L EL L+ N+L Sbjct: 705 LIELNLSANAL 715 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 80/295 (27%), Positives = 115/295 (38%), Gaps = 78/295 (26%) Query: 140 YRCLGRAPQRIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDL--------H 191 Y L P+R+P SL TL+L N + P++L NLT L+VLD+ H Sbjct: 187 YNNLTEVPRRLPP-------SLDTLLLSYNHIVTLAPEDLANLTALRVLDVGGNCRRCDH 239 Query: 192 KNHLNGSIPLSFNR-----FSGLRSLDLSGNRLTGSIPGFVLPALSVLDLNQNLLTGPVP 246 + P +F + FS L L+ G VL S+ L ++ G Sbjct: 240 ARNPCRECPKNFPKLHPDTFSHLSRLE-----------GLVLKDSSLYKLEKDWFRG--- 285 Query: 247 PTLTSCGSLIKIDLSRNRVTGPIPES--INRLNQLVLLDLSYNRLSG------PFPSSLQ 298 G L +DLS N + I ++ N L QL L+LS+N SS Sbjct: 286 -----LGRLQVLDLSENFLYDYITKTTIFNDLTQLRRLNLSFNYHKKVSFAHLHLASSFG 340 Query: 299 GLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHL 358 L SL+ L + G F+ L N+ + +SLTRL L+ LHL Sbjct: 341 SLVSLEKLDMHGIF----------FRSLTNITL-------------QSLTRLPKLQSLHL 377 Query: 359 EGNNLTGEIPLEFRDVKHLSELRLNDNSLTGPVP--------FERDTVWRMRRKL 405 + N + F L + L+DN ++G R VWR+ R L Sbjct: 378 QLNFINQAQLSIFGAFPSLLFVDLSDNRISGAATPAAALGEVDSRVEVWRLPRGL 432 Score = 42.0 bits (97), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 45/123 (36%), Positives = 58/123 (47%), Gaps = 15/123 (12%) Query: 182 LTNLKVLDLHKNHLNGSIPLSFNRF-SGLRSLDLSGNRLT----GSIPGFVLPALSVLDL 236 L NL LDL +NHL+ +P + LR L L N L S+ VLP L LDL Sbjct: 605 LRNLVQLDLSENHLHTLLPRHLDNLPKSLRQLRLRDNNLAFFNWSSLT--VLPRLEALDL 662 Query: 237 NQNLL----TGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSGP 292 N L G +PP + L K+D+S N + IP R +L+ L+LS N L Sbjct: 663 AGNQLKALSNGSLPPGI----RLQKLDVSSNSIGFVIPGFFVRATRLIELNLSANALKTV 718 Query: 293 FPS 295 PS Sbjct: 719 DPS 721 Score = 30.4 bits (67), Expect = 2.0, Method: Compositional matrix adjust. Identities = 56/211 (26%), Positives = 89/211 (42%), Gaps = 29/211 (13%) Query: 180 GNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPGFVLPALSVLDLNQN 239 N+T+L ++ +HL+ S F S LR L+L N + P ++ Sbjct: 42 ANVTSLSLISNRIHHLHDS---DFVHLSNLRVLNLKWNCPPAGLSPMHFPCRMTIE---- 94 Query: 240 LLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQG 299 P T + +L +++LS N +T +P + L L L S L P+ G Sbjct: 95 ------PNTFLAVPTLEELNLSYNGITT-VPALPSSLVSLSLSHTSILVLG---PTHFTG 144 Query: 300 LNSLQALMLKGNTKFSTTIPE------NAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSL 353 L++L+ L + GN + P A GL NL L L N+ +P+ L SL Sbjct: 145 LHALRFLYMDGNCYYMNPCPRALEVAPGALLGLGNLTHLSLKYNNLT-EVPRRLPP--SL 201 Query: 354 RVLHLEGNNLTGEIPLEFRDVKHLSELRLND 384 L L N++ P D+ +L+ LR+ D Sbjct: 202 DTLLLSYNHIVTLAP---EDLANLTALRVLD 229 >3CIG-A nrPDB Length = 697 Score = 53.5 bits (127), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 42/122 (34%), Positives = 59/122 (48%), Gaps = 4/122 (3%) Query: 172 LGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPGF--VLP 229 L IPD+L +N+ VL+L N L P +F R+S L LD N ++ P +LP Sbjct: 16 LTHIPDDLP--SNITVLNLTHNQLRRLPPTNFTRYSQLAILDAGFNSISKLEPELCQILP 73 Query: 230 ALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRL 289 L VL+L N L+ T C +L ++DL N + L+ LDLS+N L Sbjct: 74 LLKVLNLQHNELSQISDQTFVFCTNLTELDLMSNSIHKIKSNPFKNQKNLIKLDLSHNGL 133 Query: 290 SG 291 S Sbjct: 134 SS 135 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 51/166 (30%), Positives = 74/166 (44%), Gaps = 9/166 (5%) Query: 231 LSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINR-LNQLVLLDLSYNRL 289 L L+L +N ++ T + G L +DL N + + R L + + LSYN+ Sbjct: 383 LLTLNLTKNHISKIANGTFSWLGQLRILDLGLNEIEQKLSGQEWRGLRNIFEIYLSYNKY 442 Query: 290 SGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTR 349 SS + SLQ LML+ + I + F+ L+NL IL LSN NI L Sbjct: 443 LQLSTSSFALVPSLQRLMLRRVALKNVDISPSPFRPLRNLTILDLSNNNIANINEDLLEG 502 Query: 350 LNSLRVLHLEGNNLTGEI-------PLEF-RDVKHLSELRLNDNSL 387 L +L +L + NNL P+ F + + HL L L N L Sbjct: 503 LENLEILDFQHNNLARLWKRANPGGPVNFLKGLSHLHILNLESNGL 548 Score = 37.7 bits (86), Expect = 0.012, Method: Compositional matrix adjust. Identities = 58/194 (29%), Positives = 86/194 (44%), Gaps = 15/194 (7%) Query: 179 LGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPGFVLPALSV----- 233 LGN ++L+ LDL N L P F L +L L+ +L + + LS Sbjct: 168 LGN-SSLRKLDLSSNPLKEFSPGCFQTIGKLFALLLNNAQLNPHLTEKLCWELSNTSIQN 226 Query: 234 LDLNQNLLTGPVPPTLT--SCGSLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSG 291 L L N L T + +L ++DLS N + S + L L L L YN + Sbjct: 227 LSLANNQLLATSESTFSGLKWTNLTQLDLSYNNLHDVGNGSFSYLPSLRYLSLEYNNIQR 286 Query: 292 PFPSSLQGLNSLQALMLK-GNTKFSTTIPEN------AFKGLKNLMILVLSNTNIQGSIP 344 P S GL++L+ L LK TK S ++ + +F+ LK L L + + NI + Sbjct: 287 LSPRSFYGLSNLRYLSLKRAFTKQSVSLASHPNIDDFSFQWLKYLEYLNMDDNNIPSTKS 346 Query: 345 KSLTRLNSLRVLHL 358 + T L SL+ L L Sbjct: 347 NTFTGLVSLKYLSL 360 Score = 30.0 bits (66), Expect = 2.6, Method: Compositional matrix adjust. Identities = 66/238 (27%), Positives = 95/238 (39%), Gaps = 23/238 (9%) Query: 185 LKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPGFVLPALS---VLDLNQNLL 241 L L+L KNH++ +F+ LR LDL N + + G L + L+ N Sbjct: 383 LLTLNLTKNHISKIANGTFSWLGQLRILDLGLNEIEQKLSGQEWRGLRNIFEIYLSYNKY 442 Query: 242 TGPVPPTLTSCGSLIKIDLSR----NRVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSL 297 + SL ++ L R N P P L L +LDLS N ++ L Sbjct: 443 LQLSTSSFALVPSLQRLMLRRVALKNVDISPSP--FRPLRNLTILDLSNNNIANINEDLL 500 Query: 298 QGLNSLQALMLKGNT------KFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLN 351 +GL +L+ L + N + + P N KGL +L IL L + + L Sbjct: 501 EGLENLEILDFQHNNLARLWKRANPGGPVNFLKGLSHLHILNLESNGLDEIPVGVFKNLF 560 Query: 352 SLRVLHLEGNNLTGEIPLEFRDVKHLSELRLNDNSLT-------GPVPFERDTVWRMR 402 L+ ++L NNL P F D L L L N +T GP PF+ MR Sbjct: 561 ELKSINLGLNNLNKLEPFIFDDQTSLRSLNLQKNLITSVEKDVFGP-PFQNLNSLDMR 617 >5Y3K-A nrPDB Length = 802 Score = 53.5 bits (127), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 80/253 (31%), Positives = 108/253 (42%), Gaps = 20/253 (7%) Query: 151 PAFLGRLGSSLQTLVLRENGFLGPI-PDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGL 209 P +L S LQ L L N + + LT+L+VLDL N L+ SF L Sbjct: 468 PEMFAQL-SRLQCLRLSHNSISQAVNGSQFVPLTSLQVLDLSHNKLDLYHGRSFTELPRL 526 Query: 210 RSLDLSGNRLTGSIPG------FV--LPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLS 261 +LDLS N S+ G FV LP L L L N + V L S SL +D S Sbjct: 527 EALDLSYNSQPFSMRGVGHNLSFVAQLPTLRYLSLAHNGIHSRVSQQLCST-SLWALDFS 585 Query: 262 RNRVTGPIPES------INRLNQLVLLDLSYNRLSGPFPSSLQGL-NSLQALMLKGNTKF 314 N ++ E L L+ LDLS NRL P +L L SLQ L L+ N + Sbjct: 586 GNSLSQMWAEGDLYLRFFQGLRSLIRLDLSQNRLHTLLPCTLGNLPKSLQLLRLRNN--Y 643 Query: 315 STTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRDV 374 ++ L NL L L+ ++ SL L+ L + N++ +P F Sbjct: 644 LAFFNWSSLTLLPNLETLDLAGNQLKALSNGSLPSGTQLQRLDVSRNSIIFVVPGFFALA 703 Query: 375 KHLSELRLNDNSL 387 L EL L+ N+L Sbjct: 704 TRLRELNLSANAL 716 Score = 48.9 bits (115), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 78/278 (28%), Positives = 119/278 (42%), Gaps = 47/278 (16%) Query: 179 LGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSIP-----GFVLPALSV 233 L L L+ L L N +N + F F GLR +DLS NR++G++ G V V Sbjct: 366 LARLPMLQRLYLQMNFINQAQLGIFKDFPGLRYIDLSDNRISGAVEPVATTGEVDGGKKV 425 Query: 234 LDLNQNLLTGPV--PPT---LTSCGSL-IKIDLSRNRVTGPIPESINRLNQLVLLDLSYN 287 +++L GP+ P + + SC +L +DLSRN + PE +L++L L LS+N Sbjct: 426 WLTSRDLTPGPLDTPSSEDFMPSCKNLSFTLDLSRNNLVTVQPEMFAQLSRLQCLRLSHN 485 Query: 288 RLSGPF-PSSLQGLNSLQALMLKGNT------KFSTTIPE-------------------- 320 +S S L SLQ L L N + T +P Sbjct: 486 SISQAVNGSQFVPLTSLQVLDLSHNKLDLYHGRSFTELPRLEALDLSYNSQPFSMRGVGH 545 Query: 321 --NAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLT-----GEIPLE-FR 372 + L L L L++ I + + L SL L GN+L+ G++ L F+ Sbjct: 546 NLSFVAQLPTLRYLSLAHNGIHSRVSQQLCS-TSLWALDFSGNSLSQMWAEGDLYLRFFQ 604 Query: 373 DVKHLSELRLNDNSLTGPVPFERDTVWRMRRKLRLYNN 410 ++ L L L+ N L +P + + + LRL NN Sbjct: 605 GLRSLIRLDLSQNRLHTLLPCTLGNLPKSLQLLRLRNN 642 Score = 41.6 bits (96), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 59/212 (27%), Positives = 96/212 (45%), Gaps = 33/212 (15%) Query: 181 NLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPGFVLPALSVLDLNQNL 240 N+T+L +L +HL+ S F + S L+ L+L N + P ++ Sbjct: 43 NVTSLSLLSNRIHHLHDS---DFAQLSNLQKLNLKWNCPPAGLSPMHFPCHMTIE----- 94 Query: 241 LTGPVPPTLTSCGSLIKIDLSRNRVTG--PIPESINRLNQLVLLDLSYNRLSGPFPSSLQ 298 P T + +L +++LS N +T +P S LV L LS + P+SL Sbjct: 95 -----PNTFLAVPTLEELNLSYNGITTVPALPSS------LVSLILSRTNILQLDPTSLT 143 Query: 299 GLNSLQALMLKGNTKF------STTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNS 352 GL++L+ L + GN + + + A GL NL L L N+ ++P+SL S Sbjct: 144 GLHALRFLYMDGNCYYKNPCGRALEVAPGALLGLGNLTHLSLKYNNLT-TVPRSLPP--S 200 Query: 353 LRVLHLEGNNLTGEIPLEFRDVKHLSELRLND 384 L L L N++ P D+ +L+ LR+ D Sbjct: 201 LEYLLLSYNHIVTLAP---EDLANLTALRVLD 229 Score = 37.0 bits (84), Expect = 0.020, Method: Compositional matrix adjust. Identities = 70/265 (26%), Positives = 102/265 (38%), Gaps = 54/265 (20%) Query: 140 YRCLGRAPQRIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKN-----H 194 Y L P+ +P SL+ L+L N + P++L NLT L+VLD+ N H Sbjct: 187 YNNLTTVPRSLPP-------SLEYLLLSYNHIVTLAPEDLANLTALRVLDVGGNCRRCDH 239 Query: 195 LNGSIPLSFNRFSGLRSLDLSGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGS 254 ++F L S S + G VL S+ LN G G+ Sbjct: 240 ARNPCVECPHKFPQLHSDTFSH---LSRLEGLVLKDSSLYQLNPRWFRG--------LGN 288 Query: 255 LIKIDLSRNRVTGPI--PESINRLNQLVLLDLSYNRLSG------PFPSSLQGLNSLQAL 306 L +DLS N + I ++ L QL L+LS+N S L SLQ L Sbjct: 289 LTVLDLSENFLYDCITKTKAFQGLAQLRRLNLSFNYHKKVSFAHLTLAPSFGSLLSLQEL 348 Query: 307 MLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGE 366 + G + LS +Q L RL L+ L+L+ N + Sbjct: 349 DMHG------------------IFFRSLSQKTLQ-----PLARLPMLQRLYLQMNFINQA 385 Query: 367 IPLEFRDVKHLSELRLNDNSLTGPV 391 F+D L + L+DN ++G V Sbjct: 386 QLGIFKDFPGLRYIDLSDNRISGAV 410 Score = 36.6 bits (83), Expect = 0.028, Method: Compositional matrix adjust. Identities = 70/233 (30%), Positives = 95/233 (40%), Gaps = 52/233 (22%) Query: 123 YVSESLTRLKHLKAL--------FFYRCLGRAPQRIPAFLGRLGSSLQTLVLRENGFLGP 174 Y S T L L+AL F R +G +F+ +L +L+ L L NG Sbjct: 515 YHGRSFTELPRLEALDLSYNSQPFSMRGVGHNL----SFVAQL-PTLRYLSLAHNGIHSR 569 Query: 175 IPDELGNLTNLKVLDLHKNHLN-----GSIPLSFNRFSGLRSL---DLSGNRLTGSIP-- 224 + +L + T+L LD N L+ G + L F F GLRSL DLS NRL +P Sbjct: 570 VSQQLCS-TSLWALDFSGNSLSQMWAEGDLYLRF--FQGLRSLIRLDLSQNRLHTLLPCT 626 Query: 225 ------------------GF-------VLPALSVLDLNQNLLTGPVPPTLTSCGSLIKID 259 F +LP L LDL N L +L S L ++D Sbjct: 627 LGNLPKSLQLLRLRNNYLAFFNWSSLTLLPNLETLDLAGNQLKALSNGSLPSGTQLQRLD 686 Query: 260 LSRNRVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGL-NSLQALMLKGN 311 +SRN + +P +L L+LS N L PS L SL+ L + N Sbjct: 687 VSRNSIIFVVPGFFALATRLRELNLSANALRTVEPSWFGFLAGSLEVLDVSAN 739 Score = 33.9 bits (76), Expect = 0.19, Method: Compositional matrix adjust. Identities = 57/189 (30%), Positives = 80/189 (42%), Gaps = 27/189 (14%) Query: 294 PSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSL 353 P++ + +L+ L L N TT+P +L+ L+LS TNI P SLT L++L Sbjct: 95 PNTFLAVPTLEELNLSYNGI--TTVPALP----SSLVSLILSRTNILQLDPTSLTGLHAL 148 Query: 354 RVLHLEGN----NLTGE----IPLEFRDVKHLSELRLNDNSLTGPVPFERDTVWRMRRKL 405 R L+++GN N G P + +L+ L L N+LT VP R + L Sbjct: 149 RFLYMDGNCYYKNPCGRALEVAPGALLGLGNLTHLSLKYNNLTT-VP--RSLPPSLEYLL 205 Query: 406 RLYNNAGLCVNRD-SDLDDAFGSKSGSTVRLCD------AETSRPAP---SGTVQHLSRE 455 YN+ D ++L G R CD E P S T HLSR Sbjct: 206 LSYNHIVTLAPEDLANLTALRVLDVGGNCRRCDHARNPCVECPHKFPQLHSDTFSHLSRL 265 Query: 456 EDGALPDGA 464 E L D + Sbjct: 266 EGLVLKDSS 274 >3ULU-A nrPDB Length = 694 Score = 51.6 bits (122), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 41/122 (33%), Positives = 59/122 (48%), Gaps = 4/122 (3%) Query: 172 LGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPGFV--LP 229 L +PD+L TN+ VL+L N L +F R+S L SLD+ N ++ P LP Sbjct: 26 LTQVPDDLP--TNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNTISKLEPELCQKLP 83 Query: 230 ALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRL 289 L VL+L N L+ T C +L ++ L N + + L+ LDLS+N L Sbjct: 84 MLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQKNLITLDLSHNGL 143 Query: 290 SG 291 S Sbjct: 144 SS 145 Score = 42.4 bits (98), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 75/305 (24%), Positives = 122/305 (40%), Gaps = 43/305 (14%) Query: 60 DAVYDIMRATGNDWAAAIPDVCRGRWHGIECMPDQDNVYHVVSLSFGALSDDTAFPTCDP 119 D Y+ + GND A +P + + +E +N+ H+ S S L + + Sbjct: 264 DLSYNNLNVVGNDSFAWLPQL---EYFFLE----YNNIQHLFSHSLHGLFNVRYL---NL 313 Query: 120 QRSYVSESLTRLKHLKALFFYRCLGRAPQRIPAFLGRLGSSLQTLVLRENGFLGPIPDEL 179 +RS+ +S++ L P +I F + L+ L + +N G + Sbjct: 314 KRSFTKQSIS-------------LASLP-KIDDFSFQWLKCLEHLNMEDNDIPGIKSNMF 359 Query: 180 GNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPGFVLPALSVLDLNQN 239 L NLK L L N F+ LR+L + L +L+L +N Sbjct: 360 TGLINLKYLSLS------------NSFTSLRTLT------NETFVSLAHSPLHILNLTKN 401 Query: 240 LLTGPVPPTLTSCGSLIKIDLSRNRVTGPIP-ESINRLNQLVLLDLSYNRLSGPFPSSLQ 298 ++ + G L +DL N + + + L + + LSYN+ +S Sbjct: 402 KISKIESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKYLQLTRNSFA 461 Query: 299 GLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHL 358 + SLQ LML+ + + F+ L+NL IL LSN NI L L L +L L Sbjct: 462 LVPSLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEGLEKLEILDL 521 Query: 359 EGNNL 363 + NNL Sbjct: 522 QHNNL 526 Score = 34.3 bits (77), Expect = 0.13, Method: Compositional matrix adjust. Identities = 42/126 (33%), Positives = 58/126 (46%), Gaps = 14/126 (11%) Query: 151 PAFLGRLGSSLQTLVLRENGFLGPIPDEL-GNLTNLKVLDLHKNHLNGSIPLS-FNRFSG 208 P + + S L L L NGF IP E+ +L LK++DL N+LN ++P S FN Sbjct: 538 PIYFLKGLSHLHILNLESNGF-DEIPVEVFKDLFELKIIDLGLNNLN-TLPASVFNNQVS 595 Query: 209 LRSLDLSGNRLTGSIPGFVLPA---LSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRV 265 L+SL+L N +T PA L+ LD+ N P +C S+ N Sbjct: 596 LKSLNLQKNLITSVEKKVFGPAFRNLTELDMRFN-------PFDCTCESIAWFVNWINET 648 Query: 266 TGPIPE 271 IPE Sbjct: 649 HTNIPE 654 Score = 31.2 bits (69), Expect = 0.95, Method: Compositional matrix adjust. Identities = 36/112 (32%), Positives = 54/112 (48%), Gaps = 7/112 (6%) Query: 254 SLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGN-T 312 +L +DLS N + +S L QL L YN + F SL GL +++ L LK + T Sbjct: 259 NLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSFT 318 Query: 313 KFSTT------IPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHL 358 K S + I + +F+ LK L L + + +I G T L +L+ L L Sbjct: 319 KQSISLASLPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSL 370 Score = 29.3 bits (64), Expect = 3.8, Method: Compositional matrix adjust. Identities = 66/232 (28%), Positives = 104/232 (44%), Gaps = 25/232 (10%) Query: 152 AFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRS 211 F+ S L L L +N D L +L+VLDL N + L+ + GL + Sbjct: 384 TFVSLAHSPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQE--LTGQEWRGLEN 441 Query: 212 L---DLSGNR-LTGSIPGFVL-PALSVLDLN----QNLLTGPVPPTLTSCGSLIKIDLSR 262 + LS N+ L + F L P+L L L +N+ + P P +L +DLS Sbjct: 442 IFEIYLSYNKYLQLTRNSFALVPSLQRLMLRRVALKNVDSSPSP--FQPLRNLTILDLSN 499 Query: 263 NRVTGPIPESINRLNQLVLLDLSYNRLSGPFPSS--------LQGLNSLQALMLKGNTKF 314 N + + + L +L +LDL +N L+ + + L+GL+ L L L+ N Sbjct: 500 NNIANINDDMLEGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHILNLESNG-- 557 Query: 315 STTIPENAFKGLKNLMILVLSNTNIQGSIPKSL-TRLNSLRVLHLEGNNLTG 365 IP FK L L I+ L N+ ++P S+ SL+ L+L+ N +T Sbjct: 558 FDEIPVEVFKDLFELKIIDLGLNNL-NTLPASVFNNQVSLKSLNLQKNLITS 608 Score = 28.9 bits (63), Expect = 5.1, Method: Compositional matrix adjust. Identities = 65/251 (25%), Positives = 103/251 (41%), Gaps = 22/251 (8%) Query: 148 QRIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFS 207 +R+PA S L +L + N P+ L LKVL+L N L+ +F + Sbjct: 48 RRLPAANFTRYSQLTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNELSQLSDKTFAFCT 107 Query: 208 GLRSLDLSGNRLT--GSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRV 265 L L L N + + P L LDL+ N L+ T +L ++ LS N++ Sbjct: 108 NLTELHLMSNSIQKIKNNPFVKQKNLITLDLSHNGLSSTKLGTQVQLENLQELLLSNNKI 167 Query: 266 TGPIPESINRL--NQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAF 323 E ++ + L L+LS N++ P + L L L N + ++ E Sbjct: 168 QALKSEELDIFANSSLKKLELSSNQIKEFSPGCFHAIGRLFGLFL-NNVQLGPSLTEKLC 226 Query: 324 KGLKNLMILVLSNTNIQGSIPKSLT----RLNSLRVLHLEGNNLT-------GEIP---- 368 L N I LS +N Q S + T + +L +L L NNL +P Sbjct: 227 LELANTSIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEY 286 Query: 369 --LEFRDVKHL 377 LE+ +++HL Sbjct: 287 FFLEYNNIQHL 297 >4R6F-A nrPDB Length = 331 Score = 51.6 bits (122), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 78/262 (29%), Positives = 108/262 (41%), Gaps = 68/262 (25%) Query: 179 LGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPGFVLPALSVLDLNQ 238 L LTNL L+L N L F + + L +L+LS N+LT S+P V L+ Sbjct: 81 LKELTNLGWLNLSNNQLETLPQGVFEKLTNLTTLNLSNNQLT-SLPQGVFERLA------ 133 Query: 239 NLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSGPFPSS-- 296 SL ++LS N + + + L L L+LS+N L+ + + Sbjct: 134 ---------------SLTTLNLSNNNIANINDQMLEGLTNLTTLNLSHNNLARLWKHANP 178 Query: 297 ------LQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRL 350 L+GL +L L L N F IP FK L +L L LSN NI + L L Sbjct: 179 GGPIYFLKGLTNLTTLNLSSN-GFD-EIPREVFKDLTSLTTLNLSNNNIANINDQMLEGL 236 Query: 351 NSLRVLHLEGNNLT-------------------------------GEIPLE-FRDVKHLS 378 +L L+L NNL EIP E F+D+ L+ Sbjct: 237 TNLTTLNLSHNNLARLWKHANPGGPIYFLKGLTNLTTLNLSSNGFDEIPREVFKDLTSLT 296 Query: 379 ELRLNDNSLTGPVP---FERDT 397 L L++N LT +P FER T Sbjct: 297 TLNLSNNQLTS-LPQGVFERLT 317 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 67/226 (29%), Positives = 99/226 (43%), Gaps = 48/226 (21%) Query: 182 LTNLKVLDLHKNHLNGSIPLS-FNRFSGLRSLDLSGNRLTGSIPGFV--LPALSVLDLNQ 238 LTNL L+L N L S+P F R + L +L+LS N + + L L+ L+L+ Sbjct: 108 LTNLTTLNLSNNQL-TSLPQGVFERLASLTTLNLSNNNIANINDQMLEGLTNLTTLNLSH 166 Query: 239 NLLT---------GPV----------PPTLTSCG-------------SLIKIDLSRNRVT 266 N L GP+ L+S G SL ++LS N + Sbjct: 167 NNLARLWKHANPGGPIYFLKGLTNLTTLNLSSNGFDEIPREVFKDLTSLTTLNLSNNNIA 226 Query: 267 GPIPESINRLNQLVLLDLSYNRLSGPFPSS--------LQGLNSLQALMLKGNTKFSTTI 318 + + L L L+LS+N L+ + + L+GL +L L L N F I Sbjct: 227 NINDQMLEGLTNLTTLNLSHNNLARLWKHANPGGPIYFLKGLTNLTTLNLSSN-GFDE-I 284 Query: 319 PENAFKGLKNLMILVLSNTNIQGSIPKSL-TRLNSLRVLHLEGNNL 363 P FK L +L L LSN + S+P+ + RL +L+ L+L N L Sbjct: 285 PREVFKDLTSLTTLNLSNNQLT-SLPQGVFERLTNLKTLNLSNNQL 329 Score = 32.0 bits (71), Expect = 0.59, Method: Compositional matrix adjust. Identities = 35/109 (32%), Positives = 53/109 (48%), Gaps = 13/109 (11%) Query: 295 SSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSL-TRLNSL 353 S+L+ L +L L L N T+P+ F+ L NL L LSN + S+P+ + RL SL Sbjct: 79 SALKELTNLGWLNLSNNQL--ETLPQGVFEKLTNLTTLNLSNNQLT-SLPQGVFERLASL 135 Query: 354 RVLHLEGNNLTGEIPLEFRDVKHLSELRLNDNSLT---------GPVPF 393 L+L NN+ + +L+ L L+ N+L GP+ F Sbjct: 136 TTLNLSNNNIANINDQMLEGLTNLTTLNLSHNNLARLWKHANPGGPIYF 184 >3WPI-A nrPDB Length = 803 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 84/307 (27%), Positives = 131/307 (42%), Gaps = 59/307 (19%) Query: 100 VVSLSFGALSDDTAFPTCDPQRSYVSESLTRLKHLKALFFYRCLGRAPQRIPAFLGRLGS 159 +V LS LS++ + + ++ ++LTRL+ L F YR +++ L S Sbjct: 286 LVQLSVLDLSENFLYESITHTNAF--QNLTRLRKLNLSFNYR------KKVSFARLHLAS 337 Query: 160 SLQTLV----LRENGFLGPIPDE-----LGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLR 210 S + LV L NG + ++ L +L L L L N +N + F F LR Sbjct: 338 SFKNLVSLQELNMNGIFFRLLNKYTLRWLADLPKLHTLHLQMNFINQAQLSIFGTFRALR 397 Query: 211 SLDLSGNRLTG-SIPGFVLPALSVLDLNQNLLTG-PVPPTLTS---------CGSL-IKI 258 +DLS NR++G S P + + LL+ P P L++ C + + Sbjct: 398 FVDLSDNRISGPSTLSEATPEEADDAEQEELLSADPHPAPLSTPASKNFMDRCKNFKFTM 457 Query: 259 DLSRNRVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTI 318 DLSRN + PE +L++L L LS+N ++ Q +N Q Sbjct: 458 DLSRNNLVTIKPEMFVQLSRLQCLSLSHNSIA-------QAVNGSQ-------------- 496 Query: 319 PENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGN----NLTGEIPLEFRDV 374 F L NL +L LS+ + KS + L L+ L L N ++ G I +F V Sbjct: 497 ----FLPLTNLQVLDLSHNKLDLYHWKSFSELPQLQALDLSYNSQPFSMKG-IGHQFSFV 551 Query: 375 KHLSELR 381 HLS L+ Sbjct: 552 THLSMLQ 558 Score = 38.5 bits (88), Expect = 0.007, Method: Compositional matrix adjust. Identities = 60/204 (29%), Positives = 83/204 (40%), Gaps = 25/204 (12%) Query: 156 RLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDL-----HKNHLNGSI---PLSFNRFS 207 RL SSL L L L + L L +L+VL + +KN G++ P + S Sbjct: 119 RLPSSLVNLSLSHTNILVLDANSLAGLYSLRVLFMDGNCYYKNPCTGAVKVTPGALLGLS 178 Query: 208 GLRSLDLSGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRN---- 263 L L L N LT +P + P+L L ++ NL+ P L SL +D+ N Sbjct: 179 QLTHLSLKYNNLT-KVPRQLPPSLEYLLVSYNLIVKLGPEDLAQLTSLRVLDVGGNCRRC 237 Query: 264 -RVTGPI-----------PESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGN 311 P PE+ + L+ L L L + L S QGL L L L N Sbjct: 238 DHAPNPCIECGQKSLHLHPETFHHLSHLEGLVLKDSSLHTLNSSWFQGLVQLSVLDLSEN 297 Query: 312 TKFSTTIPENAFKGLKNLMILVLS 335 + + NAF+ L L L LS Sbjct: 298 FLYESITHTNAFQNLTRLRKLNLS 321 Score = 31.2 bits (69), Expect = 1.2, Method: Compositional matrix adjust. Identities = 82/314 (26%), Positives = 120/314 (38%), Gaps = 54/314 (17%) Query: 221 GSIPGFV---LPALSVLDLNQNLLTG-PVPPTLTSCGSLIKIDLSRNRVTGPIPESINRL 276 G++P F+ L ++D N L P SC ++ ++ L NR+ L Sbjct: 6 GTLPAFLPCELKPHGLVDCNWLFLKSVPRFSAAASCSNITRLSLISNRIHHLHNSDFVHL 65 Query: 277 NQLVLLDLSYN---------RLSGPF---PSSLQGLNSLQALMLKGNTKFSTTIPENAFK 324 + L L+L +N S P + + +L+ L L N TT+P Sbjct: 66 SNLRQLNLKWNCPPTGLSPLHFSCHMTIEPRTFLAMRTLEELNLSYNGI--TTVPRLP-- 121 Query: 325 GLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNL-----TGEI---PLEFRDVKH 376 +L+ L LS+TNI SL L SLRVL ++GN TG + P + Sbjct: 122 --SSLVNLSLSHTNILVLDANSLAGLYSLRVLFMDGNCYYKNPCTGAVKVTPGALLGLSQ 179 Query: 377 LSELRLNDNSLTG-----PVPFERDTV-WRMRRKLRLYNNAGLCVNRDSDLDDAFGSKSG 430 L+ L L N+LT P E V + + KL + A L R D+ G Sbjct: 180 LTHLSLKYNNLTKVPRQLPPSLEYLLVSYNLIVKLGPEDLAQLTSLRVLDV--------G 231 Query: 431 STVRLCDAETSRPAPSG---------TVQHLSREEDGALPDGATDVSSTSKSLGFSYLSA 481 R CD + G T HLS E L D + ++S G LS Sbjct: 232 GNCRRCDHAPNPCIECGQKSLHLHPETFHHLSHLEGLVLKDSSLHTLNSSWFQGLVQLSV 291 Query: 482 FFLVFPNFIFMLIS 495 L NF++ I+ Sbjct: 292 LDLS-ENFLYESIT 304 >2Z80-A nrPDB Length = 353 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 50/163 (30%), Positives = 76/163 (46%), Gaps = 2/163 (1%) Query: 222 SIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVL 281 SIP + A+ LDL+ N +T L C +L + L+ N + +S + L L Sbjct: 45 SIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEH 104 Query: 282 LDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQG 341 LDLSYN LS S + L+SL L L GN + T + F L L IL + N + Sbjct: 105 LDLSYNYLSNLSSSWFKPLSSLTFLNLLGN-PYKTLGETSLFSHLTKLQILRVGNMDTFT 163 Query: 342 SIP-KSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLN 383 I K L L L ++ ++L P + ++++S L L+ Sbjct: 164 KIQRKDFAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILH 206 Score = 29.3 bits (64), Expect = 3.7, Method: Compositional matrix adjust. Identities = 22/57 (38%), Positives = 28/57 (49%) Query: 161 LQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGN 217 LQ LVL NG D +L +L+ LDL N+L+ F S L L+L GN Sbjct: 78 LQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGN 134 >2Z7X-A nrPDB Length = 549 Score = 49.7 bits (117), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 50/164 (30%), Positives = 76/164 (46%), Gaps = 2/164 (1%) Query: 221 GSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLV 280 SIP + A+ LDL+ N +T L C +L + L+ N + +S + L L Sbjct: 18 NSIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLE 77 Query: 281 LLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQ 340 LDLSYN LS S + L+SL L L GN + T + F L L IL + N + Sbjct: 78 HLDLSYNYLSNLSSSWFKPLSSLTFLNLLGN-PYKTLGETSLFSHLTKLQILRVGNMDTF 136 Query: 341 GSIP-KSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLN 383 I K L L L ++ ++L P + ++++S L L+ Sbjct: 137 TKIQRKDFAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILH 180 Score = 37.7 bits (86), Expect = 0.012, Method: Compositional matrix adjust. Identities = 46/154 (29%), Positives = 77/154 (50%), Gaps = 10/154 (6%) Query: 160 SLQTLVLRENGF--LGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGN 217 SLQTL+LR+N L + L L NL +D+ KN + S+P + ++ L+LS Sbjct: 362 SLQTLILRQNHLASLEKTGETLLTLKNLTNIDISKNSFH-SMPETCQWPEKMKYLNLSST 420 Query: 218 RLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINRLN 277 R+ S+ G + L +LD++ N L L ++ +SRN++ +P++ + L Sbjct: 421 RI-HSVTGCIPKTLEILDVSNNNLNLFSLNL----PQLKELYISRNKLM-TLPDA-SLLP 473 Query: 278 QLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGN 311 L++L +S N+L L SLQ + L N Sbjct: 474 MLLVLKISRNQLKSVPDGIFDRLTSLQKIWLHTN 507 Score = 29.3 bits (64), Expect = 4.2, Method: Compositional matrix adjust. Identities = 22/57 (38%), Positives = 28/57 (49%) Query: 161 LQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGN 217 LQ LVL NG D +L +L+ LDL N+L+ F S L L+L GN Sbjct: 52 LQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGN 108 >6GFF-I nrPDB Length = 618 Score = 48.9 bits (115), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 88/300 (29%), Positives = 115/300 (38%), Gaps = 65/300 (21%) Query: 138 FFYRCLGRAPQRIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNG 197 R LG AP SL TL L EN ++ L+ LDLH N L Sbjct: 121 LLERLLGEAP------------SLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMD 168 Query: 198 SIPLSFNRFSGLRSLDLSGNRLTGSIPGFVLPALSVLDLNQNLL----TGPVP------- 246 +F L L+LS N LT I F L L VLDL+ N + T P Sbjct: 169 IEDGAFEGLPRLTHLNLSRNSLT-CISDFSLQQLRVLDLSCNSIEAFQTASQPQAEFQLT 227 Query: 247 ------------PTLTSCGSLIKIDLSRNRV---TGPIPESIN----------------- 274 P L + LI ++LS N + TGP +S Sbjct: 228 WLDLRENKLLHFPDLAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPS 287 Query: 275 ------RLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKN 328 L+QL+ LDLSYN + S L+ L SL L L N T L Sbjct: 288 GNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCL--RTFEARRLGSLPC 345 Query: 329 LMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLNDNSLT 388 LM+L LS+ ++ ++ L SLR L L+GN L P F ++ L L L N ++ Sbjct: 346 LMLLDLSHNALE-TLELGARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVS 404 Score = 38.5 bits (88), Expect = 0.007, Method: Compositional matrix adjust. Identities = 47/169 (27%), Positives = 73/169 (43%), Gaps = 4/169 (2%) Query: 223 IPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLL 282 +P + P LDL+ N L + L +L +DLS N ++ P + L L L Sbjct: 24 VPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHL 83 Query: 283 DLSYNRLSGPFPSSLQGLNSL---QALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNI 339 L++NRL+ S GL L +L L GN+ +S + E +L L L+ ++ Sbjct: 84 SLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLL-ERLLGEAPSLHTLSLAENSL 142 Query: 340 QGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLNDNSLT 388 + + +L L L N L F + L+ L L+ NSLT Sbjct: 143 TRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLT 191 Score = 36.6 bits (83), Expect = 0.024, Method: Compositional matrix adjust. Identities = 56/186 (30%), Positives = 84/186 (45%), Gaps = 11/186 (5%) Query: 162 QTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRL-- 219 +TL L N + LG T L+ LDL N ++ P +F + L L L+ NRL Sbjct: 33 ETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAM 92 Query: 220 -TGSIPGFV--LPALSVLDLNQN-LLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINR 275 T G + LP ++ LDL+ N L +G + L SL + L+ N +T + Sbjct: 93 ATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRD 152 Query: 276 LNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLS 335 + L LDL N L + +GL L L L N+ T I + + L+ L +L LS Sbjct: 153 MPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSL--TCISDFS---LQQLRVLDLS 207 Query: 336 NTNIQG 341 +I+ Sbjct: 208 CNSIEA 213 >1XCD-A nrPDB Length = 329 Score = 48.1 bits (113), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 62/228 (27%), Positives = 97/228 (42%), Gaps = 31/228 (13%) Query: 187 VLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPGFVLP--ALSVLDLNQNLLTGP 244 +LDL N + F L +L L N+++ PG P L L L++N L Sbjct: 56 LLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQLK-E 114 Query: 245 VPPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRL--SGPFPSSLQGLN- 301 +P + +L ++ + N +T N LNQ+++++L N L SG + QG+ Sbjct: 115 LPEKMPK--TLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQGMKK 172 Query: 302 --------------------SLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQG 341 SL L L GN T + + KGL NL L LS +I Sbjct: 173 LSYIRIADTNITTIPQGLPPSLTELHLDGNK--ITKVDAASLKGLNNLAKLGLSFNSISA 230 Query: 342 SIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLNDNSLTG 389 SL LR LHL N L ++P D K++ + L++N+++ Sbjct: 231 VDNGSLANTPHLRELHLNNNKLV-KVPGGLADHKYIQVVYLHNNNISA 277 Score = 38.5 bits (88), Expect = 0.006, Method: Compositional matrix adjust. Identities = 32/84 (38%), Positives = 43/84 (51%), Gaps = 4/84 (4%) Query: 305 ALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLT 364 AL+ N K T I + FK LKNL L+L N I P + L L L+L N L Sbjct: 55 ALLDLQNNKI-TEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQLK 113 Query: 365 GEIPLEFRDVKHLSELRLNDNSLT 388 E+P + K L ELR+++N +T Sbjct: 114 -ELPEKMP--KTLQELRVHENEIT 134 Score = 33.9 bits (76), Expect = 0.18, Method: Compositional matrix adjust. Identities = 48/187 (25%), Positives = 80/187 (42%), Gaps = 19/187 (10%) Query: 160 SLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRL 219 L+ L L +N L +P+++ L+ L +H+N + FN + + ++L N L Sbjct: 101 KLERLYLSKNQ-LKELPEKMP--KTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPL 157 Query: 220 ------TGSIPGFV-LPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPES 272 G+ G L + + D N + +PP+LT ++ L N++T S Sbjct: 158 KSSGIENGAFQGMKKLSYIRIADTNITTIPQGLPPSLT------ELHLDGNKITKVDAAS 211 Query: 273 INRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMIL 332 + LN L L LS+N +S SL L+ L L N +P K + ++ Sbjct: 212 LKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLNNNK--LVKVP-GGLADHKYIQVV 268 Query: 333 VLSNTNI 339 L N NI Sbjct: 269 YLHNNNI 275 >5ZSN-B nrPDB Length = 823 Score = 48.1 bits (113), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 48/143 (33%), Positives = 66/143 (46%), Gaps = 18/143 (12%) Query: 228 LPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYN 287 L L VL L N +T VP L S +L ++ L N + + N LNQL +LDLS N Sbjct: 181 LTKLKVLSLKDNNVTT-VPTVLPS--TLTELYLYNNMIAEIQEDDFNNLNQLQILDLSGN 237 Query: 288 R---LSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIP 344 + PFP + K N+ IP NAF L L +L L + ++Q P Sbjct: 238 CPRCYNAPFPCT----------PCKNNSPLQ--IPVNAFDALTELKVLRLHSNSLQHVPP 285 Query: 345 KSLTRLNSLRVLHLEGNNLTGEI 367 + +N+L+ L L N L EI Sbjct: 286 RWFKNINNLQELDLSQNFLAKEI 308 Score = 39.7 bits (91), Expect = 0.003, Method: Compositional matrix adjust. Identities = 71/260 (27%), Positives = 109/260 (41%), Gaps = 35/260 (13%) Query: 154 LGRLGSSLQTL-VLRENGF---------LGPIPDELGNLTNLKVLDLHKNHLNGSIPLSF 203 L + SSL++L +LR G+ L P L NL NL+VLDL N + + F Sbjct: 340 LSQAFSSLKSLKILRIRGYVFKELKSFQLSP----LHNLQNLEVLDLGTNFIKIANLSMF 395 Query: 204 NRFSGLRSLDLSGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLS-- 261 +F L+ +DLS N+++ S V S N P + + D Sbjct: 396 KQFKRLKVIDLSVNKISPSGDSLVPRGSS----NARTSVESYEPQVLEQLYYFRYDKYAR 451 Query: 262 ----RNRVTG--PIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFS 315 +N+ + ES + Q LDLS N + S Q L+ L+ L L GN S Sbjct: 452 SCRFKNKEASFTSVQESCYKYGQ--TLDLSKNSIFFIKSSDFQHLSFLKCLNLSGNL-IS 508 Query: 316 TTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIP-----LE 370 T+ + F+ L L L SN + + L L VL + N+ + L Sbjct: 509 QTLNGSEFQPLAELRYLDFSNNRLDLLHSTAFEELRKLEVLDISSNSHYFQSEGITHMLN 568 Query: 371 F-RDVKHLSELRLNDNSLTG 389 F +++K L +L +NDN ++ Sbjct: 569 FTKNLKVLQKLMMNDNDISS 588 Score = 36.6 bits (83), Expect = 0.027, Method: Compositional matrix adjust. Identities = 50/168 (29%), Positives = 68/168 (40%), Gaps = 27/168 (16%) Query: 182 LTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSI--PGFV--LPALSVLDLN 237 LT LKVL LH N L P F + L+ LDLS N L I F+ LP L LDL+ Sbjct: 267 LTELKVLRLHSNSLQHVPPRWFKNINNLQELDLSQNFLAKEIGDAKFLHFLPNLIQLDLS 326 Query: 238 QNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLLDLS---YNRLSGPFP 294 N +L R + + ++ + L L +L + + L Sbjct: 327 FNF------------------ELQVYRASMNLSQAFSSLKSLKILRIRGYVFKELKSFQL 368 Query: 295 SSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGS 342 S L L +L+ L L T F + FK K L ++ LS I S Sbjct: 369 SPLHNLQNLEVLDL--GTNFIKIANLSMFKQFKRLKVIDLSVNKISPS 414 Score = 32.7 bits (73), Expect = 0.35, Method: Compositional matrix adjust. Identities = 52/210 (24%), Positives = 84/210 (40%), Gaps = 49/210 (23%) Query: 186 KVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPGFVLPALSVLDLNQNLLTGPV 245 + LDL KN + F S L+ L+LSGN ++ ++ G L Sbjct: 474 QTLDLSKNSIFFIKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPL-------------- 519 Query: 246 PPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQA 305 L +D S NR+ + L +L +LD+S N S F S +G+ + Sbjct: 520 -------AELRYLDFSNNRLDLLHSTAFEELRKLEVLDISSN--SHYFQS--EGITHML- 567 Query: 306 LMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNL-- 363 N K LK L L++++ +I S +++ SLR L GN+L Sbjct: 568 ---------------NFTKNLKVLQKLMMNDNDISSSTSRTMES-ESLRTLEFRGNHLDV 611 Query: 364 -----TGEIPLEFRDVKHLSELRLNDNSLT 388 F+++ L EL ++ NSL+ Sbjct: 612 LWRDGDNRYLQLFKNLLKLEELDISKNSLS 641 Score = 30.4 bits (67), Expect = 1.8, Method: Compositional matrix adjust. Identities = 28/83 (33%), Positives = 43/83 (51%), Gaps = 4/83 (4%) Query: 160 SLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFS-GLRSLDLSGNR 218 +L+ L L +NG I ++L L NL+ LDL N L ++P + S L++L L N+ Sbjct: 654 NLKNLSLAKNGLKSFIWEKLRYLKNLETLDLSHNQL-TTVPERLSNCSRSLKNLILKNNQ 712 Query: 219 LTGSIPGFVLPA--LSVLDLNQN 239 + F+ A L LDL+ N Sbjct: 713 IRSLTKYFLQDAFQLRYLDLSSN 735 Score = 30.0 bits (66), Expect = 2.2, Method: Compositional matrix adjust. Identities = 30/102 (29%), Positives = 45/102 (44%), Gaps = 7/102 (6%) Query: 121 RSYVSESLTRLKHLKAL-FFYRCLGRAPQRIPAFLGRLGSSLQTLVLRENGFLGPIPDEL 179 +S++ E L LK+L+ L + L P+R L SL+ L+L+ N L Sbjct: 666 KSFIWEKLRYLKNLETLDLSHNQLTTVPER----LSNCSRSLKNLILKNNQIRSLTKYFL 721 Query: 180 GNLTNLKVLDLHKNHLNGSIPLSF--NRFSGLRSLDLSGNRL 219 + L+ LDL N + SF N + L+ L L NR Sbjct: 722 QDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLLHHNRF 763 Score = 28.1 bits (61), Expect = 9.9, Method: Compositional matrix adjust. Identities = 55/214 (25%), Positives = 81/214 (37%), Gaps = 63/214 (29%) Query: 161 LQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHL--------NGSIPLSFNRFSGLRSL 212 LQ L++ +N + + +L+ L+ NHL N + L F L L Sbjct: 576 LQKLMMNDNDISSSTSRTMES-ESLRTLEFRGNHLDVLWRDGDNRYLQL-FKNLLKLEEL 633 Query: 213 DLSGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPES 272 D+S N L+ LP+ V D +PP L + + L++N + I E Sbjct: 634 DISKNSLS------FLPS-GVFD--------GMPPNLKN------LSLAKNGLKSFIWEK 672 Query: 273 INRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPE---NAFKGLKNL 329 + L L LDLS+N+L TT+PE N + LKNL Sbjct: 673 LRYLKNLETLDLSHNQL--------------------------TTVPERLSNCSRSLKNL 706 Query: 330 MILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNL 363 +L N I+ L LR L L N + Sbjct: 707 ---ILKNNQIRSLTKYFLQDAFQLRYLDLSSNKI 737 >5D3I-A nrPDB Length = 568 Score = 48.1 bits (113), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 55/177 (31%), Positives = 77/177 (43%), Gaps = 10/177 (5%) Query: 211 SLDLSG-----NRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRV 265 S D SG +R SIP + A+ LDL+ N +T L +C +L + L +R+ Sbjct: 7 SCDASGVCDGRSRSFTSIPSGLTAAMKSLDLSFNKITYIGHGDLRACANLQVLILKSSRI 66 Query: 266 TGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKG 325 ++ L L LDLS N LS S L+SL+ L L GN + T + F Sbjct: 67 NTIEGDAFYSLGSLEHLDLSDNHLSSLSSSWFGPLSSLKYLNLMGN-PYQTLGVTSLFPN 125 Query: 326 LKNLMILVLSNTNIQGSIPK----SLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLS 378 L NL L + N I + LT LN L + L N + RD+ HL+ Sbjct: 126 LTNLQTLRIGNVETFSEIRRIDFAGLTSLNELEIKALSLRNYQSQSLKSIRDIHHLT 182 Score = 29.6 bits (65), Expect = 2.8, Method: Compositional matrix adjust. Identities = 21/62 (33%), Positives = 32/62 (51%) Query: 156 RLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLS 215 R ++LQ L+L+ + D +L +L+ LDL NHL+ F S L+ L+L Sbjct: 51 RACANLQVLILKSSRINTIEGDAFYSLGSLEHLDLSDNHLSSLSSSWFGPLSSLKYLNLM 110 Query: 216 GN 217 GN Sbjct: 111 GN 112 >3J0A-A nrPDB Length = 844 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 70/231 (30%), Positives = 101/231 (43%), Gaps = 46/231 (19%) Query: 128 LTRLKHLKALF-----FYRCLG-RAPQRIPAFLGRLGSSLQTLVLRENGFLGPIPDELG- 180 L R+ HL+ L F C G + P P SL+ L L EN EL Sbjct: 422 LLRVPHLQILILNQNRFSSCSGDQTPSENP--------SLEQLFLGENMLQLAWETELCW 473 Query: 181 ----NLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPGFVLPA-LSVLD 235 L++L+VL L+ N+LN P F+ + LR L L+ NRLT + LPA L +LD Sbjct: 474 DVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLT-VLSHNDLPANLEILD 532 Query: 236 LNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPES--INRLNQLVLLDLSYNRLSGP- 292 +++N L P P S L D++ N+ S IN LN + ++GP Sbjct: 533 ISRNQLLAPNPDVFVSLSVL---DITHNKFICECELSTFINWLNHTNV------TIAGPP 583 Query: 293 ------FPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNT 337 +P S G+ SL +L +G + E K LK + +V + T Sbjct: 584 ADIYCVYPDSFSGV-SLFSLSTEGCDE------EEVLKSLKFSLFIVCTVT 627 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 72/252 (28%), Positives = 104/252 (41%), Gaps = 28/252 (11%) Query: 152 AFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRS 211 AF G +LQ L L N L + +DL KNH+ +F L++ Sbjct: 309 AFYGL--DNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQT 366 Query: 212 LDLSGNRLTG-----SIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVT 266 LDL N LT SIP L ++ L P + +LI LS NR+ Sbjct: 367 LDLRDNALTTIHFIPSIPDIFLSGNKLVTL----------PKINLTANLIH--LSENRLE 414 Query: 267 G-PIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLN-SLQALMLKGNT---KFSTTIPEN 321 I + R+ L +L L+ NR S N SL+ L L N + T + + Sbjct: 415 NLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWD 474 Query: 322 AFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRDV-KHLSEL 380 F+GL +L +L L++ + P + L +LR L L N LT L D+ +L L Sbjct: 475 VFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLT---VLSHNDLPANLEIL 531 Query: 381 RLNDNSLTGPVP 392 ++ N L P P Sbjct: 532 DISRNQLLAPNP 543 Score = 37.0 bits (84), Expect = 0.020, Method: Compositional matrix adjust. Identities = 46/185 (24%), Positives = 77/185 (41%), Gaps = 18/185 (9%) Query: 221 GSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLV 280 + G ++ LDL+ + + L ++L+ N++ E+ L+ L Sbjct: 258 NTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQ 317 Query: 281 LLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMIL-----VLS 335 +L+LSYN L + S+ GL + + L+ N I + FK L+ L L L+ Sbjct: 318 VLNLSYNLLGELYSSNFYGLPKVAYIDLQKNH--IAIIQDQTFKFLEKLQTLDLRDNALT 375 Query: 336 NTNIQGSIPK---------SLTRLN-SLRVLHLEGNNLTGEIPLEF-RDVKHLSELRLND 384 + SIP +L ++N + ++HL N L L F V HL L LN Sbjct: 376 TIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQ 435 Query: 385 NSLTG 389 N + Sbjct: 436 NRFSS 440 Score = 34.7 bits (78), Expect = 0.10, Method: Compositional matrix adjust. Identities = 39/124 (31%), Positives = 53/124 (42%), Gaps = 3/124 (2%) Query: 271 ESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLM 330 E+ L L +LDL +++ P + QGL L L L + + F+ LK L Sbjct: 67 EAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALT 126 Query: 331 ILVLSNTNIQG-SIPKSLTRLNSLRVLHLEGNN--LTGEIPLEFRDVKHLSELRLNDNSL 387 L LS I+ + S +LNSL+ + N L E LE K LS L NSL Sbjct: 127 RLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSL 186 Query: 388 TGPV 391 V Sbjct: 187 YSRV 190 >3A7C-A nrPDB Length = 580 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 50/161 (31%), Positives = 71/161 (44%), Gaps = 5/161 (3%) Query: 222 SIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVL 281 SIP + A+ LDL+ N +T L +C +L + L +R+ ++ L L Sbjct: 45 SIPSGLTAAMKSLDLSFNKITYIGHGDLRACANLQVLILKSSRINTIEGDAFYSLGSLEH 104 Query: 282 LDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQG 341 LDLS N LS S L+SL+ L L GN + T + F L NL L + N Sbjct: 105 LDLSDNHLSSLSSSWFGPLSSLKYLNLMGN-PYQTLGVTSLFPNLTNLQTLRIGNVETFS 163 Query: 342 SIPK----SLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLS 378 I + LT LN L + L N + RD+ HL+ Sbjct: 164 EIRRIDFAGLTSLNELEIKALSLRNYQSQSLKSIRDIHHLT 204 Score = 30.0 bits (66), Expect = 2.4, Method: Compositional matrix adjust. Identities = 21/62 (33%), Positives = 32/62 (51%) Query: 156 RLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLS 215 R ++LQ L+L+ + D +L +L+ LDL NHL+ F S L+ L+L Sbjct: 73 RACANLQVLILKSSRINTIEGDAFYSLGSLEHLDLSDNHLSSLSSSWFGPLSSLKYLNLM 132 Query: 216 GN 217 GN Sbjct: 133 GN 134 >5LFN-A nrPDB Length = 337 Score = 45.8 bits (107), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 45/173 (26%), Positives = 81/173 (46%), Gaps = 6/173 (3%) Query: 202 SFNRFSGLRSLDLSGNRLTGSIPGFVLPALS--VLDLNQNLLTGPVPPTLTSCGSLIKID 259 +F+ + L L L N++T G + P ++ +L LN N + L + Sbjct: 96 AFDDLTELTYLYLDHNKVTELPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWLY 155 Query: 260 LSRNRVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIP 319 LS N ++ P +++ + L + N+LS ++L L ++ L L N +IP Sbjct: 156 LSENALSSLQPGALDDVENLAKFHVDRNQLSSYPSAALSKLRVVEELKLSHNP--LKSIP 213 Query: 320 ENAFKGL-KNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEF 371 +NAF+ + L L L NTN++ + + +L+ +HLE N L ++P F Sbjct: 214 DNAFQSFGRYLETLWLDNTNLEKFSDGAFLGVTTLKHVHLENNRL-NQLPSNF 265 Score = 41.6 bits (96), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 41/157 (26%), Positives = 69/157 (43%), Gaps = 3/157 (1%) Query: 254 SLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTK 313 +L+ + L ++ + L QL+ L LS+N + + L L L L N Sbjct: 54 NLVSLHLQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVLRAGAFDDLTELTYLYLDHNK- 112 Query: 314 FSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRD 373 T +P L NL IL L+N I+ + LR L+L N L+ P D Sbjct: 113 -VTELPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWLYLSENALSSLQPGALDD 171 Query: 374 VKHLSELRLNDNSLTGPVPFERDTVWRMRRKLRLYNN 410 V++L++ ++ N L+ P + R+ +L+L +N Sbjct: 172 VENLAKFHVDRNQLSS-YPSAALSKLRVVEELKLSHN 207 Score = 35.4 bits (80), Expect = 0.055, Method: Compositional matrix adjust. Identities = 39/161 (24%), Positives = 66/161 (40%), Gaps = 2/161 (1%) Query: 227 VLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLLDLSY 286 +P L L L + LI + LS N + + + L +L L L + Sbjct: 51 AMPNLVSLHLQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVLRAGAFDDLTELTYLYLDH 110 Query: 287 NRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKS 346 N+++ L L +L L L N + AF+G K+L L LS + P + Sbjct: 111 NKVTELPRGLLSPLVNLFILQLNNNK--IRELRAGAFQGAKDLRWLYLSENALSSLQPGA 168 Query: 347 LTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLNDNSL 387 L + +L H++ N L+ ++ + EL+L+ N L Sbjct: 169 LDDVENLAKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPL 209 >2XOT-A nrPDB Length = 361 Score = 45.8 bits (107), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 56/164 (34%), Positives = 74/164 (45%), Gaps = 13/164 (7%) Query: 143 LGRAPQRIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLS 202 L PQ +P++ L S L R P LTNL L L NHLN + Sbjct: 30 LPNVPQSLPSYTALLDLSHNNLS-RLRAEWTPT-----RLTNLHSLLLSHNHLNFISSEA 83 Query: 203 FNRFSGLRSLDLSGNRLTGSIPGFV---LPALSVLDLNQNLLTGPVPPTLTSCGSLIKID 259 F LR LDLS N L ++ F+ L AL VL L N + L K+ Sbjct: 84 FVPVPNLRYLDLSSNHL-HTLDEFLFSDLQALEVLLLYNNHIVVVDRNAFEDMAQLQKLY 142 Query: 260 LSRNRVTGPIPESI---NRLNQLVLLDLSYNRLSGPFPSSLQGL 300 LS+N+++ E I N+L +L+LLDLS N+L + LQ L Sbjct: 143 LSQNQISRFPVELIKDGNKLPKLMLLDLSSNKLKKLPLTDLQKL 186 >3B2D-A nrPDB Length = 603 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 73/239 (30%), Positives = 101/239 (42%), Gaps = 12/239 (5%) Query: 159 SSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGN- 217 + LQ L L G +P + L LK L L NH + +S F L L + GN Sbjct: 275 TQLQELDLTATHLKG-LPSGMKGLNLLKKLVLSVNHFDQLCQISAANFPSLTHLYIRGNV 333 Query: 218 -RLTGSIPGF-VLPALSVLDLNQNLLTGP--VPPTLTSCGSLIKIDLSRNRVTGPIPESI 273 +L + L L LDL+ N + L + L ++LS N G ++ Sbjct: 334 KKLHLGVGCLEKLGNLQTLDLSHNDIEASDCCSLQLKNLSHLQTLNLSHNEPLGLQSQAF 393 Query: 274 NRLNQLVLLDLSYNRLSGPFPSS-LQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMIL 332 QL LLDL++ RL P S Q L+ LQ L L F T ++ GL L L Sbjct: 394 KECPQLELLDLAFTRLHINAPQSPFQNLHFLQVLNLT--YCFLDTSNQHLLAGLPVLRHL 451 Query: 333 VLSNTNIQ-GSIPKS--LTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLNDNSLT 388 L + Q G+I K+ L + SL VL L L F + +S + L+ NSLT Sbjct: 452 NLKGNHFQDGTITKTNLLQTVGSLEVLILSSCGLLSIDQQAFHSLGKMSHVDLSHNSLT 510 Score = 29.3 bits (64), Expect = 4.0, Method: Compositional matrix adjust. Identities = 45/148 (30%), Positives = 66/148 (44%), Gaps = 6/148 (4%) Query: 159 SSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLS-FNRFSGLRSLDLSGN 217 S LQTL L N LG L++LDL L+ + P S F L+ L+L+ Sbjct: 373 SHLQTLNLSHNEPLGLQSQAFKECPQLELLDLAFTRLHINAPQSPFQNLHFLQVLNLTYC 432 Query: 218 RLTGSIPGFV--LPALSVLDLNQNLLT-GPVPPT--LTSCGSLIKIDLSRNRVTGPIPES 272 L S + LP L L+L N G + T L + GSL + LS + ++ Sbjct: 433 FLDTSNQHLLAGLPVLRHLNLKGNHFQDGTITKTNLLQTVGSLEVLILSSCGLLSIDQQA 492 Query: 273 INRLNQLVLLDLSYNRLSGPFPSSLQGL 300 + L ++ +DLS+N L+ SL L Sbjct: 493 FHSLGKMSHVDLSHNSLTCDSIDSLSHL 520 >3A79-B nrPDB Length = 562 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 40/134 (29%), Positives = 72/134 (53%), Gaps = 12/134 (8%) Query: 161 LQTLVLRENGFLGPIPDEL--GNLTNLKVLDLHKNHLNGSIPLSFNRFSG----LRSLDL 214 LQTL+L+ NG L N+++L+ LD+ N LN +++R + L+L Sbjct: 379 LQTLILQRNGLKNFFKVALMTKNMSSLETLDVSLNSLNSH---AYDRTCAWAESILVLNL 435 Query: 215 SGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESI- 273 S N LTGS+ + P + VLDL+ N + +P +T +L +++++ N++ +P+ + Sbjct: 436 SSNMLTGSVFRCLPPKVKVLDLHNNRIMS-IPKDVTHLQALQELNVASNQLKS-VPDGVF 493 Query: 274 NRLNQLVLLDLSYN 287 +RL L + L N Sbjct: 494 DRLTSLQYIWLHDN 507 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 46/162 (28%), Positives = 68/162 (41%), Gaps = 16/162 (9%) Query: 159 SSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNG--SIPLSFNRFSGLRSLDLSG 216 SS L +N F + L L+ L L +N L + L S L +LD+S Sbjct: 353 SSFTFLNFTQNVFTDSVFQGCSTLKRLQTLILQRNGLKNFFKVALMTKNMSSLETLDVSL 412 Query: 217 NRLTGSIPGFVLP---ALSVLDLNQNLLTGPV----PPTLTSCGSLIKIDLSRNRVTGPI 269 N L ++ VL+L+ N+LTG V PP + +DL NR+ I Sbjct: 413 NSLNSHAYDRTCAWAESILVLNLSSNMLTGSVFRCLPPKVKV------LDLHNNRIMS-I 465 Query: 270 PESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGN 311 P+ + L L L+++ N+L L SLQ + L N Sbjct: 466 PKDVTHLQALQELNVASNQLKSVPDGVFDRLTSLQYIWLHDN 507 >5YQ5-A nrPDB Length = 430 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 45/149 (30%), Positives = 69/149 (46%), Gaps = 8/149 (5%) Query: 157 LGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLS--FNRFSGLRSLDL 214 L SL+ L+L N + + L NL +LDL N+L+ S+ F + L L+L Sbjct: 158 LPKSLERLLLGYNEISKLQTNAMDGLVNLTMLDLCYNYLHDSLLKDKIFAKMEKLMQLNL 217 Query: 215 SGNRLTGSIPGFVLP-ALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESI 273 NRL PG LP +L L L N ++ L + +S N++ IP +I Sbjct: 218 CSNRLESMPPG--LPSSLMYLSLENNSISSIPEKYFDKLPKLHTLRMSHNKLQD-IPYNI 274 Query: 274 NRLNQLVLLDLSYNRLSGPF--PSSLQGL 300 L +V L + +N+L F P +L+ L Sbjct: 275 FNLPNIVELSVGHNKLKQAFYIPRNLEHL 303 Score = 36.6 bits (83), Expect = 0.023, Method: Compositional matrix adjust. Identities = 41/144 (28%), Positives = 74/144 (51%), Gaps = 15/144 (10%) Query: 254 SLIKIDLSRNRVTG---PIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKG 310 +L+++ L N + P+P+S+ RL L YN +S +++ GL +L L L Sbjct: 140 NLLQLHLEHNNLEEFPFPLPKSLERL------LLGYNEISKLQTNAMDGLVNLTMLDLCY 193 Query: 311 NTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLE 370 N + + + F ++ LM L L + ++ S+P L +SL L LE N+++ IP + Sbjct: 194 NYLHDSLLKDKIFAKMEKLMQLNLCSNRLE-SMPPGLP--SSLMYLSLENNSISS-IPEK 249 Query: 371 FRD-VKHLSELRLNDNSLTGPVPF 393 + D + L LR++ N L +P+ Sbjct: 250 YFDKLPKLHTLRMSHNKLQD-IPY 272 >2V9T-B nrPDB Length = 220 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 49/194 (25%), Positives = 89/194 (45%), Gaps = 4/194 (2%) Query: 212 LDLSGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPE 271 +D G LT IP + ++ + L QN + P + L +IDLS N+++ P+ Sbjct: 16 VDCRGKGLT-EIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPD 74 Query: 272 SINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMI 331 + L L L L N+++ S +GL SLQ L+L N + +AF+ L NL + Sbjct: 75 AFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRV--DAFQDLHNLNL 132 Query: 332 LVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEF-RDVKHLSELRLNDNSLTGP 390 L L + +Q + + L +++ +HL N + L++ D H + + + T P Sbjct: 133 LSLYDNKLQTIAKGTFSPLRAIQTMHLAQNPFICDCHLKWLADYLHTNPIETSGARCTSP 192 Query: 391 VPFERDTVWRMRRK 404 + +++ K Sbjct: 193 RRLANKRIGQIKSK 206 Score = 28.1 bits (61), Expect = 8.1, Method: Compositional matrix adjust. Identities = 21/79 (26%), Positives = 33/79 (41%), Gaps = 3/79 (3%) Query: 142 CLGRAPQRIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPL 201 C G+ IP L ++ + L +N P L+ +DL N ++ P Sbjct: 18 CRGKGLTEIPT---NLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPD 74 Query: 202 SFNRFSGLRSLDLSGNRLT 220 +F L SL L GN++T Sbjct: 75 AFQGLRSLNSLVLYGNKIT 93 >4PUF-A nrPDB Length = 637 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 46/145 (31%), Positives = 75/145 (51%), Gaps = 30/145 (20%) Query: 149 RIPAFLGRLGSSLQTLVLRENGFL---GPIPDELGNLT----NLKVLDLH----KNHLN- 196 RI RL S+LQ+L L N +P+EL L+ +++ L H HLN Sbjct: 124 RITELPERLPSALQSLDLFHNKISCLPENLPEELRYLSVYDNSIRTLPAHLPSEITHLNV 183 Query: 197 -----GSIPLSFNRFSGLRSLDLSGNRLTGSIPGFVLPALSVLDLNQNLLT---GPVPPT 248 ++P + GL++L+ N LT S+P + P L VLD+++N +T +PPT Sbjct: 184 QSNSLTALPETLP--PGLKTLEAGENALT-SLPASLPPELQVLDVSKNQITVLPETLPPT 240 Query: 249 LTSCGSLIKIDLSRNRVTGPIPESI 273 +T+ +D+SRN +T +PE++ Sbjct: 241 ITT------LDVSRNALTN-LPENL 258 Score = 34.3 bits (77), Expect = 0.13, Method: Compositional matrix adjust. Identities = 66/235 (28%), Positives = 100/235 (42%), Gaps = 52/235 (22%) Query: 131 LKHLKALFFYRCLGRAPQRIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDL 190 LK+ K + LG IPA++ + TL+L +N L +P+ L N+K L Sbjct: 48 LKNNKTELRLKILGLTT--IPAYIP---EQITTLIL-DNNELKSLPENLQG--NIKTLYA 99 Query: 191 HKNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLT 250 + N L SIP + ++ ++LS NR+T +P + AL LDL N + Sbjct: 100 NSNQLT-SIPATLP--DTIQEMELSINRIT-ELPERLPSALQSLDLFHNKI--------- 146 Query: 251 SCGSLIKIDLSRNRVTGPIPESI-NRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLK 309 SC +PE++ L L + D S L PS + LN ++ Sbjct: 147 SC----------------LPENLPEELRYLSVYDNSIRTLPAHLPSEITHLN------VQ 184 Query: 310 GNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLT 364 N+ T +PE GLK L + N S+P SL L+VL + N +T Sbjct: 185 SNSL--TALPETLPPGLKTLE----AGENALTSLPASLP--PELQVLDVSKNQIT 231 >5MX0-A nrPDB Length = 362 Score = 39.7 bits (91), Expect = 0.003, Method: Compositional matrix adjust. Identities = 53/198 (26%), Positives = 81/198 (40%), Gaps = 34/198 (17%) Query: 217 NRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTG-----PIPE 271 NR +P FV + + N +T + L+ I L N++T + Sbjct: 80 NRNLKYLP-FVPSRMKYVYFQNNQITSIQEGVFDNATGLLWIALHGNQITSDKVGRKVFS 138 Query: 272 SINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMI 331 + L +L L + R+ GP P SL+ L+ L N + +P NA +GL+NL Sbjct: 139 KLRHLERLYLDHNNLTRMPGPLPRSLRELH------LDHNQ--ISRVPNNALEGLENLTA 190 Query: 332 LVLSNTNIQ--GSIPKSLTRL------------------NSLRVLHLEGNNLTGEIPLEF 371 L L + IQ GS + L L ++L L++E NN+ F Sbjct: 191 LYLQHNEIQEVGSSMRGLRSLILLDLSYNHLRKVPDGLPSALEQLYMEHNNVYTVPDSYF 250 Query: 372 RDVKHLSELRLNDNSLTG 389 R L +RL+ NSLT Sbjct: 251 RGAPKLLYVRLSHNSLTN 268 >4R08-A nrPDB Length = 811 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 62/213 (29%), Positives = 80/213 (37%), Gaps = 30/213 (14%) Query: 156 RLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKN---HLNGSIP------------ 200 +L SSL+ L L ++ L NL +LDL N N P Sbjct: 197 KLPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINI 256 Query: 201 --LSFNRFSGLRSLDLSGNRLTGSIPGFV--LPALSVLDLNQNLLTGPVP--PTLTSCGS 254 +F + LR L+LS L + +P L VLDL N L G + LT Sbjct: 257 DRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPR 316 Query: 255 LIKIDLSRNRVTGPIPESIN-RLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGN-- 311 L +DLS N + G P+ IN N LL L L G L+ + Q LM N Sbjct: 317 LEILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELRE-DDFQPLMQLPNLS 375 Query: 312 -----TKFSTTIPENAFKGLKNLMILVLSNTNI 339 F I F+ NL I+ LS I Sbjct: 376 TINLGINFIKQIDFKLFQNFSNLEIIYLSENRI 408 Score = 32.0 bits (71), Expect = 0.64, Method: Compositional matrix adjust. Identities = 70/259 (27%), Positives = 98/259 (37%), Gaps = 50/259 (19%) Query: 178 ELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPGFV--------LP 229 E + ++K LDL N L+ + S L LDLS N I G Sbjct: 503 EFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFT 562 Query: 230 ALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINR-------LNQLVLL 282 L VL+L+ N + SL+++ S NR+ + NR L L L Sbjct: 563 NLKVLNLSHNNIYTLTDKYNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLTRL 622 Query: 283 DLSYNRLSG-------PFPSSLQGLN------------------SLQALMLKGNTKFSTT 317 DLS NRL P+SL L+ L+ L L+GN T Sbjct: 623 DLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLT 682 Query: 318 IPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLT--GEIPLEFRDVK 375 + F +L L+LS+ I L+ ++SL+ L L N L + LE + Sbjct: 683 DSLSDFTS--SLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTT 740 Query: 376 HLSELRLNDNSLTGPVPFE 394 LS L L+ N PFE Sbjct: 741 KLSMLELHGN------PFE 753 Score = 30.8 bits (68), Expect = 1.3, Method: Compositional matrix adjust. Identities = 59/198 (29%), Positives = 89/198 (44%), Gaps = 25/198 (12%) Query: 210 RSLDLSGNRLTGSIPGFV--LPALSVLDLNQNLLTGPVPPTLTSCGSLIK-IDLSRNRVT 266 ++LDLS N + P LP ++ L+L+ N + T S +K +DL+ NR+ Sbjct: 462 KALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLD 521 Query: 267 GPIPESINRLNQLVLLDLSYN----RLSG--PFPSSLQGLNSLQALMLKGNTKFSTT--- 317 ++ L+ L +LDLSYN R++G +Q +L+ L L N ++ T Sbjct: 522 FDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKY 581 Query: 318 ------IPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLE- 370 + E F G L IL + N SI K L L L + N IP E Sbjct: 582 NLESKSLVELVFSG-NRLDILWNDDDNRYISIFKGLKNLTRLDL----SLNRLKHIPNEA 636 Query: 371 FRDV-KHLSELRLNDNSL 387 F ++ L+EL +NDN L Sbjct: 637 FLNLPASLTELHINDNML 654 Score = 30.4 bits (67), Expect = 1.8, Method: Compositional matrix adjust. Identities = 50/163 (30%), Positives = 63/163 (38%), Gaps = 49/163 (30%) Query: 245 VPPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNR---LSGPFPS------ 295 VPP L S SL K+ LS ++ E L L LLDLS N + PFP Sbjct: 194 VPPKLPS--SLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGG 251 Query: 296 --------SLQGLNSLQALML------KGNTKFSTTIPE--------NAFKG-------- 325 + Q L L+ L L K N + +P N G Sbjct: 252 ASINIDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFL 311 Query: 326 --LKNLMILVLSNTNIQGSIP------KSLTRLNSLRVLHLEG 360 L L IL LS I+GS P ++ ++L SLR LHL G Sbjct: 312 TMLPRLEILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRG 354 >5GY2-A nrPDB Length = 455 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 37/141 (26%), Positives = 62/141 (43%), Gaps = 4/141 (2%) Query: 207 SGLRSLDLSGNRLTGSIPGFV--LPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNR 264 SG+++ DLS +++ + L L L QN + L+K++LS+N Sbjct: 275 SGVKTCDLSKSKIFALLKSVFSHFTDLEQLTLAQNEINKIDDNAFWGLTHLLKLNLSQNF 334 Query: 265 VTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFK 324 + L++L +LDLSYN + S GL +L+ L L N ++P+ F Sbjct: 335 LGSIDSRMFENLDKLEVLDLSYNHIRALGDQSFLGLPNLKELALDTNQL--KSVPDGIFD 392 Query: 325 GLKNLMILVLSNTNIQGSIPK 345 L +L + L S P+ Sbjct: 393 RLTSLQKIWLHTNPWDCSCPR 413 Score = 35.4 bits (80), Expect = 0.051, Method: Compositional matrix adjust. Identities = 36/116 (31%), Positives = 54/116 (46%), Gaps = 5/116 (4%) Query: 276 LNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLS 335 L+ L++L L YN+ + GL +L+ L L + N FK L +L +LVL Sbjct: 78 LSSLIILKLDYNQFLQLETGAFNGLANLEVLTLTQCNLDGAVLSGNFFKPLTSLEMLVLR 137 Query: 336 NTNIQGSIPKS-LTRLNSLRVLHLEGNNLTG---EIPLEFRDVKHLSELRLNDNSL 387 + NI+ P S + VL L N + E L F+ KH + LRL+ +L Sbjct: 138 DNNIKKIQPASFFLNMRRFHVLDLTFNKVKSICEEDLLNFQG-KHFTLLRLSSITL 192 Score = 34.3 bits (77), Expect = 0.12, Method: Compositional matrix adjust. Identities = 41/148 (27%), Positives = 62/148 (41%), Gaps = 6/148 (4%) Query: 247 PTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQAL 306 P + C + + NR +PE +N +DLS N ++ +S L LQ L Sbjct: 3 PGTSECSVIGYNAICINRGLHQVPELPAHVN---YVDLSLNSIAELNETSFSRLQDLQFL 59 Query: 307 MLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGE 366 ++ T I N F+GL +L+IL L + L +L VL L NL G Sbjct: 60 KVEQQTP-GLVIRNNTFRGLSSLIILKLDYNQFLQLETGAFNGLANLEVLTLTQCNLDGA 118 Query: 367 IPLE--FRDVKHLSELRLNDNSLTGPVP 392 + F+ + L L L DN++ P Sbjct: 119 VLSGNFFKPLTSLEMLVLRDNNIKKIQP 146 Score = 30.0 bits (66), Expect = 2.4, Method: Compositional matrix adjust. Identities = 34/109 (31%), Positives = 47/109 (43%), Gaps = 10/109 (9%) Query: 115 PTCDPQRSYVSESLTRLKHLKALFFYRC----LGRAPQRIPAFLGRLG-----SSLQTLV 165 P +YV SL + L F R + Q+ P + R SSL L Sbjct: 26 PELPAHVNYVDLSLNSIAELNETSFSRLQDLQFLKVEQQTPGLVIRNNTFRGLSSLIILK 85 Query: 166 LRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDL 214 L N FL L NL+VL L + +L+G++ LS N F L SL++ Sbjct: 86 LDYNQFLQLETGAFNGLANLEVLTLTQCNLDGAV-LSGNFFKPLTSLEM 133 >3RG1-A nrPDB Length = 612 Score = 38.5 bits (88), Expect = 0.006, Method: Compositional matrix adjust. Identities = 70/271 (25%), Positives = 110/271 (40%), Gaps = 36/271 (13%) Query: 152 AFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRS 211 F G S++++ L+++ F T ++ LDL HLNG +P + L+ Sbjct: 246 TFEGLCDMSVESINLQKHRFSDLSSSTFRCFTRVQELDLTAAHLNG-LPSGIEGMNSLKK 304 Query: 212 LDLSGNRL-------TGSIPGF--------------------VLPALSVLDLNQNLLTGP 244 L L+ N S P L L LDL+ + + Sbjct: 305 LVLNANSFDQLCQINAASFPSLRDLYIKGNMRKLDLGTRCLEKLENLQKLDLSHSDIEAS 364 Query: 245 --VPPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSGPFPSS-LQGLN 301 L + L ++LS N G ++ QL LLD+++ L P S Q L+ Sbjct: 365 DCCNLQLKNLRHLQYLNLSYNEPLGLEDQAFKECPQLELLDVAFTHLHVKAPHSPFQNLH 424 Query: 302 SLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQ-GSIPKS--LTRLNSLRVLHL 358 L+ L L T ++ GL++L L L + Q GSI K+ L + SL +L L Sbjct: 425 LLRVLNLSH--CLLDTSNQHLLAGLQDLRHLNLQGNSFQDGSISKTNLLQMVGSLEILIL 482 Query: 359 EGNNLTGEIPLEFRDVKHLSELRLNDNSLTG 389 NL F +++++ L L+ NSLTG Sbjct: 483 SSCNLLSIDQQAFHGLRNVNHLDLSHNSLTG 513 Score = 33.5 bits (75), Expect = 0.23, Method: Compositional matrix adjust. Identities = 67/268 (25%), Positives = 105/268 (39%), Gaps = 50/268 (18%) Query: 140 YRCLGRAPQR--IPAFLGRLGS------SLQTLVLRENGFLGPIPDELGNLTNLKVLDLH 191 +RC R + A L L S SL+ LVL N F D+L + L Sbjct: 273 FRCFTRVQELDLTAAHLNGLPSGIEGMNSLKKLVLNANSF-----DQLCQINAASFPSLR 327 Query: 192 KNHLNGSI------PLSFNRFSGLRSLDLSGNRLTGS----IPGFVLPALSVLDLNQNLL 241 ++ G++ + L+ LDLS + + S + L L L+L+ N Sbjct: 328 DLYIKGNMRKLDLGTRCLEKLENLQKLDLSHSDIEASDCCNLQLKNLRHLQYLNLSYNEP 387 Query: 242 TGPVPPTLTSCGSLIKIDLSRNRVTGPIPES-INRLNQLVLLDLSYNRLSGPFPSSLQGL 300 G C L +D++ + P S L+ L +L+LS+ L L GL Sbjct: 388 LGLEDQAFKECPQLELLDVAFTHLHVKAPHSPFQNLHLLRVLNLSHCLLDTSNQHLLAGL 447 Query: 301 NSLQALMLKGNT----KFSTT---------------------IPENAFKGLKNLMILVLS 335 L+ L L+GN+ S T I + AF GL+N+ L LS Sbjct: 448 QDLRHLNLQGNSFQDGSISKTNLLQMVGSLEILILSSCNLLSIDQQAFHGLRNVNHLDLS 507 Query: 336 NTNIQGSIPKSLTRLNSLRVLHLEGNNL 363 + ++ G +L+ L L L++ NN+ Sbjct: 508 HNSLTGDSMDALSHLKGL-YLNMASNNI 534 >5Y31-B nrPDB Length = 544 Score = 38.1 bits (87), Expect = 0.009, Method: Compositional matrix adjust. Identities = 25/74 (33%), Positives = 45/74 (60%), Gaps = 4/74 (5%) Query: 299 GLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTR-LNSLRVLH 357 GL L+ L ++ N +I + F+GLK+L+ L L+N N+Q ++PK + + L+SL + Sbjct: 93 GLPHLEYLFIENNN--IKSISRHTFRGLKSLIHLSLANNNLQ-TLPKDIFKGLDSLTNVD 149 Query: 358 LEGNNLTGEIPLEF 371 L GN+ + L++ Sbjct: 150 LRGNSFNCDCKLKW 163 >6J5T-G nrPDB Length = 852 Score = 36.2 bits (82), Expect = 0.033, Method: Compositional matrix adjust. Identities = 33/121 (27%), Positives = 48/121 (39%), Gaps = 5/121 (4%) Query: 239 NLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPE---SINRLNQLVLLDLSYNRLSGPFPS 295 N L + T C L +D+S++ P+ E I L L L LS FP Sbjct: 545 NKLNSDLAKKFTDCKYLRVLDISKSIFDAPLSEILDEIASLQHLACLSLSNTHPLIQFPR 604 Query: 296 SLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRV 355 S++ L++LQ L P K L++L ++N PK + L L V Sbjct: 605 SMEDLHNLQILDASYCQNLKQLQP--CIVLFKKLLVLDMTNCGSLECFPKGIGSLVKLEV 662 Query: 356 L 356 L Sbjct: 663 L 663 >3T6Q-A nrPDB Length = 606 Score = 36.2 bits (82), Expect = 0.036, Method: Compositional matrix adjust. Identities = 42/136 (30%), Positives = 66/136 (48%), Gaps = 6/136 (4%) Query: 181 NLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRL-TGSIPGF----VLPALSVLD 235 NL LKVL+L + L+ S F+ L+ L+L GN G+I L L +L Sbjct: 423 NLHLLKVLNLSHSLLDISSEQLFDGLPALQHLNLQGNHFPKGNIQKTNSLQTLGRLEILV 482 Query: 236 LNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSGPFPS 295 L+ L+ TS + +DLS NR+T E+++ L + L+L+ N +S PS Sbjct: 483 LSFCDLSSIDQHAFTSLKMMNHVDLSHNRLTSSSIEALSHLKG-IYLNLASNHISIILPS 541 Query: 296 SLQGLNSLQALMLKGN 311 L L+ + + L+ N Sbjct: 542 LLPILSQQRTINLRQN 557 Score = 32.7 bits (73), Expect = 0.39, Method: Compositional matrix adjust. Identities = 63/236 (26%), Positives = 102/236 (43%), Gaps = 18/236 (7%) Query: 136 ALFFYRCLGRAPQRIPAFLGRLGSSLQTLVLRENGFLGPIPDE------LGNLTNLKV-- 187 A+F G + F G S++Q+L L G + DE L + V Sbjct: 202 AVFQSLNFGGTQNLLVIFKGLKNSTIQSLWL---GTFEDMDDEDISPAVFEGLCEMSVES 258 Query: 188 LDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPGFV-LPALSVLDLNQNLLTGPVP 246 ++L K++ +F+ FSGL+ LDL+ L+ G V L L L L+ N Sbjct: 259 INLQKHYFFNISSNTFHCFSGLQELDLTATHLSELPSGLVGLSTLKKLVLSANKFENLCQ 318 Query: 247 PTLTSCGSLIKIDLSRNRVTGPIPE-SINRLNQLVLLDLSYNRLSGPFPSSLQ--GLNSL 303 + ++ SL + + N + + L L LDLS++ + +LQ L+ L Sbjct: 319 ISASNFPSLTHLSIKGNTKRLELGTGCLENLENLRELDLSHDDIETSDCCNLQLRNLSHL 378 Query: 304 QALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKS-LTRLNSLRVLHL 358 Q+L L N S + AFK L +L L+ T ++ +S L+ L+VL+L Sbjct: 379 QSLNLSYNEPLS--LKTEAFKECPQLELLDLAFTRLKVKDAQSPFQNLHLLKVLNL 432 Score = 28.5 bits (62), Expect = 6.4, Method: Compositional matrix adjust. Identities = 35/118 (29%), Positives = 56/118 (47%), Gaps = 5/118 (4%) Query: 255 LIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKF 314 L ++DL+ ++ +P + L+ L L LS N+ S SL L +KGNTK Sbjct: 280 LQELDLTATHLS-ELPSGLVGLSTLKKLVLSANKFENLCQISASNFPSLTHLSIKGNTK- 337 Query: 315 STTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFR 372 + + L+NL L LS+ +I+ S +L N + HL+ NL+ PL + Sbjct: 338 RLELGTGCLENLENLRELDLSHDDIETSDCCNLQLRN---LSHLQSLNLSYNEPLSLK 392 >3V44-A nrPDB Length = 407 Score = 35.8 bits (81), Expect = 0.039, Method: Compositional matrix adjust. Identities = 36/116 (31%), Positives = 54/116 (46%), Gaps = 5/116 (4%) Query: 276 LNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLS 335 L+ L++L L YN+ + GL +L+ L L + N FK L +L +LVL Sbjct: 78 LSSLIILKLDYNQFLQLETGAFNGLANLEVLTLTQCNLDGAVLSGNFFKPLTSLEMLVLR 137 Query: 336 NTNIQGSIPKS-LTRLNSLRVLHLEGNNLTG---EIPLEFRDVKHLSELRLNDNSL 387 + NI+ P S + VL L N + E L F+ KH + LRL+ +L Sbjct: 138 DNNIKKIQPASFFLNMRRFHVLDLTFNKVKSICEEDLLNFQG-KHFTLLRLSSITL 192 Score = 34.7 bits (78), Expect = 0.098, Method: Compositional matrix adjust. Identities = 41/148 (27%), Positives = 62/148 (41%), Gaps = 6/148 (4%) Query: 247 PTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQAL 306 P + C + + NR +PE +N +DLS N ++ +S L LQ L Sbjct: 3 PGTSECSVIGYNAICINRGLHQVPELPAHVN---YVDLSLNSIAELNETSFSRLQDLQFL 59 Query: 307 MLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGE 366 ++ T I N F+GL +L+IL L + L +L VL L NL G Sbjct: 60 KVEQQTP-GLVIRNNTFRGLSSLIILKLDYNQFLQLETGAFNGLANLEVLTLTQCNLDGA 118 Query: 367 IPLE--FRDVKHLSELRLNDNSLTGPVP 392 + F+ + L L L DN++ P Sbjct: 119 VLSGNFFKPLTSLEMLVLRDNNIKKIQP 146 Score = 33.5 bits (75), Expect = 0.23, Method: Compositional matrix adjust. Identities = 91/344 (26%), Positives = 133/344 (38%), Gaps = 52/344 (15%) Query: 115 PTCDPQRSYVSESLTRLKHLKALFFYRC----LGRAPQRIPAFLGRLG-----SSLQTLV 165 P +YV SL + L F R + Q+ P + R SSL L Sbjct: 26 PELPAHVNYVDLSLNSIAELNETSFSRLQDLQFLKVEQQTPGLVIRNNTFRGLSSLIILK 85 Query: 166 LRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLD---LSGNRLTGS 222 L N FL L NL+VL L + +L+G++ LS N F L SL+ L N + Sbjct: 86 LDYNQFLQLETGAFNGLANLEVLTLTQCNLDGAV-LSGNFFKPLTSLEMLVLRDNNIKKI 144 Query: 223 IPG-FVLPA--LSVLDLNQNLLTGPVPP----------TLTSCGSLIKIDLSRNRVTGPI 269 P F L VLDL N + TL S+ D++ + Sbjct: 145 QPASFFLNMRRFHVLDLTFNKVKSICEEDLLNFQGKHFTLLRLSSITLQDMNEYWLGWEK 204 Query: 270 PESINRLNQLVLLDLSYN----RLSGPFPSSLQGLNSLQALMLK---------GNTKFST 316 + + + LDLS N ++ F ++ G +Q+L+L G+T F Sbjct: 205 CGNPFKNTSITTLDLSGNGFKESMAKRFFDAIAG-TKIQSLILSNSYNMGSSFGHTNFKD 263 Query: 317 TIPEN-AFKGLK--NLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRD 373 P+N FKGL+ + LS + I + + L L L N + F Sbjct: 264 --PDNFTFKGLEASGVKTCDLSKSKIFALLKSVFSHFTDLEQLTLAQNEINKIDDNAFWG 321 Query: 374 VKHLSELRLNDNSLTGPVP---FERDTVWRMRRKLRLYNNAGLC 414 + HL EL L+ N L VP F+R T +K+ L+ N C Sbjct: 322 LTHLKELALDTNQLKS-VPDGIFDRLT---SLQKIWLHTNPWDC 361 >2FT3-A nrPDB Length = 332 Score = 35.4 bits (80), Expect = 0.062, Method: Compositional matrix adjust. Identities = 25/68 (36%), Positives = 38/68 (55%), Gaps = 3/68 (4%) Query: 320 ENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSE 379 ++ FKGL++L LVL N I K+ + L L+ L++ N+L EIP L E Sbjct: 71 KDDFKGLQHLYALVLVNNKISKIHEKAFSPLRKLQKLYISKNHLV-EIPPNLPS--SLVE 127 Query: 380 LRLNDNSL 387 LR++DN + Sbjct: 128 LRIHDNRI 135 Score = 32.7 bits (73), Expect = 0.34, Method: Compositional matrix adjust. Identities = 49/180 (27%), Positives = 73/180 (40%), Gaps = 21/180 (11%) Query: 201 LSFNRFSGLRSLDLSGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDL 260 L N S LR D G L L L L N ++ + L K+ + Sbjct: 61 LQNNDISELRKDDFKG-----------LQHLYALVLVNNKISKIHEKAFSPLRKLQKLYI 109 Query: 261 SRNRVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPE 320 S+N + P N + LV L + NR+ GL ++ + + GN ++ Sbjct: 110 SKNHLVEIPP---NLPSSLVELRIHDNRIRKVPKGVFSGLRNMNCIEMGGNPLENSGFEP 166 Query: 321 NAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSEL 380 AF GLK L L +S + G IPK L +L LHL+ N + +E D+ S+L Sbjct: 167 GAFDGLK-LNYLRISEAKLTG-IPKDLPE--TLNELHLDHNKIQA---IELEDLLRYSKL 219 Score = 30.8 bits (68), Expect = 1.5, Method: Compositional matrix adjust. Identities = 32/114 (28%), Positives = 51/114 (44%), Gaps = 12/114 (10%) Query: 245 VPPTLTS-----CGSLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQG 299 +PPT ++ C +++ + +P+ I+ LLDL N +S +G Sbjct: 19 LPPTYSAMCPFGCHCHLRVVQCSDLGLKAVPKEISP--DTTLLDLQNNDISELRKDDFKG 76 Query: 300 LNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTN---IQGSIPKSLTRL 350 L L AL+L N + I E AF L+ L L +S + I ++P SL L Sbjct: 77 LQHLYALVLVNNK--ISKIHEKAFSPLRKLQKLYISKNHLVEIPPNLPSSLVEL 128 Score = 30.4 bits (67), Expect = 1.6, Method: Compositional matrix adjust. Identities = 56/221 (25%), Positives = 100/221 (45%), Gaps = 24/221 (10%) Query: 177 DELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPGFVLPALSVLDL 236 D+ L +L L L N ++ +F+ L+ L +S N L IP + +L L + Sbjct: 72 DDFKGLQHLYALVLVNNKISKIHEKAFSPLRKLQKLYISKNHLV-EIPPNLPSSLVELRI 130 Query: 237 NQNLLTGPVPPTLTSCGSLIKIDLSRNRV--TGPIPESINRLNQLVLLDLSYNRLSG--- 291 + N + + ++ I++ N + +G P + + L +L L +S +L+G Sbjct: 131 HDNRIRKVPKGVFSGLRNMNCIEMGGNPLENSGFEPGAFDGL-KLNYLRISEAKLTGIPK 189 Query: 292 PFPSSLQGL----NSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSL 347 P +L L N +QA+ L+ ++S L L L + I+ SL Sbjct: 190 DLPETLNELHLDHNKIQAIELEDLLRYSK------------LYRLGLGHNQIRMIENGSL 237 Query: 348 TRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLNDNSLT 388 + L +LR LHL+ N L+ +P D+K L + L+ N++T Sbjct: 238 SFLPTLRELHLDNNKLS-RVPAGLPDLKLLQVVYLHTNNIT 277 >3G06-A nrPDB Length = 622 Score = 35.0 bits (79), Expect = 0.077, Method: Compositional matrix adjust. Identities = 60/183 (32%), Positives = 85/183 (46%), Gaps = 23/183 (12%) Query: 112 TAFPTCDPQRSYVSESLTRLKHLKALFFYRCLGRAPQRIPAFLGRLGSSLQTLVLRENGF 171 T+ P P +S S +L L AL C A L L S LQ L + +N Sbjct: 134 TSLPVLPPGLQELSVSDNQLASLPALPSELCKLWAYNNQLTSLPMLPSGLQELSVSDNQL 193 Query: 172 --LGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPGFVLP 229 L +P EL L + N L L SGL+ L +SGNRLT S+P VLP Sbjct: 194 ASLPTLPSELYKLWA------YNNRLTSLPALP----SGLKELIVSGNRLT-SLP--VLP 240 Query: 230 A-LSVLDLNQNLLTG-PVPPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYN 287 + L L ++ N LT P+ P+ L+ + + RN++T +PES+ L+ ++L N Sbjct: 241 SELKELMVSGNRLTSLPMLPS-----GLLSLSVYRNQLTR-LPESLIHLSSETTVNLEGN 294 Query: 288 RLS 290 LS Sbjct: 295 PLS 297 >2Z7X-B nrPDB Length = 520 Score = 33.9 bits (76), Expect = 0.15, Method: Compositional matrix adjust. Identities = 46/175 (26%), Positives = 71/175 (40%), Gaps = 24/175 (13%) Query: 146 APQRIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLN--GSIPLSF 203 P +I FL L N + + G+LT L+ L L N L I Sbjct: 319 CPSKISPFLH--------LDFSNNLLTDTVFENCGHLTELETLILQMNQLKELSKIAEMT 370 Query: 204 NRFSGLRSLDLSGNRLT-GSIPGFVLPALSVLDLNQ--NLLTGPV----PPTLTSCGSLI 256 + L+ LD+S N ++ G S+L LN N+LT + PP + Sbjct: 371 TQMKSLQQLDISQNSVSYDEKKGDCSWTKSLLSLNMSSNILTDTIFRCLPPRIKV----- 425 Query: 257 KIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGN 311 +DL N++ IP+ + +L L L+++ N+L L SLQ + L N Sbjct: 426 -LDLHSNKIKS-IPKQVVKLEALQELNVASNQLKSVPDGIFDRLTSLQKIWLHTN 478 Score = 31.6 bits (70), Expect = 0.85, Method: Compositional matrix adjust. Identities = 46/161 (28%), Positives = 69/161 (42%), Gaps = 10/161 (6%) Query: 164 LVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTG-S 222 LV R L +P +L T +L++ +N+++ S LR L +S NR+ Sbjct: 4 LVDRSKNGLIHVPKDLSQKTT--ILNISQNYISELWTSDILSLSKLRILIISHNRIQYLD 61 Query: 223 IPGFVL-PALSVLDLNQN-LLTGPVPPTLTSCGSLIKIDLSRNRVTG-PIPESINRLNQL 279 I F L LDL+ N L+ PT+ +L +DLS N PI + ++QL Sbjct: 62 ISVFKFNQELEYLDLSHNKLVKISCHPTV----NLKHLDLSFNAFDALPICKEFGNMSQL 117 Query: 280 VLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPE 320 L LS L + LN + L++ G T PE Sbjct: 118 KFLGLSTTHLEKSSVLPIAHLNISKVLLVLGETYGEKEDPE 158 >6HKW-A nrPDB Length = 363 Score = 33.5 bits (75), Expect = 0.24, Method: Compositional matrix adjust. Identities = 28/79 (35%), Positives = 43/79 (54%), Gaps = 6/79 (7%) Query: 212 LDLSGNRLTGSIPGF-VLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIP 270 +DL+ R+ G I GF VL + L L QNL+ L SL ++DL N++ Sbjct: 84 VDLNHYRI-GKIEGFEVLKKVKTLCLRQNLI--KCIENLEELQSLRELDLYDNQIKKI-- 138 Query: 271 ESINRLNQLVLLDLSYNRL 289 E++ L +L +LD+S+N L Sbjct: 139 ENLEALTELEILDISFNLL 157 Score = 30.4 bits (67), Expect = 1.6, Method: Compositional matrix adjust. Identities = 36/135 (26%), Positives = 63/135 (46%), Gaps = 8/135 (5%) Query: 177 DELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPGFVLPALSVLDL 236 + L NL L++L+L N + + + + L SL L N++T L L+VL + Sbjct: 183 ENLSNLHQLQMLELGSNRIRA--IENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSM 240 Query: 237 NQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSGPFPSS 296 N LT L + +L ++ LS N + + E + N+L +LD++ NR+ + Sbjct: 241 QSNRLTKI--EGLQNLVNLRELYLSHNGI--EVIEGLENNNKLTMLDIASNRIKK--IEN 294 Query: 297 LQGLNSLQALMLKGN 311 + L LQ + N Sbjct: 295 ISHLTELQEFWMNDN 309 >4QDH-A nrPDB Length = 438 Score = 32.0 bits (71), Expect = 0.69, Method: Compositional matrix adjust. Identities = 45/164 (27%), Positives = 66/164 (40%), Gaps = 30/164 (18%) Query: 222 SIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVL 281 S+P + + + L+L N L L K+ LSRN + PE L++L Sbjct: 28 SVPTGIPSSATRLELESNKLQSLPHGVFDKLTQLTKLSLSRNNLVTIKPEMFVNLSRLQC 87 Query: 282 LDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQG 341 L LS+N ++ Q +N Q F L NL +L LS+ + Sbjct: 88 LSLSHNSIA-------QAVNGSQ------------------FLPLTNLQVLDLSHNKLDL 122 Query: 342 SIPKSLTRLNSLRVLHLEGN----NLTGEIPLEFRDVKHLSELR 381 KS + L L+ L L N ++ G I F V HLS L+ Sbjct: 123 YHWKSFSELPQLQALDLSYNSQPFSMKG-IGHNFSFVTHLSMLQ 165 Score = 31.6 bits (70), Expect = 0.87, Method: Compositional matrix adjust. Identities = 51/154 (33%), Positives = 66/154 (42%), Gaps = 16/154 (10%) Query: 159 SSLQTLVLRENGFLGPIP-DELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGN 217 S LQ L L N + + LTNL+VLDL N L+ SF+ L++LDLS N Sbjct: 83 SRLQCLSLSHNSIAQAVNGSQFLPLTNLQVLDLSHNKLDLYHWKSFSELPQLQALDLSYN 142 Query: 218 RLTGSIPG------FV--LPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPI 269 S+ G FV L L L L N + V L S S+ +D S N + Sbjct: 143 SQPFSMKGIGHNFSFVTHLSMLQSLSLAHNDIHTRVSSHLNS-NSVRFLDFSGNGMGRMW 201 Query: 270 PES------INRLNQLVLLDLSYNRLSGPFPSSL 297 E L+ L+ LDLS N L P +L Sbjct: 202 DEGGLYLHFFQGLSGLLKLDLSQNNLHILRPQNL 235 >6EZL-A nrPDB Length = 404 Score = 31.6 bits (70), Expect = 0.79, Method: Compositional matrix adjust. Identities = 15/33 (45%), Positives = 20/33 (60%) Query: 403 RKLRLYNNAGLCVNRDSDLDDAFGSKSGSTVRL 435 RK R Y+NA C++ D L+D G+ GS V L Sbjct: 148 RKYRYYDNAKRCIDFDGLLEDLNGAPEGSIVIL 180 >3IBG-A nrPDB Length = 348 Score = 29.6 bits (65), Expect = 3.3, Method: Compositional matrix adjust. Identities = 21/64 (32%), Positives = 31/64 (48%), Gaps = 6/64 (9%) Query: 420 DLDDAFGSKSGSTVRLCDAETSRPA----PSGTVQHL--SREEDGALPDGATDVSSTSKS 473 +L DAFG K G RL D ++ A P+G++Q L S + G P + + + Sbjct: 67 NLSDAFGQKFGKEARLVDGYSNLSAMEIDPNGSIQDLLASGDSQGDDPLAGLGMGNMMQD 126 Query: 474 LGFS 477 L FS Sbjct: 127 LAFS 130 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 5XJX-C nrPDB 552 e-157 1OGQ-A nrPDB 214 7e-56 6O00-A nrPDB 196 3e-50 6HLU-A nrPDB 191 6e-49 5Y3M-A nrPDB 187 9e-48 5Y3K-A nrPDB 179 3e-45 3WPI-A nrPDB 162 4e-40 3ULU-A nrPDB 159 4e-39 5LFN-A nrPDB 157 1e-38 6GFF-I nrPDB 152 4e-37 1XCD-A nrPDB 149 2e-36 3B2D-A nrPDB 149 2e-36 3CIG-A nrPDB 145 5e-35 2V9T-B nrPDB 142 3e-34 4R6F-A nrPDB 137 7e-33 3A7C-A nrPDB 136 2e-32 5D3I-A nrPDB 135 4e-32 2Z80-A nrPDB 135 4e-32 2Z7X-A nrPDB 135 5e-32 3J0A-A nrPDB 129 2e-30 5YQ5-A nrPDB 124 9e-29 2XOT-A nrPDB 118 6e-27 5ZSN-B nrPDB 113 2e-25 3A79-B nrPDB 100 1e-21 Sequences not found previously or not previously below threshold: 4QDH-A nrPDB 131 5e-31 3RG1-A nrPDB 126 3e-29 3T6Q-A nrPDB 125 4e-29 2FT3-A nrPDB 121 6e-28 4R08-A nrPDB 115 6e-26 5MX0-A nrPDB 103 2e-22 3V44-A nrPDB 98 7e-21 6HKW-A nrPDB 98 8e-21 5GY2-A nrPDB 97 2e-20 2Z7X-B nrPDB 84 2e-16 5Y31-B nrPDB 78 1e-14 4PUF-A nrPDB 74 9e-14 1M9S-A nrPDB 74 1e-13 4ECN-A nrPDB 72 8e-13 4AY9-X nrPDB 71 2e-12 3G06-A nrPDB 68 1e-11 1XWD-C nrPDB 67 2e-11 4PEQ-B nrPDB 67 2e-11 6J5T-G nrPDB 66 4e-11 2BNH-A nrPDB 59 3e-09 5YXM-A nrPDB 59 3e-09 3G04-C nrPDB 58 1e-08 3CVR-A nrPDB 57 1e-08 5KH1-A nrPDB 57 2e-08 2Q4G-W nrPDB 57 3e-08 1JL5-A nrPDB 55 7e-08 1DCE-A nrPDB 54 1e-07 3TSR-E nrPDB 53 3e-07 4PBW-B nrPDB 51 1e-06 3JB9-j nrPDB 50 3e-06 6ICZ-o nrPDB 48 1e-05 4PBV-A nrPDB 46 4e-05 2IFG-A nrPDB 46 5e-05 4WYK-A nrPDB 45 6e-05 1KOH-A nrPDB 44 2e-04 4K17-A nrPDB 43 2e-04 2CA6-A nrPDB 43 2e-04 4NUY-A nrPDB 42 6e-04 5LJ5-W nrPDB 40 0.003 6FE8-D nrPDB 39 0.006 6MDV-A nrPDB 37 0.018 2P1O-B nrPDB 34 0.14 1K0G-A nrPDB 34 0.22 2B3T-A nrPDB 32 0.82 2JAN-A nrPDB 31 1.2 1EDZ-A nrPDB 30 3.0 5XC2-A nrPDB 30 3.0 6QE6-A nrPDB 30 3.1 2A90-A nrPDB 29 3.6 5UOT-0 nrPDB 29 3.8 1PU7-A nrPDB 29 6.1 5X7V-A nrPDB 29 6.8 >5XJX-C nrPDB Length = 433 Score = 552 bits (1421), Expect = e-157, Method: Composition-based stats. Identities = 433/433 (100%), Positives = 433/433 (100%) Query: 28 TSDSTAPSALIDGPQTGFTMTNDGARTEPDEQDAVYDIMRATGNDWAAAIPDVCRGRWHG 87 TSDSTAPSALIDGPQTGFTMTNDGARTEPDEQDAVYDIMRATGNDWAAAIPDVCRGRWHG Sbjct: 1 TSDSTAPSALIDGPQTGFTMTNDGARTEPDEQDAVYDIMRATGNDWAAAIPDVCRGRWHG 60 Query: 88 IECMPDQDNVYHVVSLSFGALSDDTAFPTCDPQRSYVSESLTRLKHLKALFFYRCLGRAP 147 IECMPDQDNVYHVVSLSFGALSDDTAFPTCDPQRSYVSESLTRLKHLKALFFYRCLGRAP Sbjct: 61 IECMPDQDNVYHVVSLSFGALSDDTAFPTCDPQRSYVSESLTRLKHLKALFFYRCLGRAP 120 Query: 148 QRIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFS 207 QRIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFS Sbjct: 121 QRIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFS 180 Query: 208 GLRSLDLSGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTG 267 GLRSLDLSGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTG Sbjct: 181 GLRSLDLSGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTG 240 Query: 268 PIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLK 327 PIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLK Sbjct: 241 PIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLK 300 Query: 328 NLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLNDNSL 387 NLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLNDNSL Sbjct: 301 NLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLNDNSL 360 Query: 388 TGPVPFERDTVWRMRRKLRLYNNAGLCVNRDSDLDDAFGSKSGSTVRLCDAETSRPAPSG 447 TGPVPFERDTVWRMRRKLRLYNNAGLCVNRDSDLDDAFGSKSGSTVRLCDAETSRPAPSG Sbjct: 361 TGPVPFERDTVWRMRRKLRLYNNAGLCVNRDSDLDDAFGSKSGSTVRLCDAETSRPAPSG 420 Query: 448 TVQHLSREEDGAL 460 TVQHLSREEDGAL Sbjct: 421 TVQHLSREEDGAL 433 >1OGQ-A nrPDB Length = 313 Score = 214 bits (545), Expect = 7e-56, Method: Composition-based stats. Identities = 95/350 (27%), Positives = 143/350 (40%), Gaps = 55/350 (15%) Query: 55 EPDEQDAVYDIMRATGN-----DWAAAIPDVCRGRWHGIECMPDQDNVYHVVSLSFGALS 109 P ++ A+ I + GN W D C W G+ C D Y V +L L+ Sbjct: 4 NPQDKQALLQIKKDLGNPTTLSSWLPTT-DCCNRTWLGVLCDTDTQ-TYRVNNLDLSGLN 61 Query: 110 DDTAFPTCDPQRSYVSESLTRLKHLKALFFYRCLGRAPQRIPAFLGRLGSSLQTLVLREN 169 +P + SL L +L L+ N Sbjct: 62 LPKPYP--------IPSSLANLPYLNFLYIG--------------------------GIN 87 Query: 170 GFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPGFV-- 227 +GPIP + LT L L + +++G+IP ++ L +LD S N L+G++P + Sbjct: 88 NLVGPIPPAIAKLTQLHYLYITHTNVSGAIPDFLSQIKTLVTLDFSYNALSGTLPPSISS 147 Query: 228 LPALSVLDLNQNLLTGPVPPTLTSCGSLIK-IDLSRNRVTGPIPESINRLNQLVLLDLSY 286 LP L + + N ++G +P + S L + +SRNR+TG IP + LN L +DLS Sbjct: 148 LPNLVGITFDGNRISGAIPDSYGSFSKLFTSMTISRNRLTGKIPPTFANLN-LAFVDLSR 206 Query: 287 NRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKS 346 N L G + Q + L N S KNL L L N I G++P+ Sbjct: 207 NMLEGDASVLFGSDKNTQKIHLAKN---SLAFDLGKVGLSKNLNGLDLRNNRIYGTLPQG 263 Query: 347 LTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLN---DNSLTGPVPF 393 LT+L L L++ NNL GEIP +L ++ +N P Sbjct: 264 LTQLKFLHSLNVSFNNLCGEIPQG----GNLQRFDVSAYANNKCLCGSPL 309 Score = 89.1 bits (219), Expect = 4e-18, Method: Composition-based stats. Identities = 62/247 (25%), Positives = 111/247 (44%), Gaps = 39/247 (15%) Query: 174 PIPDELGNLTNLKVLDLH-KNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPGFVLP--A 230 PIP L NL L L + N+L G IP + + + L L ++ ++G+IP F+ Sbjct: 67 PIPSSLANLPYLNFLYIGGINNLVGPIPPAIAKLTQLHYLYITHTNVSGAIPDFLSQIKT 126 Query: 231 LSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQL-VLLDLSYNRL 289 L LD + N L+G +PP+++S +L+ I NR++G IP+S ++L + +S NRL Sbjct: 127 LVTLDFSYNALSGTLPPSISSLPNLVGITFDGNRISGAIPDSYGSFSKLFTSMTISRNRL 186 Query: 290 SGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTR 349 +G P + L NL + LS ++G Sbjct: 187 TGKIPPTFANL---------------------------NLAFVDLSRNMLEGDASVLFGS 219 Query: 350 LNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLNDNSLTGPVPFERDTVWRMRRKLRLYN 409 + + +HL N+L ++ + K+L+ L L +N + G T+ + +L+ + Sbjct: 220 DKNTQKIHLAKNSLAFDL-GKVGLSKNLNGLDLRNNRIYG-------TLPQGLTQLKFLH 271 Query: 410 NAGLCVN 416 + + N Sbjct: 272 SLNVSFN 278 Score = 64.8 bits (156), Expect = 9e-11, Method: Composition-based stats. Identities = 42/164 (25%), Positives = 74/164 (45%), Gaps = 10/164 (6%) Query: 278 QLVLLDLSYNRLSGPFP--SSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLS 335 ++ LDLS L P+P SSL L L L + G IP A L L L ++ Sbjct: 51 RVNNLDLSGLNLPKPYPIPSSLANLPYLNFLYIGGINNLVGPIPP-AIAKLTQLHYLYIT 109 Query: 336 NTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLNDNSLTGPVPFER 395 +TN+ G+IP L+++ +L L N L+G +P + +L + + N ++G +P Sbjct: 110 HTNVSGAIPDFLSQIKTLVTLDFSYNALSGTLPPSISSLPNLVGITFDGNRISGAIPDSY 169 Query: 396 DTVWRMRRKLRLYNNAGLCVNRDS-DLDDAFGSKSGSTVRLCDA 438 + +L+ + + NR + + F + + + V L Sbjct: 170 GSFS------KLFTSMTISRNRLTGKIPPTFANLNLAFVDLSRN 207 >6O00-A nrPDB Length = 820 Score = 196 bits (497), Expect = 3e-50, Method: Composition-based stats. Identities = 77/298 (25%), Positives = 128/298 (42%), Gaps = 26/298 (8%) Query: 116 TCDPQRSYVSESLTRLKHLKALFFYRCLGRAPQRIPAFLGRLGSSLQTLVLRENGFLGPI 175 + + R V + L LK LK L L + PQ + +G LQ L + G + Sbjct: 528 SAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVV----TDVGVHLQKLSINNEGTKLIV 583 Query: 176 PDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTG---SIPGFVLPALS 232 + L + NL L+L + L F+ L+ +DL N L I L L+ Sbjct: 584 LNSLKKMVNLTELELIRCDLERIPHSIFS-LHNLQEIDLKDNNLKTIEEIISFQHLHRLT 642 Query: 233 VLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSGP 292 L L N + +P + + +L ++ L+RN++ P + +L LDLS+N L+ Sbjct: 643 CLKLWYNHI-AYIPIQIGNLTNLERLYLNRNKIEKI-PTQLFYCRKLRYLDLSHNNLTFL 700 Query: 293 FPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNS 352 P+ + L +LQ L + N +P F+ + L L L N +Q +P + L + Sbjct: 701 -PADIGLLQNLQNLAVTANR--IEALPPELFQC-RKLRALHLGNNVLQS-LPSRVGELTN 755 Query: 353 LRVLHLEGNNLT------GEIPLEFRDVKHLSELRLNDNSLTGPVPFERDTVWRMRRK 404 L + L GN L GE PL R S L + ++ + P ++ +WR ++ Sbjct: 756 LTQIELRGNRLECLPVELGECPLLKR-----SGLVVEEDLFSTLPPEVKERLWRADKE 808 Score = 66.3 bits (160), Expect = 3e-11, Method: Composition-based stats. Identities = 58/287 (20%), Positives = 95/287 (33%), Gaps = 15/287 (5%) Query: 161 LQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLT 220 L+ L L L + L L+LH L+G F+ L L L Sbjct: 402 LRQLNLNNEWTLDKLRQRLTK-NAQDKLELHLFMLSGIPDTVFD-LVELEVLKLELIPDV 459 Query: 221 GSIPG-FVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQL 279 P L L L L P +L + + + P I L L Sbjct: 460 TIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEI-PLWIYSLKTL 518 Query: 280 VLLDLSYNRLSGPFPS--SLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNT 337 L L+ N LS + GL L+ L + + +P+ +L L ++N Sbjct: 519 EELHLTGN-LSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNE 577 Query: 338 NIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLNDNSLTGPVPFERDT 397 + + SL ++ +L L L +L IP + +L E+ L DN+L Sbjct: 578 GTKLIVLNSLKKMVNLTELELIRCDLER-IPHSIFSLHNLQEIDLKDNNLKTIEEIISFQ 636 Query: 398 VWRMRRKLRL-YNNAGLCVNRDSDLDDAFGSKSGSTVRLCDAETSRP 443 L+L YN+ + +L + + L + + Sbjct: 637 HLHRLTCLKLWYNHIAYIPIQIGNLTNLE------RLYLNRNKIEKI 677 >6HLU-A nrPDB Length = 974 Score = 191 bits (485), Expect = 6e-49, Method: Composition-based stats. Identities = 95/329 (28%), Positives = 133/329 (40%), Gaps = 32/329 (9%) Query: 125 SESLTRLKHLKALFFYRCLGRAPQRIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTN 184 L L L L+ R Q +SL L L N P L +L + Sbjct: 106 ISPLASLNSLSMLWLDRN-----QITDIAPLASLNSLSMLWLFGNKISDIAP--LESLKS 158 Query: 185 LKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPGFVLPALSVLDLNQNLLTGP 244 L L L N + PL+ L L LSGN ++ P L +L+ L L+ N +T Sbjct: 159 LTELQLSSNQITDIAPLA--SLKSLTELSLSGNNISDIAPLESLKSLTELSLSSNQITDI 216 Query: 245 VPPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQ 304 P L S SL ++ LS N+++ P + L L L LS N++S P L+ L SL Sbjct: 217 AP--LASLKSLTELSLSSNQISDIAP--LESLKSLTELQLSRNQISDIAP--LESLKSLT 270 Query: 305 ALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLT 364 L L N LK+L L LS I P L LNSL L L GN +T Sbjct: 271 ELQLSSNQIT----DIAPLASLKSLTELQLSRNQISDIAP--LESLNSLSKLWLNGNQIT 324 Query: 365 GEIPLEFRDVKHLSELRLNDNSLTGPVPFERDTVWRMRRKLRLYNNAGLCVNRDSDLDDA 424 PL + L+EL L+ N +T P L+ + L N+ SD+ Sbjct: 325 DIAPL--ASLNSLTELELSSNQITDIAPLA---------SLKSLSTLWLSSNQISDIAPL 373 Query: 425 FGSKSGSTVRLCDAETSRPAPSGTVQHLS 453 +S S + L + S +P ++ L+ Sbjct: 374 ASLESLSELSLSSNQISDISPLASLNSLT 402 Score = 171 bits (432), Expect = 8e-43, Method: Composition-based stats. Identities = 85/291 (29%), Positives = 127/291 (43%), Gaps = 29/291 (9%) Query: 193 NHLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSC 252 N + PL+ + L L L N++T P L +LS+L L N ++ P L S Sbjct: 101 NQITDISPLA--SLNSLSMLWLDRNQITDIAPLASLNSLSMLWLFGNKISDIAP--LESL 156 Query: 253 GSLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNT 312 SL ++ LS N++T P + L L L LS N +S P L+ L SL L L N Sbjct: 157 KSLTELQLSSNQITDIAP--LASLKSLTELSLSGNNISDIAP--LESLKSLTELSLSSNQ 212 Query: 313 KFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFR 372 LK+L L LS+ I P L L SL L L N ++ PLE Sbjct: 213 IT----DIAPLASLKSLTELSLSSNQISDIAP--LESLKSLTELQLSRNQISDIAPLE-- 264 Query: 373 DVKHLSELRLNDNSLTGPVPFERDTVWRMRRKLRLYNNAGLCVNRDSDLDDAFGSKSGST 432 +K L+EL+L+ N +T P L+ L N+ SD+ S S Sbjct: 265 SLKSLTELQLSSNQITDIAPLA---------SLKSLTELQLSRNQISDIAPLESLNSLSK 315 Query: 433 VRLCDAETSRPAPSGTVQHLSREEDGALPDGATDVS--STSKSLGFSYLSA 481 + L + + AP ++ L+ E + + TD++ ++ KSL +LS+ Sbjct: 316 LWLNGNQITDIAPLASLNSLTELELSS--NQITDIAPLASLKSLSTLWLSS 364 Score = 83.7 bits (205), Expect = 2e-16, Method: Composition-based stats. Identities = 47/186 (25%), Positives = 68/186 (36%), Gaps = 31/186 (16%) Query: 128 LTRLKHLKALFFYRCLGRAPQRIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLKV 187 L LK L L R Q SL L L N P L +L +L Sbjct: 241 LESLKSLTELQLSRN-----QISDIAPLESLKSLTELQLSSNQITDIAP--LASLKSLTE 293 Query: 188 LDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPP 247 L L +N ++ P + L L L+GN++T P L +L+ L+L+ N +T P Sbjct: 294 LQLSRNQISDIAP--LESLNSLSKLWLNGNQITDIAPLASLNSLTELELSSNQITDIAP- 350 Query: 248 TLTSCGSLIKIDLSRNRVTGPIP--------------------ESINRLNQLVLLDLSYN 287 L S SL + LS N+++ P + LN L D+ N Sbjct: 351 -LASLKSLSTLWLSSNQISDIAPLASLESLSELSLSSNQISDISPLASLNSLTGFDVRRN 409 Query: 288 RLSGPF 293 + Sbjct: 410 PIKRLP 415 Score = 42.8 bits (99), Expect = 3e-04, Method: Composition-based stats. Identities = 38/204 (18%), Positives = 59/204 (28%), Gaps = 39/204 (19%) Query: 102 SLSFGALSDDTAFPTCDPQRSYVSES--------LTRLKHLKALFFYRCLGRAPQRIPAF 153 LS +SD + S L LK L L R Q Sbjct: 251 QLSRNQISDIAPLESLKSLTELQLSSNQITDIAPLASLKSLTELQLSRN-----QISDIA 305 Query: 154 LGRLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLD 213 +SL L L N P L +L +L L+L N + PL+ L +L Sbjct: 306 PLESLNSLSKLWLNGNQITDIAP--LASLNSLTELELSSNQITDIAPLA--SLKSLSTLW 361 Query: 214 L----------------------SGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTS 251 L S N+++ P L +L+ D+ +N + Sbjct: 362 LSSNQISDIAPLASLESLSELSLSSNQISDISPLASLNSLTGFDVRRNPIKRLPETITGF 421 Query: 252 CGSLIKIDLSRNRVTGPIPESINR 275 ++ D S + + Sbjct: 422 DMEILWNDFSSSGFITFFDNPLES 445 >5Y3M-A nrPDB Length = 801 Score = 187 bits (475), Expect = 9e-48, Method: Composition-based stats. Identities = 90/359 (25%), Positives = 141/359 (39%), Gaps = 51/359 (14%) Query: 100 VVSLSFGALSDDTAFPTCDPQRSYVSESLTRLKHLKALFFYRCLGRAPQRIPAFLGRLGS 159 + L LS++ + + LT+L+ L F Y A Sbjct: 286 LGRLQVLDLSENFLYDYITKTTIF--NDLTQLRRLNLSFNYHKKVSFAHLHLASSFGSLV 343 Query: 160 SLQTLVLR---ENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSG 216 SL+ L + L L L+ L L N +N + F F L +DLS Sbjct: 344 SLEKLDMHGIFFRSLTNITLQSLTRLPKLQSLHLQLNFINQAQLSIFGAFPSLLFVDLSD 403 Query: 217 NRLTGSIP-----GFVLPALSVLDLNQNLLTGPVPPT-----LTSCGSLIKIDLSRNRVT 266 NR++G+ G V + V L + L GP+ + SC +DLSRN + Sbjct: 404 NRISGAATPAAALGEVDSRVEVWRLPRGLAPGPLDAVSSKDFMPSCNLNFTLDLSRNNLV 463 Query: 267 GPIPESINRLNQLVL-------------------------LDLSYNRLSGPFPSSLQGLN 301 E RL++L LDLS+N+L S L Sbjct: 464 TIQQEMFTRLSRLQCLRLSHNSISQAVNGSQFVPLTSLRVLDLSHNKLDLYHGRSFTELP 523 Query: 302 SLQALMLKGNT-KFSTTI---PENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLH 357 L+AL L N+ FS + L +L L L++ I + + L+ SLR L Sbjct: 524 QLEALDLSYNSQPFSMQGVGHNLSFVAQLPSLRYLSLAHNGIHSRVSQKLSS-ASLRALD 582 Query: 358 LEGNNLT-----GEIPLE-FRDVKHLSELRLNDNSLTGPVPFERDTVWRMRRKLRLYNN 410 GN+L+ G++ L F+ +++L +L L++N L +P D + + R+LRL +N Sbjct: 583 FSGNSLSQMWAEGDLYLCFFKGLRNLVQLDLSENHLHTLLPRHLDNLPKSLRQLRLRDN 641 Score = 159 bits (402), Expect = 2e-39, Method: Composition-based stats. Identities = 80/296 (27%), Positives = 112/296 (37%), Gaps = 19/296 (6%) Query: 131 LKHLKALFFYRCLGRAPQRIPAFLGRLGSSLQTLVLRENGFLGPIP-DELGNLTNLKVLD 189 + F I + S LQ L L N + + LT+L+VLD Sbjct: 446 MPSCNLNFTLDLSRNNLVTIQQEMFTRLSRLQCLRLSHNSISQAVNGSQFVPLTSLRVLD 505 Query: 190 LHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPG--------FVLPALSVLDLNQNLL 241 L N L+ SF L +LDLS N S+ G LP+L L L N + Sbjct: 506 LSHNKLDLYHGRSFTELPQLEALDLSYNSQPFSMQGVGHNLSFVAQLPSLRYLSLAHNGI 565 Query: 242 TGPVPPTLTSCGSLIKIDLSRNRVTGPIPES------INRLNQLVLLDLSYNRLSGPFPS 295 V L+S SL +D S N ++ E L LV LDLS N L P Sbjct: 566 HSRVSQKLSS-ASLRALDFSGNSLSQMWAEGDLYLCFFKGLRNLVQLDLSENHLHTLLPR 624 Query: 296 SLQGLN-SLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLR 354 L L SL+ L L+ N ++ L L L L+ ++ SL L+ Sbjct: 625 HLDNLPKSLRQLRLRDN--NLAFFNWSSLTVLPRLEALDLAGNQLKALSNGSLPPGIRLQ 682 Query: 355 VLHLEGNNLTGEIPLEFRDVKHLSELRLNDNSLTGPVPFERDTVWRMRRKLRLYNN 410 L + N++ IP F L EL L+ N+L P ++ + L + N Sbjct: 683 KLDVSSNSIGFVIPGFFVRATRLIELNLSANALKTVDPSWFGSLAGTLKILDVSAN 738 Score = 97.2 bits (240), Expect = 1e-20, Method: Composition-based stats. Identities = 66/317 (20%), Positives = 99/317 (31%), Gaps = 60/317 (18%) Query: 128 LTRLKHLKALFFYRCLGRAPQRIP------AFLGRLGSSLQTLVLRENGFLG-------- 173 L+ L+ L + G +P P +L+ L L NG Sbjct: 65 LSNLRVLNLKWNCPPAGLSPMHFPCRMTIEPNTFLAVPTLEELNLSYNGITTVPALPSSL 124 Query: 174 ------------PIPDELGNLTNLKVLDLHKN--HLN------GSIPLSFNRFSGLRSLD 213 P L L+ L + N ++N P + L L Sbjct: 125 VSLSLSHTSILVLGPTHFTGLHALRFLYMDGNCYYMNPCPRALEVAPGALLGLGNLTHLS 184 Query: 214 LSGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRN---------- 263 L N LT +P + P+L L L+ N + P L + +L +D+ N Sbjct: 185 LKYNNLT-EVPRRLPPSLDTLLLSYNHIVTLAPEDLANLTALRVLDVGGNCRRCDHARNP 243 Query: 264 ------RVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTT 317 P++ + L++L L L + L +GL LQ L L N + Sbjct: 244 CRECPKNFPKLHPDTFSHLSRLEGLVLKDSSLYKLEKDWFRGLGRLQVLDLSENFLYDYI 303 Query: 318 IPENAFKGLKNLMILVLSNTNIQGS------IPKSLTRLNSLRVLHLEG---NNLTGEIP 368 F L L L LS + + S L SL L + G +LT Sbjct: 304 TKTTIFNDLTQLRRLNLSFNYHKKVSFAHLHLASSFGSLVSLEKLDMHGIFFRSLTNITL 363 Query: 369 LEFRDVKHLSELRLNDN 385 + L L L N Sbjct: 364 QSLTRLPKLQSLHLQLN 380 Score = 85.2 bits (209), Expect = 6e-17, Method: Composition-based stats. Identities = 66/297 (22%), Positives = 99/297 (33%), Gaps = 62/297 (20%) Query: 148 QRIPAFLGRLG-SSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKN---------HL-- 195 + +P F +++ +L L N + +L+NL+VL+L N H Sbjct: 30 KSVPHFSAGAPRANVTSLSLISNRIHHLHDSDFVHLSNLRVLNLKWNCPPAGLSPMHFPC 89 Query: 196 -NGSIPLSFNRFSGLRSLDLSGNRLTGSIPGFV----------------------LPALS 232 P +F L L+LS N +T L AL Sbjct: 90 RMTIEPNTFLAVPTLEELNLSYNGITTVPALPSSLVSLSLSHTSILVLGPTHFTGLHALR 149 Query: 233 VLDLNQN--------LLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLLDL 284 L ++ N P L G+L + L N +T L L L Sbjct: 150 FLYMDGNCYYMNPCPRALEVAPGALLGLGNLTHLSLKYNNLTEVPRRL---PPSLDTLLL 206 Query: 285 SYNRLSGPFPSSLQGLNSLQALMLKGNTKFST--------------TIPENAFKGLKNLM 330 SYN + P L L +L+ L + GN + + + F L L Sbjct: 207 SYNHIVTLAPEDLANLTALRVLDVGGNCRRCDHARNPCRECPKNFPKLHPDTFSHLSRLE 266 Query: 331 ILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLE--FRDVKHLSELRLNDN 385 LVL ++++ L L+VL L N L I F D+ L L L+ N Sbjct: 267 GLVLKDSSLYKLEKDWFRGLGRLQVLDLSENFLYDYITKTTIFNDLTQLRRLNLSFN 323 Score = 82.5 bits (202), Expect = 3e-16, Method: Composition-based stats. Identities = 60/284 (21%), Positives = 93/284 (32%), Gaps = 65/284 (22%) Query: 184 NLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGN-------------RLTGSIPGFVL-P 229 N+ L L N ++ F S LR L+L N R+T F+ P Sbjct: 43 NVTSLSLISNRIHHLHDSDFVHLSNLRVLNLKWNCPPAGLSPMHFPCRMTIEPNTFLAVP 102 Query: 230 ALSVLDLNQNLLTGPV--------------------PPTLTSCGSLIKIDLSRN------ 263 L L+L+ N +T P T +L + + N Sbjct: 103 TLEELNLSYNGITTVPALPSSLVSLSLSHTSILVLGPTHFTGLHALRFLYMDGNCYYMNP 162 Query: 264 --RVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPEN 321 R P ++ L L L L YN L+ SL L+L N T+ Sbjct: 163 CPRALEVAPGALLGLGNLTHLSLKYNNLTEVPRRL---PPSLDTLLLSYN--HIVTLAPE 217 Query: 322 AFKGLKNLMILVLSNT----------------NIQGSIPKSLTRLNSLRVLHLEGNNLTG 365 L L +L + N P + + L+ L L L+ ++L Sbjct: 218 DLANLTALRVLDVGGNCRRCDHARNPCRECPKNFPKLHPDTFSHLSRLEGLVLKDSSLYK 277 Query: 366 EIPLEFRDVKHLSELRLNDNSLTGPVPFERDTVWRMRRKLRLYN 409 FR + L L L++N L + + T++ +LR N Sbjct: 278 LEKDWFRGLGRLQVLDLSENFLYDYI--TKTTIFNDLTQLRRLN 319 Score = 53.6 bits (127), Expect = 2e-07, Method: Composition-based stats. Identities = 54/250 (21%), Positives = 82/250 (32%), Gaps = 55/250 (22%) Query: 253 GSLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNR----LS--------GPFPSSLQGL 300 ++ + L NR+ L+ L +L+L +N LS P++ + Sbjct: 42 ANVTSLSLISNRIHHLHDSDFVHLSNLRVLNLKWNCPPAGLSPMHFPCRMTIEPNTFLAV 101 Query: 301 NSLQALMLKGN------------------TKFSTTIPENAFKGLKNLMILVLSNT----- 337 +L+ L L N + F GL L L + Sbjct: 102 PTLEELNLSYNGITTVPALPSSLVSLSLSHTSILVLGPTHFTGLHALRFLYMDGNCYYMN 161 Query: 338 ---NIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLNDNSLTGPVPFE 394 P +L L +L L L+ NNLT E+P R L L L+ N + P + Sbjct: 162 PCPRALEVAPGALLGLGNLTHLSLKYNNLT-EVPR--RLPPSLDTLLLSYNHIVTLAPED 218 Query: 395 RDTVWRMRRKLRLYNNAGLCVNRDSDLDDAFGSKSGSTVRLCDAETSRPAPSGTVQHLSR 454 + LR+ + G C D + R C + P T HLSR Sbjct: 219 LANL----TALRVLDVGGNCRRCDHARNPC---------RECPKNFPKLHP-DTFSHLSR 264 Query: 455 EEDGALPDGA 464 E L D + Sbjct: 265 LEGLVLKDSS 274 Score = 42.1 bits (97), Expect = 5e-04, Method: Composition-based stats. Identities = 29/99 (29%), Positives = 38/99 (38%), Gaps = 4/99 (4%) Query: 123 YVSESLTRLKHLKALFFYRCLGRAPQRIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNL 182 + SLT L L+AL G + + G LQ L + N IP Sbjct: 646 FNWSSLTVLPRLEAL---DLAGNQLKALSNGSLPPGIRLQKLDVSSNSIGFVIPGFFVRA 702 Query: 183 TNLKVLDLHKNHLNGSIPLSFNRFS-GLRSLDLSGNRLT 220 T L L+L N L P F + L+ LD+S N L Sbjct: 703 TRLIELNLSANALKTVDPSWFGSLAGTLKILDVSANPLH 741 >5Y3K-A nrPDB Length = 802 Score = 179 bits (453), Expect = 3e-45, Method: Composition-based stats. Identities = 80/292 (27%), Positives = 111/292 (38%), Gaps = 19/292 (6%) Query: 135 KALFFYRCLGRAPQRIPAFLGRLGSSLQTLVLRENGFLGPIP-DELGNLTNLKVLDLHKN 193 F + + S LQ L L N + + LT+L+VLDL N Sbjct: 451 NLSFTLDLSRNNLVTVQPEMFAQLSRLQCLRLSHNSISQAVNGSQFVPLTSLQVLDLSHN 510 Query: 194 HLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPG--------FVLPALSVLDLNQNLLTGPV 245 L+ SF L +LDLS N S+ G LP L L L N + V Sbjct: 511 KLDLYHGRSFTELPRLEALDLSYNSQPFSMRGVGHNLSFVAQLPTLRYLSLAHNGIHSRV 570 Query: 246 PPTLTSCGSLIKIDLSRNRVTGPIPES------INRLNQLVLLDLSYNRLSGPFPSSLQG 299 L S SL +D S N ++ E L L+ LDLS NRL P +L Sbjct: 571 SQQLCS-TSLWALDFSGNSLSQMWAEGDLYLRFFQGLRSLIRLDLSQNRLHTLLPCTLGN 629 Query: 300 LN-SLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHL 358 L SLQ L L+ N + ++ L NL L L+ ++ SL L+ L + Sbjct: 630 LPKSLQLLRLRNN--YLAFFNWSSLTLLPNLETLDLAGNQLKALSNGSLPSGTQLQRLDV 687 Query: 359 EGNNLTGEIPLEFRDVKHLSELRLNDNSLTGPVPFERDTVWRMRRKLRLYNN 410 N++ +P F L EL L+ N+L P + L + N Sbjct: 688 SRNSIIFVVPGFFALATRLRELNLSANALRTVEPSWFGFLAGSLEVLDVSAN 739 Score = 177 bits (448), Expect = 1e-44, Method: Composition-based stats. Identities = 83/360 (23%), Positives = 129/360 (35%), Gaps = 52/360 (14%) Query: 100 VVSLSFGALSDDTAFPTCDPQRSYVSESLTRLKHLKALFFYRCLGRAPQRIPAFLGRLGS 159 + +L+ LS++ + +++ + L +L+ L F Y A Sbjct: 286 LGNLTVLDLSENFLYDCITKTKAF--QGLAQLRRLNLSFNYHKKVSFAHLTLAPSFGSLL 343 Query: 160 SLQTLVLR---ENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSG 216 SLQ L + L L L+ L L N +N + F F GLR +DLS Sbjct: 344 SLQELDMHGIFFRSLSQKTLQPLARLPMLQRLYLQMNFINQAQLGIFKDFPGLRYIDLSD 403 Query: 217 NRLTG------------------------SIPGFVLPALS-----------VLDLNQNLL 241 NR++G + P+ LDL++N L Sbjct: 404 NRISGAVEPVATTGEVDGGKKVWLTSRDLTPGPLDTPSSEDFMPSCKNLSFTLDLSRNNL 463 Query: 242 TGPVPPTLTSCGSLIKIDLSRNRVTG-PIPESINRLNQLVLLDLSYNRLSGPFPSSLQGL 300 P L + LS N ++ L L +LDLS+N+L S L Sbjct: 464 VTVQPEMFAQLSRLQCLRLSHNSISQAVNGSQFVPLTSLQVLDLSHNKLDLYHGRSFTEL 523 Query: 301 NSLQALMLKGNT-KFSTTI---PENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVL 356 L+AL L N+ FS + L L L L++ I + + L SL L Sbjct: 524 PRLEALDLSYNSQPFSMRGVGHNLSFVAQLPTLRYLSLAHNGIHSRVSQQLCS-TSLWAL 582 Query: 357 HLEGNNLTGEI------PLEFRDVKHLSELRLNDNSLTGPVPFERDTVWRMRRKLRLYNN 410 GN+L+ F+ ++ L L L+ N L +P + + + LRL NN Sbjct: 583 DFSGNSLSQMWAEGDLYLRFFQGLRSLIRLDLSQNRLHTLLPCTLGNLPKSLQLLRLRNN 642 Score = 104 bits (260), Expect = 6e-23, Method: Composition-based stats. Identities = 59/255 (23%), Positives = 92/255 (36%), Gaps = 31/255 (12%) Query: 157 LGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKN--------HLNGSIPLSFNRFSG 208 L SSL +L+L L P L L L+ L + N P + Sbjct: 120 LPSSLVSLILSRTNILQLDPTSLTGLHALRFLYMDGNCYYKNPCGRALEVAPGALLGLGN 179 Query: 209 LRSLDLSGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRN----- 263 L L L N LT ++P + P+L L L+ N + P L + +L +D+ N Sbjct: 180 LTHLSLKYNNLT-TVPRSLPPSLEYLLLSYNHIVTLAPEDLANLTALRVLDVGGNCRRCD 238 Query: 264 -----------RVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNT 312 + ++ + L++L L L + L P +GL +L L L N Sbjct: 239 HARNPCVECPHKFPQLHSDTFSHLSRLEGLVLKDSSLYQLNPRWFRGLGNLTVLDLSENF 298 Query: 313 KFSTTIPENAFKGLKNLMILVLSNTN------IQGSIPKSLTRLNSLRVLHLEGNNLTGE 366 + AF+GL L L LS ++ S L SL+ L + G Sbjct: 299 LYDCITKTKAFQGLAQLRRLNLSFNYHKKVSFAHLTLAPSFGSLLSLQELDMHGIFFRSL 358 Query: 367 IPLEFRDVKHLSELR 381 + + L L+ Sbjct: 359 SQKTLQPLARLPMLQ 373 Score = 94.9 bits (234), Expect = 7e-20, Method: Composition-based stats. Identities = 62/284 (21%), Positives = 100/284 (35%), Gaps = 44/284 (15%) Query: 164 LVLRENGFLGPIPDELGNLTNLKVLDLHKN---------HL---NGSIPLSFNRFSGLRS 211 L L N + L+NL+ L+L N H P +F L Sbjct: 47 LSLLSNRIHHLHDSDFAQLSNLQKLNLKWNCPPAGLSPMHFPCHMTIEPNTFLAVPTLEE 106 Query: 212 LDLSGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRN-------- 263 L+LS N +T + +L L L++ + P +LT +L + + N Sbjct: 107 LNLSYNGITTVP--ALPSSLVSLILSRTNILQLDPTSLTGLHALRFLYMDGNCYYKNPCG 164 Query: 264 RVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAF 323 R P ++ L L L L YN L+ S SL+ L+L N T+ Sbjct: 165 RALEVAPGALLGLGNLTHLSLKYNNLTTVPRSL---PPSLEYLLLSYN--HIVTLAPEDL 219 Query: 324 KGLKNLMILVLSNT----------------NIQGSIPKSLTRLNSLRVLHLEGNNLTGEI 367 L L +L + + + L+ L L L+ ++L Sbjct: 220 ANLTALRVLDVGGNCRRCDHARNPCVECPHKFPQLHSDTFSHLSRLEGLVLKDSSLYQLN 279 Query: 368 PLEFRDVKHLSELRLNDNSLTGPVPFERDTVWRM-RRKLRLYNN 410 P FR + +L+ L L++N L + + R+L L N Sbjct: 280 PRWFRGLGNLTVLDLSENFLYDCITKTKAFQGLAQLRRLNLSFN 323 Score = 74.1 bits (180), Expect = 1e-13, Method: Composition-based stats. Identities = 48/179 (26%), Positives = 67/179 (37%), Gaps = 9/179 (5%) Query: 100 VVSLSFGALSDDTAFPTCDPQRSYVSESLTRLKHLKALFFYRCLGRAPQRIPAFLGRLGS 159 + +L F S + D + + L L L R +P LG L Sbjct: 579 LWALDFSGNSLSQMWAEGDLYLRFF-QGLRSLIRLDLSQN-----RLHTLLPCTLGNLPK 632 Query: 160 SLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRL 219 SLQ L LR N L L NL+ LDL N L S + L+ LD+S N + Sbjct: 633 SLQLLRLRNNYLAFFNWSSLTLLPNLETLDLAGNQLKALSNGSLPSGTQLQRLDVSRNSI 692 Query: 220 TGSIPGF--VLPALSVLDLNQNLLTGPVPPTLTSCG-SLIKIDLSRNRVTGPIPESINR 275 +PGF + L L+L+ N L P SL +D+S N + + Sbjct: 693 IFVVPGFFALATRLRELNLSANALRTVEPSWFGFLAGSLEVLDVSANPLHCACGAAFVD 751 >3WPI-A nrPDB Length = 803 Score = 162 bits (409), Expect = 4e-40, Method: Composition-based stats. Identities = 91/369 (24%), Positives = 140/369 (37%), Gaps = 65/369 (17%) Query: 98 YHVVSLSFGALSDDTAFPTCDPQRSYVSESLTRLKHLKALFFYRCLGRAPQRIPAFLGRL 157 +V LS LS++ + + ++ ++LTRL+ L F YR +++ L Sbjct: 284 QGLVQLSVLDLSENFLYESITHTNAF--QNLTRLRKLNLSFNYR------KKVSFARLHL 335 Query: 158 GSSLQTLV----LRENGFLGPIPDE-----LGNLTNLKVLDLHKNHLNGSIPLSFNRFSG 208 SS + LV L NG + ++ L +L L L L N +N + F F Sbjct: 336 ASSFKNLVSLQELNMNGIFFRLLNKYTLRWLADLPKLHTLHLQMNFINQAQLSIFGTFRA 395 Query: 209 LRSLDLSGNRLTG-SIPGFVLPALS----------------------------------- 232 LR +DLS NR++G S P + Sbjct: 396 LRFVDLSDNRISGPSTLSEATPEEADDAEQEELLSADPHPAPLSTPASKNFMDRCKNFKF 455 Query: 233 VLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTG-PIPESINRLNQLVLLDLSYNRLSG 291 +DL++N L P L + LS N + L L +LDLS+N+L Sbjct: 456 TMDLSRNNLVTIKPEMFVQLSRLQCLSLSHNSIAQAVNGSQFLPLTNLQVLDLSHNKLDL 515 Query: 292 PFPSSLQGLNSLQALMLKGNT-KFSTTIPENAFK---GLKNLMILVLSNTNIQGSIPKSL 347 S L LQAL L N+ FS + F L L L L++ +I + L Sbjct: 516 YHWKSFSELPQLQALDLSYNSQPFSMKGIGHQFSFVTHLSMLQSLSLAHNDIHTRVSSHL 575 Query: 348 TRLNSLRVLHLEGNNLTGEI------PLEFRDVKHLSELRLNDNSLTGPVPFERDTVWRM 401 NS+R L GN + F+ + L +L L+ N+L P D + + Sbjct: 576 NS-NSVRFLDFSGNGMGRMWDEGGLYLHFFQGLSGLLKLDLSQNNLHILRPQNLDNLPKS 634 Query: 402 RRKLRLYNN 410 + L L +N Sbjct: 635 LKLLSLRDN 643 Score = 125 bits (314), Expect = 4e-29, Method: Composition-based stats. Identities = 71/291 (24%), Positives = 106/291 (36%), Gaps = 17/291 (5%) Query: 135 KALFFYRCLGRAPQRIPAFLGRLGSSLQTLVLRENGFLGPIP-DELGNLTNLKVLDLHKN 193 F I + S LQ L L N + + LTNL+VLDL N Sbjct: 452 NFKFTMDLSRNNLVTIKPEMFVQLSRLQCLSLSHNSIAQAVNGSQFLPLTNLQVLDLSHN 511 Query: 194 HLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPGF--------VLPALSVLDLNQNLLTGPV 245 L+ SF+ L++LDLS N S+ G L L L L N + V Sbjct: 512 KLDLYHWKSFSELPQLQALDLSYNSQPFSMKGIGHQFSFVTHLSMLQSLSLAHNDIHTRV 571 Query: 246 PPTLTSCGSLIKIDLSRNRVTGPIPES------INRLNQLVLLDLSYNRLSGPFPSSLQG 299 L S S+ +D S N + E L+ L+ LDLS N L P +L Sbjct: 572 SSHLNS-NSVRFLDFSGNGMGRMWDEGGLYLHFFQGLSGLLKLDLSQNNLHILRPQNLDN 630 Query: 300 LNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLE 359 L L+ + + + L NL +L L+ ++ +L L+ L + Sbjct: 631 LPKSLKLLSLR-DNYLSFFNWTSLSFLPNLEVLDLAGNQLKALTQGTLPNGTLLQKLDVS 689 Query: 360 GNNLTGEIPLEFRDVKHLSELRLNDNSLTGPVPFERDTVWRMRRKLRLYNN 410 N++ +P F L E+ L+ N L + L + +N Sbjct: 690 SNSIVSVVPAFFALAVELKEVNLSHNILKTVDRSWFGPIVMQLTVLDVRSN 740 Score = 107 bits (266), Expect = 1e-23, Method: Composition-based stats. Identities = 86/394 (21%), Positives = 129/394 (32%), Gaps = 43/394 (10%) Query: 94 QDNVYHVVSLSFGALSDDTAF------PTCDPQRSYVSESLTRLKHLKALFFYRCLGRAP 147 + ++H+ + F LS+ P + S +T Sbjct: 51 SNRIHHLHNSDFVHLSNLRQLNLKWNCPPTGLSPLHFSCHMTIEPRTFLAMRTLEELNLS 110 Query: 148 QRIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSI-------- 199 + RL SSL L L L + L L +L+VL + N + Sbjct: 111 YNGITTVPRLPSSLVNLSLSHTNILVLDANSLAGLYSLRVLFMDGNCYYKNPCTGAVKVT 170 Query: 200 PLSFNRFSGLRSLDLSGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKID 259 P + S L L L N LT +P + P+L L ++ NL+ P L SL +D Sbjct: 171 PGALLGLSQLTHLSLKYNNLTK-VPRQLPPSLEYLLVSYNLIVKLGPEDLAQLTSLRVLD 229 Query: 260 LSRN----------------RVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSL 303 + N + PE+ + L+ L L L + L S QGL L Sbjct: 230 VGGNCRRCDHAPNPCIECGQKSLHLHPETFHHLSHLEGLVLKDSSLHTLNSSWFQGLVQL 289 Query: 304 QALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGS------IPKSLTRLNSLRVLH 357 L L N + + NAF+ L L L LS + + S L SL+ L+ Sbjct: 290 SVLDLSENFLYESITHTNAFQNLTRLRKLNLSFNYRKKVSFARLHLASSFKNLVSLQELN 349 Query: 358 LEG---NNLTGEIPLEFRDVKHLSELRLNDNSLTGPVPFERDTVWRMRRKLRLYNNAGLC 414 + G L D+ L L L N +R R + L +N Sbjct: 350 MNGIFFRLLNKYTLRWLADLPKLHTLHLQMN-FINQAQLSIFGTFRALRFVDLSDNRISG 408 Query: 415 VNRDSDLDDAFGSKSGSTVRLCDAETSRPAPSGT 448 + S+ + L PAP T Sbjct: 409 PSTLSEATPEEADDAEQEELLSAD--PHPAPLST 440 Score = 87.9 bits (216), Expect = 1e-17, Method: Composition-based stats. Identities = 67/312 (21%), Positives = 105/312 (33%), Gaps = 60/312 (19%) Query: 159 SSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKN---------HLN---GSIPLSFNRF 206 S++ L L N + +L+NL+ L+L N H + P +F Sbjct: 42 SNITRLSLISNRIHHLHNSDFVHLSNLRQLNLKWNCPPTGLSPLHFSCHMTIEPRTFLAM 101 Query: 207 SGLRSLDLSGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRN--- 263 L L+LS N +T + +L L L+ + +L SL + + N Sbjct: 102 RTLEELNLSYNGITTVPR--LPSSLVNLSLSHTNILVLDANSLAGLYSLRVLFMDGNCYY 159 Query: 264 -----RVTGPIPESINRLNQLVLLDLSYNRLSGPF---------------------PSSL 297 P ++ L+QL L L YN L+ P L Sbjct: 160 KNPCTGAVKVTPGALLGLSQLTHLSLKYNNLTKVPRQLPPSLEYLLVSYNLIVKLGPEDL 219 Query: 298 QGLNSLQALMLKGNTKFSTTIP--------------ENAFKGLKNLMILVLSNTNIQGSI 343 L SL+ L + GN + P F L +L LVL ++++ Sbjct: 220 AQLTSLRVLDVGGNCRRCDHAPNPCIECGQKSLHLHPETFHHLSHLEGLVLKDSSLHTLN 279 Query: 344 PKSLTRLNSLRVLHLEGNNLTGEIPLE--FRDVKHLSELRLNDNSLTGPVPFERDTVWRM 401 L L VL L N L I F+++ L +L L+ N V F R + Sbjct: 280 SSWFQGLVQLSVLDLSENFLYESITHTNAFQNLTRLRKLNLSFN-YRKKVSFARLHLASS 338 Query: 402 RRKLRLYNNAGL 413 + L + Sbjct: 339 FKNLVSLQELNM 350 Score = 84.5 bits (207), Expect = 1e-16, Method: Composition-based stats. Identities = 52/226 (23%), Positives = 82/226 (36%), Gaps = 26/226 (11%) Query: 177 DELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPGFVLPALSVLDL 236 + +N+ L L N ++ F S LR L+L N P + P L Sbjct: 36 SAAASCSNITRLSLISNRIHHLHNSDFVHLSNLRQLNLKWN----CPPTGLSP------L 85 Query: 237 NQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSGPFPSS 296 + + P T + +L +++LS N +T + LV L LS+ + +S Sbjct: 86 HFSCHMTIEPRTFLAMRTLEELNLSYNGITTVPRLP----SSLVNLSLSHTNILVLDANS 141 Query: 297 LQGLNSLQALMLKGNTKFS------TTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRL 350 L GL SL+ L + GN + + A GL L L L N+ + Sbjct: 142 LAGLYSLRVLFMDGNCYYKNPCTGAVKVTPGALLGLSQLTHLSLKYNNLTKVPRQL---P 198 Query: 351 NSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLNDNSL---TGPVPF 393 SL L + N + P + + L L + N P P Sbjct: 199 PSLEYLLVSYNLIVKLGPEDLAQLTSLRVLDVGGNCRRCDHAPNPC 244 Score = 59.4 bits (142), Expect = 3e-09, Method: Composition-based stats. Identities = 64/286 (22%), Positives = 99/286 (34%), Gaps = 44/286 (15%) Query: 242 TGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNR----LSGPF---- 293 + P SC ++ ++ L NR+ L+ L L+L +N LS Sbjct: 31 SVPRFSAAASCSNITRLSLISNRIHHLHNSDFVHLSNLRQLNLKWNCPPTGLSPLHFSCH 90 Query: 294 ----PSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTR 349 P + + +L+ L L N + + +L+ L LS+TNI SL Sbjct: 91 MTIEPRTFLAMRTLEELNLSYNGITTVPRLPS------SLVNLSLSHTNILVLDANSLAG 144 Query: 350 LNSLRVLHLEGNNL--------TGEIPLEFRDVKHLSELRLNDNSLTGPVPFERDTVWRM 401 L SLRVL ++GN P + L+ L L N+LT + Sbjct: 145 LYSLRVLFMDGNCYYKNPCTGAVKVTPGALLGLSQLTHLSLKYNNLTKVPR----QLPPS 200 Query: 402 RRKLRLYNNAGLCVNRDSDLDDAFGSKSGSTVRLCDAETSRPAPS------------GTV 449 L + N + + + DL + C P P T Sbjct: 201 LEYLLVSYNLIVKLGPE-DLAQLTSLRVLDVGGNCRRCDHAPNPCIECGQKSLHLHPETF 259 Query: 450 QHLSREEDGALPDGATDVSSTSKSLGFSYLSAFFLVFPNFIFMLIS 495 HLS E L D + ++S G LS L NF++ I+ Sbjct: 260 HHLSHLEGLVLKDSSLHTLNSSWFQGLVQLSVLDLS-ENFLYESIT 304 Score = 50.9 bits (120), Expect = 1e-06, Method: Composition-based stats. Identities = 52/259 (20%), Positives = 75/259 (28%), Gaps = 63/259 (24%) Query: 100 VVSLSFGALSDDTAFPTCDPQRSYVSESLTRLKHLKALFFYRCLGRAPQRIPAFLGRLGS 159 + +L LS + D L +L+ L + + S Sbjct: 500 LTNLQVLDLSHNKL----DLYHWKSFSELPQLQALDLSYNSQPFSMKGIGHQFSFVTHLS 555 Query: 160 SLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNG------SIPLSFNRFSGLRSLD 213 LQ+L L N + L + +++ LD N + F SGL LD Sbjct: 556 MLQSLSLAHNDIHTRVSSHLNS-NSVRFLDFSGNGMGRMWDEGGLYLHFFQGLSGLLKLD 614 Query: 214 LSGNRLTGSIPGFV---------------------------LPALSVLDLNQNLLTGPVP 246 LS N L P + LP L VLDL N L Sbjct: 615 LSQNNLHILRPQNLDNLPKSLKLLSLRDNYLSFFNWTSLSFLPNLEVLDLAGNQLKALTQ 674 Query: 247 PTLTSCGSLIKID------------------------LSRNRVTGPIPESINR-LNQLVL 281 TL + L K+D LS N + + QL + Sbjct: 675 GTLPNGTLLQKLDVSSNSIVSVVPAFFALAVELKEVNLSHNILKTVDRSWFGPIVMQLTV 734 Query: 282 LDLSYNRLSGPFPSSLQGL 300 LD+ N L ++ L Sbjct: 735 LDVRSNPLHCACGAAFVDL 753 >3ULU-A nrPDB Length = 694 Score = 159 bits (401), Expect = 4e-39, Method: Composition-based stats. Identities = 78/343 (22%), Positives = 128/343 (37%), Gaps = 51/343 (14%) Query: 54 TEPDEQDAVYDIMRATGNDWAAAIPDVCRGRWHGIECMPDQDNVYHVVSLSFGALSDDTA 113 T D Y+ + GND A +P + + +E +N+ H+ S S L + Sbjct: 258 TNLTMLDLSYNNLNVVGNDSFAWLPQL---EYFFLE----YNNIQHLFSHSLHGLFNVRY 310 Query: 114 FPTCDPQRSYVSESLTRLKHLKALFFYRCLGRAPQRIPAFLGRLGSSLQTLVLRENGFLG 173 + +RS+ +S++ L P +I F + L+ L + +N G Sbjct: 311 L---NLKRSFTKQSIS-------------LASLP-KIDDFSFQWLKCLEHLNMEDNDIPG 353 Query: 174 PIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPGFVLPALSV 233 + L NLK L L + S + + L+ + L + Sbjct: 354 IKSNMFTGLINLKYLSLSNSF------TSLRTLTNETFVSLAHSPLH------------I 395 Query: 234 LDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRV-TGPIPESINRLNQLVLLDLSYNRLSGP 292 L+L +N ++ + G L +DL N + + L + + LSYN+ Sbjct: 396 LNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKYLQL 455 Query: 293 FPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNS 352 +S + SLQ LML+ + + F+ L+NL IL LSN NI L L Sbjct: 456 TRNSFALVPSLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEGLEK 515 Query: 353 LRVLHLEGNNLTGEIPLE--------FRDVKHLSELRLNDNSL 387 L +L L+ NNL + + HL L L N Sbjct: 516 LEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHILNLESNGF 558 Score = 121 bits (302), Expect = 9e-28, Method: Composition-based stats. Identities = 72/253 (28%), Positives = 108/253 (42%), Gaps = 11/253 (4%) Query: 172 LGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPGFV--LP 229 L +PD+L TN+ VL+L N L +F R+S L SLD+ N ++ P LP Sbjct: 26 LTQVPDDLP--TNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNTISKLEPELCQKLP 83 Query: 230 ALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRL 289 L VL+L N L+ T C +L ++ L N + + L+ LDLS+N L Sbjct: 84 MLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQKNLITLDLSHNGL 143 Query: 290 SGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTR 349 S + L +LQ L+L N + E +L L LS+ I+ P Sbjct: 144 SSTKLGTQVQLENLQELLLSNNKIQALKSEELDIFANSSLKKLELSSNQIKEFSPGCFHA 203 Query: 350 LNSLRVLHLE----GNNLTGEIPLEFRDVKHLSELRLNDNSLTGPVPFE-RDTVWRMRRK 404 + L L L G +LT ++ LE + + L L+++ L+ W Sbjct: 204 IGRLFGLFLNNVQLGPSLTEKLCLELAN-TSIRNLSLSNSQLSTTSNTTFLGLKWTNLTM 262 Query: 405 LRL-YNNAGLCVN 416 L L YNN + N Sbjct: 263 LDLSYNNLNVVGN 275 Score = 97.2 bits (240), Expect = 2e-20, Method: Composition-based stats. Identities = 65/304 (21%), Positives = 108/304 (35%), Gaps = 11/304 (3%) Query: 148 QRIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFS 207 +R+PA S L +L + N P+ L LKVL+L N L+ +F + Sbjct: 48 RRLPAANFTRYSQLTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNELSQLSDKTFAFCT 107 Query: 208 GLRSLDLSGNRLTGSI--PGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRV 265 L L L N + P L LDL+ N L+ T +L ++ LS N++ Sbjct: 108 NLTELHLMSNSIQKIKNNPFVKQKNLITLDLSHNGLSSTKLGTQVQLENLQELLLSNNKI 167 Query: 266 TGPIPE--SINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAF 323 E I + L L+LS N++ P + L L L + + Sbjct: 168 QALKSEELDIFANSSLKKLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCL 227 Query: 324 KGL-KNLMILVLSNTNIQGSIPKSLTRL--NSLRVLHLEGNNLTGEIPLEFRDVKHLSEL 380 + ++ L LSN+ + + + L +L +L L NNL F + L Sbjct: 228 ELANTSIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYF 287 Query: 381 RLNDNSLTGPV--PFERDTVWRMRRKLRLYNNAGLCVNRDSDLDD--AFGSKSGSTVRLC 436 L N++ R R + + + +DD K + + Sbjct: 288 FLEYNNIQHLFSHSLHGLFNVRYLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNME 347 Query: 437 DAET 440 D + Sbjct: 348 DNDI 351 Score = 91.4 bits (225), Expect = 8e-19, Method: Composition-based stats. Identities = 63/286 (22%), Positives = 100/286 (34%), Gaps = 18/286 (6%) Query: 114 FPTCDPQRSYVSESLTRLKHLKALFFYRCLG-----RAPQRIPAFLGRLGSSLQTLVLRE 168 PT + L RL + + ++ L + L+ L L+ Sbjct: 33 LPTNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNTISKLEPELCQKLPMLKVLNLQH 92 Query: 169 NGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPGFV- 227 N TNL L L N + F + L +LDLS N L+ + G Sbjct: 93 NELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQKNLITLDLSHNGLSSTKLGTQV 152 Query: 228 -LPALSVLDLNQNLLTGPVPPTLTSCGS--LIKIDLSRNRVTGPIPESINRLNQLVLLDL 284 L L L L+ N + L + L K++LS N++ P + + +L L L Sbjct: 153 QLENLQELLLSNNKIQALKSEELDIFANSSLKKLELSSNQIKEFSPGCFHAIGRLFGLFL 212 Query: 285 SYNRLSGPFPSSLQGL------NSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTN 338 + +L PS + L S++ L L + +T+ NL +L LS N Sbjct: 213 NNVQLG---PSLTEKLCLELANTSIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNN 269 Query: 339 IQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLND 384 + S L L LE NN+ + ++ L L Sbjct: 270 LNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNLKR 315 Score = 88.3 bits (217), Expect = 7e-18, Method: Composition-based stats. Identities = 66/314 (21%), Positives = 116/314 (36%), Gaps = 44/314 (14%) Query: 183 TNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPGFVL-----PALSVLDLN 237 ++LK L+L N + P F+ L L L+ +L S+ + ++ L L+ Sbjct: 181 SSLKKLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLS 240 Query: 238 QNLLTGPVPPTLTSCG--SLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSGPFPS 295 + L+ T +L +DLS N + +S L QL L YN + F Sbjct: 241 NSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSH 300 Query: 296 SLQGLNSLQALMLKGNTKFST-------TIPENAFKGLKNLMILVLSNTNIQGSIPKSLT 348 SL GL +++ L LK + + I + +F+ LK L L + + +I G T Sbjct: 301 SLHGLFNVRYLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFT 360 Query: 349 RLNSL----------------------------RVLHLEGNNLTGEIPLEFRDVKHLSEL 380 L +L +L+L N ++ F + HL L Sbjct: 361 GLINLKYLSLSNSFTSLRTLTNETFVSLAHSPLHILNLTKNKISKIESDAFSWLGHLEVL 420 Query: 381 RLNDNSLTGPVPFERDTVWRMRRKLRLYNNAGLCVNRDSDLDDAFGSKSGSTVRLC-DAE 439 L N + + + ++ L N L + R+S + R+ Sbjct: 421 DLGLNEIGQELTGQEWRGLENIFEIYLSYNKYLQLTRNS-FALVPSLQRLMLRRVALKNV 479 Query: 440 TSRPAPSGTVQHLS 453 S P+P +++L+ Sbjct: 480 DSSPSPFQPLRNLT 493 Score = 76.0 bits (185), Expect = 3e-14, Method: Composition-based stats. Identities = 55/235 (23%), Positives = 87/235 (37%), Gaps = 17/235 (7%) Query: 116 TCDPQRSYVSESLTRLKHLKALFFYRCLGRAPQRIPAFLGRLGSSLQTLVLRENGFLGPI 175 T + S++ + L HL+ L L Q + R ++ + L N +L Sbjct: 399 TKNKISKIESDAFSWLGHLEVLDL--GLNEIGQELTGQEWRGLENIFEIYLSYNKYLQLT 456 Query: 176 PDELGNLTNLKVLDLHKNHLN--GSIPLSFNRFSGLRSLDLSGNRLTGSIPGFV--LPAL 231 + + +L+ L L + L S P F L LDLS N + + L L Sbjct: 457 RNSFALVPSLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEGLEKL 516 Query: 232 SVLDLNQNLL----TGPVPPT----LTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLLD 283 +LDL N L P L L ++L N E L +L ++D Sbjct: 517 EILDLQHNNLARLWKHANPGGPIYFLKGLSHLHILNLESNGFDEIPVEVFKDLFELKIID 576 Query: 284 LSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKG-LKNLMILVLSNT 337 L N L+ S SL++L L+ N T++ + F +NL L + Sbjct: 577 LGLNNLNTLPASVFNNQVSLKSLNLQKN--LITSVEKKVFGPAFRNLTELDMRFN 629 >5LFN-A nrPDB Length = 337 Score = 157 bits (396), Expect = 1e-38, Method: Composition-based stats. Identities = 60/240 (25%), Positives = 100/240 (41%), Gaps = 7/240 (2%) Query: 149 RIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSG 208 + A R +L +L L+ L L L L N + +F+ + Sbjct: 43 VLAANSFRAMPNLVSLHLQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVLRAGAFDDLTE 102 Query: 209 LRSLDLSGNRLTGSIPGFVLP--ALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVT 266 L L L N++T G + P L +L LN N + L + LS N ++ Sbjct: 103 LTYLYLDHNKVTELPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWLYLSENALS 162 Query: 267 GPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGL 326 P +++ + L + N+LS ++L L ++ L L N +IP+NAF+ Sbjct: 163 SLQPGALDDVENLAKFHVDRNQLSSYPSAALSKLRVVEELKLSHNP--LKSIPDNAFQSF 220 Query: 327 -KNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLNDN 385 + L L L NTN++ + + +L+ +HLE N L ++P F L L L +N Sbjct: 221 GRYLETLWLDNTNLEKFSDGAFLGVTTLKHVHLENNRL-NQLPSNFPFD-SLETLALTNN 278 Score = 120 bits (300), Expect = 1e-27, Method: Composition-based stats. Identities = 45/184 (24%), Positives = 78/184 (42%), Gaps = 3/184 (1%) Query: 227 VLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLLDLSY 286 V +L+L +N + + +L+ + L ++ + L QL+ L LS+ Sbjct: 27 VSEKTKLLNLQRNNFPVLAANSFRAMPNLVSLHLQHCQIREVAAGAFRGLKQLIYLYLSH 86 Query: 287 NRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKS 346 N + + L L L L N T +P L NL IL L+N I+ + Sbjct: 87 NDIRVLRAGAFDDLTELTYLYLDHNK--VTELPRGLLSPLVNLFILQLNNNKIRELRAGA 144 Query: 347 LTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLNDNSLTGPVPFERDTVWRMRRKLR 406 LR L+L N L+ P DV++L++ ++ N L+ P + R+ +L+ Sbjct: 145 FQGAKDLRWLYLSENALSSLQPGALDDVENLAKFHVDRNQLSS-YPSAALSKLRVVEELK 203 Query: 407 LYNN 410 L +N Sbjct: 204 LSHN 207 Score = 106 bits (265), Expect = 2e-23, Method: Composition-based stats. Identities = 51/244 (20%), Positives = 86/244 (35%), Gaps = 5/244 (2%) Query: 212 LDLSGNRLTGSIPGFV--LPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPI 269 L+L N +P L L L + LI + LS N + Sbjct: 34 LNLQRNNFPVLAANSFRAMPNLVSLHLQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVLR 93 Query: 270 PESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNL 329 + + L +L L L +N+++ L L +L L L N + AF+G K+L Sbjct: 94 AGAFDDLTELTYLYLDHNKVTELPRGLLSPLVNLFILQLNNNK--IRELRAGAFQGAKDL 151 Query: 330 MILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLNDNSLTG 389 L LS + P +L + +L H++ N L+ ++ + EL+L+ N L Sbjct: 152 RWLYLSENALSSLQPGALDDVENLAKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKS 211 Query: 390 PVPFERDTVWRMRRKLRLYNNAGLCVNRDSDLDDAFGSKSGSTVRLCDAETSRPAPSGTV 449 + R L L +N L D K + P ++ Sbjct: 212 IPDNAFQSFGRYLETLWL-DNTNLEKFSDGAFLGVTTLKHVHLENNRLNQLPSNFPFDSL 270 Query: 450 QHLS 453 + L+ Sbjct: 271 ETLA 274 Score = 70.2 bits (170), Expect = 2e-12, Method: Composition-based stats. Identities = 39/224 (17%), Positives = 74/224 (33%), Gaps = 27/224 (12%) Query: 94 QDNVYHVVSLSFGALSDDTAFPTCDPQRSYVSESLTRLKHLKALFFYRCLGRAPQRIPAF 153 +++ + + +F L++ T + + + L L L LF + + + A Sbjct: 86 HNDIRVLRAGAFDDLTELTYLYLDHNKVTELPRGL--LSPLVNLFILQLNNNKIRELRAG 143 Query: 154 LGRLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLD 213 + L+ L L EN P L ++ NL + +N L+ + ++ Sbjct: 144 AFQGAKDLRWLYLSENALSSLQPGALDDVENLAKFHVDRNQLSSYPSAALSKLR------ 197 Query: 214 LSGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGS-LIKIDLSRNRVTGPIPES 272 + L L+ N L S G L + L + + Sbjct: 198 ----------------VVEELKLSHNPLKSIPDNAFQSFGRYLETLWLDNTNLEKFSDGA 241 Query: 273 INRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFST 316 + L + L NRL+ + +SL+ L L N T Sbjct: 242 FLGVTTLKHVHLENNRLNQLPSNF--PFDSLETLALTNNPWKCT 283 >6GFF-I nrPDB Length = 618 Score = 152 bits (383), Expect = 4e-37, Method: Composition-based stats. Identities = 91/341 (26%), Positives = 123/341 (36%), Gaps = 63/341 (18%) Query: 127 SLTRLKHLKALFFYRCLGRAPQRIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLK 186 L L + +L + L SL TL L EN ++ L+ Sbjct: 100 GLGPLPRVTSLDLSGN--SLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALE 157 Query: 187 VLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPGFVLPALSVLDLNQNLLTG--- 243 LDLH N L +F L L+LS N LT I F L L VLDL+ N + Sbjct: 158 QLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLT-CISDFSLQQLRVLDLSCNSIEAFQT 216 Query: 244 --------------------PVPPTLTSCGSLIKIDLSRNRV---TGPIPESIN------ 274 P L + LI ++LS N + TGP +S Sbjct: 217 ASQPQAEFQLTWLDLRENKLLHFPDLAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSE 276 Query: 275 -----------------RLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTT 317 L+QL+ LDLSYN + S L+ L SL L L N T Sbjct: 277 GWSALPLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNC--LRT 334 Query: 318 IPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHL 377 L LM+L LS+ ++ ++ L SLR L L+GN L P F ++ L Sbjct: 335 FEARRLGSLPCLMLLDLSHNALE-TLELGARALGSLRTLLLQGNALRDLPPYTFANLASL 393 Query: 378 SELRLNDNSLT--------GPVPFERDTVWRMRRKLRLYNN 410 L L N ++ GP + R L L +N Sbjct: 394 QRLNLQGNRVSPCGGPDEPGPSGCVAFSGITSLRSLSLVDN 434 Score = 110 bits (274), Expect = 2e-24, Method: Composition-based stats. Identities = 76/386 (19%), Positives = 114/386 (29%), Gaps = 85/386 (22%) Query: 136 ALFFYRCLGRAPQRIPAFLGRLGSSLQTLVLRE--------------------------- 168 AL + + + L+ L L Sbjct: 55 ALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSG 114 Query: 169 -------------------------NGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSF 203 N ++ L+ LDLH N L +F Sbjct: 115 NSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAF 174 Query: 204 NRFSGLRSLDLSGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCG-SLIKIDLSR 262 L L+LS N LT I F L L VLDL+ N + + L +DL Sbjct: 175 EGLPRLTHLNLSRNSLT-CISDFSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRE 233 Query: 263 NRVTGPIPESINRLNQLVLLDLSYNRLSGP------------------------FPSSLQ 298 N++ + L +L+ L+LS N + P + Sbjct: 234 NKLLHFPD--LAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNAS 291 Query: 299 GLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHL 358 G Q L L + IP++ + L +L L LS ++ + L L L +L L Sbjct: 292 GRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDL 351 Query: 359 EGNNLTGEIPLEFRDVKHLSELRLNDNSLTGPVPFERDTVWRMRRKLRLYNNAGLCVNRD 418 N L R + L L L N+L P+ + ++R N C D Sbjct: 352 SHNALETLELGA-RALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPD 410 Query: 419 ----SDLDDAFGSKSGSTVRLCDAET 440 S G S ++ L D E Sbjct: 411 EPGPSGCVAFSGITSLRSLSLVDNEI 436 Score = 109 bits (273), Expect = 2e-24, Method: Composition-based stats. Identities = 77/324 (23%), Positives = 116/324 (35%), Gaps = 42/324 (12%) Query: 143 LGRAPQRIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLS 202 L + P +P +TL L N + LG T L+ LDL N ++ P + Sbjct: 21 LLQVPSVLPPDT-------ETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGA 73 Query: 203 FNRFSGLRSLDLSGNRL---TGSIPGFV--LPALSVLDLNQNLL-TGPVPPTLTSCGSLI 256 F + L L L+ NRL T G + LP ++ LDL+ N L +G + L SL Sbjct: 74 FQALTHLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSLH 133 Query: 257 KIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFST 316 + L+ N +T + + L LDL N L + +GL L L L N+ Sbjct: 134 TLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCI 193 Query: 317 TIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLN-SLRVLHLEGNNLTGEIPLEFRDVK 375 + L+ L +L LS +I+ S + L L L N L + + Sbjct: 194 SDF-----SLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLLHFP--DLAALP 246 Query: 376 HLSELRLNDNSLTGP-------------------VPFERDTVWRMRRKLRLYNNAGLCVN 416 L L L++N + P +P + R L N L N Sbjct: 247 RLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNASGRPLSQLLNLDLSYN 306 Query: 417 RDSDLDD--AFGSKSGSTVRLCDA 438 + D S + L Sbjct: 307 EIELIPDSFLEHLTSLCFLNLSRN 330 Score = 102 bits (253), Expect = 5e-22, Method: Composition-based stats. Identities = 82/364 (22%), Positives = 116/364 (31%), Gaps = 50/364 (13%) Query: 88 IECMPDQDNVYHVVSLSFGALSDDTAFPTCDPQRSYVSESLTRLKHLKALFFYRCLGRAP 147 IE L++ L ++ D L L L L L R P Sbjct: 211 IEAFQTASQPQAEFQLTWLDLRENKLLHFPD---------LAALPRLIYLNLSNNLIRLP 261 Query: 148 QRIPA-----------------------FLGRLGSSLQTLVLRENGFLGPIPDELGNLTN 184 P GR S L L L N L +LT+ Sbjct: 262 TGPPQDSKGIHAPSEGWSALPLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTS 321 Query: 185 LKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPGF-VLPALSVLDLNQNLLTG 243 L L+L +N L L LDLS N L G L +L L L N L Sbjct: 322 LCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNALETLELGARALGSLRTLLLQGNALRD 381 Query: 244 PVPPTLTSCGSLIKIDLSRNRVT-GPIPE--------SINRLNQLVLLDLSYNRLSGPFP 294 P T + SL +++L NRV+ P+ + + + L L L N + Sbjct: 382 LPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGITSLRSLSLVDNEIELLRA 441 Query: 295 SSLQGLNSLQALMLKGNTKFSTTIPENAFKGLK-NLMILVLSNTNIQGSIPKSLTRLNSL 353 + L L L N + A GL+ +L +L L + + L L Sbjct: 442 GAFLHTP-LTELDLSSNPG--LEVATGALGGLEASLEVLALQGNGLM-VLQVDLPCFICL 497 Query: 354 RVLHLEGNNLTGEIPLEFRDVKHLSELRLNDNSLTGPVPFERDTVWRMRRKLRLYNN-AG 412 + L+L N L+ + L L L +NS + + R+L L N Sbjct: 498 KRLNLAENRLSHLP--AWTQAVSLEVLDLRNNSFSLLPGSAMGGLETSLRRLYLQGNPLS 555 Query: 413 LCVN 416 C N Sbjct: 556 CCGN 559 >1XCD-A nrPDB Length = 329 Score = 149 bits (377), Expect = 2e-36, Method: Composition-based stats. Identities = 66/241 (27%), Positives = 101/241 (41%), Gaps = 33/241 (13%) Query: 175 IPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPGFVLP--ALS 232 +P +L T L LDL N + F L +L L N+++ PG P L Sbjct: 46 VPKDLPPDTAL--LDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLE 103 Query: 233 VLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRL--S 290 L L++N L P + +L ++ + N +T N LNQ+++++L N L S Sbjct: 104 RLYLSKNQLKEL-PEKMP--KTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSS 160 Query: 291 GPFPSSLQGL---------------------NSLQALMLKGNTKFSTTIPENAFKGLKNL 329 G + QG+ SL L L GN T + + KGL NL Sbjct: 161 GIENGAFQGMKKLSYIRIADTNITTIPQGLPPSLTELHLDGNK--ITKVDAASLKGLNNL 218 Query: 330 MILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLNDNSLTG 389 L LS +I SL LR LHL N L ++P D K++ + L++N+++ Sbjct: 219 AKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLV-KVPGGLADHKYIQVVYLHNNNISA 277 Query: 390 P 390 Sbjct: 278 I 278 Score = 112 bits (279), Expect = 4e-25, Method: Composition-based stats. Identities = 59/225 (26%), Positives = 96/225 (42%), Gaps = 26/225 (11%) Query: 207 SGLRSLDLSGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVT 266 LR + S L +P + P ++LDL N +T + +L + L N+++ Sbjct: 31 CHLRVVQCSDLGLEK-VPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKIS 89 Query: 267 GPIPESINRLNQLVLLDLSYNRLSGPF---------------------PSSLQGLNSLQA 305 P + L +L L LS N+L S GLN + Sbjct: 90 KISPGAFAPLVKLERLYLSKNQLKELPEKMPKTLQELRVHENEITKVRKSVFNGLNQMIV 149 Query: 306 LMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTG 365 + L N S+ I AF+G+K L + +++TNI +IP+ L SL LHL+GN +T Sbjct: 150 VELGTNPLKSSGIENGAFQGMKKLSYIRIADTNI-TTIPQGLP--PSLTELHLDGNKITK 206 Query: 366 EIPLEFRDVKHLSELRLNDNSLTGPVPFERDTVWRMRRKLRLYNN 410 + + +L++L L+ NS++ R+L L NN Sbjct: 207 VDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPH-LRELHLNNN 250 Score = 84.8 bits (208), Expect = 8e-17, Method: Composition-based stats. Identities = 46/227 (20%), Positives = 86/227 (37%), Gaps = 13/227 (5%) Query: 89 ECMPDQDNVYHVVSLSFGALSDDTAFPTCDPQRS-YVSESLTRLKHLKALFFYRC-LGRA 146 + + + F L + + + S + L L+ L+ + L Sbjct: 56 LLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQLKEL 115 Query: 147 PQRIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHL--NGSIPLSFN 204 P+++P +LQ L + EN L + V++L N L +G +F Sbjct: 116 PEKMP-------KTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQ 168 Query: 205 RFSGLRSLDLSGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNR 264 L + ++ +T +IP + P+L+ L L+ N +T +L +L K+ LS N Sbjct: 169 GMKKLSYIRIADTNIT-TIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNS 227 Query: 265 VTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGN 311 ++ S+ L L L+ N+L +Q + L N Sbjct: 228 ISAVDNGSLANTPHLRELHLNNNKLVKVPGGLADH-KYIQVVYLHNN 273 Score = 57.1 bits (136), Expect = 2e-08, Method: Composition-based stats. Identities = 28/126 (22%), Positives = 42/126 (33%), Gaps = 6/126 (4%) Query: 150 IPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGL 209 I + L + + + IP L +L L L N + S + L Sbjct: 162 IENGAFQGMKKLSYIRIADTNITT-IPQGLP--PSLTELHLDGNKITKVDAASLKGLNNL 218 Query: 210 RSLDLSGNRLTGSIPGFV--LPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTG 267 L LS N ++ G + P L L LN N L VP L + + L N ++ Sbjct: 219 AKLGLSFNSISAVDNGSLANTPHLRELHLNNNKL-VKVPGGLADHKYIQVVYLHNNNISA 277 Query: 268 PIPESI 273 Sbjct: 278 IGSNDF 283 >3B2D-A nrPDB Length = 603 Score = 149 bits (376), Expect = 2e-36, Method: Composition-based stats. Identities = 71/250 (28%), Positives = 100/250 (40%), Gaps = 12/250 (4%) Query: 148 QRIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFS 207 I + + + LQ L L G +P + L LK L L NH + +S F Sbjct: 264 SDISSTTFQCFTQLQELDLTATHLKG-LPSGMKGLNLLKKLVLSVNHFDQLCQISAANFP 322 Query: 208 GLRSLDLSGN--RLTGSIPG-FVLPALSVLDLNQNLLTGP--VPPTLTSCGSLIKIDLSR 262 L L + GN +L + L L LDL+ N + L + L ++LS Sbjct: 323 SLTHLYIRGNVKKLHLGVGCLEKLGNLQTLDLSHNDIEASDCCSLQLKNLSHLQTLNLSH 382 Query: 263 NRVTGPIPESINRLNQLVLLDLSYNRLSGPFPSS-LQGLNSLQALMLKGNTKFSTTIPEN 321 N G ++ QL LLDL++ RL P S Q L+ LQ L L F T ++ Sbjct: 383 NEPLGLQSQAFKECPQLELLDLAFTRLHINAPQSPFQNLHFLQVLNLTYC--FLDTSNQH 440 Query: 322 AFKGLKNLMILVLSNTNIQG---SIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLS 378 GL L L L + Q + L + SL VL L L F + +S Sbjct: 441 LLAGLPVLRHLNLKGNHFQDGTITKTNLLQTVGSLEVLILSSCGLLSIDQQAFHSLGKMS 500 Query: 379 ELRLNDNSLT 388 + L+ NSLT Sbjct: 501 HVDLSHNSLT 510 Score = 79.8 bits (195), Expect = 2e-15, Method: Composition-based stats. Identities = 49/188 (26%), Positives = 74/188 (39%), Gaps = 9/188 (4%) Query: 159 SSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLN-GSIPLSFNRFSGLRSLDLSGN 217 S LQTL L N LG L++LDL L+ + F L+ L+L+ Sbjct: 373 SHLQTLNLSHNEPLGLQSQAFKECPQLELLDLAFTRLHINAPQSPFQNLHFLQVLNLTYC 432 Query: 218 RLTGSIPGFV--LPALSVLDLNQNLL---TGPVPPTLTSCGSLIKIDLSRNRVTGPIPES 272 L S + LP L L+L N T L + GSL + LS + ++ Sbjct: 433 FLDTSNQHLLAGLPVLRHLNLKGNHFQDGTITKTNLLQTVGSLEVLILSSCGLLSIDQQA 492 Query: 273 INRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMIL 332 + L ++ +DLS+N L+ SL L + L L N+ I L + Sbjct: 493 FHSLGKMSHVDLSHNSLTCDSIDSLSHLKGI-YLNLAANSINI--ISPRLLPILSQQSTI 549 Query: 333 VLSNTNIQ 340 LS+ + Sbjct: 550 NLSHNPLD 557 Score = 77.5 bits (189), Expect = 1e-14, Method: Composition-based stats. Identities = 69/349 (19%), Positives = 114/349 (32%), Gaps = 45/349 (12%) Query: 127 SLTRLKHLKALFFYRCLGRAPQRIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLK 186 +L L+ L + + P+ P +L+ L + N +++ +L Sbjct: 124 NLENLESLYLGSNHISSIKFPKDFP------ARNLKVLDFQNNAIHYISREDMRSLEQAI 177 Query: 187 VLDLHKN--HLNGSIPLSFNR--FSGLRS-----LDLSGNRL------------------ 219 L L+ N ++ G +F+ F L L + N L Sbjct: 178 NLSLNFNGNNVKGIELGAFDSTIFQSLNFGGTPNLSVIFNGLQNSTTQSLWLGTFEDIDD 237 Query: 220 ----TGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINR 275 + + G ++ L+L ++ + T L ++DL+ + G P + Sbjct: 238 EDISSAMLKGLCEMSVESLNLQEHRFSDISSTTFQCFTQLQELDLTATHLKGL-PSGMKG 296 Query: 276 LNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLS 335 LN L L LS N S SL L ++GN K + L NL L LS Sbjct: 297 LNLLKKLVLSVNHFDQLCQISAANFPSLTHLYIRGNVKKLHLG-VGCLEKLGNLQTLDLS 355 Query: 336 NTNIQGSI--PKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLNDNSLTGPVPF 393 + +I+ S L L+ L+ L+L N G F++ L L L L P Sbjct: 356 HNDIEASDCCSLQLKNLSHLQTLNLSHNEPLGLQSQAFKECPQLELLDLAFTRLHINAPQ 415 Query: 394 ERDTVWRMRRKLRLYNNAGLCVNRDSDLDDAFGSKSGSTVRLCDAETSR 442 + L N C S+ G + L Sbjct: 416 SPFQNLHFLQVL----NLTYCFLDTSNQHLLAGLPVLRHLNLKGNHFQD 460 Score = 72.9 bits (177), Expect = 3e-13, Method: Composition-based stats. Identities = 58/301 (19%), Positives = 94/301 (31%), Gaps = 36/301 (11%) Query: 143 LGRAPQRIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLS 202 L P +P L S L N L NL LDL + +N + Sbjct: 21 LSEIPDTLPNTTEFLEFSFNFLPTIHN-------RTFSRLMNLTFLDLTRCQINWIHEDT 73 Query: 203 FNRFSGLRSLDLSGNRLTGSIPGFV--LPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDL 260 F L +L L+GN L + +L L L Q ++ + + +L + L Sbjct: 74 FQSHHQLSTLVLTGNPLIFMAETSLNGPKSLKHLFLIQTGISNLEFIPVHNLENLESLYL 133 Query: 261 SRNRVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPE 320 N ++ L +LD N + ++ L L L N I Sbjct: 134 GSNHISSIKFPKDFPARNLKVLDFQNNAIHYISREDMRSLEQAINLSLNFNGNNVKGIEL 193 Query: 321 NAF----------KGLKNLMIL--VLSNTNIQGSIPKSLTRLN---------------SL 353 AF G NL ++ L N+ Q + ++ S+ Sbjct: 194 GAFDSTIFQSLNFGGTPNLSVIFNGLQNSTTQSLWLGTFEDIDDEDISSAMLKGLCEMSV 253 Query: 354 RVLHLEGNNLTGEIPLEFRDVKHLSELRLNDNSLTGPVPFERDTVWRMRRKLRLYNNAGL 413 L+L+ + + F+ L EL L L G + + L + + L Sbjct: 254 ESLNLQEHRFSDISSTTFQCFTQLQELDLTATHLKGLPSGMKGLNLLKKLVLSVNHFDQL 313 Query: 414 C 414 C Sbjct: 314 C 314 Score = 67.9 bits (164), Expect = 1e-11, Method: Composition-based stats. Identities = 62/301 (20%), Positives = 97/301 (32%), Gaps = 61/301 (20%) Query: 158 GSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGN 217 SL+ L L + G + NL NL+ L L NH++ L+ LD N Sbjct: 101 PKSLKHLFLIQTGISNLEFIPVHNLENLESLYLGSNHISSIKFPKDFPARNLKVLDFQNN 160 Query: 218 RLTGSIPGFVLPALSVLDLN----QNLLTGPVPPTLTS----------CGSLIKI----- 258 + + ++L+ N + G S +L I Sbjct: 161 AIHYISREDMRSLEQAINLSLNFNGNNVKGIELGAFDSTIFQSLNFGGTPNLSVIFNGLQ 220 Query: 259 ------------------DLSRNRVTGPIPESINRLN------------------QLVLL 282 D+S + G S+ LN QL L Sbjct: 221 NSTTQSLWLGTFEDIDDEDISSAMLKGLCEMSVESLNLQEHRFSDISSTTFQCFTQLQEL 280 Query: 283 DLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFST-TIPENAFKGLKNLMILVLSNTNIQG 341 DL+ L G ++GLN L+ L+L N I F L +L I N Sbjct: 281 DLTATHLKGLPSG-MKGLNLLKKLVLSVNHFDQLCQISAANFPSLTHLYI--RGNVKKLH 337 Query: 342 SIPKSLTRLNSLRVLHLEGNNL--TGEIPLEFRDVKHLSELRLNDNSLTGPVPFERDTVW 399 L +L +L+ L L N++ + L+ +++ HL L L+ N G Sbjct: 338 LGVGCLEKLGNLQTLDLSHNDIEASDCCSLQLKNLSHLQTLNLSHNEPLGLQSQAFKECP 397 Query: 400 R 400 + Sbjct: 398 Q 398 >3CIG-A nrPDB Length = 697 Score = 145 bits (365), Expect = 5e-35, Method: Composition-based stats. Identities = 79/343 (23%), Positives = 130/343 (37%), Gaps = 51/343 (14%) Query: 54 TEPDEQDAVYDIMRATGNDWAAAIPDVCRGRWHGIECMPDQDNVYHVVSLSFGALSDDTA 113 T + D Y+ + GN + +P + R+ +E +N+ + SF LS+ Sbjct: 248 TNLTQLDLSYNNLHDVGNGSFSYLPSL---RYLSLE----YNNIQRLSPRSFYGLSNLRY 300 Query: 114 FPTCDPQRSYVSESLTRLKHLKALFFYRCLGRAPQRIPAFLGRLGSSLQTLVLRENGFLG 173 +R++ +S++ H I F + L+ L + +N Sbjct: 301 L---SLKRAFTKQSVSLASHPN--------------IDDFSFQWLKYLEYLNMDDNNIPS 343 Query: 174 PIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPGFVLPALSV 233 + L +LK L L K S + + L+ + L Sbjct: 344 TKSNTFTGLVSLKYLSLSKTF------TSLQTLTNETFVSLAHS------------PLLT 385 Query: 234 LDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRV-TGPIPESINRLNQLVLLDLSYNRLSGP 292 L+L +N ++ T + G L +DL N + + L + + LSYN+ Sbjct: 386 LNLTKNHISKIANGTFSWLGQLRILDLGLNEIEQKLSGQEWRGLRNIFEIYLSYNKYLQL 445 Query: 293 FPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNS 352 SS + SLQ LML+ + I + F+ L+NL IL LSN NI L L + Sbjct: 446 STSSFALVPSLQRLMLRRVALKNVDISPSPFRPLRNLTILDLSNNNIANINEDLLEGLEN 505 Query: 353 LRVLHLEGNNLTGEI-------PLEF-RDVKHLSELRLNDNSL 387 L +L + NNL P+ F + + HL L L N L Sbjct: 506 LEILDFQHNNLARLWKRANPGGPVNFLKGLSHLHILNLESNGL 548 Score = 127 bits (319), Expect = 1e-29, Method: Composition-based stats. Identities = 68/245 (27%), Positives = 99/245 (40%), Gaps = 8/245 (3%) Query: 172 LGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPGF--VLP 229 L IPD+L +N+ VL+L N L P +F R+S L LD N ++ P +LP Sbjct: 16 LTHIPDDLP--SNITVLNLTHNQLRRLPPTNFTRYSQLAILDAGFNSISKLEPELCQILP 73 Query: 230 ALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRL 289 L VL+L N L+ T C +L ++DL N + L+ LDLS+N L Sbjct: 74 LLKVLNLQHNELSQISDQTFVFCTNLTELDLMSNSIHKIKSNPFKNQKNLIKLDLSHNGL 133 Query: 290 SGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTR 349 S + L +LQ L+L N + E F G +L L LS+ ++ P Sbjct: 134 SSTKLGTGVQLENLQELLLAKNKILALRSEELEFLGNSSLRKLDLSSNPLKEFSPGCFQT 193 Query: 350 LNSLRVLHLEGNNLTGEIPLEFR---DVKHLSELRLNDNSLTGPVPFE-RDTVWRMRRKL 405 + L L L L + + + L L +N L W +L Sbjct: 194 IGKLFALLLNNAQLNPHLTEKLCWELSNTSIQNLSLANNQLLATSESTFSGLKWTNLTQL 253 Query: 406 RLYNN 410 L N Sbjct: 254 DLSYN 258 Score = 108 bits (270), Expect = 5e-24, Method: Composition-based stats. Identities = 72/306 (23%), Positives = 113/306 (36%), Gaps = 15/306 (4%) Query: 148 QRIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFS 207 +R+P S L L N P+ L LKVL+L N L+ +F + Sbjct: 38 RRLPPTNFTRYSQLAILDAGFNSISKLEPELCQILPLLKVLNLQHNELSQISDQTFVFCT 97 Query: 208 GLRSLDLSGNRLT--GSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRV 265 L LDL N + S P L LDL+ N L+ T +L ++ L++N++ Sbjct: 98 NLTELDLMSNSIHKIKSNPFKNQKNLIKLDLSHNGLSSTKLGTGVQLENLQELLLAKNKI 157 Query: 266 TGPIPESINRLNQ--LVLLDLSYNRLSGPFPSSLQGLNSLQALMLKG---NTKFSTTIPE 320 E + L L LDLS N L P Q + L AL+L N + + Sbjct: 158 LALRSEELEFLGNSSLRKLDLSSNPLKEFSPGCFQTIGKLFALLLNNAQLNPHLTEKLCW 217 Query: 321 NAFKGLKNLMILVLSNTNIQGSIPKSLTRL--NSLRVLHLEGNNLTGEIPLEFRDVKHLS 378 ++ L L+N + + + + L +L L L NNL F + L Sbjct: 218 EL--SNTSIQNLSLANNQLLATSESTFSGLKWTNLTQLDLSYNNLHDVGNGSFSYLPSLR 275 Query: 379 ELRLNDNSL--TGPVPFERDTVWRMRRKLRLYNNAGLCVNRDSDLDD--AFGSKSGSTVR 434 L L N++ P F + R R + + + ++DD K + Sbjct: 276 YLSLEYNNIQRLSPRSFYGLSNLRYLSLKRAFTKQSVSLASHPNIDDFSFQWLKYLEYLN 335 Query: 435 LCDAET 440 + D Sbjct: 336 MDDNNI 341 Score = 92.9 bits (229), Expect = 3e-19, Method: Composition-based stats. Identities = 73/323 (22%), Positives = 105/323 (32%), Gaps = 68/323 (21%) Query: 134 LKALFFYRCLGRAPQRIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKN 193 L L +I ++L L L N + N NL LDL N Sbjct: 72 LPLLKVLNLQHNELSQISDQTFVFCTNLTELDLMSNSIHKIKSNPFKNQKNLIKLDLSHN 131 Query: 194 HLNGSIPLS--------------------------FNRFSGLRSLDLSGNRLTGSIPGFV 227 L+ + + F S LR LDLS N L PG Sbjct: 132 GLSSTKLGTGVQLENLQELLLAKNKILALRSEELEFLGNSSLRKLDLSSNPLKEFSPGCF 191 Query: 228 L-----------------------------PALSVLDLNQNLLTGPVPPTLTSCG--SLI 256 ++ L L N L T + +L Sbjct: 192 QTIGKLFALLLNNAQLNPHLTEKLCWELSNTSIQNLSLANNQLLATSESTFSGLKWTNLT 251 Query: 257 KIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFST 316 ++DLS N + S + L L L L YN + P S GL++L+ L LK + Sbjct: 252 QLDLSYNNLHDVGNGSFSYLPSLRYLSLEYNNIQRLSPRSFYGLSNLRYLSLKRAFTKQS 311 Query: 317 T-------IPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLE--GNNLTGEI 367 I + +F+ LK L L + + NI + + T L SL+ L L +L Sbjct: 312 VSLASHPNIDDFSFQWLKYLEYLNMDDNNIPSTKSNTFTGLVSLKYLSLSKTFTSLQTLT 371 Query: 368 PLEFRDVKH--LSELRLNDNSLT 388 F + H L L L N ++ Sbjct: 372 NETFVSLAHSPLLTLNLTKNHIS 394 Score = 89.5 bits (220), Expect = 3e-18, Method: Composition-based stats. Identities = 70/319 (21%), Positives = 119/319 (37%), Gaps = 44/319 (13%) Query: 178 ELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPGFVL-----PALS 232 E ++L+ LDL N L P F L +L L+ +L + + ++ Sbjct: 166 EFLGNSSLRKLDLSSNPLKEFSPGCFQTIGKLFALLLNNAQLNPHLTEKLCWELSNTSIQ 225 Query: 233 VLDLNQNLLTGPVPPTLTSCG--SLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLS 290 L L N L T + +L ++DLS N + S + L L L L YN + Sbjct: 226 NLSLANNQLLATSESTFSGLKWTNLTQLDLSYNNLHDVGNGSFSYLPSLRYLSLEYNNIQ 285 Query: 291 GPFPSSLQGLNSLQALMLKGNTKFSTT-------IPENAFKGLKNLMILVLSNTNIQGSI 343 P S GL++L+ L LK + I + +F+ LK L L + + NI + Sbjct: 286 RLSPRSFYGLSNLRYLSLKRAFTKQSVSLASHPNIDDFSFQWLKYLEYLNMDDNNIPSTK 345 Query: 344 PKSLTRLNSLR----------------------------VLHLEGNNLTGEIPLEFRDVK 375 + T L SL+ L+L N+++ F + Sbjct: 346 SNTFTGLVSLKYLSLSKTFTSLQTLTNETFVSLAHSPLLTLNLTKNHISKIANGTFSWLG 405 Query: 376 HLSELRLNDNSLTGPVPFERDTVWRMRRKLRLYNNAGLCVNRDS-DLDDAFGSKSGSTVR 434 L L L N + + + R ++ L N L ++ S L + V Sbjct: 406 QLRILDLGLNEIEQKLSGQEWRGLRNIFEIYLSYNKYLQLSTSSFALVPSLQRLMLRRVA 465 Query: 435 LCDAETSRPAPSGTVQHLS 453 L + + S P+P +++L+ Sbjct: 466 LKNVDIS-PSPFRPLRNLT 483 >2V9T-B nrPDB Length = 220 Score = 142 bits (358), Expect = 3e-34, Method: Composition-based stats. Identities = 49/194 (25%), Positives = 88/194 (45%), Gaps = 4/194 (2%) Query: 212 LDLSGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPE 271 +D G LT IP + ++ + L QN + P + L +IDLS N+++ P+ Sbjct: 16 VDCRGKGLT-EIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPD 74 Query: 272 SINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMI 331 + L L L L N+++ S +GL SLQ L+L N + AF+ L NL + Sbjct: 75 AFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVD--AFQDLHNLNL 132 Query: 332 LVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEF-RDVKHLSELRLNDNSLTGP 390 L L + +Q + + L +++ +HL N + L++ D H + + + T P Sbjct: 133 LSLYDNKLQTIAKGTFSPLRAIQTMHLAQNPFICDCHLKWLADYLHTNPIETSGARCTSP 192 Query: 391 VPFERDTVWRMRRK 404 + +++ K Sbjct: 193 RRLANKRIGQIKSK 206 Score = 57.9 bits (138), Expect = 1e-08, Method: Composition-based stats. Identities = 27/129 (20%), Positives = 45/129 (34%), Gaps = 2/129 (1%) Query: 141 RCLGRAPQRIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIP 200 R + IP L+ + L N PD L +L L L+ N + Sbjct: 38 RLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPK 97 Query: 201 LSFNRFSGLRSLDLSGNRLTGSIPGFV--LPALSVLDLNQNLLTGPVPPTLTSCGSLIKI 258 F L+ L L+ N++ L L++L L N L T + ++ + Sbjct: 98 SLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTM 157 Query: 259 DLSRNRVTG 267 L++N Sbjct: 158 HLAQNPFIC 166 >4R6F-A nrPDB Length = 331 Score = 137 bits (346), Expect = 7e-33, Method: Composition-based stats. Identities = 68/247 (27%), Positives = 94/247 (38%), Gaps = 16/247 (6%) Query: 159 SSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNR 218 ++L L L N LTNL L+L N L F R + L +L+LS N Sbjct: 85 TNLGWLNLSNNQLETLPQGVFEKLTNLTTLNLSNNQLTSLPQGVFERLASLTTLNLSNNN 144 Query: 219 LTGSIPGFV--LPALSVLDLNQNLL--------TGPVPPTLTSCGSLIKIDLSRNRVTGP 268 + + L L+ L+L+ N L G L +L ++LS N Sbjct: 145 IANINDQMLEGLTNLTTLNLSHNNLARLWKHANPGGPIYFLKGLTNLTTLNLSSNGFDEI 204 Query: 269 IPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFST------TIPENA 322 E L L L+LS N ++ L+GL +L L L N P Sbjct: 205 PREVFKDLTSLTTLNLSNNNIANINDQMLEGLTNLTTLNLSHNNLARLWKHANPGGPIYF 264 Query: 323 FKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRL 382 KGL NL L LS+ + L SL L+L N LT F + +L L L Sbjct: 265 LKGLTNLTTLNLSSNGFDEIPREVFKDLTSLTTLNLSNNQLTSLPQGVFERLTNLKTLNL 324 Query: 383 NDNSLTG 389 ++N L Sbjct: 325 SNNQLQS 331 Score = 124 bits (311), Expect = 1e-28, Method: Composition-based stats. Identities = 61/257 (23%), Positives = 96/257 (37%), Gaps = 10/257 (3%) Query: 206 FSGLRSLDLSGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRV 265 +R L L GN+L L L L+L+ N L +L ++LS N++ Sbjct: 62 LPNVRYLALGGNKLHDISALKELTNLGWLNLSNNQLETLPQGVFEKLTNLTTLNLSNNQL 121 Query: 266 TGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTK------FSTTIP 319 T RL L L+LS N ++ L+GL +L L L N + P Sbjct: 122 TSLPQGVFERLASLTTLNLSNNNIANINDQMLEGLTNLTTLNLSHNNLARLWKHANPGGP 181 Query: 320 ENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSE 379 KGL NL L LS+ + L SL L+L NN+ + +L+ Sbjct: 182 IYFLKGLTNLTTLNLSSNGFDEIPREVFKDLTSLTTLNLSNNNIANINDQMLEGLTNLTT 241 Query: 380 LRLNDNSLTGPVPFERDTVW-RMRRKLRLYNNAGLCVNRDSDL--DDAFGSKSGSTVRLC 436 L L+ N+L + L L N ++ + S +T+ L Sbjct: 242 LNLSHNNLARLWKHANPGGPIYFLKGLTNLTTLNLSSNGFDEIPREVFKDLTSLTTLNLS 301 Query: 437 DAETSRPAPSGTVQHLS 453 + + + P G + L+ Sbjct: 302 NNQLTSL-PQGVFERLT 317 Score = 107 bits (268), Expect = 8e-24, Method: Composition-based stats. Identities = 64/292 (21%), Positives = 110/292 (37%), Gaps = 22/292 (7%) Query: 204 NRFSGLRSLDLSGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRN 263 N + + + + + + LP + L L N L L +L ++LS N Sbjct: 38 NELNSIDQIIANNSDIKSVQGIQYLPNVRYLALGGNKLHDIS--ALKELTNLGWLNLSNN 95 Query: 264 RVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAF 323 ++ +L L L+LS N+L+ + L SL L L N I + Sbjct: 96 QLETLPQGVFEKLTNLTTLNLSNNQLTSLPQGVFERLASLTTLNLSNN--NIANINDQML 153 Query: 324 KGLKNLMILVLSNTNIQ----GSIPKS----LTRLNSLRVLHLEGNNLTGEIPLEFRDVK 375 +GL NL L LS+ N+ + P L L +L L+L N F+D+ Sbjct: 154 EGLTNLTTLNLSHNNLARLWKHANPGGPIYFLKGLTNLTTLNLSSNGFDEIPREVFKDLT 213 Query: 376 HLSELRLNDNSLTGPVPFERDTVWRMRRKLRLYNNAGL---CVNRDSDLDDAFGSKSGST 432 L+ L L++N++ + + + +NN N + G + +T Sbjct: 214 SLTTLNLSNNNIANINDQMLEGLTNLTTLNLSHNNLARLWKHANPGGPIYFLKGLTNLTT 273 Query: 433 VRLCDA-------ETSRPAPSGTVQHLSREEDGALPDGATDVSSTSKSLGFS 477 + L E + S T +LS + +LP G + + K+L S Sbjct: 274 LNLSSNGFDEIPREVFKDLTSLTTLNLSNNQLTSLPQGVFERLTNLKTLNLS 325 Score = 97.5 bits (241), Expect = 1e-20, Method: Composition-based stats. Identities = 54/260 (20%), Positives = 92/260 (35%), Gaps = 24/260 (9%) Query: 74 AAAIPDVCRGRWHGIECMPDQDNVYHVVSLSFGALSDDTAFPTCDPQRSYVSESLTRLKH 133 +A+ ++ W + + + + F L++ T + Q + + + + Sbjct: 78 ISALKELTNLGWLNL----SNNQLETLPQGVFEKLTNLTTLNLSNNQLTSLPQGVFE--R 131 Query: 134 LKALFFYRCLGRAPQRIPAFLGRLGSSLQTLVLRENGFLGPIPDE--------LGNLTNL 185 L +L I + ++L TL L N L LTNL Sbjct: 132 LASLTTLNLSNNNIANINDQMLEGLTNLTTLNLSHNNLARLWKHANPGGPIYFLKGLTNL 191 Query: 186 KVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPGFV--LPALSVLDLNQNLL-- 241 L+L N + F + L +L+LS N + + L L+ L+L+ N L Sbjct: 192 TTLNLSSNGFDEIPREVFKDLTSLTTLNLSNNNIANINDQMLEGLTNLTTLNLSHNNLAR 251 Query: 242 ------TGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSGPFPS 295 G L +L ++LS N E L L L+LS N+L+ Sbjct: 252 LWKHANPGGPIYFLKGLTNLTTLNLSSNGFDEIPREVFKDLTSLTTLNLSNNQLTSLPQG 311 Query: 296 SLQGLNSLQALMLKGNTKFS 315 + L +L+ L L N S Sbjct: 312 VFERLTNLKTLNLSNNQLQS 331 >3A7C-A nrPDB Length = 580 Score = 136 bits (343), Expect = 2e-32, Method: Composition-based stats. Identities = 53/175 (30%), Positives = 79/175 (45%), Gaps = 6/175 (3%) Query: 217 NRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINRL 276 +R SIP + A+ LDL+ N +T L +C +L + L +R+ ++ L Sbjct: 40 SRSFTSIPSGLTAAMKSLDLSFNKITYIGHGDLRACANLQVLILKSSRINTIEGDAFYSL 99 Query: 277 NQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSN 336 L LDLS N LS S L+SL+ L L GN + T + F L NL L + N Sbjct: 100 GSLEHLDLSDNHLSSLSSSWFGPLSSLKYLNLMGN-PYQTLGVTSLFPNLTNLQTLRIGN 158 Query: 337 TNIQGSIPK----SLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLNDNSL 387 I + LT LN L + L N + RD+ HL+ L L++++ Sbjct: 159 VETFSEIRRIDFAGLTSLNELEIKALSLRNYQSQSLKSIRDIHHLT-LHLSESAF 212 Score = 74.4 bits (181), Expect = 1e-13, Method: Composition-based stats. Identities = 43/227 (18%), Positives = 76/227 (33%), Gaps = 43/227 (18%) Query: 150 IPAFLGRLGSSLQTLVLREN-GFLGPIPDELGN--LTNLKVLDLHKNHLNGSI--PLSFN 204 +P + SL+ L L EN + + +L+ L L +NHL Sbjct: 351 VPCSFSQHLKSLEFLDLSENLMVEEYLKNSACKGAWPSLQTLVLSQNHLRSMQKTGEILL 410 Query: 205 RFSGLRSLDLSGNRLTGSIPGFVLP-ALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRN 263 L SLD+S N P + L+L+ + +L +D+S N Sbjct: 411 TLKNLTSLDISRNTFHPMPDSCQWPEKMRFLNLSSTGIRVV---KTCIPQTLEVLDVSNN 467 Query: 264 RVTGPIPESIN-RLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENA 322 + +S + L +L L +S N+L +SL Sbjct: 468 NL-----DSFSLFLPRLQELYISRNKLKTLPDASL------------------------- 497 Query: 323 FKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPL 369 L+++ +++ ++ RL SL+ + L N P Sbjct: 498 ---FPVLLVMKIASNQLKSVPDGIFDRLTSLQKIWLHTNPWDCSCPR 541 Score = 72.5 bits (176), Expect = 4e-13, Method: Composition-based stats. Identities = 56/262 (21%), Positives = 96/262 (36%), Gaps = 14/262 (5%) Query: 148 QRIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFS 207 + + L +++++L L N +L NL+VL L + +N +F Sbjct: 41 RSFTSIPSGLTAAMKSLDLSFNKITYIGHGDLRACANLQVLILKSSRINTIEGDAFYSLG 100 Query: 208 GLRSLDLSGNRLTGSIPG--FVLPALSVLDLNQNLLTGP-VPPTLTSCGSLIKIDLSR-N 263 L LDLS N L+ L +L L+L N V + +L + + Sbjct: 101 SLEHLDLSDNHLSSLSSSWFGPLSSLKYLNLMGNPYQTLGVTSLFPNLTNLQTLRIGNVE 160 Query: 264 RVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLK-GNTKFSTTIPENA 322 + L L L++ L SL+ + + L L + F I + Sbjct: 161 TFSEIRRIDFAGLTSLNELEIKALSLRNYQSQSLKSIRDIHHLTLHLSESAFLLEIFADI 220 Query: 323 FKGLKNLMILVLSNTNIQGSIPKSLTRLNS-LRVLHLEGNNLTG----EIPLEFRDVKHL 377 ++ L L +N P + ++S ++ L G+ LT E+ R + L Sbjct: 221 LSSVRYLE-LRDTNLARFQFSPLPVDEVSSPMKKLAFRGSVLTDESFNELLKLLRYILEL 279 Query: 378 SELRLND---NSLTGPVPFERD 396 SE+ +D N L P E D Sbjct: 280 SEVEFDDCTLNGLGDFNPSESD 301 Score = 55.6 bits (132), Expect = 5e-08, Method: Composition-based stats. Identities = 42/193 (21%), Positives = 67/193 (34%), Gaps = 29/193 (15%) Query: 98 YHVVSLSFGALSDDTAFPTCDPQRSYVSESLTRLKHLKALFFYRCLGRAPQRIPAFLGRL 157 H+ SL F LS++ + S + L+ L + R+ Q+ L L Sbjct: 357 QHLKSLEFLDLSENLMVEEY-LKNSACKGA---WPSLQTLVLSQNHLRSMQKTGEILLTL 412 Query: 158 GSSLQTLVLRENGF-----LGPIPDELGNLT---------------NLKVLDLHKNHLNG 197 +L +L + N F P+++ L L+VLD+ N+L+ Sbjct: 413 -KNLTSLDISRNTFHPMPDSCQWPEKMRFLNLSSTGIRVVKTCIPQTLEVLDVSNNNLDS 471 Query: 198 SIPLSFNRFSGLRSLDLSGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIK 257 L+ L +S N+L + P L V+ + N L SL K Sbjct: 472 FSLF----LPRLQELYISRNKLKTLPDASLFPVLLVMKIASNQLKSVPDGIFDRLTSLQK 527 Query: 258 IDLSRNRVTGPIP 270 I L N P Sbjct: 528 IWLHTNPWDCSCP 540 Score = 51.7 bits (122), Expect = 6e-07, Method: Composition-based stats. Identities = 32/167 (19%), Positives = 53/167 (31%), Gaps = 9/167 (5%) Query: 294 PSSLQGLNS-----LQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLT 348 S + S +++L L N T I + NL +L+L ++ I + Sbjct: 40 SRSFTSIPSGLTAAMKSLDLSFNK--ITYIGHGDLRACANLQVLILKSSRINTIEGDAFY 97 Query: 349 RLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLNDNSLTGPVPFERDTVWRMRRKLRLY 408 L SL L L N+L+ F + L L L N + LR+ Sbjct: 98 SLGSLEHLDLSDNHLSSLSSSWFGPLSSLKYLNLMGNPYQTLGVTSLFPNLTNLQTLRIG 157 Query: 409 NNAGLCVNRDSDLDDAFGSKSG--STVRLCDAETSRPAPSGTVQHLS 453 N R D + L + ++ + HL+ Sbjct: 158 NVETFSEIRRIDFAGLTSLNELEIKALSLRNYQSQSLKSIRDIHHLT 204 >5D3I-A nrPDB Length = 568 Score = 135 bits (340), Expect = 4e-32, Method: Composition-based stats. Identities = 53/175 (30%), Positives = 79/175 (45%), Gaps = 6/175 (3%) Query: 217 NRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINRL 276 +R SIP + A+ LDL+ N +T L +C +L + L +R+ ++ L Sbjct: 18 SRSFTSIPSGLTAAMKSLDLSFNKITYIGHGDLRACANLQVLILKSSRINTIEGDAFYSL 77 Query: 277 NQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSN 336 L LDLS N LS S L+SL+ L L GN + T + F L NL L + N Sbjct: 78 GSLEHLDLSDNHLSSLSSSWFGPLSSLKYLNLMGN-PYQTLGVTSLFPNLTNLQTLRIGN 136 Query: 337 TNIQGSIPK----SLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLNDNSL 387 I + LT LN L + L N + RD+ HL+ L L++++ Sbjct: 137 VETFSEIRRIDFAGLTSLNELEIKALSLRNYQSQSLKSIRDIHHLT-LHLSESAF 190 Score = 71.7 bits (174), Expect = 7e-13, Method: Composition-based stats. Identities = 56/262 (21%), Positives = 96/262 (36%), Gaps = 14/262 (5%) Query: 148 QRIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFS 207 + + L +++++L L N +L NL+VL L + +N +F Sbjct: 19 RSFTSIPSGLTAAMKSLDLSFNKITYIGHGDLRACANLQVLILKSSRINTIEGDAFYSLG 78 Query: 208 GLRSLDLSGNRLTGSIPG--FVLPALSVLDLNQNLLTGP-VPPTLTSCGSLIKIDLSR-N 263 L LDLS N L+ L +L L+L N V + +L + + Sbjct: 79 SLEHLDLSDNHLSSLSSSWFGPLSSLKYLNLMGNPYQTLGVTSLFPNLTNLQTLRIGNVE 138 Query: 264 RVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLK-GNTKFSTTIPENA 322 + L L L++ L SL+ + + L L + F I + Sbjct: 139 TFSEIRRIDFAGLTSLNELEIKALSLRNYQSQSLKSIRDIHHLTLHLSESAFLLEIFADI 198 Query: 323 FKGLKNLMILVLSNTNIQGSIPKSLTRLNS-LRVLHLEGNNLTG----EIPLEFRDVKHL 377 ++ L L +N P + ++S ++ L G+ LT E+ R + L Sbjct: 199 LSSVRYLE-LRDTNLARFQFSPLPVDEVSSPMKKLAFRGSVLTDESFNELLKLLRYILEL 257 Query: 378 SELRLND---NSLTGPVPFERD 396 SE+ +D N L P E D Sbjct: 258 SEVEFDDCTLNGLGDFNPSESD 279 Score = 52.9 bits (125), Expect = 3e-07, Method: Composition-based stats. Identities = 65/385 (16%), Positives = 114/385 (29%), Gaps = 58/385 (15%) Query: 103 LSFGALSDDTAFPTCDPQ-RSYVSESLTRLKHLKALFFYRCLGRAPQRIPAFLGRLGSSL 161 + F L+ R+Y S+SL ++ + L + + + SS+ Sbjct: 146 IDFAGLTSLNELEIKALSLRNYQSQSLKSIRDIHHLTLHLSESAF---LLEIFADILSSV 202 Query: 162 QTLVLRENGFLGPIPDELG------NLTNLK-----VLDLHKNHLNGSIPLSFNRFSGLR 210 + L LR+ L + L + D N L + S + Sbjct: 203 RYLELRDTNLARFQFSPLPVDEVSSPMKKLAFRGSVLTDESFNELLKLLRYILE-LSEVE 261 Query: 211 SLDLSGNRLTGSIPGFV-----LPALSVLDLNQNLLT-----GPVPPTLTSCGSLIKIDL 260 D + N L P L + + + + + + + + +I + Sbjct: 262 FDDCTLNGLGDFNPSESDVVSELGKVETVTIRRLHIPQFYLFYDLSTVYSLLEKVKRITV 321 Query: 261 SRNRVTGPIPESINRLNQLVLLDLSYNRLSGPF---PSSLQGLNSLQALMLKGNTKFSTT 317 ++V L L LDLS N + + + SLQ L+L N S Sbjct: 322 ENSKVFLVPCSFSQHLKSLEFLDLSENLMVEEYLKNSACKGAWPSLQTLVLSQNHLRSMQ 381 Query: 318 IPENAFKGLKNLMILVLSNTNIQGSIPK-------SLTRLNS-------------LRVLH 357 LKNL L +S L+S L VL Sbjct: 382 KTGEILLTLKNLTSLDISRNTFHPMPDSCQWPEKMRFLNLSSTGIRVVKTCIPQTLEVLD 441 Query: 358 LEGNNLTGEIPLEFRDVKHLSELRLNDNSLTGPVPFERDTVWRMRRKLRLYNNA--GLCV 415 + NNL + L EL ++ N L V + +++ NA Sbjct: 442 VSNNNLDSFSL----FLPRLQELYISRNKLKTLPDASLFPVLLV---MKIRENAVSTFSK 494 Query: 416 NRDSDLDDAFGSKSGSTVRLCDAET 440 ++ ++G +C E Sbjct: 495 DQLGSFPKLETLEAGDNHFVCSCEL 519 Score = 51.3 bits (121), Expect = 9e-07, Method: Composition-based stats. Identities = 32/167 (19%), Positives = 53/167 (31%), Gaps = 9/167 (5%) Query: 294 PSSLQGLNS-----LQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLT 348 S + S +++L L N T I + NL +L+L ++ I + Sbjct: 18 SRSFTSIPSGLTAAMKSLDLSFNK--ITYIGHGDLRACANLQVLILKSSRINTIEGDAFY 75 Query: 349 RLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLNDNSLTGPVPFERDTVWRMRRKLRLY 408 L SL L L N+L+ F + L L L N + LR+ Sbjct: 76 SLGSLEHLDLSDNHLSSLSSSWFGPLSSLKYLNLMGNPYQTLGVTSLFPNLTNLQTLRIG 135 Query: 409 NNAGLCVNRDSDLDDAFGSKSG--STVRLCDAETSRPAPSGTVQHLS 453 N R D + L + ++ + HL+ Sbjct: 136 NVETFSEIRRIDFAGLTSLNELEIKALSLRNYQSQSLKSIRDIHHLT 182 Score = 51.3 bits (121), Expect = 1e-06, Method: Composition-based stats. Identities = 38/193 (19%), Positives = 68/193 (35%), Gaps = 29/193 (15%) Query: 98 YHVVSLSFGALSDDTAFPTCDPQRSYVSESLTRLKHLKALFFYRCLGRAPQRIPAFLGRL 157 H+ SL F LS++ + S + L+ L + R+ Q+ L L Sbjct: 335 QHLKSLEFLDLSENLMVEEY-LKNSACKGA---WPSLQTLVLSQNHLRSMQKTGEILLTL 390 Query: 158 GSSLQTLVLRENGF-----LGPIPDELGNLT---------------NLKVLDLHKNHLNG 197 +L +L + N F P+++ L L+VLD+ N+L+ Sbjct: 391 -KNLTSLDISRNTFHPMPDSCQWPEKMRFLNLSSTGIRVVKTCIPQTLEVLDVSNNNLDS 449 Query: 198 SIPLSFNRFSGLRSLDLSGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIK 257 L+ L +S N+L + P L V+ + +N ++ L S L Sbjct: 450 FSLF----LPRLQELYISRNKLKTLPDASLFPVLLVMKIRENAVSTFSKDQLGSFPKLET 505 Query: 258 IDLSRNRVTGPIP 270 ++ N Sbjct: 506 LEAGDNHFVCSCE 518 >2Z80-A nrPDB Length = 353 Score = 135 bits (340), Expect = 4e-32, Method: Composition-based stats. Identities = 50/163 (30%), Positives = 76/163 (46%), Gaps = 2/163 (1%) Query: 222 SIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVL 281 SIP + A+ LDL+ N +T L C +L + L+ N + +S + L L Sbjct: 45 SIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEH 104 Query: 282 LDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQG 341 LDLSYN LS S + L+SL L L GN + T + F L L IL + N + Sbjct: 105 LDLSYNYLSNLSSSWFKPLSSLTFLNLLGN-PYKTLGETSLFSHLTKLQILRVGNMDTFT 163 Query: 342 SI-PKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLN 383 I K L L L ++ ++L P + ++++S L L+ Sbjct: 164 KIQRKDFAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILH 206 Score = 77.9 bits (190), Expect = 1e-14, Method: Composition-based stats. Identities = 51/270 (18%), Positives = 91/270 (33%), Gaps = 33/270 (12%) Query: 149 RIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSG 208 + + L ++++L L N +L NL+ L L N +N SF+ Sbjct: 42 SLNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGS 101 Query: 209 LRSLDLSGNRLTGSIPGFV--LPALSVLDLNQNLLTGPVPPT-LTSCGSLIKIDLSR-NR 264 L LDLS N L+ + L +L+ L+L N + + L + + + Sbjct: 102 LEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMDT 161 Query: 265 VTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLK-GNTKFSTTIPENAF 323 T + L L L++ + L P SL+ + ++ L+L I + Sbjct: 162 FTKIQRKDFAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLEIFVDVT 221 Query: 324 KGLKNLMILV----------LSNTNIQGSIP------------------KSLTRLNSLRV 355 ++ L + LS I K L +++ L Sbjct: 222 SSVECLELRDTDLDTFHFSELSTGETNSLIKKFTFRNVKITDESLFQVMKLLNQISGLLE 281 Query: 356 LHLEGNNLTGEIPLEFRDVKHLSELRLNDN 385 L N L F + L ++ L+ N Sbjct: 282 LEFSRNQLKSVPDGIFDRLTSLQKIWLHTN 311 >2Z7X-A nrPDB Length = 549 Score = 135 bits (339), Expect = 5e-32, Method: Composition-based stats. Identities = 50/163 (30%), Positives = 76/163 (46%), Gaps = 2/163 (1%) Query: 222 SIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVL 281 SIP + A+ LDL+ N +T L C +L + L+ N + +S + L L Sbjct: 19 SIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEH 78 Query: 282 LDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQG 341 LDLSYN LS S + L+SL L L GN + T + F L L IL + N + Sbjct: 79 LDLSYNYLSNLSSSWFKPLSSLTFLNLLGN-PYKTLGETSLFSHLTKLQILRVGNMDTFT 137 Query: 342 SI-PKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLN 383 I K L L L ++ ++L P + ++++S L L+ Sbjct: 138 KIQRKDFAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILH 180 Score = 72.5 bits (176), Expect = 4e-13, Method: Composition-based stats. Identities = 41/206 (19%), Positives = 77/206 (37%), Gaps = 8/206 (3%) Query: 149 RIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSG 208 + + L ++++L L N +L NL+ L L N +N SF+ Sbjct: 16 SLNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGS 75 Query: 209 LRSLDLSGNRLTGSIPGFV--LPALSVLDLNQNLLTGPVPPT-LTSCGSLIKIDLSR-NR 264 L LDLS N L+ + L +L+ L+L N + + L + + + Sbjct: 76 LEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMDT 135 Query: 265 VTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFK 324 T + L L L++ + L P SL+ + ++ L+L + F Sbjct: 136 FTKIQRKDFAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILH---MKQHILLLEIFV 192 Query: 325 GLKNL-MILVLSNTNIQGSIPKSLTR 349 + + L L +T++ L+ Sbjct: 193 DVTSSVECLELRDTDLDTFHFSELST 218 Score = 65.2 bits (157), Expect = 6e-11, Method: Composition-based stats. Identities = 45/189 (23%), Positives = 68/189 (35%), Gaps = 29/189 (15%) Query: 205 RFSGLRSLDLSGN-----RLTGSIPGFVLPALSVLDLNQNLLTGPVP--PTLTSCGSLIK 257 L LDLS N L S P+L L L QN L TL + +L Sbjct: 332 HLKSLEYLDLSENLMVEEYLKNSACEDAWPSLQTLILRQNHLASLEKTGETLLTLKNLTN 391 Query: 258 IDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGL----------------- 300 ID+S+N PE+ ++ L+LS R+ + L Sbjct: 392 IDISKNSFHSM-PETCQWPEKMKYLNLSSTRIHSVTGCIPKTLEILDVSNNNLNLFSLNL 450 Query: 301 NSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEG 360 L+ L + N T+P+ + L L++L +S ++ RL SL+ + L Sbjct: 451 PQLKELYISRNK--LMTLPDASL--LPMLLVLKISRNQLKSVPDGIFDRLTSLQKIWLHT 506 Query: 361 NNLTGEIPL 369 N P Sbjct: 507 NPWDCSCPR 515 Score = 62.1 bits (149), Expect = 5e-10, Method: Composition-based stats. Identities = 47/228 (20%), Positives = 85/228 (37%), Gaps = 12/228 (5%) Query: 150 IPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGL 209 I + +LQ LVL NG D +L +L+ LDL N+L+ F S L Sbjct: 41 ISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWFKPLSSL 100 Query: 210 RSLDLSGN---RLTGSIPGFVLPALSVLDLNQ-NLLTGPVPPTLTSCGSLIKIDLSRNRV 265 L+L GN L + L L +L + + T L ++++ + + Sbjct: 101 TFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMDTFTKIQRKDFAGLTFLEELEIDASDL 160 Query: 266 TGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKG 325 P+S+ + + L L + + +S++ L L+ + G Sbjct: 161 QSYEPKSLKSIQNVSHLILHMKQHILLLEIFVDVTSSVECLELRDTDLDTFHFS-ELSTG 219 Query: 326 LKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRD 373 N +I + N++ + + L N ++G + LEF D Sbjct: 220 ETNSLIKKFTFRNVKITDESLFQVMKLL-------NQISGLLELEFDD 260 Score = 49.8 bits (117), Expect = 2e-06, Method: Composition-based stats. Identities = 40/182 (21%), Positives = 55/182 (30%), Gaps = 42/182 (23%) Query: 131 LKHLKALFFYRCLGRAPQRIPAFLGRLGSSLQTLVLRENGFLGP--IPDELGNLTNLKVL 188 LK L+ L L + SLQTL+LR+N + L L NL + Sbjct: 333 LKSLEYLDLSENLMVEEYLKNSACEDAWPSLQTLILRQNHLASLEKTGETLLTLKNLTNI 392 Query: 189 DLHKNHLNGSI----------------------------------------PLSFNRFSG 208 D+ KN + L Sbjct: 393 DISKNSFHSMPETCQWPEKMKYLNLSSTRIHSVTGCIPKTLEILDVSNNNLNLFSLNLPQ 452 Query: 209 LRSLDLSGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGP 268 L+ L +S N+L +LP L VL +++N L SL KI L N Sbjct: 453 LKELYISRNKLMTLPDASLLPMLLVLKISRNQLKSVPDGIFDRLTSLQKIWLHTNPWDCS 512 Query: 269 IP 270 P Sbjct: 513 CP 514 Score = 44.4 bits (103), Expect = 1e-04, Method: Composition-based stats. Identities = 39/211 (18%), Positives = 71/211 (33%), Gaps = 28/211 (13%) Query: 227 VLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGP---IPESINRLNQLVLLD 283 + + + + + + SL +DLS N + + L L Sbjct: 308 LTERVKRITVENSKVFLVPCLLSQHLKSLEYLDLSENLMVEEYLKNSACEDAWPSLQTLI 367 Query: 284 LSYNRLSGPFPS--SLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQG 341 L N L+ + +L L +L + + N+ S + + + L LS+T I Sbjct: 368 LRQNHLASLEKTGETLLTLKNLTNIDISKNSFHSM---PETCQWPEKMKYLNLSSTRIHS 424 Query: 342 S---IPKSLTRL--------------NSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLND 384 IPK+L L L+ L++ N L + L L+++ Sbjct: 425 VTGCIPKTLEILDVSNNNLNLFSLNLPQLKELYISRNKLMTLPDASL--LPMLLVLKISR 482 Query: 385 NSLTGPVPFERDTVWRMRRKLRLYNNAGLCV 415 N L D + +K+ L+ N C Sbjct: 483 NQLKSVPDGIFDRL-TSLQKIWLHTNPWDCS 512 >4QDH-A nrPDB Length = 438 Score = 131 bits (330), Expect = 5e-31, Method: Composition-based stats. Identities = 80/322 (24%), Positives = 117/322 (36%), Gaps = 22/322 (6%) Query: 109 SDDTAFPTCDPQRSYVSESLTRLKH-----LKALFFYRCLGRAPQRIPAFLGRLGSSLQT 163 S T P+ + S L L H L L I + S LQ Sbjct: 28 SVPTGIPSSATRLELESNKLQSLPHGVFDKLTQLTKLSLSRNNLVTIKPEMFVNLSRLQC 87 Query: 164 LVLRENGFLGPIP-DELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTGS 222 L L N + + LTNL+VLDL N L+ SF+ L++LDLS N S Sbjct: 88 LSLSHNSIAQAVNGSQFLPLTNLQVLDLSHNKLDLYHWKSFSELPQLQALDLSYNSQPFS 147 Query: 223 IPGF--------VLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPES-- 272 + G L L L L N + V L S S+ +D S N + E Sbjct: 148 MKGIGHNFSFVTHLSMLQSLSLAHNDIHTRVSSHLNS-NSVRFLDFSGNGMGRMWDEGGL 206 Query: 273 ----INRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKN 328 L+ L+ LDLS N L P +L L L+ + + + L N Sbjct: 207 YLHFFQGLSGLLKLDLSQNNLHILRPQNLDNLPKSLKLLSLR-DNYLSFFNWTSLSFLPN 265 Query: 329 LMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLNDNSLT 388 L +L L+ ++ +L L+ L + N++ +P F L E+ L+ N L Sbjct: 266 LEVLDLAGNQLKALTNGTLPNGTLLQKLDVSSNSIVSVVPAFFALAVELKEVNLSHNILK 325 Query: 389 GPVPFERDTVWRMRRKLRLYNN 410 + ++L L N Sbjct: 326 TVDRSWFGPIVMNLKELALDTN 347 Score = 104 bits (259), Expect = 1e-22, Method: Composition-based stats. Identities = 49/195 (25%), Positives = 74/195 (37%), Gaps = 32/195 (16%) Query: 210 RSLDLSGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPI 269 + + LT S+P + + + L+L N L L K+ LSRN + Sbjct: 17 TEIRCNSKGLT-SVPTGIPSSATRLELESNKLQSLPHGVFDKLTQLTKLSLSRNNLVTIK 75 Query: 270 PESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNL 329 PE L++L L LS+N ++ Q +N Q L L NL Sbjct: 76 PEMFVNLSRLQCLSLSHNSIA-------QAVNGSQFL------------------PLTNL 110 Query: 330 MILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNL---TGEIPLEFRDVKHLSELR---LN 383 +L LS+ + KS + L L+ L L N+ I F V HLS L+ L Sbjct: 111 QVLDLSHNKLDLYHWKSFSELPQLQALDLSYNSQPFSMKGIGHNFSFVTHLSMLQSLSLA 170 Query: 384 DNSLTGPVPFERDTV 398 N + V ++ Sbjct: 171 HNDIHTRVSSHLNSN 185 Score = 69.0 bits (167), Expect = 4e-12, Method: Composition-based stats. Identities = 56/271 (20%), Positives = 77/271 (28%), Gaps = 63/271 (23%) Query: 100 VVSLSFGALSDDTAFPTCDPQRSYVSESLTRLKHLKALFFYRCLGRAPQRIPAFLGRLGS 159 + +L LS + D L +L+ L + + S Sbjct: 107 LTNLQVLDLSHNKL----DLYHWKSFSELPQLQALDLSYNSQPFSMKGIGHNFSFVTHLS 162 Query: 160 SLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNG------SIPLSFNRFSGLRSLD 213 LQ+L L N + L + +++ LD N + F SGL LD Sbjct: 163 MLQSLSLAHNDIHTRVSSHLNS-NSVRFLDFSGNGMGRMWDEGGLYLHFFQGLSGLLKLD 221 Query: 214 LSGNRLTGSIPGFV---------------------------LPALSVLDLNQNLLTGPVP 246 LS N L P + LP L VLDL N L Sbjct: 222 LSQNNLHILRPQNLDNLPKSLKLLSLRDNYLSFFNWTSLSFLPNLEVLDLAGNQLKALTN 281 Query: 247 PTLTSCGSLIKID------------------------LSRNRVTGPIPESINR-LNQLVL 281 TL + L K+D LS N + + L Sbjct: 282 GTLPNGTLLQKLDVSSNSIVSVVPAFFALAVELKEVNLSHNILKTVDRSWFGPIVMNLKE 341 Query: 282 LDLSYNRLSGPFPSSLQGLNSLQALMLKGNT 312 L L N+L L SLQ + L N Sbjct: 342 LALDTNQLKSVPDGIFDRLTSLQKIWLHTNP 372 >3J0A-A nrPDB Length = 844 Score = 129 bits (324), Expect = 2e-30, Method: Composition-based stats. Identities = 77/314 (24%), Positives = 114/314 (36%), Gaps = 54/314 (17%) Query: 153 FLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSL 212 F G SS++ L L L +LKVL+L N +N +F L+ L Sbjct: 260 FAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVL 319 Query: 213 DLSGNRLTGSIPGFV--LPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGP-- 268 +LS N L LP ++ +DL +N + T L +DL N +T Sbjct: 320 NLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHF 379 Query: 269 ---IPESINRLNQLVLL----------DLSYNRLSGPFPSSLQ-GLNSLQALMLKGNTKF 314 IP+ N+LV L LS NRL + LQ L+L N Sbjct: 380 IPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFS 439 Query: 315 STTIP----------------------------ENAFKGLKNLMILVLSNTNIQGSIPKS 346 S + + F+GL +L +L L++ + P Sbjct: 440 SCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGV 499 Query: 347 LTRLNSLRVLHLEGNNLTGEIPLEFRDV-KHLSELRLNDNSLTGPVPFERDTVWRMRRKL 405 + L +LR L L N LT L D+ +L L ++ N L P P V+ L Sbjct: 500 FSHLTALRGLSLNSNRLT---VLSHNDLPANLEILDISRNQLLAPNP----DVFVSLSVL 552 Query: 406 RLYNNAGLCVNRDS 419 + +N +C S Sbjct: 553 DITHNKFICECELS 566 Score = 114 bits (284), Expect = 1e-25, Method: Composition-based stats. Identities = 67/230 (29%), Positives = 96/230 (41%), Gaps = 44/230 (19%) Query: 128 LTRLKHLKAL-----FFYRCLG-RAPQRIPAFLGRLGSSLQTLVLRENGFLGPIPDELG- 180 L R+ HL+ L F C G + P P SL+ L L EN EL Sbjct: 422 LLRVPHLQILILNQNRFSSCSGDQTPSENP--------SLEQLFLGENMLQLAWETELCW 473 Query: 181 ----NLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPGFVLPALSVLDL 236 L++L+VL L+ N+LN P F+ + LR L L+ NRLT + L +LD+ Sbjct: 474 DVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEILDI 533 Query: 237 NQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPES--INRLNQLVLLDLSYNRLSGPF- 293 ++N L P P S L D++ N+ S IN LN + ++GP Sbjct: 534 SRNQLLAPNPDVFVSLSVL---DITHNKFICECELSTFINWLNHTNV------TIAGPPA 584 Query: 294 ------PSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNT 337 P S G+ SL +L +G E K LK + +V + T Sbjct: 585 DIYCVYPDSFSGV-SLFSLSTEGCD------EEEVLKSLKFSLFIVCTVT 627 Score = 92.5 bits (228), Expect = 4e-19, Method: Composition-based stats. Identities = 57/350 (16%), Positives = 98/350 (28%), Gaps = 75/350 (21%) Query: 142 CLGRAPQRIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNL--TNLKVLDLHKNHLNGSI 199 A + AF L + + P + L ++++ LDL + Sbjct: 223 NFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLN 282 Query: 200 PLSFNRFSGLRSLDLSGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKID 259 F L VL+L N + +L ++ Sbjct: 283 SRVFETLKDL----------------------KVLNLAYNKINKIADEAFYGLDNLQVLN 320 Query: 260 LSRNRVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIP 319 LS N + + L ++ +DL N ++ + + L LQ L L+ N + Sbjct: 321 LSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFI 380 Query: 320 EN---AFKGLKNLMIL----------VLSNTNIQGSIPKSL-TRLNSLRVLHLEGNNLT- 364 + F L+ L LS ++ R+ L++L L N + Sbjct: 381 PSIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSS 440 Query: 365 ---GEIPLE--------------------------FRDVKHLSELRLNDNSLTGPVPFER 395 + P E F + HL L LN N L P Sbjct: 441 CSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPP--- 497 Query: 396 DTVWRMRRKLRLYNNAGLCVNRDSDLDDAFGSKSGSTVRLCDAETSRPAP 445 + L L NR + L + + + + P P Sbjct: 498 ----GVFSHLTALRGLSLNSNRLTVLSHNDLPANLEILDISRNQLLAPNP 543 Score = 82.1 bits (201), Expect = 4e-16, Method: Composition-based stats. Identities = 67/341 (19%), Positives = 110/341 (32%), Gaps = 62/341 (18%) Query: 113 AFPTCDPQRSYVSESLTRLKHLKALFFY---RCLGRAPQRIPAFLGRLGSSLQTLVLREN 169 + C+ + V + L + L F Y P L LGS L + + Sbjct: 10 FYRFCNLTQ--VPQVLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKE 67 Query: 170 GFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPGF--- 226 NL NL++LDL + + P +F L L L L+ ++ Sbjct: 68 --------AFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYF 119 Query: 227 -VLPALSVLDLNQNLLTG-PVPPTLTSCGSLIKIDLSRNRVTGPIPESINRL--NQLVLL 282 L AL+ LDL++N + + P+ SL ID S N++ + L L Sbjct: 120 RNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFF 179 Query: 283 DLSYNRLSGPFPSSLQGLNS------LQALMLKGNT------------------------ 312 L+ N L + L+ L + GN Sbjct: 180 SLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILA 239 Query: 313 ----------KFSTTIPENAFKGL--KNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEG 360 +N F GL ++ L LS+ + + L L+VL+L Sbjct: 240 HHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAY 299 Query: 361 NNLTGEIPLEFRDVKHLSELRLNDNSLTGPVPFERDTVWRM 401 N + F + +L L L+ N L + ++ Sbjct: 300 NKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKV 340 Score = 76.0 bits (185), Expect = 3e-14, Method: Composition-based stats. Identities = 47/192 (24%), Positives = 71/192 (36%), Gaps = 16/192 (8%) Query: 202 SFNRFSGLRSLDLSGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDL- 260 +F RF L + VL L L+ N + + L ++L Sbjct: 9 AFYRFCNLTQV------------PQVLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELG 56 Query: 261 SRNRVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPE 320 S+ E+ L L +LDL +++ P + QGL L L L + + Sbjct: 57 SQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKD 116 Query: 321 NAFKGLKNLMILVLSNTNIQG-SIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRDV--KHL 377 F+ LK L L LS I+ + S +LNSL+ + N + E + K L Sbjct: 117 GYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTL 176 Query: 378 SELRLNDNSLTG 389 S L NSL Sbjct: 177 SFFSLAANSLYS 188 >3RG1-A nrPDB Length = 612 Score = 126 bits (315), Expect = 3e-29, Method: Composition-based stats. Identities = 64/251 (25%), Positives = 104/251 (41%), Gaps = 12/251 (4%) Query: 148 QRIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFS 207 + + R + +Q L L G +P + + +LK L L+ N + ++ F Sbjct: 266 SDLSSSTFRCFTRVQELDLTAAHLNG-LPSGIEGMNSLKKLVLNANSFDQLCQINAASFP 324 Query: 208 GLRSLDLSGNRLTGSIPG---FVLPALSVLDLNQNLLTGP--VPPTLTSCGSLIKIDLSR 262 LR L + GN + L L LDL+ + + L + L ++LS Sbjct: 325 SLRDLYIKGNMRKLDLGTRCLEKLENLQKLDLSHSDIEASDCCNLQLKNLRHLQYLNLSY 384 Query: 263 NRVTGPIPESINRLNQLVLLDLSYNRLSGPFPSS-LQGLNSLQALMLKGNTKFSTTIPEN 321 N G ++ QL LLD+++ L P S Q L+ L+ L L T ++ Sbjct: 385 NEPLGLEDQAFKECPQLELLDVAFTHLHVKAPHSPFQNLHLLRVLNLSHC--LLDTSNQH 442 Query: 322 AFKGLKNLMILVLSNTNIQG---SIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLS 378 GL++L L L + Q S L + SL +L L NL F +++++ Sbjct: 443 LLAGLQDLRHLNLQGNSFQDGSISKTNLLQMVGSLEILILSSCNLLSIDQQAFHGLRNVN 502 Query: 379 ELRLNDNSLTG 389 L L+ NSLTG Sbjct: 503 HLDLSHNSLTG 513 Score = 83.3 bits (204), Expect = 2e-16, Method: Composition-based stats. Identities = 52/187 (27%), Positives = 74/187 (39%), Gaps = 9/187 (4%) Query: 160 SLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLS-FNRFSGLRSLDLSGNR 218 LQ L L N LG L++LD+ HL+ P S F LR L+LS Sbjct: 376 HLQYLNLSYNEPLGLEDQAFKECPQLELLDVAFTHLHVKAPHSPFQNLHLLRVLNLSHCL 435 Query: 219 LTGSIPGFV--LPALSVLDLNQNLL---TGPVPPTLTSCGSLIKIDLSRNRVTGPIPESI 273 L S + L L L+L N + L GSL + LS + ++ Sbjct: 436 LDTSNQHLLAGLQDLRHLNLQGNSFQDGSISKTNLLQMVGSLEILILSSCNLLSIDQQAF 495 Query: 274 NRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILV 333 + L + LDLS+N L+G +L L L L + N IP + L I+ Sbjct: 496 HGLRNVNHLDLSHNSLTGDSMDALSHLKGL-YLNMASN--NIRIIPPHLLPALSQQSIIN 552 Query: 334 LSNTNIQ 340 LS+ + Sbjct: 553 LSHNPLD 559 Score = 76.7 bits (187), Expect = 2e-14, Method: Composition-based stats. Identities = 75/365 (20%), Positives = 119/365 (32%), Gaps = 62/365 (16%) Query: 110 DDTAFPTCDPQRSYVSESLTRLKHLKALFFYRCLGRAPQRIPAFLGRLGSSLQTLVLREN 169 +T T +P SLT K LK LF + + IP +L++L L N Sbjct: 82 LNTIVLTGNPLIFMAETSLTGPKFLKHLFLTQTGISNLEFIP---VHNLENLESLHLGSN 138 Query: 170 GFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLR--SLDLSGNRLTGSIPGFV 227 E NLKVLD N ++ N SL+ +GN + G PG Sbjct: 139 HISSINLPENFPTQNLKVLDFQNNAIHYISRKDTNSLEQATNLSLNFNGNDIKGIEPGAF 198 Query: 228 LPA-----------------------------------------------------LSVL 234 + + + Sbjct: 199 ISKIFQSLKFGGSLNLFIIFKGLQNSTLQSLWLGTFEDTDDQYLTSATFEGLCDMSVESI 258 Query: 235 DLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSGPFP 294 +L ++ + T + ++DL+ + G P I +N L L L+ N Sbjct: 259 NLQKHRFSDLSSSTFRCFTRVQELDLTAAHLNGL-PSGIEGMNSLKKLVLNANSFDQLCQ 317 Query: 295 SSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSI--PKSLTRLNS 352 + SL+ L +KGN + + L+NL L LS+++I+ S L L Sbjct: 318 INAASFPSLRDLYIKGNMRKLDLG-TRCLEKLENLQKLDLSHSDIEASDCCNLQLKNLRH 376 Query: 353 LRVLHLEGNNLTGEIPLEFRDVKHLSELRLNDNSLTGPVPFERDTVWRMRRKLRLYNNAG 412 L+ L+L N G F++ L L + L P + R L L + Sbjct: 377 LQYLNLSYNEPLGLEDQAFKECPQLELLDVAFTHLHVKAPHSPFQNLHLLRVLNLSHCLL 436 Query: 413 LCVNR 417 N+ Sbjct: 437 DTSNQ 441 Score = 69.4 bits (168), Expect = 3e-12, Method: Composition-based stats. Identities = 54/283 (19%), Positives = 87/283 (30%), Gaps = 32/283 (11%) Query: 138 FFYRCLGRAPQRIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNG 197 Y C + IP L ++ + L N L NL LDL + +N Sbjct: 14 RTYNCENLGLREIPDT---LPNTTEVLEFSFNFLPTIQNTTFSRLINLIFLDLTRCQINW 70 Query: 198 SIPLSFNRFSGLRSLDLSGNRLTGSIPGFVLPA--LSVLDLNQNLLTGPVPPTLTSCGSL 255 +F L ++ L+GN L + L L L Q ++ + + +L Sbjct: 71 VHEDTFQSHHQLNTIVLTGNPLIFMAETSLTGPKFLKHLFLTQTGISNLEFIPVHNLENL 130 Query: 256 IKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFS 315 + L N ++ L +LD N + L L L N Sbjct: 131 ESLHLGSNHISSINLPENFPTQNLKVLDFQNNAIHYISRKDTNSLEQATNLSLNFNGNDI 190 Query: 316 TTIPENA--------------------FKGLKNLMILVLSNTNIQGSIPKSLTRLN---- 351 I A FKGL+N + L + + + LT Sbjct: 191 KGIEPGAFISKIFQSLKFGGSLNLFIIFKGLQNSTLQSLWLGTFEDTDDQYLTSATFEGL 250 Query: 352 ---SLRVLHLEGNNLTGEIPLEFRDVKHLSELRLNDNSLTGPV 391 S+ ++L+ + + FR + EL L L G Sbjct: 251 CDMSVESINLQKHRFSDLSSSTFRCFTRVQELDLTAAHLNGLP 293 Score = 68.3 bits (165), Expect = 8e-12, Method: Composition-based stats. Identities = 56/266 (21%), Positives = 97/266 (36%), Gaps = 33/266 (12%) Query: 153 FLGRLGSSLQTLVLR------ENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRF 206 F G S+LQ+L L + + L +++ ++ ++L K+ + +F F Sbjct: 218 FKGLQNSTLQSLWLGTFEDTDDQYLTSATFEGLCDMS-VESINLQKHRFSDLSSSTFRCF 276 Query: 207 SGLRSLDLSGNRLTGSIPG-FVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRV 265 + ++ LDL+ L G G + +L L LN N S SL + + N Sbjct: 277 TRVQELDLTAAHLNGLPSGIEGMNSLKKLVLNANSFDQLCQINAASFPSLRDLYIKGN-- 334 Query: 266 TGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKG 325 + LDL L + L +LQ L L + ++ K Sbjct: 335 -------------MRKLDLGTRCL--------EKLENLQKLDLSHSDIEASDCCNLQLKN 373 Query: 326 LKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLE-FRDVKHLSELRLND 384 L++L L LS G ++ L +L + +L + P F+++ L L L+ Sbjct: 374 LRHLQYLNLSYNEPLGLEDQAFKECPQLELLDVAFTHLHVKAPHSPFQNLHLLRVLNLSH 433 Query: 385 NSLTGPVPFERDTVWRMRRKLRLYNN 410 L + R L L N Sbjct: 434 CLLDTSN-QHLLAGLQDLRHLNLQGN 458 Score = 48.6 bits (114), Expect = 6e-06, Method: Composition-based stats. Identities = 40/180 (22%), Positives = 67/180 (37%), Gaps = 18/180 (10%) Query: 117 CDPQRSYVSESLTRLKHLKALFFYRCLGRAPQRIPAFLGRLGSSLQTLVLRENGFLGPIP 176 D ++ L L+HL G + L ++ SL+ L+L L Sbjct: 436 LDTSNQHLLAGLQDLRHLNLQGNSFQDGSISKTN---LLQMVGSLEILILSSCNLLSIDQ 492 Query: 177 DELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPGFVLPAL---SV 233 L N+ LDL N L G + + GL L+++ N + IP +LPAL S+ Sbjct: 493 QAFHGLRNVNHLDLSHNSLTGDSMDALSHLKGL-YLNMASNNI-RIIPPHLLPALSQQSI 550 Query: 234 LDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINRL---NQLVLLDLSYNRLS 290 ++L+ N L +C ++ I + + L + LS +L Sbjct: 551 INLSHNPLD-------CTCSNIHFITWYKENLHKLEDSEETTCANPPSLRGVKLSDVKLH 603 >3T6Q-A nrPDB Length = 606 Score = 125 bits (314), Expect = 4e-29, Method: Composition-based stats. Identities = 65/249 (26%), Positives = 92/249 (36%), Gaps = 12/249 (4%) Query: 150 IPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGL 209 I + S LQ L L +P L L+ LK L L N +S + F L Sbjct: 269 ISSNTFHCFSGLQELDLTATHLSE-LPSGLVGLSTLKKLVLSANKFENLCQISASNFPSL 327 Query: 210 RSLDLSGNRLTGSIPGFVLPALS---VLDLNQNLLTGP--VPPTLTSCGSLIKIDLSRNR 264 L + GN + L L LDL+ + + L + L ++LS N Sbjct: 328 THLSIKGNTKRLELGTGCLENLENLRELDLSHDDIETSDCCNLQLRNLSHLQSLNLSYNE 387 Query: 265 VTGPIPESINRLNQLVLLDLSYNRLS-GPFPSSLQGLNSLQALMLKGNTKFSTTIPENAF 323 E+ QL LLDL++ RL S Q L+ L+ L L E F Sbjct: 388 PLSLKTEAFKECPQLELLDLAFTRLKVKDAQSPFQNLHLLKVLNLSH--SLLDISSEQLF 445 Query: 324 KGLKNLMILVLSNTNIQGSI---PKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSEL 380 GL L L L + SL L L +L L +L+ F +K ++ + Sbjct: 446 DGLPALQHLNLQGNHFPKGNIQKTNSLQTLGRLEILVLSFCDLSSIDQHAFTSLKMMNHV 505 Query: 381 RLNDNSLTG 389 L+ N LT Sbjct: 506 DLSHNRLTS 514 Score = 77.5 bits (189), Expect = 1e-14, Method: Composition-based stats. Identities = 86/473 (18%), Positives = 144/473 (30%), Gaps = 82/473 (17%) Query: 57 DEQDAVYDIMRATGNDWAAAIPDVCRGRWHGIECMPDQDNV--YHVVSLSFGALS----- 109 E + Y+ N+ +P+ +P N +++L+F L+ Sbjct: 11 KEVNKTYNCENLGLNEIPGTLPNSTECLEFSFNVLPTIQNTTFSRLINLTFLDLTRCQIY 70 Query: 110 ------------DDTAFPTCDPQRSYVSESLTRLKHLKALFFYRCLGRAPQRIPAFLGRL 157 DT T +P +L+ K LK LFF + I Sbjct: 71 WIHEDTFQSQHRLDTLVLTANPLIFMAETALSGPKALKHLFF---IQTGISSIDFIPLHN 127 Query: 158 GSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLR--SLDLS 215 +L++L L N + LKVLD N ++ + SL+L+ Sbjct: 128 QKTLESLYLGSNHISSIKLPKGFPTEKLKVLDFQNNAIHYLSKEDMSSLQQATNLSLNLN 187 Query: 216 GNRLTGSIPGFVLPAL-------------------------------------------- 231 GN + G PG A+ Sbjct: 188 GNDIAGIEPGAFDSAVFQSLNFGGTQNLLVIFKGLKNSTIQSLWLGTFEDMDDEDISPAV 247 Query: 232 ---------SVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLL 282 ++L ++ T L ++DL+ ++ P + L+ L L Sbjct: 248 FEGLCEMSVESINLQKHYFFNISSNTFHCFSGLQELDLTATHLSEL-PSGLVGLSTLKKL 306 Query: 283 DLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGS 342 LS N+ S SL L +KGNTK + L+NL L LS+ +I+ S Sbjct: 307 VLSANKFENLCQISASNFPSLTHLSIKGNTKRLELG-TGCLENLENLRELDLSHDDIETS 365 Query: 343 I--PKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLNDNSLTGPVPFERDTVWR 400 L L+ L+ L+L N F++ L L L L Sbjct: 366 DCCNLQLRNLSHLQSLNLSYNEPLSLKTEAFKECPQLELLDLAFTRLKVKDAQSPFQNLH 425 Query: 401 MRRKLRLYNN-AGLCVNRDSDLDDAFGSKSGSTVRLCDAETSRPAPSGTVQHL 452 + + L L ++ + + D A + + T+ L Sbjct: 426 LLKVLNLSHSLLDISSEQLFDGLPALQHLNLQGNHFPKGNIQKTNSLQTLGRL 478 Score = 73.3 bits (178), Expect = 3e-13, Method: Composition-based stats. Identities = 55/247 (22%), Positives = 89/247 (36%), Gaps = 36/247 (14%) Query: 159 SSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLN-GSIPLSFNRFSGLRSLDLSGN 217 S LQ+L L N L + L++LDL L F L+ L+LS + Sbjct: 376 SHLQSLNLSYNEPLSLKTEAFKECPQLELLDLAFTRLKVKDAQSPFQNLHLLKVLNLSHS 435 Query: 218 RLTGSIPGFV--LPALSVLDLNQNLLTGPV---PPTLTSCGSLIKIDLSRNRVTGPIPES 272 L S LPAL L+L N +L + G L + LS ++ + Sbjct: 436 LLDISSEQLFDGLPALQHLNLQGNHFPKGNIQKTNSLQTLGRLEILVLSFCDLSSIDQHA 495 Query: 273 INRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMIL 332 L + +DLS+NRL+ +L L + L Sbjct: 496 FTSLKMMNHVDLSHNRLTSSSIEALSHLKGI---------------------------YL 528 Query: 333 VLSNTNIQGSIPKSLTRLNSLRVLHLEGNNL---TGEIPLEFRDVKHLSELRLNDNSLTG 389 L++ +I +P L L+ R ++L N L I +++ +L +++L Sbjct: 529 NLASNHISIILPSLLPILSQQRTINLRQNPLDCTCSNIYFLEWYKENMQKLEDTEDTLCE 588 Query: 390 PVPFERD 396 P R Sbjct: 589 NPPLLRG 595 Score = 63.3 bits (152), Expect = 3e-10, Method: Composition-based stats. Identities = 44/228 (19%), Positives = 77/228 (33%), Gaps = 10/228 (4%) Query: 77 IPDVCRGRWHGIECMPDQDNVYH-VVSLSFGALSDDTAFPTCDP--QRSYVSESLTRLKH 133 D C + + + + Y+ +SL A + D R V ++ + ++ Sbjct: 364 TSDCCNLQLRNLSHLQSLNLSYNEPLSLKTEAFKECPQLELLDLAFTRLKVKDAQSPFQN 423 Query: 134 LKALFFYRCLGRAPQRIPAFLGRLGSSLQTLVLRENGFLG---PIPDELGNLTNLKVLDL 190 L L L +LQ L L+ N F + L L L++L L Sbjct: 424 LHLLKVLNLSHSLLDISSEQLFDGLPALQHLNLQGNHFPKGNIQKTNSLQTLGRLEILVL 483 Query: 191 HKNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPGFVLP-ALSVLDLNQNLLTGPVPPTL 249 L+ +F + +DLS NRLT S + L+L N ++ +P L Sbjct: 484 SFCDLSSIDQHAFTSLKMMNHVDLSHNRLTSSSIEALSHLKGIYLNLASNHISIILPSLL 543 Query: 250 TSCGSLIKIDLSRNRVTGPIPESIN---RLNQLVLLDLSYNRLSGPFP 294 I+L +N + + L+ + + L P Sbjct: 544 PILSQQRTINLRQNPLDCTCSNIYFLEWYKENMQKLEDTEDTLCENPP 591 >5YQ5-A nrPDB Length = 430 Score = 124 bits (311), Expect = 9e-29, Method: Composition-based stats. Identities = 49/219 (22%), Positives = 86/219 (39%), Gaps = 18/219 (8%) Query: 128 LTRLKHLKALFFYRCLGRAPQRIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLKV 187 +L +L L + F L SL+ L+L N + + L NL + Sbjct: 135 FAKLPNLLQLHLEHN------NLEEFPFPLPKSLERLLLGYNEISKLQTNAMDGLVNLTM 188 Query: 188 LDLHKNHLNG--SIPLSFNRFSGLRSLDLSGNRLTGSIPGFVLPALSVLDLNQNLLTGPV 245 LDL N+L+ F + L L+L NRL S+P + +L L L N ++ Sbjct: 189 LDLCYNYLHDSLLKDKIFAKMEKLMQLNLCSNRL-ESMPPGLPSSLMYLSLENNSISSIP 247 Query: 246 PPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQA 305 L + +S N++ P +I L +V L + +N+L + +L+ Sbjct: 248 EKYFDKLPKLHTLRMSHNKLQDI-PYNIFNLPNIVELSVGHNKLK----QAFYIPRNLEH 302 Query: 306 LMLKGN--TKFSTTIPENAFKGLKN--LMILVLSNTNIQ 340 L L+ N K + T+ + L L + + ++ Sbjct: 303 LYLQNNEIEKMNLTVMCPSIDPLHYHHLTYIRVDQNKLK 341 Score = 116 bits (291), Expect = 2e-26, Method: Composition-based stats. Identities = 54/235 (22%), Positives = 92/235 (39%), Gaps = 15/235 (6%) Query: 157 LGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNG--SIPLSFNRFSGLRSLDL 214 + +Q L L+ N + N T+LK ++L N + F + L L L Sbjct: 87 IPMHIQQLYLQFNEIEAVTANSFINATHLKEINLSHNKIKSQKIDYGVFAKLPNLLQLHL 146 Query: 215 SGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTG--PIPES 272 N L + +L L L N ++ + +L +DL N + + Sbjct: 147 EHNNLEEFPFP-LPKSLERLLLGYNEISKLQTNAMDGLVNLTMLDLCYNYLHDSLLKDKI 205 Query: 273 INRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMIL 332 ++ +L+ L+L NRL P +SL L L+ N+ ++IPE F L L L Sbjct: 206 FAKMEKLMQLNLCSNRLESMPP---GLPSSLMYLSLENNS--ISSIPEKYFDKLPKLHTL 260 Query: 333 VLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLNDNSL 387 +S+ +Q L ++ L + N L F ++L L L +N + Sbjct: 261 RMSHNKLQDIPYNIF-NLPNIVELSVGHNKLK----QAFYIPRNLEHLYLQNNEI 310 Score = 90.2 bits (222), Expect = 2e-18, Method: Composition-based stats. Identities = 45/227 (19%), Positives = 86/227 (37%), Gaps = 28/227 (12%) Query: 184 NLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPGFVLPALSVLDLNQNLLTG 243 +++ L L N + SF + L+ ++LS N++ Sbjct: 90 HIQQLYLQFNEIEAVTANSFINATHLKEINLSHNKIKS--------------------QK 129 Query: 244 PVPPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSL 303 +L+++ L N + L L L YN +S +++ GL +L Sbjct: 130 IDYGVFAKLPNLLQLHLEHNNLEEFP---FPLPKSLERLLLGYNEISKLQTNAMDGLVNL 186 Query: 304 QALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNL 363 L L N + + + F ++ LM L L + ++ P + SL L LE N++ Sbjct: 187 TMLDLCYNYLHDSLLKDKIFAKMEKLMQLNLCSNRLESMPPGLPS---SLMYLSLENNSI 243 Query: 364 TGEIPLEFRDVKHLSELRLNDNSLTGPVPFERDTVWRMRRKLRLYNN 410 + F + L LR++ N L P+ + + +L + +N Sbjct: 244 SSIPEKYFDKLPKLHTLRMSHNKLQDI-PYNIFNLPNIV-ELSVGHN 288 Score = 74.4 bits (181), Expect = 1e-13, Method: Composition-based stats. Identities = 39/194 (20%), Positives = 68/194 (35%), Gaps = 17/194 (8%) Query: 254 SLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSG--PFPSSLQGLNSLQALMLKGN 311 + ++ L N + S L ++LS+N++ L +L L L+ N Sbjct: 90 HIQQLYLQFNEIEAVTANSFINATHLKEINLSHNKIKSQKIDYGVFAKLPNLLQLHLEHN 149 Query: 312 TKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLE- 370 + E F K+L L+L I ++ L +L +L L N L + + Sbjct: 150 N-----LEEFPFPLPKSLERLLLGYNEISKLQTNAMDGLVNLTMLDLCYNYLHDSLLKDK 204 Query: 371 -FRDVKHLSELRLNDNSLTGPVPFERDTVWRMRRKLRLYNNAGLCVNRDSDLDDAFGSKS 429 F ++ L +L L N L P + L L NN + + D Sbjct: 205 IFAKMEKLMQLNLCSNRLESMPP----GLPSSLMYLSLENN-SISSIPEKYFDKL---PK 256 Query: 430 GSTVRLCDAETSRP 443 T+R+ + Sbjct: 257 LHTLRMSHNKLQDI 270 Score = 69.0 bits (167), Expect = 4e-12, Method: Composition-based stats. Identities = 35/189 (18%), Positives = 61/189 (32%), Gaps = 12/189 (6%) Query: 94 QDNVYHVVSLSFGALSDDTAFPTCDPQRSYVSESLTRLKHLKALFFYRCLGRAPQRIPAF 153 + + + + + L + T C +Y+ +SL + K + L R+ + Sbjct: 169 YNEISKLQTNAMDGLVNLTMLDLC---YNYLHDSLLKDKIFAKMEKLMQLNLCSNRLESM 225 Query: 154 LGRLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLD 213 L SSL L L N L L L + N L F + L Sbjct: 226 PPGLPSSLMYLSLENNSISSIPEKYFDKLPKLHTLRMSHNKLQDIPYNIF-NLPNIVELS 284 Query: 214 LSGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLT------SCGSLIKIDLSRNRVTG 267 + N+L + ++ L L L N + + L I + +N++ Sbjct: 285 VGHNKLKQAF--YIPRNLEHLYLQNNEIEKMNLTVMCPSIDPLHYHHLTYIRVDQNKLKE 342 Query: 268 PIPESINRL 276 PI I Sbjct: 343 PISSYIFFC 351 >2FT3-A nrPDB Length = 332 Score = 121 bits (304), Expect = 6e-28, Method: Composition-based stats. Identities = 60/248 (24%), Positives = 100/248 (40%), Gaps = 17/248 (6%) Query: 143 LGRAPQRIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLS 202 L P+ I L L+ N D+ L +L L L N ++ + Sbjct: 45 LKAVPKEISPDTTL-------LDLQNNDISELRKDDFKGLQHLYALVLVNNKISKIHEKA 97 Query: 203 FNRFSGLRSLDLSGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSR 262 F+ L+ L +S N L IP + +L L ++ N + + ++ I++ Sbjct: 98 FSPLRKLQKLYISKNHL-VEIPPNLPSSLVELRIHDNRIRKVPKGVFSGLRNMNCIEMGG 156 Query: 263 NRV--TGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPE 320 N + +G P + + L +L L +S +L+G + LN L L N I Sbjct: 157 NPLENSGFEPGAFDGL-KLNYLRISEAKLTGIPKDLPETLN---ELHLDHNK--IQAIEL 210 Query: 321 NAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSEL 380 L L L + I+ SL+ L +LR LHL+ N L +P D+K L + Sbjct: 211 EDLLRYSKLYRLGLGHNQIRMIENGSLSFLPTLRELHLDNNKL-SRVPAGLPDLKLLQVV 269 Query: 381 RLNDNSLT 388 L+ N++T Sbjct: 270 YLHTNNIT 277 Score = 93.7 bits (231), Expect = 2e-19, Method: Composition-based stats. Identities = 58/270 (21%), Positives = 107/270 (39%), Gaps = 29/270 (10%) Query: 194 HLNGSIPLS-----FNRFSGLRSLDLSGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPT 248 L+ P F LR + S L ++P + P ++LDL N ++ Sbjct: 15 DLDSLPPTYSAMCPFGCHCHLRVVQCSDLGL-KAVPKEISPDTTLLDLQNNDISELRKDD 73 Query: 249 LTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALML 308 L + L N+++ ++ + L +L L +S N L P+ SL L + Sbjct: 74 FKGLQHLYALVLVNNKISKIHEKAFSPLRKLQKLYISKNHLVEIPPNLPS---SLVELRI 130 Query: 309 KGNTKFSTTIPENAFKGLKNLMILVLSNTNIQG--SIPKSLTRLNSLRVLHLEGNNLTGE 366 N +P+ F GL+N+ + + ++ P + L L L + LTG Sbjct: 131 HDNR--IRKVPKGVFSGLRNMNCIEMGGNPLENSGFEPGAFDGLK-LNYLRISEAKLTGI 187 Query: 367 IPLEFRDV-KHLSELRLNDNSLTGPVPFERDTVWRMRRKLRLYNNAGLCVNRDSDLDD-- 423 +D+ + L+EL L+ N + E + + R + RL GL N+ +++ Sbjct: 188 P----KDLPETLNELHLDHNKIQAI---ELEDLLRYSKLYRL----GLGHNQIRMIENGS 236 Query: 424 AFGSKSGSTVRLCDAETSR-PAPSGTVQHL 452 + + L + + SR PA ++ L Sbjct: 237 LSFLPTLRELHLDNNKLSRVPAGLPDLKLL 266 Score = 85.6 bits (210), Expect = 4e-17, Method: Composition-based stats. Identities = 51/224 (22%), Positives = 88/224 (39%), Gaps = 12/224 (5%) Query: 132 KHLKALFFYRCLGRAPQRIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLH 191 K L+ L+ + +I LQ L + +N + IP L ++L L +H Sbjct: 75 KGLQHLYALVLVNNKISKIHEKAFSPLRKLQKLYISKNHLVE-IPPNLP--SSLVELRIH 131 Query: 192 KNHLNGSIPLSFNRFSGLRSLDLSGNRL--TGSIPGFVLP-ALSVLDLNQNLLTGPVPPT 248 N + F+ + +++ GN L +G PG L+ L +++ LTG P Sbjct: 132 DNRIRKVPKGVFSGLRNMNCIEMGGNPLENSGFEPGAFDGLKLNYLRISEAKLTGI-PKD 190 Query: 249 LTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALML 308 L +L ++ L N++ E + R ++L L L +N++ SL L +L+ L L Sbjct: 191 LP--ETLNELHLDHNKIQAIELEDLLRYSKLYRLGLGHNQIRMIENGSLSFLPTLRELHL 248 Query: 309 KGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNS 352 N LK L ++ L NI + Sbjct: 249 DNNKLSRV---PAGLPDLKLLQVVYLHTNNITKVGVNDFCPVGF 289 >2XOT-A nrPDB Length = 361 Score = 118 bits (295), Expect = 6e-27, Method: Composition-based stats. Identities = 59/193 (30%), Positives = 76/193 (39%), Gaps = 13/193 (6%) Query: 140 YRCLGRAPQRIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSI 199 + L PQ +P++ L S L R P LTNL L L NHLN Sbjct: 27 KQQLPNVPQSLPSYTALLDLSHNNLS-RLRAEWTPT-----RLTNLHSLLLSHNHLNFIS 80 Query: 200 PLSFNRFSGLRSLDLSGNRLTG--SIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIK 257 +F LR LDLS N L L AL VL L N + L K Sbjct: 81 SEAFVPVPNLRYLDLSSNHLHTLDEFLFSDLQALEVLLLYNNHIVVVDRNAFEDMAQLQK 140 Query: 258 IDLSRNRVTGPIPESI---NRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQA--LMLKGNT 312 + LS+N+++ E I N+L +L+LLDLS N+L + LQ L + L L N Sbjct: 141 LYLSQNQISRFPVELIKDGNKLPKLMLLDLSSNKLKKLPLTDLQKLPAWVKNGLYLHNNP 200 Query: 313 KFSTTIPENAFKG 325 F Sbjct: 201 LECDCKLYQLFSH 213 Score = 85.6 bits (210), Expect = 5e-17, Method: Composition-based stats. Identities = 43/176 (24%), Positives = 68/176 (38%), Gaps = 12/176 (6%) Query: 200 PLSFNRFSGLRSLDLSGNRLTGSIPGFVLPALS---VLDLNQNLLTGPVPPTLTSCGSLI 256 P S ++ L LDLS N L+ + L+ L L+ N L +L Sbjct: 34 PQSLPSYTAL--LDLSHNNLSRLRAEWTPTRLTNLHSLLLSHNHLNFISSEAFVPVPNLR 91 Query: 257 KIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFST 316 +DLS N + + L L +L L N + ++ + + LQ L L N + Sbjct: 92 YLDLSSNHLHTLDEFLFSDLQALEVLLLYNNHIVVVDRNAFEDMAQLQKLYLSQNQ--IS 149 Query: 317 TIPENAFKG---LKNLMILVLSNTNIQGSIPKSLTRLNSL--RVLHLEGNNLTGEI 367 P K L LM+L LS+ ++ L +L + L+L N L + Sbjct: 150 RFPVELIKDGNKLPKLMLLDLSSNKLKKLPLTDLQKLPAWVKNGLYLHNNPLECDC 205 Score = 81.4 bits (199), Expect = 7e-16, Method: Composition-based stats. Identities = 46/191 (24%), Positives = 74/191 (38%), Gaps = 15/191 (7%) Query: 206 FSGLRSLDLSGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTS-CGSLIKIDLSRNR 264 L S +L +P + ++LDL+ N L+ + +L + LS N Sbjct: 17 LCASNILSCSKQQLPN-VPQSLPSYTALLDLSHNNLSRLRAEWTPTRLTNLHSLLLSHNH 75 Query: 265 VTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFK 324 + E+ + L LDLS N L L +L+ L+L N + NAF+ Sbjct: 76 LNFISSEAFVPVPNLRYLDLSSNHLHTLDEFLFSDLQALEVLLLYNN--HIVVVDRNAFE 133 Query: 325 GLKNLMILVLSNTNIQGSIPKSLT---RLNSLRVLHLEGNNLTGEIPLEFRDVKHL---- 377 + L L LS I + + +L L +L L N L D++ L Sbjct: 134 DMAQLQKLYLSQNQISRFPVELIKDGNKLPKLMLLDLSSNKLKKLP---LTDLQKLPAWV 190 Query: 378 -SELRLNDNSL 387 + L L++N L Sbjct: 191 KNGLYLHNNPL 201 Score = 75.2 bits (183), Expect = 6e-14, Method: Composition-based stats. Identities = 53/209 (25%), Positives = 81/209 (38%), Gaps = 34/209 (16%) Query: 214 LSGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPE-S 272 L+ R S P L A ++L ++ L VP +L S +L +DLS N ++ E + Sbjct: 3 LASGRSVVSCPANCLCASNILSCSKQQLPN-VPQSLPSYTAL--LDLSHNNLSRLRAEWT 59 Query: 273 INRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMIL 332 RL L L LS+N L+ AF + NL L Sbjct: 60 PTRLTNLHSLLLSHNHLNFISS--------------------------EAFVPVPNLRYL 93 Query: 333 VLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLNDNSLTGPVP 392 LS+ ++ + L +L VL L N++ F D+ L +L L+ N ++ P Sbjct: 94 DLSSNHLHTLDEFLFSDLQALEVLLLYNNHIVVVDRNAFEDMAQLQKLYLSQNQIS-RFP 152 Query: 393 FERDTVWRMRRKLRLYNNAGLCVNRDSDL 421 E KL L + L N+ L Sbjct: 153 VELIKDGNKLPKLMLLD---LSSNKLKKL 178 Score = 55.6 bits (132), Expect = 5e-08, Method: Composition-based stats. Identities = 29/142 (20%), Positives = 54/142 (38%), Gaps = 12/142 (8%) Query: 109 SDDTAFPTCDPQRSYVSESLTRLKHLKALFFYRCLGRAPQRIPAFLGRLGSSLQTLVLRE 168 + + + + SE+ + +L+ L + FL +L+ L+L Sbjct: 65 NLHSLLLSHNHLNFISSEAFVPVPNLRYLDLSSNHLHT---LDEFLFSDLQALEVLLLYN 121 Query: 169 NGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSF---NRFSGLRSLDLSGNRLTGSIPG 225 N + + ++ L+ L L +N ++ N+ L LDLS N+L +P Sbjct: 122 NHIVVVDRNAFEDMAQLQKLYLSQNQISRFPVELIKDGNKLPKLMLLDLSSNKLKK-LPL 180 Query: 226 FVLPAL-----SVLDLNQNLLT 242 L L + L L+ N L Sbjct: 181 TDLQKLPAWVKNGLYLHNNPLE 202 >4R08-A nrPDB Length = 811 Score = 115 bits (287), Expect = 6e-26, Method: Composition-based stats. Identities = 64/277 (23%), Positives = 91/277 (32%), Gaps = 20/277 (7%) Query: 163 TLVLRENGFLGPI-PDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGN---- 217 L L N + E + ++K LDL N L+ + S L LDLS N Sbjct: 487 CLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYF 546 Query: 218 RLTGSIPGFVL----PALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPES- 272 R+ G L VL+L+ N + SL+++ S NR+ + Sbjct: 547 RIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLESKSLVELVFSGNRLDILWNDDD 606 Query: 273 ------INRLNQLVLLDLSYNRLSGPFPSSLQGLN-SLQALMLKGNTKFSTTIPENAFKG 325 L L LDLS NRL + L SL L + N + Sbjct: 607 NRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDN--MLKFFNWTLLQQ 664 Query: 326 LKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLNDN 385 L +L L + +SLR L L N ++ +V L L L+ N Sbjct: 665 FPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSN 724 Query: 386 SLTGPVPFERDTVWRM-RRKLRLYNNAGLCVNRDSDL 421 L +T L L+ N C D Sbjct: 725 LLKTINKSALETKTTTKLSMLELHGNPFECTCDIGDF 761 Score = 99.9 bits (247), Expect = 2e-21, Method: Composition-based stats. Identities = 84/419 (20%), Positives = 135/419 (32%), Gaps = 82/419 (19%) Query: 52 ARTEP-DEQDAVYDIMRATGNDWAAAIPDVCRGRWHGIECMPDQDNVYHVVSLSFGALSD 110 +R+ P DE+ ++ N +P + E + + H+ + SF L + Sbjct: 9 SRSYPCDEKKQNDSVIAECSNRRLQEVPQTVGK--YVTELDLSDNFITHITNESFQGLQN 66 Query: 111 DTAF-----PTCDPQR----------SYVSESLTRLKHLKALFFYRCLGRAPQRIPAFLG 155 T P Q + + LK+L+ L ++P Sbjct: 67 LTKINLNHNPNVQHQNGNPGIQSNGLNITDGAFLNLKNLRELLLEDN------QLPQIPS 120 Query: 156 RLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKN-------HLNGSIPLSFNRFSG 208 L SL L L +N + + L NLK L L N F + Sbjct: 121 GLPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWNCYFNKVCEKTNIEDGVFETLTN 180 Query: 209 LRSLDLSGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGP 268 L L LS N L+ P + +L L L+ + +L +DLS N Sbjct: 181 LELLSLSFNSLSHVPPK-LPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCF 239 Query: 269 IPE-----------------SINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGN 311 + L QL L+LS L + + + L+ L L+ N Sbjct: 240 NAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFN 299 Query: 312 TKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPK------SLTRLNSLRVLHLEG----- 360 L L IL LS I+GS P+ + ++L SLR LHL G Sbjct: 300 YLVGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQE 359 Query: 361 ----------------------NNLTGEIPLEFRDVKHLSELRLNDNSLTGPVPFERDT 397 N + F++ +L + L++N ++ V R + Sbjct: 360 LREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQS 418 Score = 84.5 bits (207), Expect = 1e-16, Method: Composition-based stats. Identities = 54/236 (22%), Positives = 88/236 (37%), Gaps = 14/236 (5%) Query: 157 LGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSG 216 L SSL+ L L ++ L NL +LDL N P FN D Sbjct: 198 LPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGN-----CPRCFNAPFPCVPCDGGA 252 Query: 217 NRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPES--IN 274 + L L L+L+ L + L +DL N + G I + Sbjct: 253 SINIDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLT 312 Query: 275 RLNQLVLLDLSYNRLSGPFP------SSLQGLNSLQALMLKG-NTKFSTTIPENAFKGLK 327 L +L +LDLS+N + G +P + L SL+AL L+G + L Sbjct: 313 MLPRLEILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQPLMQLP 372 Query: 328 NLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLN 383 NL + L I+ K ++L +++L N ++ + + + S + + Sbjct: 373 NLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYANSSSFQRH 428 Score = 82.1 bits (201), Expect = 5e-16, Method: Composition-based stats. Identities = 56/295 (18%), Positives = 95/295 (32%), Gaps = 20/295 (6%) Query: 60 DAVYDIMRATGNDWAAAIPDVCRGRWHGIECMPDQDNVYHVVSLSFGALSDDTAFPTCDP 119 D + + G + +PD+ + N + F A+ + Sbjct: 465 DLSLNSIFFIGPNQFENLPDIA------CLNLSANSNAQVLSGTEFSAIPHVKYLDLTNN 518 Query: 120 QRSYVSES----LTRLKHLKALFFYRCLGRAPQRIPAFLGRLGSSLQTLVLRENGFLGPI 175 + + + S L+ L+ L + A + ++L+ L L N Sbjct: 519 RLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLT 578 Query: 176 PDELGNLTNLKVLDLHKNHLNGS-------IPLSFNRFSGLRSLDLSGNRLTGSIPG--- 225 +L L N L+ F L LDLS NRL Sbjct: 579 DKYNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFL 638 Query: 226 FVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLLDLS 285 + +L+ L +N N+L L L +DL N++ + + L L LS Sbjct: 639 NLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLS 698 Query: 286 YNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQ 340 +NR+S L ++SL+ L L N + K L +L L + Sbjct: 699 HNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPFE 753 >5ZSN-B nrPDB Length = 823 Score = 113 bits (283), Expect = 2e-25, Method: Composition-based stats. Identities = 66/284 (23%), Positives = 104/284 (36%), Gaps = 21/284 (7%) Query: 150 IPAFLGRLGSSLQTLVLRENGFLGPIP-DELGNLTNLKVLDLHKNHLNGSIPLSFNRFSG 208 I + + S L+ L L N + E L L+ LD N L+ +F Sbjct: 486 IKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLLHSTAFEELRK 545 Query: 209 LRSLDLSGNR---LTGSIPGFV-----LPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDL 260 L LD+S N + I + L L L +N N ++ T+ S SL ++ Sbjct: 546 LEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSSTSRTMES-ESLRTLEF 604 Query: 261 SRNRVTGPIPES-------INRLNQLVLLDLSYNRLSGPFPSSLQGLN-SLQALMLKGNT 312 N + + L +L LD+S N LS G+ +L+ L L N Sbjct: 605 RGNHLDVLWRDGDNRYLQLFKNLLKLEELDISKNSLSFLPSGVFDGMPPNLKNLSLAKNG 664 Query: 313 KFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFR 372 + + LKNL L LS+ + + SL+ L L+ N + + Sbjct: 665 --LKSFIWEKLRYLKNLETLDLSHNQLTTVPERLSNCSRSLKNLILKNNQIRSLTKYFLQ 722 Query: 373 DVKHLSELRLNDNSLTGPVPFE-RDTVWRMRRKLRLYNNAGLCV 415 D L L L+ N + + V + L L++N LC Sbjct: 723 DAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLLHHNRFLCT 766 Score = 113 bits (282), Expect = 2e-25, Method: Composition-based stats. Identities = 80/395 (20%), Positives = 140/395 (35%), Gaps = 55/395 (13%) Query: 77 IPDVCRGRWHGIECMPDQDNVYHVVSLSFGALSDDTAFPTCDPQRSYVSESLTRLKHLKA 136 IPD+ +H + + + D + V + G+ S+ C + S + L +LK+ Sbjct: 55 IPDISPASFHRLVHLVEIDFRCNCVPIRLGSKSN-----MCPRRLQIKPRSFSGLTYLKS 109 Query: 137 LFFYRC-LGRAPQRIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDL-HKNH 194 L+ L PQ +P L L N ++L L N+++L L + Sbjct: 110 LYLDGNQLLEIPQGLPPSLQLLSL-------EANNIFSIRKEQLTELANIEILYLGQNCY 162 Query: 195 LN-------GSIPLSFNRFSGLRSLDLSGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPP 247 +F + L+ L L N +T ++P + L+ L L N++ Sbjct: 163 YRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVT-TVPTVLPSTLTELYLYNNMIAEIQED 221 Query: 248 TLTSCGSLIKIDLS-----------------RNRVTGPIPESINRLNQLVLLDLSYNRLS 290 + L +DLS N + + L +L +L L N L Sbjct: 222 DFNNLNQLQILDLSGNCPRCYNAPFPCTPCKNNSPLQIPVNAFDALTELKVLRLHSNSLQ 281 Query: 291 GPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNT------NIQGSIP 344 P + +N+LQ L L N L NL+ L LS ++ Sbjct: 282 HVPPRWFKNINNLQELDLSQNFLAKEIGDAKFLHFLPNLIQLDLSFNFELQVYRASMNLS 341 Query: 345 KSLTRLNSLRVLHLEG---NNLTGEIPLEFRDVKHLSELRLNDNSLTGPVPFERDTVWRM 401 ++ + L SL++L + G L ++++L L L N F + M Sbjct: 342 QAFSSLKSLKILRIRGYVFKELKSFQLSPLHNLQNLEVLDLGTN-------FIKIANLSM 394 Query: 402 RRKLRLYNNAGLCVNRDSDLDDAFGSKSGSTVRLC 436 ++ + L VN+ S D+ + S R Sbjct: 395 FKQFKRLKVIDLSVNKISPSGDSLVPRGSSNARTS 429 Score = 91.8 bits (226), Expect = 6e-19, Method: Composition-based stats. Identities = 61/322 (18%), Positives = 100/322 (31%), Gaps = 17/322 (5%) Query: 30 DSTAPSALIDGPQTGFTMTNDGARTEPDEQDAVYDIMRATGNDWAAAIP--DVCRGRWHG 87 D A S + FT + D + + + + + Sbjct: 447 DKYARSCRFKNKEASFTSVQESCYKYGQTLDLSKNSIFFIKSSDFQHLSFLKCLNLSGNL 506 Query: 88 IECMPDQDNVYHVVSLSFGALSDDTAFPTCDPQRSYVSESLTRLKHLKALFFYRCLGRAP 147 I + + L + S++ D S E L +L+ L Sbjct: 507 ISQTLNGSEFQPLAELRYLDFSNNRL----DLLHSTAFEELRKLEVLDISSNSHYFQSEG 562 Query: 148 QRIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGS-------IP 200 + LQ L++ +N + + +L+ L+ NHL+ Sbjct: 563 ITHMLNFTKNLKVLQKLMMNDNDISSSTSRTMES-ESLRTLEFRGNHLDVLWRDGDNRYL 621 Query: 201 LSFNRFSGLRSLDLSGNRLTGSIPG---FVLPALSVLDLNQNLLTGPVPPTLTSCGSLIK 257 F L LD+S N L+ G + P L L L +N L + L +L Sbjct: 622 QLFKNLLKLEELDISKNSLSFLPSGVFDGMPPNLKNLSLAKNGLKSFIWEKLRYLKNLET 681 Query: 258 IDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTT 317 +DLS N++T N L L L N++ LQ L+ L L N Sbjct: 682 LDLSHNQLTTVPERLSNCSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQ 741 Query: 318 IPENAFKGLKNLMILVLSNTNI 339 L NL +L+L + Sbjct: 742 KTSFPENVLNNLKMLLLHHNRF 763 Score = 89.1 bits (219), Expect = 4e-18, Method: Composition-based stats. Identities = 66/294 (22%), Positives = 109/294 (37%), Gaps = 34/294 (11%) Query: 94 QDNVYHVVSLSFGALSDDTAFPTCDPQRSYVSESLTRLKHLKALFFYRCLGRAPQRIPAF 153 + H+ L LS + T + + L L++L L + + Sbjct: 488 SSDFQHLSFLKCLNLSGNLISQTLNGSEF---QPLAELRYLDFSNNRLDL------LHST 538 Query: 154 LGRLGSSLQTLVLRENGFL------GPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFS 207 L+ L + N + + NL L+ L ++ N ++ S + Sbjct: 539 AFEELRKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSSTSRTMES-E 597 Query: 208 GLRSLDLSGNRLTGSIPGFV---------LPALSVLDLNQNLLTGPVPPTLTSCG-SLIK 257 LR+L+ GN L L L LD+++N L+ +L Sbjct: 598 SLRTLEFRGNHLDVLWRDGDNRYLQLFKNLLKLEELDISKNSLSFLPSGVFDGMPPNLKN 657 Query: 258 IDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTT 317 + L++N + I E + L L LDLS+N+L+ SL+ L+LK N S T Sbjct: 658 LSLAKNGLKSFIWEKLRYLKNLETLDLSHNQLTTVPERLSNCSRSLKNLILKNNQIRSLT 717 Query: 318 --IPENAFKGLKNLMILVLSNTNIQGSIPKSLTR--LNSLRVLHLEGNNLTGEI 367 ++AF+ L L LS+ IQ S LN+L++L L N Sbjct: 718 KYFLQDAFQ----LRYLDLSSNKIQMIQKTSFPENVLNNLKMLLLHHNRFLCTC 767 Score = 85.6 bits (210), Expect = 5e-17, Method: Composition-based stats. Identities = 72/353 (20%), Positives = 123/353 (34%), Gaps = 43/353 (12%) Query: 142 CLGRAPQRIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPL 201 C +P +IP + L+ L L N P N+ NL+ LDL +N L I Sbjct: 251 CKNNSPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINNLQELDLSQNFLAKEIGD 310 Query: 202 S--FNRFSGLRSLDLSGN--------RLTGSIPGFVLPALSVLDLN---QNLLTGPVPPT 248 + + L LDLS N + S L +L +L + L Sbjct: 311 AKFLHFLPNLIQLDLSFNFELQVYRASMNLSQAFSSLKSLKILRIRGYVFKELKSFQLSP 370 Query: 249 LTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLS------------------ 290 L + +L +DL N + + +L ++DLS N++S Sbjct: 371 LHNLQNLEVLDLGTNFIKIANLSMFKQFKRLKVIDLSVNKISPSGDSLVPRGSSNARTSV 430 Query: 291 -GPFPSSLQGLNSLQALMLKGNTKFS---TTIPENAFKGLKNLMILVLSNTNIQGSIPKS 346 P L+ L + + +F + K L LS +I Sbjct: 431 ESYEPQVLEQLYYFRYDKYARSCRFKNKEASFTSVQESCYKYGQTLDLSKNSIFFIKSSD 490 Query: 347 LTRLNSLRVLHLEGNNLTGEI-PLEFRDVKHLSELRLNDNSLTGPVPFERDTVWRMRRKL 405 L+ L+ L+L GN ++ + EF+ + L L ++N L + R L Sbjct: 491 FQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRL-DLLHSTAFEELRKLEVL 549 Query: 406 RLYNNAGLCVNR--DSDLDDAFGSKSGSTVRLCDAE----TSRPAPSGTVQHL 452 + +N+ + L+ K + + D + TSR S +++ L Sbjct: 550 DISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSSTSRTMESESLRTL 602 Score = 58.3 bits (139), Expect = 8e-09, Method: Composition-based stats. Identities = 48/220 (21%), Positives = 77/220 (35%), Gaps = 45/220 (20%) Query: 207 SGLRSLDLSGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRN--- 263 +D + LT IPG + + L L N + P + L++ID N Sbjct: 22 KNHVIVDCTDKHLT-EIPGGIPTNTTNLTLTINHIPDISPASFHRLVHLVEIDFRCNCVP 80 Query: 264 -----------RVTGPIPESINRLNQLVLLDLSYNRLSGPFPSS---------------- 296 R P S + L L L L N+L Sbjct: 81 IRLGSKSNMCPRRLQIKPRSFSGLTYLKSLYLDGNQLLEIPQGLPPSLQLLSLEANNIFS 140 Query: 297 -----LQGLNSLQALMLKGNTKF------STTIPENAFKGLKNLMILVLSNTNIQGSIPK 345 L L +++ L L N + S +I ++AF L L +L L + N+ ++P Sbjct: 141 IRKEQLTELANIEILYLGQNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNV-TTVPT 199 Query: 346 SLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLNDN 385 L +L L+L N + +F ++ L L L+ N Sbjct: 200 VLPS--TLTELYLYNNMIAEIQEDDFNNLNQLQILDLSGN 237 >5MX0-A nrPDB Length = 362 Score = 103 bits (256), Expect = 2e-22, Method: Composition-based stats. Identities = 62/244 (25%), Positives = 100/244 (40%), Gaps = 18/244 (7%) Query: 149 RIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPL--SFNRF 206 R +L + S ++ + + N N T L + LH N + F++ Sbjct: 81 RNLKYLPFVPSRMKYVYFQNNQITSIQEGVFDNATGLLWIALHGNQITSDKVGRKVFSKL 140 Query: 207 SGLRSLDLSGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVT 266 L L L N LT +PG + +L L L+ N ++ L +L + L N + Sbjct: 141 RHLERLYLDHNNLTR-MPGPLPRSLRELHLDHNQISRVPNNALEGLENLTALYLQHNEIQ 199 Query: 267 GPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNS-LQALMLKGNTKFSTTIPENAFKG 325 L L+LLDLSYN L GL S L+ L ++ N + T+P++ F+G Sbjct: 200 EVGSSM-RGLRSLILLDLSYNHLRKVPD----GLPSALEQLYMEHNNVY--TVPDSYFRG 252 Query: 326 LKNLMILVLSNTNI--QGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLN 383 L+ + LS+ ++ G + +SL L L N L P+ +L L L Sbjct: 253 APKLLYVRLSHNSLTNNGLASNTF-NSSSLLELDLSYNQLQKIPPVN----TNLENLYLQ 307 Query: 384 DNSL 387 N + Sbjct: 308 GNRI 311 Score = 88.7 bits (218), Expect = 5e-18, Method: Composition-based stats. Identities = 72/326 (22%), Positives = 109/326 (33%), Gaps = 40/326 (12%) Query: 33 APSALIDGP-QTGFTMTNDGARTEPDEQDAVYDIMRAT--GNDWAAAIPDVCRGRWHGIE 89 +PS + +GP T + + R P E D + A N +P V + Sbjct: 39 SPSGVDEGPASTSGSPSPPDPRDCPQECDCPPNFPTAMYCDNRNLKYLPFVPSRMKYVYF 98 Query: 90 CMPDQDNVYHVVSLSFGALSDDTAFPTCDPQRSYVSESLTRLKHLKALFF-YRCLGRAPQ 148 ++ V + L + ++L+HL+ L+ + L R P Sbjct: 99 QNNQITSIQEGVFDNATGLLWIALHGNQITSDKVGRKVFSKLRHLERLYLDHNNLTRMP- 157 Query: 149 RIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSG 208 G L SL+ L L N + L L NL L L N + S Sbjct: 158 ------GPLPRSLRELHLDHNQISRVPNNALEGLENLTALYLQHNEIQEV-GSSMRGLRS 210 Query: 209 LRSLDLSGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVT-- 266 L LDLS N L +P + AL L + N + L+ + LS N +T Sbjct: 211 LILLDLSYNHLRK-VPDGLPSALEQLYMEHNNVYTVPDSYFRGAPKLLYVRLSHNSLTNN 269 Query: 267 GPIPESINRL-------------------NQLVLLDLSYNRLSGPFPSSLQGL------N 301 G + N L L L NR++ SS + + Sbjct: 270 GLASNTFNSSSLLELDLSYNQLQKIPPVNTNLENLYLQGNRINEFSISSFCTVVDVVNFS 329 Query: 302 SLQALMLKGNTKFSTTIPENAFKGLK 327 LQ L L GN + +P +A L+ Sbjct: 330 KLQVLRLDGNEIKRSAMPADAPLCLR 355 Score = 61.0 bits (146), Expect = 1e-09, Method: Composition-based stats. Identities = 32/147 (21%), Positives = 55/147 (37%), Gaps = 11/147 (7%) Query: 277 NQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSN 336 +++ + N+++ L + L GN S + F L++L L L + Sbjct: 91 SRMKYVYFQNNQITSIQEGVFDNATGLLWIALHGNQITSDKVGRKVFSKLRHLERLYLDH 150 Query: 337 TNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLNDNSLTGPVPFERD 396 N+ +P L SLR LHL+ N ++ +++L+ L L N + Sbjct: 151 NNL-TRMPGPLP--RSLRELHLDHNQISRVPNNALEGLENLTALYLQHNEI--------Q 199 Query: 397 TVWRMRRKLRLYNNAGLCVNRDSDLDD 423 V R LR L N + D Sbjct: 200 EVGSSMRGLRSLILLDLSYNHLRKVPD 226 >3A79-B nrPDB Length = 562 Score = 100 bits (249), Expect = 1e-21, Method: Composition-based stats. Identities = 39/136 (28%), Positives = 67/136 (49%), Gaps = 10/136 (7%) Query: 159 SSLQTLVLRENGFLGPIPDEL--GNLTNLKVLDLHKNHLNGSIPLSFNRFS----GLRSL 212 LQTL+L+ NG L N+++L+ LD+ N LN +++R + L Sbjct: 377 KRLQTLILQRNGLKNFFKVALMTKNMSSLETLDVSLNSLNSH---AYDRTCAWAESILVL 433 Query: 213 DLSGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPES 272 +LS N LTGS+ + P + VLDL+ N + P +T +L +++++ N++ Sbjct: 434 NLSSNMLTGSVFRCLPPKVKVLDLHNNRIMSI-PKDVTHLQALQELNVASNQLKSVPDGV 492 Query: 273 INRLNQLVLLDLSYNR 288 +RL L + L N Sbjct: 493 FDRLTSLQYIWLHDNP 508 Score = 72.5 bits (176), Expect = 4e-13, Method: Composition-based stats. Identities = 58/298 (19%), Positives = 105/298 (35%), Gaps = 19/298 (6%) Query: 100 VVSLSFGALSDDTAFPTCDPQRSYVSESLTRLKHLKALFFYRCLGRAPQRIPAFLGRLGS 159 V +L LS+ + LTR L + + F Sbjct: 217 VNALGHLQLSNIKLNDENCQRLMTFLSELTRGPTLLNVTLQHIETTWKCSVKLFQFFWPR 276 Query: 160 SLQTLVLRENGFLGPIPDE--LGNLTNLKVLDLHK--NHL----NGSIPLSFNRFSGLRS 211 ++ L + I E + T LK L + N + ++ F ++ Sbjct: 277 PVEYLNIYNLTITERIDREEFTYSETALKSLMIEHVKNQVFLFSKEALYSVFAEM-NIKM 335 Query: 212 LDLSGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPE 271 L +S + + + L+ QN+ T V ++ L + L RN + Sbjct: 336 LSISDTPFIHMVCPPSPSSFTFLNFTQNVFTDSVFQGCSTLKRLQTLILQRNGLKNFFKV 395 Query: 272 SI--NRLNQLVLLDLSYNRLSG-PFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLK- 327 ++ ++ L LD+S N L+ + + S+ L L N + + F+ L Sbjct: 396 ALMTKNMSSLETLDVSLNSLNSHAYDRTCAWAESILVLNLSSN-----MLTGSVFRCLPP 450 Query: 328 NLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLNDN 385 + +L L N I PK +T L +L+ L++ N L F + L + L+DN Sbjct: 451 KVKVLDLHNNRIMSI-PKDVTHLQALQELNVASNQLKSVPDGVFDRLTSLQYIWLHDN 507 Score = 71.4 bits (173), Expect = 9e-13, Method: Composition-based stats. Identities = 54/223 (24%), Positives = 83/223 (37%), Gaps = 19/223 (8%) Query: 138 FFYRCLGRAPQRIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNG 197 + R L P+ +P + L L +N ++ L+ L+VL L N + Sbjct: 38 YSNRNLTHVPKDLPPRT-------KALSLSQNSISELRMPDISFLSELRVLRLSHNRIRS 90 Query: 198 SIPLSFNRFSGLRSLDLSGNRLTGSIPGFVLPALSVLDLNQNLLTG-PVPPTLTSCGSLI 256 F L LD+S NRL I + +L LDL+ N PV + L Sbjct: 91 LDFHVFLFNQDLEYLDVSHNRLQN-ISCCPMASLRHLDLSFNDFDVLPVCKEFGNLTKLT 149 Query: 257 KIDLSRNRVTGPIPESINRLN-QLVLLDLSYNRLSGPFPSSLQGLNSLQALML--KGNTK 313 + LS + + L+ +LLDL + G SLQ + + L L N+ Sbjct: 150 FLGLSAAKFRQLDLLPVAHLHLSCILLDLVSYHIKGGETESLQ-IPNTTVLHLVFHPNSL 208 Query: 314 FSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVL 356 FS + + L L LSN + + L + L L Sbjct: 209 FSVQVNMSV----NALGHLQLSNIKLNDENCQRL--MTFLSEL 245 Score = 67.5 bits (163), Expect = 1e-11, Method: Composition-based stats. Identities = 34/124 (27%), Positives = 50/124 (40%), Gaps = 5/124 (4%) Query: 212 LDLSGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPE 271 +D S LT +P + P L L+QN ++ P ++ L + LS NR+ Sbjct: 36 VDYSNRNLTH-VPKDLPPRTKALSLSQNSISELRMPDISFLSELRVLRLSHNRIRSLDFH 94 Query: 272 SINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMI 331 L LD+S+NRL + SL+ L L N + + F L L Sbjct: 95 VFLFNQDLEYLDVSHNRLQNISCC---PMASLRHLDLSFNDFDVLPVCKE-FGNLTKLTF 150 Query: 332 LVLS 335 L LS Sbjct: 151 LGLS 154 Score = 64.8 bits (156), Expect = 7e-11, Method: Composition-based stats. Identities = 49/240 (20%), Positives = 91/240 (37%), Gaps = 21/240 (8%) Query: 142 CLGRAPQRIPAFLGRLGSSLQTLVLRE--NGFLGPIPDELGNL---TNLKVLDLHKN-HL 195 L + ++L++L++ N + L ++ N+K+L + + Sbjct: 285 NLTITERIDREEFTYSETALKSLMIEHVKNQVFLFSKEALYSVFAEMNIKMLSISDTPFI 344 Query: 196 NGSIPLSFNRFSGLRSLDLSGNRLTGSIPGFV--LPALSVLDLNQNLLTGPVPPTL--TS 251 + P S + F L+ + N T S+ L L L L +N L L + Sbjct: 345 HMVCPPSPSSF---TFLNFTQNVFTDSVFQGCSTLKRLQTLILQRNGLKNFFKVALMTKN 401 Query: 252 CGSLIKIDLSRNRVTGPIPE-SINRLNQLVLLDLSYNRLSGPFPSSLQGLN-SLQALMLK 309 SL +D+S N + + + +++L+LS N L+G S + L ++ L L Sbjct: 402 MSSLETLDVSLNSLNSHAYDRTCAWAESILVLNLSSNMLTG---SVFRCLPPKVKVLDLH 458 Query: 310 GNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPL 369 N S L+ L L +++ ++ RL SL+ + L N P Sbjct: 459 NNRIMSI---PKDVTHLQALQELNVASNQLKSVPDGVFDRLTSLQYIWLHDNPWDCTCPG 515 Score = 59.8 bits (143), Expect = 2e-09, Method: Composition-based stats. Identities = 47/209 (22%), Positives = 76/209 (36%), Gaps = 10/209 (4%) Query: 161 LQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLT 220 L+++V N L +P +L T L L +N ++ + S LR L LS NR+ Sbjct: 32 LESMVDYSNRNLTHVPKDLPPRTK--ALSLSQNSISELRMPDISFLSELRVLRLSHNRIR 89 Query: 221 GSIPGFVL--PALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIP-ESINRLN 277 L L LD++ N L + SL +DLS N + L Sbjct: 90 SLDFHVFLFNQDLEYLDVSHNRLQNI---SCCPMASLRHLDLSFNDFDVLPVCKEFGNLT 146 Query: 278 QLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNT 337 +L L LS + + L+ L ++L + + + + N +L L Sbjct: 147 KLTFLGLSAAKFRQLDLLPVAHLH-LSCILLDLVSYHIKGGETESLQ-IPNTTVLHLVFH 204 Query: 338 NIQGSIPKSLTRLNSLRVLHLEGNNLTGE 366 + +N+L L L L E Sbjct: 205 PNSLFSVQVNMSVNALGHLQLSNIKLNDE 233 Score = 53.6 bits (127), Expect = 2e-07, Method: Composition-based stats. Identities = 35/151 (23%), Positives = 67/151 (44%), Gaps = 6/151 (3%) Query: 250 TSCGSLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSL--QGLNSLQALM 307 S S ++ ++N T + + + L +L L L N L F +L + ++SL+ L Sbjct: 350 PSPSSFTFLNFTQNVFTDSVFQGCSTLKRLQTLILQRNGLKNFFKVALMTKNMSSLETLD 409 Query: 308 LKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEI 367 + N+ S +++++L LS+ + GS+ + L ++VL L N + I Sbjct: 410 VSLNSLNSHAYDRTC-AWAESILVLNLSSNMLTGSVFRCLP--PKVKVLDLHNNRIMS-I 465 Query: 368 PLEFRDVKHLSELRLNDNSLTGPVPFERDTV 398 P + ++ L EL + N L D + Sbjct: 466 PKDVTHLQALQELNVASNQLKSVPDGVFDRL 496 >3V44-A nrPDB Length = 407 Score = 98.3 bits (243), Expect = 7e-21, Method: Composition-based stats. Identities = 69/317 (21%), Positives = 105/317 (33%), Gaps = 31/317 (9%) Query: 127 SLTRLKHLKALFFYRCLGRAPQRIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLK 186 S +RL+ L+ L + R F G SSL L L N FL L NL+ Sbjct: 49 SFSRLQDLQFLKVEQQTPGLVIRNNTFRG--LSSLIILKLDYNQFLQLETGAFNGLANLE 106 Query: 187 VLDLHKNHLNGSIPL--SFNRFSGLRSLDLSGNRLTGSIPGFVLPALS---VLDLNQNLL 241 VL L + +L+G++ F + L L L N + P + VLDL N + Sbjct: 107 VLTLTQCNLDGAVLSGNFFKPLTSLEMLVLRDNNIKKIQPASFFLNMRRFHVLDLTFNKV 166 Query: 242 TGPVPPTLTSC--GSLIKIDLSRNRVTGPIPESINRLN--------QLVLLDLSYNRLS- 290 L + + LS + + + LDLS N Sbjct: 167 KSICEEDLLNFQGKHFTLLRLSSITLQDMNEYWLGWEKCGNPFKNTSITTLDLSGNGFKE 226 Query: 291 GPFPSSLQGL--NSLQALMLKGNTKFSTTIPENAFKGLKNLM----------ILVLSNTN 338 + +Q+L+L + ++ FK N LS + Sbjct: 227 SMAKRFFDAIAGTKIQSLILSNSYNMGSSFGHTNFKDPDNFTFKGLEASGVKTCDLSKSK 286 Query: 339 IQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLNDNSLTGPVPFERDTV 398 I + + L L L N + F + HL EL L+ N L D + Sbjct: 287 IFALLKSVFSHFTDLEQLTLAQNEINKIDDNAFWGLTHLKELALDTNQLKSVPDGIFDRL 346 Query: 399 WRMRRKLRLYNNAGLCV 415 +K+ L+ N C Sbjct: 347 -TSLQKIWLHTNPWDCS 362 Score = 76.4 bits (186), Expect = 3e-14, Method: Composition-based stats. Identities = 39/165 (23%), Positives = 69/165 (41%), Gaps = 6/165 (3%) Query: 225 GFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRV-TGPIPESINRLNQLVLLD 283 + ++ +DL+ N + + + L + + + + L+ L++L Sbjct: 26 PELPAHVNYVDLSLNSIAELNETSFSRLQDLQFLKVEQQTPGLVIRNNTFRGLSSLIILK 85 Query: 284 LSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSI 343 L YN+ + GL +L+ L L + N FK L +L +LVL + NI+ Sbjct: 86 LDYNQFLQLETGAFNGLANLEVLTLTQCNLDGAVLSGNFFKPLTSLEMLVLRDNNIKKIQ 145 Query: 344 PKS-LTRLNSLRVLHLEGN---NLTGEIPLEFRDVKHLSELRLND 384 P S + VL L N ++ E L F+ KH + LRL+ Sbjct: 146 PASFFLNMRRFHVLDLTFNKVKSICEEDLLNFQG-KHFTLLRLSS 189 >6HKW-A nrPDB Length = 363 Score = 97.9 bits (242), Expect = 8e-21, Method: Composition-based stats. Identities = 61/265 (23%), Positives = 109/265 (41%), Gaps = 22/265 (8%) Query: 178 ELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPGFVLPALSVLDLN 237 L +K L L +N + + LR LDL N++ L L +LD++ Sbjct: 96 GFEVLKKVKTLCLRQNLIK--CIENLEELQSLRELDLYDNQIKKIENLEALTELEILDIS 153 Query: 238 QNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSL 297 NLL + L K+ L N+++ E+++ L+QL +L+L NR+ + Sbjct: 154 FNLLRNI--EGVDKLTRLKKLFLVNNKISKI--ENLSNLHQLQMLELGSNRIRAIEN--I 207 Query: 298 QGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLH 357 L +L++L L N L NL +L + + + + L L +LR L+ Sbjct: 208 DTLTNLESLFLGKNKITKLQ----NLDALTNLTVLSMQSNRLTKI--EGLQNLVNLRELY 261 Query: 358 LEGNNLTGEIPLEFRDVKHLSELRLNDNSLTGPVPFERDTVWRMRRKLRLYNNAGLCVNR 417 L N + E+ + L+ L + N + E + ++ + +N + Sbjct: 262 LSHNGI--EVIEGLENNNKLTMLDIASNRIKKI---ENISHLTELQEFWMNDNL---LES 313 Query: 418 DSDLDDAFGSKSGSTVRLCDAETSR 442 SDLD+ G++S TV L + Sbjct: 314 WSDLDELKGARSLETVYLERNPLQK 338 Score = 85.2 bits (209), Expect = 7e-17, Method: Composition-based stats. Identities = 54/246 (21%), Positives = 89/246 (36%), Gaps = 20/246 (8%) Query: 125 SESLTRLKHLKALFFYRCLGRAPQRIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTN 184 E+L L+ L+ L Y Q + L+ L + N + + LT Sbjct: 116 IENLEELQSLRELDLYDN-----QIKKIENLEALTELEILDISFNLLRNI--EGVDKLTR 168 Query: 185 LKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPGFVLPALSVLDLNQNLLTGP 244 LK L L N ++ + + L+ L+L NR+ L L L L +N +T Sbjct: 169 LKKLFLVNNKISKI--ENLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKL 226 Query: 245 VPPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQ 304 L + +L + + NR+T E + L L L LS+N + L+ N L Sbjct: 227 --QNLDALTNLTVLSMQSNRLTKI--EGLQNLVNLRELYLSHNGIEVIEG--LENNNKLT 280 Query: 305 ALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIP-KSLTRLNSLRVLHLEGNNL 363 L + N L L +++ ++ L SL ++LE N L Sbjct: 281 MLDIASNRIKKI----ENISHLTELQEFWMNDNLLESWSDLDELKGARSLETVYLERNPL 336 Query: 364 TGEIPL 369 + Sbjct: 337 QKDPQY 342 >5GY2-A nrPDB Length = 455 Score = 96.8 bits (239), Expect = 2e-20, Method: Composition-based stats. Identities = 54/297 (18%), Positives = 90/297 (30%), Gaps = 78/297 (26%) Query: 149 RIPAFLGRLGSSLQTLVLRENGFLGPIPDEL-GNLTNLKVLDLHKNHLNGSIPLSFNRF- 206 + + +SL+ LVLR+N P N+ VLDL N + F Sbjct: 119 VLSGNFFKPLTSLEMLVLRDNNIKKIQPASFFLNMRRFHVLDLTFNKVKSICEEDLLNFQ 178 Query: 207 ---------------------------------SGLRSLDLSGNRLTGSI---------- 223 + + +LDLSGN S+ Sbjct: 179 GKHFTLLRLSSITLQDMNEYWLGWEKCGNPFKNTSITTLDLSGNGFKESMAKRFFDAIAG 238 Query: 224 -------------------------------PGFVLPALSVLDLNQNLLTGPVPPTLTSC 252 G + DL+++ + + + Sbjct: 239 TKIQSLILSNSYNMGSSFGHTNFKDPDNFTFKGLEASGVKTCDLSKSKIFALLKSVFSHF 298 Query: 253 GSLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNT 312 L ++ L++N + + L L+ L+LS N L + L+ L+ L L N Sbjct: 299 TDLEQLTLAQNEINKIDDNAFWGLTHLLKLNLSQNFLGSIDSRMFENLDKLEVLDLSYN- 357 Query: 313 KFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPL 369 + + +F GL NL L L ++ RL SL+ + L N P Sbjct: 358 -HIRALGDQSFLGLPNLKELALDTNQLKSVPDGIFDRLTSLQKIWLHTNPWDCSCPR 413 Score = 95.2 bits (235), Expect = 6e-20, Method: Composition-based stats. Identities = 65/336 (19%), Positives = 103/336 (30%), Gaps = 55/336 (16%) Query: 127 SLTRLKHLKALFFYRCLGRAPQRIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLK 186 S +RL+ L+ L + R F G SSL L L N FL L NL+ Sbjct: 49 SFSRLQDLQFLKVEQQTPGLVIRNNTFRG--LSSLIILKLDYNQFLQLETGAFNGLANLE 106 Query: 187 VLDLHKNHLNGSIPL--SFNRFSGLRSLDLSGNRLTGSIPGFVLPALS---VLDLNQNLL 241 VL L + +L+G++ F + L L L N + P + VLDL N + Sbjct: 107 VLTLTQCNLDGAVLSGNFFKPLTSLEMLVLRDNNIKKIQPASFFLNMRRFHVLDLTFNKV 166 Query: 242 TGPVPPTLTSC--GSLIKIDLSRNRVTGPIPESINRLN--------QLVLLDLSYNRLS- 290 L + + LS + + + LDLS N Sbjct: 167 KSICEEDLLNFQGKHFTLLRLSSITLQDMNEYWLGWEKCGNPFKNTSITTLDLSGNGFKE 226 Query: 291 GPFPSSLQGL--NSLQALMLKGNTKFSTTIPE---------------------------- 320 + +Q+L+L + ++ Sbjct: 227 SMAKRFFDAIAGTKIQSLILSNSYNMGSSFGHTNFKDPDNFTFKGLEASGVKTCDLSKSK 286 Query: 321 ------NAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRDV 374 + F +L L L+ I + L L L+L N L F ++ Sbjct: 287 IFALLKSVFSHFTDLEQLTLAQNEINKIDDNAFWGLTHLLKLNLSQNFLGSIDSRMFENL 346 Query: 375 KHLSELRLNDNSLTGPVPFERDTVWRMRRKLRLYNN 410 L L L+ N + + ++L L N Sbjct: 347 DKLEVLDLSYNHIRALGDQSFLGLP-NLKELALDTN 381 Score = 74.8 bits (182), Expect = 8e-14, Method: Composition-based stats. Identities = 39/165 (23%), Positives = 69/165 (41%), Gaps = 6/165 (3%) Query: 225 GFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRV-TGPIPESINRLNQLVLLD 283 + ++ +DL+ N + + + L + + + + L+ L++L Sbjct: 26 PELPAHVNYVDLSLNSIAELNETSFSRLQDLQFLKVEQQTPGLVIRNNTFRGLSSLIILK 85 Query: 284 LSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSI 343 L YN+ + GL +L+ L L + N FK L +L +LVL + NI+ Sbjct: 86 LDYNQFLQLETGAFNGLANLEVLTLTQCNLDGAVLSGNFFKPLTSLEMLVLRDNNIKKIQ 145 Query: 344 PKS-LTRLNSLRVLHLEGN---NLTGEIPLEFRDVKHLSELRLND 384 P S + VL L N ++ E L F+ KH + LRL+ Sbjct: 146 PASFFLNMRRFHVLDLTFNKVKSICEEDLLNFQG-KHFTLLRLSS 189 >2Z7X-B nrPDB Length = 520 Score = 83.7 bits (205), Expect = 2e-16, Method: Composition-based stats. Identities = 32/133 (24%), Positives = 63/133 (47%), Gaps = 4/133 (3%) Query: 159 SSLQTLVLRENGFLGP--IPDELGNLTNLKVLDLHKNHLN-GSIPLSFNRFSGLRSLDLS 215 + L+TL+L+ N I + + +L+ LD+ +N ++ + L SL++S Sbjct: 348 TELETLILQMNQLKELSKIAEMTTQMKSLQQLDISQNSVSYDEKKGDCSWTKSLLSLNMS 407 Query: 216 GNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINR 275 N LT +I + P + VLDL+ N + P + +L +++++ N++ +R Sbjct: 408 SNILTDTIFRCLPPRIKVLDLHSNKIKSI-PKQVVKLEALQELNVASNQLKSVPDGIFDR 466 Query: 276 LNQLVLLDLSYNR 288 L L + L N Sbjct: 467 LTSLQKIWLHTNP 479 Score = 68.3 bits (165), Expect = 7e-12, Method: Composition-based stats. Identities = 42/193 (21%), Positives = 75/193 (38%), Gaps = 11/193 (5%) Query: 197 GSIPLSFNRFSGLRSLDLSGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLI 256 I F+ +++ +SG R+ + + LD + NLLT V L Sbjct: 293 SYIYEIFSNM-NIKNFTVSGTRMVHMLCPSKISPFLHLDFSNNLLTDTVFENCGHLTELE 351 Query: 257 KIDLSRNRVTGP--IPESINRLNQLVLLDLSYNRLSGPFP-SSLQGLNSLQALMLKGNTK 313 + L N++ I E ++ L LD+S N +S SL +L + N Sbjct: 352 TLILQMNQLKELSKIAEMTTQMKSLQQLDISQNSVSYDEKKGDCSWTKSLLSLNMSSNIL 411 Query: 314 FSTTIPENAFKGLK-NLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFR 372 T F+ L + +L L + I+ + + L +L+ L++ N L F Sbjct: 412 TDT-----IFRCLPPRIKVLDLHSNKIKSIPKQVVK-LEALQELNVASNQLKSVPDGIFD 465 Query: 373 DVKHLSELRLNDN 385 + L ++ L+ N Sbjct: 466 RLTSLQKIWLHTN 478 Score = 67.1 bits (162), Expect = 2e-11, Method: Composition-based stats. Identities = 42/172 (24%), Positives = 71/172 (41%), Gaps = 12/172 (6%) Query: 204 NRFSGLRSLDLSGNRLTGSIPGFV--LPALSVLDLNQNLLTGP--VPPTLTSCGSLIKID 259 ++ S LD S N LT ++ L L L L N L + T SL ++D Sbjct: 321 SKISPFLHLDFSNNLLTDTVFENCGHLTELETLILQMNQLKELSKIAEMTTQMKSLQQLD 380 Query: 260 LSRNRVT-GPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLN-SLQALMLKGNTKFSTT 317 +S+N V+ + L+ L++S N L+ + + L ++ L L N + Sbjct: 381 ISQNSVSYDEKKGDCSWTKSLLSLNMSSNILT---DTIFRCLPPRIKVLDLHSNK--IKS 435 Query: 318 IPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPL 369 IP+ K L+ L L +++ ++ RL SL+ + L N P Sbjct: 436 IPKQVVK-LEALQELNVASNQLKSVPDGIFDRLTSLQKIWLHTNPWDCSCPR 486 Score = 63.7 bits (153), Expect = 2e-10, Method: Composition-based stats. Identities = 53/241 (21%), Positives = 93/241 (38%), Gaps = 23/241 (9%) Query: 212 LDLSGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPE 271 +D S N L +P + ++L+++QN ++ + S L + +S NR+ Sbjct: 5 VDRSKNGLIH-VPKDLSQKTTILNISQNYISELWTSDILSLSKLRILIISHNRIQYLDIS 63 Query: 272 SINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMI 331 +L LDLS+N+L +L+ L L N + I + F + L Sbjct: 64 VFKFNQELEYLDLSHNKLVKISCH---PTVNLKHLDLSFNAFDALPICKE-FGNMSQLKF 119 Query: 332 LVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLNDNSLTGPV 391 L LS T+++ S + LN +VL + GE E D + L + SL Sbjct: 120 LGLSTTHLEKSSVLPIAHLNISKVLLV-----LGETYGEKEDPEGLQDFNTE--SLHIVF 172 Query: 392 PFERDTVWRMRRKLRLYNNAGL-----------CVNRDSDLDDAFGSKSGSTVRLCDAET 440 P ++ + + ++ N L C S L + S + L + ET Sbjct: 173 PTNKEFHFILDVSVKTVANLELSNIKCVLEDNKCSYFLSILAKLQTNPKLSNLTLNNIET 232 Query: 441 S 441 + Sbjct: 233 T 233 Score = 54.0 bits (128), Expect = 2e-07, Method: Composition-based stats. Identities = 27/115 (23%), Positives = 43/115 (37%), Gaps = 2/115 (1%) Query: 164 LVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSI 223 L + +N ++ +L+ L++L + N + F L LDLS N+L I Sbjct: 26 LNISQNYISELWTSDILSLSKLRILIISHNRIQYLDISVFKFNQELEYLDLSHNKLVK-I 84 Query: 224 PGFVLPALSVLDLNQNLLTG-PVPPTLTSCGSLIKIDLSRNRVTGPIPESINRLN 277 L LDL+ N P+ + L + LS + I LN Sbjct: 85 SCHPTVNLKHLDLSFNAFDALPICKEFGNMSQLKFLGLSTTHLEKSSVLPIAHLN 139 Score = 53.3 bits (126), Expect = 2e-07, Method: Composition-based stats. Identities = 42/238 (17%), Positives = 77/238 (32%), Gaps = 33/238 (13%) Query: 186 KVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPGFVLPALSVLDLNQNLLTGPV 245 +L++ +N+++ S LR L +S NR+ LD++ Sbjct: 24 TILNISQNYISELWTSDILSLSKLRILIISHNRI------------QYLDIS-------- 63 Query: 246 PPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSGPFPS-SLQGLNSLQ 304 L +DLS N++ L L DLS+N ++ L+ Sbjct: 64 --VFKFNQELEYLDLSHNKLVKISCHPTVNLKHL---DLSFNAFDALPICKEFGNMSQLK 118 Query: 305 ALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLT--RLNSLRVLHLEGNN 362 L L +++ A + + +LVL T + P+ L SL ++ Sbjct: 119 FLGLSTTHLEKSSVLPIAHLNISKV-LLVLGETYGEKEDPEGLQDFNTESLHIVFPTNKE 177 Query: 363 LTGEIPLEFRDVKHLSELR----LNDNSLTGPVPFERDTVWRMRRKLRLYNNAGLCVN 416 + + + V +L L DN + + + NN N Sbjct: 178 FHFILDVSVKTVANLELSNIKCVLEDNKCSYFLSILAKLQTNPKLSNLTLNNIETTWN 235 Score = 50.6 bits (119), Expect = 2e-06, Method: Composition-based stats. Identities = 38/160 (23%), Positives = 67/160 (41%), Gaps = 7/160 (4%) Query: 258 IDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSGPFPSS--LQGLNSLQALMLKGNTKFS 315 +D S N +T + E+ L +L L L N+L + + SLQ L + N+ Sbjct: 329 LDFSNNLLTDTVFENCGHLTELETLILQMNQLKELSKIAEMTTQMKSLQQLDISQNSVSY 388 Query: 316 TTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVK 375 + K+L+ L +S+ + +I + L ++VL L N + IP + ++ Sbjct: 389 DEKKGDC-SWTKSLLSLNMSSNILTDTIFRCLP--PRIKVLDLHSNKIKS-IPKQVVKLE 444 Query: 376 HLSELRLNDNSLTGPVPFERDTVWRMRRKLRLYNNAGLCV 415 L EL + N L D + +K+ L+ N C Sbjct: 445 ALQELNVASNQLKSVPDGIFDRL-TSLQKIWLHTNPWDCS 483 Score = 39.0 bits (89), Expect = 0.005, Method: Composition-based stats. Identities = 31/188 (16%), Positives = 53/188 (28%), Gaps = 13/188 (6%) Query: 159 SSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNR 218 S L+ L++ N L+ LDL N L L+ LDLS N Sbjct: 45 SKLRILIISHNRIQYLDISVFKFNQELEYLDLSHNKLVKISCH---PTVNLKHLDLSFNA 101 Query: 219 LTGSIPG---FVLPALSVLDLNQNLLTGPVPPTLTSC---GSLIKIDLSRNRVTGPIPES 272 + L L L+ L + L+ + + P Sbjct: 102 FDALPICKEFGNMSQLKFLGLSTTHLEKSSVLPIAHLNISKVLLVLGETYGEKEDPEGLQ 161 Query: 273 INRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALM----LKGNTKFSTTIPENAFKGLKN 328 L ++ + S++ + +L+ L+ N + Sbjct: 162 DFNTESLHIVFPTNKEFHFILDVSVKTVANLELSNIKCVLEDNKCSYFLSILAKLQTNPK 221 Query: 329 LMILVLSN 336 L L L+N Sbjct: 222 LSNLTLNN 229 Score = 37.1 bits (84), Expect = 0.018, Method: Composition-based stats. Identities = 63/384 (16%), Positives = 103/384 (26%), Gaps = 76/384 (19%) Query: 126 ESLTRLKHLKALFFYRCLGRAPQRIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNL 185 + L L+ L Q + + + L+ L L N + NL Sbjct: 39 SDILSLSKLRILIISHNRI---QYLDISVFKFNQELEYLDLSHNKL---VKISCHPTVNL 92 Query: 186 KVLDLHKNHLNGSIP-LSFNRFSGLRSLDLSGNRLTGSI--------------------- 223 K LDL N + F S L+ L LS L S Sbjct: 93 KHLDLSFNAFDALPICKEFGNMSQLKFLGLSTTHLEKSSVLPIAHLNISKVLLVLGETYG 152 Query: 224 PGFVLPALSVLDLNQNLLTGPVPPTL-----TSCGSLIKIDLSRNRVTGPIPESINRLNQ 278 L + + P S ++ ++LS + + L+ Sbjct: 153 EKEDPEGLQDFNTESLHIVFPTNKEFHFILDVSVKTVANLELSNIKCVLEDNKCSYFLSI 212 Query: 279 LVLLD----LSYNRLSGPFPSSLQGLNSLQALMLK-------GNTKFSTTIPENAFK-GL 326 L L LS L+ + + LQ + N K + F Sbjct: 213 LAKLQTNPKLSNLTLNNIETTWNSFIRILQLVWHTTVWYFSISNVKLQGQLDFRDFDYSG 272 Query: 327 KNLMILVL-------------------SNTNIQGSIPKSLTRLNSL--------RVLHLE 359 +L L + SN NI+ ++ L L Sbjct: 273 TSLKALSIHQVVSDVFGFPQSYIYEIFSNMNIKNFTVSGTRMVHMLCPSKISPFLHLDFS 332 Query: 360 GNNLTGEIPLEFRDVKHLSELRLNDNSLTGPVPFERDTV-WRMRRKLRLYNNAGLCVNRD 418 N LT + + L L L N L T + ++L + N V+ D Sbjct: 333 NNLLTDTVFENCGHLTELETLILQMNQLKELSKIAEMTTQMKSLQQLDISQN---SVSYD 389 Query: 419 SDLDDAFGSKSGSTVRLCDAETSR 442 D +KS ++ + + Sbjct: 390 EKKGDCSWTKSLLSLNMSSNILTD 413 >5Y31-B nrPDB Length = 544 Score = 77.5 bits (189), Expect = 1e-14, Method: Composition-based stats. Identities = 31/150 (20%), Positives = 53/150 (35%), Gaps = 26/150 (17%) Query: 222 SIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVL 281 SIP V P + L ++ T + SL + + N ++ L L Sbjct: 40 SIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEY 99 Query: 282 LDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQG 341 L + N + + F+GLK+L+ L L+N N+Q Sbjct: 100 LFIENNNIKSISRHT--------------------------FRGLKSLIHLSLANNNLQT 133 Query: 342 SIPKSLTRLNSLRVLHLEGNNLTGEIPLEF 371 L+SL + L GN+ + L++ Sbjct: 134 LPKDIFKGLDSLTNVDLRGNSFNCDCKLKW 163 Score = 71.7 bits (174), Expect = 7e-13, Method: Composition-based stats. Identities = 24/112 (21%), Positives = 39/112 (34%), Gaps = 2/112 (1%) Query: 207 SGLRSLDLSGNRLTGSIPGFVL--PALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNR 264 + SL + T G L P+L +L N L + + N Sbjct: 47 PDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNN 106 Query: 265 VTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFST 316 + + L L+ L L+ N L +GL+SL + L+GN+ Sbjct: 107 IKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCD 158 Score = 66.7 bits (161), Expect = 2e-11, Method: Composition-based stats. Identities = 30/111 (27%), Positives = 46/111 (41%), Gaps = 2/111 (1%) Query: 277 NQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSN 336 ++ L + + S SLQ L+ N+ I ++AF GL +L L + N Sbjct: 47 PDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSF--DVISDDAFIGLPHLEYLFIEN 104 Query: 337 TNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLNDNSL 387 NI+ + L SL L L NNL F+ + L+ + L NS Sbjct: 105 NNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSF 155 Score = 59.0 bits (141), Expect = 4e-09, Method: Composition-based stats. Identities = 26/126 (20%), Positives = 36/126 (28%), Gaps = 11/126 (8%) Query: 101 VSLSFGALSDDTAFPTCDPQRSYVSESLTRL--------KHLKALFFYRCLGRAPQRIPA 152 +L A S P S+V T + L+ L F I Sbjct: 32 NALCENARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDV---ISD 88 Query: 153 FLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSL 212 L+ L + N L +L L L N+L F L ++ Sbjct: 89 DAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNV 148 Query: 213 DLSGNR 218 DL GN Sbjct: 149 DLRGNS 154 Score = 56.7 bits (135), Expect = 2e-08, Method: Composition-based stats. Identities = 25/109 (22%), Positives = 42/109 (38%), Gaps = 1/109 (0%) Query: 306 LMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTG 365 + L T I E +F +L +L+ ++ + + L L L +E NN+ Sbjct: 50 ISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKS 109 Query: 366 EIPLEFRDVKHLSELRLNDNSLTGPVPFERDTVWRMRRKLRLYNNAGLC 414 FR +K L L L +N+L P + + L N+ C Sbjct: 110 ISRHTFRGLKSLIHLSLANNNLQTL-PKDIFKGLDSLTNVDLRGNSFNC 157 Score = 53.3 bits (126), Expect = 3e-07, Method: Composition-based stats. Identities = 23/94 (24%), Positives = 34/94 (36%), Gaps = 2/94 (2%) Query: 149 RIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSG 208 I SLQ L+ N F D L +L+ L + N++ +F Sbjct: 61 EISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKS 120 Query: 209 LRSLDLSGNRLTGSIPGFV--LPALSVLDLNQNL 240 L L L+ N L L +L+ +DL N Sbjct: 121 LIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNS 154 Score = 40.9 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 21/88 (23%), Positives = 28/88 (31%), Gaps = 3/88 (3%) Query: 109 SDDTAFPTCDPQRSYVSESLTRLKHLKALFFYRCLGRAPQRIPAFLGRLGSSLQTLVLRE 168 S T + ++ L HL+ LF + I R SL L L Sbjct: 72 SLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNI---KSISRHTFRGLKSLIHLSLAN 128 Query: 169 NGFLGPIPDELGNLTNLKVLDLHKNHLN 196 N D L +L +DL N N Sbjct: 129 NNLQTLPKDIFKGLDSLTNVDLRGNSFN 156 >4PUF-A nrPDB Length = 637 Score = 74.4 bits (181), Expect = 9e-14, Method: Composition-based stats. Identities = 53/218 (24%), Positives = 82/218 (37%), Gaps = 23/218 (10%) Query: 184 NLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPGFVLPALSVLDLNQNLLTG 243 + L L N L +L + N+LT SIP + + ++L+ N +T Sbjct: 72 QITTLILDNNELKSLPENLQGNIK---TLYANSNQLT-SIPATLPDTIQEMELSINRITE 127 Query: 244 PVPPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGL--- 300 P L S L +DL N+++ L L + D S L PS + L Sbjct: 128 L-PERLPSA--LQSLDLFHNKISCLPENLPEELRYLSVYDNSIRTLPAHLPSEITHLNVQ 184 Query: 301 -NSLQALMLKGNTKFST-TIPENAFKGL-----KNLMILVLSNTNIQGSIPKSLTRLNSL 353 NSL AL T ENA L L +L +S I +P++L ++ Sbjct: 185 SNSLTALPETLPPGLKTLEAGENALTSLPASLPPELQVLDVSKNQI-TVLPETLP--PTI 241 Query: 354 RVLHLEGNNLTGEIPLEFRDVKHLSELRLNDNSLTGPV 391 L + N LT +P L ++ + N+L Sbjct: 242 TTLDVSRNALTN-LPENLP--AALQIMQASRNNLVRLP 276 Score = 34.8 bits (78), Expect = 0.080, Method: Composition-based stats. Identities = 37/208 (17%), Positives = 67/208 (32%), Gaps = 44/208 (21%) Query: 277 NQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSN 336 Q+ L L N L + + +L N+ T+IP + + LS Sbjct: 71 EQITTLILDNNELKSLPENLQGNIKTL-----YANSNQLTSIPATLPDTI---QEMELSI 122 Query: 337 TNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLS------------------ 378 I +P+ L +L+ L L N ++ ++++LS Sbjct: 123 NRI-TELPERLPS--ALQSLDLFHNKISCLPENLPEELRYLSVYDNSIRTLPAHLPSEIT 179 Query: 379 ELRLNDNSLTGPVPFERDTVWRMRRKLRLYNNAGLCVNRDSDLDDAFGSKSGSTVRLCDA 438 L + NSLT +T+ + L NA + A + + Sbjct: 180 HLNVQSNSLTALP----ETLPPGLKTLEAGENALTSL-------PASLPPELQVLDVSKN 228 Query: 439 ETS----RPAPSGTVQHLSREEDGALPD 462 + + P+ T +SR LP+ Sbjct: 229 QITVLPETLPPTITTLDVSRNALTNLPE 256 >1M9S-A nrPDB Length = 605 Score = 74.1 bits (180), Expect = 1e-13, Method: Composition-based stats. Identities = 41/195 (21%), Positives = 75/195 (38%), Gaps = 14/195 (7%) Query: 204 NRFSGLRSLDLSGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRN 263 N + + + + + + LP ++ L LN N LT P LT+ +L + L N Sbjct: 40 NELNSIDQIIANNSDIKSVQGIQYLPNVTKLFLNGNKLTDIKP--LTNLKNLGWLFLDEN 97 Query: 264 RVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAF 323 ++ + + + L+ +N +S + L L L++L L N T+ Sbjct: 98 KIKDLSSLKDLKKLKSLSLE--HNGISDI--NGLVHLPQLESLYLGNNKITDITV----L 149 Query: 324 KGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLN 383 L L L L + I +P L L L+ L+L N+++ +K+L L L Sbjct: 150 SRLTKLDTLSLEDNQISDIVP--LAGLTKLQNLYLSKNHISDL--RALAGLKNLDVLELF 205 Query: 384 DNSLTGPVPFERDTV 398 + + Sbjct: 206 SQECLNKPINHQSNL 220 Score = 72.5 bits (176), Expect = 4e-13, Method: Composition-based stats. Identities = 45/179 (25%), Positives = 65/179 (36%), Gaps = 31/179 (17%) Query: 163 TLVLRENGFLGPIPDELGNLTNLKVLDLHKNHL-------------------NGSIPLS- 202 L L N P L NL NL L L +N + NG ++ Sbjct: 69 KLFLNGNKLTDIKP--LTNLKNLGWLFLDENKIKDLSSLKDLKKLKSLSLEHNGISDING 126 Query: 203 FNRFSGLRSLDLSGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSR 262 L SL L N++T L L L L N ++ VP L L + LS+ Sbjct: 127 LVHLPQLESLYLGNNKITDITVLSRLTKLDTLSLEDNQISDIVP--LAGLTKLQNLYLSK 184 Query: 263 NRVTGPIPESINRLNQLVLLDL-SYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPE 320 N ++ ++ L L +L+L S L+ P + ++L NT S PE Sbjct: 185 NHISDLR--ALAGLKNLDVLELFSQECLNKP----INHQSNLVVPNTVKNTDGSLVTPE 237 Score = 68.7 bits (166), Expect = 6e-12, Method: Composition-based stats. Identities = 42/191 (21%), Positives = 65/191 (34%), Gaps = 30/191 (15%) Query: 260 LSRNRVTGPIP-----------ESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALML 308 +++N + + I L + L L+ N+L+ P L L +L L L Sbjct: 37 VTQNELNSIDQIIANNSDIKSVQGIQYLPNVTKLFLNGNKLTDIKP--LTNLKNLGWLFL 94 Query: 309 KGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIP 368 N + ++ K + + I L L L L+L N +T Sbjct: 95 DENKIKDLSSLKDLKKLKSLSLE----HNGISDIN--GLVHLPQLESLYLGNNKITDITV 148 Query: 369 LEFRDVKHLSELRLNDNSLTGPVPFERDTVWRMRRKLRLYNNAGLCVNRDSDLDDAFGSK 428 L + L L L DN ++ VP T + N L N SDL G K Sbjct: 149 LS--RLTKLDTLSLEDNQISDIVPLAGLTKLQ---------NLYLSKNHISDLRALAGLK 197 Query: 429 SGSTVRLCDAE 439 + + L E Sbjct: 198 NLDVLELFSQE 208 >4ECN-A nrPDB Length = 876 Score = 71.7 bits (174), Expect = 8e-13, Method: Composition-based stats. Identities = 56/335 (16%), Positives = 105/335 (31%), Gaps = 56/335 (16%) Query: 104 SFGALSDDTAFPTCDPQRSYVSESLTRLKHLKALFFYRCLGRAPQRIPAFLGRL------ 157 + L+D + + + + + L L L++L G + ++ A RL Sbjct: 489 NLKDLTDVELYNCPNMTQ--LPDFLYDLPELQSLNIACNRGISAAQLKADWTRLADDEDT 546 Query: 158 GSSLQTLVLRENGFL-GPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSG 216 G +Q + N P L + L +LD N + +F L L L Sbjct: 547 GPKIQIFYMGYNNLEEFPASASLQKMVKLGLLDCVHNKVR--HLEAFGTNVKLTDLKLDY 604 Query: 217 NRLTGSIPGFV--LPALSVLDLNQNLLTGPV------------PPTLT-----------S 251 N++ F + L + N L + S Sbjct: 605 NQIEEIPEDFCAFTDQVEGLGFSHNKLKYIPNIFNAKSVYVMGSVDFSYNKIGSEGRNIS 664 Query: 252 CG-------SLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNS-- 302 C + + LS N + E + + + LS N ++ +SL+ + Sbjct: 665 CSMDDYKGINASTVTLSYNEIQKFPTELFATGSPISTIILSNNLMTSIPENSLKPKDGNY 724 Query: 303 -----LQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSL--TRLNSL-- 353 L + L+ N S + A L L + +S + L ++L + Sbjct: 725 KNTYLLTTIDLRFNKLTSLSDDFRA-TTLPYLSNMDVSYNCFSSFPTQPLNSSQLKAFGI 783 Query: 354 -RVLHLEGNNLTGEIPLEFRDVKHLSELRLNDNSL 387 EGN + + P L +L++ N + Sbjct: 784 RHQRDAEGNRILRQWPTGITTCPSLIQLQIGSNDI 818 Score = 70.6 bits (171), Expect = 2e-12, Method: Composition-based stats. Identities = 54/342 (15%), Positives = 108/342 (31%), Gaps = 31/342 (9%) Query: 127 SLTRLKHLKALFFYRCLGRAPQRIPAFLGRLGSSLQTLVLREN---------GFLGPIPD 177 S + LK L + Y C ++P FL L LQ+L + N + D Sbjct: 486 SWSNLKDLTDVELYNCPNMT--QLPDFLYDLPE-LQSLNIACNRGISAAQLKADWTRLAD 542 Query: 178 ELGNLTNLKVLDLHKNHLNGSIPLS-FNRFSGLRSLDLSGNRLTGSIPGFVLPALSVLDL 236 + +++ + N+L + + L LD N++ L+ L L Sbjct: 543 DEDTGPKIQIFYMGYNNLEEFPASASLQKMVKLGLLDCVHNKVRHLEAFGTNVKLTDLKL 602 Query: 237 NQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESIN--RLNQLVLLDLSYNRLSG--- 291 + N + + + S N++ IP N + + +D SYN++ Sbjct: 603 DYNQIEEIPEDFCAFTDQVEGLGFSHNKL-KYIPNIFNAKSVYVMGSVDFSYNKIGSEGR 661 Query: 292 PFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSL---- 347 S+ + A + + P F + ++LSN + SL Sbjct: 662 NISCSMDDYKGINASTVTLSYNEIQKFPTELFATGSPISTIILSNNLMTSIPENSLKPKD 721 Query: 348 ---TRLNSLRVLHLEGNNLTGEIPLEFR-DVKHLSELRLNDNSLTGPVPFERDTVWRMRR 403 L + L N LT + +LS + ++ N + ++ + Sbjct: 722 GNYKNTYLLTTIDLRFNKLTSLSDDFRATTLPYLSNMDVSYNCFSSFPTQPLNS--SQLK 779 Query: 404 KLRLYNNAGLCVNRDSDLDD--AFGSKSGSTVRLCDAETSRP 443 + + NR S +++ + + Sbjct: 780 AFGIRHQRDAEGNRILRQWPTGITTCPSLIQLQIGSNDIRKV 821 Score = 64.8 bits (156), Expect = 7e-11, Method: Composition-based stats. Identities = 56/341 (16%), Positives = 103/341 (30%), Gaps = 36/341 (10%) Query: 111 DTAFPTCDPQRSYVSESLTRLKHLKALFFYRC---LGRAPQRIPAFLGRLGSSLQTLVLR 167 DT + +++S+++ RL L+ ++F + L Sbjct: 427 DTQIGNLTNRITFISKAIQRLTKLQIIYFANSPFTYDNIAVDWEDANSDYAKQYENEELS 486 Query: 168 ENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNR--------- 218 + EL N N+ L P L+SL+++ NR Sbjct: 487 WSNLKDLTDVELYNCPNMTQL-----------PDFLYDLPELQSLNIACNRGISAAQLKA 535 Query: 219 -LTGSIPGFVL-PALSVLDLNQNLLTG-PVPPTLTSCGSLIKIDLSRNRVTGPIPESINR 275 T P + + + N L P +L L +D N+V E+ Sbjct: 536 DWTRLADDEDTGPKIQIFYMGYNNLEEFPASASLQKMVKLGLLDCVHNKVRHL--EAFGT 593 Query: 276 LNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLS 335 +L L L YN++ + ++ L N NA K + + + S Sbjct: 594 NVKLTDLKLDYNQIEEIPEDFCAFTDQVEGLGFSHNKLKYIPNIFNA-KSVYVMGSVDFS 652 Query: 336 NTNIQGSIP------KSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLNDNSLTG 389 I +N+ + L N + F +S + L++N +T Sbjct: 653 YNKIGSEGRNISCSMDDYKGINA-STVTLSYNEIQKFPTELFATGSPISTIILSNNLMTS 711 Query: 390 PVPFERDTVWRMRRKLRLYNNAGLCVNRDSDLDDAFGSKSG 430 + L L N+ + L D F + + Sbjct: 712 IPENSLKPKDGNYKNTYLLTTIDLRFNKLTSLSDDFRATTL 752 Score = 52.5 bits (124), Expect = 5e-07, Method: Composition-based stats. Identities = 32/172 (18%), Positives = 55/172 (31%), Gaps = 20/172 (11%) Query: 163 TLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSI-------PLSFNRFSGLRSLDLS 215 T+ L N + + + + L N + ++ L ++DL Sbjct: 677 TVTLSYNEIQKFPTELFATGSPISTIILSNNLMTSIPENSLKPKDGNYKNTYLLTTIDLR 736 Query: 216 GNRLTGSIPGF---VLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSR------NRVT 266 N+LT F LP LS +D++ N + L S L + NR+ Sbjct: 737 FNKLTSLSDDFRATTLPYLSNMDVSYNCFSSFPTQPLNS-SQLKAFGIRHQRDAEGNRIL 795 Query: 267 GPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTI 318 P I L+ L + N + + L L + N S + Sbjct: 796 RQWPTGITTCPSLIQLQIGSNDIRKV---DEKLTPQLYILDIADNPNISIDV 844 Score = 48.6 bits (114), Expect = 6e-06, Method: Composition-based stats. Identities = 47/253 (18%), Positives = 86/253 (33%), Gaps = 21/253 (8%) Query: 51 GARTEPDEQDAVYDIMRATGNDWAAAIPDVCRGRWHGIECMPDQDNVYHVVSLSFGALSD 110 G + + Y+ + D+ A V G + N+++ S+ S Sbjct: 592 GTNVKLTDLKLDYNQIEEIPEDFCAFTDQV-EGLGFSHNKLKYIPNIFNAKSVYVMG-SV 649 Query: 111 DTAFPTCDPQRSYVSESLTRLKHLKALFFYRCLGRAPQRIPAFLGRLGSSLQTLVLRENG 170 D ++ + +S S+ K + A Q+ P L GS + T++L N Sbjct: 650 DFSYNKIGSEGRNISCSMDDYKGINASTVTLSYNEI-QKFPTELFATGSPISTIILSNNL 708 Query: 171 FLGPIPDELG-------NLTNLKVLDLHKNHLNGSIPLS-FNRFSGLRSLDLSGNRLTGS 222 + L N L +DL N L L ++D+S N + Sbjct: 709 MTSIPENSLKPKDGNYKNTYLLTTIDLRFNKLTSLSDDFRATTLPYLSNMDVSYNCFSSF 768 Query: 223 IPGFV-LPALSVLDLNQ------NLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINR 275 + L + N + P +T+C SLI++ + N + + Sbjct: 769 PTQPLNSSQLKAFGIRHQRDAEGNRILRQWPTGITTCPSLIQLQIGSNDIRKVDEKL--- 825 Query: 276 LNQLVLLDLSYNR 288 QL +LD++ N Sbjct: 826 TPQLYILDIADNP 838 >4AY9-X nrPDB Length = 350 Score = 70.6 bits (171), Expect = 2e-12, Method: Composition-based stats. Identities = 62/304 (20%), Positives = 100/304 (32%), Gaps = 31/304 (10%) Query: 136 ALFFYRCLGRAPQRIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNH- 194 L + P +P L L L + + G +L+ +++ +N Sbjct: 14 FLCQESKVTEIPSDLPRNAIELRFVLTKLRVIQKG-------AFSGFGDLEKIEISQNDV 66 Query: 195 LNGSIPLSFNRFSGLRSLDL-SGNRLTGSIPGFV--LPALSVLDLNQNLLTGPVPPTLTS 251 L F+ L + + N L P LP L L ++ + + Sbjct: 67 LEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLP--DVHK 124 Query: 252 CGSLIK--IDLSRN-RVTGPIPESINRLN-QLVLLDLSYNRLSGPFPSSLQGLNSLQALM 307 SL K +D+ N + S L+ + V+L L+ N + S+ G L L Sbjct: 125 IHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNSAFNG-TQLDELN 183 Query: 308 LKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEI 367 L N +P + F G +IL +S T I L L LR Sbjct: 184 LSDNN-NLEELPNDVFHGASGPVILDISRTRIHSLPSYGLENLKKLRA----------RS 232 Query: 368 PLEFRDVKHLSELR-LNDNSLTGPVPFERDTVW-RMRRKLRLYNNAGLCVNRDSDLDDAF 425 + + L +L L + SLT P W R +L N + + A Sbjct: 233 TYNLKKLPTLEKLVALMEASLTYPSHCCAFANWRRQISELHPICNKSILRQEVDYMTQAR 292 Query: 426 GSKS 429 G +S Sbjct: 293 GQRS 296 >3G06-A nrPDB Length = 622 Score = 67.5 bits (163), Expect = 1e-11, Method: Composition-based stats. Identities = 66/325 (20%), Positives = 104/325 (32%), Gaps = 53/325 (16%) Query: 146 APQRIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLT-----NLKVLDLHKNHLNGSIP 200 AP + ++ + N L L L ++ L + N+L Sbjct: 19 APAEESRGRAAVVQKMRACLNNGNAVLNVGESGLTTLPDCLPAHITTLVIPDNNLTSLPA 78 Query: 201 LSFNRFSGLRSLDLSGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDL 260 L LR+L++SGN+LT + P L L + N LT C + + Sbjct: 79 LP----PELRTLEVSGNQLTSLP--VLPPGLLELSIFSNPLTHLPALPSGLCK----LWI 128 Query: 261 SRNRVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNS-LQALMLKGNTKFSTTIP 319 N++T L L +S N+L+ L S L L N S + Sbjct: 129 FGNQLTSLPVLP----PGLQELSVSDNQLASLP-----ALPSELCKLWAYNNQLTSLPML 179 Query: 320 ENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSE 379 + L L +S+ + + L L N LT L L E Sbjct: 180 PSG------LQELSVSDNQLASLPTLP----SELYKLWAYNNRLTSLPALP----SGLKE 225 Query: 380 LRLNDNSLTGPVPFERDTVWRMRRKLRLYN---------NAGLCVNRDSDL-DDAFGSKS 429 L ++ N LT + M RL + + + N+ + L + S Sbjct: 226 LIVSGNRLTSLPVLPSELKELMVSGNRLTSLPMLPSGLLSLSVYRNQLTRLPESLIHLSS 285 Query: 430 GSTVRLCDAETSRPAPSGTVQHLSR 454 +TV L S T+Q L Sbjct: 286 ETTVNLEGNPLSE----RTLQALRE 306 Score = 55.9 bits (133), Expect = 4e-08, Method: Composition-based stats. Identities = 62/294 (21%), Positives = 94/294 (31%), Gaps = 64/294 (21%) Query: 57 DEQDAVYDIMRAT---GNDWAAAIPDVCRGRWHGIECMPDQDNVY--------HVVSLSF 105 + A + A G +PD C +PD + + +S Sbjct: 32 QKMRACLNNGNAVLNVGESGLTTLPD-CLPAHITTLVIPDNNLTSLPALPPELRTLEVSG 90 Query: 106 GALSDDTAFPTCDPQRSYVSESLTRLKHL-----KALFFYRCLGRAPQRIPAFLGRLGSS 160 L+ P + S S LT L L K F L P L Sbjct: 91 NQLTSLPVLPPGLLELSIFSNPLTHLPALPSGLCKLWIFGNQLTSLP--------VLPPG 142 Query: 161 LQTLVLRENGFLG--PIPDELGNL--------------TNLKVLDLHKNHLNGSI----- 199 LQ L + +N +P EL L + L+ L + N L Sbjct: 143 LQELSVSDNQLASLPALPSELCKLWAYNNQLTSLPMLPSGLQELSVSDNQLASLPTLPSE 202 Query: 200 ----------PLSFNRFSG-LRSLDLSGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPT 248 S L+ L +SGNRLT + L L ++ N LT Sbjct: 203 LYKLWAYNNRLTSLPALPSGLKELIVSGNRLTSLP--VLPSELKELMVSGNRLTSLPMLP 260 Query: 249 LTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNS 302 L+ + + RN++T PES+ L+ ++L N LS +L+ + S Sbjct: 261 ----SGLLSLSVYRNQLTRL-PESLIHLSSETTVNLEGNPLSERTLQALREITS 309 >1XWD-C nrPDB Length = 252 Score = 67.1 bits (162), Expect = 2e-11, Method: Composition-based stats. Identities = 47/228 (20%), Positives = 77/228 (33%), Gaps = 19/228 (8%) Query: 136 ALFFYRCLGRAPQRIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNH- 194 L + P +P L L L + + G +L+ +++ +N Sbjct: 14 FLCQESKVTEIPSDLPRNAIELRFVLTKLRVIQKG-------AFSGFGDLEKIEISQNDV 66 Query: 195 LNGSIPLSFNRFSGLRSLDL-SGNRLTGSIPGFV--LPALSVLDLNQNLLTGPVPPTLTS 251 L F+ L + + N L P LP L L ++ + + Sbjct: 67 LEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLP--DVHK 124 Query: 252 CGSLIK--IDLSRN-RVTGPIPESINRLN-QLVLLDLSYNRLSGPFPSSLQGLNSLQALM 307 SL K +D+ N + S L+ + V+L L+ N + + G L L Sbjct: 125 IHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNG-TQLDELN 183 Query: 308 LKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRV 355 L N +P + F G +IL +S T I L L LR Sbjct: 184 LSDNN-NLEELPNDVFHGASGPVILDISRTRIHSLPSYGLENLKKLRA 230 Score = 57.1 bits (136), Expect = 2e-08, Method: Composition-based stats. Identities = 42/175 (24%), Positives = 66/175 (37%), Gaps = 5/175 (2%) Query: 221 GSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIP-ESINRLNQL 279 IP + L L + G L KI++S+N V I + + L +L Sbjct: 22 TEIPSDLPRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKL 81 Query: 280 VLLDLSY-NRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTN 338 + + N L P + Q L +LQ L L NT + L+ +++ + N N Sbjct: 82 HEIRIEKANNLLYINPEAFQNLPNLQYL-LISNTGIKHLPDVHKIHSLQKVLLDIQDNIN 140 Query: 339 IQGSIPKSLTRLNSLR-VLHLEGNNLTGEIPLEFRDVKHLSELRLNDNSLTGPVP 392 I S L+ +L L N + F L EL L+DN+ +P Sbjct: 141 IHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNG-TQLDELNLSDNNNLEELP 194 Score = 47.1 bits (110), Expect = 2e-05, Method: Composition-based stats. Identities = 37/183 (20%), Positives = 68/183 (37%), Gaps = 12/183 (6%) Query: 236 LNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNR-LSGPFP 294 L Q +P L + I++ ++ + + L +++S N L Sbjct: 15 LCQESKVTEIPSDLPR--NAIELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEA 72 Query: 295 SSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLR 354 L L + ++ I AF+ L NL L++SNT I+ + +++SL+ Sbjct: 73 DVFSNLPKLHEIRIEK-ANNLLYINPEAFQNLPNLQYLLISNTGIKHLPD--VHKIHSLQ 129 Query: 355 V--LHLEGN-NLTGEIPLEFRDVKHLS-ELRLNDNSLTGPVPFERDTVWRMRRKLRLYNN 410 L ++ N N+ F + S L LN N + + +L L +N Sbjct: 130 KVLLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFN--GTQLDELNLSDN 187 Query: 411 AGL 413 L Sbjct: 188 NNL 190 >4PEQ-B nrPDB Length = 456 Score = 66.7 bits (161), Expect = 2e-11, Method: Composition-based stats. Identities = 72/392 (18%), Positives = 113/392 (28%), Gaps = 87/392 (22%) Query: 143 LGRAPQRIPAFLGRLGSSLQTLVLRENGF----LGPIPDELGNLT-NLKVLDLHKNHLNG 197 L + + +SL L LR N + + L + T ++ L L L Sbjct: 35 LTEVRCKDIGSALQANASLTELSLRTNELGDGGVLLVLQGLQSPTCKIQKLSLQNCCLTE 94 Query: 198 S----IPLSFNRFSGLRSLDLSGN-----RLTGSIPGFVLP--ALSVLDLNQNLLTG--- 243 + +P LR L LS N L G + P L L L LT Sbjct: 95 AGCGVLPGVLRSLPTLRELHLSDNPLGDAGLRLLCEGLLDPRCRLEKLQLEYCSLTAASC 154 Query: 244 -PVPPTLTSCGSLIKIDLSRNRVTGPIPESI----------------------------- 273 P+ L + L ++ +S N + +++ Sbjct: 155 EPLAAVLRATRDLKELVVSNNDIGEAGVQALCRGLAESACQLETLKLENCGLTAANCKDL 214 Query: 274 ----NRLNQLVLLDLSYNR-----LSGPFPSSLQGLNSLQALMLKGNTKFSTTIPE--NA 322 L LDL NR L+ P L + L+ L L + E Sbjct: 215 CGIVASQASLKDLDLGSNRLGDAGLAELCPGLLSPSSQLRTLWLWECDLTVSGCRELCRV 274 Query: 323 FKGLKNLMILVLSNTNI-----QGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRDV--- 374 + + L L L+ ++ Q L L L ++ T F + Sbjct: 275 LQAKEALKELSLAGNSLGDEGAQLLCESLLQPGCQLESLWVKSCGFTAACCQHFSSMLTQ 334 Query: 375 -KHLSELRLNDNSL-----------TGPVPFERDTVWRMRRKLRLYNNAGLCVNRDSDLD 422 KHL EL+L+ N L G +W +L + GL Sbjct: 335 NKHLLELQLSSNPLGDAGVHVLCQALGQPGTVLRVLWVGDCELTNSSCGGLAS------- 387 Query: 423 DAFGSKSGSTVRLCDAETSRPAPSGTVQHLSR 454 S S + L + P + L + Sbjct: 388 LLLASPSLRELDLSNNGLGDPGVLQLLGSLEQ 419 Score = 56.3 bits (134), Expect = 3e-08, Method: Composition-based stats. Identities = 59/286 (20%), Positives = 91/286 (31%), Gaps = 38/286 (13%) Query: 130 RLKHLKALFFYRCLGRAPQRIPAFLGRLGSSLQTLVLRENGFLGPIPDELGN-----LTN 184 R + K Y L A A + R L+ LV+ N L Sbjct: 136 RCRLEKLQLEYCSLTAASCEPLAAVLRATRDLKELVVSNNDIGEAGVQALCRGLAESACQ 195 Query: 185 LKVLDLHKNHLNGS----IPLSFNRFSGLRSLDLSGNRL-----TGSIPGFVLPA--LSV 233 L+ L L L + + + L+ LDL NRL PG + P+ L Sbjct: 196 LETLKLENCGLTAANCKDLCGIVASQASLKDLDLGSNRLGDAGLAELCPGLLSPSSQLRT 255 Query: 234 LDLNQNLLTGP----VPPTLTSCGSLIKIDLSRNRVTG-----PIPESINRLNQLVLLDL 284 L L + LT + L + +L ++ L+ N + + QL L + Sbjct: 256 LWLWECDLTVSGCRELCRVLQAKEALKELSLAGNSLGDEGAQLLCESLLQPGCQLESLWV 315 Query: 285 SYNRLSGP----FPSSLQGLNSLQALMLKGNTKFSTTIP---ENAFKGLKNLMILVLSNT 337 + F S L L L L N + + + L +L + + Sbjct: 316 KSCGFTAACCQHFSSMLTQNKHLLELQLSSNPLGDAGVHVLCQALGQPGTVLRVLWVGDC 375 Query: 338 NIQGSIPKSLTRL----NSLRVLHLEGNNLTGEIPLEFRDVKHLSE 379 + S L L SLR L L N L P + + L + Sbjct: 376 ELTNSSCGGLASLLLASPSLRELDLSNNGLGD--PGVLQLLGSLEQ 419 >6J5T-G nrPDB Length = 852 Score = 65.6 bits (158), Expect = 4e-11, Method: Composition-based stats. Identities = 57/295 (19%), Positives = 98/295 (33%), Gaps = 24/295 (8%) Query: 59 QDAVYDIMRATGNDWAAAIPDVCRGRWHGIECMPDQDNVYHVVSLSFGALSDDTAFPTCD 118 +D V DI + D + P+ R GI D+ + V+ + T + Sbjct: 492 RDLVIDIAK---KDSFSN-PEGLNCRHLGISGNFDEKQIK--VNHKLRGVVSTTKTGEVN 545 Query: 119 PQRSYVSESLTRLKHLKALFFYRCLGRAPQRIPAFLGRLGSSLQTLVLRENGFLGPIPDE 178 S +++ T K+L+ L + + AP L L L L P Sbjct: 546 KLNSDLAKKFTDCKYLRVLDISKSIFDAPLSEILDEIASLQHLACLSLSNTHPLIQFPRS 605 Query: 179 LGNLTNLKVLDLHKNH-LNGSIPLSFNRFSGLRSLDLSGNRLTGSIPGFV--LPALSVL- 234 + +L NL++LD L P F L LD++ P + L L VL Sbjct: 606 MEDLHNLQILDASYCQNLKQLQPCIVL-FKKLLVLDMTNCGSLECFPKGIGSLVKLEVLL 664 Query: 235 ----DLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLL-DLSYNRL 289 + N + + +L K+ LS R E ++ L L L +S N Sbjct: 665 GFKPARSNNGCKLS---EVKNLTNLRKLGLSLTRGDQIEEEELDSLINLSKLMSISINCY 721 Query: 290 SGPFPSSLQGLNSLQ---ALMLKGNTKFSTTIPENAFKG--LKNLMILVLSNTNI 339 + +++L L + + L L + + + N+ Sbjct: 722 DSYGDDLITKIDALTPPHQLHELSLQFYPGKSSPSWLSPHKLPMLRYMSICSGNL 776 Score = 50.2 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 48/223 (21%), Positives = 76/223 (34%), Gaps = 42/223 (18%) Query: 195 LNGSIPLSFNRFSGL--RSLDLSGN------RLTGSIPGFVLPALSVLDLNQNLLTGPVP 246 ++ + SF+ GL R L +SGN ++ + G V + N L + Sbjct: 496 IDIAKKDSFSNPEGLNCRHLGISGNFDEKQIKVNHKLRGVVSTTKTG---EVNKLNSDLA 552 Query: 247 PTLTSCGSLIKIDLSRN---RVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSL 303 T C L +D+S++ I + I L L L LS FP S++ L++L Sbjct: 553 KKFTDCKYLRVLDISKSIFDAPLSEILDEIASLQHLACLSLSNTHPLIQFPRSMEDLHNL 612 Query: 304 QALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKS----------------- 346 Q L P K L++L ++N PK Sbjct: 613 QILDASYCQNLKQLQPCIVL--FKKLLVLDMTNCGSLECFPKGIGSLVKLEVLLGFKPAR 670 Query: 347 ---------LTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSEL 380 + L +LR L L E + +LS+L Sbjct: 671 SNNGCKLSEVKNLTNLRKLGLSLTRGDQIEEEELDSLINLSKL 713 Score = 42.1 bits (97), Expect = 5e-04, Method: Composition-based stats. Identities = 30/192 (15%), Positives = 64/192 (33%), Gaps = 24/192 (12%) Query: 263 NRVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENA 322 N++ + + L +LD+S + P L + SLQ L Sbjct: 545 NKLNSDLAKKFTDCKYLRVLDISKSIFDAPLSEILDEIASLQHLAC-------------- 590 Query: 323 FKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRL 382 L LSNT+ P+S+ L++L++L ++ K L L + Sbjct: 591 ---------LSLSNTHPLIQFPRSMEDLHNLQILDASYCQNLKQLQPCIVLFKKLLVLDM 641 Query: 383 NDNSLTGPVPFERDTVWRMRRKLRLYNNAGLCVNRDSDLDDAFGSKSGSTVRLCDAETSR 442 + P ++ ++ L + S++ + + + L + Sbjct: 642 TNCGSLECFPKGIGSLVKLEVLLGFKPARSNNGCKLSEVKNLTNLRKLG-LSLTRGDQIE 700 Query: 443 PAPSGTVQHLSR 454 ++ +LS+ Sbjct: 701 EEELDSLINLSK 712 >2BNH-A nrPDB Length = 457 Score = 59.4 bits (142), Expect = 3e-09, Method: Composition-based stats. Identities = 56/246 (22%), Positives = 81/246 (32%), Gaps = 35/246 (14%) Query: 207 SGLRSLDLSGNRLTGSIPGFVLPALSV-------LDLNQNLLT----GPVPPTLTSCGSL 255 L L L N L + VL L L L LT G +P TL S +L Sbjct: 52 PSLTELCLRTNELGDAGVHLVLQGLQSPTCKIQKLSLQNCSLTEAGCGVLPSTLRSLPTL 111 Query: 256 IKIDLSRNRVTG-----PIPESINRLNQLVLLDLSYNRLSG----PFPSSLQGLNSLQAL 306 ++ LS N + ++ L L L Y RL+ P S L+ +L+ L Sbjct: 112 RELHLSDNPLGDAGLRLLCEGLLDPQCHLEKLQLEYCRLTAASCEPLASVLRATRALKEL 171 Query: 307 MLKGNTKFS---TTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRL----NSLRVLHLE 359 + N + + L L L N + + K L + SLR L L Sbjct: 172 TVSNNDIGEAGARVLGQGLADSACQLETLRLENCGLTPANCKDLCGIVASQASLRELDLG 231 Query: 360 GNNL-----TGEIPLEFRDVKHLSELRLNDNSLTGPVPFERDTVWRMRRKLRLYNNAGLC 414 N L P L L L + +T + V + + L+ L Sbjct: 232 SNGLGDAGIAELCPGLLSPASRLKTLWLWECDITASGCRDLCRVLQAKETLK---ELSLA 288 Query: 415 VNRDSD 420 N+ D Sbjct: 289 GNKLGD 294 Score = 58.6 bits (140), Expect = 6e-09, Method: Composition-based stats. Identities = 67/368 (18%), Positives = 107/368 (29%), Gaps = 73/368 (19%) Query: 160 SLQTLVLRENGF----LGPIPDELGNLT-NLKVLDLHKNHLNGS----IPLSFNRFSGLR 210 SL L LR N + + L + T ++ L L L + +P + LR Sbjct: 53 SLTELCLRTNELGDAGVHLVLQGLQSPTCKIQKLSLQNCSLTEAGCGVLPSTLRSLPTLR 112 Query: 211 SLDLSGN-----RLTGSIPGFVLPA--LSVLDLNQNLLTG----PVPPTLTSCGSLIKID 259 L LS N L G + P L L L LT P+ L + +L ++ Sbjct: 113 ELHLSDNPLGDAGLRLLCEGLLDPQCHLEKLQLEYCRLTAASCEPLASVLRATRALKELT 172 Query: 260 LSRNRVTG----------------PIPESINRLN-----------------QLVLLDLSY 286 +S N + + L LDL Sbjct: 173 VSNNDIGEAGARVLGQGLADSACQLETLRLENCGLTPANCKDLCGIVASQASLRELDLGS 232 Query: 287 NRL-----SGPFPSSLQGLNSLQALMLKGNTKFSTTIPE--NAFKGLKNLMILVLSNTNI 339 N L + P L + L+ L L ++ + + + L L L+ + Sbjct: 233 NGLGDAGIAELCPGLLSPASRLKTLWLWECDITASGCRDLCRVLQAKETLKELSLAGNKL 292 Query: 340 QG-----SIPKSLTRLNSLRVLHLEGNNLTGEI----PLEFRDVKHLSELRLNDNSLTGP 390 L L L ++ +LT L KHL EL+L+ N L Sbjct: 293 GDEGARLLCESLLQPGCQLESLWVKSCSLTAACCQHVSLMLTQNKHLLELQLSSNKLGDS 352 Query: 391 ----VPFERDTVWRMRRKLRLYNNAGLCVNRDSDLDDAFGSKSGSTVRLCDAETSRPAPS 446 + R L L + S ++S + L + P Sbjct: 353 GIQELCQALSQPGTTLRVLCLGDCEVTNSGCSSLASLLLANRSLRELDLSNNCVGDPGVL 412 Query: 447 GTVQHLSR 454 + L + Sbjct: 413 QLLGSLEQ 420 Score = 49.8 bits (117), Expect = 3e-06, Method: Composition-based stats. Identities = 56/266 (21%), Positives = 83/266 (31%), Gaps = 37/266 (13%) Query: 133 HLKALFFYRCLGRAPQRIPAFLGRLGSS-LQTLVLRENGF----LGPIPDELGNLT-NLK 186 HL+ L C A P + L+ L + N + L + L+ Sbjct: 139 HLEKLQLEYCRLTAASCEPLASVLRATRALKELTVSNNDIGEAGARVLGQGLADSACQLE 198 Query: 187 VLDLHKNHLNGS----IPLSFNRFSGLRSLDLSGNRL-----TGSIPGFVLP--ALSVLD 235 L L L + + + LR LDL N L PG + P L L Sbjct: 199 TLRLENCGLTPANCKDLCGIVASQASLRELDLGSNGLGDAGIAELCPGLLSPASRLKTLW 258 Query: 236 LNQNLLTGPVPPTLTSC----GSLIKIDLSRNRVTG-----PIPESINRLNQLVLLDLSY 286 L + +T L +L ++ L+ N++ + QL L + Sbjct: 259 LWECDITASGCRDLCRVLQAKETLKELSLAGNKLGDEGARLLCESLLQPGCQLESLWVKS 318 Query: 287 NRLSGP----FPSSLQGLNSLQALMLKGNTKFSTTIPE---NAFKGLKNLMILVLSNTNI 339 L+ L L L L N + I E + L +L L + + Sbjct: 319 CSLTAACCQHVSLMLTQNKHLLELQLSSNKLGDSGIQELCQALSQPGTTLRVLCLGDCEV 378 Query: 340 QGSIPKSLTRL----NSLRVLHLEGN 361 S SL L SLR L L N Sbjct: 379 TNSGCSSLASLLLANRSLRELDLSNN 404 Score = 44.4 bits (103), Expect = 1e-04, Method: Composition-based stats. Identities = 48/239 (20%), Positives = 77/239 (32%), Gaps = 33/239 (13%) Query: 148 QRIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLT----NLKVLDLHKNHLNG-----S 198 + + L L+TL L G +L + +L+ LDL N L Sbjct: 184 RVLGQGLADSACQLETLRLENCGLTPANCKDLCGIVASQASLRELDLGSNGLGDAGIAEL 243 Query: 199 IPLSFNRFSGLRSLDLSGNRLTGSIPGFVL------PALSVLDLNQNLL-----TGPVPP 247 P + S L++L L +T S + L L L N L Sbjct: 244 CPGLLSPASRLKTLWLWECDITASGCRDLCRVLQAKETLKELSLAGNKLGDEGARLLCES 303 Query: 248 TLTSCGSLIKIDLSRNRVTGPI----PESINRLNQLVLLDLSYNRL-----SGPFPSSLQ 298 L L + + +T + + L+ L LS N+L + Q Sbjct: 304 LLQPGCQLESLWVKSCSLTAACCQHVSLMLTQNKHLLELQLSSNKLGDSGIQELCQALSQ 363 Query: 299 GLNSLQALMLKGNTKFST--TIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRV 355 +L+ L L ++ + + ++L L LSN + P L L SL Sbjct: 364 PGTTLRVLCLGDCEVTNSGCSSLASLLLANRSLRELDLSNNCVGD--PGVLQLLGSLEQ 420 Score = 43.2 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 40/181 (22%), Positives = 68/181 (37%), Gaps = 22/181 (12%) Query: 258 IDLSRNRVTGP-IPESINRLNQLVLLDLSYNRLSGPF----PSSLQGLNSLQALMLKGNT 312 +D+ +++ E + L Q ++ L L+ S+L+ SL L L+ N Sbjct: 4 LDIHCEQLSDARWTELLPLLQQYEVVRLDDCGLTEEHCKDIGSALRANPSLTELCLRTN- 62 Query: 313 KFSTTIPENAFKGLKN----LMILVLSNTNIQ----GSIPKSLTRLNSLRVLHLEGNNLT 364 + +GL++ + L L N ++ G +P +L L +LR LHL N L Sbjct: 63 ELGDAGVHLVLQGLQSPTCKIQKLSLQNCSLTEAGCGVLPSTLRSLPTLRELHLSDNPLG 122 Query: 365 G-----EIPLEFRDVKHLSELRLNDNSLTGPVPFERDTVWRMRRKLRLYNNAGLCVNRDS 419 HL +L+L LT +V R R L+ + N Sbjct: 123 DAGLRLLCEGLLDPQCHLEKLQLEYCRLTAASCEPLASVLRATRALK---ELTVSNNDIG 179 Query: 420 D 420 + Sbjct: 180 E 180 Score = 33.6 bits (75), Expect = 0.19, Method: Composition-based stats. Identities = 40/174 (22%), Positives = 60/174 (34%), Gaps = 23/174 (13%) Query: 128 LTRLKHLKALFFYRC-LGRAPQRIPAFLGRLGSSLQTLVLRENGF-----LGPIPDELGN 181 L+ LK L+ + C + + R + + +L+ L L N L Sbjct: 248 LSPASRLKTLWLWECDITASGCRDLCRVLQAKETLKELSLAGNKLGDEGARLLCESLLQP 307 Query: 182 LTNLKVLDLHKNHLN----GSIPLSFNRFSGLRSLDLSGNRLTGSIPGFVLPA------- 230 L+ L + L + L + L L LS N+L S + A Sbjct: 308 GCQLESLWVKSCSLTAACCQHVSLMLTQNKHLLELQLSSNKLGDSGIQELCQALSQPGTT 367 Query: 231 LSVLDLNQNLLTGPVPPTLTSC----GSLIKIDLSRNRVTGPIPESINRLNQLV 280 L VL L +T +L S SL ++DLS N V P + L L Sbjct: 368 LRVLCLGDCEVTNSGCSSLASLLLANRSLRELDLSNNCVGD--PGVLQLLGSLE 419 >5YXM-A nrPDB Length = 203 Score = 59.4 bits (142), Expect = 3e-09, Method: Composition-based stats. Identities = 32/143 (22%), Positives = 58/143 (40%), Gaps = 12/143 (8%) Query: 200 PLSFNRFSGLRSLDLSGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKID 259 + + + L LS N + + L +L L +NL+ + +L ++ Sbjct: 46 DATLSTLKACKHLALSTNNIEKISSLSGMENLRILSLGRNLIKKIENLDAVA-DTLEELW 104 Query: 260 LSRNRVTGPIPESINRLNQLVLLDLSYNRLSGP-FPSSLQGLNSLQALMLKGNTKFSTTI 318 +S N++ I +L L +L +S N+++ L L+ L+ L+L GN ++ Sbjct: 105 ISYNQIASL--SGIEKLVNLRVLYMSNNKITNWGEIDKLAALDKLEDLLLAGNPLYNDYK 162 Query: 319 PENA--------FKGLKNLMILV 333 NA K L NL L Sbjct: 163 ENNATSEYRIEVVKRLPNLKKLD 185 Score = 41.7 bits (96), Expect = 8e-04, Method: Composition-based stats. Identities = 23/117 (19%), Positives = 43/117 (36%), Gaps = 7/117 (5%) Query: 294 PSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSL 353 ++L L + + L L N ++ G++NL IL L I+ L Sbjct: 46 DATLSTLKACKHLALSTNNIEKI----SSLSGMENLRILSLGRNLIKKIENLDAVADT-L 100 Query: 354 RVLHLEGNNLTGEIPLEFRDVKHLSELRLNDNSLTGPVPFERDTVWRMRRKLRLYNN 410 L + N + +E + +L L +++N +T ++ L L N Sbjct: 101 EELWISYNQIASLSGIEK--LVNLRVLYMSNNKITNWGEIDKLAALDKLEDLLLAGN 155 Score = 38.2 bits (87), Expect = 0.008, Method: Composition-based stats. Identities = 27/136 (19%), Positives = 48/136 (35%), Gaps = 19/136 (13%) Query: 125 SESLTRLKHLKALFFYRCLGRAPQRIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTN 184 SL+ +++L+ L R L + + + A + +L+ L + N + L N Sbjct: 68 ISSLSGMENLRILSLGRNLIKKIENLDA----VADTLEELWISYNQI--ASLSGIEKLVN 121 Query: 185 LKVLDLHKNHL-NGSIPLSFNRFSGLRSLDLSGNRLTGSIPGFVLPALSVLDLNQNLLTG 243 L+VL + N + N L L L+GN L N + Sbjct: 122 LRVLYMSNNKITNWGEIDKLAALDKLEDLLLAGNPLYN------------DYKENNATSE 169 Query: 244 PVPPTLTSCGSLIKID 259 + +L K+D Sbjct: 170 YRIEVVKRLPNLKKLD 185 >3G04-C nrPDB Length = 239 Score = 57.9 bits (138), Expect = 1e-08, Method: Composition-based stats. Identities = 49/207 (23%), Positives = 79/207 (38%), Gaps = 14/207 (6%) Query: 157 LGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNH-LNGSIPLSFNRFSGLRSLDLS 215 L S QTL L E NL N+ + + + L SF S + +++ Sbjct: 29 LPPSTQTLKLIETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIR 88 Query: 216 GNR-LTGSIPGFV--LPALSVLDLNQNLLTGPVP-PTLTSCGSLIKIDLSRNR-VTGPIP 270 R LT P + LP L L + L + S ++++ N +T Sbjct: 89 NTRNLTYIDPDALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPV 148 Query: 271 ESINRL-NQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGL--- 326 + L N+ + L L N + + G L A+ L N + T I ++AF G+ Sbjct: 149 NAFQGLCNETLTLKLYNNGFTSVQGYAFNG-TKLDAVYLNKNK-YLTVIDKDAFGGVYSG 206 Query: 327 KNLMILVLSNTNIQGSIPKSLTRLNSL 353 +L L +S T++ K L L L Sbjct: 207 PSL--LDVSQTSVTALPSKGLEHLKEL 231 >3CVR-A nrPDB Length = 571 Score = 57.5 bits (137), Expect = 1e-08, Method: Composition-based stats. Identities = 40/219 (18%), Positives = 74/219 (33%), Gaps = 27/219 (12%) Query: 135 KALFFYRCLGRAPQRIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLT-NLKVLDLHKN 193 + L P +P + L + L+ L L +L+ LD N Sbjct: 63 ELQLNRLNLSSLPDNLPPQITVLEITQNALI------------SLPELPASLEYLDACDN 110 Query: 194 HLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCG 253 L+ L L+ LD+ N+LT + L ++ + N LT Sbjct: 111 RLSTLPELPA----SLKHLDVDNNQLTMLP--ELPALLEYINADNNQLTMLPELP----T 160 Query: 254 SLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTK 313 SL + + N++T L LD+S N L ++ +S + + + Sbjct: 161 SLEVLSVRNNQLTFLPELP----ESLEALDVSTNLLESLPAVPVRNHHSEETEIFFRCRE 216 Query: 314 FSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNS 352 T L ++L + + I +SL++ + Sbjct: 217 NRITHIPENILSLDPTCTIILEDNPLSSRIRESLSQQTA 255 Score = 44.8 bits (104), Expect = 8e-05, Method: Composition-based stats. Identities = 34/177 (19%), Positives = 56/177 (31%), Gaps = 25/177 (14%) Query: 215 SGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESIN 274 + N + ++ S L LN+ L+ P L + +++++N + Sbjct: 45 NRNEAVSLLKECLINQFSELQLNRLNLSSL-PDNLP--PQITVLEITQNALISLPELP-- 99 Query: 275 RLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVL 334 L LD NRLS + SL+ L + N L + Sbjct: 100 --ASLEYLDACDNRLSTLP----ELPASLKHLDVDNNQLTMLPELPAL------LEYINA 147 Query: 335 SNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLNDNSLTGPV 391 N + SL VL + N LT L + L L ++ N L Sbjct: 148 DNNQLTMLPELP----TSLEVLSVRNNQLTFLPELP----ESLEALDVSTNLLESLP 196 >5KH1-A nrPDB Length = 591 Score = 57.1 bits (136), Expect = 2e-08, Method: Composition-based stats. Identities = 53/219 (24%), Positives = 81/219 (36%), Gaps = 22/219 (10%) Query: 86 HGIECMPDQDNVYHVVSLSFGALSDDTAFPTCDPQRSYVSESLTRLKHL-KALFFYRCLG 144 G+ +P+ +++S LS + P Q + L L L + L Sbjct: 77 LGLTTLPEIPPGIKSINISKNNLSLISPLPASLTQLNVSYNRLIELPALPQGLKLLNASH 136 Query: 145 RAPQRIPAFLGRLGSSLQTLVLRENGF-LGPIPDELGNLTNLKVLDLHKNHLNGSIPLSF 203 +P L SL+ L + N P+ EL L+ LD+ N L PL F Sbjct: 137 NQLITLPT----LPISLKELHVSNNQLCSLPVLPEL-----LETLDVSCNGLAVLPPLPF 187 Query: 204 NRFSGLRSLDLSGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRN 263 L+ + GN L+ P + + + N+LT +L N Sbjct: 188 ----SLQEISAIGNLLSELPP--LPHNIHSIWAIDNMLTDIPYLP----ENLRNGYFDIN 237 Query: 264 RVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNS 302 +++ PESI L +D+S N LS SLQ L S Sbjct: 238 QISHI-PESILNLRNECSIDISDNPLSSHALQSLQRLTS 275 Score = 52.5 bits (124), Expect = 5e-07, Method: Composition-based stats. Identities = 52/287 (18%), Positives = 94/287 (32%), Gaps = 41/287 (14%) Query: 89 ECMPDQDNVYHVVSLSFGALSDDTAFPTCDPQRSYVSESLTRL----KHLKALFFYRCLG 144 E M +N + ++S SF S DT+ + + R+ + + CL Sbjct: 7 EFMLPTNNNHRLISNSFSTYSIDTSRAYENYLTHWTEWKNNRIQEEQRDIAFQRLVSCLQ 66 Query: 145 RAPQRIPAFLGRL------GSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGS 198 + L ++++ + +N P +L L++ N L Sbjct: 67 NQETNLDLSELGLTTLPEIPPGIKSINISKNNLSLISPLP----ASLTQLNVSYNRLIEL 122 Query: 199 IPLSFNRFSGLRSLDLSGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKI 258 L GL+ L+ S N+L + +L L ++ N L L L + Sbjct: 123 PALP----QGLKLLNASHNQLITLPT--LPISLKELHVSNNQLCSLP--VLPEL--LETL 172 Query: 259 DLSRNRVTGPIPESINRLNQLVLLDLSYNRLSGPFP------------SSLQGLNSL-QA 305 D+S N + P L + N LS P + L + L + Sbjct: 173 DVSCNGLAVLPPLPF----SLQEISAIGNLLSELPPLPHNIHSIWAIDNMLTDIPYLPEN 228 Query: 306 LMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNS 352 L + + L+N + +S+ + +SL RL S Sbjct: 229 LRNGYFDINQISHIPESILNLRNECSIDISDNPLSSHALQSLQRLTS 275 Score = 44.4 bits (103), Expect = 1e-04, Method: Composition-based stats. Identities = 33/164 (20%), Positives = 51/164 (31%), Gaps = 30/164 (18%) Query: 237 NQNLLTGPVPPT----LTSCGSLIK--IDLSRNRVTGPIPESINRLNQLVLLDLSYNRLS 290 N + L SC + +DLS +T + +++S N LS Sbjct: 45 KNNRIQEEQRDIAFQRLVSCLQNQETNLDLSELGLTTLPEIP----PGIKSINISKNNLS 100 Query: 291 GPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKN-LMILVLSNTNIQGSIPKSLTR 349 P SL L + N L L +L S+ + + Sbjct: 101 LISP----LPASLTQLNVSYNRLIE-------LPALPQGLKLLNASHNQLITLPTLPI-- 147 Query: 350 LNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLNDNSLTGPVPF 393 SL+ LH+ N L L + L L ++ N L P Sbjct: 148 --SLKELHVSNNQLCSLPVLP----ELLETLDVSCNGLAVLPPL 185 >2Q4G-W nrPDB Length = 461 Score = 56.7 bits (135), Expect = 3e-08, Method: Composition-based stats. Identities = 61/298 (20%), Positives = 96/298 (32%), Gaps = 42/298 (14%) Query: 161 LQTLVLRENGFLGP-IPDELGNLTNLKVLDLHKNHLNGSIPLSFNRF----SGLRSLDLS 215 +Q+L ++ + L L +V+ L L + + L L+L Sbjct: 5 IQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNLR 64 Query: 216 GNRLTGSIPGFVLPALSV-------LDLNQNLLTG----PVPPTLTSCGSLIKIDLSRNR 264 N L VL L L L LTG + TL + +L ++ LS N Sbjct: 65 SNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNL 124 Query: 265 VTG-----PIPESINRLNQLVLLDLSYNRLSG----PFPSSLQGLNSLQALMLKGNTKFS 315 + ++ +L L L Y LS P S L+ + L + N + Sbjct: 125 LGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNND-IN 183 Query: 316 TTIPENAFKGLKN----LMILVLSNTNIQGSIPKSLTRL----NSLRVLHLEGNNL---- 363 +GLK+ L L L + + + L + SLR L L N L Sbjct: 184 EAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVG 243 Query: 364 -TGEIPLEFRDVKHLSELRLNDNSLTGPVPFERDTVWRMRRKLRLYNNAGLCVNRDSD 420 P L L + + +T + V R + L+ L N D Sbjct: 244 MAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLK---ELSLAGNELGD 298 Score = 40.9 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 54/309 (17%), Positives = 88/309 (28%), Gaps = 66/309 (21%) Query: 123 YVSESLTRLKHLKALFFYRCL--GRAPQRIPAFLGRLGSSLQTLVLRENGFL----GPIP 176 +S +L L L+ L L Q + L L+ L L P+ Sbjct: 104 VLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLA 163 Query: 177 DELGNLTNLKVLDLHKNHLNG-----SIPLSFNRFSGLRSLDL------SGNRLTGSIPG 225 L + K L + N +N + L +L L S N Sbjct: 164 SVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIV 223 Query: 226 FVLPALSVLDLNQNLL-----TGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINRL---- 276 +L L L N L P L L + + +T + R+ Sbjct: 224 ASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAK 283 Query: 277 NQLVLLDLSYNRL-----SGPFPSSLQGLNSLQALMLKGNTKFSTTIPE--NAFKGLKNL 329 L L L+ N L + L+ L++L +K + + + + L Sbjct: 284 ESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFL 343 Query: 330 MILVLSNTNIQG---------------------------------SIPKSLTRLNSLRVL 356 + L +SN ++ S+ +L +SLR L Sbjct: 344 LELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLREL 403 Query: 357 HLEGNNLTG 365 L N L Sbjct: 404 DLSNNCLGD 412 >1JL5-A nrPDB Length = 454 Score = 55.2 bits (131), Expect = 7e-08, Method: Composition-based stats. Identities = 66/366 (18%), Positives = 128/366 (34%), Gaps = 50/366 (13%) Query: 14 LSIVSPLVRSFTVITSDSTAPSALIDGPQ--TGFTMTNDGARTEPDEQDAVYDIMRATGN 71 L+ + L +S + D+ AL D P ++N+ P+ Q++ + + N Sbjct: 103 LTELPELPQSLKSLLVDNNNLKALSDLPPLLEYLGVSNNQLEKLPELQNSSFLKIIDVDN 162 Query: 72 DWAAAIPDVCRGRWHGIECMPDQDNVYHVVSLSFGALSDDTAFPTCDPQRSYVSESLTRL 131 + +PD+ + + + +L F + SL +L Sbjct: 163 NSLKKLPDLPPSLEFIAAGNNQLEELPELQNLPFL------------TAIYADNNSLKKL 210 Query: 132 KHLKALFFYRCLGRAPQRIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLH 191 L G L L T + +N L +PD +L+ L++ Sbjct: 211 PDLPLSLESIVAGNNILEELPELQNLP--FLTTIYADNNLLKTLPDL---PPSLEALNVR 265 Query: 192 KNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTS 251 N+L L L LD+S N +G + P L L+ + N + Sbjct: 266 DNYLTDLPELP----QSLTFLDVSENIFSGL--SELPPNLYYLNASSNEIRSLCDLP--- 316 Query: 252 CGSLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGN 311 SL ++++S N++ +L L S+N L+ + +L+ L ++ N Sbjct: 317 -PSLEELNVSNNKLIELPALP----PRLERLIASFNHLAEVP----ELPQNLKQLHVEYN 367 Query: 312 TKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTG--EIPL 369 + + L+ N+++ +L+ LH+E N L +IP Sbjct: 368 PLREFPDIPESVEDLR-------MNSHLAEVPELP----QNLKQLHVETNPLREFPDIPE 416 Query: 370 EFRDVK 375 D++ Sbjct: 417 SVEDLR 422 Score = 52.9 bits (125), Expect = 4e-07, Method: Composition-based stats. Identities = 51/255 (20%), Positives = 87/255 (34%), Gaps = 32/255 (12%) Query: 156 RLGSSLQTLVLRENGFLGPIPDELGNLT-NLKVLDLHKNHLNGSIPLSFNRFSGLRSLDL 214 L L++LV N EL L +LK L + N+L L L L + Sbjct: 88 ELPPHLESLVASCNSL-----TELPELPQSLKSLLVDNNNLKALSDLP----PLLEYLGV 138 Query: 215 SGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESIN 274 S N+L L ++D++ N L SL I N++ + Sbjct: 139 SNNQLEKLPELQNSSFLKIIDVDNNSLKKLPDLP----PSLEFIAAGNNQLEELPE--LQ 192 Query: 275 RLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVL 334 L L + N L L SL++++ N +PE + L L + Sbjct: 193 NLPFLTAIYADNNSLKKLPDLPL----SLESIVAGNN--ILEELPE--LQNLPFLTTIYA 244 Query: 335 SNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLNDNSLTGPVPFE 394 N ++ SL L++ N LT L + L+ L +++N +G Sbjct: 245 DNNLLKTLPDLP----PSLEALNVRDNYLTDLPELP----QSLTFLDVSENIFSGLSELP 296 Query: 395 RDTVWRMRRKLRLYN 409 + + + + Sbjct: 297 PNLYYLNASSNEIRS 311 >1DCE-A nrPDB Length = 567 Score = 54.4 bits (129), Expect = 1e-07, Method: Composition-based stats. Identities = 35/159 (22%), Positives = 51/159 (32%), Gaps = 12/159 (7%) Query: 110 DDTAFPTCDPQRSYVSESL--TRLKHLKALFFYRCLGRAPQRIPAFLGRLGSSLQTLVLR 167 D + Q +++ R +L L L + ++ R+ L L Sbjct: 396 DPLLYEKETLQYFSTLKAVDPMRAAYLDDLRSKFLLENSVLKMEYADVRV------LHLA 449 Query: 168 ENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPGFV 227 + L L + LDL N L P + L L S N L Sbjct: 450 HKDLT--VLCHLEQLLLVTHLDLSHNRLRALPP-ALAALRCLEVLQASDNALENVDGVAN 506 Query: 228 LPALSVLDLNQNLLTGPVP-PTLTSCGSLIKIDLSRNRV 265 LP L L L N L L SC L+ ++L N + Sbjct: 507 LPRLQELLLCNNRLQQSAAIQPLVSCPRLVLLNLQGNSL 545 Score = 53.3 bits (126), Expect = 2e-07, Method: Composition-based stats. Identities = 31/116 (26%), Positives = 49/116 (42%), Gaps = 8/116 (6%) Query: 252 CGSLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGN 311 + + L+ +T + +L + LDLS+NRL P +L L L+ L N Sbjct: 440 YADVRVLHLAHKDLTVLC--HLEQLLLVTHLDLSHNRLRALPP-ALAALRCLEVLQASDN 496 Query: 312 TKFSTTIPENAFKGLKNLMILVLSNTNIQGSIP-KSLTRLNSLRVLHLEGNNLTGE 366 + L L L+L N +Q S + L L +L+L+GN+L E Sbjct: 497 ALENVDG----VANLPRLQELLLCNNRLQQSAAIQPLVSCPRLVLLNLQGNSLCQE 548 Score = 48.2 bits (113), Expect = 8e-06, Method: Composition-based stats. Identities = 31/148 (20%), Positives = 48/148 (32%), Gaps = 14/148 (9%) Query: 241 LTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGL 300 L P L L N V + +L L++ L+ L+ L Sbjct: 411 LKAVDPMRAAYLDDLRSKFLLENSVLKMEYADV------RVLHLAHKDLTVL--CHLEQL 462 Query: 301 NSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEG 360 + L L N + A L+ L +L S+ ++ + L L+ L L Sbjct: 463 LLVTHLDLSHNRLRAL---PPALAALRCLEVLQASDNALENV--DGVANLPRLQELLLCN 517 Query: 361 NNLTGEIPLE-FRDVKHLSELRLNDNSL 387 N L ++ L L L NSL Sbjct: 518 NRLQQSAAIQPLVSCPRLVLLNLQGNSL 545 Score = 39.8 bits (91), Expect = 0.003, Method: Composition-based stats. Identities = 22/101 (21%), Positives = 33/101 (32%), Gaps = 10/101 (9%) Query: 354 RVLHLEGNNLTGEIPLEFRDVKHLSELRLNDNSLTGPVPFERDTVWRMRRKLRLYNNAGL 413 RVLHL +LT LE + ++ L L+ N L P LR Sbjct: 444 RVLHLAHKDLTVLCHLE--QLLLVTHLDLSHNRLRALPP--------ALAALRCLEVLQA 493 Query: 414 CVNRDSDLDDAFGSKSGSTVRLCDAETSRPAPSGTVQHLSR 454 N ++D + LC+ + A + R Sbjct: 494 SDNALENVDGVANLPRLQELLLCNNRLQQSAAIQPLVSCPR 534 >3TSR-E nrPDB Length = 457 Score = 53.3 bits (126), Expect = 3e-07, Method: Composition-based stats. Identities = 54/246 (21%), Positives = 77/246 (31%), Gaps = 35/246 (14%) Query: 207 SGLRSLDLSGNRLTGSIPGFVLP-------ALSVLDLNQNLLT----GPVPPTLTSCGSL 255 L L L N L G VL + L L LT G +P L S +L Sbjct: 52 PALTELSLRTNELGDGGVGLVLQGLQNPTCKIQKLSLQNCGLTEAGCGILPGMLRSLSTL 111 Query: 256 IKIDLSRN-----RVTGPIPESINRLNQLVLLDLSYNRLSG----PFPSSLQGLNSLQAL 306 ++ L+ N + + +L L L Y L+ P S L+ + L Sbjct: 112 RELHLNDNPMGDAGLKLLCEGLQDPQCRLEKLQLEYCNLTATSCEPLASVLRVKADFKEL 171 Query: 307 MLKGNT---KFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSL----TRLNSLRVLHLE 359 +L N + + L L L N I + K L SL+ L L Sbjct: 172 VLSNNDLHEPGVRILCQGLKDSACQLESLKLENCGITAANCKDLCDVVASKASLQELDLS 231 Query: 360 GNNL-----TGEIPLEFRDVKHLSELRLNDNSLTGPVPFERDTVWRMRRKLRLYNNAGLC 414 N L P L L L + +T + V R ++ L+ L Sbjct: 232 SNKLGNAGIAALCPGLLLPSCKLRTLWLWECDITAEGCKDLCRVLRAKQSLK---ELSLA 288 Query: 415 VNRDSD 420 N D Sbjct: 289 SNELKD 294 Score = 47.5 bits (111), Expect = 1e-05, Method: Composition-based stats. Identities = 71/341 (20%), Positives = 106/341 (31%), Gaps = 42/341 (12%) Query: 133 HLKALFFYRC-LGRAPQRIPAFLGRLGSSLQTLVLREN-----GFLGPIPDELGNLTNLK 186 ++ L C L A I + R S+L+ L L +N G L+ Sbjct: 82 KIQKLSLQNCGLTEAGCGILPGMLRSLSTLRELHLNDNPMGDAGLKLLCEGLQDPQCRLE 141 Query: 187 VLDLHKNHLNGS---IPLSFNRFSG-LRSLDLSGNRLTGSIPGFVLP-------ALSVLD 235 L L +L + S R + L LS N L + L L Sbjct: 142 KLQLEYCNLTATSCEPLASVLRVKADFKELVLSNNDLHEPGVRILCQGLKDSACQLESLK 201 Query: 236 LNQNLLTGPVPPTLT----SCGSLIKIDLSRNR-----VTGPIPESINRLNQLVLLDLSY 286 L +T L S SL ++DLS N+ + P + +L L L Sbjct: 202 LENCGITAANCKDLCDVVASKASLQELDLSSNKLGNAGIAALCPGLLLPSCKLRTLWLWE 261 Query: 287 NRLSG----PFPSSLQGLNSLQALMLKGNTKFST---TIPENAFKGLKNLMILVLSNTNI 339 ++ L+ SL+ L L N + E+ + L L + ++ Sbjct: 262 CDITAEGCKDLCRVLRAKQSLKELSLASNELKDEGARLLCESLLEPGCQLESLWIKTCSL 321 Query: 340 QGSI----PKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKH-----LSELRLNDNSLTGP 390 + LT+ SL L + N L E E L EL L D +T Sbjct: 322 TAASCPYFCSVLTKSRSLLELQMSSNPLGDEGVQELCKALSQPDTVLRELWLGDCDVTNS 381 Query: 391 VPFERDTVWRMRRKLRLYNNAGLCVNRDSDLDDAFGSKSGS 431 V R LR + + C+ L K S Sbjct: 382 GCSSLANVLLANRSLRELDLSNNCMGGPGVLQLLESLKQPS 422 Score = 37.8 bits (86), Expect = 0.011, Method: Composition-based stats. Identities = 33/133 (24%), Positives = 54/133 (40%), Gaps = 17/133 (12%) Query: 294 PSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKN----LMILVLSNTNIQ----GSIPK 345 S++Q +L L L+ N + +GL+N + L L N + G +P Sbjct: 45 SSAVQANPALTELSLRTNELGDGGVGL-VLQGLQNPTCKIQKLSLQNCGLTEAGCGILPG 103 Query: 346 SLTRLNSLRVLHLEGNNLTG-----EIPLEFRDVKHLSELRLNDNSLTGPVPFERDTVWR 400 L L++LR LHL N + L +L+L +LT +V R Sbjct: 104 MLRSLSTLRELHLNDNPMGDAGLKLLCEGLQDPQCRLEKLQLEYCNLTATSCEPLASVLR 163 Query: 401 MR---RKLRLYNN 410 ++ ++L L NN Sbjct: 164 VKADFKELVLSNN 176 >4PBW-B nrPDB Length = 283 Score = 50.6 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 26/124 (20%), Positives = 43/124 (34%), Gaps = 3/124 (2%) Query: 191 HKNHLNGSIPLSFNRFSGLRSLDL-SGNRLTGSIPGFVLPALSVLDLNQ-NLLTGPVPPT 248 K +N P N F L D S N T + ++ + + L Sbjct: 11 SKTDINCKKPDDGNLFPLLEGQDSGSSNGQTSIQITDISRNITSIHIENWKNLQTLNAVD 70 Query: 249 LTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALML 308 + L ++ + + + P + + L +DLS NRL+ Q L L L L Sbjct: 71 MELYTGLQRLTIRNSGLRNIQPRAFAKNPHLRYIDLSGNRLTTLSWQLFQTLR-LFDLRL 129 Query: 309 KGNT 312 + N Sbjct: 130 ERNP 133 Score = 44.4 bits (103), Expect = 1e-04, Method: Composition-based stats. Identities = 29/146 (19%), Positives = 55/146 (37%), Gaps = 17/146 (11%) Query: 274 NRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILV 333 N + + D+S N ++ +LQ L + L L Sbjct: 38 NGQTSIQITDISRN----ITSIHIENWKNLQTLNAVDMELY------------TGLQRLT 81 Query: 334 LSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLNDNSLTGPVPF 393 + N+ ++ P++ + LR + L GN LT F+ ++ L +LRL N Sbjct: 82 IRNSGLRNIQPRAFAKNPHLRYIDLSGNRLTTLSWQLFQTLR-LFDLRLERNPFQCSCDI 140 Query: 394 ERDTVWRMRRKLRLYNNAGLCVNRDS 419 +W+ + + L + C+N D+ Sbjct: 141 RWIQLWQEKGEANLQSQQLHCMNLDT 166 Score = 41.3 bits (95), Expect = 9e-04, Method: Composition-based stats. Identities = 21/71 (29%), Positives = 30/71 (42%), Gaps = 1/71 (1%) Query: 170 GFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPG-FVL 228 ++ T L+ L + + L P +F + LR +DLSGNRLT F Sbjct: 62 NLQTLNAVDMELYTGLQRLTIRNSGLRNIQPRAFAKNPHLRYIDLSGNRLTTLSWQLFQT 121 Query: 229 PALSVLDLNQN 239 L L L +N Sbjct: 122 LRLFDLRLERN 132 Score = 35.1 bits (79), Expect = 0.066, Method: Composition-based stats. Identities = 27/118 (22%), Positives = 39/118 (33%), Gaps = 8/118 (6%) Query: 148 QRIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFS 207 Q + A L + LQ L +R +G P +L+ +DL N L F Sbjct: 64 QTLNAVDMELYTGLQRLTIRNSGLRNIQPRAFAKNPHLRYIDLSGNRLTTLSWQLFQTL- 122 Query: 208 GLRSLDLSGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSL-IKIDLSRNR 264 L L L N P + + L Q + C +L + L RN Sbjct: 123 RLFDLRLERN------PFQCSCDIRWIQLWQEKGEANLQSQQLHCMNLDTAVILLRNM 174 >3JB9-j nrPDB Length = 239 Score = 49.8 bits (117), Expect = 3e-06, Method: Composition-based stats. Identities = 23/120 (19%), Positives = 33/120 (27%), Gaps = 5/120 (4%) Query: 200 PLSFNRFSGLRSLDLSGNRLTGSIPGFVLPALSV-LDLNQNLLTGPVPPTLTSCGSLIKI 258 P + LDL ++ VL + +D N + L + Sbjct: 12 PSFISPLKE-TELDLRWYQIPIIENLGVLRDVHDAIDFTDNDIRYL--GNFPRMKRLQTL 68 Query: 259 DLSRNRVTGPIPESINRLNQLVLLDLSYNRLSGPFPSS-LQGLNSLQALMLKGNTKFSTT 317 NR+T P+ L L L L+ N L L L L N Sbjct: 69 LCGNNRITAIAPDIGKVLPNLKTLSLAQNHLQEIADLDPLASCPQLTNLSCIDNPVAQKQ 128 Score = 40.5 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 20/60 (33%), Positives = 23/60 (38%), Gaps = 1/60 (1%) Query: 159 SSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLS-FNRFSGLRSLDLSGN 217 LQTL+ N PD L NLK L L +NHL L L +L N Sbjct: 63 KRLQTLLCGNNRITAIAPDIGKVLPNLKTLSLAQNHLQEIADLDPLASCPQLTNLSCIDN 122 Score = 37.8 bits (86), Expect = 0.010, Method: Composition-based stats. Identities = 20/102 (19%), Positives = 35/102 (34%), Gaps = 5/102 (4%) Query: 282 LDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQG 341 +D + N + + + LQ L+ N T I + K L NL L L+ ++Q Sbjct: 46 IDFTDNDIRYL--GNFPRMKRLQTLLCGNNR--ITAIAPDIGKVLPNLKTLSLAQNHLQE 101 Query: 342 SIP-KSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRL 382 L L L N + + + + L + Sbjct: 102 IADLDPLASCPQLTNLSCIDNPVAQKQYYRLYLIWRIPSLHI 143 Score = 37.1 bits (84), Expect = 0.020, Method: Composition-based stats. Identities = 20/80 (25%), Positives = 31/80 (38%), Gaps = 1/80 (1%) Query: 323 FKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLE-FRDVKHLSELR 381 F +K L L+ N I P L +L+ L L N+L L+ L+ L Sbjct: 59 FPRMKRLQTLLCGNNRITAIAPDIGKVLPNLKTLSLAQNHLQEIADLDPLASCPQLTNLS 118 Query: 382 LNDNSLTGPVPFERDTVWRM 401 DN + + +WR+ Sbjct: 119 CIDNPVAQKQYYRLYLIWRI 138 Score = 34.8 bits (78), Expect = 0.10, Method: Composition-based stats. Identities = 14/64 (21%), Positives = 21/64 (32%), Gaps = 3/64 (4%) Query: 179 LGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSI---PGFVLPALSVLD 235 + L+ L N + P L++L L+ N L P P L+ L Sbjct: 59 FPRMKRLQTLLCGNNRITAIAPDIGKVLPNLKTLSLAQNHLQEIADLDPLASCPQLTNLS 118 Query: 236 LNQN 239 N Sbjct: 119 CIDN 122 Score = 29.4 bits (64), Expect = 3.5, Method: Composition-based stats. Identities = 20/91 (21%), Positives = 29/91 (31%), Gaps = 4/91 (4%) Query: 128 LTRLKHLKALFFYRCLGRAPQRIPAFLGRLGSSLQTLVLRENGFLGPI-PDELGNLTNLK 186 L +K L C I +G++ +L+TL L +N D L + L Sbjct: 56 LGNFPRMKRLQTLLCGNNRITAIAPDIGKVLPNLKTLSLAQNHLQEIADLDPLASCPQLT 115 Query: 187 VLDLHKNHLNGSI---PLSFNRFSGLRSLDL 214 L N + R L LD Sbjct: 116 NLSCIDNPVAQKQYYRLYLIWRIPSLHILDF 146 Score = 29.0 bits (63), Expect = 4.7, Method: Composition-based stats. Identities = 14/79 (17%), Positives = 28/79 (35%), Gaps = 2/79 (2%) Query: 332 LVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLNDNSLTGPV 391 + ++ +I+ + R+ L+ L N +T P + + +L L L N L Sbjct: 46 IDFTDNDIRYL--GNFPRMKRLQTLLCGNNRITAIAPDIGKVLPNLKTLSLAQNHLQEIA 103 Query: 392 PFERDTVWRMRRKLRLYNN 410 + L +N Sbjct: 104 DLDPLASCPQLTNLSCIDN 122 >6ICZ-o nrPDB Length = 255 Score = 47.9 bits (112), Expect = 1e-05, Method: Composition-based stats. Identities = 15/89 (16%), Positives = 31/89 (34%), Gaps = 1/89 (1%) Query: 204 NRFSGLRSLDLSGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRN 263 ++D S N + +L L L +N N + + L ++ L+ N Sbjct: 39 ATLDQFDAIDFSDNEIRKLDGFPLLRRLKTLLVNNNRICRIGEGLDQALPCLTELILTNN 98 Query: 264 RVTGPIP-ESINRLNQLVLLDLSYNRLSG 291 + + + L L L + N ++ Sbjct: 99 SLVELGDLDPLASLKSLTYLSILRNPVTN 127 Score = 46.3 bits (108), Expect = 3e-05, Method: Composition-based stats. Identities = 27/136 (19%), Positives = 45/136 (33%), Gaps = 7/136 (5%) Query: 232 SVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSG 291 LDL + + ID S N + + L +L L ++ NR+ Sbjct: 22 RELDLRGYKIPVIENLG-ATLDQFDAIDFSDNEIRKL--DGFPLLRRLKTLLVNNNRICR 78 Query: 292 PFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSL---T 348 Q L L L+L N+ + LK+L L + + L Sbjct: 79 IGEGLDQALPCLTELILTNNSL-VELGDLDPLASLKSLTYLSILRNPVTNKKHYRLYVIY 137 Query: 349 RLNSLRVLHLEGNNLT 364 ++ +RVL + L Sbjct: 138 KVPQVRVLDFQKVKLK 153 Score = 38.2 bits (87), Expect = 0.008, Method: Composition-based stats. Identities = 23/114 (20%), Positives = 47/114 (41%), Gaps = 6/114 (5%) Query: 323 FKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLT---GEIPLEFRDVKHLSE 379 F L+ L L+++N I L L L L N+L PL +K L+ Sbjct: 60 FPLLRRLKTLLVNNNRICRIGEGLDQALPCLTELILTNNSLVELGDLDPL--ASLKSLTY 117 Query: 380 LRLNDNSLTGPVPFERDTVWRMRRKLRLYNNAGLCVNRDSDLDDAFGSKSGSTV 433 L + N +T + ++++ ++R+ + + + + + F K G+ + Sbjct: 118 LSILRNPVTNKKHYRLYVIYKV-PQVRVLDFQKVKLKERQEAEKMFKGKRGAQL 170 Score = 36.7 bits (83), Expect = 0.023, Method: Composition-based stats. Identities = 20/113 (17%), Positives = 35/113 (30%), Gaps = 7/113 (6%) Query: 330 MILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLNDNSLTG 389 L L I L+ + N + F ++ L L +N+N + Sbjct: 22 RELDLRGYKIPVIENLG-ATLDQFDAIDFSDNEIRKLD--GFPLLRRLKTLLVNNNRI-C 77 Query: 390 PVPFERDTVWRMRRKLRLYNNAGLCVNRDSDLDDAFGSKSGSTVRLCDAETSR 442 + D +L L NN + DLD KS + + + + Sbjct: 78 RIGEGLDQALPCLTELILTNN---SLVELGDLDPLASLKSLTYLSILRNPVTN 127 >4PBV-A nrPDB Length = 268 Score = 45.9 bits (107), Expect = 4e-05, Method: Composition-based stats. Identities = 18/99 (18%), Positives = 34/99 (34%), Gaps = 2/99 (2%) Query: 215 SGNRLTGSIPGFVLPALSVLDLNQ-NLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESI 273 L + G ++ + + L + L ++ + + + P + Sbjct: 21 DDGNLFPLLEGQDSRNITSIHIENWKNLQTLNAVDMELYTGLQRLTIRNSGLRNIQPRAF 80 Query: 274 NRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNT 312 + L +DLS NRL+ Q L L L L+ N Sbjct: 81 AKNPHLRYIDLSGNRLTTLSWQLFQTLR-LFDLRLERNP 118 Score = 41.7 bits (96), Expect = 8e-04, Method: Composition-based stats. Identities = 21/71 (29%), Positives = 30/71 (42%), Gaps = 1/71 (1%) Query: 170 GFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPG-FVL 228 ++ T L+ L + + L P +F + LR +DLSGNRLT F Sbjct: 47 NLQTLNAVDMELYTGLQRLTIRNSGLRNIQPRAFAKNPHLRYIDLSGNRLTTLSWQLFQT 106 Query: 229 PALSVLDLNQN 239 L L L +N Sbjct: 107 LRLFDLRLERN 117 Score = 40.9 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 25/119 (21%), Positives = 52/119 (43%), Gaps = 2/119 (1%) Query: 301 NSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEG 360 ++ ++ ++ N K T+ + L L + N+ ++ P++ + LR + L G Sbjct: 35 RNITSIHIE-NWKNLQTLNAVDMELYTGLQRLTIRNSGLRNIQPRAFAKNPHLRYIDLSG 93 Query: 361 NNLTGEIPLEFRDVKHLSELRLNDNSLTGPVPFERDTVWRMRRKLRLYNNAGLCVNRDS 419 N LT F+ ++ L +LRL N +W+ + + L + C+N D+ Sbjct: 94 NRLTTLSWQLFQTLR-LFDLRLERNPFQCSCDIRWIQLWQEKGEANLQSQQLHCMNLDT 151 Score = 36.7 bits (83), Expect = 0.026, Method: Composition-based stats. Identities = 19/95 (20%), Positives = 32/95 (33%), Gaps = 12/95 (12%) Query: 194 HLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCG 253 ++ ++ L ++D+ + L L + + L P Sbjct: 36 NITSIHIENWKNLQTLNAVDM-----------ELYTGLQRLTIRNSGLRNIQPRAFAKNP 84 Query: 254 SLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNR 288 L IDLS NR+T + L +L L L N Sbjct: 85 HLRYIDLSGNRLTTLSWQLFQTL-RLFDLRLERNP 118 Score = 35.5 bits (80), Expect = 0.060, Method: Composition-based stats. Identities = 27/118 (22%), Positives = 39/118 (33%), Gaps = 8/118 (6%) Query: 148 QRIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFS 207 Q + A L + LQ L +R +G P +L+ +DL N L F Sbjct: 49 QTLNAVDMELYTGLQRLTIRNSGLRNIQPRAFAKNPHLRYIDLSGNRLTTLSWQLFQTL- 107 Query: 208 GLRSLDLSGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSL-IKIDLSRNR 264 L L L N P + + L Q + C +L + L RN Sbjct: 108 RLFDLRLERN------PFQCSCDIRWIQLWQEKGEANLQSQQLHCMNLDTAVILLRNM 159 >2IFG-A nrPDB Length = 347 Score = 45.5 bits (106), Expect = 5e-05, Method: Composition-based stats. Identities = 27/123 (21%), Positives = 41/123 (33%), Gaps = 26/123 (21%) Query: 249 LTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALML 308 L +L ++ I L L+L L+GL L+ L Sbjct: 27 LPGAENLTELY-------------IENQQHLQHLEL----------RDLRGLGELR--NL 61 Query: 309 KGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIP 368 + +AF L L LS ++ K++ L SL+ L L GN L Sbjct: 62 TIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGL-SLQELVLSGNPLHCSCA 120 Query: 369 LEF 371 L + Sbjct: 121 LRW 123 Score = 45.5 bits (106), Expect = 6e-05, Method: Composition-based stats. Identities = 23/88 (26%), Positives = 39/88 (44%), Gaps = 2/88 (2%) Query: 229 PALSVLDLNQN-LLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYN 287 L+ L + L L G L + + ++ + P++ + +L L+LS+N Sbjct: 31 ENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFN 90 Query: 288 RLSGPFPSSLQGLNSLQALMLKGNTKFS 315 L ++QGL SLQ L+L GN Sbjct: 91 ALESLSWKTVQGL-SLQELVLSGNPLHC 117 Score = 41.3 bits (95), Expect = 9e-04, Method: Composition-based stats. Identities = 29/154 (18%), Positives = 46/154 (29%), Gaps = 25/154 (16%) Query: 176 PDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPGFVLPALSVLD 235 L NL L + L DL G L L L Sbjct: 24 LHHLPGAENLTELYIENQQ----------HLQHLELRDLRG-----------LGELRNLT 62 Query: 236 LNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSGPFPS 295 + ++ L P L +++LS N + +++ L L L LS N L Sbjct: 63 IVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGL-SLQELVLSGNPLHC--SC 119 Query: 296 SLQGLNSLQALMLKGNTKFSTTI-PENAFKGLKN 328 +L+ L + L G + + + N Sbjct: 120 ALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPN 153 Score = 39.8 bits (91), Expect = 0.003, Method: Composition-based stats. Identities = 24/94 (25%), Positives = 36/94 (38%), Gaps = 3/94 (3%) Query: 323 FKGLKNLMILVLSNT-NIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELR 381 G +NL L + N ++Q + L L LR L + + L P F LS L Sbjct: 27 LPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLN 86 Query: 382 LNDNSLTGPVPFERDTVWRMRRKLRLYNNAGLCV 415 L+ N+L + ++L L N C Sbjct: 87 LSFNALESL--SWKTVQGLSLQELVLSGNPLHCS 118 Score = 39.8 bits (91), Expect = 0.003, Method: Composition-based stats. Identities = 21/92 (22%), Positives = 36/92 (39%), Gaps = 2/92 (2%) Query: 297 LQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVL 356 L G +L L ++ N + + +GL L L + + ++ P + L L Sbjct: 27 LPGAENLTELYIE-NQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRL 85 Query: 357 HLEGNNLTGEIPLEFRDVKHLSELRLNDNSLT 388 +L N L + + L EL L+ N L Sbjct: 86 NLSFNALESLSWKTVQGL-SLQELVLSGNPLH 116 Score = 34.0 bits (76), Expect = 0.16, Method: Composition-based stats. Identities = 27/112 (24%), Positives = 38/112 (33%), Gaps = 11/112 (9%) Query: 142 CLGRAPQRIPAFLGRLGSSLQTLVLRENGFLGPIPD----------ELGNLTNLKVLDLH 191 C + SL L EN I + +L L L+ L + Sbjct: 5 CCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIV 64 Query: 192 KNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPGFVLP-ALSVLDLNQNLLT 242 K+ L P +F+ L L+LS N L V +L L L+ N L Sbjct: 65 KSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLH 116 >4WYK-A nrPDB Length = 461 Score = 45.2 bits (105), Expect = 6e-05, Method: Composition-based stats. Identities = 16/68 (23%), Positives = 27/68 (39%) Query: 298 QGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLH 357 + + L +L L N + + + NL IL LS ++ + L L Sbjct: 168 ENIPELLSLNLSNNRLYRLDDMSSIVQKAPNLKILNLSGNELKSERELDKIKGLKLEELW 227 Query: 358 LEGNNLTG 365 L+GN+L Sbjct: 228 LDGNSLCD 235 Score = 41.3 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 37/190 (19%), Positives = 67/190 (35%), Gaps = 35/190 (18%) Query: 232 SVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINRLN---------QLVLL 282 +LD ++ + + L ++ PE + +L L Sbjct: 84 KILDRENRRISIIINSSAPPHTILNEL----------KPEQVEQLKLIMSKRYDGSQQAL 133 Query: 283 DLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGS 342 DL L Q ++ + L + + I E + L+ L LSN + Sbjct: 134 DLKG--LRSDPDLVAQNIDVV--LNRRSCMAATLRIIEE---NIPELLSLNLSNNRLYRL 186 Query: 343 IPKS--LTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLNDNSL-------TGPVPF 393 S + + +L++L+L GN L E L+ L EL L+ NSL + + Sbjct: 187 DDMSSIVQKAPNLKILNLSGNELKSERELDKIKGLKLEELWLDGNSLCDTFRDQSTYISA 246 Query: 394 ERDTVWRMRR 403 R+ ++ R Sbjct: 247 IRERFPKLLR 256 Score = 39.0 bits (89), Expect = 0.004, Method: Composition-based stats. Identities = 25/106 (23%), Positives = 36/106 (33%), Gaps = 15/106 (14%) Query: 204 NRFSGLRSLDLSGNRLTG----SIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKID 259 L SL+LS NRL S P L +L+L+ N L L ++ Sbjct: 168 ENIPELLSLNLSNNRLYRLDDMSSIVQKAPNLKILNLSGNELKSERELDKIKGLKLEELW 227 Query: 260 LSRNRV-------TGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQ 298 L N + + I R +L+ LD P P + Sbjct: 228 LDGNSLCDTFRDQSTYISAIRERFPKLLRLDGH----ELPPPIAFD 269 Score = 28.6 bits (62), Expect = 6.4, Method: Composition-based stats. Identities = 30/131 (22%), Positives = 44/131 (33%), Gaps = 17/131 (12%) Query: 136 ALFFYRCLGRAPQRIPAFLGRLGSSLQTLVLRENGFLGP--IPDELGNLTNLKVLDLHKN 193 L C+ + I + L S L L N + + NLK+L+L N Sbjct: 152 VLNRRSCMAATLRIIEENIPELLS----LNLSNNRLYRLDDMSSIVQKAPNLKILNLSGN 207 Query: 194 HLNGSIPLSFNRFSGLRSLDLSGNRLTG---------SIPGFVLPALSVLDLNQNLLTGP 244 L L + L L L GN L S P L L L+ + L P Sbjct: 208 ELKSERELDKIKGLKLEELWLDGNSLCDTFRDQSTYISAIRERFPKL--LRLDGHELPPP 265 Query: 245 VPPTLTSCGSL 255 + + + +L Sbjct: 266 IAFDVEAPTTL 276 >1KOH-A nrPDB Length = 277 Score = 43.6 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 16/68 (23%), Positives = 28/68 (41%) Query: 298 QGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLH 357 + + L +L L N + + + NL IL LS ++ + L L Sbjct: 167 ENIPELLSLNLSNNRLYRLDDMSSIVQKAPNLKILNLSGNELKSERELDKIKGLKLEELW 226 Query: 358 LEGNNLTG 365 L+GN+L+ Sbjct: 227 LDGNSLSD 234 Score = 40.5 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 36/166 (21%), Positives = 63/166 (37%), Gaps = 22/166 (13%) Query: 232 SVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSG 291 +LD ++ + + L ++ PE + +L L +S Sbjct: 83 KILDRENRRISIIINSSAPPHTILNEL----------KPEQVEQLK----LIMSKRYDGS 128 Query: 292 PFPSSLQGLNS-----LQALMLKGNTKFSTTIPENAFK-GLKNLMILVLSNTNIQGSIPK 345 L+GL S Q + + N + S + + L+ L LSN + Sbjct: 129 QQALDLKGLRSDPDLVAQNIDVVLNRRSSMAATLRIIEENIPELLSLNLSNNRLYRLDDM 188 Query: 346 S--LTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLNDNSLTG 389 S + + +L++L+L GN L E L+ L EL L+ NSL+ Sbjct: 189 SSIVQKAPNLKILNLSGNELKSERELDKIKGLKLEELWLDGNSLSD 234 Score = 39.0 bits (89), Expect = 0.004, Method: Composition-based stats. Identities = 21/79 (26%), Positives = 31/79 (39%), Gaps = 4/79 (5%) Query: 220 TGSIPGFVLPALSVLDLNQNLLTGPVP--PTLTSCGSLIKIDLSRNRVTGPIP-ESINRL 276 T I +P L L+L+ N L + +L ++LS N + + I L Sbjct: 161 TLRIIEENIPELLSLNLSNNRLYRLDDMSSIVQKAPNLKILNLSGNELKSERELDKIKGL 220 Query: 277 NQLVLLDLSYNRLSGPFPS 295 +L L L N LS F Sbjct: 221 -KLEELWLDGNSLSDTFRD 238 Score = 38.6 bits (88), Expect = 0.007, Method: Composition-based stats. Identities = 24/84 (28%), Positives = 39/84 (46%), Gaps = 4/84 (4%) Query: 274 NRLNQLVLLDLSYNRLSGP--FPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMI 331 + +L+ L+LS NRL S +Q +L+ L L GN S + KGLK L Sbjct: 167 ENIPELLSLNLSNNRLYRLDDMSSIVQKAPNLKILNLSGNELKSER-ELDKIKGLK-LEE 224 Query: 332 LVLSNTNIQGSIPKSLTRLNSLRV 355 L L ++ + T ++++R Sbjct: 225 LWLDGNSLSDTFRDQSTYISAIRE 248 Score = 29.4 bits (64), Expect = 3.5, Method: Composition-based stats. Identities = 26/106 (24%), Positives = 39/106 (36%), Gaps = 13/106 (12%) Query: 161 LQTLVLRENGFLGP--IPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNR 218 L +L L N + + NLK+L+L N L L + L L L GN Sbjct: 172 LLSLNLSNNRLYRLDDMSSIVQKAPNLKILNLSGNELKSERELDKIKGLKLEELWLDGNS 231 Query: 219 LTG---------SIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSL 255 L+ S P L L L+ + L P+ + + +L Sbjct: 232 LSDTFRDQSTYISAIRERFPKL--LRLDGHELPPPIAFDVEAPTTL 275 >4K17-A nrPDB Length = 669 Score = 43.2 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 68/361 (18%), Positives = 119/361 (32%), Gaps = 57/361 (15%) Query: 128 LTRLKHLKALFFYRCLGRA--PQRIPAFLGRLGSS-LQTLVLRENGF----LGPIPDELG 180 ++R L+ L R Q++ L +S L T+ L N + + + Sbjct: 243 VSRSNRLEELVLENAGLRIDFAQKLAGALAHNPNSGLHTINLAGNSLEDRGVSSLSIQFA 302 Query: 181 NLTN-LKVLDLHK--------NHLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPG------ 225 L LK L+L K N L S+ + S L LDLSGN L G Sbjct: 303 KLPKGLKHLNLSKTSLSPKGVNSLCQSLSANPLTASTLTHLDLSGNALRGDDLSHMYNFL 362 Query: 226 FVLPALSVLDLNQNL--LTGPVPPTLTSCGS-LIKIDLSRNRVT----GPIPESINRLNQ 278 + LDL+ L L C L ++LSR+ + +P S + Sbjct: 363 AQPNTIVHLDLSNTECSLEMVCSALLRGCLQCLAVLNLSRSVFSHRKGKEVPPSFKQFFS 422 Query: 279 ----LVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVL 334 L+ ++LS +LS +L L L N L N + Sbjct: 423 SSLALIQINLSGTKLSPEPLKAL-------LLGLACNHSLKGVS-----LDLSNCELGHC 470 Query: 335 SNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLNDNSLTGPVPFE 394 + + + ++++ L + N L ++ + L+ N + Sbjct: 471 LRSGGAQVLEGCIAEIHNITSLDISDNGLESDL--------STLIVWLSKNRSIQHLALG 522 Query: 395 RD-TVWRMRRKLRLYNNAGLCVNRDSDLDDAFGSKSGSTVRLCDAETSRPAPSGTVQHLS 453 ++ + + + +N V D D S S + +L T G+ L+ Sbjct: 523 KNFNNMKSKNLTPVLDNL---VQMIQDEDSPLQSLSLADSKLKAEVTIIINALGSNTSLT 579 Query: 454 R 454 + Sbjct: 580 K 580 >2CA6-A nrPDB Length = 386 Score = 43.2 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 44/230 (19%), Positives = 70/230 (30%), Gaps = 35/230 (15%) Query: 251 SCGSLIKIDLSRNRVT-GPIPESINRLNQ---LVLLDLSYNRLSGPFPSSLQGLNSLQAL 306 C L + LS N I+ L++ L L L N L + + +LQ L Sbjct: 92 KCPKLHTVRLSDNAFGPTAQEPLIDFLSKHTPLEHLYLHNNGLGPQAGAKIA--RALQEL 149 Query: 307 MLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSI----PKSLTRLNSLRVLHLEGNN 362 + K L ++ ++ K+ L + + N Sbjct: 150 AVNKKA-----------KNAPPLRSIICGRNRLENGSMKEWAKTFQSHRLLHTVKMVQNG 198 Query: 363 L--TGEIPLEFRDVKH---LSELRLNDNSLTGPVPFERDTVWRMRRKLRL--YNNAGLCV 415 + G L + + L L L DN+ T + LR N+ L Sbjct: 199 IRPEGIEHLLLEGLAYCQELKVLDLQDNTFTHLGSSALAIALKSWPNLRELGLNDCLLSA 258 Query: 416 NRDSDLDDAFGSKS---GSTVRLCDAETSRPAPSGTVQHLSREEDGALPD 462 + + DAF T+RL E V+ L D +PD Sbjct: 259 RGAAAVVDAFSKLENIGLQTLRLQYNEIE----LDAVRTLKTVIDEKMPD 304 Score = 29.8 bits (65), Expect = 2.9, Method: Composition-based stats. Identities = 21/101 (20%), Positives = 32/101 (31%), Gaps = 5/101 (4%) Query: 102 SLSFGALSDDTAFPTCDPQRSYVSESLTRLKHLKALFFYRCLGRAPQRIPAFLGRLGSSL 161 L L D+T + +S L+ L A + AF L Sbjct: 217 ELKVLDLQDNTFTHLGSSALAIALKSWPNLRELGLNDCLLSARGAAAVVDAFSKLENIGL 276 Query: 162 QTLVLRENGFLGPIPDELG-----NLTNLKVLDLHKNHLNG 197 QTL L+ N L + +L L+L+ N + Sbjct: 277 QTLRLQYNEIELDAVRTLKTVIDEKMPDLLFLELNGNRFSE 317 >4NUY-A nrPDB Length = 899 Score = 42.1 bits (97), Expect = 6e-04, Method: Composition-based stats. Identities = 25/103 (24%), Positives = 38/103 (36%), Gaps = 4/103 (3%) Query: 263 NRVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENA 322 N+ + L+++ LD S L L ++ K N + TIP + Sbjct: 402 NKFKKLAQLDLIGLSRITKLDRS--VLPANMKPGKDTLETVLETYKKDNKEEPATIPPVS 459 Query: 323 FK--GLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNL 363 K GL L L LS + + L SL + + GN L Sbjct: 460 LKVSGLTGLKELDLSGFDRETLAGLDAATLTSLEKVDISGNKL 502 Score = 37.1 bits (84), Expect = 0.020, Method: Composition-based stats. Identities = 35/199 (17%), Positives = 57/199 (28%), Gaps = 20/199 (10%) Query: 167 RENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLD---LSGNRLTGS- 222 R NG L + +L L N L S + LD L N G Sbjct: 383 RFNGTLRLDNPAIQSLEGL-------NKFKKLAQLDLIGLSRITKLDRSVLPANMKPGKD 435 Query: 223 IPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLL 282 VL + + PV ++ L ++DLS L L + Sbjct: 436 TLETVLETYKKDNKEEPATIPPVSLKVSGLTGLKELDLSGFDRETLAGLDAATLTSLEKV 495 Query: 283 DLSYNRLSGPFPSS----LQGLNSLQALMLKGNTK---FSTTIPENAFKGLKNLMILVL- 334 D+S N+L + + S + + N + F P + L L Sbjct: 496 DISGNKLDLAPGTENRQIFDTMLSTISNHVGSNEQTVKFDKQKPTGHYPDTYGKTSLRLP 555 Query: 335 -SNTNIQGSIPKSLTRLNS 352 +N + + + Sbjct: 556 VANEKVDLQSQLLFGTVTN 574 Score = 35.1 bits (79), Expect = 0.068, Method: Composition-based stats. Identities = 26/126 (20%), Positives = 39/126 (30%), Gaps = 16/126 (12%) Query: 104 SFGALSDDTAFPTCDPQRSYVSESLTRLKHLKALFFYRCLGRAPQRIPAFLGRLGSSLQT 163 S L+ D L+R+ L P + L + L+T Sbjct: 397 SLEGLNKFKKLAQLDLI------GLSRITKLDRSVL-------PANMKPGKDTLETVLET 443 Query: 164 LVLRENGFLGPIPD---ELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLT 220 IP ++ LT LK LDL L + L +D+SGN+L Sbjct: 444 YKKDNKEEPATIPPVSLKVSGLTGLKELDLSGFDRETLAGLDAATLTSLEKVDISGNKLD 503 Query: 221 GSIPGF 226 + Sbjct: 504 LAPGTE 509 Score = 30.1 bits (66), Expect = 2.4, Method: Composition-based stats. Identities = 24/142 (16%), Positives = 46/142 (32%), Gaps = 14/142 (9%) Query: 88 IECMPDQDNVYHVVSLSFGALSDDTAFPTCDPQRSYVSESLTRLK---HLKALFFYRCLG 144 I+ + + + L LS T RS + ++ K + + Sbjct: 395 IQSLEGLNKFKKLAQLDLIGLSRIT-----KLDRSVLPANMKPGKDTLETVLETYKKDNK 449 Query: 145 RAPQRIPAFLGRL--GSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPL- 201 P IP ++ + L+ L L + LT+L+ +D+ N L+ + Sbjct: 450 EEPATIPPVSLKVSGLTGLKELDLSGFDRETLAGLDAATLTSLEKVDISGNKLDLAPGTE 509 Query: 202 ---SFNRFSGLRSLDLSGNRLT 220 F+ S + N T Sbjct: 510 NRQIFDTMLSTISNHVGSNEQT 531 >5LJ5-W nrPDB Length = 238 Score = 39.8 bits (91), Expect = 0.003, Method: Composition-based stats. Identities = 23/125 (18%), Positives = 42/125 (33%), Gaps = 8/125 (6%) Query: 165 VLRENGFLGPIPDELGNLTN-LKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSI 223 L+ +P L +LT +LDL N L +R + +L L N + Sbjct: 33 DLQLETDSESMPSSLKHLTKPTHILDLTNNDLIMIPD--LSRRDDIHTLLLGRNNIVEVD 90 Query: 224 PGFVLPALSVLDLNQNLLTGPVPPT--LTSCGSLIKIDLSRNR---VTGPIPESINRLNQ 278 + + L L+ N + + +L + L N+ + + + Sbjct: 91 GRLLPMNVQNLTLSNNSIRRFEDLQRLRRAPRTLKNLTLIGNQVCHLANYREHVLRLVPH 150 Query: 279 LVLLD 283 L LD Sbjct: 151 LETLD 155 Score = 35.9 bits (81), Expect = 0.042, Method: Composition-based stats. Identities = 22/130 (16%), Positives = 43/130 (33%), Gaps = 8/130 (6%) Query: 235 DLNQNLLTGPVPPTLTSCGS-LIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSGPF 293 DL + +P +L +DL+ N + ++R + + L L N + Sbjct: 33 DLQLETDSESMPSSLKHLTKPTHILDLTNNDLIMIPD--LSRRDDIHTLLLGRNNIVEVD 90 Query: 294 PSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNT---NIQGSIPKSLTRL 350 L ++Q L L N+ + + + L L L ++ L + Sbjct: 91 GRLLPM--NVQNLTLSNNSIRRFEDLQRLRRAPRTLKNLTLIGNQVCHLANYREHVLRLV 148 Query: 351 NSLRVLHLEG 360 L L + Sbjct: 149 PHLETLDFQN 158 Score = 29.4 bits (64), Expect = 3.8, Method: Composition-based stats. Identities = 21/118 (17%), Positives = 32/118 (27%), Gaps = 10/118 (8%) Query: 104 SFGALSDDTAFPTCDPQRSYVSESLTRLKHLKALFFYRCLGRAPQRIPAFLGRLGSSLQT 163 S L+ T + L+R + L R + L ++Q Sbjct: 46 SLKHLTKPTHILDLTNNDLIMIPDLSRRDDIHTLLLGRN-----NIVEVDGRLLPMNVQN 100 Query: 164 LVLRENGF-----LGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSG 216 L L N L + L NL ++ HL L +LD Sbjct: 101 LTLSNNSIRRFEDLQRLRRAPRTLKNLTLIGNQVCHLANYREHVLRLVPHLETLDFQN 158 >6FE8-D nrPDB Length = 519 Score = 38.6 bits (88), Expect = 0.006, Method: Composition-based stats. Identities = 44/271 (16%), Positives = 86/271 (31%), Gaps = 61/271 (22%) Query: 191 HKNHLNGSI----PLSFNRFSGLRSLDLSGNRLTGSIPGF--------------VLPALS 232 N L S LR + + G +L + F V ++ Sbjct: 252 THNQLTSISVIRTIRSMESMKSLRKITVRGEKLYELLINFHGFRDNPGKTISYIVKRRIN 311 Query: 233 VLDLNQ-NLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSG 291 + L++ N ++ T +L K+ LSR + +DL+ S Sbjct: 312 EIRLSRMNQISRTGLADFTRWDNLQKLVLSR----------------VAYIDLN----SI 351 Query: 292 PFPSSLQGLN-----SLQALMLKGNTKFSTTIPENAFKGL-------KNLMILVLSNTNI 339 FP + + L ++ ++ N + + FK L K L +T I Sbjct: 352 VFPKNFKSLTMKRVSKIKWWNIEENILKELKVDKRTFKSLYIKEDDSKFTKFFNLRHTRI 411 Query: 340 QGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLND--NSLTGPVPFERDT 397 + + ++ LR + L FR + H+ +++ N++ P Sbjct: 412 KELDKSEINQITYLRC--------QAIVWLSFRTLNHIKLQNVSEVFNNIIVPRALFDSK 463 Query: 398 VWRMRRKLRLYNNAGLCVNRDSDLDDAFGSK 428 + R ++ + S+ GSK Sbjct: 464 RVEIYRCEKISQVLVIGSRSGSENLYFQGSK 494 >6MDV-A nrPDB Length = 802 Score = 37.1 bits (84), Expect = 0.018, Method: Composition-based stats. Identities = 19/111 (17%), Positives = 36/111 (32%), Gaps = 13/111 (11%) Query: 186 KVLDLHKNHLNGSIPLSFNRFSGLRSLDLSG-NRLTGSIPGFVLPALSVLDLNQNLLTGP 244 K L L + + + S L+ L+L + + P + ++ Sbjct: 381 KTLVLTGDKIQNLKG--LEKLSKLQKLELRQLSNVKEITPELLPESMKKDA--------- 429 Query: 245 VPPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSGPFPS 295 + L K++LS +N + L D+S+N L S Sbjct: 430 -ELVMVGMTGLEKLNLSGLNRQTLDGIDVNSITHLTSFDISHNSLDLSEKS 479 Score = 35.9 bits (81), Expect = 0.043, Method: Composition-based stats. Identities = 17/107 (15%), Positives = 40/107 (37%), Gaps = 15/107 (14%) Query: 257 KIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFST 316 + L+ +++ + +L++L L+L + L++++ + + + Sbjct: 382 TLVLTGDKIQNLK--GLEKLSKLQKLEL-------------RQLSNVKEITPELLPESMK 426 Query: 317 TIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNL 363 E G+ L L LS N Q + + L + N+L Sbjct: 427 KDAELVMVGMTGLEKLNLSGLNRQTLDGIDVNSITHLTSFDISHNSL 473 Score = 35.1 bits (79), Expect = 0.070, Method: Composition-based stats. Identities = 23/107 (21%), Positives = 42/107 (39%), Gaps = 15/107 (14%) Query: 281 LLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQ 340 L L+ +++ L+ L+ LQ L L+ + PE + +K LV+ Sbjct: 382 TLVLTGDKIQNLKG--LEKLSKLQKLELRQLSNVKEITPELLPESMKKDAELVM------ 433 Query: 341 GSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLNDNSL 387 + L L+L G N ++ + HL+ ++ NSL Sbjct: 434 -------VGMTGLEKLNLSGLNRQTLDGIDVNSITHLTSFDISHNSL 473 Score = 34.4 bits (77), Expect = 0.12, Method: Composition-based stats. Identities = 20/109 (18%), Positives = 34/109 (31%), Gaps = 17/109 (15%) Query: 126 ESLTRLKHLKALFFYRCLGRAPQRIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNL 185 E L++L+ L+ P+ +P + +T L Sbjct: 397 EKLSKLQKLELRQLSNVKEITPELLPE-----------------SMKKDAELVMVGMTGL 439 Query: 186 KVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPGFVLPALSVL 234 + L+L + + N + L S D+S N L S L L Sbjct: 440 EKLNLSGLNRQTLDGIDVNSITHLTSFDISHNSLDLSEKSEDRKLLMTL 488 >2P1O-B nrPDB Length = 594 Score = 34.0 bits (76), Expect = 0.14, Method: Composition-based stats. Identities = 32/208 (15%), Positives = 60/208 (28%), Gaps = 30/208 (14%) Query: 102 SLSFGALSDDTAFPTCDPQRSYVSESLTRLKHLKALFFYRCLGRAPQRIPAFLGRLGSSL 161 +L L + S+ ++ T L L + S+L Sbjct: 157 NLKELDLRESDVDDVSGHWLSHFPDTYTSLVSLNISCLASEVS-------------FSAL 203 Query: 162 QTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTG 221 + LV R + L L L L ++ D+ + L+ Sbjct: 204 ERLVTRCPNLKSLKLNRAVPLEKLATLLQRAPQLEELGTG---GYTAEVRPDV-YSGLSV 259 Query: 222 SIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINRL----N 277 ++ G L L + + +P + C L ++LS + +L Sbjct: 260 ALSGC--KELRCLSGFWDAVPAYLPAVYSVCSRLTTLNLS---YATVQSYDLVKLLCQCP 314 Query: 278 QLVLLDLSYNRLSGPFPSSLQGLNSLQA 305 +L L + L + L+ L S Sbjct: 315 KLQRLWV----LDYIEDAGLEVLASTCK 338 Score = 33.2 bits (74), Expect = 0.25, Method: Composition-based stats. Identities = 21/121 (17%), Positives = 39/121 (32%), Gaps = 6/121 (4%) Query: 278 QLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNT 337 +L + ++ + L S + + L+L FST +NL L L + Sbjct: 111 RLKRMVVTDDCLELIAKSF----KNFKVLVLSSCEGFSTDGLAAIAATCRNLKELDLRES 166 Query: 338 NIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSEL--RLNDNSLTGPVPFER 395 ++ L+ + N + F ++ L L L VP E+ Sbjct: 167 DVDDVSGHWLSHFPDTYTSLVSLNISCLASEVSFSALERLVTRCPNLKSLKLNRAVPLEK 226 Query: 396 D 396 Sbjct: 227 L 227 >1K0G-A nrPDB Length = 453 Score = 33.6 bits (75), Expect = 0.22, Method: Composition-based stats. Identities = 17/102 (16%), Positives = 32/102 (31%), Gaps = 8/102 (7%) Query: 190 LHKNHLNGSIPLSFNRFSGLRSLDLS--------GNRLTGSIPGFVLPALSVLDLNQNLL 241 L N N + +F R L LS + + LP L + Sbjct: 231 LQLNQANRAPFSAFLRLEQGAILSLSPERFILCDNSEIQTRPIKGTLPRLPDPQEDSKQA 290 Query: 242 TGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLLD 283 +L+ +DL RN + ++ +L +++ Sbjct: 291 VKLANSAKDRAENLMIVDLMRNDIGRVAVAGSVKVPELFVVE 332 >2B3T-A nrPDB Length = 276 Score = 31.7 bits (70), Expect = 0.82, Method: Composition-based stats. Identities = 18/92 (19%), Positives = 27/92 (29%), Gaps = 6/92 (6%) Query: 275 RLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENA------FKGLKN 328 L Q L+ + L Q M+ N + + F+ L Sbjct: 147 SLAQRNAQHLAIKNIHILQSDWFSALAGQQFAMIVSNPPYIDEQDPHLQQGDVRFEPLTA 206 Query: 329 LMILVLSNTNIQGSIPKSLTRLNSLRVLHLEG 360 L+ +I I +S L S L LE Sbjct: 207 LVAADSGMADIVHIIEQSRNALVSGGFLLLEH 238 >2JAN-A nrPDB Length = 432 Score = 30.9 bits (68), Expect = 1.2, Method: Composition-based stats. Identities = 15/75 (20%), Positives = 29/75 (38%), Gaps = 1/75 (1%) Query: 15 SIVSPLVRSFTVITSDSTAPSALIDG-PQTGFTMTNDGARTEPDEQDAVYDIMRATGNDW 73 + ++ +R TV +P ++D +G + + AR E + +R +W Sbjct: 336 ATLAAALRETTVAELKPGSPDGIVDLLVASGLSASKGAARRTIHEGGVSVNNIRVDNEEW 395 Query: 74 AAAIPDVCRGRWHGI 88 D GRW + Sbjct: 396 VPQSSDFLHGRWLVL 410 >1EDZ-A nrPDB Length = 320 Score = 29.8 bits (65), Expect = 3.0, Method: Composition-based stats. Identities = 10/44 (22%), Positives = 19/44 (43%), Gaps = 1/44 (2%) Query: 374 VKHLSELRLNDNSLTGPVPFERDTVWRMRRKLRLYNNAGLCVNR 417 ++ L +N L +P + ++ L++YNN NR Sbjct: 132 YHNVRYLD-KENRLKSILPCTPLAIVKILEFLKIYNNLLPEGNR 174 >5XC2-A nrPDB Length = 796 Score = 29.8 bits (65), Expect = 3.0, Method: Composition-based stats. Identities = 12/98 (12%), Positives = 31/98 (31%), Gaps = 2/98 (2%) Query: 69 TGNDWAAAIPDVCRGRWHGIECMPDQDNVYHVVSLSFGALSDDTAFPTCDPQRSYVSESL 128 GN+W ++ W ++ P+ + +++ ++ + T + + L Sbjct: 358 VGNEWTLRETELSPVEWLPLQAAPNPTTINEIMTEINKDIASNYTQETAKEDNYFSGKGL 417 Query: 129 TRLKHLKALFFYRCLGRAPQRIPAFLGRLGSSLQTLVL 166 + L + + R P L+ L Sbjct: 418 QKFAMLALILNKSDQTQL--RNPELAQIALDKLKAAFL 453 >6QE6-A nrPDB Length = 245 Score = 29.8 bits (65), Expect = 3.1, Method: Composition-based stats. Identities = 22/146 (15%), Positives = 46/146 (31%), Gaps = 8/146 (5%) Query: 276 LNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLS 335 L + L+ ++ + L+ + + + L + T L IL Sbjct: 76 LKNVEKFGLTG-QIFTILSNGLEFVKNKEILNIDYVTICG-------LGSQTILEILKND 127 Query: 336 NTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLNDNSLTGPVPFER 395 + I I S T + +LR+ + N L + D + + +N N + + Sbjct: 128 HQKISNYIICSNTSVKNLRLWAVSHNYLIKYESFIYEDDHYYWLIEINKNKYSDHLEELE 187 Query: 396 DTVWRMRRKLRLYNNAGLCVNRDSDL 421 + + N S+L Sbjct: 188 IEFGSKQFFNKNSLYISYLENEISNL 213 >2A90-A nrPDB Length = 240 Score = 29.4 bits (64), Expect = 3.6, Method: Composition-based stats. Identities = 19/110 (17%), Positives = 37/110 (33%), Gaps = 23/110 (20%) Query: 330 MILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLNDNSLTG 389 L LSNT+I + + L LR + R ++ + Sbjct: 145 QTLDLSNTHIGLPYTINFSNLTQLR-----------QPSGPMRSIRRTQQ---------A 184 Query: 390 PVPFERDTVWRMRRKLRLYNNAGLCVNRDSDLDDAFGSKSGSTVRLCDAE 439 P P + T + +L +N+ ++ + L +KS V + + Sbjct: 185 PYPLVKLTPQQA---NQLKSNSASVSSQYNTLPKLGDTKSLHRVPMTRQQ 231 >5UOT-0 nrPDB Length = 619 Score = 29.4 bits (64), Expect = 3.8, Method: Composition-based stats. Identities = 20/115 (17%), Positives = 39/115 (33%), Gaps = 8/115 (6%) Query: 51 GARTEPD--EQDAVYDIMRATGNDWAAAIPDVCRGRWHGIECMPDQDNVYHVVSLSFGAL 108 G T+PD ++ +M N + + ++C Q+ + SL+ Sbjct: 199 GILTKPDLMDRGTEKSVMNVVRNLTYP-----LKKGYMIVKCRGQQEITNRL-SLAEATK 252 Query: 109 SDDTAFPTCDPQRSYVSESLTRLKHLKALFFYRCLGRAPQRIPAFLGRLGSSLQT 163 + T F T R + E + L + + +P G++ S Q Sbjct: 253 KEITFFQTHPYFRVLLEEGSATVPRLAERLTTELIMHIQKSLPLLEGQIRESHQK 307 >1PU7-A nrPDB Length = 218 Score = 28.6 bits (62), Expect = 6.1, Method: Composition-based stats. Identities = 24/117 (20%), Positives = 36/117 (30%), Gaps = 16/117 (13%) Query: 200 PLSFNRFSGLRSLDLSGNRLTGSIPGFV-LPALSVLDLNQNLLTGPVPPTLTSCGSLIKI 258 SF L+SLDL N P + AL L QN V +L + + + Sbjct: 2 LDSFEILKALKSLDLLKNAPAWWWPNALKFEALLGAVLTQNTKFEAVLKSLENLKNAFIL 61 Query: 259 ------------DLSRNRVT-GPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNS 302 + +++ P L+DLS N L S + Sbjct: 62 ENDDEINLKKIAYIEFSKLAECVRPSGFYNQKAKRLIDLSGNILKDF--QSFENFKQ 116 >5X7V-A nrPDB Length = 193 Score = 28.6 bits (62), Expect = 6.8, Method: Composition-based stats. Identities = 11/28 (39%), Positives = 15/28 (53%) Query: 261 SRNRVTGPIPESINRLNQLVLLDLSYNR 288 ++ +PE I+ LN LV LDL N Sbjct: 58 KHPALSDIVPEDIDILNHLVKLDLKDNM 85 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.311 0.124 0.305 Lambda K H 0.267 0.0384 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 15,821,214 Number of Sequences: 36641 Number of extensions: 589513 Number of successful extensions: 4001 Number of sequences better than 10.0: 84 Number of HSP's better than 10.0 without gapping: 92 Number of HSP's successfully gapped in prelim test: 41 Number of HSP's that attempted gapping in prelim test: 1397 Number of HSP's gapped (non-prelim): 529 length of query: 496 length of database: 10,336,785 effective HSP length: 101 effective length of query: 395 effective length of database: 6,636,044 effective search space: 2621237380 effective search space used: 2621237380 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.4 bits) S2: 61 (28.2 bits)