BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q9SMT7 (514 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 5IE2-A nrPDB 1053 0.0 3R44-A nrPDB 228 3e-60 5BUS-A nrPDB 219 3e-57 4FUQ-A nrPDB 216 2e-56 3IVR-A nrPDB 207 1e-53 3A9U-A nrPDB 189 4e-48 5BSW-A nrPDB 181 5e-46 3TSY-A nrPDB 179 2e-45 2D1S-A nrPDB 175 4e-44 3DLP-X nrPDB 167 8e-42 4WV3-A nrPDB 167 8e-42 3ETC-A nrPDB 166 2e-41 4M46-A nrPDB 163 2e-40 5DWV-A nrPDB 157 1e-38 2V7B-A nrPDB 154 8e-38 1MDF-A nrPDB 151 6e-37 4EAT-A nrPDB 151 8e-37 3O84-A nrPDB 145 4e-35 3RG2-A nrPDB 142 5e-34 3IPL-A nrPDB 138 5e-33 3GPC-A nrPDB 134 1e-31 5JRH-A nrPDB 133 1e-31 1RY2-A nrPDB 133 2e-31 1V25-A nrPDB 132 3e-31 5ES6-A nrPDB 128 7e-30 5ES8-A nrPDB 128 7e-30 5U29-A nrPDB 118 5e-27 4LGC-A nrPDB 117 1e-26 5JNF-C nrPDB 102 3e-22 3PBK-A nrPDB 99 5e-21 3E7W-A nrPDB 97 2e-20 4R0M-B nrPDB 92 4e-19 5EY8-A nrPDB 91 1e-18 3FCE-A nrPDB 89 5e-18 3L8C-A nrPDB 83 2e-16 3LNV-A nrPDB 79 5e-15 5D6N-A nrPDB 78 1e-14 6NJ0-A nrPDB 77 2e-14 5HM3-A nrPDB 75 5e-14 5EY9-A nrPDB 69 6e-12 5WMM-A nrPDB 66 3e-11 3E53-A nrPDB 65 7e-11 4GR5-A nrPDB 62 8e-10 4GR4-A nrPDB 55 7e-08 4WD1-A nrPDB 39 0.004 3NT2-A nrPDB 33 0.32 4F7G-B nrPDB 30 2.2 1LMI-A nrPDB 29 4.7 3FEW-X nrPDB 29 5.5 6EDI-A nrPDB 28 8.4 >5IE2-A nrPDB Length = 514 Score = 1053 bits (2722), Expect = 0.0, Method: Compositional matrix adjust. Identities = 514/514 (100%), Positives = 514/514 (100%) Query: 1 MDSDTLSGLLENVAKKFPDRRALSVSGKFNLTHARLHDLIERAASRLVSDAGIKPGDVVA 60 MDSDTLSGLLENVAKKFPDRRALSVSGKFNLTHARLHDLIERAASRLVSDAGIKPGDVVA Sbjct: 1 MDSDTLSGLLENVAKKFPDRRALSVSGKFNLTHARLHDLIERAASRLVSDAGIKPGDVVA 60 Query: 61 LTFPNTVEFVIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSKEGNAPAQEA 120 LTFPNTVEFVIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSKEGNAPAQEA Sbjct: 61 LTFPNTVEFVIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSKEGNAPAQEA 120 Query: 121 ASKLKISHVTATLLDAGSDLVLSVADSDSVVDSATELVNHPDDGALFLHTSGTTSRPKGV 180 ASKLKISHVTATLLDAGSDLVLSVADSDSVVDSATELVNHPDDGALFLHTSGTTSRPKGV Sbjct: 121 ASKLKISHVTATLLDAGSDLVLSVADSDSVVDSATELVNHPDDGALFLHTSGTTSRPKGV 180 Query: 181 PLTQLNLASSVKNIKAVYKLTESDSTVIVLPLFHVHGLLAGLLSSLGAGAAVTLPAAGRF 240 PLTQLNLASSVKNIKAVYKLTESDSTVIVLPLFHVHGLLAGLLSSLGAGAAVTLPAAGRF Sbjct: 181 PLTQLNLASSVKNIKAVYKLTESDSTVIVLPLFHVHGLLAGLLSSLGAGAAVTLPAAGRF 240 Query: 241 SATTFWPDMKKYNATWYTAVPTIHQIILDRHASHPETEYPKLRFIRSCSASLAPVILSRL 300 SATTFWPDMKKYNATWYTAVPTIHQIILDRHASHPETEYPKLRFIRSCSASLAPVILSRL Sbjct: 241 SATTFWPDMKKYNATWYTAVPTIHQIILDRHASHPETEYPKLRFIRSCSASLAPVILSRL 300 Query: 301 EEAFGAPVLEAYAMTEATHLMSSNPLPEEGPHKPGSVGKPVGQEMAILNEKGEIQEPNNK 360 EEAFGAPVLEAYAMTEATHLMSSNPLPEEGPHKPGSVGKPVGQEMAILNEKGEIQEPNNK Sbjct: 301 EEAFGAPVLEAYAMTEATHLMSSNPLPEEGPHKPGSVGKPVGQEMAILNEKGEIQEPNNK 360 Query: 361 GEVCIRGPNVTKGYKNNPEANKAGFEFGWFHTGDIGYFDTDGYLHLVGRIKELINRGGEK 420 GEVCIRGPNVTKGYKNNPEANKAGFEFGWFHTGDIGYFDTDGYLHLVGRIKELINRGGEK Sbjct: 361 GEVCIRGPNVTKGYKNNPEANKAGFEFGWFHTGDIGYFDTDGYLHLVGRIKELINRGGEK 420 Query: 421 ISPIEVDAVLLTHPDVSQGVAFGVPDEKYGEEINCAVIPREGTTVTEEDIKAFCKKNLAA 480 ISPIEVDAVLLTHPDVSQGVAFGVPDEKYGEEINCAVIPREGTTVTEEDIKAFCKKNLAA Sbjct: 421 ISPIEVDAVLLTHPDVSQGVAFGVPDEKYGEEINCAVIPREGTTVTEEDIKAFCKKNLAA 480 Query: 481 FKVPKRVFITDNLPKTASGKIQRRIVAQHFLEKP 514 FKVPKRVFITDNLPKTASGKIQRRIVAQHFLEKP Sbjct: 481 FKVPKRVFITDNLPKTASGKIQRRIVAQHFLEKP 514 >3R44-A nrPDB Length = 517 Score = 228 bits (582), Expect = 3e-60, Method: Compositional matrix adjust. Identities = 154/492 (31%), Positives = 256/492 (52%), Gaps = 26/492 (5%) Query: 26 SGKFNLTHARLHDLIERAASRLVSDAGIKPGDVVALTFPNTVEFVIMFLAVIRARATAAP 85 S +T+A+++ L R A L + GI GD VAL PN+VEF +F + A A P Sbjct: 39 STDVRMTYAQMNALANRCADVLTA-LGIAKGDRVALLMPNSVEFCCLFYGAAKLGAVAVP 97 Query: 86 LNAAYTAEEFEFYLSDSDSKLLLTSKEGNAPAQEAASKLKI-SHVTATLLD-AGSDLVLS 143 +N A E F LSDS SK+++ AP+ ++ + T+ D G+D + Sbjct: 98 INTRLAAPEVSFILSDSGSKVVIY----GAPSAPVIDAIRAQADPPGTVTDWIGADSLAE 153 Query: 144 VADSDSVVDSATELVNHPDDGALFLHTSGTTSRPKGVPLTQLNLASSVKNIKAVYKLTES 203 S + + A E DD ++TSGTT PKGV T ++ S+ + + + Sbjct: 154 RLRSAAADEPAVECGG--DDNLFIMYTSGTTGHPKGVVHTHESVHSAASSWASTIDVRYR 211 Query: 204 DSTVIVLPLFHVHGLLAGLLSSLGAGAAVTLPAAGRFSATTFWPDMKKYNATWYTAVPTI 263 D ++ LP+FHV L + S++ +++P +F AT W + + AVP I Sbjct: 212 DRLLLPLPMFHVAALTTVIFSAMRGVTLISMP---QFDATKVWSLIVEERVCIGGAVPAI 268 Query: 264 HQIILDRHASHPETEYPKLRFIRSCSASLAPVILSRLEEAFGAPVLEAYAMTEA----TH 319 + + E + P R+ + A + P L ++ A V++ YA+TE+ T Sbjct: 269 LNF-MRQVPEFAELDAPDFRYFITGGAPM-PEALIKIYAAKNIEVVQGYALTESCGGGTL 326 Query: 320 LMSSNPLPEEGPHKPGSVGKP-VGQEMAILNEKGEIQEPNNKGEVCIRGPNVTKGYKNNP 378 L+S + L K GS G+ + ++A+ + G I+E + +GEV I+ + K Y N P Sbjct: 327 LLSEDAL-----RKAGSAGRATMFTDVAVRGDDGVIRE-HGEGEVVIKSDILLKEYWNRP 380 Query: 379 EANKAGFEFGWFHTGDIGYFDTDGYLHLVGRIKELINRGGEKISPIEVDAVLLTHPDVSQ 438 EA + F+ GWF TGDIG D +GYL++ R+K++I GGE + P E+++V++ P VS+ Sbjct: 381 EATRDAFDNGWFRTGDIGEIDDEGYLYIKDRLKDMIISGGENVYPAEIESVIIGVPGVSE 440 Query: 439 GVAFGVPDEKYGEEINCAVIPREGTTVTEEDIKAFCKKNLAAFKVPKRVFITDNLPKTAS 498 G+PDEK+G EI A++ + V+E+ I +C LA +K+PK+V + +P+ + Sbjct: 441 VAVIGLPDEKWG-EIAAAIVVADQNEVSEQQIVEYCGTRLARYKLPKKVIFAEAIPRNPT 499 Query: 499 GKIQRRIVAQHF 510 GKI + ++ + + Sbjct: 500 GKILKTVLREQY 511 >5BUS-A nrPDB Length = 494 Score = 219 bits (557), Expect = 3e-57, Method: Compositional matrix adjust. Identities = 159/496 (32%), Positives = 244/496 (49%), Gaps = 32/496 (6%) Query: 10 LENVAKKFPDRRALSVSGKFNLTHARLHDLIERAASRLVSDAGIKPGDVVALTFPNTVEF 69 L A+ P+R AL + +T A L +R A +L + + ++ GD A+ N E Sbjct: 11 LMQRAQLTPERIALIYEDQ-TVTFAELFAASKRMAEQLAAHS-VRKGDTAAILLQNRAEM 68 Query: 70 VIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSKEGNAPAQEAASKLKISHV 129 V A A LN + E F L DS S LLT + K + H+ Sbjct: 69 VYAVHACFLLGVKAVLLNTKLSTHERLFQLEDSGSGFLLTDS--------SFEKKEYEHI 120 Query: 130 TATLLDAGSDLVLSVADSDSVVDSATELVNHPDDGALFLHTSGTTSRPKGVPLTQLNLAS 189 T+ D ++ A + +++ ++ D A ++TSGTT +PKGV T N Sbjct: 121 VQTI---DVDELMKEAAEEIEIEAYMQM----DATATLMYTSGTTGKPKGVQQTFGNHYF 173 Query: 190 SVKNIKAVYKLTESDSTVIVLPLFHVHGLLAGLLSSLGAGAAVTLPAAGRFSATTFWPDM 249 S + +TE D +I LPLFH+ GL + L S+ G V L RFS + + Sbjct: 174 SAVSSALNLGITEQDRWLIALPLFHISGL-SALFKSVIYGMTVVLHQ--RFSVSDVLHSI 230 Query: 250 KKYNATWYTAVPTIHQIILDRHASHPETEYPKLRFIRSCSASLAPVILSRLEEAF--GAP 307 ++ T +AV T+ +L+ PE+ IR P L LEE G P Sbjct: 231 NRHEVTMISAVQTMLASLLEETNRCPES-------IRCILLGGGPAPLPLLEECREKGFP 283 Query: 308 VLEAYAMTEATHLMSSNPLPEEGPHKPGSVGKPVGQEMAILNEKGEIQEPNNKGEVCIRG 367 V ++Y MTE + + PE K GS GKP+ + G++ EP GE+ ++G Sbjct: 284 VFQSYGMTETCSQIVTLS-PEFSMEKLGSAGKPLFSCEIKIERDGQVCEPYEHGEIMVKG 342 Query: 368 PNVTKGYKNNPEANKAGFEFGWFHTGDIGYFDTDGYLHLVGRIKELINRGGEKISPIEVD 427 PNV K Y N AN+A F+ GW TGD+GY D +G+L+++ R +LI GGE I P EV+ Sbjct: 343 PNVMKSYFNRESANEASFQNGWLKTGDLGYLDNEGFLYVLDRRSDLIISGGENIYPAEVE 402 Query: 428 AVLLTHPDVSQGVAFGVPDEKYGEEINCAVIPREGTTVTEEDIKAFCKKNLAAFKVPKRV 487 +VLL+HP V++ G D+K+G+ + ++ + V+ ++ +CK+ LA +K+P + Sbjct: 403 SVLLSHPAVAEAGVSGAEDKKWGKVPHAYLVLHK--PVSAGELTDYCKERLAKYKIPAKF 460 Query: 488 FITDNLPKTASGKIQR 503 F+ D LP+ AS K+ R Sbjct: 461 FVLDRLPRNASNKLLR 476 >4FUQ-A nrPDB Length = 503 Score = 216 bits (550), Expect = 2e-56, Method: Compositional matrix adjust. Identities = 155/498 (31%), Positives = 253/498 (50%), Gaps = 20/498 (4%) Query: 18 PDRRALSVSGKFNLTHARLHDLIERAASRLVSDAGIKPGDVVALTFPNTVEFVIMFLAVI 77 P + A+ + +++A L R A+ LV+ G++ GD VA +VE ++++LA + Sbjct: 16 PHKLAIETAAGDKISYAELVARAGRVANVLVA-RGLQVGDRVAAQTEKSVEALVLYLATV 74 Query: 78 RARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSKEGNAPAQEAASKLKISHVTATLLDAG 137 RA PLN AYT E +++++D++ K+++ P++ + V AT+ G Sbjct: 75 RAGGVYLPLNTAYTLHELDYFITDAEPKIVVCD-----PSKRDGIAAIAAKVGATVETLG 129 Query: 138 SDLVLSVADSDSVVDSATELVNH-PDDGALFLHTSGTTSRPKGVPLTQLNLASSVKNIKA 196 D S+ D+ + A ++ DD A L+TSGTT R KG L+ NLAS+ + Sbjct: 130 PDGRGSLTDAAAGASEAFATIDRGADDLAAILYTSGTTGRSKGAMLSHDNLASNSLTLVD 189 Query: 197 VYKLTESDSTVIVLPLFHVHGL-LAGLLSSLGAGAAVTLPAAGRFSATTFWPDMKKYNAT 255 ++ T D + LP++H HGL +A ++ G+ + LP +F M + AT Sbjct: 190 YWRFTPDDVLIHALPIYHTHGLFVASNVTLFARGSMIFLP---KFDPDKILDLMAR--AT 244 Query: 256 WYTAVPTIHQIILDRHASHPETEYPKLRFIRSCSASLAPVILSRLEEAFGAPVLEAYAMT 315 VPT + +L ET +R S SA L G VLE Y MT Sbjct: 245 VLMGVPTFYTRLLQSPRLTKETT-GHMRLFISGSAPLLADTHREWSAKTGHAVLERYGMT 303 Query: 316 EATHLMSSNPLPEEGPHKPGSVGKPV-GQEMAILN-EKGEIQEPNNKGEVCIRGPNVTKG 373 E T++ +SNP +G PG+VG + G + + E G+ + G + ++GPNV KG Sbjct: 304 E-TNMNTSNPY--DGDRVPGAVGPALPGVSARVTDPETGKELPRGDIGMIEVKGPNVFKG 360 Query: 374 YKNNPEANKAGF-EFGWFHTGDIGYFDTDGYLHLVGRIKELINRGGEKISPIEVDAVLLT 432 Y PE K+ F + G+F TGD+G D GY+H++GR K+L+ GG + P E+++ + Sbjct: 361 YWRMPEKTKSEFRDDGFFITGDLGKIDERGYVHILGRGKDLVITGGFNVYPKEIESEIDA 420 Query: 433 HPDVSQGVAFGVPDEKYGEEINCAVIPREGTTVTEEDIKAFCKKNLAAFKVPKRVFITDN 492 P V + GVP +GE + V+ +G T+ E + LA FK+PK+V D+ Sbjct: 421 MPGVVESAVIGVPHADFGEGVTAVVVRDKGATIDEAQVLHGLDGQLAKFKMPKKVIFVDD 480 Query: 493 LPKTASGKIQRRIVAQHF 510 LP+ GK+Q+ ++ + + Sbjct: 481 LPRNTMGKVQKNVLRETY 498 >3IVR-A nrPDB Length = 509 Score = 207 bits (526), Expect = 1e-53, Method: Compositional matrix adjust. Identities = 157/516 (30%), Positives = 235/516 (45%), Gaps = 41/516 (7%) Query: 5 TLSGLLENVAKKFPDRRALSVSGKFNLTHARLHDLIERAASRLVSDAGIKPGDVVALTFP 64 TL+ + A FPDR A V G LTH ER AS L+ D G+ GD VA+ Sbjct: 7 TLADVYRRNAALFPDRTAFMVDG-VRLTHRDYLARAERLASGLLRD-GVHTGDRVAILSQ 64 Query: 65 NTVEFVIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSKE------GNAPAQ 118 N E + + AV A P+N A+E F L D +++ + G P+ Sbjct: 65 NCSEMIELIGAVALIGAILLPVNYRLNADEIAFVLGDGAPSVVVAGTDYRDIVAGVLPSL 124 Query: 119 EAASKLKI----SHVTATLLDAGSDLVLSVADSDSVVDSATELVNHPDDGALFLHTSGTT 174 K S A D SD S + + DG + +HT+ Sbjct: 125 GGVKKAYAIGDGSGPFAPFKDLASDTPFSAPEFGAA------------DGFVIIHTAAVG 172 Query: 175 SRPKGVPLTQLNLASSVKNIKAVYKLTESDSTVIVLPLFHVHGLLAGLLSSLGAGAAVTL 234 RP+G ++Q NL + ++ ++LTE+D + +LPLFHV GL GL+ +L ++ Sbjct: 173 GRPRGALISQGNLLIAQSSLVDAWRLTEADVNLGMLPLFHVTGL--GLMLTLQQAGGASV 230 Query: 235 PAAGRFSATTFWPDMKKYNATWYTAVPTIHQIILDRHASHPETEYPKLRFIRSCSASLAP 294 AA +F D++ + T + ILD+ A +L +R+ + P Sbjct: 231 IAA-KFDPAQAARDIEAHKVTVMAEFAPMLGNILDQAAP------AQLASLRAVTGLDTP 283 Query: 295 VILSRLEEAF-GAPVLEAYAMTEATHLMSSNPLPEEGPHKPGSVGKPV-GQEMAILNEKG 352 + R E A + +E + L + P + +P S G+P+ + +A+++ + Sbjct: 284 ETIERFEATCPNATFWATFGQSETSGLSTFAPYRD----RPKSAGRPLFWRTVAVVDAED 339 Query: 353 EIQEPNNKGEVCIRGPNVTKGYKNNPEANKAGFEFGWFHTGDIGYFDTDGYLHLVGRI-- 410 P GE+ +RGP V KGY NN A + F GW HTGD+G FD DGYL GR Sbjct: 340 RPLPPGEVGEIVLRGPTVFKGYWNNAAATQHAFRNGWHHTGDMGRFDADGYLFYAGRAPE 399 Query: 411 KELINRGGEKISPIEVDAVLLTHPDVSQGVAFGVPDEKYGEEINCAVIPREGTTVTEEDI 470 KELI GGE + P EV+ L HP ++ V GVPD ++ E I + + G ++ + + Sbjct: 400 KELIKTGGENVYPAEVEGALKQHPAIADAVVIGVPDPQWSEAIKAVCVCKPGESIAADAL 459 Query: 471 KAFCKKNLAAFKVPKRVFITDNLPKTASGKIQRRIV 506 F +A +K PK V + LPK A G I R V Sbjct: 460 AEFVASLIARYKKPKHVVFVEALPKDAKGAIDRAAV 495 >3A9U-A nrPDB Length = 536 Score = 189 bits (479), Expect = 4e-48, Method: Compositional matrix adjust. Identities = 160/490 (32%), Positives = 242/490 (49%), Gaps = 30/490 (6%) Query: 32 THARLHDLIERAASRLVSDAGIKPGDVVALTFPNTVEFVIMFLAVIRARATAAPLNAAYT 91 T+A + R AS L + GI+ GDV+ L P++ EFV+ FL A N T Sbjct: 51 TYADVELTARRVASGL-NKIGIQQGDVIMLFLPSSPEFVLAFLGASHRGAIITAANPFST 109 Query: 92 AEEFEFYLSDSDSKLLLTSKEGNAPAQEAASKLKISHVTATLLDAGSDLVLSVAD-SDSV 150 E + S +KLL+T ++ A + S V +D+ D L ++ + + Sbjct: 110 PAELAKHAKASRAKLLITQACYYEKVKDFARE---SDVKVMCVDSAPDGCLHFSELTQAD 166 Query: 151 VDSATELVNHPDDGALFLHTSGTTSRPKGVPLTQLNLASSVK-----NIKAVYKLTESDS 205 + A ++ PDD ++SGTT PKGV LT L +SV + +Y +E D Sbjct: 167 ENEAPQVDISPDDVVALPYSSGTTGLPKGVMLTHKGLITSVAQQVDGDNPNLYFHSE-DV 225 Query: 206 TVIVLPLFHVHGLLAGLLSSLGAGAAVTLPAAGRFSATTFWPDMKKYNATWYTAVPTIHQ 265 + VLP+FH++ L + +L L GA + + +F + ++KY + VP + Sbjct: 226 ILCVLPMFHIYALNSIMLCGLRVGAPILI--MPKFEIGSLLGLIEKYKVSIAPVVPPVMM 283 Query: 266 II-----LDRHASHPETEYPKLRFIRSCSASLAPVILSRLEEAFGAPVL-EAYAMTEATH 319 I LD+H + LR I+S A L + + F L + Y MTEA Sbjct: 284 SIAKSPDLDKH------DLSSLRMIKSGGAPLGKELEDTVRAKFPQARLGQGYGMTEAGP 337 Query: 320 LMSSNPLPEEGPH--KPGSVGKPV-GQEMAILN-EKGEIQEPNNKGEVCIRGPNVTKGYK 375 +++ + P KPG+ G V EM I++ E G N GE+CIRG + KGY Sbjct: 338 VLAMCLAFAKEPFDIKPGACGTVVRNAEMKIVDPETGASLPRNQPGEICIRGDQIMKGYL 397 Query: 376 NNPEANKAGFEF-GWFHTGDIGYFDTDGYLHLVGRIKELINRGGEKISPIEVDAVLLTHP 434 N+PEA + GW HTGDIGY D D L +V R+KELI G +++P E++A+L+ HP Sbjct: 398 NDPEATSRTIDKEGWLHTGDIGYIDDDDELFIVDRLKELIKYKGFQVAPAELEALLIAHP 457 Query: 435 DVSQGVAFGVPDEKYGEEINCAVIPREGTTVTEEDIKAFCKKNLAAFKVPKRVFITDNLP 494 ++S G+ DE GE V+ E + TE++IK + K + +K KRVF + +P Sbjct: 458 EISDAAVVGLKDEDAGEVPVAFVVKSEKSQATEDEIKQYISKQVIFYKRIKRVFFIEAIP 517 Query: 495 KTASGKIQRR 504 K SGKI R+ Sbjct: 518 KAPSGKILRK 527 >5BSW-A nrPDB Length = 541 Score = 181 bits (460), Expect = 5e-46, Method: Compositional matrix adjust. Identities = 166/518 (32%), Positives = 253/518 (48%), Gaps = 37/518 (7%) Query: 7 SGLLENVAKKFPDRRAL-SVSGKFNLTHARLHDLIERAASRLVSDAGIKPGDVVALTFPN 65 S EN+++ F R L + + K T+A + +L R + + GI+P D + + PN Sbjct: 29 SYCFENISE-FSSRPCLINGANKQIYTYADV-ELNSRKVAAGLHKQGIQPKDTIMILLPN 86 Query: 66 TVEFVIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSKEGNAPAQEAASKLK 125 + EFV F+ A + N +T E S +K+++T ++ A + Sbjct: 87 SPEFVFAFIGASYLGAISTMANPLFTPAEVVKQAKASSAKIIVTQACHVNKVKDYAFE-- 144 Query: 126 ISHVTATLLDAGSDLVLSVADSDSVVDSATE-----LVNHPDDGALFLHTSGTTSRPKGV 180 + V +D+ + L SV+ A E + PDD ++SGTT PKGV Sbjct: 145 -NDVKIICIDSAPEGCLHF----SVLTQANEHDIPEVEIQPDDVVALPYSSGTTGLPKGV 199 Query: 181 PLTQLNLASSVKNI-----KAVYKLTESDSTVIVLPLFHVHGLLAGLLSSLGAGAAVTLP 235 LT L +SV +Y +E D + VLPLFH++ L + LL L GAA+ + Sbjct: 200 MLTHKGLVTSVAQQVDGENPNLYIHSE-DVMLCVLPLFHIYSLNSVLLCGLRVGAAILI- 257 Query: 236 AAGRFSATTFWPDMKKYNATWYTAVPTIHQIILDRHASHPETEYPKLRFIRSCSASLAPV 295 +F +F +++Y T VP I I A P + L +R+ + AP Sbjct: 258 -MQKFDIVSFLELIQRYKVTIGPFVPPIVLAI----AKSPMVDDYDLSSVRTVMSGAAP- 311 Query: 296 ILSRLEEAF-----GAPVLEAYAMTEATHLMSSNPLPEEGPH-KPGSVGKPV-GQEMAIL 348 + LE+ A + + Y MTEA L +E K G+ G V EM I+ Sbjct: 312 LGKELEDTVRAKFPNAKLGQGYGMTEAGPLAMCLAFAKEPFEIKSGACGTVVRNAEMKIV 371 Query: 349 NEKGEIQEPNNK-GEVCIRGPNVTKGYKNNPEANKAGFEF-GWFHTGDIGYFDTDGYLHL 406 + K P N+ GE+CIRG + KGY N+PEA + GW +TGDIGY D D L + Sbjct: 372 DPKTGNSLPRNQSGEICIRGDQIMKGYLNDPEATARTIDKEGWLYTGDIGYIDDDDELFI 431 Query: 407 VGRIKELINRGGEKISPIEVDAVLLTHPDVSQGVAFGVPDEKYGEEINCAVIPREGTTVT 466 V R+KELI G +++P E++A+LL HP++S + DE+ GE V+ G+T+T Sbjct: 432 VDRLKELIKYKGFQVAPAELEALLLNHPNISDAAVVPMKDEQAGEVPVAFVVRSNGSTIT 491 Query: 467 EEDIKAFCKKNLAAFKVPKRVFITDNLPKTASGKIQRR 504 E+++K F K + +K KRVF D +PK+ SGKI R+ Sbjct: 492 EDEVKDFISKQVIFYKRIKRVFFVDAIPKSPSGKILRK 529 >3TSY-A nrPDB Length = 979 Score = 179 bits (455), Expect = 2e-45, Method: Compositional matrix adjust. Identities = 161/498 (32%), Positives = 242/498 (48%), Gaps = 38/498 (7%) Query: 32 THARLHDLIERAASRLVSDAGIKPGDVVALTFPNTVEFVIMFLAVIRARATAAPLNAAYT 91 T++ +H +I R + G+ DVV L PN EFV+ FLA ATA N +T Sbjct: 90 TYSDVH-VISRQIAANFHKLGVNQNDVVMLLLPNCPEFVLSFLAASFRGATATAANPFFT 148 Query: 92 AEEFEFYLSDSDSKLLLTSK---EGNAPAQ--EAASKLKISHVTATLLDAG----SDLVL 142 E S++KL++T + P Q + + I + + G ++L Sbjct: 149 PAEIAKQAKASNTKLIITEARYVDKIKPLQNDDGVVIVCIDDNESVPIPEGCLRFTELTQ 208 Query: 143 SVADSDSVVDSATELVNHPDDGALFLHTSGTTSRPKGVPLTQLNLASSV------KNIKA 196 S ++ V+DS E+ PDD ++SGTT PKGV LT L +SV +N Sbjct: 209 STTEASEVIDS-VEI--SPDDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNL 265 Query: 197 VYKLTESDSTVIVLPLFHVHGLLAGLLSSLGAGAAVTLPAAGRFSATTFWPDMKKYNATW 256 + D + VLP+FH++ L + +L L GAA+ + +F +++ T Sbjct: 266 YFH--SDDVILCVLPMFHIYALNSIMLCGLRVGAAILI--MPKFEINLLLELIQRCKVTV 321 Query: 257 YTAVPTIHQIILDRHASHPETEYPKLRFIRSCSASLAPVILSRLEEAFGAP-----VLEA 311 VP I I A ETE L IR + AP + LE+A A + + Sbjct: 322 APMVPPIVLAI----AKSSETEKYDLSSIRVVKSGAAP-LGKELEDAVNAKFPNAKLGQG 376 Query: 312 YAMTEATHL--MSSNPLPEEGPHKPGSVGKPV-GQEMAILN-EKGEIQEPNNKGEVCIRG 367 Y MTEA + MS E P K G+ G V EM I++ + G+ N GE+CIRG Sbjct: 377 YGMTEAGPVLAMSLGFAKEPFPVKSGACGTVVRNAEMKIVDPDTGDSLSRNQPGEICIRG 436 Query: 368 PNVTKGYKNNPEANKAGFEF-GWFHTGDIGYFDTDGYLHLVGRIKELINRGGEKISPIEV 426 + KGY NNP A + GW HTGDIG D D L +V R+KELI G +++P E+ Sbjct: 437 HQIMKGYLNNPAATAETIDKDGWLHTGDIGLIDDDDELFIVDRLKELIKYKGFQVAPAEL 496 Query: 427 DAVLLTHPDVSQGVAFGVPDEKYGEEINCAVIPREGTTVTEEDIKAFCKKNLAAFKVPKR 486 +A+L+ HPD++ + +E GE V+ + + ++E+D+K F K + +K + Sbjct: 497 EALLIGHPDITDVAVVAMKEEAAGEVPVAFVVKSKDSELSEDDVKQFVSKQVVFYKRINK 556 Query: 487 VFITDNLPKTASGKIQRR 504 VF T+++PK SGKI R+ Sbjct: 557 VFFTESIPKAPSGKILRK 574 >2D1S-A nrPDB Length = 548 Score = 175 bits (444), Expect = 4e-44, Method: Compositional matrix adjust. Identities = 143/478 (29%), Positives = 225/478 (47%), Gaps = 35/478 (7%) Query: 59 VALTFPNTVEFVIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSKEG---NA 115 +AL N EF I +A + AP N YT E L S ++ +SK+G Sbjct: 80 IALCSENCEEFFIPVIAGLFIGVGVAPTNEIYTLRELVHSLGISKPTIVFSSKKGLDKVI 139 Query: 116 PAQEAASKLKISHVTATLLDAGSDLVLSVADSDSVVDS-----------ATELVNHPDDG 164 Q+ + +K T +LD+ D D+ + T V+ + Sbjct: 140 TVQKTVTTIK----TIVILDSKVDY-RGYQCLDTFIKRNTPPGFQASSFKTVEVDRKEQV 194 Query: 165 ALFLHTSGTTSRPKGVPLTQLNLASSVKNIK-AVY--KLTESDSTVIVLPLFHVHGLLAG 221 AL +++SG+T PKGV LT N+ + + + +Y +++ + + V+P H G+ Sbjct: 195 ALIMNSSGSTGLPKGVQLTHENIVTRFSHARDPIYGNQVSPGTAVLTVVPFHHGFGMFT- 253 Query: 222 LLSSLGAGAAVTLPAAGRFSATTFWPDMKKYNATWYTAVPTIHQIILDRHASHPETEYPK 281 L L G V + +F TF ++ Y T VPT+ I L++ + + Sbjct: 254 TLGYLICGFRVVMLT--KFDEETFLKTLQDYKCTSVILVPTLFAI-LNKSELLNKYDLSN 310 Query: 282 LRFIRSCSASLAPVILSRLEEAFGAP-VLEAYAMTEATHLMSSNPLPEEGPHKPGSVGK- 339 L I S A L+ + + F P V + Y +TE T + P EG KPG+ GK Sbjct: 311 LVEIASGGAPLSKEVGEAVARRFNLPGVRQGYGLTETTSAIIITP---EGDDKPGASGKV 367 Query: 340 -PVGQEMAILNEKGEIQEPNNKGEVCIRGPNVTKGYKNNPEANKAGF-EFGWFHTGDIGY 397 P+ + I + + PN +GEVC++GP + KGY NNPEA K E GW HTGDIGY Sbjct: 368 VPLFKAKVIDLDTKKSLGPNRRGEVCVKGPMLMKGYVNNPEATKELIDEEGWLHTGDIGY 427 Query: 398 FDTDGYLHLVGRIKELINRGGEKISPIEVDAVLLTHPDVSQGVAFGVPDEKYGEEINCAV 457 +D + + +V R+K LI G ++ P E+++VLL HP + GVPD GE V Sbjct: 428 YDEEKHFFIVDRLKSLIKYKGYQVPPAELESVLLQHPSIFDAGVAGVPDPVAGELPGAVV 487 Query: 458 IPREGTTVTEEDIKAFCKKNLA-AFKVPKRVFITDNLPKTASGKIQRRIVAQHFLEKP 514 + G +TE+++ + ++ A ++ V D +PK +GKI R + + L+KP Sbjct: 488 VLESGKNMTEKEVMDYVASQVSNAKRLRGGVRFVDEVPKGLTGKIDGRAI-REILKKP 544 >3DLP-X nrPDB Length = 504 Score = 167 bits (424), Expect = 8e-42, Method: Compositional matrix adjust. Identities = 142/515 (27%), Positives = 228/515 (44%), Gaps = 24/515 (4%) Query: 4 DTLSGLLENVAKKFPDRRALSVSGK-FNLTHARLHDLIERAASRLVSDAGIKPGDVVALT 62 T++ +L A + PD AL+V + LTHA L +E A+RL +D G++P VA+ Sbjct: 2 QTVNEMLRRAATRAPDHCALAVPARGLRLTHAELRARVEAVAARLHAD-GLRPQQRVAVV 60 Query: 63 FPNTVEFVIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSKEGNAPAQEAAS 122 PN+ + VI LA+ R A A LN + E + + + A ++ A Sbjct: 61 APNSADVVIAILALHRLGAVPALLNPRLKSAELAELIKRGEMTAAVI-----AVGRQVAD 115 Query: 123 KLKISHVTATLLDAGSDLVLSVADSDSVVDSATELVNHPDDGALFLHTSGTTSRPKGVPL 182 + S A ++ G DLV + S + P A +TSGTT PK + Sbjct: 116 AIFQSGSGARIIFLG-DLVRD-GEPYSYGPPIEDPQREPAQPAFIFYTSGTTGLPKAAII 173 Query: 183 TQLNLASSVKNIKAVYKLTESDSTVIV--LPLFHVHGLLAGLLSSLGAGAAVTLPAAGRF 240 Q S V + L V++ +PL+HV G A L+++L T F Sbjct: 174 PQRAAESRVLFMSTQVGLRHGRHNVVLGLMPLYHVVGFFAVLVAALALDG--TYVVVEEF 231 Query: 241 SATTFWPDMKKYNATWYTAVPTIHQIILDRHASHPET-EYPKLRFIRSCSASLAPVILSR 299 +++ T A PT + A + + LR + A++ +L Sbjct: 232 RPVDALQLVQQEQVTSLFATPTHLDALAAAAAHAGSSLKLDSLRHVTFAGATMPDAVLET 291 Query: 300 LEEAFGAPVLEAYAMTEATHLMSSNPLPEEGPHKPGSVGKPVGQEMAILNEKGEIQEPNN 359 + + + Y TEA N L P + E+ I+ G + E Sbjct: 292 VHQHLPGEKVNIYGTTEAM-----NSLYMRQPKTGTEMAPGFFSEVRIVRIGGGVDEIVA 346 Query: 360 KGE----VCIRGPNVTKGYKNNPEANKAGFEFGWFHTGDIGYFDTDGYLHLVGRIKELIN 415 GE + + GY N P+A + GW+ T D+ + +G + ++GR+ ++I Sbjct: 347 NGEEGELIVAASDSAFVGYLNQPQATAEKLQDGWYRTSDVAVWTPEGTVRILGRVPDMII 406 Query: 416 RGGEKISPIEVDAVLLTHPDVSQGVAFGVPDEKYGEEINCAVIPREGTTVTEEDIKAFCK 475 GGE I P E++ VL T P V++ V G+ D+++G+ + V+PR G T++ + + FC+ Sbjct: 407 SGGENIHPSEIERVLGTAPGVTEVVVIGLADQRWGQSVTACVVPRLGETLSADALDTFCR 466 Query: 476 KN-LAAFKVPKRVFITDNLPKTASGKIQRRIVAQH 509 + LA FK PKR FI D LPK A K+ RR + Q Sbjct: 467 SSELADFKRPKRYFILDQLPKNALNKVLRRQLVQQ 501 >4WV3-A nrPDB Length = 529 Score = 167 bits (424), Expect = 8e-42, Method: Compositional matrix adjust. Identities = 125/462 (27%), Positives = 212/462 (45%), Gaps = 18/462 (3%) Query: 52 GIKPGDVVALTFPNTVEFVIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSK 111 G++ G+ V L ++ E+V F +++ A A +N E+E+ L D +++L+ + Sbjct: 56 GVRFGECVGLLTLDSAEWVTSFFGIVKLGAIAVGINTLLKPPEYEYILRDCRARVLIVHQ 115 Query: 112 EGNAPAQEAASKLKISHVTATLLDAGSDLVLSVADSDSVVDSATELV-NHPDDGALFLHT 170 E + L + + + + LS D + E +H +D ++ Sbjct: 116 EFLPLIESIRGNLPMLEHIVVIGEGPQEGYLSFNDWIRPQPTTLEAAQSHREDICSLNYS 175 Query: 171 SGTTSRPKGVPLTQLN--LASSVKNIKAVYKLTESDSTVIVLPLFHVHGLLAGLLSSLGA 228 SGTT PKG+P + L + + + V L ESD T + LF G L+ Sbjct: 176 SGTTGGPKGIPHAHKDYPLTAQLWGVN-VLGLRESDRTFALAKLFFTFGTGGNLIFPWYV 234 Query: 229 GAAVTL-PAAGRFSATTFWPDMKKYNATWYTAVPTIHQ--IILDRHASHPETEYPKLRFI 285 GA+ L P A R ++ + ++ T + PT + + L + H + LR Sbjct: 235 GASCVLFPGAARVASNVL-STISRFKPTIFYNAPTGYAAALALKDFSQH---DLSSLRLC 290 Query: 286 RSCSASLAPVILSRLEEAFGAPVLEAYAMTEATHLMSSNPLPEEGPHKPGSVGKPV-GQE 344 S S +L + +EA G +++ TE H+ SN G +PGS GKPV G E Sbjct: 291 VSASEALPAALWYAWKEATGVDIIDGIGCTENFHIFISN---RPGDIRPGSSGKPVEGYE 347 Query: 345 MAILNEKGEIQEPNNKGEVCIRGPNVTKGYKNNPEANKAGFEFGWFHTGDIGYFDTDGYL 404 + +++++G+ G V +R Y +N E ++ F+ W TGD + D DGY Sbjct: 348 LKLVDDEGKTVPAGEIGNVLLRSETAALSYWHNFEKSRQTFQGEWLATGDKYFVDADGYY 407 Query: 405 HLVGRIKELINRGGEKISPIEVDAVLLTHPDVSQGVAFGVPDEKYGEEINCAVIPREGTT 464 GR +++ GG +SP+EV++ L+ HP V + G PD+ + +I + Sbjct: 408 WHAGRSDDMLKVGGIWVSPVEVESTLIQHPAVQECAVIGCPDQSRLIKPKAFIILKPEQI 467 Query: 465 VTEEDIKAF---CKKNLAAFKVPKRVFITDNLPKTASGKIQR 503 +E I+ C + +AA+K P+ + LPKTA+GKIQR Sbjct: 468 PSEALIRQITDHCTEKMAAYKRPRWIEFVTELPKTATGKIQR 509 >3ETC-A nrPDB Length = 580 Score = 166 bits (420), Expect = 2e-41, Method: Compositional matrix adjust. Identities = 138/528 (26%), Positives = 233/528 (44%), Gaps = 51/528 (9%) Query: 9 LLENVAKKFPDRRALSVSGKFN----LTHARLHDLIERAASRLVSDAGIKPGDVVALTFP 64 +++ A+ P++ A+ + T L ++AA+ V GI GD V LT Sbjct: 61 VVDVYARDSPEKLAMIWCDDYGNEKIFTFKDLKYYSDKAANFFVK-HGIGKGDYVMLTLK 119 Query: 65 NTVEFVIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSKEGNAPAQ--EAAS 122 + +F L + + A A P + + + + K+++ E + P Q EA + Sbjct: 120 SRYDFWYCMLGLHKLGAIAVPATHMLKTRDIVYRIEKAGLKMIVCIAEDDVPEQVDEAHA 179 Query: 123 K-----LKISHVTATLLDAGSDLVLSVADSDSVVDSAT-ELVNHPDDGALFLHTSGTTSR 176 + LK + V +L+ D + +S + + T E+ +D L +SGT Sbjct: 180 ECGDIPLKKAKVGGDVLEGWIDFRKELEESSPIFERPTGEVSTKNEDICLVYFSSGTAGF 239 Query: 177 PKGV------PLTQLNLASSVKNIKAV---YKLTESDSTVIVLPLFHVHGLLAGLLSSLG 227 PK V PL + A +N++ Y + +S V L Sbjct: 240 PKMVEHDNTYPLGHILTAKYWQNVEDDGLHYTVADSGWGKCVW---------GKLYGQWI 290 Query: 228 AGAAVTLPAAGRFSATTFWPDMKKYNATWYTAVPTIHQIILDRHASHPETEYPKLRFIRS 287 AG AV + RF A KY T + A PTI++ ++ SH + L++ Sbjct: 291 AGCAVFVYDYDRFEAKNMLEKASKYGVTTFCAPPTIYRFLIKEDLSH--YNFSTLKYAVV 348 Query: 288 CSASLAPVILSRLEEAFGAPVLEAYAMTEATHLMSSNPLPEEGPHKPGSVGKPV-GQEMA 346 L P + +R E G ++E + TE +++ P E KPGS+GKP G ++ Sbjct: 349 AGEPLNPEVFNRFLEFTGIKLMEGFGQTETVVTIATFPWMEP---KPGSIGKPTPGYKIE 405 Query: 347 ILNEKGEIQEPNNKGEVCIRGPNVTKG--------YKNNPEANKAGFEFGWFHTGDIGYF 398 +++ G + E +GE+ I N +G Y +PE + + G++HTGD+ + Sbjct: 406 LMDRDGRLCEVGEEGEIVI---NTMEGKPVGLFVHYGKDPERTEETWHDGYYHTGDMAWM 462 Query: 399 DTDGYLHLVGRIKELINRGGEKISPIEVDAVLLTHPDVSQGVAFGVPDEKYGEEINCAVI 458 D DGYL VGR ++I G K+ P EV++ L+ HP V + GVPD G+ I ++ Sbjct: 463 DEDGYLWFVGRADDIIKTSGYKVGPFEVESALIQHPAVLECAITGVPDPVRGQVIKATIV 522 Query: 459 PREGTTVTE---EDIKAFCKKNLAAFKVPKRVFITDNLPKTASGKIQR 503 + T ++ +++ K A +K P+ + LPKT SGKI+R Sbjct: 523 LTKDYTPSDSLKNELQDHVKNVTAPYKYPRIIEFVPELPKTISGKIRR 570 >4M46-A nrPDB Length = 581 Score = 163 bits (413), Expect = 2e-40, Method: Compositional matrix adjust. Identities = 138/503 (27%), Positives = 224/503 (44%), Gaps = 39/503 (7%) Query: 30 NLTHARLHDLIERAASRLVSDAGIKPGDVVALTFPNTVEFVIMFLAVIRARATAAPLNAA 89 N+T++ ++ R A + G+ +A+ N+++F + + AP N Sbjct: 84 NITYSEYFEMACRLAETM-KRYGLGLQHHIAVCSENSLQFFMPVCGALFIGVGVAPTNDI 142 Query: 90 YTAEEFEFYLSDSDSKLLLTSKEGNAPAQEAASKLKISHVTATLLDAGSDLVLSVADSDS 149 Y E LS S ++ SK KL I +LD+ D + S Sbjct: 143 YNERELYNSLSISQPTIVFCSKRALQKILGVQKKLPIIQ-KIVILDSREDY-MGKQSMYS 200 Query: 150 VVDSA-----TELVNHPDD------GALFLHTSGTTSRPKGVPLTQLNLASSVKNIK-AV 197 ++S E PD AL +++SG+T PKGV LT N+ + + V Sbjct: 201 FIESHLPAGFNEYDYIPDSFDRETATALIMNSSGSTGLPKGVELTHKNICVRFSHCRDPV 260 Query: 198 Y--KLTESDSTVIVLPLFHVHGLLAGLLSSLGAGAAVTLPAAGRFSATTFWPDMKKYNAT 255 + ++ + + V+P H G+ L L G + L RF F ++ Y Sbjct: 261 FGNQIIPDTAILTVIPFHHGFGMFT-TLGYLTCGFRIVL--MYRFEEELFLRSLQDYKIQ 317 Query: 256 WYTAVPTIHQI-----ILDRHASHPETEYPKLRFIRSCSASLAPVILSRLEEAFGAP-VL 309 VPT+ ++D++ + L I S A LA + + + F P + Sbjct: 318 SALLVPTLFSFFAKSTLVDKY------DLSNLHEIASGGAPLAKEVGEAVAKRFKLPGIR 371 Query: 310 EAYAMTEATHLMSSNPLPEEGPHKPGSVGK--PVGQEMAILNEKGEIQEPNNKGEVCIRG 367 + Y +TE T + P EG KPG+ GK P + + G+ N +GE+C++G Sbjct: 372 QGYGLTETTSAIIITP---EGDDKPGACGKVVPFFSAKIVDLDTGKTLGVNQRGELCVKG 428 Query: 368 PNVTKGYKNNPEANKAGFEF-GWFHTGDIGYFDTDGYLHLVGRIKELINRGGEKISPIEV 426 P + KGY NNPEA A + GW H+GDI Y+D DG+ +V R+K LI G ++ P E+ Sbjct: 429 PMIMKGYVNNPEATSALIDKDGWLHSGDIAYYDKDGHFFIVDRLKSLIKYKGYQVPPAEL 488 Query: 427 DAVLLTHPDVSQGVAFGVPDEKYGEEINCAVIPREGTTVTEEDIKAFCKKNLAAFK-VPK 485 +++LL HP + G+PD GE V+ EG T+TE+++ + + A K + Sbjct: 489 ESILLQHPFIFDAGVAGIPDPDAGELPAAVVVLEEGKTMTEQEVMDYVAGQVTASKRLRG 548 Query: 486 RVFITDNLPKTASGKIQRRIVAQ 508 V D +PK +GKI R + + Sbjct: 549 GVKFVDEVPKGLTGKIDARKIRE 571 >5DWV-A nrPDB Length = 573 Score = 157 bits (396), Expect = 1e-38, Method: Compositional matrix adjust. Identities = 133/502 (26%), Positives = 225/502 (44%), Gaps = 37/502 (7%) Query: 30 NLTHARLHDLIERAASRLVSDAGIKPGDVVALTFPNTVEFVIMFLAVIRARATAAPLNAA 89 N+T+A ++ R A + G+ + + N+++F + L + AP N Sbjct: 73 NITYAEYFEMSVRLAEAM-KRYGLNTNHRIVVCSENSLQFFMPVLGALFIGVAVAPANDI 131 Query: 90 YTAEEFEFYLSDSDSKLLLTSKEGNAPAQEAASKLKISHVTATLLDAGSDL-----VLSV 144 Y E ++ S ++ SK+G KL I ++D+ +D + + Sbjct: 132 YNERELLNSMNISQPTVVFVSKKGLQKILNVQKKLPIIQ-KIIIMDSKTDYQGFQSMYTF 190 Query: 145 ADSD-----SVVDSATELVNHPDDGALFLHTSGTTSRPKGVPL---TQLNLASSVKNIKA 196 S + D E + AL +++SG+T PKGV L T S ++ Sbjct: 191 VTSHLPPGFNEYDFVPESFDRDKTIALIMNSSGSTGLPKGVALPHRTACVRFSHARDPIF 250 Query: 197 VYKLTESDSTVIVLPLFHVHGLLAGLLSSLGAGAAVTLPAAGRFSATTFWPDMKKYNATW 256 ++ + + V+P H G+ L L G V L RF F ++ Y Sbjct: 251 GNQIIPDTAILSVVPFHHGFGMFT-TLGYLICGFRVVL--MYRFEEELFLRSLQDYKIQS 307 Query: 257 YTAVPTIHQI-----ILDRHASHPETEYPKLRFIRSCSASLAPVILSRLEEAFGAP-VLE 310 VPT+ ++D++ + L I S A L+ + + + F P + + Sbjct: 308 ALLVPTLFSFFAKSTLIDKY------DLSNLHEIASGGAPLSKEVGEAVAKRFHLPGIRQ 361 Query: 311 AYAMTEATHLMSSNPLPEEGPHKPGSVGK--PVGQEMAILNEKGEIQEPNNKGEVCIRGP 368 Y +TE T + P EG KPG+VGK P + + + G+ N +GE+C+RGP Sbjct: 362 GYGLTETTSAILITP---EGDDKPGAVGKVVPFFEAKVVDLDTGKTLGVNQRGELCVRGP 418 Query: 369 NVTKGYKNNPEANKAGFEF-GWFHTGDIGYFDTDGYLHLVGRIKELINRGGEKISPIEVD 427 + GY NNPEA A + GW H+GDI Y+D D + +V R+K LI G +++P E++ Sbjct: 419 MIMSGYVNNPEATNALIDKDGWLHSGDIAYWDEDEHFFIVDRLKSLIKYKGYQVAPAELE 478 Query: 428 AVLLTHPDVSQGVAFGVPDEKYGEEINCAVIPREGTTVTEEDIKAFCKKNL-AAFKVPKR 486 ++LL HP++ G+PD+ GE V+ G T+TE++I + + A K+ Sbjct: 479 SILLQHPNIFDAGVAGLPDDDAGELPAAVVVLEHGKTMTEKEIVDYVASQVTTAKKLRGG 538 Query: 487 VFITDNLPKTASGKIQRRIVAQ 508 V D +PK +GK+ R + + Sbjct: 539 VVFVDEVPKGLTGKLDARKIRE 560 >2V7B-A nrPDB Length = 529 Score = 154 bits (389), Expect = 8e-38, Method: Compositional matrix adjust. Identities = 136/492 (27%), Positives = 218/492 (44%), Gaps = 38/492 (7%) Query: 32 THARLHDLIERAASRLVSDAGIKPGDVVALTFPNTVEFVIMFLAVIRARATAAPLNAAYT 91 T+ L + R AS L + G+ P + + L +TV + FL + A N T Sbjct: 50 TYGELEERARRFASALRT-LGVHPEERILLVMLDTVALPVAFLGALYAGVVPVVANTLLT 108 Query: 92 AEEFEFYLSDSDSKLLLTSKEGNAPAQEAASKLKISHVTATLLDA---GSDLVLSVADS- 147 ++ + L+ S ++ ++ AS + +VT L A G L++S Sbjct: 109 PADYVYMLTHSHARAVI------------ASGALVQNVTQALESAEHDGCQLIVSQPRES 156 Query: 148 ------------DSVVDSATELVNHPDDGALFLHTSGTTSRPKGVPLTQLNLASSVK-NI 194 D+ +A DD A +L++SG+T +PKG T NL + + Sbjct: 157 EPRLAPLFEELIDAAAPAAKAAATGCDDIAFWLYSSGSTGKPKGTVHTHANLYWTAELYA 216 Query: 195 KAVYKLTESDSTVIVLPLFHVHGLLAGLLSSLGAGAAVTLPAAGRFSATTFWPDMKKYNA 254 K + + E+D LF +GL GL L GA L A R +A + + ++ Sbjct: 217 KPILGIAENDVVFSAAKLFFAYGLGNGLTFPLSVGATAIL-MAERPTADAIFARLVEHRP 275 Query: 255 TWYTAVPTIHQIILDRHASHPETEYPKLRFIRSCSASLAPVILSRLEEAFGAPVLEAYAM 314 T + VPT++ +L + P +R S +L I R FG +L+ Sbjct: 276 TVFYGVPTLYANML-VSPNLPARADVAIRICTSAGEALPREIGERFTAHFGCEILDGIGS 334 Query: 315 TEATHLMSSNPLPEEGPHKPGSVGKPV-GQEMAILNEKGEIQEPNNKGEVCIRGPNVTKG 373 TE H+ SN G + G+ G+PV G E+ + +E G G++ I+GP+ Sbjct: 335 TEMLHIFLSN---RAGAVEYGTTGRPVPGYEIELRDEAGHAVPDGEVGDLYIKGPSAAVM 391 Query: 374 YKNNPEANKAGFEFGWFHTGDIGYFDTDGYLHLVGRIKELINRGGEKISPIEVDAVLLTH 433 Y NN E ++A F W +GD +G GR +++ G+ +SP+EV+ VL+ H Sbjct: 392 YWNNREKSRATFLGEWIRSGDKYCRLPNGCYVYAGRSDDMLKVSGQYVSPVEVEMVLVQH 451 Query: 434 PDVSQGVAFGVPDEKYGEEINCAVIPRE--GTTVTEEDIKAFCKKNLAAFKVPKRVFITD 491 V + GV + V+ RE + + E++KAF K LA K P+ + D Sbjct: 452 DAVLEAAVVGVDHGGLVKTRAFVVLKREFAPSEILAEELKAFVKDRLAPHKYPRDIVFVD 511 Query: 492 NLPKTASGKIQR 503 +LPKTA+GKIQR Sbjct: 512 DLPKTATGKIQR 523 >1MDF-A nrPDB Length = 539 Score = 151 bits (382), Expect = 6e-37, Method: Compositional matrix adjust. Identities = 146/527 (27%), Positives = 236/527 (44%), Gaps = 36/527 (6%) Query: 4 DTLSGLLENVAKKFPDRRALSVSGKFNLTHARLHDLIERAASRLVS---DAGIKPGDVVA 60 +T LL + A K+ DR A++ TH +L RA RL + GI+ D V Sbjct: 25 ETFGDLLRDRAAKYGDRIAITCGN----THWSYRELDTRA-DRLAAGFQKLGIQQKDRVV 79 Query: 61 LTFPNTVEFVIMFLAVIRARATAAPLNAAYTAEEFEFY--LSDSDSKLLLTSKEG---NA 115 + PN EF + A+ R A ++ + E ++ +++ + ++ + G + Sbjct: 80 VQLPNIKEFFEVIFALFRLGALPVFALPSHRSSEITYFCEFAEAAAYIIPDAYSGFDYRS 139 Query: 116 PAQEAASKLKISHVTATLLDAGSDLVLSVADSDSVVDSATELVNHPD----DGALFLHTS 171 A++ SKL +A L L D TE V P+ D A + Sbjct: 140 LARQVQSKLPTLKNIIVAGEAEEFLPLE--------DLHTEPVKLPEVKSSDVAFLQLSG 191 Query: 172 GTTSRPKGVPLTQLNLASSVKNIKAVYKLTESDSTVIVLPLFHVHGLLA-GLLSSLGAGA 230 G+T K +P T + S+K V L S + LP+ H + L + G+L L AG Sbjct: 192 GSTGLSKLIPRTHDDYIYSLKRSVEVCWLDHSTVYLAALPMAHNYPLSSPGVLGVLYAGG 251 Query: 231 AVTLPAAGRFSATTFWPDMKKYNATWYTAVPTIHQIILDRHASHPETEYPKLRFIRSCSA 290 V L + S +P +++ T VP + + +D AS + L+ ++ A Sbjct: 252 RVVLSPSP--SPDDAFPLIEREKVTITALVPPLAMVWMD-AASSRRDDLSSLQVLQVGGA 308 Query: 291 SLAPVILSRLEEAFGAPVLEAYAMTEATHLMSSNPLPEEGPHKPGSVGKPVG--QEMAIL 348 + R++ FG + + + M E + PEE + GKP+ E + Sbjct: 309 KFSAEAARRVKAVFGCTLQQVFGMAEGLVNYTRLDDPEE--IIVNTQGKPMSPYDESRVW 366 Query: 349 NEKGEIQEPNNKGEVCIRGPNVTKGYKNNPEANKAGF-EFGWFHTGDIGYFDTDGYLHLV 407 ++ +P G + RGP +GY E N A F E G++ TGDI DGY+ + Sbjct: 367 DDHDRDVKPGETGHLLTRGPYTIRGYYKAEEHNAASFTEDGFYRTGDIVRLTRDGYIVVE 426 Query: 408 GRIKELINRGGEKISPIEVDAVLLTHPDVSQGVAFGVPDEKYGEEINCAVIPREGTTVTE 467 GR K+ INRGGEK++ EV+ LL HP V +PD+ GE +IPR+ Sbjct: 427 GRAKDQINRGGEKVAAEEVENHLLAHPAVHDAAMVSMPDQFLGERSCVFIIPRDEAPKAA 486 Query: 468 EDIKAFCK-KNLAAFKVPKRVFITDNLPKTASGKIQRRIVAQHFLEK 513 E +KAF + + LAA+K+P RV ++ P+T GK+ ++ + + EK Sbjct: 487 E-LKAFLRERGLAAYKIPDRVEFVESFPQTGVGKVSKKALREAISEK 532 >4EAT-A nrPDB Length = 524 Score = 151 bits (381), Expect = 8e-37, Method: Compositional matrix adjust. Identities = 136/498 (27%), Positives = 214/498 (42%), Gaps = 21/498 (4%) Query: 18 PDRRALSVSGKFNLTHARLHDLIERAASRLVSDAGIKPGDVVALTFPNTVEFVIMFLAVI 77 PD+ A V +L+ A+L + A+ L + G+K + V L + ++ + FL I Sbjct: 27 PDKTAF-VDDISSLSFAQLEAQTRQLAAALRA-IGVKREERVLLLMLDGTDWPVAFLGAI 84 Query: 78 RARATAAPLNAAYTAEEFEFYLSDSDSKLLLTS-------KEGNAPAQEAASKLKISHVT 130 A +N TA+++ + L S ++ +L S K + ++ +S Sbjct: 85 YAGIVPVAVNTLLTADDYAYMLEHSRAQAVLVSGALHPVLKAALTKSDHEVQRVIVSRPA 144 Query: 131 ATLLDAGSDLVLSVADSDSVVDSATELVNHPDDGALFLHTSGTTSRPKGVPLTQLN-LAS 189 A L D V + A DD A +L++SG+T RPKGV T N + Sbjct: 145 APLEPGEVDFAEFVGAHAPLEKPA---ATQADDPAFWLYSSGSTGRPKGVVHTHANPYWT 201 Query: 190 SVKNIKAVYKLTESDSTVIVLPLFHVHGLLAGLLSSLGAGAAVTLPAAGRFSATTF--W- 246 S + L E D LF +GL L + GA L F W Sbjct: 202 SELYGRNTLHLREDDVCFSAAKLFFAYGLGNALTFPMTVGATTLLMGERPTPDAVFKRWL 261 Query: 247 PDMKKYNATWYTAVPTIHQIILDRHASHPETEYPKLRFIRSCSASLAPVILSRLEEAFGA 306 + T + PT + +L + P + LR S +L I R + FG Sbjct: 262 GGVGGVKPTVFYGAPTGYAGML-AAPNLPSRDQVALRLASSAGEALPAEIGQRFQRHFGL 320 Query: 307 PVLEAYAMTEATHLMSSNPLPEEGPHKPGSVGKPV-GQEMAILNEKGEIQEPNNKGEVCI 365 +++ TE H+ SN LP+ + G+ G PV G ++ + + G G++ I Sbjct: 321 DIVDGIGSTEMLHIFLSN-LPDR--VRYGTTGWPVPGYQIELRGDGGGPVADGEPGDLYI 377 Query: 366 RGPNVTKGYKNNPEANKAGFEFGWFHTGDIGYFDTDGYLHLVGRIKELINRGGEKISPIE 425 GP+ Y N ++ F+ GW +GD + DG GR +++ G +SP E Sbjct: 378 HGPSSATMYWGNRAKSRDTFQGGWTKSGDKYVRNDDGSYTYAGRTDDMLKVSGIYVSPFE 437 Query: 426 VDAVLLTHPDVSQGVAFGVPDEKYGEEINCAVIPREGTTVTEEDIKAFCKKNLAAFKVPK 485 ++A L+ HP V + GV DE + V+PR G T++E ++K F K LA +K P+ Sbjct: 438 IEATLVQHPGVLEAAVVGVADEHGLTKPKAYVVPRPGQTLSETELKTFIKDRLAPYKYPR 497 Query: 486 RVFITDNLPKTASGKIQR 503 LPKTA+GKIQR Sbjct: 498 STVFVAELPKTATGKIQR 515 >3O84-A nrPDB Length = 544 Score = 145 bits (367), Expect = 4e-35, Method: Compositional matrix adjust. Identities = 121/492 (24%), Positives = 234/492 (47%), Gaps = 21/492 (4%) Query: 25 VSGKFNLTHARLHDLIERAASRLVSDAGIKPGDVVALTFPNTVEFVIMFLAVIRARATAA 84 + G+ L++ L L A+RL ++ G+ GD + PN EF I+F A+++A Sbjct: 50 ICGERQLSYIELDRLSTNLATRL-AEKGLGKGDTALVQLPNVAEFYIVFFALLKAGVVV- 107 Query: 85 PLNAAYTAEEFEF--YLSDSDSKLLLTSKE----GNAPAQEAASKLKISHVTATLLDAGS 138 LNA Y+ ++E ++ KLL+ S++ N ++ + +S +L+ + Sbjct: 108 -LNALYSHRQYELNAFIKQIQPKLLIGSRQHEVFSNNQFIDSLHDVNLSPEIILMLNHQA 166 Query: 139 DLVLSVADSDSVVDSATELVNHP-DDGALFLHTSGTTSRPKGVPLTQLNLASSVKNIKAV 197 + ++ ++ + + P D+ A F + G+T PK +P T + SV+ + Sbjct: 167 TDFGLLDWIETPAETFVDFSSTPADEVAFFQLSGGSTGTPKLIPRTHNDYDYSVRASAEI 226 Query: 198 YKLTESDSTVIVLPLFHVHGLLA-GLLSSLGAGAAVTLPAAGRFSATTFWPDMKKYNATW 256 L + + LP H L + G L L AG V + A + ++++ Sbjct: 227 CGLNSNTRLLCALPAPHNFMLSSPGALGVLHAGGCVVM--APNPEPLNCFSIIQRHQVNM 284 Query: 257 YTAVPTIHQIILDRHASHPETEYPKLRFIRSCSASLAPVILSRLEEAFGAPVLEAYAMTE 316 + VP+ + L++ A + + + L+ ++ AS + ++ E + + + M E Sbjct: 285 ASLVPSAVIMWLEKAAQYKD-QIQSLKLLQVGGASFPESLARQVPEVLNCKLQQVFGMAE 343 Query: 317 ATHLMSSNPLPEEGPHKPGSVGKPVGQ--EMAILNEKGEIQEPNNKGEVCIRGPNVTKGY 374 L++ L + + G+P+ E+ I++E+ G + RGP GY Sbjct: 344 G--LVNYTRLDDSDEQIFTTQGRPISSDDEIKIVDEQYREVPEGEIGMLATRGPYTFCGY 401 Query: 375 KNNPEANKAGF-EFGWFHTGDIGYFDTDGYLHLVGRIKELINRGGEKISPIEVDAVLLTH 433 +PE N F E ++++GD+ DG L +VGRIK+ INRGGEKI+ E++ ++L H Sbjct: 402 YQSPEHNSQVFDEDNYYYSGDLVQRTPDGNLRVVGRIKDQINRGGEKIASEEIEKLILLH 461 Query: 434 PDVSQGVAFGVPDEKYGEEINCAVIPREGTTVTEEDIKA-FCKKNLAAFKVPKRVFITDN 492 P+V + DE++GE+ +CA I + ++ + +A +K+P ++ + ++ Sbjct: 462 PEVMHAALVAIVDEQFGEK-SCAFIVSRNPELKAVVLRRHLMELGIAQYKLPDQIKLIES 520 Query: 493 LPKTASGKIQRR 504 LP TA GK+ ++ Sbjct: 521 LPLTAVGKVDKK 532 >3RG2-A nrPDB Length = 617 Score = 142 bits (357), Expect = 5e-34, Method: Compositional matrix adjust. Identities = 125/503 (24%), Positives = 225/503 (44%), Gaps = 36/503 (7%) Query: 25 VSGKFNLTHARLHDLIERAASRLVSDAGIKPGDVVALTFPNTVEFVIMFLAVIRARATAA 84 + G+ L++ L+ + A L GIKPG+ + N E I F A+++ A Sbjct: 45 IDGERQLSYRELNQAADNLACSL-RRQGIKPGETALVQLGNVAELYITFFALLKL--GVA 101 Query: 85 PLNAAYTAEEFEF--YLSDSDSKLLLTSKEGNAPAQEAASKLKISHVTATLLDAGSDLVL 142 P+ A ++ + E Y S + LL+ ++ + T + S + + Sbjct: 102 PVLALFSHQRSELNAYASQIEPALLIADRQ--------HALFSGDDFLNTFVTEHSSIRV 153 Query: 143 SVADSDSVVDSATELVNHP-----------DDGALFLHTSGTTSRPKGVPLTQLNLASSV 191 +DS + + +NHP D+ A F + GTT PK +P T + SV Sbjct: 154 VQLLNDSGEHNLQDAINHPAEDFTATPSPADEVAYFQLSGGTTGTPKLIPRTHNDYYYSV 213 Query: 192 KNIKAVYKLTESDSTVIVLPLFHVHGLLA-GLLSSLGAGAAVTLPAAGRFSATTFWPDMK 250 + + + T+ + +P H + + + G L AG V L A SAT +P ++ Sbjct: 214 RRSVEICQFTQQTRYLCAIPAAHNYAMSSPGSLGVFLAGGTVVLAADP--SATLCFPLIE 271 Query: 251 KYNATWYTAVPTIHQIILDRH-ASHPETEYPKLRFIRSCSASLAPVILSRLEEAFGAPVL 309 K+ VP + L + L+ ++ A L+ + +R+ G + Sbjct: 272 KHQVNVTALVPPAVSLWLQALIEGESRAQLASLKLLQVGGARLSATLAARIPAEIGCQLQ 331 Query: 310 EAYAMTEATHLMSSNPLPEEGPHKPGSVGKPV--GQEMAILNEKGEIQEPNNKGEVCIRG 367 + + M E L++ L + + G P+ E+ + + +G G + RG Sbjct: 332 QVFGMAEG--LVNYTRLDDSAEKIIHTQGYPMCPDDEVWVADAEGNPLPQGEVGRLMTRG 389 Query: 368 PNVTKGYKNNPEANKAGFEF-GWFHTGDIGYFDTDGYLHLVGRIKELINRGGEKISPIEV 426 P +GY +P+ N + F+ G++ +GD+ D +GY+ + GR K+ INRGGEKI+ E+ Sbjct: 390 PYTFRGYYKSPQHNASAFDANGFYCSGDLISIDPEGYITVQGREKDQINRGGEKIAAEEI 449 Query: 427 DAVLLTHPDVSQGVAFGVPDEKYGEEINCAVIPREGTTVTEEDIKAFCK-KNLAAFKVPK 485 + +LL HP V + DE GE+ ++ +E + ++ F + + +A FK+P Sbjct: 450 ENLLLRHPAVIYAALVSMEDELMGEKSCAYLVVKEPLRAVQ--VRRFLREQGIAEFKLPD 507 Query: 486 RVFITDNLPKTASGKIQRRIVAQ 508 RV D+LP TA GK+ ++ + Q Sbjct: 508 RVECVDSLPLTAVGKVDKKQLRQ 530 >3IPL-A nrPDB Length = 501 Score = 138 bits (348), Expect = 5e-33, Method: Compositional matrix adjust. Identities = 129/462 (27%), Positives = 209/462 (45%), Gaps = 41/462 (8%) Query: 59 VALTFPNTVEFVIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSKEGNAPAQ 118 V L N+++ +I+ A A A +N T E + D +L+ + Sbjct: 51 VGLYIDNSIQSIILIHACWLANIEIAMINTRLTPNEMTNQMRSIDVQLIFCTLPLELRGF 110 Query: 119 EAASKLKISH-----VTATLLDAGSDLVLSVADSDSV-VDSATELVN---HPDDGALFLH 169 + S I T LLD + ++ V +S + ++N + DD A + Sbjct: 111 QIVSLDDIEFAGRDITTNGLLDNTMGIQYDTSNETVVPKESPSNILNTSFNLDDIASIMF 170 Query: 170 TSGTTSRPKGVPLTQLNLASSVKNIKAVYKLTESDSTVIVLPLFHVHGLLAGLLSSLGAG 229 TSGTT K VP T N +S K + + VLP++H+ GL + LL ++ G Sbjct: 171 TSGTTGPQKAVPQTFRNHYASAIGCKESLGFDRDTNWLSVLPIYHISGL-SVLLRAVIEG 229 Query: 230 AAVTLPAAGRFSATTFWPDMKKYNATWYTAVPTIHQIILDRHASHPETEYPKLRFIRSCS 289 V + +F+A +K T + VP ++ + P Y + + + Sbjct: 230 FTVRI--VDKFNAEQILTMIKNERITHISLVPQTLNWLMQQGLHEP---YNLQKILLGGA 284 Query: 290 ASLAPVILSRLEEAFGAPVLEAYAMTE-ATHLMSSNPLPEEGPHKPGSVGKPVGQEMAIL 348 A +I + L+ + P+ ++ MTE + +++ P E +P +VG P Sbjct: 285 KLSATMIETALQ--YNLPIYNSFGMTETCSQFLTATP--EMLHARPDTVGMPSA------ 334 Query: 349 NEKGEIQEPNNKG--EVCIRGPNVTKGYKNNPEANKAGFEFGWFHTGDIGYFDTDGYLHL 406 N +I+ PN +G E+ I+G NV GY P FE G+F+TGDI D +GY+ + Sbjct: 335 NVDVKIKNPNKEGHGELMIKGANVMNGYLY-PTDLTGTFENGYFNTGDIAEIDHEGYVMI 393 Query: 407 VGRIKELINRGGEKISPIEVDAVLLTHPDVSQGVAFGVPDEKYGEEINCAVIPREGTTVT 466 R K+LI GGE I P +++ V P +S V G PD+ +G+ +P+ V+ Sbjct: 394 YDRRKDLIISGGENIYPYQIETVAKQFPGISDAVCVGHPDDTWGQ------VPKL-YFVS 446 Query: 467 EEDIK-----AFCKKNLAAFKVPKRVFITDNLPKTASGKIQR 503 E DI A+ K+LA +KVPK D LP T++GK+QR Sbjct: 447 ESDISKAQLIAYLSKHLAKYKVPKHFEKVDTLPYTSTGKLQR 488 >3GPC-A nrPDB Length = 570 Score = 134 bits (336), Expect = 1e-31, Method: Compositional matrix adjust. Identities = 125/520 (24%), Positives = 213/520 (40%), Gaps = 42/520 (8%) Query: 10 LENVAKKFPDRRALSVSGKFNLTHARLHDLIE---RAASRLVSDAGIKPGDVVALTFPNT 66 +E K+ P V+GK +L E +AA+ L G++ GD VA+ P Sbjct: 50 MEKAGKRPPSPALWWVNGKGKELMWNFRELSENSQQAANVLSGACGLQRGDRVAVVLPRV 109 Query: 67 VEFVIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLLTS----KEGNAPAQEAAS 122 E+ ++ L IRA P + + + L S +K ++ +E + A E S Sbjct: 110 PEWWLVILGCIRAGLIFMPGTIQMKSTDILYRLQMSKAKAIVAGDEVIQEVDTVASECPS 169 Query: 123 ---KLKISHVTATLLDAGSDLVLSVADSDSVVDSATELVNHPDDGALFLHTSGTTSRPKG 179 KL +S + L+ + + V++ ++ + + TSGT+ PK Sbjct: 170 LRIKLLVSEKSCDGWLNFKKLLNEASTTHHCVETGSQ------EASAIYFTSGTSGLPKM 223 Query: 180 VPLTQLNLASSVKNIKAVYKLTESDSTVIVLPLFHVHGLLAGLLSSLGAGAAVTLPAAGR 239 + +L K L SD + + +L L+ GA + + Sbjct: 224 AEHSYSSLGLKAKMDAGWTGLQASDIMWTISDTGWILNILCSLMEPWALGACTFVHLLPK 283 Query: 240 FSATTFWPDMKKYNATWYTAVPTIHQIILDRHASHPETEYPKLRFIRSCSASLAPVILSR 299 F + Y P +++++L + S ++P L+ + SL P L Sbjct: 284 FDPLVILKTLSSYPIKSMMGAPIVYRMLLQQDLS--SYKFPHLQNCVTVGESLLPETLEN 341 Query: 300 LEEAFGAPVLEAYAMTE-ATHLMSSNPLPEEGPHKPGSVGKPVG-QEMAILNEKGEIQEP 357 G + E+Y TE M S + KPG +G ++ I+++KG + P Sbjct: 342 WRAQTGLDIRESYGQTETGLTCMVSKTMK----IKPGYMGTAASCYDVQIIDDKGNVLPP 397 Query: 358 NNKGEVCIRGP-----NVTKGYKNNPEANKAGFEFGWFHTGDIGYFDTDGYLHLVGRIKE 412 +G++ IR + GY +NP+ A ++ GD G D DGY +GR + Sbjct: 398 GTEGDIGIRVKPIRPIGIFSGYVDNPDKTAANIRGDFWLLGDRGIKDEDGYFQFMGRADD 457 Query: 413 LINRGGEKISPIEVDAVLLTHPDVSQGVAFGVPDEKYGEEINCAVI---------PREGT 463 +IN G +I P EV+ L+ HP V + PD GE + V+ P + T Sbjct: 458 IINSSGYRIGPSEVENALMEHPAVVETAVISSPDPVRGEVVKAFVVLASQFLSHDPEQLT 517 Query: 464 TVTEEDIKAFCKKNLAAFKVPKRVFITDNLPKTASGKIQR 503 ++ +K+ A +K P+++ NLPKT +GKIQR Sbjct: 518 KELQQHVKSVT----APYKYPRKIEFVLNLPKTVTGKIQR 553 >5JRH-A nrPDB Length = 660 Score = 133 bits (335), Expect = 1e-31, Method: Compositional matrix adjust. Identities = 136/520 (26%), Positives = 221/520 (42%), Gaps = 54/520 (10%) Query: 30 NLTHARLHDLIERAASRLVSDAGIKPGDVVALTFPNTVEFVIMFLAVIRARATAAPLNAA 89 ++++ LH + R A+ L+ D GIK GDVVA+ P E + LA R A + + Sbjct: 107 HISYRELHRDVCRFANTLL-DLGIKKGDVVAIYMPMVPEAAVAMLACARIGAVHSVIFGG 165 Query: 90 YTAEEFEFYLSDSDSKLLLTSKEGNAPAQEAASK------LKISHVTAT-----LLDAGS 138 ++ E + DS S+L++T+ EG + K LK +VT+ L GS Sbjct: 166 FSPEAVAGRIIDSSSRLVITADEGVRAGRSIPLKKNVDDALKNPNVTSVEHVIVLKRTGS 225 Query: 139 DLVLSVADS---DSVVDSAT-----ELVNHPDDGALFLHTSGTTSRPKGVPLTQLN-LAS 189 D+ +++ A+ E +N +D L+TSG+T +PKGV T L Sbjct: 226 DIDWQEGRDLWWRDLIEKASPEHQPEAMN-AEDPLFILYTSGSTGKPKGVLHTTGGYLVY 284 Query: 190 SVKNIKAVYKLTESDSTVIVLPLFHVHGLLAGLLSSLGAGAAVTLPAAGRFSATTFWP-- 247 + K V+ D + V G L L GA + F WP Sbjct: 285 AATTFKYVFDYHPGDIYWCTADVGWVTGHSYLLYGPLACGATTLM-----FEGVPNWPTP 339 Query: 248 -------DMKKYNATWYTAVPTIHQIILDRHASHPETEYPKLRFIRSCSASLAPVILSRL 300 D + N YTA I ++ + + T+ LR + S + P Sbjct: 340 ARMCQVVDKHQVNIL-YTAPTAIRALMAEGDKAIEGTDRSSLRILGSVGEPINPEAWEWY 398 Query: 301 EEAFG---APVLEAYAMTEATHLMSSNPLPEEGPHKPGSVGKPV-GQEMAILNEKGEIQE 356 + G PV++ + TE M + PLP K GS +P G + A+++ +G QE Sbjct: 399 WKKIGKEKCPVVDTWWQTETGGFMIT-PLPGAIELKAGSATRPFFGVQPALVDNEGHPQE 457 Query: 357 PNNKGEVCIRGPNVTKGYKNNPEANKAGFEFGWFHT-------GDIGYFDTDGYLHLVGR 409 +G + I + G + FE +F T GD D DGY + GR Sbjct: 458 GATEGNLVIT--DSWPGQARTLFGDHERFEQTYFSTFKNMYFSGDGARRDEDGYYWITGR 515 Query: 410 IKELINRGGEKISPIEVDAVLLTHPDVSQGVAFGVPDEKYGEEINCAVIPREGTTVTEE- 468 + +++N G ++ E+++ L+ HP +++ G+P G+ I V G + E Sbjct: 516 VDDVLNVSGHRLGTAEIESALVAHPKIAEAAVVGIPHAIKGQAIYAYVTLNHGEEPSPEL 575 Query: 469 --DIKAFCKKNLAAFKVPKRVFITDNLPKTASGKIQRRIV 506 +++ + +K + P + TD+LPKT SGKI RRI+ Sbjct: 576 YAEVRNWVRKEIGPLATPDVLHWTDSLPKTRSGKIMRRIL 615 >1RY2-A nrPDB Length = 663 Score = 133 bits (335), Expect = 2e-31, Method: Compositional matrix adjust. Identities = 131/548 (23%), Positives = 246/548 (44%), Gaps = 59/548 (10%) Query: 14 AKKFPDRRALSVSGK-----FNLTHARLHDLIERAASRLVSDAGIKPGDVVALTFPNTVE 68 A K P+++A+ G +++T+ L + + + A L G++ GD VA+ P E Sbjct: 92 ALKTPNKKAIIFEGDEPGQGYSITYKELLEEVCQVAQVLTYSMGVRKGDTVAVYMPMVPE 151 Query: 69 FVIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSKEGNAPAQEAASKLKISH 128 +I LA+ R A + + A +++ ++D DSK+++T+ E N + +K + Sbjct: 152 AIITLLAISRIGAIHSVVFAGFSSNSLRDRINDGDSKVVITTDESNRGGKVIETKRIVDD 211 Query: 129 VTATLLDAGSDLVLSVADSDSV-------VDSATELVNH----------PDDGALFLHTS 171 LV ++ SV +D ATE + +D L+TS Sbjct: 212 ALRETPGVRHVLVYRKTNNPSVAFHAPRDLDWATEKKKYKTYYPCTPVDSEDPLFLLYTS 271 Query: 172 GTTSRPKGVP-LTQLNLASSVKNIKAVYKLTESDSTVIVLPLFHVHGLLAGLLSSLGAGA 230 G+T PKGV T L ++ ++ + + D + + G + L G Sbjct: 272 GSTGAPKGVQHSTAGYLLGALLTMRYTFDTHQEDVFFTAGDIGWITGHTYVVYGPLLYGC 331 Query: 231 AVTL----PAAGRFSATTFWPDMKKYNATWYTAVPTIHQIILDRHASHPETEYPK-LRFI 285 A + PA +S +W + ++ T + PT +++ S+ E K LR + Sbjct: 332 ATLVFEGTPAYPNYS--RYWDIIDEHKVTQFYVAPTALRLLKRAGDSYIENHSLKSLRCL 389 Query: 286 RSCSASLAPVILSRLEEAFGA---PVLEAYAMTEA-THLMSSNPLPEEG---PHKPGSVG 338 S +A + E G P+++ Y TE+ +HL++ P G P KPGS Sbjct: 390 GSVGEPIAAEVWEWYSEKIGKNEIPIVDTYWQTESGSHLVT----PLAGGVTPMKPGSAS 445 Query: 339 KPV-GQEMAIL--NEKGEIQEPNNKGEVCIRG--PNVTKGYKNNPEANKAGF---EFGWF 390 P G + +L N E+ + +G + ++ P+ + N + + G++ Sbjct: 446 FPFFGIDAVVLDPNTGEELNTSHAEGVLAVKAAWPSFARTIWKNHDRYLDTYLNPYPGYY 505 Query: 391 HTGDIGYFDTDGYLHLVGRIKELINRGGEKISPIEVDAVLLTHPDVSQGVAFGVPDEKYG 450 TGD D DGY+ ++GR+ +++N G ++S E++A ++ P V++ G D+ G Sbjct: 506 FTGDGAAKDKDGYIWILGRVDDVVNVSGHRLSTAEIEAAIIEDPIVAECAVVGFNDDLTG 565 Query: 451 EEINCAVIPRE---GTTVTEEDIKAF-------CKKNLAAFKVPKRVFITDNLPKTASGK 500 + + V+ + +T T+++++ +K++ F PK + + D+LPKT SGK Sbjct: 566 QAVAAFVVLKNKSSWSTATDDELQDIKKHLVFTVRKDIGPFAAPKLIILVDDLPKTRSGK 625 Query: 501 IQRRIVAQ 508 I RRI+ + Sbjct: 626 IMRRILRK 633 >1V25-A nrPDB Length = 541 Score = 132 bits (333), Expect = 3e-31, Method: Compositional matrix adjust. Identities = 134/531 (25%), Positives = 233/531 (43%), Gaps = 31/531 (5%) Query: 1 MDSD-TLSGLLENVAKKFPDRRALSV--SGKFN-LTHARLHDLIERAASRLVSDAGIKPG 56 MD + L LE A F + +S +G+ + T+A ++ R L + G+ G Sbjct: 14 MDEELNLWDFLERAAALFGRKEVVSRLHTGEVHRTTYAEVYQRARRLMGGLRA-LGVGVG 72 Query: 57 DVVALTFPNTVEFVIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSKEGNAP 116 D VA N + + AV A N + +E + L+ ++ K+LL Sbjct: 73 DRVATLGFNHFRHLEAYFAVPGMGAVLHTANPRLSPKEIAYILNHAEDKVLLFDPNLLPL 132 Query: 117 AQEAASKLKISHVTATLLDAGSDLVLSVADSDSVVDSATELVNHPDDGALFL-HTSGTTS 175 + +LK + + + L+ ++ + + V P+ A + +T+GTT Sbjct: 133 VEAIRGELKTVQHFVVMDEKAPEGYLAYEEA---LGEEADPVRVPERAACGMAYTTGTTG 189 Query: 176 RPKGVPLTQ--LNLASSVKNIKAVYKLTESDSTVIVLPLFHVHGLLAGLLSSLGAGAAVT 233 PKGV + L L S ++ L+E D + V+P+FHV+ ++L GA Sbjct: 190 LPKGVVYSHRALVLHSLAASLVDGTALSEKDVVLPVVPMFHVNAWCLPYAATL-VGAKQV 248 Query: 234 LPAAGRFSATTFWPDMKKYNATWYTAVPTIHQIILDRHASHPETEYPKLRFIRS--CSAS 291 LP R + T+ VPT+ + D + E+ +L+ +R S Sbjct: 249 LPGP-RLDPASLVELFDGEGVTFTAGVPTVWLALAD----YLESTGHRLKTLRRLVVGGS 303 Query: 292 LAPVILSRLEEAFGAPVLEAYAMTEATHLMSSNPLP--------EEGPHKPGSVGKPVGQ 343 AP L E G V + Y +TE + ++ N + EE G P+ Sbjct: 304 AAPRSLIARFERMGVEVRQGYGLTETSPVVVQNFVKSHLESLSEEEKLTLKAKTGLPIPL 363 Query: 344 -EMAILNEKGEIQEPNNK--GEVCIRGPNVTKGYKNNPEANKAGFE-FGWFHTGDIGYFD 399 + + +E+G + K GEV ++GP +T GY N EA ++ G+F TGDI +D Sbjct: 364 VRLRVADEEGRPVPKDGKALGEVQLKGPWITGGYYGNEEATRSALTPDGFFRTGDIAVWD 423 Query: 400 TDGYLHLVGRIKELINRGGEKISPIEVDAVLLTHPDVSQGVAFGVPDEKYGEEINCAVIP 459 +GY+ + R+K+LI GGE IS ++++ L+ HP V + +P K+ E V+P Sbjct: 424 EEGYVEIKDRLKDLIKSGGEWISSVDLENALMGHPKVKEAAVVAIPHPKWQERPLAVVVP 483 Query: 460 REGTTVTEEDIKAFCKKNLAAFKVPKRVFITDNLPKTASGKIQRRIVAQHF 510 R EE + K A +++P + +P+T++GK +R + + + Sbjct: 484 RGEKPTPEELNEHLLKAGFAKWQLPDAYVFAEEIPRTSAGKFLKRALREQY 534 >5ES6-A nrPDB Length = 685 Score = 128 bits (321), Expect = 7e-30, Method: Compositional matrix adjust. Identities = 128/516 (24%), Positives = 224/516 (43%), Gaps = 59/516 (11%) Query: 5 TLSGLLENVAKKFPDRRALSVSGKFNLTHARLHDLIERAASRLVSDAGIKPGDVVALTFP 64 T L E + PD A+ G+ +LT+ +L++ + A L G+KP D VA+ Sbjct: 204 TFHQLFEQQVEMTPDHVAVVDRGQ-SLTYKQLNERANQLAHHL-RGKGVKPDDQVAIMLD 261 Query: 65 NTVEFVIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSKEGNAPAQEAASKL 124 +++ ++ LAV++A P++ Y E + L+DS + +LLT NA +E A+ Sbjct: 262 KSLDMIVSILAVMKAGGAYVPIDPDYPGERIAYMLADSSAAILLT----NALHEEKAN-- 315 Query: 125 KISHVTATLLDAGSDLVLSVADSDSVVDSATEL--VNHPDDGALFLHTSGTTSRPKGVPL 182 G+ ++ V D DS ++ L VN PDD ++TSG+T KGV + Sbjct: 316 ------------GACDIIDVHDPDSYSENTNNLPHVNRPDDLVYVMYTSGSTGLAKGVMI 363 Query: 183 TQLNLASSVKNIKAVYKLTESDSTVIVLPLFHVHGLLAGLLSSLGAGAAVTLPAAGRFSA 242 NL + + + + +T +D +V F G + + L AGAA+ + + R Sbjct: 364 EHHNLVNFCEWYRPYFGVTPADKA-LVYSSFSFDGSALDIFTHLLAGAALHIVPSERKYD 422 Query: 243 TTFWPDMKKYNATWYTAVPTIHQIILDRHASHPETEYPKLRFIRSCSASLAPVI-----L 297 D + +PT A+ +F++ + S VI L Sbjct: 423 LDALNDYCNQEGITISYLPT--------GAAE--------QFMQMDNQSFRVVITGGDVL 466 Query: 298 SRLEEAFGAPVLEAYAMTEATHLMSSNPLPEEGPHKPGSVGKPVGQ-EMAILNEKGEIQE 356 ++E + Y TE T +++ + P+ +GKP+ + + IL+E +Q Sbjct: 467 KKIERNGTYKLYNGYGPTECTIMVTM--FEVDKPYANIPIGKPIDRTRILILDEALALQP 524 Query: 357 PNNKGEVCIRGPNVTKGYKNNPEANKAGF----EFG--WFHTGDIGYFDTDGYLHLVGRI 410 GE+ I G + +GY N PE F + G + TGD F DG + +GR+ Sbjct: 525 IGVAGELFIVGEGLGRGYLNRPELTAEKFIVHPQTGERMYRTGDRARFLPDGNIEFLGRL 584 Query: 411 KELINRGGEKISPIEVDAVLLTHPDVSQGVAFGVPDEKYGEE--INCAVIPREGTTVTEE 468 L+ G +I P E++ L+ HP + ++ G + + V P E + Sbjct: 585 DNLVKIRGYRIEPGEIEPFLMNHPLIELTTVLA-KEQADGRKYLVGYYVAPEE---IPHG 640 Query: 469 DIKAFCKKNLAAFKVPKRVFITDNLPKTASGKIQRR 504 +++ + +L + +P P TA+GK+ RR Sbjct: 641 ELREWLGNDLPDYMIPTYFVHMKAFPLTANGKVDRR 676 >5ES8-A nrPDB Length = 776 Score = 128 bits (321), Expect = 7e-30, Method: Compositional matrix adjust. Identities = 128/516 (24%), Positives = 225/516 (43%), Gaps = 59/516 (11%) Query: 5 TLSGLLENVAKKFPDRRALSVSGKFNLTHARLHDLIERAASRLVSDAGIKPGDVVALTFP 64 T L E + PD A+ G+ +LT+ +L++ + A L G+KP D VA+ Sbjct: 204 TFHQLFEQQVEMTPDHVAVVDRGQ-SLTYKQLNERANQLAHHL-RGKGVKPDDQVAIMLD 261 Query: 65 NTVEFVIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSKEGNAPAQEAASKL 124 +++ ++ LAV++A P++ Y E + L+DS + +LLT NA +E A+ Sbjct: 262 KSLDMIVSILAVMKAGGAYVPIDPDYPGERIAYMLADSSAAILLT----NALHEEKAN-- 315 Query: 125 KISHVTATLLDAGSDLVLSVADSDSVVDSATEL--VNHPDDGALFLHTSGTTSRPKGVPL 182 G+ ++ V D DS ++ L VN PDD ++TSG+T KGV + Sbjct: 316 ------------GACDIIDVHDPDSYSENTNNLPHVNRPDDLVYVMYTSGSTGLAKGVMI 363 Query: 183 TQLNLASSVKNIKAVYKLTESDSTVIVLPLFHVHGLLAGLLSSLGAGAAVTLPAAGRFSA 242 NL + + + + +T +D +V F G + + L AGAA+ + + R Sbjct: 364 EHHNLVNFCEWYRPYFGVTPADKA-LVYSSFSFDGSALDIFTHLLAGAALHIVPSERKYD 422 Query: 243 TTFWPDMKKYNATWYTAVPTIHQIILDRHASHPETEYPKLRFIRSCSASLAPVI-----L 297 D + +PT A+ +F++ + S VI L Sbjct: 423 LDALNDYCNQEGITISYLPT--------GAAE--------QFMQMDNQSFRVVITGGDVL 466 Query: 298 SRLEEAFGAPVLEAYAMTEATHLMSSNPLPEEGPHKPGSVGKPVGQ-EMAILNEKGEIQE 356 ++E + Y TE T +++ + + P+ +GKP+ + + IL+E +Q Sbjct: 467 KKIERNGTYKLYNGYGPTECTIMVTMFEV--DKPYANIPIGKPIDRTRILILDEALALQP 524 Query: 357 PNNKGEVCIRGPNVTKGYKNNPEANKAGF----EFG--WFHTGDIGYFDTDGYLHLVGRI 410 GE+ I G + +GY N PE F + G + TGD F DG + +GR+ Sbjct: 525 IGVAGELFIVGEGLGRGYLNRPELTAEKFIVHPQTGERMYRTGDRARFLPDGNIEFLGRL 584 Query: 411 KELINRGGEKISPIEVDAVLLTHPDVSQGVAFGVPDEKYGEE--INCAVIPREGTTVTEE 468 L+ G +I P E++ L+ HP + ++ G + + V P E + Sbjct: 585 DNLVKIRGYRIEPGEIEPFLMNHPLIELTTVLA-KEQADGRKYLVGYYVAPEE---IPHG 640 Query: 469 DIKAFCKKNLAAFKVPKRVFITDNLPKTASGKIQRR 504 +++ + +L + +P P TA+GK+ RR Sbjct: 641 ELREWLGNDLPDYMIPTYFVHMKAFPLTANGKVDRR 676 >5U29-A nrPDB Length = 694 Score = 118 bits (296), Expect = 5e-27, Method: Compositional matrix adjust. Identities = 130/513 (25%), Positives = 223/513 (43%), Gaps = 56/513 (10%) Query: 42 RAASRLVSDAGIKPGDVVALTFPNTVEFVIMFLAVIRARATAAPLNAAYTAEEFEFYLSD 101 R A+ L S G+K GD V++ P T + FLA R A + + A ++AE ++D Sbjct: 160 RVANVLKS-YGVKKGDAVSIYLPMTWQAAAAFLACARIGAIHSAVFAGFSAESLRDRVND 218 Query: 102 SDSKLLLTSKEGNAPAQEAASKLKISHV--------TATLLDAGSDLVLSVADSDSVVDS 153 + K+L+T+ EG + A+K + +L + V D D Sbjct: 219 CECKVLITTDEGRRGGKTIATKQIVDAALQQCPLVENVLVLRRTGNKVPMTEGRDKWWDE 278 Query: 154 ATELVNHP----------DDGALFLHTSGTTSRPKGV-PLTQLNLASSVKNIKAVYKLTE 202 E P +D L+TSG+T +PKGV T L + +K V+ Sbjct: 279 --ECAKMPAYCPCERMASEDPLFILYTSGSTGKPKGVVHSTAGYLLGTALTLKYVFDAHP 336 Query: 203 SDSTVIVLPL-------FHVHGLLAGLLSSLGAGAAVTLPAAGRFSATTFWPDMKKYNAT 255 D + + + ++G LA +++ + P R+ W + K+ AT Sbjct: 337 DDRFACMADIGWITGHSYIIYGPLANGITTAVFESTPVYPTPSRY-----WDFVDKWKAT 391 Query: 256 WYTAVPTIHQIILDRHASHPET-EYPKLRFIRSCSASLAPVILSRLEEAFG---APVLEA 311 PT +++ H + + LR + S + P + G +++ Sbjct: 392 QLYTAPTAIRLLRRMGEDHVKNHDLSSLRVLGSVGEPINPEAWHWYNDFAGKNQCAIVDT 451 Query: 312 YAMTEATHLMSSNPLPEEGPHKPGSVGKPV-GQEMAILN-EKGEIQEPNN-KGEVCIRGP 368 Y MTE T +S PLP KPGS P G ++ I++ + G++ E N+ +G + R P Sbjct: 452 YWMTE-TGSISIAPLPGAISTKPGSATFPFFGMDVDIIDPQTGQVLEGNDVEGVLVARRP 510 Query: 369 ------NVTKGYKNNPEANKAGFEFGWFHTGDIGYFDTDGYLHLVGRIKELINRGGEKIS 422 V + +K E + G+F GD D DGY+ + GR+ ++IN G ++S Sbjct: 511 WPSIARTVYRDHKRYLETYMKPYP-GYFFFGDGAARDYDGYMWIKGRVDDVINVSGHRLS 569 Query: 423 PIEVDAVLLTHPDVSQGVAFGVPDEKYGEEINCAVI--PREGTTVTEE-----DIKAFCK 475 EV++ L+ H V++ G D+ G+ + V P T+E ++ + Sbjct: 570 TAEVESALILHKGVAETAVVGCADDLTGQAVYAFVTMKPEFDLKATKEADLSKELAIQVR 629 Query: 476 KNLAAFKVPKRVFITDNLPKTASGKIQRRIVAQ 508 K + F PK++++ +LPKT SGKI RR++ + Sbjct: 630 KVIGPFAAPKKIYLVSDLPKTRSGKIMRRVLRK 662 >4LGC-A nrPDB Length = 539 Score = 117 bits (293), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 133/529 (25%), Positives = 228/529 (43%), Gaps = 71/529 (13%) Query: 10 LENVAKKFPDRRALSVSGKFN----LTHARLHDLIERAASRLVSDAGIKPGDVVALTFPN 65 LE V++ PD A+ K +T +LH + A L+ + I PG +V FPN Sbjct: 55 LEYVSECKPDSTAVICLDKEQNCSVITWHQLHVYSSQLAWYLIENE-IGPGSIVLTMFPN 113 Query: 66 TVEFVIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSKEGNAPAQEAASKLK 125 ++E +I A+ +A A P+ +Y A E S+ + + NA A ++ K Sbjct: 114 SIEHIIAVFAIWKAGACYMPM--SYKAAE-------SEIREACDTIHPNA----AFAECK 160 Query: 126 ISHVTATLLDAGSDLVLSVADSDSVVDSATELVNHPDDGALFLHTSGTTSRPKGVPLTQL 185 I + L +D + + S + L N P+ +L + GT+ + K + Sbjct: 161 IPGLKFCL---SADEIYEAMEGRSKEMPSDRLAN-PNMISL---SGGTSGKMK---FIRQ 210 Query: 186 NLAS-----SVKNIKAVYKLTESDSTVIVLPLFH-------VHGLLAG----LLSSLGAG 229 NL ++++ + + ++V PLFH +GL G L +L G Sbjct: 211 NLPCGLDDETIRSWSLMSGMGFEQRQLLVGPLFHGAPHSAAFNGLFMGNTLVLTRNLCPG 270 Query: 230 AAVTLPAAGRFSATTFWPDMKKYNATWYTAVPTIHQIILDRHASHPETEYPKLRFIRSCS 289 + + +KKY + VPT+ + E ++ L+ + Sbjct: 271 NILNM--------------IKKYKIEFIQMVPTLMNRLAKLEGVGKE-DFASLKALCHTG 315 Query: 290 ASLAPVILSRLEEAFG-APVLEAYAMTEATHLMSSNPLPEEGPHKPGSVGKPVGQ-EMAI 347 +P + + G + E Y+MTE L +E PGS+G+PVG +++I Sbjct: 316 GVCSPWLKQIWIDLLGPEKIYEMYSMTECIGLTCIRG--DEWVKHPGSIGRPVGDSKVSI 373 Query: 348 LNEKGEIQEPNNKGEVCIRGPN---VTKGYKNNPEANKAGFEFGWFHTGDIGYFDTDGYL 404 +E G+ P GE+ + P VT+ P K G G+ GDIGY D GYL Sbjct: 374 RDENGKEVAPFEIGEIYMTAPASYLVTEYINWEPLEVKEG---GFRSVGDIGYVDEQGYL 430 Query: 405 HLVGRIKELINRGGEKISPIEVDAVLLTHPDVSQGVAFGVPDEKYGEEINCAVIPREGTT 464 + R +++ GGE + EV+ LL + D+ V G+PDE G ++ AVI G Sbjct: 431 YFSDRRSDMLVSGGENVFATEVETALLRYKDILDAVVVGIPDEDLGRRLH-AVI-ETGKE 488 Query: 465 VTEEDIKAFCKKNLAAFKVPKRVFITDNLPKTASGKIQRRIVAQHFLEK 513 + E++K F +K L +K+PK ++ + +GK R+ + + + + Sbjct: 489 IPAEELKTFLRKYLTPYKIPKTFEFVRSIRRGDNGKADRKRILEDCIAR 537 >5JNF-C nrPDB Length = 587 Score = 102 bits (255), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 106/420 (25%), Positives = 181/420 (43%), Gaps = 53/420 (12%) Query: 5 TLSGLLENVAKKFPDRRALSVSGKFNLTHARLHDLIERAASRLVSDAGIKPGDVVALTFP 64 T L E + PD A+ G+ +LT+ +L++ + A L G+KP D VA+ Sbjct: 206 TFHQLFEQQVEMTPDHVAVVDRGQ-SLTYKQLNERANQLAHHL-RGKGVKPDDQVAIMLD 263 Query: 65 NTVEFVIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSKEGNAPAQEAASKL 124 +++ ++ LAV++A P++ Y E + L+DS + +LLT NA +E A+ Sbjct: 264 KSLDMIVSILAVMKAGGAYVPIDPDYPGERIAYMLADSSAAILLT----NALHEEKAN-- 317 Query: 125 KISHVTATLLDAGSDLVLSVADSDSVVDSATEL--VNHPDDGALFLHTSGTTSRPKGVPL 182 G+ ++ V D DS ++ L VN PDD ++TSG+T KGV + Sbjct: 318 ------------GACDIIDVHDPDSYSENTNNLPHVNRPDDLVYVMYTSGSTGLAKGVMI 365 Query: 183 TQLNLASSVKNIKAVYKLTESDSTVIVLPLFHVHGLLAGLLSSLGAGAAVTLPAAGRFSA 242 NL + + + + +T +D +V F G + + L AGAA+ + + R Sbjct: 366 EHHNLVNFCEWYRPYFGVTPADKA-LVYSSFSFDGSALDIFTHLLAGAALHIVPSERKYD 424 Query: 243 TTFWPDMKKYNATWYTAVPTIHQIILDRHASHPETEYPKLRFIRSCSASLAPVI-----L 297 D + +PT +F++ + S VI L Sbjct: 425 LDALNDYCNQEGITISYLPT----------------GAAEQFMQMDNQSFRVVITGGDVL 468 Query: 298 SRLEEAFGAPVLEAYAMTEATHLMSSNPLPEEGPHKPGSVGKPVGQ-EMAILNEKGEIQE 356 ++E + Y TE T +++ + P+ +GKP+ + + IL+E +Q Sbjct: 469 KKIERNGTYKLYNGYGPTECTIMVTM--FEVDKPYANIPIGKPIDRTRILILDEALALQP 526 Query: 357 PNNKGEVCIRGPNVTKGYKNNPEANKAGF----EFG--WFHTGDIGYFDTDGYLHLVGRI 410 GE+ I G + +GY N PE F + G + TGD F DG + +GR+ Sbjct: 527 IGVAGELFIVGEGLGRGYLNRPELTAEKFIVHPQTGERMYRTGDRARFLPDGNIEFLGRL 586 >3PBK-A nrPDB Length = 583 Score = 98.6 bits (244), Expect = 5e-21, Method: Compositional matrix adjust. Identities = 135/536 (25%), Positives = 206/536 (38%), Gaps = 55/536 (10%) Query: 10 LENVAKKFPDRRALSVSGKFNLTHARLHDLIERAASRLVSDAGIKPGDVVALTFPNTVEF 69 L + F DRR + L + L E A RL+S +K GD VAL + EF Sbjct: 31 LSSAGMNFYDRRC---QLEDQLEYQTLKARAEAGAKRLLS-LNLKKGDRVALIAETSSEF 86 Query: 70 VIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSKEGNAPAQEAASKLKISHV 129 V F A A A PL + DS S L PA + V Sbjct: 87 VEAFFACQYAGLVAVPLAIPMGVGQ-----RDSWSAKLQGLLASCQPAAIITGDEWLPLV 141 Query: 130 TATLLDAGSDLVLSVADSDSVVDSATELVNH-PDDGALFLHTSGTTSRPKGVPLTQLNLA 188 A D VLS A ++ ++ L P+D A +TSG+T P+GV +T + Sbjct: 142 NAATHDNPELHVLSHAWFKALPEADVALQRPVPNDIAYLQYTSGSTRFPRGVIITHREVM 201 Query: 189 SSVKNIK-AVYKLTESDSTVIVLPLFHVHGLLAGLLSSLGAGAAVTLPAAGRFSATTF-W 246 ++++ I KL D V LP +H GL+ LL+ + +V F+ W Sbjct: 202 ANLRAISHDGIKLRPGDRCVSWLPFYHDMGLVGFLLTPVATQLSVDYLRTQDFAMRPLQW 261 Query: 247 PDMKKYNATWYTAVPTIHQIILDRHASHPETEYPKLRFIRSCSASLAPV---ILSRLEEA 303 + N + P + R + + L R P+ L + E Sbjct: 262 LKLISKNRGTVSVAPPFGYELCQRRVNEKDLAELDLSCWRVAGIGAEPISAEQLHQFAEC 321 Query: 304 F------GAPVLEAYAMTEATHLMS--------------SNPLPEEGPH-KPGS------ 336 F + Y + E +S + L +G PG+ Sbjct: 322 FRQVNFDNKTFMPCYGLAENALAVSFSDEASGVVVNEVDRDILEYQGKAVAPGAETRAVS 381 Query: 337 ----VGKPVGQE-MAILNEKGEIQEPNNKGEVCIRGPNVTKGYKNNPEANKAGFEFGWFH 391 GK + + + I NE G G +CI GP++ GY + + GW Sbjct: 382 TFVNCGKALPEHGIEIRNEAGMPVAERVVGHICISGPSLMSGYFGDQVSQDEIAATGWLD 441 Query: 392 TGDIGYFDTDGYLHLVGRIKELINRGGEKISPIEVDAVLLTHPDVSQG--VAFGVPDEKY 449 TGD+GY DGYL++ GRIK+LI G I P +++ + P++ G +AF EK Sbjct: 442 TGDLGYL-LDGYLYVTGRIKDLIIIRGRNIWPQDIEYIAEQEPEIHSGDAIAFVTAQEKI 500 Query: 450 GEEINCAVIPREGTTVTEEDIKAFCKKNLAAFKVPKRVFIT--DNLPKTASGKIQR 503 +I C + E + I A + + F V + + ++P+T+SGK R Sbjct: 501 ILQIQCRISDEERRG---QLIHALAARIQSEFGVTAAIDLLPPHSIPRTSSGKPAR 553 >3E7W-A nrPDB Length = 511 Score = 96.7 bits (239), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 131/529 (24%), Positives = 223/529 (42%), Gaps = 60/529 (11%) Query: 10 LENVAKKFPDRRALSVSGKFNLTHARLHDLIERAAS---RLVSDAGIKPGDVVALTFPNT 66 ++ A+ +P A G+ +LT+ L + +RAA+ + +S P V P+ Sbjct: 7 IQTHAETYPQTDAFRSQGQ-SLTYQELWEQSDRAAAAIQKRISGEKKSPILVYGHMEPH- 64 Query: 67 VEFVIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSKEGNAPAQEAASKLKI 126 ++ FL ++A P++ + +E + S ++LL+ A+ L I Sbjct: 65 --MIVSFLGSVKAGHPYIPVDLSIPSERIAKIIESSGAELLI-----------HAAGLSI 111 Query: 127 SHVTATLLDAGSDLVL-----SVADSDSVVDSATELVNHPDDGALFLHTSGTTSRPKGVP 181 V + ++ +L SV+ V + T + ++TSG+T PKGV Sbjct: 112 DAVGQQIQTVSAEELLENEGGSVSQDQWVKEHETFYI---------IYTSGSTGNPKGVQ 162 Query: 182 LTQLNLASSVKNIKAVYKLTESDSTVIVLPL-FHVHGL-LAGLLSSLGAGAAVTLPAAGR 239 ++ NL S I A + ++ + P F + + L L S G VT A + Sbjct: 163 ISAANLQSFTDWICADFPVSGGKIFLNQAPFSFDLSVMDLYPCLQSGGTLHCVTKDAVNK 222 Query: 240 FSATTFWPDMKKYNATWYTAVPTIHQIILDRHASHPETEYPKLRFIRSCSASLAPVILSR 299 + ++KK +T+ P+ Q+ L + P C L + Sbjct: 223 --PKVLFEELKKSGLNVWTSTPSFVQMCL-MDPGFSQDLLPHADTFMFCGEVLPVSVAKA 279 Query: 300 LEEAF-GAPVLEAYAMTEATHLMSS----NPLPEEGPHKPGSVGKPVGQEMAILNEKGEI 354 L E F A + Y TEAT ++S N + P KP + I++E+G+ Sbjct: 280 LLERFPKAKIFNTYGPTEATVAVTSVEITNDVISRSESLPVGFAKP-DMNIFIMDEEGQP 338 Query: 355 QEPNNKGEVCIRGPNVTKGYKNNPEANKAGF---EFGW-FHTGDIGYFDTDGYLHLVGRI 410 KGE+ I GP+V++GY PE + F E W + TGD G F DG + GR+ Sbjct: 339 LPEGEKGEIVIAGPSVSRGYLGEPELTEKAFFSHEGQWAYRTGDAG-FIQDGQIFCQGRL 397 Query: 411 KELINRGGEKISPIEVDAVLLTHPDVSQGV--AFGVPDEKYG--EEINCAVIPREGTTVT 466 I G ++ E++ H SQ V A +P + G E + A++P E Sbjct: 398 DFQIKLHGYRMELEEIE----FHVRQSQYVRSAVVIPYQPNGTVEYLIAAIVPEEHEFEK 453 Query: 467 EEDIKAFCKKNLA----AFKVPKRVFITDNLPKTASGKIQRRIVAQHFL 511 E + + KK LA A+ +P++ D++ TA+GKI R+ + + L Sbjct: 454 EFQLTSAIKKELAASLPAYMIPRKFIYQDHIQMTANGKIDRKRIGEEVL 502 >4R0M-B nrPDB Length = 643 Score = 92.4 bits (228), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 100/381 (26%), Positives = 169/381 (44%), Gaps = 41/381 (10%) Query: 161 PDDGALFLHTSGTTSRPKGVPLTQLNLASSVKNIKAVYKLTESDSTVIVLPLFHVHGLL- 219 P D AL L TSG+T PKGV LT N+ S + T+ + T+ +PL HV ++ Sbjct: 173 PQDAALLLFTSGSTGMPKGVILTHHNILSMTAGTVVMNHFTQQEVTLNWMPLDHVGAIVF 232 Query: 220 AGLLSSLGAGAAVTLPAAGRFSATTFWPDMKKYNATWYTAVPTIHQIILDRHAS---HPE 276 G+++ A + +P W ++ + + + P ++++ A H Sbjct: 233 LGIMAVDLACDQIHVPMELVLRQPLQWLELIQKHQVSISWSPNFAFSLINQQAEELKHVS 292 Query: 277 TEYPKLRFIRSCSASLAPVILSRLEEAFGAPVLE------AYAMTEA------THLMSSN 324 ++F+ + ++ + E L+ A+ MTE+ + +S N Sbjct: 293 YNLSSMKFLVNAGEQVSVKTIRLFLEILEKHQLQERAIKPAFGMTESCSGITWSAGLSKN 352 Query: 325 PLPEEGPHKPGSVGKPV-GQEMAILNEKGEIQEPNNKGEVCIRGPNVTKGYKNNPEANKA 383 L EE S+GKP+ G + I++++ G + I+G +VTKGY NN E N+ Sbjct: 353 ELTEENSFV--SLGKPIPGATIRIVDQENNPLPEREIGRLQIQGNSVTKGYYNNNELNQE 410 Query: 384 GFEFGWFHTGDIGYFDTDGYLHLVGRIKE--LINRGGEKISPIEVDAVLLTHPDVSQGVA 441 F+ GWF TGD+GY + G L + GR K+ +IN +E L VS A Sbjct: 411 VFQEGWFTTGDLGYL-SKGELFITGREKQEIIINGVNYFAHELETTIEELEGVKVSYTAA 469 Query: 442 FGVPDEKYGEEINCAVIP--------REGTTVTEEDIKAFCKKNLA---AFKVPKRVFIT 490 F V D+ E + +I +G V + I++ + A+ +P + Sbjct: 470 FAVFDQ--SRETDLLIITFSPESEQFEQGIKVVRK-IRSHVTQKFGIAPAYVIP----LE 522 Query: 491 DNL-PKTASGKIQRRIVAQHF 510 NL PKT+ GK+Q+ + + F Sbjct: 523 RNLVPKTSIGKVQKSKLKKDF 543 >5EY8-A nrPDB Length = 630 Score = 91.3 bits (225), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 133/581 (22%), Positives = 220/581 (37%), Gaps = 118/581 (20%) Query: 30 NLTHARLHDLIERAASRLVSDAGIKPGDVVALTFPNTVEFVIMFLAVIRARATAAPL--- 86 +LT A+ A+RL +PGD VA+ P +++++ F + A A PL Sbjct: 53 DLTWAQFSARNRAVAARL--QQVTQPGDRVAILCPQNLDYLVAFFGALYAGRIAVPLFDP 110 Query: 87 NAAYTAEEFEFYLSDSDSKLLLTSKEGNAPAQEAASKLKISHVTATLLDAGSDLVLSVAD 146 + L + +LT+ E A E K + V++V Sbjct: 111 SEPGHVGRLHAVLDNCHPSAILTTTE----AAEGVRKFFRTRPANQ-----RPRVIAV-- 159 Query: 147 SDSVVDSATELVNHPDDG-----ALFLHTSGTTSRPKGVPLTQLNLASSVKNIKAVYKLT 201 D+V D +PD+ A +TSG+T P GV +T LNLA++V + + Sbjct: 160 -DAVPDDVASTWVNPDEPDETTIAYLQYTSGSTRIPTGVQITHLNLATNVVQVIEALEGE 218 Query: 202 ESDSTVIVLPLFHVHGLLAGLLSSL-GAGAAVTLPAAGRFSATTFWPDMKKYNATWYTAV 260 E D + LP FH GL+ LL+ + G PAA + ++ + + Sbjct: 219 EGDRGLSWLPFFHDMGLITALLAPMIGHYFTFMTPAAFVRRPERWIRELARKEGDTGGTI 278 Query: 261 PTIHQIILDRHASH-------PETEYPKLRFIRSCSASLAPVILSRLEEAFG------AP 307 D A+ P + ++ + + S ++ + R EAFG Sbjct: 279 SVAPNFAFDHAAARGVPKPGSPPLDLSNVKAVLNGSEPISAATVRRFNEAFGPFGFPPKA 338 Query: 308 VLEAYAMTEATHLMSSNPLPEE---------------------------GPHKPGSVGKP 340 + +Y + EAT +S+ P EE G VG Sbjct: 339 IKPSYGLAEATLFVSTTPSAEEPKIITVDRDQLNSGRIVEVDADSPKAVAQASAGKVG-- 396 Query: 341 VGQEMAILNEKGEIQEPNNK-GEVCIRGPNVTKGYKNNPEANKAGFE------------- 386 + + I++ + + P+ + GE+ I G N+ GY PE + A F+ Sbjct: 397 IAEWAVIVDAESATELPDGQVGEIWISGQNMGTGYWGKPEESVATFQNILKSRTNPSHAE 456 Query: 387 -----FGWFHTGDIGYFDTDGYLHLVGRIKELINRGGEKISPIEVDAVLLTHPDVSQGV- 440 W TGD G F DG L++ GR+K+L+ G P +++ + + S+ + Sbjct: 457 GATDDATWVRTGDYGAF-YDGDLYITGRVKDLVIIDGRNHYPQDLE---YSAQEASKAIR 512 Query: 441 -----AFGVPDEKYGEEI---NCAVIPREGTTVTEE--------------DIKAFCKKNL 478 AF VP + +E+ + I R+ +E+ DI Sbjct: 513 TGYVAAFSVPANQLPDEVFENAHSGIKRDPDDTSEQLVIVAERAPGAHKLDIGPITDDIR 572 Query: 479 AAFKVPKRVFITDNL-------PKTASGKIQRRIVAQHFLE 512 AA V V + D L P+T+SGKI RR +L+ Sbjct: 573 AAIAVRHGVTVRDVLLTAAGAIPRTSSGKIGRRACRAAYLD 613 >3FCE-A nrPDB Length = 512 Score = 89.0 bits (219), Expect = 5e-18, Method: Compositional matrix adjust. Identities = 107/460 (23%), Positives = 189/460 (41%), Gaps = 49/460 (10%) Query: 68 EFVIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSKEGNAPAQEAASKLKIS 127 E +I FL ++A P++ + A+ + +S +KLLL++ + Sbjct: 63 EMIINFLGCVKAGHAYIPVDLSIPADRVQRIAENSGAKLLLSA----------------T 106 Query: 128 HVTATLLDAGSDLVLSVADSDSVVD-SATELVNHP--------DDGALFLHTSGTTSRPK 178 VT T DL + + D++ D T N P D+ ++TSG+T PK Sbjct: 107 AVTVT------DLPVRIVSEDNLKDIFFTHKGNTPNPEHAVKGDENFYIIYTSGSTGNPK 160 Query: 179 GVPLTQLNLASSVKNIKAVYKLTESDSTVIVLPLFHVHGLLAGLLSSLGAGAAVTLPAAG 238 GV +T L S K + L + P ++ S + G + Sbjct: 161 GVQITYNCLVSFTKWAVEDFNLQTGQVFLNQAPFSFDLSVMDIYPSLVTGGTLWAIDKDM 220 Query: 239 RFSATTFWPDMKKYNATWYTAVPTIHQIILDRHASHPETEYPKLRFIRSCSASLAPVILS 298 + +++ + +T+ P+ ++ L AS E+ P ++ C L + Sbjct: 221 IARPKDLFASLEQSDIQVWTSTPSFAEMCL-MEASFSESMLPNMKTFLFCGEVLPNEVAR 279 Query: 299 RLEEAF-GAPVLEAYAMTEATHLMSSNPLPEEGPHKPGSVGKPVGQ-----EMAILNEKG 352 +L E F A ++ Y TEAT ++ + EE + S+ PVG + I+ E G Sbjct: 280 KLIERFPKATIMNTYGPTEATVAVTGIHVTEEVLDQYKSL--PVGYCKSDCRLLIMKEDG 337 Query: 353 EIQEPNNKGEVCIRGPNVTKGYKNNPEANKAGFEF----GWFHTGDIGYFDTDGYLHLVG 408 I KGE+ I GP+V+ GY +PE + F + TGD GY + +G L G Sbjct: 338 TIAPDGEKGEIVIVGPSVSVGYLGSPELTEKAFTMIDGERAYKTGDAGYVE-NGLLFYNG 396 Query: 409 RIKELINRGGEKISPIEVDAVLLTHPDVSQGVAFGVPDEKYGEEINCAVIPREGTTVTEE 468 R+ I G ++ E++ L V V + + + + V+P E + E Sbjct: 397 RLDFQIKLHGYRMELEEIEHHLRACSYVEGAVIVPIKKGEKYDYLLAVVVPGEHSFEKEF 456 Query: 469 DIKAFCKKNLAA----FKVPKRVFITDNLPKTASGKIQRR 504 + + KK L + +P++ ++P T +GK+ R+ Sbjct: 457 KLTSAIKKELNERLPNYMIPRKFMYQSSIPMTPNGKVDRK 496 >3L8C-A nrPDB Length = 521 Score = 83.2 bits (204), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 96/364 (26%), Positives = 153/364 (42%), Gaps = 31/364 (8%) Query: 162 DDGALFLHTSGTTSRPKGVPLTQLNLASSVKNI--KAVYKLTESDSTVIVLPL-FHVHGL 218 DD + TSGTT +PKGV ++ NL S + A + + + + P F + + Sbjct: 145 DDNYYIIFTSGTTGQPKGVQISHDNLLSFTNWMIEDAAFDVPKQPQMLAQPPYSFDLSVM 204 Query: 219 LAGLLSSLGAGAAVTLPAAGRFSATTFWPDMKKYNATWYTAVPTIHQIILDRHASHPETE 278 +LG G LP + + + +T+ P+ + + + + Sbjct: 205 YWAPTLALG-GTLFALPKELVADFKQLFTTIAQLPVGIWTSTPSFADMAM-LSDDFCQAK 262 Query: 279 YPKLRFIRSCSASLAPVILSRLEEAF-GAPVLEAYAMTEATHLMSSNPLPEEGPHK---- 333 P L L +L E F A ++ AY TEAT +S+ + E Sbjct: 263 MPALTHFYFDGEELTVSTARKLFERFPSAKIINAYGPTEATVALSAIEITREMVDNYTRL 322 Query: 334 PGSVGKPVGQEMAILNEKGEIQEPNNKGEVCIRGPNVTKGYKNNPEAN-KAGFEFGW--- 389 P KP I++E G+ +GE+ + GP V+KGY NNPE +A F F Sbjct: 323 PIGYPKP-DSPTYIIDEDGKELSSGEQGEIIVTGPAVSKGYLNNPEKTAEAFFTFKGQPA 381 Query: 390 FHTGDIGYFDTDGYLHLVGRIKELINRGGEKISPIEVDAVLLTHPDVSQGVAFGVPDEKY 449 +HTGDIG D L GR+ I G +I +V L P V+ VA VP +Y Sbjct: 382 YHTGDIGSLTEDNILLYGGRLDFQIKYAGYRIELEDVSQQLNQSPMVASAVA--VP--RY 437 Query: 450 GEE-----INCAVIPREGTT-------VTEEDIKAFCKKNLAAFKVPKRVFITDNLPKTA 497 +E + ++ ++G + IKA K ++ ++ +P + D+LP T Sbjct: 438 NKEHKVQNLLAYIVVKDGVKERFDRELELTKAIKASVKDHMMSYMMPSKFLYRDSLPLTP 497 Query: 498 SGKI 501 +GKI Sbjct: 498 NGKI 501 >3LNV-A nrPDB Length = 590 Score = 79.0 bits (193), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 129/544 (23%), Positives = 218/544 (40%), Gaps = 77/544 (14%) Query: 31 LTHARLHDLIERAASRLVSDAGIKPGDVVALTFPNTVEFVIMFLAVIRARATAAPLNAAY 90 +T+ +L D +A + + G KPGD V L F + + FL + A A P+ Sbjct: 41 MTYEQL-DQHAKAIAATLQAEGAKPGDRVLLLFAPGLPLIQAFLGCLYAGCIAVPIYPP- 98 Query: 91 TAEEFEFYLSDSDSKLLLTSKEGNAPAQEAASKLKISHVTATLLDAGSDLVLSVADSDSV 150 A+E L D +++ SK P I TA L+ + A + Sbjct: 99 -AQE---KLLDKAQRIVTNSK----PVIVLMIADHIKKFTADELNTNPKFLKIPAIALES 150 Query: 151 VDSATELVNHP-----DDGALFLHTSGTTSRPKGVPLTQLNLASSVKNIKAVYKLTESDS 205 ++ P +D A +TSG+T PKGV ++ NL ++ I + + +D Sbjct: 151 IELNRSSSWQPTSIKSNDIAFLQYTSGSTMHPKGVMVSHHNLLDNLNKIFTSFHM--NDE 208 Query: 206 TVIV--LPLFHVHGLLAGLLSSLGAGAAVTLPAAGRF--SATTFWPDMKKYNATWYTAVP 261 T+I LP H GL+ +L+ + G + + F + ++ + KY AT + P Sbjct: 209 TIIFSWLPPHHDMGLIGCILTPIYGGIQAIMMSPFSFLQNPLSWLKHITKYKAT-ISGSP 267 Query: 262 TIHQIILDRHASHPETEYPKLRFIRSCSASLAPVILSRLEEAFGA---------PVLEAY 312 + + E L + PV +E + A Y Sbjct: 268 NFAYDYCVKRIREEKKEGLDLSSWVTAFNGAEPVREETMEHFYQAFKEFGFRKEAFYPCY 327 Query: 313 AMTEATHLMSSNP---------LPEE---------------GPHKPGSVGKPVGQEMAIL 348 + EAT L++ L +E G +K S G P+ QE+ I+ Sbjct: 328 GLAEATLLVTGGTPGSSYKTLTLAKEQFQDHRVHFADDNSPGSYKLVSSGNPI-QEVKII 386 Query: 349 NEKGEI-QEPNNKGEVCIRGPNVTKGYKNNPEANKAGFEFG---------WFHTGDIGYF 398 + I + + GE+ ++ +V KGY N PE + F + TGD+G+ Sbjct: 387 DPDTLIPCDFDQVGEIWVQSNSVAKGYWNQPEETRHAFAGKIKDDERSAIYLRTGDLGFL 446 Query: 399 DTDGYLHLVGRIKELINRGGEKISPIEVDAVLL---THPDVSQGVAFGVPDE-KYGEEIN 454 + L++ GRIK+LI G+ P +++ L+ H + + AF + +E +Y + Sbjct: 447 H-ENELYVTGRIKDLIIIYGKNHYPQDIEFSLMHSPLHHVLGKCAAFVIQEEHEYKLTVM 505 Query: 455 CAVIPREGTTVTEE----DIKAFCKKNLAAFKVPKRVFI-TDNLPKTASGKIQRRIVAQH 509 C V R V ++ +I +N +V V I +P T SGKI+R +H Sbjct: 506 CEVKNRFMDDVAQDNLFNEIFELVYEN-HQLEVHTIVLIPLKAMPHTTSGKIRRNFCRKH 564 Query: 510 FLEK 513 L+K Sbjct: 565 LLDK 568 >5D6N-A nrPDB Length = 508 Score = 77.8 bits (190), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 102/449 (22%), Positives = 167/449 (37%), Gaps = 85/449 (18%) Query: 30 NLTHARLHDLIERAASRLVSDAGIKPGDVVALTFPNTVEFVIMFLAVIRARATAAPL--- 86 +LT A+ A+RL +PGD VA+ P +++++ F + A A PL Sbjct: 77 DLTWAQFSARNRAVAARL--QQVTQPGDRVAILCPQNLDYLVAFFGALYAGRIAVPLFDP 134 Query: 87 NAAYTAEEFEFYLSDSDSKLLLTSKEGNAPAQEAASKLKISHVTATLLDAGSDLVLSVAD 146 + L + +LT+ E A E K ++ V Sbjct: 135 SEPGHVGRLHAVLDNCHPSAILTTTE----AAEGVRKF--------FRTRPANQRPRVIA 182 Query: 147 SDSVVDSATELVNHPDDG-----ALFLHTSGTTSRPKGVPLTQLNLASSVKNIKAVYKLT 201 D+V D +PD+ A +TSG+T P GV +T LNLA++V + + Sbjct: 183 VDAVPDDVASTWVNPDEPDETTIAYLQYTSGSTRIPTGVQITHLNLATNVVQVIEALEGE 242 Query: 202 ESDSTVIVLPLFHVHGLLAGLLSSL-GAGAAVTLPAAGRFSATTFWPDMKKYNATWYTAV 260 E D + LP FH GL+ LL+ + G PAA + ++ + + Sbjct: 243 EGDRGLSWLPFFHDMGLITALLAPMIGHYFTFMTPAAFVRRPERWIRELARKEGDTGGTI 302 Query: 261 PTIHQIILDRHASH-------PETEYPKLRFIRSCSASLAPVILSRLEEAFG------AP 307 D A+ P + ++ + + S ++ + R EAFG Sbjct: 303 SVAPNFAFDHAAARGVPKPGSPPLDLSNVKAVLNGSEPISAATVRRFNEAFGPFGFPPKA 362 Query: 308 VLEAYAMTEATHLMSSNPLPEE---------------------------GPHKPGSVGKP 340 + +Y + EAT +S+ P EE G VG Sbjct: 363 IKPSYGLAEATLFVSTTPSAEEPKIITVDRDQLNSGRIVEVDADSPKAVAQASAGKVG-- 420 Query: 341 VGQEMAILNEKGEIQEPNNK-GEVCIRGPNVTKGYKNNPEANKAGFE------------- 386 + + I++ + + P+ + GE+ I G N+ GY PE + A F+ Sbjct: 421 IAEWAVIVDAESATELPDGQVGEIWISGQNMGTGYWGKPEESVATFQNILKSRTNPSHAE 480 Query: 387 -----FGWFHTGDIGYFDTDGYLHLVGRI 410 W TGD G F DG L++ GR+ Sbjct: 481 GATDDATWVRTGDYGAF-YDGDLYITGRV 508 >6NJ0-A nrPDB Length = 451 Score = 77.0 bits (188), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 92/342 (26%), Positives = 148/342 (43%), Gaps = 49/342 (14%) Query: 170 TSGTTSRPKGVPLTQLNLASSVKNIKAVYKLTESDSTVIVLPLFHVHGLLAGLL-SSLGA 228 TSG+T PK T +S + + ++ + D ++ LPLFHV G G++ L A Sbjct: 142 TSGSTGLPKAAVHTYQAHLASAQGVLSLIPFGDHDDWLLSLPLFHVSG--QGIMWRWLYA 199 Query: 229 GAAVTL----PAAGRFSATTFWPDMKKYNATWYTAVPT-IHQIILDRHASHPETEYPKLR 283 GA +T+ P + T + VPT + +++++R + L+ Sbjct: 200 GARMTVRDKQPLEQMLAGCTH-----------ASLVPTQLWRLLVNRSSV-------SLK 241 Query: 284 FIRSCSASLAPVILSRLEEAFGAPVLEAYAMTEATHLMSSNPLPEEGPHKPGSVGKPV-G 342 + A++ PV L+ G Y +TE +S +E VG P+ G Sbjct: 242 AVLLGGAAI-PVELTEQAREQGIRCFCGYGLTE----FASTVCAKEA-DGLADVGSPLPG 295 Query: 343 QEMAILNEKGEIQEPNNKGEVCIRGPNVTKGYKNNPEANKAGFEFGWFHTGDIGYFDTDG 402 +E+ I+N EV +R ++ +GY N + + GW+ T D G +G Sbjct: 296 REVKIVNN-----------EVWLRAASMAEGYWRNGQLVSLVNDEGWYATRDRGEMH-NG 343 Query: 403 YLHLVGRIKELINRGGEKISPIEVDAVLLTHPDVSQGVAFGVPDEKYGEEINCAVIPREG 462 L +VGR+ L GGE I P EV+ V+ HP V Q V D+++G AV+ + Sbjct: 344 KLTIVGRLDNLFFSGGEGIQPEEVERVIAAHPAVLQVFIVPVADKEFGHR-PVAVMEYDH 402 Query: 463 TTVTEEDIKAFCKKNLAAFKVPKRVFITDNLPKTASGKIQRR 504 +V D+ + K LA F+ P R K KI R+ Sbjct: 403 ESV---DLSEWVKDKLARFQQPVRWLTLPPELKNGGIKISRQ 441 >5HM3-A nrPDB Length = 657 Score = 75.5 bits (184), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 125/554 (22%), Positives = 208/554 (37%), Gaps = 111/554 (20%) Query: 54 KPGDVVALTFPNTVEFVIMFLAVIRARATAAPL-NAAYTAEEFEFY--LSDSDSKLLLT- 109 +PGD VA+ P ++++I F + + A PL + A + L D +LT Sbjct: 103 QPGDRVAILCPQNLDYLISFFGALYSGRIAVPLFDPAEPGHVGRLHAVLDDCAPSTILTT 162 Query: 110 --SKEGNAP---AQEAASKLKISHVTATLLDAGSDLVLSVADSDSVVDSATELVNHPDDG 164 S EG A+ A + ++ V A + + A+ ++V Sbjct: 163 TDSAEGVRKFIRARSAKERPRVIAVDAVPTEVAATWQQPEANEETV-------------- 208 Query: 165 ALFLHTSGTTSRPKGVPLTQLNLASSVKNIKAVYKLTESDSTVIVLPLFHVHGLLAGLLS 224 A +TSG+T P GV +T LNL ++V + + E D V LP FH GL+ LL+ Sbjct: 209 AYLQYTSGSTRIPSGVQITHLNLPTNVVQVLNALEGQEGDRGVSWLPFFHDMGLITVLLA 268 Query: 225 S-LGAGAAVTLPAAGRFSATTFWPDMKKY---NATWYTAVPTI---HQIILDR-HASHPE 276 S LG PAA + ++ + ++A P H + P Sbjct: 269 SVLGHSFTFMTPAAFVRRPGRWIRELARKPGETGGTFSAAPNFAFEHAAVRGVPRDDEPP 328 Query: 277 TEYPKLRFIRSCSASLAPVILSRLEEAFGAP-------VLEAYAMTEATHLMSSNPLPE- 328 + ++ I + S ++P + + EAF AP V +Y + EAT +S+ P+ E Sbjct: 329 LDLSNVKGILNGSEPVSPASMRKFFEAF-APYGLKQTAVKPSYGLAEATLFVSTTPMDEV 387 Query: 329 ---------------------EGPHKPGSV--GKPVGQEMAILNEKGEIQE-PNNK-GEV 363 + P+ V GK E A++ + E P+ + GE+ Sbjct: 388 PTVIHVDRDELNNQRFVEVAADAPNAVAQVSAGKVGVSEWAVIVDADTASELPDGQIGEI 447 Query: 364 CIRGPNVTKGYKNNPEANKAGF------------------EFGWFHTGDIGYFDTDGYLH 405 + G N+ GY E + F + W TGD G + D +L+ Sbjct: 448 WLHGNNLGTGYWGKEEESAQTFKNILKSRISESRAEGAPDDALWVRTGDYGTYFKD-HLY 506 Query: 406 LVGRIKELINRGGEKISPIEVDAVLLTHPD---VSQGVAFGVPDEKYGEEI--------- 453 + GRIK+L+ G P +++ V AF VP + + + Sbjct: 507 IAGRIKDLVIIDGRNHYPQDLECTAQESTKALRVGYAAAFSVPANQLPQTVFDDSHAGLK 566 Query: 454 --------NCAVIPREGTTVTEEDIKAFCKKNLAAFKVPKRVFITD-------NLPKTAS 498 ++ + D + AA V V + D +P+T+S Sbjct: 567 FDPEDTSEQLVIVGERAAGTHKLDHQPIVDDIRAAIAVGHGVTVRDVLLVSAGTIPRTSS 626 Query: 499 GKIQRRIVAQHFLE 512 GKI RR +L+ Sbjct: 627 GKIGRRACRAAYLD 640 >5EY9-A nrPDB Length = 629 Score = 68.6 bits (166), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 125/555 (22%), Positives = 206/555 (37%), Gaps = 113/555 (20%) Query: 54 KPGDVVALTFPNTVEFVIMFLAVIRARATAAPL-NAAYTAEEFEFY--LSDSDSKLLLT- 109 +PGD +A+ P ++++I F + + A PL + A + L D +LT Sbjct: 75 QPGDRIAILCPQNLDYLISFFGALYSGRIAVPLFDPAEPGHVGRLHAVLDDCTPSTILTT 134 Query: 110 --SKEGNAPAQEAASKLKISHVTATLLDAGSDLVLSVADSDSVVDSATELVNHPDDGALF 167 S EG + S + V A D V + S A EL A Sbjct: 135 TDSAEGVRKFIRSRSAKERPRVIAV------DAVPTEVASTWQQPEANELTT-----AYL 183 Query: 168 LHTSGTTSRPKGVPLTQLNLASSVKNIKAVYKLTESDSTVIVLPLFHVHGLLAGLLSS-L 226 +TSG+T P GV +T LNL ++V + + E D V LP FH GL+ LL+S L Sbjct: 184 QYTSGSTRVPSGVQITHLNLPTNVLQVLNALEGQEGDRGVSWLPFFHDMGLITVLLASVL 243 Query: 227 GAGAAVTLPAAGRFSATTFWPDMKKY---NATWYTAVPTIHQIILDRHAS--------HP 275 G PAA + ++ + ++A P HA+ P Sbjct: 244 GHSFTFMTPAAFVRRPGRWIRELARKPGETGGTFSAAPNFAF----EHAAMRGVPRDDEP 299 Query: 276 ETEYPKLRFIRSCSASLAPVILSRLEEAF------GAPVLEAYAMTEATHLMSSNPLPE- 328 + ++ I + S ++P + + +AF V +Y + EAT +S+ P+ E Sbjct: 300 PLDLSNVKGILNGSEPVSPASMRKFFKAFEPYGLRETAVKPSYGLAEATLFVSTTPMDEV 359 Query: 329 ---------------------EGPHKPGSV--GKPVGQEMAILNEKGEIQE-PNNK-GEV 363 + P+ V GK E A++ + E P+ + GE+ Sbjct: 360 PTVIHVDRDELNKQRFVEVAADAPNAVAQVSAGKVGVDEWAVIVDTETASELPDGQIGEI 419 Query: 364 CIRGPNVTKGYKNNPEANKAGF------------------EFGWFHTGDIG-YFDTDGYL 404 + G N+ GY E + F + W TGD G YF G+L Sbjct: 420 WLHGNNLGIGYWGKEEESAQTFRNILKSRVPESHAEGAPDDGLWVRTGDYGTYF--KGHL 477 Query: 405 HLVGRIKELINRGGEKISPIEVDAVLLTHPD---VSQGVAFGVPDEKYGEEI-------- 453 ++ GRIK+L+ G P +++ V AF VP + +++ Sbjct: 478 YIAGRIKDLVIIDGRNHYPQDLEYTAQESTKALRVGYVAAFSVPANQLPQKVFDDPHAGL 537 Query: 454 ---------NCAVIPREGTTVTEEDIKAFCKKNLAAFKVPKRVFITD-------NLPKTA 497 ++ + + + AA V V + D +P+T+ Sbjct: 538 SFDPEDTSEQLVIVGERAAGTHKLEYQPIADDIRAAIAVGHGVTVRDVLLVSAGTIPRTS 597 Query: 498 SGKIQRRIVAQHFLE 512 SGKI RR +++ Sbjct: 598 SGKIGRRACRTAYID 612 >5WMM-A nrPDB Length = 926 Score = 66.2 bits (160), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 93/380 (24%), Positives = 151/380 (39%), Gaps = 37/380 (9%) Query: 129 VTATLLDAGSDLVLSVADSDSVVD---SATELVNHP-------DDG----ALFLHTSGTT 174 V T A DLVL+ D V+D + +L +P D G A ++TSG+T Sbjct: 136 VEPTWPRARIDLVLADLDPALVIDERLAEEDLTGYPTRPLDTADVGGEHLAYLMYTSGST 195 Query: 175 SRPKGVPLTQLNLASSVKNIKAVYKLTESDSTVIVLPLFHVHGLLAGLLSSLGAGAAVTL 234 PKGV ++ N+ S + + + ++ P + L GAAV Sbjct: 196 GTPKGVEVSHRNVLSLA--LDPCWADADHQRVLVHAPPTFDASTYEMWVPLLHGGAAVVA 253 Query: 235 PAAGRFSATTFWPDMKKYNAT--WYTAVPTIHQIILDRHASHPETEYPKLRFIRSCSASL 292 P G+ A + + T W A + D H + ++R + + L Sbjct: 254 PP-GKLDAARLATLIAERGVTALWLPAG------LFDLITQHHPKSFVQVREVWAGGDVL 306 Query: 293 APVILSRLEEAFGA-PVLEAYAMTEATHLMSSNPLPEEGPHK-PGSVGKPV-GQEMAILN 349 +P + RL G V+ Y TE T + + K P +G+P+ G + L+ Sbjct: 307 SPAAVRRLVRDDGTLTVVNGYGPTETTTFAARYRMSAPARCKDPLPIGEPMAGSRLYALD 366 Query: 350 EKGEIQEPNNKGEVCIRGPNVTKGYKNNPEANKAGF---EFG-----WFHTGDIGYFDTD 401 ++ GE+ + G V +GY N+P F FG + TGD+ ++ D Sbjct: 367 DRLRQVPQGVIGELYVGGDGVARGYANHPPLTSERFVADPFGRPGERMYRTGDLVRWNHD 426 Query: 402 GYLHLVGRIKELINRGGEKISPIEVDAVLLTHPDVSQGVAFGVPDEKYGEEINCAVIPRE 461 G L +GR+ E + G ++ P E+ A L V+Q V D + GE A + E Sbjct: 427 GQLEFLGRVDEQVKIRGFRVEPGEIRAALRKRDGVAQAVVVPRTD-RLGERRLVAYVVPE 485 Query: 462 GTTVTEEDIKAFCKKNLAAF 481 +ED +K A + Sbjct: 486 VPAGADEDSTEHVEKWRAIY 505 >3E53-A nrPDB Length = 480 Score = 65.1 bits (157), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 95/410 (23%), Positives = 165/410 (40%), Gaps = 67/410 (16%) Query: 56 GDVVALTFPNTVEFVIMFLAVIRARATAAPLN---AAYTAEEFEFYLSDSDSKLLLTSKE 112 GD V ++ P +E+V+ FL ++A A PL+ T E + LSDS +LT+ Sbjct: 82 GDRVVISAPQGLEYVVAFLGALQAGRIAVPLSVPQGGVTDERSDSVLSDSSPVAILTTS- 140 Query: 113 GNAPAQEAASKLKISHVTATLLDAGSDLV-LSVADSDSVVDSATELVNHPDDGALFLHTS 171 +A + HV ++ ++ + + D D+ + +P A +TS Sbjct: 141 -------SAVDDVVQHVARRPGESPPSIIEVDLLDLDAPNGYTFKEDEYPST-AYLQYTS 192 Query: 172 GTTSRPKGVPLTQLNLASSVKNIKAVYKLTESD-------STVIVLPLFHVHGLLAGLLS 224 G+T P GV ++ N+ + + + + Y ++D + V LP +H GL+ G+ + Sbjct: 193 GSTRTPAGVVMSHQNVRVNFEQLMSGY-FADTDGIPPPNSALVSWLPFYHDMGLVIGICA 251 Query: 225 S-LGAGAAVTLPAAGRFSATTFWPDMKKYNATWYTAVPTIHQIILDRHASHPET---EYP 280 LG AV W + + ++A P + R + + + Sbjct: 252 PILGGYPAVLTSPVSFLQRPARWMHLMASDFHAFSAAPNFAFELAARRTTDDDMAGRDLG 311 Query: 281 KLRFIRSCSASLAPVILSRLEEAFGAPVLE------AYAMTEAT-HLMSSNP-LPEE--- 329 + I S S + + R + F L+ +Y + EAT ++ +S P P E Sbjct: 312 NILTILSGSERVQAATIKRFADRFARFNLQERVIRPSYGLAEATVYVATSKPGQPPETVD 371 Query: 330 --------GPHKPGSVGK---------PVGQEMAILNEKGEIQEPNNK-GEVCIRGPNVT 371 G KP + G P + I++ I+ P+ GE+ + G NV Sbjct: 372 FDTESLSAGHAKPCAGGGATSLISYMLPRSPIVRIVDSDTCIECPDGTVGEIWVHGDNVA 431 Query: 372 KGYKNNPEANKAGF------------EFGWFHTGDIGYFDTDGYLHLVGR 409 GY P+ ++ F E W TGD G F TDG + ++GR Sbjct: 432 NGYWQKPDESERTFGGKIVTPSPGTPEGPWLRTGDSG-FVTDGKMFIIGR 480 >4GR5-A nrPDB Length = 570 Score = 61.6 bits (148), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 47/180 (26%), Positives = 78/180 (43%), Gaps = 13/180 (7%) Query: 337 VGKPV-GQEMAILNEKGEIQEPNNKGEVCIRGPNVTKGYKNNPEANKAGF---EFG---- 388 +G P+ G+ +L++ + GE+ + G + GY + P F F Sbjct: 385 IGVPLAGKRAYVLDDDLKPAANGALGELYVAGAGLAHGYVSRPALTAERFVADPFAGPGG 444 Query: 389 --WFHTGDIGYFDTDGYLHLVGRIKELINRGGEKISPIEVDAVLLTHPDVSQGVAFGVPD 446 + TGD+ DG L VGR + + G ++ P EV+A L+ HP V Q D Sbjct: 445 ERMYRTGDLARRRADGVLEYVGRADDQVKIRGFRVEPGEVEARLVGHPAVRQAAVL-AQD 503 Query: 447 EKYGEE--INCAVIPREGTTVTEEDIKAFCKKNLAAFKVPKRVFITDNLPKTASGKIQRR 504 + G++ + V R +++ + L A+ VP D LP+T +GK+ RR Sbjct: 504 SRLGDKQLVAYVVAERADAPPDAAELRRHVAEALPAYMVPVECVPVDELPRTPNGKLDRR 563 Score = 54.7 bits (130), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 50/172 (29%), Positives = 76/172 (44%), Gaps = 19/172 (11%) Query: 9 LLENVAKKFPDRRALSVSGKFNLTHARLHDLIERAASRLVSDAGIKPGDVVALTFPNTVE 68 L E A + PD AL + LT+ L++ R A RLV G+ PG +V + + Sbjct: 80 LFEAQAARAPDAVAL-LHEADELTYGALNERANRLAHRLVG-LGVAPGTLVGVHLERGFD 137 Query: 69 FVIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSKEGNAPAQEAASKLKISH 128 V+ LAV++A L+ + E L D+ + LL+TS+ Sbjct: 138 MVVALLAVLKAGGGYTMLDPQFPVERLALSLEDTGAPLLVTSRP---------------- 181 Query: 129 VTATLLDAGSDLVLSVADSDSVVDSATELVNHPDDGALFLHTSGTTSRPKGV 180 ++ L + V A SD+ + V P+D A + TSG+T RPKGV Sbjct: 182 LSGRLTGTTTLYVEDEAASDAPAGNLATGVG-PEDVACVMFTSGSTGRPKGV 232 >4GR4-A nrPDB Length = 469 Score = 55.1 bits (131), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 50/172 (29%), Positives = 76/172 (44%), Gaps = 19/172 (11%) Query: 9 LLENVAKKFPDRRALSVSGKFNLTHARLHDLIERAASRLVSDAGIKPGDVVALTFPNTVE 68 L E A + PD AL + LT+ L++ R A RLV G+ PG +V + + Sbjct: 80 LFEAQAARAPDAVAL-LHEADELTYGALNERANRLAHRLVG-LGVAPGTLVGVHLERGFD 137 Query: 69 FVIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSKEGNAPAQEAASKLKISH 128 V+ LAV++A L+ + E L D+ + LL+TS+ Sbjct: 138 MVVALLAVLKAGGGYTMLDPQFPVERLALSLEDTGAPLLVTSRP---------------- 181 Query: 129 VTATLLDAGSDLVLSVADSDSVVDSATELVNHPDDGALFLHTSGTTSRPKGV 180 ++ L + V A SD+ + V P+D A + TSG+T RPKGV Sbjct: 182 LSGRLTGTTTLYVEDEAASDAPAGNLATGVG-PEDVACVMFTSGSTGRPKGV 232 >4WD1-A nrPDB Length = 658 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 79/385 (20%), Positives = 154/385 (40%), Gaps = 42/385 (10%) Query: 142 LSVADSDSVVDSATELVNHPDDGALFLHTSGTTSRPKGVPLTQLN-LASSVKNIKAVYKL 200 L+ AD++ V + +HP L++SGTT PK + +Q L +K + L Sbjct: 249 LTAADAEPVYEQVP--FDHP---LWVLYSSGTTGLPKAIVQSQGGILVEHLKQLGLHCDL 303 Query: 201 TESD------STVIVLPLFHVHGLLAGLLSSLGAGAAVTLPAAGRFSAT-TFWPDMKKYN 253 D ST ++ F V GLL G L G+ F AT W ++ Sbjct: 304 GPGDRFFWYTSTGWMMWNFLVSGLLTGTTIVLYDGSP-------GFPATDAQWRIAERTG 356 Query: 254 ATWYTAVPTIHQIILDRHASHP--ETEYPKLRFIRSCSASLAPVILSRLEEAFGAPVLEA 311 AT + + + + HP + + ++ + + + L P L + F A + Sbjct: 357 ATLF-GTSAAYVMACRKAGVHPARDLDLSAIQCVATTGSPLPPDGFRWLHDEFAAGGADL 415 Query: 312 YAMTEATHLMSSNPLPEEGPHKPGSVGK----PVGQEMAILNEKGEIQEPNNKGEVCIRG 367 + + + + P P +G+ +G ++ + G+ + GE+ + Sbjct: 416 WIASVSGGTDVCSCFAGAVPTLPVHIGELQAPGLGTDLQSWDPSGDPLT-DEVGELVVTN 474 Query: 368 P--NVTKGYKNNPEANKAGFEF-----GWFHTGDIGYFDTDGYLHLVGRIKELINRGGEK 420 P ++ + N+P+ ++ + G + GD + G + + GR +NR G + Sbjct: 475 PMPSMPIRFWNDPDGSRYHDSYFDTYPGVWRHGDWITLTSRGSVVIHGRSDSTLNRQGVR 534 Query: 421 ISPIEVDAVLLTHPDVSQGVAFGV--PDEKYGEEINCAVIPREGTTVTE---EDIKAFCK 475 + ++ + P++ + + G+ PD Y + + P G T+ + + IK + Sbjct: 535 MGSADIYEAVERLPEIRESLVIGIEQPDGGYWMPLFVHLAP--GATLDDALLDRIKRTIR 592 Query: 476 KNLAAFKVPKRVFITDNLPKTASGK 500 NL+ VP V +P T +GK Sbjct: 593 VNLSPRHVPDEVIEVPGIPHTLTGK 617 >3NT2-A nrPDB Length = 344 Score = 33.1 bits (74), Expect = 0.32, Method: Compositional matrix adjust. Identities = 33/121 (27%), Positives = 53/121 (43%), Gaps = 25/121 (20%) Query: 411 KELINRGGEKISPIEVDAVLLTHPDVSQGVAFGVPDEKYGEEINCAVIPREGTTVTEEDI 470 KE INR K+S E+ AV + + +Q V E+Y ++N V P + + + +E++ Sbjct: 15 KEHINRITNKLSGAEIVAVTDVNQEAAQKVV-----EQY--QLNATVYPNDDSLLADENV 67 Query: 471 KAFCKKN---------LAAFKVPKRVFITDNLPKTASG---------KIQRRIVAQHFLE 512 A + L A K K VF L TA G K+ +R+V F+ Sbjct: 68 DAVLVTSWGPAHESSVLKAIKAQKYVFCEKPLATTAEGCMRIVEEEIKVGKRLVQVGFMR 127 Query: 513 K 513 + Sbjct: 128 R 128 >4F7G-B nrPDB Length = 216 Score = 30.0 bits (66), Expect = 2.2, Method: Compositional matrix adjust. Identities = 22/74 (29%), Positives = 39/74 (52%), Gaps = 8/74 (10%) Query: 99 LSDSDSKLLLTSKE-GNAPAQEAASKLKISHVTATLLDAGSDLVLSVADSDS-------V 150 L++S +LL T+KE G P Q A ++ + + +A DL ++ ++ S + Sbjct: 137 LAESALQLLYTAKEAGGNPKQAAHTQEALEEAVQMMTEAVEDLTTTLNEAASAAGVVGGM 196 Query: 151 VDSATELVNHPDDG 164 VDS T+ +N D+G Sbjct: 197 VDSITQAINQLDEG 210 >1LMI-A nrPDB Length = 131 Score = 29.3 bits (64), Expect = 4.7, Method: Composition-based stats. Identities = 19/79 (24%), Positives = 37/79 (46%), Gaps = 2/79 (2%) Query: 183 TQLNLASSVKNIKAVYKLTESDSTVIVLPLFHVHGLLAGLLSSLGAGAAVTLPAAGRFSA 242 ++L + +V + +K+++ S+ V+P + V G + +++ A PA +F+A Sbjct: 11 SELTMTDTVGQVVLGWKVSDLKSSTAVIPGYPVAGQVWEATATVNAIRGSVTPAVSQFNA 70 Query: 243 TTFWPDMKKYNATWYTAVP 261 T D Y W A P Sbjct: 71 RT--ADGINYRVLWQAAGP 87 >3FEW-X nrPDB Length = 505 Score = 28.9 bits (63), Expect = 5.5, Method: Compositional matrix adjust. Identities = 34/120 (28%), Positives = 55/120 (45%), Gaps = 13/120 (10%) Query: 11 ENVAKKFPDRRALSVSGKFNLTHARLHDLIERAASRLVSDAGIKPGDVVALTFPN----T 66 +N AKK A V F++ R+ + A+ ++SD G K GD + + + Sbjct: 281 QNQAKK----AAYDVFYSFSMNRDRIQSDVLNKAAEVISDIGNKVGDYLGDAYKSLAREI 336 Query: 67 VEFVIMFLA-VIRARATA-APLNAAYTAEEFEFYLSDSDSKLLLTSKEGNAPAQEAASKL 124 + V F IR+ A A LN + F+F +DSD+ L + + AQ+ A+KL Sbjct: 337 ADDVKNFQGKTIRSYDDAMASLNKVLSNPGFKFNRADSDA---LANVWRSIDAQDMANKL 393 >6EDI-A nrPDB Length = 412 Score = 28.1 bits (61), Expect = 8.4, Method: Compositional matrix adjust. Identities = 18/46 (39%), Positives = 23/46 (50%), Gaps = 4/46 (8%) Query: 159 NHPDDGALFLH--TSGTTSRPKGVPLTQLNLASSVKNIKAVYKLTE 202 N PD GA FL SG S P P+T LA N+K + +L + Sbjct: 98 NLPDHGASFLRRVASGAVSVPG--PVTNGQLAGPFNNLKGIARLVD 141 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 5IE2-A nrPDB 619 e-178 5BSW-A nrPDB 439 e-123 3R44-A nrPDB 439 e-123 4WV3-A nrPDB 437 e-123 4M46-A nrPDB 430 e-121 5BUS-A nrPDB 428 e-120 3A9U-A nrPDB 427 e-120 4EAT-A nrPDB 422 e-118 3ETC-A nrPDB 422 e-118 3IVR-A nrPDB 421 e-118 4FUQ-A nrPDB 419 e-117 5DWV-A nrPDB 419 e-117 1MDF-A nrPDB 419 e-117 3GPC-A nrPDB 417 e-117 5JRH-A nrPDB 411 e-115 3TSY-A nrPDB 408 e-114 1RY2-A nrPDB 405 e-113 2D1S-A nrPDB 405 e-113 2V7B-A nrPDB 405 e-113 3O84-A nrPDB 402 e-112 1V25-A nrPDB 397 e-111 5ES8-A nrPDB 392 e-109 5ES6-A nrPDB 391 e-109 3RG2-A nrPDB 387 e-108 3DLP-X nrPDB 381 e-106 3IPL-A nrPDB 379 e-105 5U29-A nrPDB 377 e-105 3FCE-A nrPDB 370 e-103 3E7W-A nrPDB 364 e-101 5EY8-A nrPDB 362 e-100 5HM3-A nrPDB 355 2e-98 4LGC-A nrPDB 355 2e-98 5EY9-A nrPDB 352 2e-97 3PBK-A nrPDB 342 2e-94 3LNV-A nrPDB 341 5e-94 4GR5-A nrPDB 331 5e-91 5JNF-C nrPDB 311 4e-85 3L8C-A nrPDB 310 9e-85 5D6N-A nrPDB 291 6e-79 5WMM-A nrPDB 289 2e-78 4R0M-B nrPDB 270 1e-72 6NJ0-A nrPDB 261 5e-70 3E53-A nrPDB 241 4e-64 4GR4-A nrPDB 237 8e-63 Sequences not found previously or not previously below threshold: 4WD1-A nrPDB 177 9e-45 4RVO-A nrPDB 111 8e-25 2Y4O-A nrPDB 89 4e-18 2Y4N-A nrPDB 81 2e-15 6HIV-BC nrPDB 79 5e-15 5YHV-A nrPDB 35 0.11 3D02-A nrPDB 32 0.74 5YLO-A nrPDB 31 1.1 5YCL-B nrPDB 31 1.5 2EG4-A nrPDB 31 1.5 3IP1-A nrPDB 31 1.6 3ZQ4-A nrPDB 30 2.9 5NPY-A nrPDB 29 4.5 2OGE-A nrPDB 29 4.7 4KI3-A nrPDB 29 4.8 2I2W-A nrPDB 29 7.4 5B6A-A nrPDB 28 9.1 >5IE2-A nrPDB Length = 514 Score = 619 bits (1597), Expect = e-178, Method: Composition-based stats. Identities = 514/514 (100%), Positives = 514/514 (100%) Query: 1 MDSDTLSGLLENVAKKFPDRRALSVSGKFNLTHARLHDLIERAASRLVSDAGIKPGDVVA 60 MDSDTLSGLLENVAKKFPDRRALSVSGKFNLTHARLHDLIERAASRLVSDAGIKPGDVVA Sbjct: 1 MDSDTLSGLLENVAKKFPDRRALSVSGKFNLTHARLHDLIERAASRLVSDAGIKPGDVVA 60 Query: 61 LTFPNTVEFVIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSKEGNAPAQEA 120 LTFPNTVEFVIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSKEGNAPAQEA Sbjct: 61 LTFPNTVEFVIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSKEGNAPAQEA 120 Query: 121 ASKLKISHVTATLLDAGSDLVLSVADSDSVVDSATELVNHPDDGALFLHTSGTTSRPKGV 180 ASKLKISHVTATLLDAGSDLVLSVADSDSVVDSATELVNHPDDGALFLHTSGTTSRPKGV Sbjct: 121 ASKLKISHVTATLLDAGSDLVLSVADSDSVVDSATELVNHPDDGALFLHTSGTTSRPKGV 180 Query: 181 PLTQLNLASSVKNIKAVYKLTESDSTVIVLPLFHVHGLLAGLLSSLGAGAAVTLPAAGRF 240 PLTQLNLASSVKNIKAVYKLTESDSTVIVLPLFHVHGLLAGLLSSLGAGAAVTLPAAGRF Sbjct: 181 PLTQLNLASSVKNIKAVYKLTESDSTVIVLPLFHVHGLLAGLLSSLGAGAAVTLPAAGRF 240 Query: 241 SATTFWPDMKKYNATWYTAVPTIHQIILDRHASHPETEYPKLRFIRSCSASLAPVILSRL 300 SATTFWPDMKKYNATWYTAVPTIHQIILDRHASHPETEYPKLRFIRSCSASLAPVILSRL Sbjct: 241 SATTFWPDMKKYNATWYTAVPTIHQIILDRHASHPETEYPKLRFIRSCSASLAPVILSRL 300 Query: 301 EEAFGAPVLEAYAMTEATHLMSSNPLPEEGPHKPGSVGKPVGQEMAILNEKGEIQEPNNK 360 EEAFGAPVLEAYAMTEATHLMSSNPLPEEGPHKPGSVGKPVGQEMAILNEKGEIQEPNNK Sbjct: 301 EEAFGAPVLEAYAMTEATHLMSSNPLPEEGPHKPGSVGKPVGQEMAILNEKGEIQEPNNK 360 Query: 361 GEVCIRGPNVTKGYKNNPEANKAGFEFGWFHTGDIGYFDTDGYLHLVGRIKELINRGGEK 420 GEVCIRGPNVTKGYKNNPEANKAGFEFGWFHTGDIGYFDTDGYLHLVGRIKELINRGGEK Sbjct: 361 GEVCIRGPNVTKGYKNNPEANKAGFEFGWFHTGDIGYFDTDGYLHLVGRIKELINRGGEK 420 Query: 421 ISPIEVDAVLLTHPDVSQGVAFGVPDEKYGEEINCAVIPREGTTVTEEDIKAFCKKNLAA 480 ISPIEVDAVLLTHPDVSQGVAFGVPDEKYGEEINCAVIPREGTTVTEEDIKAFCKKNLAA Sbjct: 421 ISPIEVDAVLLTHPDVSQGVAFGVPDEKYGEEINCAVIPREGTTVTEEDIKAFCKKNLAA 480 Query: 481 FKVPKRVFITDNLPKTASGKIQRRIVAQHFLEKP 514 FKVPKRVFITDNLPKTASGKIQRRIVAQHFLEKP Sbjct: 481 FKVPKRVFITDNLPKTASGKIQRRIVAQHFLEKP 514 >5BSW-A nrPDB Length = 541 Score = 439 bits (1128), Expect = e-123, Method: Composition-based stats. Identities = 155/514 (30%), Positives = 244/514 (47%), Gaps = 17/514 (3%) Query: 7 SGLLENVAKKFPDRRALSVSGKFNLTHARLHDLIERAASRLVSDAGIKPGDVVALTFPNT 66 S EN+++ ++ + K T+A + + A+ L GI+P D + + PN+ Sbjct: 29 SYCFENISEFSSRPCLINGANKQIYTYADVELNSRKVAAGL-HKQGIQPKDTIMILLPNS 87 Query: 67 VEFVIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSKEGNAPAQEAASKLKI 126 EFV F+ A + N +T E S +K+++T ++ A + Sbjct: 88 PEFVFAFIGASYLGAISTMANPLFTPAEVVKQAKASSAKIIVTQACHVNKVKDYAFE--- 144 Query: 127 SHVTATLLDAGSDLVLSVA-DSDSVVDSATELVNHPDDGALFLHTSGTTSRPKGVPLTQL 185 + V +D+ + L + + + E+ PDD ++SGTT PKGV LT Sbjct: 145 NDVKIICIDSAPEGCLHFSVLTQANEHDIPEVEIQPDDVVALPYSSGTTGLPKGVMLTHK 204 Query: 186 NLASSVKNIKAV----YKLTESDSTVIVLPLFHVHGLLAGLLSSLGAGAAVTLPAAGRFS 241 L +SV + D + VLPLFH++ L + LL L GAA+ + +F Sbjct: 205 GLVTSVAQQVDGENPNLYIHSEDVMLCVLPLFHIYSLNSVLLCGLRVGAAILI--MQKFD 262 Query: 242 ATTFWPDMKKYNATWYTAVPTIHQIILDRHASHPETEYPKLRFIRSCSASLAPVILSRLE 301 +F +++Y T VP I I + + + +R + S +A L + + Sbjct: 263 IVSFLELIQRYKVTIGPFVPPIVLAIA-KSPMVDDYDLSSVRTVMSGAAPLGKELEDTVR 321 Query: 302 EAF-GAPVLEAYAMTEATHL-MSSNPLPEEGPHKPGSVGKPV-GQEMAILNE-KGEIQEP 357 F A + + Y MTEA L M E K G+ G V EM I++ G Sbjct: 322 AKFPNAKLGQGYGMTEAGPLAMCLAFAKEPFEIKSGACGTVVRNAEMKIVDPKTGNSLPR 381 Query: 358 NNKGEVCIRGPNVTKGYKNNPEANKAGFE-FGWFHTGDIGYFDTDGYLHLVGRIKELINR 416 N GE+CIRG + KGY N+PEA + GW +TGDIGY D D L +V R+KELI Sbjct: 382 NQSGEICIRGDQIMKGYLNDPEATARTIDKEGWLYTGDIGYIDDDDELFIVDRLKELIKY 441 Query: 417 GGEKISPIEVDAVLLTHPDVSQGVAFGVPDEKYGEEINCAVIPREGTTVTEEDIKAFCKK 476 G +++P E++A+LL HP++S + DE+ GE V+ G+T+TE+++K F K Sbjct: 442 KGFQVAPAELEALLLNHPNISDAAVVPMKDEQAGEVPVAFVVRSNGSTITEDEVKDFISK 501 Query: 477 NLAAFKVPKRVFITDNLPKTASGKIQRRIVAQHF 510 + +K KRVF D +PK+ SGKI R+ + Sbjct: 502 QVIFYKRIKRVFFVDAIPKSPSGKILRKDLRAKL 535 >3R44-A nrPDB Length = 517 Score = 439 bits (1128), Expect = e-123, Method: Composition-based stats. Identities = 154/511 (30%), Positives = 256/511 (50%), Gaps = 15/511 (2%) Query: 4 DTLSGLLENVAKKFPDRRA-LSVSGKFNLTHARLHDLIERAASRLVSDAGIKPGDVVALT 62 + +L A P +A + S +T+A+++ L R A L + GI GD VAL Sbjct: 16 KNIGWMLRQRATVSPRLQAYVEPSTDVRMTYAQMNALANRCADVLTA-LGIAKGDRVALL 74 Query: 63 FPNTVEFVIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSKEGNAPAQEAAS 122 PN+VEF +F + A A P+N A E F LSDS SK+++ + Sbjct: 75 MPNSVEFCCLFYGAAKLGAVAVPINTRLAAPEVSFILSDSGSKVVIYGAPSAPVIDAIRA 134 Query: 123 KLKISHVTATLLDAGSDLVLSVADSDSVVDSATELVNHPDDGALFLHTSGTTSRPKGVPL 182 + + G+D + S + + A E DD ++TSGTT PKGV Sbjct: 135 QADPPGTVTDWI--GADSLAERLRSAAADEPAVECGG--DDNLFIMYTSGTTGHPKGVVH 190 Query: 183 TQLNLASSVKNIKAVYKLTESDSTVIVLPLFHVHGLLAGLLSSLGAGAAVTLPAAGRFSA 242 T ++ S+ + + + D ++ LP+FHV L + S++ VTL + +F A Sbjct: 191 THESVHSAASSWASTIDVRYRDRLLLPLPMFHVAALTTVIFSAMRG---VTLISMPQFDA 247 Query: 243 TTFWPDMKKYNATWYTAVPTIHQIILDRHASHPETEYPKLRFIRSCSASLAPVILSRLEE 302 T W + + AVP I + + E + P R+ + A + P L ++ Sbjct: 248 TKVWSLIVEERVCIGGAVPAILNF-MRQVPEFAELDAPDFRYFITGGAPM-PEALIKIYA 305 Query: 303 AFGAPVLEAYAMTEATHLMSSNPLPEEGPHKPGSVGKP-VGQEMAILNEKGEIQEPNNKG 361 A V++ YA+TE+ + L E+ K GS G+ + ++A+ + G I+E + +G Sbjct: 306 AKNIEVVQGYALTESCGGGTLL-LSEDALRKAGSAGRATMFTDVAVRGDDGVIRE-HGEG 363 Query: 362 EVCIRGPNVTKGYKNNPEANKAGFEFGWFHTGDIGYFDTDGYLHLVGRIKELINRGGEKI 421 EV I+ + K Y N PEA + F+ GWF TGDIG D +GYL++ R+K++I GGE + Sbjct: 364 EVVIKSDILLKEYWNRPEATRDAFDNGWFRTGDIGEIDDEGYLYIKDRLKDMIISGGENV 423 Query: 422 SPIEVDAVLLTHPDVSQGVAFGVPDEKYGEEINCAVIPREGTTVTEEDIKAFCKKNLAAF 481 P E+++V++ P VS+ G+PDEK+GE I A++ + V+E+ I +C LA + Sbjct: 424 YPAEIESVIIGVPGVSEVAVIGLPDEKWGE-IAAAIVVADQNEVSEQQIVEYCGTRLARY 482 Query: 482 KVPKRVFITDNLPKTASGKIQRRIVAQHFLE 512 K+PK+V + +P+ +GKI + ++ + + Sbjct: 483 KLPKKVIFAEAIPRNPTGKILKTVLREQYSA 513 >4WV3-A nrPDB Length = 529 Score = 437 bits (1124), Expect = e-123, Method: Composition-based stats. Identities = 127/508 (25%), Positives = 221/508 (43%), Gaps = 12/508 (2%) Query: 8 GLLENVAKKFPDRRALSVSGKFNLTHARLHDLIERAASRLVSDAGIKPGDVVALTFPNTV 67 +LE ++ AL + +T ++ + + + L G++ G+ V L ++ Sbjct: 14 DILERNLPVRANKTALFTPDRE-MTFRQVSNEANQVGNAL-KGLGVRFGECVGLLTLDSA 71 Query: 68 EFVIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSKEGNAPAQEAASKLKIS 127 E+V F +++ A A +N E+E+ L D +++L+ +E + L + Sbjct: 72 EWVTSFFGIVKLGAIAVGINTLLKPPEYEYILRDCRARVLIVHQEFLPLIESIRGNLPML 131 Query: 128 HVTATLLDAGSDLVLSVADSDSVVDSATELV-NHPDDGALFLHTSGTTSRPKGVPLTQLN 186 + + + LS D + E +H +D ++SGTT PKG+P + Sbjct: 132 EHIVVIGEGPQEGYLSFNDWIRPQPTTLEAAQSHREDICSLNYSSGTTGGPKGIPHAHKD 191 Query: 187 LASSVK-NIKAVYKLTESDSTVIVLPLFHVHGLLAGLLSSLGAGAAVTLPAAGRFSATTF 245 + + V L ESD T + LF G L+ GA+ L A+ Sbjct: 192 YPLTAQLWGVNVLGLRESDRTFALAKLFFTFGTGGNLIFPWYVGASCVLFPGAARVASNV 251 Query: 246 WPDMKKYNATWYTAVPTIHQIILDRHASHPETEYPKLRFIRSCSASLAPVILSRLEEAFG 305 + ++ T + PT + L + + LR S S +L + +EA G Sbjct: 252 LSTISRFKPTIFYNAPTGYAAALAL-KDFSQHDLSSLRLCVSASEALPAALWYAWKEATG 310 Query: 306 APVLEAYAMTEATHLMSSNPLPEEGPHKPGSVGKPV-GQEMAILNEKGEIQEPNNKGEVC 364 +++ TE H+ SN G +PGS GKPV G E+ +++++G+ G V Sbjct: 311 VDIIDGIGCTENFHIFISN---RPGDIRPGSSGKPVEGYELKLVDDEGKTVPAGEIGNVL 367 Query: 365 IRGPNVTKGYKNNPEANKAGFEFGWFHTGDIGYFDTDGYLHLVGRIKELINRGGEKISPI 424 +R Y +N E ++ F+ W TGD + D DGY GR +++ GG +SP+ Sbjct: 368 LRSETAALSYWHNFEKSRQTFQGEWLATGDKYFVDADGYYWHAGRSDDMLKVGGIWVSPV 427 Query: 425 EVDAVLLTHPDVSQGVAFGVPDEKYGEEINCAVIPREGTTVTEE---DIKAFCKKNLAAF 481 EV++ L+ HP V + G PD+ + +I + +E I C + +AA+ Sbjct: 428 EVESTLIQHPAVQECAVIGCPDQSRLIKPKAFIILKPEQIPSEALIRQITDHCTEKMAAY 487 Query: 482 KVPKRVFITDNLPKTASGKIQRRIVAQH 509 K P+ + LPKTA+GKIQR + Sbjct: 488 KRPRWIEFVTELPKTATGKIQRFKLRSA 515 >4M46-A nrPDB Length = 581 Score = 430 bits (1105), Expect = e-121, Method: Composition-based stats. Identities = 138/524 (26%), Positives = 228/524 (43%), Gaps = 29/524 (5%) Query: 4 DTLSGLLENVAKKFPDRRALSV-SGKFNLTHARLHDLIERAASRLVSDAGIKPGDVVALT 62 + L ++ A+ P A + + N+T++ ++ R A + G+ +A+ Sbjct: 58 EQLHKAMKRYAQV-PGTIAFTDAHAEVNITYSEYFEMACRLAETM-KRYGLGLQHHIAVC 115 Query: 63 FPNTVEFVIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSKEGNAPAQEAAS 122 N+++F + + AP N Y E LS S ++ SK Sbjct: 116 SENSLQFFMPVCGALFIGVGVAPTNDIYNERELYNSLSISQPTIVFCSKRALQKILGVQK 175 Query: 123 KLKISHVTATLLDAGSDLV-----LSVADSDSVV-----DSATELVNHPDDGALFLHTSG 172 KL I +LD+ D + S +S D + + AL +++SG Sbjct: 176 KLPIIQ-KIVILDSREDYMGKQSMYSFIESHLPAGFNEYDYIPDSFDRETATALIMNSSG 234 Query: 173 TTSRPKGVPLTQLNLASSVKNIKA---VYKLTESDSTVIVLPLFHVHGLLAGLLSSLGAG 229 +T PKGV LT N+ + + ++ + + V+P H G+ L L G Sbjct: 235 STGLPKGVELTHKNICVRFSHCRDPVFGNQIIPDTAILTVIPFHHGFGMFT-TLGYLTCG 293 Query: 230 AAVTLPAAGRFSATTFWPDMKKYNATWYTAVPTIHQIILDRHASHPETEYPKLRFIRSCS 289 + L RF F ++ Y VPT+ + + + L I S Sbjct: 294 FRIVL--MYRFEEELFLRSLQDYKIQSALLVPTLFSF-FAKSTLVDKYDLSNLHEIASGG 350 Query: 290 ASLAPVILSRLEEAFGAP-VLEAYAMTEATHLMSSNPLPEEGPHKPGSVGK--PVGQEMA 346 A LA + + + F P + + Y +TE T + P EG KPG+ GK P Sbjct: 351 APLAKEVGEAVAKRFKLPGIRQGYGLTETTSAIIITP---EGDDKPGACGKVVPFFSAKI 407 Query: 347 ILNEKGEIQEPNNKGEVCIRGPNVTKGYKNNPEANKAGFE-FGWFHTGDIGYFDTDGYLH 405 + + G+ N +GE+C++GP + KGY NNPEA A + GW H+GDI Y+D DG+ Sbjct: 408 VDLDTGKTLGVNQRGELCVKGPMIMKGYVNNPEATSALIDKDGWLHSGDIAYYDKDGHFF 467 Query: 406 LVGRIKELINRGGEKISPIEVDAVLLTHPDVSQGVAFGVPDEKYGEEINCAVIPREGTTV 465 +V R+K LI G ++ P E++++LL HP + G+PD GE V+ EG T+ Sbjct: 468 IVDRLKSLIKYKGYQVPPAELESILLQHPFIFDAGVAGIPDPDAGELPAAVVVLEEGKTM 527 Query: 466 TEEDIKAFCKKNLAAFK-VPKRVFITDNLPKTASGKIQRRIVAQ 508 TE+++ + + A K + V D +PK +GKI R + + Sbjct: 528 TEQEVMDYVAGQVTASKRLRGGVKFVDEVPKGLTGKIDARKIRE 571 >5BUS-A nrPDB Length = 494 Score = 428 bits (1101), Expect = e-120, Method: Composition-based stats. Identities = 154/500 (30%), Positives = 237/500 (47%), Gaps = 28/500 (5%) Query: 10 LENVAKKFPDRRALSVSGKFNLTHARLHDLIERAASRLVSDAGIKPGDVVALTFPNTVEF 69 L A+ P+R AL + +T A L +R A +L + + ++ GD A+ N E Sbjct: 11 LMQRAQLTPERIALIYEDQ-TVTFAELFAASKRMAEQLAAHS-VRKGDTAAILLQNRAEM 68 Query: 70 VIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSKEGNAPAQEAASKLKISHV 129 V A A LN + E F L DS S LLT E Sbjct: 69 VYAVHACFLLGVKAVLLNTKLSTHERLFQLEDSGSGFLLTDSSFEKKEYEH--------- 119 Query: 130 TATLLDAGSDLVLSVADSDSVVDSATELVNHPDDGALFLHTSGTTSRPKGVPLTQLNLAS 189 + D ++ A + +++ ++ D A ++TSGTT +PKGV T N Sbjct: 120 --IVQTIDVDELMKEAAEEIEIEAYMQM----DATATLMYTSGTTGKPKGVQQTFGNHYF 173 Query: 190 SVKNIKAVYKLTESDSTVIVLPLFHVHGLLAGLLSSLGAGAAVTLPAAGRFSATTFWPDM 249 S + +TE D +I LPLFH+ GL + L S+ G V L RFS + + Sbjct: 174 SAVSSALNLGITEQDRWLIALPLFHISGL-SALFKSVIYGMTVVLH--QRFSVSDVLHSI 230 Query: 250 KKYNATWYTAVPTIHQIILDRHASHPETEYPKLRFIRSCSASLAPVILSRLEEAFGAPVL 309 ++ T +AV T+ +L+ PE +R I +L E G PV Sbjct: 231 NRHEVTMISAVQTMLASLLEETNRCPE----SIRCILLGGGPAPLPLLEECREK-GFPVF 285 Query: 310 EAYAMTEATHLMSSNPLPEEGPHKPGSVGKPVGQEMAILNEKGEIQEPNNKGEVCIRGPN 369 ++Y MTE + + PE K GS GKP+ + G++ EP GE+ ++GPN Sbjct: 286 QSYGMTETCSQIVTLS-PEFSMEKLGSAGKPLFSCEIKIERDGQVCEPYEHGEIMVKGPN 344 Query: 370 VTKGYKNNPEANKAGFEFGWFHTGDIGYFDTDGYLHLVGRIKELINRGGEKISPIEVDAV 429 V K Y N AN+A F+ GW TGD+GY D +G+L+++ R +LI GGE I P EV++V Sbjct: 345 VMKSYFNRESANEASFQNGWLKTGDLGYLDNEGFLYVLDRRSDLIISGGENIYPAEVESV 404 Query: 430 LLTHPDVSQGVAFGVPDEKYGEEINCAVIPREGTTVTEEDIKAFCKKNLAAFKVPKRVFI 489 LL+HP V++ G D+K+G+ + ++ V+ ++ +CK+ LA +K+P + F+ Sbjct: 405 LLSHPAVAEAGVSGAEDKKWGKVPHAYLVL--HKPVSAGELTDYCKERLAKYKIPAKFFV 462 Query: 490 TDNLPKTASGKIQRRIVAQH 509 D LP+ AS K+ R + Sbjct: 463 LDRLPRNASNKLLRNQLKDA 482 >3A9U-A nrPDB Length = 536 Score = 427 bits (1098), Expect = e-120, Method: Composition-based stats. Identities = 159/515 (30%), Positives = 247/515 (47%), Gaps = 18/515 (3%) Query: 7 SGLLENVAKKFPDRRALSVSGKFNLTHARLHDLIERAASRLVSDAGIKPGDVVALTFPNT 66 S +LEN++ ++ + T+A + R AS L + GI+ GDV+ L P++ Sbjct: 26 SYVLENLSNHSSKPCLINGANGDVYTYADVELTARRVASGL-NKIGIQQGDVIMLFLPSS 84 Query: 67 VEFVIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSKEGNAPAQEAASKLKI 126 EFV+ FL A N T E + S +KLL+T ++ A + Sbjct: 85 PEFVLAFLGASHRGAIITAANPFSTPAELAKHAKASRAKLLITQACYYEKVKDFARE--- 141 Query: 127 SHVTATLLDAGSDLVLSVAD-SDSVVDSATELVNHPDDGALFLHTSGTTSRPKGVPLTQL 185 S V +D+ D L ++ + + + A ++ PDD ++SGTT PKGV LT Sbjct: 142 SDVKVMCVDSAPDGCLHFSELTQADENEAPQVDISPDDVVALPYSSGTTGLPKGVMLTHK 201 Query: 186 NLASSVKNIKAV----YKLTESDSTVIVLPLFHVHGLLAGLLSSLGAGAAVTLPAAGRFS 241 L +SV D + VLP+FH++ L + +L L GA + + +F Sbjct: 202 GLITSVAQQVDGDNPNLYFHSEDVILCVLPMFHIYALNSIMLCGLRVGAPILI--MPKFE 259 Query: 242 ATTFWPDMKKYNATWYTAVPTIHQIILDRHASHPETEYPKLRFIRSCSASLAPVILSRLE 301 + ++KY + VP + I + + + LR I+S A L + + Sbjct: 260 IGSLLGLIEKYKVSIAPVVPPVMMSIA-KSPDLDKHDLSSLRMIKSGGAPLGKELEDTVR 318 Query: 302 EAFG-APVLEAYAMTEATHLMSSN--PLPEEGPHKPGSVGKPV-GQEMAILN-EKGEIQE 356 F A + + Y MTEA +++ E KPG+ G V EM I++ E G Sbjct: 319 AKFPQARLGQGYGMTEAGPVLAMCLAFAKEPFDIKPGACGTVVRNAEMKIVDPETGASLP 378 Query: 357 PNNKGEVCIRGPNVTKGYKNNPEANKAGFE-FGWFHTGDIGYFDTDGYLHLVGRIKELIN 415 N GE+CIRG + KGY N+PEA + GW HTGDIGY D D L +V R+KELI Sbjct: 379 RNQPGEICIRGDQIMKGYLNDPEATSRTIDKEGWLHTGDIGYIDDDDELFIVDRLKELIK 438 Query: 416 RGGEKISPIEVDAVLLTHPDVSQGVAFGVPDEKYGEEINCAVIPREGTTVTEEDIKAFCK 475 G +++P E++A+L+ HP++S G+ DE GE V+ E + TE++IK + Sbjct: 439 YKGFQVAPAELEALLIAHPEISDAAVVGLKDEDAGEVPVAFVVKSEKSQATEDEIKQYIS 498 Query: 476 KNLAAFKVPKRVFITDNLPKTASGKIQRRIVAQHF 510 K + +K KRVF + +PK SGKI R+ + + Sbjct: 499 KQVIFYKRIKRVFFIEAIPKAPSGKILRKNLKEKL 533 >4EAT-A nrPDB Length = 524 Score = 422 bits (1085), Expect = e-118, Method: Composition-based stats. Identities = 134/519 (25%), Positives = 216/519 (41%), Gaps = 21/519 (4%) Query: 5 TLSGLLENVAKKFPDRRALSVSGKFNLTHARLHDLIERAASRLVSDAGIKPGDVVALTFP 64 + L + PD+ A V +L+ A+L + A+ L + G+K + V L Sbjct: 14 NFAEHLLQTNRVRPDKTAF-VDDISSLSFAQLEAQTRQLAAALRA-IGVKREERVLLLML 71 Query: 65 NTVEFVIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLLTS-------KEGNAPA 117 + ++ + FL I A +N TA+++ + L S ++ +L S K + Sbjct: 72 DGTDWPVAFLGAIYAGIVPVAVNTLLTADDYAYMLEHSRAQAVLVSGALHPVLKAALTKS 131 Query: 118 QEAASKLKISHVTATLLDAGSDLVLSVADSDSVVDSATELVNHPDDGALFLHTSGTTSRP 177 ++ +S A L D V + A DD A +L++SG+T RP Sbjct: 132 DHEVQRVIVSRPAAPLEPGEVDFAEFVGAHAPLEKPA---ATQADDPAFWLYSSGSTGRP 188 Query: 178 KGVPLTQLN-LASSVKNIKAVYKLTESDSTVIVLPLFHVHGLLAGLLSSLGAGAAVTLP- 235 KGV T N +S + L E D LF +GL L + GA L Sbjct: 189 KGVVHTHANPYWTSELYGRNTLHLREDDVCFSAAKLFFAYGLGNALTFPMTVGATTLLMG 248 Query: 236 --AAGRFSATTFWPDMKKYNATWYTAVPTIHQIILDRHASHPETEYPKLRFIRSCSASLA 293 + + T + PT + +L + P + LR S +L Sbjct: 249 ERPTPDAVFKRWLGGVGGVKPTVFYGAPTGYAGML-AAPNLPSRDQVALRLASSAGEALP 307 Query: 294 PVILSRLEEAFGAPVLEAYAMTEATHLMSSNPLPEEGPHKPGSVGKPV-GQEMAILNEKG 352 I R + FG +++ TE H+ SN + G+ G PV G ++ + + G Sbjct: 308 AEIGQRFQRHFGLDIVDGIGSTEMLHIFLSN---LPDRVRYGTTGWPVPGYQIELRGDGG 364 Query: 353 EIQEPNNKGEVCIRGPNVTKGYKNNPEANKAGFEFGWFHTGDIGYFDTDGYLHLVGRIKE 412 G++ I GP+ Y N ++ F+ GW +GD + DG GR + Sbjct: 365 GPVADGEPGDLYIHGPSSATMYWGNRAKSRDTFQGGWTKSGDKYVRNDDGSYTYAGRTDD 424 Query: 413 LINRGGEKISPIEVDAVLLTHPDVSQGVAFGVPDEKYGEEINCAVIPREGTTVTEEDIKA 472 ++ G +SP E++A L+ HP V + GV DE + V+PR G T++E ++K Sbjct: 425 MLKVSGIYVSPFEIEATLVQHPGVLEAAVVGVADEHGLTKPKAYVVPRPGQTLSETELKT 484 Query: 473 FCKKNLAAFKVPKRVFITDNLPKTASGKIQRRIVAQHFL 511 F K LA +K P+ LPKTA+GKIQR + + L Sbjct: 485 FIKDRLAPYKYPRSTVFVAELPKTATGKIQRFKLREGVL 523 >3ETC-A nrPDB Length = 580 Score = 422 bits (1084), Expect = e-118, Method: Composition-based stats. Identities = 133/524 (25%), Positives = 227/524 (43%), Gaps = 33/524 (6%) Query: 8 GLLENVAKKFPDRRALSVSGKFN----LTHARLHDLIERAASRLVSDAGIKPGDVVALTF 63 +++ A+ P++ A+ + T L ++AA+ V GI GD V LT Sbjct: 60 DVVDVYARDSPEKLAMIWCDDYGNEKIFTFKDLKYYSDKAANFFV-KHGIGKGDYVMLTL 118 Query: 64 PNTVEFVIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSKEGNAPAQ--EAA 121 + +F L + + A A P + + + + K+++ E + P Q EA Sbjct: 119 KSRYDFWYCMLGLHKLGAIAVPATHMLKTRDIVYRIEKAGLKMIVCIAEDDVPEQVDEAH 178 Query: 122 SK-----LKISHVTATLLDAGSDLVLSVADSDSVVDSAT-ELVNHPDDGALFLHTSGTTS 175 ++ LK + V +L+ D + +S + + T E+ +D L +SGT Sbjct: 179 AECGDIPLKKAKVGGDVLEGWIDFRKELEESSPIFERPTGEVSTKNEDICLVYFSSGTAG 238 Query: 176 RPKGVPLTQLNLASSVKNIKAVYKLTESDSTVIVLPLFHVHGLLAGLLSSLGAGAAVTLP 235 PK V + K + + V + L AG AV + Sbjct: 239 FPKMVEHDNTYPLGHILTAKYWQNVEDDGLHYTVADSGWGKCVWGKLYGQWIAGCAVFVY 298 Query: 236 AAGRFSATTFWPDMKKYNATWYTAVPTIHQIILDRHASHPETEYPKLRFIRSCSASLAPV 295 RF A KY T + A PTI++ ++ SH + L++ L P Sbjct: 299 DYDRFEAKNMLEKASKYGVTTFCAPPTIYRFLIKEDLSH--YNFSTLKYAVVAGEPLNPE 356 Query: 296 ILSRLEEAFGAPVLEAYAMTEATHLMSSNPLPEEGPHKPGSVGKPV-GQEMAILNEKGEI 354 + +R E G ++E + TE +++ P E KPGS+GKP G ++ +++ G + Sbjct: 357 VFNRFLEFTGIKLMEGFGQTETVVTIATFPWMEP---KPGSIGKPTPGYKIELMDRDGRL 413 Query: 355 QEPNNKGEVCIRGPNVTKG--------YKNNPEANKAGFEFGWFHTGDIGYFDTDGYLHL 406 E +GE+ I N +G Y +PE + + G++HTGD+ + D DGYL Sbjct: 414 CEVGEEGEIVI---NTMEGKPVGLFVHYGKDPERTEETWHDGYYHTGDMAWMDEDGYLWF 470 Query: 407 VGRIKELINRGGEKISPIEVDAVLLTHPDVSQGVAFGVPDEKYGEEINCAVIPREGTTVT 466 VGR ++I G K+ P EV++ L+ HP V + GVPD G+ I ++ + T + Sbjct: 471 VGRADDIIKTSGYKVGPFEVESALIQHPAVLECAITGVPDPVRGQVIKATIVLTKDYTPS 530 Query: 467 E---EDIKAFCKKNLAAFKVPKRVFITDNLPKTASGKIQRRIVA 507 + +++ K A +K P+ + LPKT SGKI+R + Sbjct: 531 DSLKNELQDHVKNVTAPYKYPRIIEFVPELPKTISGKIRRVEIR 574 >3IVR-A nrPDB Length = 509 Score = 421 bits (1081), Expect = e-118, Method: Composition-based stats. Identities = 157/519 (30%), Positives = 232/519 (44%), Gaps = 41/519 (7%) Query: 5 TLSGLLENVAKKFPDRRALSVSGKFNLTHARLHDLIERAASRLVSDAGIKPGDVVALTFP 64 TL+ + A FPDR A V G LTH ER AS L+ D G+ GD VA+ Sbjct: 7 TLADVYRRNAALFPDRTAFMVDG-VRLTHRDYLARAERLASGLLRD-GVHTGDRVAILSQ 64 Query: 65 NTVEFVIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSKE------GNAPAQ 118 N E + + AV A P+N A+E F L D +++ + G P+ Sbjct: 65 NCSEMIELIGAVALIGAILLPVNYRLNADEIAFVLGDGAPSVVVAGTDYRDIVAGVLPSL 124 Query: 119 EAASKLKI----SHVTATLLDAGSDLVLSVADSDSVVDSATELVNHPDDGALFLHTSGTT 174 K S A D SD S + + DG + +HT+ Sbjct: 125 GGVKKAYAIGDGSGPFAPFKDLASDTPFSAPEFGAA------------DGFVIIHTAAVG 172 Query: 175 SRPKGVPLTQLNLASSVKNIKAVYKLTESDSTVIVLPLFHVHGLLAGLLSSLGAGAAVTL 234 RP+G ++Q NL + ++ ++LTE+D + +LPLFHV GL L GA+V Sbjct: 173 GRPRGALISQGNLLIAQSSLVDAWRLTEADVNLGMLPLFHVTGLGLMLTLQQAGGASVI- 231 Query: 235 PAAGRFSATTFWPDMKKYNATWYTAVPTIHQIILDRHASHPETEYPKLRFIRSCSASLAP 294 A +F D++ + T + ILD+ A +L +R+ + P Sbjct: 232 --AAKFDPAQAARDIEAHKVTVMAEFAPMLGNILDQAAP------AQLASLRAVTGLDTP 283 Query: 295 VILSRLEEAF-GAPVLEAYAMTEATHLMSSNPLPEEGPHKPGSVGKPVG-QEMAILNEKG 352 + R E A + +E + L + P + +P S G+P+ + +A+++ + Sbjct: 284 ETIERFEATCPNATFWATFGQSETSGLSTFAPYRD----RPKSAGRPLFWRTVAVVDAED 339 Query: 353 EIQEPNNKGEVCIRGPNVTKGYKNNPEANKAGFEFGWFHTGDIGYFDTDGYLHLVGRI-- 410 P GE+ +RGP V KGY NN A + F GW HTGD+G FD DGYL GR Sbjct: 340 RPLPPGEVGEIVLRGPTVFKGYWNNAAATQHAFRNGWHHTGDMGRFDADGYLFYAGRAPE 399 Query: 411 KELINRGGEKISPIEVDAVLLTHPDVSQGVAFGVPDEKYGEEINCAVIPREGTTVTEEDI 470 KELI GGE + P EV+ L HP ++ V GVPD ++ E I + + G ++ + + Sbjct: 400 KELIKTGGENVYPAEVEGALKQHPAIADAVVIGVPDPQWSEAIKAVCVCKPGESIAADAL 459 Query: 471 KAFCKKNLAAFKVPKRVFITDNLPKTASGKIQRRIVAQH 509 F +A +K PK V + LPK A G I R V Sbjct: 460 AEFVASLIARYKKPKHVVFVEALPKDAKGAIDRAAVKTA 498 >4FUQ-A nrPDB Length = 503 Score = 419 bits (1077), Expect = e-117, Method: Composition-based stats. Identities = 158/517 (30%), Positives = 259/517 (50%), Gaps = 22/517 (4%) Query: 1 MDSDTLSGLLENVAKKFPDRRALSVSGKFNLTHARLHDLIERAASRLVSDAGIKPGDVVA 60 M+++ + L + P + A+ + +++A L R A+ LV+ G++ GD VA Sbjct: 1 MNANLFARLFDK--LDDPHKLAIETAAGDKISYAELVARAGRVANVLVAR-GLQVGDRVA 57 Query: 61 LTFPNTVEFVIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSKEGNAPAQEA 120 +VE ++++LA +RA PLN AYT E +++++D++ K+++ Sbjct: 58 AQTEKSVEALVLYLATVRAGGVYLPLNTAYTLHELDYFITDAEPKIVVCDPSKRDGIAAI 117 Query: 121 ASKLKISHVTATLLDAGSDLVLSVADSDSVVDSATELVNH-PDDGALFLHTSGTTSRPKG 179 A+K V AT+ G D S+ D+ + A ++ DD A L+TSGTT R KG Sbjct: 118 AAK-----VGATVETLGPDGRGSLTDAAAGASEAFATIDRGADDLAAILYTSGTTGRSKG 172 Query: 180 VPLTQLNLASSVKNIKAVYKLTESDSTVIVLPLFHVHGLL-AGLLSSLGAGAAVTLPAAG 238 L+ NLAS+ + ++ T D + LP++H HGL A ++ G+ + LP Sbjct: 173 AMLSHDNLASNSLTLVDYWRFTPDDVLIHALPIYHTHGLFVASNVTLFARGSMIFLP--- 229 Query: 239 RFSATTFWPDMKKYNATWYTAVPTIHQIILDRHASHPETEYPKLRFIRSCSASLAPVILS 298 +F M + AT VPT + +L ET +R S SA L Sbjct: 230 KFDPDKILDLMAR--ATVLMGVPTFYTRLLQSPRLTKETTG-HMRLFISGSAPLLADTHR 286 Query: 299 RLEEAFGAPVLEAYAMTEATHLMSSNPLPEEGPHKPGSVGKPV-GQEMAILN-EKGEIQE 356 G VLE Y MTE T++ +SNP +G PG+VG + G + + E G+ Sbjct: 287 EWSAKTGHAVLERYGMTE-TNMNTSNPY--DGDRVPGAVGPALPGVSARVTDPETGKELP 343 Query: 357 PNNKGEVCIRGPNVTKGYKNNPEANKAGF-EFGWFHTGDIGYFDTDGYLHLVGRIKELIN 415 + G + ++GPNV KGY PE K+ F + G+F TGD+G D GY+H++GR K+L+ Sbjct: 344 RGDIGMIEVKGPNVFKGYWRMPEKTKSEFRDDGFFITGDLGKIDERGYVHILGRGKDLVI 403 Query: 416 RGGEKISPIEVDAVLLTHPDVSQGVAFGVPDEKYGEEINCAVIPREGTTVTEEDIKAFCK 475 GG + P E+++ + P V + GVP +GE + V+ +G T+ E + Sbjct: 404 TGGFNVYPKEIESEIDAMPGVVESAVIGVPHADFGEGVTAVVVRDKGATIDEAQVLHGLD 463 Query: 476 KNLAAFKVPKRVFITDNLPKTASGKIQRRIVAQHFLE 512 LA FK+PK+V D+LP+ GK+Q+ ++ + + + Sbjct: 464 GQLAKFKMPKKVIFVDDLPRNTMGKVQKNVLRETYKD 500 >5DWV-A nrPDB Length = 573 Score = 419 bits (1077), Expect = e-117, Method: Composition-based stats. Identities = 135/528 (25%), Positives = 232/528 (43%), Gaps = 29/528 (5%) Query: 4 DTLSGLLENVAKKFPDRRALSVSG-KFNLTHARLHDLIERAASRLVSDAGIKPGDVVALT 62 + L ++ A P A + + + N+T+A ++ R A + G+ + + Sbjct: 47 EQLHKAMKRYA-LVPGTIAFTDAHIEVNITYAEYFEMSVRLAEAM-KRYGLNTNHRIVVC 104 Query: 63 FPNTVEFVIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSKEGNAPAQEAAS 122 N+++F + L + AP N Y E ++ S ++ SK+G Sbjct: 105 SENSLQFFMPVLGALFIGVAVAPANDIYNERELLNSMNISQPTVVFVSKKGLQKILNVQK 164 Query: 123 KLKISHVTATLLDAGSDL-----VLSVADSDSVV-----DSATELVNHPDDGALFLHTSG 172 KL I ++D+ +D + + S D E + AL +++SG Sbjct: 165 KLPIIQ-KIIIMDSKTDYQGFQSMYTFVTSHLPPGFNEYDFVPESFDRDKTIALIMNSSG 223 Query: 173 TTSRPKGVPLTQLNL---ASSVKNIKAVYKLTESDSTVIVLPLFHVHGLLAGLLSSLGAG 229 +T PKGV L S ++ ++ + + V+P H G+ L L G Sbjct: 224 STGLPKGVALPHRTACVRFSHARDPIFGNQIIPDTAILSVVPFHHGFGMFT-TLGYLICG 282 Query: 230 AAVTLPAAGRFSATTFWPDMKKYNATWYTAVPTIHQIILDRHASHPETEYPKLRFIRSCS 289 V L RF F ++ Y VPT+ + + + L I S Sbjct: 283 FRVVL--MYRFEEELFLRSLQDYKIQSALLVPTLFSF-FAKSTLIDKYDLSNLHEIASGG 339 Query: 290 ASLAPVILSRLEEAFGAP-VLEAYAMTEATHLMSSNPLPEEGPHKPGSVGK--PVGQEMA 346 A L+ + + + F P + + Y +TE T + P EG KPG+VGK P + Sbjct: 340 APLSKEVGEAVAKRFHLPGIRQGYGLTETTSAILITP---EGDDKPGAVGKVVPFFEAKV 396 Query: 347 ILNEKGEIQEPNNKGEVCIRGPNVTKGYKNNPEANKAGFE-FGWFHTGDIGYFDTDGYLH 405 + + G+ N +GE+C+RGP + GY NNPEA A + GW H+GDI Y+D D + Sbjct: 397 VDLDTGKTLGVNQRGELCVRGPMIMSGYVNNPEATNALIDKDGWLHSGDIAYWDEDEHFF 456 Query: 406 LVGRIKELINRGGEKISPIEVDAVLLTHPDVSQGVAFGVPDEKYGEEINCAVIPREGTTV 465 +V R+K LI G +++P E++++LL HP++ G+PD+ GE V+ G T+ Sbjct: 457 IVDRLKSLIKYKGYQVAPAELESILLQHPNIFDAGVAGLPDDDAGELPAAVVVLEHGKTM 516 Query: 466 TEEDIKAFCKKNL-AAFKVPKRVFITDNLPKTASGKIQRRIVAQHFLE 512 TE++I + + A K+ V D +PK +GK+ R + + ++ Sbjct: 517 TEKEIVDYVASQVTTAKKLRGGVVFVDEVPKGLTGKLDARKIREILIK 564 >1MDF-A nrPDB Length = 539 Score = 419 bits (1076), Expect = e-117, Method: Composition-based stats. Identities = 140/524 (26%), Positives = 235/524 (44%), Gaps = 30/524 (5%) Query: 4 DTLSGLLENVAKKFPDRRALSVSGKFNLTHARLHDLIERAASRLVSDAGIKPGDVVALTF 63 +T LL + A K+ DR A++ G + ++ L +R A+ GI+ D V + Sbjct: 25 ETFGDLLRDRAAKYGDRIAITC-GNTHWSYRELDTRADRLAAGF-QKLGIQQKDRVVVQL 82 Query: 64 PNTVEFVIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLL-----TSKEGNAPAQ 118 PN EF + A+ R A ++ + E ++ +++ + + + + A+ Sbjct: 83 PNIKEFFEVIFALFRLGALPVFALPSHRSSEITYFCEFAEAAAYIIPDAYSGFDYRSLAR 142 Query: 119 EAASKLKISHVTATLLDAGSDLVLSVADSDSVVDSATELVNHPD----DGALFLHTSGTT 174 + SKL +A L L D TE V P+ D A + G+T Sbjct: 143 QVQSKLPTLKNIIVAGEAEEFLPLE--------DLHTEPVKLPEVKSSDVAFLQLSGGST 194 Query: 175 SRPKGVPLTQLNLASSVKNIKAVYKLTESDSTVIVLPLFHVHGLLA-GLLSSLGAGAAVT 233 K +P T + S+K V L S + LP+ H + L + G+L L AG V Sbjct: 195 GLSKLIPRTHDDYIYSLKRSVEVCWLDHSTVYLAALPMAHNYPLSSPGVLGVLYAGGRVV 254 Query: 234 LPAAGRFSATTFWPDMKKYNATWYTAVPTIHQIILDRHASHPETEYPKLRFIRSCSASLA 293 L + S +P +++ T VP + + +D AS + L+ ++ A + Sbjct: 255 LSPSP--SPDDAFPLIEREKVTITALVPPLAMVWMD-AASSRRDDLSSLQVLQVGGAKFS 311 Query: 294 PVILSRLEEAFGAPVLEAYAMTEATHLMSSNPLPEEGPHKPGSVGKPVG--QEMAILNEK 351 R++ FG + + + M E L++ L + + GKP+ E + ++ Sbjct: 312 AEAARRVKAVFGCTLQQVFGMAE--GLVNYTRLDDPEEIIVNTQGKPMSPYDESRVWDDH 369 Query: 352 GEIQEPNNKGEVCIRGPNVTKGYKNNPEANKAGF-EFGWFHTGDIGYFDTDGYLHLVGRI 410 +P G + RGP +GY E N A F E G++ TGDI DGY+ + GR Sbjct: 370 DRDVKPGETGHLLTRGPYTIRGYYKAEEHNAASFTEDGFYRTGDIVRLTRDGYIVVEGRA 429 Query: 411 KELINRGGEKISPIEVDAVLLTHPDVSQGVAFGVPDEKYGEEINCAVIPREGTTVTEEDI 470 K+ INRGGEK++ EV+ LL HP V +PD+ GE +IPR+ ++ Sbjct: 430 KDQINRGGEKVAAEEVENHLLAHPAVHDAAMVSMPDQFLGERSCVFIIPRDEA-PKAAEL 488 Query: 471 KAFCKKN-LAAFKVPKRVFITDNLPKTASGKIQRRIVAQHFLEK 513 KAF ++ LAA+K+P RV ++ P+T GK+ ++ + + EK Sbjct: 489 KAFLRERGLAAYKIPDRVEFVESFPQTGVGKVSKKALREAISEK 532 >3GPC-A nrPDB Length = 570 Score = 417 bits (1072), Expect = e-117, Method: Composition-based stats. Identities = 118/516 (22%), Positives = 204/516 (39%), Gaps = 20/516 (3%) Query: 7 SGLLENVAKKFPDRRALSVSGKFNLTHARLHDLIE---RAASRLVSDAGIKPGDVVALTF 63 +E K+ P V+GK +L E +AA+ L G++ GD VA+ Sbjct: 47 WADMEKAGKRPPSPALWWVNGKGKELMWNFRELSENSQQAANVLSGACGLQRGDRVAVVL 106 Query: 64 PNTVEFVIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSKEGNAPAQEAASK 123 P E+ ++ L IRA P + + + L S +K ++ E AS+ Sbjct: 107 PRVPEWWLVILGCIRAGLIFMPGTIQMKSTDILYRLQMSKAKAIVAGDEVIQEVDTVASE 166 Query: 124 LKISHVTATLLDAGSDLVLSVADSDSVVDSATELV-NHPDDGALFLHTSGTTSRPKGVPL 182 + + + D L+ + + V + + TSGT+ PK Sbjct: 167 CPSLRIKLLVSEKSCDGWLNFKKLLNEASTTHHCVETGSQEASAIYFTSGTSGLPKMAEH 226 Query: 183 TQLNLASSVKNIKAVYKLTESDSTVIVLPLFHVHGLLAGLLSSLGAGAAVTLPAAGRFSA 242 + +L K L SD + + +L L+ GA + +F Sbjct: 227 SYSSLGLKAKMDAGWTGLQASDIMWTISDTGWILNILCSLMEPWALGACTFVHLLPKFDP 286 Query: 243 TTFWPDMKKYNATWYTAVPTIHQIILDRHASHPETEYPKLRFIRSCSASLAPVILSRLEE 302 + Y P +++++L + S ++P L+ + SL P L Sbjct: 287 LVILKTLSSYPIKSMMGAPIVYRMLLQQDLS--SYKFPHLQNCVTVGESLLPETLENWRA 344 Query: 303 AFGAPVLEAYAMTEATHLMSSNPLPEEGPHKPGSVGKPVG-QEMAILNEKGEIQEPNNKG 361 G + E+Y TE + + + KPG +G ++ I+++KG + P +G Sbjct: 345 QTGLDIRESYGQTETGL---TCMVSKTMKIKPGYMGTAASCYDVQIIDDKGNVLPPGTEG 401 Query: 362 EVCIRGP-----NVTKGYKNNPEANKAGFEFGWFHTGDIGYFDTDGYLHLVGRIKELINR 416 ++ IR + GY +NP+ A ++ GD G D DGY +GR ++IN Sbjct: 402 DIGIRVKPIRPIGIFSGYVDNPDKTAANIRGDFWLLGDRGIKDEDGYFQFMGRADDIINS 461 Query: 417 GGEKISPIEVDAVLLTHPDVSQGVAFGVPDEKYGEEINCAVI-----PREGTTVTEEDIK 471 G +I P EV+ L+ HP V + PD GE + V+ ++++ Sbjct: 462 SGYRIGPSEVENALMEHPAVVETAVISSPDPVRGEVVKAFVVLASQFLSHDPEQLTKELQ 521 Query: 472 AFCKKNLAAFKVPKRVFITDNLPKTASGKIQRRIVA 507 K A +K P+++ NLPKT +GKIQR + Sbjct: 522 QHVKSVTAPYKYPRKIEFVLNLPKTVTGKIQRAKLR 557 >5JRH-A nrPDB Length = 660 Score = 411 bits (1055), Expect = e-115, Method: Composition-based stats. Identities = 130/543 (23%), Positives = 216/543 (39%), Gaps = 45/543 (8%) Query: 7 SGLLENVAKKFPDRRALSVSGKF-----NLTHARLHDLIERAASRLVSDAGIKPGDVVAL 61 + L+ ++ DR A+ G ++++ LH + R A+ L+ D GIK GDVVA+ Sbjct: 79 ANCLDRHLQENGDRTAIIWEGDDTSQSKHISYRELHRDVCRFANTLL-DLGIKKGDVVAI 137 Query: 62 TFPNTVEFVIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSKEGNAPAQEAA 121 P E + LA R A + + ++ E + DS S+L++T+ EG + Sbjct: 138 YMPMVPEAAVAMLACARIGAVHSVIFGGFSPEAVAGRIIDSSSRLVITADEGVRAGRSIP 197 Query: 122 SKLKISH-----------VTATLLDAGSDLVLSVADSDSVVD-------SATELVNHPDD 163 K + L GSD+ D + +D Sbjct: 198 LKKNVDDALKNPNVTSVEHVIVLKRTGSDIDWQEGRDLWWRDLIEKASPEHQPEAMNAED 257 Query: 164 GALFLHTSGTTSRPKGVPLTQL-NLASSVKNIKAVYKLTESDSTVIVLPLFHVHGLLAGL 222 L+TSG+T +PKGV T L + K V+ D + V G L Sbjct: 258 PLFILYTSGSTGKPKGVLHTTGGYLVYAATTFKYVFDYHPGDIYWCTADVGWVTGHSYLL 317 Query: 223 LSSLGAGAAVTLP--AAGRFSATTFWPDMKKYNATWYTAVPTIHQIILDRHASHPE-TEY 279 L GA + + + K+ PT + ++ E T+ Sbjct: 318 YGPLACGATTLMFEGVPNWPTPARMCQVVDKHQVNILYTAPTAIRALMAEGDKAIEGTDR 377 Query: 280 PKLRFIRSCSASLAPVILSRLEEAFG---APVLEAYAMTEATHLMSSNPLPEEGPHKPGS 336 LR + S + P + G PV++ + TE M PLP K GS Sbjct: 378 SSLRILGSVGEPINPEAWEWYWKKIGKEKCPVVDTWWQTETGGFM-ITPLPGAIELKAGS 436 Query: 337 VGKPV-GQEMAILNEKGEIQEPNNKGEVCIRGPNVTKGYKNNPEANKAGFEFGWFHT--- 392 +P G + A+++ +G QE +G + I + G + FE +F T Sbjct: 437 ATRPFFGVQPALVDNEGHPQEGATEGNLVIT--DSWPGQARTLFGDHERFEQTYFSTFKN 494 Query: 393 ----GDIGYFDTDGYLHLVGRIKELINRGGEKISPIEVDAVLLTHPDVSQGVAFGVPDEK 448 GD D DGY + GR+ +++N G ++ E+++ L+ HP +++ G+P Sbjct: 495 MYFSGDGARRDEDGYYWITGRVDDVLNVSGHRLGTAEIESALVAHPKIAEAAVVGIPHAI 554 Query: 449 YGEEINCAVIPREGTTVTEE---DIKAFCKKNLAAFKVPKRVFITDNLPKTASGKIQRRI 505 G+ I V G + E +++ + +K + P + TD+LPKT SGKI RRI Sbjct: 555 KGQAIYAYVTLNHGEEPSPELYAEVRNWVRKEIGPLATPDVLHWTDSLPKTRSGKIMRRI 614 Query: 506 VAQ 508 + + Sbjct: 615 LRK 617 >3TSY-A nrPDB Length = 979 Score = 408 bits (1048), Expect = e-114, Method: Composition-based stats. Identities = 148/521 (28%), Positives = 239/521 (45%), Gaps = 24/521 (4%) Query: 8 GLLENVAKKFPDRRALSVSGKFNLTHARLHDLIERAASRLVSDAGIKPGDVVALTFPNTV 67 + +N+++ ++ T++ +H + + A+ G+ DVV L PN Sbjct: 66 YIFQNISEFATKPCLINGPTGHVYTYSDVHVISRQIAANF-HKLGVNQNDVVMLLLPNCP 124 Query: 68 EFVIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSKEGNAPAQEAASKLKIS 127 EFV+ FLA ATA N +T E S++KL++T + + + Sbjct: 125 EFVLSFLAASFRGATATAANPFFTPAEIAKQAKASNTKLIITEARYVDKIKPLQNDDGV- 183 Query: 128 HVTATLLDAG----SDLVLSVADSDSVVDSATELVNH----PDDGALFLHTSGTTSRPKG 179 V + D + L + A+E+++ PDD ++SGTT PKG Sbjct: 184 -VIVCIDDNESVPIPEGCLRFTELTQSTTEASEVIDSVEISPDDVVALPYSSGTTGLPKG 242 Query: 180 VPLTQLNLASSVKNIKAV----YKLTESDSTVIVLPLFHVHGLLAGLLSSLGAGAAVTLP 235 V LT L +SV D + VLP+FH++ L + +L L GAA+ + Sbjct: 243 VMLTHKGLVTSVAQQVDGENPNLYFHSDDVILCVLPMFHIYALNSIMLCGLRVGAAILI- 301 Query: 236 AAGRFSATTFWPDMKKYNATWYTAVPTIHQIILDRHASHPETEYPKLRFIRSCSASLAPV 295 +F +++ T VP I I + + +R ++S +A L Sbjct: 302 -MPKFEINLLLELIQRCKVTVAPMVPPIVLAIAKSSETEK-YDLSSIRVVKSGAAPLGKE 359 Query: 296 ILSRLEEAF-GAPVLEAYAMTEATH--LMSSNPLPEEGPHKPGSVGKPV-GQEMAILN-E 350 + + F A + + Y MTEA MS E P K G+ G V EM I++ + Sbjct: 360 LEDAVNAKFPNAKLGQGYGMTEAGPVLAMSLGFAKEPFPVKSGACGTVVRNAEMKIVDPD 419 Query: 351 KGEIQEPNNKGEVCIRGPNVTKGYKNNPEANKAGFE-FGWFHTGDIGYFDTDGYLHLVGR 409 G+ N GE+CIRG + KGY NNP A + GW HTGDIG D D L +V R Sbjct: 420 TGDSLSRNQPGEICIRGHQIMKGYLNNPAATAETIDKDGWLHTGDIGLIDDDDELFIVDR 479 Query: 410 IKELINRGGEKISPIEVDAVLLTHPDVSQGVAFGVPDEKYGEEINCAVIPREGTTVTEED 469 +KELI G +++P E++A+L+ HPD++ + +E GE V+ + + ++E+D Sbjct: 480 LKELIKYKGFQVAPAELEALLIGHPDITDVAVVAMKEEAAGEVPVAFVVKSKDSELSEDD 539 Query: 470 IKAFCKKNLAAFKVPKRVFITDNLPKTASGKIQRRIVAQHF 510 +K F K + +K +VF T+++PK SGKI R+ + Sbjct: 540 VKQFVSKQVVFYKRINKVFFTESIPKAPSGKILRKDLRAKL 580 >1RY2-A nrPDB Length = 663 Score = 405 bits (1041), Expect = e-113, Method: Composition-based stats. Identities = 124/550 (22%), Positives = 240/550 (43%), Gaps = 51/550 (9%) Query: 8 GLLENVAKKFPDRRALSVSGK-----FNLTHARLHDLIERAASRLVSDAGIKPGDVVALT 62 ++ A K P+++A+ G +++T+ L + + + A L G++ GD VA+ Sbjct: 86 NCVDRHALKTPNKKAIIFEGDEPGQGYSITYKELLEEVCQVAQVLTYSMGVRKGDTVAVY 145 Query: 63 FPNTVEFVIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSKEGNAPAQEAAS 122 P E +I LA+ R A + + A +++ ++D DSK+++T+ E N + + Sbjct: 146 MPMVPEAIITLLAISRIGAIHSVVFAGFSSNSLRDRINDGDSKVVITTDESNRGGKVIET 205 Query: 123 KLKISHVTATLLDAGSDLVLSVADSDSVV-------DSATELVNH----------PDDGA 165 K + LV ++ SV D ATE + +D Sbjct: 206 KRIVDDALRETPGVRHVLVYRKTNNPSVAFHAPRDLDWATEKKKYKTYYPCTPVDSEDPL 265 Query: 166 LFLHTSGTTSRPKGVPL-TQLNLASSVKNIKAVYKLTESDSTVIVLPLFHVHGLLAGLLS 224 L+TSG+T PKGV T L ++ ++ + + D + + G + Sbjct: 266 FLLYTSGSTGAPKGVQHSTAGYLLGALLTMRYTFDTHQEDVFFTAGDIGWITGHTYVVYG 325 Query: 225 SLGAGAAVTL----PAAGRFSATTFWPDMKKYNATWYTAVPTIHQIILDRHASHPETE-Y 279 L G A + PA +S +W + ++ T + PT +++ S+ E Sbjct: 326 PLLYGCATLVFEGTPAYPNYS--RYWDIIDEHKVTQFYVAPTALRLLKRAGDSYIENHSL 383 Query: 280 PKLRFIRSCSASLAPVILSRLEEAFGA---PVLEAYAMTEATHLMSSNPLPEEGPHKPGS 336 LR + S +A + E G P+++ Y TE+ + + P KPGS Sbjct: 384 KSLRCLGSVGEPIAAEVWEWYSEKIGKNEIPIVDTYWQTESGSHLVTPLAGGVTPMKPGS 443 Query: 337 VGKP-VGQEMAILNEKGEIQ--EPNNKGEVCIRG--PNVTKGYKNNPEANKAGF---EFG 388 P G + +L+ + + +G + ++ P+ + N + + G Sbjct: 444 ASFPFFGIDAVVLDPNTGEELNTSHAEGVLAVKAAWPSFARTIWKNHDRYLDTYLNPYPG 503 Query: 389 WFHTGDIGYFDTDGYLHLVGRIKELINRGGEKISPIEVDAVLLTHPDVSQGVAFGVPDEK 448 ++ TGD D DGY+ ++GR+ +++N G ++S E++A ++ P V++ G D+ Sbjct: 504 YYFTGDGAAKDKDGYIWILGRVDDVVNVSGHRLSTAEIEAAIIEDPIVAECAVVGFNDDL 563 Query: 449 YGEEINCAVIPRE---GTTVTEEDIKAF-------CKKNLAAFKVPKRVFITDNLPKTAS 498 G+ + V+ + +T T+++++ +K++ F PK + + D+LPKT S Sbjct: 564 TGQAVAAFVVLKNKSSWSTATDDELQDIKKHLVFTVRKDIGPFAAPKLIILVDDLPKTRS 623 Query: 499 GKIQRRIVAQ 508 GKI RRI+ + Sbjct: 624 GKIMRRILRK 633 >2D1S-A nrPDB Length = 548 Score = 405 bits (1041), Expect = e-113, Method: Composition-based stats. Identities = 144/536 (26%), Positives = 239/536 (44%), Gaps = 33/536 (6%) Query: 1 MDSDTLSGLLENVAKKFPDRRALSVSGKF---NLTHARLHDLIERAASRLVSDAGIKPGD 57 ++ + L +++ A++ + + ++A + L + G+ Sbjct: 20 IEEGSAGTQLRKYMERYAKLGAIAFTNAVTGVDYSYAEYLEKSCCLGKAL-QNYGLVVDG 78 Query: 58 VVALTFPNTVEFVIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSKEGNAPA 117 +AL N EF I +A + AP N YT E L S ++ +SK+G Sbjct: 79 RIALCSENCEEFFIPVIAGLFIGVGVAPTNEIYTLRELVHSLGISKPTIVFSSKKGLDKV 138 Query: 118 QEAASKLKISHVTATLLDAGSDLVLSVADSDSVVDSATEL-----------VNHPDDGAL 166 + T +LD+ D D+ + T V+ + AL Sbjct: 139 ITVQKTVTTIK-TIVILDSKVDYR-GYQCLDTFIKRNTPPGFQASSFKTVEVDRKEQVAL 196 Query: 167 FLHTSGTTSRPKGVPLTQLNLASSVKNIKA---VYKLTESDSTVIVLPLFHVHGLLAGLL 223 +++SG+T PKGV LT N+ + + + +++ + + V+P H G+ L Sbjct: 197 IMNSSGSTGLPKGVQLTHENIVTRFSHARDPIYGNQVSPGTAVLTVVPFHHGFGMFT-TL 255 Query: 224 SSLGAGAAVTLPAAGRFSATTFWPDMKKYNATWYTAVPTIHQIILDRHASHPETEYPKLR 283 L G V + +F TF ++ Y T VPT+ IL++ + + L Sbjct: 256 GYLICGFRVVMLT--KFDEETFLKTLQDYKCTSVILVPTLFA-ILNKSELLNKYDLSNLV 312 Query: 284 FIRSCSASLAPVILSRLEEAFGAP-VLEAYAMTEATHLMSSNPLPEEGPHKPGSVGK--P 340 I S A L+ + + F P V + Y +TE T + P EG KPG+ GK P Sbjct: 313 EIASGGAPLSKEVGEAVARRFNLPGVRQGYGLTETTSAIIITP---EGDDKPGASGKVVP 369 Query: 341 VGQEMAILNEKGEIQEPNNKGEVCIRGPNVTKGYKNNPEANKAGFEF-GWFHTGDIGYFD 399 + + I + + PN +GEVC++GP + KGY NNPEA K + GW HTGDIGY+D Sbjct: 370 LFKAKVIDLDTKKSLGPNRRGEVCVKGPMLMKGYVNNPEATKELIDEEGWLHTGDIGYYD 429 Query: 400 TDGYLHLVGRIKELINRGGEKISPIEVDAVLLTHPDVSQGVAFGVPDEKYGEEINCAVIP 459 + + +V R+K LI G ++ P E+++VLL HP + GVPD GE V+ Sbjct: 430 EEKHFFIVDRLKSLIKYKGYQVPPAELESVLLQHPSIFDAGVAGVPDPVAGELPGAVVVL 489 Query: 460 REGTTVTEEDIKAFCKKNLA-AFKVPKRVFITDNLPKTASGKIQRRIVAQHFLEKP 514 G +TE+++ + ++ A ++ V D +PK +GKI R + + L+KP Sbjct: 490 ESGKNMTEKEVMDYVASQVSNAKRLRGGVRFVDEVPKGLTGKIDGRAIRE-ILKKP 544 >2V7B-A nrPDB Length = 529 Score = 405 bits (1040), Expect = e-113, Method: Composition-based stats. Identities = 133/513 (25%), Positives = 220/513 (42%), Gaps = 15/513 (2%) Query: 5 TLSGLLENVAKKFPDRRALSVSGKFNLTHARLHDLIERAASRLVSDAGIKPGDVVALTFP 64 + L + + + A + T+ L + R AS L G+ P + + L Sbjct: 24 NFAAYLFRLNETRAGKTAYI-DDTGSTTYGELEERARRFASAL-RTLGVHPEERILLVML 81 Query: 65 NTVEFVIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSKEGNAPAQEAASKL 124 +TV + FL + A N T ++ + L+ S ++ ++ S +A Sbjct: 82 DTVALPVAFLGALYAGVVPVVANTLLTPADYVYMLTHSHARAVIASGALVQNVTQALESA 141 Query: 125 KISH----VTATLLDAGSDLVLSVADSDSVVDSATELVNHPDDGALFLHTSGTTSRPKGV 180 + V+ L D+ +A DD A +L++SG+T +PKG Sbjct: 142 EHDGCQLIVSQPRESEPRLAPLFEELIDAAAPAAKAAATGCDDIAFWLYSSGSTGKPKGT 201 Query: 181 PLTQLNLASSVK-NIKAVYKLTESDSTVIVLPLFHVHGLLAGLLSSLGAGAAVTLPAAGR 239 T NL + + K + + E+D LF +GL GL L GA L A R Sbjct: 202 VHTHANLYWTAELYAKPILGIAENDVVFSAAKLFFAYGLGNGLTFPLSVGATAILM-AER 260 Query: 240 FSATTFWPDMKKYNATWYTAVPTIHQIILDRHASHPETEYPKLRFIRSCSASLAPVILSR 299 +A + + ++ T + VPT++ +L + P +R S +L I R Sbjct: 261 PTADAIFARLVEHRPTVFYGVPTLYANML-VSPNLPARADVAIRICTSAGEALPREIGER 319 Query: 300 LEEAFGAPVLEAYAMTEATHLMSSNPLPEEGPHKPGSVGKPV-GQEMAILNEKGEIQEPN 358 FG +L+ TE H+ SN G + G+ G+PV G E+ + +E G Sbjct: 320 FTAHFGCEILDGIGSTEMLHIFLSN---RAGAVEYGTTGRPVPGYEIELRDEAGHAVPDG 376 Query: 359 NKGEVCIRGPNVTKGYKNNPEANKAGFEFGWFHTGDIGYFDTDGYLHLVGRIKELINRGG 418 G++ I+GP+ Y NN E ++A F W +GD +G GR +++ G Sbjct: 377 EVGDLYIKGPSAAVMYWNNREKSRATFLGEWIRSGDKYCRLPNGCYVYAGRSDDMLKVSG 436 Query: 419 EKISPIEVDAVLLTHPDVSQGVAFGVPDEKYGEEINCAVIPRE--GTTVTEEDIKAFCKK 476 + +SP+EV+ VL+ H V + GV + V+ RE + + E++KAF K Sbjct: 437 QYVSPVEVEMVLVQHDAVLEAAVVGVDHGGLVKTRAFVVLKREFAPSEILAEELKAFVKD 496 Query: 477 NLAAFKVPKRVFITDNLPKTASGKIQRRIVAQH 509 LA K P+ + D+LPKTA+GKIQR + + Sbjct: 497 RLAPHKYPRDIVFVDDLPKTATGKIQRFKLREQ 529 >3O84-A nrPDB Length = 544 Score = 402 bits (1032), Expect = e-112, Method: Composition-based stats. Identities = 122/516 (23%), Positives = 239/516 (46%), Gaps = 20/516 (3%) Query: 3 SDTLSGLLENVAKKFPDRRALSVSGKFNLTHARLHDLIERAASRLVSDAGIKPGDVVALT 62 L+ +L + P A+ G+ L++ L L A+RL ++ G+ GD + Sbjct: 29 DQPLTRILTVGVQSHPHSLAIIC-GERQLSYIELDRLSTNLATRL-AEKGLGKGDTALVQ 86 Query: 63 FPNTVEFVIMFLAVIRARATAAPLNAAYTAEEFEF--YLSDSDSKLLLTSKE----GNAP 116 PN EF I+F A+++A LNA Y+ ++E ++ KLL+ S++ N Sbjct: 87 LPNVAEFYIVFFALLKAGVVV--LNALYSHRQYELNAFIKQIQPKLLIGSRQHEVFSNNQ 144 Query: 117 AQEAASKLKISHVTATLLDAGSDLVLSVADSDSVVDSATELVNHP-DDGALFLHTSGTTS 175 ++ + +S +L+ + + ++ ++ + + P D+ A F + G+T Sbjct: 145 FIDSLHDVNLSPEIILMLNHQATDFGLLDWIETPAETFVDFSSTPADEVAFFQLSGGSTG 204 Query: 176 RPKGVPLTQLNLASSVKNIKAVYKLTESDSTVIVLPLFHVHGLLA-GLLSSLGAGAAVTL 234 PK +P T + SV+ + L + + LP H L + G L L AG V + Sbjct: 205 TPKLIPRTHNDYDYSVRASAEICGLNSNTRLLCALPAPHNFMLSSPGALGVLHAGGCVVM 264 Query: 235 PAAGRFSATTFWPDMKKYNATWYTAVPTIHQIILDRHASHPETEYPKLRFIRSCSASLAP 294 A + ++++ + VP+ + L++ A + + + L+ ++ AS Sbjct: 265 --APNPEPLNCFSIIQRHQVNMASLVPSAVIMWLEKAAQYKD-QIQSLKLLQVGGASFPE 321 Query: 295 VILSRLEEAFGAPVLEAYAMTEATHLMSSNPLPEEGPHKPGSVGKPV--GQEMAILNEKG 352 + ++ E + + + M E L++ L + + G+P+ E+ I++E+ Sbjct: 322 SLARQVPEVLNCKLQQVFGMAE--GLVNYTRLDDSDEQIFTTQGRPISSDDEIKIVDEQY 379 Query: 353 EIQEPNNKGEVCIRGPNVTKGYKNNPEANKAGFE-FGWFHTGDIGYFDTDGYLHLVGRIK 411 G + RGP GY +PE N F+ ++++GD+ DG L +VGRIK Sbjct: 380 REVPEGEIGMLATRGPYTFCGYYQSPEHNSQVFDEDNYYYSGDLVQRTPDGNLRVVGRIK 439 Query: 412 ELINRGGEKISPIEVDAVLLTHPDVSQGVAFGVPDEKYGEEINCAVIPREGTTVTEEDIK 471 + INRGGEKI+ E++ ++L HP+V + DE++GE+ ++ R + Sbjct: 440 DQINRGGEKIASEEIEKLILLHPEVMHAALVAIVDEQFGEKSCAFIVSRNPELKAVVLRR 499 Query: 472 AFCKKNLAAFKVPKRVFITDNLPKTASGKIQRRIVA 507 + +A +K+P ++ + ++LP TA GK+ ++ + Sbjct: 500 HLMELGIAQYKLPDQIKLIESLPLTAVGKVDKKQLR 535 >1V25-A nrPDB Length = 541 Score = 397 bits (1019), Expect = e-111, Method: Composition-based stats. Identities = 133/531 (25%), Positives = 232/531 (43%), Gaps = 31/531 (5%) Query: 1 MDSD-TLSGLLENVAKKFPDRRALSV--SGKFN-LTHARLHDLIERAASRLVSDAGIKPG 56 MD + L LE A F + +S +G+ + T+A ++ R L + G+ G Sbjct: 14 MDEELNLWDFLERAAALFGRKEVVSRLHTGEVHRTTYAEVYQRARRLMGGLRA-LGVGVG 72 Query: 57 DVVALTFPNTVEFVIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSKEGNAP 116 D VA N + + AV A N + +E + L+ ++ K+LL Sbjct: 73 DRVATLGFNHFRHLEAYFAVPGMGAVLHTANPRLSPKEIAYILNHAEDKVLLFDPNLLPL 132 Query: 117 AQEAASKLKISHVTATLLDAGSDLVLSVADSDSVVDSATELVNHPDDGALFL-HTSGTTS 175 + +LK + + + L+ ++ + + V P+ A + +T+GTT Sbjct: 133 VEAIRGELKTVQHFVVMDEKAPEGYLAYEEA---LGEEADPVRVPERAACGMAYTTGTTG 189 Query: 176 RPKGVPLTQLNLA--SSVKNIKAVYKLTESDSTVIVLPLFHVHGLLAGLLSSLGAGAAVT 233 PKGV + L S ++ L+E D + V+P+FHV+ ++L GA Sbjct: 190 LPKGVVYSHRALVLHSLAASLVDGTALSEKDVVLPVVPMFHVNAWCLPYAATL-VGAKQV 248 Query: 234 LPAAGRFSATTFWPDMKKYNATWYTAVPTIHQIILDRHASHPETEYPKLRFIR--SCSAS 291 LP R + T+ VPT+ + D + E+ +L+ +R S Sbjct: 249 LPG-PRLDPASLVELFDGEGVTFTAGVPTVWLALAD----YLESTGHRLKTLRRLVVGGS 303 Query: 292 LAPVILSRLEEAFGAPVLEAYAMTEATHLMSSNPL--------PEEGPHKPGSVGKPVG- 342 AP L E G V + Y +TE + ++ N + EE G P+ Sbjct: 304 AAPRSLIARFERMGVEVRQGYGLTETSPVVVQNFVKSHLESLSEEEKLTLKAKTGLPIPL 363 Query: 343 QEMAILNEKGEIQEPNNK--GEVCIRGPNVTKGYKNNPEANKAGF-EFGWFHTGDIGYFD 399 + + +E+G + K GEV ++GP +T GY N EA ++ G+F TGDI +D Sbjct: 364 VRLRVADEEGRPVPKDGKALGEVQLKGPWITGGYYGNEEATRSALTPDGFFRTGDIAVWD 423 Query: 400 TDGYLHLVGRIKELINRGGEKISPIEVDAVLLTHPDVSQGVAFGVPDEKYGEEINCAVIP 459 +GY+ + R+K+LI GGE IS ++++ L+ HP V + +P K+ E V+P Sbjct: 424 EEGYVEIKDRLKDLIKSGGEWISSVDLENALMGHPKVKEAAVVAIPHPKWQERPLAVVVP 483 Query: 460 REGTTVTEEDIKAFCKKNLAAFKVPKRVFITDNLPKTASGKIQRRIVAQHF 510 R EE + K A +++P + +P+T++GK +R + + + Sbjct: 484 RGEKPTPEELNEHLLKAGFAKWQLPDAYVFAEEIPRTSAGKFLKRALREQY 534 >5ES8-A nrPDB Length = 776 Score = 392 bits (1007), Expect = e-109, Method: Composition-based stats. Identities = 121/515 (23%), Positives = 217/515 (42%), Gaps = 49/515 (9%) Query: 3 SDTLSGLLENVAKKFPDRRALSVSGKFNLTHARLHDLIERAASRLVSDAGIKPGDVVALT 62 T L E + PD A+ G+ +LT+ +L++ + A L G+KP D VA+ Sbjct: 202 DKTFHQLFEQQVEMTPDHVAVVDRGQ-SLTYKQLNERANQLAHHL-RGKGVKPDDQVAIM 259 Query: 63 FPNTVEFVIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSKEGNAPAQEAAS 122 +++ ++ LAV++A P++ Y E + L+DS + +LLT+ A Sbjct: 260 LDKSLDMIVSILAVMKAGGAYVPIDPDYPGERIAYMLADSSAAILLTNALHEEKA----- 314 Query: 123 KLKISHVTATLLDAGSDLVLSVADSDSVVDSATEL--VNHPDDGALFLHTSGTTSRPKGV 180 G+ ++ V D DS ++ L VN PDD ++TSG+T KGV Sbjct: 315 -------------NGACDIIDVHDPDSYSENTNNLPHVNRPDDLVYVMYTSGSTGLAKGV 361 Query: 181 PLTQLNLASSVKNIKAVYKLTESDSTVIVLPLFHVHGLLAGLLSSLGAGAAVTLPAAGRF 240 + NL + + + + +T +D + V F G + + L AGAA+ + + R Sbjct: 362 MIEHHNLVNFCEWYRPYFGVTPADKAL-VYSSFSFDGSALDIFTHLLAGAALHIVPSERK 420 Query: 241 SATTFWPDMKKYNATWYTAVPTIHQIILDRHASHPETEYPKLRFIRSCSASLAPVILSRL 300 D + +PT + + R + + +L ++ Sbjct: 421 YDLDALNDYCNQEGITISYLPTGA------AEQFMQMDNQSFRVVITGGD-----VLKKI 469 Query: 301 EEAFGAPVLEAYAMTEATHLMSSNPLPEEGPHKPGSVGKPVGQ-EMAILNEKGEIQEPNN 359 E + Y TE T +++ + P+ +GKP+ + + IL+E +Q Sbjct: 470 ERNGTYKLYNGYGPTECTIMVTM--FEVDKPYANIPIGKPIDRTRILILDEALALQPIGV 527 Query: 360 KGEVCIRGPNVTKGYKNNPEANKAGF----EFG--WFHTGDIGYFDTDGYLHLVGRIKEL 413 GE+ I G + +GY N PE F + G + TGD F DG + +GR+ L Sbjct: 528 AGELFIVGEGLGRGYLNRPELTAEKFIVHPQTGERMYRTGDRARFLPDGNIEFLGRLDNL 587 Query: 414 INRGGEKISPIEVDAVLLTHPDVSQGVAFGVPDEKYGEE--INCAVIPREGTTVTEEDIK 471 + G +I P E++ L+ HP + ++ G + + V P E + +++ Sbjct: 588 VKIRGYRIEPGEIEPFLMNHPLIELTTVLA-KEQADGRKYLVGYYVAPEE---IPHGELR 643 Query: 472 AFCKKNLAAFKVPKRVFITDNLPKTASGKIQRRIV 506 + +L + +P P TA+GK+ RR + Sbjct: 644 EWLGNDLPDYMIPTYFVHMKAFPLTANGKVDRRAL 678 >5ES6-A nrPDB Length = 685 Score = 391 bits (1005), Expect = e-109, Method: Composition-based stats. Identities = 121/515 (23%), Positives = 217/515 (42%), Gaps = 49/515 (9%) Query: 3 SDTLSGLLENVAKKFPDRRALSVSGKFNLTHARLHDLIERAASRLVSDAGIKPGDVVALT 62 T L E + PD A+ G+ +LT+ +L++ + A L G+KP D VA+ Sbjct: 202 DKTFHQLFEQQVEMTPDHVAVVDRGQ-SLTYKQLNERANQLAHHL-RGKGVKPDDQVAIM 259 Query: 63 FPNTVEFVIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSKEGNAPAQEAAS 122 +++ ++ LAV++A P++ Y E + L+DS + +LLT+ A Sbjct: 260 LDKSLDMIVSILAVMKAGGAYVPIDPDYPGERIAYMLADSSAAILLTNALHEEKA----- 314 Query: 123 KLKISHVTATLLDAGSDLVLSVADSDSVVDSATEL--VNHPDDGALFLHTSGTTSRPKGV 180 G+ ++ V D DS ++ L VN PDD ++TSG+T KGV Sbjct: 315 -------------NGACDIIDVHDPDSYSENTNNLPHVNRPDDLVYVMYTSGSTGLAKGV 361 Query: 181 PLTQLNLASSVKNIKAVYKLTESDSTVIVLPLFHVHGLLAGLLSSLGAGAAVTLPAAGRF 240 + NL + + + + +T +D + V F G + + L AGAA+ + + R Sbjct: 362 MIEHHNLVNFCEWYRPYFGVTPADKAL-VYSSFSFDGSALDIFTHLLAGAALHIVPSERK 420 Query: 241 SATTFWPDMKKYNATWYTAVPTIHQIILDRHASHPETEYPKLRFIRSCSASLAPVILSRL 300 D + +PT + + R + + +L ++ Sbjct: 421 YDLDALNDYCNQEGITISYLPTGA------AEQFMQMDNQSFRVVITGGD-----VLKKI 469 Query: 301 EEAFGAPVLEAYAMTEATHLMSSNPLPEEGPHKPGSVGKPVGQ-EMAILNEKGEIQEPNN 359 E + Y TE T +++ + P+ +GKP+ + + IL+E +Q Sbjct: 470 ERNGTYKLYNGYGPTECTIMVTM--FEVDKPYANIPIGKPIDRTRILILDEALALQPIGV 527 Query: 360 KGEVCIRGPNVTKGYKNNPEANKAGF----EFG--WFHTGDIGYFDTDGYLHLVGRIKEL 413 GE+ I G + +GY N PE F + G + TGD F DG + +GR+ L Sbjct: 528 AGELFIVGEGLGRGYLNRPELTAEKFIVHPQTGERMYRTGDRARFLPDGNIEFLGRLDNL 587 Query: 414 INRGGEKISPIEVDAVLLTHPDVSQGVAFGVPDEKYGEE--INCAVIPREGTTVTEEDIK 471 + G +I P E++ L+ HP + ++ G + + V P E + +++ Sbjct: 588 VKIRGYRIEPGEIEPFLMNHPLIELTTVLA-KEQADGRKYLVGYYVAPEE---IPHGELR 643 Query: 472 AFCKKNLAAFKVPKRVFITDNLPKTASGKIQRRIV 506 + +L + +P P TA+GK+ RR + Sbjct: 644 EWLGNDLPDYMIPTYFVHMKAFPLTANGKVDRRAL 678 >3RG2-A nrPDB Length = 617 Score = 387 bits (993), Expect = e-108, Method: Composition-based stats. Identities = 127/520 (24%), Positives = 227/520 (43%), Gaps = 35/520 (6%) Query: 6 LSGLLENVAKKFPDRRALSVSGKFNLTHARLHDLIERAASRLVSDAGIKPGDVVALTFPN 65 L+ +L A D A+ G+ L++ L+ + A L GIKPG+ + N Sbjct: 29 LTDILTRHAA--SDSIAVI-DGERQLSYRELNQAADNLACSL-RRQGIKPGETALVQLGN 84 Query: 66 TVEFVIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSKEGNAPAQEAASKLK 125 E I F A+++ ++ E Y S + LL+ ++ + Sbjct: 85 VAELYITFFALLKLGVAPVLALFSHQRSELNAYASQIEPALLIADRQ--------HALFS 136 Query: 126 ISHVTATLLDAGSDLVLSVADSDSVVDSATELVNHP-----------DDGALFLHTSGTT 174 T + S + + +DS + + +NHP D+ A F + GTT Sbjct: 137 GDDFLNTFVTEHSSIRVVQLLNDSGEHNLQDAINHPAEDFTATPSPADEVAYFQLSGGTT 196 Query: 175 SRPKGVPLTQLNLASSVKNIKAVYKLTESDSTVIVLPLFHVHGLLA-GLLSSLGAGAAVT 233 PK +P T + SV+ + + T+ + +P H + + + G L AG V Sbjct: 197 GTPKLIPRTHNDYYYSVRRSVEICQFTQQTRYLCAIPAAHNYAMSSPGSLGVFLAGGTVV 256 Query: 234 LPAAGRFSATTFWPDMKKYNATWYTAVPTIHQIILDR-HASHPETEYPKLRFIRSCSASL 292 L A SAT +P ++K+ VP + L + L+ ++ A L Sbjct: 257 LAADP--SATLCFPLIEKHQVNVTALVPPAVSLWLQALIEGESRAQLASLKLLQVGGARL 314 Query: 293 APVILSRLEEAFGAPVLEAYAMTEATHLMSSNPLPEEGPHKPGSVGKPV--GQEMAILNE 350 + + +R+ G + + + M E L++ L + + G P+ E+ + + Sbjct: 315 SATLAARIPAEIGCQLQQVFGMAE--GLVNYTRLDDSAEKIIHTQGYPMCPDDEVWVADA 372 Query: 351 KGEIQEPNNKGEVCIRGPNVTKGYKNNPEANKAGFE-FGWFHTGDIGYFDTDGYLHLVGR 409 +G G + RGP +GY +P+ N + F+ G++ +GD+ D +GY+ + GR Sbjct: 373 EGNPLPQGEVGRLMTRGPYTFRGYYKSPQHNASAFDANGFYCSGDLISIDPEGYITVQGR 432 Query: 410 IKELINRGGEKISPIEVDAVLLTHPDVSQGVAFGVPDEKYGEEINCAVIPREGTTVTEED 469 K+ INRGGEKI+ E++ +LL HP V + DE GE+ ++ +E + Sbjct: 433 EKDQINRGGEKIAAEEIENLLLRHPAVIYAALVSMEDELMGEKSCAYLVVKE--PLRAVQ 490 Query: 470 IKAFCKKN-LAAFKVPKRVFITDNLPKTASGKIQRRIVAQ 508 ++ F ++ +A FK+P RV D+LP TA GK+ ++ + Q Sbjct: 491 VRRFLREQGIAEFKLPDRVECVDSLPLTAVGKVDKKQLRQ 530 >3DLP-X nrPDB Length = 504 Score = 381 bits (979), Expect = e-106, Method: Composition-based stats. Identities = 138/516 (26%), Positives = 225/516 (43%), Gaps = 24/516 (4%) Query: 4 DTLSGLLENVAKKFPDRRALSVSGKF-NLTHARLHDLIERAASRLVSDAGIKPGDVVALT 62 T++ +L A + PD AL+V + LTHA L +E A+RL +D G++P VA+ Sbjct: 2 QTVNEMLRRAATRAPDHCALAVPARGLRLTHAELRARVEAVAARLHAD-GLRPQQRVAVV 60 Query: 63 FPNTVEFVIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSKEGNAPAQEAAS 122 PN+ + VI LA+ R A A LN + E + + + A ++ A Sbjct: 61 APNSADVVIAILALHRLGAVPALLNPRLKSAELAELIKRGEMTAAV-----IAVGRQVAD 115 Query: 123 KLKISHVTATLLDAGSDLVLSVADSDSVVDSATELVNHPDDGALFLHTSGTTSRPKGVPL 182 + S A ++ G ++ + S + P A +TSGTT PK + Sbjct: 116 AIFQSGSGARIIFLG--DLVRDGEPYSYGPPIEDPQREPAQPAFIFYTSGTTGLPKAAII 173 Query: 183 TQLNLASSVKNIKAVYKLTESD--STVIVLPLFHVHGLLAGLLSSLGAGAAVTLPAAGRF 240 Q S V + L + ++PL+HV G A L+++L + F Sbjct: 174 PQRAAESRVLFMSTQVGLRHGRHNVVLGLMPLYHVVGFFAVLVAALALDGTYVV--VEEF 231 Query: 241 SATTFWPDMKKYNATWYTAVPTIHQIILDRHASH-PETEYPKLRFIRSCSASLAPVILSR 299 +++ T A PT + A + LR + A++ +L Sbjct: 232 RPVDALQLVQQEQVTSLFATPTHLDALAAAAAHAGSSLKLDSLRHVTFAGATMPDAVLET 291 Query: 300 LEEAFGAPVLEAYAMTEATHLMSSNPLPEEGPHKPGSVGKPVGQEMAILNEKG---EIQE 356 + + + Y TEA N L P + E+ I+ G EI Sbjct: 292 VHQHLPGEKVNIYGTTEA-----MNSLYMRQPKTGTEMAPGFFSEVRIVRIGGGVDEIVA 346 Query: 357 PNNKGE-VCIRGPNVTKGYKNNPEANKAGFEFGWFHTGDIGYFDTDGYLHLVGRIKELIN 415 +GE + + GY N P+A + GW+ T D+ + +G + ++GR+ ++I Sbjct: 347 NGEEGELIVAASDSAFVGYLNQPQATAEKLQDGWYRTSDVAVWTPEGTVRILGRVPDMII 406 Query: 416 RGGEKISPIEVDAVLLTHPDVSQGVAFGVPDEKYGEEINCAVIPREGTTVTEEDIKAFCK 475 GGE I P E++ VL T P V++ V G+ D+++G+ + V+PR G T++ + + FC+ Sbjct: 407 SGGENIHPSEIERVLGTAPGVTEVVVIGLADQRWGQSVTACVVPRLGETLSADALDTFCR 466 Query: 476 -KNLAAFKVPKRVFITDNLPKTASGKIQRRIVAQHF 510 LA FK PKR FI D LPK A K+ RR + Q Sbjct: 467 SSELADFKRPKRYFILDQLPKNALNKVLRRQLVQQV 502 >3IPL-A nrPDB Length = 501 Score = 379 bits (973), Expect = e-105, Method: Composition-based stats. Identities = 129/511 (25%), Positives = 217/511 (42%), Gaps = 34/511 (6%) Query: 10 LENVAKKFPDRRALSVSGKFNLTHARLHDLIERAASRLVSDAGIKPGDVVALTFPNTVEF 69 L A++ A++ G+ + T+ L+ A RL + V L N+++ Sbjct: 7 LYKQAQQNGHHIAIT-DGQESYTYQNLYCEASLLAKRLKAYQ----QSRVGLYIDNSIQS 61 Query: 70 VIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSKEGNAPAQEAASKLKISHV 129 +I+ A A A +N T E + D +L+ + + S I Sbjct: 62 IILIHACWLANIEIAMINTRLTPNEMTNQMRSIDVQLIFCTLPLELRGFQIVSLDDIEFA 121 Query: 130 TATL-----LDAGSDLVLSVADSDSVVDSAT----ELVNHPDDGALFLHTSGTTSRPKGV 180 + LD + ++ V + + DD A + TSGTT K V Sbjct: 122 GRDITTNGLLDNTMGIQYDTSNETVVPKESPSNILNTSFNLDDIASIMFTSGTTGPQKAV 181 Query: 181 PLTQLNLASSVKNIKAVYKLTESDSTVIVLPLFHVHGLLAGLLSSLGAGAAVTLPAAGRF 240 P T N +S K + + VLP++H+ GL + LL ++ G V + +F Sbjct: 182 PQTFRNHYASAIGCKESLGFDRDTNWLSVLPIYHISGL-SVLLRAVIEGFTVRI--VDKF 238 Query: 241 SATTFWPDMKKYNATWYTAVPTIHQIILDRHASHPETEYPKLRFIRSCSASLAPVILSRL 300 +A +K T + VP ++ + P L+ I A L+ ++ Sbjct: 239 NAEQILTMIKNERITHISLVPQTLNWLMQQGLHEP----YNLQKILLGGAKLSATMIETA 294 Query: 301 EEAFGAPVLEAYAMTEATHLMSSNPLPEEGPHKPGSVGKPVGQEMAILNEKGEIQEPNNK 360 + + P+ ++ MTE + PE +P +VG P N +I+ PN + Sbjct: 295 LQ-YNLPIYNSFGMTETCSQFLTAT-PEMLHARPDTVGMPSA------NVDVKIKNPNKE 346 Query: 361 G--EVCIRGPNVTKGYKNNPEANKAGFEFGWFHTGDIGYFDTDGYLHLVGRIKELINRGG 418 G E+ I+G NV GY P FE G+F+TGDI D +GY+ + R K+LI GG Sbjct: 347 GHGELMIKGANVMNGYLY-PTDLTGTFENGYFNTGDIAEIDHEGYVMIYDRRKDLIISGG 405 Query: 419 EKISPIEVDAVLLTHPDVSQGVAFGVPDEKYGEEINCAVIPREGTTVTEEDIKAFCKKNL 478 E I P +++ V P +S V G PD+ +G+ + + +++ + A+ K+L Sbjct: 406 ENIYPYQIETVAKQFPGISDAVCVGHPDDTWGQVPKLYFVSE--SDISKAQLIAYLSKHL 463 Query: 479 AAFKVPKRVFITDNLPKTASGKIQRRIVAQH 509 A +KVPK D LP T++GK+QR + + Sbjct: 464 AKYKVPKHFEKVDTLPYTSTGKLQRNKLYRE 494 >5U29-A nrPDB Length = 694 Score = 377 bits (968), Expect = e-105, Method: Composition-based stats. Identities = 123/544 (22%), Positives = 227/544 (41%), Gaps = 45/544 (8%) Query: 8 GLLENVAKKFPDRRALSVSGK-----FNLTHARLHDLIERAASRLVSDAGIKPGDVVALT 62 L+ K P + A+ +++ L R A+ L G+K GD V++ Sbjct: 121 NCLDRHYYKNPKKTAIIYEADEPSESREVSYEELMQETCRVANVL-KSYGVKKGDAVSIY 179 Query: 63 FPNTVEFVIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSKEGNAPAQEAAS 122 P T + FLA R A + + A ++AE ++D + K+L+T+ EG + A+ Sbjct: 180 LPMTWQAAAAFLACARIGAIHSAVFAGFSAESLRDRVNDCECKVLITTDEGRRGGKTIAT 239 Query: 123 KLKISHVTATLLDAGSDLVLSVADSDSVVDSATELVNH----------------PDDGAL 166 K + + LVL + + + +D Sbjct: 240 KQIVDAALQQCPLVENVLVLRRTGNKVPMTEGRDKWWDEECAKMPAYCPCERMASEDPLF 299 Query: 167 FLHTSGTTSRPKGVPL-TQLNLASSVKNIKAVYKLTESDSTVIVLPLFHVHGLLAGLLSS 225 L+TSG+T +PKGV T L + +K V+ D + + + G + Sbjct: 300 ILYTSGSTGKPKGVVHSTAGYLLGTALTLKYVFDAHPDDRFACMADIGWITGHSYIIYGP 359 Query: 226 LGAGAAVTL--PAAGRFSATTFWPDMKKYNATWYTAVPTIHQIILDRHASHPET-EYPKL 282 L G + + + +W + K+ AT PT +++ H + + L Sbjct: 360 LANGITTAVFESTPVYPTPSRYWDFVDKWKATQLYTAPTAIRLLRRMGEDHVKNHDLSSL 419 Query: 283 RFIRSCSASLAPVILSRLEEAFG---APVLEAYAMTEATHLMSSNPLPEEGPHKPGSVGK 339 R + S + P + G +++ Y MTE T +S PLP KPGS Sbjct: 420 RVLGSVGEPINPEAWHWYNDFAGKNQCAIVDTYWMTE-TGSISIAPLPGAISTKPGSATF 478 Query: 340 PV-GQEMAILN-EKGEIQEPNN-KGEVCIRGP--NVTKGYKNNPEANKAGF---EFGWFH 391 P G ++ I++ + G++ E N+ +G + R P ++ + + + + G+F Sbjct: 479 PFFGMDVDIIDPQTGQVLEGNDVEGVLVARRPWPSIARTVYRDHKRYLETYMKPYPGYFF 538 Query: 392 TGDIGYFDTDGYLHLVGRIKELINRGGEKISPIEVDAVLLTHPDVSQGVAFGVPDEKYGE 451 GD D DGY+ + GR+ ++IN G ++S EV++ L+ H V++ G D+ G+ Sbjct: 539 FGDGAARDYDGYMWIKGRVDDVINVSGHRLSTAEVESALILHKGVAETAVVGCADDLTGQ 598 Query: 452 EINCAVIPREGTTVTE-------EDIKAFCKKNLAAFKVPKRVFITDNLPKTASGKIQRR 504 + V + + +++ +K + F PK++++ +LPKT SGKI RR Sbjct: 599 AVYAFVTMKPEFDLKATKEADLSKELAIQVRKVIGPFAAPKKIYLVSDLPKTRSGKIMRR 658 Query: 505 IVAQ 508 ++ + Sbjct: 659 VLRK 662 >3FCE-A nrPDB Length = 512 Score = 370 bits (949), Expect = e-103, Method: Composition-based stats. Identities = 111/517 (21%), Positives = 208/517 (40%), Gaps = 37/517 (7%) Query: 10 LENVAKKFPDRRALSVSGKFNLTHARLHDLIERAASRLVSDAGIKPGDV--VALTFPNTV 67 +E A + PD+ A +T+ +L + + A + S+ P D + + Sbjct: 7 IEKWAAETPDQTAFVWRDA-KITYKQLKEDSDALAHWISSEY---PDDRSPIMVYGHMQP 62 Query: 68 EFVIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSKEGNAPAQEAASKLKIS 127 E +I FL ++A P++ + A+ + +S +KLLL +A+ + ++ Sbjct: 63 EMIINFLGCVKAGHAYIPVDLSIPADRVQRIAENSGAKLLL-----------SATAVTVT 111 Query: 128 HVTATLLDAGSDLVLSVADSDSVVDSATELVNHPDDGALFLHTSGTTSRPKGVPLTQLNL 187 + + D + + + E D+ ++TSG+T PKGV +T L Sbjct: 112 DLPVRI--VSEDNLKDIFFTHKGNTPNPEHAVKGDENFYIIYTSGSTGNPKGVQITYNCL 169 Query: 188 ASSVKNIKAVYKLTESDSTVIVLPLFHVHGLLAGLLSSLGAGAAVTLPAAGRFSATTFWP 247 S K + L + P ++ S + G + + Sbjct: 170 VSFTKWAVEDFNLQTGQVFLNQAPFSFDLSVMDIYPSLVTGGTLWAIDKDMIARPKDLFA 229 Query: 248 DMKKYNATWYTAVPTIHQIILDRHASHPETEYPKLRFIRSCSASLAPVILSRLEEAFG-A 306 +++ + +T+ P+ ++ L AS E+ P ++ C L + +L E F A Sbjct: 230 SLEQSDIQVWTSTPSFAEMCL-MEASFSESMLPNMKTFLFCGEVLPNEVARKLIERFPKA 288 Query: 307 PVLEAYAMTEATHLMSSNPLPEEGPHKPGSVGKPVGQ-----EMAILNEKGEIQEPNNKG 361 ++ Y TEAT ++ + EE + S+ PVG + I+ E G I KG Sbjct: 289 TIMNTYGPTEATVAVTGIHVTEEVLDQYKSL--PVGYCKSDCRLLIMKEDGTIAPDGEKG 346 Query: 362 EVCIRGPNVTKGYKNNPEANKAGFE----FGWFHTGDIGYFDTDGYLHLVGRIKELINRG 417 E+ I GP+V+ GY +PE + F + TGD GY +G L GR+ I Sbjct: 347 EIVIVGPSVSVGYLGSPELTEKAFTMIDGERAYKTGDAGYV-ENGLLFYNGRLDFQIKLH 405 Query: 418 GEKISPIEVDAVLLTHPDVSQGVAFGVPDEKYGEEINCAVIPREGTTVTEEDIKAFCKKN 477 G ++ E++ L V V + + + + V+P E + E + + KK Sbjct: 406 GYRMELEEIEHHLRACSYVEGAVIVPIKKGEKYDYLLAVVVPGEHSFEKEFKLTSAIKKE 465 Query: 478 LAA----FKVPKRVFITDNLPKTASGKIQRRIVAQHF 510 L + +P++ ++P T +GK+ R+ + Sbjct: 466 LNERLPNYMIPRKFMYQSSIPMTPNGKVDRKKLLSEV 502 >3E7W-A nrPDB Length = 511 Score = 364 bits (933), Expect = e-101, Method: Composition-based stats. Identities = 111/517 (21%), Positives = 203/517 (39%), Gaps = 32/517 (6%) Query: 10 LENVAKKFPDRRALSVSGKFNLTHARLHDLIERAASRLVSDAGIKPGDVVALTFPNTVEF 69 ++ A+ +P A G+ +LT+ L + +RAA+ + + + + Sbjct: 7 IQTHAETYPQTDAFRSQGQ-SLTYQELWEQSDRAAAAIQKRISGEKKSPILVYGHMEPHM 65 Query: 70 VIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSKEGNAPAQEAASKLKISHV 129 ++ FL ++A P++ + +E + S ++LL+ A+ L I V Sbjct: 66 IVSFLGSVKAGHPYIPVDLSIPSERIAKIIESSGAELLI-----------HAAGLSIDAV 114 Query: 130 TATLLDAGSDLVLSVADSDSVVDSATELVNHPDDGALFLHTSGTTSRPKGVPLTQLNLAS 189 + ++ +L D + ++TSG+T PKGV ++ NL S Sbjct: 115 GQQIQTVSAEELLENEGGSVSQDQ----WVKEHETFYIIYTSGSTGNPKGVQISAANLQS 170 Query: 190 SVKNIKAVYKLTESDSTVIVLPLFHVHGLLAGLLSSLGAGAAVTLPAAGRFSATTFWPDM 249 I A + ++ + P ++ G + + ++ Sbjct: 171 FTDWICADFPVSGGKIFLNQAPFSFDLSVMDLYPCLQSGGTLHCVTKDAVNKPKVLFEEL 230 Query: 250 KKYNATWYTAVPTIHQIILDRHASHPETEYPKLRFIRSCSASLAPVILSRLEEAFG-APV 308 KK +T+ P+ Q+ L + P C L + L E F A + Sbjct: 231 KKSGLNVWTSTPSFVQMCL-MDPGFSQDLLPHADTFMFCGEVLPVSVAKALLERFPKAKI 289 Query: 309 LEAYAMTEATHLMSS----NPLPEEGPHKPGSVGKPVGQEMAILNEKGEIQEPNNKGEVC 364 Y TEAT ++S N + P KP + I++E+G+ KGE+ Sbjct: 290 FNTYGPTEATVAVTSVEITNDVISRSESLPVGFAKP-DMNIFIMDEEGQPLPEGEKGEIV 348 Query: 365 IRGPNVTKGYKNNPEANKAGF---EFGW-FHTGDIGYFDTDGYLHLVGRIKELINRGGEK 420 I GP+V++GY PE + F E W + TGD G+ DG + GR+ I G + Sbjct: 349 IAGPSVSRGYLGEPELTEKAFFSHEGQWAYRTGDAGFI-QDGQIFCQGRLDFQIKLHGYR 407 Query: 421 ISPIEVDAVLLTHPDVSQGVAFGVPDEKYGEEINCAVIPREGTTVTEEDIKAFCKKNLA- 479 + E++ + V V E + A++P E E + + KK LA Sbjct: 408 MELEEIEFHVRQSQYVRSAVVIPYQPNGTVEYLIAAIVPEEHEFEKEFQLTSAIKKELAA 467 Query: 480 ---AFKVPKRVFITDNLPKTASGKIQRRIVAQHFLEK 513 A+ +P++ D++ TA+GKI R+ + + L + Sbjct: 468 SLPAYMIPRKFIYQDHIQMTANGKIDRKRIGEEVLVR 504 >5EY8-A nrPDB Length = 630 Score = 362 bits (930), Expect = e-100, Method: Composition-based stats. Identities = 128/612 (20%), Positives = 211/612 (34%), Gaps = 116/612 (18%) Query: 2 DSDTLSGLLENVAKKFPDRRALSVSG--------KFNLTHARLHDLIERAASRLVSDAGI 53 D ++ +E AK D+ A +LT A+ A+RL Sbjct: 17 DGSSIVAHVERWAKVRGDKLAYRFLDFSTERDGVPRDLTWAQFSARNRAVAARL--QQVT 74 Query: 54 KPGDVVALTFPNTVEFVIMFLAVIRARATAAPLNAAYTAE---EFEFYLSDSDSKLLLTS 110 +PGD VA+ P +++++ F + A A PL L + +LT+ Sbjct: 75 QPGDRVAILCPQNLDYLVAFFGALYAGRIAVPLFDPSEPGHVGRLHAVLDNCHPSAILTT 134 Query: 111 KEGNAPAQEAASKLKISHVTATLLDAGSDLVLSVADSDSVVDSATELVNHPDD-----GA 165 E ++ ++ V D+V D +PD+ A Sbjct: 135 TEAAEGVRKF------------FRTRPANQRPRVIAVDAVPDDVASTWVNPDEPDETTIA 182 Query: 166 LFLHTSGTTSRPKGVPLTQLNLASSVKNIKAVYKLTESDSTVIVLPLFHVHGLLAGLLSS 225 +TSG+T P GV +T LNLA++V + + E D + LP FH GL+ LL+ Sbjct: 183 YLQYTSGSTRIPTGVQITHLNLATNVVQVIEALEGEEGDRGLSWLPFFHDMGLITALLAP 242 Query: 226 L-GAGAAVTLPAAGRFSATTFWPDMKKYN---ATWYTAVPTIHQIILDRH----ASHPET 277 + G PAA + ++ + + P P Sbjct: 243 MIGHYFTFMTPAAFVRRPERWIRELARKEGDTGGTISVAPNFAFDHAAARGVPKPGSPPL 302 Query: 278 EYPKLRFIRSCSASLAPVILSRLEEAFG------APVLEAYAMTEATHLMSSNPLPEE-- 329 + ++ + + S ++ + R EAFG + +Y + EAT +S+ P EE Sbjct: 303 DLSNVKAVLNGSEPISAATVRRFNEAFGPFGFPPKAIKPSYGLAEATLFVSTTPSAEEPK 362 Query: 330 ----------------------GPHKPGSVGKP-VGQEMAILNEKG-EIQEPNNKGEVCI 365 S GK + + I++ + GE+ I Sbjct: 363 IITVDRDQLNSGRIVEVDADSPKAVAQASAGKVGIAEWAVIVDAESATELPDGQVGEIWI 422 Query: 366 RGPNVTKGYKNNPEANKAGFEF------------------GWFHTGDIGYFDTDGYLHLV 407 G N+ GY PE + A F+ W TGD G F DG L++ Sbjct: 423 SGQNMGTGYWGKPEESVATFQNILKSRTNPSHAEGATDDATWVRTGDYGAF-YDGDLYIT 481 Query: 408 GRIKELINRGGEKISPIEVDAVLLTHPDV---SQGVAFGVPDEKYGEEI----------- 453 GR+K+L+ G P +++ AF VP + +E+ Sbjct: 482 GRVKDLVIIDGRNHYPQDLEYSAQEASKAIRTGYVAAFSVPANQLPDEVFENAHSGIKRD 541 Query: 454 ------NCAVIPREGTTVTEEDIKAFCKKNLAAFKVPKRVFITD-------NLPKTASGK 500 ++ + DI AA V V + D +P+T+SGK Sbjct: 542 PDDTSEQLVIVAERAPGAHKLDIGPITDDIRAAIAVRHGVTVRDVLLTAAGAIPRTSSGK 601 Query: 501 IQRRIVAQHFLE 512 I RR +L+ Sbjct: 602 IGRRACRAAYLD 613 >5HM3-A nrPDB Length = 657 Score = 355 bits (912), Expect = 2e-98, Method: Composition-based stats. Identities = 127/602 (21%), Positives = 204/602 (33%), Gaps = 113/602 (18%) Query: 10 LENVAKKFPDRRALSVSG--------KFNLTHARLHDLIERAASRLVSDAGIKPGDVVAL 61 +E AK D+ A ++ + +RL +PGD VA+ Sbjct: 53 VEKWAKVRGDKLAYRFLDFSTERDGVARDILWSDFSARNRAVGARL--QQVTQPGDRVAI 110 Query: 62 TFPNTVEFVIMFLAVIRARATAAPLN---AAYTAEEFEFYLSDSDSKLLLT---SKEGNA 115 P ++++I F + + A PL L D +LT S EG Sbjct: 111 LCPQNLDYLISFFGALYSGRIAVPLFDPAEPGHVGRLHAVLDDCAPSTILTTTDSAEGVR 170 Query: 116 PAQEAASKLKISHVTATLLDAGSDLVLSVADSDSVVDSATELVNHPDDGALFLHTSGTTS 175 A S + V A D V + + A E + A +TSG+T Sbjct: 171 KFIRARSAKERPRVIAV------DAVPTEVAATWQQPEANE-----ETVAYLQYTSGSTR 219 Query: 176 RPKGVPLTQLNLASSVKNIKAVYKLTESDSTVIVLPLFHVHGLLAGLLSS-LGAGAAVTL 234 P GV +T LNL ++V + + E D V LP FH GL+ LL+S LG Sbjct: 220 IPSGVQITHLNLPTNVVQVLNALEGQEGDRGVSWLPFFHDMGLITVLLASVLGHSFTFMT 279 Query: 235 PAAGRFSATTFWPDMKKYN---ATWYTAVPTIHQIILDR----HASHPETEYPKLRFIRS 287 PAA + ++ + ++A P P + ++ I + Sbjct: 280 PAAFVRRPGRWIRELARKPGETGGTFSAAPNFAFEHAAVRGVPRDDEPPLDLSNVKGILN 339 Query: 288 CSASLAPVILSRLEEAF------GAPVLEAYAMTEATHLMSSNPLPE------------- 328 S ++P + + EAF V +Y + EAT +S+ P+ E Sbjct: 340 GSEPVSPASMRKFFEAFAPYGLKQTAVKPSYGLAEATLFVSTTPMDEVPTVIHVDRDELN 399 Query: 329 -----------EGPHKPGSVGKPVGQEMAILNEKGE--IQEPNNKGEVCIRGPNVTKGYK 375 S GK E A++ + GE+ + G N+ GY Sbjct: 400 NQRFVEVAADAPNAVAQVSAGKVGVSEWAVIVDADTASELPDGQIGEIWLHGNNLGTGYW 459 Query: 376 NNPEANKAGF------------------EFGWFHTGDIGYFDTDGYLHLVGRIKELINRG 417 E + F + W TGD G + D +L++ GRIK+L+ Sbjct: 460 GKEEESAQTFKNILKSRISESRAEGAPDDALWVRTGDYGTYFKD-HLYIAGRIKDLVIID 518 Query: 418 GEKISPIEVDAVLLTHPD---VSQGVAFGVPDEKYGEEI-----------------NCAV 457 G P +++ V AF VP + + + + Sbjct: 519 GRNHYPQDLECTAQESTKALRVGYAAAFSVPANQLPQTVFDDSHAGLKFDPEDTSEQLVI 578 Query: 458 IPREGTTVTEEDIKAFCKKNLAAFKVPKRVFITD-------NLPKTASGKIQRRIVAQHF 510 + + D + AA V V + D +P+T+SGKI RR + Sbjct: 579 VGERAAGTHKLDHQPIVDDIRAAIAVGHGVTVRDVLLVSAGTIPRTSSGKIGRRACRAAY 638 Query: 511 LE 512 L+ Sbjct: 639 LD 640 >4LGC-A nrPDB Length = 539 Score = 355 bits (911), Expect = 2e-98, Method: Composition-based stats. Identities = 125/523 (23%), Positives = 223/523 (42%), Gaps = 49/523 (9%) Query: 5 TLSGLLENVAKKFPDRRALSVSGKFN----LTHARLHDLIERAASRLVSDAGIKPGDVVA 60 T LE V++ PD A+ K +T +LH + A L+ + I PG +V Sbjct: 50 TPGKQLEYVSECKPDSTAVICLDKEQNCSVITWHQLHVYSSQLAWYLIENE-IGPGSIVL 108 Query: 61 LTFPNTVEFVIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSKEGNAPAQEA 120 FPN++E +I A+ +A A P++ + ++S+ + + NA A Sbjct: 109 TMFPNSIEHIIAVFAIWKAGACYMPMS---------YKAAESEIREACDTIHPNA----A 155 Query: 121 ASKLKISHVTATLLDAGSDLVLSVADSDSVVDSATELVNHPDDGALFLHTSGTTSRPKGV 180 ++ KI + L +D + + S + L N P+ +L + GT+ + K + Sbjct: 156 FAECKIPGLKFCL---SADEIYEAMEGRSKEMPSDRLAN-PNMISL---SGGTSGKMKFI 208 Query: 181 PLTQLNLAS-----SVKNIKAVYKLTESDSTVIVLPLFHVHGLLAGLLSSLGAGAAVTLP 235 + NL ++++ + + ++V PLFH A + L G + L Sbjct: 209 ---RQNLPCGLDDETIRSWSLMSGMGFEQRQLLVGPLFHGAPHSAA-FNGLFMGNTLVL- 263 Query: 236 AAGRFSATTFWPDMKKYNATWYTAVPTIHQIILDRHASHPETEYPKLRFIRSCSASLAPV 295 +KKY + VPT+ + E ++ L+ + +P Sbjct: 264 -TRNLCPGNILNMIKKYKIEFIQMVPTLMNRLAKLEGVGKE-DFASLKALCHTGGVCSPW 321 Query: 296 ILSRLEEAFG-APVLEAYAMTEATHLMSSNPLPEEGPHKPGSVGKPVG-QEMAILNEKGE 353 + + G + E Y+MTE L +E PGS+G+PVG +++I +E G+ Sbjct: 322 LKQIWIDLLGPEKIYEMYSMTECIGLTCIRG--DEWVKHPGSIGRPVGDSKVSIRDENGK 379 Query: 354 IQEPNNKGEVCIRGPN---VTKGYKNNPEANKAGFEFGWFHTGDIGYFDTDGYLHLVGRI 410 P GE+ + P VT+ P K G+ GDIGY D GYL+ R Sbjct: 380 EVAPFEIGEIYMTAPASYLVTEYINWEPLEVKE---GGFRSVGDIGYVDEQGYLYFSDRR 436 Query: 411 KELINRGGEKISPIEVDAVLLTHPDVSQGVAFGVPDEKYGEEINCAVIPREGTTVTEEDI 470 +++ GGE + EV+ LL + D+ V G+PDE G ++ + G + E++ Sbjct: 437 SDMLVSGGENVFATEVETALLRYKDILDAVVVGIPDEDLGRRLHAVI--ETGKEIPAEEL 494 Query: 471 KAFCKKNLAAFKVPKRVFITDNLPKTASGKIQRRIVAQHFLEK 513 K F +K L +K+PK ++ + +GK R+ + + + + Sbjct: 495 KTFLRKYLTPYKIPKTFEFVRSIRRGDNGKADRKRILEDCIAR 537 >5EY9-A nrPDB Length = 629 Score = 352 bits (904), Expect = 2e-97, Method: Composition-based stats. Identities = 123/602 (20%), Positives = 206/602 (34%), Gaps = 113/602 (18%) Query: 10 LENVAKKFPDRRALSVSG--------KFNLTHARLHDLIERAASRLVSDAGIKPGDVVAL 61 +E A+ D+ A + ++ + +RL +PGD +A+ Sbjct: 25 VEKWARVRGDKLAYRFLDFSTERDGVERDILWSEFSARNRAVGARL--QQVTQPGDRIAI 82 Query: 62 TFPNTVEFVIMFLAVIRARATAAPLN---AAYTAEEFEFYLSDSDSKLLLT---SKEGNA 115 P ++++I F + + A PL L D +LT S EG Sbjct: 83 LCPQNLDYLISFFGALYSGRIAVPLFDPAEPGHVGRLHAVLDDCTPSTILTTTDSAEGVR 142 Query: 116 PAQEAASKLKISHVTATLLDAGSDLVLSVADSDSVVDSATELVNHPDDGALFLHTSGTTS 175 + S + V A D V + S A EL A +TSG+T Sbjct: 143 KFIRSRSAKERPRVIAV------DAVPTEVASTWQQPEANELTT-----AYLQYTSGSTR 191 Query: 176 RPKGVPLTQLNLASSVKNIKAVYKLTESDSTVIVLPLFHVHGLLAGLLSS-LGAGAAVTL 234 P GV +T LNL ++V + + E D V LP FH GL+ LL+S LG Sbjct: 192 VPSGVQITHLNLPTNVLQVLNALEGQEGDRGVSWLPFFHDMGLITVLLASVLGHSFTFMT 251 Query: 235 PAAGRFSATTFWPDMKKYN---ATWYTAVPTIHQIILDR----HASHPETEYPKLRFIRS 287 PAA + ++ + ++A P P + ++ I + Sbjct: 252 PAAFVRRPGRWIRELARKPGETGGTFSAAPNFAFEHAAMRGVPRDDEPPLDLSNVKGILN 311 Query: 288 CSASLAPVILSRLEEAF------GAPVLEAYAMTEATHLMSSNPLPE------------- 328 S ++P + + +AF V +Y + EAT +S+ P+ E Sbjct: 312 GSEPVSPASMRKFFKAFEPYGLRETAVKPSYGLAEATLFVSTTPMDEVPTVIHVDRDELN 371 Query: 329 -----------EGPHKPGSVGKPVGQEMAILNEKGE--IQEPNNKGEVCIRGPNVTKGYK 375 S GK E A++ + GE+ + G N+ GY Sbjct: 372 KQRFVEVAADAPNAVAQVSAGKVGVDEWAVIVDTETASELPDGQIGEIWLHGNNLGIGYW 431 Query: 376 NNPEANKAGF------------------EFGWFHTGDIGYFDTDGYLHLVGRIKELINRG 417 E + F + W TGD G + G+L++ GRIK+L+ Sbjct: 432 GKEEESAQTFRNILKSRVPESHAEGAPDDGLWVRTGDYGTYFK-GHLYIAGRIKDLVIID 490 Query: 418 GEKISPIEVDAVLLTHPD---VSQGVAFGVPDEKYGEEI-----------------NCAV 457 G P +++ V AF VP + +++ + Sbjct: 491 GRNHYPQDLEYTAQESTKALRVGYVAAFSVPANQLPQKVFDDPHAGLSFDPEDTSEQLVI 550 Query: 458 IPREGTTVTEEDIKAFCKKNLAAFKVPKRVFITD-------NLPKTASGKIQRRIVAQHF 510 + + + + AA V V + D +P+T+SGKI RR + Sbjct: 551 VGERAAGTHKLEYQPIADDIRAAIAVGHGVTVRDVLLVSAGTIPRTSSGKIGRRACRTAY 610 Query: 511 LE 512 ++ Sbjct: 611 ID 612 >3PBK-A nrPDB Length = 583 Score = 342 bits (877), Expect = 2e-94, Method: Composition-based stats. Identities = 132/544 (24%), Positives = 206/544 (37%), Gaps = 57/544 (10%) Query: 10 LENVAKKFPDRRALSVSGKFNLTHARLHDLIERAASRLVSDAGIKPGDVVALTFPNTVEF 69 L + F DRR + L + L E A RL+S +K GD VAL + EF Sbjct: 31 LSSAGMNFYDRRC---QLEDQLEYQTLKARAEAGAKRLLS-LNLKKGDRVALIAETSSEF 86 Query: 70 VIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSKEGNAPAQEAASKLKISHV 129 V F A A A PL + DS S L PA + V Sbjct: 87 VEAFFACQYAGLVAVPLAIPMGVGQ-----RDSWSAKLQGLLASCQPAAIITGDEWLPLV 141 Query: 130 TATLLDAGSDLVLSVADSDSVVDSATELVNH-PDDGALFLHTSGTTSRPKGVPLTQLNLA 188 A D VLS A ++ ++ L P+D A +TSG+T P+GV +T + Sbjct: 142 NAATHDNPELHVLSHAWFKALPEADVALQRPVPNDIAYLQYTSGSTRFPRGVIITHREVM 201 Query: 189 SSVKNIK-AVYKLTESDSTVIVLPLFHVHGLLAGLLSSLGAGAAVTLPAAGRF--SATTF 245 ++++ I KL D V LP +H GL+ LL+ + +V F + Sbjct: 202 ANLRAISHDGIKLRPGDRCVSWLPFYHDMGLVGFLLTPVATQLSVDYLRTQDFAMRPLQW 261 Query: 246 WPDMKKYNATWYTAVPTIHQIILDRHASHPETEYPKLRFIRSCS---ASLAPVILSRLEE 302 + K T + P + R + + L R ++ L + E Sbjct: 262 LKLISKNRGTV-SVAPPFGYELCQRRVNEKDLAELDLSCWRVAGIGAEPISAEQLHQFAE 320 Query: 303 AF------GAPVLEAYAMTEATHLMSS---------NPLPEE------GPHKPGS----- 336 F + Y + E +S N + + PG+ Sbjct: 321 CFRQVNFDNKTFMPCYGLAENALAVSFSDEASGVVVNEVDRDILEYQGKAVAPGAETRAV 380 Query: 337 -----VGKPVGQE-MAILNEKGEIQEPNNKGEVCIRGPNVTKGYKNNPEANKAGFEFGWF 390 GK + + + I NE G G +CI GP++ GY + + GW Sbjct: 381 STFVNCGKALPEHGIEIRNEAGMPVAERVVGHICISGPSLMSGYFGDQVSQDEIAATGWL 440 Query: 391 HTGDIGYFDTDGYLHLVGRIKELINRGGEKISPIEVDAVLLTHPDVS--QGVAFGVPDEK 448 TGD+GY DGYL++ GRIK+LI G I P +++ + P++ +AF EK Sbjct: 441 DTGDLGYLL-DGYLYVTGRIKDLIIIRGRNIWPQDIEYIAEQEPEIHSGDAIAFVTAQEK 499 Query: 449 YGEEINCAVIPREGTTVTEEDIKAFCKKNLAAFKVPKRVFITD--NLPKTASGKIQRRIV 506 +I C + E + I A + + F V + + ++P+T+SGK R Sbjct: 500 IILQIQCRISDEERRG---QLIHALAARIQSEFGVTAAIDLLPPHSIPRTSSGKPARAEA 556 Query: 507 AQHF 510 + + Sbjct: 557 KKRY 560 >3LNV-A nrPDB Length = 590 Score = 341 bits (874), Expect = 5e-94, Method: Composition-based stats. Identities = 127/572 (22%), Positives = 228/572 (39%), Gaps = 76/572 (13%) Query: 4 DTLSGLLENVAKKFPDRRA---LSVSGKFNLTHARLHDLIERAASRLVSDAGIKPGDVVA 60 +L ++ A P++++ L+ + +T+ +L + A+ L + G KPGD V Sbjct: 11 QSLVDVVRLRALHSPNKKSCTFLNKELEETMTYEQLDQHAKAIAATLQA-EGAKPGDRVL 69 Query: 61 LTFPNTVEFVIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSKEGNAPAQEA 120 L F + + FL + A A P+ A+E L D +++ SK P Sbjct: 70 LLFAPGLPLIQAFLGCLYAGCIAVPIYP--PAQE---KLLDKAQRIVTNSK----PVIVL 120 Query: 121 ASKLKISHVTATLLDAGSDLVLSVADSDSVVDSATELVNHP-----DDGALFLHTSGTTS 175 I TA L+ + A + ++ P +D A +TSG+T Sbjct: 121 MIADHIKKFTADELNTNPKFLKIPAIALESIELNRSSSWQPTSIKSNDIAFLQYTSGSTM 180 Query: 176 RPKGVPLTQLNLASSVKNIKAVYKLTESDSTVIVLPLFHVHGLLAGLLSSLGAGAAVTLP 235 PKGV ++ NL ++ I + + + LP H GL+ +L+ + G + Sbjct: 181 HPKGVMVSHHNLLDNLNKIFTSFHMNDETIIFSWLPPHHDMGLIGCILTPIYGGIQAIMM 240 Query: 236 AAGRF--SATTFWPDMKKYNATWYTAVPTIHQIILDRHASHPETEYPKLRFIR---SCSA 290 + F + ++ + KY AT + P + + E L + + Sbjct: 241 SPFSFLQNPLSWLKHITKYKAT-ISGSPNFAYDYCVKRIREEKKEGLDLSSWVTAFNGAE 299 Query: 291 SLAPVILSRLEEAF------GAPVLEAYAMTEATHLMS---------SNPLPEE------ 329 + + +AF Y + EAT L++ + L +E Sbjct: 300 PVREETMEHFYQAFKEFGFRKEAFYPCYGLAEATLLVTGGTPGSSYKTLTLAKEQFQDHR 359 Query: 330 ---------GPHKPGSVGKPVGQEMAILN-EKGEIQEPNNKGEVCIRGPNVTKGYKNNPE 379 G +K S G P+ QE+ I++ + + + GE+ ++ +V KGY N PE Sbjct: 360 VHFADDNSPGSYKLVSSGNPI-QEVKIIDPDTLIPCDFDQVGEIWVQSNSVAKGYWNQPE 418 Query: 380 ANKAGFEFG---------WFHTGDIGYFDTDGYLHLVGRIKELINRGGEKISPIEVDAVL 430 + F + TGD+G+ + L++ GRIK+LI G+ P +++ L Sbjct: 419 ETRHAFAGKIKDDERSAIYLRTGDLGFLHEN-ELYVTGRIKDLIIIYGKNHYPQDIEFSL 477 Query: 431 L---THPDVSQGVAFGVPDE-KYGEEINCAVIPREGTTVTEE----DIKAFCKKNLAAFK 482 + H + + AF + +E +Y + C V R V ++ +I +N + Sbjct: 478 MHSPLHHVLGKCAAFVIQEEHEYKLTVMCEVKNRFMDDVAQDNLFNEIFELVYEN-HQLE 536 Query: 483 VPKRVFI-TDNLPKTASGKIQRRIVAQHFLEK 513 V V I +P T SGKI+R +H L+K Sbjct: 537 VHTIVLIPLKAMPHTTSGKIRRNFCRKHLLDK 568 >4GR5-A nrPDB Length = 570 Score = 331 bits (848), Expect = 5e-91, Method: Composition-based stats. Identities = 110/515 (21%), Positives = 194/515 (37%), Gaps = 40/515 (7%) Query: 6 LSGLLENVAKKFPDRRALSVSGKFNLTHARLHDLIERAASRLVSDAGIKPGDVVALTFPN 65 + L E A + PD AL + LT+ L++ R A RLV G+ PG +V + Sbjct: 77 VHELFEAQAARAPDAVAL-LHEADELTYGALNERANRLAHRLV-GLGVAPGTLVGVHLER 134 Query: 66 TVEFVIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSKEGNAPAQEAASKLK 125 + V+ LAV++A L+ + E L D+ + LL+TS+ Sbjct: 135 GFDMVVALLAVLKAGGGYTMLDPQFPVERLALSLEDTGAPLLVTSRP------------- 181 Query: 126 ISHVTATLLDAGSDLVLSVADSDSVVDSATELVNHPDDGALFLHTSGTTSRPKGVPLTQL 185 ++ L + V A SD+ + V P+D A + TSG+T RPKGV Sbjct: 182 ---LSGRLTGTTTLYVEDEAASDAPAGNLATGVG-PEDVACVMFTSGSTGRPKGVMSPHR 237 Query: 186 NLASSVKNIKAVYKLTESDSTVIVLPLFHVHGLLAGLLSSLGAGAAVTLPAAGRFSATTF 245 L + + + P+ L +L GA L + Sbjct: 238 ALTGTYLGQDYA-GFGPDEVFLQCSPVSWD-AFGLELFGALLFGARCVLQSGQNPDPLEI 295 Query: 246 WPDMKKYNATWYTAVPTIHQIILDRHASHPETEYPKLRFIRSCSASLA-PVILSRLEEAF 304 + ++ T ++ ++D + +R+ + + P + + Sbjct: 296 GELVARHGVTMLQLSASLFNFLVD----EVPEAFEGVRYAITGGEPASVPHVAKARRDHP 351 Query: 305 GAPVLEAYAMTEATHLMSS-NPLPEEGPHKPGSVGKPV-GQEMAILNEKGEIQEPNNKGE 362 + Y E+ + + + +G P+ G+ +L++ + GE Sbjct: 352 ALRLGNGYGPAESMGFTTHHAVVAGDLSGTALPIGVPLAGKRAYVLDDDLKPAANGALGE 411 Query: 363 VCIRGPNVTKGYKNNPEANKAGF-------EFG--WFHTGDIGYFDTDGYLHLVGRIKEL 413 + + G + GY + P F G + TGD+ DG L VGR + Sbjct: 412 LYVAGAGLAHGYVSRPALTAERFVADPFAGPGGERMYRTGDLARRRADGVLEYVGRADDQ 471 Query: 414 INRGGEKISPIEVDAVLLTHPDVSQGVAFGVPDEKYGEE--INCAVIPREGTTVTEEDIK 471 + G ++ P EV+A L+ HP V Q D + G++ + V R +++ Sbjct: 472 VKIRGFRVEPGEVEARLVGHPAVRQAAVLA-QDSRLGDKQLVAYVVAERADAPPDAAELR 530 Query: 472 AFCKKNLAAFKVPKRVFITDNLPKTASGKIQRRIV 506 + L A+ VP D LP+T +GK+ RR + Sbjct: 531 RHVAEALPAYMVPVECVPVDELPRTPNGKLDRRAL 565 >5JNF-C nrPDB Length = 587 Score = 311 bits (797), Expect = 4e-85, Method: Composition-based stats. Identities = 100/418 (23%), Positives = 175/418 (41%), Gaps = 43/418 (10%) Query: 3 SDTLSGLLENVAKKFPDRRALSVSGKFNLTHARLHDLIERAASRLVSDAGIKPGDVVALT 62 T L E + PD A+ G+ +LT+ +L++ + A L G+KP D VA+ Sbjct: 204 DKTFHQLFEQQVEMTPDHVAVVDRGQ-SLTYKQLNERANQLAHHL-RGKGVKPDDQVAIM 261 Query: 63 FPNTVEFVIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSKEGNAPAQEAAS 122 +++ ++ LAV++A P++ Y E + L+DS + +LLT+ A Sbjct: 262 LDKSLDMIVSILAVMKAGGAYVPIDPDYPGERIAYMLADSSAAILLTNALHEEKA----- 316 Query: 123 KLKISHVTATLLDAGSDLVLSVADSDSVVDSATEL--VNHPDDGALFLHTSGTTSRPKGV 180 G+ ++ V D DS ++ L VN PDD ++TSG+T KGV Sbjct: 317 -------------NGACDIIDVHDPDSYSENTNNLPHVNRPDDLVYVMYTSGSTGLAKGV 363 Query: 181 PLTQLNLASSVKNIKAVYKLTESDSTVIVLPLFHVHGLLAGLLSSLGAGAAVTLPAAGRF 240 + NL + + + + +T +D + V F G + + L AGAA+ + + R Sbjct: 364 MIEHHNLVNFCEWYRPYFGVTPADKAL-VYSSFSFDGSALDIFTHLLAGAALHIVPSERK 422 Query: 241 SATTFWPDMKKYNATWYTAVPTIHQIILDRHASHPETEYPKLRFIRSCSASLAPVILSRL 300 D + +PT + + R + + +L ++ Sbjct: 423 YDLDALNDYCNQEGITISYLPTGA------AEQFMQMDNQSFRVVITGGD-----VLKKI 471 Query: 301 EEAFGAPVLEAYAMTEATHLMSSNPLPEEGPHKPGSVGKPVGQ-EMAILNEKGEIQEPNN 359 E + Y TE T +++ + P+ +GKP+ + + IL+E +Q Sbjct: 472 ERNGTYKLYNGYGPTECTIMVTM--FEVDKPYANIPIGKPIDRTRILILDEALALQPIGV 529 Query: 360 KGEVCIRGPNVTKGYKNNPEANKAGF----EFG--WFHTGDIGYFDTDGYLHLVGRIK 411 GE+ I G + +GY N PE F + G + TGD F DG + +GR+ Sbjct: 530 AGELFIVGEGLGRGYLNRPELTAEKFIVHPQTGERMYRTGDRARFLPDGNIEFLGRLD 587 >3L8C-A nrPDB Length = 521 Score = 310 bits (794), Expect = 9e-85, Method: Composition-based stats. Identities = 109/531 (20%), Positives = 200/531 (37%), Gaps = 36/531 (6%) Query: 1 MDSDTLSGLLENVAKKFPDRRALSVSGKFNLTHARLHDLIERAASRLVSDAGIKPGDVVA 60 M + +E A+ D G+ T+ +L + A+ + S A + V Sbjct: 1 MSLKDMIDSIEQFAQTQADFPVYDCLGERR-TYGQLKRDSDSIAAFIDSLALLAK-SPVL 58 Query: 61 LTFPNTVEFVIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSKEGNAPAQEA 120 + T + + F+A+ ++ P++ E + + L++ +E + Sbjct: 59 VFGAQTYDMLATFVALTKSGHAYIPVDVHSAPERILAIIEIAKPSLIIAIEEFPLTIEG- 117 Query: 121 ASKLKISHVTATLLDAGSDLVLSVADSDSVVDSATELVNHPDDGALFLHTSGTTSRPKGV 180 IS V+ + +++ + + SV DD + TSGTT +PKGV Sbjct: 118 -----ISLVSLSEIESAKLAEMPYERTHSVKG---------DDNYYIIFTSGTTGQPKGV 163 Query: 181 PLTQLNLASSVKNIKA--VYKLTESDSTVIVLPLFHVHGLLAGLLSSLGAGAAVTLPAAG 238 ++ NL S + + + + + P ++ + G LP Sbjct: 164 QISHDNLLSFTNWMIEDAAFDVPKQPQMLAQPPYSFDLSVMYWAPTLALGGTLFALPKEL 223 Query: 239 RFSATTFWPDMKKYNATWYTAVPTIHQIILDRHASHPETEYPKLRFIRSCSASLAPVILS 298 + + + +T+ P+ + + + + P L L Sbjct: 224 VADFKQLFTTIAQLPVGIWTSTPSFADMAM-LSDDFCQAKMPALTHFYFDGEELTVSTAR 282 Query: 299 RLEEAFG-APVLEAYAMTEATHLMSSNPLPEEGPHKPG--SVGKPV-GQEMAILNEKGEI 354 +L E F A ++ AY TEAT +S+ + E +G P I++E G+ Sbjct: 283 KLFERFPSAKIINAYGPTEATVALSAIEITREMVDNYTRLPIGYPKPDSPTYIIDEDGKE 342 Query: 355 QEPNNKGEVCIRGPNVTKGYKNNPEANKAGF----EFGWFHTGDIGYFDTDGYLHLVGRI 410 +GE+ + GP V+KGY NNPE F +HTGDIG D L GR+ Sbjct: 343 LSSGEQGEIIVTGPAVSKGYLNNPEKTAEAFFTFKGQPAYHTGDIGSLTEDNILLYGGRL 402 Query: 411 KELINRGGEKISPIEVDAVLLTHPDVSQGVAFGV-PDEKYGEEINCAVIPREGTT----- 464 I G +I +V L P V+ VA E + + ++ ++G Sbjct: 403 DFQIKYAGYRIELEDVSQQLNQSPMVASAVAVPRYNKEHKVQNLLAYIVVKDGVKERFDR 462 Query: 465 --VTEEDIKAFCKKNLAAFKVPKRVFITDNLPKTASGKIQRRIVAQHFLEK 513 + IKA K ++ ++ +P + D+LP T +GKI + + + Sbjct: 463 ELELTKAIKASVKDHMMSYMMPSKFLYRDSLPLTPNGKIDIKTLINEVNNR 513 >5D6N-A nrPDB Length = 508 Score = 291 bits (744), Expect = 6e-79, Method: Composition-based stats. Identities = 103/483 (21%), Positives = 169/483 (34%), Gaps = 89/483 (18%) Query: 2 DSDTLSGLLENVAKKFPDRRALSVSG--------KFNLTHARLHDLIERAASRLVSDAGI 53 D ++ +E AK D+ A +LT A+ A+RL Sbjct: 41 DGSSIVAHVERWAKVRGDKLAYRFLDFSTERDGVPRDLTWAQFSARNRAVAARL--QQVT 98 Query: 54 KPGDVVALTFPNTVEFVIMFLAVIRARATAAPLNAAYTAE---EFEFYLSDSDSKLLLTS 110 +PGD VA+ P +++++ F + A A PL L + +LT+ Sbjct: 99 QPGDRVAILCPQNLDYLVAFFGALYAGRIAVPLFDPSEPGHVGRLHAVLDNCHPSAILTT 158 Query: 111 KEGNAPAQEAASKLKISHVTATLLDAGSDLVLSVADSDSVVDSATELVNHPDD-----GA 165 E ++ ++ V D+V D +PD+ A Sbjct: 159 TEAAEGVRKF------------FRTRPANQRPRVIAVDAVPDDVASTWVNPDEPDETTIA 206 Query: 166 LFLHTSGTTSRPKGVPLTQLNLASSVKNIKAVYKLTESDSTVIVLPLFHVHGLLAGLLSS 225 +TSG+T P GV +T LNLA++V + + E D + LP FH GL+ LL+ Sbjct: 207 YLQYTSGSTRIPTGVQITHLNLATNVVQVIEALEGEEGDRGLSWLPFFHDMGLITALLAP 266 Query: 226 L-GAGAAVTLPAAGRFSATTFWPDMKKYN---ATWYTAVPTIHQIILDRH----ASHPET 277 + G PAA + ++ + + P P Sbjct: 267 MIGHYFTFMTPAAFVRRPERWIRELARKEGDTGGTISVAPNFAFDHAAARGVPKPGSPPL 326 Query: 278 EYPKLRFIRSCSASLAPVILSRLEEAFG------APVLEAYAMTEATHLMSSNPLPEE-- 329 + ++ + + S ++ + R EAFG + +Y + EAT +S+ P EE Sbjct: 327 DLSNVKAVLNGSEPISAATVRRFNEAFGPFGFPPKAIKPSYGLAEATLFVSTTPSAEEPK 386 Query: 330 ----------------------GPHKPGSVGKP-VGQEMAILNEKG-EIQEPNNKGEVCI 365 S GK + + I++ + GE+ I Sbjct: 387 IITVDRDQLNSGRIVEVDADSPKAVAQASAGKVGIAEWAVIVDAESATELPDGQVGEIWI 446 Query: 366 RGPNVTKGYKNNPEANKAGFEF------------------GWFHTGDIGYFDTDGYLHLV 407 G N+ GY PE + A F+ W TGD G F DG L++ Sbjct: 447 SGQNMGTGYWGKPEESVATFQNILKSRTNPSHAEGATDDATWVRTGDYGAF-YDGDLYIT 505 Query: 408 GRI 410 GR+ Sbjct: 506 GRV 508 >5WMM-A nrPDB Length = 926 Score = 289 bits (740), Expect = 2e-78, Method: Composition-based stats. Identities = 100/490 (20%), Positives = 174/490 (35%), Gaps = 52/490 (10%) Query: 5 TLSGLLENVAKKFPDRRALSV-SGKFNLTHARLHDLIERAASRLVSDAGIKPGDVVALTF 63 T+ V + P+ AL G+ + T+ L R A L + G+ VAL Sbjct: 55 TIPERFAAVVAEQPEAVALVAADGEESWTYGELDRWANRIAHHLHAR-GVGRQHRVALVM 113 Query: 64 PNTVEFVIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSKEGNAPAQEAASK 123 + V L ++A A P+ + + L+D D L++ Sbjct: 114 ERSPLLVAAVLGTLKAGACYVPVEPTWPRARIDLVLADLDPALVI--------------- 158 Query: 124 LKISHVTATLLDAGSDLVLSVADSDSVVDSATELVN-HPDDGALFLHTSGTTSRPKGVPL 182 D L+ D + + + A ++TSG+T PKGV + Sbjct: 159 ---------------DERLAEEDLTGYPTRPLDTADVGGEHLAYLMYTSGSTGTPKGVEV 203 Query: 183 TQLNLASSVKNIKAVYKLTESDSTVIVLPLFHVHGLLAGLLSSLGAGAAVTLPAAGRFSA 242 + N+ S + + + ++ P + L GAAV P G+ A Sbjct: 204 SHRNVLSLA--LDPCWADADHQRVLVHAPPTFDASTYEMWVPLLHGGAAVVAPP-GKLDA 260 Query: 243 TTFWPDMKKYNATWYTAVPTIHQIILDRHASHPETEYPKLRFIRSCSASLAPVILSRLEE 302 + + T + D H + ++R + + L+P + RL Sbjct: 261 ARLATLIAERGVTALWLP----AGLFDLITQHHPKSFVQVREVWAGGDVLSPAAVRRLVR 316 Query: 303 AFG-APVLEAYAMTEATHLMSSNPLPEEGPHK-PGSVGKPV-GQEMAILNEKGEIQEPNN 359 G V+ Y TE T + + K P +G+P+ G + L+++ Sbjct: 317 DDGTLTVVNGYGPTETTTFAARYRMSAPARCKDPLPIGEPMAGSRLYALDDRLRQVPQGV 376 Query: 360 KGEVCIRGPNVTKGYKNNPEANKAGF--------EFGWFHTGDIGYFDTDGYLHLVGRIK 411 GE+ + G V +GY N+P F + TGD+ ++ DG L +GR+ Sbjct: 377 IGELYVGGDGVARGYANHPPLTSERFVADPFGRPGERMYRTGDLVRWNHDGQLEFLGRVD 436 Query: 412 ELINRGGEKISPIEVDAVLLTHPDVSQGVAFGVPDEKYGEEINCAVIPREGTTVTEEDIK 471 E + G ++ P E+ A L V+Q V D + V+P +ED Sbjct: 437 EQVKIRGFRVEPGEIRAALRKRDGVAQAVVVPRTDRLGERRLVAYVVPEVPAG-ADEDST 495 Query: 472 AFCKKNLAAF 481 +K A + Sbjct: 496 EHVEKWRAIY 505 Score = 34.3 bits (77), Expect = 0.12, Method: Composition-based stats. Identities = 18/88 (20%), Positives = 32/88 (36%), Gaps = 11/88 (12%) Query: 432 THPDVSQGVAFGVPDEKYGEEINCAVIPREGTTVT-------EEDIKAFCKKNLAA---- 480 P + V V + + V PR V + ++ ++ LAA Sbjct: 837 EAPGWFEAVIIPVDSGHCRDGVYRPVGPRPRQLVNLPAAARRVSRLPSWLREELAAELPE 896 Query: 481 FKVPKRVFITDNLPKTASGKIQRRIVAQ 508 VP + + + LP T +GKI + + Sbjct: 897 HLVPGDIVVMERLPLTTNGKIDHSRLPE 924 >4R0M-B nrPDB Length = 643 Score = 270 bits (690), Expect = 1e-72, Method: Composition-based stats. Identities = 121/542 (22%), Positives = 208/542 (38%), Gaps = 52/542 (9%) Query: 5 TLSGLLENVAKKFPDRRALSVSGKFNL--THARLHDLIERAASRLVSDAGIKPGDVVALT 62 TLS +LE K + ++ L+ + L GIK G V L Sbjct: 18 TLSEVLETATKHNNHGITYIRNDATEYFQSYQDLYQDALVILNGL-EQKGIKLGHKVILQ 76 Query: 63 FPNTVEFVIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLL-----LTSKEGNAPA 117 +F+ A PL A + + L +S K L + Sbjct: 77 IAKNQDFIPALWACFLGGIIPVPLTVAPS-----YDLENSAVKKLENVWKILDNPLILSD 131 Query: 118 QEAASKLKISHVTATLLDAGSDLVLSVADSDSVVDSATELVNHPDDGALFLHTSGTTSRP 177 E ++++ + L V + + S ++ + P D AL L TSG+T P Sbjct: 132 SELITEIEKLGTYSHLEGWQVISVNELRKAPSKIEQL--PILDPQDAALLLFTSGSTGMP 189 Query: 178 KGVPLTQLNLASSVKNIKAVYKLTESDSTVIVLPLFHVHGL-LAGLLSSLGAGAAVTLPA 236 KGV LT N+ S + T+ + T+ +PL HV + G+++ A + +P Sbjct: 190 KGVILTHHNILSMTAGTVVMNHFTQQEVTLNWMPLDHVGAIVFLGIMAVDLACDQIHVPM 249 Query: 237 AGRFS-ATTFWPDMKKYNATWYTAVPTIHQIILDRHAS---HPETEYPKLRFIRSCSASL 292 + ++K+ + P ++++ A H ++F+ + + Sbjct: 250 ELVLRQPLQWLELIQKHQV-SISWSPNFAFSLINQQAEELKHVSYNLSSMKFLVNAGEQV 308 Query: 293 APVILSRLEEAFGA------PVLEAYAMTEATHLMS------SNPLPEEGPHKPGSVGKP 340 + + E + A+ MTE+ ++ N L EE S+GKP Sbjct: 309 SVKTIRLFLEILEKHQLQERAIKPAFGMTESCSGITWSAGLSKNELTEENSFV--SLGKP 366 Query: 341 V-GQEMAILNEKGEIQEPNNKGEVCIRGPNVTKGYKNNPEANKAGFEFGWFHTGDIGYFD 399 + G + I++++ G + I+G +VTKGY NN E N+ F+ GWF TGD+GY Sbjct: 367 IPGATIRIVDQENNPLPEREIGRLQIQGNSVTKGYYNNNELNQEVFQEGWFTTGDLGYLS 426 Query: 400 TDGYLHLVGRIKELINRGG--EKISPIEVDAVLLTHPDVSQGVAFGVPDEKYGEEINCAV 457 G L + GR K+ I G +E L VS AF V D+ E + Sbjct: 427 K-GELFITGREKQEIIINGVNYFAHELETTIEELEGVKVSYTAAFAVFDQSR-ETDLLII 484 Query: 458 IPREGTTVTEE------DIKAFCKKNLA---AFKVPKRVFITDNLPKTASGKIQRRIVAQ 508 + E+ I++ + A+ +P + PKT+ GK+Q+ + + Sbjct: 485 TFSPESEQFEQGIKVVRKIRSHVTQKFGIAPAYVIPLERNLV---PKTSIGKVQKSKLKK 541 Query: 509 HF 510 F Sbjct: 542 DF 543 >6NJ0-A nrPDB Length = 451 Score = 261 bits (667), Expect = 5e-70, Method: Composition-based stats. Identities = 108/493 (21%), Positives = 188/493 (38%), Gaps = 65/493 (13%) Query: 18 PDRRALSVSGKFNLTHARLHDLIERAASRLVSDAGIKPGDVVALTFPNTVEFVIMFLAVI 77 + AL ++ + L L ++ AS + G+ G V L NT + ++ +LA++ Sbjct: 16 GETIALRLNDE-QLNWRELCARVDELASGF-AVQGVVEGSGVMLRAWNTPQTLLAWLALL 73 Query: 78 RARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSKEGNAPAQEAASKLKISHVTATLLDAG 137 + A P+N ++ A + D Sbjct: 74 QCGARVLPVN------------------------PQLPQPLLEELLPNLTLQFALVPDGE 109 Query: 138 SDLVLSVADSDSVVDSATELVNHPDDGALFLHTSGTTSRPKGVPLTQLNLASSVKNIKAV 197 + + +V+ A P TSG+T PK T +S + + ++ Sbjct: 110 NTFPALTSLHIQLVEGAHAATWQPTRLCSMTLTSGSTGLPKAAVHTYQAHLASAQGVLSL 169 Query: 198 YKLTESDSTVIVLPLFHVHGLLAGLLSSLGAGAAVTLPAAGRFSATTFWPDMKKYNATWY 257 + D ++ LPLFHV G + L AGA +T+ T Sbjct: 170 IPFGDHDDWLLSLPLFHVSG-QGIMWRWLYAGARMTVRDKQPLEQMLA-------GCTHA 221 Query: 258 TAVPT-IHQIILDRHASHPETEYPKLRFIRSCSASLAPVILSRLEEAFGAPVLEAYAMTE 316 + VPT + +++++R + L+ + A++ + + G Y +TE Sbjct: 222 SLVPTQLWRLLVNRSS-------VSLKAVLLGGAAIPVELTEQ-AREQGIRCFCGYGLTE 273 Query: 317 ATHLMSSNPLPEEGPHKPGSVGKPV-GQEMAILNEKGEIQEPNNKGEVCIRGPNVTKGYK 375 +S +E VG P+ G+E+ I+N EV +R ++ +GY Sbjct: 274 ----FASTVCAKEA-DGLADVGSPLPGREVKIVNN-----------EVWLRAASMAEGYW 317 Query: 376 NNPEANKAGFEFGWFHTGDIGYFDTDGYLHLVGRIKELINRGGEKISPIEVDAVLLTHPD 435 N + + GW+ T D G +G L +VGR+ L GGE I P EV+ V+ HP Sbjct: 318 RNGQLVSLVNDEGWYATRDRGEMH-NGKLTIVGRLDNLFFSGGEGIQPEEVERVIAAHPA 376 Query: 436 VSQGVAFGVPDEKYGEEINCAVIPREGTTVTEEDIKAFCKKNLAAFKVPKRVFITDNLPK 495 V Q V D+++G V+ + +V D+ + K LA F+ P R K Sbjct: 377 VLQVFIVPVADKEFGHRPVA-VMEYDHESV---DLSEWVKDKLARFQQPVRWLTLPPELK 432 Query: 496 TASGKIQRRIVAQ 508 KI R+ + + Sbjct: 433 NGGIKISRQALKE 445 >3E53-A nrPDB Length = 480 Score = 241 bits (616), Expect = 4e-64, Method: Composition-based stats. Identities = 99/472 (20%), Positives = 173/472 (36%), Gaps = 75/472 (15%) Query: 1 MDSDTLSGLLENVAKKFPDRRALSVSGKFN--------LTHARLHDLIERAASRLVSDAG 52 M +L L A+ P A + LT ++L+ A L S G Sbjct: 21 MSVRSLPAALRACARLQPHDPAFTFMDYEQDWDGVAITLTWSQLYRRTLNVAQEL-SRCG 79 Query: 53 IKPGDVVALTFPNTVEFVIMFLAVIRARATAAPLNAA---YTAEEFEFYLSDSDSKLLLT 109 GD V ++ P +E+V+ FL ++A A PL+ T E + LSDS +LT Sbjct: 80 -STGDRVVISAPQGLEYVVAFLGALQAGRIAVPLSVPQGGVTDERSDSVLSDSSPVAILT 138 Query: 110 SKEGNAPAQEAASKLKISHVTATLLDAGSDLV-LSVADSDSVVDSATELVNHPDDGALFL 168 + +A + HV ++ ++ + + D D+ + +P A Sbjct: 139 T--------SSAVDDVVQHVARRPGESPPSIIEVDLLDLDAPNGYTFKEDEYPST-AYLQ 189 Query: 169 HTSGTTSRPKGVPLTQLNLASSVKNIKAVYKLT------ESDSTVIVLPLFHVHGLLAGL 222 +TSG+T P GV ++ N+ + + + + Y + + V LP +H GL+ G+ Sbjct: 190 YTSGSTRTPAGVVMSHQNVRVNFEQLMSGYFADTDGIPPPNSALVSWLPFYHDMGLVIGI 249 Query: 223 LSS-LGAGAAVTLPAAGRFSATTFWPDMKKYNATWYTAVPTIHQIILDRHASHPET---E 278 + LG AV W + + ++A P + R + + + Sbjct: 250 CAPILGGYPAVLTSPVSFLQRPARWMHLMASDFHAFSAAPNFAFELAARRTTDDDMAGRD 309 Query: 279 YPKLRFIRSCSASLAPVILSRLEEAFGAP------VLEAYAMTEATHLMSS--------- 323 + I S S + + R + F + +Y + EAT +++ Sbjct: 310 LGNILTILSGSERVQAATIKRFADRFARFNLQERVIRPSYGLAEATVYVATSKPGQPPET 369 Query: 324 ----NPLPEEGPHKPGSVGK---------PVGQEMAILNEKGEI-QEPNNKGEVCIRGPN 369 G KP + G P + I++ I GE+ + G N Sbjct: 370 VDFDTESLSAGHAKPCAGGGATSLISYMLPRSPIVRIVDSDTCIECPDGTVGEIWVHGDN 429 Query: 370 VTKGYKNNPEANKAGF------------EFGWFHTGDIGYFDTDGYLHLVGR 409 V GY P+ ++ F E W TGD G+ DG + ++GR Sbjct: 430 VANGYWQKPDESERTFGGKIVTPSPGTPEGPWLRTGDSGFVT-DGKMFIIGR 480 >4GR4-A nrPDB Length = 469 Score = 237 bits (605), Expect = 8e-63, Method: Composition-based stats. Identities = 84/418 (20%), Positives = 149/418 (35%), Gaps = 37/418 (8%) Query: 6 LSGLLENVAKKFPDRRALSVSGKFNLTHARLHDLIERAASRLVSDAGIKPGDVVALTFPN 65 + L E A + PD AL + LT+ L++ R A RLV G+ PG +V + Sbjct: 77 VHELFEAQAARAPDAVAL-LHEADELTYGALNERANRLAHRLV-GLGVAPGTLVGVHLER 134 Query: 66 TVEFVIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSKEGNAPAQEAASKLK 125 + V+ LAV++A L+ + E L D+ + LL+TS+ Sbjct: 135 GFDMVVALLAVLKAGGGYTMLDPQFPVERLALSLEDTGAPLLVTSRP------------- 181 Query: 126 ISHVTATLLDAGSDLVLSVADSDSVVDSATELVNHPDDGALFLHTSGTTSRPKGVPLTQL 185 ++ L + V A SD+ + V P+D A + TSG+T RPKGV Sbjct: 182 ---LSGRLTGTTTLYVEDEAASDAPAGNLATGVG-PEDVACVMFTSGSTGRPKGVMSPHR 237 Query: 186 NLASSVKNIKAVYKLTESDSTVIVLPLFHVHGLLAGLLSSLGAGAAVTLPAAGRFSATTF 245 L + + + P+ L +L GA L + Sbjct: 238 ALTGTYLGQDYA-GFGPDEVFLQCSPVSWD-AFGLELFGALLFGARCVLQSGQNPDPLEI 295 Query: 246 WPDMKKYNATWYTAVPTIHQIILDRHASHPETEYPKLRFIRSCSASLA-PVILSRLEEAF 304 + ++ T ++ ++D + +R+ + + P + + Sbjct: 296 GELVARHGVTMLQLSASLFNFLVD----EVPEAFEGVRYAITGGEPASVPHVAKARRDHP 351 Query: 305 GAPVLEAYAMTEATHLMS-SNPLPEEGPHKPGSVGKPV-GQEMAILNEKGEIQEPNNKGE 362 + Y E+ + + + +G P+ G+ +L++ + GE Sbjct: 352 ALRLGNGYGPAESMGFTTHHAVVAGDLSGTALPIGVPLAGKRAYVLDDDLKPAANGALGE 411 Query: 363 VCIRGPNVTKGYKNNPEANKAGF-------EFG--WFHTGDIGYFDTDGYLHLVGRIK 411 + + G + GY + P F G + TGD+ DG L VGR Sbjct: 412 LYVAGAGLAHGYVSRPALTAERFVADPFAGPGGERMYRTGDLARRRADGVLEYVGRAD 469 >4WD1-A nrPDB Length = 658 Score = 177 bits (449), Expect = 9e-45, Method: Composition-based stats. Identities = 92/524 (17%), Positives = 178/524 (33%), Gaps = 40/524 (7%) Query: 12 NVAKKFPDRRALSVSGKFN----LTHARLHDLIERAASRLVSDAGIKPGDVVALTFPNTV 67 A PD AL + + +T A L + A+ L + G++PGD V+ PN Sbjct: 99 RAAGTRPDEPALLYVDETHEPAPVTWAELRRQVASLAAELRA-LGVRPGDRVSGYLPNIP 157 Query: 68 EFVIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSKEGNAPAQEAASKLKIS 127 + V+ LA + A + +L T +E + ++ Sbjct: 158 QAVVALLATAAVGGVWTSCAPDFGARSVLDRFQQVEPVVLFTVDGYRYGGKEHDRRDTVA 217 Query: 128 H------------VTATLLDAGSDLVLSVADSDSVVDSATELVNHPDDGALFLHTSGTTS 175 L D L + D L++SGTT Sbjct: 218 ELRRELPTLRAVIHIPLLGTEAPDGTLDWETLTAADAEPVYEQVPFDHPLWVLYSSGTTG 277 Query: 176 RPKGVPLTQLN-LASSVKNIKAVYKLTESDSTVIVLPLFHVHGLLAGLLSSLGAGAAVTL 234 PK + +Q L +K + L D + L+S L G + L Sbjct: 278 LPKAIVQSQGGILVEHLKQLGLHCDLGPGDRFFWYTSTGW--MMWNFLVSGLLTGTTIVL 335 Query: 235 -PAAGRFSATTFWPDMKKYNATWYTAVPTIHQIILDRHASHP--ETEYPKLRFIRSCSAS 291 + F AT + + + + + HP + + ++ + + + Sbjct: 336 YDGSPGFPATDAQWRIAERTGATLFGTSAAYVMACRKAGVHPARDLDLSAIQCVATTGSP 395 Query: 292 LAPVILSRLEEAFGAPVLEAYAMTEATHLMSSNPLPEEGPHKPGSVG----KPVGQEMAI 347 L P L + F A + + + + + P P +G +G ++ Sbjct: 396 LPPDGFRWLHDEFAAGGADLWIASVSGGTDVCSCFAGAVPTLPVHIGELQAPGLGTDLQS 455 Query: 348 LNEKGEIQEPNNKGEVCIRG--PNVTKGYKNNPEANK------AGFEFGWFHTGDIGYFD 399 + G+ + GE+ + P++ + N+P+ ++ + W H GD Sbjct: 456 WDPSGDPLT-DEVGELVVTNPMPSMPIRFWNDPDGSRYHDSYFDTYPGVWRH-GDWITLT 513 Query: 400 TDGYLHLVGRIKELINRGGEKISPIEVDAVLLTHPDVSQGVAFGVPDEKYGEEINCAVIP 459 + G + + GR +NR G ++ ++ + P++ + + G+ G + V Sbjct: 514 SRGSVVIHGRSDSTLNRQGVRMGSADIYEAVERLPEIRESLVIGIEQPDGGYWMPLFVHL 573 Query: 460 REGTTVTE---EDIKAFCKKNLAAFKVPKRVFITDNLPKTASGK 500 G T+ + + IK + NL+ VP V +P T +GK Sbjct: 574 APGATLDDALLDRIKRTIRVNLSPRHVPDEVIEVPGIPHTLTGK 617 >4RVO-A nrPDB Length = 436 Score = 111 bits (277), Expect = 8e-25, Method: Composition-based stats. Identities = 60/434 (13%), Positives = 133/434 (30%), Gaps = 53/434 (12%) Query: 92 AEEFEFYLSDSDSKLLLTSKEGNAPAQEAASKLKISHVTATLLDAGSDLVLSV-ADSDSV 150 + E L K + + +E SK I+ + LD + + +D + Sbjct: 15 SREKLQELQLQRLKKTINIAANSPYYKEVFSKNGITGDSIQSLDDIRKIPFTTKSDMRAN 74 Query: 151 VDSATELVNHPDDGALFLHTSGTTSRPKGVPLTQLNLAS---SVKNIKAVYKLTESDSTV 207 + DG +SGTT P + +Q +L S V + + ++D Sbjct: 75 YPFGLVAGDMKRDGVRIHSSSGTTGNPTVIVHSQHDLDSWANLVARCLYMVGIRKTDVFQ 134 Query: 208 IVLPLFHVHGLLAGLLSSLGAGAAVTLPAAGRFSATTFWPDMKKYNATWYTAVPTIHQII 267 G L + G A ++ + + T A+P+ + Sbjct: 135 NSSGYGMFTGGLGFQYGAERLGCLTV--PAAAGNSKRQIKFISDFKTTALHAIPSYAIRL 192 Query: 268 LDRHASHP-ETEYPKLRFIRSCSASLAPVILSRLEEAFGAPVLEAYAMTEATHLMSSNPL 326 + + L+ + + ++E ++ MTE + Sbjct: 193 AEVFQEEGIDPRETTLKTLVIGAEPHTDEQRRKIERMLNVKAYNSFGMTEMNGPGVAFEC 252 Query: 327 PEEGPHKPGSVGKPVGQE---MAILN-EKGEIQEPNNKGEVCIRGPNVTKGYKNNPEANK 382 E+ G ++ + I++ E GE GE+ + ++ Sbjct: 253 QEQN-------GMHFWEDCYLVEIIDPETGEPVPEGEIGELVLT------------TLDR 293 Query: 383 AGFEFGWFHTGDIGYFDT------DGYLHL---VGRIKELINRGGEKISPIEVDAVLLTH 433 + T D+ +L + GR ++ G I P++V+ +L+ Sbjct: 294 EMMPLIRYRTRDLTRILPGKCPCGRTHLRIDRIKGRSDDMFIIKGVNIFPMQVEKILVQF 353 Query: 434 PDVSQGVAFGVPDEKYGEEINCAVIPREGTTVTEEDIKAFCKKNLAAF-KVPKRVF--IT 490 P++ I + + + E ++ N K+ + + + Sbjct: 354 PELGS-----------NYLITLETVNNQDEMIVEVELSDLSTDNYIELEKIRRDIIRQLK 402 Query: 491 DNLPKTASGKIQRR 504 D + T K+ ++ Sbjct: 403 DEILVTPKVKLVKK 416 >2Y4O-A nrPDB Length = 443 Score = 89.0 bits (219), Expect = 4e-18, Method: Composition-based stats. Identities = 56/378 (14%), Positives = 125/378 (33%), Gaps = 50/378 (13%) Query: 158 VNHPDDGALFLHTSGTTSRPKGVPLTQLNLAS----SVKNIKAVYKLTESDSTVIVLPLF 213 + +SGTT +P V T ++ + + ++I+A D+ Sbjct: 88 AVPREQVVRVHASSGTTGKPTVVGYTARDIDTWANVTARSIRAA-GGRPGDTLHNA---- 142 Query: 214 HVHGLLAGLLSSLGAGA---AVTLPAAGRFSATTFWPDMKKYNATWYTAVPTIHQIILD- 269 +GL G L + GA + ++ + P+ ++D Sbjct: 143 FGYGLFTGGLG-IHYGAERLGCMVVPMSGGQTEKQVQLIRDFEPKIILVTPSYMLNLIDE 201 Query: 270 RHASHPETEYPKLRFIRSCSASLAPVILSRLEEAFGAPVLEAYAMTEATHLMSSNPLPEE 329 + L+ + + + +E G L+ Y ++E + E Sbjct: 202 MVRQGMDPAESSLKIGIFGAEPWTQALRNEVETRVGIDALDIYGLSEVMGPGVACECVET 261 Query: 330 GPHKPGSVGKPVGQE---MAILNE-KGEIQEPNNKGEVCIRGPNVTKGYKNNPEANKAGF 385 G + ++ I++ GE+ ++GE+ K Sbjct: 262 KD------GPVIWEDHFYPEIIDPVTGEVLPDGSQGELVFTS------------LTKEAM 303 Query: 386 EFGWFHTGDIGYFDT------DGYLHLVGRIKELINRGGEKISPIEVDAVLLTHPDVSQG 439 + T D+ + GR +++ G + P +++ +++ P +S Sbjct: 304 PVIRYRTRDLTALLPPTARAMRRLAKITGRSDDMLIVRGVNVFPSQIEEIVVALPLLSGQ 363 Query: 440 VAFGVPDEKYGEEINCAVIPREG--TTVTEEDIKAFCKKNLAAFK----VPKRVFITDN- 492 + + + + ++ AV R +VT+ + A ++ K V V + Sbjct: 364 FQITLSRDGHMDRLDLAVELRSEAAASVTDGERAALARELQHRIKTMVGVSSGVTVLAAG 423 Query: 493 -LPKTASGKIQRRIVAQH 509 +P TA+GK +R I + Sbjct: 424 GIPATATGKARRVIDRRQ 441 Score = 30.1 bits (66), Expect = 2.2, Method: Composition-based stats. Identities = 17/110 (15%), Positives = 35/110 (31%), Gaps = 16/110 (14%) Query: 8 GLLENVAK--KFPDRRALSVSGKFNLTHARLHDLIERAASRLVSDAGIKPGDVVALTFPN 65 ++ A + + + T A + RAA G +PGD L Sbjct: 93 QVVRVHASSGTTGKPTVVGYTARDIDTWANVTARSIRAA-------GGRPGDT--LHNAF 143 Query: 66 TVEFVIMFLAVIR----ARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSK 111 L + P++ T ++ + + D + K++L + Sbjct: 144 GYGLFTGGLGIHYGAERLGCMVVPMSGGQTEKQVQL-IRDFEPKIILVTP 192 >2Y4N-A nrPDB Length = 437 Score = 80.5 bits (197), Expect = 2e-15, Method: Composition-based stats. Identities = 55/363 (15%), Positives = 114/363 (31%), Gaps = 43/363 (11%) Query: 162 DDGALFLHTSGTTSRPKGVPLTQLNLASSVKNIKAVYKLTESDSTVIVLPLFHVHGLLAG 221 D + +SGTT +P V T ++ + + + + V + +GL G Sbjct: 90 DRISRIHASSGTTGKPTVVGYTAADIDTWANLVARSIRAAGARRGDKVHVSY-GYGLFTG 148 Query: 222 LLSSLGAG--AAVTLPAAGRFSATTFWPDMKKYNATWYTAVPTIHQIILDR-HASHPETE 278 L + A +T+ G ++ + P+ I D + Sbjct: 149 GLGAHYGAERAGLTVIPFGGGQTEKQVQLIQDFRPDIIMVTPSYMLSIADEIERQGLDPV 208 Query: 279 YPKLRFIRSCSASLAPVILSRLEEAFGAPVLEAYAMTEATHLMSSNPLPEEGPHKPGSVG 338 LR + + +E+ G ++ Y ++E ++ E G Sbjct: 209 QSSLRIGIFGAEPWTNDMRVAIEQRMGIDAVDIYGLSEVMGPGVASECVETKD------G 262 Query: 339 KPVGQE---MAILN-EKGEIQEPNNKGEVCIRGPNVTKGYKNNPEANKAGFEFGWFHTGD 394 + ++ I++ E GE+ GE+ K + T D Sbjct: 263 PTIWEDHFYPEIIDPETGEVLPDGELGELVFTS------------LTKEALPIIRYRTRD 310 Query: 395 IGYFDTDGYLH-------LVGRIKELINRGGEKISPIEVDAVLLTHPDVSQGVAFGVPDE 447 + G + GR +++ G + P +++ LL ++ + E Sbjct: 311 LTRLLP-GTARTMRRMEKITGRSDDMMIVRGVNVFPTQIEEQLLKQRALAPHYQIVLTKE 369 Query: 448 KYGEEINCAVIPREGTTVTEEDIKAFCKKNLAAFKVPKRV---FITDNLPKT----ASGK 500 + + V P T I+ K A+ + + + + LP + GK Sbjct: 370 GPLDVLTLNVEPCPETAPDTAAIQ--VAKQALAYDIKSLIGVTAVINVLPVNGIERSVGK 427 Query: 501 IQR 503 +R Sbjct: 428 ARR 430 >6HIV-BC nrPDB Length = 523 Score = 79.0 bits (193), Expect = 5e-15, Method: Composition-based stats. Identities = 72/464 (15%), Positives = 140/464 (30%), Gaps = 63/464 (13%) Query: 3 SDTLSGLLENVAKKFPDRRALSVSGK-FNLTHARLHDLIERAASRLVSDAGIKPGDVVAL 61 + + ++K + L + + A + E A L+ G++PG V Sbjct: 61 DQLVGYYVNIQSRKMYYKDFLRIEHQAVRWAFADIRKNSEALAHGLLQT-GLRPGQRVLA 119 Query: 62 TFPNTVEFVIMFLAVIRARATAAPL-NAAYTAEEFEFYLSDSDSKLLLT-----SKEGNA 115 P E ++ LA + A A + + +A++ FYL++ L+ E Sbjct: 120 IQPCNCETFVLQLACAKIGALLAVVPHHNISADKLRFYLNEFQPHHLIAREWIVVPEVKQ 179 Query: 116 PAQEAASKLKISHVTATLLDAGSDLVLSVADSDSVVDSAT-------------------- 155 + + + + G + Sbjct: 180 GVLVERNMHFWDMIYNVIPELGLSYPGQRFQWVHSQEFFFLKKVVITDHNMNLLGVTPMR 239 Query: 156 ------------------ELVNHPDDGALFLHTSGTTSRPKG-VPLTQLNLASSVKNIKA 196 + HPDD L L K + + N ++ Sbjct: 240 KMLVWGPFSYYEQRLRRLSALLHPDDPILALEDPHPALEDKLHITYSHRNCINAGFLFGN 299 Query: 197 VYKLTESDSTVIVLPLFHVH--GLLAGLLSSLGAGAAVTLPAAGRFSATTFWPDMKK--- 251 + L V+P HV G + ++L GA + + F+ ++K Sbjct: 300 LMGLKAESR-FGVMPNHHVDPVGAIVAPYAALTTGAVLVHIHSDMFTDDHAINGIEKLCV 358 Query: 252 YNATWYTAVPTIHQIILDRHASHPETEYPKLRFIRS---CSAS-LAPVILSRLEEAFGAP 307 + ++L + +Y L+++ S + L +L + G Sbjct: 359 EEVVGMLGKKSDFDLLLRHAGNFDADQYEHLKWVVLFEDASEPTVGDEYLQKLAKELGLE 418 Query: 308 VLEAY-AMTEATHLMSSNPLPE-EGPHKPGSVGKPVGQEMAILNEKGEIQEPNNKGEVCI 365 + + E+ +++ L P K VG I N +G + + Sbjct: 419 DVFVFRGPLESAYMVMWRSLKRARWEMVPHVEAKVVGDRGT---ADARILAANTRGNLKL 475 Query: 366 RGPNVTKGYKNN-PEANKAGFEFGWFHTGDIGYFDTDGYLHLVG 408 +GP+++ GY NN + E G+ T D G L L G Sbjct: 476 KGPHISAGYYNNAGLLTELVDERGFCSTSREAVMDERGQLTLHG 519 >5YHV-A nrPDB Length = 394 Score = 34.7 bits (78), Expect = 0.11, Method: Composition-based stats. Identities = 24/180 (13%), Positives = 57/180 (31%), Gaps = 8/180 (4%) Query: 38 DLIERAASRLVSDAGIKPG-DVVALTFPNTVEFVIMFLAVIRARATAAPLNAAYTAEEFE 96 +L + A+ GI D V +T ++ F++ FLA A A + Y Sbjct: 78 ELRDAIAADYQRRHGITVEPDAVVITTGSSGGFLLAFLACFDAGDRVAMASPGYPCYRNI 137 Query: 97 FYLSDSDSKLLLTSKEGN-APAQEAASKLKISHVTATLL----DAGSDLVLSVADSDSVV 151 + + + P + +++ + G+ + + + Sbjct: 138 LSALGCEVVEIPCGPQTRFQPTAQMLAEIDPPLRGVVVASPANPTGTVIPPEELAAIASW 197 Query: 152 DSATELVNHPDDGALFLHTSGTTSRPKGVPLTQLNLASSVKNIKAVYKLTESDSTVIVLP 211 A+++ D+ L G ++ + V + Y +T +++P Sbjct: 198 CDASDVRLISDEVYHGLVYQGAPQTSCAWQTSRNAVV--VNSFSKYYAMTGWRLGWLLVP 255 >3D02-A nrPDB Length = 303 Score = 32.0 bits (71), Expect = 0.74, Method: Composition-based stats. Identities = 16/90 (17%), Positives = 33/90 (36%), Gaps = 3/90 (3%) Query: 277 TEYPKLRFIRSCSASLAPVILSRLEEAFGAPVLEAYAM---TEATHLMSSNPLPEEGPHK 333 YP L+ + S ++ ++E + Y M ++A L+ S + E + Sbjct: 185 KTYPDLKAVVSFGSNGPIGAGRAVKEKRAKNKVAVYGMMIPSQAASLIKSGDITEGITYD 244 Query: 334 PGSVGKPVGQEMAILNEKGEIQEPNNKGEV 363 P + G + + L I+ E+ Sbjct: 245 PATAGYALAAVASTLLNGKTIEPGFELKEL 274 >5YLO-A nrPDB Length = 271 Score = 31.2 bits (69), Expect = 1.1, Method: Composition-based stats. Identities = 24/116 (20%), Positives = 39/116 (33%), Gaps = 6/116 (5%) Query: 235 PAAGRFSATTFWPDMKKYNATWYTAVPTIHQIILDRHASHPETEYPKLRFIRSCSAS--- 291 P R A W + + +PT+ + + A + P +R + + Sbjct: 6 PLQTRVEAGIAWLVLNRPQQRNALDIPTLEALHVRLDACERD---PAVRAVVLGGSGRSF 62 Query: 292 LAPVILSRLEEAFGAPVLEAYAMTEATHLMSSNPLPEEGPHKPGSVGKPVGQEMAI 347 A L+ A LE+Y TEA H + + P G VG M + Sbjct: 63 CAGADLAEWAAAEARGELESYGWTEAAHALMGRLHALDKPTVAAVNGSAVGAGMDL 118 >5YCL-B nrPDB Length = 101 Score = 30.8 bits (68), Expect = 1.5, Method: Composition-based stats. Identities = 10/25 (40%), Positives = 13/25 (52%) Query: 362 EVCIRGPNVTKGYKNNPEANKAGFE 386 E+ G + KGY PE+ KA F Sbjct: 24 ELVALGNTIAKGYFKKPESLKAVFP 48 >2EG4-A nrPDB Length = 230 Score = 30.8 bits (68), Expect = 1.5, Method: Composition-based stats. Identities = 6/37 (16%), Positives = 13/37 (35%) Query: 45 SRLVSDAGIKPGDVVALTFPNTVEFVIMFLAVIRARA 81 L+ G++PG V + + + F + Sbjct: 173 EGLLERLGLQPGQEVGVYCHSGARSAVAFFVLRSLGV 209 >3IP1-A nrPDB Length = 404 Score = 30.8 bits (68), Expect = 1.6, Method: Composition-based stats. Identities = 28/141 (19%), Positives = 49/141 (34%), Gaps = 9/141 (6%) Query: 14 AKKFPDRRALSVSGKFNL--THARLHDLIERAASRLVSDAGIKPGDVV----ALTFPNTV 67 A+ FP+ FN+ A + + A L G+ GD + +L P +V Sbjct: 140 AEGFPNHCENLNELGFNVDGAFAEYVKVDAKYAWSLRELEGVYEGDRLFLAGSLVEPTSV 199 Query: 68 EF--VIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSKEGNAPAQEAASKLK 125 + VI+ IR L L + + ++ S E + + A +L Sbjct: 200 AYNAVIVRGGGIRPGDNVVILGGGPIGLAAVAILKHAGASKVILS-EPSEVRRNLAKELG 258 Query: 126 ISHVTATLLDAGSDLVLSVAD 146 HV + + VL + Sbjct: 259 ADHVIDPTKENFVEAVLDYTN 279 >3ZQ4-A nrPDB Length = 555 Score = 29.7 bits (65), Expect = 2.9, Method: Composition-based stats. Identities = 30/171 (17%), Positives = 55/171 (32%), Gaps = 20/171 (11%) Query: 15 KKFPDRRALSVSGKFNLTHARLHDLIERAASRLVSDAGIKPGDVVALTF----PNTVEFV 70 + ++ + +G A L R A+ I PGD V + NT+ Sbjct: 287 RMPANKVTILCTGSQGEPMAAL----SRIANGTHRQISINPGDTVVFSSSPIPGNTISVS 342 Query: 71 IMFLAVIRARA--TAAPLNAAYTA-----EEFEFYLSDSDSKLLLTSKEGNAPAQEAASK 123 + RA A PLN +T+ EE + L K G Q+ K Sbjct: 343 RTINQLYRAGAEVIHGPLNDIHTSGHGGQEEQKLMLRLIKPKF-FMPIHGEYRMQKMHVK 401 Query: 124 LKISHVTATLLDAGSDLVLSVADSDSVVDSATELVNHPDDGALFLHTSGTT 174 L + + ++ + ++ + G++++ SG Sbjct: 402 LATD----CGIPEENCFIMDNGEVLALKGDEASVAGKIPSGSVYIDGSGIG 448 >5NPY-A nrPDB Length = 618 Score = 29.3 bits (64), Expect = 4.5, Method: Composition-based stats. Identities = 28/150 (18%), Positives = 50/150 (33%), Gaps = 33/150 (22%) Query: 312 YAMTEATHLMSSNP---LPEEGPHKPGSVGKPVGQEMAILNEKGEIQEPNNKGEVCIRGP 368 Y +T + +++S+ +P EG GK + PN GE+ I Sbjct: 64 YGVTGSGNVLSNKDGEYMPSEGEFHMAYQGKGWF-----------VIGPNKNGEMTINKD 112 Query: 369 NVTKGYKNNPEANKAGFEFGWFHTGDIGYFDTDGYLHL--------------VGRIKELI 414 +K K + +A + D +GY R +++ Sbjct: 113 GFSK--KQDNFLTRA---GNFARDADGYLVTPEGYYVYGIDLKKIKDGTLNSTARDEDIE 167 Query: 415 NRGGEKISPIEVDAVLLTHPDVSQGVAFGV 444 G +SP+++ L P +S V V Sbjct: 168 KLHGNTLSPLQIPQDLTYQPVLSTKVGISV 197 >2OGE-A nrPDB Length = 399 Score = 29.3 bits (64), Expect = 4.7, Method: Composition-based stats. Identities = 12/41 (29%), Positives = 19/41 (46%), Gaps = 3/41 (7%) Query: 48 VSDAGIKPGDVVALTFPNTVEFVIMFLAVIRARATAAPLNA 88 + GI PGD V + + ++ +LAV AT P+ Sbjct: 95 LRGLGIGPGDEVIV---PSHTYIASWLAVSATGATPVPVEP 132 >4KI3-A nrPDB Length = 184 Score = 29.3 bits (64), Expect = 4.8, Method: Composition-based stats. Identities = 9/48 (18%), Positives = 23/48 (47%), Gaps = 3/48 (6%) Query: 346 AILNEKGEIQEPNNKGEVCIRGPNVTKGYKNNPEANKAGFEFG--WFH 391 A+ + G + + GE+ ++ PN+ + +P+ + + WF+ Sbjct: 26 AVTSSDGAVVQEGE-GELWVKRPNLFNWHMTSPDESVLISDGETLWFY 72 >2I2W-A nrPDB Length = 212 Score = 28.5 bits (62), Expect = 7.4, Method: Composition-based stats. Identities = 25/140 (17%), Positives = 44/140 (31%), Gaps = 24/140 (17%) Query: 35 RLHDLIERAASRLVSDAGIKPGDVVALTFPNTVEFVIMFLAVIRARATAAPLNAAYTAEE 94 L++ E A+ L DA I A+ ++ +A + + Sbjct: 29 ELNEAAETLANFLKDDANIHAIQRAAVLLADS----------FKAGGKVLSCGNGGSHCD 78 Query: 95 FEFYLSDSDSKLLLTSKEGNAPAQEAASKLKISHVTATLLDAGSDLVLSVADSDSVVDSA 154 + + L N P A + +SH++ D G + + S Sbjct: 79 AMHFAEE-----LTGRYRENRPGYPAIAISDVSHISCVGNDFGFNDIFS---------RY 124 Query: 155 TELVNHPDDGALFLHTSGTT 174 E V D L + TSG + Sbjct: 125 VEAVGREGDVLLGISTSGNS 144 >5B6A-A nrPDB Length = 288 Score = 28.1 bits (61), Expect = 9.1, Method: Composition-based stats. Identities = 17/121 (14%), Positives = 38/121 (31%), Gaps = 6/121 (4%) Query: 94 EFEFYLSDSDSKLL-LTSKEGNAPAQEAASKLKISHVTATLLDAGSDL-VLSVADSDSVV 151 + + ++ + L L P + ++S A +D + + DS Sbjct: 97 DVVARIKQANPRALYLCDPVMGHPEKGCIVAPEVSDFLLEEAAAVADYLCPNQLELDSFC 156 Query: 152 DSATELVNHPDDGALFLHTSGTTSRPKGVPLTQLNLASSVKNIKAVYKLTESDSTVIVLP 211 D + + A L G P+ + + LN + + + + + P Sbjct: 157 DRQPNSLADCVEMARSLLARG----PRAILVKHLNYPGKAGDTFEMLLVAADQAWHLQRP 212 Query: 212 L 212 L Sbjct: 213 L 213 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.312 0.132 0.336 Lambda K H 0.267 0.0404 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 18,043,523 Number of Sequences: 36641 Number of extensions: 746272 Number of successful extensions: 2693 Number of sequences better than 10.0: 66 Number of HSP's better than 10.0 without gapping: 99 Number of HSP's successfully gapped in prelim test: 23 Number of HSP's that attempted gapping in prelim test: 2134 Number of HSP's gapped (non-prelim): 146 length of query: 514 length of database: 10,336,785 effective HSP length: 101 effective length of query: 413 effective length of database: 6,636,044 effective search space: 2740686172 effective search space used: 2740686172 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.4 bits) S2: 61 (28.1 bits)