BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q9SIE1 (475 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 5WMH-A nrPDB 967 0.0 1J32-A nrPDB 339 2e-93 6F77-B nrPDB 324 6e-89 6F35-A nrPDB 302 2e-82 1GC4-A nrPDB 287 8e-78 1GDE-A nrPDB 276 1e-74 1O4S-A nrPDB 272 2e-73 4MY5-A nrPDB 213 2e-55 2Z61-A nrPDB 205 3e-53 1XI9-A nrPDB 183 2e-46 1U08-A nrPDB 167 9e-42 2ZJG-A nrPDB 165 3e-41 4WP0-A nrPDB 159 3e-39 3FVS-A nrPDB 159 3e-39 2O0R-A nrPDB 154 6e-38 4CVQ-A nrPDB 149 3e-36 1V2E-A nrPDB 144 8e-35 1YIY-A nrPDB 137 1e-32 2X5D-A nrPDB 135 3e-32 2GB3-A nrPDB 135 3e-32 5YHV-A nrPDB 125 3e-29 3H14-A nrPDB 123 2e-28 1BW0-A nrPDB 119 2e-27 3ELE-A nrPDB 117 1e-26 4IX8-A nrPDB 106 2e-23 3B46-A nrPDB 105 5e-23 3ASB-A nrPDB 103 2e-22 3T32-A nrPDB 102 5e-22 2O1B-A nrPDB 100 3e-21 4DQ6-A nrPDB 99 5e-21 5Z0Q-C nrPDB 99 5e-21 3B1C-A nrPDB 97 1e-20 2DOU-A nrPDB 96 5e-20 3L8A-A nrPDB 92 4e-19 1C7O-A nrPDB 91 8e-19 3FDB-A nrPDB 91 1e-18 3JTX-A nrPDB 90 2e-18 3DYD-A nrPDB 88 1e-17 4R2N-A nrPDB 86 3e-17 3PDX-A nrPDB 86 5e-17 3NRA-A nrPDB 82 5e-16 4FL0-A nrPDB 81 1e-15 2ZC0-A nrPDB 79 4e-15 1IAY-A nrPDB 77 1e-14 3QGU-A nrPDB 75 4e-14 3OP7-A nrPDB 75 6e-14 1IJI-A nrPDB 72 5e-13 3AV7-A nrPDB 72 7e-13 1X0M-A nrPDB 72 7e-13 3F6T-A nrPDB 70 2e-12 2ZY3-A nrPDB 68 1e-11 4GDY-A nrPDB 67 2e-11 3FDD-A nrPDB 65 8e-11 3EUC-A nrPDB 64 2e-10 3EZS-A nrPDB 64 2e-10 3CQ5-A nrPDB 63 2e-10 3IHJ-A nrPDB 63 2e-10 4RAE-A nrPDB 63 3e-10 3TCM-A nrPDB 62 5e-10 2ZY2-A nrPDB 62 5e-10 1M4N-A nrPDB 62 5e-10 3HDO-A nrPDB 60 1e-09 3EI8-A nrPDB 60 3e-09 2ZYJ-A nrPDB 58 8e-09 3GET-A nrPDB 57 2e-08 3DZZ-A nrPDB 55 7e-08 4M2J-A nrPDB 54 1e-07 3LY1-A nrPDB 54 1e-07 4N0B-A nrPDB 53 3e-07 1D2F-A nrPDB 53 3e-07 5X03-B nrPDB 52 4e-07 3FFH-A nrPDB 52 4e-07 1UU1-A nrPDB 52 7e-07 3FTB-A nrPDB 50 2e-06 3FKD-A nrPDB 50 2e-06 6HNB-A nrPDB 50 3e-06 3P1T-A nrPDB 48 1e-05 2X5F-A nrPDB 48 1e-05 3NYS-A nrPDB 44 1e-04 6HNV-A nrPDB 42 6e-04 1LC8-A nrPDB 42 6e-04 2C81-A nrPDB 42 6e-04 3UWC-A nrPDB 42 8e-04 3DR4-A nrPDB 42 8e-04 4WBT-A nrPDB 40 0.002 3G7Q-A nrPDB 40 0.003 4JE5-A nrPDB 40 0.003 5K8B-A nrPDB 38 0.010 1MDZ-A nrPDB 37 0.015 5DJ3-A nrPDB 37 0.015 3IF2-A nrPDB 37 0.028 5W70-A nrPDB 34 0.12 4ZWV-A nrPDB 34 0.14 4PIW-A nrPDB 33 0.18 1TAR-A nrPDB 33 0.18 4K2M-A nrPDB 33 0.21 3FED-A nrPDB 33 0.26 1M6S-A nrPDB 33 0.40 4WD2-A nrPDB 32 0.46 4W91-A nrPDB 32 0.54 2OGE-A nrPDB 32 0.64 1B9H-A nrPDB 32 0.64 3MEB-A nrPDB 32 0.73 6BLG-A nrPDB 31 1.0 3G0T-A nrPDB 31 1.1 6CJB-A nrPDB 31 1.4 5ILB-A nrPDB 31 1.4 3JCM-G nrPDB 31 1.5 4MCR-A nrPDB 30 1.5 5JYK-A nrPDB 30 2.4 6J9S-A nrPDB 28 9.2 >5WMH-A nrPDB Length = 475 Score = 967 bits (2499), Expect = 0.0, Method: Compositional matrix adjust. Identities = 475/475 (100%), Positives = 475/475 (100%) Query: 1 MASQSSVAVISSAAARGESFPDSKKPIGSVRFQQPLRLSFSYCKSGNMSSRICAMAKPND 60 MASQSSVAVISSAAARGESFPDSKKPIGSVRFQQPLRLSFSYCKSGNMSSRICAMAKPND Sbjct: 1 MASQSSVAVISSAAARGESFPDSKKPIGSVRFQQPLRLSFSYCKSGNMSSRICAMAKPND 60 Query: 61 AETLSSSVDMSLSPRVQSLKPSKTMVITDLAATLVQSGVPVIRLAAGEPDFDTPKVVAEA 120 AETLSSSVDMSLSPRVQSLKPSKTMVITDLAATLVQSGVPVIRLAAGEPDFDTPKVVAEA Sbjct: 61 AETLSSSVDMSLSPRVQSLKPSKTMVITDLAATLVQSGVPVIRLAAGEPDFDTPKVVAEA 120 Query: 121 GINAIREGFTRYTLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVC 180 GINAIREGFTRYTLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVC Sbjct: 121 GINAIREGFTRYTLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVC 180 Query: 181 SPGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCS 240 SPGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCS Sbjct: 181 SPGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCS 240 Query: 241 PSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLT 300 PSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLT Sbjct: 241 PSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLT 300 Query: 301 VNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGET 360 VNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGET Sbjct: 301 VNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGET 360 Query: 361 VAEMVKAYRERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSL 420 VAEMVKAYRERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSL Sbjct: 361 VAEMVKAYRERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSL 420 Query: 421 ALYFLDKFQVAMVPGDAFGDDSCIRISYATSLDVLQAAVEKIRKALEPLRATVSV 475 ALYFLDKFQVAMVPGDAFGDDSCIRISYATSLDVLQAAVEKIRKALEPLRATVSV Sbjct: 421 ALYFLDKFQVAMVPGDAFGDDSCIRISYATSLDVLQAAVEKIRKALEPLRATVSV 475 >1J32-A nrPDB Length = 388 Score = 339 bits (869), Expect = 2e-93, Method: Compositional matrix adjust. Identities = 176/399 (44%), Positives = 251/399 (62%), Gaps = 15/399 (3%) Query: 70 MSLSPRVQSLKPSKTMVITDLAATLVQSGVPVIRLAAGEPDFDTPKVVAEAGINAIREGF 129 M L+ RV+S+ PS T++I A + G+ V +AGEPDF+TPK + EA A+ +G Sbjct: 1 MKLAARVESVSPSMTLIIDAKAKAMKAEGIDVCSFSAGEPDFNTPKHIVEAAKAALEQGK 60 Query: 130 TRYTLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIP 189 TRY AG LREAI +KL+ +NGL Y D ILV+NG KQS+ +LA+ PGDEVIIP Sbjct: 61 TRYGPAAGEPRLREAIAQKLQRDNGLCYGADNILVTNGGKQSIFNLMLAMIEPGDEVIIP 120 Query: 190 APYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVY 249 AP+WVSY E +LA+ TPV++PT + F + P+ + +T K++LL+ +PSNPTG VY Sbjct: 121 APFWVSYPEMVKLAEGTPVILPTTVETQFKVSPEQIRQAITPKTKLLVFNTPSNPTGMVY 180 Query: 250 PKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSF-ASLPDMYERTLTVNGFSKAF 308 + IA+ +A L VLSDEIYE I+Y A H S A+ P+ YER++ +GF+K + Sbjct: 181 TPDEVRAIAQ-VAVEAGLWVLSDEIYEKILYDDAQHLSIGAASPEAYERSVVCSGFAKTY 239 Query: 309 AMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAY 368 AMTGWR+G+LAGP +V A +K+QG +S + AQ +AA + + V EM+ A+ Sbjct: 240 AMTGWRVGFLAGPVPLVKAATKIQGHSTSNVCTFAQYGAIAAY---ENSQDCVQEMLAAF 296 Query: 369 RERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKF 428 ERR +++ +L + G++ +P GAFY+F + G ++ S L LD+ Sbjct: 297 AERRRYMLDALNAMPGLECPKPDGAFYMFPSIA------KTGRSSLDFCSEL----LDQH 346 Query: 429 QVAMVPGDAFGDDSCIRISYATSLDVLQAAVEKIRKALE 467 QVA VPG AFG D CIR+SYAT LD ++ +E++ K L Sbjct: 347 QVATVPGAAFGADDCIRLSYATDLDTIKRGMERLEKFLH 385 >6F77-B nrPDB Length = 400 Score = 324 bits (830), Expect = 6e-89, Method: Compositional matrix adjust. Identities = 169/394 (42%), Positives = 234/394 (59%), Gaps = 4/394 (1%) Query: 72 LSPRVQSLKPSKTMVITDLAATLVQSGVPVIRLAAGEPDFDTPKVVAEAGINAIREGFTR 131 L+ + +KPS T+ ++ A L G VI L AGEPDFDTP + +A I+AI G T+ Sbjct: 4 LADALSRVKPSATIAVSQKARELKAKGRDVIGLGAGEPDFDTPDNIKKAAIDAIDRGETK 63 Query: 132 YTLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAP 191 YT +GI ELREAI +K K EN L Y Q +V G KQ L A +A +PGDEV+IPAP Sbjct: 64 YTPVSGIPELREAIAKKFKRENNLDYTAAQTIVGTGGKQILFNAFMATLNPGDEVVIPAP 123 Query: 192 YWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPK 251 YWVSY E L TPV +PT+ NNF L +DL+ +T K++ + SPSNP+G+ Y Sbjct: 124 YWVSYPEMVALCGGTPVFVPTRQENNFKLKAEDLDRAITPKTKWFVFNSPSNPSGAAYSH 183 Query: 252 SLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASL-PDMYERTLTVNGFSKAFAM 310 L+ + ++ KHP + VL+D++YEH+ Y + + P +YERTLT+NG SKA+AM Sbjct: 184 EELKALTDVLMKHPHVWVLTDDMYEHLTYGDFRFATPVEVEPGLYERTLTMNGVSKAYAM 243 Query: 311 TGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRE 370 TGWR+GY AGP H++ A +QGQ +SGA+SIAQ A V AL + + + ++ Sbjct: 244 TGWRIGYAAGPLHLIKAMDMIQGQQTSGAASIAQWAAVEAL---NGPQDFIGRNKEIFQG 300 Query: 371 RRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQV 430 RRD +V L KG+ P+GAFY++ + G A +I L+ V Sbjct: 301 RRDLVVSMLNQAKGISCPTPEGAFYVYPSCAGLIGKTAPSGKVIETDEDFVSELLETEGV 360 Query: 431 AMVPGDAFGDDSCIRISYATSLDVLQAAVEKIRK 464 A+V G AFG RISYATS +L+ A +I++ Sbjct: 361 AVVHGSAFGLGPNFRISYATSEALLEEACRRIQR 394 >6F35-A nrPDB Length = 410 Score = 302 bits (774), Expect = 2e-82, Method: Compositional matrix adjust. Identities = 163/396 (41%), Positives = 234/396 (59%), Gaps = 4/396 (1%) Query: 75 RVQSLKPSKTMVITDLAATLVQSGVPVIRLAAGEPDFDTPKVVAEAGINAIREGFTRYTL 134 R+ S+ S+ + I AA + + G PVI L AGEPDFDTP+ V +A +AI G T+YT Sbjct: 17 RISSIGVSEILKIGARAAAMKREGKPVIILGAGEPDFDTPEHVKQAASDAIHRGETKYTA 76 Query: 135 NAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWV 194 G EL++AI K + ENGL+Y D+I V+ GAKQ L A++A PGDEVIIP PYW Sbjct: 77 LDGTPELKKAIREKFQRENGLAYELDEITVATGAKQILFNAMMASLDPGDEVIIPTPYWT 136 Query: 195 SYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLL 254 SY++ + + PV+I S+ F L + LE+ +T ++R ++L SPSNP+G+ Y + Sbjct: 137 SYSDIVHICEGKPVLIACDASSGFRLTAEKLEAAITPRTRWVLLNSPSNPSGAAYSAADY 196 Query: 255 EEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASL-PDMYERTLTVNGFSKAFAMTGW 313 + ++ +HP + +L D++YEHI+Y + A L P + RTLTVNG SKA+AMTGW Sbjct: 197 RPLLEVLLRHPHVWLLVDDMYEHIVYDGFRFVTPAQLEPGLKNRTLTVNGVSKAYAMTGW 256 Query: 314 RLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRD 373 R+GY GP+ ++ A + +Q Q +S SSI+Q A V AL + + E ++++ RRD Sbjct: 257 RIGYAGGPRELIKAMAVVQSQATSCPSSISQAASVVAL---NGPQDFLKERTESFQRRRD 313 Query: 374 FLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVAMV 433 +V L I G+ P+GAFY F + G I + Y L+ VA+V Sbjct: 314 LVVNGLNAIDGLDCRVPEGAFYTFSGCAGVLGKVTPSGKRIKTDTDFCAYLLEDAHVAVV 373 Query: 434 PGDAFGDDSCIRISYATSLDVLQAAVEKIRKALEPL 469 PG AFG RISYATS L+ A+E+I A + L Sbjct: 374 PGSAFGLSPFFRISYATSEAELKEALERIAAACDRL 409 >1GC4-A nrPDB Length = 385 Score = 287 bits (734), Expect = 8e-78, Method: Compositional matrix adjust. Identities = 163/395 (41%), Positives = 231/395 (58%), Gaps = 16/395 (4%) Query: 72 LSPRVQSLKPSKTMVITDLAATLVQSGVPVIRLAAGEPDFDTPKVVAEAGINAIREGFTR 131 LS RVQ++KP + + A L + GV ++ L AGEPDFDTP+ V EA A+ +G T+ Sbjct: 4 LSRRVQAMKPDAVVAVNAKALELRRQGVDLVALTAGEPDFDTPEHVKEAARRALAQGKTK 63 Query: 132 YTLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAP 191 Y AGI ELREA+ K + ENGLS P++ +V+ G Q+L A+ PGDEVI+ +P Sbjct: 64 YAPPAGIPELREALAEKFRRENGLSVTPEETIVTVGGSQALFNLFQAILDPGDEVIVLSP 123 Query: 192 YWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPK 251 YWVSY E R A V + T F+ DP+ + +T +++ L++ SP+NPTG+VYPK Sbjct: 124 YWVSYPEMVRFAGGVVVEVETLPEEGFVPDPERVRRAITPRTKALVVNSPNNPTGAVYPK 183 Query: 252 SLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMT 311 +LE +AR+ +H LV SDEIYEH++Y + P E TLTVNG +KAFAMT Sbjct: 184 EVLEALARLAVEHDFYLV-SDEIYEHLLYEGEHFSPGRVAP---EHTLTVNGAAKAFAMT 239 Query: 312 GWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRER 371 GWR+GY GPK ++ A + + Q ++ +IAQ A + AL +A V +AYR R Sbjct: 240 GWRIGYACGPKEVIKAMASVSRQSTTSPDTIAQWATLEALTNQEASRAFVEMAREAYRRR 299 Query: 372 RDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVA 431 RD L++ L + G+K P GAFY+ +D S + D A L+ VA Sbjct: 300 RDLLLEGLTAL-GLKAVRPSGAFYVLMDTSP----------IAPDEVRAAERLLEA-GVA 347 Query: 432 MVPGDAFGDDSCIRISYATSLDVLQAAVEKIRKAL 466 +VPG F +R+SYATS + L+ A+E+ + L Sbjct: 348 VVPGTDFAAFGHVRLSYATSEENLRKALERFARVL 382 >1GDE-A nrPDB Length = 389 Score = 276 bits (706), Expect = 1e-74, Method: Compositional matrix adjust. Identities = 164/401 (40%), Positives = 234/401 (58%), Gaps = 20/401 (4%) Query: 70 MSLSPRVQSLKPSKTMVITDLAATLVQSGVPVIRLAAGEPDFDTPKVVAEAGINAIREGF 129 M+LS R++ + S+ + D+AA + VI L GEPDFDTP+ + E A+ +G Sbjct: 1 MALSDRLELVSASEIRKLFDIAAGMKD----VISLGIGEPDFDTPQHIKEYAKEALDKGL 56 Query: 130 TRYTLNAGITELREAICRKLKEENGLSYAPD-QILVSNGAKQSLLQAVLAVCSPGDEVII 188 T Y N G+ ELREAI KLK++NG+ P +I+V GA Q+ L + A G+EV+I Sbjct: 57 THYGPNIGLLELREAIAEKLKKQNGIEADPKTEIMVLLGANQAFLMGLSAFLKDGEEVLI 116 Query: 189 PAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSV 248 P P +VSY LA PV +PT + F L+ +L+ +T+K+R LI+ SP NPTG+V Sbjct: 117 PTPAFVSYAPAVILAGGKPVEVPTYEEDEFRLNVDELKKYVTDKTRALIINSPCNPTGAV 176 Query: 249 YPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAF 308 K LEEIA + +H L+V+SDE+YEH IY A H S ASL M+ERT+TVNGFSK F Sbjct: 177 LTKKDLEEIADFVVEHD-LIVISDEVYEHFIYDDARHYSIASLDGMFERTITVNGFSKTF 235 Query: 309 AMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAY 368 AMTGWRLG++A P I+ K Q ++ + Q A AL + + V EM K Y Sbjct: 236 AMTGWRLGFVAAPSWIIERMVKFQMYNATCPVTFIQYAAAKALK-DERSWKAVEEMRKEY 294 Query: 369 RERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKF 428 RR + K L ++ G+ +P+GAFY+F GL S + L + Sbjct: 295 DRRRKLVWKRLNEM-GLPTVKPKGAFYIF--------PRIRDTGLT--SKKFSELMLKEA 343 Query: 429 QVAMVPGDAFGD--DSCIRISYATSLDVLQAAVEKIRKALE 467 +VA+VPG AFG + +RISYAT+ + L+ A++++ + L+ Sbjct: 344 RVAVVPGSAFGKAGEGYVRISYATAYEKLEEAMDRMERVLK 384 >1O4S-A nrPDB Length = 389 Score = 272 bits (696), Expect = 2e-73, Method: Compositional matrix adjust. Identities = 149/395 (37%), Positives = 234/395 (59%), Gaps = 22/395 (5%) Query: 72 LSPRVQSLKPSKTMVITDLAATLVQSGVPVIRLAAGEPDFDTPKVVAEAGINAIREGFTR 131 +S R+ + SKTM + A L++ G VI L AGEPDF TP+ V E + +++G + Sbjct: 14 VSRRISEIPISKTMELDAKAKALIKKGEDVINLTAGEPDFPTPEPVVEEAVRFLQKGEVK 73 Query: 132 YTLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAP 191 YT GI ELRE I +++ E +PDQ++V+NGAKQ+L A +A+ PGDEVI+ +P Sbjct: 74 YTDPRGIYELREGIAKRIGERYKKDISPDQVVVTNGAKQALFNAFMALLDPGDEVIVFSP 133 Query: 192 YWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPK 251 WVSY Q LA T V+ T +S NF +++E L K++ +++ SP+NPTG VY + Sbjct: 134 VWVSYIPQIILAGGTVNVVETFMSKNFQPSLEEVEGLLVGKTKAVLINSPNNPTGVVYRR 193 Query: 252 SLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMT 311 LE + R +AK ++SDE+Y+ ++Y TS + + ++R + +NGFSK+ +MT Sbjct: 194 EFLEGLVR-LAKKRNFYIISDEVYDSLVYTDE-FTSILDVSEGFDRIVYINGFSKSHSMT 251 Query: 312 GWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRER 371 GWR+GYL + + A SK+Q +S +++AQ A + AL + + MV+ ++ER Sbjct: 252 GWRVGYLISSEKVATAVSKIQSHTTSCINTVAQYAALKALEVDN------SYMVQTFKER 305 Query: 372 RDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVA 431 ++F+V+ L + GVK EP+GAFYLF F + D L++ +VA Sbjct: 306 KNFVVERLKKM-GVKFVEPEGAFYLF-------------FKVRGDDVKFCERLLEEKKVA 351 Query: 432 MVPGDAFGDDSCIRISYATSLDVLQAAVEKIRKAL 466 +VPG AF +R+S+ATS++ L A+++I L Sbjct: 352 LVPGSAFLKPGFVRLSFATSIERLTEALDRIEDFL 386 >4MY5-A nrPDB Length = 393 Score = 213 bits (541), Expect = 2e-55, Method: Compositional matrix adjust. Identities = 136/379 (35%), Positives = 217/379 (57%), Gaps = 26/379 (6%) Query: 97 SGVP-VIRLAAGEPDFDTPKVVAEAGINAIREGFTRYTLNAGITELREAICRKLKEENGL 155 S +P V++L GEPDF TPK + EA AI + YT AG+ LR+A +KE+ L Sbjct: 29 SDIPDVLKLTLGEPDFATPKHIKEAAKRAIDADESHYTGMAGLLALRQAASAFVKEKYHL 88 Query: 156 SYAPD-QILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKI 214 +Y PD +ILV+ GA ++L ++ A+ PGD+V++PAP + Y L A V I T+ Sbjct: 89 TYNPDNEILVTIGATEALSASLTAILEPGDKVLLPAPAYPGYEPVVNLVGAEVVEIDTR- 147 Query: 215 SNNFLLDPKDLES---KLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLS 271 SN+F+L P+ LE K E + +IL P+NPTG Y + ++ +A ++ K+P + V+S Sbjct: 148 SNDFVLTPEMLEEAILKEGEALKAVILNYPTNPTGVTYSRQQIKNLAEVLKKYP-IFVIS 206 Query: 272 DEIYEHIIYAPATHTSFAS-LPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSK 330 DE+Y + Y +H S A LPD +T+ ++G SK+ AMTGWRLG + P + A K Sbjct: 207 DEVYAELTYTGESHVSIAEYLPD---QTILISGLSKSHAMTGWRLGLIFAPAVLTAQLIK 263 Query: 331 LQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLGDIKGVKISEP 390 + + A++ Q A + AL GK + M + Y +RRD++++ + +K KI +P Sbjct: 264 SHQYLVTAATTSVQFAAIEALTNGK---DDALPMKEEYIKRRDYIIEKMEAMK-FKIIKP 319 Query: 391 QGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVAMVPGDAFGD--DSCIRISY 448 GAFY+F G ++ F + D F + VA +PG AFG + +RISY Sbjct: 320 DGAFYIFAKIPVAQGQDS--FKFLQD-------FAKEKAVAFIPGVAFGKYGEGYLRISY 370 Query: 449 ATSLDVLQAAVEKIRKALE 467 A S++ ++ A++++++ +E Sbjct: 371 AASMETIKEAMKRLKEFME 389 >2Z61-A nrPDB Length = 370 Score = 205 bits (522), Expect = 3e-53, Method: Compositional matrix adjust. Identities = 129/397 (32%), Positives = 202/397 (50%), Gaps = 32/397 (8%) Query: 72 LSPRVQSLKPSKTMVITDLAATLVQSGVPVIRLAAGEPDFDTPKVVAEAGINAIREGFTR 131 LS R+ + + + M I LA L G VI L GEPDF+TPK + + GI +++EG T Sbjct: 2 LSKRLLNFESFEVMDILALAQKLESEGKKVIHLEIGEPDFNTPKPIVDEGIKSLKEGKTH 61 Query: 132 YTLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAP 191 YT + GI ELRE I K++ PD I+++ G+ L A+ ++ GDEV+I P Sbjct: 62 YTDSRGILELREKISELYKDKYKADIIPDNIIITGGSSLGLFFALSSIIDDGDEVLIQNP 121 Query: 192 YWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPK 251 + Y R A PV + + LE L++K++ +I+ SPSNP G V + Sbjct: 122 CYPCYKNFIRFLGAKPVFCDFTVES--------LEEALSDKTKAIIINSPSNPLGEVIDR 173 Query: 252 SLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMT 311 + E A ++SDEIY ++Y +++ + E+T+ +NGFSK +AMT Sbjct: 174 EIYE-----FAYENIPYIISDEIYNGLVYEGKCYSAI-EFDENLEKTILINGFSKLYAMT 227 Query: 312 GWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRER 371 GWR+GY+ I+ A KLQ + A +I+Q A + A K + M+K + R Sbjct: 228 GWRIGYVISNDEIIEAILKLQQNLFISAPTISQYAALKA--FEKETEREINSMIKEFDRR 285 Query: 372 RDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVA 431 R ++K + D G +++ P GA+Y+F + D A L + VA Sbjct: 286 RRLVLKYVKDF-GWEVNNPIGAYYVFPNIGE-------------DGREFAYKLLKEKFVA 331 Query: 432 MVPGDAFGD--DSCIRISYATSLDVLQAAVEKIRKAL 466 + PG FG + IRISYA S + ++ +E+I++ L Sbjct: 332 LTPGIGFGSKGKNYIRISYANSYENIKEGLERIKEFL 368 >1XI9-A nrPDB Length = 406 Score = 183 bits (464), Expect = 2e-46, Method: Compositional matrix adjust. Identities = 119/388 (30%), Positives = 197/388 (50%), Gaps = 27/388 (6%) Query: 91 AATLVQSGVPVIRLAAGEP---DFDTPKVVAEAGINAIREGFTRYTLNAGITELREAICR 147 A L + G+ VIRL G+P DF P+ + EA AI+EG Y + G+ ELR+AI Sbjct: 30 ARELEKKGIKVIRLNIGDPVKFDFQPPEHMKEAYCKAIKEGHNYYGDSEGLPELRKAIVE 89 Query: 148 KLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADATP 207 + K +NG+ PD + V+ ++L A+ PGDE+++P P + YT + P Sbjct: 90 REKRKNGVDITPDDVRVTAAVTEALQLIFGALLDPGDEILVPGPSYPPYTGLVKFYGGKP 149 Query: 208 VVIPTKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRL 267 V T ++ D D+ K+T++++ + + +P+NPTG++Y K LEEI I ++ + Sbjct: 150 VEYRTIEEEDWQPDIDDIRKKITDRTKAIAVINPNNPTGALYDKKTLEEILNIAGEY-EI 208 Query: 268 LVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYL--AGPKH-- 323 V+SDEIY+ + Y H S SL + +NG SK + TGWRLGY+ P++ Sbjct: 209 PVISDEIYDLMTYE-GEHISPGSLTKDVP-VIVMNGLSKVYFATGWRLGYMYFVDPENKL 266 Query: 324 --IVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLGD 381 + A +L ++ ++ AQ A +A L + + E +K +ERRD++ K L + Sbjct: 267 SEVREAIDRL-ARIRLCPNTPAQFAAIAGL---TGPMDYLKEYMKKLKERRDYIYKRLNE 322 Query: 382 IKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVAMVPGDAFGDD 441 I G+ ++PQGAFY+F G + L L V V G FG+ Sbjct: 323 IPGISTTKPQGAFYIFPKIEV---------GPWKNDKEFVLDVLHNAHVLFVHGSGFGEY 373 Query: 442 SC--IRISYATSLDVLQAAVEKIRKALE 467 R + +++L+ A+++ K ++ Sbjct: 374 GAGHFRAVFLPPIEILEEAMDRFEKFMK 401 >1U08-A nrPDB Length = 386 Score = 167 bits (423), Expect = 9e-42, Method: Compositional matrix adjust. Identities = 115/388 (29%), Positives = 195/388 (50%), Gaps = 26/388 (6%) Query: 84 TMVITDLAATLVQSGVPVIRLAAGEPDFDTPKVVAEAGINAIREGFTRYTLNAGITELRE 143 T + T ++A Q I L+ G PDFD P+ + E + + +G +Y G+ LRE Sbjct: 17 TTIFTQMSALAQQHQA--INLSQGFPDFDGPRYLQERLAHHVAQGANQYAPMTGVQALRE 74 Query: 144 AICRKLKEENGLSYAPD---QILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQA 200 AI +K + G Y PD I V+ GA ++L A+ A+ GDEVI P + SY Sbjct: 75 AIAQKTERLYG--YQPDADSDITVTAGATEALYAAITALVRNGDEVICFDPSYDSYAPAI 132 Query: 201 RLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARI 260 L+ + + +F +D ++ + L+E++RL+IL +P NP+ +V+ ++ + + Sbjct: 133 ALSGGIVKRMALQ-PPHFRVDWQEFAALLSERTRLVILNTPHNPSATVWQQADFAALWQA 191 Query: 261 IAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYLAG 320 IA H + V+SDE+YEHI ++ H S + P + ER + V+ F K + MTGW++GY Sbjct: 192 IAGH-EIFVISDEVYEHINFSQQGHASVLAHPQLRERAVAVSSFGKTYHMTGWKVGYCVA 250 Query: 321 PKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLG 380 P I A K+ ++ ++ AQ +A + +A E + YR++RD LV +L Sbjct: 251 PAPISAEIRKVHQYLTFSVNTPAQ---LALADMLRAEPEHYLALPDFYRQKRDILVNALN 307 Query: 381 DIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVAMVPGDAFGD 440 + + ++I +G ++L +D+SA D + + VA +P F Sbjct: 308 ESR-LEILPCEGTYFLLVDYSAVSTL---------DDVEFCQWLTQEHGVAAIPLSVFCA 357 Query: 441 D----SCIRISYATSLDVLQAAVEKIRK 464 D IR+ +A L AA E++R+ Sbjct: 358 DPFPHKLIRLCFAKKESTLLAAAERLRQ 385 >2ZJG-A nrPDB Length = 410 Score = 165 bits (418), Expect = 3e-41, Method: Compositional matrix adjust. Identities = 107/349 (30%), Positives = 170/349 (48%), Gaps = 34/349 (9%) Query: 75 RVQSLKPSKTMVITDLAATLVQSGVPVIRLAAGEPDFDTPKVVAEA--------GINAIR 126 R++ L + + T LAA V+ L G PD P V E +N Sbjct: 4 RIEGLDSNVWVEFTKLAA-----DPSVVNLGQGFPDISPPSYVKEELSKAAFIDNMNQYT 58 Query: 127 EGFTRYTLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEV 186 GF L ++ L I ++ + N ++ILV+ GA SL ++ + PGDEV Sbjct: 59 RGFGHPALVKALSCLYGKIYQRQIDPN------EEILVAVGAYGSLFNSIQGLVDPGDEV 112 Query: 187 IIPAPYWVSYTEQARLADATPVVIPTK---------ISNNFLLDPKDLESKLTEKSRLLI 237 II P++ Y R+A A PV IP + S+++ DP++LESK + K++ +I Sbjct: 113 IIMVPFYDCYEPMVRMAGAVPVFIPLRSKPTDGMKWTSSDWTFDPRELESKFSSKTKAII 172 Query: 238 LCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYER 297 L +P NP G VY + L+ IA + KH L + SDE+YE ++Y TH A+LP M+ER Sbjct: 173 LNTPHNPLGKVYTRQELQVIADLCVKHDTLCI-SDEVYEWLVYTGHTHVKIATLPGMWER 231 Query: 298 TLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAG 357 T+T+ K F++TGW+LG+ GP H++ +Q ++ Q A A + Sbjct: 232 TITIGSAGKTFSVTGWKLGWSIGPAHLIKHLQTVQQNSFYTCATPLQAALAEAFWIDIKR 291 Query: 358 GET----VAEMVKAYRERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSA 402 + + K +RD +V+ L + G+K P G +++ D S+ Sbjct: 292 MDDPECYFNSLPKELEVKRDRMVRLLNSV-GLKPIVPDGGYFIIADVSS 339 >4WP0-A nrPDB Length = 472 Score = 159 bits (401), Expect = 3e-39, Method: Compositional matrix adjust. Identities = 111/390 (28%), Positives = 181/390 (46%), Gaps = 28/390 (7%) Query: 101 VIRLAAGEPDFDTPKVVAEAGINAIREGF--TRYTLNAGITELREAICRKLKEENGLSYA 158 V+ L G PDF P EA +A+ F +YT G L + + E G Sbjct: 30 VVNLGQGFPDFPPPDFAVEAFQHAVSGDFMLNQYTKTFGYPPLTKILASFFGELLGQEID 89 Query: 159 P-DQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADATPVVI---PTKI 214 P +LV+ G +L A A+ GDEVII P++ Y +A PV + P I Sbjct: 90 PLRNVLVTVGGYGALFTAFQALVDEGDEVIIIEPFFDCYEPMTMMAGGRPVFVSLKPGPI 149 Query: 215 SN-------NFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRL 267 N N+ LDP +L K T +++ L+L +P+NP G V+ + LE +A + +H + Sbjct: 150 QNGELGSSSNWQLDPMELAGKFTSRTKALVLNTPNNPLGKVFSREELELVASLCQQH-DV 208 Query: 268 LVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAA 327 + ++DE+Y+ ++Y H S ASLP M+ERTLT+ K F+ TGW++G++ GP HI+ Sbjct: 209 VCITDEVYQWMVYDGHQHISIASLPGMWERTLTIGSAGKTFSATGWKVGWVLGPDHIMKH 268 Query: 328 CSKLQGQVSSGASSIAQKAGVAALG----LGKAGGETVAEMVKAYRERRDFLVKSLGDIK 383 + + +Q A + L + + +A + RD +++SL + Sbjct: 269 LRTVHQNSVFHCPTQSQAAVAESFEREQLLFRQPSSYFVQFPQAMQRCRDHMIRSLQSV- 327 Query: 384 GVKISEPQGAFYLFIDFSAYYGSEAEGFGLIND--SSSLALYFLDKFQVAMVPGDAFGD- 440 G+K PQG+++L D S + + G +++ + + + +P F Sbjct: 328 GLKPIIPQGSYFLITDISDFKRKMPDLPGAVDEPYDRRFVKWMIKNKGLVAIPVSIFYSV 387 Query: 441 ------DSCIRISYATSLDVLQAAVEKIRK 464 D IR + LQA EK+RK Sbjct: 388 PHQKHFDHYIRFCFVKDEATLQAMDEKLRK 417 >3FVS-A nrPDB Length = 422 Score = 159 bits (401), Expect = 3e-39, Method: Compositional matrix adjust. Identities = 111/390 (28%), Positives = 181/390 (46%), Gaps = 28/390 (7%) Query: 101 VIRLAAGEPDFDTPKVVAEAGINAIREGF--TRYTLNAGITELREAICRKLKEENGLSYA 158 V+ L G PDF P EA +A+ F +YT G L + + E G Sbjct: 30 VVNLGQGFPDFPPPDFAVEAFQHAVSGDFMLNQYTKTFGYPPLTKILASFFGELLGQEID 89 Query: 159 P-DQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADATPVVI---PTKI 214 P +LV+ G +L A A+ GDEVII P++ Y +A PV + P I Sbjct: 90 PLRNVLVTVGGYGALFTAFQALVDEGDEVIIIEPFFDCYEPMTMMAGGRPVFVSLKPGPI 149 Query: 215 SN-------NFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRL 267 N N+ LDP +L K T +++ L+L +P+NP G V+ + LE +A + +H + Sbjct: 150 QNGELGSSSNWQLDPMELAGKFTSRTKALVLNTPNNPLGKVFSREELELVASLCQQH-DV 208 Query: 268 LVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAA 327 + ++DE+Y+ ++Y H S ASLP M+ERTLT+ K F+ TGW++G++ GP HI+ Sbjct: 209 VCITDEVYQWMVYDGHQHISIASLPGMWERTLTIGSAGKTFSATGWKVGWVLGPDHIMKH 268 Query: 328 CSKLQGQVSSGASSIAQKAGVAALG----LGKAGGETVAEMVKAYRERRDFLVKSLGDIK 383 + + +Q A + L + + +A + RD +++SL + Sbjct: 269 LRTVHQNSVFHCPTQSQAAVAESFEREQLLFRQPSSYFVQFPQAMQRCRDHMIRSLQSV- 327 Query: 384 GVKISEPQGAFYLFIDFSAYYGSEAEGFGLIND--SSSLALYFLDKFQVAMVPGDAFGD- 440 G+K PQG+++L D S + + G +++ + + + +P F Sbjct: 328 GLKPIIPQGSYFLITDISDFKRKMPDLPGAVDEPYDRRFVKWMIKNKGLVAIPVSIFYSV 387 Query: 441 ------DSCIRISYATSLDVLQAAVEKIRK 464 D IR + LQA EK+RK Sbjct: 388 PHQKHFDHYIRFCFVKDEATLQAMDEKLRK 417 >2O0R-A nrPDB Length = 411 Score = 154 bits (390), Expect = 6e-38, Method: Compositional matrix adjust. Identities = 120/402 (29%), Positives = 192/402 (47%), Gaps = 31/402 (7%) Query: 76 VQSLKPSKTMVITDLAATLVQSGVPVIRLAAGEPDFDTPKVVAEAGINAIREGFTRYTLN 135 V L+P T V +++A + G + L G PD D P + +A +AI G +Y Sbjct: 4 VSRLRPYATTVFAEMSALATRIGA--VNLGQGFPDEDGPPKMLQAAQDAIAGGVNQYPPG 61 Query: 136 AGITELREAICRKLKEENGLSYAPD-QILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWV 194 G LR AI + + G+ Y P+ ++LV+ GA +++ AVL + PG EV++ P++ Sbjct: 62 PGSAPLRRAIAAQRRRHFGVDYDPETEVLVTVGATEAIAAAVLGLVEPGSEVLLIEPFYD 121 Query: 195 SYTEQARLADATPVVIP-TKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSL 253 SY+ +A A V +P F LD L +T ++R LI+ SP NPTG+V + Sbjct: 122 SYSPVVAMAGAHRVTVPLVPDGRGFALDADALRRAVTPRTRALIINSPHNPTGAVLSATE 181 Query: 254 LEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGW 313 L IA I L+V++DE+YEH+++ A H A M ERT+T++ +K F TGW Sbjct: 182 LAAIAEIAVAA-NLVVITDEVYEHLVFDHARHLPLAGFDGMAERTITISSAAKMFNCTGW 240 Query: 314 RLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRD 373 ++G+ GP ++A + +S + Q A AL A VA + + R RRD Sbjct: 241 KIGWACGPAELIAGVRAAKQYLSYVGGAPFQPAVALALDTEDA---WVAALRNSLRARRD 297 Query: 374 FLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVAMV 433 L L +I G + + G ++L D G+ +DS+ +K VA + Sbjct: 298 RLAAGLTEI-GFAVHDSYGTYFLCAD------PRPLGY---DDSTEFCAALPEKVGVAAI 347 Query: 434 PGDAFGD-------------DSCIRISYATSLDVLQAAVEKI 462 P AF D + +R ++ D L A+ ++ Sbjct: 348 PMSAFCDPAAGQASQQADVWNHLVRFTFCKRDDTLDEAIRRL 389 >4CVQ-A nrPDB Length = 431 Score = 149 bits (376), Expect = 3e-36, Method: Compositional matrix adjust. Identities = 116/360 (32%), Positives = 186/360 (51%), Gaps = 25/360 (6%) Query: 91 AATLVQSGVPVIRLAAGEP---DFDTPKVVAEAGINAIREGFTR--YTLNAGITELREAI 145 A L + G V++L G P FD P E ++ IR T Y + G+ R+AI Sbjct: 51 AKRLEEEGNKVLKLNIGNPAPFGFDAPD---EILVDVIRNLPTAQGYCDSKGLYSARKAI 107 Query: 146 CRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADA 205 + + + I + NG + ++QA+ A+ + GDE+++PAP + +T L+ Sbjct: 108 MQHYQARGMRDVTVEDIYIGNGVSELIVQAMQALLNSGDEMLVPAPDYPLWTAAVSLSSG 167 Query: 206 TPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHP 265 V S+++ D D+ +K+T ++R +++ +P+NPTG+VY K LL EI I +H Sbjct: 168 KAVHYLCDESSDWFPDLDDIRAKITPRTRGIVIINPNNPTGAVYSKELLMEIVEIARQH- 226 Query: 266 RLLVLSDEIYEHIIYAPATHTSFASL-PDMYERTLTVNGFSKAFAMTGWRLGY--LAGP- 321 L++ +DEIY+ I+Y A H S A L PD+ T+T NG SK + + G+R G+ L GP Sbjct: 227 NLIIFADEIYDKILYDDAEHHSIAPLAPDLL--TITFNGLSKTYRVAGFRQGWMVLNGPK 284 Query: 322 KHIVAACSKLQGQVSSG--ASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSL 379 KH L+ S A+ AQ A ALG ++ E + + Y E+R+ + + Sbjct: 285 KHAKGYIEGLEMLASMRLCANVPAQHAIQTALGGYQSISEFITPGGRLY-EQRNRAWELI 343 Query: 380 GDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVAMVPGDAFG 439 DI GV +P+GA Y+F +A+ F I+D + L FL + +V +V G AF Sbjct: 344 NDIPGVSCVKPRGALYMFPKI------DAKRFN-IHDDQKMVLDFLLQEKVLLVQGTAFN 396 >1V2E-A nrPDB Length = 381 Score = 144 bits (363), Expect = 8e-35, Method: Compositional matrix adjust. Identities = 118/404 (29%), Positives = 196/404 (48%), Gaps = 51/404 (12%) Query: 70 MSLSPRVQSLKPSKTMVITDLAATLVQSGVPVIRLAAGEPDFDTPKVVAEAGINAIREGF 129 M L PR ++ K S ++ LA L + L G P P + EA +R Sbjct: 1 MRLHPRTEAAKESIFPRMSGLAQRLG-----AVNLGQGFPSNPPPPFLLEA----VRRAL 51 Query: 130 TR---YTLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEV 186 R Y AG+ LREA+ + E P+ ++V++GA ++L + ++ PGDEV Sbjct: 52 GRQDQYAPPAGLPALREALAEEFAVE------PESVVVTSGATEALYVLLQSLVGPGDEV 105 Query: 187 IIPAPYWVSYTEQARLADATPVVIPTKIS-NNFLLDPKDLESKLTEKSRLLILCSPSNPT 245 ++ P++ Y A LA A ++ ++ F LD LE LT ++R L+L +P NPT Sbjct: 106 VVLEPFFDVYLPDAFLAGAKARLVRLDLTPEGFRLDLSALEKALTPRTRALLLNTPMNPT 165 Query: 246 GSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYA--PATHTSFASLPDMYERTLTVNG 303 G V+ + LE IAR+ H L ++SDE+Y+ + Y P FA ERT TV Sbjct: 166 GLVFGERELEAIARLARAH-DLFLISDEVYDELYYGERPRRLREFAP-----ERTFTVGS 219 Query: 304 FSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVA-ALGLGKAGGETVA 362 K TG+R+G++ GPK + + ++ Q +S ++ +AGVA AL L + G A Sbjct: 220 AGKRLEATGYRVGWIVGPKEFMPRLAGMR-QWTSFSAPTPLQAGVAEALKLARREGFYEA 278 Query: 363 EMVKAYRERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLAL 422 + + YR RRD L L + G+++ P+G ++L + + + F L+ ++ Sbjct: 279 -LREGYRRRRDLLAGGLRAM-GLRVYVPEGTYFLMAELPGW-----DAFRLVEEA----- 326 Query: 423 YFLDKFQVAMVPGDAF----GDDSCIRISYATSLDVLQAAVEKI 462 +VA++P AF R ++ + + L A+E++ Sbjct: 327 ------RVALIPASAFYLEDPPKDLFRFAFCKTEEELHLALERL 364 >1YIY-A nrPDB Length = 429 Score = 137 bits (344), Expect = 1e-32, Method: Compositional matrix adjust. Identities = 114/440 (25%), Positives = 194/440 (44%), Gaps = 59/440 (13%) Query: 62 ETLSSSVDMSLSPRVQSLKPSKTMVITDLAATLVQSGVPVIRLAAGEPDFDTPKVVAEAG 121 ET+ + D L R Q S + LAA + L G PD+ PK A Sbjct: 7 ETMHNKFD--LPKRYQGSTKSVWVEYIQLAAQYKP-----LNLGQGFPDYHAPKYALNAL 59 Query: 122 INAIREG---FTRYTLNAGITELREAICRKLKEENGLSYAP-DQILVSNGAKQSLLQAVL 177 A +YT G L +A+ + + + P ++LV+ GA ++L + Sbjct: 60 AAAANSPDPLANQYTRGFGHPRLVQALSKLYSQLVDRTINPMTEVLVTVGAYEALYATIQ 119 Query: 178 AVCSPGDEVIIPAPYWVSYTEQARLADATPVVIPTK--------ISNNFLLDPKDLESKL 229 GDEVII P++ Y + A P IP K S +++LD +LE+ Sbjct: 120 GHVDEGDEVIIIEPFFDCYEPMVKAAGGIPRFIPLKPNKTGGTISSADWVLDNNELEALF 179 Query: 230 TEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFA 289 EK++++I+ +P NP G V ++ LE +A + K +L +SDE+YEH+++ P H Sbjct: 180 NEKTKMIIINTPHNPLGKVMDRAELEVVANLCKKW-NVLCVSDEVYEHMVFEPFEHIRIC 238 Query: 290 SLPDMYERTLTVNGFSKAFAMTGWRLGYLAGP-----------KHIVAAC-SKLQGQVSS 337 +LP M+ERT+T+ K F++TGW++G+ GP ++ V C + +Q ++ Sbjct: 239 TLPGMWERTITIGSAGKTFSLTGWKIGWAYGPEALLKNLQMVHQNCVYTCATPIQEAIAV 298 Query: 338 GASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLGDIKGVKISEPQGAFYLF 397 G + ++ GE +A +RD++ L ++ G+ + PQG +++ Sbjct: 299 GFETELKRLKSPECYFNSISGELMA--------KRDYMASFLAEV-GMNPTVPQGGYFMV 349 Query: 398 IDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVAMV-------------PGDAFGDDSCI 444 D+S S L ++ + Y K+ V P G+D + Sbjct: 350 ADWS----SLDSKVDLTQETDARKDYRFTKWMTKSVGLQGIPPSAFYSEPNKHLGED-FV 404 Query: 445 RISYATSLDVLQAAVEKIRK 464 R + + LQ A E +RK Sbjct: 405 RYCFFKKDENLQKAAEILRK 424 >2X5D-A nrPDB Length = 412 Score = 135 bits (341), Expect = 3e-32, Method: Compositional matrix adjust. Identities = 106/396 (26%), Positives = 181/396 (45%), Gaps = 23/396 (5%) Query: 75 RVQSLKPSKTMVITDLAATLVQSGVPVIRLAAGEPDFDTP-KVVAEAGINAIREGFTRYT 133 R+ L P + +L + G +I L+ G PD TP +V + A RE Y+ Sbjct: 13 RIDRLPPYVFNITAELKMAARRRGEDIIDLSMGNPDGPTPPHIVEKLCTVAQREDTHGYS 72 Query: 134 LNAGITELREAICRKLKEENGLSYAPD-QILVSNGAKQSLLQAVLAVCSPGDEVIIPAPY 192 + GI LR AI ++ + P+ + +V+ G+K+ L +LA GD +++P P Sbjct: 73 TSRGIPRLRRAISHWYRDRYDVQIDPESEAIVTIGSKEGLAHLMLATLDHGDTILVPNPS 132 Query: 193 WVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTE---KSRLLILCSPSNPTGSVY 249 + + A +A A +P +F +LE + E K R++IL PSNPT Sbjct: 133 YPIHIYGAVIAGAQVRSVPLVPGIDFF---NELERAIRESIPKPRMMILGFPSNPTAQCV 189 Query: 250 PKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFA 309 E + +AK ++V+ D Y I+Y S +P + + SK++ Sbjct: 190 ELDFFERVV-ALAKQYDVMVVHDLAYADIVYDGWKAPSIMQVPGAKDIAVEFFTLSKSYN 248 Query: 310 MTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYR 369 M GWR+G++ G +V+A ++++ G + Q A +AAL + + V ++ + Y+ Sbjct: 249 MAGWRIGFMVGNPELVSALARIKSYHDYGTFTPLQVAAIAAL---EGDQQCVRDIARQYQ 305 Query: 370 ERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQ 429 +RRD LVK L + G + P+ + Y++ Y S A L + Sbjct: 306 QRRDVLVKGLRE-AGWMVENPKASMYVWAKIPEPYAHLG--------SLEFAKKLLQDAK 356 Query: 430 VAMVPGDAFGD--DSCIRISYATSLDVLQAAVEKIR 463 V++ PG FGD D +R + + D L+ AV I+ Sbjct: 357 VSVSPGIGFGDYGDDHVRFALIENRDRLRQAVRGIK 392 >2GB3-A nrPDB Length = 409 Score = 135 bits (341), Expect = 3e-32, Method: Compositional matrix adjust. Identities = 94/328 (28%), Positives = 168/328 (51%), Gaps = 15/328 (4%) Query: 72 LSPRVQSLKPSKTMVITDLAATLVQSGVPVIRLAAGEPDFDTPKVVAEAGINAIREGFTR 131 S RV + S + A + GV + L G+PD TP+V E I + Sbjct: 16 FSDRVLLTEESPIRKLVPFAEMAKKRGVRIHHLNIGQPDLKTPEVFFER-IYENKPEVVY 74 Query: 132 YTLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAP 191 Y+ +AGI ELREA K + P+ +LV+NG +++L + + +PGDE+++ P Sbjct: 75 YSHSAGIWELREAFASYYKRRQRVDVKPENVLVTNGGSEAILFSFAVIANPGDEILVLEP 134 Query: 192 YWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPK 251 ++ +Y A++A + + ++ F + P++LES + E+++ ++L +P NPTG VY K Sbjct: 135 FYANYNAFAKIAGVKLIPVTRRMEEGFAI-PQNLESFINERTKGIVLSNPCNPTGVVYGK 193 Query: 252 SLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFAS-LPDMYERTLTVNGFSKAFAM 310 + + I +H L++ DE+Y I++ FAS L ++ + ++ SK F+ Sbjct: 194 DEMRYLVEIAERHGLFLIV-DEVYSEIVF----RGEFASALSIESDKVVVIDSVSKKFSA 248 Query: 311 TGWRLGYL-AGPKHIVAACSKL-QGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAY 368 G R+G L + +++ KL QG+++ + Q V L L + + V E Y Sbjct: 249 CGARVGCLITRNEELISHAMKLAQGRLA--PPLLEQIGSVGLLNLDDSFFDFVRE---TY 303 Query: 369 RERRDFLVKSLGDIKGVKISEPQGAFYL 396 RER + ++K L + + ++P GAFY+ Sbjct: 304 RERVETVLKKLEEHGLKRFTKPSGAFYI 331 >5YHV-A nrPDB Length = 394 Score = 125 bits (315), Expect = 3e-29, Method: Compositional matrix adjust. Identities = 109/370 (29%), Positives = 170/370 (45%), Gaps = 21/370 (5%) Query: 101 VIRLAAGEPDFDTPKVVAEAGINAIREGFTRYTLNAGITELREAICRKLKEENGLSYAPD 160 ++ L+AG+P P+ V A A+ Y++ GI ELR+AI + +G++ PD Sbjct: 39 LVNLSAGQPSAGAPEPVRAAAAAALHLNQLGYSVALGIPELRDAIAADYQRRHGITVEPD 98 Query: 161 QILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNNFLL 220 ++++ G+ L A LA GD V + +P + Y V IP F Sbjct: 99 AVVITTGSSGGFLLAFLACFDAGDRVAMASPGYPCYRNILSALGCEVVEIPCGPQTRFQP 158 Query: 221 DPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARII-AKHPRLLVLSDEIYEHII 279 + L +++ R +++ SP+NPTG+V P L IA A RL +SDE+Y ++ Sbjct: 159 TAQML-AEIDPPLRGVVVASPANPTGTVIPPEELAAIASWCDASDVRL--ISDEVYHGLV 215 Query: 280 YAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGA 339 Y A TS A + VN FSK +AMTGWRLG+L P + A L G + Sbjct: 216 YQGAPQTSCAW--QTSRNAVVVNSFSKYYAMTGWRLGWLLVPTVLRRAVDCLTGNFTICP 273 Query: 340 SSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLGDIKGVKISEPQGAFYLFID 399 ++Q A V+A +A E + +Y R L+ L I +++ GAFY++ D Sbjct: 274 PVLSQIAAVSAF-TPEATAEADGNL-ASYAINRSLLLDGLRRIGIDRLAPTDGAFYVYAD 331 Query: 400 FSAYYGSEAEGFGLINDSSSLALYFLDKFQVAMVPG---DAFGDDSCIRISYATSLDVLQ 456 S + +DS + L VA+ PG D S +RIS+A ++ Sbjct: 332 VSDF----------TSDSLAFCSKLLADTGVAIAPGIDFDTARGGSFVRISFAGPSGDIE 381 Query: 457 AAVEKIRKAL 466 A+ +I L Sbjct: 382 EALRRIGSWL 391 >3H14-A nrPDB Length = 391 Score = 123 bits (309), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 103/393 (26%), Positives = 177/393 (45%), Gaps = 25/393 (6%) Query: 78 SLKPSKTMVITDLAATLVQSGVPVIRLAAGEPDFDTPKVVAEAGINAIREGFTRYTLNAG 137 ++ P M + + A ++G +I + G+P P+ EA ++ YT+ G Sbjct: 10 AVDPFIVMDVMEAARRAEEAGRRIIHMEVGQPGTGAPRGAVEALAKSLETDALGYTVALG 69 Query: 138 ITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYT 197 + LR+ I R E G+ P +++++ G+ L A A+ GD V I AP + SY Sbjct: 70 LPALRQRIARLYGEWYGVDLDPGRVVITPGSSGGFLLAFTALFDSGDRVGIGAPGYPSYR 129 Query: 198 EQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEI 257 + R PV +PT N P D L++ SP+NPTG++ + + + Sbjct: 130 QILRALGLVPVDLPTAPENRLQPVPADFAGLDLAG---LMVASPANPTGTMLDHAAMGAL 186 Query: 258 ARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGY 317 A+ +SDEIY I Y T+ ++ + +N FSK F+MTGWR+G+ Sbjct: 187 IE-AAQAQGASFISDEIYHGIEYEAKAVTAL----ELTDECYVINSFSKYFSMTGWRVGW 241 Query: 318 LAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVK 377 + P+ V ++ + A +Q VAAL E A + Y+ R +++ Sbjct: 242 MVVPEDQVRVVERIAQNMFICAPHASQ---VAALAALDCDAELQANL-DVYKANRKLMLE 297 Query: 378 SLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVAMVPGDA 437 L +I+ P GAFY++ D S L +DS + A L+K VA+ PG Sbjct: 298 RLPKAGFTRIAPPDGAFYVYADVS----------DLTDDSRAFAAEILEKAGVAVTPGLD 347 Query: 438 FGDD---SCIRISYATSLDVLQAAVEKIRKALE 467 F + +R SYA + ++ ++++ ++ Sbjct: 348 FDPERGAGTLRFSYARATADIEEGLDRLEAFMQ 380 >1BW0-A nrPDB Length = 416 Score = 119 bits (299), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 103/390 (26%), Positives = 173/390 (44%), Gaps = 42/390 (10%) Query: 100 PVIRLAAGEPDFDTPKVVAEAGINAIREGFTRYTLNA-----GITELREAICRKL----- 149 P+I+L+ G+P D + + A I ++E N G E REA+ Sbjct: 34 PIIKLSVGDPTLDKNLLTSAAQIKKLKEAIDSQECNGYFPTVGSPEAREAVATWWRNSFV 93 Query: 150 -KEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADATPV 208 KEE + D +++ +G +L A+ A+C GD ++P P + Y + Sbjct: 94 HKEELKSTIVKDNVVLCSGGSHGILMAITAICDAGDYALVPQPGFPHYETVCKAYGIGMH 153 Query: 209 VIPTKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLL 268 + N++ D ++ +K++LLI+ +PSNP GS + + +E+I R +A+ RL Sbjct: 154 FYNCRPENDWEADLDEIRRLKDDKTKLLIVTNPSNPCGSNFSRKHVEDIVR-LAEELRLP 212 Query: 269 VLSDEIYEHIIYA----PATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYL------ 318 + SDEIY +++ AT TS A R + + G +K + GWRLG+L Sbjct: 213 LFSDEIYAGMVFKGKDPNATFTSVADFETTVPRVI-LGGTAKNLVVPGWRLGWLLYVDPH 271 Query: 319 -AGPKHIVAACSKLQGQVSSGASSIAQKAGVAALG--LGKAGGETVAEMVKAYRERRDFL 375 GP + K G + G ++ Q AALG L E + ++V E +L Sbjct: 272 GNGPSFLEGL--KRVGMLVCGPCTVVQ----AALGEALLNTPQEHLDQIVAKIEESAMYL 325 Query: 376 VKSLGDIKGVKISEPQGAFYLF--IDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVAMV 433 +G+ G+ + P+GA YL ID Y I L++ V ++ Sbjct: 326 YNHIGECIGLAPTMPRGAMYLMSRIDLEKYRD--------IKTDVEFFEKLLEEENVQVL 377 Query: 434 PGDAFGDDSCIRISYATSLDVLQAAVEKIR 463 PG F R++ ++V + AVE+I+ Sbjct: 378 PGTIFHAPGFTRLTTTRPVEVYREAVERIK 407 >3ELE-A nrPDB Length = 398 Score = 117 bits (292), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 109/391 (27%), Positives = 176/391 (45%), Gaps = 60/391 (15%) Query: 101 VIRLAAGEPDFDTPKVVAEAGINAIREGFTRY--------TLNAGITELREAICRKLKEE 152 V + G P P++V + I+E T Y T G E R AI L Sbjct: 37 VYDFSIGNPSIPAPQIVNDT----IKELVTDYDSVALHGYTSAQGDVETRAAIAEFLNNT 92 Query: 153 NGLSYAPDQILVSNGAKQSLLQAVLAVCSPG-DEVIIPAPYWVSYTEQARLADATPVVIP 211 +G + D + ++ GA SL A+ S DE I APY+ Y A A V +P Sbjct: 93 HGTHFNADNLYMTMGAAASLSICFRALTSDAYDEFITIAPYFPEYKVFVNAAGARLVEVP 152 Query: 212 TKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPR----- 266 + +F +D LE ++ +R +I+ SP+NP+G+VY + +++++ ++ K + Sbjct: 153 AD-TEHFQIDFDALEERINAHTRGVIINSPNNPSGTVYSEETIKKLSDLLEKKSKEIGRP 211 Query: 267 LLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHI-- 324 + +++DE Y I+Y F + Y+ TL +SK+ ++ G R+GY+ P + Sbjct: 212 IFIIADEPYREIVY-DGIKVPFVT--KYYDNTLVCYSYSKSLSLPGERIGYVLVPDEVYD 268 Query: 325 -----VAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSL 379 A C + A S+ QK V G A G+ + AY+E RD L + L Sbjct: 269 KAELYAAVCGAGRALGYVCAPSLFQKMIVKCQG---ATGD-----INAYKENRDLLYEGL 320 Query: 380 GDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQ---VAMVPGD 436 I G +P GAFY+F+ L +DS++ F +K + V +V D Sbjct: 321 TRI-GYHCFKPDGAFYMFVK------------ALEDDSNA----FCEKAKEEDVLIVAAD 363 Query: 437 AFGDDSCIRISYATSLDVLQA---AVEKIRK 464 FG +RISY ++++ A EKI K Sbjct: 364 GFGCPGWVRISYCVDREMIKHSMPAFEKIYK 394 >4IX8-A nrPDB Length = 444 Score = 106 bits (265), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 95/393 (24%), Positives = 177/393 (45%), Gaps = 49/393 (12%) Query: 102 IRLAAGEPDFD----TPKVVAEAGINAIREG-FTRYTLNAGITELREAI-------CRKL 149 +RL+ G+P D TP +V EA ++ +R G F Y G LR+ + C+ Sbjct: 70 LRLSIGDPTVDGNLKTPDIVTEAMVDVVRSGKFNGYPPTVGADNLRQVVSTYWRRFCQTK 129 Query: 150 KEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADATPVV 209 + L + + +++++G Q+++ A+ A+C+ GD +++ AP S+ + D+ + Sbjct: 130 SRQEALKW--ENVIITSGVSQAIVLALTALCNEGDNILVCAP---SFPHYKSVCDSYGIE 184 Query: 210 IPTKISNNFLLDP-KDLESKL-------TEKSRLLILCSPSNPTGSVYPKSLLEEIARII 261 + LDP K E L ++ ++ +PSNP GS + ++ + +I Sbjct: 185 -----CRYYYLDPSKSWECDLRAAAGMVDSHTKAFVIINPSNPCGSNFSRAHVSDIIDFC 239 Query: 262 AKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGY--LA 319 +H ++ ++SDEIY ++ TS A R L + G +K GWR+G+ L Sbjct: 240 QQH-QIPLISDEIYAEMVLNNGIFTSVADFDTNVPR-LILGGTAKYQVCPGWRVGWSILI 297 Query: 320 GPKHIV---AACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLV 376 P ++ A + Q+ +G +SI Q+A A L K E +V Sbjct: 298 DPMNVAGDWAVGMERLTQLIAGVNSICQEA--IARTLLKCPTECTEHIVTQLEAGAKVYA 355 Query: 377 KSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALY--FLDKFQVAMVP 434 + L G+ + PQ + ++ + + Y + + S + Y LD+ V ++P Sbjct: 356 RLLEHDIGISMEAPQASMFVMLKLNLSYFQDLK--------SDMEFYEKLLDEENVQVLP 407 Query: 435 GDAFGDDSCIRISYATSLDVLQAAVEKIRKALE 467 G+ FG +R + + VL AV++I + E Sbjct: 408 GEIFGMSGFLRATVSRPSAVLNEAVDRIIEFCE 440 >3B46-A nrPDB Length = 447 Score = 105 bits (261), Expect = 5e-23, Method: Compositional matrix adjust. Identities = 77/327 (23%), Positives = 156/327 (47%), Gaps = 27/327 (8%) Query: 160 DQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADATPVVIP-------- 211 + + V+ GA + +L ++ + + GDEVI+ P++ Y L V +P Sbjct: 119 ENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELD 178 Query: 212 --TKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLV 269 + +D + E +T K++ +I+ +P NP G V+ + L + I KH +++ Sbjct: 179 QRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKH-NVVI 237 Query: 270 LSDEIYEHIIYAPATHTSFASL-PDMYERTLTVNGFSKAFAMTGWRLGY-LAGPKHIVAA 327 +SDE+YEH+ Y + T A+L P++ + TLTV K+FA TGWR+G+ L+ +++ Sbjct: 238 ISDEVYEHL-YFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSY 296 Query: 328 CSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLGDIKGVKI 387 +K ++ + S Q+A ++ G +M + Y + + S+ D G+ Sbjct: 297 AAKAHTRICFASPSPLQEACANSINDALKIG-YFEKMRQEYINKFK-IFTSIFDELGLPY 354 Query: 388 SEPQGAFYLFIDFSAYYGSEAEGF--GLINDSSSLAL--YFLDKFQVAMVPGDAF----- 438 + P+G +++ +DFS E + ++N + + +++ V +P F Sbjct: 355 TAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAIPPTEFYIKEH 414 Query: 439 --GDDSCIRISYATSLDVLQAAVEKIR 463 ++ +R + L+ AVE+++ Sbjct: 415 EKAAENLLRFAVCKDDAYLENAVERLK 441 >3ASB-A nrPDB Length = 400 Score = 103 bits (257), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 115/419 (27%), Positives = 181/419 (43%), Gaps = 53/419 (12%) Query: 70 MSLSPRVQSLKPSKTMVITDLAATLVQSGVP-----VIRLAAGEPDFDTPKVVAEAGINA 124 M +P SL +K + DL + Q + VI L+ G+ VAEA ++ Sbjct: 1 MKRNPHFVSL--TKNYLFADLQKRVAQFRLENPQHTVINLSIGDTTQPLNASVAEAFASS 58 Query: 125 IRE-----GFTRYTLNAGITELREAICRKLKEENGLSYA-PDQILVSNGAKQSLLQAVLA 178 I Y + G+ LR+ KL E+ + +I +S+GAK L + +L+ Sbjct: 59 IARLSSPTTCRGYGPDFGLPALRQ----KLSEDFYRGFVDAKEIFISDGAKVDLFR-LLS 113 Query: 179 VCSPGDEVIIPAPYWVSYTEQARLADATPVV-IPTKISNNFLLD-PKDLESKLTEKSRLL 236 P V I P + +Y + ARL A ++ +P N F + P+D + L Sbjct: 114 FFGPNQTVAIQDPSYPAYLDIARLTGAKEIIALPCLQENAFFPEFPEDTHIDI------L 167 Query: 237 ILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYE 296 LCSP+NPTG+V K L I +H +L+L D Y I P+ S +PD Sbjct: 168 CLCSPNNPTGTVLNKDQLRAIVHYAIEH-EILILFDAAYSTFISDPSLPKSIFEIPDARF 226 Query: 297 RTLTVNGFSKAFAMTGWRLGYLAGPKHIVAA--------CSKLQGQVSSGASSIAQKAGV 348 + +N FSK G RLG+ P+ + A + +GAS AQ+AGV Sbjct: 227 CAIEINSFSKPLGFAGIRLGWTVIPQELTYADGHFVIQDWERFLSTTFNGASIPAQEAGV 286 Query: 349 AALGLGKAGGETVAEMVKAYRERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEA 408 A L + E + YRE D L K+L G ++ + A YL++ + S+ Sbjct: 287 AGLSILPQ-----LEAIHYYRENSDLLRKALL-ATGFEVFGGEHAPYLWVKPTQANISDR 340 Query: 409 EGFGLINDSSSLALYFLDKFQVAMVPGDAFGDDSC--IRISYATSLDVLQAAVEKIRKA 465 + F +FL ++ +A+ PG FG +R S + + AA E+++ A Sbjct: 341 DLFD----------FFLREYHIAITPGIGFGRSGSGFVRFSSLGKREDILAACERLQMA 389 >3T32-A nrPDB Length = 383 Score = 102 bits (253), Expect = 5e-22, Method: Compositional matrix adjust. Identities = 95/388 (24%), Positives = 168/388 (43%), Gaps = 53/388 (13%) Query: 101 VIRLAAGEPDFDTPKVVAEAGINAIREGFTRYTL---NAGITELREAICRKLKEENGLSY 157 +I + DF+ P+ + A I YTL N G + IC K++ Sbjct: 26 LIHAWIADMDFEVPQPIQTALKKRIEHPIFGYTLPPENIG-----DIICNWTKKQYNWDI 80 Query: 158 APDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNN 217 + I+ S G +L ++ A + V++ P + + E + V P + N+ Sbjct: 81 QKEWIVFSAGIVPALSTSIQAFTKENESVLVQPPIYPPFFEMVTTNNRQLCVSPLQKQND 140 Query: 218 -FLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYE 276 + +D + LE + + +L++LCSP NP G V+ K L ++ + K+ ++V++DEI+ Sbjct: 141 TYAIDFEHLEKQFQQGVKLMLLCSPHNPIGRVWKKEELTKLGSLCTKY-NVIVVADEIHS 199 Query: 277 HIIYAPATHTSFASL-PDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQV 335 IIYA THT FASL ++ RT+T SK F + G + + P ++ Sbjct: 200 DIIYADHTHTPFASLSEELAARTITCMAPSKTFNIAGLQASIIIIPNE----------KL 249 Query: 336 SSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFL--------------VKSLGD 381 +SI + G L + M AY E D+L + + D Sbjct: 250 RQAFTSIQYRQGFHGLNIF-----AYTAMQSAYTECNDWLNEIRFYIEDNAKFACEYIKD 304 Query: 382 -IKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVAMVPGDAF-- 438 I + + +P+G+F L+ID SA S+ E L+ +K ++ + PG+ + Sbjct: 305 HIPTLSVMKPEGSFLLWIDCSALNLSQDERTKLLE----------EKGKIIVEPGEKYGL 354 Query: 439 GDDSCIRISYATSLDVLQAAVEKIRKAL 466 G + I I+ VL+ + ++R Sbjct: 355 GGEEHIGINIGCPRSVLEEILNRLRHTF 382 >2O1B-A nrPDB Length = 404 Score = 99.8 bits (247), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 91/394 (23%), Positives = 172/394 (43%), Gaps = 38/394 (9%) Query: 71 SLSPRVQSLKPSKTMVITD------LAATLVQSGVPVIRLAAGEPDFDTPKVVAEAGINA 124 L PR + +K I D + + +P+I +A G PD TP+ + I+ Sbjct: 13 GLVPRGSHMISNKLANIPDSYFGKTMGRKIEHGPLPLINMAVGIPDGPTPQGI----IDH 68 Query: 125 IREGFT-----RYTLNAGITELREAICRKLKEENGLSY-APDQILVSNGAKQSLLQAVLA 178 ++ T +Y G ++AI + + ++ D++ + G K L+ Sbjct: 69 FQKALTIPENQKYGAFHGKEAFKQAIVDFYQRQYNVTLDKEDEVCILYGTKNGLVAVPTC 128 Query: 179 VCSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLIL 238 V +PGD V++P P + Y LAD PV + + ++L D ++S++ +K++L+ L Sbjct: 129 VINPGDYVLLPDPGYTDYLAGVLLADGKPVPLNLE-PPHYLPDWSKVDSQIIDKTKLIYL 187 Query: 239 CSPSNPTGSVYPKSLLEE-IARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYER 297 P+NPTGS K + +E IA+ + ++ D Y + A + S + + + Sbjct: 188 TYPNNPTGSTATKEVFDEAIAKFKGTDTK--IVHDFAYGAFGFD-AKNPSILASENGKDV 244 Query: 298 TLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAG 357 + + SK + M+G+R+G+ G K ++ A K Q ++G Q A + AL Sbjct: 245 AIEIYSLSKGYNMSGFRVGFAVGNKDMIQALKKYQTHTNAGMFGALQDAAIYAL---NHY 301 Query: 358 GETVAEMVKAYRERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDS 417 + + E ++ RRD L + +G Y++++ Y DS Sbjct: 302 DDFLEEQSNVFKTRRDRFEAMLAKAD-LPFVHAKGGIYVWLETPPGY-----------DS 349 Query: 418 SSLALYFLDKFQVAMVPGDAFGDDS--CIRISYA 449 + + + + + PG FG++ +RIS A Sbjct: 350 EQFEQFLVQEKSILVAPGKPFGENGNRYVRISLA 383 >4DQ6-A nrPDB Length = 391 Score = 98.6 bits (244), Expect = 5e-21, Method: Compositional matrix adjust. Identities = 89/375 (23%), Positives = 175/375 (46%), Gaps = 33/375 (8%) Query: 104 LAAGEPDFDTPKVVAEAGINAIREGFTRYTLNAGITELREAICRKLKEENGLSYAPDQIL 163 + + DF + ++ N + + YT E+I L + + ++ Sbjct: 37 MWVADMDFKAAPCIIDSLKNRLEQEIYGYTTRPD--SYNESIVNWLYRRHNWKIKSEWLI 94 Query: 164 VSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADATPVVIP-TKISN-NFLLD 221 S G ++ + + D+++I P + + + + ++ P K+ N N+++D Sbjct: 95 YSPGVIPAISLLINELTKANDKIMIQEPVYSPFNSVVKNNNRELIISPLQKLENGNYIMD 154 Query: 222 PKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYA 281 +D+E+K+ + +L ILC+P NP G V+ K L+++ I KH + ++SDEI+ II Sbjct: 155 YEDIENKIKD-VKLFILCNPHNPVGRVWTKDELKKLGDICLKH-NVKIISDEIHSDIILK 212 Query: 282 PATHTSFASLPDMYER-TLTVNGFSKAFAMTGWRLGYLAGP-----KHIVAACSKLQGQV 335 H AS+ +E+ T+T +K F + G + Y+ P K + A +++ + Sbjct: 213 KHKHIPMASISKEFEKNTITCMAPTKTFNIAGLQSSYVVLPDEKDYKLLDDAFTRIDIKR 272 Query: 336 SSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERR-DFLVKSLG-DIKGVKISEPQGA 393 ++ S +A +A GE+ E Y E DF +K + ++ +K+ +P+G Sbjct: 273 NNCFSLVATEASY-------NNGESWLESFLEYLESNIDFAIKYINENMPKLKVRKPEGT 325 Query: 394 FYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVAMVPGDAF--GDDSCIRISYATS 451 + L++DFSA S+ E L + K +VA+ G++F G RI+ A Sbjct: 326 YLLWVDFSALGLSDEE----------LESILVQKGKVALNQGNSFGIGGSGYQRINLACP 375 Query: 452 LDVLQAAVEKIRKAL 466 +L+ A+ +I+ A+ Sbjct: 376 RSMLEEALIRIKNAI 390 >5Z0Q-C nrPDB Length = 389 Score = 98.6 bits (244), Expect = 5e-21, Method: Compositional matrix adjust. Identities = 88/362 (24%), Positives = 165/362 (45%), Gaps = 25/362 (6%) Query: 112 DTPKVVAEAGINAIREGFTRYTLNAGITE--LREAICRKLKEENGLSYAPDQILVSNGAK 169 DT A+ I+A+++ + G+T L E +++ G P+ ++ G Sbjct: 42 DTDFRAADCIIDALQQRVQQGVFGYGVTSEALAEVAIERMESRFGWKIQPEWLVFLPGVV 101 Query: 170 QSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNN-FLLDPKDLESK 228 + AV A + P + + +LA + ++ ++LD E + Sbjct: 102 TGINIAVRAFTEAHQSTVSATPIYPPFFLAPKLAGRQHLSAALRLEQQRWVLDLDSHEDR 161 Query: 229 LTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPAT-HTS 287 ++ +LL+LC+P NP G+VY + LE R +H LLV SDEI+ ++ P H Sbjct: 162 MSGNEKLLLLCNPHNPGGTVYRRKELEAQLRFAQRHD-LLVCSDEIHCDLVLEPGVQHIP 220 Query: 288 FASL-PDMYERTLTVNGFSKAFAMTGW--RLGYLAGPKHIVAACSKLQGQVSSGASSIAQ 344 FASL D +R++T+ SK+F + G L + P+ + A ++++ + +A Sbjct: 221 FASLSDDAAQRSITLMSPSKSFNIAGLGASLAVIPNPE-LRARFNRMRKGMVPDVDVLAY 279 Query: 345 KAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYY 404 A AA + G + + R RD L + + + G+ + P+ +F +ID Sbjct: 280 VAASAAW---REGQPWLDAQLDYLRANRDMLAQHVNRLPGLSMVTPEASFLGWID----- 331 Query: 405 GSEAEGFGLINDSSSLALYFLDKFQVAMVPGDAFGDDSCIRISYATSLDVLQAAVEKIRK 464 A G G+ + AL+F +K + G FG+D +R ++ +L+ A++++ + Sbjct: 332 ---ASGLGVADP----ALFF-EKHGLGFSSGRDFGNDRFVRFNFGCPRQLLEEALQRMTR 383 Query: 465 AL 466 AL Sbjct: 384 AL 385 >3B1C-A nrPDB Length = 392 Score = 97.4 bits (241), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 74/287 (25%), Positives = 137/287 (47%), Gaps = 6/287 (2%) Query: 140 ELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQ 199 EL +A+ K E+ S+ + I+ G ++ A+ A G+ V+I +P + + Sbjct: 70 ELLQAVLDWEKSEHQYSFDKEDIVFVEGVVPAISIAIQAFTKEGEAVLINSPVYPPFARS 129 Query: 200 ARLADATPVVIPTKISNN-FLLDPKDLESKLTEKS-RLLILCSPSNPTGSVYPKSLLEEI 257 RL + V K N F +D + LE+ + E +L +LC+P NP G V+ + +LE+I Sbjct: 130 VRLNNRKLVSNSLKEENGLFQIDFEQLENDIVENDVKLYLLCNPHNPGGRVWEREVLEQI 189 Query: 258 ARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASL-PDMYERTLTVNGFSKAFAMTGWRLG 316 + KH +LV SDEI++ + H SF ++ PD + L ++ +K F + G + Sbjct: 190 GHLCQKHHVILV-SDEIHQDLTLFGHEHVSFNTVSPDFKDFALVLSSATKTFNIAGTKNS 248 Query: 317 YLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLV 376 Y + A K Q Q+ + ++ +A + G + + E F V Sbjct: 249 YAIIENPTLCAQFKHQ-QLVNNHHEVSSLGYIATETAYRYGKPWLVALKAVLEENIQFAV 307 Query: 377 KSLG-DIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLAL 422 + + +K+ +PQG + +++DFS Y ++ F L++D + + L Sbjct: 308 EYFAQEAPRLKVMKPQGTYLIWLDFSDYGLTDDALFTLLHDQAKVIL 354 >2DOU-A nrPDB Length = 376 Score = 95.5 bits (236), Expect = 5e-20, Method: Compositional matrix adjust. Identities = 102/392 (26%), Positives = 177/392 (45%), Gaps = 25/392 (6%) Query: 80 KPSKTMVITDLAATLVQSGVPVIRLAAGEPDFDTPKVVAEAGINAIREGFTR-YTLNAGI 138 +PS +V+ + + GV +I L+ G D P+ +A A+ + T Y L + Sbjct: 6 EPSVFLVVDEAKRKARERGVGLIDLSIGSTDLPPPEAPLKALAEALNDPTTYGYCLKSCT 65 Query: 139 TELREAICRKLKEENGLSYAPD-QILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYT 197 E R + G+ P + L G+++ L +LA+ P D +++P + SY Sbjct: 66 LPFLEEAARWYEGRYGVGLDPRREALALIGSQEGLAHLLLALTEPEDLLLLPEVAYPSYF 125 Query: 198 EQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEI 257 AR+A +IP + + L D K + + ++++L+L P+NPTG+V EE Sbjct: 126 GAARVASLRTFLIPLR--EDGLADLKAVPEGVWREAKVLLLNYPNNPTGAVADWGYFEEA 183 Query: 258 ARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGY 317 + KH L ++ D Y +Y + A LP ER + + SK++ + G+RLG+ Sbjct: 184 LGLARKH-GLWLIHDNPYVDQVYEGEAPSPLA-LPGAKERVVELFSLSKSYNLAGFRLGF 241 Query: 318 LAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVK 377 G + +A +++G + + + GV AL K E V + YRER + + Sbjct: 242 ALGSEEALARLERVKGVIDFNQYAGVLRMGVEAL---KTPKEVVRGYARVYRERALGMAE 298 Query: 378 SLGDIKGV-KISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDK-FQVAMVPG 435 +L KGV + P+ YL +G EG D L +++ +A G Sbjct: 299 AL---KGVLSLLPPRATMYL-------WGRLPEGV----DDLEFGLRLVERGVALAPGRG 344 Query: 436 DAFGDDSCIRISYATSLDVLQAAVEKIRKALE 467 G +RI+ L+ L A ++IR+AL+ Sbjct: 345 FGPGGKGFVRIALVRPLEELLEAAKRIREALD 376 >3L8A-A nrPDB Length = 421 Score = 92.4 bits (228), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 92/374 (24%), Positives = 170/374 (45%), Gaps = 33/374 (8%) Query: 101 VIRLAAGEPDFDTPKVVAEAGINAIREGFTRYTLNAGITELREAICRKLKEENGLSYAPD 160 ++++ + DF + EA IN RE Y N +L +A+ ++E+ + + Sbjct: 63 LLQMWVADMDFLPVPEIKEAIINYGREHIFGY--NYFNDDLYQAVIDWERKEHDYAVVKE 120 Query: 161 QILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKISN-NFL 219 IL +G ++ A+ A GD V+I +P + + RL D V +I N F Sbjct: 121 DILFIDGVVPAISIALQAFSEKGDAVLINSPVYYPFARTIRLNDHRLVENSLQIINGRFE 180 Query: 220 LDPKDLESKLTEKS-RLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHI 278 +D + LE + + + ++ +LCSP NP G V+ L +IA + KH +LV SDEI++ + Sbjct: 181 IDFEQLEKDIIDNNVKIYLLCSPHNPGGRVWDNDDLIKIAELCKKHGVILV-SDEIHQDL 239 Query: 279 IYAPATHTSFASLPDMYER-TLTVNGFSKAFAMTGWRLGYLAGPKHIVAACS------KL 331 TH S +L Y+ T+ ++ +K F +AG K+ A K Sbjct: 240 ALFGNTHHSLNTLDASYKDFTIILSSATKTFN--------IAGTKNSFAIIQNESLRRKF 291 Query: 332 Q-GQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLGDIKGVKISEP 390 Q Q+++ + +A + G + E+ ++K L +K+ EP Sbjct: 292 QYRQLANNQHEVPTVGMIATQAAFQYGKPWLEELKTVIEGNIKLVIKELEAKTKIKVMEP 351 Query: 391 QGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVAMVPGDAFGDDS--CIRISY 448 +G + +++DFSAY ++ + L+ ++ +V + G FG + R++ Sbjct: 352 EGTYLVWLDFSAYAIAQPQ----------LSEKLQNEAKVVLNDGAHFGKEGKYFARLNV 401 Query: 449 ATSLDVLQAAVEKI 462 AT + +Q A+ +I Sbjct: 402 ATPKNTVQEALSRI 415 >1C7O-A nrPDB Length = 399 Score = 91.3 bits (225), Expect = 8e-19, Method: Compositional matrix adjust. Identities = 94/392 (23%), Positives = 173/392 (44%), Gaps = 42/392 (10%) Query: 96 QSGVPVIRLAAGEPDFDTPKVVAEAGINAIREGFTRYTLNAGITELREAICRKLKEENGL 155 + G V+ L+ + +F P + E + E YT E ++ + + +K+ + Sbjct: 28 EVGNEVVPLSVADMEFKNPPELIEGLKKYLDETVLGYT--GPTEEYKKTVKKWMKDRHQW 85 Query: 156 SYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKI- 214 D I+ + G ++ AV PGD VII P V Y + + +I ++ Sbjct: 86 DIQTDWIINTAGVVPAVFNAVREFTKPGDGVIIITP--VYYPFFMAIKNQERKIIECELL 143 Query: 215 --SNNFLLDPKDLESKLTEKS-RLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLS 271 + +D + LE +K+ + L+ CSP NP G V+ K L++I I+ K L++ S Sbjct: 144 EKDGYYTIDFQKLEKLSKDKNNKALLFCSPHNPVGRVWKKDELQKIKDIVLK-SDLMLWS 202 Query: 272 DEIYEHIIYAPATHTSFASLPD-MYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSK 330 DEI+ +I HT F S+ + + ++T+T SK F + G G +I+ Sbjct: 203 DEIHFDLIMPGYEHTVFQSIDEQLADKTITFTAPSKTFNIAG------MGMSNIIIKNPD 256 Query: 331 LQGQVSSGASSIAQKAGVAALGLG--------KAGGETVAEMVKAYRERRDFLVKSLGDI 382 ++ + + + +G+ LG K G+ + +K ++ +VK ++ Sbjct: 257 IRERFTKSRDAT---SGMPFTTLGYKACEICYKECGKWLDGCIKVI-DKNQRIVKDFFEV 312 Query: 383 KGVKISEP--QGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVAMVPGDAFGD 440 +I P +G + +IDF A L D ++ + + K Q+ G FGD Sbjct: 313 NHPEIKAPLIEGTYLQWIDFRA----------LKMDHKAMEEFMIHKAQIFFDEGYIFGD 362 Query: 441 DSC--IRISYATSLDVLQAAVEKIRKALEPLR 470 RI+ A V+Q ++E++ KAL+ L+ Sbjct: 363 GGIGFERINLAAPSSVIQESLERLNKALKDLK 394 >3FDB-A nrPDB Length = 377 Score = 90.9 bits (224), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 100/402 (24%), Positives = 174/402 (43%), Gaps = 42/402 (10%) Query: 74 PRVQSLKPSKTMVITDLAATLVQSGVPVIRLAAGEPDFDTPKVVAEAGINAI-REGFTRY 132 P ++ L+ TM T + G V+ L E DF T V +A +A+ RE F Y Sbjct: 5 PSIEDLRARNTMKWT-------RYGQGVLPLWVAESDFSTCPAVLQAITDAVQREAFG-Y 56 Query: 133 TLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPY 192 + + L +A + G P+ I + L A+ +VI+P P Sbjct: 57 QPDGSL--LSQATAEFYADRYGYQARPEWIFPIPDVVRGLYIAIDHFTPAQSKVIVPTPA 114 Query: 193 WVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKS 252 + + + I N D+E +R ++LC+P NP G V+ Sbjct: 115 YPPFFHLLSATQREGIFIDATGGINL----HDVEKGFQAGARSILLCNPYNPLGMVFAPE 170 Query: 253 LLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERT-LTVNGFSKAFAMT 311 L E+ + ++ VL DEI+ +++ HT A + D +T+ SKA+ + Sbjct: 171 WLNELCDLAHRY-DARVLVDEIHAPLVFD-GQHTVAAGVSDTAASVCITITAPSKAWNIA 228 Query: 312 GWRLGYL--AGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYR 369 G + + + P +L + GAS++ A AA + G + + + V + Sbjct: 229 GLKCAQIIFSNPSD-AEHWQQLSPVIKDGASTLGLIAAEAAY---RYGTDFLNQEVAYLK 284 Query: 370 ERRDFLVKSL-GDIKGVKISEPQGAFYLFIDF--SAYYGSEAEGFGLINDSSSLALYFLD 426 DFL+ + I G KI+ Q + ++IDF + GS +E +F++ Sbjct: 285 NNHDFLLHEIPKRIPGAKITPMQATYLMWIDFRDTTIEGSPSE-------------FFIE 331 Query: 427 KFQVAMVPGDAFGDDSC--IRISYATSLDVLQAAVEKIRKAL 466 K +VAM G FG+D R+++ATS +VL+ A++++ KA+ Sbjct: 332 KAKVAMNDGAWFGEDGTGFCRLNFATSREVLEEAIDRMAKAV 373 >3JTX-A nrPDB Length = 396 Score = 90.1 bits (222), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 82/312 (26%), Positives = 150/312 (48%), Gaps = 20/312 (6%) Query: 98 GVPVIRLAAGEPDFDTPKVVAEAGINAIREGFTRYTLNAGITELREAICRKLKEE-NGLS 156 G+ + L GEP TPKV+ +A ++ E +Y L AG+ ELR+A LK +GL+ Sbjct: 29 GMEAVPLHIGEPKHPTPKVITDALTASLHE-LEKYPLTAGLPELRQACANWLKRRYDGLT 87 Query: 157 Y-APDQILVSNGAKQSLLQAVLAVCSPGDEVIIPA-----PYWVSYTEQARLADATPVVI 210 A ++IL G++++L V V +P + I PA P++ Y E A L + Sbjct: 88 VDADNEILPVLGSREALFSFVQTVLNPVSDGIKPAIVSPNPFYQIY-EGATLLGGGEIHF 146 Query: 211 PTKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVL 270 + +F D + + ++ ++++L+ +CSP+NP+GSV +E+ + K+ ++ Sbjct: 147 ANCPAPSFNPDWRSISEEVWKRTKLVFVCSPNNPSGSVLDLDGWKEVFDLQDKY-GFIIA 205 Query: 271 SDEIYEHIIYAP----ATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVA 326 SDE Y I + + A L ++ L SK + G R G++AG ++ Sbjct: 206 SDECYSEIYFDGNKPLGCLQAAAQLGRSRQKLLMFTSLSKRSNVPGLRSGFVAGDAELLK 265 Query: 327 ACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLGDIKGVK 386 + S S Q+A +AA + V + + Y+E+ + ++ L + VK Sbjct: 266 NFLLYRTYHGSAMSIPVQRASIAAWD----DEQHVIDNRRLYQEKFERVIPILQQVFDVK 321 Query: 387 ISEPQGAFYLFI 398 + P +FY+++ Sbjct: 322 L--PDASFYIWL 331 >3DYD-A nrPDB Length = 427 Score = 87.8 bits (216), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 92/385 (23%), Positives = 165/385 (42%), Gaps = 36/385 (9%) Query: 101 VIRLAAGEP----DFDTPKVVAEAGINAIREG-FTRYTLNAGITELREAICRKLKEENGL 155 +I L+ G+P + T V +A +A+ G + Y + G RE I Sbjct: 56 MISLSIGDPTVFGNLPTDPEVTQAMKDALDSGKYNGYAPSIGFLSSREEIASYYHCPEAP 115 Query: 156 SYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKIS 215 A D IL S G Q++ + + +PG +++P P ++ LA++ + I K+ Sbjct: 116 LEAKDVILTS-GCSQAIDLCLAVLANPGQNILVPRP---GFSLYKTLAES--MGIEVKLY 169 Query: 216 N-----NFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVL 270 N ++ +D K LE + EK+ LI+ +PSNP GSV+ K L++I + A+ + +L Sbjct: 170 NLLPEKSWEIDLKQLEYLIDEKTACLIVNNPSNPCGSVFSKRHLQKILAVAARQ-CVPIL 228 Query: 271 SDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSK 330 +DEIY ++++ + A+L L+ G +K + + GWRLG++ I Sbjct: 229 ADEIYGDMVFSDCKYEPLATLSTDVP-ILSCGGLAKRWLVPGWRLGWIL----IHDRRDI 283 Query: 331 LQGQVSSGASSIAQK--------AGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLGDI 382 ++ G ++Q+ G L + GE + + D +L I Sbjct: 284 FGNEIRDGLVKLSQRILGPCTIVQGALKSILCRTPGEFYHNTLSFLKSNADLCYGALAAI 343 Query: 383 KGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVAMVPGDAFGDDS 442 G++ P GA YL + G E E F + + + V +P F + Sbjct: 344 PGLRPVRPSGAMYLMV------GIEMEHFPEFENDVEFTERLVAEQSVHCLPATCFEYPN 397 Query: 443 CIRISYATSLDVLQAAVEKIRKALE 467 IR+ ++ A +I++ E Sbjct: 398 FIRVVITVPEVMMLEACSRIQEFCE 422 >4R2N-A nrPDB Length = 367 Score = 85.9 bits (211), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 70/243 (28%), Positives = 110/243 (45%), Gaps = 14/243 (5%) Query: 102 IRLAAGEPDFDTPKVVAEAGINAIREGFTRYTLNAGITELREAICRKLKEENGLSYAPDQ 161 I+LA+ E F P A I+ + RY N G +L+ A+ R L G +AP+ Sbjct: 26 IKLASNETVFG-PLPSVRAAIDRATDTVNRYPDN-GCVQLKAALARHL----GPDFAPEH 79 Query: 162 ILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNNFLLD 221 + V G+ Q V S GDEV+ + Y Q R+A A P+ +P + D Sbjct: 80 VAVGCGSVSLCQQLVQVTASVGDEVVFGWRSFELYPPQVRVAGAIPIQVPL---TDHTFD 136 Query: 222 PKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYA 281 + + +T+++RL+ +C+P+NPT +V L + H +L+ DE Y I Sbjct: 137 LYAMLATVTDRTRLIFVCNPNNPTSTVVGPDALARFVEAVPAH--ILIAIDEAYVEYIRD 194 Query: 282 PATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASS 341 S L + + + FSKA+ + G R+GY G ++ A K+ V SS Sbjct: 195 GMRPDSLG-LVRAHNNVVVLRTFSKAYGLAGLRIGYAIGHPDVITALDKV--YVPFTVSS 251 Query: 342 IAQ 344 I Q Sbjct: 252 IGQ 254 >3PDX-A nrPDB Length = 402 Score = 85.5 bits (210), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 92/385 (23%), Positives = 165/385 (42%), Gaps = 36/385 (9%) Query: 101 VIRLAAGEP----DFDTPKVVAEAGINAIREG-FTRYTLNAGITELREAICRKLKEENGL 155 VI L+ G+P + T V +A +A+ G + Y + G RE + Sbjct: 33 VISLSIGDPTVFGNLPTDPEVTQAMKDALDSGKYNGYAPSIGYLSSREEVASYYHCPEAP 92 Query: 156 SYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKIS 215 A D IL S G Q++ + + +PG ++IP P + Y LA++ + I K+ Sbjct: 93 LEAKDVILTS-GCSQAIELCLAVLANPGQNILIPRPGFSLYR---TLAES--MGIEVKLY 146 Query: 216 N-----NFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVL 270 N ++ +D K LES + EK+ L++ +PSNP GSV+ K L++I +A+ + +L Sbjct: 147 NLLPEKSWEIDLKQLESLIDEKTACLVVNNPSNPCGSVFSKRHLQKILA-VAERQCVPIL 205 Query: 271 SDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSK 330 +DEIY ++++ + A+L L+ G +K + + GWRLG++ I Sbjct: 206 ADEIYGDMVFSDCKYEPMATLSTNVP-ILSCGGLAKRWLVPGWRLGWIL----IHDRRDI 260 Query: 331 LQGQVSSGASSIAQK--------AGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLGDI 382 ++ G ++Q+ G L + E + + + D +L I Sbjct: 261 FGNEIRDGLVKLSQRILGPCTIVQGALKSILQRTPQEFYQDTLSFLKSNADLCYGALSAI 320 Query: 383 KGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVAMVPGDAFGDDS 442 G++ P GA YL + G E E F + + + V +P F + Sbjct: 321 PGLQPVRPSGAMYLMV------GIEMEHFPEFENDVEFTERLIAEQSVHCLPATCFEYPN 374 Query: 443 CIRISYATSLDVLQAAVEKIRKALE 467 R+ ++ A +I++ E Sbjct: 375 FFRVVITVPEVMMLEACSRIQEFCE 399 >3NRA-A nrPDB Length = 407 Score = 82.0 bits (201), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 75/278 (26%), Positives = 130/278 (46%), Gaps = 14/278 (5%) Query: 128 GFTRYTLNAGITELREAICRKLKEENGLSY-APDQILVSNGAKQSLLQAVLAVCSPGDEV 186 G YT G +R+ + +L G A D ++++ G + +L AV A + GD+V Sbjct: 70 GVQAYTEYRGDLGIRDLLAPRLAAFTGAPVDARDGLIITPGTQGALFLAVAATVARGDKV 129 Query: 187 IIPAPYWVSYTEQARLADATPVVIPTKIS------NNFLLDPKDLESKLTEKSRLLILCS 240 I P + + + + ++P ++ LD LE +R+ + + Sbjct: 130 AIVQPDYFANRKLVEFFEGE--MVPVQLDYVSADETRAGLDLTGLEEAFKAGARVFLFSN 187 Query: 241 PSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSF-ASLPDMYERTL 299 P+NP G VY + +IA + A++ V++D++Y + YA A++T A E + Sbjct: 188 PNNPAGVVYSAEEIGQIAALAARYG-ATVIADQLYSRLRYAGASYTHLRAEAAVDAENVV 246 Query: 300 TVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGE 359 T+ G SK +++G+RLG G + I+A KLQ VS A+ +Q V +A G Sbjct: 247 TIMGPSKTESLSGYRLGVAFGSRAIIARMEKLQAIVSLRAAGYSQ--AVLRGWFDEAPG- 303 Query: 360 TVAEMVKAYRERRDFLVKSLGDIKGVKISEPQGAFYLF 397 + + + ++ RD L+ L +GV PQ YLF Sbjct: 304 WMEDRIARHQAIRDELLHVLRGCEGVFARTPQAGSYLF 341 >4FL0-A nrPDB Length = 456 Score = 80.9 bits (198), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 87/360 (24%), Positives = 156/360 (43%), Gaps = 47/360 (13%) Query: 127 EGFTRYTLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEV 186 EG+ Y L G LR+AI + L +++ VS+GA+ + + L + S + Sbjct: 103 EGYRGYGLEQGNKTLRKAIAETFYRD--LHVKSNEVFVSDGAQSDISRLQLLLGS-NVTI 159 Query: 187 IIPAPYWVSYTEQARLADATP------------VVIPTKISNNFLLDPKDLESKLTEKSR 234 + P + +Y + + + T V +P +N+F D +T ++ Sbjct: 160 AVQDPTFPAYIDSSVIIGQTGHFHEKTKKYQNVVYMPCGPNNSFFPD-----LAMTPRTD 214 Query: 235 LLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDM 294 ++ CSP+NPTG V + L ++ AK +++ D Y I + S +P Sbjct: 215 VIFFCSPNNPTGYVASRKQLHQLVD-FAKTNGSIIIFDSAYAAFI-EDGSPRSIYEIPGA 272 Query: 295 YERTLTVNGFSKAFAMTGWRLGYLAGPKH--------IVAACSKLQGQVSSGASSIAQKA 346 E + V+ FSK TG RLG+ P I+ ++ +GAS+IAQ Sbjct: 273 REVAIEVSSFSKFAGFTGVRLGWSIIPDELLYSNGFPIINDFHRIVTTSFNGASNIAQAG 332 Query: 347 GVAALGLGKAGGETVAEMVKAYRERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGS 406 G+A L G G + + + Y+E R L+ +L + G+K+ A YL++ F Sbjct: 333 GLACLSSG--GLKEIRSVNNYYKENRKILMDTLVSL-GLKVYGGVNAPYLWVHFKG---- 385 Query: 407 EAEGFGLINDSSSLALYFLDKFQVAMVPGDAF--GDDSCIRISYATSLDVLQAAVEKIRK 464 ++ + + N+ L+ + VPG F G + +RIS D + A ++++ Sbjct: 386 -SKSWDVFNE-------ILENTHIITVPGSGFGPGGEEYLRISGFGRRDHIVEASKRLQN 437 >2ZC0-A nrPDB Length = 407 Score = 79.0 bits (193), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 101/401 (25%), Positives = 174/401 (43%), Gaps = 47/401 (11%) Query: 72 LSPRVQSLKPSKTMVITDLAATLVQSGVPVIRLAAGEPDFDTPKVVAEAGINAI-REGFT 130 L+ R +K S + A+ L + GV +I LAAG+PD P+++ A + I +E Sbjct: 7 LAGRANWIKGSALADVMKKASELQKKGVKLISLAAGDPD---PELIPRAVLGEIAKEVLE 63 Query: 131 R------YTLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGD 184 + YT GI ELRE + LK+ + L +P+ I+++ G +L + PGD Sbjct: 64 KEPKSVMYTPANGIPELREELAAFLKKYDHLEVSPENIVITIGGTGALDLLGRVLIDPGD 123 Query: 185 EVIIPAPYWVSYTEQARLADATPVVIPTKISNNF----LLDPKDLESKLTEKSRLLILCS 240 VI P +++ A +P + N+ LL+ K E K + LI Sbjct: 124 VVITENPSYINTLLAFEQLGAKIEGVP--VDNDGMRVDLLEEKIKELKAKGQKVKLIYTI 181 Query: 241 PS--NPTGSVYP----KSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDM 294 P+ NP G K+LLE IA LL++ D Y + Y +L D Sbjct: 182 PTGQNPMGVTMSMERRKALLE-----IASKYDLLIIEDTAYNFMRYEGGDIVPLKAL-DN 235 Query: 295 YERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLG 354 R + SK TG+R+G++ I+ + + A +I+Q + L G Sbjct: 236 EGRVIVAGTLSKVLG-TGFRIGWIIAEGEILKKVLMQKQPIDFCAPAISQYIALEYLKRG 294 Query: 355 KAGGETVAEMVKAYRERRDFLVKSLGD-IKGVKISEP-QGAFYLFIDFSAYYGSEAEGFG 412 + + Y+E+RD ++K+L + + + ++P G F +F + A+G Sbjct: 295 YFEKYHLEGALLGYKEKRDIMLKALENHLPNAEFTKPIAGMFVMF-----FLPEGADGIS 349 Query: 413 LINDSSSLALYFLDKFQVAMVPGDAFGDD----SCIRISYA 449 N+ +++ V +VPG F D + IR++++ Sbjct: 350 FANE-------LMEREGVVVVPGKPFYTDESGKNAIRLNFS 383 >1IAY-A nrPDB Length = 428 Score = 77.4 bits (189), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 74/347 (21%), Positives = 145/347 (41%), Gaps = 27/347 (7%) Query: 137 GITELREAICRKLKEENG--LSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWV 194 G+ E R+AI + +++ G + + P++++++ GA + + + PGD ++P+PY+ Sbjct: 84 GLPEFRKAIAKFMEKTRGGRVRFDPERVVMAGGATGANETIIFCLADPGDAFLVPSPYYP 143 Query: 195 SYTEQARLADATPVV-IPTKISNNFLLDPKDLE------SKLTEKSRLLILCSPSNPTGS 247 ++ R ++ I + SNNF + K ++ K K + LIL +PSNP G+ Sbjct: 144 AFNRDLRWRTGVQLIPIHCESSNNFKITSKAVKEAYENAQKSNIKVKGLILTNPSNPLGT 203 Query: 248 VYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLT------- 300 K L+ + +H + ++ DEIY ++ S A + D E T Sbjct: 204 TLDKDTLKSVLSFTNQH-NIHLVCDEIYAATVFDTPQFVSIAEILDEQEMTYCNKDLVHI 262 Query: 301 VNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGET 360 V SK + G+R+G + V C++ S+ Q A L K Sbjct: 263 VYSLSKDMGLPGFRVGIIYSFNDDVVNCARKMSSFGL-VSTQTQYFLAAMLSDEKFVDNF 321 Query: 361 VAEMVKAYRERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSL 420 + E +R L ++ G+K + + ++D + SL Sbjct: 322 LRESAMRLGKRHKHFTNGL-EVVGIKCLKNNAGLFCWMDLRPLLREST-----FDSEMSL 375 Query: 421 ALYFLDKFQVAMVPGDAF--GDDSCIRISYATSLD-VLQAAVEKIRK 464 ++ ++ + PG +F + R+ +A D + A+ +IR+ Sbjct: 376 WRVIINDVKLNVSPGSSFECQEPGWFRVCFANMDDGTVDIALARIRR 422 >3QGU-A nrPDB Length = 449 Score = 75.5 bits (184), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 83/360 (23%), Positives = 145/360 (40%), Gaps = 44/360 (12%) Query: 126 REGFTRYTLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDE 185 REG++ Y G LREA+ G A D+I +S+G+K + + + S Sbjct: 101 REGYSGYGAEQGQGALREAVASTFYGHAGR--AADEIFISDGSKCDIARIQMMFGSK-PT 157 Query: 186 VIIPAPYWVSYTEQARLADATPVVIPTKIS----------NNFLLDPKDLESKLTEKSRL 235 V + P + Y + + + T T N+F D +++ + Sbjct: 158 VAVQDPSYPVYVDTSVMMGMTGDHNGTGFDGIEYMVCNPDNHFFPDLSK-----AKRTDI 212 Query: 236 LILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMY 295 + CSP+NPTG+ ++ L E+ K+ +LV D Y I P + +P Sbjct: 213 IFFCSPNNPTGAAATRAQLTELVNFARKNGSILVY-DAAYALYISNPDCPKTIYEIPGAD 271 Query: 296 ERTLTVNGFSKAFAMTGWRLGYLAGPKH--------IVAACSKLQGQVSSGASSIAQKAG 347 E + FSK TG RLG+ PK + A +++ +GAS+I Q G Sbjct: 272 EVAIETCSFSKYAGFTGVRLGWTVVPKALKYANGEPVHADWNRVMTTCFNGASNIVQAGG 331 Query: 348 VAALGLGKAGGETVAEMVKAYRERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSE 407 +A L G + + M+K Y+E L + ++ G + A Y+++ F Sbjct: 332 LAC--LQPEGLKEMNAMIKFYKENAQILKTTFTEM-GFSVYGGDDAPYIWVGFPG----- 383 Query: 408 AEGFGLINDSSSLALYFLDKFQVAMVPGDAFG--DDSCIRISYATSLDVLQAAVEKIRKA 465 S + L++ + PG +G + +R S S + + AV + ++A Sbjct: 384 -------KPSWDVFAEILERCNIVTTPGSGYGPAGEGFVRASAFGSRENILEAVRRFKEA 436 >3OP7-A nrPDB Length = 375 Score = 75.1 bits (183), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 71/308 (23%), Positives = 131/308 (42%), Gaps = 20/308 (6%) Query: 159 PDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNNF 218 P+QIL +NGA + L + ++ PGD VI P + + + A + + N + Sbjct: 81 PEQILQTNGATGANLLVLYSLIEPGDHVISLYPTYQQLYDIPKSLGAEVDLWQIEEENGW 140 Query: 219 LLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHI 278 L D + L + ++++ + + +NPTG+V ++ LEE+ IA +LSDE+Y Sbjct: 141 LPDLEKLRQLIRPTTKMICINNANNPTGAVMDRTYLEELVE-IASEVGAYILSDEVYRSF 199 Query: 279 IYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSG 338 + S+ ++Y++ + VN SK +++ G R+G++A + + Sbjct: 200 -----SELDVPSIIEVYDKGIAVNSLSKTYSLPGIRIGWVAANHQVTDILRDYRDYTMIC 254 Query: 339 ASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLGDIKGVKISEPQGAFYLFI 398 A VA L L A + R L ++L + EP ++ Sbjct: 255 AGVFDDL--VAQLAL--------AHYQEILERNRHILEENLAILDQWIEEEPLVSYIRPA 304 Query: 399 DFSAYYGSEAEGFGLINDSSSLALYFLDKFQVAMVPGDAFGDDSCIRISYATSLDVLQAA 458 S + A + L L + V +VPG+ F D +R+ +A + L Sbjct: 305 VVSTSFVKIAVDMPM----EDFCLQLLQEHGVLLVPGNRFERDGYVRLGFACEQETLIKG 360 Query: 459 VEKIRKAL 466 +EK+ + L Sbjct: 361 LEKLSQFL 368 >1IJI-A nrPDB Length = 356 Score = 72.0 bits (175), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 91/329 (27%), Positives = 143/329 (43%), Gaps = 35/329 (10%) Query: 84 TMVITDLAATLVQSGVPV--IRLAAGEPDFDTPKVVAEAGINAIREGFTRYTLNAGITEL 141 T+ ITDLA V++ P R G D + A A+ T+ TLN Sbjct: 3 TVTITDLARENVRNLTPYQSARRLGGNGDV---WLNANEYPTAVEFQLTQQTLN------ 53 Query: 142 REAICR-KLKEENGLSYA---PDQILVSNGAKQSLLQAVLAVCSPG-DEVIIPAPYWVSY 196 R C+ K EN YA P+Q+LVS GA + + + A C PG D ++ P + Y Sbjct: 54 RYPECQPKAVIENYAQYAGVKPEQVLVSRGADEGIELLIRAFCEPGKDAILYCPPTYGMY 113 Query: 197 TEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGS-VYPKSL-- 253 + A +PT +N+ LD + + KL + +++ +CSP+NPTG + P+ Sbjct: 114 SVSAETIGVECRTVPTL--DNWQLDLQGISDKL-DGVKVVYVCSPNNPTGQLINPQDFRT 170 Query: 254 LEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGW 313 L E+ R + +V++DE Y I + P S A Y + SKAFA+ G Sbjct: 171 LLELTR-----GKAIVVADEAY--IEFCP--QASLAGWLAEYPHLAILRTLSKAFALAGL 221 Query: 314 RLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRD 373 R G+ + ++ L +V + A +AA L G + E V R+ Sbjct: 222 RCGFTLANEEVI----NLLMKVIAPYPLSTPVADIAAQALSPQGIVAMRERVAQIIAERE 277 Query: 374 FLVKSLGDIKGVKISEPQGAFYLFIDFSA 402 +L+ +L +I V+ Y+ F A Sbjct: 278 YLIAALKEIPCVEQVFDSETNYILARFKA 306 >3AV7-A nrPDB Length = 448 Score = 71.6 bits (174), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 88/356 (24%), Positives = 163/356 (45%), Gaps = 42/356 (11%) Query: 101 VIRLAAGEPDFDT-PKVVAEAGINAIREGFT----RYTLNAGITELREAICRKLKEENGL 155 +I LA G P+ T PK + + I E + +Y G T LRE + + L + G+ Sbjct: 78 IISLAGGLPNPKTFPKEIIRDILVEIMEKYADKALQYGTTKGFTPLRETLMKWLGKRYGI 137 Query: 156 SYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKIS 215 S D I++++G++Q+L +PGD V++ AP +++ + + + IP Sbjct: 138 SQDND-IMITSGSQQALDLIGRVFLNPGDIVVVEAPTYLAALQAFNFYEPQYIQIPL--- 193 Query: 216 NNFLLDPKDLESKLTE-----KSRLLILCSPS--NPTGSVYP----KSLLEEIARIIAKH 264 ++ + + LE KL E K ++ P+ NP G K LLE +A Sbjct: 194 DDEGMKVEILEEKLKELKSQGKKVKVVYTVPTFQNPAGVTMNEDRRKYLLE-----LASE 248 Query: 265 PRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHI 324 +V+ D+ Y + Y+ +L D R + + FSK A G+R+G++ G I Sbjct: 249 YDFIVVEDDPYGELRYSGNPEKKIKAL-DNEGRVIYLGTFSKILA-PGFRIGWMVGDPGI 306 Query: 325 VAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLGDI-- 382 + ++ Q + +++ + G + + E+ K Y+ RRD ++++L + Sbjct: 307 IRKM-EIAKQSTDLCTNVFGQVVAWRYVDGGYLEKHIPEIRKFYKPRRDAMLEALEEFMP 365 Query: 383 KGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVAMVPGDAF 438 +GVK ++P+G ++++ +G DS + + K VA VPG+AF Sbjct: 366 EGVKWTKPEGGMFIWVTL-------PDGI----DSKKMLERAIKK-GVAYVPGEAF 409 >1X0M-A nrPDB Length = 403 Score = 71.6 bits (174), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 88/356 (24%), Positives = 163/356 (45%), Gaps = 42/356 (11%) Query: 101 VIRLAAGEPDFDT-PKVVAEAGINAIREGFT----RYTLNAGITELREAICRKLKEENGL 155 +I LA G P+ T PK + + I E + +Y G T LRE + + L + G+ Sbjct: 33 IISLAGGLPNPKTFPKEIIRDILVEIMEKYADKALQYGTTKGFTPLRETLMKWLGKRYGI 92 Query: 156 SYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKIS 215 S D I++++G++Q+L +PGD V++ AP +++ + + + IP Sbjct: 93 SQDND-IMITSGSQQALDLIGRVFLNPGDIVVVEAPTYLAALQAFNFYEPQYIQIPL--- 148 Query: 216 NNFLLDPKDLESKLTE-----KSRLLILCSPS--NPTGSVYP----KSLLEEIARIIAKH 264 ++ + + LE KL E K ++ P+ NP G K LLE +A Sbjct: 149 DDEGMKVEILEEKLKELKSQGKKVKVVYTVPTFQNPAGVTMNEDRRKYLLE-----LASE 203 Query: 265 PRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHI 324 +V+ D+ Y + Y+ +L D R + + FSK A G+R+G++ G I Sbjct: 204 YDFIVVEDDPYGELRYSGNPEKKIKAL-DNEGRVIYLGTFSKILA-PGFRIGWMVGDPGI 261 Query: 325 VAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLGDI-- 382 + ++ Q + +++ + G + + E+ K Y+ RRD ++++L + Sbjct: 262 IRKM-EIAKQSTDLCTNVFGQVVAWRYVDGGYLEKHIPEIRKFYKPRRDAMLEALEEFMP 320 Query: 383 KGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVAMVPGDAF 438 +GVK ++P+G ++++ +G DS + + K VA VPG+AF Sbjct: 321 EGVKWTKPEGGMFIWVTLP-------DGI----DSKKMLERAIKK-GVAYVPGEAF 364 >3F6T-A nrPDB Length = 533 Score = 70.1 bits (170), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 43/144 (29%), Positives = 78/144 (54%), Gaps = 9/144 (6%) Query: 179 VCSPGDEVIIPAPYWVSYTEQARLAD--ATPVVIPTKISNNFLLDPKDLESKLTEKS-RL 235 + GD++ I P + Y L D V + + N++ ++P ++E KL + S + Sbjct: 189 LLKKGDKIAINEPIFTPYLRIPELKDYELVEVDLHSYEKNDWEIEPNEIE-KLKDPSIKA 247 Query: 236 LILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMY 295 LI+ +P+NPT + + L I + + K+P+L+++SDE+Y + P + ++ +P Sbjct: 248 LIVVNPTNPTSKEFDTNALNAIKQAVEKNPKLMIISDEVYG--AFVPNFKSIYSVVP--- 302 Query: 296 ERTLTVNGFSKAFAMTGWRLGYLA 319 T+ V +SK F TGWRLG +A Sbjct: 303 YNTMLVYSYSKLFGCTGWRLGVIA 326 >2ZY3-A nrPDB Length = 546 Score = 67.8 bits (164), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 55/156 (35%), Positives = 77/156 (49%), Gaps = 12/156 (7%) Query: 183 GDEVIIPAPYWVSYTEQARLADAT--PVVIPTKISNNFLLDPKDLESKLTEKSRLLILC- 239 GD+V I P + Y E LA V I S N+ +L+ KL + + + C Sbjct: 194 GDKVAIGMPVFTPYIEIPELAQYALEEVAINADPSLNWQYPDSELD-KLKDPAIKIFFCV 252 Query: 240 SPSNPTGSVYPKSLLEEIARIIAKH-PRLLVLSDEIYEHIIYAPATHTSFASLPDMYERT 298 +PSNP + LE + I+A+H P L++L+D++Y +A + FA P E T Sbjct: 253 NPSNPPSVKMDQRSLERVRNIVAEHRPDLMILTDDVYG--TFADDFQSLFAICP---ENT 307 Query: 299 LTVNGFSKAFAMTGWRLGYLAGPKHIV--AACSKLQ 332 L V FSK F TGWRLG +A + V A KLQ Sbjct: 308 LLVYSFSKYFGATGWRLGVVAAHQQNVFDLALDKLQ 343 >4GDY-A nrPDB Length = 439 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 106/432 (24%), Positives = 190/432 (43%), Gaps = 66/432 (15%) Query: 80 KPSKTMVITDLAATLVQSGVPVIRLAAGEPD-----FDTPKVVAEAG--INAIREGFTR- 131 PS +TD+ + +S +I LA G P+ F T + E G I E R Sbjct: 15 NPSPIRTMTDILSRGPKS---MISLAGGLPNPNMFPFKTAVITVENGKTIQFGEEMMKRA 71 Query: 132 --YTLNAGITELREAICR---KLKEENGLSYAPDQ----ILVSNGAKQSLLQAVLAVCSP 182 Y+ +AGI EL + + KL + Y P Q + V++G++Q L + + +P Sbjct: 72 LQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINP 131 Query: 183 GDEVIIPAPYWVSYTEQA---------RLADATPVVIPTKISNNF-LLDPKDLESKLTEK 232 GD V++ P + S T Q+ +A ++P + + P+D ++ Sbjct: 132 GDNVLLDEPAY-SGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNT 190 Query: 233 SRLL-ILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASL 291 + L + + +NPTG+ +EI + K+ L++ D+ Y + + +F S+ Sbjct: 191 PKFLYTVPNGNNPTGNSLTSERKKEIYELARKY-DFLIIEDDPYYFLQFNSGRVPTFLSM 249 Query: 292 PDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAAL 351 D+ R + + FSK + +G R+G+L GPK ++ L QVS+ S + ++ L Sbjct: 250 -DVDGRVIRADSFSKIIS-SGLRIGFLTGPKPLIERVI-LHIQVSTLHPSTFNQLMISQL 306 Query: 352 GLGKAGGE----TVAEMVKAYRERRDFLVKSLGDIKGVKISE---PQGAFYLFIDFSAYY 404 L + G E V ++ Y ++D ++ + D ++E P +L+I Sbjct: 307 -LHEWGEEGFMAHVDRVIDFYSNQKDAILAA-ADKWLTGLAEWHVPAAGMFLWIKVKG-- 362 Query: 405 GSEAEGFGLINDSSSLALYFLDKFQVAMVPGDAFGDDSC-----IRISYATS----LDV- 454 IND L K V M+PG+AF DS +R S++++ +DV Sbjct: 363 ---------INDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVA 413 Query: 455 LQAAVEKIRKAL 466 Q + I+++L Sbjct: 414 FQVLAQLIKESL 425 >3FDD-A nrPDB Length = 533 Score = 64.7 bits (156), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 50/154 (32%), Positives = 75/154 (48%), Gaps = 10/154 (6%) Query: 176 VLAVCSPGDEVIIPAPYWVSYTEQARLADAT--PVVIPTKISNNFLLDPKDLESKLTEKS 233 V + GD+V I P + Y E LA V I + N+ +L+ KL + + Sbjct: 187 VNGLLKAGDKVAIGMPVFTPYIEIPELAQYALEEVAINADPALNWQYPDSELD-KLKDPA 245 Query: 234 RLLILC-SPSNPTGSVYPKSLLEEIARIIAKH-PRLLVLSDEIYEHIIYAPATHTSFASL 291 + C +PSNP + LE + +I+A+H P L++L+D++Y +A + FA Sbjct: 246 IKIFFCVNPSNPPSVKMDERSLERVRKIVAEHRPDLMILTDDVYG--TFADGFQSLFAIC 303 Query: 292 PDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIV 325 P TL V FSK F TGWRLG +A K + Sbjct: 304 P---ANTLLVYSFSKYFGATGWRLGVVAAHKENI 334 >3EUC-A nrPDB Length = 367 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 56/192 (29%), Positives = 92/192 (47%), Gaps = 11/192 (5%) Query: 143 EAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARL 202 EA+ KLKE + A ++L+ NG+ + + LA PG +V+ P P +V Y A+ Sbjct: 70 EALRAKLKEVMQVP-AGMEVLLGNGSDEIISMLALAAARPGAKVMAPVPGFVMYAMSAQF 128 Query: 203 ADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLI-LCSPSNPTGSVYPKSLLEEIARII 261 A V +P + +F LD + + + E ++ L P+NPTG+++ + +E I R Sbjct: 129 AGLEFVGVPLRA--DFTLDRGAMLAAMAEHQPAIVYLAYPNNPTGNLFDAADMEAIVRAA 186 Query: 262 AKHP-RLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYLAG 320 R LV+ DE Y+ P S+ S + L + SK + G RLGY+AG Sbjct: 187 QGSVCRSLVVVDEAYQ-----PFAQESWMSRLTDFGNLLVMRTVSK-LGLAGIRLGYVAG 240 Query: 321 PKHIVAACSKLQ 332 + K++ Sbjct: 241 DPQWLEQLDKVR 252 >3EZS-A nrPDB Length = 376 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 58/252 (23%), Positives = 107/252 (42%), Gaps = 9/252 (3%) Query: 104 LAAGEPDFDTPKVVAEAGINAIREGFTRYTLNAGITELREAICRKLKEENGLSYAPDQIL 163 L GEP F+TPK + +A N Y +A LR A K + ++++ Sbjct: 28 LGIGEPQFETPKFIQDALKNHTH-SLNIYPKSAFEESLRAAQRGFFKRRFKIELKENELI 86 Query: 164 VSNGAKQSLLQ--AVLAVCSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNNFLLD 221 + G+++ L + + + P P++ Y A+ A +++P N+F Sbjct: 87 STLGSREVLFNFPSFVLFDYQNPTIAYPNPFYQIYEGAAKFIKAKSLLMPLTKENDFT-- 144 Query: 222 PKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSD---EIYEHI 278 L K ++ L+IL SP+NPTG L ++ KH +L+ + EIYE+ Sbjct: 145 -PSLNEKELQEVDLVILNSPNNPTGRTLSLEELISWVKLALKHDFILINDECYSEIYENT 203 Query: 279 IYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSG 338 + + ++ L ++ SK + G R G++AG ++ + + Sbjct: 204 PPPSLLEACMLAGNEAFKNVLVIHSLSKRSSAPGLRSGFIAGDSRLLEKYKAFRAYLGYT 263 Query: 339 ASSIAQKAGVAA 350 +++ QKA AA Sbjct: 264 SANAIQKASEAA 275 >3CQ5-A nrPDB Length = 369 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 73/290 (25%), Positives = 129/290 (44%), Gaps = 22/290 (7%) Query: 120 AGINAIREGFTRYTLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAV 179 A ++ I RY + ELR+ + + ++ G++ D + +NG+ + L Q + A Sbjct: 54 ATVDKIATELNRYPERDAV-ELRDELAAYITKQTGVAVTRDNLWAANGSNEILQQLLQAF 112 Query: 180 CSPGDEVIIPAPYWVSYTEQARLADATPV-VIPTKISNNFLLDPK-DLESKLTEKSRLLI 237 PG + P SY+ LA T I +F +D LE ++ ++ Sbjct: 113 GGPGRTALGFQP---SYSMHPILAKGTHTEFIAVSRGADFRIDMDVALEEIRAKQPDIVF 169 Query: 238 LCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYER 297 + +P+NPTG V + L+++ RII P ++++ DE Y +P+ T P + Sbjct: 170 VTTPNNPTGDV---TSLDDVERIINVAPGIVIV-DEAYAEFSPSPSATTLLEKYP---TK 222 Query: 298 TLTVNGFSKAFAMTGWRLGY-LAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKA 356 + SKAF G RLGY +A P I A + ++ S+++Q A + AL + Sbjct: 223 LVVSRTMSKAFDFAGGRLGYFVANPAFIDAV---MLVRLPYHLSALSQAAAIVAL---RH 276 Query: 357 GGETVAEMVKAYRERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGS 406 +T+ + K ER V + + G + + F F DFS + + Sbjct: 277 SADTLGTVEKLSVER--VRVAARLEELGYAVVPSESNFVFFGDFSDQHAA 324 >3IHJ-A nrPDB Length = 498 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 79/371 (21%), Positives = 154/371 (41%), Gaps = 40/371 (10%) Query: 132 YTLNAGITELREAICRKL-KEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDE----V 186 Y+ + G+ +RE + + + + G+ PD I ++ GA + + + S G + V Sbjct: 125 YSASQGVNCIREDVAAYITRRDGGVPADPDNIYLTTGASDGISTILKILVSGGGKSRTGV 184 Query: 187 IIPAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKS-----RLLILCSP 241 +IP P + Y+ DA V N + L+ +L + E ++L + +P Sbjct: 185 MIPIPQYPLYSAVISELDAIQVNYYLDEENCWALNVNELRRAVQEAKDHCDPKVLCIINP 244 Query: 242 SNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPAT--HTSFASLPDM---YE 296 NPTG V + +E++ A +L +L+DE+Y+ +Y+P H+ L +M Y Sbjct: 245 GNPTGQVQSRKCIEDVIH-FAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPEYS 303 Query: 297 RTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGAS-----SIAQKAGVAAL 351 + + F GY G ++ +++GQ+ S ++ +A + + Sbjct: 304 SNVELASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQLVKLLSVRLCPPVSGQAAMDIV 363 Query: 352 GLGKAGGETVAEMVKAYRE-------RRDFLVKSL-GDIKGVKISEPQGAFY----LFID 399 GE E +E ++ L + L + G+ + QGA Y +FI Sbjct: 364 VNPPVAGEESFEQFSREKESVLGNLAKKAKLTEDLFNQVPGIHCNPLQGAMYAFPRIFIP 423 Query: 400 FSAYYGSEAEGFGLINDSSSLALYFLDKFQVAMVPGDAFGDDSCIRISYATSLDVLQAAV 459 A ++A + L++ + +VPG FG +Y + +L V Sbjct: 424 AKAVEAAQAHQMA---PDMFYCMKLLEETGICVVPGSGFGQREG---TYHFRMTIL-PPV 476 Query: 460 EKIRKALEPLR 470 EK++ L+ ++ Sbjct: 477 EKLKTVLQKVK 487 >4RAE-A nrPDB Length = 394 Score = 62.8 bits (151), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 85/312 (27%), Positives = 136/312 (43%), Gaps = 26/312 (8%) Query: 96 QSGVPVIRLAAGEPDFDTPKVVAEAGINAIREG---FTRYTLNAGITELREAICRKLKEE 152 Q VPV RL E + + + + ++RE RY + LR + L + Sbjct: 30 QLAVPV-RLNTNENPHPPTRALVDDVVRSVREAAIDLHRYPDRDAVA-LRADLAGYLTAQ 87 Query: 153 NGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADATPV-VIP 211 G+ + I +NG+ + L Q + A PG I P SY+ ++D T I Sbjct: 88 TGIQLGVENIWAANGSNEILQQLLQAFGGPGRSAIGFVP---SYSMHPIISDGTHTEWIE 144 Query: 212 TKISNNF-LLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVL 270 +N+F L + + + K ++ + SP+NP+G L ++ +++ P + ++ Sbjct: 145 ASRANDFGLDVDVAVAAVVDRKPDVVFIASPNNPSGQ---SVSLPDLCKLLDVAPGIAIV 201 Query: 271 SDEIYEHIIYAPATHTSFASLPDMYERTLTVN-GFSKAFAMTGWRLGYLAGPKHIVAACS 329 DE Y P S SL + Y L V SKAFA G RLGYL ++ A Sbjct: 202 -DEAYGEFSSQP----SAVSLVEEYPSKLVVTRTMSKAFAFAGGRLGYLIATPAVIDAM- 255 Query: 330 KLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLGDIKGVKISE 389 L ++ SS+ Q A AAL +VA ++ A RER + SL D+ G ++ Sbjct: 256 -LLVRLPYHLSSVTQAAARAALRHSDDTLSSVAALI-AERER---VTTSLNDM-GFRVIP 309 Query: 390 PQGAFYLFIDFS 401 F LF +F+ Sbjct: 310 SDANFVLFGEFA 321 >3TCM-A nrPDB Length = 500 Score = 62.0 bits (149), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 83/351 (23%), Positives = 141/351 (40%), Gaps = 62/351 (17%) Query: 132 YTLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSL-LQAVLAVCSPGDEVIIPA 190 Y+ + GI LR+AI + +G D I +++GA + L L + + D +++P Sbjct: 130 YSHSQGIHGLRDAIASGIASRDGFPANADDIFLTDGASPGVHLMMQLLIRNEKDGILVPI 189 Query: 191 PYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTE------KSRLLILCSPSNP 244 P + Y+ L V S + L+ D++ +L + R L++ +P NP Sbjct: 190 PQYPLYSASIALHGGALVPYYLNESTGWGLETSDVKKQLEDARSRGINVRALVVINPGNP 249 Query: 245 TGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMY------ERT 298 TG V + +I + K+ L++L+DE+Y+ IY + F S + E Sbjct: 250 TGQVLAEENQYDIVK-FCKNEGLVLLADEVYQENIY--VDNKKFHSFKKIVRSLGYGEED 306 Query: 299 LTVNGFSKA----FAMTGWRLGY-----LAGP--KHI-----VAACSKLQGQV------- 335 L + + + G R GY + P + I V CS + GQ+ Sbjct: 307 LPLVSYQSVSKGYYGECGKRGGYFEITGFSAPVREQIYKIASVNLCSNITGQILASLVMN 366 Query: 336 ------SSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLGDIKGVKISE 389 S AS A+K G+ A ++A KA L + ++G+ +E Sbjct: 367 PPKASDESYASYKAEKDGILA---------SLARRAKA-------LEHAFNKLEGITCNE 410 Query: 390 PQGAFYLFIDFS-AYYGSEAEGFGLINDSSSLALYFLDKFQVAMVPGDAFG 439 +GA Y+F EA + AL L+ + +VPG FG Sbjct: 411 AEGAMYVFPQICLPQKAIEAAKAANKAPDAFYALRLLESTGIVVVPGSGFG 461 >2ZY2-A nrPDB Length = 544 Score = 62.0 bits (149), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 46/146 (31%), Positives = 67/146 (45%), Gaps = 8/146 (5%) Query: 183 GDEVIIPAPYWVSYTEQARLA--DATPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCS 240 GD+V I P + Y E LA D V I N + +L+ ++ + Sbjct: 193 GDKVAIGMPVFTPYIEIPELAQYDLKEVPIHADPDNGWQYSDAELDKLKDPDVKIFFCVN 252 Query: 241 PSNPTGSVYPKSLLEEIARIIAKH-PRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTL 299 PSNP + L+ + I+A+ P LL+L+D++Y +A + F+ P TL Sbjct: 253 PSNPPSVKMDQRSLDRVRAIVAEQRPDLLILTDDVYG--TFADEFQSLFSVCP---RNTL 307 Query: 300 TVNGFSKAFAMTGWRLGYLAGPKHIV 325 V FSK F TGWRLG +A K V Sbjct: 308 LVYSFSKYFGATGWRLGVIAAHKDNV 333 >1M4N-A nrPDB Length = 435 Score = 62.0 bits (149), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 58/266 (21%), Positives = 116/266 (43%), Gaps = 25/266 (9%) Query: 153 NGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADATPVV-IP 211 N +++ P+ ++++ GA + + + PG+ V+IP PY+ + + +V I Sbjct: 105 NKVTFDPNHLVLTAGATSANETFIFCLADPGEAVLIPTPYYPGFDRDLKWRTGVEIVPIH 164 Query: 212 TKISNNFLLDPKDLESKLTE------KSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHP 265 SN F + LE E + + +++ +PSNP G+ ++ L + + + Sbjct: 165 CTSSNGFQITETALEEAYQEAEKRNLRVKGVLVTNPSNPLGTTMTRNELYLLLSFV-EDK 223 Query: 266 RLLVLSDEIYEHIIYAPATHTSFASL---------PDMYERTLTVNGFSKAFAMTGWRLG 316 + ++SDEIY ++ + S + ++++R V SK + G+R+G Sbjct: 224 GIHLISDEIYSGTAFSSPSFISVMEVLKDRNCDENSEVWQRVHVVYSLSKDLGLPGFRVG 283 Query: 317 YL-AGPKHIVAACSKLQ--GQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRD 373 + + +VAA +K+ G VSS + A L K +AE K ++R+ Sbjct: 284 AIYSNDDMVVAAATKMSSFGLVSSQTQHLLS----AMLSDKKLTKNYIAENHKRLKQRQK 339 Query: 374 FLVKSLGDIKGVKISEPQGAFYLFID 399 LV L G+ + ++D Sbjct: 340 KLVSGLQK-SGISCLNGNAGLFCWVD 364 >3HDO-A nrPDB Length = 360 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 67/259 (25%), Positives = 116/259 (44%), Gaps = 31/259 (11%) Query: 144 AICRKLKEENGLSYA--PDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQAR 201 A +KL+E G Y P I+++NG+ + L + A + G+E+ P SY+ Sbjct: 65 ASSQKLREVAGELYGFDPSWIIMANGSDEVLNNLIRAFAAEGEEIGYVHP---SYSYYGT 121 Query: 202 LADATPVVIPT-KISNNFLLD--PKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIA 258 LA+ + T ++ +F + P+ E K+ L +P+ P G +P ++E+A Sbjct: 122 LAEVQGARVRTFGLTGDFRIAGFPERYEGKV------FFLTTPNAPLGPSFPLEYIDELA 175 Query: 259 RIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYL 318 R A +LVL + YA ++ L +E + SK++++ G R+G Sbjct: 176 RRCAG---MLVLDE------TYAEFAESNALELVRRHENVVVTRTLSKSYSLAGMRIGLA 226 Query: 319 AGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKS 378 ++AA K++ + +AQ A VAAL ++E + RE R++ Sbjct: 227 IARPEVIAALDKIRDHYN--LDRLAQAACVAAL----RDQAYLSECCRRIRETREWFTTE 280 Query: 379 LGDIKGVKISEPQGAFYLF 397 L I G + QG YLF Sbjct: 281 LRSI-GYDVIPSQGN-YLF 297 >3EI8-A nrPDB Length = 432 Score = 59.7 bits (143), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 73/329 (22%), Positives = 132/329 (40%), Gaps = 46/329 (13%) Query: 101 VIRLAAGEPDFDTPKVVAEAGINAIRE-----GFTRYTLNAGITELREAICRKLKEENGL 155 VI L G+ P+V+ A E G++ Y G LR AI + GL Sbjct: 58 VISLGIGDTTEPIPEVITSAMAKKAHELSTIEGYSGYGAEQGAKPLRAAIAKTFY--GGL 115 Query: 156 SYAPDQILVSNGAKQSL--LQAVLAVCSPGDEVIIPA--PYWVSYTEQARLADATPVV-- 209 D + VS+GAK + LQ + G V I P + +Y + + + T Sbjct: 116 GIGDDDVFVSDGAKCDISRLQVMF-----GSNVTIAVQDPSYPAYVDSSVIMGQTGQFNT 170 Query: 210 ----------IPTKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIAR 259 + N F D + ++ ++ CSP+NPTG+ + L ++ Sbjct: 171 DVQKYGNIEYMRCTPENGFFPDLSTVG-----RTDIIFFCSPNNPTGAAATREQLTQLVE 225 Query: 260 IIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYLA 319 K+ ++V D Y + + F +P E + FS TG RLG+ Sbjct: 226 FAKKNGSIIVY-DSAYAMYMSDDNPRSIF-EIPGAEEVAMETASFSNYAGFTGVRLGWTV 283 Query: 320 GPKHIVAA--------CSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRER 371 PK ++ + +++ +GAS+I+Q +A L G E + +++ Y+E Sbjct: 284 IPKKLLYSDGFPVAKDFNRIICTCFNGASNISQAGALAC--LTPEGLEAMHKVIGFYKEN 341 Query: 372 RDFLVKSLGDIKGVKISEPQGAFYLFIDF 400 + ++ + + G + + A Y+++ F Sbjct: 342 TNIIIDTFTSL-GYDVYGGKNAPYVWVHF 369 >2ZYJ-A nrPDB Length = 397 Score = 58.2 bits (139), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 79/327 (24%), Positives = 147/327 (44%), Gaps = 32/327 (9%) Query: 159 PDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNNF 218 P+++L++ G++Q+L G V++ AP ++ + RL + +P Sbjct: 91 PEEVLITTGSQQALDLVGKVFLDEGSPVLLEAPSYMGAIQAFRLQGPRFLTVPAGEEGP- 149 Query: 219 LLDPKDLESKLT-EKSRLLILC-SPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYE 276 D LE L E+ R L L S NPTG + P + + +++ + L+V+ D+ Y Sbjct: 150 --DLDALEEVLKRERPRFLYLIPSFQNPTGGLTPLPARKRLLQMVMER-GLVVVEDDAYR 206 Query: 277 HIIYAPATHTSFASLPDM--YERTLTVNGFSKAFAMTGWRLGY-LAGPKHIVAACSKLQG 333 + + A S L Y + + FSK + G R+ + +A P+ + QG Sbjct: 207 ELYFGEARLPSLFELAREAGYPGVIYLGSFSKVLS-PGLRVAFAVAHPEALQKLVQAKQG 265 Query: 334 QVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLGD--IKGVKISEPQ 391 + + + + V L L + E + + + YRE+ ++ +L K V+ + P+ Sbjct: 266 --ADLHTPMLNQMLVHEL-LKEGFSERLERVRRVYREKAQAMLHALDREVPKEVRYTRPK 322 Query: 392 GAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVAMVPGDAF----GDDSCIRIS 447 G +++++ G AEG L L++ VA VPG F G ++ +R+S Sbjct: 323 GGMFVWMELPK--GLSAEG---------LFRRALEE-NVAFVPGGPFFANGGGENTLRLS 370 Query: 448 YAT-SLDVLQAAVEKIRKALEPLRATV 473 YAT + + V ++ +AL+ L A V Sbjct: 371 YATLDREGIAEGVRRLGRALKGLLALV 397 >3GET-A nrPDB Length = 365 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 65/268 (24%), Positives = 117/268 (43%), Gaps = 21/268 (7%) Query: 89 DLAATLVQSGVP-VIRLAAGEPDFDTPKVVAEAGINAIREGFTRYTL--NAGITELREAI 145 D+ + GV VI+LA+ E F TP I +R+ + L + + EL+ + Sbjct: 19 DIEVIAKEYGVKEVIKLASNENPFGTPP----KAIECLRQNANKAHLYPDDSMIELKSTL 74 Query: 146 CRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADA 205 +K K +N + I++ G+ Q + A+ + + + + + Y A+ A Sbjct: 75 AQKYKVQN------ENIIIGAGSDQVIEFAIHSKLNSKNAFLQAGVTFAMYEIYAKQCGA 128 Query: 206 TPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHP 265 + I++N L + K L ++ +L+ LC P+NP G S E + + + Sbjct: 129 KCYKTQS-ITHN-LDEFKKLYETHKDEIKLIFLCLPNNPLGECLDASEATEFIKGV--NE 184 Query: 266 RLLVLSDEIYEHI--IYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKH 323 LV+ D Y H L ++ L + FSK + + G R+GY + Sbjct: 185 DCLVVIDAAYNEFASFKDSKKHLEPCELIKEFDNVLYLGTFSKLYGLGGLRIGYGIANAN 244 Query: 324 IVAACSKLQGQVSSGASSIAQKAGVAAL 351 I++A KL+ + S++A KA VAA+ Sbjct: 245 IISAFYKLRAPFN--VSNLALKAAVAAM 270 >3DZZ-A nrPDB Length = 391 Score = 55.1 bits (131), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 64/263 (24%), Positives = 120/263 (45%), Gaps = 21/263 (7%) Query: 160 DQILVSNGAKQSLLQAVLAVCSPGDEVIIPAP-----YWVSYTEQARLADATPVVIPTKI 214 D + ++G ++ V SPGD++++ P Y V R+ + + +K Sbjct: 86 DWCVFASGVVPAISAMVRQFTSPGDQILVQEPVYNMFYSVIEGNGRRVISSDLIYENSKY 145 Query: 215 SNNFLLDPKDLESKL-TEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDE 273 S N+ DLE KL T R+++ C+P NP G + + ++ IA + AKH ++L++SDE Sbjct: 146 SVNW----ADLEEKLATPSVRMMVFCNPHNPIGYAWSEEEVKRIAELCAKH-QVLLISDE 200 Query: 274 IYEHIIYAPATHT-SFASLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQ 332 I+ ++ T +F D +++ SK F + P + A ++ + Sbjct: 201 IHGDLVLTDEDITPAFTVDWDAKNWVVSLISPSKTFNLAALHAACAIIPNPDLRARAE-E 259 Query: 333 GQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRER----RDFLVKSLGDIKGVKIS 388 +G A AA+ + G + + E+ + R+ R+FL K ++ VK+ Sbjct: 260 SFFLAGIGEPNLLAIPAAIAAYEEGHDWLRELKQVLRDNFAYAREFLAK---EVPEVKVL 316 Query: 389 EPQGAFYLFIDFSAYYGSEAEGF 411 + ++ ++D SA G AE F Sbjct: 317 DSNASYLAWVDISA-LGMNAEDF 338 >4M2J-A nrPDB Length = 406 Score = 54.3 bits (129), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 66/313 (21%), Positives = 125/313 (39%), Gaps = 22/313 (7%) Query: 160 DQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNNFL 219 D++LV++G+ +++ + A+ GD V++ + S R A V+P + + Sbjct: 103 DRVLVTHGSSEAIALTLNALLHRGDRVVVQEGIYHSLGHYPRAAGCDVAVLPGRAVRDGE 162 Query: 220 LDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHII 279 +DP L +T + +I+ P NPTG L + A +LV E Sbjct: 163 IDPDVLAGLVTPGTAAVIVNFPHNPTGVTLSPQGLRALKERTAATGAVLVWDAATAEIAH 222 Query: 280 YAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGA 339 A D T++ SK F + G R+G+ PK ++ A L+ + + Sbjct: 223 RWEVLADPGADGGD----TVSYGTLSKTFGLPGLRVGWAVAPKELLTATFPLRDRTTLFL 278 Query: 340 SSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLGDIKG-VKISEPQG---AFY 395 S + + A+ + E + R L + + V+ + P+G A Sbjct: 279 SPLVELVAERAV---RHADELIGARAAEARHNLAHLTGWMAAHEELVRWTPPEGGVCALP 335 Query: 396 LF--IDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVAMVPGDAFGDDSCIRISYATSLD 453 +F ++ +A E E F L L++ + +VPG AFG R+ + + Sbjct: 336 VFRELERAAAGPQEVERF---------CLELLERHRTLLVPGTAFGAPHGARLGFGGPQE 386 Query: 454 VLQAAVEKIRKAL 466 +A ++ + + L Sbjct: 387 DFRAGLDGLSRFL 399 >3LY1-A nrPDB Length = 354 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 54/225 (24%), Positives = 102/225 (45%), Gaps = 14/225 (6%) Query: 162 ILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLAD-ATPVVIPTKISNNFLL 220 IL++ G+ + + A+ A S +++IP ++Y + A A V K+ +N+ Sbjct: 71 ILLTAGSSEGIRAAIEAYASLEAQLVIPE---LTYGDGEHFAKIAGMKVTKVKMLDNWAF 127 Query: 221 DPKDLESKLTEKS--RLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHI 278 D + L++ + S ++ L +P+NPTG++ P ++E I +K + + DE Y Sbjct: 128 DIEGLKAAVAAYSGPSIVYLVNPNNPTGTITPADVIEP--WIASKPANTMFIVDEAYAEF 185 Query: 279 IYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSG 338 + P + + E + + FSK AM G R+GY ++A L G+ +G Sbjct: 186 VNDPRFRSISPMITQGAENIILLKTFSKIHAMAGMRVGYAVAHPTVIA----LMGRYVAG 241 Query: 339 ASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLGDIK 383 A + + T ++ K+ R L+K+L D+K Sbjct: 242 EKINFSGVDAALASMNDSAFITYSK--KSNDVSRQILLKALEDLK 284 >4N0B-A nrPDB Length = 479 Score = 52.8 bits (125), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 60/255 (23%), Positives = 116/255 (45%), Gaps = 34/255 (13%) Query: 137 GITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQ---------AVLAVCSPGDEVI 187 GI E+R AI R + G+ P+Q+++ G Q L+Q AV A+ PG Sbjct: 150 GIYEVRAAITRLISLTRGVKCRPEQMIIGAGT-QVLMQLLTELLPKEAVYAMEEPG---- 204 Query: 188 IPAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLE-SKLTEKSRLLILCSPSN--P 244 Y +L + T +LD K + +++T + +++ +PS+ P Sbjct: 205 --------YRRMYQLLKNAGKQVKT-----IMLDEKGMSIAEITRQQPDVLVTTPSHQFP 251 Query: 245 TGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGF 304 +G++ P S ++ A+ PR ++ D+ Y + + SL D ++ + + F Sbjct: 252 SGTIMPVSRRIQLLNWAAEEPRRYIIEDDYDSEFTYDVDSIPALQSL-DRFQNVIYMGTF 310 Query: 305 SKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEM 364 SK+ + G R+ Y+ P ++ A K +G SS+ Q + G+ + + +M Sbjct: 311 SKSL-LPGLRISYMVLPPELLRAY-KQRGYDLQTCSSLTQLTLQEFIESGEY-QKHIKKM 367 Query: 365 VKAYRERRDFLVKSL 379 + Y+E+R+ L+ +L Sbjct: 368 KQHYKEKRERLITAL 382 >1D2F-A nrPDB Length = 390 Score = 52.8 bits (125), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 71/302 (23%), Positives = 136/302 (45%), Gaps = 36/302 (11%) Query: 183 GDEVIIPAPYWVSYTE--QARLADATPVVIPTKISNNFLLDPKDLESKLTE-KSRLLILC 239 G+ V+I P + ++ + + PV + K ++ + D LE+ L + + ++++LC Sbjct: 111 GEGVVIHTPAYDAFYKAIEGNQRTVMPVAL-EKQADGWFCDMGKLEAVLAKPECKIMLLC 169 Query: 240 SPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTL 299 SP NPTG V+ LE +A + +H + V+SDEI+ +++ H ++++ + L Sbjct: 170 SPQNPTGKVWTCDELEIMADLCERHG-VRVISDEIHMDMVWGEQPHIPWSNVARG-DWAL 227 Query: 300 TVNGFSKAF---AMTGWRLGYLAGPKHIVAACSKLQGQVS-SGASSIAQKAGVAALGLGK 355 +G SK+F A+TG G + A S L+G+ S S +A A +AA G Sbjct: 228 LTSG-SKSFNIPALTG-AYGIIENSSSRDAYLSALKGRDGLSSPSVLALTAHIAAYQQG- 284 Query: 356 AGGETVAEMVKAYRERRDFLVKSLGDIKGVKISE-----PQGAFYLFIDFSAYYGSEAEG 410 A + A R + + D E PQ + ++D Sbjct: 285 ------APWLDALRIYLKDNLTYIADKMNAAFPELNWQIPQSTYLAWLDLRP-------- 330 Query: 411 FGLINDSSSLALYFLDKFQVAMVPGDAFGDD--SCIRISYATSLDVLQAAVEKIRKALEP 468 L D ++L +++ +VA++PG +G++ +R++ L+ V + A+ Sbjct: 331 --LNIDDNALQKALIEQEKVAIMPGYTYGEEGRGFVRLNAGCPRSKLEKGVAGLINAIRA 388 Query: 469 LR 470 +R Sbjct: 389 VR 390 >5X03-B nrPDB Length = 365 Score = 52.4 bits (124), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 60/255 (23%), Positives = 116/255 (45%), Gaps = 34/255 (13%) Query: 137 GITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQ---------AVLAVCSPGDEVI 187 GI E+R AI R + G+ P+Q+++ G Q L+Q AV A+ PG Sbjct: 43 GIYEVRAAITRLISLTRGVKCRPEQMIIGAGT-QVLMQLLTELLPKEAVYAMEEPG---- 97 Query: 188 IPAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLE-SKLTEKSRLLILCSPSN--P 244 Y +L + T +LD K + +++T + +++ +PS+ P Sbjct: 98 --------YRRMYQLLKNAGKQVKT-----IMLDEKGMSIAEITRQQPDVLVTTPSHQFP 144 Query: 245 TGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGF 304 +G++ P S ++ A+ PR ++ D+ Y + + SL D ++ + + F Sbjct: 145 SGTIMPVSRRIQLLNWAAEEPRRYIIEDDYDSEFTYDVDSIPALQSL-DRFQNVIYMGTF 203 Query: 305 SKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEM 364 SK+ + G R+ Y+ P ++ A K +G SS+ Q + G+ + + +M Sbjct: 204 SKSL-LPGLRISYMVLPPELLRAY-KQRGYDLQTCSSLTQLTLQEFIESGEY-QKHIKKM 260 Query: 365 VKAYRERRDFLVKSL 379 + Y+E+R+ L+ +L Sbjct: 261 KQHYKEKRERLITAL 275 >3FFH-A nrPDB Length = 363 Score = 52.4 bits (124), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 47/171 (27%), Positives = 80/171 (46%), Gaps = 20/171 (11%) Query: 187 IIPAPYWVSYTEQARLADATPVVIPTKISNNFLLD-PKDLESKLT---EKSRLLILCSPS 242 ++ P +V Y + A + A IP L D DLE L EK+ ++ +C+P+ Sbjct: 112 VMATPTFVQYRQNALIEGAEVREIP------LLQDGEHDLEGMLNAIDEKTTIVWICNPN 165 Query: 243 NPTGSVYPKSLLEEIARIIAKHPR-LLVLSDEIY-EHIIYAPATHTSFASLPDMYERTLT 300 NPTG+ L +I + + P +LV+ DE Y E++ P H L Y+ + Sbjct: 166 NPTGNYIE---LADIQAFLDRVPSDVLVVLDEAYIEYVTPQPEKH---EKLVRTYKNLII 219 Query: 301 VNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAAL 351 FSK + + R+GY K I+ + ++ ++ +SI QK + A+ Sbjct: 220 TRTFSKIYGLASARVGYGIADKEIIRQLNIVRPPFNT--TSIGQKLAIEAI 268 >1UU1-A nrPDB Length = 335 Score = 51.6 bits (122), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 41/160 (25%), Positives = 75/160 (46%), Gaps = 17/160 (10%) Query: 235 LLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDM 294 ++ + +P+NPTG V+ + EEI RI+ K + L + YE S+ Sbjct: 141 VVFIPNPNNPTGHVFER---EEIERIL-KTGAFVALDEAYYEF------HGESYVDFLKK 190 Query: 295 YERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLG 354 YE + FSKAF++ R+GY+ + + A +++ ++ S ++Q AL Sbjct: 191 YENLAVIRTFSKAFSLAAQRVGYVVASEKFIDAYNRV--RLPFNVSYVSQMFAKVALD-- 246 Query: 355 KAGGETVAEMVKAYRERRDFLVKSLGDIKGVKISEPQGAF 394 E E K E R+ + +L ++ G +I++ +G F Sbjct: 247 --HREIFEERTKFIVEERERMKSALREM-GYRITDSRGNF 283 >3FTB-A nrPDB Length = 361 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 57/248 (22%), Positives = 108/248 (43%), Gaps = 20/248 (8%) Query: 152 ENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADATPVVIP 211 EN L I++ NGA + + ++ S ++++I P + Y A+ + V+ Sbjct: 71 ENYLKLKDIGIVLGNGASEIIELSI----SLFEKILIIVPSYAEYEINAKKHGVS--VVF 124 Query: 212 TKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLS 271 + + N +D +D+ SK+ + ++I +P+NP G + K + + +A+ + ++ Sbjct: 125 SYLDENMCIDYEDIISKIDDVDSVII-GNPNNPNGGLINKEKFIHVLK-LAEEKKKTIII 182 Query: 272 DEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGY-LAGPKHIVAACSK 330 DE + P+ +SF Y + +K FAM G R GY + K I A Sbjct: 183 DEAFIEFTGDPS--SSFVGEIKNYSCLFIIRAMTKFFAMPGIRFGYGITNNKEIAAKIKA 240 Query: 331 LQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFL--VKSLGDIKGVKIS 388 Q +I A +AA+ K ++ +ER+ F+ + +G IK ++ Sbjct: 241 KQ-----NPWNINCFAEMAAINCLKDTNYIEESLLWIKKERKRFIEELNKIGFIK--RVF 293 Query: 389 EPQGAFYL 396 P F L Sbjct: 294 SPHANFVL 301 >3FKD-A nrPDB Length = 350 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 68/314 (21%), Positives = 124/314 (39%), Gaps = 54/314 (17%) Query: 141 LREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQA 200 LR+ + ++ +N + ILV+NG + Q +A G +I P + Y + Sbjct: 55 LRQMLAKRNSVDN------NAILVTNGPTAAFYQ--IAQAFRGSRSLIAIPSFAEYEDAC 106 Query: 201 RLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARI 260 R+ + P+ +D+ LC+P+NP G + ++ EI R+ Sbjct: 107 RMYEHEVCFYPSN---------EDIGEADFSNMDFCWLCNPNNPDGRLLQRT---EILRL 154 Query: 261 IAKHPRLLVLSDEIY-----EHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRL 315 + HP + D+ Y E +I PA +L + V FS A+ + G R+ Sbjct: 155 LNDHPDTTFVLDQSYVSFTTEEVI-RPADIKGRKNL-------VMVYSFSHAYGIPGLRI 206 Query: 316 GYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFL 375 GY+ K + + + A +I AA + + + K R DF Sbjct: 207 GYIVANKDFMKRVAAFSTPWAVNALAIE-----AAKFILIHPAQFTLPIRKWQRNTVDF- 260 Query: 376 VKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVAMVPG 435 + +L + GV++ P G + + G+ AE L Y L+++ + + Sbjct: 261 ITALNRLDGVEV-HPSGTTFFLLRLKK--GTAAE----------LKKYMLEEYNMLIRDA 307 Query: 436 DAFG--DDSCIRIS 447 F D+S +RI+ Sbjct: 308 SNFRGLDESYVRIT 321 >6HNB-A nrPDB Length = 491 Score = 49.7 bits (117), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 63/279 (22%), Positives = 115/279 (41%), Gaps = 38/279 (13%) Query: 131 RYTLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPA 190 +Y G+ E + I + + Y ++VS G ++ + CS GD +++ Sbjct: 104 QYGSTFGLPEFLQFIKEHTDMVHKVPYENWDVIVSVGNTEAWDSTLRTFCSKGDTILVEE 163 Query: 191 PYWVSYTEQA--RLADATPVVIPTKISNNFLLDPKDLESKLT----EKSRLL-ILCSPSN 243 + S E A + + PV + + F + P+ LE ++ K + L +C+ N Sbjct: 164 YTFSSALESANGQGVNTVPVTM-----DEFGIIPEKLEELMSRWVGNKPKFLYTICTGQN 218 Query: 244 PTGSVYPKSLLEEIARIIAKHPRLLVLSDE---------------------IYEHIIYAP 282 PTGS ++I I K+ L++ DE +++H + Sbjct: 219 PTGSSLSAERRKQIYDIACKY-DFLIIEDEPYYFLQMETYTKDKAAREGKAVHDHDEFLK 277 Query: 283 ATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSI 342 A SF SL D+ R + ++ FSK A G RLG++ G K ++ +L S Sbjct: 278 ALVPSFISL-DVEGRVVRLDSFSKVLA-PGLRLGWIVGQKDLLERYVRLHEVSVQNPSGF 335 Query: 343 AQKAGVAAL-GLGKAGG-ETVAEMVKAYRERRDFLVKSL 379 ++ A L G +G + + + Y +RD + +L Sbjct: 336 SEALANALLRKWGHSGYLDWLIGLRAEYTHKRDVAIDAL 374 >3P1T-A nrPDB Length = 337 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 56/219 (25%), Positives = 90/219 (41%), Gaps = 36/219 (16%) Query: 236 LILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMY 295 ++L +PSNPTG L+++ + K +L DE Y ++SF + Y Sbjct: 139 VVLANPSNPTGQALSAGELDQLRQRAGK-----LLIDETY-------VDYSSFRARGLAY 186 Query: 296 -ERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLG 354 E L FSK++ + G RLG L GP ++AA + Q + G ++ A AAL Sbjct: 187 GENELVFRSFSKSYGLAGLRLGALFGPSELIAAMKRKQWFCNVG--TLDLHALEAALDND 244 Query: 355 KAGGETVAEMVKAYRERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLI 414 +A +A+ + R D L + L G +++ + F L + Sbjct: 245 RAREAHIAKTLAQRRRVADAL-RGL----GYRVASSEANFVL----------------VE 283 Query: 415 NDSSSLALYFLDKFQVAMVPGDAFGDDSCIRISYATSLD 453 N + L FL + + + FG IRIS D Sbjct: 284 NAAGERTLRFLRERGIQVKDAGQFGLHHHIRISIGREED 322 >2X5F-A nrPDB Length = 430 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 78/369 (21%), Positives = 157/369 (42%), Gaps = 62/369 (16%) Query: 137 GITELREAICRKLKEENGLSYAPDQI---LVSNGAKQSLLQAVLAVCSPGDEVIIPAPYW 193 GI ELR+ +K+ +N + D + +V+N L + D +++P W Sbjct: 89 GIEELRDLWQQKMLRDNP-ELSIDNMSRPIVTNALTHGLSLVGDLFVNQDDTILLPEHNW 147 Query: 194 VSYTEQARLADATPVVIPTKISNNFLLDP---KD-----------LESKLTEKSRLLILC 239 +Y +V T+ N P KD L+S +K ++IL Sbjct: 148 GNY----------KLVFNTRNGANLQTYPIFDKDGHYTTDSLVEALQSYNKDKV-IMILN 196 Query: 240 SPSNPTGSVYPK----SLLEEIARIIAKHPRLLVLSDEIYEHIIYAPA-THTSFASLPDM 294 P+NPTG +++E I + K +++ + D+ Y + Y T + F +L ++ Sbjct: 197 YPNNPTGYTPTHKEVTTIVEAIKALANKGTKVIAVVDDAYYGLFYEDVYTQSLFTALTNL 256 Query: 295 YERTL---TVNGFSKAFAMTGWRLGYLA------GPKHIVAACSKLQGQVSSGASS---I 342 + + ++G +K F G+R+G++ K ++ A K++G + S SS Sbjct: 257 HSNAILPIRLDGATKEFFAWGFRVGFMTFGTSDQTTKEVLEA--KVKGLIRSNISSGPLP 314 Query: 343 AQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSA 402 Q A L K + + + ++ +ER + K V ++ + + DF++ Sbjct: 315 TQSAVKHVLKNNKQFDKEIEQNIQTLKERYEV-------TKEVVYADQYHSHWQAYDFNS 367 Query: 403 YYGSEAEGFGLINDSSSLALYFLDKFQVAMVPGDAFGDDSCIRISYA-TSLDVLQAAVEK 461 Y + + D +L + +DK+ + ++ +A + IRI+++ D + + Sbjct: 368 GYFMAIKVHDV--DPEALRKHLIDKYSIGVIALNA----TDIRIAFSCVEKDDIPHVFDS 421 Query: 462 IRKALEPLR 470 I KA++ LR Sbjct: 422 IAKAIDDLR 430 >3NYS-A nrPDB Length = 367 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 39/121 (32%), Positives = 60/121 (49%), Gaps = 13/121 (10%) Query: 119 EAGIN-AIREGFTRYTLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQ-SLLQAV 176 +AGI +R G +Y L +TEL + +L + G Y I +NG ++Q Sbjct: 19 DAGIQRVLRHG--QYILGPEVTELED----RLADFVGAKYC---ISCANGTDALQIVQMA 69 Query: 177 LAVCSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLL 236 L V PGDEVI P +V+ E L A PV + + LDP+ LE+ +T +++ + Sbjct: 70 LGV-GPGDEVITPGFTYVATAETVALLGAKPVYVDID-PRTYNLDPQLLEAAITPRTKAI 127 Query: 237 I 237 I Sbjct: 128 I 128 >6HNV-A nrPDB Length = 524 Score = 42.0 bits (97), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 40/152 (26%), Positives = 65/152 (42%), Gaps = 16/152 (10%) Query: 293 DMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQK--AGVAA 350 D R L V FSK FA G RLG++ G K ++ A V+ GAS + Q V Sbjct: 328 DTTGRVLRVETFSKLFA-PGLRLGFIVGHKEVIDAVKNYSDVVNRGASGLTQTIVNNVIQ 386 Query: 351 LGLGKAGG--ETVAEMVKAYRERRDFLVKSLGDIKGVK-----ISEPQGAFYLFIDFSAY 403 G E + +M Y R+D L+ S+ + + K + +P+ +F+ F Sbjct: 387 ENFKGVDGWLEWILKMRLNYSYRKDLLLYSIFESQAYKKGYVDVIDPKAG--MFVTFKIN 444 Query: 404 YGSEAEGFGLINDSSSLALYFLDKFQVAMVPG 435 + + + L L+ L + + +VPG Sbjct: 445 LPKDVD----VLQKMKLLLWKLISYGILVVPG 472 >1LC8-A nrPDB Length = 364 Score = 42.0 bits (97), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 34/123 (27%), Positives = 55/123 (44%), Gaps = 5/123 (4%) Query: 229 LTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSF 288 LT L LC+P+NPTG + + LL+ IA L+L + + I + + Sbjct: 143 LTPDLDCLFLCTPNNPTGLLPERPLLQAIADRCKSLNINLILDEAFIDFIPHETGFIPAL 202 Query: 289 ASLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGV 348 P ++ + +K +A+ G RLGYL A + Q Q+ +++A AG Sbjct: 203 KDNPHIW----VLRSLTKFYAIPGLRLGYLVNSDDAAMARMRRQ-QMPWSVNALAALAGE 257 Query: 349 AAL 351 AL Sbjct: 258 VAL 260 >2C81-A nrPDB Length = 418 Score = 42.0 bits (97), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 27/95 (28%), Positives = 53/95 (55%), Gaps = 8/95 (8%) Query: 183 GDEVIIPAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCSPS 242 GDEVI+P+ W++ +A PV + + ++ + +DP+ ++S +T+K++ +I P Sbjct: 82 GDEVIVPSLTWIATATAVLNVNALPVFVDVE-ADTYCIDPQLIKSAITDKTKAII---PV 137 Query: 243 NPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEH 277 + GS+ + ++EI I +H L V+ D H Sbjct: 138 HLFGSM---ANMDEINEIAQEH-NLFVIEDCAQSH 168 >3UWC-A nrPDB Length = 374 Score = 41.6 bits (96), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 29/105 (27%), Positives = 55/105 (52%), Gaps = 5/105 (4%) Query: 155 LSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKI 214 L AP I V G + + GDEVI A +++ A ATPV++ ++ Sbjct: 50 LHNAPHAIGVGTGTDALAMSFKMLNIGAGDEVITCANTFIASVGAIVQAGATPVLVDSE- 108 Query: 215 SNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIAR 259 N +++DP+ +E+ +T+K++ ++ P + TG++ L +IA+ Sbjct: 109 -NGYVIDPEKIEAAITDKTKAIM---PVHYTGNIADMPALAKIAK 149 >3DR4-A nrPDB Length = 391 Score = 41.6 bits (96), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 32/111 (28%), Positives = 53/111 (47%), Gaps = 8/111 (7%) Query: 162 ILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNNFLLD 221 I +NG L V PGDEVI+P+ +++ ATPV++ F LD Sbjct: 75 IACNNGTTALHLALVAMGIGPGDEVIVPSLTYIASANSVTYCGATPVLVDND-PRTFNLD 133 Query: 222 PKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSD 272 LE+ +T +++ ++ P + G + + E+AR +H LLV+ D Sbjct: 134 AAKLEALITPRTKAIM---PVHLYGQICDMDPILEVAR---RH-NLLVIED 177 >4WBT-A nrPDB Length = 376 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 46/184 (25%), Positives = 76/184 (41%), Gaps = 24/184 (13%) Query: 140 ELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQ 199 +L++A+ R L +P I + G L Q V V G V+ + ++ Sbjct: 75 DLKQALARHL------GTSPANIAIGEGIDGLLGQIVRLVVEAGAPVVTSLGGYPTFNYH 128 Query: 200 ARLADATPVVIPTKISNNFLLDPKDLESKLT----EKSRLLILCSPSNPTGSVYPKSLLE 255 V +P + D +DLE L E + L+ L +P NP GS +P + Sbjct: 129 VAGHGGRLVTVP------YADDREDLEGLLAAVGRENAPLVYLANPDNPMGSWWPAERVV 182 Query: 256 EIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYER--TLTVNGFSKAFAMTGW 313 A+ + + LLVL DE Y A + + + ++ + FSKA+ + G Sbjct: 183 AFAQALPET-TLLVL-DEAYCET----APRDALPPIESLIDKPNVIRARTFSKAYGLAGA 236 Query: 314 RLGY 317 R+GY Sbjct: 237 RIGY 240 >3G7Q-A nrPDB Length = 417 Score = 39.7 bits (91), Expect = 0.003, Method: Compositional matrix adjust. Identities = 80/362 (22%), Positives = 135/362 (37%), Gaps = 83/362 (22%) Query: 150 KEENGLSYAPDQILVSNGAKQSL-----LQAVLAVCSPGDEVIIP-APYWVSYTEQARLA 203 +E G P I ++NG++ + L A +V+ P AP ++ Y + Sbjct: 89 RETLGWDIEPQNIALTNGSQSAFFYLFNLFAGRRADGSTKKVLFPLAPEYIGYADSGLED 148 Query: 204 DATPVVIPTKISNNFLLDPK-------DLES-KLTEKSRLLILCSPSNPTGSVYPKSLLE 255 D P N L P+ D E + E++ ++ + P+NPTG+V L Sbjct: 149 DLFVSARP-----NIELLPEGQFKYHVDFEHLHIGEETGMICVSRPTNPTGNVITDEELM 203 Query: 256 EIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRL 315 ++ R+ +H LV+ D Y P F+ ++ + + + G R Sbjct: 204 KLDRLANQHNIPLVI-DNAYG----VPFPGIIFSEARPLWNPNIILCMSLSKLGLPGSRC 258 Query: 316 GYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFL 375 G I+ A K ++IA G+ +L G G + EM+K R D L Sbjct: 259 G-------IIIANDKT-------ITAIANMNGIISLAPGGMGPAMMCEMIK----RNDLL 300 Query: 376 VKSLGDIKGVK---------------------ISEPQGAFYLFIDFSAYYGSEAEGFGLI 414 S IK I +P+GA +L++ F + Sbjct: 301 RLSETVIKPFYYQRVQQTIAIIRRYLSEERCLIHKPEGAIFLWLWFKD-----------L 349 Query: 415 NDSSSLALYFLDKFQVAMVPGDAF--GDD-------SCIRISYATSLDVLQAAVEKIRKA 465 ++ L L V MVPG F G D C+R++Y D ++A V+ + + Sbjct: 350 PITTELLYQRLKARGVLMVPGHYFFPGLDKPWPHTHQCMRMNYVPEPDKIEAGVKILAEE 409 Query: 466 LE 467 +E Sbjct: 410 IE 411 >4JE5-A nrPDB Length = 503 Score = 39.7 bits (91), Expect = 0.003, Method: Compositional matrix adjust. Identities = 65/285 (22%), Positives = 118/285 (41%), Gaps = 45/285 (15%) Query: 131 RYTLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPA 190 +Y +AG EL I K + L Y +L + G + + C+ GD +++ A Sbjct: 107 QYGFSAGQPELLNFIRDHTKIIHDLKYKDWDVLATAGNTNAWESTLRVFCNRGDVILVEA 166 Query: 191 PYWVSYTEQARLADATPVV-IPTKISNNFLLDPKDLESKLTE-------KSRLL-ILCSP 241 S++ A+A V+ P I + ++ P+ L +K+ E K +LL + + Sbjct: 167 ---HSFSSSLASAEAQGVITFPVPIDADGII-PEKL-AKVMENWTPGAPKPKLLYTIPTG 221 Query: 242 SNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIY------------------------EH 277 NPTG+ E I +I K+ L++ DE Y +H Sbjct: 222 QNPTGTSIADHRKEAIYKIAQKY-DFLIVEDEPYYFLQMNPYIKDLKEREKAQSSPKQDH 280 Query: 278 IIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVA---ACSKLQGQ 334 + + +F SL D R + ++ FSK A G RLG++ G I+ + ++ Q Sbjct: 281 DEFLKSLANTFLSL-DTEGRVIRMDSFSKVLA-PGTRLGWITGSSKILKPYLSLHEMTIQ 338 Query: 335 VSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSL 379 +G + + A ++ G K + + + Y +RD + +L Sbjct: 339 APAGFTQVLVNATLSRWG-QKGYLDWLLGLRHEYTLKRDCAIDAL 382 >5K8B-A nrPDB Length = 403 Score = 37.7 bits (86), Expect = 0.010, Method: Compositional matrix adjust. Identities = 38/157 (24%), Positives = 72/157 (45%), Gaps = 23/157 (14%) Query: 123 NAIREGFT-RYTLNA------GITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQA 175 + + GFT RY + ++ + +C K+ ++ L+S+G Sbjct: 17 DVMEHGFTFRYNFDHMRNDRWKTRDMEQLLCEKMNVKHAH-------LLSSGTAALQTAM 69 Query: 176 VLAVCSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRL 235 + A GDEVI+P +V+ E +A A P+ +I L P+ +E+ +T +++ Sbjct: 70 MAAGIGAGDEVIVPPFTFVASVEAIFMAGAVPIF--AEIDETLCLSPEGIEAVITPRTKA 127 Query: 236 LILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSD 272 + L + GS+ + ++EI I KH L++L D Sbjct: 128 INLV---HMCGSM---AKMDEIKAICKKH-NLVLLED 157 >1MDZ-A nrPDB Length = 393 Score = 37.4 bits (85), Expect = 0.015, Method: Compositional matrix adjust. Identities = 30/99 (30%), Positives = 50/99 (50%), Gaps = 10/99 (10%) Query: 140 ELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAV-CSPGDEVIIPAPYWVSYTE 198 EL A CR G YA + VS+ A + A++A+ GDEVI P+ WVS Sbjct: 43 ELEAAFCRL----TGNQYA---VAVSS-ATAGMHIALMALGIGEGDEVITPSMTWVSTLN 94 Query: 199 QARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLI 237 L A PV++ + ++ P+ +E+ +T +++ +I Sbjct: 95 MIVLLGANPVMVDVD-RDTLMVTPEHIEAAITPQTKAII 132 >5DJ3-A nrPDB Length = 376 Score = 37.4 bits (85), Expect = 0.015, Method: Compositional matrix adjust. Identities = 52/254 (20%), Positives = 96/254 (37%), Gaps = 22/254 (8%) Query: 220 LDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHII 279 L DL ++L + + +P+NPTG V + L +A A+H +L L Sbjct: 137 LHGADLSAELLSSVGCVFVTTPNNPTGRVLAEERLRRLAEQCAEHGTVLALDTSFRG--F 194 Query: 280 YAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGA 339 A A + +A L + R + + K + + G L + I K+ + G Sbjct: 195 DAAAHYDHYAVLQEAGCRWVVIEDTGKLWPTLDLKAGLLVFSEDIGLPVEKIYSDILLGV 254 Query: 340 SSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLGDIKGVKISEPQGAFYLFID 399 S + A + A G +A++ R + ++L ++GV +P+ Sbjct: 255 SPLI-LALIREFSRDAADG-GLADLHAFILHNRSVVRRALAGVEGVSFPDPESR------ 306 Query: 400 FSAYYGSEAEGFGLINDSSSLALYFLDKFQVAMVPGDAF------GDDSCIRISYATSLD 453 S E + + L + V +P F D +RI+ + S + Sbjct: 307 ------SSVERVAFAGRTGTEVWEELQRHHVFALPCRQFHWAEPSDGDHMVRIALSRSTE 360 Query: 454 VLQAAVEKIRKALE 467 L+ +V+ +R LE Sbjct: 361 PLEKSVQVLRTVLE 374 >3IF2-A nrPDB Length = 444 Score = 36.6 bits (83), Expect = 0.028, Method: Compositional matrix adjust. Identities = 53/244 (21%), Positives = 101/244 (41%), Gaps = 24/244 (9%) Query: 237 ILCS-PSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEI---YEHIIYAPATHTSFASLP 292 I CS P+NPTG+V + +A I ++ L++ + + +IIY+ A H ++ + Sbjct: 210 ICCSRPTNPTGNVLTDEEMAHLAEIAKRYDIPLIIDNAYGMPFPNIIYSDA-HLNWDN-- 266 Query: 293 DMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALG 352 T+ SK + G R G + ++ A S + V+ + + Sbjct: 267 ----NTILCFSLSK-IGLPGMRTGIIVADAKVIEAVSAMNAVVNLAPTRFGAAIATPLVA 321 Query: 353 LGKAGGETVAEMVKAYRERRDFLVK----SLGDIKGVKISEPQGAFYLFIDFSAYYGSEA 408 + + E+ Y+++ VK +LGD + I +P+GA +L++ F S Sbjct: 322 NDRIKQLSDNEIKPFYQKQATLAVKLLKQALGDYP-LMIHKPEGAIFLWLWFKDLPISTL 380 Query: 409 EGFGLINDSSSLAL---YFLDKFQVAMVPGDAFGDDSCIRISYATSLDVLQAAVEKIRKA 465 + + + +L + YF V+ D CIR+S A L ++ I + Sbjct: 381 DLYERLKAKGTLIVPSEYFFPGVDVS----DYQHAHECIRMSIAADEQTLIDGIKVIGEV 436 Query: 466 LEPL 469 + L Sbjct: 437 VREL 440 >5W70-A nrPDB Length = 445 Score = 34.3 bits (77), Expect = 0.12, Method: Compositional matrix adjust. Identities = 22/92 (23%), Positives = 40/92 (43%), Gaps = 4/92 (4%) Query: 147 RKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADAT 206 R NG+ P + ++G +L GDEVI+P WV+ +A Sbjct: 80 RAFAAYNGV---PHCVPAASGTASLMLALEACGIGAGDEVIVPGLSWVASGSTILGVNAV 136 Query: 207 PVVIPTKISNNFLLDPKDLESKLTEKSRLLIL 238 P+ + L P+ +E+ +TE +R +++ Sbjct: 137 PIFCDVD-PDTLCLSPEAVEAAITEHTRAIVV 167 >4ZWV-A nrPDB Length = 372 Score = 34.3 bits (77), Expect = 0.14, Method: Compositional matrix adjust. Identities = 57/232 (24%), Positives = 91/232 (39%), Gaps = 28/232 (12%) Query: 184 DEVIIPAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCSPSN 243 DEV+ P T A LAD + +D DLE K++ +R +I+ + Sbjct: 75 DEVL-STPLTFEATNWAILADGRRITWVDVDPATLTMDLDDLERKISPATRAIIVV---H 130 Query: 244 PTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNG 303 TG YP L + +A I+ + R + E +A S+ +P + V Sbjct: 131 WTG--YPVDL-DRLAGILDRAEREHGFRPAVIEDCAHAWGA--SYRGVPLGSHGNMCVFS 185 Query: 304 FSKAFAMTGWRLGYLAGPK---HIVAACSKLQGQVSSGASSIAQKAGVAALGL------- 353 F +T G L P H A + G + A + VA GL Sbjct: 186 FQALKHLTCGDGGLLTLPGDELHERAMLRRFYG-IDRTADRLRGAYDVAEWGLKWHMTDL 244 Query: 354 ----GKAGGETVAEMVKAYRERRDFLVKSLGDIKGVKI----SEPQGAFYLF 397 G A ETV E ++ +RE F K L + G+++ + +G+FY++ Sbjct: 245 NAAIGLANLETVDEQLRLHRENAAFYDKELTGVPGLELLQRSPDREGSFYVY 296 >4PIW-A nrPDB Length = 396 Score = 33.5 bits (75), Expect = 0.18, Method: Compositional matrix adjust. Identities = 24/93 (25%), Positives = 49/93 (52%), Gaps = 5/93 (5%) Query: 146 CRKLKEENGLSYAPDQILVSNGAKQSL-LQAVLAVCSPGDEVIIPAPYWVSYTEQARLAD 204 C++ E+ + ++L++ SL + A+L PGDEVI+P+ +VS L Sbjct: 56 CQQWLEQR---FGSAKVLLTPSCTASLEMAALLLDIQPGDEVIMPSYTFVSTANAFVLRG 112 Query: 205 ATPVVIPTKISNNFLLDPKDLESKLTEKSRLLI 237 A V + + + +D +E+ +T+K+R+++ Sbjct: 113 AKIVFVDVR-PDTMNIDETLIEAAITDKTRVIV 144 >1TAR-A nrPDB Length = 401 Score = 33.5 bits (75), Expect = 0.18, Method: Compositional matrix adjust. Identities = 37/139 (26%), Positives = 60/139 (43%), Gaps = 10/139 (7%) Query: 185 EVIIPAPYWVSYTEQARLA----DATPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCS 240 +V +P P W ++T R A A P S +F +D+ SK+ EKS +L+ Sbjct: 125 DVYLPKPSWGNHTPIFRDAGLQLQAYRYYDPKTCSLDFTGAMEDI-SKIPEKSIILLHAC 183 Query: 241 PSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLT 300 NPTG + +E+A ++ K LL D Y+ ++A L E+ + Sbjct: 184 AHNPTGVDPRQEQWKELASVVKKR-NLLAYFDMAYQGFASGDINRDAWA-LRHFIEQGID 241 Query: 301 V---NGFSKAFAMTGWRLG 316 V ++K + G R G Sbjct: 242 VVLSQSYAKNMGLYGERAG 260 >4K2M-A nrPDB Length = 443 Score = 33.5 bits (75), Expect = 0.21, Method: Compositional matrix adjust. Identities = 31/113 (27%), Positives = 56/113 (49%), Gaps = 11/113 (9%) Query: 162 ILVSNGAKQSLLQAVLAV-CSPGDEVIIPAPYWVSYTEQARLAD-ATPVVIPTKISNNFL 219 ++ ++ +++ +LA+ +PGDEVI+PA + S TE A LA P+ + F Sbjct: 121 VIATSSGTDAIMIGLLALGLNPGDEVIMPANSF-SATENAVLASGGVPIYVDIN-PQTFC 178 Query: 220 LDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSD 272 +DP +E +T ++ ++ P S ++ I R IA +L V+ D Sbjct: 179 IDPDKIEEAITPYTKFIL------PVHLYGKHSDMQHI-RQIANRYKLKVIED 224 >3FED-A nrPDB Length = 707 Score = 33.1 bits (74), Expect = 0.26, Method: Compositional matrix adjust. Identities = 18/61 (29%), Positives = 29/61 (47%), Gaps = 8/61 (13%) Query: 274 IYEHIIYAPATHTSFA--SLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKL 331 Y HII+AP++H +A S P +Y+ + + + RL + KHI A + Sbjct: 643 FYRHIIFAPSSHNKYAGESFPGIYDAIFDIENKANS------RLAWKEVKKHISIAAFTI 696 Query: 332 Q 332 Q Sbjct: 697 Q 697 >1M6S-A nrPDB Length = 347 Score = 32.7 bits (73), Expect = 0.40, Method: Compositional matrix adjust. Identities = 26/100 (26%), Positives = 43/100 (43%), Gaps = 13/100 (13%) Query: 175 AVLAVCSPGDEVIIPAP---YWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTE 231 +++A GDEVI+ A +W A L+ P +P K N +DP D+ + Sbjct: 69 SIMAHTQRGDEVILEADSHIFWYEVGAMAVLSGVMPHPVPGK---NGAMDPDDVRKAIRP 125 Query: 232 K-------SRLLILCSPSNPTGSVYPKSLLEEIARIIAKH 264 + S + I + + G V P ++EI I +H Sbjct: 126 RNIHFPRTSLIAIENTHNRSGGRVVPLENIKEICTIAKEH 165 >4WD2-A nrPDB Length = 408 Score = 32.3 bits (72), Expect = 0.46, Method: Compositional matrix adjust. Identities = 30/116 (25%), Positives = 51/116 (43%), Gaps = 6/116 (5%) Query: 229 LTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSF 288 L +S +L+ NPTG + E++ +I LL D Y+ + Sbjct: 177 LPARSIVLLHACCHNPTGVDLDEGQWEKLIDVIEAR-ELLPFVDMAYQG--FGAGLDADA 233 Query: 289 ASLPDMYER---TLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASS 341 ++ ++ R TL N FSK F++ G R+G L+ AA ++ GQ++ S Sbjct: 234 FAVRELARRGVPTLVANSFSKNFSLYGERVGGLSVVCEDAAAAERVLGQLAGAVRS 289 >4W91-A nrPDB Length = 422 Score = 32.0 bits (71), Expect = 0.54, Method: Compositional matrix adjust. Identities = 24/114 (21%), Positives = 53/114 (46%), Gaps = 22/114 (19%) Query: 160 DQILVSNGAKQSLLQAVLAVCSP----GDEV----------IIPAPYWVSYTEQARLADA 205 D+I+ + A +++ P GDE+ I+P +++ + A+L Sbjct: 102 DEIVFTKNATEAINTVAYGYGMPFIGEGDEILLSIMEHHSNIVPW-HFIRERQGAKL--- 157 Query: 206 TPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIAR 259 + T + +N + ++ E +L+E+++L+ + SN G+V P + E+A Sbjct: 158 ----VFTPVDDNGVFHIEEFEKRLSERTKLVAITHMSNTLGTVVPIKKIVELAH 207 >2OGE-A nrPDB Length = 399 Score = 32.0 bits (71), Expect = 0.64, Method: Compositional matrix adjust. Identities = 18/56 (32%), Positives = 31/56 (55%), Gaps = 1/56 (1%) Query: 182 PGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLI 237 PGDEVI+P+ +++ ATPV + ++ LDP +E +T ++R L+ Sbjct: 102 PGDEVIVPSHTYIASWLAVSATGATPVPVEPH-EDHPTLDPLLVEKAITPRTRALL 156 >1B9H-A nrPDB Length = 388 Score = 32.0 bits (71), Expect = 0.64, Method: Compositional matrix adjust. Identities = 20/75 (26%), Positives = 42/75 (56%), Gaps = 3/75 (4%) Query: 164 VSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKI-SNNFLLDP 222 V+NG L + PG EVI+PA ++S ++ A+ A V +P + + + LDP Sbjct: 59 VTNGTHALELALQVMGVGPGTEVIVPAFTFISSSQAAQRLGA--VTVPVDVDAATYNLDP 116 Query: 223 KDLESKLTEKSRLLI 237 + + + +T ++++++ Sbjct: 117 EAVAAAVTPRTKVIM 131 >3MEB-A nrPDB Length = 448 Score = 31.6 bits (70), Expect = 0.73, Method: Compositional matrix adjust. Identities = 30/107 (28%), Positives = 46/107 (42%), Gaps = 8/107 (7%) Query: 223 KDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAP 282 KD++S EKS L NP+G + ++ +E+ I+ K + + D Y+ Sbjct: 194 KDIQSA-PEKSIFLFHACAHNPSGIDFTEAQWKELLPIM-KEKKHIAFFDSAYQGFATGS 251 Query: 283 ATHTSFA--SLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAA 327 +FA D L FSK F + G R+G L H+V A Sbjct: 252 FEADAFAVRMFVDAGVEVLVAQSFSKNFGLYGERIGCL----HVVHA 294 >6BLG-A nrPDB Length = 379 Score = 31.2 bits (69), Expect = 1.0, Method: Compositional matrix adjust. Identities = 19/65 (29%), Positives = 35/65 (53%), Gaps = 1/65 (1%) Query: 173 LQAVLAVCSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEK 232 + A+L PGDEVI+P+ +VS L A V + + + +D +E+ +T+K Sbjct: 64 MAALLLDIQPGDEVIMPSYTFVSTANAFVLRGAKIVFVDIR-RDTMNIDETLIEAAITDK 122 Query: 233 SRLLI 237 +R ++ Sbjct: 123 TRAIV 127 >3G0T-A nrPDB Length = 437 Score = 31.2 bits (69), Expect = 1.1, Method: Compositional matrix adjust. Identities = 58/253 (22%), Positives = 94/253 (37%), Gaps = 29/253 (11%) Query: 87 ITDLAATLVQ----SGVPVIRLAAGEPDFDTPKVVAEAGINAIREGFTRYTLNA-GITEL 141 I DL A + +G R+ G P P++ E I +REG N G+ EL Sbjct: 28 IRDLVALVTNLEKATGTKFCRMEMGVPGLPAPQIGIETEIQKLREGVASIYPNLDGLPEL 87 Query: 142 REAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQA- 200 ++ R K + + + G+ Q + L + Y + + Sbjct: 88 KQEASRFAKLFVNIDIPARACVPTVGSMQGCFVSFLVA----NRTHKNREYGTLFIDPGF 143 Query: 201 RLADATPVVIPTKISNNFLLDPK------DLESKL-TEKSRLLILCSPSNPTGSVYPKSL 253 L ++ K + L + + LES L T + +I +P+NPT Sbjct: 144 NLNKLQCRILGQKFESFDLFEYRGEKLREKLESYLQTGQFCSIIYSNPNNPTWQCMTDEE 203 Query: 254 LEEIARIIAKHPRLLVLSDEIYEHIIY--------APATHTSFASLPDMYERTLTVNGFS 305 L I + KH ++V+ D Y + + P S A+ D Y L+ S Sbjct: 204 LRIIGELATKHD-VIVIEDLAYFGMDFRKDYSHPGEPLYQPSVANYTDNYILALSS---S 259 Query: 306 KAFAMTGWRLGYL 318 KAF+ G R+G L Sbjct: 260 KAFSYAGQRIGVL 272 >6CJB-A nrPDB Length = 391 Score = 30.8 bits (68), Expect = 1.4, Method: Compositional matrix adjust. Identities = 19/54 (35%), Positives = 34/54 (62%), Gaps = 4/54 (7%) Query: 222 PKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIY 275 P+++E+ +T K++LL L +PSNP + + L +IA IAK L+ ++D + Sbjct: 136 PENIEAAITPKTKLLWLETPSNP---MLKLANLRKIA-AIAKKYNLITVADNTF 185 >5ILB-A nrPDB Length = 474 Score = 30.8 bits (68), Expect = 1.4, Method: Compositional matrix adjust. Identities = 26/103 (25%), Positives = 46/103 (44%), Gaps = 7/103 (6%) Query: 28 GSVRFQQPLRLSFSYCKSGNMSSRICAMAKPNDAETLSSSVDMSLSPRV----QSLKPSK 83 G+V F+ R+ FSY S + + + E L ++ +++ R+ S KP Sbjct: 273 GTVPFRHGERIGFSYLISQKYTGDSALVKVLRNKEILEFNIKLAIHKRLIPAHISGKPPS 332 Query: 84 TMVITDLAATLVQSGVPVIRLAAG-EPDFDTPKVVAEAGINAI 125 ++ T V VP +R G E +FD P + E ++A+ Sbjct: 333 YFIVAGFVFTTVS--VPYLRSEYGKEYEFDAPVKLLEKHLHAM 373 >3JCM-G nrPDB Length = 899 Score = 30.8 bits (68), Expect = 1.5, Method: Compositional matrix adjust. Identities = 12/47 (25%), Positives = 23/47 (48%) Query: 370 ERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLIND 416 E RDF ++ ++ KIS + +Y +++F Y E +N+ Sbjct: 612 ELRDFFQQTFSSLEDFKISGTERLYYKYVNFLRYQDLNEEAIKFLNE 658 >4MCR-A nrPDB Length = 757 Score = 30.4 bits (67), Expect = 1.5, Method: Compositional matrix adjust. Identities = 11/30 (36%), Positives = 18/30 (60%), Gaps = 2/30 (6%) Query: 274 IYEHIIYAPATHTSFA--SLPDMYERTLTV 301 Y H+IYAP++H +A S P +Y+ + Sbjct: 693 FYRHVIYAPSSHNKYAGESFPGIYDALFDI 722 >5JYK-A nrPDB Length = 566 Score = 30.0 bits (66), Expect = 2.4, Method: Compositional matrix adjust. Identities = 26/103 (25%), Positives = 46/103 (44%), Gaps = 7/103 (6%) Query: 28 GSVRFQQPLRLSFSYCKSGNMSSRICAMAKPNDAETLSSSVDMSLSPRV----QSLKPSK 83 G+V F+ R+ FSY S + + + E L ++ +++ R+ S KP Sbjct: 365 GTVPFRHGERIGFSYLISQKYTGDSALVKVLRNKEILEFNIKLAIHKRLIPAHISGKPPS 424 Query: 84 TMVITDLAATLVQSGVPVIRLAAG-EPDFDTPKVVAEAGINAI 125 ++ T V VP +R G E +FD P + E ++A+ Sbjct: 425 YFIVAGFVFTTVS--VPYLRSEYGKEYEFDAPVKLLEKHLHAM 465 >6J9S-A nrPDB Length = 326 Score = 28.1 bits (61), Expect = 9.2, Method: Compositional matrix adjust. Identities = 20/43 (46%), Positives = 27/43 (62%), Gaps = 4/43 (9%) Query: 357 GGETVAEMVKAYRE-RRDFLVKSLGDI--KGVKISEPQGA-FY 395 GG T+AE VKA+ E + D LVK D+ K +I + +GA FY Sbjct: 195 GGVTIAEWVKAHPEIKEDKLVKMFEDVRNKAYEIIKLKGATFY 237 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 5WMH-A nrPDB 659 0.0 6F77-B nrPDB 419 e-118 1J32-A nrPDB 410 e-115 6F35-A nrPDB 406 e-113 1GDE-A nrPDB 397 e-111 1O4S-A nrPDB 388 e-108 1GC4-A nrPDB 386 e-107 1XI9-A nrPDB 359 1e-99 2Z61-A nrPDB 350 6e-97 4WP0-A nrPDB 334 7e-92 3FVS-A nrPDB 334 7e-92 2X5D-A nrPDB 328 3e-90 4MY5-A nrPDB 325 2e-89 1U08-A nrPDB 323 1e-88 2ZJG-A nrPDB 322 2e-88 1YIY-A nrPDB 312 2e-85 2O0R-A nrPDB 308 3e-84 5YHV-A nrPDB 308 4e-84 3H14-A nrPDB 303 1e-82 3DYD-A nrPDB 300 1e-81 3PDX-A nrPDB 299 2e-81 1V2E-A nrPDB 293 1e-79 4CVQ-A nrPDB 291 6e-79 4DQ6-A nrPDB 288 3e-78 3L8A-A nrPDB 285 3e-77 5Z0Q-C nrPDB 282 2e-76 3T32-A nrPDB 280 9e-76 2O1B-A nrPDB 279 1e-75 3B1C-A nrPDB 279 2e-75 3B46-A nrPDB 278 3e-75 4IX8-A nrPDB 277 7e-75 2GB3-A nrPDB 276 1e-74 3FDB-A nrPDB 276 2e-74 1BW0-A nrPDB 274 5e-74 3ASB-A nrPDB 273 1e-73 2ZC0-A nrPDB 271 6e-73 1C7O-A nrPDB 269 2e-72 3ELE-A nrPDB 268 3e-72 3QGU-A nrPDB 260 8e-70 2DOU-A nrPDB 257 7e-69 4FL0-A nrPDB 255 3e-68 3JTX-A nrPDB 254 6e-68 3AV7-A nrPDB 249 2e-66 1X0M-A nrPDB 248 5e-66 3OP7-A nrPDB 243 2e-64 3DZZ-A nrPDB 240 1e-63 1IAY-A nrPDB 232 3e-61 3EI8-A nrPDB 230 8e-61 3IHJ-A nrPDB 226 1e-59 1D2F-A nrPDB 221 4e-58 2ZYJ-A nrPDB 216 1e-56 4M2J-A nrPDB 213 2e-55 1M4N-A nrPDB 213 2e-55 3TCM-A nrPDB 207 8e-54 3EZS-A nrPDB 206 1e-53 3NRA-A nrPDB 206 2e-53 4GDY-A nrPDB 200 1e-51 4R2N-A nrPDB 194 8e-50 1IJI-A nrPDB 193 2e-49 3CQ5-A nrPDB 191 7e-49 3GET-A nrPDB 187 8e-48 6HNB-A nrPDB 179 3e-45 3FKD-A nrPDB 176 2e-44 4RAE-A nrPDB 173 1e-43 3HDO-A nrPDB 170 1e-42 2X5F-A nrPDB 165 4e-41 6HNV-A nrPDB 165 5e-41 3FFH-A nrPDB 164 9e-41 1UU1-A nrPDB 160 1e-39 3EUC-A nrPDB 157 1e-38 3LY1-A nrPDB 156 3e-38 5X03-B nrPDB 152 4e-37 4N0B-A nrPDB 152 4e-37 2ZY3-A nrPDB 151 7e-37 3F6T-A nrPDB 150 1e-36 3FTB-A nrPDB 149 2e-36 3FDD-A nrPDB 149 2e-36 2ZY2-A nrPDB 148 6e-36 4WBT-A nrPDB 147 8e-36 1LC8-A nrPDB 145 4e-35 3P1T-A nrPDB 139 3e-33 3UWC-A nrPDB 84 1e-16 3DR4-A nrPDB 84 1e-16 3NYS-A nrPDB 82 5e-16 2C81-A nrPDB 81 1e-15 Sequences not found previously or not previously below threshold: 1WST-A nrPDB 226 2e-59 1VP4-A nrPDB 198 6e-51 4JE5-A nrPDB 155 5e-38 3IF2-A nrPDB 134 8e-32 3G7Q-A nrPDB 125 3e-29 3G0T-A nrPDB 118 5e-27 4EMY-A nrPDB 111 6e-25 5DJ3-A nrPDB 99 3e-21 3RQ1-A nrPDB 99 5e-21 3BWN-A nrPDB 92 4e-19 3EZ1-A nrPDB 87 2e-17 1AY8-A nrPDB 86 4e-17 4K2M-A nrPDB 83 2e-16 3FSL-A nrPDB 83 2e-16 4F5M-A nrPDB 83 3e-16 6C3C-A nrPDB 80 2e-15 4WD2-A nrPDB 79 3e-15 5IWQ-A nrPDB 77 2e-14 4W5K-A nrPDB 76 4e-14 4PIW-A nrPDB 76 5e-14 2OGE-A nrPDB 72 4e-13 6BLG-A nrPDB 72 6e-13 4WB0-B nrPDB 72 6e-13 5VPR-A nrPDB 71 1e-12 3PD6-B nrPDB 69 5e-12 4ZWV-A nrPDB 69 5e-12 5C6U-A nrPDB 67 1e-11 3VK2-A nrPDB 67 1e-11 1MDZ-A nrPDB 67 2e-11 2HOR-A nrPDB 67 2e-11 4RKC-A nrPDB 65 8e-11 1M6S-A nrPDB 64 2e-10 1B9H-A nrPDB 64 2e-10 1TAR-A nrPDB 64 2e-10 5XT5-A nrPDB 64 2e-10 4H51-A nrPDB 63 2e-10 1T3I-A nrPDB 63 3e-10 5W70-A nrPDB 63 3e-10 4EFF-A nrPDB 62 6e-10 5U24-A nrPDB 61 9e-10 3II0-A nrPDB 61 1e-09 3MEB-A nrPDB 61 1e-09 5K8B-A nrPDB 61 1e-09 2GMS-A nrPDB 61 2e-09 1PFF-A nrPDB 60 2e-09 6EZL-A nrPDB 59 3e-09 2X8U-A nrPDB 59 4e-09 6ONN-A nrPDB 59 6e-09 6C9E-A nrPDB 58 9e-09 1YAA-A nrPDB 58 9e-09 5TSU-A nrPDB 58 1e-08 3BB8-A nrPDB 57 2e-08 3QI6-A nrPDB 57 2e-08 2CST-A nrPDB 57 2e-08 5TON-A nrPDB 56 3e-08 3K7Y-A nrPDB 56 4e-08 1CS1-A nrPDB 56 6e-08 6MRE-A nrPDB 55 6e-08 4QGR-A nrPDB 55 8e-08 1IBJ-A nrPDB 54 1e-07 6CJB-A nrPDB 53 3e-07 3LVM-A nrPDB 53 3e-07 3WGB-A nrPDB 53 3e-07 4L0O-H nrPDB 52 6e-07 5X5H-A nrPDB 52 7e-07 5IJG-A nrPDB 50 1e-06 1N8P-A nrPDB 50 3e-06 4OC9-A nrPDB 50 3e-06 4BMK-A nrPDB 50 3e-06 5W1B-A nrPDB 49 4e-06 4IYO-A nrPDB 49 4e-06 5WGB-A nrPDB 49 6e-06 4U1T-A nrPDB 47 2e-05 3N0L-A nrPDB 47 2e-05 3G8M-A nrPDB 47 3e-05 4GSA-A nrPDB 45 5e-05 3GBX-A nrPDB 45 7e-05 4P3M-A nrPDB 45 1e-04 1WYV-B nrPDB 44 1e-04 3ISL-A nrPDB 44 1e-04 4Q6R-A nrPDB 43 3e-04 3ECD-A nrPDB 43 3e-04 4OTL-A nrPDB 43 4e-04 3NDN-A nrPDB 43 4e-04 5YKR-A nrPDB 43 4e-04 4J5U-A nrPDB 43 4e-04 2CB1-A nrPDB 42 6e-04 2CH1-A nrPDB 42 8e-04 2CTZ-A nrPDB 41 0.001 4E3Q-A nrPDB 39 0.003 5VMB-A nrPDB 39 0.004 3A9Z-A nrPDB 39 0.005 3HBX-A nrPDB 39 0.006 4WXB-A nrPDB 38 0.007 3L44-A nrPDB 38 0.011 3HQT-A nrPDB 38 0.011 4EB7-A nrPDB 38 0.012 2EZ1-A nrPDB 37 0.012 1Z7D-A nrPDB 37 0.014 3NNK-A nrPDB 37 0.020 3WKR-A nrPDB 37 0.021 2FQ6-A nrPDB 36 0.027 1C7G-A nrPDB 36 0.028 4IW7-A nrPDB 36 0.040 3MC6-C nrPDB 36 0.043 5GHG-A nrPDB 35 0.097 1VJO-A nrPDB 34 0.14 5Z8A-A nrPDB 34 0.22 6GL0-A nrPDB 32 0.43 3HMU-A nrPDB 32 0.68 4RIT-B nrPDB 32 0.70 4W8I-A nrPDB 32 0.82 1QZ9-A nrPDB 31 0.88 3TQP-A nrPDB 31 0.91 1V6T-A nrPDB 31 1.0 1ORD-A nrPDB 31 1.1 4XGC-B nrPDB 31 1.1 1IUG-A nrPDB 30 1.5 2XN1-A nrPDB 30 2.0 3S81-A nrPDB 30 2.5 4XEM-A nrPDB 29 3.4 3DOD-A nrPDB 29 3.7 3ZRR-A nrPDB 29 4.2 3O55-A nrPDB 29 4.3 3QTP-A nrPDB 29 5.0 4UT1-A nrPDB 29 5.7 2HQM-A nrPDB 29 7.1 2R9G-A nrPDB 28 8.2 6GIO-D nrPDB 28 8.6 1OBH-A nrPDB 28 8.9 >5WMH-A nrPDB Length = 475 Score = 659 bits (1701), Expect = 0.0, Method: Composition-based stats. Identities = 475/475 (100%), Positives = 475/475 (100%) Query: 1 MASQSSVAVISSAAARGESFPDSKKPIGSVRFQQPLRLSFSYCKSGNMSSRICAMAKPND 60 MASQSSVAVISSAAARGESFPDSKKPIGSVRFQQPLRLSFSYCKSGNMSSRICAMAKPND Sbjct: 1 MASQSSVAVISSAAARGESFPDSKKPIGSVRFQQPLRLSFSYCKSGNMSSRICAMAKPND 60 Query: 61 AETLSSSVDMSLSPRVQSLKPSKTMVITDLAATLVQSGVPVIRLAAGEPDFDTPKVVAEA 120 AETLSSSVDMSLSPRVQSLKPSKTMVITDLAATLVQSGVPVIRLAAGEPDFDTPKVVAEA Sbjct: 61 AETLSSSVDMSLSPRVQSLKPSKTMVITDLAATLVQSGVPVIRLAAGEPDFDTPKVVAEA 120 Query: 121 GINAIREGFTRYTLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVC 180 GINAIREGFTRYTLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVC Sbjct: 121 GINAIREGFTRYTLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVC 180 Query: 181 SPGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCS 240 SPGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCS Sbjct: 181 SPGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCS 240 Query: 241 PSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLT 300 PSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLT Sbjct: 241 PSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLT 300 Query: 301 VNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGET 360 VNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGET Sbjct: 301 VNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGET 360 Query: 361 VAEMVKAYRERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSL 420 VAEMVKAYRERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSL Sbjct: 361 VAEMVKAYRERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSL 420 Query: 421 ALYFLDKFQVAMVPGDAFGDDSCIRISYATSLDVLQAAVEKIRKALEPLRATVSV 475 ALYFLDKFQVAMVPGDAFGDDSCIRISYATSLDVLQAAVEKIRKALEPLRATVSV Sbjct: 421 ALYFLDKFQVAMVPGDAFGDDSCIRISYATSLDVLQAAVEKIRKALEPLRATVSV 475 >6F77-B nrPDB Length = 400 Score = 419 bits (1078), Expect = e-118, Method: Composition-based stats. Identities = 170/400 (42%), Positives = 235/400 (58%), Gaps = 4/400 (1%) Query: 72 LSPRVQSLKPSKTMVITDLAATLVQSGVPVIRLAAGEPDFDTPKVVAEAGINAIREGFTR 131 L+ + +KPS T+ ++ A L G VI L AGEPDFDTP + +A I+AI G T+ Sbjct: 4 LADALSRVKPSATIAVSQKARELKAKGRDVIGLGAGEPDFDTPDNIKKAAIDAIDRGETK 63 Query: 132 YTLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAP 191 YT +GI ELREAI +K K EN L Y Q +V G KQ L A +A +PGDEV+IPAP Sbjct: 64 YTPVSGIPELREAIAKKFKRENNLDYTAAQTIVGTGGKQILFNAFMATLNPGDEVVIPAP 123 Query: 192 YWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPK 251 YWVSY E L TPV +PT+ NNF L +DL+ +T K++ + SPSNP+G+ Y Sbjct: 124 YWVSYPEMVALCGGTPVFVPTRQENNFKLKAEDLDRAITPKTKWFVFNSPSNPSGAAYSH 183 Query: 252 SLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASL-PDMYERTLTVNGFSKAFAM 310 L+ + ++ KHP + VL+D++YEH+ Y + + P +YERTLT+NG SKA+AM Sbjct: 184 EELKALTDVLMKHPHVWVLTDDMYEHLTYGDFRFATPVEVEPGLYERTLTMNGVSKAYAM 243 Query: 311 TGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRE 370 TGWR+GY AGP H++ A +QGQ +SGA+SIAQ A V AL + + + ++ Sbjct: 244 TGWRIGYAAGPLHLIKAMDMIQGQQTSGAASIAQWAAVEALN---GPQDFIGRNKEIFQG 300 Query: 371 RRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQV 430 RRD +V L KG+ P+GAFY++ + G A +I L+ V Sbjct: 301 RRDLVVSMLNQAKGISCPTPEGAFYVYPSCAGLIGKTAPSGKVIETDEDFVSELLETEGV 360 Query: 431 AMVPGDAFGDDSCIRISYATSLDVLQAAVEKIRKALEPLR 470 A+V G AFG RISYATS +L+ A +I++ R Sbjct: 361 AVVHGSAFGLGPNFRISYATSEALLEEACRRIQRFCAACR 400 >1J32-A nrPDB Length = 388 Score = 410 bits (1053), Expect = e-115, Method: Composition-based stats. Identities = 174/402 (43%), Positives = 249/402 (61%), Gaps = 15/402 (3%) Query: 70 MSLSPRVQSLKPSKTMVITDLAATLVQSGVPVIRLAAGEPDFDTPKVVAEAGINAIREGF 129 M L+ RV+S+ PS T++I A + G+ V +AGEPDF+TPK + EA A+ +G Sbjct: 1 MKLAARVESVSPSMTLIIDAKAKAMKAEGIDVCSFSAGEPDFNTPKHIVEAAKAALEQGK 60 Query: 130 TRYTLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIP 189 TRY AG LREAI +KL+ +NGL Y D ILV+NG KQS+ +LA+ PGDEVIIP Sbjct: 61 TRYGPAAGEPRLREAIAQKLQRDNGLCYGADNILVTNGGKQSIFNLMLAMIEPGDEVIIP 120 Query: 190 APYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVY 249 AP+WVSY E +LA+ TPV++PT + F + P+ + +T K++LL+ +PSNPTG VY Sbjct: 121 APFWVSYPEMVKLAEGTPVILPTTVETQFKVSPEQIRQAITPKTKLLVFNTPSNPTGMVY 180 Query: 250 PKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSF-ASLPDMYERTLTVNGFSKAF 308 + IA++ + L VLSDEIYE I+Y A H S A+ P+ YER++ +GF+K + Sbjct: 181 TPDEVRAIAQVAVE-AGLWVLSDEIYEKILYDDAQHLSIGAASPEAYERSVVCSGFAKTY 239 Query: 309 AMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAY 368 AMTGWR+G+LAGP +V A +K+QG +S + AQ +AA + + V EM+ A+ Sbjct: 240 AMTGWRVGFLAGPVPLVKAATKIQGHSTSNVCTFAQYGAIAAY---ENSQDCVQEMLAAF 296 Query: 369 RERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKF 428 ERR +++ +L + G++ +P GAFY+F + S S LD+ Sbjct: 297 AERRRYMLDALNAMPGLECPKPDGAFYMFPSIAKTGRS----------SLDFCSELLDQH 346 Query: 429 QVAMVPGDAFGDDSCIRISYATSLDVLQAAVEKIRKALEPLR 470 QVA VPG AFG D CIR+SYAT LD ++ +E++ K L + Sbjct: 347 QVATVPGAAFGADDCIRLSYATDLDTIKRGMERLEKFLHGIL 388 >6F35-A nrPDB Length = 410 Score = 406 bits (1043), Expect = e-113, Method: Composition-based stats. Identities = 163/398 (40%), Positives = 235/398 (59%), Gaps = 4/398 (1%) Query: 73 SPRVQSLKPSKTMVITDLAATLVQSGVPVIRLAAGEPDFDTPKVVAEAGINAIREGFTRY 132 + R+ S+ S+ + I AA + + G PVI L AGEPDFDTP+ V +A +AI G T+Y Sbjct: 15 ASRISSIGVSEILKIGARAAAMKREGKPVIILGAGEPDFDTPEHVKQAASDAIHRGETKY 74 Query: 133 TLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPY 192 T G EL++AI K + ENGL+Y D+I V+ GAKQ L A++A PGDEVIIP PY Sbjct: 75 TALDGTPELKKAIREKFQRENGLAYELDEITVATGAKQILFNAMMASLDPGDEVIIPTPY 134 Query: 193 WVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKS 252 W SY++ + + PV+I S+ F L + LE+ +T ++R ++L SPSNP+G+ Y + Sbjct: 135 WTSYSDIVHICEGKPVLIACDASSGFRLTAEKLEAAITPRTRWVLLNSPSNPSGAAYSAA 194 Query: 253 LLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASL-PDMYERTLTVNGFSKAFAMT 311 + ++ +HP + +L D++YEHI+Y + A L P + RTLTVNG SKA+AMT Sbjct: 195 DYRPLLEVLLRHPHVWLLVDDMYEHIVYDGFRFVTPAQLEPGLKNRTLTVNGVSKAYAMT 254 Query: 312 GWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRER 371 GWR+GY GP+ ++ A + +Q Q +S SSI+Q A V AL + + E ++++ R Sbjct: 255 GWRIGYAGGPRELIKAMAVVQSQATSCPSSISQAASVVALN---GPQDFLKERTESFQRR 311 Query: 372 RDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVA 431 RD +V L I G+ P+GAFY F + G I + Y L+ VA Sbjct: 312 RDLVVNGLNAIDGLDCRVPEGAFYTFSGCAGVLGKVTPSGKRIKTDTDFCAYLLEDAHVA 371 Query: 432 MVPGDAFGDDSCIRISYATSLDVLQAAVEKIRKALEPL 469 +VPG AFG RISYATS L+ A+E+I A + L Sbjct: 372 VVPGSAFGLSPFFRISYATSEAELKEALERIAAACDRL 409 >1GDE-A nrPDB Length = 389 Score = 397 bits (1021), Expect = e-111, Method: Composition-based stats. Identities = 162/404 (40%), Positives = 234/404 (57%), Gaps = 20/404 (4%) Query: 70 MSLSPRVQSLKPSKTMVITDLAATLVQSGVPVIRLAAGEPDFDTPKVVAEAGINAIREGF 129 M+LS R++ + S+ + D+AA + VI L GEPDFDTP+ + E A+ +G Sbjct: 1 MALSDRLELVSASEIRKLFDIAAGMK----DVISLGIGEPDFDTPQHIKEYAKEALDKGL 56 Query: 130 TRYTLNAGITELREAICRKLKEENGLSYAPD-QILVSNGAKQSLLQAVLAVCSPGDEVII 188 T Y N G+ ELREAI KLK++NG+ P +I+V GA Q+ L + A G+EV+I Sbjct: 57 THYGPNIGLLELREAIAEKLKKQNGIEADPKTEIMVLLGANQAFLMGLSAFLKDGEEVLI 116 Query: 189 PAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSV 248 P P +VSY LA PV +PT + F L+ +L+ +T+K+R LI+ SP NPTG+V Sbjct: 117 PTPAFVSYAPAVILAGGKPVEVPTYEEDEFRLNVDELKKYVTDKTRALIINSPCNPTGAV 176 Query: 249 YPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAF 308 K LEEIA + +H L+V+SDE+YEH IY A H S ASL M+ERT+TVNGFSK F Sbjct: 177 LTKKDLEEIADFVVEH-DLIVISDEVYEHFIYDDARHYSIASLDGMFERTITVNGFSKTF 235 Query: 309 AMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAY 368 AMTGWRLG++A P I+ K Q ++ + Q A AL + + V EM K Y Sbjct: 236 AMTGWRLGFVAAPSWIIERMVKFQMYNATCPVTFIQYAAAKALKDER-SWKAVEEMRKEY 294 Query: 369 RERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKF 428 RR + K L ++ G+ +P+GAFY+F + S + L + Sbjct: 295 DRRRKLVWKRLNEM-GLPTVKPKGAFYIFPRIRDTGLT----------SKKFSELMLKEA 343 Query: 429 QVAMVPGDAFG--DDSCIRISYATSLDVLQAAVEKIRKALEPLR 470 +VA+VPG AFG + +RISYAT+ + L+ A++++ + L+ + Sbjct: 344 RVAVVPGSAFGKAGEGYVRISYATAYEKLEEAMDRMERVLKERK 387 >1O4S-A nrPDB Length = 389 Score = 388 bits (996), Expect = e-108, Method: Composition-based stats. Identities = 148/395 (37%), Positives = 233/395 (58%), Gaps = 22/395 (5%) Query: 72 LSPRVQSLKPSKTMVITDLAATLVQSGVPVIRLAAGEPDFDTPKVVAEAGINAIREGFTR 131 +S R+ + SKTM + A L++ G VI L AGEPDF TP+ V E + +++G + Sbjct: 14 VSRRISEIPISKTMELDAKAKALIKKGEDVINLTAGEPDFPTPEPVVEEAVRFLQKGEVK 73 Query: 132 YTLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAP 191 YT GI ELRE I +++ E +PDQ++V+NGAKQ+L A +A+ PGDEVI+ +P Sbjct: 74 YTDPRGIYELREGIAKRIGERYKKDISPDQVVVTNGAKQALFNAFMALLDPGDEVIVFSP 133 Query: 192 YWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPK 251 WVSY Q LA T V+ T +S NF +++E L K++ +++ SP+NPTG VY + Sbjct: 134 VWVSYIPQIILAGGTVNVVETFMSKNFQPSLEEVEGLLVGKTKAVLINSPNNPTGVVYRR 193 Query: 252 SLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMT 311 LE + R+ K ++SDE+Y+ ++Y TS + + ++R + +NGFSK+ +MT Sbjct: 194 EFLEGLVRLAKKR-NFYIISDEVYDSLVYTDE-FTSILDVSEGFDRIVYINGFSKSHSMT 251 Query: 312 GWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRER 371 GWR+GYL + + A SK+Q +S +++AQ A + AL + + MV+ ++ER Sbjct: 252 GWRVGYLISSEKVATAVSKIQSHTTSCINTVAQYAALKALEVDNSY------MVQTFKER 305 Query: 372 RDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVA 431 ++F+V+ L + GVK EP+GAFYLF F + D L++ +VA Sbjct: 306 KNFVVERLKKM-GVKFVEPEGAFYLF-------------FKVRGDDVKFCERLLEEKKVA 351 Query: 432 MVPGDAFGDDSCIRISYATSLDVLQAAVEKIRKAL 466 +VPG AF +R+S+ATS++ L A+++I L Sbjct: 352 LVPGSAFLKPGFVRLSFATSIERLTEALDRIEDFL 386 >1GC4-A nrPDB Length = 385 Score = 386 bits (990), Expect = e-107, Method: Composition-based stats. Identities = 161/396 (40%), Positives = 230/396 (58%), Gaps = 16/396 (4%) Query: 71 SLSPRVQSLKPSKTMVITDLAATLVQSGVPVIRLAAGEPDFDTPKVVAEAGINAIREGFT 130 LS RVQ++KP + + A L + GV ++ L AGEPDFDTP+ V EA A+ +G T Sbjct: 3 GLSRRVQAMKPDAVVAVNAKALELRRQGVDLVALTAGEPDFDTPEHVKEAARRALAQGKT 62 Query: 131 RYTLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPA 190 +Y AGI ELREA+ K + ENGLS P++ +V+ G Q+L A+ PGDEVI+ + Sbjct: 63 KYAPPAGIPELREALAEKFRRENGLSVTPEETIVTVGGSQALFNLFQAILDPGDEVIVLS 122 Query: 191 PYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYP 250 PYWVSY E R A V + T F+ DP+ + +T +++ L++ SP+NPTG+VYP Sbjct: 123 PYWVSYPEMVRFAGGVVVEVETLPEEGFVPDPERVRRAITPRTKALVVNSPNNPTGAVYP 182 Query: 251 KSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAM 310 K +LE +AR+ +H ++SDEIYEH++Y + P E TLTVNG +KAFAM Sbjct: 183 KEVLEALARLAVEH-DFYLVSDEIYEHLLYEGEHFSPGRVAP---EHTLTVNGAAKAFAM 238 Query: 311 TGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRE 370 TGWR+GY GPK ++ A + + Q ++ +IAQ A + AL +A V +AYR Sbjct: 239 TGWRIGYACGPKEVIKAMASVSRQSTTSPDTIAQWATLEALTNQEASRAFVEMAREAYRR 298 Query: 371 RRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQV 430 RRD L++ L + G+K P GAFY+ +D S D A L+ V Sbjct: 299 RRDLLLEGLTAL-GLKAVRPSGAFYVLMDTSPIAP----------DEVRAAERLLE-AGV 346 Query: 431 AMVPGDAFGDDSCIRISYATSLDVLQAAVEKIRKAL 466 A+VPG F +R+SYATS + L+ A+E+ + L Sbjct: 347 AVVPGTDFAAFGHVRLSYATSEENLRKALERFARVL 382 >1XI9-A nrPDB Length = 406 Score = 359 bits (921), Expect = 1e-99, Method: Composition-based stats. Identities = 122/410 (29%), Positives = 203/410 (49%), Gaps = 28/410 (6%) Query: 70 MSLSPRVQSLKPSKTMVITDLAATLVQSGVPVIRLAAGEP---DFDTPKVVAEAGINAIR 126 + S R S++ + A L + G+ VIRL G+P DF P+ + EA AI+ Sbjct: 10 IRASKRALSVE-YAIRDVVLPARELEKKGIKVIRLNIGDPVKFDFQPPEHMKEAYCKAIK 68 Query: 127 EGFTRYTLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEV 186 EG Y + G+ ELR+AI + K +NG+ PD + V+ ++L A+ PGDE+ Sbjct: 69 EGHNYYGDSEGLPELRKAIVEREKRKNGVDITPDDVRVTAAVTEALQLIFGALLDPGDEI 128 Query: 187 IIPAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTG 246 ++P P + YT + PV T ++ D D+ K+T++++ + + +P+NPTG Sbjct: 129 LVPGPSYPPYTGLVKFYGGKPVEYRTIEEEDWQPDIDDIRKKITDRTKAIAVINPNNPTG 188 Query: 247 SVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSK 306 ++Y K LEEI I ++ + V+SDEIY+ + Y H S SL + +NG SK Sbjct: 189 ALYDKKTLEEILNIAGEYE-IPVISDEIYDLMTYEGE-HISPGSLTKDVP-VIVMNGLSK 245 Query: 307 AFAMTGWRLGYL--AGPK----HIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGET 360 + TGWRLGY+ P+ + A +L ++ ++ AQ A +A L + Sbjct: 246 VYFATGWRLGYMYFVDPENKLSEVREAIDRL-ARIRLCPNTPAQFAAIAGLT---GPMDY 301 Query: 361 VAEMVKAYRERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSL 420 + E +K +ERRD++ K L +I G+ ++PQGAFY+F G + Sbjct: 302 LKEYMKKLKERRDYIYKRLNEIPGISTTKPQGAFYIFPKIE---------VGPWKNDKEF 352 Query: 421 ALYFLDKFQVAMVPGDAFGDD--SCIRISYATSLDVLQAAVEKIRKALEP 468 L L V V G FG+ R + +++L+ A+++ K ++ Sbjct: 353 VLDVLHNAHVLFVHGSGFGEYGAGHFRAVFLPPIEILEEAMDRFEKFMKE 402 >2Z61-A nrPDB Length = 370 Score = 350 bits (899), Expect = 6e-97, Method: Composition-based stats. Identities = 129/399 (32%), Positives = 200/399 (50%), Gaps = 32/399 (8%) Query: 72 LSPRVQSLKPSKTMVITDLAATLVQSGVPVIRLAAGEPDFDTPKVVAEAGINAIREGFTR 131 LS R+ + + + M I LA L G VI L GEPDF+TPK + + GI +++EG T Sbjct: 2 LSKRLLNFESFEVMDILALAQKLESEGKKVIHLEIGEPDFNTPKPIVDEGIKSLKEGKTH 61 Query: 132 YTLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAP 191 YT + GI ELRE I K++ PD I+++ G+ L A+ ++ GDEV+I P Sbjct: 62 YTDSRGILELREKISELYKDKYKADIIPDNIIITGGSSLGLFFALSSIIDDGDEVLIQNP 121 Query: 192 YWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPK 251 + Y R A PV + LE L++K++ +I+ SPSNP G V + Sbjct: 122 CYPCYKNFIRFLGAKPVFCD--------FTVESLEEALSDKTKAIIINSPSNPLGEVIDR 173 Query: 252 SLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMT 311 + E A ++SDEIY ++Y +++ + E+T+ +NGFSK +AMT Sbjct: 174 EIYE-----FAYENIPYIISDEIYNGLVYEGKCYSAI-EFDENLEKTILINGFSKLYAMT 227 Query: 312 GWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRER 371 GWR+GY+ I+ A KLQ + A +I+Q A + A K + M+K + R Sbjct: 228 GWRIGYVISNDEIIEAILKLQQNLFISAPTISQYAALKA--FEKETEREINSMIKEFDRR 285 Query: 372 RDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVA 431 R ++K + D G +++ P GA+Y+F + D A L + VA Sbjct: 286 RRLVLKYVKDF-GWEVNNPIGAYYVFPNIG-------------EDGREFAYKLLKEKFVA 331 Query: 432 MVPGDAFGDDS--CIRISYATSLDVLQAAVEKIRKALEP 468 + PG FG IRISYA S + ++ +E+I++ L Sbjct: 332 LTPGIGFGSKGKNYIRISYANSYENIKEGLERIKEFLNK 370 >4WP0-A nrPDB Length = 472 Score = 334 bits (855), Expect = 7e-92, Method: Composition-based stats. Identities = 112/419 (26%), Positives = 189/419 (45%), Gaps = 33/419 (7%) Query: 73 SPRVQSLKPSKTMVITDLAATLVQSGVPVIRLAAGEPDFDTPKVVAEAGINAI--REGFT 130 + R+ + + + LA+ V+ L G PDF P EA +A+ Sbjct: 7 ARRLDGIDYNPWVEFVKLASE-----HDVVNLGQGFPDFPPPDFAVEAFQHAVSGDFMLN 61 Query: 131 RYTLNAGITELREAICRKLKEENGLSYAP-DQILVSNGAKQSLLQAVLAVCSPGDEVIIP 189 +YT G L + + E G P +LV+ G +L A A+ GDEVII Sbjct: 62 QYTKTFGYPPLTKILASFFGELLGQEIDPLRNVLVTVGGYGALFTAFQALVDEGDEVIII 121 Query: 190 APYWVSYTEQARLADATPVVIPTKI----------SNNFLLDPKDLESKLTEKSRLLILC 239 P++ Y +A PV + K S+N+ LDP +L K T +++ L+L Sbjct: 122 EPFFDCYEPMTMMAGGRPVFVSLKPGPIQNGELGSSSNWQLDPMELAGKFTSRTKALVLN 181 Query: 240 SPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTL 299 +P+NP G V+ + LE +A + +H ++ ++DE+Y+ ++Y H S ASLP M+ERTL Sbjct: 182 TPNNPLGKVFSREELELVASLCQQH-DVVCITDEVYQWMVYDGHQHISIASLPGMWERTL 240 Query: 300 TVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALG----LGK 355 T+ K F+ TGW++G++ GP HI+ + + +Q A + L + Sbjct: 241 TIGSAGKTFSATGWKVGWVLGPDHIMKHLRTVHQNSVFHCPTQSQAAVAESFEREQLLFR 300 Query: 356 AGGETVAEMVKAYRERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLIN 415 + +A + RD +++SL + G+K PQG+++L D S + + G ++ Sbjct: 301 QPSSYFVQFPQAMQRCRDHMIRSLQSV-GLKPIIPQGSYFLITDISDFKRKMPDLPGAVD 359 Query: 416 D--SSSLALYFLDKFQVAMVPGDAFGD-------DSCIRISYATSLDVLQAAVEKIRKA 465 + + + + +P F D IR + LQA EK+RK Sbjct: 360 EPYDRRFVKWMIKNKGLVAIPVSIFYSVPHQKHFDHYIRFCFVKDEATLQAMDEKLRKW 418 >3FVS-A nrPDB Length = 422 Score = 334 bits (855), Expect = 7e-92, Method: Composition-based stats. Identities = 112/419 (26%), Positives = 189/419 (45%), Gaps = 33/419 (7%) Query: 73 SPRVQSLKPSKTMVITDLAATLVQSGVPVIRLAAGEPDFDTPKVVAEAGINAI--REGFT 130 + R+ + + + LA+ V+ L G PDF P EA +A+ Sbjct: 7 ARRLDGIDYNPWVEFVKLASE-----HDVVNLGQGFPDFPPPDFAVEAFQHAVSGDFMLN 61 Query: 131 RYTLNAGITELREAICRKLKEENGLSYAP-DQILVSNGAKQSLLQAVLAVCSPGDEVIIP 189 +YT G L + + E G P +LV+ G +L A A+ GDEVII Sbjct: 62 QYTKTFGYPPLTKILASFFGELLGQEIDPLRNVLVTVGGYGALFTAFQALVDEGDEVIII 121 Query: 190 APYWVSYTEQARLADATPVVIPTKI----------SNNFLLDPKDLESKLTEKSRLLILC 239 P++ Y +A PV + K S+N+ LDP +L K T +++ L+L Sbjct: 122 EPFFDCYEPMTMMAGGRPVFVSLKPGPIQNGELGSSSNWQLDPMELAGKFTSRTKALVLN 181 Query: 240 SPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTL 299 +P+NP G V+ + LE +A + +H ++ ++DE+Y+ ++Y H S ASLP M+ERTL Sbjct: 182 TPNNPLGKVFSREELELVASLCQQH-DVVCITDEVYQWMVYDGHQHISIASLPGMWERTL 240 Query: 300 TVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALG----LGK 355 T+ K F+ TGW++G++ GP HI+ + + +Q A + L + Sbjct: 241 TIGSAGKTFSATGWKVGWVLGPDHIMKHLRTVHQNSVFHCPTQSQAAVAESFEREQLLFR 300 Query: 356 AGGETVAEMVKAYRERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLIN 415 + +A + RD +++SL + G+K PQG+++L D S + + G ++ Sbjct: 301 QPSSYFVQFPQAMQRCRDHMIRSLQSV-GLKPIIPQGSYFLITDISDFKRKMPDLPGAVD 359 Query: 416 D--SSSLALYFLDKFQVAMVPGDAFGD-------DSCIRISYATSLDVLQAAVEKIRKA 465 + + + + +P F D IR + LQA EK+RK Sbjct: 360 EPYDRRFVKWMIKNKGLVAIPVSIFYSVPHQKHFDHYIRFCFVKDEATLQAMDEKLRKW 418 >2X5D-A nrPDB Length = 412 Score = 328 bits (841), Expect = 3e-90, Method: Composition-based stats. Identities = 102/409 (24%), Positives = 179/409 (43%), Gaps = 17/409 (4%) Query: 64 LSSSVDMSLSPRVQSLKPSKTMVITDLAATLVQSGVPVIRLAAGEPDFDTPKVVAEAG-I 122 ++ S R+ L P + +L + G +I L+ G PD TP + E Sbjct: 2 MAESRPARRFARIDRLPPYVFNITAELKMAARRRGEDIIDLSMGNPDGPTPPHIVEKLCT 61 Query: 123 NAIREGFTRYTLNAGITELREAICRKLKEENGLSYAPD-QILVSNGAKQSLLQAVLAVCS 181 A RE Y+ + GI LR AI ++ + P+ + +V+ G+K+ L +LA Sbjct: 62 VAQREDTHGYSTSRGIPRLRRAISHWYRDRYDVQIDPESEAIVTIGSKEGLAHLMLATLD 121 Query: 182 PGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCSP 241 GD +++P P + + A +A A +P +F + + + K R++IL P Sbjct: 122 HGDTILVPNPSYPIHIYGAVIAGAQVRSVPLVPGIDFFNELERAIRESIPKPRMMILGFP 181 Query: 242 SNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTV 301 SNPT E + + K ++V+ D Y I+Y S +P + + Sbjct: 182 SNPTAQCVELDFFERVVALA-KQYDVMVVHDLAYADIVYDGWKAPSIMQVPGAKDIAVEF 240 Query: 302 NGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETV 361 SK++ M GWR+G++ G +V+A ++++ G + Q A +AAL + + V Sbjct: 241 FTLSKSYNMAGWRIGFMVGNPELVSALARIKSYHDYGTFTPLQVAAIAAL---EGDQQCV 297 Query: 362 AEMVKAYRERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLA 421 ++ + Y++RRD LVK L + G + P+ + Y++ Y S A Sbjct: 298 RDIARQYQQRRDVLVKGLREA-GWMVENPKASMYVWAKIPEPYAHLG--------SLEFA 348 Query: 422 LYFLDKFQVAMVPGDAFG--DDSCIRISYATSLDVLQAAVEKIRKALEP 468 L +V++ PG FG D +R + + D L+ AV I+ Sbjct: 349 KKLLQDAKVSVSPGIGFGDYGDDHVRFALIENRDRLRQAVRGIKAMFRA 397 >4MY5-A nrPDB Length = 393 Score = 325 bits (834), Expect = 2e-89, Method: Composition-based stats. Identities = 135/408 (33%), Positives = 218/408 (53%), Gaps = 31/408 (7%) Query: 70 MSLSPR----VQSLKPSKTMVITDLAATLVQSGVPVIRLAAGEPDFDTPKVVAEAGINAI 125 M LS R + ++ S + + V++L GEPDF TPK + EA AI Sbjct: 3 MDLSKRFNKNLNKIEVSMIRQFDQSISDIP----DVLKLTLGEPDFATPKHIKEAAKRAI 58 Query: 126 REGFTRYTLNAGITELREAICRKLKEENGLSYAPDQ-ILVSNGAKQSLLQAVLAVCSPGD 184 + YT AG+ LR+A +KE+ L+Y PD ILV+ GA ++L ++ A+ PGD Sbjct: 59 DADESHYTGMAGLLALRQAASAFVKEKYHLTYNPDNEILVTIGATEALSASLTAILEPGD 118 Query: 185 EVIIPAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLT---EKSRLLILCSP 241 +V++PAP + Y L A V I T+ SN+F+L P+ LE + E + +IL P Sbjct: 119 KVLLPAPAYPGYEPVVNLVGAEVVEIDTR-SNDFVLTPEMLEEAILKEGEALKAVILNYP 177 Query: 242 SNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTV 301 +NPTG Y + ++ +A ++ K+P + V+SDE+Y + Y +H S A + ++T+ + Sbjct: 178 TNPTGVTYSRQQIKNLAEVLKKYP-IFVISDEVYAELTYTGESHVSIAEY--LPDQTILI 234 Query: 302 NGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETV 361 +G SK+ AMTGWRLG + P + A K + + A++ Q A + AL GK Sbjct: 235 SGLSKSHAMTGWRLGLIFAPAVLTAQLIKSHQYLVTAATTSVQFAAIEALTNGKDDA--- 291 Query: 362 AEMVKAYRERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLA 421 M + Y +RRD++++ + +K KI +P GAFY+F G DS Sbjct: 292 LPMKEEYIKRRDYIIEKMEAMK-FKIIKPDGAFYIFAKIPVAQGQ---------DSFKFL 341 Query: 422 LYFLDKFQVAMVPGDAFG--DDSCIRISYATSLDVLQAAVEKIRKALE 467 F + VA +PG AFG + +RISYA S++ ++ A++++++ +E Sbjct: 342 QDFAKEKAVAFIPGVAFGKYGEGYLRISYAASMETIKEAMKRLKEFME 389 >1U08-A nrPDB Length = 386 Score = 323 bits (827), Expect = 1e-88, Method: Composition-based stats. Identities = 114/386 (29%), Positives = 192/386 (49%), Gaps = 22/386 (5%) Query: 84 TMVITDLAATLVQSGVPVIRLAAGEPDFDTPKVVAEAGINAIREGFTRYTLNAGITELRE 143 T + T ++A Q I L+ G PDFD P+ + E + + +G +Y G+ LRE Sbjct: 17 TTIFTQMSALAQQHQA--INLSQGFPDFDGPRYLQERLAHHVAQGANQYAPMTGVQALRE 74 Query: 144 AICRKLKEENGLSYAPD-QILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARL 202 AI +K + G D I V+ GA ++L A+ A+ GDEVI P + SY L Sbjct: 75 AIAQKTERLYGYQPDADSDITVTAGATEALYAAITALVRNGDEVICFDPSYDSYAPAIAL 134 Query: 203 ADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIA 262 + + + +F +D ++ + L+E++RL+IL +P NP+ +V+ ++ + + IA Sbjct: 135 SGGIVKRMALQPP-HFRVDWQEFAALLSERTRLVILNTPHNPSATVWQQADFAALWQAIA 193 Query: 263 KHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPK 322 H + V+SDE+YEHI ++ H S + P + ER + V+ F K + MTGW++GY P Sbjct: 194 GHE-IFVISDEVYEHINFSQQGHASVLAHPQLRERAVAVSSFGKTYHMTGWKVGYCVAPA 252 Query: 323 HIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLGDI 382 I A K+ ++ ++ AQ A L +A E + YR++RD LV +L + Sbjct: 253 PISAEIRKVHQYLTFSVNTPAQLALADML---RAEPEHYLALPDFYRQKRDILVNALNES 309 Query: 383 KGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVAMVPGDAFGDDS 442 + ++I +G ++L +D+SA D + + VA +P F D Sbjct: 310 R-LEILPCEGTYFLLVDYSAVS---------TLDDVEFCQWLTQEHGVAAIPLSVFCADP 359 Query: 443 C----IRISYATSLDVLQAAVEKIRK 464 IR+ +A L AA E++R+ Sbjct: 360 FPHKLIRLCFAKKESTLLAAAERLRQ 385 >2ZJG-A nrPDB Length = 410 Score = 322 bits (824), Expect = 2e-88, Method: Composition-based stats. Identities = 117/415 (28%), Positives = 188/415 (45%), Gaps = 29/415 (6%) Query: 73 SPRVQSLKPSKTMVITDLAATLVQSGVPVIRLAAGEPDFDTPKVVAEAG-INAIREGFTR 131 + R++ L + + T LAA V+ L G PD P V E A + + Sbjct: 2 AKRIEGLDSNVWVEFTKLAA-----DPSVVNLGQGFPDISPPSYVKEELSKAAFIDNMNQ 56 Query: 132 YTLNAGITELREAICRKLKEENGLSYAP-DQILVSNGAKQSLLQAVLAVCSPGDEVIIPA 190 YT G L +A+ + P ++ILV+ GA SL ++ + PGDEVII Sbjct: 57 YTRGFGHPALVKALSCLYGKIYQRQIDPNEEILVAVGAYGSLFNSIQGLVDPGDEVIIMV 116 Query: 191 PYWVSYTEQARLADATPVVIPTKI---------SNNFLLDPKDLESKLTEKSRLLILCSP 241 P++ Y R+A A PV IP + S+++ DP++LESK + K++ +IL +P Sbjct: 117 PFYDCYEPMVRMAGAVPVFIPLRSKPTDGMKWTSSDWTFDPRELESKFSSKTKAIILNTP 176 Query: 242 SNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTV 301 NP G VY + L+ IA + KH L +SDE+YE ++Y TH A+LP M+ERT+T+ Sbjct: 177 HNPLGKVYTRQELQVIADLCVKH-DTLCISDEVYEWLVYTGHTHVKIATLPGMWERTITI 235 Query: 302 NGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLG----KAG 357 K F++TGW+LG+ GP H++ +Q ++ Q A A + Sbjct: 236 GSAGKTFSVTGWKLGWSIGPAHLIKHLQTVQQNSFYTCATPLQAALAEAFWIDIKRMDDP 295 Query: 358 GETVAEMVKAYRERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDS 417 + K +RD +V+ L + G+K P G +++ D S+ ++ Sbjct: 296 ECYFNSLPKELEVKRDRMVRLLNSV-GLKPIVPDGGYFIIADVSSLGADLSDMNSDEPYD 354 Query: 418 SSLALYFLDKFQVAMVPGDAFGD-------DSCIRISYATSLDVLQAAVEKIRKA 465 + ++ +P AF D + +R + L AA E R Sbjct: 355 YKFVKWMTKHKKLTAIPVSAFCDSKSKPHFEKLVRFCFIKKDSTLDAAEEIFRAW 409 >1YIY-A nrPDB Length = 429 Score = 312 bits (799), Expect = 2e-85, Method: Composition-based stats. Identities = 106/428 (24%), Positives = 186/428 (43%), Gaps = 33/428 (7%) Query: 62 ETLSSSVDMSLSPRVQSLKPSKTMVITDLAATLVQSGVPVIRLAAGEPDFDTPKVVAEAG 121 ET+ + D L R Q S + LAA + L G PD+ PK A Sbjct: 7 ETMHNKFD--LPKRYQGSTKSVWVEYIQLAAQYKP-----LNLGQGFPDYHAPKYALNAL 59 Query: 122 INAIREG---FTRYTLNAGITELREAICRKLKEENGLSYAPD-QILVSNGAKQSLLQAVL 177 A +YT G L +A+ + + + P ++LV+ GA ++L + Sbjct: 60 AAAANSPDPLANQYTRGFGHPRLVQALSKLYSQLVDRTINPMTEVLVTVGAYEALYATIQ 119 Query: 178 AVCSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKI--------SNNFLLDPKDLESKL 229 GDEVII P++ Y + A P IP K S +++LD +LE+ Sbjct: 120 GHVDEGDEVIIIEPFFDCYEPMVKAAGGIPRFIPLKPNKTGGTISSADWVLDNNELEALF 179 Query: 230 TEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFA 289 EK++++I+ +P NP G V ++ LE +A + K +L +SDE+YEH+++ P H Sbjct: 180 NEKTKMIIINTPHNPLGKVMDRAELEVVANLCKKW-NVLCVSDEVYEHMVFEPFEHIRIC 238 Query: 290 SLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVA 349 +LP M+ERT+T+ K F++TGW++G+ GP+ ++ + ++ Q+A Sbjct: 239 TLPGMWERTITIGSAGKTFSLTGWKIGWAYGPEALLKNLQMVHQNCVYTCATPIQEAIAV 298 Query: 350 A----LGLGKAGGETVAEMVKAYRERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYG 405 L K+ + +RD++ L ++ G+ + PQG +++ D+S+ Sbjct: 299 GFETELKRLKSPECYFNSISGELMAKRDYMASFLAEV-GMNPTVPQGGYFMVADWSSLDS 357 Query: 406 S-EAEGFGLINDSSSLALYFLDKFQVAMVPGDAFG-------DDSCIRISYATSLDVLQA 457 + + + +P AF + +R + + LQ Sbjct: 358 KVDLTQETDARKDYRFTKWMTKSVGLQGIPPSAFYSEPNKHLGEDFVRYCFFKKDENLQK 417 Query: 458 AVEKIRKA 465 A E +RK Sbjct: 418 AAEILRKW 425 >2O0R-A nrPDB Length = 411 Score = 308 bits (789), Expect = 3e-84, Method: Composition-based stats. Identities = 118/403 (29%), Positives = 188/403 (46%), Gaps = 31/403 (7%) Query: 76 VQSLKPSKTMVITDLAATLVQSGVPVIRLAAGEPDFDTPKVVAEAGINAIREGFTRYTLN 135 V L+P T V +++A + G + L G PD D P + +A +AI G +Y Sbjct: 4 VSRLRPYATTVFAEMSALATRIGA--VNLGQGFPDEDGPPKMLQAAQDAIAGGVNQYPPG 61 Query: 136 AGITELREAICRKLKEENGLSYAPD-QILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWV 194 G LR AI + + G+ Y P+ ++LV+ GA +++ AVL + PG EV++ P++ Sbjct: 62 PGSAPLRRAIAAQRRRHFGVDYDPETEVLVTVGATEAIAAAVLGLVEPGSEVLLIEPFYD 121 Query: 195 SYTEQARLADATPVVIPTKIS-NNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSL 253 SY+ +A A V +P F LD L +T ++R LI+ SP NPTG+V + Sbjct: 122 SYSPVVAMAGAHRVTVPLVPDGRGFALDADALRRAVTPRTRALIINSPHNPTGAVLSATE 181 Query: 254 LEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGW 313 L IA L+V++DE+YEH+++ A H A M ERT+T++ +K F TGW Sbjct: 182 LAA-IAEIAVAANLVVITDEVYEHLVFDHARHLPLAGFDGMAERTITISSAAKMFNCTGW 240 Query: 314 RLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRD 373 ++G+ GP ++A + +S + Q A AL A VA + + R RRD Sbjct: 241 KIGWACGPAELIAGVRAAKQYLSYVGGAPFQPAVALALDTEDA---WVAALRNSLRARRD 297 Query: 374 FLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVAMV 433 L L +I G + + G ++L D +DS+ +K VA + Sbjct: 298 RLAAGLTEI-GFAVHDSYGTYFLCADPRPLG---------YDDSTEFCAALPEKVGVAAI 347 Query: 434 PGDAFGDD-------------SCIRISYATSLDVLQAAVEKIR 463 P AF D +R ++ D L A+ ++ Sbjct: 348 PMSAFCDPAAGQASQQADVWNHLVRFTFCKRDDTLDEAIRRLS 390 >5YHV-A nrPDB Length = 394 Score = 308 bits (788), Expect = 4e-84, Method: Composition-based stats. Identities = 108/392 (27%), Positives = 171/392 (43%), Gaps = 19/392 (4%) Query: 78 SLKPSKTMVITDLAATLVQSGVPVIRLAAGEPDFDTPKVVAEAGINAIREGFTRYTLNAG 137 + P M + AA ++ ++ L+AG+P P+ V A A+ Y++ G Sbjct: 16 GVPPFYVMDVWLAAAERQRTHGDLVNLSAGQPSAGAPEPVRAAAAAALHLNQLGYSVALG 75 Query: 138 ITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYT 197 I ELR+AI + +G++ PD ++++ G+ L A LA GD V + +P + Y Sbjct: 76 IPELRDAIAADYQRRHGITVEPDAVVITTGSSGGFLLAFLACFDAGDRVAMASPGYPCYR 135 Query: 198 EQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEI 257 V IP F + L + R +++ SP+NPTG+V P L I Sbjct: 136 NILSALGCEVVEIPCGPQTRFQPTAQMLAE-IDPPLRGVVVASPANPTGTVIPPEELAAI 194 Query: 258 ARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGY 317 A + ++SDE+Y ++Y A TS A + VN FSK +AMTGWRLG+ Sbjct: 195 ASWCDA-SDVRLISDEVYHGLVYQGAPQTSCA--WQTSRNAVVVNSFSKYYAMTGWRLGW 251 Query: 318 LAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVK 377 L P + A L G + ++Q A V+A + +Y R L+ Sbjct: 252 LLVPTVLRRAVDCLTGNFTICPPVLSQIAAVSAFT--PEATAEADGNLASYAINRSLLLD 309 Query: 378 SLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVAMVPGDA 437 L I +++ GAFY++ D S +DS + L VA+ PG Sbjct: 310 GLRRIGIDRLAPTDGAFYVYADVS----------DFTSDSLAFCSKLLADTGVAIAPGID 359 Query: 438 F---GDDSCIRISYATSLDVLQAAVEKIRKAL 466 F S +RIS+A ++ A+ +I L Sbjct: 360 FDTARGGSFVRISFAGPSGDIEEALRRIGSWL 391 >3H14-A nrPDB Length = 391 Score = 303 bits (776), Expect = 1e-82, Method: Composition-based stats. Identities = 98/395 (24%), Positives = 173/395 (43%), Gaps = 25/395 (6%) Query: 77 QSLKPSKTMVITDLAATLVQSGVPVIRLAAGEPDFDTPKVVAEAGINAIREGFTRYTLNA 136 ++ P M + + A ++G +I + G+P P+ EA ++ YT+ Sbjct: 9 SAVDPFIVMDVMEAARRAEEAGRRIIHMEVGQPGTGAPRGAVEALAKSLETDALGYTVAL 68 Query: 137 GITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSY 196 G+ LR+ I R E G+ P +++++ G+ L A A+ GD V I AP + SY Sbjct: 69 GLPALRQRIARLYGEWYGVDLDPGRVVITPGSSGGFLLAFTALFDSGDRVGIGAPGYPSY 128 Query: 197 TEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEE 256 + R PV +PT N P D L++ SP+NPTG++ + + Sbjct: 129 RQILRALGLVPVDLPTAPENRLQPVPADFAGLDLAG---LMVASPANPTGTMLDHAAMGA 185 Query: 257 IARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLG 316 + A+ +SDEIY I Y T+ ++ + +N FSK F+MTGWR+G Sbjct: 186 LIE-AAQAQGASFISDEIYHGIEYEAKAVTAL----ELTDECYVINSFSKYFSMTGWRVG 240 Query: 317 YLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLV 376 ++ P+ V ++ + A +Q A + + Y+ R ++ Sbjct: 241 WMVVPEDQVRVVERIAQNMFICAPHASQVAA----LAALDCDAELQANLDVYKANRKLML 296 Query: 377 KSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVAMVPGD 436 + L +I+ P GAFY++ D S L +DS + A L+K VA+ PG Sbjct: 297 ERLPKAGFTRIAPPDGAFYVYADVS----------DLTDDSRAFAAEILEKAGVAVTPGL 346 Query: 437 AFGDD---SCIRISYATSLDVLQAAVEKIRKALEP 468 F + +R SYA + ++ ++++ ++ Sbjct: 347 DFDPERGAGTLRFSYARATADIEEGLDRLEAFMQA 381 >3DYD-A nrPDB Length = 427 Score = 300 bits (767), Expect = 1e-81, Method: Composition-based stats. Identities = 89/398 (22%), Positives = 163/398 (40%), Gaps = 24/398 (6%) Query: 82 SKTMVITDLAATLVQSGVPVIRLAAGEP----DFDTPKVVAEAGINAIREG-FTRYTLNA 136 + I D +I L+ G+P + T V +A +A+ G + Y + Sbjct: 37 NPIRAIVDNMKVKPNPNKTMISLSIGDPTVFGNLPTDPEVTQAMKDALDSGKYNGYAPSI 96 Query: 137 GITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSY 196 G RE I +++++G Q++ + + +PG +++P P + Y Sbjct: 97 GFLSSREEIASYYHCPE-APLEAKDVILTSGCSQAIDLCLAVLANPGQNILVPRPGFSLY 155 Query: 197 TEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEE 256 A + ++ +D K LE + EK+ LI+ +PSNP GSV+ K L++ Sbjct: 156 KTLAESMGIEVKLYNLLPEKSWEIDLKQLEYLIDEKTACLIVNNPSNPCGSVFSKRHLQK 215 Query: 257 IARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLG 316 I + A+ + +L+DEIY ++++ + A+L L+ G +K + + GWRLG Sbjct: 216 ILAVAARQ-CVPILADEIYGDMVFSDCKYEPLATLSTDVP-ILSCGGLAKRWLVPGWRLG 273 Query: 317 YLAGP-------KHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYR 369 ++ I KL ++ G +I Q A + L + GE + + Sbjct: 274 WILIHDRRDIFGNEIRDGLVKLSQRI-LGPCTIVQGALKSIL--CRTPGEFYHNTLSFLK 330 Query: 370 ERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQ 429 D +L I G++ P GA YL + G E E F + + + Sbjct: 331 SNADLCYGALAAIPGLRPVRPSGAMYLMV------GIEMEHFPEFENDVEFTERLVAEQS 384 Query: 430 VAMVPGDAFGDDSCIRISYATSLDVLQAAVEKIRKALE 467 V +P F + IR+ ++ A +I++ E Sbjct: 385 VHCLPATCFEYPNFIRVVITVPEVMMLEACSRIQEFCE 422 >3PDX-A nrPDB Length = 402 Score = 299 bits (766), Expect = 2e-81, Method: Composition-based stats. Identities = 88/398 (22%), Positives = 163/398 (40%), Gaps = 24/398 (6%) Query: 82 SKTMVITDLAATLVQSGVPVIRLAAGEP----DFDTPKVVAEAGINAIREG-FTRYTLNA 136 + I D VI L+ G+P + T V +A +A+ G + Y + Sbjct: 14 NPIRAIVDNMKVKPNPNKTVISLSIGDPTVFGNLPTDPEVTQAMKDALDSGKYNGYAPSI 73 Query: 137 GITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSY 196 G RE + +++++G Q++ + + +PG ++IP P + Y Sbjct: 74 GYLSSREEVASYYHCPE-APLEAKDVILTSGCSQAIELCLAVLANPGQNILIPRPGFSLY 132 Query: 197 TEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEE 256 A + ++ +D K LES + EK+ L++ +PSNP GSV+ K L++ Sbjct: 133 RTLAESMGIEVKLYNLLPEKSWEIDLKQLESLIDEKTACLVVNNPSNPCGSVFSKRHLQK 192 Query: 257 IARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLG 316 I +A+ + +L+DEIY ++++ + A+L L+ G +K + + GWRLG Sbjct: 193 IL-AVAERQCVPILADEIYGDMVFSDCKYEPMATLSTNVP-ILSCGGLAKRWLVPGWRLG 250 Query: 317 YLAGP-------KHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYR 369 ++ I KL ++ G +I Q A + L + E + + + Sbjct: 251 WILIHDRRDIFGNEIRDGLVKLSQRI-LGPCTIVQGALKSIL--QRTPQEFYQDTLSFLK 307 Query: 370 ERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQ 429 D +L I G++ P GA YL + G E E F + + + Sbjct: 308 SNADLCYGALSAIPGLQPVRPSGAMYLMV------GIEMEHFPEFENDVEFTERLIAEQS 361 Query: 430 VAMVPGDAFGDDSCIRISYATSLDVLQAAVEKIRKALE 467 V +P F + R+ ++ A +I++ E Sbjct: 362 VHCLPATCFEYPNFFRVVITVPEVMMLEACSRIQEFCE 399 >1V2E-A nrPDB Length = 381 Score = 293 bits (749), Expect = 1e-79, Method: Composition-based stats. Identities = 110/406 (27%), Positives = 187/406 (46%), Gaps = 39/406 (9%) Query: 70 MSLSPRVQSLKPSKTMVITDLAATLVQSGVPVIRLAAGEPDFDTPKVVAEAGINAIREGF 129 M L PR ++ K S ++ LA L + L G P P + EA A+ Sbjct: 1 MRLHPRTEAAKESIFPRMSGLAQRL-----GAVNLGQGFPSNPPPPFLLEAVRRALGRQ- 54 Query: 130 TRYTLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIP 189 +Y AG+ LREA+ + P+ ++V++GA ++L + ++ PGDEV++ Sbjct: 55 DQYAPPAGLPALREALAEEFA------VEPESVVVTSGATEALYVLLQSLVGPGDEVVVL 108 Query: 190 APYWVSYTEQARLADATPVVIPTKI-SNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSV 248 P++ Y A LA A ++ + F LD LE LT ++R L+L +P NPTG V Sbjct: 109 EPFFDVYLPDAFLAGAKARLVRLDLTPEGFRLDLSALEKALTPRTRALLLNTPMNPTGLV 168 Query: 249 YPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAF 308 + + LE IAR+ H L ++SDE+Y+ + Y P ERT TV K Sbjct: 169 FGERELEAIARLARAH-DLFLISDEVYDELYYGERPRRLREFAP---ERTFTVGSAGKRL 224 Query: 309 AMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAY 368 TG+R+G++ GPK + + ++ S A + Q AL L + G + + Y Sbjct: 225 EATGYRVGWIVGPKEFMPRLAGMRQWTSFSAPTPLQAGVAEALKLARREG-FYEALREGY 283 Query: 369 RERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKF 428 R RRD L L + G+++ P+G ++L + + A +++ Sbjct: 284 RRRRDLLAGGLRAM-GLRVYVPEGTYFLMAELPGWD----------------AFRLVEEA 326 Query: 429 QVAMVPGDAFGDD----SCIRISYATSLDVLQAAVEKIRKALEPLR 470 +VA++P AF + R ++ + + L A+E++ + + R Sbjct: 327 RVALIPASAFYLEDPPKDLFRFAFCKTEEELHLALERLGRVVNSPR 372 >4CVQ-A nrPDB Length = 431 Score = 291 bits (744), Expect = 6e-79, Method: Composition-based stats. Identities = 113/393 (28%), Positives = 191/393 (48%), Gaps = 23/393 (5%) Query: 87 ITDLAATLVQSGVPVIRLAAGEP---DFDTPKVVAEAGINAIREGFTRYTLNAGITELRE 143 + A L + G V++L G P FD P + I + Y + G+ R+ Sbjct: 47 VLKEAKRLEEEGNKVLKLNIGNPAPFGFDAPDEILVDVIRNL-PTAQGYCDSKGLYSARK 105 Query: 144 AICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLA 203 AI + + + I + NG + ++QA+ A+ + GDE+++PAP + +T L+ Sbjct: 106 AIMQHYQARGMRDVTVEDIYIGNGVSELIVQAMQALLNSGDEMLVPAPDYPLWTAAVSLS 165 Query: 204 DATPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAK 263 V S+++ D D+ +K+T ++R +++ +P+NPTG+VY K LL EI I + Sbjct: 166 SGKAVHYLCDESSDWFPDLDDIRAKITPRTRGIVIINPNNPTGAVYSKELLMEIVEIARQ 225 Query: 264 HPRLLVLSDEIYEHIIYAPATHTSFASL-PDMYERTLTVNGFSKAFAMTGWRLGYLA--G 320 H L++ +DEIY+ I+Y A H S A L PD+ T+T NG SK + + G+R G++ G Sbjct: 226 H-NLIIFADEIYDKILYDDAEHHSIAPLAPDLL--TITFNGLSKTYRVAGFRQGWMVLNG 282 Query: 321 PKHIVAAC---SKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVK 377 PK ++ + A+ AQ A ALG ++ E + + Y E+R+ + Sbjct: 283 PKKHAKGYIEGLEMLASMRLCANVPAQHAIQTALGGYQSISEFITPGGRLY-EQRNRAWE 341 Query: 378 SLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVAMVPGDA 437 + DI GV +P+GA Y+F A I+D + L FL + +V +V G A Sbjct: 342 LINDIPGVSCVKPRGALYMFPKIDAKRF-------NIHDDQKMVLDFLLQEKVLLVQGTA 394 Query: 438 FG--DDSCIRISYATSLDVLQAAVEKIRKALEP 468 F RI +D ++ ++ K + L Sbjct: 395 FNWPWPDHFRIVTLPRVDDIELSLSKFARFLSG 427 >4DQ6-A nrPDB Length = 391 Score = 288 bits (738), Expect = 3e-78, Method: Composition-based stats. Identities = 81/392 (20%), Positives = 173/392 (44%), Gaps = 33/392 (8%) Query: 86 VITDLAATLVQSGVPVIRLAAGEPDFDTPKVVAEAGINAIREGFTRYTLNAGITELREAI 145 +++ ++ + + DF + ++ N + + YT E+I Sbjct: 21 KWSEMEKKYGT--NDLLPMWVADMDFKAAPCIIDSLKNRLEQEIYGYTTRP--DSYNESI 76 Query: 146 CRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADA 205 L + + ++ S G ++ + + D+++I P + + + + Sbjct: 77 VNWLYRRHNWKIKSEWLIYSPGVIPAISLLINELTKANDKIMIQEPVYSPFNSVVKNNNR 136 Query: 206 TPVVIPTK--ISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAK 263 ++ P + + N+++D +D+E+K+ + +L ILC+P NP G V+ K L+++ I K Sbjct: 137 ELIISPLQKLENGNYIMDYEDIENKIKD-VKLFILCNPHNPVGRVWTKDELKKLGDICLK 195 Query: 264 HPRLLVLSDEIYEHIIYAPATHTSFASLPDMYE-RTLTVNGFSKAFAMTGWRLGYLAGPK 322 H + ++SDEI+ II H AS+ +E T+T +K F + G + Y+ P Sbjct: 196 H-NVKIISDEIHSDIILKKHKHIPMASISKEFEKNTITCMAPTKTFNIAGLQSSYVVLPD 254 Query: 323 H-----IVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVK 377 + A +++ + ++ S +A +A G + ++ DF +K Sbjct: 255 EKDYKLLDDAFTRIDIKRNNCFSLVATEAS------YNNGESWLESFLEYLESNIDFAIK 308 Query: 378 SLGD-IKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVAMVPGD 436 + + + +K+ +P+G + L++DFSA S L + K +VA+ G+ Sbjct: 309 YINENMPKLKVRKPEGTYLLWVDFSALGLS----------DEELESILVQKGKVALNQGN 358 Query: 437 AF--GDDSCIRISYATSLDVLQAAVEKIRKAL 466 +F G RI+ A +L+ A+ +I+ A+ Sbjct: 359 SFGIGGSGYQRINLACPRSMLEEALIRIKNAI 390 >3L8A-A nrPDB Length = 421 Score = 285 bits (729), Expect = 3e-77, Method: Composition-based stats. Identities = 85/376 (22%), Positives = 171/376 (45%), Gaps = 19/376 (5%) Query: 96 QSGVPVIRLAAGEPDFDTPKVVAEAGINAIREGFTRYTLNAGITELREAICRKLKEENGL 155 ++ ++++ + DF + EA IN RE Y N +L +A+ ++E+ Sbjct: 58 ENNPELLQMWVADMDFLPVPEIKEAIINYGREHIFGY--NYFNDDLYQAVIDWERKEHDY 115 Query: 156 SYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKIS 215 + + IL +G ++ A+ A GD V+I +P + + RL D V +I Sbjct: 116 AVVKEDILFIDGVVPAISIALQAFSEKGDAVLINSPVYYPFARTIRLNDHRLVENSLQII 175 Query: 216 NN-FLLDPKDLESKLTEK-SRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDE 273 N F +D + LE + + ++ +LCSP NP G V+ L +IA + KH ++++SDE Sbjct: 176 NGRFEIDFEQLEKDIIDNNVKIYLLCSPHNPGGRVWDNDDLIKIAELCKKH-GVILVSDE 234 Query: 274 IYEHIIYAPATHTSFASLPDMY-ERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQ 332 I++ + TH S +L Y + T+ ++ +K F + G + + + + + Sbjct: 235 IHQDLALFGNTHHSLNTLDASYKDFTIILSSATKTFNIAGTKNSFAIIQNESLRRKFQYR 294 Query: 333 GQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLGDIKGVKISEPQG 392 Q+++ + +A + G + E+ ++K L +K+ EP+G Sbjct: 295 -QLANNQHEVPTVGMIATQAAFQYGKPWLEELKTVIEGNIKLVIKELEAKTKIKVMEPEG 353 Query: 393 AFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVAMVPGDAFGDDS--CIRISYAT 450 + +++DFSAY ++ + L+ ++ +V + G FG + R++ AT Sbjct: 354 TYLVWLDFSAYAIAQPQ----------LSEKLQNEAKVVLNDGAHFGKEGKYFARLNVAT 403 Query: 451 SLDVLQAAVEKIRKAL 466 + +Q A+ +I Sbjct: 404 PKNTVQEALSRIISVF 419 >5Z0Q-C nrPDB Length = 389 Score = 282 bits (722), Expect = 2e-76, Method: Composition-based stats. Identities = 86/411 (20%), Positives = 169/411 (41%), Gaps = 34/411 (8%) Query: 60 DAETLSSSVDMSLSPRVQSLKPSKTMVITDLAATLVQSGVPVIRLAAGEPDFDTPKVVAE 119 +++ + + D + R K D ++ L + DF + + Sbjct: 5 ESDIMPFNFDQRIDRR--HSDSLKWKKYAD---------RDILPLWIADTDFRAADCIID 53 Query: 120 AGINAIREGFTRYTLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAV 179 A +++G Y + + L E +++ G P+ ++ G + AV A Sbjct: 54 ALQQRVQQGVFGYGVTS--EALAEVAIERMESRFGWKIQPEWLVFLPGVVTGINIAVRAF 111 Query: 180 CSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKIS-NNFLLDPKDLESKLTEKSRLLIL 238 + P + + +LA + ++ ++LD E +++ +LL+L Sbjct: 112 TEAHQSTVSATPIYPPFFLAPKLAGRQHLSAALRLEQQRWVLDLDSHEDRMSGNEKLLLL 171 Query: 239 CSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPA-THTSFASL-PDMYE 296 C+P NP G+VY + LE R +H LLV SDEI+ ++ P H FASL D + Sbjct: 172 CNPHNPGGTVYRRKELEAQLRFAQRH-DLLVCSDEIHCDLVLEPGVQHIPFASLSDDAAQ 230 Query: 297 RTLTVNGFSKAFAMTGWRLGYLAGP-KHIVAACSKLQGQVSSGASSIAQKAGVAALGLGK 355 R++T+ SK+F + G P + A ++++ + +A A AA + Sbjct: 231 RSITLMSPSKSFNIAGLGASLAVIPNPELRARFNRMRKGMVPDVDVLAYVAASAAW---R 287 Query: 356 AGGETVAEMVKAYRERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLIN 415 G + + R RD L + + + G+ + P+ +F +ID S ++ F Sbjct: 288 EGQPWLDAQLDYLRANRDMLAQHVNRLPGLSMVTPEASFLGWIDASGLGVADPALF---- 343 Query: 416 DSSSLALYFLDKFQVAMVPGDAFGDDSCIRISYATSLDVLQAAVEKIRKAL 466 +K + G FG+D +R ++ +L+ A++++ +AL Sbjct: 344 ---------FEKHGLGFSSGRDFGNDRFVRFNFGCPRQLLEEALQRMTRAL 385 >3T32-A nrPDB Length = 383 Score = 280 bits (716), Expect = 9e-76, Method: Composition-based stats. Identities = 89/373 (23%), Positives = 162/373 (43%), Gaps = 19/373 (5%) Query: 99 VPVIRLAAGEPDFDTPKVVAEAGINAIREGFTRYTLNAGITELREAICRKLKEENGLSYA 158 +I + DF+ P+ + A I YTL + + IC K++ Sbjct: 24 EELIHAWIADMDFEVPQPIQTALKKRIEHPIFGYTLPP--ENIGDIICNWTKKQYNWDIQ 81 Query: 159 PDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNN- 217 + I+ S G +L ++ A + V++ P + + E + V P + N+ Sbjct: 82 KEWIVFSAGIVPALSTSIQAFTKENESVLVQPPIYPPFFEMVTTNNRQLCVSPLQKQNDT 141 Query: 218 FLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEH 277 + +D + LE + + +L++LCSP NP G V+ K L ++ + K+ ++V++DEI+ Sbjct: 142 YAIDFEHLEKQFQQGVKLMLLCSPHNPIGRVWKKEELTKLGSLCTKY-NVIVVADEIHSD 200 Query: 278 IIYAPATHTSFASLPDM-YERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVS 336 IIYA THT FASL + RT+T SK F + G + + P + Q Sbjct: 201 IIYADHTHTPFASLSEELAARTITCMAPSKTFNIAGLQASIIIIPNEKLRQAFT-SIQYR 259 Query: 337 SGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLGD-IKGVKISEPQGAFY 395 G + A A + + E+ + F + + D I + + +P+G+F Sbjct: 260 QGFHGLNIFAYTAMQSAYTECNDWLNEIRFYIEDNAKFACEYIKDHIPTLSVMKPEGSFL 319 Query: 396 LFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVAMVPGDAF--GDDSCIRISYATSLD 453 L+ID SA S+ E L+ +K ++ + PG+ + G + I I+ Sbjct: 320 LWIDCSALNLSQDERTKLLE----------EKGKIIVEPGEKYGLGGEEHIGINIGCPRS 369 Query: 454 VLQAAVEKIRKAL 466 VL+ + ++R Sbjct: 370 VLEEILNRLRHTF 382 >2O1B-A nrPDB Length = 404 Score = 279 bits (714), Expect = 1e-75, Method: Composition-based stats. Identities = 93/405 (22%), Positives = 175/405 (43%), Gaps = 30/405 (7%) Query: 71 SLSPRVQSLKPSKTMVITD------LAATLVQSGVPVIRLAAGEPDFDTPKVVAEAGINA 124 L PR + +K I D + + +P+I +A G PD TP+ + + A Sbjct: 13 GLVPRGSHMISNKLANIPDSYFGKTMGRKIEHGPLPLINMAVGIPDGPTPQGIIDHFQKA 72 Query: 125 IREGFTR-YTLNAGITELREAICRKLKEENGLSYAP-DQILVSNGAKQSLLQAVLAVCSP 182 + + Y G ++AI + + ++ D++ + G K L+ V +P Sbjct: 73 LTIPENQKYGAFHGKEAFKQAIVDFYQRQYNVTLDKEDEVCILYGTKNGLVAVPTCVINP 132 Query: 183 GDEVIIPAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCSPS 242 GD V++P P + Y LAD PV + + ++L D ++S++ +K++L+ L P+ Sbjct: 133 GDYVLLPDPGYTDYLAGVLLADGKPVPLNLEPP-HYLPDWSKVDSQIIDKTKLIYLTYPN 191 Query: 243 NPTGSVYPKSLLEE-IARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTV 301 NPTGS K + +E IA+ K ++ D Y + A + S + + + + + Sbjct: 192 NPTGSTATKEVFDEAIAKF--KGTDTKIVHDFAYGAFGFD-AKNPSILASENGKDVAIEI 248 Query: 302 NGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETV 361 SK + M+G+R+G+ G K ++ A K Q ++G Q A + AL + + Sbjct: 249 YSLSKGYNMSGFRVGFAVGNKDMIQALKKYQTHTNAGMFGALQDAAIYALN---HYDDFL 305 Query: 362 AEMVKAYRERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLA 421 E ++ RRD L + +G Y++++ Y DS Sbjct: 306 EEQSNVFKTRRDRFEAMLAKAD-LPFVHAKGGIYVWLETPPGY-----------DSEQFE 353 Query: 422 LYFLDKFQVAMVPGDAFGDDS--CIRISYATSLDVLQAAVEKIRK 464 + + + + + PG FG++ +RIS A L A ++ + Sbjct: 354 QFLVQEKSILVAPGKPFGENGNRYVRISLALDDQKLDEAAIRLTE 398 >3B1C-A nrPDB Length = 392 Score = 279 bits (714), Expect = 2e-75, Method: Composition-based stats. Identities = 82/373 (21%), Positives = 167/373 (44%), Gaps = 20/373 (5%) Query: 96 QSGVPVIRLAAGEPDFDTPKVVAEAGINAIREGFTRYTLNAGITELREAICRKLKEENGL 155 ++ ++ + DF+ V +A + + YT EL +A+ K E+ Sbjct: 28 ETDPQLLPAWIADMDFEVMPEVKQAIHDYAEQLVYGYT--YASDELLQAVLDWEKSEHQY 85 Query: 156 SYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKIS 215 S+ + I+ G ++ A+ A G+ V+I +P + + RL + V K Sbjct: 86 SFDKEDIVFVEGVVPAISIAIQAFTKEGEAVLINSPVYPPFARSVRLNNRKLVSNSLKEE 145 Query: 216 NN-FLLDPKDLESKLTEK-SRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDE 273 N F +D + LE+ + E +L +LC+P NP G V+ + +LE+I + KH ++++SDE Sbjct: 146 NGLFQIDFEQLENDIVENDVKLYLLCNPHNPGGRVWEREVLEQIGHLCQKH-HVILVSDE 204 Query: 274 IYEHIIYAPATHTSFASL-PDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQ 332 I++ + H SF ++ PD + L ++ +K F + G + Y + A K Sbjct: 205 IHQDLTLFGHEHVSFNTVSPDFKDFALVLSSATKTFNIAGTKNSYAIIENPTLCAQFK-H 263 Query: 333 GQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLG-DIKGVKISEPQ 391 Q+ + ++ +A + G + + E F V+ + +K+ +PQ Sbjct: 264 QQLVNNHHEVSSLGYIATETAYRYGKPWLVALKAVLEENIQFAVEYFAQEAPRLKVMKPQ 323 Query: 392 GAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVAMVPGDAFGDDS--CIRISYA 449 G + +++DFS Y ++ F L++D + +V + G +G + R++ A Sbjct: 324 GTYLIWLDFSDYGLTDDALFTLLHD----------QAKVILNRGSDYGSEGELHARLNIA 373 Query: 450 TSLDVLQAAVEKI 462 +++ ++I Sbjct: 374 APKSLVEEICKRI 386 >3B46-A nrPDB Length = 447 Score = 278 bits (711), Expect = 3e-75, Method: Composition-based stats. Identities = 79/390 (20%), Positives = 168/390 (43%), Gaps = 26/390 (6%) Query: 97 SGVPVIRLAAGEPDFDTPKVVAEAGINAIR-EGFTRYTLNAGITELREAICRKLKEENGL 155 G +I L G + P+ + A+ +Y+ G L ++ + Sbjct: 55 QGRELINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNT 114 Query: 156 SYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKI- 214 + + V+ GA + +L ++ + + GDEVI+ P++ Y L V +P Sbjct: 115 ELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPP 174 Query: 215 ---------SNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHP 265 + +D + E +T K++ +I+ +P NP G V+ + L + I KH Sbjct: 175 KELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKH- 233 Query: 266 RLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYLAG-PKHI 324 ++++SDE+YEH+ + + P++ + TLTV K+FA TGWR+G++ + Sbjct: 234 NVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAEL 293 Query: 325 VAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLGDIKG 384 ++ +K ++ + S Q+A ++ G +M + Y + ++ G Sbjct: 294 LSYAAKAHTRICFASPSPLQEACANSINDALKIG-YFEKMRQEYINKFKIFTSIFDEL-G 351 Query: 385 VKISEPQGAFYLFIDFSAYYGSEAEGFG--LINDSSSLAL--YFLDKFQVAMVPGDAFG- 439 + + P+G +++ +DFS E + ++N + + +++ V +P F Sbjct: 352 LPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAIPPTEFYI 411 Query: 440 ------DDSCIRISYATSLDVLQAAVEKIR 463 ++ +R + L+ AVE+++ Sbjct: 412 KEHEKAAENLLRFAVCKDDAYLENAVERLK 441 >4IX8-A nrPDB Length = 444 Score = 277 bits (708), Expect = 7e-75, Method: Composition-based stats. Identities = 83/382 (21%), Positives = 164/382 (42%), Gaps = 25/382 (6%) Query: 102 IRLAAGEP----DFDTPKVVAEAGINAIREG-FTRYTLNAGITELREAICRKLKEE---- 152 +RL+ G+P + TP +V EA ++ +R G F Y G LR+ + + Sbjct: 70 LRLSIGDPTVDGNLKTPDIVTEAMVDVVRSGKFNGYPPTVGADNLRQVVSTYWRRFCQTK 129 Query: 153 -NGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADATPVVIP 211 + + +++++G Q+++ A+ A+C+ GD +++ AP + Y Sbjct: 130 SRQEALKWENVIITSGVSQAIVLALTALCNEGDNILVCAPSFPHYKSVCDSYGIECRYYY 189 Query: 212 TKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLS 271 S ++ D + + ++ ++ +PSNP GS + ++ + +I +H + ++S Sbjct: 190 LDPSKSWECDLRAAAGMVDSHTKAFVIINPSNPCGSNFSRAHVSDIIDFCQQHQ-IPLIS 248 Query: 272 DEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGY--LAGPKHIVAAC- 328 DEIY ++ TS A R + + G +K GWR+G+ L P ++ Sbjct: 249 DEIYAEMVLNNGIFTSVADFDTNVPRLI-LGGTAKYQVCPGWRVGWSILIDPMNVAGDWA 307 Query: 329 --SKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLGDIKGVK 386 + Q+ +G +SI Q+A A L K E +V + L G+ Sbjct: 308 VGMERLTQLIAGVNSICQEAI--ARTLLKCPTECTEHIVTQLEAGAKVYARLLEHDIGIS 365 Query: 387 ISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVAMVPGDAFGDDSCIRI 446 + PQ + ++ + + Y + + LD+ V ++PG+ FG +R Sbjct: 366 MEAPQASMFVMLKLNLSYFQD------LKSDMEFYEKLLDEENVQVLPGEIFGMSGFLRA 419 Query: 447 SYATSLDVLQAAVEKIRKALEP 468 + + VL AV++I + E Sbjct: 420 TVSRPSAVLNEAVDRIIEFCER 441 >2GB3-A nrPDB Length = 409 Score = 276 bits (707), Expect = 1e-74, Method: Composition-based stats. Identities = 101/406 (24%), Positives = 186/406 (45%), Gaps = 31/406 (7%) Query: 72 LSPRVQSLKPSKTMVITDLAATLVQSGVPVIRLAAGEPDFDTPKVVAEAGINAIREGFTR 131 S RV + S + A + GV + L G+PD TP+V E I + Sbjct: 16 FSDRVLLTEESPIRKLVPFAEMAKKRGVRIHHLNIGQPDLKTPEVFFER-IYENKPEVVY 74 Query: 132 YTLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAP 191 Y+ +AGI ELREA K + P+ +LV+NG +++L + + +PGDE+++ P Sbjct: 75 YSHSAGIWELREAFASYYKRRQRVDVKPENVLVTNGGSEAILFSFAVIANPGDEILVLEP 134 Query: 192 YWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPK 251 ++ +Y A++A + + ++ F + P++LES + E+++ ++L +P NPTG VY K Sbjct: 135 FYANYNAFAKIAGVKLIPVTRRMEEGFAI-PQNLESFINERTKGIVLSNPCNPTGVVYGK 193 Query: 252 SLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMT 311 + + I +H L ++ DE+Y I++ ++ L ++ + ++ SK F+ Sbjct: 194 DEMRYLVEIAERH-GLFLIVDEVYSEIVFRGEFASA---LSIESDKVVVIDSVSKKFSAC 249 Query: 312 GWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRER 371 G R+G L + + + Q + Q V L L + + V E YRER Sbjct: 250 GARVGCLITRNEELISHAMKLAQGRLAPPLLEQIGSVGLLNLDDSFFDFVRET---YRER 306 Query: 372 RDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQV- 430 + ++K L + + ++P GAFY+ + + D+ A + L F + Sbjct: 307 VETVLKKLEEHGLKRFTKPSGAFYITAELP------------VEDAEEFARWMLTDFNMD 354 Query: 431 ----AMVPGDAFG-----DDSCIRISYATSLDVLQAAVEKIRKALE 467 + P F IRI+ D+L A++ + + L+ Sbjct: 355 GETTMVAPLRGFYLTPGLGKKEIRIACVLEKDLLSRAIDVLMEGLK 400 >3FDB-A nrPDB Length = 377 Score = 276 bits (705), Expect = 2e-74, Method: Composition-based stats. Identities = 88/397 (22%), Positives = 163/397 (41%), Gaps = 32/397 (8%) Query: 74 PRVQSLKPSKTMVITDLAATLVQSGVPVIRLAAGEPDFDTPKVVAEAGINAIREGFTRYT 133 P ++ L+ TM T + G V+ L E DF T V +A +A++ Y Sbjct: 5 PSIEDLRARNTMKWT-------RYGQGVLPLWVAESDFSTCPAVLQAITDAVQREAFGYQ 57 Query: 134 LNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYW 193 + + L +A + G P+ I + L A+ +VI+P P + Sbjct: 58 PDGSL--LSQATAEFYADRYGYQARPEWIFPIPDVVRGLYIAIDHFTPAQSKVIVPTPAY 115 Query: 194 VSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSL 253 + + I ++ D+E +R ++LC+P NP G V+ Sbjct: 116 PPFFHLLSATQREGIFIDATGG----INLHDVEKGFQAGARSILLCNPYNPLGMVFAPEW 171 Query: 254 LEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGW 313 L E+ + ++ VL DEI+ +++ + +T+ SKA+ + G Sbjct: 172 LNELCDLAHRY-DARVLVDEIHAPLVFDGQHTVAAGVSDTAASVCITITAPSKAWNIAGL 230 Query: 314 RLGYLA-GPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERR 372 + + +L + GAS++ A AA + G + + + V + Sbjct: 231 KCAQIIFSNPSDAEHWQQLSPVIKDGASTLGLIAAEAAY---RYGTDFLNQEVAYLKNNH 287 Query: 373 DFLVKSL-GDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVA 431 DFL+ + I G KI+ Q + ++IDF + +F++K +VA Sbjct: 288 DFLLHEIPKRIPGAKITPMQATYLMWIDFRDTTIEGSPS-----------EFFIEKAKVA 336 Query: 432 MVPGDAFGDD--SCIRISYATSLDVLQAAVEKIRKAL 466 M G FG+D R+++ATS +VL+ A++++ KA+ Sbjct: 337 MNDGAWFGEDGTGFCRLNFATSREVLEEAIDRMAKAV 373 >1BW0-A nrPDB Length = 416 Score = 274 bits (701), Expect = 5e-74, Method: Composition-based stats. Identities = 106/423 (25%), Positives = 183/423 (43%), Gaps = 32/423 (7%) Query: 66 SSVDMSLSPRVQSLKPSKTMVITDLAATLVQSGVPVIRLAAGEPDFDTPKVVAEAGINAI 125 SS D+S+S L + ++D A S P+I+L+ G+P D + + A I + Sbjct: 2 SSWDVSMSNHA-GLVFNPIRTVSDNAKPSP-SPKPIIKLSVGDPTLDKNLLTSAAQIKKL 59 Query: 126 REGF-----TRYTLNAGITELREAICRKL------KEENGLSYAPDQILVSNGAKQSLLQ 174 +E Y G E REA+ KEE + D +++ +G +L Sbjct: 60 KEAIDSQECNGYFPTVGSPEAREAVATWWRNSFVHKEELKSTIVKDNVVLCSGGSHGILM 119 Query: 175 AVLAVCSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSR 234 A+ A+C GD ++P P + Y + + N++ D ++ +K++ Sbjct: 120 AITAICDAGDYALVPQPGFPHYETVCKAYGIGMHFYNCRPENDWEADLDEIRRLKDDKTK 179 Query: 235 LLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAP----ATHTSFAS 290 LLI+ +PSNP GS + + +E+I R+ + RL + SDEIY +++ AT TS A Sbjct: 180 LLIVTNPSNPCGSNFSRKHVEDIVRLA-EELRLPLFSDEIYAGMVFKGKDPNATFTSVAD 238 Query: 291 LPDMYERTLTVNGFSKAFAMTGWRLGYLA-----GPKHIVAACSKLQGQVSSGASSIAQK 345 R + + G +K + GWRLG+L G K G + G ++ Q Sbjct: 239 FETTVPRVI-LGGTAKNLVVPGWRLGWLLYVDPHGNGPSFLEGLKRVGMLVCGPCTVVQA 297 Query: 346 AGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYG 405 A AL E + ++V E +L +G+ G+ + P+GA YL Sbjct: 298 ALGEAL--LNTPQEHLDQIVAKIEESAMYLYNHIGECIGLAPTMPRGAMYLMSRI----- 350 Query: 406 SEAEGFGLINDSSSLALYFLDKFQVAMVPGDAFGDDSCIRISYATSLDVLQAAVEKIRKA 465 + E + I L++ V ++PG F R++ ++V + AVE+I+ Sbjct: 351 -DLEKYRDIKTDVEFFEKLLEEENVQVLPGTIFHAPGFTRLTTTRPVEVYREAVERIKAF 409 Query: 466 LEP 468 + Sbjct: 410 CQR 412 >3ASB-A nrPDB Length = 400 Score = 273 bits (698), Expect = 1e-73, Method: Composition-based stats. Identities = 109/417 (26%), Positives = 172/417 (41%), Gaps = 49/417 (11%) Query: 70 MSLSPRVQSLKPSKTMVITDLAATLVQSGVP-----VIRLAAGEPDFDTPKVVAEAGINA 124 M +P SL +K + DL + Q + VI L+ G+ VAEA ++ Sbjct: 1 MKRNPHFVSL--TKNYLFADLQKRVAQFRLENPQHTVINLSIGDTTQPLNASVAEAFASS 58 Query: 125 IRE-----GFTRYTLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAV 179 I Y + G+ LR+ + +I +S+GAK L + + + Sbjct: 59 IARLSSPTTCRGYGPDFGLPALRQKLSEDFYRGF---VDAKEIFISDGAKVDLFRLL-SF 114 Query: 180 CSPGDEVIIPAPYWVSYTEQARLADATPVV-IPTKISNNFLLDPKDLESKLTEKSRLLIL 238 P V I P + +Y + ARL A ++ +P N F + + +L L Sbjct: 115 FGPNQTVAIQDPSYPAYLDIARLTGAKEIIALPCLQENAFFPEFPE-----DTHIDILCL 169 Query: 239 CSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERT 298 CSP+NPTG+V K L I +H +L+L D Y I P+ S +PD Sbjct: 170 CSPNNPTGTVLNKDQLRAIVHYAIEHE-ILILFDAAYSTFISDPSLPKSIFEIPDARFCA 228 Query: 299 LTVNGFSKAFAMTGWRLGYLAGPKHIVAA--------CSKLQGQVSSGASSIAQKAGVAA 350 + +N FSK G RLG+ P+ + A + +GAS AQ+AGVA Sbjct: 229 IEINSFSKPLGFAGIRLGWTVIPQELTYADGHFVIQDWERFLSTTFNGASIPAQEAGVAG 288 Query: 351 LGLGKAGGETVAEMVKAYRERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEG 410 L + E + YRE D L K+L G ++ + A YL++ + S Sbjct: 289 LSILPQ-----LEAIHYYRENSDLLRKALLA-TGFEVFGGEHAPYLWVKPTQANIS---- 338 Query: 411 FGLINDSSSLALYFLDKFQVAMVPGDAFG--DDSCIRISYATSLDVLQAAVEKIRKA 465 L +FL ++ +A+ PG FG +R S + + AA E+++ A Sbjct: 339 ------DRDLFDFFLREYHIAITPGIGFGRSGSGFVRFSSLGKREDILAACERLQMA 389 >2ZC0-A nrPDB Length = 407 Score = 271 bits (692), Expect = 6e-73, Method: Composition-based stats. Identities = 93/413 (22%), Positives = 172/413 (41%), Gaps = 40/413 (9%) Query: 72 LSPRVQSLKPSKTMVITDLAATLVQSGVPVIRLAAGEPDFDTPKVVAEAGINAIREGFTR 131 L+ R +K S + A+ L + GV +I LAAG+PD P+++ A + I + Sbjct: 7 LAGRANWIKGSALADVMKKASELQKKGVKLISLAAGDPD---PELIPRAVLGEIAKEVLE 63 Query: 132 -------YTLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGD 184 YT GI ELRE + LK+ + L +P+ I+++ G +L + PGD Sbjct: 64 KEPKSVMYTPANGIPELREELAAFLKKYDHLEVSPENIVITIGGTGALDLLGRVLIDPGD 123 Query: 185 EVIIPAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTE------KSRLLI- 237 VI P +++ A +P + +D LE K+ E K +L+ Sbjct: 124 VVITENPSYINTLLAFEQLGAKIEGVPVDN-DGMRVDL--LEEKIKELKAKGQKVKLIYT 180 Query: 238 LCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYER 297 + + NP G + + I +K+ LL++ D Y + Y +L D R Sbjct: 181 IPTGQNPMGVTMSMERRKALLEIASKY-DLLIIEDTAYNFMRYEGGDIVPLKAL-DNEGR 238 Query: 298 TLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAG 357 + SK TG+R+G++ I+ + + A +I+Q + L G Sbjct: 239 VIVAGTLSKVLG-TGFRIGWIIAEGEILKKVLMQKQPIDFCAPAISQYIALEYLKRGYFE 297 Query: 358 GETVAEMVKAYRERRDFLVKSL-GDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLIND 416 + + Y+E+RD ++K+L + + ++P ++ D Sbjct: 298 KYHLEGALLGYKEKRDIMLKALENHLPNAEFTKPIAGMFVMFFLPEGA-----------D 346 Query: 417 SSSLALYFLDKFQVAMVPGDAFGDD----SCIRISYATS-LDVLQAAVEKIRK 464 S A +++ V +VPG F D + IR++++ + + ++K+ K Sbjct: 347 GISFANELMEREGVVVVPGKPFYTDESGKNAIRLNFSRPSKEEIPIGIKKLAK 399 >1C7O-A nrPDB Length = 399 Score = 269 bits (687), Expect = 2e-72, Method: Composition-based stats. Identities = 89/398 (22%), Positives = 170/398 (42%), Gaps = 32/398 (8%) Query: 85 MVITDLAATLVQSGVPVIRLAAGEPDFDTPKVVAEAGINAIREGFTRYTLNAGITELREA 144 + + + + G V+ L+ + +F P + E + E YT E ++ Sbjct: 17 LKWDLMYSQNPEVGNEVVPLSVADMEFKNPPELIEGLKKYLDETVLGYT--GPTEEYKKT 74 Query: 145 ICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLAD 204 + + +K+ + D I+ + G ++ AV PGD VII P + + + + Sbjct: 75 VKKWMKDRHQWDIQTDWIINTAGVVPAVFNAVREFTKPGDGVIIITPVYYPFFMAIKNQE 134 Query: 205 ATPVVIPTKISNN-FLLDPKDLESKLTEK-SRLLILCSPSNPTGSVYPKSLLEEIARIIA 262 + + + +D + LE +K ++ L+ CSP NP G V+ K L++I I+ Sbjct: 135 RKIIECELLEKDGYYTIDFQKLEKLSKDKNNKALLFCSPHNPVGRVWKKDELQKIKDIVL 194 Query: 263 KHPRLLVLSDEIYEHIIYAPATHTSFASLPD-MYERTLTVNGFSKAFAMTGWRLGYLAGP 321 K L++ SDEI+ +I HT F S+ + + ++T+T SK F + G G Sbjct: 195 K-SDLMLWSDEIHFDLIMPGYEHTVFQSIDEQLADKTITFTAPSKTFNIAGM------GM 247 Query: 322 KHIVAACSKLQGQVSSGASSIA-----QKAGVAALGLGKAGGETVAEMVKAYRERRDFLV 376 +I+ ++ + + + + A K G+ + +K + +V Sbjct: 248 SNIIIKNPDIRERFTKSRDATSGMPFTTLGYKACEICYKECGKWLDGCIKVIDKN-QRIV 306 Query: 377 KSLGDIKGVKISEP--QGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVAMVP 434 K ++ +I P +G + +IDF A L D ++ + + K Q+ Sbjct: 307 KDFFEVNHPEIKAPLIEGTYLQWIDFRA----------LKMDHKAMEEFMIHKAQIFFDE 356 Query: 435 GDAFGDD--SCIRISYATSLDVLQAAVEKIRKALEPLR 470 G FGD RI+ A V+Q ++E++ KAL+ L+ Sbjct: 357 GYIFGDGGIGFERINLAAPSSVIQESLERLNKALKDLK 394 >3ELE-A nrPDB Length = 398 Score = 268 bits (686), Expect = 3e-72, Method: Composition-based stats. Identities = 101/405 (24%), Positives = 169/405 (41%), Gaps = 48/405 (11%) Query: 82 SKTMVITD--LAATLVQSGVPVIRLAAGEPDFDTPKVVAEAGINAIRE----GFTRYTLN 135 S + + + V + G P P++V + + + YT Sbjct: 16 SAIRELFEYGKKRAAIVGKENVYDFSIGNPSIPAPQIVNDTIKELVTDYDSVALHGYTSA 75 Query: 136 AGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVC-SPGDEVIIPAPYWV 194 G E R AI L +G + D + ++ GA SL A+ DE I APY+ Sbjct: 76 QGDVETRAAIAEFLNNTHGTHFNADNLYMTMGAAASLSICFRALTSDAYDEFITIAPYFP 135 Query: 195 SYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLL 254 Y A A V +P +F +D LE ++ +R +I+ SP+NP+G+VY + + Sbjct: 136 EYKVFVNAAGARLVEVPADTE-HFQIDFDALEERINAHTRGVIINSPNNPSGTVYSEETI 194 Query: 255 EEIARIIAKHPR-----LLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFA 309 ++++ ++ K + + +++DE Y I+Y + Y+ TL +SK+ + Sbjct: 195 KKLSDLLEKKSKEIGRPIFIIADEPYREIVYDGIKVPF---VTKYYDNTLVCYSYSKSLS 251 Query: 310 MTGWRLGYLAGPKHI-------VAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVA 362 + G R+GY+ P + A C + A S+ QK V G Sbjct: 252 LPGERIGYVLVPDEVYDKAELYAAVCGAGRALGYVCAPSLFQKMIVKCQGATGD------ 305 Query: 363 EMVKAYRERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLAL 422 + AY+E RD L + L I G +P GAFY+F+ L +DS++ Sbjct: 306 --INAYKENRDLLYEGLTRI-GYHCFKPDGAFYMFVK------------ALEDDSNAFCE 350 Query: 423 YFLDKFQVAMVPGDAFGDDSCIRISYATSLDVLQA---AVEKIRK 464 + V +V D FG +RISY ++++ A EKI K Sbjct: 351 K-AKEEDVLIVAADGFGCPGWVRISYCVDREMIKHSMPAFEKIYK 394 >3QGU-A nrPDB Length = 449 Score = 260 bits (665), Expect = 8e-70, Method: Composition-based stats. Identities = 100/463 (21%), Positives = 182/463 (39%), Gaps = 58/463 (12%) Query: 33 QQPLRLSFSYCKSGNMSSRICAMAKPNDAETLSSSVDMSLSPRVQSLKPSKTMVITDLAA 92 Q +R + S +S S R+ A+ + + ++D+ + L+ + ++A Sbjct: 2 QLNVRSTASGARSSTRSRRMTAVVQA--VAQRAGTIDVQRNENFGKLRAG--YLFPEIAR 57 Query: 93 TLVQS-----GVPVIRLAAGEPDFDTPKVVAEAGINA-----IREGFTRYTLNAGITELR 142 +I L G+ PK +A+A A REG++ Y G LR Sbjct: 58 RRKAHQEKNPDAKIISLGIGDTTEPLPKYIADAMAKAAAGLATREGYSGYGAEQGQGALR 117 Query: 143 EAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARL 202 EA+ G A D+I +S+G+K + + + S V + P + Y + + + Sbjct: 118 EAVASTFYGHAGR--AADEIFISDGSKCDIARIQMMFGSK-PTVAVQDPSYPVYVDTSVM 174 Query: 203 ADATPV----------VIPTKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKS 252 T + N+F D +++ ++ CSP+NPTG+ ++ Sbjct: 175 MGMTGDHNGTGFDGIEYMVCNPDNHFFPDLSK-----AKRTDIIFFCSPNNPTGAAATRA 229 Query: 253 LLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTG 312 L E+ K+ +LV D Y I P + +P E + FSK TG Sbjct: 230 QLTELVNFARKNGSILVY-DAAYALYISNPDCPKTIYEIPGADEVAIETCSFSKYAGFTG 288 Query: 313 WRLGYLAGPK--------HIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEM 364 RLG+ PK + A +++ +GAS+I Q G+A L G + + M Sbjct: 289 VRLGWTVVPKALKYANGEPVHADWNRVMTTCFNGASNIVQAGGLACL--QPEGLKEMNAM 346 Query: 365 VKAYRERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYF 424 +K Y+E L + ++ G + A Y+++ F S + Sbjct: 347 IKFYKENAQILKTTFTEM-GFSVYGGDDAPYIWVGFPG------------KPSWDVFAEI 393 Query: 425 LDKFQVAMVPGDAFG--DDSCIRISYATSLDVLQAAVEKIRKA 465 L++ + PG +G + +R S S + + AV + ++A Sbjct: 394 LERCNIVTTPGSGYGPAGEGFVRASAFGSRENILEAVRRFKEA 436 >2DOU-A nrPDB Length = 376 Score = 257 bits (657), Expect = 7e-69, Method: Composition-based stats. Identities = 96/391 (24%), Positives = 173/391 (44%), Gaps = 23/391 (5%) Query: 80 KPSKTMVITDLAATLVQSGVPVIRLAAGEPDFDTPKVVAEAGINAIREGFT-RYTLNAGI 138 +PS +V+ + + GV +I L+ G D P+ +A A+ + T Y L + Sbjct: 6 EPSVFLVVDEAKRKARERGVGLIDLSIGSTDLPPPEAPLKALAEALNDPTTYGYCLKSCT 65 Query: 139 TELREAICRKLKEENGLSYAPD-QILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYT 197 E R + G+ P + L G+++ L +LA+ P D +++P + SY Sbjct: 66 LPFLEEAARWYEGRYGVGLDPRREALALIGSQEGLAHLLLALTEPEDLLLLPEVAYPSYF 125 Query: 198 EQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEI 257 AR+A +IP + + L D K + + ++++L+L P+NPTG+V EE Sbjct: 126 GAARVASLRTFLIPLRE--DGLADLKAVPEGVWREAKVLLLNYPNNPTGAVADWGYFEEA 183 Query: 258 ARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGY 317 + KH L ++ D Y +Y + A LP ER + + SK++ + G+RLG+ Sbjct: 184 LGLARKH-GLWLIHDNPYVDQVYEGEAPSPLA-LPGAKERVVELFSLSKSYNLAGFRLGF 241 Query: 318 LAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVK 377 G + +A +++G + + + GV AL K E V + YRER + + Sbjct: 242 ALGSEEALARLERVKGVIDFNQYAGVLRMGVEAL---KTPKEVVRGYARVYRERALGMAE 298 Query: 378 SLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDK-FQVAMVPGD 436 +L + + + P+ YL+ D L +++ +A G Sbjct: 299 ALKGV--LSLLPPRATMYLWGRLPEGV-----------DDLEFGLRLVERGVALAPGRGF 345 Query: 437 AFGDDSCIRISYATSLDVLQAAVEKIRKALE 467 G +RI+ L+ L A ++IR+AL+ Sbjct: 346 GPGGKGFVRIALVRPLEELLEAAKRIREALD 376 >4FL0-A nrPDB Length = 456 Score = 255 bits (651), Expect = 3e-68, Method: Composition-based stats. Identities = 91/405 (22%), Positives = 162/405 (40%), Gaps = 52/405 (12%) Query: 89 DLAATLVQSGVPVIRLAAGEPDFDTPKVVAEAGINAIR-----EGFTRYTLNAGITELRE 143 +L V +I L G+ P+ + N EG+ Y L G LR+ Sbjct: 60 ELEHIEKHPNVQLISLGTGDTTEPIPEQITSHMSNFAHGLSTVEGYRGYGLEQGNKTLRK 119 Query: 144 AICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLA 203 AI + L +++ VS+GA+ + + + + + + P + +Y + + + Sbjct: 120 AIAETFYRD--LHVKSNEVFVSDGAQSDISR-LQLLLGSNVTIAVQDPTFPAYIDSSVII 176 Query: 204 DAT------------PVVIPTKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPK 251 T V +P +N+F D +T ++ ++ CSP+NPTG V + Sbjct: 177 GQTGHFHEKTKKYQNVVYMPCGPNNSFFPDL-----AMTPRTDVIFFCSPNNPTGYVASR 231 Query: 252 SLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMT 311 L ++ K +++ D Y I + S +P E + V+ FSK T Sbjct: 232 KQLHQLVDFA-KTNGSIIIFDSAYAAFI-EDGSPRSIYEIPGAREVAIEVSSFSKFAGFT 289 Query: 312 GWRLGYLAGPKH--------IVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAE 363 G RLG+ P I+ ++ +GAS+IAQ G+A L G G + + Sbjct: 290 GVRLGWSIIPDELLYSNGFPIINDFHRIVTTSFNGASNIAQAGGLACLSSG--GLKEIRS 347 Query: 364 MVKAYRERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALY 423 + Y+E R L+ +L + G+K+ A YL++ F S + Sbjct: 348 VNNYYKENRKILMDTLVSL-GLKVYGGVNAPYLWVHFKGSK------------SWDVFNE 394 Query: 424 FLDKFQVAMVPGDAF--GDDSCIRISYATSLDVLQAAVEKIRKAL 466 L+ + VPG F G + +RIS D + A ++++ Sbjct: 395 ILENTHIITVPGSGFGPGGEEYLRISGFGRRDHIVEASKRLQNFF 439 >3JTX-A nrPDB Length = 396 Score = 254 bits (648), Expect = 6e-68, Method: Composition-based stats. Identities = 93/407 (22%), Positives = 172/407 (42%), Gaps = 41/407 (10%) Query: 76 VQSLKPSKTMVITD-LAATLVQSGVPVIRLAAGEPDFDTPKVVAEAGINAIREGFTRYTL 134 ++ LKP + + + G+ + L GEP TPKV+ +A ++ E +Y L Sbjct: 6 LKQLKPYPFARLHEAMQGISAPEGMEAVPLHIGEPKHPTPKVITDALTASLHE-LEKYPL 64 Query: 135 NAGITELREAICRKLKEEN-GLSYAPDQ-ILVSNGAKQSLLQAVLAVCSP-----GDEVI 187 AG+ ELR+A LK GL+ D IL G++++L V V +P ++ Sbjct: 65 TAGLPELRQACANWLKRRYDGLTVDADNEILPVLGSREALFSFVQTVLNPVSDGIKPAIV 124 Query: 188 IPAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGS 247 P P++ Y E A L + + +F D + + ++ ++++L+ +CSP+NP+GS Sbjct: 125 SPNPFYQIY-EGATLLGGGEIHFANCPAPSFNPDWRSISEEVWKRTKLVFVCSPNNPSGS 183 Query: 248 VYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAP----ATHTSFASLPDMYERTLTVNG 303 V +E+ + K+ ++ SDE Y I + + A L ++ L Sbjct: 184 VLDLDGWKEVFDLQDKY-GFIIASDECYSEIYFDGNKPLGCLQAAAQLGRSRQKLLMFTS 242 Query: 304 FSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAE 363 SK + G R G++AG ++ + S S Q+A +AA + V + Sbjct: 243 LSKRSNVPGLRSGFVAGDAELLKNFLLYRTYHGSAMSIPVQRASIAAWD----DEQHVID 298 Query: 364 MVKAYRERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALY 423 + Y+E+ + ++ L + VK+ P +FY+++ D + A Sbjct: 299 NRRLYQEKFERVIPILQQVFDVKL--PDASFYIWLKVPDG------------DDLAFARN 344 Query: 424 FLDKFQVAMVPGD--------AFGDDSCIRISYATSLDVLQAAVEKI 462 K + ++PG + +RI+ + A E I Sbjct: 345 LWQKAAIQVLPGRFLARDTEQGNPGEGYVRIALVADVATCVKAAEDI 391 >3AV7-A nrPDB Length = 448 Score = 249 bits (635), Expect = 2e-66, Method: Composition-based stats. Identities = 91/430 (21%), Positives = 193/430 (44%), Gaps = 45/430 (10%) Query: 62 ETLSSSVDMSLSPRVQSLKPSKTMVITDLAATLVQSGVPVIRLAAGEPDFDT-PKVVAEA 120 +++ V+ S + ++ S+ + L T +I LA G P+ T PK + Sbjct: 44 KSMLGDVERFFSKKALEMRASEVRELLKLVET-----SDIISLAGGLPNPKTFPKEIIRD 98 Query: 121 GINAIREGF----TRYTLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAV 176 + I E + +Y G T LRE + + L + G+S D I++++G++Q+L Sbjct: 99 ILVEIMEKYADKALQYGTTKGFTPLRETLMKWLGKRYGISQDND-IMITSGSQQALDLIG 157 Query: 177 LAVCSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTE----- 231 +PGD V++ AP +++ + + + IP + + LE KL E Sbjct: 158 RVFLNPGDIVVVEAPTYLAALQAFNFYEPQYIQIPLDDE---GMKVEILEEKLKELKSQG 214 Query: 232 -KSRLLI-LCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFA 289 K +++ + + NP G + + + + +++ +V+ D+ Y + Y+ Sbjct: 215 KKVKVVYTVPTFQNPAGVTMNEDRRKYLLELASEY-DFIVVEDDPYGELRYSGNPEKKIK 273 Query: 290 SLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVA 349 +L D R + + FSK A G+R+G++ G I+ ++ Q + +++ + Sbjct: 274 AL-DNEGRVIYLGTFSKILA-PGFRIGWMVGDPGIIRKM-EIAKQSTDLCTNVFGQVVAW 330 Query: 350 ALGLGKAGGETVAEMVKAYRERRDFLVKSLGDI--KGVKISEPQGAFYLFIDFSAYYGSE 407 G + + E+ K Y+ RRD ++++L + +GVK ++P+G ++++ Sbjct: 331 RYVDGGYLEKHIPEIRKFYKPRRDAMLEALEEFMPEGVKWTKPEGGMFIWVTLPDGI--- 387 Query: 408 AEGFGLINDSSSLALYFLDKFQVAMVPGDAFGD----DSCIRISYA-TSLDVLQAAVEKI 462 DS + + K VA VPG+AF + +R+++ D + ++++ Sbjct: 388 --------DSKKMLERAIKK-GVAYVPGEAFYAHRDVKNTMRLNFTYVDEDKIMEGIKRL 438 Query: 463 RKAL-EPLRA 471 + + E L+A Sbjct: 439 AETIKEELKA 448 >1X0M-A nrPDB Length = 403 Score = 248 bits (632), Expect = 5e-66, Method: Composition-based stats. Identities = 91/428 (21%), Positives = 191/428 (44%), Gaps = 45/428 (10%) Query: 64 LSSSVDMSLSPRVQSLKPSKTMVITDLAATLVQSGVPVIRLAAGEPDFDT-PKVVAEAGI 122 + V+ S + ++ S+ + L T +I LA G P+ T PK + + Sbjct: 1 MLGDVERFFSKKALEMRASEVRELLKLVET-----SDIISLAGGLPNPKTFPKEIIRDIL 55 Query: 123 NAIREGF----TRYTLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLA 178 I E + +Y G T LRE + + L + G+S D I++++G++Q+L Sbjct: 56 VEIMEKYADKALQYGTTKGFTPLRETLMKWLGKRYGISQDND-IMITSGSQQALDLIGRV 114 Query: 179 VCSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTE------K 232 +PGD V++ AP +++ + + + IP + + LE KL E K Sbjct: 115 FLNPGDIVVVEAPTYLAALQAFNFYEPQYIQIPLDDE---GMKVEILEEKLKELKSQGKK 171 Query: 233 SRLLI-LCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASL 291 +++ + + NP G + + + + +++ +V+ D+ Y + Y+ +L Sbjct: 172 VKVVYTVPTFQNPAGVTMNEDRRKYLLELASEY-DFIVVEDDPYGELRYSGNPEKKIKAL 230 Query: 292 PDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAAL 351 D R + + FSK A G+R+G++ G I+ ++ Q + +++ + Sbjct: 231 -DNEGRVIYLGTFSKILA-PGFRIGWMVGDPGIIRKM-EIAKQSTDLCTNVFGQVVAWRY 287 Query: 352 GLGKAGGETVAEMVKAYRERRDFLVKSLGDI--KGVKISEPQGAFYLFIDFSAYYGSEAE 409 G + + E+ K Y+ RRD ++++L + +GVK ++P+G ++++ Sbjct: 288 VDGGYLEKHIPEIRKFYKPRRDAMLEALEEFMPEGVKWTKPEGGMFIWVTLPDGI----- 342 Query: 410 GFGLINDSSSLALYFLDKFQVAMVPGDAFGD----DSCIRISYA-TSLDVLQAAVEKIRK 464 DS + + K VA VPG+AF + +R+++ D + ++++ + Sbjct: 343 ------DSKKMLERAIKK-GVAYVPGEAFYAHRDVKNTMRLNFTYVDEDKIMEGIKRLAE 395 Query: 465 AL-EPLRA 471 + E L+A Sbjct: 396 TIKEELKA 403 >3OP7-A nrPDB Length = 375 Score = 243 bits (619), Expect = 2e-64, Method: Composition-based stats. Identities = 69/350 (19%), Positives = 136/350 (38%), Gaps = 25/350 (7%) Query: 119 EAGINAIREGFTRYTLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLA 178 E ++ Y G ++++ + P+QIL +NGA + L + + Sbjct: 46 EDFYKKLQGTKLNYGWIEGSPAFKKSVSQLYT-----GVKPEQILQTNGATGANLLVLYS 100 Query: 179 VCSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLIL 238 + PGD VI P + + + A + + N +L D + L + ++++ + Sbjct: 101 LIEPGDHVISLYPTYQQLYDIPKSLGAEVDLWQIEEENGWLPDLEKLRQLIRPTTKMICI 160 Query: 239 CSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERT 298 + +NPTG+V ++ LEE+ I ++ +LSDE+Y + S+ ++Y++ Sbjct: 161 NNANNPTGAVMDRTYLEELVEIASE-VGAYILSDEVYRSF-----SELDVPSIIEVYDKG 214 Query: 299 LTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGG 358 + VN SK +++ G R+G++A + + A AL Sbjct: 215 IAVNSLSKTYSLPGIRIGWVAANHQVTDILRDYRDYTMICAGVFDDLVAQLALA---HYQ 271 Query: 359 ETVAEMVKAYRERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSS 418 E + E L + + + V P A + + Sbjct: 272 EILERNRHILEENLAILDQWIEEEPLVSYIRP-----------AVVSTSFVKIAVDMPME 320 Query: 419 SLALYFLDKFQVAMVPGDAFGDDSCIRISYATSLDVLQAAVEKIRKALEP 468 L L + V +VPG+ F D +R+ +A + L +EK+ + L Sbjct: 321 DFCLQLLQEHGVLLVPGNRFERDGYVRLGFACEQETLIKGLEKLSQFLRR 370 >3DZZ-A nrPDB Length = 391 Score = 240 bits (611), Expect = 1e-63, Method: Composition-based stats. Identities = 64/369 (17%), Positives = 152/369 (41%), Gaps = 20/369 (5%) Query: 102 IRLAAGEPDFDTPKVVAEAGINAIREGFTRYTLNAGITELREAICRKLKEENGLSYAPDQ 161 + + E DF + + ++ Y E +A+ + E+ D Sbjct: 30 LPMWIAEMDFKIAPEIMASMEEKLKVAAFGYESVPA--EYYKAVADWEEIEHRARPKEDW 87 Query: 162 ILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNN-FLL 220 + ++G ++ V SPGD++++ P + + + N+ + + Sbjct: 88 CVFASGVVPAISAMVRQFTSPGDQILVQEPVYNMFYSVIEGNGRRVISSDLIYENSKYSV 147 Query: 221 DPKDLESKL-TEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHII 279 + DLE KL T R+++ C+P NP G + + ++ IA + AKH +L++SDEI+ ++ Sbjct: 148 NWADLEEKLATPSVRMMVFCNPHNPIGYAWSEEEVKRIAELCAKHQ-VLLISDEIHGDLV 206 Query: 280 YAPATHTSFASLP-DMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSG 338 T ++ D +++ SK F + P + A ++ + +G Sbjct: 207 LTDEDITPAFTVDWDAKNWVVSLISPSKTFNLAALHAACAIIPNPDLRARAE-ESFFLAG 265 Query: 339 ASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLG-DIKGVKISEPQGAFYLF 397 A AA+ + G + + E+ + R+ + + L ++ VK+ + ++ + Sbjct: 266 IGEPNLLAIPAAIAAYEEGHDWLRELKQVLRDNFAYAREFLAKEVPEVKVLDSNASYLAW 325 Query: 398 IDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVAMVPGDAFGDDS--CIRISYATSLDVL 455 +D SA ++ Y +K + + G+ + + +RI+ A +++ Sbjct: 326 VDISALG----------MNAEDFCKYLREKTGLIISAGNGYRGNGHEFVRINLACPKELV 375 Query: 456 QAAVEKIRK 464 ++++++ Sbjct: 376 IDGMQRLKQ 384 >1IAY-A nrPDB Length = 428 Score = 232 bits (591), Expect = 3e-61, Method: Composition-based stats. Identities = 73/352 (20%), Positives = 144/352 (40%), Gaps = 27/352 (7%) Query: 134 LNAGITELREAICRKLKEENG--LSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAP 191 G+ E R+AI + +++ G + + P++++++ GA + + + PGD ++P+P Sbjct: 81 DYHGLPEFRKAIAKFMEKTRGGRVRFDPERVVMAGGATGANETIIFCLADPGDAFLVPSP 140 Query: 192 YWVSYTEQARLA-DATPVVIPTKISNNFLLDPKDLESKLTE------KSRLLILCSPSNP 244 Y+ ++ R + I + SNNF + K ++ K + LIL +PSNP Sbjct: 141 YYPAFNRDLRWRTGVQLIPIHCESSNNFKITSKAVKEAYENAQKSNIKVKGLILTNPSNP 200 Query: 245 TGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTL----- 299 G+ K L+ + +H + ++ DEIY ++ S A + D E T Sbjct: 201 LGTTLDKDTLKSVLSFTNQH-NIHLVCDEIYAATVFDTPQFVSIAEILDEQEMTYCNKDL 259 Query: 300 --TVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAG 357 V SK + G+R+G + V C++ S+ Q A L K Sbjct: 260 VHIVYSLSKDMGLPGFRVGIIYSFNDDVVNCARKMSSFGL-VSTQTQYFLAAMLSDEKFV 318 Query: 358 GETVAEMVKAYRERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDS 417 + E +R L ++ G+K + + ++D + Sbjct: 319 DNFLRESAMRLGKRHKHFTNGL-EVVGIKCLKNNAGLFCWMDLRPLLREST-----FDSE 372 Query: 418 SSLALYFLDKFQVAMVPGDAFG--DDSCIRISYATSLD-VLQAAVEKIRKAL 466 SL ++ ++ + PG +F + R+ +A D + A+ +IR+ + Sbjct: 373 MSLWRVIINDVKLNVSPGSSFECQEPGWFRVCFANMDDGTVDIALARIRRFV 424 >3EI8-A nrPDB Length = 432 Score = 230 bits (587), Expect = 8e-61, Method: Composition-based stats. Identities = 79/412 (19%), Positives = 154/412 (37%), Gaps = 57/412 (13%) Query: 85 MVITDLAAT-----LVQSGVPVIRLAAGEPDFDTPKVVAEAGINAIRE-----GFTRYTL 134 + ++A L VI L G+ P+V+ A E G++ Y Sbjct: 37 YLFPEIARRRSAHLLKYPDAQVISLGIGDTTEPIPEVITSAMAKKAHELSTIEGYSGYGA 96 Query: 135 NAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWV 194 G LR AI + GL D + VS+GAK + + + S + + P + Sbjct: 97 EQGAKPLRAAIAKTFY--GGLGIGDDDVFVSDGAKCDISRLQVMFGS-NVTIAVQDPSYP 153 Query: 195 SYTEQARLADATPVV------------IPTKISNNFLLDPKDLESKLTEKSRLLILCSPS 242 +Y + + + T + N F D + ++ ++ CSP+ Sbjct: 154 AYVDSSVIMGQTGQFNTDVQKYGNIEYMRCTPENGFFPDLSTV-----GRTDIIFFCSPN 208 Query: 243 NPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVN 302 NPTG+ + L ++ K+ + ++ D Y + + F +P E + Sbjct: 209 NPTGAAATREQLTQLVEFAKKNGSI-IVYDSAYAMYMSDDNPRSIF-EIPGAEEVAMETA 266 Query: 303 GFSKAFAMTGWRLGYLAGPKHIV--------AACSKLQGQVSSGASSIAQKAGVAALGLG 354 FS TG RLG+ PK ++ +++ +GAS+I+Q +A L Sbjct: 267 SFSNYAGFTGVRLGWTVIPKKLLYSDGFPVAKDFNRIICTCFNGASNISQAGALACLT-- 324 Query: 355 KAGGETVAEMVKAYRERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLI 414 G E + +++ Y+E + ++ + + G + + A Y+++ F Sbjct: 325 PEGLEAMHKVIGFYKENTNIIIDTFTSL-GYDVYGGKNAPYVWVHFP------------N 371 Query: 415 NDSSSLALYFLDKFQVAMV--PGDAFGDDSCIRISYATSLDVLQAAVEKIRK 464 S + L+K V G G + +R+S + + A + ++ Sbjct: 372 QSSWDVFAEILEKTHVVTTPGSGFGPGGEGFVRVSAFGHRENILEACRRFKQ 423 >3IHJ-A nrPDB Length = 498 Score = 226 bits (577), Expect = 1e-59, Method: Composition-based stats. Identities = 80/438 (18%), Positives = 156/438 (35%), Gaps = 62/438 (14%) Query: 89 DLAATLVQSGVPVIRLAAGE---------------------PDFDTPKVVAEAGINAIRE 127 +L + + VIR G+ P+ E R Sbjct: 53 ELQRGIKKPFTEVIRANIGDAQAMGQQPITFLRQVMALCTYPNLLDSPSFPEDAKKRARR 112 Query: 128 --------GFTRYTLNAGITELREAICRKLKEENG-LSYAPDQILVSNGAKQSLLQAVLA 178 Y+ + G+ +RE + + +G + PD I ++ GA + + Sbjct: 113 ILQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPADPDNIYLTTGASDGISTILKI 172 Query: 179 VCSPGDE----VIIPAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTE--- 231 + S G + V+IP P + Y+ DA V N + L+ +L + E Sbjct: 173 LVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCWALNVNELRRAVQEAKD 232 Query: 232 --KSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPAT--HTS 287 ++L + +P NPTG V + +E++ +L +L+DE+Y+ +Y+P H+ Sbjct: 233 HCDPKVLCIINPGNPTGQVQSRKCIEDVIHFA-WEEKLFLLADEVYQDNVYSPDCRFHSF 291 Query: 288 FASLPDM---YERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSS-----GA 339 L +M Y + + F GY G ++ +++GQ+ Sbjct: 292 KKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQLVKLLSVRLC 351 Query: 340 SSIAQKAGVAALGLGKAGGETVAEMVKAYRE--------RRDFLVKSLGDIKGVKISEPQ 391 ++ +A + + GE E +E + + G+ + Q Sbjct: 352 PPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKLTEDLFNQVPGIHCNPLQ 411 Query: 392 GAFYLFID-FSAYYGSEAEGFGLINDSSSLALYFLDKFQVAMVPGDAFGDDS---CIRIS 447 GA Y F F EA + + L++ + +VPG FG R++ Sbjct: 412 GAMYAFPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEETGICVVPGSGFGQREGTYHFRMT 471 Query: 448 YATSLDVLQAAVEKIRKA 465 ++ L+ ++K++ Sbjct: 472 ILPPVEKLKTVLQKVKDF 489 >1WST-A nrPDB Length = 417 Score = 226 bits (576), Expect = 2e-59, Method: Composition-based stats. Identities = 76/418 (18%), Positives = 177/418 (42%), Gaps = 37/418 (8%) Query: 67 SVDMSLSPRVQSLKPSKTMVITDLAATLVQSGVPVIRLAAGEPDFDT--PKVVAEAGINA 124 + D S + +K S+ + L T VI LA G P +T + + + + Sbjct: 14 NFDSFFSEKAMLMKASEVRELLKLVET-----SDVISLAGGLPAPETFPVETIKKIAVEV 68 Query: 125 IREGFT---RYTLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCS 181 + E +Y G T LR A+ R +++ + + +I+ G++Q+L + Sbjct: 69 LEEHADKALQYGTTKGFTPLRLALARWMEKRYDIPMSKVEIMTVAGSQQALDLIGRVFLN 128 Query: 182 PGDEVIIPAPYWVSYTEQARLADATPVVIPTK---ISNNFLLDPKDLESKLTEKSRLLI- 237 PGD +++ AP +++ + + D + IP + + L + + K ++ +++ Sbjct: 129 PGDPIVVEAPTYLAAIQAFKYYDPEFISIPLDDKGMRVDLLEEKLEELRKQGKRVKIVYT 188 Query: 238 LCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYER 297 + + NP G +++ + ++ L++ D Y + Y+ D Y R Sbjct: 189 VSTFQNPAGVTMSVDRRKKLLELANEY-DFLIVEDGPYSELRYSGEPTPPIKHFDD-YGR 246 Query: 298 TLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAG 357 + + FSK A G+R+G++A H++ + + ++ Q A Sbjct: 247 VIYLGTFSKILA-PGFRIGWVAAHPHLIRKMEIAKQSIDLCTNTFGQ-AIAWKYVENGYL 304 Query: 358 GETVAEMVKAYRERRDFLVKSLGD--IKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLIN 415 E + ++++ Y+ RRD ++++L + +GV+ ++P+G ++ + Sbjct: 305 DEHIPKIIEFYKPRRDAMLEALEEYMPEGVEWTKPEGGMFVRVTLPEGI----------- 353 Query: 416 DSSSLALYFLDKFQVAMVPGDAF----GDDSCIRISYA-TSLDVLQAAVEKIRKALEP 468 + L + VA VPG+AF + +R+++ + ++ V ++ + ++ Sbjct: 354 -DTKLMMERAVAKGVAYVPGEAFFVHRDKKNTMRLNFTYVPEETIREGVRRLAETIKE 410 >1D2F-A nrPDB Length = 390 Score = 221 bits (564), Expect = 4e-58, Method: Composition-based stats. Identities = 70/378 (18%), Positives = 154/378 (40%), Gaps = 23/378 (6%) Query: 100 PVIRLAAGEPDFDTPKVVAEAGINAIREGFTRYTLNAGITELREAICRKLKEENGLSYAP 159 ++ + DF T + EA + G Y+ E AI ++ + Sbjct: 29 DLLPFTISDMDFATAPCIIEALNQRLMHGVFGYSRWK-NDEFLAAIAHWFSTQHYTAIDS 87 Query: 160 DQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADATPVVIPT-KISNNF 218 ++ + + + G+ V+I P + ++ + T + + K ++ + Sbjct: 88 QTVVYGPSVIYMVSELIRQWSETGEGVVIHTPAYDAFYKAIEGNQRTVMPVALEKQADGW 147 Query: 219 LLDPKDLESKL-TEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEH 277 D LE+ L + ++++LCSP NPTG V+ LE +A + +H + V+SDEI+ Sbjct: 148 FCDMGKLEAVLAKPECKIMLLCSPQNPTGKVWTCDELEIMADLCERH-GVRVISDEIHMD 206 Query: 278 IIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGW--RLGYLAGPKHIVAACSKLQGQV 335 +++ H ++++ + L +G SK+F + G + A S L+G+ Sbjct: 207 MVWGEQPHIPWSNVARG-DWALLTSG-SKSFNIPALTGAYGIIENSSSRDAYLSALKGR- 263 Query: 336 SSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLGDI-KGVKISEPQGAF 394 G SS + A A + + G + + ++ ++ + + PQ + Sbjct: 264 -DGLSSPSVLALTAHIAAYQQGAPWLDALRIYLKDNLTYIADKMNAAFPELNWQIPQSTY 322 Query: 395 YLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVAMVPGDAFGDD--SCIRISYATSL 452 ++D D ++L +++ +VA++PG +G++ +R++ Sbjct: 323 LAWLDLRPLNI----------DDNALQKALIEQEKVAIMPGYTYGEEGRGFVRLNAGCPR 372 Query: 453 DVLQAAVEKIRKALEPLR 470 L+ V + A+ +R Sbjct: 373 SKLEKGVAGLINAIRAVR 390 >2ZYJ-A nrPDB Length = 397 Score = 216 bits (551), Expect = 1e-56, Method: Composition-based stats. Identities = 83/420 (19%), Positives = 165/420 (39%), Gaps = 55/420 (13%) Query: 73 SPRVQSLKPSKTMVITDLAATLVQSGVPVIRLAAGEPDFDTPKVVAE--------AGINA 124 + R+Q+ + + +T ++ A G P P++ + + Sbjct: 14 AGRIQASTIRELLKLTQR--------PGILSFAGGLP---APELFPKEEAAEAAARILRE 62 Query: 125 IREGFTRYTLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGD 184 E +Y+ G LR + + P+++L++ G++Q+L G Sbjct: 63 KGEVALQYSPTEGYAPLRAFVAEW------IGVRPEEVLITTGSQQALDLVGKVFLDEGS 116 Query: 185 EVIIPAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLT-EKSRLLILC-SPS 242 V++ AP ++ + RL + +P D LE L E+ R L L S Sbjct: 117 PVLLEAPSYMGAIQAFRLQGPRFLTVPAGEE---GPDLDALEEVLKRERPRFLYLIPSFQ 173 Query: 243 NPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDM--YERTLT 300 NPTG + P + + +++ + L+V+ D+ Y + + A S L Y + Sbjct: 174 NPTGGLTPLPARKRLLQMVMER-GLVVVEDDAYRELYFGEARLPSLFELAREAGYPGVIY 232 Query: 301 VNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGET 360 + FSK + G R+ + + + + + Q L + E Sbjct: 233 LGSFSKVLS-PGLRVAFAVAHPEALQKLVQAKQGADLHTPMLNQMLVHELLK--EGFSER 289 Query: 361 VAEMVKAYRERRDFLVKSLGDI--KGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSS 418 + + + YRE+ ++ +L K V+ + P+G +++++ +E Sbjct: 290 LERVRRVYREKAQAMLHALDREVPKEVRYTRPKGGMFVWMELPKGLSAEG---------- 339 Query: 419 SLALYFLDKFQVAMVPGDAF----GDDSCIRISYAT-SLDVLQAAVEKIRKALEPLRATV 473 L L++ VA VPG F G ++ +R+SYAT + + V ++ +AL+ L A V Sbjct: 340 -LFRRALEE-NVAFVPGGPFFANGGGENTLRLSYATLDREGIAEGVRRLGRALKGLLALV 397 >4M2J-A nrPDB Length = 406 Score = 213 bits (542), Expect = 2e-55, Method: Composition-based stats. Identities = 67/340 (19%), Positives = 129/340 (37%), Gaps = 17/340 (5%) Query: 133 TLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPY 192 +++ G +R AI + D++LV++G+ +++ + A+ GD V++ Sbjct: 81 SVSQGGEGVRRAIADRYA-----GGDADRVLVTHGSSEAIALTLNALLHRGDRVVVQEGI 135 Query: 193 WVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKS 252 + S R A V+P + + +DP L +T + +I+ P NPTG Sbjct: 136 YHSLGHYPRAAGCDVAVLPGRAVRDGEIDPDVLAGLVTPGTAAVIVNFPHNPTGVTLSPQ 195 Query: 253 LLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTG 312 L + A +LV D I A T++ SK F + G Sbjct: 196 GLRALKERTAATGAVLVW-DAATAEIA---HRWEVLADPGADGGDTVSYGTLSKTFGLPG 251 Query: 313 WRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERR 372 R+G+ PK ++ A L+ + + S + + A+ + E + R Sbjct: 252 LRVGWAVAPKELLTATFPLRDRTTLFLSPLVELVAERAV---RHADELIGARAAEARHNL 308 Query: 373 DFLVKSLGDIKG-VKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVA 431 L + + V+ + P+G F + A + L L++ + Sbjct: 309 AHLTGWMAAHEELVRWTPPEGGVCALPVFRELERAAAGP----QEVERFCLELLERHRTL 364 Query: 432 MVPGDAFGDDSCIRISYATSLDVLQAAVEKIRKALEPLRA 471 +VPG AFG R+ + + +A ++ + + L A Sbjct: 365 LVPGTAFGAPHGARLGFGGPQEDFRAGLDGLSRFLRERAA 404 >1M4N-A nrPDB Length = 435 Score = 213 bits (541), Expect = 2e-55, Method: Composition-based stats. Identities = 65/354 (18%), Positives = 138/354 (38%), Gaps = 29/354 (8%) Query: 134 LNAGITELREAICRKLK--EENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAP 191 G+ ++A+ + N +++ P+ ++++ GA + + + PG+ V+IP P Sbjct: 84 DYHGLPAFKKAMVDFMAEIRGNKVTFDPNHLVLTAGATSANETFIFCLADPGEAVLIPTP 143 Query: 192 YWVSYTEQARLA-DATPVVIPTKISNNFLLDPKDLESKLTE------KSRLLILCSPSNP 244 Y+ + + V I SN F + LE E + + +++ +PSNP Sbjct: 144 YYPGFDRDLKWRTGVEIVPIHCTSSNGFQITETALEEAYQEAEKRNLRVKGVLVTNPSNP 203 Query: 245 TGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASL---------PDMY 295 G+ ++ L + + + + ++SDEIY ++ + S + +++ Sbjct: 204 LGTTMTRNELYLLLSFV-EDKGIHLISDEIYSGTAFSSPSFISVMEVLKDRNCDENSEVW 262 Query: 296 ERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGK 355 +R V SK + G+R+G + +V A + SS Q A L K Sbjct: 263 QRVHVVYSLSKDLGLPGFRVGAIYSNDDMVVAAATKMSSFGL-VSSQTQHLLSAMLSDKK 321 Query: 356 AGGETVAEMVKAYRERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLIN 415 +AE K ++R+ LV L G+ + ++D S Sbjct: 322 LTKNYIAENHKRLKQRQKKLVSGLQK-SGISCLNGNAGLFCWVDMRHLLRSNT-----FE 375 Query: 416 DSSSLALYFLDKFQVAMVPGDAFG--DDSCIRISYAT-SLDVLQAAVEKIRKAL 466 L + + + + PG + + R+ +A L A+++++ + Sbjct: 376 AEMELWKKIVYEVHLNISPGSSCHCTEPGWFRVCFANLPERTLDLAMQRLKAFV 429 >3TCM-A nrPDB Length = 500 Score = 207 bits (527), Expect = 8e-54, Method: Composition-based stats. Identities = 78/374 (20%), Positives = 140/374 (37%), Gaps = 31/374 (8%) Query: 127 EGFTRYTLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVC-SPGDE 185 Y+ + GI LR+AI + +G D I +++GA + + + + D Sbjct: 125 RATGAYSHSQGIHGLRDAIASGIASRDGFPANADDIFLTDGASPGVHLMMQLLIRNEKDG 184 Query: 186 VIIPAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTE------KSRLLILC 239 +++P P + Y+ L V S + L+ D++ +L + R L++ Sbjct: 185 ILVPIPQYPLYSASIALHGGALVPYYLNESTGWGLETSDVKKQLEDARSRGINVRALVVI 244 Query: 240 SPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIY-APATHTSFASLPDMY--- 295 +P NPTG V + +I + K+ L++L+DE+Y+ IY SF + Sbjct: 245 NPGNPTGQVLAEENQYDIVKFC-KNEGLVLLADEVYQENIYVDNKKFHSFKKIVRSLGYG 303 Query: 296 ERTLTVNGF---SK-AFAMTGWRLGYLAG---PKHIVAACSKLQGQVSSGASSIAQKAGV 348 E L + + SK + G R GY + K+ V+ ++ Q Sbjct: 304 EEDLPLVSYQSVSKGYYGECGKRGGYFEITGFSAPVREQIYKIAS-VNLCSNITGQILAS 362 Query: 349 AALGLGKAGGETVAEMVKA-------YRERRDFLVKSLGDIKGVKISEPQGAFYLFIDFS 401 + KA E+ A R L + ++G+ +E +GA Y+F Sbjct: 363 LVMNPPKASDESYASYKAEKDGILASLARRAKALEHAFNKLEGITCNEAEGAMYVFPQIC 422 Query: 402 -AYYGSEAEGFGLINDSSSLALYFLDKFQVAMVPGDAFGD-DS--CIRISYATSLDVLQA 457 EA + AL L+ + +VPG FG R + D + A Sbjct: 423 LPQKAIEAAKAANKAPDAFYALRLLESTGIVVVPGSGFGQVPGTWHFRCTILPQEDKIPA 482 Query: 458 AVEKIRKALEPLRA 471 + + E + Sbjct: 483 VISRFTVFHEAFMS 496 >3EZS-A nrPDB Length = 376 Score = 206 bits (525), Expect = 1e-53, Method: Composition-based stats. Identities = 72/396 (18%), Positives = 140/396 (35%), Gaps = 41/396 (10%) Query: 79 LKPSKTMVITDLAATLVQSGVPVIRLAAGEPDFDTPKVVAEAGINAIREGFTRYTLNAGI 138 +P + L + + L GEP F+TPK + +A N Y +A Sbjct: 4 FEPYPFERLRALLKEITPKKRGL-DLGIGEPQFETPKFIQDALKNHTHS-LNIYPKSAFE 61 Query: 139 TELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQA--VLAVCSPGDEVIIPAPYWVSY 196 LR A K + ++++ + G+++ L + + P P++ Y Sbjct: 62 ESLRAAQRGFFKRRFKIELKENELISTLGSREVLFNFPSFVLFDYQNPTIAYPNPFYQIY 121 Query: 197 TEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEE 256 A+ A +++P N+F L K ++ L+IL SP+NPTG L Sbjct: 122 EGAAKFIKAKSLLMPLTKENDFTP---SLNEKELQEVDLVILNSPNNPTGRTLSLEELIS 178 Query: 257 IARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASL-----PDMYERTLTVNGFSKAFAMT 311 ++ KH ++++DE Y I Y S + ++ L ++ SK + Sbjct: 179 WVKLALKH-DFILINDECYSEI-YENTPPPSLLEACMLAGNEAFKNVLVIHSLSKRSSAP 236 Query: 312 GWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRER 371 G R G++AG ++ + + +++ QKA AA + Y Sbjct: 237 GLRSGFIAGDSRLLEKYKAFRAYLGYTSANAIQKASEAAWLDDRHAEFF----RNIYANN 292 Query: 372 RDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVA 431 K + +FY+++ + + A + Sbjct: 293 LKLARKIFKNTLIYPY-----SFYVYLPV--------------QNGENFAKTLYQNEGII 333 Query: 432 MVPGDAFGDD----SCIRISYATSLDVLQAAVEKIR 463 +P G + +R++ +L+ +E I Sbjct: 334 TLPALYLGRNRIGADYVRLALVYDTPLLEKPLEIIE 369 >3NRA-A nrPDB Length = 407 Score = 206 bits (524), Expect = 2e-53, Method: Composition-based stats. Identities = 92/393 (23%), Positives = 161/393 (40%), Gaps = 25/393 (6%) Query: 89 DLAATLVQSGVPVIRLAAGEPD-FDTPKVVAEAGINAIREG-FTRYTLNAGITELREAIC 146 L G PV + G+ D + + ++ G YT G +R+ + Sbjct: 30 ALIRGAPIEGRPV-DFSHGDVDAHEPTPGAFDLFSAGVQSGGVQAYTEYRGDLGIRDLLA 88 Query: 147 RKLKEENGLSYAP-DQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADA 205 +L G D ++++ G + +L AV A + GD+V I P + + + + Sbjct: 89 PRLAAFTGAPVDARDGLIITPGTQGALFLAVAATVARGDKVAIVQPDYFANRKLVEFFEG 148 Query: 206 TPVVIPTKI----SNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARII 261 V + LD LE +R+ + +P+NP G VY + +IA + Sbjct: 149 EMVPVQLDYVSADETRAGLDLTGLEEAFKAGARVFLFSNPNNPAGVVYSAEEIGQIAALA 208 Query: 262 AKHPRLLVLSDEIYEHIIYAPATHTSF-ASLPDMYERTLTVNGFSKAFAMTGWRLGYLAG 320 A++ V++D++Y + YA A++T A E +T+ G SK +++G+RLG G Sbjct: 209 ARY-GATVIADQLYSRLRYAGASYTHLRAEAAVDAENVVTIMGPSKTESLSGYRLGVAFG 267 Query: 321 PKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLG 380 + I+A KLQ VS A+ +Q V +A G + + + ++ RD L+ L Sbjct: 268 SRAIIARMEKLQAIVSLRAAGYSQ--AVLRGWFDEAPG-WMEDRIARHQAIRDELLHVLR 324 Query: 381 DIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVAMVPGDAFGD 440 +GV PQ YLF + A + V + PG F Sbjct: 325 GCEGVFARTPQAGSYLFPRLPKLAVAPA----------EFVKILRLQAGVVVTPGTEFSP 374 Query: 441 D--SCIRISYATSLDVLQAAVEKIRKALEPLRA 471 +R++++ + AA +I +E RA Sbjct: 375 HTADSVRLNFSQDHEAAVAAARRIVTLVERYRA 407 >4GDY-A nrPDB Length = 439 Score = 200 bits (508), Expect = 1e-51, Method: Composition-based stats. Identities = 90/428 (21%), Positives = 175/428 (40%), Gaps = 58/428 (13%) Query: 80 KPSKTMVITDLAATLVQSGVPVIRLAAGEPD-----FDTPKVVAEAGI-----NAIREGF 129 PS +TD+ + +S +I LA G P+ F T + E G + + Sbjct: 15 NPSPIRTMTDILSRGPKS---MISLAGGLPNPNMFPFKTAVITVENGKTIQFGEEMMKRA 71 Query: 130 TRYTLNAGITELREAICR---KLKEENGLSYAPDQ----ILVSNGAKQSLLQAVLAVCSP 182 +Y+ +AGI EL + + KL + Y P Q + V++G++Q L + + +P Sbjct: 72 LQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINP 131 Query: 183 GDEVIIPAPYW--------VSYTEQARLADATPVVIPTKISNNF-LLDPKDLESKLTEKS 233 GD V++ P + +A ++P + + P+D ++ Sbjct: 132 GDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTP 191 Query: 234 RLLI-LCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLP 292 + L + + +NPTG+ +EI + K+ L++ D+ Y + + +F S+ Sbjct: 192 KFLYTVPNGNNPTGNSLTSERKKEIYELARKY-DFLIIEDDPYYFLQFNSGRVPTFLSM- 249 Query: 293 DMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAAL- 351 D+ R + + FSK + +G R+G+L GPK ++ + S+ Q L Sbjct: 250 DVDGRVIRADSFSKIIS-SGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLH 308 Query: 352 -GLGKAGGETVAEMVKAYRERRDFLV----KSLGDIKGVKISEPQGAFYLFIDFSAYYGS 406 + V ++ Y ++D ++ K L + + P +L+I Sbjct: 309 EWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHV--PAAGMFLWIKVKG---- 362 Query: 407 EAEGFGLINDSSSLALYFLDKFQVAMVPGDAFGDDS-----CIRISYATSL-DVLQAAVE 460 IND L K V M+PG+AF DS +R S++++ + + A + Sbjct: 363 -------INDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQ 415 Query: 461 KIRKALEP 468 + + ++ Sbjct: 416 VLAQLIKE 423 >1VP4-A nrPDB Length = 425 Score = 198 bits (502), Expect = 6e-51, Method: Composition-based stats. Identities = 84/424 (19%), Positives = 169/424 (39%), Gaps = 48/424 (11%) Query: 67 SVDMSLSPRVQSLKPSKTMVITDLAATLVQSGVPVIRLAAGEPDFDT-P-KVVAEAGINA 124 +++ +S Q++K S I AA I G PD +T P K +AE Sbjct: 16 NLEGKISKIGQNMKSSIIREILKFAA-----DKDAISFGGGVPDPETFPRKELAEIAKEI 70 Query: 125 IREGFT---RYTLNAGITELREAICRKLKEENGLS-YAPDQILVSNGAKQSLLQAVLAVC 180 I + + +Y+ G L++ I + L+ G++ D ++ + G++Q+L Sbjct: 71 IEKEYHYTLQYSTTEGDPVLKQQILKLLERMYGITGLDEDNLIFTVGSQQALDLIGKLFL 130 Query: 181 SPGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSR------ 234 ++ P ++ R A VV+P + +D LE KL+E + Sbjct: 131 DDESYCVLDDPAYLGAINAFRQYLANFVVVPLEDD---GMDLNVLERKLSEFDKNGKIKQ 187 Query: 235 ---LLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASL 291 + ++ + NP G + + I K+ L ++ D+ Y + Y T + Sbjct: 188 VKFIYVVSNFHNPAGVTTSLEKRKALVEIAEKY-DLFIVEDDPYGALRYEGETVDPIFKI 246 Query: 292 PDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAAL 351 ER + +N FSK A G R+G +AG K + + + + +I + L Sbjct: 247 GGP-ERVVLLNTFSKVLA-PGLRIGMVAGSKEFIRKIVQAKQSADLCSPAITHRLAARYL 304 Query: 352 GLGKAGGETVAEMVKAYRERRDFLVKSLGD----IKGVKISEPQGAFYLFIDFSAYYGSE 407 E + ++ YR +R ++ +L + I GVK + +G ++++ + Sbjct: 305 ERYDL-LEQLKPTIELYRRKRTVMLNALEEYFSDIPGVKWVKSEGGLFIWLTLPEGF--- 360 Query: 408 AEGFGLINDSSSLALYFLDKFQVAMVPGDAF----GDDSCIRISYA-TSLDVLQAAVEKI 462 D+ + Y + +V VPG F +R+S+ + + ++++ Sbjct: 361 --------DTWEMFEY-AKRKKVFYVPGRVFKVYDEPSPSMRLSFCLPPDEKIVEGIKRL 411 Query: 463 RKAL 466 R+ + Sbjct: 412 REVV 415 >4R2N-A nrPDB Length = 367 Score = 194 bits (492), Expect = 8e-50, Method: Composition-based stats. Identities = 83/365 (22%), Positives = 141/365 (38%), Gaps = 40/365 (10%) Query: 100 PVIRLAAGEPDFDTPKVVAEAGINAIREGFTRYTLNAGITELREAICRKLKEENGLSYAP 159 I+LA+ E F P A I+ + RY N G +L+ A+ R L G +AP Sbjct: 24 GAIKLASNETVFG-PLPSVRAAIDRATDTVNRYPDN-GCVQLKAALARHL----GPDFAP 77 Query: 160 DQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNNFL 219 + + V G+ Q V S GDEV+ + Y Q R+A A P+ +P + Sbjct: 78 EHVAVGCGSVSLCQQLVQVTASVGDEVVFGWRSFELYPPQVRVAGAIPIQVPLT---DHT 134 Query: 220 LDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHII 279 D + + +T+++RL+ +C+P+NPT +V L + H +L+ DE Y I Sbjct: 135 FDLYAMLATVTDRTRLIFVCNPNNPTSTVVGPDALARFVEAVPAH--ILIAIDEAYVEYI 192 Query: 280 YAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGA 339 S L + + + FSKA+ + G R+GY G ++ A K+ V Sbjct: 193 RDGMRPDSL-GLVRAHNNVVVLRTFSKAYGLAGLRIGYAIGHPDVITALDKV--YVPFTV 249 Query: 340 SSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLGDIKGVKISEPQGAFYLFID 399 SSI Q A + + R + L G + Q F +++ Sbjct: 250 SSIGQAAA----IASLDAADELLARTDTVVAERARVSAELRAA-GFTLPPSQANF-VWLP 303 Query: 400 FSAYYGSEAEGFGLINDSSSLALYFLDKFQVAMVPGDAFGDDSCIRISYATSLDVLQAAV 459 + E ++ + P +G D +R++ A + A Sbjct: 304 LGSRTQDFVEQAA--------------DARIVVRP---YGTDG-VRVTVAAPEEN--DAF 343 Query: 460 EKIRK 464 + + Sbjct: 344 LRFAR 348 >1IJI-A nrPDB Length = 356 Score = 193 bits (490), Expect = 2e-49, Method: Composition-based stats. Identities = 89/391 (22%), Positives = 153/391 (39%), Gaps = 43/391 (10%) Query: 84 TMVITDLAATLVQSGVPV--IRLAAGEPDFDTPKVVAEAGINAIREGFTRYTLNAGITEL 141 T+ ITDLA V++ P R G D + A A+ T+ TLN Sbjct: 3 TVTITDLARENVRNLTPYQSARRLGGNGDV---WLNANEYPTAVEFQLTQQTLNRYPECQ 59 Query: 142 REAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPG-DEVIIPAPYWVSYTEQA 200 +A+ + G+ P+Q+LVS GA + + + A C PG D ++ P + Y+ A Sbjct: 60 PKAVIENYAQYAGVK--PEQVLVSRGADEGIELLIRAFCEPGKDAILYCPPTYGMYSVSA 117 Query: 201 RLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARI 260 +PT +N+ LD + + KL + +++ +CSP+NPTG + + + Sbjct: 118 ETIGVECRTVPTL--DNWQLDLQGISDKL-DGVKVVYVCSPNNPTGQLINPQDFRTLLEL 174 Query: 261 IAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYLAG 320 + +V++DE Y S A Y + SKAFA+ G R G+ Sbjct: 175 TR--GKAIVVADEAYIEF----CPQASLAGWLAEYPHLAILRTLSKAFALAGLRCGFTLA 228 Query: 321 PKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLG 380 + ++ K+ A +AA L G + E V R++L+ +L Sbjct: 229 NEEVINLLMKVIAPYPLSTPV----ADIAAQALSPQGIVAMRERVAQIIAEREYLIAALK 284 Query: 381 DIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVAMVPGDAFGD 440 +I V+ Y+ F A SS++ D+ + Sbjct: 285 EIPCVEQVFDSETNYILARFKA--------------SSAVFKSLWDQGIILRDQNKQPSL 330 Query: 441 DSCIRISYATSLDVLQAAVEKIRKALEPLRA 471 C+RI+ T + ++ ++ LRA Sbjct: 331 SGCLRITVGTREES--------QRVIDALRA 353 >3CQ5-A nrPDB Length = 369 Score = 191 bits (484), Expect = 7e-49, Method: Composition-based stats. Identities = 79/370 (21%), Positives = 141/370 (38%), Gaps = 44/370 (11%) Query: 102 IRLAAGEPDFDTPKVVAE---AGINAIREGFTRYTLNAGITELREAICRKLKEENGLSYA 158 IRL E + + + A ++ I RY + ELR+ + + ++ G++ Sbjct: 33 IRLNTNENPYPPSEALVADLVATVDKIATELNRYPERDAV-ELRDELAAYITKQTGVAVT 91 Query: 159 PDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADATPV-VIPTKISNN 217 D + +NG+ + L Q + A PG + P SY+ LA T I + Sbjct: 92 RDNLWAANGSNEILQQLLQAFGGPGRTALGFQP---SYSMHPILAKGTHTEFIAVSRGAD 148 Query: 218 FLLDPK-DLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYE 276 F +D LE ++ ++ + +P+NPTG V +E I + +V+ DE Y Sbjct: 149 FRIDMDVALEEIRAKQPDIVFVTTPNNPTGDVTSLDDVERIINVAPG----IVIVDEAYA 204 Query: 277 HIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVS 336 +P+ T P + + SKAF G RLGY + A ++ + Sbjct: 205 EFSPSPSATTLLEKYPT---KLVVSRTMSKAFDFAGGRLGYFVANPAFIDAVMLVR--LP 259 Query: 337 SGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLGDIKGVKISEPQGAFYL 396 S+++Q A + AL + +T+ + K ER + L ++ G + + F Sbjct: 260 YHLSALSQAAAIVAL---RHSADTLGTVEKLSVERV-RVAARLEEL-GYAVVPSESNFVF 314 Query: 397 FIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVAMVPGDAFGDDSCIRISYATSLDV-- 454 F DFS + + + +A +R + + Sbjct: 315 FGDFSDQHAAWQAFLDRG--------VLIRDVGIA----------GHLRTTIGVPEENDA 356 Query: 455 -LQAAVEKIR 463 L AA E I+ Sbjct: 357 FLDAAAEIIK 366 >3GET-A nrPDB Length = 365 Score = 187 bits (475), Expect = 8e-48, Method: Composition-based stats. Identities = 79/369 (21%), Positives = 143/369 (38%), Gaps = 37/369 (10%) Query: 89 DLAATLVQSGVP-VIRLAAGEPDFDTPKVVAEAGINAIREGFTRYTLNAGITELREAICR 147 D+ + GV VI+LA+ E F TP E + + + EL+ + + Sbjct: 19 DIEVIAKEYGVKEVIKLASNENPFGTPPKAIECLRQNANKAHLY--PDDSMIELKSTLAQ 76 Query: 148 KLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADATP 207 K K +N + I++ G+ Q + A+ + + + + + Y A+ A Sbjct: 77 KYKVQN------ENIIIGAGSDQVIEFAIHSKLNSKNAFLQAGVTFAMYEIYAKQCGAKC 130 Query: 208 VVIPTKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRL 267 T+ + L + K L ++ +L+ LC P+NP G S E + + + Sbjct: 131 --YKTQSITHNLDEFKKLYETHKDEIKLIFLCLPNNPLGECLDASEATEFIKGVNE--DC 186 Query: 268 LVLSDEIYEHIIY--APATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIV 325 LV+ D Y H L ++ L + FSK + + G R+GY +I+ Sbjct: 187 LVVIDAAYNEFASFKDSKKHLEPCELIKEFDNVLYLGTFSKLYGLGGLRIGYGIANANII 246 Query: 326 AACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLGDIKGV 385 +A KL+ S++A KA VAA+ + +T+ L K + Sbjct: 247 SAFYKLRAPF--NVSNLALKAAVAAMDDDEFTEKTLENNFSQME-----LYKEFAKKHNI 299 Query: 386 KISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVAMVPGDAFGDDSCIR 445 KI + F + F +S+ L+ L K + + ++G + IR Sbjct: 300 KIIDSYTNFITY-------------FFDEKNSTDLSEKLLKK-GIIIRNLKSYGL-NAIR 344 Query: 446 ISYATSLDV 454 I+ TS + Sbjct: 345 ITIGTSYEN 353 >6HNB-A nrPDB Length = 491 Score = 179 bits (454), Expect = 3e-45, Method: Composition-based stats. Identities = 84/426 (19%), Positives = 146/426 (34%), Gaps = 70/426 (16%) Query: 105 AAGEPDFDTPKVVAEAGINAIREGFTR--------YTLNAGITELREAICRKLKEENGLS 156 G P K E A + Y G+ E + I + + Sbjct: 70 GIGAPIEGENKTTIEVFKKAADNVPDQIELARSLQYGSTFGLPEFLQFIKEHTDMVHKVP 129 Query: 157 YAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKISN 216 Y ++VS G ++ + CS GD +++ + S E A +P + Sbjct: 130 YENWDVIVSVGNTEAWDSTLRTFCSKGDTILVEEYTFSSALESAN--GQGVNTVPVTMDE 187 Query: 217 NFLLDPKDLESKLT----EKSRLLI-LCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLS 271 F + P+ LE ++ K + L +C+ NPTGS ++I I K+ L++ Sbjct: 188 -FGIIPEKLEELMSRWVGNKPKFLYTICTGQNPTGSSLSAERRKQIYDIACKY-DFLIIE 245 Query: 272 DEIYEHI---------------------IYAPATHTSFASLPDMYERTLTVNGFSKAFAM 310 DE Y + + A SF SL D+ R + ++ FSK A Sbjct: 246 DEPYYFLQMETYTKDKAAREGKAVHDHDEFLKALVPSFISL-DVEGRVVRLDSFSKVLA- 303 Query: 311 TGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGG--ETVAEMVKAY 368 G RLG++ G K ++ +L S ++ A L G + + + Y Sbjct: 304 PGLRLGWIVGQKDLLERYVRLHEVSVQNPSGFSEALANALLRKWGHSGYLDWLIGLRAEY 363 Query: 369 RERRDFLVKSLGDIKGVKI---SEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFL 425 +RD + +L ++ + P + + A + + F + D + Sbjct: 364 THKRDVAIDALDQFVPKEVSSFNPPVAGMFFTVTLDASKHPKYKEF--LEDPLKVEAAVH 421 Query: 426 D---KFQVAMVPGDAFGDDS-------------------CIRISY-ATSLDVLQAAVEKI 462 + K + PG F + R +Y A LD L +EK Sbjct: 422 EQAIKQGCLLAPGSWFKAEGQSSPPQKNLPANPSHKTHIFFRGTYAAVPLDQLVVGLEKF 481 Query: 463 RKALEP 468 KA+ Sbjct: 482 GKAVRA 487 >3FKD-A nrPDB Length = 350 Score = 176 bits (445), Expect = 2e-44, Method: Composition-based stats. Identities = 66/357 (18%), Positives = 126/357 (35%), Gaps = 51/357 (14%) Query: 118 AEAGINAIREGFT---RYT-LNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLL 173 + + E Y +AG LR+ + ++ +N + ILV+NG + Sbjct: 30 KDHLEKHLVENLNCIRHYPEPDAGT--LRQMLAKRNSVDN------NAILVTNGPTAAFY 81 Query: 174 QAVLAVCSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKS 233 Q A G +I P + Y + R+ + P+ +D+ Sbjct: 82 QIAQAF--RGSRSLIAIPSFAEYEDACRMYEHEVCFYPSN---------EDIGEADFSNM 130 Query: 234 RLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPD 293 LC+P+NP G + ++ EI R++ HP + D+ Y + Sbjct: 131 DFCWLCNPNNPDGRLLQRT---EILRLLNDHPDTTFVLDQSYVSFTTEEVIRPA---DIK 184 Query: 294 MYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGL 353 + + V FS A+ + G R+GY+ K + + + A A AA + Sbjct: 185 GRKNLVMVYSFSHAYGIPGLRIGYIVANKDFMKRVAAFSTPWAVNA-----LAIEAAKFI 239 Query: 354 GKAGGETVAEMVKAYRERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGL 413 + + K R DF + +L + GV++ P G + + + Sbjct: 240 LIHPAQFTLPIRKWQRNTVDF-ITALNRLDGVEV-HPSGTTFFLLRLKKGTAA------- 290 Query: 414 INDSSSLALYFLDKFQVAMVPGDAFGD--DSCIRISYATSLDVLQAAVEKIRKALEP 468 L Y L+++ + + F +S +RI+ Q ++ + LE Sbjct: 291 -----ELKKYMLEEYNMLIRDASNFRGLDESYVRITTQRPAQN-QLFIKALETFLEK 341 >4RAE-A nrPDB Length = 394 Score = 173 bits (439), Expect = 1e-43, Method: Composition-based stats. Identities = 84/383 (21%), Positives = 148/383 (38%), Gaps = 44/383 (11%) Query: 94 LVQSGVPVIRLAAGEPDFDTPKVVAEAGINAIREG---FTRYTLNAGITELREAICRKLK 150 Q VPV RL E + + + + ++RE RY + LR + L Sbjct: 28 APQLAVPV-RLNTNENPHPPTRALVDDVVRSVREAAIDLHRYPDRDAV-ALRADLAGYLT 85 Query: 151 EENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADATPVV- 209 + G+ + I +NG+ + L Q + A PG I P SY+ ++D T Sbjct: 86 AQTGIQLGVENIWAANGSNEILQQLLQAFGGPGRSAIGFVP---SYSMHPIISDGTHTEW 142 Query: 210 IPTKISNNFLL-DPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLL 268 I +N+F L + + + K ++ + SP+NP+G L ++ + + Sbjct: 143 IEASRANDFGLDVDVAVAAVVDRKPDVVFIASPNNPSGQSVSLPDLCKLLDVAPG----I 198 Query: 269 VLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAAC 328 + DE Y P+ + P + + SKAFA G RLGYL ++ A Sbjct: 199 AIVDEAYGEFSSQPSAVSLVEEYP---SKLVVTRTMSKAFAFAGGRLGYLIATPAVIDAM 255 Query: 329 SKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLGDIKGVKIS 388 L ++ SS+ Q A AAL +VA ++ R+ + SL D+ G ++ Sbjct: 256 --LLVRLPYHLSSVTQAAARAALRHSDDTLSSVAALIAE----RERVTTSLNDM-GFRVI 308 Query: 389 EPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVAMVPGDAFGDDSCIRISY 448 F LF +F+ D+ + +L+ + + G +R + Sbjct: 309 PSDANFVLFGEFA--------------DAPAAWRRYLE-AGILIRDV---GIPGYLRATT 350 Query: 449 ATSLDV--LQAAVEKIRKALEPL 469 + + A +I L P+ Sbjct: 351 GLAEENDAFLRASARIATDLVPV 373 >3HDO-A nrPDB Length = 360 Score = 170 bits (430), Expect = 1e-42, Method: Composition-based stats. Identities = 77/369 (20%), Positives = 141/369 (38%), Gaps = 50/369 (13%) Query: 102 IRLAAGEPDFDTPKVVAEAGINAI--REGFTRYTLNAGITELREAICRKLKEENGLSYAP 159 I+L E + V +A + + R +A +LRE + P Sbjct: 29 IKLNTNENPYPPSPEVVKAILEELGPDGAALRIYPSASSQKLREVAGELY------GFDP 82 Query: 160 DQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNNFL 219 I+++NG+ + L + A + G+E+ P + Y A + A ++ +F Sbjct: 83 SWIIMANGSDEVLNNLIRAFAAEGEEIGYVHPSYSYYGTLAEVQGARVRTF--GLTGDFR 140 Query: 220 LD--PKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEH 277 + P+ E ++ L +P+ P G +P ++E+AR A +++ DE Y Sbjct: 141 IAGFPERYEG------KVFFLTTPNAPLGPSFPLEYIDELARRCAG----MLVLDETYAE 190 Query: 278 IIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSS 337 ++ L +E + SK++++ G R+G ++AA K++ Sbjct: 191 F-----AESNALELVRRHENVVVTRTLSKSYSLAGMRIGLAIARPEVIAALDKIRDH--Y 243 Query: 338 GASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLGDIKGVKISEPQGAFYLF 397 +AQ A VAAL ++E + RE R++ L I G + QG YLF Sbjct: 244 NLDRLAQAACVAAL----RDQAYLSECCRRIRETREWFTTELRSI-GYDVIPSQGN-YLF 297 Query: 398 IDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVAMVPGDAFGDDSCIRISYATSLDVLQ- 456 G L +V + +RIS T ++ Q Sbjct: 298 ATPPDRDGKRVYDG-------------LYARKVLVRHFSDPLLAHGMRISIGTREEMEQT 344 Query: 457 -AAVEKIRK 464 AA+++I + Sbjct: 345 LAALKEIGE 353 >2X5F-A nrPDB Length = 430 Score = 165 bits (417), Expect = 4e-41, Method: Composition-based stats. Identities = 76/364 (20%), Positives = 154/364 (42%), Gaps = 42/364 (11%) Query: 132 YTLNAGITELREAICRKLKEENGLSYAPDQI---LVSNGAKQSLLQAVLAVCSPGDEVII 188 Y GI ELR+ +K+ +N + D + +V+N L + D +++ Sbjct: 84 YAPPQGIEELRDLWQQKMLRDN-PELSIDNMSRPIVTNALTHGLSLVGDLFVNQDDTILL 142 Query: 189 PAPYWVSYTEQARL-ADATPVVIPT-KISNNFLLD--PKDLESKLTEKSRLLILCSPSNP 244 P W +Y A P ++ D + L+S +K ++IL P+NP Sbjct: 143 PEHNWGNYKLVFNTRNGANLQTYPIFDKDGHYTTDSLVEALQSYNKDKV-IMILNYPNNP 201 Query: 245 TGSVYPKSL----LEEIARIIAKHPRLLVLSDEIYEHIIYAPA-THTSFASLPDMYERTL 299 TG +E I + K +++ + D+ Y + Y T + F +L +++ + Sbjct: 202 TGYTPTHKEVTTIVEAIKALANKGTKVIAVVDDAYYGLFYEDVYTQSLFTALTNLHSNAI 261 Query: 300 T---VNGFSKAFAMTGWRLGYLA------GPKHIVAACSKLQGQVSSGASS---IAQKAG 347 ++G +K F G+R+G++ K ++ A K++G + S SS Q A Sbjct: 262 LPIRLDGATKEFFAWGFRVGFMTFGTSDQTTKEVLEA--KVKGLIRSNISSGPLPTQSAV 319 Query: 348 VAALGLGKAGGETVAEMVKAYRERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSE 407 L K + + + ++ +ER + K V ++ + + DF++ Y Sbjct: 320 KHVLKNNKQFDKEIEQNIQTLKERYEV-------TKEVVYADQYHSHWQAYDFNSGYFMA 372 Query: 408 AEGFGLINDSSSLALYFLDKFQVAMVPGDAFGDDSCIRISYAT-SLDVLQAAVEKIRKAL 466 + + D +L + +DK+ + ++ +A + IRI+++ D + + I KA+ Sbjct: 373 IKVHDV--DPEALRKHLIDKYSIGVIALNA----TDIRIAFSCVEKDDIPHVFDSIAKAI 426 Query: 467 EPLR 470 + LR Sbjct: 427 DDLR 430 >6HNV-A nrPDB Length = 524 Score = 165 bits (417), Expect = 5e-41, Method: Composition-based stats. Identities = 72/393 (18%), Positives = 138/393 (35%), Gaps = 65/393 (16%) Query: 131 RYTLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPA 190 +Y G L + + + +Y + ++ GA L +A GD +++ Sbjct: 129 QYAAVEGHAPLLQFARDFIIRTHKPNYDDWNVFITTGASDGLNKAADVFLDDGDVILVEE 188 Query: 191 PYWVSYTEQARLADATPVVIPTKISNN--------FLLDPKDLES--KLTEKSRLLI-LC 239 + + + A A V + N+ F+ ++ E K + L + Sbjct: 189 FTFSPFLRFSDNAGAKAVPVKINFDNDSDGIDLTQFVDLLENWEKHYPNLPKPKALYTIA 248 Query: 240 SPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHII-------------------- 279 + NPTG ++I + K+ ++ D+ Y ++ Sbjct: 249 TGQNPTGFTQSLEFRKKIYDLAVKY-DFAIIEDDPYGYLTLPKYEKPNIGGSGSGNNELK 307 Query: 280 -------YAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQ 332 Y T D R L V FSK FA G RLG++ G K ++ A Sbjct: 308 NDLEIDDYLKNHLTPSYLELDTTGRVLRVETFSKLFA-PGLRLGFIVGHKEVIDAVKNYS 366 Query: 333 GQVSSGASSIAQK----AGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLGDIKGVK-- 386 V+ GAS + Q E + +M Y R+D L+ S+ + + K Sbjct: 367 DVVNRGASGLTQTIVNNVIQENFKGVDGWLEWILKMRLNYSYRKDLLLYSIFESQAYKKG 426 Query: 387 ---ISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVAMVPGDA------ 437 + +P+ F+ F + + + L L+ L + + +VPG Sbjct: 427 YVDVIDPKAGM--FVTFKINLPKDVD----VLQKMKLLLWKLISYGILVVPGYNMTVDLE 480 Query: 438 FGDD--SCIRISY--ATSLDVLQAAVEKIRKAL 466 F D + R+ Y A + + + + +++ A+ Sbjct: 481 FSKDRSNFFRLCYALANNDEEILESGKRLTDAV 513 >3FFH-A nrPDB Length = 363 Score = 164 bits (414), Expect = 9e-41, Method: Composition-based stats. Identities = 69/367 (18%), Positives = 135/367 (36%), Gaps = 39/367 (10%) Query: 99 VPVIRLAAGEPDFDTPKVVAEAGINAIREGFTRYTLNAGITELREAICRKLKEENGLSYA 158 + +L++ E T K V A I A T + + LR+ + + Sbjct: 32 TKITKLSSNENPLGTSKKV--AAIQANSSVETEIYPDGWASSLRKEVADFYQ------LE 83 Query: 159 PDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNNF 218 ++++ + G + + + ++ P +V Y + A + A IP Sbjct: 84 EEELIFTAGVDELIELLTRVLLDTTTNTVMATPTFVQYRQNALIEGAEVREIPLLQDGEH 143 Query: 219 LLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHI 278 D + + + + EK+ ++ +C+P+NPTG+ + ++ + +LV+ DE Y Sbjct: 144 --DLEGMLNAIDEKTTIVWICNPNNPTGNYIELADIQAFLDRVPS--DVLVVLDEAYIEY 199 Query: 279 I-YAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSS 337 + P H L Y+ + FSK + + R+GY K I+ + ++ Sbjct: 200 VTPQPEKHE---KLVRTYKNLIITRTFSKIYGLASARVGYGIADKEIIRQLNIVRPPF-- 254 Query: 338 GASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLGDIKGVKISEPQGAFYLF 397 +SI QK + A+ GE ++ + K +K P ++ Sbjct: 255 NTTSIGQKLAIEAIKDQAFIGECRTSNANGIKQ-YEAFAKRFEKVKLY----PANGNFVL 309 Query: 398 IDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVAMVPGDAFGDDSCIRISYATSLDV--L 455 ID G+ L+K G A G + +RI+ D + Sbjct: 310 IDLGIEAGTIFSY--------------LEKNGYITRSGAALGFPTAVRITIGKEEDNSAV 355 Query: 456 QAAVEKI 462 A +EK+ Sbjct: 356 IALLEKL 362 >1UU1-A nrPDB Length = 335 Score = 160 bits (405), Expect = 1e-39, Method: Composition-based stats. Identities = 69/374 (18%), Positives = 134/374 (35%), Gaps = 52/374 (13%) Query: 82 SKTMVITDLAATLVQSGVPVIRLAAGEPDFDTPKVVAEAGINAIREGFTRYTLNAGITEL 141 + +I A LA E F P+ + + + R ++ EL Sbjct: 2 NPLDLIAKRAYPYETEKRDKTYLALNENPFPFPEDLVDEVFRRLNSDALRIYYDSPDEEL 61 Query: 142 REAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQAR 201 E I L + + + + V NGA + + +L D + P + Y A+ Sbjct: 62 IEKILSYLDTDF---LSKNNVSVGNGADEIIYVMMLMF----DRSVFFPPTYSCYRIFAK 114 Query: 202 LADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARII 261 A + +P + + ++ + +P+NPTG V+ + +E I + Sbjct: 115 AVGAKFLEVPLTKDLR-------IPEVNVGEGDVVFIPNPNNPTGHVFEREEIERILK-- 165 Query: 262 AKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYLAGP 321 V DE Y S+ YE + FSKAF++ R+GY+ Sbjct: 166 ---TGAFVALDEAYYEFHGE-----SYVDFLKKYENLAVIRTFSKAFSLAAQRVGYVVAS 217 Query: 322 KHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLGD 381 + + A ++++ + S ++Q AL E E K E R+ + +L + Sbjct: 218 EKFIDAYNRVR--LPFNVSYVSQMFAKVALDH----REIFEERTKFIVEERERMKSALRE 271 Query: 382 IKGVKISEPQGAF-YLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVAMVPGDAFGD 440 + G +I++ +G F ++F++ L VA+ +F + Sbjct: 272 M-GYRITDSRGNFVFVFMEKEEKERLLEH---------------LRTKNVAV---RSFRE 312 Query: 441 DSCIRISYATSLDV 454 +RI+ + Sbjct: 313 G--VRITIGKREEN 324 >3EUC-A nrPDB Length = 367 Score = 157 bits (396), Expect = 1e-38, Method: Composition-based stats. Identities = 80/394 (20%), Positives = 147/394 (37%), Gaps = 44/394 (11%) Query: 76 VQSLKPSKT-MVITDLAATLVQSGVP----VIRLAAGEPDFDTPKVVAEAGINAIRE-GF 129 + + PS +I D + VP +++L A E + P + + E Sbjct: 2 MSVVDPSLIERIIRDDVRAMGAYHVPDSHGLVKLDAMENPYRLPPALRSELAARLGEVAL 61 Query: 130 TRYTLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIP 189 RY LR + ++ G+ ++L+ NG+ + + LA PG +V+ P Sbjct: 62 NRY-PVPSSEALRAKLKEVMQVPAGM-----EVLLGNGSDEIISMLALAAARPGAKVMAP 115 Query: 190 APYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLL-ILCSPSNPTGSV 248 P +V Y A+ A V +P + +F LD + + + E + L P+NPTG++ Sbjct: 116 VPGFVMYAMSAQFAGLEFVGVPLRA--DFTLDRGAMLAAMAEHQPAIVYLAYPNNPTGNL 173 Query: 249 YPKSLLEEIARIIAKHP-RLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKA 307 + + +E I R R LV+ DE Y+ P S+ S + L + SK Sbjct: 174 FDAADMEAIVRAAQGSVCRSLVVVDEAYQ-----PFAQESWMSRLTDFGNLLVMRTVSK- 227 Query: 308 FAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKA 367 + G RLGY+AG + K++ + + + + AL + E Sbjct: 228 LGLAGIRLGYVAGDPQWLEQLDKVRP--PYNVNVLTEATALFALEHVAV----LDEQAAQ 281 Query: 368 YRERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDK 427 R R + + + GV + F L + + + + K Sbjct: 282 LRAERSRVAEGMAAHGGVTVFPSAANFLL--------------ARVPDAAQTFDRLLARK 327 Query: 428 FQVAMVPGDAFGDDSCIRISYATSLDV--LQAAV 459 + V +C+R++ +T + A Sbjct: 328 VLIKNVSKMHPLLANCLRVTVSTPEENAQFLEAF 361 >3LY1-A nrPDB Length = 354 Score = 156 bits (393), Expect = 3e-38, Method: Composition-based stats. Identities = 74/370 (20%), Positives = 139/370 (37%), Gaps = 40/370 (10%) Query: 102 IRLAAGEPDFDTPKVVAEAGINAIREGFTRYTLNAGITELREAICRKLKEENGLSYAPDQ 161 IR+ E A +A+ + RY N + + KL + + Sbjct: 19 IRINFNENPLGMSPKAQAAARDAVVKA-NRYAKNEIL-----MLGNKLAAHHQVEAPS-- 70 Query: 162 ILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNNFLLD 221 IL++ G+ + + A+ A S +++IP + A++A + K+ +N+ D Sbjct: 71 ILLTAGSSEGIRAAIEAYASLEAQLVIPELTYGDGEHFAKIAGMKVTKV--KMLDNWAFD 128 Query: 222 PKDLESKLT--EKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHII 279 + L++ + ++ L +P+NPTG++ P ++E I +K + + DE Y + Sbjct: 129 IEGLKAAVAAYSGPSIVYLVNPNNPTGTITPADVIEP--WIASKPANTMFIVDEAYAEFV 186 Query: 280 YAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGA 339 P + + E + + FSK AM G R+GY ++A + Sbjct: 187 NDPRFRSISPMITQGAENIILLKTFSKIHAMAGMRVGYAVAHPTVIALMGRYVAGEKINF 246 Query: 340 SSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLGDIKGVKISEPQGAFYLFID 399 S GV A + K+ R L+K+L D+K + +G F Sbjct: 247 S------GVDAALASMNDSAFITYSKKSNDVSRQILLKALEDLK-LPYLPSEGNFVF--- 296 Query: 400 FSAYYGSEAEGFGLINDSSSLALYFLDKFQVAMVPGDAF-GDDSCIRISYATSLDVLQAA 458 L+ + V + G AF D+ RIS T ++ Q Sbjct: 297 -----------HQLVVPLKDYQTHM-ADAGVLI--GRAFPPADNWCRISLGTPQEM-QWV 341 Query: 459 VEKIRKALEP 468 + +R+ + Sbjct: 342 ADTMREFRKK 351 >4JE5-A nrPDB Length = 503 Score = 155 bits (391), Expect = 5e-38, Method: Composition-based stats. Identities = 78/395 (19%), Positives = 129/395 (32%), Gaps = 65/395 (16%) Query: 131 RYTLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPA 190 +Y +AG EL I K + L Y +L + G + + C+ GD +++ A Sbjct: 107 QYGFSAGQPELLNFIRDHTKIIHDLKYKDWDVLATAGNTNAWESTLRVFCNRGDVILVEA 166 Query: 191 PYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKL------TEKSRLLI-LCSPSN 243 + S A +P + P+ L + K +LL + + N Sbjct: 167 HSFSSSLASAEAQGVITFPVPIDAD---GIIPEKLAKVMENWTPGAPKPKLLYTIPTGQN 223 Query: 244 PTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAP----------------ATHTS 287 PTG+ E I +I K+ L++ DE Y + P H Sbjct: 224 PTGTSIADHRKEAIYKIAQKY-DFLIVEDEPYYFLQMNPYIKDLKEREKAQSSPKQDHDE 282 Query: 288 FAS-------LPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGAS 340 F D R + ++ FSK A G RLG++ G I+ L + Sbjct: 283 FLKSLANTFLSLDTEGRVIRMDSFSKVLA-PGTRLGWITGSSKILKPYLSLHEMTIQAPA 341 Query: 341 SIAQKAGVAAL--GLGKAGGETVAEMVKAYRERR----DFLVKSLGDIKGVKISEPQGAF 394 Q A L K + + + Y +R D L K L I+ P Sbjct: 342 GFTQVLVNATLSRWGQKGYLDWLLGLRHEYTLKRDCAIDALYKYLPQSDAFVINPPIAGM 401 Query: 395 YLFIDFSAYYGSEAEGFGLINDSSSLALYFLD---KFQVAMVPGDAFGDDS--------- 442 + ++ A E + +D L + V +VPG F + Sbjct: 402 FFTVNIDASVHPEFK-TKYNSDPYQLEQSLYHKVVERGVLVVPGSWFKSEGETEPPQPAE 460 Query: 443 ----------CIRISY-ATSLDVLQAAVEKIRKAL 466 R +Y A S + L ++++ L Sbjct: 461 SKEVSNPNIIFFRGTYAAVSPEKLTEGLKRLGDTL 495 >5X03-B nrPDB Length = 365 Score = 152 bits (383), Expect = 4e-37, Method: Composition-based stats. Identities = 68/346 (19%), Positives = 144/346 (41%), Gaps = 27/346 (7%) Query: 133 TLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPY 192 + GI E+R AI R + G+ P+Q+++ G Q L+Q + + + P Sbjct: 39 SHPQGIYEVRAAITRLISLTRGVKCRPEQMIIGAG-TQVLMQLLTELLPKEAVYAMEEPG 97 Query: 193 WVSYTEQARLADATPVVIPTKISNNFLLDPKDLE-SKLTEKSRLLILCSPSN--PTGSVY 249 Y +L + T +LD K + +++T + +++ +PS+ P+G++ Sbjct: 98 ---YRRMYQLLKNAGKQVKT-----IMLDEKGMSIAEITRQQPDVLVTTPSHQFPSGTIM 149 Query: 250 PKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFA 309 P S ++ A+ PR ++ D+ Y + + SL D ++ + + FSK+ Sbjct: 150 PVSRRIQLLNWAAEEPRRYIIEDDYDSEFTYDVDSIPALQSL-DRFQNVIYMGTFSKSL- 207 Query: 310 MTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYR 369 + G R+ Y+ P ++ A K +G SS+ Q + G+ + + +M + Y+ Sbjct: 208 LPGLRISYMVLPPELLRAY-KQRGYDLQTCSSLTQLTLQEFIESGEY-QKHIKKMKQHYK 265 Query: 370 ERRDFLVKSLGDI--KGVKISEPQGAFYLFIDFSAYYGSEA---EGFGLINDSSSLALYF 424 E+R+ L+ +L V + + +F + GL + ++ + Sbjct: 266 EKRERLITALEAEFSGEVTVKGANAGLHFVTEFDTRRTEQDILSHAAGLQLEIFGMSRFN 325 Query: 425 LDKFQVAMVPGDAFGDDSCIRISYATSLDVLQAAVEKIRKALEPLR 470 L + + G R+ + +Q V+++ KA+ R Sbjct: 326 LKENKRQT--GRPALIIGFARL----KEEDIQEGVQRLFKAVYGHR 365 >4N0B-A nrPDB Length = 479 Score = 152 bits (383), Expect = 4e-37, Method: Composition-based stats. Identities = 67/342 (19%), Positives = 143/342 (41%), Gaps = 27/342 (7%) Query: 133 TLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPY 192 + GI E+R AI R + G+ P+Q+++ G Q L+Q + + + P Sbjct: 146 SHPQGIYEVRAAITRLISLTRGVKCRPEQMIIGAG-TQVLMQLLTELLPKEAVYAMEEPG 204 Query: 193 WVSYTEQARLADATPVVIPTKISNNFLLDPKDLE-SKLTEKSRLLILCSPSN--PTGSVY 249 Y +L + T +LD K + +++T + +++ +PS+ P+G++ Sbjct: 205 ---YRRMYQLLKNAGKQVKT-----IMLDEKGMSIAEITRQQPDVLVTTPSHQFPSGTIM 256 Query: 250 PKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFA 309 P S ++ A+ PR ++ D+ Y + + SL D ++ + + FSK+ Sbjct: 257 PVSRRIQLLNWAAEEPRRYIIEDDYDSEFTYDVDSIPALQSL-DRFQNVIYMGTFSKSL- 314 Query: 310 MTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYR 369 + G R+ Y+ P ++ A K +G SS+ Q + G+ + + +M + Y+ Sbjct: 315 LPGLRISYMVLPPELLRAY-KQRGYDLQTCSSLTQLTLQEFIESGEY-QKHIKKMKQHYK 372 Query: 370 ERRDFLVKSLGDI--KGVKISEPQGAFYLFIDFSAYYGSEA---EGFGLINDSSSLALYF 424 E+R+ L+ +L V + + +F + GL + ++ + Sbjct: 373 EKRERLITALEAEFSGEVTVKGANAGLHFVTEFDTRRTEQDILSHAAGLQLEIFGMSRFN 432 Query: 425 LDKFQVAMVPGDAFGDDSCIRISYATSLDVLQAAVEKIRKAL 466 L + + G R+ + +Q V+++ KA+ Sbjct: 433 LKENKRQT--GRPALIIGFARL----KEEDIQEGVQRLFKAV 468 >2ZY3-A nrPDB Length = 546 Score = 151 bits (381), Expect = 7e-37, Method: Composition-based stats. Identities = 91/417 (21%), Positives = 151/417 (36%), Gaps = 72/417 (17%) Query: 122 INAIREGFTR-----YTLNAGITELREAI-CRKLKEENGLSYAPD---QILVSNGAKQSL 172 + E Y + + + E I + + E G P + G ++ Sbjct: 119 AAFLHEMVDGILGCNYPVPPRMLNISEKIVRQYIIREMGADAIPSESVNLFAVEGGTAAM 178 Query: 173 -----LQAVLAVCSPGDEVIIPAPYWVSYTEQARLADA--TPVVIPTKISNNFLLDPKDL 225 + + GD+V I P + Y E LA V I S N+ +L Sbjct: 179 AYIFESLKLNGLLKAGDKVAIGMPVFTPYIEIPELAQYALEEVAINADPSLNWQYPDSEL 238 Query: 226 ESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKH-PRLLVLSDEIYEHIIYAPAT 284 + ++ +PSNP + LE + I+A+H P L++L+D++Y +A Sbjct: 239 DKLKDPAIKIFFCVNPSNPPSVKMDQRSLERVRNIVAEHRPDLMILTDDVYG--TFADDF 296 Query: 285 HTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIV--AACSKLQG--------- 333 + FA P E TL V FSK F TGWRLG +A + V A KLQ Sbjct: 297 QSLFAICP---ENTLLVYSFSKYFGATGWRLGVVAAHQQNVFDLALDKLQESEKVALDHR 353 Query: 334 --------------------------QVSSGASSIAQ-KAGVAALGLGKAGGETVAEMVK 366 ++G S+ Q + + +L + +K Sbjct: 354 YRSLLPDVRSLKFIDRLVADSRAVALNHTAGLSTPQQVQMALFSLFALMDEADEYKHTLK 413 Query: 367 AYRERRDFLVKSLGDIKGVKISEPQGA--FYLFIDF----SAYYGSEAEGFGLINDSS-S 419 RR+ +L G+ + A +Y ID + YG + + S+ Sbjct: 414 QLIRRRE---TTLYRELGMPPLRDENAVDYYTLIDLQDVTAKLYGEAFSEWAVKQSSTGD 470 Query: 420 LALYFLDKFQVAMVPGDAFGDD-SCIRISYATSLDVLQAAVEK-IRKALEPLRATVS 474 + D+ + ++PG FG + R S A + AA+ + +RK + L A S Sbjct: 471 MLFRIADETGIVLLPGRGFGSNRPSGRASLANLNEYEYAAIGRALRKMADELYAEYS 527 >3F6T-A nrPDB Length = 533 Score = 150 bits (379), Expect = 1e-36, Method: Composition-based stats. Identities = 70/372 (18%), Positives = 137/372 (36%), Gaps = 69/372 (18%) Query: 161 QILVSNGAKQSLLQAVLAVCS-----PGDEVIIPAPYWVSYTEQARLADATPVVIPT--K 213 + + G +++ A ++ GD++ I P + Y L D V + Sbjct: 166 DLFPTEGGTAAIVYAFHSLAENHLLKKGDKIAINEPIFTPYLRIPELKDYELVEVDLHSY 225 Query: 214 ISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDE 273 N++ ++P ++E + LI+ +P+NPT + + L I + + K+P+L+++SDE Sbjct: 226 EKNDWEIEPNEIEKLKDPSIKALIVVNPTNPTSKEFDTNALNAIKQAVEKNPKLMIISDE 285 Query: 274 IYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPK-----HIVAAC 328 +Y + P + ++ +P T+ V +SK F TGWRLG +A + +A Sbjct: 286 VYGAFV--PNFKSIYSVVP---YNTMLVYSYSKLFGCTGWRLGVIALNEKNVFDDNIAHL 340 Query: 329 SKLQ--------------------------------GQVSSGASSIAQKA-------GVA 349 K++ ++G S+ Q + Sbjct: 341 DKVELRQLHKRYSSVVLDPDKMKFIDRLCADSRSIGLYHTAGLSTPQQIMEALFSMTHLL 400 Query: 350 ALGLGKAGGETVAEMVKAYRERRDFLVKSLGDIKGVKISEPQGAFYLFIDF-----SAYY 404 G + + K ER D L ++ K ++ +Y ID Y Sbjct: 401 TSTNGGSDDPYIDIARKLVSERYDQLHDAMQAPK--DETDTNTHYYSLIDIYRLAEKIYG 458 Query: 405 GSEAEGFGLINDSSSLALYFLDKFQVAMVPGDAFGD-DSCIRISYAT-SLDVL----QAA 458 + + L +K V +V G FG +R+S A + + Sbjct: 459 KEFRDYLTNNFEQVDFLLKLAEKNGVVLVDGVGFGAKPGELRVSQANLPTEDYALIGKQV 518 Query: 459 VEKIRKALEPLR 470 +E +++ E + Sbjct: 519 LELLKEYYEEFK 530 >3FTB-A nrPDB Length = 361 Score = 149 bits (376), Expect = 2e-36, Method: Composition-based stats. Identities = 63/310 (20%), Positives = 122/310 (39%), Gaps = 26/310 (8%) Query: 89 DLAATLVQSGVPVIRLAAGEPDFDTPKVVAEAGINAIREGFTRYTLNAGITELREAICRK 148 D+ V G ++ ++ PK I+ + Y L ++I Sbjct: 16 DIYTEGVFKGRELLDYSSNINPLGIPKSFLNN-IDEGIKNLGVYPDVN-YRRLNKSI--- 70 Query: 149 LKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADATPV 208 EN L I++ NGA + + ++ ++++I P + Y A+ + V Sbjct: 71 ---ENYLKLKDIGIVLGNGASEIIELSISLF----EKILIIVPSYAEYEINAKKHGVSVV 123 Query: 209 VIPTKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLL 268 + + N +D +D+ SK+ + +I+ +P+NP G + K + ++ + + + Sbjct: 124 F--SYLDENMCIDYEDIISKIDD-VDSVIIGNPNNPNGGLINKEKFIHVLKLAEEKKKTI 180 Query: 269 VLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGY-LAGPKHIVAA 327 ++ DE + P+ +SF Y + +K FAM G R GY + K I A Sbjct: 181 II-DEAFIEFTGDPS--SSFVGEIKNYSCLFIIRAMTKFFAMPGIRFGYGITNNKEIAAK 237 Query: 328 CSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLGDIKGVK- 386 Q +I A +AA+ K + E + ++ R ++ L I +K Sbjct: 238 IKAKQ-----NPWNINCFAEMAAINCLKDT-NYIEESLLWIKKERKRFIEELNKIGFIKR 291 Query: 387 ISEPQGAFYL 396 + P F L Sbjct: 292 VFSPHANFVL 301 >3FDD-A nrPDB Length = 533 Score = 149 bits (376), Expect = 2e-36, Method: Composition-based stats. Identities = 88/414 (21%), Positives = 145/414 (35%), Gaps = 72/414 (17%) Query: 122 INAIREGFTR-----YTLNAGITELREAI-CRKLKEENGLSYAPD---QILVSNGAKQSL 172 + E Y + + + E I + + E G P + G ++ Sbjct: 119 AAFLHEMVDGILGCNYPVPPRMLNISEKIVRQYIIREMGADAIPSESVNLFAVEGGTAAM 178 Query: 173 -----LQAVLAVCSPGDEVIIPAPYWVSYTEQARLADA--TPVVIPTKISNNFLLDPKDL 225 V + GD+V I P + Y E LA V I + N+ +L Sbjct: 179 AYIFESMKVNGLLKAGDKVAIGMPVFTPYIEIPELAQYALEEVAINADPALNWQYPDSEL 238 Query: 226 ESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKH-PRLLVLSDEIYEHIIYAPAT 284 + ++ +PSNP + LE + +I+A+H P L++L+D++Y +A Sbjct: 239 DKLKDPAIKIFFCVNPSNPPSVKMDERSLERVRKIVAEHRPDLMILTDDVYG--TFADGF 296 Query: 285 HTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKH--------------------- 323 + FA P TL V FSK F TGWRLG +A K Sbjct: 297 QSLFAICPA---NTLLVYSFSKYFGATGWRLGVVAAHKENIFDLALGRLPESEKTALDDR 353 Query: 324 ----------------IVAACSKLQGQVSSGASSIAQKAGVAA-LGLGKAGGETVAEMVK 366 +VA + ++G S+ Q L + +K Sbjct: 354 YRSLLPDVRSLKFLDRLVADSRAVALNHTAGLSTPQQVQMTLFSLFALMDESDQYKHTLK 413 Query: 367 AYRERRDFLVKSLGDIKGVKISEPQGA--FYLFIDF----SAYYGSEAEGFGLINDSS-S 419 RR+ +L G + A +Y ID S YG + + S+ Sbjct: 414 QLIRRRE---ATLYRELGTPPQRDENAVDYYTLIDLQDVTSKLYGEAFSKWAVKQSSTGD 470 Query: 420 LALYFLDKFQVAMVPGDAFGDD-SCIRISYATSLDVLQAAVEK-IRKALEPLRA 471 + D+ + ++PG FG D R S A + AA+ + +R+ + L A Sbjct: 471 MLFRIADETGIVLLPGRGFGSDRPSGRASLANLNEYEYAAIGRALRQMADELYA 524 >2ZY2-A nrPDB Length = 544 Score = 148 bits (373), Expect = 6e-36, Method: Composition-based stats. Identities = 80/410 (19%), Positives = 140/410 (34%), Gaps = 71/410 (17%) Query: 122 INAIREGFTR-----YTLNAGITELREAICRKLKEEN--GLSYAPD--QILVSNGAKQSL 172 + E Y + + + E I R+ G + P+ + G ++ Sbjct: 118 AAFLHEMVDGILGCNYPVPPRMLTVSEQIVRQYIVREMAGGAVPPESVDLFAVEGGTAAM 177 Query: 173 -----LQAVLAVCSPGDEVIIPAPYWVSYTEQARLA--DATPVVIPTKISNNFLLDPKDL 225 + + GD+V I P + Y E LA D V I N + +L Sbjct: 178 AYIFESLRISGLLKAGDKVAIGMPVFTPYIEIPELAQYDLKEVPIHADPDNGWQYSDAEL 237 Query: 226 ESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKH-PRLLVLSDEIYEHIIYAPAT 284 + ++ +PSNP + L+ + I+A+ P LL+L+D++Y +A Sbjct: 238 DKLKDPDVKIFFCVNPSNPPSVKMDQRSLDRVRAIVAEQRPDLLILTDDVYG--TFADEF 295 Query: 285 HTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKH--------------------- 323 + F+ P TL V FSK F TGWRLG +A K Sbjct: 296 QSLFSVCPR---NTLLVYSFSKYFGATGWRLGVIAAHKDNVFDHALSQLPESAKKALDHR 352 Query: 324 ----------------IVAACSKLQGQVSSGASSIAQKAGVAA-LGLGKAGGETVAEMVK 366 +VA + ++G S+ Q V L + + +K Sbjct: 353 YRSLLPDVRSLKFIDRLVADSRVVALNHTAGLSTPQQVQMVLFSLFALMDEADAYKQALK 412 Query: 367 AYRERRDFLVKSLGDIKGVKISEPQGAFYLFIDF----SAYYGSEAEGFGLINDSS-SLA 421 RR+ + + ++ + +Y ID YG + + S+ + Sbjct: 413 QLIRRREATLYRELGMPPLE-NPNSVNYYTLIDLQNVTCRLYGEAFSQWAVQQSSTGDML 471 Query: 422 LYFLDKFQVAMVPGDAFGDD-SCIRISYAT----SLDVLQAAVEKIRKAL 466 D+ + ++PG FG D R S A + A+ ++ L Sbjct: 472 FRVADETGIVLLPGRGFGSDRPSGRASLANLNEYEYAAIGRALRRLADEL 521 >4WBT-A nrPDB Length = 376 Score = 147 bits (372), Expect = 8e-36, Method: Composition-based stats. Identities = 90/408 (22%), Positives = 147/408 (36%), Gaps = 46/408 (11%) Query: 71 SLSPRVQSLKPSKTMVITDLAATLVQSGVPVI-RLAAGEPDFDTPKVVAEAGINAIREGF 129 +P +QSL S + A Q G + R+ A E F V A A + + Sbjct: 9 RFTPLIQSLPAS--VPFVGPEALERQHGRKIAARIGANESGFGPAPSVLLAIRQAAGDTW 66 Query: 130 TRYTLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIP 189 +Y +L++A+ R L +P I + G L Q V V G V+ Sbjct: 67 -KYADPE-NHDLKQALARHL------GTSPANIAIGEGIDGLLGQIVRLVVEAGAPVVTS 118 Query: 190 APYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLT----EKSRLLILCSPSNPT 245 + ++ V +P + D +DLE L E + L+ L +P NP Sbjct: 119 LGGYPTFNYHVAGHGGRLVTVP------YADDREDLEGLLAAVGRENAPLVYLANPDNPM 172 Query: 246 GSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFS 305 GS +P + A+ + + L++ DE Y A SL D + FS Sbjct: 173 GSWWPAERVVAFAQALPETT--LLVLDEAYCETAPRDAL-PPIESLID-KPNVIRARTFS 228 Query: 306 KAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMV 365 KA+ + G R+GY A K++ + GVAA A + + E+ Sbjct: 229 KAYGLAGARIGYTLSTPGTAQAFDKIRNHFGMS------RIGVAAAIAALADQDYLKEVT 282 Query: 366 KAYRERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFL 425 R + + G+ P ++ +D G +A I D + Sbjct: 283 LKIANSRQR-IGRIAADSGLAPL-PSATNFVAVDC----GKDASYARAIVD------RLM 330 Query: 426 DKFQVAM-VPGDAFGDDSCIRISYATSLDVLQAAVEKIRKALEPLRAT 472 + + +PG A + CIRIS A + + + + L AT Sbjct: 331 SDHGIFIRMPGVA-PLNRCIRISTA-PDAEMDLLAAALPEVIRSLAAT 376 >1LC8-A nrPDB Length = 364 Score = 145 bits (365), Expect = 4e-35, Method: Composition-based stats. Identities = 58/297 (19%), Positives = 105/297 (35%), Gaps = 20/297 (6%) Query: 101 VIRLAAGEPDFDTPKVVAEAGINAIREGFTRYTLNAGITELREAICRKLKEENGLSYAPD 160 ++ +A P V A I+ + RY L +A+ R + Sbjct: 26 LLDFSANINPLGMPVSVKRALIDNLD-CIERYPDAD-YFHLHQALARHHQ------VPAS 77 Query: 161 QILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNNFLL 220 IL NG +S+ + +I P + Y + + ++ + L Sbjct: 78 WILAGNGETESIFTVASGLKPR--RAMIVTPGFAEYGRALAQSGCEIRRWSLREADGWQL 135 Query: 221 DPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIY 280 LE LT L LC+P+NPTG + + LL+ IA L+L + + I + Sbjct: 136 TDAILE-ALTPDLDCLFLCTPNNPTGLLPERPLLQAIADRCKSLNINLILDEAFIDFIPH 194 Query: 281 APATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGAS 340 + P ++ + +K +A+ G RLGYL A + + Q+ + Sbjct: 195 ETGFIPALKDNPHIW----VLRSLTKFYAIPGLRLGYLVNSDDAAMARMR-RQQMPWSVN 249 Query: 341 SIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLGDIKGVKISEPQGAFYLF 397 ++A AG AL RE ++L + + + + + L Sbjct: 250 ALAALAGEVAL----QDSAWQQATWHWLREEGARFYQALCQLPLLTVYPGRANYLLL 302 >3P1T-A nrPDB Length = 337 Score = 139 bits (350), Expect = 3e-33, Method: Composition-based stats. Identities = 73/383 (19%), Positives = 134/383 (34%), Gaps = 55/383 (14%) Query: 85 MVITDLAATLVQSGVPVIRLAAGEPDFDTPKVVAEAGINAIREGFTRYTLNAGITELREA 144 M + + T V++ + LA E + + +A I A RY +A + Sbjct: 2 MSVGEAMDTEVRAAAQAVCLAFNENP-EAVEPRVQAAIAAAAARINRYPFDA-EPRVMRK 59 Query: 145 ICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLAD 204 + D +++ G + + S + P + Y + ++ Sbjct: 60 LAEHFSCPE------DNLMLVRGIDECFDRISAEFSSM--RFVTAWPGFDGYRARIAVSG 111 Query: 205 ATPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKH 264 I + + ++L +PSNPTG L+++ + K Sbjct: 112 LRHFEIGLTDDLL----LDPNDLAQVSRDDCVVLANPSNPTGQALSAGELDQLRQRAGK- 166 Query: 265 PRLLVLSDEIYEHIIYAPATHTSFASLPDMY-ERTLTVNGFSKAFAMTGWRLGYLAGPKH 323 +L DE Y ++SF + Y E L FSK++ + G RLG L GP Sbjct: 167 ----LLIDETYVD-------YSSFRARGLAYGENELVFRSFSKSYGLAGLRLGALFGPSE 215 Query: 324 IVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLGDIK 383 ++AA + Q ++ A AAL +A +A+ + R + +L + Sbjct: 216 LIAAMKRKQ--WFCNVGTLDLHALEAALDNDRAREAHIAKTLAQ----RRRVADALRGL- 268 Query: 384 GVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVAMVPGDAFGDDSC 443 G +++ + F L + N + L FL + + + FG Sbjct: 269 GYRVASSEANFVL----------------VENAAGERTLRFLRERGIQVKDAGQFGLHHH 312 Query: 444 IRISYATSLDVLQAAVEKIRKAL 466 IRIS D +++ AL Sbjct: 313 IRISIGREEDN-----DRLLAAL 330 >3IF2-A nrPDB Length = 444 Score = 134 bits (337), Expect = 8e-32, Method: Composition-based stats. Identities = 83/460 (18%), Positives = 157/460 (34%), Gaps = 81/460 (17%) Query: 70 MSLSPRVQSL-KPSKTMVITDLAATLVQSGVPVIRLAAGEP------------------- 109 M S Q +P+ + D ++S PV L G P Sbjct: 2 MKFSKFGQKFTQPTGISQLMDDLGDALKSDQPVNMLGGGNPAKIDAVNELFLETYKALGN 61 Query: 110 DFDTPKVVAEAGINAIREGFTRYTLNAGITELREAICRKLKEENGLSYAPDQILVSNGAK 169 D DT K + A I+ Y+ G + +A+ + + I ++NG++ Sbjct: 62 DNDTGKANSSAIISMAN-----YSNPQGDSAFIDALVGFFNRHYDWNLTSENIALTNGSQ 116 Query: 170 QSLLQAVL----AVCSPGDE----------VIIP-APYWVSYTEQARLADATPVVIPT-- 212 + A + + +++P P ++ Y++ V+P Sbjct: 117 NAFFYLFNLFGGAFVNEHSQDKESKSVDKSILLPLTPEYIGYSDVHVEGQHFAAVLPHID 176 Query: 213 ----KISNNFL---LDPKDLES--KLTEKSRLLILCS-PSNPTGSVYPKSLLEEIARIIA 262 F +D + LE+ L E I CS P+NPTG+V + +A I Sbjct: 177 EVTHDGEEGFFKYRVDFEALENLPALKEGRIGAICCSRPTNPTGNVLTDEEMAHLAEIAK 236 Query: 263 KHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPK 322 ++ + ++ D Y + + ++ D T+ SK + G R G + Sbjct: 237 RY-DIPLIIDNAYG-MPFPNIIYSDAHLNWDN--NTILCFSLSKI-GLPGMRTGIIVADA 291 Query: 323 HIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLGDI 382 ++ A S + V+ + + + + E+ Y+++ VK L Sbjct: 292 KVIEAVSAMNAVVNLAPTRFGAAIATPLVANDRIKQLSDNEIKPFYQKQATLAVKLLKQA 351 Query: 383 KG---VKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVAMVPGDAF- 438 G + I +P+GA +L++ F S + + L +VP + F Sbjct: 352 LGDYPLMIHKPEGAIFLWLWFKDLPISTLDLY-----------ERLKAKGTLIVPSEYFF 400 Query: 439 ---------GDDSCIRISYATSLDVLQAAVEKIRKALEPL 469 CIR+S A L ++ I + + L Sbjct: 401 PGVDVSDYQHAHECIRMSIAADEQTLIDGIKVIGEVVREL 440 >3G7Q-A nrPDB Length = 417 Score = 125 bits (315), Expect = 3e-29, Method: Composition-based stats. Identities = 79/418 (18%), Positives = 148/418 (35%), Gaps = 54/418 (12%) Query: 83 KTMVITDLAATLVQSGVPVIRLAAGEPDFDTP--KVVAEAGINAIREGFTR-----YTLN 135 T ++ DL L G I L G P + + G Y Sbjct: 17 ITRLMEDLNDGLRTPGA--IMLGGGNPAHIPAMQDYFQTLLTDMVESGKAADALCNYDGP 74 Query: 136 AGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSP---GD--EVIIP- 189 G T L A+ L+E G P I ++NG++ + G +V+ P Sbjct: 75 QGKTALLNALAVLLRETLGWDIEPQNIALTNGSQSAFFYLFNLFAGRRADGSTKKVLFPL 134 Query: 190 APYWVSYTEQA----RLADATPVVIPTKISNNFLL--DPKDLESKLTEKSRLLILCSPSN 243 AP ++ Y + A P I F D + L + E++ ++ + P+N Sbjct: 135 APEYIGYADSGLEDDLFVSARP-NIELLPEGQFKYHVDFEHLH--IGEETGMICVSRPTN 191 Query: 244 PTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNG 303 PTG+V L ++ R+ +H + ++ D Y + + + L + + Sbjct: 192 PTGNVITDEELMKLDRLANQH-NIPLVIDNAYG-VPFPGIIFSEARPLWN--PNIILCMS 247 Query: 304 FSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAE 363 SK + G R G + + A + + G +S + + + Sbjct: 248 LSK-LGLPGSRCGIIIANDKTITAIANMNGIISLAPGGMGPAMMCEMIKRNDLLRLSETV 306 Query: 364 MVKAYRERRD----FLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSS 419 + Y +R + + L + + + I +P+GA +L++ F + + Sbjct: 307 IKPFYYQRVQQTIAIIRRYLSEERCL-IHKPEGAIFLWLWFKDLPIT-----------TE 354 Query: 420 LALYFLDKFQVAMVPGDAF---------GDDSCIRISYATSLDVLQAAVEKIRKALEP 468 L L V MVPG F C+R++Y D ++A V+ + + +E Sbjct: 355 LLYQRLKARGVLMVPGHYFFPGLDKPWPHTHQCMRMNYVPEPDKIEAGVKILAEEIER 412 >3G0T-A nrPDB Length = 437 Score = 118 bits (295), Expect = 5e-27, Method: Composition-based stats. Identities = 68/340 (20%), Positives = 114/340 (33%), Gaps = 38/340 (11%) Query: 75 RVQSLKPSKTMVITDLAATLVQS-GVPVIRLAAGEPDFDTPKVVAEAGINAIREGF-TRY 132 ++ L + + L L ++ G R+ G P P++ E I +REG + Y Sbjct: 19 HIKDLGMASIRDLVALVTNLEKATGTKFCRMEMGVPGLPAPQIGIETEIQKLREGVASIY 78 Query: 133 TLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAV----LAVCSPGDEVII 188 G+ EL++ R K + + + G+ Q + + + Sbjct: 79 PNLDGLPELKQEASRFAKLFVNIDIPARACVPTVGSMQGCFVSFLVANRTHKNREYGTLF 138 Query: 189 PAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRL-LILCSPSNPTGS 247 P + Q R+ L + LES L +I +P+NPT Sbjct: 139 IDPGFNLNKLQCRILGQKFESFDLFEYRGEKL-REKLESYLQTGQFCSIIYSNPNNPTWQ 197 Query: 248 VYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIY--------APATHTSFASLPDMYERTL 299 L I + KH ++V+ D Y + + P S A+ D Y + Sbjct: 198 CMTDEELRIIGELATKH-DVIVIEDLAYFGMDFRKDYSHPGEPLYQPSVANYTDNY---I 253 Query: 300 TVNGFSKAFAMTGWRLGYLAG--------PKHIVAACSKLQ----------GQVSSGASS 341 SKAF+ G R+G L + + +L+ +SSGA+ Sbjct: 254 LALSSSKAFSYAGQRIGVLMISGKLYEREYPDLEESFGRLRFGEALSSSALYALSSGATH 313 Query: 342 IAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLGD 381 AQ A L G + V Y + + K D Sbjct: 314 SAQWGMAAMLKACNDGEYNFRDSVIEYGRKARIMKKMFLD 353 >4EMY-A nrPDB Length = 413 Score = 111 bits (278), Expect = 6e-25, Method: Composition-based stats. Identities = 68/430 (15%), Positives = 131/430 (30%), Gaps = 54/430 (12%) Query: 65 SSSVDMSLSPRVQSLKPSKTMVITDLA-ATLVQSGVP-VIRLAAG-----EPDFDTPKVV 117 S+++ M++ + P I + A A + + G VI A G + V Sbjct: 1 SNAMPMTIKRATWNNGPDLAFDINNKANAAIEKYGREAVINAALGTLLDDKGKIIALPSV 60 Query: 118 AEAGINAIREGFTRYTLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVL 177 + R Y G + R+ + L I + G ++ A+ Sbjct: 61 YDRLDEMDRSHIASYAPIEGEKDYRKIVIDTLFGPYKPEGYISAI-ATPGGTGAIRSAIF 119 Query: 178 AVCSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSR--- 234 + GD +I YW Y + +++F + + + E R Sbjct: 120 SYLDEGDPLICHDYYWAPYRKICEEFGRNFKTFEF-FTDDFAFNIDVYKEAIDEGIRDSD 178 Query: 235 --LLILCSP-SNPTGSVYPKSLLEEIARII-----AKHPRLLVLSDEIYEHIIYAPATHT 286 ++ SP +NPTG +E+ + K ++ ++ D Y Sbjct: 179 RIASLINSPGNNPTGYSLSDEEWDEVITFLKEKAEDKDKKITLIVDVAYLEFAGDGDQQR 238 Query: 287 SFASLPDMYER---TLTVNGFSKAFAMTGWRLGYLAG---PKHIVAACSKLQGQVSSGAS 340 F R + SK+ G R G G K I+ + Sbjct: 239 KFFEKFSNLPRNLFVVVAFSMSKSHTAYGLRSGAAVGISSSKEIIEEFEASLAHSARCNW 298 Query: 341 SIAQKAGVAAL------GLGKAGGETVAEMVKAYRERRDFLVKSLGDIKGVKISEPQGAF 394 S A L K + + ++ + R D V + + + G F Sbjct: 299 SNGTHAAQNILIELERAENKKIYEQELVDLRNMLKSRADVFVTA-AKENKLTMIPYFGGF 357 Query: 395 YLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVAMVPGDAFGDDSCIRISYAT-SLD 453 + FI + F ++ D L+K + +P IR++ + Sbjct: 358 FTFI-------PTDKAFDIVKD--------LEKENIFTIP-----SAKGIRVAICGVGEE 397 Query: 454 VLQAAVEKIR 463 + V+++ Sbjct: 398 KIPKLVQRLA 407 >5DJ3-A nrPDB Length = 376 Score = 99.4 bits (246), Expect = 3e-21, Method: Composition-based stats. Identities = 60/322 (18%), Positives = 119/322 (36%), Gaps = 27/322 (8%) Query: 152 ENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADATPVVIP 211 ++G P ++L + S+ ++ + D V + P + + + R V + Sbjct: 74 QHGYPAEPGRVLSCYSSSVSMEILARSLSASVDRVALVHPTFDNIADLLRGNGLDLVPVE 133 Query: 212 TKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLS 271 + DL ++L + + +P+NPTG V + L +A A+H +L L Sbjct: 134 EDALHG-----ADLSAELLSSVGCVFVTTPNNPTGRVLAEERLRRLAEQCAEHGTVLAL- 187 Query: 272 DEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKL 331 D + A A + +A L + R + + K + + G L + I K+ Sbjct: 188 DTSFRGFD-AAAHYDHYAVLQEAGCRWVVIEDTGKLWPTLDLKAGLLVFSEDIGLPVEKI 246 Query: 332 QGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLGDIKGVKISEPQ 391 + G S + GG +A++ R + ++L ++GV +P+ Sbjct: 247 YSDILLGVSPLILALIREFSRDAADGG--LADLHAFILHNRSVVRRALAGVEGVSFPDPE 304 Query: 392 GAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVAMVPGDAFG------DDSCIR 445 S E + + L + V +P F D +R Sbjct: 305 ------------SRSSVERVAFAGRTGTEVWEELQRHHVFALPCRQFHWAEPSDGDHMVR 352 Query: 446 ISYATSLDVLQAAVEKIRKALE 467 I+ + S + L+ +V+ +R LE Sbjct: 353 IALSRSTEPLEKSVQVLRTVLE 374 >3RQ1-A nrPDB Length = 418 Score = 98.6 bits (244), Expect = 5e-21, Method: Composition-based stats. Identities = 77/431 (17%), Positives = 140/431 (32%), Gaps = 60/431 (13%) Query: 73 SPRVQSLKPSKTMVITDLAATLVQSGVP-VIRLAAG-----EPDFDTPKVVAEAGINAIR 126 + + LK + A ++G V+ G E + K V E ++ Sbjct: 11 HAKGKKLKDVIFVTAGQAQADAKENGRENVVNGTLGAIHDEEGNLVFLKTVKEEYLSLSD 70 Query: 127 EGFTRYTLNAGITELREAICRKLKEENGLSYAPD-QI--LVSNGAKQSLLQAVLAVCSPG 183 Y AGI + +C KE G ++ P+ I + + G + + PG Sbjct: 71 SEHVGYAPIAGIPDF---LCAAEKECFG-NFRPEGHIRSIATAGGTGGIHHLIHNYTEPG 126 Query: 184 DEVIIPAPYWVSYTEQARLADATPVVIPTKISNN------FLLDPKDLESKLTEKSRLLI 237 DEV+ YW +Y T V +N F +L +K T ++I Sbjct: 127 DEVLTADWYWGAYRVICSDTGRTLVTYSLFDEHNNFNHEAFQNRVNELAAKQTN--VVVI 184 Query: 238 LCSP-SNPTGSVYPKSLLEEIARIIA-----KHPRLLVLSDEIYEHIIYAPATHTSFASL 291 +P +NPTG + I + +++ D Y +F + Sbjct: 185 FNTPGNNPTGYSIEDKDWDSILNFLKDLVAIGRNNVIIGIDVAYLDYSGEKDEVRAFFNK 244 Query: 292 PDMYERTL---TVNGFSKAFAMTGWRLGYLAG---PKHIVAACSKLQGQVS----SGASS 341 + + SK F M G R+G + G + I ++ S S Sbjct: 245 FSHLPKEILTCVCYSLSKGFTMYGQRVGAMIGISDDEEIADEFFEVNKSTSRATWSNICR 304 Query: 342 IAQKAGVAALGLGKAGGETVAEMVKAYRERRDF--LVKSLGDIKGVKISEPQGAFYLFID 399 A + + E AE Y+ RD + K G+ + +G F++ Sbjct: 305 PAMRTMANIVADPAKFKEYEAERNCYYQLIRDRADIFKQEAAQVGLPMLPYRGGFFI--- 361 Query: 400 FSAYYGSEAEGFGLINDSSSLALYFLDKFQVAMVPGDAFGDDSCIRISYAT-SLDVLQAA 458 + ++++ K + ++ + IRI+ + Sbjct: 362 -----------TIPTDSANAICEEL-KKEHIYVIALA-----NGIRIAACGIPKCQMTGL 404 Query: 459 VEKIRKALEPL 469 EKI A++ L Sbjct: 405 AEKIYNAMKSL 415 >3BWN-A nrPDB Length = 391 Score = 92.5 bits (228), Expect = 4e-19, Method: Composition-based stats. Identities = 61/341 (17%), Positives = 117/341 (34%), Gaps = 44/341 (12%) Query: 139 TELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDE----VIIPAPYWV 194 EL +AI + I+V G+ Q AV A+ S V+ AP++ Sbjct: 71 PELEDAIKDLHGVVGNAATEDRYIVVGTGSTQLCQAAVHALSSLARSQPVSVVAAAPFYS 130 Query: 195 SYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLL 254 +Y E+ + + + D + + ++ SP+NP G++ Sbjct: 131 TYVEETTYVRSGMYKW---EGDAWGFD--------KKGPYIELVTSPNNPDGTI-----R 174 Query: 255 EEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWR 314 E + V+ D Y Y P + + + + FSK G R Sbjct: 175 ETVVNR-PDDDEAKVIHDFAYYWPHYTP--------ITRRQDHDIMLFTFSKITGHAGSR 225 Query: 315 LGY-LAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRD 373 +G+ L K + + S G S +Q L + K ++ +E ++ R+ Sbjct: 226 IGWALVKDKEVAKKMVEYIIVNSIGVSKESQVRTAKILNVLKETCKSESESENFFKYGRE 285 Query: 374 FLVKSLGDIKGVKISEPQGAFYLFID----FSAYYGSEAEGFGLI-----NDSSSLALYF 424 + ++ V + E + F Y+G E + + + L Sbjct: 286 MMKNRWEKLREV-VKESDA--FTLPKYPEAFCNYFGKSLESYPAFAWLGTKEETDLVSEL 342 Query: 425 LDKFQVAMVPGDAFGDD-SCIRISYATSLDVLQAAVEKIRK 464 + +V G+ G D +R+S + DV +E++ Sbjct: 343 -RRHKVMSRAGERCGSDKKHVRVSMLSREDVFNVFLERLAN 382 >3EZ1-A nrPDB Length = 423 Score = 86.7 bits (213), Expect = 2e-17, Method: Composition-based stats. Identities = 62/381 (16%), Positives = 121/381 (31%), Gaps = 65/381 (17%) Query: 130 TRYTLNAGITELREAICRKLKEENGLSYAPDQILVSNGAK---QSLLQAVLAV------- 179 AG+ R L + +LV N + Q L+ + Sbjct: 64 NYPGGVAGLPSARALFAGYL------DVKAENVLVWNNSSLELQGLVLTFALLHGVRGST 117 Query: 180 ---CSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKL--TEKSR 234 S ++I+ P + + + + + + D +E + Sbjct: 118 GPWLSQTPKMIVTVPGYDRHFLLLQTLGFELLTVDMQSD---GPDVDAVERLAGTDPSVK 174 Query: 235 -LLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIY------EHIIYAPATHTS 287 +L + + SNP G +A + A P + +D+ Y E P Sbjct: 175 GILFVPTYSNPGGETISLEKARRLAGLQAAAPDFTIFADDAYRVHHLVEEDRAEPVNFVV 234 Query: 288 FASLPDMYERTLTVNGFSK-AFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKA 346 A +R SK FA G LG++A + + SK G S G + + Q Sbjct: 235 LARDAGYPDRAFVFASTSKITFAGAG--LGFVASSEDNIRWLSKYLGAQSIGPNKVEQAR 292 Query: 347 GVAALGLGKAGGE-TVAEMVKAYRERRDFLVKSLGDIKG-----VKISEPQGAFYLFIDF 400 V L G E + + + + + L G + P+G +++ +D Sbjct: 293 HVKFLTEYPGGLEGLMRDHAAIIAPKFRAVDEVLRAELGEGGEYATWTLPKGGYFISLDT 352 Query: 401 SAYYGSEAEGFGLINDSSSLALYFLDKFQVAMVPGDA---FGDDSC---IRISYATSLDV 454 + + + + V++ P A G D +R++ Sbjct: 353 A-------------EPVADRVVKLAEAAGVSLTPAGATYPAGQDPHNRNLRLAPTRP--- 396 Query: 455 LQAAVEKIRKALEPLRATVSV 475 VE++R A++ + A + + Sbjct: 397 ---PVEEVRTAMQVVAACIRL 414 >1AY8-A nrPDB Length = 394 Score = 85.6 bits (210), Expect = 4e-17, Method: Composition-based stats. Identities = 68/407 (16%), Positives = 126/407 (30%), Gaps = 55/407 (13%) Query: 81 PSKTMVITDLAATLVQSGVPVIRLAAG---EPDFDTP--KVVAEAGINAIREGFTR-YTL 134 P K + + + G I L G + TP + V A + T+ Y Sbjct: 10 PDKILALMGEFRADPRQGK--IDLGVGVYKDATGHTPIMRAVHAAEQRMLETETTKTYAG 67 Query: 135 NAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLA--VCSPGDEVIIPAPY 192 +G E ++A+ + + GL L + G +L QA+ + +P V + P Sbjct: 68 LSGEPEFQKAMGELILGD-GLKSETTATLATVGGTGALRQALELARMANPDLRVFVSDPT 126 Query: 193 WVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLIL-----CSPSNPTGS 247 W ++ + +D + +++ L + ++ C NPTG+ Sbjct: 127 WPNHVSIMNFMGLPVQTYRYFDAETRGVDFEGMKADLAAAKKGDMVLLHGCC--HNPTGA 184 Query: 248 VYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFAS---LPDMYERTLTVNGF 304 EIA I+ K L ++ D Y+ + A + L Sbjct: 185 NLTLDQWAEIASILEKTGALPLI-DLAYQG--FGDGLEEDAAGTRLIASRIPEVLIAASC 241 Query: 305 SKAFAMTGWRLGYL------AGPKHIVAACSKLQGQVSSGASSIAQKAGVAA-LGLGKAG 357 SK F + R G L A + + + + V+ L + Sbjct: 242 SKNFGIYRERTGCLLALCADAATRELAQGAMAFLNRQTYSFPPFHGAKIVSTVLTTPELR 301 Query: 358 GETVAEM---VKAYRERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLI 414 + +AE+ R+ L L D+ G D + F + Sbjct: 302 ADWMAELEAVRSGMLRLREQLAGELRDLSG-------------SDRFGFVAEHRGMFSRL 348 Query: 415 NDSSSLALYFLDKFQVAMVPGDAFGDDSCIRISYATSLDVLQAAVEK 461 + ++F + MV RI+ A D + + Sbjct: 349 GATPEQVKRIKEEFGIYMV--------GDSRINIAGLNDNTIPILAR 387 >3UWC-A nrPDB Length = 374 Score = 84.4 bits (207), Expect = 1e-16, Method: Composition-based stats. Identities = 34/133 (25%), Positives = 62/133 (46%), Gaps = 9/133 (6%) Query: 141 LREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQA 200 L + + K L AP I V G + + GDEVI A +++ Sbjct: 36 LGAELEKFEKRFAALHNAPHAIGVGTGTDALAMSFKMLNIGAGDEVITCANTFIASVGAI 95 Query: 201 RLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARI 260 A ATPV++ + N +++DP+ +E+ +T+K++ ++ P + TG++ L +I Sbjct: 96 VQAGATPVLVDS--ENGYVIDPEKIEAAITDKTKAIM---PVHYTGNIADMPALAKI--- 147 Query: 261 IAKHPRLLVLSDE 273 AK L ++ D Sbjct: 148 -AKKHNLHIVEDA 159 >3DR4-A nrPDB Length = 391 Score = 84.4 bits (207), Expect = 1e-16, Method: Composition-based stats. Identities = 54/265 (20%), Positives = 88/265 (33%), Gaps = 38/265 (14%) Query: 145 ICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLAD 204 I K I +NG L V PGDEVI+P+ +++ Sbjct: 58 IVEFEKAFADYCGVKHAIACNNGTTALHLALVAMGIGPGDEVIVPSLTYIASANSVTYCG 117 Query: 205 ATPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKH 264 ATPV++ F LD LE+ +T +++ ++ P + G + + E+AR Sbjct: 118 ATPVLVDNDPRT-FNLDAAKLEALITPRTKAIM---PVHLYGQICDMDPILEVARR---- 169 Query: 265 PRLLVLSDEIYE-HIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKH 323 LLV+ D Y S T + F A TG Sbjct: 170 HNLLVIEDAAEAVGATYRGKKSGSLGDCA-------TFSFFGNAIITTGEGGMITTNDDD 222 Query: 324 IVAACSKLQGQ--------------VSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYR 369 + A L+GQ + ++I G+A L +V Y Sbjct: 223 LAAKMRLLRGQGMDPNRRYWFPIVGFNYRMTNIQAAIGLAQLERVDEHLAARERVVGWYE 282 Query: 370 ERRDFLVKSLGDIKGVKISEPQGAF 394 ++ L G ++++P A Sbjct: 283 QKLARL--------GNRVTKPHVAL 299 >4K2M-A nrPDB Length = 443 Score = 83.2 bits (204), Expect = 2e-16, Method: Composition-based stats. Identities = 34/218 (15%), Positives = 76/218 (34%), Gaps = 28/218 (12%) Query: 118 AEAGINAIRE--GFTRYTLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQA 175 E +N + E ++T + + + + L + ++ ++ +++ Sbjct: 83 VEDILNTLTEVLPTGKFTSGPYLEQFEKVLSTYLHKRY--------VIATSSGTDAIMIG 134 Query: 176 VLAV-CSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSR 234 +LA+ +PGDEVI+PA + + + P+ + F +DP +E +T ++ Sbjct: 135 LLALGLNPGDEVIMPANSFSATENAVLASGGVPIYVDINPQT-FCIDPDKIEEAITPYTK 193 Query: 235 LLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDM 294 ++ P + G + +IA +L V+ D L Sbjct: 194 FIL---PVHLYGKHSDMQHIRQIANR----YKLKVIEDACQG---------IGLTDLGKY 237 Query: 295 YERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQ 332 + T K F + G + + C + Sbjct: 238 ADITTLSFNPYKNFGVCGKAGAIATDNEELAKKCIQFS 275 >3FSL-A nrPDB Length = 397 Score = 83.2 bits (204), Expect = 2e-16, Method: Composition-based stats. Identities = 67/381 (17%), Positives = 132/381 (34%), Gaps = 35/381 (9%) Query: 75 RVQSLKPSKTMVITDLAATLVQSGVPVIRLAAG---EPDFDTPKVVA----EAGINAIRE 127 +V + + + + +S + L+ G D P++ A EA +NA Sbjct: 4 KVDAYAGDPILTLMERFKEDPRSDK--VNLSIGLYYNEDGIIPQLQAVAEAEARLNAQPH 61 Query: 128 GFTRYTLNAGITELREAICRKLKEENGLSYAPDQI--LVSNGAKQSLLQAVLAVCS---P 182 G + Y G+ R AI L + ++ + + G +L + P Sbjct: 62 GASLYLPMEGLNCYRHAIAPLLFGADHPVLKQQRVATIQTLGGSGAL-KVGADFLKRYFP 120 Query: 183 GDEVIIPAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTE-KSRLLILCSP 241 V + P W ++ A P + DL + L ++ ++L P Sbjct: 121 ESGVWVSDPTWENHVAIFAGAGFEVSTYPWYDEATNGVRFNDLLATLKTLQAGSIVLLHP 180 Query: 242 --SNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHI-IYAPATHTSFASLPDMYERT 298 NPTG+ + + I+ + L D Y+ + ++ Sbjct: 181 CCHNPTGADLTNDQWDAVIEILKARELIPFL-DIAYQGFGAGMEEDAYAIRAIASAGLPA 239 Query: 299 LTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQV------SSGASSIAQKAGVAALG 352 L N FSK F++ G R+G L+ A ++ GQ+ + + VAA+ Sbjct: 240 LVSNSFSKIFSLYGERVGGLSVMCEDAEAAGRVLGQLKATVRRNYSSPPNFGAQVVAAVL 299 Query: 353 LGKAGGETVAEMVKAYRERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFG 412 +A + + V+ R R + + L + + P+ F Y ++ F Sbjct: 300 NDEALKASWLKEVEEMRTRILAMRQELVKV--LSTEMPERNF-------DYLLNQRGMFS 350 Query: 413 LINDSSSLALYFLDKFQVAMV 433 S++ ++F V ++ Sbjct: 351 YTGLSAAQVDRLREEFGVYLI 371 >4F5M-A nrPDB Length = 406 Score = 82.9 bits (203), Expect = 3e-16, Method: Composition-based stats. Identities = 65/382 (17%), Positives = 121/382 (31%), Gaps = 40/382 (10%) Query: 76 VQSLKPSKTMVITDLAATLVQSGVPVIRLAAG---EPDFDTPKV--VAEAGINAIREGFT 130 + + + + DL + G I L G + TP + V +A + T Sbjct: 15 ITAAPADPILGLADLFRADERPGK--INLGIGVYKDETGKTPVLTSVKKAEQYLLENETT 72 Query: 131 R-YTLNAGITELREAICRKLKEENGLSYAPDQI--LVSNGAKQSLLQAVLAVCSPGD--E 185 + Y GI E L + + + G +L A + Sbjct: 73 KNYLGIDGIPEFGRCTQELLFGKGSALINDKRARTAQTPGGTGALRVAADFLAKNTSVKR 132 Query: 186 VIIPAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTE---KSRLLILCSPS 242 V + P W ++ A + N LD L + L E +L Sbjct: 133 VWVSNPSWPNHKSVFNSAGLEVREYAYYDAENHTLDFDALINSLNEAQAGDVVLFHGCCH 192 Query: 243 NPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYA-PATHTSFASLPDMYERTLTV 301 NPTG + +A++ + L L D Y+ + M++ + Sbjct: 193 NPTGIDPTLEQWQTLAQLSVEKGWLP-LFDFAYQGFARGLEEDAEGLRAFAAMHKELIVA 251 Query: 302 NGFSKAFAMTGWRLG----YLAGPKHIVAACSKLQGQVSSGASSIAQK-AGVAALGLGKA 356 + +SK F + R+G A + + A S+++ + + S+ A V A L Sbjct: 252 SSYSKNFGLYNERVGACTLVAADSETVDRAFSQMKAAIRANYSNPPAHGASVVATILSND 311 Query: 357 G-----GETVAEMVKAYRERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGF 411 + + +M + + R V +L + + DFS + + F Sbjct: 312 ALRAIWEQELTDMRQRIQRMRQLFVNTLQEKGANR------------DFS-FIIKQNGMF 358 Query: 412 GLINDSSSLALYFLDKFQVAMV 433 + L ++F V V Sbjct: 359 SFSGLTKEQVLRLREEFGVYAV 380 >3NYS-A nrPDB Length = 367 Score = 82.1 bits (201), Expect = 5e-16, Method: Composition-based stats. Identities = 45/217 (20%), Positives = 77/217 (35%), Gaps = 27/217 (12%) Query: 118 AEAGINAIREGFTRYTLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVL 177 +AGI + +Y L +TEL + + + + I +NG +L + Sbjct: 18 IDAGIQRVLRH-GQYILGPEVTELEDRLADFVGAKYC-------ISCANGTD-ALQIVQM 68 Query: 178 AV-CSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLL 236 A+ PGDEVI P +V+ E L A PV + + LDP+ LE+ +T +++ + Sbjct: 69 ALGVGPGDEVITPGFTYVATAETVALLGAKPVYVDIDPRT-YNLDPQLLEAAITPRTKAI 127 Query: 237 ILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYE 296 I P + G + I A + V+ D + S Sbjct: 128 I---PVSLYGQCADFDAINAI----ASKYGIPVIEDAAQSFGASYKGKRSCNLS------ 174 Query: 297 RTLTVNGF--SKAFAMTGWRLGYLAGPKHIVAACSKL 331 T+ F S G + A ++ Sbjct: 175 -TVACTSFFPSAPLGCYGDGGAIFTNDDELATAIRQI 210 >2C81-A nrPDB Length = 418 Score = 80.5 bits (197), Expect = 1e-15, Method: Composition-based stats. Identities = 56/342 (16%), Positives = 120/342 (35%), Gaps = 59/342 (17%) Query: 118 AEAGINAIREGFTRYTLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVL 177 E + R + Y G + + + NG+ Y + ++G+ +L+ A+ Sbjct: 22 IEEVFQSNRWAISGYWT--GEESMERKFAKAFADFNGVPYC---VPTTSGST-ALMLALE 75 Query: 178 AV-CSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLL 236 A+ GDEVI+P+ W++ +A PV + ++ + +DP+ ++S +T+K++ + Sbjct: 76 ALGIGEGDEVIVPSLTWIATATAVLNVNALPVFVDV-EADTYCIDPQLIKSAITDKTKAI 134 Query: 237 ILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEH-IIYAPATHTSFASLPDMY 295 I P + GS+ + EI A+ L V+ D H ++ + Sbjct: 135 I---PVHLFGSMANMDEINEI----AQEHNLFVIEDCAQSHGSVWNNQRAGTIGD----- 182 Query: 296 ERTLTVNGFSKAFA--MTGWRLGYLAG-PKHIVAACSKLQGQVSSGASSIAQKAGVAALG 352 + FS +T G + + +L+ ++ Sbjct: 183 -----IGAFSCQQGKVLTAGEGGIIVTKNPRLFELIQQLRADSRVYCDDSSELMHGDMQL 237 Query: 353 LGKAG-------------------GETVAEMVKAYRERRDFLVKSLGDIKGVKIS--EPQ 391 + K + + + + FL +L I G+K+ PQ Sbjct: 238 VKKGDIQGSNYCLSEFQSAILLDQLQELDDKNAIREKNAMFLNDALSKIDGIKVMKRPPQ 297 Query: 392 G---AFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQV 430 +Y ++ + + FG +N +K + Sbjct: 298 VSRQTYYGYV-----FRFDPVKFGGLNAD-QFCEILREKLNM 333 >6C3C-A nrPDB Length = 413 Score = 80.2 bits (196), Expect = 2e-15, Method: Composition-based stats. Identities = 71/425 (16%), Positives = 143/425 (33%), Gaps = 54/425 (12%) Query: 71 SLSPRVQSLKPSKTMVITDLAATLVQSGVPVIRLAAGEPDFDTPKVVAEAGINAIREGFT 130 L PR + P T G P++ L E T K R+ + Sbjct: 13 GLVPRGSHMHPQAT----------PAPGAPLLDLTQHEIQALTMKYNLADAHTHQRQSAS 62 Query: 131 RYTLNAGITEL----REAICRKLKEEN-----GLSYAPDQIL-----VSNGAKQSLLQAV 176 + ++ + + +L E + ++ L P ++ +S A S + A Sbjct: 63 QQSIVSRLPQLWYEAEEGLQATYEKRFTEAFFQLHRQPTALVKNKTMLSYAASISTMVAG 122 Query: 177 LAVCSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNNFLLD--PKDLESKLTEKSR 234 + + V + P + + + LA+ + P S + +D +LE ++ ++ Sbjct: 123 MFLKKERLAVTLIEPCFDNLYDV--LANMDVPLYPIDESVFYDVDRIYPELERRV--RTD 178 Query: 235 LLILCSPSNPTGSVY---PKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAP--ATHTSFA 289 L L P+NPTG + EE+ R H +LL++ ++ P A + Sbjct: 179 ALFLVDPNNPTGFSLLRHGRKGFEEVVRFCKDHDKLLLIDFCFASFTLFEPELARFDMYE 238 Query: 290 SLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVA 349 L + R L + K + + + + I L V S + Sbjct: 239 LLENSGVRYLAIEDTGKTWPVQDAKCALITASDDIWETVYNLHTSVLLNVSPFVL--NML 296 Query: 350 ALGLGKAGGETVAEMVKAYRERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAE 409 + + + +A + + R+ K+L ++ EP + S + Sbjct: 297 TQYVRDSAADRLASVREVLTRNRECARKTLDGSI-LEYQEP------VVKVSVAWFRVDH 349 Query: 410 GFGLINDSSSLALYFLDKFQVAMVPGDAFG------DDSCIRISYATSLDVLQAAVEKIR 463 D L V ++PG F D+ +R++ A ++ A+ R Sbjct: 350 PELTATD----VHRLLSADGVYVLPGRYFYWSEPSKGDAYVRMALAREPEMFADAMALTR 405 Query: 464 KALEP 468 + L+ Sbjct: 406 QVLDR 410 >4WD2-A nrPDB Length = 408 Score = 79.4 bits (194), Expect = 3e-15, Method: Composition-based stats. Identities = 72/393 (18%), Positives = 130/393 (33%), Gaps = 42/393 (10%) Query: 75 RVQSLKPSKTMVITDLAATLVQSGVPVIRLAAGE--------PDFDTPKVVAEAGINAIR 126 + + + + + + + L+ G P + A Sbjct: 12 HIDAYPGDPILTLNENFQKDPRDQK--VNLSIGIYFDAEGRIPVMGAVREAETALQR--D 67 Query: 127 EGFTRYTLNAGITELREAICRKLKEENGLSYAPDQI--LVSNGAKQSLLQAVLAVCS--- 181 G Y G+ R+A+ + + + A +I L + G +L + Sbjct: 68 SGPKPYLPMVGLAAYRDAVQSLVFGADHPARAAGRIATLQTLGGSGAL-KVGADFLKRYF 126 Query: 182 PGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTE-KSRLLIL-- 238 P +V + P W ++ A T P L + + + +R ++L Sbjct: 127 PDSQVWLSDPSWENHRFIFERAGFTVNTYPYYDEATGGLKFDAMLAAIDALPARSIVLLH 186 Query: 239 --CSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHI-IYAPATHTSFASLPDMY 295 C NPTG + E++ +I L + D Y+ A + L Sbjct: 187 ACC--HNPTGVDLDEGQWEKLIDVIEARELLPFV-DMAYQGFGAGLDADAFAVRELARRG 243 Query: 296 ERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVS----SGASSIAQKAG--VA 349 TL N FSK F++ G R+G L+ AA ++ GQ++ S S+ VA Sbjct: 244 VPTLVANSFSKNFSLYGERVGGLSVVCEDAAAAERVLGQLAGAVRSNYSNPQTYGAKVVA 303 Query: 350 AL----GLGKAGGETVAEMVKAYRERRDFLVKSLGDIK----GVKISEPQGAF-YLFIDF 400 A+ L K E ++ M + R + L D + + +G F Y + Sbjct: 304 AVLGTPALRKQWEEELSAMCRRIARMRQSIHDGLRDHVSGEALTRYVKQRGMFTYTGLTE 363 Query: 401 SAYYGSEAEGFGLINDSSSLALYFLDKFQVAMV 433 S I S + + L+ V +V Sbjct: 364 SQVDALREVHGVYILRSGRMCVAGLNDSNVGIV 396 >5IWQ-A nrPDB Length = 434 Score = 76.7 bits (187), Expect = 2e-14, Method: Composition-based stats. Identities = 51/430 (11%), Positives = 131/430 (30%), Gaps = 66/430 (15%) Query: 73 SPRVQSLKPSKTMVITDLAATLVQSGVPVIRLAAGEP--------DFDTPKVVAEAGINA 124 + R+ +L + ++ + L G+P D A Sbjct: 11 AERIGLFHEDIKRKFDELKSKNLK-----LDLTRGKPSSEQLDFADELLALPGKGDFKAA 65 Query: 125 IREGFTRYTLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLA---VCS 181 Y GI ++R+ L G+ +Q+L + + +++ V++ + Sbjct: 66 DGTDVRNYGGLDGIVDIRQIWADLL----GVPV--EQVLAGDASSLNIMFDVISWSYIFG 119 Query: 182 PGDEV-----------IIPAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLT 230 D V I P P + + + +P D +E + Sbjct: 120 NNDSVQPWSKEETVKWICPVPGYDRHFSITERFGFEMISVPMNED---GPDMDAVEELVK 176 Query: 231 -EKSRLLILC-SPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATH--T 286 + + + + SNPTG + + + ++ + P V+ D Y Sbjct: 177 NPQVKGMWVVPVFSNPTGFTVTEDVAKRLSAMETAAPDFRVVWDNAYAVHTLTDEFPEVI 236 Query: 287 SFASLPDMYERTLTVNGFSKAFA--MTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQ 344 L + F+ + G + + + G G + + Q Sbjct: 237 DIVGLGEAAGNPNRFWAFTSTSKITLAGAGVSFFLTSAENRKWYTGHAGIRGIGPNKVNQ 296 Query: 345 KAGVAALGLGKAGGETVAEMVKAYRERRDFLVK----SLGDIKGVKISEPQGAFYLFIDF 400 A G + + + + + + +++ L + + + P G +++ +D Sbjct: 297 LAHARYFGDAEGVRAVMRKHAASLAPKFNKVLEILDSRLAEYGVAQWTVPAGGYFISLDV 356 Query: 401 SAYYGSEAEGFGLINDSSSLALYFLDKFQVAMV-PGDAF-----GDDSCIRISYA-TSLD 453 S + +A+ G ++ ++ +R++ + ++ Sbjct: 357 VPGTASR-------------VAELAKEAGIALTGAGSSYPLRQDPENKNLRLAPSLPPVE 403 Query: 454 VLQAAVEKIR 463 L+ A++ + Sbjct: 404 ELEVAMDGVA 413 >4W5K-A nrPDB Length = 396 Score = 75.9 bits (185), Expect = 4e-14, Method: Composition-based stats. Identities = 49/310 (15%), Positives = 87/310 (28%), Gaps = 30/310 (9%) Query: 102 IRLAAG----EPDFDTPKVVAEAGINAIREGFTRYTLNAGITELREAICRKLKEENGLSY 157 + L+ G + D V E A Y GI E + + Sbjct: 31 VNLSIGVYRDDADQP---FVLECVKQATLGTNMDYAPVTGIASFVEEAQKLCFGPTCAAL 87 Query: 158 APDQI--LVSNGAKQSLLQ---AVLAVCSPGDEVIIPAPYWVSYTEQARLADATPVVI-- 210 +I + G +L + + + + P + ++ A Sbjct: 88 RDGRIASCQTLGGTGALRIGGDLLNRFVANCNRIYGPDVGYPNHESIFAKAGMELTPYSY 147 Query: 211 --PTKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLL 268 P N + L+ L+ C+ NPTG ++ +I + + Sbjct: 148 YDPATKGLNLAGMLECLDKAPEGSVILVHACA-HNPTGVDPTHDDWRQVCDVIKRRNHIP 206 Query: 269 VLSDEIYEHIIYAPATHTSFAS--LPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVA 326 + D Y+ + +F L DM + FS F + G R G L Sbjct: 207 FV-DMAYQGFATGQLDYDAFVPRHLVDMVPNLIVAQSFSANFGLYGHRCGALHISTASAE 265 Query: 327 ACSKLQGQVSSGA----SSIAQKAGVAALGLGKAGG------ETVAEMVKAYRERRDFLV 376 +L Q++ S+ + K + + +M E R LV Sbjct: 266 EAKRLVSQLALLIRPMYSNPPLYGAWVVSSILKDPQLTALWKKELKQMSSRIAEVRKRLV 325 Query: 377 KSLGDIKGVK 386 L V Sbjct: 326 SELKACGSVH 335 >4PIW-A nrPDB Length = 396 Score = 75.5 bits (184), Expect = 5e-14, Method: Composition-based stats. Identities = 58/365 (15%), Positives = 117/365 (32%), Gaps = 62/365 (16%) Query: 110 DFDTPKVVAEAGINAIREGFTRYTLNAGITELREAICRKLKEENGLSYAPDQILVSNGAK 169 F+ P VV + ++ G + L++ G + ++L++ Sbjct: 23 PFNAPPVVGTEL-DYMQSAMGS-GKLCGDGGFTRRCQQWLEQRFGSA----KVLLTPSCT 76 Query: 170 QSLLQAVLAV-CSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESK 228 SL A L + PGDEVI+P+ +VS L A V + + +D +E+ Sbjct: 77 ASLEMAALLLDIQPGDEVIMPSYTFVSTANAFVLRGAKIVFVDVRPDT-MNIDETLIEAA 135 Query: 229 LTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHI-IYAPATHTS 287 +T+K+R+++ P + G + + AK L V+ D + Y + Sbjct: 136 ITDKTRVIV---PVHYAGVACEMDTIMAL----AKKHNLFVVEDAAQGVMSTYKGRALGT 188 Query: 288 FASLPDMYERTLTVNGF--SKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSS-------- 337 + F +K + G L K ++ ++ + ++ Sbjct: 189 IGHIG--------CFSFHETKNYTAGGEGGATLINDKALIERAEIIREKGTNRSQFFRGQ 240 Query: 338 ---------GASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLGDIKGVKIS 388 G+S + A L + + + A + + L +++ Sbjct: 241 VDKYTWRDIGSSYLMSDLQAAYLWAQLEAADRINQQRLALWQNYYDALAPLAKAGRIELP 300 Query: 389 E-PQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVAMV----------PGDA 437 P G D S + FL + ++ V G+ Sbjct: 301 SIPDG--------CVQNAHMFYIKLRDIDDRSALINFLKEAEIMAVFHYIPLHGCPAGEH 352 Query: 438 FGDDS 442 FG+ Sbjct: 353 FGEFH 357 >2OGE-A nrPDB Length = 399 Score = 72.5 bits (176), Expect = 4e-13, Method: Composition-based stats. Identities = 53/313 (16%), Positives = 101/313 (32%), Gaps = 39/313 (12%) Query: 90 LAATLVQSGVPVIRLAAGEPDFDTPKVVAEAGINAIREGFTRYTLNAGITELREAICRKL 149 +++ VP + L A + A + G RY L + Sbjct: 21 MSSRAETPRVPFLDLKAAYEELRA--ETDAAIARVLDSG--RYLLGPELEGFEAEFAAYC 76 Query: 150 KEENGLSYAPDQILVSNGAKQSLLQAVLAV-CSPGDEVIIPAPYWVSYTEQARLADATPV 208 + ++ + V++G +L A+ + PGDEVI+P+ +++ ATPV Sbjct: 77 ETDHAVG-------VNSGMD-ALQLALRGLGIGPGDEVIVPSHTYIASWLAVSATGATPV 128 Query: 209 VIPTKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLL 268 + ++ LDP +E +T ++R L+ P + G L E+A L Sbjct: 129 PVE-PHEDHPTLDPLLVEKAITPRTRALL---PVHLYGHPADMDALRELADR----HGLH 180 Query: 269 VLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAAC 328 ++ D H S + K G + G + Sbjct: 181 IVEDAAQAHGARYRGRRIGAGSSVAAFSFY-----PGKNLGCFGDGGAVVTGDPELAERL 235 Query: 329 SKLQGQV--------SSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLG 380 L+ + G +S + A L + A ++ A + L Sbjct: 236 RMLRNYGSRQKYSHETKGTNSRLDEMQAAVLRIRLAHLDSWNGRRSALAAE---YLSGLA 292 Query: 381 DIKGV--KISEPQ 391 + G+ ++ P Sbjct: 293 GLPGIGLPVTAPD 305 >6BLG-A nrPDB Length = 379 Score = 72.1 bits (175), Expect = 6e-13, Method: Composition-based stats. Identities = 59/361 (16%), Positives = 116/361 (32%), Gaps = 58/361 (16%) Query: 110 DFDTPKVVAEAGINAIREGFTRYTLNAGITELREAICRKLKEENGLSYAPDQILVSNGAK 169 F+ P VV + ++ G + +++ G + A L++ Sbjct: 6 PFNAPPVVGTEL-DYMQSAMNS-GKLCGDGGFTRRCQQWMEQRFGTAKA----LLTPSCT 59 Query: 170 QSLLQAVLAV-CSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESK 228 SL A L + PGDEVI+P+ +VS L A V + + +D +E+ Sbjct: 60 ASLEMAALLLDIQPGDEVIMPSYTFVSTANAFVLRGAKIVFVDIRRDT-MNIDETLIEAA 118 Query: 229 LTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHI-IYAPATHTS 287 +T+K+R ++ P + G + IA L V+ D + Y + Sbjct: 119 ITDKTRAIV---PVHYAGVACEMDTIMAIAD----KYNLFVVEDAAQGVMSTYKGRALGT 171 Query: 288 FASLPDMYERTLTVNGF--SKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSS-------- 337 + F +K + G L + +V ++ + ++ Sbjct: 172 IGHIG--------CFSFHETKNYTAGGEGGATLINDRTLVERAEIIREKGTNRSQFFRGL 223 Query: 338 ---------GASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLGDIKGVKIS 388 G+S + A L E + + A + + L +++ Sbjct: 224 VDKYTWRDIGSSYLMSDLQAAYLWAQLEAAERINQQRLALWQNYYDALLPLARAGRIELP 283 Query: 389 EPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVAM---VP------GDAFG 439 + D I D S L + + +A+ +P G+ FG Sbjct: 284 T------VPADCGQNAHMFYIKLRDIEDRSRLIAWLKEAEILAVFHYIPLHSCPAGEQFG 337 Query: 440 D 440 + Sbjct: 338 E 338 >4WB0-B nrPDB Length = 414 Score = 72.1 bits (175), Expect = 6e-13, Method: Composition-based stats. Identities = 61/371 (16%), Positives = 116/371 (31%), Gaps = 37/371 (9%) Query: 64 LSSSVDMSLSPRVQSLKPSKTMVITDLAATLVQSGVPVIRLAAG----EPDFDTP-KVVA 118 +S+ M+ + R Q ++ I +LA + P L G E P +VV Sbjct: 3 MSTQAAMTTTERWQKIQGRAPDPIFELAKRAAAAKGPKANLVIGAYRDEQGLPYPLRVVR 62 Query: 119 EAGINAIREGFTR-YTLNAGITELREAICRKLKEENGLSYAPDQILV--SNGAKQSLLQA 175 +A + Y +G I +K G + + ++ + +L Sbjct: 63 KAEQLLLDMNLNYEYLPISGYQPF---IDEAVKMTYGDTVELENLVAVQTLSGTGALSLG 119 Query: 176 VLAVCSPGDE----VIIPAPYWVSYTEQARLADATPVVIPTKISN-NFLLDPKDLESKLT 230 + D + + P W ++ + A + + LD + ++ + Sbjct: 120 AKLLTHVFDAEKTPIYLADPTWPNHYSIVKAAGWKDIRTYAYYDHKTLGLDFEGMKKDIL 179 Query: 231 EKSR---LLILCSPSNPTGSVYPKSLLEEIARI-IAKHPRLLVLSDEIYEHIIYAPATHT 286 L+ NPTG + EIA + +AKH ++ D Y+ Sbjct: 180 AAPDGSVFLLHQCAHNPTGVDPSQEQWNEIASLMLAKHHQVFF--DSAYQGYASGSLDTD 237 Query: 287 SFAS--LPDMYERTLTVNGFSKAFAMTGWRLGYLAG-------PKHIVAACSKLQGQVSS 337 ++A+ L FSK + R G L+ + + L + Sbjct: 238 AYAARLFARRGIEVLLAQSFSKNMGLYSERAGTLSLLLKDKTKRADVKSVMDSLIRAEYT 297 Query: 338 GASSIAQKAGVAALGLGKAGGETVAE---MVKAYRERRDFLVKSLGDI--KG-VKISEPQ 391 + + L + E AE M + R R + L + G + Q Sbjct: 298 CPPAHGARLAHLILSNNELRKEWEAELSAMAERIRTMRRTVYDELLRLQTPGRWEHVINQ 357 Query: 392 GAFYLFIDFSA 402 + F+ S Sbjct: 358 IGMFSFLGLSK 368 >5VPR-A nrPDB Length = 414 Score = 70.9 bits (172), Expect = 1e-12, Method: Composition-based stats. Identities = 73/408 (17%), Positives = 135/408 (33%), Gaps = 92/408 (22%) Query: 114 PKVVAEAGINAIREGFTRYTLN--AGITEL-----------REAICRKLKEENGLSYAPD 160 PK+V +A N + Y N GI L R+ + R + ++ Sbjct: 43 PKMVLDAINNY----YEHYNANVHRGIHTLSQVATEMMEDARKKVQRFINAKHDY----- 93 Query: 161 QILVSNGAKQSLLQAVLAVCS---PGDEVIIPAPYW-------VSYTEQARLADATPVVI 210 ++L + G + + A+ DE+II + V + + A VI Sbjct: 94 EVLFTKGTTEGINLVAYAMTDLIKKDDEIII---SYLEHHSNIVPWQMLCQRTGAKLRVI 150 Query: 211 PTKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVL 270 P +D L+ L+EK++L+ + SN G V P ++EI R + + Sbjct: 151 PMNEDGTLQIDV--LDEWLSEKTKLVSVNQVSNALGIVNP---IDEIIRKVRAKSNAFIF 205 Query: 271 SDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSK 330 D + T + K + TG G L G ++ + Sbjct: 206 IDGAQAAPHFEIDVQT--------MDCDFFAFSGHKMYGPTGT--GILYGKASVLEQLNP 255 Query: 331 LQG---QVSSGASSIAQKAG-----------VAALGLGKAGGETVAEMVKAYRERRDFLV 376 G + AG +A + + ++ ++ + + Sbjct: 256 FHGGGEMIDHCTFEKTTYAGLPFRFEAGTPNIAGNIAIGTAVDFMEKVGRSNIAAHEHAL 315 Query: 377 -----KSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVA 431 + L +I+G+K+ + + F+ A G+ LDK +A Sbjct: 316 LEYAQRKLLEIEGLKVYGEKANRAGVVSFNLSGIGIASDVGM----------ILDKLGIA 365 Query: 432 MVPGDA--------FGDDSCIRISYAT-----SLDVLQAAVEKIRKAL 466 + G FG +R S+A +D+L V+K +K L Sbjct: 366 VRTGHHCTQPIMEYFGVAGTVRASFAVYNTFEEIDILTEGVKKAQKML 413 >3PD6-B nrPDB Length = 401 Score = 69.0 bits (167), Expect = 5e-12, Method: Composition-based stats. Identities = 64/388 (16%), Positives = 118/388 (30%), Gaps = 42/388 (10%) Query: 75 RVQSLKPSKTMVITDLAATLVQSGVPVIRLAAG--EPDFDTP---KVVAEAGINAIREGF 129 V+ P + +T+ + + L G D P V +A + Sbjct: 6 HVEMGPPDPILGVTEAFKR--DTNSKKMNLGVGAYRDDNGKPYVLPSVRKAEAQIAAKNL 63 Query: 130 TR-YTLNAGITELREAICRKLKEENGLSYAPD-----QILVSNGAKQSLLQAVLAVCSPG 183 + Y G+ E +A EN Q + GA + + Sbjct: 64 DKEYLPIGGLAEFCKASAELALGENNEVLKSGRFVTVQTISGTGALRVGASFLQRFFKFS 123 Query: 184 DEVIIPAPYWVSYTEQARLADATPVVI----PTKISNNFLLDPKDLESKLTEKSRLLILC 239 +V +P P W ++T R A P +F +D+ SK+ E+S LL+ Sbjct: 124 RDVFLPKPSWGNHTPIFRDAGMQLQGYRYYDPKTCGFDFSGALEDI-SKIPEQSVLLLHA 182 Query: 240 SPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFAS--LPDMYER 297 NPTG +EIA ++ K L D Y+ ++A + Sbjct: 183 CAHNPTGVDPRPEQWKEIASVVKK-KNLFAFFDMAYQGFASGDGDKDAWAVRHFIEQGIN 241 Query: 298 TLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQV-----SSGASSIAQKAGVAA-- 350 ++K + G R+G +++ Q+ ++ A +AA Sbjct: 242 VCLCQSYAKNMGLYGERVGAFTVVCKDAEEAKRVESQLKILIRPLYSNPPLNGARIAATI 301 Query: 351 LGLGKAGGETVAE---MVKAYRERRDFLVKSLGDIK---GVKISEPQGAFYLFIDFSAYY 404 L + + E M R LV +L + Q + F Sbjct: 302 LTSPDLRKQWLQEVKGMADRIISMRTQLVSNLKKEGSSHNWQHITDQIGMFCFTGLKPEQ 361 Query: 405 GSEAEGFGLINDSSSLALYFLDKFQVAM 432 + ++Y ++++ Sbjct: 362 VERL--------TKEFSVYMTKDGRISV 381 >4ZWV-A nrPDB Length = 372 Score = 68.6 bits (166), Expect = 5e-12, Method: Composition-based stats. Identities = 53/304 (17%), Positives = 97/304 (31%), Gaps = 42/304 (13%) Query: 115 KVVAEAGINAIREGFTRYTLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQ 174 + G+ + E A+ +L P + V +G L Sbjct: 14 PTALDRVAEVFASGYLGQGPR--VAEFESALAARLG-------NPRVVSVHSGTS-GLCL 63 Query: 175 AVLAVCSPG--DEVIIPAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEK 232 A+ + +P DEV+ + + + + +D DLE K++ Sbjct: 64 ALRLLDAPEERDEVLSTPLTFEATNWAILADGRRITWVDVDPAT-LTMDLDDLERKISPA 122 Query: 233 SRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLL--VLSDEIYEHIIYAPATHTSFAS 290 +R +I+ + TG L I + V+ D + S+ Sbjct: 123 TRAIIV---VHWTGYPVDLDRLAGILDRAEREHGFRPAVIEDCAHAW-------GASYRG 172 Query: 291 LPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKH-------------IVAACSKLQGQVSS 337 +P + V F +T G L P I +L+G Sbjct: 173 VPLGSHGNMCVFSFQALKHLTCGDGGLLTLPGDELHERAMLRRFYGIDRTADRLRGAYDV 232 Query: 338 GASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLGDIKGVKIS--EP--QGA 393 + +G A ETV E ++ +RE F K L + G+++ P +G+ Sbjct: 233 AEWGLKWHMTDLNAAIGLANLETVDEQLRLHRENAAFYDKELTGVPGLELLQRSPDREGS 292 Query: 394 FYLF 397 FY++ Sbjct: 293 FYVY 296 >5C6U-A nrPDB Length = 435 Score = 67.4 bits (163), Expect = 1e-11, Method: Composition-based stats. Identities = 52/366 (14%), Positives = 103/366 (28%), Gaps = 57/366 (15%) Query: 132 YTLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVC----------- 180 Y G+ LR L A ++ N + L+ ++A Sbjct: 68 YGGQHGLPGLRAIFAELL------GIAVPNLIAGNNSSLELMHDIVAFSMLYGGVDSPRP 121 Query: 181 ----SPGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLES--KLTEKSR 234 G + + P P + + + IP D +E + + Sbjct: 122 WIQEQDGIKFLCPVPGYDRHFAITETMGIEMIPIPMLQD---GPDVDLIEELVAVDPAIK 178 Query: 235 LLI-LCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYE--HIIYAPATHTSFASL 291 + + NP+G Y + + ++ P + D Y + L Sbjct: 179 GMWTVPVFGNPSGVTYSWETVRRLVQMRTAAPDFRLFWDNAYAVHTLTLDFPRQVDVLGL 238 Query: 292 PDMY---ERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGV 348 R SK G + + G +A + G+ S G + Q + Sbjct: 239 AAKAGNPNRPYVFASTSKI-TFAGGGVSFFGGSLGNIAWYLQYAGKKSIGPDKVNQLRHL 297 Query: 349 AALGLGKAGGETVAEMVKAYRERRDFLVK----SLGDIKGVKISEPQGAFYLFIDFSAYY 404 G + + + + + L + K +EP+G +++ +D Sbjct: 298 RFFGDADGVRLHMLRHQQILAPKFALVAEVLDQRLSESKIASWTEPKGGYFISLDVLPGT 357 Query: 405 GSEAEGFGLINDSSSLALYFLDKFQVAMV-PGDAF-----GDDSCIRISYATSLD-VLQA 457 +A+ G +F DD IRI+ + L+ Sbjct: 358 ARRTVA-------------LAKDVGIAVTEAGASFPYRKDPDDKNIRIAPSFPSVPDLRN 404 Query: 458 AVEKIR 463 AV+ + Sbjct: 405 AVDGLA 410 >3VK2-A nrPDB Length = 398 Score = 67.4 bits (163), Expect = 1e-11, Method: Composition-based stats. Identities = 41/221 (18%), Positives = 80/221 (36%), Gaps = 22/221 (9%) Query: 170 QSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKL 229 ++ + + PGDEV++ Y K+ + + D + LE+ + Sbjct: 91 GAITSTLWTLLRPGDEVLLGN---TLYGHTFAFLHHGIGEFGVKLRHVDMADLQALEAAM 147 Query: 230 TEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFA 289 T +R++ SP+NP + + +A+I KH V+ D Y T + Sbjct: 148 TPATRVIYFESPANPN---MHMADIAGVAKIARKH-GATVVVDNTYC---------TPYL 194 Query: 290 SLPDMYERTLTVNGFSKAFAMTG-WRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGV 348 P L V+ +K + G G + G + +V +LQG + ++ Sbjct: 195 QRPLELGADLVVHSATKYLSGHGDITAGIVVGSQALVDRI-RLQGLKDMTGAVLSPHDAA 253 Query: 349 AALGLGKAGGETVAEMVKAYRERRDFLVKSLGDIKGVKISE 389 L G +T+ + + L + L V++ Sbjct: 254 ----LLMRGIKTLNLRMDRHCANAQVLAEFLARQPQVELIH 290 >1MDZ-A nrPDB Length = 393 Score = 67.1 bits (162), Expect = 2e-11, Method: Composition-based stats. Identities = 30/148 (20%), Positives = 58/148 (39%), Gaps = 17/148 (11%) Query: 140 ELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAV-CSPGDEVIIPAPYWVSYTE 198 EL A CR + ++ + A + A++A+ GDEVI P+ WVS Sbjct: 43 ELEAAFCRLTGNQYAVAVSS--------ATAGMHIALMALGIGEGDEVITPSMTWVSTLN 94 Query: 199 QARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIA 258 L A PV++ ++ P+ +E+ +T +++ +I P + G+ + + Sbjct: 95 MIVLLGANPVMVDVDRDT-LMVTPEHIEAAITPQTKAII---PVHYAGAPADLDAIYALG 150 Query: 259 RIIAKHPRLLVLSDEIYEHIIYAPATHT 286 + V+ D + H Sbjct: 151 ER----YGIPVIEDAAHATGTSYKGRHI 174 >2HOR-A nrPDB Length = 427 Score = 66.7 bits (161), Expect = 2e-11, Method: Composition-based stats. Identities = 55/352 (15%), Positives = 108/352 (30%), Gaps = 50/352 (14%) Query: 140 ELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVC--------SPGDEVIIPAP 191 EL + I + + I+ G Q + V+++ +P +V+ AP Sbjct: 104 ELEKTIKELHEVVGNAAAKDRYIVFGVGVTQLIHGLVISLSPNMTATPDAPESKVVAHAP 163 Query: 192 YWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPK 251 ++ + EQ + D V +N + + + ++ SP+NP G + Sbjct: 164 FYPVFREQTKYFDKKGYVWAGNAANYV--------NVSNPEQYIEMVTSPNNPEGLL--- 212 Query: 252 SLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMT 311 + + + D +Y Y P + + + + + SK + Sbjct: 213 --RHAVIKGCKS------IYDMVYYWPHYTPIKYKA--------DEDILLFTMSKFTGHS 256 Query: 312 GWRLGYLAG-PKHIVAACSKLQGQVSSGASSIAQ-------KAGVAALGLGKAGGETVAE 363 G R G+ + + + + G Q K VA + K + Sbjct: 257 GSRFGWALIKDESVYNNLLNYMTKNTEGTPRETQLRSLKVLKEVVAMVKTQKGTMRDLNT 316 Query: 364 M-VKAYRERRDFLVKSLGDIKGVKISE-PQGAF--YLFIDFSAYYGSEAEGFGLINDSSS 419 K RER + L E PQ + Y F S A + Sbjct: 317 FGFKKLRERWVNITALLDQSDRFSYQELPQSEYCNY-FRRMRPPSPSYAWVKCEWEEDKD 375 Query: 420 LALYFLDKFQVAMVPGDAFGDDS-CIRISYATSLDVLQAAVEKIRKALEPLR 470 ++ G F S +R+S + D + ++ ++ R Sbjct: 376 -CYQTFQNGRINTQNGVGFEASSRYVRLSLIKTQDDFDQLMYYLKDMVKAKR 426 >4RKC-A nrPDB Length = 398 Score = 64.7 bits (156), Expect = 8e-11, Method: Composition-based stats. Identities = 54/361 (14%), Positives = 114/361 (31%), Gaps = 42/361 (11%) Query: 102 IRLAAGE--------PDFDTPKVVAEAGINAIREGFTRYTLNAGITELREAICRKLKEEN 153 + L G P D K+ + + I Y AG+ R+ L ++ Sbjct: 29 VNLGIGIYYDESGVMPVLDCVKIAEQRIADPISPRP--YLPMAGLPGHRKGCQELLFGKD 86 Query: 154 GLSYAPDQI--LVSNGAKQSLLQAVLAVCS---PGDEVIIPAPYWVSYTEQARLADATPV 208 + + + G +L + P + + P W ++ D Sbjct: 87 APVLKDGLVATIATIGGSGAL-KVGAEFIHEWFPQSKCYVSDPTWGNHIAIFEGCDIEVG 145 Query: 209 VIPTKISNNFLLDPKDLESKL-TEKSRLLILCSP--SNPTGSVYPKSLLEEIARIIAKHP 265 P + + ++ + T ++L P NPTG + + + +I + Sbjct: 146 KYPYYDTATGGIKFDEMIAFFETLNKDDVLLLHPCCHNPTGVDLTREQWDTVLNVIQERE 205 Query: 266 RLLVLSDEIYEHIIYA-PATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHI 324 + + D Y+ + + DM N FSK ++ G R+G L+ Sbjct: 206 LIPFM-DIAYQGFGEDMDSDAYAIRKAVDMGLPLFVSNSFSKNLSLYGERVGGLSVVCPT 264 Query: 325 VAACSKLQGQVSSGA----SSIAQKAGV--------AALGLGKAGGET-VAEMVKAYRER 371 V ++ GQ++S SS G AAL G + + +K+ R + Sbjct: 265 VDETERVFGQLNSTVRRIYSSPPSHGGRVVDIVMNDAALHEQWVGEVYAMRDRIKSMRTK 324 Query: 372 RDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVA 431 ++++ + Q + F + + +Y + ++ Sbjct: 325 LKSVLEAKISGRNFDYLTAQNGMFSFTGLTPEQVERLQS--------EFGIYMISNSRMC 376 Query: 432 M 432 + Sbjct: 377 V 377 >1M6S-A nrPDB Length = 347 Score = 63.6 bits (153), Expect = 2e-10, Method: Composition-based stats. Identities = 66/376 (17%), Positives = 119/376 (31%), Gaps = 56/376 (14%) Query: 108 EPDFDTPKVVAEAGINAIREGFTRYTLNAGITELREAICRKLKEENGLSYAPDQILVSNG 167 + + + +A A G Y + I EL + + L Sbjct: 11 DTVTKPTEEMRKAMAQA-EVGDDVYGEDPTINELERLAAETFGK--------EAALFVPS 61 Query: 168 AKQSLLQAVLAVCSPGDEVIIPAP---YWVSYTEQARLADATPVVIPTKISNNFLLDPKD 224 +++A GDEVI+ A +W A L+ P +P K N +DP D Sbjct: 62 GTMGNQVSIMAHTQRGDEVILEADSHIFWYEVGAMAVLSGVMPHPVPGK---NGAMDPDD 118 Query: 225 LESKLT------EKSRLLILCSPSNPT-GSVYPKSLLEEIARIIAKHPRLLVLSDEIYEH 277 + + ++ L+ + + N + G V P ++EI I +H + V D Sbjct: 119 VRKAIRPRNIHFPRTSLIAIENTHNRSGGRVVPLENIKEICTIAKEH-GINVHIDGA-RI 176 Query: 278 IIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSS 337 + A+ + + SK + + G + + K + + Sbjct: 177 FNASIASGVPVKEYAGYADSVMFC--LSK--GLCAPVGSVVVGDRDFIERARKARKMLGG 232 Query: 338 GASSIAQKAGVAALGLGKAGGETVAEMVKAYR---ERRDFLVKSLGDIKGVKISEPQGAF 394 G Q +AA AG + +MV + E FL L +I G ++ P+ Sbjct: 233 GM---RQAGVLAA-----AGIIALTKMVDRLKEDHENARFLALKLKEI-GYSVN-PE--- 279 Query: 395 YLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVAMVPGDAFGDDSCIRISYAT--SL 452 D +N + L V D+ IR+ S Sbjct: 280 ----DVKTNMVILRTDNLKVNAHGFIEA--LRNSGVLANAVS----DTEIRLVTHKDVSR 329 Query: 453 DVLQAAVEKIRKALEP 468 + ++ A+ K Sbjct: 330 NDIEEALNIFEKLFRK 345 >1B9H-A nrPDB Length = 388 Score = 63.6 bits (153), Expect = 2e-10, Method: Composition-based stats. Identities = 27/115 (23%), Positives = 57/115 (49%), Gaps = 10/115 (8%) Query: 164 VSNGAKQSLLQAVLAV-CSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNNFLLDP 222 V+NG +L A+ + PG EVI+PA ++S ++ A+ A V + + + LDP Sbjct: 59 VTNG-THALELALQVMGVGPGTEVIVPAFTFISSSQAAQRLGAVTVPVDVDAAT-YNLDP 116 Query: 223 KDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEH 277 + + + +T ++++++ P + G + L +I + + +L D + H Sbjct: 117 EAVAAAVTPRTKVIM---PVHMAGLMADMDALAKI----SADTGVPLLQDAAHAH 164 >1TAR-A nrPDB Length = 401 Score = 63.6 bits (153), Expect = 2e-10, Method: Composition-based stats. Identities = 68/391 (17%), Positives = 123/391 (31%), Gaps = 38/391 (9%) Query: 66 SSVDMSLSPRVQSLKPSKTMVITDLAATLVQSGVPVIRLAAGEPDFDTPKVVAEAGINAI 125 S V+M + + + L GV R G+P AEA I A Sbjct: 5 SHVEMGPPDPILGVTEAFKRDTNSKKMNL---GVGAYRDDNGKPYVLNCVRKAEAMIAA- 60 Query: 126 REGFTRYTLNAGITELREAICRKLKEENGLSYAPDQILV-----SNGAKQSLLQAVLAVC 180 ++ Y AG+ + A EN ++ + + G+ + + Sbjct: 61 KKMDKEYLPIAGLADFTRASAELALGENSEAFKSGRYVTVQGISGTGSLRVGANFLQRFF 120 Query: 181 SPGDEVIIPAPYWVSYTEQARLADATPVVI----PTKISNNFLLDPKDLESKLTEKSRLL 236 +V +P P W ++T R A P S +F +D+ SK+ EKS +L Sbjct: 121 KFSRDVYLPKPSWGNHTPIFRDAGLQLQAYRYYDPKTCSLDFTGAMEDI-SKIPEKSIIL 179 Query: 237 ILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFA--SLPDM 294 + NPTG + +E+A ++ K LL D Y+ ++A + Sbjct: 180 LHACAHNPTGVDPRQEQWKELASVVKKR-NLLAYFDMAYQGFASGDINRDAWALRHFIEQ 238 Query: 295 YERTLTVNGFSKAFAMTGWRLGYLAG-------PKHIVAACSKLQGQVSSGASSIAQKAG 347 + ++K + G R G K + + L + S + Sbjct: 239 GIDVVLSQSYAKNMGLYGERAGAFTVICRDAEEAKRVESQLKILIRPMYSNPPMNGARIA 298 Query: 348 VAALGLGKAGGETVAE---MVKAYRERRDFLVKSLGDIK---GVKISEPQGAFYLFIDFS 401 L + E + E M R LV +L + Q + F Sbjct: 299 SLILNTPELRKEWLVEVKGMADRIISMRTQLVSNLKKEGSSHNWQHITDQIGMFCFTGLK 358 Query: 402 AYYGSEAEGFGLINDSSSLALYFLDKFQVAM 432 + ++Y ++++ Sbjct: 359 PEQVERL--------TKEFSIYMTKDGRISV 381 >5XT5-A nrPDB Length = 419 Score = 63.6 bits (153), Expect = 2e-10, Method: Composition-based stats. Identities = 63/405 (15%), Positives = 131/405 (32%), Gaps = 93/405 (22%) Query: 119 EAGINAIREGFTRYTLN-------------AGITELREAICRKLKEENGLSYAPDQILVS 165 A I + + + +Y N G RE + + + ++ +I+ + Sbjct: 38 RAVIETLDKYYNQYNSNVHRGVHTLGTRATDGYEGAREKVRKFINAKSMA-----EIIFT 92 Query: 166 NGAKQSLLQAV----LAVCSPGDEVIIPAPYW-------VSYTEQARLADATPVVIPTKI 214 G SL A PGDEV+I + + + + + AT IP + Sbjct: 93 KGTTTSLNMVALSYARANLKPGDEVVI---TYMEHHANIIPWQQAVKATGATLKYIPLQE 149 Query: 215 SNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEI 274 + + +D+ +T ++++ + SN G+V P + +IA +++ D Sbjct: 150 --DGTISLEDVRETVTSNTKIVAVSHVSNVLGTVNPIKEMAKIAH----DNGAVIVVDGA 203 Query: 275 YEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAA------- 327 + K TG +G L G K ++ Sbjct: 204 QST--------PHMKIDVQDLDCDFFALSSHKMCGPTG--VGVLYGKKALLENMEPAEFG 253 Query: 328 -------------CSKLQGQVSSGASSIAQKAGV-AALGLGKAGGETVAEMVKAYRERRD 373 +L + +G IA G+ AA+ + G + E+ + + Sbjct: 254 GEMIDFVGLYESTWKELPWKFEAGTPIIAGAIGLGAAIDFLEEIG--LDEISRHEHKLAA 311 Query: 374 FLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVAMV 433 + ++ + GV + P+ + F L + LD +A+ Sbjct: 312 YALERFRQLDGVTVYGPE------------ERAGLVTFNLDDVHPHDVATVLDAEGIAVR 359 Query: 434 PGDAFGDD--------SCIRISYATSLDVLQAAVEKIRKALEPLR 470 G + R S+ L + ++K+ +AL+ + Sbjct: 360 AGHHCAQPLMKWLDVTATARASFY--LYNTEEEIDKLVEALQKTK 402 >4H51-A nrPDB Length = 420 Score = 63.2 bits (152), Expect = 2e-10, Method: Composition-based stats. Identities = 58/373 (15%), Positives = 113/373 (30%), Gaps = 37/373 (9%) Query: 64 LSSSVDMSLSPRVQSLKPSKTMVITDLAATLVQSGVPVIRLAAG----EPDFDTPKVVAE 119 +S+ M+ + R Q ++ VI DLA + P L G E P V Sbjct: 9 MSTQAAMTTAERWQKIQAQAPDVIFDLAKRAAAAKGPKANLVIGAYRDEQGRPYPLRVVR 68 Query: 120 AGINAIREGFTRYT--LNAGITELREAICRKLKEENGLSYAPDQILV--SNGAKQSLLQA 175 + + Y +G I +K G + + ++ + ++ Sbjct: 69 KAEQLLLDMNLDYEYLPISGYQPF---IDEAVKIIYGNTVELENLVAVQTLSGTGAVSLG 125 Query: 176 VLAVCSPGDE----VIIPAPYWVSYTEQARLADATPVVIPTKISN-NFLLDPKDLESKLT 230 + D + + P W ++ + A + L+ + ++ + Sbjct: 126 AKLLTRVFDAETTPIYLSDPTWPNHYGVVKAAGWKNICTYAYYDPKTVSLNFEGMKKDIL 185 Query: 231 EKSRLLILCS---PSNPTGSVYPKSLLEEIARI-IAKHPRLLVLSDEIYEHIIYAPATHT 286 + NPTG + EIA + +AKH ++ D Y+ Sbjct: 186 AAPDGSVFILHQCAHNPTGVDPSQEQWNEIASLMLAKHHQVFF--DSAYQGYASGSLDTD 243 Query: 287 SFAS--LPDMYERTLTVNGFSKAFAMTGWRLGYLAG-------PKHIVAACSKLQGQVSS 337 ++A+ L FSK + R G L+ + + L + + Sbjct: 244 AYAARLFARRGIEVLLAQSFSKNMGLYSERAGTLSLLLKDKTKRADVKSVMDSLIREEYT 303 Query: 338 GASSIAQKAGVAALGLGKAGGETVAE---MVKAYRERRDFLVKSLGDI--KG-VKISEPQ 391 + + L + E AE M + R R + L + G + Q Sbjct: 304 CPPAHGARLAHLILSNNELRKEWEAELSAMAERIRTMRRTVYDELLRLQTPGSWEHVINQ 363 Query: 392 GAFYLFIDFSAYY 404 + F+ S Sbjct: 364 IGMFSFLGLSKAQ 376 >1T3I-A nrPDB Length = 420 Score = 63.2 bits (152), Expect = 3e-10, Method: Composition-based stats. Identities = 64/407 (15%), Positives = 129/407 (31%), Gaps = 84/407 (20%) Query: 114 PKVVAEAGINA-------IREGFTRYT--LNAGITELREAICRKLKEENGLSYAPDQILV 164 P+ V E ++ + G + + +R + + + +P +I+ Sbjct: 41 PRAVLEKLMHYYENDNANVHRGAHQLSVRATDAYEAVRNKVAKFINAR-----SPREIVY 95 Query: 165 SNGAKQSLLQAVLAV----CSPGDEVII----PAPYWVSYTEQARLADATPVVIPTKISN 216 + A +++ + GDE+I V + A A + Sbjct: 96 TRNATEAINLVAYSWGMNNLKAGDEIITTVMEHHSNLVPWQMVAAKTGAVLKFVQLDEQE 155 Query: 217 NFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYE 276 +F D + ++ L+EK++L+ + SN G V P + ++A VL D Sbjct: 156 SF--DLEHFKTLLSEKTKLVTVVHISNTLGCVNPAEEIAQLAHQA----GAKVLVDACQS 209 Query: 277 HIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQG--- 333 Y + + V K A TG +G+L G + I+ A G Sbjct: 210 APHYPLD--------VQLIDCDWLVASGHKMCAPTG--IGFLYGKEEILEAMPPFFGGGE 259 Query: 334 -----------------QVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLV 376 + +G +IA+ + A + + E +L Sbjct: 260 MIAEVFFDHFTTGELPHKFEAGTPAIAEAIALGAAVDYLTDLG-MENIHNYEVELTHYLW 318 Query: 377 KSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVAMVPGD 436 + LG I +++ P + F + +S +D+ +A+ G Sbjct: 319 QGLGQIPQLRLYGPN--------PKHGDRAALASFNVAGLHASDVATMVDQDGIAIRSGH 370 Query: 437 A--------FGDDSCIRIS--YATSLDVLQAAVEKIRKALEPLRATV 473 F R S + + + + L+ L+AT+ Sbjct: 371 HCTQPLHRLFDASGSARASLYFYNTKEEIDL-------FLQSLQATI 410 >5W70-A nrPDB Length = 445 Score = 63.2 bits (152), Expect = 3e-10, Method: Composition-based stats. Identities = 45/267 (16%), Positives = 84/267 (31%), Gaps = 26/267 (9%) Query: 117 VAEAGINAIREG-FTRYTLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQA 175 V +A + + G ++ G R NG+ + + SL+ A Sbjct: 49 VPDAVADVLGSGRWSISGPYRGTESYERRFARAFAAYNGVP----HCVPAASGTASLMLA 104 Query: 176 VLAV-CSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSR 234 + A GDEVI+P WV+ +A P+ L P+ +E+ +TE +R Sbjct: 105 LEACGIGAGDEVIVPGLSWVASGSTILGVNAVPIFCDVDPDT-LCLSPEAVEAAITEHTR 163 Query: 235 LLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEH-IIYAPATHTSFASLPD 293 +++ + ++ L I A+ L ++ D H Y + A+ Sbjct: 164 AIVV---VHLYSALADMDALSAI----AERHGLPLIEDCAQAHGATYRGVKVGALATAG- 215 Query: 294 MYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGL 353 + +T G + A + S++ G L Sbjct: 216 -------TFSMQHSKVLTSGEGGAVITRDEDFARRVEHLRADGRCLSAVPPAPGAMELV- 267 Query: 354 GKAGGETVAEMVKAYRERRDFLVKSLG 380 GE + + L + L Sbjct: 268 --ETGELMGNNRCLSEFQAAILAEQLT 292 >4EFF-A nrPDB Length = 420 Score = 61.7 bits (148), Expect = 6e-10, Method: Composition-based stats. Identities = 60/353 (16%), Positives = 115/353 (32%), Gaps = 30/353 (8%) Query: 70 MSLSPRVQSLKPSKTMVITDLAATLVQSGVPVIRLAAG---EPDFDTP--KVVAEAGINA 124 MSL V+ + + + A V L G D P + V +A Sbjct: 22 MSLFSAVELAPRDPILGLNE-AFNADTRPTKV-NLGVGVYTNEDGKIPLLRAVRDAEKAR 79 Query: 125 IREGF-TRYTLNAGITELREAICRKLKEENGLSYAPDQILV--SNGAKQSLLQA--VLAV 179 + G Y GI ++ + L ++ A +++ + G +L L Sbjct: 80 VEAGLPRGYLPIDGIAAYDASVQKLLLGDDSPLIAAGRVVTAQALGGTGALKIGADFLRT 139 Query: 180 CSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLT---EKSRLL 236 +P +V I P W ++ +A V P + ++ + + L + ++ Sbjct: 140 LNPKAKVAISDPSWENHRALFDMAGFEVVAYPYYDAKTNGVNFDGMLAALNGYEPGTIVV 199 Query: 237 ILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHI-IYAPATHTSFASLPDMY 295 + NPTG + ++ ++ + L D Y+ A + Sbjct: 200 LHACCHNPTGVDLNDAQWAQVVEVVKARRLVPFL-DIAYQGFGESIEADAAAVRLFAAAN 258 Query: 296 ERTLTVNGFSKAFAMTGWRLGYLAG----PKHIVAACSKLQGQVSSGASSIAQKAG---V 348 + FSK+F++ G R+G L+ S+L+ + + S+ G Sbjct: 259 LNVFVSSSFSKSFSLYGERVGALSIITDSKDEAARVLSQLKRVIRTNYSNPPTHGGAIVA 318 Query: 349 AALGLGKAGGET---VAEMVKAYRERRDFLVKSLGDIK---GVKISEPQGAFY 395 A L + + EM R R+ LV+ L Q + Sbjct: 319 AVLASPELRASWVQELGEMRDRIRAMRNGLVERLKAAGIERDFSFINAQRGMF 371 >5U24-A nrPDB Length = 382 Score = 61.3 bits (147), Expect = 9e-10, Method: Composition-based stats. Identities = 26/117 (22%), Positives = 54/117 (46%), Gaps = 10/117 (8%) Query: 162 ILVSNGAKQSLLQAVLAV-CSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNNFLL 220 I V+NG +L + A DE+I+PA +++ P++I I N + + Sbjct: 75 IGVANGLD-ALRLIIKAYDFKENDEIIVPANTYIASILAITDNKCKPILIEPDI-NTYNI 132 Query: 221 DPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEH 277 +P +E K+T+K++ +++ + G V + +++A L ++ D H Sbjct: 133 NPDLIEEKITKKTKAIMV---VHLYGQVCDMEKI----QLLANKYNLKIIEDCAQAH 182 >3II0-A nrPDB Length = 422 Score = 60.9 bits (146), Expect = 1e-09, Method: Composition-based stats. Identities = 61/398 (15%), Positives = 124/398 (31%), Gaps = 48/398 (12%) Query: 102 IRLAAGEPDFDTPKVVAEAGINAIREGF-------TRYTLNAGITELREAICRKLKEENG 154 + L G D + + + Y G+ E R R ++ Sbjct: 22 VNLGVGAYRTDDCHPWVLPVVKKVEQKIANDNSLNHEYLPILGLAEFRSCASRLALGDDS 81 Query: 155 LSYAPDQI--LVSNGAKQSLLQAVLAVC-------SPGDEVIIPAPYWVSYTEQARLADA 205 + ++ + S G +L + + V + +P W ++ A Sbjct: 82 PALKEKRVGGVQSLGGTGALRIGADFLARWYNGTNNKNTPVYVSSPTWENHNAVFSAAGF 141 Query: 206 TPVVIPTKISNNF-----LLDPKDLESKLTEKSRLLILCS---PSNPTGSVYPKSLLEEI 257 + + LD + + L I+ NPTG ++I Sbjct: 142 K----DIRSYRYWDAEKRGLDLQGFLNDLENAPEFSIVVLHACAHNPTGIDPTPEQWKQI 197 Query: 258 ARIIAKHPRLLVLSDEIYEHIIYAPATHTSFAS---LPDMYERTLTVNGFSKAFAMTGWR 314 A + KH L D Y+ ++A + + +E FSK F + R Sbjct: 198 AS-VMKHRFLFPFFDSAYQGFASGNLERDAWAIRYFVSEGFEF-FCAQSFSKNFGLYNER 255 Query: 315 LGYLAG----PKHIVAACSKLQGQVSSG-ASSIAQKAGVAALGLGKAGGETVAEMVKAYR 369 +G L P+ I+ S+++ V ++ AQ A + A L E E + Sbjct: 256 VGNLTVVGKEPESILQVLSQMEKIVRITWSNPPAQGARIVASTLSN--PELFEEWTGNVK 313 Query: 370 ERRDFLVKSLGDIKG-VKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKF 428 D ++ +++ ++ + G + + G F + Y +++ Sbjct: 314 TMADRILTMRSELRARLEALKTPGT---WNHITDQIGM----FSFTGLNPKQVEYLVNEK 366 Query: 429 QVAMVPGDAFGDDSCIRISYATSLDVLQAAVEKIRKAL 466 + ++P + + AV KI + L Sbjct: 367 HIYLLPSGRINVSGLTTKNLDYVATSIHEAVTKIAENL 404 >3MEB-A nrPDB Length = 448 Score = 60.5 bits (145), Expect = 1e-09, Method: Composition-based stats. Identities = 67/366 (18%), Positives = 122/366 (33%), Gaps = 36/366 (9%) Query: 98 GVPVIRLAAGEPDFDTPKVVAEAGINAIREGFTR-YTLNAGITELREAICRKLKEENGLS 156 GV R +G+P AEA I++ + + Y AG EA + ++ + Sbjct: 55 GVGAYRDESGKPWILPAVKEAEAIISSDLSKYNKEYPPVAGFPLFLEAAQFLMFGKDSKA 114 Query: 157 YAPDQI-----LVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVS-YTEQARLADATPVVI 210 +I L G+ + L + P E +P+ W + Y ++ + V Sbjct: 115 AQEGRIASCQSLSGTGSLH-IGFEFLHLWMPKAEFYMPSTTWPNHYGIYDKVFNKLKVPY 173 Query: 211 P----TKISNNFLLDPKDLESKLT---EKSRLLILCSPSNPTGSVYPKSLLEEIARIIAK 263 + +D + + + EKS L NP+G + ++ +E+ I+ + Sbjct: 174 KEYTYLRKDGELEIDFSNTKKDIQSAPEKSIFLFHACAHNPSGIDFTEAQWKELLPIMKE 233 Query: 264 HPRLLVLSDEIYEHIIYAPATHTSFAS--LPDMYERTLTVNGFSKAFAMTGWRLGYLAG- 320 + D Y+ +FA D L FSK F + G R+G L Sbjct: 234 KKHIAFF-DSAYQGFATGSFEADAFAVRMFVDAGVEVLVAQSFSKNFGLYGERIGCLHVV 292 Query: 321 ----------PKHIVAAC---SKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKA 367 K + AA LQ + + S+I V + K + + VK Sbjct: 293 HAGVEGSVEKNKALSAAMVSGMTLQIRKTWSMSAIHGAYIVQVIVHDKRLLQMFYDNVKE 352 Query: 368 YRERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDK 427 R + L + + G+ + G F + Y +K Sbjct: 353 MSARIHRMRSLLHASLAKRKTPGPGSKGTWDHILTAIGM----FTFTGLTPEHVDYLKEK 408 Query: 428 FQVAMV 433 + + +V Sbjct: 409 WSIYLV 414 >5K8B-A nrPDB Length = 403 Score = 60.5 bits (145), Expect = 1e-09, Method: Composition-based stats. Identities = 48/249 (19%), Positives = 89/249 (35%), Gaps = 39/249 (15%) Query: 163 LVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNNFLLDP 222 L+S+G + A GDEVI+P +V+ E +A A P+ +I L P Sbjct: 57 LLSSGTAALQTAMMAAGIGAGDEVIVPPFTFVASVEAIFMAGAVPIF--AEIDETLCLSP 114 Query: 223 KDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAP 282 + +E+ +T +++ + N + ++EI I KH L++L D I Sbjct: 115 EGIEAVITPRTKAI------NLVHMCGSMAKMDEIKAICKKH-NLVLLEDACQA--IGGS 165 Query: 283 ATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSI 342 + ++ D + F +T G + G I Sbjct: 166 YKGQALGTIGD-----VGCYSFDSVKTITCGEGGAVITNN--TEIYDNAHMFSDHGHDHI 218 Query: 343 AQKAGV----------------AALGLGKAGGETVAEMVKAYRERRDFLVKSLGDIKGV- 385 + G AALGL + + ++ R+ + + ++ I V Sbjct: 219 GKDRGAESHPIMGLNFRISEMNAALGLAQLRK--LDTIIDIQRKNKKAIKDAMASIPEVS 276 Query: 386 --KISEPQG 392 +I +P+G Sbjct: 277 FREIPDPEG 285 >2GMS-A nrPDB Length = 390 Score = 60.5 bits (145), Expect = 2e-09, Method: Composition-based stats. Identities = 44/301 (14%), Positives = 95/301 (31%), Gaps = 44/301 (14%) Query: 149 LKEENGLSYAPDQILVSNGAKQSLLQAVLAV------CSPGDEVIIPAPYWVSYTEQARL 202 + G YA ++VS+G+ +LL GDE+I+PA W + + Sbjct: 43 FAKTFGSKYA---VMVSSGSTANLLMIAALFFTKKPRLKKGDEIIVPAVSWSTTYYPLQQ 99 Query: 203 ADATPVVIPTKISNNFLLDPKDLESKLTEKSRLL----ILCSPSNPTGSVYPKSLLEEIA 258 + I N +D + L+ +T+ ++ + +L +P+N +EI Sbjct: 100 YGLRVKFVDIDI-NTLNIDIESLKEAVTDSTKAILTVNLLGNPNN----------FDEIN 148 Query: 259 RIIAKHPRLLVLSDEIYE-HIIYAPATHTSFASLPDMYERTLTVNGFSKAFA--MTGWRL 315 +II +++L D + +F + FS ++ + Sbjct: 149 KIIGGR-DIILLEDNCESMGATFNNKCAGTFG----------LMGTFSSFYSHHIATMEG 197 Query: 316 GYLAGPKHIVAA---CSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAE--MVKAYRE 370 G + + C + G + + GV + + + V V+ Sbjct: 198 GCIVTDDEEIYHILLCIRAHG-WTRNLPKKNKVTGVKSDDQFEESFKFVLPGYNVRPLEM 256 Query: 371 RRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQV 430 ++ L + + A Y F + + + + + V Sbjct: 257 SGAIGIEQLKKLPRFISVRRKNAEYFLDKFKDHPYLDVQQETGESSWFGFSFIIKKDSGV 316 Query: 431 A 431 Sbjct: 317 I 317 >1PFF-A nrPDB Length = 331 Score = 59.7 bits (143), Expect = 2e-09, Method: Composition-based stats. Identities = 44/276 (15%), Positives = 87/276 (31%), Gaps = 34/276 (12%) Query: 159 PDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVS----YTEQARLADATPVVIPTKI 214 + + ++ +V GD +I + + Q R I + Sbjct: 13 AEACAATASGMGAIAASVWTFLKAGDHLISDDCLYGCTHALFEHQLRKFGVEVDFIDMAV 72 Query: 215 SNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEI 274 N +E L +R++ +P+NPT V +E+ + K +LV+ D Sbjct: 73 PGN-------IEKHLKPNTRIVYFETPANPTLKVID---IEDAVKQARKQKDILVIVDNT 122 Query: 275 YEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAM-TGWRLGYLAGPKHIVAACSKLQG 333 + + + P + V+ +K T G + I+A Sbjct: 123 FA---------SPILTNPLDLGVDIVVHSATKYINGHTDVVAGLVCSRADIIAKVKSQGI 173 Query: 334 QVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLGDIKGVKISEPQGA 393 + +GA A L G T+ VK E + + L + K VK Sbjct: 174 KDITGAIISPHDA-----WLITRGTLTLDMRVKRAAENAQKVAEFLHEHKAVKKV----- 223 Query: 394 FYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQ 429 +Y + + + + + + L+K + Sbjct: 224 YYPGLPDHPGHEIAKKQMKMFGSMIAFDVDGLEKAK 259 >6EZL-A nrPDB Length = 404 Score = 59.4 bits (142), Expect = 3e-09, Method: Composition-based stats. Identities = 64/383 (16%), Positives = 111/383 (28%), Gaps = 42/383 (10%) Query: 76 VQSLKPSKTMVITDLAATLVQSGVPVIRLAAGEPD-FDTPKVVAEAGINAIRE--GFTRY 132 + +L + +A + +I A + + P V + E Y Sbjct: 10 IAALPADPIFSASLVAKKAPEPKADLIIGAYRDAEGHPYPLNVVRKAEQRLLEMNADKEY 69 Query: 133 TLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQ----SLLQAVLA-VCSPGDEVI 187 +G I LK G S A + ++ G S+ LA V S V Sbjct: 70 LPMSGYAPF---IEESLKIAYGDSVARENVVGIQGLSGTGSLSIGACFLARVLSRDTPVY 126 Query: 188 IPAPYWVSYTEQARLADATPVVIPTKISNNFL-LDPKDLESKLT---EKSRLLILCSPSN 243 I P W ++ A+ T + N +D L L E S +++ N Sbjct: 127 ISDPTWPNHYAVMAAANLTDLRKYRYYDNAKRCIDFDGLLEDLNGAPEGSIVILHACAHN 186 Query: 244 PTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYA--PATHTSFASLPDMYERTLTV 301 PTG +I + + D Y+ S L Sbjct: 187 PTGMDPTHEQWAKILEVFQARRLIPFF-DSAYQGYATGSLDNDAYSIRLFARQGMEMLLA 245 Query: 302 NGFSKAFAMTGWRLG----YLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAG 357 +SK + R+G A PK S+L+ V S S+ A + Sbjct: 246 QSYSKNMGLYAERVGVCSIVTANPKKAPLIKSQLETIVRSQYSTPPAHGARVAYLVLSDP 305 Query: 358 ------GETVAEMVKAYRERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGF 411 + + M E R L L + G + + F Sbjct: 306 ELRAGWEQELRVMSTRVLEMRQALYDGLKRL---------GTPGSWEHI----IQQVGMF 352 Query: 412 GLINDSSSLALYFLDKFQVAMVP 434 + + + +++ +V ++P Sbjct: 353 SYLGLTKAQCEKLIER-RVFVLP 374 >2X8U-A nrPDB Length = 412 Score = 59.0 bits (141), Expect = 4e-09, Method: Composition-based stats. Identities = 53/285 (18%), Positives = 88/285 (30%), Gaps = 30/285 (10%) Query: 109 PDFDTPKVVAEAGINAIREGFTRYTLN-------AGITELREAICRKLKEENGLSYAPDQ 161 FD V AG A+ E + T + G +A+ E+ Sbjct: 57 MTFDPD--VIAAGKQALDEFGSGTTGSRVLNGTYQGHKACEDALKEFYGTEHA------- 107 Query: 162 ILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNNFLLD 221 I+ S G Q+ L + + GD +I+ A S + L DA V + Sbjct: 108 IVFSTG-YQANLGMISTLAGKGDYIILDADSHASIYDGCWLGDAEIVRFRHNSVEDL--- 163 Query: 222 PKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYA 281 K L E +L++L + G + P + + +K ++L DE + + Sbjct: 164 DKRLGRLPAEAGKLVVLEGVYSMMGDIAPLQEMVAV----SKKHGAMILVDEAHGMGFFG 219 Query: 282 PATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASS 341 F + V FSK+ G G+ + AS Sbjct: 220 EHGRGVFEEAGVEADVDFVVGTFSKSVGTVG---GFCVSNHPKFEVLRLVCRPYVFTASL 276 Query: 342 IAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLGDIKGVK 386 AA + K + + L + L D+ G K Sbjct: 277 PPSVVATAATSIRKLM--HAGDKRAHLWKNSRRLHQGLRDM-GYK 318 >6ONN-A nrPDB Length = 402 Score = 58.6 bits (140), Expect = 6e-09, Method: Composition-based stats. Identities = 59/368 (16%), Positives = 120/368 (32%), Gaps = 56/368 (15%) Query: 121 GINAIREGFTRYTLN-----------AGITELREAICRKLKEENGLSYAPDQILVSNGAK 169 + AI EG RY +L + + G P + S G Sbjct: 66 LVAAITEGARRYGAGSGGSHLLGGHSRAHAQLEDDLAEFAG---GFVDNPRALYFSTG-Y 121 Query: 170 QSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKL 229 + L + A+ G + + S + ARL+ A + P D + L + L Sbjct: 122 MANLATLTALAGRGTTLFSDSLNHASLIDGARLSRADIQIYP-------HADAEALGAML 174 Query: 230 TEKSRLLILCSPSNPTGSVYPKS-LLEEIARII--AKHPRLLVLSDEIYEHIIYAPATHT 286 + L + +V+ + +AR++ A+H ++ D+ + + P Sbjct: 175 EASDAAVKLIV----SDTVFSMDGDIAPLARLLELAEHHGAWLVVDDAHGFGVLGPQGRG 230 Query: 287 SFASLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVA-ACSKLQGQVSSGASSIAQK 345 + A + V KA ++G ++ + ++ + + + + AS + Sbjct: 231 AVAEAALRSPHLIVVGTLGKAAGVSG---AFVVAHETVIEWLVQRARPYIFTTASVPSAA 287 Query: 346 AGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYG 405 V+A L GG+ R L ++ ++ Sbjct: 288 HAVSA-SLRIIGGDEGEHRRAHLRSLIALTRDMLKSTP-------------WLPVDSHTA 333 Query: 406 SEAEGFGLINDSSSLALYFLDKFQV---AMVPGDAFGDDSCIRISYA-----TSLDVLQA 457 + G + +A D+ + A+ P S +RIS + L+ L+ Sbjct: 334 VQPLIIGSNEATLDVAASL-DRANLWVPAIRPPTVPEGTSRLRISLSAAHSHNDLEQLEH 392 Query: 458 AVEKIRKA 465 A+ K +A Sbjct: 393 ALMKTAEA 400 >6C9E-A nrPDB Length = 422 Score = 57.8 bits (138), Expect = 9e-09, Method: Composition-based stats. Identities = 71/422 (16%), Positives = 143/422 (33%), Gaps = 76/422 (18%) Query: 96 QSGVPVIRLAAGEPDF---------DTPKVVAEAGINA-------IREGFTRYTLNAGIT 139 + PV+ E D PK V +A + G L+ T Sbjct: 25 RKDFPVLHQKINEYDLVYFDNAATTQKPKAVIDAIAQFYEKDNSNVHRGVH--ALSVRAT 82 Query: 140 ELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCS----PGDEVII----PAP 191 E+ EA K+K +P + + G +++ ++ + P +E++I Sbjct: 83 EMYEAARAKVKRFINAR-SPRECIFVRGTTEAINLVAQSLVAPRILPDEEILITHMEHHS 141 Query: 192 YWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPK 251 V + + V P + N + ++ E KL E ++++ + SN G++ P Sbjct: 142 NIVPWQMVCKKMGCKLQVAPISL--NGEVILEEFERKLNENTKMVAINYASNSLGTINPV 199 Query: 252 SLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFS--KAFA 309 + ++A VL D + + D+ + FS K + Sbjct: 200 KTMIKMAH----EVGAKVLLD----------GAQATAHLIVDVQDLDCDFYAFSGHKMYG 245 Query: 310 MTGWRLGYLAGPKHIVAACSKLQG---QVSSGASSIAQKAGVA---------------AL 351 TG +G L G + ++ + + QG ++S + + A + Sbjct: 246 PTG--IGVLWGKEELLNSMTPYQGGGEMINSVSFEATEYAAIPHKFEAGTPNIAGAIGLA 303 Query: 352 GLGKAGGETVAEMVKAYRER-RDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEG 410 + + Y + ++ K++ +KG I I F + A Sbjct: 304 AAIDYIWSLDLDAIAEYETQLLNYATKAIEAVKGYNIIGTAANKVPIISF-VHGKIHAHD 362 Query: 411 FGLINDSSSLALYFLDKFQVAMVPGDAFGD-DSCIRISYA-----TSLDVLQAAVEKIRK 464 G I DS +A + +P F D + RIS + +D A++++++ Sbjct: 363 IGTILDSEGIA---IRSGHHCTMPLMDFYDVAATSRISMSFYNTFKEIDYCMEALQRVKE 419 Query: 465 AL 466 Sbjct: 420 VF 421 >1YAA-A nrPDB Length = 412 Score = 57.8 bits (138), Expect = 9e-09, Method: Composition-based stats. Identities = 48/338 (14%), Positives = 88/338 (26%), Gaps = 36/338 (10%) Query: 76 VQSLKPSKTMVITDLAATLVQSGVPVIRLAAG----EPDFDTPKVVAEAGINAIREGFTR 131 ++ L P I + L G + +A I + Sbjct: 8 IELLPPDALFGI--KQRYGQDQRATKVDLGIGAYRDDNGKPWVLPSVKAAEKLIHNDSSY 65 Query: 132 ---YTLNAGITELREAICRKLKEENGLSYAPDQILV-----SNGAKQSLLQAVLAVCSPG 183 Y G+ L + + + D+++ GA + + P Sbjct: 66 NHEYLGITGLPSLTSNAAKIIFGTQSDALQEDRVISVQSLSGTGALH-ISAKFFSKFFPD 124 Query: 184 DEVIIPAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLT---EKSRLLILCS 240 V + P W ++ P + LD + + E S ++ Sbjct: 125 KLVYLSKPTWANHMAIFENQGLKTATYPYWANETKSLDLNGFLNAIQKAPEGSIFVLHSC 184 Query: 241 PSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPD-----MY 295 NPTG +I IA + L D Y+ ++A Sbjct: 185 AHNPTGLDPTSEQWVQIVDAIASKNHI-ALFDTAYQGFATGDLDKDAYAVRLGVEKLSTV 243 Query: 296 ERTLTVNGFSKAFAMTGWRLGYL-----------AGPKHIVAACSKLQGQVSSGASSIAQ 344 F+K M G R+G + + +K+ S + Sbjct: 244 SPVFVCQSFAKNAGMYGERVGCFHLALTKQAQNKTIKPAVTSQLAKIIRSEVSNPPAYGA 303 Query: 345 KAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLGDI 382 K L + + +MV R + +L D Sbjct: 304 KIVAKLLETPELTEQWHKDMVT-MSSRITKMRHALRDH 340 >5TSU-A nrPDB Length = 422 Score = 57.8 bits (138), Expect = 1e-08, Method: Composition-based stats. Identities = 22/138 (15%), Positives = 52/138 (37%), Gaps = 23/138 (16%) Query: 176 VLAVCSPGDEVIIPAPYWVS----YTEQARLADATPVVIPTKISNNFLLDPKDLESKLTE 231 + + GD++I + + + A + K LE+ +T Sbjct: 114 ITHLLKAGDQIICMDDVYGGTNLYFRQVASEFGLKISFVDCS-------KIKLLEAAITP 166 Query: 232 KSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASL 291 +++L+ + +P+NPT V +E A I+ KH ++++ D + + + Sbjct: 167 ETKLVWIETPTNPTQKVID---IEGCAHIVHKHGDIILVVDNTFM---------SPYFQR 214 Query: 292 PDMYERTLTVNGFSKAFA 309 P +++ +K Sbjct: 215 PLALGADISMYSATKYMN 232 >3BB8-A nrPDB Length = 437 Score = 57.0 bits (136), Expect = 2e-08, Method: Composition-based stats. Identities = 47/293 (16%), Positives = 98/293 (33%), Gaps = 58/293 (19%) Query: 141 LREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSP---------GDEVIIPAP 191 +A +KL E G+ Y +L + + L A+ A+ SP GDEVI A Sbjct: 63 FNDAFEKKLGEYLGVPY----VLTTTSGSSANLLALTALTSPKLGVRALKPGDEVITVAA 118 Query: 192 YWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPK 251 + + PV + I + ++ +E+ +++K++ +++ + G+++ Sbjct: 119 GFPTTVNPTIQNGLIPVFVDVDIPT-YNVNASLIEAAVSDKTKAIMIA---HTLGNLFD- 173 Query: 252 SLLEEIARIIAKHPRLLVLSDEI------YEH-----------IIYAPATHTSFASLPDM 294 L E+ R+ K+ L ++ D Y+ + + PA H + + Sbjct: 174 --LAEVRRVADKY-NLWLIEDCCDALGSTYDGKMAGTFGDIGTVSFYPAKHITMGEGGAV 230 Query: 295 YERTLTVNGFSKAFAMTG--------------WRLGYLAGPKHIVAACSKLQGQVSSGAS 340 + ++ + ++F G R G G + Sbjct: 231 FTQSAELKSIIESFRDWGRDCYCAPGCDNTCKKRFGQQLGSLPFGYDHKYTYSHLGYNL- 289 Query: 341 SIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLGDIKGVKISEPQGA 393 I L + E V + + +L +L I P+ Sbjct: 290 KITDMQAACGLAQLERIEEFVEKR----KANFKYLKDALQSCADF-IELPEAT 337 >3QI6-A nrPDB Length = 392 Score = 57.0 bits (136), Expect = 2e-08, Method: Composition-based stats. Identities = 31/216 (14%), Positives = 74/216 (34%), Gaps = 25/216 (11%) Query: 175 AVLAVCSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSR 234 A+ A+ PGD V+IP +Y RL D + + L D + + + +R Sbjct: 97 ALRAMLRPGDHVVIPD---DAYGGTFRLIDKVFTGWNVEYTPVALADLDAVRAAIRPTTR 153 Query: 235 LLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDM 294 L+ + +P+NP S+ + + ++ ++LV + P Sbjct: 154 LIWVETPTNPLLSIADIAGIAQLG--ADSSAKVLV-----------DNTFASPALQQPLS 200 Query: 295 YERTLTVNGFSKAFAMTGWRLG--YLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALG 352 + ++ +K +G + + + + + LQ + + Sbjct: 201 LGADVVLHSTTKYIGGHSDVVGGALVTNDEELDQSFAFLQNGAGAVPGPFDAYLTM---- 256 Query: 353 LGKAGGETVAEMVKAYRERRDFLVKSLGDIKGVKIS 388 G +T+ ++ + E + + L + + Sbjct: 257 ---RGLKTLVLRMQRHSENAAAVAEFLAEHPAISTV 289 >2CST-A nrPDB Length = 411 Score = 56.7 bits (135), Expect = 2e-08, Method: Composition-based stats. Identities = 58/387 (14%), Positives = 118/387 (30%), Gaps = 45/387 (11%) Query: 76 VQSLKPSKTMVITDLAATLVQSG-VPVIRLAAG--EPDFDTPKVVAEAGINAIREGFTR- 131 ++ + + + L A + G + L G D P V+ + + + Sbjct: 5 FAAVPRAPPVAVFKLTADFREDGDSRKVNLGVGAYRTDEGQPWVLP--VVRKVEQLIAGD 62 Query: 132 ------YTLNAGITELREAICRKLKEENGLSYAPDQI--LVSNGAKQSLLQAVLAVCSP- 182 Y G+ E R R ++ + A ++ + G +L + Sbjct: 63 GSLNHEYLPILGLPEFRANASRIALGDDSPAIAQKRVGSVQGLGGTGAL-RIGAEFLRRW 121 Query: 183 --GDE-----VIIPAPYWVSYTEQARLADATPVVI-----PTKISNNFLLDPKDLESKLT 230 G+ V + +P W ++ A + K + D+E Sbjct: 122 YNGNNNTATPVYVSSPTWENHNSVFMDAGFKDIRTYRYWDAAKRGLDLQGLLDDMEKA-P 180 Query: 231 EKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFAS 290 E S ++ NPTG+ ++IA + K L D Y+ ++A Sbjct: 181 EFSIFILHACAHNPTGTDPTPDEWKQIA-AVMKRRCLFPFFDSAYQGFASGSLDKDAWAV 239 Query: 291 --LPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQV-----SSGASSIA 343 FSK F + R+G L+ ++ Q+ ++ ++ + Sbjct: 240 RYFVSEGFELFCAQSFSKNFGLYNERVGNLSVVGKDEDNVQRVLSQMEKIVRTTWSNPPS 299 Query: 344 QKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAY 403 Q A + A L + AE + D ++ L + E G + + Sbjct: 300 QGARIVATTL--TSPQLFAEWKDNVKTMADRVL--LMRSELRSRLESLGTPGTWNHITDQ 355 Query: 404 YGSEAEGFGLINDSSSLALYFLDKFQV 430 G F + Y + + + Sbjct: 356 IGM----FSFTGLNPKQVEYMIKEKHI 378 >5TON-A nrPDB Length = 414 Score = 55.9 bits (133), Expect = 3e-08, Method: Composition-based stats. Identities = 58/384 (15%), Positives = 115/384 (29%), Gaps = 46/384 (11%) Query: 83 KTMVITDLAATLVQSGVPVIRLAAGEPDFDTPKVVAEAGINAIREGF-------TRYTLN 135 +V +A + L G D + + + + Y Sbjct: 16 PVLVFKLIADFREDPDPRKVNLGVGAYRTDDCQPWVLPVVRKVEQRIANNSSLNHEYLPI 75 Query: 136 AGITELREAICRKLKEENGLSYAPDQI--LVSNGAKQSLLQAVLAVC-------SPGDEV 186 G+ E R R ++ + ++ + S G +L + + V Sbjct: 76 LGLAEFRTCASRLALGDDSPALQEKRVGGVQSLGGTGALRIGAEFLARWYNGTNNKDTPV 135 Query: 187 IIPAPYWVSYTEQARLADATPVVIPTKISNNF-----LLDPKDLESKLTEKSRLLILCS- 240 + +P W + A + + LD + S L I Sbjct: 136 YVSSPTWENLNGVFTTAGFK----DIRSYRYWDTEKRGLDLQGFLSDLENAPEFSIFVLH 191 Query: 241 --PSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFAS--LPDMYE 296 NPTG+ ++IA + K L D Y+ ++A Sbjct: 192 ACAHNPTGTDPTPEQWKQIAS-VMKRRFLFPFFDSAYQGFASGNLEKDAWAIRYFVSEGF 250 Query: 297 RTLTVNGFSKAFAMTGWRLGYLAG----PKHIVAACSKLQGQVSSG-ASSIAQKAGVAAL 351 FSK F + R+G L P I+ S++Q V ++ AQ A + A Sbjct: 251 ELFCAQSFSKNFGLYNERVGNLTVVAKEPDSILRVLSQMQKIVRVTWSNPPAQGARIVAR 310 Query: 352 GLGKAGGETVAEMVKAYRERRDFLVKSLGDIKG-VKISEPQGAFYLFIDFSAYYGSEAEG 410 L + E E + D ++ +++ ++ + G + + G Sbjct: 311 TL--SDPELFHEWTGNVKTMADRILSMRSELRARLEALKTPGT---WNHITDQIGM---- 361 Query: 411 FGLINDSSSLALYFLDKFQVAMVP 434 F + Y +++ + ++P Sbjct: 362 FSFTGLNPKQVEYLINQKHIYLLP 385 >3K7Y-A nrPDB Length = 405 Score = 55.9 bits (133), Expect = 4e-08, Method: Composition-based stats. Identities = 43/259 (16%), Positives = 86/259 (33%), Gaps = 22/259 (8%) Query: 76 VQSLKPSKTMVITDLAATLVQSG-VPVIRLAAG-----EPDFDTPKVVAEAGINAIREGF 129 + SL+ + I A + I L+ G + D V A Sbjct: 5 LSSLENIEVDNILKTAREFKEDTCEEKINLSIGVCCNDDGDLHIFDSVLNADKLVTENYK 64 Query: 130 TR-YTLNAGITELREAICRKLKEENGLSYAPDQILVSN---GAKQSLLQAVLAVCSPGDE 185 + Y L G + + + L N Y D+ + + G ++ + + E Sbjct: 65 EKPYLLGNGTEDF-STLTQNLIFGNNSKYIEDKKICTIQCIGGTGAIFVLLEFLKMLNVE 123 Query: 186 VI-IPAPYWVSYTEQARLADATPVVIPTKISN----NFLLDPKDLESKLTEKSRLLILCS 240 + + P ++++ I N N+ L DL + + S +++ S Sbjct: 124 TLYVTNPPYINHVNMIESRGFNLKYINFFDYNLIDINYDLFLNDLRN-IPNGSSVILQIS 182 Query: 241 PSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTL- 299 NP + +EI I+ H + +++ D Y+ + + E+ + Sbjct: 183 CYNPCSVNIEEKYFDEIIEIVL-HKKHVIIFDIAYQGFGHTNLEEDVLL-IRKFEEKNIA 240 Query: 300 --TVNGFSKAFAMTGWRLG 316 FSK ++ G R G Sbjct: 241 FSVCQSFSKNMSLYGERAG 259 >1CS1-A nrPDB Length = 386 Score = 55.5 bits (132), Expect = 6e-08, Method: Composition-based stats. Identities = 39/230 (16%), Positives = 78/230 (33%), Gaps = 33/230 (14%) Query: 163 LVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWV-SYTEQARLADATPVVIPTKISNNFLLD 221 +++N ++ PGD ++ P + SY LA + D Sbjct: 71 VLTNTGMSAIHLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQG----D 126 Query: 222 PKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYA 281 + L + L EK +L+++ SPSNP V + +I + + + V+ Sbjct: 127 EQALRAALAEKPKLVLVESPSNPLLRVVD---IAKICHLAREVGAVSVV----------D 173 Query: 282 PATHTSFASLPDMYERTLTVNGFSKAFA-----MTGWRLGYLAGPKHIVAACSKLQGQVS 336 + P L ++ +K + G ++A + +++ Sbjct: 174 NTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGV----------VIAKDPDVVTELA 223 Query: 337 SGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLGDIKGVK 386 A++I G L G T+ ++ + +VK L VK Sbjct: 224 WWANNIGVTGGAFDSYLLLRGLRTLVPRMELAQRNAQAIVKYLQTQPLVK 273 >6MRE-A nrPDB Length = 420 Score = 55.1 bits (131), Expect = 6e-08, Method: Composition-based stats. Identities = 57/400 (14%), Positives = 116/400 (29%), Gaps = 70/400 (17%) Query: 114 PKVVAEAGINAIREGFTRYTLNAGITELREAICRKLKEENGLSY------APDQILVSNG 167 P V +A R G+ ++ GI L K++ + + ++++ G Sbjct: 50 PSQVIDAEAEFYRHGYA--AVHRGIHTLSAQATEKMENVRKRASLFINARSAEELVFVAG 107 Query: 168 AKQSLLQAVLAVCS----PGDEVII----PAPYWVSYTEQARLADATPVVIPTKISNNFL 219 + + + + GD +II V + A VIP Sbjct: 108 TTEGINLVANSWGNSNVRAGDNIIISQMEHHANIVPWQMLCARVGAELRVIPLNPDGTLQ 167 Query: 220 LDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHII 279 L + L + EK+RLL + SN G ++ L E+ + +H VL D + Sbjct: 168 L--ETLPTLFDEKTRLLAITHVSNVLG---TENPLAEMITLAHQH-GAKVLVDGAQAVMH 221 Query: 280 YAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRL-----------------GYLAGPK 322 + + V K + TG + G + Sbjct: 222 HPVD--------VQALDCDFYVFSGHKLYGPTGIGILYVKEALLQEMPPWEGGGSMIATV 273 Query: 323 HIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERR-DFLVKSLGD 381 + + + A + + + + Y + + + L Sbjct: 274 SLSEGTTWTKAPWRFEAGTPNTGGIIGLGAALEYVSALGLNNIAEYEQNLMHYALSQLES 333 Query: 382 IKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVAMVPGDA---- 437 + + + PQ F L + FLD + +A+ G Sbjct: 334 VPDLTLYGPQ------------NRLGVIAFNLGKHHAYDVGSFLDNYGIAVRTGHHCAMP 381 Query: 438 ----FGDDSCIRISYATSLDVLQAAVEKIRKALEPLRATV 473 + + R S A + V+++ L+ + + Sbjct: 382 LMAYYNVPAMCRASLA--MYNTHEEVDRLVTGLQRIHRLL 419 >4QGR-A nrPDB Length = 382 Score = 54.7 bits (130), Expect = 8e-08, Method: Composition-based stats. Identities = 30/164 (18%), Positives = 60/164 (36%), Gaps = 24/164 (14%) Query: 120 AGINAIREGFTRYTLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAV 179 A + EG RY L + E + + L E+ I +NG + + Sbjct: 28 AISKVVAEG--RYILGPEVAEFEKKLGEYLGVEH-------VIACANGTDALQMPLMTRG 78 Query: 180 CSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTE-------K 232 PG V +P+ + + E L A PV + +++ ++ + LE+ + + Sbjct: 79 IGPGHAVFVPSFTFAATAEVVALVGAEPVFVDVDP-DSYNMNVEQLEAAIAATIKEGRLE 137 Query: 233 SRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYE 276 + +I P + G + + I A+ L ++ D Sbjct: 138 PKAII---PVDLFGLAASYNRITAI----AEREGLFIIEDAAQS 174 >1IBJ-A nrPDB Length = 464 Score = 54.0 bits (128), Expect = 1e-07, Method: Composition-based stats. Identities = 62/348 (17%), Positives = 117/348 (33%), Gaps = 63/348 (18%) Query: 53 CAMAKPNDAETLSSSVDMSLSPRVQSLKPSKTMVITDLAATLVQSGVPVIRLAAGEPDFD 112 C M K D +T S+V+ + TM I + A+ ++ L FD Sbjct: 55 CVMEKSVDGQT-HSTVN-------NTTDSLNTMNIKEEAS----VSTLLVNLDNKFDPFD 102 Query: 113 ---TPKVVAEAGIN--AIREGFTRYTLNAGITELREAICRKLKEENGLSYAPDQILVSNG 167 TP AI G YT + G R+A+ L + L A ++G Sbjct: 103 AMSTPLYQTATFKQPSAIENGPYDYTRS-GNPT-RDALESLLAK---LDKADRAFCFTSG 157 Query: 168 AKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLA----DATPVVIPTKISNNFLLDPK 223 + L AV + G+E++ + + T Sbjct: 158 M--AALSAVTHLIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTT-------KLD 208 Query: 224 DLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPA 283 ++ + + +++L+ L SP+NP + + E+A LVL D + Sbjct: 209 EVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHA----QGALVLVD---------NS 255 Query: 284 THTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIA 343 + S P + ++ +K ++AG ++A ++G+ + Sbjct: 256 IMSPVLSRPLELGADIVMHSATK----------FIAGHSDVMAGVLAVKGEKLAKEVYFL 305 Query: 344 QKAGVAALGLGKA-----GGETVAEMVKAYRERRDFLVKSLGDIKGVK 386 Q + + L G +T+A ++ +E + L VK Sbjct: 306 QNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENARKIAMYLSSHPRVK 353 >6CJB-A nrPDB Length = 391 Score = 53.2 bits (126), Expect = 3e-07, Method: Composition-based stats. Identities = 39/204 (19%), Positives = 72/204 (35%), Gaps = 34/204 (16%) Query: 113 TPKVVAEAGINAIREGFTRYTLNAGITELREA----ICRKLKEENGLSYAPDQILVSNGA 168 TP Y + R+A I + G ++A Sbjct: 34 TPIYATSTYKQIAPGEHLGYEYSRTQNPTRKAYEDCIASLESGQKGFAFAS--------G 85 Query: 169 KQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNNFLLD---PKDL 225 ++ + + GD V+ Y RL D V T + +D P+++ Sbjct: 86 MAAINTVID-LLGSGDHVVAMD---DLYGGTFRLFD--KVKTRTSNLSFSFIDMSVPENI 139 Query: 226 ESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATH 285 E+ +T K++LL L +PSNP + + L +IA I K+ L+ ++D + Sbjct: 140 EAAITPKTKLLWLETPSNP---MLKLANLRKIAAIAKKY-NLITVADNTFA--------- 186 Query: 286 TSFASLPDMYERTLTVNGFSKAFA 309 T + P + ++ +K Sbjct: 187 TPWIQRPLELGFDIVLHSATKYLN 210 >3LVM-A nrPDB Length = 423 Score = 53.2 bits (126), Expect = 3e-07, Method: Composition-based stats. Identities = 43/241 (17%), Positives = 85/241 (35%), Gaps = 25/241 (10%) Query: 155 LSYAPDQILVSNGAKQSLLQAVLAVCS----PGDEVIIPAPYWVSYTEQARLADATPVVI 210 + P +I+ ++GA +S A+ + G +I + + R + + Sbjct: 81 VGADPREIVFTSGATESDNLAIKGAANFYQKKGKHIITSKTEHKAVLDTCRQLEREGFEV 140 Query: 211 -PTKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLV 269 N ++D K+LE+ + + + L+ + +N G V + + E+ R Sbjct: 141 TYLAPQRNGIIDLKELEAAMRDDTILVSIMHVNNEIGVVQDIAAIGEMCRA--------- 191 Query: 270 LSDEIYEHIIYAPATHTSFASLP-DMYERTLTVNGFS--KAFAMTGWRLGYLAGPKHIVA 326 IIY S LP D+ + + + FS K + G Y+ + Sbjct: 192 ------RGIIYHVDATQSVGKLPIDLSQLKVDLMSFSGHKIYGPKGIGALYVRRKPRVRI 245 Query: 327 ACSKLQGQVSSGA--SSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLGDIKG 384 G G ++ V + E +A ++ R R+ L + DI+ Sbjct: 246 EAQMHGGGHERGMRSGTLPVHQIVGMGEAYRIAKEEMATEMERLRGLRNRLWNGIKDIEE 305 Query: 385 V 385 V Sbjct: 306 V 306 >3WGB-A nrPDB Length = 341 Score = 53.2 bits (126), Expect = 3e-07, Method: Composition-based stats. Identities = 62/368 (16%), Positives = 123/368 (33%), Gaps = 53/368 (14%) Query: 112 DTPKVVAEAGINAIREGFTR---YTLNAGITELREAICRKLKEENGLSYAPDQILVSNGA 168 DT +A + Y + G+ L L +E L V +G Sbjct: 12 DTVTQPTDAMRQCMLHAEVGDDVYGEDPGVNALEAYGADLLGKEAAL-------FVPSGT 64 Query: 169 KQSLLQAVLAVCSPGDEVII--PAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLE 226 +L AV++ C G+ ++ A + + + + + + P + + L D+ Sbjct: 65 MSNL-LAVMSHCQRGEGAVLGSAAHIYRYEAQGSAVLGSVALQ-PVPMQADGSLALADVR 122 Query: 227 SKLTE------KSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIY 280 + + +RL+ L + N G V P L E+ ++ +H L + D Sbjct: 123 AAIAPDDVHFTPTRLVCLENTHN--GKVLPLPYLREMRELVDEH-GLQLHLDGARLFNAV 179 Query: 281 APATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGAS 340 + HT L ++ SK L L G +A +L+ V G Sbjct: 180 VASGHT-VRELVAPFDSVSIC--LSKGLGAPVGSL--LVGSHAFIARARRLRKMVGGGM- 233 Query: 341 SIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLGDIKGVKISEPQGAFYLFIDF 400 ++AG+ A A + V + +R R L + L + G++ +D Sbjct: 234 ---RQAGILAQAGLFALQQHVVRLADDHRRARQ-LAEGLAALPGIR-----------LDL 278 Query: 401 SAYYGSEAEGFGLINDSSSLALYFLDKFQVAMVPGDAFGDDSCIRISYATS--LDVLQAA 458 + + +S+ L + + G F +R+ D ++ Sbjct: 279 AQVQTNMVFLQLTSGESAPLLAFMKAR-------GILFSGYGELRLVTHLQIHDDDIEEV 331 Query: 459 VEKIRKAL 466 ++ + L Sbjct: 332 IDAFTEYL 339 >4L0O-H nrPDB Length = 388 Score = 52.0 bits (123), Expect = 6e-07, Method: Composition-based stats. Identities = 58/333 (17%), Positives = 112/333 (33%), Gaps = 76/333 (22%) Query: 174 QAVLAVCSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKS 233 AV ++ GD V++ Y RL + V + D ++ + + Sbjct: 79 HAVFSLLQSGDHVLLGD---DVYGGTFRLFNQVLVKNGLSCTIIDTSDISQIKKAIKPNT 135 Query: 234 RLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPD 293 + L L +PSNP + + +AK LL + D + T + P Sbjct: 136 KALYLETPSNPLLKITDLAQ----CASVAKDHGLLTIVDNTFA---------TPYYQNPL 182 Query: 294 MYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAAC-----SKLQGQVSSGASSIAQKAGV 348 + + + +K YL G +VA L +++ ++I G Sbjct: 183 LLGADIVAHSGTK----------YLGGHSDVVAGLVTTNNEALAQEIAFFQNAIGGVLGP 232 Query: 349 AALGLGKAGGETVAEMVKAYRERRDFLVKSLGDIKGVK-------ISEPQGAFYLFIDFS 401 L + G +T+ ++A+++ + + L V+ + P Y Sbjct: 233 QDSWLLQRGIKTLGLRMEAHQKNALCVAEFLEKHPKVERVYYPGLPTHPN---YELAKKQ 289 Query: 402 AYYGSEAEGFGLINDSSSLALYFLDKFQVAMVPGDAFGD--------------------- 440 S F L NDS ++A F++ ++ ++ G++ G Sbjct: 290 MRGFSGMLSFTLKNDSEAVA--FVESLKLFIL-GESLGGVESLVGIPAFMTHACIPKTQR 346 Query: 441 ------DSCIRISYATS-----LDVLQAAVEKI 462 D +R+S L+ L+ A KI Sbjct: 347 EAAGIRDGLVRLSVGIEHEQDLLEDLEQAFAKI 379 >5X5H-A nrPDB Length = 392 Score = 51.7 bits (122), Expect = 7e-07, Method: Composition-based stats. Identities = 39/282 (13%), Positives = 97/282 (34%), Gaps = 36/282 (12%) Query: 118 AEAGINAIREGFTRYTL--NAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQA 175 A+ N +R+G+ YT N I L + + + G +++ + Sbjct: 39 AQNAPNELRKGYE-YTRVGNPTIVALEQTVAALEGAKYGRAFSS--------GMAATDIL 89 Query: 176 VLAVCSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRL 235 + PGD +++ +Y RL D + + +++++ + + ++L Sbjct: 90 FRIILKPGDHIVLGN---DAYGGTYRLIDTVFTAWGVEYTVVDTSVVEEVKAAIKDNTKL 146 Query: 236 LILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMY 295 + + +P+NP + +E +A++ LV+ + + P Sbjct: 147 IWVETPTNP---ALGITDIEAVAKLTEGTNAKLVV----------DNTFASPYLQQPLKL 193 Query: 296 ERTLTVNGFSKAFAMTGWRLG--YLAGPKHIVAACSKLQGQVSSGASSIAQKAGV----- 348 ++ +K +G + + + +QG + S Sbjct: 194 GAHAVLHSTTKYIGGHSDVVGGLVVTNDQEMDEELLFMQGGIGPIPSVFDAYLTARGLKT 253 Query: 349 AALGLGKAGG--ETVAEMVKAYRERRDFLVKSLGDIKGVKIS 388 A+ + + E +AE + + E L L + G +++ Sbjct: 254 LAVRMDRHCDNAEKIAEFLDSRPEVSTVLYPGLKNHPGHEVA 295 >5IJG-A nrPDB Length = 427 Score = 50.5 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 33/229 (14%), Positives = 78/229 (34%), Gaps = 21/229 (9%) Query: 163 LVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQAR---LADATPVVIPTKISNNFL 219 L S+G ++ + A PGD ++ P + V + Sbjct: 103 LFSSGMS-AIATTLFAFVRPGDVILHSQPLYGGTETLLAKTFFNFGVEAVAFADGVHEAT 161 Query: 220 LDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIAR-IIAKHPRLLVLSDEIYEHI 278 ++ E+ + ++++ +P+NPT S+ + + +A I A+ V+ ++ Sbjct: 162 IEKAAEEALAKGRVSVILIETPANPTNSIVDVAAVRRVAEKIEARQGSRPVI---ACDNT 218 Query: 279 IYAPATHTSFASLPDMYERTLTVNGFSKAFAM-TGWRLGYLAGPKHIVAACSKLQGQVSS 337 + P + L+V +K + G + G K +V L+G + + Sbjct: 219 LLGPVFQKPL-----DHGADLSVYSLTKYVGGHSDLIAGAVLGAKSVVRQVKALRGAIGT 273 Query: 338 GASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLGDIKGVK 386 + + ET+ ++ + + L + V+ Sbjct: 274 QLDP-------HSCWMLGRSLETLGLRMERADSNARAIAEFLRNHPKVE 315 >1N8P-A nrPDB Length = 393 Score = 49.7 bits (117), Expect = 3e-06, Method: Composition-based stats. Identities = 39/207 (18%), Positives = 79/207 (38%), Gaps = 26/207 (12%) Query: 139 TELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGD-EVIIPAPYWVSYT 197 L A+ + GL++ S+G+ + +L G V I Y ++ Sbjct: 58 ENLERAVAALENAQYGLAF-------SSGS--ATTATILQSLPQGSHAVSIGDVYGGTHR 108 Query: 198 EQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEI 257 ++A+A V T +N+ DL + E ++L+ + +P+NPT V + ++ Sbjct: 109 YFTKVANAHGVE--TSFTNDL---LNDLPQLIKENTKLVWIETPTNPTLKVTDIQKVADL 163 Query: 258 ARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAM-TGWRLG 316 + A ++++ D + + S P + + V+ +K + LG Sbjct: 164 IKKHAAGQDVILVVD---------NTFLSPYISNPLNFGADIVVHSATKYINGHSDVVLG 214 Query: 317 YLA-GPKHIVAACSKLQGQVSSGASSI 342 LA K + LQ + + S Sbjct: 215 VLATNNKPLYERLQFLQNAIGAIPSPF 241 >4OC9-A nrPDB Length = 424 Score = 49.7 bits (117), Expect = 3e-06, Method: Composition-based stats. Identities = 34/188 (18%), Positives = 68/188 (36%), Gaps = 20/188 (10%) Query: 143 EAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARL 202 + + ++L G ++ I V++G + A++ + S GD V Y L Sbjct: 63 DVLGQRLANVEGGAFG---IPVASG-MAACFYALINLASSGDNVAYSN---KIYGGTQTL 115 Query: 203 ADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIA 262 T + + D LE + + ++ + S SNP ++ +E+I +I Sbjct: 116 ISHTLKNFGIEAREFDIDDLDSLEKVIDQNTKAIFFESLSNPQIAIAD---IEKINQIAK 172 Query: 263 KHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPK 322 KH + + + + + P H + V+ SK + G LG + Sbjct: 173 KHKIVSICDNTVATPFLLQPFKH----------GVDVIVHSLSKYVSGQGTALGGALIER 222 Query: 323 HIVAACSK 330 + K Sbjct: 223 KDLNDLLK 230 >4BMK-A nrPDB Length = 442 Score = 49.7 bits (117), Expect = 3e-06, Method: Composition-based stats. Identities = 65/353 (18%), Positives = 104/353 (29%), Gaps = 52/353 (14%) Query: 56 AKPNDA------ETLSSSVDMSLSPRVQSLKPSKT------MVITDLAATLVQSGVPVIR 103 A P DA L S D ++ R + L T M V G I Sbjct: 31 ALPADAPDIAPERDLLSKFDGLIAERQKLLDSGVTDPFAIVMEQVKSPTEAVIRGKDTIL 90 Query: 104 LAAGE---PDFDTPKVVAEAGINAIRE---GFTRYTLNAGI----TELREAICRKLKEEN 153 L FD V AG A+ + G + G E+ +A+ Sbjct: 91 LGTYNYMGMTFDPD--VIAAGKEALEKFGSGTNGSRMLNGTFHDHMEVEQALRDFYGTTG 148 Query: 154 GLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADATPVVIPTK 213 I+ S G + L + + G+ VI+ A S + + +A V Sbjct: 149 A-------IVFSTG-YMANLGIISTLAGKGEYVILDADSHASIYDGCQQGNAEIVRFRHN 200 Query: 214 ISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPK----SLLEEIARIIAKHPRLLV 269 + K L E ++L++L VY + L+E+ + KH +V Sbjct: 201 SVEDL---DKRLGRLPKEPAKLVVLE-------GVYSMLGDIAPLKEMVAVAKKH-GAMV 249 Query: 270 LSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACS 329 L DE + + P + + + V FS + G G++ A Sbjct: 250 LVDEAHSMGFFGPNGRGVYEAQGLEGQIDFVVGTFSASVGTVG---GFVVSNHPKFEAVR 306 Query: 330 KLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLGDI 382 AS A + K E + L L + Sbjct: 307 LACRPYIFTASLPPSVVATATTSIRKLMTAH--EKRERLWSNARALHGGLKAM 357 >5W1B-A nrPDB Length = 467 Score = 49.3 bits (116), Expect = 4e-06, Method: Composition-based stats. Identities = 52/391 (13%), Positives = 118/391 (30%), Gaps = 57/391 (14%) Query: 128 GFTRYTLNAGITELREAICRKLKEENGLSY----APDQILVSNGAKQSLLQAVLAVCSPG 183 G Y + +L++ + + + IL LL+ Sbjct: 68 GDEAYAGSRNYYDLKDKAKELFNYDYIIPAHQGRGAENILF-----PVLLKYKQKEGKAK 122 Query: 184 DEVIIPAPYWVSYTEQARLADATPVVI------PTKISNNFL--LDPKDLESKLT----E 231 + V I ++ + L + I ++ +++ D K L+ + + Sbjct: 123 NPVFISNFHFDTTAAHVELNGCKAINIVTEKAFDSETYDDWKGDFDIKKLKENIAQHGAD 182 Query: 232 KSRLLILCSPSNPTG-SVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFAS 290 ++ N G S L+E+ I +H +V+ + Y Sbjct: 183 NIVAIVSTVTCNSAGGQPVSMSNLKEVYEIAKQHGIFVVMDSARFCENAYFIKARDPKYK 242 Query: 291 LPDMYERTLTVNGFSKAFAMTGWR-----LGYLAGPKHIVAACSKLQGQV-----SSGAS 340 + E + ++ A M+ + +G L + + + + Sbjct: 243 NATIKEVIFDMYKYADALTMSAKKDPLLNIGGLVAIRDNEEIFTLARQRCVPMEGFVTYG 302 Query: 341 SIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLGDIKGVKISEPQGAFYLFIDF 400 +A + A + + G E E + + +L L + G+ I P G +F+D Sbjct: 303 GLAGRDMAAMVQGLEEGTE--EEYLHYRIGQVKYLGDRLREA-GIPIQYPTGGHAVFVDC 359 Query: 401 SAYYGSEAEGFGLINDSSSLALYFLDKFQVAMVPGDAF--GDD-----------SCIRIS 447 G + ++ + V V +F G D +R++ Sbjct: 360 KKLVPQIP---GDQFPAQAVINALYLESGVRAVEIGSFLLGRDPATGEQKHADMEFMRLT 416 Query: 448 YATS------LDVLQAAVEKIRKALEPLRAT 472 A +D + A+ +++ L+ Sbjct: 417 IARRVYTNDHMDYIADALIGLKEKFATLKGL 447 >4IYO-A nrPDB Length = 397 Score = 49.3 bits (116), Expect = 4e-06, Method: Composition-based stats. Identities = 36/216 (16%), Positives = 73/216 (33%), Gaps = 29/216 (13%) Query: 176 VLAVCSPGDEVIIPAPYWVSYTEQA-----RLADATPVVIPTKISNNFLLDPKDLESKLT 230 V+ + G V+ + R A + DP ++ + Sbjct: 95 VMELLDAGSHVVAMDDLYGGTFRLFERVRRRTAGLDFSFVDLT-------DPAAFKAAIR 147 Query: 231 EKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFAS 290 ++++ + +P+NP + + IA I KH L V+ + Sbjct: 148 ADTKMVWIETPTNP---MLKLVDIAAIAVIARKHGLLTVV----------DNTFASPMLQ 194 Query: 291 LPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAA 350 P L V+ +K +G +A +V ++L Q++ +SI G Sbjct: 195 RPLSLGADLVVHSATKYLNGHSDMVGGIA----VVGDNAELAEQMAFLQNSIGGVQGPFD 250 Query: 351 LGLGKAGGETVAEMVKAYRERRDFLVKSLGDIKGVK 386 L G +T+ ++A+ E L + L ++ Sbjct: 251 SFLALRGLKTLPLRMRAHCENALALAQWLETHPAIE 286 >5WGB-A nrPDB Length = 426 Score = 48.6 bits (114), Expect = 6e-06, Method: Composition-based stats. Identities = 53/327 (16%), Positives = 109/327 (33%), Gaps = 44/327 (13%) Query: 112 DTPKVVAEAGINAI-------REGFTRYT--LNAGITELREAICRKLKEENGLSYAPDQI 162 V +A + + Y A + R+ + + P +I Sbjct: 37 PLDPRVLDAMLPYLINYYGNPHSRTHAYGWESEAAMERARQQVASL------IGADPREI 90 Query: 163 LVSNGAKQSLLQAVLAVC----SPGDEVIIPAPYWVSYTEQARLADATPVVI-PTKISNN 217 + ++GA +S A+ V S +I + R +A + + + Sbjct: 91 IFTSGATESNNIAIKGVARFYRSRKKHLITTQTEHKCVLDSCRSLEAEGFQVTYLPVQKS 150 Query: 218 FLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEH 277 ++D K+LE+ + + L+ + + +N G K + EI RI + +Y H Sbjct: 151 GIIDLKELEAAIQPDTSLVSVMTVNNEIGV---KQPIAEIGRICSSRK--------VYFH 199 Query: 278 IIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQ----- 332 A A + DM ++++G K + G +G + + LQ Sbjct: 200 TDAAQAVGKIPLDVNDMKIDLMSISG-HKIYGPKG--VGAIYIRRRPRVRVEALQSGGGQ 256 Query: 333 --GQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLGDIKGVKIS-E 389 G S + AA + + E + + ER + + + V ++ + Sbjct: 257 ERGMRSGTVPTPLVVGLGAACEVAQQEMEYDHKRISKLSER--LIQNIMKSLPDVVMNGD 314 Query: 390 PQGAFYLFIDFSAYYGSEAEGFGLIND 416 P+ + I+ S Y + D Sbjct: 315 PKHHYPGCINLSFAYVEGESLLMALKD 341 >4U1T-A nrPDB Length = 389 Score = 47.0 bits (110), Expect = 2e-05, Method: Composition-based stats. Identities = 51/282 (18%), Positives = 95/282 (33%), Gaps = 33/282 (11%) Query: 105 AAGEPDFDTPKVVAEAGINAIREGFTRYTLNAGITELREAICRKLKEENGLSYAPDQILV 164 +AG D P V+ ++ RY G RE + L GL AP + Sbjct: 18 SAGTGDVVPPIHVSTTYERRAQDEP-RYFYGRGENPTREELEECLA---GLERAPFATVF 73 Query: 165 SNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKD 224 S+G Q+ +L++ PG V+ + LA V + L P+ Sbjct: 74 SSG--QAAAATLLSLVRPGQCVVSTDDVYAGTDGLFDLAARQGVRVRYAD----LTTPEG 127 Query: 225 LESKLTEKS-RLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPA 283 + + L E L+ + +P+NP +V + E++R + +V+ Sbjct: 128 IAAALAEPDLALVWIETPTNPLLTVVD---VAEVSRRAHERGARVVV----------DNT 174 Query: 284 THTSFASLPDMYERTLTVNGFSKAFAMTGWRLG--YLAGPKHIVAACSKLQGQVSSGASS 341 + P +++ +K+ A LG + + AA + + + Sbjct: 175 FASPVLQQPLALGADVSLYSTTKSIAGHADVLGGALVYRDADLHAAVRAYRTTAGNVPGA 234 Query: 342 IAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLGDIK 383 + L + G T++ V LV+ L Sbjct: 235 LDCF-------LVRRGLHTLSLRVHRQVATARVLVERLRASP 269 >3N0L-A nrPDB Length = 417 Score = 47.0 bits (110), Expect = 2e-05, Method: Composition-based stats. Identities = 46/328 (14%), Positives = 102/328 (31%), Gaps = 30/328 (9%) Query: 83 KTMVITDLAATLVQSGVPVIRLAAGEPDFDTPKVVA---EAGINAIREGF---TRYTLNA 136 + +T+ G+ +I +F P+V+ N EG+ Y Sbjct: 12 EIFDLTNKELERQCEGLEMI----ASENFTLPEVMEVMGSILTNKYAEGYPGKRYYGGCE 67 Query: 137 GITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSY 196 + E+ + K+ +A + ++G+ Q+ A+ +PGD+++ + Sbjct: 68 FVDEIETLAIERCKKLFNCKFA--NVQPNSGS-QANQGVYAALINPGDKILGMDLSHGGH 124 Query: 197 TEQARLADATPVVIPT---KISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSL 253 ++ + + + + +D + + ++ LI+C S V + Sbjct: 125 LTHGAKVSSSGKMYESCFYGVELDGRIDYEKVREIAKKEKPKLIVCGASA-YARVIDFAK 183 Query: 254 LEEIARIIAKHPRLLVLSDEIY-EHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTG 312 EIA + +D + ++ A + F Y ++ + K Sbjct: 184 FREIAD----EIGAYLFADIAHIAGLVVAGEHPSPFP-----YAHVVS-STTHKTLRGP- 232 Query: 313 WRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERR 372 R G + +A + A+G + K R Sbjct: 233 -RGGIIMTNDEELAKKINSAIFPGIQGGPLMHVIAAKAVGFKFNLSDEWKVYAKQVRTNA 291 Query: 373 DFLVKSLGDIKGVKISEPQGAFYLFIDF 400 L L D K +S+ + + F Sbjct: 292 QVLANVLMDRKFKLVSDGTDNHLVLMSF 319 >3G8M-A nrPDB Length = 417 Score = 46.6 bits (109), Expect = 3e-05, Method: Composition-based stats. Identities = 46/272 (16%), Positives = 86/272 (31%), Gaps = 33/272 (12%) Query: 128 GFTRYTLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVI 187 G Y + + + + KE G YA + +G+ Q+ A+ PGD V+ Sbjct: 61 GKRYYGGCEYVDIVEQLAIDRAKELFGADYA--NVQPHSGS-QANFAVYTALLEPGDTVL 117 Query: 188 ---IPAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCSPSNP 244 + +++ + ++P I +D DLE + E +I+ S Sbjct: 118 GMNLAHGGHLTHGSPVNFSGKLYNIVPYGIDATGHIDYADLEKQAKEHKPKMIIGGFSAY 177 Query: 245 TGSVYPKSLLEEIARIIAKHPRLLVLSDEIY------EHIIYAPATHTSFASLPDMYERT 298 +G V + + EIA I + D + + P H + Sbjct: 178 SGVV-DWAKMREIADSI----GAYLFVDMAHVAGLVAAGVYPNPVPHAHVVTTTTHK--- 229 Query: 299 LTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVA--ALGLGKA 356 + G R G + KL V G +A A+ L +A Sbjct: 230 ----------TLAGPRGGLILAKGGSEELYKKLNSAVFPGGQGGPLMHVIAGKAVALKEA 279 Query: 357 GGETVAEMVKAYRERRDFLVKSLGDIKGVKIS 388 + + +V+ + +G K+ Sbjct: 280 MEPEFKTYQQQVAKNAKAMVEVFLE-RGYKVV 310 >4GSA-A nrPDB Length = 432 Score = 45.5 bits (106), Expect = 5e-05, Method: Composition-based stats. Identities = 57/386 (14%), Positives = 119/386 (30%), Gaps = 60/386 (15%) Query: 115 KVVAEAGINAIREGFTRYTLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQ 174 V EA A+ +G + G E + ++ + S + + N ++ + Sbjct: 76 PEVIEALKVAMEKG-----TSFGAPCALENVLAEMVNDAVPSI--EMVRFVNSGTEACMA 128 Query: 175 ---AVLAVCSPGDEVIIPAPYWVSYTEQARL---ADATPVVIPTKIS-------NNFLLD 221 + A D++I + + + + + + +P+ N Sbjct: 129 VLRLMRAYTGR-DKIIKFEGCYHGHADMFLVKAGSGVATLGLPSSPGVPKKTTANTLTTP 187 Query: 222 PKDLESKLTEKSRLLILCSPSNPTGSVY------------PKSLLEEIARIIAKHPRLLV 269 DLE+ + L +P G + LE + I +H LLV Sbjct: 188 YNDLEA-----VKALFAENPGEIAGVILEPIVGNSGFIVPDAGFLEGLREITLEHDALLV 242 Query: 270 LSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACS 329 DE+ ++ + + + T + K G +G G + I+ + Sbjct: 243 F-DEV------MTGFRIAYGGVQEKFGVTPDLTTLGKIIGG-GLPVGAYGGKREIMQLVA 294 Query: 330 KLQGQVSSGA---SSIAQKAGVAALGLGKAGG--ETVAEMVKAYRERRDFLVKSLGDIKG 384 +G + +A AG+ L L + G E + ++ K D L+ + Sbjct: 295 PAGPMYQAGTLSGNPLAMTAGIKTLELLRQPGTYEYLDQITKRLS---DGLLAIAQETGH 351 Query: 385 VKISEPQGAFY-LFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVAMVPGDAFGDDSC 443 + F + E + S L++ + + P F Sbjct: 352 AACGGQVSGMFGFFFTEGPVHNYEDAKKSDLQKFSRFHRGMLEQ-GIYLAP-SQFEA-GF 408 Query: 444 IRISYATSLDVLQAAVEKIRKALEPL 469 S A + + + A + R + L Sbjct: 409 T--SLAHTEEDIDATLAAARTVMSAL 432 >3GBX-A nrPDB Length = 420 Score = 45.1 bits (105), Expect = 7e-05, Method: Composition-based stats. Identities = 57/345 (16%), Positives = 109/345 (31%), Gaps = 42/345 (12%) Query: 128 GFTRYTLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVI 187 G Y + + + + KE G YA + +G+ Q+ A+ PGD V+ Sbjct: 64 GKRYYGGCEYVDVVEQLAIDRAKELFGADYA--NVQPHSGS-QANFAVYTALLQPGDTVL 120 Query: 188 ---IPAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCSPSNP 244 + +++ + ++P I + +D ++ E +I+ S Sbjct: 121 GMNLAQGGHLTHGSPVNFSGKLYNIVPYGIDESGKIDYDEMAKLAKEHKPKMIIGGFSAY 180 Query: 245 TGSVYPKSLLEEIARIIAKHPRLLVLSDEIY------EHIIYAPATHTSFASLPDMYERT 298 +G V + + EIA I + D + + P H + Sbjct: 181 SGVV-DWAKMREIADSI----GAYLFVDMAHVAGLIAAGVYPNPVPHAHVVTTTTHK--- 232 Query: 299 LTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGG 358 + G R G + KL V A +A + A Sbjct: 233 ----------TLAGPRGGLILAKGGDEELYKKLNSAVFPSAQGGPLMHVIAGKAV--ALK 280 Query: 359 ETVAEMVKAYRERRDFLVKSLGDI---KGVKIS-EPQGAFYLFIDFSAYYGSEAEGFGLI 414 E + K Y+++ K++ ++ +G K+ +D + E Sbjct: 281 EAMEPEFKVYQQQVAKNAKAMVEVFLNRGYKVVSGGTENHLFLLDLVDKNLTGKE----A 336 Query: 415 NDSSSLALYFLDKFQVAMVPGDAFGDDSCIRI-SYATSLDVLQAA 458 + + A ++K V P F IRI S A + + A Sbjct: 337 DAALGRANITVNKNSVPNDPKSPFVTSG-IRIGSPAVTRRGFKEA 380 >4P3M-A nrPDB Length = 429 Score = 44.7 bits (104), Expect = 1e-04, Method: Composition-based stats. Identities = 60/338 (17%), Positives = 109/338 (32%), Gaps = 50/338 (14%) Query: 69 DMSLSPRVQSLKPSKTMVITDLAATLVQSGVPVIRLAAGEPDFDTPKVVAEA----GINA 124 DM+++ P ITD I L A E T V EA N Sbjct: 5 DMNIAD----YDPELWQSITDEVQRQEDH----IELIASEN--YTSPRVMEAQGSQLTNK 54 Query: 125 IREGF--TRYTLNAGITELREAIC-RKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCS 181 EG+ RY ++ E++ + K G YA + +G+ Q+ A+C+ Sbjct: 55 YAEGYPGKRYYGGCEYVDVAESLAIERAKSLFGADYA--NVQPHSGS-QANAAVYQALCA 111 Query: 182 PGDEVI---IPAPYWVSYTEQARLADATP--VVIPTKISNNFLLDPKDLESKLTEKSRLL 236 PGD ++ + +++ + V +LD ++E E + Sbjct: 112 PGDTILGMSLAHGGHLTHGSHVSFSGKMYNAVQYGITPETG-ILDYAEIERLAVEHKPTM 170 Query: 237 ILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYE 296 I+ S +G V + EIA + + D + + A + + D Sbjct: 171 IIAGFSAYSGIV-DWAKFREIADKV----GAYLFVDMAHVAGLVAAGLYPNPVPFAD--- 222 Query: 297 RTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKA------GVAA 350 + K R G + + A ++ +++S Q A Sbjct: 223 --VVTTTTHKTLGGP--RGGLI-----LAKANEAIEKKLNSAVFPGQQGGPLMHVIAAKA 273 Query: 351 LGLGKAGGETVAEMVKAYRERRDFLVKSLGDIKGVKIS 388 + + A + + +VKS +G KI Sbjct: 274 VAFKECAEPEFAVYQQQVLDNAKAMVKSFLA-RGYKIV 310 >1WYV-B nrPDB Length = 474 Score = 43.9 bits (102), Expect = 1e-04, Method: Composition-based stats. Identities = 40/246 (16%), Positives = 77/246 (31%), Gaps = 24/246 (9%) Query: 72 LSPRVQSLKP-SKTMVITDLAATLVQSGVPVIRLAAGEPDFDTPKVVAEAGINAIREGFT 130 + PR+ + + T L+ V L + ++ A + A + Sbjct: 38 VPPRLPEVDELTLVRHYTGLSRRQVGVDTTFYPLGSCTMKYNPKLHEEAARLFADLHPYQ 97 Query: 131 RYTLNAGITELREAICRKLKEENGLS-YAPDQILVSNGAKQSLLQAVLAVCSPGDE---- 185 G L + LK G+ + ++G +L G+ Sbjct: 98 DPRTAQGALRLMWELGEYLKALTGMDAITLEPAAGAHGELTGILIIRAYHEDRGEGRTRR 157 Query: 186 -VIIPAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCSPSNP 244 V++P S A +A IP+ +D + L+ +L L+L +P+ Sbjct: 158 VVLVPDSAHGSNPATASMAGYQVREIPSGPEG--EVDLEALKRELGPHVAALMLTNPN-- 213 Query: 245 TGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASL--PDMYERTLTVN 302 T ++ + +L EI+R+ E + Y A + P + Sbjct: 214 TLGLFERRIL-EISRLCK----------EAGVQLYYDGANLNAIMGWARPGDMGFDVVHL 262 Query: 303 GFSKAF 308 K F Sbjct: 263 NLHKTF 268 >3ISL-A nrPDB Length = 416 Score = 43.9 bits (102), Expect = 1e-04, Method: Composition-based stats. Identities = 43/258 (16%), Positives = 95/258 (36%), Gaps = 29/258 (11%) Query: 143 EAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSY--TEQA 200 E + + +N +Y D ++ + + +V P D+V+IP Y TE A Sbjct: 51 EMLRELFQTKNRWAYPIDGT-----SRAGIEAVLASVIEPEDDVLIPIYGRFGYLLTEIA 105 Query: 201 RLADATPVVIPTKISNNFLLDPKDLESKLTE-KSRLLILCSPSNPTGSVYPKSLLEEIAR 259 A ++ + F DP+D+ ++ + K +++ + TG ++P L+ I Sbjct: 106 ERYGANVHMLECEWGTVF--DPEDIIREIKKVKPKIVAMVHGETSTGRIHP---LKAIGE 160 Query: 260 IIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMT--GWRLGY 317 + L + D + AT D ++ + G K ++ + Y Sbjct: 161 AC-RTEDALFIVDAV--------ATIGGCEVKVDEWKIDAAIGGTQKCLSVPSGMAPITY 211 Query: 318 LAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLG---KAGGETVAEMVKAYRERRDF 374 ++AA K++ +++ A A + +E + Sbjct: 212 NERVADVIAARKKVERGIATQADRAALSGNRPITSNYFDLSQLEDYWSERRLNHHTEATT 271 Query: 375 LVKSLGDIKGVKISEPQG 392 ++ +L + GV++ +G Sbjct: 272 MLYALRE--GVRLVLEEG 287 >4Q6R-A nrPDB Length = 511 Score = 42.8 bits (99), Expect = 3e-04, Method: Composition-based stats. Identities = 44/249 (17%), Positives = 81/249 (32%), Gaps = 33/249 (13%) Query: 163 LVSNGAKQSLLQAVLAV----CSPG---DEVIIPAPYWVSYTEQARLADATPVVIPTKIS 215 V++G +S+L A A G E++ P ++ + A V +P Sbjct: 148 CVTSGGTESILMACKAYRDLAFEKGIKTPEIVAPQSAHAAFNKAASYFGMKIVRVPLTKM 207 Query: 216 NNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIY 275 +D + + ++ + +L+ +P P G + + E+A++ K+ L + + Sbjct: 208 --MEVDVRAMRRAISRNTAMLVCSTPQFPHGVI---DPVPEVAKLAVKYKIPLHVDACLG 262 Query: 276 EHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQV 335 +I A P + V G + A T + GY +V K Sbjct: 263 GFLI----VFMEKAGYPLEHPFDFRVKGVTSISADT-HKYGYAPKGSSLVLYSDKKYRNY 317 Query: 336 SSGASSIAQKA---------------GVAALGLGKAGGET-VAEMVKAYRERRDFLVKSL 379 + Q A GE E K + FL L Sbjct: 318 QFFVDTDWQGGIYASPTIAGSRPGGISAACWAALMHFGENGYVEATKQIIKTARFLKSEL 377 Query: 380 GDIKGVKIS 388 +IKG+ + Sbjct: 378 ENIKGIFVF 386 >3ECD-A nrPDB Length = 425 Score = 42.8 bits (99), Expect = 3e-04, Method: Composition-based stats. Identities = 53/356 (14%), Positives = 108/356 (30%), Gaps = 36/356 (10%) Query: 128 GFTRYTLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVI 187 G Y E+ ++K +A + +GA Q+ +LA+ PGD V+ Sbjct: 66 GKRYYGGCEFADEVEALAIERVKRLFNAGHA--NVQPHSGA-QANGAVMLALAKPGDTVL 122 Query: 188 ---IPAPYWVSYTEQARLADATPVVIPTKISNN-FLLDPKDLESKLTEKSRLLILCSPSN 243 + A +++ + L+ + +S + L+D +E+ + LI+ S Sbjct: 123 GMSLDAGGHLTHGAKPALSGKWFNALQYGVSRDTMLIDYDQVEALAQQHKPSLIIAGFSA 182 Query: 244 PTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNG 303 + IA + ++ D + + A H + + + Sbjct: 183 YP-RKLDFARFRAIADSV----GAKLMVDMAHIAGVIAAGRHANPVEHAH-----VVTST 232 Query: 304 FSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVA--ALGLGKAGGETV 361 K R G++ +A K+ V G +A A+ G+A + Sbjct: 233 THKTLRGP--RGGFVLTNDEEIAK--KINSAVFPGLQGGPLMHVIAGKAVAFGEALTDDF 288 Query: 362 AEMVKAYRERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLA 421 + L L ++ L +D A+ + + A Sbjct: 289 KTYIDRVLANAQALGDVLKAGGVDLVTGGTDNHLLLVDLRPKGLKGAQ----VEQALERA 344 Query: 422 LYFLDKFQVAMVP-------GDAFGDDSCIRISYATSLDVLQAAVEKIRKALEPLR 470 +K + P G G + + + + I + E LR Sbjct: 345 GITCNKNGIPFDPEKPTITSGIRLGTPAGTTRGFGAAE--FREVGRLILEVFEALR 398 >4OTL-A nrPDB Length = 423 Score = 42.8 bits (99), Expect = 4e-04, Method: Composition-based stats. Identities = 50/341 (14%), Positives = 107/341 (31%), Gaps = 24/341 (7%) Query: 74 PRVQSLKPSKTMVITDLAATLVQSGVPVIRLAAGEPDFDTPKVVAEAGINAIREGFTRYT 133 R QS + I + I L ++ +P V+A G + Y Sbjct: 11 DRAQSTIANVDPEIFAAIEQENRRQEDHIEL-IASENYTSPAVMAAQGSQLTNKYAEGYP 69 Query: 134 --LNAGITELREAICRKLKEENGLSYAPD--QILVSNGAKQSLLQAVLAVCSPGDEVI-- 187 G E + + + + + + + ++G+ Q+ A+ PGD ++ Sbjct: 70 GKRYYGGCEYVDVVEQLAIDRVKQLFGAEAANVQPNSGS-QANQGVFFAMLKPGDTIMGM 128 Query: 188 -IPAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTG 246 + +++ ++ V+ ++ N +D E E LI+ S Sbjct: 129 SLAHGGHLTHGSPVNMSGKWFNVVSYGLNENEDIDYDAAEKLANEHKPKLIVAGAS---- 184 Query: 247 SVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSK 306 + K E +A+I L++ Y +I A K Sbjct: 185 AFALKIDFERLAKIAKSVGAYLMVDMAHYAGLIAAGVYPNPVPHAD------FVTTTTHK 238 Query: 307 AFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVK 366 ++ G R G + + G + A+ +A E + Sbjct: 239 --SLRGPRGGVILMKAEYEKPINSAIFPGIQG-GPLMHVIAAKAVAFKEALSPEFKEYQQ 295 Query: 367 AYRERRDFLVKSLGDIKGVKISEPQ-GAFYLFIDFSAYYGS 406 E L ++L +G++I + + + +D A + + Sbjct: 296 KVVENARVLAETLVK-RGLRIVSGRTESHVMLVDLRAKHIT 335 >3NDN-A nrPDB Length = 414 Score = 42.8 bits (99), Expect = 4e-04, Method: Composition-based stats. Identities = 38/235 (16%), Positives = 72/235 (30%), Gaps = 37/235 (15%) Query: 163 LVSNGAKQSLLQAVLAVCSPGDEVIIPAPYW-----VSYTEQARLADATPVVIPTKISNN 217 + ++ ++ A+ GD ++ + V R V + Sbjct: 100 FATASGMAAVFTSLGALLGAGDRLVAARSLFGSCFVVCSEILPRW-GVQTVFVDGD---- 154 Query: 218 FLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEH 277 D E L+ ++ + +PSNP S+ + + E+A V+ D ++ Sbjct: 155 ---DLSQWERALSVPTQAVFFETPSNPMQSLVDIAAVTELAHAA----GAKVVLDNVFA- 206 Query: 278 IIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRL--GYLAGPKHIVAA-CSKLQGQ 334 T + V +K G R+ G + G + + KL Sbjct: 207 --------TPLLQQGFPLGVDVVVYSGTKHIDGQG-RVLGGAILGDREYIDGPVQKLMRH 257 Query: 335 VSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLGDIKGVKISE 389 S+ A L K G ET+A V+ + + L V+ Sbjct: 258 TGPAMSAFN------AWVLLK-GLETLAIRVQHSNASAQRIAEFLNGHPSVRWVR 305 >5YKR-A nrPDB Length = 461 Score = 42.8 bits (99), Expect = 4e-04, Method: Composition-based stats. Identities = 61/385 (15%), Positives = 114/385 (29%), Gaps = 52/385 (13%) Query: 84 TMVITDLAATLVQSGVPVIRLAAGE---PDFDTPKVVAEAGINAIREGFTRYTLNAGITE 140 + A G + A G+ VA+A R G T Sbjct: 60 LVKEAQGARVTDIDGQQYVDFALGDSGAMFGHAQPAVADAIARQARRGSTLMLPTEDSL- 118 Query: 141 LREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLA--VCSPGDEVIIPAPYW----- 193 + +L GL Y V+ A + + + S D+V++ + Sbjct: 119 ---WVGAELARRFGLPYWQ----VTTSATDANRFVLRLCRMLSGRDKVVVFNCNYHGSVD 171 Query: 194 ------VSYTEQARLADATPVVIPTKISNNF--LLDPKDLESKLTEKSRLLILCSP--SN 243 + A P + + D LE+ L +L P +N Sbjct: 172 ESQVEFDAAGRMVPRAGVHPNGVRHATTTRLVEFNDLDALEAALAHGDVAAVLTEPFMTN 231 Query: 244 PTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMY---ERTLT 300 G V P R + + + ++ DE + I PA ++ L + + + Sbjct: 232 -VGMVPPAEGFHAGLRELTRRHDVALIIDETHT-ISCGPAGYSGAHGLEPDFFVLGKCIA 289 Query: 301 VNGFSKAFAMT---GWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAG 357 S + + R+ + P G + A + Q A + A Sbjct: 290 GGIPSAVWGCSQAQAERI-WAVLPHFRPGQAINHFGFGGTLAGNALQLAAMRATFAEVMT 348 Query: 358 GETVAEMVKAYRERRDFLVKSLGDI--------KGVKISEPQGAFYLFIDFSAYYGSEAE 409 + M + + + +L ++ G ++ YLF+ + G EA Sbjct: 349 EDAYRHMFQLAAQLEAGVRATLEELRLPWHVTRIGARVE------YLFMTHAPRNGGEAH 402 Query: 410 GFGLINDSSSLALYFLDKFQVAMVP 434 + L LY L++ V + P Sbjct: 403 HARNGLIEACLHLYLLNR-GVLLTP 426 >4J5U-A nrPDB Length = 420 Score = 42.8 bits (99), Expect = 4e-04, Method: Composition-based stats. Identities = 44/334 (13%), Positives = 100/334 (29%), Gaps = 40/334 (11%) Query: 86 VITDLAATLVQSGVPVIRLAAGEPDFDTPKVVAEAGINAIREGFTRYTLNA---GITELR 142 I ++ VI L +F +P V+ G + Y G E+ Sbjct: 14 EINEIIKHEKLRQSSVIEL-IASENFVSPAVLEAQGALLTNKYAEGYPSKRFYNGCEEVD 72 Query: 143 EA---ICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVI---IPAPYWVSY 196 +A ++K+ YA + +G+ Q+ LA+ PGD V+ + + +++ Sbjct: 73 KAENLAIERVKKLFNCKYA--NVQPHSGS-QANQAVYLALLQPGDTVLGMSLDSGGHLTH 129 Query: 197 TEQARLADATPVVI-PTKISNNFLLDPKDLESKLTEKSRLLIL----CSPSNPTGSVYPK 251 ++ + + +L+D ++E L++ P N Sbjct: 130 GAAPNMSGKWFNAVSYSVNKETYLIDYDEIERLADLHKPKLLIAGFSAYPRN-----IDF 184 Query: 252 SLLEEIARIIAKHPRLLVLSDEIY-EHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAM 310 + EI + ++D + ++ + Y +T + K Sbjct: 185 AKFREIVDKV----GAYFMADIAHIAGLVATGEHQSPIP-----YAHAVT-STTHKTLRG 234 Query: 311 TGWRLGYLAGPKHIVAACSKLQGQVSSGA--SSIAQKAGVAALGLGKAGGETVAEMVKAY 368 R G + + K+ + G + A+ + ++ Sbjct: 235 P--RGGLILSNDEEIGH--KINSALFPGLQGGPLMHIIAAKAVAFLENLQPEYKSYIQQV 290 Query: 369 RERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSA 402 L SL + ++ + +D Sbjct: 291 ISNAKALASSLQERGYDILTGGTDNHIVLVDLRK 324 >2CB1-A nrPDB Length = 412 Score = 42.0 bits (97), Expect = 6e-04, Method: Composition-based stats. Identities = 36/211 (17%), Positives = 76/211 (36%), Gaps = 34/211 (16%) Query: 123 NAIREGFTRYTLNAGITELRE------AICRKLKEENGLSYAPDQILVSNGAKQSLLQAV 176 + EG R+ G R+ A+ +LK G + +++++G + + A+ Sbjct: 33 KTLEEGQERFATGEGYVYARQKDPTAKALEERLKALEGAL---EAVVLASG-QAATFAAL 88 Query: 177 LAVCSPGDEVIIPAPYWVS----YTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEK 232 LA+ PGDEV+ + + + L T + +P+ + L+ K Sbjct: 89 LALLRPGDEVVAAKGLFGQTIGLFGQVLSLMGVTVRYVD--------PEPEAVREALSAK 140 Query: 233 SRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLP 292 +R + + + +NP V L + A+ + ++ D + P Sbjct: 141 TRAVFVETVANPALLVPDLEALATL----AEEAGVALVVDNTFGA--------AGALCRP 188 Query: 293 DMYERTLTVNGFSKAFAMTGWRLGYLAGPKH 323 + + V +K + G LG + Sbjct: 189 LAWGAHVVVESLTKWASGHGSVLGGAVLSRE 219 >2CH1-A nrPDB Length = 396 Score = 41.6 bits (96), Expect = 8e-04, Method: Composition-based stats. Identities = 44/246 (17%), Positives = 79/246 (32%), Gaps = 41/246 (16%) Query: 162 ILVSNGAKQSLLQAVLAVCSPGDEVIIP-APYWVS-YTEQARLADATPVVIPTKISNNFL 219 + VS A + + + GD V+I W E + A I F Sbjct: 72 MCVSGSAHAGMEAMLSNLLEEGDRVLIAVNGIWAERAVEMSERYGADVRTIEGPPDRPFS 131 Query: 220 LDPKDLESKLT-EKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLS------- 271 L + L + + + L L + +G + P LE + +I +H LL++ Sbjct: 132 L--ETLARAIELHQPKCLFLTHGDSSSGLLQP---LEGVGQICHQHDCLLIVDAVASLCG 186 Query: 272 ----------DEIY---EHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLG-- 316 D +Y + ++ AP T + P + SK F LG Sbjct: 187 VPFYMDKWEIDAVYTGAQKVLGAPPGITPISISPKALDVIRNRRTKSKVFYWDLLLLGNY 246 Query: 317 YLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLV 376 + + + + + ++AQ A E + +K E L Sbjct: 247 WGCYDEPKRYHHTVASNLIFALREALAQIA-----------EEGLENQIKRRIECAQILY 295 Query: 377 KSLGDI 382 + LG + Sbjct: 296 EGLGKM 301 >2CTZ-A nrPDB Length = 421 Score = 40.9 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 52/329 (15%), Positives = 111/329 (33%), Gaps = 47/329 (14%) Query: 111 FDTPKVVAEAGINAIREGFTRYTLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQ 170 F +P+ A + A++E Y+ + + + ++L G A L + Sbjct: 33 FKSPEHA--ANLFALKEFGNIYSRI--MNPTVDVLEKRLAALEGGKAA----LATASGHA 84 Query: 171 SLLQAVLAVCSPGDEVI-IPAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKL 229 + A+ + GD ++ P Y ++ + + + P++ + Sbjct: 85 AQFLALTTLAQAGDNIVSTPNLYGGTFNQFKVTLKRLGIEVRFTSREE---RPEEFLALT 141 Query: 230 TEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFA 289 EK+R + S NP ++ L + A+ + ++ D + Y Sbjct: 142 DEKTRAWWVESIGNPALNIPDLEALAQ----AAREKGVALIVDNTFGMGGY--------L 189 Query: 290 SLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVA 349 P + L + +K ++ G ++A G + G Sbjct: 190 LRPLAWGAALVTHSLTK----------WVGGHGAVIAGAIVDGGNFPW-------EGGRY 232 Query: 350 ALGLGKAGGETVAEMVKAYRERRDFLVKSLGDIKGVKISEPQ-GAFYLFIDFSAYYGSEA 408 L G + +A+ E F+VK+ + G++ G F ++ Sbjct: 233 PLLTEPQPGYHGLRLTEAFGE-LAFIVKA--RVDGLRDQGQALGPFEAWVVLLGMETLSL 289 Query: 409 EGFGLINDSSSLALYFLDKFQVAMV--PG 435 + ++ LA + L++ QVA V PG Sbjct: 290 RAERHVENTLHLAHWLLEQPQVAWVNYPG 318 >4E3Q-A nrPDB Length = 473 Score = 39.3 bits (90), Expect = 0.003, Method: Composition-based stats. Identities = 36/261 (13%), Positives = 77/261 (29%), Gaps = 21/261 (8%) Query: 224 DLESKLTEK---SRLLILCSPSNPTGSVYPKS--LLEEIARIIAKHPRLLVLSDEIYEHI 278 +LE + + + P G V P + + I I+ K+ + V+SDE+ Sbjct: 224 ELEETIQREGADTIAGFFAEPVMGAGGVIPPAKGYFQAILPILRKY-DIPVISDEVICGF 282 Query: 279 IYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSG 338 T D + SK + +G + + + Sbjct: 283 GRTGNTWGCVT--YDFTPDAIIS---SKNLTAGFFPMGAVILGPELSKRLETAIEAIEEF 337 Query: 339 ASSIAQKA-----GVAALGLGKAGGETVAEMVKAYRERRDFLVKSLGDIKGVKISEPQGA 393 +A + E +AE V+ R + +K + + + G Sbjct: 338 PHGFTASGHPVGCAIALKAIDVVMNEGLAENVRRLAPRFEERLKHIAERPNIGEYRGIG- 396 Query: 394 FYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVAMVPGDAFGDDSCIRISYATSLD 453 +++ + + F S + P G + + + Sbjct: 397 -FMWALEAVKDKASKTPFDGNLSVSERIANTCTDLGLICRP---LGQSVVLCPPFILTEA 452 Query: 454 VLQAAVEKIRKALEPLRATVS 474 + +K+ KAL+ + A V+ Sbjct: 453 QMDEMFDKLEKALDKVFAEVA 473 >5VMB-A nrPDB Length = 425 Score = 39.3 bits (90), Expect = 0.004, Method: Composition-based stats. Identities = 43/259 (16%), Positives = 92/259 (35%), Gaps = 22/259 (8%) Query: 128 GFTRYTLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVI 187 G Y + + + + KE G YA + G+ Q+ LA+ +PGD V+ Sbjct: 68 GKRYYGGCEFVDVIEQMAIDRAKELFGADYA--NVQPHAGS-QANSAVYLALLNPGDTVL 124 Query: 188 ---IPAPYWVSYTEQARLADATPVVIPTKI-SNNFLLDPKDLESKLTEKSRLLILCSPSN 243 + +++ + + T + + + +D +++E E +I+ S Sbjct: 125 GMSLAHGGHLTHGAKVSFSGKTYNAVQYGLNAETGEIDYEEVERLALEHKPRMIVAGFSA 184 Query: 244 PTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNG 303 + V +IA + + D + + A + + + D +T Sbjct: 185 YS-RVVDWQRFRDIADKV----GAYLFVDMAHVAGLVAAGVYPNPVQIAD-----VTTTT 234 Query: 304 FSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAE 363 K R G + K KLQ V G +AA + E +++ Sbjct: 235 THKTLRGP--RSGLILA-KANEEIEKKLQSAVFPGNQGGPLMHAIAAKAI--CFKEAMSD 289 Query: 364 MVKAYRERRDFLVKSLGDI 382 KAY+++ +++ ++ Sbjct: 290 DFKAYQQQVVKNAQAMAEV 308 >3A9Z-A nrPDB Length = 432 Score = 38.9 bits (89), Expect = 0.005, Method: Composition-based stats. Identities = 57/316 (18%), Positives = 105/316 (33%), Gaps = 64/316 (20%) Query: 115 KVVAEAGINAIREGFTRYTLNAGITEL----REAICRKLKEENGLSYAPDQILVSNGAKQ 170 + V EA A + Y ++ R ++ + + P I+ ++G + Sbjct: 36 QAVTEAMKEAWGNPSSSYVAGRKAKDIINTARASLAKMIGG------KPQDIIFTSGGTE 89 Query: 171 SLLQAVLAVCS--------PGDEV--IIPA----PYWV-----------SYTEQARLADA 205 S + + G V I P P+++ A Sbjct: 90 SNNLVIHSTVRCFHEQQTLQGRTVDQISPEEGTRPHFITCTVEHDSIRLPLEHLVEDQVA 149 Query: 206 TPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEE------IAR 259 +P N ++ +D+ + + + L+ + +N TG + P S + R Sbjct: 150 EVTFVPVSKVNG-QVEVEDILAAVRPTTCLVTIMLANNETGVIMPISEISRRIKALNQIR 208 Query: 260 IIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLG--Y 317 + PR+LV +D L + LT+ G K + G R+G Y Sbjct: 209 AASGLPRVLVHTDAAQAL----GKRRVDVEDLGVDF---LTIVG-HKFY---GPRIGALY 257 Query: 318 LAGPKHIVAACSKL--QGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAY----RER 371 + G + L GQ + +A LG + V+E + Y R+ Sbjct: 258 VRGVGKLTPLYPMLFGGGQERNFRPGTENTPMIAGLG---KAADLVSENCETYEAHMRDI 314 Query: 372 RDFLVKSLGDIKGVKI 387 RD+L + L G +I Sbjct: 315 RDYLEERLEAEFGKRI 330 >3HBX-A nrPDB Length = 502 Score = 38.6 bits (88), Expect = 0.006, Method: Composition-based stats. Identities = 37/264 (14%), Positives = 87/264 (32%), Gaps = 42/264 (15%) Query: 165 SNGAKQSLLQAVLAV-----------CSPGDE--VIIPAPYWVSYTEQARLADATPVVIP 211 + G+ ++++ A LA P D+ ++ A V + + AR + + Sbjct: 123 TVGSSEAIMLAGLAFKRKWQNKRKAEGKPVDKPNIVTGANVQVCWEKFARYFEVELKEVK 182 Query: 212 TKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHP--RLLV 269 +++DP+ + E + + S G LL ++ K + Sbjct: 183 LS-EGYYVMDPQQAVDMVDENTICVAAILGSTLNGEFEDVKLLNDLLVEKNKETGWDTPI 241 Query: 270 LSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWR-------LGYLA--- 319 D + F ++ L + K+ ++G + +G++ Sbjct: 242 HVDAA------SGGFIAPFLYPELEWDFRLPLV---KSINVSGHKYGLVYAGIGWVIWRN 292 Query: 320 ---GPKHIVAACSKL---QGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRD 373 P+ ++ + L Q + S + + L + G E +++ RE Sbjct: 293 KEDLPEELIFHINYLGADQPTFTLNFSKGSSQVIAQYYQLIRLGHEGYRNVMENCRENMI 352 Query: 374 FLVKSLGDIKGVKIS-EPQGAFYL 396 L + L + I + +G + Sbjct: 353 VLREGLEKTERFNIVSKDEGVPLV 376 >4WXB-A nrPDB Length = 428 Score = 38.2 bits (87), Expect = 0.007, Method: Composition-based stats. Identities = 51/356 (14%), Positives = 110/356 (30%), Gaps = 30/356 (8%) Query: 121 GINAIREGF--TRYTLNAGITELREAIC-RKLKEENGLSYAPDQILVSNGAKQSLLQAVL 177 N EG+ RY + ++ E + + K+ G +A + +G+ Q+ + Sbjct: 63 LTNKYAEGYPGKRYYGGTAVIDVVETLAIERAKKLFGAKFA--NVQPHSGS-QANAAVYM 119 Query: 178 AVCSPGDEVI---IPAPYWVSYTEQARLADATPVVIPTKIS-NNFLLDPKDLESKLTEKS 233 ++ PGD V+ + A +++ + T + + + LLD + ++ E Sbjct: 120 SLIQPGDTVMGMDLSAGGHLTHGAPVSFSGKTYNFVSYNVDKESELLDYDAILAQAKEVR 179 Query: 234 RLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPD 293 LI+ S + + + EIA + ++ D + + A H S Sbjct: 180 PKLIVAGASAYS-RIIDFAKFREIADAV----GAYLMVDMAHIAGLVASGHHPSPVPYAH 234 Query: 294 MYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGL 353 +T K R G + +A + A+ L Sbjct: 235 -----VTTTTTHKTLRGP--RGGLILTDDEDIAKKLNSAVFPGLQGGPLEHVIAAKAVAL 287 Query: 354 GKAGGETVAEMVKAYRERRDFLVKSLGDIKGVKIS-EPQGAFYLFIDFSAYYGSEAEGFG 412 +A E + + + ++ +D + E Sbjct: 288 KEALDPAFKEYGENVIKNAAAMADVFNQHPDFRVISGGTNNHLFLVDVTKV----VENGK 343 Query: 413 LINDSSSLALYFLDKFQVAMVPGDAFGDDSCIRIS--YATSLDVLQAAVEKIRKAL 466 + + L+K + F IR+ TS + +A +I + + Sbjct: 344 VAQNVLEEVNITLNKNSIPYEQLSPFKTSG-IRVGSPAITSRGMGEAESRQIAEWM 398 >3L44-A nrPDB Length = 434 Score = 37.8 bits (86), Expect = 0.011, Method: Composition-based stats. Identities = 47/341 (13%), Positives = 101/341 (29%), Gaps = 36/341 (10%) Query: 115 KVVAEAGINAIREGFTRYTLNAGITELREAICRKLKEENGLSYAP---DQILVSNGAKQS 171 + +A A G T A + + + + + + + + ++ + ++ Sbjct: 74 PHITKAITTAAENGVLYGTPTALEVKFAKMLKEAMPALDKVRFVNSGTEAVMTTIRVARA 133 Query: 172 ------LLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADA------TPVVIPTKISNNFL 219 +++ D V++ A S A + +P Sbjct: 134 YTGRTKIMKFAGCYHGHSDLVLVAAGSGPSTLGTPDSAGVPQSIAQEVITVPFNNVETLK 193 Query: 220 LDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHII 279 ++ I+ + G V PK E + LV+ DE+ Sbjct: 194 EALDKWGHEVAAILVEPIVGN----FGIVEPKPGFLEKVNELVHEAGALVIYDEVITAFR 249 Query: 280 Y-APATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQG--QVS 336 + PD + K G +G G K I+ + L Q Sbjct: 250 FMYGGAQDLLGVTPD-------LTALGKVIGG-GLPIGAYGGKKEIMEQVAPLGPAYQAG 301 Query: 337 SGASSIAQKA-GVAALGLGKAGG--ETVAEMVKAYRERRDFLVKSLGDIKGVKISEPQGA 393 + A + A A G+A L + + G E + E+ + L ++ + ++ +GA Sbjct: 302 TMAGNPASMASGIACLEVLQQEGLYEKLDELGATLE--KGILEQAAKHNIDITLNRLKGA 359 Query: 394 FYLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVAMVP 434 ++ + +A L + V + P Sbjct: 360 LTVYFTTNTIEDYDAAQDTDGEMFGKFFKLMLQE-GVNLAP 399 >3HQT-A nrPDB Length = 409 Score = 37.8 bits (86), Expect = 0.011, Method: Composition-based stats. Identities = 39/233 (16%), Positives = 73/233 (31%), Gaps = 41/233 (17%) Query: 245 TGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGF 304 G++ P + L I +K +L DE + + P A L E Sbjct: 199 LGTIAPLAELVNI----SKEFGCALLVDESHSLGTHGPNGAGLLAELGLTREVHFMTASL 254 Query: 305 SKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEM 364 +K FA +R G + + + ++ + +A G ET E+ Sbjct: 255 AKTFA---YRAGAIWCNNEVNRCVPFISYPAIFSSTLLPYEAA---------GLETTLEI 302 Query: 365 VKAYRERR---DFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLA 421 +++ RR D + + L G+ + + G ++ + Sbjct: 303 IESADNRRQHLDRMARKLR--IGLSQLG--------LTIRSESQIIGLETGDERNTEKVR 352 Query: 422 LYFLDKFQVAMVPGDAFGDD------SCIRISYATSLDVLQAAVEKIRKALEP 468 Y + V G F + IR+S + DV + KI + Sbjct: 353 DYL-ESNGVF---GSVFCRPATSKNKNIIRLSL--NSDVNDEQIAKIIEVCSD 399 >4EB7-A nrPDB Length = 382 Score = 37.8 bits (86), Expect = 0.012, Method: Composition-based stats. Identities = 24/160 (15%), Positives = 59/160 (36%), Gaps = 19/160 (11%) Query: 112 DTPKVVAEAGINAIREGF------TRYT--LNAGITELREAICRKLKEENGLSYAPDQIL 163 + + EA + + E F Y + E RE + + + G ++ Sbjct: 11 PVDERILEAMLPYMTESFGNPSSVHSYGFKAREAVQEAREKVAKLVNGGGGT------VV 64 Query: 164 VSNGAKQSLLQAVLAV----CSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNNF- 218 ++GA ++ A++ G +++ A +S A+ + + Sbjct: 65 FTSGATEANNLAIIGYAMRNARKGKHILVSAVEHMSVINPAKFLQKQGFEVEYIPVGKYG 124 Query: 219 LLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIA 258 +D ++ KL + + L+ + +N G++ P + E+ Sbjct: 125 EVDVSFIDQKLRDDTILVSVQHANNEIGTIQPVEEISEVL 164 >2EZ1-A nrPDB Length = 456 Score = 37.4 bits (85), Expect = 0.012, Method: Composition-based stats. Identities = 42/274 (15%), Positives = 81/274 (29%), Gaps = 22/274 (8%) Query: 148 KLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADATP 207 L+ + I+ ++ + + PG V Y+ + A Sbjct: 79 HLERTVQELFGFKHIVPTHQGRGAENLLSQLAIKPGQYVAGNM-YFTTTRYHQEKNGAVF 137 Query: 208 VVIPTKISNNFL--------LDPKDLESKLTEK----SRLLILCSPSNPTG-SVYPKSLL 254 V I +++ +D K L+ + EK + L N G + + Sbjct: 138 VDIVRDEAHDAGLNIAFKGDIDLKKLQKLIDEKGAENIAYICLAVTVNLAGGQPVSMANM 197 Query: 255 EEIARIIAKHPRLLVLSDEIYE-HIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGW 313 + + H + V D Y + E + ++ M+G Sbjct: 198 RAVRELTEAH-GIKVFYDATRCVENAYFIKEQEQGFENKSIAEIVHEMFSYADGCTMSGK 256 Query: 314 R------LGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKA 367 + G+L + + +K V G S AG + E + Sbjct: 257 KDCLVNIGGFLCMNDDEMFSSAKELVVVYEGMPSYGGLAGRDMEAMAIGLREAMQYEYIE 316 Query: 368 YRERRDFLVKSLGDIKGVKISEPQGAFYLFIDFS 401 +R ++ + GV I EP G +F+D Sbjct: 317 HRVKQVRYLGDKLKAAGVPIVEPVGGHAVFLDAR 350 >1Z7D-A nrPDB Length = 433 Score = 37.4 bits (85), Expect = 0.014, Method: Composition-based stats. Identities = 24/164 (14%), Positives = 57/164 (34%), Gaps = 18/164 (10%) Query: 221 DPKDLESKLTEKSRLLILCSP-SNPTGSVYPKS-LLEEIARIIAKHPRLLVLSDEIYEHI 278 D + LE +L + + + P G + P L+ + I K+ +L ++DE+ + Sbjct: 200 DLEALEEELKDPNVCAFIVEPIQGEAGVIVPSDNYLQGVYDICKKY-NVLFVADEVQTGL 258 Query: 279 IYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSG 338 ++ + + KA + + + + I+ + + G Sbjct: 259 GRTGKL--LCVHHYNVKPDVILLG---KALSGGHYPISAVLANDDIMLVIKPGEHGSTYG 313 Query: 339 ASSIAQKAGVAAL----------GLGKAGGETVAEMVKAYRERR 372 + +A V AL K GG + + + ++ + Sbjct: 314 GNPLAASICVEALNVLINEKLCENAEKLGGPFLENLKRELKDSK 357 >3NNK-A nrPDB Length = 411 Score = 37.0 bits (84), Expect = 0.020, Method: Composition-based stats. Identities = 32/190 (16%), Positives = 60/190 (31%), Gaps = 25/190 (13%) Query: 85 MVITDLAATLVQSGVPVIRLAAGEPDFDTPKVVAEAGINAIREGFTRYTLNAGITELREA 144 M IT + S RL G + V A + + +Y +T Sbjct: 1 MDITQFSQLNPPS-----RLLMGPGPINADPRVLRAMSSQL---IGQYDPA--MTHYMNE 50 Query: 145 ICRKLKEENGLSYAPDQILVSNGAK-QSLLQAVLAVCSPGDEVIIPAPYWVSYTE----Q 199 + + ++ +G + +++ PGD+V++ P + + Sbjct: 51 VMALYRGVFRTENR--WTMLVDGTSRAGIEAILVSAIRPGDKVLV--PVFGRFGHLLCEI 106 Query: 200 ARLADATPVVIPTKISNNFLLDPKDLESKLTE-KSRLLILCSPSNPTGSVYPKSLLEEIA 258 AR A I F D +E + + RLL+ T + L E+ Sbjct: 107 ARRCRAEVHTIEVPWGEVFTPD--QVEDAVKRIRPRLLLTVQGD--TSTTM-LQPLAELG 161 Query: 259 RIIAKHPRLL 268 I ++ L Sbjct: 162 EICRRYDALF 171 >3WKR-A nrPDB Length = 416 Score = 36.6 bits (83), Expect = 0.021, Method: Composition-based stats. Identities = 30/204 (14%), Positives = 67/204 (32%), Gaps = 24/204 (11%) Query: 138 ITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPY-WVSY 196 I + E I + L + ++GA++ + A+C GD V++ + SY Sbjct: 99 IKDFLEDIAKFLNMDCARP--------THGAREGKFIVMHAICKEGDYVVLDKNAHYTSY 150 Query: 197 TEQARL-ADATPVVIPTKISNNFLLDPKDLESKLT---EKSRLLILCSPSNPTGSVYPKS 252 R + V + + ++ + + + +K + + L ++ G + Sbjct: 151 VAAERAKLNVAEVGYE-EEYPTYKINLEGYKEVIDNLEDKGKNVGLILLTHVDGEYGNLN 209 Query: 253 LLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTG 312 +++ +I K + L + Y T + V K+ A Sbjct: 210 DAKKVGKIA-KEKGIPFLLNCAY--------TVGRMPVNGKEVKADFIVASGHKSMA-AS 259 Query: 313 WRLGYLAGPKHIVAACSKLQGQVS 336 G LA + +K + Sbjct: 260 APCGILAFSEEFSDKITKTSEKFP 283 >2FQ6-A nrPDB Length = 415 Score = 36.2 bits (82), Expect = 0.027, Method: Composition-based stats. Identities = 49/332 (14%), Positives = 111/332 (33%), Gaps = 47/332 (14%) Query: 71 SLSPRVQSLKPSKTMVITDLAATLVQSGVPVIRLAAGEPDFDTPKVVAEAGINAIREGFT 130 L PR + K A + + + + + EA +A R Sbjct: 13 GLVPRGSHMADKKLDTQLVNAGRSKKYTLGAVN-SVIQRASSLVFDSVEAKKHATRNRAN 71 Query: 131 R---YTLNAGIT--ELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDE 185 Y +T L++A+C E G +L GA ++ ++LA GD Sbjct: 72 GELFYGRRGTLTHFSLQQAMCEL---EGGAGC----VLFPCGA-AAVANSILAFIEQGDH 123 Query: 186 VIIPAPYWVSYTEQARLADATPVVIPTKISNNFLLDP--KDLESKLTEKSRLLILCSPSN 243 V++ + + ++ ++ ++ D+ L ++++ L SP + Sbjct: 124 VLMTNTAYEPSQDFCS-----KILSKLGVTTSWFDPLIGADIVKHLQPNTKIVFLESPGS 178 Query: 244 PTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNG 303 T V+ + R + P +++ D + + F +L + +++ Sbjct: 179 ITMEVHDVPAIVAAVRSVV--PDAIIMIDNTWAAGVL-------FKALD--FGIDVSIQA 227 Query: 304 FSKAFAMTGWRLGYLAGPKHIVAA----CSKLQGQVSSGASSIAQKAGVAALGLGKAGGE 359 +K YL G + ++ Q+ A + Q + G Sbjct: 228 ATK----------YLVGHSDAMIGTAVCNARCWEQLRENAYLMGQMVDADTAYITSRGLR 277 Query: 360 TVAEMVKAYRERRDFLVKSLGDIKGV-KISEP 390 T+ ++ + E + + L + V +++ P Sbjct: 278 TLGVRLRQHHESSLKVAEWLAEHPQVARVNHP 309 >1C7G-A nrPDB Length = 456 Score = 36.2 bits (82), Expect = 0.028, Method: Composition-based stats. Identities = 40/283 (14%), Positives = 88/283 (31%), Gaps = 22/283 (7%) Query: 148 KLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADATP 207 L++ + I+ ++ + + PG V Y+ + AT Sbjct: 79 HLEKTVKELFGFKHIVPTHQGRGAENLLSQLAIKPGQYVAGNM-YFTTTRFHQEKNGATF 137 Query: 208 VVIPTKISNN--------FLLDPKDLESKLTEK----SRLLILCSPSNPTG-SVYPKSLL 254 V I +++ +D L + + EK + L N G + + Sbjct: 138 VDIVRDEAHDASLNLPFKGDIDLNKLATLIKEKGAENIAYICLAVTVNLAGGQPVSMANM 197 Query: 255 EEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWR 314 + + + + + Y + + + + ++ M+G + Sbjct: 198 RAVHEMASTYGIKIFYDATRCVENAYFIKEQEAGYENVSIKDIVHEMFSYADGCTMSGKK 257 Query: 315 ------LGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVA-EMVKA 367 G+L + + +K V G S AG + E + E ++ Sbjct: 258 DCLVNIGGFLCMNDEEMFSAAKELVVVYEGMPSYGGLAGRDMEAMAIGLREAMQYEYIEH 317 Query: 368 YRERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEG 410 ++ +L L + GV I EP G +F+D + + Sbjct: 318 RVKQVRYLGDKLREA-GVPIVEPTGGHAVFLDARRFCPHLTQD 359 >4IW7-A nrPDB Length = 399 Score = 35.9 bits (81), Expect = 0.040, Method: Composition-based stats. Identities = 55/360 (15%), Positives = 112/360 (31%), Gaps = 50/360 (13%) Query: 121 GINAIREGFTRYTL-NAG---ITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAV 176 +AI GF +Y + G + + + E P I S+G + L Sbjct: 70 LKHAIVNGFDKYGFGSKGSNIVCGYTDETQQFEHEFAKFINYPRAIFFSSGFM-ANLAIY 128 Query: 177 LAVCSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLL 236 + S D + S + +L+ A + + + K + + Sbjct: 129 STLFSKHDSIFADKYIHASIIDGIKLSQAKLRRYKHQQLSQLQ---DIYDGKSFITTEGV 185 Query: 237 ILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYE 296 S GS+ + L+++A+I + ++ DE + + + S Y+ Sbjct: 186 FSTS-----GSI---TQLDKLAKITPEK----LIVDEAHSFGVLGKNGRGAINSFRISYK 233 Query: 297 R-TLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGK 355 + V KAF +G + +A + +++ AAL K Sbjct: 234 NCLICVFPLGKAFGG----VGAVVCTTEAIAEYLIQFARNYIYTTALPPMILKAALIQLK 289 Query: 356 AGGETVAEMVKAYRERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLIN 415 E V + ++ F L D K +++ + N Sbjct: 290 N-LENVNDNRARLQQNITFF-NELCDAKDLELVS-----------KDLSPIRSIQLNNAN 336 Query: 416 DSSSLALYFLDKFQVAMVPGDAFGDDS------CIRISYATSL--DVLQAAVEKIRKALE 467 + L + + F + +R S ++ D +Q A+E I K ++ Sbjct: 337 LAIRLKDKLFENKIIV----SCFRYPTVPKDQAILRFSLHSNNTFDQIQQALEIISKEVK 392 >3MC6-C nrPDB Length = 497 Score = 35.9 bits (81), Expect = 0.043, Method: Composition-based stats. Identities = 42/299 (14%), Positives = 87/299 (29%), Gaps = 51/299 (17%) Query: 172 LLQAVLAVCSPG---DEVIIPAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESK 228 L + A+ G E+I P + + A + + + +D ++ Sbjct: 144 LSAKMYALHHRGITEPEIIAPVTAHAGFDKAAYYFGMKLRHVELDPTT-YQVDLGKVKKF 202 Query: 229 LTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSF 288 + + + LL+ +P+ P G +E + +I K+ +L + D I + + Sbjct: 203 INKNTVLLVGSAPNFPHGI---ADDIEGLGKIAQKY-KLPLHVDSCLGSFIVSFMEKAGY 258 Query: 289 ASLPDMYERTLTVNGFS---KAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQK 345 +LP + R V S + G I+ S L+ Q Sbjct: 259 KNLPLLDFRVPGVTSISCDTHKYGFAPK------GSSVIMYRNSDLRMH---------QY 303 Query: 346 AGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYG 405 A G G T+A G + G Sbjct: 304 YVNPAWTGGLYGSPTLAGSR-----------------PGAIVVGCWATMVNM----GENG 342 Query: 406 SEAEGFGLINDSSSLALYFLDKFQVAMVPGDAFGDDSCIRISYATSLDVLQAAVEKIRK 464 ++ + Y + + D G+ IS+++ + +++ K Sbjct: 343 YIESCQEIVGAAMKFKKYIQEN----IPDLDIMGNPRYSVISFSSKTLNIHELSDRLSK 397 >5GHG-A nrPDB Length = 456 Score = 34.7 bits (78), Expect = 0.097, Method: Composition-based stats. Identities = 38/250 (15%), Positives = 90/250 (36%), Gaps = 25/250 (10%) Query: 137 GITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVI-IPAPYWVS 195 G E R+ I + + +G++ +++ + L + P D ++ P++ Sbjct: 137 GEPE-RKKIISRKRGYHGVT-------IASASLTGLPNNHRSFDLPIDRILHTGCPHF-- 186 Query: 196 YTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCSPS-NPTGSVYPKSLL 254 Y E A + T++++ + + L + + P G V P Sbjct: 187 YREG--QAGESEEQFATRLAD----ELEQLIIAEGPHTIAAFIGEPVMGAGGVVVPPKTY 240 Query: 255 EEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWR 314 E + + K +L+++DE+ S DM L SK + + Sbjct: 241 WEKVQAVLKRYDILLIADEVICGFGRTGNLFGS--QTFDMKPDILV---MSKQLSSSYLP 295 Query: 315 LGYLAGPKHIVAACSKLQGQVSSGAS--SIAQKAGVAALGLGKAGGETVAEMVKAYRERR 372 + + + A ++ ++ + + + + AA+ L ++V R+R Sbjct: 296 ISAFLINERVYAPIAEESHKIGTLGTGFTASGHPVAAAVALENLAIIEERDLVANARDRG 355 Query: 373 DFLVKSLGDI 382 ++ K L ++ Sbjct: 356 TYMQKRLREL 365 >1VJO-A nrPDB Length = 393 Score = 33.9 bits (76), Expect = 0.14, Method: Composition-based stats. Identities = 55/356 (15%), Positives = 114/356 (32%), Gaps = 41/356 (11%) Query: 133 TLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPY 192 L+ L + I L + P I VS ++ + PGD V+I Sbjct: 60 HLDPAFLALMDEIQSLL-RYVWQTENPLTIAVSGTGTAAMEATIANAVEPGDVVLIGVAG 118 Query: 193 WVSYTEQARLADATPVVIPTKISN-NFLLDPKDLESKL-TEKSRLLILCSPSNPTGSVYP 250 + +A + T + ++L + L T + +L L TG+ Sbjct: 119 YFG-NRLVDMAGRYGADVRTISKPWGEVFSLEELRTALETHRPAILALVHAETSTGA--- 174 Query: 251 KSLLEEIARIIAKHPRLLVLS------------DEIYEHIIYAPATHTSFASLPDMYERT 298 + LE + + + LL++ D + Y+ + P T Sbjct: 175 RQPLEGVGELCREFGTLLLVDTVTSLGGVPIFLDAWGVDLAYS-CSQKGLGCSPGASPFT 233 Query: 299 LTVNGFSKAF----AMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLG 354 ++ K + W L +++ + A A AL L Sbjct: 234 MSSRAIEKLQRRRTKVANWYL-----DMNLLGKYWGSERVYHHTAPINLYYALREALRL- 287 Query: 355 KAGGETVAEMVKAYRERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLI 414 E +A + +++ ++L + L DI G+ + + Y + + Sbjct: 288 -IAQEGLANCWQRHQKNVEYLWERLEDI-GLSLHVEKE--YRLPTLTTVCIPDGV----- 338 Query: 415 NDSSSLALYFLDKFQVAMVPGDAFGDDSCIRISYATSLDVLQAAVEKIRKALEPLR 470 D ++A L++ + + G R+ + +V+++ ALE + Sbjct: 339 -DGKAVARRLLNEHNIEVGGGLGELAGKVWRVGLMGFNSR-KESVDQLIPALEQVL 392 >5Z8A-A nrPDB Length = 437 Score = 33.5 bits (75), Expect = 0.22, Method: Composition-based stats. Identities = 32/175 (18%), Positives = 52/175 (29%), Gaps = 24/175 (13%) Query: 134 LNAGITELREAICRKLKEENGLSYAPDQIL---------VSNGAKQSLLQAVLAVC---- 180 L G E+ EAI R + +G+ A +L V G L + A Sbjct: 76 LGHGDEEVAEAIARAARGRSGVGTAWSPVLDSLLGQLQEVCGGDVVGLYRTGTAALRSVT 135 Query: 181 ----SPGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLES-KLTEKSRL 235 D I+ + + Y P FL D L + Sbjct: 136 CAVRDARDRSIVLSSGYHGYDPM--WHCDEPFTPNQHGIVEFLFDLDVLAEWLSRPEQVA 193 Query: 236 LILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFAS 290 ++ SP + + E R+ K + V++DE+ + Y T Sbjct: 194 AVVISPDH---MHLGERWYTEFTRLT-KEADVPVIADEVKVGLRYRAGLSTPLLD 244 >6GL0-A nrPDB Length = 331 Score = 32.4 bits (72), Expect = 0.43, Method: Composition-based stats. Identities = 17/112 (15%), Positives = 34/112 (30%), Gaps = 10/112 (8%) Query: 86 VITDLAATLVQSGVPVIRLAAGEPDFDTPKVVAEAGINAIREGFTRYTLNAGITELREAI 145 V T +A G +I EP + G R+ +Y + Sbjct: 124 VWTQIANRFKTYGDYLIFETLNEPRHKGTPEEWKGGTQEGRDAVNQYH---------QVS 174 Query: 146 CRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDE-VIIPAPYWVSY 196 ++ G + ++ + A + + GD+ VI+ + Y Sbjct: 175 VDAIRATGGNNAKRKIMVSTYAASTASNALNDYLVPNGDKNVIVSVHSYFPY 226 >3HMU-A nrPDB Length = 472 Score = 31.6 bits (70), Expect = 0.68, Method: Composition-based stats. Identities = 49/281 (17%), Positives = 84/281 (29%), Gaps = 50/281 (17%) Query: 144 AICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAV-------CSPGDEVIIPA-PYWVS 195 A+ +KL E + + + G ++ + V P VII + Sbjct: 103 ALAQKLAELAPGDL--NHVFFAGGGSEANDTNIRMVRTYWQNKGQPEKTVIISRKNAYHG 160 Query: 196 YTEQARLADA----------TPVVIPTKISNNFL----LDPKD--------LESKLTE-- 231 T + P V N + +DP++ LE + E Sbjct: 161 STVASSALGGMAGMHAQSGLIPDVHHINQPNWWAEGGDMDPEEFGLARARELEEAILELG 220 Query: 232 -KSRLLILCSPSNPTGSVY--PKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSF 288 + P G V P S EI RI K+ +L+++DE+ + Sbjct: 221 ENRVAAFIAEPVQGAGGVIVAPDSYWPEIQRICDKY-DILLIADEVICGFGRTGNWFGTQ 279 Query: 289 ASLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPK--HIVAACSKLQGQVSSGASSIAQKA 346 + T+ G S +A G G + + H++ G SG A Sbjct: 280 TMGIRPHIMTIA-KGLSSGYAPIG---GSIVCDEVAHVIGKDEFNHGYTYSGHPV----A 331 Query: 347 GVAALGLGKAGGET--VAEMVKAYRERRDFLVKSLGDIKGV 385 AL + E + + ++L D V Sbjct: 332 AAVALENLRILEEENILDHVRNVAAPYLKEKWEALTDHPLV 372 >4RIT-B nrPDB Length = 486 Score = 31.6 bits (70), Expect = 0.70, Method: Composition-based stats. Identities = 29/161 (18%), Positives = 54/161 (33%), Gaps = 30/161 (18%) Query: 163 LVSNGAKQSLLQAVLAV-------CSPGDEVIIPAP-------YWVSYTEQARLAD-ATP 207 ++++G + LQA+ PG + P S + A L T Sbjct: 149 VLTSGGSLANLQALAVARNVAFDSVEPGITGLAQRPVIFASEAAHTSLQKAAMLLGLGTA 208 Query: 208 VVIPTKISNNFLLDPKDLESKLTEKSRLLILCSPSNPT--------GSVYPKSLLEEIAR 259 VIP + + + +DP+DL +++ + +P + L EI Sbjct: 209 AVIPVRATADSRMDPEDLRARIDQARGA-----GQHPFCVVATAGTTTTGNIDPLAEIGA 263 Query: 260 IIAKHPRLLVLSDEIYEH-IIYAPATHTSFASLPDMYERTL 299 I +H L D Y ++++ A + T Sbjct: 264 IAREH-GLWFHVDAAYGGALVFSERHRWRLAGIEQADSITF 303 >4W8I-A nrPDB Length = 551 Score = 31.6 bits (70), Expect = 0.82, Method: Composition-based stats. Identities = 20/108 (18%), Positives = 49/108 (45%), Gaps = 11/108 (10%) Query: 163 LVSNGAKQSLLQAVLAVC----SPG---DEVIIPAPYWVSYTEQARLADATPVVIPTKIS 215 L+++G S+++A+ A + G E+++P ++ + A L A + +P Sbjct: 161 LLTHGGTTSIIEAMAAYVIRARAKGIDYPEIVVPETAHAAFKKAAELTGAILITVPVDKK 220 Query: 216 NNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAK 263 ++P + S +T + +++ +PS G + E+ ++ K Sbjct: 221 TG-AVNPNVMSSYITRNTAVMVGSAPSFMNGI---HDPISELGQLAKK 264 >1QZ9-A nrPDB Length = 416 Score = 31.2 bits (69), Expect = 0.88, Method: Composition-based stats. Identities = 23/148 (15%), Positives = 58/148 (39%), Gaps = 14/148 (9%) Query: 135 NAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQA------VLAVCSPGDEVII 188 +AG +L E + +L G +++V++ +L + V A SP VI+ Sbjct: 66 SAGWRDLSERLGNRLATLIGA--RDGEVVVTDTTSINLFKVLSAALRVQATRSPERRVIV 123 Query: 189 PAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSV 248 ++ +A+ ++ + + P++L + + + +++L + TG + Sbjct: 124 TETS--NFPTDLYIAEGLADMLQQGYTLRLVDSPEELPQAIDQDTAVVMLTHVNYKTGYM 181 Query: 249 YPKSLLEEIARIIAKHPRLLVLSDEIYE 276 + L ++ L + D + Sbjct: 182 HDMQALTALSHEC----GALAIWDLAHS 205 >3TQP-A nrPDB Length = 428 Score = 31.2 bits (69), Expect = 0.91, Method: Composition-based stats. Identities = 18/84 (21%), Positives = 35/84 (41%), Gaps = 11/84 (13%) Query: 110 DFDTPKVVAEAGINAIREGFTRYTLNAGITELRE-AICRK----LKEENGLSYAPDQILV 164 DF+ ++ +E I+ + E +Y + + L E + EN + D I V Sbjct: 257 DFENNQLTSEEMIDRLTEWTKKYPVISIEDGLSENDWAGWKLLTERLENKVQLVGDDIFV 316 Query: 165 SN------GAKQSLLQAVLAVCSP 182 +N G K+++ A+L + Sbjct: 317 TNPDILEKGIKKNIANAILVKLNQ 340 >1V6T-A nrPDB Length = 255 Score = 31.2 bits (69), Expect = 1.0, Method: Composition-based stats. Identities = 18/164 (10%), Positives = 49/164 (29%), Gaps = 25/164 (15%) Query: 275 YEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQ 334 Y ++ + +++ L + S + R+ +A + A + Sbjct: 115 YNAMVKEEDLARAVIEGILDFDKDLILVTLSNS------RVADIAEEMGLKVAHEVFADR 168 Query: 335 VSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLGDIKGVKISEPQGAF 394 + ++ + A+ K E + ++ + D G++ + Sbjct: 169 AYNPDGTLVPRGRPGAVIEDK-------------EEIAERVISMVKD-GGIRAINGE--- 211 Query: 395 YLFIDFSAYYGSEAEGFGLINDSSSLALYFLDKFQVAMVPGDAF 438 ++D + +S L++ V +VP F Sbjct: 212 --WVDLKVDTICVHGDNPKAVEITSYIRKVLEEEGVKIVPMKEF 253 >1ORD-A nrPDB Length = 730 Score = 31.2 bits (69), Expect = 1.1, Method: Composition-based stats. Identities = 46/301 (15%), Positives = 91/301 (30%), Gaps = 55/301 (18%) Query: 163 LVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVS-YTEQARLADATPVVIPTKISNNFLL- 220 V G+ + A+ S GD V+ S Y +A PV + T + + Sbjct: 193 FVLGGSSNANNTVTSALVSNGDLVLFDRNNHKSVYNSALAMAGGRPVYLQTNRNPYGFIG 252 Query: 221 -------DPKDLESKLT----EKSRL-----LILCSPSNPTGSVYP-KSLLEEIARIIAK 263 D K + E+++ L + G++Y +++ I + Sbjct: 253 GIYDSDFDEKKIRELAAKVDPERAKWKRPFRLAVIQLGTYDGTIYNAHEVVKRIGHLCD- 311 Query: 264 HPRLLVLSDEI---YEHIIY--APATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYL 318 + D YE I ++ L + V K G+ Sbjct: 312 ----YIEFDSAWVGYEQFIPMMRNSSPLLIDDLGPEDPGIIVVQSVHKQQ--AGF----- 360 Query: 319 AGPKHIVAACSKLQGQVSSG------------ASSIAQKAGVAALGLGKAGGETVAEMVK 366 + I S ++GQ+ S+ AAL + A E A Sbjct: 361 SQTSQIHKKDSHIKGQLRYCDHKHFNNSFNLFMSTSPFYPMYAALDVNAAMQEGEAGRKL 420 Query: 367 AYRERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSSLALYFLD 426 D L+ ++ K + + G+ + G + E + ++++ + + Sbjct: 421 W----HDLLITTIEARKKLIKA---GSMFRPFVPPVVNGKKWEDGDTEDMANNIDYWRFE 473 Query: 427 K 427 K Sbjct: 474 K 474 >4XGC-B nrPDB Length = 354 Score = 31.2 bits (69), Expect = 1.1, Method: Composition-based stats. Identities = 34/184 (18%), Positives = 70/184 (38%), Gaps = 8/184 (4%) Query: 111 FDTPKVVAEAGINAIREGFTRYTLNAGITELREAICRKLKEENGLSYAPDQILV-SNGAK 169 P++ A+ + + E T I + E + + IL+ G+K Sbjct: 38 LKNPRLAADRVFSLLSEIKTSAEHEGSINAIMEEYRSYFPKWMCILNEGFNILLYGLGSK 97 Query: 170 QSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKIS---NNFLLDPKDLE 226 LLQ+ V++ ++ S T + L T ++ IS + +D + E Sbjct: 98 HQLLQSFHREVLHKQTVLVVNGFFPSLTIKDMLDSITSDILDAGISPANPHEAVDMIEEE 157 Query: 227 SKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLS--DEIYEHIIYAPAT 284 L ++ L ++ N G++ + I +A+ P + +L+ D I +++ Sbjct: 158 FALIPETHLFLIV--HNLDGAMLRNVKAQAILSRLARIPNIHLLASIDHINTPLLWDQGK 215 Query: 285 HTSF 288 SF Sbjct: 216 LCSF 219 >1IUG-A nrPDB Length = 352 Score = 30.5 bits (67), Expect = 1.5, Method: Composition-based stats. Identities = 46/252 (18%), Positives = 86/252 (34%), Gaps = 30/252 (11%) Query: 161 QILVSNGA-KQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNNFL 219 ++L+ G+ ++ V + +PG+ V++P S +A VV Sbjct: 52 EVLILTGSGTLAMEALVKNLFAPGERVLVPVYGKFSERFYEIALEAGLVVERLDYPYGDT 111 Query: 220 LDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHII 279 P+D+ E L+L TG++ L K+P LV +D + ++ Sbjct: 112 PRPEDVA---KEGYAGLLLVHSETSTGALADLPALAR--AFKEKNPEGLVGADMVTSLLV 166 Query: 280 YAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGA 339 A + +G K LG++A + + Sbjct: 167 GEVAL--------EAMGVDAAASGSQKGLMCPPG-LGFVALSPRALERLKPRGYYLDLAR 217 Query: 340 SSIAQKAGVAAL----GLGKAGGETVAEMVKAYRER------RDFLVKSLGDIKGVKISE 389 AQK G +A L A + E++ E ++ L+ +G+ G++ Sbjct: 218 ELKAQKEGESAWTPAINLVLAVAAVLEEVLPRLEEHLALKAWQNALLYGVGEEGGLRPVP 277 Query: 390 PQ-----GAFYL 396 + AFYL Sbjct: 278 KRFSPAVAAFYL 289 >2XN1-A nrPDB Length = 732 Score = 30.1 bits (66), Expect = 2.0, Method: Composition-based stats. Identities = 15/51 (29%), Positives = 24/51 (47%), Gaps = 2/51 (3%) Query: 105 AAGEPDFDTPKVVAE--AGINAIREGFTRYTLNAGITELREAICRKLKEEN 153 +AGE DF TP + G NA+ + Y + G +L+ KE++ Sbjct: 82 SAGEMDFHTPATIVRNPDGSNALFLAYKSYKIEDGKPDLKGLPHSWTKEDD 132 >3S81-A nrPDB Length = 268 Score = 30.1 bits (66), Expect = 2.5, Method: Composition-based stats. Identities = 7/33 (21%), Positives = 14/33 (42%) Query: 196 YTEQARLADATPVVIPTKISNNFLLDPKDLESK 228 Y A A +VIP ++ + D +++ Sbjct: 91 YLHMLEDAGAECIVIPCNTAHYWFDDLQNVAKA 123 >4XEM-A nrPDB Length = 475 Score = 29.3 bits (64), Expect = 3.4, Method: Composition-based stats. Identities = 15/84 (17%), Positives = 32/84 (38%), Gaps = 2/84 (2%) Query: 234 RLLILCS--PSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASL 291 + + L + PS+P + + ++ R KH L + ++Y H + SF Sbjct: 70 KPIFLNTIDPSHPMAKLSRAANTQKCIRAGGKHNDLDDVGKDVYHHTFFEMLGSWSFGDY 129 Query: 292 PDMYERTLTVNGFSKAFAMTGWRL 315 + + ++ F + RL Sbjct: 130 FKELACKMALELLTQEFGIPIERL 153 >3DOD-A nrPDB Length = 448 Score = 29.3 bits (64), Expect = 3.7, Method: Composition-based stats. Identities = 34/236 (14%), Positives = 72/236 (30%), Gaps = 28/236 (11%) Query: 248 VYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLT-VNGFSK 306 V P+ L + + + L+++ DE+ +E + K Sbjct: 228 VMPEGYLAGVRELCTTYDVLMIV-DEVATGFGRTGKMFAC------EHENVQPDLMAAGK 280 Query: 307 AFAMTG--WRLGYLAGPKHIVAAC----SKLQGQVSSGASSIAQKAGVAAL-GLGKAGGE 359 +TG + + I A L+ + + Q AL L E Sbjct: 281 --GITGGYLPIAVTFATEDIYKAFYDDYENLKTFFHGHSYTGNQLGCAVALENLALFESE 338 Query: 360 TVAEMVKAYRERRDFLVKSLGDIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDSSS 419 + E V ++ FL++ L + V G F + ++ Sbjct: 339 NIVEQVAEKSKKLHFLLQDLHALPHVGDIRQLG-FMCGAELVRSKETKEPYPADRRIGYK 397 Query: 420 LALYFLDKFQVAMVPGD---AFGDDSCIRISYATSLDVLQAAVEKIRKALEPLRAT 472 ++L + + P AF A++ + L V +++A+ + + Sbjct: 398 VSLKM-RELGMLTRPLGDVIAFLPP------LASTAEELSEMVAIMKQAIHEVTSL 446 >3ZRR-A nrPDB Length = 384 Score = 29.3 bits (64), Expect = 4.2, Method: Composition-based stats. Identities = 30/164 (18%), Positives = 66/164 (40%), Gaps = 16/164 (9%) Query: 114 PKVVAEAGINAIREGFTRYTLNAGITELREAICRKLKEENGLSYAPDQ----ILVSNGAK 169 P + E + A E +T E EA+ LK + A I+ G Sbjct: 10 PTTIKEDVLVAGLENNVGFTS----KEFVEALAYSLKGLRYVMGASKNYQPLIIPGGGTS 65 Query: 170 QSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADATPVVIP-TKISNNFLLDPKDLESK 228 +++V ++ P D++++ + V ++ PV + + S + P ++E + Sbjct: 66 A--MESVTSLLKPNDKILVVSNG-VFGDRWEQIFKRYPVNVKVLRPSPGDYVKPGEVEEE 122 Query: 229 L-TEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLS 271 + + +L+ L TG + ++++ I K+ L+V+ Sbjct: 123 VRKSEYKLVALTHVETSTGV---REPVKDVINKIRKYVELIVVD 163 >3O55-A nrPDB Length = 125 Score = 29.3 bits (64), Expect = 4.3, Method: Composition-based stats. Identities = 14/60 (23%), Positives = 20/60 (33%), Gaps = 1/60 (1%) Query: 88 TDLAATLVQSGVPVIRLAAGEPDFDTPKVVAEAGINAIREGFTRYTLNAGITELREAICR 147 D S + LAA PD TP+ + I Y +LR+ + R Sbjct: 17 PDREELGRHSWAVLHTLAAYYPDLPTPEQ-QQDMAQFIHLFSKFYPCEECAEDLRKRLAR 75 >3QTP-A nrPDB Length = 441 Score = 28.9 bits (63), Expect = 5.0, Method: Composition-based stats. Identities = 17/112 (15%), Positives = 42/112 (37%), Gaps = 8/112 (7%) Query: 166 NGAKQSLLQAVLAVCSPGD----EVIIPAPYWVSYTEQARLADATPVVIPTKISNNFLLD 221 +GA+++L V A+ G E+ + Y E+ + D + K + + D Sbjct: 221 SGAREALDLLVEAIAKAGYTGKIEIAMDCAASEFYNEETKKYDLGKKIPADKKDPSLVKD 280 Query: 222 PKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDE 273 L ++ + + + S +P + + + +H ++ D+ Sbjct: 281 VDGLIAEYVDYGKHYPIASIEDP----FAEDDWAAWNKFTVEHGNFQIVGDD 328 >4UT1-A nrPDB Length = 673 Score = 28.5 bits (62), Expect = 5.7, Method: Composition-based stats. Identities = 11/51 (21%), Positives = 23/51 (45%) Query: 348 VAALGLGKAGGETVAEMVKAYRERRDFLVKSLGDIKGVKISEPQGAFYLFI 398 +A L A + + ++RD V L + GV++ + G + +F+ Sbjct: 183 IAQLNEQIASASSQGQPPNQLLDQRDLAVSKLSQLAGVQVVQSNGNYSVFL 233 >2HQM-A nrPDB Length = 479 Score = 28.5 bits (62), Expect = 7.1, Method: Composition-based stats. Identities = 22/155 (14%), Positives = 46/155 (29%), Gaps = 28/155 (18%) Query: 305 SKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEM 364 +KA T +G + K+ S A+ ++ E + Sbjct: 42 AKALGGTCVNVGCVP---------KKVMWYASDLATRVSHANEYGLYQNLPLDKEHLTFN 92 Query: 365 VKAYRERRDFLVKSLG-------DIKGVKISEPQGAFYLFIDFSAYYGSEAEGFGLINDS 417 ++++RD V L + + V + + + F+ E + + Sbjct: 93 WPEFKQKRDAYVHRLNGIYQKNLEKEKVDVV------FGWARFNKDGNVEVQKRDNTTEV 146 Query: 418 SSLALYFLDKFQVAM----VPGDAFG--DDSCIRI 446 S + A+ +PG G D R+ Sbjct: 147 YSANHILVATGGKAIFPENIPGFELGTDSDGFFRL 181 >2R9G-A nrPDB Length = 204 Score = 28.2 bits (61), Expect = 8.2, Method: Composition-based stats. Identities = 15/90 (16%), Positives = 31/90 (34%), Gaps = 5/90 (5%) Query: 65 SSSVDMSLSPRVQSLKPSKTMVITDLAATLVQSGVPVIRLAAG--EP-DFDTPKVVAEAG 121 S+S M+L + ++ K + D G + G P FD V + Sbjct: 104 SNSAYMALDAALADIREGKAGDVPDHLRDSHYKGAKSLNRGVGYQYPHHFDQAWVNQQYL 163 Query: 122 INAIREGFTRYTLNAGITELREAICRKLKE 151 + ++ + G E +A+ ++ Sbjct: 164 PDKLKNAQYYQPKDTGKYE--QALGQQYYR 191 >6GIO-D nrPDB Length = 439 Score = 28.2 bits (61), Expect = 8.6, Method: Composition-based stats. Identities = 10/28 (35%), Positives = 15/28 (53%), Gaps = 1/28 (3%) Query: 247 SVYPKSLLEEIARIIAKHPRLLVLSDEI 274 V P + LE + KH +LV+ DE+ Sbjct: 214 VVPPPAFLEALQDRCRKH-GILVVVDEV 240 >1OBH-A nrPDB Length = 878 Score = 28.2 bits (61), Expect = 8.9, Method: Composition-based stats. Identities = 10/78 (12%), Positives = 27/78 (34%), Gaps = 5/78 (6%) Query: 323 HIVAACSKLQGQVSSGA---SSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSL 379 ++A ++QG + A AAL G + ++ +E + + Sbjct: 60 DVLARFRRMQGYEVLHPMGWDAFGLPAENAALKFGVHPKDWTYANIRQAKESLRLM--GI 117 Query: 380 GDIKGVKISEPQGAFYLF 397 +++ + +Y + Sbjct: 118 LYDWDREVTTCEPEYYRW 135 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.309 0.129 0.330 Lambda K H 0.267 0.0399 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 15,739,388 Number of Sequences: 36641 Number of extensions: 570452 Number of successful extensions: 3218 Number of sequences better than 10.0: 218 Number of HSP's better than 10.0 without gapping: 205 Number of HSP's successfully gapped in prelim test: 129 Number of HSP's that attempted gapping in prelim test: 2309 Number of HSP's gapped (non-prelim): 351 length of query: 475 length of database: 10,336,785 effective HSP length: 101 effective length of query: 374 effective length of database: 6,636,044 effective search space: 2481880456 effective search space used: 2481880456 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.2 bits) S2: 61 (28.1 bits)