BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q9NQH7 (507 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 5X49-A nrPDB 949 0.0 5WZE-A nrPDB 281 6e-76 6A9U-A nrPDB 279 2e-75 2BWY-A nrPDB 234 6e-62 4PV4-A nrPDB 230 1e-60 3IG4-A nrPDB 168 6e-42 5MC5-A nrPDB 164 7e-41 3Q6D-A nrPDB 117 1e-26 1PV9-A nrPDB 114 8e-26 1WY2-A nrPDB 114 8e-26 4ZNG-C nrPDB 114 1e-25 5CNX-A nrPDB 108 4e-24 2ZSG-A nrPDB 107 1e-23 4RGZ-A nrPDB 87 2e-17 4QR8-A nrPDB 82 5e-16 3RVA-A nrPDB 80 3e-15 4ZWP-A nrPDB 70 2e-12 3L7G-A nrPDB 68 1e-11 4FO7-A nrPDB 57 2e-08 6MRF-A nrPDB 52 7e-07 4A6V-A nrPDB 52 7e-07 3TB5-A nrPDB 49 4e-06 4KM3-A nrPDB 47 1e-05 3CTZ-A nrPDB 47 2e-05 1O0X-A nrPDB 45 5e-05 1QXW-A nrPDB 44 2e-04 4S2R-P nrPDB 43 3e-04 5CE6-A nrPDB 42 5e-04 5JR6-A nrPDB 39 0.004 2B3K-A nrPDB 36 0.038 3ROR-A nrPDB 35 0.052 1CHM-A nrPDB 35 0.086 4IU6-A nrPDB 35 0.092 2CDU-A nrPDB 32 0.64 6CR2-A nrPDB 32 0.76 3ZH9-B nrPDB 30 3.5 5D08-A nrPDB 29 3.7 6F8L-G nrPDB 29 5.0 2P0M-A nrPDB 28 6.5 5A8D-A nrPDB 28 8.8 6MTD-E nrPDB 28 9.2 >5X49-A nrPDB Length = 456 Score = 949 bits (2453), Expect = 0.0, Method: Compositional matrix adjust. Identities = 454/455 (99%), Positives = 455/455 (100%) Query: 53 THPHLLRPGEVTPGLSQVEYALRRHKLMSLIQKEAQGQSGTDQTVVVLSNPTYYMSNDIP 112 +HPHLLRPGEVTPGLSQVEYALRRHKLMSLIQKEAQGQSGTDQTVVVLSNPTYYMSNDIP Sbjct: 2 SHPHLLRPGEVTPGLSQVEYALRRHKLMSLIQKEAQGQSGTDQTVVVLSNPTYYMSNDIP 61 Query: 113 YTFHQDNNFLYLCGFQEPDSILVLQSLPGKQLPSHKAILFVPRRDPSRELWDGPRSGTDG 172 YTFHQDNNFLYLCGFQEPDSILVLQSLPGKQLPSHKAILFVPRRDPSRELWDGPRSGTDG Sbjct: 62 YTFHQDNNFLYLCGFQEPDSILVLQSLPGKQLPSHKAILFVPRRDPSRELWDGPRSGTDG 121 Query: 173 AIALTGVDEAYTLEEFQHLLPKMKAETNMVWYDWMRPSHAQLHSDYMQPLTEAKAKSKNK 232 AIALTGVDEAYTLEEFQHLLPKMKAETNMVWYDWMRPSHAQLHSDYMQPLTEAKAKSKNK Sbjct: 122 AIALTGVDEAYTLEEFQHLLPKMKAETNMVWYDWMRPSHAQLHSDYMQPLTEAKAKSKNK 181 Query: 233 VRGVQQLIQRLRLIKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKFEFECRA 292 VRGVQQLIQRLRLIKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKFEFECRA Sbjct: 182 VRGVQQLIQRLRLIKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKFEFECRA 241 Query: 293 RGADILAYPPVVAGGNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGR 352 RGADILAYPPVVAGGNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGR Sbjct: 242 RGADILAYPPVVAGGNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGR 301 Query: 353 FTAPQAELYEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMKNIKENNAFK 412 FTAPQAELYEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMKNIKENNAFK Sbjct: 302 FTAPQAELYEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMKNIKENNAFK 361 Query: 413 AARKYCPHHVGHYLGMDVHDTPDMPRSLPLQPGMVITIEPGIYIPEDDKDAPEKFRGLGV 472 AARKYCPHHVGHYLGMDVHDTPDMPRSLPLQPGMVITIEPGIYIPEDDKDAPEKFRGLGV Sbjct: 362 AARKYCPHHVGHYLGMDVHDTPDMPRSLPLQPGMVITIEPGIYIPEDDKDAPEKFRGLGV 421 Query: 473 RIEDDVVVTQDSPLILSADCPKEMNDIEQICSQAS 507 RIEDDVVVTQDSPLILSADCPKEMNDIEQICSQAS Sbjct: 422 RIEDDVVVTQDSPLILSADCPKEMNDIEQICSQAS 456 >5WZE-A nrPDB Length = 452 Score = 281 bits (718), Expect = 6e-76, Method: Compositional matrix adjust. Identities = 159/444 (35%), Positives = 250/444 (56%), Gaps = 20/444 (4%) Query: 71 EYALRRHKLMSLIQKEAQGQSGTDQTVVVLSNPTYYMSNDIPYTFHQDNNFLYLCGFQEP 130 EYA RR LM+ Q + ++ + P Y + D+ + + QD++F YL GF EP Sbjct: 8 EYARRRKALMA--------QMEPNSIAILPAAPMYIRNRDVEHVYRQDSDFQYLTGFPEP 59 Query: 131 DSILVLQSLPGKQLPSHKAILFVPRRDPSRELWDGPRSGTDGAIALTGVDEAYTLEEFQH 190 ++++ L +PG+ + +LF RDP RELWDG R+G DGAI G D+A+ + + Sbjct: 60 EAVMAL--IPGRAHGEY--VLFCRERDPERELWDGLRAGQDGAIGQYGADDAFPIGDIDD 115 Query: 191 LLPKMKAETNMVWYDW-MRPSHAQLHSDYMQPL-TEAK--AKSKNKVRGVQQLIQRLRLI 246 +LP + + V+Y P + D++ + ++A+ A+ N+ + L+ RL Sbjct: 116 ILPGLIEGRDRVYYALGANPDFDRRLMDWINVIRSKARQGAQPPNEFVALDHLLHDQRLY 175 Query: 247 KSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKFEFECRARGADILAYPPVVAG 306 KS E++ M+ A +++++A I M + + E L A+ E+E R GA + AY +VA Sbjct: 176 KSANEVKVMRYAAEVSARAHIRAMEVCRPGLFEYHLEAELEYEFRKGGAKMPAYGSIVAA 235 Query: 307 GNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGRFTAPQAELYEAVLE 366 G + LHY +N+ IKDG+++L+D GCE CY SDITRT+P NGRF+ Q +YE VLE Sbjct: 236 GRNACILHYRENDAAIKDGDLILIDAGCEIDCYASDITRTFPANGRFSPEQKAIYELVLE 295 Query: 367 IQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMK-NIKENNAFKAARKYCPHHVGHY 425 PG + + +I L LG+++ ++ E A +A + + H GH+ Sbjct: 296 ANMAAFDYIAPGRHWNEAHEATVRVITAGLVRLGLLEGDVDELIAHEAYKAFYMHRAGHW 355 Query: 426 LGMDVHDTPDM---PRSLPLQPGMVITIEPGIYIPEDDKDAPEKFRGLGVRIEDDVVVTQ 482 LGMDVHD + L+PGM +T+EPGIYI D+ +K+RG+GVRIEDDVVVT+ Sbjct: 356 LGMDVHDVGEYRVGGEWRVLEPGMAMTVEPGIYIAPDNTTVAKKWRGIGVRIEDDVVVTR 415 Query: 483 DSPLILSADCPKEMNDIEQICSQA 506 + +L+ PK + +IE + + A Sbjct: 416 NGCEVLTNGVPKTVAEIEALMAAA 439 >6A9U-A nrPDB Length = 455 Score = 279 bits (713), Expect = 2e-75, Method: Compositional matrix adjust. Identities = 161/456 (35%), Positives = 258/456 (56%), Gaps = 34/456 (7%) Query: 61 GEVTPGLSQVEYALRRHKLMSLIQKEAQGQSGTDQTVVVLSNPTYYMSNDIPYTFHQDNN 120 GE+TPG+S +EY RR +L + ++ V++ N + S + Y F Q+N+ Sbjct: 3 GELTPGISALEYYERRIRLAETLPPKS--------CVILAGNDIQFASGAVFYPFQQEND 54 Query: 121 FLYLCGFQEPDSILVLQSLPGKQLPSHKAILFVPRRDPSRELWDGPRSGTDGAIALTGVD 180 YL G+ EP+S+++L+ P L + VP +D E W+G RSG G + D Sbjct: 55 LFYLSGWNEPNSVMILEK-PTDSLSDTIFHMLVPPKDAFAEKWEGFRSGVYGVQEIFNAD 113 Query: 181 EAYTLEEFQHLLPKMKAETNMVWYDWMRPSH-AQLHSDYMQPLTEAKAKSK-------NK 232 E+ ++ + LPK+ +++D + S+ + + +++ L + S NK Sbjct: 114 ESASINDLSKYLPKIINRNEFIYFDMLSTSNPSSSNFKHIKSLLDGSGNSNRSLNSIANK 173 Query: 233 -VRGVQQLIQRLRLIKSPAEIERMQIAGKLTSQAFIETMFTSKAPVE---EAFLYAKFEF 288 ++ + + I R IKSP E+ M+ AG+++ ++F + F + E ++FL+ KF Sbjct: 174 TIKPISKRIAEFRKIKSPQELRIMRRAGQISGRSFNQA-FAKRFRNERTLDSFLHYKF-- 230 Query: 289 ECRARGADILAYPPVVAGGNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWP 348 + G D AY PVVA G+ S +HY +N+ ++ D EMVL+D Y +DI+RTWP Sbjct: 231 --ISGGCDKDAYIPVVATGSNSLCIHYTRNDDVMFDDEMVLVDAAGSLGGYCADISRTWP 288 Query: 349 VNGRFTAPQAELYEAVLEIQRDCLALCFPGT--SLENIYSMMLTLIGQKLKDLGIMKNIK 406 +G+FT Q +LYEAVL +QRDC+ LC SL +I+ +TL+ Q+LK+LGI K Sbjct: 289 NSGKFTDAQRDLYEAVLNVQRDCIKLCKASNNYSLHDIHEKSITLMKQELKNLGIDKVSG 348 Query: 407 ENNAFKAARKYCPHHVGHYLGMDVHDTPDMPRSLPLQPGMVITIEPGIYIPEDDKDAPEK 466 N K PH++GH LG+DVHD P + R PL+ G VITIEPG+YIP +++ P Sbjct: 349 WN-----VEKLYPHYIGHNLGLDVHDVPKVSRYEPLKVGQVITIEPGLYIP-NEESFPSY 402 Query: 467 FRGLGVRIEDDVVVTQDSPLILSADCPKEMNDIEQI 502 FR +G+RIEDD+ + +D+ L+ + KE++D+E + Sbjct: 403 FRNVGIRIEDDIAIGEDTYTNLTVEAVKEIDDLENV 438 >2BWY-A nrPDB Length = 440 Score = 234 bits (597), Expect = 6e-62, Method: Compositional matrix adjust. Identities = 152/456 (33%), Positives = 234/456 (51%), Gaps = 37/456 (8%) Query: 67 LSQVEYALRRHKLMSLIQKEAQGQSGTDQTVVVLSNPTYYMSNDIPYTFHQDNNFLYLCG 126 +S+ E+ RR L+ Q Q G+ ++ + P S D Y + Q+++F Y G Sbjct: 3 ISRQEFQRRRQALVE------QMQPGS--AALIFAAPEVTRSADSEYPYRQNSDFWYFTG 54 Query: 127 FQEPDSILVLQSLPGKQLPSHKAILFVPRRDPSRELWDGPRSGTDGAIALTGVDEAYTLE 186 F EP+++LVL + +H ++LF RD + E+W G R G D A GVD A Sbjct: 55 FNEPEAVLVL--IKSDDTHNH-SVLFNRVRDLTAEIWFGRRLGQDAAPEKLGVDRALAFS 111 Query: 187 EFQHLLPKMKAETNMVWYDWMRPSHAQLHSDYMQPLTEAKAKSKNKVRGVQQ-------- 238 E L ++ ++V+ HAQ Y + + + K G +Q Sbjct: 112 EINQQLYQLLNGLDVVY-------HAQGEYAYADVIVNSALEKLRK--GSRQNLTAPATM 162 Query: 239 -----LIQRLRLIKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKFEFECRAR 293 ++ +RL KSP EI ++ AG++T+ A M + + E L + E Sbjct: 163 IDWRPVVHEMRLFKSPEEIAVLRRAGEITAMAHTRAMEKCRPGMFEYHLEGEIHHEFNRH 222 Query: 294 GADILAYPPVVAGGNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGRF 353 GA +Y +V G LHY +N ++DG++VL+D GCE Y DITRT+PVNG+F Sbjct: 223 GARYPSYNTIVGSGENGCILHYTENECEMRDGDLVLIDAGCEYKGYAGDITRTFPVNGKF 282 Query: 354 TAPQAELYEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMK-NIKENNAFK 412 T Q E+Y+ VLE L L PGTS+ + ++ ++ L LGI+K ++ E A Sbjct: 283 TQAQREIYDIVLESLETSLRLYRPGTSILEVTGEVVRIMVSGLVKLGILKGDVDELIAQN 342 Query: 413 AARKYCPHHVGHYLGMDVHDTP--DMPRSLPLQPGMVITIEPGIYIPEDDKDAPEKFRGL 470 A R + H + H+LG+DVHD RS L+PGMV+T+ PG+YI D + PE++RG+ Sbjct: 343 AHRPFFMHGLSHWLGLDVHDVGVYGQDRSRILEPGMVLTVAPGLYIA-PDAEVPEQYRGI 401 Query: 471 GVRIEDDVVVTQDSPLILSADCPKEMNDIEQICSQA 506 G+RIEDD+V+T+ L+A K+ +IE + A Sbjct: 402 GIRIEDDIVITETGNENLTASVVKKPEEIEALMVAA 437 >4PV4-A nrPDB Length = 445 Score = 230 bits (587), Expect = 1e-60, Method: Compositional matrix adjust. Identities = 147/448 (32%), Positives = 237/448 (52%), Gaps = 24/448 (5%) Query: 67 LSQVEYALRRHKLMSLIQKEAQGQSGTDQTVVVLSNPTYYMSNDIPYTFHQDNNFLYLCG 126 ++Q EY RR L++ K A G + ++ + P S D Y + Q+++F YL G Sbjct: 1 MTQQEYQNRRQALLA---KMAPGSAA-----IIFAAPEATRSADSEYPYRQNSDFSYLTG 52 Query: 127 FQEPDSILVLQSLPGKQLPSHKAILFVPRRDPSRELWDGPRSGTDGAIALTGVDEAYTLE 186 F EP+++L+L + + +H ++LF RD + E+W G R G + A VD A + Sbjct: 53 FNEPEAVLIL--VKSDETHNH-SVLFNRIRDLTAEIWFGRRLGQEAAPTKLAVDRALPFD 109 Query: 187 EFQHLLPKMKAETNMVWYDWMRPSHAQLHSDYMQPLTEAKAKSKNKVRGVQQL------I 240 E L + +++++ + +A + L + + + +R L + Sbjct: 110 EINEQLYLLLNRLDVIYH--AQGQYAYADNIVFAALEKLRHGFRKNLRAPATLTDWRPWL 167 Query: 241 QRLRLIKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKFEFECRARGADILAY 300 +RL KS EI ++ AG++++ A M + + E L + E GA AY Sbjct: 168 HEMRLFKSAEEIAVLRRAGEISALAHTRAMEKCRPGMFEYQLEGEILHEFTRHGARYPAY 227 Query: 301 PPVVAGGNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGRFTAPQAEL 360 +V GG LHY +N ++DG++VL+D GCE Y DITRT+PVNG+FT Q + Sbjct: 228 NTIVGGGENGCILHYTENECELRDGDLVLIDAGCEYRGYAGDITRTFPVNGKFTPAQRAV 287 Query: 361 YEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMK-NIKENNAFKAARKYCP 419 Y+ VL L L PGTS+ + ++ ++ L +LGI+K +I++ A +A R + Sbjct: 288 YDIVLAAINKSLTLFRPGTSIREVTEEVVRIMVVGLVELGILKGDIEQLIAEQAHRPFFM 347 Query: 420 HHVGHYLGMDVHDTPDM---PRSLPLQPGMVITIEPGIYIPEDDKDAPEKFRGLGVRIED 476 H + H+LGMDVHD D R L+PGMV+T+EPG+YI D D P ++RG+G+RIED Sbjct: 348 HGLSHWLGMDVHDVGDYGSSDRGRILEPGMVLTVEPGLYIAP-DADVPPQYRGIGIRIED 406 Query: 477 DVVVTQDSPLILSADCPKEMNDIEQICS 504 D+V+T L+A K+ +DIE + + Sbjct: 407 DIVITATGNENLTASVVKDPDDIEALMA 434 >3IG4-A nrPDB Length = 427 Score = 168 bits (425), Expect = 6e-42, Method: Compositional matrix adjust. Identities = 117/408 (28%), Positives = 203/408 (49%), Gaps = 36/408 (8%) Query: 94 DQTVVVL-SNPTYYMSNDIPYTFHQDNNFLYLCGFQEPDSILVLQSLPGKQLPSHKAILF 152 D+++ +L + +MS D Y F + NF Y+ G EP+ I +L+ S + LF Sbjct: 19 DESITILFAGQAPHMSADAHYKFVPNRNFYYVTGIDEPNVIFMLKKFGN----SVEETLF 74 Query: 153 VPRRDPSRELWDGPRSGTDGAIALTGVDEAYTLEEFQHLLPKMKAETNMVWYDWMRPSHA 212 + + DP E W G + A ++G+ + L+ F+ K +N+ + + ++ + Sbjct: 75 IEKSDPVMEKWVGKTVSNEEAEKISGIKKVIYLDSFE------KTMSNIFFTENVKHLYL 128 Query: 213 QLH-SDYMQPLTEAKAKSKN--------KVRGVQQLIQRLRLIKSPAEIERMQIAGKLTS 263 L ++ T+ A +K+ + V I LR+ K+ EIE ++ A +T Sbjct: 129 DLECREWKGTETKTLAFAKHVREQYPHVTIGNVYPNICELRVFKTDEEIEIIKEAIAVTK 188 Query: 264 QAFIETMFTSKAPVEEAFLYAKFEFECRARGADILAYPPVVAGGNRSNTLHYVKNNQLIK 323 + +KA + E L A+F+F ++ G A+ ++A G + LHY N+ I+ Sbjct: 189 DGIYNVLKHAKADMMEYELEAQFDFTLKSSGIKHHAFNTILASGKNATVLHYEDNDAQIQ 248 Query: 324 DGEMVLLDGGCESSCYVSDITRTWPVNGRFTAPQAELYEAVLEIQRDCLALCFPGTSLEN 383 +G++VLLD G + Y +DI+ T+P NG F++ Q ++Y VL ++ + PG Sbjct: 249 NGDLVLLDLGAQKDYYNADISYTFPANGTFSSRQKQIYNIVLNALKETTEIIKPGLKFAA 308 Query: 384 IYSMMLTLIGQKLKDLGIMKNIKENNAFKAARKYCPHHVGHYLGMDVHDTPDMPRSLPLQ 443 + ++ + K +G+++ +E KY H V H+LG+D HD + L+ Sbjct: 309 LNEHAKKVLAEGCKAVGLIQEDEE------LSKYYYHGVSHFLGLDTHDVGTYKDRV-LE 361 Query: 444 PGMVITIEPGIYIPEDDKDAPEKFRGLGVRIEDDVVVTQDSPLILSAD 491 GMVITIEPG+YI E+ +G+RIEDD++VT+D LS D Sbjct: 362 EGMVITIEPGLYIEEE---------SIGIRIEDDILVTKDGHENLSKD 400 >5MC5-A nrPDB Length = 478 Score = 164 bits (416), Expect = 7e-41, Method: Compositional matrix adjust. Identities = 135/468 (28%), Positives = 212/468 (45%), Gaps = 54/468 (11%) Query: 72 YALRRHKLMSLIQKEAQGQSGTDQTVVVL--SNPTYYMSNDIPYTFHQDNNFLYLCGFQE 129 +AL R +L ++K Q+G+ +VVL T D F Q++ F + G E Sbjct: 18 FALNRQRLCERLRKNPAVQAGS---IVVLQGGEETQRYCTDTGVLFRQESFFHWAFGVTE 74 Query: 130 PDSILVLQSLPGKQLPSHKAILFVPRRDPSRELWDGPRSGTDGAIALTGVDEAYTLEEFQ 189 P V+ GK + LFVPR S W G + VD+ ++E Sbjct: 75 PGCYGVIDVDTGK------STLFVPRLPASHATWMGKIHSKEHFKEKYAVDDVQYVDEIA 128 Query: 190 HLLPKMKAETNMVWYDWMRPSHAQLHSDYMQPLTEAKAKSKNKVRGVQQLIQRLRLIKSP 249 +L K + +R + S + + +K + + I R+ K+ Sbjct: 129 SVLTSQKPSVLLT----LRGVNTDSGSVCREASFDGISKFEVNNTILHPEIVECRVFKTD 184 Query: 250 AEIERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKFEFECRARGA-DILAYPPVVAGGN 308 E+E ++ K++S+A E M K ++E L + FE C +RG +Y + G Sbjct: 185 MELEVLRYTNKISSEAHREVMKAVKVGMKEYELESLFEHYCYSRGGMRHSSYTCICGSGE 244 Query: 309 RSNTLHY----VKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGRFTAPQAELYEAV 364 S LHY N++ I++G+M L D G E C+ SDIT ++P NG+FTA Q +YEAV Sbjct: 245 NSAVLHYGHAGAPNDRTIQNGDMCLFDMGGEYYCFASDITCSFPANGKFTADQKAVYEAV 304 Query: 365 LEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMK-NIKENNAFKAARKYCPHHVG 423 L R + PG +++ + + ++L +GI+ ++ + PH +G Sbjct: 305 LRSSRAVMGAMKPGVWWPDMHRLADRIHLEELAHMGILSGSVDAMVQAHLGAVFMPHGLG 364 Query: 424 HYLGMDVHDTPDMP-----------RSL----PLQPGMVITIEPGIYIPED--------- 459 H+LG+DVHD P RSL LQPGMV+T+EPGIY + Sbjct: 365 HFLGIDVHDVGGYPEGVERIDEPGLRSLRTARHLQPGMVLTVEPGIYFIDHLLDEALADP 424 Query: 460 ------DKDAPEKFRGL-GVRIEDDVVVTQDSPLILSADCPKEMNDIE 500 +++ ++FRG GVRIED VV DS + L P+ + +IE Sbjct: 425 ARASFLNREVLQRFRGFGGVRIED--VVVTDSGIELLTCVPRTVEEIE 470 >3Q6D-A nrPDB Length = 356 Score = 117 bits (293), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 85/261 (32%), Positives = 134/261 (51%), Gaps = 33/261 (12%) Query: 239 LIQRLRLIKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKFEFECRARGADIL 298 L+++LRLIK+ +EI+ ++ A ++ AF + + V E + + EF R +GA Sbjct: 123 LVEKLRLIKTDSEIKILKEAAQIADAAFEHILSFIRPGVSEIEVSNELEFFMRKQGATSS 182 Query: 299 AYPPVVAGGNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGRFTAPQA 358 ++ +VA G RS H V + ++I+ G+ V LD G Y SDITRT V G + Sbjct: 183 SFDIIVASGLRSALPHGVASEKVIETGDFVTLDFGAYYKGYCSDITRTIAV-GEPSDKLK 241 Query: 359 ELYEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMKNIKENNAFKAARKYC 418 E+Y VLE Q L + + L G++ L ++ K +Y Sbjct: 242 EIYNIVLEAQ------------LRGVNGIKAGLTGREADAL-----TRDYITEKGYGEYF 284 Query: 419 PHHVGHYLGMDVHDTPDMP-RS-LPLQPGMVITIEPGIYIPEDDKDAPEKFRGL-GVRIE 475 H GH +G+++H+ P + RS L+PGM +T+EPGIYIP G+ GVRIE Sbjct: 285 GHSTGHGIGLEIHEAPGLAFRSDTVLEPGMAVTVEPGIYIP-----------GIGGVRIE 333 Query: 476 DDVVVTQDSPLILSADCPKEM 496 DD++VT + +++ PKE+ Sbjct: 334 DDIIVTSEGNEVIT-KSPKEL 353 >1PV9-A nrPDB Length = 348 Score = 114 bits (286), Expect = 8e-26, Method: Compositional matrix adjust. Identities = 84/262 (32%), Positives = 137/262 (52%), Gaps = 31/262 (11%) Query: 226 KAKSKNK-VRGVQQLIQRLRLIKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFLYA 284 K KS K + + +I+ LR+IK+ EIE ++ A ++ +A + + E + A Sbjct: 103 KEKSNVKEFKKIDDVIKDLRIIKTKEEIEIIEKACEIADKAVMAAIEEITEGKREREVAA 162 Query: 285 KFEFECRARGADILAYPPVVAGGNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDIT 344 K E+ + GA+ A+ ++A G+RS H V +++ I+ G++V++D G + Y SDIT Sbjct: 163 KVEYLMKMNGAEKPAFDTIIASGHRSALPHGVASDKRIERGDLVVIDLGALYNHYNSDIT 222 Query: 345 RTWPVNGRFTAPQAELYEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMKN 404 RT V G Q E+YE VLE Q+ + PG + + + S+ +I K+ G Sbjct: 223 RTIVV-GSPNEKQREIYEIVLEAQKRAVEAAKPGMTAKELDSIAREII----KEYG---- 273 Query: 405 IKENNAFKAARKYCPHHVGHYLGMDVHDTPDMPR--SLPLQPGMVITIEPGIYIPEDDKD 462 Y H +GH +G+++H+ P + + L+ GMVITIEPGIYIP Sbjct: 274 ---------YGDYFIHSLGHGVGLEIHEWPRISQYDETVLKEGMVITIEPGIYIP----- 319 Query: 463 APEKFRGLGVRIEDDVVVTQDS 484 + GVRIED V++T++ Sbjct: 320 -----KLGGVRIEDTVLITENG 336 >1WY2-A nrPDB Length = 351 Score = 114 bits (286), Expect = 8e-26, Method: Compositional matrix adjust. Identities = 82/265 (30%), Positives = 137/265 (51%), Gaps = 31/265 (11%) Query: 222 LTEAKAKSKNK-VRGVQQLIQRLRLIKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEA 280 + E K K+ K + V +I+ +R+IKS EI+ ++ A ++ +A + + +E Sbjct: 102 IEELKKKANIKEFKKVDDVIRDMRIIKSEKEIKIIEKACEIADKAVMAAIEEITEGKKER 161 Query: 281 FLYAKFEFECRARGADILAYPPVVAGGNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYV 340 + AK E+ + GA+ A+ ++A G RS H V +++ I+ G++V++D G Y Sbjct: 162 EVAAKVEYLMKMNGAEKPAFDTIIASGYRSALPHGVASDKRIERGDLVVIDLGALYQHYN 221 Query: 341 SDITRTWPVNGRFTAPQAELYEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLG 400 SDITRT V G Q E+YE VLE Q+ + PG + + + S+ +I + Sbjct: 222 SDITRTIVV-GSPNEKQKEIYEIVLEAQKKAVESAKPGITAKELDSIARNIIAE------ 274 Query: 401 IMKNIKENNAFKAARKYCPHHVGHYLGMDVHDTPDMPR--SLPLQPGMVITIEPGIYIPE 458 +Y H +GH +G++VH+ P + + L+ GMVITIEPGIYIP+ Sbjct: 275 -----------YGYGEYFNHSLGHGVGLEVHEWPRVSQYDETVLREGMVITIEPGIYIPK 323 Query: 459 DDKDAPEKFRGLGVRIEDDVVVTQD 483 GVRIED +++T++ Sbjct: 324 IG----------GVRIEDTILITKN 338 >4ZNG-C nrPDB Length = 362 Score = 114 bits (284), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 80/251 (31%), Positives = 124/251 (49%), Gaps = 34/251 (13%) Query: 239 LIQRLRLIKSPAEIERMQIAGKLTSQAFIETMFTSKAP---VEEAFLYAKFEFECRARGA 295 LI+R+RLIKS EIE+M++AG + F E F + A V E+ + AK E+E + G Sbjct: 127 LIERMRLIKSADEIEKMKVAGDFADKCF-EIGFATAAERNGVTESDIVAKIEYEMKRMGV 185 Query: 296 DILAYPPVVAGGNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGRFTA 355 +++ +V G R+ H N I++ +++L D G S Y SD TRT + G+ Sbjct: 186 PQMSFDTLVLSGARAANPHGAPENVEIQENKLLLFDLGVMSGGYASDATRTIAI-GQPND 244 Query: 356 PQAELYEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMKNIKENNAFKAAR 415 AE+++ V E Q+ + PG + + ++ LI + Sbjct: 245 FDAEIHKIVKEAQQAAMDFIKPGVTAHEVDAVARDLITK-----------------AGYG 287 Query: 416 KYCPHHVGHYLGMDVHDTPDM--PRSLPLQPGMVITIEPGIYIPEDDKDAPEKFRGLGVR 473 +Y H +GH +GMDVH+ P + L +Q GM + EPGIYIP +GVR Sbjct: 288 EYFNHRLGHGIGMDVHEYPSIVAGNDLVIQEGMCFSNEPGIYIPGK----------VGVR 337 Query: 474 IEDDVVVTQDS 484 IED + VT++ Sbjct: 338 IEDCLYVTENG 348 >5CNX-A nrPDB Length = 361 Score = 108 bits (271), Expect = 4e-24, Method: Compositional matrix adjust. Identities = 78/254 (30%), Positives = 124/254 (48%), Gaps = 33/254 (12%) Query: 243 LRLIKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKFEFECRARGADILAYPP 302 LR IK+P E+E++++A + + +A + E + A+ E+ R +GA+ ++ Sbjct: 124 LRQIKTPEEVEKIRLACGIADRGAEHIRRFIQAGMSEREIAAELEWFMRQQGAEKASFDT 183 Query: 303 VVAGGNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGRFTAPQAEL-- 360 +VA G R H +++++ GE V LD G Y SD+TRT VNG + ++ L Sbjct: 184 IVASGWRGALPHGKASDKIVAAGEFVTLDFGALYQGYCSDMTRTLLVNGEGVSAESHLLF 243 Query: 361 --YEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMKNIKENNAFKAARKYC 418 Y+ VL+ Q ++ PG + + D + I E Y Sbjct: 244 NVYQIVLQAQLAAISAIRPGVRCQQV-------------DDAARRVITE----AGYGDYF 286 Query: 419 PHHVGHYLGMDVHDTPDM-PR-SLPLQPGMVITIEPGIYIPEDDKDAPEKFRGLGVRIED 476 H+ GH +G++VH+ P PR + LQPGM++T+EPGIY+P GVRIED Sbjct: 287 GHNTGHAIGIEVHEDPRFSPRDTTTLQPGMLLTVEPGIYLPGQG----------GVRIED 336 Query: 477 DVVVTQDSPLILSA 490 V+VT +L A Sbjct: 337 VVLVTPQGAEVLYA 350 >2ZSG-A nrPDB Length = 359 Score = 107 bits (266), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 76/267 (28%), Positives = 137/267 (51%), Gaps = 30/267 (11%) Query: 225 AKAKSKNKVRGVQQLIQRLRLIKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFLYA 284 + A K G+ ++++R++K EIE+++ A +++ +AF+ET+ +A + E + A Sbjct: 112 SSAFGDRKFIGIDDEVKQMRMVKDEGEIEKIKQAIEISERAFLETVQQIRAGMTEKEIAA 171 Query: 285 KFEFECRARGADILAYPPVVAGGNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDIT 344 E+ R GA+ +A+ +VA G RS H ++++++ G+++++D G Y +DIT Sbjct: 172 LLEYTMRKEGAEGVAFDTIVASGCRSALPHGKASDKVVERGDVIVIDFGATYENYCADIT 231 Query: 345 RTWPVNGRFTAPQAELYEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMKN 404 R + G + E++ VLE Q L + G + KL D + Sbjct: 232 RVVSI-GEPSDEVKEVHSIVLEAQERALKIAKAGVT-------------GKLLDSVAREF 277 Query: 405 IKENNAFKAARKYCPHHVGHYLGMDVHDTPDMP--RSLPLQPGMVITIEPGIYIPEDDKD 462 I+E K ++ H +GH +G++VH+ P + PL +V T+EPGIY+ Sbjct: 278 IRE----KGYGEFFGHSLGHGIGLEVHEGPAISFRNDSPLPENVVFTVEPGIYL------ 327 Query: 463 APEKFRGLGVRIEDDVVVTQDSPLILS 489 KF G+RIE+DVV+ + IL+ Sbjct: 328 -EGKF---GIRIEEDVVLKEQGCEILT 350 >4RGZ-A nrPDB Length = 367 Score = 86.7 bits (213), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 74/260 (28%), Positives = 116/260 (44%), Gaps = 37/260 (14%) Query: 236 VQQLIQRLRLIKSPAEIERMQIAGKLTSQAF---IETMFTSKAPVEEAFLYAKFEFECRA 292 + +I LR IK EI+ + A ++ + F IE K+ E L + E+ + Sbjct: 130 ISPVISELREIKDKDEIKAHKKAAEIVDKVFYRFIEGKLEGKSERE---LANRIEYMIKN 186 Query: 293 R-GADILAYPPVVAGGNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNG 351 GAD +++ P+VA G H+ +++ I+ G++V+ D G + Y SD+TRT V G Sbjct: 187 EFGADDVSFEPIVASGPNGANPHHRPSHRKIRKGDVVIFDYGAKYLGYCSDVTRTVVV-G 245 Query: 352 RFTAPQAELYEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMKNIKENNAF 411 + ++YE V E Q + G E + + +I + Sbjct: 246 PPSEEVKKVYEIVKEAQETAVQKVAEGIPAEVVDATARGIISK----------------- 288 Query: 412 KAARKYCPHHVGHYLGMDVHDTPDMP--RSLPLQPGMVITIEPGIYIPEDDKDAPEKFRG 469 +Y H GH LG+DVH+ P + L+ GMV TIEPGIY+ Sbjct: 289 YGYGEYFIHRTGHGLGIDVHEEPYISPGNKKILKDGMVFTIEPGIYLQGK---------- 338 Query: 470 LGVRIEDDVVVTQDSPLILS 489 GVRIEDDV + + L+ Sbjct: 339 FGVRIEDDVALVDKKGIRLT 358 >4QR8-A nrPDB Length = 443 Score = 82.4 bits (202), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 82/296 (27%), Positives = 124/296 (41%), Gaps = 57/296 (19%) Query: 234 RGVQQLIQRLRLIKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKFEFECRA- 292 +GV + R K+ E+ M+ A K+ EEAF EF+ Sbjct: 149 KGVIDYLHYYRSFKTEYELACMREAQKMA--------VNGHRAAEEAFRSGMSEFDINIA 200 Query: 293 -------RGADILAYPPVVAGGNRSNTLHYVK-NNQLIKDGEMVLLDGGCESSCYVSDIT 344 R D+ Y +VA + LHY K ++Q ++ LLD G E + Y +D+T Sbjct: 201 YLTATGHRDTDV-PYSNIVALNEHAAVLHYTKLDHQAPEEMRSFLLDAGAEYNGYAADLT 259 Query: 345 RTWPVNGRFTAPQAELYEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMKN 404 RTW + + A+L + V + Q +A G S + + I + L+ I+ + Sbjct: 260 RTW--SAKSDNDYAQLVKDVNDEQLALIATMKAGVSYVDYHIQFHQRIAKLLRKHQIITD 317 Query: 405 IKENNAFKA--ARKYCPHHVGHYLGMDVHDTPDM-----------PRSLP-------LQP 444 + E + + PH +GH LG+ VHD P P LQP Sbjct: 318 MSEEAMVENDLTGPFMPHGIGHPLGLQVHDVAGFMQDDSGTHLAAPAKYPYLRCTRILQP 377 Query: 445 GMVITIEPGIYIPEDDKDAP------------EKFRGL----GVRIEDDVVVTQDS 484 GMV+TIEPGIY E AP +K L G+RIED+VV+ +++ Sbjct: 378 GMVLTIEPGIYFIE-SLLAPWREGQFSKHFNWQKIEALKPFGGIRIEDNVVIHENN 432 >3RVA-A nrPDB Length = 451 Score = 79.7 bits (195), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 79/302 (26%), Positives = 128/302 (42%), Gaps = 57/302 (18%) Query: 236 VQQLIQRLRLIKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKFEFE------ 289 V + R K+ E++ M+ A KL E+AF K EF+ Sbjct: 149 VLHYLHYQRAYKTDYELDCMREANKLA--------VAGHKAAEQAFREGKSEFDINLAYA 200 Query: 290 -CRARGADILAYPPVVAGGNRSNTLHYVKNNQLI-KDGEMVLLDGGCESSCYVSDITRTW 347 +G + + Y +VA ++ LHY++ + + K+ L+D G Y +DITRT+ Sbjct: 201 AASRQGDNDVPYTSIVALNEHASILHYMQCDTVAPKESRSFLIDAGANYHGYAADITRTY 260 Query: 348 PVNG-RFTAPQAELYEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMKNIK 406 G +A +L +AV ++ + PG + +I+ + I Q L D G M N+ Sbjct: 261 AQEGVHNSAMFRDLIQAVDKVTLTLVDSLKPGVAYTDIHLLAHDGIAQILHDTG-MVNLT 319 Query: 407 --ENNAFKAARKYCPHHVGHYLGMDVHDTPDM-------PRSLP-----------LQPGM 446 E R + PH +GH+LG+ VHD + P+ P ++ Sbjct: 320 PPEIVEMGITRTFFPHGIGHFLGLQVHDVGGLVNDDRGTPKPAPDDHPFLRCTRMVEARQ 379 Query: 447 VITIEPGI-----------------YIPEDDKDAPEKFRGLGVRIEDDVVVTQDSPLILS 489 V TIEPG+ YI D DA + F G+RIED+++V +D ++ Sbjct: 380 VFTIEPGLYFIDSLLRDLKATPASKYINWDTIDAYKPFG--GIRIEDNIIVHRDKNENMT 437 Query: 490 AD 491 D Sbjct: 438 RD 439 >4ZWP-A nrPDB Length = 440 Score = 70.1 bits (170), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 75/297 (25%), Positives = 117/297 (39%), Gaps = 64/297 (21%) Query: 236 VQQLIQRLRLIKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKFEFECRARGA 295 V R K+ E+ M+ A K+ Q +AF K EFE + A Sbjct: 149 VMNFYHYHRAYKTQYELACMREANKIAVQG--------HKAARDAFFQGKSEFEIQQ--A 198 Query: 296 DILA---------YPPVVAGGNRSNTLHYVKNNQLI-KDGEMVLLDGGCESSCYVSDITR 345 +LA + +VA LHY +++ L+D G + Y +DITR Sbjct: 199 YLLATQHSENDTPFGNIVALNENCAILHYTHFDRVAPATHRSFLIDAGANFNGYAADITR 258 Query: 346 TWPVNGRFTAPQAELYEAVLEIQRDCLALC---FPGTSLENIYSMMLTLIGQKLKDLGIM 402 T+ G + E E V +++ +ALC PG ++ + Q L D I+ Sbjct: 259 TYDFTG-----EGEFAELVATMKQHQIALCNQLAPGKLYGELHLDCHQRVAQTLSDFNIV 313 Query: 403 K-NIKENNAFKAARKYCPHHVGHYLGMDVHDT------------------PDMPRSLPLQ 443 + E A + PH +GH++G+ VHD P + + ++ Sbjct: 314 NLSADEIVAKGITSTFFPHGLGHHIGLQVHDVGGFMADEQGAHQEPPEGHPFLRCTRKIE 373 Query: 444 PGMVITIEPGIYIPED----------------DKDAPEKFRGLGVRIEDDVVVTQDS 484 V TIEPG+Y + DK A K G G+RIED+++V +DS Sbjct: 374 ANQVFTIEPGLYFIDSLLGDLAATDNNQHINWDKVAELKPFG-GIRIEDNIIVHEDS 429 >3L7G-A nrPDB Length = 517 Score = 67.8 bits (164), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 75/297 (25%), Positives = 116/297 (39%), Gaps = 64/297 (21%) Query: 236 VQQLIQRLRLIKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKFEFECRARGA 295 V R K+ E+ M+ A K+ Q +AF K EFE + A Sbjct: 149 VMNFYHYHRAYKTQYELACMREANKIAVQG--------HKAARDAFFQGKSEFEIQQ--A 198 Query: 296 DILA---------YPPVVAGGNRSNTLHYVKNNQLI-KDGEMVLLDGGCESSCYVSDITR 345 +LA Y +VA LHY +++ L+D G + Y +DITR Sbjct: 199 YLLATQHSENDNPYGNIVALNENCAILHYTHFDRVAPATHRSFLIDAGANFNGYAADITR 258 Query: 346 TWPVNGRFTAPQAELYEAVLEIQRDCLAL---CFPGTSLENIYSMMLTLIGQKLKDLGIM 402 T+ G + E E V +++ +AL PG ++ + Q L D I+ Sbjct: 259 TYDFTG-----EGEFAELVATMKQHQIALMNQLAPGKLYGELHLDCHQRVAQTLSDFNIV 313 Query: 403 K-NIKENNAFKAARKYCPHHVGHYLGMDVHDT------------------PDMPRSLPLQ 443 + E A + PH +GH++G+ VHD P + + ++ Sbjct: 314 DLSADEIVAKGITSTFFPHGLGHHIGLQVHDVGGFMADEQGAHQEPPEGHPFLRCTRKIE 373 Query: 444 PGMVITIEPGIYIPED----------------DKDAPEKFRGLGVRIEDDVVVTQDS 484 V TIEPG+Y + DK A K G G+RIED+++V +DS Sbjct: 374 ANQVFTIEPGLYFIDSLLGDLAATDNNQHINWDKVAELKPFG-GIRIEDNIIVHEDS 429 >4FO7-A nrPDB Length = 280 Score = 57.0 bits (136), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 66/264 (25%), Positives = 112/264 (42%), Gaps = 40/264 (15%) Query: 246 IKSPAEIERMQIAGKLTSQAF------IETMFTSKAPVEEAFLYAKFEFECRARGADILA 299 IK+P +IE+M+IAG+L ++ I+ T++ Y E + + Sbjct: 5 IKTPDDIEKMRIAGRLAAEVLEMIGEHIKPGVTTEELDRICHDYIVNEQKAIPAPLNYKG 64 Query: 300 YPPVVAGGNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGRFTAPQAE 359 +P + H + N + +K+G+++ +D Y D ++ + V E Sbjct: 65 FPKSICTSINHVVCHGIPNEKPLKEGDILNVDITVIKDGYHGDTSKMFLV-----GKTPE 119 Query: 360 LYEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLG-IMKNIKENNAFKAARKYC 418 + + +I ++C+ + G S + G L D+G I++ E N F R+YC Sbjct: 120 WADRLCQITQECM---YKGIS--------VVRPGAHLGDIGEIIQKHAEKNGFSVVREYC 168 Query: 419 PHHVGHYLGMDVHDTPDM------PRSLPLQPGMVITIEPGIY--IPE-----DDKDAPE 465 GH +G H+ P + + L+ GM+ TIEP I PE D A Sbjct: 169 ----GHGIGKVFHEEPQVLHYGRAGTGIELKEGMIFTIEPMINQGRPETRLLGDGWTAIT 224 Query: 466 KFRGLGVRIEDDVVVTQDSPLILS 489 K R L + E V+VT D IL+ Sbjct: 225 KDRKLSAQWEHTVLVTADGYEILT 248 >6MRF-A nrPDB Length = 270 Score = 52.0 bits (123), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 67/278 (24%), Positives = 113/278 (40%), Gaps = 56/278 (20%) Query: 245 LIKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKFEFECRARGADIL-AYPPV 303 +IK+P EIE+M+IAG+L + E + K ++ + + CR ++ A P Sbjct: 9 MIKTPDEIEKMRIAGRLAA----EVLDMIKPHIKAGVSTLELDTICRNHIENVQHAIPAC 64 Query: 304 VAGGNR-----------SNTLHYV-----KNNQLIKDGEMVLLDGGCESSCYVSDITRTW 347 V G ++ H V N+++K+G+++ +D Y D + Sbjct: 65 VGYGGAPGRPAFQHSICTSVNHVVCHGIPSENKILKNGDILNIDVTVIKDGYHGDTNMMY 124 Query: 348 PVNGRFTAPQAELYEAVLEIQRDCLALCFPGTSLENIYSMMLTL-IGQKLKDLG-IMKNI 405 V G E + R C + E +Y M T+ G L D+G ++ Sbjct: 125 IVGG----------ETSILANRLC------KVAQEAMYRGMATVRDGSYLGDIGHAIQKY 168 Query: 406 KENNAFKAARKYCPHHVGHYLGMDVHDTPDM------PRSLPLQPGMVITIEP----GIY 455 E+ F R+YC GH +G HD P + + L+ GM TIEP G++ Sbjct: 169 VESERFSVVREYC----GHGIGTVFHDEPQVLHYGQAGTGMRLEAGMTFTIEPMVNAGVW 224 Query: 456 ---IPEDDKDAPEKFRGLGVRIEDDVVVTQDSPLILSA 490 + D K L + E ++VT+ +L+A Sbjct: 225 QTKLLGDKWTVVTKDHKLSAQYEHTILVTKTGIEVLTA 262 >4A6V-A nrPDB Length = 265 Score = 51.6 bits (122), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 64/264 (24%), Positives = 103/264 (39%), Gaps = 39/264 (14%) Query: 246 IKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFL------YAKFEFECRARGADILA 299 IK+P +IE+M++AG+L ++ K V L Y E + Sbjct: 5 IKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHG 64 Query: 300 YPPVVAGGNRSNTLHYVKNN-QLIKDGEMVLLDGGCESSCYVSDITRTWPVNGRFTAPQA 358 YP V H + ++ +L+KDG++V +D + D ++ + V G+ T Sbjct: 65 YPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIV-GKPTIMGE 123 Query: 359 ELYEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMKNIKENNAFKAARKYC 418 L E L + PG +L I + + + E F R+YC Sbjct: 124 RLCRITQESLYLALRMVKPGINLREIGAAIQKFV--------------EAEGFSVVREYC 169 Query: 419 PHHVGHYLGMDVHDTPDM------PRSLPLQPGMVITIEP-------GIYIPEDDKDAPE 465 GH +G H+ P + ++ L+PGM TIEP I +D Sbjct: 170 ----GHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKT 225 Query: 466 KFRGLGVRIEDDVVVTQDSPLILS 489 K R L + E +VVT + IL+ Sbjct: 226 KDRSLSAQYEHTIVVTDNGCEILT 249 >3TB5-A nrPDB Length = 264 Score = 49.3 bits (116), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 62/278 (22%), Positives = 107/278 (38%), Gaps = 67/278 (24%) Query: 246 IKSPAEIERMQIAGKLTS-------------------QAFIETMFTSKAPVEEAFLYAKF 286 +KSP EIE M +G+L + + F+ S V Y + Sbjct: 4 LKSPREIEMMDESGELLADVHRHLRTFIKPGITSWDIEVFVRDFIESHGGVAAQIGYEGY 63 Query: 287 EFECRARGADILAYPPVVAGGNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRT 346 ++ D + + G R L K+ LIK V L G SC+ + + Sbjct: 64 KYATCCSINDEICH-----GFPRKKVL---KDGDLIKVDMCVDLKGAISDSCWSYVVGES 115 Query: 347 WPVNGRFTAPQAELYEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLG-IMKNI 405 P R +E+ + L L + +G ++ D+G ++ Sbjct: 116 TPEIDRL-----------MEVTKKALYL-----------GIEQAQVGNRIGDIGHAIQTY 153 Query: 406 KENNAFKAARKYCPHHVGHYLGMDVHDTPDMP------RSLPLQPGMVITIEP----GIY 455 E + R + VGH +G +H++P +P + L L+ GMVITIEP G + Sbjct: 154 VEGEGYGVVRDF----VGHGIGPTIHESPMIPHYGEAGKGLRLKEGMVITIEPMVNTGTW 209 Query: 456 IPEDDKDAPEKFR---GLGVRIEDDVVVTQDSPLILSA 490 + D + + GL + E + +T++ P IL++ Sbjct: 210 RMKMDPNGWTAYTEDGGLSCQYEHSLAITKEGPRILTS 247 >4KM3-A nrPDB Length = 286 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 66/283 (23%), Positives = 111/283 (39%), Gaps = 45/283 (15%) Query: 246 IKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKFEFECRAR-------GAD-- 296 +KS EIE M AG + I K V+ + C+ G D Sbjct: 4 LKSAREIEAMDKAGDFLASIHIGLRDLIKPGVDMWEVEEYVRRRCKEENFLPLQIGVDGA 63 Query: 297 ILAYPPVVAGGNRSNTLHYVKNNQLIKDGEMVLLD---GG--CESSCYVSDITRTWPVNG 351 ++ YP H + ++KDG+++ +D GG +S VS + N Sbjct: 64 MMDYPYATCCSLNDEVAHAFPRHYILKDGDLLKVDMVLGGPIAKSDLNVSKLNFN---NV 120 Query: 352 RFTAPQAELYEAVLEIQRDCLALCFPGTSLENIYSMM---------LTLIGQKLKDLGI- 401 + Y L A+ P ++N+ + ++G ++ D+G Sbjct: 121 EQMKKYTQSYSGGLADSCWAYAVGTPSEEVKNLMDITKEAMYKGIEQAVVGNRIGDIGAA 180 Query: 402 MKNIKENNAFKAARKYCPHHVGHYLGMDVHDTPDMP------RSLPLQPGMVITIEPGIY 455 ++ E+ + R VGH +G +H+ P +P R L L+ GMV+TIEP I Sbjct: 181 IQEYAESRGYGVVRDL----VGHGVGPTMHEEPMVPNYGIAGRGLRLREGMVLTIEPMIN 236 Query: 456 IPEDDKDAPEKF--------RGLGVRIEDDVVVTQDSPLILSA 490 + + D K GL + E V+T+D P+IL++ Sbjct: 237 TGDWEIDTDMKTGWAHKTIDGGLSCQYEHQFVITKDGPVILTS 279 >3CTZ-A nrPDB Length = 623 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 64/254 (25%), Positives = 104/254 (40%), Gaps = 47/254 (18%) Query: 244 RLIKSPAEIERMQIAGKLTSQAFIETMF-----TSKAPVEEAFLYAKFEFECRARGADI- 297 + +K+ AE E M+ A + A E K V E K E E R + AD Sbjct: 319 KAVKNSAESEGMRRAHIKDAVALCELFNWLEKEVPKGGVTEISAADKAE-EFRRQQADFV 377 Query: 298 -LAYPPVVAGGNRSNTLHYV---KNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGRF 353 L++P + + G +HY + N+ + E+ L+D G + +D+TRT Sbjct: 378 DLSFPTISSTGPTGAIIHYAPVPETNRTLSLDEVYLIDSGAQYKDGTTDVTRTMHFETP- 436 Query: 354 TAPQAELYEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMKNIKENNAFKA 413 TA + E + VL+ A FP + + ++ + + + + Sbjct: 437 TAYEKECFTYVLKGHIAVSAAVFPTGTKGH-----------------LLDSFARSALWDS 479 Query: 414 ARKYCPHHVGHYLG--MDVHDTP-----DMPRSLPLQPGMVITIEPGIYIPEDDKDAPEK 466 Y H GH +G ++VH+ P PL+ GM++T EPG Y ED Sbjct: 480 GLDYL-HGTGHGVGSFLNVHEGPCGISYKTFSDEPLEAGMIVTDEPGYY--EDG------ 530 Query: 467 FRGLGVRIEDDVVV 480 G+RIE+ V+V Sbjct: 531 --AFGIRIENVVLV 542 >1O0X-A nrPDB Length = 262 Score = 45.4 bits (106), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 53/223 (23%), Positives = 88/223 (39%), Gaps = 39/223 (17%) Query: 246 IKSPAEIERMQIAGKLTSQAFIE---------TMFTSKAPVEEAFLYAKFEFECRARGAD 296 IK+P+EIE+M+ AGK + A E T + + V E F K + +G Sbjct: 16 IKTPSEIEKMKKAGKAVAVALREVRKVIVPGKTAWDVETLVLEIF--KKLRVKPAFKGYG 73 Query: 297 ILAYPPVVAGGNRSNTLHYV-KNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGRFTA 355 Y V+ +H + ++ K+G++V +D G D T+ V G Sbjct: 74 GYKYATCVS--VNEEVVHGLPLKEKVFKEGDIVSVDVGAVYQGLYGDAAVTYIV-GETDE 130 Query: 356 PQAELYEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMKNIKENNAFKAAR 415 EL E+ + + PG L ++ + + E+ F R Sbjct: 131 RGKELVRVTREVLEKAIKMIKPGIRLGDVSHCIQETV--------------ESVGFNVIR 176 Query: 416 KYCPHHVGHYLGMDVHDTPDMPR------SLPLQPGMVITIEP 452 Y VGH +G ++H+ P +P + L+ GM + IEP Sbjct: 177 DY----VGHGVGRELHEDPQIPNYGTPGTGVVLRKGMTLAIEP 215 >1QXW-A nrPDB Length = 252 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 44/190 (23%), Positives = 82/190 (43%), Gaps = 32/190 (16%) Query: 314 HYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGRFTAPQAELYEAVLEIQRDCLA 373 H + + ++I++G++V +D + Y +D ++ V + ++ + + +A Sbjct: 76 HGIPSKRVIREGDLVNIDVSALKNGYYADTGISFVVGESDDPMKQKVCDVATMAFENAIA 135 Query: 374 LCFPGTSLENIYSMMLTLIGQKLKDLGIMKNIKENNAFKAARKYCPHHVGHYLGMDVHDT 433 PGT L NI + Q DL ++KN+ GH +G+ +H+ Sbjct: 136 KVKPGTKLSNIGKAVHNTARQN--DLKVIKNL----------------TGHGVGLSLHEA 177 Query: 434 P-------DMPRSLPLQPGMVITIEPGI-----YIPEDDKD-APEKF-RGLGVRIEDDVV 479 P D L GMV+ IEP I ++ E + A E + +IE V+ Sbjct: 178 PAHVLNYFDPKDKTLLTEGMVLAIEPFISSNASFVTEGKNEWAFETSDKSFVAQIEHTVI 237 Query: 480 VTQDSPLILS 489 VT+D P++ + Sbjct: 238 VTKDGPILTT 247 >4S2R-P nrPDB Length = 639 Score = 43.1 bits (100), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 66/260 (25%), Positives = 103/260 (39%), Gaps = 54/260 (20%) Query: 239 LIQRLRLIKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKFEFECRARGAD-- 296 L+Q + K+ E++ M+ + S A +E + + + Y + E + Sbjct: 333 LVQTAKATKNDHEMQGMRNSHLRDSAALVEFLCWLEKELLSGKRYTEIELADKIDHLRSL 392 Query: 297 -----ILAYPPVVAGGNRSNTLHYV----KNNQLIKDGEMVLLDGGCESSCYVSDITRT- 346 L++ + A G+ + HY N+ ++ LLD G +D+TRT Sbjct: 393 QDKYVTLSFDTISAVGDHAALPHYKPLGESGNRKAAANQVFLLDSGAHYGDGTTDVTRTV 452 Query: 347 WPVNGRFTAPQAELY---EAVLEIQRDCLALCFPGTSLENIY-SMMLTLIGQKLKDLGIM 402 W +T P E VL+ + FP + IY S + TL L LG+ Sbjct: 453 W-----YTNPPKEFILHNTLVLKGHINLARAKFP----DGIYGSRLDTLTRDALWKLGL- 502 Query: 403 KNIKENNAFKAARKYCPHHVGHYLGMDVHDTP------DMPRSLPLQPGMVITIEPGIYI 456 F+ H VGHYL +VH+ P +P L V+TIEPG Y Sbjct: 503 -------DFEHG---TGHGVGHYL--NVHEGPIGIGHRSVPTGGELHASQVLTIEPGFY- 549 Query: 457 PEDDKDAPEKFRGLGVRIED 476 A EK+ G+RIE+ Sbjct: 550 ------AKEKY---GIRIEN 560 >5CE6-A nrPDB Length = 480 Score = 42.4 bits (98), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 67/310 (21%), Positives = 122/310 (39%), Gaps = 47/310 (15%) Query: 121 FLYLCGFQEPDSILVLQSLPGKQLPSHK-AILFVPRRDPSRE-------LWDGPRSGTDG 172 FL+L GF+ P++I+V L S K A + + P+RE L P++ DG Sbjct: 74 FLWLLGFEFPETIMVFTKKQIHVLCSQKKASILESVKKPARESVGVEIILHVKPKND-DG 132 Query: 173 AIALTGVDEAYTLEEFQHLLPKMKAETNMVWYDWMRPSH---AQLHSDYMQPLTEAKAKS 229 A ++ + A ++A++ +D H + + E S Sbjct: 133 ASSMDAIIRA------------IRAQSKSDGHDSSTVGHIAREEPEGRLLDLWAEKLKNS 180 Query: 230 KNKVRGVQQLIQRLRLIKSPAEIERMQIAGKLTS---QAFIETMFTSKAPVEEAFLY--- 283 K ++ V L KS EI ++ A LT + F+ T + E+ L+ Sbjct: 181 KFRLSDVANGFSALFAAKSNEEITYIKRAAYLTGSVMKNFVVTKLENVIDEEKKILHSTL 240 Query: 284 -----------AKFEFECRARGADILAYPPVVAGGNRSNTL-HYVKNNQLI--KDGEMVL 329 AK + +A DI YPP+ G + + V N++ + +++ Sbjct: 241 MEETEKVILDPAKVNCKLKADNVDI-CYPPIFQSGGKFDLRPSAVSNDEALYYDSASVII 299 Query: 330 LDGGCESSCYVSDITRTWPVNGRFTAPQAELYEAVLEIQRDCLALCFPGTSLENIYSMML 389 G Y S+I RT+ ++ Q++ YE +L+ Q + PG L Y + Sbjct: 300 CAVGARYKSYCSNIARTFLIDA--DPIQSKAYEVLLKAQEAVIGSLKPGNKLSAAYLAAV 357 Query: 390 TLIGQKLKDL 399 +++ + D+ Sbjct: 358 SVVEKDAPDM 367 >5JR6-A nrPDB Length = 664 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 63/254 (24%), Positives = 104/254 (40%), Gaps = 47/254 (18%) Query: 240 IQRLRLIKSPAEIERMQIAGKLTSQAFIETMF--TSKAPVEEAF------LYAKFEFECR 291 + +++ +K+ EI+ M+ A L A ++ K +E F L K ++ Sbjct: 349 VVKMKAVKNDVEIDNMKQAHILDGLALLQFFHWCEQKRKTKELFNETEMSLRHKVDYFRS 408 Query: 292 ARGADIL-AYPPVVAGGNRSNTLHYV---KNNQLIKDGEMVLLDGGCESSCYVSDITRTW 347 + I ++ + A G + +HY K N IK + LLD G + +D+TRT Sbjct: 409 TKKNFIFPSFSTISASGPNAAVIHYECTDKTNATIKPA-IYLLDSGGQYLHGTTDVTRTT 467 Query: 348 PVNGRFTAPQAELYEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMKNIKE 407 G TA + +Y VL+ + F + S L I ++ Sbjct: 468 HF-GEPTAEEKRIYTLVLKGHLRLRKVIFASYT----NSSALDFIARE------------ 510 Query: 408 NNAFKAARKYCPHHVGHYLGM--DVHD---TPDMPRSLPLQPGMVITIEPGIYIPEDDKD 462 N F Y H GH +G+ +VH+ + PL+ MV++ EPG Y+ Sbjct: 511 -NLFNNFMDY-NHGTGHGVGLTLNVHEGGCSIGPVGGAPLKKNMVLSNEPGYYM------ 562 Query: 463 APEKFRGLGVRIED 476 +KF GVRIE+ Sbjct: 563 -KDKF---GVRIEN 572 >2B3K-A nrPDB Length = 329 Score = 36.2 bits (82), Expect = 0.038, Method: Compositional matrix adjust. Identities = 48/240 (20%), Positives = 90/240 (37%), Gaps = 37/240 (15%) Query: 227 AKSKNKVRGVQQLIQRLRLIKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKF 286 ++S+ ++G Q+ +L+ S +IE M++ +L + K V + Sbjct: 61 SESEQALKGTSQI----KLLSS-EDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAV 115 Query: 287 EFECRARGA-----DILAYPPVVAGGNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYVS 341 C AR + +P H + + + +++G++V +D + Y Sbjct: 116 HLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHG 175 Query: 342 DITRTWPVNGRFTAPQAELYEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLG- 400 D+ T+ V G +L + E + PG + ++LG Sbjct: 176 DLNETFFV-GEVDDGARKLVQTTYECLMQAIDAVKPGV---------------RYRELGN 219 Query: 401 IMKNIKENNAFKAARKYCPHHVGHYLGMDVHDTPDMPRSLP------LQPGMVITIEPGI 454 I++ + N F R YC GH + H P++P ++ G V TIEP I Sbjct: 220 IIQKHAQANGFSVVRSYC----GHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMI 275 >3ROR-A nrPDB Length = 291 Score = 35.4 bits (80), Expect = 0.052, Method: Compositional matrix adjust. Identities = 57/264 (21%), Positives = 102/264 (38%), Gaps = 41/264 (15%) Query: 246 IKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKFEFECRARGADILAYPPVVA 305 +++P IE+M++AG++ + A E + V + + D AYP + Sbjct: 47 VQTPEVIEKMRVAGRIAAGALAE----AGKAVAPGVTTDELDRIAHEYLVDNGAYPSTLG 102 Query: 306 --GGNRSNTL-------HYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGRFTAP 356 G +S + H + ++ +I DG++V +D D T+P G Sbjct: 103 YKGFPKSCSTSLNEVICHGIPDSTVITDGDIVNIDVTAYIGGVHGDTNATFPA-GDVADE 161 Query: 357 QAELYEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMKNIKENNAFKAARK 416 L + E + PG + L++IG+ ++++ + R Sbjct: 162 HRLLVDRTREATMRAINTVKPGRA--------LSVIGR------VIESYANRFGYNVVRD 207 Query: 417 YCPHHVGHYL--GMDV--HDTPDMPRSLPLQPGMVITIEPGIY-------IPEDDKDAPE 465 + H +G G+ V +D P + +QPGM TIEP I I +D Sbjct: 208 FTGHGIGTTFHNGLVVLHYDQPAV--ETIMQPGMTFTIEPMINLGALDYEIWDDGWTVVT 265 Query: 466 KFRGLGVRIEDDVVVTQDSPLILS 489 K R + E ++VT IL+ Sbjct: 266 KDRKWTAQFEHTLLVTDTGVEILT 289 >1CHM-A nrPDB Length = 401 Score = 35.0 bits (79), Expect = 0.086, Method: Compositional matrix adjust. Identities = 23/101 (22%), Positives = 47/101 (46%), Gaps = 14/101 (13%) Query: 360 LYEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMKNIKENNAFKAARKY-- 417 L++ +E+ L L PG +I ++L ++ + ++ + F + Sbjct: 276 LWQVNVEVHEAGLKLIKPGARCSDI--------ARELNEIFLKHDVLQYRTFGYGHSFGT 327 Query: 418 CPHHVGHYLGMDVHDTPDMPRSLPLQPGMVITIEPGIYIPE 458 H+ G G+++ + D L+PGMV+++EP I +PE Sbjct: 328 LSHYYGREAGLELREDIDTV----LEPGMVVSMEPMIMLPE 364 >4IU6-A nrPDB Length = 384 Score = 34.7 bits (78), Expect = 0.092, Method: Compositional matrix adjust. Identities = 48/240 (20%), Positives = 90/240 (37%), Gaps = 37/240 (15%) Query: 227 AKSKNKVRGVQQLIQRLRLIKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKF 286 ++S+ ++G Q+ +L+ S +IE M++ +L + K V + Sbjct: 116 SESEQALKGTSQI----KLLSS-EDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAV 170 Query: 287 EFECRARGA-----DILAYPPVVAGGNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYVS 341 C AR + +P H + + + +++G++V +D + Y Sbjct: 171 HLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHG 230 Query: 342 DITRTWPVNGRFTAPQAELYEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLG- 400 D+ T+ V G +L + E + PG + ++LG Sbjct: 231 DLNETFFV-GEVDDGARKLVQTTYECLMQAIDAVKPGV---------------RYRELGN 274 Query: 401 IMKNIKENNAFKAARKYCPHHVGHYLGMDVHDTPDMPRSLP------LQPGMVITIEPGI 454 I++ + N F R YC GH + H P++P ++ G V TIEP I Sbjct: 275 IIQKHAQANGFSVVRSYC----GHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMI 330 >2CDU-A nrPDB Length = 452 Score = 32.0 bits (71), Expect = 0.64, Method: Compositional matrix adjust. Identities = 17/54 (31%), Positives = 29/54 (53%), Gaps = 1/54 (1%) Query: 124 LCGFQEPDSILVLQSLPGKQLPSHKAILFVPRRDPSRELWDGPRSGTDGAIALT 177 + F+E D ++ ++L GK++ S AIL + R P+ EL G + D +T Sbjct: 214 VAAFEEVDDEIITKTLDGKEIKSDIAILCIGFR-PNTELLKGKVAMLDNGAIIT 266 >6CR2-A nrPDB Length = 477 Score = 31.6 bits (70), Expect = 0.76, Method: Compositional matrix adjust. Identities = 25/81 (30%), Positives = 35/81 (43%), Gaps = 12/81 (14%) Query: 285 KFEFECRARGADILAYPPVVAGGNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDIT 344 KF F+CRA+ DI + + G ++ K N I +G+ L C Y T Sbjct: 28 KFFFDCRAKYGDIFTF---ILLGKKTTVYLGTKGNDFILNGK---LRDVCAEEVYSPLTT 81 Query: 345 RTWPVNGR---FTAPQAELYE 362 PV GR + P A+L E Sbjct: 82 ---PVFGRHVVYDCPNAKLME 99 >3ZH9-B nrPDB Length = 347 Score = 29.6 bits (65), Expect = 3.5, Method: Compositional matrix adjust. Identities = 18/53 (33%), Positives = 27/53 (50%), Gaps = 1/53 (1%) Query: 45 YLGQPSPFTHPHLLRPGEVTPGLSQVEYALRRHKLMSLIQKEAQGQSGTDQTV 97 Y+ P+P+T LL P E ++ AL++H M + KE + TD TV Sbjct: 105 YIQSPAPYTVFVLLAPYEKLDERKKLTKALKKHAFM-MEAKELNAKETTDFTV 156 >5D08-A nrPDB Length = 437 Score = 29.3 bits (64), Expect = 3.7, Method: Compositional matrix adjust. Identities = 19/46 (41%), Positives = 26/46 (56%), Gaps = 3/46 (6%) Query: 123 YLCGFQEPDSILVLQSLPGKQLPSHKAILFVPRRDPSRELWDGPRS 168 YL GF+EPD + + P LP K+I+ + PSR + D PRS Sbjct: 73 YLSGFEEPD--IEKRVTPKLLLPKAKSIVAIALAYPSR-MKDAPRS 115 >6F8L-G nrPDB Length = 913 Score = 28.9 bits (63), Expect = 5.0, Method: Compositional matrix adjust. Identities = 18/44 (40%), Positives = 27/44 (61%), Gaps = 3/44 (6%) Query: 436 MPRSLPLQPGMVITIEPGIYIPEDDKDAPEKFRGLGVRIEDDVV 479 +PR+ PL I +E G+ PED ++A +K R G R+ED +V Sbjct: 330 LPRAKPLGE---ILVELGLARPEDVEEALQKQRRGGGRLEDTLV 370 >2P0M-A nrPDB Length = 662 Score = 28.5 bits (62), Expect = 6.5, Method: Compositional matrix adjust. Identities = 16/42 (38%), Positives = 18/42 (42%) Query: 333 GCESSCYVSDITRTWPVNGRFTAPQAELYEAVLEIQRDCLAL 374 G ESS Y D R W + R+ LY E RD L L Sbjct: 454 GVESSFYAQDALRLWEIISRYVQGIMGLYYKTDEAVRDDLEL 495 >5A8D-A nrPDB Length = 326 Score = 28.1 bits (61), Expect = 8.8, Method: Compositional matrix adjust. Identities = 45/175 (25%), Positives = 74/175 (42%), Gaps = 39/175 (22%) Query: 352 RFTA-PQAELYEAVLEIQRDCLALCFPGTSLENI--YSMMLTLIGQKLKDLGIMKNIKEN 408 RFTA P A +Y L I + PG S NI + + T + D G + N K + Sbjct: 35 RFTADPAAVVYNGRLYIYCSHDSDATPGQSTYNIPDITCISTDDLKNWTDHGEVFNAKRD 94 Query: 409 NAFKAARKYCPHHV----GHYLG---------MDVHDTPDMPRSLPLQPGMVIT------ 449 + + A+ + P V YL + V D+P P PL PG +++ Sbjct: 95 SRW-ASVSWAPSIVYRNNKFYLYYGNGGNGIGVAVSDSPTGPFKDPL-PGPLVSWNTPGV 152 Query: 450 --------IEPGIYIPEDDKDAPEKFRGLG------VRIEDDVVVTQDSPLILSA 490 +PG+++ +DD A F G G +++ +D++ T S + +SA Sbjct: 153 QPAQNMWLFDPGVFV-DDDGQAYMYFGGNGQNNIRVIKLGNDMISTVGSAMTMSA 206 >6MTD-E nrPDB Length = 291 Score = 28.1 bits (61), Expect = 9.2, Method: Compositional matrix adjust. Identities = 13/46 (28%), Positives = 26/46 (56%), Gaps = 1/46 (2%) Query: 68 SQVEYALRRHKLMSLIQKEAQG-QSGTDQTVVVLSNPTYYMSNDIP 112 S++E +R K+++ + K G ++G + V + P YY + D+P Sbjct: 80 SRIERKKKREKVLATVTKPVGGDKNGGTRVVKLRKMPRYYPTEDVP 125 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 5X49-A nrPDB 647 0.0 2BWY-A nrPDB 482 e-136 5WZE-A nrPDB 476 e-134 4PV4-A nrPDB 475 e-134 6A9U-A nrPDB 438 e-123 5MC5-A nrPDB 406 e-113 3IG4-A nrPDB 366 e-101 1WY2-A nrPDB 264 7e-71 1PV9-A nrPDB 262 2e-70 3Q6D-A nrPDB 255 2e-68 2ZSG-A nrPDB 254 6e-68 5CNX-A nrPDB 248 3e-66 3RVA-A nrPDB 244 7e-65 4ZNG-C nrPDB 244 8e-65 4RGZ-A nrPDB 235 4e-62 4QR8-A nrPDB 226 2e-59 4ZWP-A nrPDB 221 8e-58 3L7G-A nrPDB 220 1e-57 4A6V-A nrPDB 216 1e-56 5CE6-A nrPDB 208 3e-54 4FO7-A nrPDB 208 4e-54 4KM3-A nrPDB 198 6e-51 6MRF-A nrPDB 194 6e-50 1O0X-A nrPDB 183 1e-46 3TB5-A nrPDB 181 5e-46 1QXW-A nrPDB 169 3e-42 3CTZ-A nrPDB 165 3e-41 4S2R-P nrPDB 148 8e-36 Sequences not found previously or not previously below threshold: 3MR1-A nrPDB 169 4e-42 3ROR-A nrPDB 163 3e-40 4IU6-A nrPDB 158 4e-39 2B3K-A nrPDB 157 1e-38 3S6B-A nrPDB 144 1e-34 4FUK-A nrPDB 143 3e-34 3TAV-A nrPDB 137 1e-32 5JR6-A nrPDB 134 1e-31 5E5B-A nrPDB 107 1e-23 1CHM-A nrPDB 99 4e-21 3CB5-A nrPDB 98 7e-21 1XGN-A nrPDB 82 5e-16 6A8M-A nrPDB 81 1e-15 4B28-A nrPDB 78 7e-15 3BIQ-A nrPDB 70 2e-12 5LYW-A nrPDB 66 4e-11 1QZY-A nrPDB 66 5e-11 2Q8K-A nrPDB 57 2e-08 2V6C-A nrPDB 57 2e-08 3FMR-A nrPDB 41 0.002 1VHV-A nrPDB 32 0.46 1CHD-A nrPDB 32 0.77 1A2O-A nrPDB 32 0.88 5YLZ-V nrPDB 31 1.0 6F8L-G nrPDB 31 1.6 2DW2-A nrPDB 31 1.7 1V0D-A nrPDB 30 2.5 5APN-x nrPDB 30 3.0 5FPN-A nrPDB 29 4.9 2QR4-A nrPDB 29 5.1 >5X49-A nrPDB Length = 456 Score = 647 bits (1668), Expect = 0.0, Method: Composition-based stats. Identities = 454/455 (99%), Positives = 455/455 (100%) Query: 53 THPHLLRPGEVTPGLSQVEYALRRHKLMSLIQKEAQGQSGTDQTVVVLSNPTYYMSNDIP 112 +HPHLLRPGEVTPGLSQVEYALRRHKLMSLIQKEAQGQSGTDQTVVVLSNPTYYMSNDIP Sbjct: 2 SHPHLLRPGEVTPGLSQVEYALRRHKLMSLIQKEAQGQSGTDQTVVVLSNPTYYMSNDIP 61 Query: 113 YTFHQDNNFLYLCGFQEPDSILVLQSLPGKQLPSHKAILFVPRRDPSRELWDGPRSGTDG 172 YTFHQDNNFLYLCGFQEPDSILVLQSLPGKQLPSHKAILFVPRRDPSRELWDGPRSGTDG Sbjct: 62 YTFHQDNNFLYLCGFQEPDSILVLQSLPGKQLPSHKAILFVPRRDPSRELWDGPRSGTDG 121 Query: 173 AIALTGVDEAYTLEEFQHLLPKMKAETNMVWYDWMRPSHAQLHSDYMQPLTEAKAKSKNK 232 AIALTGVDEAYTLEEFQHLLPKMKAETNMVWYDWMRPSHAQLHSDYMQPLTEAKAKSKNK Sbjct: 122 AIALTGVDEAYTLEEFQHLLPKMKAETNMVWYDWMRPSHAQLHSDYMQPLTEAKAKSKNK 181 Query: 233 VRGVQQLIQRLRLIKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKFEFECRA 292 VRGVQQLIQRLRLIKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKFEFECRA Sbjct: 182 VRGVQQLIQRLRLIKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKFEFECRA 241 Query: 293 RGADILAYPPVVAGGNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGR 352 RGADILAYPPVVAGGNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGR Sbjct: 242 RGADILAYPPVVAGGNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGR 301 Query: 353 FTAPQAELYEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMKNIKENNAFK 412 FTAPQAELYEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMKNIKENNAFK Sbjct: 302 FTAPQAELYEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMKNIKENNAFK 361 Query: 413 AARKYCPHHVGHYLGMDVHDTPDMPRSLPLQPGMVITIEPGIYIPEDDKDAPEKFRGLGV 472 AARKYCPHHVGHYLGMDVHDTPDMPRSLPLQPGMVITIEPGIYIPEDDKDAPEKFRGLGV Sbjct: 362 AARKYCPHHVGHYLGMDVHDTPDMPRSLPLQPGMVITIEPGIYIPEDDKDAPEKFRGLGV 421 Query: 473 RIEDDVVVTQDSPLILSADCPKEMNDIEQICSQAS 507 RIEDDVVVTQDSPLILSADCPKEMNDIEQICSQAS Sbjct: 422 RIEDDVVVTQDSPLILSADCPKEMNDIEQICSQAS 456 >2BWY-A nrPDB Length = 440 Score = 482 bits (1240), Expect = e-136, Method: Composition-based stats. Identities = 146/449 (32%), Positives = 230/449 (51%), Gaps = 23/449 (5%) Query: 67 LSQVEYALRRHKLMSLIQKEAQGQSGTDQTVVVLSNPTYYMSNDIPYTFHQDNNFLYLCG 126 +S+ E+ RR L+ Q ++ + P S D Y + Q+++F Y G Sbjct: 3 ISRQEFQRRRQALVE--------QMQPGSAALIFAAPEVTRSADSEYPYRQNSDFWYFTG 54 Query: 127 FQEPDSILVLQSLPGKQLPSHKAILFVPRRDPSRELWDGPRSGTDGAIALTGVDEAYTLE 186 F EP+++LVL + +H ++LF RD + E+W G R G D A GVD A Sbjct: 55 FNEPEAVLVL--IKSDDTHNH-SVLFNRVRDLTAEIWFGRRLGQDAAPEKLGVDRALAFS 111 Query: 187 EFQHLLPKMKAETNMVWYDWMRPSHAQLHSDYMQPLTEAKAKSKNKVRGVQ------QLI 240 E L ++ ++V++ + +A L + + S+ + ++ Sbjct: 112 EINQQLYQLLNGLDVVYH--AQGEYAYADVIVNSALEKLRKGSRQNLTAPATMIDWRPVV 169 Query: 241 QRLRLIKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKFEFECRARGADILAY 300 +RL KSP EI ++ AG++T+ A M + + E L + E GA +Y Sbjct: 170 HEMRLFKSPEEIAVLRRAGEITAMAHTRAMEKCRPGMFEYHLEGEIHHEFNRHGARYPSY 229 Query: 301 PPVVAGGNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGRFTAPQAEL 360 +V G LHY +N ++DG++VL+D GCE Y DITRT+PVNG+FT Q E+ Sbjct: 230 NTIVGSGENGCILHYTENECEMRDGDLVLIDAGCEYKGYAGDITRTFPVNGKFTQAQREI 289 Query: 361 YEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMK-NIKENNAFKAARKYCP 419 Y+ VLE L L PGTS+ + ++ ++ L LGI+K ++ E A A R + Sbjct: 290 YDIVLESLETSLRLYRPGTSILEVTGEVVRIMVSGLVKLGILKGDVDELIAQNAHRPFFM 349 Query: 420 HHVGHYLGMDVHDTPDMP--RSLPLQPGMVITIEPGIYIPEDDKDAPEKFRGLGVRIEDD 477 H + H+LG+DVHD RS L+PGMV+T+ PG+YI D + PE++RG+G+RIEDD Sbjct: 350 HGLSHWLGLDVHDVGVYGQDRSRILEPGMVLTVAPGLYIAPD-AEVPEQYRGIGIRIEDD 408 Query: 478 VVVTQDSPLILSADCPKEMNDIEQICSQA 506 +V+T+ L+A K+ +IE + A Sbjct: 409 IVITETGNENLTASVVKKPEEIEALMVAA 437 >5WZE-A nrPDB Length = 452 Score = 476 bits (1225), Expect = e-134, Method: Composition-based stats. Identities = 158/448 (35%), Positives = 248/448 (55%), Gaps = 20/448 (4%) Query: 67 LSQVEYALRRHKLMSLIQKEAQGQSGTDQTVVVLSNPTYYMSNDIPYTFHQDNNFLYLCG 126 + + EYA RR LM+ Q + ++ + P Y + D+ + + QD++F YL G Sbjct: 4 IPKSEYARRRKALMA--------QMEPNSIAILPAAPMYIRNRDVEHVYRQDSDFQYLTG 55 Query: 127 FQEPDSILVLQSLPGKQLPSHKAILFVPRRDPSRELWDGPRSGTDGAIALTGVDEAYTLE 186 F EP++++ L +PG+ + +LF RDP RELWDG R+G DGAI G D+A+ + Sbjct: 56 FPEPEAVMAL--IPGRAHGEY--VLFCRERDPERELWDGLRAGQDGAIGQYGADDAFPIG 111 Query: 187 EFQHLLPKMKAETNMVWYDW-MRPSHAQLHSDYMQPLTEAK---AKSKNKVRGVQQLIQR 242 + +LP + + V+Y P + D++ + A+ N+ + L+ Sbjct: 112 DIDDILPGLIEGRDRVYYALGANPDFDRRLMDWINVIRSKARQGAQPPNEFVALDHLLHD 171 Query: 243 LRLIKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKFEFECRARGADILAYPP 302 RL KS E++ M+ A +++++A I M + + E L A+ E+E R GA + AY Sbjct: 172 QRLYKSANEVKVMRYAAEVSARAHIRAMEVCRPGLFEYHLEAELEYEFRKGGAKMPAYGS 231 Query: 303 VVAGGNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGRFTAPQAELYE 362 +VA G + LHY +N+ IKDG+++L+D GCE CY SDITRT+P NGRF+ Q +YE Sbjct: 232 IVAAGRNACILHYRENDAAIKDGDLILIDAGCEIDCYASDITRTFPANGRFSPEQKAIYE 291 Query: 363 AVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMK-NIKENNAFKAARKYCPHH 421 VLE PG + + +I L LG+++ ++ E A +A + + H Sbjct: 292 LVLEANMAAFDYIAPGRHWNEAHEATVRVITAGLVRLGLLEGDVDELIAHEAYKAFYMHR 351 Query: 422 VGHYLGMDVHDTPDM---PRSLPLQPGMVITIEPGIYIPEDDKDAPEKFRGLGVRIEDDV 478 GH+LGMDVHD + L+PGM +T+EPGIYI D+ +K+RG+GVRIEDDV Sbjct: 352 AGHWLGMDVHDVGEYRVGGEWRVLEPGMAMTVEPGIYIAPDNTTVAKKWRGIGVRIEDDV 411 Query: 479 VVTQDSPLILSADCPKEMNDIEQICSQA 506 VVT++ +L+ PK + +IE + + A Sbjct: 412 VVTRNGCEVLTNGVPKTVAEIEALMAAA 439 >4PV4-A nrPDB Length = 445 Score = 475 bits (1222), Expect = e-134, Method: Composition-based stats. Identities = 143/448 (31%), Positives = 233/448 (52%), Gaps = 24/448 (5%) Query: 67 LSQVEYALRRHKLMSLIQKEAQGQSGTDQTVVVLSNPTYYMSNDIPYTFHQDNNFLYLCG 126 ++Q EY RR L++ + ++ + P S D Y + Q+++F YL G Sbjct: 1 MTQQEYQNRRQALLA--------KMAPGSAAIIFAAPEATRSADSEYPYRQNSDFSYLTG 52 Query: 127 FQEPDSILVLQSLPGKQLPSHKAILFVPRRDPSRELWDGPRSGTDGAIALTGVDEAYTLE 186 F EP+++L+L + + +H ++LF RD + E+W G R G + A VD A + Sbjct: 53 FNEPEAVLIL--VKSDETHNH-SVLFNRIRDLTAEIWFGRRLGQEAAPTKLAVDRALPFD 109 Query: 187 EFQHLLPKMKAETNMVWYDWMRPSHAQLHSDYMQPLTEAKAKSKNKVRGVQ------QLI 240 E L + +++++ + +A + L + + + +R + Sbjct: 110 EINEQLYLLLNRLDVIYH--AQGQYAYADNIVFAALEKLRHGFRKNLRAPATLTDWRPWL 167 Query: 241 QRLRLIKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKFEFECRARGADILAY 300 +RL KS EI ++ AG++++ A M + + E L + E GA AY Sbjct: 168 HEMRLFKSAEEIAVLRRAGEISALAHTRAMEKCRPGMFEYQLEGEILHEFTRHGARYPAY 227 Query: 301 PPVVAGGNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGRFTAPQAEL 360 +V GG LHY +N ++DG++VL+D GCE Y DITRT+PVNG+FT Q + Sbjct: 228 NTIVGGGENGCILHYTENECELRDGDLVLIDAGCEYRGYAGDITRTFPVNGKFTPAQRAV 287 Query: 361 YEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMK-NIKENNAFKAARKYCP 419 Y+ VL L L PGTS+ + ++ ++ L +LGI+K +I++ A +A R + Sbjct: 288 YDIVLAAINKSLTLFRPGTSIREVTEEVVRIMVVGLVELGILKGDIEQLIAEQAHRPFFM 347 Query: 420 HHVGHYLGMDVHDTPDMP---RSLPLQPGMVITIEPGIYIPEDDKDAPEKFRGLGVRIED 476 H + H+LGMDVHD D R L+PGMV+T+EPG+YI D D P ++RG+G+RIED Sbjct: 348 HGLSHWLGMDVHDVGDYGSSDRGRILEPGMVLTVEPGLYIAPD-ADVPPQYRGIGIRIED 406 Query: 477 DVVVTQDSPLILSADCPKEMNDIEQICS 504 D+V+T L+A K+ +DIE + + Sbjct: 407 DIVITATGNENLTASVVKDPDDIEALMA 434 >6A9U-A nrPDB Length = 455 Score = 438 bits (1127), Expect = e-123, Method: Composition-based stats. Identities = 156/454 (34%), Positives = 253/454 (55%), Gaps = 28/454 (6%) Query: 61 GEVTPGLSQVEYALRRHKLMSLIQKEAQGQSGTDQTVVVLSNPTYYMSNDIPYTFHQDNN 120 GE+TPG+S +EY RR +L + ++ V++ N + S + Y F Q+N+ Sbjct: 3 GELTPGISALEYYERRIRLAETLPPKS--------CVILAGNDIQFASGAVFYPFQQEND 54 Query: 121 FLYLCGFQEPDSILVLQSLPGKQLPSHKAILFVPRRDPSRELWDGPRSGTDGAIALTGVD 180 YL G+ EP+S+++L+ P L + VP +D E W+G RSG G + D Sbjct: 55 LFYLSGWNEPNSVMILEK-PTDSLSDTIFHMLVPPKDAFAEKWEGFRSGVYGVQEIFNAD 113 Query: 181 EAYTLEEFQHLLPKMKAETNMVWYDWMRPSH-AQLHSDYMQPLTEAKAKSKN-------- 231 E+ ++ + LPK+ +++D + S+ + + +++ L + S Sbjct: 114 ESASINDLSKYLPKIINRNEFIYFDMLSTSNPSSSNFKHIKSLLDGSGNSNRSLNSIANK 173 Query: 232 KVRGVQQLIQRLRLIKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKFEFECR 291 ++ + + I R IKSP E+ M+ AG+++ ++F + +K E L + ++ Sbjct: 174 TIKPISKRIAEFRKIKSPQELRIMRRAGQISGRSFNQAF--AKRFRNERTLDSFLHYKFI 231 Query: 292 ARGADILAYPPVVAGGNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNG 351 + G D AY PVVA G+ S +HY +N+ ++ D EMVL+D Y +DI+RTWP +G Sbjct: 232 SGGCDKDAYIPVVATGSNSLCIHYTRNDDVMFDDEMVLVDAAGSLGGYCADISRTWPNSG 291 Query: 352 RFTAPQAELYEAVLEIQRDCLALCFPGT--SLENIYSMMLTLIGQKLKDLGIMKNIKENN 409 +FT Q +LYEAVL +QRDC+ LC SL +I+ +TL+ Q+LK+LGI K N Sbjct: 292 KFTDAQRDLYEAVLNVQRDCIKLCKASNNYSLHDIHEKSITLMKQELKNLGIDKVSGWN- 350 Query: 410 AFKAARKYCPHHVGHYLGMDVHDTPDMPRSLPLQPGMVITIEPGIYIPEDDKDAPEKFRG 469 K PH++GH LG+DVHD P + R PL+ G VITIEPG+YIP +++ P FR Sbjct: 351 ----VEKLYPHYIGHNLGLDVHDVPKVSRYEPLKVGQVITIEPGLYIP-NEESFPSYFRN 405 Query: 470 LGVRIEDDVVVTQDSPLILSADCPKEMNDIEQIC 503 +G+RIEDD+ + +D+ L+ + KE++D+E + Sbjct: 406 VGIRIEDDIAIGEDTYTNLTVEAVKEIDDLENVM 439 >5MC5-A nrPDB Length = 478 Score = 406 bits (1042), Expect = e-113, Method: Composition-based stats. Identities = 130/470 (27%), Positives = 209/470 (44%), Gaps = 50/470 (10%) Query: 72 YALRRHKLMSLIQKEAQGQSGTDQTVVVLSNPTYYMSNDIPYTFHQDNNFLYLCGFQEPD 131 +AL R +L ++K Q+G+ V+ T D F Q++ F + G EP Sbjct: 18 FALNRQRLCERLRKNPAVQAGS-IVVLQGGEETQRYCTDTGVLFRQESFFHWAFGVTEPG 76 Query: 132 SILVLQSLPGKQLPSHKAILFVPRRDPSRELWDGPRSGTDGAIALTGVDEAYTLEEFQHL 191 V+ G K+ LFVPR S W G + VD+ ++E + Sbjct: 77 CYGVIDVDTG------KSTLFVPRLPASHATWMGKIHSKEHFKEKYAVDDVQYVDEIASV 130 Query: 192 LPKMKAETNMVWYDWMRPSHAQLHSDYMQPLTEAKAKSKNKVRGVQQLIQRLRLIKSPAE 251 L K + +R + S + + +K + + I R+ K+ E Sbjct: 131 LTSQKPSVLLT----LRGVNTDSGSVCREASFDGISKFEVNNTILHPEIVECRVFKTDME 186 Query: 252 IERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKFEFECRARGA-DILAYPPVVAGGNRS 310 +E ++ K++S+A E M K ++E L + FE C +RG +Y + G S Sbjct: 187 LEVLRYTNKISSEAHREVMKAVKVGMKEYELESLFEHYCYSRGGMRHSSYTCICGSGENS 246 Query: 311 NTLHY----VKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGRFTAPQAELYEAVLE 366 LHY N++ I++G+M L D G E C+ SDIT ++P NG+FTA Q +YEAVL Sbjct: 247 AVLHYGHAGAPNDRTIQNGDMCLFDMGGEYYCFASDITCSFPANGKFTADQKAVYEAVLR 306 Query: 367 IQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMK-NIKENNAFKAARKYCPHHVGHY 425 R + PG +++ + + ++L +GI+ ++ + PH +GH+ Sbjct: 307 SSRAVMGAMKPGVWWPDMHRLADRIHLEELAHMGILSGSVDAMVQAHLGAVFMPHGLGHF 366 Query: 426 LGMDVHDTPDMPRS---------------LPLQPGMVITIEPGIYIPED----------- 459 LG+DVHD P LQPGMV+T+EPGIY + Sbjct: 367 LGIDVHDVGGYPEGVERIDEPGLRSLRTARHLQPGMVLTVEPGIYFIDHLLDEALADPAR 426 Query: 460 ----DKDAPEKFRGL-GVRIEDDVVVTQDSPLILSADCPKEMNDIEQICS 504 +++ ++FRG GVRIED VVVT +L+ P+ + +IE + Sbjct: 427 ASFLNREVLQRFRGFGGVRIED-VVVTDSGIELLT-CVPRTVEEIEACMA 474 >3IG4-A nrPDB Length = 427 Score = 366 bits (938), Expect = e-101, Method: Composition-based stats. Identities = 119/429 (27%), Positives = 209/429 (48%), Gaps = 43/429 (10%) Query: 72 YALRRHKLMSLIQKEAQGQSGTDQTVVVLSNPTYYMSNDIPYTFHQDNNFLYLCGFQEPD 131 +A R +L++ + E+ ++ + +MS D Y F + NF Y+ G EP+ Sbjct: 6 FAQNRERLVNTLPDES--------ITILFAGQAPHMSADAHYKFVPNRNFYYVTGIDEPN 57 Query: 132 SILVLQSLPGKQLPSHKAILFVPRRDPSRELWDGPRSGTDGAIALTGVDEAYTLEEFQHL 191 I +L+ S + LF+ + DP E W G + A ++G+ + L+ F+ Sbjct: 58 VIFMLKKFGN----SVEETLFIEKSDPVMEKWVGKTVSNEEAEKISGIKKVIYLDSFE-- 111 Query: 192 LPKMKAETNMVWYDWMRPSHAQLH-SDYMQPLTEAKAKSKN--------KVRGVQQLIQR 242 K +N+ + + ++ + L ++ T+ A +K+ + V I Sbjct: 112 ----KTMSNIFFTENVKHLYLDLECREWKGTETKTLAFAKHVREQYPHVTIGNVYPNICE 167 Query: 243 LRLIKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKFEFECRARGADILAYPP 302 LR+ K+ EIE ++ A +T + +KA + E L A+F+F ++ G A+ Sbjct: 168 LRVFKTDEEIEIIKEAIAVTKDGIYNVLKHAKADMMEYELEAQFDFTLKSSGIKHHAFNT 227 Query: 303 VVAGGNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGRFTAPQAELYE 362 ++A G + LHY N+ I++G++VLLD G + Y +DI+ T+P NG F++ Q ++Y Sbjct: 228 ILASGKNATVLHYEDNDAQIQNGDLVLLDLGAQKDYYNADISYTFPANGTFSSRQKQIYN 287 Query: 363 AVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMKNIKENNAFKAARKYCPHHV 422 VL ++ + PG + ++ + K +G+++ +E KY H V Sbjct: 288 IVLNALKETTEIIKPGLKFAALNEHAKKVLAEGCKAVGLIQEDEEL------SKYYYHGV 341 Query: 423 GHYLGMDVHDTPDMPRSLPLQPGMVITIEPGIYIPEDDKDAPEKFRGLGVRIEDDVVVTQ 482 H+LG+D HD + L+ GMVITIEPG+YI E+ +G+RIEDD++VT+ Sbjct: 342 SHFLGLDTHDVGTY-KDRVLEEGMVITIEPGLYIEEE---------SIGIRIEDDILVTK 391 Query: 483 DSPLILSAD 491 D LS D Sbjct: 392 DGHENLSKD 400 >1WY2-A nrPDB Length = 351 Score = 264 bits (674), Expect = 7e-71, Method: Composition-based stats. Identities = 83/272 (30%), Positives = 138/272 (50%), Gaps = 31/272 (11%) Query: 222 LTEAKAKSKNK-VRGVQQLIQRLRLIKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEA 280 + E K K+ K + V +I+ +R+IKS EI+ ++ A ++ +A + + +E Sbjct: 102 IEELKKKANIKEFKKVDDVIRDMRIIKSEKEIKIIEKACEIADKAVMAAIEEITEGKKER 161 Query: 281 FLYAKFEFECRARGADILAYPPVVAGGNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYV 340 + AK E+ + GA+ A+ ++A G RS H V +++ I+ G++V++D G Y Sbjct: 162 EVAAKVEYLMKMNGAEKPAFDTIIASGYRSALPHGVASDKRIERGDLVVIDLGALYQHYN 221 Query: 341 SDITRTWPVNGRFTAPQAELYEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLG 400 SDITRT V G Q E+YE VLE Q+ + PG + + + S+ +I + Sbjct: 222 SDITRTIVV-GSPNEKQKEIYEIVLEAQKKAVESAKPGITAKELDSIARNIIAE------ 274 Query: 401 IMKNIKENNAFKAARKYCPHHVGHYLGMDVHDTPDMP--RSLPLQPGMVITIEPGIYIPE 458 +Y H +GH +G++VH+ P + L+ GMVITIEPGIYIP+ Sbjct: 275 -----------YGYGEYFNHSLGHGVGLEVHEWPRVSQYDETVLREGMVITIEPGIYIPK 323 Query: 459 DDKDAPEKFRGLGVRIEDDVVVTQDSPLILSA 490 GVRIED +++T++ L+ Sbjct: 324 IG----------GVRIEDTILITKNGSKRLTK 345 >1PV9-A nrPDB Length = 348 Score = 262 bits (669), Expect = 2e-70, Method: Composition-based stats. Identities = 83/272 (30%), Positives = 137/272 (50%), Gaps = 31/272 (11%) Query: 222 LTEAKAKSKNK-VRGVQQLIQRLRLIKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEA 280 + K KS K + + +I+ LR+IK+ EIE ++ A ++ +A + + E Sbjct: 99 VENFKEKSNVKEFKKIDDVIKDLRIIKTKEEIEIIEKACEIADKAVMAAIEEITEGKRER 158 Query: 281 FLYAKFEFECRARGADILAYPPVVAGGNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYV 340 + AK E+ + GA+ A+ ++A G+RS H V +++ I+ G++V++D G + Y Sbjct: 159 EVAAKVEYLMKMNGAEKPAFDTIIASGHRSALPHGVASDKRIERGDLVVIDLGALYNHYN 218 Query: 341 SDITRTWPVNGRFTAPQAELYEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLG 400 SDITRT V G Q E+YE VLE Q+ + PG + + + S+ +I + Sbjct: 219 SDITRTIVV-GSPNEKQREIYEIVLEAQKRAVEAAKPGMTAKELDSIAREIIKE------ 271 Query: 401 IMKNIKENNAFKAARKYCPHHVGHYLGMDVHDTPDMP--RSLPLQPGMVITIEPGIYIPE 458 Y H +GH +G+++H+ P + L+ GMVITIEPGIYIP+ Sbjct: 272 -----------YGYGDYFIHSLGHGVGLEIHEWPRISQYDETVLKEGMVITIEPGIYIPK 320 Query: 459 DDKDAPEKFRGLGVRIEDDVVVTQDSPLILSA 490 GVRIED V++T++ L+ Sbjct: 321 LG----------GVRIEDTVLITENGAKRLTK 342 >3Q6D-A nrPDB Length = 356 Score = 255 bits (652), Expect = 2e-68, Method: Composition-based stats. Identities = 84/314 (26%), Positives = 140/314 (44%), Gaps = 41/314 (13%) Query: 185 LEEFQHLLPKMKAETNMVWYDWMRPSHAQLHSDYMQPLTEAKAKSKNKVRGVQQLIQRLR 244 ++E + ++ + D + S H + + + L+++LR Sbjct: 79 IDEVAKQVKELGIQKLGFEQDTLTYSSYSAHKEAIDA----------EFIPTSGLVEKLR 128 Query: 245 LIKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKFEFECRARGADILAYPPVV 304 LIK+ +EI+ ++ A ++ AF + + V E + + EF R +GA ++ +V Sbjct: 129 LIKTDSEIKILKEAAQIADAAFEHILSFIRPGVSEIEVSNELEFFMRKQGATSSSFDIIV 188 Query: 305 AGGNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGRFTAPQAELYEAV 364 A G RS H V + ++I+ G+ V LD G Y SDITRT V G + E+Y V Sbjct: 189 ASGLRSALPHGVASEKVIETGDFVTLDFGAYYKGYCSDITRTIAV-GEPSDKLKEIYNIV 247 Query: 365 LEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMKNIKENNAFKAARKYCPHHVGH 424 LE Q + G + ++ I + K +Y H GH Sbjct: 248 LEAQLRGVNGIKAGLTGREADALTRDYITE-----------------KGYGEYFGHSTGH 290 Query: 425 YLGMDVHDTPD--MPRSLPLQPGMVITIEPGIYIPEDDKDAPEKFRGLGVRIEDDVVVTQ 482 +G+++H+ P L+PGM +T+EPGIYIP GVRIEDD++VT Sbjct: 291 GIGLEIHEAPGLAFRSDTVLEPGMAVTVEPGIYIPGIG----------GVRIEDDIIVTS 340 Query: 483 DSPLILSADCPKEM 496 + +++ PKE+ Sbjct: 341 EGNEVIT-KSPKEL 353 >2ZSG-A nrPDB Length = 359 Score = 254 bits (649), Expect = 6e-68, Method: Composition-based stats. Identities = 72/274 (26%), Positives = 137/274 (50%), Gaps = 31/274 (11%) Query: 225 AKAKSKNKVRGVQQLIQRLRLIKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFLYA 284 + A K G+ ++++R++K EIE+++ A +++ +AF+ET+ +A + E + A Sbjct: 112 SSAFGDRKFIGIDDEVKQMRMVKDEGEIEKIKQAIEISERAFLETVQQIRAGMTEKEIAA 171 Query: 285 KFEFECRARGADILAYPPVVAGGNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDIT 344 E+ R GA+ +A+ +VA G RS H ++++++ G+++++D G Y +DIT Sbjct: 172 LLEYTMRKEGAEGVAFDTIVASGCRSALPHGKASDKVVERGDVIVIDFGATYENYCADIT 231 Query: 345 RTWPVNGRFTAPQAELYEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMKN 404 R + G + E++ VLE Q L + G + + + S+ I + Sbjct: 232 RVVSI-GEPSDEVKEVHSIVLEAQERALKIAKAGVTGKLLDSVAREFIRE---------- 280 Query: 405 IKENNAFKAARKYCPHHVGHYLGMDVHDTPDMP--RSLPLQPGMVITIEPGIYIPEDDKD 462 K ++ H +GH +G++VH+ P + PL +V T+EPGIY+ Sbjct: 281 -------KGYGEFFGHSLGHGIGLEVHEGPAISFRNDSPLPENVVFTVEPGIYLEG---- 329 Query: 463 APEKFRGLGVRIEDDVVVTQDSPLILSADCPKEM 496 G+RIE+DVV+ + IL+ P+ + Sbjct: 330 ------KFGIRIEEDVVLKEQGCEILTT-LPRSI 356 >5CNX-A nrPDB Length = 361 Score = 248 bits (634), Expect = 3e-66, Method: Composition-based stats. Identities = 76/260 (29%), Positives = 124/260 (47%), Gaps = 34/260 (13%) Query: 243 LRLIKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKFEFECRARGADILAYPP 302 LR IK+P E+E++++A + + +A + E + A+ E+ R +GA+ ++ Sbjct: 124 LRQIKTPEEVEKIRLACGIADRGAEHIRRFIQAGMSEREIAAELEWFMRQQGAEKASFDT 183 Query: 303 VVAGGNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGRFTAPQAEL-- 360 +VA G R H +++++ GE V LD G Y SD+TRT VNG + ++ L Sbjct: 184 IVASGWRGALPHGKASDKIVAAGEFVTLDFGALYQGYCSDMTRTLLVNGEGVSAESHLLF 243 Query: 361 --YEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMKNIKENNAFKAARKYC 418 Y+ VL+ Q ++ PG + + +I + Y Sbjct: 244 NVYQIVLQAQLAAISAIRPGVRCQQVDDAARRVITE-----------------AGYGDYF 286 Query: 419 PHHVGHYLGMDVHDTPDMP--RSLPLQPGMVITIEPGIYIPEDDKDAPEKFRGLGVRIED 476 H+ GH +G++VH+ P + LQPGM++T+EPGIY+P GVRIED Sbjct: 287 GHNTGHAIGIEVHEDPRFSPRDTTTLQPGMLLTVEPGIYLPGQG----------GVRIED 336 Query: 477 DVVVTQDSPLILSADCPKEM 496 V+VT +L A PK + Sbjct: 337 VVLVTPQGAEVLYA-MPKTV 355 >3RVA-A nrPDB Length = 451 Score = 244 bits (622), Expect = 7e-65, Method: Composition-based stats. Identities = 97/464 (20%), Positives = 176/464 (37%), Gaps = 76/464 (16%) Query: 72 YALRRHKLMSLIQKEAQGQSGTDQTVVVLSNPTYYMSNDIPYTFHQDNNF-LYLCGFQEP 130 Y +L + + EA + G D V+ +D Y F + F ++ P Sbjct: 8 YQQHIEELQARTR-EALQREGLDGLVIHSGQGKRLFLDDNHYPFKVNPQFKAWVPVIDNP 66 Query: 131 DSILVLQSLPGKQLPSHKAILFVPRRDPSRELWDGPRSGTDGAIALTGVDEAYTLEEFQH 190 + LV+ + ++F D ++ P D + + + Sbjct: 67 NCWLVVNGV------DKPTLIFYRPEDFWHKV---PPEPNDFWTDSFDIKLLQQADAVEK 117 Query: 191 LLPKMKAETNMVWYDWMRPSHAQLHSDYMQPLTEAKAKSKNKVRGVQQLIQRLRLIKSPA 250 LP YD R ++ +Y++ +A V + R K+ Sbjct: 118 FLP----------YDKSRFAYV---GEYIEV-AKALGFDNVNPDRVLHYLHYQRAYKTDY 163 Query: 251 EIERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKFEFECR-------ARGADILAYPPV 303 E++ M+ A KL E+AF K EF+ +G + + Y + Sbjct: 164 ELDCMREANKLA--------VAGHKAAEQAFREGKSEFDINLAYAAASRQGDNDVPYTSI 215 Query: 304 VAGGNRSNTLHYVKNNQLI-KDGEMVLLDGGCESSCYVSDITRTWPVNG-RFTAPQAELY 361 VA ++ LHY++ + + K+ L+D G Y +DITRT+ G +A +L Sbjct: 216 VALNEHASILHYMQCDTVAPKESRSFLIDAGANYHGYAADITRTYAQEGVHNSAMFRDLI 275 Query: 362 EAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMK-NIKENNAFKAARKYCPH 420 +AV ++ + PG + +I+ + I Q L D G++ E R + PH Sbjct: 276 QAVDKVTLTLVDSLKPGVAYTDIHLLAHDGIAQILHDTGMVNLTPPEIVEMGITRTFFPH 335 Query: 421 HVGHYLGMDVHDT------------------PDMPRSLPLQPGMVITIEPGIYIPED--- 459 +GH+LG+ VHD P + + ++ V TIEPG+Y + Sbjct: 336 GIGHFLGLQVHDVGGLVNDDRGTPKPAPDDHPFLRCTRMVEARQVFTIEPGLYFIDSLLR 395 Query: 460 -----------DKDAPEKFRGL-GVRIEDDVVVTQDSPLILSAD 491 + D + ++ G+RIED+++V +D ++ D Sbjct: 396 DLKATPASKYINWDTIDAYKPFGGIRIEDNIIVHRDKNENMTRD 439 >4ZNG-C nrPDB Length = 362 Score = 244 bits (622), Expect = 8e-65, Method: Composition-based stats. Identities = 89/370 (24%), Positives = 150/370 (40%), Gaps = 38/370 (10%) Query: 124 LCGFQEPDSILVLQSLPGKQLPSHKAILFVPRRDPSRELWDGPRSGTDGAIALTGVDEAY 183 + P ++ L L ++ P + P + A T + + Sbjct: 18 MTFITNPTTLNYLTGLAIDPHERIAGLMIFRDSTP---MLFTPALEVEKAKEHTSGLDIF 74 Query: 184 TLEEFQHLLPKMKAETNMVWYDWMRPSHAQLHSDYMQPLTEAKAKSKNKVRGVQQLIQRL 243 E+ Q+ +K D + + + LI+R+ Sbjct: 75 GYEDSQNPWEVVKNHVKS---DVKSIAVEFSDIPLAKTEGLKAQFGDINFVNLTPLIERM 131 Query: 244 RLIKSPAEIERMQIAGKLTSQAFIETMFTS--KAPVEEAFLYAKFEFECRARGADILAYP 301 RLIKS EIE+M++AG + F T+ + V E+ + AK E+E + G +++ Sbjct: 132 RLIKSADEIEKMKVAGDFADKCFEIGFATAAERNGVTESDIVAKIEYEMKRMGVPQMSFD 191 Query: 302 PVVAGGNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGRFTAPQAELY 361 +V G R+ H N I++ +++L D G S Y SD TRT + G+ AE++ Sbjct: 192 TLVLSGARAANPHGAPENVEIQENKLLLFDLGVMSGGYASDATRTIAI-GQPNDFDAEIH 250 Query: 362 EAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMKNIKENNAFKAARKYCPHH 421 + V E Q+ + PG + + ++ LI + +Y H Sbjct: 251 KIVKEAQQAAMDFIKPGVTAHEVDAVARDLITK-----------------AGYGEYFNHR 293 Query: 422 VGHYLGMDVHDTPDM--PRSLPLQPGMVITIEPGIYIPEDDKDAPEKFRGLGVRIEDDVV 479 +GH +GMDVH+ P + L +Q GM + EPGIYIP +GVRIED + Sbjct: 294 LGHGIGMDVHEYPSIVAGNDLVIQEGMCFSNEPGIYIPG----------KVGVRIEDCLY 343 Query: 480 VTQDSPLILS 489 VT++ + Sbjct: 344 VTENGCESFT 353 >4RGZ-A nrPDB Length = 367 Score = 235 bits (599), Expect = 4e-62, Method: Composition-based stats. Identities = 85/377 (22%), Positives = 144/377 (38%), Gaps = 48/377 (12%) Query: 117 QDNNFLYLCGFQEPDSILVLQSLPGKQLPSHKAILFVPRRDPSRELWDGPRSGTDGAIAL 176 +NF YL GF ++ +L +P + PR Sbjct: 28 PGSNFYYLTGFNPLGTL------------ERLFVLILPSEGLLTAI--APRLYEKELEEF 73 Query: 177 TGVDEAYTLEEFQHLLPKMKAETNMVWYDWMRPSHAQLHSDYMQPLTEAKAKSKNKVRGV 236 G ++ E + + K + + + +++ K + + Sbjct: 74 NGEVVLWSDSENPYKIFATKIKETFKEGEKLLIDDTMPVGVFLKA---KDIFDKYSLHPI 130 Query: 237 QQLIQRLRLIKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKFEFECRAR-GA 295 +I LR IK EI+ + A ++ + F + E L + E+ + GA Sbjct: 131 SPVISELREIKDKDEIKAHKKAAEIVDKVFYRFIEGKLEGKSERELANRIEYMIKNEFGA 190 Query: 296 DILAYPPVVAGGNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGRFTA 355 D +++ P+VA G H+ +++ I+ G++V+ D G + Y SD+TRT V G + Sbjct: 191 DDVSFEPIVASGPNGANPHHRPSHRKIRKGDVVIFDYGAKYLGYCSDVTRTVVV-GPPSE 249 Query: 356 PQAELYEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMKNIKENNAFKAAR 415 ++YE V E Q + G E + + +I + Sbjct: 250 EVKKVYEIVKEAQETAVQKVAEGIPAEVVDATARGIISK-----------------YGYG 292 Query: 416 KYCPHHVGHYLGMDVHDTPDM--PRSLPLQPGMVITIEPGIYIPEDDKDAPEKFRGLGVR 473 +Y H GH LG+DVH+ P + L+ GMV TIEPGIY+ GVR Sbjct: 293 EYFIHRTGHGLGIDVHEEPYISPGNKKILKDGMVFTIEPGIYLQG----------KFGVR 342 Query: 474 IEDDVVVTQDSPLILSA 490 IEDDV + + L+ Sbjct: 343 IEDDVALVDKKGIRLTN 359 >4QR8-A nrPDB Length = 443 Score = 226 bits (576), Expect = 2e-59, Method: Composition-based stats. Identities = 96/456 (21%), Positives = 170/456 (37%), Gaps = 61/456 (13%) Query: 73 ALRRHKLMSLIQKEAQGQSGTDQTVVVLSNPTYYMSNDIPYTFHQDNNF-LYLCGFQEPD 131 + ++A + D ++ +D PY F + F ++ Q P+ Sbjct: 8 YKNHIATLQERTRDALARFKLDALLIHSGELFNVFLDDHPYPFKVNPQFKAWVPVTQVPN 67 Query: 132 SILVLQSLPGKQLPSHKAILFVPRRDPSRELWDGPRSGTDGAIALTGVDEAYTLEEFQHL 191 L++ + + + F D + P S + + + +A + L Sbjct: 68 CWLLVDGV------NKPKLWFYLPVDYWHNVEPLPTSFWTEDVEVIALPKA---DGIGSL 118 Query: 192 LPKMKAETNMVWYDWMRPSHAQLHSDYMQPLTEAKAKSKNKVRGVQQLIQRLRLIKSPAE 251 LP + + R L S +GV + R K+ E Sbjct: 119 LPAARGNIGYIGPVPER------------ALQLGIEASNINPKGVIDYLHYYRSFKTEYE 166 Query: 252 IERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKFEFECRARGADILAYPPVVAGGNRSN 311 + M+ A K+ ++ + E + + R D+ Y +VA + Sbjct: 167 LACMREAQKMAVNGHRAAEEAFRSGMSEFDINIAYLTATGHRDTDVP-YSNIVALNEHAA 225 Query: 312 TLHYVK-NNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGRFTAPQAELYEAVLEIQRD 370 LHY K ++Q ++ LLD G E + Y +D+TRTW + + A+L + V + Q Sbjct: 226 VLHYTKLDHQAPEEMRSFLLDAGAEYNGYAADLTRTW--SAKSDNDYAQLVKDVNDEQLA 283 Query: 371 CLALCFPGTSLENIYSMMLTLIGQKLKDLGIMKNIKENNAFKA--ARKYCPHHVGHYLGM 428 +A G S + + I + L+ I+ ++ E + + PH +GH LG+ Sbjct: 284 LIATMKAGVSYVDYHIQFHQRIAKLLRKHQIITDMSEEAMVENDLTGPFMPHGIGHPLGL 343 Query: 429 DVHDT------------------PDMPRSLPLQPGMVITIEPGIYIPE-----------D 459 VHD P + + LQPGMV+TIEPGIY E Sbjct: 344 QVHDVAGFMQDDSGTHLAAPAKYPYLRCTRILQPGMVLTIEPGIYFIESLLAPWREGQFS 403 Query: 460 DKDAPEKFRGL----GVRIEDDVVVTQDSPLILSAD 491 +K L G+RIED+VV+ +++ ++ D Sbjct: 404 KHFNWQKIEALKPFGGIRIEDNVVIHENNVENMTRD 439 >4ZWP-A nrPDB Length = 440 Score = 221 bits (562), Expect = 8e-58, Method: Composition-based stats. Identities = 90/429 (20%), Positives = 153/429 (35%), Gaps = 84/429 (19%) Query: 110 DIPYTFHQDNNF-LYLCGFQEPDSILVLQSLPGKQLPSHKAILFVPRRDPSRELWDGPRS 168 D+ Y F + F +L P +V ++F D ++ D P Sbjct: 45 DMYYPFKVNPQFKAWLPVIDNPHCWIVANG------TDKPKLIFYRPVDFWHKVPDEP-- 96 Query: 169 GTDGAIALTGVDEAYTLEEFQHLLPKMKAETNMVWYDWMRPSHAQLHSDYMQPLTEAKAK 228 + ++ ++ + LLP KA + +Y++ +A Sbjct: 97 -NEYWADYFDIELLVKPDQVEKLLPYDKARFAYI-------------GEYLEV-AQALGF 141 Query: 229 SKNKVRGVQQLIQRLRLIKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKFEF 288 V R K+ E+ M+ A K+ Q +AF K EF Sbjct: 142 ELMNPEPVMNFYHYHRAYKTQYELACMREANKIAVQG--------HKAARDAFFQGKSEF 193 Query: 289 ECR-------ARGADILAYPPVVAGGNRSNTLHYVKNNQLI-KDGEMVLLDGGCESSCYV 340 E + + + +VA LHY +++ L+D G + Y Sbjct: 194 EIQQAYLLATQHSENDTPFGNIVALNENCAILHYTHFDRVAPATHRSFLIDAGANFNGYA 253 Query: 341 SDITRTWPVNGRFTAPQAELYEAVLEIQRDCLALC---FPGTSLENIYSMMLTLIGQKLK 397 +DITRT+ G E E V +++ +ALC PG ++ + Q L Sbjct: 254 ADITRTYDFTGE-----GEFAELVATMKQHQIALCNQLAPGKLYGELHLDCHQRVAQTLS 308 Query: 398 DLGIMK-NIKENNAFKAARKYCPHHVGHYLGMDVHDT------------------PDMPR 438 D I+ + E A + PH +GH++G+ VHD P + Sbjct: 309 DFNIVNLSADEIVAKGITSTFFPHGLGHHIGLQVHDVGGFMADEQGAHQEPPEGHPFLRC 368 Query: 439 SLPLQPGMVITIEPGIYIPE----------------DDKDAPEKFRGLGVRIEDDVVVTQ 482 + ++ V TIEPG+Y + DK A K G G+RIED+++V + Sbjct: 369 TRKIEANQVFTIEPGLYFIDSLLGDLAATDNNQHINWDKVAELKPFG-GIRIEDNIIVHE 427 Query: 483 DSPLILSAD 491 DS ++ + Sbjct: 428 DSLENMTRE 436 >3L7G-A nrPDB Length = 517 Score = 220 bits (559), Expect = 1e-57, Method: Composition-based stats. Identities = 89/426 (20%), Positives = 150/426 (35%), Gaps = 78/426 (18%) Query: 110 DIPYTFHQDNNF-LYLCGFQEPDSILVLQSLPGKQLPSHKAILFVPRRDPSRELWDGPRS 168 D+ Y F + F +L P +V ++F D ++ D P Sbjct: 45 DMYYPFKVNPQFKAWLPVIDNPHCWIVANG------TDKPKLIFYRPVDFWHKVPDEP-- 96 Query: 169 GTDGAIALTGVDEAYTLEEFQHLLPKMKAETNMVWYDWMRPSHAQLHSDYMQPLTEAKAK 228 + ++ ++ + LLP KA + +Y++ +A Sbjct: 97 -NEYWADYFDIELLVKPDQVEKLLPYDKARFAYI-------------GEYLEV-AQALGF 141 Query: 229 SKNKVRGVQQLIQRLRLIKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKFEF 288 V R K+ E+ M+ A K+ Q +AF K EF Sbjct: 142 ELMNPEPVMNFYHYHRAYKTQYELACMREANKIAVQG--------HKAARDAFFQGKSEF 193 Query: 289 ECR-------ARGADILAYPPVVAGGNRSNTLHYVKNNQLI-KDGEMVLLDGGCESSCYV 340 E + + Y +VA LHY +++ L+D G + Y Sbjct: 194 EIQQAYLLATQHSENDNPYGNIVALNENCAILHYTHFDRVAPATHRSFLIDAGANFNGYA 253 Query: 341 SDITRTWPVNGRFTAPQAELYEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLG 400 +DITRT+ G AEL + + Q + PG ++ + Q L D Sbjct: 254 ADITRTYDFTGE--GEFAELVATMKQHQIALMNQLAPGKLYGELHLDCHQRVAQTLSDFN 311 Query: 401 IMK-NIKENNAFKAARKYCPHHVGHYLGMDVHDT------------------PDMPRSLP 441 I+ + E A + PH +GH++G+ VHD P + + Sbjct: 312 IVDLSADEIVAKGITSTFFPHGLGHHIGLQVHDVGGFMADEQGAHQEPPEGHPFLRCTRK 371 Query: 442 LQPGMVITIEPGIYIPE----------------DDKDAPEKFRGLGVRIEDDVVVTQDSP 485 ++ V TIEPG+Y + DK A K G G+RIED+++V +DS Sbjct: 372 IEANQVFTIEPGLYFIDSLLGDLAATDNNQHINWDKVAELKPFG-GIRIEDNIIVHEDSL 430 Query: 486 LILSAD 491 ++ + Sbjct: 431 ENMTRE 436 >4A6V-A nrPDB Length = 265 Score = 216 bits (551), Expect = 1e-56, Method: Composition-based stats. Identities = 67/279 (24%), Positives = 109/279 (39%), Gaps = 42/279 (15%) Query: 246 IKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFL------YAKFEFECRARGADILA 299 IK+P +IE+M++AG+L ++ K V L Y E + Sbjct: 5 IKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHG 64 Query: 300 YPPVVAGGNRSNTLHYVKNN-QLIKDGEMVLLDGGCESSCYVSDITRTWPVNGRFTAPQA 358 YP V H + ++ +L+KDG++V +D + D ++ + V G+ T Sbjct: 65 YPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIV-GKPTIMGE 123 Query: 359 ELYEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMKNIKENNAFKAARKYC 418 L E L + PG +L I + ++ E F R+YC Sbjct: 124 RLCRITQESLYLALRMVKPGINLREIGA--------------AIQKFVEAEGFSVVREYC 169 Query: 419 PHHVGHYLGMDVHDTPDM------PRSLPLQPGMVITIEPG-------IYIPEDDKDAPE 465 GH +G H+ P + ++ L+PGM TIEP I +D Sbjct: 170 ----GHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKT 225 Query: 466 KFRGLGVRIEDDVVVTQDSPLILSADCPKEMNDIEQICS 504 K R L + E +VVT + IL+ ++ + I I S Sbjct: 226 KDRSLSAQYEHTIVVTDNGCEILT---LRKDDTIPAIIS 261 >5CE6-A nrPDB Length = 480 Score = 208 bits (530), Expect = 3e-54, Method: Composition-based stats. Identities = 85/462 (18%), Positives = 171/462 (37%), Gaps = 70/462 (15%) Query: 72 YALRRHKLMSLIQKEAQGQSGTDQTVVVLSNPTYYMSNDIPYTFHQDNNFLYLCGFQEPD 131 + R S G+ + V P S D+ Y FL+L GF+ P+ Sbjct: 29 FQTRLKAFYSHWDDRRTDLWGSSDAIAVACPPP---SEDLRYL-KSTALFLWLLGFEFPE 84 Query: 132 SILVLQSLPGKQLPSHK-AILFVPRRDPSRE-------LWDGPRSGTDGAIALTGVDEAY 183 +I+V L S K A + + P+RE L P++ DGA ++ + A Sbjct: 85 TIMVFTKKQIHVLCSQKKASILESVKKPARESVGVEIILHVKPKND-DGASSMDAIIRA- 142 Query: 184 TLEEFQHLLPKMKAETNMVWYDWMRPSH---AQLHSDYMQPLTEAKAKSKNKVRGVQQLI 240 ++A++ +D H + + E SK ++ V Sbjct: 143 -----------IRAQSKSDGHDSSTVGHIAREEPEGRLLDLWAEKLKNSKFRLSDVANGF 191 Query: 241 QRLRLIKSPAEIERMQIAGKLTS---QAFIETMFTSKAPVEEAFLY-------------- 283 L KS EI ++ A LT + F+ T + E+ L+ Sbjct: 192 SALFAAKSNEEITYIKRAAYLTGSVMKNFVVTKLENVIDEEKKILHSTLMEETEKVILDP 251 Query: 284 AKFEFECRARGADILAYPPVVAGGNRSNT-LHYVKNNQLI--KDGEMVLLDGGCESSCYV 340 AK + +A D + YPP+ G + + V N++ + +++ G Y Sbjct: 252 AKVNCKLKADNVD-ICYPPIFQSGGKFDLRPSAVSNDEALYYDSASVIICAVGARYKSYC 310 Query: 341 SDITRTWPVNGRFTAPQAELYEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLG 400 S+I RT+ ++ Q++ YE +L+ Q + PG L Y ++++ + D+ Sbjct: 311 SNIARTFLIDA--DPIQSKAYEVLLKAQEAVIGSLKPGNKLSAAYLAAVSVVEKDAPDMV 368 Query: 401 IMKNIKENNAFKAARKYCPHHVGHYLGMDVHDTP---DMPRSLPLQPGMVITIEPGIYIP 457 G +G++ ++ + ++ GMV + G + Sbjct: 369 SC---------------LTKSAGTGIGIEFRESGLNINAKNDQIVKEGMVFNVSLG-FQN 412 Query: 458 EDDKDAPEKFRGLGVRIEDDVVVTQDSPLILSADCPKEMNDI 499 +++ K + + + D +++ +D ++++ K + D+ Sbjct: 413 LHCENSKSKNKVFSLLLADTIIINKDKTDVVTSIGSKALKDV 454 >4FO7-A nrPDB Length = 280 Score = 208 bits (530), Expect = 4e-54, Method: Composition-based stats. Identities = 63/263 (23%), Positives = 104/263 (39%), Gaps = 38/263 (14%) Query: 246 IKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFL------YAKFEFECRARGADILA 299 IK+P +IE+M+IAG+L ++ K V L Y E + + Sbjct: 5 IKTPDDIEKMRIAGRLAAEVLEMIGEHIKPGVTTEELDRICHDYIVNEQKAIPAPLNYKG 64 Query: 300 YPPVVAGGNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGRFTAPQAE 359 +P + H + N + +K+G+++ +D Y D ++ + V G+ Sbjct: 65 FPKSICTSINHVVCHGIPNEKPLKEGDILNVDITVIKDGYHGDTSKMFLV-GKTPEWADR 123 Query: 360 LYEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMKNIKENNAFKAARKYCP 419 L + E +++ PG L +I I++ E N F R+YC Sbjct: 124 LCQITQECMYKGISVVRPGAHLGDIGE--------------IIQKHAEKNGFSVVREYC- 168 Query: 420 HHVGHYLGMDVHDTPDM------PRSLPLQPGMVITIEPGIY-------IPEDDKDAPEK 466 GH +G H+ P + + L+ GM+ TIEP I + D A K Sbjct: 169 ---GHGIGKVFHEEPQVLHYGRAGTGIELKEGMIFTIEPMINQGRPETRLLGDGWTAITK 225 Query: 467 FRGLGVRIEDDVVVTQDSPLILS 489 R L + E V+VT D IL+ Sbjct: 226 DRKLSAQWEHTVLVTADGYEILT 248 >4KM3-A nrPDB Length = 286 Score = 198 bits (502), Expect = 6e-51, Method: Composition-based stats. Identities = 66/283 (23%), Positives = 111/283 (39%), Gaps = 45/283 (15%) Query: 246 IKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKFEFECRAR-------GAD-- 296 +KS EIE M AG + I K V+ + C+ G D Sbjct: 4 LKSAREIEAMDKAGDFLASIHIGLRDLIKPGVDMWEVEEYVRRRCKEENFLPLQIGVDGA 63 Query: 297 ILAYPPVVAGGNRSNTLHYVKNNQLIKDGEMVLLD---GG--CESSCYVSDITRTWPVNG 351 ++ YP H + ++KDG+++ +D GG +S VS + N Sbjct: 64 MMDYPYATCCSLNDEVAHAFPRHYILKDGDLLKVDMVLGGPIAKSDLNVSKLNFN---NV 120 Query: 352 RFTAPQAELYEAVLEIQRDCLALCFPGTSLENIYSMM---------LTLIGQKLKDLG-I 401 + Y L A+ P ++N+ + ++G ++ D+G Sbjct: 121 EQMKKYTQSYSGGLADSCWAYAVGTPSEEVKNLMDITKEAMYKGIEQAVVGNRIGDIGAA 180 Query: 402 MKNIKENNAFKAARKYCPHHVGHYLGMDVHDTPDMP------RSLPLQPGMVITIEPGIY 455 ++ E+ + R VGH +G +H+ P +P R L L+ GMV+TIEP I Sbjct: 181 IQEYAESRGYGVVRDL----VGHGVGPTMHEEPMVPNYGIAGRGLRLREGMVLTIEPMIN 236 Query: 456 IPEDDKDAPEK--------FRGLGVRIEDDVVVTQDSPLILSA 490 + + D K GL + E V+T+D P+IL++ Sbjct: 237 TGDWEIDTDMKTGWAHKTIDGGLSCQYEHQFVITKDGPVILTS 279 >6MRF-A nrPDB Length = 270 Score = 194 bits (493), Expect = 6e-50, Method: Composition-based stats. Identities = 57/272 (20%), Positives = 100/272 (36%), Gaps = 44/272 (16%) Query: 245 LIKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFL------YAKFEFECRARGADI- 297 +IK+P EIE+M+IAG+L ++ KA V L + + Sbjct: 9 MIKTPDEIEKMRIAGRLAAEVLDMIKPHIKAGVSTLELDTICRNHIENVQHAIPACVGYG 68 Query: 298 -----LAYPPVVAGGNRSNTLHYVKN-NQLIKDGEMVLLDGGCESSCYVSDITRTWPVNG 351 A+ + H + + N+++K+G+++ +D Y D + V G Sbjct: 69 GAPGRPAFQHSICTSVNHVVCHGIPSENKILKNGDILNIDVTVIKDGYHGDTNMMYIVGG 128 Query: 352 RFTAPQAELYEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMKNIKENNAF 411 + L + E +A G+ L +I ++ E+ F Sbjct: 129 ETSILANRLCKVAQEAMYRGMATVRDGSYLGDIGH--------------AIQKYVESERF 174 Query: 412 KAARKYCPHHVGHYLGMDVHDTPDM------PRSLPLQPGMVITIEPGIY-------IPE 458 R+YC GH +G HD P + + L+ GM TIEP + + Sbjct: 175 SVVREYC----GHGIGTVFHDEPQVLHYGQAGTGMRLEAGMTFTIEPMVNAGVWQTKLLG 230 Query: 459 DDKDAPEKFRGLGVRIEDDVVVTQDSPLILSA 490 D K L + E ++VT+ +L+A Sbjct: 231 DKWTVVTKDHKLSAQYEHTILVTKTGIEVLTA 262 >1O0X-A nrPDB Length = 262 Score = 183 bits (465), Expect = 1e-46, Method: Composition-based stats. Identities = 56/267 (20%), Positives = 99/267 (37%), Gaps = 42/267 (15%) Query: 246 IKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFLYA-------KFEFECRARGADIL 298 IK+P+EIE+M+ AGK + A E + K + +G Sbjct: 16 IKTPSEIEKMKKAGKAVAVALREVRKVIVPGKTAWDVETLVLEIFKKLRVKPAFKGYGGY 75 Query: 299 AYPPVVAGGNRSNTLHYVK-NNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGRFTAPQ 357 Y V+ +H + ++ K+G++V +D G D T+ V G Sbjct: 76 KYATCVSV--NEEVVHGLPLKEKVFKEGDIVSVDVGAVYQGLYGDAAVTYIV-GETDERG 132 Query: 358 AELYEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMKNIKENNAFKAARKY 417 EL E+ + + PG L ++ ++ E+ F R Y Sbjct: 133 KELVRVTREVLEKAIKMIKPGIRLGDVSHC--------------IQETVESVGFNVIRDY 178 Query: 418 CPHHVGHYLGMDVHDTPDMPR------SLPLQPGMVITIEPGIY-------IPEDDKDAP 464 VGH +G ++H+ P +P + L+ GM + IEP + + ED A Sbjct: 179 ----VGHGVGRELHEDPQIPNYGTPGTGVVLRKGMTLAIEPMVSEGDWRVVVKEDGWTAV 234 Query: 465 EKFRGLGVRIEDDVVVTQDSPLILSAD 491 E +++T++ IL+ + Sbjct: 235 TVDGSRCAHFEHTILITENGAEILTKE 261 >3TB5-A nrPDB Length = 264 Score = 181 bits (460), Expect = 5e-46, Method: Composition-based stats. Identities = 55/264 (20%), Positives = 104/264 (39%), Gaps = 39/264 (14%) Query: 246 IKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKFEFECRARG-----ADILAY 300 +KSP EIE M +G+L + K + + + G Y Sbjct: 4 LKSPREIEMMDESGELLADVHRHLRTFIKPGITSWDIEVFVRDFIESHGGVAAQIGYEGY 63 Query: 301 PPVVAGGNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGRFTAPQAEL 360 H +++KDG+++ +D + +SD ++ V G T Sbjct: 64 KYATCCSINDEICHGFPRKKVLKDGDLIKVDMCVDLKGAISDSCWSYVV-GESTPE---- 118 Query: 361 YEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLG-IMKNIKENNAFKAARKYCP 419 + ++E+ + L L + +G ++ D+G ++ E + R + Sbjct: 119 IDRLMEVTKKALYL-----------GIEQAQVGNRIGDIGHAIQTYVEGEGYGVVRDF-- 165 Query: 420 HHVGHYLGMDVHDTPDMP------RSLPLQPGMVITIEPGIYIP-------EDDKDAPEK 466 VGH +G +H++P +P + L L+ GMVITIEP + + A + Sbjct: 166 --VGHGIGPTIHESPMIPHYGEAGKGLRLKEGMVITIEPMVNTGTWRMKMDPNGWTAYTE 223 Query: 467 FRGLGVRIEDDVVVTQDSPLILSA 490 GL + E + +T++ P IL++ Sbjct: 224 DGGLSCQYEHSLAITKEGPRILTS 247 >1QXW-A nrPDB Length = 252 Score = 169 bits (428), Expect = 3e-42, Method: Composition-based stats. Identities = 48/265 (18%), Positives = 101/265 (38%), Gaps = 37/265 (13%) Query: 245 LIKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKF-----EFECRARGADILA 299 ++K+ E++ ++ G + ++ +K + L E+ + Sbjct: 2 IVKTEEELQALKEIGYICAKVRNTMQAATKPGITTKELDNIAKELFEEYGAISAPIHDEN 61 Query: 300 YPPVVAGGNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGRFTAPQAE 359 +P H + + ++I++G++V +D + Y +D ++ V + + Sbjct: 62 FPGQTCISVNEEVAHGIPSKRVIREGDLVNIDVSALKNGYYADTGISFVVGESDDPMKQK 121 Query: 360 LYEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMKNIKENNAFKAARKYCP 419 + + + +A PGT L NI + Q DL ++KN+ Sbjct: 122 VCDVATMAFENAIAKVKPGTKLSNIGKAVHNTARQN--DLKVIKNL-------------- 165 Query: 420 HHVGHYLGMDVHDTP-------DMPRSLPLQPGMVITIEPGIYI-------PEDDKDAPE 465 GH +G+ +H+ P D L GMV+ IEP I +++ Sbjct: 166 --TGHGVGLSLHEAPAHVLNYFDPKDKTLLTEGMVLAIEPFISSNASFVTEGKNEWAFET 223 Query: 466 KFRGLGVRIEDDVVVTQDSPLILSA 490 + +IE V+VT+D P++ + Sbjct: 224 SDKSFVAQIEHTVIVTKDGPILTTK 248 >3MR1-A nrPDB Length = 252 Score = 169 bits (427), Expect = 4e-42, Method: Composition-based stats. Identities = 50/263 (19%), Positives = 91/263 (34%), Gaps = 38/263 (14%) Query: 246 IKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKFEFECRARGA-----DILAY 300 I + + +M+ AGKL ++ K V L + A + + Sbjct: 8 IHTEKDFIKMRAAGKLAAETLDFITDHVKPNVTTNSLNDLCHNFITSHNAIPAPLNYKGF 67 Query: 301 PPVVAGGNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGRFTAPQAEL 360 P + H + N++ +K+G++V +D + D +R + V G L Sbjct: 68 PKSICTSINHVVCHGIPNDKPLKNGDIVNIDVTVILDGWYGDTSRMYYV-GDVAIKPKRL 126 Query: 361 YEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMKNIKENNAFKAARKYCPH 420 + + + + PG L +I +++ E + + R Y Sbjct: 127 IQVTYDAMMKGIEVVRPGAKLGDIGY--------------AIQSYAEKHNYSVVRDY--- 169 Query: 421 HVGHYLGMDVHDTPDM------PRSLPLQPGMVITIEPGIYIPE--------DDKDAPEK 466 GH +G HD P + L L+ GM T+EP I D + Sbjct: 170 -TGHGIGRVFHDKPSILNYGRNGTGLTLKEGMFFTVEPMINAGNYDTILSKLDGWTVTTR 228 Query: 467 FRGLGVRIEDDVVVTQDSPLILS 489 + L + E + VT+D I + Sbjct: 229 DKSLSAQFEHTIGVTKDGFEIFT 251 >3CTZ-A nrPDB Length = 623 Score = 165 bits (418), Expect = 3e-41, Method: Composition-based stats. Identities = 63/260 (24%), Positives = 103/260 (39%), Gaps = 47/260 (18%) Query: 240 IQRLRLIKSPAEIERMQIAGKLTSQAFIETMFT-----SKAPVEEAFLYAKFEFECRARG 294 I + +K+ AE E M+ A + A E K V E K E E R + Sbjct: 315 ICIAKAVKNSAESEGMRRAHIKDAVALCELFNWLEKEVPKGGVTEISAADKAE-EFRRQQ 373 Query: 295 ADI--LAYPPVVAGGNRSNTLHYVK---NNQLIKDGEMVLLDGGCESSCYVSDITRTWPV 349 AD L++P + + G +HY N+ + E+ L+D G + +D+TRT Sbjct: 374 ADFVDLSFPTISSTGPTGAIIHYAPVPETNRTLSLDEVYLIDSGAQYKDGTTDVTRTMHF 433 Query: 350 NGRFTAPQAELYEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMKNIKENN 409 TA + E + VL+ A FP + ++ + + + Sbjct: 434 E-TPTAYEKECFTYVLKGHIAVSAAVFPTGTKGHL-----------------LDSFARSA 475 Query: 410 AFKAARKYCPHHVGHYLG--MDVHDTP-----DMPRSLPLQPGMVITIEPGIYIPEDDKD 462 + + Y H GH +G ++VH+ P PL+ GM++T EPG Y Sbjct: 476 LWDSGLDYL-HGTGHGVGSFLNVHEGPCGISYKTFSDEPLEAGMIVTDEPGYY------- 527 Query: 463 APEKFRGLGVRIEDDVVVTQ 482 + G+RIE+ V+V Sbjct: 528 ---EDGAFGIRIENVVLVVP 544 >3ROR-A nrPDB Length = 291 Score = 163 bits (411), Expect = 3e-40, Method: Composition-based stats. Identities = 51/264 (19%), Positives = 89/264 (33%), Gaps = 41/264 (15%) Query: 246 IKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFL-----YAKFEFECRARGADILAY 300 +++P IE+M++AG++ + A E V L + + Sbjct: 47 VQTPEVIEKMRVAGRIAAGALAEAGKAVAPGVTTDELDRIAHEYLVDNGAYPSTLGYKGF 106 Query: 301 PPVVAGGNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGRFTAPQAEL 360 P + H + ++ +I DG++V +D D T+P G L Sbjct: 107 PKSCSTSLNEVICHGIPDSTVITDGDIVNIDVTAYIGGVHGDTNATFPA-GDVADEHRLL 165 Query: 361 YEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMKNIKENNAFKAARKYCPH 420 + E + PG +L I ++++ + R + Sbjct: 166 VDRTREATMRAINTVKPGRALSVIGR--------------VIESYANRFGYNVVRDF--- 208 Query: 421 HVGHYLGMDVH--------DTPDMPRSLPLQPGMVITIEPGIYIP-------EDDKDAPE 465 GH +G H D P + +QPGM TIEP I + +D Sbjct: 209 -TGHGIGTTFHNGLVVLHYDQPAV--ETIMQPGMTFTIEPMINLGALDYEIWDDGWTVVT 265 Query: 466 KFRGLGVRIEDDVVVTQDSPLILS 489 K R + E ++VT IL+ Sbjct: 266 KDRKWTAQFEHTLLVTDTGVEILT 289 >4IU6-A nrPDB Length = 384 Score = 158 bits (400), Expect = 4e-39, Method: Composition-based stats. Identities = 49/261 (18%), Positives = 86/261 (32%), Gaps = 37/261 (14%) Query: 248 SPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKFEFECRARGA-----DILAYPP 302 S +IE M++ +L + K V + C AR + +P Sbjct: 132 SSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPK 191 Query: 303 VVAGGNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGRFTAPQAELYE 362 H + + + +++G++V +D + Y D+ T+ V G +L + Sbjct: 192 SCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFV-GEVDDGARKLVQ 250 Query: 363 AVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMKNIKENNAFKAARKYCPHHV 422 E + PG + I++ + N F R YC Sbjct: 251 TTYECLMQAIDAVKPGVRYRELG--------------NIIQKHAQANGFSVVRSYC---- 292 Query: 423 GHYLGMDVHDTPDMPRSL------PLQPGMVITIEPGI-------YIPEDDKDAPEKFRG 469 GH + H P++P ++ G V TIEP I D A + Sbjct: 293 GHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGK 352 Query: 470 LGVRIEDDVVVTQDSPLILSA 490 + E ++VT IL+ Sbjct: 353 RSAQFEHTLLVTDTGCEILTR 373 >2B3K-A nrPDB Length = 329 Score = 157 bits (397), Expect = 1e-38, Method: Composition-based stats. Identities = 49/261 (18%), Positives = 86/261 (32%), Gaps = 37/261 (14%) Query: 248 SPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKFEFECRARGA-----DILAYPP 302 S +IE M++ +L + K V + C AR + +P Sbjct: 77 SSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPK 136 Query: 303 VVAGGNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGRFTAPQAELYE 362 H + + + +++G++V +D + Y D+ T+ V G +L + Sbjct: 137 SCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFV-GEVDDGARKLVQ 195 Query: 363 AVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMKNIKENNAFKAARKYCPHHV 422 E + PG + I++ + N F R YC Sbjct: 196 TTYECLMQAIDAVKPGVRYRELG--------------NIIQKHAQANGFSVVRSYC---- 237 Query: 423 GHYLGMDVHDTPDMPRSL------PLQPGMVITIEPGI-------YIPEDDKDAPEKFRG 469 GH + H P++P ++ G V TIEP I D A + Sbjct: 238 GHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGK 297 Query: 470 LGVRIEDDVVVTQDSPLILSA 490 + E ++VT IL+ Sbjct: 298 RSAQFEHTLLVTDTGCEILTR 318 >4S2R-P nrPDB Length = 639 Score = 148 bits (372), Expect = 8e-36, Method: Composition-based stats. Identities = 66/291 (22%), Positives = 107/291 (36%), Gaps = 59/291 (20%) Query: 213 QLHSDYMQPLTEAKAKS----KNKVRGVQQLIQRLRLIKSPAEIERMQIAGKLTSQAFIE 268 + H Y+ P T S +N + L+Q + K+ E++ M+ + S A +E Sbjct: 304 EPHMVYLTPETNYAIGSIIGEENSMVDTS-LVQTAKATKNDHEMQGMRNSHLRDSAALVE 362 Query: 269 TMFTSKAPVEEAFLYAKFEFECRARGAD-------ILAYPPVVAGGNRSNTLHYVK---- 317 + + + Y + E + L++ + A G+ + HY Sbjct: 363 FLCWLEKELLSGKRYTEIELADKIDHLRSLQDKYVTLSFDTISAVGDHAALPHYKPLGES 422 Query: 318 NNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGRFTAPQAELY---EAVLEIQRDCLAL 374 N+ ++ LLD G +D+TRT +T P E VL+ + Sbjct: 423 GNRKAAANQVFLLDSGAHYGDGTTDVTRTV----WYTNPPKEFILHNTLVLKGHINLARA 478 Query: 375 CFPGTSLENIYSMMLTLIGQKLKDLGIMKNIKENNAFKAARKYCPHHVGHYLG--MDVHD 432 FP S + TL L LG+ H GH +G ++VH+ Sbjct: 479 KFPDGIYG---SRLDTLTRDALWKLGLD---------------FEHGTGHGVGHYLNVHE 520 Query: 433 TP------DMPRSLPLQPGMVITIEPGIYIPEDDKDAPEKFRGLGVRIEDD 477 P +P L V+TIEPG Y A EK+ G+RIE+ Sbjct: 521 GPIGIGHRSVPTGGELHASQVLTIEPGFY-------AKEKY---GIRIENC 561 >3S6B-A nrPDB Length = 368 Score = 144 bits (362), Expect = 1e-34, Method: Composition-based stats. Identities = 49/263 (18%), Positives = 87/263 (33%), Gaps = 38/263 (14%) Query: 248 SPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKFEFECRARGA-----DILAYPP 302 + EI+R++ A L + V + K A + +P Sbjct: 105 NEEEIQRIREACILGRKTLDYAHTLVSPGVTTDEIDRKVHEFIIKNNAYPSTLNYYKFPK 164 Query: 303 VVAGGNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGRFT--APQAEL 360 H + + + +K G+++ +D SD+ T+ V EL Sbjct: 165 SCCTSVNEIVCHGIPDYRPLKSGDIINIDISVFYKGVHSDLNETYFVGDINDVPKEGKEL 224 Query: 361 YEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMKNIKENNAFKAARKYCPH 420 E + + C PG +NI +++ + +K F R Y Sbjct: 225 VETCYFSLMEAIKKCKPGMFYKNIGTLIDAYVSKK--------------NFSVVRSY--- 267 Query: 421 HVGHYLGMDVHDTPDMPRSL------PLQPGMVITIEPGIY-------IPEDDKDAPEKF 467 GH +G H P +P ++PG V TIEP I + D + Sbjct: 268 -SGHGVGKLFHSNPTVPHFKKNKAVGIMKPGHVFTIEPMINQGHYSDVLWPDQWTSATSD 326 Query: 468 RGLGVRIEDDVVVTQDSPLILSA 490 L + E +++T + IL+ Sbjct: 327 GKLSAQFEHTLLITNNGVEILTK 349 >4FUK-A nrPDB Length = 337 Score = 143 bits (359), Expect = 3e-34, Method: Composition-based stats. Identities = 60/324 (18%), Positives = 104/324 (32%), Gaps = 41/324 (12%) Query: 184 TLEEFQHLLPKMKAETNMVWYDWMRPSHAQLHSDYMQPLTEAKAKSKNKVRGVQQLIQRL 243 T + L P V +RP +A + E SK KV + Q + Sbjct: 5 TFDFTGPLRPGKITPRRAVPSHILRPDYADRAGG-VSASEEKDRGSKVKVYNI-QFLHD- 61 Query: 244 RLIKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFL-----YAKFEFECRARGADIL 298 K AEI+R++ +L+ + +K + L A E + Sbjct: 62 -DSKKTAEIQRIKTVCQLSREVLDIATAAAKPGITTDELDRIVHEATVERNMYPSPLNYY 120 Query: 299 AYPPVVAGGNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGRFTAPQA 358 +P V H + +++ +++G+++ +D + + D+ T GR Sbjct: 121 GFPKSVCTSVNEVICHGIPDSRELEEGDILNIDVSSYLNGFHGDLNET-VFIGRPDDDSV 179 Query: 359 ELYEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMKNIKENNAFKAARKYC 418 L A E + + P + + + Q R Y Sbjct: 180 RLVHAAYECLCAGIGVVKPEALYKQVGDAIEACASQY--------------QCSVVRTYT 225 Query: 419 PHHVGHYLGMDVHDTPDM------PRSLPLQPGMVITIEPGIYIP-------EDDKDAPE 465 H VGH H +P + ++PG V TIEP I + D + Sbjct: 226 GHGVGH----LFHTSPTVCHYANNKSLGMMRPGHVFTIEPMINLGTWQDVTWPDKWTSTT 281 Query: 466 KFRGLGVRIEDDVVVTQDSPLILS 489 K + E +VVT I + Sbjct: 282 KDGRRSAQFEHTMVVTNGGVEIFT 305 >3TAV-A nrPDB Length = 286 Score = 137 bits (345), Expect = 1e-32, Method: Composition-based stats. Identities = 58/262 (22%), Positives = 90/262 (34%), Gaps = 32/262 (12%) Query: 247 KSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKFEFECRARGA-----DILAYP 301 ++P E++ M AG + A + +KA V L E R GA +P Sbjct: 35 RTPGELDAMAAAGSIVGAALVAVRDAAKAGVSTLELDQVAESVIREAGAVPSFLGYHGFP 94 Query: 302 PVVAGGNRSNTLHYVKN-NQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGRFTAPQAEL 360 + +H + + ++ DG++V +D G + D T+ V G L Sbjct: 95 ASICSSVNDQVVHGIPSATAVLADGDLVSIDCGAILDGWHGDSAWTFAV-GTVIPSDEAL 153 Query: 361 YEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMKNIKENNAFKAARKYCPH 420 EA +A PG L ++ + +L K AF Y Sbjct: 154 SEATRLSMEAGIAAMIPGNRLTDVSHAI------ELGTRAAEKQFDR--AFGIVDGYG-- 203 Query: 421 HVGHYLGMDVHDTPDMPR------SLPLQPGMVITIEPGI-------YIPEDDKDAPEKF 467 GH +G +H P +P L G V+ IEP + + DD Sbjct: 204 --GHGIGRSMHLDPFLPNEGAPGKGPLLAVGSVLAIEPMLTLGTTQTRVLADDWTVVTTD 261 Query: 468 RGLGVRIEDDVVVTQDSPLILS 489 E V VT+ P IL+ Sbjct: 262 GSRAAHWEHTVAVTEAGPRILT 283 >5JR6-A nrPDB Length = 664 Score = 134 bits (336), Expect = 1e-31, Method: Composition-based stats. Identities = 58/283 (20%), Positives = 106/283 (37%), Gaps = 48/283 (16%) Query: 211 HAQLHSDYMQPLTEAKAKSKNKVRGVQQLIQRLRLIKSPAEIERMQIAGKLTSQAFIETM 270 + S Y+ + KN + +++ ++ +K+ EI+ M+ A L A ++ Sbjct: 321 YDISLSPYINLMIYKLFDRKNVLLQNSPVVK-MKAVKNDVEIDNMKQAHILDGLALLQFF 379 Query: 271 FTSKAPVEEAFLYAKFE---------FECRARGADILAYPPVVAGGNRSNTLHYVKNNQ- 320 + + L+ + E F + ++ + A G + +HY ++ Sbjct: 380 HWCEQKRKTKELFNETEMSLRHKVDYFRSTKKNFIFPSFSTISASGPNAAVIHYECTDKT 439 Query: 321 --LIKDGEMVLLDGGCESSCYVSDITRTWPVNGRFTAPQAELYEAVLEIQRDCLALCFPG 378 IK + LLD G + +D+TRT G TA + +Y VL+ + F Sbjct: 440 NATIKPA-IYLLDSGGQYLHGTTDVTRTTHF-GEPTAEEKRIYTLVLKGHLRLRKVIFAS 497 Query: 379 TSLENIYSMMLTLIGQKLKDLGIMKNIKENNAFKAARKYCPHHVGHYLG--MDVHDTP-- 434 + + + I N F Y H GH +G ++VH+ Sbjct: 498 YT-----------------NSSALDFIARENLFNNFMDY-NHGTGHGVGLTLNVHEGGCS 539 Query: 435 -DMPRSLPLQPGMVITIEPGIYIPEDDKDAPEKFRGLGVRIED 476 PL+ MV++ EPG Y+ + GVRIE+ Sbjct: 540 IGPVGGAPLKKNMVLSNEPGYYMKD----------KFGVRIEN 572 >5E5B-A nrPDB Length = 431 Score = 107 bits (267), Expect = 1e-23, Method: Composition-based stats. Identities = 78/458 (17%), Positives = 163/458 (35%), Gaps = 59/458 (12%) Query: 67 LSQVEYALRRHKLMSLIQKEAQGQSGTDQTVVVLSNPTYYMSNDIPYTFHQDNNFL-YLC 125 L + Y R +L S +K + D VV + D + + +L Sbjct: 4 LDKDAYYRRVKRLYSNWRKGEDEYANVDAIVVSVG-------VDEEIVYAKSTALQTWLF 56 Query: 126 GFQEPDSILVLQSLPGKQLPSHKAILFVPRRDPSRELWDGPRSGTD---GAIALTGVDEA 182 G++ D+I+V K I ++ G + GA A+T + Sbjct: 57 GYELTDTIMVF--------CDDKIIFMASKKKVEFLKQIANTKGNENANGAPAITLLIRE 108 Query: 183 ---YTLEEFQHLLPKMKAETNMVWYDWMRPSHAQLHSDYMQPLTEAKAKSKNKVRGVQQL 239 F ++ +K N S + ++M+ + K + + Sbjct: 109 KNESNKSSFDKMIEAIKESKN--GKKIGVFSKDKFPGEFMKSWNDCLNKEGFDKIDISAV 166 Query: 240 IQRLRLIKSPAEIERMQIAGKLTSQAFIETMFTSK---APVEEAFLYAK--------FEF 288 + +K E+ M+ A +TS+ F + +E ++K E Sbjct: 167 VAYTIAVKEDGELNLMKKAASITSEVFNKFFKERVMEIVDADEKVRHSKLAESVEKAIEE 226 Query: 289 ECRARGAD----ILAYPPVVAGGNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDIT 344 + GAD + YPP++ G N V +++ + G Y S++ Sbjct: 227 KKYLAGADPSTVEMCYPPIIQSGGNYNLKFSVVSDKNHMHFGAITCAMGIRFKSYCSNLV 286 Query: 345 RTWPVNGRFTAPQAELYEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMKN 404 RT V+ + E Y +L++Q + L G + ++Y+ ++ ++ ++ +L + Sbjct: 287 RTLMVD--PSQEVQENYNFLLQLQEELLKELRHGVKICDVYNAVMDVVKKQKPEL--LNK 342 Query: 405 IKENNAFKAARKYCPHHVGHYLGMDVHDTPDM---PRSLPLQPGMVITIEPGIYIPEDDK 461 I +N F +G++ + + L+ GMV +I G + + Sbjct: 343 ITKNLGF-------------GMGIEFREGSLVINSKNQYKLKKGMVFSINLGFSDLTNKE 389 Query: 462 DAPEKFRGLGVRIEDDVVVTQDSPLILSADCPKEMNDI 499 + + + I D V+V +D P + K++ ++ Sbjct: 390 GKKPEEKTYALFIGDTVLVDEDGPATVLTSVKKKVKNV 427 >1CHM-A nrPDB Length = 401 Score = 99.1 bits (245), Expect = 4e-21, Method: Composition-based stats. Identities = 71/442 (16%), Positives = 149/442 (33%), Gaps = 68/442 (15%) Query: 58 LRPGE-VTPGLSQVEYALRRHKLMSLIQKEAQGQSGTDQTVVVLSNPTYYMSNDIPYTFH 116 +R G+ V S EYA R+ +L + + + + + + + + Sbjct: 8 IRNGDKVRSTFSAQEYANRQARLRAHL-------AAENIDAAIFT---------SYHNIN 51 Query: 117 QDNNFLYLCGFQEPDSILVLQSLPGKQLPSHKAILFVPRRDPSRELWDGPRSGTDGAIAL 176 ++FLY C F P +++V + + + W GTD + Sbjct: 52 YYSDFLY-CSFGRPYALVVTEDDVISISANIDG----------GQPW-RRTVGTDNIVYT 99 Query: 177 TGVDEAYTLEEFQHLLPKMKAETNMVWYDWMRPSHAQLHSDYMQPLTEAKAKSKNKVRGV 236 Q LP KA + +D + + A ++ V Sbjct: 100 DW-QRDNYFAAIQQALP--KARRIGIEHDHLNLQNRDKL---------AARYPDAELVDV 147 Query: 237 QQLIQRLRLIKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKFEFECRARGAD 296 R+R+IKS E ++ ++ + V E + AD Sbjct: 148 AAACMRMRMIKSAEEHVMIRHGARIADIGGAAVVEALGDQVPEYEVALHATQAMVRAIAD 207 Query: 297 I------LAYPPVVAGGNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVN 350 + G ++ H + + G+++ L+ + Y + + RT Sbjct: 208 TFEDVELMDTWTWFQSGINTDGAHNPVTTRKVNKGDILSLNCFPMIAGYYTALERT-LFL 266 Query: 351 GRFTAPQAELYEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMKNIKENNA 410 + L++ +E+ L L PG + I ++L ++ + ++ + Sbjct: 267 DHCSDDHLRLWQVNVEVHEAGLKLIKPGARCSD--------IARELNEIFLKHDVLQYRT 318 Query: 411 FKAARKY--CPHHVGHYLGMDVHDTPDMPRSLPLQPGMVITIEPGIYIPEDDKDAPEKFR 468 F + H+ G G+++ + L+PGMV+++EP I +PE Sbjct: 319 FGYGHSFGTLSHYYGREAGLELRED----IDTVLEPGMVVSMEPMIMLPEGLP------G 368 Query: 469 GLGVRIEDDVVVTQDSPLILSA 490 G R D ++V ++ ++ Sbjct: 369 AGGYREHDILIVNENGAENITK 390 >3CB5-A nrPDB Length = 444 Score = 98.3 bits (243), Expect = 7e-21, Method: Composition-based stats. Identities = 64/462 (13%), Positives = 158/462 (34%), Gaps = 61/462 (13%) Query: 67 LSQVEYALRRHKLMSLIQKEAQGQSGTDQTVVVLSNPTYYMSNDIPYTFHQDNNFL-YLC 125 + ++ + R L++ + E G++ +L + D + + +L Sbjct: 8 IDEITFHKRLGILLTSWKNEEDGKTLFQDCDSILVTVGAH---DDTNPYQKSTALHTWLL 64 Query: 126 GFQEPDSILVLQSLPGKQLPSHKAILFVPRRDPSRELWDGPRSGTDGAIALTGVDEAYTL 185 G++ P ++++L+ H+ + + G A + + Sbjct: 65 GYEFPSTLILLEK--------HRITILTSVNKANMLTKLAETKG--AAADVNILKRTKDA 114 Query: 186 EEFQHLLPKMKAETNMVWYDWMRPSHAQLHSDYMQPLTEAKA--KSKNKVRGVQQLIQRL 243 EE + L K+ + ++ KS+ + + + Sbjct: 115 EENKKLFEKIIEYIRATNKKVGVFPKDKTQGKFINEWDSIFEPVKSEFNLVDASLGLAKC 174 Query: 244 RLIKSPAEIERMQIAGKLTSQAFIETMFT---SKAPVEEAFLYAKFEFECRARGADIL-- 298 IK E+ ++ A +++ + + + ++KF + + + Sbjct: 175 LAIKDEQELANIKGASRVSVAVMSKYFVDELSTYIDQGKKITHSKFSDQMESLIDNEAFF 234 Query: 299 -----------------AYPPVVAGGNRSNT-LHYVKNNQLIKDGEMVLLDGGCESSCYV 340 Y P++ G + + +++ + G++VL G Y Sbjct: 235 QTKSLKLGDIDLDQLEWCYTPIIQSGGSYDLKPSAITDDRNL-HGDVVLCSLGFRYKSYC 293 Query: 341 SDITRTWPVNGRFTAPQAELYEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLG 400 S++ RT+ + + Q + Y ++ +Q+ C G + +IY+ +L LI K DL Sbjct: 294 SNVGRTYLFD--PDSEQQKNYSFLVALQKKLFEYCRDGAVIGDIYTKILGLIRAKRPDL- 350 Query: 401 IMKNIKENNAFKAARKYCPHHVGHYLGMDVHDTPDM---PRSLPLQPGMVITIEPGIYIP 457 ++G +G++ ++ + LQ GM + + G Sbjct: 351 --------------EPNFVRNLGAGIGIEFRESSLLVNAKNPRVLQAGMTLNLSIGFGNL 396 Query: 458 EDDKDAPEKFRGLGVRIEDDVVVTQDSPLILSADCPKEMNDI 499 + + + + + D + +T+ P++ + D PK DI Sbjct: 397 INPHPKNSQSKEYALLLIDTIQITRSDPIVFT-DSPKAQGDI 437 >1XGN-A nrPDB Length = 295 Score = 82.1 bits (201), Expect = 5e-16, Method: Composition-based stats. Identities = 37/206 (17%), Positives = 75/206 (36%), Gaps = 21/206 (10%) Query: 251 EIERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKFEFECRARGADILAYPPVVAGGNRS 310 + E++ AG++ + + + ++ + L E + A+P V Sbjct: 2 DTEKLMKAGEIAKKVREKAIKLARPGMLLLELAESIE-KMIMELGGKPAFP--VNLSINE 58 Query: 311 NTLHYVK---NNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGRFTAPQAELYEAVLEI 367 HY + ++K+G+ + +D G +++D T V EL EA E Sbjct: 59 IAAHYTPYKGDTTVLKEGDYLKIDVGVHIDGFIADTAVTVRVGMEED----ELMEAAKEA 114 Query: 368 QRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMKNIKENNAFKAARKYCPHHVGHYLG 427 +++ G ++ + + I ++ K I + K R Y H G Sbjct: 115 LNAAISVARAGVEIKELGKAIENEIRKR-----GFKPIVNLSGHKIER-YKLHA-----G 163 Query: 428 MDVHDTPDMPRSLPLQPGMVITIEPG 453 + + + + L+ G V IEP Sbjct: 164 ISIPNIYRPHDNYVLKEGDVFAIEPF 189 >6A8M-A nrPDB Length = 461 Score = 81.0 bits (198), Expect = 1e-15, Method: Composition-based stats. Identities = 63/456 (13%), Positives = 150/456 (32%), Gaps = 64/456 (14%) Query: 70 VEYALRRHKLMSLIQKEAQGQSGTDQTVVVLSNPTYYMSNDIPYTFHQDNNFL-YLCGFQ 128 ++++ ++L++L + V +L S D + + +L G++ Sbjct: 7 IDFSTFENRLLALRDRFPSFDGSPSSLVFILG------SADEENPYQKTTILHNWLLGYE 60 Query: 129 EPDSILVLQSLPGKQLPSHKAILFVPRRDPSRELWDGPRSGTDGAIALTGVDEAYTLEEF 188 P +++ + + S ++ + + + + + L+ F Sbjct: 61 FPTTLIAVFKEGCVVITSAAKTRYLEEGVAQMNK--KLENTFKIELWQSSKEPGHNLKLF 118 Query: 189 QHLLPKMKAETNMVWYDWMRPSHAQLHSDYMQPLTEAKAKSKNKVRGVQQLIQRLRLIKS 248 + L+ +++ + V + +++ A K V + L +K Sbjct: 119 EDLVERVREAGSAVGLATKDSYQGKFITEWKGVWDTAVEKHGLNGVDVSLGLSSLWAVKD 178 Query: 249 PAEIERMQIAGKLTSQAFIETMFTSKAPVEE------AFLYAKFEFEC------------ 290 E +Q++ + + + V+E A L E E Sbjct: 179 EKEQAYLQVSSRGSDKFMNLLSDELVRAVDEEIKITDAKLSDNVENEIDKSRFLKKLSPE 238 Query: 291 ----RARGADIL------AYPPVVAGGNRSNT-LHYVKNNQLIKDGEMVLLDGGCESSCY 339 +G AY P++ G + + + + + +L G Y Sbjct: 239 LTPLCPKGEKFDVNYLDWAYSPIIQSGPKYDLRVSARSSETQLDGNGCILASCGIRYKNY 298 Query: 340 VSDITRTWPVNGRFTAPQAELYEAVLEIQRDCL-ALCFPGTSLENIYSMMLTLIGQKLKD 398 S+I+RT+ ++ + + Y+ +L +Q + + L G + + IY + I K + Sbjct: 299 CSNISRTFLID--PSDEMTDNYDFLLLLQEEIINNLLRVGATPKQIYDGAVNYINSKKPE 356 Query: 399 LGIMKNIKENNAFKAARKYCPHHVGHYLGMDVHDTPDM----PRSLPLQPGMVITIEPGI 454 L +VG +G++ D+ + ++ G I G Sbjct: 357 LSAG---------------FTKNVGSLMGLEFRDSQFVLNNKNDYRKVENGDCFNISLGF 401 Query: 455 YIPEDDKDAPEKFRGLGVRIEDDVVVTQDSPLILSA 490 +D K +++ D V +T P +L+ Sbjct: 402 NNLKDSKTGA----SYALQLADTVQLTSGGPKVLTN 433 >4B28-A nrPDB Length = 470 Score = 78.3 bits (191), Expect = 7e-15, Method: Composition-based stats. Identities = 60/362 (16%), Positives = 124/362 (34%), Gaps = 76/362 (20%) Query: 171 DGAIALTGVDEAYTLEEFQHLLPKMKAETNMVWYDWMRPSHAQLHSDYMQPLTE------ 224 DG + + + L EF L+ + +A ++ ++D R + +D Sbjct: 132 DGYMVMWDYKNSPFLSEFNPLVREQRAGADLFYFD--RGDKVDVAADVFANEVRILLRDH 189 Query: 225 ------------------AKAKSKNKVRGVQQLIQRLRLIKSPAEIERMQIAGKLTSQAF 266 A ++ +++ ++ R +K P EI M+ A A Sbjct: 190 APGLRRLAVDKVMLHGLRALQAQGFEIMDGEEVTEKARSVKGPDEIRAMRCASHACEVAV 249 Query: 267 IETMFTSKAPVE-----EAFLYAKFEFECRARGADILAYPPVVAGGNRSNTLHYVKNNQL 321 + +++ V E ++A E RG + + ++A G RSN ++ Sbjct: 250 RKMEDFARSKVGDGVTCENDIWAILHSENVRRGGEWIE-TRLLASGPRSNPWFQECGPRV 308 Query: 322 IKDGEMVLLD---GGCESSCYVSDITRTWPVNG-RFTAPQAELYEAVLEIQRDCLALCFP 377 + E++ D G +DI+R+W + + A + +E R + + P Sbjct: 309 CQRNEIISFDTDLVGAY--GICTDISRSWWIGDQKPRADMIYAMQHGVEHIRTNMEMLKP 366 Query: 378 GTSLENIYSMMLTLIGQKLKDLGIMKNIKENNAFKAARKYCPHHVGHYLGMDVHDTP--D 435 G + + + L + + H +G+ + P Sbjct: 367 GVMIPELSANTHVLDAK--------------FQKQKYGCLM-----HGVGL-CDEWPLVA 406 Query: 436 MPR-------SLPLQPGMVITIEPGIYIPEDDKDAPEKFRGLGVRIEDDVVVTQDSPLIL 488 P PL+PGM + +E E+ +++ED V++T+D L Sbjct: 407 YPDHAVAGAYDYPLEPGMTLCVE---------ALISEEGGDFSIKLEDQVLITEDGYENL 457 Query: 489 SA 490 + Sbjct: 458 TK 459 >3BIQ-A nrPDB Length = 467 Score = 70.2 bits (170), Expect = 2e-12, Method: Composition-based stats. Identities = 64/462 (13%), Positives = 154/462 (33%), Gaps = 84/462 (18%) Query: 70 VEYALRRHKLMSLIQKEAQGQSGTDQTVVVLSNPTYYMSNDIPYTFHQDNNFL-YLCGFQ 128 +++ + + ++ L K + + + + VL S++ + + +L ++ Sbjct: 8 IDFDVFKKRIELLYSKYNEFEGSPNSLLFVLG------SSNAENPYQKTTILHNWLLSYE 61 Query: 129 EPDS---------ILVLQSLPGKQLPSHKAILFVPRRDPSRELWDGPRSGTDGAIALTGV 179 P + I++ S K L + P + ELW R+ + + Sbjct: 62 FPATLIALVPGKVIIITSSAKAKHLQKAIDLFKDPESKITLELW--QRNNKEPELNKKLF 119 Query: 180 DEAYTLEEFQHLLPKMKAETNMVWYDWMRPSHAQLHSDYMQPLTEAKAKSKNKVRGVQQL 239 D+ L + + D + +++ A +++ V + Sbjct: 120 DDVIALINSAGKTVGIPEK------DSYQGKFM---TEWNPVWEAAVKENEFNVIDISLG 170 Query: 240 IQRLRLIKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEE------AFLYAKFE------ 287 + ++ +K E + ++ K + + V+E A L K E Sbjct: 171 LSKVWEVKDVNEQAFLSVSSKGSDKFMDLLSNEMVRAVDEELKITNAKLSDKIENKIDDV 230 Query: 288 -----------------FECRARGADILAYPPVVAGGNRSNT-LHYVKNNQLIKDGEMVL 329 ++ D Y P++ G + + + N + +L Sbjct: 231 KFLKQLSPDLSALCPPNYKFNFDLLDW-TYSPIIQSGKKFDLRVSARSTNDQLYGNGCIL 289 Query: 330 LDGGCESSCYVSDITRTWPVNGRFTAPQAELYEAVLEIQRDCLA-LCFPGTSLENIYSMM 388 G + Y S+ITRT+ ++ + A Y+ +L +Q++ + + PG + + +Y + Sbjct: 290 ASCGIRYNNYCSNITRTFLID--PSEEMANNYDFLLTLQKEIVTNILKPGRTPKEVYESV 347 Query: 389 LTLIGQKLKDLGIMKNIKENNAFKAARKYCPHHVGHYLGMDVHDTPDM----PRSLPLQP 444 + I + +L ++G +G++ D+ + +Q Sbjct: 348 IEYIEKTKPELV---------------PNFTKNIGSLIGLEFRDSNFILNVKNDYRKIQR 392 Query: 445 GMVITIEPGIYIPEDDKDAPEKFRGLGVRIEDDVVVTQDSPL 486 G I G +D + A +++ D V + D Sbjct: 393 GDCFNISFGFNNLKDSQSA----NNYALQLADTVQIPLDETE 430 >5LYW-A nrPDB Length = 378 Score = 66.0 bits (159), Expect = 4e-11, Method: Composition-based stats. Identities = 34/209 (16%), Positives = 66/209 (31%), Gaps = 27/209 (12%) Query: 256 QIAGKLTSQAFIETMFTSKAPVEEAFLYAKFE----FECRARGAD-ILAYPPVVAGGNRS 310 + A + Q M K + + K E + G + LA+P + Sbjct: 64 REAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPT--GCSLNN 121 Query: 311 NTLHYVKN---NQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGRFTAPQAELYEAVLEI 367 HY N +++ ++ +D G S + D T F L +AV + Sbjct: 122 CAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTV----TFNPKYDTLLKAVKDA 177 Query: 368 QRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMKNIKENNAFKAARKYCPHHVGHYLG 427 + L ++ + ++ ++ + K R H +G Y Sbjct: 178 TNTGIKCAGIDVRLCDVGEAIQEVMESYEVEI-----DGKTYQVKPIRNLNGHSIGQY-- 230 Query: 428 MDVHDTPDMP-----RSLPLQPGMVITIE 451 +H +P + ++ G V IE Sbjct: 231 -RIHAGKTVPIVKGGEATRMEEGEVYAIE 258 >1QZY-A nrPDB Length = 478 Score = 65.6 bits (158), Expect = 5e-11, Method: Composition-based stats. Identities = 34/209 (16%), Positives = 66/209 (31%), Gaps = 27/209 (12%) Query: 256 QIAGKLTSQAFIETMFTSKAPVEEAFLYAKFE----FECRARGAD-ILAYPPVVAGGNRS 310 + A + Q M K + + K E + G + LA+P + Sbjct: 170 REAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPT--GCSLNN 227 Query: 311 NTLHYVKN---NQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGRFTAPQAELYEAVLEI 367 HY N +++ ++ +D G S + D T F L +AV + Sbjct: 228 CAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTV----TFNPKYDTLLKAVKDA 283 Query: 368 QRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMKNIKENNAFKAARKYCPHHVGHYLG 427 + L ++ + ++ ++ + K R H +G Y Sbjct: 284 TNTGIKCAGIDVRLCDVGEAIQEVMESYEVEI-----DGKTYQVKPIRNLNGHSIGQY-- 336 Query: 428 MDVHDTPDMP-----RSLPLQPGMVITIE 451 +H +P + ++ G V IE Sbjct: 337 -RIHAGKTVPIIKGGEATRMEEGEVYAIE 364 >2Q8K-A nrPDB Length = 401 Score = 57.5 bits (137), Expect = 2e-08, Method: Composition-based stats. Identities = 19/154 (12%), Positives = 55/154 (35%), Gaps = 20/154 (12%) Query: 252 IERMQIAGKLTSQAFIETMFT----------SKAPVEEAFLYAKFEFECRARGADILAYP 301 + + ++ G + ++ + + F+ +A+P Sbjct: 25 VTKYKMGGDIANRVLRSLVEASSSGVSVLSLCEKGDAMIMEETGKIFKKEKEMKKGIAFP 84 Query: 302 PVVAGGNRSNTLHYVK----NNQLIKDGEMVLLDGGCESSCYVSDITRTWPVN----GRF 353 ++ + H+ + ++K+G++V +D G +++++ T+ V+ + Sbjct: 85 TSISV--NNCVCHFSPLKSDQDYILKEGDLVKIDLGVHVDGFIANVAHTFVVDVAQGTQV 142 Query: 354 TAPQAELYEAVLEIQRDCLALCFPGTSLENIYSM 387 T +A++ +A L L PG + Sbjct: 143 TGRKADVIKAAHLCAEAALRLVKPGNQNTQVTEA 176 >2V6C-A nrPDB Length = 353 Score = 56.7 bits (135), Expect = 2e-08, Method: Composition-based stats. Identities = 18/154 (11%), Positives = 54/154 (35%), Gaps = 20/154 (12%) Query: 252 IERMQIAGKLTSQAFIETMFT----------SKAPVEEAFLYAKFEFECRARGADILAYP 301 + + ++ G + ++ + + F+ +A+P Sbjct: 11 VTKYKMGGDIANRVLRSLVEASSSGVSVLSLCEKGDAMIMEETGKIFKKEKEMKKGIAFP 70 Query: 302 PVVAGGNRSNTLHYVK----NNQLIKDGEMVLLDGGCESSCYVSDITRTWPV----NGRF 353 ++ + H+ + ++K+G++V +D G +++++ T+ + + Sbjct: 71 TSISV--NNCVCHFSPLKSDQDYILKEGDLVKIDLGVHVDGFIANVAHTFVIGVAQGTQV 128 Query: 354 TAPQAELYEAVLEIQRDCLALCFPGTSLENIYSM 387 T +A++ +A L L PG + Sbjct: 129 TGRKADVIKAAHLCAEAALRLVKPGNQNTQVTEA 162 >3FMR-A nrPDB Length = 358 Score = 40.5 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 18/136 (13%), Positives = 41/136 (30%), Gaps = 14/136 (10%) Query: 273 SKAPVEEAFLYAKFE----FECRARGADILAYPPVVAGGNRSNTLHYVKN----NQLIKD 324 + + + E + + + +P S HY N + ++K+ Sbjct: 66 VRPGITLLEIVRSIEDSTRTLLKGERNNGIGFPA--GMSMNSCAAHYTVNPGEQDIVLKE 123 Query: 325 GEMVLLDGGCESSCYVSDITRTWPVNGRFTAPQAELYEAVLEIQRDCLALCFPGTSLENI 384 +++ +D G S + D T L A E + + +I Sbjct: 124 DDVLKIDFGTHSDGRIMDSAFTVAFKENLEP----LLVAAREGTETGIKSLGVDVRVCDI 179 Query: 385 YSMMLTLIGQKLKDLG 400 + +I ++G Sbjct: 180 GRDINEVISSYEVEIG 195 >1VHV-A nrPDB Length = 268 Score = 32.5 bits (72), Expect = 0.46, Method: Composition-based stats. Identities = 19/96 (19%), Positives = 34/96 (35%), Gaps = 1/96 (1%) Query: 162 LWDGPRSGTDGAIALTGVDEAYTLEEFQHLLPKMKAETNMVWYDWMRPSHAQLHSDYMQP 221 LWD G A+ DE Y LL ++ + + L + + Sbjct: 22 LWDVKDISVKGLEAVREADEVYVEYYTSKLLSSIEEMEEFFGKRVVELERSDLEENSFRL 81 Query: 222 LTEAKAKSKNKVRGVQQLIQ-RLRLIKSPAEIERMQ 256 + AK+KS + ++ IK AE + ++ Sbjct: 82 IERAKSKSVVLLVPGDPMVATTHSAIKLEAERKGVK 117 >1CHD-A nrPDB Length = 203 Score = 31.7 bits (70), Expect = 0.77, Method: Composition-based stats. Identities = 29/143 (20%), Positives = 49/143 (34%), Gaps = 21/143 (14%) Query: 44 RYLGQPSPFTHPHLLRPGEVTPGLSQVEYALRRHKLMSLIQKEAQGQSGTDQTVVVLSNP 103 R++ QP P + P ++ + PG ++ +A R +KL + KEA+ VL Sbjct: 26 RHVLQPLPLSSPAVIITQHMPPGFTR-SFAERLNKLCQISVKEAEDGER------VLPGH 78 Query: 104 TYYMSNDIPYTF-HQDNNFLYLCGFQEPDSILVLQSLPGKQLPSHKAILFVPRRDPSREL 162 Y D N+ I + P + +LF + Sbjct: 79 AYIAPGDKHMELARSGANYQ----------IKIHDGPPVNRHRPSVDVLFHSVAKHAGRN 128 Query: 163 WDGPRS---GTDGAIALTGVDEA 182 G G DGA + + +A Sbjct: 129 AVGVILTGMGNDGAAGMLAMYQA 151 >1A2O-A nrPDB Length = 349 Score = 31.7 bits (70), Expect = 0.88, Method: Composition-based stats. Identities = 29/143 (20%), Positives = 49/143 (34%), Gaps = 21/143 (14%) Query: 44 RYLGQPSPFTHPHLLRPGEVTPGLSQVEYALRRHKLMSLIQKEAQGQSGTDQTVVVLSNP 103 R++ QP P + P ++ + PG ++ +A R +KL + KEA+ VL Sbjct: 172 RHVLQPLPLSSPAVIITQHMPPGFTR-SFAERLNKLCQISVKEAEDGER------VLPGH 224 Query: 104 TYYMSNDIPYTF-HQDNNFLYLCGFQEPDSILVLQSLPGKQLPSHKAILFVPRRDPSREL 162 Y D N+ I + P + +LF + Sbjct: 225 AYIAPGDKHMELARSGANYQ----------IKIHDGPPVNRHRPSVDVLFHSVAKHAGRN 274 Query: 163 WDGPRS---GTDGAIALTGVDEA 182 G G DGA + + +A Sbjct: 275 AVGVILTGMGNDGAAGMLAMYQA 297 >5YLZ-V nrPDB Length = 382 Score = 31.3 bits (69), Expect = 1.0, Method: Composition-based stats. Identities = 19/110 (17%), Positives = 39/110 (35%), Gaps = 8/110 (7%) Query: 154 PRRDPSRELWDGPRSGTDGAIALTGVDEAYTLEEFQHLLPKMKAE-------TNMVWYDW 206 RD S L G G +++ +++ L K T+ W Sbjct: 112 SVRD-SHSLSFCRNCGEAGHKEKDCMEKPRKMQKLVPDLNSQKNNGTVLVRATDDDWDSR 170 Query: 207 MRPSHAQLHSDYMQPLTEAKAKSKNKVRGVQQLIQRLRLIKSPAEIERMQ 256 + +Y + +++ + +NK++G + L + EIE M+ Sbjct: 171 KDRWYGYSGKEYNELISKWERDKRNKIKGKDKSQTDETLWDTDEEIELMK 220 >6F8L-G nrPDB Length = 913 Score = 30.5 bits (67), Expect = 1.6, Method: Composition-based stats. Identities = 18/45 (40%), Positives = 27/45 (60%), Gaps = 3/45 (6%) Query: 435 DMPRSLPLQPGMVITIEPGIYIPEDDKDAPEKFRGLGVRIEDDVV 479 +PR+ PL I +E G+ PED ++A +K R G R+ED +V Sbjct: 329 GLPRAKPLGE---ILVELGLARPEDVEEALQKQRRGGGRLEDTLV 370 >2DW2-A nrPDB Length = 419 Score = 30.5 bits (67), Expect = 1.7, Method: Composition-based stats. Identities = 11/40 (27%), Positives = 18/40 (45%), Gaps = 3/40 (7%) Query: 400 GIMKNIKENNAFKAARKYCPHHVGHYLGMDVHDTPDMPRS 439 GI+++ E N H +GH LG++ HD+ Sbjct: 125 GIIQDYSEINL--VVAVIMAHEMGHNLGIN-HDSGYCSCG 161 >1V0D-A nrPDB Length = 329 Score = 30.1 bits (66), Expect = 2.5, Method: Composition-based stats. Identities = 19/71 (26%), Positives = 30/71 (42%), Gaps = 3/71 (4%) Query: 324 DGEMVLLDGGCESSCYVSDITRTWPVNGRFTAPQAELYEAVLEIQRDCLALCFPGTSLEN 383 D E++LL G YVSDITR V F P A + +A + D A + Sbjct: 69 DAELLLLTAGETWHGYVSDITRFLSV---FNEPHAGVIQAARQQLSDEQAPLRQKLLADL 125 Query: 384 IYSMMLTLIGQ 394 ++ + + + Sbjct: 126 LHHVSQNITAE 136 >5APN-x nrPDB Length = 616 Score = 29.8 bits (65), Expect = 3.0, Method: Composition-based stats. Identities = 6/29 (20%), Positives = 15/29 (51%) Query: 321 LIKDGEMVLLDGGCESSCYVSDITRTWPV 349 ++ G++V + G Y S+++ T + Sbjct: 155 TLRPGDLVKITLGVHIDGYTSEVSHTMVI 183 >5FPN-A nrPDB Length = 640 Score = 29.0 bits (63), Expect = 4.9, Method: Composition-based stats. Identities = 18/106 (16%), Positives = 40/106 (37%), Gaps = 3/106 (2%) Query: 192 LPKMKAETNMVWYDWMRPSHAQLHSDYMQPLTEAKAKSKNKVRGVQQLIQRLRLIKSPAE 251 +P+++ ++ + + A + +T K + + +++Q KS E Sbjct: 475 VPQIEVTFDIDANGILNVTAADKSTGKENKITITNDKGRLSKDDIDRMVQEAERYKSEDE 534 Query: 252 IERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKFEFECRARGADI 297 R ++A K A + K VE+ L K + + + D Sbjct: 535 ANRDRVAAK---NALESYTYNIKQTVEDEKLRGKISEQDKNKILDK 577 >2QR4-A nrPDB Length = 587 Score = 29.0 bits (63), Expect = 5.1, Method: Composition-based stats. Identities = 23/135 (17%), Positives = 43/135 (31%), Gaps = 3/135 (2%) Query: 136 LQSLPGKQLPSHKAILFVPRRDPSRELWDGPRSGTDGAIALTGVDEAYTLEEFQHLLPKM 195 L G + F E G ++ G A P++ Sbjct: 429 LDGFKGTVFRQTQFAEFEHFMHTEDEK--GVPLTSEYLSDSYGKLNAKYYGPAVEEDPEI 486 Query: 196 KAETNMVWYDWMRPSHAQLHSDYMQPLTEAKAKSKNKVRGVQQLIQRLRLIKSPAEIERM 255 K E + + + + Q + + AK + ++ + L+ S +E M Sbjct: 487 KFEWSRIPHFYYNYYVFQYSTGFSAASALAKKILNQEPEALENYLAYLKAGNSDYPVEVM 546 Query: 256 QIAG-KLTSQAFIET 269 + AG +T A+IE Sbjct: 547 KKAGVDMTQAAYIED 561 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.310 0.124 0.322 Lambda K H 0.267 0.0382 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 17,990,779 Number of Sequences: 36641 Number of extensions: 698693 Number of successful extensions: 2245 Number of sequences better than 10.0: 58 Number of HSP's better than 10.0 without gapping: 68 Number of HSP's successfully gapped in prelim test: 35 Number of HSP's that attempted gapping in prelim test: 1899 Number of HSP's gapped (non-prelim): 109 length of query: 507 length of database: 10,336,785 effective HSP length: 101 effective length of query: 406 effective length of database: 6,636,044 effective search space: 2694233864 effective search space used: 2694233864 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.4 bits) S2: 61 (28.2 bits)