BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q9MAT5 (383 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 3R0Q-C nrPDB 786 0.0 6CU3-A nrPDB 202 2e-52 5DST-A nrPDB 201 6e-52 3Q7E-A nrPDB 199 1e-51 5LV5-A nrPDB 194 4e-50 5EGS-A nrPDB 194 4e-50 4RYL-A nrPDB 192 1e-49 1F3L-A nrPDB 187 5e-48 5IS8-A nrPDB 186 1e-47 4IKP-A nrPDB 186 1e-47 3B3J-A nrPDB 186 1e-47 5FUB-A nrPDB 186 1e-47 5JMQ-A nrPDB 181 5e-46 1G6Q-1 nrPDB 164 8e-41 4LWO-B nrPDB 106 1e-23 5EKU-A nrPDB 89 2e-18 4M36-A nrPDB 89 4e-18 3X0D-A nrPDB 64 2e-10 6OGN-A nrPDB 59 3e-09 4G56-A nrPDB 44 8e-05 5FA5-A nrPDB 43 3e-04 3LPM-A nrPDB 37 0.021 3DLC-A nrPDB 35 0.041 3AOX-A nrPDB 35 0.060 4PNE-A nrPDB 34 0.11 4QNV-A nrPDB 34 0.11 1WY7-A nrPDB 34 0.14 3CJR-A nrPDB 33 0.19 4HTF-A nrPDB 33 0.25 3P9N-A nrPDB 33 0.26 3DUW-A nrPDB 33 0.30 5Z9O-A nrPDB 32 0.39 4QPN-A nrPDB 32 0.52 1QO0-D nrPDB 32 0.54 2ESR-A nrPDB 31 0.77 3EGE-A nrPDB 31 1.2 1SDD-B nrPDB 30 1.3 5WP5-A nrPDB 30 1.4 4N17-A nrPDB 30 1.8 4KDR-A nrPDB 30 1.8 4KDC-A nrPDB 30 2.1 1KR5-A nrPDB 30 2.4 4OIW-A nrPDB 29 2.7 4KRG-A nrPDB 29 2.7 5EUY-A nrPDB 29 2.9 2AS0-A nrPDB 29 3.4 2VS1-A nrPDB 29 3.7 3OPN-A nrPDB 29 4.3 6F5Z-A nrPDB 28 5.3 4O29-A nrPDB 28 5.8 3CCF-A nrPDB 28 6.7 1VQ1-A nrPDB 28 7.8 6BQC-A nrPDB 28 8.8 3GRV-A nrPDB 28 9.1 3FYD-A nrPDB 28 9.2 >3R0Q-C nrPDB Length = 376 Score = 786 bits (2030), Expect = 0.0, Method: Compositional matrix adjust. Identities = 373/373 (100%), Positives = 373/373 (100%) Query: 11 GGRAAGTGGGGPSAPVDKEVDYAQYFCTYSFLYHQKDMLSDRVRMDAYFNAVFQNKHHFE 70 GGRAAGTGGGGPSAPVDKEVDYAQYFCTYSFLYHQKDMLSDRVRMDAYFNAVFQNKHHFE Sbjct: 4 GGRAAGTGGGGPSAPVDKEVDYAQYFCTYSFLYHQKDMLSDRVRMDAYFNAVFQNKHHFE 63 Query: 71 GKTVLDVGTGSGILAIWSAQAGARKVYAVEATKMADHARALVKANNLDHIVEVIEGSVED 130 GKTVLDVGTGSGILAIWSAQAGARKVYAVEATKMADHARALVKANNLDHIVEVIEGSVED Sbjct: 64 GKTVLDVGTGSGILAIWSAQAGARKVYAVEATKMADHARALVKANNLDHIVEVIEGSVED 123 Query: 131 ISLPEKVDVIISEWMGYFLLRESMFDSVISARDRWLKPTGVMYPSHARMWLAPIKSNIAD 190 ISLPEKVDVIISEWMGYFLLRESMFDSVISARDRWLKPTGVMYPSHARMWLAPIKSNIAD Sbjct: 124 ISLPEKVDVIISEWMGYFLLRESMFDSVISARDRWLKPTGVMYPSHARMWLAPIKSNIAD 183 Query: 191 RKRNDFDGAMADWHNFSDEIKSYYGVDMGVLTKPFAEEQEKYYIQTAMWNDLNPQQIIGT 250 RKRNDFDGAMADWHNFSDEIKSYYGVDMGVLTKPFAEEQEKYYIQTAMWNDLNPQQIIGT Sbjct: 184 RKRNDFDGAMADWHNFSDEIKSYYGVDMGVLTKPFAEEQEKYYIQTAMWNDLNPQQIIGT 243 Query: 251 PTIVKEMDCLTASVSEIEEVRSNVTSVINMEHTRLCGFGGWFDVQFSGRKEDPAQQEIEL 310 PTIVKEMDCLTASVSEIEEVRSNVTSVINMEHTRLCGFGGWFDVQFSGRKEDPAQQEIEL Sbjct: 244 PTIVKEMDCLTASVSEIEEVRSNVTSVINMEHTRLCGFGGWFDVQFSGRKEDPAQQEIEL 303 Query: 311 TTAPSEQHCTHWGQQVFIMSNPINVEEGDNLNLGLLMSRSKENHRLMEIELNCEIKEASG 370 TTAPSEQHCTHWGQQVFIMSNPINVEEGDNLNLGLLMSRSKENHRLMEIELNCEIKEASG Sbjct: 304 TTAPSEQHCTHWGQQVFIMSNPINVEEGDNLNLGLLMSRSKENHRLMEIELNCEIKEASG 363 Query: 371 NPKESFKKTYFIE 383 NPKESFKKTYFIE Sbjct: 364 NPKESFKKTYFIE 376 >6CU3-A nrPDB Length = 336 Score = 202 bits (514), Expect = 2e-52, Method: Compositional matrix adjust. Identities = 114/321 (35%), Positives = 181/321 (56%), Gaps = 33/321 (10%) Query: 46 KDMLSDRVRMDAYFNAVFQNKHHFEGKTVLDVGTGSGILAIWSAQAGARKVYAVEATKMA 105 ++ML D +R +AY NA+ QNKH F+ K VLD+G G+GIL +++A+AGA++V ++ + + Sbjct: 27 EEMLKDGIRTNAYKNAILQNKHLFKDKVVLDIGCGTGILCLFAAKAGAKRVIGIDMSDII 86 Query: 106 DHARALVKANNLDHIVEVIEGSVEDIS-LP---EKVDVIISEWMGYFLLRESMFDSVISA 161 D AR +V N H++E+I+G VEDI+ LP EKVD+IISEWMGYFLL ESM +V+SA Sbjct: 87 DKARQIVSDNGYSHVIELIKGKVEDIAQLPFGIEKVDIIISEWMGYFLLYESMLQTVLSA 146 Query: 162 RDRWLKPTGVMYPSHARMWLAPIKSNIADRKRNDFDGAMADWHNFSDEIKSYYGVDMGVL 221 RDRWL+P G ++P M++ I+ + R + DF W N YG + + Sbjct: 147 RDRWLRPGGYLFPDKCTMYICGIEDSEYKRDKIDF------WDNV-------YGFNFSAI 193 Query: 222 TKPFAEEQEKYYIQTAMWNDLNPQQIIGTPTIVKEMDCLTASVSEIEEVRSNVTSVINME 281 E ++++ QQII T + E+D T +++++ ++ + Sbjct: 194 KADALREPLVDFVES--------QQIITTQSKFLEIDLNTIQPEDLKQITTSFE--FTSQ 243 Query: 282 HTRLC-GFGGWFDVQFSGRKEDPAQQEIELTTAPSEQHCTHWGQQVFIMSNPINVEEGDN 340 + C F WFD FS P +E +T P + THW Q VF + N + ++ D Sbjct: 244 YQEYCQAFVAWFDCVFSRGPHKP----VEFSTGPFTEG-THWKQTVFYLENDLPLKPNDV 298 Query: 341 LNLGLLMSRSKENHRLMEIEL 361 + + +S++K NHR ++I + Sbjct: 299 IKGTITISQNKSNHRDLDISM 319 >5DST-A nrPDB Length = 332 Score = 201 bits (510), Expect = 6e-52, Method: Compositional matrix adjust. Identities = 111/336 (33%), Positives = 195/336 (58%), Gaps = 36/336 (10%) Query: 35 YFCTYSFLYHQKDMLSDRVRMDAYFNAVFQNKHHFEGKTVLDVGTGSGILAIWSAQAGAR 94 YF +Y+ ++ML D VR Y N+++ NKH F+ K VLDVG+G+GIL++++A+AGA+ Sbjct: 14 YFDSYAHFGIHEEMLKDEVRTLTYRNSMYHNKHVFKDKVVLDVGSGTGILSMFAAKAGAK 73 Query: 95 KVYAVEATKMADHARALVKANNLDHIVEVIEGSVEDISLP-EKVDVIISEWMGYFLLRES 153 KV+ +E + ++D++ ++KAN+LD+I+ + +G VE++ LP EKVD+IISEWMGY L ES Sbjct: 74 KVFGIECSSISDYSEKIIKANHLDNIITIFKGKVEEVELPVEKVDIIISEWMGYCLFYES 133 Query: 154 MFDSVISARDRWLKPTGVMYPSHARMWLAPIKSNIADRKRNDFDGAMADWHNFSDEIKSY 213 M ++VI ARD+WLKP G+M+P A +++ I+ DR+ DF + W N Sbjct: 134 MLNTVIFARDKWLKPGGLMFPDRAALYVVAIE----DRQYKDF--KIHWWENV------- 180 Query: 214 YGVDMGVLTKPFAEEQEKYYIQTAMWNDLNPQQIIGTPTIVKEMDCLTASVSEIEEVRSN 273 YG DM + +E + + ++P+Q++ ++KE+D T E+ + Sbjct: 181 YGFDMTCIRDVAMKE--------PLVDIVDPKQVVTNACLIKEVDIYTVKTEEL-----S 227 Query: 274 VTSVINMEHTR---LCGFGGWFDVQFSGRKEDPAQQEIELTTAPSEQHCTHWGQQVFIMS 330 TS ++ R + +F+++F+ +++ +TAP + THW Q VF + Sbjct: 228 FTSAFCLQIQRNDYVHALVTYFNIEFT-----KCHKKMGFSTAPDAPY-THWKQTVFYLE 281 Query: 331 NPINVEEGDNLNLGLLMSRSKENHRLMEIELNCEIK 366 + + V G+ + + M + +N R ++ ++ + K Sbjct: 282 DYLTVRRGEEIYGTISMKPNAKNVRDLDFTVDLDFK 317 >3Q7E-A nrPDB Length = 349 Score = 199 bits (507), Expect = 1e-51, Method: Compositional matrix adjust. Identities = 111/333 (33%), Positives = 191/333 (57%), Gaps = 30/333 (9%) Query: 35 YFCTYSFLYHQKDMLSDRVRMDAYFNAVFQNKHHFEGKTVLDVGTGSGILAIWSAQAGAR 94 YF +Y+ +++L D VR Y N++F N+H F+ K VLDVG+G+GIL +++A+AGAR Sbjct: 31 YFDSYAHFGIHEELLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGAR 90 Query: 95 KVYAVEATKMADHARALVKANNLDHIVEVIEGSVEDISLP-EKVDVIISEWMGYFLLRES 153 KV +E + ++D+A +VKAN LDH+V +I+G VE++ LP EKVD+IISEWMGY L ES Sbjct: 91 KVIGIECSSISDYAVKIVKANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYES 150 Query: 154 MFDSVISARDRWLKPTGVMYPSHARMWLAPIKSNIADRKRNDFDGAMADWHNFSDEIKSY 213 M ++V+ ARD+WL P G+++P A +++ I+ DR+ D+ + W N Sbjct: 151 MLNTVLHARDKWLAPDGLIFPDRATLYVTAIE----DRQYKDY--KIHWWENV------- 197 Query: 214 YGVDMGVLTKPFAEEQEKYYIQTAMWNDLNPQQIIGTPTIVKEMDCLTASVSEIEEVRSN 273 YG DM + K A I+ + + ++P+Q++ ++KE+D T V ++ Sbjct: 198 YGFDMSCI-KDVA-------IKEPLVDVVDPKQLVTNACLIKEVDIYTVKVEDLTFTSPF 249 Query: 274 VTSVINMEHTRLCGFGGWFDVQFSGRKEDPAQQEIELTTAPSEQHCTHWGQQVFIMSNPI 333 V ++ +F+++F+ + +T+P + THW Q VF M + + Sbjct: 250 CLQVKRNDYVH--ALVAYFNIEFTR-----CHKRTGFSTSPESPY-THWKQTVFYMEDYL 301 Query: 334 NVEEGDNLNLGLLMSRSKENHRLMEIELNCEIK 366 V+ G+ + + M + +N+R ++ ++ + K Sbjct: 302 TVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFK 334 >5LV5-A nrPDB Length = 403 Score = 194 bits (494), Expect = 4e-50, Method: Compositional matrix adjust. Identities = 115/335 (34%), Positives = 186/335 (55%), Gaps = 24/335 (7%) Query: 35 YFCTYSFLYHQKDMLSDRVRMDAYFNAVFQNKHHFEGKTVLDVGTGSGILAIWSAQAGAR 94 Y+ YS + ++M++D+VR +AY + +N GKTVLDVG G+GIL+I+ AQAGAR Sbjct: 75 YYECYSDVSVHEEMIADQVRTEAYRLGILKNWAALRGKTVLDVGAGTGILSIFCAQAGAR 134 Query: 95 KVYAVEATKMADHARALVKANNLDHIVEVIEGSVEDISLPEKVDVIISEWMGYFLLRESM 154 +VYAVEA+ + AR +V+ N L+ V V+ G VE + LPE+VD I+SEWMGY LL ESM Sbjct: 135 RVYAVEASAIWQQAREVVRLNGLEDRVHVLPGPVETVELPERVDAIVSEWMGYGLLHESM 194 Query: 155 FDSVISARDRWLKPTGVMYPSHARMWLAPIKSNIADRKRNDFDGAMADWH-NFSDEIKSY 213 SV+ AR +WLK G++ P+ A +++API M +W F ++K + Sbjct: 195 LSSVLHARTKWLKEGGLLLPASAELFVAPISDQ------------MLEWRLGFWSQVKQH 242 Query: 214 YGVDMGVLTKPFAEEQEKYYIQTAMWNDLNPQQIIGTPTIVKEMDCLTASVSEIEEVRSN 273 YGVDM + + FA + + + DL+ + ++ P +++ A + +E+ + Sbjct: 243 YGVDMSCM-ESFATRCLMGHSEIVV-QDLSGEDVLARPQRFAQLELARAGLE--QELEAG 298 Query: 274 VTSVINME---HTRLCGFGGWFDVQFSGRKEDPAQQEIELTTAPSEQHCTHWGQQVFIMS 330 V L GF WF V F G +++ + L+T+P THW Q + ++ Sbjct: 299 VGGRFRCSCYGSAPLHGFAVWFQVTFPG---GDSEKPLVLSTSPLHP-ATHWKQALLYLN 354 Query: 331 NPINVEEGDNLNLGLLMSRSKENHRLMEIELNCEI 365 P+ VE+ +++ + + S +N R + I L ++ Sbjct: 355 EPVPVEQDTDISGEITLLPSPDNPRRLRILLRYKV 389 >5EGS-A nrPDB Length = 376 Score = 194 bits (494), Expect = 4e-50, Method: Compositional matrix adjust. Identities = 118/351 (33%), Positives = 192/351 (54%), Gaps = 25/351 (7%) Query: 28 KEVDYAQYFCTYSFLYHQKDMLSDRVRMDAYFNAVFQNKHHFEGKTVLDVGTGSGILAIW 87 +E D Y C YS + ++M++DRVR DAY + +N GKTVLDVG G+GIL+I+ Sbjct: 42 RERDQLYYEC-YSDVSVHEEMIADRVRTDAYRLGILRNWAALRGKTVLDVGAGTGILSIF 100 Query: 88 SAQAGARKVYAVEATKMADHARALVKANNLDHIVEVIEGSVEDISLPEKVDVIISEWMGY 147 AQAGAR+VYAVEA+ + AR +V+ N L+ V V+ G VE + LPE+VD I+SEWMGY Sbjct: 101 CAQAGARRVYAVEASAIWQQAREVVRFNGLEDRVHVLPGPVETVELPEQVDAIVSEWMGY 160 Query: 148 FLLRESMFDSVISARDRWLKPTGVMYPSHARMWLAPIKSNIADRKRNDFDGAMADWH-NF 206 LL ESM SV+ AR +WLK G++ P+ A +++ PI M +W F Sbjct: 161 GLLHESMLSSVLHARTKWLKEGGLLLPASAELFIVPISDQ------------MLEWRLGF 208 Query: 207 SDEIKSYYGVDMGVLTKPFAEEQEKYYIQTAMWNDLNPQQIIGTPTIVKEMDCLTASVSE 266 ++K +YGVDM L + FA + + + L+ + ++ P +++ A + Sbjct: 209 WSQVKQHYGVDMSCL-EGFATRCLMGHSEIVV-QGLSGEDVLARPQRFAQLELSRAGLE- 265 Query: 267 IEEVRSNVTSVINME---HTRLCGFGGWFDVQFSGRKEDPAQQEIELTTAPSEQHCTHWG 323 +E+ + V + GF WF V F G + +++ + L+T+P THW Sbjct: 266 -QELEAGVGGRFRCSCYGSAPMHGFAIWFQVTFPGGE---SEKPLVLSTSPF-HPATHWK 320 Query: 324 QQVFIMSNPINVEEGDNLNLGLLMSRSKENHRLMEIELNCEIKEASGNPKE 374 Q + ++ P+ VE+ +++ + + S++N R + + L ++ + K+ Sbjct: 321 QALLYLNEPVQVEQDTDVSGEITLLPSRDNPRRLRVLLRYKVGDQEEKTKD 371 >4RYL-A nrPDB Length = 340 Score = 192 bits (489), Expect = 1e-49, Method: Compositional matrix adjust. Identities = 111/330 (33%), Positives = 187/330 (56%), Gaps = 31/330 (9%) Query: 35 YFCTYSFLYHQKDMLSDRVRMDAYFNAVFQNKHHFEGKTVLDVGTGSGILAIWSAQAGAR 94 YF +Y ++ML D++R ++Y + ++QN H F+ K VLDVG G+GIL++++A+AGA+ Sbjct: 29 YFSSYGHYGIHEEMLKDKIRTESYRDFIYQNPHIFKDKVVLDVGCGTGILSMFAAKAGAK 88 Query: 95 KVYAVEATKMADHARALVKANNLDHIVEVIEGSVEDISLP-EKVDVIISEWMGYFLLRES 153 KV V+ +++ A +++ N L+ + +I+G +E++ LP EKVDVIISEWMGYFLL ES Sbjct: 89 KVLGVDQSEILYQAMDIIRLNKLEDTITLIKGKIEEVHLPVEKVDVIISEWMGYFLLFES 148 Query: 154 MFDSVISARDRWLKPTGVMYPSHARMWLAPIKSNIADRKRNDFDGAMADWHNFSDEIKSY 213 M DSV+ A++++L G +YP + L ++D ++ AD F D++ Sbjct: 149 MLDSVLYAKNKYLAKGGSVYPDICTISLVA----VSDVNKH------ADRIAFWDDV--- 195 Query: 214 YGVDMGVLTKPFAEEQEKYYIQTAMWNDLNPQQIIGTPTIVKEMDCLTASVSEIEEVRSN 273 YG M + K E A+ L+P+ +I P +K +DC T S+S++ E S+ Sbjct: 196 YGFKMSCMKKAVIPE--------AVVEVLDPKTLISEPCGIKHIDCHTTSISDL-EFSSD 246 Query: 274 VTSVINMEHTRLC-GFGGWFDVQFSGRKEDPAQQEIELTTAPSEQHCTHWGQQVFIMSNP 332 T + + T +C G+FD+ F E + +T P THW Q VF++ P Sbjct: 247 FT--LKITRTSMCTAIAGYFDIYF----EKNCHNRVVFSTGPQSTK-THWKQTVFLLEKP 299 Query: 333 INVEEGDNLNLGLLMSRSKENHRLMEIELN 362 +V+ G+ L + + ++K++ R + + L Sbjct: 300 FSVKAGEALKGKVTVHKNKKDPRSLTVTLT 329 >1F3L-A nrPDB Length = 321 Score = 187 bits (476), Expect = 5e-48, Method: Compositional matrix adjust. Identities = 112/332 (33%), Positives = 184/332 (55%), Gaps = 35/332 (10%) Query: 35 YFCTYSFLYHQKDMLSDRVRMDAYFNAVFQNKHHFEGKTVLDVGTGSGILAIWSAQAGAR 94 YF +Y ++ML D+VR ++Y + ++QN H F+ K VLDVG G+GIL++++A+AGA+ Sbjct: 10 YFSSYGHYGIHEEMLKDKVRTESYRDFIYQNPHIFKDKVVLDVGCGTGILSMFAAKAGAK 69 Query: 95 KVYAVEATKMADHARALVKANNLDHIVEVIEGSVEDISLP-EKVDVIISEWMGYFLLRES 153 KV AV+ +++ A +++ N L+ + +I+G +E++SLP EKVDVIISEWMGYFLL ES Sbjct: 70 KVIAVDQSEILYQAMDIIRLNKLEDTIVLIKGKIEEVSLPVEKVDVIISEWMGYFLLFES 129 Query: 154 MFDSVISARDRWLKPTGVMYPSHARMWLAPIK--SNIADRKRNDFDGAMADWHNFSDEIK 211 M DSV+ A+ ++L G +YP + L + S ADR +A W + Sbjct: 130 MLDSVLYAKSKYLAKGGSVYPDICTISLVAVSDVSKHADR--------IAFWDDV----- 176 Query: 212 SYYGVDMGVLTKPFAEEQEKYYIQTAMWNDLNPQQIIGTPTIVKEMDCLTASVSEIEEVR 271 YG +M + K E A+ ++ + +I P +K +DC T S+S++ E Sbjct: 177 --YGFNMSCMKKAVIPE--------AVVEVVDHKTLISDPCDIKHIDCHTTSISDL-EFS 225 Query: 272 SNVTSVINMEHTRLC-GFGGWFDVQFSGRKEDPAQQEIELTTAPSEQHCTHWGQQVFIMS 330 S+ T + T +C G+FD+ F E + +T P THW Q +F++ Sbjct: 226 SDFT--LRTTKTAMCTAVAGYFDIYF----EKNCHNRVVFSTGPQSTK-THWKQTIFLLE 278 Query: 331 NPINVEEGDNLNLGLLMSRSKENHRLMEIELN 362 P V+ G+ L + + ++K++ R + + L Sbjct: 279 KPFPVKAGEALKGKITVHKNKKDPRSLIVTLT 310 >5IS8-A nrPDB Length = 381 Score = 186 bits (473), Expect = 1e-47, Method: Compositional matrix adjust. Identities = 121/334 (36%), Positives = 185/334 (55%), Gaps = 30/334 (8%) Query: 28 KEVDYAQYFCTYSFLYHQKDMLSDRVRMDAYFNAVFQNKHHFEGKTVLDVGTGSGILAIW 87 +E QYF Y +L Q++M+ D VR Y A+ QN F+ K VLDVG GSGIL+ + Sbjct: 17 EESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSGILSFF 76 Query: 88 SAQAGARKVYAVEATKMADHARALVKANNLDHIVEVIEGSVEDISLPEKVDVIISEWMGY 147 +AQAGARK+YAVEA+ MA HA LVK+NNL + VI G VE++SLPE+VD+IISE MGY Sbjct: 77 AAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDIIISEPMGY 136 Query: 148 FLLRESMFDSVISARDRWLKPTGVMYPSHARMWLAPIKSN---IADRKRNDFDGAMADWH 204 L E M +S + A+ ++LKP+G M+P+ + LAP + + +F W+ Sbjct: 137 MLFNERMLESYLHAK-KYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANF------WY 189 Query: 205 NFSDEIKSYYGVDMGVLTKPFAEEQEKYYIQTAMWNDLNPQQIIGTPTIVKEMDCLTASV 264 S++GVD+ L +E Y+ Q + D +I+ ++ ++ L A Sbjct: 190 Q-----PSFHGVDLSALRGAAVDE---YFRQPVV--DTFDIRILMAKSVKYTVNFLEAKE 239 Query: 265 SEIEEVRSNVTSVINMEHTRLC-GFGGWFDVQFSGRKEDPAQQEIELTTAPSEQHCTHWG 323 ++ R + +M H+ L G WFDV F G + + L+TAP+E THW Sbjct: 240 GDLH--RIEIPFKFHMLHSGLVHGLAFWFDVAFIG-----SIMTVWLSTAPTEP-LTHWY 291 Query: 324 QQVFIMSNPINVEEGDNLN-LGLLMSRSKENHRL 356 Q + +P+ + GD L+ LL++ ++++ + Sbjct: 292 QVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDI 325 >4IKP-A nrPDB Length = 341 Score = 186 bits (473), Expect = 1e-47, Method: Compositional matrix adjust. Identities = 121/332 (36%), Positives = 184/332 (55%), Gaps = 30/332 (9%) Query: 28 KEVDYAQYFCTYSFLYHQKDMLSDRVRMDAYFNAVFQNKHHFEGKTVLDVGTGSGILAIW 87 +E QYF Y +L Q++M+ D VR Y A+ QN F+ K VLDVG GSGIL+ + Sbjct: 3 EESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSGILSFF 62 Query: 88 SAQAGARKVYAVEATKMADHARALVKANNLDHIVEVIEGSVEDISLPEKVDVIISEWMGY 147 +AQAGARK+YAVEA+ MA HA LVK+NNL + VI G VE++SLPE+VD+IISE MGY Sbjct: 63 AAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDIIISEPMGY 122 Query: 148 FLLRESMFDSVISARDRWLKPTGVMYPSHARMWLAPIKSN---IADRKRNDFDGAMADWH 204 L E M +S + A+ ++LKP+G M+P+ + LAP + + +F W+ Sbjct: 123 MLFNERMLESYLHAK-KYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANF------WY 175 Query: 205 NFSDEIKSYYGVDMGVLTKPFAEEQEKYYIQTAMWNDLNPQQIIGTPTIVKEMDCLTASV 264 S++GVD+ L +E Y+ Q + D +I+ ++ ++ L A Sbjct: 176 Q-----PSFHGVDLSALRGAAVDE---YFRQPVV--DTFDIRILMAKSVKYTVNFLEAKE 225 Query: 265 SEIEEVRSNVTSVINMEHTRLC-GFGGWFDVQFSGRKEDPAQQEIELTTAPSEQHCTHWG 323 ++ R + +M H+ L G WFDV F G + + L+TAP+E THW Sbjct: 226 GDLH--RIEIPFKFHMLHSGLVHGLAFWFDVAFIG-----SIMTVWLSTAPTEP-LTHWY 277 Query: 324 QQVFIMSNPINVEEGDNLN-LGLLMSRSKENH 354 Q + +P+ + GD L+ LL++ ++++ Sbjct: 278 QVRCLFQSPLFAKAGDTLSGTCLLIANKRQSY 309 >3B3J-A nrPDB Length = 480 Score = 186 bits (473), Expect = 1e-47, Method: Compositional matrix adjust. Identities = 121/332 (36%), Positives = 184/332 (55%), Gaps = 30/332 (9%) Query: 28 KEVDYAQYFCTYSFLYHQKDMLSDRVRMDAYFNAVFQNKHHFEGKTVLDVGTGSGILAIW 87 +E QYF Y +L Q++M+ D VR Y A+ QN F+ K VLDVG GSGIL+ + Sbjct: 116 EESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSGILSFF 175 Query: 88 SAQAGARKVYAVEATKMADHARALVKANNLDHIVEVIEGSVEDISLPEKVDVIISEWMGY 147 +AQAGARK+YAVEA+ MA HA LVK+NNL + VI G VE++SLPE+VD+IISE MGY Sbjct: 176 AAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDIIISEPMGY 235 Query: 148 FLLRESMFDSVISARDRWLKPTGVMYPSHARMWLAPIKSN---IADRKRNDFDGAMADWH 204 L E M +S + A+ ++LKP+G M+P+ + LAP + + +F W+ Sbjct: 236 MLFNERMLESYLHAK-KYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANF------WY 288 Query: 205 NFSDEIKSYYGVDMGVLTKPFAEEQEKYYIQTAMWNDLNPQQIIGTPTIVKEMDCLTASV 264 S++GVD+ L +E Y+ Q + D +I+ ++ ++ L A Sbjct: 289 Q-----PSFHGVDLSALRGAAVDE---YFRQPVV--DTFDIRILMAKSVKYTVNFLEAKE 338 Query: 265 SEIEEVRSNVTSVINMEHTRLC-GFGGWFDVQFSGRKEDPAQQEIELTTAPSEQHCTHWG 323 ++ R + +M H+ L G WFDV F G + + L+TAP+E THW Sbjct: 339 GDLH--RIEIPFKFHMLHSGLVHGLAFWFDVAFIG-----SIMTVWLSTAPTEP-LTHWY 390 Query: 324 QQVFIMSNPINVEEGDNLN-LGLLMSRSKENH 354 Q + +P+ + GD L+ LL++ ++++ Sbjct: 391 QVRCLFQSPLFAKAGDTLSGTCLLIANKRQSY 422 >5FUB-A nrPDB Length = 337 Score = 186 bits (473), Expect = 1e-47, Method: Compositional matrix adjust. Identities = 114/330 (34%), Positives = 175/330 (53%), Gaps = 27/330 (8%) Query: 34 QYFCTYSFLYHQKDMLSDRVRMDAYFNAVFQNKHHFEGKTVLDVGTGSGILAIWSAQ-AG 92 +YF Y L +MLSD+ R + Y + N K VLD+G G+G+++++ A A Sbjct: 8 EYFGNYGTLRLHLEMLSDKPRTETYRQVILSNSAALREKVVLDLGCGTGVISLFCALLAK 67 Query: 93 ARKVYAVEATKMADHARALVKANNLDHIVEVIEGSVEDISLPEKVDVIISEWMGYFLLRE 152 VYAVEA+ MA+H LVK N D +V V + E+++LP KVDV++SEWMG LL E Sbjct: 68 PAGVYAVEASSMAEHTEELVKQNGCDGVVTVFQERAENLTLPTKVDVLVSEWMGNCLLFE 127 Query: 153 SMFDSVISARDRWLKPTGVMYPSHARMWLAPIKSNIADRKRNDFDGAMADWHNFSDEIKS 212 M +SV+ ARDRWLK G+M+PS A + + P ++ R++ +F W N Sbjct: 128 YMLESVLLARDRWLKKGGMMWPSSACLTIVPCQAFSDYRQKVEF------WEN------- 174 Query: 213 YYGVDMGVLTKPFAEEQEKYYIQTAMWNDLNPQQIIGTPTIVKEMDCLTASVSEIEEVRS 272 YG++ L + Q+++ + + L P+ + TP V +D +T VS++E ++ Sbjct: 175 PYGLNFSYLQ---SLAQKEFLSKPKFSHHLQPEDCLSTPADVITLDMVTIQVSDLERLKG 231 Query: 273 NVTSVIN---MEHTRLCGFGGWFDVQFSGRKEDPAQQEIELTTAPSEQHCTHWGQQVFIM 329 T + M H GF WF F +ED IEL T P + THW Q +F++ Sbjct: 232 EFTFTVEKSGMFH----GFTVWFSAHFQCLEEDGPS--IELNTGPYSE-ITHWKQTLFML 284 Query: 330 SNPINVEEGDNLNLGLLMSRSKENHRLMEI 359 P++VEEGD + + + R+ R + I Sbjct: 285 DAPVSVEEGDIIAGSIRLQRNPIWRRHLSI 314 >5JMQ-A nrPDB Length = 446 Score = 181 bits (459), Expect = 5e-46, Method: Compositional matrix adjust. Identities = 116/367 (31%), Positives = 183/367 (49%), Gaps = 30/367 (8%) Query: 12 GRAAGTGGGGPSAPVDKEVDY---------AQYFCTYSFLYHQKDMLSDRVRMDAYFNAV 62 G AG G P+ + K+++ +YF +Y L +ML+D+ R Y + + Sbjct: 83 GERAGCCGYIPANHLGKQLEEYDPEDTWQDEEYFDSYGTLKLHLEMLADQPRTTKYHSVI 142 Query: 63 FQNKHHFEGKTVLDVGTGSGILAIWSAQ-AGARKVYAVEATKMADHARALVKANNLDHIV 121 QNK + K +LDVG G+GI++++ A A + VYAVEA+ MA H LV N + Sbjct: 143 LQNKESLKDKVILDVGCGTGIISLFCAHHARPKAVYAVEASDMAQHTSQLVLQNGFADTI 202 Query: 122 EVIEGSVEDISLPEKVDVIISEWMGYFLLRESMFDSVISARDRWLKPTGVMYPSHARMWL 181 V + VED+ LPEKVDV++SEWMG LL E M +S++ ARD WLK G+++P+ A + L Sbjct: 203 TVFQQKVEDVVLPEKVDVLVSEWMGTCLLFEFMIESILYARDTWLKGDGIIWPTTAALHL 262 Query: 182 APIKSNIADRKRNDFDGAMADWHNFSDEIKSYYGVDMGVLTKPFAEEQEKYYIQTAMWND 241 P + D+ + W N Y ++ L +E ++ + + Sbjct: 263 VPCSAE------KDYHSKVLFWDN-------AYEFNLSALKSLAIKE---FFSRPKSNHI 306 Query: 242 LNPQQIIGTPTIVKEMDCLTASVSEIEEVRSNVTSVINMEHTRLCGFGGWFDVQFSGRKE 301 L P+ + P + ++D T V ++E +R + I T L GF WF V F +E Sbjct: 307 LKPEDCLSEPCTILQLDMRTVQVPDLETMRGELRFDIQKAGT-LHGFTAWFSVYFQSLEE 365 Query: 302 DPAQQEIELTTAPSEQHCTHWGQQVFIMSNPINVEEGDNLNLGLLMSRSKENHRLMEIEL 361 QQ L+T P THW Q +F+M +P+ V GD + +++ R+ R M + L Sbjct: 366 GQPQQ--VLSTGPLHP-TTHWKQTLFMMDDPVPVHTGDVVTGSVVLQRNPVWRRHMSVSL 422 Query: 362 NCEIKEA 368 + + A Sbjct: 423 SWVVTSA 429 >1G6Q-1 nrPDB Length = 328 Score = 164 bits (414), Expect = 8e-41, Method: Compositional matrix adjust. Identities = 110/343 (32%), Positives = 179/343 (52%), Gaps = 41/343 (11%) Query: 35 YFCTYSFLYHQKDMLSDRVRMDAYFNAVFQNKHHFEGKTVLDVGTGSGILAIWSAQAGAR 94 YF +Y ++ML D VR +Y NA+ QNK F+ K VLDVG G+GIL++++A+ GA+ Sbjct: 3 YFDSYDHYGIHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAK 62 Query: 95 KVYAVEATKMADHARALVKANNLDHIVEVIEGSVEDISLP-EKVDVIISEWMGYFLLRES 153 V V+ + + + A+ LV+ N + ++ G +ED+ LP KVD+IISEWMGYFLL ES Sbjct: 63 HVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLEDVHLPFPKVDIIISEWMGYFLLYES 122 Query: 154 MFDSVISARDRWLKPTGVMYPSHARMWLAPIK-SNIADRKRNDFDGAMADWHNFSDEIKS 212 M D+V+ ARD +L G+++P + LA ++ S D K N W + Sbjct: 123 MMDTVLYARDHYLVEGGLIFPDKCSIHLAGLEDSQYKDEKLN-------YWQDV------ 169 Query: 213 YYGVDMG-----VLTKPFAEEQEKYYIQTAMWNDLNPQQIIGTPTIVKEMDCLTASVSEI 267 YG D VL +P + E+ + T T + E D T +S++ Sbjct: 170 -YGFDYSPFVPLVLHEPIVDTVERNNVNT-------------TSDKLIEFDLNTVKISDL 215 Query: 268 EEVRSNVTSVINMEHTRLCGFGGWFDVQFSGRKEDPAQQEIELTTAPSEQHCTHWGQQVF 327 +SN + + G WFD+ F K ++ +E +T P + THW Q +F Sbjct: 216 -AFKSNF-KLTAKRQDMINGIVTWFDIVFPAPK---GKRPVEFSTGPHAPY-THWKQTIF 269 Query: 328 IMSNPINVEEGDNLNLGLLMSRSKENHRLMEIELNCEIKEASG 370 + ++ E GD + L+ S +++N+R + I+++ + E++G Sbjct: 270 YFPDDLDAETGDTIEGELVCSPNEKNNRDLNIKISYKF-ESNG 311 >4LWO-B nrPDB Length = 368 Score = 106 bits (265), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 106/385 (27%), Positives = 172/385 (44%), Gaps = 89/385 (23%) Query: 34 QYFCTYSFLYHQKDMLSDRVRMDAYFNAVFQNKHHFEGKTVLDVGTGSGILAIWSAQAGA 93 QY+ +YS L + ML D RM Y ++ Q+ EGK V+DVG+G+GIL++W+A+AGA Sbjct: 19 QYYESYSDLAVHRLMLEDAQRMSFYRKSIEQSAS-IEGKVVVDVGSGTGILSMWAARAGA 77 Query: 94 RKVYAVEATKMADHARALVKANNL--------DHIVEVIEGSVEDISLPEK-------VD 138 + V+++EA+ +++ +V+ N+L D + +I G V + K V Sbjct: 78 KHVFSIEASSLSEFQIGVVEDNDLSTKITVLGDTVENIIAGGVANFVNRHKAKLGKCGVA 137 Query: 139 VIISEWMGYFLLRESMFDSVISARDRW---------LKPTGVMYPSHARMWLAPI--KSN 187 V++SEWMG++L E M SVI AR+ + L+P M P A +++API K Sbjct: 138 VLLSEWMGFYLFHEGMLPSVIRARNFFQDVNAALGVLQPIE-MIPERATVFVAPITCKPY 196 Query: 188 IADRKRN---DFDGAMADWHNFSDEIKSYYGVDMGVLTKPFAEEQEKYYIQTAMWNDLNP 244 R +N D DG +FS + Y V + EQ ++ L P Sbjct: 197 YVQRYKNFWRDVDGL-----DFSRYGRIEYEVYL---------EQASPLVEC-----LPP 237 Query: 245 QQIIGTPTIVKEMDCLTASVSEIEEVRSNVTSVINM---------EHTR---------LC 286 ++ + E++ T EEV +++ + ++ +H R + Sbjct: 238 LCLLHEGLSLIELNLSTVQ----EEVLTSLHNTVHFDLKESAEFQQHAREAGSEGRVSVD 293 Query: 287 GFGGWFDVQFSGRKEDPAQQEIELTTAPSEQHCTHWGQQVFIMSNPINVE-------EGD 339 GF WFDV + L+T+P THW Q ++ E EG Sbjct: 294 GFTVWFDVSYGAHT---------LSTSPRSP-STHWKQTTILLPREARNEELVSFPVEGG 343 Query: 340 NLNLGLLMSRSKENHRLMEIELNCE 364 L + + +S S + R IEL + Sbjct: 344 ELGVEMHISASDKTLRFYTIELELK 368 >5EKU-A nrPDB Length = 390 Score = 89.4 bits (220), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 53/149 (35%), Positives = 87/149 (58%), Gaps = 8/149 (5%) Query: 48 MLSDRVRMDAYFNAVFQNKHHFEGKT-VLDVGTGSGILAIWSAQAGARKVYAVEATK-MA 105 M++D R + Y+ + K H +T VL++G GSG+L++ +A+ GA+ V AVE ++ +A Sbjct: 75 MMNDEERNNFYYEVL---KKHVTPETGVLEIGAGSGLLSLMAAKLGAKWVVAVEGSEELA 131 Query: 106 DHARALVKANNLDHIVEVIEGSVEDIS---LPEKVDVIISEWMGYFLLRESMFDSVISAR 162 AR ++ANN++H V+V+ ++ LPE DV++SE G +L ES D V+ R Sbjct: 132 KLARENIRANNMEHQVKVLHMMSTELKPKHLPEPPDVLLSEIFGTMMLGESALDYVVDVR 191 Query: 163 DRWLKPTGVMYPSHARMWLAPIKSNIADR 191 +R LKPT + P + PI+ + R Sbjct: 192 NRLLKPTTKIIPQFGTQYAVPIECDALHR 220 >4M36-A nrPDB Length = 343 Score = 88.6 bits (218), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 52/148 (35%), Positives = 85/148 (57%), Gaps = 6/148 (4%) Query: 48 MLSDRVRMDAYFNAVFQNKHHFEGKTVLDVGTGSGILAIWSAQAGARKVYAVEATK-MAD 106 M++D R + Y+ + KH VL++G GSG+L++ +A+ GA+ V AVE ++ +A Sbjct: 40 MMNDEERNNFYYEVL--KKHVTPETGVLEIGAGSGLLSLMAAKLGAKWVVAVEGSEELAK 97 Query: 107 HARALVKANNLDHIVEVIEGSVEDIS---LPEKVDVIISEWMGYFLLRESMFDSVISARD 163 AR ++ANN++H V+V+ ++ LPE DV++SE G +L ES D V+ R+ Sbjct: 98 LARENIRANNMEHQVKVLHMMSTELKSKHLPEPPDVLLSEIFGTMMLGESALDYVVDVRN 157 Query: 164 RWLKPTGVMYPSHARMWLAPIKSNIADR 191 R LKPT + P + PI+ + R Sbjct: 158 RLLKPTTKIIPQFGTQYAVPIECDALHR 185 >3X0D-A nrPDB Length = 655 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 50/171 (29%), Positives = 86/171 (50%), Gaps = 13/171 (7%) Query: 27 DKEVDYAQYFCTYSFLYHQKDMLSDRVRMDAYF----NAVFQNKH-HFEGKT-VLDVGTG 80 +++ D AQ F DM+ D R D + + + KH + +GK VLD+GTG Sbjct: 27 EEDYDMAQELARSRF----GDMILDFDRNDKFLAGLKTTIAEKKHENTDGKVHVLDIGTG 82 Query: 81 SGILAIWSAQAGARKVYAVEATK-MADHARALVKANNLDHIVEVIEGSVEDISL--PEKV 137 +G+L++ +A+ GA KV A+E K M D AR + + + VI D+S + Sbjct: 83 TGLLSLMAAREGADKVTALEVFKPMGDCARHITSNSPWSDKITVISERSTDVSQIGGSRA 142 Query: 138 DVIISEWMGYFLLRESMFDSVISARDRWLKPTGVMYPSHARMWLAPIKSNI 188 D+I++E L+ E + A +R KP + PS +++ P++S++ Sbjct: 143 DIIVAEVFDTELIGEGALRTFKEALERLAKPGCRVVPSTGNVYIVPVESHL 193 >6OGN-A nrPDB Length = 692 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 48/157 (30%), Positives = 75/157 (47%), Gaps = 15/157 (9%) Query: 12 GRAAGTGGGGPSAPVDKEVDYAQYFCTYSFLYHQKDMLSDRVRMDAYFN----AVFQNKH 67 GRA T G D+ DY Q S+ DML D+ R Y+ AV + K Sbjct: 6 GRANPTTGSLEWLEEDEHYDYHQEIARSSY----ADMLHDKDRNIKYYQGIRAAVSRVKD 61 Query: 68 HFEGKTVLDVGTGSGILAIWSAQAGARKVYAVEATK-MADHARALVKANNLDHIVEVIEG 126 + VLD+GTG+G+L++ + AGA YA+E K MA+ A +V+ N ++VI Sbjct: 62 RGQKALVLDIGTGTGLLSMMAVTAGADFCYAIEVFKPMAEAAVKIVERNGFSDKIKVINK 121 Query: 127 SVEDIS------LPEKVDVIISEWMGYFLLRESMFDS 157 +++ LP + +++I+E L+ E S Sbjct: 122 HSTEVTVGPDGDLPCRANILITELFDTELIGEGALPS 158 >4G56-A nrPDB Length = 657 Score = 44.3 bits (103), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 36/121 (29%), Positives = 54/121 (44%), Gaps = 6/121 (4%) Query: 72 KTVLDVGTGSGILAIWSAQAGAR-----KVYAVEATKMADHARALVKANNLDHIVEVIEG 126 + ++ +G G G L S +A + KVYAVE A + V V+ G Sbjct: 379 QILMVLGAGRGPLVNASLRAAKQAERKIKVYAVEKNPNAVITLEGWRYEEWGSQVTVVSG 438 Query: 127 SVEDISLPEKVDVIISEWMGYFLLRESMFDSVISARDRWLKPTGVMYPSHARMWLAPIKS 186 + + PEK D+I+SE +G F E + + +LK GV P +LAPI S Sbjct: 439 DMREWKAPEKADIIVSELLGSFGDNE-LSPECLDGAQHFLKDDGVSIPGEYTSYLAPISS 497 Query: 187 N 187 + Sbjct: 498 S 498 >5FA5-A nrPDB Length = 650 Score = 42.7 bits (99), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 66/282 (23%), Positives = 107/282 (37%), Gaps = 54/282 (19%) Query: 72 KTVLDVGTGSGILAIWSAQAGAR-----KVYAVEATKMADHARALVKANNLDHIVEVIEG 126 + ++ +G G G L S +A + K+YAVE A + V V+ Sbjct: 372 QVLMVLGAGRGPLVNASLRAAKQADRRIKLYAVEKNPNAVVTLENWQFEEWGSQVTVVSS 431 Query: 127 SVEDISLPEKVDVIISEWMGYFLLRESMFDSVISARDRWLKPTGVMYPSHARMWLAPIKS 186 + + PEK D+I+SE +G F E + + +LK GV P +LAPI S Sbjct: 432 DMREWVAPEKADIIVSELLGSFADNE-LSPECLDGAQHFLKDDGVSIPGEYTSFLAPISS 490 Query: 187 NIADRKRNDFDGAMADWHNFSDEIKSYYGVDMGVLTKPFAEEQEKYYIQTAMWNDLNPQQ 246 + +E+++ D P A+ + Y ++ ++ L+ Q Sbjct: 491 S-----------------KLYNEVRACREKD----RDPEAQFEMPYVVRLHNFHQLSAPQ 529 Query: 247 IIGTPTIVKEMDCLTASVSEIEEVRSN---VTSVINME-HTRLCGFGGWFDVQFSGRKED 302 C T S + + N T +E +T L GF G+F+ Sbjct: 530 -----------PCFTFSHPNRDPMIDNNRYCTLEFPVEVNTVLHGFAGYFETVL------ 572 Query: 303 PAQQEIELTTAPSEQHCT---HWGQQVFIMSNPINVEEGDNL 341 Q+I L+ P E H W +F + PI V EG + Sbjct: 573 --YQDITLSIRP-ETHSPGMFSWFPILFPIKQPITVREGQTI 611 >3LPM-A nrPDB Length = 259 Score = 36.6 bits (83), Expect = 0.021, Method: Compositional matrix adjust. Identities = 26/90 (28%), Positives = 50/90 (55%), Gaps = 5/90 (5%) Query: 55 MDAYFNAVFQNKHHFEGKTVLDVGTGSGILAIWSAQAGARKVYAVEAT-KMADHARALVK 113 +DA A F +GK ++D+ +G+GI+ + + K+ VE ++AD A+ V Sbjct: 35 IDAVLLAKFSYLPIRKGK-IIDLCSGNGIIPLLLSTRTKAKIVGVEIQERLADMAKRSVA 93 Query: 114 ANNLDHIVEVIEGSVEDIS--LP-EKVDVI 140 N L+ +E+IE ++ I+ +P E+ D++ Sbjct: 94 YNQLEDQIEIIEYDLKKITDLIPKERADIV 123 >3DLC-A nrPDB Length = 219 Score = 35.4 bits (80), Expect = 0.041, Method: Compositional matrix adjust. Identities = 22/86 (25%), Positives = 46/86 (53%), Gaps = 2/86 (2%) Query: 65 NKHHFEGKTVLDVGTGSGILAIWSAQAGARKVYAVEATK-MADHARALVKANNLDHIVEV 123 N+ T +D+G+G G L+I A+ + A++ +K M + A + NL+ +++ Sbjct: 38 NRFGITAGTCIDIGSGPGALSIALAKQSDFSIRALDFSKHMNEIALKNIADANLNDRIQI 97 Query: 124 IEGSVEDISLPEK-VDVIISEWMGYF 148 ++G V +I + + D+I+S +F Sbjct: 98 VQGDVHNIPIEDNYADLIVSRGSVFF 123 >3AOX-A nrPDB Length = 344 Score = 35.0 bits (79), Expect = 0.060, Method: Compositional matrix adjust. Identities = 21/70 (30%), Positives = 39/70 (55%), Gaps = 6/70 (8%) Query: 261 TASVSEIEEV-RSNVTSVINMEHTRLCGFGGWFDVQFSGRKEDPAQQEIELTTAPSEQHC 319 T+S+S+++EV R N+T + + H FG ++ Q SG DP+ ++ + T P + C Sbjct: 35 TSSISDLKEVPRKNITLIRGLGHG---AFGEVYEGQVSGMPNDPSPLQVAVKTLP--EVC 89 Query: 320 THWGQQVFIM 329 + + F+M Sbjct: 90 SEQDELDFLM 99 >4PNE-A nrPDB Length = 302 Score = 33.9 bits (76), Expect = 0.11, Method: Compositional matrix adjust. Identities = 32/107 (29%), Positives = 49/107 (45%), Gaps = 11/107 (10%) Query: 71 GKTVLDVGTGSGILAIWSAQAGARKVYAVEATKM-----ADHARALVKANNLDHIVEVIE 125 G +LDVG G+G A+ A+ A ++ + +++ AD AR L H V+ Sbjct: 93 GVRLLDVGCGTGQPALRVARDNAIQITGITVSQVQVAIAADCARE----RGLSHRVDF-- 146 Query: 126 GSVEDISLPEKVDVIISEWMGYFLLRESMFDSVISARDRWLKPTGVM 172 V+ +SLP + + W LL S D I R LKP G++ Sbjct: 147 SCVDAMSLPYPDNAFDAAWAMQSLLEMSEPDRAIREILRVLKPGGIL 193 >4QNV-A nrPDB Length = 323 Score = 33.9 bits (76), Expect = 0.11, Method: Compositional matrix adjust. Identities = 27/115 (23%), Positives = 50/115 (43%), Gaps = 9/115 (7%) Query: 54 RMDAYFNAVFQNKHHFEGKTVLDVGTGSGILAIWSAQAGARKVYAVEATKM----ADHAR 109 R D ++ V + G+T+LDVG GSG AGA ++ T++ + R Sbjct: 106 RSDWKWDRVLPHLSDLTGRTILDVGCGSGYHMWRMIGAGAHLAVGIDPTQLFLCQFEAVR 165 Query: 110 ALVKANNLDHIVEVIEGSVEDISLPEKVDVIISEWMGYFLLRESMFDSVISARDR 164 L+ + H++ + +E + + D + S MG R S + + +D+ Sbjct: 166 KLLGNDQRAHLLPL---GIEQLPALKAFDTVFS--MGVLYHRRSPLEHLWQLKDQ 215 >1WY7-A nrPDB Length = 207 Score = 33.9 bits (76), Expect = 0.14, Method: Compositional matrix adjust. Identities = 16/36 (44%), Positives = 23/36 (63%) Query: 70 EGKTVLDVGTGSGILAIWSAQAGARKVYAVEATKMA 105 EGK V D+G G+G+L+ + GA++V VE K A Sbjct: 49 EGKVVADLGAGTGVLSYGALLLGAKEVICVEVDKEA 84 >3CJR-A nrPDB Length = 254 Score = 33.1 bits (74), Expect = 0.19, Method: Compositional matrix adjust. Identities = 25/65 (38%), Positives = 34/65 (52%), Gaps = 4/65 (6%) Query: 66 KHHFEGKTVLDVGTGSGILAIWSAQAGARKVYAVEATKMA-DHARALVKANNLDHIVEVI 124 +H G VLD+GTGSG+LAI + + G K V+ M A A K N + + Sbjct: 116 RHLRPGDKVLDLGTGSGVLAIAAEKLGG-KALGVDIDPMVLPQAEANAKRNGVRP--RFL 172 Query: 125 EGSVE 129 EGS+E Sbjct: 173 EGSLE 177 >4HTF-A nrPDB Length = 285 Score = 32.7 bits (73), Expect = 0.25, Method: Compositional matrix adjust. Identities = 27/103 (26%), Positives = 49/103 (47%), Gaps = 9/103 (8%) Query: 74 VLDVGTGSGILAIWSAQAGARKVYAVEATKMADHARALVKANNLDHIVEVIEGSVEDIS- 132 VLD G G G AI A+ G + + + +M D A+ +A + ++ I + +D++ Sbjct: 72 VLDAGGGEGQTAIKMAERGHQVILCDLSAQMIDRAKQAAEAKGVSDNMQFIHCAAQDVAS 131 Query: 133 -LPEKVDVIISEWMGYFLLRESMFDSVISARDRW--LKPTGVM 172 L VD+I+ + + E + D + W L+P GV+ Sbjct: 132 HLETPVDLIL-----FHAVLEWVADPRSVLQTLWSVLRPGGVL 169 >3P9N-A nrPDB Length = 189 Score = 32.7 bits (73), Expect = 0.26, Method: Compositional matrix adjust. Identities = 24/71 (33%), Positives = 36/71 (50%), Gaps = 6/71 (8%) Query: 50 SDRVRMDAYFNAVFQNKHHFEGKTVLDVGTGSGILAIWSAQAGARKVYAVEATKMADHAR 109 +DRVR ++ FN + + G VLD+ GSG L + + GA V VE +D Sbjct: 26 TDRVR-ESLFN-IVTARRDLTGLAVLDLYAGSGALGLEALSRGAASVLFVE----SDQRS 79 Query: 110 ALVKANNLDHI 120 A V A N++ + Sbjct: 80 AAVIARNIEAL 90 >3DUW-A nrPDB Length = 223 Score = 32.7 bits (73), Expect = 0.30, Method: Compositional matrix adjust. Identities = 22/63 (34%), Positives = 33/63 (52%), Gaps = 3/63 (4%) Query: 71 GKTVLDVGTGSGILAIWSAQ---AGARKVYAVEATKMADHARALVKANNLDHIVEVIEGS 127 + +L++GT G IW A+ +G R V + K AD AR+ ++ NL+ VEV G Sbjct: 59 ARNILEIGTLGGYSTIWLARGLSSGGRVVTLEASEKHADIARSNIERANLNDRVEVRTGL 118 Query: 128 VED 130 D Sbjct: 119 ALD 121 >5Z9O-A nrPDB Length = 399 Score = 32.3 bits (72), Expect = 0.39, Method: Compositional matrix adjust. Identities = 29/95 (30%), Positives = 44/95 (46%), Gaps = 5/95 (5%) Query: 38 TYSFLYHQKDMLSDRVRMD-AYFNAVFQNKHHFEGKTVLDVGTGSGILAIWSAQAGARKV 96 TYS Y D D + A + + H +GKT+LD+G G G L + +A+ KV Sbjct: 132 TYSCAYFTDDNKDDLEQAQIAKVHHILNKLHPEKGKTLLDIGCGWGTLMLTAAKEYGLKV 191 Query: 97 YAVEATKMADHARALVKANNLDHIVE-VIEGSVED 130 V +++ LV+ D +E V E +ED Sbjct: 192 TGV---TLSEEQYKLVQKKIYDEGLEDVAEVKLED 223 >4QPN-A nrPDB Length = 227 Score = 32.0 bits (71), Expect = 0.52, Method: Compositional matrix adjust. Identities = 24/108 (22%), Positives = 45/108 (41%), Gaps = 7/108 (6%) Query: 69 FEGKTVLDVGTGSGILAIWSAQAGARKVYAVEATKMADHARALVKAN---NLDHIVEVIE 125 F GK V+++G G+GI+ I +A G V + + + V+AN V + Sbjct: 75 FRGKKVIELGAGTGIVGILAALQGG-DVTITDLPLALEQIQGNVQANVPAGGQAQVRALS 133 Query: 126 GSVEDISLPEKVDVIISEWMGYFLLRESMFDSVISARDRWLKPTGVMY 173 ++ P D+++ + Y E F ++ +P G +Y Sbjct: 134 WGIDHHVFPANYDLVLGADIVYL---EPTFPLLLGTLQHLCRPHGTIY 178 >1QO0-D nrPDB Length = 196 Score = 31.6 bits (70), Expect = 0.54, Method: Compositional matrix adjust. Identities = 13/32 (40%), Positives = 18/32 (56%) Query: 53 VRMDAYFNAVFQNKHHFEGKTVLDVGTGSGIL 84 V +D F ++FQN+HH E +L GT L Sbjct: 51 VPVDVVFTSIFQNRHHDEIAALLAAGTPRTTL 82 >2ESR-A nrPDB Length = 177 Score = 31.2 bits (69), Expect = 0.77, Method: Compositional matrix adjust. Identities = 24/66 (36%), Positives = 34/66 (51%), Gaps = 7/66 (10%) Query: 50 SDRVRMDAYFNAVFQNKHHFEGKTVLDVGTGSGILAIWSAQAGARKVYAVEATKMADHAR 109 SD+VR A FN + +F G VLD+ GSG LAI + G VE + A+ Sbjct: 15 SDKVR-GAIFNMI---GPYFNGGRVLDLFAGSGGLAIEAVSRGMSAAVLVEKNR---KAQ 67 Query: 110 ALVKAN 115 A+++ N Sbjct: 68 AIIQDN 73 >3EGE-A nrPDB Length = 261 Score = 30.8 bits (68), Expect = 1.2, Method: Compositional matrix adjust. Identities = 27/84 (32%), Positives = 44/84 (52%), Gaps = 8/84 (9%) Query: 60 NAVFQNKHHFEGKTVLDVGTGSGILAIWSAQAGARKVYAVEATKMADHARALVKANNLDH 119 NA+ + +G + D+G G+G ++ A G VYAVE + + +A+V Sbjct: 24 NAIINLLNLPKGSVIADIGAGTGGYSVALANQGL-FVYAVEPS-IVMRQQAVVHPQ---- 77 Query: 120 IVEVIEGSVEDISLPEK-VDVIIS 142 VE G E+++LP+K VD +IS Sbjct: 78 -VEWFTGYAENLALPDKSVDGVIS 100 >1SDD-B nrPDB Length = 647 Score = 30.4 bits (67), Expect = 1.3, Method: Compositional matrix adjust. Identities = 13/36 (36%), Positives = 21/36 (58%) Query: 68 HFEGKTVLDVGTGSGILAIWSAQAGARKVYAVEATK 103 HF G+T+L+ GT L +W G+ K ++A+K Sbjct: 266 HFHGQTLLENGTQQHQLGVWPLLPGSFKTLEMKASK 301 >5WP5-A nrPDB Length = 491 Score = 30.4 bits (67), Expect = 1.4, Method: Compositional matrix adjust. Identities = 30/114 (26%), Positives = 56/114 (49%), Gaps = 19/114 (16%) Query: 69 FEGKTVLDVGTGSGILAIWSAQAGARKVYAVEATKMADHARALVKANNLDHIVEVIEGSV 128 +EGK+VL++G G G AQ A +V A++ + A+ K +++ + I+ Sbjct: 52 YEGKSVLELGAGIGRFTGELAQK-AGEVIALDFIE-----SAIQKNESVNGHYKNIKFMC 105 Query: 129 EDISLPE------KVDVIISEWMGYFLLR---ESMFDSVISARDRWLKPTGVMY 173 D++ P+ +D+I S W+ +L E M + +I W+KP G ++ Sbjct: 106 ADVTSPDLKIKDGSIDLIFSNWLLMYLSDKEVELMAERMIG----WVKPGGYIF 155 >4N17-A nrPDB Length = 335 Score = 30.0 bits (66), Expect = 1.8, Method: Compositional matrix adjust. Identities = 19/76 (25%), Positives = 35/76 (46%), Gaps = 8/76 (10%) Query: 59 FNAVFQNKHHFE-------GKTVLDVGTGSGILAIWSAQAGARKVYAVEATKMADHARAL 111 F +F++ HF G+ +LD G++A+ ++GAR +YA + + L Sbjct: 107 FPFLFRDVDHFRKAMYGPAGQKILDAFAAKGMIALTFYESGARSIYAKRPVRTPADMKGL 166 Query: 112 -VKANNLDHIVEVIEG 126 V+ D +V+ I Sbjct: 167 KVRVQPSDLMVDEIRA 182 >4KDR-A nrPDB Length = 223 Score = 30.0 bits (66), Expect = 1.8, Method: Compositional matrix adjust. Identities = 21/63 (33%), Positives = 30/63 (47%), Gaps = 14/63 (22%) Query: 71 GKTVLDVGTGSGILAIWSAQAGAR--------------KVYAVEATKMADHARALVKANN 116 GK VLDVG G GILA A+ GA K++A+E+ D+ + V+ + Sbjct: 63 GKKVLDVGCGGGILAESMAREGATVTGLDMGFEPLQVAKLHALESGIQVDYVQETVEEHA 122 Query: 117 LDH 119 H Sbjct: 123 AKH 125 >4KDC-A nrPDB Length = 246 Score = 29.6 bits (65), Expect = 2.1, Method: Compositional matrix adjust. Identities = 21/63 (33%), Positives = 30/63 (47%), Gaps = 14/63 (22%) Query: 71 GKTVLDVGTGSGILAIWSAQAGAR--------------KVYAVEATKMADHARALVKANN 116 GK VLDVG G GILA A+ GA K++A+E+ D+ + V+ + Sbjct: 63 GKKVLDVGCGGGILAESMAREGATVTGLDMGFEPLQVAKLHALESGIQVDYVQETVEEHA 122 Query: 117 LDH 119 H Sbjct: 123 AKH 125 >1KR5-A nrPDB Length = 226 Score = 29.6 bits (65), Expect = 2.4, Method: Compositional matrix adjust. Identities = 24/78 (30%), Positives = 36/78 (46%), Gaps = 19/78 (24%) Query: 55 MDAYFNAVFQNKHHFEGKTVLDVGTGSGIL-AIWSAQAGARKVYAVEATKMADHARALVK 113 M AY + ++ H EG LDVG+GSGIL A ++ G K Sbjct: 63 MHAYALELLFDQLH-EGAKALDVGSGSGILTACFARMVGCTG-----------------K 104 Query: 114 ANNLDHIVEVIEGSVEDI 131 +DHI E+++ SV ++ Sbjct: 105 VIGIDHIKELVDDSVNNV 122 >4OIW-A nrPDB Length = 431 Score = 29.3 bits (64), Expect = 2.7, Method: Compositional matrix adjust. Identities = 19/59 (32%), Positives = 28/59 (47%) Query: 76 DVGTGSGILAIWSAQAGARKVYAVEATKMADHARALVKANNLDHIVEVIEGSVEDISLP 134 D+G GS I I ++Q G R V T R L +++L H+V+V+ LP Sbjct: 373 DMGCGSTIGPITASQVGVRTVDIGLPTFAMHSIRELAGSHDLAHLVKVLGAFYASSELP 431 >4KRG-A nrPDB Length = 466 Score = 29.3 bits (64), Expect = 2.7, Method: Compositional matrix adjust. Identities = 29/142 (20%), Positives = 58/142 (40%), Gaps = 38/142 (26%) Query: 68 HFEGKTVLDVGTGSGILAIWSAQAGARKVYAVEATKMADHARALVKANNLDHIVEVIE-- 125 H K V+D+G G G T +A+ AR ++ + ++ +E + Sbjct: 55 HLTNKDVVDIGAGIGRF----------------TTVLAETARWVLSTDFIESFIEKNQER 98 Query: 126 -----------GSVEDISLPEK-VDVIISEWMGYFLLRESMFDSVISARDRWLKPTGVMY 173 G + + EK VD++ + W+ +L + + +++A RWL+ G ++ Sbjct: 99 NAHMGNISYQIGDAVHLQMDEKSVDLVFTNWLMMYLSDREVIEFLLNAM-RWLRADGYIH 157 Query: 174 -------PSHARMWLAPIKSNI 188 PS R+ A + S + Sbjct: 158 LRESCSEPSTGRLKTATMHSAV 179 >5EUY-A nrPDB Length = 491 Score = 29.3 bits (64), Expect = 2.9, Method: Compositional matrix adjust. Identities = 18/61 (29%), Positives = 28/61 (45%), Gaps = 9/61 (14%) Query: 4 SQNGGAMGGRAAGT--------GGGGPSAPVDK-EVDYAQYFCTYSFLYHQKDMLSDRVR 54 S G + +AAGT GG P +D +VDYA ++ L+HQ + + R Sbjct: 233 SSTGREIAAKAAGTLKTVTLELGGSDPLIILDDVDVDYAARLAVFASLFHQGQICTSAKR 292 Query: 55 M 55 + Sbjct: 293 I 293 >2AS0-A nrPDB Length = 396 Score = 29.3 bits (64), Expect = 3.4, Method: Compositional matrix adjust. Identities = 21/58 (36%), Positives = 33/58 (56%), Gaps = 1/58 (1%) Query: 71 GKTVLDVGTGSGILAIWSAQAGARKVYAVEATKMA-DHARALVKANNLDHIVEVIEGS 127 G VLDV T +G AI +A AGA +V ++ + A + A+ K N ++ ++ I GS Sbjct: 218 GDRVLDVFTYTGGFAIHAAIAGADEVIGIDKSPRAIETAKENAKLNGVEDRMKFIVGS 275 >2VS1-A nrPDB Length = 425 Score = 28.9 bits (63), Expect = 3.7, Method: Compositional matrix adjust. Identities = 21/65 (32%), Positives = 34/65 (52%), Gaps = 2/65 (3%) Query: 60 NAVFQNKHHFEGKTVLDVGTGSGILAIWSAQAGARKVYAVEATKMA-DHARALVKANNLD 118 N V + EG+ +LD+ +G G I+ A+ G V ++ + A + AR V+ NN+D Sbjct: 280 NLVRKVSELVEGEKILDMYSGVGTFGIYLAKRGF-NVKGFDSNEFAIEMARRNVEINNVD 338 Query: 119 HIVEV 123 EV Sbjct: 339 AEFEV 343 >3OPN-A nrPDB Length = 232 Score = 28.9 bits (63), Expect = 4.3, Method: Compositional matrix adjust. Identities = 15/36 (41%), Positives = 21/36 (58%), Gaps = 2/36 (5%) Query: 68 HFE--GKTVLDVGTGSGILAIWSAQAGARKVYAVEA 101 H E GKT LD+G+ +G Q GA+ VYA++ Sbjct: 33 HLEINGKTCLDIGSSTGGFTDVMLQNGAKLVYALDV 68 >6F5Z-A nrPDB Length = 231 Score = 28.5 bits (62), Expect = 5.3, Method: Compositional matrix adjust. Identities = 18/54 (33%), Positives = 29/54 (53%), Gaps = 2/54 (3%) Query: 70 EGKTVLDVGTGSG--ILAIWSAQAGARKVYAVEATKMADHARALVKANNLDHIV 121 EG TV+D+GTGSG + A+ + R + +M +ARA ++L +V Sbjct: 38 EGDTVVDLGTGSGYALRALRDTKGIGRGFGLDGSPEMVQNARAYTDTDDLSFLV 91 >4O29-A nrPDB Length = 208 Score = 28.5 bits (62), Expect = 5.8, Method: Compositional matrix adjust. Identities = 23/63 (36%), Positives = 32/63 (50%), Gaps = 11/63 (17%) Query: 71 GKTVLDVGTGSGILAIWSAQAGARK--VYAVEATKMADHARALVKANNLDH-----IVEV 123 G +L+VGTGSG A A+A +K +Y +E K A+ A NL+ +VEV Sbjct: 76 GMKILEVGTGSGYHAAVCAEAIEKKGRIYTIEIVK----ELAVFAAQNLERLGYWGVVEV 131 Query: 124 IEG 126 G Sbjct: 132 YHG 134 >3CCF-A nrPDB Length = 279 Score = 28.1 bits (61), Expect = 6.7, Method: Compositional matrix adjust. Identities = 19/63 (30%), Positives = 29/63 (46%), Gaps = 15/63 (23%) Query: 62 VFQNKHHF---------------EGKTVLDVGTGSGILAIWSAQAGARKVYAVEATKMAD 106 ++Q+KH F G+ +LD+G G+G L AQ+GA + A M + Sbjct: 34 LYQDKHSFVWQYGEDLLQLLNPQPGEFILDLGCGTGQLTEKIAQSGAEVLGTDNAATMIE 93 Query: 107 HAR 109 AR Sbjct: 94 KAR 96 >1VQ1-A nrPDB Length = 294 Score = 27.7 bits (60), Expect = 7.8, Method: Compositional matrix adjust. Identities = 13/34 (38%), Positives = 20/34 (58%) Query: 72 KTVLDVGTGSGILAIWSAQAGARKVYAVEATKMA 105 KTV D+GTGSG + + A+ V+A + + A Sbjct: 135 KTVADIGTGSGAIGVSVAKFSDAIVFATDVSSKA 168 >6BQC-A nrPDB Length = 383 Score = 27.7 bits (60), Expect = 8.8, Method: Compositional matrix adjust. Identities = 50/198 (25%), Positives = 72/198 (36%), Gaps = 41/198 (20%) Query: 32 YAQYFCTYSFLYHQKDMLSDRVRMDAYFNAVFQNKHHFEGKTVLDVGTGSGILAIWSAQA 91 + QY C Y KD + A + + G VLD+G G G LA + A Sbjct: 135 FMQYSCAY-----WKDADNLESAQQAKLKMICEKLQLKPGMRVLDIGCGWGGLAHYMASN 189 Query: 92 GARKVYAV----EATKMADHARALVKANNLDHIVEVIEGSVEDISLPEKVDVIISEWMGY 147 V V E KMA + LD V ++ D++ ++ D I+S +G Sbjct: 190 YDVSVVGVTISAEQQKMAQE-----RCEGLD--VTILLQDYRDLN--DQFDRIVS--VGM 238 Query: 148 F-LLRESMFDSVISARDRWLKPTGVMYPS---------HARMWL---------APIKSNI 188 F + +D+ + DR LKP G+ + W+ P I Sbjct: 239 FEHVGPKNYDTYFAVVDRNLKPEGIFLLHTIGSKKTDLNVDPWINKYIFPNGCLPSVRQI 298 Query: 189 ADRKRNDFDGAMADWHNF 206 A F M DWHNF Sbjct: 299 AQSSEPHF--VMEDWHNF 314 >3GRV-A nrPDB Length = 295 Score = 27.7 bits (60), Expect = 9.1, Method: Compositional matrix adjust. Identities = 20/65 (30%), Positives = 32/65 (49%), Gaps = 2/65 (3%) Query: 40 SFLYHQKDMLSDRVRMDAYF-NAVFQNKHHFEGKTVLDVGTGSGILAIWSAQAGARKVYA 98 S ++ K L +D F N ++ + + VL++G G GIL A+ A+KVY Sbjct: 19 SHMFKPKKKLGQCFLIDKNFVNKAVESANLTKDDVVLEIGLGKGILTEELAK-NAKKVYV 77 Query: 99 VEATK 103 +E K Sbjct: 78 IEIDK 82 >3FYD-A nrPDB Length = 263 Score = 27.7 bits (60), Expect = 9.2, Method: Compositional matrix adjust. Identities = 14/31 (45%), Positives = 19/31 (61%), Gaps = 1/31 (3%) Query: 73 TVLDVGTGSGILAIWSAQAGARKVYAVEATK 103 VL++G G GIL A+ A+KVY +E K Sbjct: 24 VVLEIGLGKGILTEELAK-NAKKVYVIEIDK 53 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 3R0Q-C nrPDB 517 e-147 5JMQ-A nrPDB 414 e-116 3Q7E-A nrPDB 384 e-107 5EGS-A nrPDB 384 e-107 5LV5-A nrPDB 384 e-107 5DST-A nrPDB 380 e-106 5FUB-A nrPDB 369 e-102 4RYL-A nrPDB 368 e-102 1F3L-A nrPDB 364 e-101 6CU3-A nrPDB 353 5e-98 1G6Q-1 nrPDB 352 2e-97 5IS8-A nrPDB 320 8e-88 3B3J-A nrPDB 320 8e-88 4IKP-A nrPDB 320 8e-88 4LWO-B nrPDB 269 2e-72 5FA5-A nrPDB 223 6e-59 4G56-A nrPDB 214 6e-56 6OGN-A nrPDB 203 1e-52 3X0D-A nrPDB 176 1e-44 5EKU-A nrPDB 170 7e-43 4M36-A nrPDB 170 8e-43 Sequences not found previously or not previously below threshold: 3UA4-A nrPDB 113 2e-25 1WY7-A nrPDB 51 6e-07 1L3B-A nrPDB 50 2e-06 2AS0-A nrPDB 49 4e-06 3DLC-A nrPDB 48 8e-06 3SVZ-A nrPDB 48 9e-06 5Z9O-A nrPDB 47 2e-05 3LPM-A nrPDB 45 5e-05 5JE5-A nrPDB 45 6e-05 2ZZN-A nrPDB 44 8e-05 3D2L-A nrPDB 44 9e-05 4KDR-A nrPDB 43 2e-04 4KDC-A nrPDB 43 2e-04 4KRG-A nrPDB 43 3e-04 1XDU-A nrPDB 43 3e-04 4LG1-A nrPDB 42 4e-04 5WP5-A nrPDB 42 4e-04 3A26-A nrPDB 42 5e-04 5FAD-A nrPDB 41 6e-04 6GKZ-A nrPDB 41 7e-04 4PNE-A nrPDB 41 0.001 5YAC-A nrPDB 40 0.002 3EGE-A nrPDB 40 0.002 3CJR-A nrPDB 40 0.002 2PJD-A nrPDB 39 0.002 4QNV-A nrPDB 39 0.002 4QPN-A nrPDB 39 0.003 4FS8-A nrPDB 39 0.003 1DUS-A nrPDB 39 0.004 5BP9-A nrPDB 38 0.006 2YXD-A nrPDB 38 0.007 4P7C-A nrPDB 38 0.008 5I2H-A nrPDB 38 0.009 3DMF-A nrPDB 38 0.010 2XVM-A nrPDB 38 0.011 1VQ1-A nrPDB 37 0.013 3GRV-A nrPDB 37 0.017 3FYD-A nrPDB 37 0.017 3CCF-A nrPDB 37 0.018 1I9G-A nrPDB 37 0.018 5WP4-A nrPDB 37 0.018 1RI1-A nrPDB 36 0.020 4O29-A nrPDB 36 0.026 3M70-A nrPDB 36 0.037 6M83-A nrPDB 36 0.039 2AVN-A nrPDB 35 0.053 5U19-A nrPDB 35 0.057 5GM1-A nrPDB 35 0.068 2I6G-A nrPDB 34 0.082 5W7M-A nrPDB 34 0.083 4HTF-A nrPDB 34 0.088 5H02-A nrPDB 34 0.091 1ZQ9-A nrPDB 34 0.13 5BXY-A nrPDB 34 0.13 2B25-A nrPDB 34 0.13 6DCC-A nrPDB 33 0.16 1KP9-A nrPDB 33 0.19 6C5B-A nrPDB 33 0.22 3NJR-A nrPDB 33 0.24 2YVL-A nrPDB 33 0.24 5EHG-A nrPDB 33 0.26 4V0R-A nrPDB 33 0.26 6BQC-A nrPDB 33 0.28 4DCM-A nrPDB 33 0.32 3DOO-A nrPDB 33 0.32 5IKM-A nrPDB 33 0.33 3BKX-A nrPDB 33 0.33 2VS1-A nrPDB 32 0.37 3C3P-A nrPDB 32 0.43 3OPN-A nrPDB 32 0.44 3HP7-A nrPDB 32 0.58 5MGZ-A nrPDB 32 0.59 3QPM-A nrPDB 31 0.62 3P9N-A nrPDB 31 0.72 4QDJ-A nrPDB 31 0.77 1R74-A nrPDB 31 0.85 6H1E-A nrPDB 31 0.96 2OXT-A nrPDB 31 1.0 4LEC-A nrPDB 31 1.2 4MTL-A nrPDB 31 1.3 1D2C-A nrPDB 30 1.7 3R9X-B nrPDB 29 2.5 6ERQ-F nrPDB 29 2.9 6ERO-A nrPDB 29 2.9 1GKM-A nrPDB 28 5.2 >3R0Q-C nrPDB Length = 376 Score = 517 bits (1330), Expect = e-147, Method: Composition-based stats. Identities = 373/373 (100%), Positives = 373/373 (100%) Query: 11 GGRAAGTGGGGPSAPVDKEVDYAQYFCTYSFLYHQKDMLSDRVRMDAYFNAVFQNKHHFE 70 GGRAAGTGGGGPSAPVDKEVDYAQYFCTYSFLYHQKDMLSDRVRMDAYFNAVFQNKHHFE Sbjct: 4 GGRAAGTGGGGPSAPVDKEVDYAQYFCTYSFLYHQKDMLSDRVRMDAYFNAVFQNKHHFE 63 Query: 71 GKTVLDVGTGSGILAIWSAQAGARKVYAVEATKMADHARALVKANNLDHIVEVIEGSVED 130 GKTVLDVGTGSGILAIWSAQAGARKVYAVEATKMADHARALVKANNLDHIVEVIEGSVED Sbjct: 64 GKTVLDVGTGSGILAIWSAQAGARKVYAVEATKMADHARALVKANNLDHIVEVIEGSVED 123 Query: 131 ISLPEKVDVIISEWMGYFLLRESMFDSVISARDRWLKPTGVMYPSHARMWLAPIKSNIAD 190 ISLPEKVDVIISEWMGYFLLRESMFDSVISARDRWLKPTGVMYPSHARMWLAPIKSNIAD Sbjct: 124 ISLPEKVDVIISEWMGYFLLRESMFDSVISARDRWLKPTGVMYPSHARMWLAPIKSNIAD 183 Query: 191 RKRNDFDGAMADWHNFSDEIKSYYGVDMGVLTKPFAEEQEKYYIQTAMWNDLNPQQIIGT 250 RKRNDFDGAMADWHNFSDEIKSYYGVDMGVLTKPFAEEQEKYYIQTAMWNDLNPQQIIGT Sbjct: 184 RKRNDFDGAMADWHNFSDEIKSYYGVDMGVLTKPFAEEQEKYYIQTAMWNDLNPQQIIGT 243 Query: 251 PTIVKEMDCLTASVSEIEEVRSNVTSVINMEHTRLCGFGGWFDVQFSGRKEDPAQQEIEL 310 PTIVKEMDCLTASVSEIEEVRSNVTSVINMEHTRLCGFGGWFDVQFSGRKEDPAQQEIEL Sbjct: 244 PTIVKEMDCLTASVSEIEEVRSNVTSVINMEHTRLCGFGGWFDVQFSGRKEDPAQQEIEL 303 Query: 311 TTAPSEQHCTHWGQQVFIMSNPINVEEGDNLNLGLLMSRSKENHRLMEIELNCEIKEASG 370 TTAPSEQHCTHWGQQVFIMSNPINVEEGDNLNLGLLMSRSKENHRLMEIELNCEIKEASG Sbjct: 304 TTAPSEQHCTHWGQQVFIMSNPINVEEGDNLNLGLLMSRSKENHRLMEIELNCEIKEASG 363 Query: 371 NPKESFKKTYFIE 383 NPKESFKKTYFIE Sbjct: 364 NPKESFKKTYFIE 376 >5JMQ-A nrPDB Length = 446 Score = 414 bits (1064), Expect = e-116, Method: Composition-based stats. Identities = 117/380 (30%), Positives = 186/380 (48%), Gaps = 30/380 (7%) Query: 12 GRAAGTGGGGPSAPVDKEVDY---------AQYFCTYSFLYHQKDMLSDRVRMDAYFNAV 62 G AG G P+ + K+++ +YF +Y L +ML+D+ R Y + + Sbjct: 83 GERAGCCGYIPANHLGKQLEEYDPEDTWQDEEYFDSYGTLKLHLEMLADQPRTTKYHSVI 142 Query: 63 FQNKHHFEGKTVLDVGTGSGILAIWSAQ-AGARKVYAVEATKMADHARALVKANNLDHIV 121 QNK + K +LDVG G+GI++++ A A + VYAVEA+ MA H LV N + Sbjct: 143 LQNKESLKDKVILDVGCGTGIISLFCAHHARPKAVYAVEASDMAQHTSQLVLQNGFADTI 202 Query: 122 EVIEGSVEDISLPEKVDVIISEWMGYFLLRESMFDSVISARDRWLKPTGVMYPSHARMWL 181 V + VED+ LPEKVDV++SEWMG LL E M +S++ ARD WLK G+++P+ A + L Sbjct: 203 TVFQQKVEDVVLPEKVDVLVSEWMGTCLLFEFMIESILYARDTWLKGDGIIWPTTAALHL 262 Query: 182 APIKSNIADRKRNDFDGAMADWHNFSDEIKSYYGVDMGVLTKPFAEEQEKYYIQTAMWND 241 P + D+ + W N Y ++ L +E ++ + + Sbjct: 263 VPCSAE------KDYHSKVLFWDN-------AYEFNLSALKSLAIKE---FFSRPKSNHI 306 Query: 242 LNPQQIIGTPTIVKEMDCLTASVSEIEEVRSNVTSVINMEHTRLCGFGGWFDVQFSGRKE 301 L P+ + P + ++D T V ++E +R + I T L GF WF V F +E Sbjct: 307 LKPEDCLSEPCTILQLDMRTVQVPDLETMRGELRFDIQKAGT-LHGFTAWFSVYFQSLEE 365 Query: 302 DPAQQEIELTTAPSEQHCTHWGQQVFIMSNPINVEEGDNLNLGLLMSRSKENHRLMEIEL 361 QQ L+T P THW Q +F+M +P+ V GD + +++ R+ R M + L Sbjct: 366 GQPQQ--VLSTGPLHP-TTHWKQTLFMMDDPVPVHTGDVVTGSVVLQRNPVWRRHMSVSL 422 Query: 362 NCEIKEASGNPKESFKKTYF 381 + + A + + F Sbjct: 423 SWVVTSALDPTSQRVGEKVF 442 >3Q7E-A nrPDB Length = 349 Score = 384 bits (987), Expect = e-107, Method: Composition-based stats. Identities = 112/356 (31%), Positives = 195/356 (54%), Gaps = 33/356 (9%) Query: 17 TGGGGPSAPVDKEVDYA---QYFCTYSFLYHQKDMLSDRVRMDAYFNAVFQNKHHFEGKT 73 + G S+ D YF +Y+ +++L D VR Y N++F N+H F+ K Sbjct: 10 SCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHEELLKDEVRTLTYRNSMFHNRHLFKDKV 69 Query: 74 VLDVGTGSGILAIWSAQAGARKVYAVEATKMADHARALVKANNLDHIVEVIEGSVEDISL 133 VLDVG+G+GIL +++A+AGARKV +E + ++D+A +VKAN LDH+V +I+G VE++ L Sbjct: 70 VLDVGSGTGILCMFAAKAGARKVIGIECSSISDYAVKIVKANKLDHVVTIIKGKVEEVEL 129 Query: 134 P-EKVDVIISEWMGYFLLRESMFDSVISARDRWLKPTGVMYPSHARMWLAPIKSNIADRK 192 P EKVD+IISEWMGY L ESM ++V+ ARD+WL P G+++P A +++ I+ DR+ Sbjct: 130 PVEKVDIIISEWMGYCLFYESMLNTVLHARDKWLAPDGLIFPDRATLYVTAIE----DRQ 185 Query: 193 RNDFDGAMADWHNFSDEIKSYYGVDMGVLTKPFAEEQEKYYIQTAMWNDLNPQQIIGTPT 252 D+ + W N YG DM + +E + + ++P+Q++ Sbjct: 186 YKDY--KIHWWENV-------YGFDMSCIKDVAIKE--------PLVDVVDPKQLVTNAC 228 Query: 253 IVKEMDCLTASVSEIEEVRSNVTSVINMEHTRLCGFGGWFDVQFSGRKEDPAQQEIELTT 312 ++KE+D T V ++ V ++ + +F+++F+ + +T Sbjct: 229 LIKEVDIYTVKVEDLTFTSPFCLQVKRNDY--VHALVAYFNIEFTR-----CHKRTGFST 281 Query: 313 APSEQHCTHWGQQVFIMSNPINVEEGDNLNLGLLMSRSKENHRLMEIELNCEIKEA 368 +P + THW Q VF M + + V+ G+ + + M + +N+R ++ ++ + K Sbjct: 282 SPESPY-THWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQ 336 >5EGS-A nrPDB Length = 376 Score = 384 bits (986), Expect = e-107, Method: Composition-based stats. Identities = 115/350 (32%), Positives = 191/350 (54%), Gaps = 23/350 (6%) Query: 28 KEVDYAQYFCTYSFLYHQKDMLSDRVRMDAYFNAVFQNKHHFEGKTVLDVGTGSGILAIW 87 +E D Y+ YS + ++M++DRVR DAY + +N GKTVLDVG G+GIL+I+ Sbjct: 42 RERDQL-YYECYSDVSVHEEMIADRVRTDAYRLGILRNWAALRGKTVLDVGAGTGILSIF 100 Query: 88 SAQAGARKVYAVEATKMADHARALVKANNLDHIVEVIEGSVEDISLPEKVDVIISEWMGY 147 AQAGAR+VYAVEA+ + AR +V+ N L+ V V+ G VE + LPE+VD I+SEWMGY Sbjct: 101 CAQAGARRVYAVEASAIWQQAREVVRFNGLEDRVHVLPGPVETVELPEQVDAIVSEWMGY 160 Query: 148 FLLRESMFDSVISARDRWLKPTGVMYPSHARMWLAPIKSNIADRKRNDFDGAMADWHNFS 207 LL ESM SV+ AR +WLK G++ P+ A +++ PI + + F Sbjct: 161 GLLHESMLSSVLHARTKWLKEGGLLLPASAELFIVPISDQMLE-----------WRLGFW 209 Query: 208 DEIKSYYGVDMGVLTKPFAEEQEKYYIQTAMWNDLNPQQIIGTPTIVKEMDCLTASVSEI 267 ++K +YGVDM L + FA + + + L+ + ++ P +++ A + Sbjct: 210 SQVKQHYGVDMSCL-EGFATRCLMGHSEI-VVQGLSGEDVLARPQRFAQLELSRAGLE-- 265 Query: 268 EEVRSNVTSVINME---HTRLCGFGGWFDVQFSGRKEDPAQQEIELTTAPSEQHCTHWGQ 324 +E+ + V + GF WF V F G + +++ + L+T+P THW Q Sbjct: 266 QELEAGVGGRFRCSCYGSAPMHGFAIWFQVTFPGGE---SEKPLVLSTSPFHP-ATHWKQ 321 Query: 325 QVFIMSNPINVEEGDNLNLGLLMSRSKENHRLMEIELNCEIKEASGNPKE 374 + ++ P+ VE+ +++ + + S++N R + + L ++ + K+ Sbjct: 322 ALLYLNEPVQVEQDTDVSGEITLLPSRDNPRRLRVLLRYKVGDQEEKTKD 371 >5LV5-A nrPDB Length = 403 Score = 384 bits (986), Expect = e-107, Method: Composition-based stats. Identities = 116/349 (33%), Positives = 190/349 (54%), Gaps = 23/349 (6%) Query: 29 EVDYAQYFCTYSFLYHQKDMLSDRVRMDAYFNAVFQNKHHFEGKTVLDVGTGSGILAIWS 88 E D Y+ YS + ++M++D+VR +AY + +N GKTVLDVG G+GIL+I+ Sbjct: 70 ERDQL-YYECYSDVSVHEEMIADQVRTEAYRLGILKNWAALRGKTVLDVGAGTGILSIFC 128 Query: 89 AQAGARKVYAVEATKMADHARALVKANNLDHIVEVIEGSVEDISLPEKVDVIISEWMGYF 148 AQAGAR+VYAVEA+ + AR +V+ N L+ V V+ G VE + LPE+VD I+SEWMGY Sbjct: 129 AQAGARRVYAVEASAIWQQAREVVRLNGLEDRVHVLPGPVETVELPERVDAIVSEWMGYG 188 Query: 149 LLRESMFDSVISARDRWLKPTGVMYPSHARMWLAPIKSNIADRKRNDFDGAMADWHNFSD 208 LL ESM SV+ AR +WLK G++ P+ A +++API + + F Sbjct: 189 LLHESMLSSVLHARTKWLKEGGLLLPASAELFVAPISDQMLE-----------WRLGFWS 237 Query: 209 EIKSYYGVDMGVLTKPFAEEQEKYYIQTAMWNDLNPQQIIGTPTIVKEMDCLTASVSEIE 268 ++K +YGVDM + + FA + + + DL+ + ++ P +++ A + + Sbjct: 238 QVKQHYGVDMSCM-ESFATRCLMGHSEI-VVQDLSGEDVLARPQRFAQLELARAGLE--Q 293 Query: 269 EVRSNVTSVINME---HTRLCGFGGWFDVQFSGRKEDPAQQEIELTTAPSEQHCTHWGQQ 325 E+ + V L GF WF V F G +++ + L+T+P THW Q Sbjct: 294 ELEAGVGGRFRCSCYGSAPLHGFAVWFQVTFPG---GDSEKPLVLSTSPLHP-ATHWKQA 349 Query: 326 VFIMSNPINVEEGDNLNLGLLMSRSKENHRLMEIELNCEIKEASGNPKE 374 + ++ P+ VE+ +++ + + S +N R + I L ++ + K+ Sbjct: 350 LLYLNEPVPVEQDTDISGEITLLPSPDNPRRLRILLRYKVGDHEEKTKD 398 >5DST-A nrPDB Length = 332 Score = 380 bits (975), Expect = e-106, Method: Composition-based stats. Identities = 108/343 (31%), Positives = 195/343 (56%), Gaps = 30/343 (8%) Query: 27 DKEVDYAQYFCTYSFLYHQKDMLSDRVRMDAYFNAVFQNKHHFEGKTVLDVGTGSGILAI 86 ++ YF +Y+ ++ML D VR Y N+++ NKH F+ K VLDVG+G+GIL++ Sbjct: 6 EEMTSRDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMYHNKHVFKDKVVLDVGSGTGILSM 65 Query: 87 WSAQAGARKVYAVEATKMADHARALVKANNLDHIVEVIEGSVEDISLP-EKVDVIISEWM 145 ++A+AGA+KV+ +E + ++D++ ++KAN+LD+I+ + +G VE++ LP EKVD+IISEWM Sbjct: 66 FAAKAGAKKVFGIECSSISDYSEKIIKANHLDNIITIFKGKVEEVELPVEKVDIIISEWM 125 Query: 146 GYFLLRESMFDSVISARDRWLKPTGVMYPSHARMWLAPIKSNIADRKRNDFDGAMADWHN 205 GY L ESM ++VI ARD+WLKP G+M+P A +++ I+ DR+ DF + W N Sbjct: 126 GYCLFYESMLNTVIFARDKWLKPGGLMFPDRAALYVVAIE----DRQYKDF--KIHWWEN 179 Query: 206 FSDEIKSYYGVDMGVLTKPFAEEQEKYYIQTAMWNDLNPQQIIGTPTIVKEMDCLTASVS 265 YG DM + +E + + ++P+Q++ ++KE+D T Sbjct: 180 V-------YGFDMTCIRDVAMKE--------PLVDIVDPKQVVTNACLIKEVDIYTVKTE 224 Query: 266 EIEEVRSNVTSVINMEHTRLCGFGGWFDVQFSGRKEDPAQQEIELTTAPSEQHCTHWGQQ 325 E+ + + ++ + +F+++F+ +++ +TAP + THW Q Sbjct: 225 ELSFTSAFCLQIQRNDY--VHALVTYFNIEFT-----KCHKKMGFSTAPDAPY-THWKQT 276 Query: 326 VFIMSNPINVEEGDNLNLGLLMSRSKENHRLMEIELNCEIKEA 368 VF + + + V G+ + + M + +N R ++ ++ + K Sbjct: 277 VFYLEDYLTVRRGEEIYGTISMKPNAKNVRDLDFTVDLDFKGQ 319 >5FUB-A nrPDB Length = 337 Score = 369 bits (947), Expect = e-102, Method: Composition-based stats. Identities = 113/340 (33%), Positives = 173/340 (50%), Gaps = 21/340 (6%) Query: 34 QYFCTYSFLYHQKDMLSDRVRMDAYFNAVFQNKHHFEGKTVLDVGTGSGILAIWSAQ-AG 92 +YF Y L +MLSD+ R + Y + N K VLD+G G+G+++++ A A Sbjct: 8 EYFGNYGTLRLHLEMLSDKPRTETYRQVILSNSAALREKVVLDLGCGTGVISLFCALLAK 67 Query: 93 ARKVYAVEATKMADHARALVKANNLDHIVEVIEGSVEDISLPEKVDVIISEWMGYFLLRE 152 VYAVEA+ MA+H LVK N D +V V + E+++LP KVDV++SEWMG LL E Sbjct: 68 PAGVYAVEASSMAEHTEELVKQNGCDGVVTVFQERAENLTLPTKVDVLVSEWMGNCLLFE 127 Query: 153 SMFDSVISARDRWLKPTGVMYPSHARMWLAPIKSNIADRKRNDFDGAMADWHNFSDEIKS 212 M +SV+ ARDRWLK G+M+PS A + + P ++ R++ +F W N Sbjct: 128 YMLESVLLARDRWLKKGGMMWPSSACLTIVPCQAFSDYRQKVEF------WEN------- 174 Query: 213 YYGVDMGVLTKPFAEEQEKYYIQTAMWNDLNPQQIIGTPTIVKEMDCLTASVSEIEEVRS 272 YG++ L +E + + + L P+ + TP V +D +T VS++E ++ Sbjct: 175 PYGLNFSYLQSLAQKE---FLSKPKFSHHLQPEDCLSTPADVITLDMVTIQVSDLERLKG 231 Query: 273 NVTSVINMEHTRLCGFGGWFDVQFSGRKEDPAQQEIELTTAPSEQHCTHWGQQVFIMSNP 332 T + GF WF F +ED IEL T P + THW Q +F++ P Sbjct: 232 EFTFTVEKSG-MFHGFTVWFSAHFQCLEEDGPS--IELNTGPYSE-ITHWKQTLFMLDAP 287 Query: 333 INVEEGDNLNLGLLMSRSKENHRLMEIELNCEIKEASGNP 372 ++VEEGD + + + R+ R + I I + Sbjct: 288 VSVEEGDIIAGSIRLQRNPIWRRHLSITFLWNINSTEVST 327 >4RYL-A nrPDB Length = 340 Score = 368 bits (943), Expect = e-102, Method: Composition-based stats. Identities = 113/347 (32%), Positives = 186/347 (53%), Gaps = 31/347 (8%) Query: 19 GGGPSAPVDKEVDYAQYFCTYSFLYHQKDMLSDRVRMDAYFNAVFQNKHHFEGKTVLDVG 78 G P +E + YF +Y ++ML D++R ++Y + ++QN H F+ K VLDVG Sbjct: 13 GLVPRGSDLQEDEDGVYFSSYGHYGIHEEMLKDKIRTESYRDFIYQNPHIFKDKVVLDVG 72 Query: 79 TGSGILAIWSAQAGARKVYAVEATKMADHARALVKANNLDHIVEVIEGSVEDISLP-EKV 137 G+GIL++++A+AGA+KV V+ +++ A +++ N L+ + +I+G +E++ LP EKV Sbjct: 73 CGTGILSMFAAKAGAKKVLGVDQSEILYQAMDIIRLNKLEDTITLIKGKIEEVHLPVEKV 132 Query: 138 DVIISEWMGYFLLRESMFDSVISARDRWLKPTGVMYPSHARMWLAPIKSNIADRKRNDFD 197 DVIISEWMGYFLL ESM DSV+ A++++L G +YP + L + R Sbjct: 133 DVIISEWMGYFLLFESMLDSVLYAKNKYLAKGGSVYPDICTISLVAVSDVNKHADR---- 188 Query: 198 GAMADWHNFSDEIKSYYGVDMGVLTKPFAEEQEKYYIQTAMWNDLNPQQIIGTPTIVKEM 257 +A W + YG M + K E A+ L+P+ +I P +K + Sbjct: 189 --IAFWDDV-------YGFKMSCMKKAVIPE--------AVVEVLDPKTLISEPCGIKHI 231 Query: 258 DCLTASVSEIEEVRSNVTSVINMEHTRLC-GFGGWFDVQFSGRKEDPAQQEIELTTAPSE 316 DC T S+S++ E S+ T I T +C G+FD+ F E + +T P Sbjct: 232 DCHTTSISDL-EFSSDFTLKI--TRTSMCTAIAGYFDIYF----EKNCHNRVVFSTGPQS 284 Query: 317 QHCTHWGQQVFIMSNPINVEEGDNLNLGLLMSRSKENHRLMEIELNC 363 THW Q VF++ P +V+ G+ L + + ++K++ R + + L Sbjct: 285 TK-THWKQTVFLLEKPFSVKAGEALKGKVTVHKNKKDPRSLTVTLTL 330 >1F3L-A nrPDB Length = 321 Score = 364 bits (935), Expect = e-101, Method: Composition-based stats. Identities = 109/337 (32%), Positives = 182/337 (54%), Gaps = 31/337 (9%) Query: 35 YFCTYSFLYHQKDMLSDRVRMDAYFNAVFQNKHHFEGKTVLDVGTGSGILAIWSAQAGAR 94 YF +Y ++ML D+VR ++Y + ++QN H F+ K VLDVG G+GIL++++A+AGA+ Sbjct: 10 YFSSYGHYGIHEEMLKDKVRTESYRDFIYQNPHIFKDKVVLDVGCGTGILSMFAAKAGAK 69 Query: 95 KVYAVEATKMADHARALVKANNLDHIVEVIEGSVEDISLP-EKVDVIISEWMGYFLLRES 153 KV AV+ +++ A +++ N L+ + +I+G +E++SLP EKVDVIISEWMGYFLL ES Sbjct: 70 KVIAVDQSEILYQAMDIIRLNKLEDTIVLIKGKIEEVSLPVEKVDVIISEWMGYFLLFES 129 Query: 154 MFDSVISARDRWLKPTGVMYPSHARMWLAPIKSNIADRKRNDFDGAMADWHNFSDEIKSY 213 M DSV+ A+ ++L G +YP + L + R +A W + Sbjct: 130 MLDSVLYAKSKYLAKGGSVYPDICTISLVAVSDVSKHADR------IAFWDDV------- 176 Query: 214 YGVDMGVLTKPFAEEQEKYYIQTAMWNDLNPQQIIGTPTIVKEMDCLTASVSEIEEVRSN 273 YG +M + K E A+ ++ + +I P +K +DC T S+S++ E S+ Sbjct: 177 YGFNMSCMKKAVIPE--------AVVEVVDHKTLISDPCDIKHIDCHTTSISDL-EFSSD 227 Query: 274 VTSVINMEHTRLC-GFGGWFDVQFSGRKEDPAQQEIELTTAPSEQHCTHWGQQVFIMSNP 332 T + T +C G+FD+ F E + +T P THW Q +F++ P Sbjct: 228 FT--LRTTKTAMCTAVAGYFDIYF----EKNCHNRVVFSTGPQSTK-THWKQTIFLLEKP 280 Query: 333 INVEEGDNLNLGLLMSRSKENHRLMEIELNCEIKEAS 369 V+ G+ L + + ++K++ R + + L + Sbjct: 281 FPVKAGEALKGKITVHKNKKDPRSLIVTLTLNSSTQT 317 >6CU3-A nrPDB Length = 336 Score = 353 bits (906), Expect = 5e-98, Method: Composition-based stats. Identities = 113/328 (34%), Positives = 182/328 (55%), Gaps = 33/328 (10%) Query: 43 YHQKDMLSDRVRMDAYFNAVFQNKHHFEGKTVLDVGTGSGILAIWSAQAGARKVYAVEAT 102 ++ML D +R +AY NA+ QNKH F+ K VLD+G G+GIL +++A+AGA++V ++ + Sbjct: 24 GIHEEMLKDGIRTNAYKNAILQNKHLFKDKVVLDIGCGTGILCLFAAKAGAKRVIGIDMS 83 Query: 103 KMADHARALVKANNLDHIVEVIEGSVEDIS-LP---EKVDVIISEWMGYFLLRESMFDSV 158 + D AR +V N H++E+I+G VEDI+ LP EKVD+IISEWMGYFLL ESM +V Sbjct: 84 DIIDKARQIVSDNGYSHVIELIKGKVEDIAQLPFGIEKVDIIISEWMGYFLLYESMLQTV 143 Query: 159 ISARDRWLKPTGVMYPSHARMWLAPIKSNIADRKRNDFDGAMADWHNFSDEIKSYYGVDM 218 +SARDRWL+P G ++P M++ I+ + R + DF W N YG + Sbjct: 144 LSARDRWLRPGGYLFPDKCTMYICGIEDSEYKRDKIDF------WDNV-------YGFNF 190 Query: 219 GVLTKPFAEEQEKYYIQTAMWNDLNPQQIIGTPTIVKEMDCLTASVSEIEEVRSNVTSVI 278 + E ++++ QQII T + E+D T +++++ ++ Sbjct: 191 SAIKADALREPLVDFVES--------QQIITTQSKFLEIDLNTIQPEDLKQITTSF--EF 240 Query: 279 NMEHTRLC-GFGGWFDVQFSGRKEDPAQQEIELTTAPSEQHCTHWGQQVFIMSNPINVEE 337 ++ C F WFD FS + +E +T P + THW Q VF + N + ++ Sbjct: 241 TSQYQEYCQAFVAWFDCVFSRG----PHKPVEFSTGPFTEG-THWKQTVFYLENDLPLKP 295 Query: 338 GDNLNLGLLMSRSKENHRLMEIELNCEI 365 D + + +S++K NHR ++I + + Sbjct: 296 NDVIKGTITISQNKSNHRDLDISMKYTV 323 >1G6Q-1 nrPDB Length = 328 Score = 352 bits (903), Expect = 2e-97, Method: Composition-based stats. Identities = 103/338 (30%), Positives = 174/338 (51%), Gaps = 29/338 (8%) Query: 34 QYFCTYSFLYHQKDMLSDRVRMDAYFNAVFQNKHHFEGKTVLDVGTGSGILAIWSAQAGA 93 YF +Y ++ML D VR +Y NA+ QNK F+ K VLDVG G+GIL++++A+ GA Sbjct: 2 YYFDSYDHYGIHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGA 61 Query: 94 RKVYAVEATKMADHARALVKANNLDHIVEVIEGSVEDISLP-EKVDVIISEWMGYFLLRE 152 + V V+ + + + A+ LV+ N + ++ G +ED+ LP KVD+IISEWMGYFLL E Sbjct: 62 KHVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLEDVHLPFPKVDIIISEWMGYFLLYE 121 Query: 153 SMFDSVISARDRWLKPTGVMYPSHARMWLAPIKSNIADRKRNDFDGAMADWHNFSDEIKS 212 SM D+V+ ARD +L G+++P + LA ++ + ++ ++ W + Sbjct: 122 SMMDTVLYARDHYLVEGGLIFPDKCSIHLAGLEDSQYKDEKLNY------WQDV------ 169 Query: 213 YYGVDMGVLTKPFAEEQEKYYIQTAMWNDLNPQQIIGTPTIVKEMDCLTASVSEIEEVRS 272 YG D E ++ N T + E D T +S++ +S Sbjct: 170 -YGFDYSPFVPLVLHEPIVDTVERNNVN--------TTSDKLIEFDLNTVKISDL-AFKS 219 Query: 273 NVTSVINMEHTRLCGFGGWFDVQFSGRKEDPAQQEIELTTAPSEQHCTHWGQQVFIMSNP 332 N + G WFD+ F K ++ +E +T P + THW Q +F + Sbjct: 220 NFKLT-AKRQDMINGIVTWFDIVFPAPK---GKRPVEFSTGPHAPY-THWKQTIFYFPDD 274 Query: 333 INVEEGDNLNLGLLMSRSKENHRLMEIELNCEIKEASG 370 ++ E GD + L+ S +++N+R + I+++ + E++G Sbjct: 275 LDAETGDTIEGELVCSPNEKNNRDLNIKISYKF-ESNG 311 >5IS8-A nrPDB Length = 381 Score = 320 bits (819), Expect = 8e-88, Method: Composition-based stats. Identities = 122/359 (33%), Positives = 186/359 (51%), Gaps = 23/359 (6%) Query: 24 APVDKEVDYAQYFCTYSFLYHQKDMLSDRVRMDAYFNAVFQNKHHFEGKTVLDVGTGSGI 83 + +E QYF Y +L Q++M+ D VR Y A+ QN F+ K VLDVG GSGI Sbjct: 13 SERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSGI 72 Query: 84 LAIWSAQAGARKVYAVEATKMADHARALVKANNLDHIVEVIEGSVEDISLPEKVDVIISE 143 L+ ++AQAGARK+YAVEA+ MA HA LVK+NNL + VI G VE++SLPE+VD+IISE Sbjct: 73 LSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDIIISE 132 Query: 144 WMGYFLLRESMFDSVISARDRWLKPTGVMYPSHARMWLAPIKSNIADRKRNDFDGAMADW 203 MGY L E M +S + A+ ++LKP+G M+P+ + LAP + W Sbjct: 133 PMGYMLFNERMLESYLHAK-KYLKPSGNMFPTIGDVHLAPFTDEQL---YMEQFTKANFW 188 Query: 204 HNFSDEIKSYYGVDMGVLTKPFAEEQEKYYIQTAMWNDLNPQQIIGTPTIVKEMDCLTAS 263 + S++GVD+ L +E Y+ Q + D +I+ ++ ++ L A Sbjct: 189 YQ-----PSFHGVDLSALRGAAVDE---YFRQPVV--DTFDIRILMAKSVKYTVNFLEAK 238 Query: 264 VSEIEEVRSNVTSVINMEHTRL-CGFGGWFDVQFSGRKEDPAQQEIELTTAPSEQHCTHW 322 ++ + + +M H+ L G WFDV F G + + L+TAP+E THW Sbjct: 239 EGDLHRI--EIPFKFHMLHSGLVHGLAFWFDVAFIG-----SIMTVWLSTAPTEP-LTHW 290 Query: 323 GQQVFIMSNPINVEEGDNLNLGLLMSRSKENHRLMEIELNCEIKEASGNPKESFKKTYF 381 Q + +P+ + GD L+ L+ +K + I + + + K +F Sbjct: 291 YQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFF 349 >3B3J-A nrPDB Length = 480 Score = 320 bits (819), Expect = 8e-88, Method: Composition-based stats. Identities = 122/359 (33%), Positives = 186/359 (51%), Gaps = 23/359 (6%) Query: 24 APVDKEVDYAQYFCTYSFLYHQKDMLSDRVRMDAYFNAVFQNKHHFEGKTVLDVGTGSGI 83 + +E QYF Y +L Q++M+ D VR Y A+ QN F+ K VLDVG GSGI Sbjct: 112 SERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSGI 171 Query: 84 LAIWSAQAGARKVYAVEATKMADHARALVKANNLDHIVEVIEGSVEDISLPEKVDVIISE 143 L+ ++AQAGARK+YAVEA+ MA HA LVK+NNL + VI G VE++SLPE+VD+IISE Sbjct: 172 LSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDIIISE 231 Query: 144 WMGYFLLRESMFDSVISARDRWLKPTGVMYPSHARMWLAPIKSNIADRKRNDFDGAMADW 203 MGY L E M +S + A+ ++LKP+G M+P+ + LAP + W Sbjct: 232 PMGYMLFNERMLESYLHAK-KYLKPSGNMFPTIGDVHLAPFTDEQL---YMEQFTKANFW 287 Query: 204 HNFSDEIKSYYGVDMGVLTKPFAEEQEKYYIQTAMWNDLNPQQIIGTPTIVKEMDCLTAS 263 + S++GVD+ L +E Y+ Q + D +I+ ++ ++ L A Sbjct: 288 YQ-----PSFHGVDLSALRGAAVDE---YFRQPVV--DTFDIRILMAKSVKYTVNFLEAK 337 Query: 264 VSEIEEVRSNVTSVINMEHTRL-CGFGGWFDVQFSGRKEDPAQQEIELTTAPSEQHCTHW 322 ++ + + +M H+ L G WFDV F G + + L+TAP+E THW Sbjct: 338 EGDLHRI--EIPFKFHMLHSGLVHGLAFWFDVAFIG-----SIMTVWLSTAPTEP-LTHW 389 Query: 323 GQQVFIMSNPINVEEGDNLNLGLLMSRSKENHRLMEIELNCEIKEASGNPKESFKKTYF 381 Q + +P+ + GD L+ L+ +K + I + + + K +F Sbjct: 390 YQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFF 448 >4IKP-A nrPDB Length = 341 Score = 320 bits (819), Expect = 8e-88, Method: Composition-based stats. Identities = 122/355 (34%), Positives = 185/355 (52%), Gaps = 23/355 (6%) Query: 28 KEVDYAQYFCTYSFLYHQKDMLSDRVRMDAYFNAVFQNKHHFEGKTVLDVGTGSGILAIW 87 +E QYF Y +L Q++M+ D VR Y A+ QN F+ K VLDVG GSGIL+ + Sbjct: 3 EESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSGILSFF 62 Query: 88 SAQAGARKVYAVEATKMADHARALVKANNLDHIVEVIEGSVEDISLPEKVDVIISEWMGY 147 +AQAGARK+YAVEA+ MA HA LVK+NNL + VI G VE++SLPE+VD+IISE MGY Sbjct: 63 AAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDIIISEPMGY 122 Query: 148 FLLRESMFDSVISARDRWLKPTGVMYPSHARMWLAPIKSNIADRKRNDFDGAMADWHNFS 207 L E M +S + A+ ++LKP+G M+P+ + LAP + W+ Sbjct: 123 MLFNERMLESYLHAK-KYLKPSGNMFPTIGDVHLAPFTDEQL---YMEQFTKANFWYQ-- 176 Query: 208 DEIKSYYGVDMGVLTKPFAEEQEKYYIQTAMWNDLNPQQIIGTPTIVKEMDCLTASVSEI 267 S++GVD+ L +E Y+ Q + D +I+ ++ ++ L A ++ Sbjct: 177 ---PSFHGVDLSALRGAAVDE---YFRQPVV--DTFDIRILMAKSVKYTVNFLEAKEGDL 228 Query: 268 EEVRSNVTSVINMEHTRL-CGFGGWFDVQFSGRKEDPAQQEIELTTAPSEQHCTHWGQQV 326 + + +M H+ L G WFDV F G + + L+TAP+E THW Q Sbjct: 229 HRI--EIPFKFHMLHSGLVHGLAFWFDVAFIG-----SIMTVWLSTAPTEP-LTHWYQVR 280 Query: 327 FIMSNPINVEEGDNLNLGLLMSRSKENHRLMEIELNCEIKEASGNPKESFKKTYF 381 + +P+ + GD L+ L+ +K + I + + + K +F Sbjct: 281 CLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFF 335 >4LWO-B nrPDB Length = 368 Score = 269 bits (686), Expect = 2e-72, Method: Composition-based stats. Identities = 102/394 (25%), Positives = 168/394 (42%), Gaps = 76/394 (19%) Query: 21 GPSAPVDKEVD-----YAQYFCTYSFLYHQKDMLSDRVRMDAYFNAVFQNKHHFEGKTVL 75 S ++ D + QY+ +YS L + ML D RM Y ++ Q+ EGK V+ Sbjct: 1 MESGGFAEDYDPNSSLHHQYYESYSDLAVHRLMLEDAQRMSFYRKSIEQS-ASIEGKVVV 59 Query: 76 DVGTGSGILAIWSAQAGARKVYAVEATKMADHARALVKANNLDHIVEV--------IEGS 127 DVG+G+GIL++W+A+AGA+ V+++EA+ +++ +V+ N+L + V I G Sbjct: 60 DVGSGTGILSMWAARAGAKHVFSIEASSLSEFQIGVVEDNDLSTKITVLGDTVENIIAGG 119 Query: 128 VEDISLPEK-------VDVIISEWMGYFLLRESMFDSVISARDRW---------LKPTGV 171 V + K V V++SEWMG++L E M SVI AR+ + L+P Sbjct: 120 VANFVNRHKAKLGKCGVAVLLSEWMGFYLFHEGMLPSVIRARNFFQDVNAALGVLQPIE- 178 Query: 172 MYPSHARMWLAPIKSNIADRKRNDFDGAMADWHNFSDEIKSYYGVDMGVLTKPFAEEQEK 231 M P A +++API +R D +FS + Y V + EQ Sbjct: 179 MIPERATVFVAPITCKPYYVQRYKNFWRDVDGLDFSRYGRIEYEVYL---------EQAS 229 Query: 232 YYIQTAMWNDLNPQQIIGTPTIVKEMDCLTASVSEIEEVRSNVTSVIN-----MEHTR-- 284 ++ L P ++ + E++ T + + + V + +H R Sbjct: 230 PLVEC-----LPPLCLLHEGLSLIELNLSTVQEEVLTSLHNTVHFDLKESAEFQQHAREA 284 Query: 285 -------LCGFGGWFDVQFSGRKEDPAQQEIELTTAPSEQHCTHWGQQVFIMSNPINVE- 336 + GF WFDV + L+T+P THW Q ++ E Sbjct: 285 GSEGRVSVDGFTVWFDVSYGAH---------TLSTSPRSP-STHWKQTTILLPREARNEE 334 Query: 337 ------EGDNLNLGLLMSRSKENHRLMEIELNCE 364 EG L + + +S S + R IEL + Sbjct: 335 LVSFPVEGGELGVEMHISASDKTLRFYTIELELK 368 >5FA5-A nrPDB Length = 650 Score = 223 bits (569), Expect = 6e-59, Method: Composition-based stats. Identities = 70/323 (21%), Positives = 119/323 (36%), Gaps = 61/323 (18%) Query: 50 SDRVRMDAYFNAVF--------QNKHHFEGKTVLDVGTGSGILAIWSAQAGAR-----KV 96 D ++ Y A++ + + + ++ +G G G L S +A + K+ Sbjct: 342 KDPIKYSQYQQAIYKCLLDRVPEEEKDTNVQVLMVLGAGRGPLVNASLRAAKQADRRIKL 401 Query: 97 YAVEATKMADHARALVKANNLDHIVEVIEGSVEDISLPEKVDVIISEWMGYFLLRESMFD 156 YAVE A + V V+ + + PEK D+I+SE +G F E + Sbjct: 402 YAVEKNPNAVVTLENWQFEEWGSQVTVVSSDMREWVAPEKADIIVSELLGSFADNE-LSP 460 Query: 157 SVISARDRWLKPTGVMYPSHARMWLAPIKSNIADRKRNDFDGAMADWHNFSDEIKSYYGV 216 + +LK GV P +LAPI S+ +E+++ Sbjct: 461 ECLDGAQHFLKDDGVSIPGEYTSFLAPISSS-----------------KLYNEVRACREK 503 Query: 217 DMGVLTKPFAEEQEKYYIQTAMWNDLNPQQIIGTPTIVKEMDCLTASVSEIEEVRSN--- 273 D P A+ + Y ++ ++ L+ Q C T S + + N Sbjct: 504 D----RDPEAQFEMPYVVRLHNFHQLSAPQ-----------PCFTFSHPNRDPMIDNNRY 548 Query: 274 VTSVINME-HTRLCGFGGWFDVQFSGRKEDPAQQEIELTTAP--SEQHCTHWGQQVFIMS 330 T +E +T L GF G+F+ Q+I L+ P W +F + Sbjct: 549 CTLEFPVEVNTVLHGFAGYFETVL--------YQDITLSIRPETHSPGMFSWFPILFPIK 600 Query: 331 NPINVEEGDNLNLGL-LMSRSKE 352 PI V EG + + S SK+ Sbjct: 601 QPITVREGQTICVRFWRCSNSKK 623 >4G56-A nrPDB Length = 657 Score = 214 bits (544), Expect = 6e-56, Method: Composition-based stats. Identities = 66/311 (21%), Positives = 115/311 (36%), Gaps = 60/311 (19%) Query: 50 SDRVRMDAYFNAVF--------QNKHHFEGKTVLDVGTGSGILAIWSAQAGAR-----KV 96 D V+ Y AV+ + + + ++ +G G G L S +A + KV Sbjct: 349 KDPVKYSQYQQAVYKCLLDRVPEEEKETNIQILMVLGAGRGPLVNASLRAAKQAERKIKV 408 Query: 97 YAVEATKMADHARALVKANNLDHIVEVIEGSVEDISLPEKVDVIISEWMGYFLLRESMFD 156 YAVE A + V V+ G + + PEK D+I+SE +G F E + Sbjct: 409 YAVEKNPNAVITLEGWRYEEWGSQVTVVSGDMREWKAPEKADIIVSELLGSFGDNE-LSP 467 Query: 157 SVISARDRWLKPTGVMYPSHARMWLAPIKSNIADRKRNDFDGAMADWHNFSDEIKSYYGV 216 + +LK GV P +LAPI S+ +E+++ Sbjct: 468 ECLDGAQHFLKDDGVSIPGEYTSYLAPISSS-----------------KLYNEVRACREK 510 Query: 217 DMGVLTKPFAEEQEKYYIQTAMWNDLNPQQIIGTPTIVKEMDCLTASVSEIEEVRSN--- 273 D P A+ + Y ++ ++ L+ + C T ++V N Sbjct: 511 D----RDPEAQFEMPYVVRLHNFHQLSDP-----------LPCFTFHHPNKDDVIDNNRY 555 Query: 274 VTSVINME-HTRLCGFGGWFDVQFSGRKEDPAQQEIELTTAP--SEQHCTHWGQQVFIMS 330 ++ +T L GF G+F+ +++ L+ P W +F + Sbjct: 556 CCLQYRVDLNTVLHGFAGYFNTVL--------YKDVTLSICPESHSPGMFSWFPILFPIK 607 Query: 331 NPINVEEGDNL 341 PI + EGD + Sbjct: 608 QPIPMREGDTV 618 >6OGN-A nrPDB Length = 692 Score = 203 bits (516), Expect = 1e-52, Method: Composition-based stats. Identities = 71/343 (20%), Positives = 127/343 (37%), Gaps = 34/343 (9%) Query: 12 GRAAGTGGGGPSAPVDKEVDYAQYFCTYSFLYHQKDMLSDRVRMDAYFNAV----FQNKH 67 GRA T G D+ DY Q S+ DML D+ R Y+ + + K Sbjct: 6 GRANPTTGSLEWLEEDEHYDYHQEIARSSY----ADMLHDKDRNIKYYQGIRAAVSRVKD 61 Query: 68 HFEGKTVLDVGTGSGILAIWSAQAGARKVYAVEAT-KMADHARALVKANNLDHIVEVIEG 126 + VLD+GTG+G+L++ + AGA YA+E MA+ A +V+ N ++VI Sbjct: 62 RGQKALVLDIGTGTGLLSMMAVTAGADFCYAIEVFKPMAEAAVKIVERNGFSDKIKVINK 121 Query: 127 SVEDIS------LPEKVDVIISEWMGYFLLRESMFDSVISARDRWLKPTGVMYPSHARMW 180 +++ LP + +++I+E L+ E S A ++ P A ++ Sbjct: 122 HSTEVTVGPDGDLPCRANILITELFDTELIGEGALPSYEHAHKHLVQEDCEAVPHRATVY 181 Query: 181 LAPIKSNIADRKRNDFDGAMADWHN-FSDEIKSYYGVDMGVLTKPFAEEQEKYYIQTAMW 239 ++S M W+ F +++ G + V + Sbjct: 182 AQLVES-----------RRMWSWNKLFPVRVRTSLGEQVIVPPSELERCPGAPSVCDIQL 230 Query: 240 NDLNPQQIIGTPTIVKEMDCLTASVSEIEEVRSNVTSV--INMEHTRLCGFGGWFDVQF- 296 N ++P + + + S+ + S + + + W+D++ Sbjct: 231 NQVSPADFTVLSDV---LPMFSVDFSKQVSSSAACHSRQFVPLASGQAQVVLSWWDIEMD 287 Query: 297 SGRKEDPAQQEIELTTAPSE-QHCTHWGQQVFIMSNPINVEEG 338 K T P E Q HW Q V+ + V +G Sbjct: 288 PEGKIKCTMAPFWAQTDPQELQWRDHWMQCVYFLPQEEPVVQG 330 >3X0D-A nrPDB Length = 655 Score = 176 bits (447), Expect = 1e-44, Method: Composition-based stats. Identities = 67/341 (19%), Positives = 121/341 (35%), Gaps = 39/341 (11%) Query: 15 AGTGGGGPSAPVDKEVDYAQYFCTYSFLYHQKDMLSDRVRMDAY----FNAVFQNKH-HF 69 G +++ D AQ F DM+ D R D + + + KH + Sbjct: 15 NQKTGEREWVVAEEDYDMAQELARSRF----GDMILDFDRNDKFLAGLKTTIAEKKHENT 70 Query: 70 EGKT-VLDVGTGSGILAIWSAQAGARKVYAVEAT-KMADHARALVKANNLDHIVEVIEGS 127 +GK VLD+GTG+G+L++ +A+ GA KV A+E M D AR + + + VI Sbjct: 71 DGKVHVLDIGTGTGLLSLMAAREGADKVTALEVFKPMGDCARHITSNSPWSDKITVISER 130 Query: 128 VEDISL--PEKVDVIISEWMGYFLLRESMFDSVISARDRWLKPTGVMYPSHARMWLAPIK 185 D+S + D+I++E L+ E + A +R KP + PS +++ P++ Sbjct: 131 STDVSQIGGSRADIIVAEVFDTELIGEGALRTFKEALERLAKPGCRVVPSTGNVYIVPVE 190 Query: 186 SNIADRKRNDFDGAMADWH----NFSDEIKSYYGVDMGVLTKPFAEEQEKYYIQTAMWND 241 S++ + ND + + + V + + E Sbjct: 191 SHLL-KMFNDIPRLNGEKDEEPLGRCSGTAAVFDVQLSEMKTHEFRE------------- 236 Query: 242 LNPQQIIGTPTIVKEMDCLTASVSEIEEVRSNVTSVINMEHTRLCGFGGWFDVQFSGRKE 301 + P + + D +I S V + + W+D+ Sbjct: 237 ------LSEPIVAFKFDFE--HEEKIIFDESFVREAVAHSSGTIDALLMWWDIDMDRNGT 288 Query: 302 DPAQQEIELTTAPSEQHCTHWGQQVFIMSNPINVEEGDNLN 342 + + HW Q V+ + VE Sbjct: 289 TFIDMGPKWKNKNNYAWRDHWMQAVYYLPEKKKVEMNQTFE 329 >5EKU-A nrPDB Length = 390 Score = 170 bits (431), Expect = 7e-43, Method: Composition-based stats. Identities = 69/295 (23%), Positives = 129/295 (43%), Gaps = 37/295 (12%) Query: 45 QKDMLSDRVRMDAYFNAVFQNKHHFEGKTVLDVGTGSGILAIWSAQAGARKVYAVEATK- 103 M++D R + Y+ + KH VL++G GSG+L++ +A+ GA+ V AVE ++ Sbjct: 72 HYAMMNDEERNNFYYEVL--KKHVTPETGVLEIGAGSGLLSLMAAKLGAKWVVAVEGSEE 129 Query: 104 MADHARALVKANNLDHIVEVIEGSVEDI---SLPEKVDVIISEWMGYFLLRESMFDSVIS 160 +A AR ++ANN++H V+V+ ++ LPE DV++SE G +L ES D V+ Sbjct: 130 LAKLARENIRANNMEHQVKVLHMMSTELKPKHLPEPPDVLLSEIFGTMMLGESALDYVVD 189 Query: 161 ARDRWLKPTGVMYPSHARMWLAPIKSNIADRKRNDFDGAMADWHNFSDEIKSYYGVDMGV 220 R+R LKPT + P + PI+ + R +++ W + + M + Sbjct: 190 VRNRLLKPTTKIIPQFGTQYAVPIECDALHR-----ISSVSGWRDLDLKHM------MTL 238 Query: 221 LTKPFAEEQEKYYIQTAMWNDLNPQQIIGTPTIVKEMDCLTASVSEIEEVRSNVTSVINM 280 + Y I+ N + + P + +D +++ ++I + V+ Sbjct: 239 QDTVSIVFAKHYGIRMNSVNF----RRLSDPIELFRVDFSSSNRNDISRRKHF--DVVAK 292 Query: 281 EHTRLCGFGGWFDVQFSGRKEDPAQQEIELTTAPSE-----QHCTHWGQQVFIMS 330 E ++ V E ++T P + WGQ + ++ Sbjct: 293 ESGTAHAMLFYWKVT---------DDEFVMSTDPEDTVNNFPRDMQWGQALQLLD 338 >4M36-A nrPDB Length = 343 Score = 170 bits (431), Expect = 8e-43, Method: Composition-based stats. Identities = 69/295 (23%), Positives = 129/295 (43%), Gaps = 37/295 (12%) Query: 45 QKDMLSDRVRMDAYFNAVFQNKHHFEGKTVLDVGTGSGILAIWSAQAGARKVYAVEATK- 103 M++D R + Y+ + KH VL++G GSG+L++ +A+ GA+ V AVE ++ Sbjct: 37 HYAMMNDEERNNFYYEVL--KKHVTPETGVLEIGAGSGLLSLMAAKLGAKWVVAVEGSEE 94 Query: 104 MADHARALVKANNLDHIVEVIEGSVEDI---SLPEKVDVIISEWMGYFLLRESMFDSVIS 160 +A AR ++ANN++H V+V+ ++ LPE DV++SE G +L ES D V+ Sbjct: 95 LAKLARENIRANNMEHQVKVLHMMSTELKSKHLPEPPDVLLSEIFGTMMLGESALDYVVD 154 Query: 161 ARDRWLKPTGVMYPSHARMWLAPIKSNIADRKRNDFDGAMADWHNFSDEIKSYYGVDMGV 220 R+R LKPT + P + PI+ + R +++ W + + M + Sbjct: 155 VRNRLLKPTTKIIPQFGTQYAVPIECDALHR-----ISSVSGWRDLDLKHM------MTL 203 Query: 221 LTKPFAEEQEKYYIQTAMWNDLNPQQIIGTPTIVKEMDCLTASVSEIEEVRSNVTSVINM 280 + Y I+ N + + P + +D +++ ++I + V+ Sbjct: 204 QDTVSIVFAKHYGIRMNSVNF----RRLSDPIELFRVDFSSSNRNDIPRRKHF--DVVAK 257 Query: 281 EHTRLCGFGGWFDVQFSGRKEDPAQQEIELTTAPSE-----QHCTHWGQQVFIMS 330 E ++ V E ++T P + WGQ + ++ Sbjct: 258 ESGTAHAMLFYWKVT---------DDEFVMSTDPEDTVNNFPRDMQWGQALQLLD 303 >3UA4-A nrPDB Length = 745 Score = 113 bits (281), Expect = 2e-25, Method: Composition-based stats. Identities = 56/328 (17%), Positives = 104/328 (31%), Gaps = 47/328 (14%) Query: 50 SDRVRMDAYFNAVFQNKHHF-----EGKTVLDVGTGSGILAIWSAQAGAR---------- 94 D+++ D Y AV + + +G G G + ++ Sbjct: 384 QDQIKYDVYGEAVVGALKDLGADGRKTVVIYLLGGGRGPIGTKILKSEREYNNTFRQGQE 443 Query: 95 ----KVYAVEATKMADHARALVKANNLDHIVEVIEGSVEDISLP--------EKVDVIIS 142 K+Y VE A + V +IE + SLP E+ D+I+S Sbjct: 444 SLKVKLYIVEKNPNAIVTLKYMNVRTWKRRVTIIESDMR--SLPGIAKDRGFEQPDIIVS 501 Query: 143 EWMGYFLLRESMFDSVISARDRWLKPTGVMYPSHARMWLAPIKSNIADRKRNDFDGAMAD 202 E +G F E + + +LKPT + P ++ PI S + Sbjct: 502 ELLGSFGDNE-LSPECLDGVTGFLKPTTISIPQKYTSYVKPIMSTHIHQTIKAQSIPYLS 560 Query: 203 WHNFSDEIKSYYGVDMGVLTKPFAEEQEKYYIQTAMWNDLNPQQIIGTPTIVKEMDCLTA 262 + +D + + ++ + +++ M P T Sbjct: 561 -RAIPSHGRGEPELDEDEM---WIQKYPQGHVRNNMDQIYVVYLSKYIPLAETTKPVFTF 616 Query: 263 SVSEIEEVRSNVTSVINM---EHTRLCGFGGWFDVQFSGRKEDPAQQEIELTTAP--SEQ 317 + + I + L GF G+FD+Q + + L+ P Sbjct: 617 EHPNFMNSSNERSDSIEFVMDRNADLMGFAGYFDLQL--------YKTVMLSIEPSTHTP 668 Query: 318 HCTHWGQQVFIMSNPINVEEGDNLNLGL 345 W V + + + V EGD ++L + Sbjct: 669 GMVSWFPAVIPLRDQLRVGEGDRISLKI 696 >1WY7-A nrPDB Length = 207 Score = 51.4 bits (121), Expect = 6e-07, Method: Composition-based stats. Identities = 22/74 (29%), Positives = 36/74 (48%), Gaps = 3/74 (4%) Query: 68 HFEGKTVLDVGTGSGILAIWSAQAGARKVYAVEATKMADHARALVKANNLDHIVEVIEGS 127 EGK V D+G G+G+L+ + GA++V VE K A + +V G Sbjct: 47 DIEGKVVADLGAGTGVLSYGALLLGAKEVICVEVDKEAVDVL-IENLGEFKGKFKVFIGD 105 Query: 128 VEDISLPEKVDVII 141 V + + +VD++I Sbjct: 106 VSEFN--SRVDIVI 117 >1L3B-A nrPDB Length = 192 Score = 50.2 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 23/105 (21%), Positives = 44/105 (41%), Gaps = 7/105 (6%) Query: 70 EGKTVLDVGTGSGILAIWSAQAGARKVYAVEATKMADHARA-LVKANNLDHIVEVIEGSV 128 + +DVG G+G + + A R+VYA++ A ++ + L V ++EG Sbjct: 33 KNDVAVDVGCGTGGVTLELA-GRVRRVYAIDRNPEAISTTEMNLQRHGLGDNVTLMEGDA 91 Query: 129 EDISLPEKVDVIISEWMGYFLLRESMFDSVISARDRWLKPTGVMY 173 + +L + D+ I+ G ++ LKP G + Sbjct: 92 PE-ALCKIPDIDIAVVGGSG----GELQEILRIIKDKLKPGGRII 131 >2AS0-A nrPDB Length = 396 Score = 48.7 bits (114), Expect = 4e-06, Method: Composition-based stats. Identities = 30/121 (24%), Positives = 54/121 (44%), Gaps = 14/121 (11%) Query: 74 VLDVGTGSGILAIWSAQAGARKVYAVEATKMA-DHARALVKANNLDHIVEVIEGSV-EDI 131 VLDV T +G AI +A AGA +V ++ + A + A+ K N ++ ++ I GS E++ Sbjct: 221 VLDVFTYTGGFAIHAAIAGADEVIGIDKSPRAIETAKENAKLNGVEDRMKFIVGSAFEEM 280 Query: 132 S----LPEKVDVIISEWMGYFLLRESMFDS-------VISARDRWLKPTGVMYPSHARMW 180 EK D+++ + F+ E + V A +K G++ Sbjct: 281 EKLQKKGEKFDIVVLDP-PAFVQHEKDLKAGLRAYFNVNFAGLNLVKDGGILVTCSCSQH 339 Query: 181 L 181 + Sbjct: 340 V 340 >3DLC-A nrPDB Length = 219 Score = 47.5 bits (111), Expect = 8e-06, Method: Composition-based stats. Identities = 28/111 (25%), Positives = 53/111 (47%), Gaps = 5/111 (4%) Query: 65 NKHHFEGKTVLDVGTGSGILAIWSAQAGARKVYAVEATK-MADHARALVKANNLDHIVEV 123 N+ T +D+G+G G L+I A+ + A++ +K M + A + NL+ +++ Sbjct: 38 NRFGITAGTCIDIGSGPGALSIALAKQSDFSIRALDFSKHMNEIALKNIADANLNDRIQI 97 Query: 124 IEGSVEDISLPEK-VDVIISEWMGYFLLRESMFDSVISARDRWLKPTGVMY 173 ++G V +I + + D+I+S G E + + R LK G Y Sbjct: 98 VQGDVHNIPIEDNYADLIVSR--GSVFFWEDVATAFREIY-RILKSGGKTY 145 >3SVZ-A nrPDB Length = 263 Score = 47.5 bits (111), Expect = 9e-06, Method: Composition-based stats. Identities = 30/145 (20%), Positives = 60/145 (41%), Gaps = 8/145 (5%) Query: 56 DAYFNAVFQNKHHFEGKTVLDVGTGSGILAIWSAQAGARKVYAVEATK--MADHARALVK 113 +A AV + + D+G G+G ++ A ++ ++ + VK Sbjct: 38 EATRKAVSFINELTDDAKIADIGCGTGGQTLFLADYVKGQITGIDLFPDFIEIFNENAVK 97 Query: 114 ANNLDHIVEVIEGSVEDIS-LPEKVDVIISEWMGYFLLRESMFDSVISARDRWLKPTGVM 172 AN V+ I GS++++ E++D+I SE Y + E + ++LK G + Sbjct: 98 AN-CADRVKGITGSMDNLPFQNEELDLIWSEGAIYNIGFERGMNEW----SKYLKKGGFI 152 Query: 173 YPSHARMWLAPIKSNIADRKRNDFD 197 S A + + + I D + + Sbjct: 153 AVSEASWFTSERPAEIEDFWMDAYP 177 >5Z9O-A nrPDB Length = 399 Score = 46.8 bits (109), Expect = 2e-05, Method: Composition-based stats. Identities = 34/189 (17%), Positives = 66/189 (34%), Gaps = 33/189 (17%) Query: 62 VFQNKHHFEGKTVLDVGTGSGILAIWSAQAGARKVYAVEAT-KMADHARALVKANNLDHI 120 + H +GKT+LD+G G G L + +A+ KV V + + + + L+ + Sbjct: 157 ILNKLHPEKGKTLLDIGCGWGTLMLTAAKEYGLKVTGVTLSEEQYKLVQKKIYDEGLEDV 216 Query: 121 VEVIEGSVEDISLPEKVDVIISEWMGYFLLRESMFDSVISARDRWLKPTGV--------- 171 EV ++ ++ D + S M + E++ + ++LK GV Sbjct: 217 AEVKLEDYRELG-DQQWDYVTSVGMFEHVGSENLGEYFKDVA-KYLKNDGVALIHGITRQ 274 Query: 172 ------------MYPSHARMWLAPIKSNIADRK---------RNDFDGAMADWHNFSDEI 210 ++P L I S I + R + + W + Sbjct: 275 QGGATNAWINKYIFPGGYIPGLVEIISRIEEANLQVSDVEMLRRHYQRTLEIWDKNFNNA 334 Query: 211 KSYYGVDMG 219 + +MG Sbjct: 335 RPEIEKNMG 343 >3LPM-A nrPDB Length = 259 Score = 45.2 bits (105), Expect = 5e-05, Method: Composition-based stats. Identities = 21/75 (28%), Positives = 41/75 (54%), Gaps = 5/75 (6%) Query: 70 EGKTVLDVGTGSGILAIWSAQAGARKVYAVEATK-MADHARALVKANNLDHIVEVIE--- 125 +GK + D+ +G+GI+ + + K+ VE + +AD A+ V N L+ +E+IE Sbjct: 50 KGKII-DLCSGNGIIPLLLSTRTKAKIVGVEIQERLADMAKRSVAYNQLEDQIEIIEYDL 108 Query: 126 GSVEDISLPEKVDVI 140 + D+ E+ D++ Sbjct: 109 KKITDLIPKERADIV 123 >5JE5-A nrPDB Length = 247 Score = 44.8 bits (104), Expect = 6e-05, Method: Composition-based stats. Identities = 25/115 (21%), Positives = 45/115 (39%), Gaps = 3/115 (2%) Query: 60 NAVFQNKHHFEGKTVLDVGTGSGILAIWSAQAGARKVYAVEAT-KMADHARALVKANNLD 118 +F GK+VLD+ G G + GA KV V+ + KM + AR ++ Sbjct: 31 RTIFHMIGDVSGKSVLDLACGFGFFGREIYRRGAAKVVGVDISEKMIELARE--ESRKYG 88 Query: 119 HIVEVIEGSVEDISLPEKVDVIISEWMGYFLLRESMFDSVISARDRWLKPTGVMY 173 +E V ++ + D++ + W+ + + LKP G + Sbjct: 89 DPLEFHVRDVANMEPLGQFDLVNAAWLFNYADSVENLRKMFKVVRASLKPDGKLV 143 >2ZZN-A nrPDB Length = 336 Score = 44.5 bits (103), Expect = 8e-05, Method: Composition-based stats. Identities = 16/60 (26%), Positives = 30/60 (50%), Gaps = 3/60 (5%) Query: 73 TVLDVGTGSGILAIWSAQAGARKVYAVEATKMA-DHARALVKANNLDHIVEVIEGSVEDI 131 V+D+ G G +I A +K+YA++ A + + +K N L+H + I V ++ Sbjct: 198 VVVDMFAGVGPFSIACKNA--KKIYAIDINPHAIELLKKNIKLNKLEHKIIPILSDVREV 255 >3D2L-A nrPDB Length = 243 Score = 44.5 bits (103), Expect = 9e-05, Method: Composition-based stats. Identities = 26/144 (18%), Positives = 53/144 (36%), Gaps = 13/144 (9%) Query: 41 FLYHQKDMLSDRVRMDAYFNAVFQNKHHFEGKTVLDVGTGSGILAIWSAQAGARKVYAVE 100 F Y +++ D + + Q + GK + D+G G+G + A Y V Sbjct: 7 FAYVYDELMQDVPYPEWVAWVLEQVE---PGKRIADIGCGTGTATLLLADH-----YEVT 58 Query: 101 ATKMADHARALVKANNLDHIVEV--IEGSVEDISLPEKVDV--IISEWMGYFLLRESMFD 156 +++ + + ++ V + ++ LPE VD I+ + + Y L E+ Sbjct: 59 GVDLSEEMLEIAQEKAMETNRHVDFWVQDMRELELPEPVDAITILCDSLNY-LQTEADVK 117 Query: 157 SVISARDRWLKPTGVMYPSHARMW 180 + R L G + + Sbjct: 118 QTFDSAARLLTDGGKLLFDVHSPY 141 >4KDR-A nrPDB Length = 223 Score = 43.3 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 32/116 (27%), Positives = 52/116 (44%), Gaps = 11/116 (9%) Query: 62 VFQNKHHFEGKTVLDVGTGSGILAIWSAQAGARKVYAVEATKMADHARALVKANNLDHIV 121 + + GK VLDVG G GILA A+ GA V M + K + L+ + Sbjct: 54 IAERAGGLFGKKVLDVGCGGGILAESMAREGA----TVTGLDMGFEPLQVAKLHALESGI 109 Query: 122 EV--IEGSVEDISLPE--KVDVIISEWMGYFLLRESMFDSVISARDRWLKPTGVMY 173 +V ++ +VE+ + + DV+ M L SV+ A + +KP G ++ Sbjct: 110 QVDYVQETVEEHAAKHAGQYDVVTCMEM---LEHVPDPQSVVRACAQLVKPGGDVF 162 >4KDC-A nrPDB Length = 246 Score = 43.3 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 32/116 (27%), Positives = 52/116 (44%), Gaps = 11/116 (9%) Query: 62 VFQNKHHFEGKTVLDVGTGSGILAIWSAQAGARKVYAVEATKMADHARALVKANNLDHIV 121 + + GK VLDVG G GILA A+ GA V M + K + L+ + Sbjct: 54 IAERAGGLFGKKVLDVGCGGGILAESMAREGA----TVTGLDMGFEPLQVAKLHALESGI 109 Query: 122 EV--IEGSVEDISLPE--KVDVIISEWMGYFLLRESMFDSVISARDRWLKPTGVMY 173 +V ++ +VE+ + + DV+ M L SV+ A + +KP G ++ Sbjct: 110 QVDYVQETVEEHAAKHAGQYDVVTCMEM---LEHVPDPQSVVRACAQLVKPGGDVF 162 >4KRG-A nrPDB Length = 466 Score = 42.5 bits (98), Expect = 3e-04, Method: Composition-based stats. Identities = 28/142 (19%), Positives = 58/142 (40%), Gaps = 8/142 (5%) Query: 35 YFCTYSFLYHQKDMLSDRVRMD---AYFNAVFQNKHHFEGKTVLDVGTGSGILAIWSAQA 91 ++ YS M+ ++ D + + + H K V+D+G G G A+ Sbjct: 19 FWDKYSDKPDTNSMMLNQTAQDLEASDRADILSSLPHLTNKDVVDIGAGIGRFTTVLAET 78 Query: 92 GARKVYAVEATKMADHARALVKANNLDHIVEVIEGSVEDISLPEK-VDVIISEWMGYFLL 150 AR V + + + + N + G + + EK VD++ + W+ +L Sbjct: 79 -ARWVLSTDF--IESFIEKNQERNAHMGNISYQIGDAVHLQMDEKSVDLVFTNWLMMYLS 135 Query: 151 RESMFDSVISARDRWLKPTGVM 172 + + +++A RWL+ G + Sbjct: 136 DREVIEFLLNAM-RWLRADGYI 156 >1XDU-A nrPDB Length = 374 Score = 42.5 bits (98), Expect = 3e-04, Method: Composition-based stats. Identities = 31/104 (29%), Positives = 46/104 (44%), Gaps = 9/104 (8%) Query: 74 VLDVGTGSG-ILAIWSAQAGARKVYAVEATKMADHARALVKANNLDHIVEVIEGSVEDIS 132 VLDVG G+G +LA + +A + VE A+ AR L V V EG Sbjct: 186 VLDVGGGNGGMLAAIALRAPHLRGTLVELAGPAERARRRFADAGLADRVTVAEGDFFK-P 244 Query: 133 LPEKVDVIISEWMGYFLLR---ESMFDSVISARDRWLKPTGVMY 173 LP DV++ + + LL E +++ R L+P G + Sbjct: 245 LPVTADVVL---LSFVLLNWSDEDAL-TILRGCVRALEPGGRLL 284 >4LG1-A nrPDB Length = 224 Score = 42.2 bits (97), Expect = 4e-04, Method: Composition-based stats. Identities = 19/98 (19%), Positives = 41/98 (41%), Gaps = 8/98 (8%) Query: 66 KHHFEGKTVLDVGTGSGILAIWSAQAGARKVYAVEATKMADHARALVKANNL----DHIV 121 H ++VL++G+G+G + + +A GA V + ++ D + + N Sbjct: 58 AHALSRRSVLELGSGTGAVGLMAATLGAD-VVVTDLEELQDLLKMNINMNKHLVTGSVQA 116 Query: 122 EVIEGSVEDISLPEKVDVIISEWMGYFLLRESMFDSVI 159 +V++ E P D I+ M + E + ++ Sbjct: 117 KVLKWGEEIEGFPSPPDFIL---MADCIYYEESLEPLL 151 >5WP5-A nrPDB Length = 491 Score = 42.2 bits (97), Expect = 4e-04, Method: Composition-based stats. Identities = 38/165 (23%), Positives = 68/165 (41%), Gaps = 19/165 (11%) Query: 26 VDKEVDYAQYFCTYSFLYHQKDML----SDRVRMDAYFNAVFQNKHHFEGKTVLDVGTGS 81 ++++ + + S L + ML SD + + V +EGK+VL++G G Sbjct: 7 EERDIQKSYWMEHSSDLTVEAMMLDSKASDLDKEE--RPEVLSLIPPYEGKSVLELGAGI 64 Query: 82 GILAIWSAQAGARKVYAVEATKMADHARALVKANNLDHIVEVIEGSVEDISLPEK---VD 138 G AQ A +V A++ + A V N ++ + V L K +D Sbjct: 65 GRFTGELAQ-KAGEVIALDFIESAIQKNESV--NGHYKNIKFMCADVTSPDLKIKDGSID 121 Query: 139 VIISEWMGYFLLR---ESMFDSVISARDRWLKPTGVMYPSHARMW 180 +I S W+ +L E M + +I W+KP G ++ + Sbjct: 122 LIFSNWLLMYLSDKEVELMAERMIG----WVKPGGYIFFRESCFH 162 Score = 35.2 bits (79), Expect = 0.054, Method: Composition-based stats. Identities = 32/130 (24%), Positives = 49/130 (37%), Gaps = 8/130 (6%) Query: 71 GKTVLDVGTGSGILAIWSAQAGARKVYAVEAT-KMADHARALVKANNLDHIVEVIEGSVE 129 G+ VLDVG G G + A+ V ++ + M A +A L VE Sbjct: 283 GQKVLDVGCGIGGGDFYMAENFDVHVVGIDLSVNMISFALE--RAIGLKCSVEFEVADCT 340 Query: 130 DISLPEKV-DVIISEWMGYFLLRESMFDSVISARDRWLKPTG-VMYPSHARMWLAPIKSN 187 + P+ DVI S +L ++ +WLKP G V+ + R P Sbjct: 341 TKTYPDNSFDVIYSR---DTILHIQDKPALFRTFFKWLKPGGKVLITDYCRSAETPSPEF 397 Query: 188 IADRKRNDFD 197 K+ +D Sbjct: 398 AEYIKQRGYD 407 >3A26-A nrPDB Length = 301 Score = 41.8 bits (96), Expect = 5e-04, Method: Composition-based stats. Identities = 28/166 (16%), Positives = 48/166 (28%), Gaps = 28/166 (16%) Query: 71 GKTVLDVGTGSGILAIWSAQAGARKVYAVEATKMA-DHARALVKANNLDHIVEVIEGSVE 129 + V+D+ G G L++ A G KV A+E + N ++ + Sbjct: 149 DELVVDMFAGIGHLSLPIAVYGKAKVIAIEKDPYTFKFLVENIHLNKVEDRMSAYNMDNR 208 Query: 130 DISLPEKVDVIISEWMGYFLLRESMFDSVISARDRWLKPTGVMYPSHARM--WLAPIKSN 187 D D I+ MGY + +S + G + H + L P + Sbjct: 209 DFPGENIADRIL---MGYVVRTHEFIPKALS-----IAKDGAIIHYHNTVPEKLMPREPF 260 Query: 188 IADRKRNDFDGAMADWHNFSDEIKSYYGVDMGVLTKPFAEEQEKYY 233 I YG D+ L + + Sbjct: 261 ET-----------------FKRITKEYGYDVEKLNELKIKRYAPGV 289 >5FAD-A nrPDB Length = 161 Score = 41.4 bits (95), Expect = 6e-04, Method: Composition-based stats. Identities = 20/114 (17%), Positives = 46/114 (40%), Gaps = 9/114 (7%) Query: 62 VFQNKHHFEGKTVLDVGTGSGILAIWSAQA-GARKVYAVEAT-KMADHARALVKANNLDH 119 + + + V D+G G G + I +A+ +K VE + A A ++ N + Sbjct: 20 MLEIAKVSQDDIVYDLGCGDGRIIITAAKDFNVKKAVGVEINDERIREALANIEKNGVTG 79 Query: 120 IVEVIEGSVEDISLPEKVDVIISEWMGYFLLRESMFDSVISARDRWLKPTGVMY 173 +++G+ ++ + E V L ++ + + ++ LKP + Sbjct: 80 RASIVKGNFFEVDISEATVV-------TMFLLTNVNEMLKPKLEKELKPGTRVV 126 >6GKZ-A nrPDB Length = 351 Score = 41.4 bits (95), Expect = 7e-04, Method: Composition-based stats. Identities = 22/108 (20%), Positives = 46/108 (42%), Gaps = 10/108 (9%) Query: 70 EGKTVLDVGTGSGILAIWSAQAGAR-KVYAV--EATKMADHARALVKANNLDHIVEVIEG 126 +G++VLD+G G G L + AQ +V AV ++ + N L+ V++ Sbjct: 123 DGQSVLDLGCGQGALTLHVAQKYKNCRVTAVTNSVSQKEYIEEESRRRNLLNVEVKL--A 180 Query: 127 SVEDISLPEKVD-VIISEWMGYFLLRESMFDSVISARDRWLKPTGVMY 173 + + E D +++ E + E + + W+ G+++ Sbjct: 181 DITTHEMAETYDRILVIELFEHMKNYELLLRKI----SEWISKDGLLF 224 >4PNE-A nrPDB Length = 302 Score = 40.6 bits (93), Expect = 0.001, Method: Composition-based stats. Identities = 33/157 (21%), Positives = 56/157 (35%), Gaps = 19/157 (12%) Query: 74 VLDVGTGSGILAIWSAQAGARKVYAVEATKMAD-HARALVKANNLDHIVEVIEGSVEDIS 132 +LDVG G+G A+ A+ A ++ + +++ A + L H V+ V+ +S Sbjct: 96 LLDVGCGTGQPALRVARDNAIQITGITVSQVQVAIAADCARERGLSHRVDF--SCVDAMS 153 Query: 133 LPEKVDVIISEWMGYFLLRESMFDSVISARDRWLKPTGVM-------------YPSHARM 179 LP + + W LL S D I R LKP G++ P Sbjct: 154 LPYPDNAFDAAWAMQSLLEMSEPDRAIREILRVLKPGGILGVTEVVKREAGGGMPVSGDR 213 Query: 180 WLAP---IKSNIADRKRNDFDGAMADWHNFSDEIKSY 213 W + + DW + S + + Sbjct: 214 WPTGLRICLAEQLLESLRAAGFEILDWEDVSSRTRYF 250 >5YAC-A nrPDB Length = 346 Score = 40.2 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 22/77 (28%), Positives = 38/77 (49%), Gaps = 5/77 (6%) Query: 66 KHHFEGKTVLDVGTGSGILAIWSAQAGARKVYAVEATKMA-DHARALVKANNLDHIVEVI 124 K EG+ V D+ G G +I A+ A V+A + A + +K N ++++V ++ Sbjct: 194 KMAQEGEVVFDMFAGVGPFSILLAK-KAELVFACDINPWAIKYLEENIKLNKVNNVVPIL 252 Query: 125 EGSVEDISLPEKVDVII 141 G +I + K D II Sbjct: 253 -GDSREIEV--KADRII 266 >3EGE-A nrPDB Length = 261 Score = 40.2 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 23/84 (27%), Positives = 39/84 (46%), Gaps = 8/84 (9%) Query: 60 NAVFQNKHHFEGKTVLDVGTGSGILAIWSAQAGARKVYAVEATKMADHARALVKANNLDH 119 NA+ + +G + D+G G+G ++ A G VYAVE + + + Sbjct: 24 NAIINLLNLPKGSVIADIGAGTGGYSVALANQGL-FVYAVEPSIVMRQQAVVHPQVEW-- 80 Query: 120 IVEVIEGSVEDISLPEK-VDVIIS 142 G E+++LP+K VD +IS Sbjct: 81 ----FTGYAENLALPDKSVDGVIS 100 >3CJR-A nrPDB Length = 254 Score = 39.8 bits (91), Expect = 0.002, Method: Composition-based stats. Identities = 29/110 (26%), Positives = 46/110 (41%), Gaps = 12/110 (10%) Query: 66 KHHFEGKTVLDVGTGSGILAIWSAQAGARKVYAVEATKM-ADHARALVKANNLDHIVEVI 124 +H G VLD+GTGSG+LAI + + G + + V+ M A A K N + Sbjct: 116 RHLRPGDKVLDLGTGSGVLAIAAEKLGGKAL-GVDIDPMVLPQAEANAKRNGVRPR---F 171 Query: 125 EGSVEDISLP-EKVDVIISEWMGYFLLRESMFDSVISARDRWLKPTGVMY 173 + +LP D++++ Y L ++ A L P G Sbjct: 172 LEGSLEAALPFGPFDLLVANL--YAELHAALAPRYREA----LVPGGRAL 215 >2PJD-A nrPDB Length = 343 Score = 39.5 bits (90), Expect = 0.002, Method: Composition-based stats. Identities = 25/121 (20%), Positives = 51/121 (42%), Gaps = 17/121 (14%) Query: 68 HFEGKTVLDVGTGSGILAIWSAQAGAR-KVYAVEAT-KMADHARALVKANNLDHIV---E 122 H +GK VLDVG G+G+L++ A+ + ++ + + + +RA + AN ++ V Sbjct: 195 HTKGK-VLDVGCGAGVLSVAFARHSPKIRLTLCDVSAPAVEASRATLAANGVEGEVFASN 253 Query: 123 VIEGSVEDISLPEKVDVIISEWMGYFLLRESMFDSVISARDRWLKPTGVMYPSHARMWLA 182 V + + D+IIS + M + + A ++ S + + Sbjct: 254 VFS------EVKGRFDMIISNP----PFHDGM-QTSLDAAQTLIRGAVRHLNSGGELRIV 302 Query: 183 P 183 Sbjct: 303 A 303 >4QNV-A nrPDB Length = 323 Score = 39.5 bits (90), Expect = 0.002, Method: Composition-based stats. Identities = 26/137 (18%), Positives = 50/137 (36%), Gaps = 3/137 (2%) Query: 38 TYSFLYHQKDMLSDRVRMDAYFNAVFQNKHHFEGKTVLDVGTGSGILAIWSAQAGARKVY 97 + R D ++ V + G+T+LDVG GSG AGA Sbjct: 90 RKGPFSLYGVNIDTEWRSDWKWDRVLPHLSDLTGRTILDVGCGSGYHMWRMIGAGAHLAV 149 Query: 98 AVEATKMADHARALVK-ANNLDHIVEVIEGSVEDISLPEKVDVIISEWMGYFLLRESMFD 156 ++ T++ V+ D ++ +E + + D + S MG R S + Sbjct: 150 GIDPTQLFLCQFEAVRKLLGNDQRAHLLPLGIEQLPALKAFDTVFS--MGVLYHRRSPLE 207 Query: 157 SVISARDRWLKPTGVMY 173 + +D+ + ++ Sbjct: 208 HLWQLKDQLVNEGELVL 224 >4QPN-A nrPDB Length = 227 Score = 39.5 bits (90), Expect = 0.003, Method: Composition-based stats. Identities = 24/110 (21%), Positives = 46/110 (41%), Gaps = 9/110 (8%) Query: 68 HFEGKTVLDVGTGSGILAIWSAQAGARKVYAVEATKMADHARALVKAN---NLDHIVEVI 124 F GK V+++G G+GI+ I +A G V + + + V+AN V + Sbjct: 74 DFRGKKVIELGAGTGIVGILAALQGGD-VTITDLPLALEQIQGNVQANVPAGGQAQVRAL 132 Query: 125 EGSVEDISLPEKVDVIISEWMGYFLLR-ESMFDSVISARDRWLKPTGVMY 173 ++ P D++ +G ++ E F ++ +P G +Y Sbjct: 133 SWGIDHHVFPANYDLV----LGADIVYLEPTFPLLLGTLQHLCRPHGTIY 178 >4FS8-A nrPDB Length = 383 Score = 39.1 bits (89), Expect = 0.003, Method: Composition-based stats. Identities = 40/198 (20%), Positives = 70/198 (35%), Gaps = 36/198 (18%) Query: 9 AMGGRAAGTGGGGPSAPVDKEVDYAQYFCTYSFLYH------------QKDMLSD---RV 53 A G + + GG PS Y + + + L + +L+D V Sbjct: 6 ASGCQKSKNGGSTPSIRDHVADYYGKTLQSSADLKTSACKLAAAVPESHRKILADIADEV 65 Query: 54 RMDAYF-NAVFQNKHHFEGKTVLDVGTGSGILAIWSAQAGAR--KVYAVEATKM-ADHAR 109 Y + EG TVLD+G G+G +++ KV V+ + AR Sbjct: 66 LEKFYGCGSTLPADGSLEGATVLDLGCGTGRDVYLASKLVGEHGKVIGVDMLDNQLEVAR 125 Query: 110 ALVKA-------NNLDHIVEVIEGSVEDISLPEK-------VDVIISEWMGYFLLRESMF 155 V+ + V ++G +E+++ E VD++IS + + Sbjct: 126 KYVEYHAEKFFGSPSRSNVRFLKGFIENLATAEPEGVPDSSVDIVISNCVCNLSTNKLAL 185 Query: 156 DSVISARDRWLKPTGVMY 173 I R L+ G +Y Sbjct: 186 FKEIH---RVLRDGGELY 200 >1DUS-A nrPDB Length = 194 Score = 38.7 bits (88), Expect = 0.004, Method: Composition-based stats. Identities = 23/115 (20%), Positives = 45/115 (39%), Gaps = 3/115 (2%) Query: 60 NAVFQNKHHFEGKTVLDVGTGSGILAIWSAQAGARKVYAVEATKMADHARALVKANNLDH 119 + +N + +LD+G G G++ I A A + A+ +K NNLD+ Sbjct: 42 KILVENVVVDKDDDILDLGCGYGVIGIALADEVKSTTMADINRRAIKLAKENIKLNNLDN 101 Query: 120 -IVEVIEGSVEDISLPEKVDVIISEWMGYFLLRESMFDSVISARDRWLKPTGVMY 173 + V+ + + K + II+ + + +I LK G ++ Sbjct: 102 YDIRVVHSDLYENVKDRKYNKIITNP--PIRAGKEVLHRIIEEGKELLKDNGEIW 154 >5BP9-A nrPDB Length = 281 Score = 38.3 bits (87), Expect = 0.006, Method: Composition-based stats. Identities = 30/164 (18%), Positives = 59/164 (35%), Gaps = 29/164 (17%) Query: 73 TVLDVGTGSGILAIWSAQAGARKVYAVEATKMADHARALVKANNLDH--IVEVIEGSVED 130 T+LDVG GSG A+ + Q ++V A++ + ++ ++K + V + + Sbjct: 104 TILDVGAGSGCHAL-ALQESGKEVSAIDISPLS---VEVMKLRGVKDARQVNLFDERFA- 158 Query: 131 ISLPEKVDVIISEWMGYFLLR--ESMFDSVISARDRWLKPTGVMYPSHARM--------- 179 D I+ G ++ E+M + L+P G + + + Sbjct: 159 ----ATFDTILMLMNGSGIIGRLENM-PLFFRKMKQLLRPDGCILMDSSDLRYLFEDEDG 213 Query: 180 -WLAPIKSNIADR-----KRNDFDGAMADWHNFSDEIKSYYGVD 217 +L + + + D G DW + S Y D Sbjct: 214 SFLIDLAGDYYGEIDFRMQYKDIQGDPFDWLYIDFQTLSAYAAD 257 >2YXD-A nrPDB Length = 183 Score = 37.9 bits (86), Expect = 0.007, Method: Composition-based stats. Identities = 19/65 (29%), Positives = 33/65 (50%), Gaps = 7/65 (10%) Query: 70 EGKTVLDVGTGSGILAIWSAQAGARKVYAVEATKMADHARALVKANNLDHIVE---VIEG 126 + V+DVG GSG + + A+ + VYA++ D A + K N ++ +I+G Sbjct: 35 KDDVVVDVGCGSGGMTVEIAK-RCKFVYAID---YLDGAIEVTKQNLAKFNIKNCQIIKG 90 Query: 127 SVEDI 131 ED+ Sbjct: 91 RAEDV 95 >4P7C-A nrPDB Length = 322 Score = 37.9 bits (86), Expect = 0.008, Method: Composition-based stats. Identities = 31/131 (23%), Positives = 51/131 (38%), Gaps = 8/131 (6%) Query: 68 HFEGKTVLDVGTGSGILAIWSAQAGARKVYAVEATKMADHARALVKANNLDHIVEVIEGS 127 +GK VLDVG G+G AGA V V+ + ++ D + + Sbjct: 119 DLKGKRVLDVGCGNGYYQWRMLGAGADSVIGVDPNWLFFCQFQAMQRYLPDLPAWHLPFA 178 Query: 128 VEDI-SLPEKVDVIISEWMGYFLLRESMFDSVISARDRWLKPT-----GVMYPSHARMWL 181 +ED+ + E D + S MG R+S D +++ +D +K ++ P L Sbjct: 179 LEDLPANLEGFDTVFS--MGVLYHRKSPIDHLLALKDCLVKGGELVMETLVIPGDVHQVL 236 Query: 182 APIKSNIADRK 192 P R Sbjct: 237 VPEDRYAQMRN 247 >5I2H-A nrPDB Length = 364 Score = 37.5 bits (85), Expect = 0.009, Method: Composition-based stats. Identities = 16/85 (18%), Positives = 34/85 (40%), Gaps = 1/85 (1%) Query: 62 VFQNKHHFEGKTVLDVGTGSGILAIWSAQAGARKV-YAVEATKMADHARALVKANNLDHI 120 + ++ G+ +LDV GSGI + Q + ++ A L + + Sbjct: 188 ILKDNSGSSGRVLLDVAGGSGIYTMAVLQKYPTWRGIIFDRPEVLKIAAELAEQTGVRDR 247 Query: 121 VEVIEGSVEDISLPEKVDVIISEWM 145 +E+ G + P D+++S + Sbjct: 248 LELHAGDMWVDPFPPADDILLSNVL 272 >3DMF-A nrPDB Length = 381 Score = 37.5 bits (85), Expect = 0.010, Method: Composition-based stats. Identities = 29/113 (25%), Positives = 50/113 (44%), Gaps = 9/113 (7%) Query: 66 KHHFEGKTVLDVGTGSGILAIWSAQAGARKVYAVEATKMADHARA-LVKANNLDHIVEVI 124 G+ VLD+G G G L + A+ GA V VE + + ++AN L + Sbjct: 229 PEGVRGRQVLDLGAGYGALTLPLARMGAE-VVGVEDDLASVLSLQKGLEANALKAQ--AL 285 Query: 125 EGSVEDISLPE-KVDVIISEW---MGYFLLRESMFDSVISARDRWLKPTGVMY 173 V++ E + D+I++ +G ++ + V A R L+P GV + Sbjct: 286 HSDVDEALTEEARFDIIVTNPPFHVGGAVILDVAQAFVNVAAAR-LRPGGVFF 337 >2XVM-A nrPDB Length = 199 Score = 37.5 bits (85), Expect = 0.011, Method: Composition-based stats. Identities = 23/126 (18%), Positives = 52/126 (41%), Gaps = 2/126 (1%) Query: 46 KDMLSDRVRMDAYFNAVFQNKHHFEGKTVLDVGTGSGILAIWSAQAGARKVYAVEATKMA 105 ++ +D+ + + V + + LD+G G+G +++ A G V A + M+ Sbjct: 8 ENYFTDKYELTRTHSEVLEAVKVVKPGKTLDLGCGNGRNSLYLAANGYD-VDAWDKNAMS 66 Query: 106 DHARALVKANNLDHIVEVIEGSVEDISLPEKVDVIISEWMGYFLLRESMFDSVISARDRW 165 +K+ + + +++ + D I+S + FL ++ +I+ R Sbjct: 67 IANVERIKSIENLDNLHTRVVDLNNLTFDRQYDFILSTVVLMFLEAKT-IPGLIANMQRC 125 Query: 166 LKPTGV 171 KP G Sbjct: 126 TKPGGY 131 >1VQ1-A nrPDB Length = 294 Score = 37.1 bits (84), Expect = 0.013, Method: Composition-based stats. Identities = 17/60 (28%), Positives = 30/60 (50%), Gaps = 1/60 (1%) Query: 72 KTVLDVGTGSGILAIWSAQAGARKVYAVEATKMA-DHARALVKANNLDHIVEVIEGSVED 130 KTV D+GTGSG + + A+ V+A + + A + AR + + + V +G + Sbjct: 135 KTVADIGTGSGAIGVSVAKFSDAIVFATDVSSKAVEIARKNAERHGVSDRFFVRKGEFLE 194 >3GRV-A nrPDB Length = 295 Score = 36.8 bits (83), Expect = 0.017, Method: Composition-based stats. Identities = 21/76 (27%), Positives = 36/76 (47%), Gaps = 3/76 (3%) Query: 58 YFNAVFQNKHHFEGKTVLDVGTGSGILAIWSAQAGARKVYAVEATKMADHARALVKANNL 117 + N ++ + + VL++G G GIL A+ A+KVY +E K + K L Sbjct: 38 FVNKAVESANLTKDDVVLEIGLGKGILTEELAK-NAKKVYVIEIDKSLEPYAN--KLKEL 94 Query: 118 DHIVEVIEGSVEDISL 133 + +E+I G + L Sbjct: 95 YNNIEIIWGDALKVDL 110 >3FYD-A nrPDB Length = 263 Score = 36.8 bits (83), Expect = 0.017, Method: Composition-based stats. Identities = 21/76 (27%), Positives = 36/76 (47%), Gaps = 3/76 (3%) Query: 58 YFNAVFQNKHHFEGKTVLDVGTGSGILAIWSAQAGARKVYAVEATKMADHARALVKANNL 117 + N ++ + + VL++G G GIL A+ A+KVY +E K + K L Sbjct: 9 FVNKAVESANLTKDDVVLEIGLGKGILTEELAK-NAKKVYVIEIDKSLEPYAN--KLKEL 65 Query: 118 DHIVEVIEGSVEDISL 133 + +E+I G + L Sbjct: 66 YNNIEIIWGDALKVDL 81 >3CCF-A nrPDB Length = 279 Score = 36.8 bits (83), Expect = 0.018, Method: Composition-based stats. Identities = 27/121 (22%), Positives = 47/121 (38%), Gaps = 11/121 (9%) Query: 58 YFNAVFQNKHHFEGKTVLDVGTGSGILAIWSAQAGARKVYAVEATKMADHARALVKANNL 117 Y + Q + G+ +LD+G G+G L AQ+GA + A M + AR + Sbjct: 45 YGEDLLQLLNPQPGEFILDLGCGTGQLTEKIAQSGAEVLGTDNAATMIEKARQNYPHLHF 104 Query: 118 DHIVEVIEGSVEDISLPEKVDVIISEWMGYFLLR-ESMFDSVISARDRWLKPTGVMYPSH 176 D + + + +D + S M +++ E+ S+ A LK G Sbjct: 105 D------VADARNFRVDKPLDAVFSNAMLHWVKEPEAAIASIHQA----LKSGGRFVAEF 154 Query: 177 A 177 Sbjct: 155 G 155 >1I9G-A nrPDB Length = 280 Score = 36.8 bits (83), Expect = 0.018, Method: Composition-based stats. Identities = 30/124 (24%), Positives = 48/124 (38%), Gaps = 14/124 (11%) Query: 62 VFQNKHHFEGKTVLDVGTGSGILAIWSAQA--GARKVYAVEA-TKMADHARALVK--ANN 116 + F G VL+ G GSG L + +A A +V + E A+HAR V Sbjct: 91 IVHEGDIFPGARVLEAGAGSGALTLSLLRAVGPAGQVISYEQRADHAEHARRNVSGCYGQ 150 Query: 117 LDHIVEVIEGSVEDISLPE-KVDVIISEWMGYFLLRESMFDSVISARDRWLKPTGVMYPS 175 ++ + D LP+ VD + + + + V+ A R L GV+ Sbjct: 151 PPDNWRLVVSDLADSELPDGSVDRAVLDMLAPW--------EVLDAVSRLLVAGGVLMVY 202 Query: 176 HARM 179 A + Sbjct: 203 VATV 206 >5WP4-A nrPDB Length = 491 Score = 36.8 bits (83), Expect = 0.018, Method: Composition-based stats. Identities = 32/130 (24%), Positives = 48/130 (36%), Gaps = 8/130 (6%) Query: 71 GKTVLDVGTGSGILAIWSAQAGARKVYAVEAT-KMADHARALVKANNLDHIVEVIEGSVE 129 G+ VLDVG G G + A+ V ++ + M A +A L VE Sbjct: 283 GQKVLDVGCGIGGGDFYMAEKFDVHVVGIDLSVNMISFALE--RAIGLSCSVEFEVADCT 340 Query: 130 DISLPEKV-DVIISEWMGYFLLRESMFDSVISARDRWLKPTG-VMYPSHARMWLAPIKSN 187 P+ DVI S +L ++ +WLKP G V+ + R P Sbjct: 341 TKHYPDNSFDVIYSR---DTILHIQDKPALFRTFFKWLKPGGKVLISDYCRSPKTPSAEF 397 Query: 188 IADRKRNDFD 197 K+ +D Sbjct: 398 SEYIKQRGYD 407 Score = 34.4 bits (77), Expect = 0.088, Method: Composition-based stats. Identities = 33/175 (18%), Positives = 67/175 (38%), Gaps = 33/175 (18%) Query: 23 SAPVDKEVDYAQYFCTYSFLYHQKDML----SDRVRMDAYFNAVFQNKHHFEGKTVLDVG 78 S ++++ + + L + ML SD + + V +EGK+VL++G Sbjct: 4 SYEEERDIQKNYWIEHSADLTVEAMMLDSRASDLDKEE--RPEVLSLLPPYEGKSVLELG 61 Query: 79 TGSGILAIWSAQAGARKVYAVEATKMADHARALVKANNLDHIVEVIEGSVEDISLPE--- 135 G G AQ A ++ A++ + K +++ + ++ D++ P+ Sbjct: 62 AGIGRFTGELAQ-KAGELIALDFIDNV-----IKKNESINGHYKNVKFMCADVTSPDLKI 115 Query: 136 ---KVDVIISEWM-------GYFLLRESMFDSVISARDRWLKPTGVMYPSHARMW 180 +D+I S W+ LL E M W+K G ++ + Sbjct: 116 TDGSLDLIFSNWLLMYLSDKEVELLAERMVG--------WIKVGGYIFFRESCFH 162 >1RI1-A nrPDB Length = 298 Score = 36.4 bits (82), Expect = 0.020, Method: Composition-based stats. Identities = 33/155 (21%), Positives = 61/155 (39%), Gaps = 8/155 (5%) Query: 70 EGKTVLDVGTGSGILAIWSAQAGARKVYAVEATKMADHARALVKANNLDHIVEVI----E 125 G +VLD+G G G + +AG + Y V+ +++ A V+A N+ +V + Sbjct: 64 RGDSVLDLGCGKGGDLLKYERAGIGEYYGVDIAEVS-INDARVRARNMKRRFKVFFRAQD 122 Query: 126 GSVEDISLPEKVDVIISEWMGYFLLRES-MFDSVISARDRWLKPTGVMYPSHARMWLAPI 184 + L ++ DVI S++ ++ S D R L+P G + + + Sbjct: 123 SYGRHMDLGKEFDVISSQFSFHYAFSTSESLDIAQRNIARHLRPGGYFIMTVPSRDVI-L 181 Query: 185 KSNIADRKRNDFDGAMAD-WHNFSDEIKSYYGVDM 218 + R NDF + + E Y + Sbjct: 182 ERYKQGRMSNDFYKIELEKMEDVPMESVREYRFTL 216 >4O29-A nrPDB Length = 208 Score = 36.0 bits (81), Expect = 0.026, Method: Composition-based stats. Identities = 29/106 (27%), Positives = 47/106 (44%), Gaps = 17/106 (16%) Query: 74 VLDVGTGSGILAIWSAQAGARK--VYAVE-ATKMADHARALVKANNLDHIVEVIEGSVE- 129 +L+VGTGSG A A+A +K +Y +E ++A A ++ +VEV G + Sbjct: 79 ILEVGTGSGYHAAVCAEAIEKKGRIYTIEIVKELAVFAAQNLERLGYWGVVEVYHGDGKK 138 Query: 130 --DISLPEKVDVIISEWMGYFLLRESMFDSVISARDRWLKPTGVMY 173 + P +I++ + D + A R LK GVM Sbjct: 139 GLEKHAPFDA-IIVT----------AAADVIPPALIRQLKDGGVMV 173 >3M70-A nrPDB Length = 286 Score = 35.6 bits (80), Expect = 0.037, Method: Composition-based stats. Identities = 36/202 (17%), Positives = 66/202 (32%), Gaps = 11/202 (5%) Query: 23 SAPVDKEVDYAQYFCTYSFLYHQKDMLSDRVRMDAYFNAVFQNKHHFEGKTVLDVGTGSG 82 V+ D + CT F ++D S + A V VLD+G G G Sbjct: 75 WHRVEALSDDLE--CTLGFYCKKEDYFSKKYNTTAIHGDVVDAAKIISPCKVLDLGCGQG 132 Query: 83 ILAIWSAQAGARKVYAVEATKMADHARALVKANNLDHIVEVIEGSVEDISLPEKVDVIIS 142 +++ + G V + + + + K +I + + ++ E D I+S Sbjct: 133 RNSLYLSLLGYD-VTSWDHNENSIAFLNETKEKENLNISTALY-DINAANIQENYDFIVS 190 Query: 143 EWMGYFLLRESMFDSVISARDRWLKPTGVMYPSHARMWLAPIK-SNIADRKRNDFDGAMA 201 + FL RE + + + ++ + + P N+ Sbjct: 191 TVVFMFLNRERVPSIIKNMKEHTNVGGYNLIVAAMSTDDVPCPLPFSFTFAENELKEYYK 250 Query: 202 DWHNFSDEIKSYYGVDMGVLTK 223 DW Y +MG L K Sbjct: 251 DWE------FLEYNENMGELHK 266 >6M83-A nrPDB Length = 263 Score = 35.6 bits (80), Expect = 0.039, Method: Composition-based stats. Identities = 25/114 (21%), Positives = 45/114 (39%), Gaps = 8/114 (7%) Query: 23 SAPVDKEVDYAQYFCTYSFLYHQKDMLSDRVRMDAYFNAVFQNKHHFEGKTVLDVGTGSG 82 SA + DY+ L + D R A A+ + +H + ++LDV G+G Sbjct: 5 SATAGPQADYSGEIAELYDL-VHQGKGKDYHREAADLAALVR-RHSPKAASLLDVACGTG 62 Query: 83 ILAIWSAQAGARKVYAVEATKMADHARALVKANNLDHIVEVIEGSVEDISLPEK 136 + A VE +++ A+ + N D ++ G + D SL + Sbjct: 63 ----MHLRHLADSFGTVEGLELSADMLAIARRRNPDAVLH--HGDMRDFSLGRR 110 >2AVN-A nrPDB Length = 260 Score = 35.2 bits (79), Expect = 0.053, Method: Composition-based stats. Identities = 28/148 (18%), Positives = 57/148 (38%), Gaps = 12/148 (8%) Query: 36 FCTYSFLYHQKDMLSDRVRMDAYFNAV--FQNKHHFEGKTVLDVGTGSGILAIWSAQAGA 93 + Y + D + + + Y + F ++ VLD+G G+G +++ + G Sbjct: 18 WEFYDRIARAYDSMYETPKWKLYHRLIGSFLEEYLKNPCRVLDLGGGTGKWSLFLQERGF 77 Query: 94 RKVYAVEATKMADHARALVKANNLDHIVEVIEGSVEDISLPEKV-DVIISEWMGYFLLRE 152 V + +M + AR + V+E ED+ P + +++ +G L Sbjct: 78 EVVLVDPSKEMLEVARE-------KGVKNVVEAKAEDLPFPSGAFEAVLA--LGDVLSYV 128 Query: 153 SMFDSVISARDRWLKPTGVMYPSHARMW 180 D S R L P G++ + + Sbjct: 129 ENKDKAFSEIRRVLVPDGLLIATVDNFY 156 >5U19-A nrPDB Length = 341 Score = 34.8 bits (78), Expect = 0.057, Method: Composition-based stats. Identities = 28/144 (19%), Positives = 50/144 (34%), Gaps = 19/144 (13%) Query: 75 LDVGTGSGILAIWSAQAGARKVYAVEATKMAD-HARALVKANNL-------DHIVEVIEG 126 LD+G GSG+L++ A V V+ A +R N L + E EG Sbjct: 148 LDMGCGSGVLSLVLAD-RYESVLGVDVNPRAVALSRLNAALNGLTNVTFREGDMFEPAEG 206 Query: 127 SVEDISLPEKVDVIISEWMGYFLLRESMFDSVISARDRWLKPTGVMYPSHARMWLAPIKS 186 I + +E++ E + ++ R L+ G + + Sbjct: 207 RFSRIVFNSPTNEEGNEFVDLLEAGEPILETFFRNVPRKLESGG----------IVEVNL 256 Query: 187 NIADRKRNDFDGAMADWHNFSDEI 210 + D + F +ADW ++ Sbjct: 257 AMNDYPGDPFRERLADWLGLTENG 280 >5GM1-A nrPDB Length = 297 Score = 34.8 bits (78), Expect = 0.068, Method: Composition-based stats. Identities = 13/48 (27%), Positives = 24/48 (50%) Query: 56 DAYFNAVFQNKHHFEGKTVLDVGTGSGILAIWSAQAGARKVYAVEATK 103 D Y + + + G+ +LD+G G+G A+ +A+ V V +K Sbjct: 63 DRYTDYLIETLDPKAGQHLLDIGCGTGRTALKAARQRGIAVTGVAVSK 110 >2I6G-A nrPDB Length = 199 Score = 34.4 bits (77), Expect = 0.082, Method: Composition-based stats. Identities = 25/142 (17%), Positives = 48/142 (33%), Gaps = 16/142 (11%) Query: 30 VDYAQYFCTYSFLYHQKDMLSDRVRMDAYFNAVFQNKHHFEGKTVLDVGTGSGILAIWSA 89 D + Y D+L+ LD+G G+G +++ A Sbjct: 5 RDENYFTEKYGLTRTHSDVLA--------------AAKVVAPGRTLDLGCGNGRNSLYLA 50 Query: 90 QAGARKVYAVEATKMADHARALVKANNLDHIVEVIEGSVEDISLPEKVDVIISEWMGYFL 149 G V A + + +KA ++ + ++ + D I+S + FL Sbjct: 51 ANGYD-VTAWDKNPASMANLERIKAAEGLDNLQTDLVDLNTLTFDGEYDFILSTVVMMFL 109 Query: 150 LRESMFDSVISARDRWLKPTGV 171 ++ +I+ R KP G Sbjct: 110 EAQT-IPGLIANMQRCTKPGGY 130 >5W7M-A nrPDB Length = 312 Score = 34.4 bits (77), Expect = 0.083, Method: Composition-based stats. Identities = 22/156 (14%), Positives = 60/156 (38%), Gaps = 19/156 (12%) Query: 48 MLSDRVRMDAYFNAVFQ----NKHHFEGKTVLDVGTGSGILA-------IWSAQAGARKV 96 M+++++ Y + Q ++ +LD+ G+G+++ + + Sbjct: 45 MVAEKI-TRYYTQDLIQLSGLSESSLTPLVILDLACGTGVVSDALHDMLNFQPKGNWELT 103 Query: 97 YAVEATKMADHARALVKANNLDHIV-EVIEGSVEDISLPEKVDVIISEWMGYFLLRESMF 155 +T++ H + + ++ + +V++ ++ V + F + Sbjct: 104 CGDISTELTGHVKQKILERGWENSIAKVVDAQNTELPTGHYTHVFAALAFTSFPDTYAAM 163 Query: 156 DSVISARDRWLKPTGVMYPSHA--RMWLAPIKSNIA 189 V+ R L+P G + S WLA +++ +A Sbjct: 164 KEVM----RILQPGGTLTISTWQRTEWLAVVEAAVA 195 >4HTF-A nrPDB Length = 285 Score = 34.4 bits (77), Expect = 0.088, Method: Composition-based stats. Identities = 28/105 (26%), Positives = 47/105 (44%), Gaps = 13/105 (12%) Query: 74 VLDVGTGSGILAIWSAQAGARKVYAVEATKMADHARALVKANNLDHIVEVIEGSVEDI-- 131 VLD G G G AI A+ G + + + +M D A+ +A + ++ I + +D+ Sbjct: 72 VLDAGGGEGQTAIKMAERGHQVILCDLSAQMIDRAKQAAEAKGVSDNMQFIHCAAQDVAS 131 Query: 132 SLPEKVDVI----ISEWMGYFLLRESMFDSVISARDRWLKPTGVM 172 L VD+I + EW+ SV+ L+P GV+ Sbjct: 132 HLETPVDLILFHAVLEWVAD-------PRSVLQTLWSVLRPGGVL 169 >5H02-A nrPDB Length = 283 Score = 34.4 bits (77), Expect = 0.091, Method: Composition-based stats. Identities = 29/149 (19%), Positives = 54/149 (36%), Gaps = 5/149 (3%) Query: 28 KEVDYAQYFCTYSFLYHQKDMLSDRVRMDAYFNAVFQNKHHFEGKTVLDVGTGSGILAIW 87 +E D F+ +++ R ++ + + K VLDV TG+G ++ Sbjct: 37 RESDGYTNEYVSGFVDKWDELIDWESRAESEGDTIINILKERGVKKVLDVATGTGFNSVR 96 Query: 88 SAQAGARKVYAVEATKMADHARALVKANNLDHIVEVIEGSVEDISLPEKVDVIISEWMG- 146 QAG V A + +M A + + + + + +K D I+ +G Sbjct: 97 LLQAGFDVVSADGSAEMLVKAFDNARDHGYLMRTVQADWRWMNKDIHDKFDAIVC--LGN 154 Query: 147 --YFLLRESMFDSVISARDRWLKPTGVMY 173 L E ++ LK GV+ Sbjct: 155 SFTHLFDEGDRRKALAEFYALLKHDGVLL 183 >1ZQ9-A nrPDB Length = 285 Score = 33.7 bits (75), Expect = 0.13, Method: Composition-based stats. Identities = 18/76 (23%), Positives = 30/76 (39%), Gaps = 2/76 (2%) Query: 60 NAVFQNKHHFEGKTVLDVGTGSGILAIWSAQAGARKVYAVEATKMADHARAL-VKANNLD 118 N++ VL+VG G+G + + A+KV A E V+ + Sbjct: 18 NSIIDKAALRPTDVVLEVGPGTGNMTV-KLLEKAKKVVACELDPRLVAELHKRVQGTPVA 76 Query: 119 HIVEVIEGSVEDISLP 134 ++V+ G V LP Sbjct: 77 SKLQVLVGDVLKTDLP 92 >5BXY-A nrPDB Length = 158 Score = 33.7 bits (75), Expect = 0.13, Method: Composition-based stats. Identities = 19/76 (25%), Positives = 35/76 (46%), Gaps = 3/76 (3%) Query: 62 VFQNKHHFEGKTVLDVGTGSGILAIWSAQ-AGARKVYAVEATK-MADHARALVKANNLDH 119 + + E + D+G+G G + I +A+ GAR V +E + AR K + Sbjct: 16 MLELADVDETDVLYDLGSGDGRIVIRAARTHGARGV-GIEIDPDLVKKARKNAKEAGVAD 74 Query: 120 IVEVIEGSVEDISLPE 135 +VE +G + + + E Sbjct: 75 LVEFRQGDLFEADISE 90 >2B25-A nrPDB Length = 336 Score = 33.7 bits (75), Expect = 0.13, Method: Composition-based stats. Identities = 44/221 (19%), Positives = 84/221 (38%), Gaps = 27/221 (12%) Query: 60 NAVFQNKHHFEGKTVLDVGTGSGILAIWSAQA-GAR-KVYAVEATK-MADHARALVKANN 116 N + G TVL+ G+GSG ++++ ++A G++ +V + E K D A+ K + Sbjct: 95 NMILSMMDINPGDTVLEAGSGSGGMSLFLSKAVGSQGRVISFEVRKDHHDLAKKNYK--H 152 Query: 117 LDHIVEVIEGSVEDISLPEKVDVIISEWMGYFLLRES---------MFDSVISARDRW-- 165 ++ VE+ P+ VD I + G +S M + ++ + Sbjct: 153 WRDSWKL--SHVEEW--PDNVDFIHKDISGATEDIKSLTFDAVALDMLNPHVTLPVFYPH 208 Query: 166 LKPTGVMYPSHARMWLAPIKSNIADRKRNDFDGAMADWHNFSDEIKSYYGVDMGVLTKPF 225 LK GV +++ I I S+ I + V + Sbjct: 209 LKHGGV-----CAVYVVNITQVIELLDGIRTCELALSCEKISEVIVRDWLVCLAKQKNGI 263 Query: 226 AEEQEKYYIQTAMWNDLNPQQIIGTPTIVKEMDCLTASVSE 266 ++ + I T + L+ Q+ IG + + D S S+ Sbjct: 264 LAQKVESKINTDV--QLDSQEKIGVKGELFQEDDHEESHSD 302 >6DCC-A nrPDB Length = 309 Score = 33.3 bits (74), Expect = 0.16, Method: Composition-based stats. Identities = 23/124 (18%), Positives = 47/124 (37%), Gaps = 22/124 (17%) Query: 16 GTGGGGPSAPVDKEVDYAQYFCTYSFLYHQKDMLSD-RVRMDAYFNAVFQNKHHFEGKTV 74 G P+A K+ QY + ++ D R+R+ F G+ V Sbjct: 16 PRGSPLPAAGFKKQQRKFQYGNYCKYYGYRNPSCEDGRLRVLK--------PEWFRGRDV 67 Query: 75 LDVGTGSGILAI-WSAQAGARKVYAVEA-TKMADHARALVKANNLDHIVEVIEGSVEDIS 132 LD+G G L + + + G ++ ++ +++ AR ++ E++ Sbjct: 68 LDLGCNVGHLTLSIACKWGPSRMVGLDIDSRLIHSARQNIR-----------HYLSEELR 116 Query: 133 LPEK 136 LP + Sbjct: 117 LPPQ 120 >1KP9-A nrPDB Length = 287 Score = 33.3 bits (74), Expect = 0.19, Method: Composition-based stats. Identities = 28/104 (26%), Positives = 42/104 (40%), Gaps = 4/104 (3%) Query: 71 GKTVLDVGTGSGILAIWSAQAGARKVYAVEATKM-ADHARALVKANNLDHIVEVIEGSVE 129 G T+LDVG G G + + + V + +K A+H + LV + V+ E Sbjct: 65 GMTLLDVGCGWGATMMRAVEKYDVNVVGLTLSKNQANHVQQLVANSENLRSKRVLLAGWE 124 Query: 130 DISLPEKVDVIISEWMGYFLLRESMFDSVISARDRWLKPTGVMY 173 E VD I+S + +D+ S R L GVM Sbjct: 125 QFD--EPVDRIVS-IGAFEHFGHERYDAFFSLAHRLLPADGVML 165 >6C5B-A nrPDB Length = 341 Score = 32.9 bits (73), Expect = 0.22, Method: Composition-based stats. Identities = 25/127 (19%), Positives = 45/127 (35%), Gaps = 13/127 (10%) Query: 29 EVDYAQYFCT--YSFLYHQKDMLSDRVRMDAYFNAVFQNKHHFEG-------KTVLDVGT 79 E + + F T + +L + +DRV +A Q H KTV+D+G Sbjct: 126 ETAFEKEFGTSYFGYLAKHPE--ADRVFNEAQAGYTKQVAHAVVDAYDFSPFKTVIDIGA 183 Query: 80 GSGILAIWSAQAGAR-KVYAVEATKMADHARALVKANNLDHIVEVIEGSVEDISLPEKVD 138 G G L ++ + + +A A + + + G + +P D Sbjct: 184 GYGPLLSAILRSQPEARGILFDQPHVAQAAGKRLAEAGVGDRCGTVGGDFF-VEVPADGD 242 Query: 139 VIISEWM 145 V I + Sbjct: 243 VYILSLL 249 >3NJR-A nrPDB Length = 204 Score = 32.9 bits (73), Expect = 0.24, Method: Composition-based stats. Identities = 19/114 (16%), Positives = 42/114 (36%), Gaps = 15/114 (13%) Query: 70 EGKTVLDVGTGSGILAIWSAQAGARKVYAVEATKMADHARALVKANNLDHIVEVIEGS-- 127 G+ + D+G GSG +++ AG R + ++ + + L + ++G+ Sbjct: 55 RGELLWDIGGGSGSVSVEWCLAGGRAITIEPRADRIENIQKNIDTYGLSPRMRAVQGTAP 114 Query: 128 --VEDISLPEKVDVIISEWMGYFLLRESMFDSVISARDRWLKPTGVMYPSHARM 179 + D+ LPE V + ++ WL P + + + Sbjct: 115 AALADLPLPEAV-----------FIGGGGSQALYDRLWEWLAPGTRIVANAVTL 157 >2YVL-A nrPDB Length = 248 Score = 32.9 bits (73), Expect = 0.24, Method: Composition-based stats. Identities = 24/68 (35%), Positives = 34/68 (50%), Gaps = 4/68 (5%) Query: 70 EGKTVLDVGTGSG-ILAIWSAQAGARKVY-AVEATKMADHARALVKANNLDHIVEVIEGS 127 + K VL+ GTGSG +LA+ S AG + AVE A+ +K NL V+ Sbjct: 91 KEKRVLEFGTGSGALLAVLSEVAGEVWTFEAVEEF--YKTAQKNLKKFNLGKNVKFFNVD 148 Query: 128 VEDISLPE 135 +D +PE Sbjct: 149 FKDAEVPE 156 >5EHG-A nrPDB Length = 276 Score = 32.9 bits (73), Expect = 0.26, Method: Composition-based stats. Identities = 28/99 (28%), Positives = 42/99 (42%), Gaps = 7/99 (7%) Query: 74 VLDVGTGSGILAIWSAQAGARKVYAVEA-TKMADHARALVKANNLD-HIVEVIEGSVEDI 131 V+D+G G G + + AG +KV V TK V + +IV+++ G Sbjct: 77 VIDLGCGRGGWSYYC--AGLKKVTEVRGYTKGGPGHEEPVPMSTYGWNIVKLMSGKDVFY 134 Query: 132 SLPEKVDVI---ISEWMGYFLLRESMFDSVISARDRWLK 167 PEK D + I E + ES V+ + WLK Sbjct: 135 LPPEKCDTLLCDIGESSPSPTVEESRTIRVLKMVEPWLK 173 >4V0R-A nrPDB Length = 892 Score = 32.9 bits (73), Expect = 0.26, Method: Composition-based stats. Identities = 28/99 (28%), Positives = 42/99 (42%), Gaps = 7/99 (7%) Query: 74 VLDVGTGSGILAIWSAQAGARKVYAVEA-TKMADHARALVKANNLD-HIVEVIEGSVEDI 131 V+D+G G G + + AG +KV V TK V + +IV+++ G Sbjct: 74 VIDLGCGRGGWSYYC--AGLKKVTEVRGYTKGGPGHEEPVPMSTYGWNIVKLMSGKDVFY 131 Query: 132 SLPEKVDVI---ISEWMGYFLLRESMFDSVISARDRWLK 167 PEK D + I E + ES V+ + WLK Sbjct: 132 LPPEKCDTLLCDIGESSPSPTVEESRTIRVLKMVEPWLK 170 >6BQC-A nrPDB Length = 383 Score = 32.5 bits (72), Expect = 0.28, Method: Composition-based stats. Identities = 28/100 (28%), Positives = 43/100 (43%), Gaps = 6/100 (6%) Query: 74 VLDVGTGSGILAIWSAQAGARKVYAVEATKMADHARALVKANNLDHIVEVIEGSVEDISL 133 VLD+G G G LA + A V V + A + LD V ++ D L Sbjct: 172 VLDIGCGWGGLAHYMASNYDVSVVGVTISA-EQQKMAQERCEGLD--VTILLQDYRD--L 226 Query: 134 PEKVDVIISEWMGYFLLRESMFDSVISARDRWLKPTGVMY 173 ++ D I+S M + + +D+ + DR LKP G+ Sbjct: 227 NDQFDRIVSVGM-FEHVGPKNYDTYFAVVDRNLKPEGIFL 265 >4DCM-A nrPDB Length = 375 Score = 32.5 bits (72), Expect = 0.32, Method: Composition-based stats. Identities = 15/59 (25%), Positives = 28/59 (47%), Gaps = 3/59 (5%) Query: 59 FNAVFQNKHHFEGKTVLDVGTGSGILAIWSAQAGAR-KVYAVEATKMADH-ARALVKAN 115 + + EG+ V D+G G+G++ + + KV V+ + MA +R V+ N Sbjct: 212 RFFMQHLPENLEGEIV-DLGCGNGVIGLTLLDKNPQAKVVFVDESPMAVASSRLNVETN 269 >3DOO-A nrPDB Length = 277 Score = 32.5 bits (72), Expect = 0.32, Method: Composition-based stats. Identities = 19/84 (22%), Positives = 34/84 (40%), Gaps = 7/84 (8%) Query: 58 YFNAVFQNKHHFEGKTVLDVGTGSGILAIWSAQAGARKVYAVEATKMADHARALVKANNL 117 Y N + Q E +L +G G +++ A ++Y + + R + + NN Sbjct: 104 YVNGLKQIYEGIEDAYILILGAGG------ASKGIANELYKIVRPTLTVANRTMSRFNNW 157 Query: 118 DHIVEVIEGSVEDISLPEKVDVII 141 + I S + L E D+II Sbjct: 158 SLNINKINLSHAESHLDE-FDIII 180 >5IKM-A nrPDB Length = 269 Score = 32.5 bits (72), Expect = 0.33, Method: Composition-based stats. Identities = 28/118 (23%), Positives = 45/118 (38%), Gaps = 8/118 (6%) Query: 55 MDAYFNAVFQNKHHFEGKTVLDVGTGSGILAIWSAQAGARKVYAVEATKMA--DHARALV 112 V +N EGK + D+G G G + + AG +KV V+ H + Sbjct: 62 TAKLRWFVERNLVKPEGKVI-DLGCGRGGWSYYC--AGLKKVTEVKGYTKGGPGHEEPIP 118 Query: 113 KANNLDHIVEVIEGSVEDISLPEKVDVI---ISEWMGYFLLRESMFDSVISARDRWLK 167 A ++V++ G PEK D + I E + E V+ + WL+ Sbjct: 119 MATYGWNLVKLHSGKDVFFIPPEKCDTLLCDIGESSPNPTIEEGRTLRVLKMVEPWLR 176 >3BKX-A nrPDB Length = 275 Score = 32.5 bits (72), Expect = 0.33, Method: Composition-based stats. Identities = 12/52 (23%), Positives = 25/52 (48%), Gaps = 2/52 (3%) Query: 54 RMDAYFNAVFQNKHHFEGKTVLDVGTGSGILA-IWSAQAGAR-KVYAVEATK 103 R A+ A+ + G+ +L++G G G L+ + + Q G+ V ++ Sbjct: 27 RQTAHRLAIAEAWQVKPGEKILEIGCGQGDLSAVLADQVGSSGHVTGIDIAS 78 >2VS1-A nrPDB Length = 425 Score = 32.1 bits (71), Expect = 0.37, Method: Composition-based stats. Identities = 22/82 (26%), Positives = 39/82 (47%), Gaps = 4/82 (4%) Query: 54 RMDAYF--NAVFQNKHHFEGKTVLDVGTGSGILAIWSAQAGARKVYAVEATKMA-DHARA 110 + ++Y N V + EG+ +LD+ +G G I+ A+ G V ++ + A + AR Sbjct: 272 QTNSYQAVNLVRKVSELVEGEKILDMYSGVGTFGIYLAKRGFN-VKGFDSNEFAIEMARR 330 Query: 111 LVKANNLDHIVEVIEGSVEDIS 132 V+ NN+D EV + Sbjct: 331 NVEINNVDAEFEVASDREVSVK 352 >3C3P-A nrPDB Length = 210 Score = 32.1 bits (71), Expect = 0.43, Method: Composition-based stats. Identities = 22/108 (20%), Positives = 48/108 (44%), Gaps = 10/108 (9%) Query: 70 EGKTVLDVGTGSGILAIWSAQAGA--RKVYAVEAT-KMADHARALVKANNLDHIVEVIEG 126 + + V+ G G G + W A+A + +V ++ +HAR ++ N L VE+ G Sbjct: 56 QPQLVVVPGDGLGCASWWFARAISISSRVVMIDPDRDNVEHARRMLHDNGLIDRVELQVG 115 Query: 127 SVEDISLPEK-VDVIISEWMGYFLLRESMFDSVISARDRWLKPTGVMY 173 I+ ++ +D++ +M + + V+ +R L ++ Sbjct: 116 DPLGIAAGQRDIDIL---FMDCDVFNGA---DVLERMNRCLAKNALLI 157 >3OPN-A nrPDB Length = 232 Score = 32.1 bits (71), Expect = 0.44, Method: Composition-based stats. Identities = 14/45 (31%), Positives = 22/45 (48%) Query: 60 NAVFQNKHHFEGKTVLDVGTGSGILAIWSAQAGARKVYAVEATKM 104 A+ + GKT LD+G+ +G Q GA+ VYA++ Sbjct: 27 KALKEFHLEINGKTCLDIGSSTGGFTDVMLQNGAKLVYALDVGTN 71 >3HP7-A nrPDB Length = 291 Score = 31.8 bits (70), Expect = 0.58, Method: Composition-based stats. Identities = 23/109 (21%), Positives = 37/109 (33%), Gaps = 12/109 (11%) Query: 68 HFEGKTVLDVGTGSGILAIWSAQAGARKVYAVEATKMADHARALVKANNLDHIVEVIEGS 127 E +D+G +G Q GA+ VYAV+ LV D V Sbjct: 83 SVEDMITIDIGASTGGFTDVMLQNGAKLVYAVDVGTN-----QLVWKLRQDDRVR--SME 135 Query: 128 VEDISLPEKVDVIISEWMGYFLLRES---MFDSVISARDRWLKPTGVMY 173 + E VD +E + F + + ++ A + L G + Sbjct: 136 QYNFRYAEPVD--FTEGLPSFASIDVSFISLNLILPALAKILVDGGQVV 182 >5MGZ-A nrPDB Length = 236 Score = 31.8 bits (70), Expect = 0.59, Method: Composition-based stats. Identities = 33/193 (17%), Positives = 66/193 (34%), Gaps = 18/193 (9%) Query: 70 EGKTVLDVGTGSGIL-AIWSAQAGARKVYAVEATK-MADHARALVKANN----LDHIVEV 123 +G+TV+D+ GSG L I S++ + + V+ ++ M AR H Sbjct: 39 DGQTVVDLCCGSGELEVILSSRFPSLNLVGVDLSEDMVRIAREYAAEQGKALEFRHGDAQ 98 Query: 124 IEGSVEDISLPEKVDVIISEWMGYFLLRESMFDSVISARDRWLKPTGVMYPSHARMWLAP 183 + +ED L K D+++S R + + R KP G + ++ P Sbjct: 99 LLAGMED--LAGKADLVVSR---NAFHRLTRLPAAFDTMLRLAKPGGAVL---NCSFIHP 150 Query: 184 IKSNIADRKRNDFDGAMADWH---NFSDEIKSYYGVDMGVLTKPFAE-EQEKYYIQTAMW 239 + + + W + +Y + + A+ +E + +W Sbjct: 151 SDFDESGFRAWVTFLNQRPWDSEMQIVWALAHHYAPRLDDYREALAQAARETPVSEQRVW 210 Query: 240 NDLNPQQIIGTPT 252 D + Sbjct: 211 IDDQGYGVPTVKC 223 >3QPM-A nrPDB Length = 240 Score = 31.4 bits (69), Expect = 0.62, Method: Composition-based stats. Identities = 11/89 (12%), Positives = 26/89 (29%), Gaps = 6/89 (6%) Query: 169 TGVMYPSHARMWLAPIKSNIADRKRNDFDGAMADWHNFSDEIKSYYGVDMGVLTKPFAEE 228 G +YP A + P+ + + W + + + + + Sbjct: 25 GGHVYPGEA--FRVPVSDHSLHLSKAKISKPAPQWEGTAVINGEFKELKLSDYRGKY--- 79 Query: 229 QEKYYIQTAMWNDLNPQQIIGTPTIVKEM 257 ++ + + P +II V E Sbjct: 80 -LVFFFYPLDFTFVCPTEIIAFSDRVHEF 107 >3P9N-A nrPDB Length = 189 Score = 31.4 bits (69), Expect = 0.72, Method: Composition-based stats. Identities = 20/63 (31%), Positives = 27/63 (42%), Gaps = 4/63 (6%) Query: 51 DRVRMDAYFNAVFQNKHHFEGKTVLDVGTGSGILAIWSAQAGARKVYAVE--ATKMADHA 108 DRVR + + + G VLD+ GSG L + + GA V VE A A Sbjct: 27 DRVRESLFN--IVTARRDLTGLAVLDLYAGSGALGLEALSRGAASVLFVESDQRSAAVIA 84 Query: 109 RAL 111 R + Sbjct: 85 RNI 87 >4QDJ-A nrPDB Length = 238 Score = 31.4 bits (69), Expect = 0.77, Method: Composition-based stats. Identities = 19/76 (25%), Positives = 32/76 (42%), Gaps = 5/76 (6%) Query: 68 HFEGKTVLDVGTGSGILAIWSAQAGARKVYAVEATK--MADHARALVKANNLDHIVEVIE 125 + G V D G G G L+I AQAGA VY + ++ + + + + + + Sbjct: 60 NLPGLLVCDAGCGVGSLSIPLAQAGA-LVYGSDISEKMVGEAQQKAQEVLAYGNQPTFMT 118 Query: 126 GSVEDISLPEKVDVII 141 + L K D +I Sbjct: 119 QDLAQ--LGGKYDTVI 132 >1R74-A nrPDB Length = 294 Score = 31.0 bits (68), Expect = 0.85, Method: Composition-based stats. Identities = 17/60 (28%), Positives = 27/60 (45%), Gaps = 2/60 (3%) Query: 52 RVRMDAYFNAVFQNKHHFEGKTVLDVGTGSGILAIWSAQAGARKVYAVEAT-KMADHARA 110 R R Y + + VLDV G+G+ +I + G V +V+A+ KM +A Sbjct: 38 RSRTAEYKAWLLGLLRQHGCQRVLDVACGTGVDSIMLVEEGFS-VTSVDASDKMLKYALK 96 >6H1E-A nrPDB Length = 208 Score = 31.0 bits (68), Expect = 0.96, Method: Composition-based stats. Identities = 20/75 (26%), Positives = 39/75 (52%), Gaps = 6/75 (8%) Query: 72 KTVLDVGTGSGILAIW-SAQAGARKVY-AVEATK-MADHARALVKANNLDHIVEVIEGSV 128 + L+VG+GSG+++ + ++ G + +Y + A + N + HI VI V Sbjct: 41 EICLEVGSGSGVVSAFLASMIGPQALYMCTDINPEAAACTLETARCNKV-HIQPVITDLV 99 Query: 129 EDI--SLPEKVDVII 141 + + L EKVD+++ Sbjct: 100 KGLLPRLTEKVDLLV 114 >2OXT-A nrPDB Length = 265 Score = 31.0 bits (68), Expect = 1.0, Method: Composition-based stats. Identities = 16/70 (22%), Positives = 31/70 (44%), Gaps = 4/70 (5%) Query: 74 VLDVGTGSGILAIWSAQAGARKVYAVEATKMADHARALVK-ANNLDHIVEVIEGSVEDIS 132 V+D+G G G + ++ A V V A + + + + + + V+ + Sbjct: 78 VVDLGCGRGGWSYYA--ASRPHVMDVRAYTLGVGGHEVPRITESYGWNIVKFKSRVDIHT 135 Query: 133 LP-EKVDVII 141 LP E+ DVI+ Sbjct: 136 LPVERTDVIM 145 >4LEC-A nrPDB Length = 212 Score = 30.6 bits (67), Expect = 1.2, Method: Composition-based stats. Identities = 12/47 (25%), Positives = 26/47 (55%), Gaps = 1/47 (2%) Query: 69 FEGKTVLDVGTGSGILAIWSAQAGARKVYAVEATKMADHARALVKAN 115 G++ +++G G+G++ I +A GA V + + ++ V+AN Sbjct: 58 LRGRSAVELGAGTGLVGIVAALLGA-HVTITDRKVALEFLKSNVQAN 103 >4MTL-A nrPDB Length = 244 Score = 30.6 bits (67), Expect = 1.3, Method: Composition-based stats. Identities = 15/71 (21%), Positives = 36/71 (50%), Gaps = 3/71 (4%) Query: 68 HFEGKTVLDVGTGSGILAIWSAQAGARKVYAVEATKMADHARALVKANNLDHIVEVIEGS 127 +F+ +L++G G G+++I ++ GA+ V A + + + + + N L + Sbjct: 90 NFQDAKILEIGAGPGLVSIVASILGAQ-VTATDLPDVLGNLQYNLLKNTLQCTAHL--PE 146 Query: 128 VEDISLPEKVD 138 V+++ E +D Sbjct: 147 VKELVWGEDLD 157 >1D2C-A nrPDB Length = 292 Score = 30.2 bits (66), Expect = 1.7, Method: Composition-based stats. Identities = 14/38 (36%), Positives = 22/38 (57%), Gaps = 2/38 (5%) Query: 74 VLDVGTGSGILAIWSAQAGARKVYAVEAT-KMADHARA 110 VLDV G+G+ +I + G V +V+A+ KM +A Sbjct: 60 VLDVACGTGVDSIMLVEEGFS-VTSVDASDKMLKYALK 96 >3R9X-B nrPDB Length = 248 Score = 29.4 bits (64), Expect = 2.5, Method: Composition-based stats. Identities = 18/70 (25%), Positives = 31/70 (44%), Gaps = 4/70 (5%) Query: 62 VFQNKHHFEGKTVLDVGTGSGILAIWSAQAGARKVYAVEATKMADHARALVKANNLDHIV 121 + + + EG TV++VG G+G L Q +K+Y +E + +K+ D + Sbjct: 22 IAEELNIEEGNTVVEVGGGTGNLTKVLLQHPLKKLYVIE---LDREMVENLKSIG-DERL 77 Query: 122 EVIEGSVEDI 131 EVI Sbjct: 78 EVINEDASKF 87 >6ERQ-F nrPDB Length = 377 Score = 29.4 bits (64), Expect = 2.9, Method: Composition-based stats. Identities = 32/118 (27%), Positives = 48/118 (40%), Gaps = 5/118 (4%) Query: 62 VFQNKHHFEGKTVLDVGTGSGILAIWSAQAGARKVYAVEATKMADHARALVKANNLDHIV 121 ++ K +L+ G GIL +AGA KV A+E+ K + N LD + Sbjct: 68 IYLGKPSRPPHLLLECNPGPGILTQALLEAGA-KVVALESDKTFIPHLESLGKN-LDGKL 125 Query: 122 EVIEGSVEDISLPEKVDVIISEWMGYFLLRESM-FDSVISARDRWLKPTGVMYPSHAR 178 VI + P VI M L +++ ++V D LK G M+PS Sbjct: 126 RVIHCDFFKLD-PRSGGVIKPPAMSSRGLFKNLGIEAVPWTADIPLKVVG-MFPSRGE 181 >6ERO-A nrPDB Length = 313 Score = 29.4 bits (64), Expect = 2.9, Method: Composition-based stats. Identities = 32/118 (27%), Positives = 48/118 (40%), Gaps = 5/118 (4%) Query: 62 VFQNKHHFEGKTVLDVGTGSGILAIWSAQAGARKVYAVEATKMADHARALVKANNLDHIV 121 ++ K +L+ G GIL +AGA KV A+E+ K + N LD + Sbjct: 27 IYLGKPSRPPHLLLECNPGPGILTQALLEAGA-KVVALESDKTFIPHLESLGKN-LDGKL 84 Query: 122 EVIEGSVEDISLPEKVDVIISEWMGYFLLRESM-FDSVISARDRWLKPTGVMYPSHAR 178 VI + P VI M L +++ ++V D LK G M+PS Sbjct: 85 RVIHCDFFKLD-PRSGGVIKPPAMSSRGLFKNLGIEAVPWTADIPLKVVG-MFPSRGE 140 >1GKM-A nrPDB Length = 509 Score = 28.3 bits (61), Expect = 5.2, Method: Composition-based stats. Identities = 15/88 (17%), Positives = 27/88 (30%) Query: 166 LKPTGVMYPSHARMWLAPIKSNIADRKRNDFDGAMADWHNFSDEIKSYYGVDMGVLTKPF 225 LKP + + AP++ + D ++A E ++ YG++ G Sbjct: 5 LKPGTLTLAQLRAIHAAPVRLQLDASAAPAIDASVACVEQIIAEDRTAYGINTGFGLLAS 64 Query: 226 AEEQEKYYIQTAMWNDLNPQQIIGTPTI 253 L+ IG P Sbjct: 65 TRIASHDLENLQRSLVLSHAAGIGAPLD 92 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.307 0.118 0.293 Lambda K H 0.267 0.0366 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 12,839,275 Number of Sequences: 36641 Number of extensions: 482312 Number of successful extensions: 1901 Number of sequences better than 10.0: 108 Number of HSP's better than 10.0 without gapping: 78 Number of HSP's successfully gapped in prelim test: 90 Number of HSP's that attempted gapping in prelim test: 1670 Number of HSP's gapped (non-prelim): 175 length of query: 383 length of database: 10,336,785 effective HSP length: 99 effective length of query: 284 effective length of database: 6,709,326 effective search space: 1905448584 effective search space used: 1905448584 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.2 bits) S2: 60 (27.9 bits)