BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q9LDI3 (446 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 4D28-A nrPDB 902 0.0 4CZT-A nrPDB 556 e-159 2EHB-D nrPDB 293 8e-80 3H4J-B nrPDB 275 3e-74 5EZV-A nrPDB 265 3e-71 4CFF-A nrPDB 265 3e-71 2YZA-A nrPDB 261 3e-70 4REW-A nrPDB 261 3e-70 3MN3-A nrPDB 261 4e-70 4CFH-A nrPDB 261 6e-70 4RED-A nrPDB 260 7e-70 4CQG-A nrPDB 234 5e-62 5ES1-A nrPDB 234 7e-62 5KZ7-A nrPDB 231 5e-61 4D2V-A nrPDB 231 7e-61 4YNZ-A nrPDB 230 8e-61 2QNJ-A nrPDB 230 8e-61 2HAK-A nrPDB 223 9e-59 6C9D-A nrPDB 221 5e-58 5WAX-A nrPDB 213 1e-55 5YKS-A nrPDB 213 2e-55 3UC3-A nrPDB 198 4e-51 3ZUT-A nrPDB 198 5e-51 3UDB-A nrPDB 197 1e-50 5IG1-A nrPDB 196 2e-50 4B8L-A nrPDB 191 4e-49 2JC6-A nrPDB 189 2e-48 3BHH-A nrPDB 185 3e-47 2VN9-A nrPDB 185 4e-47 4FG9-A nrPDB 185 4e-47 3D2K-A nrPDB 184 8e-47 5FG8-A nrPDB 184 1e-46 3F3Z-A nrPDB 182 2e-46 5U6Y-A nrPDB 181 5e-46 4UZD-A nrPDB 181 7e-46 2VZ6-A nrPDB 181 7e-46 2JAM-A nrPDB 181 8e-46 1FOT-A nrPDB 179 2e-45 2BDW-A nrPDB 179 2e-45 2BRG-A nrPDB 179 3e-45 3KK8-A nrPDB 178 4e-45 3SOA-A nrPDB 177 9e-45 2W4O-A nrPDB 177 9e-45 4JXF-A nrPDB 173 2e-43 2V7O-A nrPDB 171 5e-43 2YCR-A nrPDB 171 5e-43 6CMJ-A nrPDB 170 1e-42 3NCG-A nrPDB 169 2e-42 3I6U-A nrPDB 169 3e-42 3KN6-A nrPDB 169 3e-42 4B6L-A nrPDB 169 3e-42 5JZN-A nrPDB 167 6e-42 3DFA-A nrPDB 167 9e-42 4I6B-A nrPDB 167 1e-41 5JN2-A nrPDB 166 2e-41 3TXO-A nrPDB 165 3e-41 3MA6-A nrPDB 164 5e-41 2Y7J-A nrPDB 164 6e-41 5YV8-A nrPDB 164 8e-41 5N23-A nrPDB 164 1e-40 4AF3-A nrPDB 162 2e-40 2YAB-A nrPDB 162 2e-40 3LIJ-A nrPDB 162 2e-40 4WB7-A nrPDB 162 3e-40 3HZT-A nrPDB 162 3e-40 2Z7Q-A nrPDB 162 3e-40 5XZW-A nrPDB 162 3e-40 5X3F-B nrPDB 162 3e-40 4RGJ-A nrPDB 161 5e-40 3DXN-A nrPDB 161 5e-40 4PDS-A nrPDB 160 1e-39 2A27-A nrPDB 159 2e-39 4MVF-A nrPDB 159 3e-39 5D9K-A nrPDB 157 7e-39 2J90-A nrPDB 157 8e-39 4L42-A nrPDB 155 3e-38 2JDO-A nrPDB 155 3e-38 4RLP-A nrPDB 155 3e-38 4YZB-A nrPDB 155 4e-38 3Q5I-A nrPDB 154 6e-38 3DB8-A nrPDB 154 6e-38 1ZWS-A nrPDB 154 7e-38 3GUB-A nrPDB 154 9e-38 5KCV-A nrPDB 151 5e-37 3MV5-A nrPDB 151 7e-37 6FDY-U nrPDB 150 1e-36 5DYK-A nrPDB 150 1e-36 5F9E-A nrPDB 149 2e-36 6BDL-A nrPDB 149 2e-36 6CCF-A nrPDB 148 4e-36 4J52-A nrPDB 148 4e-36 4NIF-A nrPDB 148 5e-36 3TAC-A nrPDB 147 7e-36 5FET-A nrPDB 147 7e-36 2OU7-A nrPDB 147 7e-36 4JG6-A nrPDB 147 1e-35 2WTK-C nrPDB 146 2e-35 3ORZ-A nrPDB 145 3e-35 1VZO-A nrPDB 145 4e-35 3HDN-A nrPDB 143 2e-34 1PHK-A nrPDB 143 2e-34 3A8W-A nrPDB 141 5e-34 6E9W-A nrPDB 141 6e-34 4C0T-A nrPDB 141 6e-34 4WNO-A nrPDB 140 8e-34 4APC-A nrPDB 139 2e-33 6QAU-A nrPDB 139 3e-33 5LOH-A nrPDB 138 6e-33 4RA4-A nrPDB 137 9e-33 1KOA-A nrPDB 136 2e-32 6ED6-A nrPDB 135 3e-32 3UTO-A nrPDB 135 3e-32 6BXI-A nrPDB 134 6e-32 4FR4-A nrPDB 133 2e-31 2I0E-A nrPDB 133 2e-31 3PFQ-A nrPDB 132 3e-31 1NY3-A nrPDB 131 5e-31 3IS5-A nrPDB 131 5e-31 2OZA-A nrPDB 131 6e-31 4X7Q-B nrPDB 130 1e-30 3DLS-A nrPDB 129 2e-30 2X4F-A nrPDB 129 3e-30 3KA0-A nrPDB 129 3e-30 1KOB-A nrPDB 125 3e-29 2XNP-A nrPDB 123 1e-28 4KS7-A nrPDB 123 1e-28 4BBM-A nrPDB 123 2e-28 2WQN-A nrPDB 122 3e-28 3FXW-A nrPDB 122 4e-28 5UUU-A nrPDB 120 1e-27 3PVW-A nrPDB 120 2e-27 3HKO-A nrPDB 119 4e-27 2F57-A nrPDB 119 4e-27 6GU6-A nrPDB 118 6e-27 2BPM-A nrPDB 118 6e-27 4RC3-A nrPDB 117 1e-26 3BGP-A nrPDB 117 1e-26 3TKU-A nrPDB 115 3e-26 6DC0-A nrPDB 115 3e-26 5TUR-A nrPDB 115 3e-26 5CEK-A nrPDB 115 4e-26 4KRC-A nrPDB 114 6e-26 4AW2-A nrPDB 114 7e-26 4CRS-A nrPDB 114 7e-26 2Q0N-A nrPDB 112 4e-25 4OTD-A nrPDB 112 4e-25 4JDH-A nrPDB 112 5e-25 4XBR-A nrPDB 112 5e-25 6FD3-A nrPDB 111 5e-25 2HW6-A nrPDB 111 7e-25 4FIE-A nrPDB 111 8e-25 1TKI-A nrPDB 110 8e-25 3PPZ-A nrPDB 110 1e-24 3DAK-A nrPDB 110 2e-24 4AU8-A nrPDB 110 2e-24 3NIZ-A nrPDB 109 2e-24 4TNB-A nrPDB 108 3e-24 2UV2-A nrPDB 108 4e-24 4EQM-A nrPDB 108 4e-24 1V0B-A nrPDB 108 4e-24 6HXF-B nrPDB 108 5e-24 3Q53-A nrPDB 108 6e-24 4LQP-A nrPDB 108 6e-24 3ZDU-A nrPDB 108 6e-24 3LM0-A nrPDB 108 7e-24 3COM-A nrPDB 107 1e-23 5J5T-A nrPDB 107 1e-23 3ORP-A nrPDB 107 1e-23 3M42-A nrPDB 105 3e-23 6CKI-A nrPDB 105 5e-23 2VD5-A nrPDB 105 5e-23 4AGU-A nrPDB 105 5e-23 5DBX-A nrPDB 103 1e-22 1ZXE-A nrPDB 103 2e-22 6AO5-A nrPDB 102 5e-22 4LG4-A nrPDB 101 7e-22 5EFQ-A nrPDB 100 1e-21 1UA2-A nrPDB 100 2e-21 4BGQ-A nrPDB 100 2e-21 4QMW-A nrPDB 100 2e-21 6E2O-A nrPDB 99 3e-21 6CQF-A nrPDB 99 3e-21 5L2Q-C nrPDB 98 8e-21 4NST-A nrPDB 98 8e-21 2XIK-A nrPDB 98 9e-21 3C51-A nrPDB 98 9e-21 1U5R-A nrPDB 97 1e-20 2GCD-A nrPDB 97 1e-20 6DTL-A nrPDB 97 2e-20 4OW8-A nrPDB 96 3e-20 4ZSG-A nrPDB 96 4e-20 4U41-A nrPDB 96 4e-20 6B2Q-A nrPDB 96 4e-20 4X3F-A nrPDB 96 5e-20 3E7O-A nrPDB 95 7e-20 4IC8-A nrPDB 94 8e-20 3QA8-A nrPDB 94 1e-19 3NYO-A nrPDB 94 2e-19 2F9G-A nrPDB 93 2e-19 5TQX-A nrPDB 93 2e-19 5H2U-A nrPDB 93 3e-19 5D7A-A nrPDB 92 4e-19 4FZF-B nrPDB 91 1e-18 4E7W-A nrPDB 91 1e-18 4CSV-A nrPDB 91 1e-18 4KIK-B nrPDB 90 2e-18 5G6V-A nrPDB 90 2e-18 5AIR-A nrPDB 89 3e-18 4M7I-A nrPDB 89 3e-18 5O0Y-A nrPDB 89 4e-18 4C59-A nrPDB 89 4e-18 5AWM-A nrPDB 89 4e-18 4YHJ-A nrPDB 89 5e-18 3MIA-A nrPDB 88 6e-18 2XS0-A nrPDB 88 7e-18 6CTH-A nrPDB 87 1e-17 4UYA-A nrPDB 87 1e-17 4HVI-A nrPDB 87 1e-17 5Z33-A nrPDB 87 2e-17 4GS6-A nrPDB 86 2e-17 4UY9-A nrPDB 86 2e-17 5VD3-A nrPDB 86 3e-17 5HI2-A nrPDB 86 4e-17 3FI2-A nrPDB 86 5e-17 3HMP-A nrPDB 86 5e-17 6NPU-A nrPDB 85 6e-17 5AP3-A nrPDB 85 8e-17 4EWQ-A nrPDB 85 8e-17 5IKW-A nrPDB 85 8e-17 1JNK-A nrPDB 85 8e-17 2PMN-X nrPDB 84 8e-17 2W1I-A nrPDB 84 9e-17 4XEY-B nrPDB 84 9e-17 4EBW-A nrPDB 84 1e-16 5NGU-A nrPDB 84 1e-16 3IO7-A nrPDB 84 1e-16 3GC9-A nrPDB 84 1e-16 3DTC-A nrPDB 84 1e-16 6GVJ-A nrPDB 84 2e-16 4PWN-A nrPDB 84 2e-16 4JLC-A nrPDB 84 2e-16 5HVK-A nrPDB 83 2e-16 2ZMD-A nrPDB 83 2e-16 1G3N-A nrPDB 83 2e-16 5O2B-A nrPDB 83 2e-16 4F0G-A nrPDB 83 2e-16 4QTB-A nrPDB 83 2e-16 4E93-A nrPDB 83 3e-16 4TPT-A nrPDB 83 3e-16 4YFF-A nrPDB 82 3e-16 4AN9-A nrPDB 82 3e-16 4EUT-A nrPDB 82 4e-16 2XYN-A nrPDB 82 4e-16 6NT9-A nrPDB 82 4e-16 6DBM-A nrPDB 82 4e-16 5O2C-A nrPDB 82 5e-16 2FO0-A nrPDB 82 5e-16 3OZ6-A nrPDB 82 5e-16 4EUU-A nrPDB 82 5e-16 3GC0-A nrPDB 82 7e-16 5HIE-A nrPDB 82 7e-16 5KKR-C nrPDB 81 7e-16 3EQC-A nrPDB 81 8e-16 2J0K-A nrPDB 81 8e-16 4HZS-A nrPDB 81 9e-16 1U54-B nrPDB 81 9e-16 6O8B-A nrPDB 81 9e-16 3DKO-A nrPDB 81 9e-16 1S9I-A nrPDB 81 9e-16 3OHT-A nrPDB 81 1e-15 3KUL-B nrPDB 81 1e-15 5VO2-A nrPDB 80 1e-15 1CM8-A nrPDB 80 1e-15 4QNY-A nrPDB 80 2e-15 4Y83-A nrPDB 80 2e-15 5X5O-A nrPDB 80 2e-15 3E3P-A nrPDB 80 2e-15 5TE0-A nrPDB 80 2e-15 4Y93-A nrPDB 80 2e-15 3SXS-A nrPDB 79 3e-15 6DBN-A nrPDB 79 3e-15 4MYG-A nrPDB 79 4e-15 3A4O-X nrPDB 79 4e-15 2H34-A nrPDB 78 6e-15 4P5Q-A nrPDB 78 7e-15 2Y4I-B nrPDB 78 7e-15 4XI2-A nrPDB 78 9e-15 6E4F-A nrPDB 78 9e-15 6O6Q-A nrPDB 78 9e-15 5UIU-A nrPDB 77 1e-14 2W96-B nrPDB 77 1e-14 2R2P-A nrPDB 77 1e-14 4NEU-A nrPDB 77 1e-14 4OLI-A nrPDB 77 1e-14 1BYG-A nrPDB 77 1e-14 4O2Z-A nrPDB 77 2e-14 1K9A-A nrPDB 77 2e-14 2H8H-A nrPDB 77 2e-14 3EB0-A nrPDB 77 2e-14 6F3F-A nrPDB 77 2e-14 3QGY-A nrPDB 76 3e-14 3OMV-A nrPDB 76 3e-14 4IDT-A nrPDB 75 4e-14 5SYS-A nrPDB 75 4e-14 4G3E-A nrPDB 75 5e-14 4E20-A nrPDB 75 5e-14 4PDO-A nrPDB 75 6e-14 2I6L-A nrPDB 75 7e-14 3VN9-A nrPDB 75 7e-14 3FME-A nrPDB 75 7e-14 2Y6O-A nrPDB 74 1e-13 5ZTN-A nrPDB 74 2e-13 2HK5-A nrPDB 73 2e-13 5X8I-B nrPDB 73 2e-13 3ALO-A nrPDB 73 3e-13 3QUP-A nrPDB 73 3e-13 3NIE-A nrPDB 73 3e-13 4PL5-B nrPDB 72 5e-13 3QD2-B nrPDB 71 1e-12 5LPZ-A nrPDB 70 2e-12 3N9X-A nrPDB 70 2e-12 1U59-A nrPDB 70 2e-12 2VWV-A nrPDB 70 2e-12 5LPV-A nrPDB 70 2e-12 3RP9-A nrPDB 70 2e-12 4LFI-A nrPDB 70 2e-12 2WTK-B nrPDB 70 3e-12 2PL0-A nrPDB 69 3e-12 2DQ7-X nrPDB 69 3e-12 5B2L-A nrPDB 69 3e-12 4XCU-A nrPDB 69 5e-12 4H1J-A nrPDB 69 5e-12 2BUJ-A nrPDB 69 5e-12 2A1A-B nrPDB 68 8e-12 1AD5-A nrPDB 68 8e-12 5XVU-A nrPDB 68 1e-11 4CRL-A nrPDB 68 1e-11 5TOS-A nrPDB 67 1e-11 6HV0-A nrPDB 67 1e-11 3UIU-A nrPDB 67 1e-11 2OZO-A nrPDB 67 2e-11 2QKW-B nrPDB 67 2e-11 5Y86-A nrPDB 66 3e-11 5U6B-A nrPDB 66 3e-11 5L6P-A nrPDB 65 4e-11 6FYV-A nrPDB 65 4e-11 2RIO-A nrPDB 65 5e-11 2PSQ-A nrPDB 65 5e-11 3PLS-A nrPDB 65 5e-11 5AMN-A nrPDB 65 5e-11 5U6C-A nrPDB 65 7e-11 1JPA-A nrPDB 65 7e-11 5WNO-A nrPDB 65 7e-11 3UIM-A nrPDB 65 8e-11 1FVR-A nrPDB 64 1e-10 2JD5-A nrPDB 64 1e-10 3BEA-A nrPDB 64 1e-10 2PVN-A nrPDB 64 1e-10 4F9B-A nrPDB 64 1e-10 6GQK-A nrPDB 64 2e-10 3GQL-A nrPDB 64 2e-10 3TT0-A nrPDB 64 2e-10 2WO6-A nrPDB 64 2e-10 4K33-A nrPDB 63 2e-10 2OGV-A nrPDB 63 3e-10 5X02-A nrPDB 63 3e-10 5EG3-A nrPDB 63 3e-10 3PG1-A nrPDB 63 3e-10 5MJB-A nrPDB 63 3e-10 4XUF-A nrPDB 63 3e-10 5A46-A nrPDB 62 3e-10 4M66-A nrPDB 62 4e-10 2PZI-A nrPDB 62 6e-10 3Q4U-A nrPDB 61 8e-10 5UNP-A nrPDB 61 1e-09 6EII-A nrPDB 61 1e-09 5FM2-A nrPDB 61 1e-09 4Y12-A nrPDB 61 1e-09 4R7H-A nrPDB 61 1e-09 3LMG-A nrPDB 60 2e-09 4XLV-A nrPDB 60 2e-09 6HMD-A nrPDB 60 2e-09 3BBT-B nrPDB 60 2e-09 4MD7-E nrPDB 60 2e-09 3MY0-A nrPDB 60 3e-09 6J5U-C nrPDB 60 3e-09 5M07-A nrPDB 60 3e-09 3V5Q-A nrPDB 59 3e-09 3KRL-A nrPDB 59 5e-09 5AR8-A nrPDB 59 6e-09 3ZZW-A nrPDB 57 1e-08 4AT3-A nrPDB 57 2e-08 5WNL-A nrPDB 56 3e-08 3I81-A nrPDB 56 3e-08 4JRN-A nrPDB 56 3e-08 4L00-A nrPDB 56 4e-08 4IAN-A nrPDB 56 4e-08 5XD6-A nrPDB 55 7e-08 3PP0-A nrPDB 54 1e-07 5GRN-A nrPDB 54 1e-07 5C26-A nrPDB 54 2e-07 5HLW-A nrPDB 54 2e-07 1PY5-A nrPDB 54 2e-07 3C1X-A nrPDB 53 2e-07 1LUF-A nrPDB 53 2e-07 3G0E-A nrPDB 53 2e-07 5GNK-A nrPDB 53 3e-07 3RAW-A nrPDB 53 3e-07 5OAT-A nrPDB 53 3e-07 4FL3-A nrPDB 53 3e-07 3LZB-A nrPDB 53 3e-07 3MDY-A nrPDB 52 5e-07 6J6I-B nrPDB 52 6e-07 3SV0-A nrPDB 50 1e-06 6FEX-A nrPDB 50 2e-06 3AOX-A nrPDB 50 2e-06 3REP-A nrPDB 50 2e-06 5X18-A nrPDB 49 3e-06 3LLT-A nrPDB 49 4e-06 5E8V-A nrPDB 49 4e-06 2ZFD-B nrPDB 49 5e-06 3CJF-A nrPDB 49 6e-06 3ZBF-A nrPDB 49 6e-06 6BFN-A nrPDB 48 7e-06 6FER-A nrPDB 48 1e-05 6BSD-A nrPDB 48 1e-05 4NFN-A nrPDB 47 1e-05 4BTK-A nrPDB 47 1e-05 4TN6-A nrPDB 47 2e-05 5FQD-C nrPDB 47 2e-05 5KMM-A nrPDB 47 2e-05 2QLU-A nrPDB 47 2e-05 4M69-B nrPDB 46 3e-05 4WUA-A nrPDB 46 3e-05 4BTF-A nrPDB 46 3e-05 5X1R-A nrPDB 46 3e-05 4LRM-A nrPDB 46 3e-05 5CLR-A nrPDB 46 4e-05 4XHL-A nrPDB 45 5e-05 4XHH-A nrPDB 45 6e-05 3SOC-A nrPDB 45 7e-05 3G2F-A nrPDB 44 1e-04 3HNG-A nrPDB 44 2e-04 2CHL-A nrPDB 43 2e-04 5USZ-A nrPDB 43 2e-04 4NT4-A nrPDB 43 3e-04 2CMW-A nrPDB 43 3e-04 2C47-A nrPDB 42 6e-04 4OAU-C nrPDB 42 6e-04 4O1O-A nrPDB 42 6e-04 2X7G-A nrPDB 41 8e-04 5VC6-A nrPDB 41 0.001 4RT7-A nrPDB 40 0.002 4MWI-A nrPDB 39 0.003 1CSN-A nrPDB 39 0.004 3VHK-A nrPDB 39 0.006 6EQI-C nrPDB 38 0.008 4IX6-A nrPDB 38 0.008 5VDK-A nrPDB 38 0.009 5C01-A nrPDB 38 0.010 4WOV-A nrPDB 37 0.013 4AZW-A nrPDB 37 0.026 5J0A-A nrPDB 36 0.029 5UI3-D nrPDB 35 0.045 3Q60-A nrPDB 35 0.049 4K0V-A nrPDB 35 0.049 2GY7-B nrPDB 35 0.051 4AZV-A nrPDB 35 0.052 2W1Z-A nrPDB 33 0.21 3DZO-A nrPDB 33 0.23 3BYV-A nrPDB 33 0.32 4CI6-B nrPDB 33 0.37 2JMM-A nrPDB 31 1.0 1SGF-G nrPDB 29 3.2 6BHC-A nrPDB 29 3.5 1TQY-A nrPDB 29 4.5 2Y4N-A nrPDB 29 4.6 5UV4-A nrPDB 29 4.6 4A8J-B nrPDB 29 4.9 5VE6-A nrPDB 29 5.3 4EJS-B nrPDB 29 5.3 1Y0Y-A nrPDB 28 6.7 6EWX-A nrPDB 28 7.2 6G4J-A nrPDB 28 8.1 6H45-A nrPDB 28 9.8 >4D28-A nrPDB Length = 446 Score = 902 bits (2332), Expect = 0.0, Method: Compositional matrix adjust. Identities = 438/446 (98%), Positives = 439/446 (98%) Query: 1 MTKKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREI 60 MTKKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREI Sbjct: 1 MTKKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREI 60 Query: 61 SIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVD 120 SIMKIVRHPNIVRLYEVLAS SKIYIVLEFVTGGELFDRIVHKGRL+E ESRKYFQQLVD Sbjct: 61 SIMKIVRHPNIVRLYEVLASKSKIYIVLEFVTGGELFDRIVHKGRLKEDESRKYFQQLVD 120 Query: 121 AVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEV 180 AVAHCH KGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELL TCGTPNYVAPEV Sbjct: 121 AVAHCHSKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLNDTCGTPNYVAPEV 180 Query: 181 LSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFL 240 LSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEF CPPWFSAEVKFL Sbjct: 181 LSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFDCPPWFSAEVKFL 240 Query: 241 IHRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEVNLDDIRAVFDGIEGSYVAENV 300 IHRILDPNPKTRIQIQGIKKDPWFR NYVPIRAREEEEVNLDDIRAVFDGIEGSYVAENV Sbjct: 241 IHRILDPNPKTRIQIQGIKKDPWFRKNYVPIRAREEEEVNLDDIRAVFDGIEGSYVAENV 300 Query: 301 ERNDEGPLMMNAFEMITLSQGLNLSALFDRRQDFVKRQTRFVSRREPSEIIANIEAVANS 360 ERNDEGPLMMNAFEMITLSQGLNLSALFDRRQDFVKRQTRFVSRREPSEIIANIEAVANS Sbjct: 301 ERNDEGPLMMNAFEMITLSQGLNLSALFDRRQDFVKRQTRFVSRREPSEIIANIEAVANS 360 Query: 361 MGFKSHTRNFKTRLEGLSSIKAGQLAVVIEIYEVAPSLFMVDVRKAAGETLEYHKFYKKL 420 MGFKSHTRNFKTRLEGLSSIKAGQLAVVIEIYEVAPSLFMVDVRKAAGETLEYHKFYKKL Sbjct: 361 MGFKSHTRNFKTRLEGLSSIKAGQLAVVIEIYEVAPSLFMVDVRKAAGETLEYHKFYKKL 420 Query: 421 CSKLENIIWRATEGIPKSEILRTITF 446 CSKLENIIWRATEGIPKSEILRTITF Sbjct: 421 CSKLENIIWRATEGIPKSEILRTITF 446 >4CZT-A nrPDB Length = 464 Score = 556 bits (1432), Expect = e-159, Method: Compositional matrix adjust. Identities = 260/432 (60%), Positives = 336/432 (77%), Gaps = 7/432 (1%) Query: 7 RVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIV 66 RVGKYE+GRT+GEGTFAKVKFARN + GDNVAIK++ K +LKN+M+ QIKREIS MK++ Sbjct: 9 RVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLI 68 Query: 67 RHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCH 126 +HPN++R++EV+AS +KIY VLEFVTGGELFD+I GRL+E E+RKYFQQL++AV +CH Sbjct: 69 KHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCH 128 Query: 127 CKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVE--LLRTTCGTPNYVAPEVLSGQ 184 +GVYHRDLKPENLLLD NG LKVSDFGLSALPQ+ E LL TTCGTPNYVAPEV++ + Sbjct: 129 SRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNK 188 Query: 185 GYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRI 244 GYDG+ AD+WSCGVILFV++AGYLPF +++L LY+KI AEF+CPPWFSA K LI RI Sbjct: 189 GYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIKRI 248 Query: 245 LDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEVNLDDIRAVFDGIEGSYVAENVERND 304 LDPNP TRI + ++ WF+ Y + E +V+LDD+ A+FD G VER + Sbjct: 249 LDPNPATRITFAEVIENEWFKKGYKAPKF-ENADVSLDDVDAIFDD-SGESKNLVVERRE 306 Query: 305 EG---PLMMNAFEMITLSQGLNLSALFDRRQDFVKRQTRFVSRREPSEIIANIEAVANSM 361 EG P+ MNAFE+I+ SQGLNL +LF+++ VKR+TRF S+ +EI+ IEA A M Sbjct: 307 EGLKTPVTMNAFELISTSQGLNLGSLFEKQMGLVKRKTRFTSKSSANEIVTKIEAAAAPM 366 Query: 362 GFKSHTRNFKTRLEGLSSIKAGQLAVVIEIYEVAPSLFMVDVRKAAGETLEYHKFYKKLC 421 GF T N+K +L G S + GQLAV E+++VAPSL+MV++RK+ G+TLE+HKFYK L Sbjct: 367 GFDVKTNNYKMKLTGEKSGRKGQLAVATEVFQVAPSLYMVEMRKSGGDTLEFHKFYKNLT 426 Query: 422 SKLENIIWRATE 433 + L++I+W+ + Sbjct: 427 TGLKDIVWKTID 438 >2EHB-D nrPDB Length = 143 Score = 293 bits (751), Expect = 8e-80, Method: Compositional matrix adjust. Identities = 143/143 (100%), Positives = 143/143 (100%) Query: 304 DEGPLMMNAFEMITLSQGLNLSALFDRRQDFVKRQTRFVSRREPSEIIANIEAVANSMGF 363 DEGPLMMNAFEMITLSQGLNLSALFDRRQDFVKRQTRFVSRREPSEIIANIEAVANSMGF Sbjct: 1 DEGPLMMNAFEMITLSQGLNLSALFDRRQDFVKRQTRFVSRREPSEIIANIEAVANSMGF 60 Query: 364 KSHTRNFKTRLEGLSSIKAGQLAVVIEIYEVAPSLFMVDVRKAAGETLEYHKFYKKLCSK 423 KSHTRNFKTRLEGLSSIKAGQLAVVIEIYEVAPSLFMVDVRKAAGETLEYHKFYKKLCSK Sbjct: 61 KSHTRNFKTRLEGLSSIKAGQLAVVIEIYEVAPSLFMVDVRKAAGETLEYHKFYKKLCSK 120 Query: 424 LENIIWRATEGIPKSEILRTITF 446 LENIIWRATEGIPKSEILRTITF Sbjct: 121 LENIIWRATEGIPKSEILRTITF 143 >3H4J-B nrPDB Length = 336 Score = 275 bits (702), Expect = 3e-74, Method: Compositional matrix adjust. Identities = 136/327 (41%), Positives = 214/327 (65%), Gaps = 11/327 (3%) Query: 1 MTKKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREI 60 M R +G Y + T+GEG+F KVK A + T VA+K +++ + K+ M +++REI Sbjct: 1 MAISKRHIGPYIIRETLGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREI 60 Query: 61 SIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVD 120 S +K++RHP+I++LY+V+ +P+ I +V+E+ GGELFD IV K R+ E E R++FQQ++ Sbjct: 61 SYLKLLRHPHIIKLYDVITTPTDIVMVIEY-AGGELFDYIVEKKRMTEDEGRRFFQQIIC 119 Query: 121 AVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEV 180 A+ +CH + HRDLKPENLLLD N N+K++DFGLS + +G L+T+CG+PNY APEV Sbjct: 120 AIEYCHRHKIVHRDLKPENLLLDDNLNVKIADFGLSNIMTDG-NFLKTSCGSPNYAAPEV 178 Query: 181 LSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFL 240 ++G+ Y G D+WSCG++L+V+L G LPF + +P L++K+N+ + P + S + L Sbjct: 179 INGKLYAGPEVDVWSCGIVLYVMLVGRLPFDDEFIPNLFKKVNSCVYVMPDFLSPGAQSL 238 Query: 241 IHRILDPNPKTRIQIQGIKKDPWFRLNYVP--IRAREEEEVNLDDIRAVFD-----GIEG 293 I R++ +P RI IQ I++DPWF +N +P +R EE + + D R V G Sbjct: 239 IRRMIVADPMQRITIQEIRRDPWFNVN-LPDYLRPMEEVQGSYADSRIVSKLGEAMGFSE 297 Query: 294 SYVAENVERNDEGPLMMNAFEMITLSQ 320 Y+ E + R+DE + A+ ++ +Q Sbjct: 298 DYIVEAL-RSDENNEVKEAYNLLHENQ 323 >5EZV-A nrPDB Length = 560 Score = 265 bits (677), Expect = 3e-71, Method: Compositional matrix adjust. Identities = 122/259 (47%), Positives = 178/259 (68%), Gaps = 1/259 (0%) Query: 7 RVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIV 66 ++G Y +G T+G GTF KVK + TG VA+KI+ + I +V +IKREI +K+ Sbjct: 26 KIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLF 85 Query: 67 RHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCH 126 RHP+I++LY+V+++P+ ++V+E+V+GGELFD I GR+EE E+R+ FQQ++ AV +CH Sbjct: 86 RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCH 145 Query: 127 CKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGY 186 V HRDLKPEN+LLD + N K++DFGLS + +G E LRT+CG+PNY APEV+SG+ Y Sbjct: 146 RHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDG-EFLRTSCGSPNYAAPEVISGRLY 204 Query: 187 DGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILD 246 G DIWSCGVIL+ +L G LPF + +P L++KI F P + + V L+ +L Sbjct: 205 AGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQ 264 Query: 247 PNPKTRIQIQGIKKDPWFR 265 +P R I+ I++ WF+ Sbjct: 265 VDPLKRATIKDIREHEWFK 283 >4CFF-A nrPDB Length = 571 Score = 265 bits (677), Expect = 3e-71, Method: Compositional matrix adjust. Identities = 122/259 (47%), Positives = 178/259 (68%), Gaps = 1/259 (0%) Query: 7 RVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIV 66 ++G Y +G T+G GTF KVK + TG VA+KI+ + I +V +IKREI +K+ Sbjct: 31 KIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLF 90 Query: 67 RHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCH 126 RHP+I++LY+V+++P+ ++V+E+V+GGELFD I GR+EE E+R+ FQQ++ AV +CH Sbjct: 91 RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCH 150 Query: 127 CKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGY 186 V HRDLKPEN+LLD + N K++DFGLS + +G E LRT+CG+PNY APEV+SG+ Y Sbjct: 151 RHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDG-EFLRTSCGSPNYAAPEVISGRLY 209 Query: 187 DGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILD 246 G DIWSCGVIL+ +L G LPF + +P L++KI F P + + V L+ +L Sbjct: 210 AGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQ 269 Query: 247 PNPKTRIQIQGIKKDPWFR 265 +P R I+ I++ WF+ Sbjct: 270 VDPLKRATIKDIREHEWFK 288 >2YZA-A nrPDB Length = 276 Score = 261 bits (668), Expect = 3e-70, Method: Compositional matrix adjust. Identities = 121/259 (46%), Positives = 177/259 (68%), Gaps = 1/259 (0%) Query: 7 RVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIV 66 ++G Y +G T+G GTF KVK + TG VA+KI+ + I +V +IKREI +K+ Sbjct: 9 KIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLF 68 Query: 67 RHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCH 126 RHP+I++LY+V+++P+ ++V+E+V+GGELFD I GR+EE E+R+ FQQ++ AV +CH Sbjct: 69 RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCH 128 Query: 127 CKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGY 186 V HRDLKPEN+LLD + N K++DFGLS + +G E LR +CG+PNY APEV+SG+ Y Sbjct: 129 RHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDG-EFLRDSCGSPNYAAPEVISGRLY 187 Query: 187 DGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILD 246 G DIWSCGVIL+ +L G LPF + +P L++KI F P + + V L+ +L Sbjct: 188 AGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQ 247 Query: 247 PNPKTRIQIQGIKKDPWFR 265 +P R I+ I++ WF+ Sbjct: 248 VDPLKRATIKDIREHEWFK 266 >4REW-A nrPDB Length = 540 Score = 261 bits (668), Expect = 3e-70, Method: Compositional matrix adjust. Identities = 122/259 (47%), Positives = 178/259 (68%), Gaps = 1/259 (0%) Query: 7 RVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIV 66 ++G Y +G T+G GTF KVK ++ TG VA+KI+ + I +V +I+REI +K+ Sbjct: 4 KIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLF 63 Query: 67 RHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCH 126 RHP+I++LY+V+++PS I++V+E+V+GGELFD I GRL+E ESR+ FQQ++ V +CH Sbjct: 64 RHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCH 123 Query: 127 CKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGY 186 V HRDLKPEN+LLD + N K++DFGLS + +G E LRT+CG+PNY APEV+SG+ Y Sbjct: 124 RHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDG-EFLRTSCGSPNYAAPEVISGRLY 182 Query: 187 DGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILD 246 G DIWS GVIL+ +L G LPF + +P L++KI F P + + V L+ +L Sbjct: 183 AGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQ 242 Query: 247 PNPKTRIQIQGIKKDPWFR 265 +P R I+ I++ WF+ Sbjct: 243 VDPMKRASIKDIREHEWFK 261 >3MN3-A nrPDB Length = 271 Score = 261 bits (667), Expect = 4e-70, Method: Compositional matrix adjust. Identities = 120/261 (45%), Positives = 183/261 (70%), Gaps = 2/261 (0%) Query: 7 RVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIV 66 +G Y++ +T+GEG+F KVK A +T TG VA+KI+ K + K+ M +I+REIS ++++ Sbjct: 2 HIGNYQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLL 61 Query: 67 RHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCH 126 RHP+I++LY+V+ S +I +V+E+ G ELFD IV + ++ E E+R++FQQ++ AV +CH Sbjct: 62 RHPHIIKLYDVIKSKDEIIMVIEY-AGNELFDYIVQRDKMSEQEARRFFQQIISAVEYCH 120 Query: 127 CKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGY 186 + HRDLKPENLLLD + N+K++DFGLS + +G L+T+CG+PNY APEV+SG+ Y Sbjct: 121 RHKIVHRDLKPENLLLDEHLNVKIADFGLSNIMTDG-NFLKTSCGSPNYAAPEVISGKLY 179 Query: 187 DGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILD 246 G D+WSCGVIL+V+L LPF + +P L++ I+ ++ P + S LI R+L Sbjct: 180 AGPEVDVWSCGVILYVMLCRRLPFDDESIPVLFKNISNGVYTLPKFLSPGAAGLIKRMLI 239 Query: 247 PNPKTRIQIQGIKKDPWFRLN 267 NP RI I I +D WF+++ Sbjct: 240 VNPLNRISIHEIMQDDWFKVD 260 >4CFH-A nrPDB Length = 493 Score = 261 bits (666), Expect = 6e-70, Method: Compositional matrix adjust. Identities = 122/259 (47%), Positives = 178/259 (68%), Gaps = 1/259 (0%) Query: 7 RVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIV 66 ++G Y +G T+G GTF KVK ++ TG VA+KI+ + I +V +I+REI +K+ Sbjct: 31 KIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLF 90 Query: 67 RHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCH 126 RHP+I++LY+V+++PS I++V+E+V+GGELFD I GRL+E ESR+ FQQ++ V +CH Sbjct: 91 RHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCH 150 Query: 127 CKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGY 186 V HRDLKPEN+LLD + N K++DFGLS + +G E LRT+CG+PNY APEV+SG+ Y Sbjct: 151 RHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDG-EFLRTSCGSPNYAAPEVISGRLY 209 Query: 187 DGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILD 246 G DIWS GVIL+ +L G LPF + +P L++KI F P + + V L+ +L Sbjct: 210 AGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQ 269 Query: 247 PNPKTRIQIQGIKKDPWFR 265 +P R I+ I++ WF+ Sbjct: 270 VDPMKRATIKDIREHEWFK 288 >4RED-A nrPDB Length = 351 Score = 260 bits (665), Expect = 7e-70, Method: Compositional matrix adjust. Identities = 122/259 (47%), Positives = 178/259 (68%), Gaps = 1/259 (0%) Query: 7 RVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIV 66 ++G Y +G T+G GTF KVK ++ TG VA+KI+ + I +V +I+REI +K+ Sbjct: 12 KIGHYILGDTLGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVVGKIRREIQNLKLF 71 Query: 67 RHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCH 126 RHP+I++LY+V+++PS I++V+E+V+GGELFD I GRL+E ESR+ FQQ++ V +CH Sbjct: 72 RHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCH 131 Query: 127 CKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGY 186 V HRDLKPEN+LLD + N K++DFGLS + +G E LRT+CG+PNY APEV+SG+ Y Sbjct: 132 RHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDG-EFLRTSCGSPNYAAPEVISGRLY 190 Query: 187 DGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILD 246 G DIWS GVIL+ +L G LPF + +P L++KI F P + + V L+ +L Sbjct: 191 AGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQ 250 Query: 247 PNPKTRIQIQGIKKDPWFR 265 +P R I+ I++ WF+ Sbjct: 251 VDPMKRASIKDIREHEWFK 269 >4CQG-A nrPDB Length = 331 Score = 234 bits (597), Expect = 5e-62, Method: Compositional matrix adjust. Identities = 114/259 (44%), Positives = 169/259 (65%), Gaps = 3/259 (1%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 YE+ TIG G FAKVK A + TG+ VAIKIM K+ + + + ++K EI +K +RH + Sbjct: 11 YELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGSD--LPRVKTEIDALKSLRHQH 68 Query: 71 IVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGV 130 I +LY VL + +KI++VLE+ GGELFD I+ + RL E E+R F+Q++ AVA+ H +G Sbjct: 69 ICQLYHVLETKNKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQILSAVAYVHSQGY 128 Query: 131 YHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVEL-LRTTCGTPNYVAPEVLSGQGYDGS 189 HRDLKPENLL D N LK+ DFGL A P+ + L+ CG+ Y APE++ G+ Y GS Sbjct: 129 AHRDLKPENLLFDENHKLKLIDFGLCAKPKGNKDYHLQECCGSLAYAAPELIQGKSYLGS 188 Query: 190 AADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILDPNP 249 AD+WS G++L+V++ G+LPF + ++ LY+KI ++ P W S L+ ++L +P Sbjct: 189 EADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYEVPKWLSPSSILLLQQMLQVDP 248 Query: 250 KTRIQIQGIKKDPWFRLNY 268 K RI ++ + PW +Y Sbjct: 249 KKRISMRNLLNHPWVMQDY 267 >5ES1-A nrPDB Length = 328 Score = 234 bits (596), Expect = 7e-62, Method: Compositional matrix adjust. Identities = 116/261 (44%), Positives = 167/261 (63%), Gaps = 2/261 (0%) Query: 8 VGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR 67 VG Y + RTIG+G FAKVK AR+ TG VAIKI+ K T L + ++ RE+ IMK + Sbjct: 14 VGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDK-TQLNPSSLQKLFREVRIMKGLN 72 Query: 68 HPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHC 127 HPNIV+L+EV+ + +Y+V+E+ + GE+FD +V GR++E E+R F+Q+V AV +CH Sbjct: 73 HPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQ 132 Query: 128 KGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYD 187 K + HRDLK ENLLLD N+K++DFG S G + L T CG+P Y APE+ G+ YD Sbjct: 133 KNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSK-LDTFCGSPPYAAPELFQGKKYD 191 Query: 188 GSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILDP 247 G DIWS GVIL+ +++G LPF +L L ++ ++ P + S + + ++ R L Sbjct: 192 GPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVL 251 Query: 248 NPKTRIQIQGIKKDPWFRLNY 268 NP R ++ I KD W + Y Sbjct: 252 NPAKRCTLEQIMKDKWINIGY 272 >5KZ7-A nrPDB Length = 346 Score = 231 bits (589), Expect = 5e-61, Method: Compositional matrix adjust. Identities = 112/262 (42%), Positives = 171/262 (65%), Gaps = 2/262 (0%) Query: 7 RVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIV 66 +G Y + +TIG+G FAKVK AR+ TG VA+KI+ K T L + + ++ RE+ IMK++ Sbjct: 31 HIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDK-TQLNSSSLQKLFREVRIMKVL 89 Query: 67 RHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCH 126 HPNIV+L+EV+ + +Y+V+E+ +GGE+FD +V GR++E E+R F+Q+V AV +CH Sbjct: 90 NHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCH 149 Query: 127 CKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGY 186 K + HRDLK ENLLLD + N+K++DFG S G + L T CG+P Y APE+ G+ Y Sbjct: 150 QKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNK-LDTFCGSPPYAAPELFQGKKY 208 Query: 187 DGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILD 246 DG D+WS GVIL+ +++G LPF +L L ++ ++ P + S + + L+ + L Sbjct: 209 DGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLI 268 Query: 247 PNPKTRIQIQGIKKDPWFRLNY 268 NP R ++ I KD W + + Sbjct: 269 LNPSKRGTLEQIMKDRWMNVGH 290 >4D2V-A nrPDB Length = 356 Score = 231 bits (588), Expect = 7e-61, Method: Compositional matrix adjust. Identities = 119/276 (43%), Positives = 173/276 (62%), Gaps = 5/276 (1%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 YE+ TIG G FAKVK A + TG+ VAIKIM K+T+ + + +IK EI +K +RH + Sbjct: 31 YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSD--LPRIKTEIEALKNLRHQH 88 Query: 71 IVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGV 130 I +LY VL + +KI++VLE+ GGELFD I+ + RL E E+R F+Q+V AVA+ H +G Sbjct: 89 ICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGY 148 Query: 131 YHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVEL-LRTTCGTPNYVAPEVLSGQGYDGS 189 HRDLKPENLL D LK+ DFGL A P+ + L+ CG Y APE++ G+ Y GS Sbjct: 149 AHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQACCGALAYAAPELIQGKSYLGS 208 Query: 190 AADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILDPNP 249 AD+WS G++L+V++ G+LPF + L KI ++ P W S L+ ++L +P Sbjct: 209 EADVWSMGILLYVLMCGFLPFDDDTAAALVAKIMRGKYDVPKWLSPSSILLLQQMLQVDP 268 Query: 250 KTRIQIQGIKKDPWFRLNY-VPIRAREEEE-VNLDD 283 K RI ++ + PW +Y P+ + + ++LDD Sbjct: 269 KKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDD 304 >4YNZ-A nrPDB Length = 342 Score = 230 bits (587), Expect = 8e-61, Method: Compositional matrix adjust. Identities = 107/260 (41%), Positives = 172/260 (66%), Gaps = 2/260 (0%) Query: 5 MRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMK 64 M+ VG Y + +T+G+G VK + T VAIKI+ + L ++ +++REI+I+K Sbjct: 6 MQYVGPYRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREK-LSESVLMKVEREIAILK 64 Query: 65 IVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAH 124 ++ HP++++L++V + +Y+VLE V+GGELFD +V KGRL E+RK+F+Q++ A+ Sbjct: 65 LIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDF 124 Query: 125 CHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQ 184 CH + HRDLKPENLLLD N++++DFG+++L Q G LL T+CG+P+Y PEV+ G+ Sbjct: 125 CHSHSICHRDLKPENLLLDERNNIRIADFGMASL-QVGDSLLETSCGSPHYACPEVIRGE 183 Query: 185 GYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRI 244 YDG AD+WSCGVILF +L G LPF + +L L K+ F P + + + L+ + Sbjct: 184 KYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGM 243 Query: 245 LDPNPKTRIQIQGIKKDPWF 264 ++ + R+ ++ I+K W+ Sbjct: 244 IEVDAARRLTLEHIQKHIWY 263 >2QNJ-A nrPDB Length = 328 Score = 230 bits (587), Expect = 8e-61, Method: Compositional matrix adjust. Identities = 114/256 (44%), Positives = 168/256 (65%), Gaps = 2/256 (0%) Query: 8 VGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR 67 +G Y + +TIG+G FAKVK AR+ TG VAIKI+ K T L + ++ RE+ IMKI+ Sbjct: 11 IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDK-TQLNPTSLQKLFREVRIMKILN 69 Query: 68 HPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHC 127 HPNIV+L+EV+ + +Y+++E+ +GGE+FD +V GR++E E+R F+Q+V AV +CH Sbjct: 70 HPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQ 129 Query: 128 KGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYD 187 K + HRDLK ENLLLD + N+K++DFG S G + L T CG+P Y APE+ G+ YD Sbjct: 130 KRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGK-LDTFCGSPPYAAPELFQGKKYD 188 Query: 188 GSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILDP 247 G D+WS GVIL+ +++G LPF +L L ++ ++ P + S + + L+ R L Sbjct: 189 GPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVL 248 Query: 248 NPKTRIQIQGIKKDPW 263 NP R ++ I KD W Sbjct: 249 NPIKRGTLEQIMKDRW 264 >2HAK-A nrPDB Length = 328 Score = 223 bits (569), Expect = 9e-59, Method: Compositional matrix adjust. Identities = 118/278 (42%), Positives = 178/278 (64%), Gaps = 8/278 (2%) Query: 2 TKKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREIS 61 T + +G Y + +TIG+G FAKVK AR+ TG VA+KI+ K T L + ++ RE+ Sbjct: 8 TDEQPHIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDK-TQLNPTSLQKLFREVR 66 Query: 62 IMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDA 121 IMKI+ HPNIV+L+EV+ + +Y+V+E+ +GGE+FD +V GR++E E+R F+Q+V A Sbjct: 67 IMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSA 126 Query: 122 VAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVL 181 V +CH K + HRDLK ENLLLD + N+K++DFG S G + L T CG+P Y APE+ Sbjct: 127 VQYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNK-LDTFCGSPPYAAPELF 185 Query: 182 SGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLI 241 G+ YDG D+WS GVIL+ +++G LPF +L L ++ ++ P + S + + L+ Sbjct: 186 QGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLL 245 Query: 242 HRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEV 279 ++L NP R ++ I KD W + + EEEE+ Sbjct: 246 KKLLVLNPIKRGSLEQIMKDRWMNVGH------EEEEL 277 >6C9D-A nrPDB Length = 459 Score = 221 bits (563), Expect = 5e-58, Method: Compositional matrix adjust. Identities = 117/278 (42%), Positives = 177/278 (63%), Gaps = 8/278 (2%) Query: 2 TKKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREIS 61 T + +G Y + +TIG+G FAKVK AR+ TG VA+KI+ K T L + ++ RE+ Sbjct: 14 TDEQPHIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDK-TQLNPTSLQKLFREVR 72 Query: 62 IMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDA 121 IMKI+ HPNIV+L+EV+ + +Y+V+E+ +GGE+FD +V GR++E E+R F+Q+V A Sbjct: 73 IMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSA 132 Query: 122 VAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVL 181 V +CH K + HRDLK ENLLLD + N+K++DFG S G + L CG+P Y APE+ Sbjct: 133 VQYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNK-LDEFCGSPPYAAPELF 191 Query: 182 SGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLI 241 G+ YDG D+WS GVIL+ +++G LPF +L L ++ ++ P + S + + L+ Sbjct: 192 QGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLL 251 Query: 242 HRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEV 279 ++L NP R ++ I KD W + + EEEE+ Sbjct: 252 KKLLVLNPIKRGSLEQIMKDRWMNVGH------EEEEL 283 >5WAX-A nrPDB Length = 310 Score = 213 bits (543), Expect = 1e-55, Method: Compositional matrix adjust. Identities = 116/271 (42%), Positives = 160/271 (59%), Gaps = 13/271 (4%) Query: 5 MRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMK 64 M +YE+ R IG G F + RN G VA+K + + ++ + ++REI + Sbjct: 7 MHDGDRYELVRDIGSGNFGVARLMRNRADGQLVAVKYIERG----EKIDENVQREIINHR 62 Query: 65 IVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAH 124 +RHPNI+R EV+ +P+ + IV+E+ +GGELF+RI + GR E E+R +FQQL+ V++ Sbjct: 63 SLRHPNIIRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSY 122 Query: 125 CHCKGVYHRDLKPENLLLD--TNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLS 182 CH V HRDLK EN LLD T LK+ DFG S + ++T GTP Y+APEVL Sbjct: 123 CHSMQVCHRDLKLENTLLDGSTAPRLKICDFGYSKSSVLHSQ-PKSTVGTPAYIAPEVLL 181 Query: 183 GQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRK----INAAEFSCPPW--FSAE 236 + YDG AD+WSCGV L+V+L G PF + D P +RK I ++S P + S E Sbjct: 182 KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILGVQYSIPDYVHISPE 241 Query: 237 VKFLIHRILDPNPKTRIQIQGIKKDPWFRLN 267 + LI RI NP TRI I I+ PWF N Sbjct: 242 CQDLISRIFVANPATRITIPEIRNHPWFLKN 272 >5YKS-A nrPDB Length = 377 Score = 213 bits (541), Expect = 2e-55, Method: Compositional matrix adjust. Identities = 111/259 (42%), Positives = 164/259 (63%), Gaps = 4/259 (1%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 G Y++ +T+G G FA VK AR+ TG+ VA+K++ K T L + +E+ MK+V+H Sbjct: 35 GLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDK-TKLDTLATGHLFQEVRCMKLVQH 93 Query: 69 PNIVRLYEVLASPSKIYIVLEFVTGGELFDRIV-HKGRLEESESRKYFQQLVDAVAHCHC 127 PNIVRLYEV+ + +K+Y++LE GG++FD I+ H+ L E ++KYF Q+V A+++CH Sbjct: 94 PNIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHK 153 Query: 128 KGVYHRDLKPENLLL-DTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGY 186 V HRDLKPEN++ + G +K++DFG S Q G +L T+CG+ Y APE+L G Y Sbjct: 154 LHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKL-TTSCGSLAYSAPEILLGDEY 212 Query: 187 DGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILD 246 D A DIWS GVILF+++ G PF E + I +++ P S E K LI R+L Sbjct: 213 DAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRMLQ 272 Query: 247 PNPKTRIQIQGIKKDPWFR 265 +PK R ++ I+ PW + Sbjct: 273 RDPKRRASLEEIENHPWLQ 291 >3UC3-A nrPDB Length = 361 Score = 198 bits (503), Expect = 4e-51, Method: Compositional matrix adjust. Identities = 110/271 (40%), Positives = 157/271 (57%), Gaps = 13/271 (4%) Query: 5 MRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMK 64 M +Y+ + IG G F + R+ T + VA+K + + + + ++REI + Sbjct: 16 MHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGAAID----ENVQREIINHR 71 Query: 65 IVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAH 124 +RHPNIVR EV+ +P+ + I++E+ +GGEL++RI + GR E E+R +FQQL+ V++ Sbjct: 72 SLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSY 131 Query: 125 CHCKGVYHRDLKPENLLLDTN--GNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLS 182 CH + HRDLK EN LLD + LK+ DFG S + ++T GTP Y+APEVL Sbjct: 132 CHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQ-PKSTVGTPAYIAPEVLL 190 Query: 183 GQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRK----INAAEFSCPP--WFSAE 236 Q YDG AD+WSCGV L+V+L G PF + + P YRK I + ++S P S E Sbjct: 191 RQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPE 250 Query: 237 VKFLIHRILDPNPKTRIQIQGIKKDPWFRLN 267 LI RI +P TRI I IK WF N Sbjct: 251 CCHLISRIFVADPATRISIPEIKTHSWFLKN 281 >3ZUT-A nrPDB Length = 362 Score = 198 bits (503), Expect = 5e-51, Method: Compositional matrix adjust. Identities = 108/271 (39%), Positives = 158/271 (58%), Gaps = 13/271 (4%) Query: 5 MRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMK 64 M +YE+ + IG G F + R+ + + VA+K + + ++ + +KREI + Sbjct: 15 MHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERG----EKIDENVKREIINHR 70 Query: 65 IVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAH 124 +RHPNIVR EV+ +P+ + IV+E+ +GGELF+RI + GR E E+R +FQQL+ V++ Sbjct: 71 SLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSY 130 Query: 125 CHCKGVYHRDLKPENLLLDTN--GNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLS 182 CH V HRDLK EN LLD + LK+ FG S + ++T GTP Y+APEVL Sbjct: 131 CHAMQVCHRDLKLENTLLDGSPAPRLKICAFGYSKSSVLHSQ-PKSTVGTPAYIAPEVLL 189 Query: 183 GQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRK----INAAEFSCPPW--FSAE 236 + YDG AD+WSCGV L+V+L G PF + + P +RK I +++ P + S E Sbjct: 190 KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPE 249 Query: 237 VKFLIHRILDPNPKTRIQIQGIKKDPWFRLN 267 + LI RI +P RI I I+ WF N Sbjct: 250 CRHLISRIFVADPAKRISIPEIRNHEWFLKN 280 >3UDB-A nrPDB Length = 317 Score = 197 bits (500), Expect = 1e-50, Method: Compositional matrix adjust. Identities = 107/271 (39%), Positives = 157/271 (57%), Gaps = 13/271 (4%) Query: 5 MRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMK 64 M +YE+ + IG G F + R+ + VA+K + + ++ + +KREI + Sbjct: 15 MHDSDRYELVKDIGAGNFGVARLMRDKQANELVAVKYIERG----EKIDENVKREIINHR 70 Query: 65 IVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAH 124 +RHPNIVR EV+ +P+ + IV+E+ +GGELF+RI + GR E E+R +FQQL+ V++ Sbjct: 71 SLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSY 130 Query: 125 CHCKGVYHRDLKPENLLLDTN--GNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLS 182 H V HRDLK EN LLD + LK++DFG S + ++ GTP Y+APEVL Sbjct: 131 AHAMQVAHRDLKLENTLLDGSPAPRLKIADFGYSKASVLHSQ-PKSAVGTPAYIAPEVLL 189 Query: 183 GQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRK----INAAEFSCPPW--FSAE 236 + YDG AD+WSCGV L+V+L G PF + + P +RK I +++ P + S E Sbjct: 190 KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPE 249 Query: 237 VKFLIHRILDPNPKTRIQIQGIKKDPWFRLN 267 + LI RI +P RI I I+ WF N Sbjct: 250 CRHLISRIFVADPAKRISIPEIRNHEWFLKN 280 >5IG1-A nrPDB Length = 344 Score = 196 bits (498), Expect = 2e-50, Method: Compositional matrix adjust. Identities = 105/261 (40%), Positives = 154/261 (59%), Gaps = 10/261 (3%) Query: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYE 76 IG+G F+ V N TG+ A+K++A + L++ +++IKREI I ++H +IV + Sbjct: 25 IGKGAFSTVHRCVNKRTGEVCAVKVIALKS-LRSSEINKIKREIGICSSLQHEHIVSMRR 83 Query: 77 VLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDLK 136 S Y+V E+V+GGELFD IV + E ++ Q++ A+ HCH K + HRDLK Sbjct: 84 AFRDESHFYLVFEYVSGGELFDEIVTRKFYNEKDASACMHQILSALQHCHSKNIIHRDLK 143 Query: 137 PENLLL---DTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSAADI 193 PENLLL D N +K++DFGL+ + ++G GTP Y++PEV+ YD +A D+ Sbjct: 144 PENLLLASKDPNAPVKITDFGLAVIMEQGPTYF-GFAGTPGYLSPEVIRRVPYD-TAVDV 201 Query: 194 WSCGVILFVILAGYLPFSETDLPGLYRKINAAE--FSCPPWFS--AEVKFLIHRILDPNP 249 W+CGVIL+++L GY PF E D LY +I + F P W S K LI +L+PNP Sbjct: 202 WACGVILYILLVGYPPFWEEDHQKLYAQIKNCQYDFPSPEWDSVTTAAKELIKAMLEPNP 261 Query: 250 KTRIQIQGIKKDPWFRLNYVP 270 K R +Q + + PW VP Sbjct: 262 KRRPTVQELLQHPWIARRDVP 282 >4B8L-A nrPDB Length = 286 Score = 191 bits (486), Expect = 4e-49, Method: Compositional matrix adjust. Identities = 94/267 (35%), Positives = 150/267 (56%), Gaps = 3/267 (1%) Query: 1 MTKKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREI 60 M K+ + +++GR +G+G F V AR +A+K++ KS + K + Q++REI Sbjct: 7 MPKRKFTIDDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRREI 66 Query: 61 SIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVD 120 I +RHPNI+R+Y +IY++LEF GEL+ + GR +E S + ++L D Sbjct: 67 EIQSHLRHPNILRMYNYFHDRKRIYLMLEFAPRGELYKELQKHGRFDEQRSATFMEELAD 126 Query: 121 AVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEV 180 A+ +CH + V HRD+KPENLL+ G LK++DFG S RT CGT +Y+ PE+ Sbjct: 127 ALHYCHERKVIHRDIKPENLLMGYKGELKIADFGWSV--HAPSLRRRTMCGTLDYLPPEM 184 Query: 181 LSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFL 240 + G+ +D D+W GV+ + L G PF +R+I + PP+ S K L Sbjct: 185 IEGKTHD-EKVDLWCAGVLCYEFLVGMPPFDSPSHTETHRRIVNVDLKFPPFLSDGSKDL 243 Query: 241 IHRILDPNPKTRIQIQGIKKDPWFRLN 267 I ++L +P R+ ++G+ + PW + N Sbjct: 244 ISKLLRYHPPQRLPLKGVMEHPWVKAN 270 >2JC6-A nrPDB Length = 334 Score = 189 bits (480), Expect = 2e-48, Method: Compositional matrix adjust. Identities = 102/260 (39%), Positives = 153/260 (58%), Gaps = 11/260 (4%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 +E T+G G F++V A TG A+K + K LK + I+ EI++++ ++H N Sbjct: 24 FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKA-LKGKE-SSIENEIAVLRKIKHEN 81 Query: 71 IVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGV 130 IV L ++ SP+ +Y+V++ V+GGELFDRIV KG E ++ +Q++DAV + H G+ Sbjct: 82 IVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGI 141 Query: 131 YHRDLKPENLLL---DTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYD 187 HRDLKPENLL D + +SDFGLS + +G +++ T CGTP YVAPEVL+ + Y Sbjct: 142 VHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKG-DVMSTACGTPGYVAPEVLAQKPY- 199 Query: 188 GSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAA--EFSCPPW--FSAEVKFLIHR 243 A D WS GVI +++L GY PF + + L+ +I A EF P W S K I Sbjct: 200 SKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRN 259 Query: 244 ILDPNPKTRIQIQGIKKDPW 263 +++ +P R + + PW Sbjct: 260 LMEKDPNKRYTCEQAARHPW 279 >3BHH-A nrPDB Length = 295 Score = 185 bits (470), Expect = 3e-47, Method: Compositional matrix adjust. Identities = 103/261 (39%), Positives = 153/261 (58%), Gaps = 9/261 (3%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 +Y++ IG+G F+ V+ TG A KI+ + L R +++RE I ++++H Sbjct: 5 EYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKII-NTKKLSARDHQKLEREARICRLLKHS 63 Query: 70 NIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKG 129 NIVRL++ ++ Y+V + VTGGELF+ IV + E+++ QQ+++AV HCH G Sbjct: 64 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMG 123 Query: 130 VYHRDLKPENLLLDT---NGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGY 186 V HRDLKPENLLL + +K++DFGL+ Q + GTP Y++PEVL + Y Sbjct: 124 VVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAY 183 Query: 187 DGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAA--EFSCPPW--FSAEVKFLIH 242 G DIW+CGVIL+++L GY PF + D LY++I A +F P W + E K LI+ Sbjct: 184 -GKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLIN 242 Query: 243 RILDPNPKTRIQIQGIKKDPW 263 ++L NP RI K PW Sbjct: 243 QMLTINPAKRITAHEALKHPW 263 >2VN9-A nrPDB Length = 301 Score = 185 bits (469), Expect = 4e-47, Method: Compositional matrix adjust. Identities = 100/261 (38%), Positives = 153/261 (58%), Gaps = 9/261 (3%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 +Y++ +G+G F+ V+ TG A KI+ + L R +++RE I ++++HP Sbjct: 5 EYQLFEELGKGAFSVVRRCMKIPTGQEYAAKII-NTKKLSARDHQKLEREARICRLLKHP 63 Query: 70 NIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKG 129 NIVRL++ ++ Y+V + VTGGELF+ IV + E+++ QQ++++V HCH G Sbjct: 64 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNG 123 Query: 130 VYHRDLKPENLLLDTNGN---LKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGY 186 + HRDLKPENLLL + +K++DFGL+ Q + GTP Y++PEVL Y Sbjct: 124 IVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPY 183 Query: 187 DGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAA--EFSCPPW--FSAEVKFLIH 242 G D+W+CGVIL+++L GY PF + D LY++I A +F P W + E K LI+ Sbjct: 184 -GKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLIN 242 Query: 243 RILDPNPKTRIQIQGIKKDPW 263 ++L NP RI K PW Sbjct: 243 KMLTINPAKRITASEALKHPW 263 >4FG9-A nrPDB Length = 320 Score = 185 bits (469), Expect = 4e-47, Method: Compositional matrix adjust. Identities = 101/260 (38%), Positives = 151/260 (58%), Gaps = 11/260 (4%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 Y+ +G G F++V A + T VAIK +AK + ++ EI+++ ++HPN Sbjct: 20 YDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKE--GSMENEIAVLHKIKHPN 77 Query: 71 IVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGV 130 IV L ++ S +Y++++ V+GGELFDRIV KG E ++ + Q++DAV + H G+ Sbjct: 78 IVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLGI 137 Query: 131 YHRDLKPENLL---LDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYD 187 HRDLKPENLL LD + + +SDFGLS + G +L T CGTP YVAPEVL+ + Y Sbjct: 138 VHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPG-SVLSTACGTPGYVAPEVLAQKPY- 195 Query: 188 GSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAA--EFSCPPW--FSAEVKFLIHR 243 A D WS GVI +++L GY PF + + L+ +I A EF P W S K I Sbjct: 196 SKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIRH 255 Query: 244 ILDPNPKTRIQIQGIKKDPW 263 +++ +P+ R + + PW Sbjct: 256 LMEKDPEKRFTCEQALQHPW 275 >3D2K-A nrPDB Length = 272 Score = 184 bits (466), Expect = 8e-47, Method: Compositional matrix adjust. Identities = 91/267 (34%), Positives = 153/267 (57%), Gaps = 5/267 (1%) Query: 2 TKKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREIS 61 +K+ + +++GR +G+G F V AR + +A+K++ K+ + K + Q++RE+ Sbjct: 5 SKRQWTLEDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVEHQLRREVE 64 Query: 62 IMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDA 121 I +RHPNI+RLY +++Y++LE+ G ++ + R +E + Y +L +A Sbjct: 65 IQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSRFDEQRTATYITELANA 124 Query: 122 VAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTT-CGTPNYVAPEV 180 +++CH K V HRD+KPENLLL +NG LK++DFG S RTT CGT +Y+ PE+ Sbjct: 125 LSYCHSKRVIHRDIKPENLLLGSNGELKIADFGWSV---HAPSSRRTTLCGTLDYLPPEM 181 Query: 181 LSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFL 240 + G+ +D D+WS GV+ + L G PF YR+I+ EF+ P + + + L Sbjct: 182 IEGRMHD-EKVDLWSLGVLCYEFLVGMPPFEAHTYQETYRRISRVEFTFPDFVTEGARDL 240 Query: 241 IHRILDPNPKTRIQIQGIKKDPWFRLN 267 I R+L N R+ + + + PW + N Sbjct: 241 ISRLLKHNASQRLTLAEVLEHPWIKAN 267 >5FG8-A nrPDB Length = 285 Score = 184 bits (466), Expect = 1e-46, Method: Compositional matrix adjust. Identities = 102/260 (39%), Positives = 151/260 (58%), Gaps = 9/260 (3%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 Y++ +G+G F+ VK TG A KI+ + L R +++RE I + + HPN Sbjct: 16 YDIKEELGKGAFSIVKRCVQKSTGFEFAAKII-NTKKLTARDFQKLEREARICRKLHHPN 74 Query: 71 IVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGV 130 IVRL++ + + Y+V + VTGGELF+ IV + E+++ QQ++++V HCH GV Sbjct: 75 IVRLHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQNGV 134 Query: 131 YHRDLKPENLLLDTNGN---LKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYD 187 HRDLKPENLLL + +K++DFGL+ Q + GTP Y++PEVL + Y Sbjct: 135 VHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKEPY- 193 Query: 188 GSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAA--EFSCPPW--FSAEVKFLIHR 243 G + DIW+CGVIL+++L GY PF + D LY +I A ++ P W + E K LI++ Sbjct: 194 GKSVDIWACGVILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQ 253 Query: 244 ILDPNPKTRIQIQGIKKDPW 263 +L NP RI K PW Sbjct: 254 MLTVNPNKRITAAEALKHPW 273 >3F3Z-A nrPDB Length = 277 Score = 182 bits (463), Expect = 2e-46, Method: Compositional matrix adjust. Identities = 109/262 (41%), Positives = 155/262 (59%), Gaps = 15/262 (5%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 Y + TIG G++ +VK A T A K + K + VD+ K+EI IMK + HPN Sbjct: 11 YTLENTIGRGSWGEVKIAVQKGTRIRRAAKKIPKYFV---EDVDRFKQEIEIMKSLDHPN 67 Query: 71 IVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGV 130 I+RLYE + IY+V+E TGGELF+R+VHK ES++ + + ++ AVA+CH V Sbjct: 68 IIRLYETFEDNTDIYLVMELCTGGELFERVVHKRVFRESDAARIMKDVLSAVAYCHKLNV 127 Query: 131 YHRDLKPENLLLDT---NGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYD 187 HRDLKPEN L T + LK+ DFGL+A + G +++RT GTP YV+P+VL +G Sbjct: 128 AHRDLKPENFLFLTDSPDSPLKLIDFGLAARFKPG-KMMRTKVGTPYYVSPQVL--EGLY 184 Query: 188 GSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPP--WF--SAEVKFLIHR 243 G D WS GV+++V+L GY PFS + KI F+ P W S + + LI R Sbjct: 185 GPECDEWSAGVMMYVLLCGYPPFSAPTDSEVMLKIREGTFTFPEKDWLNVSPQAESLIRR 244 Query: 244 ILDPNPKTRI-QIQGIKKDPWF 264 +L +PK RI +Q ++ + WF Sbjct: 245 LLTKSPKQRITSLQALEHE-WF 265 >5U6Y-A nrPDB Length = 461 Score = 181 bits (459), Expect = 5e-46, Method: Compositional matrix adjust. Identities = 99/260 (38%), Positives = 151/260 (58%), Gaps = 9/260 (3%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 Y++ +G+G F+ V+ G A KI+ + L R +++RE I ++++HPN Sbjct: 2 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKII-NTKKLSARDHQKLEREARICRLLKHPN 60 Query: 71 IVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGV 130 IVRL++ ++ Y++ + VTGGELF+ IV + E+++ QQ+++AV HCH GV Sbjct: 61 IVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGV 120 Query: 131 YHRDLKPENLLLDT---NGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYD 187 HRDLKPENLLL + +K++DFGL+ + + GTP Y++PEVL Y Sbjct: 121 VHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPY- 179 Query: 188 GSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAA--EFSCPPW--FSAEVKFLIHR 243 G D+W+CGVIL+++L GY PF + D LY++I A +F P W + E K LI++ Sbjct: 180 GKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINK 239 Query: 244 ILDPNPKTRIQIQGIKKDPW 263 +L NP RI K PW Sbjct: 240 MLTINPSKRITAAEALKHPW 259 >4UZD-A nrPDB Length = 287 Score = 181 bits (458), Expect = 7e-46, Method: Compositional matrix adjust. Identities = 90/266 (33%), Positives = 151/266 (56%), Gaps = 5/266 (1%) Query: 3 KKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISI 62 K+ + +E+GR +G+G F V AR + +A+K++ K+ + K + Q++RE+ I Sbjct: 2 KRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEI 61 Query: 63 MKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAV 122 +RHPNI+RLY +++Y++LE+ G ++ + + +E + Y +L +A+ Sbjct: 62 QSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANAL 121 Query: 123 AHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTT-CGTPNYVAPEVL 181 ++CH K V HRD+KPENLLL + G LK++DFG S RTT CGT +Y+ PE++ Sbjct: 122 SYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSV---HAPSSRRTTLCGTLDYLPPEMI 178 Query: 182 SGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLI 241 G+ +D D+WS GV+ + L G PF Y++I+ EF+ P + + + LI Sbjct: 179 EGRMHD-EKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLI 237 Query: 242 HRILDPNPKTRIQIQGIKKDPWFRLN 267 R+L NP R ++ + + PW N Sbjct: 238 SRLLKHNPSQRPMLREVLEHPWITAN 263 >2VZ6-A nrPDB Length = 313 Score = 181 bits (458), Expect = 7e-46, Method: Compositional matrix adjust. Identities = 99/260 (38%), Positives = 151/260 (58%), Gaps = 9/260 (3%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 Y++ +G+G F+ V+ G A KI+ + L R +++RE I ++++HPN Sbjct: 24 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKII-NTKKLSARDHQKLEREARICRLLKHPN 82 Query: 71 IVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGV 130 IVRL++ ++ Y++ + VTGGELF+ IV + E+++ QQ+++AV HCH GV Sbjct: 83 IVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGV 142 Query: 131 YHRDLKPENLLLDT---NGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYD 187 HRDLKPENLLL + +K++DFGL+ + + GTP Y++PEVL Y Sbjct: 143 VHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPY- 201 Query: 188 GSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAA--EFSCPPW--FSAEVKFLIHR 243 G D+W+CGVIL+++L GY PF + D LY++I A +F P W + E K LI++ Sbjct: 202 GKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINK 261 Query: 244 ILDPNPKTRIQIQGIKKDPW 263 +L NP RI K PW Sbjct: 262 MLTINPSKRITAAEALKHPW 281 >2JAM-A nrPDB Length = 304 Score = 181 bits (458), Expect = 8e-46, Method: Compositional matrix adjust. Identities = 99/258 (38%), Positives = 145/258 (56%), Gaps = 13/258 (5%) Query: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYE 76 +G G F++V + TG A+K + KS ++ ++ EI+++K ++H NIV L + Sbjct: 17 LGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRD---SSLENEIAVLKKIKHENIVTLED 73 Query: 77 VLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDLK 136 + S + Y+V++ V+GGELFDRI+ +G E ++ QQ++ AV + H G+ HRDLK Sbjct: 74 IYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHENGIVHRDLK 133 Query: 137 PENLLLDT---NGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSAADI 193 PENLL T N + ++DFGLS + Q G+ + T CGTP YVAPEVL+ + Y A D Sbjct: 134 PENLLYLTPEENSKIMITDFGLSKMEQNGI--MSTACGTPGYVAPEVLAQKPY-SKAVDC 190 Query: 194 WSCGVILFVILAGYLPFSETDLPGLYRKINAA--EFSCPPW--FSAEVKFLIHRILDPNP 249 WS GVI +++L GY PF E L+ KI EF P W S K I +L+ +P Sbjct: 191 WSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAKDFICHLLEKDP 250 Query: 250 KTRIQIQGIKKDPWFRLN 267 R + PW N Sbjct: 251 NERYTCEKALSHPWIDGN 268 >1FOT-A nrPDB Length = 318 Score = 179 bits (455), Expect = 2e-45, Method: Compositional matrix adjust. Identities = 87/261 (33%), Positives = 157/261 (60%), Gaps = 11/261 (4%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 +++ RT+G G+F +V R+ G A+K++ K +++ + V+ E ++ IV HP Sbjct: 8 FQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTHPF 67 Query: 71 IVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGV 130 I+R++ +I+++++++ GGELF + R ++ Y ++ A+ + H K + Sbjct: 68 IIRMWGTFQDAQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLHSKDI 127 Query: 131 YHRDLKPENLLLDTNGNLKVSDFGLSA-LPQEGVELLRTTCGTPNYVAPEVLSGQGYDGS 189 +RDLKPEN+LLD NG++K++DFG + +P ++ T CGTP+Y+APEV+S + Y+ S Sbjct: 128 IYRDLKPENILLDKNGHIKITDFGFAKYVP----DVTYTLCGTPDYIAPEVVSTKPYNKS 183 Query: 190 AADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILDPNP 249 D WS G++++ +LAGY PF +++ Y KI AE PP+F+ +VK L+ R++ + Sbjct: 184 -IDWWSFGILIYEMLAGYTPFYDSNTMKTYEKILNAELRFPPFFNEDVKDLLSRLITRDL 242 Query: 250 KTRI-----QIQGIKKDPWFR 265 R+ + +K PWF+ Sbjct: 243 SQRLGNLQNGTEDVKNHPWFK 263 >2BDW-A nrPDB Length = 362 Score = 179 bits (454), Expect = 2e-45, Method: Compositional matrix adjust. Identities = 102/270 (37%), Positives = 152/270 (56%), Gaps = 10/270 (3%) Query: 1 MTKKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREI 60 M + Y+V +G+G F+ V+ + TG A KI+ + L R +++RE Sbjct: 21 MNASTKFSDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKII-NTKKLSARDFQKLEREA 79 Query: 61 SIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVD 120 I + ++HPNIVRL++ + S Y+V + VTGGELF+ IV + E+++ QQ+++ Sbjct: 80 RICRKLQHPNIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILE 139 Query: 121 AVAHCHCKGVYHRDLKPENLLLDTNGN---LKVSDFGLSALPQEGVELLRTTCGTPNYVA 177 ++A+CH G+ HR+LKPENLLL + +K++DFGL A+ E GTP Y++ Sbjct: 140 SIAYCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGL-AIEVNDSEAWHGFAGTPGYLS 198 Query: 178 PEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAA--EFSCPPW--F 233 PEVL Y DIW+CGVIL+++L GY PF + D LY +I A ++ P W Sbjct: 199 PEVLKKDPY-SKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYDYPSPEWDTV 257 Query: 234 SAEVKFLIHRILDPNPKTRIQIQGIKKDPW 263 + E K LI +L NPK RI K PW Sbjct: 258 TPEAKSLIDSMLTVNPKKRITADQALKVPW 287 >2BRG-A nrPDB Length = 297 Score = 179 bits (453), Expect = 3e-45, Method: Compositional matrix adjust. Identities = 103/265 (38%), Positives = 152/265 (57%), Gaps = 13/265 (4%) Query: 8 VGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVD---QIKREISIMK 64 V +++ +T+GEG + +V+ A N T + VA+KI+ R VD IK+EI I K Sbjct: 6 VEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMK-----RAVDCPENIKKEICINK 60 Query: 65 IVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAH 124 ++ H N+V+ Y + Y+ LE+ +GGELFDRI + E +++++F QL+ V + Sbjct: 61 MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVY 120 Query: 125 CHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEG--VELLRTTCGTPNYVAPEVLS 182 H G+ HRD+KPENLLLD NLK+SDFGL+ + + LL CGT YVAPE+L Sbjct: 121 LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK 180 Query: 183 GQGYDGSAADIWSCGVILFVILAGYLPFSE-TDLPGLYRKINAAEFSCPPW--FSAEVKF 239 + + D+WSCG++L +LAG LP+ + +D Y + PW + Sbjct: 181 RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA 240 Query: 240 LIHRILDPNPKTRIQIQGIKKDPWF 264 L+H+IL NP RI I IKKD W+ Sbjct: 241 LLHKILVENPSARITIPDIKKDRWY 265 >3KK8-A nrPDB Length = 284 Score = 178 bits (452), Expect = 4e-45, Method: Compositional matrix adjust. Identities = 101/260 (38%), Positives = 150/260 (57%), Gaps = 10/260 (3%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 Y+V +G+G F+ V+ + TG A KI+ + L R +++RE I + ++HPN Sbjct: 8 YDVKEELGKGAFSVVRRCVHKTTGLEFAAKII-NTKKLSARDFQKLEREARICRKLQHPN 66 Query: 71 IVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGV 130 IVRL++ + S Y+V + VTGGELF+ IV + E+++ QQ+++++A+CH G+ Sbjct: 67 IVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCHSNGI 126 Query: 131 YHRDLKPENLLLDTNGN---LKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYD 187 HR+LKPENLLL + +K++DFGL A+ E GTP Y++PEVL Y Sbjct: 127 VHRNLKPENLLLASKAKGAAVKLADFGL-AIEVNDSEAWHGFAGTPGYLSPEVLKKDPY- 184 Query: 188 GSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAA--EFSCPPW--FSAEVKFLIHR 243 DIW+CGVIL+++L GY PF + D LY +I A ++ P W + E K LI Sbjct: 185 SKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYDYPSPEWDTVTPEAKSLIDS 244 Query: 244 ILDPNPKTRIQIQGIKKDPW 263 +L NPK RI K PW Sbjct: 245 MLTVNPKKRITADQALKVPW 264 >3SOA-A nrPDB Length = 444 Score = 177 bits (449), Expect = 9e-45, Method: Compositional matrix adjust. Identities = 98/265 (36%), Positives = 152/265 (57%), Gaps = 9/265 (3%) Query: 6 RRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKI 65 R +Y++ +G+G F+ V+ G A I+ + L R +++RE I ++ Sbjct: 8 RFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAMII-NTKKLSARDHQKLEREARICRL 66 Query: 66 VRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHC 125 ++HPNIVRL++ ++ Y++ + VTGGELF+ IV + E+++ QQ+++AV HC Sbjct: 67 LKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHC 126 Query: 126 HCKGVYHRDLKPENLLLDT---NGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLS 182 H GV HR+LKPENLLL + +K++DFGL+ + + GTP Y++PEVL Sbjct: 127 HQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLR 186 Query: 183 GQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAA--EFSCPPW--FSAEVK 238 Y G D+W+CGVIL+++L GY PF + D LY++I A +F P W + E K Sbjct: 187 KDPY-GKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAK 245 Query: 239 FLIHRILDPNPKTRIQIQGIKKDPW 263 LI+++L NP RI K PW Sbjct: 246 DLINKMLTINPSKRITAAEALKHPW 270 >2W4O-A nrPDB Length = 349 Score = 177 bits (449), Expect = 9e-45, Method: Compositional matrix adjust. Identities = 100/263 (38%), Positives = 155/263 (58%), Gaps = 19/263 (7%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQ--IKREISIMKIVRH 68 +EV +G G + V + T A+K++ K+ VD+ ++ EI ++ + H Sbjct: 55 FEVESELGRGATSIVYRCKQKGTQKPYALKVLKKT-------VDKKIVRTEIGVLLRLSH 107 Query: 69 PNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCK 128 PNI++L E+ +P++I +VLE VTGGELFDRIV KG E ++ +Q+++AVA+ H Sbjct: 108 PNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHEN 167 Query: 129 GVYHRDLKPENLLLDT---NGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQG 185 G+ HRDLKPENLL T + LK++DFGLS + + V L++T CGTP Y APE+L G Sbjct: 168 GIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQV-LMKTVCGTPGYCAPEILRGCA 226 Query: 186 YDGSAADIWSCGVILFVILAGYLPF-SETDLPGLYRKI-NAAEFSCPPWF---SAEVKFL 240 Y G D+WS G+I +++L G+ PF E ++R+I N + PW+ S K L Sbjct: 227 Y-GPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDL 285 Query: 241 IHRILDPNPKTRIQIQGIKKDPW 263 + +++ +PK R+ + PW Sbjct: 286 VRKLIVLDPKKRLTTFQALQHPW 308 >4JXF-A nrPDB Length = 266 Score = 173 bits (438), Expect = 2e-43, Method: Compositional matrix adjust. Identities = 86/262 (32%), Positives = 147/262 (56%), Gaps = 2/262 (0%) Query: 7 RVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIV 66 ++ ++VG +G+G+FA V A + TG VAIK++ K + K MV +++ E+ I + Sbjct: 5 KIEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQL 64 Query: 67 RHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGR-LEESESRKYFQQLVDAVAHC 125 +HP+I+ LY + +Y+VLE GE+ + ++ + E+E+R + Q++ + + Sbjct: 65 KHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYL 124 Query: 126 HCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQG 185 H G+ HRDL NLLL N N+K++DFGL+ + E T CGTPNY++PE+ + Sbjct: 125 HSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSA 184 Query: 186 YDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRIL 245 + G +D+WS G + + +L G PF + K+ A++ P + S E K LIH++L Sbjct: 185 H-GLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLL 243 Query: 246 DPNPKTRIQIQGIKKDPWFRLN 267 NP R+ + + P+ N Sbjct: 244 RRNPADRLSLSSVLDHPFMSRN 265 >2V7O-A nrPDB Length = 336 Score = 171 bits (434), Expect = 5e-43, Method: Compositional matrix adjust. Identities = 98/270 (36%), Positives = 149/270 (55%), Gaps = 9/270 (3%) Query: 1 MTKKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREI 60 M R Y++ +G+G F+ V+ A KI+ + L R +++RE Sbjct: 23 MATCTRFTDDYQLFEELGKGAFSVVRRCVKKTPTQEYAAKII-NTKKLSARDHQKLEREA 81 Query: 61 SIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVD 120 I ++++HPNIVRL++ ++ Y+V + VTGGELF+ IV + E+++ Q+++ Sbjct: 82 RICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILE 141 Query: 121 AVAHCHCKGVYHRDLKPENLLLDT---NGNLKVSDFGLSALPQEGVELLRTTCGTPNYVA 177 +V H H + HRDLKPENLLL + +K++DFGL+ Q + GTP Y++ Sbjct: 142 SVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLS 201 Query: 178 PEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAA--EFSCPPW--F 233 PEVL Y G DIW+CGVIL+++L GY PF + D LY++I A +F P W Sbjct: 202 PEVLRKDPY-GKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTV 260 Query: 234 SAEVKFLIHRILDPNPKTRIQIQGIKKDPW 263 + E K LI+++L NP RI K PW Sbjct: 261 TPEAKNLINQMLTINPAKRITADQALKHPW 290 >2YCR-A nrPDB Length = 323 Score = 171 bits (434), Expect = 5e-43, Method: Compositional matrix adjust. Identities = 106/271 (39%), Positives = 153/271 (56%), Gaps = 17/271 (6%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKS--TILKNRMVD---QIKREISIMK 64 +Y + +T+G G +VK A T VAIKI++K I R D ++ EI I+K Sbjct: 11 EYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILK 70 Query: 65 IVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAH 124 + HP I+++ + YIVLE + GGELFD++V RL+E+ + YF Q++ AV + Sbjct: 71 KLNHPCIIKIKNFFDA-EDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQY 129 Query: 125 CHCKGVYHRDLKPENLLLDTNGN---LKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVL 181 H G+ HRDLKPEN+LL + +K++DFG S + E L+RT CGTP Y+APEVL Sbjct: 130 LHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGE-TSLMRTLCGTPTYLAPEVL 188 Query: 182 SGQGYDG--SAADIWSCGVILFVILAGYLPFSETDLP-GLYRKINAAEFSCPPWFSAEVK 238 G G A D WS GVILF+ L+GY PFSE L +I + +++ P AEV Sbjct: 189 VSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVS 248 Query: 239 F----LIHRILDPNPKTRIQIQGIKKDPWFR 265 L+ ++L +PK R + + PW + Sbjct: 249 EKALDLVKKLLVVDPKARFTTEEALRHPWLQ 279 >6CMJ-A nrPDB Length = 321 Score = 170 bits (430), Expect = 1e-42, Method: Compositional matrix adjust. Identities = 98/285 (34%), Positives = 165/285 (57%), Gaps = 16/285 (5%) Query: 7 RVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNR--------MVDQIKR 58 ++ +Y + IG+G++ VK A N + A+K+++K +++ ++Q+ + Sbjct: 32 QLDQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGGCIQPRGPIEQVYQ 91 Query: 59 EISIMKIVRHPNIVRLYEVLASPSK--IYIVLEFVTGGELFDRIVHKGRLEESESRKYFQ 116 EI+I+K + HPN+V+L EVL P++ +Y+V E V G + + K L E ++R YFQ Sbjct: 92 EIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLK-PLSEDQARFYFQ 150 Query: 117 QLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYV 176 L+ + + H + + HRD+KP NLL+ +G++K++DFG+S + LL T GTP ++ Sbjct: 151 DLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFM 210 Query: 177 APEVLSG--QGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKI--NAAEFSCPPW 232 APE LS + + G A D+W+ GV L+ + G PF + + L+ KI A EF P Sbjct: 211 APESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPD 270 Query: 233 FSAEVKFLIHRILDPNPKTRIQIQGIKKDPWF-RLNYVPIRAREE 276 + ++K LI R+LD NP++RI + IK PW R P+ + +E Sbjct: 271 IAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDE 315 >3NCG-A nrPDB Length = 486 Score = 169 bits (428), Expect = 2e-42, Method: Compositional matrix adjust. Identities = 100/326 (30%), Positives = 176/326 (53%), Gaps = 18/326 (5%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 +Y + +G+G+F +V ++ T A+K++ K++ KN+ I RE+ ++K + HP Sbjct: 23 RYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASA-KNKDTSTILREVELLKKLDHP 81 Query: 70 NIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKG 129 NI++L+E+L S YIV E TGGELFD I+ + R E ++ + +Q+ + + H Sbjct: 82 NIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMHKHN 141 Query: 130 VYHRDLKPENLLLDT---NGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGY 186 + HRDLKPEN+LL++ + ++K+ DFGLS Q+ + ++ GT Y+APEVL G Y Sbjct: 142 IVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTK-MKDRIGTAYYIAPEVLRGT-Y 199 Query: 187 DGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAE--FSCPPW--FSAEVKFLIH 242 D D+WS GVIL+++L+G PF + + +++ + F P W S + K LI Sbjct: 200 D-EKCDVWSAGVILYILLSGTPPFYGKNEYDILKRVETGKYAFDLPQWRTISDDAKDLIR 258 Query: 243 RILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEVNLDDIRAVFDGIEGSYVAENVER 302 ++L +P RI + PW I+ E + D+ ++ + + ++ Sbjct: 259 KMLTFHPSLRITATQCLEHPW-------IQKYSSETPTISDLPSLESAMTNIRQFQAEKK 311 Query: 303 NDEGPLMMNAFEMITLSQGLNLSALF 328 + L+ A ++ TL + L+ +F Sbjct: 312 LAQAALLYMASKLTTLDETKQLTEIF 337 >3I6U-A nrPDB Length = 419 Score = 169 bits (427), Expect = 3e-42, Method: Compositional matrix adjust. Identities = 105/271 (38%), Positives = 153/271 (56%), Gaps = 17/271 (6%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKS--TILKNRMVD---QIKREISIMK 64 +Y + +T+G G +VK A T VAI+I++K I R D ++ EI I+K Sbjct: 136 EYIMSKTLGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADPALNVETEIEILK 195 Query: 65 IVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAH 124 + HP I+++ + YIVLE + GGELFD++V RL+E+ + YF Q++ AV + Sbjct: 196 KLNHPCIIKIKNFFDA-EDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQY 254 Query: 125 CHCKGVYHRDLKPENLLLDTNGN---LKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVL 181 H G+ HRDLKPEN+LL + +K++DFG S + E L+RT CGTP Y+APEVL Sbjct: 255 LHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGE-TSLMRTLCGTPTYLAPEVL 313 Query: 182 SGQGYDG--SAADIWSCGVILFVILAGYLPFSETDLP-GLYRKINAAEFSCPPWFSAEVK 238 G G A D WS GVILF+ L+GY PFSE L +I + +++ P AEV Sbjct: 314 VSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVS 373 Query: 239 ----FLIHRILDPNPKTRIQIQGIKKDPWFR 265 L+ ++L +PK R + + PW + Sbjct: 374 EKALDLVKKLLVVDPKARFTTEEALRHPWLQ 404 >3KN6-A nrPDB Length = 325 Score = 169 bits (427), Expect = 3e-42, Method: Compositional matrix adjust. Identities = 100/266 (37%), Positives = 151/266 (56%), Gaps = 22/266 (8%) Query: 15 RTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR-HPNIVR 73 + +GEG+F+ + + + A+KI++K RM ++EI+ +K+ HPNIV+ Sbjct: 17 KPLGEGSFSICRKCVHKKSNQAFAVKIISK------RMEANTQKEITALKLCEGHPNIVK 70 Query: 74 LYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHR 133 L+EV ++V+E + GGELF+RI K E+E+ ++LV AV+H H GV HR Sbjct: 71 LHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHR 130 Query: 134 DLKPENLLL-DTNGNL--KVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSA 190 DLKPENLL D N NL K+ DFG + L + L+T C T +Y APE+L+ GYD S Sbjct: 131 DLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYDES- 189 Query: 191 ADIWSCGVILFVILAGYLPFSETDLP-------GLYRKINAAEFSC--PPW--FSAEVKF 239 D+WS GVIL+ +L+G +PF D + +KI +FS W S E K Sbjct: 190 CDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKD 249 Query: 240 LIHRILDPNPKTRIQIQGIKKDPWFR 265 LI +L +P R+++ G++ + W + Sbjct: 250 LIQGLLTVDPNKRLKMSGLRYNEWLQ 275 >4B6L-A nrPDB Length = 281 Score = 169 bits (427), Expect = 3e-42, Method: Compositional matrix adjust. Identities = 94/262 (35%), Positives = 139/262 (53%), Gaps = 1/262 (0%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 Y GR +G+G FA+ A +T+TG A+K++ +S + K ++I EI + + ++H + Sbjct: 11 YLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRH 70 Query: 71 IVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGV 130 IVR IYI LE + L + L E E R Y +Q++ + + H +G+ Sbjct: 71 IVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGI 130 Query: 131 YHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSA 190 HRDLK N + N LKV DFGL+A + + +T CGTPNYVAPEVL QG+ G Sbjct: 131 LHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGH-GPE 189 Query: 191 ADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILDPNPK 250 AD+WS G +++ +L G PF DL YR I ++ P S + L+ IL +P+ Sbjct: 190 ADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPR 249 Query: 251 TRIQIQGIKKDPWFRLNYVPIR 272 R I I + +F Y P R Sbjct: 250 DRPSIDQILRHDFFTKGYTPDR 271 >5JZN-A nrPDB Length = 280 Score = 167 bits (424), Expect = 6e-42, Method: Compositional matrix adjust. Identities = 100/264 (37%), Positives = 146/264 (55%), Gaps = 16/264 (6%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 +Y+VGRTIG+G FA VK T A+KI+ KS + I+ E+SI++ V+HP Sbjct: 20 RYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHM--IQNEVSILRRVKHP 77 Query: 70 NIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKG 129 NIV L E + P+++Y+V+E V GG+LFD I + E ++ L A+ + H Sbjct: 78 NIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNLASAIKYLHSLN 137 Query: 130 VYHRDLKPENLLL----DTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQG 185 + HRD+KPENLL+ D + +LK+ DFGL+ + L T CGTP YVAPE+++ G Sbjct: 138 IVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGP---LYTVCGTPTYVAPEIIAETG 194 Query: 186 YDGSAADIWSCGVILFVILAGYLPF--SETDLPGLYRKI--NAAEFSCPPW--FSAEVKF 239 Y G DIW+ GVI +++L G+ PF S D L+ +I +F P W S K Sbjct: 195 Y-GLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAKE 253 Query: 240 LIHRILDPNPKTRIQIQGIKKDPW 263 LI +L + R + + PW Sbjct: 254 LITMMLLVDVDQRFSAVQVLEHPW 277 >3DFA-A nrPDB Length = 286 Score = 167 bits (423), Expect = 9e-42, Method: Compositional matrix adjust. Identities = 91/263 (34%), Positives = 152/263 (57%), Gaps = 11/263 (4%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 +Y + +G+G+F +V ++ T A+K++ K++ KN+ I RE+ ++K + HP Sbjct: 23 RYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASA-KNKDTSTILREVELLKKLDHP 81 Query: 70 NIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKG 129 NI++L+E+L S YIV E TGGELFD I+ + R E ++ + +Q+ + + H Sbjct: 82 NIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMHKHN 141 Query: 130 VYHRDLKPENLLLDT---NGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGY 186 + HRDLKPEN+LL++ + ++K+ DFGLS Q+ + ++ GT Y+APEVL G Y Sbjct: 142 IVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTK-MKDRIGTAYYIAPEVLRGT-Y 199 Query: 187 DGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAE--FSCPPW--FSAEVKFLIH 242 D D+WS GVIL+++L+G PF + + +++ + F P W S + K LI Sbjct: 200 D-EKCDVWSAGVILYILLSGTPPFYGKNEYDILKRVETGKYAFDLPQWRTISDDAKDLIR 258 Query: 243 RILDPNPKTRIQIQGIKKDPWFR 265 ++L +P RI + PW + Sbjct: 259 KMLTFHPSLRITATQCLEHPWIQ 281 >4I6B-A nrPDB Length = 308 Score = 167 bits (422), Expect = 1e-41, Method: Compositional matrix adjust. Identities = 89/263 (33%), Positives = 142/263 (53%), Gaps = 1/263 (0%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 +Y G+T+G+G FAK + A KI+ S + K ++I +EI + +I+ H Sbjct: 29 RYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDKEIELHRILHHK 88 Query: 70 NIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKG 129 ++V+ Y IYI+LE+ + + + + L E E R Y +Q+V + + H + Sbjct: 89 HVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQE 148 Query: 130 VYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGS 189 + HRDLK N ++ + LKV DFGL+A + RT CGTPNY++PEVL+ QG+ G+ Sbjct: 149 ILHRDLKLGNFFINESMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGH-GA 207 Query: 190 AADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILDPNP 249 +DIW+ G +++ +L G PF T+L YR I A ++ P A K LI +L NP Sbjct: 208 ESDIWALGCVMYTMLLGRPPFETTNLKETYRSIREARYTMPSSLLAPAKHLIASMLSKNP 267 Query: 250 KTRIQIQGIKKDPWFRLNYVPIR 272 + R + I + +F + P R Sbjct: 268 EDRPSLDDIIRHDFFTQGFTPDR 290 >5JN2-A nrPDB Length = 525 Score = 166 bits (419), Expect = 2e-41, Method: Compositional matrix adjust. Identities = 92/280 (32%), Positives = 156/280 (55%), Gaps = 17/280 (6%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 +Y+ R +G+G+F +V ++ TG A+K+++K + + + + RE+ ++K + HP Sbjct: 68 RYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDHP 127 Query: 70 NIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKG 129 NI++LYE Y+V E TGGELFD I+ + R E ++ + +Q++ + + H Sbjct: 128 NIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNK 187 Query: 130 VYHRDLKPENLLLDT---NGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGY 186 + HRDLKPENLLL++ + N+++ DFGLS E + ++ GT Y+APEVL G Y Sbjct: 188 IVHRDLKPENLLLESKSKDANIRIIDFGLST-HFEASKKMKDKIGTAYYIAPEVLHGT-Y 245 Query: 187 DGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAE--FSCPPW--FSAEVKFLIH 242 D D+WS GVIL+++L+G PF+ + + +K+ + F P W S K LI Sbjct: 246 D-EKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFELPQWKKVSESAKDLIR 304 Query: 243 RILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEVNLD 282 ++L P RI + W I+ +E++++D Sbjct: 305 KMLTYVPSMRISARDALDHEW-------IQTYTKEQISVD 337 >3TXO-A nrPDB Length = 353 Score = 165 bits (418), Expect = 3e-41, Method: Compositional matrix adjust. Identities = 94/281 (33%), Positives = 157/281 (55%), Gaps = 15/281 (5%) Query: 8 VGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR 67 + +E R +G+G+F KV AR +TGD A+K++ K IL++ V+ E I+ + R Sbjct: 22 IDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLAR 81 Query: 68 -HPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCH 126 HP + +L+ +P +++ V+EFV GG+L I R +E+ +R Y +++ A+ H Sbjct: 82 NHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLH 141 Query: 127 CKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTT---CGTPNYVAPEVLSG 183 KG+ +RDLK +N+LLD G+ K++DFG+ +EG+ TT CGTP+Y+APE+L Sbjct: 142 DKGIIYRDLKLDNVLLDHEGHCKLADFGMC---KEGICNGVTTATFCGTPDYIAPEILQE 198 Query: 184 QGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHR 243 Y G A D W+ GV+L+ +L G+ PF + L+ I E P W + ++ Sbjct: 199 MLY-GPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKS 257 Query: 244 ILDPNPKTRIQ--IQG----IKKDPWFR-LNYVPIRAREEE 277 + NP R+ QG I + P+F+ +++ + R+ E Sbjct: 258 FMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIE 298 >3MA6-A nrPDB Length = 298 Score = 164 bits (416), Expect = 5e-41, Method: Compositional matrix adjust. Identities = 89/263 (33%), Positives = 148/263 (56%), Gaps = 10/263 (3%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 +Y+ R +G+G+F +V ++ TG A+K+++K + + + + RE+ ++K + HP Sbjct: 33 RYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDHP 92 Query: 70 NIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKG 129 NI++LYE Y+V E TGGELFD I+ + R E ++ + +Q++ + + H Sbjct: 93 NIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNK 152 Query: 130 VYHRDLKPENLLLDT---NGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGY 186 + HRDLKPENLLL++ + N+++ DFGLS E + ++ GT Y+APEVL G Y Sbjct: 153 IVHRDLKPENLLLESKSKDANIRIIDFGLST-HFEASKKMKDKIGTAYYIAPEVLHGT-Y 210 Query: 187 DGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAE--FSCPPW--FSAEVKFLIH 242 D D+WS GVIL+++L+G PF+ + + +K+ + F P W S K LI Sbjct: 211 D-EKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFELPQWKKVSESAKDLIR 269 Query: 243 RILDPNPKTRIQIQGIKKDPWFR 265 ++L P RI + W + Sbjct: 270 KMLTYVPSMRISARDALDHEWIQ 292 >2Y7J-A nrPDB Length = 365 Score = 164 bits (415), Expect = 6e-41, Method: Compositional matrix adjust. Identities = 100/271 (36%), Positives = 150/271 (55%), Gaps = 18/271 (6%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIM-AKSTILKNRMVDQIK----REISIMK 64 KY+ IG G + V+ + TG A+KIM + L +++++ RE I++ Sbjct: 95 KYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHILR 154 Query: 65 -IVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVA 123 + HP+I+ L + S S +++V + + GELFD + K L E E+R + L++AV+ Sbjct: 155 QVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLEAVS 214 Query: 124 HCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVL-- 181 H + HRDLKPEN+LLD N +++SDFG S + G E LR CGTP Y+APE+L Sbjct: 215 FLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEPG-EKLRELCGTPGYLAPEILKC 273 Query: 182 ----SGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKI--NAAEFSCPPW--F 233 + GY G D+W+CGVILF +LAG PF + R I +FS P W Sbjct: 274 SMDETHPGY-GKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFSSPEWDDR 332 Query: 234 SAEVKFLIHRILDPNPKTRIQIQGIKKDPWF 264 S+ VK LI R+L +P+ R+ + + P+F Sbjct: 333 SSTVKDLISRLLQVDPEARLTAEQALQHPFF 363 >5YV8-A nrPDB Length = 298 Score = 164 bits (415), Expect = 8e-41, Method: Compositional matrix adjust. Identities = 95/286 (33%), Positives = 159/286 (55%), Gaps = 30/286 (10%) Query: 7 RVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNR--------------- 51 ++ +Y + IG+G++ VK A N + A+K+++K +++ Sbjct: 11 QLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAP 70 Query: 52 --------MVDQIKREISIMKIVRHPNIVRLYEVLASPSK--IYIVLEFVTGGELFDRIV 101 ++Q+ +EI+I+K + HPN+V+L EVL P++ +Y+V E V G + + Sbjct: 71 GGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPT 130 Query: 102 HKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQE 161 K L E ++R YFQ L+ + + H + + HRD+KP NLL+ +G++K++DFG+S + Sbjct: 131 LK-PLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKG 189 Query: 162 GVELLRTTCGTPNYVAPEVLSG--QGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLY 219 LL T GTP ++APE LS + + G A D+W+ GV L+ + G PF + + L+ Sbjct: 190 SDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLH 249 Query: 220 RKI--NAAEFSCPPWFSAEVKFLIHRILDPNPKTRIQIQGIKKDPW 263 KI A EF P + ++K LI R+LD NP++RI + IK PW Sbjct: 250 SKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPW 295 >5N23-A nrPDB Length = 352 Score = 164 bits (414), Expect = 1e-40, Method: Compositional matrix adjust. Identities = 91/277 (32%), Positives = 151/277 (54%), Gaps = 9/277 (3%) Query: 7 RVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIV 66 + ++E RT+G G+F +V ++ +TG++ A+KI+ K ++K + ++ E I + V Sbjct: 40 HLDQFERIRTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRIQQAV 99 Query: 67 RHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCH 126 P +V+L S +Y+VLE+ GGE+F + GR E +R Y Q+V + H Sbjct: 100 NFPFLVKLEFSFKDNSNLYMVLEYAPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLH 159 Query: 127 CKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGY 186 + +RDLKPENLL+D G +KV+DFG + + T CGTP Y+APE++ +GY Sbjct: 160 SLDLIYRDLKPENLLIDQQGYIKVADFGFAKRVKGRTPW--TLCGTPEYLAPEIILSKGY 217 Query: 187 DGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILD 246 + A D W+ GV+++ + AGY PF +Y KI + + P FS+++K L+ +L Sbjct: 218 N-KAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQ 276 Query: 247 PNPKTRI-----QIQGIKKDPWF-RLNYVPIRAREEE 277 + R + IK WF +++ I R+ E Sbjct: 277 VDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVE 313 >4AF3-A nrPDB Length = 292 Score = 162 bits (411), Expect = 2e-40, Method: Compositional matrix adjust. Identities = 92/261 (35%), Positives = 140/261 (53%), Gaps = 5/261 (1%) Query: 8 VGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR 67 + +E+GR +G+G F V AR + VA+K++ KS I K + Q++REI I + Sbjct: 22 IDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLH 81 Query: 68 HPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHC 127 HPNI+RLY +IY++LE+ GEL+ + +E + ++L DA+ +CH Sbjct: 82 HPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHG 141 Query: 128 KGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLR-TTCGTPNYVAPEVLSGQGY 186 K V HRD+KPENLLL G LK++DFG S L R T CGT +Y+ PE++ G+ + Sbjct: 142 KKVIHRDIKPENLLLGLKGELKIADFGWSV---HAPSLRRKTMCGTLDYLPPEMIEGRMH 198 Query: 187 DGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILD 246 + D+W GV+ + +L G PF YR+I + P + LI ++L Sbjct: 199 N-EKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPTGAQDLISKLLR 257 Query: 247 PNPKTRIQIQGIKKDPWFRLN 267 NP R+ + + PW R N Sbjct: 258 HNPSERLPLAQVSAHPWVRAN 278 >2YAB-A nrPDB Length = 361 Score = 162 bits (411), Expect = 2e-40, Method: Compositional matrix adjust. Identities = 99/290 (34%), Positives = 159/290 (54%), Gaps = 14/290 (4%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNR---MVDQIKREISIMKIVR 67 Y++G +G G FA VK R TG A K + K +R ++I+RE+SI++ V Sbjct: 14 YDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIEREVSILRQVL 73 Query: 68 HPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHC 127 HPNI+ L++V + + + ++LE V+GGELFD + K L E E+ + +Q++D V + H Sbjct: 74 HPNIITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHT 133 Query: 128 KGVYHRDLKPEN-LLLDTN---GNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSG 183 K + H DLKPEN +LLD N ++K+ DFGL+ ++GVE + GTP +VAPE+++ Sbjct: 134 KKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVE-FKNIFGTPEFVAPEIVNY 192 Query: 184 QGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEV----KF 239 + G AD+WS GVI +++L+G PF I A + F ++ K Sbjct: 193 EPL-GLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAKD 251 Query: 240 LIHRILDPNPKTRIQIQGIKKDPWFR-LNYVPIRAREEEEVNLDDIRAVF 288 I ++L + R+ IQ + PW ++ R E VNL++ + + Sbjct: 252 FIRKLLVKETRKRLTIQEALRHPWITPVDTQQAMVRRESVVNLENFKKQY 301 >3LIJ-A nrPDB Length = 494 Score = 162 bits (410), Expect = 2e-40, Method: Compositional matrix adjust. Identities = 101/325 (31%), Positives = 176/325 (54%), Gaps = 18/325 (5%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 Y+ + +G G + +V R+ T AIKI+ K+++ ++ E++++K++ HPN Sbjct: 39 YQRVKKLGSGAYGEVLLCRDKVTHVERAIKIIRKTSV-STSSNSKLLEEVAVLKLLDHPN 97 Query: 71 IVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGV 130 I++LY+ Y+V+E GGELFD I+H+ + E ++ +Q++ V + H + Sbjct: 98 IMKLYDFFEDKRNYYLVMECYKGGELFDEIIHRMKFNEVDAAVIIKQVLSGVTYLHKHNI 157 Query: 131 YHRDLKPENLLLDT---NGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYD 187 HRDLKPENLLL++ + +K+ DFGLSA+ E + ++ GT Y+APEVL + YD Sbjct: 158 VHRDLKPENLLLESKEKDALIKIVDFGLSAVF-ENQKKMKERLGTAYYIAPEVLR-KKYD 215 Query: 188 GSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAE--FSCPPW--FSAEVKFLIHR 243 D+WS GVILF++LAGY PF + RK+ + F P W S K LI + Sbjct: 216 -EKCDVWSIGVILFILLAGYPPFGGQTDQEILRKVEKGKYTFDSPEWKNVSEGAKDLIKQ 274 Query: 244 ILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEVNLDDIRAVFDGIEGSYVAENVERN 303 +L + + RI Q + PW + + +++E + L ++ + IE +N ++ Sbjct: 275 MLQFDSQRRISAQQALEHPWIK----EMCSKKESGIEL---PSLANAIENMRKFQNSQKL 327 Query: 304 DEGPLMMNAFEMITLSQGLNLSALF 328 + L+ A ++ + + L+ +F Sbjct: 328 AQAALLYMASKLTSQEETKELTDIF 352 >4WB7-A nrPDB Length = 405 Score = 162 bits (410), Expect = 3e-40, Method: Compositional matrix adjust. Identities = 89/276 (32%), Positives = 153/276 (55%), Gaps = 10/276 (3%) Query: 8 VGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR 67 + ++E +T+G G+F +V ++ +TG++ A+KI+ K ++K + ++ E I++ V Sbjct: 95 LDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVN 154 Query: 68 HPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHC 127 P +V+L S +Y+V+E+V GGE+F + GR E +R Y Q+V + H Sbjct: 155 FPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS 214 Query: 128 KGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYD 187 + +RDLKPENLL+D G ++V+DFG + + T CGTP Y+APE++ +GY+ Sbjct: 215 LDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRT---WTLCGTPEYLAPEIILSKGYN 271 Query: 188 GSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILDP 247 A D W+ GV+++ + AGY PF +Y KI + + P FS+++K L+ +L Sbjct: 272 -KAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQV 330 Query: 248 NPKTRI-----QIQGIKKDPWF-RLNYVPIRAREEE 277 + R + IK WF +++ I R+ E Sbjct: 331 DLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVE 366 >3HZT-A nrPDB Length = 467 Score = 162 bits (410), Expect = 3e-40, Method: Compositional matrix adjust. Identities = 90/261 (34%), Positives = 143/261 (54%), Gaps = 10/261 (3%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 +Y+ + +G G + +V ++ TG AIKI+ KS++ + E++++K + HP Sbjct: 5 RYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDHP 64 Query: 70 NIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKG 129 NI++LYE Y+V+E GGELFD I+ + + E ++ +Q++ + H Sbjct: 65 NIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSGTTYLHKHN 124 Query: 130 VYHRDLKPENLLLDTNGN---LKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGY 186 + HRDLKPENLLL++ +K+ DFGLSA + G + ++ GT Y+APEVL + Y Sbjct: 125 IVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGK-MKERLGTAYYIAPEVLR-KKY 182 Query: 187 DGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSC--PPW--FSAEVKFLIH 242 D D+WSCGVIL+++L GY PF + +++ +FS P W S E K L+ Sbjct: 183 D-EKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKGKFSFDPPDWTQVSDEAKQLVK 241 Query: 243 RILDPNPKTRIQIQGIKKDPW 263 +L P RI + PW Sbjct: 242 LMLTYEPSKRISAEEALNHPW 262 >2Z7Q-A nrPDB Length = 321 Score = 162 bits (409), Expect = 3e-40, Method: Compositional matrix adjust. Identities = 89/246 (36%), Positives = 141/246 (57%), Gaps = 5/246 (2%) Query: 11 YEVGRTIGEGTFAKVKFARNT---DTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR 67 +E+ + +G+G+F KV R D+G A+K++ K+T LK R + K E I+ V Sbjct: 30 FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKAT-LKVRDRVRTKMERDILADVN 88 Query: 68 HPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHC 127 HP +V+L+ + K+Y++L+F+ GG+LF R+ + E + + Y +L + H H Sbjct: 89 HPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHS 148 Query: 128 KGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYD 187 G+ +RDLKPEN+LLD G++K++DFGLS + + + CGT Y+APEV++ QG+ Sbjct: 149 LGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHS 208 Query: 188 GSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILDP 247 S AD WS GV++F +L G LPF D I A+ P + S E + L+ + Sbjct: 209 HS-ADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKR 267 Query: 248 NPKTRI 253 NP R+ Sbjct: 268 NPANRL 273 >5XZW-A nrPDB Length = 471 Score = 162 bits (409), Expect = 3e-40, Method: Compositional matrix adjust. Identities = 89/270 (32%), Positives = 143/270 (52%), Gaps = 21/270 (7%) Query: 13 VGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIV 72 + +G+G FA VK A TG A+KI++K ++ N +D + RE+ +++ + HP IV Sbjct: 200 IDEVVGQGAFATVKKAIERTTGKTFAVKIISKRKVIGN--MDGVTRELEVLQKLNHPRIV 257 Query: 73 RLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYH 132 RL Y+V+EFV+GG+L D + G + E R+ +Q++ A+ + H G+ H Sbjct: 258 RLKGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSMGISH 317 Query: 133 RDLKPENLLLDTNGN--LKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYD--- 187 RDLKP+N+L++ + +K++DFGL+ + G ++T CGT YVAPEV+ G+ Sbjct: 318 RDLKPDNILIEQDDPVLVKITDFGLAKVQGNG-SFMKTFCGTLAYVAPEVIRGKDTSVSP 376 Query: 188 ---------GSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPW----FS 234 S D+WS G +++VIL G+LPFS + LY++I + P S Sbjct: 377 DEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRGSYHEGPLKDFRIS 436 Query: 235 AEVKFLIHRILDPNPKTRIQIQGIKKDPWF 264 E + I +L +P R PW Sbjct: 437 EEARDFIDSLLQVDPNNRSTAAKALNHPWI 466 >5X3F-B nrPDB Length = 393 Score = 162 bits (409), Expect = 3e-40, Method: Compositional matrix adjust. Identities = 87/282 (30%), Positives = 156/282 (55%), Gaps = 10/282 (3%) Query: 2 TKKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREIS 61 ++ ++ +++ +T+G G+F +V ++ ++G++ A+KI+ K ++K + ++ E Sbjct: 77 SQNTAQLDQFDRIKTLGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIEHTLNEKR 136 Query: 62 IMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDA 121 I++ V P +V+L S +Y+V+E+V GGE+F + GR E +R Y Q+V Sbjct: 137 ILQAVNFPFLVKLEFSFKDNSNLYMVMEYVAGGEMFSHLRRIGRFSEPHARFYAAQIVLT 196 Query: 122 VAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVL 181 + H + +RDLKPENLL+D G ++V+DFG + + T CGTP Y+APE++ Sbjct: 197 FEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRT---WTLCGTPEYLAPEII 253 Query: 182 SGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLI 241 +GY+ A D W+ GV+++ + AGY PF +Y KI + + P FS+++K L+ Sbjct: 254 LSKGYN-KAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLL 312 Query: 242 HRILDPNPKTRI-----QIQGIKKDPWF-RLNYVPIRAREEE 277 +L + R + IK WF +++ I R+ E Sbjct: 313 RNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVE 354 >4RGJ-A nrPDB Length = 520 Score = 161 bits (408), Expect = 5e-40, Method: Compositional matrix adjust. Identities = 89/265 (33%), Positives = 154/265 (58%), Gaps = 11/265 (4%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 +Y+ + +G+G+F +V +R+ TG AIK+++K + + + + RE+ ++K++ H Sbjct: 61 QYKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKESLLREVELLKMLDHI 120 Query: 70 NIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKG 129 NI++LYE + Y+V + TGGELFD I+ + R E ++ + +Q++ + + H Sbjct: 121 NIMKLYEFFEDNNYYYLVSDVYTGGELFDEIISRKRFYEIDAARIIKQILSGITYMHKNN 180 Query: 130 VYHRDLKPENLLLDTNGN----LKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQG 185 V HRDLKPEN+LL+T +K+ DFGLS E + ++ GT Y+AP+VL G Sbjct: 181 VVHRDLKPENILLETKNKEDMIIKIIDFGLST-HFEYSKKMKDKIGTAYYIAPDVLHGT- 238 Query: 186 YDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCP-PWF---SAEVKFLI 241 YD DIWSCGVIL+++L+G PF+ ++ + +K+ A +++ P F S + K LI Sbjct: 239 YD-EKCDIWSCGVILYILLSGCPPFNGSNEYDILKKVEAGKYTFDLPQFKKISDKAKDLI 297 Query: 242 HRILDPNPKTRIQIQGIKKDPWFRL 266 ++L RI + + W ++ Sbjct: 298 KKMLMYTSAVRISARDALEHEWIKM 322 >3DXN-A nrPDB Length = 287 Score = 161 bits (408), Expect = 5e-40, Method: Compositional matrix adjust. Identities = 90/261 (34%), Positives = 143/261 (54%), Gaps = 10/261 (3%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 +Y+ + +G G + +V ++ TG AIKI+ KS++ + E++++K + HP Sbjct: 22 RYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDHP 81 Query: 70 NIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKG 129 NI++LYE Y+V+E GGELFD I+ + + E ++ +Q++ + H Sbjct: 82 NIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSGTTYLHKHN 141 Query: 130 VYHRDLKPENLLLDTNGN---LKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGY 186 + HRDLKPENLLL++ +K+ DFGLSA + G + ++ GT Y+APEVL + Y Sbjct: 142 IVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGK-MKERLGTAYYIAPEVLR-KKY 199 Query: 187 DGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSC--PPW--FSAEVKFLIH 242 D D+WSCGVIL+++L GY PF + +++ +FS P W S E K L+ Sbjct: 200 D-EKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKGKFSFDPPDWTQVSDEAKQLVK 258 Query: 243 RILDPNPKTRIQIQGIKKDPW 263 +L P RI + PW Sbjct: 259 LMLTYEPSKRISAEEALNHPW 279 >4PDS-A nrPDB Length = 347 Score = 160 bits (405), Expect = 1e-39, Method: Compositional matrix adjust. Identities = 87/273 (31%), Positives = 145/273 (53%), Gaps = 21/273 (7%) Query: 13 VGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIV 72 + +G+G FA VK A TG ++KI++K ++ N +D + RE+ +++ + HP IV Sbjct: 35 IDEVVGQGAFATVKKAIERTTGKTFSVKIISKRKVIGN--MDGVTRELEVLQKLNHPRIV 92 Query: 73 RLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYH 132 RL Y+V+EFV+GG+L D + G + E R+ +Q++ A+ + H G+ H Sbjct: 93 RLKGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSMGISH 152 Query: 133 RDLKPENLLLDTNGN--LKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYD--- 187 RDLKP+N+L++ + +K++ FGL+ + G ++T CGT YVAPEV+ G+ Sbjct: 153 RDLKPDNILIEQDDPVLVKITAFGLAKVQGNG-SFMKTFCGTLAYVAPEVIRGKDTSVSP 211 Query: 188 ---------GSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPW----FS 234 S D+WS G +++VIL G+LPFS + LY++I + P S Sbjct: 212 DEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRGSYHEGPLKDFRIS 271 Query: 235 AEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLN 267 E + I +L +P R PW +++ Sbjct: 272 EEARDFIDSLLQVDPNNRSTAAKALNHPWIKMS 304 >2A27-A nrPDB Length = 321 Score = 159 bits (402), Expect = 2e-39, Method: Compositional matrix adjust. Identities = 98/290 (33%), Positives = 158/290 (54%), Gaps = 14/290 (4%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNR---MVDQIKREISIMKIVR 67 Y++G +G G FA VK R TG A K + K +R ++I+RE+SI++ V Sbjct: 14 YDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVL 73 Query: 68 HPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHC 127 H N++ L++V + + + ++LE V+GGELFD + K L E E+ + +Q++D V + H Sbjct: 74 HHNVITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHT 133 Query: 128 KGVYHRDLKPEN-LLLDTN---GNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSG 183 K + H DLKPEN +LLD N ++K+ DFGL+ ++GVE + GTP +VAPE+++ Sbjct: 134 KKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVE-FKNIFGTPEFVAPEIVNY 192 Query: 184 QGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEV----KF 239 + G AD+WS GVI +++L+G PF I A + F ++ K Sbjct: 193 EPL-GLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAKD 251 Query: 240 LIHRILDPNPKTRIQIQGIKKDPWFR-LNYVPIRAREEEEVNLDDIRAVF 288 I ++L + R+ IQ + PW ++ R E VNL++ R + Sbjct: 252 FIRKLLVKETRKRLTIQEALRHPWITPVDNQQAMVRRESVVNLENFRKQY 301 >4MVF-A nrPDB Length = 506 Score = 159 bits (401), Expect = 3e-39, Method: Compositional matrix adjust. Identities = 99/261 (37%), Positives = 138/261 (52%), Gaps = 13/261 (4%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 KY + +G+GT+ V + T AIK K LKN +++ +EI IMK + HP Sbjct: 58 KYIIDEKLGQGTYGCVYKGIDKVTNQLYAIK-EEKKDRLKN--INRFFQEIEIMKKLDHP 114 Query: 70 NIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKG 129 NIV+LYE + + IY+++E +G ELFD I+ G E + +Q+ A+ + H Sbjct: 115 NIVKLYETYENDNYIYLIMELCSGRELFDSIIENGSFTEKNAATIMKQIFSAIFYLHSLN 174 Query: 130 VYHRDLKPENLLLDTNGN---LKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGY 186 + HRDLKPEN L + LK+ DFGLS G E T GTP YVAP+VL G+ Y Sbjct: 175 IVHRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTG-EFTTTKAGTPYYVAPQVLDGK-Y 232 Query: 187 DGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSC--PPW--FSAEVKFLIH 242 D DIWS GVI++ +L GY PF + +K+ EF W S++ K LI Sbjct: 233 D-KKCDIWSSGVIMYTLLCGYPPFYGDTDNEVLKKVKKGEFCFYENDWGSISSDAKNLIT 291 Query: 243 RILDPNPKTRIQIQGIKKDPW 263 ++L NP R I+ PW Sbjct: 292 KLLTYNPNERCTIEEALNHPW 312 >5D9K-A nrPDB Length = 330 Score = 157 bits (398), Expect = 7e-39, Method: Compositional matrix adjust. Identities = 88/264 (33%), Positives = 153/264 (57%), Gaps = 12/264 (4%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDN---VAIKIMAKSTI-LKNRMVDQIKREISIMKI 65 ++E+ + +G+G+F KV + D A+K++ K+T+ +++R+ +++R+I + Sbjct: 31 QFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVE-- 88 Query: 66 VRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHC 125 V HP IV+L+ + K+Y++L+F+ GG+LF R+ + E + + Y +L A+ H Sbjct: 89 VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHL 148 Query: 126 HCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQG 185 H G+ +RDLKPEN+LLD G++K++DFGLS + + + CGT Y+APEV++ +G Sbjct: 149 HSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRG 208 Query: 186 YDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRIL 245 + S AD WS GV++F +L G LPF D I A+ P + S E + L+ + Sbjct: 209 HTQS-ADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLF 267 Query: 246 DPNPKTRI-----QIQGIKKDPWF 264 NP R+ ++ IK+ +F Sbjct: 268 KRNPANRLGAGPDGVEEIKRHSFF 291 >2J90-A nrPDB Length = 304 Score = 157 bits (398), Expect = 8e-39, Method: Compositional matrix adjust. Identities = 91/266 (34%), Positives = 149/266 (56%), Gaps = 13/266 (4%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNR---MVDQIKREISIMKIVR 67 YE+G +G G FA V+ R TG A K + K + +R ++I+RE++I++ +R Sbjct: 28 YEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILREIR 87 Query: 68 HPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHC 127 HPNI+ L+++ + + + ++LE V+GGELFD + K L E E+ ++ +Q++D V + H Sbjct: 88 HPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDGVHYLHS 147 Query: 128 KGVYHRDLKPEN-LLLDT---NGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSG 183 K + H DLKPEN +LLD N +K+ DFG++ + G E + GTP +VAPE+++ Sbjct: 148 KRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNE-FKNIFGTPEFVAPEIVNY 206 Query: 184 QGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWF----SAEVKF 239 + G AD+WS GVI +++L+G PF I+A + + S K Sbjct: 207 EPL-GLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFSNTSELAKD 265 Query: 240 LIHRILDPNPKTRIQIQGIKKDPWFR 265 I R+L +PK R+ I + W + Sbjct: 266 FIRRLLVKDPKRRMTIAQSLEHSWIK 291 >4L42-A nrPDB Length = 346 Score = 155 bits (393), Expect = 3e-38, Method: Compositional matrix adjust. Identities = 89/277 (32%), Positives = 157/277 (56%), Gaps = 11/277 (3%) Query: 11 YEVGRTIGEGTFAKVKFAR---NTDTGDNVAIKIMAKSTILKN-RMVDQIKREISIMKIV 66 +E+ R +G+G + KV R +TG A+K++ K+ I++N + K E +I++ V Sbjct: 20 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEV 79 Query: 67 RHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCH 126 +HP IV L + K+Y++LE+++GGELF ++ +G E + Y ++ A+ H H Sbjct: 80 KHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLH 139 Query: 127 CKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGY 186 KG+ +RDLKPEN++L+ G++K++DFGL + T CGT Y+APE+L G+ Sbjct: 140 QKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGH 199 Query: 187 DGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILD 246 + A D WS G +++ +L G PF+ + KI + + PP+ + E + L+ ++L Sbjct: 200 N-RAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLK 258 Query: 247 PNPKTRI-----QIQGIKKDPWFR-LNYVPIRAREEE 277 N +R+ ++ P+FR +N+ + AR+ E Sbjct: 259 RNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVE 295 >2JDO-A nrPDB Length = 342 Score = 155 bits (392), Expect = 3e-38, Method: Compositional matrix adjust. Identities = 85/249 (34%), Positives = 134/249 (53%), Gaps = 7/249 (2%) Query: 8 VGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR 67 + ++ + +G+GTF KV R TG A+KI+ K I+ V E +++ R Sbjct: 9 MNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTR 68 Query: 68 HPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHC 127 HP + L + ++ V+E+ GGELF + + E +R Y ++V A+ + H Sbjct: 69 HPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHS 128 Query: 128 KGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVE---LLRTTCGTPNYVAPEVLSGQ 184 + V +RD+K ENL+LD +G++K++DFGL +EG+ ++T CGTP Y+APEVL Sbjct: 129 RDVVYRDIKLENLMLDKDGHIKITDFGLC---KEGISDGATMKTFCGTPEYLAPEVLEDN 185 Query: 185 GYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRI 244 Y G A D W GV+++ ++ G LPF D L+ I E P S E K L+ + Sbjct: 186 DY-GRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGL 244 Query: 245 LDPNPKTRI 253 L +PK R+ Sbjct: 245 LKKDPKQRL 253 >4RLP-A nrPDB Length = 288 Score = 155 bits (392), Expect = 3e-38, Method: Compositional matrix adjust. Identities = 89/277 (32%), Positives = 157/277 (56%), Gaps = 11/277 (3%) Query: 11 YEVGRTIGEGTFAKVKFAR---NTDTGDNVAIKIMAKSTILKN-RMVDQIKREISIMKIV 66 +E+ R +G+G + KV R +TG A+K++ K+ I++N + K E +I++ V Sbjct: 7 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEV 66 Query: 67 RHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCH 126 +HP IV L + K+Y++LE+++GGELF ++ +G E + Y ++ A+ H H Sbjct: 67 KHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLH 126 Query: 127 CKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGY 186 KG+ +RDLKPEN++L+ G++K++DFGL + T CGT Y+APE+L G+ Sbjct: 127 QKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGH 186 Query: 187 DGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILD 246 + A D WS G +++ +L G PF+ + KI + + PP+ + E + L+ ++L Sbjct: 187 N-RAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLK 245 Query: 247 PNPKTRI-----QIQGIKKDPWFR-LNYVPIRAREEE 277 N +R+ ++ P+FR +N+ + AR+ E Sbjct: 246 RNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVE 282 >4YZB-A nrPDB Length = 491 Score = 155 bits (391), Expect = 4e-38, Method: Compositional matrix adjust. Identities = 88/263 (33%), Positives = 149/263 (56%), Gaps = 10/263 (3%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 +Y+ R +G+G+F +V ++ TG A+K+++K + + + + +E+ ++K + HP Sbjct: 31 RYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDKELLLKEVELLKKLDHP 90 Query: 70 NIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKG 129 NI++LYE Y+V E TGGELFD I+ + R E ++ + +Q++ + + H Sbjct: 91 NIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNK 150 Query: 130 VYHRDLKPENLLLDT---NGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGY 186 + HRDLKPENLLL+ + N+++ DFGLS E + ++ GT Y+APEVL G Y Sbjct: 151 IVHRDLKPENLLLENKRKDANIRIIDFGLST-HFESTKKMKDKIGTAYYIAPEVLHGT-Y 208 Query: 187 DGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFS--CPPW--FSAEVKFLIH 242 D D+WS GVIL+++L+G PF+ + + +K+ +F+ P W S K LI Sbjct: 209 D-EKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQWKKVSEPAKDLIR 267 Query: 243 RILDPNPKTRIQIQGIKKDPWFR 265 ++L P RI + + W + Sbjct: 268 KMLAYVPTMRISARDALEHEWLK 290 >3Q5I-A nrPDB Length = 504 Score = 154 bits (390), Expect = 6e-38, Method: Compositional matrix adjust. Identities = 89/281 (31%), Positives = 147/281 (52%), Gaps = 21/281 (7%) Query: 3 KKMRRVGK-YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVD------- 54 KK ++G+ Y R +G G + +V + + AIK++ KS K R D Sbjct: 29 KKEGKIGESYFKVRKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYSDDNKNIEK 88 Query: 55 ---QIKREISIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESES 111 +I EIS++K + HPNI++L++V Y+V EF GGELF++I+++ + +E ++ Sbjct: 89 FHEEIYNEISLLKSLDHPNIIKLFDVFEDKKYFYLVTEFYEGGELFEQIINRHKFDECDA 148 Query: 112 RKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNG---NLKVSDFGLSALPQEGVELLRT 168 +Q++ + + H + HRD+KPEN+LL+ N+K+ DFGLS+ + + LR Sbjct: 149 ANIMKQILSGICYLHKHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSFFSKDYK-LRD 207 Query: 169 TCGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAE-- 226 GT Y+APEVL + D+WSCGVI++++L GY PF + + +K+ + Sbjct: 208 RLGTAYYIAPEVLKKKY--NEKCDVWSCGVIMYILLCGYPPFGGQNDQDIIKKVEKGKYY 265 Query: 227 FSCPPW--FSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFR 265 F W S E K LI +L + R + W + Sbjct: 266 FDFNDWKNISDEAKELIKLMLTYDYNKRCTAEEALNSRWIK 306 >3DB8-A nrPDB Length = 317 Score = 154 bits (390), Expect = 6e-38, Method: Compositional matrix adjust. Identities = 92/269 (34%), Positives = 143/269 (53%), Gaps = 5/269 (1%) Query: 6 RRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKI 65 R + +Y GR +G+G FAK + DT + A K++ KS +LK +++ EI+I K Sbjct: 39 RTMKRYMRGRFLGKGGFAKCYEITDMDTKEVFAGKVVPKSMLLKPHQKEKMSTEIAIHKS 98 Query: 66 VRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGR--LEESESRKYFQQLVDAVA 123 + +P++V + +Y+VLE L + +HK R + E E+R + +Q + V Sbjct: 99 LDNPHVVGFHGFFEDDDFVYVVLEICRRRSLLE--LHKRRKAVTEPEARYFMRQTIQGVQ 156 Query: 124 HCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSG 183 + H V HRDLK NL L+ + ++K+ DFGL+ + E + CGTPNY+APEVL Sbjct: 157 YLHNNRVIHRDLKLGNLFLNDDMDVKIGDFGLATKIEFDGERKKDLCGTPNYIAPEVLCK 216 Query: 184 QGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHR 243 +G+ DIWS G IL+ +L G PF + L Y +I E+S P + LI R Sbjct: 217 KGH-SFEVDIWSLGCILYTLLVGKPPFETSCLKETYIRIKKNEYSVPRHINPVASALIRR 275 Query: 244 ILDPNPKTRIQIQGIKKDPWFRLNYVPIR 272 +L +P R + + D +F Y P+R Sbjct: 276 MLHADPTLRPSVAELLTDEFFTSGYAPMR 304 >1ZWS-A nrPDB Length = 288 Score = 154 bits (389), Expect = 7e-38, Method: Compositional matrix adjust. Identities = 92/264 (34%), Positives = 146/264 (55%), Gaps = 13/264 (4%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNR---MVDQIKREISIMKIVR 67 Y++G +G G FA VK R TG A K + K +R ++I+RE+SI++ V Sbjct: 14 YDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVL 73 Query: 68 HPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHC 127 H N++ L++V + + + ++LE V+GGELFD + K L E E+ + +Q++D V + H Sbjct: 74 HHNVITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHT 133 Query: 128 KGVYHRDLKPEN-LLLDTN---GNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSG 183 K + H DLKPEN +LLD N ++K+ DFGL+ ++GVE + GTP +VAPE+++ Sbjct: 134 KKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVE-FKNIFGTPEFVAPEIVNY 192 Query: 184 QGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWF----SAEVKF 239 + G AD+WS GVI +++L+G PF I + + F S K Sbjct: 193 EPL-GLEADMWSIGVITYILLSGASPFLGDTKQETLANITSVSYDFDEEFFSHTSELAKD 251 Query: 240 LIHRILDPNPKTRIQIQGIKKDPW 263 I ++L + R+ IQ + PW Sbjct: 252 FIRKLLVKETRKRLTIQEALRHPW 275 >3GUB-A nrPDB Length = 295 Score = 154 bits (388), Expect = 9e-38, Method: Compositional matrix adjust. Identities = 93/266 (34%), Positives = 145/266 (54%), Gaps = 13/266 (4%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNR---MVDQIKREISIMKIVR 67 Y+ G +G G FA VK R TG A K + K +R + I+RE+SI+K ++ Sbjct: 13 YDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEIQ 72 Query: 68 HPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHC 127 HPN++ L+EV + + + ++ E V GGELFD + K L E E+ ++ +Q+++ V + H Sbjct: 73 HPNVITLHEVYENKTDVILIGELVAGGELFDFLAEKESLTEEEATEFLKQILNGVYYLHS 132 Query: 128 KGVYHRDLKPEN-LLLDTN---GNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSG 183 + H DLKPEN +LLD N +K+ DFGL+ G E + GTP +VAPE+++ Sbjct: 133 LQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNE-FKNIFGTPEFVAPEIVNY 191 Query: 184 QGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWF----SAEVKF 239 + G AD+WS GVI +++L+G PF ++A + + SA K Sbjct: 192 EPL-GLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFSNTSALAKD 250 Query: 240 LIHRILDPNPKTRIQIQGIKKDPWFR 265 I R+L +PK R+ IQ + PW + Sbjct: 251 FIRRLLVKDPKKRMTIQDSLQHPWIK 276 >5KCV-A nrPDB Length = 460 Score = 151 bits (382), Expect = 5e-37, Method: Compositional matrix adjust. Identities = 86/250 (34%), Positives = 135/250 (54%), Gaps = 8/250 (3%) Query: 8 VGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR 67 + ++E + +G+GTF KV + TG A+KI+ K I+ V E +++ R Sbjct: 161 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSR 220 Query: 68 HPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHC 127 HP + L + ++ V+E+ GGELF + + E +R Y ++V A+ + H Sbjct: 221 HPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHS 280 Query: 128 -KGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVE---LLRTTCGTPNYVAPEVLSG 183 K V +RDLK ENL+LD +G++K++DFGL +EG++ ++T CGTP Y+APEVL Sbjct: 281 EKNVVYRDLKLENLMLDKDGHIKITDFGLC---KEGIKDGATMKTFCGTPEYLAPEVLED 337 Query: 184 QGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHR 243 Y G A D W GV+++ ++ G LPF D L+ I E P E K L+ Sbjct: 338 NDY-GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSG 396 Query: 244 ILDPNPKTRI 253 +L +PK R+ Sbjct: 397 LLKKDPKQRL 406 >3MV5-A nrPDB Length = 342 Score = 151 bits (381), Expect = 7e-37, Method: Compositional matrix adjust. Identities = 86/250 (34%), Positives = 135/250 (54%), Gaps = 8/250 (3%) Query: 8 VGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR 67 + ++E + +G+GTF KV + TG A+KI+ K I+ V E +++ R Sbjct: 9 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSR 68 Query: 68 HPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHC 127 HP + L + ++ V+E+ GGELF + + E +R Y ++V A+ + H Sbjct: 69 HPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHS 128 Query: 128 -KGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVE---LLRTTCGTPNYVAPEVLSG 183 K V +RDLK ENL+LD +G++K++DFGL +EG++ ++T CGTP Y+APEVL Sbjct: 129 EKNVVYRDLKLENLMLDKDGHIKITDFGLC---KEGIKDGATMKTFCGTPEYLAPEVLED 185 Query: 184 QGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHR 243 Y G A D W GV+++ ++ G LPF D L+ I E P E K L+ Sbjct: 186 NDY-GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSG 244 Query: 244 ILDPNPKTRI 253 +L +PK R+ Sbjct: 245 LLKKDPKQRL 254 >6FDY-U nrPDB Length = 276 Score = 150 bits (379), Expect = 1e-36, Method: Compositional matrix adjust. Identities = 97/273 (35%), Positives = 149/273 (54%), Gaps = 15/273 (5%) Query: 7 RVGKYEVGRTIGEGTFAKV-KFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKI 65 R+ + + +G GT+A V K DT + VAIK +AK ++ K V+ + EI I+K Sbjct: 9 RLDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKAS-VENLLTEIEILKG 67 Query: 66 VRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGR-LEESESRKYFQQLVDAVAH 124 +RHP+IV+L + IY+++EF GG+L R +H R L E +R + QQL A+ Sbjct: 68 IRHPHIVQLKDFQWDSDNIYLIMEFCAGGDL-SRFIHTRRILPEKVARVFMQQLASALQF 126 Query: 125 CHCKGVYHRDLKPENLLLDT--NGNLKVSDFGLSAL--PQEGVELLRTTCGTPNYVAPEV 180 H + + H DLKP+N+LL + +LK++DFG + P + +LR G+P Y+APE+ Sbjct: 127 LHERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLR---GSPLYMAPEM 183 Query: 181 LSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINA---AEFSCPPWFSAEV 237 + + YD D+WS GVIL+ L G PF+ L KI + E P S + Sbjct: 184 VCQRQYDAR-VDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPLLSRDC 242 Query: 238 KFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVP 270 + L+ R+L+ +P RI Q PW L ++P Sbjct: 243 RDLLQRLLERDPSRRISFQDFFAHPWVDLEHMP 275 >5DYK-A nrPDB Length = 853 Score = 150 bits (379), Expect = 1e-36, Method: Compositional matrix adjust. Identities = 94/261 (36%), Positives = 138/261 (52%), Gaps = 12/261 (4%) Query: 12 EVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNI 71 E R IG GTF VK + T A+K ++K +I+ + IK E I HP I Sbjct: 542 ETERIIGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLNQQNNIKLEREITAENDHPFI 601 Query: 72 VRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVY 131 +RL Y + E VTGGEL+D I G L +S+++ Y ++ A+ + H + + Sbjct: 602 IRLVRTFKDSKYFYFLTELVTGGELYDAIRKLGLLSKSQAQFYLGSIILAIEYLHERNIV 661 Query: 132 HRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSAA 191 +RDLKPEN+LLD G +K+ DFG + Q T GTP+Y+APEV+ G+GY G Sbjct: 662 YRDLKPENILLDKQGYVKLIDFGCAKKVQGRA---YTLVGTPHYMAPEVILGKGY-GCTV 717 Query: 192 DIWSCGVILFVILAGYLPF--SETDLPGLYRKINAAEFSCPPWFS-AEVKFLIHRILDPN 248 DIW+ G+ L+ + G LPF E D ++R I + + P + + + L+ R+L Sbjct: 718 DIWALGICLYEFICGPLPFGNDEEDQLEIFRDILTGQLTFPDYVTDTDSINLMKRLLCRL 777 Query: 249 PKTRI--QIQG---IKKDPWF 264 P+ RI I G IK P+F Sbjct: 778 PQGRIGCSINGFKDIKDHPFF 798 >5F9E-A nrPDB Length = 353 Score = 149 bits (377), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 84/286 (29%), Positives = 151/286 (52%), Gaps = 4/286 (1%) Query: 7 RVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIV 66 ++ +E+ + +G+G+F KV A T AIK + K +L + V+ E ++ + Sbjct: 17 KIEDFELHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLA 76 Query: 67 -RHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHC 125 HP + ++ + ++ V+E++ GG+L I + + S + Y +++ + Sbjct: 77 WEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFL 136 Query: 126 HCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQG 185 H KG+ +RDLK +N+LLD +G++K++DFG+ G CGTP+Y+APE+L GQ Sbjct: 137 HSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNEFCGTPDYIAPEILLGQK 196 Query: 186 YDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRIL 245 Y+ S D WS GV+L+ +L G PF D L+ I P W E K L+ ++ Sbjct: 197 YNHS-VDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEKEAKDLLVKLF 255 Query: 246 DPNPKTRIQIQG-IKKDPWFR-LNYVPIRAREEEEVNLDDIRAVFD 289 P+ R+ ++G I++ P FR +N+ + +E + +++ FD Sbjct: 256 VREPEKRLGVRGDIRQHPLFREINWEELERKEIDPPFRPKVKSPFD 301 >6BDL-A nrPDB Length = 347 Score = 149 bits (377), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 94/277 (33%), Positives = 147/277 (53%), Gaps = 15/277 (5%) Query: 7 RVGKYEVGRTIGEGTFAKVKFAR-NTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKI 65 ++ + + T+G G F +V+ + ++ A+KI+ K I+ R + I+ E IM+ Sbjct: 32 KLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQG 91 Query: 66 VRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHC 125 IVRLY +Y+++E GGEL+ + +G E+S +R Y +V+A A+ Sbjct: 92 AHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYL 151 Query: 126 HCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQG 185 H KG+ +RDLKPENL+LD G K+ DFG + G + T CGTP YVAPE++ +G Sbjct: 152 HSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTW-TFCGTPEYVAPEIILNKG 210 Query: 186 YDGSAADIWSCGVILFVILAGYLPFSETDLPGLY----RKINAAEFSCPPWFSAEVKFLI 241 +D S AD WS G++++ +L G PFS D Y R I+ EF P + LI Sbjct: 211 HDIS-ADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEF--PKKIAKNAANLI 267 Query: 242 HRILDPNPKTRI-----QIQGIKKDPWFR-LNYVPIR 272 ++ NP R+ ++ I+K WF N+ +R Sbjct: 268 KKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLR 304 >6CCF-A nrPDB Length = 290 Score = 148 bits (374), Expect = 4e-36, Method: Compositional matrix adjust. Identities = 90/286 (31%), Positives = 156/286 (54%), Gaps = 30/286 (10%) Query: 7 RVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIM----------------------AK 44 ++ +Y++ IG+G + V+ A N + A+K++ A+ Sbjct: 3 QLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQ 62 Query: 45 STILKNRM-VDQIKREISIMKIVRHPNIVRLYEVLASPSK--IYIVLEFVTGGELFDRIV 101 K + ++++ +EI+I+K + H N+V+L EVL P++ +Y+V + + G + + Sbjct: 63 GGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEVPC 122 Query: 102 HKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQE 161 K E ++R Y + ++ + + HC+ + HRD+KP NLLL +G++K++DFG+S + Sbjct: 123 DK-PFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEG 181 Query: 162 GVELLRTTCGTPNYVAPEVL--SGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLY 219 L +T GTP ++APE + SGQ + G A D+W+ GV L+ + G PF + + L+ Sbjct: 182 NDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALH 241 Query: 220 RKINAAEFSCP--PWFSAEVKFLIHRILDPNPKTRIQIQGIKKDPW 263 RKI P P S E+K LI ++LD NP+TRI + IK PW Sbjct: 242 RKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPW 287 >4J52-A nrPDB Length = 293 Score = 148 bits (374), Expect = 4e-36, Method: Compositional matrix adjust. Identities = 89/258 (34%), Positives = 136/258 (52%), Gaps = 5/258 (1%) Query: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYE 76 +G+G FAK + DT + A KI+ KS +LK +++ EISI + + H ++V + Sbjct: 22 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 81 Query: 77 VLASPSKIYIVLEFVTGGELFDRIVHKGR--LEESESRKYFQQLVDAVAHCHCKGVYHRD 134 +++VLE L + +HK R L E E+R Y +Q+V + H V HRD Sbjct: 82 FFEDNDFVFVVLELCRRRSLLE--LHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRD 139 Query: 135 LKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSAADIW 194 LK NL L+ + +K+ DFGL+ + E + CGTPNY+APEVLS +G+ D+W Sbjct: 140 LKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGH-SFEVDVW 198 Query: 195 SCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILDPNPKTRIQ 254 S G I++ +L G PF + L Y +I E+S P + LI ++L +P R Sbjct: 199 SIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPT 258 Query: 255 IQGIKKDPWFRLNYVPIR 272 I + D +F Y+P R Sbjct: 259 INELLNDEFFTSGYIPAR 276 >4NIF-A nrPDB Length = 333 Score = 148 bits (373), Expect = 5e-36, Method: Compositional matrix adjust. Identities = 100/304 (32%), Positives = 164/304 (53%), Gaps = 24/304 (7%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 Y V TIG G++++ K + T A+K++ KS K ++I EI +++ +HPN Sbjct: 10 YVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKS---KRDPSEEI--EI-LLRYGQHPN 63 Query: 71 IVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGV 130 I+ L +V +Y+V E + GGEL D+I+ + E E+ + V + H +GV Sbjct: 64 IITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGV 123 Query: 131 YHRDLKPENLL-LDTNGN---LKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGY 186 HRDLKP N+L +D +GN L++ DFG + + LL T C T N+VAPEVL QGY Sbjct: 124 VHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGY 183 Query: 187 DGSAADIWSCGVILFVILAGYLPFSE--TDLP-GLYRKINAAEF--SCPPW--FSAEVKF 239 D DIWS G++L+ +LAGY PF+ +D P + +I + +F S W S K Sbjct: 184 D-EGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKD 242 Query: 240 LIHRILDPNPKTRIQIQGIKKDPWF-RLNYVPIRAREEEEVNLDDIRAVFDGIEGSYVAE 298 L+ ++L +P R+ + + + PW + + +P + +++ D++ V + +Y A Sbjct: 243 LVSKMLHVDPHQRLTAKQVLQHPWVTQKDKLP-----QSQLSHQDLQLVKGAMAATYSAL 297 Query: 299 NVER 302 N + Sbjct: 298 NSSK 301 >3TAC-A nrPDB Length = 361 Score = 147 bits (372), Expect = 7e-36, Method: Compositional matrix adjust. Identities = 91/268 (33%), Positives = 144/268 (53%), Gaps = 15/268 (5%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIM--AKSTILKNRMVDQIKREISIMKIVRH 68 YE+ IG+G F+ V+ N +TG A+KI+ AK T + +KRE SI +++H Sbjct: 28 YELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKH 87 Query: 69 PNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGR----LEESESRKYFQQLVDAVAH 124 P+IV L E +S +Y+V EF+ G +L IV + E+ + Y +Q+++A+ + Sbjct: 88 PHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRY 147 Query: 125 CHCKGVYHRDLKPENLLLDTNGN---LKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVL 181 CH + HRD+KP +LL + N +K+ FG++ E + GTP+++APEV+ Sbjct: 148 CHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFMAPEVV 207 Query: 182 SGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPP--W--FSAEV 237 + Y G D+W CGVILF++L+G LPF T L+ I ++ P W S Sbjct: 208 KREPY-GKPVDVWGCGVILFILLSGCLPFYGTK-ERLFEGIIKGKYKMNPRQWSHISESA 265 Query: 238 KFLIHRILDPNPKTRIQIQGIKKDPWFR 265 K L+ R+L +P RI + PW + Sbjct: 266 KDLVRRMLMLDPAERITVYEALNHPWLK 293 >5FET-A nrPDB Length = 847 Score = 147 bits (372), Expect = 7e-36, Method: Compositional matrix adjust. Identities = 91/253 (35%), Positives = 134/253 (52%), Gaps = 9/253 (3%) Query: 12 EVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNI 71 E R IG GTF VK + T A+K ++K +I+ + IK E I HP I Sbjct: 536 ETERIIGRGTFGTVKLVHHKPTQIRYALKCVSKRSIISLNQQNNIKLEREITAENDHPFI 595 Query: 72 VRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVY 131 +RL + Y + E VTGGEL+D I G L + +++ Y ++ A+ + H + + Sbjct: 596 IRLVRTFKDSNCFYFLTELVTGGELYDAIRKLGLLSKPQAQFYLGSIILAIEYLHERNIV 655 Query: 132 HRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSAA 191 +RDLKPEN+LLD G +K+ DFG + Q T GTP+Y+APEV+ G+GY G Sbjct: 656 YRDLKPENILLDKQGYVKLIDFGCAKKIQGRA---YTLVGTPHYMAPEVILGKGY-GCTV 711 Query: 192 DIWSCGVILFVILAGYLPF--SETDLPGLYRKINAAEFSCPPWFSAEVKF-LIHRILDPN 248 DIW+ GV L+ + G LPF + D ++R I + + P + S + L+ R+L Sbjct: 712 DIWALGVCLYEFICGPLPFGNDQEDQLEIFRDILTGQLTFPDYVSDQDSINLMKRLLCRL 771 Query: 249 PKTRI--QIQGIK 259 P+ RI I G K Sbjct: 772 PQGRIGCSINGFK 784 >2OU7-A nrPDB Length = 335 Score = 147 bits (372), Expect = 7e-36, Method: Compositional matrix adjust. Identities = 89/258 (34%), Positives = 136/258 (52%), Gaps = 5/258 (1%) Query: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYE 76 +G+G FAK + DT + A KI+ KS +LK +++ EISI + + H ++V + Sbjct: 49 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 108 Query: 77 VLASPSKIYIVLEFVTGGELFDRIVHKGR--LEESESRKYFQQLVDAVAHCHCKGVYHRD 134 +++VLE L + +HK R L E E+R Y +Q+V + H V HRD Sbjct: 109 FFEDNDFVFVVLELCRRRSLLE--LHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRD 166 Query: 135 LKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSAADIW 194 LK NL L+ + +K+ DFGL+ + E + CGTPNY+APEVLS +G+ D+W Sbjct: 167 LKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGH-SFEVDVW 225 Query: 195 SCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILDPNPKTRIQ 254 S G I++ +L G PF + L Y +I E+S P + LI ++L +P R Sbjct: 226 SIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPT 285 Query: 255 IQGIKKDPWFRLNYVPIR 272 I + D +F Y+P R Sbjct: 286 INELLNDEFFTSGYIPAR 303 >4JG6-A nrPDB Length = 355 Score = 147 bits (370), Expect = 1e-35, Method: Compositional matrix adjust. Identities = 94/265 (35%), Positives = 144/265 (54%), Gaps = 18/265 (6%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 YEV IG G+++ K + T A+KI+ KS K ++I EI +++ +HPN Sbjct: 37 YEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKS---KRDPTEEI--EI-LLRYGQHPN 90 Query: 71 IVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGV 130 I+ L +V +Y+V E + GGEL D+I+ + E E+ + V + H +GV Sbjct: 91 IITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGV 150 Query: 131 YHRDLKPENLL-LDTNGN---LKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGY 186 HRDLKP N+L +D +GN +++ DFG + + LL T C T N+VAPEVL QGY Sbjct: 151 VHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLERQGY 210 Query: 187 DGSAADIWSCGVILFVILAGYLPFSE--TDLP-GLYRKINAAEFSCPPWF----SAEVKF 239 D +A DIWS GV+L+ +L GY PF+ D P + +I + +FS + S K Sbjct: 211 D-AACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKD 269 Query: 240 LIHRILDPNPKTRIQIQGIKKDPWF 264 L+ ++L +P R+ + + PW Sbjct: 270 LVSKMLHVDPHQRLTAALVLRHPWI 294 >2WTK-C nrPDB Length = 305 Score = 146 bits (368), Expect = 2e-35, Method: Compositional matrix adjust. Identities = 88/276 (31%), Positives = 152/276 (55%), Gaps = 9/276 (3%) Query: 6 RRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVD-QIKREISIMK 64 + +GKY +G +GEG++ KVK +++T A+KI+ K + + + +K+EI +++ Sbjct: 2 KLIGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLR 61 Query: 65 IVRHPNIVRLYEVLAS--PSKIYIVLEFVTGG--ELFDRIVHKGRLEESESRKYFQQLVD 120 +RH N+++L +VL + K+Y+V+E+ G E+ D + K R ++ YF QL+D Sbjct: 62 RLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEK-RFPVCQAHGYFCQLID 120 Query: 121 AVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSAL--PQEGVELLRTTCGTPNYVAP 178 + + H +G+ H+D+KP NLLL T G LK+S G++ P + RT+ G+P + P Sbjct: 121 GLEYLHSQGIVHKDIKPGNLLLTTGGTLKISALGVAEALHPFAADDTCRTSQGSPAFQPP 180 Query: 179 EVLSG-QGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEV 237 E+ +G + G DIWS GV L+ I G PF ++ L+ I ++ P + Sbjct: 181 EIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPL 240 Query: 238 KFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVPIRA 273 L+ +L+ P R I+ I++ WFR + P A Sbjct: 241 SDLLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEA 276 >3ORZ-A nrPDB Length = 316 Score = 145 bits (367), Expect = 3e-35, Method: Compositional matrix adjust. Identities = 83/262 (31%), Positives = 145/262 (55%), Gaps = 9/262 (3%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 ++ G+ +GEG+F+ V AR T AIKI+ K I+K V + RE +M + HP Sbjct: 39 FKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPF 98 Query: 71 IVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGV 130 V+LY K+Y L + GEL I G +E+ +R Y ++V A+ + H KG+ Sbjct: 99 FVKLYFCFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGI 158 Query: 131 YHRDLKPENLLLDTNGNLKVSDFGLSAL--PQEGVELLRTTCGTPNYVAPEVLSGQGYDG 188 HRDLKPEN+LL+ + +++++DFG + + P+ + GT YV+PE+L+ + Sbjct: 159 IHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACK 218 Query: 189 SAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILDPN 248 S +D+W+ G I++ ++AG PF + +++KI E+ P F + + L+ ++L + Sbjct: 219 S-SDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLD 277 Query: 249 PKTRI---QIQG---IKKDPWF 264 R+ +++G +K P+F Sbjct: 278 ATKRLGCEEMEGYGPLKAHPFF 299 >1VZO-A nrPDB Length = 355 Score = 145 bits (365), Expect = 4e-35, Method: Compositional matrix adjust. Identities = 88/267 (32%), Positives = 151/267 (56%), Gaps = 15/267 (5%) Query: 1 MTKKMRRVG--KYEVGRTIGEGTFAKVKFARNT---DTGDNVAIKIMAKSTIL-KNRMVD 54 +T +VG +E+ + +G G + KV R DTG A+K++ K+TI+ K + + Sbjct: 44 LTGHAEKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTE 103 Query: 55 QIKREISIMKIVRH-PNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRK 113 + E +++ +R P +V L+ + +K++++L+++ GGELF + + R E E + Sbjct: 104 HTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQI 163 Query: 114 YFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSA-LPQEGVELLRTTCGT 172 Y ++V A+ H H G+ +RD+K EN+LLD+NG++ ++DFGLS + E CGT Sbjct: 164 YVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYDFCGT 223 Query: 173 PNYVAPEVLSG--QGYDGSAADIWSCGVILFVILAGYLPFS----ETDLPGLYRKINAAE 226 Y+AP+++ G G+D A D WS GV+++ +L G PF+ + + R+I +E Sbjct: 224 IEYMAPDIVRGGDSGHD-KAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSE 282 Query: 227 FSCPPWFSAEVKFLIHRILDPNPKTRI 253 P SA K LI R+L +PK R+ Sbjct: 283 PPYPQEMSALAKDLIQRLLMKDPKKRL 309 >3HDN-A nrPDB Length = 373 Score = 143 bits (360), Expect = 2e-34, Method: Compositional matrix adjust. Identities = 84/248 (33%), Positives = 130/248 (52%), Gaps = 5/248 (2%) Query: 15 RTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIM-KIVRHPNIVR 73 + IG+G+F KV AR+ A+K++ K ILK + I E +++ K V+HP +V Sbjct: 44 KVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVG 103 Query: 74 LYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHR 133 L+ + K+Y VL+++ GGELF + + E +R Y ++ A+ + H + +R Sbjct: 104 LHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYR 163 Query: 134 DLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSAADI 193 DLKPEN+LLD+ G++ ++DFGL E T CGTP Y+APEVL Q YD + D Sbjct: 164 DLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRT-VDW 222 Query: 194 WSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILDPNPKTRI 253 W G +L+ +L G PF + +Y I P + + L+ +L K R Sbjct: 223 WCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQ---KDRT 279 Query: 254 QIQGIKKD 261 + G K D Sbjct: 280 KRLGAKDD 287 >1PHK-A nrPDB Length = 298 Score = 143 bits (360), Expect = 2e-34, Method: Compositional matrix adjust. Identities = 89/271 (32%), Positives = 140/271 (51%), Gaps = 17/271 (6%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIM------AKSTILKNRMVDQIKREISIM- 63 YE +G G + V+ + T A+KI+ + S + + +E+ I+ Sbjct: 19 YEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQELREATLKEVDILR 78 Query: 64 KIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVA 123 K+ HPNI++L + + + ++V + + GELFD + K L E E+RK + L++ + Sbjct: 79 KVSGHPNIIQLKDTYETNTFFFLVFDLMKKGELFDYLTEKVTLSEKETRKIMRALLEVIC 138 Query: 124 HCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSG 183 H + HRDLKPEN+LLD + N+K++DFG S G E LR CGTP+Y+APE++ Sbjct: 139 ALHKLNIVHRDLKPENILLDDDMNIKLTDFGFSCQLDPG-EKLREVCGTPSYLAPEIIEC 197 Query: 184 QGYD-----GSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAA--EFSCPPW--FS 234 D G D+WS GVI++ +LAG PF + R I + +F P W +S Sbjct: 198 SMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFGSPEWDDYS 257 Query: 235 AEVKFLIHRILDPNPKTRIQIQGIKKDPWFR 265 VK L+ R L P+ R + P+F+ Sbjct: 258 DTVKDLVSRFLVVQPQKRYTAEEALAHPFFQ 288 >3A8W-A nrPDB Length = 345 Score = 141 bits (356), Expect = 5e-34, Method: Compositional matrix adjust. Identities = 81/271 (29%), Positives = 147/271 (54%), Gaps = 17/271 (6%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIM-KIVRHP 69 +++ R IG G++AKV R T A+K++ K + + +D ++ E + + HP Sbjct: 11 FDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHP 70 Query: 70 NIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKG 129 +V L+ + S+++ V+E+V GG+L + + +L E +R Y ++ A+ + H +G Sbjct: 71 FLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERG 130 Query: 130 VYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGS 189 + +RDLK +N+LLD+ G++K++D+G+ + T CGTPNY+APE+L G+ Y G Sbjct: 131 IIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDY-GF 189 Query: 190 AADIWSCGVILFVILAGYLPFS---ETDLPG------LYRKINAAEFSCPPWFSAEVKFL 240 + D W+ GV++F ++AG PF +D P L++ I + P S + + Sbjct: 190 SVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASV 249 Query: 241 IHRILDPNPKTRIQIQ------GIKKDPWFR 265 + L+ +PK R+ I+ P+FR Sbjct: 250 LKSFLNKDPKERLGCHPQTGFADIQGHPFFR 280 >6E9W-A nrPDB Length = 443 Score = 141 bits (355), Expect = 6e-34, Method: Compositional matrix adjust. Identities = 86/243 (35%), Positives = 129/243 (53%), Gaps = 9/243 (3%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 YEV + IG G F +V+ R+ T A+K+++K ++K E IM P Sbjct: 104 YEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPW 163 Query: 71 IVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGV 130 +V+L+ +Y+V+E++ GG+L + ++ + E +R Y ++V A+ H G Sbjct: 164 VVQLFYAFQDDRYLYMVMEYMPGGDLVN-LMSNYDVPEKWARFYTAEVVLALDAIHSMGF 222 Query: 131 YHRDLKPENLLLDTNGNLKVSDFGLS-ALPQEGVELLRTTCGTPNYVAPEVL---SGQGY 186 HRD+KP+N+LLD +G+LK++DFG + +EG+ T GTP+Y++PEVL G GY Sbjct: 223 IHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGY 282 Query: 187 DGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKI----NAAEFSCPPWFSAEVKFLIH 242 G D WS GV L+ +L G PF L G Y KI N+ F S E K LI Sbjct: 283 YGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLIC 342 Query: 243 RIL 245 L Sbjct: 343 AFL 345 >4C0T-A nrPDB Length = 974 Score = 141 bits (355), Expect = 6e-34, Method: Compositional matrix adjust. Identities = 82/270 (30%), Positives = 143/270 (52%), Gaps = 11/270 (4%) Query: 6 RRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREI-SIMK 64 R V ++ G+ +GEG+++ V A + TG A+K++ K I+K + V + E ++ + Sbjct: 263 RNVTDFKFGKELGEGSYSTVILATDKITGKQYAVKVLDKRHIIKEKKVKYVNIEKHALNR 322 Query: 65 IVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAH 124 + ++ LY +Y VL++ + GEL I L E +R + Q++DA+ + Sbjct: 323 LSNRLGVISLYFTFQDKDSLYFVLDYASNGELLTLIKRYNTLNEECTRHFGAQILDAIKY 382 Query: 125 CHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVE---------LLRTTCGTPNY 175 H GV HRDLKPEN+LLD ++++DFG + L ++ + ++ GT Y Sbjct: 383 MHDNGVIHRDLKPENILLDDKMRIQITDFGTARLLEKKNDESEEYPVDVRAKSFVGTAEY 442 Query: 176 VAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSA 235 V+PE+L + Y G D+W+ G I++ ++AG PF T+ ++KI +F+ F Sbjct: 443 VSPELLENK-YCGKPGDVWAFGCIIYQMIAGKPPFKATNEYLTFQKITKLQFAFSAGFPT 501 Query: 236 EVKFLIHRILDPNPKTRIQIQGIKKDPWFR 265 ++ LI +IL P R I I+K +F+ Sbjct: 502 IIRDLIKKILVLQPSRRATIPEIQKHYFFQ 531 >4WNO-A nrPDB Length = 287 Score = 140 bits (354), Expect = 8e-34, Method: Compositional matrix adjust. Identities = 88/229 (38%), Positives = 127/229 (55%), Gaps = 19/229 (8%) Query: 8 VGKYEVGRT--IGEGTFAKVKFARNTDTGD-NVAIKIMAKSTILKNRMVDQIKREISIMK 64 VGK+E R IG G FA V R+ D VA+K + K + K++ + + +EI I+K Sbjct: 15 VGKFEFSRKDLIGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQTL--LGKEIKILK 72 Query: 65 IVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAH 124 ++H NIV LY+ + +Y+V+E+ GG+L D + L E R + QQ+ A+ Sbjct: 73 ELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRL 132 Query: 125 CHCKGVYHRDLKPENLLLD------TNGN---LKVSDFGLSALPQEGVELLRTTCGTPNY 175 H KG+ HRDLKP+N+LL N N +K++DFG + Q + + T CG+P Y Sbjct: 133 LHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNM-MAATLCGSPMY 191 Query: 176 VAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPF---SETDLPGLYRK 221 +APEV+ Q YDG AD+WS G I++ L G PF S DL Y K Sbjct: 192 MAPEVIMSQHYDGK-ADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEK 239 >4APC-A nrPDB Length = 350 Score = 139 bits (350), Expect = 2e-33, Method: Compositional matrix adjust. Identities = 78/254 (30%), Positives = 141/254 (55%), Gaps = 9/254 (3%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 KY + IGEG+F K ++T+ G IK + S + ++ ++ +RE++++ ++HP Sbjct: 25 KYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISR-MSSKEREESRREVAVLANMKHP 83 Query: 70 NIVRLYEVLASPSKIYIVLEFVTGGELFDRI-VHKGRL-EESESRKYFQQLVDAVAHCHC 127 NIV+ E +YIV+++ GG+LF RI KG L +E + +F Q+ A+ H H Sbjct: 84 NIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVHD 143 Query: 128 KGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYD 187 + + HRD+K +N+ L +G +++ DFG++ + VEL R GTP Y++PE+ + Y+ Sbjct: 144 RKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARACIGTPYYLSPEICENKPYN 203 Query: 188 GSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPP---WFSAEVKFLIHRI 244 + +DIW+ G +L+ + F + L KI + F PP +S +++ L+ ++ Sbjct: 204 -NKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSF--PPVSLHYSYDLRSLVSQL 260 Query: 245 LDPNPKTRIQIQGI 258 NP+ R + I Sbjct: 261 FKRNPRDRPSVNSI 274 >6QAU-A nrPDB Length = 280 Score = 139 bits (349), Expect = 3e-33, Method: Compositional matrix adjust. Identities = 92/275 (33%), Positives = 144/275 (52%), Gaps = 19/275 (6%) Query: 5 MRRVGKYEVGR--TIGEGTFAKVKFARNTDTGD-NVAIKIMAKSTILKNRMVDQIKREIS 61 M VG +E + +G G FA V R+ D VAIK + K + K++++ + +EI Sbjct: 5 MEVVGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQIL--LGKEIK 62 Query: 62 IMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDA 121 I+K ++H NIV LY+V P+ +++V+E+ GG+L D + KG L E R + Q+ A Sbjct: 63 ILKELQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAA 122 Query: 122 VAHCHCKGVYHRDLKPENLLLD---------TNGNLKVSDFGLSALPQEGVELLRTTCGT 172 + H KG+ HRDLKP+N+LL + +K++DFG + + + CG+ Sbjct: 123 MRILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNM-MAADLCGS 181 Query: 173 PNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPF---SETDLPGLYRKINAAEFSC 229 P Y+APEV+ Q YD + AD+WS G +++ L G PF S DL Y K + S Sbjct: 182 PMYMAPEVIMSQHYD-AKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSI 240 Query: 230 PPWFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWF 264 P S + L+ +L N K R+ + P+ Sbjct: 241 PRETSPYLANLLLGLLQRNQKDRMDFEAFFSHPFL 275 >5LOH-A nrPDB Length = 341 Score = 138 bits (347), Expect = 6e-33, Method: Compositional matrix adjust. Identities = 81/273 (29%), Positives = 144/273 (52%), Gaps = 18/273 (6%) Query: 4 KMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIM 63 K + ++ + + I G F KV + G A+K++ K+ ++ M Q++ E + Sbjct: 31 KPPSIEEFSIVKPISRGAFGKVYLGQKG--GKLYAVKVVKKADMINKNMTHQVQAERDAL 88 Query: 64 KIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVA 123 + + P IV LY L S + +Y+V+E++ GG++ + G +E + KY ++ A+ Sbjct: 89 ALSKSPFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALD 148 Query: 124 HCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALP-QEGVELL-----RTTCGTPNYVA 177 + H G+ HRDLKP+N+L+ G++K++DFGLS + + ++ RT CGTP+Y+A Sbjct: 149 YLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILTTRTFCGTPDYLA 208 Query: 178 PEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEV 237 PE+L G+ + G A D W+ GV LF L G PF++ +++ I + PW E Sbjct: 209 PELLLGRAH-GPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKRDI---PWPEGEE 264 Query: 238 KF------LIHRILDPNPKTRIQIQGIKKDPWF 264 K + +L + R ++ +K+ P F Sbjct: 265 KLSDNAQSAVEILLTIDDTKRAGMKELKRHPLF 297 >4RA4-A nrPDB Length = 355 Score = 137 bits (345), Expect = 9e-33, Method: Compositional matrix adjust. Identities = 73/239 (30%), Positives = 133/239 (55%), Gaps = 2/239 (0%) Query: 16 TIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIV-RHPNIVRL 74 +G+G+F KV A T + AIKI+ K ++++ V+ E ++ ++ + P + +L Sbjct: 27 VLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQL 86 Query: 75 YEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRD 134 + + ++Y V+E+V GG+L I G+ +E ++ Y ++ + H +G+ +RD Sbjct: 87 HSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRD 146 Query: 135 LKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSAADIW 194 LK +N++LD+ G++K++DFG+ RT CGTP+Y+APE+++ Q Y G + D W Sbjct: 147 LKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPY-GKSVDWW 205 Query: 195 SCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILDPNPKTRI 253 + GV+L+ +LAG PF D L++ I S P S E + ++ +P R+ Sbjct: 206 AYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPAKRL 264 >1KOA-A nrPDB Length = 491 Score = 136 bits (342), Expect = 2e-32, Method: Compositional matrix adjust. Identities = 88/297 (29%), Positives = 149/297 (50%), Gaps = 21/297 (7%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIK-IMAKSTILKNRMVDQIKREISIMKIVRHP 69 Y++ +G G F V TG+N A K +M K + +++EI M ++RHP Sbjct: 53 YDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDK----ETVRKEIQTMSVLRHP 108 Query: 70 NIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHK-GRLEESESRKYFQQLVDAVAHCHCK 128 +V L++ +++ ++ EF++GGELF+++ + ++ E E+ +Y +Q+ + H H Sbjct: 109 TLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQVCKGLCHMHEN 168 Query: 129 GVYHRDLKPENLLLDT--NGNLKVSDFGLSAL--PQEGVELLRTTCGTPNYVAPEVLSGQ 184 H DLKPEN++ T + LK+ DFGL+A P++ V + T GT + APEV G+ Sbjct: 169 NYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSV---KVTTGTAEFAAPEVAEGK 225 Query: 185 GYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEF----SCPPWFSAEVKFL 240 G D+WS GV+ +++L+G PF + R + + ++ S S + K Sbjct: 226 PV-GYYTDMWSVGVLSYILLSGLSPFGGENDDETLRNVKSCDWNMDDSAFSGISEDGKDF 284 Query: 241 IHRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEVNLDDIRAVFDGIEGSYVA 297 I ++L +P TR+ I + PW P R + IR D I+ Y A Sbjct: 285 IRKLLLADPNTRMTIHQALEHPWLTPGNAPGRDSQIPSSRYTKIR---DSIKTKYDA 338 >6ED6-A nrPDB Length = 415 Score = 135 bits (340), Expect = 3e-32, Method: Compositional matrix adjust. Identities = 97/313 (30%), Positives = 154/313 (49%), Gaps = 23/313 (7%) Query: 1 MTKKMR----RVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQI 56 + KK+R + Y+V + IG G F +V+ R+ + A+K+++K ++K Sbjct: 76 IVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFF 135 Query: 57 KREISIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQ 116 E IM P +V+L+ +Y+V+E++ GG+L + ++ + E ++ Y Sbjct: 136 WEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVN-LMSNYDVPEKWAKFYTA 194 Query: 117 QLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSA-LPQEGVELLRTTCGTPNY 175 ++V A+ H G+ HRD+KP+N+LLD +G+LK++DFG + + G+ T GTP+Y Sbjct: 195 EVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDY 254 Query: 176 VAPEVLSGQGYD---GSAADIWSCGVILFVILAGYLPFSETDLPGLYRKI----NAAEFS 228 ++PEVL QG D G D WS GV L+ +L G PF L G Y KI N+ F Sbjct: 255 ISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFP 314 Query: 229 CPPWFSAEVKFLIHRILDPNPKTRIQIQGI---------KKDPWFRLNYVPIRAREEEEV 279 S K LI L + + R+ G+ K D W N A E+ Sbjct: 315 EDAEISKHAKNLICAFL-TDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPEL 373 Query: 280 NLDDIRAVFDGIE 292 + D + FD IE Sbjct: 374 SSDIDSSNFDDIE 386 >3UTO-A nrPDB Length = 573 Score = 135 bits (340), Expect = 3e-32, Method: Compositional matrix adjust. Identities = 88/297 (29%), Positives = 149/297 (50%), Gaps = 21/297 (7%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIK-IMAKSTILKNRMVDQIKREISIMKIVRHP 69 Y++ +G G F V TG+N A K +M K + +++EI M ++RHP Sbjct: 159 YDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDK----ETVRKEIQTMSVLRHP 214 Query: 70 NIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHK-GRLEESESRKYFQQLVDAVAHCHCK 128 +V L++ +++ ++ EF++GGELF+++ + ++ E E+ +Y +Q+ + H H Sbjct: 215 TLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQVCKGLCHMHEN 274 Query: 129 GVYHRDLKPENLLLDT--NGNLKVSDFGLSAL--PQEGVELLRTTCGTPNYVAPEVLSGQ 184 H DLKPEN++ T + LK+ DFGL+A P++ V + T GT + APEV G+ Sbjct: 275 NYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSV---KVTTGTAEFAAPEVAEGK 331 Query: 185 GYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEF----SCPPWFSAEVKFL 240 G D+WS GV+ +++L+G PF + R + + ++ S S + K Sbjct: 332 PV-GYYTDMWSVGVLSYILLSGLSPFGGENDDETLRNVKSCDWNMDDSAFSGISEDGKDF 390 Query: 241 IHRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEVNLDDIRAVFDGIEGSYVA 297 I ++L +P TR+ I + PW P R + IR D I+ Y A Sbjct: 391 IRKLLLADPNTRMTIHQALEHPWLTPGNAPGRDSQIPSSRYTKIR---DSIKTKYDA 444 >6BXI-A nrPDB Length = 333 Score = 134 bits (338), Expect = 6e-32, Method: Compositional matrix adjust. Identities = 81/258 (31%), Positives = 129/258 (50%), Gaps = 38/258 (14%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 +E + IG G F +V+ + DTG A+KI+ K+ +L+ V I+ E I+ Sbjct: 8 FESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADSLW 67 Query: 71 IVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGV 130 +V+++ +Y+++EF+ GG++ ++ K L E E++ Y + V A+ H G Sbjct: 68 VVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQLGF 127 Query: 131 YHRDLKPENLLLDTNGNLKVSDFGLS-----------------ALPQEGV---------- 163 HRD+KP+NLLLD+ G++K+SDFGL +LP + Sbjct: 128 IHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSKRKA 187 Query: 164 --------ELLRTTCGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDL 215 +L +T GTP+Y+APEV GY+ D WS GVI++ +L GY PF Sbjct: 188 ETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYN-KLCDWWSLGVIMYEMLIGYPPFCSETP 246 Query: 216 PGLYRKI-NAAE-FSCPP 231 Y+K+ N E + PP Sbjct: 247 QETYKKVMNWKETLTFPP 264 >4FR4-A nrPDB Length = 384 Score = 133 bits (334), Expect = 2e-31, Method: Compositional matrix adjust. Identities = 79/261 (30%), Positives = 139/261 (53%), Gaps = 11/261 (4%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 +E+ R IG+G+F KV + DT A+K M K ++ V + +E+ IM+ + HP Sbjct: 17 FEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQGLEHPF 76 Query: 71 IVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGV 130 +V L+ +++V++ + GG+L + +E + + +LV A+ + + + Sbjct: 77 LVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVMALDYLQNQRI 136 Query: 131 YHRDLKPENLLLDTNGNLKVSDFGLSA-LPQEGVELLRTTCGTPNYVAPEVLS---GQGY 186 HRD+KP+N+LLD +G++ ++DF ++A LP+E + T GT Y+APE+ S G GY Sbjct: 137 IHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQ--ITTMAGTKPYMAPEMFSSRKGAGY 194 Query: 187 DGSAADIWSCGVILFVILAGYLPF---SETDLPGLYRKINAAEFSCPPWFSAEVKFLIHR 243 A D WS GV + +L G P+ S T + + P +S E+ L+ + Sbjct: 195 -SFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTFETTVVTYPSAWSQEMVSLLKK 253 Query: 244 ILDPNPKTRI-QIQGIKKDPW 263 +L+PNP R Q+ ++ P+ Sbjct: 254 LLEPNPDQRFSQLSDVQNFPY 274 >2I0E-A nrPDB Length = 353 Score = 133 bits (334), Expect = 2e-31, Method: Compositional matrix adjust. Identities = 77/270 (28%), Positives = 143/270 (52%), Gaps = 9/270 (3%) Query: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIV-RHPNIVRLY 75 +G+G+F KV + T + A+KI+ K ++++ V+ E ++ + + P + +L+ Sbjct: 28 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 87 Query: 76 EVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDL 135 + ++Y V+E+V GG+L I GR +E + Y ++ + KG+ +RDL Sbjct: 88 SCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDL 147 Query: 136 KPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSAADIWS 195 K +N++LD+ G++K++DFG+ +T CGTP+Y+APE+++ Q Y G + D W+ Sbjct: 148 KLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY-GKSVDWWA 206 Query: 196 CGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILDPNPKTRIQI 255 GV+L+ +LAG PF D L++ I + P S E + ++ +P R+ Sbjct: 207 FGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGC 266 Query: 256 -----QGIKKDPWFRLNYVPIRAREEEEVN 280 + IK+ +FR Y+ E +E+ Sbjct: 267 GPEGERDIKEHAFFR--YIDWEKLERKEIQ 294 >3PFQ-A nrPDB Length = 674 Score = 132 bits (332), Expect = 3e-31, Method: Compositional matrix adjust. Identities = 77/270 (28%), Positives = 143/270 (52%), Gaps = 9/270 (3%) Query: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIV-RHPNIVRLY 75 +G+G+F KV + T + A+KI+ K ++++ V+ E ++ + + P + +L+ Sbjct: 349 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 408 Query: 76 EVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDL 135 + ++Y V+E+V GG+L I GR +E + Y ++ + KG+ +RDL Sbjct: 409 SCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDL 468 Query: 136 KPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSAADIWS 195 K +N++LD+ G++K++DFG+ +T CGTP+Y+APE+++ Q Y G + D W+ Sbjct: 469 KLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY-GKSVDWWA 527 Query: 196 CGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILDPNPKTRIQI 255 GV+L+ +LAG PF D L++ I + P S E + ++ +P R+ Sbjct: 528 FGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGC 587 Query: 256 -----QGIKKDPWFRLNYVPIRAREEEEVN 280 + IK+ +FR Y+ E +E+ Sbjct: 588 GPEGERDIKEHAFFR--YIDWEKLERKEIQ 615 >1NY3-A nrPDB Length = 400 Score = 131 bits (330), Expect = 5e-31, Method: Compositional matrix adjust. Identities = 98/281 (34%), Positives = 141/281 (50%), Gaps = 29/281 (10%) Query: 3 KKMRRVGKYEV-GRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREIS 61 KK + Y+V + +G G KV N T + A+K++ + +RE+ Sbjct: 55 KKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQD--------CPKARREVE 106 Query: 62 I-MKIVRHPNIVRL---YEVLASPSK-IYIVLEFVTGGELFDRIVHKG--RLEESESRKY 114 + + + P+IVR+ YE L + K + IV+E + GGELF RI +G E E+ + Sbjct: 107 LHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEI 166 Query: 115 FQQLVDAVAHCHCKGVYHRDLKPENLLLDT---NGNLKVSDFGLSALPQEGVELLRTTCG 171 + + +A+ + H + HRD+KPENLL + N LK++DFG A L T C Sbjct: 167 MKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGF-AKETTSHNSLTTPCY 225 Query: 172 TPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETD----LPGLYRKINAA-- 225 TP YVAPEVL + YD S D+WS GVI++++L GY PF PG+ +I Sbjct: 226 TPYYVAPEVLGPEKYDKS-CDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQY 284 Query: 226 EFSCPPW--FSAEVKFLIHRILDPNPKTRIQIQGIKKDPWF 264 EF P W S EVK LI +L P R+ I PW Sbjct: 285 EFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 325 >3IS5-A nrPDB Length = 285 Score = 131 bits (330), Expect = 5e-31, Method: Compositional matrix adjust. Identities = 90/265 (33%), Positives = 139/265 (52%), Gaps = 23/265 (8%) Query: 15 RTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRM---VDQIKREISIMKIVRHPNI 71 R +G G F V +G IK TI K+R ++QI+ EI ++K + HPNI Sbjct: 28 RKLGSGAFGDVHLVEERSSGLERVIK-----TINKDRSQVPMEQIEAEIEVLKSLDHPNI 82 Query: 72 VRLYEVLASPSKIYIVLEFVTGGELFDRIVH---KGR-LEESESRKYFQQLVDAVAHCHC 127 ++++EV +YIV+E GGEL +RIV +G+ L E + +Q+++A+A+ H Sbjct: 83 IKIFEVFEDYHNMYIVMETCEGGELLERIVSAQARGKALSEGYVAELMKQMMNALAYFHS 142 Query: 128 KGVYHRDLKPENLLL-DTNGN--LKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQ 184 + V H+DLKPEN+L DT+ + +K+ DFGL+ L + E GT Y+APEV Sbjct: 143 QHVVHKDLKPENILFQDTSPHSPIKIIDFGLAELFKSD-EHSTNAAGTALYMAPEVFKRD 201 Query: 185 GYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAE----FSCPPWFSAEVKFL 240 DIWS GV+++ +L G LPF+ T L + +K E C P V L Sbjct: 202 V--TFKCDIWSAGVVMYFLLTGCLPFTGTSLEEVQQKATYKEPNYAVECRPLTPQAVD-L 258 Query: 241 IHRILDPNPKTRIQIQGIKKDPWFR 265 + ++L +P+ R + WF+ Sbjct: 259 LKQMLTKDPERRPSAAQVLHHEWFK 283 >2OZA-A nrPDB Length = 356 Score = 131 bits (330), Expect = 6e-31, Method: Compositional matrix adjust. Identities = 100/277 (36%), Positives = 138/277 (49%), Gaps = 21/277 (7%) Query: 3 KKMRRVGKYEV-GRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREIS 61 KK + Y+V + +G G KV N T + A+K++ + R V+ R Sbjct: 11 KKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKAR-REVELHWRASQ 69 Query: 62 IMKIVRHPNIVRLYEVLASPSK-IYIVLEFVTGGELFDRIVHKG--RLEESESRKYFQQL 118 IVR IV +YE L + K + IV+E + GGELF RI +G E E+ + + + Sbjct: 70 CPHIVR---IVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSI 126 Query: 119 VDAVAHCHCKGVYHRDLKPENLLLDT---NGNLKVSDFGLSALPQEGVELLRTTCGTPNY 175 +A+ + H + HRD+KPENLL + N LK++DFG A L T C TP Y Sbjct: 127 GEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGF-AKETTSHNSLTTPCYTPYY 185 Query: 176 VAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETD----LPGLYRKINAA--EFSC 229 VAPEVL + YD S D+WS GVI++++L GY PF PG+ +I EF Sbjct: 186 VAPEVLGPEKYDKS-CDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPN 244 Query: 230 PPW--FSAEVKFLIHRILDPNPKTRIQIQGIKKDPWF 264 P W S EVK LI +L P R+ I PW Sbjct: 245 PEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 281 >4X7Q-B nrPDB Length = 312 Score = 130 bits (327), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 87/265 (32%), Positives = 134/265 (50%), Gaps = 17/265 (6%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILK-NRMVDQIKREISIMKIVR- 67 +Y +G +G+G F V VAIK++ ++ +L + + D + + + + + Sbjct: 32 EYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKV 91 Query: 68 -----HPNIVRLYEVLASPSKIYIVLE-FVTGGELFDRIVHKGRLEESESRKYFQQLVDA 121 HP ++RL + + +VLE + +LFD I KG L E SR +F Q+V A Sbjct: 92 GAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAA 151 Query: 122 VAHCHCKGVYHRDLKPENLLLDT-NGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEV 180 + HCH +GV HRD+K EN+L+D G K+ DFG AL + E GT Y PE Sbjct: 152 IQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHD--EPYTDFDGTRVYSPPEW 209 Query: 181 LSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFL 240 +S Y A +WS G++L+ ++ G +PF E D ++I AE P S + L Sbjct: 210 ISRHQYHALPATVWSLGILLYDMVCGDIPF-ERD-----QEILEAELHFPAHVSPDCCAL 263 Query: 241 IHRILDPNPKTRIQIQGIKKDPWFR 265 I R L P P +R ++ I DPW + Sbjct: 264 IRRCLAPKPSSRPSLEEILLDPWMQ 288 >3DLS-A nrPDB Length = 335 Score = 129 bits (325), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 83/261 (31%), Positives = 136/261 (52%), Gaps = 15/261 (5%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVD-----QIKREISIMK 64 KY +G G F V A + + V +K + K +L++ ++ ++ EI+I+ Sbjct: 25 KYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILS 84 Query: 65 IVRHPNIVRLYEVLASPSKIYIVLE-FVTGGELFDRIVHKGRLEESESRKYFQQLVDAVA 123 V H NI+++ ++ + +V+E +G +LF I RL+E + F+QLV AV Sbjct: 85 RVEHANIIKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYIFRQLVSAVG 144 Query: 124 HCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSG 183 + K + HRD+K EN+++ + +K+ DFG +A + G +L T CGT Y APEVL G Sbjct: 145 YLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERG-KLFYTFCGTIEYCAPEVLMG 203 Query: 184 QGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWF-SAEVKFLIH 242 Y G ++WS GV L+ ++ PF E L + AA PP+ S E+ L+ Sbjct: 204 NPYRGPELEMWSLGVTLYTLVFEENPFCE-----LEETVEAAIH--PPYLVSKELMSLVS 256 Query: 243 RILDPNPKTRIQIQGIKKDPW 263 +L P P+ R ++ + DPW Sbjct: 257 GLLQPVPERRTTLEKLVTDPW 277 >2X4F-A nrPDB Length = 373 Score = 129 bits (324), Expect = 3e-30, Method: Compositional matrix adjust. Identities = 91/281 (32%), Positives = 146/281 (51%), Gaps = 18/281 (6%) Query: 11 YEVGRT--IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 Y V +T +G G F +V T TG +A KI+ K+ +K++ +++K EIS+M + H Sbjct: 89 YTVSKTEILGGGRFGQVHKCEETATGLKLAAKII-KTRGMKDK--EEVKNEISVMNQLDH 145 Query: 69 PNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKG-RLEESESRKYFQQLVDAVAHCHC 127 N+++LY+ S + I +V+E+V GGELFDRI+ + L E ++ + +Q+ + + H H Sbjct: 146 ANLIQLYDAFESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQ 205 Query: 128 KGVYHRDLKPENLLLDTNG--NLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQG 185 + H DLKPEN+L +K+ DFGL A + E L+ GTP ++APEV++ Sbjct: 206 MYILHLDLKPENILCVNRDAKQIKIIDFGL-ARRYKPREKLKVNFGTPEFLAPEVVN--- 261 Query: 186 YD--GSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPW----FSAEVKF 239 YD D+WS GVI +++L+G PF + I A + S E K Sbjct: 262 YDFVSFPTDMWSVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEFQDISEEAKE 321 Query: 240 LIHRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEVN 280 I ++L RI K PW + + R +++ N Sbjct: 322 FISKLLIKEKSWRISASEALKHPWLSDHKLHSRLSAQKKKN 362 >3KA0-A nrPDB Length = 320 Score = 129 bits (323), Expect = 3e-30, Method: Compositional matrix adjust. Identities = 99/277 (35%), Positives = 137/277 (49%), Gaps = 21/277 (7%) Query: 3 KKMRRVGKYEV-GRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREIS 61 KK + Y+V + +G G KV N T + A+K++ + R V+ R Sbjct: 9 KKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKAR-REVELHWRASQ 67 Query: 62 IMKIVRHPNIVRLYEVLASPSK-IYIVLEFVTGGELFDRIVHKG--RLEESESRKYFQQL 118 IVR IV +YE L + K + IV+E + GGELF RI +G E E+ + + + Sbjct: 68 CPHIVR---IVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSI 124 Query: 119 VDAVAHCHCKGVYHRDLKPENLLLDT---NGNLKVSDFGLSALPQEGVELLRTTCGTPNY 175 +A+ + H + HRD+KPENLL + N LK++DFG A L C TP Y Sbjct: 125 GEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGF-AKETTSHNSLTEPCYTPYY 183 Query: 176 VAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETD----LPGLYRKINAA--EFSC 229 VAPEVL + YD S D+WS GVI++++L GY PF PG+ +I EF Sbjct: 184 VAPEVLGPEKYDKS-CDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPN 242 Query: 230 PPW--FSAEVKFLIHRILDPNPKTRIQIQGIKKDPWF 264 P W S EVK LI +L P R+ I PW Sbjct: 243 PEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 279 >1KOB-A nrPDB Length = 387 Score = 125 bits (315), Expect = 3e-29, Method: Compositional matrix adjust. Identities = 81/274 (29%), Positives = 137/274 (50%), Gaps = 18/274 (6%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 Y++ +G G F V TG K + L V K EISIM + HP Sbjct: 53 YDILEELGSGAFGVVHRCVEKATGRVFVAKFINTPYPLDKYTV---KNEISIMNQLHHPK 109 Query: 71 IVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKG-RLEESESRKYFQQLVDAVAHCHCKG 129 ++ L++ ++ ++LEF++GGELFDRI + ++ E+E Y +Q + + H H Sbjct: 110 LINLHDAFEDKYEMVLILEFLSGGELFDRIAAEDYKMSEAEVINYMRQACEGLKHMHEHS 169 Query: 130 VYHRDLKPENLLLDTN--GNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYD 187 + H D+KPEN++ +T ++K+ DFGL A E+++ T T + APE++ + Sbjct: 170 IVHLDIKPENIMCETKKASSVKIIDFGL-ATKLNPDEIVKVTTATAEFAAPEIVDREPV- 227 Query: 188 GSAADIWSCGVILFVILAGYLPFS-ETDLPGLYR------KINAAEFSCPPWFSAEVKFL 240 G D+W+ GV+ +V+L+G PF+ E DL L + + FS S E K Sbjct: 228 GFYTDMWAIGVLGYVLLSGLSPFAGEDDLETLQNVKRCDWEFDEDAFSS---VSPEAKDF 284 Query: 241 IHRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAR 274 I +L P+ R+ + + PW + ++ + +R Sbjct: 285 IKNLLQKEPRKRLTVHDALEHPWLKGDHSNLTSR 318 >2XNP-A nrPDB Length = 279 Score = 123 bits (309), Expect = 1e-28, Method: Compositional matrix adjust. Identities = 84/273 (30%), Positives = 140/273 (51%), Gaps = 24/273 (8%) Query: 7 RVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKR----EISI 62 R YEV TIG G++ + + R G KI+ + M + K+ E+++ Sbjct: 4 RAEDYEVLYTIGTGSYGRCQKIRRKSDG-----KILVWKELDYGSMTEAEKQMLVSEVNL 58 Query: 63 MKIVRHPNIVRLYE--VLASPSKIYIVLEFVTGGELFDRIVHKGR-----LEESESRKYF 115 ++ ++HPNIVR Y+ + + + +YIV+E+ GG+L ++ KG L+E + Sbjct: 59 LRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLAS-VITKGTKERQYLDEEFVLRVM 117 Query: 116 QQLVDAVAHCHCKG-----VYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTC 170 QL A+ CH + V HRDLKP N+ LD N+K+ DFGL+ + +T Sbjct: 118 TQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFV 177 Query: 171 GTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCP 230 GTP Y++PE ++ Y+ +DIWS G +L+ + A PF+ L KI +F Sbjct: 178 GTPYYMSPEQMNRMSYN-EKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRI 236 Query: 231 PW-FSAEVKFLIHRILDPNPKTRIQIQGIKKDP 262 P+ +S E+ +I R+L+ R ++ I ++P Sbjct: 237 PYRYSDELNEIITRMLNLKDYHRPSVEEILENP 269 >4KS7-A nrPDB Length = 292 Score = 123 bits (309), Expect = 1e-28, Method: Compositional matrix adjust. Identities = 80/261 (30%), Positives = 142/261 (54%), Gaps = 16/261 (6%) Query: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYE 76 IGEG+ V AR +G VA+K+M + K + + + E+ IM+ +H N+V +Y+ Sbjct: 31 IGEGSTGIVCLAREKHSGRQVAVKMM---DLRKQQRRELLFNEVVIMRDYQHFNVVEMYK 87 Query: 77 VLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDLK 136 ++++++EF+ GG L D IV + RL E + + ++ A+A+ H +GV HRD+K Sbjct: 88 SYLVGEELWVLMEFLQGGALTD-IVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIK 146 Query: 137 PENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSAADIWSC 196 +++LL +G +K+SDFG A + V ++ GTP ++APEV+S Y + DIWS Sbjct: 147 SDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLY-ATEVDIWSL 205 Query: 197 GVILFVILAGYLP-FSETDLPGLYRKINAAEFSCPPWF------SAEVKFLIHRILDPNP 249 G+++ ++ G P FS++ + + R + S PP S ++ + R+L +P Sbjct: 206 GIMVIEMVDGEPPYFSDSPVQAMKRLRD----SPPPKLKNSHKVSPVLRDFLERMLVRDP 261 Query: 250 KTRIQIQGIKKDPWFRLNYVP 270 + R Q + P+ +P Sbjct: 262 QERATAQELLDHPFLLQTGLP 282 >4BBM-A nrPDB Length = 331 Score = 123 bits (308), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 75/213 (35%), Positives = 113/213 (53%), Gaps = 4/213 (1%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIK-REISIMKIVRH 68 KYE +GEG++ V RN DTG VAIK +S ++MV +I REI ++K +RH Sbjct: 26 KYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESD--DDKMVKKIAMREIKLLKQLRH 83 Query: 69 PNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCK 128 N+V L EV + Y+V EFV L D + L+ +KY Q+++ + CH Sbjct: 84 ENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIGFCHSH 143 Query: 129 GVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDG 188 + HRD+KPEN+L+ +G +K+ DFG + E+ T Y APE+L G G Sbjct: 144 NIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYDDEVATRWYRAPELLVGDVKYG 203 Query: 189 SAADIWSCGVILFVILAGYLPF-SETDLPGLYR 220 A D+W+ G ++ + G F ++D+ LY Sbjct: 204 KAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYH 236 >2WQN-A nrPDB Length = 310 Score = 122 bits (307), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 76/258 (29%), Positives = 130/258 (50%), Gaps = 13/258 (5%) Query: 8 VGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR 67 + + + + IG G F++V A G VA+K + ++ + +EI ++K + Sbjct: 31 LANFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLN 90 Query: 68 HPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVH----KGRLEESESRKYFQQLVDAVA 123 HPN+++ Y +++ IVLE G+L I H K + E KYF QL A+ Sbjct: 91 HPNVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALE 150 Query: 124 HCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSG 183 H H + V HRD+KP N+ + G +K+ D GL + GTP Y++PE + Sbjct: 151 HMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHE 210 Query: 184 QGYDGSAADIWSCGVILFVILAGYLPF--SETDLPGLYRKINAAEFSCPPW----FSAEV 237 GY+ +DIWS G +L+ + A PF + +L L +KI ++ PP +S E+ Sbjct: 211 NGYNFK-SDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDY--PPLPSDHYSEEL 267 Query: 238 KFLIHRILDPNPKTRIQI 255 + L++ ++P+P+ R + Sbjct: 268 RQLVNMCINPDPEKRPDV 285 >3FXW-A nrPDB Length = 336 Score = 122 bits (305), Expect = 4e-28, Method: Compositional matrix adjust. Identities = 94/305 (30%), Positives = 151/305 (49%), Gaps = 29/305 (9%) Query: 3 KKMRRVGKYEVGRTI-GEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREIS 61 KK Y++ + + G G KV + TG A+K++ S + VD + Sbjct: 22 KKYAVTDDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLLYDSPKARQE-VDHHWQASG 80 Query: 62 IMKIVRHPNIVRLYEVLASPSK-IYIVLEFVTGGELFDRIVHKG--RLEESESRKYFQQL 118 IV I+ +YE + + + I++E + GGELF RI +G E E+ + + + Sbjct: 81 GPHIV---CILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDI 137 Query: 119 VDAVAHCHCKGVYHRDLKPENLLL---DTNGNLKVSDFGLSALPQEGVELLRTTCGTPNY 175 A+ H + HRD+KPENLL + + LK++DFG + + L+T C TP Y Sbjct: 138 GTAIQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNA--LQTPCYTPYY 195 Query: 176 VAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPF----SETDLPGLYRKINAAE--FSC 229 VAPEVL + YD S D+WS GVI++++L G+ PF + PG+ R+I + F Sbjct: 196 VAPEVLGPEKYDKS-CDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQYGFPN 254 Query: 230 PPW--FSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYV----PI---RAREEEEVN 280 P W S + K LI +L +P R+ I PW + V P+ R +E++ + Sbjct: 255 PEWSEVSEDAKQLIRLLLKTDPTERLTITQFMNHPWINQSMVVPQTPLHTARVLQEDKDH 314 Query: 281 LDDIR 285 D+++ Sbjct: 315 WDEVK 319 >5UUU-A nrPDB Length = 547 Score = 120 bits (300), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 84/270 (31%), Positives = 135/270 (50%), Gaps = 15/270 (5%) Query: 8 VGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTI-LKNRMVDQIKREI--SIMK 64 + + V R IG G F +V R DTG A+K + K I +K + I S++ Sbjct: 197 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 256 Query: 65 IVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAH 124 P IV + +P K+ +L+ + GG+L + G E++ R Y +++ + H Sbjct: 257 TGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEH 316 Query: 125 CHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLS-G 183 H + V +RDLKP N+LLD +G++++SD GL+ + + GT Y+APEVL G Sbjct: 317 MHNRFVVYRDLKPANILLDEHGHVRISDLGLAC--DFSKKKPHASVGTHGYMAPEVLQKG 374 Query: 184 QGYDGSAADIWSCGVILFVILAGYLPFSE---TDLPGLYRKINAAEFSCPPWFSAEVKFL 240 YD S+AD +S G +LF +L G+ PF + D + R P FS E++ L Sbjct: 375 VAYD-SSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSL 433 Query: 241 IHRILDPNPKTRIQIQG-----IKKDPWFR 265 + +L + R+ G +K+ P+FR Sbjct: 434 LEGLLQRDVNRRLGCLGRGAQEVKESPFFR 463 >3PVW-A nrPDB Length = 695 Score = 120 bits (300), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 84/270 (31%), Positives = 135/270 (50%), Gaps = 15/270 (5%) Query: 8 VGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTI-LKNRMVDQIKREI--SIMK 64 + + V R IG G F +V R DTG A+K + K I +K + I S++ Sbjct: 188 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 247 Query: 65 IVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAH 124 P IV + +P K+ +L+ + GG+L + G E++ R Y +++ + H Sbjct: 248 TGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEH 307 Query: 125 CHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLS-G 183 H + V +RDLKP N+LLD +G++++SD GL+ + + GT Y+APEVL G Sbjct: 308 MHNRFVVYRDLKPANILLDEHGHVRISDLGLAC--DFSKKKPHASVGTHGYMAPEVLQKG 365 Query: 184 QGYDGSAADIWSCGVILFVILAGYLPFSE---TDLPGLYRKINAAEFSCPPWFSAEVKFL 240 YD S+AD +S G +LF +L G+ PF + D + R P FS E++ L Sbjct: 366 VAYD-SSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSL 424 Query: 241 IHRILDPNPKTRIQIQG-----IKKDPWFR 265 + +L + R+ G +K+ P+FR Sbjct: 425 LEGLLQRDVNRRLGCLGRGAQEVKESPFFR 454 >3HKO-A nrPDB Length = 345 Score = 119 bits (297), Expect = 4e-27, Method: Compositional matrix adjust. Identities = 98/308 (31%), Positives = 145/308 (47%), Gaps = 55/308 (17%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTI--LKNRMVDQIKREISIMKIVR 67 KY + IG+G++ V+ A T AIKIM K+ I + + V++IK E+ +MK + Sbjct: 27 KYHLKGAIGQGSYGVVRVAIENQTRAIRAIKIMNKNKIRQINPKDVERIKTEVRLMKKLH 86 Query: 68 HPNIVRLYEVLASPSKIYIVLEFVTGGELFDRI--------------VHKGRL------- 106 HPNI RLYEV I +V+E GG L D++ V K ++ Sbjct: 87 HPNIARLYEVYEDEQYICLVMELCHGGHLLDKLNVFIDDSTGKCAMDVVKTQICPCPECN 146 Query: 107 EES---------ESRKYFQ----------QLVDAVAHCHCKGVYHRDLKPENLLLDTNGN 147 EE+ ES + Q Q+ A+ + H +G+ HRD+KPEN L TN + Sbjct: 147 EEAINGSIHGFRESLDFVQREKLISNIMRQIFSALHYLHNQGICHRDIKPENFLFSTNKS 206 Query: 148 --LKVSDFGLS----ALPQEGVELLRTTCGTPNYVAPEVL--SGQGYDGSAADIWSCGVI 199 +K+ DFGLS L + T GTP +VAPEVL + + Y G D WS GV+ Sbjct: 207 FEIKLVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEVLNTTNESY-GPKCDAWSAGVL 265 Query: 200 LFVILAGYLPF-SETDLPGLYRKINAA-EFSCPPW--FSAEVKFLIHRILDPNPKTRIQI 255 L ++L G +PF D + + +N F P + S + L+ +L+ N R Sbjct: 266 LHLLLMGAVPFPGVNDADTISQVLNKKLCFENPNYNVLSPLARDLLSNLLNRNVDERFDA 325 Query: 256 QGIKKDPW 263 + PW Sbjct: 326 MRALQHPW 333 >2F57-A nrPDB Length = 317 Score = 119 bits (297), Expect = 4e-27, Method: Compositional matrix adjust. Identities = 80/261 (30%), Positives = 136/261 (52%), Gaps = 16/261 (6%) Query: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYE 76 IGEG+ V A TG VA+K K + K + + + E+ IM+ H N+V +Y Sbjct: 53 IGEGSTGIVCIATEKHTGKQVAVK---KMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYS 109 Query: 77 VLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDLK 136 ++++V+EF+ GG L D + H R+ E + ++ A+++ H +GV HRD+K Sbjct: 110 SYLVGDELWVVMEFLEGGALTDIVTHT-RMNEEQIATVCLSVLRALSYLHNQGVIHRDIK 168 Query: 137 PENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSAADIWSC 196 +++LL ++G +K+SDFG A + V ++ GTP ++APEV+S Y G+ DIWS Sbjct: 169 SDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPY-GTEVDIWSL 227 Query: 197 GVILFVILAGYLP-FSETDLPGLYRKINAAEFSCPPW------FSAEVKFLIHRILDPNP 249 G+++ ++ G P F+E L + R + S PP S+ ++ + +L P Sbjct: 228 GIMVIEMIDGEPPYFNEPPLQAMRRIRD----SLPPRVKDLHKVSSVLRGFLDLMLVREP 283 Query: 250 KTRIQIQGIKKDPWFRLNYVP 270 R Q + P+ +L P Sbjct: 284 SQRATAQELLGHPFLKLAGPP 304 >6GU6-A nrPDB Length = 302 Score = 118 bits (295), Expect = 6e-27, Method: Compositional matrix adjust. Identities = 73/200 (36%), Positives = 107/200 (53%), Gaps = 4/200 (2%) Query: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYE 76 IGEGT+ V R+ TG VA+K + + + I REIS++K +RHPNIV L + Sbjct: 15 IGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAI-REISLLKELRHPNIVSLQD 73 Query: 77 VLASPSKIYIVLEFVTGG--ELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRD 134 VL S++Y++ EF++ + D I ++ S + Y Q++ + CH + V HRD Sbjct: 74 VLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRD 133 Query: 135 LKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSAADIW 194 LKP+NLL+D G +K++DFGL+ + + T Y +PEVL G + DIW Sbjct: 134 LKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIW 193 Query: 195 SCGVILFVILAGYLPFSETD 214 S G I F LA P D Sbjct: 194 SIGTI-FAELATKKPLFHGD 212 >2BPM-A nrPDB Length = 309 Score = 118 bits (295), Expect = 6e-27, Method: Compositional matrix adjust. Identities = 74/186 (39%), Positives = 104/186 (55%), Gaps = 4/186 (2%) Query: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYE 76 IGEGT+ V ARN TG+ VA+K + T + I REIS++K + HPNIV+L + Sbjct: 15 IGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAI-REISLLKELNHPNIVKLLD 73 Query: 77 VLASPSKIYIVLEFVTGG--ELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRD 134 V+ + +K+Y+V EF+ + D G + + Y QL+ +A CH V HRD Sbjct: 74 VIHTENKLYLVFEFLHQDLKKFMDASALTG-IPLPLIKSYLFQLLQGLAFCHSHRVLHRD 132 Query: 135 LKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSAADIW 194 LKP+NLL++T G +K++DFGL+ V T Y APE+L G Y +A DIW Sbjct: 133 LKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIW 192 Query: 195 SCGVIL 200 S G I Sbjct: 193 SLGCIF 198 >4RC3-A nrPDB Length = 289 Score = 117 bits (293), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 90/293 (30%), Positives = 141/293 (48%), Gaps = 22/293 (7%) Query: 1 MTKKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTI-----LKNRMVDQ 55 M +K +Y+VG +G G F V VAIK + K I L N + Sbjct: 4 MKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGT--R 61 Query: 56 IKREISIMKIVRH--PNIVRLYEVLASPSKIYIVLEFVTG-GELFDRIVHKGRLEESESR 112 + E+ ++K V ++RL + P ++LE +LFD I +G L+E +R Sbjct: 62 VPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELAR 121 Query: 113 KYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTN-GNLKVSDFGLSALPQEGVELLRTTCG 171 +F Q+++AV HCH GV HRD+K EN+L+D N G LK+ DFG AL ++ V G Sbjct: 122 SFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV--YTDFDG 179 Query: 172 TPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPP 231 T Y PE + Y G +A +WS G++L+ ++ G +PF + +I + Sbjct: 180 TRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDE------EIIRGQVFFRQ 233 Query: 232 WFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEVNLDDI 284 S+E + LI L P R + I+ PW + +P +E E++L + Sbjct: 234 RVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLP---QETAEIHLHSL 283 >3BGP-A nrPDB Length = 333 Score = 117 bits (292), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 88/284 (30%), Positives = 138/284 (48%), Gaps = 22/284 (7%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTI-----LKNRMVDQIKREISIMK 64 +Y+VG +G G F V VAIK + K I L N ++ E+ ++K Sbjct: 57 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGT--RVPMEVVLLK 114 Query: 65 IVRH--PNIVRLYEVLASPSKIYIVLEFVTG-GELFDRIVHKGRLEESESRKYFQQLVDA 121 V ++RL + P ++LE +LFD I +G L+E +R +F Q+++A Sbjct: 115 KVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEA 174 Query: 122 VAHCHCKGVYHRDLKPENLLLDTN-GNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEV 180 V HCH GV HRD+K EN+L+D N G LK+ DFG AL ++ V GT Y PE Sbjct: 175 VRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV--YTDFDGTRVYSPPEW 232 Query: 181 LSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFL 240 + Y G +A +WS G++L+ ++ G +PF + +I + S+E + L Sbjct: 233 IRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDE------EIIRGQVFFRQRVSSECQHL 286 Query: 241 IHRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEVNLDDI 284 I L P R + I+ PW + +P +E E++L + Sbjct: 287 IRWCLALRPSDRPTFEEIQNHPWMQDVLLP---QETAEIHLHSL 327 >3TKU-A nrPDB Length = 433 Score = 115 bits (289), Expect = 3e-26, Method: Compositional matrix adjust. Identities = 85/279 (30%), Positives = 135/279 (48%), Gaps = 14/279 (5%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 +E+ + IG G F +V + +T A+KI+ K +LK + E ++ Sbjct: 92 FEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDCQW 151 Query: 71 IVRLYEVLASPSKIYIVLEFVTGGELFDRIVH-KGRLEESESRKYFQQLVDAVAHCHCKG 129 I L+ + +Y+V+++ GG+L + + +L E +R Y ++V A+ H Sbjct: 152 ITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQLH 211 Query: 130 VYHRDLKPENLLLDTNGNLKVSDFGLS-ALPQEGVELLRTTCGTPNYVAPEVL----SGQ 184 HRD+KP+N+LLD NG+++++DFG + +G GTP+Y++PE+L G Sbjct: 212 YVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAMEDGM 271 Query: 185 GYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAE--FSCPPW---FSAEVKF 239 G G D WS GV ++ +L G PF L Y KI E F P S E K Sbjct: 272 GKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVTDVSEEAKD 331 Query: 240 LIHRILDPNPKTRIQ--IQGIKKDPWFR-LNYVPIRARE 275 LI R++ + Q I+ KK +F LN+ IR E Sbjct: 332 LIQRLICSRERRLGQNGIEDFKKHAFFEGLNWENIRNLE 370 >6DC0-A nrPDB Length = 292 Score = 115 bits (289), Expect = 3e-26, Method: Compositional matrix adjust. Identities = 66/205 (32%), Positives = 104/205 (50%), Gaps = 4/205 (1%) Query: 63 MKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAV 122 +++ H NI + EV+ +K Y+ E G++ + + RL E E+ + F+Q+V AV Sbjct: 52 IQLPSHSNITGIVEVILGETKAYVFFE-KDFGDMHSYVRSRKRLREEEAARLFKQIVSAV 110 Query: 123 AHCHCKGVYHRDLKPENLLLDTN--GNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEV 180 AHCH + DLK + T L++ + + + + L G P YV+PE+ Sbjct: 111 AHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEI 170 Query: 181 LSGQG-YDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKF 239 L+ G Y G AAD+WS GV+L+ +L G PF ++D L+ KI +F P S + + Sbjct: 171 LNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKARC 230 Query: 240 LIHRILDPNPKTRIQIQGIKKDPWF 264 LI +L P R+ I PWF Sbjct: 231 LIRSLLRREPSERLTAPEILLHPWF 255 >5TUR-A nrPDB Length = 404 Score = 115 bits (289), Expect = 3e-26, Method: Compositional matrix adjust. Identities = 88/284 (30%), Positives = 138/284 (48%), Gaps = 22/284 (7%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTI-----LKNRMVDQIKREISIMK 64 +Y+VG +G G F V VAIK + K I L N ++ E+ ++K Sbjct: 128 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGT--RVPMEVVLLK 185 Query: 65 IVRH--PNIVRLYEVLASPSKIYIVLEFVTG-GELFDRIVHKGRLEESESRKYFQQLVDA 121 V ++RL + P ++LE +LFD I +G L+E +R +F Q+++A Sbjct: 186 KVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEA 245 Query: 122 VAHCHCKGVYHRDLKPENLLLDTN-GNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEV 180 V HCH GV HRD+K EN+L+D N G LK+ DFG AL ++ V GT Y PE Sbjct: 246 VRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV--YTDFDGTRVYSPPEW 303 Query: 181 LSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFL 240 + Y G +A +WS G++L+ ++ G +PF + +I + S+E + L Sbjct: 304 IRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDE------EIIRGQVFFRQRVSSECQHL 357 Query: 241 IHRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEVNLDDI 284 I L P R + I+ PW + +P +E E++L + Sbjct: 358 IRWCLALRPSDRPTFEEIQNHPWMQDVLLP---QETAEIHLHSL 398 >5CEK-A nrPDB Length = 263 Score = 115 bits (288), Expect = 4e-26, Method: Compositional matrix adjust. Identities = 66/205 (32%), Positives = 104/205 (50%), Gaps = 4/205 (1%) Query: 63 MKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAV 122 +++ H NI + EV+ +K Y+ E G++ + + RL E E+ + F+Q+V AV Sbjct: 55 IQLPSHSNITGIVEVILGETKAYVFFE-KDFGDMHSYVRSRKRLREEEAARLFKQIVSAV 113 Query: 123 AHCHCKGVYHRDLKPENLLLDTN--GNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEV 180 AHCH + DLK + T L++ + + + + L G P YV+PE+ Sbjct: 114 AHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEI 173 Query: 181 LSGQG-YDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKF 239 L+ G Y G AAD+WS GV+L+ +L G PF ++D L+ KI +F P S + + Sbjct: 174 LNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKARC 233 Query: 240 LIHRILDPNPKTRIQIQGIKKDPWF 264 LI +L P R+ I PWF Sbjct: 234 LIRSLLRREPSERLTAPEILLHPWF 258 >4KRC-A nrPDB Length = 317 Score = 114 bits (286), Expect = 6e-26, Method: Compositional matrix adjust. Identities = 78/215 (36%), Positives = 114/215 (53%), Gaps = 7/215 (3%) Query: 5 MRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMK 64 M +++ +G GT+A V N TG VA+K + + + REIS+MK Sbjct: 1 MSSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDS--EEGTPSTAIREISLMK 58 Query: 65 IVRHPNIVRLYEVLASPSKIYIVLEFVTGG---ELFDRIV-HKGRLEESESRKYFQ-QLV 119 ++H NIVRLY+V+ + +K+ +V EF+ + R V + R E KYFQ QL+ Sbjct: 59 ELKHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLL 118 Query: 120 DAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPE 179 +A CH + HRDLKP+NLL++ G LK+ DFGL+ V + T Y AP+ Sbjct: 119 QGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPD 178 Query: 180 VLSGQGYDGSAADIWSCGVILFVILAGYLPFSETD 214 VL G ++ DIWSCG IL ++ G F T+ Sbjct: 179 VLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTN 213 >4AW2-A nrPDB Length = 437 Score = 114 bits (286), Expect = 7e-26, Method: Compositional matrix adjust. Identities = 82/276 (29%), Positives = 133/276 (48%), Gaps = 14/276 (5%) Query: 3 KKMR-RVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREIS 61 K+MR +E+ + IG G F +V + + A+KI+ K +LK + E Sbjct: 67 KQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERD 126 Query: 62 IMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVH-KGRLEESESRKYFQQLVD 120 ++ I L+ + +Y+V+++ GG+L + + RL E +R Y ++V Sbjct: 127 VLVNGDSKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEEMARFYLAEMVI 186 Query: 121 AVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLS-ALPQEGVELLRTTCGTPNYVAPE 179 A+ H HRD+KP+N+L+D NG+++++DFG L ++G GTP+Y++PE Sbjct: 187 AIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPE 246 Query: 180 VLS----GQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKI--NAAEFSCPPW- 232 +L G+G G D WS GV ++ +L G PF L Y KI + F P Sbjct: 247 ILQAMEGGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPTQV 306 Query: 233 --FSAEVKFLIHRILDPNPKTRIQ--IQGIKKDPWF 264 S K LI R++ Q I+ KK P+F Sbjct: 307 TDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFF 342 >4CRS-A nrPDB Length = 341 Score = 114 bits (285), Expect = 7e-26, Method: Compositional matrix adjust. Identities = 95/289 (32%), Positives = 142/289 (49%), Gaps = 31/289 (10%) Query: 20 GTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQI---KREISIMKIVRHPNIVRLYE 76 G F KV A +T + AIK + K I+ VD + KR + VRHP +V L+ Sbjct: 23 GHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVNLFA 82 Query: 77 VLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDLK 136 + + V+E+ GG+L I H E + Y +V + + H + +RDLK Sbjct: 83 CFQTKEHVCFVMEYAAGGDLMMHI-HTDVFSEPRAVFYAACVVLGLQYLHEHKIVYRDLK 141 Query: 137 PENLLLDTNGNLKVSDFGLSALPQEGV---ELLRTTCGTPNYVAPEVLSGQGYDGSAADI 193 +NLLLDT G +K++DFGL +EG+ + T CGTP ++APEVL+ Y A D Sbjct: 142 LDNLLLDTEGFVKIADFGLC---KEGMGYGDRTSTFCGTPEFLAPEVLTETSY-TRAVDW 197 Query: 194 WSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILDPNPKTRI 253 W GV+++ +L G PF D ++ I E P + S E ++ R+L NP+ R+ Sbjct: 198 WGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRL 257 Query: 254 -----QIQGIKKDPWFRL-------------NYVP-IRAREEEEVNLDD 283 + +KK P+FRL ++P IR RE+ N DD Sbjct: 258 GASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVS-NFDD 305 >2Q0N-A nrPDB Length = 301 Score = 112 bits (280), Expect = 4e-25, Method: Compositional matrix adjust. Identities = 76/255 (29%), Positives = 131/255 (51%), Gaps = 16/255 (6%) Query: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYE 76 IGEG+ V A +G VA+K K + K + + + E+ IM+ +H N+V +Y Sbjct: 37 IGEGSTGIVCIATVRSSGKLVAVK---KMDLRKQQRRELLFNEVVIMRDYQHENVVEMYN 93 Query: 77 VLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDLK 136 ++++V+EF+ GG L D + H R+ E + ++ A++ H +GV HRD+K Sbjct: 94 SYLVGDELWVVMEFLEGGALTDIVTHT-RMNEEQIAAVCLAVLQALSVLHAQGVIHRDIK 152 Query: 137 PENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSAADIWSC 196 +++LL +G +K+SDFG A + V ++ GTP ++APE++S Y G DIWS Sbjct: 153 SDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPY-GPEVDIWSL 211 Query: 197 GVILFVILAGYLP-FSETDLPGLYRKINAAEFSCPPWF------SAEVKFLIHRILDPNP 249 G+++ ++ G P F+E L + + + PP S +K + R+L +P Sbjct: 212 GIMVIEMVDGEPPYFNEPPL----KAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDP 267 Query: 250 KTRIQIQGIKKDPWF 264 R + K P+ Sbjct: 268 AQRATAAELLKHPFL 282 >4OTD-A nrPDB Length = 341 Score = 112 bits (279), Expect = 4e-25, Method: Compositional matrix adjust. Identities = 90/270 (33%), Positives = 137/270 (50%), Gaps = 17/270 (6%) Query: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR---HPNIVR 73 +G G F KV + +G+ AIK + K I+ V+ + E I+ V HP +V Sbjct: 20 LGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTSAGHPFLVN 79 Query: 74 LYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHR 133 L+ +P + V+E+ GG+L I H E + Y +V + H + +R Sbjct: 80 LFGCFQTPEHVCFVMEYSAGGDLMLHI-HSDVFSEPRAIFYSACVVLGLQFLHEHKIVYR 138 Query: 134 DLKPENLLLDTNGNLKVSDFGLSALPQEGV---ELLRTTCGTPNYVAPEVLSGQGYDGSA 190 DLK +NLLLDT G +K++DFGL +EG+ + T CGTP ++APEVL+ Y A Sbjct: 139 DLKLDNLLLDTEGYVKIADFGLC---KEGMGYGDRTSTFCGTPEFLAPEVLTDTSYT-RA 194 Query: 191 ADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILDPNPK 250 D W GV+L+ +L G PF D ++ I E P + SAE ++ R+L NP+ Sbjct: 195 VDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPE 254 Query: 251 TRI-----QIQGIKKDPWFR-LNYVPIRAR 274 R+ + +KK P+FR L + + AR Sbjct: 255 RRLGSSERDAEDVKKQPFFRTLGWEALLAR 284 >4JDH-A nrPDB Length = 346 Score = 112 bits (279), Expect = 5e-25, Method: Compositional matrix adjust. Identities = 76/255 (29%), Positives = 131/255 (51%), Gaps = 16/255 (6%) Query: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYE 76 IGEG+ V A +G VA+K K + K + + + E+ IM+ +H N+V +Y Sbjct: 82 IGEGSTGIVCIATVRSSGKLVAVK---KMDLRKQQRRELLFNEVVIMRDYQHENVVEMYN 138 Query: 77 VLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDLK 136 ++++V+EF+ GG L D + H R+ E + ++ A++ H +GV HRD+K Sbjct: 139 SYLVGDELWVVMEFLEGGALTDIVTHT-RMNEEQIAAVCLAVLQALSVLHAQGVIHRDIK 197 Query: 137 PENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSAADIWSC 196 +++LL +G +K+SDFG A + V ++ GTP ++APE++S Y G DIWS Sbjct: 198 SDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPY-GPEVDIWSL 256 Query: 197 GVILFVILAGYLP-FSETDLPGLYRKINAAEFSCPPWF------SAEVKFLIHRILDPNP 249 G+++ ++ G P F+E L + + + PP S +K + R+L +P Sbjct: 257 GIMVIEMVDGEPPYFNEPPL----KAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDP 312 Query: 250 KTRIQIQGIKKDPWF 264 R + K P+ Sbjct: 313 AQRATAAELLKHPFL 327 >4XBR-A nrPDB Length = 366 Score = 112 bits (279), Expect = 5e-25, Method: Compositional matrix adjust. Identities = 76/255 (29%), Positives = 131/255 (51%), Gaps = 16/255 (6%) Query: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYE 76 IGEG+ V A +G VA+K K + K + + + E+ IM+ +H N+V +Y Sbjct: 102 IGEGSTGIVCIATVRSSGKLVAVK---KMDLRKQQRRELLFNEVVIMRDYQHENVVEMYN 158 Query: 77 VLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDLK 136 ++++V+EF+ GG L D + H R+ E + ++ A++ H +GV HRD+K Sbjct: 159 SYLVGDELWVVMEFLEGGALTDIVTHT-RMNEEQIAAVCLAVLQALSVLHAQGVIHRDIK 217 Query: 137 PENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSAADIWSC 196 +++LL +G +K+SDFG A + V ++ GTP ++APE++S Y G DIWS Sbjct: 218 SDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPY-GPEVDIWSL 276 Query: 197 GVILFVILAGYLP-FSETDLPGLYRKINAAEFSCPPWF------SAEVKFLIHRILDPNP 249 G+++ ++ G P F+E L + + + PP S +K + R+L +P Sbjct: 277 GIMVIEMVDGEPPYFNEPPL----KAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDP 332 Query: 250 KTRIQIQGIKKDPWF 264 R + K P+ Sbjct: 333 AQRATAAELLKHPFL 347 >6FD3-A nrPDB Length = 300 Score = 111 bits (278), Expect = 5e-25, Method: Compositional matrix adjust. Identities = 77/261 (29%), Positives = 131/261 (50%), Gaps = 8/261 (3%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 KY IG+G V A + TG VAIK M K + I EI +M+ ++P Sbjct: 23 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKEL---IINEILVMRENKNP 79 Query: 70 NIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKG 129 NIV + ++++V+E++ GG L D +V + ++E + ++ + A+ H Sbjct: 80 NIVNYLDSYLVGDELWVVMEYLAGGSLTD-VVTETCMDEGQIAAVCRECLQALDFLHSNQ 138 Query: 130 VYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGS 189 V HRD+K +N+LL +G++K++DFG A T GTP ++APEV++ + Y G Sbjct: 139 VIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAY-GP 197 Query: 190 AADIWSCGVILFVILAGYLPF-SETDLPGLY--RKINAAEFSCPPWFSAEVKFLIHRILD 246 DIWS G++ ++ G P+ +E L LY E P SA + ++R L+ Sbjct: 198 KVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLE 257 Query: 247 PNPKTRIQIQGIKKDPWFRLN 267 + R + + + P+ +L+ Sbjct: 258 MDVDRRGSAKELLQHPFLKLD 278 >2HW6-A nrPDB Length = 307 Score = 111 bits (277), Expect = 7e-25, Method: Compositional matrix adjust. Identities = 85/298 (28%), Positives = 137/298 (45%), Gaps = 46/298 (15%) Query: 9 GKYE-----VGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREI-SI 62 GK+E +GEG +AKV+ A + G A+KI+ K ++ RE+ ++ Sbjct: 8 GKFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQA---GHSRSRVFREVETL 64 Query: 63 MKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAV 122 + + NI+ L E ++ Y+V E + GG + I + E E+ + + + A+ Sbjct: 65 YQCQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAAL 124 Query: 123 AHCHCKGVYHRDLKPENLLLDTN---GNLKVSDFGL--------SALPQEGVELLRTTCG 171 H KG+ HRDLKPEN+L ++ +K+ DF L S P EL T CG Sbjct: 125 DFLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELT-TPCG 183 Query: 172 TPNYVAPEVL-----SGQGYDGSAADIWSCGVILFVILAGYLPF---------------S 211 + Y+APEV+ YD D+WS GV+L+++L+GY PF Sbjct: 184 SAEYMAPEVVEVFTDQATFYD-KRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVC 242 Query: 212 ETDLPGLYRKINAAEFSCP--PW--FSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFR 265 L+ I ++ P W S+E K LI ++L + K R+ + + PW + Sbjct: 243 RVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQ 300 >4FIE-A nrPDB Length = 423 Score = 111 bits (277), Expect = 8e-25, Method: Compositional matrix adjust. Identities = 76/255 (29%), Positives = 131/255 (51%), Gaps = 16/255 (6%) Query: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYE 76 IGEG+ V A +G VA+K M + K + + + E+ IM+ +H N+V +Y Sbjct: 159 IGEGSTGIVCIATVRSSGKLVAVKKM---DLRKQQRRELLFNEVVIMRDYQHENVVEMYN 215 Query: 77 VLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDLK 136 ++++V+EF+ GG L D + H R+ E + ++ A++ H +GV HRD+K Sbjct: 216 SYLVGDELWVVMEFLEGGALTDIVTHT-RMNEEQIAAVCLAVLQALSVLHAQGVIHRDIK 274 Query: 137 PENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSAADIWSC 196 +++LL +G +K+SDFG A + V ++ GTP ++APE++S Y G DIWS Sbjct: 275 SDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPY-GPEVDIWSL 333 Query: 197 GVILFVILAGYLP-FSETDLPGLYRKINAAEFSCPPWF------SAEVKFLIHRILDPNP 249 G+++ ++ G P F+E L + + + PP S +K + R+L +P Sbjct: 334 GIMVIEMVDGEPPYFNEPPL----KAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDP 389 Query: 250 KTRIQIQGIKKDPWF 264 R + K P+ Sbjct: 390 AQRATAAELLKHPFL 404 >1TKI-A nrPDB Length = 321 Score = 110 bits (276), Expect = 8e-25, Method: Compositional matrix adjust. Identities = 77/265 (29%), Positives = 127/265 (47%), Gaps = 17/265 (6%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQI--KREISIMKIVR 67 KY + +G G F V T + MAK +K + DQ+ K+EISI+ I R Sbjct: 6 KYMIAEDLGRGEFGIVHRCVETSSKKTY----MAK--FVKVKGTDQVLVKKEISILNIAR 59 Query: 68 HPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKG-RLEESESRKYFQQLVDAVAHCH 126 H NI+ L+E S ++ ++ EF++G ++F+RI L E E Y Q+ +A+ H Sbjct: 60 HRNILHLHESFESMEELVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCEALQFLH 119 Query: 127 CKGVYHRDLKPENLLLDT--NGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQ 184 + H D++PEN++ T + +K+ +FG + + G + R P Y APEV Sbjct: 120 SHNIGHFDIRPENIIYQTRRSSTIKIIEFGQARQLKPG-DNFRLLFTAPEYYAPEV-HQH 177 Query: 185 GYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCP----PWFSAEVKFL 240 +A D+WS G +++V+L+G PF + I AE++ S E Sbjct: 178 DVVSTATDMWSLGTLVYVLLSGINPFLAETNQQIIENIMNAEYTFDEEAFKEISIEAMDF 237 Query: 241 IHRILDPNPKTRIQIQGIKKDPWFR 265 + R+L K+R+ + PW + Sbjct: 238 VDRLLVKERKSRMTASEALQHPWLK 262 >3PPZ-A nrPDB Length = 309 Score = 110 bits (275), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 85/269 (31%), Positives = 130/269 (48%), Gaps = 30/269 (11%) Query: 13 VGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIV 72 + IG G+F V R G +VA+KI+ + R V++ RE++IMK +RHPNIV Sbjct: 41 IKEKIGAGSFGTVH--RAEWHGSDVAVKILMEQDFHAER-VNEFLREVAIMKRLRHPNIV 97 Query: 73 RLYEVLASPSKIYIVLEFVTGGELFDRIVHK-GRLEESESRKYFQQLVDAVA-----HCH 126 + P + IV E+++ G L+ R++HK G E+ + R+ D H Sbjct: 98 LFMGAVTQPPNLSIVTEYLSRGSLY-RLLHKSGAREQLDERRRLSMAYDVAKGMNYLHNR 156 Query: 127 CKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGY 186 + HRDLK NLL+D +KV DFGLS L ++ GTP ++APEVL + Sbjct: 157 NPPIVHRDLKSPNLLVDKKYTVKVCDFGLSRLKASTFLSSKSAAGTPEWMAPEVLRDEPS 216 Query: 187 DGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILD 246 + +D++S GVIL+ + P+ +N A+ A V F R+ Sbjct: 217 N-EKSDVYSFGVILWELATLQQPWG---------NLNPAQ------VVAAVGFKCKRLEI 260 Query: 247 P---NPKTRIQIQGI-KKDPWFRLNYVPI 271 P NP+ I+G +PW R ++ I Sbjct: 261 PRNLNPQVAAIIEGCWTNEPWKRPSFATI 289 >3DAK-A nrPDB Length = 290 Score = 110 bits (274), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 68/214 (31%), Positives = 111/214 (51%), Gaps = 17/214 (7%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 YE+ IG G A V+ A + VAIK + +D++ +EI M HPN Sbjct: 12 YELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKC--QTSMDELLKEIQAMSQCHHPN 69 Query: 71 IVRLYEVLASPSKIYIVLEFVTGGELFDRIVH--------KGRLEESESRKYFQQLVDAV 122 IV Y ++++V++ ++GG + D I H G L+ES +++++ + Sbjct: 70 IVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEGL 129 Query: 123 AHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLR-----TTCGTPNYVA 177 + H G HRD+K N+LL +G+++++DFG+SA G ++ R T GTP ++A Sbjct: 130 EYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWMA 189 Query: 178 PEVLSG-QGYDGSAADIWSCGVILFVILAGYLPF 210 PEV+ +GYD ADIWS G+ + G P+ Sbjct: 190 PEVMEQVRGYD-FKADIWSFGITAIELATGAAPY 222 >4AU8-A nrPDB Length = 296 Score = 110 bits (274), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 72/200 (36%), Positives = 105/200 (52%), Gaps = 19/200 (9%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIK-------REISI 62 KYE IGEGT+ V A+N +T + VA+K + R+ D + REI + Sbjct: 7 KYEKLEKIGEGTYGTVFKAKNRETHEIVALK--------RVRLDDDDEGVPSSALREICL 58 Query: 63 MKIVRHPNIVRLYEVLASPSKIYIVLEFVTGG--ELFDRIVHKGRLEESESRKYFQQLVD 120 +K ++H NIVRL++VL S K+ +V EF + FD G L+ + + QL+ Sbjct: 59 LKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSC--NGDLDPEIVKSFLFQLLK 116 Query: 121 AVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEV 180 + CH + V HRDLKP+NLL++ NG LK++DFGL+ V T Y P+V Sbjct: 117 GLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDV 176 Query: 181 LSGQGYDGSAADIWSCGVIL 200 L G ++ D+WS G I Sbjct: 177 LFGAKLYSTSIDMWSAGCIF 196 >3NIZ-A nrPDB Length = 311 Score = 109 bits (273), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 90/291 (30%), Positives = 141/291 (48%), Gaps = 42/291 (14%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIK---IMAKSTILKNRMVDQIKREISIMKIV 66 KY+ +GEGT+ V A+++ G VA+K + A+ + + + REIS++K + Sbjct: 22 KYQKLEKVGEGTYGVVYKAKDS-QGRIVALKRIRLDAEDEGIPSTAI----REISLLKEL 76 Query: 67 RHPNIVRLYEVLASPSKIYIVLEFVTGG--ELFDRIVHKGRLEESESRKYFQQLVDAVAH 124 HPNIV L +V+ S + +V EF+ ++ D +K L++S+ + Y QL+ VAH Sbjct: 77 HHPNIVSLIDVIHSERCLTLVFEFMEKDLKKVLDE--NKTGLQDSQIKIYLYQLLRGVAH 134 Query: 125 CHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQ 184 CH + HRDLKP+NLL++++G LK++DFGL+ V T Y AP+VL G Sbjct: 135 CHQHRILHRDLKPQNLLINSDGALKLADFGLARAFGIPVRSYTHEVVTLWYRAPDVLMGS 194 Query: 185 GYDGSAADIWSCGVILFVILAG-----------YLP--FSETDLPG-----------LYR 220 ++ DIWS G I ++ G LP FS P L++ Sbjct: 195 KKYSTSVDIWSIGCIFAEMITGKPLFPGVTDDDQLPKIFSILGTPNPREWPQVQELPLWK 254 Query: 221 KINAAEFSCPPW------FSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFR 265 + F PW F E L+ +L +P RI + P+F+ Sbjct: 255 QRTFQVFEKKPWSSIIPGFCQEGIDLLSNMLCFDPNKRISARDAMNHPYFK 305 >4TNB-A nrPDB Length = 590 Score = 108 bits (271), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 84/286 (29%), Positives = 139/286 (48%), Gaps = 14/286 (4%) Query: 15 RTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRL 74 R +G+G F +V + TG A K + K I K + E I++ V +V L Sbjct: 190 RVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNL 249 Query: 75 YEVLASPSKIYIVLEFVTGGELFDRIVHKGR--LEESESRKYFQQLVDAVAHCHCKGVYH 132 + + +VL + GG+L I + G EE + Y +++ + H + + Sbjct: 250 AYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHHENTVY 309 Query: 133 RDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSAAD 192 RDLKPEN+LLD G++++SD GL+ EG +L+R GT Y+APEVL+ Q Y G + D Sbjct: 310 RDLKPENILLDDYGHIRISDLGLAVKIPEG-DLIRGRVGTVGYMAPEVLNNQRY-GLSPD 367 Query: 193 IWSCGVILFVILAGYLPF----SETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILDPN 248 W G +++ ++ G PF + + R++ E FS E K + +L + Sbjct: 368 YWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKD 427 Query: 249 PKTRIQIQ-----GIKKDPWFR-LNYVPIRAREEEEVNLDDIRAVF 288 K R+ Q +K+ P+FR +N+ + A + + D RAV+ Sbjct: 428 AKQRLGCQEEEAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVY 473 >2UV2-A nrPDB Length = 325 Score = 108 bits (271), Expect = 4e-24, Method: Compositional matrix adjust. Identities = 81/284 (28%), Positives = 144/284 (50%), Gaps = 18/284 (6%) Query: 1 MTKKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTI--LKNRMVDQIKR 58 +T+ + +E+ +G+G F KV A+N +T A K++ + L++ MV Sbjct: 29 VTRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMV----- 83 Query: 59 EISIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGR-LEESESRKYFQQ 117 EI I+ HPNIV+L + + ++I++EF GG + ++ R L ES+ + +Q Sbjct: 84 EIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQ 143 Query: 118 LVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVA 177 +DA+ + H + HRDLK N+L +G++K++DFG+SA ++ + GTP ++A Sbjct: 144 TLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMA 203 Query: 178 PEVL-----SGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAE---FSC 229 PEV+ + YD AD+WS G+ L + P E + + KI +E + Sbjct: 204 PEVVMCETSKDRPYD-YKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQ 262 Query: 230 PPWFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLNY-VPIR 272 P +S+ K + + L+ N R + + P+ ++ PIR Sbjct: 263 PSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPIR 306 >4EQM-A nrPDB Length = 294 Score = 108 bits (271), Expect = 4e-24, Method: Compositional matrix adjust. Identities = 62/203 (30%), Positives = 105/203 (51%), Gaps = 2/203 (0%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 +Y++ +G G + V A +T VAIK + K + + +RE+ + H Sbjct: 12 RYKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETLKRFEREVHNSSQLSHQ 71 Query: 70 NIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKG 129 NIV + +V Y+V+E++ G L + I G L + + Q++D + H H Sbjct: 72 NIVSMIDVDEEDDCYYLVMEYIEGPTLSEYIESHGPLSVDTAINFTNQILDGIKHAHDMR 131 Query: 130 VYHRDLKPENLLLDTNGNLKVSDFGLS-ALPQEGVELLRTTCGTPNYVAPEVLSGQGYDG 188 + HRD+KP+N+L+D+N LK+ DFG++ AL + + GT Y +PE G+ D Sbjct: 132 IVHRDIKPQNILIDSNKTLKIFDFGIAKALSETSLTQTNHVLGTVQYFSPEQAKGEATD- 190 Query: 189 SAADIWSCGVILFVILAGYLPFS 211 DI+S G++L+ +L G PF+ Sbjct: 191 ECTDIYSIGIVLYEMLVGEPPFN 213 >1V0B-A nrPDB Length = 288 Score = 108 bits (271), Expect = 4e-24, Method: Compositional matrix adjust. Identities = 72/199 (36%), Positives = 110/199 (55%), Gaps = 6/199 (3%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 KY IGEGT+ V A+N + G+ A+K + + I REISI+K ++H Sbjct: 3 KYHGLEKIGEGTYGVVYKAQN-NYGETFALKKIRLEKEDEGIPSTTI-REISILKELKHS 60 Query: 70 NIVRLYEVLASPSKIYIVLEFVTGG--ELFDRIVHKGRLEESESRKYFQQLVDAVAHCHC 127 NIV+LY+V+ + ++ +V E + +L D V +G LE ++ + QL++ +A+CH Sbjct: 61 NIVKLYDVIHTKKRLVLVFEHLDQDLKKLLD--VCEGGLESVTAKSFLLQLLNGIAYCHD 118 Query: 128 KGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYD 187 + V HRDLKP+NLL++ G LK++DFGL+ V T Y AP+VL G Sbjct: 119 RRVLHRDLKPQNLLINREGELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVLMGSKKY 178 Query: 188 GSAADIWSCGVILFVILAG 206 + DIWS G I ++ G Sbjct: 179 STTIDIWSVGCIFAEMVNG 197 >6HXF-B nrPDB Length = 302 Score = 108 bits (270), Expect = 5e-24, Method: Compositional matrix adjust. Identities = 76/261 (29%), Positives = 134/261 (51%), Gaps = 11/261 (4%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 +E+ +G+G F KV A+N +TG A K++ + + + D I EI I+ HP Sbjct: 21 WEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKS--EEELEDYI-VEIEILATCDHPY 77 Query: 71 IVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGR-LEESESRKYFQQLVDAVAHCHCKG 129 IV+L K++I++EF GG + ++ R L E + + +Q+++A+ H K Sbjct: 78 IVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKR 137 Query: 130 VYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGS 189 + HRDLK N+L+ G+++++DFG+SA + ++ + GTP ++APEV+ + + Sbjct: 138 IIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDT 197 Query: 190 A----ADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAE---FSCPPWFSAEVKFLIH 242 ADIWS G+ L + P E + + KI ++ P +S E + + Sbjct: 198 PYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLK 257 Query: 243 RILDPNPKTRIQIQGIKKDPW 263 LD NP+TR + + P+ Sbjct: 258 IALDKNPETRPSAAQLLEHPF 278 >3Q53-A nrPDB Length = 306 Score = 108 bits (269), Expect = 6e-24, Method: Compositional matrix adjust. Identities = 74/246 (30%), Positives = 124/246 (50%), Gaps = 8/246 (3%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 KY IG+G V A + TG VAI+ M K + I EI +M+ ++P Sbjct: 22 KYTRFEKIGQGASGTVYTAMDVATGQEVAIRQMNLQQQPKKEL---IINEILVMRENKNP 78 Query: 70 NIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKG 129 NIV + ++++V+E++ GG L D +V + ++E + ++ + A+ H Sbjct: 79 NIVNYLDSYLVGDELWVVMEYLAGGSLTD-VVTETCMDEGQIAAVCRECLQALEFLHSNQ 137 Query: 130 VYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGS 189 V HRD+K +N+LL +G++K++DFG A T GTP ++APEV++ + Y G Sbjct: 138 VIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAY-GP 196 Query: 190 AADIWSCGVILFVILAGYLPF-SETDLPGLY--RKINAAEFSCPPWFSAEVKFLIHRILD 246 DIWS G++ ++ G P+ +E L LY E P SA + ++R L+ Sbjct: 197 KVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLE 256 Query: 247 PNPKTR 252 + + R Sbjct: 257 MDVEKR 262 >4LQP-A nrPDB Length = 508 Score = 108 bits (269), Expect = 6e-24, Method: Compositional matrix adjust. Identities = 86/331 (25%), Positives = 137/331 (41%), Gaps = 72/331 (21%) Query: 15 RTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRL 74 + IG+G F +V+ + DTG A+K + KS + K + +K E ++ P +V L Sbjct: 108 KVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKDQLAHVKAERDVLAGSDSPWVVSL 167 Query: 75 YEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRD 134 Y +Y+++EF+ GG+L ++ E +R Y + + A+ H G HR Sbjct: 168 YYSFQDAQYLYLIMEFLPGGDLMTMLIRWQLFTEDVTRFYMAECILAIETIHKLGFIHRA 227 Query: 135 LKPENLLLD----------------------------------TNG-------------- 146 +KP+N+L+D TNG Sbjct: 228 IKPDNILIDIRGHIKLSDFGLSTGFHKTHDSNYYKKLLQQDEATNGISKPGTYNANTTDT 287 Query: 147 -----NLKVSDFGLSALPQEGVELLR--------TTCGTPNYVAPEVLSGQGYDGSAADI 193 + V L+ ++ ++ R +T GTP+Y+APE+ QGY G D Sbjct: 288 ANKRQTMVVDSISLTMSNRQQIQTWRKSRRLMAYSTVGTPDYIAPEIFLYQGY-GQECDW 346 Query: 194 WSCGVILFVILAGYLPFSETDLPGLYRKI----NAAEFSCPPWFSAEVKFLIHRILDPNP 249 WS G I++ L G+ PF YRKI +F S E + LI R+L + Sbjct: 347 WSLGAIMYECLIGWPPFCSETPQETYRKIMNFEQTLQFPDDIHISYEAEDLIRRLL-THA 405 Query: 250 KTRIQIQG----IKKDPWFR-LNYVPIRARE 275 R+ G IK P+FR +++ IR E Sbjct: 406 DQRLGRHGGADEIKSHPFFRGVDWNTIRQVE 436 >3ZDU-A nrPDB Length = 325 Score = 108 bits (269), Expect = 6e-24, Method: Compositional matrix adjust. Identities = 71/214 (33%), Positives = 110/214 (51%), Gaps = 9/214 (4%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIK-REISIMKIVRHP 69 YE +GEG++ V ++ +TG VAIKI + + V++I REI +K H Sbjct: 5 YETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERP---EQSVNKIAMREIKFLKQFHHE 61 Query: 70 NIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGR-LEESESRKYFQQLVDAVAHCHCK 128 N+V L EV KI++V EF+ + D + H LE RKY Q++ A+ + H Sbjct: 62 NLVNLIEVFRQKKKIHLVFEFI-DHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSN 120 Query: 129 GVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDG 188 + HRD+KPEN+L+ +G K+ DFG + ++ T Y APE++ G Sbjct: 121 NIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYDDEVATRWYRAPELVLKDTSYG 180 Query: 189 SAADIWSCGVILFVILAG--YLPFSETDLPGLYR 220 DIW+ G ++ + G YLP S +DL L++ Sbjct: 181 KPVDIWALGCMIIEMATGNPYLP-SSSDLDLLHK 213 >3LM0-A nrPDB Length = 327 Score = 108 bits (269), Expect = 7e-24, Method: Compositional matrix adjust. Identities = 77/268 (28%), Positives = 134/268 (50%), Gaps = 23/268 (8%) Query: 13 VGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVD---QIKREISIMKIVRH- 68 + +G G FA V+ + TG A K + K + R D +I EI+++++ + Sbjct: 33 TSKELGRGKFAVVRQCISKSTGQEYAAKFLKK----RRRGQDCRAEILHEIAVLELAKSC 88 Query: 69 PNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHK--GRLEESESRKYFQQLVDAVAHCH 126 P ++ L+EV + S+I ++LE+ GGE+F + + + E++ + +Q+++ V + H Sbjct: 89 PRVINLHEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLH 148 Query: 127 CKGVYHRDLKPENLLLDT---NGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSG 183 + H DLKP+N+LL + G++K+ DFG+S E LR GTP Y+APE+L+ Sbjct: 149 QNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACE-LREIMGTPEYLAPEILN- 206 Query: 184 QGYD--GSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFL- 240 YD +A D+W+ G+I +++L PF D Y I+ + V L Sbjct: 207 --YDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFSSVSQLA 264 Query: 241 ---IHRILDPNPKTRIQIQGIKKDPWFR 265 I +L NP+ R + W + Sbjct: 265 TDFIQSLLVKNPEKRPTAEICLSHSWLQ 292 >3COM-A nrPDB Length = 314 Score = 107 bits (267), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 78/277 (28%), Positives = 136/277 (49%), Gaps = 28/277 (10%) Query: 1 MTKKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREI 60 +TK+ V ++V +GEG++ V A + +TG VAIK + + L+ +I +EI Sbjct: 23 LTKQPEEV--FDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQ-----EIIKEI 75 Query: 61 SIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGR-LEESESRKYFQQLV 119 SIM+ P++V+ Y + ++IV+E+ G + D I + + L E E Q + Sbjct: 76 SIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTL 135 Query: 120 DAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPE 179 + + H HRD+K N+LL+T G+ K++DFG++ + + T GTP ++APE Sbjct: 136 KGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPE 195 Query: 180 VLSGQGYDGSAADIWSCGVILFVILAGYLPFSE-----------TDLPGLYRKINAAEFS 228 V+ GY+ ADIWS G+ + G P+++ T+ P +RK Sbjct: 196 VIQEIGYN-CVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRK------- 247 Query: 229 CPPWFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFR 265 P +S + + L +P+ R + + P+ R Sbjct: 248 -PELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVR 283 >5J5T-A nrPDB Length = 370 Score = 107 bits (267), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 64/191 (33%), Positives = 105/191 (54%), Gaps = 7/191 (3%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 +E+ + IG GT+ V ARN +TG+ AIK++ + +++EI +MK +HPN Sbjct: 6 FELIQRIGSGTYGDVYKARNVNTGELAAIKVIK---LEPGEDFAVVQQEIIMMKDCKHPN 62 Query: 71 IVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGV 130 IV + K++I +EF GG L D G L E + ++ + + + H KG Sbjct: 63 IVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSKGK 122 Query: 131 YHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQ---GYD 187 HRD+K N+LL NG++K++DFG+SA + + GTP ++APEV + + GY+ Sbjct: 123 MHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKAFIGTPYWMAPEVAAVERKGGYN 182 Query: 188 GSAADIWSCGV 198 D+W+ G+ Sbjct: 183 -QLCDLWAVGI 192 >3ORP-A nrPDB Length = 311 Score = 107 bits (267), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 76/267 (28%), Positives = 125/267 (46%), Gaps = 16/267 (5%) Query: 1 MTKKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREI 60 MT +YE+G +G G ++V AR+ +VA+K++ + +RE Sbjct: 4 MTTPSHLSDRYELGEILGFGGMSEVHLARDLRDHRDVAVKVLRADLARDPSFYLRFRREA 63 Query: 61 SIMKIVRHPNIVRLY-----EVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYF 115 + HP IV +Y E A P YIV+E+V G L D + +G + + + Sbjct: 64 QNAAALNHPAIVAVYDTGEAETPAGPLP-YIVMEYVDGVTLRDIVHTEGPMTPKRAIEVI 122 Query: 116 QQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLS-ALPQEGVELLRTTC--GT 172 A+ H G+ HRD+KP N+++ +KV DFG++ A+ G + +T GT Sbjct: 123 ADACQALNFSHQNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGT 182 Query: 173 PNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPP- 231 Y++PE G D +D++S G +L+ +L G PF+ D P + E PP Sbjct: 183 AQYLSPEQARGDSVDAR-SDVYSLGCVLYEVLTGEPPFT-GDSPVSVAYQHVREDPIPPS 240 Query: 232 ----WFSAEVKFLIHRILDPNPKTRIQ 254 SA++ ++ + L NP+ R Q Sbjct: 241 ARHEGLSADLDAVVLKALAKNPENRYQ 267 >3M42-A nrPDB Length = 299 Score = 105 bits (263), Expect = 3e-23, Method: Compositional matrix adjust. Identities = 86/281 (30%), Positives = 132/281 (46%), Gaps = 50/281 (17%) Query: 3 KKMRRVGKYEV-GRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREIS 61 KK + Y+V + +G G KV N T + A+K++ + +RE+ Sbjct: 11 KKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCP--------KARREVE 62 Query: 62 I-MKIVRHPNIVRL---YEVLASPSK-IYIVLEFVTGGELFDRIVHKG--RLEESESRKY 114 + + + P+IVR+ YE L + K + IV+E + GGELF RI +G E E+ + Sbjct: 63 LHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEI 122 Query: 115 FQQLVDAVAHCHCKGVYHRDLKPENLLLDT---NGNLKVSDFGLSALPQEGVELLRTTCG 171 + + +A+ + H + HRD+KPENLL + N LK++DFG + Sbjct: 123 MKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFA--------------- 167 Query: 172 TPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETD----LPGLYRKINAA-- 225 + +G+ YD S D+WS GVI++++L GY PF PG+ +I Sbjct: 168 -------KETTGEKYDKS-CDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQY 219 Query: 226 EFSCPPW--FSAEVKFLIHRILDPNPKTRIQIQGIKKDPWF 264 EF P W S EVK LI +L P R+ I PW Sbjct: 220 EFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 260 >6CKI-A nrPDB Length = 316 Score = 105 bits (261), Expect = 5e-23, Method: Compositional matrix adjust. Identities = 84/285 (29%), Positives = 132/285 (46%), Gaps = 39/285 (13%) Query: 16 TIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIM-KIVRHPNIVRL 74 +GEG A+V+ N T A+KI+ K + ++ RE+ ++ + H N++ L Sbjct: 20 VLGEGAHARVQTCINLITSQEYAVKIIEKQP---GHIRSRVFREVEMLYQCQGHRNVLEL 76 Query: 75 YEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRD 134 E + Y+V E + GG + I + E E+ Q + A+ H KG+ HRD Sbjct: 77 IEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHNKGIAHRD 136 Query: 135 LKPENLLLDTNGN---LKVSDFGLSA--------LPQEGVELLRTTCGTPNYVAPEVLSG 183 LKPEN+L + +K+ DFGL + P ELL T CG+ Y+APEV+ Sbjct: 137 LKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPELL-TPCGSAEYMAPEVVEA 195 Query: 184 QGYDGSA----ADIWSCGVILFVILAGYLPF---SETD--------LPG----LYRKINA 224 + S D+WS GVIL+++L+GY PF +D P L+ I Sbjct: 196 FSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQNMLFESIQE 255 Query: 225 AEFSCP--PW--FSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFR 265 ++ P W S K LI ++L + K R+ + + PW + Sbjct: 256 GKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQ 300 >2VD5-A nrPDB Length = 412 Score = 105 bits (261), Expect = 5e-23, Method: Compositional matrix adjust. Identities = 80/270 (29%), Positives = 127/270 (47%), Gaps = 17/270 (6%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 +E+ + IG G F++V + TG A+KIM K +LK V + E ++ Sbjct: 63 FEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDRRW 122 Query: 71 IVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKG-RLEESESRKYFQQLVDAVAHCHCKG 129 I +L+ + +Y+V+E+ GG+L + G R+ +R Y ++V A+ H G Sbjct: 123 ITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHRLG 182 Query: 130 VYHRDLKPENLLLDTNGNLKVSDFGLS-ALPQEGVELLRTTCGTPNYVAPEVLSG----- 183 HRD+KP+N+LLD G+++++DFG L +G GTP+Y++PE+L Sbjct: 183 YVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAVGGGP 242 Query: 184 -QGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKI--NAAEFSCP---PWFSAEV 237 G G D W+ GV + + G PF Y KI S P E Sbjct: 243 GTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDEGVPEEA 302 Query: 238 KFLIHRILDPNPKTRIQIQG---IKKDPWF 264 + I R+L P P+TR+ G + P+F Sbjct: 303 RDFIQRLLCP-PETRLGRGGAGDFRTHPFF 331 >4AGU-A nrPDB Length = 311 Score = 105 bits (261), Expect = 5e-23, Method: Compositional matrix adjust. Identities = 65/207 (31%), Positives = 106/207 (51%), Gaps = 9/207 (4%) Query: 1 MTKKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIK-RE 59 M +K ++GK IGEG++ V RN DTG VAIK +S + ++ +I RE Sbjct: 1 MMEKYEKIGK------IGEGSYGVVFKCRNRDTGQIVAIKKFLESE--DDPVIKKIALRE 52 Query: 60 ISIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLV 119 I ++K ++HPN+V L EV ++++V E+ L + ++ + E + Q + Sbjct: 53 IRMLKQLKHPNLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTL 112 Query: 120 DAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPE 179 AV CH HRD+KPEN+L+ + +K+ DFG + L + T Y +PE Sbjct: 113 QAVNFCHKHNCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYDDEVATRWYRSPE 172 Query: 180 VLSGQGYDGSAADIWSCGVILFVILAG 206 +L G G D+W+ G + +L+G Sbjct: 173 LLVGDTQYGPPVDVWAIGCVFAELLSG 199 >5DBX-A nrPDB Length = 328 Score = 103 bits (258), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 67/214 (31%), Positives = 112/214 (52%), Gaps = 17/214 (7%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 YE+ IG G A V+ A + VAIK + + +D++ +EI M HPN Sbjct: 13 YELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTS--MDELLKEIQAMSQCSHPN 70 Query: 71 IVRLYEVLASPSKIYIVLEFVTGGELFD-------RIVHK-GRLEESESRKYFQQLVDAV 122 +V Y ++++V++ ++GG + D R HK G LEE+ +++++ + Sbjct: 71 VVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGL 130 Query: 123 AHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTT-----CGTPNYVA 177 + H G HRDLK N+LL +G+++++DFG+SA G ++ R GTP ++A Sbjct: 131 DYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKDFVGTPCWMA 190 Query: 178 PEVLSG-QGYDGSAADIWSCGVILFVILAGYLPF 210 PEV+ +GYD AD+WS G+ + G P+ Sbjct: 191 PEVMEQVRGYD-FKADMWSFGITAIELATGAAPY 223 >1ZXE-A nrPDB Length = 303 Score = 103 bits (257), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 75/306 (24%), Positives = 141/306 (46%), Gaps = 47/306 (15%) Query: 5 MRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMK 64 +R +E +G+G F +V ARN AIK + + + I E+ ++ Sbjct: 2 LRYASDFEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRHT----EEKLSTILSEVMLLA 57 Query: 65 IVRHPNIVRLYEV-------------LASPSKIYIVLEFVTGGELFDRIVHKGRLEES-- 109 + H +VR Y + S ++I +E+ L+D ++H L + Sbjct: 58 SLNHQYVVRYYAAWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYD-LIHSENLNQQRD 116 Query: 110 ESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLR-- 167 E + F+Q+++A+++ H +G+ HR+LKP N+ +D + N+K+ DFGL+ +++L+ Sbjct: 117 EYWRLFRQILEALSYIHSQGIIHRNLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLD 176 Query: 168 ------------TTCGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSE-TD 214 + GT YVA EVL G G+ D++S G+I F ++ PFS + Sbjct: 177 SQNLPGSSDNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMI---YPFSTGME 233 Query: 215 LPGLYRKINAAEFSCPPWFSAEV----KFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVP 270 + +K+ + PP F K +I ++D +P R + + W +P Sbjct: 234 RVNILKKLRSVSIEFPPDFDDNKMKVEKKIIRLLIDHDPNKRPGARTLLNSGW-----LP 288 Query: 271 IRAREE 276 ++ ++E Sbjct: 289 VKHQDE 294 >6AO5-A nrPDB Length = 362 Score = 102 bits (253), Expect = 5e-22, Method: Compositional matrix adjust. Identities = 77/283 (27%), Positives = 139/283 (49%), Gaps = 29/283 (10%) Query: 1 MTKKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREI 60 +TK+ V ++V +GEG++ V A + ++G VAIK + + L+ +I +EI Sbjct: 4 LTKQPEEV--FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQ-----EIIKEI 56 Query: 61 SIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGR-LEESESRKYFQQLV 119 SIM+ P +V+ Y + ++IV+E+ G + D I + + L E E + + Sbjct: 57 SIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTL 116 Query: 120 DAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPE 179 + + H HR++K N+LL+T G+ K++DFG++ + + T GTP ++APE Sbjct: 117 KGLEYLHFMRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPE 176 Query: 180 VLSGQGYDGSAADIWSCGVILFVILAGYLPFSE-----------TDLPGLYRKINAAEFS 228 V+ GY+ ADIWS G+ + G P+++ T+ P +RK Sbjct: 177 VIQEIGYN-CVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRK------- 228 Query: 229 CPPWFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVPI 271 P +S + + + L NP+ R + + P+ + N P+ Sbjct: 229 -PELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIK-NAKPV 269 >4LG4-A nrPDB Length = 299 Score = 101 bits (251), Expect = 7e-22, Method: Compositional matrix adjust. Identities = 75/277 (27%), Positives = 136/277 (49%), Gaps = 28/277 (10%) Query: 1 MTKKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREI 60 +TK+ V ++V +GEG++ V A + ++G VAIK + + L+ +I +EI Sbjct: 5 LTKQPEEV--FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQ-----EIIKEI 57 Query: 61 SIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGR-LEESESRKYFQQLV 119 SIM+ P +V+ Y + ++IV+E+ G + D I + + L E E + + Sbjct: 58 SIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTL 117 Query: 120 DAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPE 179 + + H HR++K N+LL+T G+ K++DFG++ + + T GTP ++APE Sbjct: 118 KGLEYLHFMRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPE 177 Query: 180 VLSGQGYDGSAADIWSCGVILFVILAGYLPFSE-----------TDLPGLYRKINAAEFS 228 V+ GY+ ADIWS G+ + G P+++ T+ P +RK Sbjct: 178 VIQEIGYN-CVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRK------- 229 Query: 229 CPPWFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFR 265 P +S + + + L NP+ R + + P+ + Sbjct: 230 -PELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIK 265 >5EFQ-A nrPDB Length = 347 Score = 100 bits (249), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 67/209 (32%), Positives = 108/209 (51%), Gaps = 18/209 (8%) Query: 6 RRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKI 65 R V K+++ IGEGT+ +V AR+ DTG+ VA+K + + + I REI I++ Sbjct: 8 RCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAI-REIKILRQ 66 Query: 66 VRHPNIVRLYEVLASPSK----------IYIVLEFVTG---GELFDRIVHKGRLEESESR 112 + H +I+ + E++ Y+V E++ G L +VH E+ + Sbjct: 67 LTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVH---FNENHIK 123 Query: 113 KYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSAL-PQEGVELLRTTCG 171 + +QL++ + +CH K HRD+K N+LL+ G +K++DFGL+ L E Sbjct: 124 SFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVI 183 Query: 172 TPNYVAPEVLSGQGYDGSAADIWSCGVIL 200 T Y PE+L G+ A D+WSCG IL Sbjct: 184 TLWYRPPELLLGEERYTPAIDVWSCGCIL 212 >1UA2-A nrPDB Length = 346 Score = 100 bits (248), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 75/231 (32%), Positives = 111/231 (48%), Gaps = 31/231 (13%) Query: 7 RVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKI--MAKSTILKNRMVDQIKREISIMK 64 R +YE +GEG FA V AR+ +T VAIK + + K+ + REI +++ Sbjct: 8 RAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQ 67 Query: 65 IVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRL--EESESRKYFQQLVDAV 122 + HPNI+ L + S I +V +F+ + I+ L S + Y + + Sbjct: 68 ELSHPNIIGLLDAFGHKSNISLVFDFMETD--LEVIIKDNSLVLTPSHIKAYMLMTLQGL 125 Query: 123 AHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPN-------- 174 + H + HRDLKP NLLLD NG LK++DFGL+ + G+PN Sbjct: 126 EYLHQHWILHRDLKPNNLLLDENGVLKLADFGLA-----------KSFGSPNRAYTHQVV 174 Query: 175 ---YVAPEVLSGQGYDGSAADIWSCGVILFVIL--AGYLPFSETDLPGLYR 220 Y APE+L G G D+W+ G IL +L +LP ++DL L R Sbjct: 175 TRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLP-GDSDLDQLTR 224 >4BGQ-A nrPDB Length = 304 Score = 99.8 bits (247), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 68/197 (34%), Positives = 103/197 (52%), Gaps = 9/197 (4%) Query: 8 VGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIK-REISIMKIV 66 + K+E+ +GEG + V R+ +T + VAIK S +N V + RE+ +++ + Sbjct: 11 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSE--ENEEVKETTLRELKMLRTL 68 Query: 67 RHPNIVRLYEVLASPSKIYIVLEFVTGG--ELFDRIVHKGRLEESESRKYFQQLVDAVAH 124 + NIV L E K+Y+V E+V EL + + + E+ +S Y QL+ A+ Sbjct: 69 KQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKS--YIYQLIKAIHW 126 Query: 125 CHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVEL-LRTTCGTPNYVAPEVLSG 183 CH + HRD+KPENLL+ N LK+ DFG + EG T Y +PE+L G Sbjct: 127 CHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYDEEVATRWYRSPELLLG 186 Query: 184 QGYDGSAADIWSCGVIL 200 Y G + D+WS G IL Sbjct: 187 APY-GKSVDMWSVGCIL 202 >4QMW-A nrPDB Length = 310 Score = 99.8 bits (247), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 59/196 (30%), Positives = 103/196 (52%), Gaps = 4/196 (2%) Query: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYE 76 IG+G+F +V + T VAIKI+ Q +EI+++ P + + Y Sbjct: 37 IGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQ--QEITVLSQCDSPYVTKYYG 94 Query: 77 VLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDLK 136 +K++I++E++ GG D ++ G L+E++ ++++ + + H + HRD+K Sbjct: 95 SYLKDTKLWIIMEYLGGGSALD-LLEPGPLDETQIATILREILKGLDYLHSEKKIHRDIK 153 Query: 137 PENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSAADIWSC 196 N+LL +G +K++DFG++ + T GTP ++APEV+ YD S ADIWS Sbjct: 154 AANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYD-SKADIWSL 212 Query: 197 GVILFVILAGYLPFSE 212 G+ + G P SE Sbjct: 213 GITAIELARGEPPHSE 228 >6E2O-A nrPDB Length = 295 Score = 99.0 bits (245), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 78/264 (29%), Positives = 129/264 (48%), Gaps = 21/264 (7%) Query: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYE 76 +G+GT+ V R+ +AIK + + +R + EI++ K ++H NIV+ Sbjct: 30 LGKGTYGIVYAGRDLSNQVRIAIKEIPERD---SRYSQPLHEEIALHKHLKHKNIVQYLG 86 Query: 77 VLASPSKIYIVLEFVTGGELFDRIVHK-GRLEESESRK--YFQQLVDAVAHCHCKGVYHR 133 + I I +E V GG L + K G L+++E Y +Q+++ + + H + HR Sbjct: 87 SFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHR 146 Query: 134 DLKPENLLLDT-NGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSG--QGYDGSA 190 D+K +N+L++T +G LK+SDFG S T GT Y+APE++ +GY G A Sbjct: 147 DIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGY-GKA 205 Query: 191 ADIWSCGVILFVILAGYLPFSETDLP-------GLYRKINAAEFSCPPWFSAEVKFLIHR 243 ADIWS G + + G PF E P G+++ P SAE K I + Sbjct: 206 ADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFK----VHPEIPESMSAEAKAFILK 261 Query: 244 ILDPNPKTRIQIQGIKKDPWFRLN 267 +P+P R + D + +++ Sbjct: 262 CFEPDPDKRACANDLLVDEFLKVS 285 >6CQF-A nrPDB Length = 297 Score = 99.0 bits (245), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 63/192 (32%), Positives = 106/192 (55%), Gaps = 9/192 (4%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 Y++ + +G GT+ +V AR+ +GD VA+K++ + V +++EI I+K RH N Sbjct: 18 YDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEP---DDDVSTLQKEILILKTCRHAN 74 Query: 71 IVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGV 130 IV + K++I +EF G L D G L E + ++++ +A+ H + Sbjct: 75 IVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSQKK 134 Query: 131 YHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTC--GTPNYVAPEV--LSGQGY 186 HRD+K N+L++ G ++++DFG+SA Q G L R GTP ++APEV ++ +G Sbjct: 135 IHRDIKGANILINDAGEVRLADFGISA--QIGATLARRLAFIGTPYWMAPEVAAVALKGG 192 Query: 187 DGSAADIWSCGV 198 DIWS G+ Sbjct: 193 YNELCDIWSLGI 204 >5L2Q-C nrPDB Length = 320 Score = 97.8 bits (242), Expect = 8e-21, Method: Compositional matrix adjust. Identities = 61/185 (32%), Positives = 103/185 (55%), Gaps = 15/185 (8%) Query: 83 KIYIVLEFVTGGELFDR----------IVHKGRLEESESRKYFQQLVDAVAHCHCKGVYH 132 +I +VL+ + + D+ ++ + RL E E+ F +V V H K + H Sbjct: 117 RICLVLDCLCAHDFSDKTADLINLQHYVIKEKRLSERETVVIFYDVVRVVEALHQKNIVH 176 Query: 133 RDLKPENLLLDTNGN-LKVSDFGLSA-LPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSA 190 RDLK N++L+ + + +++F L L EG +LL+ G+P Y++P+VLSG+ Y G Sbjct: 177 RDLKLGNMVLNKRTHRITITNFCLGKHLVSEG-DLLKDQRGSPAYISPDVLSGRPYRGKP 235 Query: 191 ADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPP--WFSAEVKFLIHRILDPN 248 +D+W+ GV+LF +L G PF ++ L+RKI AAE++ P S LI ++L + Sbjct: 236 SDMWALGVVLFTMLYGQFPFYDSIPQELFRKIKAAEYTIPEDGRVSENTVCLIRKLLVLD 295 Query: 249 PKTRI 253 P+ R+ Sbjct: 296 PQQRL 300 >4NST-A nrPDB Length = 351 Score = 97.8 bits (242), Expect = 8e-21, Method: Compositional matrix adjust. Identities = 66/209 (31%), Positives = 108/209 (51%), Gaps = 18/209 (8%) Query: 6 RRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKI 65 R V K+++ IGEGT+ +V A++ DTG+ VA+K + + + I REI I++ Sbjct: 10 RCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAI-REIKILRQ 68 Query: 66 VRHPNIVRLYEVLASPSK----------IYIVLEFVTG---GELFDRIVHKGRLEESESR 112 + H ++V + E++ Y+V E++ G L +VH E + Sbjct: 69 LIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVH---FSEDHIK 125 Query: 113 KYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSAL-PQEGVELLRTTCG 171 + +QL++ + +CH K HRD+K N+LL+ +G +K++DFGL+ L E Sbjct: 126 SFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVI 185 Query: 172 TPNYVAPEVLSGQGYDGSAADIWSCGVIL 200 T Y PE+L G+ A D+WSCG IL Sbjct: 186 TLWYRPPELLLGEERYTPAIDVWSCGCIL 214 >2XIK-A nrPDB Length = 294 Score = 97.8 bits (242), Expect = 9e-21, Method: Compositional matrix adjust. Identities = 59/196 (30%), Positives = 102/196 (52%), Gaps = 4/196 (2%) Query: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYE 76 IG+G+F +V + T + VAIKI+ Q +EI+++ P I R + Sbjct: 27 IGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQ--QEITVLSQCDSPYITRYFG 84 Query: 77 VLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDLK 136 +K++I++E++ GG D ++ G LEE+ ++++ + + H + HRD+K Sbjct: 85 SYLKSTKLWIIMEYLGGGSALD-LLKPGPLEETYIATILREILKGLDYLHSERKIHRDIK 143 Query: 137 PENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSAADIWSC 196 N+LL G++K++DFG++ + T GTP ++APEV+ YD ADIWS Sbjct: 144 AANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYD-FKADIWSL 202 Query: 197 GVILFVILAGYLPFSE 212 G+ + G P S+ Sbjct: 203 GITAIELAKGEPPNSD 218 >3C51-A nrPDB Length = 543 Score = 97.8 bits (242), Expect = 9e-21, Method: Compositional matrix adjust. Identities = 74/264 (28%), Positives = 126/264 (47%), Gaps = 14/264 (5%) Query: 15 RTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRL 74 R +G G F +V + TG A K + K + K + E I+ V IV L Sbjct: 191 RVLGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILAKVHSRFIVSL 250 Query: 75 YEVLASPSKIYIVLEFVTGGELFDRIVHKGR----LEESESRKYFQQLVDAVAHCHCKGV 130 + + + +V+ + GG++ I + +E + Y Q+V + H H + + Sbjct: 251 AYAFETKTDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQIVSGLEHLHQRNI 310 Query: 131 YHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSA 190 +RDLKPEN+LLD +GN+++SD GL+ + G + GTP ++APE+L G+ YD S Sbjct: 311 IYRDLKPENVLLDDDGNVRISDLGLAVELKAGQTKTKGYAGTPGFMAPELLLGEEYDFS- 369 Query: 191 ADIWSCGVILFVILAGYLPF----SETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILD 246 D ++ GV L+ ++A PF + + L +++ + P FS K +L Sbjct: 370 VDYFALGVTLYEMIAARGPFRARGEKVENKELKQRVLEQAVTYPDKFSPASKDFCEALLQ 429 Query: 247 PNPKTRI-----QIQGIKKDPWFR 265 +P+ R+ G++ P FR Sbjct: 430 KDPEKRLGFRDGSCDGLRTHPLFR 453 >1U5R-A nrPDB Length = 348 Score = 97.4 bits (241), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 61/188 (32%), Positives = 95/188 (50%), Gaps = 10/188 (5%) Query: 15 RTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRL 74 R IG G+F V FAR+ + VAIK M+ S N I +E+ ++ +RHPN ++ Sbjct: 60 REIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPNTIQY 119 Query: 75 YEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRD 134 ++V+E+ G VHK L+E E + +A+ H + HRD Sbjct: 120 RGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHSHNMIHRD 179 Query: 135 LKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVL----SGQGYDGSA 190 +K N+LL G +K+ DFG +++ + + GTP ++APEV+ GQ YDG Sbjct: 180 VKAGNILLSEPGLVKLGDFGSASI----MAPANSFVGTPYWMAPEVILAMDEGQ-YDGK- 233 Query: 191 ADIWSCGV 198 D+WS G+ Sbjct: 234 VDVWSLGI 241 >2GCD-A nrPDB Length = 309 Score = 97.1 bits (240), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 61/188 (32%), Positives = 95/188 (50%), Gaps = 10/188 (5%) Query: 15 RTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRL 74 R IG G+F V FAR+ + VAIK M+ S N I +E+ ++ +RHPN ++ Sbjct: 21 REIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPNTIQY 80 Query: 75 YEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRD 134 ++V+E+ G VHK L+E E + +A+ H + HRD Sbjct: 81 RGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHSHNMIHRD 140 Query: 135 LKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVL----SGQGYDGSA 190 +K N+LL G +K+ DFG +++ + + GTP ++APEV+ GQ YDG Sbjct: 141 VKAGNILLSEPGLVKLGDFGSASI----MAPANSFVGTPYWMAPEVILAMDEGQ-YDGK- 194 Query: 191 ADIWSCGV 198 D+WS G+ Sbjct: 195 VDVWSLGI 202 >6DTL-A nrPDB Length = 364 Score = 96.7 bits (239), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 61/194 (31%), Positives = 102/194 (52%), Gaps = 10/194 (5%) Query: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRM-VDQIKREISIMKIVRHPNIVRLY 75 IG+G + V A N++T ++VAIK +A + N++ + REI +++ + H NIV + Sbjct: 38 IGKGAYGIVCSAMNSETNESVAIKKIANA--FDNKIDAKRTLREIKLLRHMDHENIVAIR 95 Query: 76 EVLASP-----SKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGV 130 +++ P + +YI E + +L I L E + + Q++ + + H V Sbjct: 96 DIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANV 154 Query: 131 YHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSA 190 HRDLKP NLLL+ N +LK+ DFGL+ + E + + T Y APE+L +A Sbjct: 155 LHRDLKPSNLLLNANCDLKICDFGLARVTSES-DFMTEYVVTRWYRAPELLLNSSDYTAA 213 Query: 191 ADIWSCGVILFVIL 204 D+WS G I ++ Sbjct: 214 IDVWSVGCIFMELM 227 >4OW8-A nrPDB Length = 283 Score = 95.9 bits (237), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 72/257 (28%), Positives = 118/257 (45%), Gaps = 10/257 (3%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 G+Y + R I G +V A + G VA+K++ +++ + E ++ H Sbjct: 11 GRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNH 70 Query: 69 PNIVRLYEVLASP-----SKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVA 123 P I +++ S Y+V+E V G L + GRL + +Q A+ Sbjct: 71 PGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQ 130 Query: 124 HCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLS-ALPQEGVELLRTTCGTPNYVAPEVLS 182 H G+ HRD+KP N+L+ G +K++DFG++ A+ V GT Y+APE Sbjct: 131 IAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPE--Q 188 Query: 183 GQGYDGS-AADIWSCGVILFVILAGYLPFS-ETDLPGLYRKINAAEFSCPPWFSAEVKFL 240 G+D S A+D++S GV+ + ++G PF+ + L + I PP V+ L Sbjct: 189 ALGHDASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKEPPPPLPPDLPPNVREL 248 Query: 241 IHRILDPNPKTRIQIQG 257 I L NP R + G Sbjct: 249 IEITLVKNPAMRYRSGG 265 >4ZSG-A nrPDB Length = 347 Score = 95.5 bits (236), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 67/208 (32%), Positives = 101/208 (48%), Gaps = 16/208 (7%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKS-TILKNRMVDQIKREISIMKIVRH 68 +YE+ TIG G + V AR TG VAIK + + ++ N + RE+ I+K +H Sbjct: 8 EYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTN--AKRTLRELKILKHFKH 65 Query: 69 PNIVRLYEVLASP------SKIYIVLEFVTGGELFDRIVHKGRLEESESRKYF-QQLVDA 121 NI+ + ++L +Y+VL+ + +I+H + E +YF QL+ Sbjct: 66 DNIIAIKDILRPTVPYGEFKSVYVVLDLMESD--LHQIIHSSQPLTLEHVRYFLYQLLRG 123 Query: 122 VAHCHCKGVYHRDLKPENLLLDTNGNLKVSDF----GLSALPQEGVELLRTTCGTPNYVA 177 + + H V HRDLKP NLL++ N LK+ DF GL P E + T Y A Sbjct: 124 LKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRA 183 Query: 178 PEVLSGQGYDGSAADIWSCGVILFVILA 205 PE++ A D+WS G I +LA Sbjct: 184 PELMLSLHEYTQAIDLWSVGCIFGEMLA 211 >4U41-A nrPDB Length = 332 Score = 95.5 bits (236), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 67/219 (30%), Positives = 110/219 (50%), Gaps = 19/219 (8%) Query: 8 VGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMK-IV 66 G +E+ +G GT+ +V R+ TG AIK+M + ++IK EI+++K Sbjct: 23 AGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMD----VTEDEEEEIKLEINMLKKYS 78 Query: 67 RHPNIVRLYEVLASPS------KIYIVLEFVTGGELFDRIVH-KGRLEESESRKYF-QQL 118 H NI Y S ++++V+EF G + D + + KG + + Y +++ Sbjct: 79 HHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREI 138 Query: 119 VDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAP 178 + +AH H V HRD+K +N+LL N +K+ DFG+SA V T GTP ++AP Sbjct: 139 LRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 198 Query: 179 EVLS-----GQGYDGSAADIWSCGVILFVILAGYLPFSE 212 EV++ YD +D+WSCG+ + G P + Sbjct: 199 EVIACDENPDATYD-YRSDLWSCGITAIEMAEGAPPLCD 236 >6B2Q-A nrPDB Length = 317 Score = 95.5 bits (236), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 72/257 (28%), Positives = 118/257 (45%), Gaps = 10/257 (3%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 G+Y + R I G +V A + G VA+K++ +++ + E ++ H Sbjct: 32 GRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNH 91 Query: 69 PNIVRLYEVLASP-----SKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVA 123 P I +++ S Y+V+E V G L + GRL + +Q A+ Sbjct: 92 PGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQ 151 Query: 124 HCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLS-ALPQEGVELLRTTCGTPNYVAPEVLS 182 H G+ HRD+KP N+L+ G +K++DFG++ A+ V GT Y+APE Sbjct: 152 IAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPE--Q 209 Query: 183 GQGYDGS-AADIWSCGVILFVILAGYLPFS-ETDLPGLYRKINAAEFSCPPWFSAEVKFL 240 G+D S A+D++S GV+ + ++G PF+ + L + I PP V+ L Sbjct: 210 ALGHDASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKEPPPPLPPDLPPNVREL 269 Query: 241 IHRILDPNPKTRIQIQG 257 I L NP R + G Sbjct: 270 IEITLVKNPAMRYRSGG 286 >4X3F-A nrPDB Length = 337 Score = 95.5 bits (236), Expect = 5e-20, Method: Compositional matrix adjust. Identities = 72/257 (28%), Positives = 118/257 (45%), Gaps = 10/257 (3%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 G+Y + R I G +V A + G VA+K++ +++ + E ++ H Sbjct: 12 GRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNH 71 Query: 69 PNIVRLYEVLASP-----SKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVA 123 P I +++ S Y+V+E V G L + GRL + +Q A+ Sbjct: 72 PGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQ 131 Query: 124 HCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLS-ALPQEGVELLRTTCGTPNYVAPEVLS 182 H G+ HRD+KP N+L+ G +K++DFG++ A+ V GT Y+APE Sbjct: 132 IAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPE--Q 189 Query: 183 GQGYDGS-AADIWSCGVILFVILAGYLPFS-ETDLPGLYRKINAAEFSCPPWFSAEVKFL 240 G+D S A+D++S GV+ + ++G PF+ + L + I PP V+ L Sbjct: 190 ALGHDASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKEPPPPLPPDLPPNVREL 249 Query: 241 IHRILDPNPKTRIQIQG 257 I L NP R + G Sbjct: 250 IEITLVKNPAMRYRSGG 266 >3E7O-A nrPDB Length = 360 Score = 94.7 bits (234), Expect = 7e-20, Method: Compositional matrix adjust. Identities = 68/221 (30%), Positives = 111/221 (50%), Gaps = 16/221 (7%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRM-VDQIKREISIMKIVRH 68 +Y+ + IG G V A +T G NVA+K +++ +N+ + RE+ ++K V H Sbjct: 23 RYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP--FQNQTHAKRAYRELVLLKCVNH 80 Query: 69 PNIVRLYEVLASPSK-------IYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDA 121 NI+ L V +P K +Y+V+E + +++H E S +Q L Sbjct: 81 KNIISLLNVF-TPQKTLEEFQDVYLVMELMDAN--LCQVIHMELDHERMSYLLYQMLC-G 136 Query: 122 VAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVL 181 + H H G+ HRDLKP N+++ ++ LK+ DFGL+ ++ T Y APEV+ Sbjct: 137 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTASTNF-MMTPYVVTRYYRAPEVI 195 Query: 182 SGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKI 222 G GY + DIWS G I+ ++ G + F TD + K+ Sbjct: 196 LGMGYKEN-VDIWSVGCIMGELVKGSVIFQGTDHIDQWNKV 235 >4IC8-A nrPDB Length = 442 Score = 94.4 bits (233), Expect = 8e-20, Method: Compositional matrix adjust. Identities = 67/208 (32%), Positives = 101/208 (48%), Gaps = 16/208 (7%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKS-TILKNRMVDQIKREISIMKIVRH 68 +YE+ TIG G + V AR TG VAIK + + ++ N + RE+ I+K +H Sbjct: 56 EYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTN--AKRTLRELKILKHFKH 113 Query: 69 PNIVRLYEVLASP------SKIYIVLEFVTGGELFDRIVHKGRLEESESRKYF-QQLVDA 121 NI+ + ++L +Y+VL+ + +I+H + E +YF QL+ Sbjct: 114 DNIIAIKDILRPTVPYGEFKSVYVVLDLMESD--LHQIIHSSQPLTLEHVRYFLYQLLRG 171 Query: 122 VAHCHCKGVYHRDLKPENLLLDTNGNLKVSDF----GLSALPQEGVELLRTTCGTPNYVA 177 + + H V HRDLKP NLL++ N LK+ DF GL P E + T Y A Sbjct: 172 LKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRA 231 Query: 178 PEVLSGQGYDGSAADIWSCGVILFVILA 205 PE++ A D+WS G I +LA Sbjct: 232 PELMLSLHEYTQAIDLWSVGCIFGEMLA 259 >3QA8-A nrPDB Length = 676 Score = 93.6 bits (231), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 69/215 (32%), Positives = 102/215 (47%), Gaps = 16/215 (7%) Query: 8 VGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR 67 G +E+ +G G F V + DTG+ VAIK + KNR ++ EI IMK + Sbjct: 13 CGPWEMKERLGTGGFGYVLRWIHQDTGEQVAIKQCRQELSPKNR--ERWCLEIQIMKKLN 70 Query: 68 HPNIVRLYEV------LASPSKIYIVLEFVTGGEL---FDRIVHKGRLEESESRKYFQQL 118 HPN+V EV LA + +E+ GG+L ++ + L+E R + Sbjct: 71 HPNVVSAREVPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGPIRTLLSDI 130 Query: 119 VDAVAHCHCKGVYHRDLKPENLLLDTNGNL---KVSDFGLSALPQEGVELLRTTCGTPNY 175 A+ + H + HRDLKPEN++L K+ D G + +G EL GT Y Sbjct: 131 SSALRYLHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQG-ELCTEFVGTLQY 189 Query: 176 VAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPF 210 +APE+L + Y D WS G + F + G+ PF Sbjct: 190 LAPELLEQKKYT-VTVDYWSFGTLAFECITGFRPF 223 >3NYO-A nrPDB Length = 576 Score = 93.6 bits (231), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 82/289 (28%), Positives = 144/289 (49%), Gaps = 20/289 (6%) Query: 15 RTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRL 74 R +G+G F +V + TG A K + K I K + E I++ V +V L Sbjct: 190 RVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSL 249 Query: 75 YEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYF--QQLVDAVAHCHCKGVYH 132 + + +VL + GG+L I H G+ E+R F ++ + H + + + Sbjct: 250 AYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVY 309 Query: 133 RDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSAAD 192 RDLKPEN+LLD +G++++SD GL+ EG + ++ GT Y+APEV+ + Y S D Sbjct: 310 RDLKPENILLDDHGHIRISDLGLAVHVPEG-QTIKGRVGTVGYMAPEVVKNERYTFS-PD 367 Query: 193 IWSCGVILFVILAGYLPFSE-------TDLPGLYRKINAAEFSCPPWFSAEVKFLIHRIL 245 W+ G +L+ ++AG PF + ++ L +++ E+S FS + + L ++L Sbjct: 368 WWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEV-PEEYS--ERFSPQARSLCSQLL 424 Query: 246 DPNPKTRIQIQG-----IKKDPWF-RLNYVPIRAREEEEVNLDDIRAVF 288 +P R+ +G +K+ P F +LN+ + A E D +A++ Sbjct: 425 CKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIY 473 >2F9G-A nrPDB Length = 353 Score = 93.2 bits (230), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 65/205 (31%), Positives = 98/205 (47%), Gaps = 19/205 (9%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 +++ +GEG + V A + TG+ VAIK + K + REI I+K +H N Sbjct: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI--EPFDKPLFALRTLREIKILKHFKHEN 70 Query: 71 IVRLYEVLASPS-----KIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHC 125 I+ ++ + S ++YI+ E + R++ L + + + Q + AV Sbjct: 71 IITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVKVL 128 Query: 126 HCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGV----ELLRTTCGTPNYV----- 176 H V HRDLKP NLL+++N +LKV DFGL+ + E E G YV Sbjct: 129 HGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWY 188 Query: 177 -APEVLSGQGYDGSAADIWSCGVIL 200 APEV+ A D+WSCG IL Sbjct: 189 RAPEVMLTSAKYSRAMDVWSCGCIL 213 >5TQX-A nrPDB Length = 655 Score = 93.2 bits (230), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 80/281 (28%), Positives = 133/281 (47%), Gaps = 28/281 (9%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 G +E+ +G G F V ++ + +AIK KNR ++ EI IMK + H Sbjct: 8 GPWEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNR--ERWCHEIQIMKKLNH 65 Query: 69 PNIVRLYEVLASPSKIYIV--------LEFVTGGEL---FDRIVHKGRLEESESRKYFQQ 117 N+V+ +V P ++ I+ +E+ +GG+L ++ + L+ES+ Sbjct: 66 ANVVKACDV---PEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSD 122 Query: 118 LVDAVAHCHCKGVYHRDLKPENLLL-DTNGNL--KVSDFGLSALPQEGVELLRTTCGTPN 174 + + + H + HRDLKPEN++L D G + K+ D G + +G EL GT Sbjct: 123 IGSGIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQG-ELCTEFVGTLQ 181 Query: 175 YVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLP-GLYRKINAAE----FSC 229 Y+APE+ + Y + D WS G ++F +AGY PF P + KI + F+C Sbjct: 182 YLAPELFENKPYTAT-VDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPKCIFAC 240 Query: 230 PPWFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVP 270 S EV+F H + PN + ++ ++ LN+ P Sbjct: 241 EE-MSGEVRFSSH-LPQPNSLCSLIVEPMENWLQLMLNWDP 279 >5H2U-A nrPDB Length = 267 Score = 92.8 bits (229), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 66/230 (28%), Positives = 114/230 (49%), Gaps = 13/230 (5%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 ++ + R +G G F +V F VAIK++++ +L +M ++ EI MK +RH Sbjct: 7 EFTLCRKLGSGYFGEV-FEGLWKDRVQVAIKVISRDNLLHQQM---LQSEIQAMKKLRHK 62 Query: 70 NIVRLYEVLASPSKIYIVLEFVTGGELFD--RIVHKGRLEESESRKYFQQLVDAVAHCHC 127 +I+ LY V++ +YI+ E + G L + R + L SE Q+ + + + Sbjct: 63 HILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLES 122 Query: 128 KGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYD 187 + HRDL N+L+ N KV DFGL+ L +E V L + APE LS +G+ Sbjct: 123 QNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALS-RGHY 181 Query: 188 GSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINA-----AEFSCPP 231 + +D+WS G++L + + G +P+ + +++A CPP Sbjct: 182 STKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPP 231 >5D7A-A nrPDB Length = 308 Score = 92.4 bits (228), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 65/218 (29%), Positives = 111/218 (50%), Gaps = 17/218 (7%) Query: 8 VGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMK-IV 66 G +E+ +G GT+ +V R+ TG AIK+M + ++IK+EI+++K Sbjct: 16 AGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMD----VTGDEEEEIKQEINMLKKYS 71 Query: 67 RHPNIVRLYEVLASPS------KIYIVLEFVTGGELFDRIVH-KGRLEESESRKYF-QQL 118 H NI Y + ++++V+EF G + D I + KG + E Y +++ Sbjct: 72 HHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREI 131 Query: 119 VDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAP 178 + ++H H V HRD+K +N+LL N +K+ DFG+SA V T GTP ++AP Sbjct: 132 LRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 191 Query: 179 EVLS-GQGYDGS---AADIWSCGVILFVILAGYLPFSE 212 EV++ + D + +D+WS G+ + G P + Sbjct: 192 EVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCD 229 >4FZF-B nrPDB Length = 283 Score = 90.9 bits (224), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 56/196 (28%), Positives = 99/196 (50%), Gaps = 4/196 (2%) Query: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYE 76 IG+G+F +V + T VAIKI+ Q +EI+++ + + Y Sbjct: 16 IGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQ--QEITVLSQCDSSYVTKYYG 73 Query: 77 VLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDLK 136 SK++I++E++ GG D ++ G +E + ++++ + + H + HRD+K Sbjct: 74 SYLKGSKLWIIMEYLGGGSALD-LLRAGPFDEFQIATMLKEILKGLDYLHSEKKIHRDIK 132 Query: 137 PENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSAADIWSC 196 N+LL G++K++ FG++ + T GTP ++APEV+ YD S ADIWS Sbjct: 133 AANVLLSEQGDVKLAAFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYD-SKADIWSL 191 Query: 197 GVILFVILAGYLPFSE 212 G+ + G P S+ Sbjct: 192 GITAIELAKGEPPNSD 207 >4E7W-A nrPDB Length = 394 Score = 90.9 bits (224), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 67/207 (32%), Positives = 107/207 (51%), Gaps = 21/207 (10%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 Y + IG G+F V A+ ++ D VAIK + + KNR E+ IM+IV+HPN Sbjct: 42 YTNCKVIGNGSFGVVFQAKLVES-DEVAIKKVLQDKRFKNR-------ELQIMRIVKHPN 93 Query: 71 IVRLYEVLASPSK------IYIVLEFVTGGELFDRIVHKGRLEESES----RKYFQQLVD 120 +V L S + +VLE+V ++ H +L+++ + Y QL+ Sbjct: 94 VVDLKAFFYSNGDKKDEVFLNLVLEYVPE-TVYRASRHYAKLKQTMPMLLIKLYMYQLLR 152 Query: 121 AVAHCHCKGVYHRDLKPENLLLD-TNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPE 179 ++A+ H G+ HRD+KP+NLLLD +G LK+ DFG + + G + C Y APE Sbjct: 153 SLAYIHSIGICHRDIKPQNLLLDPPSGVLKLIDFGSAKILIAGEPNVSYICSR-YYRAPE 211 Query: 180 VLSGQGYDGSAADIWSCGVILFVILAG 206 ++ G + DIWS G ++ ++ G Sbjct: 212 LIFGATNYTTNIDIWSTGCVMAELMQG 238 >4CSV-A nrPDB Length = 275 Score = 90.5 bits (223), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 59/200 (29%), Positives = 98/200 (49%), Gaps = 9/200 (4%) Query: 15 RTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRL 74 R +G G F +V + + VA+K + + T+ V++ +E IMK ++HPN+V+L Sbjct: 17 RKLGSGQFGEVYEGKWRNYNIEVAVKTLKEGTM----SVEEFLQEAQIMKKLKHPNLVQL 72 Query: 75 YEVLASPSKIYIVLEFVTGGELFD--RIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYH 132 Y V IYI+ E+++ G L D R + Q+ +A+ + H Sbjct: 73 YGVCTKEPPIYIITEYMSHGSLLDYLRDCEGHTVNAQALLDMAAQVASGMAYLESQNFIH 132 Query: 133 RDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTP-NYVAPEVLSGQGYDGSAA 191 RDL N L+ N +KV+DFGL+ L E R P + APE +S + + Sbjct: 133 RDLAARNCLVGENNVVKVADFGLARLINEDEYTARAGAKFPIKWTAPEAISYNRFS-IKS 191 Query: 192 DIWSCGVILFVILA-GYLPF 210 D+W+ G++L+ I G +P+ Sbjct: 192 DVWAFGILLWEIFTYGQVPY 211 >4KIK-B nrPDB Length = 677 Score = 89.7 bits (221), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 64/215 (29%), Positives = 101/215 (46%), Gaps = 16/215 (7%) Query: 8 VGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR 67 G +E+ +G G F V N +TG+ +AIK + +NR ++ EI IM+ + Sbjct: 18 CGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNR--ERWCLEIQIMRRLT 75 Query: 68 HPNIVRLYEV------LASPSKIYIVLEFVTGGEL---FDRIVHKGRLEESESRKYFQQL 118 HPN+V +V LA + +E+ GG+L ++ + L E + Sbjct: 76 HPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDI 135 Query: 119 VDAVAHCHCKGVYHRDLKPENLLLDTNGNL---KVSDFGLSALPQEGVELLRTTCGTPNY 175 A+ + H + HRDLKPEN++L K+ D G + +G L + GT Y Sbjct: 136 ASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQG-SLCTSFVGTLQY 194 Query: 176 VAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPF 210 +APE+L Q Y + D WS G + F + G+ PF Sbjct: 195 LAPELLEQQKYTVT-VDYWSFGTLAFECITGFRPF 228 >5G6V-A nrPDB Length = 324 Score = 89.7 bits (221), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 76/286 (26%), Positives = 129/286 (45%), Gaps = 48/286 (16%) Query: 17 IGEGTFAKVKFARNTDTGDNVAIKIM-------AKSTILKNRMVDQIKREISIMKIVRHP 69 +GEGT+A V ++ T + VA+K + A T + RE+S++K ++H Sbjct: 10 LGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAI---------REVSLLKDLKHA 60 Query: 70 NIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQ-QLVDAVAHCHCK 128 NIV L++++ + + +V E++ +L + G + + K F QL+ +A+CH + Sbjct: 61 NIVTLHDIIHTEKSLTLVFEYL-DKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQ 119 Query: 129 GVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDG 188 V HRDLKP+NLL++ G LK++DFGL+ + T Y P++L G Sbjct: 120 KVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYDNEVVTLWYRPPDILLGSTDYS 179 Query: 189 SAADIWSCGVILFVILAGYLPF-------------------SETDLPGL----------Y 219 + D+W G I + + G F +E PG+ Y Sbjct: 180 TQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNY 239 Query: 220 RKINA-AEFSCPPWFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWF 264 K A A S P ++ L+ ++L + RI + K P+F Sbjct: 240 PKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFF 285 >5AIR-A nrPDB Length = 430 Score = 89.4 bits (220), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 73/216 (33%), Positives = 109/216 (50%), Gaps = 38/216 (17%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 Y + IG G+F V A+ D+G+ VAIK + + KNR E+ IM+ + H N Sbjct: 66 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNR-------ELQIMRKLDHCN 118 Query: 71 IVRL----YEVLASPSKIYI--VLEFVTGGELFDRIV-HKGRLEESES----RKYFQQLV 119 IVRL Y ++Y+ VL++V E R+ H R +++ + Y QL Sbjct: 119 IVRLRYFFYSSGEKKDEVYLNLVLDYVP--ETVYRVARHYSRAKQTLPVIYVKLYMYQLF 176 Query: 120 DAVAHCHCKGVYHRDLKPENLLLDTN-GNLKVSDFGLSALPQEGVELLRTTCGTPN---- 174 ++A+ H G+ HRD+KP+NLLLD + LK+ DFG +L+R G PN Sbjct: 177 RSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFG------SAKQLVR---GEPNVSYI 227 Query: 175 ----YVAPEVLSGQGYDGSAADIWSCGVILFVILAG 206 Y APE++ G S+ D+WS G +L +L G Sbjct: 228 CSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLG 263 >4M7I-A nrPDB Length = 299 Score = 89.4 bits (220), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 83/291 (28%), Positives = 131/291 (45%), Gaps = 41/291 (14%) Query: 6 RRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMV--DQIKREISIM 63 R + +E + +G G F V A+N N AIK + L NR + +++ RE+ + Sbjct: 2 RYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIR----LPNRELAREKVMREVKAL 57 Query: 64 KIVRHPNIVRLYEVL-----------ASPS-KIYIVLEFVTGGELFDRIVHKGRLEESES 111 + HP IVR + +SP +YI ++ L D + + +EE E Sbjct: 58 AKLEHPGIVRYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERER 117 Query: 112 R---KYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGL-SALPQEGVELLR 167 F Q+ +AV H KG+ HRDLKP N+ + +KV DFGL +A+ Q+ E Sbjct: 118 SVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTV 177 Query: 168 TT-----------CGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLP 216 T GT Y++PE + G Y DI+S G+ILF +L PFS T + Sbjct: 178 LTPMPAYARHTGQVGTKLYMSPEQIHGNSY-SHKVDIFSLGLILFELL---YPFS-TQME 232 Query: 217 GLYRKINAAEFSCPPWFSAEVK---FLIHRILDPNPKTRIQIQGIKKDPWF 264 + + PP F+ + ++ +L P+P R + I ++ F Sbjct: 233 RVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVF 283 >5O0Y-A nrPDB Length = 579 Score = 89.0 bits (219), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 70/229 (30%), Positives = 106/229 (46%), Gaps = 22/229 (9%) Query: 58 REISIMKIVRHPNIVRLYEVLASPSKIYI-VLEFVTGGELFDRIVHKGRLEESESRKYFQ 116 RE I K + HP IV+LY+ + + + VLE+ G +L + + E E+R Sbjct: 337 REYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIM 396 Query: 117 QLVDAVAHCH--CKGVYHRDLKPENLLL---DTNGNLKVSDFGLSALPQE-------GVE 164 Q+V+A+ + + + H DLKP N+LL G +K++DFGLS + + G+E Sbjct: 397 QIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGME 456 Query: 165 LLRTTCGTPNYVAPEVL---SGQGYDGSAADIWSCGVILFVILAGYLPF----SETDLPG 217 L GT Y+ PE + D+WS GVI + L G PF S+ D+ Sbjct: 457 LTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQ 516 Query: 218 LYRKINAAEFSCPPW--FSAEVKFLIHRILDPNPKTRIQIQGIKKDPWF 264 + A E PP + E K I R L + RI +Q + DP+ Sbjct: 517 ENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 565 >4C59-A nrPDB Length = 340 Score = 89.0 bits (219), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 84/279 (30%), Positives = 124/279 (44%), Gaps = 44/279 (15%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMK-IVRH 68 + V R + EG FA V A++ +G A+K + + KNR + Q E+ MK + H Sbjct: 28 RLRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRAIIQ---EVCFMKKLSGH 84 Query: 69 PNIVRLYEVLA--------SPSKIYIVLEFVTGG--ELFDRIVHKGRLEESESRKYFQQL 118 PNIV+ + ++ ++ E G E ++ +G L K F Q Sbjct: 85 PNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGPLSCDTVLKIFYQT 144 Query: 119 VDAVAHCHCKG--VYHRDLKPENLLLDTNGNLKVSDFGLS----------------ALPQ 160 AV H H + + HRDLK ENLLL G +K+ DFG + AL + Sbjct: 145 CRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVE 204 Query: 161 EGVELLRTTCGTPNYVAPEV--LSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGL 218 E E+ R T TP Y PE+ L G DIW+ G IL+++ PF + G Sbjct: 205 E--EITRNT--TPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFED----GA 256 Query: 219 YRKINAAEFSCPPWFSAEVKF--LIHRILDPNPKTRIQI 255 +I ++S PP + F LI +L NP+ R+ I Sbjct: 257 KLRIVNGKYSIPPHDTQYTVFHSLIRAMLQVNPEERLSI 295 >5AWM-A nrPDB Length = 394 Score = 89.0 bits (219), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 72/245 (29%), Positives = 114/245 (46%), Gaps = 18/245 (7%) Query: 15 RTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKN-RMVDQIKREISIMKIVRHPNIVR 73 R IG G V A +T T NVAIK +++ +N + RE +MK+V H NI+ Sbjct: 50 RPIGSGAQGIVCAAYDTITQQNVAIKKLSRP--FQNVTHAKRAYREFKLMKLVNHKNIIG 107 Query: 74 LYEVLASPSK-------IYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCH 126 L +P + +Y+V+E + V + L+ Q++ + H H Sbjct: 108 LLNAF-TPQRNLEEFQDVYLVMELMDANLC---QVIQMDLDHDRMSYLLYQMLCGIKHLH 163 Query: 127 CKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTT-CGTPNYVAPEVLSGQG 185 G+ HRDLKP N+++ + LK+ DFGL+ G + T T Y APEV+ G G Sbjct: 164 SAGIIHRDLKPSNIVVKADCTLKILDFGLAR--TAGTTFMMTPYVVTRYYRAPEVILGMG 221 Query: 186 YDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRIL 245 Y + DIWS G I+ ++ G + F TD + KI + P F ++ + + Sbjct: 222 YTEN-VDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYV 280 Query: 246 DPNPK 250 + P+ Sbjct: 281 ENRPR 285 >4YHJ-A nrPDB Length = 584 Score = 88.6 bits (218), Expect = 5e-18, Method: Compositional matrix adjust. Identities = 79/288 (27%), Positives = 138/288 (47%), Gaps = 18/288 (6%) Query: 15 RTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRL 74 R +G+G F +V + TG A K + K I K + E I++ V+ +V L Sbjct: 191 RVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSRFVVSL 250 Query: 75 YEVLASPSKIYIVLEFVTGGELFDRIVHKGR--LEESESRKYFQQLVDAVAHCHCKGVYH 132 + + +VL + GG+L I + G +E + Y +L + + + + Sbjct: 251 AYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQRERIVY 310 Query: 133 RDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSAAD 192 RDLKPEN+LLD G++++SD GL+ EG + +R GT Y+APEV++ + Y S D Sbjct: 311 RDLKPENILLDDRGHIRISDLGLATEIPEG-QRVRGRVGTVGYMAPEVVNNEKYTFS-PD 368 Query: 193 IWSCGVILFVILAGYLPFSETDLPGLYRKI------NAAEFSCPPWFSAEVKFLIHRILD 246 W G +++ ++ G+ PF + + ++ + E+S FS + K + +L Sbjct: 369 WWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYS--EKFSEDAKSICRMLLT 426 Query: 247 PNPKTRIQIQ-----GIKKDPWFR-LNYVPIRAREEEEVNLDDIRAVF 288 NP R+ + G+K+ P F+ +N+ + A E D AV+ Sbjct: 427 KNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVY 474 >3MIA-A nrPDB Length = 351 Score = 88.2 bits (217), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 67/214 (31%), Positives = 107/214 (50%), Gaps = 31/214 (14%) Query: 8 VGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR 67 V KYE IG+GTF +V AR+ TG VA+K + + + + REI I+++++ Sbjct: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITAL-REIKILQLLK 74 Query: 68 HPNIVRLYEVL---ASP-----SKIYIVLEFV---TGGELFDRIVHKGRLEESESRKYFQ 116 H N+V L E+ ASP IY+V +F G L + +V + SE ++ Q Sbjct: 75 HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLV---KFTLSEIKRVMQ 131 Query: 117 QLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPN-- 174 L++ + + H + HRD+K N+L+ +G LK++DFGL+ L + + PN Sbjct: 132 MLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLA----RAFSLAKNS--QPNRY 185 Query: 175 --------YVAPEVLSGQGYDGSAADIWSCGVIL 200 Y PE+L G+ G D+W G I+ Sbjct: 186 TNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIM 219 >2XS0-A nrPDB Length = 386 Score = 88.2 bits (217), Expect = 7e-18, Method: Compositional matrix adjust. Identities = 72/249 (28%), Positives = 119/249 (47%), Gaps = 16/249 (6%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRM-VDQIKREISIMKIVRH 68 +Y+ + IG G V A + NVAIK +++ +N+ + RE+ +MK V H Sbjct: 27 RYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP--FQNQTHAKRAYRELVLMKCVNH 84 Query: 69 PNIVRLYEVLASPSK-------IYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDA 121 NI+ L V +P K +YIV+E + +++ E S +Q L Sbjct: 85 KNIIGLLNVF-TPQKSLEEFQDVYIVMELMDAN--LCQVIQMELDHERMSYLLYQMLC-G 140 Query: 122 VAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVL 181 + H H G+ HRDLKP N+++ ++ LK+ DFGL+ ++ T Y APEV+ Sbjct: 141 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMVPFVV-TRYYRAPEVI 199 Query: 182 SGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLI 241 G GY + DIWS G I+ ++ G + F TD + K+ + P F +++ + Sbjct: 200 LGMGYKEN-VDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQPTV 258 Query: 242 HRILDPNPK 250 ++ PK Sbjct: 259 RTYVENRPK 267 >6CTH-A nrPDB Length = 309 Score = 87.4 bits (215), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 63/197 (31%), Positives = 104/197 (52%), Gaps = 13/197 (6%) Query: 17 IGEGTFAKV--KFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRL 74 +GEG F V F R++DT +A+K +++++ + + + E+ I+ +RH N+V+L Sbjct: 23 LGEGGFGSVYRGFLRDSDT--YIAVKKVSRAS---KQGIKEYASEVKIISRLRHKNLVKL 77 Query: 75 YEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESR-KYFQQLVDAVAHCHCKG---V 130 ++ +V EF+ G L I L E R + + L A+ + H +G V Sbjct: 78 IGWCHERGELMLVYEFMANGSLDSHIFKGKSLLTWEVRYRIVKDLASALLYLHEEGDHCV 137 Query: 131 YHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRT-TCGTPNYVAPEVLSGQGYDGS 189 HRD+K N++LD++ N K+ DFGL+ L L +T GT Y+APE LS G Sbjct: 138 LHRDIKTSNIMLDSSFNAKLGDFGLARLVDHAKGLKKTLLAGTVGYMAPECLS-SGKASK 196 Query: 190 AADIWSCGVILFVILAG 206 +D++S GV+ I +G Sbjct: 197 ESDVYSFGVVALEIASG 213 >4UYA-A nrPDB Length = 340 Score = 87.0 bits (214), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 64/217 (29%), Positives = 103/217 (47%), Gaps = 18/217 (8%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTIL-KNRMVDQIKREISIMKIVRH 68 + E+ IG G F +V R T G VA+K + + ++RE + ++RH Sbjct: 27 RLELKELIGAGGFGQVY--RATWQGQEVAVKAARQDPEQDAAAAAESVRREARLFAMLRH 84 Query: 69 PNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCK 128 PNI+ L V + +VLEF GG L +R + R+ + Q+ + + H + Sbjct: 85 PNIIELRGVCLQQPHLCLVLEFARGGAL-NRALAGRRIPPHVLVNWAVQIARGMLYLHEE 143 Query: 129 G---VYHRDLKPENLLL--------DTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVA 177 + HRDLK N+LL N LK++DFGL+ ++ T G ++A Sbjct: 144 AFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKM--ATAGAYAWMA 201 Query: 178 PEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETD 214 PEV+ + +DIWS GV+L+ +L G +P+ D Sbjct: 202 PEVIKSSLFS-KGSDIWSYGVLLWELLTGEVPYRGID 237 >4HVI-A nrPDB Length = 314 Score = 87.0 bits (214), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 75/267 (28%), Positives = 124/267 (46%), Gaps = 28/267 (10%) Query: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQ---IKREISIMKIVRHPNIVR 73 +G+G F V+ R GDN + K L++ DQ +REI I+K + IV+ Sbjct: 18 LGKGNFGSVELCRYDPLGDNTGALVAVKQ--LQHSGPDQQRDFQREIQILKALHSDFIVK 75 Query: 74 LYEVLASPSK--IYIVLEFVTGGELFDRIV-HKGRLEESESRKYFQQLVDAVAHCHCKGV 130 V P + + +V+E++ G L D + H+ RL+ S Y Q+ + + + Sbjct: 76 YRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRC 135 Query: 131 YHRDLKPENLLLDTNGNLKVSDFGLSA-LP-QEGVELLRTTCGTP-NYVAPEVLSGQGYD 187 HRDL N+L+++ ++K++DFGL+ LP + ++R +P + APE LS + Sbjct: 136 VHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIF- 194 Query: 188 GSAADIWSCGVILFVIL----------AGYLPF--SETDLPGLYR----KINAAEFSCPP 231 +D+WS GV+L+ + A +L SE D+P L R PP Sbjct: 195 SRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGSERDVPALSRLLELLEEGQRLPAPP 254 Query: 232 WFSAEVKFLIHRILDPNPKTRIQIQGI 258 AEV L+ P+P+ R + Sbjct: 255 ACPAEVHELMKLCWAPSPQDRPSFSAL 281 >5Z33-A nrPDB Length = 425 Score = 87.0 bits (214), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 67/208 (32%), Positives = 106/208 (50%), Gaps = 15/208 (7%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR-H 68 +Y V + +G+G + V A N T + VAIK + + K + + REI +++ R H Sbjct: 32 RYTVTKELGQGAYGIVCAAVNNQTSEGVAIKKVT-NVFSKKILAKRALREIKLLQHFRGH 90 Query: 69 PNIVRLYEV-LASP---SKIYIVLEFVTGGELFDRIVHKGR-LEESESRKYFQQLVDAVA 123 NI LY++ + P ++ Y+ E + I+ G+ L ++ + + Q++ + Sbjct: 91 RNITCLYDMDIPRPDNFNETYLYEELMECD--LAAIIRSGQPLTDAHFQSFIYQILCGLK 148 Query: 124 HCHCKGVYHRDLKPENLLLDTNGNLKVSDFGL----SALPQEGVELLRTTCGTPNYVAPE 179 + H V HRDLKP NLL++ + LK+ DFGL S P+E + T Y APE Sbjct: 149 YIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSVDPEENAGYMTEYVATRWYRAPE 208 Query: 180 V-LSGQGYDGSAADIWSCGVILFVILAG 206 + LS Q Y A D+WS G IL +L G Sbjct: 209 IMLSFQSYT-KAIDVWSVGCILAELLGG 235 >4GS6-A nrPDB Length = 315 Score = 86.3 bits (212), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 77/270 (28%), Positives = 120/270 (44%), Gaps = 25/270 (9%) Query: 12 EVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNI 71 EV +G G F V A+ +VAIK + + K +V E+ + V HPNI Sbjct: 12 EVEEVVGRGAFGVVCKAKWR--AKDVAIKQIESESERKAFIV-----ELRQLSRVNHPNI 64 Query: 72 VRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGR----LEESESRKYFQQLVDAVAHCHC 127 V+LY +P + +V+E+ GG L++ ++H + + + Q VA+ H Sbjct: 65 VKLYGACLNP--VCLVMEYAEGGSLYN-VLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHS 121 Query: 128 ---KGVYHRDLKPENLLLDTNGN-LKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSG 183 K + HRDLKP NLLL G LK+ DFG + Q + G+ ++APEV G Sbjct: 122 MQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTH---MTNNKGSAAWMAPEVFEG 178 Query: 184 QGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPW---FSAEVKFL 240 Y D++S G+IL+ ++ PF E P + PP ++ L Sbjct: 179 SNYS-EKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESL 237 Query: 241 IHRILDPNPKTRIQIQGIKKDPWFRLNYVP 270 + R +P R ++ I K + Y P Sbjct: 238 MTRCWSKDPSQRPSMEEIVKIMTHLMRYFP 267 >4UY9-A nrPDB Length = 323 Score = 86.3 bits (212), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 71/260 (27%), Positives = 122/260 (46%), Gaps = 28/260 (10%) Query: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILK-NRMVDQIKREISIMKIVRHPNIVRLY 75 IG G F KV R GD VA+K ++ ++ +++E + +++HPNI+ L Sbjct: 17 IGIGGFGKVY--RAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALR 74 Query: 76 EVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVY---H 132 V + +V+EF GG L +R++ R+ + Q+ + + H + + H Sbjct: 75 GVCLKEPNLCLVMEFARGGPL-NRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIH 133 Query: 133 RDLKPENLLL--------DTNGNLKVSDFGLSALPQEGVELLRTT----CGTPNYVAPEV 180 RDLK N+L+ +N LK++DFGL+ E RTT GT ++APEV Sbjct: 134 RDLKSSNILILQKVENGDLSNKILKITDFGLAR------EWHRTTKMSAAGTYAWMAPEV 187 Query: 181 LSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKF- 239 + + +D+WS GV+L+ +L G +PF D + + + + P + F Sbjct: 188 IRASMF-SKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFA 246 Query: 240 -LIHRILDPNPKTRIQIQGI 258 L+ +P+P +R I Sbjct: 247 KLMEDCWNPDPHSRPSFTNI 266 >5VD3-A nrPDB Length = 311 Score = 86.3 bits (212), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 77/257 (29%), Positives = 122/257 (47%), Gaps = 20/257 (7%) Query: 17 IGEGTFAKVKFARNTDTGDNVAIK-IMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLY 75 +G G++ +V R+ + G A+K M+ K+R ++ S K+ +HP VRL Sbjct: 65 LGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDR-ARKLAEVGSHEKVGQHPCCVRLE 123 Query: 76 EVLASPSKIYIVLEFVTGGELFDRIVHKG-RLEESESRKYFQQLVDAVAHCHCKGVYHRD 134 + +Y+ E + G L G L E++ Y + + A+AH H +G+ H D Sbjct: 124 QAWEEGGILYLQTE-LCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLD 182 Query: 135 LKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTC-----GTPNYVAPEVLSGQGYDGS 189 +KP N+ L G K+ DFGL VEL G P Y+APE+L QG G+ Sbjct: 183 VKPANIFLGPRGRCKLGDFGLL------VELGTAGAGEVQEGDPRYMAPELL--QGSYGT 234 Query: 190 AADIWSCGV-ILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILDPN 248 AAD++S G+ IL V LP L + EF+ S+E++ ++ +L+P+ Sbjct: 235 AADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTA--GLSSELRSVLVMMLEPD 292 Query: 249 PKTRIQIQGIKKDPWFR 265 PK R + + P R Sbjct: 293 PKLRATAEALLALPVLR 309 >5HI2-A nrPDB Length = 283 Score = 85.5 bits (210), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 58/217 (26%), Positives = 110/217 (50%), Gaps = 27/217 (12%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 G+ VG+ IG G+F V + GD VA+K+ L + + K E+ +++ RH Sbjct: 20 GQITVGQRIGSGSFGTV--YKGKWHGD-VAVKM------LTPQQLQAFKNEVGVLRKTRH 70 Query: 69 PNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVD-------A 121 NI+ L+ ++ ++ IV ++ G L+ L SE++ ++L+D Sbjct: 71 VNIL-LFMGYSTKPQLAIVTQWCEGSSLYHH------LHASETKFEMKKLIDIARQTARG 123 Query: 122 VAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQ--EGVELLRTTCGTPNYVAPE 179 + + H K + HRDLK N+ L + +K+ DFGL+ + G G+ ++APE Sbjct: 124 MDYLHAKSIIHRDLKSNNIFLHEDNTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPE 183 Query: 180 VLSGQGYDGSA--ADIWSCGVILFVILAGYLPFSETD 214 V+ Q + + +D+++ G++L+ ++ G LP+S + Sbjct: 184 VIRMQDSNPYSFQSDVYAFGIVLYELMTGQLPYSNIN 220 >3FI2-A nrPDB Length = 353 Score = 85.5 bits (210), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 71/250 (28%), Positives = 118/250 (47%), Gaps = 18/250 (7%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRM-VDQIKREISIMKIVRH 68 +Y+ + IG G V A + NVAIK +++ +N+ + RE+ +MK V H Sbjct: 25 RYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP--FQNQTHAKRAYRELVLMKCVNH 82 Query: 69 PNIVRLYEVLASPSK-------IYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDA 121 NI+ L V +P K +Y+V+E + +++ E S +Q L Sbjct: 83 KNIISLLNVF-TPQKTLEEFQDVYLVMELMDAN--LCQVIQMELDHERMSYLLYQMLC-G 138 Query: 122 VAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTT-CGTPNYVAPEV 180 + H H G+ HRDLKP N+++ ++ LK+ DFGL+ G + T T Y APEV Sbjct: 139 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLAR--TAGTSFMMTPYVVTRYYRAPEV 196 Query: 181 LSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFL 240 + G GY + DIWS G I+ ++ + F D + K+ + P F +++ Sbjct: 197 ILGMGYKEN-VDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPT 255 Query: 241 IHRILDPNPK 250 + ++ PK Sbjct: 256 VRNYVENRPK 265 >3HMP-A nrPDB Length = 342 Score = 85.5 bits (210), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 75/278 (26%), Positives = 133/278 (47%), Gaps = 21/278 (7%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIM-KIVRHP 69 Y + + IG G +KV F + AIK + N+ +D + EI+ + K+ +H Sbjct: 58 YSILKQIGSGGSSKV-FQVLNEKKQIYAIKYVNLEE-ADNQTLDSYRNEIAYLNKLQQHS 115 Query: 70 N-IVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCK 128 + I+RLY+ + IY+V+E +L + K ++ E + Y++ +++AV H Sbjct: 116 DKIIRLYDYEITDQYIYMVME-CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQH 174 Query: 129 GVYHRDLKPENLLLDTNGNLKVSDFGLS--ALPQEGVELLRTTCGTPNYVAPEV---LSG 183 G+ H DLKP N L+ +G LK+ DFG++ P + + GT NY+ PE +S Sbjct: 175 GIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSS 233 Query: 184 QGYDG-------SAADIWSCGVILFVILAGYLPFSE--TDLPGLYRKINA-AEFSCPPWF 233 +G +D+WS G IL+ + G PF + + L+ I+ E P Sbjct: 234 SRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIP 293 Query: 234 SAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVPI 271 +++ ++ L +PK RI I + P+ ++ P+ Sbjct: 294 EKDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQTHPV 331 >6NPU-A nrPDB Length = 298 Score = 85.1 bits (209), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 65/221 (29%), Positives = 104/221 (47%), Gaps = 16/221 (7%) Query: 10 KYEVGRT-------IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISI 62 K+E+ RT +G G + +V VA+K + + T+ V++ +E ++ Sbjct: 20 KWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTM----EVEEFLKEAAV 75 Query: 63 MKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQ--QLVD 120 MK ++HPN+V+L V YI+ EF+T G L D + R E + + Q+ Sbjct: 76 MKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISS 135 Query: 121 AVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTP-NYVAPE 179 A+ + K HRDL N L+ N +KV+DFGLS L P + APE Sbjct: 136 AMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPE 195 Query: 180 VLSGQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLY 219 L+ + +D+W+ GV+L+ I G P+ DL +Y Sbjct: 196 SLAYNKF-SIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVY 235 >5AP3-A nrPDB Length = 313 Score = 84.7 bits (208), Expect = 8e-17, Method: Compositional matrix adjust. Identities = 75/278 (26%), Positives = 133/278 (47%), Gaps = 21/278 (7%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIM-KIVRHP 69 Y + + IG G +KV F + AIK + N+ +D + EI+ + K+ +H Sbjct: 30 YSILKQIGSGGSSKV-FQVLNEKKQIYAIKYVNLEE-ADNQTLDSYRNEIAYLNKLQQHS 87 Query: 70 N-IVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCK 128 + I+RLY+ + IY+V+E +L + K ++ E + Y++ +++AV H Sbjct: 88 DKIIRLYDYEITDQYIYMVME-CGNIDLNGWLKKKKSIDPWERKSYWKNMLEAVHTIHQH 146 Query: 129 GVYHRDLKPENLLLDTNGNLKVSDFGLS--ALPQEGVELLRTTCGTPNYVAPEV---LSG 183 G+ H DLKP N L+ +G LK+ DFG++ P + + GT NY+ PE +S Sbjct: 147 GIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSS 205 Query: 184 QGYDG-------SAADIWSCGVILFVILAGYLPFSE--TDLPGLYRKINA-AEFSCPPWF 233 +G +D+WS G IL+ + G PF + + L+ I+ E P Sbjct: 206 SRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIP 265 Query: 234 SAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVPI 271 +++ ++ L +PK RI I + P+ ++ P+ Sbjct: 266 EKDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQTHPV 303 >4EWQ-A nrPDB Length = 383 Score = 84.7 bits (208), Expect = 8e-17, Method: Compositional matrix adjust. Identities = 60/215 (27%), Positives = 105/215 (48%), Gaps = 20/215 (9%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAK---STILKNRMVDQIKREISIMKIV 66 +Y+ +G G + V A +T TG VA+K +++ S I R RE+ ++K + Sbjct: 46 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTY----RELRLLKHM 101 Query: 67 RHPNIVRLYEVLASPSK-------IYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLV 119 +H N++ L +V +P++ +Y+V + G + IV +L + + Q++ Sbjct: 102 KHENVIGLLDVF-TPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQIL 158 Query: 120 DAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPE 179 + + H + HRDLKP NL ++ + LK+ DFGL+ + + + T Y APE Sbjct: 159 RGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLA---RHTDDEMTGYVATRWYRAPE 215 Query: 180 VLSGQGYDGSAADIWSCGVILFVILAGYLPFSETD 214 ++ + DIWS G I+ +L G F TD Sbjct: 216 IMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTD 250 >5IKW-A nrPDB Length = 310 Score = 84.7 bits (208), Expect = 8e-17, Method: Compositional matrix adjust. Identities = 85/274 (31%), Positives = 135/274 (49%), Gaps = 37/274 (13%) Query: 8 VGKYEVG--RTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQ--IKREISIM 63 VG+++V ++ EG F+ V R T G A+K M N M D KREI+IM Sbjct: 11 VGRHQVTLEESLAEGGFSTVFLVR-THGGIRCALKRM-----YVNNMPDLNVCKREITIM 64 Query: 64 K-IVRHPNIVRLYEVLASPS-----KIYIVLEFVTGGELFDRIVHKGR--LEESESRKYF 115 K + H NIV + + ++ I++E+ G++ +++ K + E E + F Sbjct: 65 KELSGHKNIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIF 124 Query: 116 QQLVDAVAHCH-CKG-VYHRDLKPENLLLDTNGNLKVSDFGLSA----LPQ-EGVELLRT 168 +AVA H CK + HRDLK EN+LL+ GN + DFG + PQ +GV ++ Sbjct: 125 CDTCEAVARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEE 184 Query: 169 TC---GTPNYVAPEVLSGQGYD--GSAADIWSCGVILFVILAGYLPFSETDLPGLYRKIN 223 T +Y APE+++ G + ADIW+ G +L+ + LPF E+ + I Sbjct: 185 EIKKYTTLSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPFGESQV-----AIC 239 Query: 224 AAEFSCP--PWFSAEVKFLIHRILDPNPKTRIQI 255 F+ P +S + LI +L+P+P+ R I Sbjct: 240 DGNFTIPDNSRYSRNIHCLIRFMLEPDPEHRPDI 273 >1JNK-A nrPDB Length = 423 Score = 84.7 bits (208), Expect = 8e-17, Method: Compositional matrix adjust. Identities = 71/250 (28%), Positives = 118/250 (47%), Gaps = 18/250 (7%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRM-VDQIKREISIMKIVRH 68 +Y+ + IG G V A + NVAIK +++ +N+ + RE+ +MK V H Sbjct: 63 RYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP--FQNQTHAKRAYRELVLMKCVNH 120 Query: 69 PNIVRLYEVLASPSK-------IYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDA 121 NI+ L V +P K +Y+V+E + +++ E S +Q L Sbjct: 121 KNIISLLNVF-TPQKTLEEFQDVYLVMELMDAN--LCQVIQMELDHERMSYLLYQMLC-G 176 Query: 122 VAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTT-CGTPNYVAPEV 180 + H H G+ HRDLKP N+++ ++ LK+ DFGL+ G + T T Y APEV Sbjct: 177 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLAR--TAGTSFMMTPYVVTRYYRAPEV 234 Query: 181 LSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFL 240 + G GY + DIWS G I+ ++ + F D + K+ + P F +++ Sbjct: 235 ILGMGYKEN-VDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPT 293 Query: 241 IHRILDPNPK 250 + ++ PK Sbjct: 294 VRNYVENRPK 303 >2PMN-X nrPDB Length = 348 Score = 84.3 bits (207), Expect = 8e-17, Method: Compositional matrix adjust. Identities = 60/255 (23%), Positives = 121/255 (47%), Gaps = 29/255 (11%) Query: 1 MTKKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNR--------- 51 + +K + + Y + RT+ +G F K+ + A+K KS + K R Sbjct: 23 VKEKDKYINDYRIIRTLNQGKFNKIILCEKDNKF--YALKKYEKSLLEKKRDFTKSNNDK 80 Query: 52 -----MVDQIKREISIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRL 106 D K E+ I+ +++ + ++ + ++YI+ E++ + + L Sbjct: 81 ISIKSKYDDFKNELQIITDIKNEYCLTCEGIITNYDEVYIIYEYMENDSILKFDEYFFVL 140 Query: 107 EESES--------RKYFQQLVDAVAHCHC-KGVYHRDLKPENLLLDTNGNLKVSDFGLSA 157 +++ + + + ++++ ++ H K + HRD+KP N+L+D NG +K+SDFG S Sbjct: 141 DKNYTCFIPIQVIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMDKNGRVKLSDFGESE 200 Query: 158 LPQEGVELLRTTCGTPNYVAPEVLSGQ-GYDGSAADIWSCGVILFVILAGYLPFS-ETDL 215 + + ++ + GT ++ PE S + Y+G+ DIWS G+ L+V+ +PFS + L Sbjct: 201 YMVD--KKIKGSRGTYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMFYNVVPFSLKISL 258 Query: 216 PGLYRKINAAEFSCP 230 L+ I P Sbjct: 259 VELFNNIRTKNIEYP 273 >2W1I-A nrPDB Length = 326 Score = 84.3 bits (207), Expect = 9e-17, Method: Compositional matrix adjust. Identities = 59/201 (29%), Positives = 103/201 (51%), Gaps = 14/201 (6%) Query: 15 RTIGEGTFAKVKFAR----NTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 + +G+G F V+ R +TG+ VA+K + ST + +REI I+K ++H N Sbjct: 47 QQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHST---EEHLRDFEREIEILKSLQHDN 103 Query: 71 IVRLYEVLASPSK--IYIVLEFVTGGELFDRIV-HKGRLEESESRKYFQQLVDAVAHCHC 127 IV+ V S + + +++E++ G L D + HK R++ + +Y Q+ + + Sbjct: 104 IVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGT 163 Query: 128 KGVYHRDLKPENLLLDTNGNLKVSDFGLS-ALPQEGVELLRTTCGTPN--YVAPEVLSGQ 184 K HRDL N+L++ +K+ DFGL+ LPQ+ G + APE L+ Sbjct: 164 KRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTES 223 Query: 185 GYDGSAADIWSCGVILFVILA 205 + A+D+WS GV+L+ + Sbjct: 224 KF-SVASDVWSFGVVLYELFT 243 >4XEY-B nrPDB Length = 408 Score = 84.3 bits (207), Expect = 9e-17, Method: Compositional matrix adjust. Identities = 65/221 (29%), Positives = 104/221 (47%), Gaps = 16/221 (7%) Query: 10 KYEVGRT-------IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISI 62 K+E+ RT +G G + +V VA+K + + T+ V++ +E ++ Sbjct: 119 KWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTM----EVEEFLKEAAV 174 Query: 63 MKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQ--QLVD 120 MK ++HPN+V+L V YI+ EF+T G L D + R E + + Q+ Sbjct: 175 MKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISS 234 Query: 121 AVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTP-NYVAPE 179 A+ + K HRDL N L+ N +KV+DFGLS L P + APE Sbjct: 235 AMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPE 294 Query: 180 VLSGQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLY 219 L+ + +D+W+ GV+L+ I G P+ DL +Y Sbjct: 295 SLAYNKFS-IKSDVWAFGVLLWEIATYGMSPYPGIDLSQVY 334 >4EBW-A nrPDB Length = 304 Score = 84.0 bits (206), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 72/259 (27%), Positives = 124/259 (47%), Gaps = 15/259 (5%) Query: 10 KYEVGRTIGEGTFAKVK---FARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIV 66 + E+GR IGEG F V + + VAIK T + + ++ +E M+ Sbjct: 39 RIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCT--SDSVREKFLQEALTMRQF 96 Query: 67 RHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRI-VHKGRLEESESRKYFQQLVDAVAHC 125 HP+IV+L V+ + ++I++E T GEL + V K L+ + Y QL A+A+ Sbjct: 97 DHPHIVKLIGVITE-NPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYL 155 Query: 126 HCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTP-NYVAPEVLSGQ 184 K HRD+ N+L+ +N +K+ DFGLS ++ + P ++APE ++ + Sbjct: 156 ESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFR 215 Query: 185 GYDGSAADIWSCGVILF-VILAGYLPFS---ETDLPGLYRKINAAEFSCPPWFSAEVKFL 240 + SA+D+W GV ++ +++ G PF D+ G R N PP + L Sbjct: 216 RFT-SASDVWMFGVCMWEILMHGVKPFQGVKNNDVIG--RIENGERLPMPPNCPPTLYSL 272 Query: 241 IHRILDPNPKTRIQIQGIK 259 + + +P R + +K Sbjct: 273 MTKCWAYDPSRRPRFTELK 291 >5NGU-A nrPDB Length = 381 Score = 84.0 bits (206), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 62/199 (31%), Positives = 98/199 (49%), Gaps = 14/199 (7%) Query: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYE 76 IGEG + V A D + V + I S + REI I+ RH NI+ + + Sbjct: 50 IGEGAYGMVCSA--YDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGIND 107 Query: 77 VLASPS-----KIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVY 131 ++ +P+ +YIV + + +L+ +++ L + Q++ + + H V Sbjct: 108 IIRAPTIEQMKDVYIVQDLMET-DLY-KLLKTQHLSNDHICYFLYQILRGLKYIHSANVL 165 Query: 132 HRDLKPENLLLDTNGNLKVSDFGLSALP---QEGVELLRTTCGTPNYVAPEV-LSGQGYD 187 HRDLKP NLLL+T +LK+ DFGL+ + + L T Y APE+ L+ +GY Sbjct: 166 HRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYT 225 Query: 188 GSAADIWSCGVILFVILAG 206 S DIWS G IL +L+ Sbjct: 226 KS-IDIWSVGCILAEMLSN 243 >3IO7-A nrPDB Length = 313 Score = 84.0 bits (206), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 59/201 (29%), Positives = 103/201 (51%), Gaps = 14/201 (6%) Query: 15 RTIGEGTFAKVKFAR----NTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 + +G+G F V+ R +TG+ VA+K + ST + +REI I+K ++H N Sbjct: 34 QQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHST---EEHLRDFEREIEILKSLQHDN 90 Query: 71 IVRLYEVLASPSK--IYIVLEFVTGGELFDRIV-HKGRLEESESRKYFQQLVDAVAHCHC 127 IV+ V S + + +++E++ G L D + HK R++ + +Y Q+ + + Sbjct: 91 IVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGT 150 Query: 128 KGVYHRDLKPENLLLDTNGNLKVSDFGLS-ALPQEGVELLRTTCGTPN--YVAPEVLSGQ 184 K HRDL N+L++ +K+ DFGL+ LPQ+ G + APE L+ Sbjct: 151 KRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTES 210 Query: 185 GYDGSAADIWSCGVILFVILA 205 + A+D+WS GV+L+ + Sbjct: 211 KF-SVASDVWSFGVVLYELFT 230 >3GC9-A nrPDB Length = 370 Score = 83.6 bits (205), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 55/208 (26%), Positives = 101/208 (48%), Gaps = 16/208 (7%) Query: 15 RTIGEGTFAKVKFARNTDTGDNVAIKIMAK--STILKNRMVDQIKREISIMKIVRHPNIV 72 R +G G + V A + VA+K +++ +++ R + RE+ ++K ++H N++ Sbjct: 34 RPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHAR---RTYRELRLLKHLKHENVI 90 Query: 73 RLYEVLASP------SKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCH 126 L +V S++Y+V + G + IV L + + QL+ + + H Sbjct: 91 GLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKSQALSDEHVQFLVYQLLRGLKYIH 148 Query: 127 CKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGY 186 G+ HRDLKP N+ ++ + L++ DFGL+ ++ E + T Y APE++ + Sbjct: 149 SAGIIHRDLKPSNVAVNEDSELRILDFGLA---RQADEEMTGYVATRWYRAPEIMLNWMH 205 Query: 187 DGSAADIWSCGVILFVILAGYLPFSETD 214 DIWS G I+ +L G F +D Sbjct: 206 YNQTVDIWSVGCIMAELLQGKALFPGSD 233 >3DTC-A nrPDB Length = 271 Score = 83.6 bits (205), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 70/260 (26%), Positives = 121/260 (46%), Gaps = 28/260 (10%) Query: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILK-NRMVDQIKREISIMKIVRHPNIVRLY 75 IG G F KV R GD VA+K ++ ++ +++E + +++HPNI+ L Sbjct: 15 IGIGGFGKVY--RAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALR 72 Query: 76 EVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVY---H 132 V + +V+EF GG L +R++ R+ + Q+ + + H + + H Sbjct: 73 GVCLKEPNLCLVMEFARGGPL-NRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIH 131 Query: 133 RDLKPENLLL--------DTNGNLKVSDFGLSALPQEGVELLRTT----CGTPNYVAPEV 180 RDLK N+L+ +N LK++DFGL+ E RTT G ++APEV Sbjct: 132 RDLKSSNILILQKVENGDLSNKILKITDFGLAR------EWHRTTKMSAAGAYAWMAPEV 185 Query: 181 LSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKF- 239 + + +D+WS GV+L+ +L G +PF D + + + + P + F Sbjct: 186 IRASMFS-KGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFA 244 Query: 240 -LIHRILDPNPKTRIQIQGI 258 L+ +P+P +R I Sbjct: 245 KLMEDCWNPDPHSRPSFTNI 264 >6GVJ-A nrPDB Length = 429 Score = 83.6 bits (205), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 75/278 (26%), Positives = 133/278 (47%), Gaps = 21/278 (7%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIM-KIVRHP 69 Y + + IG G +KV F + AIK + N+ +D + EI+ + K+ +H Sbjct: 146 YSILKQIGSGGSSKV-FQVLNEKKQIYAIKYVNLEE-ADNQTLDSYRNEIAYLNKLQQHS 203 Query: 70 N-IVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCK 128 + I+RLY+ + IY+V+E +L + K ++ E + Y++ +++AV H Sbjct: 204 DKIIRLYDYEITDQYIYMVME-CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQH 262 Query: 129 GVYHRDLKPENLLLDTNGNLKVSDFGLS--ALPQEGVELLRTTCGTPNYVAPEV---LSG 183 G+ H DLKP N L+ +G LK+ DFG++ P + + GT NY+ PE +S Sbjct: 263 GIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSS 321 Query: 184 QGYDG-------SAADIWSCGVILFVILAGYLPFSE--TDLPGLYRKINA-AEFSCPPWF 233 +G +D+WS G IL+ + G PF + + L+ I+ E P Sbjct: 322 SRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIP 381 Query: 234 SAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVPI 271 +++ ++ L +PK RI I + P+ ++ P+ Sbjct: 382 EKDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQTHPV 419 >4PWN-A nrPDB Length = 274 Score = 83.6 bits (205), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 69/261 (26%), Positives = 125/261 (47%), Gaps = 18/261 (6%) Query: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYE 76 IG G+F V +T+T VA + + K+ + K E ++K ++HPNIVR Y+ Sbjct: 18 IGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSER-QRFKEEAEMLKGLQHPNIVRFYD 76 Query: 77 VLASPSK----IYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKG--V 130 S K I +V E +T G L + ++ R + +Q++ + H + + Sbjct: 77 SWESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGLQFLHTRTPPI 136 Query: 131 YHRDLKPENLLLD-TNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGS 189 HRDLK +N+ + G++K+ D GL+ L + ++ GTP ++APE+ + YD S Sbjct: 137 IHRDLKCDNIFITGPTGSVKIGDLGLATLEKRA-SFAKSVIGTPEFMAPEMYE-EKYDES 194 Query: 190 AADIWSCGVILFVILAGYLPFSET-DLPGLYRKINAAEFSCPPWFSA----EVKFLIHRI 244 D+++ G+ + + P+SE + +YR++ + P F EVK +I Sbjct: 195 -VDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSG--VKPASFDKVAIPEVKEIIEGC 251 Query: 245 LDPNPKTRIQIQGIKKDPWFR 265 + N R I+ + +F+ Sbjct: 252 IRQNKDERYSIKDLLNHAFFQ 272 >4JLC-A nrPDB Length = 657 Score = 83.6 bits (205), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 63/216 (29%), Positives = 100/216 (46%), Gaps = 19/216 (8%) Query: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYE 76 +G+G A V R+ TGD A+K+ + L R VD RE ++K + H NIV+L+ Sbjct: 16 LGQGATANVFRGRHKKTGDLYAVKVFNNISFL--RPVDVQMREFEVLKKLNHKNIVKLFA 73 Query: 77 VLASPSKIY--IVLEFVTGGELFDRIVHKGR---LEESESRKYFQQLVDAVAHCHCKGVY 131 + + + +++EF G L+ + L ESE + +V + H G+ Sbjct: 74 IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIV 133 Query: 132 HRDLKPENLLL----DTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVL------ 181 HRD+KP N++ D K++DFG +A E E + GT Y+ P++ Sbjct: 134 HRDIKPGNIMRVIGEDGQSVYKLTDFG-AARELEDDEQFVSLYGTEEYLHPDMYERAVLR 192 Query: 182 -SGQGYDGSAADIWSCGVILFVILAGYLPFSETDLP 216 Q G+ D+WS GV + G LPF + P Sbjct: 193 KDHQKKYGATVDLWSVGVTFYHAATGSLPFRPFEGP 228 >5HVK-A nrPDB Length = 315 Score = 83.2 bits (204), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 67/275 (24%), Positives = 124/275 (45%), Gaps = 36/275 (13%) Query: 14 GRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVR 73 G +G+G F + + +TG+ + +K + + R +E+ +M+ + HPN+++ Sbjct: 19 GEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQR---TFLKEVKVMRCLEHPNVLK 75 Query: 74 LYEVLASPSKIYIVLEFVTGGELFDRI-VHKGRLEESESRKYFQQLVDAVAHCHCKGVYH 132 VL ++ + E++ GG L I + S+ + + + +A+ H + H Sbjct: 76 FIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIH 135 Query: 133 RDLKPENLLLDTNGNLKVSDFGLSAL------PQEGVELLR--------TTCGTPNYVAP 178 R+L N L+ N N+ V+DFGL+ L EG+ L+ T G P ++AP Sbjct: 136 RNLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAP 195 Query: 179 EVLSGQGYDGSAADIWSCGVILFVILA------GYLPFSETDLPGLYRKINAAEF---SC 229 E+++G+ YD D++S G++L I+ YLP + + +N F C Sbjct: 196 EMINGRSYD-EKVDVFSFGIVLCEIIGRVNADPDYLPRT------MDFGLNVRGFLDRYC 248 Query: 230 PPWFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWF 264 PP + R D +P+ R +K + W Sbjct: 249 PPNCPPSFFPITVRCCDLDPEKRPSF--VKLEHWL 281 >2ZMD-A nrPDB Length = 390 Score = 83.2 bits (204), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 74/278 (26%), Positives = 132/278 (47%), Gaps = 21/278 (7%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIM-KIVRHP 69 Y + + IG G +KV F + AIK + N+ +D + EI+ + K+ +H Sbjct: 58 YSILKQIGSGGSSKV-FQVLNEKKQIYAIKYVNLEEA-DNQTLDSYRNEIAYLNKLQQHS 115 Query: 70 N-IVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCK 128 + I+RLY+ + IY+V+E +L + K ++ E + Y++ +++AV H Sbjct: 116 DKIIRLYDYEITDQYIYMVME-CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQH 174 Query: 129 GVYHRDLKPENLLLDTNGNLKVSDFGLS--ALPQEGVELLRTTCGTPNYVAPEV---LSG 183 G+ H DLKP N L+ +G LK+ DFG++ P + + G NY+ PE +S Sbjct: 175 GIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGAVNYMPPEAIKDMSS 233 Query: 184 QGYDG-------SAADIWSCGVILFVILAGYLPFSE--TDLPGLYRKINA-AEFSCPPWF 233 +G +D+WS G IL+ + G PF + + L+ I+ E P Sbjct: 234 SRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIP 293 Query: 234 SAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVPI 271 +++ ++ L +PK RI I + P+ ++ P+ Sbjct: 294 EKDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQTHPV 331 >1G3N-A nrPDB Length = 326 Score = 83.2 bits (204), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 65/202 (32%), Positives = 101/202 (50%), Gaps = 15/202 (7%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDN-VAIKIMAKSTILKNRMVDQIKREISIMK---I 65 +YE IGEG + KV AR+ G VA+K + T + + I RE+++++ Sbjct: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTI-REVAVLRHLET 70 Query: 66 VRHPNIVRLYEVLA-----SPSKIYIVLEFVTGG--ELFDRIVHKGRLEESESRKYFQQL 118 HPN+VRL++V +K+ +V E V D++ G E+ FQ L Sbjct: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQ-L 129 Query: 119 VDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAP 178 + + H V HRDLKP+N+L+ ++G +K++DFGL+ + + L T Y AP Sbjct: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVV-TLWYRAP 188 Query: 179 EVLSGQGYDGSAADIWSCGVIL 200 EVL Y + D+WS G I Sbjct: 189 EVLLQSSY-ATPVDLWSVGCIF 209 >5O2B-A nrPDB Length = 285 Score = 83.2 bits (204), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 73/282 (25%), Positives = 131/282 (46%), Gaps = 25/282 (8%) Query: 1 MTKKMRRVGKYEVGR------TIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVD 54 M +M+ V GR +G G F V +T+T VA + + K Sbjct: 2 MEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQ-Q 60 Query: 55 QIKREISIMKIVRHPNIVRLYE----VLASPSKIYIVLEFVTGGELFDRIVHKGRLEESE 110 + K E ++K ++HPNIVR Y+ +L I +V E +T G L + ++ Sbjct: 61 RFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKV 120 Query: 111 SRKYFQQLVDAVAHCHCKG--VYHRDLKPENLLLD-TNGNLKVSDFGLSALPQEGVELLR 167 R + +Q++ + H + + HRDLK +N+ + G++K+ D GL+ L + + Sbjct: 121 LRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMR--TSFAK 178 Query: 168 TTCGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSET-DLPGLYRKINAAE 226 + GTP ++APE+ + YD S D+++ G+ + + P+SE + +YRK+ + Sbjct: 179 SVIGTPEFMAPEMYE-EHYDES-VDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSG- 235 Query: 227 FSCPPWFS----AEVKFLIHRILDPNPKTRIQIQGIKKDPWF 264 P F+ EVK +I + N R+ I+ + +F Sbjct: 236 -IKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFF 276 >4F0G-A nrPDB Length = 287 Score = 83.2 bits (204), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 65/214 (30%), Positives = 110/214 (51%), Gaps = 18/214 (8%) Query: 12 EVGRTIGEGTFAKVKFARNTDTGDNVAIK-IMAKSTILKNRMVD---QIKREISIMKIVR 67 E + IG+G F V R VAIK ++ + + M++ + +RE+ IM + Sbjct: 22 EYEKQIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQREVFIMSNLN 81 Query: 68 HPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGR-LEESESRKYFQQLVDAVAHCH 126 HPNIV+LY ++ +P + +V+EFV G+L+ R++ K ++ S + + + + Sbjct: 82 HPNIVKLYGLMHNPPR--MVMEFVPCGDLYHRLLDKAHPIKWSVKLRLMLDIALGIEYMQ 139 Query: 127 CKG--VYHRDLKPENLL---LDTNGNL--KVSDFGLSALPQEGVELLRTTCGTPNYVAPE 179 + + HRDL+ N+ LD N + KV+DFGLS Q+ V + G ++APE Sbjct: 140 NQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLS---QQSVHSVSGLLGNFQWMAPE 196 Query: 180 VLSGQGYDGS-AADIWSCGVILFVILAGYLPFSE 212 + + + AD +S +IL+ IL G PF E Sbjct: 197 TIGAEEESYTEKADTYSFAMILYTILTGEGPFDE 230 >4QTB-A nrPDB Length = 380 Score = 82.8 bits (203), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 85/320 (26%), Positives = 135/320 (42%), Gaps = 50/320 (15%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 +Y + IGEG + V A + VAIK + S + REI I+ RH Sbjct: 42 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKI--SPFEHQTYCQRTLREIQILLRFRHE 99 Query: 70 NIVRLYEVLASPS-----KIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAH 124 N++ + ++L + + +YIV + + +L+ +++ +L + Q++ + + Sbjct: 100 NVIGIRDILRASTLEAMRDVYIVQDLMET-DLY-KLLKSQQLSNDHICYFLYQILRGLKY 157 Query: 125 CHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALP---QEGVELLRTTCGTPNYVAPEV- 180 H V HRDLKP NLL++T +LK+ DFGL+ + + L T Y APE+ Sbjct: 158 IHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIM 217 Query: 181 LSGQGYDGSAADIWSCGVILFVILAGYLPF-------------------SETD------- 214 L+ +GY S DIWS G IL +L+ F S+ D Sbjct: 218 LNSKGYTKS-IDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINM 276 Query: 215 -----LPGLYRKINAAEFSCPPWFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYV 269 L L K A P ++ L+ R+L NP RI ++ P+ Y Sbjct: 277 KARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYD 336 Query: 270 PIRAREEEE-----VNLDDI 284 P EE + LDD+ Sbjct: 337 PTDEPVAEEPFTFAMELDDL 356 >4E93-A nrPDB Length = 377 Score = 82.8 bits (203), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 65/197 (32%), Positives = 92/197 (46%), Gaps = 16/197 (8%) Query: 13 VGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIV 72 +G IG G F +V R DN + + + L + + +E I+K HPNIV Sbjct: 118 LGEQIGRGNFGEVFSGRLR--ADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHPNIV 175 Query: 73 RLYEVLASPSKIYIVLEFVTGGELFDRIVHKG-RLEESESRKYFQQLVDAVA---HCHCK 128 RL V IYIV+E V GG+ + +G RL + Q + DA A + K Sbjct: 176 RLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARL---RVKTLLQMVGDAAAGMEYLESK 232 Query: 129 GVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVEL----LRTTCGTPNYVAPEVLSGQ 184 HRDL N L+ LK+SDFG+S +GV LR + APE L+ Sbjct: 233 CCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQV--PVKWTAPEALNYG 290 Query: 185 GYDGSAADIWSCGVILF 201 Y S +D+WS G++L+ Sbjct: 291 RYS-SESDVWSFGILLW 306 >4TPT-A nrPDB Length = 303 Score = 82.8 bits (203), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 64/249 (25%), Positives = 112/249 (44%), Gaps = 35/249 (14%) Query: 14 GRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVR 73 G +G+G F + + TG + +K + + E+ +M+ + HPN+++ Sbjct: 5 GEVLGKGFFGQAIKVTHKATGKVMVMKELIRC---DEETQKTFLTEVKVMRSLDHPNVLK 61 Query: 74 LYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHR 133 VL K+ ++ E++ GG L D + + ++ + + +A+ H + HR Sbjct: 62 FIGVLYKDKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLHSMCIIHR 121 Query: 134 DLKPENLLLDTNGNLKVSDFGLSAL--------PQEGVELLR------------TTCGTP 173 DL N L+ + + V+DFGLS L P E + T G P Sbjct: 122 DLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGNP 181 Query: 174 NYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETD-LP-----GLYRKINAAEF 227 ++APE+L+G+ YD DI+S G++L I+ +++ D LP GL K+ +F Sbjct: 182 YWMAPEMLNGKSYD-ETVDIFSFGIVLCEIIGQV--YADPDCLPRTLDFGLNVKLFWEKF 238 Query: 228 ---SCPPWF 233 CPP F Sbjct: 239 VPTDCPPAF 247 >4YFF-A nrPDB Length = 311 Score = 82.4 bits (202), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 62/211 (29%), Positives = 104/211 (49%), Gaps = 7/211 (3%) Query: 7 RVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIV 66 ++ + E IG G+F KV R + VAIK +T VD RE+SI+ + Sbjct: 40 QLSEIEFHEIIGSGSFGKVYKGRCRNK--IVAIKRYRANTYCSKSDVDMFCREVSILCQL 97 Query: 67 RHPNIVRLY-EVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQ-QLVDAVAH 124 HP +++ L PS+ IV ++++GG LF + + R+ + +S+ + + + Sbjct: 98 NHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEY 157 Query: 125 CH--CKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVE-LLRTTCGTPNYVAPEVL 181 H + + HRDL N+LL +G+ V+DFG S Q E + G ++APEV Sbjct: 158 LHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVF 217 Query: 182 SGQGYDGSAADIWSCGVILFVILAGYLPFSE 212 + AD++S + L+ IL G +PF+ Sbjct: 218 TQCTRYTIKADVFSYALCLWEILTGEIPFAH 248 >4AN9-A nrPDB Length = 301 Score = 82.4 bits (202), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 64/225 (28%), Positives = 107/225 (47%), Gaps = 15/225 (6%) Query: 41 IMAKSTI---LKNRMVDQIKREISIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELF 97 +MA+ I +K + +QI RE+ ++ P IV Y S +I I +E + GG L Sbjct: 36 VMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLD 95 Query: 98 DRIVHKGRLEESESRKYFQQLVDAVAHCHCKG-VYHRDLKPENLLLDTNGNLKVSDFGLS 156 + GR+ E K ++ + + K + HRD+KP N+L+++ G +K+ DFG+S Sbjct: 96 QVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVS 155 Query: 157 ALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLP 216 Q E+ GT +Y++PE L G Y +DIWS G+ L + G P Sbjct: 156 G--QLIDEMANEFVGTRSYMSPERLQGTHYS-VQSDIWSMGLSLVEMAVGRYPRPPM--- 209 Query: 217 GLYRKINAAEFSCPP-----WFSAEVKFLIHRILDPNPKTRIQIQ 256 ++ ++ PP FS E + +++ L NP R ++ Sbjct: 210 AIFELLDYIVNEPPPKLPSAVFSLEFQDFVNKCLIKNPAERADLK 254 >4EUT-A nrPDB Length = 396 Score = 82.4 bits (202), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 63/216 (29%), Positives = 100/216 (46%), Gaps = 19/216 (8%) Query: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYE 76 +G+G A V R+ TGD AIK+ + L R VD RE ++K + H NIV+L+ Sbjct: 17 LGQGATANVFRGRHKKTGDLFAIKVFNNISFL--RPVDVQMREFEVLKKLNHKNIVKLFA 74 Query: 77 VLASPSKIY--IVLEFVTGGELFDRIVHKGR---LEESESRKYFQQLVDAVAHCHCKGVY 131 + + + +++EF G L+ + L ESE + +V + H G+ Sbjct: 75 IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIV 134 Query: 132 HRDLKPENLLL----DTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVL------ 181 HR++KP N++ D K++DFG +A E E + GT Y+ P++ Sbjct: 135 HRNIKPGNIMRVIGEDGQSVYKLTDFG-AARELEDDEQFVSLYGTEEYLHPDMYERAVLR 193 Query: 182 -SGQGYDGSAADIWSCGVILFVILAGYLPFSETDLP 216 Q G+ D+WS GV + G LPF + P Sbjct: 194 KDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGP 229 >2XYN-A nrPDB Length = 292 Score = 82.4 bits (202), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 68/243 (27%), Positives = 111/243 (45%), Gaps = 23/243 (9%) Query: 6 RRVGKYEVGRT-------IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKR 58 + + K+E+ RT +G G + +V VA+K + + T+ V++ + Sbjct: 22 QSMDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTM----EVEEFLK 77 Query: 59 EISIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQ-- 116 E ++MK ++HPN+V+L V YIV E++ G L D + R E + + Sbjct: 78 EAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMAT 137 Query: 117 QLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTP-NY 175 Q+ A+ + K HRDL N L+ N +KV+DFGLS L P + Sbjct: 138 QISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKW 197 Query: 176 VAPEVLSGQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLY------RKINAAEFS 228 APE L+ + +D+W+ GV+L+ I G P+ DL +Y ++ E Sbjct: 198 TAPESLAYNTFS-IKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPE-G 255 Query: 229 CPP 231 CPP Sbjct: 256 CPP 258 >6NT9-A nrPDB Length = 742 Score = 82.4 bits (202), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 63/216 (29%), Positives = 100/216 (46%), Gaps = 19/216 (8%) Query: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYE 76 +G+G A V R+ TGD AIK+ + L R VD RE ++K + H NIV+L+ Sbjct: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFL--RPVDVQMREFEVLKKLNHKNIVKLFA 72 Query: 77 VLASPSKIY--IVLEFVTGGELFDRIVHKGR---LEESESRKYFQQLVDAVAHCHCKGVY 131 + + + +++EF G L+ + L ESE + +V + H G+ Sbjct: 73 IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIV 132 Query: 132 HRDLKPENLLL----DTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVL------ 181 HR++KP N++ D K++DFG +A E E + GT Y+ P++ Sbjct: 133 HRNIKPGNIMRVIGEDGQSVYKLTDFG-AARELEDDEQFVSLYGTEEYLHPDMYERAVLR 191 Query: 182 -SGQGYDGSAADIWSCGVILFVILAGYLPFSETDLP 216 Q G+ D+WS GV + G LPF + P Sbjct: 192 KDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGP 227 >6DBM-A nrPDB Length = 318 Score = 82.0 bits (201), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 61/199 (30%), Positives = 103/199 (51%), Gaps = 13/199 (6%) Query: 15 RTIGEGTFAKVKF----ARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 R +GEG F KV N TG+ VA+K + ++R K+EI I++ + H + Sbjct: 37 RDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAGPQHR--SGWKQEIDILRTLYHEH 94 Query: 71 IVRLYEVL--ASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCK 128 I++ A + + +V+E+V G L D + + + ++ + QQ+ + +A+ H + Sbjct: 95 IIKYKGCCEDAGAASLQLVMEYVPLGSLRDYLP-RHSIGLAQLLLFAQQICEGMAYLHSQ 153 Query: 129 GVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVEL--LRTTCGTP-NYVAPEVLSGQG 185 HRDL N+LLD + +K+ DFGL+ EG E +R +P + APE L Sbjct: 154 HYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYK 213 Query: 186 YDGSAADIWSCGVILFVIL 204 + A+D+WS GV L+ +L Sbjct: 214 FY-YASDVWSFGVTLYELL 231 >5O2C-A nrPDB Length = 380 Score = 82.0 bits (201), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 68/260 (26%), Positives = 124/260 (47%), Gaps = 19/260 (7%) Query: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYE 76 +G G F V +T+T VA + + K + K E ++K ++HPNIVR Y+ Sbjct: 33 LGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQ-QRFKEEAEMLKGLQHPNIVRFYD 91 Query: 77 ----VLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKG--V 130 +L I +V E +T G L + ++ R + +Q++ + H + + Sbjct: 92 SWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPPI 151 Query: 131 YHRDLKPENLLLD-TNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGS 189 HRDLK +N+ + G++K+ D GL+ L + ++ GTP ++APE+ + YD S Sbjct: 152 IHRDLKCDNIFITGPTGSVKIGDLGLATLMR--TSFAKSVIGTPEFMAPEMYE-EHYDES 208 Query: 190 AADIWSCGVILFVILAGYLPFSET-DLPGLYRKINAAEFSCPPWFS----AEVKFLIHRI 244 D+++ G+ + + P+SE + +YRK+ + P F+ EVK +I Sbjct: 209 -VDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSG--IKPASFNKVTDPEVKEIIEGC 265 Query: 245 LDPNPKTRIQIQGIKKDPWF 264 + N R+ I+ + +F Sbjct: 266 IRQNKSERLSIRDLLNHAFF 285 >2FO0-A nrPDB Length = 495 Score = 82.0 bits (201), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 64/221 (28%), Positives = 104/221 (47%), Gaps = 16/221 (7%) Query: 10 KYEVGRT-------IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISI 62 K+E+ RT +G G + +V VA+K + + T+ V++ +E ++ Sbjct: 211 KWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTM----EVEEFLKEAAV 266 Query: 63 MKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQ--QLVD 120 MK ++HPN+V+L V YI+ EF+T G L D + R E + + Q+ Sbjct: 267 MKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISS 326 Query: 121 AVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTP-NYVAPE 179 A+ + K HR+L N L+ N +KV+DFGLS L P + APE Sbjct: 327 AMEYLEKKNFIHRNLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPE 386 Query: 180 VLSGQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLY 219 L+ + +D+W+ GV+L+ I G P+ DL +Y Sbjct: 387 SLAYNKFS-IKSDVWAFGVLLWEIATYGMSPYPGIDLSQVY 426 >3OZ6-A nrPDB Length = 388 Score = 82.0 bits (201), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 74/245 (30%), Positives = 115/245 (46%), Gaps = 32/245 (13%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIK-REISIM-KIVR 67 KYE+ + +G+G + V + + TG+ VA+K + + +N Q REI I+ ++ Sbjct: 10 KYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIFDA--FQNSTDAQRTFREIMILTELSG 67 Query: 68 HPNIVRLYEVLASPSK--IYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHC 125 H NIV L VL + + +Y+V +++ ++ LE + QL+ + + Sbjct: 68 HENIVNLLNVLRADNDRDVYLVFDYMETD--LHAVIRANILEPVHKQYVVYQLIKVIKYL 125 Query: 126 HCKGVYHRDLKPENLLLDTNGNLKVSDFGLS-----------ALP---QEGVE------- 164 H G+ HRD+KP N+LL+ ++KV+DFGLS +P E E Sbjct: 126 HSGGLLHRDMKPSNILLNAECHVKVADFGLSRSFVNIRRVTNNIPLSINENTENFDDDQP 185 Query: 165 LLRTTCGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAG--YLPFSETDLPGLYRKI 222 +L T Y APE+L G D+WS G IL IL G P S T + L R I Sbjct: 186 ILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGKPIFPGSST-MNQLERII 244 Query: 223 NAAEF 227 +F Sbjct: 245 GVIDF 249 >4EUU-A nrPDB Length = 319 Score = 81.6 bits (200), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 63/216 (29%), Positives = 100/216 (46%), Gaps = 19/216 (8%) Query: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYE 76 +G+G A V R+ TGD AIK+ + L R VD RE ++K + H NIV+L+ Sbjct: 17 LGQGATANVFRGRHKKTGDLFAIKVFNNISFL--RPVDVQMREFEVLKKLNHKNIVKLFA 74 Query: 77 VLASPSKIY--IVLEFVTGGELFDRIVHKGR---LEESESRKYFQQLVDAVAHCHCKGVY 131 + + + +++EF G L+ + L ESE + +V + H G+ Sbjct: 75 IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIV 134 Query: 132 HRDLKPENLLL----DTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVL------ 181 HR++KP N++ D K++DFG +A E E + GT Y+ P++ Sbjct: 135 HRNIKPGNIMRVIGEDGQSVYKLTDFG-AARELEDDEQFVSLYGTEEYLHPDMYERAVLR 193 Query: 182 -SGQGYDGSAADIWSCGVILFVILAGYLPFSETDLP 216 Q G+ D+WS GV + G LPF + P Sbjct: 194 KDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGP 229 >3GC0-A nrPDB Length = 329 Score = 81.6 bits (200), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 56/197 (28%), Positives = 97/197 (49%), Gaps = 7/197 (3%) Query: 8 VGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR 67 + +Y +GEGT+ +V A +T T + VAIK + + + + RE+S++K ++ Sbjct: 33 IDRYRRITKLGEGTYGEVYKAIDTVTNETVAIKRI-RLEHEEEGVPGTAIREVSLLKELQ 91 Query: 68 HPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHC 127 H NI+ L V+ +++++ E+ +L + + + + QL++ V CH Sbjct: 92 HRNIIELKSVIHHNHRLHLIFEYAEN-DLKKYMDKNPDVSMRVIKSFLYQLINGVNFCHS 150 Query: 128 KGVYHRDLKPENLLLDTNGN-----LKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLS 182 + HRDLKP+NLLL + LK+ DFGL+ + T Y PE+L Sbjct: 151 RRCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQFTHEIITLWYRPPEILL 210 Query: 183 GQGYDGSAADIWSCGVI 199 G + ++ DIWS I Sbjct: 211 GSRHYSTSVDIWSIACI 227 >5HIE-A nrPDB Length = 302 Score = 81.6 bits (200), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 55/211 (26%), Positives = 108/211 (51%), Gaps = 15/211 (7%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 G+ VG+ IG G+F V + GD VA+K+ L + + K E+ +++ RH Sbjct: 36 GQITVGQRIGSGSFGTV--YKGKWHGD-VAVKM------LTPQQLQAFKNEVGVLRKTRH 86 Query: 69 PNIVRLYEVLASPSKIYIVLEFVTGGELFDRI-VHKGRLEESESRKYFQQLVDAVAHCHC 127 NI+ L+ ++ ++ IV ++ G L+ + + + + E + +Q + + H Sbjct: 87 VNIL-LFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHA 145 Query: 128 KGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQ--EGVELLRTTCGTPNYVAPEVLSGQG 185 K + HRDLK N+ L + +K+ DFGL+ + G G+ ++APEV+ Q Sbjct: 146 KSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQD 205 Query: 186 YDGSA--ADIWSCGVILFVILAGYLPFSETD 214 + + +D+++ G++L+ ++ G LP+S + Sbjct: 206 KNPYSFQSDVYAFGIVLYELMTGQLPYSNIN 236 >5KKR-C nrPDB Length = 395 Score = 81.3 bits (199), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 55/178 (30%), Positives = 89/178 (50%), Gaps = 7/178 (3%) Query: 41 IMAKSTI---LKNRMVDQIKREISIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELF 97 +MA+ I +K + +QI RE+ ++ P IV Y S +I I +E + GG L Sbjct: 95 VMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLD 154 Query: 98 DRIVHKGRLEESESRKYFQQLVDAVAHCHCK-GVYHRDLKPENLLLDTNGNLKVSDFGLS 156 + GR+ E K ++ + + K + HRD+KP N+L+++ G +K+ DFG+S Sbjct: 155 QVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVS 214 Query: 157 ALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETD 214 Q + + GT +Y++PE L G Y +DIWS G+ L + G P D Sbjct: 215 G--QLIDSMANSFVGTRSYMSPERLQGTHYS-VQSDIWSMGLSLVEMAVGRYPIPPPD 269 >3EQC-A nrPDB Length = 360 Score = 81.3 bits (199), Expect = 8e-16, Method: Compositional matrix adjust. Identities = 55/178 (30%), Positives = 89/178 (50%), Gaps = 7/178 (3%) Query: 41 IMAKSTI---LKNRMVDQIKREISIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELF 97 +MA+ I +K + +QI RE+ ++ P IV Y S +I I +E + GG L Sbjct: 60 VMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLD 119 Query: 98 DRIVHKGRLEESESRKYFQQLVDAVAHCHCK-GVYHRDLKPENLLLDTNGNLKVSDFGLS 156 + GR+ E K ++ + + K + HRD+KP N+L+++ G +K+ DFG+S Sbjct: 120 QVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVS 179 Query: 157 ALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETD 214 Q + + GT +Y++PE L G Y +DIWS G+ L + G P D Sbjct: 180 G--QLIDSMANSFVGTRSYMSPERLQGTHYS-VQSDIWSMGLSLVEMAVGRYPIPPPD 234 >2J0K-A nrPDB Length = 656 Score = 81.3 bits (199), Expect = 8e-16, Method: Compositional matrix adjust. Identities = 66/233 (28%), Positives = 114/233 (48%), Gaps = 15/233 (6%) Query: 10 KYEVGRTIGEGTFAKVK---FARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIV 66 + E+GR IGEG F V + + VAIK T + + ++ +E M+ Sbjct: 391 RIELGRCIGEGQFGDVHQGIYMSPENPAMAVAIKTCKNCT--SDSVREKFLQEALTMRQF 448 Query: 67 RHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRI-VHKGRLEESESRKYFQQLVDAVAHC 125 HP+IV+L V+ + + ++I++E T GEL + V K L+ + Y QL A+A+ Sbjct: 449 DHPHIVKLIGVI-TENPVWIIMELCTLGELRSFLQVRKFSLDLASLILYAYQLSTALAYL 507 Query: 126 HCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTP-NYVAPEVLSGQ 184 K HRD+ N+L+ +K+ DFGLS ++ + P ++APE ++ + Sbjct: 508 ESKRFVHRDIAARNVLVSATDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFR 567 Query: 185 GYDGSAADIWSCGVILF-VILAGYLPFSETDLPGLYRKINAAEF-----SCPP 231 + SA+D+W GV ++ +++ G PF + +I E +CPP Sbjct: 568 RFT-SASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPP 619 >4HZS-A nrPDB Length = 341 Score = 81.3 bits (199), Expect = 9e-16, Method: Compositional matrix adjust. Identities = 59/192 (30%), Positives = 97/192 (50%), Gaps = 9/192 (4%) Query: 17 IGEGTFAKVKFAR-NTDTGD--NVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVR 73 +G+G+F V+ + +G +VA+K + + + +D RE++ M + H N++R Sbjct: 20 LGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNLIR 79 Query: 74 LYEVLASPSKIYIVLEFVTGGELFDRI-VHKGRLEESESRKYFQQLVDAVAHCHCKGVYH 132 LY V+ +P + +V E G L DR+ H+G +Y Q+ + + + K H Sbjct: 80 LYGVVLTPP-MKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYLESKRFIH 138 Query: 133 RDLKPENLLLDTNGNLKVSDFGL-SALPQEGVE-LLRTTCGTP-NYVAPEVLSGQGYDGS 189 RDL NLLL T +K+ DFGL ALPQ +++ P + APE L + + Sbjct: 139 RDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLKTRTF-SH 197 Query: 190 AADIWSCGVILF 201 A+D W GV L+ Sbjct: 198 ASDTWMFGVTLW 209 >1U54-B nrPDB Length = 291 Score = 81.3 bits (199), Expect = 9e-16, Method: Compositional matrix adjust. Identities = 59/192 (30%), Positives = 98/192 (51%), Gaps = 9/192 (4%) Query: 17 IGEGTFAKVKFAR-NTDTGD--NVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVR 73 +G+G+F V+ + +G +VA+K + + + +D RE++ M + H N++R Sbjct: 26 LGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNLIR 85 Query: 74 LYEVLASPSKIYIVLEFVTGGELFDRI-VHKGRLEESESRKYFQQLVDAVAHCHCKGVYH 132 LY V+ +P + +V E G L DR+ H+G +Y Q+ + + + K H Sbjct: 86 LYGVVLTPP-MKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYLESKRFIH 144 Query: 133 RDLKPENLLLDTNGNLKVSDFGL-SALPQ-EGVELLRTTCGTP-NYVAPEVLSGQGYDGS 189 RDL NLLL T +K+ DFGL ALPQ + +++ P + APE L + + Sbjct: 145 RDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLKTRTF-SH 203 Query: 190 AADIWSCGVILF 201 A+D W GV L+ Sbjct: 204 ASDTWMFGVTLW 215 >6O8B-A nrPDB Length = 665 Score = 80.9 bits (198), Expect = 9e-16, Method: Compositional matrix adjust. Identities = 63/216 (29%), Positives = 99/216 (45%), Gaps = 19/216 (8%) Query: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYE 76 +G+G A V R+ TGD AIK+ + L R VD RE ++K + H NIV+L+ Sbjct: 23 LGQGATANVFRGRHKKTGDLFAIKVFNNISFL--RPVDVQMREFEVLKKLNHKNIVKLFA 80 Query: 77 VLASPSKIY--IVLEFVTGGELFDRIVHKGR---LEESESRKYFQQLVDAVAHCHCKGVY 131 + + + +++EF G L+ + L ESE + +V + H G+ Sbjct: 81 IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIV 140 Query: 132 HRDLKPENLLL----DTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVL------ 181 HR++KP N++ D K++DFG +A E E GT Y+ P++ Sbjct: 141 HRNIKPGNIMRVIGEDGQSVYKLTDFG-AARELEDDEQFVELYGTEEYLHPDMYERAVLR 199 Query: 182 -SGQGYDGSAADIWSCGVILFVILAGYLPFSETDLP 216 Q G+ D+WS GV + G LPF + P Sbjct: 200 KDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGP 235 >3DKO-A nrPDB Length = 318 Score = 80.9 bits (198), Expect = 9e-16, Method: Compositional matrix adjust. Identities = 68/233 (29%), Positives = 109/233 (46%), Gaps = 18/233 (7%) Query: 12 EVGRTIGEGTFAKVKFARNTDTGDN---VAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 ++ R IG G F +V R G VAIK + K R E SIM H Sbjct: 46 KIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRR--DFLCEASIMGQFDH 103 Query: 69 PNIVRLYEVLASPSKIYIVLEFVTGGELFDRIV--HKGRLEESESRKYFQQLVDAVAHCH 126 PN+V L V+ + IV+EF+ G L D + H G+ + + + + + Sbjct: 104 PNVVHLEGVVTRGKPVMIVIEFMENGAL-DAFLRKHDGQFTVIQLVGMLRGIAAGMRYLA 162 Query: 127 CKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTP---NYVAPEVLSG 183 G HRDL N+L+++N KVSDFGLS + ++ E + TT G + APE + Sbjct: 163 DMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQY 222 Query: 184 QGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKIN-----AAEFSCP 230 + + SA+D+WS G++++ +++ G P+ + + + I A CP Sbjct: 223 RKFT-SASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPAPMDCP 274 >1S9I-A nrPDB Length = 354 Score = 80.9 bits (198), Expect = 9e-16, Method: Compositional matrix adjust. Identities = 57/178 (32%), Positives = 89/178 (50%), Gaps = 7/178 (3%) Query: 41 IMAKSTI---LKNRMVDQIKREISIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELF 97 IMA+ I +K + +QI RE+ ++ P IV Y S +I I +E + GG L Sbjct: 43 IMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLD 102 Query: 98 DRIVHKGRLEESESRKYFQQLVDAVAHCHCKG-VYHRDLKPENLLLDTNGNLKVSDFGLS 156 + R+ E K ++ +A+ K + HRD+KP N+L+++ G +K+ DFG+S Sbjct: 103 QVLKEAKRIPEEILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVS 162 Query: 157 ALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETD 214 Q + + GT +Y+APE L G Y +DIWS G+ L + G P D Sbjct: 163 G--QLIDSMANSFVGTRSYMAPERLQGTHYS-VQSDIWSMGLSLVELAVGRYPIPPPD 217 >3OHT-A nrPDB Length = 389 Score = 80.9 bits (198), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 55/214 (25%), Positives = 101/214 (47%), Gaps = 18/214 (8%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAK---STILKNRMVDQIKREISIMKIV 66 +Y+ +G G + V + + +G +A+K +++ S I R RE+ ++K + Sbjct: 52 RYQTLSPVGSGAYGSVCSSYDVKSGLKIAVKKLSRPFQSIIHAKRTY----RELRLLKHM 107 Query: 67 RHPNIVRLYEVLASPSK------IYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVD 120 +H N++ L +V + +Y+V + G + IV +L + + Q++ Sbjct: 108 KHENVIGLLDVFTPATSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQILR 165 Query: 121 AVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEV 180 + + H + HRDLKP NL ++ + LK+ DFGL+ + + + T Y APE+ Sbjct: 166 GLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLA---RHTDDEMTGYVATRWYRAPEI 222 Query: 181 LSGQGYDGSAADIWSCGVILFVILAGYLPFSETD 214 + + DIWS G I+ +L G F TD Sbjct: 223 MLNWMHYNMTVDIWSVGCIMAELLTGRTLFPGTD 256 >3KUL-B nrPDB Length = 325 Score = 80.9 bits (198), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 64/208 (30%), Positives = 100/208 (48%), Gaps = 9/208 (4%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGD-NVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 + + + IG G +V + R G +V + I A R E SIM H Sbjct: 50 RIHIEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGYTERQRRDFLSEASIMGQFDH 109 Query: 69 PNIVRLYEVLASPSKIYIVLEFVTGGEL--FDRIVHKGRLEESESRKYFQQLVDAVAHCH 126 PNI+RL V+ IV E++ G L F R H G+ + + + + + Sbjct: 110 PNIIRLEGVVTRGRLAMIVTEYMENGSLDTFLR-THDGQFTIMQLVGMLRGVGAGMRYLS 168 Query: 127 CKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTP---NYVAPEVLSG 183 G HRDL N+L+D+N KVSDFGLS + ++ + TT G + APE ++ Sbjct: 169 DLGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTAPEAIAF 228 Query: 184 QGYDGSAADIWSCGVILFVILA-GYLPF 210 + + SA+D+WS GV+++ +LA G P+ Sbjct: 229 RTFS-SASDVWSFGVVMWEVLAYGERPY 255 >5VO2-A nrPDB Length = 300 Score = 80.5 bits (197), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 64/252 (25%), Positives = 117/252 (46%), Gaps = 28/252 (11%) Query: 15 RTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRL 74 + +G G V R G+ VA+K ++ D + +I ++ ++HPNI+ Sbjct: 18 QWVGSGAQGAVFLGRFH--GEEVAVK----------KVRDLKETDIKHLRKLKHPNIITF 65 Query: 75 YEVLASPSKIYIVLEFVTGGELFDRIVHKGR-LEESESRKYFQQLVDAVAHCHCKGVYHR 133 V I++EF G+L++ ++ GR + S + + + + H + HR Sbjct: 66 KGVCTQAPCYCILMEFCAQGQLYE-VLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHR 124 Query: 134 DLKPENLLLDTNGNLKVSDFGLSA-LPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSAAD 192 DLK N+L+ + +K+SDFG S L + ++ + GT ++APEV+ + D Sbjct: 125 DLKSPNMLITYDDVVKISDFGTSKELSDKSTKM--SFAGTVAWMAPEVIRNEPV-SEKVD 181 Query: 193 IWSCGVILFVILAGYLPFSETDLPGLYRKINAAEF------SCPPWFSAEVKFLIHRILD 246 IWS GV+L+ +L G +P+ + D + + + SCP F K L+ + + Sbjct: 182 IWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGF----KILLRQCWN 237 Query: 247 PNPKTRIQIQGI 258 P+ R + I Sbjct: 238 SKPRNRPSFRQI 249 >1CM8-A nrPDB Length = 367 Score = 80.5 bits (197), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 59/207 (28%), Positives = 99/207 (47%), Gaps = 18/207 (8%) Query: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAK---STILKNRMVDQIKREISIMKIVRHPNIVR 73 +G G + V A + TG VAIK + + S + R RE+ ++K +RH N++ Sbjct: 33 VGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAY----RELRLLKHMRHENVIG 88 Query: 74 LYEV------LASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHC 127 L +V L + Y+V+ F+ G +++ +L E + Q++ + + H Sbjct: 89 LLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHA 146 Query: 128 KGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYD 187 G+ HRDLKP NL ++ + LK+ DFGL+ ++ + T Y APEV+ Sbjct: 147 AGIIHRDLKPGNLAVNEDCELKILDFGLA---RQADSEMTGYVVTRWYRAPEVILNWMRY 203 Query: 188 GSAADIWSCGVILFVILAGYLPFSETD 214 DIWS G I+ ++ G F +D Sbjct: 204 TQTVDIWSVGCIMAEMITGKTLFKGSD 230 >4QNY-A nrPDB Length = 354 Score = 80.5 bits (197), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 82/328 (25%), Positives = 137/328 (41%), Gaps = 50/328 (15%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDN-VAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 +Y + R IG G++ V AR+T + + VA+K + K + + +I REI ++ Sbjct: 21 RYLLERIIGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEEVILAKRILREIKLLAHFND 80 Query: 69 PNIVRLYEVLASPS-----KIYIVLEFVTGGELFDRIVHKGR-LEESESRKYFQQLVDAV 122 NI+ L +L YIV++ + +++ G+ L E+ + + Q + A+ Sbjct: 81 DNIIGLRNILTPEDPENFDHFYIVMDIMETD--LKQVLRSGQELTEAHIQFFIYQALRAL 138 Query: 123 AHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLS 182 H GV HRD+ P N+L++TN +LK+ DFGL+ + E + Y APE++ Sbjct: 139 HIIHSAGVIHRDITPANILVNTNCDLKICDFGLAKEENDQGEYMTDYVTMRWYRAPELVM 198 Query: 183 GQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRK------------INAAEFSCP 230 + D+W G IL +L F D K IN+ S Sbjct: 199 EDKDYSAQIDVWGIGCILGELLGSRPLFQGKDRVNQLDKIVDVIGTPSEEDINSVGSSAA 258 Query: 231 -------------------PWFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFR------ 265 P S E L+ +L NPK RI + + P+ Sbjct: 259 QKYLKKKSHRPQADWRQRYPTASPEALDLLRHMLVFNPKRRITVLQAMRHPFLEQLHDDA 318 Query: 266 ---LNYVPIRAREEEEVNLDDI-RAVFD 289 L+Y R E E+ + D+ RA+++ Sbjct: 319 DDNLSYALFRFDENEQKTIVDVKRAIYE 346 >4Y83-A nrPDB Length = 332 Score = 80.1 bits (196), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 57/195 (29%), Positives = 93/195 (47%), Gaps = 12/195 (6%) Query: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIK-REISIMKIVRHPNIVRLY 75 I G F KV A++ T +A K++ VDQ K ++ I RH NI LY Sbjct: 81 IPRGAFGKVYLAQDIKTKKRMACKLIP---------VDQFKPSDVEIQACFRHENIAELY 131 Query: 76 EVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDL 135 + +++ +E GG + +++ G + E E + ++ + H K V H D+ Sbjct: 132 GAVLWGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHHDI 191 Query: 136 KPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSAADIWS 195 KP N++ + + V DFGLS E V + GT Y++PEV+ +G+ + ADI+S Sbjct: 192 KPSNIVFMSTKAVLV-DFGLSVQMTEDVYFPKDLRGTEIYMSPEVILCRGH-STKADIYS 249 Query: 196 CGVILFVILAGYLPF 210 G L + G P+ Sbjct: 250 LGATLIHMQTGTPPW 264 >5X5O-A nrPDB Length = 310 Score = 80.1 bits (196), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 71/255 (27%), Positives = 112/255 (43%), Gaps = 35/255 (13%) Query: 18 GEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYEV 77 G G+F V A+ VA+K + K I++E I+ ++ H NI++ Y V Sbjct: 24 GGGSFGSVYRAKWISQDKEVAVKKLLK-----------IEKEAEILSVLSHRNIIQFYGV 72 Query: 78 LASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVD---AVAHCHCKG---VY 131 + P IV E+ + G L+D I + R EE + D + + H + V Sbjct: 73 ILEPPNYGIVTEYASLGSLYDYI-NSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVI 131 Query: 132 HRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSAA 191 HRDLK N+++ +G LK+ DFG S + + GT ++APEV+ Sbjct: 132 HRDLKSRNVVIAADGVLKICDFGASRFHNHTTHM--SLVGTFPWMAPEVIQSLPV-SETC 188 Query: 192 DIWSCGVILFVILAGYLPFSETDLPGLYRKINAAE--------FSCPPWFSAEVKFLIHR 243 D +S GV+L+ +L +PF L GL E SCP F+ L+H+ Sbjct: 189 DTYSYGVVLWEMLTREVPFK--GLEGLQVAWLVVEKNERLTIPSSCPRSFAE----LLHQ 242 Query: 244 ILDPNPKTRIQIQGI 258 + + K R + I Sbjct: 243 CWEADAKKRPSFKQI 257 >3E3P-A nrPDB Length = 360 Score = 80.1 bits (196), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 75/273 (27%), Positives = 127/273 (46%), Gaps = 31/273 (11%) Query: 6 RRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKI 65 + + +++V R G+GTF V+ + TG +VAIK + + +NR + QI ++++++ Sbjct: 20 KEMDRFQVERMAGQGTFGTVQLGKEKSTGMSVAIKKVIQDPRFRNREL-QIMQDLAVL-- 76 Query: 66 VRHPNIVRLYEVLASPSK-----IY--IVLEFVTGGELFDRIVHKGRLEESES-----RK 113 HPNIV+L + + IY +V+E+V + R + + Sbjct: 77 -HHPNIVQLQSYFYTLGERDRRDIYLNVVMEYVP--DTLHRCCRNYYRRQVAPPPILIKV 133 Query: 114 YFQQLVDAVAHCHCKG--VYHRDLKPENLLLD-TNGNLKVSDFGLSALPQEGVELLRTTC 170 + QL+ ++ H V HRD+KP N+L++ +G LK+ DFG + + C Sbjct: 134 FLFQLIRSIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKLSPSEPNVAYIC 193 Query: 171 GTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCP 230 Y APE++ G + +A DIWS G I ++ G F + G +I CP Sbjct: 194 SR-YYRAPELIFGNQHYTTAVDIWSVGCIFAEMMLGEPIFRGDNSAGQLHEI-VRVLGCP 251 Query: 231 PWFSAEVKFLIHRILDPNPKTRIQIQGIKKDPW 263 S EV R L+P+ T + + K PW Sbjct: 252 ---SREVL----RKLNPS-HTDVDLYNSKGIPW 276 >5TE0-A nrPDB Length = 347 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 91/311 (29%), Positives = 146/311 (46%), Gaps = 51/311 (16%) Query: 13 VGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQI-KREISIMK-IVRHPN 70 V + EG FA V R ++ +K K + N Q+ KREI IM+ + H N Sbjct: 23 VDEVLAEGGFAIVFLVRTSN-----GMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKN 77 Query: 71 IVRLYEV----LASPS--KIYIVLEFVTGGELFDRIVHKGR--LEESESRKYFQQLVDAV 122 IV + ++S ++ I+++F GG++ + + + + E+E + F +AV Sbjct: 78 IVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAV 137 Query: 123 AHCH-CKG-VYHRDLKPENLLLDTNGNLKVSDFGLSA----LPQ-EGV-----ELLRTTC 170 A H CK + HRDLK EN+LL G+ + DFG + PQ EGV E+ + T Sbjct: 138 ARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYT- 196 Query: 171 GTPNYVAPEVLSGQGYDG----SAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAE 226 T +Y APE+++ Y G + ADIW+ G +L+ + LPF E+ + I Sbjct: 197 -TLSYRAPEMVN--LYSGKIITTKADIWALGCLLYKLCYFTLPFGESQV-----AICDGN 248 Query: 227 FSCP--PWFSAEVKFLIHRILDPNPKTRIQIQGI---------KKDPWFRLNYVPIRARE 275 F+ P +S ++ LI +L+P+P R I + K+ P + PI A+ Sbjct: 249 FTIPDNSRYSQDMHCLIRYMLEPDPDKRPDIYQVSYFSFKLLKKECPIPNVQNSPIPAKL 308 Query: 276 EEEVNLDDIRA 286 E V + A Sbjct: 309 PEPVKASEAAA 319 >4Y93-A nrPDB Length = 446 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 53/199 (26%), Positives = 103/199 (51%), Gaps = 9/199 (4%) Query: 15 RTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRL 74 + +G G F VK+ + D VAIK++ + ++ ++ +++ K +M + H +V+L Sbjct: 194 KELGTGQFGVVKYGKWRGQYD-VAIKMIKEGSMSEDEFIEEAK----VMMNLSHEKLVQL 248 Query: 75 YEVLASPSKIYIVLEFVTGGELFDRIVH-KGRLEESESRKYFQQLVDAVAHCHCKGVYHR 133 Y V I+I+ E++ G L + + + R + + + + + +A+ + K HR Sbjct: 249 YGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHR 308 Query: 134 DLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTP-NYVAPEVLSGQGYDGSAAD 192 DL N L++ G +KVSDFG++ + T P + +PEVL + S +D Sbjct: 309 DLAARNCLVNDQGVVKVSDFGMTRYVLDDEYTSSTGSKFPVKWASPEVLMYSKF-SSKSD 367 Query: 193 IWSCGVILFVILA-GYLPF 210 IW+ GV+++ I + G +P+ Sbjct: 368 IWAFGVLMWEIYSLGKMPY 386 >3SXS-A nrPDB Length = 268 Score = 79.3 bits (194), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 54/199 (27%), Positives = 100/199 (50%), Gaps = 9/199 (4%) Query: 15 RTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRL 74 + +G G F VK + D VA+K++ + ++ + D+ +E M + HP +V+ Sbjct: 14 KELGSGQFGVVKLGKWKGQYD-VAVKMIKEGSMSE----DEFFQEAQTMMKLSHPKLVKF 68 Query: 75 YEVLASPSKIYIVLEFVTGGELFDRIVHKGR-LEESESRKYFQQLVDAVAHCHCKGVYHR 133 Y V + IYIV E+++ G L + + G+ LE S+ + + + +A HR Sbjct: 69 YGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQFIHR 128 Query: 134 DLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTP-NYVAPEVLSGQGYDGSAAD 192 DL N L+D + +KVSDFG++ + + P + APEV Y S +D Sbjct: 129 DLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKY-SSKSD 187 Query: 193 IWSCGVILFVILA-GYLPF 210 +W+ G++++ + + G +P+ Sbjct: 188 VWAFGILMWEVFSLGKMPY 206 >6DBN-A nrPDB Length = 316 Score = 79.3 bits (194), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 70/271 (25%), Positives = 122/271 (45%), Gaps = 31/271 (11%) Query: 15 RTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILK---NRMVDQIKREISIMKIVRHPNI 71 R +GEG F KV+ R GDN ++ KS + N + D +K+EI I++ + H NI Sbjct: 41 RDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIAD-LKKEIEILRNLYHENI 99 Query: 72 VRLYEVLASP--SKIYIVLEFVTGGELFDRIV-HKGRLEESESRKYFQQLVDAVAHCHCK 128 V+ + + I +++EF+ G L + + +K ++ + KY Q+ + + + Sbjct: 100 VKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSR 159 Query: 129 GVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVEL--LRTTCGTPNY-VAPEVLSGQG 185 HRDL N+L+++ +K+ DFGL+ + E ++ +P + APE L Sbjct: 160 QYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSK 219 Query: 186 YDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKI------------------NAAEF 227 + A+D+WS GV L +L Y S++ L+ K+ Sbjct: 220 F-YIASDVWSFGVTLHELLT-YCD-SDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRL 276 Query: 228 SCPPWFSAEVKFLIHRILDPNPKTRIQIQGI 258 CPP EV L+ + + P R Q + Sbjct: 277 PCPPNCPDEVYQLMRKCWEFQPSNRTSFQNL 307 >4MYG-A nrPDB Length = 372 Score = 79.0 bits (193), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 61/209 (29%), Positives = 101/209 (48%), Gaps = 23/209 (11%) Query: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAK---STILKNRMVDQIKREISIMKIVRHPNIVR 73 +G G + V A + +G+ VAIK +++ S I R RE+ ++K ++H N++ Sbjct: 51 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAY----RELLLLKHMQHENVIG 106 Query: 74 LYEVLASPSKI------YIVLEFVTGGELFDRIVHKGRLEESESRKYF--QQLVDAVAHC 125 L +V S + Y+V+ F+ +I+ +E SE + + Q++ + + Sbjct: 107 LLDVFTPASSLRNFYDFYLVMPFMQTD--LQKIM---GMEFSEEKIQYLVYQMLKGLKYI 161 Query: 126 HCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQG 185 H GV HRDLKP NL ++ + LK+ DFGL+ + + T Y APEV+ Sbjct: 162 HSAGVVHRDLKPGNLAVNEDCELKILDFGLA---RHADAEMTGYVVTRWYRAPEVILSWM 218 Query: 186 YDGSAADIWSCGVILFVILAGYLPFSETD 214 + DIWS G I+ +L G F D Sbjct: 219 HYNQTVDIWSVGCIMAEMLTGKTLFKGKD 247 >3A4O-X nrPDB Length = 286 Score = 79.0 bits (193), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 53/200 (26%), Positives = 101/200 (50%), Gaps = 10/200 (5%) Query: 15 RTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRL 74 + +G G F +V ++ VA+K + T+ V E ++MK ++H +VRL Sbjct: 19 KRLGAGQFGEVWMGYYNNS-TKVAVKTLKPGTM----SVQAFLEEANLMKTLQHDKLVRL 73 Query: 75 YEVLASPSKIYIVLEFVTGGELFDRIVHK--GRLEESESRKYFQQLVDAVAHCHCKGVYH 132 Y V+ IYI+ E++ G L D + G++ + + Q+ + +A+ K H Sbjct: 74 YAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIH 133 Query: 133 RDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTP-NYVAPEVLSGQGYDGSAA 191 RDL+ N+L+ + K++DFGL+ + ++ R P + APE ++ G + Sbjct: 134 RDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINF-GCFTIKS 192 Query: 192 DIWSCGVILF-VILAGYLPF 210 D+WS G++L+ ++ G +P+ Sbjct: 193 DVWSFGILLYEIVTYGKIPY 212 >2H34-A nrPDB Length = 309 Score = 78.2 bits (191), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 65/248 (26%), Positives = 115/248 (46%), Gaps = 5/248 (2%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 G Y + R +G G V A +T VA+K+M+++ +++RE ++ Sbjct: 34 GPYRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRTRMQREARTAGRLQE 93 Query: 69 PNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCK 128 P++V +++ ++Y+ + + G +L + +G L + +Q+ A+ H Sbjct: 94 PHVVPIHDFGEIDGQLYVDMRLINGVDLAAMLRRQGPLAPPRAVAIVRQIGSALDAAHAA 153 Query: 129 GVYHRDLKPENLLLDTNGNLKVSDFGL-SALPQEGVELLRTTCGTPNYVAPEVLSGQGYD 187 G HRD+KPEN+L+ + + DFG+ SA E + L T GT Y+APE S + + Sbjct: 154 GATHRDVKPENILVSADDFAYLVDFGIASATTDEKLTQLGNTVGTLYYMAPERFS-ESHA 212 Query: 188 GSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAA---EFSCPPWFSAEVKFLIHRI 244 ADI++ +L+ L G P+ L + IN A + P +I R Sbjct: 213 TYRADIYALTCVLYECLTGSPPYQGDQLSVMGAHINQAIPRPSTVRPGIPVAFDAVIARG 272 Query: 245 LDPNPKTR 252 + NP+ R Sbjct: 273 MAKNPEDR 280 >4P5Q-A nrPDB Length = 361 Score = 78.2 bits (191), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 63/228 (27%), Positives = 108/228 (47%), Gaps = 13/228 (5%) Query: 13 VGRTIGEGTFAKVKFAR---NTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 + + +G G F +V R + +VAIK + K R E SIM HP Sbjct: 37 IDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRR--DFLGEASIMGQFDHP 94 Query: 70 NIVRLYEVLASPSKIYIVLEFVTGGELFDRIV--HKGRLEESESRKYFQQLVDAVAHCHC 127 NI+RL V+ + IV E++ G L D + H + + + + + + Sbjct: 95 NIIRLEGVVTKSKPVMIVTEYMENGSL-DSFLRKHDAQFTVIQLVGMLRGIASGMKYLSD 153 Query: 128 KGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTP---NYVAPEVLSGQ 184 G HRDL N+L+++N KVSDFGLS + ++ E TT G + +PE ++ + Sbjct: 154 MGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIAYR 213 Query: 185 GYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAAEFSCPP 231 + SA+D+WS G++L+ +++ G P+ E + + ++ PP Sbjct: 214 KFT-SASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPP 260 >2Y4I-B nrPDB Length = 319 Score = 78.2 bits (191), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 59/216 (27%), Positives = 106/216 (49%), Gaps = 21/216 (9%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 + E+G IG+G F +V R VAI+++ ++++ KRE+ + RH Sbjct: 34 QLEIGELIGKGRFGQVYHGR---WHGEVAIRLIDIERDNEDQL-KAFKREVMAYRQTRHE 89 Query: 70 NIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGR--LEESESRKYFQQLVDAVAHCHC 127 N+V SP + I+ G L+ +V + L+ +++R+ Q++V + + H Sbjct: 90 NVVLFMGACMSPPHLAIITSLCKGRTLYS-VVRDAKIVLDVNKTRQIAQEIVKGMGYLHA 148 Query: 128 KGVYHRDLKPENLLLDTNGNLKVSDFGL---SALPQEG--VELLRTTCGTPNYVAPEVLS 182 KG+ H+DLK +N+ D NG + ++DFGL S + Q G + LR G ++APE++ Sbjct: 149 KGILHKDLKSKNVFYD-NGKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAPEIIR 207 Query: 183 GQGYD--------GSAADIWSCGVILFVILAGYLPF 210 D +D+++ G I + + A PF Sbjct: 208 QLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPF 243 >4XI2-A nrPDB Length = 446 Score = 77.8 bits (190), Expect = 9e-15, Method: Compositional matrix adjust. Identities = 54/199 (27%), Positives = 101/199 (50%), Gaps = 9/199 (4%) Query: 15 RTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRL 74 + +G G F VK+ + D VAIK++ + ++ ++ +++ K +M + H +V+L Sbjct: 193 KELGTGQFGVVKYGKWRGQYD-VAIKMIREGSMSEDEFIEEAK----VMMNLSHEKLVQL 247 Query: 75 YEVLASPSKIYIVLEFVTGGELFDRIVH-KGRLEESESRKYFQQLVDAVAHCHCKGVYHR 133 Y V I+I+ E++ G L + + + R + + + + + +A+ + K HR Sbjct: 248 YGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHR 307 Query: 134 DLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTP-NYVAPEVLSGQGYDGSAAD 192 DL N L++ G +KVSDFGLS + P + PEVL + S +D Sbjct: 308 DLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKF-SSKSD 366 Query: 193 IWSCGVILFVILA-GYLPF 210 IW+ GV+++ I + G +P+ Sbjct: 367 IWAFGVLMWEIYSLGKMPY 385 >6E4F-A nrPDB Length = 290 Score = 77.8 bits (190), Expect = 9e-15, Method: Compositional matrix adjust. Identities = 54/199 (27%), Positives = 101/199 (50%), Gaps = 9/199 (4%) Query: 15 RTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRL 74 + +G G F VK+ + D VAIK++ + ++ ++ +++ K +M + H +V+L Sbjct: 37 KELGTGQFGVVKYGKWRGQYD-VAIKMIKEGSMSEDEFIEEAK----VMMNLSHEKLVQL 91 Query: 75 YEVLASPSKIYIVLEFVTGGELFDRIVH-KGRLEESESRKYFQQLVDAVAHCHCKGVYHR 133 Y V I+I+ E++ G L + + + R + + + + + +A+ + K HR Sbjct: 92 YGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHR 151 Query: 134 DLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTP-NYVAPEVLSGQGYDGSAAD 192 DL N L++ G +KVSDFGLS + P + PEVL + S +D Sbjct: 152 DLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKF-SSKSD 210 Query: 193 IWSCGVILFVILA-GYLPF 210 IW+ GV+++ I + G +P+ Sbjct: 211 IWAFGVLMWEIYSLGKMPY 229 >6O6Q-A nrPDB Length = 335 Score = 77.8 bits (190), Expect = 9e-15, Method: Compositional matrix adjust. Identities = 58/208 (27%), Positives = 101/208 (48%), Gaps = 22/208 (10%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMK-IVRHP 69 YE+ R +G G +++V + + + V IK+ LK +IKREISI+K +V P Sbjct: 43 YEILRKLGRGKYSEVFLGIDLEKREKVVIKV------LKPVKRKKIKREISILKNLVDGP 96 Query: 70 NIVRLYEVLASPSKIYIVLEFVTGGELFDRIVH------KGRLEESESRKYFQQLVDAVA 123 NI+ + +V+ P T G +F+ I + + + R Y +L+ A+ Sbjct: 97 NIIAMLDVVREPQS-------KTPGLIFEHINNIDFRSLYPTFTDYDIRFYMYELLKALD 149 Query: 124 HCHCKGVYHRDLKPENLLLDTNGN-LKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLS 182 + H G+ HRD+KP N+++D + L++ D+GL+ G E + + PE+L Sbjct: 150 YSHSMGIMHRDVKPHNVMIDHDKKLLRLIDWGLAEYYHPGTE-YNVRVASRYFKGPELLV 208 Query: 183 GQGYDGSAADIWSCGVILFVILAGYLPF 210 + D+WS G +L ++ PF Sbjct: 209 DYRLYDYSLDMWSFGCMLASMVFMKEPF 236 >5UIU-A nrPDB Length = 323 Score = 77.4 bits (189), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 65/213 (30%), Positives = 96/213 (45%), Gaps = 14/213 (6%) Query: 14 GRTIGEGTFAKV--KFARNTDTGDNVAIKIMAKST-ILKNRMVDQIKREISIMKIVRHPN 70 G +GEG F V + NT VA+K +A I + Q +EI +M +H N Sbjct: 52 GNKMGEGGFGVVYKGYVNNT----TVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHEN 107 Query: 71 IVRLYEVLASPSKIYIVLEFVTGGELFDRIV---HKGRLEESESRKYFQQLVDAVAHCHC 127 +V L + + +V ++ G L DR+ L K Q + + H Sbjct: 108 LVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHE 167 Query: 128 KGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTT--CGTPNYVAPEVLSGQG 185 HRD+K N+LLD K+SDFGL+ ++ + + T+ GT Y+APE L G+ Sbjct: 168 NHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEI 227 Query: 186 YDGSAADIWSCGVILFVILAGYLPFSETDLPGL 218 S DI+S GV+L I+ G E P L Sbjct: 228 TPKS--DIYSFGVVLLEIITGLPAVDEHREPQL 258 >2W96-B nrPDB Length = 306 Score = 77.4 bits (189), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 60/201 (29%), Positives = 96/201 (47%), Gaps = 14/201 (6%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMK---IV 66 +YE IG G + V AR+ +G VA+K + + + + RE+++++ Sbjct: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPISTV-REVALLRRLEAF 63 Query: 67 RHPNIVRLYEVLASPS-----KIYIVLEFVTGG--ELFDRIVHKGRLEESESRKYFQQLV 119 HPN+VRL +V A+ K+ +V E V D+ G L + +Q + Sbjct: 64 EHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPG-LPAETIKDLMRQFL 122 Query: 120 DAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPE 179 + H + HRDLKPEN+L+ + G +K++DFGL+ + + L T Y APE Sbjct: 123 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMA-LDPVVVTLWYRAPE 181 Query: 180 VLSGQGYDGSAADIWSCGVIL 200 VL Y + D+WS G I Sbjct: 182 VLLQSTY-ATPVDMWSVGCIF 201 >2R2P-A nrPDB Length = 295 Score = 77.4 bits (189), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 65/209 (31%), Positives = 100/209 (47%), Gaps = 13/209 (6%) Query: 13 VGRTIGEGTFAKVKFARNTDTGDN---VAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 + R IG G F +V R G VAIK + K R E SIM HP Sbjct: 26 IERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRR--DFLGEASIMGQFDHP 83 Query: 70 NIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHK--GRLEESESRKYFQQLVDAVAHCHC 127 NI+ L V+ + IV E++ G L D + K G+ + + + + + Sbjct: 84 NIIHLEGVVTKSKPVMIVTEYMENGSL-DTFLKKNDGQFTVIQLVGMLRGISAGMKYLSD 142 Query: 128 KGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTP---NYVAPEVLSGQ 184 G HRDL N+L+++N KVSDFGLS + ++ E TT G + APE ++ + Sbjct: 143 MGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAFR 202 Query: 185 GYDGSAADIWSCGVILF-VILAGYLPFSE 212 + SA+D+WS G++++ V+ G P+ E Sbjct: 203 KFT-SASDVWSYGIVMWEVVSYGERPYWE 230 >4NEU-A nrPDB Length = 333 Score = 77.4 bits (189), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 72/294 (24%), Positives = 129/294 (43%), Gaps = 35/294 (11%) Query: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYE 76 + G F KV + G + + +++ + + E +M +RH +V+L Sbjct: 32 LDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHN--EALLEEAKMMNRLRHSRVVKLLG 89 Query: 77 VLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDLK 136 V+ K +V+E++ G L + + S + ++++ + + H KGV H+DLK Sbjct: 90 VIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHGKGVIHKDLK 149 Query: 137 PENLLLDTNGNLKVSDFGL------SALPQEGVELLRTTCGTPN-------YVAPEVLSG 183 PEN+L+D + ++K++D GL S L E LR GT Y+APE L+ Sbjct: 150 PENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHLND 209 Query: 184 -QGYDGSAADIWSCGVILFVILAGYLPF----SETDLPGLYRKINAAEFS-----CPPWF 233 +D++S V+L+ I A P+ E L + N + CP Sbjct: 210 VNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGNRPDVDDITEYCP--- 266 Query: 234 SAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEVNLDDIRAV 287 E+ L+ + NP+ R GI++ FR P + EE +D++++ Sbjct: 267 -REIISLMKLCWEANPEARPTFPGIEEK--FR----PFYLSQLEESVEEDVKSL 313 >4OLI-A nrPDB Length = 645 Score = 77.4 bits (189), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 59/200 (29%), Positives = 102/200 (51%), Gaps = 13/200 (6%) Query: 15 RTIGEGTFAKVKF----ARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 R +GEG F KV N TG+ VA+K + ++R K+EI I++ + H + Sbjct: 359 RDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHR--SGWKQEIDILRTLYHEH 416 Query: 71 IVRLYEVLASPSK--IYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCK 128 I++ + + +V+E+V G L D + + + ++ + QQ+ + +A+ H + Sbjct: 417 IIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLP-RHSIGLAQLLLFAQQICEGMAYLHSQ 475 Query: 129 GVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVEL--LRTTCGTPNY-VAPEVLSGQG 185 HR+L N+LLD + +K+ DFGL+ EG E +R +P + APE L Sbjct: 476 HYIHRNLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYK 535 Query: 186 YDGSAADIWSCGVILFVILA 205 + A+D+WS GV L+ +L Sbjct: 536 FY-YASDVWSFGVTLYELLT 554 Score = 36.6 bits (83), Expect = 0.021, Method: Compositional matrix adjust. Identities = 59/219 (26%), Positives = 93/219 (42%), Gaps = 31/219 (14%) Query: 61 SIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYF--QQL 118 S+M V H ++ ++ V + +V E+V G L D + + R + K QQL Sbjct: 118 SLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPL-DVWLRRERGHVPMAWKMVVAQQL 176 Query: 119 VDAVAHCHCKGVYHRDLKPENLLL-------DTNGNLKVSD--FGLSALP-QEGVELLRT 168 A+++ K + H ++ N+LL T+ +K+SD GL AL +E VE + Sbjct: 177 ASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERI-- 234 Query: 169 TCGTPNYVAPEVLSGQGYDGSAA-DIWSCGVILF-VILAGYLPF---SETDLPGLY-RKI 222 ++APE L G S A D W G L + G P S ++ Y R+ Sbjct: 235 -----PWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQH 289 Query: 223 NAAEFSCPPWFSAEVKFLIHRILDPNPKTRIQIQGIKKD 261 E SCP ++ L + L P R + I +D Sbjct: 290 RLPEPSCP-----QLATLTSQCLTYEPTQRPSFRTILRD 323 >1BYG-A nrPDB Length = 278 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 63/226 (27%), Positives = 105/226 (46%), Gaps = 20/226 (8%) Query: 15 RTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRL 74 +TIG+G F V G+ VA+K + + + E S+M +RH N+V+L Sbjct: 27 QTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQAFLA-----EASVMTQLRHSNLVQL 79 Query: 75 YEVLAS-PSKIYIVLEFVTGGELFDRIVHKGR--LEESESRKYFQQLVDAVAHCHCKGVY 131 V+ +YIV E++ G L D + +GR L K+ + +A+ + Sbjct: 80 LGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFV 139 Query: 132 HRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSAA 191 HRDL N+L+ + KVSDFGL+ +E T + APE L + + + + Sbjct: 140 HRDLAARNVLVSEDNVAKVSDFGLT---KEASSTQDTGKLPVKWTAPEALREKKFS-TKS 195 Query: 192 DIWSCGVILFVILA-GYLPFSETDLPGLYRKINA-----AEFSCPP 231 D+WS G++L+ I + G +P+ L + ++ A CPP Sbjct: 196 DVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPP 241 >4O2Z-A nrPDB Length = 377 Score = 77.0 bits (188), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 59/198 (29%), Positives = 90/198 (45%), Gaps = 7/198 (3%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 KY + + +G G + + DTG+ V+IK + ++ REI +M+ H Sbjct: 45 SKYTLLKILGMGAYGIACSCLDGDTGEKVSIK-KCRDVFRDVEDGKRVLREIDMMRFFHH 103 Query: 69 PNIVRLYEVLASPSKIYIVLEFV-TGGELFD---RIVHKGR--LEESESRKYFQQLVDAV 122 N++ + +L + Y E V L D +V + R LEES + + Q++ + Sbjct: 104 ENLLNVVNILPPLKREYHSFEDVYVVTPLMDVDMNVVLRSRQVLEESHMQYFVYQILRGL 163 Query: 123 AHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLS 182 + H V HRDLKP NL+ + + LK+ DFGLS L T Y PE+L Sbjct: 164 KYLHSANVAHRDLKPANLVTNISCELKIIDFGLSRSVDVPYSELTDYVITRWYRPPELLL 223 Query: 183 GQGYDGSAADIWSCGVIL 200 +A DIWS G I Sbjct: 224 ENTNYSTAVDIWSVGCIF 241 >1K9A-A nrPDB Length = 450 Score = 76.6 bits (187), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 63/226 (27%), Positives = 105/226 (46%), Gaps = 20/226 (8%) Query: 15 RTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRL 74 +TIG+G F V G+ VA+K + + + E S+M +RH N+V+L Sbjct: 199 QTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQAFLA-----EASVMTQLRHSNLVQL 251 Query: 75 YEVLAS-PSKIYIVLEFVTGGELFDRIVHKGR--LEESESRKYFQQLVDAVAHCHCKGVY 131 V+ +YIV E++ G L D + +GR L K+ + +A+ + Sbjct: 252 LGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFV 311 Query: 132 HRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSAA 191 HRDL N+L+ + KVSDFGL+ +E T + APE L + + + + Sbjct: 312 HRDLAARNVLVSEDNVAKVSDFGLT---KEASSTQDTGKLPVKWTAPEALREKKFS-TKS 367 Query: 192 DIWSCGVILFVILA-GYLPFSETDLPGLYRKINA-----AEFSCPP 231 D+WS G++L+ I + G +P+ L + ++ A CPP Sbjct: 368 DVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPP 413 >2H8H-A nrPDB Length = 535 Score = 76.6 bits (187), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 73/253 (28%), Positives = 116/253 (45%), Gaps = 36/253 (14%) Query: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYE 76 +G+G F +V T VAIK + T+ + +E +MK +RH +V+LY Sbjct: 275 LGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMSPEAFL----QEAQVMKKLRHEKLVQLYA 329 Query: 77 VLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQ--QLVDAVAHCHCKGVY--- 131 V+ S IYIV E+++ G L D + + E+ KY + QLVD A Y Sbjct: 330 VV-SEEPIYIVTEYMSKGSLLDFL-------KGETGKYLRLPQLVDMAAQIASGMAYVER 381 Query: 132 ----HRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTP-NYVAPEVLSGQGY 186 HRDL+ N+L+ N KV+DFGL+ L ++ R P + APE + G Sbjct: 382 MNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEA-ALYGR 440 Query: 187 DGSAADIWSCGVILF-VILAGYLPFSETDLPGLYRK--INAAE----FSCPPWFSAEVKF 239 +D+WS G++L + G +P+ PG+ + ++ E CPP + Sbjct: 441 FTIKSDVWSFGILLTELTTKGRVPY-----PGMVNREVLDQVERGYRMPCPPECPESLHD 495 Query: 240 LIHRILDPNPKTR 252 L+ + P+ R Sbjct: 496 LMCQCWRKEPEER 508 >3EB0-A nrPDB Length = 383 Score = 76.6 bits (187), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 71/258 (27%), Positives = 118/258 (45%), Gaps = 55/258 (21%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 KY +G+T+G G+F V + ++G A+K + + KNR E+ IMK++ H Sbjct: 8 KYSLGKTLGTGSFGIVCEVFDIESGKRFALKKVLQDPRYKNR-------ELDIMKVLDHV 60 Query: 70 NIVRLYE-----------------------------------VLASPSK---IYIVLEFV 91 NI++L + V+ +PS+ + +++E+V Sbjct: 61 NIIKLVDYFYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNVIMEYV 120 Query: 92 --TGGELFDRIVHKGR-LEESESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGN- 147 T ++ + GR + + Y QL AV H G+ HRD+KP+NLL+++ N Sbjct: 121 PDTLHKVLKSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLLVNSKDNT 180 Query: 148 LKVSDFGLSA--LPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILA 205 LK+ DFG + +P E + C Y APE++ G + D+WS G + ++ Sbjct: 181 LKLCDFGSAKKLIPSEPS--VAYICSR-FYRAPELMLGATEYTPSIDLWSIGCVFGELIL 237 Query: 206 GYLPFS-ETDLPGLYRKI 222 G FS ET + L R I Sbjct: 238 GKPLFSGETSIDQLVRII 255 >6F3F-A nrPDB Length = 455 Score = 76.6 bits (187), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 73/253 (28%), Positives = 115/253 (45%), Gaps = 36/253 (14%) Query: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYE 76 +G+G F +V T VAIK + T+ + +E +MK +RH +V+LY Sbjct: 195 LGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMSPEAFL----QEAQVMKKLRHEKLVQLYA 249 Query: 77 VLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQ--QLVDAVAHCHCKGVY--- 131 V+ S IYIV E++ G L D + + E+ KY + QLVD A Y Sbjct: 250 VV-SEEPIYIVTEYMNKGSLLDFL-------KGETGKYLRLPQLVDMSAQIASGMAYVER 301 Query: 132 ----HRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTP-NYVAPEVLSGQGY 186 HRDL+ N+L+ N KV+DFGL+ L ++ R P + APE + G Sbjct: 302 MNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEA-ALYGR 360 Query: 187 DGSAADIWSCGVILF-VILAGYLPFSETDLPGLYRK--INAAE----FSCPPWFSAEVKF 239 +D+WS G++L + G +P+ PG+ + ++ E CPP + Sbjct: 361 FTIKSDVWSFGILLTELTTKGRVPY-----PGMVNREVLDQVERGYRMPCPPECPESLHD 415 Query: 240 LIHRILDPNPKTR 252 L+ + P+ R Sbjct: 416 LMCQCWRKEPEER 428 >3QGY-A nrPDB Length = 286 Score = 75.9 bits (185), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 56/199 (28%), Positives = 95/199 (47%), Gaps = 9/199 (4%) Query: 15 RTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRL 74 + IG G F V + D VAIK + + ++ ++ ++ E +M + HP +V+L Sbjct: 33 QEIGSGQFGLVHLGYWLNK-DKVAIKTIKEGSMSEDDFIE----EAEVMMKLSHPKLVQL 87 Query: 75 YEVLASPSKIYIVLEFVTGGELFDRI-VHKGRLEESESRKYFQQLVDAVAHCHCKGVYHR 133 Y V + I +V EF+ G L D + +G + + +A+ V HR Sbjct: 88 YGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIHR 147 Query: 134 DLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTP-NYVAPEVLSGQGYDGSAAD 192 DL N L+ N +KVSDFG++ + T P + +PEV S Y S +D Sbjct: 148 DLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYS-SKSD 206 Query: 193 IWSCGVILFVILA-GYLPF 210 +WS GV+++ + + G +P+ Sbjct: 207 VWSFGVLMWEVFSEGKIPY 225 >3OMV-A nrPDB Length = 307 Score = 75.9 bits (185), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 52/203 (25%), Positives = 101/203 (49%), Gaps = 10/203 (4%) Query: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYE 76 IG G+F V + GD VA+KI+ K + E+++++ RH NI+ L+ Sbjct: 44 IGSGSFGTV--YKGKWHGD-VAVKIL-KVVDPTPEQFQAFRNEVAVLRKTRHVNIL-LFM 98 Query: 77 VLASPSKIYIVLEFVTGGELFDRI-VHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDL 135 + + IV ++ G L+ + V + + + + +Q + + H K + HRD+ Sbjct: 99 GYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDM 158 Query: 136 KPENLLLDTNGNLKVSDFGLSALPQ--EGVELLRTTCGTPNYVAPEVLSGQGYD--GSAA 191 K N+ L +K+ DFGL+ + G + + G+ ++APEV+ Q + + Sbjct: 159 KSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQS 218 Query: 192 DIWSCGVILFVILAGYLPFSETD 214 D++S G++L+ ++ G LP+S + Sbjct: 219 DVYSYGIVLYELMTGELPYSHIN 241 >4IDT-A nrPDB Length = 356 Score = 75.5 bits (184), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 55/202 (27%), Positives = 97/202 (48%), Gaps = 15/202 (7%) Query: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYE 76 +G G+F +V + TG A+K K R+ E+ + P IV LY Sbjct: 82 LGRGSFGEVHRMEDKQTGFQCAVK--------KVRLEVFRAEELMACAGLTSPRIVPLYG 133 Query: 77 VLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDLK 136 + + I +E + GG L + +G L E + Y Q ++ + + H + + H D+K Sbjct: 134 AVREGPWVNIFMELLEGGSLGQLVKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVK 193 Query: 137 PENLLLDTNG-NLKVSDFGLSALPQE---GVELLRTT--CGTPNYVAPEVLSGQGYDGSA 190 +N+LL ++G + + DFG + Q G +LL GT ++APEV+ G+ D + Sbjct: 194 ADNVLLSSDGSHAALCDFGHAVCLQPDGLGKDLLTGDYIPGTETHMAPEVVLGRSCD-AK 252 Query: 191 ADIWSCGVILFVILAGYLPFSE 212 D+WS ++ +L G P+++ Sbjct: 253 VDVWSSCCMMLHMLNGCHPWTQ 274 >5SYS-A nrPDB Length = 286 Score = 75.5 bits (184), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 72/253 (28%), Positives = 115/253 (45%), Gaps = 36/253 (14%) Query: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYE 76 +G+G F + T VAIK + T+ + +E +MK +RH +V+LY Sbjct: 26 LGQGCFGECWMGTWNGT-TRVAIKTLKPGTMSPEAFL----QEAQVMKKLRHEKLVQLYA 80 Query: 77 VLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQ--QLVDAVAHCHCKGVY--- 131 V+ S IYIV E+++ G L D + + E KY + QLVD A Y Sbjct: 81 VV-SEEPIYIVTEYMSKGSLLDFL-------KGEMGKYLRLPQLVDMAAQIASGMAYVER 132 Query: 132 ----HRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTP-NYVAPEVLSGQGY 186 HRDL+ N+L+ N KV+DFGL+ L ++ R P + APE + G Sbjct: 133 MNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEA-ALYGR 191 Query: 187 DGSAADIWSCGVILF-VILAGYLPFSETDLPGLYRK--INAAE----FSCPPWFSAEVKF 239 +D+WS G++L + G +P+ PG+ + ++ E CPP + Sbjct: 192 FTIKSDVWSFGILLTELTTKGRVPY-----PGMVNREVLDQVERGYRMPCPPECPESLHD 246 Query: 240 LIHRILDPNPKTR 252 L+ + +P+ R Sbjct: 247 LMCQCWRKDPEER 259 >4G3E-A nrPDB Length = 352 Score = 75.5 bits (184), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 57/202 (28%), Positives = 96/202 (47%), Gaps = 15/202 (7%) Query: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYE 76 +G G+F +V ++ TG A+K K R+ E+ + P IV LY Sbjct: 82 VGRGSFGEVHRMKDKQTGFQCAVK--------KVRLEVFRVEELVACAGLSSPRIVPLYG 133 Query: 77 VLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDLK 136 + + I +E + GG L I G L E + Y Q ++ + + H + + H D+K Sbjct: 134 AVREGPWVNIFMELLEGGSLGQLIKQMGCLPEDRALYYLGQALEGLEYLHTRRILHGDVK 193 Query: 137 PENLLLDTNGN-LKVSDFGLSALPQE---GVELLRTTC--GTPNYVAPEVLSGQGYDGSA 190 +N+LL ++G+ + DFG + Q G LL GT ++APEV+ G+ D + Sbjct: 194 ADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPEVVMGKPCD-AK 252 Query: 191 ADIWSCGVILFVILAGYLPFSE 212 DIWS ++ +L G P+++ Sbjct: 253 VDIWSSCCMMLHMLNGCHPWTQ 274 >4E20-A nrPDB Length = 290 Score = 75.5 bits (184), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 59/200 (29%), Positives = 101/200 (50%), Gaps = 13/200 (6%) Query: 15 RTIGEGTFAKVKF----ARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 R +GEG F KV N TG+ VA+K + + ++ +REI I++ + H + Sbjct: 14 RDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGC--GPQLRSGWQREIEILRTLYHEH 71 Query: 71 IVRLYEVLASPSK--IYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCK 128 IV+ + + +V+E+V G L D + + + ++ + QQ+ + +A+ H + Sbjct: 72 IVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYLP-RHCVGLAQLLLFAQQICEGMAYLHAQ 130 Query: 129 GVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVEL--LRTTCGTP-NYVAPEVLSGQG 185 HR L N+LLD + +K+ DFGL+ EG E +R +P + APE L Sbjct: 131 HYIHRALAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKECK 190 Query: 186 YDGSAADIWSCGVILFVILA 205 + A+D+WS GV L+ +L Sbjct: 191 FY-YASDVWSFGVTLYELLT 209 >4PDO-A nrPDB Length = 299 Score = 75.1 bits (183), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 68/231 (29%), Positives = 109/231 (47%), Gaps = 19/231 (8%) Query: 15 RTIGEGTFAKV-KFARNTDTGDN---VAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 + IG G F +V K T +G VAIK + K R VD + E IM H N Sbjct: 40 KVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQR-VDFLG-EAGIMGQFSHHN 97 Query: 71 IVRLYEVLASPSKIYIVLEFVTGGELFDRIVHK--GRLEESESRKYFQQLVDAVAHCHCK 128 I+RL V++ + I+ E++ G L D+ + + G + + + + + Sbjct: 98 IIRLEGVISKYKPMMIITEYMENGAL-DKFLREKDGEFSVLQLVGMLRGIAAGMKYLANM 156 Query: 129 GVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTP---NYVAPEVLSGQG 185 HRDL N+L+++N KVSDFGLS + ++ E TT G + APE +S + Sbjct: 157 NYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYRK 216 Query: 186 YDGSAADIWSCGVILF-VILAGYLPFSETDLPGLYRKIN-----AAEFSCP 230 + SA+D+WS G++++ V+ G P+ E + + IN CP Sbjct: 217 FT-SASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCP 266 >2I6L-A nrPDB Length = 320 Score = 74.7 bits (182), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 64/221 (28%), Positives = 99/221 (44%), Gaps = 25/221 (11%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 +Y + +G G V A + D VAIK K + + V REI I++ + H Sbjct: 12 RYMDLKPLGCGGNGLVFSAVDNDCDKRVAIK---KIVLTDPQSVKHALREIKIIRRLDHD 68 Query: 70 NIVRLYEVLASPS---------------KIYIVLEFVTGGELFDRIVHKGRLEESESRKY 114 NIV+++E+L PS +YIV E++ ++ +G L E +R + Sbjct: 69 NIVKVFEILG-PSGSQLTDDVGSLTELNSVYIVQEYMETD--LANVLEQGPLLEEHARLF 125 Query: 115 FQQLVDAVAHCHCKGVYHRDLKPENLLLDTNG-NLKVSDFGLSALPQEGVE---LLRTTC 170 QL+ + + H V HRDLKP NL ++T LK+ DFGL+ + L Sbjct: 126 MYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGL 185 Query: 171 GTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFS 211 T Y +P +L A D+W+ G I +L G F+ Sbjct: 186 VTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFA 226 >3VN9-A nrPDB Length = 340 Score = 74.7 bits (182), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 69/262 (26%), Positives = 119/262 (45%), Gaps = 14/262 (5%) Query: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYE 76 +G G + V+ R+ +G +A+K + + + + + +IS M+ V P V Y Sbjct: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDIS-MRTVDCPFTVTFYG 117 Query: 77 VLASPSKIYIVLEFVTGG--ELFDRIVHKGR-LEESESRKYFQQLVDAVAHCHCK-GVYH 132 L ++I +E + + + +++ KG+ + E K +V A+ H H K V H Sbjct: 118 ALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIH 177 Query: 133 RDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPE----VLSGQGYDG 188 RD+KP N+L++ G +K+ DFG+S + V G Y+APE L+ +GY Sbjct: 178 RDVKPSNVLINALGQVKMCDFGISGYLVDSVA-KTIDAGCKPYMAPERINPELNQKGY-S 235 Query: 189 SAADIWSCGVILFVILAGYLPFSETDLP--GLYRKINAAEFSCPP-WFSAEVKFLIHRIL 245 +DIWS G+ + + P+ P L + + P FSAE + L Sbjct: 236 VKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCL 295 Query: 246 DPNPKTRIQIQGIKKDPWFRLN 267 N K R + + P+F L+ Sbjct: 296 KKNSKERPTYPELMQHPFFTLH 317 >3FME-A nrPDB Length = 290 Score = 74.7 bits (182), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 69/262 (26%), Positives = 119/262 (45%), Gaps = 14/262 (5%) Query: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYE 76 +G G + V+ R+ +G +A+K + + + + + +IS M+ V P V Y Sbjct: 15 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDIS-MRTVDCPFTVTFYG 73 Query: 77 VLASPSKIYIVLEFVTGG--ELFDRIVHKGR-LEESESRKYFQQLVDAVAHCHCK-GVYH 132 L ++I +E + + + +++ KG+ + E K +V A+ H H K V H Sbjct: 74 ALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIH 133 Query: 133 RDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPE----VLSGQGYDG 188 RD+KP N+L++ G +K+ DFG+S + V G Y+APE L+ +GY Sbjct: 134 RDVKPSNVLINALGQVKMCDFGISGYLVDDVA-KDIDAGCKPYMAPERINPELNQKGY-S 191 Query: 189 SAADIWSCGVILFVILAGYLPFSETDLP--GLYRKINAAEFSCPP-WFSAEVKFLIHRIL 245 +DIWS G+ + + P+ P L + + P FSAE + L Sbjct: 192 VKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCL 251 Query: 246 DPNPKTRIQIQGIKKDPWFRLN 267 N K R + + P+F L+ Sbjct: 252 KKNSKERPTYPELMQHPFFTLH 273 >2Y6O-A nrPDB Length = 291 Score = 73.9 bits (180), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 64/243 (26%), Positives = 112/243 (46%), Gaps = 16/243 (6%) Query: 12 EVGRTIGEGTFAKVKFARNTDTGDN---VAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 ++ + IG G F +V R G VAIK + K R E SIM H Sbjct: 17 KIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRR--DFLSEASIMGQFDH 74 Query: 69 PNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHK--GRLEESESRKYFQQLVDAVAHCH 126 PNI+ L V+ + I+ E++ G L D + K GR + + + + + Sbjct: 75 PNIIHLEGVVTKCKPVMIITEYMENGSL-DAFLRKNDGRFTVIQLVGMLRGIGSGMKYLS 133 Query: 127 CKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTP---NYVAPEVLSG 183 HRDL N+L+++N KVSDFG+S + ++ E TT G + APE ++ Sbjct: 134 DMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAY 193 Query: 184 QGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIH 242 + + SA+D+WS G++++ +++ G P+ + + + I PP + +H Sbjct: 194 RKFT-SASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPP---MDCPIALH 249 Query: 243 RIL 245 +++ Sbjct: 250 QLM 252 >5ZTN-A nrPDB Length = 429 Score = 73.6 bits (179), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 63/208 (30%), Positives = 98/208 (47%), Gaps = 19/208 (9%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 +YEV + IG+G+F +V A + +VA+K++ + R Q EI I++ +R Sbjct: 98 RYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRN----EKRFHRQAAEEIRILEHLRKQ 153 Query: 70 ------NIVRLYEVLASPSKIYIVLEFVTGG--ELFDRIVHKGRLEESESRKYFQQLVDA 121 N++ + E + I + E ++ EL + +G RK+ ++ Sbjct: 154 DKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQG-FSLPLVRKFAHSILQC 212 Query: 122 VAHCHCKGVYHRDLKPENLLLDTNG--NLKVSDFGLSALPQEGVELLRTTCGTPNYVAPE 179 + H + H DLKPEN+LL G +KV DFG S + V T + Y APE Sbjct: 213 LDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRV---YTYIQSRFYRAPE 269 Query: 180 VLSGQGYDGSAADIWSCGVILFVILAGY 207 V+ G Y G D+WS G IL +L GY Sbjct: 270 VILGARY-GMPIDMWSLGCILAELLTGY 296 >2HK5-A nrPDB Length = 270 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 52/212 (24%), Positives = 103/212 (48%), Gaps = 11/212 (5%) Query: 15 RTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRL 74 + +G G F +V A + VA+K M ++ V+ E ++MK ++H +V+L Sbjct: 21 KKLGAGQFGEVWMA-TYNKHTKVAVKTMKPGSM----SVEAFLAEANVMKTLQHDKLVKL 75 Query: 75 YEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESR--KYFQQLVDAVAHCHCKGVYH 132 + V+ IYI+ EF+ G L D + ++ + + Q+ + +A + H Sbjct: 76 HAVVTK-EPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIH 134 Query: 133 RDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTP-NYVAPEVLSGQGYDGSAA 191 RDL+ N+L+ + K++DFGL+ + ++ R P + APE ++ + + Sbjct: 135 RDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFT-IKS 193 Query: 192 DIWSCGVILF-VILAGYLPFSETDLPGLYRKI 222 D+WS G++L ++ G +P+ P + R + Sbjct: 194 DVWSFGILLMEIVTYGRIPYPGMSNPEVIRAL 225 >5X8I-B nrPDB Length = 346 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 77/274 (28%), Positives = 110/274 (40%), Gaps = 56/274 (20%) Query: 9 GKYEVGRTIGEGTFAKV-KFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR 67 +YE+ T+GEG F KV + + G +VA+KI+ +R + + EI +++ + Sbjct: 13 ARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNV----DRYCEAARSEIQVLEHLN 68 Query: 68 --HPN----IVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRL--EESESRKYFQQLV 119 PN V++ E I IV E + G +D I G L RK Q+ Sbjct: 69 TTDPNSTFRCVQMLEWFEHHGHICIVFELL-GLSTYDFIKENGFLPFRLDHIRKMAYQIC 127 Query: 120 DAVAHCHCKGVYHRDLKPENLLLDT-------------------NGNLKVSDFGLSALPQ 160 +V H + H DLKPEN+L N ++KV DFG + Sbjct: 128 KSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDD 187 Query: 161 EGVELLRTTCGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYR 220 E T T +Y APEV+ G+ D+WS G IL G+ F D Sbjct: 188 EHHS---TLVSTRHYRAPEVILALGW-SQPCDVWSIGCILIEYYLGFTVFPTHD------ 237 Query: 221 KINAAEFSCPPWFSAEVKFLIHRILDPNPKTRIQ 254 S E ++ RIL P PK IQ Sbjct: 238 -------------SKEHLAMMERILGPLPKHMIQ 258 >3ALO-A nrPDB Length = 327 Score = 72.8 bits (177), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 59/205 (28%), Positives = 96/205 (46%), Gaps = 16/205 (7%) Query: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYE 76 IG G + V + +G +A+K + +ST+ + + +M+ P IV+ Y Sbjct: 30 IGRGAYGSVNKMVHKPSGQIMAVKRI-RSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYG 88 Query: 77 VLASPSKIYIVLEFVTGGELFDRI------VHKGRLEESESRKYFQQLVDAVAHCHCK-G 129 L +I +E ++ FD+ V + E K V A+ H Sbjct: 89 ALFREGDCWICMELMSTS--FDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKENLK 146 Query: 130 VYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVL----SGQG 185 + HRD+KP N+LLD +GN+K+ DFG+S + + R P Y+APE + S QG Sbjct: 147 IIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRP-YMAPERIDPSASRQG 205 Query: 186 YDGSAADIWSCGVILFVILAGYLPF 210 YD +D+WS G+ L+ + G P+ Sbjct: 206 YD-VRSDVWSLGITLYELATGRFPY 229 >3QUP-A nrPDB Length = 323 Score = 72.8 bits (177), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 70/263 (26%), Positives = 123/263 (46%), Gaps = 23/263 (8%) Query: 10 KYEVGRTIGEGTFAKVKFAR-NTDTGDNVAIKI-MAKSTILKNRMVDQIKREISIMKIVR 67 ++ +GR +G+G F V+ A+ + G V + + M K+ I+ + +++ RE + MK Sbjct: 24 QFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFD 83 Query: 68 HPNIVRLYEV-LASPSK-----IYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDA 121 HP++ +L V L S +K ++L F+ G+L ++ R+ E+ Q LV Sbjct: 84 HPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLL-ASRIGENPFNLPLQTLVRF 142 Query: 122 VAHCHCKGVY-------HRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTP- 173 + C Y HRDL N +L + + V+DFGLS G + R C + Sbjct: 143 MVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSG-DYYRQGCASKL 201 Query: 174 --NYVAPEVLSGQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRK-INAAEFSC 229 ++A E L+ Y +D+W+ GV ++ I+ G P++ + +Y I Sbjct: 202 PVKWLALESLADNLYT-VHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQ 260 Query: 230 PPWFSAEVKFLIHRILDPNPKTR 252 PP EV L+++ +PK R Sbjct: 261 PPECMEEVYDLMYQCWSADPKQR 283 >3NIE-A nrPDB Length = 429 Score = 72.8 bits (177), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 65/242 (26%), Positives = 105/242 (43%), Gaps = 48/242 (19%) Query: 1 MTKKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVD------ 54 + K ++ YE+ IG G++ V A + + NVAIK + NRM + Sbjct: 20 IIKNVKVPDNYEIKHLIGRGSYGYVYLAYDKNANKNVAIKKV-------NRMFEDLIDCK 72 Query: 55 QIKREISIMKIVRHPNIVRLYEV-----LASPSKIYIVLEFVTGG--ELFDRIVHKGRLE 107 +I REI+I+ ++ I+RL+++ L ++YIVLE +LF + L Sbjct: 73 RILREITILNRLKSDYIIRLHDLIIPEDLLKFDELYIVLEIADSDLKKLFKTPIF---LT 129 Query: 108 ESESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVEL-- 165 E + L+ H G+ HRDLKP N LL+ + ++K+ DFGL+ ++ Sbjct: 130 EQHVKTILYNLLLGEKFIHESGIIHRDLKPANCLLNQDCSVKICDFGLARTINSDKDIHI 189 Query: 166 -----------------------LRTTCGTPNYVAPEVLSGQGYDGSAADIWSCGVILFV 202 L + T Y APE++ Q ++ DIWS G I Sbjct: 190 VNDLEEKEENEEPGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTGCIFAE 249 Query: 203 IL 204 +L Sbjct: 250 LL 251 >4PL5-B nrPDB Length = 435 Score = 72.0 bits (175), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 74/273 (27%), Positives = 117/273 (42%), Gaps = 42/273 (15%) Query: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYE 76 +G G + + D D +I+ + +R V Q+ RE HPN++R + Sbjct: 35 LGHGAEGTIVYKGMFDNRDVAVKRILPECFSFADREV-QLLRESD-----EHPNVIRYFC 88 Query: 77 VLASPSKIYIVLEFV--TGGELFDR--IVHKGRLEESESRKYFQQLVDAVAHCHCKGVYH 132 YI +E T E ++ H G E Q +AH H + H Sbjct: 89 TEKDRQFQYIAIELCAATLQEYVEQKDFAHLGL----EPITLLHQTTSGLAHLHSLNIVH 144 Query: 133 RDLKPENLLL---DTNGNLK--VSDFGLS---ALPQEGVELLRTTCGTPNYVAPEVLSGQ 184 RDLKP N+LL + +G +K +SDFGL A+ + GT ++APE+LS Sbjct: 145 RDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSED 204 Query: 185 GYDGS--AADIWSCGVIL-FVILAGYLPFSETDLPGLYRKIN----AAEFSCPPWFSAE- 236 D DI+S G + +VI GY PF ++ L R+ N A C F ++ Sbjct: 205 CKDNPTYTVDIFSAGCVFYYVISEGYHPFGKS----LQRQANILLGACNLDC---FHSDK 257 Query: 237 -----VKFLIHRILDPNPKTRIQIQGIKKDPWF 264 + LI +++ +P+ R + + K P+F Sbjct: 258 HEDVIARELIEKMIAMDPQQRPSAKHVLKHPFF 290 >3QD2-B nrPDB Length = 332 Score = 70.9 bits (172), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 72/276 (26%), Positives = 109/276 (39%), Gaps = 79/276 (28%) Query: 6 RRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMV--DQIKREISIM 63 R + +E + +G G F V A+N N AIK + L NR + +++ RE+ + Sbjct: 3 RYLTDFEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIR----LPNRELAREKVMREVKAL 58 Query: 64 KIVRHPNIVRLYEV--------------------------LASPSK-------------- 83 + HP IVR + L+SPS Sbjct: 59 AKLEHPGIVRYFNAWLETPPEKWQEEMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPF 118 Query: 84 -----------------IYIVLEFVTGGELFDRIVHKGRLEESE---SRKYFQQLVDAVA 123 +YI ++ L D + + LE+ E F Q+ +AV Sbjct: 119 STKNTVGQLQPSSPKVYLYIQMQLCRKENLKDWMNRRCSLEDREHGVCLHIFIQIAEAVE 178 Query: 124 HCHCKGVYHRDLKPENLLLDTNGNLKVSDFGL-SALPQEGVELLRTT-----------CG 171 H KG+ HRDLKP N+ + +KV DFGL +A+ Q+ E T G Sbjct: 179 FLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQVG 238 Query: 172 TPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGY 207 T Y++PE + G Y DI+S G+ILF +L + Sbjct: 239 TKLYMSPEQIHGNNY-SHKVDIFSLGLILFELLYSF 273 >5LPZ-A nrPDB Length = 332 Score = 70.5 bits (171), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 74/242 (30%), Positives = 106/242 (43%), Gaps = 27/242 (11%) Query: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYE 76 IG G F V A D G VAIK + + +R + E+ + ++H N+V L Sbjct: 25 IGSGGFGDVYKAILKD-GSAVAIKKLIHVSGQGDR---EFMAEMETIGKIKHRNLVPLLG 80 Query: 77 VLASPSKIYIVLEFVTGGELFDRIVHKGR-----LEESESRKYFQQLVDAVA--HCHCK- 128 + +V EF+ G L D ++H + L S RK +A H +C Sbjct: 81 YCKVGDERLLVYEFMKYGSLED-VLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHHNCSP 139 Query: 129 GVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELL--RTTCGTPNYVAPEVLSGQGY 186 + HRD+K N+LLD N +VSDFG++ L L T GTP YV PE Q + Sbjct: 140 HIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYY--QSF 197 Query: 187 DGSA-ADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRIL 245 S D++S GV+L +L G P TD P + + + W K I + Sbjct: 198 RCSTKGDVYSYGVVLLELLTGKRP---TDSP------DFGDNNLVGWVKQHAKLRISDVF 248 Query: 246 DP 247 DP Sbjct: 249 DP 250 >3N9X-A nrPDB Length = 432 Score = 70.5 bits (171), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 69/237 (29%), Positives = 103/237 (43%), Gaps = 45/237 (18%) Query: 3 KKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVD------QI 56 K + Y + IG G++ V A + +T NVAIK + NRM + +I Sbjct: 20 KNVHVPDNYIIKHLIGRGSYGYVYLAYDKNTEKNVAIKKV-------NRMFEDLIDCKRI 72 Query: 57 KREISIMKIVRHPNIVRLYEV-----LASPSKIYIVLEFVTGG--ELFDRIVHKGRLEES 109 REI+I+ ++ I+RLY++ L ++YIVLE +LF + L E Sbjct: 73 LREITILNRLKSDYIIRLYDLIIPDDLLKFDELYIVLEIADSDLKKLFKTPIF---LTEE 129 Query: 110 ESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSAL----------- 158 + L+ H G+ HRDLKP N LL+ + ++KV DFGL+ Sbjct: 130 HIKTILYNLLLGENFIHESGIIHRDLKPANCLLNQDCSVKVCDFGLARTINSEKDTNIVN 189 Query: 159 -PQEGVE----------LLRTTCGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVIL 204 +E E L + T Y APE++ Q + DIWS G I +L Sbjct: 190 DLEENEEPGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAELL 246 >1U59-A nrPDB Length = 287 Score = 70.1 bits (170), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 65/225 (28%), Positives = 106/225 (47%), Gaps = 16/225 (7%) Query: 17 IGEGTFAKVK--FARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRL 74 +G G F V+ R +VAIK++ + T + +++ RE IM + +P IVRL Sbjct: 18 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGT--EKADTEEMMREAQIMHQLDNPYIVRL 75 Query: 75 YEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEE---SESRKYFQQLVDAVAHCHCKGVY 131 V + + + +V+E GG L +V G+ EE S + Q+ + + K Sbjct: 76 IGVCQAEA-LMLVMEMAGGGPLHKFLV--GKREEIPVSNVAELLHQVSMGMKYLEEKNFV 132 Query: 132 HRDLKPENLLLDTNGNLKVSDFGLSAL--PQEGVELLRTTCGTP-NYVAPEVLSGQGYDG 188 HRDL N+LL K+SDFGLS + R+ P + APE ++ + + Sbjct: 133 HRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKF-S 191 Query: 189 SAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAAE-FSCPP 231 S +D+WS GV ++ L+ G P+ + P + I + CPP Sbjct: 192 SRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPP 236 >2VWV-A nrPDB Length = 302 Score = 70.1 bits (170), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 67/240 (27%), Positives = 107/240 (44%), Gaps = 26/240 (10%) Query: 8 VGKYEVGRTIGEGTFAKVKFARNTDTGDN---VAIKIMAKSTILKNRMVDQIKREISIMK 64 V ++ IG G F +V R G VAIK + + R + E SIM Sbjct: 15 VSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRR--EFLSEASIMG 72 Query: 65 IVRHPNIVRLYEVLASPSKIYIVLEFVTGGEL--FDRIVHKGRLEESESRKYFQQLVDAV 122 HPNI+RL V+ + + I+ EF+ G L F R+ + G+ + + + + Sbjct: 73 QFEHPNIIRLEGVVTNSMPVMILTEFMENGALDSFLRL-NDGQFTVIQLVGMLRGIASGM 131 Query: 123 AHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPN-----YVA 177 + HRDL N+L+++N KVSDFGLS +E T + A Sbjct: 132 RYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTETSSLGGKIPIRWTA 191 Query: 178 PEVLSGQGYDGSAADIWSCGVILFVILA----GYLPFSETDLPGLYRKINAAE--FSCPP 231 PE ++ + + SA+D WS G++++ +++ Y S D+ INA E + PP Sbjct: 192 PEAIAFRKFT-SASDAWSYGIVMWEVMSFGERPYWDMSNQDV------INAIEQDYRLPP 244 >5LPV-A nrPDB Length = 296 Score = 70.1 bits (170), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 74/242 (30%), Positives = 106/242 (43%), Gaps = 27/242 (11%) Query: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYE 76 IG G F V A D G VAIK + + +R + E+ + ++H N+V L Sbjct: 25 IGSGGFGDVYKAILKD-GSAVAIKKLIHVSGQGDR---EFMAEMETIGKIKHRNLVPLLG 80 Query: 77 VLASPSKIYIVLEFVTGGELFDRIVHKGR-----LEESESRKYFQQLVDAVA--HCHCK- 128 + +V EF+ G L D ++H + L S RK +A H +C Sbjct: 81 YCKVGDERLLVYEFMKYGSLED-VLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHHNCSP 139 Query: 129 GVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELL--RTTCGTPNYVAPEVLSGQGY 186 + HRD+K N+LLD N +VSDFG++ L L T GTP YV PE Q + Sbjct: 140 HIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYY--QSF 197 Query: 187 DGSA-ADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRIL 245 S D++S GV+L +L G P TD P + + + W K I + Sbjct: 198 RCSTKGDVYSYGVVLLELLTGKRP---TDSP------DFGDNNLVGWVKQHAKLRISDVF 248 Query: 246 DP 247 DP Sbjct: 249 DP 250 >3RP9-A nrPDB Length = 458 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 63/233 (27%), Positives = 106/233 (45%), Gaps = 46/233 (19%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILK--NRMVD--QIKREISIMKI 65 +YE+ IG G++ V + D + +++A IL+ ++D +I REI+I+ Sbjct: 54 RYEIRHLIGTGSYGHV-----CEAYDKLEKRVVAIKKILRVFEDLIDCKRILREIAILNR 108 Query: 66 VRHPNIVRLYEVLASPS-----KIYIVLEFVTGG--ELFDRIVHKGRLEESESRKYFQQL 118 + H ++V++ +++ ++Y+VLE +LF V+ L E + L Sbjct: 109 LNHDHVVKVLDIVIPKDVEKFDELYVVLEIADSDFKKLFRTPVY---LTELHIKTLLYNL 165 Query: 119 VDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSAL--------------PQEGVE 164 + V + H G+ HRDLKP N L++ + ++KV DFGL+ P+E Sbjct: 166 LVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFGLARTVDYPENGNSQLPISPREDDM 225 Query: 165 LLRTTCGTPN-------------YVAPEVLSGQGYDGSAADIWSCGVILFVIL 204 L T T N Y APE++ Q A D+WS G I +L Sbjct: 226 NLVTFPHTKNLKRQLTGHVVTRWYRAPELILLQENYTEAIDVWSIGCIFAELL 278 >4LFI-A nrPDB Length = 374 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 44/146 (30%), Positives = 78/146 (53%), Gaps = 7/146 (4%) Query: 68 HPNIVRLYEVLASP-SKI-YIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHC 125 H NI+ L++++ P SK +V E+V + RI++ +L + E R Y +L+ A+ +C Sbjct: 132 HANIIHLFDIIKDPISKTPALVFEYVDNVDF--RILYP-KLTDLEIRFYMFELLKALDYC 188 Query: 126 HCKGVYHRDLKPENLLLD-TNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQ 184 H G+ HRD+KP N+++D N L++ D+GL+ +E + + PE+L Sbjct: 189 HSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNME-YNVRVASRFFKGPELLVDY 247 Query: 185 GYDGSAADIWSCGVILFVILAGYLPF 210 + D+WS G +L ++ PF Sbjct: 248 RMYDYSLDLWSFGTMLASMIFKREPF 273 >2WTK-B nrPDB Length = 373 Score = 69.7 bits (169), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 64/248 (25%), Positives = 111/248 (44%), Gaps = 34/248 (13%) Query: 1 MTKKMRRVGKYEVGRTIGEG--TFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKR 58 M+ + G YE+ IG+G V AR TG+ V ++ + N MV ++ Sbjct: 1 MSSFLPEGGCYELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEAC-SNEMVTFLQG 59 Query: 59 EISIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHK--GRLEESESRKYFQ 116 E+ + K+ HPNIV + +++++V F+ G D I + E Q Sbjct: 60 ELHVSKLFNHPNIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQ 119 Query: 117 QLVDAVAHCHCKGVYHRDLKPENLLLDTNG---------NLKVSDFG-----LSALPQEG 162 ++ A+ + H G HR +K ++L+ +G NL + G + P+ Sbjct: 120 GVLKALDYIHHMGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYS 179 Query: 163 VELLRTTCGTPNYVAPEVLSG--QGYDGSAADIWSCGVILFVILAGYLPFSETDLPG--- 217 V++L +++PEVL QGYD + +DI+S G+ + G++PF D+P Sbjct: 180 VKVLP-------WLSPEVLQQNLQGYD-AKSDIYSVGITACELANGHVPFK--DMPATQM 229 Query: 218 LYRKINAA 225 L K+N Sbjct: 230 LLEKLNGT 237 >2PL0-A nrPDB Length = 289 Score = 69.3 bits (168), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 53/198 (26%), Positives = 94/198 (47%), Gaps = 11/198 (5%) Query: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYE 76 +G G F +V N K+ KS + D E ++MK ++H +VRLY Sbjct: 31 LGAGQFGEVWMGYY-----NGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYA 85 Query: 77 VLASPSKIYIVLEFVTGGELFDRIVHKG--RLEESESRKYFQQLVDAVAHCHCKGVYHRD 134 V+ IYI+ E++ G L D + +L ++ Q+ + +A + HRD Sbjct: 86 VVTQ-EPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRD 144 Query: 135 LKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTP-NYVAPEVLSGQGYDGSAADI 193 L+ N+L+ + K++DFGL+ L ++ R P + APE ++ G +D+ Sbjct: 145 LRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAIN-YGTFTIKSDV 203 Query: 194 WSCGVILF-VILAGYLPF 210 WS G++L ++ G +P+ Sbjct: 204 WSFGILLTEIVTHGRIPY 221 >2DQ7-X nrPDB Length = 283 Score = 69.3 bits (168), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 60/206 (29%), Positives = 96/206 (46%), Gaps = 23/206 (11%) Query: 15 RTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRL 74 + +G G F +V + + VAIK + T+ ++ E IMK ++H +V+L Sbjct: 15 KRLGNGQFGEV-WMGTWNGNTKVAIKTLKPGTMSPESFLE----EAQIMKKLKHDKLVQL 69 Query: 75 YEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKY-FQQLVDAVAHCHCKGVY-- 131 Y V+ S IYIV E++ G L D L++ E R LVD A Y Sbjct: 70 YAVV-SEEPIYIVTEYMNKGSLLDF------LKDGEGRALKLPNLVDMAAQVAAGMAYIE 122 Query: 132 -----HRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTP-NYVAPEVLSGQG 185 HRDL+ N+L+ K++DFGL+ L ++ R P + APE + G Sbjct: 123 RMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEA-ALYG 181 Query: 186 YDGSAADIWSCGVILF-VILAGYLPF 210 +D+WS G++L ++ G +P+ Sbjct: 182 RFTIKSDVWSFGILLTELVTKGRVPY 207 >5B2L-A nrPDB Length = 324 Score = 69.3 bits (168), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 67/236 (28%), Positives = 111/236 (47%), Gaps = 25/236 (10%) Query: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH----PNIV 72 +G GT +V R TG +A+K M +S N+ ++ KR + + +V P IV Sbjct: 25 MGSGTCGQVWKMRFRKTGHVIAVKQMRRSG---NK--EENKRILMDLDVVLKSHDCPYIV 79 Query: 73 RLYEVLASPSKIYIVLEFV-TGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCK-GV 130 + + + + ++I +E + T E + + +G + E K +V A+ + K GV Sbjct: 80 QCFGTFITNTDVFIAMELMGTSAEKLKKRM-QGPIPERILGKMTVAIVKALYYLKEKHGV 138 Query: 131 YHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVL-----SGQG 185 HRD+KP N+LLD G +K+ DFG+S + R+ G Y+APE + + Sbjct: 139 IHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSA-GCAAYMAPERIDPPDPTKPD 197 Query: 186 YDGSAADIWSCGVILFVILAGYLPF--SETDLPGLYRKINAAEFSCPPWFSAEVKF 239 YD AD+WS G+ L + G P+ +TD L + + PP + F Sbjct: 198 YD-IRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEE----PPLLPGHMGF 248 >4XCU-A nrPDB Length = 300 Score = 68.6 bits (166), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 66/275 (24%), Positives = 118/275 (42%), Gaps = 34/275 (12%) Query: 13 VGRTIGEGTFAKVKFAR-------NTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKI 65 +G+ +GEG F +V A D VA+K++ + K+ + D + E+ +MK+ Sbjct: 21 LGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKD-LADLVS-EMEVMKL 78 Query: 66 V-RHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDA--- 121 + RH NI+ L V +Y+++E G L + + + SE F LV Sbjct: 79 IGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGSSEGPLSFPVLVSCAYQ 138 Query: 122 ----VAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPN--- 174 + + + HRDL N+L+ + +K++DFGL+ GV + T N Sbjct: 139 VARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLA----RGVHHIDYYKKTSNGRL 194 Query: 175 ---YVAPEVLSGQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAAE---- 226 ++APE L + Y +D+WS G++L+ I G P+ + L+ + Sbjct: 195 PVKWMAPEALFDRVYT-HQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDR 253 Query: 227 -FSCPPWFSAEVKFLIHRILDPNPKTRIQIQGIKK 260 CPP ++ H P + ++ + K Sbjct: 254 PPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDK 288 >4H1J-A nrPDB Length = 293 Score = 68.6 bits (166), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 67/251 (26%), Positives = 117/251 (46%), Gaps = 19/251 (7%) Query: 13 VGRTIGEGTFAKVK---FARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 + R +GEG F +V + + NVA+K K L N+ ++ E IMK + HP Sbjct: 28 LNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNK--EKFMSEAVIMKNLDHP 85 Query: 70 NIVRLYEVLASPSKIYIVLEFVTGGELFDRIV-HKGRLEESESRKYFQQLVDAVAHCHCK 128 +IV+L ++ +I++E GEL + +K L+ Y Q+ A+A+ Sbjct: 86 HIVKLIGIIEE-EPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESI 144 Query: 129 GVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTP-NYVAPEVLSGQGYD 187 HRD+ N+L+ + +K+ DFGLS ++ + P +++PE ++ + + Sbjct: 145 NCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESINFRRF- 203 Query: 188 GSAADIWSCGVILFVILA-GYLPF---SETDLPGLYRKINAAEFS--CPPWFSAEVKFLI 241 +A+D+W V ++ IL+ G PF D+ G+ K + CPP L+ Sbjct: 204 TTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYT----LM 259 Query: 242 HRILDPNPKTR 252 R D +P R Sbjct: 260 TRCWDYDPSDR 270 >2BUJ-A nrPDB Length = 317 Score = 68.6 bits (166), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 71/267 (26%), Positives = 114/267 (42%), Gaps = 33/267 (12%) Query: 15 RTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVD--QIKREISIMKIVRHPNIV 72 + +GEG F+ V G A+K IL + D + +RE + ++ HPNI+ Sbjct: 35 QKLGEGGFSYVDLVEGLHDGHFYALK-----RILCHEQQDREEAQREADMHRLFNHPNIL 89 Query: 73 RLYEVL----ASPSKIYIVLEFVTGGELF---DRIVHKGR-LEESESRKYFQQLVDAVAH 124 RL + + +++L F G L+ +R+ KG L E + + + Sbjct: 90 RLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFLTEDQILWLLLGICRGLEA 149 Query: 125 CHCKGVYHRDLKPENLLLDTNGNLKVSDFG---LSALPQEGVELLRTT-------CGTPN 174 H KG HRDLKP N+LL G + D G + + EG T C T + Sbjct: 150 IHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALTLQDWAAQRC-TIS 208 Query: 175 YVAPEVLSGQGYD--GSAADIWSCGVILFVILAGYLP----FSETDLPGLYRKINAAEFS 228 Y APE+ S Q + D+WS G +L+ ++ G P F + D L + N Sbjct: 209 YRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPYDMVFQKGDSVALAVQ-NQLSIP 267 Query: 229 CPPWFSAEVKFLIHRILDPNPKTRIQI 255 P S+ + L++ ++ +P R I Sbjct: 268 QSPRHSSALWQLLNSMMTVDPHQRPHI 294 >2A1A-B nrPDB Length = 284 Score = 67.8 bits (164), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 74/276 (26%), Positives = 123/276 (44%), Gaps = 50/276 (18%) Query: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYE 76 IG G F +V A++ G IK + + ++ +RE+ + + H NIV Sbjct: 19 IGSGGFGQVFKAKHRIDGKTYVIKRVKYNN-------EKAEREVKALAKLDHVNIVHYNG 71 Query: 77 VL-------------ASPSK---IYIVLEFVTGGELFDRIVHKGR---LEESESRKYFQQ 117 +S SK ++I +EF G L ++ + K R L++ + + F+Q Sbjct: 72 CWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTL-EQWIEKRRGEKLDKVLALELFEQ 130 Query: 118 LVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGL-SALPQEGVELLRT-TCGTPNY 175 + V + H K + +RDLKP N+ L +K+ DFGL ++L +G RT + GT Y Sbjct: 131 ITKGVDYIHSKKLINRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGK---RTRSKGTLRY 187 Query: 176 VAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSA 235 ++PE +S Q Y G D+++ G+IL +L + F +F+ Sbjct: 188 MSPEQISSQDY-GKEVDLYALGLILAELLH----------------VCDTAFETSKFFTD 230 Query: 236 EVKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVPI 271 +I I D KT +Q + + K P R N I Sbjct: 231 LRDGIISDIFDKKEKTLLQ-KLLSKKPEDRPNTSEI 265 >1AD5-A nrPDB Length = 438 Score = 67.8 bits (164), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 52/212 (24%), Positives = 101/212 (47%), Gaps = 21/212 (9%) Query: 15 RTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRL 74 + +G G F +V A + VA+K M ++ V+ E ++MK ++H +V+L Sbjct: 188 KKLGAGQFGEVWMA-TYNKHTKVAVKTMKPGSM----SVEAFLAEANVMKTLQHDKLVKL 242 Query: 75 YEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESR--KYFQQLVDAVAHCHCKGVYH 132 + V+ + IYI+ EF+ G L D + ++ + + Q+ + +A + H Sbjct: 243 HAVV-TKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIH 301 Query: 133 RDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTP-NYVAPEVLSGQGYDGSAA 191 RDL+ N+L+ + K++DFGL+ R P + APE ++ + + Sbjct: 302 RDLRAANILVSASLVCKIADFGLA----------RVGAKFPIKWTAPEAINFGSFT-IKS 350 Query: 192 DIWSCGVILF-VILAGYLPFSETDLPGLYRKI 222 D+WS G++L ++ G +P+ P + R + Sbjct: 351 DVWSFGILLMEIVTYGRIPYPGMSNPEVIRAL 382 >5XVU-A nrPDB Length = 332 Score = 67.8 bits (164), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 50/211 (23%), Positives = 98/211 (46%), Gaps = 14/211 (6%) Query: 4 KMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIM 63 + + +YE+ + IG G +++V +T+ + A + + + + Sbjct: 26 QWNKPNRYEIMKKIGRGKYSEVFNGYDTECN-----RPCAIKVLKPVKKKKIKREIKILQ 80 Query: 64 KIVRHPNIVRLYEVLASP--SKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDA 121 + PNI++L +++ P ++ E++ D + + + R Y Q++ A Sbjct: 81 NLNGGPNIIKLLDIVKDPVTKTPSLIFEYINN---IDFKTLYPKFTDKDIRYYIYQILKA 137 Query: 122 VAHCHCKGVYHRDLKPENLLLD-TNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEV 180 + +CH +G+ HRD+KP N+++D N +++ +GL+ G E + Y PE+ Sbjct: 138 LDYCHSQGIMHRDVKPHNIMIDHENRQIRLISWGLAEFYHPGQE-YNVRVASRYYKGPEL 196 Query: 181 LSG-QGYDGSAADIWSCGVILFVILAGYLPF 210 L Q YD S DIWS G +L ++ PF Sbjct: 197 LIDLQLYDYS-LDIWSLGCMLAGMIFKKEPF 226 >4CRL-A nrPDB Length = 406 Score = 67.8 bits (164), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 45/166 (27%), Positives = 80/166 (48%), Gaps = 17/166 (10%) Query: 58 REISIMKIVRHPNIVRLYEVLASPS--KIYIVLEFVTGGELFDRIVHKG--------RLE 107 REI++++ ++HPN++ L +V S + K++++ ++ H+ +L Sbjct: 68 REIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLP 127 Query: 108 ESESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLL----DTNGNLKVSDFGLSAL---PQ 160 + Q++D + + H V HRDLKP N+L+ G +K++D G + L P Sbjct: 128 RGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPL 187 Query: 161 EGVELLRTTCGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAG 206 + + L T Y APE+L G + A DIW+ G I +L Sbjct: 188 KPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTS 233 >5TOS-A nrPDB Length = 395 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 65/216 (30%), Positives = 99/216 (45%), Gaps = 39/216 (18%) Query: 17 IGEGTFAKVKFARNTD----------TGDNVAIKIMAKSTILKNRMVDQIKREISIMKIV 66 IGEG F V F D TG +A+K + + +R + EI+ + + Sbjct: 73 IGEGGFGCV-FKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHR---EWLTEINYLGQL 128 Query: 67 RHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQL-------- 118 HPN+V+L +V EF+ G L + + +G YF+ L Sbjct: 129 SHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRG--------AYFKPLPWFLRVNV 180 Query: 119 -VDAVA-----HCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLS-ALPQEGVELLRT-TC 170 +DA H V +RD+K N+LLD + N K+SDFGL+ P + + T Sbjct: 181 ALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVM 240 Query: 171 GTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAG 206 GT Y APE +S G+ + +D++S GV+L IL+G Sbjct: 241 GTYGYAAPEYMS-SGHLNARSDVYSFGVLLLEILSG 275 >6HV0-A nrPDB Length = 416 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 73/270 (27%), Positives = 117/270 (43%), Gaps = 36/270 (13%) Query: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYE 76 +G G + + D D +I+ + +R V Q+ RE HPN++R + Sbjct: 16 LGHGAEGTIVYRGMFDNRDVAVKRILPECFSFADREV-QLLRESD-----EHPNVIRYFC 69 Query: 77 VLASPSKIYIVLEFV--TGGELFDR--IVHKGRLEESESRKYFQQLVDAVAHCHCKGVYH 132 YI +E T E ++ H G E QQ +AH H + H Sbjct: 70 TEKDRQFQYIAIELCAATLQEYVEQKDFAHLGL----EPITLLQQTTSGLAHLHSLNIVH 125 Query: 133 RDLKPENLLL---DTNGNLK--VSDFGLS---ALPQEGVELLRTTCGTPNYVAPEVLSGQ 184 RDLKP N+L+ + +G +K +SDFGL A+ + GT ++APE+LS Sbjct: 126 RDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSED 185 Query: 185 GYDGS--AADIWSCGVIL-FVILAGYLPFSETDLPGLYRKIN----AAEFSC-PPWFSAE 236 + DI+S G + +VI G PF ++ L R+ N A C P + Sbjct: 186 CKENPTYTVDIFSAGCVFYYVISEGSHPFGKS----LQRQANILLGACSLDCLHPEKHED 241 Query: 237 V--KFLIHRILDPNPKTRIQIQGIKKDPWF 264 V + LI +++ +P+ R + + K P+F Sbjct: 242 VIARELIEKMIAMDPQKRPSAKHVLKHPFF 271 >3UIU-A nrPDB Length = 306 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 57/193 (29%), Positives = 93/193 (48%), Gaps = 27/193 (13%) Query: 84 IYIVLEFVTGGELFDRIVHKGR---LEESESRKYFQQLVDAVAHCHCKGVYHRDLKPENL 140 ++I +EF G L ++ + K R L++ + + F+Q+ V + H K + HRDLKP N+ Sbjct: 109 LFIQMEFCDKGTL-EQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNI 167 Query: 141 LLDTNGNLKVSDFGL-SALPQEGVELLRT-TCGTPNYVAPEVLSGQGYDGSAADIWSCGV 198 L +K+ DFGL ++L +G RT + GT Y++PE +S Q Y G D+++ G+ Sbjct: 168 FLVDTKQVKIGDFGLVTSLKNDGK---RTRSKGTLRYMSPEQISSQDY-GKEVDLYALGL 223 Query: 199 ILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILDPNPKTRIQIQGI 258 IL +L + F +F+ +I I D KT +Q + + Sbjct: 224 ILAELLH----------------VCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQ-KLL 266 Query: 259 KKDPWFRLNYVPI 271 K P R N I Sbjct: 267 SKKPEDRPNTSEI 279 >2OZO-A nrPDB Length = 613 Score = 67.0 bits (162), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 66/235 (28%), Positives = 110/235 (46%), Gaps = 16/235 (6%) Query: 17 IGEGTFAKVKFA--RNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRL 74 +G G F V+ R +VAIK++ + T + +++ RE IM + +P IVRL Sbjct: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGT--EKADTEEMMREAQIMHQLDNPYIVRL 401 Query: 75 YEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEE---SESRKYFQQLVDAVAHCHCKGVY 131 V + + + +V+E GG L +V G+ EE S + Q+ + + K Sbjct: 402 IGVCQAEA-LMLVMEMAGGGPLHKFLV--GKREEIPVSNVAELLHQVSMGMKYLEEKNFV 458 Query: 132 HRDLKPENLLLDTNGNLKVSDFGLSAL--PQEGVELLRTTCGTP-NYVAPEVLSGQGYDG 188 HR+L N+LL K+SDFGLS + R+ P + APE ++ + + Sbjct: 459 HRNLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFS- 517 Query: 189 SAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAAE-FSCPPWFSAEVKFLI 241 S +D+WS GV ++ L+ G P+ + P + I + CPP E+ L+ Sbjct: 518 SRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALM 572 >2QKW-B nrPDB Length = 321 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 69/255 (27%), Positives = 128/255 (50%), Gaps = 28/255 (10%) Query: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYE 76 IG G F KV D G VA+K + T ++ +++ + EI + RHP++V L Sbjct: 47 IGHGVFGKVYKGVLRD-GAKVALK---RRTPESSQGIEEFETEIETLSFCRHPHLVSLIG 102 Query: 77 VLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQL------VDAVAHCHCKGV 130 +++ ++ +++ G L R ++ L + S + Q+L + + H + + Sbjct: 103 FCDERNEMILIYKYMENGNL-KRHLYGSDLP-TMSMSWEQRLEICIGAARGLHYLHTRAI 160 Query: 131 YHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTC-----GTPNYVAPEVLSGQG 185 HRD+K N+LLD N K++DFG+S ++G EL +T GT Y+ PE +G Sbjct: 161 IHRDVKSINILLDENFVPKITDFGIS---KKGTELDQTHLSTVVKGTLGYIDPEYFI-KG 216 Query: 186 YDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRIL 245 +D++S GV+LF +L ++ LP +N AE++ + +++ +I+ Sbjct: 217 RLTEKSDVYSFGVVLFEVLCARSAIVQS-LP--REMVNLAEWAVESHNNGQLE----QIV 269 Query: 246 DPNPKTRIQIQGIKK 260 DPN +I+ + ++K Sbjct: 270 DPNLADKIRPESLRK 284 >5Y86-A nrPDB Length = 588 Score = 66.2 bits (160), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 60/216 (27%), Positives = 104/216 (48%), Gaps = 21/216 (9%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 +YEV + IG+G+F +V + VA+K++ + R Q EI I++ ++ Sbjct: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRN----EKRFHRQAAEEIRILEHLKKQ 263 Query: 70 ------NIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESES---RKYFQQLVD 120 N++ + E + + + E ++ +L++ ++ K + + RK+ Q ++ Sbjct: 264 DKTGSMNVIHMLESFTFRNHVCMAFELLSI-DLYE-LIKKNKFQGFSVQLVRKFAQSILQ 321 Query: 121 AVAHCHCKGVYHRDLKPENLLLDTNG--NLKVSDFGLSALPQEGVELLRTTCGTPNYVAP 178 ++ H + H DLKPEN+LL +G + KV DFG S + L T + Y AP Sbjct: 322 SLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFE---YQKLYTYIQSRFYRAP 378 Query: 179 EVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETD 214 E++ G Y + DIWS G IL +L G F D Sbjct: 379 EIILGSRYS-TPIDIWSFGCILAELLTGQPLFPGED 413 >5U6B-A nrPDB Length = 307 Score = 65.9 bits (159), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 73/289 (25%), Positives = 129/289 (44%), Gaps = 25/289 (8%) Query: 10 KYEVGRTIGEGTFAKVKFAR--NTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR 67 K +G+T+GEG F V + D+ VA+K M + ++ + D + E MK Sbjct: 24 KVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLS-EAVCMKEFD 82 Query: 68 HPNIVRLYEVL-------ASPSKIYIVLEFVTGGELFDRIVHKGRLEESESR-------K 113 HPN++RL V + P+ + ++L F+ G+L +++ RL + K Sbjct: 83 HPNVMRLIGVCFQGSERESFPAPV-VILPFMKHGDLHSFLLY-SRLGDQPVYLPTQMLVK 140 Query: 114 YFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEG--VELLRTTCG 171 + + + + K HRDL N +L+ N ++ V+DFGLS G R Sbjct: 141 FMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKM 200 Query: 172 TPNYVAPEVLSGQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAAEFSCP 230 ++A E L+ + Y S +D+WS GV ++ I G P+ + +Y + Sbjct: 201 PVKWIAIESLADRVYT-SKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQ 259 Query: 231 PWFSAEVKF-LIHRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEE 278 P + + L+ R + NP+ R +++D L +P A+E +E Sbjct: 260 PADCLDGLYALMSRCWELNPQDRPSFTELREDLENTLKALP-PAQEPDE 307 >5L6P-A nrPDB Length = 298 Score = 65.5 bits (158), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 66/240 (27%), Positives = 105/240 (43%), Gaps = 26/240 (10%) Query: 8 VGKYEVGRTIGEGTFAKVKFARNTDTGDN---VAIKIMAKSTILKNRMVDQIKREISIMK 64 V ++ IG G F +V R G VAIK + + R E SIM Sbjct: 18 VSCVKIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQRR--DFLSEASIMG 75 Query: 65 IVRHPNIVRLYEVLASPSKIYIVLEFVTGGEL--FDRIVHKGRLEESESRKYFQQLVDAV 122 HPNI+RL V+ + I+ EF+ L F R+ + G+ + + + + Sbjct: 76 QFDHPNIIRLEGVVTKSRPVMILTEFMENCALDSFLRL-NDGQFTVIQLVGMLRGIAAGM 134 Query: 123 AHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSAL----PQEGVELLRTTCGTP-NYVA 177 + HRDL N+L+++N KVSDFGLS P + P + A Sbjct: 135 KYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTA 194 Query: 178 PEVLSGQGYDGSAADIWSCGVILFVILA----GYLPFSETDLPGLYRKINAAE--FSCPP 231 PE ++ + + SA+D+WS G++++ +++ Y S D+ INA E + PP Sbjct: 195 PEAIAYRKFT-SASDVWSYGIVMWEVMSYGERPYWDMSNQDV------INAVEQDYRLPP 247 >6FYV-A nrPDB Length = 337 Score = 65.5 bits (158), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 75/287 (26%), Positives = 114/287 (39%), Gaps = 58/287 (20%) Query: 9 GKYEVGRTIGEGTFAKV-KFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR 67 +YE+ T+GEG F KV + + G +VA+KI+ R + + EI +++ + Sbjct: 14 ARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNV----GRYREAARSEIQVLEHLN 69 Query: 68 --HPN----IVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRL--EESESRKYFQQLV 119 PN V++ E + IV E + G +D I L + R+ Q+ Sbjct: 70 STDPNSVFRCVQMLEWFDHHGHVCIVFELL-GLSTYDFIKENSFLPFQIDHIRQMAYQIC 128 Query: 120 DAVAHCHCKGVYHRDLKPENLLLD-------------------TNGNLKVSDFGLSALPQ 160 ++ H + H DLKPEN+L N ++KV DFG + Sbjct: 129 QSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDD 188 Query: 161 EGVELLRTTCGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYR 220 E T T +Y APEV+ G+ D+WS G IL G+ F D Sbjct: 189 EHHS---TLVSTRHYRAPEVILALGW-SQPCDVWSIGCILIEYYLGFTVFQTHD------ 238 Query: 221 KINAAEFSCPPWFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLN 267 S E ++ RIL P P+ IQ +K +F N Sbjct: 239 -------------SKEHLAMMERILGPIPQH--MIQKTRKRKYFHHN 270 >2RIO-A nrPDB Length = 434 Score = 65.5 bits (158), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 67/233 (28%), Positives = 104/233 (44%), Gaps = 37/233 (15%) Query: 68 HPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESE--SRKY-----FQQLVD 120 HPN++R Y + +YI LE + L D + K +E+ ++Y +Q+ Sbjct: 68 HPNVIRYYCSETTDRFLYIALE-LCNLNLQDLVESKNVSDENLKLQKEYNPISLLRQIAS 126 Query: 121 AVAHCHCKGVYHRDLKPENLLLDTNG-----------NLK--VSDFGLSALPQEGVELLR 167 VAH H + HRDLKP+N+L+ T+ NL+ +SDFGL G R Sbjct: 127 GVAHLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFR 186 Query: 168 TT----CGTPNYVAPEVLSGQGYDGS------AADIWSCGVILFVILA-GYLPFSE--TD 214 T GT + APE+L + + DI+S G + + IL+ G PF + + Sbjct: 187 TNLNNPSGTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPFGDKYSR 246 Query: 215 LPGLYRKI-NAAEFSCPPWFS--AEVKFLIHRILDPNPKTRIQIQGIKKDPWF 264 + R I + E C S AE LI +++D +P R + + P F Sbjct: 247 ESNIIRGIFSLDEMKCLHDRSLIAEATDLISQMIDHDPLKRPTAMKVLRHPLF 299 >2PSQ-A nrPDB Length = 370 Score = 65.5 bits (158), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 56/222 (25%), Positives = 101/222 (45%), Gaps = 29/222 (13%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDN-------VAIKIMAKSTILKNRMVDQIKREISI 62 K +G+ +GEG F +V A + VA+K++ K+ + + E+ + Sbjct: 82 KLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKD--LSDLVSEMEM 139 Query: 63 MKIV-RHPNIVRLYEVLASPSKIYIVLEFVTGGEL--FDRIVHKGRLEES-------ESR 112 MK++ +H NI+ L +Y+++E+ + G L + R +E S E + Sbjct: 140 MKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQ 199 Query: 113 KYFQQLVD-------AVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVEL 165 F+ LV + + + HRDL N+L+ N +K++DFGL+ Sbjct: 200 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY 259 Query: 166 LRTTCG--TPNYVAPEVLSGQGYDGSAADIWSCGVILFVILA 205 +TT G ++APE L + Y +D+WS GV+++ I Sbjct: 260 KKTTNGRLPVKWMAPEALFDRVY-THQSDVWSFGVLMWEIFT 300 >3PLS-A nrPDB Length = 298 Score = 65.5 bits (158), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 57/208 (27%), Positives = 98/208 (47%), Gaps = 9/208 (4%) Query: 15 RTIGEGTFAKVKFARNTDTGDN-VAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVR 73 R IG+G F V D N + I + S I + + V+ RE +M+ + HPN++ Sbjct: 27 RVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLNHPNVLA 86 Query: 74 LYEVLASPSKI-YIVLEFVTGGELFDRIVHKGRLEESESRKYFQ-QLVDAVAHCHCKGVY 131 L ++ P + +++L ++ G+L I R + F Q+ + + + Sbjct: 87 LIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLAEQKFV 146 Query: 132 HRDLKPENLLLDTNGNLKVSDFGLS--ALPQE--GVELLRTTCGTPNYVAPEVLSGQGYD 187 HRDL N +LD + +KV+DFGL+ L +E V+ R + A E L + Sbjct: 147 HRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWTALESLQTYRFT 206 Query: 188 GSAADIWSCGVILFVILA-GYLPFSETD 214 + +D+WS GV+L+ +L G P+ D Sbjct: 207 -TKSDVWSFGVLLWELLTRGAPPYRHID 233 >5AMN-A nrPDB Length = 299 Score = 65.5 bits (158), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 53/208 (25%), Positives = 98/208 (47%), Gaps = 16/208 (7%) Query: 13 VGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIK---REISIMKIVRHP 69 +G+T+GEG F KV A +A + +N +++ E +++K V HP Sbjct: 27 LGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHP 86 Query: 70 NIVRLYEVLASPSKIYIVLEFVTGGELF-----DRIVHKGRLEE-----SESRKYFQQLV 119 ++++LY + + +++E+ G L R V G +E + + Q+ Sbjct: 87 HVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYPDERALTMGDLISFAWQIS 146 Query: 120 DAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLS-ALPQEGVELLRTTCGTP-NYVA 177 + + + HRDL N+L+ +K+SDFGLS + +E + R+ P ++A Sbjct: 147 QGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMA 206 Query: 178 PEVLSGQGYDGSAADIWSCGVILFVILA 205 E L Y + +D+WS GV+L+ I+ Sbjct: 207 IESLFDHIYT-TQSDVWSFGVLLWEIVT 233 >5U6C-A nrPDB Length = 315 Score = 65.1 bits (157), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 59/216 (27%), Positives = 97/216 (44%), Gaps = 21/216 (9%) Query: 13 VGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKN---RMVDQIKREISIMKIVRHP 69 +G+ +GEG F V N D ++K+ K+ L N R +++ E + MK HP Sbjct: 40 LGKILGEGEFGSV-MEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHP 98 Query: 70 NIVRLYEVLASPS-----KIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVD---- 120 N++RL V S K ++L F+ G+L +++ RLE Q L+ Sbjct: 99 NVMRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYS-RLETGPKHIPLQTLLKFMVD 157 Query: 121 ---AVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEG--VELLRTTCGTPNY 175 + + + HRDL N +L + + V+DFGLS G R + Sbjct: 158 IALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKW 217 Query: 176 VAPEVLSGQGYDGSAADIWSCGVILFVILA-GYLPF 210 +A E L+ + Y S +D+W+ GV ++ I G P+ Sbjct: 218 IAIESLADRVYT-SKSDVWAFGVTMWEIATRGMTPY 252 >1JPA-A nrPDB Length = 312 Score = 64.7 bits (156), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 55/210 (26%), Positives = 95/210 (45%), Gaps = 15/210 (7%) Query: 12 EVGRTIGEGTFAKVKFARNTDTGDN---VAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 ++ + IG G F +V G VAIK + K R E SIM H Sbjct: 36 KIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRR--DFLSEASIMGQFDH 93 Query: 69 PNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHK--GRLEESESRKYFQQLVDAVAHCH 126 PN++ L V+ + + I+ EF+ G L D + + G+ + + + + + Sbjct: 94 PNVIHLEGVVTKSTPVMIITEFMENGSL-DSFLRQNDGQFTVIQLVGMLRGIAAGMKYLA 152 Query: 127 CKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPN-----YVAPEVL 181 HRDL N+L+++N KVSDFGLS ++ T + APE + Sbjct: 153 DMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAI 212 Query: 182 SGQGYDGSAADIWSCGVILFVILA-GYLPF 210 + + SA+D+WS G++++ +++ G P+ Sbjct: 213 QYRKFT-SASDVWSYGIVMWEVMSYGERPY 241 >5WNO-A nrPDB Length = 330 Score = 64.7 bits (156), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 59/248 (23%), Positives = 110/248 (44%), Gaps = 9/248 (3%) Query: 12 EVGRTIGEGTFAKVKFA--RNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 ++ + +G G F V FA NV I + K D++ E + M +RH Sbjct: 25 KLDKKLGAGAFGTV-FAGIYYPKRAKNVKIPVAIKVFQTDQSQTDEMLEEATNMFRLRHD 83 Query: 70 NIVRLYEVLASPSKIYIVLEFVTGGELFDRI-VHKGRLEESESRKYFQQLVDAVAHCHCK 128 N++++ + IV + G L + + +HK L E Y Q+ + + + Sbjct: 84 NLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGMQYLEKQ 143 Query: 129 GVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCG--TPNYVAPEVLSGQGY 186 V HRDL N+L+ +++++DFGLS + + + + G ++A E+ S Y Sbjct: 144 RVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIEIFSKHCY 203 Query: 187 DGSAADIWSCGVILF-VILAGYLPFSETDLPGLYRKI-NAAEFSCPPWFSAEVKFLIHRI 244 A+D+W+ GV + +I G P+ ++ + + S PP S ++ + R Sbjct: 204 T-HASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQPPNCSQDLYQELLRC 262 Query: 245 LDPNPKTR 252 +PK+R Sbjct: 263 WMADPKSR 270 >3UIM-A nrPDB Length = 326 Score = 64.7 bits (156), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 55/203 (27%), Positives = 93/203 (45%), Gaps = 12/203 (5%) Query: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYE 76 +G G F KV R D G VA+K + + + Q + E+ ++ + H N++RL Sbjct: 38 LGRGGFGKVYKGRLAD-GTLVAVKRLKEERTQGGEL--QFQTEVEMISMAVHRNLLRLRG 94 Query: 77 VLASPSKIYIVLEFVTGGE----LFDRIVHKGRLEESESRKYFQQLVDAVA--HCHCK-G 129 +P++ +V ++ G L +R + L+ + ++ +A H HC Sbjct: 95 FCMTPTERLLVYPYMANGSVASCLRERPESQPPLDWPKRQRIALGSARGLAYLHDHCDPK 154 Query: 130 VYHRDLKPENLLLDTNGNLKVSDFGLSALPQ-EGVELLRTTCGTPNYVAPEVLSGQGYDG 188 + HRD+K N+LLD V DFGL+ L + + GT ++APE LS G Sbjct: 155 IIHRDVKAANILLDEEFEAVVGDFGLAKLMDYKDTHVTTAVRGTIGHIAPEYLS-TGKSS 213 Query: 189 SAADIWSCGVILFVILAGYLPFS 211 D++ GV+L ++ G F Sbjct: 214 EKTDVFGYGVMLLELITGQRAFD 236 >1FVR-A nrPDB Length = 327 Score = 64.3 bits (155), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 68/227 (29%), Positives = 103/227 (45%), Gaps = 26/227 (11%) Query: 17 IGEGTFAKVKFARNTDTG--DNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRL 74 IGEG F +V AR G + AIK M K K+ D + K+ HPNI+ L Sbjct: 33 IGEGNFGQVLKARIKKDGLRMDAAIKRM-KEYASKDDHRDFAGELEVLCKLGHHPNIINL 91 Query: 75 YEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESE----------SRKYFQQLVDAVA- 123 +Y+ +E+ G L D + K R+ E++ S QQL+ A Sbjct: 92 LGACEHRGYLYLAIEYAPHGNLLD-FLRKSRVLETDPAFAIANSTASTLSSQQLLHFAAD 150 Query: 124 ------HCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTP-NYV 176 + K HRDL N+L+ N K++DFGLS + V + +T P ++ Sbjct: 151 VARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSR--GQEVYVKKTMGRLPVRWM 208 Query: 177 APEVLSGQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKI 222 A E L+ Y + +D+WS GV+L+ I++ G P+ LY K+ Sbjct: 209 AIESLNYSVYT-TNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKL 254 >2JD5-A nrPDB Length = 373 Score = 64.3 bits (155), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 62/229 (27%), Positives = 107/229 (46%), Gaps = 39/229 (17%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIK----------- 57 +Y + R +G G F+ V A++ +VA+KI+ + D+IK Sbjct: 19 ARYILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVRGDKVYTEAAEDEIKLLQRVNDADNT 78 Query: 58 REIS-----IMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGE----LFDRIVHKGRLEE 108 +E S I+K++ H N P+ +++V+ F GE L + H+G + Sbjct: 79 KEDSMGANHILKLLDHFN-------HKGPNGVHVVMVFEVLGENLLALIKKYEHRG-IPL 130 Query: 109 SESRKYFQQLVDAVAHCHCK-GVYHRDLKPENLLL---DTNGNL---KVSDFGLSALPQE 161 ++ +QL+ + + H + G+ H D+KPEN+L+ D+ NL K++D G + E Sbjct: 131 IYVKQISKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNACWYDE 190 Query: 162 GVELLRTTCGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPF 210 + T Y +PEVL G + G ADIWS ++F ++ G F Sbjct: 191 HY---TNSIQTREYRSPEVLLGAPW-GCGADIWSTACLIFELITGDFLF 235 >3BEA-A nrPDB Length = 333 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 56/221 (25%), Positives = 102/221 (46%), Gaps = 24/221 (10%) Query: 12 EVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIV----R 67 + G+T+G G F KV A G A+ +A + D+ + +S +KI+ + Sbjct: 49 QFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQ 108 Query: 68 HPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESR--------------K 113 H NIV L + ++ E+ G+L + + K R+ E++ Sbjct: 109 HENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKSRVLETDPAFAIANSTLSTRDLLH 168 Query: 114 YFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNL-KVSDFGLS-ALPQEGVELLRTTCG 171 + Q+ +A K HRD+ N+LL TNG++ K+ DFGL+ + + +++ Sbjct: 169 FSSQVAQGMAFLASKNCIHRDVAARNVLL-TNGHVAKIGDFGLARDIMNDSNYIVKGNAR 227 Query: 172 TP-NYVAPEVLSGQGYDGSAADIWSCGVILFVILA-GYLPF 210 P ++APE + Y +D+WS G++L+ I + G P+ Sbjct: 228 LPVKWMAPESIFDCVYT-VQSDVWSYGILLWEIFSLGLNPY 267 >2PVN-A nrPDB Length = 352 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 55/207 (26%), Positives = 101/207 (48%), Gaps = 20/207 (9%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 YEV R +G G +++V N + + IKI+ K + + + PN Sbjct: 54 YEVVRKVGRGKYSEVFEGINVNNNEKCIIKILKPVKKKK-----IKREIKILQNLCGGPN 108 Query: 71 IVRLYEVL-----ASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHC 125 IV+L +++ +PS ++ E+V + ++++ L + + R Y +L+ A+ +C Sbjct: 109 IVKLLDIVRDQHSKTPS---LIFEYVNNTDF--KVLYPT-LTDYDIRYYIYELLKALDYC 162 Query: 126 HCKGVYHRDLKPENLLLDTN-GNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSG- 183 H +G+ HRD+KP N+++D L++ D+GL+ G E + + PE+L Sbjct: 163 HSQGIMHRDVKPHNVMIDHELRKLRLIDWGLAEFYHPGKE-YNVRVASRYFKGPELLVDL 221 Query: 184 QGYDGSAADIWSCGVILFVILAGYLPF 210 Q YD S D+WS G + ++ PF Sbjct: 222 QDYDYS-LDMWSLGCMFAGMIFRKEPF 247 >4F9B-A nrPDB Length = 361 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 65/242 (26%), Positives = 100/242 (41%), Gaps = 41/242 (16%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR-HP 69 +++ IGEGTF+ V A KI K I + + +I E+ + + Sbjct: 23 FKIEDKIGEGTFSSVYLA-TAQLQVGPEEKIALKHLIPTSHPI-RIAAELQCLTVAGGQD 80 Query: 70 NIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKG 129 N++ + + I + ++ D + L E R+Y L A+ H G Sbjct: 81 NVMGVKYCFRKNDHVVIAMPYLEHESFLDIL---NSLSFQEVREYMLNLFKALKRIHQFG 137 Query: 130 VYHRDLKPENLLLDTNGNLK---VSDFGLSALPQEG-VELLR----------------TT 169 + HRD+KP N L N LK + DFGL+ + +ELL+ + Sbjct: 138 IVHRDVKPSNFLY--NRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNKCSI 195 Query: 170 C-----------GTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPF--SETDLP 216 C GTP + APEVL+ +A D+WS GVI +L+G PF + DL Sbjct: 196 CLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDDLT 255 Query: 217 GL 218 L Sbjct: 256 AL 257 >6GQK-A nrPDB Length = 328 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 66/276 (23%), Positives = 118/276 (42%), Gaps = 32/276 (11%) Query: 14 GRTIGEGTFAKVKFAR-----NTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIV-R 67 G+T+G G F KV A +D VA+K++ S R + + E+ ++ + Sbjct: 46 GKTLGAGAFGKVVEATAQGLIKSDAAMTVAVKMLKPSAHSTER--EALMSELKVLSYLGN 103 Query: 68 HPNIVRLYEVLASPSKIYIVLEFVTGGELFDRI----------------VHKGRLEESES 111 H NIV L ++ E+ G+L + + ++K L Sbjct: 104 HENIVNLLGACTHGGPTLVITEYCCYGDLLNFLRRKRDEFVPYKVAPEDLYKDFLTLEHL 163 Query: 112 RKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNL-KVSDFGLS-ALPQEGVELLRTT 169 + Q+ +A K HRDL N+LL T+GN+ K+ DFGL+ + + + + Sbjct: 164 LSFSYQVAKGMAFLASKNCIHRDLAARNILL-THGNITKICDFGLARDIKNDSNYVDKGN 222 Query: 170 CGTP-NYVAPEVLSGQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAAEF 227 P ++APE + Y +D+WS G+ L+ + + G P+ + + K+ F Sbjct: 223 ARLPVKWMAPESIFNSVYTFE-SDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGF 281 Query: 228 --SCPPWFSAEVKFLIHRILDPNPKTRIQIQGIKKD 261 S P + AE+ ++ D +P R + I +D Sbjct: 282 RMSSPEYAPAEMYDIMKTCWDADPDKRPTFKQIVQD 317 >3GQL-A nrPDB Length = 326 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 61/235 (25%), Positives = 106/235 (45%), Gaps = 30/235 (12%) Query: 13 VGRTIGEGTFAKVKFARNTDTGDN-------VAIKIMAKSTILKNRMVDQIKREISIMKI 65 +G+ +GEG F +V A + VA+K M KS + + D I E+ +MK+ Sbjct: 32 LGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVK-MLKSDATEKDLSDLIS-EMEMMKM 89 Query: 66 V-RHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHK------------GRLEESESR 112 + +H NI+ L +Y+++E+ + G L + + + EE S Sbjct: 90 IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSS 149 Query: 113 KYF----QQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRT 168 K Q+ + + K HRDL N+L+ + +K++DFGL+ +T Sbjct: 150 KDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKT 209 Query: 169 TCG--TPNYVAPEVLSGQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYR 220 T G ++APE L + Y +D+WS GV+L+ I G P+ + L++ Sbjct: 210 TNGRLPVKWMAPEALFDRIY-THQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFK 263 >3TT0-A nrPDB Length = 382 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 61/235 (25%), Positives = 106/235 (45%), Gaps = 30/235 (12%) Query: 13 VGRTIGEGTFAKVKFARNTDTGDN-------VAIKIMAKSTILKNRMVDQIKREISIMKI 65 +G+ +GEG F +V A + VA+K M KS + + D I E+ +MK+ Sbjct: 73 LGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVK-MLKSDATEKDLSDLIS-EMEMMKM 130 Query: 66 V-RHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHK------------GRLEESESR 112 + +H NI+ L +Y+++E+ + G L + + + EE S Sbjct: 131 IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYSYNPSHNPEEQLSS 190 Query: 113 KYF----QQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRT 168 K Q+ + + K HRDL N+L+ + +K++DFGL+ +T Sbjct: 191 KDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKT 250 Query: 169 TCG--TPNYVAPEVLSGQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYR 220 T G ++APE L + Y +D+WS GV+L+ I G P+ + L++ Sbjct: 251 TNGRLPVKWMAPEALFDRIYT-HQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFK 304 >2WO6-A nrPDB Length = 382 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 74/267 (27%), Positives = 119/267 (44%), Gaps = 34/267 (12%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 +YE+ IG+G+F +V A + + VAIKI+ K ++Q + E+ +++++ Sbjct: 55 RYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKN----KKAFLNQAQIEVRLLELMNKH 110 Query: 70 N------IVRLYEVLASPSKIYIVLEFVTGGELFD--RIVHKGRLEESESRKYFQQLVDA 121 + IV L + + +V E ++ L+D R + + + +RK+ QQ+ A Sbjct: 111 DTEMKYYIVHLKRHFMFRNHLCLVFEMLSYN-LYDLLRNTNFRGVSLNLTRKFAQQMCTA 169 Query: 122 VAHCHCK--GVYHRDLKPENLLL--DTNGNLKVSDFGLSA-LPQEGVELLRTTCGTPNYV 176 + + H DLKPEN+LL +K+ DFG S L Q + +++ Y Sbjct: 170 LLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRF----YR 225 Query: 177 APEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAE 236 +PEVL G YD A D+WS G IL + G FS + KI PP Sbjct: 226 SPEVLLGMPYD-LAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKI-VEVLGIPP----- 278 Query: 237 VKFLIHRILDPNPKTRIQIQGIKKDPW 263 ILD PK R + + W Sbjct: 279 -----AHILDQAPKARKFFEKLPDGTW 300 >4K33-A nrPDB Length = 325 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 57/220 (25%), Positives = 98/220 (44%), Gaps = 25/220 (11%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTG-DNVAIKIMAKSTILKNRMVDQ----IKREISIM 63 + +G+ +GEG F +V A D A + +LK+ D+ + E+ +M Sbjct: 36 ARLTLGKPLGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMM 95 Query: 64 KIV-RHPNIVRLYEVLASPSKIYIVLEFVTGGEL--FDRIVHKGRLEES-------ESRK 113 K++ +H NI+ L +Y+++E+ G L F R L+ S E + Sbjct: 96 KMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTSKPPEEQL 155 Query: 114 YFQQLVD-------AVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELL 166 F+ LV + + + HRDL N+L+ + +K++DFGL+ Sbjct: 156 TFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYK 215 Query: 167 RTTCG--TPNYVAPEVLSGQGYDGSAADIWSCGVILFVIL 204 TT G ++APE L + Y +D+WS GV+L+ I Sbjct: 216 ETTNGRLPVKWMAPEALFDRVY-THQSDVWSFGVLLWEIF 254 >2OGV-A nrPDB Length = 317 Score = 62.8 bits (151), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 58/217 (26%), Positives = 102/217 (47%), Gaps = 20/217 (9%) Query: 12 EVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIV----R 67 + G+T+G G F KV A G A+ +A + D+ + +S +KI+ + Sbjct: 41 QFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQ 100 Query: 68 HPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHK---------GR-LEESESRKYFQQ 117 H NIV L + ++ E+ G+L + + K GR LE + + Q Sbjct: 101 HENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEADLDKEDGRPLELRDLLHFSSQ 160 Query: 118 LVDAVAHCHCKGVYHRDLKPENLLLDTNGNL-KVSDFGLS-ALPQEGVELLRTTCGTP-N 174 + +A K HRD+ N+LL TNG++ K+ DFGL+ + + +++ P Sbjct: 161 VAQGMAFLASKNCIHRDVAARNVLL-TNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVK 219 Query: 175 YVAPEVLSGQGYDGSAADIWSCGVILFVILA-GYLPF 210 ++APE + Y +D+WS G++L+ I + G P+ Sbjct: 220 WMAPESIFDCVYT-VQSDVWSYGILLWEIFSLGLNPY 255 >5X02-A nrPDB Length = 347 Score = 62.8 bits (151), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 64/265 (24%), Positives = 113/265 (42%), Gaps = 36/265 (13%) Query: 12 EVGRTIGEGTFAKVKFA-----RNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIM-KI 65 E G+ +G G F KV A T VA+K++ + R + + E+ +M ++ Sbjct: 51 EFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSER--EALMSELKMMTQL 108 Query: 66 VRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHK--------------GRLEESES 111 H NIV L IY++ E+ G+L + + K RLEE E Sbjct: 109 GSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRLEEEED 168 Query: 112 RK---------YFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLS-ALPQE 161 + Q+ + K HRDL N+L+ +K+ DFGL+ + + Sbjct: 169 LNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSD 228 Query: 162 GVELLRTTCGTP-NYVAPEVLSGQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLY 219 ++R P ++APE L +G +D+WS G++L+ I + G P+ + + Sbjct: 229 SNYVVRGNARLPVKWMAPESLF-EGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANF 287 Query: 220 RKINAAEFSC-PPWFSAEVKFLIHR 243 K+ F P+++ E ++I + Sbjct: 288 YKLIQNGFKMDQPFYATEEIYIIMQ 312 >5EG3-A nrPDB Length = 334 Score = 62.8 bits (151), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 57/239 (23%), Positives = 107/239 (44%), Gaps = 32/239 (13%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDN-------VAIKIMAKSTILKNRMVDQIKREISI 62 K +G+ +GEG F +V A + VA+K++ K+ + + E+ + Sbjct: 36 KLTLGKPLGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKD--LSDLVSEMEM 93 Query: 63 MKIV-RHPNIVRLYEVLASPSKIYIVLEFVTGGEL--FDRIVHKGRLEES-------ESR 112 MK++ +H NI+ L +Y+++ + + G L + R +E S E + Sbjct: 94 MKMIGKHKNIINLLGACTQDGPLYVIVAYASKGNLREYLRARRPPGMELSPDINRVPEEQ 153 Query: 113 KYFQQLVD-------AVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVEL 165 F+ LV + + + HRDL N+L+ N +K++DFGL A ++ Sbjct: 154 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGL-ARDINNIDF 212 Query: 166 LRTTCG---TPNYVAPEVLSGQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYR 220 + T ++APE L + Y +D+WS GV+++ I G P+ + L++ Sbjct: 213 FKETTNGRLPVKWMAPEALFDRVY-THQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFK 270 >3PG1-A nrPDB Length = 362 Score = 62.8 bits (151), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 85/347 (24%), Positives = 143/347 (41%), Gaps = 61/347 (17%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVD---------QIKREIS 61 Y V R I G++ V +++ G VAIK +T+ R V+ ++ REI Sbjct: 24 YTVQRFISSGSYGAVCAGVDSE-GIPVAIK-RVFNTVSDGRTVNILSDSFLCKRVLREIR 81 Query: 62 IMKIVRHPNIVRLYEVLA-----SPSKIYIVLEFVTGGELFDRIVHKGRLEESESR-KYF 115 ++ HPNI+ L ++ + K+Y+V E + +++H R+ S +YF Sbjct: 82 LLNHFHHPNILGLRDIFVHFEEPAMHKLYLVTELMRTD--LAQVIHDQRIVISPQHIQYF 139 Query: 116 QQLVDAVAHC-HCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPN 174 + H H GV HRDL P N+LL N ++ + DF L+ ++ + +T T Sbjct: 140 MYHILLGLHVLHEAGVVHRDLHPGNILLADNNDITICDFNLAR--EDTADANKTHYVTHR 197 Query: 175 -YVAPE-VLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKI---------- 222 Y APE V+ +G+ D+WS G ++ + F + KI Sbjct: 198 WYRAPELVMQFKGF-TKLVDMWSAGCVMAEMFNRKALFRGSTFYNQLNKIVEVVGTPKIE 256 Query: 223 NAAEFSCP----------------------PWFSAEVKFLIHRILDPNPKTRIQIQGIKK 260 + FS P P LI ++L+ NP+ RI + + Sbjct: 257 DVVMFSSPSARDYLRNSLSNVPARAWTAVVPTADPVALDLIAKMLEFNPQRRISTEQALR 316 Query: 261 DPWFRLNYVPIRARE--EEEVNLDD-IRAVFDGIEGSYVAENVERND 304 P+F + P+ E E + D+ + V+D + + AE ND Sbjct: 317 HPYFESLFDPLDLTEGLSERFHFDESVTDVYD-MHKIFTAEVERFND 362 >5MJB-A nrPDB Length = 305 Score = 62.8 bits (151), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 64/236 (27%), Positives = 102/236 (43%), Gaps = 26/236 (11%) Query: 12 EVGRTIGEGTFAKVKFARNTDTGDN---VAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 ++ IG G F +V R G VAIK + K R E SIM H Sbjct: 29 KIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRR--DFLSEASIMGQFDH 86 Query: 69 PNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHK--GRLEESESRKYFQQLVDAVAHCH 126 NI+RL V+ + I+ EF+ L D + + G+ + + + + + Sbjct: 87 RNIIRLEGVVTKSRPVMIITEFMENCAL-DSFLRQNDGQFTVIQLVGMLRGIAAGMKYLS 145 Query: 127 CKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPN-----YVAPEVL 181 HRDL N+L+++N KVSDFGLS Q+ T + APE + Sbjct: 146 EMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAI 205 Query: 182 SGQGYDGSAADIWSCGVILFVILA----GYLPFSETDLPGLYRKINAAE--FSCPP 231 + + + SA+D+WS G++++ +++ Y S D+ INA E + PP Sbjct: 206 AYRKFT-SASDVWSYGIVMWEVMSFGERPYWDMSNQDV------INAIEQDYRLPP 254 >4XUF-A nrPDB Length = 297 Score = 62.8 bits (151), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 64/265 (24%), Positives = 113/265 (42%), Gaps = 36/265 (13%) Query: 12 EVGRTIGEGTFAKVKFA-----RNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIM-KI 65 E G+ +G G F KV A T VA+K++ + R + + E+ +M ++ Sbjct: 12 EFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSER--EALMSELKMMTQL 69 Query: 66 VRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHK--------------GRLEESES 111 H NIV L IY++ E+ G+L + + K RLEE E Sbjct: 70 GSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRLEEEED 129 Query: 112 RK---------YFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLS-ALPQE 161 + Q+ + K HRDL N+L+ +K+ DFGL+ + + Sbjct: 130 LNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSD 189 Query: 162 GVELLRTTCGTP-NYVAPEVLSGQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLY 219 ++R P ++APE L +G +D+WS G++L+ I + G P+ + + Sbjct: 190 SNYVVRGNARLPVKWMAPESLF-EGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANF 248 Query: 220 RKINAAEFSC-PPWFSAEVKFLIHR 243 K+ F P+++ E ++I + Sbjct: 249 YKLIQNGFKMDQPFYATEEIYIIMQ 273 >5A46-A nrPDB Length = 386 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 59/219 (26%), Positives = 101/219 (46%), Gaps = 29/219 (13%) Query: 13 VGRTIGEGTFAKVKFAR----NTDTGD---NVAIKIMAKSTILKNRMVDQIKREISIMKI 65 +G+ +GEG F +V A + D + VA+K M KS + + D I E+ +MK+ Sbjct: 44 LGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVK-MLKSDATEKDLSDLIS-EMEMMKM 101 Query: 66 V-RHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHK------------GRLEESESR 112 + +H NI+ L +Y+++E+ + G L + + + EE S Sbjct: 102 IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSS 161 Query: 113 KYF----QQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRT 168 K Q+ + + K HRDL N+L+ + +K++DFGL+ +T Sbjct: 162 KDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKT 221 Query: 169 TCG--TPNYVAPEVLSGQGYDGSAADIWSCGVILFVILA 205 T G ++APE L + Y +D+WS GV+L+ I Sbjct: 222 TNGRLPVKWMAPEALFDRIYT-HQSDVWSFGVLLWEIFT 259 >4M66-A nrPDB Length = 325 Score = 62.4 bits (150), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 58/209 (27%), Positives = 96/209 (45%), Gaps = 33/209 (15%) Query: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYE 76 +G+G F V A + +VA+KI+ +I E+ M +R+ N++ L Sbjct: 28 VGKGGFGVVFRAHHRTWNHDVAVKIVNSK---------KISWEVKAMVNLRNENVLLLLG 78 Query: 77 VLASPSKIYIVLEFVTGGELFDRIVHKGRL----EESESRKY------FQQLVDAVAHCH 126 V + +FV+G L R + G L + R + Q++V + + H Sbjct: 79 VTED-----LQWDFVSGQALVTRFMENGSLAGLLQPEAPRPWPLLCRLLQEVVLGMCYLH 133 Query: 127 C--KGVYHRDLKPENLLLDTNGNLKVSDFGLSALP------QEGVELLRTTCGTPNYVAP 178 + HRDLKP N+LLD + K++DFGLS R + GT Y+ P Sbjct: 134 SLDPPLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGSGSGSGSRDSGGTLAYLDP 193 Query: 179 EVLSGQGYDGS-AADIWSCGVILFVILAG 206 E+L S A+D++S G++++ +LAG Sbjct: 194 ELLFKVNLKASKASDVYSFGILVWAVLAG 222 >2PZI-A nrPDB Length = 681 Score = 61.6 bits (148), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 68/254 (26%), Positives = 117/254 (46%), Gaps = 31/254 (12%) Query: 9 GKYEVGRTIGEGTFAKVKFA--RNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIV 66 G+YEV I G + A RN + G V +K + S + + + +R+ + V Sbjct: 80 GQYEVKGCIAHGGLGWIYLALDRNVN-GRPVVLKGLVHSGDAEAQAMAMAERQF--LAEV 136 Query: 67 RHPNIVRLYEVLASPSKI-----YIVLEFVTGGELFDRIVHKG-RLEESESRKYFQQLVD 120 HP+IV+++ + + YIV+E+V GG+ R KG +L +E+ Y +++ Sbjct: 137 VHPSIVQIFNFVEHTDRHGDPVGYIVMEYV-GGQSLKR--SKGQKLPVAEAIAYLLEILP 193 Query: 121 AVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEV 180 A+++ H G+ + DLKPEN++L T LK+ D G + + GTP + APE+ Sbjct: 194 ALSYLHSIGLVYNDLKPENIML-TEEQLKLIDLGAVSR----INSFGYLYGTPGFQAPEI 248 Query: 181 LSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKF- 239 + + A DI++ G L + DLP + P + Sbjct: 249 V--RTGPTVATDIYTVGRTLAAL--------TLDLPTRNGRYVDGLPEDDPVLKTYDSYG 298 Query: 240 -LIHRILDPNPKTR 252 L+ R +DP+P+ R Sbjct: 299 RLLRRAIDPDPRQR 312 >3Q4U-A nrPDB Length = 301 Score = 61.2 bits (147), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 53/208 (25%), Positives = 93/208 (44%), Gaps = 32/208 (15%) Query: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIV--RHPNIVRL 74 +G+G + +V R + G+NVA+KI + +R RE + V RH NI+ Sbjct: 16 VGKGRYGEV--WRGSWQGENVAVKIFS------SRDEKSWFRETELYNTVMLRHENILGF 67 Query: 75 ----YEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCK-- 128 S ++++++ + G L+D + L+ + + +AH H + Sbjct: 68 IASDMTSRHSSTQLWLITHYHEMGSLYDYL-QLTTLDTVSCLRIVLSIASGLAHLHIEIF 126 Query: 129 ------GVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELL----RTTCGTPNYVAP 178 + HRDLK +N+L+ NG ++D GL+ + + L GT Y+AP Sbjct: 127 GTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAP 186 Query: 179 EVLSG----QGYDG-SAADIWSCGVILF 201 EVL +D DIW+ G++L+ Sbjct: 187 EVLDETIQVDCFDSYKRVDIWAFGLVLW 214 >5UNP-A nrPDB Length = 369 Score = 61.2 bits (147), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 62/233 (26%), Positives = 97/233 (41%), Gaps = 37/233 (15%) Query: 10 KYEVGRTIGEGTFAKV-KFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 +YE+ T+GEGTF +V + + G VA+KI+ K + + EI++++ + Sbjct: 35 RYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYK----EAARLEINVLEKINE 90 Query: 69 PN------IVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEE--SESRKYFQQLVD 120 + V++++ + I E + G FD + L + R QL Sbjct: 91 KDPDNKNLCVQMFDWFDYHGHMCISFELL-GLSTFDFLKDNNYLPYPIHQVRHMAFQLCQ 149 Query: 121 AVAHCHCKGVYHRDLKPENLLL-----DTNGNL--------------KVSDFGLSALPQE 161 AV H + H DLKPEN+L + NL +V DFG + E Sbjct: 150 AVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHE 209 Query: 162 GVELLRTTCGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETD 214 T T +Y APEV+ G+ D+WS G I+F G+ F D Sbjct: 210 HHS---TIVSTRHYRAPEVILELGW-SQPCDVWSIGCIIFEYYVGFTLFQTHD 258 >6EII-A nrPDB Length = 352 Score = 60.8 bits (146), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 43/146 (29%), Positives = 75/146 (51%), Gaps = 9/146 (6%) Query: 69 PNIVRLYEVLASP--SKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCH 126 PNI+ L +++ P +V E V + F ++ L + + R Y +++ A+ +CH Sbjct: 115 PNIITLADIVKDPVSRTPALVFEHVNNTD-FKQLYQT--LTDYDIRFYMYEILKALDYCH 171 Query: 127 CKGVYHRDLKPENLLLD-TNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVL-SGQ 184 G+ HRD+KP N+++D + L++ D+GL+ G E + + PE+L Q Sbjct: 172 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE-YNVRVASRYFKGPELLVDYQ 230 Query: 185 GYDGSAADIWSCGVILFVILAGYLPF 210 YD S D+WS G +L ++ PF Sbjct: 231 MYDYS-LDMWSLGCMLASMIFRKEPF 255 >5FM2-A nrPDB Length = 355 Score = 60.8 bits (146), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 54/222 (24%), Positives = 99/222 (44%), Gaps = 30/222 (13%) Query: 13 VGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIK---REISIMKIVRHP 69 +G+T+GEG F KV A +A + +N +++ E +++K V HP Sbjct: 68 LGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHP 127 Query: 70 NIVRLYEVLASPSKIYIVLEFVTGGELF-----DRIVHKG-----------RLEESESR- 112 ++++LY + + +++E+ G L R V G L+ + R Sbjct: 128 HVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERA 187 Query: 113 -------KYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLS-ALPQEGVE 164 + Q+ + + + HRDL N+L+ +K+SDFGLS + +E Sbjct: 188 LTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSY 247 Query: 165 LLRTTCGTP-NYVAPEVLSGQGYDGSAADIWSCGVILFVILA 205 + R+ P ++A E L Y + +D+WS GV+L+ I+ Sbjct: 248 VKRSQGRIPVKWMAIESLFDHIYT-TQSDVWSFGVLLWEIVT 288 >4Y12-A nrPDB Length = 375 Score = 60.8 bits (146), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 68/255 (26%), Positives = 117/255 (45%), Gaps = 31/255 (12%) Query: 8 VGKYEVGRTIGEGTFAKVKFA--RNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKI 65 G+YEV I G + A RN + G V +K + S + + + +R+ + Sbjct: 118 AGQYEVKGCIAHGGLGWIYLALDRNVN-GRPVVLKGLVHSGDAEAQAMAMAERQF--LAE 174 Query: 66 VRHPNIVRLYEVLASPSKI-----YIVLEFVTGGELFDRIVHKG-RLEESESRKYFQQLV 119 V HP+IV+++ + + YIV+E+V GG+ R KG +L +E+ Y +++ Sbjct: 175 VVHPSIVQIFNFVEHTDRHGDPVGYIVMEYV-GGQSLKR--SKGQKLPVAEAIAYLLEIL 231 Query: 120 DAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPE 179 A+++ H G+ + DLKPEN++L T LK+ D G + + GTP + APE Sbjct: 232 PALSYLHSIGLVYNDLKPENIML-TEEQLKLIDLGAVSR----INSFGYLYGTPGFQAPE 286 Query: 180 VLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKF 239 ++ + A DI++ G L + DLP + P + Sbjct: 287 IV--RTGPTVATDIYTVGRTLAAL--------TLDLPTRNGRYVDGLPEDDPVLKTYDSY 336 Query: 240 --LIHRILDPNPKTR 252 L+ R +DP+P+ R Sbjct: 337 GRLLRRAIDPDPRQR 351 >4R7H-A nrPDB Length = 343 Score = 60.8 bits (146), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 59/230 (25%), Positives = 103/230 (44%), Gaps = 33/230 (14%) Query: 12 EVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIV----R 67 + G+T+G G F KV A G A+ +A + D+ + +S +KI+ + Sbjct: 53 QFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQ 112 Query: 68 HPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHK----------------------GR 105 H NIV L + ++ E+ T G+L + + K GR Sbjct: 113 HENIVNLLGACTHGGPVLVITEYCTYGDLLNFLRRKAEAMLGPSLSPGQDPEGLDKEDGR 172 Query: 106 -LEESESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNL-KVSDFGLS-ALPQEG 162 LE + + Q+ +A K HRD+ N+LL TNG++ K+ DFGL+ + + Sbjct: 173 PLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLL-TNGHVAKIGDFGLARDIMNDS 231 Query: 163 VELLRTTCGTP-NYVAPEVLSGQGYDGSAADIWSCGVILFVILA-GYLPF 210 +++ P ++APE + Y +D+WS G++L+ I + G P+ Sbjct: 232 NYIVKGNARLPVKWMAPESIFDSVYT-VQSDVWSYGILLWEIFSLGLNPY 280 >3LMG-A nrPDB Length = 344 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 50/203 (24%), Positives = 97/203 (47%), Gaps = 8/203 (3%) Query: 15 RTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKN--RMVDQIKREISIMKIVRHPNIV 72 + +G G F V G+++ I + K K+ + + + + + H +IV Sbjct: 37 KVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIV 96 Query: 73 RLYEVLASPSKIYIVLEFVTGGELFDRI-VHKGRLEESESRKYFQQLVDAVAHCHCKGVY 131 RL L S + +V +++ G L D + H+G L + Q+ + + G+ Sbjct: 97 RLLG-LCPGSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEHGMV 155 Query: 132 HRDLKPENLLLDTNGNLKVSDFGLS-ALPQEGVELLRTTCGTP-NYVAPEVLSGQGYDGS 189 HR+L N+LL + ++V+DFG++ LP + +LL + TP ++A E + Y Sbjct: 156 HRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHFGKYT-H 214 Query: 190 AADIWSCGVILFVILA-GYLPFS 211 +D+WS GV ++ ++ G P++ Sbjct: 215 QSDVWSYGVTVWELMTFGAEPYA 237 >4XLV-A nrPDB Length = 328 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 55/208 (26%), Positives = 101/208 (48%), Gaps = 20/208 (9%) Query: 15 RTIGEGTFAKV--KFARNTDTGD---NVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 R +G+G+F V AR+ G+ VA+K + +S L+ R+ + E S+MK Sbjct: 45 RELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERI--EFLNEASVMKGFTCH 102 Query: 70 NIVRLYEVLASPSKIYIVLEFVTGGELFDRI--------VHKGRLEES--ESRKYFQQLV 119 ++VRL V++ +V+E + G+L + + GR + E + ++ Sbjct: 103 HVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIA 162 Query: 120 DAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCG--TPNYVA 177 D +A+ + K HRDL N ++ + +K+ DFG++ E + G ++A Sbjct: 163 DGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMA 222 Query: 178 PEVLSGQGYDGSAADIWSCGVILFVILA 205 PE L G +++D+WS GV+L+ I + Sbjct: 223 PESLK-DGVFTTSSDMWSFGVVLWEITS 249 >6HMD-A nrPDB Length = 365 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 44/145 (30%), Positives = 76/145 (52%), Gaps = 9/145 (6%) Query: 70 NIVRLYEVLASP-SKI-YIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHC 127 NI++L + + P SK +V E++ + F ++ L + + R Y +L+ A+ +CH Sbjct: 109 NIIKLIDTVKDPVSKTPALVFEYINNTD-FKQLYQI--LTDFDIRFYMYELLKALDYCHS 165 Query: 128 KGVYHRDLKPENLLLD-TNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVL-SGQG 185 KG+ HRD+KP N+++D L++ D+GL+ E + + PE+L Q Sbjct: 166 KGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQE-YNVRVASRYFKGPELLVDYQM 224 Query: 186 YDGSAADIWSCGVILFVILAGYLPF 210 YD S D+WS G +L ++ PF Sbjct: 225 YDYS-LDMWSLGCMLASMIFRREPF 248 >3BBT-B nrPDB Length = 328 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 53/199 (26%), Positives = 96/199 (48%), Gaps = 13/199 (6%) Query: 15 RTIGEGTFAKVKFARNTDTGDNV----AIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 + +G G F V G+ V AIKI+ ++T K + + E IM + HP+ Sbjct: 21 KVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANV--EFMDEALIMASMDHPH 78 Query: 71 IVRLYEVLASPSKIYIVLEFVTGGELFDRI-VHKGRLEESESRKYFQQLVDAVAHCHCKG 129 +VRL V SP+ I +V + + G L + + HK + + Q+ + + + Sbjct: 79 LVRLLGVCLSPT-IQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERR 137 Query: 130 VYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTP---NYVAPEVLSGQGY 186 + HRDL N+L+ + ++K++DFGL+ L EG E G ++A E + + + Sbjct: 138 LVHRDLAARNVLVKSPNHVKITDFGLARL-LEGDEKEYNADGGKMPIKWMALECIHYRKF 196 Query: 187 DGSAADIWSCGVILFVILA 205 +D+WS GV ++ ++ Sbjct: 197 T-HQSDVWSYGVTIWELMT 214 >4MD7-E nrPDB Length = 391 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 43/146 (29%), Positives = 75/146 (51%), Gaps = 9/146 (6%) Query: 69 PNIVRLYEVLASP--SKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCH 126 PNI+ L +++ P +V E V + F ++ L + + R Y +++ A+ +CH Sbjct: 92 PNIITLADIVKDPVSRTPALVFEHVNNTD-FKQLYQT--LTDYDIRFYMYEILKALDYCH 148 Query: 127 CKGVYHRDLKPENLLLD-TNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVL-SGQ 184 G+ HRD+KP N+++D + L++ D+GL+ G E + + PE+L Q Sbjct: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE-YNVRVASRYFKGPELLVDYQ 207 Query: 185 GYDGSAADIWSCGVILFVILAGYLPF 210 YD S D+WS G +L ++ PF Sbjct: 208 MYDYS-LDMWSLGCMLASMIFRKEPF 232 >3MY0-A nrPDB Length = 305 Score = 59.7 bits (143), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 55/212 (25%), Positives = 95/212 (44%), Gaps = 36/212 (16%) Query: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIV--RHPNIVRL 74 +G+G + +V R G++VA+KI + +R RE I V RH NI+ Sbjct: 16 VGKGRYGEV--WRGLWHGESVAVKIFS------SRDEQSWFRETEIYNTVLLRHDNILGF 67 Query: 75 ----YEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCK-- 128 S ++++++ + G L+D + + LE + + +AH H + Sbjct: 68 IASDMTSRNSSTQLWLITHYHEHGSLYD-FLQRQTLEPHLALRLAVSAACGLAHLHVEIF 126 Query: 129 ------GVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELL----RTTCGTPNYVAP 178 + HRD K N+L+ +N ++D GL+ + +G + L GT Y+AP Sbjct: 127 GTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAP 186 Query: 179 EVLSGQ-------GYDGSAADIWSCGVILFVI 203 EVL Q Y + DIW+ G++L+ I Sbjct: 187 EVLDEQIRTDCFESYKWT--DIWAFGLVLWEI 216 >6J5U-C nrPDB Length = 426 Score = 59.7 bits (143), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 46/158 (29%), Positives = 77/158 (48%), Gaps = 15/158 (9%) Query: 59 EISIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQL 118 E++ + + HPN+V L A +V EF+ G L + + +G ++ + ++ Sbjct: 140 EVNYLGQLSHPNLVLLVGYCAEGENRLLVYEFMPKGSLENHLFRRG----AQPLTWAIRM 195 Query: 119 VDAVA--------HCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTT- 169 AV H V +RD K N+LLD + N K+SDFGL+ G +T Sbjct: 196 KVAVGAAKGLTFLHEAKSQVIYRDFKAANILLDADFNAKLSDFGLAKAGPTGDNTHVSTK 255 Query: 170 -CGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAG 206 GT Y APE ++ G + +D++S GV+L +++G Sbjct: 256 VIGTHGYAAPEYVA-TGRLTAKSDVYSFGVVLLELISG 292 >5M07-A nrPDB Length = 276 Score = 59.7 bits (143), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 43/209 (20%), Positives = 95/209 (45%), Gaps = 21/209 (10%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 Y V R +G +V ++ A+K+++ + + + +RE + + HP+ Sbjct: 32 YTVVRMLGASAMGEVYLVQHPGFPGWQALKVLSPAMAADDEFRRRFQRETEVAARLFHPH 91 Query: 71 IVRLYEVLASPSKIYIVLEFVTGGELFDRIVHK--GRLEESESRKYFQQLVDAVAHCHCK 128 I+ +++ +++I +++V G + + + L E + A+ + H + Sbjct: 92 ILEVHDRGEFDGQLWIAMDYVDGIDATQHMADRFPAVLPVGEVLAIVTAVAGALDYAHQR 151 Query: 129 GVYHRDLKPENLLLDTN--GNLKV--SDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQ 184 G+ HRD+ P N++L + G+ ++ +DFG+++ P+Y APE+ +G Sbjct: 152 GLLHRDVNPANVVLTSQSAGDQRILLADFGIAS--------------QPSYPAPELSAGA 197 Query: 185 GYDGSAADIWSCGVILFVILAGYLPFSET 213 DG AD ++ + + AG P + Sbjct: 198 DVDGR-ADQYALALTAIHLFAGAPPVDRS 225 >3V5Q-A nrPDB Length = 297 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 54/214 (25%), Positives = 94/214 (43%), Gaps = 27/214 (12%) Query: 15 RTIGEGTFAKVKFARN---TDTGDN--VAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 R +GEG F KV A + T D VA+K + T+ + +RE ++ ++H Sbjct: 21 RELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARK---DFQREAELLTNLQHE 77 Query: 70 NIVRLYEVLASPSKIYIVLEFVTGGELF--------DRIV--------HKGRLEESESRK 113 +IV+ Y V + +V E++ G+L D ++ KG L S+ Sbjct: 78 HIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLH 137 Query: 114 YFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLS--ALPQEGVELLRTTCG 171 Q+ + + + HRDL N L+ N +K+ DFG+S + + T Sbjct: 138 IASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTML 197 Query: 172 TPNYVAPEVLSGQGYDGSAADIWSCGVILFVILA 205 ++ PE + + + + +D+WS GVIL+ I Sbjct: 198 PIRWMPPESIMYRKFT-TESDVWSFGVILWEIFT 230 >3KRL-A nrPDB Length = 335 Score = 58.5 bits (140), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 53/217 (24%), Positives = 97/217 (44%), Gaps = 25/217 (11%) Query: 12 EVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIV----R 67 + G+T+G G F KV A G A+ +A + D+ + +S +KI+ + Sbjct: 49 QFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQ 108 Query: 68 HPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHK----------------GRLEESES 111 H NIV L + ++ E+ G+L + + K +L + Sbjct: 109 HENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKRPPGLEYSYNPSHNPEEQLSSRDL 168 Query: 112 RKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNL-KVSDFGLS-ALPQEGVELLRTT 169 + Q+ +A K HRD+ N+LL TNG++ K+ DFGL+ + + +++ Sbjct: 169 LHFSSQVAQGMAFLASKNCIHRDVAARNVLL-TNGHVAKIGDFGLARDIMNDSNYIVKGN 227 Query: 170 CGTP-NYVAPEVLSGQGYDGSAADIWSCGVILFVILA 205 P ++APE + Y +D+WS G++L+ I + Sbjct: 228 ARLPVKWMAPESIFDCVYT-VQSDVWSYGILLWEIFS 263 >5AR8-A nrPDB Length = 326 Score = 58.5 bits (140), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 57/214 (26%), Positives = 91/214 (42%), Gaps = 12/214 (5%) Query: 15 RTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRL 74 R + G V AR+ D VA+K + T L + + RE I+ R I+ + Sbjct: 38 RYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPI 97 Query: 75 YEVLASPSKIYIVLEFVTGG---ELFDRIVHKGRLEESESRKYFQQLVDAVAHCH--CKG 129 + P + IV E++ G EL R + + ++ V + H Sbjct: 98 LGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPP 157 Query: 130 VYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPN-----YVAPEVLS-G 183 + H DLK +N+LLD ++K++DFGLS + R++ P Y+ PE G Sbjct: 158 LLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPG 217 Query: 184 QGYDGS-AADIWSCGVILFVILAGYLPFSETDLP 216 Q S DI+S VI + +L+ PF + P Sbjct: 218 QKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNP 251 >3ZZW-A nrPDB Length = 289 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 57/248 (22%), Positives = 102/248 (41%), Gaps = 32/248 (12%) Query: 17 IGEGTFAKVKFAR-----NTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNI 71 +GE F KV + VAIK + + + ++ + E + ++HPN+ Sbjct: 17 LGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKA--EGPLREEFRHEAMLRARLQHPNV 74 Query: 72 VRLYEVLASPSKIYIVLEFVTGGELFDRIVH----------------KGRLEESESRKYF 115 V L V+ + ++ + + G+L + +V K LE + Sbjct: 75 VCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHLV 134 Query: 116 QQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGL--SALPQEGVELLRTTCGTP 173 Q+ + + V H+DL N+L+ N+K+SD GL + +LL + Sbjct: 135 AQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSLLPI 194 Query: 174 NYVAPEVLSGQGYDGSAADIWSCGVILFVI----LAGYLPFSETDLPGLY--RKINAAEF 227 ++APE + G +DIWS GV+L+ + L Y +S D+ + R++ Sbjct: 195 RWMAPEAIM-YGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCPD 253 Query: 228 SCPPWFSA 235 CP W A Sbjct: 254 DCPAWVYA 261 >4AT3-A nrPDB Length = 299 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 62/268 (23%), Positives = 107/268 (39%), Gaps = 30/268 (11%) Query: 15 RTIGEGTFAKVKFARNTDTG---DNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNI 71 R +GEG F KV A + D + + + N D RE ++ ++H +I Sbjct: 19 RELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKD-FHREAELLTNLQHEHI 77 Query: 72 VRLYEVLASPSKIYIVLEFVTGGELFDRIVHKG-------------RLEESESRKYFQQL 118 V+ Y V + +V E++ G+L + G L +S+ QQ+ Sbjct: 78 VKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQI 137 Query: 119 VDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLS--ALPQEGVELLRTTCGTPNYV 176 + + + HRDL N L+ N +K+ DFG+S + + T ++ Sbjct: 138 AAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWM 197 Query: 177 APEVLSGQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAAEF-----SCP 230 PE + + + + +D+WS GV+L+ I G P+ + + I +CP Sbjct: 198 PPESIMYRKFT-TESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCP 256 Query: 231 PWFSAEVKFLIHRILDPNPKTRIQIQGI 258 EV L+ P R I+GI Sbjct: 257 ----QEVYELMLGCWQREPHMRKNIKGI 280 >5WNL-A nrPDB Length = 342 Score = 56.2 bits (134), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 49/211 (23%), Positives = 99/211 (46%), Gaps = 10/211 (4%) Query: 8 VGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR 67 G++ +G G F +V R+ +AIK + S + +R ++ E M++ + Sbjct: 19 AGEFAGWEKVGSGGFGQVYKVRHVHWKTWLAIKC-SPSLHVDDRERMELLEEAKKMEMAK 77 Query: 68 HPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDA-VAHCH 126 I+ +Y + P + +V+E++ G L + + + R + V HC Sbjct: 78 FRYILPVYGICQEP--VGLVMEYMETGSLEKLLASEPLPWDLRFRIVHETAVGMNFLHCM 135 Query: 127 CKGVYHRDLKPENLLLDTNGNLKVSDFGLS---ALPQEGVELLRTTCGTPNYVAPEVLSG 183 + H +LKP N+LLD + ++K+SDFGL+ + + GT Y+ PE + Sbjct: 136 SPPLLHLNLKPANILLDAHYHVKISDFGLAKCNGMSHSHDLSMDGLFGTIAYLPPERIRE 195 Query: 184 QG--YDGSAADIWSCGVILFVILAGYLPFSE 212 + +D + D++S ++++ +L PF++ Sbjct: 196 KSRLFD-TKHDVYSFAIVIWGVLTQKKPFAD 225 >3I81-A nrPDB Length = 315 Score = 56.2 bits (134), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 51/211 (24%), Positives = 96/211 (45%), Gaps = 20/211 (9%) Query: 10 KYEVGRTIGEGTFAKV-----KFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMK 64 K + R +G+G+F V K + VAIK + ++ ++ R+ + E S+MK Sbjct: 19 KITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERI--EFLNEASVMK 76 Query: 65 IVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFD-------RIVHKGRLEESESRKYFQ- 116 ++VRL V++ +++E +T G+L + + L K Q Sbjct: 77 EFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQM 136 Query: 117 --QLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCG--T 172 ++ D +A+ + HRDL N ++ + +K+ DFG++ E + G Sbjct: 137 AGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLP 196 Query: 173 PNYVAPEVLSGQGYDGSAADIWSCGVILFVI 203 +++PE L G + +D+WS GV+L+ I Sbjct: 197 VRWMSPESLK-DGVFTTYSDVWSFGVVLWEI 226 >4JRN-A nrPDB Length = 372 Score = 55.8 bits (133), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 66/279 (23%), Positives = 111/279 (39%), Gaps = 52/279 (18%) Query: 14 GRTIGEGTFAKVKFARNTDTGDNVAIKI-MAKSTILKNRMVD-----QIKREISIMKIVR 67 G +G G FA V A + +T + +A+K+ M++ M+D R S+ K + Sbjct: 73 GAPLGSGGFATVYEATDVETNEELAVKVFMSEKEPTDETMLDLQRESSCYRNFSLAKTAK 132 Query: 68 H---------PNIVRLYEVLASPSKIYIVLEFVT----------------GGELFDRIVH 102 P+ V + E P+ +V+ T ++ + Sbjct: 133 DAQESCRFMVPSDVVMLE--GQPASTEVVIGLTTRWVPNYFLLMMRAEADMSKVISWVFG 190 Query: 103 KGRLEESE----SRKYFQ-QLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSA 157 + +SE R Y Q + VA+ +G+ H D+KP N LL +G L + DFG Sbjct: 191 DASVNKSEFGLVVRMYLSSQAIKLVANVQAQGIVHTDIKPANFLLLKDGRLFLGDFGTYR 250 Query: 158 LPQEGVELLRTTCGTPNYVAPE---VLSGQGYDGSAADIWSCGVILFVILAGYLPFSETD 214 + + GTP Y PE +G Y D W G+ L+ I P T Sbjct: 251 INNS----VGRAIGTPGYEPPERPFQATGITYT-FPTDAWQLGITLYCIWCKERP---TP 302 Query: 215 LPGLYRKINAAEFSCPPWFSAEVKFLIHRILDPNPKTRI 253 G++ ++ A+ P V+ LI +L+ +P+ R+ Sbjct: 303 ADGIWDYLHFADCPSTPEL---VQDLIRSLLNRDPQKRM 338 >4L00-A nrPDB Length = 304 Score = 55.8 bits (133), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 71/271 (26%), Positives = 115/271 (42%), Gaps = 35/271 (12%) Query: 14 GRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISI--------MKI 65 G +G GT + D D+ K ++ +++D R+IS+ M+ Sbjct: 30 GEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVIL-KVLDPSHRDISLAFFEAASMMRQ 88 Query: 66 VRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGR--LEESESRKYFQQLVDAVA 123 V H +IV LY V + +V EFV GG L D +H+ L K +QL A++ Sbjct: 89 VSHKHIVYLYGVCVRDVENIMVEEFVEGGPL-DLFMHRKSDVLTTPWKFKVAKQLASALS 147 Query: 124 HCHCKGVYHRDLKPENLLLDTNG-------NLKVSDFGLSAL---PQEGVELLRTTCGTP 173 + K + H ++ +NLLL G +K+SD G+ QE +E + Sbjct: 148 YLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERI------- 200 Query: 174 NYVAPEVLSGQGYDGSAADIWSCGVILF-VILAGYLPFSETDLPGLYRKINAAEFSCPPW 232 ++APE + AAD WS G L+ + G +P + L K E C P Sbjct: 201 PWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDK---TLIEKERFYESRCRPV 257 Query: 233 FSA--EVKFLIHRILDPNPKTRIQIQGIKKD 261 + E+ L+ R ++ +P R + I +D Sbjct: 258 TPSCKELADLMTRCMNYDPNQRPFFRAIMRD 288 >4IAN-A nrPDB Length = 358 Score = 55.8 bits (133), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 52/211 (24%), Positives = 96/211 (45%), Gaps = 17/211 (8%) Query: 10 KYEVGRTIGEGTFAKVKFAR-NTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 +Y V G+G F+ V AR N VA+KI+ + +++ + +E+ +K + Sbjct: 31 RYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTGL----KELEFLKKLND 86 Query: 69 PN------IVRLYEVLASPSKIYIVLEFVTGG--ELFDRIVHKGRLEESESRKYFQQLVD 120 + +RL+ + +V E ++ E+ + L R Y QQL Sbjct: 87 ADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGLHIKAVRSYSQQLFL 146 Query: 121 AVAHCHCKGVYHRDLKPENLLLDTNGN-LKVSDFGLSALPQEGVELLRTTCGTPNYVAPE 179 A+ + H D+KP+N+L++ + LK+ DFG ++ + + + Y APE Sbjct: 147 ALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVADND--ITPYLVSRFYRAPE 204 Query: 180 VLSGQGYDGSAADIWSCGVILFVILAGYLPF 210 ++ G+ YD D+WS G L+ + G + F Sbjct: 205 IIIGKSYD-YGIDMWSVGCTLYELYTGKILF 234 >5XD6-A nrPDB Length = 305 Score = 55.1 bits (131), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 61/213 (28%), Positives = 94/213 (44%), Gaps = 24/213 (11%) Query: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYE 76 IGEG++ +V F +G AIK + S + Q+ S++ +R N+V L Sbjct: 30 IGEGSYGRV-FYGILKSGKAAAIKKLDSSKQPDQEFLAQV----SMVSRLRQENVVALLG 84 Query: 77 VLASPSKIYIVLEFVTGGELFDRIVHKGR-----LEESESRKYFQQLVDAVA------HC 125 + E+ G L D I+H GR + + Q++ AV + Sbjct: 85 YCVDGPLRVLAYEYAPNGSLHD-ILH-GRKGVKGAQPGPVLSWHQRVKIAVGAARGLEYL 142 Query: 126 HCKG---VYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTT--CGTPNYVAPEV 180 H K V HRD+K N+LL + K++DF LS + L +T GT Y APE Sbjct: 143 HEKANPHVIHRDIKSSNVLLFDDDVAKIADFDLSNQAPDMAARLHSTRVLGTFGYHAPE- 201 Query: 181 LSGQGYDGSAADIWSCGVILFVILAGYLPFSET 213 + G + +D++S GV+L +L G P T Sbjct: 202 YAMTGTLSTKSDVYSFGVVLLELLTGRKPVDHT 234 >3PP0-A nrPDB Length = 338 Score = 54.3 bits (129), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 40/149 (26%), Positives = 74/149 (49%), Gaps = 8/149 (5%) Query: 15 RTIGEGTFAKVKFARNTDTGDNV----AIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 + +G G F V G+NV AIK++ ++T K +I E +M V P Sbjct: 23 KVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKAN--KEILDEAYVMAGVGSPY 80 Query: 71 IVRLYEVLASPSKIYIVLEFVTGGELFDRI-VHKGRLEESESRKYFQQLVDAVAHCHCKG 129 + RL + + S + +V + + G L D + ++GRL + + Q+ +++ Sbjct: 81 VSRLLGICLT-STVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVR 139 Query: 130 VYHRDLKPENLLLDTNGNLKVSDFGLSAL 158 + HRDL N+L+ + ++K++DFGL+ L Sbjct: 140 LVHRDLAARNVLVKSPNHVKITDFGLARL 168 >5GRN-A nrPDB Length = 356 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 68/284 (23%), Positives = 121/284 (42%), Gaps = 54/284 (19%) Query: 13 VGRTIGEGTFAKVKFARNTDTGDN-------VAIKIMAKSTILKNRMVDQIKREISIM-K 64 +GR +G G F KV T G + VA+K++ + ++ + E+ IM Sbjct: 50 LGRVLGSGAFGKV--VEGTAYGLSRSQPVMKVAVKMLKPTA--RSSEKQALMSELKIMTH 105 Query: 65 IVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGR----------LEESESRKY 114 + H NIV L IYI+ E+ G+L + + HK R + +SE + Sbjct: 106 LGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYL-HKNRDSFLSHKKKSMLDSEVKNL 164 Query: 115 FQQ-------LVDAVAHCH----------CKGVYHRDLKPENLLLDTNGNLKVSDFGLS- 156 L+D ++ + K HRDL N+LL +K+ DFGL+ Sbjct: 165 LSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLAR 224 Query: 157 ALPQEGVELLRTTCGTP-NYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDL 215 + + + + + P ++APE + Y + +D+WS G++L+ I + T Sbjct: 225 DIMHDSNYVSKGSTFLPVKWMAPESIFDNLYT-TLSDVWSYGILLWEIFS----LGGTPY 279 Query: 216 PGL------YRKINAA-EFSCPPWFSAEVKFLIHRILDPNPKTR 252 PG+ Y KI + + P ++EV ++ + + P+ R Sbjct: 280 PGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKR 323 >5C26-A nrPDB Length = 299 Score = 53.9 bits (128), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 44/163 (26%), Positives = 78/163 (47%), Gaps = 10/163 (6%) Query: 47 ILKNR-----MVDQIKREISIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIV 101 ILKN + D++ E ++M+ + +P IVR+ + + S + +V+E G L + Sbjct: 61 ILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWM-LVMEMAELGPLNKYLQ 119 Query: 102 HKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSAL--P 159 +++ + Q+ + + HRDL N+LL T K+SDFGLS Sbjct: 120 QNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRA 179 Query: 160 QEGVELLRTTCGTP-NYVAPEVLSGQGYDGSAADIWSCGVILF 201 E +T P + APE ++ + S +D+WS GV+++ Sbjct: 180 DENYYKAQTHGKWPVKWYAPECINYYKF-SSKSDVWSFGVLMW 221 >5HLW-A nrPDB Length = 299 Score = 53.5 bits (127), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 57/207 (27%), Positives = 92/207 (44%), Gaps = 11/207 (5%) Query: 17 IGEGTFAKVKFARNTDT-GDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLY 75 IG G F V D G + + + + I V Q E IMK HPN++ L Sbjct: 28 IGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLL 87 Query: 76 EV-LASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQ-QLVDAVAHCHCKGVYHR 133 + L S +VL ++ G+L + I ++ + F Q+ + + K HR Sbjct: 88 GICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHR 147 Query: 134 DLKPENLLLDTNGNLKVSDFGLSALPQEGVELL----RTTCGTP-NYVAPEVLSGQGYDG 188 DL N +LD +KV+DFGL A E +T P ++A E L Q + Sbjct: 148 DLAARNCMLDEKFTVKVADFGL-ARDMHDKEYYSVHNKTGAKLPVKWMALESLQTQKFT- 205 Query: 189 SAADIWSCGVILFVILA-GYLPFSETD 214 + +D+WS GV+L+ ++ G P+ + + Sbjct: 206 TKSDVWSFGVLLWELMTRGAPPYPDVN 232 >1PY5-A nrPDB Length = 326 Score = 53.5 bits (127), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 54/211 (25%), Positives = 95/211 (45%), Gaps = 32/211 (15%) Query: 16 TIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIV--RHPNIVR 73 +IG+G F +V R G+ VA+KI + +R RE I + V RH NI+ Sbjct: 36 SIGKGRFGEV--WRGKWRGEEVAVKIFS------SREERSWFREAEIYQTVMLRHENILG 87 Query: 74 LYEV----LASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCK- 128 + +++++V ++ G LFD +++ + K +AH H + Sbjct: 88 FIAADNKDNGTWTQLWLVSDYHEHGSLFD-YLNRYTVTVEGMIKLALSTASGLAHLHMEI 146 Query: 129 -------GVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTT----CGTPNYVA 177 + HRDLK +N+L+ NG ++D GL+ + + GT Y+A Sbjct: 147 VGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMA 206 Query: 178 PEVLSG----QGYDG-SAADIWSCGVILFVI 203 PEVL + ++ ADI++ G++ + I Sbjct: 207 PEVLDDSINMKHFESFKRADIYAMGLVFWEI 237 >3C1X-A nrPDB Length = 373 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 54/206 (26%), Positives = 92/206 (44%), Gaps = 9/206 (4%) Query: 17 IGEGTFAKVKFARNTDT-GDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLY 75 IG G F V D G + + + + I V Q E IMK HPN++ L Sbjct: 97 IGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLL 156 Query: 76 EV-LASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQ-QLVDAVAHCHCKGVYHR 133 + L S +VL ++ G+L + I ++ + F Q+ + K HR Sbjct: 157 GICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKFLASKKFVHR 216 Query: 134 DLKPENLLLDTNGNLKVSDFGLS-ALPQEGVELLRTTCGTP---NYVAPEVLSGQGYDGS 189 DL N +LD +KV+DFGL+ + + + + G ++A E L Q + + Sbjct: 217 DLAARNCMLDEKFTVKVADFGLARDMYDKEFDSVHNKTGAKLPVKWMALESLQTQKFT-T 275 Query: 190 AADIWSCGVILFVILA-GYLPFSETD 214 +D+WS GV+L+ ++ G P+ + + Sbjct: 276 KSDVWSFGVLLWELMTRGAPPYPDVN 301 >1LUF-A nrPDB Length = 343 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 58/236 (24%), Positives = 101/236 (42%), Gaps = 45/236 (19%) Query: 12 EVGRTIGEGTFAKVKFARNT-----DTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIV 66 E R IGEG F +V AR + VA+K++ + M +RE ++M Sbjct: 50 EYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEA--SADMQADFQREAALMAEF 107 Query: 67 RHPNIVRLYEVLASPSKIYIVLEFVTGGELFD----------------------RIVHKG 104 +PNIV+L V A + ++ E++ G+L + R+ G Sbjct: 108 DNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRARVSSPG 167 Query: 105 R--LEESESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLS------ 156 L +E +Q+ +A+ + HRDL N L+ N +K++DFGLS Sbjct: 168 PPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSA 227 Query: 157 -ALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILA-GYLPF 210 +G + + ++ PE + Y + +D+W+ GV+L+ I + G P+ Sbjct: 228 DYYKADGNDAIPI-----RWMPPESIFYNRYT-TESDVWAYGVVLWEIFSYGLQPY 277 >3G0E-A nrPDB Length = 336 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 62/274 (22%), Positives = 111/274 (40%), Gaps = 32/274 (11%) Query: 14 GRTIGEGTFAKVKFAR-----NTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIV-R 67 G+T+G G F KV A +D VA+K++ S L R + + E+ ++ + Sbjct: 51 GKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTER--EALMSELKVLSYLGN 108 Query: 68 HPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHK------------------GRLEES 109 H NIV L ++ E+ G+L + + K L+ Sbjct: 109 HMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKTSPAIMEDDELALDLE 168 Query: 110 ESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLS-ALPQEGVELLRT 168 + + Q+ +A K HRDL N+LL K+ DFGL+ + + +++ Sbjct: 169 DLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKG 228 Query: 169 TCGTP-NYVAPEVLSGQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAAE 226 P ++APE + Y +D+WS G+ L+ + + G P+ + + K+ Sbjct: 229 NARLPVKWMAPESIFNCVYTFE-SDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEG 287 Query: 227 FS--CPPWFSAEVKFLIHRILDPNPKTRIQIQGI 258 F P AE+ ++ D +P R + I Sbjct: 288 FRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQI 321 >5GNK-A nrPDB Length = 297 Score = 53.1 bits (126), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 59/262 (22%), Positives = 113/262 (43%), Gaps = 16/262 (6%) Query: 15 RTIGEGTFAKVKFARNTDTGDNVAIKIMAKST--ILKNRMVDQIKREISIMKIVRHPNIV 72 + +G G F V G+ V I + K + +I E +M V +P++ Sbjct: 25 KVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVC 84 Query: 73 RLYEVLASPSKIYIVLEFVTGGELFDRI-VHKGRLEESESRKYFQQLVDAVAHCHCKGVY 131 RL + + S + ++++ + G L D + HK + + Q+ + + + + Sbjct: 85 RLLGICLT-STVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLV 143 Query: 132 HRDLKPENLLLDTNGNLKVSDFGLSA-LPQEGVELLRTTCGTP-NYVAPEVLSGQGYDGS 189 HRDL N+L+ T ++K++DFGL+ L E E P ++A E + + Y Sbjct: 144 HRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYT-H 202 Query: 190 AADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAAE-FSCPPWFSAEVKFLIHRIL-- 245 +D+WS GV ++ ++ G P+ + + E PP + +V ++ + Sbjct: 203 QSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMI 262 Query: 246 --DPNPKTR---IQIQGIKKDP 262 D PK R I+ + +DP Sbjct: 263 DADSRPKFRELIIEFSKMARDP 284 >3RAW-A nrPDB Length = 381 Score = 53.1 bits (126), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 59/231 (25%), Positives = 95/231 (41%), Gaps = 39/231 (16%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTG-DNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 +YE+ +GEGTF KV + G VA+KI+ + K R + + EI+++K ++ Sbjct: 52 RYEIVGNLGEGTFGKVVECLDHARGKSQVALKII--RNVGKYR--EAARLEINVLKKIKE 107 Query: 69 PN------IVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEE---SESRKYFQQLV 119 + V + + + I E + G F+ + + + R QL Sbjct: 108 KDKENKFLCVLMSDWFNFHGHMCIAFELL-GKNTFE-FLKENNFQPYPLPHVRHMAYQLC 165 Query: 120 DAVAHCHCKGVYHRDLKPENLLLDT-------------------NGNLKVSDFGLSALPQ 160 A+ H + H DLKPEN+L N +++V+DFG + Sbjct: 166 HALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDH 225 Query: 161 EGVELLRTTCGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFS 211 E T T +Y PEV+ G+ D+WS G ILF G+ F Sbjct: 226 EH---HTTIVATRHYRPPEVILELGW-AQPCDVWSIGCILFEYYRGFTLFQ 272 >5OAT-A nrPDB Length = 411 Score = 52.8 bits (125), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 46/163 (28%), Positives = 70/163 (42%), Gaps = 41/163 (25%) Query: 120 DAVAHCHCKGVYHRDLKPENLLLDTNGN----LKVSDFGLS--------ALPQEGVELLR 167 + VAH G+ HRDLK +NLLLDT+ L +SDFG +LP E+ + Sbjct: 164 EGVAHMTAHGIAHRDLKSDNLLLDTSEPESPILVISDFGCCLADKTNGLSLPYTSYEMDK 223 Query: 168 TTCGTPNYVAPEVLSGQG-----YDGSAADIWSCGVILFVILAGYLPF-----------S 211 G +APE++ + + S AD+W+ G I + I + PF Sbjct: 224 G--GNTALMAPEIICQKPGTFSVLNYSKADLWAVGAIAYEIFNCHNPFYGPSRLKNFNYK 281 Query: 212 ETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILDPNPKTRIQ 254 E DLP L ++ ++ L+ +L NP R+ Sbjct: 282 EGDLPKLPDEVPTV-----------IQALVANLLKRNPNKRLD 313 >4FL3-A nrPDB Length = 635 Score = 52.8 bits (125), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 44/163 (26%), Positives = 78/163 (47%), Gaps = 10/163 (6%) Query: 47 ILKNR-----MVDQIKREISIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIV 101 ILKN + D++ E ++M+ + +P IVR+ + + S + +V+E G L + Sbjct: 403 ILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWM-LVMEMAELGPLNKYLQ 461 Query: 102 HKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSAL--P 159 +++ + Q+ + + HRDL N+LL T K+SDFGLS Sbjct: 462 QNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRA 521 Query: 160 QEGVELLRTTCGTP-NYVAPEVLSGQGYDGSAADIWSCGVILF 201 E +T P + APE ++ + S +D+WS GV+++ Sbjct: 522 DENYYKAQTHGKWPVKWYAPECINYYKFS-SKSDVWSFGVLMW 563 >3LZB-A nrPDB Length = 327 Score = 52.8 bits (125), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 59/262 (22%), Positives = 112/262 (42%), Gaps = 16/262 (6%) Query: 15 RTIGEGTFAKVKFARNTDTGDNVAIKIMAKST--ILKNRMVDQIKREISIMKIVRHPNIV 72 + +G G F V G+ V I + K + +I E +M V +P++ Sbjct: 21 KVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVC 80 Query: 73 RLYEVLASPSKIYIVLEFVTGGELFDRI-VHKGRLEESESRKYFQQLVDAVAHCHCKGVY 131 RL + + S + ++ + + G L D + HK + + Q+ + + + + Sbjct: 81 RLLGICLT-STVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLV 139 Query: 132 HRDLKPENLLLDTNGNLKVSDFGLSA-LPQEGVELLRTTCGTP-NYVAPEVLSGQGYDGS 189 HRDL N+L+ T ++K++DFGL+ L E E P ++A E + + Y Sbjct: 140 HRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYT-H 198 Query: 190 AADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAAE-FSCPPWFSAEVKFLIHRIL-- 245 +D+WS GV ++ ++ G P+ + + E PP + +V ++ + Sbjct: 199 QSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMRKCWMI 258 Query: 246 --DPNPKTR---IQIQGIKKDP 262 D PK R I+ + +DP Sbjct: 259 DADSRPKFRELIIEFSKMARDP 280 >3MDY-A nrPDB Length = 337 Score = 52.0 bits (123), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 52/210 (24%), Positives = 93/210 (44%), Gaps = 32/210 (15%) Query: 15 RTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRL 74 + IG+G + +V + G+ VA+K+ + +I + + ++RH NI+ Sbjct: 43 KQIGKGRYGEVWMGKWR--GEKVAVKVFFTTEEASWFRETEIYQTV----LMRHENILGF 96 Query: 75 YEV----LASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCK-- 128 S +++Y++ ++ G L+D + L+ K V + H H + Sbjct: 97 IAADIKGTGSWTQLYLITDYHENGSLYDYL-KSTTLDAKSMLKLAYSSVSGLCHLHTEIF 155 Query: 129 ------GVYHRDLKPENLLLDTNGNLKVSDFGLSA-LPQEGVEL---LRTTCGTPNYVAP 178 + HRDLK +N+L+ NG ++D GL+ + E+ T GT Y+ P Sbjct: 156 STQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPP 215 Query: 179 EVLSG-------QGYDGSAADIWSCGVILF 201 EVL Q Y AD++S G+IL+ Sbjct: 216 EVLDESLNRNHFQSY--IMADMYSFGLILW 243 >6J6I-B nrPDB Length = 351 Score = 51.6 bits (122), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 52/206 (25%), Positives = 86/206 (41%), Gaps = 27/206 (13%) Query: 26 KFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYEVLASPSKIY 85 +F+ + TG +K + +L RM + H N ++L Sbjct: 88 RFSEDEITGKRHRVKEVYNDIVLSARMSN-------------HSNFLQLLGCCLEFPFPV 134 Query: 86 IVLEFVTGGELFDR--IVHKGR---LEESESRKYFQQLVDAVAHCHC---KGVYHRDLKP 137 +V EF G + R ++ G L S K +++ +AV + H K + HRD+KP Sbjct: 135 LVFEFAEHGAMNQRGGVIVNGEESLLPWSVRLKIGKEIANAVTYLHTAFPKIIIHRDVKP 194 Query: 138 ENLLLDTNGNLKVSDFGLSALPQEGVELLRT--TCGTPNYVAPEVLSGQGYDGSAADIWS 195 ++ LD N K+SD S EG + GT Y+ P + + D++S Sbjct: 195 MHVFLDKNWTAKLSDLSFSISLPEGKSRIEAEWVLGTFGYIDP-LYHKTCFVTEYTDVYS 253 Query: 196 CGVILFVILAG---YLPFSETDLPGL 218 G+ L VI+ G + S+ DL G+ Sbjct: 254 FGICLLVIITGKPAIMTISDGDLQGI 279 >3SV0-A nrPDB Length = 483 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 60/220 (27%), Positives = 96/220 (43%), Gaps = 26/220 (11%) Query: 7 RVG-KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKI 65 RVG K+ +GR IG G+F ++ N T + VAIK+ T Q+ E I +I Sbjct: 4 RVGNKFRLGRKIGSGSFGEIYLGTNIQTNEEVAIKLENVKT-----KHPQLLYESKIYRI 58 Query: 66 VRH----PNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDA 121 ++ PN VR + V + + + L + +LF+ K L Q+++ Sbjct: 59 LQGGTGIPN-VRWFGVEGDYNVLVMDLLGPSLEDLFNFCSRK--LSLKTVLMLADQMINR 115 Query: 122 VAHCHCKGVYHRDLKPENLLLDTN---GNLKVSDFGLSALPQEGVELL-------RTTCG 171 V H K HRD+KP+N L+ + + DFGL+ ++ + G Sbjct: 116 VEFVHSKSFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDTSTHQHIPYRENKNLTG 175 Query: 172 TPNYVAPEVLSGQGYDGS-AADIWSCGVILFVILAGYLPF 210 T Y + V + G + S D+ S G +L L G LP+ Sbjct: 176 TARYAS--VNTHLGIEQSRRDDLESLGYVLMYFLRGSLPW 213 >6FEX-A nrPDB Length = 321 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 54/220 (24%), Positives = 96/220 (43%), Gaps = 36/220 (16%) Query: 17 IGEGTFAKVK--------------FARNTDTGDN--VAIKIMAKSTILKNRMVDQIKREI 60 +GEG F +V F N G VA+KI+ + KN D +K E+ Sbjct: 24 LGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKIL-RPDATKNARNDFLK-EV 81 Query: 61 SIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESR-------- 112 IM ++ PNI+RL V + ++ +++ G+L ++ + +LE+ + Sbjct: 82 KIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDL-NQFLSAHQLEDKAAEGAPGDPTI 140 Query: 113 ------KYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLS-ALPQEGVEL 165 Q+ + + HRDL N L+ N +K++DFG+S L Sbjct: 141 SYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYR 200 Query: 166 LRTTCGTP-NYVAPEVLSGQGYDGSAADIWSCGVILFVIL 204 ++ P ++A E + G +A+D+W+ GV L+ +L Sbjct: 201 VQGRAVLPIRWMAWECIL-MGKFTTASDVWAFGVTLWEVL 239 >3AOX-A nrPDB Length = 344 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 73/307 (23%), Positives = 115/307 (37%), Gaps = 35/307 (11%) Query: 15 RTIGEGTFAKVKFAR-----NTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 R +G G F +V + N + VA+K + + ++ + E I+ H Sbjct: 53 RGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDEL--DFLMEALIISKFNHQ 110 Query: 70 NIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAH---CH 126 NIVR V +I+LE + GG+L + + R S+ + VA C Sbjct: 111 NIVRCIGVSLQSLPRFILLELMAGGDL-KSFLRETRPRPSQPSSLAMLDLLHVARDIACG 169 Query: 127 CKGV-----YHRDLKPENLLLDTNGN---LKVSDFGLSALPQEGVELLRTTCG--TPNYV 176 C+ + HRD+ N LL G K+ DFG++ + C ++ Sbjct: 170 CQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWM 229 Query: 177 APEVLSGQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAAEFSCPPWFSA 235 PE +G S D WS GV+L+ I + GY+P+ + + + PP Sbjct: 230 PPEAFM-EGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNC- 287 Query: 236 EVKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEVNLDDIRAVFDGIEGSY 295 P P RI Q + P R N+ I R E D+ IE Sbjct: 288 -----------PGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGP 336 Query: 296 VAENVER 302 + E E+ Sbjct: 337 LVEEEEK 343 >3REP-A nrPDB Length = 271 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 50/241 (20%), Positives = 108/241 (44%), Gaps = 28/241 (11%) Query: 34 GDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYEVLASPSKIY--IVLEFV 91 G+++ +K++ K R E ++I HPN++ + SP + ++ ++ Sbjct: 33 GNDIVVKVL-KVRDWSTRKSRDFNEECPRLRIFSHPNVLPVLGACQSPPAPHPTLITHWM 91 Query: 92 TGGELFDRIVHKGR---LEESESRKYFQQLVDAVAHCHC--KGVYHRDLKPENLLLDTNG 146 G L++ ++H+G +++S++ K+ + +A H + L ++++D + Sbjct: 92 PYGSLYN-VLHEGTNFVVDQSQAVKFALDMARGMAFLHTLEPLIPRHALNSRSVMIDEDM 150 Query: 147 NLKVSDFGLSALPQEGVELLRTTCG---TPNYVAPEVLSGQGYDGS--AADIWSCGVILF 201 ++S V+ + G P +VAPE L + D + +AD+WS V+L+ Sbjct: 151 TARIS--------MADVKFSFQSPGRMYAPAWVAPEALQKKPEDTNRRSADMWSFAVLLW 202 Query: 202 VILAGYLPFSETDLP----GLYRKINAAEFSCPPWFSAEVKFLIHRILDPNPKTRIQIQG 257 ++ +PF+ DL G+ + + PP S V L+ ++ +P R + Sbjct: 203 ELVTREVPFA--DLSNMEIGMKVALEGLRPTIPPGISPHVSKLMKICMNEDPAKRPKFDM 260 Query: 258 I 258 I Sbjct: 261 I 261 >5X18-A nrPDB Length = 295 Score = 49.3 bits (116), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 54/220 (24%), Positives = 92/220 (41%), Gaps = 21/220 (9%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH-P 69 Y++G+ IGEG+F + N G VAIK + T Q++ E KI+ P Sbjct: 9 YKIGKKIGEGSFGVLFEGTNMINGVPVAIKFEPRKT-----EAPQLRDEYKTYKILNGTP 63 Query: 70 NIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGR-LEESESRKYFQQLVDAVAHCHCK 128 NI Y +V++ + G L D GR + Q++ + H Sbjct: 64 NIPYAYYFGQEGLHNILVIDLL-GPSLEDLFDWCGRKFSVKTVVQVAVQMITLIEDLHAH 122 Query: 129 GVYHRDLKPENLLLDTNG-----NLKVSDFGLSAL---PQEGVEL----LRTTCGTPNYV 176 + +RD+KP+N L+ G N+ + DFG++ P+ + ++ GT Y+ Sbjct: 123 DLIYRDIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRDPKTKQHIPYREKKSLSGTARYM 182 Query: 177 APEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLP 216 + G+ D+ + G + F L G+LP+ P Sbjct: 183 SINTHLGRE-QSRRDDMEALGHVFFYFLRGHLPWQGLKAP 221 >3LLT-A nrPDB Length = 360 Score = 48.9 bits (115), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 56/229 (24%), Positives = 95/229 (41%), Gaps = 39/229 (17%) Query: 13 VGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIV 72 V R +G+GTF +V ++ D A+K++ + K E I+K +++ +I Sbjct: 39 VIRKMGDGTFGRVLLCQHIDNKKYYAVKVVRNI----KKYTRSAKIEADILKKIQNDDIN 94 Query: 73 RLYEVLASPSKIY---IVLEFVTGGELFDRIVHKGR---LEESESRKYFQQLVDAVAHCH 126 V +Y + L F G I+ + + + Y +++ A+ + Sbjct: 95 NNNIVKYHGKFMYYDHMCLIFEPLGPSLYEIITRNNYNGFHIEDIKLYCIEILKALNYLR 154 Query: 127 CKGVYHRDLKPENLLLD--------------TNGN-----------LKVSDFGLSALPQE 161 + H DLKPEN+LLD T+G +K+ DFG + Sbjct: 155 KMSLTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTKSTGIKLIDFGCATFKS- 213 Query: 162 GVELLRTTCGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPF 210 + + T Y APEV+ G+D S +D+WS G +L + G L F Sbjct: 214 --DYHGSIINTRQYRAPEVILNLGWDVS-SDMWSFGCVLAELYTGSLLF 259 >5E8V-A nrPDB Length = 316 Score = 48.9 bits (115), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 50/193 (25%), Positives = 86/193 (44%), Gaps = 26/193 (13%) Query: 12 EVGRTIGEGTFAKV---KFARNT-DTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR 67 E+ +G+G FA+V K +NT + + VA+KI + I +I++ + Sbjct: 12 ELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINL----K 67 Query: 68 HPNIVRLYEVLASPSKI----YIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVA 123 H NI++ +++ +++ F G L + + + + + RK L +A Sbjct: 68 HENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLT-RHVISWEDLRKLGSSLARGIA 126 Query: 124 HCHCKG---------VYHRDLKPENLLLDTNGNLKVSDFGLSAL--PQEGVELLRTT--C 170 H H + HRDLK N+L+ + + DFGLS P V+ L + Sbjct: 127 HLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQV 186 Query: 171 GTPNYVAPEVLSG 183 GT Y+APEVL+ Sbjct: 187 GTARYMAPEVLAS 199 >2ZFD-B nrPDB Length = 123 Score = 48.9 bits (115), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 31/101 (30%), Positives = 53/101 (52%), Gaps = 6/101 (5%) Query: 306 GPLMMNAFEMITLSQGLNLSALFDRRQDFVKRQTRFVSRREPSEIIANIEAVANSMGFK- 364 G MNAF++I+ S G NLS LF + + R RFVS ++ +E + ++ Sbjct: 2 GARRMNAFDIISGSPGFNLSGLFGDARKY-DRVERFVSAWTAERVVERLEEIVSAENLTV 60 Query: 365 SHTRNFKTRLEGLSSIKAGQLAVVIEIYEVAPSLFMVDVRK 405 + + ++EG + G A+V+EI ++ L M++VRK Sbjct: 61 AKKETWGMKIEG----QKGNFAMVVEINQLTDELVMIEVRK 97 >3CJF-A nrPDB Length = 309 Score = 48.5 bits (114), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 53/222 (23%), Positives = 94/222 (42%), Gaps = 23/222 (10%) Query: 10 KYEVGRTIGEGTFAKVKFAR-----NTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMK 64 + +G+ +G G F +V A T T VA+K++ + + +I ++ Sbjct: 28 RLNLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKI-LIH 86 Query: 65 IVRHPNIVRLYEVLASPS-KIYIVLEFVTGGELFDRI------------VHKGRLEESES 111 I H N+V L P + +++EF G L + ++K L Sbjct: 87 IGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKDLYKDFLTLEHL 146 Query: 112 RKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRT-TC 170 Y Q+ + + HRDL N+LL +K+ DFGL+ + + +R Sbjct: 147 ICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDA 206 Query: 171 GTP-NYVAPEVLSGQGYDGSAADIWSCGVILFVILA-GYLPF 210 P ++APE + + Y +D+WS GV+L+ I + G P+ Sbjct: 207 RLPLKWMAPETIFDRVYT-IQSDVWSFGVLLWEIFSLGASPY 247 >3ZBF-A nrPDB Length = 322 Score = 48.5 bits (114), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 58/225 (25%), Positives = 94/225 (41%), Gaps = 44/225 (19%) Query: 17 IGEGTFAKVKFARNTD-----TGD-NVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 +G G F +V D +G+ VA+K + K + + ++ + +E +M HPN Sbjct: 41 LGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKI--EFLKEAHLMSKFNHPN 98 Query: 71 IVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLE-----ESESRKYFQQLVDAVAHC 125 I++ V YI+LE + GG+L + K R+ VD C Sbjct: 99 ILKQLGVCLLNEPQYIILELMEGGDLLTYL-RKARMATFYGPLLTLVDLVDLCVDISKGC 157 Query: 126 HCKGVY-------HRDLKPENLLLDTNGN-----LKVSDFGLS-------ALPQEGVELL 166 VY HRDL N L+ +K+ DFGL+ + G LL Sbjct: 158 ----VYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLL 213 Query: 167 RTTCGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILA-GYLPF 210 ++APE L G + +D+WS G++++ IL G+ P+ Sbjct: 214 PV-----RWMAPESLM-DGIFTTQSDVWSFGILIWEILTLGHQPY 252 >6BFN-A nrPDB Length = 342 Score = 48.1 bits (113), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 61/210 (29%), Positives = 88/210 (41%), Gaps = 27/210 (12%) Query: 17 IGEGTFAKVKFA--RNTDTGDNVAIKIMAKSTILKNRMVDQ-IKREISIMKIVRHPNIVR 73 IGEG F V A RNT A+K + ++ L+ V Q E+ + RHPNIV Sbjct: 30 IGEGGFGCVYRAVMRNT----VYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVD 85 Query: 74 LYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQL------VDAVAHCH- 126 A +V F+ G L DR+ + + + Q+L A+ H Sbjct: 86 FAGYCAQNGFYCLVYGFLPNGSLEDRL--HCQTQACPPLSWPQRLDILLGTARAIQFLHQ 143 Query: 127 -CKGVYHRDLKPENLLLDTNGNLKVSDFGLS-------ALPQEGVELLRTTC--GTPNYV 176 + H D+K N+LLD K+ DFGL+ + P + + RT GT Y+ Sbjct: 144 DSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYL 203 Query: 177 APEVLSGQGYDGSAADIWSCGVILFVILAG 206 PE G D +S GV++ LAG Sbjct: 204 -PEEYIKTGRLAVDTDTFSFGVVVLETLAG 232 >6FER-A nrPDB Length = 309 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 50/210 (23%), Positives = 94/210 (44%), Gaps = 19/210 (9%) Query: 7 RVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKI-MAKSTILKNRMVDQIKREISIMKI 65 + G+ + G F FA + V + + M ++ KN D +K EI IM Sbjct: 21 QFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLK-EIKIMSR 79 Query: 66 VRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESR----------KYF 115 ++ PNI+ L V + + ++ E++ G+L ++ + + S S K+ Sbjct: 80 LKDPNIIHLLAVCITDDPLCMITEYMENGDL-NQFLSRHEPPNSSSSDVRTVSYTNLKFM 138 Query: 116 -QQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLS-ALPQEGVELLRTTCGTP 173 Q+ + + HRDL N L+ N +K++DFG+S L ++ P Sbjct: 139 ATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYYRIQGRAVLP 198 Query: 174 -NYVAPE-VLSGQGYDGSAADIWSCGVILF 201 +++ E +L G+ +A+D+W+ GV L+ Sbjct: 199 IRWMSWESILLGKF--TTASDVWAFGVTLW 226 >6BSD-A nrPDB Length = 876 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 54/226 (23%), Positives = 96/226 (42%), Gaps = 42/226 (18%) Query: 17 IGEGTFAKVK--------------FARNTDTGDN--VAIKIMAKSTILKNRMVDQIKREI 60 +GEG F +V F N G VA+KI+ + KN D +K E+ Sbjct: 579 LGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKIL-RPDATKNARNDFLK-EV 636 Query: 61 SIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESR-------- 112 IM ++ PNI+RL V + ++ +++ G+L ++ + +LE+ + Sbjct: 637 KIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDL-NQFLSAHQLEDKAAEGAPGDGQA 695 Query: 113 ------------KYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQ 160 Q+ + + HRDL N L+ N +K++DFG+S Sbjct: 696 AQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLY 755 Query: 161 EG-VELLRTTCGTP-NYVAPEVLSGQGYDGSAADIWSCGVILFVIL 204 G ++ P ++A E + G +A+D+W+ GV L+ +L Sbjct: 756 AGDYYRVQGRAVLPIRWMAWECIL-MGKFTTASDVWAFGVTLWEVL 800 >4NFN-A nrPDB Length = 309 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 53/216 (24%), Positives = 94/216 (43%), Gaps = 24/216 (11%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 +++V + IG G F ++ A + T +NVA+K+ + + + V +K E++++K ++ Sbjct: 22 RWKVLKKIGGGGFGEIYEAMDLLTRENVALKV---ESAQQPKQV--LKMEVAVLKKLQGK 76 Query: 70 NIVRLYEVLASPSKIYIVLEFVTGGELFD--RIVHKGRLEESESRKYFQQLVDAVAHCHC 127 + V + K V+ + G L D R +G S + + +Q+++++ H Sbjct: 77 DHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHS 136 Query: 128 KGVYHRDLKPENL----LLDTNGNLKVSDFGLS---------ALPQEGVELLRTTCGTPN 174 G HRD+KP N L T + DFGL+ P V R GT Sbjct: 137 VGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFR---GTVR 193 Query: 175 YVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPF 210 Y + + G D+WS +L G LP+ Sbjct: 194 YASVNAHKNREM-GRHDDLWSLFYMLVEFAVGQLPW 228 >4BTK-A nrPDB Length = 337 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 53/216 (24%), Positives = 94/216 (43%), Gaps = 24/216 (11%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 +++V + IG G F ++ A + T +NVA+K+ + + + V +K E++++K ++ Sbjct: 57 RWKVLKKIGGGGFGEIYEAMDLLTRENVALKV---ESAQQPKQV--LKMEVAVLKKLQGK 111 Query: 70 NIVRLYEVLASPSKIYIVLEFVTGGELFD--RIVHKGRLEESESRKYFQQLVDAVAHCHC 127 + V + K V+ + G L D R +G S + + +Q+++++ H Sbjct: 112 DHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHS 171 Query: 128 KGVYHRDLKPENL----LLDTNGNLKVSDFGLS---------ALPQEGVELLRTTCGTPN 174 G HRD+KP N L T + DFGL+ P V R GT Sbjct: 172 VGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFR---GTVR 228 Query: 175 YVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPF 210 Y + + G D+WS +L G LP+ Sbjct: 229 YASVNAHKNREM-GRHDDLWSLFYMLVEFAVGQLPW 263 >4TN6-A nrPDB Length = 318 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 45/162 (27%), Positives = 71/162 (43%), Gaps = 24/162 (14%) Query: 7 RVG-KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKI 65 RVG +Y +GR IG G+F + + G+ VAIK+ T Q+ E I K+ Sbjct: 4 RVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKT-----KHPQLHIESKIYKM 58 Query: 66 VRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKY--------FQQ 117 ++ + + +++ + G L D L SRK+ Q Sbjct: 59 MQGGVGIPTIRWCGAEGDYNVMVMELLGPSLED-------LFNFCSRKFSLKTVLLLADQ 111 Query: 118 LVDAVAHCHCKGVYHRDLKPENLL--LDTNGNL-KVSDFGLS 156 ++ + + H K HRD+KP+N L L GNL + DFGL+ Sbjct: 112 MISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLA 153 >5FQD-C nrPDB Length = 341 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 45/177 (25%), Positives = 72/177 (40%), Gaps = 59/177 (33%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 GKY++ R IG G+F + A N G+ VA+K+ ++ RH Sbjct: 19 GKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQK--------------------ARH 58 Query: 69 PNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESE------------------ 110 P + LYE SK+Y +L+ GG I G+ ++ Sbjct: 59 PQL--LYE-----SKLYKILQ---GGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFC 108 Query: 111 SRKYF--------QQLVDAVAHCHCKGVYHRDLKPENLLLDTN---GNLKVSDFGLS 156 SR++ Q++ + + H K HRD+KP+N L+ L + DFGL+ Sbjct: 109 SRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLA 165 >5KMM-A nrPDB Length = 329 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 48/208 (23%), Positives = 89/208 (42%), Gaps = 22/208 (10%) Query: 17 IGEGTFAKVKFARNTDT---GDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVR 73 +GEG F KV A + D + + + A ++ D +RE ++ +++H +IVR Sbjct: 43 LGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQD-FQREAELLTMLQHQHIVR 101 Query: 74 LYEVLASPSKIYIVLEFVTGGELF--------DRIVHKGRLEESESRKYFQQLVDAVAHC 125 + V + +V E++ G+L D + G + + QL+ + Sbjct: 102 FFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQV 161 Query: 126 HCKGVY-------HRDLKPENLLLDTNGNLKVSDFGLS--ALPQEGVELLRTTCGTPNYV 176 VY HRDL N L+ +K+ DFG+S + + T ++ Sbjct: 162 AAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWM 221 Query: 177 APEVLSGQGYDGSAADIWSCGVILFVIL 204 PE + + + + +D+WS GV+L+ I Sbjct: 222 PPESILYRKFT-TESDVWSFGVVLWEIF 248 >2QLU-A nrPDB Length = 314 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 58/209 (27%), Positives = 95/209 (45%), Gaps = 34/209 (16%) Query: 35 DNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTG- 93 D VA+KI L+++ Q +REI ++H N+++ S + + L +T Sbjct: 39 DFVAVKIFP----LQDKQSWQSEREIFSTPGMKHENLLQFIAAEKRGSNLEVELWLITAF 94 Query: 94 ---GELFDRIVHKGRL---------EESESRKYFQQLVDAVAHCHCKG----VYHRDLKP 137 G L D + KG + E+ SR L + V C +G + HRD K Sbjct: 95 HDKGSLTDYL--KGNIITWNELCHVAETMSRG-LSYLHEDVPWCRGEGHKPSIAHRDFKS 151 Query: 138 ENLLLDTNGNLKVSDFGLSALPQEGVELLRT--TCGTPNYVAPEVLSGQ-GYDGSA---A 191 +N+LL ++ ++DFGL+ + G T GT Y+APEVL G + A Sbjct: 152 KNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRI 211 Query: 192 DIWSCGVILFVIL----AGYLPFSETDLP 216 D+++ G++L+ ++ A P E LP Sbjct: 212 DMYAMGLVLWELVSRCKAADGPVDEYMLP 240 >4M69-B nrPDB Length = 283 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 42/166 (25%), Positives = 71/166 (42%), Gaps = 11/166 (6%) Query: 59 EISIMKIVRHPNIVRLYEVL----ASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKY 114 EI MK PNI+R++ + P + IV+E+ G L + + + L S Sbjct: 58 EIKTMKKFDSPNILRIFGICIDQTVKPPEFSIVMEYCELGTLRELLDREKDLTMSVRSLL 117 Query: 115 FQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTT----C 170 + + H HR++ + L+ +K++ F LS ++T Sbjct: 118 VLRAARGLYRLHHSETLHRNISSSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERS 177 Query: 171 GTPNYVAPEVLSGQG--YDGSAADIWSCGVILFVILAGYLPFSETD 214 + YV+PE L YD A+I+S G++L+ I G +PF D Sbjct: 178 SSTIYVSPERLKNPFCLYD-IKAEIYSFGIVLWEIATGKIPFEGCD 222 >4WUA-A nrPDB Length = 401 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 61/258 (23%), Positives = 101/258 (39%), Gaps = 65/258 (25%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 G+Y V R +G G F+ V + + VA+K++ + +D EI ++K VR+ Sbjct: 41 GRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALD----EIRLLKSVRN 96 Query: 69 -----PN---IVRLYE--VLASPSKIYIVLEF-VTGGELFDRIVHKGR--LEESESRKYF 115 PN +V+L + ++ + +I + F V G L I+ L +K Sbjct: 97 SDPNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKII 156 Query: 116 QQLVDAVAHCHCKG-VYHRDLKPENLLLDTN----------------------------- 145 QQ++ + + H K + H D+KPEN+LL N Sbjct: 157 QQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVST 216 Query: 146 GNLKVSDFGLSALPQEGVELLRTTCG-----------------TPNYVAPEVLSGQGYDG 188 +F ++ L + E L+ T Y + EVL G GY+ Sbjct: 217 APATAGNFLVNPLEPKNAEKLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYN- 275 Query: 189 SAADIWSCGVILFVILAG 206 + ADIWS + F + G Sbjct: 276 TPADIWSTACMAFELATG 293 >4BTF-A nrPDB Length = 469 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 42/166 (25%), Positives = 71/166 (42%), Gaps = 11/166 (6%) Query: 59 EISIMKIVRHPNIVRLYEVL----ASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKY 114 EI MK PNI+R++ + P + IV+E+ G L + + + L S Sbjct: 244 EIKTMKKFDSPNILRIFGICIDQTVKPPEFSIVMEYCELGTLRELLDREKDLTMSVRSLL 303 Query: 115 FQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTT----C 170 + + H HR++ + L+ +K++ F LS ++T Sbjct: 304 VLRAARGLYRLHHSETLHRNISSSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERS 363 Query: 171 GTPNYVAPEVLSGQG--YDGSAADIWSCGVILFVILAGYLPFSETD 214 + YV+PE L YD A+I+S G++L+ I G +PF D Sbjct: 364 SSTIYVSPERLKNPFCLYD-IKAEIYSFGIVLWEIATGKIPFEGCD 408 >5X1R-A nrPDB Length = 302 Score = 45.8 bits (107), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 46/229 (20%), Positives = 90/229 (39%), Gaps = 31/229 (13%) Query: 7 RVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNR--------------- 51 R ++E+ IGEG F V A + +AIK +++ K Sbjct: 19 RFNEFEIQEAIGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAKRNDDLSIGLRGERFGKT 78 Query: 52 ---MVDQIKREISIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFD-RIVHKGRLE 107 ++ +E ++ HP ++ + Y+ +F +G L + + +++ Sbjct: 79 FQAGLNSFIQEARLLARFSHPGLLHVLRFWEENGTAYMGTQFYSGTTLKNLQAQQPEKID 138 Query: 108 ESESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFG-----LSALPQEG 162 E+ R+ L A+ H +G HRD+ +N+ + + + DFG + L E Sbjct: 139 EAWIRRLLPPLFSAINTIHQEGYLHRDISLDNIQIQESQLPVLLDFGSARKEIGNLSDET 198 Query: 163 VELLRTTCGTPNYVAPEVLS--GQGYDGSAADIWSCGVILFVILAGYLP 209 +L+ P + E + G G DI++ G +L ++ G P Sbjct: 199 EIVLK-----PGFAPIEQYTENSDGEQGPWTDIYALGAVLHTLIVGSPP 242 >4LRM-A nrPDB Length = 334 Score = 45.8 bits (107), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 59/265 (22%), Positives = 112/265 (42%), Gaps = 19/265 (7%) Query: 15 RTIGEGTFAKVKFARNTDTGDNVAIKIMAKST--ILKNRMVDQIKREISIMKIVRHP--- 69 + +G G F V G+ V I + K + +I E +M V +P Sbjct: 25 KVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNP 84 Query: 70 NIVRLYEVLASPSKIYIVLEFVTGGELFDRI-VHKGRLEESESRKYFQQLVDAVAHCHCK 128 ++ RL + + S + ++ + + G L D + HK + + Q+ + + + Sbjct: 85 HVCRLLGICLT-STVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDR 143 Query: 129 GVYHRDLKPENLLLDTNGNLKVSDFGLSA-LPQEGVELLRTTCGTP-NYVAPEVLSGQGY 186 + HRDL N+L+ T ++K++DFGL+ L E E P ++A E + + Y Sbjct: 144 RLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIY 203 Query: 187 DGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAAE-FSCPPWFSAEVKFLIHRI 244 +D+WS GV ++ ++ G P+ + + E PP + +V ++ + Sbjct: 204 T-HQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKC 262 Query: 245 L----DPNPKTR---IQIQGIKKDP 262 D PK R I+ + +DP Sbjct: 263 WMIDADSRPKFRELIIEFSKMARDP 287 >5CLR-A nrPDB Length = 451 Score = 45.8 bits (107), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 32/109 (29%), Positives = 55/109 (50%), Gaps = 13/109 (11%) Query: 85 YIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLV-------DAVAHCHCKGVYHRDLKP 137 YI+ F+ G D +K L + + K+F +++ V H G+ HRDLKP Sbjct: 148 YILTTFIKG---IDLSRYKNALPLNVNLKHFWEVLGIMISVCHQVKQFHELGLIHRDLKP 204 Query: 138 ENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGY 186 N++LD + + DFG S+ +E + GT +Y+APE+ + + + Sbjct: 205 GNIMLDADMQCHLVDFGSSSSDKEPKP---ASWGTASYLAPELNAQEDF 250 >4XHL-A nrPDB Length = 394 Score = 45.4 bits (106), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 55/233 (23%), Positives = 91/233 (39%), Gaps = 50/233 (21%) Query: 7 RVG-KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKI 65 RVG K+ +GR IG G+F + N +G+ VAI++ + + Sbjct: 4 RVGRKFRIGRKIGSGSFGDIYHGTNLISGEEVAIRLESIRS------------------- 44 Query: 66 VRHPNI---VRLYEVLASPSKIYIVLEFVTGGELFDRIVH------KGRLEESESRKYFQ 116 RHP + R+Y L+ I + F GE ++ + R F+ Sbjct: 45 -RHPQLDYESRVYRYLSGGVGIPFIRWFGREGEYNAMVIDLLGPSLEDLFNYCHRRFSFK 103 Query: 117 -------QLVDAVAHCHCKGVYHRDLKPENLLLDT---NGNLKVSDFGLSALPQE----- 161 Q+ + + H + HRD+KP+N L+ + V DFGLS ++ Sbjct: 104 TVIMLALQMFCRIQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHR 163 Query: 162 --GVELLRTTCGTPNYVAPEVLSGQGYDGS-AADIWSCGVILFVILAGYLPFS 211 ++ GT Y + V + G + S D+ S G +L G LP+ Sbjct: 164 HIPYRENKSLTGTARYAS--VNTHLGIEQSRRDDLESLGYVLIYFCKGSLPWQ 214 >4XHH-A nrPDB Length = 403 Score = 45.1 bits (105), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 57/232 (24%), Positives = 95/232 (40%), Gaps = 50/232 (21%) Query: 7 RVG-KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKI 65 RVG K+ +GR IG G+F + N +G+ VAI++ + + Sbjct: 4 RVGRKFRIGRKIGSGSFGDIYHGTNLISGEEVAIRLESIRS------------------- 44 Query: 66 VRHPNI---VRLYEVLASPSKIYIVLEFVTGGELFDRIVH--KGRLEE--SESRKYFQ-- 116 RHP + R+Y+ L+ I + F GE ++ LE+ + + F Sbjct: 45 -RHPQLDYESRVYKYLSGGVGIPFIRWFGREGEYNAMVIDLLGPSLEDLFNYCHRKFSFK 103 Query: 117 -------QLVDAVAHCHCKGVYHRDLKPENLLLDT---NGNLKVSDFGLSALPQE----- 161 Q++ V + H + HRD+KP+N L+ + V DFGLS ++ Sbjct: 104 TVIMLALQMICRVQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHR 163 Query: 162 --GVELLRTTCGTPNYVAPEVLSGQGYDGS-AADIWSCGVILFVILAGYLPF 210 ++ GT Y + V + G + S D+ S G +L G LP+ Sbjct: 164 HIPYRENKSLTGTARYAS--VNTHLGIEQSRRDDLESLGYMLIYFCKGSLPW 213 >3SOC-A nrPDB Length = 322 Score = 45.1 bits (105), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 43/162 (26%), Positives = 74/162 (45%), Gaps = 19/162 (11%) Query: 37 VAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTG--- 93 VA+KI ++++ Q + E+ + ++H NI++ + + + L +T Sbjct: 50 VAVKIFP----IQDKQSWQNEYEVYSLPGMKHENILQFIGAEKRGTSVDVDLWLITAFHE 105 Query: 94 -GELFD----RIVHKGRL---EESESR--KYFQQLVDAVAHCHCKGVYHRDLKPENLLLD 143 G L D +V L E+ +R Y + + + H + HRD+K +N+LL Sbjct: 106 KGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLK 165 Query: 144 TNGNLKVSDFGLSALPQEGVELLRT--TCGTPNYVAPEVLSG 183 N ++DFGL+ + G T GT Y+APEVL G Sbjct: 166 NNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEG 207 >3G2F-A nrPDB Length = 336 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 55/197 (27%), Positives = 85/197 (43%), Gaps = 35/197 (17%) Query: 37 VAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLY----EVLASPSKIYI-VLEFV 91 VA+K+ + NR ++ I + ++ H NI R V A Y+ V+E+ Sbjct: 39 VAVKVFS----FANRQNFINEKNIYRVPLMEHDNIARFIVGDERVTADGRMEYLLVMEYY 94 Query: 92 TGGELFDRI-------VHKGRLEESESR--KYFQQLVDAVAHCHCKGVYHRDLKPENLLL 142 G L + V RL S +R Y + H + + HRDL N+L+ Sbjct: 95 PNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRGDH-YKPAISHRDLNSRNVLV 153 Query: 143 DTNGNLKVSDFGLSALPQEGVELLR---------TTCGTPNYVAPEVLSG--QGYDGSAA 191 +G +SDFGLS + G L+R + GT Y+APEVL G D +A Sbjct: 154 KNDGTCVISDFGLS-MRLTGNRLVRPGEEDNAAISEVGTIRYMAPEVLEGAVNLRDCESA 212 Query: 192 ----DIWSCGVILFVIL 204 D+++ G+I + I Sbjct: 213 LKQVDMYALGLIYWEIF 229 >3HNG-A nrPDB Length = 360 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 36/127 (28%), Positives = 61/127 (48%), Gaps = 11/127 (8%) Query: 114 YFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRT--TCG 171 Y Q+ + + HRDL N+LL N +K+ DFGL+ + + +R T Sbjct: 204 YSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKGDTRL 263 Query: 172 TPNYVAPEVLSGQGYDGSAADIWSCGVILFVILA-GYLPFS----ETDLPGLYR---KIN 223 ++APE + + Y + +D+WS GV+L+ I + G P+ + D R ++ Sbjct: 264 PLKWMAPESIFDKIY-STKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMRMR 322 Query: 224 AAEFSCP 230 A E+S P Sbjct: 323 APEYSTP 329 >2CHL-A nrPDB Length = 351 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 58/238 (24%), Positives = 101/238 (42%), Gaps = 26/238 (10%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 + VG+ IG G F +++ +N T + VAIK+ +K+R Q+ E K + + Sbjct: 32 FRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEP----MKSR-APQLHLEYRFYKQLGSGD 86 Query: 71 -IVRLYEVLASPSKIYIVLEFVTGG--ELFDRIVHKGRLEESESRKYFQQLVDAVAHCHC 127 I ++Y +VLE + +LFD L+ QL+ + + H Sbjct: 87 GIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAI--QLISRMEYVHS 144 Query: 128 KGVYHRDLKPENLLLDTNGN-----LKVSDFGLSAL---PQEGVEL----LRTTCGTPNY 175 K + +RD+KPEN L+ GN + + DF L+ P+ + ++ GT Y Sbjct: 145 KNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARY 204 Query: 176 VAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGL---YRKINAAEFSCP 230 ++ G+ D+ + G + L G LP+ L Y+KI + + P Sbjct: 205 MSINTHLGKE-QSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATP 261 >5USZ-A nrPDB Length = 289 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 71/271 (26%), Positives = 114/271 (42%), Gaps = 41/271 (15%) Query: 16 TIGEGTFAKVKFARNTDTGD-------NVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 ++G+GTF K+ + GD V +K++ K+ + S+M + H Sbjct: 15 SLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKA---HRNYSESFFEAASMMSKLSH 71 Query: 69 PNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGR-----LEESESRKYFQQLVDAVA 123 ++V Y V + +V EFV G L D + K + L + E K QL A+ Sbjct: 72 KHLVLNYGVCVCGDENILVQEFVKFGSL-DTYLKKNKNCINILWKLEVAK---QLAAAMH 127 Query: 124 HCHCKGVYHRDLKPENLLL-----DTNGN---LKVSDFGLS--ALPQEGVELLRTTCGTP 173 + H ++ +N+LL GN +K+SD G+S LP++ +L+ Sbjct: 128 FLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKD---ILQERIP-- 182 Query: 174 NYVAPEVLSGQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAAE--FSCP 230 +V PE + A D WS G L+ I + G P S D RK+ E P Sbjct: 183 -WVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALD---SQRKLQFYEDRHQLP 238 Query: 231 PWFSAEVKFLIHRILDPNPKTRIQIQGIKKD 261 +AE+ LI+ +D P R + I +D Sbjct: 239 APKAAELANLINNCMDYEPDHRPSFRAIIRD 269 >4NT4-A nrPDB Length = 312 Score = 42.7 bits (99), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 56/247 (22%), Positives = 106/247 (42%), Gaps = 38/247 (15%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIV-RHP 69 + VG+ IG G F +++ +N ++VAIK+ + Q+ E K++ H Sbjct: 14 FRVGKKIGCGNFGELRLGKNLYNNEHVAIKMEPMKS-----KAPQLHLEYRFYKLLGSHA 68 Query: 70 N-----IVRLYEVLASPSKI-YIVLEFV--TGGELFDRIVHKGRLEESESRKYFQQLVDA 121 + I R+Y + + +VLE + + +LF+ K L+ +QL+ Sbjct: 69 DNAPDGIPRIYHLGTCGGRYNAMVLELLGLSLEDLFNICARKFSLKTV--LMIAKQLLHR 126 Query: 122 VAHCHCKGVYHRDLKPENLLLDTNGN-----LKVSDFGLSALPQEGVEL----------L 166 + + H + + +RD+KPEN L+ + + DFGL+ +E ++L Sbjct: 127 IEYVHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLA---KEYIDLDTNRHIPYREH 183 Query: 167 RTTCGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGL---YRKIN 223 ++ GT Y++ G+ D+ + G + L G LP+ L Y+KI Sbjct: 184 KSLTGTARYMSINTHMGRE-QSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIG 242 Query: 224 AAEFSCP 230 + + P Sbjct: 243 DTKRATP 249 >2CMW-A nrPDB Length = 310 Score = 42.7 bits (99), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 59/237 (24%), Positives = 100/237 (42%), Gaps = 27/237 (11%) Query: 13 VGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN-- 70 VG+ IG G F +++ +N T + VAIK+ +K+R Q+ E K + Sbjct: 4 VGKKIGCGNFGELRLGKNLYTNEYVAIKLEP----IKSR-APQLHLEYRFYKQLGSAGEG 58 Query: 71 IVRLYEVLASPSKIYIVLEFVTGG--ELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCK 128 + ++Y +VLE + +LFD L+ QL+ + + H K Sbjct: 59 LPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAI--QLLSRMEYVHSK 116 Query: 129 GVYHRDLKPENLLLDTNGNLK-----VSDFGLSAL---PQEGVEL----LRTTCGTPNYV 176 + +RD+KPEN L+ GN K + DFGL+ P+ + ++ GT Y+ Sbjct: 117 NLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYM 176 Query: 177 APEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGL---YRKINAAEFSCP 230 + G+ D+ + G + L G LP+ L Y+KI + + P Sbjct: 177 SINTHLGKE-QSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRNTP 232 >2C47-A nrPDB Length = 313 Score = 41.6 bits (96), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 58/240 (24%), Positives = 102/240 (42%), Gaps = 30/240 (12%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMA-KSTILKNRMVDQIKREISIMKIVRHP 69 + VG+ IG G F +++ +N T + VAIK+ KS + + + +++S + V P Sbjct: 6 FRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLSATEGV--P 63 Query: 70 NIVRLYEVLASPSKIY--IVLEFVTGG--ELFDRIVHKGRLEESESRKYFQQLVDAVAHC 125 + P Y +VLE + +LFD L+ QL+ + + Sbjct: 64 QVYYF-----GPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAI--QLITRMEYV 116 Query: 126 HCKGVYHRDLKPENLLLDTNGN-----LKVSDFGLSAL---PQEGVEL----LRTTCGTP 173 H K + +RD+KPEN L+ G + + DFGL+ P+ + ++ GT Sbjct: 117 HTKSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTA 176 Query: 174 NYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGL---YRKINAAEFSCP 230 Y++ G+ D+ + G + L G LP+ L Y+KI + + P Sbjct: 177 RYMSINTHLGKE-QSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATP 235 >4OAU-C nrPDB Length = 699 Score = 41.6 bits (96), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 46/216 (21%), Positives = 87/216 (40%), Gaps = 39/216 (18%) Query: 57 KREISIMKIVR-HPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYF 115 +RE+S ++ R + ++V Y + +++ + VH+G E+E ++ Sbjct: 382 QREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFA 441 Query: 116 QQLVDAV------AHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTT 169 + ++ ++ H C G H+DL+P+N+L+D+ ++DF S Sbjct: 442 RNVLSSIFKAVQELHLSC-GYTHQDLQPQNILIDSKKAAHLADFDKSI----------KW 490 Query: 170 CGTPNYVAPEVLSGQGYDGSAADIWSCG-VILFVILAGYLPFSETDLPGLYRKINAAEFS 228 G P V D+ G ++L+V+ G + F + L + N Sbjct: 491 AGDPQEV-------------KRDLEDLGRLVLYVVKKGSISFED-----LKAQSNEEVVQ 532 Query: 229 CPPWFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWF 264 P E K LIHR+ P R + + P+F Sbjct: 533 LSP--DEETKDLIHRLFHPGEHVRDCLSDLLGHPFF 566 >4O1O-A nrPDB Length = 717 Score = 41.6 bits (96), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 31/108 (28%), Positives = 54/108 (50%), Gaps = 11/108 (10%) Query: 57 KREISIMKIVR-HPNIVRLYEVLASPSKIYIVL---EFVTGGELFDRIVHKGRL---EES 109 ++E+S ++ R + N+V Y + S +++ L E+ L + H+G EE Sbjct: 385 QQEVSCLQSSRANDNVVTFYGSESDGSCLHVCLALCEYTLQEHLAN---HRGDAVPNEED 441 Query: 110 ES-RKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLS 156 ES R L A+ H G H+DL+P+N+L+D+ ++DF S Sbjct: 442 ESARNILSSLFKAIGELHRSGYSHQDLQPQNILIDSKNGTFLADFDKS 489 >2X7G-A nrPDB Length = 389 Score = 41.2 bits (95), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 66/270 (24%), Positives = 106/270 (39%), Gaps = 72/270 (26%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 G+Y V R +G G F+ V + VA+K++ + +D+IK ++K VR Sbjct: 31 GRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIK----LLKCVRE 86 Query: 69 -----PN---IVRLYE--VLASPSKIYIVLEF-VTGGELFDRIV---HKG---RLEESES 111 PN +V+L + ++ + I++ + F V G L I+ ++G R +S Sbjct: 87 SDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSII 146 Query: 112 RKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTN-------------------------- 145 R+ Q L H CK + H D+KPEN+L+ + Sbjct: 147 RQVLQGL--DYLHSKCK-IIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSA 203 Query: 146 -GNLKVSDFGLSALPQEGVELLRTTCG-----------------TPNYVAPEVLSGQGYD 187 +D ++ L + +R T Y + EVL G GY Sbjct: 204 VSTAPAADLLVNPLDPRNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGY- 262 Query: 188 GSAADIWSCGVILFVILAG-YL--PFSETD 214 + ADIWS + F + G YL P S D Sbjct: 263 STPADIWSTACMAFELATGDYLFEPHSGED 292 >5VC6-A nrPDB Length = 289 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 64/278 (23%), Positives = 108/278 (38%), Gaps = 37/278 (13%) Query: 2 TKKMRRVGKYEVGRTIGEGTFAKV-KFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREI 60 + K R ++ IG G F V K + D G AIK +K + + RE+ Sbjct: 4 SMKSRYTTEFHELEKIGSGEFGSVFKCVKRLD-GCIYAIK-RSKKPLAGSVDEQNALREV 61 Query: 61 SIMKIV-RHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRL----EESESRKYF 115 ++ +H ++VR + A + I E+ GG L D I R+ +E+E + Sbjct: 62 YAHAVLGQHSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLL 121 Query: 116 QQLVDAVAHCHCKGVYHRDLKPENLLL----------------DTNGN---LKVSDFG-L 155 Q+ + + H + H D+KP N+ + D N K+ D G + Sbjct: 122 LQVGRGLRYIHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHV 181 Query: 156 SALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDL 215 + + VE G ++A EVL ADI++ + + V AG P Sbjct: 182 TRISSPQVEE-----GDSRFLANEVLQENYTHLPKADIFALALTV-VCAAGAEPLPRNG- 234 Query: 216 PGLYRKINAAEFS-CPPWFSAEVKFLIHRILDPNPKTR 252 + +I P S E L+ ++ P+P+ R Sbjct: 235 -DQWHEIRQGRLPRIPQVLSQEFTELLKVMIHPDPERR 271 >4RT7-A nrPDB Length = 415 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 33/129 (25%), Positives = 62/129 (48%), Gaps = 5/129 (3%) Query: 117 QLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLS-ALPQEGVELLRTTCGTP-N 174 Q+ + K HRDL N+L+ +K+ DFGL+ + + ++R P Sbjct: 251 QVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVK 310 Query: 175 YVAPEVLSGQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAAEFSC-PPW 232 ++APE L +G +D+WS G++L+ I + G P+ + + K+ F P+ Sbjct: 311 WMAPESLF-EGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPF 369 Query: 233 FSAEVKFLI 241 ++ E ++I Sbjct: 370 YATEEIYII 378 Score = 37.0 bits (84), Expect = 0.015, Method: Compositional matrix adjust. Identities = 26/98 (26%), Positives = 44/98 (44%), Gaps = 8/98 (8%) Query: 12 EVGRTIGEGTFAKVKFA-----RNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIM-KI 65 E G+ +G G F KV A T VA+K++ + R + + E+ +M ++ Sbjct: 68 EFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSER--EALMSELKMMTQL 125 Query: 66 VRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHK 103 H NIV L IY++ E+ G+L + + K Sbjct: 126 GSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSK 163 >4MWI-A nrPDB Length = 294 Score = 39.3 bits (90), Expect = 0.003, Method: Compositional matrix adjust. Identities = 60/257 (23%), Positives = 105/257 (40%), Gaps = 52/257 (20%) Query: 37 VAIKIMAKSTILKNRMVDQ-IKREISIMKIVRHPNIVRLYEVL----ASPSKIYIVLEFV 91 VAIK+ K +V Q +EI MK PNI+R++ + +P + IV+E+ Sbjct: 50 VAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYC 109 Query: 92 TGG---ELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVY----------HRDLKPE 138 G EL DR E+ + LV A +G+Y H ++ Sbjct: 110 ELGTLRELLDR-------EKDLTLGKRMVLVLGAA----RGLYRLHHSEAPELHGKIRSS 158 Query: 139 NLLLDTNGNLKVSDFGLS--------ALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSA 190 N L+ +K++ F L +E + +++T Y++P+ L Y Sbjct: 159 NFLVTQGYQVKLAGFELRKTQTSMSLGTTREKTDRVKSTA----YLSPQELEDVFYQYDV 214 Query: 191 -ADIWSCGVILFVILAGYLPFSETD------LPGLYRKINAAEFSCPPWFSAEVKFLIHR 243 ++I+S G++L+ I G +PF + L + R+ CP +E++ +I Sbjct: 215 KSEIYSFGIVLWEIATGDIPFQGCNSEKIRKLVAVKRQQEPLGEDCP----SELREIIDE 270 Query: 244 ILDPNPKTRIQIQGIKK 260 +P R + I K Sbjct: 271 CRAHDPSVRPSVDEILK 287 >1CSN-A nrPDB Length = 298 Score = 38.9 bits (89), Expect = 0.004, Method: Compositional matrix adjust. Identities = 52/215 (24%), Positives = 87/215 (40%), Gaps = 21/215 (9%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH-P 69 Y+VGR IGEG+F + N VAIK + + Q++ E K++ Sbjct: 12 YKVGRRIGEGSFGVIFEGTNLLNNQQVAIKFEPRRSD-----APQLRDEYRTYKLLAGCT 66 Query: 70 NIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGR-LEESESRKYFQQLVDAVAHCHCK 128 I +Y +V++ + G L D + GR +Q++ V H K Sbjct: 67 GIPNVYYFGQEGLHNVLVIDLL-GPSLEDLLDLCGRKFSVKTVAMAAKQMLARVQSIHEK 125 Query: 129 GVYHRDLKPENLLL----DTNGNL-KVSDFGLSALPQEGVELL-------RTTCGTPNYV 176 + +RD+KP+N L+ N N+ V DFG+ ++ V + GT Y+ Sbjct: 126 SLVYRDIKPDNFLIGRPNSKNANMIYVVDFGMVKFYRDPVTKQHIPYREKKNLSGTARYM 185 Query: 177 APEVLSGQGYDGSAADIWSCGVILFVILAGYLPFS 211 + G+ D+ + G + L G LP+ Sbjct: 186 SINTHLGRE-QSRRDDLEALGHVFMYFLRGSLPWQ 219 >3VHK-A nrPDB Length = 368 Score = 38.5 bits (88), Expect = 0.006, Method: Compositional matrix adjust. Identities = 27/82 (32%), Positives = 44/82 (53%), Gaps = 4/82 (4%) Query: 132 HRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRT-TCGTP-NYVAPEVLSGQGYDGS 189 HRDL N+LL +K+ DFGL+ + + +R P ++APE + + Y Sbjct: 223 HRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYT-I 281 Query: 190 AADIWSCGVILFVILA-GYLPF 210 +D+WS GV+L+ I + G P+ Sbjct: 282 QSDVWSFGVLLWEIFSLGASPY 303 >6EQI-C nrPDB Length = 433 Score = 38.1 bits (87), Expect = 0.008, Method: Compositional matrix adjust. Identities = 32/127 (25%), Positives = 57/127 (44%), Gaps = 28/127 (22%) Query: 120 DAVAHCHCKGVYHRDLKPENLLLD-TNGN----LKVSDFGLSALPQEGVELL------RT 168 +AVAH + + HRDLK +N+L+D + G+ + ++DFG ++ ++ + Sbjct: 178 EAVAHMNIHNISHRDLKSDNILVDLSEGDAYPTIVITDFGCCLCDKQNGLVIPYRSEDQD 237 Query: 169 TCGTPNYVAPEVLSGQ-----GYDGSAADIWSCGVILFVILAGYLPF------------S 211 G +APE+ + + + +D+W+ G I + I PF Sbjct: 238 KGGNRALMAPEIANAKPGTFSWLNYKKSDLWAVGAIAYEIFNIDNPFYDKTMKLLSKSYK 297 Query: 212 ETDLPGL 218 E DLP L Sbjct: 298 EEDLPEL 304 >4IX6-A nrPDB Length = 350 Score = 38.1 bits (87), Expect = 0.008, Method: Compositional matrix adjust. Identities = 20/50 (40%), Positives = 31/50 (62%), Gaps = 2/50 (4%) Query: 111 SRKYFQQLVDAVAHCHCKGVYHRDLKPENLLL--DTNGNLKVSDFGLSAL 158 ++K ++L+ ++A H GV HRD+KP NL+ G LK+ D G +AL Sbjct: 145 TKKAMRELLGSLARLHECGVVHRDVKPANLIAAEKDGGVLKLIDLGAAAL 194 >5VDK-A nrPDB Length = 297 Score = 37.7 bits (86), Expect = 0.009, Method: Compositional matrix adjust. Identities = 46/228 (20%), Positives = 80/228 (35%), Gaps = 37/228 (16%) Query: 67 RHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGR----LEESESRKYFQQLVDAV 122 HP++VR Y A + I E+ GG L I + EE + + Q+ + Sbjct: 73 HHPHVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQISLGL 132 Query: 123 AHCHCKGVYHRDLKPENL-----------------------LLDTNGNLKVSDFGLSALP 159 + H + H D+KP N+ L N K+ D G + Sbjct: 133 NYIHNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGDLGHAT-- 190 Query: 160 QEGVELLRTTCGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVIL-AGYLPFSETDLPGL 218 + + G ++A E+L ADI++ G+ + V A LP + Sbjct: 191 --SINKPKVEEGDSRFLANEILQEDYRHLPKADIFALGLTIAVAAGAESLPTN----GAA 244 Query: 219 YRKINAAEF-SCPPWFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFR 265 + I F P S L+ ++ P+ + R + ++ R Sbjct: 245 WHHIRKGNFPDVPQELSESFSSLLKNMIQPDAEQRPSAAALARNTVLR 292 >5C01-A nrPDB Length = 342 Score = 37.7 bits (86), Expect = 0.010, Method: Compositional matrix adjust. Identities = 58/219 (26%), Positives = 93/219 (42%), Gaps = 31/219 (14%) Query: 61 SIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYF--QQL 118 S+M V H ++ ++ V + +V E+V G L D + + R + K QQL Sbjct: 131 SLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPL-DVWLRRERGHVPMAWKMVVAQQL 189 Query: 119 VDAVAHCHCKGVYHRDLKPENLLL-------DTNGNLKVSD--FGLSALP-QEGVELLRT 168 A+++ K + H ++ N+LL T+ +K+SD GL AL +E VE + Sbjct: 190 ASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERI-- 247 Query: 169 TCGTPNYVAPEVLSGQGYD-GSAADIWSCGVILF-VILAGYLPF---SETDLPGLY-RKI 222 ++APE L G +A D W G L + G P S ++ Y R+ Sbjct: 248 -----PWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQH 302 Query: 223 NAAEFSCPPWFSAEVKFLIHRILDPNPKTRIQIQGIKKD 261 E SCP ++ L + L P R + I +D Sbjct: 303 RLPEPSCP-----QLATLTSQCLTYEPTQRPSFRTILRD 336 >4WOV-A nrPDB Length = 317 Score = 37.4 bits (85), Expect = 0.013, Method: Compositional matrix adjust. Identities = 59/219 (26%), Positives = 93/219 (42%), Gaps = 31/219 (14%) Query: 61 SIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYF--QQL 118 S+M V H ++ ++ V + +V E+V G L D + + R + K QQL Sbjct: 108 SLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPL-DVWLRRERGHVPMAWKMVVAQQL 166 Query: 119 VDAVAHCHCKGVYHRDLKPENLLL-------DTNGNLKVSD--FGLSALP-QEGVELLRT 168 A+++ K + H ++ N+LL T+ +K+SD GL AL +E VE + Sbjct: 167 ASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERI-- 224 Query: 169 TCGTPNYVAPEVLSGQGYDGSAA-DIWSCGVILF-VILAGYLPF---SETDLPGLY-RKI 222 ++APE L G S A D W G L + G P S ++ Y R+ Sbjct: 225 -----PWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQH 279 Query: 223 NAAEFSCPPWFSAEVKFLIHRILDPNPKTRIQIQGIKKD 261 E SCP ++ L + L P R + I +D Sbjct: 280 RLPEPSCP-----QLATLTSQCLTYEPTQRPSFRTILRD 313 >4AZW-A nrPDB Length = 471 Score = 36.6 bits (83), Expect = 0.026, Method: Compositional matrix adjust. Identities = 22/78 (28%), Positives = 42/78 (53%), Gaps = 4/78 (5%) Query: 85 YIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDT 144 ++V+E + G L D + EE + K L+ ++A KG +H D++P N+++D Sbjct: 318 WLVMEKLPGRLLSDMLAAG---EEIDREKILGSLLRSLAALEKKGFWHDDVRPWNVMVDA 374 Query: 145 NGNLKVSDFG-LSALPQE 161 + ++ DFG + PQ+ Sbjct: 375 RQHARLIDFGSIVTTPQD 392 >5J0A-A nrPDB Length = 300 Score = 36.2 bits (82), Expect = 0.029, Method: Compositional matrix adjust. Identities = 41/176 (23%), Positives = 78/176 (44%), Gaps = 17/176 (9%) Query: 46 TILKNRMVDQIKREISIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGR 105 ++ + R++D+ K I+K + HPNIV Y + + L GGE + + R Sbjct: 55 SVYQKRLMDEAK----ILKSLHHPNIVG-YRAFTEANDGSLCLAMEYGGEKSLNDLIEER 109 Query: 106 LEESESR-------KYFQQLVDAVAHCHC-KGVYHRDLKPENLLLDTN-GNLKVSDFGLS 156 + S+ K + + + H K + H D+K N+++ + +K+ D G+S Sbjct: 110 YKASQDPFPAAIILKVALNMARGLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVS 169 Query: 157 ALPQEGVELLRT-TC--GTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLP 209 E +E+ C GT + E + G ADI++ G+ L+ ++ +P Sbjct: 170 LPLDENMEVTDPEACYIGTEPWKPKEAVEENGVITDKADIFAFGLTLWEMMTLSIP 225 >5UI3-D nrPDB Length = 341 Score = 35.4 bits (80), Expect = 0.045, Method: Compositional matrix adjust. Identities = 40/135 (29%), Positives = 64/135 (47%), Gaps = 16/135 (11%) Query: 174 NYVAPEVLSGQGYDGSAADI-WSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPW 232 NY + V G D + D S G + G + + +PGL K+ S P Sbjct: 209 NYTSKGVNCWSGNDDESHDARHSNGAV------GVISVTSNVIPGLMHKL--MHGSPDPQ 260 Query: 233 FSAEVKFLIHRIL-DPNP---KTRIQIQGIKKDPWFRLNYVPI-RA-REEEEVNLDDIRA 286 +A++K L+ + +PNP T + + G+ + P FRL YVP+ RA RE+ V L+ ++ Sbjct: 261 LNADLKELMAWMFCEPNPISLNTALAMCGLAR-PVFRLPYVPLSRAQREKGAVLLNKVQE 319 Query: 287 VFDGIEGSYVAENVE 301 G + V E+ E Sbjct: 320 HIPGCKSVRVMEDHE 334 >3Q60-A nrPDB Length = 371 Score = 35.4 bits (80), Expect = 0.049, Method: Compositional matrix adjust. Identities = 27/96 (28%), Positives = 44/96 (45%), Gaps = 6/96 (6%) Query: 117 QLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYV 176 QL+ A+ KG+ H P+NL + +G L + D +SAL + G P Sbjct: 202 QLIRLAANLQSKGLVHGHFTPDNLFIMPDGRLMLGD--VSALWKVGTR--GPASSVPVTY 257 Query: 177 AP-EVLSGQGYDGS-AADIWSCGVILFVILAGYLPF 210 AP E L+ + A + W G+ ++ + +LPF Sbjct: 258 APREFLNASTATFTHALNAWQLGLSIYRVWCLFLPF 293 >4K0V-A nrPDB Length = 529 Score = 35.4 bits (80), Expect = 0.049, Method: Compositional matrix adjust. Identities = 28/118 (23%), Positives = 44/118 (37%), Gaps = 4/118 (3%) Query: 19 EGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH--PNIVRLYE 76 + +F D GDNV I K ++K K I + RH P+I+ ++ Sbjct: 99 QASFLPATLTMTVDKGDNVNISF--KKVLIKEEDAVIYKNGSFIHSVPRHEVPDILEVHL 156 Query: 77 VLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRD 134 A P + GG LF + + E++K+ + C GV H D Sbjct: 157 PHAQPQDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGPECNHLCTACMNNGVCHED 214 >2GY7-B nrPDB Length = 423 Score = 35.4 bits (80), Expect = 0.051, Method: Compositional matrix adjust. Identities = 28/118 (23%), Positives = 44/118 (37%), Gaps = 4/118 (3%) Query: 19 EGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH--PNIVRLYE 76 + +F D GDNV I K ++K K I + RH P+I+ ++ Sbjct: 99 QASFLPATLTMTVDKGDNVNISF--KKVLIKEEDAVIYKNGSFIHSVPRHEVPDILEVHL 156 Query: 77 VLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRD 134 A P + GG LF + + E++K+ + C GV H D Sbjct: 157 PHAQPQDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGPECNHLCTACMNNGVCHED 214 >4AZV-A nrPDB Length = 569 Score = 35.4 bits (80), Expect = 0.052, Method: Compositional matrix adjust. Identities = 19/70 (27%), Positives = 38/70 (54%), Gaps = 3/70 (4%) Query: 85 YIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDT 144 ++V+E + G L D + EE + K L+ ++A +G +H D++P N+++D Sbjct: 318 WLVMEKLPGRLLSDMLAAG---EEIDREKILGSLLRSLAALEKQGFWHDDVRPWNVMVDA 374 Query: 145 NGNLKVSDFG 154 + ++ DFG Sbjct: 375 RQHARLIDFG 384 >2W1Z-A nrPDB Length = 368 Score = 33.5 bits (75), Expect = 0.21, Method: Compositional matrix adjust. Identities = 29/120 (24%), Positives = 51/120 (42%), Gaps = 15/120 (12%) Query: 100 IVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALP 159 +VH RL+ + QL+ A G+ H D + N+LLD G + ++ G L Sbjct: 188 LVHHARLQLT------LQLIRLAASLQHYGLVHADFQVRNILLDQRGGVFLT--GFEHLV 239 Query: 160 QEG---VELLRTTCGTPNYVAPEVLSGQGYDGSAA----DIWSCGVILFVILAGYLPFSE 212 ++G V + P A +L + + + D W+ G+ ++ I LP +E Sbjct: 240 RDGASAVSPIGRGFAPPETTAERMLPYRQHHPTLMTFPFDTWTLGLAIYWIWCADLPNTE 299 >3DZO-A nrPDB Length = 413 Score = 33.1 bits (74), Expect = 0.23, Method: Compositional matrix adjust. Identities = 30/117 (25%), Positives = 53/117 (45%), Gaps = 15/117 (12%) Query: 100 IVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALP 159 +VH RL+ + Q++ +A H G+ H L+P +++LD G + ++ G L Sbjct: 208 LVHHARLQLT------LQVIRLLASLHHYGLVHTYLRPVDIVLDQRGGVFLT--GFEHLV 259 Query: 160 QEG---VELLRTTCGTPNYVAPEVLS-GQGYD---GSAADIWSCGVILFVILAGYLP 209 ++G V + P A +L GQ + A D W+ G+ ++ I LP Sbjct: 260 RDGASAVSPIGRGFAPPETTAERMLPFGQHHPTLMTFAFDTWTLGLAIYWIWCADLP 316 >3BYV-A nrPDB Length = 377 Score = 32.7 bits (73), Expect = 0.32, Method: Compositional matrix adjust. Identities = 25/123 (20%), Positives = 57/123 (46%), Gaps = 20/123 (16%) Query: 100 IVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALP 159 +VH RL+ + Q++ +A H G+ H L+P +++LD G + ++ G L Sbjct: 203 LVHHARLQLT------LQVIRLLASLHHYGLVHTYLRPVDIVLDQRGGVFLT--GFEHLV 254 Query: 160 QEGVELLRTTCGTPNYVAPEVLSGQGYDGS----------AADIWSCGVILFVILAGYLP 209 ++G ++ + + + PE+ + + + D W+ G++++ I LP Sbjct: 255 RDGARVVSSV--SRGFEPPELEARRATISYHRDRRTLMTFSFDAWALGLVIYWIWCADLP 312 Query: 210 FSE 212 ++ Sbjct: 313 ITK 315 >4CI6-B nrPDB Length = 643 Score = 32.7 bits (73), Expect = 0.37, Method: Compositional matrix adjust. Identities = 42/188 (22%), Positives = 78/188 (41%), Gaps = 34/188 (18%) Query: 49 KNRMVDQIKREIS-------------IMKIV-RHPNIVRLYEVLASP--SKIY--IVLEF 90 K R+V +I+R I+ I K +HPN+ ++ + P ++ Y ++++ Sbjct: 68 KQRLVAKIERSIAEGHLFAELEAYKHIYKTAGKHPNLANVHGMAVVPYGNRYYYALLMDE 127 Query: 91 VTGGELFD---RIVHKGRLEESESRKYF-------QQLVDAVAHCHCKGVYHRDLKPENL 140 V G D + + + S Y+ +L+D H G+ H D+KP N+ Sbjct: 128 VDGWRCSDTLRSLADSWKQGKINSEAYWGTIKFIAHRLLDVTNHLAKAGIVHNDIKPGNV 187 Query: 141 LLD-TNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSAADIWSCGVI 199 + D +G V D GL + E + T ++ APE+ G +D++ Sbjct: 188 VFDRASGEPVVIDLGLHSRSGE-----QPKGFTESFKAPELGVGNLGASEKSDVFLVVST 242 Query: 200 LFVILAGY 207 L + G+ Sbjct: 243 LLHGIEGF 250 >2JMM-A nrPDB Length = 156 Score = 31.2 bits (69), Expect = 1.0, Method: Compositional matrix adjust. Identities = 14/35 (40%), Positives = 22/35 (62%) Query: 222 INAAEFSCPPWFSAEVKFLIHRILDPNPKTRIQIQ 256 I+AAE S P F+ V+++I R + P TR++ Q Sbjct: 97 ISAAEASVSPVFAGGVEYVIRRRITPEIATRLEYQ 131 >1SGF-G nrPDB Length = 237 Score = 29.3 bits (64), Expect = 3.2, Method: Compositional matrix adjust. Identities = 11/27 (40%), Positives = 17/27 (62%) Query: 197 GVILFVILAGYLPFSETDLPGLYRKIN 223 GV+ + G+ P E D+PG+Y K+N Sbjct: 197 GVLQGITSWGHTPCGEPDMPGVYTKLN 223 >6BHC-A nrPDB Length = 438 Score = 29.3 bits (64), Expect = 3.5, Method: Compositional matrix adjust. Identities = 25/88 (28%), Positives = 43/88 (48%), Gaps = 8/88 (9%) Query: 176 VAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLY-RKINAAEFSCPPW-- 232 +APE+++ Y D + G++++ +L PF E P L R+ A+ P+ Sbjct: 264 LAPEIITATQY--KKCDEFQTGILIYEMLHLPNPFDEN--PELKEREYTRADLPRIPFRS 319 Query: 233 -FSAEVKFLIHRILDPNPKTRIQIQGIK 259 +S ++ L +L+PNP RI I K Sbjct: 320 PYSRGLQQLASCLLNPNPSERILISDAK 347 >1TQY-A nrPDB Length = 424 Score = 28.9 bits (63), Expect = 4.5, Method: Compositional matrix adjust. Identities = 19/69 (27%), Positives = 32/69 (46%), Gaps = 6/69 (8%) Query: 233 FSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEVNLDDIRAVFDGIE 292 +A V L H ++ P R DP L+YVP+ ARE + ++ + + F G + Sbjct: 356 IAACVLALEHGVVPPTANLRTS------DPECDLDYVPLEARERKLRSVLTVGSGFGGFQ 409 Query: 293 GSYVAENVE 301 + V + E Sbjct: 410 SAMVLRDAE 418 >2Y4N-A nrPDB Length = 437 Score = 28.9 bits (63), Expect = 4.6, Method: Compositional matrix adjust. Identities = 25/83 (30%), Positives = 38/83 (45%), Gaps = 10/83 (12%) Query: 129 GVYHRDLKP----ENLLLDTNGNLKVS-DFGLSALPQEGVELLRTTCGTPNYVAPEVLSG 183 GV+ DLK T G+L+ S FG+ A+PQ+ + + + GT P V+ Sbjct: 53 GVHPDDLKTLADLSRFPFTTKGDLRDSYPFGMFAVPQDRISRIHASSGTTG--KPTVV-- 108 Query: 184 QGYDGSAADIWSCGVILFVILAG 206 GY + D W+ V + AG Sbjct: 109 -GYTAADIDTWANLVARSIRAAG 130 >5UV4-A nrPDB Length = 311 Score = 28.9 bits (63), Expect = 4.6, Method: Compositional matrix adjust. Identities = 41/167 (24%), Positives = 68/167 (40%), Gaps = 19/167 (11%) Query: 55 QIKREISIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKY 114 + REI + VRHPN+V L P + E + + D L E + R Sbjct: 67 EFSREIKKLGSVRHPNLVPLRGYYWGPKE----HERIMISDYADATSLSTYLSEFDERNL 122 Query: 115 -----FQQLVDAVAHCHC-------KGVYHRDLKPENLLL-DTNGNLKVSDFGLSALPQE 161 Q+L A+ C + + H ++K N+L+ ++ + V+D+ L L Sbjct: 123 PPLSAGQRLNIAIDIARCLDYLHNERVIPHGNIKSSNVLIQNSTPSALVTDYSLHRLMTP 182 Query: 162 -GVELLRTTCGTPNYVAPEVLS-GQGYDGSAADIWSCGVILFVILAG 206 G+ G Y PE S + +D+++ GVIL +L G Sbjct: 183 IGMAEQVLNAGALGYSPPEFSSTSKPCPSLKSDVYAFGVILLELLTG 229 >4A8J-B nrPDB Length = 270 Score = 28.9 bits (63), Expect = 4.9, Method: Compositional matrix adjust. Identities = 15/41 (36%), Positives = 23/41 (56%), Gaps = 4/41 (9%) Query: 111 SRKYFQQLVDAVAHCHCKGV--YHRDLKPEN--LLLDTNGN 147 S +Y + + +A HC V YH+D+K EN ++ D N N Sbjct: 113 STEYITRFLSEIASPHCTMVATYHKDIKDENRTVIPDWNNN 153 >5VE6-A nrPDB Length = 492 Score = 28.9 bits (63), Expect = 5.3, Method: Compositional matrix adjust. Identities = 18/43 (41%), Positives = 22/43 (51%), Gaps = 2/43 (4%) Query: 102 HKGRLEESESRKYFQ--QLVDAVAHCHCKGVYHRDLKPENLLL 142 H+ E E R F QL + + H G+ HRDL ENLLL Sbjct: 199 HQAEPEAYERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLL 241 >4EJS-B nrPDB Length = 242 Score = 28.9 bits (63), Expect = 5.3, Method: Compositional matrix adjust. Identities = 15/41 (36%), Positives = 23/41 (56%), Gaps = 4/41 (9%) Query: 111 SRKYFQQLVDAVAHCHCKGV--YHRDLKPEN--LLLDTNGN 147 S +Y + + +A HC V YH+D+K EN ++ D N N Sbjct: 117 STEYITRFLSEIASPHCTMVATYHKDIKDENRTVIPDWNNN 157 >1Y0Y-A nrPDB Length = 353 Score = 28.5 bits (62), Expect = 6.7, Method: Compositional matrix adjust. Identities = 22/64 (34%), Positives = 25/64 (39%), Gaps = 19/64 (29%) Query: 31 TDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYEVLASPSKIYIVLEF 90 T G AIKIM +S I HP IVR E LA +I LE Sbjct: 252 THLGKGTAIKIMDRSVIC-------------------HPTIVRWLEELAKKHEIPYQLEI 292 Query: 91 VTGG 94 + GG Sbjct: 293 LLGG 296 >6EWX-A nrPDB Length = 484 Score = 28.1 bits (61), Expect = 7.2, Method: Compositional matrix adjust. Identities = 18/43 (41%), Positives = 22/43 (51%), Gaps = 2/43 (4%) Query: 102 HKGRLEESESRKYFQ--QLVDAVAHCHCKGVYHRDLKPENLLL 142 H+ E E R F QL + + H G+ HRDL ENLLL Sbjct: 201 HRAEPEVYERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLL 243 >6G4J-A nrPDB Length = 315 Score = 28.1 bits (61), Expect = 8.1, Method: Compositional matrix adjust. Identities = 32/143 (22%), Positives = 58/143 (40%), Gaps = 25/143 (17%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 Y + + +G+G V A +D +VA+K+ S I E++++K Sbjct: 28 YTLRKQLGKGANGIVYLAETSD--GHVALKVSDDSL--------SITSEVNVLKSFSKAQ 77 Query: 71 IVRLYEVLASPSKIYI----------VLEFVTGGELFDRIVHKGRLEESESRKYFQ-QLV 119 V + YI +E++ G L + KG +E QL+ Sbjct: 78 SVTMGPSFFDTDDAYIPSANTKVSFYAMEYIKGPLLLKYVSDKG----AEWIPVLMIQLL 133 Query: 120 DAVAHCHCKGVYHRDLKPENLLL 142 +++ H +G DLKP+NL++ Sbjct: 134 SSLSVLHQQGWIFGDLKPDNLIV 156 >6H45-A nrPDB Length = 392 Score = 27.7 bits (60), Expect = 9.8, Method: Compositional matrix adjust. Identities = 16/43 (37%), Positives = 21/43 (48%) Query: 137 PENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPE 179 P NLL D+ G VS LS + +EGV G ++PE Sbjct: 88 PHNLLTDSGGFQMVSLVSLSEVTEEGVRFRSPYDGNETLLSPE 130 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 4D28-A nrPDB 681 0.0 4CZT-A nrPDB 554 e-158 3H4J-B nrPDB 358 4e-99 5JN2-A nrPDB 343 1e-94 3NCG-A nrPDB 343 1e-94 3LIJ-A nrPDB 337 6e-93 4CFF-A nrPDB 336 2e-92 4REW-A nrPDB 335 2e-92 5EZV-A nrPDB 332 1e-91 3MN3-A nrPDB 330 7e-91 4RED-A nrPDB 330 7e-91 4CFH-A nrPDB 330 8e-91 5KZ7-A nrPDB 328 3e-90 5ES1-A nrPDB 327 4e-90 2QNJ-A nrPDB 326 1e-89 2YZA-A nrPDB 325 3e-89 3HZT-A nrPDB 323 7e-89 4YZB-A nrPDB 318 3e-87 4CQG-A nrPDB 316 1e-86 3Q5I-A nrPDB 313 1e-85 4RGJ-A nrPDB 313 1e-85 4D2V-A nrPDB 313 1e-85 5WAX-A nrPDB 310 8e-85 2HAK-A nrPDB 309 1e-84 6C9D-A nrPDB 308 2e-84 5F9E-A nrPDB 306 1e-83 2VN9-A nrPDB 306 2e-83 3MA6-A nrPDB 305 3e-83 4MVF-A nrPDB 305 3e-83 3TXO-A nrPDB 305 3e-83 5FG8-A nrPDB 305 3e-83 5YKS-A nrPDB 304 4e-83 2V7O-A nrPDB 304 6e-83 2JDO-A nrPDB 303 1e-82 4YNZ-A nrPDB 303 1e-82 4B6L-A nrPDB 303 1e-82 5IG1-A nrPDB 303 1e-82 3DFA-A nrPDB 302 2e-82 3DXN-A nrPDB 302 2e-82 1FOT-A nrPDB 302 2e-82 4L42-A nrPDB 301 3e-82 5U6Y-A nrPDB 300 8e-82 5N23-A nrPDB 300 8e-82 2VZ6-A nrPDB 300 8e-82 3BHH-A nrPDB 300 9e-82 5X3F-B nrPDB 300 9e-82 3ZUT-A nrPDB 300 9e-82 4UZD-A nrPDB 299 1e-81 2BDW-A nrPDB 299 1e-81 3UC3-A nrPDB 299 1e-81 4RLP-A nrPDB 299 1e-81 3D2K-A nrPDB 299 2e-81 5D9K-A nrPDB 299 2e-81 4WB7-A nrPDB 298 2e-81 3DB8-A nrPDB 297 6e-81 4I6B-A nrPDB 297 6e-81 3MV5-A nrPDB 297 6e-81 4FG9-A nrPDB 297 6e-81 5KCV-A nrPDB 297 7e-81 2Z7Q-A nrPDB 297 8e-81 2JC6-A nrPDB 296 1e-80 3UDB-A nrPDB 296 2e-80 3KK8-A nrPDB 295 2e-80 3SOA-A nrPDB 295 2e-80 4JXF-A nrPDB 294 8e-80 4RA4-A nrPDB 293 8e-80 3HDN-A nrPDB 293 1e-79 2JAM-A nrPDB 290 9e-79 4NIF-A nrPDB 289 2e-78 4B8L-A nrPDB 287 5e-78 2OU7-A nrPDB 287 5e-78 6E9W-A nrPDB 285 2e-77 4J52-A nrPDB 285 2e-77 6CMJ-A nrPDB 285 2e-77 3PFQ-A nrPDB 285 3e-77 3F3Z-A nrPDB 285 3e-77 2BPM-A nrPDB 285 3e-77 3COM-A nrPDB 284 5e-77 6ED6-A nrPDB 283 9e-77 5XZW-A nrPDB 282 1e-76 2I0E-A nrPDB 282 2e-76 2W4O-A nrPDB 281 3e-76 2YAB-A nrPDB 281 5e-76 4JG6-A nrPDB 280 9e-76 3TAC-A nrPDB 279 2e-75 2J90-A nrPDB 278 4e-75 6FDY-U nrPDB 277 9e-75 3ORZ-A nrPDB 276 1e-74 4LG4-A nrPDB 276 1e-74 2A27-A nrPDB 276 1e-74 5FET-A nrPDB 276 2e-74 5YV8-A nrPDB 276 2e-74 5JZN-A nrPDB 275 2e-74 1VZO-A nrPDB 275 3e-74 4CSV-A nrPDB 275 3e-74 2YCR-A nrPDB 275 3e-74 5DYK-A nrPDB 275 3e-74 3A8W-A nrPDB 275 4e-74 4PDS-A nrPDB 274 5e-74 6FD3-A nrPDB 274 5e-74 6AO5-A nrPDB 274 7e-74 5LOH-A nrPDB 274 7e-74 3UTO-A nrPDB 273 1e-73 2Y7J-A nrPDB 273 1e-73 4AF3-A nrPDB 273 1e-73 3I6U-A nrPDB 273 1e-73 1ZWS-A nrPDB 272 3e-73 6BDL-A nrPDB 272 3e-73 3TKU-A nrPDB 271 4e-73 1PHK-A nrPDB 271 4e-73 4C0T-A nrPDB 271 5e-73 1KOA-A nrPDB 271 5e-73 3GUB-A nrPDB 271 5e-73 4AW2-A nrPDB 270 7e-73 4AGU-A nrPDB 266 1e-71 4QMW-A nrPDB 266 1e-71 3NYO-A nrPDB 265 2e-71 2F57-A nrPDB 265 3e-71 3KN6-A nrPDB 265 3e-71 3NIZ-A nrPDB 265 3e-71 4TNB-A nrPDB 264 4e-71 2UV2-A nrPDB 264 7e-71 3Q53-A nrPDB 264 7e-71 4KS7-A nrPDB 264 9e-71 5J5T-A nrPDB 263 1e-70 4BBM-A nrPDB 262 3e-70 4APC-A nrPDB 262 3e-70 6CCF-A nrPDB 260 6e-70 3C51-A nrPDB 260 8e-70 2WQN-A nrPDB 260 9e-70 4FIE-A nrPDB 259 2e-69 4OTD-A nrPDB 259 2e-69 4WNO-A nrPDB 258 3e-69 2X4F-A nrPDB 258 3e-69 2XIK-A nrPDB 258 3e-69 4JDH-A nrPDB 258 4e-69 6QAU-A nrPDB 257 5e-69 4XBR-A nrPDB 257 6e-69 2Q0N-A nrPDB 257 6e-69 4FZF-B nrPDB 257 6e-69 3IS5-A nrPDB 257 6e-69 4KRC-A nrPDB 257 7e-69 6GU6-A nrPDB 257 8e-69 2BRG-A nrPDB 255 2e-68 6HXF-B nrPDB 255 2e-68 3FXW-A nrPDB 255 3e-68 5H2U-A nrPDB 255 4e-68 2WTK-C nrPDB 255 4e-68 4AU8-A nrPDB 254 5e-68 2FO0-A nrPDB 254 5e-68 4XEY-B nrPDB 254 5e-68 1KOB-A nrPDB 254 7e-68 3PPZ-A nrPDB 254 7e-68 3DAK-A nrPDB 254 9e-68 2XYN-A nrPDB 253 1e-67 4FR4-A nrPDB 253 1e-67 4CRS-A nrPDB 253 2e-67 6BXI-A nrPDB 252 2e-67 6NPU-A nrPDB 251 3e-67 5D7A-A nrPDB 251 4e-67 2HW6-A nrPDB 251 4e-67 2VD5-A nrPDB 251 5e-67 3OHT-A nrPDB 250 7e-67 4EBW-A nrPDB 250 1e-66 6E2O-A nrPDB 248 4e-66 1NY3-A nrPDB 248 4e-66 4YHJ-A nrPDB 248 4e-66 3KA0-A nrPDB 247 7e-66 2OZA-A nrPDB 247 7e-66 3ZDU-A nrPDB 247 8e-66 5UUU-A nrPDB 247 8e-66 1CM8-A nrPDB 247 9e-66 2H8H-A nrPDB 247 1e-65 2F9G-A nrPDB 246 1e-65 1V0B-A nrPDB 246 2e-65 4EWQ-A nrPDB 246 2e-65 4P5Q-A nrPDB 245 2e-65 3PVW-A nrPDB 245 2e-65 3DKO-A nrPDB 245 2e-65 5DBX-A nrPDB 245 2e-65 4IC8-A nrPDB 245 3e-65 4XCU-A nrPDB 244 5e-65 4LQP-A nrPDB 244 5e-65 4UY9-A nrPDB 244 5e-65 2J0K-A nrPDB 244 6e-65 5TUR-A nrPDB 244 7e-65 4E93-A nrPDB 244 7e-65 6F3F-A nrPDB 244 7e-65 4RC3-A nrPDB 244 9e-65 6CQF-A nrPDB 244 9e-65 3DTC-A nrPDB 243 1e-64 6DTL-A nrPDB 243 1e-64 2XNP-A nrPDB 243 1e-64 4MYG-A nrPDB 242 2e-64 2R2P-A nrPDB 242 2e-64 3BGP-A nrPDB 242 2e-64 3E7O-A nrPDB 242 3e-64 1UA2-A nrPDB 242 3e-64 1U5R-A nrPDB 242 3e-64 2Y6O-A nrPDB 242 3e-64 1JPA-A nrPDB 242 3e-64 4ZSG-A nrPDB 242 3e-64 5SYS-A nrPDB 241 4e-64 4QNY-A nrPDB 241 4e-64 5A46-A nrPDB 240 7e-64 5Z33-A nrPDB 240 7e-64 2GCD-A nrPDB 240 7e-64 3TT0-A nrPDB 240 9e-64 3OZ6-A nrPDB 240 1e-63 4AT3-A nrPDB 240 1e-63 4QTB-A nrPDB 240 1e-63 3HKO-A nrPDB 240 1e-63 5VO2-A nrPDB 239 2e-63 3GQL-A nrPDB 239 2e-63 4BGQ-A nrPDB 239 3e-63 4U41-A nrPDB 239 3e-63 2EHB-D nrPDB 239 3e-63 4X7Q-B nrPDB 239 3e-63 3KUL-B nrPDB 239 3e-63 5NGU-A nrPDB 239 3e-63 5AWM-A nrPDB 238 4e-63 3GC9-A nrPDB 238 4e-63 3V5Q-A nrPDB 238 4e-63 6GQK-A nrPDB 238 4e-63 1JNK-A nrPDB 238 4e-63 6CKI-A nrPDB 238 5e-63 5MJB-A nrPDB 237 6e-63 2VWV-A nrPDB 237 7e-63 5L6P-A nrPDB 237 7e-63 2XS0-A nrPDB 237 7e-63 4XLV-A nrPDB 236 1e-62 4UYA-A nrPDB 236 2e-62 2PSQ-A nrPDB 235 2e-62 5EFQ-A nrPDB 235 2e-62 2DQ7-X nrPDB 235 3e-62 1G3N-A nrPDB 234 5e-62 1K9A-A nrPDB 234 7e-62 4PDO-A nrPDB 234 7e-62 3DLS-A nrPDB 233 9e-62 3QGY-A nrPDB 233 1e-61 3ORP-A nrPDB 233 1e-61 5U6B-A nrPDB 233 1e-61 3LM0-A nrPDB 233 1e-61 4GS6-A nrPDB 233 1e-61 4K33-A nrPDB 232 2e-61 4HZS-A nrPDB 232 2e-61 3GC0-A nrPDB 232 2e-61 1BYG-A nrPDB 232 3e-61 4NST-A nrPDB 232 3e-61 3FI2-A nrPDB 232 3e-61 3SXS-A nrPDB 232 3e-61 5G6V-A nrPDB 231 4e-61 4O2Z-A nrPDB 231 4e-61 5KMM-A nrPDB 231 5e-61 3MIA-A nrPDB 231 5e-61 3PG1-A nrPDB 231 6e-61 1FVR-A nrPDB 230 7e-61 2PL0-A nrPDB 230 8e-61 3A4O-X nrPDB 230 1e-60 3BEA-A nrPDB 230 1e-60 2OGV-A nrPDB 230 1e-60 4H1J-A nrPDB 229 1e-60 2HK5-A nrPDB 229 2e-60 1U54-B nrPDB 228 3e-60 5EG3-A nrPDB 228 3e-60 5X5O-A nrPDB 228 3e-60 1LUF-A nrPDB 228 4e-60 3QUP-A nrPDB 227 7e-60 4AN9-A nrPDB 227 7e-60 3KRL-A nrPDB 227 9e-60 5AMN-A nrPDB 226 1e-59 3BBT-B nrPDB 225 2e-59 4R7H-A nrPDB 225 3e-59 3G0E-A nrPDB 225 3e-59 6DBM-A nrPDB 225 3e-59 4OLI-A nrPDB 225 3e-59 5O2B-A nrPDB 225 4e-59 5O2C-A nrPDB 224 7e-59 3AOX-A nrPDB 224 7e-59 2W96-B nrPDB 224 7e-59 6FEX-A nrPDB 224 7e-59 4XUF-A nrPDB 223 1e-58 4Y93-A nrPDB 223 1e-58 2I6L-A nrPDB 223 2e-58 4E7W-A nrPDB 223 2e-58 5AIR-A nrPDB 222 2e-58 2OZO-A nrPDB 222 2e-58 5X02-A nrPDB 222 3e-58 3CJF-A nrPDB 222 3e-58 5FM2-A nrPDB 222 3e-58 6GVJ-A nrPDB 222 3e-58 6BSD-A nrPDB 222 4e-58 4EQM-A nrPDB 221 4e-58 3PP0-A nrPDB 221 4e-58 1ZXE-A nrPDB 221 4e-58 6DBN-A nrPDB 221 4e-58 1U59-A nrPDB 221 6e-58 6E4F-A nrPDB 221 6e-58 3VN9-A nrPDB 221 6e-58 3PLS-A nrPDB 220 8e-58 5GRN-A nrPDB 220 9e-58 4E20-A nrPDB 220 1e-57 5HLW-A nrPDB 220 1e-57 4XI2-A nrPDB 220 1e-57 1TKI-A nrPDB 219 1e-57 3ZBF-A nrPDB 219 2e-57 4PWN-A nrPDB 219 2e-57 1AD5-A nrPDB 219 2e-57 3LZB-A nrPDB 218 3e-57 3FME-A nrPDB 218 3e-57 3I81-A nrPDB 218 3e-57 3C1X-A nrPDB 218 5e-57 5GNK-A nrPDB 218 5e-57 4YFF-A nrPDB 217 7e-57 4HVI-A nrPDB 217 1e-56 3HMP-A nrPDB 217 1e-56 3M42-A nrPDB 217 1e-56 5HI2-A nrPDB 216 1e-56 2W1I-A nrPDB 216 2e-56 3N9X-A nrPDB 216 2e-56 3IO7-A nrPDB 216 2e-56 5U6C-A nrPDB 215 2e-56 5HVK-A nrPDB 215 2e-56 5HIE-A nrPDB 215 3e-56 5O0Y-A nrPDB 215 4e-56 5KKR-C nrPDB 215 4e-56 5AP3-A nrPDB 214 7e-56 2ZMD-A nrPDB 213 8e-56 4LRM-A nrPDB 213 2e-55 3EQC-A nrPDB 213 2e-55 5Y86-A nrPDB 212 2e-55 3OMV-A nrPDB 212 2e-55 5WNO-A nrPDB 212 3e-55 3E3P-A nrPDB 212 3e-55 3ALO-A nrPDB 212 4e-55 3NIE-A nrPDB 210 7e-55 4NEU-A nrPDB 210 9e-55 6FER-A nrPDB 210 1e-54 4Y83-A nrPDB 209 2e-54 4OW8-A nrPDB 209 2e-54 4X3F-A nrPDB 209 2e-54 6B2Q-A nrPDB 209 2e-54 4TPT-A nrPDB 208 5e-54 1S9I-A nrPDB 207 6e-54 4FL3-A nrPDB 207 8e-54 5UIU-A nrPDB 206 2e-53 3QA8-A nrPDB 205 2e-53 3EB0-A nrPDB 205 3e-53 5ZTN-A nrPDB 205 4e-53 4M7I-A nrPDB 203 1e-52 5C26-A nrPDB 203 1e-52 5CEK-A nrPDB 203 2e-52 6DC0-A nrPDB 203 2e-52 4C59-A nrPDB 203 2e-52 5X8I-B nrPDB 202 2e-52 4IDT-A nrPDB 202 4e-52 5TQX-A nrPDB 202 4e-52 5B2L-A nrPDB 201 6e-52 4KIK-B nrPDB 200 1e-51 4F0G-A nrPDB 200 1e-51 3ZZW-A nrPDB 199 2e-51 5VD3-A nrPDB 199 3e-51 6CTH-A nrPDB 198 3e-51 5WNL-A nrPDB 198 5e-51 5TOS-A nrPDB 197 8e-51 6FYV-A nrPDB 196 2e-50 2WTK-B nrPDB 195 2e-50 3LMG-A nrPDB 194 6e-50 5TE0-A nrPDB 193 9e-50 2H34-A nrPDB 193 1e-49 3RP9-A nrPDB 192 3e-49 2PMN-X nrPDB 192 4e-49 2A1A-B nrPDB 191 5e-49 2BUJ-A nrPDB 190 7e-49 5LPZ-A nrPDB 190 9e-49 6J5U-C nrPDB 190 9e-49 5LPV-A nrPDB 190 1e-48 6O6Q-A nrPDB 189 2e-48 4G3E-A nrPDB 189 2e-48 2WO6-A nrPDB 188 4e-48 3UIU-A nrPDB 188 5e-48 5IKW-A nrPDB 187 1e-47 3Q4U-A nrPDB 185 3e-47 2RIO-A nrPDB 184 6e-47 3MY0-A nrPDB 183 1e-46 4JLC-A nrPDB 181 4e-46 5L2Q-C nrPDB 181 4e-46 4EUU-A nrPDB 181 4e-46 5AR8-A nrPDB 181 6e-46 5VC6-A nrPDB 181 7e-46 5UNP-A nrPDB 180 1e-45 4EUT-A nrPDB 180 1e-45 5XVU-A nrPDB 179 2e-45 3UIM-A nrPDB 178 5e-45 2PVN-A nrPDB 177 7e-45 4PL5-B nrPDB 177 7e-45 3MDY-A nrPDB 177 9e-45 4CRL-A nrPDB 177 1e-44 6O8B-A nrPDB 177 1e-44 6NT9-A nrPDB 176 1e-44 4MD7-E nrPDB 176 1e-44 2Y4I-B nrPDB 176 1e-44 3RAW-A nrPDB 176 2e-44 6HV0-A nrPDB 175 5e-44 1PY5-A nrPDB 174 5e-44 6HMD-A nrPDB 173 2e-43 6EII-A nrPDB 172 3e-43 5XD6-A nrPDB 172 3e-43 4WUA-A nrPDB 171 4e-43 2JD5-A nrPDB 170 9e-43 2X7G-A nrPDB 170 1e-42 3REP-A nrPDB 169 2e-42 5E8V-A nrPDB 168 5e-42 6BFN-A nrPDB 167 7e-42 2QKW-B nrPDB 167 7e-42 4M66-A nrPDB 165 4e-41 3SOC-A nrPDB 163 1e-40 4IAN-A nrPDB 162 3e-40 4LFI-A nrPDB 161 5e-40 4L00-A nrPDB 158 4e-39 3QD2-B nrPDB 158 4e-39 4M69-B nrPDB 158 4e-39 3LLT-A nrPDB 158 4e-39 4BTF-A nrPDB 158 4e-39 3HNG-A nrPDB 155 3e-38 5USZ-A nrPDB 155 5e-38 3SV0-A nrPDB 155 5e-38 4F9B-A nrPDB 155 5e-38 3G2F-A nrPDB 153 1e-37 2QLU-A nrPDB 153 2e-37 5X1R-A nrPDB 153 2e-37 4TN6-A nrPDB 150 2e-36 5FQD-C nrPDB 150 2e-36 4RT7-A nrPDB 147 1e-35 5X18-A nrPDB 146 1e-35 4BTK-A nrPDB 145 3e-35 2CHL-A nrPDB 145 3e-35 2CMW-A nrPDB 145 4e-35 4NFN-A nrPDB 145 5e-35 2C47-A nrPDB 143 1e-34 5M07-A nrPDB 141 4e-34 2PZI-A nrPDB 141 8e-34 4Y12-A nrPDB 140 1e-33 4NT4-A nrPDB 138 3e-33 4XHH-A nrPDB 132 3e-31 4XHL-A nrPDB 129 2e-30 4JRN-A nrPDB 129 3e-30 2ZFD-B nrPDB 121 4e-28 6J6I-B nrPDB 121 7e-28 5OAT-A nrPDB 120 1e-27 4OAU-C nrPDB 104 8e-23 4O1O-A nrPDB 101 9e-22 5CLR-A nrPDB 94 1e-19 Sequences not found previously or not previously below threshold: 5VDK-A nrPDB 162 4e-40 3VHK-A nrPDB 157 7e-39 4MWI-A nrPDB 151 4e-37 5J0A-A nrPDB 142 3e-34 1CSN-A nrPDB 131 4e-31 5C01-A nrPDB 130 1e-30 4WOV-A nrPDB 129 2e-30 4I94-A nrPDB 118 5e-27 4L68-A nrPDB 114 7e-26 6EQI-C nrPDB 113 2e-25 5UV4-A nrPDB 110 1e-24 5UU1-A nrPDB 91 6e-19 6EAS-A nrPDB 86 3e-17 4IX6-A nrPDB 83 3e-16 2RSV-A nrPDB 80 2e-15 2LAV-A nrPDB 80 3e-15 5DMZ-A nrPDB 76 3e-14 6G4J-A nrPDB 74 2e-13 6EWX-A nrPDB 72 4e-13 6BHC-A nrPDB 70 3e-12 6M7Z-A nrPDB 67 2e-11 4CI6-B nrPDB 67 2e-11 5GZA-A nrPDB 66 4e-11 5VE6-A nrPDB 65 5e-11 5GZ9-A nrPDB 64 1e-10 2JII-A nrPDB 58 1e-08 4AZW-A nrPDB 56 5e-08 4AZV-A nrPDB 55 6e-08 3ENH-A nrPDB 53 2e-07 3BYV-A nrPDB 53 2e-07 4CZY-B nrPDB 52 6e-07 3L19-A nrPDB 51 7e-07 4CYJ-A nrPDB 51 9e-07 2W1Z-A nrPDB 51 1e-06 3DZO-A nrPDB 49 3e-06 6G38-A nrPDB 47 2e-05 4WWA-A nrPDB 46 2e-05 3Q60-A nrPDB 46 4e-05 6R5K-O nrPDB 42 4e-04 1TQM-A nrPDB 42 4e-04 4BWP-A nrPDB 41 0.001 4XR7-L nrPDB 41 0.001 4BVU-A nrPDB 41 0.001 5YK0-A nrPDB 38 0.006 6G5I-z nrPDB 38 0.010 4OTP-A nrPDB 38 0.010 1L1L-A nrPDB 34 0.11 >4D28-A nrPDB Length = 446 Score = 681 bits (1758), Expect = 0.0, Method: Composition-based stats. Identities = 438/446 (98%), Positives = 439/446 (98%) Query: 1 MTKKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREI 60 MTKKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREI Sbjct: 1 MTKKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREI 60 Query: 61 SIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVD 120 SIMKIVRHPNIVRLYEVLAS SKIYIVLEFVTGGELFDRIVHKGRL+E ESRKYFQQLVD Sbjct: 61 SIMKIVRHPNIVRLYEVLASKSKIYIVLEFVTGGELFDRIVHKGRLKEDESRKYFQQLVD 120 Query: 121 AVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEV 180 AVAHCH KGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELL TCGTPNYVAPEV Sbjct: 121 AVAHCHSKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLNDTCGTPNYVAPEV 180 Query: 181 LSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFL 240 LSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEF CPPWFSAEVKFL Sbjct: 181 LSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFDCPPWFSAEVKFL 240 Query: 241 IHRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEVNLDDIRAVFDGIEGSYVAENV 300 IHRILDPNPKTRIQIQGIKKDPWFR NYVPIRAREEEEVNLDDIRAVFDGIEGSYVAENV Sbjct: 241 IHRILDPNPKTRIQIQGIKKDPWFRKNYVPIRAREEEEVNLDDIRAVFDGIEGSYVAENV 300 Query: 301 ERNDEGPLMMNAFEMITLSQGLNLSALFDRRQDFVKRQTRFVSRREPSEIIANIEAVANS 360 ERNDEGPLMMNAFEMITLSQGLNLSALFDRRQDFVKRQTRFVSRREPSEIIANIEAVANS Sbjct: 301 ERNDEGPLMMNAFEMITLSQGLNLSALFDRRQDFVKRQTRFVSRREPSEIIANIEAVANS 360 Query: 361 MGFKSHTRNFKTRLEGLSSIKAGQLAVVIEIYEVAPSLFMVDVRKAAGETLEYHKFYKKL 420 MGFKSHTRNFKTRLEGLSSIKAGQLAVVIEIYEVAPSLFMVDVRKAAGETLEYHKFYKKL Sbjct: 361 MGFKSHTRNFKTRLEGLSSIKAGQLAVVIEIYEVAPSLFMVDVRKAAGETLEYHKFYKKL 420 Query: 421 CSKLENIIWRATEGIPKSEILRTITF 446 CSKLENIIWRATEGIPKSEILRTITF Sbjct: 421 CSKLENIIWRATEGIPKSEILRTITF 446 >4CZT-A nrPDB Length = 464 Score = 554 bits (1428), Expect = e-158, Method: Composition-based stats. Identities = 259/432 (59%), Positives = 334/432 (77%), Gaps = 7/432 (1%) Query: 7 RVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIV 66 RVGKYE+GRT+GEGTFAKVKFARN + GDNVAIK++ K +LKN+M+ QIKREIS MK++ Sbjct: 9 RVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLI 68 Query: 67 RHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCH 126 +HPN++R++EV+AS +KIY VLEFVTGGELFD+I GRL+E E+RKYFQQL++AV +CH Sbjct: 69 KHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCH 128 Query: 127 CKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQE--GVELLRTTCGTPNYVAPEVLSGQ 184 +GVYHRDLKPENLLLD NG LKVSDFGLSALPQ+ LL TTCGTPNYVAPEV++ + Sbjct: 129 SRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNK 188 Query: 185 GYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRI 244 GYDG+ AD+WSCGVILFV++AGYLPF +++L LY+KI AEF+CPPWFSA K LI RI Sbjct: 189 GYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIKRI 248 Query: 245 LDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEVNLDDIRAVFDGIEGSYVAENVERND 304 LDPNP TRI + ++ WF+ Y E +V+LDD+ A+FD G VER + Sbjct: 249 LDPNPATRITFAEVIENEWFKKGYK-APKFENADVSLDDVDAIFDD-SGESKNLVVERRE 306 Query: 305 EG---PLMMNAFEMITLSQGLNLSALFDRRQDFVKRQTRFVSRREPSEIIANIEAVANSM 361 EG P+ MNAFE+I+ SQGLNL +LF+++ VKR+TRF S+ +EI+ IEA A M Sbjct: 307 EGLKTPVTMNAFELISTSQGLNLGSLFEKQMGLVKRKTRFTSKSSANEIVTKIEAAAAPM 366 Query: 362 GFKSHTRNFKTRLEGLSSIKAGQLAVVIEIYEVAPSLFMVDVRKAAGETLEYHKFYKKLC 421 GF T N+K +L G S + GQLAV E+++VAPSL+MV++RK+ G+TLE+HKFYK L Sbjct: 367 GFDVKTNNYKMKLTGEKSGRKGQLAVATEVFQVAPSLYMVEMRKSGGDTLEFHKFYKNLT 426 Query: 422 SKLENIIWRATE 433 + L++I+W+ + Sbjct: 427 TGLKDIVWKTID 438 >3H4J-B nrPDB Length = 336 Score = 358 bits (918), Expect = 4e-99, Method: Composition-based stats. Identities = 135/329 (41%), Positives = 213/329 (64%), Gaps = 9/329 (2%) Query: 1 MTKKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREI 60 M R +G Y + T+GEG+F KVK A + T VA+K +++ + K+ M +++REI Sbjct: 1 MAISKRHIGPYIIRETLGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREI 60 Query: 61 SIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVD 120 S +K++RHP+I++LY+V+ +P+ I +V+E+ GGELFD IV K R+ E E R++FQQ++ Sbjct: 61 SYLKLLRHPHIIKLYDVITTPTDIVMVIEYA-GGELFDYIVEKKRMTEDEGRRFFQQIIC 119 Query: 121 AVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEV 180 A+ +CH + HRDLKPENLLLD N N+K++DFGLS + +G L+T+CG+PNY APEV Sbjct: 120 AIEYCHRHKIVHRDLKPENLLLDDNLNVKIADFGLSNIMTDGN-FLKTSCGSPNYAAPEV 178 Query: 181 LSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFL 240 ++G+ Y G D+WSCG++L+V+L G LPF + +P L++K+N+ + P + S + L Sbjct: 179 INGKLYAGPEVDVWSCGIVLYVMLVGRLPFDDEFIPNLFKKVNSCVYVMPDFLSPGAQSL 238 Query: 241 IHRILDPNPKTRIQIQGIKKDPWFRLNYVP-IRAREEEEVNLDDIRAVFD-----GIEGS 294 I R++ +P RI IQ I++DPWF +N +R EE + + D R V G Sbjct: 239 IRRMIVADPMQRITIQEIRRDPWFNVNLPDYLRPMEEVQGSYADSRIVSKLGEAMGFSED 298 Query: 295 YVAENVERNDEGPLMMNAFEMITLSQGLN 323 Y+ E + R+DE + A+ ++ +Q + Sbjct: 299 YIVEAL-RSDENNEVKEAYNLLHENQVIQ 326 >5JN2-A nrPDB Length = 525 Score = 343 bits (880), Expect = 1e-94, Method: Composition-based stats. Identities = 108/415 (26%), Positives = 200/415 (48%), Gaps = 43/415 (10%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 +Y+ R +G+G+F +V ++ TG A+K+++K + + + + RE+ ++K + H Sbjct: 67 DRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDH 126 Query: 69 PNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCK 128 PNI++LYE Y+V E TGGELFD I+ + R E ++ + +Q++ + + H Sbjct: 127 PNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKN 186 Query: 129 GVYHRDLKPENLLL---DTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQG 185 + HRDLKPENLLL + N+++ DFGLS E + ++ GT Y+APEVL G Sbjct: 187 KIVHRDLKPENLLLESKSKDANIRIIDFGLSTHF-EASKKMKDKIGTAYYIAPEVLHGT- 244 Query: 186 YDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSC--PPW--FSAEVKFLI 241 D+WS GVIL+++L+G PF+ + + +K+ +++ P W S K LI Sbjct: 245 -YDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFELPQWKKVSESAKDLI 303 Query: 242 HRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEVNLDDIRAVFDGIEGSYVAENVE 301 ++L P RI + W + E++++ D+ ++ + I + + Sbjct: 304 RKMLTYVPSMRISARDALDHEWIQTYTK-------EQISV-DVPSLDNAILNIRQFQGTQ 355 Query: 302 RNDEGPLMMNAFEMITLSQGLNLSALFDRRQDFVKRQTRFVSRREPSEIIANIEAVANSM 361 + + L+ ++ + + L+A+F + Q + +E+I + + Sbjct: 356 KLAQAALLYMGSKLTSQDETKELTAIFHKMDKNGDGQL------DRAELIEGYKEL---- 405 Query: 362 GFKSHTRNFKTRLEGLSSIKAGQLAVVIEIYEVAPSLFMVDVRKAAGETLEYHKF 416 R++G + AV E+ +V + VD K +EY +F Sbjct: 406 ----------MRMKGQDASMLDASAVEHEVDQVLDA---VDFDKNG--YIEYSEF 445 >3NCG-A nrPDB Length = 486 Score = 343 bits (879), Expect = 1e-94, Method: Composition-based stats. Identities = 96/330 (29%), Positives = 175/330 (53%), Gaps = 18/330 (5%) Query: 8 VGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR 67 +Y + +G+G+F +V ++ T A+K++ K++ KN+ I RE+ ++K + Sbjct: 21 AERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASA-KNKDTSTILREVELLKKLD 79 Query: 68 HPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHC 127 HPNI++L+E+L S YIV E TGGELFD I+ + R E ++ + +Q+ + + H Sbjct: 80 HPNIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMHK 139 Query: 128 KGVYHRDLKPENLLLDT---NGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQ 184 + HRDLKPEN+LL++ + ++K+ DFGLS Q+ + ++ GT Y+APEVL G Sbjct: 140 HNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTK-MKDRIGTAYYIAPEVLRGT 198 Query: 185 GYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSC--PPW--FSAEVKFL 240 D+WS GVIL+++L+G PF + + +++ +++ P W S + K L Sbjct: 199 --YDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRVETGKYAFDLPQWRTISDDAKDL 256 Query: 241 IHRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEVNLDDIRAVFDGIEGSYVAENV 300 I ++L +P RI + PW + E + D+ ++ + + Sbjct: 257 IRKMLTFHPSLRITATQCLEHPWIQK-------YSSETPTISDLPSLESAMTNIRQFQAE 309 Query: 301 ERNDEGPLMMNAFEMITLSQGLNLSALFDR 330 ++ + L+ A ++ TL + L+ +F + Sbjct: 310 KKLAQAALLYMASKLTTLDETKQLTEIFRK 339 >3LIJ-A nrPDB Length = 494 Score = 337 bits (865), Expect = 6e-93, Method: Composition-based stats. Identities = 106/384 (27%), Positives = 197/384 (51%), Gaps = 32/384 (8%) Query: 2 TKKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREIS 61 +KK Y+ + +G G + +V R+ T AIKI+ K+++ + ++ E++ Sbjct: 30 SKKGHLSEMYQRVKKLGSGAYGEVLLCRDKVTHVERAIKIIRKTSVSTSS-NSKLLEEVA 88 Query: 62 IMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDA 121 ++K++ HPNI++LY+ Y+V+E GGELFD I+H+ + E ++ +Q++ Sbjct: 89 VLKLLDHPNIMKLYDFFEDKRNYYLVMECYKGGELFDEIIHRMKFNEVDAAVIIKQVLSG 148 Query: 122 VAHCHCKGVYHRDLKPENLLLDT---NGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAP 178 V + H + HRDLKPENLLL++ + +K+ DFGLSA+ E + ++ GT Y+AP Sbjct: 149 VTYLHKHNIVHRDLKPENLLLESKEKDALIKIVDFGLSAVF-ENQKKMKERLGTAYYIAP 207 Query: 179 EVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSC--PPW--FS 234 EVL + D+WS GVILF++LAGY PF + RK+ +++ P W S Sbjct: 208 EVLRKK--YDEKCDVWSIGVILFILLAGYPPFGGQTDQEILRKVEKGKYTFDSPEWKNVS 265 Query: 235 AEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEVNLDDIRAVFDGIEGS 294 K LI ++L + + RI Q + PW + + +++E + L ++ + IE Sbjct: 266 EGAKDLIKQMLQFDSQRRISAQQALEHPWIK----EMCSKKESGIELP---SLANAIENM 318 Query: 295 YVAENVERNDEGPLMMNAFEMITLSQGLNLSALFD----------RRQDFVKRQTRF--- 341 +N ++ + L+ A ++ + + L+ +F RQ+ + ++ Sbjct: 319 RKFQNSQKLAQAALLYMASKLTSQEETKELTDIFRHIDKNGDGQLDRQELIDGYSKLSGE 378 Query: 342 -VSRREPSEIIANIEAVANSMGFK 364 V+ + +I + ++A+ + F Sbjct: 379 EVAVFDLPQIESEVDAILGAADFD 402 >4CFF-A nrPDB Length = 571 Score = 336 bits (861), Expect = 2e-92, Method: Composition-based stats. Identities = 140/377 (37%), Positives = 215/377 (57%), Gaps = 18/377 (4%) Query: 1 MTKKMRR-----VGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQ 55 M +K + +G Y +G T+G GTF KVK + TG VA+KI+ + I +V + Sbjct: 20 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGK 79 Query: 56 IKREISIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYF 115 IKREI +K+ RHP+I++LY+V+++P+ ++V+E+V+GGELFD I GR+EE E+R+ F Sbjct: 80 IKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLF 139 Query: 116 QQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNY 175 QQ++ AV +CH V HRDLKPEN+LLD + N K++DFGLS + +G E LRT+CG+PNY Sbjct: 140 QQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDG-EFLRTSCGSPNY 198 Query: 176 VAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSA 235 APEV+SG+ Y G DIWSCGVIL+ +L G LPF + +P L++KI F P + + Sbjct: 199 AAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNR 258 Query: 236 EVKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEVNLDDIRAVFDGIEGSY 295 V L+ +L +P R I+ I++ WF+ + +P E+ ++ E Sbjct: 259 SVATLLMHMLQVDPLKRATIKDIREHEWFKQD-LPSYLFPEDPSYDANVIDDEAVKEVCE 317 Query: 296 VAENVERNDEGPLMMNAFEMITLSQGLNLSA----LFDRRQDFVKRQTRFVSRREPSEII 351 E E +MN+ + + L+ + D R+ + +++ PS Sbjct: 318 KFECTE-----SEVMNS--LYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSF 370 Query: 352 ANIEAVANSMGFKSHTR 368 + A+ G K H Sbjct: 371 MDDSAMHIPPGLKPHPE 387 >4REW-A nrPDB Length = 540 Score = 335 bits (859), Expect = 2e-92, Method: Composition-based stats. Identities = 133/322 (41%), Positives = 201/322 (62%), Gaps = 10/322 (3%) Query: 7 RVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIV 66 ++G Y +G T+G GTF KVK ++ TG VA+KI+ + I +V +I+REI +K+ Sbjct: 4 KIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLF 63 Query: 67 RHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCH 126 RHP+I++LY+V+++PS I++V+E+V+GGELFD I GRL+E ESR+ FQQ++ V +CH Sbjct: 64 RHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCH 123 Query: 127 CKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGY 186 V HRDLKPEN+LLD + N K++DFGLS + +G E LRT+CG+PNY APEV+SG+ Y Sbjct: 124 RHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDG-EFLRTSCGSPNYAAPEVISGRLY 182 Query: 187 DGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILD 246 G DIWS GVIL+ +L G LPF + +P L++KI F P + + V L+ +L Sbjct: 183 AGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQ 242 Query: 247 PNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEVNLD--DIRAVFDGIEGSYVAENV---- 300 +P R I+ I++ WF+ + E+ + D A+ + E +E Sbjct: 243 VDPMKRASIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSC 302 Query: 301 --ERNDEGPLMMNAFEMITLSQ 320 RN + PL + A+ +I ++ Sbjct: 303 LYNRNHQDPLAV-AYHLIIDNR 323 >5EZV-A nrPDB Length = 560 Score = 332 bits (853), Expect = 1e-91, Method: Composition-based stats. Identities = 132/344 (38%), Positives = 203/344 (59%), Gaps = 12/344 (3%) Query: 7 RVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIV 66 ++G Y +G T+G GTF KVK + TG VA+KI+ + I +V +IKREI +K+ Sbjct: 26 KIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLF 85 Query: 67 RHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCH 126 RHP+I++LY+V+++P+ ++V+E+V+GGELFD I GR+EE E+R+ FQQ++ AV +CH Sbjct: 86 RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCH 145 Query: 127 CKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGY 186 V HRDLKPEN+LLD + N K++DFGLS + +G E LRT+CG+PNY APEV+SG+ Y Sbjct: 146 RHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDG-EFLRTSCGSPNYAAPEVISGRLY 204 Query: 187 DGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILD 246 G DIWSCGVIL+ +L G LPF + +P L++KI F P + + V L+ +L Sbjct: 205 AGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQ 264 Query: 247 PNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEVNLDDIRAVFDGIEGSYVAENVERNDEG 306 +P R I+ I++ WF+ + +P E+ ++ E E E Sbjct: 265 VDPLKRATIKDIREHEWFKQD-LPSYLFPEDPSYDANVIDDEAVKEVCEKFECTE----- 318 Query: 307 PLMMNAFEMITLSQGLNLSALFD---RRQDFVKRQTRFVSRREP 347 +MN+ + + L+ + + + + + F P Sbjct: 319 SEVMNS--LYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSP 360 >3MN3-A nrPDB Length = 271 Score = 330 bits (847), Expect = 7e-91, Method: Composition-based stats. Identities = 120/262 (45%), Positives = 183/262 (69%), Gaps = 2/262 (0%) Query: 6 RRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKI 65 +G Y++ +T+GEG+F KVK A +T TG VA+KI+ K + K+ M +I+REIS +++ Sbjct: 1 AHIGNYQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRL 60 Query: 66 VRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHC 125 +RHP+I++LY+V+ S +I +V+E+ G ELFD IV + ++ E E+R++FQQ++ AV +C Sbjct: 61 LRHPHIIKLYDVIKSKDEIIMVIEYA-GNELFDYIVQRDKMSEQEARRFFQQIISAVEYC 119 Query: 126 HCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQG 185 H + HRDLKPENLLLD + N+K++DFGLS + +G L+T+CG+PNY APEV+SG+ Sbjct: 120 HRHKIVHRDLKPENLLLDEHLNVKIADFGLSNIMTDGN-FLKTSCGSPNYAAPEVISGKL 178 Query: 186 YDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRIL 245 Y G D+WSCGVIL+V+L LPF + +P L++ I+ ++ P + S LI R+L Sbjct: 179 YAGPEVDVWSCGVILYVMLCRRLPFDDESIPVLFKNISNGVYTLPKFLSPGAAGLIKRML 238 Query: 246 DPNPKTRIQIQGIKKDPWFRLN 267 NP RI I I +D WF+++ Sbjct: 239 IVNPLNRISIHEIMQDDWFKVD 260 >4RED-A nrPDB Length = 351 Score = 330 bits (847), Expect = 7e-91, Method: Composition-based stats. Identities = 133/322 (41%), Positives = 201/322 (62%), Gaps = 10/322 (3%) Query: 7 RVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIV 66 ++G Y +G T+G GTF KVK ++ TG VA+KI+ + I +V +I+REI +K+ Sbjct: 12 KIGHYILGDTLGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVVGKIRREIQNLKLF 71 Query: 67 RHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCH 126 RHP+I++LY+V+++PS I++V+E+V+GGELFD I GRL+E ESR+ FQQ++ V +CH Sbjct: 72 RHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCH 131 Query: 127 CKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGY 186 V HRDLKPEN+LLD + N K++DFGLS + +G E LRT+CG+PNY APEV+SG+ Y Sbjct: 132 RHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDG-EFLRTSCGSPNYAAPEVISGRLY 190 Query: 187 DGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILD 246 G DIWS GVIL+ +L G LPF + +P L++KI F P + + V L+ +L Sbjct: 191 AGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQ 250 Query: 247 PNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEVNLD--DIRAVFDGIEGSYVAENV---- 300 +P R I+ I++ WF+ + E+ + D A+ + E +E Sbjct: 251 VDPMKRASIKDIREHEWFKQDLPKYLFPEDPSYSTTMIDDEALKEVCEKFECSEEEVLSC 310 Query: 301 --ERNDEGPLMMNAFEMITLSQ 320 RN + PL + A+ +I ++ Sbjct: 311 LYNRNHQDPLAV-AYHLIIDNR 331 >4CFH-A nrPDB Length = 493 Score = 330 bits (846), Expect = 8e-91, Method: Composition-based stats. Identities = 135/333 (40%), Positives = 204/333 (61%), Gaps = 15/333 (4%) Query: 1 MTKKMRR-----VGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQ 55 M +K + +G Y +G T+G GTF KVK ++ TG VA+KI+ + I +V + Sbjct: 20 MAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGK 79 Query: 56 IKREISIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYF 115 I+REI +K+ RHP+I++LY+V+++PS I++V+E+V+GGELFD I GRL+E ESR+ F Sbjct: 80 IRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLF 139 Query: 116 QQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNY 175 QQ++ V +CH V HRDLKPEN+LLD + N K++DFGLS + +G E LRT+CG+PNY Sbjct: 140 QQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDG-EFLRTSCGSPNY 198 Query: 176 VAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSA 235 APEV+SG+ Y G DIWS GVIL+ +L G LPF + +P L++KI F P + + Sbjct: 199 AAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNP 258 Query: 236 EVKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEVNLD--DIRAVFDGIEG 293 V L+ +L +P R I+ I++ WF+ + E+ + D A+ + E Sbjct: 259 SVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEK 318 Query: 294 SYVAENV------ERNDEGPLMMNAFEMITLSQ 320 +E RN + PL + A+ +I ++ Sbjct: 319 FECSEEEVLSCLYNRNHQDPLAV-AYHLIIDNR 350 >5KZ7-A nrPDB Length = 346 Score = 328 bits (842), Expect = 3e-90, Method: Composition-based stats. Identities = 115/302 (38%), Positives = 183/302 (60%), Gaps = 4/302 (1%) Query: 2 TKKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREIS 61 + +G Y + +TIG+G FAKVK AR+ TG VA+KI+ K+ + + + ++ RE+ Sbjct: 26 ADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSS-LQKLFREVR 84 Query: 62 IMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDA 121 IMK++ HPNIV+L+EV+ + +Y+V+E+ +GGE+FD +V GR++E E+R F+Q+V A Sbjct: 85 IMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSA 144 Query: 122 VAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVL 181 V +CH K + HRDLK ENLLLD + N+K++DFG S G + L T CG+P Y APE+ Sbjct: 145 VQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNK-LDTFCGSPPYAAPELF 203 Query: 182 SGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLI 241 G+ YDG D+WS GVIL+ +++G LPF +L L ++ ++ P + S + + L+ Sbjct: 204 QGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLL 263 Query: 242 HRILDPNPKTRIQIQGIKKDPWFRLNYV--PIRAREEEEVNLDDIRAVFDGIEGSYVAEN 299 + L NP R ++ I KD W + + ++ E + D R + Y E Sbjct: 264 KKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREE 323 Query: 300 VE 301 ++ Sbjct: 324 IQ 325 >5ES1-A nrPDB Length = 328 Score = 327 bits (840), Expect = 4e-90, Method: Composition-based stats. Identities = 121/304 (39%), Positives = 182/304 (59%), Gaps = 4/304 (1%) Query: 2 TKKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREIS 61 ++ VG Y + RTIG+G FAKVK AR+ TG VAIKI+ K T L + ++ RE+ Sbjct: 8 PEEQPHVGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDK-TQLNPSSLQKLFREVR 66 Query: 62 IMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDA 121 IMK + HPNIV+L+EV+ + +Y+V+E+ + GE+FD +V GR++E E+R F+Q+V A Sbjct: 67 IMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSA 126 Query: 122 VAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVL 181 V +CH K + HRDLK ENLLLD N+K++DFG S G L T CG+P Y APE+ Sbjct: 127 VHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLG-SKLDTFCGSPPYAAPELF 185 Query: 182 SGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLI 241 G+ YDG DIWS GVIL+ +++G LPF +L L ++ ++ P + S + + ++ Sbjct: 186 QGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESIL 245 Query: 242 HRILDPNPKTRIQIQGIKKDPWFRLNY--VPIRAREEEEVNLDDIRAVFDGIEGSYVAEN 299 R L NP R ++ I KD W + Y ++ E E + D + + + Y E Sbjct: 246 RRFLVLNPAKRCTLEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREE 305 Query: 300 VERN 303 ++ + Sbjct: 306 IKES 309 >2QNJ-A nrPDB Length = 328 Score = 326 bits (836), Expect = 1e-89, Method: Composition-based stats. Identities = 119/304 (39%), Positives = 186/304 (61%), Gaps = 4/304 (1%) Query: 2 TKKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREIS 61 + + +G Y + +TIG+G FAKVK AR+ TG VAIKI+ K T L + ++ RE+ Sbjct: 5 SDEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDK-TQLNPTSLQKLFREVR 63 Query: 62 IMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDA 121 IMKI+ HPNIV+L+EV+ + +Y+++E+ +GGE+FD +V GR++E E+R F+Q+V A Sbjct: 64 IMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSA 123 Query: 122 VAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVL 181 V +CH K + HRDLK ENLLLD + N+K++DFG S G + L T CG+P Y APE+ Sbjct: 124 VQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGK-LDTFCGSPPYAAPELF 182 Query: 182 SGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLI 241 G+ YDG D+WS GVIL+ +++G LPF +L L ++ ++ P + S + + L+ Sbjct: 183 QGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLL 242 Query: 242 HRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAR--EEEEVNLDDIRAVFDGIEGSYVAEN 299 R L NP R ++ I KD W + + E E+++ D + + + Y E Sbjct: 243 KRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEE 302 Query: 300 VERN 303 ++ + Sbjct: 303 IQES 306 >2YZA-A nrPDB Length = 276 Score = 325 bits (833), Expect = 3e-89, Method: Composition-based stats. Identities = 121/261 (46%), Positives = 178/261 (68%), Gaps = 1/261 (0%) Query: 7 RVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIV 66 ++G Y +G T+G GTF KVK + TG VA+KI+ + I +V +IKREI +K+ Sbjct: 9 KIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLF 68 Query: 67 RHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCH 126 RHP+I++LY+V+++P+ ++V+E+V+GGELFD I GR+EE E+R+ FQQ++ AV +CH Sbjct: 69 RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCH 128 Query: 127 CKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGY 186 V HRDLKPEN+LLD + N K++DFGLS + +G E LR +CG+PNY APEV+SG+ Y Sbjct: 129 RHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDG-EFLRDSCGSPNYAAPEVISGRLY 187 Query: 187 DGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILD 246 G DIWSCGVIL+ +L G LPF + +P L++KI F P + + V L+ +L Sbjct: 188 AGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQ 247 Query: 247 PNPKTRIQIQGIKKDPWFRLN 267 +P R I+ I++ WF+ + Sbjct: 248 VDPLKRATIKDIREHEWFKQD 268 >3HZT-A nrPDB Length = 467 Score = 323 bits (829), Expect = 7e-89, Method: Composition-based stats. Identities = 99/380 (26%), Positives = 183/380 (48%), Gaps = 34/380 (8%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 +Y+ + +G G + +V ++ TG AIKI+ KS++ + E++++K + H Sbjct: 4 DRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDH 63 Query: 69 PNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCK 128 PNI++LYE Y+V+E GGELFD I+ + + E ++ +Q++ + H Sbjct: 64 PNIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSGTTYLHKH 123 Query: 129 GVYHRDLKPENLLLDT---NGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQG 185 + HRDLKPENLLL++ + +K+ DFGLSA + G + ++ GT Y+APEVL + Sbjct: 124 NIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGK-MKERLGTAYYIAPEVLRKK- 181 Query: 186 YDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPP----WFSAEVKFLI 241 D+WSCGVIL+++L GY PF + +++ +FS P S E K L+ Sbjct: 182 -YDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKGKFSFDPPDWTQVSDEAKQLV 240 Query: 242 HRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEVNLDDIRAVFDGIEGSYVAENVE 301 +L P RI + PW + + + + + A+ + ++ + Sbjct: 241 KLMLTYEPSKRISAEEALNHPWI-VKFCSQKHTDVGK------HALTGALGNMKKFQSSQ 293 Query: 302 RNDEGPLMMNAFEMITLSQGLNLSALF-----------------DRRQDFVKRQTRFVSR 344 + + ++ ++ TL + L+ +F + + ++ + VS Sbjct: 294 KLAQAAMLFMGSKLTTLEETKELTQIFRQLDNNGDGQLDRKELIEGYRKLMQWKGDTVSD 353 Query: 345 REPSEIIANIEAVANSMGFK 364 + S+I A ++ + S+ F Sbjct: 354 LDSSQIEAEVDHILQSVDFD 373 >4YZB-A nrPDB Length = 491 Score = 318 bits (816), Expect = 3e-87, Method: Composition-based stats. Identities = 107/415 (25%), Positives = 194/415 (46%), Gaps = 43/415 (10%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 +Y+ R +G+G+F +V ++ TG A+K+++K + + + + +E+ ++K + H Sbjct: 30 DRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDKELLLKEVELLKKLDH 89 Query: 69 PNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCK 128 PNI++LYE Y+V E TGGELFD I+ + R E ++ + +Q++ + + H Sbjct: 90 PNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKN 149 Query: 129 GVYHRDLKPENLLLD---TNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQG 185 + HRDLKPENLLL+ + N+++ DFGLS E + ++ GT Y+APEVL G Sbjct: 150 KIVHRDLKPENLLLENKRKDANIRIIDFGLSTHF-ESTKKMKDKIGTAYYIAPEVLHGT- 207 Query: 186 YDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSC--PPW--FSAEVKFLI 241 D+WS GVIL+++L+G PF+ + + +K+ +F+ P W S K LI Sbjct: 208 -YDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQWKKVSEPAKDLI 266 Query: 242 HRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEVNLDDIRAVFDGIEGSYVAENVE 301 ++L P RI + + W + + D+ ++ I + + Sbjct: 267 RKMLAYVPTMRISARDALEHEWLKTTDAATDSI--------DVPSLESTILNIRQFQGTQ 318 Query: 302 RNDEGPLMMNAFEMITLSQGLNLSALFDRRQDFVKRQTRFVSRREPSEIIANIEAVANSM 361 + L+ ++ T + + L+ +F R Q + E++ + Sbjct: 319 KLAAAALLYMGSKLTTNEETVELNKIFQRMDKNGDGQL------DKQELMEGYVEL---- 368 Query: 362 GFKSHTRNFKTRLEGLSSIKAGQLAVVIEIYEVAPSLFMVDVRKAAGETLEYHKF 416 +L+G Q A+ E+ +V + VD K +EY +F Sbjct: 369 ----------MKLKGEDVSALDQSAIEFEVEQVLDA---VDFDKNG--FIEYSEF 408 >4CQG-A nrPDB Length = 331 Score = 316 bits (810), Expect = 1e-86, Method: Composition-based stats. Identities = 117/285 (41%), Positives = 177/285 (62%), Gaps = 4/285 (1%) Query: 1 MTKKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREI 60 M + YE+ TIG G FAKVK A + TG+ VAIKIM K+ + + + ++K EI Sbjct: 1 MKDYDELLKYYELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGSD--LPRVKTEI 58 Query: 61 SIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVD 120 +K +RH +I +LY VL + +KI++VLE+ GGELFD I+ + RL E E+R F+Q++ Sbjct: 59 DALKSLRHQHICQLYHVLETKNKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQILS 118 Query: 121 AVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVEL-LRTTCGTPNYVAPE 179 AVA+ H +G HRDLKPENLL D N LK+ DFGL A P+ + L+ CG+ Y APE Sbjct: 119 AVAYVHSQGYAHRDLKPENLLFDENHKLKLIDFGLCAKPKGNKDYHLQECCGSLAYAAPE 178 Query: 180 VLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKF 239 ++ G+ Y GS AD+WS G++L+V++ G+LPF + ++ LY+KI ++ P W S Sbjct: 179 LIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYEVPKWLSPSSIL 238 Query: 240 LIHRILDPNPKTRIQIQGIKKDPWFRLNYV-PIRAREEEEVNLDD 283 L+ ++L +PK RI ++ + PW +Y P+ + + + D Sbjct: 239 LLQQMLQVDPKKRISMRNLLNHPWVMQDYSCPVEWQSKTPLTHLD 283 >3Q5I-A nrPDB Length = 504 Score = 313 bits (802), Expect = 1e-85, Method: Composition-based stats. Identities = 94/348 (27%), Positives = 168/348 (48%), Gaps = 29/348 (8%) Query: 1 MTKKMRRVGK-YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNR-------- 51 + KK ++G+ Y R +G G + +V + + AIK++ KS K R Sbjct: 27 VRKKEGKIGESYFKVRKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYSDDNKNI 86 Query: 52 --MVDQIKREISIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEES 109 ++I EIS++K + HPNI++L++V Y+V EF GGELF++I+++ + +E Sbjct: 87 EKFHEEIYNEISLLKSLDHPNIIKLFDVFEDKKYFYLVTEFYEGGELFEQIINRHKFDEC 146 Query: 110 ESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNG---NLKVSDFGLSALPQEGVELL 166 ++ +Q++ + + H + HRD+KPEN+LL+ N+K+ DFGLS+ + L Sbjct: 147 DAANIMKQILSGICYLHKHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSFFSKD-YKL 205 Query: 167 RTTCGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAE 226 R GT Y+APEVL + D+WSCGVI++++L GY PF + + +K+ + Sbjct: 206 RDRLGTAYYIAPEVLKKK--YNEKCDVWSCGVIMYILLCGYPPFGGQNDQDIIKKVEKGK 263 Query: 227 FSCP----PWFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEVNLD 282 + S E K LI +L + R + W + I N Sbjct: 264 YYFDFNDWKNISDEAKELIKLMLTYDYNKRCTAEEALNSRWIKKYANNI--------NKS 315 Query: 283 DIRAVFDGIEGSYVAENVERNDEGPLMMNAFEMITLSQGLNLSALFDR 330 D + + + E ++ + ++ ++ TL + L+ +F + Sbjct: 316 DQKTLCGALSNMRKFEGSQKLAQAAILFIGSKLTTLEERKELTDIFKK 363 >4RGJ-A nrPDB Length = 520 Score = 313 bits (802), Expect = 1e-85, Method: Composition-based stats. Identities = 107/438 (24%), Positives = 210/438 (47%), Gaps = 46/438 (10%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 +Y+ + +G+G+F +V +R+ TG AIK+++K + + + + RE+ ++K++ H Sbjct: 60 EQYKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKESLLREVELLKMLDH 119 Query: 69 PNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCK 128 NI++LYE + Y+V + TGGELFD I+ + R E ++ + +Q++ + + H Sbjct: 120 INIMKLYEFFEDNNYYYLVSDVYTGGELFDEIISRKRFYEIDAARIIKQILSGITYMHKN 179 Query: 129 GVYHRDLKPENLLL----DTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQ 184 V HRDLKPEN+LL + +K+ DFGLS E + ++ GT Y+AP+VL G Sbjct: 180 NVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHF-EYSKKMKDKIGTAYYIAPDVLHGT 238 Query: 185 GYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCP----PWFSAEVKFL 240 DIWSCGVIL+++L+G PF+ ++ + +K+ A +++ S + K L Sbjct: 239 --YDEKCDIWSCGVILYILLSGCPPFNGSNEYDILKKVEAGKYTFDLPQFKKISDKAKDL 296 Query: 241 IHRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEVNLDDIRAVFDGIEGSYVAENV 300 I ++L RI + + W ++ DI ++ I ++ Sbjct: 297 IKKMLMYTSAVRISARDALEHEWIKMMTSKDNLNI-------DIPSLELSIANIRQFQST 349 Query: 301 ERNDEGPLMMNAFEMITLSQGLNLSALFDRRQDFVKRQTRFVSRREPSEIIANIEAVANS 360 ++ + L+ ++ T+ + L+ +F + Q + +E+I + + Sbjct: 350 QKLAQAALLYMGSKLTTIDETKELTKIFKKMDKNGDGQL------DRNELIIGYKEL--- 400 Query: 361 MGFKSHTRNFKTRLEGLSSIKAGQLAVVIEIYEVAPSLFMVDVRKAAGETLEYHKFYKKL 420 +L+G + A+ E+ ++ S +D+ + +EY +F L Sbjct: 401 -----------LKLKGEDTSDLDNAAIEYEVDQILNS---IDLDQNG--YIEYSEF---L 441 Query: 421 CSKLENIIWRATEGIPKS 438 ++ + +TE + K+ Sbjct: 442 TVSIDRKLLLSTERLEKA 459 >4D2V-A nrPDB Length = 356 Score = 313 bits (802), Expect = 1e-85, Method: Composition-based stats. Identities = 120/295 (40%), Positives = 176/295 (59%), Gaps = 5/295 (1%) Query: 1 MTKKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREI 60 M + YE+ TIG G FAKVK A + TG+ VAIKIM K+T+ + + +IK EI Sbjct: 21 MKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSD--LPRIKTEI 78 Query: 61 SIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVD 120 +K +RH +I +LY VL + +KI++VLE+ GGELFD I+ + RL E E+R F+Q+V Sbjct: 79 EALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVS 138 Query: 121 AVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVEL-LRTTCGTPNYVAPE 179 AVA+ H +G HRDLKPENLL D LK+ DFGL A P+ + L+ CG Y APE Sbjct: 139 AVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQACCGALAYAAPE 198 Query: 180 VLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKF 239 ++ G+ Y GS AD+WS G++L+V++ G+LPF + L KI ++ P W S Sbjct: 199 LIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDTAAALVAKIMRGKYDVPKWLSPSSIL 258 Query: 240 LIHRILDPNPKTRIQIQGIKKDPWFRLNYV-PIRAREEEE-VNLDDIRAVFDGIE 292 L+ ++L +PK RI ++ + PW +Y P+ + + ++LDD + Sbjct: 259 LLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVH 313 >5WAX-A nrPDB Length = 310 Score = 310 bits (795), Expect = 8e-85, Method: Composition-based stats. Identities = 117/306 (38%), Positives = 166/306 (54%), Gaps = 16/306 (5%) Query: 5 MRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMK 64 M +YE+ R IG G F + RN G VA+K + + + + ++REI + Sbjct: 7 MHDGDRYELVRDIGSGNFGVARLMRNRADGQLVAVKYIERGEKID----ENVQREIINHR 62 Query: 65 IVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAH 124 +RHPNI+R EV+ +P+ + IV+E+ +GGELF+RI + GR E E+R +FQQL+ V++ Sbjct: 63 SLRHPNIIRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSY 122 Query: 125 CHCKGVYHRDLKPENLLLD--TNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLS 182 CH V HRDLK EN LLD T LK+ DFG S + ++T GTP Y+APEVL Sbjct: 123 CHSMQVCHRDLKLENTLLDGSTAPRLKICDFGYSKSSVLHSQP-KSTVGTPAYIAPEVLL 181 Query: 183 GQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRK----INAAEFSCPP--WFSAE 236 + YDG AD+WSCGV L+V+L G PF + D P +RK I ++S P S E Sbjct: 182 KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILGVQYSIPDYVHISPE 241 Query: 237 VKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEE--EVNLDDIRAVFDGIEGS 294 + LI RI NP TRI I I+ PWF N +P ++ ++ ++ Sbjct: 242 CQDLISRIFVANPATRITIPEIRNHPWFLKN-LPADLMDDSTMSKQYEEPEQPMQSMDEI 300 Query: 295 YVAENV 300 Sbjct: 301 MQILAE 306 >2HAK-A nrPDB Length = 328 Score = 309 bits (793), Expect = 1e-84, Method: Composition-based stats. Identities = 116/283 (40%), Positives = 176/283 (62%), Gaps = 5/283 (1%) Query: 2 TKKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREIS 61 T + +G Y + +TIG+G FAKVK AR+ TG VA+KI+ K T L + ++ RE+ Sbjct: 8 TDEQPHIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDK-TQLNPTSLQKLFREVR 66 Query: 62 IMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDA 121 IMKI+ HPNIV+L+EV+ + +Y+V+E+ +GGE+FD +V GR++E E+R F+Q+V A Sbjct: 67 IMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSA 126 Query: 122 VAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVL 181 V +CH K + HRDLK ENLLLD + N+K++DFG S G + L T CG+P Y APE+ Sbjct: 127 VQYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNK-LDTFCGSPPYAAPELF 185 Query: 182 SGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLI 241 G+ YDG D+WS GVIL+ +++G LPF +L L ++ ++ P + S + + L+ Sbjct: 186 QGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLL 245 Query: 242 HRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEVNLDDI 284 ++L NP R ++ I KD W + + E + D Sbjct: 246 KKLLVLNPIKRGSLEQIMKDRWMNVGH---EEEELKPYTEPDP 285 >6C9D-A nrPDB Length = 459 Score = 308 bits (790), Expect = 2e-84, Method: Composition-based stats. Identities = 140/451 (31%), Positives = 240/451 (53%), Gaps = 33/451 (7%) Query: 2 TKKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREIS 61 T + +G Y + +TIG+G FAKVK AR+ TG VA+KI+ K T L + ++ RE+ Sbjct: 14 TDEQPHIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDK-TQLNPTSLQKLFREVR 72 Query: 62 IMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDA 121 IMKI+ HPNIV+L+EV+ + +Y+V+E+ +GGE+FD +V GR++E E+R F+Q+V A Sbjct: 73 IMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSA 132 Query: 122 VAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVL 181 V +CH K + HRDLK ENLLLD + N+K++DFG S G + L CG+P Y APE+ Sbjct: 133 VQYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNK-LDEFCGSPPYAAPELF 191 Query: 182 SGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLI 241 G+ YDG D+WS GVIL+ +++G LPF +L L ++ ++ P + S + + L+ Sbjct: 192 QGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLL 251 Query: 242 HRILDPNPKTRIQIQGIKKDPWFRLNY--VPIRAREEEEVNLDDIRAVFDGIEGSY---- 295 ++L NP R ++ I KD W + + ++ E + + +D + + + + Sbjct: 252 KKLLVLNPIKRGSLEQIMKDRWMNVGHEEEELKPYTEPDPDFNDTKRIDIMVTMGFARDE 311 Query: 296 --VAENVERNDEGPLMMNAFEMITLSQ-----GLNLSALFDRR-----QDFVKRQTRF-- 341 A ++ DE +M + ++ G +LS R +D R RF Sbjct: 312 INDALINQKYDE---VMATYILLGRKPPEFEGGESLSGEPKERDKEEGKDSKPRSLRFTW 368 Query: 342 ----VSRREPSEIIANIEAVANSMGFK-SHTRNFKTRLEGLSSIKAGQLAVVIEIYEVAP 396 S +P++++ I V ++ F + + + +E+ + P Sbjct: 369 SMKTTSSMDPNDMMREIRKVLDANNCDYEQKERFLLFCVHGDARQDSLVQWEMEVCSL-P 427 Query: 397 SLFM--VDVRKAAGETLEYHKFYKKLCSKLE 425 SL + V ++ +G ++ + K+ ++L+ Sbjct: 428 SLSLNGVRFKRISGTSIAFKNIASKIANELK 458 >5F9E-A nrPDB Length = 353 Score = 306 bits (784), Expect = 1e-83, Method: Composition-based stats. Identities = 83/298 (27%), Positives = 152/298 (51%), Gaps = 4/298 (1%) Query: 7 RVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIV 66 ++ +E+ + +G+G+F KV A T AIK + K +L + V+ E ++ + Sbjct: 17 KIEDFELHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLA 76 Query: 67 -RHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHC 125 HP + ++ + ++ V+E++ GG+L I + + S + Y +++ + Sbjct: 77 WEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFL 136 Query: 126 HCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQG 185 H KG+ +RDLK +N+LLD +G++K++DFG+ G CGTP+Y+APE+L GQ Sbjct: 137 HSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNEFCGTPDYIAPEILLGQK 196 Query: 186 YDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRIL 245 Y+ + D WS GV+L+ +L G PF D L+ I P W E K L+ ++ Sbjct: 197 YN-HSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEKEAKDLLVKLF 255 Query: 246 DPNPKTRIQIQ-GIKKDPWFR-LNYVPIRAREEEEVNLDDIRAVFDGIEGSYVAENVE 301 P+ R+ ++ I++ P FR +N+ + +E + +++ FD N + Sbjct: 256 VREPEKRLGVRGDIRQHPLFREINWEELERKEIDPPFRPKVKSPFDCSNFDKEFLNEK 313 >2VN9-A nrPDB Length = 301 Score = 306 bits (783), Expect = 2e-83, Method: Composition-based stats. Identities = 100/263 (38%), Positives = 152/263 (57%), Gaps = 9/263 (3%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 +Y++ +G+G F+ V+ TG A KI+ L R +++RE I ++++H Sbjct: 4 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKK-LSARDHQKLEREARICRLLKH 62 Query: 69 PNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCK 128 PNIVRL++ ++ Y+V + VTGGELF+ IV + E+++ QQ++++V HCH Sbjct: 63 PNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLN 122 Query: 129 GVYHRDLKPENLLLDTNGN---LKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQG 185 G+ HRDLKPENLLL + +K++DFGL+ Q + GTP Y++PEVL Sbjct: 123 GIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDP 182 Query: 186 YDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAA--EFSCPPW--FSAEVKFLI 241 Y G D+W+CGVIL+++L GY PF + D LY++I A +F P W + E K LI Sbjct: 183 Y-GKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLI 241 Query: 242 HRILDPNPKTRIQIQGIKKDPWF 264 +++L NP RI K PW Sbjct: 242 NKMLTINPAKRITASEALKHPWI 264 >3MA6-A nrPDB Length = 298 Score = 305 bits (781), Expect = 3e-83, Method: Composition-based stats. Identities = 86/264 (32%), Positives = 145/264 (54%), Gaps = 10/264 (3%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 +Y+ R +G+G+F +V ++ TG A+K+++K + + + + RE+ ++K + H Sbjct: 32 DRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDH 91 Query: 69 PNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCK 128 PNI++LYE Y+V E TGGELFD I+ + R E ++ + +Q++ + + H Sbjct: 92 PNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKN 151 Query: 129 GVYHRDLKPENLLL---DTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQG 185 + HRDLKPENLLL + N+++ DFGLS E + ++ GT Y+APEVL G Sbjct: 152 KIVHRDLKPENLLLESKSKDANIRIIDFGLSTHF-EASKKMKDKIGTAYYIAPEVLHGT- 209 Query: 186 YDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSC--PPW--FSAEVKFLI 241 D+WS GVIL+++L+G PF+ + + +K+ +++ P W S K LI Sbjct: 210 -YDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFELPQWKKVSESAKDLI 268 Query: 242 HRILDPNPKTRIQIQGIKKDPWFR 265 ++L P RI + W + Sbjct: 269 RKMLTYVPSMRISARDALDHEWIQ 292 >4MVF-A nrPDB Length = 506 Score = 305 bits (781), Expect = 3e-83, Method: Composition-based stats. Identities = 97/297 (32%), Positives = 143/297 (48%), Gaps = 13/297 (4%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 KY + +G+GT+ V + T AIK K + + +++ +EI IMK + H Sbjct: 57 DKYIIDEKLGQGTYGCVYKGIDKVTNQLYAIKEEKKDRL---KNINRFFQEIEIMKKLDH 113 Query: 69 PNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCK 128 PNIV+LYE + + IY+++E +G ELFD I+ G E + +Q+ A+ + H Sbjct: 114 PNIVKLYETYENDNYIYLIMELCSGRELFDSIIENGSFTEKNAATIMKQIFSAIFYLHSL 173 Query: 129 GVYHRDLKPENLLL---DTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQG 185 + HRDLKPEN L + + LK+ DFGLS G E T GTP YVAP+VL G+ Sbjct: 174 NIVHRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTG-EFTTTKAGTPYYVAPQVLDGK- 231 Query: 186 YDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPP----WFSAEVKFLI 241 DIWS GVI++ +L GY PF + +K+ EF S++ K LI Sbjct: 232 -YDKKCDIWSSGVIMYTLLCGYPPFYGDTDNEVLKKVKKGEFCFYENDWGSISSDAKNLI 290 Query: 242 HRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEVNLDDIRAVFDGIEGSYVAE 298 ++L NP R I+ PW E L +++ E +A Sbjct: 291 TKLLTYNPNERCTIEEALNHPWITQMTKSHEHVELSSTLLKNLKNFKKENELKKIAL 347 >3TXO-A nrPDB Length = 353 Score = 305 bits (781), Expect = 3e-83, Method: Composition-based stats. Identities = 92/302 (30%), Positives = 155/302 (51%), Gaps = 9/302 (2%) Query: 8 VGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR 67 + +E R +G+G+F KV AR +TGD A+K++ K IL++ V+ E I+ + R Sbjct: 22 IDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLAR 81 Query: 68 -HPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCH 126 HP + +L+ +P +++ V+EFV GG+L I R +E+ +R Y +++ A+ H Sbjct: 82 NHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLH 141 Query: 127 CKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGY 186 KG+ +RDLK +N+LLD G+ K++DFG+ T CGTP+Y+APE+L Y Sbjct: 142 DKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLY 201 Query: 187 DGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILD 246 G A D W+ GV+L+ +L G+ PF + L+ I E P W + ++ + Sbjct: 202 -GPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMT 260 Query: 247 PNPKTRIQI------QGIKKDPWFR-LNYVPIRAREEEEVNLDDIRAVFDGIEGSYVAEN 299 NP R+ I + P+F+ +++ + R+ E I++ D Sbjct: 261 KNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIK 320 Query: 300 VE 301 E Sbjct: 321 EE 322 >5FG8-A nrPDB Length = 285 Score = 305 bits (781), Expect = 3e-83, Method: Composition-based stats. Identities = 103/270 (38%), Positives = 151/270 (55%), Gaps = 9/270 (3%) Query: 2 TKKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREIS 61 R Y++ +G+G F+ VK TG A KI+ L R +++RE Sbjct: 7 AACTRFSDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKK-LTARDFQKLEREAR 65 Query: 62 IMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDA 121 I + + HPNIVRL++ + + Y+V + VTGGELF+ IV + E+++ QQ++++ Sbjct: 66 ICRKLHHPNIVRLHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILES 125 Query: 122 VAHCHCKGVYHRDLKPENLLLDTNGN---LKVSDFGLSALPQEGVELLRTTCGTPNYVAP 178 V HCH GV HRDLKPENLLL + +K++DFGL+ Q + GTP Y++P Sbjct: 126 VNHCHQNGVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSP 185 Query: 179 EVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAA--EFSCPPW--FS 234 EVL + Y G + DIW+CGVIL+++L GY PF + D LY +I A ++ P W + Sbjct: 186 EVLKKEPY-GKSVDIWACGVILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVT 244 Query: 235 AEVKFLIHRILDPNPKTRIQIQGIKKDPWF 264 E K LI+++L NP RI K PW Sbjct: 245 PEAKNLINQMLTVNPNKRITAAEALKHPWI 274 >5YKS-A nrPDB Length = 377 Score = 304 bits (780), Expect = 4e-83, Method: Composition-based stats. Identities = 110/262 (41%), Positives = 163/262 (62%), Gaps = 4/262 (1%) Query: 6 RRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKI 65 + G Y++ +T+G G FA VK AR+ TG+ VA+K++ K+ L + +E+ MK+ Sbjct: 32 KIAGLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTK-LDTLATGHLFQEVRCMKL 90 Query: 66 VRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRI-VHKGRLEESESRKYFQQLVDAVAH 124 V+HPNIVRLYEV+ + +K+Y++LE GG++FD I H+ L E ++KYF Q+V A+++ Sbjct: 91 VQHPNIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISY 150 Query: 125 CHCKGVYHRDLKPENL-LLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSG 183 CH V HRDLKPEN+ + G +K++DFG S Q G + L T+CG+ Y APE+L G Sbjct: 151 CHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPG-KKLTTSCGSLAYSAPEILLG 209 Query: 184 QGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHR 243 YD A DIWS GVILF+++ G PF E + I +++ P S E K LI R Sbjct: 210 DEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITR 269 Query: 244 ILDPNPKTRIQIQGIKKDPWFR 265 +L +PK R ++ I+ PW + Sbjct: 270 MLQRDPKRRASLEEIENHPWLQ 291 >2V7O-A nrPDB Length = 336 Score = 304 bits (779), Expect = 6e-83, Method: Composition-based stats. Identities = 98/271 (36%), Positives = 148/271 (54%), Gaps = 9/271 (3%) Query: 1 MTKKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREI 60 M R Y++ +G+G F+ V+ A KI+ L R +++RE Sbjct: 23 MATCTRFTDDYQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKK-LSARDHQKLEREA 81 Query: 61 SIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVD 120 I ++++HPNIVRL++ ++ Y+V + VTGGELF+ IV + E+++ Q+++ Sbjct: 82 RICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILE 141 Query: 121 AVAHCHCKGVYHRDLKPENLLLDTNGN---LKVSDFGLSALPQEGVELLRTTCGTPNYVA 177 +V H H + HRDLKPENLLL + +K++DFGL+ Q + GTP Y++ Sbjct: 142 SVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLS 201 Query: 178 PEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAA--EFSCPPW--F 233 PEVL Y G DIW+CGVIL+++L GY PF + D LY++I A +F P W Sbjct: 202 PEVLRKDPY-GKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTV 260 Query: 234 SAEVKFLIHRILDPNPKTRIQIQGIKKDPWF 264 + E K LI+++L NP RI K PW Sbjct: 261 TPEAKNLINQMLTINPAKRITADQALKHPWV 291 >2JDO-A nrPDB Length = 342 Score = 303 bits (776), Expect = 1e-82, Method: Composition-based stats. Identities = 90/329 (27%), Positives = 154/329 (46%), Gaps = 8/329 (2%) Query: 8 VGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR 67 + ++ + +G+GTF KV R TG A+KI+ K I+ V E +++ R Sbjct: 9 MNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTR 68 Query: 68 HPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHC 127 HP + L + ++ V+E+ GGELF + + E +R Y ++V A+ + H Sbjct: 69 HPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHS 128 Query: 128 KGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYD 187 + V +RD+K ENL+LD +G++K++DFGL ++T CGTP Y+APEVL Y Sbjct: 129 RDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDY- 187 Query: 188 GSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILDP 247 G A D W GV+++ ++ G LPF D L+ I E P S E K L+ +L Sbjct: 188 GRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKK 247 Query: 248 NPKTRI-----QIQGIKKDPWF-RLNYVPIRAREEEEVNLDDIRAVFDGIEGSYVAENVE 301 +PK R+ + + + +F +N+ + ++ + + D Sbjct: 248 DPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQS 307 Query: 302 RNDEGPLMMNAFEMITLSQGLNLSALFDR 330 P ++ ++ L Q +F+ Sbjct: 308 ITITPPDRYDSLGLLELDQ-REEQEMFED 335 >4YNZ-A nrPDB Length = 342 Score = 303 bits (776), Expect = 1e-82, Method: Composition-based stats. Identities = 112/283 (39%), Positives = 178/283 (62%), Gaps = 8/283 (2%) Query: 5 MRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMK 64 M+ VG Y + +T+G+G VK + T VAIKI+ + L ++ +++REI+I+K Sbjct: 6 MQYVGPYRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREK-LSESVLMKVEREIAILK 64 Query: 65 IVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAH 124 ++ HP++++L++V + +Y+VLE V+GGELFD +V KGRL E+RK+F+Q++ A+ Sbjct: 65 LIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDF 124 Query: 125 CHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQ 184 CH + HRDLKPENLLLD N++++DFG+++L Q G LL T+CG+P+Y PEV+ G+ Sbjct: 125 CHSHSICHRDLKPENLLLDERNNIRIADFGMASL-QVGDSLLETSCGSPHYACPEVIRGE 183 Query: 185 GYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRI 244 YDG AD+WSCGVILF +L G LPF + +L L K+ F P + + + L+ + Sbjct: 184 KYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGM 243 Query: 245 LDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEVNLDDIRAV 287 ++ + R+ ++ I+K W+ I + E E R V Sbjct: 244 IEVDAARRLTLEHIQKHIWY------IGGKNEPEPEQPIPRKV 280 >4B6L-A nrPDB Length = 281 Score = 303 bits (776), Expect = 1e-82, Method: Composition-based stats. Identities = 97/278 (34%), Positives = 144/278 (51%), Gaps = 2/278 (0%) Query: 6 RRVGK-YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMK 64 R G+ Y GR +G+G FA+ A +T+TG A+K++ +S + K ++I EI + + Sbjct: 5 PRSGRTYLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHR 64 Query: 65 IVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAH 124 ++H +IVR IYI LE + L + L E E R Y +Q++ + + Sbjct: 65 DLQHRHIVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKY 124 Query: 125 CHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQ 184 H +G+ HRDLK N + N LKV DFGL+A + + +T CGTPNYVAPEVL Q Sbjct: 125 LHQRGILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQ 184 Query: 185 GYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRI 244 G+ G AD+WS G +++ +L G PF DL YR I ++ P S + L+ I Sbjct: 185 GH-GPEADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAI 243 Query: 245 LDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEVNLD 282 L +P+ R I I + +F Y P R V + Sbjct: 244 LRASPRDRPSIDQILRHDFFTKGYTPDRLPISSCVTVP 281 >5IG1-A nrPDB Length = 344 Score = 303 bits (776), Expect = 1e-82, Method: Composition-based stats. Identities = 104/282 (36%), Positives = 156/282 (55%), Gaps = 15/282 (5%) Query: 1 MTKKMRRVGKYEVG-----RTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQ 55 M + Y+V IG+G F+ V N TG+ A+K++A ++ + +++ Sbjct: 4 METETSFFDLYDVDLKDKRSVIGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRSSE-INK 62 Query: 56 IKREISIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYF 115 IKREI I ++H +IV + S Y+V E+V+GGELFD IV + E ++ Sbjct: 63 IKREIGICSSLQHEHIVSMRRAFRDESHFYLVFEYVSGGELFDEIVTRKFYNEKDASACM 122 Query: 116 QQLVDAVAHCHCKGVYHRDLKPENLLL---DTNGNLKVSDFGLSALPQEGVELLRTTCGT 172 Q++ A+ HCH K + HRDLKPENLLL D N +K++DFGL+ + ++G GT Sbjct: 123 HQILSALQHCHSKNIIHRDLKPENLLLASKDPNAPVKITDFGLAVIMEQGPTYF-GFAGT 181 Query: 173 PNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCP-- 230 P Y++PEV+ YD A D+W+CGVIL+++L GY PF E D LY +I ++ P Sbjct: 182 PGYLSPEVIRRVPYDT-AVDVWACGVILYILLVGYPPFWEEDHQKLYAQIKNCQYDFPSP 240 Query: 231 --PWFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVP 270 + K LI +L+PNPK R +Q + + PW VP Sbjct: 241 EWDSVTTAAKELIKAMLEPNPKRRPTVQELLQHPWIARRDVP 282 >3DFA-A nrPDB Length = 286 Score = 302 bits (774), Expect = 2e-82, Method: Composition-based stats. Identities = 88/266 (33%), Positives = 151/266 (56%), Gaps = 11/266 (4%) Query: 8 VGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR 67 +Y + +G+G+F +V ++ T A+K++ K++ KN+ I RE+ ++K + Sbjct: 21 AERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASA-KNKDTSTILREVELLKKLD 79 Query: 68 HPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHC 127 HPNI++L+E+L S YIV E TGGELFD I+ + R E ++ + +Q+ + + H Sbjct: 80 HPNIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMHK 139 Query: 128 KGVYHRDLKPENLLLDT---NGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQ 184 + HRDLKPEN+LL++ + ++K+ DFGLS Q+ + ++ GT Y+APEVL G Sbjct: 140 HNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTK-MKDRIGTAYYIAPEVLRGT 198 Query: 185 GYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSC--PPW--FSAEVKFL 240 D+WS GVIL+++L+G PF + + +++ +++ P W S + K L Sbjct: 199 --YDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRVETGKYAFDLPQWRTISDDAKDL 256 Query: 241 IHRILDPNPKTRIQIQGIKKDPWFRL 266 I ++L +P RI + PW + Sbjct: 257 IRKMLTFHPSLRITATQCLEHPWIQK 282 >3DXN-A nrPDB Length = 287 Score = 302 bits (774), Expect = 2e-82, Method: Composition-based stats. Identities = 87/263 (33%), Positives = 141/263 (53%), Gaps = 10/263 (3%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 +Y+ + +G G + +V ++ TG AIKI+ KS++ + E++++K + H Sbjct: 21 DRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDH 80 Query: 69 PNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCK 128 PNI++LYE Y+V+E GGELFD I+ + + E ++ +Q++ + H Sbjct: 81 PNIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSGTTYLHKH 140 Query: 129 GVYHRDLKPENLLLDT---NGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQG 185 + HRDLKPENLLL++ + +K+ DFGLSA + G + ++ GT Y+APEVL + Sbjct: 141 NIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGK-MKERLGTAYYIAPEVLRKK- 198 Query: 186 YDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPP----WFSAEVKFLI 241 D+WSCGVIL+++L GY PF + +++ +FS P S E K L+ Sbjct: 199 -YDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKGKFSFDPPDWTQVSDEAKQLV 257 Query: 242 HRILDPNPKTRIQIQGIKKDPWF 264 +L P RI + PW Sbjct: 258 KLMLTYEPSKRISAEEALNHPWI 280 >1FOT-A nrPDB Length = 318 Score = 302 bits (773), Expect = 2e-82, Method: Composition-based stats. Identities = 88/282 (31%), Positives = 163/282 (57%), Gaps = 10/282 (3%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 +++ RT+G G+F +V R+ G A+K++ K +++ + V+ E ++ IV HP Sbjct: 7 DFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTHP 66 Query: 70 NIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKG 129 I+R++ +I+++++++ GGELF + R ++ Y ++ A+ + H K Sbjct: 67 FIIRMWGTFQDAQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLHSKD 126 Query: 130 VYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGS 189 + +RDLKPEN+LLD NG++K++DFG + + + T CGTP+Y+APEV+S + Y+ Sbjct: 127 IIYRDLKPENILLDKNGHIKITDFGFAKYVPD---VTYTLCGTPDYIAPEVVSTKPYN-K 182 Query: 190 AADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILDPNP 249 + D WS G++++ +LAGY PF +++ Y KI AE PP+F+ +VK L+ R++ + Sbjct: 183 SIDWWSFGILIYEMLAGYTPFYDSNTMKTYEKILNAELRFPPFFNEDVKDLLSRLITRDL 242 Query: 250 KTRI-----QIQGIKKDPWFR-LNYVPIRAREEEEVNLDDIR 285 R+ + +K PWF+ + + + +R E I+ Sbjct: 243 SQRLGNLQNGTEDVKNHPWFKEVVWEKLLSRNIETPYEPPIQ 284 >4L42-A nrPDB Length = 346 Score = 301 bits (772), Expect = 3e-82, Method: Composition-based stats. Identities = 91/293 (31%), Positives = 162/293 (55%), Gaps = 11/293 (3%) Query: 7 RVGKYEVGRTIGEGTFAKVKFARNT---DTGDNVAIKIMAKSTILKN-RMVDQIKREISI 62 R +E+ R +G+G + KV R +TG A+K++ K+ I++N + K E +I Sbjct: 16 RPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNI 75 Query: 63 MKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAV 122 ++ V+HP IV L + K+Y++LE+++GGELF ++ +G E + Y ++ A+ Sbjct: 76 LEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMAL 135 Query: 123 AHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLS 182 H H KG+ +RDLKPEN++L+ G++K++DFGL + T CGT Y+APE+L Sbjct: 136 GHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILM 195 Query: 183 GQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIH 242 G++ A D WS G +++ +L G PF+ + KI + + PP+ + E + L+ Sbjct: 196 RSGHN-RAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLK 254 Query: 243 RILDPNPKTRI-----QIQGIKKDPWFR-LNYVPIRAREEEEVNLDDIRAVFD 289 ++L N +R+ ++ P+FR +N+ + AR+ E +++ D Sbjct: 255 KLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEED 307 >5U6Y-A nrPDB Length = 461 Score = 300 bits (769), Expect = 8e-82, Method: Composition-based stats. Identities = 99/261 (37%), Positives = 150/261 (57%), Gaps = 9/261 (3%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 Y++ +G+G F+ V+ G A KI+ L R +++RE I ++++HPN Sbjct: 2 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKK-LSARDHQKLEREARICRLLKHPN 60 Query: 71 IVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGV 130 IVRL++ ++ Y++ + VTGGELF+ IV + E+++ QQ+++AV HCH GV Sbjct: 61 IVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGV 120 Query: 131 YHRDLKPENLLLDTNGN---LKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYD 187 HRDLKPENLLL + +K++DFGL+ + + GTP Y++PEVL Y Sbjct: 121 VHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPY- 179 Query: 188 GSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAA--EFSCPPW--FSAEVKFLIHR 243 G D+W+CGVIL+++L GY PF + D LY++I A +F P W + E K LI++ Sbjct: 180 GKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINK 239 Query: 244 ILDPNPKTRIQIQGIKKDPWF 264 +L NP RI K PW Sbjct: 240 MLTINPSKRITAAEALKHPWI 260 >5N23-A nrPDB Length = 352 Score = 300 bits (769), Expect = 8e-82, Method: Composition-based stats. Identities = 94/307 (30%), Positives = 157/307 (51%), Gaps = 9/307 (2%) Query: 2 TKKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREIS 61 + + ++E RT+G G+F +V ++ +TG++ A+KI+ K ++K + ++ E Sbjct: 35 AQNTAHLDQFERIRTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKR 94 Query: 62 IMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDA 121 I + V P +V+L S +Y+VLE+ GGE+F + GR E +R Y Q+V Sbjct: 95 IQQAVNFPFLVKLEFSFKDNSNLYMVLEYAPGGEMFSHLRRIGRFSEPHARFYAAQIVLT 154 Query: 122 VAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVL 181 + H + +RDLKPENLL+D G +KV+DFG + + T CGTP Y+APE++ Sbjct: 155 FEYLHSLDLIYRDLKPENLLIDQQGYIKVADFGFAKRVKG--RTPWTLCGTPEYLAPEII 212 Query: 182 SGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLI 241 +GY+ A D W+ GV+++ + AGY PF +Y KI + + P FS+++K L+ Sbjct: 213 LSKGYN-KAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLL 271 Query: 242 HRILDPNPKTRI-----QIQGIKKDPWF-RLNYVPIRAREEEEVNLDDIRAVFDGIEGSY 295 +L + R + IK WF +++ I R+ E + + D Sbjct: 272 RNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDD 331 Query: 296 VAENVER 302 E R Sbjct: 332 YEEEEIR 338 >2VZ6-A nrPDB Length = 313 Score = 300 bits (768), Expect = 8e-82, Method: Composition-based stats. Identities = 99/261 (37%), Positives = 150/261 (57%), Gaps = 9/261 (3%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 Y++ +G+G F+ V+ G A KI+ L R +++RE I ++++HPN Sbjct: 24 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKK-LSARDHQKLEREARICRLLKHPN 82 Query: 71 IVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGV 130 IVRL++ ++ Y++ + VTGGELF+ IV + E+++ QQ+++AV HCH GV Sbjct: 83 IVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGV 142 Query: 131 YHRDLKPENLLLDTNGN---LKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYD 187 HRDLKPENLLL + +K++DFGL+ + + GTP Y++PEVL Y Sbjct: 143 VHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPY- 201 Query: 188 GSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAA--EFSCPPW--FSAEVKFLIHR 243 G D+W+CGVIL+++L GY PF + D LY++I A +F P W + E K LI++ Sbjct: 202 GKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINK 261 Query: 244 ILDPNPKTRIQIQGIKKDPWF 264 +L NP RI K PW Sbjct: 262 MLTINPSKRITAAEALKHPWI 282 >3BHH-A nrPDB Length = 295 Score = 300 bits (768), Expect = 9e-82, Method: Composition-based stats. Identities = 103/263 (39%), Positives = 152/263 (57%), Gaps = 9/263 (3%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 +Y++ IG+G F+ V+ TG A KI+ L R +++RE I ++++H Sbjct: 4 DEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKK-LSARDHQKLEREARICRLLKH 62 Query: 69 PNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCK 128 NIVRL++ ++ Y+V + VTGGELF+ IV + E+++ QQ+++AV HCH Sbjct: 63 SNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQM 122 Query: 129 GVYHRDLKPENLLLDTNGN---LKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQG 185 GV HRDLKPENLLL + +K++DFGL+ Q + GTP Y++PEVL + Sbjct: 123 GVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEA 182 Query: 186 YDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAA--EFSCPPW--FSAEVKFLI 241 Y G DIW+CGVIL+++L GY PF + D LY++I A +F P W + E K LI Sbjct: 183 Y-GKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLI 241 Query: 242 HRILDPNPKTRIQIQGIKKDPWF 264 +++L NP RI K PW Sbjct: 242 NQMLTINPAKRITAHEALKHPWV 264 >5X3F-B nrPDB Length = 393 Score = 300 bits (768), Expect = 9e-82, Method: Composition-based stats. Identities = 90/307 (29%), Positives = 161/307 (52%), Gaps = 10/307 (3%) Query: 2 TKKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREIS 61 ++ ++ +++ +T+G G+F +V ++ ++G++ A+KI+ K ++K + ++ E Sbjct: 77 SQNTAQLDQFDRIKTLGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIEHTLNEKR 136 Query: 62 IMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDA 121 I++ V P +V+L S +Y+V+E+V GGE+F + GR E +R Y Q+V Sbjct: 137 ILQAVNFPFLVKLEFSFKDNSNLYMVMEYVAGGEMFSHLRRIGRFSEPHARFYAAQIVLT 196 Query: 122 VAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVL 181 + H + +RDLKPENLL+D G ++V+DFG + + T CGTP Y+APE++ Sbjct: 197 FEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG---RTWTLCGTPEYLAPEII 253 Query: 182 SGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLI 241 +GY+ A D W+ GV+++ + AGY PF +Y KI + + P FS+++K L+ Sbjct: 254 LSKGYN-KAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLL 312 Query: 242 HRILDPNPKTRI-----QIQGIKKDPWF-RLNYVPIRAREEEEVNLDDIRAVFDGIEGSY 295 +L + R + IK WF +++ I R+ E + + D Sbjct: 313 RNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDD 372 Query: 296 VAENVER 302 E R Sbjct: 373 YEEEEIR 379 >3ZUT-A nrPDB Length = 362 Score = 300 bits (768), Expect = 9e-82, Method: Composition-based stats. Identities = 111/305 (36%), Positives = 161/305 (52%), Gaps = 14/305 (4%) Query: 5 MRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMK 64 M +YE+ + IG G F + R+ + + VA+K + + + + +KREI + Sbjct: 15 MHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKID----ENVKREIINHR 70 Query: 65 IVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAH 124 +RHPNIVR EV+ +P+ + IV+E+ +GGELF+RI + GR E E+R +FQQL+ V++ Sbjct: 71 SLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSY 130 Query: 125 CHCKGVYHRDLKPENLLLDTN--GNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLS 182 CH V HRDLK EN LLD + LK+ FG S + ++T GTP Y+APEVL Sbjct: 131 CHAMQVCHRDLKLENTLLDGSPAPRLKICAFGYSKSSVLHSQP-KSTVGTPAYIAPEVLL 189 Query: 183 GQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRK----INAAEFSCPP--WFSAE 236 + YDG AD+WSCGV L+V+L G PF + + P +RK I +++ P S E Sbjct: 190 KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPE 249 Query: 237 VKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEE-EVNLDDIRAVFDGIEGSY 295 + LI RI +P RI I I+ WF N + D+ IE Sbjct: 250 CRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQFDESDQPGQSIEEIM 309 Query: 296 VAENV 300 Sbjct: 310 QIIAE 314 >4UZD-A nrPDB Length = 287 Score = 299 bits (767), Expect = 1e-81, Method: Composition-based stats. Identities = 88/266 (33%), Positives = 149/266 (56%), Gaps = 3/266 (1%) Query: 2 TKKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREIS 61 K+ + +E+GR +G+G F V AR + +A+K++ K+ + K + Q++RE+ Sbjct: 1 MKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVE 60 Query: 62 IMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDA 121 I +RHPNI+RLY +++Y++LE+ G ++ + + +E + Y +L +A Sbjct: 61 IQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANA 120 Query: 122 VAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVL 181 +++CH K V HRD+KPENLLL + G LK++DFG S T CGT +Y+ PE++ Sbjct: 121 LSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWS--VHAPSSRRTTLCGTLDYLPPEMI 178 Query: 182 SGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLI 241 G+ +D D+WS GV+ + L G PF Y++I+ EF+ P + + + LI Sbjct: 179 EGRMHD-EKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLI 237 Query: 242 HRILDPNPKTRIQIQGIKKDPWFRLN 267 R+L NP R ++ + + PW N Sbjct: 238 SRLLKHNPSQRPMLREVLEHPWITAN 263 >2BDW-A nrPDB Length = 362 Score = 299 bits (767), Expect = 1e-81, Method: Composition-based stats. Identities = 101/271 (37%), Positives = 151/271 (55%), Gaps = 10/271 (3%) Query: 1 MTKKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREI 60 M + Y+V +G+G F+ V+ + TG A KI+ L R +++RE Sbjct: 21 MNASTKFSDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKK-LSARDFQKLEREA 79 Query: 61 SIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVD 120 I + ++HPNIVRL++ + S Y+V + VTGGELF+ IV + E+++ QQ+++ Sbjct: 80 RICRKLQHPNIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILE 139 Query: 121 AVAHCHCKGVYHRDLKPENLLLDTNGN---LKVSDFGLSALPQEGVELLRTTCGTPNYVA 177 ++A+CH G+ HR+LKPENLLL + +K++DFGL+ + E GTP Y++ Sbjct: 140 SIAYCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDS-EAWHGFAGTPGYLS 198 Query: 178 PEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAA--EFSCPPW--F 233 PEVL Y DIW+CGVIL+++L GY PF + D LY +I A ++ P W Sbjct: 199 PEVLKKDPY-SKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYDYPSPEWDTV 257 Query: 234 SAEVKFLIHRILDPNPKTRIQIQGIKKDPWF 264 + E K LI +L NPK RI K PW Sbjct: 258 TPEAKSLIDSMLTVNPKKRITADQALKVPWI 288 >3UC3-A nrPDB Length = 361 Score = 299 bits (767), Expect = 1e-81, Method: Composition-based stats. Identities = 110/271 (40%), Positives = 157/271 (57%), Gaps = 13/271 (4%) Query: 5 MRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMK 64 M +Y+ + IG G F + R+ T + VA+K + + + + ++REI + Sbjct: 16 MHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGAAID----ENVQREIINHR 71 Query: 65 IVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAH 124 +RHPNIVR EV+ +P+ + I++E+ +GGEL++RI + GR E E+R +FQQL+ V++ Sbjct: 72 SLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSY 131 Query: 125 CHCKGVYHRDLKPENLLLDTN--GNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLS 182 CH + HRDLK EN LLD + LK+ DFG S + ++T GTP Y+APEVL Sbjct: 132 CHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQP-KSTVGTPAYIAPEVLL 190 Query: 183 GQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRK----INAAEFSCPP--WFSAE 236 Q YDG AD+WSCGV L+V+L G PF + + P YRK I + ++S P S E Sbjct: 191 RQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPE 250 Query: 237 VKFLIHRILDPNPKTRIQIQGIKKDPWFRLN 267 LI RI +P TRI I IK WF N Sbjct: 251 CCHLISRIFVADPATRISIPEIKTHSWFLKN 281 >4RLP-A nrPDB Length = 288 Score = 299 bits (767), Expect = 1e-81, Method: Composition-based stats. Identities = 90/286 (31%), Positives = 158/286 (55%), Gaps = 11/286 (3%) Query: 7 RVGKYEVGRTIGEGTFAKVKFARNT---DTGDNVAIKIMAKSTILKN-RMVDQIKREISI 62 R +E+ R +G+G + KV R +TG A+K++ K+ I++N + K E +I Sbjct: 3 RPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNI 62 Query: 63 MKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAV 122 ++ V+HP IV L + K+Y++LE+++GGELF ++ +G E + Y ++ A+ Sbjct: 63 LEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMAL 122 Query: 123 AHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLS 182 H H KG+ +RDLKPEN++L+ G++K++DFGL + T CGT Y+APE+L Sbjct: 123 GHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILM 182 Query: 183 GQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIH 242 G++ A D WS G +++ +L G PF+ + KI + + PP+ + E + L+ Sbjct: 183 RSGHN-RAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLK 241 Query: 243 RILDPNPKTRI-----QIQGIKKDPWFR-LNYVPIRAREEEEVNLD 282 ++L N +R+ ++ P+FR +N+ + AR+ E Sbjct: 242 KLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKP 287 >3D2K-A nrPDB Length = 272 Score = 299 bits (766), Expect = 2e-81, Method: Composition-based stats. Identities = 89/266 (33%), Positives = 151/266 (56%), Gaps = 3/266 (1%) Query: 2 TKKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREIS 61 +K+ + +++GR +G+G F V AR + +A+K++ K+ + K + Q++RE+ Sbjct: 5 SKRQWTLEDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVEHQLRREVE 64 Query: 62 IMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDA 121 I +RHPNI+RLY +++Y++LE+ G ++ + R +E + Y +L +A Sbjct: 65 IQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSRFDEQRTATYITELANA 124 Query: 122 VAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVL 181 +++CH K V HRD+KPENLLL +NG LK++DFG S T CGT +Y+ PE++ Sbjct: 125 LSYCHSKRVIHRDIKPENLLLGSNGELKIADFGWS--VHAPSSRRTTLCGTLDYLPPEMI 182 Query: 182 SGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLI 241 G+ +D D+WS GV+ + L G PF YR+I+ EF+ P + + + LI Sbjct: 183 EGRMHD-EKVDLWSLGVLCYEFLVGMPPFEAHTYQETYRRISRVEFTFPDFVTEGARDLI 241 Query: 242 HRILDPNPKTRIQIQGIKKDPWFRLN 267 R+L N R+ + + + PW + N Sbjct: 242 SRLLKHNASQRLTLAEVLEHPWIKAN 267 >5D9K-A nrPDB Length = 330 Score = 299 bits (765), Expect = 2e-81, Method: Composition-based stats. Identities = 93/298 (31%), Positives = 154/298 (51%), Gaps = 11/298 (3%) Query: 9 GKYEVGRTIGEGTFAKVKFARNT---DTGDNVAIKIMAKSTILKNRMVDQIKREISIMKI 65 ++E+ + +G+G+F KV + D A+K++ K+T LK R + K E I+ Sbjct: 30 SQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKAT-LKVRDRVRTKMERDILVE 88 Query: 66 VRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHC 125 V HP IV+L+ + K+Y++L+F+ GG+LF R+ + E + + Y +L A+ H Sbjct: 89 VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHL 148 Query: 126 HCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQG 185 H G+ +RDLKPEN+LLD G++K++DFGLS + + + CGT Y+APEV++ +G Sbjct: 149 HSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRG 208 Query: 186 YDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRIL 245 + +AD WS GV++F +L G LPF D I A+ P + S E + L+ + Sbjct: 209 H-TQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLF 267 Query: 246 DPNPKTRIQI-----QGIKKDPWF-RLNYVPIRAREEEEVNLDDIRAVFDGIEGSYVA 297 NP R+ + IK+ +F +++ + RE D Sbjct: 268 KRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEF 325 >4WB7-A nrPDB Length = 405 Score = 298 bits (764), Expect = 2e-81, Method: Composition-based stats. Identities = 92/307 (29%), Positives = 159/307 (51%), Gaps = 10/307 (3%) Query: 2 TKKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREIS 61 + + ++E +T+G G+F +V ++ +TG++ A+KI+ K ++K + ++ E Sbjct: 89 AQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKR 148 Query: 62 IMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDA 121 I++ V P +V+L S +Y+V+E+V GGE+F + GR E +R Y Q+V Sbjct: 149 ILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLT 208 Query: 122 VAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVL 181 + H + +RDLKPENLL+D G ++V+DFG + + T CGTP Y+APE++ Sbjct: 209 FEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG---RTWTLCGTPEYLAPEII 265 Query: 182 SGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLI 241 +GY+ A D W+ GV+++ + AGY PF +Y KI + + P FS+++K L+ Sbjct: 266 LSKGYN-KAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLL 324 Query: 242 HRILDPNPKTRI-----QIQGIKKDPWF-RLNYVPIRAREEEEVNLDDIRAVFDGIEGSY 295 +L + R + IK WF +++ I R+ E + + D Sbjct: 325 RNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDD 384 Query: 296 VAENVER 302 E R Sbjct: 385 YEEEEIR 391 >3DB8-A nrPDB Length = 317 Score = 297 bits (761), Expect = 6e-81, Method: Composition-based stats. Identities = 89/270 (32%), Positives = 140/270 (51%), Gaps = 1/270 (0%) Query: 5 MRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMK 64 R + +Y GR +G+G FAK + DT + A K++ KS +LK +++ EI+I K Sbjct: 38 PRTMKRYMRGRFLGKGGFAKCYEITDMDTKEVFAGKVVPKSMLLKPHQKEKMSTEIAIHK 97 Query: 65 IVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAH 124 + +P++V + +Y+VLE L + + + E E+R + +Q + V + Sbjct: 98 SLDNPHVVGFHGFFEDDDFVYVVLEICRRRSLLELHKRRKAVTEPEARYFMRQTIQGVQY 157 Query: 125 CHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQ 184 H V HRDLK NL L+ + ++K+ DFGL+ + E + CGTPNY+APEVL + Sbjct: 158 LHNNRVIHRDLKLGNLFLNDDMDVKIGDFGLATKIEFDGERKKDLCGTPNYIAPEVLCKK 217 Query: 185 GYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRI 244 G+ DIWS G IL+ +L G PF + L Y +I E+S P + LI R+ Sbjct: 218 GH-SFEVDIWSLGCILYTLLVGKPPFETSCLKETYIRIKKNEYSVPRHINPVASALIRRM 276 Query: 245 LDPNPKTRIQIQGIKKDPWFRLNYVPIRAR 274 L +P R + + D +F Y P+R Sbjct: 277 LHADPTLRPSVAELLTDEFFTSGYAPMRLP 306 >4I6B-A nrPDB Length = 308 Score = 297 bits (761), Expect = 6e-81, Method: Composition-based stats. Identities = 90/276 (32%), Positives = 144/276 (52%), Gaps = 1/276 (0%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 +Y G+T+G+G FAK + A KI+ S + K ++I +EI + +I+ H Sbjct: 29 RYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDKEIELHRILHHK 88 Query: 70 NIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKG 129 ++V+ Y IYI+LE+ + + + + L E E R Y +Q+V + + H + Sbjct: 89 HVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQE 148 Query: 130 VYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGS 189 + HRDLK N ++ + LKV DFGL+A + RT CGTPNY++PEVL+ QG+ G+ Sbjct: 149 ILHRDLKLGNFFINESMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGH-GA 207 Query: 190 AADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILDPNP 249 +DIW+ G +++ +L G PF T+L YR I A ++ P A K LI +L NP Sbjct: 208 ESDIWALGCVMYTMLLGRPPFETTNLKETYRSIREARYTMPSSLLAPAKHLIASMLSKNP 267 Query: 250 KTRIQIQGIKKDPWFRLNYVPIRAREEEEVNLDDIR 285 + R + I + +F + P R + D Sbjct: 268 EDRPSLDDIIRHDFFTQGFTPDRLSSSCCHTVPDFH 303 >3MV5-A nrPDB Length = 342 Score = 297 bits (761), Expect = 6e-81, Method: Composition-based stats. Identities = 87/289 (30%), Positives = 144/289 (49%), Gaps = 8/289 (2%) Query: 8 VGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR 67 + ++E + +G+GTF KV + TG A+KI+ K I+ V E +++ R Sbjct: 9 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSR 68 Query: 68 HPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHC 127 HP + L + ++ V+E+ GGELF + + E +R Y ++V A+ + H Sbjct: 69 HPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHS 128 Query: 128 -KGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGY 186 K V +RDLK ENL+LD +G++K++DFGL + ++T CGTP Y+APEVL Y Sbjct: 129 EKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDY 188 Query: 187 DGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILD 246 G A D W GV+++ ++ G LPF D L+ I E P E K L+ +L Sbjct: 189 -GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLK 247 Query: 247 PNPKTRI-----QIQGIKKDPWFR-LNYVPIRAREEEEVNLDDIRAVFD 289 +PK R+ + I + +F + + + ++ + + D Sbjct: 248 KDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETD 296 >4FG9-A nrPDB Length = 320 Score = 297 bits (761), Expect = 6e-81, Method: Composition-based stats. Identities = 99/261 (37%), Positives = 151/261 (57%), Gaps = 11/261 (4%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 Y+ +G G F++V A + T VAIK +AK + ++ EI+++ ++HPN Sbjct: 20 YDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEG--SMENEIAVLHKIKHPN 77 Query: 71 IVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGV 130 IV L ++ S +Y++++ V+GGELFDRIV KG E ++ + Q++DAV + H G+ Sbjct: 78 IVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLGI 137 Query: 131 YHRDLKPENLL---LDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYD 187 HRDLKPENLL LD + + +SDFGLS ++ +L T CGTP YVAPEVL+ + Y Sbjct: 138 VHRDLKPENLLYYSLDEDSKIMISDFGLSK-MEDPGSVLSTACGTPGYVAPEVLAQKPY- 195 Query: 188 GSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSC--PPW--FSAEVKFLIHR 243 A D WS GVI +++L GY PF + + L+ +I AE+ P W S K I Sbjct: 196 SKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIRH 255 Query: 244 ILDPNPKTRIQIQGIKKDPWF 264 +++ +P+ R + + PW Sbjct: 256 LMEKDPEKRFTCEQALQHPWI 276 >5KCV-A nrPDB Length = 460 Score = 297 bits (761), Expect = 7e-81, Method: Composition-based stats. Identities = 87/289 (30%), Positives = 144/289 (49%), Gaps = 8/289 (2%) Query: 8 VGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR 67 + ++E + +G+GTF KV + TG A+KI+ K I+ V E +++ R Sbjct: 161 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSR 220 Query: 68 HPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHC 127 HP + L + ++ V+E+ GGELF + + E +R Y ++V A+ + H Sbjct: 221 HPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHS 280 Query: 128 -KGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGY 186 K V +RDLK ENL+LD +G++K++DFGL + ++T CGTP Y+APEVL Y Sbjct: 281 EKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDY 340 Query: 187 DGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILD 246 G A D W GV+++ ++ G LPF D L+ I E P E K L+ +L Sbjct: 341 -GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLK 399 Query: 247 PNPKTRI-----QIQGIKKDPWFR-LNYVPIRAREEEEVNLDDIRAVFD 289 +PK R+ + I + +F + + + ++ + + D Sbjct: 400 KDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETD 448 >2Z7Q-A nrPDB Length = 321 Score = 297 bits (760), Expect = 8e-81, Method: Composition-based stats. Identities = 93/290 (32%), Positives = 156/290 (53%), Gaps = 11/290 (3%) Query: 11 YEVGRTIGEGTFAKVKFARNT---DTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR 67 +E+ + +G+G+F KV R D+G A+K++ K+T LK R + K E I+ V Sbjct: 30 FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKAT-LKVRDRVRTKMERDILADVN 88 Query: 68 HPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHC 127 HP +V+L+ + K+Y++L+F+ GG+LF R+ + E + + Y +L + H H Sbjct: 89 HPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHS 148 Query: 128 KGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYD 187 G+ +RDLKPEN+LLD G++K++DFGLS + + + CGT Y+APEV++ QG+ Sbjct: 149 LGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGH- 207 Query: 188 GSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILDP 247 +AD WS GV++F +L G LPF D I A+ P + S E + L+ + Sbjct: 208 SHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKR 267 Query: 248 NPKTRI-----QIQGIKKDPWF-RLNYVPIRAREEEEVNLDDIRAVFDGI 291 NP R+ + IK+ ++ +++ + RE + + D Sbjct: 268 NPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTF 317 >2JC6-A nrPDB Length = 334 Score = 296 bits (758), Expect = 1e-80, Method: Composition-based stats. Identities = 99/261 (37%), Positives = 151/261 (57%), Gaps = 11/261 (4%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 +E T+G G F++V A TG A+K + K + I+ EI++++ ++H N Sbjct: 24 FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKES--SIENEIAVLRKIKHEN 81 Query: 71 IVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGV 130 IV L ++ SP+ +Y+V++ V+GGELFDRIV KG E ++ +Q++DAV + H G+ Sbjct: 82 IVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGI 141 Query: 131 YHRDLKPENLLL---DTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYD 187 HRDLKPENLL D + +SDFGLS + +G +++ T CGTP YVAPEVL+ + Y Sbjct: 142 VHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKG-DVMSTACGTPGYVAPEVLAQKPY- 199 Query: 188 GSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSC--PPW--FSAEVKFLIHR 243 A D WS GVI +++L GY PF + + L+ +I AE+ P W S K I Sbjct: 200 SKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRN 259 Query: 244 ILDPNPKTRIQIQGIKKDPWF 264 +++ +P R + + PW Sbjct: 260 LMEKDPNKRYTCEQAARHPWI 280 >3UDB-A nrPDB Length = 317 Score = 296 bits (757), Expect = 2e-80, Method: Composition-based stats. Identities = 110/305 (36%), Positives = 160/305 (52%), Gaps = 14/305 (4%) Query: 5 MRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMK 64 M +YE+ + IG G F + R+ + VA+K + + + + +KREI + Sbjct: 15 MHDSDRYELVKDIGAGNFGVARLMRDKQANELVAVKYIERGEKID----ENVKREIINHR 70 Query: 65 IVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAH 124 +RHPNIVR EV+ +P+ + IV+E+ +GGELF+RI + GR E E+R +FQQL+ V++ Sbjct: 71 SLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSY 130 Query: 125 CHCKGVYHRDLKPENLLLDTN--GNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLS 182 H V HRDLK EN LLD + LK++DFG S + ++ GTP Y+APEVL Sbjct: 131 AHAMQVAHRDLKLENTLLDGSPAPRLKIADFGYSKASVLHSQP-KSAVGTPAYIAPEVLL 189 Query: 183 GQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRK----INAAEFSCPP--WFSAE 236 + YDG AD+WSCGV L+V+L G PF + + P +RK I +++ P S E Sbjct: 190 KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPE 249 Query: 237 VKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEE-EVNLDDIRAVFDGIEGSY 295 + LI RI +P RI I I+ WF N + D+ IE Sbjct: 250 CRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQFDESDQPGQSIEEIM 309 Query: 296 VAENV 300 Sbjct: 310 QIIAE 314 >3KK8-A nrPDB Length = 284 Score = 295 bits (756), Expect = 2e-80, Method: Composition-based stats. Identities = 100/267 (37%), Positives = 150/267 (56%), Gaps = 10/267 (3%) Query: 5 MRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMK 64 + Y+V +G+G F+ V+ + TG A KI+ L R +++RE I + Sbjct: 2 TKFSDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKK-LSARDFQKLEREARICR 60 Query: 65 IVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAH 124 ++HPNIVRL++ + S Y+V + VTGGELF+ IV + E+++ QQ+++++A+ Sbjct: 61 KLQHPNIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAY 120 Query: 125 CHCKGVYHRDLKPENLLLDTNGN---LKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVL 181 CH G+ HR+LKPENLLL + +K++DFGL+ + E GTP Y++PEVL Sbjct: 121 CHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDS-EAWHGFAGTPGYLSPEVL 179 Query: 182 SGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAA--EFSCPPW--FSAEV 237 Y DIW+CGVIL+++L GY PF + D LY +I A ++ P W + E Sbjct: 180 KKDPY-SKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYDYPSPEWDTVTPEA 238 Query: 238 KFLIHRILDPNPKTRIQIQGIKKDPWF 264 K LI +L NPK RI K PW Sbjct: 239 KSLIDSMLTVNPKKRITADQALKVPWI 265 >3SOA-A nrPDB Length = 444 Score = 295 bits (756), Expect = 2e-80, Method: Composition-based stats. Identities = 97/269 (36%), Positives = 152/269 (56%), Gaps = 9/269 (3%) Query: 3 KKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISI 62 R +Y++ +G+G F+ V+ G A ++ + L R +++RE I Sbjct: 5 TCTRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAA-MIINTKKLSARDHQKLEREARI 63 Query: 63 MKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAV 122 ++++HPNIVRL++ ++ Y++ + VTGGELF+ IV + E+++ QQ+++AV Sbjct: 64 CRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAV 123 Query: 123 AHCHCKGVYHRDLKPENLLLDTNGN---LKVSDFGLSALPQEGVELLRTTCGTPNYVAPE 179 HCH GV HR+LKPENLLL + +K++DFGL+ + + GTP Y++PE Sbjct: 124 LHCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPE 183 Query: 180 VLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAA--EFSCPPW--FSA 235 VL Y G D+W+CGVIL+++L GY PF + D LY++I A +F P W + Sbjct: 184 VLRKDPY-GKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTP 242 Query: 236 EVKFLIHRILDPNPKTRIQIQGIKKDPWF 264 E K LI+++L NP RI K PW Sbjct: 243 EAKDLINKMLTINPSKRITAAEALKHPWI 271 >4JXF-A nrPDB Length = 266 Score = 294 bits (752), Expect = 8e-80, Method: Composition-based stats. Identities = 86/263 (32%), Positives = 146/263 (55%), Gaps = 2/263 (0%) Query: 6 RRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKI 65 ++ ++VG +G+G+FA V A + TG VAIK++ K + K MV +++ E+ I Sbjct: 4 EKIEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQ 63 Query: 66 VRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHK-GRLEESESRKYFQQLVDAVAH 124 ++HP+I+ LY + +Y+VLE GE+ + ++ E+E+R + Q++ + + Sbjct: 64 LKHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLY 123 Query: 125 CHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQ 184 H G+ HRDL NLLL N N+K++DFGL+ + E T CGTPNY++PE+ + Sbjct: 124 LHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRS 183 Query: 185 GYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRI 244 + G +D+WS G + + +L G PF + K+ A++ P + S E K LIH++ Sbjct: 184 AH-GLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQL 242 Query: 245 LDPNPKTRIQIQGIKKDPWFRLN 267 L NP R+ + + P+ N Sbjct: 243 LRRNPADRLSLSSVLDHPFMSRN 265 >4RA4-A nrPDB Length = 355 Score = 293 bits (751), Expect = 8e-80, Method: Composition-based stats. Identities = 77/286 (26%), Positives = 150/286 (52%), Gaps = 8/286 (2%) Query: 7 RVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIV 66 ++ + +G+G+F KV A T + AIKI+ K ++++ V+ E ++ ++ Sbjct: 18 KLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALL 77 Query: 67 RHP-NIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHC 125 P + +L+ + ++Y V+E+V GG+L I G+ +E ++ Y ++ + Sbjct: 78 DKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFL 137 Query: 126 HCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQG 185 H +G+ +RDLK +N++LD+ G++K++DFG+ RT CGTP+Y+APE+++ Q Sbjct: 138 HKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQP 197 Query: 186 YDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRIL 245 Y G + D W+ GV+L+ +LAG PF D L++ I S P S E + ++ Sbjct: 198 Y-GKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLM 256 Query: 246 DPNPKTRIQI-----QGIKKDPWF-RLNYVPIRAREEEEVNLDDIR 285 +P R+ + +++ +F R+++ + RE + + Sbjct: 257 TKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVS 302 >3HDN-A nrPDB Length = 373 Score = 293 bits (750), Expect = 1e-79, Method: Composition-based stats. Identities = 86/301 (28%), Positives = 143/301 (47%), Gaps = 7/301 (2%) Query: 6 RRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIM-K 64 + + + IG+G+F KV AR+ A+K++ K ILK + I E +++ K Sbjct: 35 AKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLK 94 Query: 65 IVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAH 124 V+HP +V L+ + K+Y VL+++ GGELF + + E +R Y ++ A+ + Sbjct: 95 NVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGY 154 Query: 125 CHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQ 184 H + +RDLKPEN+LLD+ G++ ++DFGL E T CGTP Y+APEVL Q Sbjct: 155 LHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQ 214 Query: 185 GYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRI 244 YD + D W G +L+ +L G PF + +Y I P + + L+ + Sbjct: 215 PYDRT-VDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGL 273 Query: 245 LDPNPKTRIQIQ----GIKKDPWFRL-NYVPIRAREEEEVNLDDIRAVFDGIEGSYVAEN 299 L + R+ + IK +F L N+ + ++ ++ D Sbjct: 274 LQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTE 333 Query: 300 V 300 Sbjct: 334 E 334 >2JAM-A nrPDB Length = 304 Score = 290 bits (742), Expect = 9e-79, Method: Composition-based stats. Identities = 98/266 (36%), Positives = 146/266 (54%), Gaps = 13/266 (4%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 + +G G F++V + TG A+K + KS ++ ++ EI+++K ++H N Sbjct: 11 FIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSSLE---NEIAVLKKIKHEN 67 Query: 71 IVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGV 130 IV L ++ S + Y+V++ V+GGELFDRI+ +G E ++ QQ++ AV + H G+ Sbjct: 68 IVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHENGI 127 Query: 131 YHRDLKPENLLL---DTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYD 187 HRDLKPENLL + N + ++DFGLS + Q G ++ T CGTP YVAPEVL+ + Y Sbjct: 128 VHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNG--IMSTACGTPGYVAPEVLAQKPY- 184 Query: 188 GSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAA--EFSCPPW--FSAEVKFLIHR 243 A D WS GVI +++L GY PF E L+ KI EF P W S K I Sbjct: 185 SKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAKDFICH 244 Query: 244 ILDPNPKTRIQIQGIKKDPWFRLNYV 269 +L+ +P R + PW N Sbjct: 245 LLEKDPNERYTCEKALSHPWIDGNTA 270 >4NIF-A nrPDB Length = 333 Score = 289 bits (739), Expect = 2e-78, Method: Composition-based stats. Identities = 95/305 (31%), Positives = 156/305 (51%), Gaps = 26/305 (8%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIM-KIVRHP 69 Y V TIG G++++ K + T A+K++ KS + EI I+ + +HP Sbjct: 10 YVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSE-------EIEILLRYGQHP 62 Query: 70 NIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKG 129 NI+ L +V +Y+V E + GGEL D+I+ + E E+ + V + H +G Sbjct: 63 NIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQG 122 Query: 130 VYHRDLKPENLL-LDTNGN---LKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQG 185 V HRDLKP N+L +D +GN L++ DFG + + LL T C T N+VAPEVL QG Sbjct: 123 VVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQG 182 Query: 186 YDGSAADIWSCGVILFVILAGYLPF---SETDLPGLYRKINAAEFSCPPW----FSAEVK 238 YD DIWS G++L+ +LAGY PF + +I + +F+ S K Sbjct: 183 YD-EGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAK 241 Query: 239 FLIHRILDPNPKTRIQIQGIKKDPWF-RLNYVPIRAREEEEVNLDDIRAVFDGIEGSYVA 297 L+ ++L +P R+ + + + PW + + +P + +++ D++ V + +Y A Sbjct: 242 DLVSKMLHVDPHQRLTAKQVLQHPWVTQKDKLP-----QSQLSHQDLQLVKGAMAATYSA 296 Query: 298 ENVER 302 N + Sbjct: 297 LNSSK 301 >4B8L-A nrPDB Length = 286 Score = 287 bits (736), Expect = 5e-78, Method: Composition-based stats. Identities = 95/283 (33%), Positives = 153/283 (54%), Gaps = 3/283 (1%) Query: 1 MTKKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREI 60 M K+ + +++GR +G+G F V AR +A+K++ KS + K + Q++REI Sbjct: 7 MPKRKFTIDDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRREI 66 Query: 61 SIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVD 120 I +RHPNI+R+Y +IY++LEF GEL+ + GR +E S + ++L D Sbjct: 67 EIQSHLRHPNILRMYNYFHDRKRIYLMLEFAPRGELYKELQKHGRFDEQRSATFMEELAD 126 Query: 121 AVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEV 180 A+ +CH + V HRD+KPENLL+ G LK++DFG S RT CGT +Y+ PE+ Sbjct: 127 ALHYCHERKVIHRDIKPENLLMGYKGELKIADFGWS--VHAPSLRRRTMCGTLDYLPPEM 184 Query: 181 LSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFL 240 + G+ +D D+W GV+ + L G PF +R+I + PP+ S K L Sbjct: 185 IEGKTHD-EKVDLWCAGVLCYEFLVGMPPFDSPSHTETHRRIVNVDLKFPPFLSDGSKDL 243 Query: 241 IHRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEVNLDD 283 I ++L +P R+ ++G+ + PW + N + + D Sbjct: 244 ISKLLRYHPPQRLPLKGVMEHPWVKANSRRVLPGVYQSTQSKD 286 >2OU7-A nrPDB Length = 335 Score = 287 bits (736), Expect = 5e-78, Method: Composition-based stats. Identities = 86/258 (33%), Positives = 133/258 (51%), Gaps = 1/258 (0%) Query: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYE 76 +G+G FAK + DT + A KI+ KS +LK +++ EISI + + H ++V + Sbjct: 49 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 108 Query: 77 VLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDLK 136 +++VLE L + + L E E+R Y +Q+V + H V HRDLK Sbjct: 109 FFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLK 168 Query: 137 PENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSAADIWSC 196 NL L+ + +K+ DFGL+ + E + CGTPNY+APEVLS +G+ D+WS Sbjct: 169 LGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGH-SFEVDVWSI 227 Query: 197 GVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILDPNPKTRIQIQ 256 G I++ +L G PF + L Y +I E+S P + LI ++L +P R I Sbjct: 228 GCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTIN 287 Query: 257 GIKKDPWFRLNYVPIRAR 274 + D +F Y+P R Sbjct: 288 ELLNDEFFTSGYIPARLP 305 >6E9W-A nrPDB Length = 443 Score = 285 bits (731), Expect = 2e-77, Method: Composition-based stats. Identities = 96/310 (30%), Positives = 156/310 (50%), Gaps = 19/310 (6%) Query: 7 RVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIV 66 + YEV + IG G F +V+ R+ T A+K+++K ++K E IM Sbjct: 100 KAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFA 159 Query: 67 RHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCH 126 P +V+L+ +Y+V+E++ GG+L + ++ + E +R Y ++V A+ H Sbjct: 160 NSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVN-LMSNYDVPEKWARFYTAEVVLALDAIH 218 Query: 127 CKGVYHRDLKPENLLLDTNGNLKVSDFGLS-ALPQEGVELLRTTCGTPNYVAPEVLS--- 182 G HRD+KP+N+LLD +G+LK++DFG + +EG+ T GTP+Y++PEVL Sbjct: 219 SMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQG 278 Query: 183 GQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAE----FSCPPWFSAEVK 238 G GY G D WS GV L+ +L G PF L G Y KI + F S E K Sbjct: 279 GDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAK 338 Query: 239 FLIHRILDPNPKTRI---QIQGIKKDPWFRLN---YVPIR---AREEEEVNLDDIRAVFD 289 LI L + + R+ ++ IK+ +F+ + + +R A +++ D + FD Sbjct: 339 NLICAFLT-DREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNFD 397 Query: 290 GIEGSYVAEN 299 +E E Sbjct: 398 DLEEDKGEEE 407 >4J52-A nrPDB Length = 293 Score = 285 bits (731), Expect = 2e-77, Method: Composition-based stats. Identities = 86/258 (33%), Positives = 133/258 (51%), Gaps = 1/258 (0%) Query: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYE 76 +G+G FAK + DT + A KI+ KS +LK +++ EISI + + H ++V + Sbjct: 22 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 81 Query: 77 VLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDLK 136 +++VLE L + + L E E+R Y +Q+V + H V HRDLK Sbjct: 82 FFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLK 141 Query: 137 PENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSAADIWSC 196 NL L+ + +K+ DFGL+ + E + CGTPNY+APEVLS +G+ D+WS Sbjct: 142 LGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGH-SFEVDVWSI 200 Query: 197 GVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILDPNPKTRIQIQ 256 G I++ +L G PF + L Y +I E+S P + LI ++L +P R I Sbjct: 201 GCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTIN 260 Query: 257 GIKKDPWFRLNYVPIRAR 274 + D +F Y+P R Sbjct: 261 ELLNDEFFTSGYIPARLP 278 >6CMJ-A nrPDB Length = 321 Score = 285 bits (730), Expect = 2e-77, Method: Composition-based stats. Identities = 95/288 (32%), Positives = 162/288 (56%), Gaps = 16/288 (5%) Query: 7 RVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNR--------MVDQIKR 58 ++ +Y + IG+G++ VK A N + A+K+++K +++ ++Q+ + Sbjct: 32 QLDQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGGCIQPRGPIEQVYQ 91 Query: 59 EISIMKIVRHPNIVRLYEVLASPS--KIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQ 116 EI+I+K + HPN+V+L EVL P+ +Y+V E V G + + + L E ++R YFQ Sbjct: 92 EIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTLKPLSEDQARFYFQ 150 Query: 117 QLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYV 176 L+ + + H + + HRD+KP NLL+ +G++K++DFG+S + LL T GTP ++ Sbjct: 151 DLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFM 210 Query: 177 APEVLSGQG--YDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCP--PW 232 APE LS + G A D+W+ GV L+ + G PF + + L+ KI + P P Sbjct: 211 APESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPD 270 Query: 233 FSAEVKFLIHRILDPNPKTRIQIQGIKKDPWF-RLNYVPIRAREEEEV 279 + ++K LI R+LD NP++RI + IK PW R P+ + +E Sbjct: 271 IAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCT 318 >3PFQ-A nrPDB Length = 674 Score = 285 bits (730), Expect = 3e-77, Method: Composition-based stats. Identities = 79/303 (26%), Positives = 153/303 (50%), Gaps = 16/303 (5%) Query: 7 RVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKI- 65 ++ + +G+G+F KV + T + A+KI+ K ++++ V+ E ++ + Sbjct: 339 KLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALP 398 Query: 66 VRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHC 125 + P + +L+ + ++Y V+E+V GG+L I GR +E + Y ++ + Sbjct: 399 GKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFL 458 Query: 126 HCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQG 185 KG+ +RDLK +N++LD+ G++K++DFG+ +T CGTP+Y+APE+++ Q Sbjct: 459 QSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQP 518 Query: 186 YDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRIL 245 Y G + D W+ GV+L+ +LAG PF D L++ I + P S E + ++ Sbjct: 519 Y-GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLM 577 Query: 246 DPNPKTRIQI-----QGIKKDPWFR-LNYVPIRAREEEEVNLDDIRAVFDGIEGSYVAEN 299 +P R+ + IK+ +FR +++ + +E + + AEN Sbjct: 578 TKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPP--------YKPKASGRNAEN 629 Query: 300 VER 302 +R Sbjct: 630 FDR 632 >3F3Z-A nrPDB Length = 277 Score = 285 bits (730), Expect = 3e-77, Method: Composition-based stats. Identities = 106/264 (40%), Positives = 149/264 (56%), Gaps = 13/264 (4%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 Y + TIG G++ +VK A T A K + K + VD+ K+EI IMK + HPN Sbjct: 11 YTLENTIGRGSWGEVKIAVQKGTRIRRAAKKIPKYFV---EDVDRFKQEIEIMKSLDHPN 67 Query: 71 IVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGV 130 I+RLYE + IY+V+E TGGELF+R+VHK ES++ + + ++ AVA+CH V Sbjct: 68 IIRLYETFEDNTDIYLVMELCTGGELFERVVHKRVFRESDAARIMKDVLSAVAYCHKLNV 127 Query: 131 YHRDLKPENLLL---DTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYD 187 HRDLKPEN L + LK+ DFGL+A + G +++RT GTP YV+P+VL +G Sbjct: 128 AHRDLKPENFLFLTDSPDSPLKLIDFGLAARFKPG-KMMRTKVGTPYYVSPQVL--EGLY 184 Query: 188 GSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPW----FSAEVKFLIHR 243 G D WS GV+++V+L GY PFS + KI F+ P S + + LI R Sbjct: 185 GPECDEWSAGVMMYVLLCGYPPFSAPTDSEVMLKIREGTFTFPEKDWLNVSPQAESLIRR 244 Query: 244 ILDPNPKTRIQIQGIKKDPWFRLN 267 +L +PK RI + WF Sbjct: 245 LLTKSPKQRITSLQALEHEWFEKQ 268 >2BPM-A nrPDB Length = 309 Score = 285 bits (729), Expect = 3e-77, Method: Composition-based stats. Identities = 88/306 (28%), Positives = 137/306 (44%), Gaps = 33/306 (10%) Query: 8 VGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR 67 + ++ IGEGT+ V ARN TG+ VA+K + T + I REIS++K + Sbjct: 6 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAI-REISLLKELN 64 Query: 68 HPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKG--RLEESESRKYFQQLVDAVAHC 125 HPNIV+L +V+ + +K+Y+V EF+ +L + + + Y QL+ +A C Sbjct: 65 HPNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 123 Query: 126 HCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQG 185 H V HRDLKP+NLL++T G +K++DFGL+ V T Y APE+L G Sbjct: 124 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 183 Query: 186 YDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAA------------------EF 227 Y +A DIWS G I ++ F +I + Sbjct: 184 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 243 Query: 228 SCPPW-----------FSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREE 276 S P W + + L+ ++L +P RI + P+F+ P+ Sbjct: 244 SFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 303 Query: 277 EEVNLD 282 E + D Sbjct: 304 ERPHRD 309 >3COM-A nrPDB Length = 314 Score = 284 bits (728), Expect = 5e-77, Method: Composition-based stats. Identities = 75/269 (27%), Positives = 129/269 (47%), Gaps = 12/269 (4%) Query: 1 MTKKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREI 60 +TK+ V ++V +GEG++ V A + +TG VAIK + + + +I +EI Sbjct: 23 LTKQPEEV--FDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVES-----DLQEIIKEI 75 Query: 61 SIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIV-HKGRLEESESRKYFQQLV 119 SIM+ P++V+ Y + ++IV+E+ G + D I L E E Q + Sbjct: 76 SIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTL 135 Query: 120 DAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPE 179 + + H HRD+K N+LL+T G+ K++DFG++ + + T GTP ++APE Sbjct: 136 KGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPE 195 Query: 180 VLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAE---FSCPPWFSAE 236 V+ GY+ ADIWS G+ + G P+++ I F P +S Sbjct: 196 VIQEIGYNCV-ADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDN 254 Query: 237 VKFLIHRILDPNPKTRIQIQGIKKDPWFR 265 + + L +P+ R + + P+ R Sbjct: 255 FTDFVKQCLVKSPEQRATATQLLQHPFVR 283 >6ED6-A nrPDB Length = 415 Score = 283 bits (725), Expect = 9e-77, Method: Composition-based stats. Identities = 93/305 (30%), Positives = 154/305 (50%), Gaps = 19/305 (6%) Query: 7 RVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIV 66 + Y+V + IG G F +V+ R+ + A+K+++K ++K E IM Sbjct: 86 KAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFA 145 Query: 67 RHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCH 126 P +V+L+ +Y+V+E++ GG+L + ++ + E ++ Y ++V A+ H Sbjct: 146 NSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVN-LMSNYDVPEKWAKFYTAEVVLALDAIH 204 Query: 127 CKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQE-GVELLRTTCGTPNYVAPEVLS--- 182 G+ HRD+KP+N+LLD +G+LK++DFG E G+ T GTP+Y++PEVL Sbjct: 205 SMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQG 264 Query: 183 GQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAE----FSCPPWFSAEVK 238 G G+ G D WS GV L+ +L G PF L G Y KI + F S K Sbjct: 265 GDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAK 324 Query: 239 FLIHRILDPNPKTRI---QIQGIKKDPWFRLN---YVPIR---AREEEEVNLDDIRAVFD 289 LI L + + R+ ++ I++ P+F+ + + IR A E++ D + FD Sbjct: 325 NLICAFLT-DREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDIDSSNFD 383 Query: 290 GIEGS 294 IE Sbjct: 384 DIEDD 388 >5XZW-A nrPDB Length = 471 Score = 282 bits (723), Expect = 1e-76, Method: Composition-based stats. Identities = 89/270 (32%), Positives = 142/270 (52%), Gaps = 21/270 (7%) Query: 13 VGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIV 72 + +G+G FA VK A TG A+KI++K ++ N +D + RE+ +++ + HP IV Sbjct: 200 IDEVVGQGAFATVKKAIERTTGKTFAVKIISKRKVIGN--MDGVTRELEVLQKLNHPRIV 257 Query: 73 RLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYH 132 RL Y+V+EFV+GG+L D + G + E R+ +Q++ A+ + H G+ H Sbjct: 258 RLKGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSMGISH 317 Query: 133 RDLKPENLLLDTNGN--LKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQG----- 185 RDLKP+N+L++ + +K++DFGL+ Q ++T CGT YVAPEV+ G+ Sbjct: 318 RDLKPDNILIEQDDPVLVKITDFGLAK-VQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSP 376 Query: 186 -------YDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPP----WFS 234 S D+WS G +++VIL G+LPFS + LY++I + P S Sbjct: 377 DEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRGSYHEGPLKDFRIS 436 Query: 235 AEVKFLIHRILDPNPKTRIQIQGIKKDPWF 264 E + I +L +P R PW Sbjct: 437 EEARDFIDSLLQVDPNNRSTAAKALNHPWI 466 >2I0E-A nrPDB Length = 353 Score = 282 bits (722), Expect = 2e-76, Method: Composition-based stats. Identities = 75/284 (26%), Positives = 147/284 (51%), Gaps = 8/284 (2%) Query: 7 RVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKI- 65 ++ + +G+G+F KV + T + A+KI+ K ++++ V+ E ++ + Sbjct: 18 KLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALP 77 Query: 66 VRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHC 125 + P + +L+ + ++Y V+E+V GG+L I GR +E + Y ++ + Sbjct: 78 GKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFL 137 Query: 126 HCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQG 185 KG+ +RDLK +N++LD+ G++K++DFG+ +T CGTP+Y+APE+++ Q Sbjct: 138 QSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQP 197 Query: 186 YDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRIL 245 Y G + D W+ GV+L+ +LAG PF D L++ I + P S E + ++ Sbjct: 198 Y-GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLM 256 Query: 246 DPNPKTRIQI-----QGIKKDPWFR-LNYVPIRAREEEEVNLDD 283 +P R+ + IK+ +FR +++ + +E + Sbjct: 257 TKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPK 300 >2W4O-A nrPDB Length = 349 Score = 281 bits (720), Expect = 3e-76, Method: Composition-based stats. Identities = 99/284 (34%), Positives = 157/284 (55%), Gaps = 15/284 (5%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 +EV +G G + V + T A+K++ K+ K ++ EI ++ + HPN Sbjct: 55 FEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKK-----IVRTEIGVLLRLSHPN 109 Query: 71 IVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGV 130 I++L E+ +P++I +VLE VTGGELFDRIV KG E ++ +Q+++AVA+ H G+ Sbjct: 110 IIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGI 169 Query: 131 YHRDLKPENLLLDT---NGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYD 187 HRDLKPENLL T + LK++DFGLS + + V L++T CGTP Y APE+L G Y Sbjct: 170 VHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQV-LMKTVCGTPGYCAPEILRGCAY- 227 Query: 188 GSAADIWSCGVILFVILAGYLPFSETDLPG-LYRKINAAEFSC-PPWFSA---EVKFLIH 242 G D+WS G+I +++L G+ PF + ++R+I E+ PW+ K L+ Sbjct: 228 GPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVR 287 Query: 243 RILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEVNLDDIRA 286 +++ +PK R+ + PW + + L + A Sbjct: 288 KLIVLDPKKRLTTFQALQHPWVTGKAANFVHMDTAQKKLQEFNA 331 >2YAB-A nrPDB Length = 361 Score = 281 bits (719), Expect = 5e-76, Method: Composition-based stats. Identities = 101/298 (33%), Positives = 160/298 (53%), Gaps = 14/298 (4%) Query: 3 KKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRM---VDQIKRE 59 K+ + Y++G +G G FA VK R TG A K + K +R ++I+RE Sbjct: 6 KQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIERE 65 Query: 60 ISIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLV 119 +SI++ V HPNI+ L++V + + + ++LE V+GGELFD + K L E E+ + +Q++ Sbjct: 66 VSILRQVLHPNIITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQIL 125 Query: 120 DAVAHCHCKGVYHRDLKPENL-LLDTN---GNLKVSDFGLSALPQEGVELLRTTCGTPNY 175 D V + H K + H DLKPEN+ LLD N ++K+ DFGL+ ++GVE + GTP + Sbjct: 126 DGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVE-FKNIFGTPEF 184 Query: 176 VAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWF-- 233 VAPE+++ + G AD+WS GVI +++L+G PF I A + F Sbjct: 185 VAPEIVNYEP-LGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFS 243 Query: 234 --SAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRL-NYVPIRAREEEEVNLDDIRAVF 288 S K I ++L + R+ IQ + PW + R E VNL++ + + Sbjct: 244 QTSELAKDFIRKLLVKETRKRLTIQEALRHPWITPVDTQQAMVRRESVVNLENFKKQY 301 >4JG6-A nrPDB Length = 355 Score = 280 bits (717), Expect = 9e-76, Method: Composition-based stats. Identities = 96/305 (31%), Positives = 150/305 (49%), Gaps = 23/305 (7%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIM-KIVRHP 69 YEV IG G+++ K + T A+KI+ KS EI I+ + +HP Sbjct: 37 YEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTE-------EIEILLRYGQHP 89 Query: 70 NIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKG 129 NI+ L +V +Y+V E + GGEL D+I+ + E E+ + V + H +G Sbjct: 90 NIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQG 149 Query: 130 VYHRDLKPENLL-LDTNGN---LKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQG 185 V HRDLKP N+L +D +GN +++ DFG + + LL T C T N+VAPEVL QG Sbjct: 150 VVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLERQG 209 Query: 186 YDGSAADIWSCGVILFVILAGYLPF---SETDLPGLYRKINAAEFSCP----PWFSAEVK 238 YD A DIWS GV+L+ +L GY PF + + +I + +FS S K Sbjct: 210 YDA-ACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAK 268 Query: 239 FLIHRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEVNLDDIRAVFDGIEGSYVAE 298 L+ ++L +P R+ + + PW +++ + + D V + +Y A Sbjct: 269 DLVSKMLHVDPHQRLTAALVLRHPWI-VHWDQLPQYQLNR--QDAPHLVKGAMAATYSAL 325 Query: 299 NVERN 303 N ++ Sbjct: 326 NRNQS 330 >3TAC-A nrPDB Length = 361 Score = 279 bits (714), Expect = 2e-75, Method: Composition-based stats. Identities = 95/336 (28%), Positives = 157/336 (46%), Gaps = 29/336 (8%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMA--KSTILKNRMVDQIKREISIMKIVRH 68 YE+ IG+G F+ V+ N +TG A+KI+ K T + +KRE SI +++H Sbjct: 28 YELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKH 87 Query: 69 PNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGR----LEESESRKYFQQLVDAVAH 124 P+IV L E +S +Y+V EF+ G +L IV + E+ + Y +Q+++A+ + Sbjct: 88 PHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRY 147 Query: 125 CHCKGVYHRDLKPENLLLDTNGN---LKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVL 181 CH + HRD+KP +LL + N +K+ FG++ E + GTP+++APEV+ Sbjct: 148 CHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFMAPEVV 207 Query: 182 SGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPP----WFSAEV 237 + Y G D+W CGVILF++L+G LPF T L+ I ++ P S Sbjct: 208 KREPY-GKPVDVWGCGVILFILLSGCLPFYGTK-ERLFEGIIKGKYKMNPRQWSHISESA 265 Query: 238 KFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEVNLDDIRAVFDGIEGSYVA 297 K L+ R+L +P RI + PW + R R +++L + +E Sbjct: 266 KDLVRRMLMLDPAERITVYEALNHPWLKE-----RDRYAYKIHLPE------TVEQLRKF 314 Query: 298 ENVERNDE---GPLMMNAFEMITLSQGLNLSALFDR 330 + + + F L + Sbjct: 315 NARRKLKGAVLAAVSSHKFNSFYGDPPEELPDFSED 350 >2J90-A nrPDB Length = 304 Score = 278 bits (711), Expect = 4e-75, Method: Composition-based stats. Identities = 89/268 (33%), Positives = 148/268 (55%), Gaps = 13/268 (4%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRM---VDQIKREISIMKI 65 YE+G +G G FA V+ R TG A K + K + +R ++I+RE++I++ Sbjct: 26 DHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILRE 85 Query: 66 VRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHC 125 +RHPNI+ L+++ + + + ++LE V+GGELFD + K L E E+ ++ +Q++D V + Sbjct: 86 IRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDGVHYL 145 Query: 126 HCKGVYHRDLKPENLLLDT----NGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVL 181 H K + H DLKPEN++L N +K+ DFG++ + G E + GTP +VAPE++ Sbjct: 146 HSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNE-FKNIFGTPEFVAPEIV 204 Query: 182 SGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWF----SAEV 237 + + G AD+WS GVI +++L+G PF I+A + + S Sbjct: 205 NYEP-LGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFSNTSELA 263 Query: 238 KFLIHRILDPNPKTRIQIQGIKKDPWFR 265 K I R+L +PK R+ I + W + Sbjct: 264 KDFIRRLLVKDPKRRMTIAQSLEHSWIK 291 >6FDY-U nrPDB Length = 276 Score = 277 bits (708), Expect = 9e-75, Method: Composition-based stats. Identities = 93/272 (34%), Positives = 142/272 (52%), Gaps = 9/272 (3%) Query: 5 MRRVGKYEVGRTIGEGTFAKVKFAR-NTDTGDNVAIKIMAKSTILKNRMVDQIKREISIM 63 R+ + + +G GT+A V A DT + VAIK +AK ++ K V+ + EI I+ Sbjct: 7 PPRLDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKAS-VENLLTEIEIL 65 Query: 64 KIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVA 123 K +RHP+IV+L + IY+++EF GG+L I + L E +R + QQL A+ Sbjct: 66 KGIRHPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQ 125 Query: 124 HCHCKGVYHRDLKPENLLLD--TNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVL 181 H + + H DLKP+N+LL +LK++DFG + E G+P Y+APE++ Sbjct: 126 FLHERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKH-VLRGSPLYMAPEMV 184 Query: 182 SGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAA---EFSCPPWFSAEVK 238 + YD D+WS GVIL+ L G PF+ L KI + E P S + + Sbjct: 185 CQRQYDA-RVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPLLSRDCR 243 Query: 239 FLIHRILDPNPKTRIQIQGIKKDPWFRLNYVP 270 L+ R+L+ +P RI Q PW L ++P Sbjct: 244 DLLQRLLERDPSRRISFQDFFAHPWVDLEHMP 275 >3ORZ-A nrPDB Length = 316 Score = 276 bits (707), Expect = 1e-74, Method: Composition-based stats. Identities = 81/278 (29%), Positives = 144/278 (51%), Gaps = 9/278 (3%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 ++ G+ +GEG+F+ V AR T AIKI+ K I+K V + RE +M + H Sbjct: 37 EDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDH 96 Query: 69 PNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCK 128 P V+LY K+Y L + GEL I G +E+ +R Y ++V A+ + H K Sbjct: 97 PFFVKLYFCFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGK 156 Query: 129 GVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLR--TTCGTPNYVAPEVLSGQGY 186 G+ HRDLKPEN+LL+ + +++++DFG + + + R + GT YV+PE+L+ + Sbjct: 157 GIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKS- 215 Query: 187 DGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILD 246 ++D+W+ G I++ ++AG PF + +++KI E+ P F + + L+ ++L Sbjct: 216 ACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLV 275 Query: 247 PNPKTRIQIQG------IKKDPWFRLNYVPIRAREEEE 278 + R+ + +K P+F ++ Sbjct: 276 LDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPP 313 >4LG4-A nrPDB Length = 299 Score = 276 bits (707), Expect = 1e-74, Method: Composition-based stats. Identities = 74/275 (26%), Positives = 132/275 (48%), Gaps = 13/275 (4%) Query: 1 MTKKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREI 60 +TK+ V ++V +GEG++ V A + ++G VAIK + + + +I +EI Sbjct: 5 LTKQPEEV--FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVES-----DLQEIIKEI 57 Query: 61 SIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIV-HKGRLEESESRKYFQQLV 119 SIM+ P +V+ Y + ++IV+E+ G + D I L E E + + Sbjct: 58 SIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTL 117 Query: 120 DAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPE 179 + + H HR++K N+LL+T G+ K++DFG++ + + T GTP ++APE Sbjct: 118 KGLEYLHFMRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPE 177 Query: 180 VLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAE---FSCPPWFSAE 236 V+ GY+ ADIWS G+ + G P+++ I F P +S + Sbjct: 178 VIQEIGYNCV-ADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDD 236 Query: 237 VKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVPI 271 + + L NP+ R + + P+ + N P+ Sbjct: 237 FTDFVKKCLVKNPEQRATATQLLQHPFIK-NAKPV 270 >2A27-A nrPDB Length = 321 Score = 276 bits (707), Expect = 1e-74, Method: Composition-based stats. Identities = 100/298 (33%), Positives = 159/298 (53%), Gaps = 14/298 (4%) Query: 3 KKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRM---VDQIKRE 59 K+ + Y++G +G G FA VK R TG A K + K +R ++I+RE Sbjct: 6 KQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIERE 65 Query: 60 ISIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLV 119 +SI++ V H N++ L++V + + + ++LE V+GGELFD + K L E E+ + +Q++ Sbjct: 66 VSILRQVLHHNVITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQIL 125 Query: 120 DAVAHCHCKGVYHRDLKPENL-LLDTN---GNLKVSDFGLSALPQEGVELLRTTCGTPNY 175 D V + H K + H DLKPEN+ LLD N ++K+ DFGL+ ++GVE + GTP + Sbjct: 126 DGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVE-FKNIFGTPEF 184 Query: 176 VAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWF-- 233 VAPE+++ + G AD+WS GVI +++L+G PF I A + F Sbjct: 185 VAPEIVNYEP-LGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFS 243 Query: 234 --SAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRL-NYVPIRAREEEEVNLDDIRAVF 288 S K I ++L + R+ IQ + PW + R E VNL++ R + Sbjct: 244 QTSELAKDFIRKLLVKETRKRLTIQEALRHPWITPVDNQQAMVRRESVVNLENFRKQY 301 >5FET-A nrPDB Length = 847 Score = 276 bits (706), Expect = 2e-74, Method: Composition-based stats. Identities = 100/317 (31%), Positives = 155/317 (48%), Gaps = 13/317 (4%) Query: 1 MTKKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREI 60 M + + E R IG GTF VK + T A+K ++K +I+ + IK E Sbjct: 525 MQDTKVEMHELETERIIGRGTFGTVKLVHHKPTQIRYALKCVSKRSIISLNQQNNIKLER 584 Query: 61 SIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVD 120 I HP I+RL + Y + E VTGGEL+D I G L + +++ Y ++ Sbjct: 585 EITAENDHPFIIRLVRTFKDSNCFYFLTELVTGGELYDAIRKLGLLSKPQAQFYLGSIIL 644 Query: 121 AVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEV 180 A+ + H + + +RDLKPEN+LLD G +K+ DFG + Q T GTP+Y+APEV Sbjct: 645 AIEYLHERNIVYRDLKPENILLDKQGYVKLIDFGCAKKIQG---RAYTLVGTPHYMAPEV 701 Query: 181 LSGQGYDGSAADIWSCGVILFVILAGYLPF--SETDLPGLYRKINAAEFSCPPWFS-AEV 237 + G+GY G DIW+ GV L+ + G LPF + D ++R I + + P + S + Sbjct: 702 ILGKGY-GCTVDIWALGVCLYEFICGPLPFGNDQEDQLEIFRDILTGQLTFPDYVSDQDS 760 Query: 238 KFLIHRILDPNPKTRI-----QIQGIKKDPWF-RLNYVPIRAREEEEVNLDDIRAVFDGI 291 L+ R+L P+ RI + IK+ +F N+ + R E + + I Sbjct: 761 INLMKRLLCRLPQGRIGCSINGFKDIKEHAFFGNFNWDKLAGRLLEPPLVSKGETYAEDI 820 Query: 292 EGSYVAENVERNDEGPL 308 + + E N+ PL Sbjct: 821 DIKQIEEEDALNEGEPL 837 >5YV8-A nrPDB Length = 298 Score = 276 bits (706), Expect = 2e-74, Method: Composition-based stats. Identities = 92/288 (31%), Positives = 156/288 (54%), Gaps = 30/288 (10%) Query: 7 RVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNR--------------- 51 ++ +Y + IG+G++ VK A N + A+K+++K +++ Sbjct: 11 QLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAP 70 Query: 52 --------MVDQIKREISIMKIVRHPNIVRLYEVLASPS--KIYIVLEFVTGGELFDRIV 101 ++Q+ +EI+I+K + HPN+V+L EVL P+ +Y+V E V G + + + Sbjct: 71 GGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VP 129 Query: 102 HKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQE 161 L E ++R YFQ L+ + + H + + HRD+KP NLL+ +G++K++DFG+S + Sbjct: 130 TLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKG 189 Query: 162 GVELLRTTCGTPNYVAPEVLSGQG--YDGSAADIWSCGVILFVILAGYLPFSETDLPGLY 219 LL T GTP ++APE LS + G A D+W+ GV L+ + G PF + + L+ Sbjct: 190 SDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLH 249 Query: 220 RKINAAEFSCP--PWFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFR 265 KI + P P + ++K LI R+LD NP++RI + IK PW Sbjct: 250 SKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVT 297 >5JZN-A nrPDB Length = 280 Score = 275 bits (705), Expect = 2e-74, Method: Composition-based stats. Identities = 98/267 (36%), Positives = 144/267 (53%), Gaps = 16/267 (5%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 +Y+VGRTIG+G FA VK T A+KI+ KS + I+ E+SI++ V+H Sbjct: 19 ERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHM--IQNEVSILRRVKH 76 Query: 69 PNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCK 128 PNIV L E + P+++Y+V+E V GG+LFD I + E ++ L A+ + H Sbjct: 77 PNIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNLASAIKYLHSL 136 Query: 129 GVYHRDLKPENLLL----DTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQ 184 + HRD+KPENLL+ D + +LK+ DFGL+ + L T CGTP YVAPE+++ Sbjct: 137 NIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGP---LYTVCGTPTYVAPEIIAET 193 Query: 185 GYDGSAADIWSCGVILFVILAGYLPF--SETDLPGLYRKINAAEFSCP----PWFSAEVK 238 GY G DIW+ GVI +++L G+ PF S D L+ +I + P S K Sbjct: 194 GY-GLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAK 252 Query: 239 FLIHRILDPNPKTRIQIQGIKKDPWFR 265 LI +L + R + + PW Sbjct: 253 ELITMMLLVDVDQRFSAVQVLEHPWVN 279 >1VZO-A nrPDB Length = 355 Score = 275 bits (703), Expect = 3e-74, Method: Composition-based stats. Identities = 93/300 (31%), Positives = 161/300 (53%), Gaps = 19/300 (6%) Query: 8 VGKYEVGRTIGEGTFAKVKFARNT---DTGDNVAIKIMAKSTI-LKNRMVDQIKREISIM 63 + +E+ + +G G + KV R DTG A+K++ K+TI K + + + E ++ Sbjct: 53 IENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVL 112 Query: 64 KIVR-HPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAV 122 + +R P +V L+ + +K++++L+++ GGELF + + R E E + Y ++V A+ Sbjct: 113 EHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLAL 172 Query: 123 AHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSA-LPQEGVELLRTTCGTPNYVAPEVL 181 H H G+ +RD+K EN+LLD+NG++ ++DFGLS + E CGT Y+AP+++ Sbjct: 173 EHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYDFCGTIEYMAPDIV 232 Query: 182 SG--QGYDGSAADIWSCGVILFVILAGYLPF----SETDLPGLYRKINAAEFSCPPWFSA 235 G G+D A D WS GV+++ +L G PF + + R+I +E P SA Sbjct: 233 RGGDSGHD-KAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSA 291 Query: 236 EVKFLIHRILDPNPKTRI-----QIQGIKKDPWF-RLNYVPIRAREEEEVNLDDIRAVFD 289 K LI R+L +PK R+ IK+ +F ++N+ + A++ IR D Sbjct: 292 LAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDELD 351 >4CSV-A nrPDB Length = 275 Score = 275 bits (703), Expect = 3e-74, Method: Composition-based stats. Identities = 63/257 (24%), Positives = 114/257 (44%), Gaps = 10/257 (3%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 + + R +G G F +V + + VA+K + + T+ V++ +E IMK ++H Sbjct: 11 SEITLERKLGSGQFGEVYEGKWRNYNIEVAVKTLKEGTMS----VEEFLQEAQIMKKLKH 66 Query: 69 PNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHK--GRLEESESRKYFQQLVDAVAHCH 126 PN+V+LY V IYI+ E+++ G L D + + Q+ +A+ Sbjct: 67 PNLVQLYGVCTKEPPIYIITEYMSHGSLLDYLRDCEGHTVNAQALLDMAAQVASGMAYLE 126 Query: 127 CKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTP-NYVAPEVLSGQG 185 + HRDL N L+ N +KV+DFGL+ L E R P + APE +S Sbjct: 127 SQNFIHRDLAARNCLVGENNVVKVADFGLARLINEDEYTARAGAKFPIKWTAPEAISYNR 186 Query: 186 YDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAA-EFSCPPWFSAEVKFLIHR 243 + +D+W+ G++L+ I G +P+ + ++ P E+ L+ + Sbjct: 187 F-SIKSDVWAFGILLWEIFTYGQVPYPGMSGSEVIEQVERGYRMPRPQGCPEEIYELMLQ 245 Query: 244 ILDPNPKTRIQIQGIKK 260 + +P+ R Sbjct: 246 CWNKSPEERPTFAETLH 262 >2YCR-A nrPDB Length = 323 Score = 275 bits (703), Expect = 3e-74, Method: Composition-based stats. Identities = 103/298 (34%), Positives = 156/298 (52%), Gaps = 22/298 (7%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQ-----IKREISIM 63 +Y + +T+G G +VK A T VAIKI++K + ++ EI I+ Sbjct: 10 DEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEIL 69 Query: 64 KIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVA 123 K + HP I+++ + YIVLE + GGELFD++V RL+E+ + YF Q++ AV Sbjct: 70 KKLNHPCIIKIKNFFDAEDY-YIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQ 128 Query: 124 HCHCKGVYHRDLKPENLLLD---TNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEV 180 + H G+ HRDLKPEN+LL + +K++DFG S + E L+RT CGTP Y+APEV Sbjct: 129 YLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGET-SLMRTLCGTPTYLAPEV 187 Query: 181 L--SGQGYDGSAADIWSCGVILFVILAGYLPFSET-DLPGLYRKINAAEFSCPP----WF 233 L G A D WS GVILF+ L+GY PFSE L +I + +++ P Sbjct: 188 LVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEV 247 Query: 234 SAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRL-----NYVPIRAREEEEVNLDDIRA 286 S + L+ ++L +PK R + + PW + + + + E E + A Sbjct: 248 SEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDMKRKFQDLLSEENESTAKPQVLA 305 >5DYK-A nrPDB Length = 853 Score = 275 bits (703), Expect = 3e-74, Method: Composition-based stats. Identities = 96/301 (31%), Positives = 149/301 (49%), Gaps = 13/301 (4%) Query: 1 MTKKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREI 60 M + + E R IG GTF VK + T A+K ++K +I+ + IK E Sbjct: 531 MQDTKVEMDELETERIIGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLNQQNNIKLER 590 Query: 61 SIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVD 120 I HP I+RL Y + E VTGGEL+D I G L +S+++ Y ++ Sbjct: 591 EITAENDHPFIIRLVRTFKDSKYFYFLTELVTGGELYDAIRKLGLLSKSQAQFYLGSIIL 650 Query: 121 AVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEV 180 A+ + H + + +RDLKPEN+LLD G +K+ DFG + Q T GTP+Y+APEV Sbjct: 651 AIEYLHERNIVYRDLKPENILLDKQGYVKLIDFGCAKKVQG---RAYTLVGTPHYMAPEV 707 Query: 181 LSGQGYDGSAADIWSCGVILFVILAGYLPF--SETDLPGLYRKINAAEFSCPPWFSA-EV 237 + G+GY G DIW+ G+ L+ + G LPF E D ++R I + + P + + + Sbjct: 708 ILGKGY-GCTVDIWALGICLYEFICGPLPFGNDEEDQLEIFRDILTGQLTFPDYVTDTDS 766 Query: 238 KFLIHRILDPNPKTRI-----QIQGIKKDPWF-RLNYVPIRAREEEEVNLDDIRAVFDGI 291 L+ R+L P+ RI + IK P+F N+ + R + + + I Sbjct: 767 INLMKRLLCRLPQGRIGCSINGFKDIKDHPFFSNFNWDKLAGRLLDPPLVSKSETYAEDI 826 Query: 292 E 292 + Sbjct: 827 D 827 >3A8W-A nrPDB Length = 345 Score = 275 bits (703), Expect = 4e-74, Method: Composition-based stats. Identities = 86/311 (27%), Positives = 162/311 (52%), Gaps = 20/311 (6%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIV-RH 68 +++ R IG G++AKV R T A+K++ K + + +D ++ E + + H Sbjct: 10 DFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNH 69 Query: 69 PNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCK 128 P +V L+ + S+++ V+E+V GG+L + + +L E +R Y ++ A+ + H + Sbjct: 70 PFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHER 129 Query: 129 GVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDG 188 G+ +RDLK +N+LLD+ G++K++D+G+ + T CGTPNY+APE+L G+ Y G Sbjct: 130 GIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDY-G 188 Query: 189 SAADIWSCGVILFVILAGYLPFS---ETDLPG------LYRKINAAEFSCPPWFSAEVKF 239 + D W+ GV++F ++AG PF +D P L++ I + P S + Sbjct: 189 FSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAAS 248 Query: 240 LIHRILDPNPKTRI------QIQGIKKDPWFR-LNYVPIRAREEEEVNLDDIRAVF--DG 290 ++ L+ +PK R+ I+ P+FR +++ + ++ +I F D Sbjct: 249 VLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDN 308 Query: 291 IEGSYVAENVE 301 + + E V+ Sbjct: 309 FDSQFTNEPVQ 319 >4PDS-A nrPDB Length = 347 Score = 274 bits (702), Expect = 5e-74, Method: Composition-based stats. Identities = 87/273 (31%), Positives = 144/273 (52%), Gaps = 21/273 (7%) Query: 13 VGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIV 72 + +G+G FA VK A TG ++KI++K ++ N +D + RE+ +++ + HP IV Sbjct: 35 IDEVVGQGAFATVKKAIERTTGKTFSVKIISKRKVIGN--MDGVTRELEVLQKLNHPRIV 92 Query: 73 RLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYH 132 RL Y+V+EFV+GG+L D + G + E R+ +Q++ A+ + H G+ H Sbjct: 93 RLKGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSMGISH 152 Query: 133 RDLKPENLLLDTNGN--LKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQG----- 185 RDLKP+N+L++ + +K++ FGL+ Q ++T CGT YVAPEV+ G+ Sbjct: 153 RDLKPDNILIEQDDPVLVKITAFGLAK-VQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSP 211 Query: 186 -------YDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPP----WFS 234 S D+WS G +++VIL G+LPFS + LY++I + P S Sbjct: 212 DEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRGSYHEGPLKDFRIS 271 Query: 235 AEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLN 267 E + I +L +P R PW +++ Sbjct: 272 EEARDFIDSLLQVDPNNRSTAAKALNHPWIKMS 304 >6FD3-A nrPDB Length = 300 Score = 274 bits (701), Expect = 5e-74, Method: Composition-based stats. Identities = 74/261 (28%), Positives = 128/261 (49%), Gaps = 8/261 (3%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 KY IG+G V A + TG VAIK M K + I EI +M+ ++P Sbjct: 23 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKK---ELIINEILVMRENKNP 79 Query: 70 NIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKG 129 NIV + ++++V+E++ GG L D +V + ++E + ++ + A+ H Sbjct: 80 NIVNYLDSYLVGDELWVVMEYLAGGSLTD-VVTETCMDEGQIAAVCRECLQALDFLHSNQ 138 Query: 130 VYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGS 189 V HRD+K +N+LL +G++K++DFG A T GTP ++APEV++ + Y G Sbjct: 139 VIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAY-GP 197 Query: 190 AADIWSCGVILFVILAGYLPFSETDLPGLYRKI---NAAEFSCPPWFSAEVKFLIHRILD 246 DIWS G++ ++ G P+ + I E P SA + ++R L+ Sbjct: 198 KVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLE 257 Query: 247 PNPKTRIQIQGIKKDPWFRLN 267 + R + + + P+ +L+ Sbjct: 258 MDVDRRGSAKELLQHPFLKLD 278 >6AO5-A nrPDB Length = 362 Score = 274 bits (700), Expect = 7e-74, Method: Composition-based stats. Identities = 74/275 (26%), Positives = 132/275 (48%), Gaps = 13/275 (4%) Query: 1 MTKKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREI 60 +TK+ V ++V +GEG++ V A + ++G VAIK + + + +I +EI Sbjct: 4 LTKQPEEV--FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVES-----DLQEIIKEI 56 Query: 61 SIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIV-HKGRLEESESRKYFQQLV 119 SIM+ P +V+ Y + ++IV+E+ G + D I L E E + + Sbjct: 57 SIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTL 116 Query: 120 DAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPE 179 + + H HR++K N+LL+T G+ K++DFG++ + + T GTP ++APE Sbjct: 117 KGLEYLHFMRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPE 176 Query: 180 VLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAE---FSCPPWFSAE 236 V+ GY+ ADIWS G+ + G P+++ I F P +S + Sbjct: 177 VIQEIGYNCV-ADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDD 235 Query: 237 VKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVPI 271 + + L NP+ R + + P+ + N P+ Sbjct: 236 FTDFVKKCLVKNPEQRATATQLLQHPFIK-NAKPV 269 >5LOH-A nrPDB Length = 341 Score = 274 bits (700), Expect = 7e-74, Method: Composition-based stats. Identities = 82/305 (26%), Positives = 152/305 (49%), Gaps = 13/305 (4%) Query: 4 KMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIM 63 K + ++ + + I G F KV + G A+K++ K+ ++ M Q++ E + Sbjct: 31 KPPSIEEFSIVKPISRGAFGKVYLGQ--KGGKLYAVKVVKKADMINKNMTHQVQAERDAL 88 Query: 64 KIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVA 123 + + P IV LY L S + +Y+V+E++ GG++ + G +E + KY ++ A+ Sbjct: 89 ALSKSPFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALD 148 Query: 124 HCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSA------LPQEGVELLRTTCGTPNYVA 177 + H G+ HRDLKP+N+L+ G++K++DFGLS + + RT CGTP+Y+A Sbjct: 149 YLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILTTRTFCGTPDYLA 208 Query: 178 PEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCP---PWFS 234 PE+L G+ + G A D W+ GV LF L G PF++ +++ I + P S Sbjct: 209 PELLLGRAH-GPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKRDIPWPEGEEKLS 267 Query: 235 AEVKFLIHRILDPNPKTRIQIQGIKKDPWFR-LNYVPIRAREEEEVNLDDIRAVFDGIEG 293 + + +L + R ++ +K+ P F +++ ++ + + D E Sbjct: 268 DNAQSAVEILLTIDDTKRAGMKELKRHPLFSDVDWENLQHQTMPFIPQPDDETDTSYFEA 327 Query: 294 SYVAE 298 A+ Sbjct: 328 RNTAQ 332 >3UTO-A nrPDB Length = 573 Score = 273 bits (699), Expect = 1e-73, Method: Composition-based stats. Identities = 92/355 (25%), Positives = 163/355 (45%), Gaps = 18/355 (5%) Query: 3 KKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISI 62 K + Y++ +G G F V TG+N A K + + +++EI Sbjct: 151 KHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFV---MTPHESDKETVRKEIQT 207 Query: 63 MKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIV-HKGRLEESESRKYFQQLVDA 121 M ++RHP +V L++ +++ ++ EF++GGELF+++ ++ E E+ +Y +Q+ Sbjct: 208 MSVLRHPTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQVCKG 267 Query: 122 VAHCHCKGVYHRDLKPENLLLDTN--GNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPE 179 + H H H DLKPEN++ T LK+ DFGL+A + + ++ T GT + APE Sbjct: 268 LCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHL-DPKQSVKVTTGTAEFAAPE 326 Query: 180 VLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPP----WFSA 235 V G+ G D+WS GV+ +++L+G PF + R + + +++ S Sbjct: 327 VAEGKPV-GYYTDMWSVGVLSYILLSGLSPFGGENDDETLRNVKSCDWNMDDSAFSGISE 385 Query: 236 EVKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEVNLDDIRAVFDGIEGSY 295 + K I ++L +P TR+ I + PW P R + IR D I+ Y Sbjct: 386 DGKDFIRKLLLADPNTRMTIHQALEHPWLTPGNAPGRDSQIPSSRYTKIR---DSIKTKY 442 Query: 296 VAENVERNDEGPLMMNAFEMITLSQGLNLSALFDRRQDFVKRQTRFVSRREPSEI 350 A G + + Q ++ F R + Q RF+ + +E+ Sbjct: 443 DAWPEPLPPLGRISNYSSLRKHRPQEYSIRDAFWDRS---EAQPRFIVKPYGTEV 494 >2Y7J-A nrPDB Length = 365 Score = 273 bits (698), Expect = 1e-73, Method: Composition-based stats. Identities = 97/271 (35%), Positives = 143/271 (52%), Gaps = 16/271 (5%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIM-----AKSTILKNRMVDQIKREISIMK 64 KY+ IG G + V+ + TG A+KIM S + + +RE I++ Sbjct: 95 KYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHILR 154 Query: 65 IV-RHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVA 123 V HP+I+ L + S S +++V + + GELFD + K L E E+R + L++AV+ Sbjct: 155 QVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLEAVS 214 Query: 124 HCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVL-- 181 H + HRDLKPEN+LLD N +++SDFG S + G E LR CGTP Y+APE+L Sbjct: 215 FLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEPG-EKLRELCGTPGYLAPEILKC 273 Query: 182 ---SGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSC--PPWF--S 234 G D+W+CGVILF +LAG PF + R I ++ P W S Sbjct: 274 SMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFSSPEWDDRS 333 Query: 235 AEVKFLIHRILDPNPKTRIQIQGIKKDPWFR 265 + VK LI R+L +P+ R+ + + P+F Sbjct: 334 STVKDLISRLLQVDPEARLTAEQALQHPFFE 364 >4AF3-A nrPDB Length = 292 Score = 273 bits (698), Expect = 1e-73, Method: Composition-based stats. Identities = 90/260 (34%), Positives = 139/260 (53%), Gaps = 3/260 (1%) Query: 8 VGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR 67 + +E+GR +G+G F V AR + VA+K++ KS I K + Q++REI I + Sbjct: 22 IDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLH 81 Query: 68 HPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHC 127 HPNI+RLY +IY++LE+ GEL+ + +E + ++L DA+ +CH Sbjct: 82 HPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHG 141 Query: 128 KGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYD 187 K V HRD+KPENLLL G LK++DFG S +T CGT +Y+ PE++ G+ ++ Sbjct: 142 KKVIHRDIKPENLLLGLKGELKIADFGWS--VHAPSLRRKTMCGTLDYLPPEMIEGRMHN 199 Query: 188 GSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILDP 247 D+W GV+ + +L G PF YR+I + P + LI ++L Sbjct: 200 -EKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPTGAQDLISKLLRH 258 Query: 248 NPKTRIQIQGIKKDPWFRLN 267 NP R+ + + PW R N Sbjct: 259 NPSERLPLAQVSAHPWVRAN 278 >3I6U-A nrPDB Length = 419 Score = 273 bits (698), Expect = 1e-73, Method: Composition-based stats. Identities = 99/272 (36%), Positives = 149/272 (54%), Gaps = 17/272 (6%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQ-----IKREISIM 63 +Y + +T+G G +VK A T VAI+I++K + ++ EI I+ Sbjct: 135 DEYIMSKTLGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADPALNVETEIEIL 194 Query: 64 KIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVA 123 K + HP I+++ + YIVLE + GGELFD++V RL+E+ + YF Q++ AV Sbjct: 195 KKLNHPCIIKIKNFFDAEDY-YIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQ 253 Query: 124 HCHCKGVYHRDLKPENLLLD---TNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEV 180 + H G+ HRDLKPEN+LL + +K++DFG S + E L+RT CGTP Y+APEV Sbjct: 254 YLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGET-SLMRTLCGTPTYLAPEV 312 Query: 181 L--SGQGYDGSAADIWSCGVILFVILAGYLPFSET-DLPGLYRKINAAEFSCPP----WF 233 L G A D WS GVILF+ L+GY PFSE L +I + +++ P Sbjct: 313 LVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEV 372 Query: 234 SAEVKFLIHRILDPNPKTRIQIQGIKKDPWFR 265 S + L+ ++L +PK R + + PW + Sbjct: 373 SEKALDLVKKLLVVDPKARFTTEEALRHPWLQ 404 >1ZWS-A nrPDB Length = 288 Score = 272 bits (695), Expect = 3e-73, Method: Composition-based stats. Identities = 93/275 (33%), Positives = 149/275 (54%), Gaps = 13/275 (4%) Query: 3 KKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRM---VDQIKRE 59 K+ + Y++G +G G FA VK R TG A K + K +R ++I+RE Sbjct: 6 KQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIERE 65 Query: 60 ISIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLV 119 +SI++ V H N++ L++V + + + ++LE V+GGELFD + K L E E+ + +Q++ Sbjct: 66 VSILRQVLHHNVITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQIL 125 Query: 120 DAVAHCHCKGVYHRDLKPENL-LLDTN---GNLKVSDFGLSALPQEGVELLRTTCGTPNY 175 D V + H K + H DLKPEN+ LLD N ++K+ DFGL+ ++GVE + GTP + Sbjct: 126 DGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVE-FKNIFGTPEF 184 Query: 176 VAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWF-- 233 VAPE+++ + G AD+WS GVI +++L+G PF I + + F Sbjct: 185 VAPEIVNYEP-LGLEADMWSIGVITYILLSGASPFLGDTKQETLANITSVSYDFDEEFFS 243 Query: 234 --SAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRL 266 S K I ++L + R+ IQ + PW Sbjct: 244 HTSELAKDFIRKLLVKETRKRLTIQEALRHPWITP 278 >6BDL-A nrPDB Length = 347 Score = 272 bits (695), Expect = 3e-73, Method: Composition-based stats. Identities = 91/292 (31%), Positives = 146/292 (50%), Gaps = 11/292 (3%) Query: 7 RVGKYEVGRTIGEGTFAKVKFARNT-DTGDNVAIKIMAKSTILKNRMVDQIKREISIMKI 65 ++ + + T+G G F +V+ + + A+KI+ K I+ R + I+ E IM+ Sbjct: 32 KLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQG 91 Query: 66 VRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHC 125 IVRLY +Y+++E GGEL+ + +G E+S +R Y +V+A A+ Sbjct: 92 AHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYL 151 Query: 126 HCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQG 185 H KG+ +RDLKPENL+LD G K+ DFG + G + T CGTP YVAPE++ +G Sbjct: 152 HSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTW-TFCGTPEYVAPEIILNKG 210 Query: 186 YDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAA--EFSCPPWFSAEVKFLIHR 243 +D +AD WS G++++ +L G PFS D Y I P + LI + Sbjct: 211 HD-ISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKK 269 Query: 244 ILDPNPKTRI-----QIQGIKKDPWFR-LNYVPIRAREEEEVNLDDIRAVFD 289 + NP R+ ++ I+K WF N+ +R + + + D Sbjct: 270 LCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTD 321 >3TKU-A nrPDB Length = 433 Score = 271 bits (694), Expect = 4e-73, Method: Composition-based stats. Identities = 87/296 (29%), Positives = 141/296 (47%), Gaps = 18/296 (6%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 +E+ + IG G F +V + +T A+KI+ K +LK + E ++ Sbjct: 90 EDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDC 149 Query: 69 PNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVH-KGRLEESESRKYFQQLVDAVAHCHC 127 I L+ + +Y+V+++ GG+L + + +L E +R Y ++V A+ H Sbjct: 150 QWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQ 209 Query: 128 KGVYHRDLKPENLLLDTNGNLKVSDFGLS-ALPQEGVELLRTTCGTPNYVAPEVLS---- 182 HRD+KP+N+LLD NG+++++DFG + +G GTP+Y++PE+L Sbjct: 210 LHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAMED 269 Query: 183 GQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAE--FSCPPW---FSAEV 237 G G G D WS GV ++ +L G PF L Y KI E F P S E Sbjct: 270 GMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVTDVSEEA 329 Query: 238 KFLIHRILDPNPKTRI---QIQGIKKDPWFR-LNYVPIRAREEEEVNLDDIRAVFD 289 K LI R++ + R+ I+ KK +F LN+ IR E + D+ + D Sbjct: 330 KDLIQRLICSR-ERRLGQNGIEDFKKHAFFEGLNWENIRN--LEAPYIPDVSSPSD 382 >1PHK-A nrPDB Length = 298 Score = 271 bits (694), Expect = 4e-73, Method: Composition-based stats. Identities = 87/274 (31%), Positives = 137/274 (50%), Gaps = 17/274 (6%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAK------STILKNRMVDQIKREISI 62 YE +G G + V+ + T A+KI+ S + + +E+ I Sbjct: 17 ENYEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQELREATLKEVDI 76 Query: 63 MKIVR-HPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDA 121 ++ V HPNI++L + + + ++V + + GELFD + K L E E+RK + L++ Sbjct: 77 LRKVSGHPNIIQLKDTYETNTFFFLVFDLMKKGELFDYLTEKVTLSEKETRKIMRALLEV 136 Query: 122 VAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVL 181 + H + HRDLKPEN+LLD + N+K++DFG S G E LR CGTP+Y+APE++ Sbjct: 137 ICALHKLNIVHRDLKPENILLDDDMNIKLTDFGFSCQLDPG-EKLREVCGTPSYLAPEII 195 Query: 182 S-----GQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSC--PPW-- 232 G D+WS GVI++ +LAG PF + R I + + P W Sbjct: 196 ECSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFGSPEWDD 255 Query: 233 FSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRL 266 +S VK L+ R L P+ R + P+F+ Sbjct: 256 YSDTVKDLVSRFLVVQPQKRYTAEEALAHPFFQQ 289 >4C0T-A nrPDB Length = 974 Score = 271 bits (693), Expect = 5e-73, Method: Composition-based stats. Identities = 85/297 (28%), Positives = 151/297 (50%), Gaps = 15/297 (5%) Query: 1 MTKKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREI 60 M R V ++ G+ +GEG+++ V A + TG A+K++ K I+K + V + E Sbjct: 258 MKTIRRNVTDFKFGKELGEGSYSTVILATDKITGKQYAVKVLDKRHIIKEKKVKYVNIEK 317 Query: 61 SIMKIVRHP-NIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLV 119 + + + ++ LY +Y VL++ + GEL I L E +R + Q++ Sbjct: 318 HALNRLSNRLGVISLYFTFQDKDSLYFVLDYASNGELLTLIKRYNTLNEECTRHFGAQIL 377 Query: 120 DAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVE---------LLRTTC 170 DA+ + H GV HRDLKPEN+LLD ++++DFG + L ++ + ++ Sbjct: 378 DAIKYMHDNGVIHRDLKPENILLDDKMRIQITDFGTARLLEKKNDESEEYPVDVRAKSFV 437 Query: 171 GTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCP 230 GT YV+PE+L + Y G D+W+ G I++ ++AG PF T+ ++KI +F+ Sbjct: 438 GTAEYVSPELLENK-YCGKPGDVWAFGCIIYQMIAGKPPFKATNEYLTFQKITKLQFAFS 496 Query: 231 PWFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEVNLDDIRAV 287 F ++ LI +IL P R I I+K +F+ + ++ + + L D + Sbjct: 497 AGFPTIIRDLIKKILVLQPSRRATIPEIQKHYFFQS----VDFKDFDSIWLSDPPEI 549 >1KOA-A nrPDB Length = 491 Score = 271 bits (693), Expect = 5e-73, Method: Composition-based stats. Identities = 92/355 (25%), Positives = 163/355 (45%), Gaps = 18/355 (5%) Query: 3 KKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISI 62 K + Y++ +G G F V TG+N A K + + +++EI Sbjct: 45 KHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFV---MTPHESDKETVRKEIQT 101 Query: 63 MKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIV-HKGRLEESESRKYFQQLVDA 121 M ++RHP +V L++ +++ ++ EF++GGELF+++ ++ E E+ +Y +Q+ Sbjct: 102 MSVLRHPTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQVCKG 161 Query: 122 VAHCHCKGVYHRDLKPENLLLDTN--GNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPE 179 + H H H DLKPEN++ T LK+ DFGL+A + + ++ T GT + APE Sbjct: 162 LCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHL-DPKQSVKVTTGTAEFAAPE 220 Query: 180 VLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPP----WFSA 235 V G+ G D+WS GV+ +++L+G PF + R + + +++ S Sbjct: 221 VAEGKPV-GYYTDMWSVGVLSYILLSGLSPFGGENDDETLRNVKSCDWNMDDSAFSGISE 279 Query: 236 EVKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEVNLDDIRAVFDGIEGSY 295 + K I ++L +P TR+ I + PW P R + IR D I+ Y Sbjct: 280 DGKDFIRKLLLADPNTRMTIHQALEHPWLTPGNAPGRDSQIPSSRYTKIR---DSIKTKY 336 Query: 296 VAENVERNDEGPLMMNAFEMITLSQGLNLSALFDRRQDFVKRQTRFVSRREPSEI 350 A G + + Q ++ F R + Q RF+ + +E+ Sbjct: 337 DAWPEPLPPLGRISNYSSLRKHRPQEYSIRDAFWDRS---EAQPRFIVKPYGTEV 388 >3GUB-A nrPDB Length = 295 Score = 271 bits (693), Expect = 5e-73, Method: Composition-based stats. Identities = 90/269 (33%), Positives = 143/269 (53%), Gaps = 13/269 (4%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRM---VDQIKREISIMKI 65 Y+ G +G G FA VK R TG A K + K +R + I+RE+SI+K Sbjct: 11 DYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKE 70 Query: 66 VRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHC 125 ++HPN++ L+EV + + + ++ E V GGELFD + K L E E+ ++ +Q+++ V + Sbjct: 71 IQHPNVITLHEVYENKTDVILIGELVAGGELFDFLAEKESLTEEEATEFLKQILNGVYYL 130 Query: 126 HCKGVYHRDLKPENLLLDTNG----NLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVL 181 H + H DLKPEN++L +K+ DFGL+ G E + GTP +VAPE++ Sbjct: 131 HSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNE-FKNIFGTPEFVAPEIV 189 Query: 182 SGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWF----SAEV 237 + + G AD+WS GVI +++L+G PF ++A + + SA Sbjct: 190 NYEP-LGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFSNTSALA 248 Query: 238 KFLIHRILDPNPKTRIQIQGIKKDPWFRL 266 K I R+L +PK R+ IQ + PW + Sbjct: 249 KDFIRRLLVKDPKKRMTIQDSLQHPWIKP 277 >4AW2-A nrPDB Length = 437 Score = 270 bits (691), Expect = 7e-73, Method: Composition-based stats. Identities = 89/306 (29%), Positives = 146/306 (47%), Gaps = 20/306 (6%) Query: 3 KKMR-RVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREIS 61 K+MR +E+ + IG G F +V + + A+KI+ K +LK + E Sbjct: 67 KQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERD 126 Query: 62 IMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVH-KGRLEESESRKYFQQLVD 120 ++ I L+ + +Y+V+++ GG+L + + RL E +R Y ++V Sbjct: 127 VLVNGDSKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEEMARFYLAEMVI 186 Query: 121 AVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLS-ALPQEGVELLRTTCGTPNYVAPE 179 A+ H HRD+KP+N+L+D NG+++++DFG L ++G GTP+Y++PE Sbjct: 187 AIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPE 246 Query: 180 VLS----GQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKIN--AAEFSCP--- 230 +L G+G G D WS GV ++ +L G PF L Y KI F P Sbjct: 247 ILQAMEGGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPTQV 306 Query: 231 PWFSAEVKFLIHRILDPNPKTRI---QIQGIKKDPWFR-LNYVPIRARE---EEEVNLDD 283 S K LI R++ + R+ I+ KK P+F +++ IR E EV+ Sbjct: 307 TDVSENAKDLIRRLICSR-EHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPYIPEVSSPT 365 Query: 284 IRAVFD 289 + FD Sbjct: 366 DTSNFD 371 >4AGU-A nrPDB Length = 311 Score = 266 bits (681), Expect = 1e-71, Method: Composition-based stats. Identities = 73/289 (25%), Positives = 117/289 (40%), Gaps = 32/289 (11%) Query: 8 VGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR 67 + KYE IGEG++ V RN DTG VAIK +S + REI ++K ++ Sbjct: 2 MEKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESED-DPVIKKIALREIRMLKQLK 60 Query: 68 HPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHC 127 HPN+V L EV ++++V E+ L + ++ + E + Q + AV CH Sbjct: 61 HPNLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFCHK 120 Query: 128 KGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYD 187 HRD+KPEN+L+ + +K+ DFG + L + T Y +PE+L G Sbjct: 121 HNCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYDDEVATRWYRSPELLVGDTQY 180 Query: 188 GSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINA---------------------AE 226 G D+W+ G + +L+G + I + Sbjct: 181 GPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSGVK 240 Query: 227 FSCP----------PWFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFR 265 P P S L+ L +P R+ + + P+F Sbjct: 241 IPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTERLTCEQLLHHPYFE 289 >4QMW-A nrPDB Length = 310 Score = 266 bits (681), Expect = 1e-71, Method: Composition-based stats. Identities = 66/260 (25%), Positives = 120/260 (46%), Gaps = 5/260 (1%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 + IG+G+F +V + T VAIKI+ Q +EI+++ P Sbjct: 31 FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQ--QEITVLSQCDSPY 88 Query: 71 IVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGV 130 + + Y +K++I++E++ GG D ++ G L+E++ ++++ + + H + Sbjct: 89 VTKYYGSYLKDTKLWIIMEYLGGGSALD-LLEPGPLDETQIATILREILKGLDYLHSEKK 147 Query: 131 YHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSA 190 HRD+K N+LL +G +K++DFG++ + T GTP ++APEV+ YD Sbjct: 148 IHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDS-K 206 Query: 191 ADIWSCGVILFVILAGYLPFSETDLPGLYRKI-NAAEFSCPPWFSAEVKFLIHRILDPNP 249 ADIWS G+ + G P SE + I + +S +K + L+ P Sbjct: 207 ADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEP 266 Query: 250 KTRIQIQGIKKDPWFRLNYV 269 R + + K + N Sbjct: 267 SFRPTAKELLKHKFILRNAK 286 >3NYO-A nrPDB Length = 576 Score = 265 bits (679), Expect = 2e-71, Method: Composition-based stats. Identities = 78/290 (26%), Positives = 138/290 (47%), Gaps = 14/290 (4%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 + R +G+G F +V + TG A K + K I K + E I++ V Sbjct: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRF 245 Query: 71 IVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGR--LEESESRKYFQQLVDAVAHCHCK 128 +V L + + +VL + GG+L I H G+ E+ + Y ++ + H + Sbjct: 246 VVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRE 305 Query: 129 GVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDG 188 + +RDLKPEN+LLD +G++++SD GL+ EG + ++ GT Y+APEV+ + Y Sbjct: 306 RIVYRDLKPENILLDDHGHIRISDLGLAVHVPEG-QTIKGRVGTVGYMAPEVVKNERYTF 364 Query: 189 SAADIWSCGVILFVILAGYLPFSE----TDLPGLYRKINAAEFSCPPWFSAEVKFLIHRI 244 S D W+ G +L+ ++AG PF + + R + FS + + L ++ Sbjct: 365 SP-DWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQL 423 Query: 245 LDPNPKTRI-----QIQGIKKDPWF-RLNYVPIRAREEEEVNLDDIRAVF 288 L +P R+ + +K+ P F +LN+ + A E D +A++ Sbjct: 424 LCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIY 473 >2F57-A nrPDB Length = 317 Score = 265 bits (678), Expect = 3e-71, Method: Composition-based stats. Identities = 78/261 (29%), Positives = 133/261 (50%), Gaps = 14/261 (5%) Query: 16 TIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLY 75 IGEG+ V A TG VA+K M + K + + + E+ IM+ H N+V +Y Sbjct: 52 KIGEGSTGIVCIATEKHTGKQVAVKKMD---LRKQQRRELLFNEVVIMRDYHHDNVVDMY 108 Query: 76 EVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDL 135 ++++V+EF+ GG L D + H R+ E + ++ A+++ H +GV HRD+ Sbjct: 109 SSYLVGDELWVVMEFLEGGALTDIVTHT-RMNEEQIATVCLSVLRALSYLHNQGVIHRDI 167 Query: 136 KPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSAADIWS 195 K +++LL ++G +K+SDFG A + V ++ GTP ++APEV+S Y G+ DIWS Sbjct: 168 KSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPY-GTEVDIWS 226 Query: 196 CGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPW------FSAEVKFLIHRILDPNP 249 G+++ ++ G P+ R+I S PP S+ ++ + +L P Sbjct: 227 LGIMVIEMIDGEPPYFNEPPLQAMRRIRD---SLPPRVKDLHKVSSVLRGFLDLMLVREP 283 Query: 250 KTRIQIQGIKKDPWFRLNYVP 270 R Q + P+ +L P Sbjct: 284 SQRATAQELLGHPFLKLAGPP 304 >3KN6-A nrPDB Length = 325 Score = 265 bits (677), Expect = 3e-71, Method: Composition-based stats. Identities = 95/268 (35%), Positives = 149/268 (55%), Gaps = 22/268 (8%) Query: 15 RTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR-HPNIVR 73 + +GEG+F+ + + + A+KI++K RM ++EI+ +K+ HPNIV+ Sbjct: 17 KPLGEGSFSICRKCVHKKSNQAFAVKIISK------RMEANTQKEITALKLCEGHPNIVK 70 Query: 74 LYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHR 133 L+EV ++V+E + GGELF+RI K E+E+ ++LV AV+H H GV HR Sbjct: 71 LHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHR 130 Query: 134 DLKPENLLL---DTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSA 190 DLKPENLL + N +K+ DFG + L + L+T C T +Y APE+L+ GYD + Sbjct: 131 DLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYD-ES 189 Query: 191 ADIWSCGVILFVILAGYLPFSETDLP-------GLYRKINAAEFSCP----PWFSAEVKF 239 D+WS GVIL+ +L+G +PF D + +KI +FS S E K Sbjct: 190 CDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKD 249 Query: 240 LIHRILDPNPKTRIQIQGIKKDPWFRLN 267 LI +L +P R+++ G++ + W + Sbjct: 250 LIQGLLTVDPNKRLKMSGLRYNEWLQDG 277 >3NIZ-A nrPDB Length = 311 Score = 265 bits (677), Expect = 3e-71, Method: Composition-based stats. Identities = 86/289 (29%), Positives = 132/289 (45%), Gaps = 34/289 (11%) Query: 8 VGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR 67 + KY+ +GEGT+ V A+++ G VA+K + + I REIS++K + Sbjct: 20 MEKYQKLEKVGEGTYGVVYKAKDSQ-GRIVALKRIRLDAEDEGIPSTAI-REISLLKELH 77 Query: 68 HPNIVRLYEVLASPSKIYIVLEFVTGGELFDRI-VHKGRLEESESRKYFQQLVDAVAHCH 126 HPNIV L +V+ S + +V EF+ +L + +K L++S+ + Y QL+ VAHCH Sbjct: 78 HPNIVSLIDVIHSERCLTLVFEFMEK-DLKKVLDENKTGLQDSQIKIYLYQLLRGVAHCH 136 Query: 127 CKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGY 186 + HRDLKP+NLL++++G LK++DFGL+ V T Y AP+VL G Sbjct: 137 QHRILHRDLKPQNLLINSDGALKLADFGLARAFGIPVRSYTHEVVTLWYRAPDVLMGSKK 196 Query: 187 DGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKI------------------------ 222 ++ DIWS G I ++ G F KI Sbjct: 197 YSTSVDIWSIGCIFAEMITGKPLFPGVTDDDQLPKIFSILGTPNPREWPQVQELPLWKQR 256 Query: 223 ------NAAEFSCPPWFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFR 265 S P F E L+ +L +P RI + P+F+ Sbjct: 257 TFQVFEKKPWSSIIPGFCQEGIDLLSNMLCFDPNKRISARDAMNHPYFK 305 >4TNB-A nrPDB Length = 590 Score = 264 bits (676), Expect = 4e-71, Method: Composition-based stats. Identities = 84/290 (28%), Positives = 138/290 (47%), Gaps = 14/290 (4%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 + R +G+G F +V + TG A K + K I K + E I++ V Sbjct: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQF 245 Query: 71 IVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGR--LEESESRKYFQQLVDAVAHCHCK 128 +V L + + +VL + GG+L I + G EE + Y +++ + H + Sbjct: 246 VVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHHE 305 Query: 129 GVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDG 188 +RDLKPEN+LLD G++++SD GL+ EG +L+R GT Y+APEVL+ Q Y Sbjct: 306 NTVYRDLKPENILLDDYGHIRISDLGLAVKIPEG-DLIRGRVGTVGYMAPEVLNNQRYGL 364 Query: 189 SAADIWSCGVILFVILAGYLPFSETDL----PGLYRKINAAEFSCPPWFSAEVKFLIHRI 244 S D W G +++ ++ G PF + R++ E FS E K + + Sbjct: 365 SP-DYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKML 423 Query: 245 LDPNPKTRIQIQ-----GIKKDPWFR-LNYVPIRAREEEEVNLDDIRAVF 288 L + K R+ Q +K+ P+FR +N+ + A + + D RAV+ Sbjct: 424 LTKDAKQRLGCQEEEAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVY 473 >2UV2-A nrPDB Length = 325 Score = 264 bits (675), Expect = 7e-71, Method: Composition-based stats. Identities = 78/287 (27%), Positives = 140/287 (48%), Gaps = 14/287 (4%) Query: 1 MTKKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREI 60 +T+ + +E+ +G+G F KV A+N +T A K++ ++ EI Sbjct: 29 VTRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVID---TKSEEELEDYMVEI 85 Query: 61 SIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVH-KGRLEESESRKYFQQLV 119 I+ HPNIV+L + + ++I++EF GG + ++ + L ES+ + +Q + Sbjct: 86 DILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTL 145 Query: 120 DAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPE 179 DA+ + H + HRDLK N+L +G++K++DFG+SA ++ + GTP ++APE Sbjct: 146 DALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPE 205 Query: 180 VLS-----GQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSC---PP 231 V+ + YD AD+WS G+ L + P E + + KI +E P Sbjct: 206 VVMCETSKDRPYD-YKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPS 264 Query: 232 WFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLN-YVPIRAREEE 277 +S+ K + + L+ N R + + P+ ++ PIR E Sbjct: 265 RWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPIRELIAE 311 >3Q53-A nrPDB Length = 306 Score = 264 bits (674), Expect = 7e-71, Method: Composition-based stats. Identities = 71/260 (27%), Positives = 127/260 (48%), Gaps = 8/260 (3%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 KY IG+G V A + TG VAI+ M K + I EI +M+ ++P Sbjct: 22 KYTRFEKIGQGASGTVYTAMDVATGQEVAIRQMNLQQQPKK---ELIINEILVMRENKNP 78 Query: 70 NIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKG 129 NIV + ++++V+E++ GG L D +V + ++E + ++ + A+ H Sbjct: 79 NIVNYLDSYLVGDELWVVMEYLAGGSLTD-VVTETCMDEGQIAAVCRECLQALEFLHSNQ 137 Query: 130 VYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGS 189 V HRD+K +N+LL +G++K++DFG A T GTP ++APEV++ + Y G Sbjct: 138 VIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAY-GP 196 Query: 190 AADIWSCGVILFVILAGYLPFSETDLPGLYRKI---NAAEFSCPPWFSAEVKFLIHRILD 246 DIWS G++ ++ G P+ + I E P SA + ++R L+ Sbjct: 197 KVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLE 256 Query: 247 PNPKTRIQIQGIKKDPWFRL 266 + + R + + + + ++ Sbjct: 257 MDVEKRGSAKELIQHQFLKI 276 >4KS7-A nrPDB Length = 292 Score = 264 bits (674), Expect = 9e-71, Method: Composition-based stats. Identities = 74/258 (28%), Positives = 136/258 (52%), Gaps = 8/258 (3%) Query: 16 TIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLY 75 IGEG+ V AR +G VA+K+M + K + + + E+ IM+ +H N+V +Y Sbjct: 30 KIGEGSTGIVCLAREKHSGRQVAVKMMD---LRKQQRRELLFNEVVIMRDYQHFNVVEMY 86 Query: 76 EVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDL 135 + ++++++EF+ GG L D IV + RL E + + ++ A+A+ H +GV HRD+ Sbjct: 87 KSYLVGEELWVLMEFLQGGALTD-IVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDI 145 Query: 136 KPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSAADIWS 195 K +++LL +G +K+SDFG A + V ++ GTP ++APEV+S Y + DIWS Sbjct: 146 KSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLY-ATEVDIWS 204 Query: 196 CGVILFVILAGYLPFSETDLPGLYRKINA---AEFSCPPWFSAEVKFLIHRILDPNPKTR 252 G+++ ++ G P+ +++ + S ++ + R+L +P+ R Sbjct: 205 LGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQER 264 Query: 253 IQIQGIKKDPWFRLNYVP 270 Q + P+ +P Sbjct: 265 ATAQELLDHPFLLQTGLP 282 >5J5T-A nrPDB Length = 370 Score = 263 bits (672), Expect = 1e-70, Method: Composition-based stats. Identities = 78/294 (26%), Positives = 133/294 (45%), Gaps = 12/294 (4%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 +E+ + IG GT+ V ARN +TG+ AIK++ +++EI +MK +H Sbjct: 4 EDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEP---GEDFAVVQQEIIMMKDCKH 60 Query: 69 PNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCK 128 PNIV + K++I +EF GG L D G L E + ++ + + + H K Sbjct: 61 PNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSK 120 Query: 129 GVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEV--LSGQGY 186 G HRD+K N+LL NG++K++DFG+SA + + GTP ++APEV + +G Sbjct: 121 GKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKAFIGTPYWMAPEVAAVERKGG 180 Query: 187 DGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPP-----WFSAEVKFLI 241 D+W+ G+ + P + + + F P +S + Sbjct: 181 YNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFHHFV 240 Query: 242 HRILDPNPKTRIQIQGIKKDPWFRLNYVPIRARE-EEEVNLDDIRAVFDGIEGS 294 L NPK R + + + P+ + A E ++VN D + + + Sbjct: 241 KMALTKNPKKRPTAEKLLQHPFVTQHLTRSLAIELLDKVNNPD-HSTYHDFDDD 293 >4BBM-A nrPDB Length = 331 Score = 262 bits (669), Expect = 3e-70, Method: Composition-based stats. Identities = 84/310 (27%), Positives = 132/310 (42%), Gaps = 34/310 (10%) Query: 6 RRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQI-KREISIMK 64 + + KYE +GEG++ V RN DTG VAIK +S ++MV +I REI ++K Sbjct: 22 QSMEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESD--DDKMVKKIAMREIKLLK 79 Query: 65 IVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAH 124 +RH N+V L EV + Y+V EFV L D + L+ +KY Q+++ + Sbjct: 80 QLRHENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIGF 139 Query: 125 CHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQ 184 CH + HRD+KPEN+L+ +G +K+ DFG + E+ T Y APE+L G Sbjct: 140 CHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYDDEVATRWYRAPELLVGD 199 Query: 185 GYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAA------------------- 225 G A D+W+ G ++ + G F I Sbjct: 200 VKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFA 259 Query: 226 EFSCP------------PWFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVPIRA 273 P P S V L + L +P R + +F+++ R Sbjct: 260 GVRLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQMDGFAERF 319 Query: 274 REEEEVNLDD 283 +E ++ + Sbjct: 320 SQELQLKVQK 329 >4APC-A nrPDB Length = 350 Score = 262 bits (669), Expect = 3e-70, Method: Composition-based stats. Identities = 75/264 (28%), Positives = 142/264 (53%), Gaps = 9/264 (3%) Query: 6 RRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKI 65 + + KY + IGEG+F K ++T+ G IK + S + ++ ++ +RE++++ Sbjct: 21 QSMEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRM-SSKEREESRREVAVLAN 79 Query: 66 VRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGR--LEESESRKYFQQLVDAVA 123 ++HPNIV+ E +YIV+++ GG+LF RI + +E + +F Q+ A+ Sbjct: 80 MKHPNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALK 139 Query: 124 HCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSG 183 H H + + HRD+K +N+ L +G +++ DFG++ + VEL R GTP Y++PE+ Sbjct: 140 HVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARACIGTPYYLSPEICEN 199 Query: 184 QGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPP---WFSAEVKFL 240 + Y+ +DIW+ G +L+ + F + L KI + F PP +S +++ L Sbjct: 200 KPYNN-KSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSF--PPVSLHYSYDLRSL 256 Query: 241 IHRILDPNPKTRIQIQGIKKDPWF 264 + ++ NP+ R + I + + Sbjct: 257 VSQLFKRNPRDRPSVNSILEKGFI 280 >6CCF-A nrPDB Length = 290 Score = 260 bits (666), Expect = 6e-70, Method: Composition-based stats. Identities = 88/289 (30%), Positives = 151/289 (52%), Gaps = 30/289 (10%) Query: 7 RVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKI-----------MAKSTILKNRM--- 52 ++ +Y++ IG+G + V+ A N + A+K+ + + Sbjct: 3 QLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQ 62 Query: 53 ---------VDQIKREISIMKIVRHPNIVRLYEVLASP--SKIYIVLEFVTGGELFDRIV 101 ++++ +EI+I+K + H N+V+L EVL P +Y+V + + G + + Sbjct: 63 GGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEVPC 122 Query: 102 HKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQE 161 K E ++R Y + ++ + + HC+ + HRD+KP NLLL +G++K++DFG+S + Sbjct: 123 DK-PFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEG 181 Query: 162 GVELLRTTCGTPNYVAPEVL--SGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLY 219 L +T GTP ++APE + SGQ + G A D+W+ GV L+ + G PF + + L+ Sbjct: 182 NDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALH 241 Query: 220 RKINAAEFSCP--PWFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRL 266 RKI P P S E+K LI ++LD NP+TRI + IK PW Sbjct: 242 RKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTK 290 >3C51-A nrPDB Length = 543 Score = 260 bits (665), Expect = 8e-70, Method: Composition-based stats. Identities = 77/288 (26%), Positives = 136/288 (47%), Gaps = 15/288 (5%) Query: 15 RTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRL 74 R +G G F +V + TG A K + K + K + E I+ V IV L Sbjct: 191 RVLGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILAKVHSRFIVSL 250 Query: 75 YEVLASPSKIYIVLEFVTGGELFDRIVH----KGRLEESESRKYFQQLVDAVAHCHCKGV 130 + + + +V+ + GG++ I + +E + Y Q+V + H H + + Sbjct: 251 AYAFETKTDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQIVSGLEHLHQRNI 310 Query: 131 YHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSA 190 +RDLKPEN+LLD +GN+++SD GL+ + G + GTP ++APE+L G+ YD S Sbjct: 311 IYRDLKPENVLLDDDGNVRISDLGLAVELKAGQTKTKGYAGTPGFMAPELLLGEEYDFS- 369 Query: 191 ADIWSCGVILFVILAGYLPF----SETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILD 246 D ++ GV L+ ++A PF + + L +++ + P FS K +L Sbjct: 370 VDYFALGVTLYEMIAARGPFRARGEKVENKELKQRVLEQAVTYPDKFSPASKDFCEALLQ 429 Query: 247 PNPKTRIQIQG-----IKKDPWFR-LNYVPIRAREEEEVNLDDIRAVF 288 +P+ R+ + ++ P FR +++ + A + D R V+ Sbjct: 430 KDPEKRLGFRDGSCDGLRTHPLFRDISWRQLEAGMLTPPFVPDSRTVY 477 >2WQN-A nrPDB Length = 310 Score = 260 bits (665), Expect = 9e-70, Method: Composition-based stats. Identities = 75/260 (28%), Positives = 128/260 (49%), Gaps = 9/260 (3%) Query: 5 MRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMK 64 + + + + IG G F++V A G VA+K + ++ + +EI ++K Sbjct: 28 YNTLANFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLK 87 Query: 65 IVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVH----KGRLEESESRKYFQQLVD 120 + HPN+++ Y +++ IVLE G+L I H K + E KYF QL Sbjct: 88 QLNHPNVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCS 147 Query: 121 AVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEV 180 A+ H H + V HRD+KP N+ + G +K+ D GL + GTP Y++PE Sbjct: 148 ALEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPER 207 Query: 181 LSGQGYDGSAADIWSCGVILFVILAGYLPFSET--DLPGLYRKINAAEFSCPP--WFSAE 236 + GY+ +DIWS G +L+ + A PF +L L +KI ++ P +S E Sbjct: 208 IHENGYN-FKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEE 266 Query: 237 VKFLIHRILDPNPKTRIQIQ 256 ++ L++ ++P+P+ R + Sbjct: 267 LRQLVNMCINPDPEKRPDVT 286 >4FIE-A nrPDB Length = 423 Score = 259 bits (662), Expect = 2e-69, Method: Composition-based stats. Identities = 75/261 (28%), Positives = 128/261 (49%), Gaps = 14/261 (5%) Query: 16 TIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLY 75 IGEG+ V A +G VA+K M + K + + + E+ IM+ +H N+V +Y Sbjct: 158 KIGEGSTGIVCIATVRSSGKLVAVKKMD---LRKQQRRELLFNEVVIMRDYQHENVVEMY 214 Query: 76 EVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDL 135 ++++V+EF+ GG L D + H R+ E + ++ A++ H +GV HRD+ Sbjct: 215 NSYLVGDELWVVMEFLEGGALTDIVTHT-RMNEEQIAAVCLAVLQALSVLHAQGVIHRDI 273 Query: 136 KPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSAADIWS 195 K +++LL +G +K+SDFG A + V ++ GTP ++APE++S Y G DIWS Sbjct: 274 KSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPY-GPEVDIWS 332 Query: 196 CGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPW------FSAEVKFLIHRILDPNP 249 G+++ ++ G P+ + I PP S +K + R+L +P Sbjct: 333 LGIMVIEMVDGEPPYFNEPPLKAMKMIRDN---LPPRLKNLHKVSPSLKGFLDRLLVRDP 389 Query: 250 KTRIQIQGIKKDPWFRLNYVP 270 R + K P+ P Sbjct: 390 AQRATAAELLKHPFLAKAGPP 410 >4OTD-A nrPDB Length = 341 Score = 259 bits (661), Expect = 2e-69, Method: Composition-based stats. Identities = 93/318 (29%), Positives = 146/318 (45%), Gaps = 16/318 (5%) Query: 1 MTKKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREI 60 + K + ++ +G G F KV + +G+ AIK + K I+ V+ + E Sbjct: 4 LRKSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEK 63 Query: 61 SIMKIV---RHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQ 117 I+ V HP +V L+ +P + V+E+ GG+L I H E + Y Sbjct: 64 RILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHI-HSDVFSEPRAIFYSAC 122 Query: 118 LVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVA 177 +V + H + +RDLK +NLLLDT G +K++DFGL + T CGTP ++A Sbjct: 123 VVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLA 182 Query: 178 PEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEV 237 PEVL+ Y A D W GV+L+ +L G PF D ++ I E P + SAE Sbjct: 183 PEVLTDTSY-TRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEA 241 Query: 238 KFLIHRILDPNPKTRI-----QIQGIKKDPWFR-LNYVPIRAREEEEVNLDDIRAVFDGI 291 ++ R+L NP+ R+ + +KK P+FR L + + AR + + D Sbjct: 242 IGIMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDV- 300 Query: 292 EGSYVAENVERNDEGPLM 309 + E E P + Sbjct: 301 ----SNFDEEFTGEAPTL 314 >4WNO-A nrPDB Length = 287 Score = 258 bits (660), Expect = 3e-69, Method: Composition-based stats. Identities = 93/275 (33%), Positives = 140/275 (50%), Gaps = 19/275 (6%) Query: 5 MRRVGKYEVGRT--IGEGTFAKVKFARNTDTGD-NVAIKIMAKSTILKNRMVDQIKREIS 61 VGK+E R IG G FA V R+ D VA+K + K + K++ + + +EI Sbjct: 12 TETVGKFEFSRKDLIGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQTL--LGKEIK 69 Query: 62 IMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDA 121 I+K ++H NIV LY+ + +Y+V+E+ GG+L D + L E R + QQ+ A Sbjct: 70 ILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGA 129 Query: 122 VAHCHCKGVYHRDLKPENLLLDTNG---------NLKVSDFGLSALPQEGVELLRTTCGT 172 + H KG+ HRDLKP+N+LL +K++DFG + Q + + T CG+ Sbjct: 130 MRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNM-MAATLCGS 188 Query: 173 PNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGL---YRKINAAEFSC 229 P Y+APEV+ Q YDG AD+WS G I++ L G PF + L Y K + Sbjct: 189 PMYMAPEVIMSQHYDG-KADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPTI 247 Query: 230 PPWFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWF 264 P SA ++ L+ +L N K R+ P+ Sbjct: 248 PRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFL 282 >2X4F-A nrPDB Length = 373 Score = 258 bits (660), Expect = 3e-69, Method: Composition-based stats. Identities = 86/279 (30%), Positives = 143/279 (51%), Gaps = 14/279 (5%) Query: 11 YEVGRT--IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 Y V +T +G G F +V T TG +A KI+ + +++K EIS+M + H Sbjct: 89 YTVSKTEILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDK---EEVKNEISVMNQLDH 145 Query: 69 PNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKG-RLEESESRKYFQQLVDAVAHCHC 127 N+++LY+ S + I +V+E+V GGELFDRI+ + L E ++ + +Q+ + + H H Sbjct: 146 ANLIQLYDAFESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQ 205 Query: 128 KGVYHRDLKPENLL-LDTN-GNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQG 185 + H DLKPEN+L ++ + +K+ DFGL+ + E L+ GTP ++APEV++ Sbjct: 206 MYILHLDLKPENILCVNRDAKQIKIIDFGLARRYKP-REKLKVNFGTPEFLAPEVVNYD- 263 Query: 186 YDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPW----FSAEVKFLI 241 + D+WS GVI +++L+G PF + I A + S E K I Sbjct: 264 FVSFPTDMWSVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEFQDISEEAKEFI 323 Query: 242 HRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEVN 280 ++L RI K PW + + R +++ N Sbjct: 324 SKLLIKEKSWRISASEALKHPWLSDHKLHSRLSAQKKKN 362 >2XIK-A nrPDB Length = 294 Score = 258 bits (660), Expect = 3e-69, Method: Composition-based stats. Identities = 66/256 (25%), Positives = 118/256 (46%), Gaps = 5/256 (1%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 + IG+G+F +V + T + VAIKI+ Q +EI+++ P Sbjct: 21 FTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQ--QEITVLSQCDSPY 78 Query: 71 IVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGV 130 I R + +K++I++E++ GG D ++ G LEE+ ++++ + + H + Sbjct: 79 ITRYFGSYLKSTKLWIIMEYLGGGSALD-LLKPGPLEETYIATILREILKGLDYLHSERK 137 Query: 131 YHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSA 190 HRD+K N+LL G++K++DFG++ + T GTP ++APEV+ YD Sbjct: 138 IHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYD-FK 196 Query: 191 ADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPW-FSAEVKFLIHRILDPNP 249 ADIWS G+ + G P S+ + I S K + L+ +P Sbjct: 197 ADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQHSKPFKEFVEACLNKDP 256 Query: 250 KTRIQIQGIKKDPWFR 265 + R + + K + Sbjct: 257 RFRPTAKELLKHKFIT 272 >4JDH-A nrPDB Length = 346 Score = 258 bits (659), Expect = 4e-69, Method: Composition-based stats. Identities = 75/261 (28%), Positives = 128/261 (49%), Gaps = 14/261 (5%) Query: 16 TIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLY 75 IGEG+ V A +G VA+K M + K + + + E+ IM+ +H N+V +Y Sbjct: 81 KIGEGSTGIVCIATVRSSGKLVAVKKMD---LRKQQRRELLFNEVVIMRDYQHENVVEMY 137 Query: 76 EVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDL 135 ++++V+EF+ GG L D + H R+ E + ++ A++ H +GV HRD+ Sbjct: 138 NSYLVGDELWVVMEFLEGGALTDIVTHT-RMNEEQIAAVCLAVLQALSVLHAQGVIHRDI 196 Query: 136 KPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSAADIWS 195 K +++LL +G +K+SDFG A + V ++ GTP ++APE++S Y G DIWS Sbjct: 197 KSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPY-GPEVDIWS 255 Query: 196 CGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPW------FSAEVKFLIHRILDPNP 249 G+++ ++ G P+ + I PP S +K + R+L +P Sbjct: 256 LGIMVIEMVDGEPPYFNEPPLKAMKMIRDN---LPPRLKNLHKVSPSLKGFLDRLLVRDP 312 Query: 250 KTRIQIQGIKKDPWFRLNYVP 270 R + K P+ P Sbjct: 313 AQRATAAELLKHPFLAKAGPP 333 >6QAU-A nrPDB Length = 280 Score = 257 bits (658), Expect = 5e-69, Method: Composition-based stats. Identities = 90/278 (32%), Positives = 141/278 (50%), Gaps = 19/278 (6%) Query: 5 MRRVGKYEVGR--TIGEGTFAKVKFARNTD-TGDNVAIKIMAKSTILKNRMVDQIKREIS 61 M VG +E + +G G FA V R+ T VAIK + K + K++++ + +EI Sbjct: 5 MEVVGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQIL--LGKEIK 62 Query: 62 IMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDA 121 I+K ++H NIV LY+V P+ +++V+E+ GG+L D + KG L E R + Q+ A Sbjct: 63 ILKELQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAA 122 Query: 122 VAHCHCKGVYHRDLKPENLLLD---------TNGNLKVSDFGLSALPQEGVELLRTTCGT 172 + H KG+ HRDLKP+N+LL + +K++DFG + + + CG+ Sbjct: 123 MRILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNM-MAADLCGS 181 Query: 173 PNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGL---YRKINAAEFSC 229 P Y+APEV+ Q YD AD+WS G +++ L G PF L Y K + S Sbjct: 182 PMYMAPEVIMSQHYDA-KADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSI 240 Query: 230 PPWFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLN 267 P S + L+ +L N K R+ + P+ Sbjct: 241 PRETSPYLANLLLGLLQRNQKDRMDFEAFFSHPFLEQG 278 >4XBR-A nrPDB Length = 366 Score = 257 bits (658), Expect = 6e-69, Method: Composition-based stats. Identities = 75/261 (28%), Positives = 128/261 (49%), Gaps = 14/261 (5%) Query: 16 TIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLY 75 IGEG+ V A +G VA+K M + K + + + E+ IM+ +H N+V +Y Sbjct: 101 KIGEGSTGIVCIATVRSSGKLVAVKKMD---LRKQQRRELLFNEVVIMRDYQHENVVEMY 157 Query: 76 EVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDL 135 ++++V+EF+ GG L D + H R+ E + ++ A++ H +GV HRD+ Sbjct: 158 NSYLVGDELWVVMEFLEGGALTDIVTHT-RMNEEQIAAVCLAVLQALSVLHAQGVIHRDI 216 Query: 136 KPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSAADIWS 195 K +++LL +G +K+SDFG A + V ++ GTP ++APE++S Y G DIWS Sbjct: 217 KSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPY-GPEVDIWS 275 Query: 196 CGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPW------FSAEVKFLIHRILDPNP 249 G+++ ++ G P+ + I PP S +K + R+L +P Sbjct: 276 LGIMVIEMVDGEPPYFNEPPLKAMKMIRDN---LPPRLKNLHKVSPSLKGFLDRLLVRDP 332 Query: 250 KTRIQIQGIKKDPWFRLNYVP 270 R + K P+ P Sbjct: 333 AQRATAAELLKHPFLAKAGPP 353 >2Q0N-A nrPDB Length = 301 Score = 257 bits (658), Expect = 6e-69, Method: Composition-based stats. Identities = 75/261 (28%), Positives = 128/261 (49%), Gaps = 14/261 (5%) Query: 16 TIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLY 75 IGEG+ V A +G VA+K M + K + + + E+ IM+ +H N+V +Y Sbjct: 36 KIGEGSTGIVCIATVRSSGKLVAVKKMD---LRKQQRRELLFNEVVIMRDYQHENVVEMY 92 Query: 76 EVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDL 135 ++++V+EF+ GG L D + H R+ E + ++ A++ H +GV HRD+ Sbjct: 93 NSYLVGDELWVVMEFLEGGALTDIVTHT-RMNEEQIAAVCLAVLQALSVLHAQGVIHRDI 151 Query: 136 KPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSAADIWS 195 K +++LL +G +K+SDFG A + V ++ GTP ++APE++S Y G DIWS Sbjct: 152 KSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPY-GPEVDIWS 210 Query: 196 CGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPW------FSAEVKFLIHRILDPNP 249 G+++ ++ G P+ + I PP S +K + R+L +P Sbjct: 211 LGIMVIEMVDGEPPYFNEPPLKAMKMIRDN---LPPRLKNLHKVSPSLKGFLDRLLVRDP 267 Query: 250 KTRIQIQGIKKDPWFRLNYVP 270 R + K P+ P Sbjct: 268 AQRATAAELLKHPFLAKAGPP 288 >4FZF-B nrPDB Length = 283 Score = 257 bits (658), Expect = 6e-69, Method: Composition-based stats. Identities = 64/258 (24%), Positives = 116/258 (44%), Gaps = 5/258 (1%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 + IG+G+F +V + T VAIKI+ Q +EI+++ Sbjct: 10 FTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQ--QEITVLSQCDSSY 67 Query: 71 IVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGV 130 + + Y SK++I++E++ GG D ++ G +E + ++++ + + H + Sbjct: 68 VTKYYGSYLKGSKLWIIMEYLGGGSALD-LLRAGPFDEFQIATMLKEILKGLDYLHSEKK 126 Query: 131 YHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSA 190 HRD+K N+LL G++K++ FG++ + T GTP ++APEV+ YD Sbjct: 127 IHRDIKAANVLLSEQGDVKLAAFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDS-K 185 Query: 191 ADIWSCGVILFVILAGYLPFSETDLPGLYRKI-NAAEFSCPPWFSAEVKFLIHRILDPNP 249 ADIWS G+ + G P S+ + I + F+ K I L+ +P Sbjct: 186 ADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEFIDACLNKDP 245 Query: 250 KTRIQIQGIKKDPWFRLN 267 R + + K + N Sbjct: 246 SFRPTAKELLKHKFIVKN 263 >3IS5-A nrPDB Length = 285 Score = 257 bits (657), Expect = 6e-69, Method: Composition-based stats. Identities = 83/267 (31%), Positives = 132/267 (49%), Gaps = 17/267 (6%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 + R +G G F V +G IK + K ++QI+ EI ++K + HPN Sbjct: 24 FIFKRKLGSGAFGDVHLVEERSSGLERVIKTINKDR--SQVPMEQIEAEIEVLKSLDHPN 81 Query: 71 IVRLYEVLASPSKIYIVLEFVTGGELFDRIV----HKGRLEESESRKYFQQLVDAVAHCH 126 I++++EV +YIV+E GGEL +RIV L E + +Q+++A+A+ H Sbjct: 82 IIKIFEVFEDYHNMYIVMETCEGGELLERIVSAQARGKALSEGYVAELMKQMMNALAYFH 141 Query: 127 CKGVYHRDLKPENLLL---DTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSG 183 + V H+DLKPEN+L + +K+ DFGL+ L + E GT Y+APEV Sbjct: 142 SQHVVHKDLKPENILFQDTSPHSPIKIIDFGLAELFK-SDEHSTNAAGTALYMAPEVFKR 200 Query: 184 QGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAE----FSCPPWFSAEVKF 239 DIWS GV+++ +L G LPF+ T L + +K E C P + + Sbjct: 201 D--VTFKCDIWSAGVVMYFLLTGCLPFTGTSLEEVQQKATYKEPNYAVECRP-LTPQAVD 257 Query: 240 LIHRILDPNPKTRIQIQGIKKDPWFRL 266 L+ ++L +P+ R + WF+ Sbjct: 258 LLKQMLTKDPERRPSAAQVLHHEWFKQ 284 >4KRC-A nrPDB Length = 317 Score = 257 bits (657), Expect = 7e-69, Method: Composition-based stats. Identities = 84/300 (28%), Positives = 131/300 (43%), Gaps = 43/300 (14%) Query: 5 MRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMK 64 M +++ +G GT+A V N TG VA+K + + + REIS+MK Sbjct: 1 MSSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDS--EEGTPSTAIREISLMK 58 Query: 65 IVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHK------GRLEESESRKYFQQL 118 ++H NIVRLY+V+ + +K+ +V EF+ +L + + LE + + + QL Sbjct: 59 ELKHENIVRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQL 117 Query: 119 VDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAP 178 + +A CH + HRDLKP+NLL++ G LK+ DFGL+ V + T Y AP Sbjct: 118 LQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAP 177 Query: 179 EVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSC--------- 229 +VL G ++ DIWSCG IL ++ G F T+ + I + Sbjct: 178 DVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVT 237 Query: 230 ------------PPW-------------FSAEVKFLIHRILDPNPKTRIQIQGIKKDPWF 264 PP + +H +L NP R+ + PWF Sbjct: 238 KLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 >6GU6-A nrPDB Length = 302 Score = 257 bits (657), Expect = 8e-69, Method: Composition-based stats. Identities = 79/290 (27%), Positives = 125/290 (43%), Gaps = 34/290 (11%) Query: 8 VGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR 67 + Y IGEGT+ V R+ TG VA+K + + + I REIS++K +R Sbjct: 6 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAI-REISLLKELR 64 Query: 68 HPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGR---LEESESRKYFQQLVDAVAH 124 HPNIV L +VL S++Y++ EF++ +L + ++ S + Y Q++ + Sbjct: 65 HPNIVSLQDVLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVF 123 Query: 125 CHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQ 184 CH + V HRDLKP+NLL+D G +K++DFGL+ + + T Y +PEVL G Sbjct: 124 CHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGS 183 Query: 185 GYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKI------------------NAAE 226 + DIWS G I + F +I + Sbjct: 184 ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYK 243 Query: 227 FSCPPW-----------FSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFR 265 + P W L+ ++L +P RI + P+F Sbjct: 244 NTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFN 293 >2BRG-A nrPDB Length = 297 Score = 255 bits (653), Expect = 2e-68, Method: Composition-based stats. Identities = 100/266 (37%), Positives = 151/266 (56%), Gaps = 7/266 (2%) Query: 6 RRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKI 65 V +++ +T+GEG + +V+ A N T + VA+KI+ + + IK+EI I K+ Sbjct: 4 PFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVD--CPENIKKEICINKM 61 Query: 66 VRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHC 125 + H N+V+ Y + Y+ LE+ +GGELFDRI + E +++++F QL+ V + Sbjct: 62 LNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYL 121 Query: 126 HCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGV--ELLRTTCGTPNYVAPEVLSG 183 H G+ HRD+KPENLLLD NLK+SDFGL+ + + LL CGT YVAPE+L Sbjct: 122 HGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKR 181 Query: 184 QGYDGSAADIWSCGVILFVILAGYLPFSE-TDLPGLYRKINAAEFSCPPW--FSAEVKFL 240 + + D+WSCG++L +LAG LP+ + +D Y + PW + L Sbjct: 182 REFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLAL 241 Query: 241 IHRILDPNPKTRIQIQGIKKDPWFRL 266 +H+IL NP RI I IKKD W+ Sbjct: 242 LHKILVENPSARITIPDIKKDRWYNK 267 >6HXF-B nrPDB Length = 302 Score = 255 bits (653), Expect = 2e-68, Method: Composition-based stats. Identities = 76/263 (28%), Positives = 131/263 (49%), Gaps = 13/263 (4%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 +E+ +G+G F KV A+N +TG A K++ ++ EI I+ HP Sbjct: 21 WEIVGELGDGAFGKVYKAKNKETGALAAAKVI---ETKSEEELEDYIVEIEILATCDHPY 77 Query: 71 IVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGR-LEESESRKYFQQLVDAVAHCHCKG 129 IV+L K++I++EF GG + ++ R L E + + +Q+++A+ H K Sbjct: 78 IVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKR 137 Query: 130 VYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLS-----GQ 184 + HRDLK N+L+ G+++++DFG+SA + ++ + GTP ++APEV+ Sbjct: 138 IIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDT 197 Query: 185 GYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFS---CPPWFSAEVKFLI 241 YD ADIWS G+ L + P E + + KI ++ P +S E + + Sbjct: 198 PYD-YKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDFL 256 Query: 242 HRILDPNPKTRIQIQGIKKDPWF 264 LD NP+TR + + P+ Sbjct: 257 KIALDKNPETRPSAAQLLEHPFV 279 >3FXW-A nrPDB Length = 336 Score = 255 bits (652), Expect = 3e-68, Method: Composition-based stats. Identities = 86/309 (27%), Positives = 144/309 (46%), Gaps = 35/309 (11%) Query: 2 TKKMRRVGKYEVGR-TIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREI 60 KK Y++ + +G G KV + TG A+K++ S + + + Sbjct: 21 PKKYAVTDDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLLYDSPKARQEVDHHWQA-- 78 Query: 61 SIMKIVRHPNIVRLYEVLASPSK----IYIVLEFVTGGELFDRIVHKGR--LEESESRKY 114 P+IV + +V + + I++E + GGELF RI +G E E+ + Sbjct: 79 -----SGGPHIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEI 133 Query: 115 FQQLVDAVAHCHCKGVYHRDLKPENLLLDT---NGNLKVSDFGLSALPQEGVELLRTTCG 171 + + A+ H + HRD+KPENLL + + LK++DFG + + L+T C Sbjct: 134 MRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAK--ETTQNALQTPCY 191 Query: 172 TPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETD----LPGLYRKINAAEF 227 TP YVAPEVL + YD + D+WS GVI++++L G+ PF PG+ R+I ++ Sbjct: 192 TPYYVAPEVLGPEKYD-KSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQY 250 Query: 228 SCP----PWFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLNY-------VPIRAREE 276 P S + K LI +L +P R+ I PW + R +E Sbjct: 251 GFPNPEWSEVSEDAKQLIRLLLKTDPTERLTITQFMNHPWINQSMVVPQTPLHTARVLQE 310 Query: 277 EEVNLDDIR 285 ++ + D+++ Sbjct: 311 DKDHWDEVK 319 >5H2U-A nrPDB Length = 267 Score = 255 bits (651), Expect = 4e-68, Method: Composition-based stats. Identities = 68/256 (26%), Positives = 124/256 (48%), Gaps = 9/256 (3%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 ++ + R +G G F +V D VAIK++++ +L +M ++ EI MK +RH Sbjct: 6 EEFTLCRKLGSGYFGEVFEGLWKD-RVQVAIKVISRDNLLHQQM---LQSEIQAMKKLRH 61 Query: 69 PNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVH--KGRLEESESRKYFQQLVDAVAHCH 126 +I+ LY V++ +YI+ E + G L + + + L SE Q+ + + + Sbjct: 62 KHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLE 121 Query: 127 CKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGY 186 + HRDL N+L+ N KV DFGL+ L +E V L + APE LS +G+ Sbjct: 122 SQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALS-RGH 180 Query: 187 DGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAA-EFSCPPWFSAEVKFLIHRI 244 + +D+WS G++L + + G +P+ + +++A CP V L+ Sbjct: 181 YSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTC 240 Query: 245 LDPNPKTRIQIQGIKK 260 +P+ R + +++ Sbjct: 241 WCRDPEQRPTFKALRE 256 >2WTK-C nrPDB Length = 305 Score = 255 bits (651), Expect = 4e-68, Method: Composition-based stats. Identities = 89/301 (29%), Positives = 155/301 (51%), Gaps = 10/301 (3%) Query: 6 RRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILK-NRMVDQIKREISIMK 64 + +GKY +G +GEG++ KVK +++T A+KI+ K + + +K+EI +++ Sbjct: 2 KLIGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLR 61 Query: 65 IVRHPNIVRLYEVL--ASPSKIYIVLEFVTGG--ELFDRIVHKGRLEESESRKYFQQLVD 120 +RH N+++L +VL K+Y+V+E+ G E+ D + K R ++ YF QL+D Sbjct: 62 RLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEK-RFPVCQAHGYFCQLID 120 Query: 121 AVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQE--GVELLRTTCGTPNYVAP 178 + + H +G+ H+D+KP NLLL T G LK+S G++ + RT+ G+P + P Sbjct: 121 GLEYLHSQGIVHKDIKPGNLLLTTGGTLKISALGVAEALHPFAADDTCRTSQGSPAFQPP 180 Query: 179 EVLSG-QGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEV 237 E+ +G + G DIWS GV L+ I G PF ++ L+ I ++ P + Sbjct: 181 EIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPL 240 Query: 238 KFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEVNLDDIRAVFDGIEGSYVA 297 L+ +L+ P R I+ I++ WFR + P A + D + + + Sbjct: 241 SDLLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEAPVPIPPS-PDTKDRWRSMTVVPYL 299 Query: 298 E 298 E Sbjct: 300 E 300 >4AU8-A nrPDB Length = 296 Score = 254 bits (650), Expect = 5e-68, Method: Composition-based stats. Identities = 86/286 (30%), Positives = 129/286 (45%), Gaps = 33/286 (11%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 KYE IGEGT+ V A+N +T + VA+K + + REI ++K ++H Sbjct: 7 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDD-DEGVPSSALREICLLKELKHK 65 Query: 70 NIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHK-GRLEESESRKYFQQLVDAVAHCHCK 128 NIVRL++VL S K+ +V EF +L G L+ + + QL+ + CH + Sbjct: 66 NIVRLHDVLHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 124 Query: 129 GVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDG 188 V HRDLKP+NLL++ NG LK++DFGL+ V T Y P+VL G Sbjct: 125 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYS 184 Query: 189 SAADIWSCGVILFVIL-AGYLPFSETDLPGLYRKI-----NAAEFSCP------------ 230 ++ D+WS G I + AG F D+ ++I E P Sbjct: 185 TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYP 244 Query: 231 ------------PWFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWF 264 P +A + L+ +L NP RI + + P+F Sbjct: 245 MYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 290 >2FO0-A nrPDB Length = 495 Score = 254 bits (650), Expect = 5e-68, Method: Composition-based stats. Identities = 73/285 (25%), Positives = 117/285 (41%), Gaps = 19/285 (6%) Query: 9 GKYEVGR-------TIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREIS 61 K+E+ R +G G + +V VA+K + + T+ V++ +E + Sbjct: 210 DKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTM----EVEEFLKEAA 265 Query: 62 IMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGR--LEESESRKYFQQLV 119 +MK ++HPN+V+L V YI+ EF+T G L D + R + Q+ Sbjct: 266 VMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQIS 325 Query: 120 DAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTP-NYVAP 178 A+ + K HR+L N L+ N +KV+DFGLS L P + AP Sbjct: 326 SAMEYLEKKNFIHRNLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAP 385 Query: 179 EVLSGQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINA-AEFSCPPWFSAE 236 E L+ + +D+W+ GV+L+ I G P+ DL +Y + P + Sbjct: 386 ESLAYNKF-SIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEK 444 Query: 237 VKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEVNL 281 V L+ NP R I F + +E E L Sbjct: 445 VYELMRACWQWNPSDRPSFAEI--HQAFETMFQESSISDEVEKEL 487 >4XEY-B nrPDB Length = 408 Score = 254 bits (650), Expect = 5e-68, Method: Composition-based stats. Identities = 74/285 (25%), Positives = 117/285 (41%), Gaps = 19/285 (6%) Query: 9 GKYEVGR-------TIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREIS 61 K+E+ R +G G + +V VA+K + + T+ V++ +E + Sbjct: 118 DKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTM----EVEEFLKEAA 173 Query: 62 IMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGR--LEESESRKYFQQLV 119 +MK ++HPN+V+L V YI+ EF+T G L D + R + Q+ Sbjct: 174 VMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQIS 233 Query: 120 DAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTP-NYVAP 178 A+ + K HRDL N L+ N +KV+DFGLS L P + AP Sbjct: 234 SAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAP 293 Query: 179 EVLSGQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINA-AEFSCPPWFSAE 236 E L+ + +D+W+ GV+L+ I G P+ DL +Y + P + Sbjct: 294 ESLAYNKF-SIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEK 352 Query: 237 VKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEVNL 281 V L+ NP R I F + +E E L Sbjct: 353 VYELMRACWQWNPSDRPSFAEI--HQAFETMFQESSISDEVEKEL 395 >1KOB-A nrPDB Length = 387 Score = 254 bits (648), Expect = 7e-68, Method: Composition-based stats. Identities = 74/277 (26%), Positives = 134/277 (48%), Gaps = 12/277 (4%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 Y++ +G G F V TG K + L +K EISIM + H Sbjct: 51 DYYDILEELGSGAFGVVHRCVEKATGRVFVAKFINTPYPLDKYT---VKNEISIMNQLHH 107 Query: 69 PNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKG-RLEESESRKYFQQLVDAVAHCHC 127 P ++ L++ ++ ++LEF++GGELFDRI + ++ E+E Y +Q + + H H Sbjct: 108 PKLINLHDAFEDKYEMVLILEFLSGGELFDRIAAEDYKMSEAEVINYMRQACEGLKHMHE 167 Query: 128 KGVYHRDLKPENLLLDTN--GNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQG 185 + H D+KPEN++ +T ++K+ DFGL+ E+++ T T + APE++ + Sbjct: 168 HSIVHLDIKPENIMCETKKASSVKIIDFGLATKLNPD-EIVKVTTATAEFAAPEIVDREP 226 Query: 186 YDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPP----WFSAEVKFLI 241 G D+W+ GV+ +V+L+G PF+ D + + ++ S E K I Sbjct: 227 V-GFYTDMWAIGVLGYVLLSGLSPFAGEDDLETLQNVKRCDWEFDEDAFSSVSPEAKDFI 285 Query: 242 HRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEE 278 +L P+ R+ + + PW + ++ + +R Sbjct: 286 KNLLQKEPRKRLTVHDALEHPWLKGDHSNLTSRIPSS 322 >3PPZ-A nrPDB Length = 309 Score = 254 bits (648), Expect = 7e-68, Method: Composition-based stats. Identities = 75/279 (26%), Positives = 121/279 (43%), Gaps = 17/279 (6%) Query: 13 VGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIV 72 + IG G+F V A G +VA+KI+ + R V++ RE++IMK +RHPNIV Sbjct: 41 IKEKIGAGSFGTVHRAEWH--GSDVAVKILMEQDFHAER-VNEFLREVAIMKRLRHPNIV 97 Query: 73 RLYEVLASPSKIYIVLEFVTGGELFDRIVHKG---RLEESESRKYFQQLVDAVAHCHCKG 129 + P + IV E+++ G L+ + G +L+E + + + H + Sbjct: 98 LFMGAVTQPPNLSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGMNYLHNRN 157 Query: 130 --VYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYD 187 + HRDLK NLL+D +KV DFGLS L ++ GTP ++APEVL + Sbjct: 158 PPIVHRDLKSPNLLVDKKYTVKVCDFGLSRLKASTFLSSKSAAGTPEWMAPEVLRDEP-S 216 Query: 188 GSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINA--AEFSCPPWFSAEVKFLIHRIL 245 +D++S GVIL+ + P+ + + + P + +V +I Sbjct: 217 NEKSDVYSFGVILWELATLQQPWGNLNPAQVVAAVGFKCKRLEIPRNLNPQVAAIIEGCW 276 Query: 246 DPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEVNLDDI 284 P R I P+ N D+ Sbjct: 277 TNEPWKRPSFATIMD------LLRPLIKSAVPPPNRSDL 309 >3DAK-A nrPDB Length = 290 Score = 254 bits (648), Expect = 9e-68, Method: Composition-based stats. Identities = 73/283 (25%), Positives = 128/283 (45%), Gaps = 29/283 (10%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 YE+ IG G A V+ A + VAIK + + +D++ +EI M H Sbjct: 10 DDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTS--MDELLKEIQAMSQCHH 67 Query: 69 PNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVH--------KGRLEESESRKYFQQLVD 120 PNIV Y ++++V++ ++GG + D I H G L+ES +++++ Sbjct: 68 PNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLE 127 Query: 121 AVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELL-----RTTCGTPNY 175 + + H G HRD+K N+LL +G+++++DFG+SA G ++ +T GTP + Sbjct: 128 GLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCW 187 Query: 176 VAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFS------------ETDLPGLYRKIN 223 +APEV+ ADIWS G+ + G P+ + D P L + Sbjct: 188 MAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQ 247 Query: 224 AAEFSCPPWFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRL 266 E + + +I L +P+ R + + +F+ Sbjct: 248 DKEML--KKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQK 288 >2XYN-A nrPDB Length = 292 Score = 253 bits (647), Expect = 1e-67, Method: Composition-based stats. Identities = 67/264 (25%), Positives = 111/264 (42%), Gaps = 17/264 (6%) Query: 6 RRVGKYEVGR-------TIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKR 58 + + K+E+ R +G G + +V VA+K + + T+ V++ + Sbjct: 22 QSMDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTM----EVEEFLK 77 Query: 59 EISIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGR--LEESESRKYFQ 116 E ++MK ++HPN+V+L V YIV E++ G L D + R + Sbjct: 78 EAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMAT 137 Query: 117 QLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTP-NY 175 Q+ A+ + K HRDL N L+ N +KV+DFGLS L P + Sbjct: 138 QISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKW 197 Query: 176 VAPEVLSGQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAA-EFSCPPWF 233 APE L+ + +D+W+ GV+L+ I G P+ DL +Y + P Sbjct: 198 TAPESLAYNTF-SIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGC 256 Query: 234 SAEVKFLIHRILDPNPKTRIQIQG 257 +V L+ +P R Sbjct: 257 PPKVYELMRACWKWSPADRPSFAE 280 >4FR4-A nrPDB Length = 384 Score = 253 bits (646), Expect = 1e-67, Method: Composition-based stats. Identities = 73/283 (25%), Positives = 141/283 (49%), Gaps = 8/283 (2%) Query: 8 VGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR 67 +E+ R IG+G+F KV + DT A+K M K ++ V + +E+ IM+ + Sbjct: 14 FDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQGLE 73 Query: 68 HPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHC 127 HP +V L+ +++V++ + GG+L + +E + + +LV A+ + Sbjct: 74 HPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVMALDYLQN 133 Query: 128 KGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQG-- 185 + + HRD+KP+N+LLD +G++ ++DF ++A+ + + T GT Y+APE+ S + Sbjct: 134 QRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQ-ITTMAGTKPYMAPEMFSSRKGA 192 Query: 186 YDGSAADIWSCGVILFVILAGYLPF---SETDLPGLYRKINAAEFSCPPWFSAEVKFLIH 242 A D WS GV + +L G P+ S T + + P +S E+ L+ Sbjct: 193 GYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTFETTVVTYPSAWSQEMVSLLK 252 Query: 243 RILDPNPKTRIQ-IQGIKKDPWFR-LNYVPIRAREEEEVNLDD 283 ++L+PNP R + ++ P+ +N+ + + + + Sbjct: 253 KLLEPNPDQRFSQLSDVQNFPYMNDINWDAVFQKRLIPGFIPN 295 >4CRS-A nrPDB Length = 341 Score = 253 bits (646), Expect = 2e-67, Method: Composition-based stats. Identities = 89/300 (29%), Positives = 144/300 (48%), Gaps = 13/300 (4%) Query: 1 MTKKMRRVG--KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKR 58 M+++ + + + G F KV A +T + AIK + K I+ VD + Sbjct: 2 MSQQRFQFNLQDFRCCAVLLRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMC 61 Query: 59 EISI---MKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYF 115 E I + VRHP +V L+ + + V+E+ GG+L I H E + Y Sbjct: 62 EKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHI-HTDVFSEPRAVFYA 120 Query: 116 QQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNY 175 +V + + H + +RDLK +NLLLDT G +K++DFGL + T CGTP + Sbjct: 121 ACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEF 180 Query: 176 VAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSA 235 +APEVL+ Y A D W GV+++ +L G PF D ++ I E P + S Sbjct: 181 LAPEVLTETSY-TRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLST 239 Query: 236 EVKFLIHRILDPNPKTRI-----QIQGIKKDPWFRL-NYVPIRAREEEEVNLDDIRAVFD 289 E ++ R+L NP+ R+ + +KK P+FRL ++ + ++ + + IR D Sbjct: 240 EAISIMRRLLRRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGRED 299 >6BXI-A nrPDB Length = 333 Score = 252 bits (644), Expect = 2e-67, Method: Composition-based stats. Identities = 93/330 (28%), Positives = 153/330 (46%), Gaps = 48/330 (14%) Query: 8 VGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR 67 + +E + IG G F +V+ + DTG A+KI+ K+ +L+ V I+ E I+ Sbjct: 5 LEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEAD 64 Query: 68 HPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHC 127 +V+++ +Y+++EF+ GG++ ++ K L E E++ Y + V A+ H Sbjct: 65 SLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQ 124 Query: 128 KGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGV------------------------ 163 G HRD+KP+NLLLD+ G++K+SDFGL ++ Sbjct: 125 LGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSK 184 Query: 164 -----------ELLRTTCGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSE 212 +L +T GTP+Y+APEV GY+ D WS GVI++ +L GY PF Sbjct: 185 RKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYN-KLCDWWSLGVIMYEMLIGYPPFCS 243 Query: 213 TDLPGLYRKIN--AAEFSCPPW--FSAEVKFLIHRILDPNPKTR---IQIQGIKKDPWFR 265 Y+K+ + PP S + K LI R + R ++ IK + +F Sbjct: 244 ETPQETYKKVMNWKETLTFPPEVPISEKAKDLILRFCC-EWEHRIGAPGVEEIKSNSFFE 302 Query: 266 -LNYVPIRAREEE---EVNLDDIRAVFDGI 291 +++ IR R E+ D + FD Sbjct: 303 GVDWEHIRERPAAISIEIKSIDDTSNFDEF 332 >6NPU-A nrPDB Length = 298 Score = 251 bits (642), Expect = 3e-67, Method: Composition-based stats. Identities = 74/285 (25%), Positives = 117/285 (41%), Gaps = 19/285 (6%) Query: 9 GKYEVGR-------TIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREIS 61 K+E+ R +G G + +V VA+K + + T+ V++ +E + Sbjct: 19 DKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTM----EVEEFLKEAA 74 Query: 62 IMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGR--LEESESRKYFQQLV 119 +MK ++HPN+V+L V YI+ EF+T G L D + R + Q+ Sbjct: 75 VMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQIS 134 Query: 120 DAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTP-NYVAP 178 A+ + K HRDL N L+ N +KV+DFGLS L P + AP Sbjct: 135 SAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAP 194 Query: 179 EVLSGQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINA-AEFSCPPWFSAE 236 E L+ + +D+W+ GV+L+ I G P+ DL +Y + P + Sbjct: 195 ESLAYNKF-SIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEK 253 Query: 237 VKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEVNL 281 V L+ NP R I F + +E E L Sbjct: 254 VYELMRACWQWNPSDRPSFAEI--HQAFETMFQESSISDEVEKEL 296 >5D7A-A nrPDB Length = 308 Score = 251 bits (642), Expect = 4e-67, Method: Composition-based stats. Identities = 75/290 (25%), Positives = 129/290 (44%), Gaps = 19/290 (6%) Query: 8 VGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKI-V 66 G +E+ +G GT+ +V R+ TG AIK+M + ++IK+EI+++K Sbjct: 16 AGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMD----VTGDEEEEIKQEINMLKKYS 71 Query: 67 RHPNIVRLYEVLASPSK------IYIVLEFVTGGELFDRIVHK--GRLEESESRKYFQQL 118 H NI Y + +++V+EF G + D I + L+E +++ Sbjct: 72 HHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREI 131 Query: 119 VDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAP 178 + ++H H V HRD+K +N+LL N +K+ DFG+SA V T GTP ++AP Sbjct: 132 LRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 191 Query: 179 EVLSGQGY----DGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKI--NAAEFSCPPW 232 EV++ +D+WS G+ + G P + I N A Sbjct: 192 EVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKK 251 Query: 233 FSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEVNLD 282 +S + + I L N R + + K P+ R + R + + ++D Sbjct: 252 WSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHID 301 >2HW6-A nrPDB Length = 307 Score = 251 bits (642), Expect = 4e-67, Method: Composition-based stats. Identities = 79/296 (26%), Positives = 133/296 (44%), Gaps = 42/296 (14%) Query: 9 GKYE-----VGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIM 63 GK+E +GEG +AKV+ A + G A+KI+ K ++ RE+ + Sbjct: 8 GKFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQA---GHSRSRVFREVETL 64 Query: 64 KIVR-HPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAV 122 + + NI+ L E ++ Y+V E + GG + I + E E+ + + + A+ Sbjct: 65 YQCQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAAL 124 Query: 123 AHCHCKGVYHRDLKPENLLLDTN---GNLKVSDFGLSALPQEGVE-------LLRTTCGT 172 H KG+ HRDLKPEN+L ++ +K+ DF L + + L T CG+ Sbjct: 125 DFLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGS 184 Query: 173 PNYVAPEVLS----GQGYDGSAADIWSCGVILFVILAGYLPFSET--------------- 213 Y+APEV+ + D+WS GV+L+++L+GY PF Sbjct: 185 AEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRV 244 Query: 214 DLPGLYRKINAAEFSCPP----WFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFR 265 L+ I ++ P S+E K LI ++L + K R+ + + PW + Sbjct: 245 CQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQ 300 >2VD5-A nrPDB Length = 412 Score = 251 bits (641), Expect = 5e-67, Method: Composition-based stats. Identities = 84/298 (28%), Positives = 135/298 (45%), Gaps = 20/298 (6%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 +E+ + IG G F++V + TG A+KIM K +LK V + E ++ Sbjct: 61 DDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDR 120 Query: 69 PNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKG-RLEESESRKYFQQLVDAVAHCHC 127 I +L+ + +Y+V+E+ GG+L + G R+ +R Y ++V A+ H Sbjct: 121 RWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHR 180 Query: 128 KGVYHRDLKPENLLLDTNGNLKVSDFGLS-ALPQEGVELLRTTCGTPNYVAPEVLS---- 182 G HRD+KP+N+LLD G+++++DFG L +G GTP+Y++PE+L Sbjct: 181 LGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAVGG 240 Query: 183 --GQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKIN--AAEFSCP---PWFSA 235 G G G D W+ GV + + G PF Y KI S P Sbjct: 241 GPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDEGVPE 300 Query: 236 EVKFLIHRILDPNPKTRI---QIQGIKKDP-WFRLNYVPIRAREEEEVNLDDIRAVFD 289 E + I R+L P P+TR+ + P +F L++ +R + D D Sbjct: 301 EARDFIQRLLCP-PETRLGRGGAGDFRTHPFFFGLDWDGLR--DSVPPFTPDFEGATD 355 >3OHT-A nrPDB Length = 389 Score = 250 bits (640), Expect = 7e-67, Method: Composition-based stats. Identities = 63/311 (20%), Positives = 119/311 (38%), Gaps = 43/311 (13%) Query: 5 MRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMK 64 +Y+ +G G + V + + +G +A+K +++ + RE+ ++K Sbjct: 47 WEVPERYQTLSPVGSGAYGSVCSSYDVKSGLKIAVKKLSR-PFQSIIHAKRTYRELRLLK 105 Query: 65 IVRHPNIVRLYEVL------ASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQL 118 ++H N++ L +V + +Y+V + G + IV +L + + Q+ Sbjct: 106 HMKHENVIGLLDVFTPATSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQI 163 Query: 119 VDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAP 178 + + + H + HRDLKP NL ++ + LK+ DFGL+ + + T Y AP Sbjct: 164 LRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR---HTDDEMTGYVATRWYRAP 220 Query: 179 EVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWF----- 233 E++ + DIWS G I+ +L G F TD ++I + P Sbjct: 221 EIMLNWMHYNMTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPASVISRMP 280 Query: 234 --------------------------SAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLN 267 + L+ ++L + RI P+F Sbjct: 281 SHEARNYINSLPQMPKRNFADVFIGANPLAVDLLEKMLVLDTDKRITASEALAHPYFSQY 340 Query: 268 YVPIRAREEEE 278 + P E E Sbjct: 341 HDPDDEPESEP 351 >4EBW-A nrPDB Length = 304 Score = 250 bits (638), Expect = 1e-66, Method: Composition-based stats. Identities = 72/258 (27%), Positives = 122/258 (47%), Gaps = 11/258 (4%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDN---VAIKIMAKSTILKNRMVDQIKREISIMKI 65 + E+GR IGEG F V + VAIK T + + ++ +E M+ Sbjct: 38 ERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCT--SDSVREKFLQEALTMRQ 95 Query: 66 VRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRI-VHKGRLEESESRKYFQQLVDAVAH 124 HP+IV+L V+ + + ++I++E T GEL + V K L+ + Y QL A+A+ Sbjct: 96 FDHPHIVKLIGVI-TENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAY 154 Query: 125 CHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTP-NYVAPEVLSG 183 K HRD+ N+L+ +N +K+ DFGLS ++ + P ++APE ++ Sbjct: 155 LESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINF 214 Query: 184 QGYDGSAADIWSCGVILFVIL-AGYLPFSETDLPGLYRKINAAE-FSCPPWFSAEVKFLI 241 + + SA+D+W GV ++ IL G PF + +I E PP + L+ Sbjct: 215 RRF-TSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLM 273 Query: 242 HRILDPNPKTRIQIQGIK 259 + +P R + +K Sbjct: 274 TKCWAYDPSRRPRFTELK 291 >6E2O-A nrPDB Length = 295 Score = 248 bits (634), Expect = 4e-66, Method: Composition-based stats. Identities = 78/271 (28%), Positives = 123/271 (45%), Gaps = 16/271 (5%) Query: 10 KYEVGR-----TIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMK 64 YE +G+GT+ V R+ +AIK + + +R + EI++ K Sbjct: 18 DYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPER---DSRYSQPLHEEIALHK 74 Query: 65 IVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHK-GRL--EESESRKYFQQLVDA 121 ++H NIV+ + I I +E V GG L + K G L E Y +Q+++ Sbjct: 75 HLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEG 134 Query: 122 VAHCHCKGVYHRDLKPENLLLDT-NGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEV 180 + + H + HRD+K +N+L++T +G LK+SDFG S T GT Y+APE+ Sbjct: 135 LKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEI 194 Query: 181 L-SGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPG---LYRKINAAEFSCPPWFSAE 236 + G G AADIWS G + + G PF E P + P SAE Sbjct: 195 IDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAE 254 Query: 237 VKFLIHRILDPNPKTRIQIQGIKKDPWFRLN 267 K I + +P+P R + D + +++ Sbjct: 255 AKAFILKCFEPDPDKRACANDLLVDEFLKVS 285 >1NY3-A nrPDB Length = 400 Score = 248 bits (633), Expect = 4e-66, Method: Composition-based stats. Identities = 93/309 (30%), Positives = 149/309 (48%), Gaps = 36/309 (11%) Query: 3 KKMRRVGKYEV-GRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREIS 61 KK + Y+V + +G G KV N T + A+K++ + + +RE+ Sbjct: 55 KKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML--------QDCPKARREVE 106 Query: 62 IM-KIVRHPNIVRLYEVLAS----PSKIYIVLEFVTGGELFDRIVHKGR--LEESESRKY 114 + + + P+IVR+ +V + + IV+E + GGELF RI +G E E+ + Sbjct: 107 LHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEI 166 Query: 115 FQQLVDAVAHCHCKGVYHRDLKPENLLLDT---NGNLKVSDFGLSALPQEGVELLRTTCG 171 + + +A+ + H + HRD+KPENLL + N LK++DFG + L T C Sbjct: 167 MKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS-LTTPCY 225 Query: 172 TPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETD----LPGLYRKINAAEF 227 TP YVAPEVL + YD + D+WS GVI++++L GY PF PG+ +I ++ Sbjct: 226 TPYYVAPEVLGPEKYD-KSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQY 284 Query: 228 SCP----PWFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYV-------PIRAREE 276 P S EVK LI +L P R+ I PW + R +E Sbjct: 285 EFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKE 344 Query: 277 EEVNLDDIR 285 ++ +D++ Sbjct: 345 DKERWEDVK 353 >4YHJ-A nrPDB Length = 584 Score = 248 bits (633), Expect = 4e-66, Method: Composition-based stats. Identities = 78/290 (26%), Positives = 136/290 (46%), Gaps = 14/290 (4%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 + R +G+G F +V + TG A K + K I K + E I++ V+ Sbjct: 187 FRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSRF 246 Query: 71 IVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGR--LEESESRKYFQQLVDAVAHCHCK 128 +V L + + +VL + GG+L I + G +E + Y +L + + Sbjct: 247 VVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQRE 306 Query: 129 GVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDG 188 + +RDLKPEN+LLD G++++SD GL+ EG + +R GT Y+APEV++ + Y Sbjct: 307 RIVYRDLKPENILLDDRGHIRISDLGLATEIPEG-QRVRGRVGTVGYMAPEVVNNEKYTF 365 Query: 189 SAADIWSCGVILFVILAGYLPF----SETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRI 244 S D W G +++ ++ G+ PF + + ++I FS + K + + Sbjct: 366 SP-DWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSICRML 424 Query: 245 LDPNPKTRIQIQ-----GIKKDPWFR-LNYVPIRAREEEEVNLDDIRAVF 288 L NP R+ + G+K+ P F+ +N+ + A E D AV+ Sbjct: 425 LTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVY 474 >3KA0-A nrPDB Length = 320 Score = 247 bits (631), Expect = 7e-66, Method: Composition-based stats. Identities = 92/309 (29%), Positives = 148/309 (47%), Gaps = 36/309 (11%) Query: 3 KKMRRVGKYEV-GRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREIS 61 KK + Y+V + +G G KV N T + A+K++ + + +RE+ Sbjct: 9 KKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML--------QDCPKARREVE 60 Query: 62 IM-KIVRHPNIVRLYEVLAS----PSKIYIVLEFVTGGELFDRIVHKGR--LEESESRKY 114 + + + P+IVR+ +V + + IV+E + GGELF RI +G E E+ + Sbjct: 61 LHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEI 120 Query: 115 FQQLVDAVAHCHCKGVYHRDLKPENLLLDT---NGNLKVSDFGLSALPQEGVELLRTTCG 171 + + +A+ + H + HRD+KPENLL + N LK++DFG + L C Sbjct: 121 MKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS-LTEPCY 179 Query: 172 TPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETD----LPGLYRKINAAEF 227 TP YVAPEVL + YD + D+WS GVI++++L GY PF PG+ +I ++ Sbjct: 180 TPYYVAPEVLGPEKYD-KSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQY 238 Query: 228 SCP----PWFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYV-------PIRAREE 276 P S EVK LI +L P R+ I PW + R +E Sbjct: 239 EFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKE 298 Query: 277 EEVNLDDIR 285 ++ +D++ Sbjct: 299 DKERWEDVK 307 >2OZA-A nrPDB Length = 356 Score = 247 bits (631), Expect = 7e-66, Method: Composition-based stats. Identities = 93/309 (30%), Positives = 149/309 (48%), Gaps = 36/309 (11%) Query: 3 KKMRRVGKYEV-GRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREIS 61 KK + Y+V + +G G KV N T + A+K++ + + +RE+ Sbjct: 11 KKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML--------QDCPKARREVE 62 Query: 62 IM-KIVRHPNIVRLYEVLAS----PSKIYIVLEFVTGGELFDRIVHKGR--LEESESRKY 114 + + + P+IVR+ +V + + IV+E + GGELF RI +G E E+ + Sbjct: 63 LHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEI 122 Query: 115 FQQLVDAVAHCHCKGVYHRDLKPENLLLDT---NGNLKVSDFGLSALPQEGVELLRTTCG 171 + + +A+ + H + HRD+KPENLL + N LK++DFG + L T C Sbjct: 123 MKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS-LTTPCY 181 Query: 172 TPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETD----LPGLYRKINAAEF 227 TP YVAPEVL + YD + D+WS GVI++++L GY PF PG+ +I ++ Sbjct: 182 TPYYVAPEVLGPEKYD-KSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQY 240 Query: 228 SCP----PWFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYV-------PIRAREE 276 P S EVK LI +L P R+ I PW + R +E Sbjct: 241 EFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKE 300 Query: 277 EEVNLDDIR 285 ++ +D++ Sbjct: 301 DKERWEDVK 309 >3ZDU-A nrPDB Length = 325 Score = 247 bits (631), Expect = 8e-66, Method: Composition-based stats. Identities = 71/288 (24%), Positives = 114/288 (39%), Gaps = 33/288 (11%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 YE +GEG++ V ++ +TG VAIKI + + REI +K H N Sbjct: 5 YETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKI--AMREIKFLKQFHHEN 62 Query: 71 IVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGV 130 +V L EV KI++V EF+ L + + LE RKY Q++ A+ + H + Sbjct: 63 LVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSNNI 122 Query: 131 YHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSA 190 HRD+KPEN+L+ +G K+ DFG + ++ T Y APE++ G Sbjct: 123 IHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYDDEVATRWYRAPELVLKDTSYGKP 182 Query: 191 ADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWF----------------- 233 DIW+ G ++ + G + L KI + P Sbjct: 183 VDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVVLPQ 242 Query: 234 ---SAEVK-----------FLIHRILDPNPKTRIQIQGIKKDPWFRLN 267 + ++H L +P RI + +F + Sbjct: 243 VQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYFTRD 290 >5UUU-A nrPDB Length = 547 Score = 247 bits (631), Expect = 8e-66, Method: Composition-based stats. Identities = 81/287 (28%), Positives = 138/287 (48%), Gaps = 14/287 (4%) Query: 8 VGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIV- 66 + + V R IG G F +V R DTG A+K + K I + E ++ +V Sbjct: 197 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 256 Query: 67 --RHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAH 124 P IV + +P K+ +L+ + GG+L + G E++ R Y +++ + H Sbjct: 257 TGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEH 316 Query: 125 CHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQ 184 H + V +RDLKP N+LLD +G++++SD GL+ + + GT Y+APEVL Sbjct: 317 MHNRFVVYRDLKPANILLDEHGHVRISDLGLACDF--SKKKPHASVGTHGYMAPEVLQKG 374 Query: 185 GYDGSAADIWSCGVILFVILAGYLPFSET---DLPGLYRKINAAEFSCPPWFSAEVKFLI 241 S+AD +S G +LF +L G+ PF + D + R P FS E++ L+ Sbjct: 375 VAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLL 434 Query: 242 HRILDPNPKTRI-----QIQGIKKDPWFR-LNYVPIRAREEEEVNLD 282 +L + R+ Q +K+ P+FR L++ + ++ + Sbjct: 435 EGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIP 481 >1CM8-A nrPDB Length = 367 Score = 247 bits (630), Expect = 9e-66, Method: Composition-based stats. Identities = 70/331 (21%), Positives = 127/331 (38%), Gaps = 45/331 (13%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 Y + +G G + V A + TG VAIK + + + RE+ ++K +RH N Sbjct: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYR-PFQSELFAKRAYRELRLLKHMRHEN 85 Query: 71 IVRLYEVLASPSKI------YIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAH 124 ++ L +V + Y+V+ F+ G +++ +L E + Q++ + + Sbjct: 86 VIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRY 143 Query: 125 CHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQ 184 H G+ HRDLKP NL ++ + LK+ DFGL+ + T Y APEV+ Sbjct: 144 IHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQ---ADSEMTGYVVTRWYRAPEVILNW 200 Query: 185 GYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWF----------- 233 DIWS G I+ ++ G F +D ++I + P F Sbjct: 201 MRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKN 260 Query: 234 --------------------SAEVKFLIHRILDPNPKTRIQIQGIKKDPWFR--LNYVPI 271 S L+ ++L + + R+ P+F + Sbjct: 261 YMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDE 320 Query: 272 RAREEEEVNLDDIRAVFDGIEGSYVAENVER 302 ++ + + DD+ D + E + Sbjct: 321 PQVQKYDDSFDDVDRTLDEWKRVTYKEVLSF 351 >2H8H-A nrPDB Length = 535 Score = 247 bits (630), Expect = 1e-65, Method: Composition-based stats. Identities = 63/246 (25%), Positives = 108/246 (43%), Gaps = 12/246 (4%) Query: 16 TIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLY 75 +G+G F +V T VAIK + T+ + +E +MK +RH +V+LY Sbjct: 274 KLGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMSP----EAFLQEAQVMKKLRHEKLVQLY 328 Query: 76 EVLASPSKIYIVLEFVTGGELFDRIVHK--GRLEESESRKYFQQLVDAVAHCHCKGVYHR 133 V++ IYIV E+++ G L D + + L + Q+ +A+ HR Sbjct: 329 AVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHR 387 Query: 134 DLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTP-NYVAPEVLSGQGYDGSAAD 192 DL+ N+L+ N KV+DFGL+ L ++ R P + APE G +D Sbjct: 388 DLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALY-GRFTIKSD 446 Query: 193 IWSCGVILFVILA-GYLPFSETDLPGLYRKINAA-EFSCPPWFSAEVKFLIHRILDPNPK 250 +WS G++L + G +P+ + ++ CPP + L+ + P+ Sbjct: 447 VWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPE 506 Query: 251 TRIQIQ 256 R + Sbjct: 507 ERPTFE 512 >2F9G-A nrPDB Length = 353 Score = 246 bits (629), Expect = 1e-65, Method: Composition-based stats. Identities = 77/318 (24%), Positives = 126/318 (39%), Gaps = 51/318 (16%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 +++ +GEG + V A + TG+ VAIK + K + REI I+K +H Sbjct: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI--EPFDKPLFALRTLREIKILKHFKH 68 Query: 69 PNIVRLY-----EVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVA 123 NI+ ++ + + +++YI+ E + R++ L + + + Q + AV Sbjct: 69 ENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVK 126 Query: 124 HCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEG----------VELLRTTCGTP 173 H V HRDLKP NLL+++N +LKV DFGL+ + E + T Sbjct: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 Query: 174 NYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETD------------------- 214 Y APEV+ A D+WSCG IL + F D Sbjct: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDN 246 Query: 215 ------LPGLYRKINAAEF-------SCPPWFSAEVKFLIHRILDPNPKTRIQIQGIKKD 261 P I + P + + L+ R+L +P RI + + Sbjct: 247 DLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEH 306 Query: 262 PWFRLNYVPIRAREEEEV 279 P+ + + P E E + Sbjct: 307 PYLQTYHDPNDEPEGEPI 324 >1V0B-A nrPDB Length = 288 Score = 246 bits (628), Expect = 2e-65, Method: Composition-based stats. Identities = 83/290 (28%), Positives = 133/290 (45%), Gaps = 33/290 (11%) Query: 8 VGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR 67 + KY IGEGT+ V A+N + G+ A+K + + I REISI+K ++ Sbjct: 1 MEKYHGLEKIGEGTYGVVYKAQN-NYGETFALKKIRLEKEDEGIPSTTI-REISILKELK 58 Query: 68 HPNIVRLYEVLASPSKIYIVLEFVTGGELFDRI-VHKGRLEESESRKYFQQLVDAVAHCH 126 H NIV+LY+V+ + ++ +V E + +L + V +G LE ++ + QL++ +A+CH Sbjct: 59 HSNIVKLYDVIHTKKRLVLVFEHLDQ-DLKKLLDVCEGGLESVTAKSFLLQLLNGIAYCH 117 Query: 127 CKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGY 186 + V HRDLKP+NLL++ G LK++DFGL+ V T Y AP+VL G Sbjct: 118 DRRVLHRDLKPQNLLINREGELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVLMGSKK 177 Query: 187 DGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKI-----------------------N 223 + DIWS G I ++ G F +I N Sbjct: 178 YSTTIDIWSVGCIFAEMVNGAPLFPGVSEADQLMRIFRILGTPNSKNWPNVTELPKYDPN 237 Query: 224 AAEFSCPPW------FSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLN 267 + PW L+ ++L +P RI + + +F+ N Sbjct: 238 FTVYEPLPWESFLKGLDESGIDLLSKMLKLDPNQRITAKQALEHAYFKEN 287 >4EWQ-A nrPDB Length = 383 Score = 246 bits (628), Expect = 2e-65, Method: Composition-based stats. Identities = 63/311 (20%), Positives = 116/311 (37%), Gaps = 43/311 (13%) Query: 5 MRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMK 64 +Y+ +G G + V A +T TG VA+K +++ + RE+ ++K Sbjct: 41 WEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSR-PFQSIIHAKRTYRELRLLK 99 Query: 65 IVRHPNIVRLYEVL------ASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQL 118 ++H N++ L +V + +Y+V + G + IV +L + + Q+ Sbjct: 100 HMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQI 157 Query: 119 VDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAP 178 + + + H + HRDLKP NL ++ + LK+ DFGL+ + + T Y AP Sbjct: 158 LRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR---HTDDEMTGYVATRWYRAP 214 Query: 179 EVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWF----- 233 E++ + DIWS G I+ +L G F TD + I + Sbjct: 215 EIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKIS 274 Query: 234 --------------------------SAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLN 267 + L+ ++L + RI +F Sbjct: 275 SESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQY 334 Query: 268 YVPIRAREEEE 278 + P + Sbjct: 335 HDPDDEPVADP 345 >4P5Q-A nrPDB Length = 361 Score = 245 bits (627), Expect = 2e-65, Method: Composition-based stats. Identities = 66/255 (25%), Positives = 114/255 (44%), Gaps = 12/255 (4%) Query: 13 VGRTIGEGTFAKVKFARNTDTGDN---VAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 + + +G G F +V R VAIK + K R E SIM HP Sbjct: 37 IDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQR--RDFLGEASIMGQFDHP 94 Query: 70 NIVRLYEVLASPSKIYIVLEFVTGGELFDRIV-HKGRLEESESRKYFQQLVDAVAHCHCK 128 NI+RL V+ + IV E++ G L + H + + + + + + Sbjct: 95 NIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYLSDM 154 Query: 129 GVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCG---TPNYVAPEVLSGQG 185 G HRDL N+L+++N KVSDFGLS + ++ E TT G + +PE ++ + Sbjct: 155 GYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIAYRK 214 Query: 186 YDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAAEFSCPP-WFSAEVKFLIHR 243 + SA+D+WS G++L+ +++ G P+ E + + ++ PP A + L+ Sbjct: 215 F-TSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCPAALYQLMLD 273 Query: 244 ILDPNPKTRIQIQGI 258 + R + + I Sbjct: 274 CWQKDRNNRPKFEQI 288 >3PVW-A nrPDB Length = 695 Score = 245 bits (627), Expect = 2e-65, Method: Composition-based stats. Identities = 81/287 (28%), Positives = 138/287 (48%), Gaps = 14/287 (4%) Query: 8 VGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIV- 66 + + V R IG G F +V R DTG A+K + K I + E ++ +V Sbjct: 188 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 247 Query: 67 --RHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAH 124 P IV + +P K+ +L+ + GG+L + G E++ R Y +++ + H Sbjct: 248 TGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEH 307 Query: 125 CHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQ 184 H + V +RDLKP N+LLD +G++++SD GL+ + + GT Y+APEVL Sbjct: 308 MHNRFVVYRDLKPANILLDEHGHVRISDLGLACDF--SKKKPHASVGTHGYMAPEVLQKG 365 Query: 185 GYDGSAADIWSCGVILFVILAGYLPFSET---DLPGLYRKINAAEFSCPPWFSAEVKFLI 241 S+AD +S G +LF +L G+ PF + D + R P FS E++ L+ Sbjct: 366 VAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLL 425 Query: 242 HRILDPNPKTRI-----QIQGIKKDPWFR-LNYVPIRAREEEEVNLD 282 +L + R+ Q +K+ P+FR L++ + ++ + Sbjct: 426 EGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIP 472 >3DKO-A nrPDB Length = 318 Score = 245 bits (627), Expect = 2e-65, Method: Composition-based stats. Identities = 69/260 (26%), Positives = 114/260 (43%), Gaps = 12/260 (4%) Query: 8 VGKYEVGRTIGEGTFAKVKFARNTDTGDN---VAIKIMAKSTILKNRMVDQIKREISIMK 64 ++ R IG G F +V R G VAIK + K R E SIM Sbjct: 42 ASCIKIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQR--RDFLCEASIMG 99 Query: 65 IVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIV-HKGRLEESESRKYFQQLVDAVA 123 HPN+V L V+ + IV+EF+ G L + H G+ + + + + Sbjct: 100 QFDHPNVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGMR 159 Query: 124 HCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCG---TPNYVAPEV 180 + G HRDL N+L+++N KVSDFGLS + ++ E + TT G + APE Sbjct: 160 YLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEA 219 Query: 181 LSGQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAA-EFSCPPWFSAEVK 238 + + + SA+D+WS G++++ +++ G P+ + + + I P A + Sbjct: 220 IQYRKF-TSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPAPMDCPAGLH 278 Query: 239 FLIHRILDPNPKTRIQIQGI 258 L+ R + + I Sbjct: 279 QLMLDCWQKERAERPKFEQI 298 >5DBX-A nrPDB Length = 328 Score = 245 bits (627), Expect = 2e-65, Method: Composition-based stats. Identities = 74/299 (24%), Positives = 129/299 (43%), Gaps = 29/299 (9%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 YE+ IG G A V+ A + VAIK + + +D++ +EI M HPN Sbjct: 13 YELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTS--MDELLKEIQAMSQCSHPN 70 Query: 71 IVRLYEVLASPSKIYIVLEFVTGGELFDRIV--------HKGRLEESESRKYFQQLVDAV 122 +V Y ++++V++ ++GG + D I G LEE+ +++++ + Sbjct: 71 VVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGL 130 Query: 123 AHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELL-----RTTCGTPNYVA 177 + H G HRDLK N+LL +G+++++DFG+SA G ++ + GTP ++A Sbjct: 131 DYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKDFVGTPCWMA 190 Query: 178 PEVLSGQGYDGSAADIWSCGVILFVILAGYLPFS------------ETDLPGLYRKINAA 225 PEV+ AD+WS G+ + G P+ + D P L + Sbjct: 191 PEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLETGVEDK 250 Query: 226 EFSCPPWFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEVNLDDI 284 E + + L+ L +P R + K +F+ E+ DI Sbjct: 251 EMM--KKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQKAKNREYLIEKLLTRTPDI 307 >4IC8-A nrPDB Length = 442 Score = 245 bits (625), Expect = 3e-65, Method: Composition-based stats. Identities = 80/341 (23%), Positives = 128/341 (37%), Gaps = 46/341 (13%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 +YE+ TIG G + V AR TG VAIK + + + + RE+ I+K +H Sbjct: 55 DEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDV-VTNAKRTLRELKILKHFKH 113 Query: 69 PNIVRLYEV------LASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAV 122 NI+ + ++ +Y+VL+ + +L I L R + QL+ + Sbjct: 114 DNIIAIKDILRPTVPYGEFKSVYVVLDLME-SDLHQIIHSSQPLTLEHVRYFLYQLLRGL 172 Query: 123 AHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSA----LPQEGVELLRTTCGTPNYVAP 178 + H V HRDLKP NLL++ N LK+ DFG++ P E + T Y AP Sbjct: 173 KYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAP 232 Query: 179 EVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETD------------------------ 214 E++ A D+WS G I +LA F + Sbjct: 233 ELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVG 292 Query: 215 LPGLYRKINAAEFSCP-------PWFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLN 267 + I + P P + L+ R+L P RI + P+ Sbjct: 293 AERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKY 352 Query: 268 YVPIRAREEEEVN---LDDIRAVFDGIEGSYVAENVERNDE 305 + P + D + I+ + VAE + + Sbjct: 353 HDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFHAR 393 >4XCU-A nrPDB Length = 300 Score = 244 bits (624), Expect = 5e-65, Method: Composition-based stats. Identities = 60/271 (22%), Positives = 115/271 (42%), Gaps = 22/271 (8%) Query: 9 GKYEVGRTIGEGTFAKVKFAR-------NTDTGDNVAIKIMAKSTILKNRMVDQIKREIS 61 + +G+ +GEG F +V A D VA+K++ + ++ + + E+ Sbjct: 17 DRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNA--SDKDLADLVSEME 74 Query: 62 IMKIV-RHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHK-------GRLEESESRK 113 +MK++ RH NI+ L V +Y+++E G L + + + G L Sbjct: 75 VMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGSSEGPLSFPVLVS 134 Query: 114 YFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCG-- 171 Q+ + + + HRDL N+L+ + +K++DFGL+ +T+ G Sbjct: 135 CAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRL 194 Query: 172 TPNYVAPEVLSGQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAA-EFSC 229 ++APE L + Y +D+WS G++L+ I G P+ + L+ + Sbjct: 195 PVKWMAPEALFDRVY-THQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDR 253 Query: 230 PPWFSAEVKFLIHRILDPNPKTRIQIQGIKK 260 PP E+ L+ P R + + + Sbjct: 254 PPHCPPELYGLMRECWHAAPSQRPTFKQLVE 284 >4LQP-A nrPDB Length = 508 Score = 244 bits (624), Expect = 5e-65, Method: Composition-based stats. Identities = 80/350 (22%), Positives = 141/350 (40%), Gaps = 72/350 (20%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 + + IG+G F +V+ + DTG A+K + KS + K + +K E ++ Sbjct: 102 EDFHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKDQLAHVKAERDVLAGSDS 161 Query: 69 PNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCK 128 P +V LY +Y+++EF+ GG+L ++ E +R Y + + A+ H Sbjct: 162 PWVVSLYYSFQDAQYLYLIMEFLPGGDLMTMLIRWQLFTEDVTRFYMAECILAIETIHKL 221 Query: 129 GVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVE------------------------ 164 G HR +KP+N+L+D G++K+SDFGLS + + Sbjct: 222 GFIHRAIKPDNILIDIRGHIKLSDFGLSTGFHKTHDSNYYKKLLQQDEATNGISKPGTYN 281 Query: 165 --------------------------LLRTTCGTPNYVA------PEVLSGQGY----DG 188 ++T + +A P+ ++ + + G Sbjct: 282 ANTTDTANKRQTMVVDSISLTMSNRQQIQTWRKSRRLMAYSTVGTPDYIAPEIFLYQGYG 341 Query: 189 SAADIWSCGVILFVILAGYLPFSETDLPGLYRKINA----AEFSCPPWFSAEVKFLIHRI 244 D WS G I++ L G+ PF YRKI +F S E + LI R+ Sbjct: 342 QECDWWSLGAIMYECLIGWPPFCSETPQETYRKIMNFEQTLQFPDDIHISYEAEDLIRRL 401 Query: 245 LDPNPKTRI----QIQGIKKDPWFR-LNYVPIRAREEEEVNLDDIRAVFD 289 L + R+ IK P+FR +++ IR + E + + ++ D Sbjct: 402 LT-HADQRLGRHGGADEIKSHPFFRGVDWNTIR--QVEAPYIPKLSSITD 448 >4UY9-A nrPDB Length = 323 Score = 244 bits (623), Expect = 5e-65, Method: Composition-based stats. Identities = 73/312 (23%), Positives = 133/312 (42%), Gaps = 30/312 (9%) Query: 8 VGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILK-NRMVDQIKREISIMKIV 66 + + IG G F KV A GD VA+K ++ ++ +++E + ++ Sbjct: 8 FAELTLEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKLFAML 65 Query: 67 RHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCH 126 +HPNI+ L V + +V+EF GG L +R++ R+ + Q+ + + H Sbjct: 66 KHPNIIALRGVCLKEPNLCLVMEFARGGPL-NRVLSGKRIPPDILVNWAVQIARGMNYLH 124 Query: 127 CKG---VYHRDLKPENLLL--------DTNGNLKVSDFGLSALPQEGVELLRTTCGTPNY 175 + + HRDLK N+L+ +N LK++DFGL+ ++ + GT + Sbjct: 125 DEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKM--SAAGTYAW 182 Query: 176 VAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKI--NAAEFSCPPWF 233 +APEV+ + +D+WS GV+L+ +L G +PF D + + N P Sbjct: 183 MAPEVIRASMF-SKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTC 241 Query: 234 SAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEVNLDDIRAVFDGIEG 293 L+ +P+P +R I EE + + F ++ Sbjct: 242 PEPFAKLMEDCWNPDPHSRPSFTNILDQ----------LTTIEESGFFEMPKDSFHCLQD 291 Query: 294 SYVAENVERNDE 305 ++ E E D+ Sbjct: 292 NWKHEIQEMFDQ 303 >2J0K-A nrPDB Length = 656 Score = 244 bits (623), Expect = 6e-65, Method: Composition-based stats. Identities = 71/258 (27%), Positives = 120/258 (46%), Gaps = 11/258 (4%) Query: 9 GKYEVGRTIGEGTFAKVKFARNT---DTGDNVAIKIMAKSTILKNRMVDQIKREISIMKI 65 + E+GR IGEG F V + VAIK T + + ++ +E M+ Sbjct: 390 ERIELGRCIGEGQFGDVHQGIYMSPENPAMAVAIKTCKNCT--SDSVREKFLQEALTMRQ 447 Query: 66 VRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRI-VHKGRLEESESRKYFQQLVDAVAH 124 HP+IV+L V+ + + ++I++E T GEL + V K L+ + Y QL A+A+ Sbjct: 448 FDHPHIVKLIGVI-TENPVWIIMELCTLGELRSFLQVRKFSLDLASLILYAYQLSTALAY 506 Query: 125 CHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTP-NYVAPEVLSG 183 K HRD+ N+L+ +K+ DFGLS ++ + P ++APE ++ Sbjct: 507 LESKRFVHRDIAARNVLVSATDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINF 566 Query: 184 QGYDGSAADIWSCGVILFVIL-AGYLPFSETDLPGLYRKINAAE-FSCPPWFSAEVKFLI 241 + + SA+D+W GV ++ IL G PF + +I E PP + L+ Sbjct: 567 RRF-TSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLM 625 Query: 242 HRILDPNPKTRIQIQGIK 259 + +P R + +K Sbjct: 626 TKCWAYDPSRRPRFTELK 643 >5TUR-A nrPDB Length = 404 Score = 244 bits (623), Expect = 7e-65, Method: Composition-based stats. Identities = 87/291 (29%), Positives = 138/291 (47%), Gaps = 18/291 (6%) Query: 2 TKKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVD---QIKR 58 +K +Y+VG +G G F V VAIK + K I + ++ Sbjct: 120 KEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPM 179 Query: 59 EISIMKIVRHPN--IVRLYEVLASPSKIYIVLEFVTG-GELFDRIVHKGRLEESESRKYF 115 E+ ++K V ++RL + P ++LE +LFD I +G L+E +R +F Sbjct: 180 EVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFF 239 Query: 116 QQLVDAVAHCHCKGVYHRDLKPENLLLDTN-GNLKVSDFGLSALPQEGVELLRTTCGTPN 174 Q+++AV HCH GV HRD+K EN+L+D N G LK+ DFG AL ++ V GT Sbjct: 240 WQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVY--TDFDGTRV 297 Query: 175 YVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFS 234 Y PE + Y G +A +WS G++L+ ++ G +PF +I + S Sbjct: 298 YSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQRVS 351 Query: 235 AEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEVNLDDIR 285 +E + LI L P R + I+ PW + +P +E E++L + Sbjct: 352 SECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLP---QETAEIHLHSLS 399 >4E93-A nrPDB Length = 377 Score = 244 bits (623), Expect = 7e-65, Method: Composition-based stats. Identities = 69/251 (27%), Positives = 99/251 (39%), Gaps = 8/251 (3%) Query: 13 VGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIV 72 +G IG G F +V R VA+K L + + +E I+K HPNIV Sbjct: 118 LGEQIGRGNFGEVFSGRLRADNTLVAVKSCR--ETLPPDLKAKFLQEARILKQYSHPNIV 175 Query: 73 RLYEVLASPSKIYIVLEFVTGGELFDRIVHKG-RLEESESRKYFQQLVDAVAHCHCKGVY 131 RL V IYIV+E V GG+ + +G RL + + + K Sbjct: 176 RLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCI 235 Query: 132 HRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTC--GTPNYVAPEVLSGQGYDGS 189 HRDL N L+ LK+SDFG+S +GV + APE L+ G S Sbjct: 236 HRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNY-GRYSS 294 Query: 190 AADIWSCGVILFVILA-GYLPFSETDLPGLYRKINA-AEFSCPPWFSAEVKFLIHRILDP 247 +D+WS G++L+ + G P+ + CP V L+ + Sbjct: 295 ESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAY 354 Query: 248 NPKTRIQIQGI 258 P R I Sbjct: 355 EPGQRPSFSTI 365 >6F3F-A nrPDB Length = 455 Score = 244 bits (622), Expect = 7e-65, Method: Composition-based stats. Identities = 63/246 (25%), Positives = 107/246 (43%), Gaps = 12/246 (4%) Query: 16 TIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLY 75 +G+G F +V T VAIK + T+ + +E +MK +RH +V+LY Sbjct: 194 KLGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMSP----EAFLQEAQVMKKLRHEKLVQLY 248 Query: 76 EVLASPSKIYIVLEFVTGGELFDRIVHK--GRLEESESRKYFQQLVDAVAHCHCKGVYHR 133 V++ IYIV E++ G L D + + L + Q+ +A+ HR Sbjct: 249 AVVSEE-PIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVERMNYVHR 307 Query: 134 DLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTP-NYVAPEVLSGQGYDGSAAD 192 DL+ N+L+ N KV+DFGL+ L ++ R P + APE G +D Sbjct: 308 DLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALY-GRFTIKSD 366 Query: 193 IWSCGVILFVILA-GYLPFSETDLPGLYRKINAA-EFSCPPWFSAEVKFLIHRILDPNPK 250 +WS G++L + G +P+ + ++ CPP + L+ + P+ Sbjct: 367 VWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPE 426 Query: 251 TRIQIQ 256 R + Sbjct: 427 ERPTFE 432 >4RC3-A nrPDB Length = 289 Score = 244 bits (622), Expect = 9e-65, Method: Composition-based stats. Identities = 88/292 (30%), Positives = 139/292 (47%), Gaps = 18/292 (6%) Query: 1 MTKKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVD---QIK 57 M +K +Y+VG +G G F V VAIK + K I + ++ Sbjct: 4 MKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVP 63 Query: 58 REISIMKIVRHPN--IVRLYEVLASPSKIYIVLEFVTG-GELFDRIVHKGRLEESESRKY 114 E+ ++K V ++RL + P ++LE +LFD I +G L+E +R + Sbjct: 64 MEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSF 123 Query: 115 FQQLVDAVAHCHCKGVYHRDLKPENLLLDTN-GNLKVSDFGLSALPQEGVELLRTTCGTP 173 F Q+++AV HCH GV HRD+K EN+L+D N G LK+ DFG AL ++ V GT Sbjct: 124 FWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVY--TDFDGTR 181 Query: 174 NYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWF 233 Y PE + Y G +A +WS G++L+ ++ G +PF +I + Sbjct: 182 VYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQRV 235 Query: 234 SAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEVNLDDIR 285 S+E + LI L P R + I+ PW + +P +E E++L + Sbjct: 236 SSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLP---QETAEIHLHSLS 284 >6CQF-A nrPDB Length = 297 Score = 244 bits (622), Expect = 9e-65, Method: Composition-based stats. Identities = 68/260 (26%), Positives = 122/260 (46%), Gaps = 10/260 (3%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 Y++ + +G GT+ +V AR+ +GD VA+K++ + + V +++EI I+K RH Sbjct: 16 DHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVK---MEPDDDVSTLQKEILILKTCRH 72 Query: 69 PNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCK 128 NIV + K++I +EF G L D G L E + ++++ +A+ H + Sbjct: 73 ANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSQ 132 Query: 129 GVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEV--LSGQGY 186 HRD+K N+L++ G ++++DFG+SA + GTP ++APEV ++ +G Sbjct: 133 KKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLAFIGTPYWMAPEVAAVALKGG 192 Query: 187 DGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPP-----WFSAEVKFLI 241 DIWS G+ + P + + + + + P +SA I Sbjct: 193 YNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFI 252 Query: 242 HRILDPNPKTRIQIQGIKKD 261 L +PK R + Sbjct: 253 KVTLTKSPKKRPSATKMLSH 272 >3DTC-A nrPDB Length = 271 Score = 243 bits (621), Expect = 1e-64, Method: Composition-based stats. Identities = 66/262 (25%), Positives = 118/262 (45%), Gaps = 20/262 (7%) Query: 12 EVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILK-NRMVDQIKREISIMKIVRHPN 70 + IG G F KV A GD VA+K ++ ++ +++E + +++HPN Sbjct: 10 TLEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPN 67 Query: 71 IVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKG- 129 I+ L V + +V+EF GG L +R++ R+ + Q+ + + H + Sbjct: 68 IIALRGVCLKEPNLCLVMEFARGGPL-NRVLSGKRIPPDILVNWAVQIARGMNYLHDEAI 126 Query: 130 --VYHRDLKPENLLL--------DTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPE 179 + HRDLK N+L+ +N LK++DFGL+ ++ + G ++APE Sbjct: 127 VPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKM--SAAGAYAWMAPE 184 Query: 180 VLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKI--NAAEFSCPPWFSAEV 237 V+ + +D+WS GV+L+ +L G +PF D + + N P Sbjct: 185 VIRASMF-SKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPF 243 Query: 238 KFLIHRILDPNPKTRIQIQGIK 259 L+ +P+P +R I Sbjct: 244 AKLMEDCWNPDPHSRPSFTNIL 265 >6DTL-A nrPDB Length = 364 Score = 243 bits (621), Expect = 1e-64, Method: Composition-based stats. Identities = 78/328 (23%), Positives = 125/328 (38%), Gaps = 38/328 (11%) Query: 16 TIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLY 75 IG+G + V A N++T ++VAIK +A + K + REI +++ + H NIV + Sbjct: 37 PIGKGAYGIVCSAMNSETNESVAIKKIANAFDNK-IDAKRTLREIKLLRHMDHENIVAIR 95 Query: 76 EVLASP-----SKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGV 130 +++ P + +YI E + +L I L E + + Q++ + + H V Sbjct: 96 DIIPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANV 154 Query: 131 YHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSA 190 HRDLKP NLLL+ N +LK+ DFGL+ + E + + T Y APE+L +A Sbjct: 155 LHRDLKPSNLLLNANCDLKICDFGLARVTSES-DFMTEYVVTRWYRAPELLLNSSDYTAA 213 Query: 191 ADIWSCGVILFVILAGYLPFSETDLPGLYR----------------------KINAAEFS 228 D+WS G I ++ F D R + Sbjct: 214 IDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPP 273 Query: 229 CP--------PWFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEVN 280 P P LI ++L +P+ RI + P+ + E Sbjct: 274 YPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISDEPECTIPF 333 Query: 281 LDDIRAVFDGIEGSYVAENVERNDEGPL 308 D E E P Sbjct: 334 NFDFENHALSEEQMKELIYREALAFNPE 361 >2XNP-A nrPDB Length = 279 Score = 243 bits (620), Expect = 1e-64, Method: Composition-based stats. Identities = 80/270 (29%), Positives = 135/270 (50%), Gaps = 14/270 (5%) Query: 5 MRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMK 64 R YEV TIG G++ + + R G + K + ++ + + E+++++ Sbjct: 2 PSRAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEK-QMLVSEVNLLR 60 Query: 65 IVRHPNIVRLYEVL--ASPSKIYIVLEFVTGGELFDRI----VHKGRLEESESRKYFQQL 118 ++HPNIVR Y+ + + + +YIV+E+ GG+L I + L+E + QL Sbjct: 61 ELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQL 120 Query: 119 VDAVAHCHC-----KGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTP 173 A+ CH V HRDLKP N+ LD N+K+ DFGL+ + +T GTP Sbjct: 121 TLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTP 180 Query: 174 NYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEF-SCPPW 232 Y++PE ++ Y+ +DIWS G +L+ + A PF+ L KI +F P Sbjct: 181 YYMSPEQMNRMSYN-EKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYR 239 Query: 233 FSAEVKFLIHRILDPNPKTRIQIQGIKKDP 262 +S E+ +I R+L+ R ++ I ++P Sbjct: 240 YSDELNEIITRMLNLKDYHRPSVEEILENP 269 >4MYG-A nrPDB Length = 372 Score = 242 bits (619), Expect = 2e-64, Method: Composition-based stats. Identities = 71/305 (23%), Positives = 123/305 (40%), Gaps = 44/305 (14%) Query: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYE 76 +G G + V A + +G+ VAIK +++ + RE+ ++K ++H N++ L + Sbjct: 51 VGSGAYGSVCSAIDKRSGEKVAIKKLSR-PFQSEIFAKRAYRELLLLKHMQHENVIGLLD 109 Query: 77 VLASPSKI------YIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGV 130 V S + Y+V+ F+ +L + + E + + Q++ + + H GV Sbjct: 110 VFTPASSLRNFYDFYLVMPFMQT-DLQKIMGME--FSEEKIQYLVYQMLKGLKYIHSAGV 166 Query: 131 YHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSA 190 HRDLKP NL ++ + LK+ DFGL+ + T Y APEV+ + Sbjct: 167 VHRDLKPGNLAVNEDCELKILDFGLAR---HADAEMTGYVVTRWYRAPEVILSWMHYNQT 223 Query: 191 ADIWSCGVILFVILAGYLPFSETDLPGLYRKINAA------EF--------------SCP 230 DIWS G I+ +L G F D +I EF S P Sbjct: 224 VDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLP 283 Query: 231 -----------PWFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEV 279 P S + L+ ++L+ + R+ P+F P E ++ Sbjct: 284 QTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEETEAQQP 343 Query: 280 NLDDI 284 D + Sbjct: 344 FDDSL 348 >2R2P-A nrPDB Length = 295 Score = 242 bits (619), Expect = 2e-64, Method: Composition-based stats. Identities = 68/267 (25%), Positives = 112/267 (41%), Gaps = 12/267 (4%) Query: 3 KKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDN---VAIKIMAKSTILKNRMVDQIKRE 59 K + R IG G F +V R G VAIK + K R E Sbjct: 16 AKEIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQR--RDFLGE 73 Query: 60 ISIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHK-GRLEESESRKYFQQL 118 SIM HPNI+ L V+ + IV E++ G L + G+ + + + Sbjct: 74 ASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGI 133 Query: 119 VDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCG---TPNY 175 + + G HRDL N+L+++N KVSDFGLS + ++ E TT G + Sbjct: 134 SAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRW 193 Query: 176 VAPEVLSGQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAA-EFSCPPWF 233 APE ++ + + SA+D+WS G++++ +++ G P+ E + + + P Sbjct: 194 TAPEAIAFRKF-TSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDC 252 Query: 234 SAEVKFLIHRILDPNPKTRIQIQGIKK 260 A + L+ +R + I Sbjct: 253 PAALYQLMLDCWQKERNSRPKFDEIVN 279 >3BGP-A nrPDB Length = 333 Score = 242 bits (618), Expect = 2e-64, Method: Composition-based stats. Identities = 87/291 (29%), Positives = 138/291 (47%), Gaps = 18/291 (6%) Query: 2 TKKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVD---QIKR 58 +K +Y+VG +G G F V VAIK + K I + ++ Sbjct: 49 KEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPM 108 Query: 59 EISIMKIVRHPN--IVRLYEVLASPSKIYIVLEFVTG-GELFDRIVHKGRLEESESRKYF 115 E+ ++K V ++RL + P ++LE +LFD I +G L+E +R +F Sbjct: 109 EVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFF 168 Query: 116 QQLVDAVAHCHCKGVYHRDLKPENLLLDTN-GNLKVSDFGLSALPQEGVELLRTTCGTPN 174 Q+++AV HCH GV HRD+K EN+L+D N G LK+ DFG AL ++ V GT Sbjct: 169 WQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVY--TDFDGTRV 226 Query: 175 YVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFS 234 Y PE + Y G +A +WS G++L+ ++ G +PF +I + S Sbjct: 227 YSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQRVS 280 Query: 235 AEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEVNLDDIR 285 +E + LI L P R + I+ PW + +P +E E++L + Sbjct: 281 SECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLP---QETAEIHLHSLS 328 >3E7O-A nrPDB Length = 360 Score = 242 bits (618), Expect = 3e-64, Method: Composition-based stats. Identities = 76/321 (23%), Positives = 129/321 (40%), Gaps = 54/321 (16%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 +Y+ + IG G V A +T G NVA+K +++ + RE+ ++K V H Sbjct: 23 RYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSR-PFQNQTHAKRAYRELVLLKCVNHK 81 Query: 70 NIVRLYEVL------ASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVA 123 NI+ L V +Y+V+E + +++H L+ Q++ + Sbjct: 82 NIISLLNVFTPQKTLEEFQDVYLVMELMDAN--LCQVIHME-LDHERMSYLLYQMLCGIK 138 Query: 124 HCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSG 183 H H G+ HRDLKP N+++ ++ LK+ DFGL+ ++ T Y APEV+ G Sbjct: 139 HLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTASTNF-MMTPYVVTRYYRAPEVILG 197 Query: 184 QGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAA------------------ 225 GY DIWS G I+ ++ G + F TD + K+ Sbjct: 198 MGY-KENVDIWSVGCIMGELVKGSVIFQGTDHIDQWNKVIEQLGTPSAEFMAALQPTVRN 256 Query: 226 -------------EFSCPPWF-----------SAEVKFLIHRILDPNPKTRIQIQGIKKD 261 E P W +++ + L+ ++L +P RI + + Sbjct: 257 YVENRPAYPGIAFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRH 316 Query: 262 PWFRLNYVPIRAREEEEVNLD 282 P+ + Y P A D Sbjct: 317 PYITVWYDPAEAEAPPPQIYD 337 >1UA2-A nrPDB Length = 346 Score = 242 bits (617), Expect = 3e-64, Method: Composition-based stats. Identities = 82/309 (26%), Positives = 122/309 (39%), Gaps = 36/309 (11%) Query: 7 RVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMA--KSTILKNRMVDQIKREISIMK 64 R +YE +GEG FA V AR+ +T VAIK + + K+ + REI +++ Sbjct: 8 RAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQ 67 Query: 65 IVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRL--EESESRKYFQQLVDAV 122 + HPNI+ L + S I +V +F+ + I+ L S + Y + + Sbjct: 68 ELSHPNIIGLLDAFGHKSNISLVFDFMETD--LEVIIKDNSLVLTPSHIKAYMLMTLQGL 125 Query: 123 AHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLS 182 + H + HRDLKP NLLLD NG LK++DFGL+ T Y APE+L Sbjct: 126 EYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLF 185 Query: 183 GQGYDGSAADIWSCGVILFVILAGYLPF-SETDLPGLYRKINAA-----------EFSCP 230 G G D+W+ G IL +L +PF +I S P Sbjct: 186 GARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLP 244 Query: 231 PWFS-----------------AEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVPIRA 273 + + ++ LI + NP RI K +F P Sbjct: 245 DYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPG 304 Query: 274 REEEEVNLD 282 + N Sbjct: 305 CQLPRPNCP 313 >1U5R-A nrPDB Length = 348 Score = 242 bits (617), Expect = 3e-64, Method: Composition-based stats. Identities = 69/283 (24%), Positives = 119/283 (42%), Gaps = 12/283 (4%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 + R IG G+F V FAR+ + VAIK M+ S N I +E+ ++ +RHPN Sbjct: 56 FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPN 115 Query: 71 IVRLYEVLASPSKIYIVLEFVTG--GELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCK 128 ++ ++V+E+ G +L + VHK L+E E + +A+ H Sbjct: 116 TIQYRGCYLREHTAWLVMEYCLGSASDLLE--VHKKPLQEVEIAAVTHGALQGLAYLHSH 173 Query: 129 GVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVL--SGQGY 186 + HRD+K N+LL G +K+ DFG +++ + GTP ++APEV+ +G Sbjct: 174 NMIHRDVKAGNILLSEPGLVKLGDFGSASIMAP----ANSFVGTPYWMAPEVILAMDEGQ 229 Query: 187 DGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFS--CPPWFSAEVKFLIHRI 244 D+WS G+ + P + I E +S + + Sbjct: 230 YDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPALQSGHWSEYFRNFVDSC 289 Query: 245 LDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEVNLDDIRAV 287 L P+ R + + K + P + + D +R + Sbjct: 290 LQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKDAVREL 332 >2Y6O-A nrPDB Length = 291 Score = 242 bits (617), Expect = 3e-64, Method: Composition-based stats. Identities = 62/262 (23%), Positives = 110/262 (41%), Gaps = 12/262 (4%) Query: 8 VGKYEVGRTIGEGTFAKVKFARNTDTGDN---VAIKIMAKSTILKNRMVDQIKREISIMK 64 ++ + IG G F +V R G VAIK + ++ E SIM Sbjct: 13 ASCIKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLK--AGYTDKQRRDFLSEASIMG 70 Query: 65 IVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHK-GRLEESESRKYFQQLVDAVA 123 HPNI+ L V+ + I+ E++ G L + GR + + + + Sbjct: 71 QFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMK 130 Query: 124 HCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCG---TPNYVAPEV 180 + HRDL N+L+++N KVSDFG+S + ++ E TT G + APE Sbjct: 131 YLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEA 190 Query: 181 LSGQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAAEFSCPP-WFSAEVK 238 ++ + + SA+D+WS G++++ +++ G P+ + + + I PP + Sbjct: 191 IAYRKF-TSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPPMDCPIALH 249 Query: 239 FLIHRILDPNPKTRIQIQGIKK 260 L+ R + I Sbjct: 250 QLMLDCWQKERSDRPKFGQIVN 271 >1JPA-A nrPDB Length = 312 Score = 242 bits (617), Expect = 3e-64, Method: Composition-based stats. Identities = 60/265 (22%), Positives = 110/265 (41%), Gaps = 16/265 (6%) Query: 8 VGKYEVGRTIGEGTFAKVKFARNTDTGDN---VAIKIMAKSTILKNRMVDQIKREISIMK 64 + ++ + IG G F +V G VAIK + K R E SIM Sbjct: 32 ISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQR--RDFLSEASIMG 89 Query: 65 IVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHK-GRLEESESRKYFQQLVDAVA 123 HPN++ L V+ + + I+ EF+ G L + G+ + + + + Sbjct: 90 QFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMK 149 Query: 124 HCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVE--LLRTTCG---TPNYVAP 178 + HRDL N+L+++N KVSDFGLS ++ + G + AP Sbjct: 150 YLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAP 209 Query: 179 EVLSGQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAAEFSCPP--WFSA 235 E + + + SA+D+WS G++++ +++ G P+ + + I ++ PP + Sbjct: 210 EAIQYRKF-TSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQ-DYRLPPPMDCPS 267 Query: 236 EVKFLIHRILDPNPKTRIQIQGIKK 260 + L+ + R + I Sbjct: 268 ALHQLMLDCWQKDRNHRPKFGQIVN 292 >4ZSG-A nrPDB Length = 347 Score = 242 bits (617), Expect = 3e-64, Method: Composition-based stats. Identities = 80/341 (23%), Positives = 128/341 (37%), Gaps = 46/341 (13%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 +YE+ TIG G + V AR TG VAIK + + + + RE+ I+K +H Sbjct: 7 DEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDV-VTNAKRTLRELKILKHFKH 65 Query: 69 PNIVRLYEV------LASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAV 122 NI+ + ++ +Y+VL+ + +L I L R + QL+ + Sbjct: 66 DNIIAIKDILRPTVPYGEFKSVYVVLDLME-SDLHQIIHSSQPLTLEHVRYFLYQLLRGL 124 Query: 123 AHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSA----LPQEGVELLRTTCGTPNYVAP 178 + H V HRDLKP NLL++ N LK+ DFG++ P E + T Y AP Sbjct: 125 KYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAP 184 Query: 179 EVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETD------------------------ 214 E++ A D+WS G I +LA F + Sbjct: 185 ELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVG 244 Query: 215 LPGLYRKINAAEFSCP-------PWFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLN 267 + I + P P + L+ R+L P RI + P+ Sbjct: 245 AERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKY 304 Query: 268 YVPIRAREEEEVN---LDDIRAVFDGIEGSYVAENVERNDE 305 + P + D + I+ + VAE + + Sbjct: 305 HDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFHAR 345 >5SYS-A nrPDB Length = 286 Score = 241 bits (616), Expect = 4e-64, Method: Composition-based stats. Identities = 62/246 (25%), Positives = 108/246 (43%), Gaps = 12/246 (4%) Query: 16 TIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLY 75 +G+G F + T VAIK + T+ + +E +MK +RH +V+LY Sbjct: 25 KLGQGCFGECWMGTWNGT-TRVAIKTLKPGTMSP----EAFLQEAQVMKKLRHEKLVQLY 79 Query: 76 EVLASPSKIYIVLEFVTGGELFDRIVHK--GRLEESESRKYFQQLVDAVAHCHCKGVYHR 133 V++ IYIV E+++ G L D + + L + Q+ +A+ HR Sbjct: 80 AVVSEE-PIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHR 138 Query: 134 DLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTP-NYVAPEVLSGQGYDGSAAD 192 DL+ N+L+ N KV+DFGL+ L ++ R P + APE G +D Sbjct: 139 DLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALY-GRFTIKSD 197 Query: 193 IWSCGVILFVILA-GYLPFSETDLPGLYRKINAA-EFSCPPWFSAEVKFLIHRILDPNPK 250 +WS G++L + G +P+ + ++ CPP + L+ + +P+ Sbjct: 198 VWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKDPE 257 Query: 251 TRIQIQ 256 R + Sbjct: 258 ERPTFE 263 >4QNY-A nrPDB Length = 354 Score = 241 bits (616), Expect = 4e-64, Method: Composition-based stats. Identities = 79/328 (24%), Positives = 130/328 (39%), Gaps = 48/328 (14%) Query: 9 GKYEVGRTIGEGTFAKVKFARN-TDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR 67 +Y + R IG G++ V AR+ VA+K + K + + +I REI ++ Sbjct: 20 DRYLLERIIGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEEVILAKRILREIKLLAHFN 79 Query: 68 HPNIVRLYEVLASPS-----KIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAV 122 NI+ L +L YIV++ + +L + L E+ + + Q + A+ Sbjct: 80 DDNIIGLRNILTPEDPENFDHFYIVMDIMET-DLKQVLRSGQELTEAHIQFFIYQALRAL 138 Query: 123 AHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLS 182 H GV HRD+ P N+L++TN +LK+ DFGL+ + E + Y APE++ Sbjct: 139 HIIHSAGVIHRDITPANILVNTNCDLKICDFGLAKEENDQGEYMTDYVTMRWYRAPELVM 198 Query: 183 GQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCP------------ 230 + D+W G IL +L F D KI + Sbjct: 199 EDKDYSAQIDVWGIGCILGELLGSRPLFQGKDRVNQLDKIVDVIGTPSEEDINSVGSSAA 258 Query: 231 -------------------PWFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFR------ 265 P S E L+ +L NPK RI + + P+ Sbjct: 259 QKYLKKKSHRPQADWRQRYPTASPEALDLLRHMLVFNPKRRITVLQAMRHPFLEQLHDDA 318 Query: 266 ---LNYVPIRAREEEEVNLDDI-RAVFD 289 L+Y R E E+ + D+ RA+++ Sbjct: 319 DDNLSYALFRFDENEQKTIVDVKRAIYE 346 >5A46-A nrPDB Length = 386 Score = 240 bits (614), Expect = 7e-64, Method: Composition-based stats. Identities = 59/281 (20%), Positives = 117/281 (41%), Gaps = 31/281 (11%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGD-------NVAIKIMAKSTILKNRMVDQIKREIS 61 + +G+ +GEG F +V A VA+K++ K+ + + E+ Sbjct: 40 DRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKD--LSDLISEME 97 Query: 62 IMKIV-RHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHK----------------G 104 +MK++ +H NI+ L +Y+++E+ + G L + + + Sbjct: 98 MMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEE 157 Query: 105 RLEESESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVE 164 +L + Q+ + + K HRDL N+L+ + +K++DFGL+ Sbjct: 158 QLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDY 217 Query: 165 LLRTTCG--TPNYVAPEVLSGQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRK 221 +TT G ++APE L + Y +D+WS GV+L+ I G P+ + L++ Sbjct: 218 YKKTTNGRLPVKWMAPEALFDRIY-THQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKL 276 Query: 222 INAA-EFSCPPWFSAEVKFLIHRILDPNPKTRIQIQGIKKD 261 + P + E+ ++ P R + + +D Sbjct: 277 LKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVED 317 >5Z33-A nrPDB Length = 425 Score = 240 bits (614), Expect = 7e-64, Method: Composition-based stats. Identities = 77/321 (23%), Positives = 130/321 (40%), Gaps = 42/321 (13%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR- 67 +Y V + +G+G + V A N T + VAIK + K + + REI +++ R Sbjct: 31 ERYTVTKELGQGAYGIVCAAVNNQTSEGVAIKKVTN-VFSKKILAKRALREIKLLQHFRG 89 Query: 68 HPNIVRLYEVLASP----SKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVA 123 H NI LY++ ++ Y+ E + +L I L ++ + + Q++ + Sbjct: 90 HRNITCLYDMDIPRPDNFNETYLYEELMEC-DLAAIIRSGQPLTDAHFQSFIYQILCGLK 148 Query: 124 HCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSA----LPQEGVELLRTTCGTPNYVAPE 179 + H V HRDLKP NLL++ + LK+ DFGL+ P+E + T Y APE Sbjct: 149 YIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSVDPEENAGYMTEYVATRWYRAPE 208 Query: 180 VLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKIN---------------- 223 ++ A D+WS G IL +L G F D +I Sbjct: 209 IMLSFQSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQILHILGTPNEETLSRIGS 268 Query: 224 ------------AAEFSCP---PWFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLNY 268 A+ P P + + L+ R+L +P +RI ++ + P+ + + Sbjct: 269 PRAQEYVRNLPFMAKKPFPTLFPNANPDALDLLDRMLAFDPSSRISVEQALEHPYLHIWH 328 Query: 269 VPIRAREEEEVNLDDIRAVFD 289 + D V D Sbjct: 329 DASDEPDCPTTFNFDFEVVED 349 >2GCD-A nrPDB Length = 309 Score = 240 bits (614), Expect = 7e-64, Method: Composition-based stats. Identities = 69/283 (24%), Positives = 119/283 (42%), Gaps = 12/283 (4%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 + R IG G+F V FAR+ + VAIK M+ S N I +E+ ++ +RHPN Sbjct: 17 FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPN 76 Query: 71 IVRLYEVLASPSKIYIVLEFVTG--GELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCK 128 ++ ++V+E+ G +L + VHK L+E E + +A+ H Sbjct: 77 TIQYRGCYLREHTAWLVMEYCLGSASDLLE--VHKKPLQEVEIAAVTHGALQGLAYLHSH 134 Query: 129 GVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVL--SGQGY 186 + HRD+K N+LL G +K+ DFG +++ + GTP ++APEV+ +G Sbjct: 135 NMIHRDVKAGNILLSEPGLVKLGDFGSASIMAP----ANSFVGTPYWMAPEVILAMDEGQ 190 Query: 187 DGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFS--CPPWFSAEVKFLIHRI 244 D+WS G+ + P + I E +S + + Sbjct: 191 YDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPALQSGHWSEYFRNFVDSC 250 Query: 245 LDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEVNLDDIRAV 287 L P+ R + + K + P + + D +R + Sbjct: 251 LQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKDAVREL 293 >3TT0-A nrPDB Length = 382 Score = 240 bits (613), Expect = 9e-64, Method: Composition-based stats. Identities = 59/281 (20%), Positives = 117/281 (41%), Gaps = 31/281 (11%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGD-------NVAIKIMAKSTILKNRMVDQIKREIS 61 + +G+ +GEG F +V A VA+K++ K+ + + E+ Sbjct: 69 DRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKD--LSDLISEME 126 Query: 62 IMKIV-RHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHK----------------G 104 +MK++ +H NI+ L +Y+++E+ + G L + + + Sbjct: 127 MMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYSYNPSHNPEE 186 Query: 105 RLEESESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVE 164 +L + Q+ + + K HRDL N+L+ + +K++DFGL+ Sbjct: 187 QLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDY 246 Query: 165 LLRTTCG--TPNYVAPEVLSGQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRK 221 +TT G ++APE L + Y +D+WS GV+L+ I G P+ + L++ Sbjct: 247 YKKTTNGRLPVKWMAPEALFDRIY-THQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKL 305 Query: 222 INAA-EFSCPPWFSAEVKFLIHRILDPNPKTRIQIQGIKKD 261 + P + E+ ++ P R + + +D Sbjct: 306 LKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVED 346 >3OZ6-A nrPDB Length = 388 Score = 240 bits (613), Expect = 1e-63, Method: Composition-based stats. Identities = 81/374 (21%), Positives = 134/374 (35%), Gaps = 84/374 (22%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR-H 68 KYE+ + +G+G + V + + TG+ VA+K + + + REI I+ + H Sbjct: 10 KYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIF-DAFQNSTDAQRTFREIMILTELSGH 68 Query: 69 PNIVRLYEVLASPSK--IYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCH 126 NIV L VL + + +Y+V +++ ++ LE + QL+ + + H Sbjct: 69 ENIVNLLNVLRADNDRDVYLVFDYMETD--LHAVIRANILEPVHKQYVVYQLIKVIKYLH 126 Query: 127 CKGVYHRDLKPENLLLDTNGNLKVSDFGLSAL---------------------PQEGVEL 165 G+ HRD+KP N+LL+ ++KV+DFGLS + + Sbjct: 127 SGGLLHRDMKPSNILLNAECHVKVADFGLSRSFVNIRRVTNNIPLSINENTENFDDDQPI 186 Query: 166 LRTTCGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAA 225 L T Y APE+L G D+WS G IL IL G F + +I Sbjct: 187 LTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGKPIFPGSSTMNQLERII-G 245 Query: 226 EFSCPPW------------------------------------------------FSAEV 237 P + E Sbjct: 246 VIDFPSNEDVESIQSPFAKTMIESLKEKVEIRQSNKRDIFTKWKNLLLKINPKADCNEEA 305 Query: 238 KFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEVNL------DDIRAVFDGI 291 L+ ++L NP RI K P+ + + P E ++ D+++ D Sbjct: 306 LDLLDKLLQFNPNKRISANDALKHPFVSIFHNP--NEEPNCDHIITIPINDNVKHSIDDY 363 Query: 292 EGSYVAENVERNDE 305 +E R E Sbjct: 364 RNLVYSEISRRKRE 377 >4AT3-A nrPDB Length = 299 Score = 240 bits (613), Expect = 1e-63, Method: Composition-based stats. Identities = 62/282 (21%), Positives = 109/282 (38%), Gaps = 28/282 (9%) Query: 1 MTKKMRRVGKYEVG--RTIGEGTFAKVKFARN-----TDTGDNVAIKIMAKSTILKNRMV 53 M ++ + ++ + R +GEG F KV A VA+K + + Sbjct: 3 MDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLK---DASDNAR 59 Query: 54 DQIKREISIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGR-------- 105 RE ++ ++H +IV+ Y V + +V E++ G+L + G Sbjct: 60 KDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEG 119 Query: 106 -----LEESESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQ 160 L +S+ QQ+ + + + HRDL N L+ N +K+ DFG+S Sbjct: 120 NPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVY 179 Query: 161 EGVELL--RTTCGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPG 217 T ++ PE + + + + +D+WS GV+L+ I G P+ + Sbjct: 180 STDYYRVGGHTMLPIRWMPPESIMYRKF-TTESDVWSLGVVLWEIFTYGKQPWYQLSNNE 238 Query: 218 LYRKINAAE-FSCPPWFSAEVKFLIHRILDPNPKTRIQIQGI 258 + I P EV L+ P R I+GI Sbjct: 239 VIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGI 280 >4QTB-A nrPDB Length = 380 Score = 240 bits (613), Expect = 1e-63, Method: Composition-based stats. Identities = 73/311 (23%), Positives = 119/311 (38%), Gaps = 45/311 (14%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 +Y + IGEG + V A + VAIK ++ + REI I+ RH Sbjct: 42 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS--PFEHQTYCQRTLREIQILLRFRHE 99 Query: 70 NIVRLYEVL-----ASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAH 124 N++ + ++L + +YIV + + +L+ + + +L + Q++ + + Sbjct: 100 NVIGIRDILRASTLEAMRDVYIVQDLMET-DLYKLLKSQ-QLSNDHICYFLYQILRGLKY 157 Query: 125 CHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSAL---PQEGVELLRTTCGTPNYVAPEVL 181 H V HRDLKP NLL++T +LK+ DFGL+ + + L T Y APE++ Sbjct: 158 IHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIM 217 Query: 182 SGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCP----------- 230 + DIWS G IL +L+ F I P Sbjct: 218 LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHIL-GILGSPSQEDLNCIINM 276 Query: 231 ---------------------PWFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYV 269 P ++ L+ R+L NP RI ++ P+ Y Sbjct: 277 KARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYD 336 Query: 270 PIRAREEEEVN 280 P EE Sbjct: 337 PTDEPVAEEPF 347 >3HKO-A nrPDB Length = 345 Score = 240 bits (612), Expect = 1e-63, Method: Composition-based stats. Identities = 90/308 (29%), Positives = 135/308 (43%), Gaps = 53/308 (17%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILK--NRMVDQIKREISIMKIVR 67 KY + IG+G++ V+ A T AIKIM K+ I + + V++IK E+ +MK + Sbjct: 27 KYHLKGAIGQGSYGVVRVAIENQTRAIRAIKIMNKNKIRQINPKDVERIKTEVRLMKKLH 86 Query: 68 HPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIV-------------------------- 101 HPNI RLYEV I +V+E GG L D++ Sbjct: 87 HPNIARLYEVYEDEQYICLVMELCHGGHLLDKLNVFIDDSTGKCAMDVVKTQICPCPECN 146 Query: 102 ----------HKGRLE----ESESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNG- 146 + L+ E +Q+ A+ + H +G+ HRD+KPEN L TN Sbjct: 147 EEAINGSIHGFRESLDFVQREKLISNIMRQIFSALHYLHNQGICHRDIKPENFLFSTNKS 206 Query: 147 -NLKVSDFGLS----ALPQEGVELLRTTCGTPNYVAPEVLSGQGY-DGSAADIWSCGVIL 200 +K+ DFGLS L + T GTP +VAPEVL+ G D WS GV+L Sbjct: 207 FEIKLVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEVLNTTNESYGPKCDAWSAGVLL 266 Query: 201 FVILAGYLPFSETDLPGLYRKINAAE--FSCPPW--FSAEVKFLIHRILDPNPKTRIQIQ 256 ++L G +PF + ++ + F P + S + L+ +L+ N R Sbjct: 267 HLLLMGAVPFPGVNDADTISQVLNKKLCFENPNYNVLSPLARDLLSNLLNRNVDERFDAM 326 Query: 257 GIKKDPWF 264 + PW Sbjct: 327 RALQHPWI 334 >5VO2-A nrPDB Length = 300 Score = 239 bits (610), Expect = 2e-63, Method: Composition-based stats. Identities = 63/283 (22%), Positives = 116/283 (40%), Gaps = 27/283 (9%) Query: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYE 76 +G G V R G+ VA+K + I ++ ++HPNI+ Sbjct: 20 VGSGAQGAVFLGRFH--GEEVAVKKVRDLKETD----------IKHLRKLKHPNIITFKG 67 Query: 77 VLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDLK 136 V I++EF G+L++ + + S + + + + H + HRDLK Sbjct: 68 VCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLK 127 Query: 137 PENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSAADIWSC 196 N+L+ + +K+SDFG S + + + GT ++APEV+ + DIWS Sbjct: 128 SPNMLITYDDVVKISDFGTSKELSDKSTKM-SFAGTVAWMAPEVIRNEPV-SEKVDIWSF 185 Query: 197 GVILFVILAGYLPFSETDLPGLYRKI--NAAEFSCPPWFSAEVKFLIHRILDPNPKTRIQ 254 GV+L+ +L G +P+ + D + + N+ P K L+ + + P+ R Sbjct: 186 GVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPS 245 Query: 255 IQGIKKD-----------PWFRLNYVPIRAREEEEVNLDDIRA 286 + I P REE +++ + I++ Sbjct: 246 FRQILLHLDIASADVLSTPQETYFKSQAEWREEVKLHFEKIKS 288 >3GQL-A nrPDB Length = 326 Score = 239 bits (609), Expect = 2e-63, Method: Composition-based stats. Identities = 59/281 (20%), Positives = 117/281 (41%), Gaps = 31/281 (11%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGD-------NVAIKIMAKSTILKNRMVDQIKREIS 61 + +G+ +GEG F +V A VA+K++ K+ + + E+ Sbjct: 28 DRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKD--LSDLISEME 85 Query: 62 IMKIV-RHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHK----------------G 104 +MK++ +H NI+ L +Y+++E+ + G L + + + Sbjct: 86 MMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEE 145 Query: 105 RLEESESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVE 164 +L + Q+ + + K HRDL N+L+ + +K++DFGL+ Sbjct: 146 QLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDY 205 Query: 165 LLRTTCG--TPNYVAPEVLSGQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRK 221 +TT G ++APE L + Y +D+WS GV+L+ I G P+ + L++ Sbjct: 206 YKKTTNGRLPVKWMAPEALFDRIY-THQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKL 264 Query: 222 INAA-EFSCPPWFSAEVKFLIHRILDPNPKTRIQIQGIKKD 261 + P + E+ ++ P R + + +D Sbjct: 265 LKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVED 305 >4BGQ-A nrPDB Length = 304 Score = 239 bits (609), Expect = 3e-63, Method: Composition-based stats. Identities = 73/291 (25%), Positives = 116/291 (39%), Gaps = 35/291 (12%) Query: 8 VGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR 67 + K+E+ +GEG + V R+ +T + VAIK K + + + RE+ +++ ++ Sbjct: 11 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKF-KDSEENEEVKETTLRELKMLRTLK 69 Query: 68 HPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHC 127 NIV L E K+Y+V E+V L + + + Y QL+ A+ CH Sbjct: 70 QENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHK 129 Query: 128 KGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVEL-LRTTCGTPNYVAPEVLSGQGY 186 + HRD+KPENLL+ N LK+ DFG + EG T Y +PE+L G Y Sbjct: 130 NDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYDEEVATRWYRSPELLLGAPY 189 Query: 187 DGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPW-------------- 232 G + D+WS G IL + G F I P Sbjct: 190 -GKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGL 248 Query: 233 ------------------FSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFR 265 ++ + L+ +L +P R + P F+ Sbjct: 249 RFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQ 299 >4U41-A nrPDB Length = 332 Score = 239 bits (609), Expect = 3e-63, Method: Composition-based stats. Identities = 80/314 (25%), Positives = 132/314 (42%), Gaps = 28/314 (8%) Query: 8 VGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKI-V 66 G +E+ +G GT+ +V R+ TG AIK+M + ++IK EI+++K Sbjct: 23 AGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMD----VTEDEEEEIKLEINMLKKYS 78 Query: 67 RHPNIVRLYEVLA------SPSKIYIVLEFVTGGELFDRIVHK--GRLEESESRKYFQQL 118 H NI Y ++++V+EF G + D + + L+E +++ Sbjct: 79 HHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREI 138 Query: 119 VDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAP 178 + +AH H V HRD+K +N+LL N +K+ DFG+SA V T GTP ++AP Sbjct: 139 LRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 198 Query: 179 EVLSGQGY----DGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWF- 233 EV++ +D+WSCG+ + G P + I + PP Sbjct: 199 EVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLI---PRNPPPRLK 255 Query: 234 ----SAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEVNLD---DIRA 286 S + I L N R + + K P+ R + R + + ++D R Sbjct: 256 SKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRG 315 Query: 287 VFDGIEGSYVAENV 300 D E Y Sbjct: 316 EKDETEYEYSGSEE 329 >2EHB-D nrPDB Length = 143 Score = 239 bits (609), Expect = 3e-63, Method: Composition-based stats. Identities = 143/143 (100%), Positives = 143/143 (100%) Query: 304 DEGPLMMNAFEMITLSQGLNLSALFDRRQDFVKRQTRFVSRREPSEIIANIEAVANSMGF 363 DEGPLMMNAFEMITLSQGLNLSALFDRRQDFVKRQTRFVSRREPSEIIANIEAVANSMGF Sbjct: 1 DEGPLMMNAFEMITLSQGLNLSALFDRRQDFVKRQTRFVSRREPSEIIANIEAVANSMGF 60 Query: 364 KSHTRNFKTRLEGLSSIKAGQLAVVIEIYEVAPSLFMVDVRKAAGETLEYHKFYKKLCSK 423 KSHTRNFKTRLEGLSSIKAGQLAVVIEIYEVAPSLFMVDVRKAAGETLEYHKFYKKLCSK Sbjct: 61 KSHTRNFKTRLEGLSSIKAGQLAVVIEIYEVAPSLFMVDVRKAAGETLEYHKFYKKLCSK 120 Query: 424 LENIIWRATEGIPKSEILRTITF 446 LENIIWRATEGIPKSEILRTITF Sbjct: 121 LENIIWRATEGIPKSEILRTITF 143 >4X7Q-B nrPDB Length = 312 Score = 239 bits (609), Expect = 3e-63, Method: Composition-based stats. Identities = 86/265 (32%), Positives = 131/265 (49%), Gaps = 17/265 (6%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKR---EISIMKIV 66 +Y +G +G+G F V VAIK++ ++ +L + E++++ V Sbjct: 32 EYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKV 91 Query: 67 R----HPNIVRLYEVLASPSKIYIVLE-FVTGGELFDRIVHKGRLEESESRKYFQQLVDA 121 HP ++RL + + +VLE + +LFD I KG L E SR +F Q+V A Sbjct: 92 GAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAA 151 Query: 122 VAHCHCKGVYHRDLKPENLLLD-TNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEV 180 + HCH +GV HRD+K EN+L+D G K+ DFG AL + E GT Y PE Sbjct: 152 IQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHD--EPYTDFDGTRVYSPPEW 209 Query: 181 LSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFL 240 +S Y A +WS G++L+ ++ G +PF ++I AE P S + L Sbjct: 210 ISRHQYHALPATVWSLGILLYDMVCGDIPFERD------QEILEAELHFPAHVSPDCCAL 263 Query: 241 IHRILDPNPKTRIQIQGIKKDPWFR 265 I R L P P +R ++ I DPW + Sbjct: 264 IRRCLAPKPSSRPSLEEILLDPWMQ 288 >3KUL-B nrPDB Length = 325 Score = 239 bits (609), Expect = 3e-63, Method: Composition-based stats. Identities = 65/261 (24%), Positives = 107/261 (40%), Gaps = 12/261 (4%) Query: 7 RVGKYEVGRTIGEGTFAKVKFARNTDTGDN---VAIKIMAKSTILKNRMVDQIKREISIM 63 + + + IG G +V + R G VAIK + R E SIM Sbjct: 47 EASRIHIEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKALK--AGYTERQRRDFLSEASIM 104 Query: 64 KIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIV-HKGRLEESESRKYFQQLVDAV 122 HPNI+RL V+ IV E++ G L + H G+ + + + + Sbjct: 105 GQFDHPNIIRLEGVVTRGRLAMIVTEYMENGSLDTFLRTHDGQFTIMQLVGMLRGVGAGM 164 Query: 123 AHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCG---TPNYVAPE 179 + G HRDL N+L+D+N KVSDFGLS + ++ + TT G + APE Sbjct: 165 RYLSDLGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTAPE 224 Query: 180 VLSGQGYDGSAADIWSCGVILFV-ILAGYLPFSETDLPGLYRKINAA-EFSCPPWFSAEV 237 ++ + + SA+D+WS GV+++ + G P+ + + P + Sbjct: 225 AIAFRTF-SSASDVWSFGVVMWEVLAYGERPYWNMTNRDVISSVEEGYRLPAPMGCPHAL 283 Query: 238 KFLIHRILDPNPKTRIQIQGI 258 L+ + R + I Sbjct: 284 HQLMLDCWHKDRAQRPRFSQI 304 >5NGU-A nrPDB Length = 381 Score = 239 bits (609), Expect = 3e-63, Method: Composition-based stats. Identities = 75/313 (23%), Positives = 121/313 (38%), Gaps = 43/313 (13%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 +Y IGEG + V A + VAIK ++ + REI I+ RH Sbjct: 43 RYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKIS--PFEHQTYCQRTLREIKILLRFRHE 100 Query: 70 NIVRLYEVLASPS-----KIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAH 124 NI+ + +++ +P+ +YIV + + +L+ ++ L + Q++ + + Sbjct: 101 NIIGINDIIRAPTIEQMKDVYIVQDLMET-DLYK-LLKTQHLSNDHICYFLYQILRGLKY 158 Query: 125 CHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVE---LLRTTCGTPNYVAPEVL 181 H V HRDLKP NLLL+T +LK+ DFGL+ + + L T Y APE++ Sbjct: 159 IHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIM 218 Query: 182 SGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKI------------------- 222 + DIWS G IL +L+ F I Sbjct: 219 LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLK 278 Query: 223 -NAAEFSCP-----------PWFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVP 270 S P P ++ L+ ++L NP RI+++ P+ Y P Sbjct: 279 ARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDP 338 Query: 271 IRAREEEEVNLDD 283 E D Sbjct: 339 SDEPIAEAPFKFD 351 >5AWM-A nrPDB Length = 394 Score = 238 bits (608), Expect = 4e-63, Method: Composition-based stats. Identities = 77/321 (23%), Positives = 122/321 (38%), Gaps = 57/321 (17%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 +Y R IG G V A +T T NVAIK +++ + RE +MK+V H Sbjct: 44 SRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSR-PFQNVTHAKRAYREFKLMKLVNH 102 Query: 69 PNIVRLYEVL------ASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAV 122 NI+ L +Y+V+E + L I L+ Q++ + Sbjct: 103 KNIIGLLNAFTPQRNLEEFQDVYLVMELMDA-NLCQVIQMD--LDHDRMSYLLYQMLCGI 159 Query: 123 AHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLS 182 H H G+ HRDLKP N+++ + LK+ DFGL+ ++ T Y APEV+ Sbjct: 160 KHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTF-MMTPYVVTRYYRAPEVIL 218 Query: 183 GQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSA------- 235 G GY DIWS G I+ ++ G + F TD + KI + P F Sbjct: 219 GMGY-TENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVR 277 Query: 236 ------------------------------------EVKFLIHRILDPNPKTRIQIQGIK 259 + + L+ ++L +P+ RI + Sbjct: 278 NYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEAL 337 Query: 260 KDPWFRL--NYVPIRAREEEE 278 K + + + + A E Sbjct: 338 KHEYINVWYDAEEVDAPAPEP 358 >3GC9-A nrPDB Length = 370 Score = 238 bits (608), Expect = 4e-63, Method: Composition-based stats. Identities = 64/311 (20%), Positives = 117/311 (37%), Gaps = 43/311 (13%) Query: 5 MRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMK 64 + + R +G G + V A + VA+K +++ + RE+ ++K Sbjct: 24 WEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSR-PFQSLIHARRTYRELRLLK 82 Query: 65 IVRHPNIVRLYEVL------ASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQL 118 ++H N++ L +V S++Y+V + G + IV L + + QL Sbjct: 83 HLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKSQALSDEHVQFLVYQL 140 Query: 119 VDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAP 178 + + + H G+ HRDLKP N+ ++ + L++ DFGL+ E + T Y AP Sbjct: 141 LRGLKYIHSAGIIHRDLKPSNVAVNEDSELRILDFGLARQADEE---MTGYVATRWYRAP 197 Query: 179 EVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWF----- 233 E++ + DIWS G I+ +L G F +D ++I + P Sbjct: 198 EIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKIS 257 Query: 234 --------------------------SAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLN 267 + L+ R+L + R+ +F Sbjct: 258 SEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQY 317 Query: 268 YVPIRAREEEE 278 + P E E Sbjct: 318 HDPEDEPEAEP 328 >3V5Q-A nrPDB Length = 297 Score = 238 bits (607), Expect = 4e-63, Method: Composition-based stats. Identities = 61/271 (22%), Positives = 105/271 (38%), Gaps = 29/271 (10%) Query: 13 VGRTIGEGTFAKVKFARN-----TDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR 67 + R +GEG F KV A T VA+K + T+ +RE ++ ++ Sbjct: 19 LKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLA---ARKDFQREAELLTNLQ 75 Query: 68 HPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGR----------------LEESES 111 H +IV+ Y V + +V E++ G+L + G L S+ Sbjct: 76 HEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQM 135 Query: 112 RKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELL--RTT 169 Q+ + + + HRDL N L+ N +K+ DFG+S T Sbjct: 136 LHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHT 195 Query: 170 CGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAAE-F 227 ++ PE + + + + +D+WS GVIL+ I G P+ + + I Sbjct: 196 MLPIRWMPPESIMYRKF-TTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVL 254 Query: 228 SCPPWFSAEVKFLIHRILDPNPKTRIQIQGI 258 P EV ++ P+ R+ I+ I Sbjct: 255 ERPRVCPKEVYDVMLGCWQREPQQRLNIKEI 285 >6GQK-A nrPDB Length = 328 Score = 238 bits (607), Expect = 4e-63, Method: Composition-based stats. Identities = 62/280 (22%), Positives = 111/280 (39%), Gaps = 30/280 (10%) Query: 9 GKYEVGRTIGEGTFAKVKFAR-----NTDTGDNVAIKIMAKSTILKNRMVDQIKREISIM 63 + G+T+G G F KV A +D VA+K++ S R + + E+ ++ Sbjct: 41 NRLSFGKTLGAGAFGKVVEATAQGLIKSDAAMTVAVKMLKPSAHSTER--EALMSELKVL 98 Query: 64 KIV-RHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGR----------------L 106 + H NIV L ++ E+ G+L + + K L Sbjct: 99 SYLGNHENIVNLLGACTHGGPTLVITEYCCYGDLLNFLRRKRDEFVPYKVAPEDLYKDFL 158 Query: 107 EESESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQ-EGVEL 165 + Q+ +A K HRDL N+LL K+ DFGL+ + + + Sbjct: 159 TLEHLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGNITKICDFGLARDIKNDSNYV 218 Query: 166 LRTTCGTP-NYVAPEVLSGQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKIN 223 + P ++APE + Y +D+WS G+ L+ + + G P+ + + K+ Sbjct: 219 DKGNARLPVKWMAPESIFNSVY-TFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMI 277 Query: 224 AAEFSC--PPWFSAEVKFLIHRILDPNPKTRIQIQGIKKD 261 F P + AE+ ++ D +P R + I +D Sbjct: 278 KEGFRMSSPEYAPAEMYDIMKTCWDADPDKRPTFKQIVQD 317 >1JNK-A nrPDB Length = 423 Score = 238 bits (607), Expect = 4e-63, Method: Composition-based stats. Identities = 74/322 (22%), Positives = 123/322 (38%), Gaps = 54/322 (16%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 +Y+ + IG G V A + NVAIK +++ + RE+ +MK V H Sbjct: 63 RYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSR-PFQNQTHAKRAYRELVLMKCVNHK 121 Query: 70 NIVRLYEVL------ASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVA 123 NI+ L V +Y+V+E + L I + L+ Q++ + Sbjct: 122 NIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQME--LDHERMSYLLYQMLCGIK 178 Query: 124 HCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSG 183 H H G+ HRDLKP N+++ ++ LK+ DFGL+ ++ T Y APEV+ G Sbjct: 179 HLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF-MMTPYVVTRYYRAPEVILG 237 Query: 184 QGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRK-INAAEFSCPPWF--------- 233 GY DIWS G I+ ++ + F D + K I CP + Sbjct: 238 MGY-KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRN 296 Query: 234 --------------------------------SAEVKFLIHRILDPNPKTRIQIQGIKKD 261 +++ + L+ ++L +P RI + + Sbjct: 297 YVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQH 356 Query: 262 PWFRLNYVPIRAREEEEVNLDD 283 P+ + Y P D Sbjct: 357 PYINVWYDPAEVEAPPPQIYDK 378 >6CKI-A nrPDB Length = 316 Score = 238 bits (607), Expect = 5e-63, Method: Composition-based stats. Identities = 78/290 (26%), Positives = 128/290 (44%), Gaps = 38/290 (13%) Query: 11 YEVGR-TIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR-H 68 Y++ +GEG A+V+ N T A+KI+ K + ++ RE+ ++ + H Sbjct: 14 YQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQP---GHIRSRVFREVEMLYQCQGH 70 Query: 69 PNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCK 128 N++ L E + Y+V E + GG + I + E E+ Q + A+ H K Sbjct: 71 RNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHNK 130 Query: 129 GVYHRDLKPENLLLDTNGN---LKVSDFGLSALPQEGVE-------LLRTTCGTPNYVAP 178 G+ HRDLKPEN+L + +K+ DFGL + + + L T CG+ Y+AP Sbjct: 131 GIAHRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPELLTPCGSAEYMAP 190 Query: 179 EVL----SGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPG---------------LY 219 EV+ D+WS GVIL+++L+GY PF L+ Sbjct: 191 EVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQNMLF 250 Query: 220 RKINAAEFSCPP----WFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFR 265 I ++ P S K LI ++L + K R+ + + PW + Sbjct: 251 ESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQ 300 >5MJB-A nrPDB Length = 305 Score = 237 bits (606), Expect = 6e-63, Method: Composition-based stats. Identities = 61/261 (23%), Positives = 109/261 (41%), Gaps = 16/261 (6%) Query: 12 EVGRTIGEGTFAKVKFARNTDTGDN---VAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 ++ IG G F +V R G VAIK + + E SIM H Sbjct: 29 KIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLK--AGYSEKQRRDFLSEASIMGQFDH 86 Query: 69 PNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHK-GRLEESESRKYFQQLVDAVAHCHC 127 NI+RL V+ + I+ EF+ L + G+ + + + + + Sbjct: 87 RNIIRLEGVVTKSRPVMIITEFMENCALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLSE 146 Query: 128 KGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVE--LLRTTCG---TPNYVAPEVLS 182 HRDL N+L+++N KVSDFGLS Q+ ++ G + APE ++ Sbjct: 147 MNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIA 206 Query: 183 GQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAAEFSCPP--WFSAEVKF 239 + + SA+D+WS G++++ +++ G P+ + + I ++ PP A + Sbjct: 207 YRKF-TSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQ-DYRLPPPMDCPAALHQ 264 Query: 240 LIHRILDPNPKTRIQIQGIKK 260 L+ + +R + I Sbjct: 265 LMLDCWQKDRNSRPRFAEIVN 285 >2VWV-A nrPDB Length = 302 Score = 237 bits (605), Expect = 7e-63, Method: Composition-based stats. Identities = 62/258 (24%), Positives = 107/258 (41%), Gaps = 14/258 (5%) Query: 12 EVGRTIGEGTFAKVKFARNTDTGDN---VAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 ++ IG G F +V R G VAIK + R + E SIM H Sbjct: 19 KIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLK--GGYTERQRREFLSEASIMGQFEH 76 Query: 69 PNIVRLYEVLASPSKIYIVLEFVTGGELFDRIV-HKGRLEESESRKYFQQLVDAVAHCHC 127 PNI+RL V+ + + I+ EF+ G L + + G+ + + + + + Sbjct: 77 PNIIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGMRYLAE 136 Query: 128 KGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCG-----TPNYVAPEVLS 182 HRDL N+L+++N KVSDFGLS +E T + APE ++ Sbjct: 137 MSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTETSSLGGKIPIRWTAPEAIA 196 Query: 183 GQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINA-AEFSCPPWFSAEVKFL 240 + + SA+D WS G++++ +++ G P+ + + I PP + L Sbjct: 197 FRKF-TSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCPTSLHQL 255 Query: 241 IHRILDPNPKTRIQIQGI 258 + + R + + Sbjct: 256 MLDCWQKDRNARPRFPQV 273 >5L6P-A nrPDB Length = 298 Score = 237 bits (605), Expect = 7e-63, Method: Composition-based stats. Identities = 61/265 (23%), Positives = 110/265 (41%), Gaps = 16/265 (6%) Query: 8 VGKYEVGRTIGEGTFAKVKFARNTDTGDN---VAIKIMAKSTILKNRMVDQIKREISIMK 64 V ++ IG G F +V R G VAIK + R E SIM Sbjct: 18 VSCVKIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVG--YTERQRRDFLSEASIMG 75 Query: 65 IVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIV-HKGRLEESESRKYFQQLVDAVA 123 HPNI+RL V+ + I+ EF+ L + + G+ + + + + Sbjct: 76 QFDHPNIIRLEGVVTKSRPVMILTEFMENCALDSFLRLNDGQFTVIQLVGMLRGIAAGMK 135 Query: 124 HCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEG--VELLRTTCG---TPNYVAP 178 + HRDL N+L+++N KVSDFGLS ++ ++ G + AP Sbjct: 136 YLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTAP 195 Query: 179 EVLSGQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAAEFSCPP--WFSA 235 E ++ + + SA+D+WS G++++ +++ G P+ + + + ++ PP Sbjct: 196 EAIAYRKF-TSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVEQ-DYRLPPPMDCPT 253 Query: 236 EVKFLIHRILDPNPKTRIQIQGIKK 260 + L+ + R + I Sbjct: 254 ALHQLMLDCWVRDRNLRPKFSQIVN 278 >2XS0-A nrPDB Length = 386 Score = 237 bits (605), Expect = 7e-63, Method: Composition-based stats. Identities = 78/322 (24%), Positives = 127/322 (39%), Gaps = 55/322 (17%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 +Y+ + IG G V A + NVAIK +++ + RE+ +MK V H Sbjct: 27 RYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSR-PFQNQTHAKRAYRELVLMKCVNHK 85 Query: 70 NIVRLYEVL------ASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVA 123 NI+ L V +YIV+E + L I + L+ Q++ + Sbjct: 86 NIIGLLNVFTPQKSLEEFQDVYIVMELMDA-NLCQVIQME--LDHERMSYLLYQMLCGIK 142 Query: 124 HCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSG 183 H H G+ HRDLKP N+++ ++ LK+ DFGL+ ++ T Y APEV+ G Sbjct: 143 HLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF-MMVPFVVTRYYRAPEVILG 201 Query: 184 QGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRK-INAAEFSCPPWF--------- 233 GY DIWS G I+ ++ G + F TD + K I CP + Sbjct: 202 MGY-KENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQPTVRT 260 Query: 234 --------------------------------SAEVKFLIHRILDPNPKTRIQIQGIKKD 261 +++ + L+ ++L + RI + + Sbjct: 261 YVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQH 320 Query: 262 PWFRLNYVPIRAREEEEVNLDD 283 P+ + Y P A E + D Sbjct: 321 PYINVWYDPSEA-EAPPPKIPD 341 >4XLV-A nrPDB Length = 328 Score = 236 bits (603), Expect = 1e-62, Method: Composition-based stats. Identities = 64/281 (22%), Positives = 116/281 (41%), Gaps = 28/281 (9%) Query: 9 GKYEVGRTIGEGTFAKVKF--ARNTDTGD---NVAIKIMAKSTILKNRMVDQIKREISIM 63 K + R +G+G+F V AR+ G+ VA+K + +S L+ R+ + E S+M Sbjct: 39 EKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERI--EFLNEASVM 96 Query: 64 KIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVH----------KGRLEESESRK 113 K ++VRL V++ +V+E + G+L + + E + Sbjct: 97 KGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQ 156 Query: 114 YFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCG-- 171 ++ D +A+ + K HRDL N ++ + +K+ DFG++ E + G Sbjct: 157 MAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLL 216 Query: 172 TPNYVAPEVLSGQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAAEF-SC 229 ++APE L G +++D+WS GV+L+ I + P+ + + + + Sbjct: 217 PVRWMAPESLKD-GVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQ 275 Query: 230 PPWFSAEVKFLIHRILDPNPKTRIQIQGIKK------DPWF 264 P V L+ NP R I P F Sbjct: 276 PDNCPERVTDLMRMCWQFNPNMRPTFLEIVNLLKDDLHPSF 316 >4UYA-A nrPDB Length = 340 Score = 236 bits (602), Expect = 2e-62, Method: Composition-based stats. Identities = 68/267 (25%), Positives = 112/267 (41%), Gaps = 20/267 (7%) Query: 8 VGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMV-DQIKREISIMKIV 66 + E+ IG G F +V A G VA+K + + ++RE + ++ Sbjct: 25 FERLELKELIGAGGFGQVYRATW--QGQEVAVKAARQDPEQDAAAAAESVRREARLFAML 82 Query: 67 RHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCH 126 RHPNI+ L V + +VLEF GG L +R + R+ + Q+ + + H Sbjct: 83 RHPNIIELRGVCLQQPHLCLVLEFARGGAL-NRALAGRRIPPHVLVNWAVQIARGMLYLH 141 Query: 127 CKG---VYHRDLKPENLLLDT--------NGNLKVSDFGLSALPQEGVELLRTTCGTPNY 175 + + HRDLK N+LL N LK++DFGL+ ++ G + Sbjct: 142 EEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKMAT--AGAYAW 199 Query: 176 VAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYR--KINAAEFSCPPWF 233 +APEV+ + +DIWS GV+L+ +L G +P+ D + +N P Sbjct: 200 MAPEVIKSSLF-SKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLTLPIPSTC 258 Query: 234 SAEVKFLIHRILDPNPKTRIQIQGIKK 260 L+ +P R I + Sbjct: 259 PEPFAKLMKECWQQDPHIRPSFALILE 285 >2PSQ-A nrPDB Length = 370 Score = 235 bits (601), Expect = 2e-62, Method: Composition-based stats. Identities = 62/281 (22%), Positives = 120/281 (42%), Gaps = 31/281 (11%) Query: 9 GKYEVGRTIGEGTFAKVKFAR----NTDTGDN---VAIKIMAKSTILKNRMVDQIKREIS 61 K +G+ +GEG F +V A + D VA+K++ K+ + + E+ Sbjct: 81 DKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKD--LSDLVSEME 138 Query: 62 IMKIV-RHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHK-----------GRLEES 109 +MK++ +H NI+ L +Y+++E+ + G L + + + R+ E Sbjct: 139 MMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEE 198 Query: 110 ES-----RKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVE 164 + QL + + + HRDL N+L+ N +K++DFGL+ Sbjct: 199 QMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDY 258 Query: 165 LLRTTCG--TPNYVAPEVLSGQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRK 221 +TT G ++APE L + Y +D+WS GV+++ I G P+ + L++ Sbjct: 259 YKKTTNGRLPVKWMAPEALFDRVY-THQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKL 317 Query: 222 INAA-EFSCPPWFSAEVKFLIHRILDPNPKTRIQIQGIKKD 261 + P + E+ ++ P R + + +D Sbjct: 318 LKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVED 358 >5EFQ-A nrPDB Length = 347 Score = 235 bits (601), Expect = 2e-62, Method: Composition-based stats. Identities = 79/322 (24%), Positives = 131/322 (40%), Gaps = 49/322 (15%) Query: 6 RRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKI 65 R V K+++ IGEGT+ +V AR+ DTG+ VA+K + + + I REI I++ Sbjct: 8 RCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAI-REIKILRQ 66 Query: 66 VRHPNIVRLYEVLASPSK----------IYIVLEFVTG---GELFDRIVHKGRLEESESR 112 + H +I+ + E++ Y+V E++ G L +VH E+ + Sbjct: 67 LTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVH---FNENHIK 123 Query: 113 KYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALP-QEGVELLRTTCG 171 + +QL++ + +CH K HRD+K N+LL+ G +K++DFGL+ L E Sbjct: 124 SFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVI 183 Query: 172 TPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINA-AEFSCP 230 T Y PE+L G+ A D+WSCG IL + F I+ CP Sbjct: 184 TLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCP 243 Query: 231 P-----------------------------WFSAEVKFLIHRILDPNPKTRIQIQGIKKD 261 + A L +L +P R + + Sbjct: 244 AVWPDVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQC 303 Query: 262 PWFRLNYVPIRAREEEEVNLDD 283 + R + P + + D Sbjct: 304 EFLR-DVEPSKMPPPDLPLWQD 324 >2DQ7-X nrPDB Length = 283 Score = 235 bits (601), Expect = 3e-62, Method: Composition-based stats. Identities = 61/250 (24%), Positives = 110/250 (44%), Gaps = 12/250 (4%) Query: 12 EVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNI 71 ++ + +G G F +V + VAIK + T+ + E IMK ++H + Sbjct: 12 QLIKRLGNGQFGEVWMGTW-NGNTKVAIKTLKPGTMSP----ESFLEEAQIMKKLKHDKL 66 Query: 72 VRLYEVLASPSKIYIVLEFVTGGELFDRIVH-KGR-LEESESRKYFQQLVDAVAHCHCKG 129 V+LY V++ IYIV E++ G L D + +GR L+ Q+ +A+ Sbjct: 67 VQLYAVVSEE-PIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMN 125 Query: 130 VYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTP-NYVAPEVLSGQGYDG 188 HRDL+ N+L+ K++DFGL+ L ++ R P + APE G Sbjct: 126 YIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALY-GRFT 184 Query: 189 SAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAA-EFSCPPWFSAEVKFLIHRILD 246 +D+WS G++L ++ G +P+ + + ++ CP + L+ Sbjct: 185 IKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWK 244 Query: 247 PNPKTRIQIQ 256 +P+ R + Sbjct: 245 KDPEERPTFE 254 >1G3N-A nrPDB Length = 326 Score = 234 bits (598), Expect = 5e-62, Method: Composition-based stats. Identities = 75/294 (25%), Positives = 124/294 (42%), Gaps = 42/294 (14%) Query: 10 KYEVGRTIGEGTFAKVKFARN-TDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR- 67 +YE IGEG + KV AR+ + G VA+K + T + + I RE+++++ + Sbjct: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTI-REVAVLRHLET 70 Query: 68 --HPNIVRLYEVLA-----SPSKIYIVLEFVTGGELFDRIVH--KGRLEESESRKYFQQL 118 HPN+VRL++V +K+ +V E V +L + + + + QL Sbjct: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQL 129 Query: 119 VDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAP 178 + + H V HRDLKP+N+L+ ++G +K++DFGL+ + + L + T Y AP Sbjct: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQM-ALTSVVVTLWYRAP 188 Query: 179 EVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAA-----------EF 227 EVL Y + D+WS G I + F + KI + Sbjct: 189 EVLLQSSY-ATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDV 247 Query: 228 SCPP----------------WFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFR 265 + P K L+ + L NP RI P+F+ Sbjct: 248 ALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQ 301 >1K9A-A nrPDB Length = 450 Score = 234 bits (597), Expect = 7e-62, Method: Composition-based stats. Identities = 61/258 (23%), Positives = 114/258 (44%), Gaps = 16/258 (6%) Query: 8 VGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR 67 + + ++ +TIG+G F V G+ VA+K + + E S+M +R Sbjct: 192 MKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQ-----AFLAEASVMTQLR 244 Query: 68 HPNIVRLYEVL-ASPSKIYIVLEFVTGGELFDRIVHKGR--LEESESRKYFQQLVDAVAH 124 H N+V+L V+ +YIV E++ G L D + +GR L K+ + +A+ + Sbjct: 245 HSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEY 304 Query: 125 CHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQ 184 HRDL N+L+ + KVSDFGL+ + + + APE L + Sbjct: 305 LEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPV---KWTAPEALREK 361 Query: 185 GYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAA-EFSCPPWFSAEVKFLIH 242 + + +D+WS G++L+ I + G +P+ L + ++ + P V ++ Sbjct: 362 KF-STKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMK 420 Query: 243 RILDPNPKTRIQIQGIKK 260 + TR +++ Sbjct: 421 NCWHLDAATRPTFLQLRE 438 >4PDO-A nrPDB Length = 299 Score = 234 bits (597), Expect = 7e-62, Method: Composition-based stats. Identities = 65/262 (24%), Positives = 110/262 (41%), Gaps = 13/262 (4%) Query: 7 RVGKYEVGRTIGEGTFAKVKFARNT-DTGDN---VAIKIMAKSTILKNRMVDQIKREISI 62 + IG G F +V +G VAIK + K R+ E I Sbjct: 32 HPSCVTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRV--DFLGEAGI 89 Query: 63 MKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHK-GRLEESESRKYFQQLVDA 121 M H NI+RL V++ + I+ E++ G L + K G + + + Sbjct: 90 MGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAG 149 Query: 122 VAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCG---TPNYVAP 178 + + HRDL N+L+++N KVSDFGLS + ++ E TT G + AP Sbjct: 150 MKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAP 209 Query: 179 EVLSGQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAA-EFSCPPWFSAE 236 E +S + + SA+D+WS G++++ ++ G P+ E + + IN P + Sbjct: 210 EAISYRKF-TSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSA 268 Query: 237 VKFLIHRILDPNPKTRIQIQGI 258 + L+ + R + I Sbjct: 269 IYQLMMQCWQQERARRPKFADI 290 >3DLS-A nrPDB Length = 335 Score = 233 bits (596), Expect = 9e-62, Method: Composition-based stats. Identities = 80/263 (30%), Positives = 132/263 (50%), Gaps = 13/263 (4%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVD-----QIKREISIMK 64 KY +G G F V A + + V +K + K +L++ ++ ++ EI+I+ Sbjct: 25 KYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILS 84 Query: 65 IVRHPNIVRLYEVLASPSKIYIVLE-FVTGGELFDRIVHKGRLEESESRKYFQQLVDAVA 123 V H NI+++ ++ + +V+E +G +LF I RL+E + F+QLV AV Sbjct: 85 RVEHANIIKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYIFRQLVSAVG 144 Query: 124 HCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSG 183 + K + HRD+K EN+++ + +K+ DFG +A + G +L T CGT Y APEVL G Sbjct: 145 YLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERG-KLFYTFCGTIEYCAPEVLMG 203 Query: 184 QGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHR 243 Y G ++WS GV L+ ++ PF E + A P S E+ L+ Sbjct: 204 NPYRGPELEMWSLGVTLYTLVFEENPFCE------LEETVEAAIHPPYLVSKELMSLVSG 257 Query: 244 ILDPNPKTRIQIQGIKKDPWFRL 266 +L P P+ R ++ + DPW Sbjct: 258 LLQPVPERRTTLEKLVTDPWVTQ 280 >3QGY-A nrPDB Length = 286 Score = 233 bits (595), Expect = 1e-61, Method: Composition-based stats. Identities = 63/256 (24%), Positives = 108/256 (42%), Gaps = 10/256 (3%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 + + IG G F V + D VAIK + + ++ + D E +M + H Sbjct: 27 SELTFVQEIGSGQFGLVHLGYWLN-KDKVAIKTIKEGSMSE----DDFIEEAEVMMKLSH 81 Query: 69 PNIVRLYEVLASPSKIYIVLEFVTGGELFDRIV-HKGRLEESESRKYFQQLVDAVAHCHC 127 P +V+LY V + I +V EF+ G L D + +G + + +A+ Sbjct: 82 PKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEE 141 Query: 128 KGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTP-NYVAPEVLSGQGY 186 V HRDL N L+ N +KVSDFG++ + T P + +PEV S Y Sbjct: 142 ACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRY 201 Query: 187 DGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAA-EFSCPPWFSAEVKFLIHRI 244 S +D+WS GV+++ + + G +P+ + I+ P S V +++ Sbjct: 202 -SSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHC 260 Query: 245 LDPNPKTRIQIQGIKK 260 P+ R + + Sbjct: 261 WKERPEDRPAFSRLLR 276 >3ORP-A nrPDB Length = 311 Score = 233 bits (595), Expect = 1e-61, Method: Composition-based stats. Identities = 73/290 (25%), Positives = 129/290 (44%), Gaps = 17/290 (5%) Query: 1 MTKKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREI 60 MT +YE+G +G G ++V AR+ +VA+K++ + +RE Sbjct: 4 MTTPSHLSDRYELGEILGFGGMSEVHLARDLRDHRDVAVKVLRADLARDPSFYLRFRREA 63 Query: 61 SIMKIVRHPNIVRLYEVLASPSK----IYIVLEFVTGGELFDRIVHKGRLEESESRKYFQ 116 + HP IV +Y+ + + YIV+E+V G L D + +G + + + Sbjct: 64 QNAAALNHPAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVHTEGPMTPKRAIEVIA 123 Query: 117 QLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTT---CGTP 173 A+ H G+ HRD+KP N+++ +KV DFG++ + + T GT Sbjct: 124 DACQALNFSHQNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGTA 183 Query: 174 NYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGL-YRKINAAEFSCPP- 231 Y++PE G D +D++S G +L+ +L G PF+ + Y+ + E PP Sbjct: 184 QYLSPEQARGDSVDA-RSDVYSLGCVLYEVLTGEPPFTGDSPVSVAYQHVR--EDPIPPS 240 Query: 232 ----WFSAEVKFLIHRILDPNPKTRI-QIQGIKKDPWFRLNYVPIRAREE 276 SA++ ++ + L NP+ R ++ D N P A + Sbjct: 241 ARHEGLSADLDAVVLKALAKNPENRYQTAAEMRADLVRVHNGEPPEAPKV 290 >5U6B-A nrPDB Length = 307 Score = 233 bits (595), Expect = 1e-61, Method: Composition-based stats. Identities = 68/284 (23%), Positives = 120/284 (42%), Gaps = 21/284 (7%) Query: 13 VGRTIGEGTFAKVKFARNTDTG--DNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 +G+T+GEG F V + VA+K M + ++ ++ E MK HPN Sbjct: 27 LGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSE-LEDFLSEAVCMKEFDHPN 85 Query: 71 IVRLYEVLASPSK------IYIVLEFVTGGELFDRIVHKG------RLEESESRKYFQQL 118 ++RL V S+ ++L F+ G+L +++ L K+ + Sbjct: 86 VMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADI 145 Query: 119 VDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCG--TPNYV 176 + + K HRDL N +L+ N ++ V+DFGLS G + ++ Sbjct: 146 ASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWI 205 Query: 177 APEVLSGQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAA-EFSCPPWFS 234 A E L+ + Y S +D+WS GV ++ I G P+ + +Y + P Sbjct: 206 AIESLADRVY-TSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCL 264 Query: 235 AEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEE 278 + L+ R + NP+ R +++D L +P A+E +E Sbjct: 265 DGLYALMSRCWELNPQDRPSFTELREDLENTLKALP-PAQEPDE 307 >3LM0-A nrPDB Length = 327 Score = 233 bits (595), Expect = 1e-61, Method: Composition-based stats. Identities = 77/309 (24%), Positives = 141/309 (45%), Gaps = 20/309 (6%) Query: 3 KKMRRVGKYEVG--RTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREI 60 + M + + + +G G FA V+ + TG A K + K ++ +I EI Sbjct: 21 QSMENFNNFYILTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQD-CRAEILHEI 79 Query: 61 SIMKIVRH-PNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHK--GRLEESESRKYFQQ 117 +++++ + P ++ L+EV + S+I ++LE+ GGE+F + + + E++ + +Q Sbjct: 80 AVLELAKSCPRVINLHEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQ 139 Query: 118 LVDAVAHCHCKGVYHRDLKPENLLLDT---NGNLKVSDFGLSALPQEGVELLRTTCGTPN 174 +++ V + H + H DLKP+N+LL + G++K+ DFG+S E LR GTP Sbjct: 140 ILEGVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACE-LREIMGTPE 198 Query: 175 YVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPW-- 232 Y+APE+L+ +A D+W+ G+I +++L PF D Y I+ Sbjct: 199 YLAPEILNYDPI-TTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETF 257 Query: 233 --FSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRL-----NYVPIRAREEEEVNLDDIR 285 S I +L NP+ R + W + + P + +R Sbjct: 258 SSVSQLATDFIQSLLVKNPEKRPTAEICLSHSWLQQWDFENLFHPEETSSSSQTQDHSVR 317 Query: 286 AVFDGIEGS 294 + D S Sbjct: 318 SSEDKTSKS 326 >4GS6-A nrPDB Length = 315 Score = 233 bits (594), Expect = 1e-61, Method: Composition-based stats. Identities = 74/283 (26%), Positives = 118/283 (41%), Gaps = 26/283 (9%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 + EV +G G F V A+ +VAIK + E+ + V HP Sbjct: 10 EIEVEEVVGRGAFGVVCKAKWRA--KDVAIKQI-----ESESERKAFIVELRQLSRVNHP 62 Query: 70 NIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEE---SESRKYFQQLVDAVAHCH 126 NIV+LY + + +V+E+ GG L++ + L + + + Q VA+ H Sbjct: 63 NIVKLYGACL--NPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLH 120 Query: 127 C---KGVYHRDLKPENLLLDTNGNL-KVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLS 182 K + HRDLKP NLLL G + K+ DFG + Q + G+ ++APEV Sbjct: 121 SMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTH---MTNNKGSAAWMAPEVFE 177 Query: 183 GQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWF---SAEVKF 239 G Y D++S G+IL+ ++ PF E P + PP ++ Sbjct: 178 GSNY-SEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIES 236 Query: 240 LIHRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEVNLD 282 L+ R +P R ++ I K + Y P +E + Sbjct: 237 LMTRCWSKDPSQRPSMEEIVKIMTHLMRYFP---GADEPLQYP 276 >4K33-A nrPDB Length = 325 Score = 232 bits (593), Expect = 2e-61, Method: Composition-based stats. Identities = 57/280 (20%), Positives = 116/280 (41%), Gaps = 31/280 (11%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDN-------VAIKIMAKSTILKNRMVDQIKREISI 62 + +G+ +GEG F +V A + VA+K++ K+ + + E+ + Sbjct: 37 RLTLGKPLGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKD--LSDLVSEMEM 94 Query: 63 MKIV-RHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHK----------------GR 105 MK++ +H NI+ L +Y+++E+ G L + + + + Sbjct: 95 MKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTSKPPEEQ 154 Query: 106 LEESESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVEL 165 L + Q+ + + + HRDL N+L+ + +K++DFGL+ Sbjct: 155 LTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYY 214 Query: 166 LRTTCG--TPNYVAPEVLSGQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKI 222 TT G ++APE L + Y +D+WS GV+L+ I G P+ + L++ + Sbjct: 215 KETTNGRLPVKWMAPEALFDRVY-THQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLL 273 Query: 223 NAA-EFSCPPWFSAEVKFLIHRILDPNPKTRIQIQGIKKD 261 P + ++ ++ P R + + +D Sbjct: 274 KEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVED 313 >4HZS-A nrPDB Length = 341 Score = 232 bits (593), Expect = 2e-61, Method: Composition-based stats. Identities = 66/284 (23%), Positives = 118/284 (41%), Gaps = 15/284 (5%) Query: 10 KYEVGRTIGEGTFAKVKFAR-NTDTGDNV--AIKIMAKSTILKNRMVDQIKREISIMKIV 66 + +G+G+F V+ + +G V A+K + + + +D RE++ M + Sbjct: 13 DLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSL 72 Query: 67 RHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIV-HKGRLEESESRKYFQQLVDAVAHC 125 H N++RLY V+ +P + +V E G L DR+ H+G +Y Q+ + + + Sbjct: 73 DHRNLIRLYGVVLTP-PMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYL 131 Query: 126 HCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELL---RTTCGTPNYVAPEVLS 182 K HRDL NLLL T +K+ DFGL + + + APE L Sbjct: 132 ESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLK 191 Query: 183 GQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINA--AEFSCPPWFSAEVKF 239 + + A+D W GV L+ + G P+ + + KI+ P ++ Sbjct: 192 TRTF-SHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYN 250 Query: 240 LIHRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEVNLDD 283 ++ + P+ R ++ F L P R ++ D Sbjct: 251 VMVQCWAHKPEDRPTFVALRD---FLLEAQPTDMRALQDFEEPD 291 >3GC0-A nrPDB Length = 329 Score = 232 bits (592), Expect = 2e-61, Method: Composition-based stats. Identities = 72/295 (24%), Positives = 119/295 (40%), Gaps = 37/295 (12%) Query: 8 VGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR 67 + +Y +GEGT+ +V A +T T + VAIK + + I RE+S++K ++ Sbjct: 33 IDRYRRITKLGEGTYGEVYKAIDTVTNETVAIKRIRLEHEEEGVPGTAI-REVSLLKELQ 91 Query: 68 HPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHC 127 H NI+ L V+ +++++ E+ +L + + + + QL++ V CH Sbjct: 92 HRNIIELKSVIHHNHRLHLIFEYAEN-DLKKYMDKNPDVSMRVIKSFLYQLINGVNFCHS 150 Query: 128 KGVYHRDLKPENLLLD-----TNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLS 182 + HRDLKP+NLLL LK+ DFGL+ + T Y PE+L Sbjct: 151 RRCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQFTHEIITLWYRPPEILL 210 Query: 183 GQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINA-----------AEFSCPP 231 G + ++ DIWS I +L F KI + P Sbjct: 211 GSRHYSTSVDIWSIACIWAEMLMKTPLFPGDSEIDQLFKIFEVLGLPDDTTWPGVTALPD 270 Query: 232 W---FSAEVKFLIHR----------------ILDPNPKTRIQIQGIKKDPWFRLN 267 W F + R +L+ +P RI + + P+F N Sbjct: 271 WKQSFPKFRGKTLKRVLGALLDDEGLDLLTAMLEMDPVKRISAKNALEHPYFSHN 325 >1BYG-A nrPDB Length = 278 Score = 232 bits (592), Expect = 3e-61, Method: Composition-based stats. Identities = 60/258 (23%), Positives = 113/258 (43%), Gaps = 16/258 (6%) Query: 8 VGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR 67 + + ++ +TIG+G F V G+ VA+K + + E S+M +R Sbjct: 20 MKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQ-----AFLAEASVMTQLR 72 Query: 68 HPNIVRLYEVL-ASPSKIYIVLEFVTGGELFDRIVHKGR--LEESESRKYFQQLVDAVAH 124 H N+V+L V+ +YIV E++ G L D + +GR L K+ + +A+ + Sbjct: 73 HSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEY 132 Query: 125 CHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQ 184 HRDL N+L+ + KVSDFGL+ + + + APE L + Sbjct: 133 LEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPV---KWTAPEALREK 189 Query: 185 GYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAA-EFSCPPWFSAEVKFLIH 242 + + +D+WS G++L+ I + G +P+ L + ++ + P V ++ Sbjct: 190 KF-STKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMK 248 Query: 243 RILDPNPKTRIQIQGIKK 260 + R +++ Sbjct: 249 NCWHLDAAMRPSFLQLRE 266 >4NST-A nrPDB Length = 351 Score = 232 bits (592), Expect = 3e-61, Method: Composition-based stats. Identities = 74/304 (24%), Positives = 127/304 (41%), Gaps = 48/304 (15%) Query: 6 RRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKI 65 R V K+++ IGEGT+ +V A++ DTG+ VA+K + + + I REI I++ Sbjct: 10 RCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAI-REIKILRQ 68 Query: 66 VRHPNIVRLYEVLASPSK----------IYIVLEFVTG---GELFDRIVHKGRLEESESR 112 + H ++V + E++ Y+V E++ G L +VH E + Sbjct: 69 LIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVH---FSEDHIK 125 Query: 113 KYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQ-EGVELLRTTCG 171 + +QL++ + +CH K HRD+K N+LL+ +G +K++DFGL+ L E Sbjct: 126 SFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVI 185 Query: 172 TPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINA-AEFSCP 230 T Y PE+L G+ A D+WSCG IL + F I+ CP Sbjct: 186 TLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCP 245 Query: 231 -----------------------------PWFSAEVKFLIHRILDPNPKTRIQIQGIKKD 261 + + L+ +L +P R + + Sbjct: 246 AVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQS 305 Query: 262 PWFR 265 + + Sbjct: 306 DFLK 309 >3FI2-A nrPDB Length = 353 Score = 232 bits (592), Expect = 3e-61, Method: Composition-based stats. Identities = 74/326 (22%), Positives = 129/326 (39%), Gaps = 54/326 (16%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 +Y+ + IG G V A + NVAIK +++ + RE+ +MK V H Sbjct: 25 RYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSR-PFQNQTHAKRAYRELVLMKCVNHK 83 Query: 70 NIVRLYEVL------ASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVA 123 NI+ L V +Y+V+E + L I + L+ Q++ + Sbjct: 84 NIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQME--LDHERMSYLLYQMLCGIK 140 Query: 124 HCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSG 183 H H G+ HRDLKP N+++ ++ LK+ DFGL+ ++ T Y APEV+ G Sbjct: 141 HLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF-MMTPYVVTRYYRAPEVILG 199 Query: 184 QGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRK-INAAEFSCPPWF--------- 233 GY DIWS G I+ ++ + F D + K I CP + Sbjct: 200 MGY-KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRN 258 Query: 234 --------------------------------SAEVKFLIHRILDPNPKTRIQIQGIKKD 261 +++ + L+ ++L +P RI + + Sbjct: 259 YVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQH 318 Query: 262 PWFRLNYVPIRAREEEEVNLDDIRAV 287 P+ + Y +E E +++ + + Sbjct: 319 PYINVWYXXXXXXDEREHTIEEWKEL 344 >3SXS-A nrPDB Length = 268 Score = 232 bits (591), Expect = 3e-61, Method: Composition-based stats. Identities = 60/255 (23%), Positives = 117/255 (45%), Gaps = 10/255 (3%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 + + + +G G F VK + D VA+K++ + ++ + D+ +E M + H Sbjct: 8 EEITLLKELGSGQFGVVKLGKWKGQYD-VAVKMIKEGSMSE----DEFFQEAQTMMKLSH 62 Query: 69 PNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGR-LEESESRKYFQQLVDAVAHCHC 127 P +V+ Y V + IYIV E+++ G L + + G+ LE S+ + + + +A Sbjct: 63 PKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLES 122 Query: 128 KGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTP-NYVAPEVLSGQGY 186 HRDL N L+D + +KVSDFG++ + + P + APEV Y Sbjct: 123 HQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKY 182 Query: 187 DGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAAEFSCPPWF-SAEVKFLIHRI 244 S +D+W+ G++++ + + G +P+ + K++ P S + +++ Sbjct: 183 -SSKSDVWAFGILMWEVFSLGKMPYDLYTNSEVVLKVSQGHRLYRPHLASDTIYQIMYSC 241 Query: 245 LDPNPKTRIQIQGIK 259 P+ R Q + Sbjct: 242 WHELPEKRPTFQQLL 256 >5G6V-A nrPDB Length = 324 Score = 231 bits (590), Expect = 4e-61, Method: Composition-based stats. Identities = 74/328 (22%), Positives = 134/328 (40%), Gaps = 41/328 (12%) Query: 8 VGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR 67 + Y +GEGT+A V ++ T + VA+K + + RE+S++K ++ Sbjct: 1 METYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLE--HEEGAPCTAIREVSLLKDLK 58 Query: 68 HPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRL-EESESRKYFQQLVDAVAHCH 126 H NIV L++++ + + +V E++ +L + G + + + QL+ +A+CH Sbjct: 59 HANIVTLHDIIHTEKSLTLVFEYLDK-DLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCH 117 Query: 127 CKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGY 186 + V HRDLKP+NLL++ G LK++DFGL+ + T Y P++L G Sbjct: 118 RQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYDNEVVTLWYRPPDILLGSTD 177 Query: 187 DGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKI-------------------NAAEF 227 + D+W G I + + G F + + I + Sbjct: 178 YSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTY 237 Query: 228 SCP-----------PWFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREE 276 + P P ++ L+ ++L + RI + K P+F I Sbjct: 238 NYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIH---- 293 Query: 277 EEVNLDDIRAVFDGIEGSYVAENVERND 304 L D ++F E E R+ Sbjct: 294 ---KLPDTTSIFALKEIQLQKEASLRSA 318 >4O2Z-A nrPDB Length = 377 Score = 231 bits (590), Expect = 4e-61, Method: Composition-based stats. Identities = 63/312 (20%), Positives = 108/312 (34%), Gaps = 38/312 (12%) Query: 6 RRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKI 65 KY + + +G G + + DTG+ V+IK + ++ REI +M+ Sbjct: 42 EVPSKYTLLKILGMGAYGIACSCLDGDTGEKVSIKKC-RDVFRDVEDGKRVLREIDMMRF 100 Query: 66 VRHPNIVRLYEV-------LASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQL 118 H N++ + + S +Y+V + ++ + + LEES + + Q+ Sbjct: 101 FHHENLLNVVNILPPLKREYHSFEDVYVVTPLMDV-DMNVVLRSRQVLEESHMQYFVYQI 159 Query: 119 VDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAP 178 + + + H V HRDLKP NL+ + + LK+ DFGLS L T Y P Sbjct: 160 LRGLKYLHSANVAHRDLKPANLVTNISCELKIIDFGLSRSVDVPYSELTDYVITRWYRPP 219 Query: 179 EVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINA-------------- 224 E+L +A DIWS G I + F + R I Sbjct: 220 ELLLENTNYSTAVDIWSVGCIFAEMYNRKPVFPGRNTMDQLRMIAQHIGKPPASIVEHRE 279 Query: 225 ----------AEFSCPPWFS-----AEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYV 269 + P E + ++ +P R + P+ + Sbjct: 280 ALEKLNELPDGSLNIPKLVPGLAGNTEGIDFLSKMWTLDPSKRPTAADMLAHPYLAHLHD 339 Query: 270 PIRAREEEEVNL 281 L Sbjct: 340 EEDEPTCPCPFL 351 >5KMM-A nrPDB Length = 329 Score = 231 bits (589), Expect = 5e-61, Method: Composition-based stats. Identities = 55/267 (20%), Positives = 100/267 (37%), Gaps = 28/267 (10%) Query: 16 TIGEGTFAKVKFARNTD-----TGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 +GEG F KV A + VA+K + ++ +RE ++ +++H + Sbjct: 42 ELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEA---SESARQDFQREAELLTMLQHQH 98 Query: 71 IVRLYEVLASPSKIYIVLEFVTGGELFDRIVHK---------------GRLEESESRKYF 115 IVR + V + +V E++ G+L + G L + Sbjct: 99 IVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVA 158 Query: 116 QQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRT--TCGTP 173 Q+ + + HRDL N L+ +K+ DFG+S T Sbjct: 159 SQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPI 218 Query: 174 NYVAPEVLSGQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAA-EFSCPP 231 ++ PE + + + + +D+WS GV+L+ I G P+ + I E P Sbjct: 219 RWMPPESILYRKF-TTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPR 277 Query: 232 WFSAEVKFLIHRILDPNPKTRIQIQGI 258 EV ++ P+ R I+ + Sbjct: 278 ACPPEVYAIMRGCWQREPQQRHSIKDV 304 >3MIA-A nrPDB Length = 351 Score = 231 bits (589), Expect = 5e-61, Method: Composition-based stats. Identities = 76/315 (24%), Positives = 123/315 (39%), Gaps = 51/315 (16%) Query: 7 RVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIV 66 V KYE IG+GTF +V AR+ TG VA+K + K REI I++++ Sbjct: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMEN-EKEGFPITALREIKILQLL 73 Query: 67 RHPNIVRLYEVLASP--------SKIYIVLEFVTG---GELFDRIVHKGRLEESESRKYF 115 +H N+V L E+ + IY+V +F G L + +V SE ++ Sbjct: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK---FTLSEIKRVM 130 Query: 116 QQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALP----QEGVELLRTTCG 171 Q L++ + + H + HRD+K N+L+ +G LK++DFGL+ Sbjct: 131 QMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVV 190 Query: 172 TPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYL----------------------P 209 T Y PE+L G+ G D+W G I+ + P Sbjct: 191 TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITP 250 Query: 210 --FSETDLPGLYRKI-------NAAEFSCPPWF-SAEVKFLIHRILDPNPKTRIQIQGIK 259 + D LY K+ + + LI ++L +P RI Sbjct: 251 EVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDAL 310 Query: 260 KDPWFRLNYVPIRAR 274 +F + +P + Sbjct: 311 NHDFFWSDPMPSDLK 325 >3PG1-A nrPDB Length = 362 Score = 231 bits (589), Expect = 6e-61, Method: Composition-based stats. Identities = 76/345 (22%), Positives = 136/345 (39%), Gaps = 57/345 (16%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAK--------STILKNRMVDQIKREISI 62 Y V R I G++ V +++ G VAIK + + + + + ++ REI + Sbjct: 24 YTVQRFISSGSYGAVCAGVDSE-GIPVAIKRVFNTVSDGRTVNILSDSFLCKRVLREIRL 82 Query: 63 MKIVRHPNIVRLYEVLAS-----PSKIYIVLEFVTGGELFDRIVHKGRL--EESESRKYF 115 + HPNI+ L ++ K+Y+V E + +++H R+ + + Sbjct: 83 LNHFHHPNILGLRDIFVHFEEPAMHKLYLVTELMRTD--LAQVIHDQRIVISPQHIQYFM 140 Query: 116 QQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGT-PN 174 ++ + H GV HRDL P N+LL N ++ + DF L+ ++ + +T T Sbjct: 141 YHILLGLHVLHEAGVVHRDLHPGNILLADNNDITICDFNLAR--EDTADANKTHYVTHRW 198 Query: 175 YVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAE-------- 226 Y APE++ D+WS G ++ + F + KI Sbjct: 199 YRAPELVMQFKGFTKLVDMWSAGCVMAEMFNRKALFRGSTFYNQLNKIVEVVGTPKIEDV 258 Query: 227 --FSCP----------------------PWFSAEVKFLIHRILDPNPKTRIQIQGIKKDP 262 FS P P LI ++L+ NP+ RI + + P Sbjct: 259 VMFSSPSARDYLRNSLSNVPARAWTAVVPTADPVALDLIAKMLEFNPQRRISTEQALRHP 318 Query: 263 WFRLNYVPIRARE--EEEVNLDD-IRAVFDGIEGSYVAENVERND 304 +F + P+ E E + D+ + V+D + + AE ND Sbjct: 319 YFESLFDPLDLTEGLSERFHFDESVTDVYD-MHKIFTAEVERFND 362 >1FVR-A nrPDB Length = 327 Score = 230 bits (588), Expect = 7e-61, Method: Composition-based stats. Identities = 66/273 (24%), Positives = 105/273 (38%), Gaps = 27/273 (9%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNV--AIKIMAKSTILKNRMVDQIKREISIMKIV 66 + IGEG F +V AR G + AIK M E+ ++ + Sbjct: 25 NDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMK--EYASKDDHRDFAGELEVLCKL 82 Query: 67 -RHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEES---------------- 109 HPNI+ L +Y+ +E+ G L D + LE Sbjct: 83 GHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQ 142 Query: 110 ESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTT 169 + + + + + K HRDL N+L+ N K++DFGLS + V + +T Sbjct: 143 QLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSR--GQEVYVKKTM 200 Query: 170 CGTP-NYVAPEVLSGQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAA-E 226 P ++A E L+ Y + +D+WS GV+L+ I++ G P+ LY K+ Sbjct: 201 GRLPVRWMAIESLNYSVYTTN-SDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYR 259 Query: 227 FSCPPWFSAEVKFLIHRILDPNPKTRIQIQGIK 259 P EV L+ + P R I Sbjct: 260 LEKPLNCDDEVYDLMRQCWREKPYERPSFAQIL 292 >2PL0-A nrPDB Length = 289 Score = 230 bits (588), Expect = 8e-61, Method: Composition-based stats. Identities = 59/249 (23%), Positives = 111/249 (44%), Gaps = 12/249 (4%) Query: 12 EVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNI 71 ++ +G G F +V + VA+K + + ++ D E ++MK ++H + Sbjct: 26 KLVERLGAGQFGEVWMGYY-NGHTKVAVKSLKQGSMSP----DAFLAEANLMKQLQHQRL 80 Query: 72 VRLYEVLASPSKIYIVLEFVTGGELFDRIVHKG--RLEESESRKYFQQLVDAVAHCHCKG 129 VRLY V+ IYI+ E++ G L D + +L ++ Q+ + +A + Sbjct: 81 VRLYAVVTQE-PIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERN 139 Query: 130 VYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTP-NYVAPEVLSGQGYDG 188 HRDL+ N+L+ + K++DFGL+ L ++ R P + APE ++ G Sbjct: 140 YIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINY-GTFT 198 Query: 189 SAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAA-EFSCPPWFSAEVKFLIHRILD 246 +D+WS G++L I+ G +P+ P + + + P E+ L+ Sbjct: 199 IKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWK 258 Query: 247 PNPKTRIQI 255 P+ R Sbjct: 259 ERPEDRPTF 267 >3A4O-X nrPDB Length = 286 Score = 230 bits (587), Expect = 1e-60, Method: Composition-based stats. Identities = 57/250 (22%), Positives = 114/250 (45%), Gaps = 13/250 (5%) Query: 12 EVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNI 71 ++ + +G G F +V ++ VA+K + T+ V E ++MK ++H + Sbjct: 16 KLVKRLGAGQFGEVWMGYYNNS-TKVAVKTLKPGTMS----VQAFLEEANLMKTLQHDKL 70 Query: 72 VRLYEVLASPSKIYIVLEFVTGGELFDRIVHK--GRLEESESRKYFQQLVDAVAHCHCKG 129 VRLY V+ IYI+ E++ G L D + G++ + + Q+ + +A+ K Sbjct: 71 VRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKN 130 Query: 130 VYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTP-NYVAPEVLSGQGYDG 188 HRDL+ N+L+ + K++DFGL+ + ++ R P + APE ++ G Sbjct: 131 YIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINF-GCFT 189 Query: 189 SAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAAEFSCP--PWFSAEVKFLIHRIL 245 +D+WS G++L+ I+ G +P+ + ++ + P E+ ++ Sbjct: 190 IKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQG-YRMPRVENCPDELYDIMKMCW 248 Query: 246 DPNPKTRIQI 255 + R Sbjct: 249 KEKAEERPTF 258 >3BEA-A nrPDB Length = 333 Score = 230 bits (587), Expect = 1e-60, Method: Composition-based stats. Identities = 59/275 (21%), Positives = 110/275 (40%), Gaps = 28/275 (10%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDN-----VAIKIMAKSTILKNRMVDQIKREISIM 63 + G+T+G G F KV A G VA+K++ + + + + E+ IM Sbjct: 46 NNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEK--EALMSELKIM 103 Query: 64 KIV-RHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGR--------------LEE 108 + +H NIV L + ++ E+ G+L + + K R L Sbjct: 104 SHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKSRVLETDPAFAIANSTLST 163 Query: 109 SESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSA-LPQEGVELLR 167 + + Q+ +A K HRD+ N+LL K+ DFGL+ + + +++ Sbjct: 164 RDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVK 223 Query: 168 TTCGTP-NYVAPEVLSGQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAA 225 P ++APE + Y +D+WS G++L+ I + G P+ + + K+ Sbjct: 224 GNARLPVKWMAPESIFDCVY-TVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKD 282 Query: 226 EFSC--PPWFSAEVKFLIHRILDPNPKTRIQIQGI 258 + P + + ++ P R Q I Sbjct: 283 GYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQI 317 >2OGV-A nrPDB Length = 317 Score = 230 bits (586), Expect = 1e-60, Method: Composition-based stats. Identities = 59/271 (21%), Positives = 110/271 (40%), Gaps = 24/271 (8%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDN-----VAIKIMAKSTILKNRMVDQIKREISIM 63 + G+T+G G F KV A G VA+K++ + + + + E+ IM Sbjct: 38 NNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEK--EALMSELKIM 95 Query: 64 KIV-RHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHK----------GRLEESESR 112 + +H NIV L + ++ E+ G+L + + K LE + Sbjct: 96 SHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEADLDKEDGRPLELRDLL 155 Query: 113 KYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSA-LPQEGVELLRTTCG 171 + Q+ +A K HRD+ N+LL K+ DFGL+ + + +++ Sbjct: 156 HFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNAR 215 Query: 172 TP-NYVAPEVLSGQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAAEFSC 229 P ++APE + Y +D+WS G++L+ I + G P+ + + K+ + Sbjct: 216 LPVKWMAPESIFDCVY-TVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQM 274 Query: 230 --PPWFSAEVKFLIHRILDPNPKTRIQIQGI 258 P + + ++ P R Q I Sbjct: 275 AQPAFAPKNIYSIMQACWALEPTHRPTFQQI 305 >4H1J-A nrPDB Length = 293 Score = 229 bits (585), Expect = 1e-60, Method: Composition-based stats. Identities = 62/253 (24%), Positives = 115/253 (45%), Gaps = 11/253 (4%) Query: 13 VGRTIGEGTFAKVKFAR---NTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 + R +GEG F +V + NVA+K K L N+ ++ E IMK + HP Sbjct: 28 LNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNK--EKFMSEAVIMKNLDHP 85 Query: 70 NIVRLYEVLASPSKIYIVLEFVTGGELFDRI-VHKGRLEESESRKYFQQLVDAVAHCHCK 128 +IV+L ++ +I++E GEL + +K L+ Y Q+ A+A+ Sbjct: 86 HIVKLIGIIEEE-PTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESI 144 Query: 129 GVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTP-NYVAPEVLSGQGYD 187 HRD+ N+L+ + +K+ DFGLS ++ + P +++PE ++ + + Sbjct: 145 NCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESINFRRF- 203 Query: 188 GSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAAE-FSCPPWFSAEVKFLIHRIL 245 +A+D+W V ++ IL+ G PF + + + + P + L+ R Sbjct: 204 TTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCW 263 Query: 246 DPNPKTRIQIQGI 258 D +P R + + Sbjct: 264 DYDPSDRPRFTEL 276 >2HK5-A nrPDB Length = 270 Score = 229 bits (585), Expect = 2e-60, Method: Composition-based stats. Identities = 59/253 (23%), Positives = 117/253 (46%), Gaps = 12/253 (4%) Query: 12 EVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNI 71 ++ + +G G F +V A + VA+K M ++ V+ E ++MK ++H + Sbjct: 18 KLEKKLGAGQFGEVWMATY-NKHTKVAVKTMKPGSMS----VEAFLAEANVMKTLQHDKL 72 Query: 72 VRLYEVLASPSKIYIVLEFVTGGELFDRIVHKG--RLEESESRKYFQQLVDAVAHCHCKG 129 V+L+ V+ + IYI+ EF+ G L D + + + + Q+ + +A + Sbjct: 73 VKLHAVV-TKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRN 131 Query: 130 VYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTP-NYVAPEVLSGQGYDG 188 HRDL+ N+L+ + K++DFGL+ + ++ R P + APE ++ + Sbjct: 132 YIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSF-T 190 Query: 189 SAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAA-EFSCPPWFSAEVKFLIHRILD 246 +D+WS G++L I+ G +P+ P + R + P E+ ++ R Sbjct: 191 IKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWK 250 Query: 247 PNPKTRIQIQGIK 259 P+ R + I+ Sbjct: 251 NRPEERPTFEYIQ 263 >1U54-B nrPDB Length = 291 Score = 228 bits (583), Expect = 3e-60, Method: Composition-based stats. Identities = 66/277 (23%), Positives = 116/277 (41%), Gaps = 15/277 (5%) Query: 10 KYEVGRTIGEGTFAKVKFAR-NTDTGDNV--AIKIMAKSTILKNRMVDQIKREISIMKIV 66 + +G+G+F V+ + +G V A+K + + + +D RE++ M + Sbjct: 19 DLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSL 78 Query: 67 RHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIV-HKGRLEESESRKYFQQLVDAVAHC 125 H N++RLY V+ +P + +V E G L DR+ H+G +Y Q+ + + + Sbjct: 79 DHRNLIRLYGVVLTP-PMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYL 137 Query: 126 HCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELL---RTTCGTPNYVAPEVLS 182 K HRDL NLLL T +K+ DFGL + + + APE L Sbjct: 138 ESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLK 197 Query: 183 GQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINA--AEFSCPPWFSAEVKF 239 + + A+D W GV L+ + G P+ + + KI+ P ++ Sbjct: 198 TRTF-SHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYN 256 Query: 240 LIHRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREE 276 ++ + P+ R ++ F L P R E Sbjct: 257 VMVQCWAHKPEDRPTFVALRD---FLLEAQPTDMRAE 290 >5EG3-A nrPDB Length = 334 Score = 228 bits (582), Expect = 3e-60, Method: Composition-based stats. Identities = 61/281 (21%), Positives = 118/281 (41%), Gaps = 31/281 (11%) Query: 9 GKYEVGRTIGEGTFAKVKFAR----NTDTGDN---VAIKIMAKSTILKNRMVDQIKREIS 61 K +G+ +GEG F +V A + D VA+K++ K+ + + E+ Sbjct: 35 DKLTLGKPLGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKD--LSDLVSEME 92 Query: 62 IMKIV-RHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHK-----------GRLEES 109 +MK++ +H NI+ L +Y+++ + + G L + + + R+ E Sbjct: 93 MMKMIGKHKNIINLLGACTQDGPLYVIVAYASKGNLREYLRARRPPGMELSPDINRVPEE 152 Query: 110 ES-----RKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVE 164 + QL + + + HRDL N+L+ N +K++DFGL+ Sbjct: 153 QMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDF 212 Query: 165 LLRTTCG--TPNYVAPEVLSGQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRK 221 TT G ++APE L + Y +D+WS GV+++ I G P+ + L++ Sbjct: 213 FKETTNGRLPVKWMAPEALFDRVY-THQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKL 271 Query: 222 INAA-EFSCPPWFSAEVKFLIHRILDPNPKTRIQIQGIKKD 261 + P + E+ ++ P R + + +D Sbjct: 272 LKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVED 312 >5X5O-A nrPDB Length = 310 Score = 228 bits (582), Expect = 3e-60, Method: Composition-based stats. Identities = 60/259 (23%), Positives = 108/259 (41%), Gaps = 21/259 (8%) Query: 7 RVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIV 66 + + G G+F V A+ VA+K + K I++E I+ ++ Sbjct: 13 KFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLK-----------IEKEAEILSVL 61 Query: 67 RHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRI--VHKGRLEESESRKYFQQLVDAVAH 124 H NI++ Y V+ P IV E+ + G L+D I ++ + + + + Sbjct: 62 SHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHY 121 Query: 125 CHCK---GVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVL 181 H + V HRDLK N+++ +G LK+ DFG S + + GT ++APEV+ Sbjct: 122 LHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHM--SLVGTFPWMAPEVI 179 Query: 182 SGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKI--NAAEFSCPPWFSAEVKF 239 D +S GV+L+ +L +PF + + + + P Sbjct: 180 QSLP-VSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAE 238 Query: 240 LIHRILDPNPKTRIQIQGI 258 L+H+ + + K R + I Sbjct: 239 LLHQCWEADAKKRPSFKQI 257 >1LUF-A nrPDB Length = 343 Score = 228 bits (581), Expect = 4e-60, Method: Composition-based stats. Identities = 61/280 (21%), Positives = 106/280 (37%), Gaps = 36/280 (12%) Query: 9 GKYEVGRTIGEGTFAKVKFARNT-----DTGDNVAIKIMAKSTILKNRMVDQIKREISIM 63 E R IGEG F +V AR + VA+K++ + M +RE ++M Sbjct: 47 NNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASAD--MQADFQREAALM 104 Query: 64 KIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVH--------------------- 102 +PNIV+L V A + ++ E++ G+L + + Sbjct: 105 AEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRARVS 164 Query: 103 ---KGRLEESESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALP 159 L +E +Q+ +A+ + HRDL N L+ N +K++DFGLS Sbjct: 165 SPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNI 224 Query: 160 QEGVELLRTT--CGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILA-GYLPFSETDLP 216 ++ PE + Y + +D+W+ GV+L+ I + G P+ Sbjct: 225 YSADYYKADGNDAIPIRWMPPESIFYNRY-TTESDVWAYGVVLWEIFSYGLQPYYGMAHE 283 Query: 217 GLYRKINAAE-FSCPPWFSAEVKFLIHRILDPNPKTRIQI 255 + + +CP E+ L+ P R Sbjct: 284 EVIYYVRDGNILACPENCPLELYNLMRLCWSKLPADRPSF 323 >3QUP-A nrPDB Length = 323 Score = 227 bits (580), Expect = 7e-60, Method: Composition-based stats. Identities = 59/269 (21%), Positives = 116/269 (43%), Gaps = 21/269 (7%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTG---DNVAIKIMAKSTILKNRMVDQIKREISIMKIV 66 ++ +GR +G+G F V+ A+ VA+K++ K+ I+ + +++ RE + MK Sbjct: 24 QFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKML-KADIIASSDIEEFLREAACMKEF 82 Query: 67 RHPNIVRLYEVLASPSK------IYIVLEFVTGGELFDRIV------HKGRLEESESRKY 114 HP++ +L V ++L F+ G+L ++ + L ++ Sbjct: 83 DHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLVRF 142 Query: 115 FQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCG--T 172 + + + + HRDL N +L + + V+DFGLS G + Sbjct: 143 MVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLP 202 Query: 173 PNYVAPEVLSGQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRK-INAAEFSCP 230 ++A E L+ Y +D+W+ GV ++ I+ G P++ + +Y I P Sbjct: 203 VKWLALESLADNLY-TVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQP 261 Query: 231 PWFSAEVKFLIHRILDPNPKTRIQIQGIK 259 P EV L+++ +PK R ++ Sbjct: 262 PECMEEVYDLMYQCWSADPKQRPSFTCLR 290 >4AN9-A nrPDB Length = 301 Score = 227 bits (579), Expect = 7e-60, Method: Composition-based stats. Identities = 67/260 (25%), Positives = 116/260 (44%), Gaps = 8/260 (3%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 +E +G G V + +G +A K++ +K + +QI RE+ ++ Sbjct: 9 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE--IKPAIRNQIIRELQVLHECNS 66 Query: 69 PNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHC-HC 127 P IV Y S +I I +E + GG L + GR+ E K ++ + + Sbjct: 67 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREK 126 Query: 128 KGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYD 187 + HRD+KP N+L+++ G +K+ DFG+S + E+ GT +Y++PE L G Y Sbjct: 127 HKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID--EMANEFVGTRSYMSPERLQGTHY- 183 Query: 188 GSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPW--FSAEVKFLIHRIL 245 +DIWS G+ L + G P + L I P FS E + +++ L Sbjct: 184 SVQSDIWSMGLSLVEMAVGRYPRPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFVNKCL 243 Query: 246 DPNPKTRIQIQGIKKDPWFR 265 NP R ++ + + + Sbjct: 244 IKNPAERADLKQLMVHAFIK 263 >3KRL-A nrPDB Length = 335 Score = 227 bits (579), Expect = 9e-60, Method: Composition-based stats. Identities = 58/277 (20%), Positives = 110/277 (39%), Gaps = 30/277 (10%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDN-----VAIKIMAKSTILKNRMVDQIKREISIM 63 + G+T+G G F KV A G VA+K++ + + + + E+ IM Sbjct: 46 NNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEK--EALMSELKIM 103 Query: 64 KIV-RHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHK----------------GRL 106 + +H NIV L + ++ E+ G+L + + K +L Sbjct: 104 SHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKRPPGLEYSYNPSHNPEEQL 163 Query: 107 EESESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSA-LPQEGVEL 165 + + Q+ +A K HRD+ N+LL K+ DFGL+ + + + Sbjct: 164 SSRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYI 223 Query: 166 LRTTCGTP-NYVAPEVLSGQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKIN 223 ++ P ++APE + Y +D+WS G++L+ I + G P+ + + K+ Sbjct: 224 VKGNARLPVKWMAPESIFDCVY-TVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLV 282 Query: 224 AAEFSC--PPWFSAEVKFLIHRILDPNPKTRIQIQGI 258 + P + + ++ P R Q I Sbjct: 283 KDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQI 319 >5AMN-A nrPDB Length = 299 Score = 226 bits (577), Expect = 1e-59, Method: Composition-based stats. Identities = 62/268 (23%), Positives = 114/268 (42%), Gaps = 22/268 (8%) Query: 13 VGRTIGEGTFAKVKFARNTDTG-----DNVAIKIMAKSTILKNRMVDQIKREISIMKIVR 67 +G+T+GEG F KV A VA+K++ ++ + + E +++K V Sbjct: 27 LGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENA--SPSELRDLLSEFNVLKQVN 84 Query: 68 HPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGR----------LEESESRKYFQQ 117 HP++++LY + + +++E+ G L + + L + + Q Sbjct: 85 HPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYPDERALTMGDLISFAWQ 144 Query: 118 LVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCG--TPNY 175 + + + + HRDL N+L+ +K+SDFGLS E ++ + G + Sbjct: 145 ISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKW 204 Query: 176 VAPEVLSGQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAA-EFSCPPWF 233 +A E L Y + +D+WS GV+L+ I+ G P+ L+ + P Sbjct: 205 MAIESLFDHIY-TTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNC 263 Query: 234 SAEVKFLIHRILDPNPKTRIQIQGIKKD 261 S E+ L+ + P R I KD Sbjct: 264 SEEMYRLMLQCWKQEPDKRPVFADISKD 291 >3BBT-B nrPDB Length = 328 Score = 225 bits (575), Expect = 2e-59, Method: Composition-based stats. Identities = 57/256 (22%), Positives = 116/256 (45%), Gaps = 13/256 (5%) Query: 12 EVGRTIGEGTFAKVKFARNTDTGDNV----AIKIMAKSTILKNRMVDQIKREISIMKIVR 67 + + +G G F V G+ V AIKI+ ++T K + + E IM + Sbjct: 18 KRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANV--EFMDEALIMASMD 75 Query: 68 HPNIVRLYEVLASPSKIYIVLEFVTGGELFDRI-VHKGRLEESESRKYFQQLVDAVAHCH 126 HP++VRL V SP+ I +V + + G L + + HK + + Q+ + + Sbjct: 76 HPHLVRLLGVCLSPT-IQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLE 134 Query: 127 CKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCG--TPNYVAPEVLSGQ 184 + + HRDL N+L+ + ++K++DFGL+ L + + G ++A E + + Sbjct: 135 ERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYR 194 Query: 185 GYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAAE-FSCPPWFSAEVKFLIH 242 + +D+WS GV ++ ++ G P+ + + E PP + +V ++ Sbjct: 195 KF-THQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMV 253 Query: 243 RILDPNPKTRIQIQGI 258 + + +R + + + Sbjct: 254 KCWMIDADSRPKFKEL 269 >4R7H-A nrPDB Length = 343 Score = 225 bits (575), Expect = 3e-59, Method: Composition-based stats. Identities = 60/284 (21%), Positives = 111/284 (39%), Gaps = 37/284 (13%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDN-----VAIKIMAKSTILKNRMVDQIKREISIM 63 + G+T+G G F KV A G VA+K++ + + + + E+ IM Sbjct: 50 NNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEK--EALMSELKIM 107 Query: 64 KIV-RHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHK------------------- 103 + +H NIV L + ++ E+ T G+L + + K Sbjct: 108 SHLGQHENIVNLLGACTHGGPVLVITEYCTYGDLLNFLRRKAEAMLGPSLSPGQDPEGLD 167 Query: 104 ----GRLEESESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSA-L 158 LE + + Q+ +A K HRD+ N+LL K+ DFGL+ + Sbjct: 168 KEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDI 227 Query: 159 PQEGVELLRTTCGTP-NYVAPEVLSGQGYDGSAADIWSCGVILFVILA-GYLPFSETDLP 216 + +++ P ++APE + Y +D+WS G++L+ I + G P+ + Sbjct: 228 MNDSNYIVKGNARLPVKWMAPESIFDSVY-TVQSDVWSYGILLWEIFSLGLNPYPGILVN 286 Query: 217 GLYRKINAAEFSC--PPWFSAEVKFLIHRILDPNPKTRIQIQGI 258 + K+ + P + + ++ P R Q I Sbjct: 287 SKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQI 330 >3G0E-A nrPDB Length = 336 Score = 225 bits (574), Expect = 3e-59, Method: Composition-based stats. Identities = 62/281 (22%), Positives = 113/281 (40%), Gaps = 32/281 (11%) Query: 9 GKYEVGRTIGEGTFAKVKFAR-----NTDTGDNVAIKIMAKSTILKNRMVDQIKREISIM 63 + G+T+G G F KV A +D VA+K++ S L R + + E+ ++ Sbjct: 46 NRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTER--EALMSELKVL 103 Query: 64 KIV-RHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGR----------------- 105 + H NIV L ++ E+ G+L + + K Sbjct: 104 SYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKTSPAIMEDDEL 163 Query: 106 -LEESESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQ-EGV 163 L+ + + Q+ +A K HRDL N+LL K+ DFGL+ + + Sbjct: 164 ALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSN 223 Query: 164 ELLRTTCGTP-NYVAPEVLSGQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRK 221 +++ P ++APE + Y +D+WS G+ L+ + + G P+ + + K Sbjct: 224 YVVKGNARLPVKWMAPESIFNCVY-TFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYK 282 Query: 222 INAAEFSC--PPWFSAEVKFLIHRILDPNPKTRIQIQGIKK 260 + F P AE+ ++ D +P R + I + Sbjct: 283 MIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQ 323 >6DBM-A nrPDB Length = 318 Score = 225 bits (574), Expect = 3e-59, Method: Composition-based stats. Identities = 70/275 (25%), Positives = 117/275 (42%), Gaps = 30/275 (10%) Query: 10 KY-EVGRTIGEGTFAKVKFA----RNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMK 64 +Y + R +GEG F KV N TG+ VA+K + ++R K+EI I++ Sbjct: 31 RYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAGPQHRSG--WKQEIDILR 88 Query: 65 IVRHPNIVRLYEVLASPS--KIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAV 122 + H +I++ + +V+E+V G L D + + ++ + QQ+ + + Sbjct: 89 TLYHEHIIKYKGCCEDAGAASLQLVMEYVPLGSLRDYLPRH-SIGLAQLLLFAQQICEGM 147 Query: 123 AHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLR---TTCGTPNYVAPE 179 A+ H + HRDL N+LLD + +K+ DFGL+ EG E R + APE Sbjct: 148 AYLHSQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPE 207 Query: 180 VLSGQGYDGSAADIWSCGVILFVILAG-----YLP--F--------SETDLPGLYRKINA 224 L + A+D+WS GV L+ +L P F + + L + Sbjct: 208 CLKEYKFY-YASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLER 266 Query: 225 AE-FSCPPWFSAEVKFLIHRILDPNPKTRIQIQGI 258 E P AEV L+ + R + + Sbjct: 267 GERLPRPDKCPAEVYHLMKNCWETEASFRPTFENL 301 >4OLI-A nrPDB Length = 645 Score = 225 bits (574), Expect = 3e-59, Method: Composition-based stats. Identities = 68/275 (24%), Positives = 117/275 (42%), Gaps = 30/275 (10%) Query: 10 KY-EVGRTIGEGTFAKVKFA----RNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMK 64 +Y + R +GEG F KV N TG+ VA+K + ++R K+EI I++ Sbjct: 353 RYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSG--WKQEIDILR 410 Query: 65 IVRHPNIVRLYEVLASPSK--IYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAV 122 + H +I++ + + +V+E+V G L D + + ++ + QQ+ + + Sbjct: 411 TLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRH-SIGLAQLLLFAQQICEGM 469 Query: 123 AHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLR---TTCGTPNYVAPE 179 A+ H + HR+L N+LLD + +K+ DFGL+ EG E R + APE Sbjct: 470 AYLHSQHYIHRNLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPE 529 Query: 180 VLSGQGYDGSAADIWSCGVILFVILAG-----YLP--F--------SETDLPGLYRKINA 224 L + A+D+WS GV L+ +L P F + + L + Sbjct: 530 CLKEYKFY-YASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLER 588 Query: 225 AE-FSCPPWFSAEVKFLIHRILDPNPKTRIQIQGI 258 E P EV L+ + R + + Sbjct: 589 GERLPRPDKCPCEVYHLMKNCWETEASFRPTFENL 623 Score = 129 bits (324), Expect = 3e-30, Method: Composition-based stats. Identities = 52/247 (21%), Positives = 92/247 (37%), Gaps = 24/247 (9%) Query: 28 ARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYEVLASPSKIYIV 87 R+ V +K++ S + S+M V H ++ ++ V + +V Sbjct: 88 GRDRGQELRVVLKVLDPSHH---DIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMV 144 Query: 88 LEFVTGGELFDRIVH-KGRLEESESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLL---- 142 E+V G L + +G + + QQL A+++ K + H ++ N+LL Sbjct: 145 TEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLG 204 Query: 143 ---DTNGNLKVSDFGL---SALPQEGVELLRTTCGTPNYVAPEVLSGQGYD-GSAADIWS 195 T+ +K+SD G+ + +E VE + ++APE L G +A D W Sbjct: 205 LAEGTSPFIKLSDPGVGLGALSREERVERIP-------WLAPECLPGGANSLSTAMDKWG 257 Query: 196 CGVILFVILA-GYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILDPNPKTRIQ 254 G L I G P + P ++ L + L P R Sbjct: 258 FGATLLEICFDGEAPLQSRSPSE-KEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPS 316 Query: 255 IQGIKKD 261 + I +D Sbjct: 317 FRTILRD 323 >5O2B-A nrPDB Length = 285 Score = 225 bits (573), Expect = 4e-59, Method: Composition-based stats. Identities = 65/265 (24%), Positives = 123/265 (46%), Gaps = 17/265 (6%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 K+++ +G G F V +T+T VA + + K + K E ++K ++HP Sbjct: 19 KFDI--ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQ-QRFKEEAEMLKGLQHP 75 Query: 70 NIVRLYEVLAS----PSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHC 125 NIVR Y+ S I +V E +T G L + ++ R + +Q++ + Sbjct: 76 NIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFL 135 Query: 126 HCK--GVYHRDLKPENLLLD-TNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLS 182 H + + HRDLK +N+ + G++K+ D GL+ L + ++ GTP ++APE Sbjct: 136 HTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMR--TSFAKSVIGTPEFMAPE--M 191 Query: 183 GQGYDGSAADIWSCGVILFVILAGYLPFSE-TDLPGLYRKINAA--EFSCPPWFSAEVKF 239 + + + D+++ G+ + + P+SE + +YRK+ + S EVK Sbjct: 192 YEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVTDPEVKE 251 Query: 240 LIHRILDPNPKTRIQIQGIKKDPWF 264 +I + N R+ I+ + +F Sbjct: 252 IIEGCIRQNKSERLSIRDLLNHAFF 276 >5O2C-A nrPDB Length = 380 Score = 224 bits (571), Expect = 7e-59, Method: Composition-based stats. Identities = 65/265 (24%), Positives = 123/265 (46%), Gaps = 17/265 (6%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 K+++ +G G F V +T+T VA + + K + K E ++K ++HP Sbjct: 28 KFDI--ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQ-QRFKEEAEMLKGLQHP 84 Query: 70 NIVRLYEVLAS----PSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHC 125 NIVR Y+ S I +V E +T G L + ++ R + +Q++ + Sbjct: 85 NIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFL 144 Query: 126 HCK--GVYHRDLKPENLLLD-TNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLS 182 H + + HRDLK +N+ + G++K+ D GL+ L + ++ GTP ++APE Sbjct: 145 HTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMR--TSFAKSVIGTPEFMAPE--M 200 Query: 183 GQGYDGSAADIWSCGVILFVILAGYLPFSE-TDLPGLYRKINAA--EFSCPPWFSAEVKF 239 + + + D+++ G+ + + P+SE + +YRK+ + S EVK Sbjct: 201 YEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVTDPEVKE 260 Query: 240 LIHRILDPNPKTRIQIQGIKKDPWF 264 +I + N R+ I+ + +F Sbjct: 261 IIEGCIRQNKSERLSIRDLLNHAFF 285 >3AOX-A nrPDB Length = 344 Score = 224 bits (571), Expect = 7e-59, Method: Composition-based stats. Identities = 64/310 (20%), Positives = 109/310 (35%), Gaps = 35/310 (11%) Query: 12 EVGRTIGEGTFAKVKFAR-----NTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIV 66 + R +G G F +V + N + VA+K + + ++ + E I+ Sbjct: 50 TLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDEL--DFLMEALIISKF 107 Query: 67 RHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIV-------HKGRLEESESRKYFQQLV 119 H NIVR V +I+LE + GG+L + L + + + Sbjct: 108 NHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIA 167 Query: 120 DAVAHCHCKGVYHRDLKPENLLLDTNG---NLKVSDFGLSALPQEGVELLRTTCG--TPN 174 + HRD+ N LL G K+ DFG++ + C Sbjct: 168 CGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVK 227 Query: 175 YVAPEVLSGQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAAEFSCPPW- 232 ++ PE +G S D WS GV+L+ I + GY+P+ + + + PP Sbjct: 228 WMPPEAFM-EGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKN 286 Query: 233 FSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEVNLDDIRAVFDGIE 292 V ++ + P+ R N+ I R E D+ IE Sbjct: 287 CPGPVYRIMTQCWQHQPEDRP-------------NFAIILERIEYCTQDPDVINTALPIE 333 Query: 293 GSYVAENVER 302 + E E+ Sbjct: 334 YGPLVEEEEK 343 >2W96-B nrPDB Length = 306 Score = 224 bits (571), Expect = 7e-59, Method: Composition-based stats. Identities = 71/296 (23%), Positives = 116/296 (39%), Gaps = 41/296 (13%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR- 67 +YE IG G + V AR+ +G VA+K + + + + RE+++++ + Sbjct: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPISTV-REVALLRRLEA 62 Query: 68 --HPNIVRLYEVLASPS-----KIYIVLEFVTGGELFDRIVH--KGRLEESESRKYFQQL 118 HPN+VRL +V A+ K+ +V E V +L + L + +Q Sbjct: 63 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQF 121 Query: 119 VDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAP 178 + + H + HRDLKPEN+L+ + G +K++DFGL+ + + L T Y AP Sbjct: 122 LRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQM-ALDPVVVTLWYRAP 180 Query: 179 EVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAA-----------EF 227 EVL Y + D+WS G I + F KI + Sbjct: 181 EVLLQSTY-ATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDV 239 Query: 228 SCP----------------PWFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLN 267 S P P L+ +L NP RI + + + Sbjct: 240 SLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKD 295 >6FEX-A nrPDB Length = 321 Score = 224 bits (571), Expect = 7e-59, Method: Composition-based stats. Identities = 54/297 (18%), Positives = 98/297 (32%), Gaps = 46/297 (15%) Query: 9 GKYEVGRTIGEGTFAKVKFAR--------------NTDTGD--NVAIKIMAKSTILKNRM 52 + +GEG F +V N G VA+KI+ Sbjct: 16 SRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDA--TKNA 73 Query: 53 VDQIKREISIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHK--------- 103 + +E+ IM ++ PNI+RL V + ++ +++ G+L + Sbjct: 74 RNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEG 133 Query: 104 ----GRLEESESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALP 159 + Q+ + + HRDL N L+ N +K++DFG+S Sbjct: 134 APGDPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNL 193 Query: 160 QEGVELLRT--TCGTPNYVAPEVLSGQGYDGSAADIWSCGVILFV--ILAGYLPFSETDL 215 G ++A E + G +A+D+W+ GV L+ +L PF + Sbjct: 194 YAGDYYRVQGRAVLPIRWMAWECIL-MGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTD 252 Query: 216 PGLYRKI--------NAAEFSCPPWFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWF 264 + S PP + L+ R + R + + Sbjct: 253 EQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQL--HRFL 307 >4XUF-A nrPDB Length = 297 Score = 223 bits (569), Expect = 1e-58, Method: Composition-based stats. Identities = 61/281 (21%), Positives = 114/281 (40%), Gaps = 37/281 (13%) Query: 12 EVGRTIGEGTFAKVKFARN---TDTG--DNVAIKIMAKSTILKNRMVDQIKREISIMKIV 66 E G+ +G G F KV A + TG VA+K++ + R + + E+ +M + Sbjct: 12 EFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSER--EALMSELKMMTQL 69 Query: 67 -RHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIV-HKGRLEESES------------- 111 H NIV L IY++ E+ G+L + + + + E E Sbjct: 70 GSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRLEEEED 129 Query: 112 ---------RKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSA-LPQE 161 + Q+ + K HRDL N+L+ +K+ DFGL+ + + Sbjct: 130 LNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSD 189 Query: 162 GVELLRTTCGTP-NYVAPEVLSGQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLY 219 ++R P ++APE L +G +D+WS G++L+ I + G P+ + + Sbjct: 190 SNYVVRGNARLPVKWMAPESLF-EGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANF 248 Query: 220 RKINAAEFSC--PPWFSAEVKFLIHRILDPNPKTRIQIQGI 258 K+ F P + + E+ ++ + + R + Sbjct: 249 YKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNL 289 >4Y93-A nrPDB Length = 446 Score = 223 bits (569), Expect = 1e-58, Method: Composition-based stats. Identities = 59/254 (23%), Positives = 111/254 (43%), Gaps = 10/254 (3%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 + +G G F VK+ + D VAIK++ + ++ + D+ E +M + H Sbjct: 189 DLTFLKELGTGQFGVVKYGKWRGQYD-VAIKMIKEGSMSE----DEFIEEAKVMMNLSHE 243 Query: 70 NIVRLYEVLASPSKIYIVLEFVTGGELFDRIVH-KGRLEESESRKYFQQLVDAVAHCHCK 128 +V+LY V I+I+ E++ G L + + + R + + + + + +A+ + K Sbjct: 244 KLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESK 303 Query: 129 GVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTP-NYVAPEVLSGQGYD 187 HRDL N L++ G +KVSDFG++ + T P + +PEVL + Sbjct: 304 QFLHRDLAARNCLVNDQGVVKVSDFGMTRYVLDDEYTSSTGSKFPVKWASPEVLMYSKF- 362 Query: 188 GSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAA-EFSCPPWFSAEVKFLIHRIL 245 S +DIW+ GV+++ I + G +P+ I P S V +++ Sbjct: 363 SSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLPRPHLASERVYAIMYSCW 422 Query: 246 DPNPKTRIQIQGIK 259 R + + Sbjct: 423 HEKADERPTFKILL 436 >2I6L-A nrPDB Length = 320 Score = 223 bits (568), Expect = 2e-58, Method: Composition-based stats. Identities = 74/314 (23%), Positives = 122/314 (38%), Gaps = 53/314 (16%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 +Y + +G G V A + D VAIK + + + V REI I++ + H Sbjct: 11 SRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKI---VLTDPQSVKHALREIKIIRRLDH 67 Query: 69 PNIVRLY--------------EVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKY 114 NIV+++ L + +YIV E++ +L + ++ +G L E +R + Sbjct: 68 DNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMET-DLAN-VLEQGPLLEEHARLF 125 Query: 115 FQQLVDAVAHCHCKGVYHRDLKPENLLLD-TNGNLKVSDFGLSALPQEGVEL---LRTTC 170 QL+ + + H V HRDLKP NL ++ + LK+ DFGL+ + L Sbjct: 126 MYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGL 185 Query: 171 GTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSE------------------ 212 T Y +P +L A D+W+ G I +L G F+ Sbjct: 186 VTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVH 245 Query: 213 -TDLPGLYRKI------NAAEFSCP-----PWFSAEVKFLIHRILDPNPKTRIQIQGIKK 260 D L I + E P P S E + +IL +P R+ + Sbjct: 246 EEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREAVDFLEQILTFSPMDRLTAEEALS 305 Query: 261 DPWFRLNYVPIRAR 274 P+ + P+ Sbjct: 306 HPYMSIYSFPMDEP 319 >4E7W-A nrPDB Length = 394 Score = 223 bits (568), Expect = 2e-58, Method: Composition-based stats. Identities = 83/318 (26%), Positives = 130/318 (40%), Gaps = 52/318 (16%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 Y + IG G+F V A+ ++ D VAIK + + KN RE+ IM+IV+HPN Sbjct: 42 YTNCKVIGNGSFGVVFQAKLVES-DEVAIKKVLQDKRFKN-------RELQIMRIVKHPN 93 Query: 71 IVRLYEVLASPSK------IYIVLEFVT---GGELFDRIVHKGRLEESESRKYFQQLVDA 121 +V L S + +VLE+V K + + Y QL+ + Sbjct: 94 VVDLKAFFYSNGDKKDEVFLNLVLEYVPETVYRASRHYAKLKQTMPMLLIKLYMYQLLRS 153 Query: 122 VAHCHCKGVYHRDLKPENLLLDT-NGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEV 180 +A+ H G+ HRD+KP+NLLLD +G LK+ DFG + + G + C + Y APE+ Sbjct: 154 LAYIHSIGICHRDIKPQNLLLDPPSGVLKLIDFGSAKILIAGEPNVSYIC-SRYYRAPEL 212 Query: 181 LSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAA--------------- 225 + G + DIWS G ++ ++ G F +I Sbjct: 213 IFGATNYTTNIDIWSTGCVMAELMQGQPLFPGESGIDQLVEIIKVLGTPSREQIKTMNPN 272 Query: 226 --EFSCP------------PWFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVPI 271 E P P + LI R+L+ P R+ P+F + Sbjct: 273 YMEHKFPQIRPHPFSKVFRPRTPPDAIDLISRLLEYTPSARLTAIEALCHPFF----DEL 328 Query: 272 RAREEEEVNLDDIRAVFD 289 R E N ++ +F+ Sbjct: 329 RTGEARMPNGRELPPLFN 346 >5AIR-A nrPDB Length = 430 Score = 222 bits (567), Expect = 2e-58, Method: Composition-based stats. Identities = 85/318 (26%), Positives = 127/318 (39%), Gaps = 51/318 (16%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 Y + IG G+F V A+ D+G+ VAIK + + KN RE+ IM+ + H N Sbjct: 66 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN-------RELQIMRKLDHCN 118 Query: 71 IVRLYEVLASPSK------IYIVLEFVT---GGELFDRIVHKGRLEESESRKYFQQLVDA 121 IVRL S + + +VL++V K L + Y QL + Sbjct: 119 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRS 178 Query: 122 VAHCHCKGVYHRDLKPENLLLDTN-GNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEV 180 +A+ H G+ HRD+KP+NLLLD + LK+ DFG + G + C + Y APE+ Sbjct: 179 LAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYIC-SRYYRAPEL 237 Query: 181 LSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAA--------------- 225 + G S+ D+WS G +L +L G F +I Sbjct: 238 IFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPN 297 Query: 226 --EFSCP------------PWFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVPI 271 EF P P E L R+L+ P R+ +F + Sbjct: 298 YTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF----DEL 353 Query: 272 RAREEEEVNLDDIRAVFD 289 R + N D A+F+ Sbjct: 354 RDPNVKLPNGRDTPALFN 371 >2OZO-A nrPDB Length = 613 Score = 222 bits (566), Expect = 2e-58, Method: Composition-based stats. Identities = 64/248 (25%), Positives = 110/248 (44%), Gaps = 12/248 (4%) Query: 16 TIGEGTFAKVKFA--RNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVR 73 +G G F V+ R +VAIK++ + T + +++ RE IM + +P IVR Sbjct: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGT--EKADTEEMMREAQIMHQLDNPYIVR 400 Query: 74 LYEVLASPSKIYIVLEFVTGGELFDRIV-HKGRLEESESRKYFQQLVDAVAHCHCKGVYH 132 L V + + + +V+E GG L +V + + S + Q+ + + K H Sbjct: 401 LIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVH 459 Query: 133 RDLKPENLLLDTNGNLKVSDFGLSALP--QEGVELLRTTCGTP-NYVAPEVLSGQGYDGS 189 R+L N+LL K+SDFGLS + R+ P + APE ++ + + S Sbjct: 460 RNLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKF-SS 518 Query: 190 AADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAAE-FSCPPWFSAEVKFLIHRILDP 247 +D+WS GV ++ L+ G P+ + P + I + CPP E+ L+ Sbjct: 519 RSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIY 578 Query: 248 NPKTRIQI 255 + R Sbjct: 579 KWEDRPDF 586 >5X02-A nrPDB Length = 347 Score = 222 bits (566), Expect = 3e-58, Method: Composition-based stats. Identities = 61/281 (21%), Positives = 114/281 (40%), Gaps = 37/281 (13%) Query: 12 EVGRTIGEGTFAKVKFARN---TDTG--DNVAIKIMAKSTILKNRMVDQIKREISIMKIV 66 E G+ +G G F KV A + TG VA+K++ + R + + E+ +M + Sbjct: 51 EFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSER--EALMSELKMMTQL 108 Query: 67 -RHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIV-HKGRLEESES------------- 111 H NIV L IY++ E+ G+L + + + + E E Sbjct: 109 GSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRLEEEED 168 Query: 112 ---------RKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSA-LPQE 161 + Q+ + K HRDL N+L+ +K+ DFGL+ + + Sbjct: 169 LNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSD 228 Query: 162 GVELLRTTCGTP-NYVAPEVLSGQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLY 219 ++R P ++APE L +G +D+WS G++L+ I + G P+ + + Sbjct: 229 SNYVVRGNARLPVKWMAPESLF-EGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANF 287 Query: 220 RKINAAEFSC--PPWFSAEVKFLIHRILDPNPKTRIQIQGI 258 K+ F P + + E+ ++ + + R + Sbjct: 288 YKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNL 328 >3CJF-A nrPDB Length = 309 Score = 222 bits (565), Expect = 3e-58, Method: Composition-based stats. Identities = 58/277 (20%), Positives = 108/277 (38%), Gaps = 27/277 (9%) Query: 9 GKYEVGRTIGEGTFAKVKFAR-----NTDTGDNVAIKIMAKSTILKNRMVDQIKREISIM 63 + +G+ +G G F +V A T T VA+K++ + + E+ I+ Sbjct: 27 DRLNLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEH--RALMSELKIL 84 Query: 64 -KIVRHPNIVRLYEVLASPS-KIYIVLEFVTGGELFDRIVHKGR------------LEES 109 I H N+V L P + +++EF G L + K L Sbjct: 85 IHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKDLYKDFLTLE 144 Query: 110 ESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSA-LPQEGVELLRT 168 Y Q+ + + HRDL N+LL +K+ DFGL+ + ++ + + Sbjct: 145 HLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKG 204 Query: 169 TCGTP-NYVAPEVLSGQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLY-RKINAA 225 P ++APE + + Y +D+WS GV+L+ I + G P+ + + R++ Sbjct: 205 DARLPLKWMAPETIFDRVY-TIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEG 263 Query: 226 -EFSCPPWFSAEVKFLIHRILDPNPKTRIQIQGIKKD 261 P + + E+ + P R + + Sbjct: 264 TRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEH 300 >5FM2-A nrPDB Length = 355 Score = 222 bits (565), Expect = 3e-58, Method: Composition-based stats. Identities = 62/282 (21%), Positives = 114/282 (40%), Gaps = 36/282 (12%) Query: 13 VGRTIGEGTFAKVKFARNTDTG-----DNVAIKIMAKSTILKNRMVDQIKREISIMKIVR 67 +G+T+GEG F KV A VA+K++ ++ + + E +++K V Sbjct: 68 LGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENA--SPSELRDLLSEFNVLKQVN 125 Query: 68 HPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGR---------------------- 105 HP++++LY + + +++E+ G L + + Sbjct: 126 HPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDE 185 Query: 106 --LEESESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGV 163 L + + Q+ + + + HRDL N+L+ +K+SDFGLS E Sbjct: 186 RALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEED 245 Query: 164 ELLRTTCG--TPNYVAPEVLSGQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYR 220 ++ + G ++A E L Y + +D+WS GV+L+ I+ G P+ L+ Sbjct: 246 SYVKRSQGRIPVKWMAIESLFDHIY-TTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFN 304 Query: 221 KINAA-EFSCPPWFSAEVKFLIHRILDPNPKTRIQIQGIKKD 261 + P S E+ L+ + P R I KD Sbjct: 305 LLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKD 346 >6GVJ-A nrPDB Length = 429 Score = 222 bits (565), Expect = 3e-58, Method: Composition-based stats. Identities = 72/278 (25%), Positives = 129/278 (46%), Gaps = 21/278 (7%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR-HP 69 Y + + IG G +KV N + AIK + N+ +D + EI+ + ++ H Sbjct: 146 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEA-DNQTLDSYRNEIAYLNKLQQHS 203 Query: 70 N-IVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCK 128 + I+RLY+ + IY+V+E +L + K ++ E + Y++ +++AV H Sbjct: 204 DKIIRLYDYEITDQYIYMVME-CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQH 262 Query: 129 GVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELL--RTTCGTPNYVAPEVLSGQG- 185 G+ H DLKP N L+ +G LK+ DFG++ Q + + GT NY+ PE + Sbjct: 263 GIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSS 321 Query: 186 ---------YDGSAADIWSCGVILFVILAGYLPFSE--TDLPGLYRKIN-AAEFSCPPWF 233 +D+WS G IL+ + G PF + + L+ I+ E P Sbjct: 322 SRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIP 381 Query: 234 SAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVPI 271 +++ ++ L +PK RI I + P+ ++ P+ Sbjct: 382 EKDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQTHPV 419 >6BSD-A nrPDB Length = 876 Score = 222 bits (565), Expect = 4e-58, Method: Composition-based stats. Identities = 54/303 (17%), Positives = 98/303 (32%), Gaps = 52/303 (17%) Query: 9 GKYEVGRTIGEGTFAKVKFAR--------------NTDTGD--NVAIKIMAKSTILKNRM 52 + +GEG F +V N G VA+KI+ Sbjct: 571 SRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDA--TKNA 628 Query: 53 VDQIKREISIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHK--------- 103 + +E+ IM ++ PNI+RL V + ++ +++ G+L + Sbjct: 629 RNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEG 688 Query: 104 ----------GRLEESESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDF 153 + Q+ + + HRDL N L+ N +K++DF Sbjct: 689 APGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADF 748 Query: 154 GLSALPQEGVELLRT--TCGTPNYVAPEVLSGQGYDGSAADIWSCGVILFV--ILAGYLP 209 G+S G ++A E + G +A+D+W+ GV L+ +L P Sbjct: 749 GMSRNLYAGDYYRVQGRAVLPIRWMAWECIL-MGKFTTASDVWAFGVTLWEVLMLCRAQP 807 Query: 210 FSETDLPGLYRKI--------NAAEFSCPPWFSAEVKFLIHRILDPNPKTRIQIQGIKKD 261 F + + S PP + L+ R + R + Sbjct: 808 FGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQL--H 865 Query: 262 PWF 264 + Sbjct: 866 RFL 868 >4EQM-A nrPDB Length = 294 Score = 221 bits (564), Expect = 4e-58, Method: Composition-based stats. Identities = 71/262 (27%), Positives = 119/262 (45%), Gaps = 12/262 (4%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 +Y++ +G G + V A +T VAIK + K + + +RE+ + H Sbjct: 11 ERYKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETLKRFEREVHNSSQLSH 70 Query: 69 PNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCK 128 NIV + +V Y+V+E++ G L + I G L + + Q++D + H H Sbjct: 71 QNIVSMIDVDEEDDCYYLVMEYIEGPTLSEYIESHGPLSVDTAINFTNQILDGIKHAHDM 130 Query: 129 GVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTC-GTPNYVAPEVLSGQGYD 187 + HRD+KP+N+L+D+N LK+ DFG++ E GT Y +PE G+ D Sbjct: 131 RIVHRDIKPQNILIDSNKTLKIFDFGIAKALSETSLTQTNHVLGTVQYFSPEQAKGEATD 190 Query: 188 GSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCP-------PWFSAEVKFL 240 DI+S G++L+ +L G PF+ + I + S P + + Sbjct: 191 -ECTDIYSIGIVLYEMLVGEPPFNGETAVSI--AIKHIQDSVPNVTTDVRKDIPQSLSNV 247 Query: 241 IHRILDPNPKTRI-QIQGIKKD 261 I R + + R IQ +K D Sbjct: 248 ILRATEKDKANRYKTIQEMKDD 269 >3PP0-A nrPDB Length = 338 Score = 221 bits (564), Expect = 4e-58, Method: Composition-based stats. Identities = 54/254 (21%), Positives = 113/254 (44%), Gaps = 13/254 (5%) Query: 14 GRTIGEGTFAKVKFARNTDTGDNV----AIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 + +G G F V G+NV AIK++ ++T K +I E +M V P Sbjct: 22 VKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKAN--KEILDEAYVMAGVGSP 79 Query: 70 NIVRLYEVLASPSKIYIVLEFVTGGELFDRIV-HKGRLEESESRKYFQQLVDAVAHCHCK 128 + RL + + + + +V + + G L D + ++GRL + + Q+ +++ Sbjct: 80 YVSRLLGICLTST-VQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDV 138 Query: 129 GVYHRDLKPENLLLDTNGNLKVSDFGLSALP--QEGVELLRTTCGTPNYVAPEVLSGQGY 186 + HRDL N+L+ + ++K++DFGL+ L E ++A E + + + Sbjct: 139 RLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRF 198 Query: 187 DGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAAE-FSCPPWFSAEVKFLIHRI 244 +D+WS GV ++ ++ G P+ + + E PP + +V ++ + Sbjct: 199 -THQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKC 257 Query: 245 LDPNPKTRIQIQGI 258 + + R + + + Sbjct: 258 WMIDSECRPRFREL 271 >1ZXE-A nrPDB Length = 303 Score = 221 bits (564), Expect = 4e-58, Method: Composition-based stats. Identities = 74/306 (24%), Positives = 139/306 (45%), Gaps = 47/306 (15%) Query: 5 MRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMK 64 +R +E +G+G F +V ARN AIK + + I E+ ++ Sbjct: 2 LRYASDFEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRH----TEEKLSTILSEVMLLA 57 Query: 65 IVRHPNIVRLYEVLAS-------------PSKIYIVLEFVTGGELFDRIVHKGRLEE--S 109 + H +VR Y S ++I +E+ L+D ++H L + Sbjct: 58 SLNHQYVVRYYAAWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYD-LIHSENLNQQRD 116 Query: 110 ESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLR-- 167 E + F+Q+++A+++ H +G+ HR+LKP N+ +D + N+K+ DFGL+ +++L+ Sbjct: 117 EYWRLFRQILEALSYIHSQGIIHRNLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLD 176 Query: 168 ------------TTCGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFS-ETD 214 + GT YVA EVL G G+ D++S G+I F ++ PFS + Sbjct: 177 SQNLPGSSDNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMI---YPFSTGME 233 Query: 215 LPGLYRKINAAEFSCPPWFSAE----VKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVP 270 + +K+ + PP F K +I ++D +P R + + ++P Sbjct: 234 RVNILKKLRSVSIEFPPDFDDNKMKVEKKIIRLLIDHDPNKRPGARTLLN-----SGWLP 288 Query: 271 IRAREE 276 ++ ++E Sbjct: 289 VKHQDE 294 >6DBN-A nrPDB Length = 316 Score = 221 bits (564), Expect = 4e-58, Method: Composition-based stats. Identities = 66/279 (23%), Positives = 120/279 (43%), Gaps = 37/279 (13%) Query: 12 EVGRTIGEGTFAKVKFARNT----DTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR 67 + R +GEG F KV+ R +TG+ VA+K + + + +K+EI I++ + Sbjct: 38 KRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESG--GNHIADLKKEIEILRNLY 95 Query: 68 HPNIVRLYEVLASP--SKIYIVLEFVTGGELFDRI-VHKGRLEESESRKYFQQLVDAVAH 124 H NIV+ + + I +++EF+ G L + + +K ++ + KY Q+ + + Sbjct: 96 HENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDY 155 Query: 125 CHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLR---TTCGTPNYVAPEVL 181 + HRDL N+L+++ +K+ DFGL+ + E + APE L Sbjct: 156 LGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECL 215 Query: 182 SGQGYDGSAADIWSCGVILFVILAGYLPFSETD--LPGLYRKI----------------- 222 + A+D+WS GV L +L + ++D L+ K+ Sbjct: 216 MQSKFY-IASDVWSFGVTLHELLT----YCDSDSSPMALFLKMIGPTHGQMTVTRLVNTL 270 Query: 223 -NAAEFSCPPWFSAEVKFLIHRILDPNPKTRIQIQGIKK 260 CPP EV L+ + + P R Q + + Sbjct: 271 KEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIE 309 >1U59-A nrPDB Length = 287 Score = 221 bits (563), Expect = 6e-58, Method: Composition-based stats. Identities = 65/248 (26%), Positives = 110/248 (44%), Gaps = 12/248 (4%) Query: 16 TIGEGTFAKVKFA--RNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVR 73 +G G F V+ R +VAIK++ + T + +++ RE IM + +P IVR Sbjct: 17 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGT--EKADTEEMMREAQIMHQLDNPYIVR 74 Query: 74 LYEVLASPSKIYIVLEFVTGGELFDRIV-HKGRLEESESRKYFQQLVDAVAHCHCKGVYH 132 L V + + + +V+E GG L +V + + S + Q+ + + K H Sbjct: 75 LIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVH 133 Query: 133 RDLKPENLLLDTNGNLKVSDFGLSALP--QEGVELLRTTCGTP-NYVAPEVLSGQGYDGS 189 RDL N+LL K+SDFGLS + R+ P + APE ++ + + S Sbjct: 134 RDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKF-SS 192 Query: 190 AADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAAE-FSCPPWFSAEVKFLIHRILDP 247 +D+WS GV ++ L+ G P+ + P + I + CPP E+ L+ Sbjct: 193 RSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIY 252 Query: 248 NPKTRIQI 255 + R Sbjct: 253 KWEDRPDF 260 >6E4F-A nrPDB Length = 290 Score = 221 bits (563), Expect = 6e-58, Method: Composition-based stats. Identities = 60/254 (23%), Positives = 110/254 (43%), Gaps = 10/254 (3%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 + +G G F VK+ + D VAIK++ + ++ + D+ E +M + H Sbjct: 32 DLTFLKELGTGQFGVVKYGKWRGQYD-VAIKMIKEGSMSE----DEFIEEAKVMMNLSHE 86 Query: 70 NIVRLYEVLASPSKIYIVLEFVTGGELFDRIVH-KGRLEESESRKYFQQLVDAVAHCHCK 128 +V+LY V I+I+ E++ G L + + + R + + + + + +A+ + K Sbjct: 87 KLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESK 146 Query: 129 GVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTP-NYVAPEVLSGQGYD 187 HRDL N L++ G +KVSDFGLS + P + PEVL + Sbjct: 147 QFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKF- 205 Query: 188 GSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAAEFSCPPWF-SAEVKFLIHRIL 245 S +DIW+ GV+++ I + G +P+ I P S +V +++ Sbjct: 206 SSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCW 265 Query: 246 DPNPKTRIQIQGIK 259 R + + Sbjct: 266 HEKADERPTFKILL 279 >3VN9-A nrPDB Length = 340 Score = 221 bits (563), Expect = 6e-58, Method: Composition-based stats. Identities = 68/271 (25%), Positives = 119/271 (43%), Gaps = 12/271 (4%) Query: 7 RVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIV 66 + E +G G + V+ R+ +G +A+K + + + + + +IS M+ V Sbjct: 49 KADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDIS-MRTV 107 Query: 67 RHPNIVRLYEVLASPSKIYIVLEFVTG--GELFDRIVHKGR-LEESESRKYFQQLVDAVA 123 P V Y L ++I +E + + + +++ KG+ + E K +V A+ Sbjct: 108 DCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALE 167 Query: 124 HCHCK-GVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLS 182 H H K V HRD+KP N+L++ G +K+ DFG+S + V G Y+APE ++ Sbjct: 168 HLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAK-TIDAGCKPYMAPERIN 226 Query: 183 ---GQGYDGSAADIWSCGVILFVILAGYLPF--SETDLPGLYRKINAAEFSCP-PWFSAE 236 Q +DIWS G+ + + P+ T L + + P FSAE Sbjct: 227 PELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAE 286 Query: 237 VKFLIHRILDPNPKTRIQIQGIKKDPWFRLN 267 + L N K R + + P+F L+ Sbjct: 287 FVDFTSQCLKKNSKERPTYPELMQHPFFTLH 317 >3PLS-A nrPDB Length = 298 Score = 220 bits (561), Expect = 8e-58, Method: Composition-based stats. Identities = 58/253 (22%), Positives = 110/253 (43%), Gaps = 14/253 (5%) Query: 15 RTIGEGTFAKVKFARNTDTGD---NVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNI 71 R IG+G F V D AIK +++ I + + V+ RE +M+ + HPN+ Sbjct: 27 RVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSR--ITEMQQVEAFLREGLLMRGLNHPNV 84 Query: 72 VRLYEVLASPSKI-YIVLEFVTGGELFDRIVHKGR-LEESESRKYFQQLVDAVAHCHCKG 129 + L ++ P + +++L ++ G+L I R + + Q+ + + + Sbjct: 85 LALIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLAEQK 144 Query: 130 VYHRDLKPENLLLDTNGNLKVSDFGLSALPQE----GVELLRTTCGTPNYVAPEVLSGQG 185 HRDL N +LD + +KV+DFGL+ + V+ R + A E L Sbjct: 145 FVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWTALESLQTYR 204 Query: 186 YDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAA-EFSCPPWFSAEVKFLIHR 243 + + +D+WS GV+L+ +L G P+ D L + P + + ++ + Sbjct: 205 F-TTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSLYQVMQQ 263 Query: 244 ILDPNPKTRIQIQ 256 + +P R + Sbjct: 264 CWEADPAVRPTFR 276 >5GRN-A nrPDB Length = 356 Score = 220 bits (561), Expect = 9e-58, Method: Composition-based stats. Identities = 66/330 (20%), Positives = 131/330 (39%), Gaps = 51/330 (15%) Query: 2 TKKMRRVGKYE-------VGRTIGEGTFAKVKFARNTDTGD-----NVAIKIMAKSTILK 49 ++ ++E +GR +G G F KV VA+K++ + Sbjct: 32 PMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSS 91 Query: 50 NRMVDQIKREISIMKIVR-HPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHK----- 103 + + E+ IM + H NIV L IYI+ E+ G+L + + Sbjct: 92 EKQ--ALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFL 149 Query: 104 ---------------------GRLEESESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLL 142 L + + Q+ + K HRDL N+LL Sbjct: 150 SHKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLL 209 Query: 143 DTNGNLKVSDFGLSA-LPQEGVELLRTTCGTP-NYVAPEVLSGQGYDGSAADIWSCGVIL 200 +K+ DFGL+ + + + + + P ++APE + Y + +D+WS G++L Sbjct: 210 AQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLY-TTLSDVWSYGILL 268 Query: 201 FVILA-GYLPFSETDLPGL-YRKINAA-EFSCPPWFSAEVKFLIHRILDPNPKTRIQIQG 257 + I + G P+ + Y KI + + P ++EV ++ + + P+ R Sbjct: 269 WEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYH 328 Query: 258 IKKDPWFRLNYVPIRAREE-EEVNLDDIRA 286 + + N +P + ++ E+++LD +++ Sbjct: 329 LSE---IVENLLPGQYKKSYEKIHLDFLKS 355 >4E20-A nrPDB Length = 290 Score = 220 bits (561), Expect = 1e-57, Method: Composition-based stats. Identities = 68/275 (24%), Positives = 115/275 (41%), Gaps = 30/275 (10%) Query: 10 KY-EVGRTIGEGTFAKVKFA----RNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMK 64 +Y + R +GEG F KV N TG+ VA+K + + + R +REI I++ Sbjct: 8 RYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSG--WQREIEILR 65 Query: 65 IVRHPNIVRLYEVLASPSK--IYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAV 122 + H +IV+ + + +V+E+V G L D + + ++ + QQ+ + + Sbjct: 66 TLYHEHIVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYLPRHC-VGLAQLLLFAQQICEGM 124 Query: 123 AHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLR---TTCGTPNYVAPE 179 A+ H + HR L N+LLD + +K+ DFGL+ EG E R + APE Sbjct: 125 AYLHAQHYIHRALAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPE 184 Query: 180 VLSGQGYDGSAADIWSCGVILFVILA----GYLPF-----------SETDLPGLYRKINA 224 L + A+D+WS GV L+ +L P + + L + Sbjct: 185 CLKECKFY-YASDVWSFGVTLYELLTYCDSNQSPHTKFTELIGHTQGQMTVLRLTELLER 243 Query: 225 AE-FSCPPWFSAEVKFLIHRILDPNPKTRIQIQGI 258 E P E+ L+ + R Q + Sbjct: 244 GERLPRPDRCPCEIYHLMKNCWETEASFRPTFQNL 278 >5HLW-A nrPDB Length = 299 Score = 220 bits (560), Expect = 1e-57, Method: Composition-based stats. Identities = 57/255 (22%), Positives = 105/255 (41%), Gaps = 14/255 (5%) Query: 15 RTIGEGTFAKVKFARNTDT---GDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNI 71 IG G F V D + A+K + + T + V Q E IMK HPN+ Sbjct: 26 EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGE--VSQFLTEGIIMKDFSHPNV 83 Query: 72 VRLYEVL-ASPSKIYIVLEFVTGGELFDRIVHK-GRLEESESRKYFQQLVDAVAHCHCKG 129 + L + S +VL ++ G+L + I ++ + + Q+ + + K Sbjct: 84 LSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKK 143 Query: 130 VYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELL---RTTCGTP-NYVAPEVLSGQG 185 HRDL N +LD +KV+DFGL+ + +T P ++A E L Q Sbjct: 144 FVHRDLAARNCMLDEKFTVKVADFGLARDMHDKEYYSVHNKTGAKLPVKWMALESLQTQK 203 Query: 186 YDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAA-EFSCPPWFSAEVKFLIHR 243 + + +D+WS GV+L+ ++ G P+ + + + + P + + ++ + Sbjct: 204 F-TTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLK 262 Query: 244 ILDPNPKTRIQIQGI 258 P + R + Sbjct: 263 CWHPKAEMRPSFSEL 277 >4XI2-A nrPDB Length = 446 Score = 220 bits (560), Expect = 1e-57, Method: Composition-based stats. Identities = 60/254 (23%), Positives = 109/254 (42%), Gaps = 10/254 (3%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 + +G G F VK+ + D VAIK++ + ++ + D+ E +M + H Sbjct: 188 DLTFLKELGTGQFGVVKYGKWRGQYD-VAIKMIREGSMSE----DEFIEEAKVMMNLSHE 242 Query: 70 NIVRLYEVLASPSKIYIVLEFVTGGELFDRIVH-KGRLEESESRKYFQQLVDAVAHCHCK 128 +V+LY V I+I+ E++ G L + + + R + + + + + +A+ + K Sbjct: 243 KLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESK 302 Query: 129 GVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTP-NYVAPEVLSGQGYD 187 HRDL N L++ G +KVSDFGLS + P + PEVL + Sbjct: 303 QFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKF- 361 Query: 188 GSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAAEFSCPPWF-SAEVKFLIHRIL 245 S +DIW+ GV+++ I + G +P+ I P S V +++ Sbjct: 362 SSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASERVYTIMYSCW 421 Query: 246 DPNPKTRIQIQGIK 259 R + + Sbjct: 422 HEKADERPSFKILL 435 >1TKI-A nrPDB Length = 321 Score = 219 bits (559), Expect = 1e-57, Method: Composition-based stats. Identities = 73/270 (27%), Positives = 124/270 (45%), Gaps = 13/270 (4%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 KY + +G G F V T + K + +K +K+EISI+ I RH Sbjct: 5 EKYMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVK----VKGTDQVLVKKEISILNIARH 60 Query: 69 PNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKG-RLEESESRKYFQQLVDAVAHCHC 127 NI+ L+E S ++ ++ EF++G ++F+RI L E E Y Q+ +A+ H Sbjct: 61 RNILHLHESFESMEELVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCEALQFLHS 120 Query: 128 KGVYHRDLKPENLLLDT--NGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQG 185 + H D++PEN++ T + +K+ +FG + + G + R P Y APEV Sbjct: 121 HNIGHFDIRPENIIYQTRRSSTIKIIEFGQARQLKPG-DNFRLLFTAPEYYAPEV-HQHD 178 Query: 186 YDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPP----WFSAEVKFLI 241 +A D+WS G +++V+L+G PF + I AE++ S E + Sbjct: 179 VVSTATDMWSLGTLVYVLLSGINPFLAETNQQIIENIMNAEYTFDEEAFKEISIEAMDFV 238 Query: 242 HRILDPNPKTRIQIQGIKKDPWFRLNYVPI 271 R+L K+R+ + PW + + Sbjct: 239 DRLLVKERKSRMTASEALQHPWLKQKIERV 268 >3ZBF-A nrPDB Length = 322 Score = 219 bits (559), Expect = 2e-57, Method: Composition-based stats. Identities = 55/265 (20%), Positives = 101/265 (38%), Gaps = 25/265 (9%) Query: 17 IGEGTFAKVKFARNTD-----TGD-NVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 +G G F +V D +G+ VA+K + K + + ++ + +E +M HPN Sbjct: 41 LGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKI--EFLKEAHLMSKFNHPN 98 Query: 71 IVRLYEVLASPSKIYIVLEFVTGGELFDRIVHK-------GRLEESESRKYFQQLVDAVA 123 I++ V YI+LE + GG+L + L + + Sbjct: 99 ILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCV 158 Query: 124 HCHCKGVYHRDLKPENLLLDTNGN-----LKVSDFGLSALPQEGVELLRTTCG--TPNYV 176 + HRDL N L+ +K+ DFGL+ + + G ++ Sbjct: 159 YLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWM 218 Query: 177 APEVLSGQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINA-AEFSCPPWFS 234 APE L G + +D+WS G++++ IL G+ P+ + + P Sbjct: 219 APESLMD-GIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCP 277 Query: 235 AEVKFLIHRILDPNPKTRIQIQGIK 259 ++ L+ + P R I+ Sbjct: 278 DDLWNLMTQCWAQEPDQRPTFHRIQ 302 >4PWN-A nrPDB Length = 274 Score = 219 bits (559), Expect = 2e-57, Method: Composition-based stats. Identities = 64/266 (24%), Positives = 124/266 (46%), Gaps = 16/266 (6%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 K+++ IG G+F V +T+T VA + + K+ + K E ++K ++HP Sbjct: 13 KFDI--EIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSE-RQRFKEEAEMLKGLQHP 69 Query: 70 NIVRLYEVLAS----PSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHC 125 NIVR Y+ S I +V E +T G L + ++ R + +Q++ + Sbjct: 70 NIVRFYDSWESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGLQFL 129 Query: 126 HCK--GVYHRDLKPENLLLD-TNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLS 182 H + + HRDLK +N+ + G++K+ D GL+ L + ++ GTP ++APE+ Sbjct: 130 HTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLEKR-ASFAKSVIGTPEFMAPEMYE 188 Query: 183 GQGYDGSAADIWSCGVILFVILAGYLPFSE-TDLPGLYRKINAAEFS--CPPWFSAEVKF 239 + + D+++ G+ + + P+SE + +YR++ + EVK Sbjct: 189 EK--YDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPASFDKVAIPEVKE 246 Query: 240 LIHRILDPNPKTRIQIQGIKKDPWFR 265 +I + N R I+ + +F+ Sbjct: 247 IIEGCIRQNKDERYSIKDLLNHAFFQ 272 >1AD5-A nrPDB Length = 438 Score = 219 bits (558), Expect = 2e-57, Method: Composition-based stats. Identities = 57/252 (22%), Positives = 113/252 (44%), Gaps = 20/252 (7%) Query: 12 EVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNI 71 ++ + +G G F +V A + VA+K M ++ V+ E ++MK ++H + Sbjct: 185 KLEKKLGAGQFGEVWMATY-NKHTKVAVKTMKPGSMS----VEAFLAEANVMKTLQHDKL 239 Query: 72 VRLYEVLASPSKIYIVLEFVTGGELFDRIVHKG--RLEESESRKYFQQLVDAVAHCHCKG 129 V+L+ V+ + IYI+ EF+ G L D + + + + Q+ + +A + Sbjct: 240 VKLHAVV-TKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRN 298 Query: 130 VYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGS 189 HRDL+ N+L+ + K++DFGL+ + + APE ++ + Sbjct: 299 YIHRDLRAANILVSASLVCKIADFGLARV---------GAKFPIKWTAPEAINFGSF-TI 348 Query: 190 AADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAA-EFSCPPWFSAEVKFLIHRILDP 247 +D+WS G++L I+ G +P+ P + R + P E+ ++ R Sbjct: 349 KSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKN 408 Query: 248 NPKTRIQIQGIK 259 P+ R + I+ Sbjct: 409 RPEERPTFEYIQ 420 >3LZB-A nrPDB Length = 327 Score = 218 bits (557), Expect = 3e-57, Method: Composition-based stats. Identities = 53/258 (20%), Positives = 114/258 (44%), Gaps = 13/258 (5%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNV----AIKIMAKSTILKNRMVDQIKREISIMKI 65 +++ + +G G F V G+ V AIK + ++T K +I E +M Sbjct: 16 EFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKAN--KEILDEAYVMAS 73 Query: 66 VRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIV-HKGRLEESESRKYFQQLVDAVAH 124 V +P++ RL + + + + ++ + + G L D + HK + + Q+ + + Sbjct: 74 VDNPHVCRLLGICLTST-VQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNY 132 Query: 125 CHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCG--TPNYVAPEVLS 182 + + HRDL N+L+ T ++K++DFGL+ L + G ++A E + Sbjct: 133 LEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESIL 192 Query: 183 GQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAAE-FSCPPWFSAEVKFL 240 + Y +D+WS GV ++ ++ G P+ + + E PP + +V + Sbjct: 193 HRIY-THQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMI 251 Query: 241 IHRILDPNPKTRIQIQGI 258 + + + +R + + + Sbjct: 252 MRKCWMIDADSRPKFREL 269 >3FME-A nrPDB Length = 290 Score = 218 bits (557), Expect = 3e-57, Method: Composition-based stats. Identities = 68/271 (25%), Positives = 119/271 (43%), Gaps = 12/271 (4%) Query: 7 RVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIV 66 + E +G G + V+ R+ +G +A+K + + + + + +IS M+ V Sbjct: 5 KADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDIS-MRTV 63 Query: 67 RHPNIVRLYEVLASPSKIYIVLEFVTG--GELFDRIVHKGR-LEESESRKYFQQLVDAVA 123 P V Y L ++I +E + + + +++ KG+ + E K +V A+ Sbjct: 64 DCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALE 123 Query: 124 HCHCK-GVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLS 182 H H K V HRD+KP N+L++ G +K+ DFG+S + V G Y+APE ++ Sbjct: 124 HLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDDVAK-DIDAGCKPYMAPERIN 182 Query: 183 ---GQGYDGSAADIWSCGVILFVILAGYLPF--SETDLPGLYRKINAAEFSCP-PWFSAE 236 Q +DIWS G+ + + P+ T L + + P FSAE Sbjct: 183 PELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAE 242 Query: 237 VKFLIHRILDPNPKTRIQIQGIKKDPWFRLN 267 + L N K R + + P+F L+ Sbjct: 243 FVDFTSQCLKKNSKERPTYPELMQHPFFTLH 273 >3I81-A nrPDB Length = 315 Score = 218 bits (557), Expect = 3e-57, Method: Composition-based stats. Identities = 57/269 (21%), Positives = 108/269 (40%), Gaps = 22/269 (8%) Query: 9 GKYEVGRTIGEGTFAKVKFARNT-----DTGDNVAIKIMAKSTILKNRMVDQIKREISIM 63 K + R +G+G+F V + VAIK + ++ ++ R+ + E S+M Sbjct: 18 EKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERI--EFLNEASVM 75 Query: 64 KIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGR----------LEESESRK 113 K ++VRL V++ +++E +T G+L + S+ + Sbjct: 76 KEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQ 135 Query: 114 YFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCG-- 171 ++ D +A+ + HRDL N ++ + +K+ DFG++ E + G Sbjct: 136 MAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLL 195 Query: 172 TPNYVAPEVLSGQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAAE-FSC 229 +++PE L G + +D+WS GV+L+ I P+ + R + Sbjct: 196 PVRWMSPESLKD-GVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDK 254 Query: 230 PPWFSAEVKFLIHRILDPNPKTRIQIQGI 258 P + L+ NPK R I Sbjct: 255 PDNCPDMLFELMRMCWQYNPKMRPSFLEI 283 >3C1X-A nrPDB Length = 373 Score = 218 bits (555), Expect = 5e-57, Method: Composition-based stats. Identities = 56/255 (21%), Positives = 102/255 (40%), Gaps = 14/255 (5%) Query: 15 RTIGEGTFAKVKFARNTDT---GDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNI 71 IG G F V D + A+K + + T + V Q E IMK HPN+ Sbjct: 95 EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGE--VSQFLTEGIIMKDFSHPNV 152 Query: 72 VRLYEVL-ASPSKIYIVLEFVTGGELFDRIVHK-GRLEESESRKYFQQLVDAVAHCHCKG 129 + L + S +VL ++ G+L + I ++ + + Q+ + K Sbjct: 153 LSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKFLASKK 212 Query: 130 VYHRDLKPENLLLDTNGNLKVSDFGLSALPQ----EGVELLRTTCGTPNYVAPEVLSGQG 185 HRDL N +LD +KV+DFGL+ + V ++A E L Q Sbjct: 213 FVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEFDSVHNKTGAKLPVKWMALESLQTQK 272 Query: 186 YDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAA-EFSCPPWFSAEVKFLIHR 243 + + +D+WS GV+L+ ++ G P+ + + + + P + + ++ + Sbjct: 273 F-TTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLK 331 Query: 244 ILDPNPKTRIQIQGI 258 P + R + Sbjct: 332 CWHPKAEMRPSFSEL 346 >5GNK-A nrPDB Length = 297 Score = 218 bits (555), Expect = 5e-57, Method: Composition-based stats. Identities = 53/258 (20%), Positives = 115/258 (44%), Gaps = 13/258 (5%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNV----AIKIMAKSTILKNRMVDQIKREISIMKI 65 +++ + +G G F V G+ V AIK + ++T K +I E +M Sbjct: 20 EFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKAN--KEILDEAYVMAS 77 Query: 66 VRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIV-HKGRLEESESRKYFQQLVDAVAH 124 V +P++ RL + + + + ++++ + G L D + HK + + Q+ + + Sbjct: 78 VDNPHVCRLLGICLTST-VQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNY 136 Query: 125 CHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCG--TPNYVAPEVLS 182 + + HRDL N+L+ T ++K++DFGL+ L + G ++A E + Sbjct: 137 LEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESIL 196 Query: 183 GQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAAE-FSCPPWFSAEVKFL 240 + Y +D+WS GV ++ ++ G P+ + + E PP + +V + Sbjct: 197 HRIY-THQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMI 255 Query: 241 IHRILDPNPKTRIQIQGI 258 + + + +R + + + Sbjct: 256 MVKCWMIDADSRPKFREL 273 >4YFF-A nrPDB Length = 311 Score = 217 bits (554), Expect = 7e-57, Method: Composition-based stats. Identities = 66/259 (25%), Positives = 116/259 (44%), Gaps = 9/259 (3%) Query: 7 RVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIV 66 ++ + E IG G+F KV R VAIK +T VD RE+SI+ + Sbjct: 40 QLSEIEFHEIIGSGSFGKVYKGRCR--NKIVAIKRYRANTYCSKSDVDMFCREVSILCQL 97 Query: 67 RHPNIVRLYEVLA-SPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQ-QLVDAVAH 124 HP +++ PS+ IV ++++GG LF + + R+ + +S+ + + + Sbjct: 98 NHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEY 157 Query: 125 CH--CKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQE-GVELLRTTCGTPNYVAPEVL 181 H + + HRDL N+LL +G+ V+DFG S Q + + G ++APEV Sbjct: 158 LHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVF 217 Query: 182 SGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFS--AEVKF 239 + AD++S + L+ IL G +PF+ + P +S + Sbjct: 218 TQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISS 277 Query: 240 LIHRILDPNPKTRIQIQGI 258 L+ R + P+ R + + Sbjct: 278 LLIRGWNACPEGRPEFSEV 296 >4HVI-A nrPDB Length = 314 Score = 217 bits (552), Expect = 1e-56, Method: Composition-based stats. Identities = 74/268 (27%), Positives = 124/268 (46%), Gaps = 30/268 (11%) Query: 17 IGEGTFAKVKFARNT----DTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIV 72 +G+G F V+ R +TG VA+K + S + R +REI I+K + IV Sbjct: 18 LGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRD---FQREIQILKALHSDFIV 74 Query: 73 RLYEVLASPSK--IYIVLEFVTGGELFDRI-VHKGRLEESESRKYFQQLVDAVAHCHCKG 129 + V P + + +V+E++ G L D + H+ RL+ S Y Q+ + + + Sbjct: 75 KYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRR 134 Query: 130 VYHRDLKPENLLLDTNGNLKVSDFGLSAL--PQEGVELLRTTCGTP-NYVAPEVLSGQGY 186 HRDL N+L+++ ++K++DFGL+ L + ++R +P + APE LS + Sbjct: 135 CVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIF 194 Query: 187 DGSAADIWSCGVILFVILA----GYLP---F-----SETDLPGLYRKINAA----EFSCP 230 +D+WS GV+L+ + P F SE D+P L R + P Sbjct: 195 -SRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGSERDVPALSRLLELLEEGQRLPAP 253 Query: 231 PWFSAEVKFLIHRILDPNPKTRIQIQGI 258 P AEV L+ P+P+ R + Sbjct: 254 PACPAEVHELMKLCWAPSPQDRPSFSAL 281 >3HMP-A nrPDB Length = 342 Score = 217 bits (552), Expect = 1e-56, Method: Composition-based stats. Identities = 72/278 (25%), Positives = 129/278 (46%), Gaps = 21/278 (7%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR-HP 69 Y + + IG G +KV N + AIK + N+ +D + EI+ + ++ H Sbjct: 58 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEA-DNQTLDSYRNEIAYLNKLQQHS 115 Query: 70 N-IVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCK 128 + I+RLY+ + IY+V+E +L + K ++ E + Y++ +++AV H Sbjct: 116 DKIIRLYDYEITDQYIYMVME-CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQH 174 Query: 129 GVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELL--RTTCGTPNYVAPEVLSGQG- 185 G+ H DLKP N L+ +G LK+ DFG++ Q + + GT NY+ PE + Sbjct: 175 GIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSS 233 Query: 186 ---------YDGSAADIWSCGVILFVILAGYLPFSE--TDLPGLYRKIN-AAEFSCPPWF 233 +D+WS G IL+ + G PF + + L+ I+ E P Sbjct: 234 SRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIP 293 Query: 234 SAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVPI 271 +++ ++ L +PK RI I + P+ ++ P+ Sbjct: 294 EKDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQTHPV 331 >3M42-A nrPDB Length = 299 Score = 217 bits (552), Expect = 1e-56, Method: Composition-based stats. Identities = 82/309 (26%), Positives = 139/309 (44%), Gaps = 57/309 (18%) Query: 3 KKMRRVGKYEV-GRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREIS 61 KK + Y+V + +G G KV N T + A+K++ + + +RE+ Sbjct: 11 KKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML--------QDCPKARREVE 62 Query: 62 IM-KIVRHPNIVRLYEVLAS----PSKIYIVLEFVTGGELFDRIVHKGR--LEESESRKY 114 + + + P+IVR+ +V + + IV+E + GGELF RI +G E E+ + Sbjct: 63 LHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEI 122 Query: 115 FQQLVDAVAHCHCKGVYHRDLKPENLLLDT---NGNLKVSDFGLSALPQEGVELLRTTCG 171 + + +A+ + H + HRD+KPENLL + N LK++DFG + Sbjct: 123 MKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKET------------ 170 Query: 172 TPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETD----LPGLYRKINAAEF 227 +G+ YD + D+WS GVI++++L GY PF PG+ +I ++ Sbjct: 171 ----------TGEKYD-KSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQY 219 Query: 228 SCP----PWFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYV-------PIRAREE 276 P S EVK LI +L P R+ I PW + R +E Sbjct: 220 EFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKE 279 Query: 277 EEVNLDDIR 285 ++ +D++ Sbjct: 280 DKERWEDVK 288 >5HI2-A nrPDB Length = 283 Score = 216 bits (551), Expect = 1e-56, Method: Composition-based stats. Identities = 57/262 (21%), Positives = 111/262 (42%), Gaps = 21/262 (8%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 G+ VG+ IG G+F V + VA+K++ + + K E+ +++ RH Sbjct: 20 GQITVGQRIGSGSFGTVYKGKWHGD---VAVKML------TPQQLQAFKNEVGVLRKTRH 70 Query: 69 PNIVRLYEVLASPSKIYIVLEFVTGGELFDRIV-HKGRLEESESRKYFQQLVDAVAHCHC 127 NI+ ++ ++ IV ++ G L+ + + + E + +Q + + H Sbjct: 71 VNILLFMG-YSTKPQLAIVTQWCEGSSLYHHLHASETKFEMKKLIDIARQTARGMDYLHA 129 Query: 128 KGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQE--GVELLRTTCGTPNYVAPEVLSGQG 185 K + HRDLK N+ L + +K+ DFGL+ + G G+ ++APEV+ Q Sbjct: 130 KSIIHRDLKSNNIFLHEDNTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQD 189 Query: 186 Y--DGSAADIWSCGVILFVILAGYLPFSETDL-PGLYRKINAAEFSCP-----PWFSAEV 237 +D+++ G++L+ ++ G LP+S + + + S + Sbjct: 190 SNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEMVGRGSLSPDLSKVRSNCPKRM 249 Query: 238 KFLIHRILDPNPKTRIQIQGIK 259 K L+ L R I Sbjct: 250 KRLMAECLKKKRDERPSFPRIL 271 >2W1I-A nrPDB Length = 326 Score = 216 bits (550), Expect = 2e-56, Method: Composition-based stats. Identities = 65/274 (23%), Positives = 120/274 (43%), Gaps = 31/274 (11%) Query: 12 EVGRTIGEGTFAKVKFARNT----DTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR 67 + + +G+G F V+ R +TG+ VA+K + ST + +REI I+K ++ Sbjct: 44 KFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHST---EEHLRDFEREIEILKSLQ 100 Query: 68 HPNIVRLYEVLASPSK--IYIVLEFVTGGELFDRIV-HKGRLEESESRKYFQQLVDAVAH 124 H NIV+ V S + + +++E++ G L D + HK R++ + +Y Q+ + + Sbjct: 101 HDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEY 160 Query: 125 CHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTT---CGTPNYVAPEVL 181 K HRDL N+L++ +K+ DFGL+ + + E + + APE L Sbjct: 161 LGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESL 220 Query: 182 SGQGYDGSAADIWSCGVILFVILA-----GYLP-----FSETDLPG---LYRKI----NA 224 + + A+D+WS GV+L+ + P D G ++ I N Sbjct: 221 TESKF-SVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNN 279 Query: 225 AEFSCPPWFSAEVKFLIHRILDPNPKTRIQIQGI 258 P E+ ++ + N R + + Sbjct: 280 GRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDL 313 >3N9X-A nrPDB Length = 432 Score = 216 bits (550), Expect = 2e-56, Method: Composition-based stats. Identities = 81/374 (21%), Positives = 129/374 (34%), Gaps = 92/374 (24%) Query: 3 KKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISI 62 K + Y + IG G++ V A + +T NVAIK + + +I REI+I Sbjct: 20 KNVHVPDNYIIKHLIGRGSYGYVYLAYDKNTEKNVAIKKVNR-MFEDLIDCKRILREITI 78 Query: 63 MKIVRHPNIVRLYEVLASPS-----KIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQ 117 + ++ I+RLY+++ ++YIVLE +L L E + Sbjct: 79 LNRLKSDYIIRLYDLIIPDDLLKFDELYIVLEIAD-SDLKKLFKTPIFLTEEHIKTILYN 137 Query: 118 LVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVE------------- 164 L+ H G+ HRDLKP N LL+ + ++KV DFGL+ + Sbjct: 138 LLLGENFIHESGIIHRDLKPANCLLNQDCSVKVCDFGLARTINSEKDTNIVNDLEENEEP 197 Query: 165 ---------LLRTTCGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVIL----------- 204 L + T Y APE++ Q + DIWS G I +L Sbjct: 198 GPHNKNLKKQLTSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAELLNMLQSHINDPT 257 Query: 205 AGYLPFSET-----------------------------------------DLPGLYRKIN 223 + F + + P + + I Sbjct: 258 NRFPLFPGSSCFPLSPDRNSKKVHEKSNRDQLNIIFNIIGTPTEDDLKNINKPEVIKYIK 317 Query: 224 AAEFSCP-------PWFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREE 276 P P S + L+ +L NP RI I P+ + +R ++ Sbjct: 318 LFPHRKPINLKQKYPSISDDGINLLESMLKFNPNKRITIDQALDHPYLKD----VRKKKL 373 Query: 277 EEVNLDDIRAVFDG 290 E + I FD Sbjct: 374 ENFSTKKIILPFDD 387 >3IO7-A nrPDB Length = 313 Score = 216 bits (550), Expect = 2e-56, Method: Composition-based stats. Identities = 69/285 (24%), Positives = 125/285 (43%), Gaps = 33/285 (11%) Query: 1 MTKKMRRVGKYEVGRTIGEGTFAKVKFARNT----DTGDNVAIKIMAKSTILKNRMVDQI 56 MT+ R K+ + +G+G F V+ R +TG+ VA+K + ST + Sbjct: 22 MTQFEERHLKF--LQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHST---EEHLRDF 76 Query: 57 KREISIMKIVRHPNIVRLYEVLASPSK--IYIVLEFVTGGELFDRIV-HKGRLEESESRK 113 +REI I+K ++H NIV+ V S + + +++E++ G L D + HK R++ + + Sbjct: 77 EREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQ 136 Query: 114 YFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTT---C 170 Y Q+ + + K HRDL N+L++ +K+ DFGL+ + + E + Sbjct: 137 YTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGE 196 Query: 171 GTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILA-----GYLP-----FSETDLPG--- 217 + APE L+ + A+D+WS GV+L+ + P D G Sbjct: 197 SPIFWYAPESLTESKF-SVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMI 255 Query: 218 LYRKI----NAAEFSCPPWFSAEVKFLIHRILDPNPKTRIQIQGI 258 ++ I N P E+ ++ + N R + + Sbjct: 256 VFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDL 300 >5U6C-A nrPDB Length = 315 Score = 215 bits (549), Expect = 2e-56, Method: Composition-based stats. Identities = 57/262 (21%), Positives = 103/262 (39%), Gaps = 20/262 (7%) Query: 13 VGRTIGEGTFAKVKFARNTD---TGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 +G+ +GEG F V T VA+K M + R +++ E + MK HP Sbjct: 40 LGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQ-REIEEFLSEAACMKDFSHP 98 Query: 70 NIVRLYEVLASP-----SKIYIVLEFVTGGELFDRIVH------KGRLEESESRKYFQQL 118 N++RL V K ++L F+ G+L +++ + K+ + Sbjct: 99 NVMRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDI 158 Query: 119 VDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCG--TPNYV 176 + + + HRDL N +L + + V+DFGLS G + ++ Sbjct: 159 ALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWI 218 Query: 177 APEVLSGQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAA-EFSCPPWFS 234 A E L+ + Y S +D+W+ GV ++ I G P+ +Y + P Sbjct: 219 AIESLADRVY-TSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCL 277 Query: 235 AEVKFLIHRILDPNPKTRIQIQ 256 E+ +++ +P R Sbjct: 278 DELYEIMYSCWRTDPLDRPTFS 299 >5HVK-A nrPDB Length = 315 Score = 215 bits (549), Expect = 2e-56, Method: Composition-based stats. Identities = 61/274 (22%), Positives = 118/274 (43%), Gaps = 32/274 (11%) Query: 14 GRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVR 73 G +G+G F + + +TG+ + +K + + +E+ +M+ + HPN+++ Sbjct: 19 GEVLGKGCFGQAIKVTHRETGEVMVMKELIR---FDEETQRTFLKEVKVMRCLEHPNVLK 75 Query: 74 LYEVLASPSKIYIVLEFVTGGELFDRIVH-KGRLEESESRKYFQQLVDAVAHCHCKGVYH 132 VL ++ + E++ GG L I + S+ + + + +A+ H + H Sbjct: 76 FIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIH 135 Query: 133 RDLKPENLLLDTNGNLKVSDFGLSALP--------------QEGVELLRTTCGTPNYVAP 178 R+L N L+ N N+ V+DFGL+ L + + T G P ++AP Sbjct: 136 RNLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAP 195 Query: 179 EVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAA-------EFSCPP 231 E+++G+ YD D++S G++L I+ G + D L R ++ + CPP Sbjct: 196 EMINGRSYD-EKVDVFSFGIVLCEII-GRV---NADPDYLPRTMDFGLNVRGFLDRYCPP 250 Query: 232 WFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFR 265 + R D +P+ R + W Sbjct: 251 NCPPSFFPITVRCCDLDPEKRPSFVK-LEH-WLE 282 >5HIE-A nrPDB Length = 302 Score = 215 bits (548), Expect = 3e-56, Method: Composition-based stats. Identities = 57/262 (21%), Positives = 112/262 (42%), Gaps = 21/262 (8%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 G+ VG+ IG G+F V + VA+K++ + + K E+ +++ RH Sbjct: 36 GQITVGQRIGSGSFGTVYKGKWHGD---VAVKML------TPQQLQAFKNEVGVLRKTRH 86 Query: 69 PNIVRLYEVLASPSKIYIVLEFVTGGELFDRI-VHKGRLEESESRKYFQQLVDAVAHCHC 127 NI+ ++ ++ IV ++ G L+ + + + + E + +Q + + H Sbjct: 87 VNILLFMG-YSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHA 145 Query: 128 KGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQE--GVELLRTTCGTPNYVAPEVLSGQG 185 K + HRDLK N+ L + +K+ DFGL+ + G G+ ++APEV+ Q Sbjct: 146 KSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQD 205 Query: 186 Y--DGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPP------WFSAEV 237 +D+++ G++L+ ++ G LP+S + + + P + Sbjct: 206 KNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAM 265 Query: 238 KFLIHRILDPNPKTRIQIQGIK 259 K L+ L R I Sbjct: 266 KRLMAECLKKKRDERPLFPQIL 287 >5O0Y-A nrPDB Length = 579 Score = 215 bits (547), Expect = 4e-56, Method: Composition-based stats. Identities = 76/272 (27%), Positives = 114/272 (41%), Gaps = 26/272 (9%) Query: 22 FAKVKFARNTDTGDNVAIKI--MAK--STILKNRMVDQIKREISIMKIVRHPNIVRLYEV 77 F++V A + VA+KI + K K RE I K + HP IV+LY+ Sbjct: 297 FSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDY 356 Query: 78 LA-SPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHC--KGVYHRD 134 + VLE+ G +L + + E E+R Q+V+A+ + + + H D Sbjct: 357 FSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYD 416 Query: 135 LKPENLLL---DTNGNLKVSDFGLSALPQ-------EGVELLRTTCGTPNYVAPEVL--- 181 LKP N+LL G +K++DFGLS + +G+EL GT Y+ PE Sbjct: 417 LKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVG 476 Query: 182 SGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPG------LYRKINAAEFSCPPWFSA 235 + D+WS GVI + L G PF K +F P + Sbjct: 477 KEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTP 536 Query: 236 EVKFLIHRILDPNPKTRIQIQGIKKDPWFRLN 267 E K I R L + RI +Q + DP+ + Sbjct: 537 EAKAFIRRCLAYRKEDRIDVQQLACDPYLLPH 568 >5KKR-C nrPDB Length = 395 Score = 215 bits (547), Expect = 4e-56, Method: Composition-based stats. Identities = 67/302 (22%), Positives = 119/302 (39%), Gaps = 50/302 (16%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 +E +G G V + +G +A K++ +K + +QI RE+ ++ Sbjct: 68 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE--IKPAIRNQIIRELQVLHECNS 125 Query: 69 PNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHC-HC 127 P IV Y S +I I +E + GG L + GR+ E K ++ + + Sbjct: 126 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREK 185 Query: 128 KGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYD 187 + HRD+KP N+L+++ G +K+ DFG+S + + + GT +Y++PE L G Y Sbjct: 186 HKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS--MANSFVGTRSYMSPERLQGTHY- 242 Query: 188 GSAADIWSCGVILFVILAGYLPFSETDLPGL----------------------------- 218 +DIWS G+ L + G P D L Sbjct: 243 SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY 302 Query: 219 ----------YRKINAAEFSCPPW-----FSAEVKFLIHRILDPNPKTRIQIQGIKKDPW 263 + ++ PP FS E + +++ L NP R ++ + + Sbjct: 303 GMDSRPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF 362 Query: 264 FR 265 + Sbjct: 363 IK 364 >5AP3-A nrPDB Length = 313 Score = 214 bits (545), Expect = 7e-56, Method: Composition-based stats. Identities = 72/278 (25%), Positives = 129/278 (46%), Gaps = 21/278 (7%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR-HP 69 Y + + IG G +KV N + AIK + N+ +D + EI+ + ++ H Sbjct: 30 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEA-DNQTLDSYRNEIAYLNKLQQHS 87 Query: 70 N-IVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCK 128 + I+RLY+ + IY+V+E +L + K ++ E + Y++ +++AV H Sbjct: 88 DKIIRLYDYEITDQYIYMVME-CGNIDLNGWLKKKKSIDPWERKSYWKNMLEAVHTIHQH 146 Query: 129 GVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELL--RTTCGTPNYVAPEVLSGQG- 185 G+ H DLKP N L+ +G LK+ DFG++ Q + + GT NY+ PE + Sbjct: 147 GIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSS 205 Query: 186 ---------YDGSAADIWSCGVILFVILAGYLPFSE--TDLPGLYRKIN-AAEFSCPPWF 233 +D+WS G IL+ + G PF + + L+ I+ E P Sbjct: 206 SRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIP 265 Query: 234 SAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVPI 271 +++ ++ L +PK RI I + P+ ++ P+ Sbjct: 266 EKDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQTHPV 303 >2ZMD-A nrPDB Length = 390 Score = 213 bits (544), Expect = 8e-56, Method: Composition-based stats. Identities = 71/278 (25%), Positives = 128/278 (46%), Gaps = 21/278 (7%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR-HP 69 Y + + IG G +KV N + AIK + N+ +D + EI+ + ++ H Sbjct: 58 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEA-DNQTLDSYRNEIAYLNKLQQHS 115 Query: 70 N-IVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCK 128 + I+RLY+ + IY+V+E +L + K ++ E + Y++ +++AV H Sbjct: 116 DKIIRLYDYEITDQYIYMVME-CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQH 174 Query: 129 GVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELL--RTTCGTPNYVAPEVLSGQG- 185 G+ H DLKP N L+ +G LK+ DFG++ Q + + G NY+ PE + Sbjct: 175 GIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGAVNYMPPEAIKDMSS 233 Query: 186 ---------YDGSAADIWSCGVILFVILAGYLPFSE--TDLPGLYRKIN-AAEFSCPPWF 233 +D+WS G IL+ + G PF + + L+ I+ E P Sbjct: 234 SRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIP 293 Query: 234 SAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVPI 271 +++ ++ L +PK RI I + P+ ++ P+ Sbjct: 294 EKDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQTHPV 331 >4LRM-A nrPDB Length = 334 Score = 213 bits (542), Expect = 2e-55, Method: Composition-based stats. Identities = 53/261 (20%), Positives = 114/261 (43%), Gaps = 16/261 (6%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNV----AIKIMAKSTILKNRMVDQIKREISIMKI 65 +++ + +G G F V G+ V AIK + ++T K +I E +M Sbjct: 20 EFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKAN--KEILDEAYVMAS 77 Query: 66 VRHP---NIVRLYEVLASPSKIYIVLEFVTGGELFDRIV-HKGRLEESESRKYFQQLVDA 121 V +P ++ RL + + + + ++ + + G L D + HK + + Q+ Sbjct: 78 VDNPGNPHVCRLLGICLTST-VQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKG 136 Query: 122 VAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCG--TPNYVAPE 179 + + + + HRDL N+L+ T ++K++DFGL+ L + G ++A E Sbjct: 137 MNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALE 196 Query: 180 VLSGQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAAE-FSCPPWFSAEV 237 + + Y +D+WS GV ++ ++ G P+ + + E PP + +V Sbjct: 197 SILHRIY-THQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDV 255 Query: 238 KFLIHRILDPNPKTRIQIQGI 258 ++ + + +R + + + Sbjct: 256 YMIMVKCWMIDADSRPKFREL 276 >3EQC-A nrPDB Length = 360 Score = 213 bits (542), Expect = 2e-55, Method: Composition-based stats. Identities = 67/302 (22%), Positives = 119/302 (39%), Gaps = 50/302 (16%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 +E +G G V + +G +A K++ +K + +QI RE+ ++ Sbjct: 33 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE--IKPAIRNQIIRELQVLHECNS 90 Query: 69 PNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHC-HC 127 P IV Y S +I I +E + GG L + GR+ E K ++ + + Sbjct: 91 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREK 150 Query: 128 KGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYD 187 + HRD+KP N+L+++ G +K+ DFG+S + + + GT +Y++PE L G Y Sbjct: 151 HKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS--MANSFVGTRSYMSPERLQGTHY- 207 Query: 188 GSAADIWSCGVILFVILAGYLPFSETDLPGL----------------------------- 218 +DIWS G+ L + G P D L Sbjct: 208 SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLNKF 267 Query: 219 ----------YRKINAAEFSCPPW-----FSAEVKFLIHRILDPNPKTRIQIQGIKKDPW 263 + ++ PP FS E + +++ L NP R ++ + + Sbjct: 268 GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF 327 Query: 264 FR 265 + Sbjct: 328 IK 329 >5Y86-A nrPDB Length = 588 Score = 212 bits (541), Expect = 2e-55, Method: Composition-based stats. Identities = 75/353 (21%), Positives = 129/353 (36%), Gaps = 79/353 (22%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 +YEV + IG+G+F +V + VA+K++ + R Q EI I++ ++ Sbjct: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRN----EKRFHRQAAEEIRILEHLKKQ 263 Query: 70 ------NIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKG--RLEESESRKYFQQLVDA 121 N++ + E + + + E ++ +L++ I RK+ Q ++ + Sbjct: 264 DKTGSMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQGFSVQLVRKFAQSILQS 322 Query: 122 VAHCHCKGVYHRDLKPENLLLDTNGN--LKVSDFGLSALPQEGVELLRTTCGTPNYVAPE 179 + H + H DLKPEN+LL +G KV DFG S + L T + Y APE Sbjct: 323 LDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF---EYQKLYTYIQSRFYRAPE 379 Query: 180 VLSGQGYDGSAADIWSCGVILFVILAGYLPFSETD---------------LPGLYRKINA 224 ++ G Y + DIWS G IL +L G F D P L + Sbjct: 380 IILGSRY-STPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKR 438 Query: 225 AEF-----SCPPWFSAEVK---------------------------------------FL 240 A++ P + S + Sbjct: 439 AKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEF 498 Query: 241 IHRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEVNLDDIRAVFDGIEG 293 + R L +P R+ + PW + VP ++V+ + +G Sbjct: 499 LKRCLHWDPSARLTPAQALRHPWISKS-VPRPLTTIDKVSGKRVVNPASAFQG 550 >3OMV-A nrPDB Length = 307 Score = 212 bits (541), Expect = 2e-55, Method: Composition-based stats. Identities = 54/254 (21%), Positives = 109/254 (42%), Gaps = 16/254 (6%) Query: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYE 76 IG G+F V + VA+KI+ K + E+++++ RH NI+ Sbjct: 44 IGSGSFGTVYKGKWHGD---VAVKIL-KVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMG 99 Query: 77 VLASPSKIYIVLEFVTGGELFDRI-VHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDL 135 + + IV ++ G L+ + V + + + + +Q + + H K + HRD+ Sbjct: 100 -YMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDM 158 Query: 136 KPENLLLDTNGNLKVSDFGLSALPQE--GVELLRTTCGTPNYVAPEVLSGQGYD--GSAA 191 K N+ L +K+ DFGL+ + G + + G+ ++APEV+ Q + + Sbjct: 159 KSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQS 218 Query: 192 DIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPP------WFSAEVKFLIHRIL 245 D++S G++L+ ++ G LP+S + + ++ P +K L+ + Sbjct: 219 DVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCV 278 Query: 246 DPNPKTRIQIQGIK 259 + R I Sbjct: 279 KKVKEERPLFPQIL 292 >5WNO-A nrPDB Length = 330 Score = 212 bits (540), Expect = 3e-55, Method: Composition-based stats. Identities = 67/308 (21%), Positives = 128/308 (41%), Gaps = 22/308 (7%) Query: 12 EVGRTIGEGTFAKVKFA-----RNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIV 66 ++ + +G G F V R + VAIK+ D++ E + M + Sbjct: 25 KLDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVF----QTDQSQTDEMLEEATNMFRL 80 Query: 67 RHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRI-VHKGRLEESESRKYFQQLVDAVAHC 125 RH N++++ + IV + G L + + +HK L E Y Q+ + + Sbjct: 81 RHDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGMQYL 140 Query: 126 HCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCG--TPNYVAPEVLSG 183 + V HRDL N+L+ +++++DFGLS + + + + G ++A E+ S Sbjct: 141 EKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIEIFSK 200 Query: 184 QGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAA-EFSCPPWFSAEVKFLI 241 Y A+D+W+ GV + I+ G P+ ++ + S PP S ++ + Sbjct: 201 HCY-THASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQPPNCSQDLYQEL 259 Query: 242 HRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEE-EVNLDDIRAVFDGIEGSYVAENV 300 R +PK+R I + + VP E +++ D+ A E + E + Sbjct: 260 LRCWMADPKSRPGF-EILYERFKEFCKVPQLFLENSNKISESDLSA-----EERFQTERI 313 Query: 301 ERNDEGPL 308 +G + Sbjct: 314 REMFDGNI 321 >3E3P-A nrPDB Length = 360 Score = 212 bits (539), Expect = 3e-55, Method: Composition-based stats. Identities = 80/346 (23%), Positives = 141/346 (40%), Gaps = 59/346 (17%) Query: 6 RRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKI 65 + + +++V R G+GTF V+ + TG +VAIK + + +N RE+ IM+ Sbjct: 20 KEMDRFQVERMAGQGTFGTVQLGKEKSTGMSVAIKKVIQDPRFRN-------RELQIMQD 72 Query: 66 V---RHPNIVRLYEVLASPSK-------IYIVLEFVT---GGELFDRIVHKGRLEESESR 112 + HPNIV+L + + + +V+E+V + + + Sbjct: 73 LAVLHHPNIVQLQSYFYTLGERDRRDIYLNVVMEYVPDTLHRCCRNYYRRQVAPPPILIK 132 Query: 113 KYFQQLVDAVAHCH--CKGVYHRDLKPENLLLDT-NGNLKVSDFGLSALPQEGVELLRTT 169 + QL+ ++ H V HRD+KP N+L++ +G LK+ DFG + + Sbjct: 133 VFLFQLIRSIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKLSPSEPNVAYI 192 Query: 170 CGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSC 229 C + Y APE++ G + +A DIWS G I ++ G F + G +I C Sbjct: 193 C-SRYYRAPELIFGNQHYTTAVDIWSVGCIFAEMMLGEPIFRGDNSAGQLHEIVRV-LGC 250 Query: 230 P-----------------------PW---FSA-------EVKFLIHRILDPNPKTRIQIQ 256 P PW FS E L+ +L P+ R++ Sbjct: 251 PSREVLRKLNPSHTDVDLYNSKGIPWSNVFSDHSLKDAKEAYDLLSALLQYLPEERMKPY 310 Query: 257 GIKKDPWFRLNYVP-IRAREEEEVNLDDIRAVFDGIEGSYVAENVE 301 P+F + P + +++ D R + + IE A+ + Sbjct: 311 EALCHPYFDELHDPATKLPNNKDLPEDLFRFLPNEIEVMSEAQKAK 356 >3ALO-A nrPDB Length = 327 Score = 212 bits (539), Expect = 4e-55, Method: Composition-based stats. Identities = 63/267 (23%), Positives = 117/267 (43%), Gaps = 24/267 (8%) Query: 16 TIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISI-MKIVRHPNIVRL 74 IG G + V + +G +A+K + + + + Q+ ++ + M+ P IV+ Sbjct: 29 EIGRGAYGSVNKMVHKPSGQIMAVKRIR--STVDEKEQKQLLMDLDVVMRSSDCPYIVQF 86 Query: 75 YEVLASPSKIYIVLEFVTG--GELFDRIVH--KGRLEESESRKYFQQLVDAVAHCHCK-G 129 Y L +I +E ++ + + + + E K V A+ H Sbjct: 87 YGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKENLK 146 Query: 130 VYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVL----SGQG 185 + HRD+KP N+LLD +GN+K+ DFG+S + + R G Y+APE + S QG Sbjct: 147 IIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRD-AGCRPYMAPERIDPSASRQG 205 Query: 186 YDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPP--------WFSAEV 237 YD +D+WS G+ L+ + G P+ + + ++ ++ PP FS Sbjct: 206 YD-VRSDVWSLGITLYELATGRFPYPKWNS--VFDQLTQVVKGDPPQLSNSEEREFSPSF 262 Query: 238 KFLIHRILDPNPKTRIQIQGIKKDPWF 264 ++ L + R + + + K P+ Sbjct: 263 INFVNLCLTKDESKRPKYKELLKHPFI 289 >3NIE-A nrPDB Length = 429 Score = 210 bits (536), Expect = 7e-55, Method: Composition-based stats. Identities = 79/379 (20%), Positives = 133/379 (35%), Gaps = 95/379 (25%) Query: 1 MTKKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREI 60 + K ++ YE+ IG G++ V A + + NVAIK + + +I REI Sbjct: 20 IIKNVKVPDNYEIKHLIGRGSYGYVYLAYDKNANKNVAIKKVNR-MFEDLIDCKRILREI 78 Query: 61 SIMKIVRHPNIVRLYEVLASPS-----KIYIVLEFVTGGELFDRIVHKGRLEESESRKYF 115 +I+ ++ I+RL++++ ++YIVLE +L L E + Sbjct: 79 TILNRLKSDYIIRLHDLIIPEDLLKFDELYIVLEIAD-SDLKKLFKTPIFLTEQHVKTIL 137 Query: 116 QQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVE----------- 164 L+ H G+ HRDLKP N LL+ + ++K+ DFGL+ + Sbjct: 138 YNLLLGEKFIHESGIIHRDLKPANCLLNQDCSVKICDFGLARTINSDKDIHIVNDLEEKE 197 Query: 165 --------------LLRTTCGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVIL------ 204 L + T Y APE++ Q ++ DIWS G I +L Sbjct: 198 ENEEPGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTGCIFAELLNMMKSH 257 Query: 205 -----AGYLPFSET---------DLPGLYRKINAAEFSC-------PPW----------- 232 + F + + ++ K N + + PP Sbjct: 258 INNPTNRFPLFPGSSCFPLSPDHNSKKVHEKSNRDQLNIIFNVIGTPPEEDLKCITKQEV 317 Query: 233 ---------------------FSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVPI 271 S E L+ +L N + RI I P+ + + Sbjct: 318 IKYIKLFPTRDGIDLSKKYSSISKEGIDLLESMLRFNAQKRITIDKALSHPYLKD----V 373 Query: 272 RAREEEEVNLDDIRAVFDG 290 R E + + I FD Sbjct: 374 RKENLENFSTEKIILPFDD 392 >4NEU-A nrPDB Length = 333 Score = 210 bits (536), Expect = 9e-55, Method: Composition-based stats. Identities = 65/298 (21%), Positives = 125/298 (41%), Gaps = 27/298 (9%) Query: 16 TIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLY 75 + G F KV + G + +K + K + + E +M +RH +V+L Sbjct: 31 ELDSGGFGKVSLCFHRTQGLMI-MKTVYKGPNC-IEHNEALLEEAKMMNRLRHSRVVKLL 88 Query: 76 EVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDL 135 V+ K +V+E++ G L + + S + ++++ + + H KGV H+DL Sbjct: 89 GVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHGKGVIHKDL 148 Query: 136 KPENLLLDTNGNLKVSDFGLSAL-------------PQEGVELLRTTCGTPNYVAPEVLS 182 KPEN+L+D + ++K++D GL++ +E + GT Y+APE L+ Sbjct: 149 KPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHLN 208 Query: 183 G-QGYDGSAADIWSCGVILFVILAGYLPFSE-TDLPGLYRKINAAEFS----CPPWFSAE 236 +D++S V+L+ I A P+ L I + + E Sbjct: 209 DVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGNRPDVDDITEYCPRE 268 Query: 237 VKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEVNLDDIRAVFDGIEGS 294 + L+ + NP+ R GI++ + P + EE +D++++ Sbjct: 269 IISLMKLCWEANPEARPTFPGIEE------KFRPFYLSQLEESVEEDVKSLKKEYSNE 320 >6FER-A nrPDB Length = 309 Score = 210 bits (535), Expect = 1e-54, Method: Composition-based stats. Identities = 52/285 (18%), Positives = 96/285 (33%), Gaps = 41/285 (14%) Query: 12 EVGRTIGEGTFAKVKFAR--------------NTDTGD--NVAIKIMAKSTILKNRMVDQ 55 +GEG F +V + VA+K++ R + Sbjct: 12 TFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNAR--ND 69 Query: 56 IKREISIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGR---------- 105 +EI IM ++ PNI+ L V + + ++ E++ G+L + Sbjct: 70 FLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPNSSSSDVRT 129 Query: 106 LEESESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVEL 165 + + + Q+ + + HRDL N L+ N +K++DFG+S G Sbjct: 130 VSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYY 189 Query: 166 L--RTTCGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILA--GYLPFSETDLPGLYRK 221 +++ E + G +A+D+W+ GV L+ P+S+ + Sbjct: 190 RIQGRAVLPIRWMSWESIL-LGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIEN 248 Query: 222 I--------NAAEFSCPPWFSAEVKFLIHRILDPNPKTRIQIQGI 258 P V L+ + K R Q I Sbjct: 249 TGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEI 293 >4Y83-A nrPDB Length = 332 Score = 209 bits (533), Expect = 2e-54, Method: Composition-based stats. Identities = 62/253 (24%), Positives = 106/253 (41%), Gaps = 17/253 (6%) Query: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYE 76 I G F KV A++ T +A K++ + + I RH NI LY Sbjct: 81 IPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSD--------VEIQACFRHENIAELYG 132 Query: 77 VLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDLK 136 + +++ +E GG + +++ G + E E + ++ + H K V H D+K Sbjct: 133 AVLWGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHHDIK 192 Query: 137 PENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSAADIWSC 196 P N++ + + + DFGLS E V + GT Y++PEV+ +G+ + ADI+S Sbjct: 193 PSNIVFMSTKAV-LVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILCRGH-STKADIYSL 250 Query: 197 GVILFVILAGYLP----FSETDLPGLYRKINAAEFSCP---PWFSAEVKFLIHRILDPNP 249 G L + G P + + P I+ S ++ LI L+ NP Sbjct: 251 GATLIHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIADDCSPGMRELIEASLERNP 310 Query: 250 KTRIQIQGIKKDP 262 R + + K Sbjct: 311 NHRPRAADLLKHE 323 >4OW8-A nrPDB Length = 283 Score = 209 bits (533), Expect = 2e-54, Method: Composition-based stats. Identities = 65/251 (25%), Positives = 108/251 (43%), Gaps = 8/251 (3%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 G+Y + R I G +V A + G VA+K++ +++ + E ++ H Sbjct: 11 GRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNH 70 Query: 69 PNIVRLYEVLA-----SPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVA 123 P I +++ Y+V+E V G L + GRL + +Q A+ Sbjct: 71 PGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQ 130 Query: 124 HCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTC-GTPNYVAPEVLS 182 H G+ HRD+KP N+L+ G +K++DFG++ GT Y+APE Sbjct: 131 IAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQAL 190 Query: 183 GQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGL-YRKINAAEFSCPPWFSAEVKFLI 241 G A+D++S GV+ + ++G PF+ + + I PP V+ LI Sbjct: 191 GHD-ASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKEPPPPLPPDLPPNVRELI 249 Query: 242 HRILDPNPKTR 252 L NP R Sbjct: 250 EITLVKNPAMR 260 >4X3F-A nrPDB Length = 337 Score = 209 bits (533), Expect = 2e-54, Method: Composition-based stats. Identities = 65/251 (25%), Positives = 108/251 (43%), Gaps = 8/251 (3%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 G+Y + R I G +V A + G VA+K++ +++ + E ++ H Sbjct: 12 GRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNH 71 Query: 69 PNIVRLYEVLA-----SPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVA 123 P I +++ Y+V+E V G L + GRL + +Q A+ Sbjct: 72 PGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQ 131 Query: 124 HCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTC-GTPNYVAPEVLS 182 H G+ HRD+KP N+L+ G +K++DFG++ GT Y+APE Sbjct: 132 IAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQAL 191 Query: 183 GQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGL-YRKINAAEFSCPPWFSAEVKFLI 241 G A+D++S GV+ + ++G PF+ + + I PP V+ LI Sbjct: 192 GHD-ASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKEPPPPLPPDLPPNVRELI 250 Query: 242 HRILDPNPKTR 252 L NP R Sbjct: 251 EITLVKNPAMR 261 >6B2Q-A nrPDB Length = 317 Score = 209 bits (533), Expect = 2e-54, Method: Composition-based stats. Identities = 65/251 (25%), Positives = 108/251 (43%), Gaps = 8/251 (3%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 G+Y + R I G +V A + G VA+K++ +++ + E ++ H Sbjct: 32 GRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNH 91 Query: 69 PNIVRLYEVLA-----SPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVA 123 P I +++ Y+V+E V G L + GRL + +Q A+ Sbjct: 92 PGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQ 151 Query: 124 HCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTC-GTPNYVAPEVLS 182 H G+ HRD+KP N+L+ G +K++DFG++ GT Y+APE Sbjct: 152 IAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQAL 211 Query: 183 GQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGL-YRKINAAEFSCPPWFSAEVKFLI 241 G A+D++S GV+ + ++G PF+ + + I PP V+ LI Sbjct: 212 GHD-ASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKEPPPPLPPDLPPNVRELI 270 Query: 242 HRILDPNPKTR 252 L NP R Sbjct: 271 EITLVKNPAMR 281 >4TPT-A nrPDB Length = 303 Score = 208 bits (529), Expect = 5e-54, Method: Composition-based stats. Identities = 62/271 (22%), Positives = 115/271 (42%), Gaps = 33/271 (12%) Query: 14 GRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVR 73 G +G+G F + + TG + +K + + E+ +M+ + HPN+++ Sbjct: 5 GEVLGKGFFGQAIKVTHKATGKVMVMKELIRC---DEETQKTFLTEVKVMRSLDHPNVLK 61 Query: 74 LYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHR 133 VL K+ ++ E++ GG L D + + ++ + + +A+ H + HR Sbjct: 62 FIGVLYKDKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLHSMCIIHR 121 Query: 134 DLKPENLLLDTNGNLKVSDFGLSALPQE--------------------GVELLRTTCGTP 173 DL N L+ + + V+DFGLS L E + T G P Sbjct: 122 DLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGNP 181 Query: 174 NYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETD------LPGLYRKINAAEF 227 ++APE+L+G+ YD + DI+S G++L I+ G + +++ D GL K+ +F Sbjct: 182 YWMAPEMLNGKSYDET-VDIFSFGIVLCEII-GQV-YADPDCLPRTLDFGLNVKLFWEKF 238 Query: 228 SCPPWFSAEVKFLIHRILDPNPKTRIQIQGI 258 P L P++R + Sbjct: 239 -VPTDCPPAFFPLAAICCRLEPESRPAFSKL 268 >1S9I-A nrPDB Length = 354 Score = 207 bits (528), Expect = 6e-54, Method: Composition-based stats. Identities = 67/306 (21%), Positives = 121/306 (39%), Gaps = 54/306 (17%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 +E +G G V ++ +G +A K++ +K + +QI RE+ ++ Sbjct: 16 DDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLE--IKPAIRNQIIRELQVLHECNS 73 Query: 69 PNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCK 128 P IV Y S +I I +E + GG L + R+ E K ++ +A+ K Sbjct: 74 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREK 133 Query: 129 G-VYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYD 187 + HRD+KP N+L+++ G +K+ DFG+S + + + GT +Y+APE L G Y Sbjct: 134 HQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS--MANSFVGTRSYMAPERLQGTHY- 190 Query: 188 GSAADIWSCGVILFVILAGYLPFSETDLPGL----------------------------- 218 +DIWS G+ L + G P D L Sbjct: 191 SVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRPPGRP 250 Query: 219 --------------YRKINAAEFSCPPW-----FSAEVKFLIHRILDPNPKTRIQIQGIK 259 + ++ PP F+ + + +++ L NP R ++ + Sbjct: 251 VSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADLKMLT 310 Query: 260 KDPWFR 265 + + Sbjct: 311 NHTFIK 316 >4FL3-A nrPDB Length = 635 Score = 207 bits (527), Expect = 8e-54, Method: Composition-based stats. Identities = 54/250 (21%), Positives = 102/250 (40%), Gaps = 8/250 (3%) Query: 15 RTIGEGTFAKVKFARN-TDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVR 73 + +G G F VK + K+ + D++ E ++M+ + +P IVR Sbjct: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 Query: 74 LYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHR 133 + + + S + +V+E G L + +++ + Q+ + + HR Sbjct: 435 MIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHR 493 Query: 134 DLKPENLLLDTNGNLKVSDFGLSALP--QEGVELLRTTCGTP-NYVAPEVLSGQGYDGSA 190 DL N+LL T K+SDFGLS E +T P + APE ++ + S Sbjct: 494 DLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKF-SSK 552 Query: 191 ADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAAE-FSCPPWFSAEVKFLIHRILDPN 248 +D+WS GV+++ + G P+ + + E CP E+ L++ + Sbjct: 553 SDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYD 612 Query: 249 PKTRIQIQGI 258 + R + Sbjct: 613 VENRPGFAAV 622 >5UIU-A nrPDB Length = 323 Score = 206 bits (524), Expect = 2e-53, Method: Composition-based stats. Identities = 67/268 (25%), Positives = 107/268 (39%), Gaps = 25/268 (9%) Query: 14 GRTIGEGTFAKVKFARNTDTGDNVAIKIMA-KSTILKNRMVDQIKREISIMKIVRHPNIV 72 G +GEG F V +T VA+K +A I + Q +EI +M +H N+V Sbjct: 52 GNKMGEGGFGVVYKGYVNNT--TVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLV 109 Query: 73 RLYEVLASPSKIYIVLEFVTGGELFDRIV---HKGRLEESESRKYFQQLVDAVAHCHCKG 129 L + + +V ++ G L DR+ L K Q + + H Sbjct: 110 ELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENH 169 Query: 130 VYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTT--CGTPNYVAPEVLSGQGYD 187 HRD+K N+LLD K+SDFGL+ ++ + + T+ GT Y+APE L G+ Sbjct: 170 HIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGE--I 227 Query: 188 GSAADIWSCGVILFVILAGYLPFSETDLPGLY---------------RKINAAEFSCPPW 232 +DI+S GV+L I+ G E P L I+ Sbjct: 228 TPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADST 287 Query: 233 FSAEVKFLIHRILDPNPKTRIQIQGIKK 260 + + + L R I+ +++ Sbjct: 288 SVEAMYSVASQCLHEKKNKRPDIKKVQQ 315 >3QA8-A nrPDB Length = 676 Score = 205 bits (523), Expect = 2e-53, Method: Composition-based stats. Identities = 69/219 (31%), Positives = 103/219 (47%), Gaps = 16/219 (7%) Query: 4 KMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIM 63 + G +E+ +G G F V + DTG+ VAIK + KNR ++ EI IM Sbjct: 9 PTQTCGPWEMKERLGTGGFGYVLRWIHQDTGEQVAIKQCRQELSPKNR--ERWCLEIQIM 66 Query: 64 KIVRHPNIVRLYEV------LASPSKIYIVLEFVTGGELFDRI---VHKGRLEESESRKY 114 K + HPN+V EV LA + +E+ GG+L + + L+E R Sbjct: 67 KKLNHPNVVSAREVPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGPIRTL 126 Query: 115 FQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNL---KVSDFGLSALPQEGVELLRTTCG 171 + A+ + H + HRDLKPEN++L K+ D G + +G EL G Sbjct: 127 LSDISSALRYLHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQG-ELCTEFVG 185 Query: 172 TPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPF 210 T Y+APE+L + Y + D WS G + F + G+ PF Sbjct: 186 TLQYLAPELLEQKKYTVT-VDYWSFGTLAFECITGFRPF 223 >3EB0-A nrPDB Length = 383 Score = 205 bits (522), Expect = 3e-53, Method: Composition-based stats. Identities = 70/326 (21%), Positives = 117/326 (35%), Gaps = 79/326 (24%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 KY +G+T+G G+F V + ++G A+K + + KN RE+ IMK++ H Sbjct: 8 KYSLGKTLGTGSFGIVCEVFDIESGKRFALKKVLQDPRYKN-------RELDIMKVLDHV 60 Query: 70 NIVRLYEVLAS--------------------------------------PSKIYIVLEFV 91 NI++L + + + +++E+V Sbjct: 61 NIIKLVDYFYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNVIMEYV 120 Query: 92 T---GGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDT-NGN 147 L I + + Y QL AV H G+ HRD+KP+NLL+++ + Sbjct: 121 PDTLHKVLKSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLLVNSKDNT 180 Query: 148 LKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGY 207 LK+ DFG + + C + Y APE++ G + D+WS G + ++ G Sbjct: 181 LKLCDFGSAKKLIPSEPSVAYIC-SRFYRAPELMLGATEYTPSIDLWSIGCVFGELILGK 239 Query: 208 LPFSETDLPGLYRKI-------------------NAAEFS----------CPPWFSAEVK 238 FS +I F P + Sbjct: 240 PLFSGETSIDQLVRIIQIMGTPTKEQMIRMNPHYTEVRFPTLKAKDWRKILPEGTPSLAI 299 Query: 239 FLIHRILDPNPKTRIQIQGIKKDPWF 264 L+ +IL P RI P+F Sbjct: 300 DLLEQILRYEPDLRINPYEAMAHPFF 325 >5ZTN-A nrPDB Length = 429 Score = 205 bits (521), Expect = 4e-53, Method: Composition-based stats. Identities = 70/325 (21%), Positives = 114/325 (35%), Gaps = 78/325 (24%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 +YEV + IG+G+F +V A + +VA+K++ + R Q EI I++ +R Sbjct: 98 RYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRN----EKRFHRQAAEEIRILEHLRKQ 153 Query: 70 ------NIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKG--RLEESESRKYFQQLVDA 121 N++ + E + I + E ++ L++ I RK+ ++ Sbjct: 154 DKDNTMNVIHMLENFTFRNHICMTFELLSM-NLYELIKKNKFQGFSLPLVRKFAHSILQC 212 Query: 122 VAHCHCKGVYHRDLKPENLLLDTNGN--LKVSDFGLSALPQEGVELLRTTCGTPNYVAPE 179 + H + H DLKPEN+LL G +KV DFG S + + T + Y APE Sbjct: 213 LDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEH---QRVYTYIQSRFYRAPE 269 Query: 180 VLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYR------------------- 220 V+ G Y G D+WS G IL +L GY D Sbjct: 270 VILGARY-GMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKR 328 Query: 221 -----------------------------KINAAEFSCPPW-----------FSAEVKFL 240 + + PP Sbjct: 329 AKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDF 388 Query: 241 IHRILDPNPKTRIQIQGIKKDPWFR 265 + + L+ +P R+ + PW R Sbjct: 389 LKQCLEWDPAVRMTPGQALRHPWLR 413 >4M7I-A nrPDB Length = 299 Score = 203 bits (517), Expect = 1e-52, Method: Composition-based stats. Identities = 76/295 (25%), Positives = 122/295 (41%), Gaps = 37/295 (12%) Query: 6 RRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKI 65 R + +E + +G G F V A+N N AIK + + +++ RE+ + Sbjct: 2 RYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPN--RELAREKVMREVKALAK 59 Query: 66 VRHPNIVRLYEVLASPS------------KIYIVLEFVTGGELFDRIVHKGRLEESES-- 111 + HP IVR + + +YI ++ L D + + +EE E Sbjct: 60 LEHPGIVRYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSV 119 Query: 112 -RKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVE------ 164 F Q+ +AV H KG+ HRDLKP N+ + +KV DFGL + E Sbjct: 120 CLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLT 179 Query: 165 ------LLRTTCGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGL 218 GT Y++PE + G Y DI+S G+ILF +L PFS T + + Sbjct: 180 PMPAYARHTGQVGTKLYMSPEQIHGNSY-SHKVDIFSLGLILFELL---YPFS-TQMERV 234 Query: 219 YRKINAAEFSCPPWFSAEVKF---LIHRILDPNPKTRIQIQGIKKDPWFRLNYVP 270 + PP F+ + ++ +L P+P R + I ++ F P Sbjct: 235 RTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFP 289 >5C26-A nrPDB Length = 299 Score = 203 bits (516), Expect = 1e-52, Method: Composition-based stats. Identities = 54/250 (21%), Positives = 102/250 (40%), Gaps = 8/250 (3%) Query: 15 RTIGEGTFAKVKFARN-TDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVR 73 + +G G F VK + K+ + D++ E ++M+ + +P IVR Sbjct: 33 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 92 Query: 74 LYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHR 133 + + + S + +V+E G L + +++ + Q+ + + HR Sbjct: 93 MIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHR 151 Query: 134 DLKPENLLLDTNGNLKVSDFGLSALP--QEGVELLRTTCGTP-NYVAPEVLSGQGYDGSA 190 DL N+LL T K+SDFGLS E +T P + APE ++ + S Sbjct: 152 DLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKF-SSK 210 Query: 191 ADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAAE-FSCPPWFSAEVKFLIHRILDPN 248 +D+WS GV+++ + G P+ + + E CP E+ L++ + Sbjct: 211 SDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYD 270 Query: 249 PKTRIQIQGI 258 + R + Sbjct: 271 VENRPGFAAV 280 >5CEK-A nrPDB Length = 263 Score = 203 bits (516), Expect = 2e-52, Method: Composition-based stats. Identities = 71/244 (29%), Positives = 114/244 (46%), Gaps = 12/244 (4%) Query: 25 VKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYEVLASPSKI 84 V A TG + K+ ++++ I+ + H NI + EV+ +K Sbjct: 25 VSRALCIHTGRELRCKVFPIK-HYQDKIRPYIQ-------LPSHSNITGIVEVILGETKA 76 Query: 85 YIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLLD- 143 Y+ E G++ + + RL E E+ + F+Q+V AVAHCH + DLK + Sbjct: 77 YVFFE-KDFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFST 135 Query: 144 -TNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQG-YDGSAADIWSCGVILF 201 L++ + + + + L G P YV+PE+L+ G Y G AAD+WS GV+L+ Sbjct: 136 EERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLY 195 Query: 202 VILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILDPNPKTRIQIQGIKKD 261 +L G PF ++D L+ KI +F P S + + LI +L P R+ I Sbjct: 196 TLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKARCLIRSLLRREPSERLTAPEILLH 255 Query: 262 PWFR 265 PWF Sbjct: 256 PWFE 259 >6DC0-A nrPDB Length = 292 Score = 203 bits (516), Expect = 2e-52, Method: Composition-based stats. Identities = 71/244 (29%), Positives = 114/244 (46%), Gaps = 12/244 (4%) Query: 25 VKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYEVLASPSKI 84 V A TG + K+ ++++ I+ + H NI + EV+ +K Sbjct: 22 VSRALCIHTGRELRCKVFPIK-HYQDKIRPYIQ-------LPSHSNITGIVEVILGETKA 73 Query: 85 YIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLLD- 143 Y+ E G++ + + RL E E+ + F+Q+V AVAHCH + DLK + Sbjct: 74 YVFFE-KDFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFST 132 Query: 144 -TNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQG-YDGSAADIWSCGVILF 201 L++ + + + + L G P YV+PE+L+ G Y G AAD+WS GV+L+ Sbjct: 133 EERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLY 192 Query: 202 VILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILDPNPKTRIQIQGIKKD 261 +L G PF ++D L+ KI +F P S + + LI +L P R+ I Sbjct: 193 TLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKARCLIRSLLRREPSERLTAPEILLH 252 Query: 262 PWFR 265 PWF Sbjct: 253 PWFE 256 >4C59-A nrPDB Length = 340 Score = 203 bits (516), Expect = 2e-52, Method: Composition-based stats. Identities = 78/278 (28%), Positives = 118/278 (42%), Gaps = 36/278 (12%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR-H 68 + V R + EG FA V A++ +G A+K + + KNR I +E+ MK + H Sbjct: 28 RLRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNR---AIIQEVCFMKKLSGH 84 Query: 69 PNIVRL-----YEVLASPS---KIYIVLEFVTGG--ELFDRIVHKGRLEESESRKYFQQL 118 PNIV+ S + + ++ E G E ++ +G L K F Q Sbjct: 85 PNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGPLSCDTVLKIFYQT 144 Query: 119 VDAVAHCHCKG--VYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLR--------- 167 AV H H + + HRDLK ENLLL G +K+ DFG + + Sbjct: 145 CRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVE 204 Query: 168 ---TTCGTPNYVAPEVLSGQGYD--GSAADIWSCGVILFVILAGYLPFSETDLPGLYRKI 222 T TP Y PE++ G DIW+ G IL+++ PF + G +I Sbjct: 205 EEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFED----GAKLRI 260 Query: 223 NAAEFSCPPWFSAE--VKFLIHRILDPNPKTRIQIQGI 258 ++S PP + LI +L NP+ R+ I + Sbjct: 261 VNGKYSIPPHDTQYTVFHSLIRAMLQVNPEERLSIAEV 298 >5X8I-B nrPDB Length = 346 Score = 202 bits (515), Expect = 2e-52, Method: Composition-based stats. Identities = 79/327 (24%), Positives = 119/327 (36%), Gaps = 81/327 (24%) Query: 10 KYEVGRTIGEGTFAKVKFAR-NTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR- 67 +YE+ T+GEG F KV + G +VA+KI+ +R + + EI +++ + Sbjct: 14 RYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNV----DRYCEAARSEIQVLEHLNT 69 Query: 68 -HPN----IVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLE--ESESRKYFQQLVD 120 PN V++ E I IV E + G +D I G L RK Q+ Sbjct: 70 TDPNSTFRCVQMLEWFEHHGHICIVFELL-GLSTYDFIKENGFLPFRLDHIRKMAYQICK 128 Query: 121 AVAHCHCKGVYHRDLKPENLLLDT-------------------NGNLKVSDFGLSALPQE 161 +V H + H DLKPEN+L N ++KV DFG + Sbjct: 129 SVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATY--- 185 Query: 162 GVELLRTTCGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRK 221 E T T +Y APEV+ G+ D+WS G IL G+ F D Sbjct: 186 DDEHHSTLVSTRHYRAPEVILALGW-SQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAM 244 Query: 222 INAAEFSCPPW---------------------------------------FSAEVK---- 238 + P S +V+ Sbjct: 245 MERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQDVEHERL 304 Query: 239 -FLIHRILDPNPKTRIQIQGIKKDPWF 264 LI ++L+ +P RI ++ K P+F Sbjct: 305 FDLIQKMLEYDPAKRITLREALKHPFF 331 >4IDT-A nrPDB Length = 356 Score = 202 bits (513), Expect = 4e-52, Method: Composition-based stats. Identities = 73/309 (23%), Positives = 123/309 (39%), Gaps = 42/309 (13%) Query: 1 MTKKMRRVGKYEVGRT---------IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNR 51 +T+K++ V YE +G G+F +V + TG A+K + Sbjct: 58 LTEKLKPVD-YEYREEVHWATHQLRLGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRAE- 115 Query: 52 MVDQIKREISIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESES 111 E+ + P IV LY + + I +E + GG L + +G L E + Sbjct: 116 -------ELMACAGLTSPRIVPLYGAVREGPWVNIFMELLEGGSLGQLVKEQGCLPEDRA 168 Query: 112 RKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNG-NLKVSDFGLSALPQE---GVELLR 167 Y Q ++ + + H + + H D+K +N+LL ++G + + DFG + Q G +LL Sbjct: 169 LYYLGQALEGLEYLHSRRILHGDVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKDLLT 228 Query: 168 T--TCGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAA 225 GT ++APEV+ G+ D D+WS ++ +L G P+++ L KI + Sbjct: 229 GDYIPGTETHMAPEVVLGRSCDA-KVDVWSSCCMMLHMLNGCHPWTQFFRGPLCLKIASE 287 Query: 226 EFS---CPPWFSAEVKFLIHRILDPNPKTRIQIQGI-------------KKDPWFRLNYV 269 PP + I L P R+ + K PW R Y Sbjct: 288 PPPVREIPPSCAPLTAQAIQEGLRKEPIHRVSAAELGGKVNRALQQVGGLKSPW-RGEYK 346 Query: 270 PIRAREEEE 278 R + Sbjct: 347 EPRHPPPNQ 355 >5TQX-A nrPDB Length = 655 Score = 202 bits (513), Expect = 4e-52, Method: Composition-based stats. Identities = 76/280 (27%), Positives = 126/280 (45%), Gaps = 26/280 (9%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 G +E+ +G G F V ++ + +AIK KNR ++ EI IMK + H Sbjct: 8 GPWEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNR--ERWCHEIQIMKKLNH 65 Query: 69 PNIVRLYEVLASPSKIYIV--------LEFVTGGELFDRI---VHKGRLEESESRKYFQQ 117 N+V+ P ++ I+ +E+ +GG+L + + L+ES+ Sbjct: 66 ANVVK---ACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSD 122 Query: 118 LVDAVAHCHCKGVYHRDLKPENLLL-DTNGNL--KVSDFGLSALPQEGVELLRTTCGTPN 174 + + + H + HRDLKPEN++L D G + K+ D G + +G EL GT Sbjct: 123 IGSGIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQG-ELCTEFVGTLQ 181 Query: 175 YVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLY-RKINAAEFSC---P 230 Y+APE+ + Y + D WS G ++F +AGY PF P + KI + C Sbjct: 182 YLAPELFENKPYTAT-VDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPKCIFAC 240 Query: 231 PWFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVP 270 S EV+ + PN + ++ ++ LN+ P Sbjct: 241 EEMSGEVR-FSSHLPQPNSLCSLIVEPMENWLQLMLNWDP 279 >5B2L-A nrPDB Length = 324 Score = 201 bits (511), Expect = 6e-52, Method: Composition-based stats. Identities = 62/272 (22%), Positives = 116/272 (42%), Gaps = 15/272 (5%) Query: 5 MRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMK 64 + E +G GT +V R TG +A+K M +S + + ++ ++K Sbjct: 13 QAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDV-VLK 71 Query: 65 IVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHK--GRLEESESRKYFQQLVDAV 122 P IV+ + + + ++I +E + G +++ + G + E K +V A+ Sbjct: 72 SHDCPYIVQCFGTFITNTDVFIAMELM--GTSAEKLKKRMQGPIPERILGKMTVAIVKAL 129 Query: 123 AHC-HCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVL 181 + GV HRD+KP N+LLD G +K+ DFG+S + R+ G Y+APE + Sbjct: 130 YYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRS-AGCAAYMAPERI 188 Query: 182 S----GQGYDGSAADIWSCGVILFVILAGYLPFSETDLP-GLYRKINAAEFSCPP---WF 233 + AD+WS G+ L + G P+ + K+ E P F Sbjct: 189 DPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGF 248 Query: 234 SAEVKFLIHRILDPNPKTRIQIQGIKKDPWFR 265 S + + + L + + R + + + + + Sbjct: 249 SGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIK 280 >4KIK-B nrPDB Length = 677 Score = 200 bits (509), Expect = 1e-51, Method: Composition-based stats. Identities = 64/245 (26%), Positives = 105/245 (42%), Gaps = 16/245 (6%) Query: 5 MRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMK 64 + G +E+ +G G F V N +TG+ +AIK + L R ++ EI IM+ Sbjct: 15 TQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQE--LSPRNRERWCLEIQIMR 72 Query: 65 IVRHPNIVRLYEVLASPSKI------YIVLEFVTGGELFDRI---VHKGRLEESESRKYF 115 + HPN+V +V + + +E+ GG+L + + L E Sbjct: 73 RLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLL 132 Query: 116 QQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNL---KVSDFGLSALPQEGVELLRTTCGT 172 + A+ + H + HRDLKPEN++L K+ D G + +G L + GT Sbjct: 133 SDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQG-SLCTSFVGT 191 Query: 173 PNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPW 232 Y+APE+L Q Y + D WS G + F + G+ PF P + + Sbjct: 192 LQYLAPELLEQQKYTVT-VDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIV 250 Query: 233 FSAEV 237 S ++ Sbjct: 251 VSEDL 255 >4F0G-A nrPDB Length = 287 Score = 200 bits (508), Expect = 1e-51, Method: Composition-based stats. Identities = 72/269 (26%), Positives = 120/269 (44%), Gaps = 22/269 (8%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMV----DQIKREISIMK 64 + E + IG+G F V R VAIK + + + +RE+ IM Sbjct: 19 NEIEYEKQIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQREVFIMS 78 Query: 65 IVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHK-GRLEESESRKYFQQLVDAVA 123 + HPNIV+LY ++ +P + +V+EFV G+L+ R++ K ++ S + + + Sbjct: 79 NLNHPNIVKLYGLMHNPPR--MVMEFVPCGDLYHRLLDKAHPIKWSVKLRLMLDIALGIE 136 Query: 124 HCHCKG--VYHRDLKPENLL---LDTNGNL--KVSDFGLSALPQEGVELLRTTCGTPNYV 176 + + + HRDL+ N+ LD N + KV+DFGLS Q+ V + G ++ Sbjct: 137 YMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLS---QQSVHSVSGLLGNFQWM 193 Query: 177 APEVL-SGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGL--YRKINAA--EFSCPP 231 APE + + + AD +S +IL+ IL G PF E + I + P Sbjct: 194 APETIGAEEESYTEKADTYSFAMILYTILTGEGPFDEYSYGKIKFINMIREEGLRPTIPE 253 Query: 232 WFSAEVKFLIHRILDPNPKTRIQIQGIKK 260 ++ +I +PK R I K Sbjct: 254 DCPPRLRNVIELCWSGDPKKRPHFSYIVK 282 >3ZZW-A nrPDB Length = 289 Score = 199 bits (507), Expect = 2e-51, Method: Composition-based stats. Identities = 58/272 (21%), Positives = 107/272 (39%), Gaps = 28/272 (10%) Query: 12 EVGRTIGEGTFAKVKFARNT-----DTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIV 66 +GE F KV + VAIK + + + ++ + E + + Sbjct: 12 RFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKA--EGPLREEFRHEAMLRARL 69 Query: 67 RHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGR----------------LEESE 110 +HPN+V L V+ + ++ + + G+L + +V + LE + Sbjct: 70 QHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPD 129 Query: 111 SRKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQ--EGVELLRT 168 Q+ + + V H+DL N+L+ N+K+SD GL + +LL Sbjct: 130 FVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGN 189 Query: 169 TCGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAAE- 226 + ++APE + G +DIWS GV+L+ + + G P+ + I + Sbjct: 190 SLLPIRWMAPEAIMY-GKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQV 248 Query: 227 FSCPPWFSAEVKFLIHRILDPNPKTRIQIQGI 258 CP A V L+ + P R + + I Sbjct: 249 LPCPDDCPAWVYALMIECWNEFPSRRPRFKDI 280 >5VD3-A nrPDB Length = 311 Score = 199 bits (506), Expect = 3e-51, Method: Composition-based stats. Identities = 68/259 (26%), Positives = 116/259 (44%), Gaps = 10/259 (3%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIV-RHP 69 ++ +G G++ +V R+ + G A+K + S + + E+ + V +HP Sbjct: 59 FQRLSRLGHGSYGEVFKVRSKEDGRLYAVKR-SMSPFRGPKDRARKLAEVGSHEKVGQHP 117 Query: 70 NIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKG-RLEESESRKYFQQLVDAVAHCHCK 128 VRL + +Y+ E G L G L E++ Y + + A+AH H + Sbjct: 118 CCVRLEQAWEEGGILYLQTELC-GPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQ 176 Query: 129 GVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDG 188 G+ H D+KP N+ L G K+ DFGL G P Y+APE+L G G Sbjct: 177 GLVHLDVKPANIFLGPRGRCKLGDFGLLVEL-GTAGAGEVQEGDPRYMAPELLQGS--YG 233 Query: 189 SAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILDP 247 +AAD++S G+ + + LP L + EF+ S+E++ ++ +L+P Sbjct: 234 TAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFT--AGLSSELRSVLVMMLEP 291 Query: 248 NPKTRIQIQGIKKDPWFRL 266 +PK R + + P R Sbjct: 292 DPKLRATAEALLALPVLRQ 310 >6CTH-A nrPDB Length = 309 Score = 198 bits (505), Expect = 3e-51, Method: Composition-based stats. Identities = 67/279 (24%), Positives = 122/279 (43%), Gaps = 29/279 (10%) Query: 6 RRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKI 65 + + +GEG F V D+ +A+K ++++ + + + E+ I+ Sbjct: 12 KVTSNFNAENKLGEGGFGSVYRGFLRDSDTYIAVKKVSRA---SKQGIKEYASEVKIISR 68 Query: 66 VRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESR-KYFQQLVDAVAH 124 +RH N+V+L ++ +V EF+ G L I L E R + + L A+ + Sbjct: 69 LRHKNLVKLIGWCHERGELMLVYEFMANGSLDSHIFKGKSLLTWEVRYRIVKDLASALLY 128 Query: 125 CHCKG---VYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRT-TCGTPNYVAPEV 180 H +G V HRD+K N++LD++ N K+ DFGL+ L L +T GT Y+APE Sbjct: 129 LHEEGDHCVLHRDIKTSNIMLDSSFNAKLGDFGLARLVDHAKGLKKTLLAGTVGYMAPEC 188 Query: 181 LSGQGYDGSAADIWSCGVILFVILAGY---------------LPF-SETDLPGLYRKINA 224 LS G +D++S GV+ I +G +P+ E+ I Sbjct: 189 LS-SGKASKESDVYSFGVVALEIASGRRSIEPKFEESEALLLVPWVWESYGNERILDIAD 247 Query: 225 AEFSCPPWFSAEVKFL-IHRILDPNPKT--RIQIQGIKK 260 + + +++ L + + +P R I+ + + Sbjct: 248 RKLGM-AFDPKQLECLVMVGLWCAHPSHNLRPSIRQVIQ 285 >5WNL-A nrPDB Length = 342 Score = 198 bits (503), Expect = 5e-51, Method: Composition-based stats. Identities = 57/265 (21%), Positives = 116/265 (43%), Gaps = 18/265 (6%) Query: 8 VGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR 67 G++ +G G F +V R+ +AIK + S + +R ++ E M++ + Sbjct: 19 AGEFAGWEKVGSGGFGQVYKVRHVHWKTWLAIKC-SPSLHVDDRERMELLEEAKKMEMAK 77 Query: 68 HPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHC 127 I+ +Y + P + +V+E++ G L ++++ L + + + HC Sbjct: 78 FRYILPVYGICQEP--VGLVMEYMETGSL-EKLLASEPLPWDLRFRIVHETAVGMNFLHC 134 Query: 128 KG--VYHRDLKPENLLLDTNGNLKVSDFGLSA---LPQEGVELLRTTCGTPNYVAPEVLS 182 + H +LKP N+LLD + ++K+SDFGL+ + + GT Y+ PE + Sbjct: 135 MSPPLLHLNLKPANILLDAHYHVKISDFGLAKCNGMSHSHDLSMDGLFGTIAYLPPERIR 194 Query: 183 GQGY-DGSAADIWSCGVILFVILAGYLPFSETD--LPGLYRKINAAEFSCPPWF------ 233 + + D++S ++++ +L PF++ L + + + PP Sbjct: 195 EKSRLFDTKHDVYSFAIVIWGVLTQKKPFADEKNILHIMMKVVKGHRPELPPICRPRPRA 254 Query: 234 SAEVKFLIHRILDPNPKTRIQIQGI 258 A + L+ R +P+ R Q I Sbjct: 255 CASLIGLMQRCWHADPQVRPTFQEI 279 >5TOS-A nrPDB Length = 395 Score = 197 bits (501), Expect = 8e-51, Method: Composition-based stats. Identities = 66/289 (22%), Positives = 108/289 (37%), Gaps = 45/289 (15%) Query: 10 KYEVGRTIGEGTFAKVKFARNTD---------TGDNVAIKIMAKSTILKNRMVDQIKREI 60 + IGEG F V + TG +A+K + + +R + EI Sbjct: 66 NFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHR---EWLTEI 122 Query: 61 SIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKG----RLEESESRKYFQ 116 + + + HPN+V+L +V EF+ G L + + +G L Sbjct: 123 NYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVAL 182 Query: 117 QLVDAVAHCHCK--GVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGV--ELLRTTCGT 172 +A H V +RD+K N+LLD + N K+SDFGL+ G + GT Sbjct: 183 DAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGT 242 Query: 173 PNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGY------------------LPFSETD 214 Y APE G+ + +D++S GV+L IL+G P+ + Sbjct: 243 YGYAAPE-YMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSK 301 Query: 215 LPGLYRKINAAEFSCPPWFSAEV---KFLIHRILDPNPKTRIQIQGIKK 260 L I + E + + L PK+R + + + Sbjct: 302 RKVLL--IVDNRLDT-QYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVR 347 >6FYV-A nrPDB Length = 337 Score = 196 bits (498), Expect = 2e-50, Method: Composition-based stats. Identities = 72/327 (22%), Positives = 114/327 (34%), Gaps = 81/327 (24%) Query: 10 KYEVGRTIGEGTFAKVKFARNTD-TGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 +YE+ T+GEG F KV + G +VA+KI+ R + + EI +++ + Sbjct: 15 RYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNV----GRYREAARSEIQVLEHLNS 70 Query: 69 --PN----IVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLE--ESESRKYFQQLVD 120 PN V++ E + IV E + G +D I L R+ Q+ Sbjct: 71 TDPNSVFRCVQMLEWFDHHGHVCIVFELL-GLSTYDFIKENSFLPFQIDHIRQMAYQICQ 129 Query: 121 AVAHCHCKGVYHRDLKPENLLLD-------------------TNGNLKVSDFGLSALPQE 161 ++ H + H DLKPEN+L N ++KV DFG + Sbjct: 130 SINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATY--- 186 Query: 162 GVELLRTTCGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRK 221 E T T +Y APEV+ G+ D+WS G IL G+ F D Sbjct: 187 DDEHHSTLVSTRHYRAPEVILALGW-SQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAM 245 Query: 222 INAAEFSCPPWF--------------------------------------------SAEV 237 + P ++ Sbjct: 246 MERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKL 305 Query: 238 KFLIHRILDPNPKTRIQIQGIKKDPWF 264 L+ R+L+ +P RI + + P+F Sbjct: 306 FDLVRRMLEYDPTQRITLDEALQHPFF 332 >2WTK-B nrPDB Length = 373 Score = 195 bits (497), Expect = 2e-50, Method: Composition-based stats. Identities = 68/326 (20%), Positives = 122/326 (37%), Gaps = 63/326 (19%) Query: 1 MTKKMRRVGKYEVGRTIGEGTF---AKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIK 57 M+ + G YE+ IG+G F V AR TG+ V ++ + N MV ++ Sbjct: 1 MSSFLPEGGCYELLTVIGKG-FEDLMTVNLARYKPTGEYVTVRRINLEAC-SNEMVTFLQ 58 Query: 58 REISIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHK--GRLEESESRKYF 115 E+ + K+ HPNIV + +++++V F+ G D I + E Sbjct: 59 GELHVSKLFNHPNIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYIL 118 Query: 116 QQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDF--GLSALPQEG-----VELLRT 168 Q ++ A+ + H G HR +K ++L+ +G + +S LS + + + Sbjct: 119 QGVLKALDYIHHMGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKY 178 Query: 169 TCGTPNYVAPEVLSG--QGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRK----- 221 + +++PEVL QGYD +DI+S G+ + G++PF + + + Sbjct: 179 SVKVLPWLSPEVLQQNLQGYDA-KSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGT 237 Query: 222 ---------INAAEFSCPPW--------------------------------FSAEVKFL 240 I A E + P FS Sbjct: 238 VPCLLDTSTIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFSPHFHHF 297 Query: 241 IHRILDPNPKTRIQIQGIKKDPWFRL 266 + + L NP R + +F+ Sbjct: 298 VEQCLQRNPDARPSASTLLNHSFFKQ 323 >3LMG-A nrPDB Length = 344 Score = 194 bits (494), Expect = 6e-50, Method: Composition-based stats. Identities = 57/266 (21%), Positives = 118/266 (44%), Gaps = 10/266 (3%) Query: 14 GRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKN--RMVDQIKREISIMKIVRHPNI 71 + +G G F V G+++ I + K K+ + + + + + H +I Sbjct: 36 LKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHI 95 Query: 72 VRLYEVLASPSKIYIVLEFVTGGELFDRIV-HKGRLEESESRKYFQQLVDAVAHCHCKGV 130 VRL + S + +V +++ G L D + H+G L + Q+ + + G+ Sbjct: 96 VRLLGLC-PGSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEHGM 154 Query: 131 YHRDLKPENLLLDTNGNLKVSDFGLSA-LPQEGVELLRTTCGTP-NYVAPEVLSGQGYDG 188 HR+L N+LL + ++V+DFG++ LP + +LL + TP ++A E + Y Sbjct: 155 VHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHFGKY-T 213 Query: 189 SAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAAE-FSCPPWFSAEVKFLIHRILD 246 +D+WS GV ++ ++ G P++ L + + E + P + +V ++ + Sbjct: 214 HQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCWM 273 Query: 247 PNPKTRIQIQGIKKDPWFRLNYVPIR 272 + R + + + R+ P R Sbjct: 274 IDENIRPTFKELAN-EFTRMARDPPR 298 >5TE0-A nrPDB Length = 347 Score = 193 bits (492), Expect = 9e-50, Method: Composition-based stats. Identities = 81/307 (26%), Positives = 133/307 (43%), Gaps = 41/307 (13%) Query: 12 EVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR-HPN 70 V + EG FA V R T G A+K M + + KREI IM+ + H N Sbjct: 22 TVDEVLAEGGFAIVFLVR-TSNGMKCALKRMFVNN---EHDLQVCKREIQIMRDLSGHKN 77 Query: 71 IVRLYEV----LASPS--KIYIVLEFVTGGELFDRIVHK--GRLEESESRKYFQQLVDAV 122 IV + ++S ++ I+++F GG++ + + + E+E + F +AV Sbjct: 78 IVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAV 137 Query: 123 AHCHCKG--VYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCG--------T 172 A H + HRDLK EN+LL G+ + DFG + + + T Sbjct: 138 ARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTT 197 Query: 173 PNYVAPEVLSGQ--GYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCP 230 +Y APE+++ + ADIW+ G +L+ + LPF E+ + I F+ P Sbjct: 198 LSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPFGESQVA-----ICDGNFTIP 252 Query: 231 P--WFSAEVKFLIHRILDPNPKTRIQIQGI---------KKDPWFRLNYVPIRAREEEEV 279 +S ++ LI +L+P+P R I + K+ P + PI A+ E V Sbjct: 253 DNSRYSQDMHCLIRYMLEPDPDKRPDIYQVSYFSFKLLKKECPIPNVQNSPIPAKLPEPV 312 Query: 280 NLDDIRA 286 + A Sbjct: 313 KASEAAA 319 >2H34-A nrPDB Length = 309 Score = 193 bits (490), Expect = 1e-49, Method: Composition-based stats. Identities = 62/250 (24%), Positives = 115/250 (46%), Gaps = 5/250 (2%) Query: 7 RVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIV 66 + G Y + R +G G V A +T VA+K+M+++ +++RE + Sbjct: 32 QFGPYRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRTRMQREARTAGRL 91 Query: 67 RHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCH 126 + P++V +++ ++Y+ + + G +L + +G L + +Q+ A+ H Sbjct: 92 QEPHVVPIHDFGEIDGQLYVDMRLINGVDLAAMLRRQGPLAPPRAVAIVRQIGSALDAAH 151 Query: 127 CKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGV-ELLRTTCGTPNYVAPEVLSGQG 185 G HRD+KPEN+L+ + + DFG+++ + L T GT Y+APE S + Sbjct: 152 AAGATHRDVKPENILVSADDFAYLVDFGIASATTDEKLTQLGNTVGTLYYMAPERFS-ES 210 Query: 186 YDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAA---EFSCPPWFSAEVKFLIH 242 + ADI++ +L+ L G P+ L + IN A + P +I Sbjct: 211 HATYRADIYALTCVLYECLTGSPPYQGDQLSVMGAHINQAIPRPSTVRPGIPVAFDAVIA 270 Query: 243 RILDPNPKTR 252 R + NP+ R Sbjct: 271 RGMAKNPEDR 280 >3RP9-A nrPDB Length = 458 Score = 192 bits (488), Expect = 3e-49, Method: Composition-based stats. Identities = 56/235 (23%), Positives = 93/235 (39%), Gaps = 34/235 (14%) Query: 3 KKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISI 62 + +YE+ IG G++ V A + VAIK + + +I REI+I Sbjct: 47 SDWQIPDRYEIRHLIGTGSYGHVCEAYDKLEKRVVAIKKILR-VFEDLIDCKRILREIAI 105 Query: 63 MKIVRHPNIVRLYEVLASPS-----KIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQ 117 + + H ++V++ +++ ++Y+VLE + L E + Sbjct: 106 LNRLNHDHVVKVLDIVIPKDVEKFDELYVVLEIAD-SDFKKLFRTPVYLTELHIKTLLYN 164 Query: 118 LVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEG--------------- 162 L+ V + H G+ HRDLKP N L++ + ++KV DFGL+ Sbjct: 165 LLVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFGLARTVDYPENGNSQLPISPREDD 224 Query: 163 ------------VELLRTTCGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILA 205 L T Y APE++ Q A D+WS G I +L Sbjct: 225 MNLVTFPHTKNLKRQLTGHVVTRWYRAPELILLQENYTEAIDVWSIGCIFAELLN 279 Score = 53.7 bits (128), Expect = 2e-07, Method: Composition-based stats. Identities = 18/60 (30%), Positives = 27/60 (45%), Gaps = 4/60 (6%) Query: 231 PWFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEVNLDDIRAVFDG 290 P SA+ L+ R+L NP RI I P+F+ +R E E + +R F+ Sbjct: 367 PASSADAIHLLKRMLVFNPNKRITINECLAHPFFK----EVRIAEVETNATEKVRLPFND 422 >2PMN-X nrPDB Length = 348 Score = 192 bits (487), Expect = 4e-49, Method: Composition-based stats. Identities = 69/308 (22%), Positives = 131/308 (42%), Gaps = 48/308 (15%) Query: 1 MTKKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRM-------- 52 + +K + + Y + RT+ +G F K+ A+K KS + K R Sbjct: 23 VKEKDKYINDYRIIRTLNQGKFNKIILCE--KDNKFYALKKYEKSLLEKKRDFTKSNNDK 80 Query: 53 ------VDQIKREISIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRL 106 D K E+ I+ +++ + ++ + ++YI+ E++ + + L Sbjct: 81 ISIKSKYDDFKNELQIITDIKNEYCLTCEGIITNYDEVYIIYEYMENDSILKFDEYFFVL 140 Query: 107 EES--------ESRKYFQQLVDAVAHCH-CKGVYHRDLKPENLLLDTNGNLKVSDFGLSA 157 +++ + + ++++ ++ H K + HRD+KP N+L+D NG +K+SDFG S Sbjct: 141 DKNYTCFIPIQVIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMDKNGRVKLSDFGESE 200 Query: 158 LPQEGVELLRTTCGTPNYVAPEVLSGQ-GYDGSAADIWSCGVILFVILAGYLPFS-ETDL 215 + + ++ + GT ++ PE S + Y+G+ DIWS G+ L+V+ +PFS + L Sbjct: 201 YMVD--KKIKGSRGTYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMFYNVVPFSLKISL 258 Query: 216 PGLYRKINAAEFSCP-------------------PWFSAEVKFLIHRILDPNPKTRIQIQ 256 L+ I P + S E + L NP RI + Sbjct: 259 VELFNNIRTKNIEYPLDRNHFLYPLTNKKSTCSNNFLSNEDIDFLKLFLRKNPAERITSE 318 Query: 257 GIKKDPWF 264 K W Sbjct: 319 DALKHEWL 326 >2A1A-B nrPDB Length = 284 Score = 191 bits (486), Expect = 5e-49, Method: Composition-based stats. Identities = 62/269 (23%), Positives = 113/269 (42%), Gaps = 31/269 (11%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 ++ IG G F +V A++ G IK + + ++ +RE+ + + H Sbjct: 12 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNN-------EKAEREVKALAKLDHV 64 Query: 70 NIVRLYEVL----------------ASPSKIYIVLEFVTGGELFDRIVHK--GRLEESES 111 NIV + ++I +EF G L I + +L++ + Sbjct: 65 NIVHYNGCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLA 124 Query: 112 RKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCG 171 + F+Q+ V + H K + +RDLKP N+ L +K+ DFGL + + R+ G Sbjct: 125 LELFEQITKGVDYIHSKKLINRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSK-G 183 Query: 172 TPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPP 231 T Y++PE +S Q Y G D+++ G+IL +L +T + + Sbjct: 184 TLRYMSPEQISSQDY-GKEVDLYALGLILAELLH----VCDTAFETSKFFTDLRDGIISD 238 Query: 232 WFSAEVKFLIHRILDPNPKTRIQIQGIKK 260 F + K L+ ++L P+ R I + Sbjct: 239 IFDKKEKTLLQKLLSKKPEDRPNTSEILR 267 >2BUJ-A nrPDB Length = 317 Score = 190 bits (484), Expect = 7e-49, Method: Composition-based stats. Identities = 66/272 (24%), Positives = 111/272 (40%), Gaps = 27/272 (9%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 Y + +GEG F+ V G A+K + + + ++ +RE + ++ HPN Sbjct: 31 YLFIQKLGEGGFSYVDLVEGLHDGHFYALKRI---LCHEQQDREEAQREADMHRLFNHPN 87 Query: 71 IVRLYEVLASPS----KIYIVLEFVTGGELFDRIVH----KGRLEESESRKYFQQLVDAV 122 I+RL + +++L F G L++ I L E + + + Sbjct: 88 ILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFLTEDQILWLLLGICRGL 147 Query: 123 AHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGL---SALPQEGVELLRTT------CGTP 173 H KG HRDLKP N+LL G + D G + + EG T T Sbjct: 148 EAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALTLQDWAAQRCTI 207 Query: 174 NYVAPEVLSGQGYD--GSAADIWSCGVILFVILAGYLP----FSETDLPGLYRKINAAEF 227 +Y APE+ S Q + D+WS G +L+ ++ G P F + D L + N Sbjct: 208 SYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPYDMVFQKGDSVALAVQ-NQLSI 266 Query: 228 SCPPWFSAEVKFLIHRILDPNPKTRIQIQGIK 259 P S+ + L++ ++ +P R I + Sbjct: 267 PQSPRHSSALWQLLNSMMTVDPHQRPHIPLLL 298 >5LPZ-A nrPDB Length = 332 Score = 190 bits (484), Expect = 9e-49, Method: Composition-based stats. Identities = 73/298 (24%), Positives = 119/298 (39%), Gaps = 33/298 (11%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 + IG G F V A D G VAIK + + +R + E+ + ++H N Sbjct: 19 FHNDSLIGSGGFGDVYKAILKD-GSAVAIKKLIHVSGQGDR---EFMAEMETIGKIKHRN 74 Query: 71 IVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGR----LEESESRKYFQQLVDAVAHCH 126 +V L + +V EF+ G L D + + L S RK +A H Sbjct: 75 LVPLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLH 134 Query: 127 ---CKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQ--EGVELLRTTCGTPNYVAPEVL 181 + HRD+K N+LLD N +VSDFG++ L + + T GTP YV PE Sbjct: 135 HNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYY 194 Query: 182 SGQGYDGSAADIWSCGVILFVILAGYLP-----FSETDLPGLYRKINAAEFSCPPWFSAE 236 + D++S GV+L +L G P F + +L G ++ A+ F E Sbjct: 195 Q-SFRCSTKGDVYSYGVVLLELLTGKRPTDSPDFGDNNLVGWVKQ--HAKLRISDVFDPE 251 Query: 237 VKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEVNLDDIRAVFDGIEGS 294 ++ +P I + + ++ + R + + A+F I+ Sbjct: 252 -------LMKEDPALEI---ELLQH--LKVAVACLDDRAWRRPTMVQVMAMFKEIQAG 297 >6J5U-C nrPDB Length = 426 Score = 190 bits (483), Expect = 9e-49, Method: Composition-based stats. Identities = 65/285 (22%), Positives = 110/285 (38%), Gaps = 41/285 (14%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDT---------GDNVAIKIMAKSTILKNRMVDQIKREI 60 + +GEG F V T G VA+K + + + E+ Sbjct: 85 NFRQDNLLGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQLKPEGF---QGHKEWLTEV 141 Query: 61 SIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKG--RLEESESRKYFQQL 118 + + + HPN+V L A +V EF+ G L + + +G L + K Sbjct: 142 NYLGQLSHPNLVLLVGYCAEGENRLLVYEFMPKGSLENHLFRRGAQPLTWAIRMKVAVGA 201 Query: 119 VDAVAHCHCKG--VYHRDLKPENLLLDTNGNLKVSDFGLSALPQ--EGVELLRTTCGTPN 174 + H V +RD K N+LLD + N K+SDFGL+ + + GT Sbjct: 202 AKGLTFLHEAKSQVIYRDFKAANILLDADFNAKLSDFGLAKAGPTGDNTHVSTKVIGTHG 261 Query: 175 YVAPEVLSGQGYDGSAADIWSCGVILFVILAGY------------------LPFSETDLP 216 Y APE ++ G + +D++S GV+L +++G P+ D Sbjct: 262 YAAPEYVA-TGRLTAKSDVYSFGVVLLELISGRRAMDNSNGGNEYSLVDWATPYLG-DKR 319 Query: 217 GLYRKINAAEF--SCPPWFSAEVKFLIHRILDPNPKTRIQIQGIK 259 L+R I + P + L + L+P+ K R ++ + Sbjct: 320 KLFR-IMDTKLGGQYPQKGAFTAANLALQCLNPDAKLRPKMSEVL 363 >5LPV-A nrPDB Length = 296 Score = 190 bits (483), Expect = 1e-48, Method: Composition-based stats. Identities = 73/297 (24%), Positives = 119/297 (40%), Gaps = 33/297 (11%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 + IG G F V A D G VAIK + + +R + E+ + ++H N Sbjct: 19 FHNDSLIGSGGFGDVYKAILKD-GSAVAIKKLIHVSGQGDR---EFMAEMETIGKIKHRN 74 Query: 71 IVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGR----LEESESRKYFQQLVDAVAHCH 126 +V L + +V EF+ G L D + + L S RK +A H Sbjct: 75 LVPLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLH 134 Query: 127 ---CKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQ--EGVELLRTTCGTPNYVAPEVL 181 + HRD+K N+LLD N +VSDFG++ L + + T GTP YV PE Sbjct: 135 HNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYY 194 Query: 182 SGQGYDGSAADIWSCGVILFVILAGYLP-----FSETDLPGLYRKINAAEFSCPPWFSAE 236 + D++S GV+L +L G P F + +L G ++ A+ F E Sbjct: 195 Q-SFRCSTKGDVYSYGVVLLELLTGKRPTDSPDFGDNNLVGWVKQ--HAKLRISDVFDPE 251 Query: 237 VKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEVNLDDIRAVFDGIEG 293 ++ +P I + + ++ + R + + A+F I+ Sbjct: 252 -------LMKEDPALEI---ELLQH--LKVAVACLDDRAWRRPTMVQVMAMFKEIQA 296 >6O6Q-A nrPDB Length = 335 Score = 189 bits (481), Expect = 2e-48, Method: Composition-based stats. Identities = 64/307 (20%), Positives = 122/307 (39%), Gaps = 51/307 (16%) Query: 1 MTKKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREI 60 + K YE+ R +G G +++V + + + V IK++ +IKREI Sbjct: 33 LNIKWNPQENYEILRKLGRGKYSEVFLGIDLEKREKVVIKVLKPVK------RKKIKREI 86 Query: 61 SIMKIV-RHPNIVRLYEVLASPSK--IYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQ 117 SI+K + PNI+ + +V+ P ++ E + + + + R Y + Sbjct: 87 SILKNLVDGPNIIAMLDVVREPQSKTPGLIFEHINNIDFRSL---YPTFTDYDIRFYMYE 143 Query: 118 LVDAVAHCHCKGVYHRDLKPENLLLDTNGN-LKVSDFGLSALPQEGVELLRTTCGTPNYV 176 L+ A+ + H G+ HRD+KP N+++D + L++ D+GL+ G E + + Sbjct: 144 LLKALDYSHSMGIMHRDVKPHNVMIDHDKKLLRLIDWGLAEYYHPGTEY-NVRVASRYFK 202 Query: 177 APEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSE--TDLPGLYRKINA---------- 224 PE+L + D+WS G +L ++ PF ++ L + + Sbjct: 203 GPELLVDYRLYDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQLVQIVRVLGSKNFKKYL 262 Query: 225 --------------AEFSCPPW-----------FSAEVKFLIHRILDPNPKTRIQIQGIK 259 ++ W S E LI R+L + + R+ + Sbjct: 263 EKYNISLGEEYEDIGYYNKRQWVRFMNENNKDLVSQEFLDLIDRLLRYDHQERLTAKEAM 322 Query: 260 KDPWFRL 266 K +F Sbjct: 323 KHAYFDP 329 >4G3E-A nrPDB Length = 352 Score = 189 bits (480), Expect = 2e-48, Method: Composition-based stats. Identities = 69/278 (24%), Positives = 114/278 (41%), Gaps = 28/278 (10%) Query: 1 MTKKMRRVGKYEVGRTI---------GEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNR 51 +T+K++ V YE + G G+F +V ++ TG A+K + Sbjct: 58 LTEKLKPVD-YEYREEVHWMTHQPRVGRGSFGEVHRMKDKQTGFQCAVKKVRLEVFR--- 113 Query: 52 MVDQIKREISIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESES 111 E+ + P IV LY + + I +E + GG L I G L E + Sbjct: 114 -----VEELVACAGLSSPRIVPLYGAVREGPWVNIFMELLEGGSLGQLIKQMGCLPEDRA 168 Query: 112 RKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNG-NLKVSDFGLSALPQE---GVELLR 167 Y Q ++ + + H + + H D+K +N+LL ++G + DFG + Q G LL Sbjct: 169 LYYLGQALEGLEYLHTRRILHGDVKADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLT 228 Query: 168 T--TCGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKI--- 222 GT ++APEV+ G+ D DIWS ++ +L G P+++ L KI Sbjct: 229 GDYIPGTETHMAPEVVMGKPCDA-KVDIWSSCCMMLHMLNGCHPWTQYFRGPLCLKIASE 287 Query: 223 NAAEFSCPPWFSAEVKFLIHRILDPNPKTRIQIQGIKK 260 PP + I L P R +++ Sbjct: 288 PPPIREIPPSCAPLTAQAIQEGLRKEPVHRASAMELRR 325 >2WO6-A nrPDB Length = 382 Score = 188 bits (478), Expect = 4e-48, Method: Composition-based stats. Identities = 70/268 (26%), Positives = 115/268 (42%), Gaps = 32/268 (11%) Query: 8 VGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR 67 + +YE+ IG+G+F +V A + + VAIKI+ K ++Q + E+ +++++ Sbjct: 53 MDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKN----KKAFLNQAQIEVRLLELMN 108 Query: 68 -HP-----NIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKG--RLEESESRKYFQQLV 119 H IV L + + +V E ++ L+D + + + + +RK+ QQ+ Sbjct: 109 KHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSY-NLYDLLRNTNFRGVSLNLTRKFAQQMC 167 Query: 120 DAVAHCHCK--GVYHRDLKPENLLLD--TNGNLKVSDFGLSALPQEGVELLRTTCGTPNY 175 A+ + H DLKPEN+LL +K+ DFG S + + + Y Sbjct: 168 TALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQL---GQRIYQYIQSRFY 224 Query: 176 VAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSA 235 +PEVL G YD A D+WS G IL + G FS + KI P Sbjct: 225 RSPEVLLGMPYD-LAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHI-- 281 Query: 236 EVKFLIHRILDPNPKTRIQIQGIKKDPW 263 LD PK R + + W Sbjct: 282 ---------LDQAPKARKFFEKLPDGTW 300 Score = 39.5 bits (91), Expect = 0.003, Method: Composition-based stats. Identities = 13/34 (38%), Positives = 18/34 (52%) Query: 237 VKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVP 270 K LI R+LD +PKTRIQ + +F+ Sbjct: 349 FKDLILRMLDYDPKTRIQPYYALQHSFFKKTADE 382 >3UIU-A nrPDB Length = 306 Score = 188 bits (477), Expect = 5e-48, Method: Composition-based stats. Identities = 62/282 (21%), Positives = 113/282 (40%), Gaps = 44/282 (15%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 ++ IG G F +V A++ G I+ + + ++ +RE+ + + H Sbjct: 13 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIRRVKYNN-------EKAEREVKALAKLDHV 65 Query: 70 NIVRLYEVL-----------------------------ASPSKIYIVLEFVTGGELFDRI 100 NIV + ++I +EF G L I Sbjct: 66 NIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWI 125 Query: 101 VHK--GRLEESESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSAL 158 + +L++ + + F+Q+ V + H K + HRDLKP N+ L +K+ DFGL Sbjct: 126 EKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTS 185 Query: 159 PQEGVELLRTTCGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGL 218 + + R+ GT Y++PE +S Q Y G D+++ G+IL +L +T Sbjct: 186 LKNDGKRTRSK-GTLRYMSPEQISSQDY-GKEVDLYALGLILAELLH----VCDTAFETS 239 Query: 219 YRKINAAEFSCPPWFSAEVKFLIHRILDPNPKTRIQIQGIKK 260 + + F + K L+ ++L P+ R I + Sbjct: 240 KFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILR 281 >5IKW-A nrPDB Length = 310 Score = 187 bits (474), Expect = 1e-47, Method: Composition-based stats. Identities = 79/305 (25%), Positives = 138/305 (45%), Gaps = 34/305 (11%) Query: 12 EVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR-HPN 70 + ++ EG F+ V R T G A+K M + + ++ KREI+IMK + H N Sbjct: 17 TLEESLAEGGFSTVFLVR-THGGIRCALKRMYVNNMPD---LNVCKREITIMKELSGHKN 72 Query: 71 IVRLYEV----LASPS-KIYIVLEFVTGGELFDRIVHK--GRLEESESRKYFQQLVDAVA 123 IV + ++ ++ I++E+ G++ +++ K E E + F +AVA Sbjct: 73 IVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVA 132 Query: 124 HCHCKG--VYHRDLKPENLLLDTNGNLKVSDFGLSALP-----QEGVELLRTTCG---TP 173 H + HRDLK EN+LL+ GN + DFG + ++GV ++ T Sbjct: 133 RLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTL 192 Query: 174 NYVAPEVLS--GQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPP 231 +Y APE+++ G + ADIW+ G +L+ + LPF E+ + I F+ P Sbjct: 193 SYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPFGESQVA-----ICDGNFTIPD 247 Query: 232 --WFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEVNLDDIRAVFD 289 +S + LI +L+P+P+ R I + +F + N A+ + Sbjct: 248 NSRYSRNIHCLIRFMLEPDPEHRPDIFQV---SYFAFKFAAADCPVSNINNSSIPSALPE 304 Query: 290 GIEGS 294 + S Sbjct: 305 PMTAS 309 >3Q4U-A nrPDB Length = 301 Score = 185 bits (470), Expect = 3e-47, Method: Composition-based stats. Identities = 65/296 (21%), Positives = 114/296 (38%), Gaps = 54/296 (18%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMK--IVR 67 + +G+G + +V + G+NVA+KI + +R RE + ++R Sbjct: 9 DITLLECVGKGRYGEVWRG--SWQGENVAVKIFS------SRDEKSWFRETELYNTVMLR 60 Query: 68 HPNIVRLYEVLASPSK----IYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVA 123 H NI+ + ++++ + G L+D + L+ + + +A Sbjct: 61 HENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLT-TLDTVSCLRIVLSIASGLA 119 Query: 124 HCH--------CKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRT----TCG 171 H H + HRDLK +N+L+ NG ++D GL+ + + L G Sbjct: 120 HLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVG 179 Query: 172 TPNYVAPEVLSGQ----GYDGSA-ADIWSCGVILFVILAG----------YLPFSE---- 212 T Y+APEVL +D DIW+ G++L+ + PF + Sbjct: 180 TKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPN 239 Query: 213 TDLPGLYRK---INAAEFSCP-PWFSA----EVKFLIHRILDPNPKTRIQIQGIKK 260 RK ++ + P WFS + L+ NP R+ IKK Sbjct: 240 DPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKK 295 >2RIO-A nrPDB Length = 434 Score = 184 bits (468), Expect = 6e-47, Method: Composition-based stats. Identities = 75/308 (24%), Positives = 116/308 (37%), Gaps = 49/308 (15%) Query: 14 GRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR-HPNIV 72 + +G G+ V F + + G VA+K M D EI ++ HPN++ Sbjct: 20 EKILGYGSSGTVVF-QGSFQGRPVAVKRMLID------FCDIALMEIKLLTESDDHPNVI 72 Query: 73 RLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESE-------SRKYFQQLVDAVAHC 125 R Y + +YI LE L D + K +E+ +Q+ VAH Sbjct: 73 RYYCSETTDRFLYIALELCNL-NLQDLVESKNVSDENLKLQKEYNPISLLRQIASGVAHL 131 Query: 126 HCKGVYHRDLKPENLLLD-------------TNGNLKVSDFGLSALPQEGVELLRT---- 168 H + HRDLKP+N+L+ N + +SDFGL G RT Sbjct: 132 HSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRTNLNN 191 Query: 169 TCGTPNYVAPEVLSG------QGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRK 221 GT + APE+L + + DI+S G + + IL+ G PF + Sbjct: 192 PSGTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPFGDKYSRE--SN 249 Query: 222 INAAEFSCPP-------WFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAR 274 I FS AE LI +++D +P R + + P F + Sbjct: 250 IIRGIFSLDEMKCLHDRSLIAEATDLISQMIDHDPLKRPTAMKVLRHPLFWPKSKKLEFL 309 Query: 275 EEEEVNLD 282 + L+ Sbjct: 310 LKVSDRLE 317 >3MY0-A nrPDB Length = 305 Score = 183 bits (466), Expect = 1e-46, Method: Composition-based stats. Identities = 64/294 (21%), Positives = 114/294 (38%), Gaps = 56/294 (19%) Query: 13 VGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMK--IVRHPN 70 + +G+G + +V G++VA+KI + +R RE I ++RH N Sbjct: 12 LVECVGKGRYGEVWRG--LWHGESVAVKIFS------SRDEQSWFRETEIYNTVLLRHDN 63 Query: 71 IVRLYEVLASP----SKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCH 126 I+ + ++++++ + G L+D + + LE + + +AH H Sbjct: 64 ILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQ-TLEPHLALRLAVSAACGLAHLH 122 Query: 127 --------CKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELL----RTTCGTPN 174 + HRD K N+L+ +N ++D GL+ + +G + L GT Sbjct: 123 VEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKR 182 Query: 175 YVAPEVLSGQGYD-----GSAADIWSCGVILFVILAG----------YLPFSE----TDL 215 Y+APEVL Q DIW+ G++L+ I PF + Sbjct: 183 YMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPS 242 Query: 216 PGLYRKINAAEFSCP---------PWFSAEVKFLIHRILDPNPKTRIQIQGIKK 260 +K+ + P P S + ++ PNP R+ IKK Sbjct: 243 FEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQ-MMRECWYPNPSARLTALRIKK 295 >4JLC-A nrPDB Length = 657 Score = 181 bits (461), Expect = 4e-46, Method: Composition-based stats. Identities = 61/236 (25%), Positives = 108/236 (45%), Gaps = 23/236 (9%) Query: 13 VGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIV 72 + +G+G A V R+ TGD A+K+ + L+ V RE ++K + H NIV Sbjct: 12 LSDILGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQ--MREFEVLKKLNHKNIV 69 Query: 73 RLYEVLASPSKIY--IVLEFVTGGELFDRIVHKGR---LEESESRKYFQQLVDAVAHCHC 127 +L+ + + + +++EF G L+ + L ESE + +V + H Sbjct: 70 KLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE 129 Query: 128 KGVYHRDLKPENLL--LDTNGN--LKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLS- 182 G+ HRD+KP N++ + +G K++DFG + ++ + + + GT Y+ P++ Sbjct: 130 NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFV-SLYGTEEYLHPDMYER 188 Query: 183 ------GQGYDGSAADIWSCGVILFVILAGYLPFSETDLP----GLYRKINAAEFS 228 Q G+ D+WS GV + G LPF + P + KI + S Sbjct: 189 AVLRKDHQKKYGATVDLWSVGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS 244 >5L2Q-C nrPDB Length = 320 Score = 181 bits (460), Expect = 4e-46, Method: Composition-based stats. Identities = 74/302 (24%), Positives = 133/302 (44%), Gaps = 48/302 (15%) Query: 4 KMRRVGKYEVGRTIGEGTFAKV-----KFARNTDTGDNVAIKIMAKSTILKNRMVDQIKR 58 +R G + +G +G + V AR T D +KI+ + Q +R Sbjct: 9 NAKRAGPFILGPRLGN---SPVPSIVQCLARKDGTDDFYQLKILTLEERGDQGIESQEER 65 Query: 59 --------EISIMKIVR-HPNIVRLYEVLAS------------------PSKIYIVLEFV 91 E S++ ++ +V + + +I +VL+ + Sbjct: 66 QGKMLLHTEYSLLSLLHTQDGVVHHHGLFQDRTCEIVEDTESSRMVKKMKKRICLVLDCL 125 Query: 92 TGGE----------LFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDLKPENLL 141 + L ++ + RL E E+ F +V V H K + HRDLK N++ Sbjct: 126 CAHDFSDKTADLINLQHYVIKEKRLSERETVVIFYDVVRVVEALHQKNIVHRDLKLGNMV 185 Query: 142 LDTNGN-LKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSAADIWSCGVIL 200 L+ + + +++F L +LL+ G+P Y++P+VLSG+ Y G +D+W+ GV+L Sbjct: 186 LNKRTHRITITNFCLGKHLVSEGDLLKDQRGSPAYISPDVLSGRPYRGKPSDMWALGVVL 245 Query: 201 FVILAGYLPFSETDLPGLYRKINAAEFSCPP--WFSAEVKFLIHRILDPNPKTRIQIQGI 258 F +L G PF ++ L+RKI AAE++ P S LI ++L +P+ R+ + Sbjct: 246 FTMLYGQFPFYDSIPQELFRKIKAAEYTIPEDGRVSENTVCLIRKLLVLDPQQRLAAADV 305 Query: 259 KK 260 + Sbjct: 306 LE 307 >4EUU-A nrPDB Length = 319 Score = 181 bits (460), Expect = 4e-46, Method: Composition-based stats. Identities = 61/236 (25%), Positives = 108/236 (45%), Gaps = 23/236 (9%) Query: 13 VGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIV 72 + +G+G A V R+ TGD AIK+ + L+ V RE ++K + H NIV Sbjct: 13 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHKNIV 70 Query: 73 RLYEVLASPSKIY--IVLEFVTGGELFDRIVHKGR---LEESESRKYFQQLVDAVAHCHC 127 +L+ + + + +++EF G L+ + L ESE + +V + H Sbjct: 71 KLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE 130 Query: 128 KGVYHRDLKPENLL--LDTNGN--LKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLS- 182 G+ HR++KP N++ + +G K++DFG + ++ + + + GT Y+ P++ Sbjct: 131 NGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFV-SLYGTEEYLHPDMYER 189 Query: 183 ------GQGYDGSAADIWSCGVILFVILAGYLPFSETDLP----GLYRKINAAEFS 228 Q G+ D+WS GV + G LPF + P + KI + S Sbjct: 190 AVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS 245 >5AR8-A nrPDB Length = 326 Score = 181 bits (459), Expect = 6e-46, Method: Composition-based stats. Identities = 60/267 (22%), Positives = 100/267 (37%), Gaps = 21/267 (7%) Query: 14 GRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVR 73 R + G V AR+ D VA+K + T L + + RE I+ R I+ Sbjct: 37 LRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILP 96 Query: 74 LYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLE---ESESRKYFQQLVDAVAHCHCK-- 128 + + P + IV E++ G L + + K + ++ V + H Sbjct: 97 ILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTP 156 Query: 129 GVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTC-----GTPNYVAPEVLS- 182 + H DLK +N+LLD ++K++DFGLS + R++ GT Y+ PE Sbjct: 157 PLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEP 216 Query: 183 -GQGYDGSAADIWSCGVILFVILAGYLPFSETDLP-GLYRKINAAEFS------CPPWFS 234 + DI+S VI + +L+ PF + P + ++ P Sbjct: 217 GQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIP 276 Query: 235 AEVK--FLIHRILDPNPKTRIQIQGIK 259 + LI NP R Sbjct: 277 HRARMISLIESGWAQNPDERPSFLKCL 303 >5VC6-A nrPDB Length = 289 Score = 181 bits (459), Expect = 7e-46, Method: Composition-based stats. Identities = 61/286 (21%), Positives = 104/286 (36%), Gaps = 35/286 (12%) Query: 2 TKKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREIS 61 + K R ++ IG G F V G AIK +K + + RE+ Sbjct: 4 SMKSRYTTEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKR-SKKPLAGSVDEQNALREVY 62 Query: 62 IMKIV-RHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGR----LEESESRKYFQ 116 ++ +H ++VR + A + I E+ GG L D I R +E+E + Sbjct: 63 AHAVLGQHSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLL 122 Query: 117 QLVDAVAHCHCKGVYHRDLKPENLLLDTNGNL-------------------KVSDFG-LS 156 Q+ + + H + H D+KP N+ + K+ D G ++ Sbjct: 123 QVGRGLRYIHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVT 182 Query: 157 ALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLP 216 + VE G ++A EVL ADI++ + + V AG P Sbjct: 183 RISSPQVEE-----GDSRFLANEVLQENYTHLPKADIFALALTV-VCAAGAEPLPRNGDQ 236 Query: 217 GLYRKINAAEFS-CPPWFSAEVKFLIHRILDPNPKTRIQIQGIKKD 261 + +I P S E L+ ++ P+P+ R + K Sbjct: 237 --WHEIRQGRLPRIPQVLSQEFTELLKVMIHPDPERRPSAMALVKH 280 >5UNP-A nrPDB Length = 369 Score = 180 bits (457), Expect = 1e-45, Method: Composition-based stats. Identities = 71/328 (21%), Positives = 123/328 (37%), Gaps = 81/328 (24%) Query: 9 GKYEVGRTIGEGTFAKVKFAR-NTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR 67 +YE+ T+GEGTF +V + G VA+KI+ K + + EI++++ + Sbjct: 34 ERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYK----EAARLEINVLEKIN 89 Query: 68 -----HPNI-VRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEES--ESRKYFQQLV 119 + N+ V++++ + I E + G FD + L + R QL Sbjct: 90 EKDPDNKNLCVQMFDWFDYHGHMCISFELL-GLSTFDFLKDNNYLPYPIHQVRHMAFQLC 148 Query: 120 DAVAHCHCKGVYHRDLKPENLL-LDTNGN------------------LKVSDFGLSALPQ 160 AV H + H DLKPEN+L ++++ ++V DFG + Sbjct: 149 QAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDH 208 Query: 161 EGVELLRTTCGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPG--- 217 E T T +Y APEV+ G+ D+WS G I+F G+ F D Sbjct: 209 EHHS---TIVSTRHYRAPEVILELGW-SQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLA 264 Query: 218 ------------LYRKINAAEF-----------------------SCPPWFSAEVK---- 238 + RK ++ + ++E + Sbjct: 265 MMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQ 324 Query: 239 --FLIHRILDPNPKTRIQIQGIKKDPWF 264 LI +L+ P R+ + + P+F Sbjct: 325 LFDLIESMLEYEPAKRLTLGEALQHPFF 352 >4EUT-A nrPDB Length = 396 Score = 180 bits (456), Expect = 1e-45, Method: Composition-based stats. Identities = 61/236 (25%), Positives = 108/236 (45%), Gaps = 23/236 (9%) Query: 13 VGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIV 72 + +G+G A V R+ TGD AIK+ + L+ V RE ++K + H NIV Sbjct: 13 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHKNIV 70 Query: 73 RLYEVLASPSKIY--IVLEFVTGGELFDRIVHKGR---LEESESRKYFQQLVDAVAHCHC 127 +L+ + + + +++EF G L+ + L ESE + +V + H Sbjct: 71 KLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE 130 Query: 128 KGVYHRDLKPENLL--LDTNGN--LKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLS- 182 G+ HR++KP N++ + +G K++DFG + ++ + + + GT Y+ P++ Sbjct: 131 NGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFV-SLYGTEEYLHPDMYER 189 Query: 183 ------GQGYDGSAADIWSCGVILFVILAGYLPFSETDLP----GLYRKINAAEFS 228 Q G+ D+WS GV + G LPF + P + KI + S Sbjct: 190 AVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS 245 >5XVU-A nrPDB Length = 332 Score = 179 bits (454), Expect = 2e-45, Method: Composition-based stats. Identities = 70/304 (23%), Positives = 125/304 (41%), Gaps = 52/304 (17%) Query: 4 KMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIM 63 + + +YE+ + IG G +++V +T+ A +LK +IKREI I+ Sbjct: 26 QWNKPNRYEIMKKIGRGKYSEVFNGYDTECNRPCA------IKVLKPVKKKKIKREIKIL 79 Query: 64 KIVRH-PNIVRLYEVLASP--SKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVD 120 + + PNI++L +++ P ++ E++ D + + + R Y Q++ Sbjct: 80 QNLNGGPNIIKLLDIVKDPVTKTPSLIFEYINN---IDFKTLYPKFTDKDIRYYIYQILK 136 Query: 121 AVAHCHCKGVYHRDLKPENLLLD-TNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPE 179 A+ +CH +G+ HRD+KP N+++D N +++ +GL+ G E + Y PE Sbjct: 137 ALDYCHSQGIMHRDVKPHNIMIDHENRQIRLISWGLAEFYHPGQEY-NVRVASRYYKGPE 195 Query: 180 VLSGQGYDGSAADIWSCGVILFVILAGYLP-FSETDLPGLYRKINA-------------- 224 +L + DIWS G +L ++ P F D KI Sbjct: 196 LLIDLQLYDYSLDIWSLGCMLAGMIFKKEPFFCGHDNYDQLVKIAKVLGTEDLHAYLKKY 255 Query: 225 ------------AEFSCPPW-----------FSAEVKFLIHRILDPNPKTRIQIQGIKKD 261 E+ PW EV LI ++L + RI + + Sbjct: 256 NIKLKPHYLNILGEYERKPWSHFLTQSNIDIAKDEVIDLIDKMLIYDHAKRIAPKEAMEH 315 Query: 262 PWFR 265 P+FR Sbjct: 316 PYFR 319 >3UIM-A nrPDB Length = 326 Score = 178 bits (451), Expect = 5e-45, Method: Composition-based stats. Identities = 53/211 (25%), Positives = 92/211 (43%), Gaps = 12/211 (5%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 + +G G F KV R G VA+K + + + Q + E+ ++ + H Sbjct: 30 DNFSNKNILGRGGFGKVYKGR-LADGTLVAVKRLKEERTQGGEL--QFQTEVEMISMAVH 86 Query: 69 PNIVRLYEVLASPSKIYIVLEFVTGGE----LFDRIVHKGRLEESESRKYFQQLVDAVAH 124 N++RL +P++ +V ++ G L +R + L+ + ++ +A+ Sbjct: 87 RNLLRLRGFCMTPTERLLVYPYMANGSVASCLRERPESQPPLDWPKRQRIALGSARGLAY 146 Query: 125 CHCK---GVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTC-GTPNYVAPEV 180 H + HRD+K N+LLD V DFGL+ L + T GT ++APE Sbjct: 147 LHDHCDPKIIHRDVKAANILLDEEFEAVVGDFGLAKLMDYKDTHVTTAVRGTIGHIAPEY 206 Query: 181 LSGQGYDGSAADIWSCGVILFVILAGYLPFS 211 LS G D++ GV+L ++ G F Sbjct: 207 LS-TGKSSEKTDVFGYGVMLLELITGQRAFD 236 >2PVN-A nrPDB Length = 352 Score = 177 bits (450), Expect = 7e-45, Method: Composition-based stats. Identities = 60/307 (19%), Positives = 112/307 (36%), Gaps = 50/307 (16%) Query: 1 MTKKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREI 60 +T + YEV R +G G +++V N + + + + + Sbjct: 44 LTVQWGEQDDYEVVRKVGRGKYSEVFEGINVNNNE-----KCIIKILKPVKKKKIKREIK 98 Query: 61 SIMKIVRHPNIVRLYEVL--ASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQL 118 + + PNIV+L +++ ++ E+V D V L + + R Y +L Sbjct: 99 ILQNLCGGPNIVKLLDIVRDQHSKTPSLIFEYVNN---TDFKVLYPTLTDYDIRYYIYEL 155 Query: 119 VDAVAHCHCKGVYHRDLKPENLLLDTNGN-LKVSDFGLSALPQEGVELLRTTCGTPNYVA 177 + A+ +CH +G+ HRD+KP N+++D L++ D+GL+ G E + + Sbjct: 156 LKALDYCHSQGIMHRDVKPHNVMIDHELRKLRLIDWGLAEFYHPGKEY-NVRVASRYFKG 214 Query: 178 PEVLSGQGYDGSAADIWSCGVILFVILAGYLP-FSETDLPGLYRKINA------------ 224 PE+L + D+WS G + ++ P F D KI Sbjct: 215 PELLVDLQDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKIAKVLGTDGLNAYLN 274 Query: 225 --------------AEFSCPPW-----------FSAEVKFLIHRILDPNPKTRIQIQGIK 259 S PW S E + ++L + + R+ Sbjct: 275 KYRIELDPQLEALVGRHSRKPWLKFMNADNQHLVSPEAIDFLDKLLRYDHQERLTALEAM 334 Query: 260 KDPWFRL 266 P+F+ Sbjct: 335 THPYFQQ 341 >4PL5-B nrPDB Length = 435 Score = 177 bits (450), Expect = 7e-45, Method: Composition-based stats. Identities = 63/266 (23%), Positives = 106/266 (39%), Gaps = 26/266 (9%) Query: 16 TIGEGTFAK-VKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR-HPNIVR 73 +G G V +VA+K + RE+ +++ HPN++R Sbjct: 34 VLGHGAEGTIVYKG--MFDNRDVAVKRILPECFS------FADREVQLLRESDEHPNVIR 85 Query: 74 LYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEES-ESRKYFQQLVDAVAHCHCKGVYH 132 + YI +E L + + K E Q +AH H + H Sbjct: 86 YFCTEKDRQFQYIAIELCAA-TLQEYVEQKDFAHLGLEPITLLHQTTSGLAHLHSLNIVH 144 Query: 133 RDLKPENLLL---DTNGNLK--VSDFGLSALP---QEGVELLRTTCGTPNYVAPEVLSGQ 184 RDLKP N+LL + +G +K +SDFGL + GT ++APE+LS Sbjct: 145 RDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSED 204 Query: 185 GYD--GSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAAEFSC---PPWFSAEVK 238 D DI+S G + + +++ GY PF ++ + A C + Sbjct: 205 CKDNPTYTVDIFSAGCVFYYVISEGYHPFGKSLQRQANILLGACNLDCFHSDKHEDVIAR 264 Query: 239 FLIHRILDPNPKTRIQIQGIKKDPWF 264 LI +++ +P+ R + + K P+F Sbjct: 265 ELIEKMIAMDPQQRPSAKHVLKHPFF 290 >3MDY-A nrPDB Length = 337 Score = 177 bits (449), Expect = 9e-45, Method: Composition-based stats. Identities = 65/296 (21%), Positives = 119/296 (40%), Gaps = 54/296 (18%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMK--IVR 67 + ++ + IG+G + +V + G+ VA+K+ RE I + ++R Sbjct: 38 QIQMVKQIGKGRYGEVWMGKWR--GEKVAVKVFF------TTEEASWFRETEIYQTVLMR 89 Query: 68 HPNIVRLYEVLASPS----KIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVA 123 H NI+ + ++Y++ ++ G L+D + L+ K V + Sbjct: 90 HENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKST-TLDAKSMLKLAYSSVSGLC 148 Query: 124 HCHC--------KGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELL----RTTCG 171 H H + HRDLK +N+L+ NG ++D GL+ + T G Sbjct: 149 HLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVG 208 Query: 172 TPNYVAPEVL---SGQGYDGSA--ADIWSCGVILFV----ILAG------YLPF-----S 211 T Y+ PEVL + + S AD++S G+IL+ ++G LP+ S Sbjct: 209 TKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLVPS 268 Query: 212 ETDLPGLYRK--INAAEFSCPPWFSAE-----VKFLIHRILDPNPKTRIQIQGIKK 260 + + I S P +S++ + L+ NP +R+ +KK Sbjct: 269 DPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKK 324 >4CRL-A nrPDB Length = 406 Score = 177 bits (449), Expect = 1e-44, Method: Composition-based stats. Identities = 71/328 (21%), Positives = 130/328 (39%), Gaps = 74/328 (22%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDN--VAIKIMAKSTILKNRMVDQIKREISIMKIVR 67 +YE + G GT+ V A+ D D+ A+K + + I REI++++ ++ Sbjct: 24 EYEGCKV-GRGTYGHVYKAKRKDGKDDKDYALKQIEGTGI-----SMSACREIALLRELK 77 Query: 68 HPNIVRLYEVLAS--PSKIYIVLEFVTGGELFDRIVHKG---------RLEESESRKYFQ 116 HPN++ L +V S K++++ ++ +L+ I +L + Sbjct: 78 HPNVISLQKVFLSHADRKVWLLFDYAEH-DLWHIIKFHRASKANKKPVQLPRGMVKSLLY 136 Query: 117 QLVDAVAHCHCKGVYHRDLKPENLLLD----TNGNLKVSDFGLSALPQEGVELLRTT--- 169 Q++D + + H V HRDLKP N+L+ G +K++D G + L ++ L Sbjct: 137 QILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPV 196 Query: 170 CGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYL-------------PFSETDLP 216 T Y APE+L G + A DIW+ G I +L P+ L Sbjct: 197 VVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLD 256 Query: 217 GLYRKI------NAAEFSCPPWFSAEVKF----------------------------LIH 242 ++ + + + P S +K L+ Sbjct: 257 RIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQ 316 Query: 243 RILDPNPKTRIQIQGIKKDPWFRLNYVP 270 ++L +P RI + +DP+F + +P Sbjct: 317 KLLTMDPIKRITSEQAMQDPYFLEDPLP 344 >6O8B-A nrPDB Length = 665 Score = 177 bits (449), Expect = 1e-44, Method: Composition-based stats. Identities = 61/236 (25%), Positives = 107/236 (45%), Gaps = 23/236 (9%) Query: 13 VGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIV 72 + +G+G A V R+ TGD AIK+ + L+ V RE ++K + H NIV Sbjct: 19 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHKNIV 76 Query: 73 RLYEVLASPSKIY--IVLEFVTGGELFDRIVHKGR---LEESESRKYFQQLVDAVAHCHC 127 +L+ + + + +++EF G L+ + L ESE + +V + H Sbjct: 77 KLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE 136 Query: 128 KGVYHRDLKPENLL--LDTNGN--LKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLS- 182 G+ HR++KP N++ + +G K++DFG + ++ + + GT Y+ P++ Sbjct: 137 NGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFV-ELYGTEEYLHPDMYER 195 Query: 183 ------GQGYDGSAADIWSCGVILFVILAGYLPFSETDLP----GLYRKINAAEFS 228 Q G+ D+WS GV + G LPF + P + KI + S Sbjct: 196 AVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS 251 >6NT9-A nrPDB Length = 742 Score = 176 bits (448), Expect = 1e-44, Method: Composition-based stats. Identities = 61/236 (25%), Positives = 108/236 (45%), Gaps = 23/236 (9%) Query: 13 VGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIV 72 + +G+G A V R+ TGD AIK+ + L+ V RE ++K + H NIV Sbjct: 11 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHKNIV 68 Query: 73 RLYEVLASPSKIY--IVLEFVTGGELFDRIVHKGR---LEESESRKYFQQLVDAVAHCHC 127 +L+ + + + +++EF G L+ + L ESE + +V + H Sbjct: 69 KLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE 128 Query: 128 KGVYHRDLKPENLL--LDTNGN--LKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLS- 182 G+ HR++KP N++ + +G K++DFG + ++ + + + GT Y+ P++ Sbjct: 129 NGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFV-SLYGTEEYLHPDMYER 187 Query: 183 ------GQGYDGSAADIWSCGVILFVILAGYLPFSETDLP----GLYRKINAAEFS 228 Q G+ D+WS GV + G LPF + P + KI + S Sbjct: 188 AVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS 243 >4MD7-E nrPDB Length = 391 Score = 176 bits (448), Expect = 1e-44, Method: Composition-based stats. Identities = 70/336 (20%), Positives = 128/336 (38%), Gaps = 53/336 (15%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 Y++ R +G G +++V A N + ILK +IKREI I++ +R Sbjct: 37 DDYQLVRKLGRGKYSEVFEAINITNNEK------VVVKILKPVKKKKIKREIKILENLRG 90 Query: 69 -PNIVRLYEVLASP--SKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHC 125 PNI+ L +++ P +V E V + L + + R Y +++ A+ +C Sbjct: 91 GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ---TLTDYDIRFYMYEILKALDYC 147 Query: 126 HCKGVYHRDLKPENLLLD-TNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQ 184 H G+ HRD+KP N+++D + L++ D+GL+ G E + + PE+L Sbjct: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEY-NVRVASRYFKGPELLVDY 206 Query: 185 GYDGSAADIWSCGVILFVILAGYLPF-SETDL-------------PGLYRKINAAEFSCP 230 + D+WS G +L ++ PF D LY I+ Sbjct: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 266 Query: 231 PWF------------------------SAEVKFLIHRILDPNPKTRIQIQGIKKDPWF-R 265 P F S E + ++L + ++R+ + + P+F Sbjct: 267 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYT 326 Query: 266 LNYVPIRAREEEEVNLDDIRAVFDGIEGSYVAENVE 301 + R + + + + G E Sbjct: 327 VVKDQARMGSSSMPGGSEPVSSANMMSGISSVPEPE 362 >2Y4I-B nrPDB Length = 319 Score = 176 bits (448), Expect = 1e-44, Method: Composition-based stats. Identities = 62/271 (22%), Positives = 115/271 (42%), Gaps = 27/271 (9%) Query: 8 VGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR 67 + E+G IG+G F +V R VAI+++ ++ + KRE+ + R Sbjct: 32 FEQLEIGELIGKGRFGQVYHGRWHG---EVAIRLIDIERDNED-QLKAFKREVMAYRQTR 87 Query: 68 HPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKG-RLEESESRKYFQQLVDAVAHCH 126 H N+V SP + I+ G L+ + L+ +++R+ Q++V + + H Sbjct: 88 HENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLH 147 Query: 127 CKGVYHRDLKPENLLLDTNGNLKVSDFGL---SALPQEG--VELLRTTCGTPNYVAPEVL 181 KG+ H+DLK +N+ D NG + ++DFGL S + Q G + LR G ++APE++ Sbjct: 148 AKGILHKDLKSKNVFYD-NGKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAPEII 206 Query: 182 SGQGYDGSA--------ADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWF 233 D +D+++ G I + + A PF + ++ P Sbjct: 207 RQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGTG---MKPNL 263 Query: 234 SA-----EVKFLIHRILDPNPKTRIQIQGIK 259 S E+ ++ + R + Sbjct: 264 SQIGMGKEISDILLFCWAFEQEERPTFTKLM 294 >3RAW-A nrPDB Length = 381 Score = 176 bits (447), Expect = 2e-44, Method: Composition-based stats. Identities = 67/328 (20%), Positives = 112/328 (34%), Gaps = 81/328 (24%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGD-NVAIKIMAKSTILKNRMVDQIKREISIMKIVR 67 +YE+ +GEGTF KV + G VA+KI+ + + + EI+++K ++ Sbjct: 51 ERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNV----GKYREAARLEINVLKKIK 106 Query: 68 HPN------IVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKG--RLEESESRKYFQQLV 119 + V + + + I E + G F+ + R QL Sbjct: 107 EKDKENKFLCVLMSDWFNFHGHMCIAFELL-GKNTFEFLKENNFQPYPLPHVRHMAYQLC 165 Query: 120 DAVAHCHCKGVYHRDLKPENLLL-------------------DTNGNLKVSDFGLSALPQ 160 A+ H + H DLKPEN+L N +++V+DFG + Sbjct: 166 HALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDH 225 Query: 161 EGVELLRTTCGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYR 220 E T T +Y PEV+ G+ D+WS G ILF G+ F + Sbjct: 226 EH---HTTIVATRHYRPPEVILELGW-AQPCDVWSIGCILFEYYRGFTLFQTHENREHLV 281 Query: 221 KINAAEFSCPPWF--------------------SAEVK---------------------- 238 + P S++ + Sbjct: 282 MMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQ 341 Query: 239 --FLIHRILDPNPKTRIQIQGIKKDPWF 264 L+ R+L+ +P RI + P+F Sbjct: 342 LFDLMRRMLEFDPAQRITLAEALLHPFF 369 >6HV0-A nrPDB Length = 416 Score = 175 bits (443), Expect = 5e-44, Method: Composition-based stats. Identities = 62/266 (23%), Positives = 107/266 (40%), Gaps = 26/266 (9%) Query: 16 TIGEGTFAK-VKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR-HPNIVR 73 +G G V +VA+K + RE+ +++ HPN++R Sbjct: 15 VLGHGAEGTIVYRG--MFDNRDVAVKRILPECFS------FADREVQLLRESDEHPNVIR 66 Query: 74 LYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEES-ESRKYFQQLVDAVAHCHCKGVYH 132 + YI +E L + + K E QQ +AH H + H Sbjct: 67 YFCTEKDRQFQYIAIELCAA-TLQEYVEQKDFAHLGLEPITLLQQTTSGLAHLHSLNIVH 125 Query: 133 RDLKPENLLL---DTNGNLK--VSDFGLSALP---QEGVELLRTTCGTPNYVAPEVLSG- 183 RDLKP N+L+ + +G +K +SDFGL + GT ++APE+LS Sbjct: 126 RDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSED 185 Query: 184 -QGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAAEFSC--PPWFSAE-VK 238 + DI+S G + + +++ G PF ++ + A C P + Sbjct: 186 CKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANILLGACSLDCLHPEKHEDVIAR 245 Query: 239 FLIHRILDPNPKTRIQIQGIKKDPWF 264 LI +++ +P+ R + + K P+F Sbjct: 246 ELIEKMIAMDPQKRPSAKHVLKHPFF 271 >1PY5-A nrPDB Length = 326 Score = 174 bits (442), Expect = 5e-44, Method: Composition-based stats. Identities = 64/293 (21%), Positives = 114/293 (38%), Gaps = 54/293 (18%) Query: 13 VGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMK--IVRHPN 70 + +IG+G F +V + G+ VA+KI + +R RE I + ++RH N Sbjct: 33 LQESIGKGRFGEVWRGKWR--GEEVAVKIFS------SREERSWFREAEIYQTVMLRHEN 84 Query: 71 IVRLYEVLASPS----KIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCH 126 I+ + ++++V ++ G LFD + ++ + K +AH H Sbjct: 85 ILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYL-NRYTVTVEGMIKLALSTASGLAHLH 143 Query: 127 --------CKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELL----RTTCGTPN 174 + HRDLK +N+L+ NG ++D GL+ + + GT Sbjct: 144 MEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKR 203 Query: 175 YVAPEVL-----SGQGYDGSAADIWSCGVILFVILAG----------YLPF-----SETD 214 Y+APEVL ADI++ G++ + I LP+ S+ Sbjct: 204 YMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPS 263 Query: 215 LPGLYRKINAAEFS--CP-PWFSAEV----KFLIHRILDPNPKTRIQIQGIKK 260 + + + + + P W S E ++ N R+ IKK Sbjct: 264 VEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKK 316 >6HMD-A nrPDB Length = 365 Score = 173 bits (438), Expect = 2e-43, Method: Composition-based stats. Identities = 65/298 (21%), Positives = 118/298 (39%), Gaps = 52/298 (17%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 Y++ R +G G +++V A N + ILK +IKRE+ I++ +R Sbjct: 53 DDYQLVRKLGRGKYSEVFEAINITNNER------VVVKILKPVKKKKIKREVKILENLRG 106 Query: 69 P-NIVRLYEVLASP--SKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHC 125 NI++L + + P +V E++ + L + + R Y +L+ A+ +C Sbjct: 107 GTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ---ILTDFDIRFYMYELLKALDYC 163 Query: 126 HCKGVYHRDLKPENLLLDTN-GNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQ 184 H KG+ HRD+KP N+++D L++ D+GL+ E + + PE+L Sbjct: 164 HSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEY-NVRVASRYFKGPELLVDY 222 Query: 185 GYDGSAADIWSCGVILFVILAGYLPF-SETDL-------------PGLYRKINAAEFSCP 230 + D+WS G +L ++ PF D LY + Sbjct: 223 QMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLD 282 Query: 231 PWF------------------------SAEVKFLIHRILDPNPKTRIQIQGIKKDPWF 264 P F S E L+ ++L + + R+ + + P+F Sbjct: 283 PHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 340 >6EII-A nrPDB Length = 352 Score = 172 bits (436), Expect = 3e-43, Method: Composition-based stats. Identities = 67/298 (22%), Positives = 120/298 (40%), Gaps = 52/298 (17%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 Y++ R +G G +++V A N + ILK +IKREI I++ +R Sbjct: 60 DDYQLVRKLGRGKYSEVFEAINITNNEK------VVVKILKPVKKKKIKREIKILENLRG 113 Query: 69 -PNIVRLYEVLASP--SKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHC 125 PNI+ L +++ P +V E V + L + + R Y +++ A+ +C Sbjct: 114 GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ---TLTDYDIRFYMYEILKALDYC 170 Query: 126 HCKGVYHRDLKPENLLLD-TNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQ 184 H G+ HRD+KP N+++D + L++ D+GL+ G E + + PE+L Sbjct: 171 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEY-NVRVASRYFKGPELLVDY 229 Query: 185 GYDGSAADIWSCGVILFVILAGYLPF-SETDL-------------PGLYRKINAAEFSCP 230 + D+WS G +L ++ PF D LY I+ Sbjct: 230 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 289 Query: 231 PWF------------------------SAEVKFLIHRILDPNPKTRIQIQGIKKDPWF 264 P F S E + ++L + ++R+ + + P+F Sbjct: 290 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 347 >5XD6-A nrPDB Length = 305 Score = 172 bits (436), Expect = 3e-43, Method: Composition-based stats. Identities = 55/219 (25%), Positives = 89/219 (40%), Gaps = 20/219 (9%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 Y IGEG++ +V + +G AIK + S + ++S++ +R Sbjct: 22 DNYGSKSLIGEGSYGRVFYGILK-SGKAAAIKKLDSSKQPD----QEFLAQVSMVSRLRQ 76 Query: 69 PNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGR---------LEESESRKYFQQLV 119 N+V L + E+ G L D + + L + K Sbjct: 77 ENVVALLGYCVDGPLRVLAYEYAPNGSLHDILHGRKGVKGAQPGPVLSWHQRVKIAVGAA 136 Query: 120 DAVAHCHCK---GVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTT--CGTPN 174 + + H K V HRD+K N+LL + K++DF LS + L +T GT Sbjct: 137 RGLEYLHEKANPHVIHRDIKSSNVLLFDDDVAKIADFDLSNQAPDMAARLHSTRVLGTFG 196 Query: 175 YVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSET 213 Y APE + G + +D++S GV+L +L G P T Sbjct: 197 YHAPE-YAMTGTLSTKSDVYSFGVVLLELLTGRKPVDHT 234 >4WUA-A nrPDB Length = 401 Score = 171 bits (435), Expect = 4e-43, Method: Composition-based stats. Identities = 76/369 (20%), Positives = 123/369 (33%), Gaps = 121/369 (32%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 G+Y V R +G G F+ V + + VA+K++ + +D EI ++K VR+ Sbjct: 41 GRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALD----EIRLLKSVRN 96 Query: 69 --PN------IVRLYEVLA----SPSKIYIVLEFVTGGELFDRIVHKG--RLEESESRKY 114 PN +V+L + + + I +V E V G L I+ L +K Sbjct: 97 SDPNDPNREMVVQLLDDFKISGVNGTHICMVFE-VLGHHLLKWIIKSNYQGLPLPCVKKI 155 Query: 115 FQQLVDAVAHCHCK-GVYHRDLKPENLLLDTNGN-------------------------- 147 QQ++ + + H K + H D+KPEN+LL N Sbjct: 156 IQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVS 215 Query: 148 -----------------------LKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQ 184 +K++D G + + T Y + EVL G Sbjct: 216 TAPATAGNFLVNPLEPKNAEKLKVKIADLGNACWVHKH---FTEDIQTRQYRSLEVLIGS 272 Query: 185 GYDGSAADIWSCGVILFVILAGYLPFS---------ETDLPGLY---------RKINAAE 226 GY+ ADIWS + F + G F + D L + I A + Sbjct: 273 GYNT-PADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGK 331 Query: 227 FS---------------CPPW-----------FSAE----VKFLIHRILDPNPKTRIQIQ 256 +S PW +S E + +L+ P+ R Sbjct: 332 YSKEFFTKKGDLKHITKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATAA 391 Query: 257 GIKKDPWFR 265 + PW Sbjct: 392 ECLRHPWLN 400 >2JD5-A nrPDB Length = 373 Score = 170 bits (432), Expect = 9e-43, Method: Composition-based stats. Identities = 71/341 (20%), Positives = 129/341 (37%), Gaps = 81/341 (23%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 +Y + R +G G F+ V A++ +VA+KI+ + D EI +++ V Sbjct: 20 RYILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVRGDKVYTEAAED----EIKLLQRVNDA 75 Query: 70 -----------NIVRLYEVLASPSK--IYIVLEF-VTGGELFDRIVH--KGRLEESESRK 113 +I++L + +++V+ F V G L I + ++ Sbjct: 76 DNTKEDSMGANHILKLLDHFNHKGPNGVHVVMVFEVLGENLLALIKKYEHRGIPLIYVKQ 135 Query: 114 YFQQLVDAVAHCHCK-GVYHRDLKPENLL---LDTNGN---LKVSDFGLSALPQEGVELL 166 +QL+ + + H + G+ H D+KPEN+L +D+ N +K++D G + E Sbjct: 136 ISKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNACWYDEHY--- 192 Query: 167 RTTCGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSET------------- 213 + T Y +PEVL G + G ADIWS ++F ++ G F Sbjct: 193 TNSIQTREYRSPEVLLGAPW-GCGADIWSTACLIFELITGDFLFEPDEGHSYTKDDDHIA 251 Query: 214 ------------------------DLPGLYRKINA-----------AEFSCPPWFSAEVK 238 + GL R I+ ++ + E+ Sbjct: 252 QIIELLGELPSYLLRNGKYTRTFFNSRGLLRNISKLKFWPLEDVLTEKYKFSKDEAKEIS 311 Query: 239 FLIHRILDPNPKTRIQIQGIKKDPWFR--LNYVPIRAREEE 277 + +L +P+ R G+ PW + L IR + E Sbjct: 312 DFLSPMLQLDPRKRADAGGLVNHPWLKDTLGMEEIRVPDRE 352 >2X7G-A nrPDB Length = 389 Score = 170 bits (430), Expect = 1e-42, Method: Composition-based stats. Identities = 66/367 (17%), Positives = 115/367 (31%), Gaps = 119/367 (32%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR- 67 G+Y V R +G G F+ V + VA+K++ + +D EI ++K VR Sbjct: 31 GRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALD----EIKLLKCVRE 86 Query: 68 ----HPN---IVRLYEVLASPS----KIYIVLEFVTGGELFDRIVHKG--RLEESESRKY 114 PN +V+L + + +V E V G L I+ L + Sbjct: 87 SDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFE-VLGHHLLKWIIKSNYQGLPVRCVKSI 145 Query: 115 FQQLVDAVAHCHCK-GVYHRDLKPENLLLDTNG--------------------------- 146 +Q++ + + H K + H D+KPEN+L+ + Sbjct: 146 IRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAVS 205 Query: 147 --------------------NLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGY 186 +K++D G + + T Y + EVL G GY Sbjct: 206 TAPAADLLVNPLDPRNADKIRVKIADLGNACWVHKH---FTEDIQTRQYRSIEVLIGAGY 262 Query: 187 DGSAADIWSCGVILFVILAGYL---PFSETDLP--------------------------- 216 + ADIWS + F + G P S D Sbjct: 263 -STPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYS 321 Query: 217 -GLYRK-----------------INAAEFSCPPWFSAEVKFLIHRILDPNPKTRIQIQGI 258 + + + ++ P +A+ + +L+ P+ R Sbjct: 322 REFFNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGEC 381 Query: 259 KKDPWFR 265 + PW Sbjct: 382 LRHPWLN 388 >3REP-A nrPDB Length = 271 Score = 169 bits (428), Expect = 2e-42, Method: Composition-based stats. Identities = 47/249 (18%), Positives = 104/249 (41%), Gaps = 24/249 (9%) Query: 23 AKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYEVLASPS 82 ++ R G+++ +K++ K R E ++I HPN++ + SP Sbjct: 24 GELWKGRW--QGNDIVVKVL-KVRDWSTRKSRDFNEECPRLRIFSHPNVLPVLGACQSPP 80 Query: 83 KIY--IVLEFVTGGELFDRIVHKGRL--EESESRKYFQQLVDAVAHCH--CKGVYHRDLK 136 + ++ ++ G L++ + ++S++ K+ + +A H + L Sbjct: 81 APHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFLHTLEPLIPRHALN 140 Query: 137 PENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCG---TPNYVAPEVLSGQGYDG--SAA 191 ++++D + ++S V+ + G P +VAPE L + D +A Sbjct: 141 SRSVMIDEDMTARIS--------MADVKFSFQSPGRMYAPAWVAPEALQKKPEDTNRRSA 192 Query: 192 DIWSCGVILFVILAGYLPFSETDLPGLYRKI--NAAEFSCPPWFSAEVKFLIHRILDPNP 249 D+WS V+L+ ++ +PF++ + K+ + PP S V L+ ++ +P Sbjct: 193 DMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTIPPGISPHVSKLMKICMNEDP 252 Query: 250 KTRIQIQGI 258 R + I Sbjct: 253 AKRPKFDMI 261 >5E8V-A nrPDB Length = 316 Score = 168 bits (426), Expect = 5e-42, Method: Composition-based stats. Identities = 57/295 (19%), Positives = 108/295 (36%), Gaps = 53/295 (17%) Query: 12 EVGRTIGEGTFAKVKFARNTDTG----DNVAIKIMAKSTILKNRMVDQIKREISIMKIVR 67 E+ +G+G FA+V A+ + VA+KI + I +I+ ++ Sbjct: 12 ELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDIN----LK 67 Query: 68 HPNIVRLYEVLASPSKI----YIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVA 123 H NI++ +++ +++ F G L + + + + RK L +A Sbjct: 68 HENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRH-VISWEDLRKLGSSLARGIA 126 Query: 124 HCHC---------KGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVEL----LRTTC 170 H H + HRDLK N+L+ + + DFGLS + + Sbjct: 127 HLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQV 186 Query: 171 GTPNYVAPEVL-----SGQGYDGSAADIWSCGVILFVILAG----------YLPF----- 210 GT Y+APEVL D++S ++L+ + + PF Sbjct: 187 GTARYMAPEVLASAMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVR 246 Query: 211 SETDLPGLYRKI--NAAEFSCPPWFSAE-----VKFLIHRILDPNPKTRIQIQGI 258 + + + +A P ++ V + D +P+ R+ Q + Sbjct: 247 EHPCVASMADNVLADAGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCV 301 >6BFN-A nrPDB Length = 342 Score = 167 bits (424), Expect = 7e-42, Method: Composition-based stats. Identities = 57/208 (27%), Positives = 80/208 (38%), Gaps = 19/208 (9%) Query: 16 TIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQ-IKREISIMKIVRHPNIVRL 74 IGEG F V A +T A+K + ++ L+ V Q E+ + RHPNIV Sbjct: 29 KIGEGGFGCVYRAVMRNT--VYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDF 86 Query: 75 YEVLASPSKIYIVLEFVTGGELFDRI----VHKGRLEESESRKYFQQLVDAVAHCH--CK 128 A +V F+ G L DR+ L + A+ H Sbjct: 87 AGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSP 146 Query: 129 GVYHRDLKPENLLLDTNGNLKVSDFGLSALP---------QEGVELLRTTCGTPNYVAPE 179 + H D+K N+LLD K+ DFGL+ V +T GT Y+ PE Sbjct: 147 SLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYL-PE 205 Query: 180 VLSGQGYDGSAADIWSCGVILFVILAGY 207 G D +S GV++ LAG Sbjct: 206 EYIKTGRLAVDTDTFSFGVVVLETLAGQ 233 >2QKW-B nrPDB Length = 321 Score = 167 bits (424), Expect = 7e-42, Method: Composition-based stats. Identities = 59/266 (22%), Positives = 109/266 (40%), Gaps = 28/266 (10%) Query: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYE 76 IG G F KV D G VA+K + T ++ +++ + EI + RHP++V L Sbjct: 47 IGHGVFGKVYKGVLRD-GAKVALK---RRTPESSQGIEEFETEIETLSFCRHPHLVSLIG 102 Query: 77 VLASPSKIYIVLEFVTGGELFDRI----VHKGRLEESESRKYFQQLVDAVAHCHCKGVYH 132 +++ ++ +++ G L + + + + + + + H + + H Sbjct: 103 FCDERNEMILIYKYMENGNLKRHLYGSDLPTMSMSWEQRLEICIGAARGLHYLHTRAIIH 162 Query: 133 RDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTC--GTPNYVAPEVLSGQGYDGSA 190 RD+K N+LLD N K++DFG+S E + +T GT Y+ PE +G Sbjct: 163 RDVKSINILLDENFVPKITDFGISKKGTELDQTHLSTVVKGTLGYIDPEYFI-KGRLTEK 221 Query: 191 ADIWSCGVILFVILAGY------LPFS---------ETDLPGLYRKINAAEF--SCPPWF 233 +D++S GV+LF +L LP E+ G +I P Sbjct: 222 SDVYSFGVVLFEVLCARSAIVQSLPREMVNLAEWAVESHNNGQLEQIVDPNLADKIRPES 281 Query: 234 SAEVKFLIHRILDPNPKTRIQIQGIK 259 + + L + + R + + Sbjct: 282 LRKFGDTAVKCLALSSEDRPSMGDVL 307 >4M66-A nrPDB Length = 325 Score = 165 bits (418), Expect = 4e-41, Method: Composition-based stats. Identities = 61/269 (22%), Positives = 105/269 (39%), Gaps = 33/269 (12%) Query: 14 GRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVR 73 +G+G F V A + +VA+KI+ +I E+ M +R+ N++ Sbjct: 25 LEFVGKGGFGVVFRAHHRTWNHDVAVKIVN---------SKKISWEVKAMVNLRNENVLL 75 Query: 74 LYEVLASPSKIY-----IVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHC- 127 L V + +V F+ G L + + + Q++V + + H Sbjct: 76 LLGVTEDLQWDFVSGQALVTRFMENGSLAGLLQPEAPRPWPLLCRLLQEVVLGMCYLHSL 135 Query: 128 -KGVYHRDLKPENLLLDTNGNLKVSDFGLSAL------PQEGVELLRTTCGTPNYVAPEV 180 + HRDLKP N+LLD + K++DFGLS R + GT Y+ PE+ Sbjct: 136 DPPLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGSGSGSGSRDSGGTLAYLDPEL 195 Query: 181 LSG-QGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCP----PWFSA 235 L A+D++S G++++ +LAG + + + P P S Sbjct: 196 LFKVNLKASKASDVYSFGILVWAVLAGREAELVDKTSLIRETVCDRQSRPPLTELPPGSP 255 Query: 236 E------VKFLIHRILDPNPKTRIQIQGI 258 E +K L+ + R Q Sbjct: 256 ETPGLEKLKELMIHCWGSQSENRPSFQDC 284 >3SOC-A nrPDB Length = 322 Score = 163 bits (413), Expect = 1e-40, Method: Composition-based stats. Identities = 54/287 (18%), Positives = 106/287 (36%), Gaps = 50/287 (17%) Query: 12 EVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNI 71 ++ G F V A+ + VA+KI ++++ Q + E+ + ++H NI Sbjct: 27 QLLEVKARGRFGCVWKAQLL--NEYVAVKIFP----IQDKQSWQNEYEVYSLPGMKHENI 80 Query: 72 VRLYEVLASPS----KIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHC 127 ++ + ++++ F G L D + + +E + + +A+ H Sbjct: 81 LQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFL-KANVVSWNELCHIAETMARGLAYLHE 139 Query: 128 ----------KGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTT--CGTPNY 175 + HRD+K +N+LL N ++DFGL+ + G T GT Y Sbjct: 140 DIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRY 199 Query: 176 VAPEVLSGQGYDGS----AADIWSCGVILFVILAGY-----------LPFSET-----DL 215 +APEVL G D+++ G++L+ + + LPF E L Sbjct: 200 MAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSL 259 Query: 216 PGLYRKI--NAAEFSCPPWFSAEV-----KFLIHRILDPNPKTRIQI 255 + + ++ I D + + R+ Sbjct: 260 EDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSA 306 >4IAN-A nrPDB Length = 358 Score = 162 bits (410), Expect = 3e-40, Method: Composition-based stats. Identities = 61/328 (18%), Positives = 116/328 (35%), Gaps = 81/328 (24%) Query: 10 KYEVGRTIGEGTFAKVKFARNT-DTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 +Y V G+G F+ V AR+ VA+KI+ + +++ +E+ +K + Sbjct: 31 RYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTG----LKELEFLKKLND 86 Query: 69 P------NIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGR---LEESESRKYFQQLV 119 + +RL+ + +V E ++ L + + G+ L R Y QQL Sbjct: 87 ADPDDKFHCLRLFRHFYHKQHLCLVFEPLSM-NLREVLKKYGKDVGLHIKAVRSYSQQLF 145 Query: 120 DAVAHCHCKGVYHRDLKPENLLLDTNGNL-KVSDFGLSALPQEGVELLRTTCGTPNYVAP 178 A+ + H D+KP+N+L++ + + K+ DFG ++ + + + Y AP Sbjct: 146 LALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVADND--ITPYLVSRFYRAP 203 Query: 179 EVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLY------------RKINAAE 226 E++ G+ YD D+WS G L+ + G + F + + I Sbjct: 204 EIIIGKSYD-YGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPNKMIRKGV 262 Query: 227 FSCPPWFSAEV-------------------------KFLIHRI----------------- 244 F F + K L+ + Sbjct: 263 FK-DQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLADLIGCQRLPEDQRKKVHQL 321 Query: 245 -------LDPNPKTRIQIQGIKKDPWFR 265 L +P RI I + + + Sbjct: 322 KDLLDQILMLDPAKRISINQALQHAFIQ 349 >5VDK-A nrPDB Length = 297 Score = 162 bits (410), Expect = 4e-40, Method: Composition-based stats. Identities = 54/292 (18%), Positives = 97/292 (33%), Gaps = 37/292 (12%) Query: 5 MRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMK 64 R ++ IG G F V G AIK + T + + E+ Sbjct: 11 SRYEKEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKR-SMKTFTELSNENSALHEVYAHA 69 Query: 65 IV-RHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHK----GRLEESESRKYFQQLV 119 ++ HP++VR Y A + I E+ GG L I EE + + Q+ Sbjct: 70 VLGHHPHVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQIS 129 Query: 120 DAVAHCHCKGVYHRDLKPENLLLDTNGN-----------------------LKVSDFGLS 156 + + H + H D+KP N+ + K+ D G + Sbjct: 130 LGLNYIHNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGDLGHA 189 Query: 157 ALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLP 216 + + G ++A E+L ADI++ G+ + + AG Sbjct: 190 TSINKP----KVEEGDSRFLANEILQEDYRHLPKADIFALGLTIA-VAAGAESLPTNGAA 244 Query: 217 GLYRKINAAEFS-CPPWFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLN 267 + I F P S L+ ++ P+ + R + ++ R + Sbjct: 245 --WHHIRKGNFPDVPQELSESFSSLLKNMIQPDAEQRPSAAALARNTVLRPS 294 >4LFI-A nrPDB Length = 374 Score = 161 bits (409), Expect = 5e-40, Method: Composition-based stats. Identities = 70/343 (20%), Positives = 127/343 (37%), Gaps = 84/343 (24%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAI------------------------KIMAKS 45 YE+ +G G +++V D+ + I K+ + Sbjct: 41 DYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTT 100 Query: 46 TILKNRMVDQIKREISIMKIVR----------HPNIVRLYEVLASP--SKIYIVLEFVTG 93 + ++E ++K +R H NI+ L++++ P +V E+V Sbjct: 101 LPFQKDQYYTNQKE-DVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDN 159 Query: 94 GELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLLD-TNGNLKVSD 152 D + +L + E R Y +L+ A+ +CH G+ HRD+KP N+++D N L++ D Sbjct: 160 ---VDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLID 216 Query: 153 FGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLP-FS 211 +GL+ +E + + PE+L + D+WS G +L ++ P F Sbjct: 217 WGLAEFYHVNMEY-NVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFH 275 Query: 212 ETDLPGLYRKINAA-------------EFSCPPWF------------------------S 234 T KI E + P F + Sbjct: 276 GTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGN 335 Query: 235 AEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEE 277 E+ LI +L + + R+ + PWF PIR + E+ Sbjct: 336 DEIIDLIDNLLRYDHQERLTAKEAMGHPWF----APIREQIEK 374 >4L00-A nrPDB Length = 304 Score = 158 bits (401), Expect = 4e-39, Method: Composition-based stats. Identities = 68/265 (25%), Positives = 109/265 (41%), Gaps = 23/265 (8%) Query: 14 GRTIGEGTFAKVKFAR------NTDTGDNVAIKIMAKSTILKNRMVDQIKREI-SIMKIV 66 G +G GT + + T + IK++ K +R + E S+M+ V Sbjct: 30 GEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQV 89 Query: 67 RHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGR--LEESESRKYFQQLVDAVAH 124 H +IV LY V + +V EFV GG L D +H+ L K +QL A+++ Sbjct: 90 SHKHIVYLYGVCVRDVENIMVEEFVEGGPL-DLFMHRKSDVLTTPWKFKVAKQLASALSY 148 Query: 125 CHCKGVYHRDLKPENLLLDTNGN-------LKVSDFGLSALPQEGVELLRTTCGTPNYVA 177 K + H ++ +NLLL G +K+SD G+ E + ++A Sbjct: 149 LEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIP----WIA 204 Query: 178 PEVLSGQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAAEFSCPPWFSAE 236 PE + AAD WS G L+ I G +P + L R + P E Sbjct: 205 PECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSC-KE 263 Query: 237 VKFLIHRILDPNPKTRIQIQGIKKD 261 + L+ R ++ +P R + I +D Sbjct: 264 LADLMTRCMNYDPNQRPFFRAIMRD 288 >3QD2-B nrPDB Length = 332 Score = 158 bits (401), Expect = 4e-39, Method: Composition-based stats. Identities = 69/333 (20%), Positives = 114/333 (34%), Gaps = 76/333 (22%) Query: 5 MRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMV----------- 53 R + +E + +G G F V A+N N AIK + R Sbjct: 2 SRYLTDFEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKL 61 Query: 54 -----------------DQIKRE---------------------------ISIMKIVRHP 69 ++ + E I M Sbjct: 62 EHPGIVRYFNAWLETPPEKWQEEMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFSTK 121 Query: 70 NIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESE---SRKYFQQLVDAVAHCH 126 N V + + +YI ++ L D + + LE+ E F Q+ +AV H Sbjct: 122 NTVGQLQPSSPKVYLYIQMQLCRKENLKDWMNRRCSLEDREHGVCLHIFIQIAEAVEFLH 181 Query: 127 CKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVE------------LLRTTCGTPN 174 KG+ HRDLKP N+ + +KV DFGL + E GT Sbjct: 182 SKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQVGTKL 241 Query: 175 YVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFS--CPPW 232 Y++PE + G Y DI+S G+ILF +L + ++ + + + +F Sbjct: 242 YMSPEQIHGNNY-SHKVDIFSLGLILFELLYSFS--TQMERVRIITDVRNLKFPLLFTQK 298 Query: 233 FSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFR 265 + E ++ +L P+P R + I ++ F Sbjct: 299 YPQE-HMMVQDMLSPSPTERPEATDIIENAIFE 330 >4M69-B nrPDB Length = 283 Score = 158 bits (401), Expect = 4e-39, Method: Composition-based stats. Identities = 50/250 (20%), Positives = 93/250 (37%), Gaps = 14/250 (5%) Query: 23 AKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQ-IKREISIMKIVRHPNIVRLYEVLAS- 80 + + + V IK+ +V EI MK PNI+R++ + Sbjct: 23 STIYRGEYHRS--PVTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICIDQ 80 Query: 81 ---PSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDLKP 137 P + IV+E+ G L + + + L S + + H HR++ Sbjct: 81 TVKPPEFSIVMEYCELGTLRELLDREKDLTMSVRSLLVLRAARGLYRLHHSETLHRNISS 140 Query: 138 ENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPN----YVAPEVLSGQ-GYDGSAAD 192 + L+ +K++ F LS ++T + YV+PE L A+ Sbjct: 141 SSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDIKAE 200 Query: 193 IWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCP--PWFSAEVKFLIHRILDPNPK 250 I+S G++L+ I G +PF D + + + P ++ +I+ P Sbjct: 201 IYSFGIVLWEIATGKIPFEGCDSKKIRELVAEDKKQEPVGQDCPELLREIINECRAHEPS 260 Query: 251 TRIQIQGIKK 260 R + GI + Sbjct: 261 QRPSVDGILE 270 >3LLT-A nrPDB Length = 360 Score = 158 bits (401), Expect = 4e-39, Method: Composition-based stats. Identities = 60/333 (18%), Positives = 111/333 (33%), Gaps = 87/333 (26%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 + V R +G+GTF +V ++ D A+K++ + K E I+K +++ + Sbjct: 37 FLVIRKMGDGTFGRVLLCQHIDNKKYYAVKVVRNI----KKYTRSAKIEADILKKIQNDD 92 Query: 71 I-----VRLYEVLASPSKIYIVLEFVTGGELFDRIVHKG--RLEESESRKYFQQLVDAVA 123 I V+ + + ++ E + G L++ I + + Y +++ A+ Sbjct: 93 INNNNIVKYHGKFMYYDHMCLIFEPL-GPSLYEIITRNNYNGFHIEDIKLYCIEILKALN 151 Query: 124 HCHCKGVYHRDLKPENLLLDTNGN-------------------------LKVSDFGLSAL 158 + + H DLKPEN+LLD +K+ DFG + Sbjct: 152 YLRKMSLTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTKSTGIKLIDFGCATF 211 Query: 159 PQEGVELLRTTCGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGL 218 + + T Y APEV+ G+D S +D+WS G +L + G L F + Sbjct: 212 KSD---YHGSIINTRQYRAPEVILNLGWDVS-SDMWSFGCVLAELYTGSLLFRTHEHMEH 267 Query: 219 YRKINAAEFSCPPWFSAEVK---------------------------------------- 238 + + P E Sbjct: 268 LAMMESIIQPIPKNMLYEATKTNGSKYVNKDELKLAWPENASSINSIKHVKKCLPLYKII 327 Query: 239 ------FLIHRILDPNPKTRIQIQGIKKDPWFR 265 ++ IL +P R + K + Sbjct: 328 KHELFCDFLYSILQIDPTLRPSPAELLKHKFLE 360 >4BTF-A nrPDB Length = 469 Score = 158 bits (400), Expect = 4e-39, Method: Composition-based stats. Identities = 50/250 (20%), Positives = 93/250 (37%), Gaps = 14/250 (5%) Query: 23 AKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQ-IKREISIMKIVRHPNIVRLYEVLAS- 80 + + + V IK+ +V EI MK PNI+R++ + Sbjct: 209 STIYRGEYHRS--PVTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICIDQ 266 Query: 81 ---PSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDLKP 137 P + IV+E+ G L + + + L S + + H HR++ Sbjct: 267 TVKPPEFSIVMEYCELGTLRELLDREKDLTMSVRSLLVLRAARGLYRLHHSETLHRNISS 326 Query: 138 ENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPN----YVAPEVLSGQ-GYDGSAAD 192 + L+ +K++ F LS ++T + YV+PE L A+ Sbjct: 327 SSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDIKAE 386 Query: 193 IWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCP--PWFSAEVKFLIHRILDPNPK 250 I+S G++L+ I G +PF D + + + P ++ +I+ P Sbjct: 387 IYSFGIVLWEIATGKIPFEGCDSKKIRELVAEDKKQEPVGQDCPELLREIINECRAHEPS 446 Query: 251 TRIQIQGIKK 260 R + GI + Sbjct: 447 QRPSVDGILE 456 >3VHK-A nrPDB Length = 368 Score = 157 bits (398), Expect = 7e-39, Method: Composition-based stats. Identities = 35/166 (21%), Positives = 69/166 (41%), Gaps = 6/166 (3%) Query: 101 VHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSA-LP 159 ++K L Y Q+ + + HRDL N+LL +K+ DFGL+ + Sbjct: 192 LYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIY 251 Query: 160 QEGVELLRTTCGTP-NYVAPEVLSGQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPG 217 ++ + + P ++APE + + Y +D+WS GV+L+ I + G P+ + Sbjct: 252 KDPDYVRKGDARLPLKWMAPETIFDRVY-TIQSDVWSFGVLLWEIFSLGASPYPGVKIDE 310 Query: 218 LY-RKINAA-EFSCPPWFSAEVKFLIHRILDPNPKTRIQIQGIKKD 261 + R++ P + + E+ + P R + + Sbjct: 311 EFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEH 356 Score = 78.8 bits (193), Expect = 5e-15, Method: Composition-based stats. Identities = 24/104 (23%), Positives = 43/104 (41%), Gaps = 9/104 (8%) Query: 9 GKYEVGRTIGEGTFAKVKFA-----RNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIM 63 + ++G+ +G G F +V A T T VA+K++ + + E+ I+ Sbjct: 29 DRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEH--RALMSELKIL 86 Query: 64 -KIVRHPNIVRLYEVLASP-SKIYIVLEFVTGGELFDRIVHKGR 105 I H N+V L P + +++EF G L + K Sbjct: 87 IHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRN 130 >3HNG-A nrPDB Length = 360 Score = 155 bits (392), Expect = 3e-38, Method: Composition-based stats. Identities = 36/164 (21%), Positives = 73/164 (44%), Gaps = 6/164 (3%) Query: 102 HKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQE 161 +K + + Y Q+ + + HRDL N+LL N +K+ DFGL+ + Sbjct: 192 YKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYK 251 Query: 162 GVELLR--TTCGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGL 218 + +R T ++APE + + Y + +D+WS GV+L+ I + G P+ + Sbjct: 252 NPDYVRKGDTRLPLKWMAPESIFDKIY-STKSDVWSYGVLLWEIFSLGGSPYPGVQMDED 310 Query: 219 Y-RKINAA-EFSCPPWFSAEVKFLIHRILDPNPKTRIQIQGIKK 260 + ++ P + + E+ ++ +PK R + + + Sbjct: 311 FCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVE 354 Score = 80.7 bits (198), Expect = 1e-15, Method: Composition-based stats. Identities = 22/105 (20%), Positives = 46/105 (43%), Gaps = 9/105 (8%) Query: 9 GKYEVGRTIGEGTFAKVKFA-----RNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIM 63 + ++G+++G G F KV A + + T VA+K++ + + E+ I+ Sbjct: 27 ERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASE--YKALMTELKIL 84 Query: 64 KIV-RHPNIVRLYEVLA-SPSKIYIVLEFVTGGELFDRIVHKGRL 106 + H N+V L + +++E+ G L + + K L Sbjct: 85 THIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKRDL 129 >5USZ-A nrPDB Length = 289 Score = 155 bits (391), Expect = 5e-38, Method: Composition-based stats. Identities = 63/275 (22%), Positives = 107/275 (38%), Gaps = 27/275 (9%) Query: 15 RTIGEGTFAKVKFARNTDTGD-------NVAIKIMAKSTILKNRMVDQIKREISIMKIVR 67 ++G+GTF K+ + GD V +K++ K+ + S+M + Sbjct: 14 ESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKA---HRNYSESFFEAASMMSKLS 70 Query: 68 HPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVH-KGRLEESESRKYFQQLVDAVAHCH 126 H ++V Y V + +V EFV G L + K + + +QL A+ Sbjct: 71 HKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAAAMHFLE 130 Query: 127 CKGVYHRDLKPENLLL--------DTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAP 178 + H ++ +N+LL +K+SD G+S ++L+ +V P Sbjct: 131 ENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLP-KDILQERI---PWVPP 186 Query: 179 EVLSGQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAAEFSCPPWFSAEV 237 E + A D WS G L+ I + G P S D + P +AE+ Sbjct: 187 ECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYED-RHQLPAPKAAEL 245 Query: 238 KFLIHRILDPNPKTRIQIQGIKKD--PWFRLNYVP 270 LI+ +D P R + I +D F + VP Sbjct: 246 ANLINNCMDYEPDHRPSFRAIIRDLNSLFTPDLVP 280 >3SV0-A nrPDB Length = 483 Score = 155 bits (391), Expect = 5e-38, Method: Composition-based stats. Identities = 59/244 (24%), Positives = 97/244 (39%), Gaps = 30/244 (12%) Query: 3 KKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISI 62 + R K+ +GR IG G+F ++ N T + VAIK+ T Q+ E I Sbjct: 1 MEPRVGNKFRLGRKIGSGSFGEIYLGTNIQTNEEVAIKLENVKT-----KHPQLLYESKI 55 Query: 63 MKIVRH----PNIVRLYEVLASPSKIYIVLEFV--TGGELFDRIVHKGRLEESESRKYFQ 116 +I++ PN VR + V +V++ + + +LF+ K L Sbjct: 56 YRILQGGTGIPN-VRWFGV--EGDYNVLVMDLLGPSLEDLFNFCSRK--LSLKTVLMLAD 110 Query: 117 QLVDAVAHCHCKGVYHRDLKPENLLLD---TNGNLKVSDFGLSALPQE-------GVELL 166 Q+++ V H K HRD+KP+N L+ + + DFGL+ ++ Sbjct: 111 QMINRVEFVHSKSFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDTSTHQHIPYREN 170 Query: 167 RTTCGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSE---TDLPGLYRKIN 223 + GT Y + G D+ S G +L L G LP+ Y KI+ Sbjct: 171 KNLTGTARYASVNTHLGIE-QSRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKYEKIS 229 Query: 224 AAEF 227 + Sbjct: 230 EKKV 233 >4F9B-A nrPDB Length = 361 Score = 155 bits (391), Expect = 5e-38, Method: Composition-based stats. Identities = 71/345 (20%), Positives = 118/345 (34%), Gaps = 100/345 (28%) Query: 11 YEVGRTIGEGTFAKVKFAR---NTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR 67 +++ IGEGTF+ V A + +A+K + ++ +I E+ + + Sbjct: 23 FKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHP-----IRIAAELQCLTVAG 77 Query: 68 H-PNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCH 126 N++ + + I + ++ D + L E R+Y L A+ H Sbjct: 78 GQDNVMGVKYCFRKNDHVVIAMPYLEHESFLDIL---NSLSFQEVREYMLNLFKALKRIH 134 Query: 127 CKGVYHRDLKPENLLLDTNGNLK---VSDFGLSALPQEGV-------------------- 163 G+ HRD+KP N L N LK + DFGL+ + Sbjct: 135 QFGIVHRDVKPSNFLY--NRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNK 192 Query: 164 --------ELLRTTCGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPF----- 210 + + GTP + APEVL+ +A D+WS GVI +L+G PF Sbjct: 193 CSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASD 252 Query: 211 ----------------------------------SETDLPGLYRKINAAEFSCPP----- 231 DL L ++ + S P Sbjct: 253 DLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSSTPKLTSDI 312 Query: 232 -----------WFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFR 265 E L+ ++LD NP +RI + P+F+ Sbjct: 313 QGHATNLEGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFFK 357 >3G2F-A nrPDB Length = 336 Score = 153 bits (388), Expect = 1e-37, Method: Composition-based stats. Identities = 59/315 (18%), Positives = 104/315 (33%), Gaps = 65/315 (20%) Query: 2 TKKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREIS 61 ++ + ++ IG G + V + VA+K+ + + E + Sbjct: 6 SEPSLDLDNLKLLELIGRGRYGAVYKG--SLDERPVAVKVFSFAN------RQNFINEKN 57 Query: 62 IMK--IVRHPNIVRLY----EVLASPSKIYI-VLEFVTGGELFDRIVHKGRLEESESRKY 114 I + ++ H NI R V A Y+ V+E+ G L + + S + Sbjct: 58 IYRVPLMEHDNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTS-DWVSSCRL 116 Query: 115 FQQLVDAVAHCHC---------KGVYHRDLKPENLLLDTNGNLKVSDFGLS--------A 157 + +A+ H + HRDL N+L+ +G +SDFGLS Sbjct: 117 AHSVTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLV 176 Query: 158 LPQEGVELLRTTCGTPNYVAPEVLSGQGYDG------SAADIWSCGVILFVILAGYL-PF 210 P E + GT Y+APEVL G D+++ G+I + I F Sbjct: 177 RPGEEDNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLF 236 Query: 211 SETDLPG-------------------LYRKINAAEFSCPPWFSAE------VKFLIHRIL 245 +P + P + +K I Sbjct: 237 PGESVPEYQMAFQTEVGNHPTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETIEDCW 296 Query: 246 DPNPKTRIQIQGIKK 260 D + + R+ Q ++ Sbjct: 297 DQDAEARLTAQCAEE 311 >2QLU-A nrPDB Length = 314 Score = 153 bits (386), Expect = 2e-37, Method: Composition-based stats. Identities = 58/281 (20%), Positives = 108/281 (38%), Gaps = 51/281 (18%) Query: 19 EGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYEVL 78 G F V A+ D VA+KI L+++ Q +REI ++H N+++ Sbjct: 25 RGRFGCVWKAQLM--NDFVAVKIFP----LQDKQSWQSEREIFSTPGMKHENLLQFIAAE 78 Query: 79 ASPS----KIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHC------- 127 S +++++ F G L D + + +E + + +++ H Sbjct: 79 KRGSNLEVELWLITAFHDKGSLTDYL-KGNIITWNELCHVAETMSRGLSYLHEDVPWCRG 137 Query: 128 ----KGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTT--CGTPNYVAPEVL 181 + HRD K +N+LL ++ ++DFGL+ + G T GT Y+APEVL Sbjct: 138 EGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTRRYMAPEVL 197 Query: 182 SGQGYDGS----AADIWSCGVILFVILAGY-----------LPFSET-----DLPGLYRK 221 G D+++ G++L+ +++ LPF E L L Sbjct: 198 EGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEELQEV 257 Query: 222 I--NAAEFSCPPWF--SAEVKFL---IHRILDPNPKTRIQI 255 + + + + L I D + + R+ Sbjct: 258 VVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSA 298 >5X1R-A nrPDB Length = 302 Score = 153 bits (386), Expect = 2e-37, Method: Composition-based stats. Identities = 53/273 (19%), Positives = 102/273 (37%), Gaps = 30/273 (10%) Query: 7 RVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRM-------------- 52 R ++E+ IGEG F V A + +AIK +++ K Sbjct: 19 RFNEFEIQEAIGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAKRNDDLSIGLRGERFGKT 78 Query: 53 ----VDQIKREISIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFD-RIVHKGRLE 107 ++ +E ++ HP ++ + Y+ +F +G L + + +++ Sbjct: 79 FQAGLNSFIQEARLLARFSHPGLLHVLRFWEENGTAYMGTQFYSGTTLKNLQAQQPEKID 138 Query: 108 ESESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLR 167 E+ R+ L A+ H +G HRD+ +N+ + + + DFG + + Sbjct: 139 EAWIRRLLPPLFSAINTIHQEGYLHRDISLDNIQIQESQLPVLLDFGSARKEIGNLSDET 198 Query: 168 TTCGTPNYVAPEVL--SGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAA 225 P + E + G G DI++ G +L ++ G P + R I + Sbjct: 199 EIVLKPGFAPIEQYTENSDGEQGPWTDIYALGAVLHTLIVGSPP-----PVSVVRSIEDS 253 Query: 226 EFSC----PPWFSAEVKFLIHRILDPNPKTRIQ 254 P +S E+ + R L P+ R Q Sbjct: 254 YQPLTERRPAGYSPELLRTVDRALALKPEDRPQ 286 >4MWI-A nrPDB Length = 294 Score = 151 bits (383), Expect = 4e-37, Method: Composition-based stats. Identities = 48/238 (20%), Positives = 93/238 (39%), Gaps = 14/238 (5%) Query: 37 VAIKIMAKSTILKNRMVDQ-IKREISIMKIVRHPNIVRLYEVLAS----PSKIYIVLEFV 91 VAIK+ K +V Q +EI MK PNI+R++ + P + IV+E+ Sbjct: 50 VAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYC 109 Query: 92 TGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGV--YHRDLKPENLLLDTNGNLK 149 G L + + + L + + H H ++ N L+ +K Sbjct: 110 ELGTLRELLDREKDLTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQVK 169 Query: 150 VSDFGL----SALPQEGVELLRTTCGTPNYVAPEVLSGQGY-DGSAADIWSCGVILFVIL 204 ++ F L +++ + Y++P+ L Y ++I+S G++L+ I Sbjct: 170 LAGFELRKTQTSMSLGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWEIA 229 Query: 205 AGYLPFSETDLPGLYRKINAAEFSCP--PWFSAEVKFLIHRILDPNPKTRIQIQGIKK 260 G +PF + + + + P +E++ +I +P R + I K Sbjct: 230 TGDIPFQGCNSEKIRKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILK 287 >4TN6-A nrPDB Length = 318 Score = 150 bits (378), Expect = 2e-36, Method: Composition-based stats. Identities = 53/247 (21%), Positives = 93/247 (37%), Gaps = 24/247 (9%) Query: 3 KKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISI 62 ++R +Y +GR IG G+F + + G+ VAIK+ T Q+ E I Sbjct: 1 MELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKT-----KHPQLHIESKI 55 Query: 63 MKIVRHPNIVRLYEVL-ASPSKIYIVLEFV--TGGELFDRIVHKGRLEESESRKYFQQLV 119 K+++ + A +V+E + + +LF+ K Q++ Sbjct: 56 YKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRK--FSLKTVLLLADQMI 113 Query: 120 DAVAHCHCKGVYHRDLKPENLLLD---TNGNLKVSDFGLSALPQE-------GVELLRTT 169 + + H K HRD+KP+N L+ + + DFGL+ ++ + Sbjct: 114 SRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNL 173 Query: 170 CGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLP---GLYRKINAAE 226 GT Y + G D+ S G +L G LP+ Y +I+ + Sbjct: 174 TGTARYASINTHLGIE-QSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKK 232 Query: 227 FSCPPWF 233 S P Sbjct: 233 MSTPIEV 239 >5FQD-C nrPDB Length = 341 Score = 150 bits (378), Expect = 2e-36, Method: Composition-based stats. Identities = 55/241 (22%), Positives = 95/241 (39%), Gaps = 30/241 (12%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 GKY++ R IG G+F + A N G+ VA+K+ ++ Q+ E + KI++ Sbjct: 19 GKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKA-----RHPQLLYESKLYKILQG 73 Query: 69 ----PNIVRLYEVLASPSKIYIVLEFV--TGGELFDRIVHKGRLEESESRKYFQQLVDAV 122 P+I R Y +V++ + + +LF+ R Q++ + Sbjct: 74 GVGIPHI-RWYG--QEKDYNVLVMDLLGPSLEDLFNFCSR--RFTMKTVLMLADQMISRI 128 Query: 123 AHCHCKGVYHRDLKPENLLLDTNGNL---KVSDFGLSALPQEG-------VELLRTTCGT 172 + H K HRD+KP+N L+ + + DFGL+ ++ + GT Sbjct: 129 EYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGT 188 Query: 173 PNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSET---DLPGLYRKINAAEFSC 229 Y + G D+ S G +L LP+ Y KI+ + S Sbjct: 189 ARYASINAHLGIE-QSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMST 247 Query: 230 P 230 P Sbjct: 248 P 248 >4RT7-A nrPDB Length = 415 Score = 147 bits (371), Expect = 1e-35, Method: Composition-based stats. Identities = 42/207 (20%), Positives = 82/207 (39%), Gaps = 14/207 (6%) Query: 58 REISIMKIVRHPNIVRLYE-VLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQ 116 RE+ I I L+ S +I E+ + + L + + Sbjct: 198 REVQIHP--DSDQISGLHGNSFHSEDEI----EY-ENQKRLEEEEDLNVLTFEDLLCFAY 250 Query: 117 QLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSA-LPQEGVELLRTTCGTP-N 174 Q+ + K HRDL N+L+ +K+ DFGL+ + + ++R P Sbjct: 251 QVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVK 310 Query: 175 YVAPEVLSGQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAAEFSC--PP 231 ++APE L +G +D+WS G++L+ I + G P+ + + K+ F P Sbjct: 311 WMAPESLF-EGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPF 369 Query: 232 WFSAEVKFLIHRILDPNPKTRIQIQGI 258 + + E+ ++ + + R + Sbjct: 370 YATEEIYIIMQSCWAFDSRKRPSFPNL 396 Score = 94.2 bits (233), Expect = 1e-19, Method: Composition-based stats. Identities = 27/98 (27%), Positives = 45/98 (45%), Gaps = 8/98 (8%) Query: 12 EVGRTIGEGTFAKVKFARN---TDTG--DNVAIKIMAKSTILKNRMVDQIKREISIMKIV 66 E G+ +G G F KV A + TG VA+K++ + R + + E+ +M + Sbjct: 68 EFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSER--EALMSELKMMTQL 125 Query: 67 -RHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHK 103 H NIV L IY++ E+ G+L + + K Sbjct: 126 GSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSK 163 >5X18-A nrPDB Length = 295 Score = 146 bits (370), Expect = 1e-35, Method: Composition-based stats. Identities = 58/247 (23%), Positives = 98/247 (39%), Gaps = 30/247 (12%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH-P 69 Y++G+ IGEG+F + N G VAIK + T Q++ E KI+ P Sbjct: 9 YKIGKKIGEGSFGVLFEGTNMINGVPVAIKFEPRKT-----EAPQLRDEYKTYKILNGTP 63 Query: 70 NIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGR-LEESESRKYFQQLVDAVAHCHCK 128 NI Y +V++ + G L D GR + Q++ + H Sbjct: 64 NIPYAYYFGQEGLHNILVIDLL-GPSLEDLFDWCGRKFSVKTVVQVAVQMITLIEDLHAH 122 Query: 129 GVYHRDLKPENLLLDTNG-----NLKVSDFGLSALPQE-------GVELLRTTCGTPNYV 176 + +RD+KP+N L+ G N+ + DFG++ ++ ++ GT Y+ Sbjct: 123 DLIYRDIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRDPKTKQHIPYREKKSLSGTARYM 182 Query: 177 APEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSE---TDLPGLYRKINAAEFSCPPWF 233 + G+ D+ + G + F L G+LP+ + Y KI + Sbjct: 183 SINTHLGRE-QSRRDDMEALGHVFFYFLRGHLPWQGLKAPNNKQKYEKIGEKKR------ 235 Query: 234 SAEVKFL 240 S V L Sbjct: 236 STNVYDL 242 >4BTK-A nrPDB Length = 337 Score = 145 bits (367), Expect = 3e-35, Method: Composition-based stats. Identities = 53/249 (21%), Positives = 100/249 (40%), Gaps = 29/249 (11%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 +++V + IG G F ++ A + T +NVA+K+ + + +K E++++K ++ Sbjct: 56 DRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVES-----AQQPKQVLKMEVAVLKKLQG 110 Query: 69 P-NIVRLYEVLASPSKIYIVLEFVTGGELFD--RIVHKGRLEESESRKYFQQLVDAVAHC 125 ++ R + Y+V++ G L D R +G S + + +Q+++++ Sbjct: 111 KDHVCRFIGCGRNEKFNYVVMQL-QGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAI 169 Query: 126 HCKGVYHRDLKPENL----LLDTNGNLKVSDFGLSALPQEGVELLR------TTCGTPNY 175 H G HRD+KP N L T + DFGL+ +R GT Y Sbjct: 170 HSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRY 229 Query: 176 VAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSA 235 + + G D+WS +L G LP+ + I Sbjct: 230 ASVNAHKNREM-GRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKEK---------Y 279 Query: 236 EVKFLIHRI 244 E + L+ + Sbjct: 280 EHRMLLKHM 288 >2CHL-A nrPDB Length = 351 Score = 145 bits (367), Expect = 3e-35, Method: Composition-based stats. Identities = 55/241 (22%), Positives = 93/241 (38%), Gaps = 24/241 (9%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIV-RH 68 + VG+ IG G F +++ +N T + VAIK+ + Q+ E K + Sbjct: 31 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKS-----RAPQLHLEYRFYKQLGSG 85 Query: 69 PNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGR-LEESESRKYFQQLVDAVAHCHC 127 I ++Y +VLE + G L D R QL+ + + H Sbjct: 86 DGIPQVYYFGPCGKYNAMVLELL-GPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHS 144 Query: 128 KGVYHRDLKPENLLLDTNGN-----LKVSDFGLSALPQE-------GVELLRTTCGTPNY 175 K + +RD+KPEN L+ GN + + DF L+ + ++ GT Y Sbjct: 145 KNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARY 204 Query: 176 VAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSE---TDLPGLYRKINAAEFSCPPW 232 ++ G+ D+ + G + L G LP+ L Y+KI + + P Sbjct: 205 MSINTHLGKE-QSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIE 263 Query: 233 F 233 Sbjct: 264 V 264 >2CMW-A nrPDB Length = 310 Score = 145 bits (366), Expect = 4e-35, Method: Composition-based stats. Identities = 55/237 (23%), Positives = 93/237 (39%), Gaps = 25/237 (10%) Query: 12 EVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH--P 69 VG+ IG G F +++ +N T + VAIK+ + Q+ E K + Sbjct: 3 RVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKS-----RAPQLHLEYRFYKQLGSAGE 57 Query: 70 NIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGR-LEESESRKYFQQLVDAVAHCHCK 128 + ++Y +VLE + G L D R QL+ + + H K Sbjct: 58 GLPQVYYFGPCGKYNAMVLELL-GPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYVHSK 116 Query: 129 GVYHRDLKPENLLLDTNGN-----LKVSDFGLSALPQE-------GVELLRTTCGTPNYV 176 + +RD+KPEN L+ GN + + DFGL+ + ++ GT Y+ Sbjct: 117 NLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYM 176 Query: 177 APEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSE---TDLPGLYRKINAAEFSCP 230 + G+ D+ + G + L G LP+ L Y+KI + + P Sbjct: 177 SINTHLGKE-QSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRNTP 232 >4NFN-A nrPDB Length = 309 Score = 145 bits (365), Expect = 5e-35, Method: Composition-based stats. Identities = 53/249 (21%), Positives = 100/249 (40%), Gaps = 29/249 (11%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 +++V + IG G F ++ A + T +NVA+K+ + + +K E++++K ++ Sbjct: 21 DRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVES-----AQQPKQVLKMEVAVLKKLQG 75 Query: 69 P-NIVRLYEVLASPSKIYIVLEFVTGGELFD--RIVHKGRLEESESRKYFQQLVDAVAHC 125 ++ R + Y+V++ G L D R +G S + + +Q+++++ Sbjct: 76 KDHVCRFIGCGRNEKFNYVVMQL-QGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAI 134 Query: 126 HCKGVYHRDLKPENL----LLDTNGNLKVSDFGLSALPQEGVELLR------TTCGTPNY 175 H G HRD+KP N L T + DFGL+ +R GT Y Sbjct: 135 HSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRY 194 Query: 176 VAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSA 235 + + G D+WS +L G LP+ + I Sbjct: 195 ASVNAHKNREM-GRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKEK---------Y 244 Query: 236 EVKFLIHRI 244 E + L+ + Sbjct: 245 EHRMLLKHM 253 >2C47-A nrPDB Length = 313 Score = 143 bits (362), Expect = 1e-34, Method: Composition-based stats. Identities = 54/241 (22%), Positives = 93/241 (38%), Gaps = 24/241 (9%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR-H 68 + VG+ IG G F +++ +N T + VAIK+ + Q+ E K + Sbjct: 5 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKS-----RAPQLHLEYRFYKQLSAT 59 Query: 69 PNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGR-LEESESRKYFQQLVDAVAHCHC 127 + ++Y +VLE + G L D R QL+ + + H Sbjct: 60 EGVPQVYYFGPCGKYNAMVLELL-GPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYVHT 118 Query: 128 KGVYHRDLKPENLLLDTNGN-----LKVSDFGLSALPQE-------GVELLRTTCGTPNY 175 K + +RD+KPEN L+ G + + DFGL+ + ++ GT Y Sbjct: 119 KSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARY 178 Query: 176 VAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSE---TDLPGLYRKINAAEFSCPPW 232 ++ G+ D+ + G + L G LP+ L Y+KI + + P Sbjct: 179 MSINTHLGKE-QSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIE 237 Query: 233 F 233 Sbjct: 238 V 238 >5J0A-A nrPDB Length = 300 Score = 142 bits (358), Expect = 3e-34, Method: Composition-based stats. Identities = 55/286 (19%), Positives = 104/286 (36%), Gaps = 45/286 (15%) Query: 15 RTIGEGTFAK---VKFARNTDTGDNV---AIKIMAK--STILKNRMVDQIKREISIMKIV 66 + +G F V + + G + A+K + + ++ ++ E I+K + Sbjct: 15 QKLG---FGTGVNVYLMKRSPRGLSHSPWAVKKINPICNDHYRSVYQKRLMDEAKILKSL 71 Query: 67 RHPNIVRLYEVLA-SPSKIYIVLEFVTGGELFDRIVHK-----GRLEESESRKYFQQLVD 120 HPNIV + + + +E+ L D I + + K + Sbjct: 72 HHPNIVGYRAFTEANDGSLCLAMEYGGEKSLNDLIEERYKASQDPFPAAIILKVALNMAR 131 Query: 121 AVAHCHC-KGVYHRDLKPENLLLDTNG-NLKVSDFGLSALPQEGVELLRT---TCGTPNY 175 + + H K + H D+K N+++ + +K+ D G+S E +E+ GT + Sbjct: 132 GLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMEVTDPEACYIGTEPW 191 Query: 176 VAPEVLSGQGYDGSAADIWSCGVILFVILAGYLP--------------FSETDLPGLYRK 221 E + G ADI++ G+ L+ ++ +P F E+D Sbjct: 192 KPKEAVEENGVITDKADIFAFGLTLWEMMTLSIPHINLSNDDDDEDKTFDESDFDD--EA 249 Query: 222 INAAEFSCPPWFSAE-------VKFLIHRILDPNPKTRIQIQGIKK 260 AA + PP E V L + +PK R I + Sbjct: 250 YYAALGTRPPINMEELDESYQKVIELFSVCTNEDPKDRPSAAHIVE 295 >5M07-A nrPDB Length = 276 Score = 141 bits (357), Expect = 4e-34, Method: Composition-based stats. Identities = 52/256 (20%), Positives = 105/256 (41%), Gaps = 37/256 (14%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 Y V R +G +V ++ A+K+++ + + + +RE + + HP+ Sbjct: 32 YTVVRMLGASAMGEVYLVQHPGFPGWQALKVLSPAMAADDEFRRRFQRETEVAARLFHPH 91 Query: 71 IVRLYEVLASPSKIYIVLEFVTGGELFDRIVHK--GRLEESESRKYFQQLVDAVAHCHCK 128 I+ +++ +++I +++V G + + + L E + A+ + H + Sbjct: 92 ILEVHDRGEFDGQLWIAMDYVDGIDATQHMADRFPAVLPVGEVLAIVTAVAGALDYAHQR 151 Query: 129 GVYHRDLKPENLLLDT----NGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQ 184 G+ HRD+ P N++L + + + ++DFG+++ P+Y APE+ +G Sbjct: 152 GLLHRDVNPANVVLTSQSAGDQRILLADFGIASQ--------------PSYPAPELSAGA 197 Query: 185 GYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFL---- 240 DG AD ++ + + AG P + L PP SA L Sbjct: 198 DVDG-RADQYALALTAIHLFAGAPPVDRSHTGPLQ----------PPKLSAFRPDLARLD 246 Query: 241 --IHRILDPNPKTRIQ 254 + R L P R Sbjct: 247 GVLSRALATAPADRFG 262 >2PZI-A nrPDB Length = 681 Score = 141 bits (355), Expect = 8e-34, Method: Composition-based stats. Identities = 64/259 (24%), Positives = 111/259 (42%), Gaps = 29/259 (11%) Query: 8 VGKYEVGRTIGEGTFAKVKFARNTD-TGDNVAIKIMAKSTILKNRMVDQIKREISIMKIV 66 G+YEV I G + A + + G V +K + S + + + +R + V Sbjct: 79 AGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAER--QFLAEV 136 Query: 67 RHPNIVRLYEVLASPSKI-----YIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDA 121 HP+IV+++ + + YIV+E+V G L +L +E+ Y +++ A Sbjct: 137 VHPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSLKR--SKGQKLPVAEAIAYLLEILPA 194 Query: 122 VAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFG-LSALPQEGVELLRTTCGTPNYVAPEV 180 +++ H G+ + DLKPEN++L LK+ D G +S + G GTP + APE+ Sbjct: 195 LSYLHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINSFGY-----LYGTPGFQAPEI 248 Query: 181 LSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKF- 239 + A DI++ G L + DLP + P + Sbjct: 249 VRTGP--TVATDIYTVGRTLAAL--------TLDLPTRNGRYVDGLPEDDPVLKTYDSYG 298 Query: 240 -LIHRILDPNPKTRIQIQG 257 L+ R +DP+P+ R Sbjct: 299 RLLRRAIDPDPRQRFTTAE 317 >4Y12-A nrPDB Length = 375 Score = 140 bits (354), Expect = 1e-33, Method: Composition-based stats. Identities = 64/259 (24%), Positives = 111/259 (42%), Gaps = 29/259 (11%) Query: 8 VGKYEVGRTIGEGTFAKVKFARNTD-TGDNVAIKIMAKSTILKNRMVDQIKREISIMKIV 66 G+YEV I G + A + + G V +K + S + + + +R + V Sbjct: 118 AGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAER--QFLAEV 175 Query: 67 RHPNIVRLYEVLASPSKI-----YIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDA 121 HP+IV+++ + + YIV+E+V G L +L +E+ Y +++ A Sbjct: 176 VHPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSLKR--SKGQKLPVAEAIAYLLEILPA 233 Query: 122 VAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFG-LSALPQEGVELLRTTCGTPNYVAPEV 180 +++ H G+ + DLKPEN++L LK+ D G +S + G GTP + APE+ Sbjct: 234 LSYLHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINSFGY-----LYGTPGFQAPEI 287 Query: 181 LSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKF- 239 + A DI++ G L + DLP + P + Sbjct: 288 VRTGP--TVATDIYTVGRTLAAL--------TLDLPTRNGRYVDGLPEDDPVLKTYDSYG 337 Query: 240 -LIHRILDPNPKTRIQIQG 257 L+ R +DP+P+ R Sbjct: 338 RLLRRAIDPDPRQRFTTAE 356 >4NT4-A nrPDB Length = 312 Score = 138 bits (349), Expect = 3e-33, Method: Composition-based stats. Identities = 53/250 (21%), Positives = 96/250 (38%), Gaps = 36/250 (14%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIV-RH 68 + VG+ IG G F +++ +N ++VAIK+ + Q+ E K++ H Sbjct: 13 NFRVGKKIGCGNFGELRLGKNLYNNEHVAIKMEPMKS-----KAPQLHLEYRFYKLLGSH 67 Query: 69 --------PNIVRLYEVLASPSKIYIVLEFV--TGGELFDRIVHKGRLEESESRKYFQQL 118 P I L +VLE + + +LF+ K +QL Sbjct: 68 ADNAPDGIPRIYHL-GTC-GGRYNAMVLELLGLSLEDLFNICARK--FSLKTVLMIAKQL 123 Query: 119 VDAVAHCHCKGVYHRDLKPENLLLDTNGN-----LKVSDFGLSALPQE-------GVELL 166 + + + H + + +RD+KPEN L+ + + DFGL+ + Sbjct: 124 LHRIEYVHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHIPYREH 183 Query: 167 RTTCGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSE---TDLPGLYRKIN 223 ++ GT Y++ G+ D+ + G + L G LP+ L Y+KI Sbjct: 184 KSLTGTARYMSINTHMGRE-QSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIG 242 Query: 224 AAEFSCPPWF 233 + + P Sbjct: 243 DTKRATPIEV 252 >4XHH-A nrPDB Length = 403 Score = 132 bits (333), Expect = 3e-31, Method: Composition-based stats. Identities = 50/235 (21%), Positives = 88/235 (37%), Gaps = 22/235 (9%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 K+ +GR IG G+F + N +G+ VAI++ + + Q+ E + K + Sbjct: 8 KFRIGRKIGSGSFGDIYHGTNLISGEEVAIRLESIRS-----RHPQLDYESRVYKYLSGG 62 Query: 70 NIVRLYEVLASPSKIY-IVLEFVTGGELFDRIVHKGR-LEESESRKYFQQLVDAVAHCHC 127 + + +V++ + G L D + R Q++ V + H Sbjct: 63 VGIPFIRWFGREGEYNAMVIDLL-GPSLEDLFNYCHRKFSFKTVIMLALQMICRVQYIHG 121 Query: 128 KGVYHRDLKPENLLLD---TNGNLKVSDFGLSALPQE-------GVELLRTTCGTPNYVA 177 + HRD+KP+N L+ + V DFGLS ++ ++ GT Y + Sbjct: 122 RSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTARYAS 181 Query: 178 PEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSE---TDLPGLYRKINAAEFSC 229 G D+ S G +L G LP+ T Y +I + Sbjct: 182 VNTHLGIE-QSRRDDLESLGYMLIYFCKGSLPWQGLKATTKKQKYDRILEKKLCI 235 >1CSN-A nrPDB Length = 298 Score = 131 bits (331), Expect = 4e-31, Method: Composition-based stats. Identities = 60/268 (22%), Positives = 101/268 (37%), Gaps = 36/268 (13%) Query: 1 MTKKMRRVG-KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKRE 59 M+ + VG Y+VGR IGEG+F + N VAIK + + Q++ E Sbjct: 1 MSGQNNVVGVHYKVGRRIGEGSFGVIFEGTNLLNNQQVAIKFEPRRS-----DAPQLRDE 55 Query: 60 ISIMKIVRH----PNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGR-LEESESRKY 114 K++ PN+ Y +V++ + G L D + GR Sbjct: 56 YRTYKLLAGCTGIPNV---YYFGQEGLHNVLVIDLL-GPSLEDLLDLCGRKFSVKTVAMA 111 Query: 115 FQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGN-----LKVSDFGLSALPQE-------G 162 +Q++ V H K + +RD+KP+N L+ + + V DFG+ ++ Sbjct: 112 AKQMLARVQSIHEKSLVYRDIKPDNFLIGRPNSKNANMIYVVDFGMVKFYRDPVTKQHIP 171 Query: 163 VELLRTTCGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSET---DLPGLY 219 + GT Y++ G+ D+ + G + L G LP+ Y Sbjct: 172 YREKKNLSGTARYMSINTHLGRE-QSRRDDLEALGHVFMYFLRGSLPWQGLKAATNKQKY 230 Query: 220 RKINAAEFSCP-----PWFSAEVKFLIH 242 +I + S P F E +H Sbjct: 231 ERIGEKKQSTPLRELCAGFPEEFYKYMH 258 >5C01-A nrPDB Length = 342 Score = 130 bits (327), Expect = 1e-30, Method: Composition-based stats. Identities = 52/247 (21%), Positives = 92/247 (37%), Gaps = 24/247 (9%) Query: 28 ARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYEVLASPSKIYIV 87 R+ V +K++ S + S+M V H ++ ++ V + +V Sbjct: 101 GRDRGQELRVVLKVLDPSHH---DIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMV 157 Query: 88 LEFVTGGELFDRIVH-KGRLEESESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLL---- 142 E+V G L + +G + + QQL A+++ K + H ++ N+LL Sbjct: 158 TEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLG 217 Query: 143 ---DTNGNLKVSDFGL---SALPQEGVELLRTTCGTPNYVAPEVLSGQGYD-GSAADIWS 195 T+ +K+SD G+ + +E VE + ++APE L G +A D W Sbjct: 218 LAEGTSPFIKLSDPGVGLGALSREERVERIP-------WLAPECLPGGANSLSTAMDKWG 270 Query: 196 CGVILFVILA-GYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILDPNPKTRIQ 254 G L I G P + P ++ L + L P R Sbjct: 271 FGATLLEICFDGEAPLQSRSPSE-KEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPS 329 Query: 255 IQGIKKD 261 + I +D Sbjct: 330 FRTILRD 336 >4WOV-A nrPDB Length = 317 Score = 129 bits (326), Expect = 2e-30, Method: Composition-based stats. Identities = 52/247 (21%), Positives = 92/247 (37%), Gaps = 24/247 (9%) Query: 28 ARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYEVLASPSKIYIV 87 R+ V +K++ S + S+M V H ++ ++ V + +V Sbjct: 78 GRDRGQELRVVLKVLDPSHH---DIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMV 134 Query: 88 LEFVTGGELFDRIVH-KGRLEESESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLL---- 142 E+V G L + +G + + QQL A+++ K + H ++ N+LL Sbjct: 135 TEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLG 194 Query: 143 ---DTNGNLKVSDFGL---SALPQEGVELLRTTCGTPNYVAPEVLSGQGYD-GSAADIWS 195 T+ +K+SD G+ + +E VE + ++APE L G +A D W Sbjct: 195 LAEGTSPFIKLSDPGVGLGALSREERVERIP-------WLAPECLPGGANSLSTAMDKWG 247 Query: 196 CGVILFVILA-GYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILDPNPKTRIQ 254 G L I G P + P ++ L + L P R Sbjct: 248 FGATLLEICFDGEAPLQSRSPSE-KEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPS 306 Query: 255 IQGIKKD 261 + I +D Sbjct: 307 FRTILRD 313 >4XHL-A nrPDB Length = 394 Score = 129 bits (325), Expect = 2e-30, Method: Composition-based stats. Identities = 47/234 (20%), Positives = 88/234 (37%), Gaps = 24/234 (10%) Query: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 K+ +GR IG G+F + N +G+ VAI++ + + Q+ E + + + Sbjct: 8 KFRIGRKIGSGSFGDIYHGTNLISGEEVAIRLESIRS-----RHPQLDYESRVYRYLSGG 62 Query: 70 NIVRLYEVLASPSKIY-IVLEFV--TGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCH 126 + + +V++ + + +LF+ R Q+ + + H Sbjct: 63 VGIPFIRWFGREGEYNAMVIDLLGPSLEDLFNYCHR--RFSFKTVIMLALQMFCRIQYIH 120 Query: 127 CKGVYHRDLKPENLLLD---TNGNLKVSDFGLSALPQE-------GVELLRTTCGTPNYV 176 + HRD+KP+N L+ + V DFGLS ++ ++ GT Y Sbjct: 121 GRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTARYA 180 Query: 177 APEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSE---TDLPGLYRKINAAEF 227 + G D+ S G +L G LP+ T Y +I + Sbjct: 181 SVNTHLGIE-QSRRDDLESLGYVLIYFCKGSLPWQGLKATTKKQKYDRIMEKKL 233 >4JRN-A nrPDB Length = 372 Score = 129 bits (324), Expect = 3e-30, Method: Composition-based stats. Identities = 58/283 (20%), Positives = 100/283 (35%), Gaps = 46/283 (16%) Query: 14 GRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR------ 67 G +G G FA V A + +T + +A+K+ + + ++RE S + Sbjct: 73 GAPLGSGGFATVYEATDVETNEELAVKVFMSEKEPTDETMLDLQRESSCYRNFSLAKTAK 132 Query: 68 ----------HPNIVRL----------YEVLASPSKIYIVLEFVTGGELFDRI------- 100 ++V L + Y +L ++ I Sbjct: 133 DAQESCRFMVPSDVVMLEGQPASTEVVIGLTTRWVPNYFLLMMRAEADMSKVISWVFGDA 192 Query: 101 -VHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALP 159 V+K Q + VA+ +G+ H D+KP N LL +G L + DFG + Sbjct: 193 SVNKSEFGLVVRMYLSSQAIKLVANVQAQGIVHTDIKPANFLLLKDGRLFLGDFGTYRIN 252 Query: 160 QEGVELLRTTCGTPNYVAPEVLSGQG--YDGSAADIWSCGVILFVILAGYLPFSETDLPG 217 + GTP Y PE D W G+ L+ I P T G Sbjct: 253 NS----VGRAIGTPGYEPPERPFQATGITYTFPTDAWQLGITLYCIWCKERP---TPADG 305 Query: 218 LYRKINAAEFSCPPWFSAEVKFLIHRILDPNPKTRIQIQGIKK 260 ++ ++ A+ P V+ LI +L+ +P+ R+ + Sbjct: 306 IWDYLHFADCPSTPEL---VQDLIRSLLNRDPQKRMLPLQALE 345 >2ZFD-B nrPDB Length = 123 Score = 121 bits (305), Expect = 4e-28, Method: Composition-based stats. Identities = 31/101 (30%), Positives = 53/101 (52%), Gaps = 6/101 (5%) Query: 306 GPLMMNAFEMITLSQGLNLSALFDRRQDFVKRQTRFVSRREPSEIIANIEAVANSMGFK- 364 G MNAF++I+ S G NLS LF + + R RFVS ++ +E + ++ Sbjct: 2 GARRMNAFDIISGSPGFNLSGLFGDARKY-DRVERFVSAWTAERVVERLEEIVSAENLTV 60 Query: 365 SHTRNFKTRLEGLSSIKAGQLAVVIEIYEVAPSLFMVDVRK 405 + + ++EG + G A+V+EI ++ L M++VRK Sbjct: 61 AKKETWGMKIEG----QKGNFAMVVEINQLTDELVMIEVRK 97 >6J6I-B nrPDB Length = 351 Score = 121 bits (304), Expect = 7e-28, Method: Composition-based stats. Identities = 52/205 (25%), Positives = 88/205 (42%), Gaps = 16/205 (7%) Query: 35 DNVAIKIMAKSTIL-KNRMVDQIKREISI-MKIVRHPNIVRLYEVLASPSKIYIVLEFVT 92 + IK ++ I K V ++ +I + ++ H N ++L +V EF Sbjct: 82 RSYMIKRFSEDEITGKRHRVKEVYNDIVLSARMSNHSNFLQLLGCCLEFPFPVLVFEFAE 141 Query: 93 GGELFDR---IVH--KGRLEESESRKYFQQLVDAVAHCHC---KGVYHRDLKPENLLLDT 144 G + R IV+ + L S K +++ +AV + H K + HRD+KP ++ LD Sbjct: 142 HGAMNQRGGVIVNGEESLLPWSVRLKIGKEIANAVTYLHTAFPKIIIHRDVKPMHVFLDK 201 Query: 145 NGNLKVSDFGLSALPQEGVELLRT--TCGTPNYVAPEVLSGQGYDGSAADIWSCGVILFV 202 N K+SD S EG + GT Y+ P + + D++S G+ L V Sbjct: 202 NWTAKLSDLSFSISLPEGKSRIEAEWVLGTFGYIDP-LYHKTCFVTEYTDVYSFGICLLV 260 Query: 203 ILAGYLP---FSETDLPGLYRKINA 224 I+ G S+ DL G+ + Sbjct: 261 IITGKPAIMTISDGDLQGILSLVRE 285 >5OAT-A nrPDB Length = 411 Score = 120 bits (301), Expect = 1e-27, Method: Composition-based stats. Identities = 65/309 (21%), Positives = 111/309 (35%), Gaps = 63/309 (20%) Query: 8 VGKYEVGRTIGEGTFAKVK--FARNTDTGDN---VAIKIMAKSTILKNRM--VDQIKRE- 59 + +G+ I +GT V ++ +T DN A+K+M I +N M + + RE Sbjct: 10 LNDLSLGKPIAKGTNGVVYSAKVKDDETDDNKYPFALKMMFNYDIQENSMEILKAMYRET 69 Query: 60 ----------------ISIMKIVRH----PNIVRLYEVLAS-----------------PS 82 I + +H PNIV ++ V Sbjct: 70 VPARMYYSNHDLNNWEIELANRRKHLPPHPNIVAIFSVFTDLYPAALPPRLHPEGEGRNM 129 Query: 83 KIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLL 142 ++++++ L + S QL++ VAH G+ HRDLK +NLLL Sbjct: 130 SLFLLMKRYDC-NLQSFLSTAP--STRTSLLLLAQLLEGVAHMTAHGIAHRDLKSDNLLL 186 Query: 143 D----TNGNLKVSDFGLSALPQEG------VELLRTTCGTPNYVAPEVLSGQG-----YD 187 D + L +SDFG + G +APE++ + + Sbjct: 187 DTSEPESPILVISDFGCCLADKTNGLSLPYTSYEMDKGGNTALMAPEIICQKPGTFSVLN 246 Query: 188 GSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILDP 247 S AD+W+ G I + I + PF + P ++ L+ +L Sbjct: 247 YSKADLWAVGAIAYEIFNCHNPFYGPSRLKNFNYKEGDLPKLPDEVPTVIQALVANLLKR 306 Query: 248 NPKTRIQIQ 256 NP R+ + Sbjct: 307 NPNKRLDPE 315 >4I94-A nrPDB Length = 300 Score = 118 bits (296), Expect = 5e-27, Method: Composition-based stats. Identities = 49/244 (20%), Positives = 90/244 (36%), Gaps = 28/244 (11%) Query: 24 KVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYEVLASPSK 83 V + + +A+K + + +R Q E + +R+ + L + Sbjct: 44 VVYKGK-LENQRRIAVKRFNRKSWPDSR---QFLEEAKAVGQLRNHRMANLLGCCYEDEE 99 Query: 84 IYIVLEFVTGGELFDRIVHK--GRLEESESRKYFQQLVDAVAHCHCKG-VYHRDLKPENL 140 ++ EF+ L + H ++ + + + A+ +C KG + DL + Sbjct: 100 RLLIAEFMPNETLAKHLFHWESQPMKWAMRLRVALHIAQALEYCTSKGRALYHDLNAYRV 159 Query: 141 LLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSAADIWSCGVIL 200 L D + N ++S FGL ++G TP PE L G + I+S G +L Sbjct: 160 LFDDDANPRLSCFGLMKNSRDGKSYSTNLAFTP----PEYLR-TGRVTPESVIYSFGTLL 214 Query: 201 FVILAGY--LP------FSETDLPGLYRKINAAEFSCPPWFSAEVKFLIH---RILDPNP 249 +L+G P + ++ L +FS S + LI R L P Sbjct: 215 LDLLSGKHIPPSHALDLIRDRNIQMLMDSGLEGQFS-----SDDGTELIRLASRCLQYEP 269 Query: 250 KTRI 253 + R Sbjct: 270 RERP 273 >4L68-A nrPDB Length = 340 Score = 114 bits (286), Expect = 7e-26, Method: Composition-based stats. Identities = 36/192 (18%), Positives = 78/192 (40%), Gaps = 14/192 (7%) Query: 23 AKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYEVLASPS 82 A G +A+K ++ + + + + E++ + +RH N+ L Sbjct: 54 GTTYKA-LLPDGSALAVKHLSTCKLGE----REFRYEMNQLWELRHSNLAPLLGFCVVEE 108 Query: 83 KIYIVLEFVTGGELFDRI-VHKGRLEESESRKYFQQLVDAVAHCHC---KGVYHRDLKPE 138 + ++V ++++ G L + ++G L+ S + +A H + H+++ Sbjct: 109 EKFLVYKYMSNGTLHSLLDSNRGELDWSTRFRIGLGAARGLAWLHHGCRPPILHQNICSS 168 Query: 139 NLLLDTNGNLKVSDFGLSALPQEGV----ELLRTTCGTPNYVAPEVLSGQGYDGSAADIW 194 +L+D + + ++ D GL+ L + G YVAPE S D++ Sbjct: 169 VILIDEDFDARIIDSGLARLMVPSDNNESSFMTGDLGEFGYVAPE-YSTTMLASLKGDVY 227 Query: 195 SCGVILFVILAG 206 GV+L + G Sbjct: 228 GLGVVLLELATG 239 >6EQI-C nrPDB Length = 433 Score = 113 bits (282), Expect = 2e-25, Method: Composition-based stats. Identities = 57/323 (17%), Positives = 113/323 (34%), Gaps = 73/323 (22%) Query: 4 KMRRVGKYEVGRTIGEGTFAKVKFARNTDTG-----DNVAIKIMAKSTILKNRM--VDQI 56 + + + ++G I +G A V A+ + +A+K+M + N + + Sbjct: 10 QAANLDELDLGEPIAKGCNAVVYSAKLKNVQSNKLAHQLAVKMMFNYDVESNSTAILKAM 69 Query: 57 KRE---------------ISIMKIVR-----HPNIVRLYEVLASPSK------------- 83 RE I + + HPNIVR+Y V A Sbjct: 70 YRETVPAMSYFFNQNLFNIENISDFKIRLPPHPNIVRMYSVFADRIPDLQCNKQLYPEAL 129 Query: 84 --------------IYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKG 129 +++V+ + S QL++AVAH + Sbjct: 130 PPRINPEGSGRNMSLFLVM--KRYDCTLKEYLRDKTPNMRSSILLLSQLLEAVAHMNIHN 187 Query: 130 VYHRDLKPENLLL-----DTNGNLKVSDFGLSALPQEGVELL------RTTCGTPNYVAP 178 + HRDLK +N+L+ D + ++DFG ++ ++ + G +AP Sbjct: 188 ISHRDLKSDNILVDLSEGDAYPTIVITDFGCCLCDKQNGLVIPYRSEDQDKGGNRALMAP 247 Query: 179 EVLSGQG-----YDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFS-CPPW 232 E+ + + + +D+W+ G I + I PF + + L + + P Sbjct: 248 EIANAKPGTFSWLNYKKSDLWAVGAIAYEIFNIDNPFYDKTMKLLSKSYKEEDLPELPDT 307 Query: 233 FSAEVKFLIHRILDPNPKTRIQI 255 ++ L+ +L + R+ Sbjct: 308 IPFIIRNLVSNMLSRSTNKRLDC 330 >5UV4-A nrPDB Length = 311 Score = 110 bits (275), Expect = 1e-24, Method: Composition-based stats. Identities = 41/205 (20%), Positives = 79/205 (38%), Gaps = 15/205 (7%) Query: 15 RTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRL 74 IG A D G + +K + + + + REI + VRHPN+V L Sbjct: 31 EIIGRSCHGTSYKAT-LDNGYMLTVKWLKEGFAKSKK---EFSREIKKLGSVRHPNLVPL 86 Query: 75 YEVLASPSKI--YIVLEFVTGGELFDRI-----VHKGRLEESESRKYFQQLVDAVAHCHC 127 P + ++ ++ L + + L + + + + H Sbjct: 87 RGYYWGPKEHERIMISDYADATSLSTYLSEFDERNLPPLSAGQRLNIAIDIARCLDYLHN 146 Query: 128 KGVY-HRDLKPENLLL-DTNGNLKVSDFGLSALPQE-GVELLRTTCGTPNYVAPE-VLSG 183 + V H ++K N+L+ ++ + V+D+ L L G+ G Y PE + Sbjct: 147 ERVIPHGNIKSSNVLIQNSTPSALVTDYSLHRLMTPIGMAEQVLNAGALGYSPPEFSSTS 206 Query: 184 QGYDGSAADIWSCGVILFVILAGYL 208 + +D+++ GVIL +L G + Sbjct: 207 KPCPSLKSDVYAFGVILLELLTGKI 231 >4OAU-C nrPDB Length = 699 Score = 104 bits (260), Expect = 8e-23, Method: Composition-based stats. Identities = 52/238 (21%), Positives = 92/238 (38%), Gaps = 44/238 (18%) Query: 34 GDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR-HPNIVRLYEVLASPSKIYIVLEFVT 92 VA+K + + + +RE+S ++ R + ++V Y + +++ + Sbjct: 366 KQEVAVKTFCEGS-------PRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCE 418 Query: 93 GGELFDRIVHKGRLEESE----SRKYFQQLVDAVAHCH-CKGVYHRDLKPENLLLDTNGN 147 VH+G E+E +R + AV H G H+DL+P+N+L+D+ Sbjct: 419 QTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKA 478 Query: 148 LKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSAADIWSCG-VILFVILAG 206 ++DF S G P EV D+ G ++L+V+ G Sbjct: 479 AHLADFDKSIK----------WAGDPQ----EV---------KRDLEDLGRLVLYVVKKG 515 Query: 207 YLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWF 264 + F + L + N P E K LIHR+ P R + + P+F Sbjct: 516 SISFED-----LKAQSNEEVVQLSP--DEETKDLIHRLFHPGEHVRDCLSDLLGHPFF 566 >4O1O-A nrPDB Length = 717 Score = 101 bits (251), Expect = 9e-22, Method: Composition-based stats. Identities = 48/272 (17%), Positives = 101/272 (37%), Gaps = 52/272 (19%) Query: 23 AKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR-HPNIVRLYEVLASP 81 + D VA+K ++ + ++E+S ++ R + N+V Y + Sbjct: 360 GGIYLGLYED--QEVAVKRFSEGSTRG-------QQEVSCLQSSRANDNVVTFYGSESDG 410 Query: 82 SKIYIVLEFVTGGELFDRIVHK-----GRLEESESRKYFQQLVDAVAHCHCKGVYHRDLK 136 S +++ L L + + + E+ +R L A+ H G H+DL+ Sbjct: 411 SCLHVCLALCEY-TLQEHLANHRGDAVPNEEDESARNILSSLFKAIGELHRSGYSHQDLQ 469 Query: 137 PENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSAADIWSC 196 P+N+L+D+ ++DF S E + ++ D+ + Sbjct: 470 PQNILIDSKNGTFLADFDKSIKWAEDPQKIKR-----------------------DLEAL 506 Query: 197 G-VILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILDP--NPKTRI 253 G ++L+V+ G + F + ++ E + LIH + P N + R+ Sbjct: 507 GLLVLYVVKKGDISFETLKNQS-FEEVIQGSPD------EETRDLIHHLFHPGDNVEDRL 559 Query: 254 QIQGIKKDPWFRLNYVPIRAREEEEVNLDDIR 285 + P+F ++ + N DI+ Sbjct: 560 S--SLLAHPFFW-SWESRYRTLRDVGNESDIK 588 >5CLR-A nrPDB Length = 451 Score = 94.2 bits (233), Expect = 1e-19, Method: Composition-based stats. Identities = 46/238 (19%), Positives = 85/238 (35%), Gaps = 32/238 (13%) Query: 26 KFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYEVLASPSK-- 83 D G +K + + + + E + + RL + Sbjct: 96 FKVYALDDGKTYFLKSVK----IDAESLTEFTNEKDTLSKLG-----RLVGTFFNEQTQV 146 Query: 84 IYIVLEFVTGGELFDRIVHKGRLEES-------ESRKYFQQLVDAVAHCHCKGVYHRDLK 136 YI+ F+ G +L +K L + E + V H G+ HRDLK Sbjct: 147 HYILTTFIKGIDLS---RYKNALPLNVNLKHFWEVLGIMISVCHQVKQFHELGLIHRDLK 203 Query: 137 PENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGY--DGSAADIW 194 P N++LD + + DFG S+ +E + GT +Y+APE+ + + + +D++ Sbjct: 204 PGNIMLDADMQCHLVDFGSSSSDKEPKPA---SWGTASYLAPELNAQEDFIAFSQVSDLF 260 Query: 195 SCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILDPNPKTR 252 + L + PF + + I AE++ I ++ R Sbjct: 261 ALAYSLDELFN---PFRQVKFAKVDIGIKNKHLVL---LHAEIEACITGLMSNETSVR 312 >5UU1-A nrPDB Length = 324 Score = 91.5 bits (226), Expect = 6e-19, Method: Composition-based stats. Identities = 46/230 (20%), Positives = 87/230 (37%), Gaps = 28/230 (12%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVA---IKIMAKSTIL---------KNRMVDQI 56 ++ +G+ IG G F + A T+ + A +K+ + + D I Sbjct: 16 NQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDCI 75 Query: 57 KREISIMKIVRHPNIVRLYEV----LASPSKIYIVLEFVTGGELFDRIVHKGRLEESESR 112 K+ I K + + I Y S ++V+E + G +L G ++S Sbjct: 76 KKWIER-KQLDYLGIPLFYGSGLTEFKGRSYRFMVMERL-GIDLQKISGQNGTFKKSTVL 133 Query: 113 KYFQQLVDAVAHCHCKGVYHRDLKPENLLLD--TNGNLKVSDFGLSALP-------QEGV 163 + +++D + + H H D+K NLLL + ++D+GLS Q Sbjct: 134 QLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNGNHKQYQE 193 Query: 164 ELLRTTCGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSET 213 + GT + + + G +D+ G + L G LP+ + Sbjct: 194 NPRKGHNGTIEFTSLDAHKGVA-LSRRSDVEILGYCMLRWLCGKLPWEQN 242 >6EAS-A nrPDB Length = 308 Score = 86.1 bits (212), Expect = 3e-17, Method: Composition-based stats. Identities = 44/263 (16%), Positives = 89/263 (33%), Gaps = 39/263 (14%) Query: 20 GTFAKVKFARNT-DTGDNVAIK--IMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYE 76 G+ + + T +G +A+ ++ + Q +++I+ + V H N + L Sbjct: 49 GSTSTCMLYKGTLSSGVEIAVASSLVTSAKDWSKENESQYRKKITNLSKVSHKNFMNLLG 108 Query: 77 VLASPSKI--YIVLEFVTGGELFDRI--VHKGRLEESESRKYFQQLVDAVAHCHCKGV-- 130 +V E+ G LF+ + +L+ + + + H H Sbjct: 109 YCEEEHPFTRVMVFEYAPNGTLFEHLHVREAEKLDWMARLRISMGIAYCLEHMHQLQTPA 168 Query: 131 YHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAP--EVLSGQGYDG 188 R+ + L + KVSD + +P E + + Sbjct: 169 ALRNFDSTTVYLTDDFAAKVSDLEFWNDAKGHNSTTNNELAF----SPDMEDIVRK---- 220 Query: 189 SAADIWSCGVILFVILAGYLPFSETDLP-------------GLYRKINAAEFSCPPWFSA 235 G++L IL G +P SE D P L I+ + P + Sbjct: 221 -------YGMVLLEILTGRVPSSEDDGPLENWVSRYFEGGMRLEELIDPSIGFFPEDTAR 273 Query: 236 EVKFLIHRILDPNPKTRIQIQGI 258 + ++ +D +PK R Q++ + Sbjct: 274 ALCEVVRSCIDRDPKKRPQMKEV 296 >4IX6-A nrPDB Length = 350 Score = 82.6 bits (203), Expect = 3e-16, Method: Composition-based stats. Identities = 54/319 (16%), Positives = 100/319 (31%), Gaps = 77/319 (24%) Query: 16 TIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN----I 71 +G G F V D V + + + ++ E+ + V H N Sbjct: 27 PLGSGNFGTVFRGVFKGDQDVV----LKNAKADVMAAEELLECEMDVNYHV-HANAKGTC 81 Query: 72 VRLYEVLASPSK-------------IYIVLEFVTGGELFDRIVHKGRLEESES------- 111 R + +K +++ + G + ++ +G + + Sbjct: 82 ARFMGCIELGAKDGGEIYNGTLTEGLWL-MWANEGENTVEALMRRGTAPLATAMACADAT 140 Query: 112 -----RKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTN--GNLKVSDFGLSALPQEGVE 164 +K ++L+ ++A H GV HRD+KP NL+ G LK+ D G +AL E Sbjct: 141 ELGVTKKAMRELLGSLARLHECGVVHRDVKPANLIAAEKDGGVLKLIDLGAAALCLPLPE 200 Query: 165 LLRTTCG----TPNYV-APEVLSGQGYDGSAA----------------DIWSCGVILFVI 203 L G P Y A E+ D WS G ++ + Sbjct: 201 TLNYYPGDGPADPRYAKADELYLLPPGSPRPTKDNAAKLWEAHKPDRFDSWSAGCVMLQL 260 Query: 204 LA-------GYLPFS------ETDLPGLYRKINAAEFSCPPWFSAEV-----KFLIHRIL 245 G F D+ +R + E+ + + + L R++ Sbjct: 261 AVVGLRTDAGLERFLADYKAVGYDVNA-FRGEKSGEYGTMDFAALDANGGAGWDLCQRLM 319 Query: 246 DPNPKTRIQIQGIKKDPWF 264 + R + +F Sbjct: 320 EAERDARASCEAALSHAFF 338 >2RSV-A nrPDB Length = 403 Score = 79.9 bits (196), Expect = 2e-15, Method: Composition-based stats. Identities = 42/278 (15%), Positives = 99/278 (35%), Gaps = 52/278 (18%) Query: 1 MTKKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNV------AIKIMAKS--------- 45 M KK +++VG IG+G F + A + ++ ++V +K+ Sbjct: 39 MAKK-----EWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELK 92 Query: 46 ---TILKNRMVDQIKREISIMKIVRHPNIVRLYEVLASP----SKIYIVLEFVTGGELFD 98 K + + R + +++ + + + S +++++ G Sbjct: 93 FYQRAAKPEQIQKWIR----TRKLKYLGVPKYWGSGLHDKNGKSYRFMIMD--RFGSDLQ 146 Query: 99 RI--VHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLLD--TNGNLKVSDFG 154 +I + R + +++D + + H H D+K NLLL+ + + D+G Sbjct: 147 KIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYG 206 Query: 155 LSALP-------QEGVELLRTTCGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGY 207 L+ + + R GT + + + +G D+ G + L G+ Sbjct: 207 LAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVA-PSRRGDLEILGYCMIQWLTGH 265 Query: 208 LPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRIL 245 LP+ + Y + + + + L+ + Sbjct: 266 LPWEDNLKDPKYVRDSKIRYR------ENIASLMDKCF 297 >2LAV-A nrPDB Length = 361 Score = 79.5 bits (195), Expect = 3e-15, Method: Composition-based stats. Identities = 42/278 (15%), Positives = 99/278 (35%), Gaps = 52/278 (18%) Query: 1 MTKKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNV------AIKIMAKS--------- 45 M KK +++VG IG+G F + A + ++ ++V +K+ Sbjct: 32 MAKK-----EWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELK 85 Query: 46 ---TILKNRMVDQIKREISIMKIVRHPNIVRLYEVLASP----SKIYIVLEFVTGGELFD 98 K + + R + +++ + + + S +++++ G Sbjct: 86 FYQRAAKPEQIQKWIR----TRKLKYLGVPKYWGSGLHDKNGKSYRFMIMD--RFGSDLQ 139 Query: 99 RI--VHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLLD--TNGNLKVSDFG 154 +I + R + +++D + + H H D+K NLLL+ + + D+G Sbjct: 140 KIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYG 199 Query: 155 LSALP-------QEGVELLRTTCGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGY 207 L+ + + R GT + + + +G D+ G + L G+ Sbjct: 200 LAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVA-PSRRGDLEILGYCMIQWLTGH 258 Query: 208 LPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRIL 245 LP+ + Y + + + + L+ + Sbjct: 259 LPWEDNLKDPKYVRDSKIRYR------ENIASLMDKCF 290 >5DMZ-A nrPDB Length = 365 Score = 76.1 bits (186), Expect = 3e-14, Method: Composition-based stats. Identities = 41/272 (15%), Positives = 90/272 (33%), Gaps = 41/272 (15%) Query: 13 VGRTIGEGTFAKVKFAR-----NTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR 67 V +GEG FA+V A + +K+ + + + Q+ + ++ Sbjct: 69 VHHLLGEGAFAQVYEATQGDLNDAKNKQKFVLKVQKPANPWEFYIGTQLME--RLKPSMQ 126 Query: 68 HPNIVRLYEVLASPSKIYIVLEFVTGGELFDRI-----VHKGRLEESESRKYFQQLVDAV 122 H ++ Y + +V E + G L + I + + + + +++ + Sbjct: 127 HMF-MKFYSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEKVMPQGLVISFAMRMLYMI 185 Query: 123 AHCHCKGVYHRDLKPENLLL-----------DTNGNLKVSDFGLSALPQ--EGVELLRTT 169 H + H D+KP+N +L D + L + D G S + + Sbjct: 186 EQVHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMKLFPKGTIFTAK 245 Query: 170 CGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYL--------------PFSETDL 215 C T + E+LS + ++ D + ++ +L G F Sbjct: 246 CETSGFQCVEMLSNKPWN-YQIDYFGVAATVYCMLFGTYMKVKNEGGECKPEGLFRRLPH 304 Query: 216 PGLYRKINAAEFSCPPWFSAEVKFLIHRILDP 247 ++ + + P L+ + L Sbjct: 305 LDMWNEFFHVMLNIPDCHHLPSLDLLRQKLKK 336 >6G4J-A nrPDB Length = 315 Score = 73.8 bits (180), Expect = 2e-13, Method: Composition-based stats. Identities = 37/206 (17%), Positives = 73/206 (35%), Gaps = 37/206 (17%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 Y + + +G+G V A +D VA+K+ + I E++++K Sbjct: 28 YTLRKQLGKGANGIVYLAETSDGH--VALKV--------SDDSLSITSEVNVLKSFSKAQ 77 Query: 71 IVRLYEVLASPSKIYI----------VLEFVTGGELFDRIVHKGRLEESESRKYFQQLVD 120 V + YI +E++ G L + KG QL+ Sbjct: 78 SVTMGPSFFDTDDAYIPSANTKVSFYAMEYIKGPLLLKYVSDKGA---EWIPVLMIQLLS 134 Query: 121 AVAHCHCKGVYHRDLKPENLLLD-TNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPE 179 +++ H +G DLKP+NL++ ++ D G + ++ + Sbjct: 135 SLSVLHQQGWIFGDLKPDNLIVTGPPARIRCIDVGGTTKEGRAIKEYTEFYDRGYW---- 190 Query: 180 VLSGQGYDGSAA----DIWSCGVILF 201 GY A D+++ +I+ Sbjct: 191 -----GYGTRKAEPSYDLFAVAMIMI 211 >6EWX-A nrPDB Length = 484 Score = 72.2 bits (176), Expect = 4e-13, Method: Composition-based stats. Identities = 40/196 (20%), Positives = 68/196 (34%), Gaps = 46/196 (23%) Query: 108 ESESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLL-----------DTNGNLK------- 149 E QL + + H G+ HRDL ENLLL N ++ Sbjct: 209 ERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLVHCNPQSSPGPSANPSVPTTTSRCP 268 Query: 150 -----------------------VSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGY 186 +S+F + G L+ +APE++S Y Sbjct: 269 SAAPAATTACQGGPGEKHLPRLIISNFLKAKQKPGGTTNLQQKKSQAR-LAPEIVSASQY 327 Query: 187 DGSAADIWSCGVILFVILAGYLPFS--ETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRI 244 D + G++++ +L PF YR+ + +S ++ L H + Sbjct: 328 --RKFDEFQTGILIYELLHQPNPFEVRAQLRERDYRREDLPPLPTLSLYSPGLQQLAHLL 385 Query: 245 LDPNPKTRIQIQGIKK 260 L+ +P RI+I K+ Sbjct: 386 LEADPIKRIRIGEAKR 401 >6BHC-A nrPDB Length = 438 Score = 69.5 bits (169), Expect = 3e-12, Method: Composition-based stats. Identities = 55/271 (20%), Positives = 88/271 (32%), Gaps = 55/271 (20%) Query: 36 NVAIKIMAKSTILKNRM------VDQIKREISIMKIVRH-----PNIVRLYEVL----AS 80 N A+KI + + +I + H PN RL Sbjct: 85 NYAVKICKSKAKESQQYYHSLAVRQSLAVHFNIQQDCGHFLAEVPN--RLLPWEDPSKKQ 142 Query: 81 PSKIYIVLEFVTGGELFDRIV-------HKGRLEESESRKYFQQLVDAVAHCHCKGVYHR 133 S + ++ V + D + L E + QL + H V H Sbjct: 143 RSHVVVITREVPCLTVADFVRDSLAQHGKSPDLYERQVCLLLLQLCSGLEHLKPYHVTHC 202 Query: 134 DLKPENLLL---------------------DTNGNLKVSDFGLSALPQE--GVELLRTTC 170 DL+ ENLLL L VS+F + E+LR Sbjct: 203 DLRLENLLLVHYQPGGTAQGFGPAEPTPTSSYPTRLIVSNFSQAKQKSHLVDPEILRDQS 262 Query: 171 GTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDL--PGLYRKINAAEFS 228 +APE+++ Y D + G++++ +L PF E Y + + Sbjct: 263 R----LAPEIITATQY--KKCDEFQTGILIYEMLHLPNPFDENPELKEREYTRADLPRIP 316 Query: 229 CPPWFSAEVKFLIHRILDPNPKTRIQIQGIK 259 +S ++ L +L+PNP RI I K Sbjct: 317 FRSPYSRGLQQLASCLLNPNPSERILISDAK 347 >6M7Z-A nrPDB Length = 319 Score = 66.8 bits (162), Expect = 2e-11, Method: Composition-based stats. Identities = 35/204 (17%), Positives = 68/204 (33%), Gaps = 22/204 (10%) Query: 87 VLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNG 146 + ++ G + D + + + +V A+ H G+ HR ++ + + +G Sbjct: 124 IFHPLSKGLVGDMLETGR--SHPDVQVLAANMVAALKSLHNLGLLHRSIELNSFSVLPDG 181 Query: 147 NLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEV--------LSGQGYDGSAADIWSCGV 198 + + +A L G APE+ QG +D++S GV Sbjct: 182 TVVLGGLDTAAPIGTETRLWVGFFG--QETAPEIDRNFLADLALTQGRHTVKSDVYSLGV 239 Query: 199 ILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILDPNPKTRIQIQGI 258 ++ L + P + S ++++ P R I+ I Sbjct: 240 AFRNLV--QLLGNGNLGPEDRGAVRQDHLELLDKLSQ-------KMIEEEPGNRPTIEEI 290 Query: 259 KKDPWFR-LNYVPIRAREEEEVNL 281 KDP F LN+ I + Sbjct: 291 MKDPLFEGLNFEDIEEGKARPFRY 314 >4CI6-B nrPDB Length = 643 Score = 66.8 bits (162), Expect = 2e-11, Method: Composition-based stats. Identities = 47/275 (17%), Positives = 92/275 (33%), Gaps = 52/275 (18%) Query: 31 TDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIV-----RHPNIVRLYE--VLASPSK 83 D VA I ++ + E+ K + +HPN+ ++ V+ ++ Sbjct: 66 KDKQRLVA-------KIERSIAEGHLFAELEAYKHIYKTAGKHPNLANVHGMAVVPYGNR 118 Query: 84 IY--IVLEFVTG-------GELFDRIVHKGRLEES---ESRKYFQQLVDAVAHCHCKGVY 131 Y ++++ V G L D E+ + +L+D H G+ Sbjct: 119 YYYALLMDEVDGWRCSDTLRSLADSWKQGKINSEAYWGTIKFIAHRLLDVTNHLAKAGIV 178 Query: 132 HRDLKPENLLLD-TNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSA 190 H D+KP N++ D +G V D GL + E + T ++ APE+ G Sbjct: 179 HNDIKPGNVVFDRASGEPVVIDLGLHSRSGEQPKGF-----TESFKAPELGVGNLGASEK 233 Query: 191 ADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAE-------------- 236 +D++ +++ +L G F + + + P E Sbjct: 234 SDVF---LVVSTLLHGIEGFEKDPEIKPNQGLRFITSE-PAHVMDENGYPIHRPGIAGVE 289 Query: 237 --VKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYV 269 I IL + +R + + + Sbjct: 290 TAYTRFITDILGVSADSRPDSNEARLHEFLSDGTI 324 >5GZA-A nrPDB Length = 290 Score = 65.7 bits (159), Expect = 4e-11, Method: Composition-based stats. Identities = 43/214 (20%), Positives = 76/214 (35%), Gaps = 44/214 (20%) Query: 12 EVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNI 71 + IG+G KV + G VA+ +++ ++ D +S+++ ++ ++ Sbjct: 28 RRVKLIGQGAVKKVYLSEW--QGQKVALSVLS-----SDQYADDFLHGLSMLRALQSSHV 80 Query: 72 VRLYEVLASPSKIYIVLEFVTGGELFDRI------VHKGRLEESESRKYFQQLVDAVAHC 125 V L V + V E+ G + ++ R + V +A+ Sbjct: 81 VTLVGVCEEDA--VFVTEYHPLGSVLTLDTTLAQERYRWRNSWHTRLQLAIDYVAFLAYL 138 Query: 126 HCK--GV--------YHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCG---- 171 H G+ H+ L LL ++ L +D L ALP+ L CG Sbjct: 139 HSSPAGIRVMCDSNDLHKTL--SQFLLASDMRLLAND--LDALPEVEKGGLGVKCGHHEL 194 Query: 172 TPNYVAPEVL-----------SGQGYDGSAADIW 194 T ++VAPE L DIW Sbjct: 195 TGDFVAPEQLWPYGEDFSFSDEAMPGYDEKTDIW 228 >5VE6-A nrPDB Length = 492 Score = 65.3 bits (158), Expect = 5e-11, Method: Composition-based stats. Identities = 40/210 (19%), Positives = 70/210 (33%), Gaps = 64/210 (30%) Query: 108 ESESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLK------------------ 149 E QL + + H G+ HRDL EN LL + L+ Sbjct: 207 ERRVCFLLLQLCNGLEHLKEHGIIHRDLCLEN-LLLVHCTLQAGPGPAPAPAPAPAAAAP 265 Query: 150 ----------------------------------VSDFGLSALPQEGVELLRTTCGTPNY 175 +S+F + G L+ Sbjct: 266 PCSSAAPPAGGTLSPAAGPASPEGPREKQLPRLIISNFLKAKQKPGGTPNLQQKKSQAR- 324 Query: 176 VAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPW--- 232 +APE++S Y D + G++++ +L PF + R+ + + PP Sbjct: 325 LAPEIVSASQY--RKFDEFQTGILIYELLHQPNPFE---VRAQLRERDYRQEDLPPLPAL 379 Query: 233 --FSAEVKFLIHRILDPNPKTRIQIQGIKK 260 +S ++ L H +L+ +P RI+I K+ Sbjct: 380 SLYSPGLQQLAHLLLEADPIKRIRIGEAKR 409 >5GZ9-A nrPDB Length = 305 Score = 64.1 bits (155), Expect = 1e-10, Method: Composition-based stats. Identities = 35/210 (16%), Positives = 69/210 (32%), Gaps = 39/210 (18%) Query: 14 GRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVR 73 + +GEG +V + + VA+ S + + M + + ++K ++ ++V Sbjct: 39 LKRVGEGAVKRVFLSEWKE--HKVAL-----SRLTRLEMKEDFLHGLQMLKSLQSEHVVT 91 Query: 74 LYEVLASPSKIYIVLEFVTGGEL------FDRIVHKGRLEESESRKYFQQLVDAVAHCHC 127 L I+ E+ G L ++ + + V + + H Sbjct: 92 LVGYCEEDGT--ILTEYHPLGSLSNLEETLQLSKYQDVNTWQHRLQLAMEYVSIINYLHH 149 Query: 128 KGVYHRDLKPEN--------LLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPN----Y 175 + R + N LL +N ++ +D + + + CG + Sbjct: 150 SPLGTRVMCDSNDLPKTLSQYLLTSNFSIVANDLD-ALPLVDHDSGVLIKCGHRELHGDF 208 Query: 176 VAPEVLSGQGYDGS-----------AADIW 194 VAPE L G D DIW Sbjct: 209 VAPEQLWPYGEDTPFQDDLMPSYNEKVDIW 238 >2JII-A nrPDB Length = 352 Score = 57.6 bits (138), Expect = 1e-08, Method: Composition-based stats. Identities = 24/119 (20%), Positives = 48/119 (40%), Gaps = 14/119 (11%) Query: 103 KGRLEESESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLLD--TNGNLKVSDFGLSALPQ 160 K L E + +L+DA+ H H ++ EN+ +D + ++ +G + Sbjct: 153 KHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVDPEDQSQVTLAGYGFAFRYC 212 Query: 161 EGVELLRTTCGTPNYVAP-----EVLSGQGYDG----SAADIWSCGVILFVILAGYLPF 210 + + G+ +P E +S + G +D+ S G + L G+LP+ Sbjct: 213 PSGKHVAYVEGS---RSPHEGDLEFISMDLHKGCGPSRRSDLQSLGYCMLKWLYGFLPW 268 >4AZW-A nrPDB Length = 471 Score = 55.6 bits (133), Expect = 5e-08, Method: Composition-based stats. Identities = 20/70 (28%), Positives = 38/70 (54%), Gaps = 3/70 (4%) Query: 85 YIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDT 144 ++V+E + G L D + EE + K L+ ++A KG +H D++P N+++D Sbjct: 318 WLVMEKLPGRLLSDMLAAG---EEIDREKILGSLLRSLAALEKKGFWHDDVRPWNVMVDA 374 Query: 145 NGNLKVSDFG 154 + ++ DFG Sbjct: 375 RQHARLIDFG 384 >4AZV-A nrPDB Length = 569 Score = 54.9 bits (131), Expect = 6e-08, Method: Composition-based stats. Identities = 19/70 (27%), Positives = 38/70 (54%), Gaps = 3/70 (4%) Query: 85 YIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDT 144 ++V+E + G L D + EE + K L+ ++A +G +H D++P N+++D Sbjct: 318 WLVMEKLPGRLLSDMLAAG---EEIDREKILGSLLRSLAALEKQGFWHDDVRPWNVMVDA 374 Query: 145 NGNLKVSDFG 154 + ++ DFG Sbjct: 375 RQHARLIDFG 384 >3ENH-A nrPDB Length = 540 Score = 53.3 bits (127), Expect = 2e-07, Method: Composition-based stats. Identities = 34/164 (20%), Positives = 62/164 (37%), Gaps = 27/164 (16%) Query: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIK-----REISIMKIVRH--- 68 IG+G A +K R++ +V IK K R+ + I+ RE + +V+ Sbjct: 344 IGKGAEADIK--RDSYLDFDVIIKERVKKGYRDERLDENIRKSRTAREARYLALVKDFGI 401 Query: 69 --PNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCH 126 P I ++V +I + ++ G+L ++ ++ + V H Sbjct: 402 PAPYI---FDVDLDNKRIM--MSYI-NGKLAKDVIEDN-------LDIAYKIGEIVGKLH 448 Query: 127 CKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTC 170 V H DL N + D + L + DFGL + + Sbjct: 449 KNDVIHNDLTTSNFIFDKD--LYIIDFGLGKISNLDEDKAVDLI 490 >3BYV-A nrPDB Length = 377 Score = 53.0 bits (126), Expect = 2e-07, Method: Composition-based stats. Identities = 34/187 (18%), Positives = 73/187 (39%), Gaps = 24/187 (12%) Query: 90 FVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLK 149 ++ +VH RL + Q++ +A H G+ H L+P +++LD G + Sbjct: 193 LLSHSSTHKSLVHHARL------QLTLQVIRLLASLHHYGLVHTYLRPVDIVLDQRGGVF 246 Query: 150 VSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQ---GYD-------GSAADIWSCGVI 199 ++ G L ++G ++ + + + PE+ + + Y + D W+ G++ Sbjct: 247 LT--GFEHLVRDGARVVSSV--SRGFEPPELEARRATISYHRDRRTLMTFSFDAWALGLV 302 Query: 200 LFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILDPNPKTRIQIQGIK 259 ++ I LP ++ G I F V+ L+ L + R+ Sbjct: 303 IYWIWCADLPITKDAALGGSEWI----FRSCKNIPQPVRALLEGFLRYPKEDRLLPLQAM 358 Query: 260 KDPWFRL 266 + P + Sbjct: 359 ETPEYEQ 365 >4CZY-B nrPDB Length = 429 Score = 51.8 bits (123), Expect = 6e-07, Method: Composition-based stats. Identities = 43/286 (15%), Positives = 106/286 (37%), Gaps = 52/286 (18%) Query: 26 KFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYEVLAS----P 81 A+N G + A++ + + + + + +E K + + NIV ++E + Sbjct: 61 YKAQNNKNGRHFALRRIEGYRLTNEKAILNVTKE---WKKIINANIVTVHEAFTTEFFGD 117 Query: 82 SKIYIVLEFVTGGE-LFDR----------IVHKGRLEESESRKYFQQLVDAVAHCHCKGV 130 S + V +F E L+D + + ++ E+ Y Q+ +A+ H + Sbjct: 118 SSLIFVYDFHPLSETLYDHHFPPNNSHNRLRNTNKIPENLLWSYVCQIANALLAIHNAKL 177 Query: 131 YHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSA 190 R L+ + + N ++++ + + +T E L + + Sbjct: 178 AARCLELSKI-IWENNRIRLAACSILDVLHHDSPNRKTI---------EELQQEDFVK-- 225 Query: 191 ADIWSCGVILFVILAGYLPFSETDLPGL-YRKINAAEFSCPPWFSAEVKFLIHRILDPN- 248 G I+ + + P L + I+AA + P +S +++ ++ ++ P+ Sbjct: 226 -----FGRIILALAT--------NTPTLNFNNIDAALATIVPRYSTQLRGVLEWLIKPSA 272 Query: 249 PKTRIQIQGIKK----DPWFRLNYVPIRAREEEEVNLDDIRAVFDG 290 P ++ + N+ +E +E +R + +G Sbjct: 273 PGETKTVETLLGGITTH---LANFANFVMQESDEKEFHLMRELENG 315 >3L19-A nrPDB Length = 214 Score = 51.4 bits (122), Expect = 7e-07, Method: Composition-based stats. Identities = 13/96 (13%), Positives = 41/96 (42%), Gaps = 14/96 (14%) Query: 283 DIRAVFDGIEGSYVAENVERNDEGPLMMNAFEMITLSQGLNLSALFD----------RRQ 332 ++ ++ + IE +N ++ + L+ A ++ + + L+ +F RQ Sbjct: 24 ELPSLANAIENMRKFQNSQKLAQAALLYMASKLTSQEETKELTDIFRHIDKNGDGQLDRQ 83 Query: 333 DFVKRQTRF----VSRREPSEIIANIEAVANSMGFK 364 + + ++ V+ + +I + ++A+ + F Sbjct: 84 ELIDGYSKLSGEEVAVFDLPQIESEVDAILGAADFD 119 >4CYJ-A nrPDB Length = 438 Score = 51.0 bits (121), Expect = 9e-07, Method: Composition-based stats. Identities = 23/141 (16%), Positives = 58/141 (41%), Gaps = 17/141 (12%) Query: 25 VKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYEVLAS---- 80 V A+N+ G + A++ + + + + + ++ K +++ +IV ++EV + Sbjct: 71 VYKAQNSRNGRHYALRRLEGYRLTNEKAILNVMKD---WKKIKNASIVTIHEVFTTREFG 127 Query: 81 PSKIYIVLEFVTGGELF----------DRIVHKGRLEESESRKYFQQLVDAVAHCHCKGV 130 S + +F + +R + E+ Y Q+ +A+ H + Sbjct: 128 DSSLIFAYDFHPLSKTLQEHHFQPIHGNRYRPPPAVPENTIWGYICQIANALKTIHSNRL 187 Query: 131 YHRDLKPENLLLDTNGNLKVS 151 R L+P ++L +++S Sbjct: 188 AARCLEPSKIILTDINRIRLS 208 >2W1Z-A nrPDB Length = 368 Score = 50.6 bits (120), Expect = 1e-06, Method: Composition-based stats. Identities = 33/177 (18%), Positives = 59/177 (33%), Gaps = 17/177 (9%) Query: 93 GGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSD 152 G L L + QL+ A G+ H D + N+LLD G + ++ Sbjct: 175 GDVLLSHSSTHKSLVHHARLQLTLQLIRLAASLQHYGLVHADFQVRNILLDQRGGVFLT- 233 Query: 153 FGLSALPQEGVELLRTTCGTPNYVAPE-----VLSGQGYD----GSAADIWSCGVILFVI 203 G L ++G + + G + PE +L + + D W+ G+ ++ I Sbjct: 234 -GFEHLVRDGASAV-SPIG-RGFAPPETTAERMLPYRQHHPTLMTFPFDTWTLGLAIYWI 290 Query: 204 LAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILDPNPKTRIQIQGIKK 260 LP I C V+ L+ L + + R+ + Sbjct: 291 WCADLP---NTEDAELGGIEWIYRRC-KNIPQPVRALLEGFLRYSKEDRLLPLQAME 343 >3DZO-A nrPDB Length = 413 Score = 49.5 bits (117), Expect = 3e-06, Method: Composition-based stats. Identities = 35/186 (18%), Positives = 69/186 (37%), Gaps = 23/186 (12%) Query: 90 FVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLK 149 ++ +VH RL + Q++ +A H G+ H L+P +++LD G + Sbjct: 198 LLSHSSTHKSLVHHARL------QLTLQVIRLLASLHHYGLVHTYLRPVDIVLDQRGGVF 251 Query: 150 VSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYD---------GSAADIWSCGVIL 200 ++ G L ++G + + G + PE + + A D W+ G+ + Sbjct: 252 LT--GFEHLVRDGASAV-SPIG-RGFAPPETTAERMLPFGQHHPTLMTFAFDTWTLGLAI 307 Query: 201 FVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILDPNPKTRIQIQGIKK 260 + I LP ++ G I F V+ L+ L + R+ + Sbjct: 308 YWIWCADLPNTDDAALGGSEWI----FRSCKNIPQPVRALLEGFLRYPKEDRLLPLQAME 363 Query: 261 DPWFRL 266 P + Sbjct: 364 TPEYEQ 369 >6G38-A nrPDB Length = 357 Score = 46.8 bits (110), Expect = 2e-05, Method: Composition-based stats. Identities = 36/177 (20%), Positives = 59/177 (33%), Gaps = 48/177 (27%) Query: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKS-----TILKNRMVDQIKREISIM 63 K + IGEG F +V + VAIKI+A + ++I EI I Sbjct: 41 EKLQRCEKIGEGVFGEVF--QTIADHTPVAIKIIAIEGPDLVNGSHQKTFEEILPEIIIS 98 Query: 64 KI-----------------VRHPNIVR------LYEV----------------LASPSKI 84 K + + V+ L + ++ Sbjct: 99 KELSLLSGEVCNRTEGFIGLNSVHCVQGSYPPLLLKAWDHYNSTKGSANDRPDFFKDDQL 158 Query: 85 YIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCH-CKGVYHRDLKPENL 140 +IVLEF GG +++ K + ++ QL ++A HRDL N+ Sbjct: 159 FIVLEFEFGGIDLEQMRTKLS-SLATAKSILHQLTASLAVAEASLRFEHRDLHWGNV 214 >4WWA-A nrPDB Length = 261 Score = 46.4 bits (109), Expect = 2e-05, Method: Composition-based stats. Identities = 23/151 (15%), Positives = 47/151 (31%), Gaps = 24/151 (15%) Query: 26 KFARNTDTGDNVAIKIMAKSTILKNRMVD-----QIKREISIMKIVRHPNIV------RL 74 R D+ IK ++ + E ++ + ++ +L Sbjct: 38 YLPRAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNESRLLAKL---YLIPGLCVPQL 94 Query: 75 YEVLASPSKIYIVL--EFVTGG----ELFDRI-VHKGRLEESESRKYFQQLVDAVAHCHC 127 I++ E + GG L + + +H +++ + H Sbjct: 95 IACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHW 154 Query: 128 KGVYHRDLKPENLLLDTNG---NLKVSDFGL 155 H DL N++L +G + DFGL Sbjct: 155 NDYCHGDLTSSNIVLVRDGARWTPHLIDFGL 185 >3Q60-A nrPDB Length = 371 Score = 45.6 bits (107), Expect = 4e-05, Method: Composition-based stats. Identities = 37/162 (22%), Positives = 61/162 (37%), Gaps = 15/162 (9%) Query: 114 YFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTP 173 QL+ A+ KG+ H P+NL + +G L + D +SAL + G ++ Sbjct: 199 LTAQLIRLAANLQSKGLVHGHFTPDNLFIMPDGRLMLGD--VSALWKVGTRGPASSV-PV 255 Query: 174 NYVAPEVLS-GQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPW 232 Y E L+ A + W G+ ++ + +LPF PG+ P Sbjct: 256 TYAPREFLNASTATFTHALNAWQLGLSIYRVWCLFLPF-GLVTPGIKGSWKRPSLRVPGT 314 Query: 233 ----------FSAEVKFLIHRILDPNPKTRIQIQGIKKDPWF 264 VK LI R L+ + + R+ + P F Sbjct: 315 DSLAFGSCTPLPDFVKTLIGRFLNFDRRRRLLPLEAMETPEF 356 >6R5K-O nrPDB Length = 689 Score = 42.2 bits (98), Expect = 4e-04, Method: Composition-based stats. Identities = 37/293 (12%), Positives = 101/293 (34%), Gaps = 31/293 (10%) Query: 26 KFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYEVLASPS--- 82 + G +K + I K+ ++I + I + N+++ ++ + Sbjct: 311 FKVFSNYDGKAYVLKRLPN--IDKSMNPNKISKIYQIWSKINCTNLIKFRDIFQTTKFGD 368 Query: 83 -KIYIVLEFVTGG-ELFDRI---VHKGRLEESESRKYFQQLVDAVAHCHCKGV-YHRDLK 136 I +V ++ L+D K + + Y QL + + H + + L Sbjct: 369 LSICLVFDYYPNSLSLYDYHFVNFPKFPITNNYLWIYLVQLTNVINSIHSQNLSIGNTLN 428 Query: 137 PENLLLDTN-GNLKV--SDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSAADI 193 +L+ + G +K+ +F + L + + + ++ G+ E Y Sbjct: 429 WRKVLITGDPGRIKLSHCNF-MDLLFNDDTDTVVSSGGST----IEGQQQLDYKY----- 478 Query: 194 WSCGVILFVILAGYLPFSETDLPGLYR--KINAAEFSCPPWFSAEVKFLIHRILDPNPKT 251 G +LF + + P YR +I + K ++ ++ N + Sbjct: 479 --LGELLFNLSINIENSNNNTAPKEYRLEEITPQSIDDMRQIDDKFKDVLKYLISDNGDS 536 Query: 252 RIQIQGIKKDPWFRLNYVPIRAREEEEVNLDDIRAVFDGIEGSYVAENVERND 304 + I + ++ ++ + + + ++ + + +E + V + + Sbjct: 537 KKSIHDLTSH-FYDKMFMVLESSQTYTEYMESV--LSRELENGRLFRLVNKLN 586 >1TQM-A nrPDB Length = 282 Score = 42.2 bits (98), Expect = 4e-04, Method: Composition-based stats. Identities = 25/155 (16%), Positives = 61/155 (39%), Gaps = 26/155 (16%) Query: 13 VGRTIGEGTFAKVKFARNTDTGDNVAI---------KIMAKSTILKNRM-----VDQIKR 58 +G+ +GEG + V + G+ V K + + + + + Sbjct: 94 IGKLMGEGKESAVFNCYSEKFGECVVKFHKVGHTSFKKVKEKRDYGDLHFSVLAIRSARN 153 Query: 59 EISIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQL 118 E ++ ++ + ++Y + +++E + EL+ R+ + + Sbjct: 154 EFRALQKLQGLAVPKVYAWEGNA----VLMELIDAKELY-------RVRVENPDEVLDMI 202 Query: 119 VDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDF 153 ++ VA + +G+ H DL N+L+ G + + DF Sbjct: 203 LEEVAKFYHRGIVHGDLSQYNVLVSEEG-IWIIDF 236 >4BWP-A nrPDB Length = 448 Score = 41.0 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 19/140 (13%), Positives = 42/140 (30%), Gaps = 39/140 (27%) Query: 26 KFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYEVLAS----P 81 A + TG ++ + + + + + K ++H N+V+L EV + Sbjct: 67 YRATHNTTGYKYCLRRIHGFRL----QSTKCMTLVEMWKKLQHTNVVQLREVFTTKAFGD 122 Query: 82 SKIYIVLEFVTGGE--LFDRIV-----------------------------HKGRLEESE 110 + + +V ++ G + L + L E+ Sbjct: 123 NSLVLVYDYHPGSQTLLAKYFTPAPETNGYTDPFQGEARPFSHKSNMQRTSNGPLLPEAT 182 Query: 111 SRKYFQQLVDAVAHCHCKGV 130 QL + H G+ Sbjct: 183 IWSIIMQLTAGLKAIHHAGL 202 >4XR7-L nrPDB Length = 465 Score = 41.0 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 21/136 (15%), Positives = 50/136 (36%), Gaps = 12/136 (8%) Query: 26 KFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYEVLASPSK-- 83 + G +K + I K+ ++I + I + N+++ ++ + Sbjct: 87 FKVFSNYDGKAYVLKRLPN--IDKSMNPNKISKIYQIWSKINCTNLIKFRDIFQTTKFGD 144 Query: 84 --IYIVLEFVTGG-ELFDRI---VHKGRLEESESRKYFQQLVDAVAHCHCKGV-YHRDLK 136 I +V ++ L+D K + + Y QL + + H + + L Sbjct: 145 LSICLVFDYYPNSLSLYDYHFVNFPKFPITNNYLWIYLVQLTNVINSIHSQNLSIGNTLN 204 Query: 137 PENLLLDTN-GNLKVS 151 +L+ + G +K+S Sbjct: 205 WRKVLITGDPGRIKLS 220 >4BVU-A nrPDB Length = 211 Score = 40.6 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 27/147 (18%), Positives = 51/147 (34%), Gaps = 23/147 (15%) Query: 13 VGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIV 72 +G+ IG+G+ A++ N + K N +++ +E + Sbjct: 44 LGKLIGQGSTAEIFEDVNDSSALY---KKYDLIGNQYNEILEMAWQESELFN-------- 92 Query: 73 RLYE-----VLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHC 127 Y V+ +Y+ + V G L D + + ++ Y Q + + Sbjct: 93 AFYGDEASVVIQYGGDVYLRMLRVPGTPLSD--IDTADIPDNIESLYLQLICK----LNE 146 Query: 128 KGVYHRDLKPENLLLDTNGN-LKVSDF 153 + H DL N+L D L DF Sbjct: 147 LSIIHYDLNTGNMLYDKESESLFPIDF 173 >5YK0-A nrPDB Length = 452 Score = 38.3 bits (88), Expect = 0.006, Method: Composition-based stats. Identities = 31/177 (17%), Positives = 58/177 (32%), Gaps = 56/177 (31%) Query: 23 AKVKFARNTDTGDNVAIKIMAKSTILKNR-MVDQIKREISIMKIV--------------- 66 +V A +D G VA+KI R + ++R + ++K + Sbjct: 146 GQVHKAIWSD-GREVAVKIQYPGADEALRADLKTMQRMVGVLKQLSPGADVQGVVDELVE 204 Query: 67 -----------------------RHP-----NIVRLYEVLASPSKIYIVLEFVTGGELFD 98 HP ++V + + ++ E++ G + + Sbjct: 205 RTEMELDYRLEAANQRAFAKAYHDHPRFQVPHVV-------ASAPKVVIQEWIEGVPMAE 257 Query: 99 RIVHKGRLEESESRKYFQQL-VDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFG 154 I H + +L DA G+ H D P N +L +G + + DFG Sbjct: 258 IIRHGTTEQRDLIGTLLAELTFDAPRRL---GLMHGDAHPGNFMLLPDGRMGIIDFG 311 >6G5I-z nrPDB Length = 568 Score = 37.9 bits (87), Expect = 0.010, Method: Composition-based stats. Identities = 35/167 (20%), Positives = 65/167 (38%), Gaps = 32/167 (19%) Query: 12 EVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH--- 68 E+ I G A V A +T G++ AIKI S ++ + E RH Sbjct: 181 EINGCISTGKEANVYHA-STANGESRAIKIYKTSILVFKDRDKYVSGEFR----FRHGYC 235 Query: 69 ----------------PNIVRLYEV-LASPSKIYI-----VLEFVTGGELFDRIVHKGRL 106 N++RL + P I + V+ F+ ++ ++ +L Sbjct: 236 KGNPRKMVKTWAEKEMRNLIRLNTAEIPCPEPIMLRSHVLVMSFIGKDDMPAPLLKNVQL 295 Query: 107 EESESRKYFQQLVDAVAHCHC-KGVYHRDLKPENLLLDTNGNLKVSD 152 ES++R+ + Q++ + + + H DL N+L G + + D Sbjct: 296 SESKARELYLQVIQYMRRMYQDARLVHADLSEFNMLY-HGGGVYIID 341 >4OTP-A nrPDB Length = 352 Score = 37.5 bits (86), Expect = 0.010, Method: Composition-based stats. Identities = 35/167 (20%), Positives = 65/167 (38%), Gaps = 32/167 (19%) Query: 12 EVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH--- 68 E+ I G A V A +T G++ AIKI S ++ + E RH Sbjct: 39 EINGCISTGKEANVYHA-STANGESRAIKIYKTSILVFKDRDKYVSGEFR----FRHGYC 93 Query: 69 ----------------PNIVRLYEV-LASPSKIYI-----VLEFVTGGELFDRIVHKGRL 106 N++RL + P I + V+ F+ ++ ++ +L Sbjct: 94 KGNPRKMVKTWAEKEMRNLIRLNTAEIPCPEPIMLRSHVLVMSFIGKDDMPAPLLKNVQL 153 Query: 107 EESESRKYFQQLVDAVAHCHC-KGVYHRDLKPENLLLDTNGNLKVSD 152 ES++R+ + Q++ + + + H DL N+L G + + D Sbjct: 154 SESKARELYLQVIQYMRRMYQDARLVHADLSEFNMLY-HGGGVYIID 199 >1L1L-A nrPDB Length = 739 Score = 34.5 bits (78), Expect = 0.11, Method: Composition-based stats. Identities = 27/134 (20%), Positives = 40/134 (29%), Gaps = 28/134 (20%) Query: 256 QGIKKDPW--------------FRLNYVPIRAREEEEVNLDDIRAVFDGIEGSYVA---- 297 + + W ++ IR E + D+ + I Y A Sbjct: 341 EKLMHHRWASNNSVAVDSAFSGYQPIAAGIRENGEPGIVNLDLSKNYGRIVDGYQAGIDG 400 Query: 298 ---------ENVERNDEGPLMMNAFEMITLSQGLNLSALFDRRQDFVKRQTRFVSRREPS 348 E N E + F +I QG +L +F + KR T E S Sbjct: 401 DVEGTNPCGEISLANGEPCNLFEVFPLIAEEQGWDLQEVFALAARYAKRVTFSPYDWEIS 460 Query: 349 -EIIANIEAVANSM 361 EII + SM Sbjct: 461 REIIQKNRRIGISM 474 >6G18-v nrPDB Length = 552 Score = 34.1 bits (77), Expect = 0.14, Method: Composition-based stats. Identities = 15/74 (20%), Positives = 33/74 (44%), Gaps = 6/74 (8%) Query: 80 SPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDLKPEN 139 ++ +V+E + G L +I H + + + ++ + G+ H D N Sbjct: 180 DYNRHAVVMELINGYPL-CQIHH-----VEDPASVYDEAMELIVKLANHGLIHGDFNEFN 233 Query: 140 LLLDTNGNLKVSDF 153 L+LD + ++ + DF Sbjct: 234 LILDESDHITMIDF 247 >6FDN-A nrPDB Length = 320 Score = 33.7 bits (76), Expect = 0.18, Method: Composition-based stats. Identities = 15/74 (20%), Positives = 33/74 (44%), Gaps = 6/74 (8%) Query: 80 SPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDLKPEN 139 ++ +V+E + G L +I H + + + ++ + G+ H D N Sbjct: 180 DYNRHAVVMELINGYPL-CQIHH-----VEDPASVYDEAMELIVKLANHGLIHGDFNEFN 233 Query: 140 LLLDTNGNLKVSDF 153 L+LD + ++ + DF Sbjct: 234 LILDESDHITMIDF 247 >6DFL-A nrPDB Length = 259 Score = 33.7 bits (76), Expect = 0.18, Method: Composition-based stats. Identities = 32/170 (18%), Positives = 58/170 (34%), Gaps = 22/170 (12%) Query: 18 GEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRL--- 74 G G F K+ G+ +AK+ + V ++E ++ + + + Sbjct: 45 GRGYFVKIHRG--IGWGE------IAKNLLTAKLPVLGARQEWQAIRRLHEAGVATMTAV 96 Query: 75 ----YEVLASPSKIYIVLE-FVTGGEL--FDRIVHKGRLEESESRKYFQQLVDAVAHCHC 127 + +IV E +L F + + R + + V H Sbjct: 97 AYGERGSDPARQHSFIVTEELAPTVDLEVFSQDWRERPPPPRLKRALVEAVARMVGDMHR 156 Query: 128 KGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTCGTP-NYV 176 GV HRD + LL T+ + DF LS + + +T TP + Sbjct: 157 AGVNHRDCYICHFLLHTDKPVSADDFRLSVI---DLHRAQTRDATPKRWR 203 >2AMX-A nrPDB Length = 376 Score = 31.8 bits (71), Expect = 0.59, Method: Composition-based stats. Identities = 17/101 (16%), Positives = 38/101 (37%) Query: 211 SETDLPGLYRKINAAEFSCPPWFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVP 270 S+ + ++R+I E C + +F + N + + I F Sbjct: 38 SKKERYEIWRRIPKVELHCHLDLTFSAEFFLKWARKYNLQPNMSDDEILDHYLFTKEGKS 97 Query: 271 IRAREEEEVNLDDIRAVFDGIEGSYVAENVERNDEGPLMMN 311 + + +++ D+ +D IE +E+ EG ++M Sbjct: 98 LAEFIRKAISVSDLYRDYDFIEDLAKWAVIEKYKEGVVLME 138 >4GYG-A nrPDB Length = 397 Score = 31.4 bits (70), Expect = 0.81, Method: Composition-based stats. Identities = 30/177 (16%), Positives = 54/177 (30%), Gaps = 48/177 (27%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKI-----MAKSTILKNRMVDQ---------- 55 Y VG IG G + + + V +KI ++ T+ NR + Sbjct: 97 YSVGSRIGVGKESDIMIVADEKGKQKV-LKIHRLGRISFRTVKANRDYLRNRSTGSWMYL 155 Query: 56 ----IKREISIMKIVRHPNIVRLYEVLASPSKIY-----IVLEFVTGGELFDRIVHKGRL 106 +E + MK + E P I IV+ L D + + Sbjct: 156 SRLAAIKEFAFMKAL-------YEEGFPVPEPIAQSRHTIVM------SLVDALPMRQVS 202 Query: 107 EESESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLK----------VSDF 153 + + L+ + G+ H D N+L+ + + + DF Sbjct: 203 SVPDPASLYADLIALILRLAKHGLIHGDFNEFNILIREEKDAEDPSSITLTPIIIDF 259 >6FAI-l nrPDB Length = 425 Score = 31.0 bits (69), Expect = 1.1, Method: Composition-based stats. Identities = 31/169 (18%), Positives = 57/169 (33%), Gaps = 35/169 (20%) Query: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKI-----------------MAKSTILKNRM- 52 Y VG TIG G + + + + V +KI + KS N M Sbjct: 95 YSVGNTIGVGKESDIYKVSDKNGNPRV-MKIHRLGRTSFHSVRNNRDYLKKSNQGANWMH 153 Query: 53 --VDQIKREISIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESE 110 +E M ++ ++ E + I +V+E + G + R+ + Sbjct: 154 LSRLAANKEYQFMSMLYSKGF-KVPEPFDNSRHI-VVMELIEGYPMR-RLRKHKNIP--- 207 Query: 111 SRKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDT------NGNLKVSDF 153 K + L+ + G+ H D N+++ + V DF Sbjct: 208 --KLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDF 254 >5MRF-Q nrPDB Length = 296 Score = 30.6 bits (68), Expect = 1.3, Method: Composition-based stats. Identities = 16/95 (16%), Positives = 42/95 (44%), Gaps = 5/95 (5%) Query: 312 AFEMITLSQGLNLSALFDRRQDFVKRQTRFVSRREPSEIIANIEAVANSMGFKSHTRNFK 371 +++ ++ + L +R ++F+ +F+ + P + ++++ V FKS +K Sbjct: 3 SYQHLSNVGSRVMKRLGNRPKNFLPHSEKFIKKSTPEFMKSDLKEVDEKTSFKSEKE-WK 61 Query: 372 T----RLEGLSSIKAGQLAVVIEIYEVAPSLFMVD 402 R+ +S G +AV+ + S + + Sbjct: 62 FIPGDRVVVMSGASKGNIAVIKSFDKRTNSFILDE 96 >6EF6-A nrPDB Length = 354 Score = 30.6 bits (68), Expect = 1.5, Method: Composition-based stats. Identities = 11/28 (39%), Positives = 17/28 (60%), Gaps = 3/28 (10%) Query: 129 GVYHRDLKPENLLLDTNG---NLKVSDF 153 G+ H DL+ NLL+D++ + V DF Sbjct: 226 GLIHADLRLANLLVDSSTPQRTITVIDF 253 >5G5P-A nrPDB Length = 805 Score = 30.6 bits (68), Expect = 1.5, Method: Composition-based stats. Identities = 19/124 (15%), Positives = 55/124 (44%), Gaps = 15/124 (12%) Query: 234 SAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLNYVPIRAREEEEVNLDDIRAVFDGIEG 293 S + + L +++ P+ ++ + +DPW + N + + EE ++DD+ +++ ++ Sbjct: 112 SHKARELPRFLINQEPQ--LEKRAFVQDPWDKANQEKMISLEE---SIDDLNELYETLKK 166 Query: 294 SYVAENV--------ERNDEGPLMMNAFEMITLSQGLNLSALFDRRQDFVKRQTRFVSRR 345 E ++ D + +A ++ L++ F+R + V+ + Sbjct: 167 MRNTERSIMEEKGLVDKADSAKDLYDA--IVFQGTCLDMCPTFERSRRNVEYTVYSYEKN 224 Query: 346 EPSE 349 +P++ Sbjct: 225 QPND 228 >4F11-A nrPDB Length = 433 Score = 30.6 bits (68), Expect = 1.5, Method: Composition-based stats. Identities = 10/47 (21%), Positives = 22/47 (46%) Query: 249 PKTRIQIQGIKKDPWFRLNYVPIRAREEEEVNLDDIRAVFDGIEGSY 295 P + I+ I+ + R ++ +R + E N ++A +D I+ Sbjct: 38 PAVELAIEQIRNESLLRPYFLDLRLYDTECDNAKGLKAFYDAIKYGP 84 >5IXC-A nrPDB Length = 814 Score = 30.6 bits (68), Expect = 1.6, Method: Composition-based stats. Identities = 14/61 (22%), Positives = 27/61 (44%), Gaps = 4/61 (6%) Query: 179 EVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFSCPPWFSAEVK 238 E+ + QG+ + D+W+ +L +L G + + L G + + P + S VK Sbjct: 417 ELRAEQGHPTTFVDLWAL--VLESMLHGQV--MDQKLSGQRAALERGQNPLPLYLSLNVK 472 Query: 239 F 239 Sbjct: 473 E 473 >4IFQ-A nrPDB Length = 970 Score = 29.8 bits (66), Expect = 2.4, Method: Composition-based stats. Identities = 20/88 (22%), Positives = 36/88 (40%), Gaps = 8/88 (9%) Query: 35 DNVAIK-IMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTG 93 + VA + I++ T N V R I++IV IV +++Y E + Sbjct: 87 EIVACELILSGDTTANNGKVQYFLRRQYILQIVS--FIVN---CFHEDTELY--QELIKN 139 Query: 94 GELFDRIVHKGRLEESESRKYFQQLVDA 121 G L I+ + ++ + QQ+ A Sbjct: 140 GALVSNILSAFKFIHTQLSEIKQQINKA 167 >2X8T-A nrPDB Length = 471 Score = 29.8 bits (66), Expect = 2.5, Method: Composition-based stats. Identities = 8/28 (28%), Positives = 15/28 (53%) Query: 67 RHPNIVRLYEVLASPSKIYIVLEFVTGG 94 +HPN+V + K+++V +GG Sbjct: 165 KHPNVVDPHTFFDKDGKLWMVYGSYSGG 192 >3LV4-A nrPDB Length = 456 Score = 29.1 bits (64), Expect = 3.7, Method: Composition-based stats. Identities = 9/43 (20%), Positives = 17/43 (39%) Query: 67 RHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEES 109 +HPN+V + K+++V +GG + K Sbjct: 142 KHPNVVDPHTFFDQNGKLWMVYGSYSGGIFILEMDKKTGFPLP 184 >3B6C-A nrPDB Length = 234 Score = 29.1 bits (64), Expect = 4.6, Method: Composition-based stats. Identities = 9/41 (21%), Positives = 20/41 (48%) Query: 96 LFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDLK 136 +FD ++ + + E E ++ +Q+ + + HRDL Sbjct: 57 VFDIVLTEVEVPEPEPGRWAEQVKEMCRSLRRMFLAHRDLA 97 >5L3X-B nrPDB Length = 405 Score = 28.7 bits (63), Expect = 4.8, Method: Composition-based stats. Identities = 13/49 (26%), Positives = 24/49 (48%), Gaps = 2/49 (4%) Query: 56 IKREISIMKIVRHPNIVRLY-EVLASPSKIYIVLEFVT-GGELFDRIVH 102 + EIS + HP +++L ++ + V+E + L DR+VH Sbjct: 269 LLDEISTCHQLLHPQVLQLLVKLFETEHSALDVMEQLELKKTLLDRMVH 317 >4ESA-B nrPDB Length = 146 Score = 28.7 bits (63), Expect = 5.6, Method: Composition-based stats. Identities = 11/50 (22%), Positives = 20/50 (40%), Gaps = 5/50 (10%) Query: 20 GTFAKVKFARNTDTGDNVA---IKIM--AKSTILKNRMVDQIKREISIMK 64 G+F + A VA IK++ + + +I E+SI+ Sbjct: 43 GSFGNLYNAEAIIGNQKVAAHGIKVLHGLDRAVKNMDNIKEIYAELSILH 92 >6GML-W nrPDB Length = 584 Score = 28.7 bits (63), Expect = 5.9, Method: Composition-based stats. Identities = 13/49 (26%), Positives = 24/49 (48%), Gaps = 2/49 (4%) Query: 56 IKREISIMKIVRHPNIVRLY-EVLASPSKIYIVLEFVT-GGELFDRIVH 102 + EIS + HP +++L ++ + V+E + L DR+VH Sbjct: 448 LLDEISTCHQLLHPQVLQLLVKLFETEHSQLDVMEQLELKKTLLDRMVH 496 >2ERX-A nrPDB Length = 172 Score = 28.3 bits (62), Expect = 6.7, Method: Composition-based stats. Identities = 19/104 (18%), Positives = 33/104 (31%), Gaps = 17/104 (16%) Query: 251 TRIQIQGIKKDPWFRLNYVPIRAREEE-EVNLDDIRAVFDGIEGSYVAENVERNDEGPLM 309 R+ I K + + + R EE + + I + +E + + DE P Sbjct: 68 QRLSIS--KGHAFILVYSITSRQSLEELKPIYEQICEIKGDVESIPIMLVGNKCDESPSR 125 Query: 310 --------------MNAFEMITLSQGLNLSALFDRRQDFVKRQT 339 AF + N+ LF + KR+T Sbjct: 126 EVQSSEAEALARTWKCAFMETSAKLNHNVKELFQELLNLEKRRT 169 >4FHA-A nrPDB Length = 311 Score = 28.3 bits (62), Expect = 7.3, Method: Composition-based stats. Identities = 6/26 (23%), Positives = 16/26 (61%) Query: 62 IMKIVRHPNIVRLYEVLASPSKIYIV 87 ++++ HPNI+ + E + + Y++ Sbjct: 155 MLRLADHPNIIGVKECTSLANMAYLI 180 >4A0G-A nrPDB Length = 831 Score = 27.9 bits (61), Expect = 8.4, Method: Composition-based stats. Identities = 11/70 (15%), Positives = 29/70 (41%), Gaps = 5/70 (7%) Query: 13 VGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIV 72 + +G+G ++V F+ N T +A+K+ + + + + + E I+ ++ Sbjct: 433 LLDGVGKGWASRVYFSDNGSTAIEIALKMAFRKFCVDHNFCEATEEEKHIVVK-----VI 487 Query: 73 RLYEVLASPS 82 L + Sbjct: 488 ALRGSYHGDT 497 >3F7W-A nrPDB Length = 288 Score = 27.9 bits (61), Expect = 8.5, Method: Composition-based stats. Identities = 12/52 (23%), Positives = 23/52 (44%), Gaps = 5/52 (9%) Query: 103 KGRLEESESRKYFQQLVDAVAHC----HCKGVYHRDLKPENLLLDTNGNLKV 150 +G L + R ++++DA+ H H DL N+L +G + + Sbjct: 160 RGALTPGDVR-LVEKVLDALDHLAGDPEPPARIHGDLWNGNVLWQDDGAVVI 210 >1OWC-A nrPDB Length = 427 Score = 27.9 bits (61), Expect = 9.3, Method: Composition-based stats. Identities = 9/48 (18%), Positives = 18/48 (37%), Gaps = 1/48 (2%) Query: 41 IMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYEVLASPSKIYIVL 88 I+ D+ K +++ ++ H I RL+ S V+ Sbjct: 89 ILLNGEKPTQEQYDEFKTTVTLHTMI-HEQITRLFHAFRRDSHPMAVM 135 >6INC-A nrPDB Length = 259 Score = 27.9 bits (61), Expect = 9.8, Method: Composition-based stats. Identities = 16/71 (22%), Positives = 22/71 (30%), Gaps = 13/71 (18%) Query: 70 NIVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKG 129 N+ +E + + GG L D + G L E K L A Sbjct: 193 NVAGYHEHFITDDR-------KGGGHLLDYQLDHGVLTFGEIHKLMIDLPADSAFLQAN- 244 Query: 130 VYHRDLKPENL 140 L P+NL Sbjct: 245 -----LHPDNL 250 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.313 0.153 0.454 Lambda K H 0.267 0.0466 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 18,557,631 Number of Sequences: 36641 Number of extensions: 813563 Number of successful extensions: 6423 Number of sequences better than 10.0: 534 Number of HSP's better than 10.0 without gapping: 939 Number of HSP's successfully gapped in prelim test: 81 Number of HSP's that attempted gapping in prelim test: 2286 Number of HSP's gapped (non-prelim): 1157 length of query: 446 length of database: 10,336,785 effective HSP length: 100 effective length of query: 346 effective length of database: 6,672,685 effective search space: 2308749010 effective search space used: 2308749010 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.2 bits) S2: 61 (27.9 bits)