BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q9K498 (461 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 3EL3-A nrPDB 931 0.0 3JUS-A nrPDB 149 3e-36 2VE3-A nrPDB 140 1e-33 3MDV-A nrPDB 135 3e-32 6C94-A nrPDB 134 6e-32 4KPA-A nrPDB 133 2e-31 6CR2-A nrPDB 125 5e-29 2W0A-A nrPDB 121 7e-28 4R20-A nrPDB 112 3e-25 3L4D-A nrPDB 110 1e-24 2WX2-A nrPDB 107 1e-23 5YLW-A nrPDB 102 2e-22 2X2N-A nrPDB 101 6e-22 6AYB-A nrPDB 99 6e-21 3S79-A nrPDB 94 1e-19 3K9V-A nrPDB 94 1e-19 6DA2-A nrPDB 92 4e-19 2HI4-A nrPDB 91 8e-19 2PG7-A nrPDB 91 1e-18 4WMZ-A nrPDB 91 1e-18 5FSA-A nrPDB 91 1e-18 3DL9-A nrPDB 87 1e-17 5VEU-A nrPDB 87 2e-17 5UYS-A nrPDB 82 4e-16 4H1N-A nrPDB 82 5e-16 3TBG-A nrPDB 82 6e-16 5E58-A nrPDB 79 3e-15 6B82-A nrPDB 79 3e-15 1WIY-A nrPDB 79 3e-15 3E6I-A nrPDB 79 6e-15 6DWN-A nrPDB 77 1e-14 3IBD-A nrPDB 77 1e-14 5VBU-A nrPDB 77 2e-14 1N6B-A nrPDB 76 3e-14 5JLC-A nrPDB 76 3e-14 3QZ1-A nrPDB 74 1e-13 5E0E-A nrPDB 72 6e-13 4R1Z-A nrPDB 72 6e-13 6IQ5-A nrPDB 72 7e-13 2NNH-A nrPDB 71 1e-12 5W0C-A nrPDB 68 7e-12 4GQS-A nrPDB 67 1e-11 3N9Z-A nrPDB 66 3e-11 4JBT-A nrPDB 65 6e-11 3WVS-A nrPDB 65 8e-11 5CJE-A nrPDB 64 1e-10 4WPZ-A nrPDB 64 1e-10 3SN5-A nrPDB 64 2e-10 6A7J-A nrPDB 64 2e-10 6A7I-A nrPDB 62 4e-10 1ODO-A nrPDB 61 9e-10 3MZS-A nrPDB 60 2e-09 1Z8P-A nrPDB 60 2e-09 4Z5P-A nrPDB 59 5e-09 4Z5Q-A nrPDB 59 5e-09 1CPT-A nrPDB 55 9e-08 3P3Z-A nrPDB 53 2e-07 3ABB-A nrPDB 53 2e-07 5OFQ-A nrPDB 53 3e-07 3EJB-B nrPDB 52 6e-07 1GWI-A nrPDB 51 1e-06 5LIE-A nrPDB 51 1e-06 5GWE-A nrPDB 50 2e-06 6DCD-A nrPDB 50 2e-06 5XJN-A nrPDB 50 2e-06 2VZM-A nrPDB 50 2e-06 2Y5N-A nrPDB 49 3e-06 4YZR-A nrPDB 49 7e-06 5D3U-A nrPDB 47 1e-05 6M7X-A nrPDB 47 1e-05 3R9C-A nrPDB 47 2e-05 5VWS-A nrPDB 47 2e-05 2WIO-A nrPDB 46 3e-05 6BLD-A nrPDB 46 3e-05 3BUJ-A nrPDB 46 3e-05 2RCM-A nrPDB 46 3e-05 5FYF-A nrPDB 45 5e-05 2Z36-A nrPDB 45 6e-05 5L94-A nrPDB 45 7e-05 4PWV-A nrPDB 45 7e-05 3MGX-A nrPDB 45 8e-05 3NC3-A nrPDB 45 1e-04 6GK6-A nrPDB 44 1e-04 5YHJ-A nrPDB 44 1e-04 2WIY-A nrPDB 44 1e-04 4MM0-A nrPDB 44 1e-04 2WM5-A nrPDB 44 2e-04 4TRI-A nrPDB 44 2e-04 5DE9-A nrPDB 43 3e-04 3IVY-A nrPDB 43 3e-04 4ZGX-A nrPDB 43 3e-04 3TKT-A nrPDB 43 3e-04 5IT1-A nrPDB 43 3e-04 6GMF-A nrPDB 43 4e-04 4UBS-A nrPDB 43 4e-04 2ZBZ-A nrPDB 43 4e-04 5FOI-A nrPDB 42 4e-04 5DQN-A nrPDB 42 5e-04 1EHE-A nrPDB 42 5e-04 3DBM-A nrPDB 42 5e-04 6FYJ-A nrPDB 42 6e-04 4GGV-A nrPDB 42 6e-04 3A1L-A nrPDB 42 6e-04 2IAG-A nrPDB 42 6e-04 2FR7-A nrPDB 41 9e-04 3RWL-A nrPDB 41 0.001 1UED-A nrPDB 41 0.001 5NWS-A nrPDB 41 0.001 4RM4-A nrPDB 41 0.001 3ABA-A nrPDB 41 0.001 5EX6-C nrPDB 40 0.001 4OQR-A nrPDB 40 0.002 3A50-A nrPDB 40 0.002 4XE3-A nrPDB 40 0.002 5Y1I-A nrPDB 40 0.002 4OQS-A nrPDB 39 0.004 6GII-A nrPDB 39 0.005 3B98-A nrPDB 39 0.006 3TYW-A nrPDB 38 0.008 3WEC-A nrPDB 38 0.009 6G5O-A nrPDB 38 0.009 5M0P-A nrPDB 37 0.014 2XKR-A nrPDB 37 0.025 3AWQ-A nrPDB 36 0.038 3OFT-A nrPDB 36 0.040 6G71-A nrPDB 35 0.048 2YJN-B nrPDB 35 0.059 4C9K-A nrPDB 35 0.063 6FH2-A nrPDB 34 0.12 5XW2-A nrPDB 34 0.14 2UUQ-A nrPDB 34 0.14 6B11-A nrPDB 34 0.14 4DO1-A nrPDB 33 0.20 6CVC-A nrPDB 33 0.22 3AHE-A nrPDB 33 0.30 2QBO-A nrPDB 32 0.48 6HQG-A nrPDB 32 0.65 1LG9-A nrPDB 32 0.74 5LIV-A nrPDB 31 0.90 6F88-A nrPDB 31 1.0 5M73-D nrPDB 30 2.4 2ZQJ-A nrPDB 29 3.7 5OMS-A nrPDB 29 3.7 6F0B-A nrPDB 29 5.2 6FRK-r nrPDB 29 5.5 5L9W-B nrPDB 28 6.5 5XWF-A nrPDB 28 6.7 1WZ2-A nrPDB 28 7.7 5Z9I-A nrPDB 28 8.3 1WKB-A nrPDB 28 9.5 >3EL3-A nrPDB Length = 467 Score = 931 bits (2406), Expect = 0.0, Method: Compositional matrix adjust. Identities = 461/461 (100%), Positives = 461/461 (100%) Query: 1 MTVESVNPETRAPAAPGAPELREPPVAGGGVPLLGHGWRLARDPLAFMSQLRDHGDVVRI 60 MTVESVNPETRAPAAPGAPELREPPVAGGGVPLLGHGWRLARDPLAFMSQLRDHGDVVRI Sbjct: 1 MTVESVNPETRAPAAPGAPELREPPVAGGGVPLLGHGWRLARDPLAFMSQLRDHGDVVRI 60 Query: 61 KLGPKTVYAVTNPELTGALALNPDYHIAGPLWESLEGLLGKEGVATANGPLHRRQRRTIQ 120 KLGPKTVYAVTNPELTGALALNPDYHIAGPLWESLEGLLGKEGVATANGPLHRRQRRTIQ Sbjct: 61 KLGPKTVYAVTNPELTGALALNPDYHIAGPLWESLEGLLGKEGVATANGPLHRRQRRTIQ 120 Query: 121 PAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDATSESFRVAVRVAARCLLRGQYMDERA 180 PAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDATSESFRVAVRVAARCLLRGQYMDERA Sbjct: 121 PAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDATSESFRVAVRVAARCLLRGQYMDERA 180 Query: 181 ERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQK 240 ERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQK Sbjct: 181 ERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQK 240 Query: 241 PDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRI 300 PDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRI Sbjct: 241 PDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRI 300 Query: 301 RDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESELGGYRIPAGA 360 RDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESELGGYRIPAGA Sbjct: 301 RDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESELGGYRIPAGA 360 Query: 361 DIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQL 420 DIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQL Sbjct: 361 DIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQL 420 Query: 421 TLITAALATKYRFEQVAGSNDAVRVGITLRPHDLLVRPVAR 461 TLITAALATKYRFEQVAGSNDAVRVGITLRPHDLLVRPVAR Sbjct: 421 TLITAALATKYRFEQVAGSNDAVRVGITLRPHDLLVRPVAR 461 >3JUS-A nrPDB Length = 461 Score = 149 bits (376), Expect = 3e-36, Method: Compositional matrix adjust. Identities = 105/424 (24%), Positives = 191/424 (45%), Gaps = 10/424 (2%) Query: 21 LREPPVAGGGVPLLGHGWRLARDPLAFMSQ-LRDHGDVVRIKLGPKTVYAVTNPELTGAL 79 ++ PP +P LGH + P+ F+ +G V + KT + + L Sbjct: 10 VKSPPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALL 69 Query: 80 --ALNPDYHIAGPLWESLEGLLGKEGVAT-ANGPLHRRQRRTIQPAFRLDAIPAYGPIME 136 + N D + A ++ L + +GVA P+ Q++ ++ + + I+E Sbjct: 70 FNSKNEDLN-AEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIE 128 Query: 137 EEAHALTERWQPGKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYR 196 +E E W + + + A+ CL + + E++ A + G Sbjct: 129 KETKEYFESWGESGEKNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGFSH 188 Query: 197 RMVVPLGPLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNG 256 + G LPLP+ RR + A ++ + + I +RR S +K DD+L LL+A +G Sbjct: 189 AAWLLPG---WLPLPSFRRRDRAHREIKDIFYKAIQKRRQSQEKIDDILQTLLDATYKDG 245 Query: 257 DPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGR--PVA 314 P+ + E+ ++ +L G T ++T W+ LA + E + V G P+ Sbjct: 246 RPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLT 305 Query: 315 FEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPK 374 ++ ++ L I E +RLRP + ++ R A + GY IP G + SP QR Sbjct: 306 YDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKD 365 Query: 375 SYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFE 434 S+ + L+F+PDR+L + A+ K+A PF AG+ +C ++F+ Q+ I + + Y F+ Sbjct: 366 SWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFD 425 Query: 435 QVAG 438 + G Sbjct: 426 LIDG 429 >2VE3-A nrPDB Length = 444 Score = 140 bits (353), Expect = 1e-33, Method: Compositional matrix adjust. Identities = 113/437 (25%), Positives = 187/437 (42%), Gaps = 20/437 (4%) Query: 25 PVAGGGVPLLGHGWRLARDPLAFMSQLRDHGDVVRIKLGPKTVYAVTNPELTGALALNPD 84 P G+P LG D + + G + + +L K V ++ L + Sbjct: 14 PPGDFGLPWLGETLNFLNDGDFGKKRQQQFGPIFKTRLFGKNVIFISG-ALANRFLFTKE 72 Query: 85 YHIAGPLWE-SLEGLLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALT 143 W S LLG +AT G +HR +R+ + AF + +Y P M+ Sbjct: 73 QETFQATWPLSTRILLGPNALATQMGEIHRSRRKILYQAFLPRTLDSYLPKMDGIVQGYL 132 Query: 144 ERWQPGKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLG 203 E+W V + R+ VAA L G+ + + + L T +G Sbjct: 133 EQWGKANEVIWYPQLRRMTFDVAA-TLFMGEKVSQNPQ-LFPWFETYIQG---------- 180 Query: 204 PLYRLPLPA-NRRFNDALADLHLLVDEIIAERRASGQKP---DDLLTALLEAKDDNGDPI 259 L+ LP+P N F + LL+ E+ +A Q+P +D L LL A+DDN P+ Sbjct: 181 -LFSLPIPLPNTLFGKSQRARALLLAELEKIIKARQQQPPSEEDALGILLAARDDNNQPL 239 Query: 260 GEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVR 319 E+ DQ++ +L G ET+ S + L H + +R+R E + + + E ++ Sbjct: 240 SLPELKDQILLLLFAGHETLTSALSSFCLLLGQHSDIRERVRQEQNKLQLSQELTAETLK 299 Query: 320 KLRHTGNVIVEAMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDN 379 K+ + V+ E +RL P V R + + + G+ P G + Y DP Y D Sbjct: 300 KMPYLDQVLQEVLRLIPPVGGGFRELIQDCQFQGFHFPKGWLVSYQISQTHADPDLYPDP 359 Query: 380 LEFDPDRWLPE-RAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAG 438 +FDP+R+ P+ A + P +A PF G R+C F+ ++ L L ++ + + G Sbjct: 360 EKFDPERFTPDGSATHNPPFAHVPFGGGLRECLGKEFARLEMKLFATRLIQQFDWTLLPG 419 Query: 439 SNDAVRVGITLRPHDLL 455 N + V + RP D L Sbjct: 420 QNLELVVTPSPRPKDNL 436 >3MDV-A nrPDB Length = 456 Score = 135 bits (341), Expect = 3e-32, Method: Compositional matrix adjust. Identities = 115/439 (26%), Positives = 196/439 (44%), Gaps = 36/439 (8%) Query: 37 GWRLARDPLAFMSQLRDHGDVVRIKLGPKTVYAVTNPELTGALALNPDYHIAGPLWESL- 95 G R+ +D F+ + +G VVR+ + KT VT+PE ++ Y+ ++ +L Sbjct: 8 GGRVLQD--VFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQ 65 Query: 96 ----EGLLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTE------- 144 E L G+ V+ N +QRR I AF ++ + E+A L E Sbjct: 66 TVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKAD 125 Query: 145 -----RWQPGKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMV 199 Q T A + A + LL Q +A +L + T R + + Sbjct: 126 GQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFL 185 Query: 200 VPLGPLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQK----PDDLLTALLEAKDDN 255 P R L R +++ L + + + RR + ++ P D+LT +L+A++ Sbjct: 186 ----PGKRKQL---REVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGA 238 Query: 256 GDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGG-RPVA 314 D G + D V G ET A+ + + + L+ PE R++ EV+ V G R + Sbjct: 239 QDDEG---LLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLD 295 Query: 315 FEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPK 374 FED+ +L++ V+ E++RL P W R E+ + G R+P +++S Y + R Sbjct: 296 FEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDT 355 Query: 375 SYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFE 434 ++D L F+PDR+ P A P++ PFS G R C F+ ++ ++ A L + F Sbjct: 356 YFEDPLTFNPDRFGP--GAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFR 413 Query: 435 QVAGSNDAVRVGITLRPHD 453 V G ++ TL+P D Sbjct: 414 LVPGQRFGLQEQATLKPLD 432 >6C94-A nrPDB Length = 497 Score = 134 bits (338), Expect = 6e-32, Method: Compositional matrix adjust. Identities = 101/370 (27%), Positives = 172/370 (46%), Gaps = 28/370 (7%) Query: 102 EGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQP----GKTVDATSE 157 +G+ +GP + R+ + P F D + Y I + + E+W+ GK+ D S+ Sbjct: 102 KGLLVLDGPKWFQHRKLLTPGFHYDVLKPYVAIFADSTRIMLEKWEKKACEGKSFDIFSD 161 Query: 158 SFRVAVRVAARCLL-RGQY-MDERAERLCVALATVFRGMYRRM---VVPLGPLYRLPLPA 212 +A+ +C +G ++ R VA++ + M +R+ +Y L P Sbjct: 162 VGHMALDTLMKCTFGKGDSGLNHRDSSYYVAVSELTLLMQQRIDSFQYHNDFIYWLT-PH 220 Query: 213 NRRFNDALADLHLLVDEIIAERRASGQKPD-----------DLLTALLEAKDDNGDPIGE 261 RRF A H D +I +R+A+ Q D L LL+ + ++G + + Sbjct: 221 GRRFLRACRAAHDHTDRVIRQRKAALQDEKEREKIQNRRHLDFLDILLDVRGESGVQLSD 280 Query: 262 QEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGR-PVAFEDVRK 320 ++ +V + G +T S I W L +A +PEH R R+EV + G + +ED+ K Sbjct: 281 TDLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQQRCREEVREILGDQDSFQWEDLAK 340 Query: 321 LRHTGNVIVEAMRLRPAVWVLTRR-AVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDN 379 + + + E RL P V + R+ + S + G +PAG+ I YA+ R+ + D Sbjct: 341 MTYLTMCMKECFRLYPPVPQVYRQLSKPVSFVDGRSLPAGSLISLHIYALHRNSDVWPDP 400 Query: 380 LEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGS 439 FDP R+ PE ++ YA PFSAG R C F+M ++ ++TA ++ F S Sbjct: 401 EVFDPLRFSPENSSGRHPYAFIPFSAGPRNCIGQQFAMNEMKVVTALCLLRFEF-----S 455 Query: 440 NDAVRVGITL 449 D +R+ I L Sbjct: 456 VDPLRLPIKL 465 >4KPA-A nrPDB Length = 494 Score = 133 bits (334), Expect = 2e-31, Method: Compositional matrix adjust. Identities = 88/360 (24%), Positives = 177/360 (49%), Gaps = 16/360 (4%) Query: 113 RRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQ---PGKTVDATSESFRVAVRVAARC 169 ++ + P+F A+ Y +M + A L ++W+ + ++ + R+ + C Sbjct: 121 KKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLC 180 Query: 170 LLRGQYMDERAERLCVALATVFRGMYRRM-----VVPLGPLYRLPLPANRRFNDALADLH 224 ++ ++ + ++ R + M P P Y R+F + + ++ Sbjct: 181 GFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYD---ENKRQFQEDIKVMN 237 Query: 225 LLVDEIIAERRASGQKPDDLLTALLEAKD-DNGDPIGEQEIHDQVVAILTPGSETIASTI 283 LVD+IIA+R+ASG++ DDLLT +L KD + G+P+ ++ I Q++ L G ET + + Sbjct: 238 DLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLL 297 Query: 284 MWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTR 343 + L L +P + +E V +++ V++L++ G V+ EA+RL P + Sbjct: 298 SFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSL 357 Query: 344 RAVAESELGG-YRIPAGADIIYSPYAIQRDPKSYDDNL-EFDPDRWLPERAANVPKYAMK 401 A ++ LGG Y + G +++ + RD + D++ EF P+R+ E + +P++A K Sbjct: 358 YAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERF--ENPSAIPQHAFK 415 Query: 402 PFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRVGITLRPHDLLVRPVAR 461 PF G+R C F++ + TL+ + + FE ++ +TL+P +V+ ++ Sbjct: 416 PFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSK 475 >6CR2-A nrPDB Length = 477 Score = 125 bits (313), Expect = 5e-29, Method: Compositional matrix adjust. Identities = 115/456 (25%), Positives = 190/456 (41%), Gaps = 53/456 (11%) Query: 22 REPPVAGGGVPLLGHGWRLARDPLAFMSQLR-DHGDVVR-IKLGPKT-VYAVTNPE---L 75 + PPV P +G DP F R +GD+ I LG KT VY T L Sbjct: 4 KTPPVVFHWFPFIGSTISYGIDPYKFFFDCRAKYGDIFTFILLGKKTTVYLGTKGNDFIL 63 Query: 76 TGALALNPDYHIAGPLWESLEGLLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIM 135 G L + PL + G+ V Q++ ++ DA+ +Y P++ Sbjct: 64 NGKLRDVCAEEVYSPL---TTPVFGRHVVYDCPNAKLMEQKKFVKYGLTSDALRSYVPLI 120 Query: 136 EEEAHALTER---WQPGKTV-DATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVF 191 +E + + +Q K V D + + A+R L + + + + F Sbjct: 121 TDEVESFVKNSPAFQGHKGVFDVCKTIAEITIYTASRSL--------QGKEVRSKFDSTF 172 Query: 192 RGMYRRMVVPLGPLYRL----PLPANRRFNDALADLHLLVDEIIAERRASGQKPD--DLL 245 +Y + + P+ + PLP NR+ + A L EII RR +G K D D++ Sbjct: 173 AELYHNLDMGFAPINFMLPWAPLPHNRKRDAAQRKLTETYMEIIKARRQAGSKKDSEDMV 232 Query: 246 TALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVE 305 L+ NG P+ ++EI ++A+L G + +ST W++ LA P+ + + E Sbjct: 233 WNLMSCVYKNGTPVPDEEIAHMMIALLMAGQHSSSSTASWIVLRLATRPDIMEELYQEQI 292 Query: 306 AVTGGR--PVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESELGG--YRIPAGAD 361 V G P+ +++++KL VI E +RL + + R + G Y IP + Sbjct: 293 RVLGSDLPPLTYDNLQKLDLHAKVIKETLRLHAPIHSIIRAVKNPMAVDGTSYVIPTSHN 352 Query: 362 IIYSPYAIQRDPKSYDDNLEFDPDRW-------------------LPERAANVPKYAMKP 402 ++ SP R + + + LE++P RW L + N P P Sbjct: 353 VLSSPGVTARSEEHFPNPLEWNPHRWDENIAASAEDDEKVDYGYGLVSKGTNSP---YLP 409 Query: 403 FSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAG 438 F AG+ +C + F+ QL ITA L +RF + G Sbjct: 410 FGAGRHRCIGEQFAYLQLGTITAVLVRLFRFRNLPG 445 >2W0A-A nrPDB Length = 455 Score = 121 bits (303), Expect = 7e-28, Method: Compositional matrix adjust. Identities = 112/422 (26%), Positives = 185/422 (43%), Gaps = 22/422 (5%) Query: 25 PVAGGGVPLLGHGWRLARDPLAFMSQLRDH-GDVVRIKLGPKTVYAVT----NPELTGAL 79 P GG GH DP+ M ++RD GDV +L K V ++ N A Sbjct: 7 PRVSGGHDEHGHLEEFRTDPIGLMQRVRDELGDVGTFQLAGKQVVLLSGSHANEFFFRAG 66 Query: 80 ALNPDYHIAGPLWESLEGLLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEA 139 + D A P + G E V P RR+ A R + + + +E++ Sbjct: 67 DDDLDQAKAYPFMTPIFG----EAVVFDASP-ERRKEMLHNAALRGEQMKGHAATIEDQV 121 Query: 140 HALTERWQPGKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMV 199 + W +D + + ++ CL+ ++ D+ R + RG Sbjct: 122 RRMIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERG-----T 176 Query: 200 VPLGPLY-RLPLPANRRFNDALADLHLLVDEIIAERRAS--GQKPD-DLLTALLEAKDDN 255 PL + LP+ + RR ++A L LV +I+ R A+ K D D+L L+ K + Sbjct: 177 DPLAYVDPYLPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAET 236 Query: 256 GDP-IGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTG-GRPV 313 G P EI ++++ G T + T W L L H + + DE++ + G GR V Sbjct: 237 GTPRFSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSV 296 Query: 314 AFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDP 373 +F +R++ NV+ E +RL P + +L R A E E+ G+RI G + SP R P Sbjct: 297 SFHALRQIPQLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIP 356 Query: 374 KSYDDNLEFDPDRW-LPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYR 432 + + D +F P R+ P + + ++ PF AG+ +C F++ Q+ I + L +Y Sbjct: 357 EDFPDPHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYE 416 Query: 433 FE 434 FE Sbjct: 417 FE 418 >4R20-A nrPDB Length = 486 Score = 112 bits (281), Expect = 3e-25, Method: Compositional matrix adjust. Identities = 105/427 (24%), Positives = 182/427 (42%), Gaps = 20/427 (4%) Query: 45 LAFMSQLRDHGDVVRIKLGPKTVYAVTNPELTGALALNPDYHIAGPLWESLEGLL--GKE 102 L F +G + + GP V+ L + L AG LL G + Sbjct: 43 LLFTQLSSQYGPLFGLYAGPHLTLVVSEIGLVREVLLQRGREFAGRPKMVTTDLLTQGGK 102 Query: 103 GVATAN-GPLHRRQRRTIQPAFRL--DAIPAYGPIMEEEAHALTERWQP--GKTVDATSE 157 +A A+ PL + RR + +F L + I++E A +L E Q G++ D + Sbjct: 103 DIAFADYSPLWKNHRRLVHSSFTLFGEGSNKLQTIVQEAADSLCEELQACRGQSSDLSVV 162 Query: 158 SFRVAVRVAARCLLRGQYMDERAERLCVALAT--VFRGMYRRMVVPLGPLYRL-PLPANR 214 R V R + Y E V + + + R +V + P R+ P + Sbjct: 163 LMRAVTNVICRLVFSSSYQPSDPELQTVIQYNDGIVQTIARGGLVDIFPWLRIFPNKDLK 222 Query: 215 RFNDALADLHLLVDEIIAERRASGQ--KPDDLLTALLEAK---DDNGDPIGEQEIHDQVV 269 R + ++ L+ + + E + S +P DLL ALL + D I E + Sbjct: 223 RLKECVSIRDQLLYKKLLEHKKSLTPGEPRDLLDALLIGQQRGSGGADDITEDHVLMTAA 282 Query: 270 AILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTG-GRPVAFEDVRKLRHTGNVI 328 G ET ++T++W + L HP+ +R++ E++ G RP D L V+ Sbjct: 283 EAFGAGVETTSTTLLWTIAFLLHHPQLQERVQAELDECVGVDRPPCLSDRPHLPLLDAVL 342 Query: 329 VEAMRLRPAVWVLT-RRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRW 387 E MR+RP +L A+ ++ LGG+ +P G ++ + +AI DPK +D +F+P+R+ Sbjct: 343 CEVMRIRPVSPILIPHVAMQDTSLGGHSVPKGTRVLVNMWAIHHDPKHWDQPEQFNPERF 402 Query: 388 LPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRF---EQVAGSNDAVR 444 L + + PF AG R C + + +L L + ++ F + + + R Sbjct: 403 LEPSGKKKTQSSFLPFGAGPRVCVGESLARIELFLFVSRPLQRFSFSCPSEASLPDLQGR 462 Query: 445 VGITLRP 451 G+ L+P Sbjct: 463 FGVVLQP 469 >3L4D-A nrPDB Length = 453 Score = 110 bits (275), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 103/431 (23%), Positives = 181/431 (41%), Gaps = 36/431 (8%) Query: 24 PPVAGGGVPLLGHGWRLARDPLAFMSQLRD-HGDVVRIKLGPKTVYAVTNPELTGALALN 82 PPV G P +GH + +DPL FM + + +G + + + + V + Sbjct: 5 PPVVHGTTPFVGHIIQFGKDPLGFMLKAKKKYGGIFTMNICGNRITVVGDVHQHSKF-FT 63 Query: 83 PDYHIAGP--LWESLEGLLGKEGVATAN-GPLHRRQRRTIQPAFRLDAIPAYGPIMEEEA 139 P I P ++ + + G EGVA A P R Q + + + P ++ E Sbjct: 64 PRNEILSPREVYSFMVPVFG-EGVAYAAPYPRMREQLNFLAEELTVAKFQNFAPSIQHEV 122 Query: 140 HALTE-RWQPGK-TVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRR 197 + W + ++ + + + A +CL G+ + +R + A F + + Sbjct: 123 RKFMKANWNKDEGEINILDDCSAMIINTACQCLF-GEDLRKRLD------ARQFAQLLAK 175 Query: 198 MVVPLGP-------LYRLPLPANRRFNDALADLHLLVDEIIAERRASGQKPD----DLLT 246 M L P + +LPLP + R DA A+L ++ EII R + D DLL Sbjct: 176 MESCLIPAAVFLPWILKLPLPQSYRCRDARAELQDILSEIIIAREKEEAQKDTNTSDLLA 235 Query: 247 ALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALAD--HPEHADRIRDEV 304 LL A +G + + E+ +VA + G T T W L L D + H ++ E+ Sbjct: 236 GLLGAVYRDGTRMSQHEVCGMIVAAMFAGQHTSTITTTWSLLHLMDPRNKRHLAKLHQEI 295 Query: 305 EAVTGGRPVAFEDV-RKLRHTGNVIVEAMRLRPAVWVLTRRAVAESELGGYRIPAGADII 363 + + +++V ++ E++R P + +L R+ + ++G Y +P G I Sbjct: 296 DEFPA--QLNYDNVMEEMPFAEQCARESIRRDPPLVMLMRKVLKPVQVGKYVVPEGDIIA 353 Query: 364 YSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLI 423 SP +D +++ + P W PER + A F AG KC + F + Q+ + Sbjct: 354 CSPLLSHQDEEAFPN-----PREWNPERNMKLVDGAFCGFGAGVHKCIGEKFGLLQVKTV 408 Query: 424 TAALATKYRFE 434 A + Y FE Sbjct: 409 LATVLRDYDFE 419 >2WX2-A nrPDB Length = 473 Score = 107 bits (267), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 113/434 (26%), Positives = 187/434 (43%), Gaps = 40/434 (9%) Query: 23 EPPVAGGGVPLLGHGWRLARDPLAFMSQL-RD-HGDVVRIKLGPKTVYAVTNPELTGALA 80 +PPV VP LGH + ++PL FM + RD V I +G + V V +P Sbjct: 17 DPPVYPVTVPFLGHIVQFGKNPLEFMQRCKRDLKSGVFTISIGGQRVTIVGDPHEHSRF- 75 Query: 81 LNPDYHIAGP--LWESLEGLLGKEGVATAN-GPLHRRQRRTIQPAFRLDAIPAYGPIMEE 137 +P I P ++ + + G EGVA A P R Q + + + P ++ Sbjct: 76 FSPRNEILSPREVYTIMTPVFG-EGVAYAAPYPRMREQLNFLAEELTIAKFQNFVPAIQH 134 Query: 138 EAHA-LTERWQPGK-TVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMY 195 E + E W+ + ++ + + + A +CL G+ + +R A F + Sbjct: 135 EVRKFMAENWKEDEGVINLLEDCGAMIINTACQCLF-GEDLRKRLN------ARHFAQLL 187 Query: 196 RRMVVPLGP-------LYRLPLPANRRFNDALADLHLLVDEIIAERRASGQKPD----DL 244 +M L P L RLPLP + R +A A+L ++ EII R D DL Sbjct: 188 SKMESSLIPAAVFMPWLLRLPLPQSARCREARAELQKILGEIIVAREKEEASKDNNTSDL 247 Query: 245 LTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHA---DRIR 301 L LL+A +G + E+ +VA + G T T W + L HP++ D++ Sbjct: 248 LGGLLKAVYRDGTRMSLHEVCGMIVAAMFAGQHTSTITTSWSMLHLM-HPKNKKWLDKLH 306 Query: 302 DEVEAVTGGRPVAFEDVR-KLRHTGNVIVEAMRLRPAVWVLTRRAVAESELGGYRIPAGA 360 E++ + +++V ++ + E++R P + ++ R AE ++G Y +P G Sbjct: 307 KEIDEFPAQ--LNYDNVMDEMPFAERCVRESIRRDPPLLMVMRMVKAEVKVGSYVVPKGD 364 Query: 361 DIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQL 420 I SP D +++ +P W PER V A F AG KC F++ Q+ Sbjct: 365 IIACSPLLSHHDEEAFP-----NPRLWDPERDEKVDG-AFIGFGAGVHKCIGQKFALLQV 418 Query: 421 TLITAALATKYRFE 434 I A +Y F+ Sbjct: 419 KTILATAFREYDFQ 432 >5YLW-A nrPDB Length = 495 Score = 102 bits (255), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 100/424 (23%), Positives = 182/424 (42%), Gaps = 25/424 (5%) Query: 32 PLLGHGWRLARDPLAFMSQL-RDHGDVVRIKLGPKTVYAVTNPELTGALALNPDYHIAGP 90 P++G+ +L +P ++L + +G ++ I LG V++PE+ + +G Sbjct: 36 PIVGNMLQLGANPHQVFAKLSKRYGPLMSIHLGSLYTVIVSSPEMAKEILHRHGQVFSGR 95 Query: 91 LWESLEGLLGKEGVATANGPLHR--RQRRTI--QPAFRLDAIPAYGPIMEEEAHALTERW 146 + ++ P+ R R I + F ++ A + ++ L + Sbjct: 96 TIAQAVHACDHDKISMGFLPVASEWRDMRKICKEQMFSNQSMEASQGLRRQKLQQLLDHV 155 Query: 147 Q----PGKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVP- 201 Q G+ VD +F + + + L Q E + + + G+ + VP Sbjct: 156 QKCSDSGRAVDIREAAFITTLNLMSATLFSSQ-ATEFDSKATMEFKEIIEGVATIVGVPN 214 Query: 202 ---LGPLYR--LPLPANRR----FNDALADLHLLVDEIIAERRASGQKP--DDLLTALLE 250 P+ R P RR F LA + ++E + +RA+ P DD L +++ Sbjct: 215 FADYFPILRPFDPQGVKRRADVFFGKLLAKIEGYLNERLESKRANPNAPKKDDFLEIVVD 274 Query: 251 AKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGG 310 N + ++ + GS+T ++I W + L +P+ R++ E+++V G Sbjct: 275 IIQANEFKLKTHHFTHLMLDLFVGGSDTNTTSIEWAMSELVMNPDKMARLKAELKSVAGD 334 Query: 311 RPVAFEDVR-KLRHTGNVIVEAMRLRP-AVWVLTRRAVAESELGGYRIPAGADIIYSPYA 368 + E KL + VI E MR+ P +L R+A ++ E+ GY IP G I+ + YA Sbjct: 335 EKIVDESAMPKLPYLQAVIKEVMRIHPPGPLLLPRKAESDQEVNGYLIPKGTQILINAYA 394 Query: 369 IQRDPKSYDDNLEFDPDRWLPERA-ANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAAL 427 I RDP + D FDP+R+L + Y + PF +G+R CP + L + TA L Sbjct: 395 IGRDPSIWTDPETFDPERFLDNKIDFKGQDYELLPFGSGRRVCPGMPLATRILHMATATL 454 Query: 428 ATKY 431 + Sbjct: 455 VHNF 458 >2X2N-A nrPDB Length = 475 Score = 101 bits (252), Expect = 6e-22, Method: Compositional matrix adjust. Identities = 108/429 (25%), Positives = 183/429 (42%), Gaps = 30/429 (6%) Query: 23 EPPVAGGGVPLLGHGWRLARDPLAFMSQLRDH--GDVVRIKLGPKTVYAVTNPELTGALA 80 +PPV VP+LGH + + PL FM + + + I + K V V +P Sbjct: 17 DPPVYPVTVPILGHIIQFGKSPLGFMQECKRQLKSGIFTINIVGKRVTIVGDPHEHSRFF 76 Query: 81 LNPDYHIAGP--LWESLEGLLGKEGVATAN-GPLHRRQRRTIQPAFRLDAIPAYGPIMEE 137 L P + P ++ + + G EGVA A P R Q + + + P ++ Sbjct: 77 L-PRNEVLSPREVYSFMVPVFG-EGVAYAAPYPRMREQLNFLAEELTIAKFQNFVPAIQH 134 Query: 138 EAHA-LTERWQPGK-TVDATSESFRVAVRVAARCLLRGQYMDER--AERLCVALATVFRG 193 E + W + ++ + + + A +CL G+ + +R A R LA + Sbjct: 135 EVRKFMAANWDKDEGEINLLEDCSTMIINTACQCLF-GEDLRKRLDARRFAQLLAKMESS 193 Query: 194 MYRRMVVPLGPLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQKPD----DLLTALL 249 + V L + R ++A +L ++ EII R+A+ D DLL+ LL Sbjct: 194 LIPAAVFLPILLKLPLP-QSARCHEARTELQKILSEIIIARKAAAVNKDSSTSDLLSGLL 252 Query: 250 EAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHP---EHADRIRDEVEA 306 A +G P+ E+ +VA + G T + T W + L HP +H + +R E+E Sbjct: 253 SAVYRDGTPMSLHEVCGMIVAAMFAGQHTSSITTTWSMLHLM-HPANVKHLEALRKEIEE 311 Query: 307 VTGGRPVAFEDVR-KLRHTGNVIVEAMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYS 365 + + +V ++ E++R P + +L R+ +A+ ++G Y +P G I S Sbjct: 312 FPAQ--LNYNNVMDEMPFAERCARESIRRDPPLLMLMRKVMADVKVGSYVVPKGDIIACS 369 Query: 366 PYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITA 425 P D +++ +P RW PER V + A F AG KC F + Q+ I A Sbjct: 370 PLLSHHDEEAFP-----EPRRWDPERDEKV-EGAFIGFGAGVHKCIGQKFGLLQVKTILA 423 Query: 426 ALATKYRFE 434 Y F+ Sbjct: 424 TAFRSYDFQ 432 >6AYB-A nrPDB Length = 466 Score = 98.6 bits (244), Expect = 6e-21, Method: Compositional matrix adjust. Identities = 98/445 (22%), Positives = 184/445 (41%), Gaps = 27/445 (6%) Query: 24 PPVAGGGVPLLGHGWRLARDPLAFM-SQLRDHGDVVRIKLGPKTVYAVTNPELTGALALN 82 PP +P +G A++P+ F+ + +GDV + K + + +P++ Sbjct: 12 PPRVPNLIPYVGSFVSFAKNPVQFIIDNSKKYGDVFTATILGKEMTFLNHPKILDTFFKA 71 Query: 83 PDYHIA-GPLWESLEGLLGKEGVATANGPLHR-RQRRTIQPAFRLDAIPAYGPIMEEEAH 140 D ++ ++ + + G V A+ Q + + + I E+E Sbjct: 72 TDNELSLRDVYRFMRPVFGTGVVYDADSTERMMEQVKFVSSGLTTARFRVFVDIFEDEIA 131 Query: 141 ALTERWQPGKTVDATSESFRVAVRVAARCLLRG---QYMDERAERLCVALATVFRGMYRR 197 + P TVD + + A+RCLL QY+ E+ L ++ + Sbjct: 132 HKVKELGPEGTVDVAELMADLIIFTASRCLLGDEVRQYLSEKN------LGKLYHDI-DD 184 Query: 198 MVVPLGPLY-RLPLPANRRFNDALADLHLLVDEIIAERRASGQK-PD--------DLLTA 247 + PL Y LP P + A+ ++ E++ +RR +K P+ D++ Sbjct: 185 GISPLSFFYPSLPAPKRDKARKAVGEI---FQELLDKRREEHKKHPERLLDESKMDVVDH 241 Query: 248 LLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAV 307 LL K +G + + ++A L G T + T W L + + + +++R E E + Sbjct: 242 LLTQKYKDGQELTDVHRIGILIAGLFAGQHTSSITSSWTLMNVISNKKVLEKVRKEQEEI 301 Query: 308 TGGRPVA-FEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSP 366 G V ++ V K+ + + EA+R+ P + ++ R A E Y IP G ++ SP Sbjct: 302 MGSDKVLDYDKVMKMDYLEACMKEALRMYPPLIMIMRMARKPRECEQYIIPKGNILVVSP 361 Query: 367 YAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAA 426 R +Y + FDP+R + KY PF AG+ KC ++F++ Q+ I + Sbjct: 362 SVAGRCTDTYTNPDVFDPERLTERKEHEKFKYGAVPFGAGRHKCIGENFALLQVKSIISI 421 Query: 427 LATKYRFEQVAGSNDAVRVGITLRP 451 L + E + D + + P Sbjct: 422 LLRYFDMEYIGKIPDPSYTSLVVGP 446 >3S79-A nrPDB Length = 503 Score = 94.0 bits (232), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 65/254 (25%), Positives = 126/254 (49%), Gaps = 23/254 (9%) Query: 214 RRFNDALADLHLLVDEIIAERR---ASGQKPD---DLLTALLEAKDDNGDPIGEQEIHDQ 267 +++ ++ DL ++ +IAE+R ++ +K + D T L+ A + GD + + ++ Sbjct: 242 KKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILA-EKRGD-LTRENVNQC 299 Query: 268 VVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNV 327 ++ +L +T++ ++ ++L +A HP + I E++ V G R + +D++KL+ N Sbjct: 300 ILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENF 359 Query: 328 IVEAMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDP--- 384 I E+MR +P V ++ R+A+ + + GY + G +II + + R LEF P Sbjct: 360 IYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHR--------LEFFPKPN 411 Query: 385 DRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVR 444 + L A NVP +PF G R C + +M + I L ++ + + G Sbjct: 412 EFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQC---- 467 Query: 445 VGITLRPHDLLVRP 458 V + HDL + P Sbjct: 468 VESIQKIHDLSLHP 481 >3K9V-A nrPDB Length = 482 Score = 94.0 bits (232), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 70/270 (25%), Positives = 124/270 (45%), Gaps = 21/270 (7%) Query: 188 ATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALADLHLLVDEIIAE----------RRAS 237 A F + M+ G + P+ ++R N + H L + I + +R S Sbjct: 203 ALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQRYS 262 Query: 238 GQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHA 297 Q D L + + D + ++E++ V + ET A+++MW+L L+ +P+ Sbjct: 263 QQPGADFLCDIYQQ-----DHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQ 317 Query: 298 DRIRDEVEAVT--GGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESELGGYR 355 R+ EV++V P A ED+R + + + E+MRL P+V TR + LG Y Sbjct: 318 RRLLQEVQSVLPDNQTPRA-EDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYA 376 Query: 356 IPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHF 415 +P G + + + +++D+ +F P+RWL ++ + +A PF GKR C Sbjct: 377 LPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWL-QKEKKINPFAHLPFGIGKRMCIGRRL 435 Query: 416 SMAQLTLITAALATKYRFEQVAGSNDAVRV 445 + QL L + KY + VA N+ V + Sbjct: 436 AELQLHLALCWIIQKY--DIVATDNEPVEM 463 >6DA2-A nrPDB Length = 487 Score = 92.0 bits (227), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 48/197 (24%), Positives = 100/197 (50%), Gaps = 5/197 (2%) Query: 243 DLLTALLEAKD----DNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHAD 298 D L ++++++ ++ + + E+ Q + + G ET +S + +++ LA HP+ Sbjct: 250 DFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQ 309 Query: 299 RIRDEVEAVTGGR-PVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESELGGYRIP 357 ++++E++AV + P ++ V ++ + V+ E +RL P L R + E+ G IP Sbjct: 310 KLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIP 369 Query: 358 AGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSM 417 G ++ YA+ RDPK + + +F P+R+ + N+ Y PF +G R C F++ Sbjct: 370 KGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFAL 429 Query: 418 AQLTLITAALATKYRFE 434 + L + + F+ Sbjct: 430 MNMKLALIRVLQNFSFK 446 >2HI4-A nrPDB Length = 495 Score = 91.3 bits (225), Expect = 8e-19, Method: Compositional matrix adjust. Identities = 112/452 (24%), Positives = 188/452 (41%), Gaps = 35/452 (7%) Query: 16 PGAPELREPPVAGGGVPLLGHGWRLARDP-LAFMSQLRDHGDVVRIKLGPKTVYAVTNPE 74 P P+ + P G PLLGH L ++P LA + +GDV++I++G V ++ + Sbjct: 9 PRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLD 68 Query: 75 -LTGALALNPDYHIAGP-LWESLEGLLGKE-GVATANGPLHRRQRRTIQPA---FRLDAI 128 + AL D P L+ S G+ +T +GP+ +RR Q A F + + Sbjct: 69 TIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASD 128 Query: 129 PAYGP--IMEE----EAHALTERWQ-----PGKTVDATSESFRVAVRVAARCLLRGQYMD 177 PA +EE EA AL R Q PG VA + A C GQ+ Sbjct: 129 PASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCF--GQHFP 186 Query: 178 ERAERLCVALATVFRGMYRRMV---VPLGPLYR-LPLPANRRFNDALADLHLLVDEIIAE 233 E ++ + + + + P+ R LP PA +RF + + + E Sbjct: 187 ESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQE 246 Query: 234 RRASGQKPD--DLLTALLEAKDD----NGDPIGEQEIHDQVVAILTPGSETIASTIMWLL 287 K D+ AL + +G+ I +++I + V I G +T+ + I W L Sbjct: 247 HYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSL 306 Query: 288 QALADHPEHADRIRDEVEAVTG-GRPVAFEDVRKLRHTGNVIVEAMRLRPAV-WVLTRRA 345 L PE +I+ E++ V G R D +L + I+E R + + + Sbjct: 307 MYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHST 366 Query: 346 VAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPK---YAMKP 402 ++ L G+ IP + + + + DP+ ++D EF P+R+L + K M Sbjct: 367 TRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMML 426 Query: 403 FSAGKRKCPSDHFSMAQLTLITAALATKYRFE 434 F GKR+C + + ++ L A L + F Sbjct: 427 FGMGKRRCIGEVLAKWEIFLFLAILLQQLEFS 458 >2PG7-A nrPDB Length = 476 Score = 90.9 bits (224), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 94/438 (21%), Positives = 185/438 (42%), Gaps = 34/438 (7%) Query: 31 VPLLGHGWRLARDPL--AFMSQLRDHGDVVRIKLGPKTVYAVTNPELTGALALNPDYHIA 88 +P +G+ +L + + + M +G V I LGP+ V + + ++ + Sbjct: 18 LPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFS 77 Query: 89 GPLWE-SLEGLLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYG--PIMEEEAHALTE- 144 G + + + + GV +NG ++ RR R + G ++EEA L + Sbjct: 78 GRGEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDA 137 Query: 145 -RWQPGKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLG 203 R G +D T R V + + ++ + ++ ++L + G+++ G Sbjct: 138 LRGTGGANIDPTFFLSRTVSNVISSIVFGDRF--DYKDKEFLSLLRMMLGIFQFTSTSTG 195 Query: 204 PLY--------RLPLPANRRFNDALADLHLLVDEIIAERRASGQK------PDDLL-TAL 248 LY LP P + F L +++ IA++ Q+ P D + + L Sbjct: 196 QLYEMFSSVMKHLPGPQQQAFQ-----LLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFL 250 Query: 249 LEAKDDNGDPIGEQEIHDQVVAIL---TPGSETIASTIMWLLQALADHPEHADRIRDEVE 305 + +++ +P E + + V+ L G+ET+++T+ + L HPE ++ +E++ Sbjct: 251 IRMQEEEKNPNTEFYLKNLVMTTLQLFVGGTETVSTTLRYGFLLLMKHPEVEAKVHEEID 310 Query: 306 AVTG-GRPVAFEDVRKLRHTGNVIVEAMRLRPAV-WVLTRRAVAESELGGYRIPAGADII 363 V G R FED K+ + VI E R + L RR +++ + +P G ++ Sbjct: 311 RVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVY 370 Query: 364 YSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLI 423 ++ RDP + + +F+P +L E+ A PFS GKR C + + +L L Sbjct: 371 PMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLF 430 Query: 424 TAALATKYRFEQVAGSND 441 + +R + D Sbjct: 431 FTTVMQNFRLKSSQSPKD 448 >4WMZ-A nrPDB Length = 539 Score = 90.5 bits (223), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 100/450 (22%), Positives = 188/450 (41%), Gaps = 64/450 (14%) Query: 24 PPVAGGGVPLLGHGWRLARDPLAFMSQL-RDHGD---------VVRIKLGPKTVYAVTNP 73 PP+ +P +G P F + + +GD V+ + LGPK V N Sbjct: 56 PPLVFYWIPWVGSAVVYGMKPYEFFEECQKKYGDIFSFVLLGRVMTVYLGPKGHEFVFNA 115 Query: 74 ELTGALALNPDYHIAGPLWESLEGLLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGP 133 +L A H+ P++ GK + Q++ ++ A +A +Y P Sbjct: 116 KLADVSAEAAYAHLTTPVF-------GKGVIYDCPNSRLMEQKKFVKGALTKEAFKSYVP 168 Query: 134 IMEEEAHA---------LTERWQPGKTVDATSESFRVAVRVAARCLLRGQYMDERAERLC 184 ++ EE + L ER T+D + + A+R LL + + Sbjct: 169 LIAEEVYKYFRDSKNFRLNER--TTGTIDVMVTQPEMTIFTASRSLL--------GKEMR 218 Query: 185 VALATVFRGMYRRM---VVPLGPLY-RLPLPANRRFNDALADLHLLVDEIIAERRASGQK 240 L T F +Y + P+ ++ LPL R+ + A + +I ERR + Sbjct: 219 AKLDTDFAYLYSDLDKGFTPINFVFPNLPLEHYRKRDHAQKAISGTYMSLIKERRKNNDI 278 Query: 241 PD-DLLTALLE-AKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHAD 298 D DL+ +L++ + +G + +QEI + ++ +L G T A+T W+L LA+ P+ Sbjct: 279 QDRDLIDSLMKNSTYKDGVKMTDQEIANLLIGVLMGGQHTSAATSAWILLHLAERPDVQQ 338 Query: 299 RIRDEVEAVT--GGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESEL--GGY 354 + +E V G + + ++ ++++ I E +R+ + L R+ + + + Y Sbjct: 339 ELYEEQMRVLDGGKKELTYDLLQEMPLLNQTIKETLRMHHPLHSLFRKVMKDMHVPNTSY 398 Query: 355 RIPAGADIIYSP-YAIQRDPKSYDDNLEFDPDRWLPERAANVP-----KYAMK------- 401 IPAG ++ SP Y RD + + + +F+ RW + A++ Y Sbjct: 399 VIPAGYHVLVSPGYTHLRD-EYFPNAHQFNIHRWNNDSASSYSVGEEVDYGFGAISKGVS 457 Query: 402 ----PFSAGKRKCPSDHFSMAQLTLITAAL 427 PF G+ +C +HF+ QL ++ + Sbjct: 458 SPYLPFGGGRHRCIGEHFAYCQLGVLMSIF 487 >5FSA-A nrPDB Length = 490 Score = 90.5 bits (223), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 98/456 (21%), Positives = 171/456 (37%), Gaps = 52/456 (11%) Query: 22 REPPVAGGGVPLLGHGWRLARDPLAFMSQLRDH----------GDVVRIKLGPKTVYAVT 71 + PP+ +P G + P F R G ++ + LGPK V Sbjct: 4 KTPPLVFYWIPWFGSAASYGQQPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGHEFVF 63 Query: 72 NPELTGALALNPDYHIAGPLWESLEGLLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAY 131 N +L+ A H+ P+ G + Q++ + A D+ Y Sbjct: 64 NAKLSDVSAEEAYKHLTTPV-------FGTGVIYDCPNSRLMEQKKFAKFALTTDSFKRY 116 Query: 132 GPIMEEEA---HALTERWQPGKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALA 188 P + EE E ++ + + + + R + DE + A Sbjct: 117 VPKIREEILNYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFA 176 Query: 189 TVFRGMYRRMVVPLGPLY-RLPLPANRRFNDALADLHLLVDEIIAERRASGQ-KPD-DLL 245 ++ + + P+ ++ LPLP R + A + + I RR G P+ DL+ Sbjct: 177 QLYSDL-DKGFTPINFVFPNLPLPHYWRRDAAQKKISATYMKEIKLRRERGDIDPNRDLI 235 Query: 246 TALL-EAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEV 304 +LL + +G + +QEI + ++ IL G T AST W L L + P D I EV Sbjct: 236 DSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEV 295 Query: 305 EAV---TGG--RPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESEL--GGYRIP 357 + GG + +ED++KL N I E +R+ + + R+ + Y +P Sbjct: 296 VELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVP 355 Query: 358 AGADIIYSPYAIQRDPKSYDDNLEFDPDRW---------LPERAANVPKYAMK------- 401 G ++ SP + +D+ +FDP RW + +++ Y Sbjct: 356 KGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVS 415 Query: 402 ----PFSAGKRKCPSDHFSMAQLTLITAALATKYRF 433 PF G+ +C + F+ QL I R+ Sbjct: 416 SPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRW 451 >3DL9-A nrPDB Length = 479 Score = 87.0 bits (214), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 60/238 (25%), Positives = 116/238 (48%), Gaps = 13/238 (5%) Query: 231 IAERRASGQKP-------DDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTI 283 + E+ + +KP D L + + K+D ++ + V ++ G+ET + + Sbjct: 234 LIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVL 293 Query: 284 MWLLQALADHPEHADRIRDEVEAVTG--GRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVL 341 W + +A +P +++ E++ + G G+P +++D K+ +T V+ E +R V + Sbjct: 294 RWAILFMALYPNIQGQVQKEIDLIMGPNGKP-SWDDKCKMPYTEAVLHEVLRFCNIVPLG 352 Query: 342 TRRAVAE-SELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAM 400 A +E + + GY IP G +I + Y++ D K + D F P+R+L K A+ Sbjct: 353 IFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEAL 412 Query: 401 KPFSAGKRKCPSDHFSMAQLTLITAALATKY--RFEQVAGSNDAVRVGITLRPHDLLV 456 PFS G+R C +H + ++ L AL ++ F + R+G+TL+P L+ Sbjct: 413 VPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGMTLQPQPYLI 470 >5VEU-A nrPDB Length = 480 Score = 87.0 bits (214), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 92/443 (20%), Positives = 181/443 (40%), Gaps = 60/443 (13%) Query: 31 VPLLGHGWRLARDPLAFMSQL-RDHGDVVRIKLGPKTVYAVTNPELTGALALNPDYHI-- 87 +PLLG+ + F ++ + +G + G V A+T+P++ + + Y + Sbjct: 23 LPLLGNVLSYRQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFT 82 Query: 88 ----AGPLWESLEGLLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALT 143 GP+ G + K ++ A +R R + P F + PI+ + L Sbjct: 83 NRRSLGPV-----GFM-KSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLV 136 Query: 144 -------ERWQPGKTVDA---------TSESFRVAVRV----------AARCLLRGQYMD 177 E+ +P D T SF V + + + L+ ++D Sbjct: 137 RNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLD 196 Query: 178 ERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALADLHLLVDEIIAERRAS 237 L + L ++ + V L P D + L V+ + R Sbjct: 197 PLF--LSIILFPFLTPVFEALNVSLFP------------KDTINFLSKSVNRMKKSRLND 242 Query: 238 GQKPD-DLLTALLEAKD----DNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALAD 292 QK D L ++++++ ++ + + E+ Q + + G ET +S + + L LA Sbjct: 243 KQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELAT 302 Query: 293 HPEHADRIRDEVEAVTGGR-PVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESEL 351 HP+ +++ E++AV + P ++ V ++ + V+ E +RL P L R + E+ Sbjct: 303 HPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEI 362 Query: 352 GGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCP 411 G IP G+ ++ YA+ DPK + + EF P+R+ ++ ++ Y PF G R C Sbjct: 363 NGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERF-SKKKDSIDPYIYTPFGTGPRNCI 421 Query: 412 SDHFSMAQLTLITAALATKYRFE 434 F++ + L + + F+ Sbjct: 422 GMRFALMNMKLALIRVLQNFSFK 444 >5UYS-A nrPDB Length = 494 Score = 82.0 bits (201), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 89/419 (21%), Positives = 173/419 (41%), Gaps = 36/419 (8%) Query: 47 FMSQLRDHGDVVRIKLGPKTVYAVTNPELTGALALNPDYHIAG-PLWESLE-GLLGKEGV 104 F + +G + +++G KT V + +L + + +G P +L+ ++G+ Sbjct: 35 FFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGI 94 Query: 105 ATANGPLH-RRQRRTIQPAFRL--DAIPAYGPIMEEEAHALTERW--QPGKTVDATSESF 159 A A+ H + RR F L D I+ +E L + G+++D + F Sbjct: 95 AFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVF 154 Query: 160 RVAVRVAARCLLRGQYMDERAERLCVALAT--VFRGMYRRMVVPLGPLYRL-PLPANRRF 216 V + Y + E + + + + +V L P ++ P + Sbjct: 155 VAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKL 214 Query: 217 NDALADLHLLVDEIIAERRASGQKPD--DLLTALLEAK--DDNGDP--------IGEQEI 264 + + L+++I+ + + ++L L++AK DNG+ + + I Sbjct: 215 KSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHI 274 Query: 265 HDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTG-GRPVAFEDVRKLRH 323 + I G ET S + W L L +P+ ++ +E++ G R D +L Sbjct: 275 LTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLL 334 Query: 324 TGNVIVEAMRLRP-AVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEF 382 I E +RLRP A ++ +A +S +G + + G ++I + +A+ + K + Sbjct: 335 LEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQ---- 390 Query: 383 DPDRWLPERAAN-------VPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFE 434 PD+++PER N P + PF AG R C + + +L LI A L ++ E Sbjct: 391 -PDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLE 448 >4H1N-A nrPDB Length = 479 Score = 82.0 bits (201), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 97/428 (22%), Positives = 173/428 (40%), Gaps = 34/428 (7%) Query: 31 VPLLGHGWRLARDPL--AFMSQLRDHGDVVRIKLGPKTVYAVTNPE-LTGALALNPDYHI 87 +P+LG+ ++ R L +F+ +GDV + LG + V + + + AL + Sbjct: 18 LPVLGNLLQMDRKGLLRSFLRLREKYGDVFTVYLGSRPVVVLCGTDAIREALVDQAEAFS 77 Query: 88 AGPLWESLEGLLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYG-------PIMEEEAH 140 ++ + GV ANG R RR F L + +G ++EEA Sbjct: 78 GRGKIAVVDPIFQGYGVIFANGERWRALRR-----FSLATMRDFGMGKRSVEERIQEEAR 132 Query: 141 ALTE--RWQPGKTVDATSESFRVAVRVAARCLL--RGQYMDERAERLC--VALATVFRGM 194 L E R G +D T + + + R Y D RL + Sbjct: 133 CLVEELRKSKGALLDNTLLFHSITSNIICSIVFGKRFDYKDPVFLRLLDLFFQSFSLISS 192 Query: 195 YRRMVVPLGPLYRLPLPA-NRRFNDALADLHLLVDEIIAERRAS--GQKPDDLL-TALLE 250 + V L + P +R+ L +++ + + + + RA+ P D + LL Sbjct: 193 FSSQVFELFSGFLKYFPGTHRQIYRNLQEINTFIGQSVEKHRATLDPSNPRDFIDVYLLR 252 Query: 251 AKDDNGDPIGEQEIHDQ-----VVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVE 305 + D DP E H Q V+++ G+ET ++T+ + + +P +R++ E+E Sbjct: 253 MEKDKSDP--SSEFHHQNLILTVLSLFAAGTETTSTTLRYGFLLMLKYPHVTERVQKEIE 310 Query: 306 AVTGG-RPVAFEDVRKLRHTGNVIVEAMRLRPAV-WVLTRRAVAESELGGYRIPAGADII 363 V G RP A +D K+ +T VI E RL + + + +++ GY IP ++ Sbjct: 311 QVIGSHRPPALDDRAKMPYTDAVIHEIQRLGDLIPFGVPHTVTKDTQFRGYVIPKNTEVF 370 Query: 364 YSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLI 423 + DP+ ++ F+P +L A PFS GKR C + + +L L Sbjct: 371 PVLSSALHDPRYFETPNTFNPGHFLDANGALKRNEGFMPFSLGKRICLGEGIARTELFLF 430 Query: 424 TAALATKY 431 + + Sbjct: 431 FTTILQNF 438 >3TBG-A nrPDB Length = 479 Score = 82.0 bits (201), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 74/285 (25%), Positives = 124/285 (43%), Gaps = 17/285 (5%) Query: 169 CLLRGQYMDERAERLCVALATVFR---GMYRRMVVPLGPLYRLPLPANR--RFNDALADL 223 C R +Y D R RL + G R ++ + L +P A + RF A Sbjct: 169 CGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQ 228 Query: 224 HLLVDEIIAERRAS---GQKPDDLLTALL-EAKDDNGDP---IGEQEIHDQVVAILTPGS 276 +DE++ E R + Q P DL A L E + G+P ++ + V + + G Sbjct: 229 ---LDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGM 285 Query: 277 ETIASTIMWLLQALADHPEHADRIRDEVEAVTGG-RPVAFEDVRKLRHTGNVIVEAMRLR 335 T ++T+ W L + HP+ R++ E++ V G R D + +T VI E R Sbjct: 286 VTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFG 345 Query: 336 PAVWV-LTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAAN 394 V + +T + E+ G+RIP G +I + ++ +D ++ F P+ +L + Sbjct: 346 DIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHF 405 Query: 395 VPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGS 439 V A PFSAG+R C + + +L L +L + F G Sbjct: 406 VKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQ 450 >5E58-A nrPDB Length = 493 Score = 79.3 bits (194), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 92/409 (22%), Positives = 163/409 (39%), Gaps = 28/409 (6%) Query: 46 AFMSQLRDHGDVVRIKLGPKTVYAVTNPE-LTGALALNPDYHIAGPLWESLEGLLGKEGV 104 +FM +GDV + LGP+ V + E + AL + ++ ++G G+ Sbjct: 54 SFMRIREKYGDVFTVHLGPRPVVMLYGTEAIREALVDQAEAFSGRGTIAVIKPVIGDYGM 113 Query: 105 ATANGPLHRRQRRTIQPAFRLDAIPAYG-------PIMEEEAHALTERWQP--GKTVDAT 155 +NG + RR F L + +G ++EEA L E Q G +D T Sbjct: 114 IFSNGERWKVLRR-----FSLATMRDFGMGKRSVEDRIQEEAQCLVEELQKSQGAPLDPT 168 Query: 156 SESFRVAVRVAARCLL--RGQYMDERAERLCVALATVFRGM--YRRMVVPLGPLYRLPLP 211 + + + R Y D + RL F M + V L + P Sbjct: 169 FLFQCITANIICSIVFGERYDYKDRQFLRLLDLFYRTFSLMSSFSSQVFELFSGFMKYFP 228 Query: 212 -ANRRFNDALADLHLLVDEIIAERRAS--GQKPDDLLTALL----EAKDDNGDPIGEQEI 264 A+R+ L ++ V + + + RA+ P D + L + K + Q + Sbjct: 229 GAHRQITRNLQEILDYVGQSVEKHRATLDPSNPRDFIDTYLLRMEKEKSNQHTEFHHQNL 288 Query: 265 HDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGG-RPVAFEDVRKLRH 323 V+++ G+ET ++T+ + + +P A++++ E++ V G R ED K+ + Sbjct: 289 LISVLSLFFAGTETTSTTLRYGFLLMLKYPHVAEKVQKEIDQVIGSHRLPTLEDRTKMPY 348 Query: 324 TGNVIVEAMRLRPAVWVLTRRAVAESELG-GYRIPAGADIIYSPYAIQRDPKSYDDNLEF 382 T VI E R + V + L GY +P ++ + DP+ ++ F Sbjct: 349 TDAVIHEIQRFSDLAPIGAPHKVTKDTLFRGYLLPKNTEVYPILSSALHDPQYFEQPGTF 408 Query: 383 DPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKY 431 +PD +L A A PFS GKR C + + +L L + + Sbjct: 409 NPDHFLDANGALKKSEAFMPFSIGKRICLGEGIARNELFLFFTTILQNF 457 >6B82-A nrPDB Length = 509 Score = 79.3 bits (194), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 105/465 (22%), Positives = 185/465 (39%), Gaps = 31/465 (6%) Query: 22 REPPVAGGGVPLLGHGWRLARD--PLAFMSQL-RDHGDVVRIKLGPKTVYAVTNPELTGA 78 R PP + +P++G L D P F L + +GD+ + +G + V N Sbjct: 23 RSPP-SLPSLPIIGSLMSLVSDSPPHIFFQDLQKKYGDLYSLMMGSHKLLIVNNHHHAKE 81 Query: 79 LALNPDYHIAGPLWESLEGLLGKEG--VATAN-GPLHRRQRRTIQPAFRL--DAIPAYGP 133 + + AG LL ++G +A A+ + R+ + A + + + Sbjct: 82 ILIKKGKIFAGRPRTVTTDLLTRDGKDIAFADYSSTWKFHRKMVHGALCMFGEGSVSIEK 141 Query: 134 IMEEEAHALTERWQPGKT--VDATSESFRVAVRVAARCLLRGQYM--DERAERLCVALAT 189 I+ EA ++ E + VD E R V Y D E + Sbjct: 142 IICREASSMCEVLTESQNSAVDLGPELTRAVTNVVCALCFNSSYKRGDAEFESMLQYSQG 201 Query: 190 VFRGMYRRMVVPLGP-LYRLPLPANRRFNDALADLHLLVDEIIAERRA--SGQKPDDLLT 246 + + + +V + P L P R ++ L+ + E + S DLL Sbjct: 202 IVDTVAKDSLVDIFPWLQIFPNKDLRILRQCISIRDKLLQKKYEEHKVTYSDNVQRDLLD 261 Query: 247 ALLEAK---DDNGDP-----IGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHAD 298 ALL AK ++N + E + V I G ET +T+ W + L +P+ Sbjct: 262 ALLRAKRSSENNNSSTRDVGLTEDHVLMTVGEIFGAGVETTTTTLKWSIAYLVHNPQVQR 321 Query: 299 RIRDEVEAVTGG-RPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLT-RRAVAESELGGYRI 356 +I++E+++ G R D L + I E MR+RP +L A+ +S +G Y + Sbjct: 322 KIQEELDSKIGKERHPQLSDRGNLPYLEATICEVMRIRPVSPLLIPHVALQDSSVGEYTV 381 Query: 357 PAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANV--PKYAMKPFSAGKRKCPSDH 414 G ++ + +++ D K + + FDP R+L E + P + PF AG R C + Sbjct: 382 QKGTRVVINMWSLHHDEKEWKNPELFDPGRFLNEEGDGLCCPSGSYLPFGAGVRVCLGEA 441 Query: 415 FSMAQLTLITAALATKYRFEQVAGS---NDAVRVGITLRPHDLLV 456 + +L L A + ++ E G + + G+ L+P V Sbjct: 442 LAKMELFLFLAWILQRFTLEMPTGQPLPDLQGKFGVVLQPKKFKV 486 >1WIY-A nrPDB Length = 389 Score = 79.3 bits (194), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 100/413 (24%), Positives = 159/413 (38%), Gaps = 52/413 (12%) Query: 40 LARDPLAFMSQLRDHGDVVRIKLGPKTVYAVTNPELTGALALNPDYHIAGPLWESLEGLL 99 L +DPLA + + + + L + + +PE L A + +L L Sbjct: 16 LQQDPLAVLLEWGRAHPRLFLPLPRFPLALIFDPEGVEGALLAEGTTKATFQYRALSRLT 75 Query: 100 GKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDATSESF 159 G+ G+ T G + R+ ++ F ++ Y MEEEA A W+ G+ D E Sbjct: 76 GR-GLLTDWGKSWKEARKALKDPFLPKSVRGYREAMEEEAWAFFGEWR-GEERDLDHEML 133 Query: 160 RVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDA 219 +++R+ R L AE AL + M PL L L A RF Sbjct: 134 ALSLRLLGRALFGKPLSPSLAEHALKALDRI-------MAQTRSPLALLDLAAEARFRKD 186 Query: 220 LADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETI 279 L+ + +I S + + + V +L G ET+ Sbjct: 187 RGALYREAEALIVHPPLSH--------------------LPRERALSEAVTLLVAGHETV 226 Query: 280 ASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVW 339 AS + W L+ P+ R+ + EA EA+RL P W Sbjct: 227 ASALTWSFLLLSHRPDWQKRVAESEEAAL-----------------AAFQEALRLYPPAW 269 Query: 340 VLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYA 399 +LTRR LG R+P G ++ SPY QR + + F P+R+L ER +Y Sbjct: 270 ILTRRLERPLLLGEDRLPQGTTLVLSPYVTQR--LYFPEGEAFQPERFLAERGTPSGRYF 327 Query: 400 MKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRVGITLRPH 452 PF G+R C F++ + ++ A ++R + + V +TLRP Sbjct: 328 --PFGLGQRLCLGRDFALLEGPIVLRAFFRRFRLDPLPFPR--VLAQVTLRPE 376 >3E6I-A nrPDB Length = 476 Score = 78.6 bits (192), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 92/365 (25%), Positives = 153/365 (41%), Gaps = 35/365 (9%) Query: 103 GVATANGPLHRRQRRTIQPAFRLDAIPAYG-------PIMEEEAHALTE--RWQPGKTVD 153 G+ NGP + RR F L + YG ++ EAH L E R G+ D Sbjct: 92 GIIFNNGPTWKDIRR-----FSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFD 146 Query: 154 ATSESFRVAVRVAARCLLRGQ--YMDERAERLCVALATVFRGMYRRMVVPLGPLYR-LP- 209 T V A L R Y DE+ RL +F + + P LY P Sbjct: 147 PTFLIGCAPCNVIADILFRKHFDYNDEKFLRL----MYLFNENFHLLSTPWLQLYNNFPS 202 Query: 210 ----LP-ANRRFNDALADLHLLVDEIIAERRAS--GQKPDDLLTALL---EAKDDNGDPI 259 LP ++R+ +A++ V E + E S P DL LL E + + + + Sbjct: 203 FLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERL 262 Query: 260 GEQE-IHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTG-GRPVAFED 317 + I V + G+ET ++T+ + L L +PE +++ +E++ V G R A +D Sbjct: 263 YTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKD 322 Query: 318 VRKLRHTGNVIVEAMRLRPAV-WVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSY 376 +++ + V+ E R V L A ++ GY IP G ++ + ++ D + + Sbjct: 323 RQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEF 382 Query: 377 DDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQV 436 D +F P+ +L E KPFS GKR C + + +L L+ A+ + + + Sbjct: 383 PDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPL 442 Query: 437 AGSND 441 D Sbjct: 443 VDPKD 447 >6DWN-A nrPDB Length = 491 Score = 77.4 bits (189), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 108/450 (24%), Positives = 187/450 (41%), Gaps = 43/450 (9%) Query: 21 LREPPVAGGGVPLLGHGWRLARDP-LAFMSQLRDHGDVVRIKLGPKTVYAVTNPE-LTGA 78 L+ PP G PL+GH L ++P LA + +GDV++I++G V ++ + + A Sbjct: 10 LKNPP-GPWGWPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQA 68 Query: 79 LALNPDYHIAGPLWESLEGLLGKEGVATA--NGPLHRRQRRTIQ---PAFRLDAIPAYGP 133 L D P + + + ++ + +GP+ +RR Q +F + + PA Sbjct: 69 LVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASST 128 Query: 134 --IMEE----EAHALTERWQ-----PGKTVDATSESFRVAVRVAARCLLRGQYMDERAER 182 +EE EA L Q PG V + A C R +Y E Sbjct: 129 SCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGR-RYDHNHQEL 187 Query: 183 LCVALATVFRGMYRRMVVPLG------PLYR-LPLPANRRFNDALADLHLLVDEIIAERR 235 L + G VV G P+ R LP P+ F D + + +++ E Sbjct: 188 LSLVNLNNNFGE----VVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHY 243 Query: 236 ASGQK------PDDLLTALLEAK-DDNGD-PIGEQEIHDQVVAILTPGSETIASTIMWLL 287 + +K D L+ E + D+N + + +++I + V+ + G +T+ + I W L Sbjct: 244 KTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSL 303 Query: 288 QALADHPEHADRIRDEVEAVTG-GRPVAFEDVRKLRHTGNVIVEAMRLRPAV-WVLTRRA 345 L +P +I++E++ V G R D L + I+E R V + + Sbjct: 304 MYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHST 363 Query: 346 VAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAA--NVPKYAMKPF 403 ++ L G+ IP G + + + I D K + + EF P+R+L A V + F Sbjct: 364 TRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIF 423 Query: 404 SAGKRKCPSDHFSMAQLTLITAALATKYRF 433 GKRKC + + ++ L A L + F Sbjct: 424 GMGKRKCIGETIARWEVFLFLAILLQRVEF 453 >3IBD-A nrPDB Length = 476 Score = 77.4 bits (189), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 92/413 (22%), Positives = 159/413 (38%), Gaps = 36/413 (8%) Query: 46 AFMSQLRDHGDVVRIKLGPKTVYAVTNPE-LTGALALNPDYHIAGPLWESLEGLLGKEGV 104 +F+ +GDV + LGP+ V + E + AL + ++ GV Sbjct: 35 SFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGV 94 Query: 105 ATANGPLHRRQRRTIQPAFRLDAIPAYG-------PIMEEEAHALTE--RWQPGKTVDAT 155 ANG + RR F + + +G ++EEA L E R G +D T Sbjct: 95 IFANGNRWKVLRR-----FSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPT 149 Query: 156 SESFRVAVRVAARCLL--RGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPAN 213 + + + R Y D+ + + +F + + G L+ L Sbjct: 150 FLFQSITANIICSIVFGKRFHYQDQE----FLKMLNLFYQTFSLISSVFGQLFELFSGFL 205 Query: 214 RRFNDALADLHLLVDEIIAERRASGQK---------PDDLLTALL----EAKDDNGDPIG 260 + F A ++ + EI A S +K P DL+ L + K + Sbjct: 206 KHFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPRDLIDTYLLHMEKEKSNAHSEFS 265 Query: 261 EQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTG-GRPVAFEDVR 319 Q ++ +++ G+ET ++T+ + + +P A+R+ E+E V G RP D Sbjct: 266 HQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRA 325 Query: 320 KLRHTGNVIVEAMRLRPAVWVLTRRAVAE-SELGGYRIPAGADIIYSPYAIQRDPKSYDD 378 K+ +T VI E R + + V + + GY IP ++ DP ++ Sbjct: 326 KMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEK 385 Query: 379 NLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKY 431 F+PD +L A A PFS GKR C + + A+L L + + Sbjct: 386 PDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNF 438 >5VBU-A nrPDB Length = 476 Score = 77.0 bits (188), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 82/340 (24%), Positives = 138/340 (40%), Gaps = 24/340 (7%) Query: 111 LHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERW--QPGKTVDATSESFRVAVRVAAR 168 L + ++ + A L + P++E+ ER QPG V E + + Sbjct: 97 LWKAHKKLTRSALLLGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICY 156 Query: 169 CLLRGQYMDER---AERLCVALATVFRGMYRRMVVPLGPLYRL-PLPANRRFNDALADLH 224 + D+ A C+ + +V + P R P P RR A+ Sbjct: 157 LTFGDKIKDDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQAIEKRD 216 Query: 225 LLVDEIIAERRAS---GQKPDDLLTALLE-----AKDDNGDPIGEQEIHDQVVAILTPGS 276 +V+ + + + S GQ D++ +L+ + ++ + E +H V +L G+ Sbjct: 217 HIVEMQLRQHKESLVAGQW-RDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGT 275 Query: 277 ETIASTIMWLLQALADHPEHADRIRDEVEAVTG----GRPVAFEDVRKLRHTGNVIVEAM 332 ET A+T+ W + L HPE R+++E++ G V ++D +L I E + Sbjct: 276 ETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVL 335 Query: 333 RLRPAV-WVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPER 391 RLRP V L R S + GY IP G II + D ++ EF PDR+L E Sbjct: 336 RLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFL-EP 394 Query: 392 AANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKY 431 N A F G R C + + +L ++ L + Sbjct: 395 GKNSRALA---FGCGARVCLGEPLARLELFVVLTRLLQAF 431 >1N6B-A nrPDB Length = 473 Score = 76.3 bits (186), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 59/224 (26%), Positives = 99/224 (44%), Gaps = 9/224 (4%) Query: 227 VDEIIAERRASGQK------PDDLLTA-LLEAKDDNGDPIGEQEIHDQVVAILTPGSETI 279 + I E+ QK P D + L++ + +N + + V + G+ET Sbjct: 222 IKNFIMEKVKEHQKLLDVNNPRDFIDCFLIKMEQENNLEFTLESLVIAVSDLFGAGTETT 281 Query: 280 ASTIMWLLQALADHPEHADRIRDEVEAVTG-GRPVAFEDVRKLRHTGNVIVEAMRLRPAV 338 ++T+ + L L HPE A R+++E+E V G R +D ++ +T VI E R + Sbjct: 282 STTLRYSLLLLLKHPEVAARVQEEIERVIGRHRSPCMQDRSRMPYTDAVIHEIQRFIDLL 341 Query: 339 WVLTRRAVA-ESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPK 397 AV + Y IP G DII S ++ D K++ + FDP +L E Sbjct: 342 PTNLPHAVTRDVRFRNYFIPKGTDIITSLTSVLHDEKAFPNPKVFDPGHFLDESGNFKKS 401 Query: 398 YAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSND 441 PFSAGKR C + + +L L ++ ++ + + D Sbjct: 402 DYFMPFSAGKRMCVGEGLARMELFLFLTSILQNFKLQSLVEPKD 445 >5JLC-A nrPDB Length = 515 Score = 75.9 bits (185), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 95/455 (20%), Positives = 182/455 (40%), Gaps = 59/455 (12%) Query: 24 PPVAGGGVPLLGHGWRLARDPLAFMSQL-RDHGDV---------VRIKLGPKTVYAVTNP 73 PP+ +P +G P F + +GD+ + + LGPK + N Sbjct: 38 PPLVFYWIPWVGSAIPYGTKPYEFFEDCQKKYGDIFSFMLLGRIMTVYLGPKGHEFIFNA 97 Query: 74 ELTGALALNPDYHIAGPLWESLEGLLGKEGVATANGPLHR--RQRRTIQPAFRLDAIPAY 131 +L A H+ P++ GK GV + P HR Q++ ++ A +A Y Sbjct: 98 KLADVSAEAAYSHLTTPVF-------GK-GV-IYDCPNHRLMEQKKFVKGALTKEAFVRY 148 Query: 132 GPIMEEEAHALTERWQPGKT-------VDATSESFRVAVRVAARCLLRGQYMDERAERLC 184 P++ EE + + K VD + + A+R LL + D+ Sbjct: 149 VPLIAEEIYKYFRNSKNFKINENNSGIVDVMVSQPEMTIFTASRSLLGKEMRDKLDTDFA 208 Query: 185 VALATVFRGMYRRMVVPLGPLY-RLPLPANRRFNDALADLHLLVDEIIAERRASGQKPD- 242 + + +G P+ ++ LPL R+ + A + +I ERR + Sbjct: 209 YLYSDLDKGF-----TPINFVFPNLPLEHYRKRDHAQQAISGTYMSLIKERREKNDIQNR 263 Query: 243 DLLTALLE-AKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIR 301 DL+ L++ + +G + +QEI + ++ +L G T A+T W L LA+ P+ + + Sbjct: 264 DLIDELMKNSTYKDGTKMTDQEIANLLIGVLMGGQHTSAATSAWCLLHLAERPDVQEELY 323 Query: 302 DEVEAVTGG--RPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESEL--GGYRIP 357 E V + + ++D++ + +I E +RL + L R+ + + + Y +P Sbjct: 324 QEQMRVLNNDTKELTYDDLQNMPLLNQMIKETLRLHHPLHSLFRKVMRDVAIPNTSYVVP 383 Query: 358 AGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVP------KYAMK---------- 401 ++ SP + + EF+ RW + A++ Y Sbjct: 384 RDYHVLVSPGYTHLQEEFFPKPNEFNIHRWDGDAASSSAAGGDEVDYGFGAISKGVSSPY 443 Query: 402 -PFSAGKRKCPSDHFSMAQLTLITAAL--ATKYRF 433 PF G+ +C + F+ QL ++ + K+R+ Sbjct: 444 LPFGGGRHRCIGELFAYCQLGVLMSIFIRTMKWRY 478 >3QZ1-A nrPDB Length = 496 Score = 73.9 bits (180), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 68/246 (27%), Positives = 109/246 (44%), Gaps = 17/246 (6%) Query: 199 VVPLGPLYRL-PLPANRRFNDALADLHLLVDEII---AERRASGQ---KPDDLLTALLEA 251 ++ + P R P P R A+ + +V++ + E +GQ D +L + Sbjct: 207 ILDMVPFLRFFPNPGLWRLKQAIENRDHMVEKQLRRHKESMVAGQWRDMTDYMLQGVGRQ 266 Query: 252 KDDNG-DPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTG- 309 + + G + E +H VV + G+ET AST+ W + L HPE R+++E++ G Sbjct: 267 RVEEGPGQLLEGHVHMSVVDLFIGGTETTASTLSWAVAFLLHHPEIQRRLQEELDRELGP 326 Query: 310 ---GRPVAFEDVRKLRHTGNVIVEAMRLRPAV-WVLTRRAVAESELGGYRIPAGADIIYS 365 V ++D +L I E +RLRP V L R S + GY IP G +I + Sbjct: 327 GASCSRVTYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSIFGYDIPEGMVVIPN 386 Query: 366 PYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITA 425 D ++ EF PDR+L E AN A F G R C + + +L ++ A Sbjct: 387 LQGAHLDETVWEQPHEFRPDRFL-EPGANPSALA---FGCGARVCLGESLARLELFVVLA 442 Query: 426 ALATKY 431 L + Sbjct: 443 RLLQAF 448 >5E0E-A nrPDB Length = 463 Score = 71.6 bits (174), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 91/419 (21%), Positives = 171/419 (40%), Gaps = 32/419 (7%) Query: 40 LARDPLAFMSQLR----DHGDVVRIKLGPKTVYAVTNPE-LTGALALNPDYHIAGPLWES 94 L D F++ R +GDV + LGP+ V + E + AL + Sbjct: 16 LQMDRGGFLNSFRRIREKYGDVFTVHLGPRPVVMLYGTEAIREALVDQAEAFSGRGTIAV 75 Query: 95 LEGLLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYG-------PIMEEEAHALTERWQ 147 +E + GV ANG + RR F L + +G ++EEA L E ++ Sbjct: 76 VEPIFRGYGVVFANGERWKALRR-----FSLVTMRDFGMGKRSVEERIQEEARCLVEEFR 130 Query: 148 P--GKTVDATSESFRVAVRVAARCLL--RGQYMDERAERLCVAL--ATVFRGMYRRMVVP 201 G +D T + + + R Y D + RL + + V Sbjct: 131 KSQGAPLDPTFLFQCITANIICSIVFGERFDYKDHQFLRLLYLFYQSFSLISSFSSQVFE 190 Query: 202 LGPLYRLPLPA-NRRFNDALADLHLLVDEIIAERRASG--QKPDDLL-TALLEAKDDNGD 257 L + P +R+ + L ++ + + + + RA+ P D + T LL + + + Sbjct: 191 LFSGFLKYFPGTHRQISRNLQEILDYIGQSVEKHRATLDPSHPRDFIDTYLLRMEKEKSN 250 Query: 258 PIGEQEIHDQVVAILT---PGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGG-RPV 313 E + + V+++L+ G+ET ++T+ + + +P A++++ E++ V G R Sbjct: 251 QHTEFDHQNLVISVLSLFFAGTETSSTTLRYGFLLMLKYPHVAEKVQKEIDQVIGSHRLP 310 Query: 314 AFEDVRKLRHTGNVIVEAMRLRPAVWV-LTRRAVAESELGGYRIPAGADIIYSPYAIQRD 372 ED K+ +T VI E R + + + + ++ GY +P ++ + D Sbjct: 311 TLEDRTKMPYTEAVIYEIQRFSDLIPIGVPHKVTKDTLFRGYLLPKNTEVYPILSSALHD 370 Query: 373 PKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKY 431 P+ ++ F+PD +L A A PFS GKR C + + +L L + + Sbjct: 371 PQYFEQPDTFNPDHFLDANGALKKSEAFMPFSIGKRICLGEGIARNELFLFFTTILQNF 429 >4R1Z-A nrPDB Length = 439 Score = 71.6 bits (174), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 59/229 (25%), Positives = 103/229 (44%), Gaps = 15/229 (6%) Query: 243 DLLTALLEAK---DDNGDP-----IGEQEIHDQVVAILTPGSETIASTIMWLLQALADHP 294 DLL ALL AK ++N + E + V I G ET + + W + L +P Sbjct: 194 DLLDALLRAKRSSENNNSSTRDVGLTEDHVLMTVGDIFGAGVETTTTVLKWSIAYLVHNP 253 Query: 295 EHADRIRDEVEAVTGG-RPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLT-RRAVAESELG 352 + +I++E+++ G R D L + I E +R+RP +L A+ +S +G Sbjct: 254 QVQRKIQEELDSKIGKERHPQLSDRGNLPYLEATIREVLRIRPVSPLLIPHVALQDSSVG 313 Query: 353 GYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANV--PKYAMKPFSAGKRKC 410 Y + G ++ + +++ D K + + FDP R+L E + P + PF AG R C Sbjct: 314 EYTVQKGTRVVINLWSLHHDKKEWKNPELFDPGRFLNEEGDGLCCPSGSYLPFGAGVRVC 373 Query: 411 PSDHFSMAQLTLITAALATKYRFEQVAGS---NDAVRVGITLRPHDLLV 456 + + +L L A + ++ E G + + G+ L+P V Sbjct: 374 LGEALAKMELFLFLAWILQRFTLEMPTGQPLPDLQGKFGVVLQPKKFKV 422 >6IQ5-A nrPDB Length = 463 Score = 71.6 bits (174), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 69/278 (24%), Positives = 118/278 (42%), Gaps = 24/278 (8%) Query: 201 PLGPLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEA--KDDNGDP 258 P+ ++R NR F++ + D L E G P D++ A + + K GD Sbjct: 186 PVRTVFREFEQLNRNFSNFILDKFLR----HCESLRPGAAPRDMMDAFILSAEKKAAGDS 241 Query: 259 IGE------QEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTG-GR 311 G + + + I +T+++ + WLL +P+ R++ E++ V G R Sbjct: 242 HGGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDR 301 Query: 312 PVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAV-AESELGGYRIPAGADIIYSPYAIQ 370 D L + + EAMR V V A A + + GY IP + + +++ Sbjct: 302 LPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVN 361 Query: 371 RDPKSYDDNLEFDPDRWLPERA---ANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAAL 427 DP + + FDP R+L + ++ M FS GKR+C + S QL L + L Sbjct: 362 HDPVKWPNPENFDPARFLDKDGLINKDLTSRVMI-FSVGKRRCIGEELSKMQLFLFISIL 420 Query: 428 ATKYRFEQVAGSNDAVRV----GITLRPHDLLVRPVAR 461 A + F A N+ ++ G+T++P V R Sbjct: 421 AHQCDFR--ANPNEPAKMNFSYGLTIKPKSFKVNVTLR 456 >2NNH-A nrPDB Length = 476 Score = 70.9 bits (172), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 84/360 (23%), Positives = 143/360 (39%), Gaps = 35/360 (9%) Query: 103 GVATANGPLHRRQRRTIQPAFRLDAIPAYG-------PIMEEEAHALTERWQPGKTVDAT 155 G+ ++NG + RR F L + +G ++EEAH L E + K Sbjct: 93 GIISSNGKRWKEIRR-----FSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCD 147 Query: 156 SESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPL------GPLYRLP 209 C + Q + ++ + L F +R + P PL Sbjct: 148 PTFILGCAPCNVICSVVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDC 207 Query: 210 LPANRRFNDALADLHL---LVDEIIAERRAS--GQKPDDLLTALL----EAKDDNGDPIG 260 P N L ++ L + E + E +AS P D + L + KD+ Sbjct: 208 FPGTH--NKVLKNVALTRSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFN 265 Query: 261 EQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTG-GRPVAFEDVR 319 + + V + G+ET ++T+ + L L HPE ++++E++ V G R +D Sbjct: 266 IENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRS 325 Query: 320 KLRHTGNVIVEAMRLRPAVWVLTRRAVA-ESELGGYRIPAGADIIYSPYAIQRDPKSYDD 378 + +T V+ E R V AV +++ Y IP G I+ ++ D K + + Sbjct: 326 HMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPN 385 Query: 379 NLEFDPDRWLPERAANVPK--YAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQV 436 FDP +L ++ N K Y M PFSAGKR C + + +L L + + + V Sbjct: 386 PNIFDPGHFL-DKNGNFKKSDYFM-PFSAGKRICAGEGLARMELFLFLTTILQNFNLKSV 443 >5W0C-A nrPDB Length = 477 Score = 68.2 bits (165), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 49/200 (24%), Positives = 86/200 (43%), Gaps = 6/200 (3%) Query: 242 DDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIR 301 D L + + K + + + + V + G+ET ++T+ + L L HPE +++ Sbjct: 248 DCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQ 307 Query: 302 DEVEAVTG-GRPVAFEDVRKLRHTGNVIVEAMR---LRPAVWVLTRRAVAESELGGYRIP 357 +E+E V G R +D + +T V+ E R L P L + + Y IP Sbjct: 308 EEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTS--LPHAVTCDIKFRNYLIP 365 Query: 358 AGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSM 417 G I+ S ++ D K + + FDP +L E PFSAGKR C + + Sbjct: 366 KGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAG 425 Query: 418 AQLTLITAALATKYRFEQVA 437 +L L ++ + + + Sbjct: 426 MELFLFLTSILQNFNLKSLV 445 >4GQS-A nrPDB Length = 477 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 56/236 (23%), Positives = 102/236 (43%), Gaps = 11/236 (4%) Query: 217 NDALADLHLLVDEIIAERRASGQ-----KPDDLLTA-LLEAKDDNGDPIGEQEIHDQVVA 270 N L +L + +I+ + + + P D + L++ + + + E I + V+ Sbjct: 214 NKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVIT 273 Query: 271 ---ILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTG-GRPVAFEDVRKLRHTGN 326 +L G+ET ++T+ + L L HPE ++++E+E V G R +D + +T Sbjct: 274 AADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDA 333 Query: 327 VIVEAMRLRPAVWVLTRRAV-AESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPD 385 V+ E R + AV + + Y IP G I+ S ++ D K + + FDP Sbjct: 334 VVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPR 393 Query: 386 RWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSND 441 +L E PFSAGKR C + + +L L + + + + D Sbjct: 394 HFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKD 449 >3N9Z-A nrPDB Length = 487 Score = 66.2 bits (160), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 52/194 (26%), Positives = 84/194 (43%), Gaps = 8/194 (4%) Query: 262 QEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAV----TGGRPVAFED 317 ++I V +L G +T + T+ W L +A + + D +R EV A G + Sbjct: 274 EDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQL 333 Query: 318 VRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYD 377 V L+ + I E +RL P L R V + L Y IPA + + YA+ R+P + Sbjct: 334 VPLLKAS---IKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFF 390 Query: 378 DNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVA 437 D FDP RWL + N+ + F G R+C + ++T+ + +R E Sbjct: 391 DPENFDPTRWL-SKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQH 449 Query: 438 GSNDAVRVGITLRP 451 S+ + L P Sbjct: 450 LSDVGTTFNLILMP 463 >4JBT-A nrPDB Length = 410 Score = 65.1 bits (157), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 105/402 (26%), Positives = 160/402 (39%), Gaps = 66/402 (16%) Query: 49 SQLRDHGDVVRIKLGPKTVYAVTNPELTGALA----LNPDYHIAGPLWES--------LE 96 S+LR G + RI L AVT L L L D + A LW+S L Sbjct: 24 SRLRAAGPLTRIDLLGVPALAVTGHTLARQLLTDTRLVKDIN-AWSLWQSGTVTRQWPLI 82 Query: 97 GLLGKE-GVATANGPLHRRQRRTIQPAF---RLDAI-PAYGPIMEEEAHALTERWQPGKT 151 G++ + + T +GP HRR R A RLDA+ P + E L G Sbjct: 83 GMIDVDRSMFTVDGPEHRRLRIKTTQALTRRRLDALKPTIERYVAELLDDLERAGADGAV 142 Query: 152 VDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLP 211 VD L+ + R+ AL V +++ + + P Sbjct: 143 VD-----------------LKSVFAYPLPMRVISALMGVPSEDQEQLLTWYKAFFSILTP 185 Query: 212 ANRRFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAI 271 + R + ++H E++ RR + + DDL +AL+ A D P+ E+E+ + A+ Sbjct: 186 QDERLR-VIDEMHGYFTEMV--RRKTAEPGDDLTSALIYATDGE-TPLTEEEVIGNLQAL 241 Query: 272 LTPGSETIASTIMWLLQALADHPEHADRIRD-EVEAVTGGRPVAFEDVRKLRHTGNVIVE 330 + G ET S I+ ++AL HPE +RD E+ G A E+ LR G Sbjct: 242 VAAGHETTVSLILTAVRALLSHPEQLRLVRDGEI-----GWETAIEET--LRWDG----- 289 Query: 331 AMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYD-DNLEFDPDRWLP 389 P + +L R A + +LG IP G ++ S AI RD + D +FD R Sbjct: 290 -----PVIHLLMRFATEDIDLGDAVIPRGEGVVMSYRAIGRDITVHGADADDFDITRATA 344 Query: 390 ERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKY 431 R + F G CP + + + AL T++ Sbjct: 345 ARHIS--------FGHGPHICPGAALARLEAAIALPALFTRF 378 >3WVS-A nrPDB Length = 401 Score = 64.7 bits (156), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 74/280 (26%), Positives = 120/280 (42%), Gaps = 36/280 (12%) Query: 108 NGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTE-RWQPGKTVDATSESFRVAVRVA 166 + P H R RR I AF + + P + + AH L + G+ D ++ + + + Sbjct: 94 DAPDHTRLRRLISKAFTIRRVEELRPKVHDLAHRLIDDMLAKGEPADLVAD-YALPIPTT 152 Query: 167 ARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALADLHLL 226 C L G ++R + G + ++ L P R +L Sbjct: 153 VICELLGVPFEDREKF----------GRWTDAILSTSTLN----PEEGRVKRM--ELVGY 196 Query: 227 VDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWL 286 + IIA RRA Q DDL++ ++EA+D D + EQE+ D + +L G ET AS I Sbjct: 197 IGGIIAARRA--QPADDLISGMIEARDVQ-DKLTEQELLDHCIGLLIAGHETTASQIPSF 253 Query: 287 LQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAV 346 + AL D P+H R+ D+ E + P A E++ + G+ R A Sbjct: 254 VYALLDQPQHWKRLLDDPELI----PSAVEELFRFVPLGSGSAAP-----------RYAR 298 Query: 347 AESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDR 386 + E+GG + AG ++ + A RD ++D E DR Sbjct: 299 EDIEVGGTLVRAGEPVLVALGAANRDGLRFEDPEEIKLDR 338 >5CJE-A nrPDB Length = 393 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 89/367 (24%), Positives = 141/367 (38%), Gaps = 47/367 (12%) Query: 28 GGGVPLLGHGWRLARDPLAFMSQLRDHGDVVRIKLGPKTVY----AVTNPELTGALA--- 80 G + L +G R DP ++LR+ G V ++ P + V + E ALA Sbjct: 2 GNVIDLGEYGARFTEDPYPVYAELRERGPVHWVRTPPPEAFEGWLVVGHEEARAALADPR 61 Query: 81 LNPDYHIAGPLWESLEGLLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAH 140 L+ D G SL+ L + + P H R R + AF + + A P ++E Sbjct: 62 LSKDGTKKG--LTSLDVELMGPYLLVVDPPEHTRLRSLVARAFTMRRVEALRPRIQEITD 119 Query: 141 ALTERWQPGKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVV 200 L + P D +SF + + C L G +R FR + +V Sbjct: 120 GLLDEMLPRGRADLV-DSFAYPLPITVICELLGVPDIDR---------VTFRALSNEIVA 169 Query: 201 PLGPLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIG 260 P G L A L +DE+I ++R++ DDLL L+ + ++ D + Sbjct: 170 PTGGDAELA---------AYERLAAYLDELIDDKRSTAPA-DDLLGDLIRTRAEDDDRLS 219 Query: 261 EQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRK 320 +E+ +L G ET + I + L HP+ +R ++ + G Sbjct: 220 GEELRAMAFILLVAGHETTVNLITNGVHTLLTHPDQLAALRADMTLLDGA---------- 269 Query: 321 LRHTGNVIVEAMRLRPAVWVLTRRAVAE-SELGGYRIPAGADIIYSPYAIQRDPKSYDDN 379 + E +R V T R AE E+GG I G ++ A RDP + D Sbjct: 270 -------VEEVLRFEGPVETATYRYAAESMEIGGTAIAEGDPVMIGLDAAGRDPARHPDP 322 Query: 380 LEFDPDR 386 FD R Sbjct: 323 HVFDIHR 329 >4WPZ-A nrPDB Length = 397 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 88/338 (26%), Positives = 134/338 (39%), Gaps = 52/338 (15%) Query: 88 AGPLWESLEGLLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGP-IMEEEAHALTERW 146 A + E+ G L E + + P H R R+ + AF + P I E L E Sbjct: 66 AAAMSETETGKLMNESLVGMDAPEHTRLRKLVTKAFTARRVETLRPRITELVGQLLDELE 125 Query: 147 QPGKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLY 206 + VD ++F V + V C L G + + A + G ++++V Sbjct: 126 TLPRPVDLV-KNFSVPLPVRVICELLGVPAGD--QDTFHAWSNALLGDWQQVV------- 175 Query: 207 RLPLPANRRFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHD 266 A L E+IA +R + P D L + L A D + E+EI Sbjct: 176 --------EKEAATVSLVNYFGELIAVKR---ENPADDLISELIAISDGDSTLTEREIIA 224 Query: 267 QVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRK---LRH 323 + IL+ G ET A+ I L L +PE D++RD EA+ P A +++ + L Sbjct: 225 LSIGILSAGHETTANQISMFLVTLLHNPEELDKLRDNREAI----PKAVDELLRFVPLTT 280 Query: 324 TGNVIVEAMRLRPAVWVLTRRAVAESEL-GGYRIPAGADIIYSPYAIQRDPKSYDDNLEF 382 TG +I R AE EL GG +PAGA ++ + RDP+ ++D Sbjct: 281 TGGII-------------PRLTTAEVELSGGQVLPAGAVVLPAVATANRDPEVFEDGERL 327 Query: 383 DPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQL 420 + R N P A F AG C + +L Sbjct: 328 NVTR------ENNPHLA---FGAGIHHCLGAQLARIEL 356 >3SN5-A nrPDB Length = 491 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 105/477 (22%), Positives = 176/477 (36%), Gaps = 65/477 (13%) Query: 23 EPPVAGGGVPLLGHGWRLARDPLAFM-SQLRDHGDVVRIKLGPKTVYAVTNPELTGALAL 81 EPP+ G +P LG + +PL F+ + R HG V KL K V+ +TNP + Sbjct: 14 EPPLENGLIPYLGCALQFGANPLEFLRANQRKHGHVFTCKLMGKYVHFITNPLSYHKVLC 73 Query: 82 NPDYHIAGPLWESLEG-LLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEE-- 138 + Y +L G + +G T + A+ + M E Sbjct: 74 HGKYFDWKKFHFALSAKAFGHRSIDPMDGNTTENINDTFIKTLQGHALNSLTESMMENLQ 133 Query: 139 --------AHALTERWQPGKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATV 190 +++ T W T S +RV A + G+ + R + L + Sbjct: 134 RIMRPPVSSNSKTAAWV---TEGMYSFCYRVMFE-AGYLTIFGRDLTRRDTQKAHILNNL 189 Query: 191 -----FRGMYRRMVVPLG-PLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQKPDDL 244 F ++ +V L ++R A + ++L +L E I+E + +D Sbjct: 190 DNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESLRHENLQKRESISELISLRMFLNDT 249 Query: 245 LTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEV 304 L+ D + + + H +V + + TI +T W L + +PE +EV Sbjct: 250 LSTF--------DDLEKAKTH--LVVLWASQANTIPATF-WSLFQMIRNPEAMKAATEEV 298 Query: 305 EAV--TGGRPVAFE---------DVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAES---- 349 + G+ V+ E ++ L ++I E++RL A L R E Sbjct: 299 KRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSAS--LNIRTAKEDFTLH 356 Query: 350 -ELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVP---------KYA 399 E G Y I I P + DP+ Y D L F DR+L E KY Sbjct: 357 LEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYY 416 Query: 400 MKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSN-----DAVRVGITLRP 451 PF +G CP F++ ++ + + + E + G D R G+ + P Sbjct: 417 YMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQSRAGLGILP 473 >6A7J-A nrPDB Length = 411 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 61/214 (28%), Positives = 97/214 (45%), Gaps = 31/214 (14%) Query: 220 LADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETI 279 +ADL L +I+ E++A+ P D LT+ L A ++GD + ++EI + + I+ G ET Sbjct: 189 MADLGTLFTKIVEEKKAN---PGDDLTSALIAASEDGDHLTDEEILNTLQLIIAAGHETT 245 Query: 280 ASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLR-PAV 338 S I+ +++ALA HPE ++ ++G P VI E +R P Sbjct: 246 ISLIVNVVEALAIHPEQRKKV------LSGEIPWE-----------GVIEETLRWNTPTS 288 Query: 339 WVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNL-EFDPDRWLPERAANVPK 397 VL R A + E+G +P G ++ S A+ RD + Y +FD R P R Sbjct: 289 HVLIRFATEDIEVGDKVLPKGEGLVVSFGALGRDEEQYGPTAGDFDATR-TPNRHI---- 343 Query: 398 YAMKPFSAGKRKCPSDHFSMAQLTLITAALATKY 431 F G CP S + + AL ++ Sbjct: 344 ----AFGHGPHVCPGAALSRLEAGIALPALYERF 373 >6A7I-A nrPDB Length = 411 Score = 62.4 bits (150), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 61/214 (28%), Positives = 92/214 (42%), Gaps = 31/214 (14%) Query: 220 LADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETI 279 +ADL L +I+ +R + P D LT+ L A +NGD + ++EI + + I+ G ET Sbjct: 189 MADLGALFTKIVDAKRTN---PGDDLTSALIAASENGDHLTDEEIVNTLQLIIAAGHETT 245 Query: 280 ASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLR-PAV 338 S I+ +++AL HPE ++ + G VI E +R P Sbjct: 246 ISLIVNVVEALQTHPEQRKKVLNGEIGWDG-----------------VIEETLRWNTPTS 288 Query: 339 WVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNL-EFDPDRWLPERAANVPK 397 VL R A + E+G +P G +I S A+ RD + Y EFD R P R Sbjct: 289 HVLIRFATEDIEVGDKILPKGEGLIISFGALGRDEEQYGPTAGEFDATR-TPNRHI---- 343 Query: 398 YAMKPFSAGKRKCPSDHFSMAQLTLITAALATKY 431 F G CP S + + AL ++ Sbjct: 344 ----AFGHGPHVCPGAALSRLEAGIALPALYERF 373 >1ODO-A nrPDB Length = 408 Score = 61.2 bits (147), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 100/398 (25%), Positives = 162/398 (40%), Gaps = 63/398 (15%) Query: 51 LRDHGDVVRIKLGPKTVYAVTNPELTGALALNPDYHI-AGPLWESLEGLLGK-------- 101 LR+ G + + ++V++P L L + D A W + ++G Sbjct: 24 LREGGPATWVDVLGVQAWSVSDPVLLKQLLTSSDVSKDARAHWPAFGEVVGTWPLALWVA 83 Query: 102 -EGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQ---PGKTVDATSE 157 E + TA GP HR+ RR + PAF + A P +E L +R G+ VD E Sbjct: 84 VENMFTAYGPNHRKLRRLVAPAFSARRVDAMRPAVEAMVTGLVDRLAELPAGEPVDLRQE 143 Query: 158 SFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFN 217 + +A L G D R + G++ L + AN Sbjct: 144 -LAYPLPIAVIGHLMGVPQDRRD-----GFRALVDGVFDTT------LDQAEAQANT--- 188 Query: 218 DALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDD--NGDPIGEQEIHDQVVAILTPG 275 A L+ ++D++IA +RA+ DD+ + L+ A+DD +GD + +E+ D ++ +++ G Sbjct: 189 ---ARLYEVLDQLIAAKRAT--PGDDMTSLLIAARDDEGDGDRLSPEELRDTLLLMISAG 243 Query: 276 SETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLR 335 ET + I + L P D++ V G V + D V+ E +R Sbjct: 244 YETTVNVIDQAVHTLLTRP-------DQLALVRKGE-VTWAD---------VVEETLRHE 286 Query: 336 PAVWVL-TRRAVAESEL-GGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAA 393 PAV L R AV + L G I G I+ S A R P ++D FD R + E A Sbjct: 287 PAVKHLPLRYAVTDIALPDGRTIARGEPILASYAAANRHPDWHEDADTFDATRTVKEHLA 346 Query: 394 NVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKY 431 F G C + ++TL +L ++ Sbjct: 347 ---------FGHGVHFCLGAPLARMEVTLALESLFGRF 375 >3MZS-A nrPDB Length = 486 Score = 60.5 bits (145), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 104/476 (21%), Positives = 179/476 (37%), Gaps = 50/476 (10%) Query: 24 PPVAGGGVPLLGHGWR---LARDPLAFMSQLRDHGDVVRIKLGP-KTVYAVTNPELTGAL 79 P G L H WR R + + +G + R KLG ++VY + ++ Sbjct: 14 PSPGDNGWLNLYHFWREKGSQRIHFRHIENFQKYGPIYREKLGNLESVYIIHPEDVAHLF 73 Query: 80 ALNPDY--HIAGPLWESLEGLLGKE-GVATANGPLHRRQR-----RTIQPAFRLDAIPAY 131 Y P W + K GV ++ R + P + IP Sbjct: 74 KFEGSYPERYDIPPWLAYHRYYQKPIGVLFKKSGTWKKDRVVLNTEVMAPEAIKNFIPLL 133 Query: 132 GPIMEEEAHALTERWQ---PGKTV-DATSESFRVA------VRVAARCLLRGQYMDERAE 181 P+ ++ L +R + GK V D + F A V R + + ++ A+ Sbjct: 134 NPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQ 193 Query: 182 RLCVALATVFRGMYRRMVVPLGPLYRLPLPANRR---------FNDALADLHLLVDEIIA 232 + A+ +F + VP LYRL R FN A + ++ Sbjct: 194 KFIDAVYKMFHTSVPLLNVP-PELYRLFRTKTWRDHVAAWDTIFNKAEKYTEIFYQDL-- 250 Query: 233 ERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALAD 292 R+ + +L LL++ + + +++ + +L G T + T+ W L +A Sbjct: 251 RRKTEFRNYPGILYCLLKS-----EKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMAR 305 Query: 293 HPEHADRIRDEVEAVTGGRPVAFEDVRKLRHT----GNVIVEAMRLRPAVWVLTRRAVAE 348 + +R+EV R A D+ K+ I E +RL P L R ++ Sbjct: 306 SLNVQEMLREEV---LNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPESD 362 Query: 349 SELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKR 408 L Y IPA + + YA+ RDP + +FDP RWL + ++ + F G R Sbjct: 363 LVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWL-SKDKDLIHFRNLGFGWGVR 421 Query: 409 KCPSDHFSMAQLTLITAALATKYRFE-QVAGSNDAVRVGITL--RPHDLLVRPVAR 461 +C + ++TL + ++ E Q G D + I +P L+ RP + Sbjct: 422 QCVGRRIAELEMTLFLIHILENFKVEMQHIGDVDTIFNLILTPDKPIFLVFRPFNQ 477 >1Z8P-A nrPDB Length = 404 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 70/284 (24%), Positives = 117/284 (41%), Gaps = 36/284 (12%) Query: 103 GVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDATSESFRVA 162 + T++ P H R R+ + F + + A P +E+ L + VD + F Sbjct: 89 NMGTSDPPTHTRLRKLVSQEFTVRRVEAMRPRVEQITAELLDEVGDSGVVDIV-DRFAHP 147 Query: 163 VRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALAD 222 + + C L G +DE+ +RG + R + L P A +R A Sbjct: 148 LPIKVICELLG--VDEK-----------YRGEFGRWSSEI--LVMDPERAEQRGQAAREV 192 Query: 223 LHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIAST 282 ++ ++D + ERR + + DDLL+AL+ +DD+ + E+ + +L G E+ S Sbjct: 193 VNFILD--LVERRRT-EPGDDLLSALIRVQDDDDGRLSADELTSIALVLLLAGFESSVSL 249 Query: 283 IMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLT 342 I L HP+ +R + A+ N + E +R T Sbjct: 250 IGIGTYLLLTHPDQLALVRRDPSALP-----------------NAVEEILRYIAPPETTT 292 Query: 343 RRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDR 386 R A E E+GG IP + ++ + A RDPK + D FD R Sbjct: 293 RFAAEEVEIGGVAIPQYSTVLVANGAANRDPKQFPDPHRFDVTR 336 >4Z5P-A nrPDB Length = 400 Score = 58.5 bits (140), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 56/211 (26%), Positives = 95/211 (45%), Gaps = 27/211 (12%) Query: 221 ADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIA 280 A + + ++++ RRA+ DDLL L+ A+DD+ D + E E+ V +L G ET A Sbjct: 187 ASIRAYLADLVSARRAAPH--DDLLGVLVSARDDD-DRLTEDELITFGVTLLVAGHETSA 243 Query: 281 STIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWV 340 + ++ AL H + +R++ E + P A E++ + GN + A Sbjct: 244 HQLGNMVYALLTHEDQLSLLREQPELL----PRAVEELLRFVPLGNGVGNA--------- 290 Query: 341 LTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAM 400 R A+ + EL G + AG ++ + RDP+++D DPDR R N P A Sbjct: 291 --RIALEDVELSGGTVRAGEGVVAAAVNANRDPRAFD-----DPDRLDITREKN-PHLA- 341 Query: 401 KPFSAGKRKCPSDHFSMAQLTLITAALATKY 431 F G C + +L + L ++ Sbjct: 342 --FGHGAHYCLGAQLARMELRVAIGGLLERF 370 >4Z5Q-A nrPDB Length = 423 Score = 58.5 bits (140), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 83/326 (25%), Positives = 133/326 (40%), Gaps = 43/326 (13%) Query: 102 EGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDATSESFRV 161 E + T + P H R R + AF I + + E A L + G S+ + Sbjct: 110 ESILTMDPPDHTRLRTLVSKAFTPRRIESKRAWIGELAAGLVADMKAGGAPAELVGSYAL 169 Query: 162 AVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALA 221 A+ V C L G D+R T RG + + G L + + Sbjct: 170 AIPVTVICELLGVPEDDR---------TRLRG-WCDAALSTGEL------TDEECVQSFM 213 Query: 222 DLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIAS 281 DL ++++ ERRA + DDL +AL+EA+D + D + E E+ ++IL G ET AS Sbjct: 214 DLQKYFEDLVKERRA--EPRDDLTSALIEARDAH-DRLAEPELIGLCISILIGGFETTAS 270 Query: 282 TIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVL 341 I + L E R+ + EA+ P A E++ + V A + P Sbjct: 271 EISSFVHVLQQRRELWTRLCADPEAI----PAAVEELLRF-----VPFAANGISP----- 316 Query: 342 TRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMK 401 R A+ + +GG + G +I A+ RD +D + D + +RA N ++ + Sbjct: 317 -RYALEDMTVGGVLVREGEPVIVDTSAVNRDGLVFD-----NADEVVIDRADN--RHMV- 367 Query: 402 PFSAGKRKCPSDHFSMAQLTLITAAL 427 F G C H + +L AL Sbjct: 368 -FGHGAHHCLGAHLARVELQEALKAL 392 >1CPT-A nrPDB Length = 428 Score = 54.7 bits (130), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 58/246 (23%), Positives = 105/246 (42%), Gaps = 29/246 (11%) Query: 212 ANRRFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAI 271 A RRF++ +A + + +RR+ + DD+++ L +K D G+ I ++ I+ VAI Sbjct: 208 AARRFHETIATFYDYFNGFTVDRRSCPK--DDVMSLLANSKLD-GNYIDDKYINAYYVAI 264 Query: 272 LTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEA 331 T G +T +S+ + L+ +PE A+ P ++ EA Sbjct: 265 ATAGHDTTSSSSGGAIIGLSRNPEQL--------ALAKSDPALIP---------RLVDEA 307 Query: 332 MRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPER 391 +R V R A+A++E+ G I G I+ S + RD + + + EFD R+ P R Sbjct: 308 VRWTAPVKSFMRTALADTEVRGQNIKRGDRIMLSYPSANRDEEVFSNPDEFDITRF-PNR 366 Query: 392 AANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRVGITLRP 451 F G C H + ++ + L K + +++G V P Sbjct: 367 HLG--------FGWGAHMCLGQHLAKLEMKIFFEELLPKLKSVELSGPPRLVATNFVGGP 418 Query: 452 HDLLVR 457 ++ +R Sbjct: 419 KNVPIR 424 >3P3Z-A nrPDB Length = 416 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 56/215 (26%), Positives = 86/215 (40%), Gaps = 29/215 (13%) Query: 226 LVDEIIAERRASGQKP-DDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIM 284 + D ++A +P DDL + ++ A D + + E+ V +L G ET + Sbjct: 206 MFDYLVAAIEKRKVEPGDDLTSDIVRAFHDG--VLDDYELRTLVATVLVAGYETTNHQLA 263 Query: 285 WLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRR 344 + A HP+ +I++ E P A E+V +R P + V R Sbjct: 264 LAMYDFAQHPDQWMKIKENPELA----PQAVEEV-------------LRWSPTLPVTATR 306 Query: 345 AVAES-ELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPF 403 AE E+ G RIP G + + RDP+ + D DR+ P A F Sbjct: 307 VAAEDFEVNGVRIPTGTPVFMCAHVAHRDPRVFADA-----DRFDITVKREAPSIA---F 358 Query: 404 SAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAG 438 G C + +LT AALAT+ Q+AG Sbjct: 359 GGGPHFCLGTALARLELTEAVAALATRLDPPQIAG 393 >3ABB-A nrPDB Length = 408 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 81/329 (24%), Positives = 121/329 (36%), Gaps = 59/329 (17%) Query: 108 NGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEA-HALTERWQPGKTVDATSESFRVAVRVA 166 + P+H RQRR + P+F + + A P ++ L + G D S +F + V Sbjct: 98 DDPVHARQRRMLIPSFGVKRMNAIRPRLQSLVDRLLDDMLAKGPGADLVS-AFALPVPSV 156 Query: 167 ARCLLRGQ-YMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALADLHL 225 A C L G Y D C + F G A+ F + LH Sbjct: 157 AICELLGVPYGDHDFFEEC---SRNFVGAATSAE------------ADAAFGELYTYLHG 201 Query: 226 LVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAI----LTPGSETIAS 281 LV R + D LL L+ + + GD HD+VV I L G ET + Sbjct: 202 LVG------RKQAEPEDGLLDELIARQLEEGD-----LDHDEVVMIALVLLVAGHETTVN 250 Query: 282 TIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVL 341 I L HPE D + + AV+G V+ E +R + Sbjct: 251 AIALGALTLIQHPEQIDVLLRDPGAVSG-----------------VVEELLRFTSVSDHI 293 Query: 342 TRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMK 401 R A + E+GG I AG ++ S + RD K+Y++ FD R Sbjct: 294 VRMAKEDIEVGGATIKAGDAVLVSITLMNRDAKAYENPDIFDARRNARHHVG-------- 345 Query: 402 PFSAGKRKCPSDHFSMAQLTLITAALATK 430 F G +C + + A+L + L + Sbjct: 346 -FGHGIHQCLGQNLARAELEIALGGLFAR 373 >5OFQ-A nrPDB Length = 409 Score = 53.1 bits (126), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 44/178 (24%), Positives = 82/178 (46%), Gaps = 25/178 (14%) Query: 217 NDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGS 276 N+ + L EIIAER+ + Q +DL++ LLEA+ D G+ + E+E+ + +L G+ Sbjct: 187 NEGVIFLQGYFKEIIAERQQNKQ--EDLISLLLEAEID-GEHLTEEEVLGFCILLLVAGN 243 Query: 277 ETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRP 336 ET + I ++ + + + + +R ++ V N++ E +R P Sbjct: 244 ETTTNLITNGVRYMTEDVDVQNEVRRDISLVP-----------------NLVEETLRYYP 286 Query: 337 AVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAAN 394 + + R A + ELG +I G +I + RD ++ PD ++ R N Sbjct: 287 PIQAIGRIAAEDVELGECKIKRGQQVISWAASANRDSAKFE-----WPDTFVVHRKTN 339 >3EJB-B nrPDB Length = 404 Score = 52.0 bits (123), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 73/351 (20%), Positives = 134/351 (38%), Gaps = 40/351 (11%) Query: 42 RDPLAFMSQLRDHGDVVRIKLGPKTVYAVTNPELTGALALNPDYHIAGPLWESLEGL--- 98 ++P +F LR + + + VT E T A+ + + + PL ES Sbjct: 13 KNPYSFYDTLRAVHPIYKGSFLKYPGWYVTGYEETAAILKDARFKVRTPLPESSTKYQDL 72 Query: 99 --LGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDATS 156 + + + N P HRR R AF +Y P + E H L ++ Q K ++ S Sbjct: 73 SHVQNQMMLFQNQPDHRRLRTLASGAFTPRTTESYQPYIIETVHHLLDQVQGKKKMEVIS 132 Query: 157 E-SFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRR 215 + +F +A V A + + E+ + +L R + G + + Sbjct: 133 DFAFPLASFVIANIIGVPEEDREQLKEWAASLIQTIDFTRSRKALTEGNIMAV------- 185 Query: 216 FNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPG 275 A+A E+I +R+ Q+ D+++ LL+ ++ D + E+E + + G Sbjct: 186 --QAMA----YFKELIQKRKRHPQQ--DMISMLLKGREK--DKLTEEEAASTCILLAIAG 235 Query: 276 SETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLR 335 ET + I + L HPE ++R+ + + G + E +R Sbjct: 236 HETTVNLISNSVLCLLQHPEQLLKLRENPDLI-----------------GTAVEECLRYE 278 Query: 336 PAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDR 386 + R A + ++ G I G + A RDP + + FD R Sbjct: 279 SPTQMTARVASEDIDICGVTIRQGEQVYLLLGAANRDPSIFTNPDVFDITR 329 >1GWI-A nrPDB Length = 411 Score = 51.2 bits (121), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 63/238 (26%), Positives = 99/238 (41%), Gaps = 33/238 (13%) Query: 225 LLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIM 284 ++ D + A+R A G DDL +AL++A + NGD + + EI + ++ G ET S I+ Sbjct: 197 IMTDTVAAKRAAPG---DDLTSALIQASE-NGDHLTDAEIVSTLQLMVAAGHETTISLIV 252 Query: 285 WLLQALADHPEH-ADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLR-PAVWVLT 342 + L+ HPE A + E E V+ E +R P VL Sbjct: 253 NAVVNLSTHPEQRALVLSGEAE------------------WSAVVEETLRFSTPTSHVLI 294 Query: 343 RRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLE-FDPDRWLPERAANVPKYAMK 401 R A + +G IPAG +I S A+ RD +++ + FD R R + Sbjct: 295 RFAAEDVPVGDRVIPAGDALIVSYGALGRDERAHGPTADRFDLTRTSGNRHIS------- 347 Query: 402 PFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRVGITLRPHDLLVRPV 459 F G CP S + + AL ++ +A +R + +DL PV Sbjct: 348 -FGHGPHVCPGAALSRMEAGVALPALYARFPHLDLAVPAAELRNKPVVTQNDLFELPV 404 >5LIE-A nrPDB Length = 414 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 74/282 (26%), Positives = 116/282 (41%), Gaps = 35/282 (12%) Query: 108 NGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDATSESFRVAVRVAA 167 + P H R RR + I + A L + +PG D E + + Sbjct: 99 DDPRHTRIRRLVSSGLTPRMIRRVEDDLRRRARGLLDGVEPGAPFDFVVE-IAAELPMQM 157 Query: 168 RCLLRGQYMDERAERL-CVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALADLHLL 226 C+L G +R V FRG RR +P RL + DA + L+ Sbjct: 158 ICILLGVPETDRHWLFEAVEPGFDFRGS-RRATMP-----RLNV------EDAGSRLYTY 205 Query: 227 VDEIIAERRASGQKPDDLLTALLEAKDDNGDP--IGEQEIHDQVVAILTPGSETIASTIM 284 E+IA +RA + DD+L+ + A D+ D + + E++ + + G+ET ++I Sbjct: 206 ALELIAGKRA--EPADDMLSVVANATIDDPDAPALSDAELYLFFHLLFSAGAETTRNSIA 263 Query: 285 WLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRR 344 L ALA++P+ +R + E + P A E+ IV P+ R Sbjct: 264 GGLLALAENPDQLQTLRSDFELL----PTAIEE----------IVRWTSPSPSKRRTASR 309 Query: 345 AVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDR 386 AV+ LGG I AG ++ + RDP +D EFD R Sbjct: 310 AVS---LGGQPIEAGQKVVVWEGSANRDPSVFDRADEFDITR 348 >5GWE-A nrPDB Length = 405 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 43/157 (27%), Positives = 73/157 (46%), Gaps = 20/157 (12%) Query: 230 IIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQA 289 ++A+ A G D LTA L G I + EI + ++L G ET + I + Sbjct: 201 MVADAHAHG---GDNLTADLVRAQQEGQEITDHEIASLLYSLLFAGHETTTTLISNCFRV 257 Query: 290 LADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAES 349 L DHPE I + + + P A ++V LR++G+++ W R+A+ ++ Sbjct: 258 LLDHPEQWQAILENPKLI----PAAVDEV--LRYSGSIV---------GW--RRKALKDT 300 Query: 350 ELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDR 386 E+GG I G ++ + RD +++ EFD R Sbjct: 301 EIGGVAIKEGDGVLLLMGSANRDEARFENGEEFDISR 337 >6DCD-A nrPDB Length = 424 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 48/181 (26%), Positives = 76/181 (41%), Gaps = 27/181 (14%) Query: 231 IAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQAL 290 I +RR Q +D+LTAL A +G ++ + G ET A + ++ L Sbjct: 211 IEDRRR--QPRNDVLTALATATYPDGSTPEVIDVVRSATFLFAAGQETTAKLLTAAMRVL 268 Query: 291 ADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESE 350 D P+ R+R+ + N I E++R+ V +R A + Sbjct: 269 GDRPDIQRRLRENRSLIP-----------------NFIEESLRMDSPVKSDSRLARKRTT 311 Query: 351 LGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKC 410 +GG I AG ++ P A RDP+ ++D EF DR NV ++ F+ G C Sbjct: 312 VGGLDIAAGTVVMVLPGAANRDPRRFEDPHEFRLDR------PNVREHMA--FARGVHSC 363 Query: 411 P 411 P Sbjct: 364 P 364 >5XJN-A nrPDB Length = 455 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 43/157 (27%), Positives = 73/157 (46%), Gaps = 20/157 (12%) Query: 230 IIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQA 289 ++A+ A G D LTA L G I + EI + ++L G ET + I + Sbjct: 251 MVADAHAHG---GDNLTADLVRAQQEGQEITDHEIASLLYSLLFAGHETTTTLISNCFRV 307 Query: 290 LADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAES 349 L DHPE I + + + P A ++V LR++G+++ W R+A+ ++ Sbjct: 308 LLDHPEQWQAILENPKLI----PAAVDEV--LRYSGSIV---------GW--RRKALKDT 350 Query: 350 ELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDR 386 E+GG I G ++ + RD +++ EFD R Sbjct: 351 EIGGVAIKEGDGVLLLMGSANRDEARFENGEEFDISR 387 >2VZM-A nrPDB Length = 436 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 44/165 (26%), Positives = 74/165 (44%), Gaps = 18/165 (10%) Query: 219 ALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSET 278 A+A++ + +I +R GQ +DLL+AL+ D++G + +E+ +L G ET Sbjct: 210 AMAEMSGYLSRLIDSKR--GQDGEDLLSALVRTSDEDGSRLTSEELLGMAHILLVAGHET 267 Query: 279 IASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAV 338 + I + AL HP+ +R ++ + G A E++ LR+ G V R Sbjct: 268 TVNLIANGMYALLSHPDQLAALRADMTLLDG----AVEEM--LRYEGPVESATYRF---- 317 Query: 339 WVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFD 383 V +L G IPAG ++ R P+ + D FD Sbjct: 318 ------PVEPVDLDGTVIPAGDTVLVVLADAHRTPERFPDPHRFD 356 >2Y5N-A nrPDB Length = 417 Score = 49.3 bits (116), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 70/288 (24%), Positives = 110/288 (38%), Gaps = 38/288 (13%) Query: 101 KEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQ-PGKTVDATSESF 159 K G+ + + P H R RR + AF + P E AH L ++ G+ D + Sbjct: 100 KGGLLSMDPPEHSRLRRLVVKAFTARRAESLRPRAREIAHELVDQMAATGQPADLVAMFA 159 Query: 160 R-VAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFND 218 R + VRV L +R R A + M + Sbjct: 160 RQLPVRVICELLGVPSADHDRFTRWSGAFLSTAEVTAEEM------------------QE 201 Query: 219 ALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSET 278 A + + ++I RR + DDL++AL++A+D D + EQE+ D + +L G E+ Sbjct: 202 AAEQAYAYMGDLIDRRRK--EPTDDLVSALVQARDQQ-DSLSEQELLDLAIGLLVAGYES 258 Query: 279 IASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAV 338 + I + L PE ++ D E + P A E++ + G Sbjct: 259 TTTQIADFVYLLMTRPELRRQLLDRPELI----PSAVEELTRWVPLG-----------VG 303 Query: 339 WVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDR 386 R AV + L G I AG ++ S A RD + D D DR Sbjct: 304 TAFPRYAVEDVTLRGVTIRAGEPVLASTGAANRDQAQFPDADRIDVDR 351 >4YZR-A nrPDB Length = 405 Score = 48.5 bits (114), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 43/175 (24%), Positives = 82/175 (46%), Gaps = 25/175 (14%) Query: 217 NDALADLHLLVDEIIAERRASGQKP-DDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPG 275 N AL + + ++I +RR KP DDL++ L+ A ++NG + E+E++ + ++ G Sbjct: 187 NQALREFKDYIAKLIHDRRI---KPKDDLISKLVHA-EENGSKLSEKELYSMLFLLVVAG 242 Query: 276 SETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLR 335 ET + + AL H + ++++ + E + A E++ LR+T Sbjct: 243 LETTVNLLGSGTLALLQHKKECEKLKQQPEMIA----TAVEEL--LRYTS---------- 286 Query: 336 PAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDD----NLEFDPDR 386 P V + R A+ + G+ I G I + RDP +++ N+ P+R Sbjct: 287 PVVMMANRWAIEDFTYKGHSIKRGDMIFIGIGSANRDPNFFENPEILNINRSPNR 341 >5D3U-A nrPDB Length = 427 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 74/343 (21%), Positives = 122/343 (35%), Gaps = 46/343 (13%) Query: 101 KEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKT-VDATSESF 159 K V + PLH RR+++ F A Y ++++ AH L G T +DA Sbjct: 105 KNVVMYTDPPLHDALRRSVRAGFTRAAHQHYDQVLQKVAHDLVASIPAGATEIDAVPA-- 162 Query: 160 RVAVRVAARCLLRGQYMDERAERLCV----ALATVFRGMYRRMVVPLGPLYRLPLPANRR 215 +A + R + + E + + T F G + V Sbjct: 163 -LAAELPVRSAVHAFGVPEEDLGFLIPRVNTIMTYFSGPKDQPVT------------QEI 209 Query: 216 FNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPG 275 + L DLH E++ R PD ++ L A+D + EQ +H + + Sbjct: 210 ILEKLTDLHTYASELLQGMRGK-VLPDTVIARLAAAQDGLTETTPEQTVHQLALVFIALF 268 Query: 276 SETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLR 335 + T ++ A A +P +R D + +T N E +R Sbjct: 269 APTTPGSLSSGTLAFARNPRQVERF--------------LADQACVDNTAN---EVLRYN 311 Query: 336 PAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANV 395 + R A + E+GG RI AG + + RD ++ +FD DR P A ++ Sbjct: 312 ASNQFTWRVAAKDVEMGGVRIEAGQTLALFLGSANRDANMFERPNDFDLDR--PNSARHL 369 Query: 396 PKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAG 438 F G C + QL AL ++ + AG Sbjct: 370 ------SFGQGVHACLAAQLISLQLKWFYVALLNRFPGIRTAG 406 >6M7X-A nrPDB Length = 484 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 27/81 (33%), Positives = 40/81 (49%), Gaps = 1/81 (1%) Query: 330 EAMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLP 389 E +RL P L R A ++ L Y IPAG + Y++ R+P + ++P RWL Sbjct: 348 ETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLD 407 Query: 390 ERAANVPKYAMKPFSAGKRKC 410 R + Y + PF G R+C Sbjct: 408 IRGSGRNFYHV-PFGFGMRQC 427 >3R9C-A nrPDB Length = 418 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 61/228 (26%), Positives = 97/228 (42%), Gaps = 34/228 (14%) Query: 223 LHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIAST 282 L L+DE RR G+ DL++ L+ A +++GD + E EI +L G ET + Sbjct: 212 LRALIDE---RRRTPGE---DLMSGLV-AVEESGDQLTEDEIIATCNLLLIAGHETTVNL 264 Query: 283 IMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLT 342 I A+ P + A G R A VI E MR P V +++ Sbjct: 265 IANAALAMLRTPGQWAAL-----AADGSRASA------------VIEETMRYDPPVQLVS 307 Query: 343 RRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKP 402 R A + +G + +P G ++ A RDP + PDR+ P+RA + Sbjct: 308 RYAGDDLTIGTHTVPKGDTMLLLLAAAHRDP-----TIVGAPDRFDPDRA----QIRHLG 358 Query: 403 FSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRVGITLR 450 F G C + + T+ ALA ++ +++G + R +TLR Sbjct: 359 FGKGAHFCLGAPLARLEATVALPALAARFPEARLSGEPEYKR-NLTLR 405 >5VWS-A nrPDB Length = 393 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 73/288 (25%), Positives = 112/288 (38%), Gaps = 32/288 (11%) Query: 99 LGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDATSES 158 GK G+ + P HR QRR I AF +I A P + + A L + PG D E Sbjct: 73 FGKGGITMIDPPEHRHQRRLITHAFTPQSISAMEPRIRQIADHLLDEL-PGPEFDLV-EH 130 Query: 159 FRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFND 218 F + V L G +R +FR R++ Y P A R Sbjct: 131 FAYPLPVIVIAELLGVPPGDRH---------LFRTWSDRLMSLQVENYADPELA-RTVAA 180 Query: 219 ALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSET 278 A+ +++ + E RR + DDLLT L++A+ + G + +E+ + +L G T Sbjct: 181 AMTEMNDYLREHCRSRRTHPR--DDLLTRLVQAEVE-GKRLDLEEVVNTASLLLLAGHLT 237 Query: 279 IASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAV 338 I + L DHPE +R + + P A E E++RLR Sbjct: 238 TTVLIGNTMLCLWDHPEAEKAVRADPSLI----PAALE-------------ESLRLRSPF 280 Query: 339 WVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDR 386 R + + G IPA ++ + D + + D FD R Sbjct: 281 LQAGRVTTRDVTIAGETIPANRFVMAWILSANHDDRRFPDPERFDLHR 328 >2WIO-A nrPDB Length = 431 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 47/172 (27%), Positives = 74/172 (43%), Gaps = 20/172 (11%) Query: 215 RFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTP 274 R D L L + AERRA DDL++ L+ A+ D G + ++E + A+L Sbjct: 205 RIADVLNPLTAYLKARCAERRA--DPGDDLISRLVLAEVD-GRALDDEEAANFSTALLLA 261 Query: 275 GSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRL 334 G T + +++ L +HP H D A ED ++ ++ E +R Sbjct: 262 GHITTTVLLGNIVRTLDEHPAHWD--------------AAAEDPGRI---PAIVEEVLRY 304 Query: 335 RPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDR 386 RP + R +E+ G IPA + + RD ++DD FDP R Sbjct: 305 RPPFPQMQRTTTKATEVAGVPIPADVMVNTWVLSANRDSDAHDDPDRFDPSR 356 >6BLD-A nrPDB Length = 419 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 57/208 (27%), Positives = 87/208 (41%), Gaps = 27/208 (12%) Query: 223 LHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIAST 282 LH + + AERR + DDL +AL+ A+ D GD + + ++ V + G++T T Sbjct: 212 LHQVAASLAAERR--DRPGDDLFSALVNAEVD-GDRLADADVAAFFVLLAVAGNDTTRQT 268 Query: 283 IMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLT 342 I L+AL D P + +A D R G + E +R V Sbjct: 269 ISHGLKALTDFPSQKAWL------------LADFDTR----IGTAVEELVRWATPVMTFR 312 Query: 343 RRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKP 402 R A A+ ELGG I AG ++ YA ++D++ P+R R+ P + Sbjct: 313 RTAAADFELGGQLIRAGEKVVMF-YA----SGNWDEDAFCHPERLDLSRS---PNPHVGF 364 Query: 403 FSAGKRKCPSDHFSMAQLTLITAALATK 430 G C H + AQL I L + Sbjct: 365 GGGGVHFCLGAHLARAQLRAIFGELLVQ 392 >3BUJ-A nrPDB Length = 397 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 48/178 (26%), Positives = 74/178 (41%), Gaps = 28/178 (15%) Query: 242 DDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIR 301 +DLL +L+A D + EI VV + G ET+AS + + +L HP+ D +R Sbjct: 203 EDLLALMLDAHDRG--LMSRNEIVSTVVTFIFTGHETVASQVGNAVLSLLAHPDQLDLLR 260 Query: 302 DEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESELGGYRIPAGAD 361 R+ + E +R P+V TR+ + EL G R+ Sbjct: 261 -----------------RRPDLLAQAVEECLRYDPSVQSNTRQLDVDVELRGRRLRRDDV 303 Query: 362 IIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQ 419 ++ A RDP+ YD +FD +R VP + F AG R C + + Q Sbjct: 304 VVVLAGAANRDPRRYDRPDDFDIER------DPVPSMS---FGAGMRYCLGSYLARTQ 352 >2RCM-A nrPDB Length = 495 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 39/155 (25%), Positives = 70/155 (45%), Gaps = 16/155 (10%) Query: 291 ADHPEHADRIRDEVEAV--TGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRA--- 345 A H H +R+ +E+ +V + G + + K+ T +V+ E +R P V RA Sbjct: 313 AGHQVH-NRLAEEIRSVIKSNGGELTMGAIEKMELTKSVVYECLRFEPPVTAQYGRAKKD 371 Query: 346 -VAESELGGYRIPAGADII-YSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAM--- 400 V ES +++ AG + Y P A RDPK +D EF P+R++ E + ++ + Sbjct: 372 LVIESHDAAFKVKAGEMLYGYQPLA-TRDPKIFDRADEFVPERFVGEEGEKLLRHVLWSN 430 Query: 401 ----KPFSAGKRKCPSDHFSMAQLTLITAALATKY 431 + + G ++C F + L + +Y Sbjct: 431 GPETETPTVGNKQCAGKDFVVLVARLFVIEIFRRY 465 >5FYF-A nrPDB Length = 470 Score = 45.4 bits (106), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 39/199 (19%), Positives = 88/199 (44%), Gaps = 26/199 (13%) Query: 234 RRASGQKPDDLLTALLEAKDDNGDPIGE-QEIHDQVVAILTPGSETIASTIMWLLQALAD 292 RRA+G++P L +LL++ + D I E + ++ G++T +++ L A+ + Sbjct: 266 RRAAGEEPGFDLISLLQSNKETKDLINRPMEFIGNLTLLIVGGNDTTRNSMSGGLVAMNE 325 Query: 293 HPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESELG 352 P ++++ + E + N++ E +R + + + R A + ELG Sbjct: 326 FPREFEKLKAKPELIP-----------------NMVSEIIRWQTPLAYMRRIAKQDVELG 368 Query: 353 GYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPS 412 G I G ++ + RD + +D +PD+++ +R + F G +C Sbjct: 369 GQTIKKGDRVVMWYASGNRDERKFD-----NPDQFIIDRKDARNHMS---FGYGVHRCMG 420 Query: 413 DHFSMAQLTLITAALATKY 431 + + QL ++ + ++ Sbjct: 421 NRLAELQLRILWEEILKRF 439 >2Z36-A nrPDB Length = 413 Score = 45.1 bits (105), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 51/209 (24%), Positives = 83/209 (39%), Gaps = 28/209 (13%) Query: 219 ALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSET 278 A A+L +D++I R + DDL + + + G + + +LT G ET Sbjct: 193 AFAELRAYIDDLIT--RKESEPGDDLFSRQIARQRQEG-TLDHAGLVSLAFLLLTAGHET 249 Query: 279 IASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAV 338 A+ I + L HPE ++ A G P+A E++ LR+ A Sbjct: 250 TANMISLGVVGLLSHPEQLTVVK----ANPGRTPMAVEEL--LRY----------FTIAD 293 Query: 339 WVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKY 398 V +R A + E+GG I AG +I S + DP + D D +R A Sbjct: 294 GVTSRLATEDVEIGGVSIKAGEGVIVSMLSANWDPAVFKDPAVLDVERGARHHLA----- 348 Query: 399 AMKPFSAGKRKCPSDHFSMAQLTLITAAL 427 F G +C + + +L ++ L Sbjct: 349 ----FGFGPHQCLGQNLARMELQIVFDTL 373 >5L94-A nrPDB Length = 410 Score = 45.1 bits (105), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 41/158 (25%), Positives = 72/158 (45%), Gaps = 22/158 (13%) Query: 230 IIAERRASGQKP-DDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQ 288 II E+R +P DD+++ LL+AK++ G + ++EI + +L G+ET + I + Sbjct: 201 IIEEKRT---RPGDDIISVLLQAKEE-GKQLTDEEIVGFSILLLIAGNETTTNLISNTIY 256 Query: 289 ALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAE 348 L + +R++ E E + G I E +R R V L R + Sbjct: 257 CLMEDKASFERLKREKELLPSG-----------------IEEVLRYRSPVQALHRIVKED 299 Query: 349 SELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDR 386 L G ++ AG ++ + RD + ++D F DR Sbjct: 300 VTLAGKKLKAGEHVVPWMGSAHRDAEYFEDPEVFKIDR 337 >4PWV-A nrPDB Length = 446 Score = 45.1 bits (105), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 42/165 (25%), Positives = 73/165 (44%), Gaps = 20/165 (12%) Query: 222 DLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIAS 281 ++ L E++AERRA KP + + ++L +G P+ E+ I +++ G ET Sbjct: 221 EILLYFSELVAERRA---KPTEDVISVLANSMVDGKPLTEEVIVLNCYSLILGGDETSRL 277 Query: 282 TIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVL 341 +++ +Q +P+ + +RD G+ V E + E +R Sbjct: 278 SMIDSVQTFTQYPDQWELLRD-------GK-VTLESATE---------EVLRWATPAMHF 320 Query: 342 TRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDR 386 RRAV + EL G I AG + + RD + + D FD +R Sbjct: 321 GRRAVTDMELHGQVIAAGDVVTLWNNSANRDEEVFADPYAFDLNR 365 >3MGX-A nrPDB Length = 415 Score = 44.7 bits (104), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 54/213 (25%), Positives = 85/213 (39%), Gaps = 35/213 (16%) Query: 219 ALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSET 278 A ++ + DE+I RR ++P D L + L DD + ++ +L G+ET Sbjct: 206 AHTEILVYFDELITARR---KEPGDDLVSTLVTDDD----LTIDDVLLNCDNVLIGGNET 258 Query: 279 IASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMR-LRPA 337 I + ALA P +RD V V+ E +R PA Sbjct: 259 TRHAITGAVHALATVPGLLTALRDGSADVD-----------------TVVEEVLRWTSPA 301 Query: 338 VWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPK 397 + VL R A+ + G +P+G ++ A RDP +D DPD +LP R N Sbjct: 302 MHVL-RVTTADVTINGRDLPSGTPVVAWLPAANRDPAEFD-----DPDTFLPGRKPN--- 352 Query: 398 YAMKPFSAGKRKCPSDHFSMAQLTLITAALATK 430 F G C + +L+++ LA + Sbjct: 353 -RHITFGHGMHHCLGSALARIELSVVLRVLAER 384 >3NC3-A nrPDB Length = 441 Score = 44.7 bits (104), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 78/399 (19%), Positives = 161/399 (40%), Gaps = 42/399 (10%) Query: 39 RLARDPLAFMSQLRDHGDVVRIKLGPKTVYAVTNPELTGALALNPDYHIAGPLWESLEGL 98 + +P A+ SQLR+ D V + + Y ++ + +PD L E E + Sbjct: 50 QFQNNPYAYFSQLREE-DPVHYEESIDS-YFISRYHDVRYILQHPDIFTTKSLVERAEPV 107 Query: 99 LGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERW-QPGKT--VDAT 155 + +A +G H +RR + +F DA+ P++++ A L + + GK+ V+ Sbjct: 108 MRGPVLAQMHGKEHSAKRRIVVRSFIGDALDHLSPLIKQNAENLLAPYLERGKSDLVNDF 167 Query: 156 SESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRR 215 ++F V V + L + + E+ +A + + P R Sbjct: 168 GKTFAVCVTMDMLGLDKRDH--EKISEWHSGVADFITSISQS-------------PEARA 212 Query: 216 FNDALAD-LHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTP 274 + ++ L + +I ERR + P L ++L + G + +++I ++ +L Sbjct: 213 HSLWCSEQLSQYLMPVIKERRVN---PGSDLISILCTSEYEGMALSDKDILALILNVLLA 269 Query: 275 GSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRL 334 +E T+ ++ L ++PE + + + V P A I E +R Sbjct: 270 ATEPADKTLALMIYHLLNNPEQMNDVLADRSLV----PRA-------------IAETLRY 312 Query: 335 RPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRW-LPERAA 393 +P V ++ R+ ++ +GG I + A RDP++++ F+ R L ++A Sbjct: 313 KPPVQLIPRQLSQDTVVGGMEIKKDTIVFCMIGAANRDPEAFEQPDVFNIHREDLGIKSA 372 Query: 394 NVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYR 432 F +G C F+ ++ ++ + K R Sbjct: 373 FSGAARHLAFGSGIHNCVGTAFAKNEIEIVANIVLDKMR 411 >6GK6-A nrPDB Length = 411 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 40/146 (27%), Positives = 61/146 (41%), Gaps = 19/146 (13%) Query: 242 DDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIR 301 DDL++ LL A++ + E+ V +L G ET I + L HP R+ Sbjct: 212 DDLISGLLLAEEQEHK-LSPAELSSMVFLLLVAGHETTVHLIASGMLLLLSHPAERRRLD 270 Query: 302 DEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLR-PAVWVLTRRAVAESELGGYRIPAGA 360 ++ V G+ + EA+R PA R ++ + EL G R+PAG Sbjct: 271 EDPGLV-----------------GSAVEEALRCEGPAELSTIRWSLEDIELFGARVPAGE 313 Query: 361 DIIYSPYAIQRDPKSYDDNLEFDPDR 386 + A RDP+ + D FD R Sbjct: 314 GVAAGLLAANRDPQHFPDPDRFDIGR 339 >5YHJ-A nrPDB Length = 413 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 74/344 (21%), Positives = 130/344 (37%), Gaps = 41/344 (11%) Query: 95 LEGLLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDA 154 L+ L G+ GV T +G H +++ + I + E + + + D Sbjct: 75 LKTLFGEGGVQTLDGSEHTHRKQMFMSLMTKENIDRLLRLTYREWNQIERMGEEIVLYDI 134 Query: 155 TSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANR 214 E AV + L + + +R E + + + LGP Y L + Sbjct: 135 AQEVLMKAVCEWSGVPLAKEEVGKRTEEMRLLFESG---------TSLGPTY---LQGRK 182 Query: 215 RFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEA---KDDNGDPIGEQEIHDQVVAI 271 A + + + +++ E R++ P++ TAL E +D++G+ + E+ + +V+ I Sbjct: 183 ----ARSSAEVWIRQMVKEVRSNRLLPNEH-TALYEFSWHRDESGELLPEEVVAVEVLNI 237 Query: 272 LTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEA 331 L P T+A ++ L LA H + D E V G E V+++R Sbjct: 238 LRP---TVAISVYVLFTVLALH-----QFPDVKEQVERGEVSKTEFVQEVR--------- 280 Query: 332 MRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRW--LP 389 R P V R + E GY P G + Y D + + FDP R+ Sbjct: 281 -RFYPFFPVAAARVKTDFEWDGYAFPEGTLTLLDLYGTNHDVSIWTEPDRFDPSRFKDWK 339 Query: 390 ERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRF 433 E N G R C +H ++A L + +Y + Sbjct: 340 ESPFNFIPQGGGDVDFGHR-CAGEHVTIAILAQVIELFTKEYAY 382 >2WIY-A nrPDB Length = 394 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 37/122 (30%), Positives = 52/122 (42%), Gaps = 8/122 (6%) Query: 311 RPVAFEDVRKLRHT-GNVIVEAMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAI 369 RP F R +I E +R+ P R + E+GG I AG+ I + A Sbjct: 252 RPEVFTAFRNDESARAAIINEMVRMDPPQLSFLRFPTEDVEIGGVLIEAGSPIRFMIGAA 311 Query: 370 QRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALAT 429 RDP+ +DD FD R P A+ + + P S C S A+ T + A LA Sbjct: 312 NRDPEVFDDPDVFDHTR--PPAASRNLSFGLGPHS-----CAGQIISRAEATTVFAVLAE 364 Query: 430 KY 431 +Y Sbjct: 365 RY 366 >4MM0-A nrPDB Length = 399 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 71/291 (24%), Positives = 115/291 (39%), Gaps = 47/291 (16%) Query: 102 EGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDATSESFRV 161 E V T + P+H R RR + F I P +EE A L + + ES V Sbjct: 83 ESVMTTDPPVHTRLRRLLSRDFTARRIERMRPRLEEIAEGLLDEMEKKGAPADIVESLAV 142 Query: 162 AVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALA 221 + C L G M + A FRG MV G Y + + A Sbjct: 143 PFPITVICELLGVPMVDVAR---------FRGWADTMVSLTG--YSM-----EDWTAARD 186 Query: 222 DLHLLVDEIIAERRASGQKP-DDLLTALL-EAKDDNGDPIGEQEIHDQVVAIL----TPG 275 L +D ++A +R + P DLL+AL+ A +DN + + ++ + +L P Sbjct: 187 ALESYLDGLVAAKR---ENPGSDLLSALVATAAEDN--ELTDHDVRSLSLILLLAGYEPA 241 Query: 276 SETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLR 335 S + S+++ LL+ P+ +R + G P A E++ + G+ Sbjct: 242 SNQLGSSVLTLLR----FPDRLAELRRD----PGLLPSAVEELMRYAPAGD--------- 284 Query: 336 PAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDR 386 L R + + +G IPA + ++ S A DP+ +DD DR Sbjct: 285 ---GALFRVTLEDVTIGDTHIPANSAVLASTQAANWDPRRFDDPTGLRLDR 332 >2WM5-A nrPDB Length = 435 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 42/168 (25%), Positives = 73/168 (43%), Gaps = 19/168 (11%) Query: 216 FNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPG 275 F AD+ + +RR + DDL ++L+EA+ D G+ + +EI + ++ G Sbjct: 219 FMQVSADIGAYATALAEDRRVNHH--DDLTSSLVEAEVD-GERLSSREIASFFILLVVAG 275 Query: 276 SETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLR 335 +ET + I + AL+ +PE DR + + G P A E++ +R Sbjct: 276 NETTRNAITHGVLALSRYPEQRDRWWSDFD---GLAPTAVEEI-------------VRWA 319 Query: 336 PAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFD 383 V + R + EL G ++ AG + + RD + D FD Sbjct: 320 SPVVYMRRTLTQDIELRGTKMAAGDKVSLWYCSANRDESKFADPWTFD 367 >4TRI-A nrPDB Length = 407 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 47/213 (22%), Positives = 89/213 (41%), Gaps = 29/213 (13%) Query: 212 ANRRFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAI 271 A ++ D A ++I +RRA + DDL + L+ ++ + G + + EI + + I Sbjct: 174 AIQKLMDTFAAYTEFTKDVITKRRA--EPTDDLFSVLVNSEVE-GQRMSDDEIVFETLLI 230 Query: 272 LTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEA 331 L G ET T+ + L H + D + +V+ + G I E Sbjct: 231 LIGGDETTRHTLSGGTEQLLRHRDQWDALVADVDLLPGA-----------------IEEM 273 Query: 332 MRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPER 391 +R V + R A++ G + AG I+ + + ++D+++ DPD + +R Sbjct: 274 LRWTSPVKNMCRTLTADTVFHGTELRAGEKIM-----LMFESANFDESVFGDPDNFRIDR 328 Query: 392 AANVPKYAMKPFSAGKRKCPSDHFSMAQLTLIT 424 N + F G C + + +L L+T Sbjct: 329 NPN----SHVAFGFGTHFCLGNQLARLELRLMT 357 >5DE9-A nrPDB Length = 410 Score = 43.1 bits (100), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 45/161 (27%), Positives = 69/161 (42%), Gaps = 26/161 (16%) Query: 268 VVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFED-VRKLRHTGN 326 + +L G E + + + L PE A+R+R E E RP A ++ +R + H Sbjct: 235 LAVLLQIGGEAVTNNSGQMFHLLLSRPELAERLRSEPEI----RPRAIDELLRWIPHRNA 290 Query: 327 VIVEAMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDR 386 V L+R A+ + E+ G RI AG + S A RDP+ + DPDR Sbjct: 291 V------------GLSRIALEDVEIKGVRIRAGDAVYVSYLAANRDPEVFP-----DPDR 333 Query: 387 WLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAAL 427 ER+ N P + F G CP + + L+ A+ Sbjct: 334 IDFERSPN-PHVS---FGFGPHYCPGGMLARLESELLVDAV 370 >3IVY-A nrPDB Length = 433 Score = 42.7 bits (99), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 39/153 (25%), Positives = 66/153 (43%), Gaps = 21/153 (13%) Query: 231 IAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQAL 290 +AE +A DD++T L++A D +G+ + + E VV + G+ET ++I + A Sbjct: 227 MAEEKAK-NPADDIVTQLIQA-DIDGEKLSDDEFGFFVVMLAVAGNETTRNSITQGMMAF 284 Query: 291 ADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESE 350 A+HP D+ E RP D E +R V R A+ + E Sbjct: 285 AEHP-------DQWELYKKVRPETAAD------------EIVRWATPVTAFQRTALRDYE 325 Query: 351 LGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFD 383 L G +I G ++ + D + + D F+ Sbjct: 326 LSGVQIKKGQRVVMFYRSANFDEEVFQDPFTFN 358 >4ZGX-A nrPDB Length = 489 Score = 42.7 bits (99), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 40/144 (27%), Positives = 64/144 (44%), Gaps = 9/144 (6%) Query: 272 LTPGS-ETIASTIMWLLQALADHPEHADRIRDEVEA----VTGGRPVAFEDVRKLRHTGN 326 LT GS +T A ++ L LA +P+ +R E A ++ A ++ LR Sbjct: 288 LTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLR---A 344 Query: 327 VIVEAMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDR 386 + E +RL P L R ++ L Y IPAG + Y++ R+ + ++P R Sbjct: 345 ALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQR 404 Query: 387 WLPERAANVPKYAMKPFSAGKRKC 410 WL R + + PF G R+C Sbjct: 405 WLDIRGSG-RNFHHVPFGFGMRQC 427 >3TKT-A nrPDB Length = 450 Score = 42.7 bits (99), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 49/220 (22%), Positives = 92/220 (41%), Gaps = 29/220 (13%) Query: 219 ALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSET 278 A+A+ + AERR + DD+ T + A D G+P+ +++ + + G +T Sbjct: 237 AVAEFERYFAGLAAERRRN--PTDDVATVIANAVVD-GEPMSDRDTAGYYIITASAGHDT 293 Query: 279 IASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAV 338 +++ ALA P+ R++ + + G ++ EA+R V Sbjct: 294 TSASSAGAALALARDPDLFARVKADRNLLPG-----------------IVEEAIRWTTPV 336 Query: 339 WVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKY 398 R A ++EL G +I AG ++ + A DP + + +FDP R P Sbjct: 337 QHFMRTAATDTELCGQKIAAGDWLMLNYVAANHDPAQFPEPRKFDPTR---------PAN 387 Query: 399 AMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAG 438 F AG +C H + ++ ++ L + ++AG Sbjct: 388 RHLAFGAGSHQCLGLHLARLEMRVLLDVLLDRVDSLELAG 427 >5IT1-A nrPDB Length = 399 Score = 42.7 bits (99), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 53/230 (23%), Positives = 92/230 (40%), Gaps = 37/230 (16%) Query: 226 LVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMW 285 L+ +++ ERRA+ DDL++AL+ +D +G I + + + +L +T A I Sbjct: 192 LLYQLVQERRAN--PGDDLISALITTEDPDG-VIDDMFLMNAAGTLLIAAHDTTACMIGL 248 Query: 286 LLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMR-LRPAVWVLTRR 344 L D P+ ++ + + GN + E +R L + R Sbjct: 249 GTALLLDRPDQLALLQKDPSLI-----------------GNAVEELLRYLTIGQFGAERV 291 Query: 345 AVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFS 404 A + E+GG RI G ++ + DP +D FD R R A P A F Sbjct: 292 ATQDGEIGGVRIAKGEQVVTHLLSADFDPAFVEDPERFDITR----RPA--PHLA---FG 342 Query: 405 AGKRKCPSDHFSMAQLTLITAALATKY-------RFEQVAGSNDAVRVGI 447 G +C + +L ++ L ++ E++ ND V G+ Sbjct: 343 FGAHQCIGQQLARIELQIVFGTLFRRFPTLRLAKPVEELRFRNDMVFYGV 392 >6GMF-A nrPDB Length = 397 Score = 42.7 bits (99), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 38/144 (26%), Positives = 61/144 (42%), Gaps = 18/144 (12%) Query: 243 DLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRD 302 DL++ LL A+ D G+ + E+ +L G+ET S I L AL DHPE + Sbjct: 203 DLISQLLAAEVD-GEKLTAGEVLSFANTLLIAGNETTTSLIGNALVALTDHPEQLAAAQA 261 Query: 303 EVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESELGGYRIPAGADI 362 ++ V V+ E +R + R+ + + E+G RIPA + + Sbjct: 262 DLSLVPA-----------------VVEEVLRYESPAQCIFRQTMTDVEIGDERIPARSVV 304 Query: 363 IYSPYAIQRDPKSYDDNLEFDPDR 386 + + RD + D FD R Sbjct: 305 LPLLASANRDESRFPDPDRFDIHR 328 >4UBS-A nrPDB Length = 393 Score = 42.7 bits (99), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 75/332 (22%), Positives = 116/332 (34%), Gaps = 54/332 (16%) Query: 108 NGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDATSESFRVAVRVAA 167 + P HR QRR + P+F L A P ++E L + + +F + + Sbjct: 87 DDPEHRTQRRMLVPSFTLKRAAALRPRIQETVDGLLDAMEAQGPPAELVSAFALPLPSMV 146 Query: 168 RCLLRGQ-YMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALADLHLL 226 C L G Y D F RR+ L P DA A L Sbjct: 147 ICALLGVPYADH----------DFFESQSRRL---------LRGPGIAEVQDARAQLDDY 187 Query: 227 VDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWL 286 + +I +R + D LL L++ + + G + E+ +L G ET A+ I Sbjct: 188 LYALIDRKRK--EPGDGLLDDLIQEQLNRGT-VDRAELVSLATLLLIAGHETTANMISLG 244 Query: 287 LQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAV 346 L HPE +R E G P A E E +R L R A Sbjct: 245 TFTLLRHPEQLAELRAE----PGLMPAAVE-------------ELLRFLSIADGLLRVAT 287 Query: 347 AESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAG 406 + E+ G I A ++++ I RD + + D R A F G Sbjct: 288 EDIEVAGTTIRADEGVVFATSVINRDAAGFAEPDALDWHRSARHHVA---------FGFG 338 Query: 407 KRKCPSDHFSMAQLTLITAALATKYRFEQVAG 438 +C + + A++ + L FE++ G Sbjct: 339 IHQCLGQNLARAEMEIALGTL-----FERLPG 365 >2ZBZ-A nrPDB Length = 412 Score = 42.7 bits (99), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 82/320 (25%), Positives = 121/320 (37%), Gaps = 50/320 (15%) Query: 110 PLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHA-LTERWQPGKTVDATSESFRVAVRVAAR 168 P H +RR F + I P +EE H L E G T D S+ F + V Sbjct: 101 PEHGTRRRMTISEFTVKRIKGMRPEVEEVVHGFLDEMLAAGPTADLVSQ-FALPVPSMVI 159 Query: 169 CLLRGQ-YMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALADLHLLV 227 C L G Y D F+ +R+V L ND L L+ Sbjct: 160 CRLLGVPYADHE----------FFQDASKRLVQSTDAQSAL-----TARNDLAGYLDGLI 204 Query: 228 DEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLL 287 + E A L+ AL+ + NG+ I +E+ + +L G ET AS + Sbjct: 205 TQFQTEPGAG------LVGALVADQLANGE-IDREELISTAMLLLIAGHETTASMTSLSV 257 Query: 288 QALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVA 347 L DHPE +R + V G A E++ LR+ + R+ A A Sbjct: 258 ITLLDHPEQYAALRADRSLVPG----AVEEL--LRYLAIADIAGGRV----------ATA 301 Query: 348 ESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGK 407 + E+ G I AG +I RD Y+ DPD R+A ++ + F G Sbjct: 302 DIEVEGQLIRAGEGVIVVNSIANRDGTVYE-----DPDALDIHRSA---RHHLA-FGFGV 352 Query: 408 RKCPSDHFSMAQLTLITAAL 427 +C + + +L +I AL Sbjct: 353 HQCLGQNLARLELEVILNAL 372 >5FOI-A nrPDB Length = 408 Score = 42.4 bits (98), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 43/187 (22%), Positives = 71/187 (37%), Gaps = 26/187 (13%) Query: 259 IGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDV 318 I QE+ + V +L G ET A+ + + L HPE A +R++ E + Sbjct: 232 ITHQELVNNAVLLLAAGHETSANQVTLSVLTLLRHPETAAELREQPELMP---------- 281 Query: 319 RKLRHTGNVIVEAMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDD 378 N + E +R L R A A+ LG + I AG +I + D ++ Sbjct: 282 -------NAVDELLRYHSIADGLRRAATADIVLGDHTIRAGDGLIILLSSANHDGNTFGA 334 Query: 379 NLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAG 438 FD R P F G +C + + ++ + L + ++A Sbjct: 335 EATFDIHR---------PARHHVAFGYGPHQCLGQNLARLEMEVTLGKLFRRVPALRLAQ 385 Query: 439 SNDAVRV 445 DA+RV Sbjct: 386 EPDALRV 392 >5DQN-A nrPDB Length = 426 Score = 42.4 bits (98), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 40/153 (26%), Positives = 69/153 (45%), Gaps = 21/153 (13%) Query: 231 IAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQAL 290 +AE RA +D++T L+EA D +G+ + + E VV + G+ET ++I + A Sbjct: 210 MAEERAVNPT-EDIVTKLIEA-DIDGEKLSDDEFGFFVVMLAVAGNETTRNSITHGMIAF 267 Query: 291 ADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESE 350 A +P+ + + E RP D E +R V R A+ + E Sbjct: 268 AQNPDQWELYKKE-------RPETAAD------------EIVRWATPVSAFQRTALEDVE 308 Query: 351 LGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFD 383 LGG +I G ++ S + D + ++D F+ Sbjct: 309 LGGVQIKKGQRVVMSYRSANFDEEVFEDPHTFN 341 >1EHE-A nrPDB Length = 403 Score = 42.0 bits (97), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 49/221 (22%), Positives = 96/221 (43%), Gaps = 35/221 (15%) Query: 212 ANRRFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAI 271 AN+ D LA +LV++ + E + DD+++ L + G+ I + + + Sbjct: 187 ANQELLDYLA---ILVEQRLVEPK------DDIISKLCTEQVKPGN-IDKSDAVQIAFLL 236 Query: 272 LTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEA 331 L G+ T+ + I + LA HP+ +++ A P E++ + HT + + Sbjct: 237 LVAGNATMVNMIALGVATLAQHPDQLAQLK----ANPSLAPQFVEELCRY-HTASALA-- 289 Query: 332 MRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDR-WLPE 390 + R A + +G + A II S + RD + +++ EF+ +R W P+ Sbjct: 290 ---------IKRTAKEDVMIGDKLVRANEGIIASNQSANRDEEVFENPDEFNMNRKWPPQ 340 Query: 391 RAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKY 431 F G +C ++H + A+LT + + L K+ Sbjct: 341 DPLG--------FGFGDHRCIAEHLAKAELTTVFSTLYQKF 373 >3DBM-A nrPDB Length = 473 Score = 42.0 bits (97), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 40/153 (26%), Positives = 76/153 (49%), Gaps = 13/153 (8%) Query: 246 TALLEAKDDNGDPIGEQEIHDQVVAIL--TPGSETIA--STIMWL-LQALADHPEHADRI 300 T ++E + G P ++ +H+ + A+ T G I +T+ W+ L H + A+ I Sbjct: 249 TPVMEQAEKLGVP-KDEAVHNILFAVCFNTFGGVKILFPNTLKWIGLAGENLHTQLAEEI 307 Query: 301 RDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVA----ESELGGYRI 356 R +++ G V E + ++ T +V+ E++R+ P V +A + ES + + Sbjct: 308 RGAIKSYGDGN-VTLEAIEQMPLTKSVVYESLRIEPPVPPQYGKAKSNFTIESHDATFEV 366 Query: 357 PAGADII-YSPYAIQRDPKSYDDNLEFDPDRWL 388 G + Y P+A +DPK +D E+ PDR++ Sbjct: 367 KKGEMLFGYQPFAT-KDPKVFDRPEEYVPDRFV 398 >6FYJ-A nrPDB Length = 421 Score = 42.0 bits (97), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 61/313 (19%), Positives = 115/313 (36%), Gaps = 42/313 (13%) Query: 95 LEGLLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDA 154 ++ L GK GV +G H+ ++ D + I +++ ++W+ V Sbjct: 79 VQTLFGKNGVQALDGQTHKHRKEMFMSIMSPDELEKLTDITKKQWEIAVDKWEQMDKVIL 138 Query: 155 TSESFRVAVRVAARCLLRGQYMDER-AERLCVALATVFRGMYRRMVVPLGPLYRLPLPAN 213 E+ + R A C G + E +RL L +F +G + L A Sbjct: 139 YEEAKEIMCRTA--CQWAGVPVQENEVKRLTKNLGAMFES-----AAAVGLKHWLGRHA- 190 Query: 214 RRFNDALADLHLLVDEIIAERRASGQKP--DDLLTALLEAKDDNGDPIGEQEIHDQVVAI 271 R + + + ++E+I R P + L +D G+ + + +V+ I Sbjct: 191 RNYEE------IWIEELIDRVRDGKVNPPENTTLHKFSWYRDLEGNLLDTETAAVEVINI 244 Query: 272 LTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEA 331 L P IA I ++ AL +PE ++++ +G + +++ + E Sbjct: 245 LRPIV-AIAIFINFIALALHHYPEEKEKLK------SGDK----------KYSQMFVQEV 287 Query: 332 MRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPER 391 R P + + GY+ G + Y DP+ + + F PDR Sbjct: 288 RRFYPFFPFVVALVKKDFTWKGYKFEEGTLTLLDLYGTNHDPEIWKNPDVFSPDR----- 342 Query: 392 AANVPKYAMKPFS 404 K+ PFS Sbjct: 343 ---FAKWEGSPFS 352 >4GGV-A nrPDB Length = 418 Score = 42.0 bits (97), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 48/172 (27%), Positives = 75/172 (43%), Gaps = 23/172 (13%) Query: 218 DALADLHLLVDEI---IAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTP 274 DA L L+D + + ERR + ++ DLLT L++A+ D G+ + + EI + +L Sbjct: 201 DATERLRPLLDYMAGHVTERRRTPRE--DLLTHLVQAEVD-GERLTDNEIVNVANILLVT 257 Query: 275 GSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRL 334 G T T+ + L PE A ++R + V G I EA+R+ Sbjct: 258 GHITTTMTLGNTVLCLDADPEVAAKVRADRSLVPGA-----------------IEEALRV 300 Query: 335 RPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDR 386 L R E E+ G IP ++ A RDP+ + D +DP R Sbjct: 301 LSPSAALARGTSREVEVAGTVIPKDQIVMLWLGAGNRDPRQFTDPEVYDPTR 352 >3A1L-A nrPDB Length = 425 Score = 42.0 bits (97), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 37/125 (29%), Positives = 52/125 (41%), Gaps = 17/125 (13%) Query: 254 DNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPV 313 D G P+ I V +LT G ET T +L +A+ H D + DE+ P Sbjct: 234 DTGSPLSVDGIVGTCVHLLTAGHET---TTNFLAKAVLTLRAHRD-VLDELRTTPESTPA 289 Query: 314 AFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDP 373 A E E MR P V +TR A + LG + IP G+ ++ + RDP Sbjct: 290 AVE-------------ELMRYDPPVQAVTRWAYEDIRLGDHDIPRGSRVVALLGSANRDP 336 Query: 374 KSYDD 378 + D Sbjct: 337 ARFPD 341 >2IAG-A nrPDB Length = 482 Score = 42.0 bits (97), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 20/69 (28%), Positives = 38/69 (55%), Gaps = 5/69 (7%) Query: 23 EPPVAGGGVPLLGHGWRLARDPLAFMSQLRD-HGDVVRIKLGPKTVYAVTNPELTGALAL 81 EPP+ G +P LG+ +D +F++++++ HGD+ I +G + V + +P A+ Sbjct: 7 EPPLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTVLLDPHSYDAVVW 66 Query: 82 NP----DYH 86 P D+H Sbjct: 67 EPRTRLDFH 75 >2FR7-A nrPDB Length = 412 Score = 41.2 bits (95), Expect = 9e-04, Method: Compositional matrix adjust. Identities = 46/192 (23%), Positives = 74/192 (38%), Gaps = 27/192 (14%) Query: 247 ALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEA 306 A + A D G+ I +E V ++L+ G +T + I + LA P+ R+R + Sbjct: 225 ACIHAFSDTGE-ITPEEAPLLVRSLLSAGLDTTVNGIAAAVYCLARFPDEFARLRADPSL 283 Query: 307 VTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSP 366 N EA+R V R + EL G I G ++ Sbjct: 284 AR-----------------NAFEEAVRFESPVQTFFRTTTRDVELAGATIGEGEKVLMFL 326 Query: 367 YAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAA 426 + RDP+ +D DPDR+ R + F +G C + + ++ AA Sbjct: 327 GSANRDPRRWD-----DPDRYDITRKTS----GHVGFGSGVHMCVGQLVARLEGEVVLAA 377 Query: 427 LATKYRFEQVAG 438 LA K ++AG Sbjct: 378 LARKVAAIEIAG 389 >3RWL-A nrPDB Length = 426 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 47/230 (20%), Positives = 96/230 (41%), Gaps = 29/230 (12%) Query: 229 EIIAERRASGQKPDDLLTALLEA-KDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLL 287 +++ R + +DL++ L + N P +E V+ ++ G++T +++ + Sbjct: 222 QVLWNERVNKDPGNDLISMLAHSPATRNMTP---EEYLGNVLLLIVGGNDTTRNSMTGGV 278 Query: 288 QALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVA 347 AL +P+ +++ P E ++ E +R + + + R A+A Sbjct: 279 LALHKNPDQFAKLK--------ANPALVE---------TMVPEIIRWQTPLAHMRRTAIA 321 Query: 348 ESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGK 407 +SELGG I G ++ Y+ RD + D EF DR P + + F G Sbjct: 322 DSELGGKTIRKGDKVVMWYYSGNRDDEVIDRPEEFIIDRPRPRQHLS--------FGFGI 373 Query: 408 RKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRVGITLRPHDLLVR 457 +C + + QL ++ + T++ +V + VR ++VR Sbjct: 374 HRCVGNRLAEMQLRILWEEILTRFSRIEVMAEPERVRSNFVRGYAKMMVR 423 >1UED-A nrPDB Length = 406 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 99/395 (25%), Positives = 151/395 (38%), Gaps = 79/395 (20%) Query: 18 APELREPPVAGGGVPLLGHGWRLARDPLAFMSQLRDHGDVVRI------KLGPKTVYAVT 71 AP LREP R DP LR HG +VRI +LG V+ Sbjct: 9 APLLREPA---------NFQLRTNCDPHEDNFGLRAHGPLVRIVGESSTQLGRDFVWQAH 59 Query: 72 NPELTGALALNPDYHIAGPLW-ESLEG------LLGKEGVATANGPLHRRQRRTIQPAFR 124 E+ + + ++ P + +S G +G+ ++T + P H R R+ + P F Sbjct: 60 GYEVVRRILGDHEHFTTRPQFTQSKSGAHVEAQFVGQ--ISTYDPPEHTRLRKMLTPEFT 117 Query: 125 LDAI----PAYGPIMEEEAHALTERWQPGKTVDATSESFRVAVRVAARCLLRGQYMDERA 180 + I PA ++++ L G + D F V A C L G D++ Sbjct: 118 VRRIRRMEPAIQSLIDDRLDLLEAE---GPSADLQG-LFADPVGAHALCELLGIPRDDQR 173 Query: 181 E--RLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALADLHLLVDEIIAERRASG 238 E R A + RG+ R + FN L D ++A +RA Sbjct: 174 EFVRRIRRNADLSRGLKARAA------------DSAAFNRYL-------DNLLARQRAD- 213 Query: 239 QKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHAD 298 PDD L ++ D+GD + ++E+ A++ G ET+A I + + AL D+P Sbjct: 214 --PDDGLLGMIVR--DHGDNVTDEELKGLCTALILGGVETVAGMIGFGVLALLDNP---- 265 Query: 299 RIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESELGGYRIPA 358 G + FE K N +V L P R A+ + + G I A Sbjct: 266 ----------GQIELLFESPEKAERVVNELVRY--LSPVQAPNPRLAIKDVVIDGQLIKA 313 Query: 359 GADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAA 393 G ++ S R D+ L DPD RAA Sbjct: 314 GDYVLCSILMANR-----DEALTPDPDVLDANRAA 343 >5NWS-A nrPDB Length = 435 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 44/165 (26%), Positives = 71/165 (43%), Gaps = 18/165 (10%) Query: 230 IIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQA 289 +I +RRA+ DDLL+ L+ A+DD+G + + E ++ ++ G ET A I A Sbjct: 225 LIEQRRAA--LTDDLLSELIRAQDDDGGRLSDIETVTMILTLVLAGHETSAHLIGNGTAA 282 Query: 290 LADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAES 349 L HP +R + + P A ++ +R G+V V +R A + Sbjct: 283 LLTHPGQWALLRKDPALL----PRAVHEL--MRWCGSVHVARLRY----------ATEDL 326 Query: 350 ELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAAN 394 EL G + G + + DP+ Y D D R +A N Sbjct: 327 ELAGTPVARGDAVQLVLVSANFDPRHYSDPDRLDITRHQEGQAEN 371 >4RM4-A nrPDB Length = 396 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 42/158 (26%), Positives = 73/158 (46%), Gaps = 22/158 (13%) Query: 230 IIAERRASGQKPD-DLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQ 288 II E+R KP+ D+++ L+EA ++ G+ + +E+ +L G+ET + I + Sbjct: 198 IIEEKR---NKPEQDIISILVEA-EETGEKLSGEELIPFCTLLLVAGNETTTNLISNAMY 253 Query: 289 ALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAE 348 ++ + P + +R E + P A E EA+R R VL R A + Sbjct: 254 SILETPGVYEELRSHPELM----PQAVE-------------EALRFRAPAPVLRRIAKRD 296 Query: 349 SELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDR 386 +E+GG+ I G ++ + RD +D FD R Sbjct: 297 TEIGGHLIKEGDMVLAFVASANRDEAKFDRPHMFDIRR 334 >3ABA-A nrPDB Length = 403 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 50/203 (24%), Positives = 83/203 (40%), Gaps = 30/203 (14%) Query: 226 LVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMW 285 L+ +++ ERRA+ DDL++AL+ +D +G + + + + +L +T A I Sbjct: 192 LLYQLVQERRAN--PGDDLISALITTEDPDG-VVDDMFLMNAAGTLLIAAHDTTACMIGL 248 Query: 286 LLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMR-LRPAVWVLTRR 344 L D P+ +R++ V GN + E +R L + R Sbjct: 249 GTALLLDSPDQLALLREDPSLV-----------------GNAVEELLRYLTIGQFGGERV 291 Query: 345 AVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFS 404 A + ELGG RI G ++ A DP ++ FD R R A P A F Sbjct: 292 ATRDVELGGVRIAKGEQVVAHVLAADFDPAFVEEPERFDITR----RPA--PHLA---FG 342 Query: 405 AGKRKCPSDHFSMAQLTLITAAL 427 G +C + +L ++ L Sbjct: 343 FGAHQCIGQQLARIELQIVFETL 365 >5EX6-C nrPDB Length = 434 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 93/383 (24%), Positives = 138/383 (36%), Gaps = 70/383 (18%) Query: 56 DVVRIKLGPKTVYAVT-----NPELTGALALNPDYHIAGPLWESLEGLLGKEGVATANGP 110 DVVR LG T ++ N E+ G P + G L + + P Sbjct: 85 DVVRQVLGDHTRFSTRRRFDRNDEIGGKGVFRP-RELVGNLMDY-------------DPP 130 Query: 111 LHRRQRRTIQPAFRLDAIPAYGPIMEE-EAHALTERWQPGKTVDATSESFRVAVRVAARC 169 H R RR + P F I P +E+ L E + G D E F V C Sbjct: 131 EHTRLRRLLAPGFTHRKIRRMAPYIEQIVTERLDEMEREGSPADLI-ELFADEVPGPVLC 189 Query: 170 LLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALADLHLLVDE 229 L G D+RA +F + R + L RR A LV Sbjct: 190 ELLGVPRDDRA---------MFLQLCHRHL-------DASLSGRRRAAAGEAFSRYLVTM 233 Query: 230 IIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQA 289 + ER+ P D L ++ A+ +GD + ++E+ V ++ G + I+ I + A Sbjct: 234 VARERK----DPGDGLIGMVVAE--HGDTVTDEELRGVCVQMMLAGDDNISGMIGLGVLA 287 Query: 290 LADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLT-RRAVAE 348 L +PE +R +V A + E +R + T R A+ + Sbjct: 288 LLRNPEQIAALRGDVPAAE-----------------RAVDELIRYLTVPYAPTPRTAIED 330 Query: 349 SELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKR 408 S +G I AG ++ S RDP L D DR R A VP A F G Sbjct: 331 STVGDQVIKAGETVLCSLPTANRDPA-----LLPDADRLDVTREA-VPHVA---FGHGVH 381 Query: 409 KCPSDHFSMAQLTLITAALATKY 431 C + +L + AL ++ Sbjct: 382 HCLGAALARLELRIAYTALWRRF 404 >4OQR-A nrPDB Length = 457 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 46/167 (27%), Positives = 73/167 (43%), Gaps = 29/167 (17%) Query: 219 ALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSET 278 AL L + E++A +R S + DDLL +L+ D + ++E+ + + +L G ET Sbjct: 231 ALGKLTRYIAELVATKRLSPK--DDLLGSLITDTD-----LTDEELTNIALILLVAGHET 283 Query: 279 IASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAV 338 A+ + AL HPE + P A E++ LR+ V + Sbjct: 284 TANMLGLGTFALLQHPEQIANLDS---------PDAVEEL--LRYLSIV---------HL 323 Query: 339 WVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYD--DNLEFD 383 R A+ + EL G I G + A+ RDPK +D D L+ D Sbjct: 324 GTPNRAALEDVELEGQMIRKGDTVAIGLPAVNRDPKVFDEPDILQLD 370 >3A50-A nrPDB Length = 411 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 41/164 (25%), Positives = 72/164 (43%), Gaps = 23/164 (14%) Query: 211 PANRRFNDALADLHLLVDEIIAERRASGQKPDD-LLTALLEAKDDNGDPIGEQEIHDQVV 269 PA+ + N A+ LH + +++ +R +PDD LL++LL D +GD + ++E+ + Sbjct: 176 PADDK-NAAMGKLHGYLSDLLERKRT---EPDDALLSSLLAVSDMDGDRLSQEELVAMAM 231 Query: 270 AILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIV 329 +L G ET + I + AL HP+ + ++ ++ + + Sbjct: 232 LLLIAGHETTVNLIGNGVLALLTHPDQRKLLAEDPSLIS-----------------SAVE 274 Query: 330 EAMRLRPAVWVLTRRAVAES-ELGGYRIPAGADIIYSPYAIQRD 372 E +R V R AE G IPAG ++ A RD Sbjct: 275 EFLRFDSPVSQAPIRFTAEDVTYSGVTIPAGEMVMLGLAAANRD 318 >4XE3-A nrPDB Length = 407 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 77/330 (23%), Positives = 125/330 (37%), Gaps = 43/330 (13%) Query: 102 EGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDATSESFRV 161 +GV + P H R RR + AF + P + +L + + E V Sbjct: 91 DGVLAQDPPDHTRLRRLVGKAFTARRVEEMRPRVRSLVDSLLDDMVAHGSPADLVEFLAV 150 Query: 162 AVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALA 221 VA C L G +++R +FR M+ RL +R Sbjct: 151 PFPVAVICELLGVPLEDR---------DLFRTFSDAMLSS----TRLTAAEIQRVQQ--- 194 Query: 222 DLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIAS 281 D + +D ++A+RR + +DLL AL A DN D + + EI + V++L G ET + Sbjct: 195 DFMVYMDGLVAQRRDA--PTEDLLGALALAT-DNDDHLTKGEIVNMGVSLLIAGHETSVN 251 Query: 282 TIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVL 341 I L+ L + + + + V P A E++ LR+T V + Sbjct: 252 QITNLVHLLLTERKRYESLVADPALV----PAAVEEM--LRYTPLV---------SAGSF 296 Query: 342 TRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMK 401 R A + EL + AG + + RD + +D E D R ER ++ Sbjct: 297 VRVATEDVELSTVTVRAGEPCVVHFASANRDEEVFDHADELDFHR---ERNPHI------ 347 Query: 402 PFSAGKRKCPSDHFSMAQLTLITAALATKY 431 F G C +L +AL ++ Sbjct: 348 AFGHGAHHCIGAQLGRLELQEALSALVRRF 377 >5Y1I-A nrPDB Length = 403 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 54/213 (25%), Positives = 83/213 (38%), Gaps = 37/213 (17%) Query: 238 GQKPDDLLTALL------EAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALA 291 G + DD+L+ L E D+ IG + +L G ET A+ I AL Sbjct: 203 GDRGDDILSDLAVQVEAGEITQDDAAGIG--------MMLLGAGHETTANMIALGTLALL 254 Query: 292 DHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAES-E 350 ++PE +RD +D + + N + E +R RR AE E Sbjct: 255 ENPEQLAEVRDS------------DDPKVIV---NTVEELLRYLTIAQDTVRRIAAEDIE 299 Query: 351 LGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKC 410 +GG I AG I++ A DP Y + PDR RA A F G +C Sbjct: 300 IGGVVIKAGEGIVFPLNAANWDPDLYPEA----PDRLDIHRANARRHLA---FGYGVHQC 352 Query: 411 PSDHFSMAQLTLITAALATKYRFEQVAGSNDAV 443 + +L ++ + L + +AG+ D + Sbjct: 353 LGATLARVELQIVYSTLLRRIPTLALAGTLDEI 385 >4OQS-A nrPDB Length = 433 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 47/167 (28%), Positives = 76/167 (45%), Gaps = 29/167 (17%) Query: 219 ALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSET 278 AL L + E++A +R S + DDLL +L+ D + ++E+ + + +L G ET Sbjct: 192 ALGKLTRYIAELVATKRLSPK--DDLLGSLITDTD-----LTDEELTNIALLLLVAGHET 244 Query: 279 IASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAV 338 A+ + AL HPE ++ A+ P A E++ LR+ V + Sbjct: 245 TANMLGLGTFALLQHPE-------QIAALDS--PDAVEEL--LRYLSIV---------HL 284 Query: 339 WVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYD--DNLEFD 383 R A+ + EL G I G + A+ RDPK +D D L+ D Sbjct: 285 GTPNRAALEDVELEGQMIRKGDTVAIGLPAVNRDPKVFDEPDILQLD 331 >6GII-A nrPDB Length = 479 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 41/174 (23%), Positives = 70/174 (40%), Gaps = 25/174 (14%) Query: 257 DPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFE 316 D + + +H + AI+ ET L+ L +H + + E+ A P A E Sbjct: 291 DVVTDSYLHSMMQAIIVAAHETTVFATTNALKTLLEH----ETVWREICADPSLIPAAAE 346 Query: 317 DVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSY 376 + LR+ G V A W RR E E+ G R+P GA+I+ + D + Sbjct: 347 EC--LRYNGPV---------AGW--RRRTTREVEVEGVRLPVGANILMVVASANHDSAHF 393 Query: 377 DDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATK 430 DD FD R +N ++ F G +C + ++ ++ L+ + Sbjct: 394 DDPEFFDIGR------SNASEHL--NFGYGAHQCLGRNLGRMEMQIMIEELSRR 439 >3B98-A nrPDB Length = 475 Score = 38.5 bits (88), Expect = 0.006, Method: Compositional matrix adjust. Identities = 40/168 (23%), Positives = 73/168 (43%), Gaps = 22/168 (13%) Query: 284 MWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHT-GNVIVEAMRLRPAVWVLT 342 W++ L HPE +R+E++ GG+ + E+ +K +V+ E +RL A ++T Sbjct: 274 FWVMGYLLTHPEALRAVREEIQ---GGKHLRLEERQKNTPVFDSVLWETLRLTAAA-LIT 329 Query: 343 R-----RAVAESELGGYRIPAGADIIYSPY-AIQRDPKSYDDNLEFDPDRWLP------- 389 R + + S Y + G + P+ + Q DP+ + F DR+L Sbjct: 330 RDVTQDKKICLSNGQEYHLRRGDRLCVFPFISPQMDPQIHQQPEMFQFDRFLNADRTEKK 389 Query: 390 ---ERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFE 434 + A V KY P+ CP HF++ + + + T++ E Sbjct: 390 DFFKNGARV-KYPSVPWGTEDNLCPGRHFAVHAIKELVFTILTRFDVE 436 Score = 36.6 bits (83), Expect = 0.024, Method: Compositional matrix adjust. Identities = 13/40 (32%), Positives = 25/40 (62%), Gaps = 1/40 (2%) Query: 23 EPPVAGGGVPLLGHGWRLARDPLAFMSQLRD-HGDVVRIK 61 EPP+ G +P LGH +D F++++++ HGD+ ++ Sbjct: 19 EPPLDKGMIPWLGHALEFGKDAAKFLTRMKEKHGDIFTVR 58 >3TYW-A nrPDB Length = 417 Score = 38.1 bits (87), Expect = 0.008, Method: Compositional matrix adjust. Identities = 52/215 (24%), Positives = 83/215 (38%), Gaps = 28/215 (13%) Query: 231 IAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQAL 290 +AERR + DDL++ L+ G+ EQ + + I G ET S I L Sbjct: 209 VAERREEPR--DDLISKLVTDHLVPGNVTTEQLLSTLGITI-NAGRETTTSMIALSTLLL 265 Query: 291 ADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESE 350 D PE +R + + + P A +++ ++ + I R A + E Sbjct: 266 LDRPELPAELRKDPDLM----PAAVDELLRVLSVADSIP------------LRVAAEDIE 309 Query: 351 LGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKC 410 L G +PA +I DP+ +D DP+R R N F G +C Sbjct: 310 LSGRTVPADDGVIALLAGANHDPEQFD-----DPERVDFHRTDN----HHVAFGYGVHQC 360 Query: 411 PSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRV 445 H + +L + L + ++AG D V V Sbjct: 361 VGQHLARLELEVALETLLRRVPTLRLAGERDQVVV 395 >3WEC-A nrPDB Length = 419 Score = 38.1 bits (87), Expect = 0.009, Method: Compositional matrix adjust. Identities = 42/201 (20%), Positives = 71/201 (35%), Gaps = 29/201 (14%) Query: 237 SGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEH 296 SG P+ L+ L E GD + EI + I G ET ++TI +L + H + Sbjct: 217 SGNAPEGLVRRLSEVSH-GGDQLSVDEIAATCLLITVAGQETTSNTIGNMLITFSRHADQ 275 Query: 297 ADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESELGGYRI 356 +++R P E N + E +R P R A+ + E+ G I Sbjct: 276 FEQVR--------ANPQFIE---------NAVAEVLRFEPPAHEAGRIALEDCEVSGANI 318 Query: 357 PAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFS 416 G ++ + R+ D + P + + G C + Sbjct: 319 TKGDAVMVLLASGNREAVERGDTF-----------SVTRPDVSSLSYGRGIHHCLGSALA 367 Query: 417 MAQLTLITAALATKYRFEQVA 437 + L L+ +YR +VA Sbjct: 368 NSMLQHFLRELSQRYRSIEVA 388 >6G5O-A nrPDB Length = 399 Score = 37.7 bits (86), Expect = 0.009, Method: Compositional matrix adjust. Identities = 27/87 (31%), Positives = 48/87 (55%), Gaps = 4/87 (4%) Query: 223 LHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIAST 282 L+ +DE I RAS DD+ + LL ++ + G + ++E+ +V G +T+ + Sbjct: 172 LYHYIDEQID--RASENPGDDMYSVLLNSEFE-GRKLTKEEVKGVMVLTFAGGRDTVINA 228 Query: 283 IMWLLQALADHPEHADRIRDEVEAVTG 309 + + LA+HPE +R+R E E +TG Sbjct: 229 VTNSIAYLAEHPEALERLRKEPE-ITG 254 >5M0P-A nrPDB Length = 428 Score = 37.4 bits (85), Expect = 0.014, Method: Compositional matrix adjust. Identities = 67/303 (22%), Positives = 113/303 (37%), Gaps = 52/303 (17%) Query: 98 LLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDATSE 157 L GK + T +G H ++ + + HA T+R + V+ E Sbjct: 84 LAGKGAIHTVDGKKHVDRKALFMSLMTEGNLNYVRELTRTLWHANTQRMESMDEVNIYRE 143 Query: 158 SFRVAVRVAARCLLRGQYMDERAERLCV----------ALATVFRGMYRRMVVPLGPLYR 207 S + +V R Q E ER+ AL F+G Y+ Sbjct: 144 SIVLLTKVGTRWA-GVQAPPEDIERIATDMDIMIDSFRALGGAFKG------------YK 190 Query: 208 LPLPANRRFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEA---KDDNGDPIGEQEI 264 A RR D L + +II R+ + P+ TAL E +D G+P+ + Sbjct: 191 ASKEARRRVEDWLEE------QIIETRKGNIHPPEG--TALYEFAHWEDYLGNPMDSRTC 242 Query: 265 HDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHT 324 ++ P I + + L A+ ++P ++I+ E + A++ +++R Sbjct: 243 AIDLMNTFRP-LIAINRFVSFGLHAMNENPITREKIKSEPD-------YAYKFAQEVR-- 292 Query: 325 GNVIVEAMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDP 384 R P V L +A + + G IPAG + Y D +DD EF P Sbjct: 293 --------RYYPFVPFLPGKAKVDIDFQGVTIPAGVGLALDVYGTTHDESLWDDPNEFRP 344 Query: 385 DRW 387 +R+ Sbjct: 345 ERF 347 >2XKR-A nrPDB Length = 398 Score = 36.6 bits (83), Expect = 0.025, Method: Compositional matrix adjust. Identities = 43/207 (20%), Positives = 87/207 (42%), Gaps = 29/207 (14%) Query: 218 DALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSE 277 DA A + IA RRA P D L ++L + + +G+ + + E+ + + IL G E Sbjct: 177 DAFAAYNDFTRATIAARRAD---PTDDLVSVLVSSEVDGERLSDDELVMETLLILIGGDE 233 Query: 278 TIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPA 337 T T+ + L + + D ++ + + G I E +R Sbjct: 234 TTRHTLSGGTEQLLRNRDQWDLLQRDPSLLPGA-----------------IEEMLRWTAP 276 Query: 338 VWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPK 397 V + R A++E G + AG ++ + + ++D+ + +P+++ +R N Sbjct: 277 VKNMCRVLTADTEFHGTALCAGEKMM-----LLFESANFDEAVFCEPEKFDVQRNPN--- 328 Query: 398 YAMKPFSAGKRKCPSDHFSMAQLTLIT 424 + F G C + + +L+L+T Sbjct: 329 -SHLAFGFGTHFCLGNQLARLELSLMT 354 >3AWQ-A nrPDB Length = 415 Score = 35.8 bits (81), Expect = 0.038, Method: Compositional matrix adjust. Identities = 25/112 (22%), Positives = 43/112 (38%), Gaps = 7/112 (6%) Query: 327 VIVEAMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDR 386 + E R P + RA + E G P G ++ Y D ++ D EF P+R Sbjct: 277 FVQEVRRFYPFFPAVVARASQDFEWEGMAFPEGRQVVLDLYGSNHDAATWADPQEFRPER 336 Query: 387 WLPERAANVPKYAMKPFSAGK----RKCPSDHFSMAQLTLITAALATKYRFE 434 + RA + + P G +CP + +A + + L R++ Sbjct: 337 F---RAWDEDSFNFIPQGGGDHYLGHRCPGEWIVLAIMKVAAHLLVNAMRYD 385 >3OFT-A nrPDB Length = 396 Score = 35.8 bits (81), Expect = 0.040, Method: Compositional matrix adjust. Identities = 51/176 (28%), Positives = 77/176 (43%), Gaps = 23/176 (13%) Query: 233 ERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALAD 292 E+R + Q DDL + +L ++ G P E +L G +T+A+ I + LA Sbjct: 195 EKRMA-QPGDDLFSRIL-SEPVGGRPWTVDEARRMCRNLLFGGLDTVAAMIGMVALHLAR 252 Query: 293 HPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESELG 352 HPE +R+ + + P A + E MR P V V +R AVA+ + Sbjct: 253 HPEDQRLLRERPDLI----PAAAD-------------ELMRRYPTVAV-SRNAVADVDAD 294 Query: 353 GYRIPAGADIIYSPYAIQR-DPKSYDDNLEFDPDRWL-PERAANVPKYAMKPFSAG 406 G I G D++Y P + DP S++ E DR L P R + A + AG Sbjct: 295 GVTIRKG-DLVYLPSVLHNLDPASFEAPEEVRFDRGLAPIRHTTMGVGAHRCVGAG 349 >6G71-A nrPDB Length = 405 Score = 35.4 bits (80), Expect = 0.048, Method: Compositional matrix adjust. Identities = 21/69 (30%), Positives = 35/69 (50%) Query: 318 VRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYD 377 +R + G V E++R + ++ R+ V ++EL GY IP GA + + RD + Sbjct: 263 LRDPKLWGAVFEESIRWVAPIGMVPRQTVVDTELDGYFIPRGAKLGLCILSANRDRSVWS 322 Query: 378 DNLEFDPDR 386 D FD +R Sbjct: 323 DPDRFDIER 331 >2YJN-B nrPDB Length = 381 Score = 35.4 bits (80), Expect = 0.059, Method: Compositional matrix adjust. Identities = 34/121 (28%), Positives = 56/121 (46%), Gaps = 17/121 (14%) Query: 266 DQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTG 325 D + L G+E A+T++ + A++ P A+RI D+ P A + Sbjct: 214 DPALRALFAGAEMTANTVVDAVLAVSAEPGLAERIADD--------PAAAQ--------- 256 Query: 326 NVIVEAMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPD 385 + E +RL PA+ + R A AE LG + I G +++ A RDP+ + + D D Sbjct: 257 RTVAEVLRLHPALHLERRTATAEVRLGEHVIGEGEEVVVVVAAANRDPEVFAEPDRLDVD 316 Query: 386 R 386 R Sbjct: 317 R 317 >4C9K-A nrPDB Length = 421 Score = 35.0 bits (79), Expect = 0.063, Method: Compositional matrix adjust. Identities = 48/195 (24%), Positives = 80/195 (41%), Gaps = 32/195 (16%) Query: 230 IIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQA 289 IIA RR G DL+T +L + D G P+ + V +L G +T+ + + +++ Sbjct: 215 IIAARR--GGSGTDLITRILNVEID-GKPMPDDRALGLVSLLLLGGLDTVVNFLGFMMIY 271 Query: 290 LADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAES 349 L+ HPE +R E + G VE + R AV R V++ Sbjct: 272 LSRHPETVAEMRREPLKLQRG------------------VEELFRRFAVVSDARYVVSDM 313 Query: 350 ELGGYRIPAGADIIYSPYAIQ-RDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKR 408 E G + G D+I P A+ D + +DD + D R F+ G Sbjct: 314 EFHGTMLKEG-DLILLPTALHGLDDRHHDDPMTVDLSR---------RDVTHSTFAQGPH 363 Query: 409 KCPSDHFSMAQLTLI 423 +C H + ++T++ Sbjct: 364 RCAGMHLARLEVTVM 378 >6FH2-A nrPDB Length = 366 Score = 34.3 bits (77), Expect = 0.12, Method: Compositional matrix adjust. Identities = 22/68 (32%), Positives = 35/68 (51%), Gaps = 2/68 (2%) Query: 187 LATVFRGMYRRMVVPLGPLYRLP--LPANRRFNDALADLHLLVDEIIAERRASGQKPDDL 244 L V RG Y LG ++++ + + D +ADLH +V+++IA+ RA+ Q Sbjct: 206 LGLVVRGTYGEGSEALGNIFQISNQITLGKSEEDIVADLHTIVEQLIAQERAARQALVKT 265 Query: 245 LTALLEAK 252 L LE K Sbjct: 266 LGIQLEDK 273 >5XW2-A nrPDB Length = 419 Score = 33.9 bits (76), Expect = 0.14, Method: Compositional matrix adjust. Identities = 60/281 (21%), Positives = 105/281 (37%), Gaps = 33/281 (11%) Query: 110 PLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVD-ATSESFRVAVRVAAR 168 P HR R+ + AF + P + L + T D T+ ++ + V V A Sbjct: 100 PDHRELRKLVSHAFTPKVVAELEPRITALTQELLDAVADRDTFDLMTALAYPLPVTVVAE 159 Query: 169 CLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPAN--RRFNDALADLHLL 226 L + A +F G +V LG + P + R F +A + + Sbjct: 160 LL-----------SIPSADRHLFEGWMTEIVHSLGDVSMEDAPEDQERIFEAGMAPMRKM 208 Query: 227 VDEIIAERRASGQKP-DDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMW 285 ++ + ++P DL+ L+EA+ D G + + I + +L G T I Sbjct: 209 LEYLREHAAECRRRPRGDLMGKLIEAEVD-GRRLTDNHIVNFAKMLLIAGYLTTTMLIGN 267 Query: 286 LLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRA 345 + L +PE A R+R + + G ++ E+MR V R Sbjct: 268 TVLCLDSYPEQAARVRADRSLIPG-----------------LLEESMRFLSPVAATYRAT 310 Query: 346 VAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDR 386 + E+ G R+ A ++ A RD + + + FD R Sbjct: 311 TRDVEVAGQRLSADQMVMVWFGAANRDARQFAEPELFDMTR 351 >2UUQ-A nrPDB Length = 414 Score = 33.9 bits (76), Expect = 0.14, Method: Compositional matrix adjust. Identities = 46/195 (23%), Positives = 74/195 (37%), Gaps = 30/195 (15%) Query: 218 DALADLHLLVDEIIAERRASGQKPDDLLTALLEAK-DDNGDPIGEQEIHDQVVAILTPGS 276 DA+ + +I RR + DD ++ L+ A +GD G I ++T G+ Sbjct: 195 DAVGSMMAYFTGLIERRRT--EPADDAISHLVAAGVGADGDTAGTLSILAFTFTMVTGGN 252 Query: 277 ETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRP 336 +T+ + + L P+ + D+ E + P A E E +RL Sbjct: 253 DTVTGMLGGSMPLLHRRPDQRRLLLDDPEGI----PDAVE-------------ELLRLTS 295 Query: 337 AVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYD-DNLEFDPDRWLPERAANV 395 V L R + +G IPAG ++ + RD + Y D E D R Sbjct: 296 PVQGLARTTTRDVTIGDTTIPAGRRVLLLYGSANRDERQYGPDAAELDVTR--------C 347 Query: 396 PKYAMKPFSAGKRKC 410 P+ + FS G C Sbjct: 348 PRNILT-FSHGAHHC 361 >6B11-A nrPDB Length = 440 Score = 33.9 bits (76), Expect = 0.14, Method: Compositional matrix adjust. Identities = 45/201 (22%), Positives = 82/201 (40%), Gaps = 29/201 (14%) Query: 227 VDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWL 286 +D +I+ + +G++ D + + A+ G + ++ D V +L G ET AS + Sbjct: 235 LDRLISGK--TGRESGDGMLGSMVAQARGGG-LSHADVLDNAVLLLAAGHETTASMVTMS 291 Query: 287 LQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAV 346 + L HP E+ G P A +++ LR+ I + +R R A Sbjct: 292 VLVLLQHPT----AWRELTVNPGLLPGAVDEL--LRYLS--IADGLR---------RSAT 334 Query: 347 AESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAG 406 A+ E+ G+ I AG +++ A RD + + FD R A F G Sbjct: 335 ADIEIDGHTIRAGDGLVFLLAAANRDEAVFSEPEAFDIHRSARRHVA---------FGYG 385 Query: 407 KRKCPSDHFSMAQLTLITAAL 427 +C + + +L + A+ Sbjct: 386 PHQCLGQNLARMELEVALGAV 406 >4DO1-A nrPDB Length = 410 Score = 33.5 bits (75), Expect = 0.20, Method: Compositional matrix adjust. Identities = 35/140 (25%), Positives = 52/140 (37%), Gaps = 18/140 (12%) Query: 247 ALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEA 306 A + A D G+ I E V ++L+ G +T + I + LA P R+R + Sbjct: 223 ACIHAFTDTGE-ITPDEAPLLVRSLLSAGLDTTVNGIGAAVYCLARFPGELQRLRSDPTL 281 Query: 307 VTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSP 366 N EA+R V R E ELGG I G ++ Sbjct: 282 AR-----------------NAFEEAVRFESPVQTFFRTTTREVELGGAVIGEGEKVLMFL 324 Query: 367 YAIQRDPKSYDDNLEFDPDR 386 + RDP+ + D +D R Sbjct: 325 GSANRDPRRWSDPDLYDITR 344 >6CVC-A nrPDB Length = 433 Score = 33.5 bits (75), Expect = 0.22, Method: Compositional matrix adjust. Identities = 35/144 (24%), Positives = 61/144 (42%), Gaps = 17/144 (11%) Query: 243 DLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRD 302 DL T+L+EA+ D G+ + EI + ++ G+ET + I + AL+ +P+ Sbjct: 241 DLTTSLVEAEVD-GERLSSSEIAMFFILLVVAGNETTRNAISHGMLALSRYPDE------ 293 Query: 303 EVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESELGGYRIPAGADI 362 R + D L T + E +R V + R + +L G ++ AG + Sbjct: 294 --------RAKWWSDFDGLAATA--VEEIVRWASPVVYMRRTLSQDVDLRGTKMAAGDKV 343 Query: 363 IYSPYAIQRDPKSYDDNLEFDPDR 386 + RD + + D FD R Sbjct: 344 TLWYCSANRDEEKFADPWTFDVTR 367 >3AHE-A nrPDB Length = 845 Score = 32.7 bits (73), Expect = 0.30, Method: Compositional matrix adjust. Identities = 27/91 (29%), Positives = 39/91 (42%), Gaps = 10/91 (10%) Query: 19 PELREPPVAGGGVPLLGHGWRLARDPLAFMSQLRDHGDVVRIKLGPKTVYAVTNPELTGA 78 PEL + V G V GHGW P A + RD IK P + + + P+ T + Sbjct: 409 PELDQYEVTG--VKEYGHGWGQVEAPRALGAYCRD-----IIKNNPDS-FRIFGPDETAS 460 Query: 79 LALNPDYHIAGPLWES--LEGLLGKEGVATA 107 LN Y + W++ L GL+ + T Sbjct: 461 NRLNATYEVTDKQWDNGYLSGLVDEHMAVTG 491 >2QBO-A nrPDB Length = 421 Score = 32.3 bits (72), Expect = 0.48, Method: Compositional matrix adjust. Identities = 27/103 (26%), Positives = 47/103 (45%), Gaps = 7/103 (6%) Query: 216 FNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPG 275 F +A L+ + II +RR QKP +++ NG PI E +L G Sbjct: 194 FAEAKEALYDYLIPIIEQRR---QKPGTDAISIVANGQVNGRPITSDEAKRMCGLLLVVG 250 Query: 276 SETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDV 318 +T+ + + + ++ LA PEH + + E + P A E++ Sbjct: 251 LDTVVNFLSFSMEFLAKSPEHRQELIERPERI----PAACEEL 289 >6HQG-A nrPDB Length = 425 Score = 32.0 bits (71), Expect = 0.65, Method: Compositional matrix adjust. Identities = 66/333 (19%), Positives = 123/333 (36%), Gaps = 43/333 (12%) Query: 110 PLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDATSESFRVAVRVAARC 169 P H QR+T+QP + + PI+ E A + + G+ ++ + + Sbjct: 108 PKHDVQRKTVQPIVAPNHLAYLEPIIRERAGKILDDLPIGEEINWVDKVSIELTTMTLAT 167 Query: 170 LLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALADLHLLVDE 229 L + D R +AT P + P N L VD Sbjct: 168 LFDFPWEDRRKLTFWSDVATS---------APESGILGTTDPEEHE-NLRRQTLFECVDY 217 Query: 230 II---AERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWL 286 + ER + KPD L ++L A ++ + E ++ ++ G++T +TI Sbjct: 218 FMRLWNERVNAPPKPD--LISML-AHGESTKNMDRMEYLGNLILLIVGGNDTTRNTISGS 274 Query: 287 LQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAV 346 + AL +P+ ++R+ + ++ E +R + + + RRA Sbjct: 275 VLALHQNPDQDRKLRENPGLIPA-----------------MVSETIRWQTPLAYMRRRAK 317 Query: 347 AESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMK-PFSA 405 + ELGG I G + + RD + D P+ + ER P+ F Sbjct: 318 RDFELGGKTIREGDKVAMWYVSGNRDEEVID-----RPNDYWIER----PRVRQHLSFGF 368 Query: 406 GKRKCPSDHFSMAQLTLITAALATKYRFEQVAG 438 G +C + + QL +I + ++ +V G Sbjct: 369 GVHRCVGNRLAELQLKIIWEEILARFPRLEVVG 401 >1LG9-A nrPDB Length = 398 Score = 31.6 bits (70), Expect = 0.74, Method: Compositional matrix adjust. Identities = 59/268 (22%), Positives = 99/268 (36%), Gaps = 46/268 (17%) Query: 110 PLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHA-LTERWQPGKTVDATSESFRVAVRV--A 166 P H R RR + P F L + P +E+ + L E + G D + VA +V A Sbjct: 94 PEHTRLRRKLTPGFTLRKMQRMAPYIEQIVNDRLDEMERAGSPADLIA---FVADKVPGA 150 Query: 167 ARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALADLHLL 226 C L G D+R + + + + ++ LG + L Sbjct: 151 VLCELVGVPRDDRDMFMKLCHGHLDASLSQKRRAALGDKFS----------------RYL 194 Query: 227 VDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWL 286 + I ER+ G+ ++ A++ + GD ++E+ V ++ G + I+ I Sbjct: 195 LAMIARERKEPGEG---MIGAVVA---EYGDDATDEELRGFCVQVMLAGDDNISGMIGLG 248 Query: 287 LQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAV 346 + A+ HPE D R + ++ + E +R + T R Sbjct: 249 VLAMLRHPEQIDAFRGDEQSAQ-----------------RAVDELIRYLTVPYSPTPRIA 291 Query: 347 AES-ELGGYRIPAGADIIYSPYAIQRDP 373 E L G I G +I S A RDP Sbjct: 292 REDLTLAGQEIKKGDSVICSLPAANRDP 319 >5LIV-A nrPDB Length = 450 Score = 31.2 bits (69), Expect = 0.90, Method: Compositional matrix adjust. Identities = 48/187 (25%), Positives = 74/187 (39%), Gaps = 32/187 (17%) Query: 226 LVDEIIAERRASGQKPDDLLTALLEA-KDDNGDPIGEQEIHDQVV-AILTPGSETIASTI 283 L+ E++ R S D LL +L K ++ D I E Q+V +++ G ET + + Sbjct: 234 LITEVV--ERESRDTSDTLLGEILRTLKAEHMDTI---EASRQIVLSLILGGYETTSWLV 288 Query: 284 MWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTR 343 + AL HP+ R+R + + P A E E MR P+ + + R Sbjct: 289 ANTIHALLAHPDTLARVRQDPSLL----PAAIE-------------EGMRWCPSSFGVLR 331 Query: 344 RAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPF 403 + L + AG + + A D +Y +D DR P AANV F Sbjct: 332 MVERDVRLDDQALSAGTVVCLAGIAGNYDETAYPSPEVYDIDRK-PLPAANV-------F 383 Query: 404 SAGKRKC 410 G C Sbjct: 384 GGGAHFC 390 >6F88-A nrPDB Length = 400 Score = 31.2 bits (69), Expect = 1.0, Method: Compositional matrix adjust. Identities = 48/187 (25%), Positives = 74/187 (39%), Gaps = 32/187 (17%) Query: 226 LVDEIIAERRASGQKPDDLLTALLEA-KDDNGDPIGEQEIHDQVV-AILTPGSETIASTI 283 L+ E++ R S D LL +L K ++ D I E Q+V +++ G ET + + Sbjct: 184 LITEVV--ERESRDTSDTLLGEILRTLKAEHMDTI---EASRQIVLSLILGGYETTSWLV 238 Query: 284 MWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTR 343 + AL HP+ R+R + + P A E E MR P+ + + R Sbjct: 239 ANTIHALLAHPDTLARVRQDPSLL----PAAIE-------------EGMRWCPSNFGVLR 281 Query: 344 RAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPF 403 + L + AG + + A D +Y +D DR P AANV F Sbjct: 282 MVERDVRLDDQALSAGTVVCLAGIAGNYDETAYPSPEVYDIDRK-PLPAANV-------F 333 Query: 404 SAGKRKC 410 G C Sbjct: 334 GGGAHFC 340 >5M73-D nrPDB Length = 158 Score = 30.0 bits (66), Expect = 2.4, Method: Compositional matrix adjust. Identities = 11/19 (57%), Positives = 14/19 (73%) Query: 373 PKSYDDNLEFDPDRWLPER 391 PK+YD + DP+RWLP R Sbjct: 53 PKNYDPKVTPDPERWLPMR 71 >2ZQJ-A nrPDB Length = 417 Score = 29.3 bits (64), Expect = 3.7, Method: Compositional matrix adjust. Identities = 73/375 (19%), Positives = 135/375 (36%), Gaps = 52/375 (13%) Query: 52 RDHGDVVRIKLGPKTVYAVTNPELTGALALNPDYHIAGPLWESLE-GLLGKEGVATANGP 110 R + D+ + +L K +T E + L + ++ L G + +G Sbjct: 31 RYNSDLFQARLLGKNFICMTGAEAAKVFYDTDRFQRQNALPKRVQKSLFGVNAIQGMDGS 90 Query: 111 LHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDATSESFRVAVRVA---A 167 H ++ +M EE A RW+ V E+ + RVA A Sbjct: 91 AHIHRKMLFLSLMTPPHQKRLAELMTEEWKAAVTRWEKADEVVLFEEAKEILCRVACYWA 150 Query: 168 RCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALADLHLLV 227 L+ + ERA+ + + F +GP + A R + + Sbjct: 151 GVPLKETEVKERADDF-IDMVDAFGA--------VGPRHWKGRRARPRAEEWI------- 194 Query: 228 DEIIAERRASGQKPDDLLTALLEA---KDDNGDPIGEQEIHDQVVAILTPGSETIASTIM 284 E++ E +G TAL E ++G + + +++ +L P +A + Sbjct: 195 -EVMIEDARAGLLKTTSGTALHEMAFHTQEDGSQLDSRMAAIELINVLRP---IVAISYF 250 Query: 285 WLLQALA--DHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLT 342 + ALA +HP++ + +R + R + ++VR+ G + A+ + VW Sbjct: 251 LVFSALALHEHPKYKEWLRS---GNSREREMFVQEVRRYYPFGPFL-GALVKKDFVW--- 303 Query: 343 RRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKP 402 G ++ Y DP+ +D EF P+R ER N+ + M P Sbjct: 304 ---------NNCEFKKGTSVLLDLYGTNHDPRLWDHPDEFRPER-FAEREENL--FDMIP 351 Query: 403 FSAGK----RKCPSD 413 G +CP + Sbjct: 352 QGGGHAEKGHRCPGE 366 >5OMS-A nrPDB Length = 409 Score = 29.3 bits (64), Expect = 3.7, Method: Compositional matrix adjust. Identities = 21/90 (23%), Positives = 34/90 (37%), Gaps = 10/90 (11%) Query: 328 IVEAMRLRPAVWVLTRR-AVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDR 386 I E +R +W T R + + G +PAG ++ S + D Y+ ++D R Sbjct: 284 IAEGLRWTSPIWSATARISTKPVTIAGVDLPAGTPVMLSYGSANHDTGKYEAPSQYDLHR 343 Query: 387 WLPERAANVPKYAMKPFSAGKRKCPSDHFS 416 P F AG C +F+ Sbjct: 344 ---------PPLPHLAFGAGNHACAGIYFA 364 >6F0B-A nrPDB Length = 395 Score = 28.9 bits (63), Expect = 5.2, Method: Compositional matrix adjust. Identities = 33/153 (21%), Positives = 59/153 (38%), Gaps = 25/153 (16%) Query: 268 VVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNV 327 ++ ++ G +T ASTI L + A PE + + E + P+ E++ + + Sbjct: 227 ILMLIVGGYDTTASTISLSLVSYALQPEKFSVVHEHPERI----PLLVEELLRYHTVSQL 282 Query: 328 IVEAMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRW 387 L R A + E+GG + AG ++ + RD + + E D DR Sbjct: 283 ------------GLGRIATEDVEVGGVTVRAGQMVVAALPLANRDESVFPNPDELDFDR- 329 Query: 388 LPERAANVPKYAMKPFSAGKRKCPSDHFSMAQL 420 +VP F G +C + +L Sbjct: 330 -----PSVPHVG---FGYGPHQCVGQALARVEL 354 >6FRK-r nrPDB Length = 605 Score = 28.9 bits (63), Expect = 5.5, Method: Compositional matrix adjust. Identities = 11/19 (57%), Positives = 14/19 (73%) Query: 373 PKSYDDNLEFDPDRWLPER 391 PK+YD + DP+RWLP R Sbjct: 563 PKNYDPKVTPDPERWLPMR 581 >5L9W-B nrPDB Length = 732 Score = 28.5 bits (62), Expect = 6.5, Method: Compositional matrix adjust. Identities = 21/82 (25%), Positives = 40/82 (48%), Gaps = 14/82 (17%) Query: 231 IAERR--ASGQKP-----DDLLTALLEAKDDNGD---PIGEQEIHDQVVAILTPGSETIA 280 +AERR A KP DL+ + E D +G P+ E+++ ++ ++ G+ I Sbjct: 118 VAERRNIAVQNKPLPLIERDLILGVRERIDSSGSVVRPLDEEDVRTKLRMLMDRGARAIV 177 Query: 281 STIMWLLQALADHPEHADRIRD 302 +++W +P H R+R+ Sbjct: 178 VSLLWSFM----NPAHEKRVRE 195 >5XWF-A nrPDB Length = 378 Score = 28.5 bits (62), Expect = 6.7, Method: Compositional matrix adjust. Identities = 23/95 (24%), Positives = 42/95 (44%), Gaps = 4/95 (4%) Query: 105 ATANGPLHRRQRRT-IQPAFRLDAIPAY---GPIMEEEAHALTERWQPGKTVDATSESFR 160 A AN PL+ + T ++P DA+ A+ G E+ + + KT++ + S Sbjct: 191 AGANAPLYYSPKVTGVEPTSGNDAVKAWIAAGIPAEQLVLGVPFYGRVSKTLEPITASTG 250 Query: 161 VAVRVAARCLLRGQYMDERAERLCVALATVFRGMY 195 + V ++ ++G DE+A C + G Y Sbjct: 251 LYVPISQSSQIKGDSTDEKAADPCPNAVATYSGQY 285 >1WZ2-A nrPDB Length = 967 Score = 28.1 bits (61), Expect = 7.7, Method: Compositional matrix adjust. Identities = 24/76 (31%), Positives = 36/76 (47%), Gaps = 16/76 (21%) Query: 17 GAPELREPPVAGGGVPLLGHGWRLARDP-----LAFMSQLRDHGDVVRI---KLGPKTVY 68 GA +R PV G PL H D + +LR++G+V+ + L P+TVY Sbjct: 179 GAHRVRWDPVVG--TPLGDHDLMEGEDVPILDYIIIKFELRENGEVIYLPAATLRPETVY 236 Query: 69 AVTNPELTGALALNPD 84 VTN + +NP+ Sbjct: 237 GVTN------MWVNPN 246 >5Z9I-A nrPDB Length = 398 Score = 28.1 bits (61), Expect = 8.3, Method: Compositional matrix adjust. Identities = 37/156 (23%), Positives = 62/156 (39%), Gaps = 20/156 (12%) Query: 233 ERRASGQKP--DDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQAL 290 ER A +K +DL++ L+ A+ D G + + +I + +L G T A I + L Sbjct: 195 ERAAESRKRPREDLISQLVHAEVD-GQKLNDSQISNIANRLLVNGHLTTAMLIANTMLCL 253 Query: 291 ADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESE 350 + R+R + V P E E+MR + + R +E E Sbjct: 254 DAFSDQDARVRADRSLV----PALLE-------------ESMRYMSPICGVGRATNSEVE 296 Query: 351 LGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDR 386 + G IP ++ A RD + ++ FD R Sbjct: 297 VAGTVIPKDQLLLVWTGAANRDERQFEKPDVFDAGR 332 >1WKB-A nrPDB Length = 810 Score = 28.1 bits (61), Expect = 9.5, Method: Compositional matrix adjust. Identities = 24/76 (31%), Positives = 36/76 (47%), Gaps = 16/76 (21%) Query: 17 GAPELREPPVAGGGVPLLGHGWRLARDP-----LAFMSQLRDHGDVVRI---KLGPKTVY 68 GA +R PV G PL H D + +LR++G+V+ + L P+TVY Sbjct: 179 GAHRVRWDPVVG--TPLGDHDLMEGEDVPILDYIIIKFELRENGEVIYLPAATLRPETVY 236 Query: 69 AVTNPELTGALALNPD 84 VTN + +NP+ Sbjct: 237 GVTN------MWVNPN 246 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 3EL3-A nrPDB 531 e-151 3JUS-A nrPDB 351 3e-97 6B82-A nrPDB 342 2e-94 6AYB-A nrPDB 335 2e-92 5E58-A nrPDB 333 6e-92 2WX2-A nrPDB 332 3e-91 4H1N-A nrPDB 328 4e-90 5E0E-A nrPDB 326 2e-89 3L4D-A nrPDB 325 2e-89 4WMZ-A nrPDB 325 2e-89 2VE3-A nrPDB 324 6e-89 4R20-A nrPDB 323 9e-89 6CR2-A nrPDB 318 2e-87 2NNH-A nrPDB 318 2e-87 5JLC-A nrPDB 317 8e-87 3IBD-A nrPDB 317 8e-87 2X2N-A nrPDB 316 2e-86 2PG7-A nrPDB 315 3e-86 5W0C-A nrPDB 313 7e-86 3E6I-A nrPDB 310 1e-84 1N6B-A nrPDB 309 1e-84 5FSA-A nrPDB 309 2e-84 4GQS-A nrPDB 308 4e-84 4R1Z-A nrPDB 304 5e-83 6DA2-A nrPDB 297 6e-81 6DWN-A nrPDB 296 1e-80 5VEU-A nrPDB 296 2e-80 5UYS-A nrPDB 294 5e-80 2W0A-A nrPDB 292 2e-79 2HI4-A nrPDB 290 7e-79 5YLW-A nrPDB 288 4e-78 5CJE-A nrPDB 285 3e-77 3EJB-B nrPDB 283 1e-76 4KPA-A nrPDB 279 2e-75 3MDV-A nrPDB 279 2e-75 6C94-A nrPDB 277 6e-75 3DL9-A nrPDB 277 8e-75 3TBG-A nrPDB 272 2e-73 2VZM-A nrPDB 263 1e-70 5OFQ-A nrPDB 262 3e-70 5VBU-A nrPDB 259 2e-69 5VWS-A nrPDB 257 8e-69 3QZ1-A nrPDB 254 5e-68 3MZS-A nrPDB 253 1e-67 5L94-A nrPDB 251 4e-67 4UBS-A nrPDB 249 2e-66 3WVS-A nrPDB 248 3e-66 3NC3-A nrPDB 247 7e-66 4YZR-A nrPDB 247 7e-66 3A50-A nrPDB 247 8e-66 1UED-A nrPDB 247 9e-66 6IQ5-A nrPDB 247 9e-66 4RM4-A nrPDB 246 2e-65 1Z8P-A nrPDB 246 2e-65 4Z5Q-A nrPDB 243 1e-64 3N9Z-A nrPDB 242 3e-64 1ODO-A nrPDB 241 4e-64 2Y5N-A nrPDB 241 4e-64 5LIE-A nrPDB 241 4e-64 4JBT-A nrPDB 241 5e-64 4Z5P-A nrPDB 236 1e-62 2ZBZ-A nrPDB 236 1e-62 5IT1-A nrPDB 236 1e-62 3ABB-A nrPDB 236 2e-62 3R9C-A nrPDB 235 2e-62 6A7J-A nrPDB 235 5e-62 5EX6-C nrPDB 233 1e-61 2Z36-A nrPDB 233 2e-61 1GWI-A nrPDB 232 2e-61 3SN5-A nrPDB 231 4e-61 6GMF-A nrPDB 231 5e-61 3K9V-A nrPDB 230 9e-61 5NWS-A nrPDB 230 1e-60 4MM0-A nrPDB 229 1e-60 6A7I-A nrPDB 229 2e-60 4WPZ-A nrPDB 228 4e-60 1CPT-A nrPDB 228 6e-60 3ABA-A nrPDB 226 1e-59 2WIO-A nrPDB 224 5e-59 5DQN-A nrPDB 224 8e-59 5FOI-A nrPDB 222 2e-58 4GGV-A nrPDB 222 2e-58 6GK6-A nrPDB 219 1e-57 4OQR-A nrPDB 218 3e-57 3S79-A nrPDB 215 3e-56 2WM5-A nrPDB 215 4e-56 1EHE-A nrPDB 214 9e-56 3RWL-A nrPDB 213 2e-55 4TRI-A nrPDB 213 2e-55 3TKT-A nrPDB 211 8e-55 3IVY-A nrPDB 204 9e-53 3MGX-A nrPDB 203 2e-52 5FYF-A nrPDB 202 2e-52 5XJN-A nrPDB 201 7e-52 5GWE-A nrPDB 201 8e-52 1WIY-A nrPDB 200 9e-52 5DE9-A nrPDB 196 2e-50 3P3Z-A nrPDB 196 2e-50 2FR7-A nrPDB 193 1e-49 4PWV-A nrPDB 192 3e-49 3A1L-A nrPDB 190 1e-48 5D3U-A nrPDB 188 5e-48 6DCD-A nrPDB 186 1e-47 6FYJ-A nrPDB 186 2e-47 6BLD-A nrPDB 184 7e-47 4ZGX-A nrPDB 179 3e-45 6M7X-A nrPDB 178 5e-45 5YHJ-A nrPDB 177 7e-45 2WIY-A nrPDB 177 1e-44 3BUJ-A nrPDB 166 1e-41 2IAG-A nrPDB 127 1e-29 3DBM-A nrPDB 114 1e-25 2RCM-A nrPDB 105 4e-23 Sequences not found previously or not previously below threshold: 4XE3-A nrPDB 227 7e-60 4OQS-A nrPDB 220 1e-57 5XNT-A nrPDB 219 1e-57 6FSH-A nrPDB 218 4e-57 4YT3-A nrPDB 217 9e-57 1LG9-A nrPDB 214 6e-56 4TX3-A nrPDB 214 6e-56 6HQG-A nrPDB 214 8e-56 5YSW-A nrPDB 212 3e-55 6CVC-A nrPDB 211 6e-55 6B11-A nrPDB 211 6e-55 5XW2-A nrPDB 209 2e-54 5Y1I-A nrPDB 209 2e-54 3TYW-A nrPDB 205 4e-53 2XKR-A nrPDB 198 5e-51 5Z9I-A nrPDB 195 3e-50 1Q5D-A nrPDB 193 2e-49 6M7L-A nrPDB 192 3e-49 3OO3-A nrPDB 189 2e-48 2UUQ-A nrPDB 189 2e-48 6HQW-A nrPDB 188 3e-48 6HQD-A nrPDB 188 5e-48 5L1U-A nrPDB 186 2e-47 4DO1-A nrPDB 184 5e-47 5HH3-A nrPDB 183 1e-46 1F4U-A nrPDB 183 2e-46 2NZA-A nrPDB 180 1e-45 6F0B-A nrPDB 179 2e-45 6GII-A nrPDB 179 3e-45 3WEC-A nrPDB 174 7e-44 5H1Z-A nrPDB 174 7e-44 5EX8-A nrPDB 171 5e-43 2X9P-A nrPDB 171 7e-43 5HDI-A nrPDB 169 2e-42 2RFC-A nrPDB 168 5e-42 1UE8-A nrPDB 168 5e-42 6G5O-A nrPDB 154 7e-38 5LIV-A nrPDB 153 1e-37 6F88-A nrPDB 153 2e-37 5OMS-A nrPDB 151 8e-37 6G71-A nrPDB 149 3e-36 5HIW-A nrPDB 149 3e-36 3OFT-A nrPDB 146 1e-35 4FB2-A nrPDB 145 5e-35 2ZQJ-A nrPDB 144 7e-35 3AWQ-A nrPDB 139 4e-33 3NV6-A nrPDB 134 7e-32 5M0P-A nrPDB 134 8e-32 5KYO-A nrPDB 130 1e-30 2QBO-A nrPDB 129 2e-30 2IJ7-A nrPDB 127 8e-30 3B98-A nrPDB 127 1e-29 4C9K-A nrPDB 127 1e-29 2YJN-B nrPDB 69 5e-12 3IAC-A nrPDB 32 0.57 5L9W-B nrPDB 31 0.86 4YXC-B nrPDB 31 1.1 4YXB-D nrPDB 30 2.6 3RFT-A nrPDB 29 3.6 6MDR-a nrPDB 29 3.7 1BWD-A nrPDB 28 8.4 3OQB-A nrPDB 28 9.5 1PQ3-A nrPDB 28 9.9 >3EL3-A nrPDB Length = 467 Score = 531 bits (1369), Expect = e-151, Method: Composition-based stats. Identities = 461/461 (100%), Positives = 461/461 (100%) Query: 1 MTVESVNPETRAPAAPGAPELREPPVAGGGVPLLGHGWRLARDPLAFMSQLRDHGDVVRI 60 MTVESVNPETRAPAAPGAPELREPPVAGGGVPLLGHGWRLARDPLAFMSQLRDHGDVVRI Sbjct: 1 MTVESVNPETRAPAAPGAPELREPPVAGGGVPLLGHGWRLARDPLAFMSQLRDHGDVVRI 60 Query: 61 KLGPKTVYAVTNPELTGALALNPDYHIAGPLWESLEGLLGKEGVATANGPLHRRQRRTIQ 120 KLGPKTVYAVTNPELTGALALNPDYHIAGPLWESLEGLLGKEGVATANGPLHRRQRRTIQ Sbjct: 61 KLGPKTVYAVTNPELTGALALNPDYHIAGPLWESLEGLLGKEGVATANGPLHRRQRRTIQ 120 Query: 121 PAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDATSESFRVAVRVAARCLLRGQYMDERA 180 PAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDATSESFRVAVRVAARCLLRGQYMDERA Sbjct: 121 PAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDATSESFRVAVRVAARCLLRGQYMDERA 180 Query: 181 ERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQK 240 ERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQK Sbjct: 181 ERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQK 240 Query: 241 PDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRI 300 PDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRI Sbjct: 241 PDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRI 300 Query: 301 RDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESELGGYRIPAGA 360 RDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESELGGYRIPAGA Sbjct: 301 RDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESELGGYRIPAGA 360 Query: 361 DIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQL 420 DIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQL Sbjct: 361 DIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQL 420 Query: 421 TLITAALATKYRFEQVAGSNDAVRVGITLRPHDLLVRPVAR 461 TLITAALATKYRFEQVAGSNDAVRVGITLRPHDLLVRPVAR Sbjct: 421 TLITAALATKYRFEQVAGSNDAVRVGITLRPHDLLVRPVAR 461 >3JUS-A nrPDB Length = 461 Score = 351 bits (901), Expect = 3e-97, Method: Composition-based stats. Identities = 105/447 (23%), Positives = 195/447 (43%), Gaps = 9/447 (2%) Query: 21 LREPPVAGGGVPLLGHGWRLARDPLAFMSQ-LRDHGDVVRIKLGPKTVYAVTNPELTGAL 79 ++ PP +P LGH + P+ F+ +G V + KT + + L Sbjct: 10 VKSPPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALL 69 Query: 80 ALNPDYHI-AGPLWESLE-GLLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEE 137 + + + A ++ L + GK P+ Q++ ++ + + I+E+ Sbjct: 70 FNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEK 129 Query: 138 EAHALTERWQPGKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRR 197 E E W + + + A+ CL + + E++ A + G Sbjct: 130 ETKEYFESWGESGEKNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGFSHA 189 Query: 198 MVVPLGPLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGD 257 + G LPLP+ RR + A ++ + + I +RR S +K DD+L LL+A +G Sbjct: 190 AWLLPG---WLPLPSFRRRDRAHREIKDIFYKAIQKRRQSQEKIDDILQTLLDATYKDGR 246 Query: 258 PIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGR--PVAF 315 P+ + E+ ++ +L G T ++T W+ LA + E + V G P+ + Sbjct: 247 PLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTY 306 Query: 316 EDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKS 375 + ++ L I E +RLRP + ++ R A + GY IP G + SP QR S Sbjct: 307 DQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDS 366 Query: 376 YDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQ 435 + + L+F+PDR+L + A+ K+A PF AG+ +C ++F+ Q+ I + + Y F+ Sbjct: 367 WVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDL 426 Query: 436 VAGS-NDAVRVGITLRPHDLLVRPVAR 461 + G + P + ++R R Sbjct: 427 IDGYFPTVNYTTMIHTPENPVIRYKRR 453 >6B82-A nrPDB Length = 509 Score = 342 bits (878), Expect = 2e-94, Method: Composition-based stats. Identities = 102/474 (21%), Positives = 183/474 (38%), Gaps = 30/474 (6%) Query: 18 APELREPPVAGGGVPLLGHGWRLARD--PLAFMSQL-RDHGDVVRIKLGPKTVYAVTNPE 74 P P + +P++G L D P F L + +GD+ + +G + V N Sbjct: 18 VPAGNRSPPSLPSLPIIGSLMSLVSDSPPHIFFQDLQKKYGDLYSLMMGSHKLLIVNNHH 77 Query: 75 LTGALALNPDYHIAGPLWESLEGLLGKEG--VATANGP-LHRRQRRTIQPAFRL--DAIP 129 + + AG LL ++G +A A+ + R+ + A + + Sbjct: 78 HAKEILIKKGKIFAGRPRTVTTDLLTRDGKDIAFADYSSTWKFHRKMVHGALCMFGEGSV 137 Query: 130 AYGPIMEEEAHALTERWQPGK--TVDATSESFRVAVRVAARCLLRGQYM--DERAERLCV 185 + I+ EA ++ E + VD E R V Y D E + Sbjct: 138 SIEKIICREASSMCEVLTESQNSAVDLGPELTRAVTNVVCALCFNSSYKRGDAEFESMLQ 197 Query: 186 ALATVFRGMYRRMVVPLGPLYR-LPLPANRRFNDALADLHLLVDEIIAERRASGQK--PD 242 + + + +V + P + P R ++ L+ + E + + Sbjct: 198 YSQGIVDTVAKDSLVDIFPWLQIFPNKDLRILRQCISIRDKLLQKKYEEHKVTYSDNVQR 257 Query: 243 DLLTALLEAKDDNGDP--------IGEQEIHDQVVAILTPGSETIASTIMWLLQALADHP 294 DLL ALL AK + + + E + V I G ET +T+ W + L +P Sbjct: 258 DLLDALLRAKRSSENNNSSTRDVGLTEDHVLMTVGEIFGAGVETTTTTLKWSIAYLVHNP 317 Query: 295 EHADRIRDEVEAVTG-GRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVL-TRRAVAESELG 352 + +I++E+++ G R D L + I E MR+RP +L A+ +S +G Sbjct: 318 QVQRKIQEELDSKIGKERHPQLSDRGNLPYLEATICEVMRIRPVSPLLIPHVALQDSSVG 377 Query: 353 GYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANV--PKYAMKPFSAGKRKC 410 Y + G ++ + +++ D K + + FDP R+L E + P + PF AG R C Sbjct: 378 EYTVQKGTRVVINMWSLHHDEKEWKNPELFDPGRFLNEEGDGLCCPSGSYLPFGAGVRVC 437 Query: 411 PSDHFSMAQLTLITAALATKYRFEQVAGSNDA---VRVGITLRPHDLLVRPVAR 461 + + +L L A + ++ E G + G+ L+P V R Sbjct: 438 LGEALAKMELFLFLAWILQRFTLEMPTGQPLPDLQGKFGVVLQPKKFKVVAKVR 491 >6AYB-A nrPDB Length = 466 Score = 335 bits (860), Expect = 2e-92, Method: Composition-based stats. Identities = 95/454 (20%), Positives = 182/454 (40%), Gaps = 21/454 (4%) Query: 14 AAPGAPELREPPVAGGGVPLLGHGWRLARDPLAFM-SQLRDHGDVVRIKLGPKTVYAVTN 72 A + + + PP +P +G A++P+ F+ + +GDV + K + + + Sbjct: 2 AKKTSSKGKLPPRVPNLIPYVGSFVSFAKNPVQFIIDNSKKYGDVFTATILGKEMTFLNH 61 Query: 73 PELTGALALNPDYHIA-GPLWESLEGLLGKEGVATANG-PLHRRQRRTIQPAFRLDAIPA 130 P++ D ++ ++ + + G V A+ Q + + Sbjct: 62 PKILDTFFKATDNELSLRDVYRFMRPVFGTGVVYDADSTERMMEQVKFVSSGLTTARFRV 121 Query: 131 YGPIMEEEAHALTERWQPGKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATV 190 + I E+E + P TVD + + A+RCLL + +E+ L Sbjct: 122 FVDIFEDEIAHKVKELGPEGTVDVAELMADLIIFTASRCLLGDEVRQYLSEKNLGKLYHD 181 Query: 191 FRGMYRRMVVPLGPLY-RLPLPANRRFNDALADLHLLVDEIIAERRASGQKPD------- 242 + PL Y LP P + A+ ++ E++ +RR +K Sbjct: 182 I----DDGISPLSFFYPSLPAPKRDKARKAVGEI---FQELLDKRREEHKKHPERLLDES 234 Query: 243 --DLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRI 300 D++ LL K +G + + ++A L G T + T W L + + + +++ Sbjct: 235 KMDVVDHLLTQKYKDGQELTDVHRIGILIAGLFAGQHTSSITSSWTLMNVISNKKVLEKV 294 Query: 301 RDEVEAVTGGRP-VAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESELGGYRIPAG 359 R E E + G + ++ V K+ + + EA+R+ P + ++ R A E Y IP G Sbjct: 295 RKEQEEIMGSDKVLDYDKVMKMDYLEACMKEALRMYPPLIMIMRMARKPRECEQYIIPKG 354 Query: 360 ADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQ 419 ++ SP R +Y + FDP+R + KY PF AG+ KC ++F++ Q Sbjct: 355 NILVVSPSVAGRCTDTYTNPDVFDPERLTERKEHEKFKYGAVPFGAGRHKCIGENFALLQ 414 Query: 420 LTLITAALATKYRFEQVAGSNDAVRVGITLRPHD 453 + I + L + E + D + + P Sbjct: 415 VKSIISILLRYFDMEYIGKIPDPSYTSLVVGPSP 448 >5E58-A nrPDB Length = 493 Score = 333 bits (855), Expect = 6e-92, Method: Composition-based stats. Identities = 95/450 (21%), Positives = 174/450 (38%), Gaps = 24/450 (5%) Query: 36 HGWRLARDPL--AFMSQLRDHGDVVRIKLGPKTVYAVTNPE-LTGALALNPDYHIAGPLW 92 + ++ R +FM +GDV + LGP+ V + E + AL + Sbjct: 42 NLLQMDRGGFLNSFMRIREKYGDVFTVHLGPRPVVMLYGTEAIREALVDQAEAFSGRGTI 101 Query: 93 ESLEGLLGKEGVATANGPLHRRQRRTIQPAFRLDAI--PAYGPIMEEEAHALTERWQP-- 148 ++ ++G G+ +NG + RR R + + ++EEA L E Q Sbjct: 102 AVIKPVIGDYGMIFSNGERWKVLRRFSLATMRDFGMGKRSVEDRIQEEAQCLVEELQKSQ 161 Query: 149 GKTVDATSESFRVAVRVAARCLL--RGQYMDERAERLCVALATVFR--GMYRRMVVPLGP 204 G +D T + + + R Y D + RL F + V L Sbjct: 162 GAPLDPTFLFQCITANIICSIVFGERYDYKDRQFLRLLDLFYRTFSLMSSFSSQVFELFS 221 Query: 205 LYRLPLP-ANRRFNDALADLHLLVDEIIAERRASGQK--PDDLLTA-LLEAKDDNGDPIG 260 + P A+R+ L ++ V + + + RA+ P D + LL + + + Sbjct: 222 GFMKYFPGAHRQITRNLQEILDYVGQSVEKHRATLDPSNPRDFIDTYLLRMEKEKSNQHT 281 Query: 261 E---QEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGG-RPVAFE 316 E Q + V+++ G+ET ++T+ + + +P A++++ E++ V G R E Sbjct: 282 EFHHQNLLISVLSLFFAGTETTSTTLRYGFLLMLKYPHVAEKVQKEIDQVIGSHRLPTLE 341 Query: 317 DVRKLRHTGNVIVEAMRLRPAVWV-LTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKS 375 D K+ +T VI E R + + ++ GY +P ++ + DP+ Sbjct: 342 DRTKMPYTDAVIHEIQRFSDLAPIGAPHKVTKDTLFRGYLLPKNTEVYPILSSALHDPQY 401 Query: 376 YDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQ 435 ++ F+PD +L A A PFS GKR C + + +L L + + Sbjct: 402 FEQPGTFNPDHFLDANGALKKSEAFMPFSIGKRICLGEGIARNELFLFFTTILQNFSVSS 461 Query: 436 VAGSND----AVRVGITLRPHDLLVRPVAR 461 D GI P + +AR Sbjct: 462 SVAPKDIDLSPKESGIGKVPQTYQISFLAR 491 >2WX2-A nrPDB Length = 473 Score = 332 bits (850), Expect = 3e-91, Method: Composition-based stats. Identities = 101/443 (22%), Positives = 178/443 (40%), Gaps = 23/443 (5%) Query: 23 EPPVAGGGVPLLGHGWRLARDPLAFMSQLRD--HGDVVRIKLGPKTVYAVTNPELTGALA 80 +PPV VP LGH + ++PL FM + + V I +G + V V +P Sbjct: 17 DPPVYPVTVPFLGHIVQFGKNPLEFMQRCKRDLKSGVFTISIGGQRVTIVGDPHEHSRF- 75 Query: 81 LNPDYHIAGP--LWESLEGLLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEE 138 +P I P ++ + + G+ A P R Q + + + P ++ E Sbjct: 76 FSPRNEILSPREVYTIMTPVFGEGVAYAAPYPRMREQLNFLAEELTIAKFQNFVPAIQHE 135 Query: 139 AHA-LTERWQPGKTV-DATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYR 196 + E W+ + V + + + + A +CL R L + Sbjct: 136 VRKFMAENWKEDEGVINLLEDCGAMIINTACQCLFGEDLRKRLNARHFAQLLSKMESSLI 195 Query: 197 RMVVPLGPLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQKPD----DLLTALLEAK 252 V + L RLPLP + R +A A+L ++ EII R D DLL LL+A Sbjct: 196 PAAVFMPWLLRLPLPQSARCREARAELQKILGEIIVAREKEEASKDNNTSDLLGGLLKAV 255 Query: 253 DDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALAD--HPEHADRIRDEVEAVTGG 310 +G + E+ +VA + G T T W + L + + D++ E++ Sbjct: 256 YRDGTRMSLHEVCGMIVAAMFAGQHTSTITTSWSMLHLMHPKNKKWLDKLHKEIDEFPAQ 315 Query: 311 RPVAFEDVR-KLRHTGNVIVEAMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAI 369 + +++V ++ + E++R P + ++ R AE ++G Y +P G I SP Sbjct: 316 --LNYDNVMDEMPFAERCVRESIRRDPPLLMVMRMVKAEVKVGSYVVPKGDIIACSPLLS 373 Query: 370 QRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALAT 429 D +++ + +DP+R A F AG KC F++ Q+ I A Sbjct: 374 HHDEEAFPNPRLWDPER------DEKVDGAFIGFGAGVHKCIGQKFALLQVKTILATAFR 427 Query: 430 KYRFEQVAGS-NDAVRVGITLRP 451 +Y F+ + D + + P Sbjct: 428 EYDFQLLRDEVPDPDYHTMVVGP 450 >4H1N-A nrPDB Length = 479 Score = 328 bits (840), Expect = 4e-90, Method: Composition-based stats. Identities = 101/461 (21%), Positives = 180/461 (39%), Gaps = 24/461 (5%) Query: 25 PVAGGGVPLLGHGWRLARDPL--AFMSQLRDHGDVVRIKLGPKTVYAVTNPE-LTGALAL 81 P +P+LG+ ++ R L +F+ +GDV + LG + V + + + AL Sbjct: 12 PPGPSPLPVLGNLLQMDRKGLLRSFLRLREKYGDVFTVYLGSRPVVVLCGTDAIREALVD 71 Query: 82 NPDYHIAGPLWESLEGLLGKEGVATANGPLHRRQRRTIQPAFRLDAI--PAYGPIMEEEA 139 + ++ + GV ANG R RR R + + ++EEA Sbjct: 72 QAEAFSGRGKIAVVDPIFQGYGVIFANGERWRALRRFSLATMRDFGMGKRSVEERIQEEA 131 Query: 140 HALTERWQP--GKTVDATSESFRVAVRVAARCLL--RGQYMDERAERLCVALATVFRGMY 195 L E + G +D T + + + R Y D RL F + Sbjct: 132 RCLVEELRKSKGALLDNTLLFHSITSNIICSIVFGKRFDYKDPVFLRLLDLFFQSFSLIS 191 Query: 196 RR--MVVPLGPLYRLPLPA-NRRFNDALADLHLLVDEIIAERRASGQK--PDDLLTA-LL 249 V L + P +R+ L +++ + + + + RA+ P D + LL Sbjct: 192 SFSSQVFELFSGFLKYFPGTHRQIYRNLQEINTFIGQSVEKHRATLDPSNPRDFIDVYLL 251 Query: 250 EAKDDNGDPIGE---QEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEA 306 + D DP E Q + V+++ G+ET ++T+ + + +P +R++ E+E Sbjct: 252 RMEKDKSDPSSEFHHQNLILTVLSLFAAGTETTSTTLRYGFLLMLKYPHVTERVQKEIEQ 311 Query: 307 VTGG-RPVAFEDVRKLRHTGNVIVEAMRLRPAVWV-LTRRAVAESELGGYRIPAGADIIY 364 V G RP A +D K+ +T VI E RL + + +++ GY IP ++ Sbjct: 312 VIGSHRPPALDDRAKMPYTDAVIHEIQRLGDLIPFGVPHTVTKDTQFRGYVIPKNTEVFP 371 Query: 365 SPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLIT 424 + DP+ ++ F+P +L A PFS GKR C + + +L L Sbjct: 372 VLSSALHDPRYFETPNTFNPGHFLDANGALKRNEGFMPFSLGKRICLGEGIARTELFLFF 431 Query: 425 AALATKYRFEQVAGSND----AVRVGITLRPHDLLVRPVAR 461 + + D G+ P +R +AR Sbjct: 432 TTILQNFSIASPVPPEDIDLTPRESGVGNVPPSYQIRFLAR 472 >5E0E-A nrPDB Length = 463 Score = 326 bits (835), Expect = 2e-89, Method: Composition-based stats. Identities = 89/424 (20%), Positives = 165/424 (38%), Gaps = 22/424 (5%) Query: 40 LARDPLAFMSQLR----DHGDVVRIKLGPKTVYAVTNPE-LTGALALNPDYHIAGPLWES 94 L D F++ R +GDV + LGP+ V + E + AL + Sbjct: 16 LQMDRGGFLNSFRRIREKYGDVFTVHLGPRPVVMLYGTEAIREALVDQAEAFSGRGTIAV 75 Query: 95 LEGLLGKEGVATANGPLHRRQRRTIQPAFRLDAI--PAYGPIMEEEAHALTERWQP--GK 150 +E + GV ANG + RR R + + ++EEA L E ++ G Sbjct: 76 VEPIFRGYGVVFANGERWKALRRFSLVTMRDFGMGKRSVEERIQEEARCLVEEFRKSQGA 135 Query: 151 TVDATSESFRVAVRVAARCLL--RGQYMDERAERLCVALATVFRGMYRR--MVVPLGPLY 206 +D T + + + R Y D + RL F + V L + Sbjct: 136 PLDPTFLFQCITANIICSIVFGERFDYKDHQFLRLLYLFYQSFSLISSFSSQVFELFSGF 195 Query: 207 RLPLPA-NRRFNDALADLHLLVDEIIAERRASGQK--PDDLLTALL----EAKDDNGDPI 259 P +R+ + L ++ + + + + RA+ P D + L + K + Sbjct: 196 LKYFPGTHRQISRNLQEILDYIGQSVEKHRATLDPSHPRDFIDTYLLRMEKEKSNQHTEF 255 Query: 260 GEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGG-RPVAFEDV 318 Q + V+++ G+ET ++T+ + + +P A++++ E++ V G R ED Sbjct: 256 DHQNLVISVLSLFFAGTETSSTTLRYGFLLMLKYPHVAEKVQKEIDQVIGSHRLPTLEDR 315 Query: 319 RKLRHTGNVIVEAMRLRPAVWV-LTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYD 377 K+ +T VI E R + + + + ++ GY +P ++ + DP+ ++ Sbjct: 316 TKMPYTEAVIYEIQRFSDLIPIGVPHKVTKDTLFRGYLLPKNTEVYPILSSALHDPQYFE 375 Query: 378 DNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVA 437 F+PD +L A A PFS GKR C + + +L L + + Sbjct: 376 QPDTFNPDHFLDANGALKKSEAFMPFSIGKRICLGEGIARNELFLFFTTILQNFSLSSPV 435 Query: 438 GSND 441 D Sbjct: 436 APKD 439 >3L4D-A nrPDB Length = 453 Score = 325 bits (834), Expect = 2e-89, Method: Composition-based stats. Identities = 94/444 (21%), Positives = 175/444 (39%), Gaps = 20/444 (4%) Query: 20 ELREPPVAGGGVPLLGHGWRLARDPLAFMSQLRD-HGDVVRIKLGPKTVYAVTNPELTGA 78 + + PPV G P +GH + +DPL FM + + +G + + + + V + Sbjct: 1 KGKLPPVVHGTTPFVGHIIQFGKDPLGFMLKAKKKYGGIFTMNICGNRITVVGDVHQHSK 60 Query: 79 LALNPDYHIAGP--LWESLEGLLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIME 136 P I P ++ + + G+ A P R Q + + + P ++ Sbjct: 61 F-FTPRNEILSPREVYSFMVPVFGEGVAYAAPYPRMREQLNFLAEELTVAKFQNFAPSIQ 119 Query: 137 EEAHALT-ERWQPGK-TVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGM 194 E W + ++ + + + A +CL R L Sbjct: 120 HEVRKFMKANWNKDEGEINILDDCSAMIINTACQCLFGEDLRKRLDARQFAQLLAKMESC 179 Query: 195 YRRMVVPLGPLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQKPD----DLLTALLE 250 V L + +LPLP + R DA A+L ++ EII R + D DLL LL Sbjct: 180 LIPAAVFLPWILKLPLPQSYRCRDARAELQDILSEIIIAREKEEAQKDTNTSDLLAGLLG 239 Query: 251 AKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALA--DHPEHADRIRDEVEAVT 308 A +G + + E+ +VA + G T T W L L + H ++ E++ Sbjct: 240 AVYRDGTRMSQHEVCGMIVAAMFAGQHTSTITTTWSLLHLMDPRNKRHLAKLHQEIDEFP 299 Query: 309 GGRPVAFEDVRK-LRHTGNVIVEAMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPY 367 + +++V + + E++R P + +L R+ + ++G Y +P G I SP Sbjct: 300 AQ--LNYDNVMEEMPFAEQCARESIRRDPPLVMLMRKVLKPVQVGKYVVPEGDIIACSPL 357 Query: 368 AIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAAL 427 +D +++ + E++P+R + A F AG KC + F + Q+ + A + Sbjct: 358 LSHQDEEAFPNPREWNPER-----NMKLVDGAFCGFGAGVHKCIGEKFGLLQVKTVLATV 412 Query: 428 ATKYRFEQVAGSNDAVRVGITLRP 451 Y FE + + + + P Sbjct: 413 LRDYDFELLGPLPEPNYHTMVVGP 436 >4WMZ-A nrPDB Length = 539 Score = 325 bits (834), Expect = 2e-89, Method: Composition-based stats. Identities = 92/477 (19%), Positives = 187/477 (39%), Gaps = 57/477 (11%) Query: 24 PPVAGGGVPLLGHGWRLARDPLAFMSQL-RDHGDVV---------RIKLGPKTVYAVTNP 73 PP+ +P +G P F + + +GD+ + LGPK V N Sbjct: 56 PPLVFYWIPWVGSAVVYGMKPYEFFEECQKKYGDIFSFVLLGRVMTVYLGPKGHEFVFNA 115 Query: 74 ELTGALALNPDYHIAGPLWESLEGLLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGP 133 +L A H+ P + GK + Q++ ++ A +A +Y P Sbjct: 116 KLADVSAEAAYAHLTTP-------VFGKGVIYDCPNSRLMEQKKFVKGALTKEAFKSYVP 168 Query: 134 IMEEEAHALTE-------RWQPGKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCVA 186 ++ EE + + T+D + + A+R LL + + Sbjct: 169 LIAEEVYKYFRDSKNFRLNERTTGTIDVMVTQPEMTIFTASRSLLGKEMRAKLDTDFAYL 228 Query: 187 LATVFRGMYRRMVVPLGPLY-RLPLPANRRFNDALADLHLLVDEIIAERRASGQKPD-DL 244 + + +G P+ ++ LPL R+ + A + +I ERR + D DL Sbjct: 229 YSDLDKGF-----TPINFVFPNLPLEHYRKRDHAQKAISGTYMSLIKERRKNNDIQDRDL 283 Query: 245 LTALLE-AKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDE 303 + +L++ + +G + +QEI + ++ +L G T A+T W+L LA+ P+ + +E Sbjct: 284 IDSLMKNSTYKDGVKMTDQEIANLLIGVLMGGQHTSAATSAWILLHLAERPDVQQELYEE 343 Query: 304 VEAVT--GGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESEL--GGYRIPAG 359 V G + + ++ ++++ I E +R+ + L R+ + + + Y IPAG Sbjct: 344 QMRVLDGGKKELTYDLLQEMPLLNQTIKETLRMHHPLHSLFRKVMKDMHVPNTSYVIPAG 403 Query: 360 ADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVP----------------KYAMKPF 403 ++ SP + + + +F+ RW + A++ PF Sbjct: 404 YHVLVSPGYTHLRDEYFPNAHQFNIHRWNNDSASSYSVGEEVDYGFGAISKGVSSPYLPF 463 Query: 404 SAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAG-----SNDAVRVGITLRPHDLL 455 G+ +C +HF+ QL ++ + ++ G + V + P ++ Sbjct: 464 GGGRHRCIGEHFAYCQLGVLMSIFIRTLKWHYPEGKTVPPPDFTSMVTLPTGPAKII 520 >2VE3-A nrPDB Length = 444 Score = 324 bits (830), Expect = 6e-89, Method: Composition-based stats. Identities = 109/433 (25%), Positives = 184/433 (42%), Gaps = 12/433 (2%) Query: 25 PVAGGGVPLLGHGWRLARDPLAFMSQLRDHGDVVRIKLGPKTVYAVTNPELTGALALNPD 84 P G+P LG D + + G + + +L K V ++ L + Sbjct: 14 PPGDFGLPWLGETLNFLNDGDFGKKRQQQFGPIFKTRLFGKNVIFISGA-LANRFLFTKE 72 Query: 85 YHIAGPLWE-SLEGLLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALT 143 W S LLG +AT G +HR +R+ + AF + +Y P M+ Sbjct: 73 QETFQATWPLSTRILLGPNALATQMGEIHRSRRKILYQAFLPRTLDSYLPKMDGIVQGYL 132 Query: 144 ERWQPGKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLG 203 E+W V + R+ VAA L G+ + + +L T +G++ + Sbjct: 133 EQWGKANEVIWYPQLRRMTFDVAA-TLFMGEKVSQNP-QLFPWFETYIQGLFSLPIP--- 187 Query: 204 PLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQE 263 LP + A A L +++II R+ +D L LL A+DDN P+ E Sbjct: 188 ----LPNTLFGKSQRARALLLAELEKIIKARQQQPPSEEDALGILLAARDDNNQPLSLPE 243 Query: 264 IHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRH 323 + DQ++ +L G ET+ S + L H + +R+R E + + + E ++K+ + Sbjct: 244 LKDQILLLLFAGHETLTSALSSFCLLLGQHSDIRERVRQEQNKLQLSQELTAETLKKMPY 303 Query: 324 TGNVIVEAMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFD 383 V+ E +RL P V R + + + G+ P G + Y DP Y D +FD Sbjct: 304 LDQVLQEVLRLIPPVGGGFRELIQDCQFQGFHFPKGWLVSYQISQTHADPDLYPDPEKFD 363 Query: 384 PDRWLPE-RAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDA 442 P+R+ P+ A + P +A PF G R+C F+ ++ L L ++ + + G N Sbjct: 364 PERFTPDGSATHNPPFAHVPFGGGLRECLGKEFARLEMKLFATRLIQQFDWTLLPGQNLE 423 Query: 443 VRVGITLRPHDLL 455 + V + RP D L Sbjct: 424 LVVTPSPRPKDNL 436 >4R20-A nrPDB Length = 486 Score = 323 bits (828), Expect = 9e-89, Method: Composition-based stats. Identities = 107/438 (24%), Positives = 183/438 (41%), Gaps = 20/438 (4%) Query: 44 PLAFMSQLRDHGDVVRIKLGPKTVYAVTNPELTGALALNPDYHIAGPLWESLEGLL--GK 101 L F +G + + GP V+ L + L AG LL G Sbjct: 42 HLLFTQLSSQYGPLFGLYAGPHLTLVVSEIGLVREVLLQRGREFAGRPKMVTTDLLTQGG 101 Query: 102 EGVATAN-GPLHRRQRRTIQPAFRL--DAIPAYGPIMEEEAHALTERWQP--GKTVDATS 156 + +A A+ PL + RR + +F L + I++E A +L E Q G++ D + Sbjct: 102 KDIAFADYSPLWKNHRRLVHSSFTLFGEGSNKLQTIVQEAADSLCEELQACRGQSSDLSV 161 Query: 157 ESFRVAVRVAARCLLRGQYMDERAERLCVALAT--VFRGMYRRMVVPLGPLYRL-PLPAN 213 R V R + Y E V + + + R +V + P R+ P Sbjct: 162 VLMRAVTNVICRLVFSSSYQPSDPELQTVIQYNDGIVQTIARGGLVDIFPWLRIFPNKDL 221 Query: 214 RRFNDALADLHLLVDEIIAERRASGQK--PDDLLTALLEAKDDNG---DPIGEQEIHDQV 268 +R + ++ L+ + + E + S P DLL ALL + D I E + Sbjct: 222 KRLKECVSIRDQLLYKKLLEHKKSLTPGEPRDLLDALLIGQQRGSGGADDITEDHVLMTA 281 Query: 269 VAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTG-GRPVAFEDVRKLRHTGNV 327 G ET ++T++W + L HP+ +R++ E++ G RP D L V Sbjct: 282 AEAFGAGVETTSTTLLWTIAFLLHHPQLQERVQAELDECVGVDRPPCLSDRPHLPLLDAV 341 Query: 328 IVEAMRLRPAVWVL-TRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDR 386 + E MR+RP +L A+ ++ LGG+ +P G ++ + +AI DPK +D +F+P+R Sbjct: 342 LCEVMRIRPVSPILIPHVAMQDTSLGGHSVPKGTRVLVNMWAIHHDPKHWDQPEQFNPER 401 Query: 387 WLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRF---EQVAGSNDAV 443 +L + + PF AG R C + + +L L + ++ F + + + Sbjct: 402 FLEPSGKKKTQSSFLPFGAGPRVCVGESLARIELFLFVSRPLQRFSFSCPSEASLPDLQG 461 Query: 444 RVGITLRPHDLLVRPVAR 461 R G+ L+P V R Sbjct: 462 RFGVVLQPERYTVTVTPR 479 >6CR2-A nrPDB Length = 477 Score = 318 bits (816), Expect = 2e-87, Method: Composition-based stats. Identities = 106/465 (22%), Positives = 177/465 (38%), Gaps = 42/465 (9%) Query: 22 REPPVAGGGVPLLGHGWRLARDPLAFMSQLR-DHGDVVRIKLGPKTVYAVTNPE-----L 75 + PPV P +G DP F R +GD+ L K + L Sbjct: 4 KTPPVVFHWFPFIGSTISYGIDPYKFFFDCRAKYGDIFTFILLGKKTTVYLGTKGNDFIL 63 Query: 76 TGALALNPDYHIAGPLWESLEGLLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIM 135 G L + PL + G+ V Q++ ++ DA+ +Y P++ Sbjct: 64 NGKLRDVCAEEVYSPL---TTPVFGRHVVYDCPNAKLMEQKKFVKYGLTSDALRSYVPLI 120 Query: 136 EEEAHALTERWQP----GKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVF 191 +E + + D + + A+R L + + + Sbjct: 121 TDEVESFVKNSPAFQGHKGVFDVCKTIAEITIYTASRSLQGKEVRSKFDSTFAELYHNLD 180 Query: 192 RGMYRRMVVPLGPLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQKPD--DLLTALL 249 G L PLP NR+ + A L EII RR +G K D D++ L+ Sbjct: 181 MGFAPI----NFMLPWAPLPHNRKRDAAQRKLTETYMEIIKARRQAGSKKDSEDMVWNLM 236 Query: 250 EAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTG 309 NG P+ ++EI ++A+L G + +ST W++ LA P+ + + E V G Sbjct: 237 SCVYKNGTPVPDEEIAHMMIALLMAGQHSSSSTASWIVLRLATRPDIMEELYQEQIRVLG 296 Query: 310 GR--PVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESELGG--YRIPAGADIIYS 365 P+ +++++KL VI E +RL + + R + G Y IP +++ S Sbjct: 297 SDLPPLTYDNLQKLDLHAKVIKETLRLHAPIHSIIRAVKNPMAVDGTSYVIPTSHNVLSS 356 Query: 366 PYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYA----------------MKPFSAGKRK 409 P R + + + LE++P RW AA+ PF AG+ + Sbjct: 357 PGVTARSEEHFPNPLEWNPHRWDENIAASAEDDEKVDYGYGLVSKGTNSPYLPFGAGRHR 416 Query: 410 CPSDHFSMAQLTLITAALATKYRFEQVA---GSNDAVRVGITLRP 451 C + F+ QL ITA L +RF + G D + +P Sbjct: 417 CIGEQFAYLQLGTITAVLVRLFRFRNLPGVDGIPDTDYSSLFSKP 461 >2NNH-A nrPDB Length = 476 Score = 318 bits (816), Expect = 2e-87, Method: Composition-based stats. Identities = 86/451 (19%), Positives = 166/451 (36%), Gaps = 20/451 (4%) Query: 25 PVAGGGVPLLGHGWRLARDPL--AFMSQLRDHGDVVRIKLGPKTVYAVTNPELTGALALN 82 P +P++G+ ++ + +F + + +G V + G + E ++ Sbjct: 12 PPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPVFTVYFGMNPIVVFHGYEAVKEALID 71 Query: 83 PDYHIAGPLWESLEGLLGKE-GVATANGPLHRRQRRTIQPAFRLDAI--PAYGPIMEEEA 139 +G + + K G+ ++NG + RR R + + ++EEA Sbjct: 72 NGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIRRFSLTTLRNFGMGKRSIEDRVQEEA 131 Query: 140 HALTERWQPGKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMV 199 H L E + K C + Q + ++ + L F +R + Sbjct: 132 HCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTLMKRFNENFRILN 191 Query: 200 VPL------GPLYRLPLPA-NRRFNDALADLHLLVDEIIAERRASGQ--KPDDLLTALL- 249 P PL P + + +A + E + E +AS P D + L Sbjct: 192 SPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYIREKVKEHQASLDVNNPRDFIDCFLI 251 Query: 250 ---EAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEA 306 + KD+ + + V + G+ET ++T+ + L L HPE ++++E++ Sbjct: 252 KMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDH 311 Query: 307 VTG-GRPVAFEDVRKLRHTGNVIVEAMRLRPAVWV-LTRRAVAESELGGYRIPAGADIIY 364 V G R +D + +T V+ E R V + +++ Y IP G I+ Sbjct: 312 VIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMA 371 Query: 365 SPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLIT 424 ++ D K + + FDP +L + PFSAGKR C + + +L L Sbjct: 372 LLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAGEGLARMELFLFL 431 Query: 425 AALATKYRFEQVAGSNDAVRVGITLRPHDLL 455 + + + V + +T L Sbjct: 432 TTILQNFNLKSVDDLKNLNTTAVTKGIVSLP 462 >5JLC-A nrPDB Length = 515 Score = 317 bits (812), Expect = 8e-87, Method: Composition-based stats. Identities = 90/471 (19%), Positives = 175/471 (37%), Gaps = 57/471 (12%) Query: 24 PPVAGGGVPLLGHGWRLARDPLAFMSQL-RDHGDVV---------RIKLGPKTVYAVTNP 73 PP+ +P +G P F + +GD+ + LGPK + N Sbjct: 38 PPLVFYWIPWVGSAIPYGTKPYEFFEDCQKKYGDIFSFMLLGRIMTVYLGPKGHEFIFNA 97 Query: 74 ELTGALALNPDYHIAGPLWESLEGLLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGP 133 +L A H+ P + GK + Q++ ++ A +A Y P Sbjct: 98 KLADVSAEAAYSHLTTP-------VFGKGVIYDCPNHRLMEQKKFVKGALTKEAFVRYVP 150 Query: 134 IMEEEAHALTERWQP-------GKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCVA 186 ++ EE + + VD + + A+R LL + D+ Sbjct: 151 LIAEEIYKYFRNSKNFKINENNSGIVDVMVSQPEMTIFTASRSLLGKEMRDKLDTDFAYL 210 Query: 187 LATVFRGMYRRMVVPLGPLY-RLPLPANRRFNDALADLHLLVDEIIAERRASGQ-KPDDL 244 + + +G P+ ++ LPL R+ + A + +I ERR + DL Sbjct: 211 YSDLDKGF-----TPINFVFPNLPLEHYRKRDHAQQAISGTYMSLIKERREKNDIQNRDL 265 Query: 245 LTALLE-AKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDE 303 + L++ + +G + +QEI + ++ +L G T A+T W L LA+ P+ + + E Sbjct: 266 IDELMKNSTYKDGTKMTDQEIANLLIGVLMGGQHTSAATSAWCLLHLAERPDVQEELYQE 325 Query: 304 VEAVTGG--RPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESEL--GGYRIPAG 359 V + + ++D++ + +I E +RL + L R+ + + + Y +P Sbjct: 326 QMRVLNNDTKELTYDDLQNMPLLNQMIKETLRLHHPLHSLFRKVMRDVAIPNTSYVVPRD 385 Query: 360 ADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYA-----------------MKP 402 ++ SP + + EF+ RW + A++ P Sbjct: 386 YHVLVSPGYTHLQEEFFPKPNEFNIHRWDGDAASSSAAGGDEVDYGFGAISKGVSSPYLP 445 Query: 403 FSAGKRKCPSDHFSMAQLTLITAALAT----KYRFEQVAGSNDAVRVGITL 449 F G+ +C + F+ QL ++ + +Y E +TL Sbjct: 446 FGGGRHRCIGELFAYCQLGVLMSIFIRTMKWRYPTEGETVPPSDFTSMVTL 496 >3IBD-A nrPDB Length = 476 Score = 317 bits (811), Expect = 8e-87, Method: Composition-based stats. Identities = 84/414 (20%), Positives = 156/414 (37%), Gaps = 18/414 (4%) Query: 46 AFMSQLRDHGDVVRIKLGPKTVYAVTNPE-LTGALALNPDYHIAGPLWESLEGLLGKEGV 104 +F+ +GDV + LGP+ V + E + AL + ++ GV Sbjct: 35 SFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGV 94 Query: 105 ATANGPLHRRQRRTIQPAFRLDAI--PAYGPIMEEEAHALTERWQP--GKTVDATSESFR 160 ANG + RR R + + ++EEA L E + G +D T Sbjct: 95 IFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQS 154 Query: 161 VAVRVAARCLL--RGQYMDERAERLCVALATVFR---GMYRRMVVPLGPLYRLPLPANRR 215 + + + R Y D+ ++ F ++ ++ + A+R+ Sbjct: 155 ITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKHFPGAHRQ 214 Query: 216 FNDALADLHLLVDEIIAERRASGQK--PDDLLTALL----EAKDDNGDPIGEQEIHDQVV 269 L +++ + + + R + P DL+ L + K + Q ++ + Sbjct: 215 VYKNLQEINAYIGHSVEKHRETLDPSAPRDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTL 274 Query: 270 AILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTG-GRPVAFEDVRKLRHTGNVI 328 ++ G+ET ++T+ + + +P A+R+ E+E V G RP D K+ +T VI Sbjct: 275 SLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVI 334 Query: 329 VEAMRLRPAVWV-LTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRW 387 E R + + + + GY IP ++ DP ++ F+PD + Sbjct: 335 YEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHF 394 Query: 388 LPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSND 441 L A A PFS GKR C + + A+L L + + D Sbjct: 395 LDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPED 448 >2X2N-A nrPDB Length = 475 Score = 316 bits (809), Expect = 2e-86, Method: Composition-based stats. Identities = 103/444 (23%), Positives = 180/444 (40%), Gaps = 25/444 (5%) Query: 23 EPPVAGGGVPLLGHGWRLARDPLAFMSQLRD--HGDVVRIKLGPKTVYAVTNPELTGALA 80 +PPV VP+LGH + + PL FM + + + I + K V V +P Sbjct: 17 DPPVYPVTVPILGHIIQFGKSPLGFMQECKRQLKSGIFTINIVGKRVTIVGDPHEHSRFF 76 Query: 81 LNPDYHIAGP--LWESLEGLLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEE 138 L P + P ++ + + G+ A P R Q + + + P ++ E Sbjct: 77 L-PRNEVLSPREVYSFMVPVFGEGVAYAAPYPRMREQLNFLAEELTIAKFQNFVPAIQHE 135 Query: 139 AHA-LTERWQPGK-TVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYR 196 + W + ++ + + + A +CL R L Sbjct: 136 VRKFMAANWDKDEGEINLLEDCSTMIINTACQCLFGEDLRKRLDARRFAQLLAKMESSLI 195 Query: 197 RMVVPLGPLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQKPD----DLLTALLEAK 252 V L L +LPLP + R ++A +L ++ EII R+A+ D DLL+ LL A Sbjct: 196 PAAVFLPILLKLPLPQSARCHEARTELQKILSEIIIARKAAAVNKDSSTSDLLSGLLSAV 255 Query: 253 DDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHP---EHADRIRDEVEAVTG 309 +G P+ E+ +VA + G T + T W + L HP +H + +R E+E Sbjct: 256 YRDGTPMSLHEVCGMIVAAMFAGQHTSSITTTWSMLHLM-HPANVKHLEALRKEIEEFPA 314 Query: 310 GRPVAFEDVR-KLRHTGNVIVEAMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYA 368 + + +V ++ E++R P + +L R+ +A+ ++G Y +P G I SP Sbjct: 315 Q--LNYNNVMDEMPFAERCARESIRRDPPLLMLMRKVMADVKVGSYVVPKGDIIACSPLL 372 Query: 369 IQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALA 428 D +++ + +DP+R + A F AG KC F + Q+ I A Sbjct: 373 SHHDEEAFPEPRRWDPER------DEKVEGAFIGFGAGVHKCIGQKFGLLQVKTILATAF 426 Query: 429 TKYRFEQVAGS-NDAVRVGITLRP 451 Y F+ + D + + P Sbjct: 427 RSYDFQLLRDEVPDPDYHTMVVGP 450 >2PG7-A nrPDB Length = 476 Score = 315 bits (806), Expect = 3e-86, Method: Composition-based stats. Identities = 96/457 (21%), Positives = 185/457 (40%), Gaps = 30/457 (6%) Query: 25 PVAGGGVPLLGHGWRLARDPL--AFMSQLRDHGDVVRIKLGPKTVYAVTNPELTG-ALAL 81 P +P +G+ +L + + + M +G V I LGP+ V + + AL Sbjct: 12 PPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVD 71 Query: 82 NPDYHIAGPLWESLEGLLGKEGVATANGPLHRRQRRTIQPAFRLDAI--PAYGPIMEEEA 139 + + + + GV +NG ++ RR R + ++EEA Sbjct: 72 QAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIEERIQEEA 131 Query: 140 HALTE--RWQPGKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRR 197 L + R G +D T R V + + ++ + ++ ++L + G+++ Sbjct: 132 GFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRF--DYKDKEFLSLLRMMLGIFQF 189 Query: 198 MVVPLGPLY--------RLPLPANRRFNDALADLHLLVDEIIA--ERRASGQKPDDLLTA 247 G LY LP P + F L L + + + +R P D + + Sbjct: 190 TSTSTGQLYEMFSSVMKHLPGPQQQAF-QLLQGLEDFIAKKVEHNQRTLDPNSPRDFIDS 248 Query: 248 -LLEAKDDNGDPIGEQEIHDQVVA---ILTPGSETIASTIMWLLQALADHPEHADRIRDE 303 L+ +++ +P E + + V+ + G+ET+++T+ + L HPE ++ +E Sbjct: 249 FLIRMQEEEKNPNTEFYLKNLVMTTLQLFVGGTETVSTTLRYGFLLLMKHPEVEAKVHEE 308 Query: 304 VEAVTG-GRPVAFEDVRKLRHTGNVIVEAMRLRPAVWV-LTRRAVAESELGGYRIPAGAD 361 ++ V G R FED K+ + VI E R + + L RR +++ + +P G + Sbjct: 309 IDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTE 368 Query: 362 IIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLT 421 + ++ RDP + + +F+P +L E+ A PFS GKR C + + +L Sbjct: 369 VYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELF 428 Query: 422 LITAALATKYRFEQVAGSND----AVRVGITLRPHDL 454 L + +R + D VG P + Sbjct: 429 LFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNY 465 >5W0C-A nrPDB Length = 477 Score = 313 bits (803), Expect = 7e-86, Method: Composition-based stats. Identities = 84/444 (18%), Positives = 165/444 (37%), Gaps = 20/444 (4%) Query: 25 PVAGGGVPLLGHGWRLA-RDPLAFMSQLRD-HGDVVRIKLGPKTVYAVTNPELTGALALN 82 P +P++G+ ++ +D ++ L +G V + G K + + E ++ Sbjct: 13 PPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALID 72 Query: 83 -PDYHIAGPLWESLEGLLGKEGVATANGPLHRRQRRTIQPAFRLDAI--PAYGPIMEEEA 139 + ++ E G+ +NG + RR R + + ++EEA Sbjct: 73 LGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEA 132 Query: 140 HALTERWQPGK--TVDATSESFRVAVRVAARCLL--RGQYMDERAERLCVALAT---VFR 192 L E + K D T V + R Y D++ L L + Sbjct: 133 RCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILS 192 Query: 193 GMYRRMVVPLGPLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQ--KPDDLLTALL- 249 + ++ P+ + + +A + + E + E + S P D + L Sbjct: 193 SPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLM 252 Query: 250 ---EAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEA 306 + K + + + + V + G+ET ++T+ + L L HPE ++++E+E Sbjct: 253 KMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIER 312 Query: 307 VTG-GRPVAFEDVRKLRHTGNVIVEAMRLRPAVWV-LTRRAVAESELGGYRIPAGADIIY 364 V G R +D + +T V+ E R + L + + Y IP G I+ Sbjct: 313 VIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILI 372 Query: 365 SPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLIT 424 S ++ D K + + FDP +L E PFSAGKR C + + +L L Sbjct: 373 SLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFL 432 Query: 425 AALATKYRFEQVAGSNDAVRVGIT 448 ++ + + + + + Sbjct: 433 TSILQNFNLKSLVDPKNLDTTPVV 456 >3E6I-A nrPDB Length = 476 Score = 310 bits (793), Expect = 1e-84, Method: Composition-based stats. Identities = 94/443 (21%), Positives = 172/443 (38%), Gaps = 33/443 (7%) Query: 25 PVAGGGVPLLGHG--WRLARDPLAFMSQLRDHGDVVRIKLGPKTVYAVTNPELTGALALN 82 P +P++G+ L P +F + G V + +G + + + + L+ Sbjct: 12 PPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLD 71 Query: 83 PDYHIAGPLWESLEGLLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAY-------GPIM 135 +G G+ NGP + RR F L + Y + Sbjct: 72 YKDEFSGRGDLPAFHAHRDRGIIFNNGPTWKDIRR-----FSLTTLRNYGMGKQGNESRI 126 Query: 136 EEEAHALTERWQP--GKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRG 193 + EAH L E + G+ D T V A L R + + + + L +F Sbjct: 127 QREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHF--DYNDEKFLRLMYLFNE 184 Query: 194 MYRRMVVPLGPLYRLPL-------PANRRFNDALADLHLLVDEIIAERRASGQK--PDDL 244 + + P LY ++R+ +A++ V E + E S P DL Sbjct: 185 NFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDL 244 Query: 245 LTALL---EAKDDNGDPI-GEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRI 300 LL E + + + + I V + G+ET ++T+ + L L +PE +++ Sbjct: 245 TDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKL 304 Query: 301 RDEVEAVTG-GRPVAFEDVRKLRHTGNVIVEAMRLRPAVWV-LTRRAVAESELGGYRIPA 358 +E++ V G R A +D +++ + V+ E R V L A ++ GY IP Sbjct: 305 HEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPK 364 Query: 359 GADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMA 418 G ++ + ++ D + + D +F P+ +L E KPFS GKR C + + Sbjct: 365 GTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARM 424 Query: 419 QLTLITAALATKYRFEQVAGSND 441 +L L+ A+ + + + D Sbjct: 425 ELFLLLCAILQHFNLKPLVDPKD 447 >1N6B-A nrPDB Length = 473 Score = 309 bits (792), Expect = 1e-84, Method: Composition-based stats. Identities = 90/434 (20%), Positives = 162/434 (37%), Gaps = 17/434 (3%) Query: 25 PVAGGGVPLLGHGWRLARDPLA--FMSQLRDHGDVVRIKLGPKTVYAVTNPELTGALALN 82 P P++G+ ++ ++ +G V + LG K + E ++ Sbjct: 12 PPGPTPFPIIGNILQIDAKDISKSLTKFSECYGPVFTVYLGMKPTVVLHGYEAVKEALVD 71 Query: 83 PDYHIAGP-LWESLEGLLGKEGVATANGPLHRRQRRTIQPAFRLDAI--PAYGPIMEEEA 139 AG LE + G+A +N + RR R + + ++EEA Sbjct: 72 LGEEFAGRGSVPILEKVSKGLGIAFSNAKTWKEMRRFSLMTLRNFGMGKRSIEDRIQEEA 131 Query: 140 HALTERWQP--GKTVDATSESFRVAVRVAARCLL--RGQYMDERAERLCVALAT---VFR 192 L E + D T V + R Y DE +L +L + Sbjct: 132 RCLVEELRKTNASPCDPTFILGCAPCNVICSVIFHNRFDYKDEEFLKLMESLHENVELLG 191 Query: 193 GMYRRMVVPLGPLYRLPLPANRRFNDALADLHLLVDEIIAERRA--SGQKPDDLLTA-LL 249 + ++ L ++ + + E + E + P D + L+ Sbjct: 192 TPWLQVYNNFPALLDYFPGIHKTLLKNADYIKNFIMEKVKEHQKLLDVNNPRDFIDCFLI 251 Query: 250 EAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTG 309 + + +N + + V + G+ET ++T+ + L L HPE A R+++E+E V G Sbjct: 252 KMEQENNLEFTLESLVIAVSDLFGAGTETTSTTLRYSLLLLLKHPEVAARVQEEIERVIG 311 Query: 310 -GRPVAFEDVRKLRHTGNVIVEAMRLRPAVWV-LTRRAVAESELGGYRIPAGADIIYSPY 367 R +D ++ +T VI E R + L + Y IP G DII S Sbjct: 312 RHRSPCMQDRSRMPYTDAVIHEIQRFIDLLPTNLPHAVTRDVRFRNYFIPKGTDIITSLT 371 Query: 368 AIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAAL 427 ++ D K++ + FDP +L E PFSAGKR C + + +L L ++ Sbjct: 372 SVLHDEKAFPNPKVFDPGHFLDESGNFKKSDYFMPFSAGKRMCVGEGLARMELFLFLTSI 431 Query: 428 ATKYRFEQVAGSND 441 ++ + + D Sbjct: 432 LQNFKLQSLVEPKD 445 >5FSA-A nrPDB Length = 490 Score = 309 bits (791), Expect = 2e-84, Method: Composition-based stats. Identities = 98/480 (20%), Positives = 169/480 (35%), Gaps = 63/480 (13%) Query: 22 REPPVAGGGVPLLGHGWRLARDPLAFMSQLR-DHGDVV---------RIKLGPKTVYAVT 71 + PP+ +P G + P F R +GDV + LGPK V Sbjct: 4 KTPPLVFYWIPWFGSAASYGQQPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGHEFVF 63 Query: 72 NPELTGALALNPDYHIAGPLWESLEGLLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAY 131 N +L+ A H+ P + G + Q++ + A D+ Y Sbjct: 64 NAKLSDVSAEEAYKHLTTP-------VFGTGVIYDCPNSRLMEQKKFAKFALTTDSFKRY 116 Query: 132 GPIMEEEA-------HALTERWQPGKTVDATSESFRVAVRVAARCLLRGQYMDERAERLC 184 P + EE + + + + + + A+R L + Sbjct: 117 VPKIREEILNYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFA 176 Query: 185 VALATVFRGMYRRMVVPLGPLY-RLPLPANRRFNDALADLHLLVDEIIAERRASGQ--KP 241 + + +G P+ ++ LPLP R + A + + I RR G Sbjct: 177 QLYSDLDKGF-----TPINFVFPNLPLPHYWRRDAAQKKISATYMKEIKLRRERGDIDPN 231 Query: 242 DDLLTAL-LEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRI 300 DL+ +L + + +G + +QEI + ++ IL G T AST W L L + P D I Sbjct: 232 RDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVI 291 Query: 301 RDEVEAVTGGR-----PVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESEL--GG 353 EV + + + +ED++KL N I E +R+ + + R+ + Sbjct: 292 YQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETN 351 Query: 354 YRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAA-------------------- 393 Y +P G ++ SP + +D+ +FDP RW A Sbjct: 352 YIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVS 411 Query: 394 NVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGS--NDAVRVGITLRP 451 PF G+ +C + F+ QL I R+ + G D + + P Sbjct: 412 KGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRW-TIDGYKVPDPDYSSMVVLP 470 >4GQS-A nrPDB Length = 477 Score = 308 bits (788), Expect = 4e-84, Method: Composition-based stats. Identities = 85/444 (19%), Positives = 162/444 (36%), Gaps = 20/444 (4%) Query: 25 PVAGGGVPLLGHGWRLA-RDPLAFMSQLRD-HGDVVRIKLGPKTVYAVTNPELTGALALN 82 P +P++G+ ++ +D ++ L +G V + G + + + E+ ++ Sbjct: 13 PPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALID 72 Query: 83 -PDYHIAGPLWESLEGLLGKEGVATANGPLHRRQRRTIQPAFRLDAI--PAYGPIMEEEA 139 + + E G+ +NG + RR R + + ++EEA Sbjct: 73 LGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEA 132 Query: 140 HALTERWQPGK--TVDATSESFRVAVRVAARCLL--RGQYMDERAERLCVALATVFR--- 192 L E + K D T V + R Y D++ L L R Sbjct: 133 RCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVS 192 Query: 193 GMYRRMVVPLGPLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQ--KPDDLLTALL- 249 + ++ + + + LA + + E + E + S P D + L Sbjct: 193 TPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLI 252 Query: 250 ---EAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEA 306 + K + + + +L G+ET ++T+ + L L HPE ++++E+E Sbjct: 253 KMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIER 312 Query: 307 VTG-GRPVAFEDVRKLRHTGNVIVEAMRLRPAVWV-LTRRAVAESELGGYRIPAGADIIY 364 V G R +D + +T V+ E R + L + + Y IP G I+ Sbjct: 313 VVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILT 372 Query: 365 SPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLIT 424 S ++ D K + + FDP +L E PFSAGKR C + + +L L Sbjct: 373 SLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFL 432 Query: 425 AALATKYRFEQVAGSNDAVRVGIT 448 + + + + D + Sbjct: 433 TFILQNFNLKSLIDPKDLDTTPVV 456 >4R1Z-A nrPDB Length = 439 Score = 304 bits (778), Expect = 5e-83, Method: Composition-based stats. Identities = 88/427 (20%), Positives = 162/427 (37%), Gaps = 27/427 (6%) Query: 62 LGPKTVYAVTNPELTGALALNPDYHIAGPLWESLEGLLGKEG--VATANGP-LHRRQRRT 118 +G + V N + + AG LL ++G +A A+ + R+ Sbjct: 1 MGSHKLLIVNNHHHAKEILIKKGKIFAGRPRTVTTDLLTRDGKDIAFADYSSTWKFHRKM 60 Query: 119 IQPAFRL--DAIPAYGPIMEEEAHALTERWQPGK--TVDATSESFRVAVRVAARCLLRGQ 174 + A + + + I+ EA ++ E + VD E R V Sbjct: 61 VHGALCMFGEGSVSIEKIICREASSMCEVLTESQNSAVDLGPELTRAVTNVVCALCFNSS 120 Query: 175 YM--DERAERLCVALATVFRGMYRRMVVPLGPLYR-LPLPANRRFNDALADLHLLVDEII 231 Y D E + + + + +V + P + P ++ L+ + Sbjct: 121 YKRGDAEFESMLQYSQGIVDTVAKDSLVDIFPWLQIFPNKDLTILRQCISIRDKLLQKKY 180 Query: 232 AERRASGQK--PDDLLTALLEAKDDNGDP--------IGEQEIHDQVVAILTPGSETIAS 281 E + + DLL ALL AK + + + E + V I G ET + Sbjct: 181 EEHKVTYSDNVQRDLLDALLRAKRSSENNNSSTRDVGLTEDHVLMTVGDIFGAGVETTTT 240 Query: 282 TIMWLLQALADHPEHADRIRDEVEAVTG-GRPVAFEDVRKLRHTGNVIVEAMRLRPAVWV 340 + W + L +P+ +I++E+++ G R D L + I E +R+RP + Sbjct: 241 VLKWSIAYLVHNPQVQRKIQEELDSKIGKERHPQLSDRGNLPYLEATIREVLRIRPVSPL 300 Query: 341 L-TRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANV--PK 397 L A+ +S +G Y + G ++ + +++ D K + + FDP R+L E + P Sbjct: 301 LIPHVALQDSSVGEYTVQKGTRVVINLWSLHHDKKEWKNPELFDPGRFLNEEGDGLCCPS 360 Query: 398 YAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDA---VRVGITLRPHDL 454 + PF AG R C + + +L L A + ++ E G + G+ L+P Sbjct: 361 GSYLPFGAGVRVCLGEALAKMELFLFLAWILQRFTLEMPTGQPLPDLQGKFGVVLQPKKF 420 Query: 455 LVRPVAR 461 V R Sbjct: 421 KVVAKVR 427 >6DA2-A nrPDB Length = 487 Score = 297 bits (760), Expect = 6e-81, Method: Composition-based stats. Identities = 89/456 (19%), Positives = 174/456 (38%), Gaps = 23/456 (5%) Query: 26 VAGGGVPLLGHGWRLARDPLAFMSQL-RDHGDVVRIKLGPKTVYAVTNPELTGALALNPD 84 +P LG+ + F + + +G V G + V A+T+P++ + + Sbjct: 19 PGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKEC 78 Query: 85 YHIAGPLWESLEGLLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTE 144 Y + K ++ A +R R + P F + PI+ + L Sbjct: 79 YSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVR 138 Query: 145 RW----QPGKTVDATSESFRVAVRVAARCLL------RGQYMDERAERLCVALATVFRGM 194 + GK V ++ V D E L F Sbjct: 139 NLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDP 198 Query: 195 YRRMVVPLGPLYRLPLPANRRF---NDALADLHLLVDEIIAERRASGQKPD-DLLTALLE 250 + + + + P L + L V + R QK D L +++ Sbjct: 199 F-FLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMID 257 Query: 251 AKD----DNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEA 306 +++ ++ + + E+ Q + + G ET +S + +++ LA HP+ ++++E++A Sbjct: 258 SQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDA 317 Query: 307 V-TGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYS 365 V P ++ V ++ + V+ E +RL P L R + E+ G IP G ++ Sbjct: 318 VLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIP 377 Query: 366 PYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITA 425 YA+ RDPK + + +F P+R+ + N+ Y PF +G R C F++ + L Sbjct: 378 SYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALI 437 Query: 426 ALATKYRFEQ--VAGSNDAVRVGITLRPHDLLVRPV 459 + + F+ + +G L+P +V V Sbjct: 438 RVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKV 473 >6DWN-A nrPDB Length = 491 Score = 296 bits (758), Expect = 1e-80, Method: Composition-based stats. Identities = 100/450 (22%), Positives = 180/450 (40%), Gaps = 33/450 (7%) Query: 21 LREPPVAGGGVPLLGHGWRLARDPL-AFMSQLRDHGDVVRIKLGPKTVYAVTNPE-LTGA 78 L+ PP G PL+GH L ++P A + +GDV++I++G V ++ + + A Sbjct: 10 LKNPP-GPWGWPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQA 68 Query: 79 LALNPDYHIAGPLWESLEGLLGKEGVATAN--GPLHRRQRRTIQ---PAFRLDAIPA--- 130 L D P + + + ++ + GP+ +RR Q +F + + PA Sbjct: 69 LVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASST 128 Query: 131 ---YGPIMEEEAHALTERWQ-----PGKTVDATSESFRVAVRVAARCLLRGQYMDERAER 182 + +EA L Q PG V + A C R + + Sbjct: 129 SCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELL 188 Query: 183 LCVALATVFRGMYRRMV-VPLGPLYR-LPLPANRRFNDALADLHLLVDEIIAERRASGQK 240 V L F + P+ R LP P+ F D + + +++ E + +K Sbjct: 189 SLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEK 248 Query: 241 P--DDLLTALLEA------KDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALAD 292 D+ +L+E ++ + +++I + V+ + G +T+ + I W L L Sbjct: 249 GHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVM 308 Query: 293 HPEHADRIRDEVEAVTG-GRPVAFEDVRKLRHTGNVIVEAMRLRPAVW-VLTRRAVAESE 350 +P +I++E++ V G R D L + I+E R V + ++ Sbjct: 309 NPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTS 368 Query: 351 LGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAA--NVPKYAMKPFSAGKR 408 L G+ IP G + + + I D K + + EF P+R+L A V + F GKR Sbjct: 369 LKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKR 428 Query: 409 KCPSDHFSMAQLTLITAALATKYRFEQVAG 438 KC + + ++ L A L + F G Sbjct: 429 KCIGETIARWEVFLFLAILLQRVEFSVPLG 458 >5VEU-A nrPDB Length = 480 Score = 296 bits (757), Expect = 2e-80, Method: Composition-based stats. Identities = 89/455 (19%), Positives = 172/455 (37%), Gaps = 22/455 (4%) Query: 26 VAGGGVPLLGHGWRLARDPLAFMSQL-RDHGDVVRIKLGPKTVYAVTNPELTGALALNPD 84 +PLLG+ + F ++ + +G + G V A+T+P++ + + Sbjct: 18 PGPTPLPLLGNVLSYRQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKEC 77 Query: 85 YHIAGPLWESLEGLLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTE 144 Y + K ++ A +R R + P F + PI+ + L Sbjct: 78 YSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVR 137 Query: 145 RW----QPGKTVDATSESFRVAVRVAARCLL------RGQYMDERAERLCVALATVFRGM 194 + GK V ++ V D E L F Sbjct: 138 NLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDP 197 Query: 195 YRRMVVPLGPLYRLPLPANRRF--NDALADLHLLVDEIIAERRASGQKPD-DLLTALLEA 251 ++ L + N D + L V+ + R QK D L ++++ Sbjct: 198 LFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDS 257 Query: 252 KD----DNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAV 307 ++ ++ + + E+ Q + + G ET +S + + L LA HP+ +++ E++AV Sbjct: 258 QNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAV 317 Query: 308 -TGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSP 366 P ++ V ++ + V+ E +RL P L R + E+ G IP G+ ++ Sbjct: 318 LPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPT 377 Query: 367 YAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAA 426 YA+ DPK + + EF P+R+ ++ ++ Y PF G R C F++ + L Sbjct: 378 YALHHDPKYWTEPEEFRPERFS-KKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIR 436 Query: 427 LATKYRFEQ--VAGSNDAVRVGITLRPHDLLVRPV 459 + + F+ + L+P +V V Sbjct: 437 VLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKV 471 >5UYS-A nrPDB Length = 494 Score = 294 bits (752), Expect = 5e-80, Method: Composition-based stats. Identities = 93/469 (19%), Positives = 180/469 (38%), Gaps = 32/469 (6%) Query: 25 PVAGGGVPLLGHGW---RLARDPLAFMSQLRDHGDVVRIKLGPKTVYAVTNPELTGALAL 81 P + +PL+G R F + +G + +++G KT V + +L + + Sbjct: 10 PKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLI 69 Query: 82 NPDY-HIAGPLWESLEGL-LGKEGVATAN-GPLHRRQRRTIQPAFRL--DAIPAYGPIME 136 P +L+ ++G+A A+ G + RR F L D I+ Sbjct: 70 KKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIIC 129 Query: 137 EEAHALTERWQ--PGKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALAT--VFR 192 +E L + G+++D + F V + Y + E + + Sbjct: 130 QEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIID 189 Query: 193 GMYRRMVVPLGPLYR-LPLPANRRFNDALADLHLLVDEIIAERRASGQKPD--DLLTALL 249 + + +V L P + P + + + L+++I+ + + ++L L+ Sbjct: 190 NLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLM 249 Query: 250 EAK----------DDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADR 299 +AK D + + + + I + I G ET S + W L L +P+ + Sbjct: 250 QAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKK 309 Query: 300 IRDEVEAVTG-GRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVL-TRRAVAESELGGYRIP 357 + +E++ G R D +L I E +RLRP +L +A +S +G + + Sbjct: 310 LYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVD 369 Query: 358 AGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANV--PKYAMKPFSAGKRKCPSDHF 415 G ++I + +A+ + K + +F P+R+L + P + PF AG R C + Sbjct: 370 KGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEIL 429 Query: 416 SMAQLTLITAALATKYRFEQVAGSNDAVRVGI---TLRPHDLLVRPVAR 461 + +L LI A L ++ E GI V+ R Sbjct: 430 ARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIKVR 478 >2W0A-A nrPDB Length = 455 Score = 292 bits (748), Expect = 2e-79, Method: Composition-based stats. Identities = 104/429 (24%), Positives = 183/429 (42%), Gaps = 15/429 (3%) Query: 25 PVAGGGVPLLGHGWRLARDPLAFMSQLRDH-GDVVRIKLGPKTVYAVTNPELTGALALNP 83 P GG GH DP+ M ++RD GDV +L K V ++ Sbjct: 7 PRVSGGHDEHGHLEEFRTDPIGLMQRVRDELGDVGTFQLAGKQVVLLSGSHANEFFFRAG 66 Query: 84 DYHIAGPL-WESLEGLLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHAL 142 D + + + + G+ V A+ + A R + + + +E++ + Sbjct: 67 DDDLDQAKAYPFMTPIFGEAVVFDASPERRKE--MLHNAALRGEQMKGHAATIEDQVRRM 124 Query: 143 TERWQPGKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPL 202 W +D + + ++ CL+ ++ D+ R + RG V Sbjct: 125 IADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLAYVDP 184 Query: 203 GPLYRLPLPANRRFNDALADLHLLVDEIIAERRASG---QKPDDLLTALLEAKDDNGDP- 258 LP+ + RR ++A L LV +I+ R A+ + D+L L+ K + G P Sbjct: 185 ----YLPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPR 240 Query: 259 IGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTG-GRPVAFED 317 EI ++++ G T + T W L L H + + DE++ + G GR V+F Sbjct: 241 FSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFHA 300 Query: 318 VRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYD 377 +R++ NV+ E +RL P + +L R A E E+ G+RI G + SP R P+ + Sbjct: 301 LRQIPQLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFP 360 Query: 378 DNLEFDPDRW-LPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQV 436 D +F P R+ P + + ++ PF AG+ +C F++ Q+ I + L +Y FE Sbjct: 361 DPHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEM- 419 Query: 437 AGSNDAVRV 445 A ++ R Sbjct: 420 AQPPESYRN 428 >2HI4-A nrPDB Length = 495 Score = 290 bits (743), Expect = 7e-79, Method: Composition-based stats. Identities = 101/455 (22%), Positives = 180/455 (39%), Gaps = 33/455 (7%) Query: 16 PGAPELREPPVAGGGVPLLGHGWRLARDPL-AFMSQLRDHGDVVRIKLGPKTVYAVTNPE 74 P P+ + P G PLLGH L ++P A + +GDV++I++G V ++ + Sbjct: 9 PRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLD 68 Query: 75 -LTGALALNPDYHIAGPLWESLEGLLGKEGVATA--NGPLHRRQRRTIQPA---FRLDAI 128 + AL D P + + + + + +GP+ +RR Q A F + + Sbjct: 69 TIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASD 128 Query: 129 PA------YGPIMEEEAHALTERWQP----GKTVDATSESFRVAVRVAARCLLRGQYMDE 178 PA + +EA AL R Q D ++ V GQ+ E Sbjct: 129 PASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCF-GQHFPE 187 Query: 179 RAERLCVALATVFRGMYRRMV---VPLGPLYR-LPLPANRRFNDALADLHLLVDEIIAER 234 ++ + + + + P+ R LP PA +RF + + + E Sbjct: 188 SSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEH 247 Query: 235 RASGQKP--DDLLTALLEAKDD----NGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQ 288 K D+ AL + +G+ I +++I + V I G +T+ + I W L Sbjct: 248 YQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLM 307 Query: 289 ALADHPEHADRIRDEVEAVTG-GRPVAFEDVRKLRHTGNVIVEAMRLRPAVW-VLTRRAV 346 L PE +I+ E++ V G R D +L + I+E R + + Sbjct: 308 YLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTT 367 Query: 347 AESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVP---KYAMKPF 403 ++ L G+ IP + + + + DP+ ++D EF P+R+L + M F Sbjct: 368 RDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLF 427 Query: 404 SAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAG 438 GKR+C + + ++ L A L + F G Sbjct: 428 GMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPG 462 >5YLW-A nrPDB Length = 495 Score = 288 bits (736), Expect = 4e-78, Method: Composition-based stats. Identities = 99/438 (22%), Positives = 185/438 (42%), Gaps = 25/438 (5%) Query: 22 REPPVAGGGVPLLGHGWRLARDPLAFMSQL-RDHGDVVRIKLGPKTVYAVTNPELTGALA 80 R P P++G+ +L +P ++L + +G ++ I LG V++PE+ + Sbjct: 26 RNLPPGPFPYPIVGNMLQLGANPHQVFAKLSKRYGPLMSIHLGSLYTVIVSSPEMAKEIL 85 Query: 81 LNPDYHIAGPLWESLEGLLGKEGVATANGP---LHRRQRRTIQ-PAFRLDAIPAYGPIME 136 +G + ++ P R R+ + F ++ A + Sbjct: 86 HRHGQVFSGRTIAQAVHACDHDKISMGFLPVASEWRDMRKICKEQMFSNQSMEASQGLRR 145 Query: 137 EEAHALTERWQP----GKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFR 192 ++ L + Q G+ VD +F + + + L Q E + + + Sbjct: 146 QKLQQLLDHVQKCSDSGRAVDIREAAFITTLNLMSATLFSSQ-ATEFDSKATMEFKEIIE 204 Query: 193 GMYRRMVVP----LGPLYRLPLPANRR------FNDALADLHLLVDEIIAERRASGQKP- 241 G+ + VP P+ R P + F LA + ++E + +RA+ P Sbjct: 205 GVATIVGVPNFADYFPILRPFDPQGVKRRADVFFGKLLAKIEGYLNERLESKRANPNAPK 264 Query: 242 -DDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRI 300 DD L +++ N + ++ + GS+T ++I W + L +P+ R+ Sbjct: 265 KDDFLEIVVDIIQANEFKLKTHHFTHLMLDLFVGGSDTNTTSIEWAMSELVMNPDKMARL 324 Query: 301 RDEVEAVTGGRPVAFE-DVRKLRHTGNVIVEAMRLRPAVWVL-TRRAVAESELGGYRIPA 358 + E+++V G + E + KL + VI E MR+ P +L R+A ++ E+ GY IP Sbjct: 325 KAELKSVAGDEKIVDESAMPKLPYLQAVIKEVMRIHPPGPLLLPRKAESDQEVNGYLIPK 384 Query: 359 GADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANV-PKYAMKPFSAGKRKCPSDHFSM 417 G I+ + YAI RDP + D FDP+R+L + Y + PF +G+R CP + Sbjct: 385 GTQILINAYAIGRDPSIWTDPETFDPERFLDNKIDFKGQDYELLPFGSGRRVCPGMPLAT 444 Query: 418 AQLTLITAALATKYRFEQ 435 L + TA L + ++ Sbjct: 445 RILHMATATLVHNFDWKL 462 >5CJE-A nrPDB Length = 393 Score = 285 bits (728), Expect = 3e-77, Method: Composition-based stats. Identities = 94/440 (21%), Positives = 152/440 (34%), Gaps = 59/440 (13%) Query: 28 GGGVPLLGHGWRLARDPLAFMSQLRDHGDVVRIKLGPKTV---YAVTNPELTGALALNPD 84 G + L +G R DP ++LR+ G V ++ P + V E A +P Sbjct: 2 GNVIDLGEYGARFTEDPYPVYAELRERGPVHWVRTPPPEAFEGWLVVGHEEARAALADPR 61 Query: 85 YHIAG--PLWESLEGLLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHAL 142 G SL+ L + + P H R R + AF + + A P ++E L Sbjct: 62 LSKDGTKKGLTSLDVELMGPYLLVVDPPEHTRLRSLVARAFTMRRVEALRPRIQEITDGL 121 Query: 143 TERWQPGKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPL 202 + P D +SF + + C L G +R FR + +V P Sbjct: 122 LDEMLPRGRADLV-DSFAYPLPITVICELLGVPDIDRV---------TFRALSNEIVAPT 171 Query: 203 GPLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQ 262 G L A L +DE+I ++R++ DDLL L+ + ++ D + + Sbjct: 172 GGDAEL---------AAYERLAAYLDELIDDKRSTA-PADDLLGDLIRTRAEDDDRLSGE 221 Query: 263 EIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLR 322 E+ +L G ET + I + L HP+ +R + + Sbjct: 222 ELRAMAFILLVAGHETTVNLITNGVHTLLTHPDQLAALRAD-----------------MT 264 Query: 323 HTGNVIVEAMRLRPAVWV-LTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLE 381 + E +R V R A E+GG I G ++ A RDP + D Sbjct: 265 LLDGAVEEVLRFEGPVETATYRYAAESMEIGGTAIAEGDPVMIGLDAAGRDPARHPDPHV 324 Query: 382 FDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSND 441 FD R F G C + + + +L + + G Sbjct: 325 FDIHR---------APQGHLAFGHGIHYCLGAPLARLEARVALRSLLERCPDLALDGPP- 374 Query: 442 AVRVGITLRPHDLLVRPVAR 461 RP +L+R V R Sbjct: 375 ------GARPPGMLIRGVRR 388 >3EJB-B nrPDB Length = 404 Score = 283 bits (723), Expect = 1e-76, Method: Composition-based stats. Identities = 76/405 (18%), Positives = 140/405 (34%), Gaps = 49/405 (12%) Query: 39 RLARDPLAFMSQLRDHGDVVRIKLGPKTVYAVTNPELTGALALNPDYHIAGPLWESLEGL 98 ++P +F LR + + + VT E T A+ + + + PL ES Sbjct: 10 EFLKNPYSFYDTLRAVHPIYKGSFLKYPGWYVTGYEETAAILKDARFKVRTPLPESSTKY 69 Query: 99 -----LGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVD 153 + + + N P HRR R AF +Y P + E H L ++ Q K ++ Sbjct: 70 QDLSHVQNQMMLFQNQPDHRRLRTLASGAFTPRTTESYQPYIIETVHHLLDQVQGKKKME 129 Query: 154 ATSES-FRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPA 212 S+ F +A V A + + E+ + +L R + G + + Sbjct: 130 VISDFAFPLASFVIANIIGVPEEDREQLKEWAASLIQTIDFTRSRKALTEGNIMAV---- 185 Query: 213 NRRFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAIL 272 E+I +R+ Q+ D+++ LL+ ++ D + E+E + + Sbjct: 186 ---------QAMAYFKELIQKRKRHPQQ--DMISMLLKGREK--DKLTEEEAASTCILLA 232 Query: 273 TPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAM 332 G ET + I + L HPE ++R+ + + G + E + Sbjct: 233 IAGHETTVNLISNSVLCLLQHPEQLLKLRENPDLI-----------------GTAVEECL 275 Query: 333 RLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERA 392 R + R A + ++ G I G + A RDP + + FD R Sbjct: 276 RYESPTQMTARVASEDIDICGVTIRQGEQVYLLLGAANRDPSIFTNPDVFDITR------ 329 Query: 393 ANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVA 437 F G C + + + L + +A Sbjct: 330 ---SPNPHLSFGHGHHVCLGSSLARLEAQIAINTLLQRMPSLNLA 371 >4KPA-A nrPDB Length = 494 Score = 279 bits (714), Expect = 2e-75, Method: Composition-based stats. Identities = 93/426 (21%), Positives = 193/426 (45%), Gaps = 12/426 (2%) Query: 46 AFMSQLRDHGDVVRIKLGPKTVYAVTNPELTGALALNPDYHIAGPLWESLEGLLGKEGVA 105 A M + G++ + + + +++ L + +G+ Sbjct: 52 ALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLF 111 Query: 106 TANG--PLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQ---PGKTVDATSESFR 160 T+ ++ + P+F A+ Y +M + A L ++W+ + ++ + R Sbjct: 112 TSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTR 171 Query: 161 VAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPL--PANRRFND 218 + + C ++ ++ + ++ R + M P R+F + Sbjct: 172 LTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQE 231 Query: 219 ALADLHLLVDEIIAERRASGQKPDDLLTALLEAKD-DNGDPIGEQEIHDQVVAILTPGSE 277 + ++ LVD+IIA+R+ASG++ DDLLT +L KD + G+P+ ++ I Q++ L G E Sbjct: 232 DIKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHE 291 Query: 278 TIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPA 337 T + + + L L +P + +E V +++ V++L++ G V+ EA+RL P Sbjct: 292 TTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPT 351 Query: 338 VWVLTRRAVAESELGG-YRIPAGADIIYSPYAIQRDPKSY-DDNLEFDPDRWLPERAANV 395 + A ++ LGG Y + G +++ + RD + DD EF P+R+ E + + Sbjct: 352 APAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERF--ENPSAI 409 Query: 396 PKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRVGITLRPHDLL 455 P++A KPF G+R C F++ + TL+ + + FE ++ +TL+P + Sbjct: 410 PQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFV 469 Query: 456 VRPVAR 461 V+ ++ Sbjct: 470 VKAKSK 475 >3MDV-A nrPDB Length = 456 Score = 279 bits (713), Expect = 2e-75, Method: Composition-based stats. Identities = 102/422 (24%), Positives = 182/422 (43%), Gaps = 20/422 (4%) Query: 47 FMSQLRDHGDVVRIKLGPKTVYAVTNPELTGALALNPDYHIAGPLWESL-----EGLLGK 101 F+ + +G VVR+ + KT VT+PE ++ Y+ ++ +L E L G+ Sbjct: 16 FLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQ 75 Query: 102 EGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDATSESFRV 161 V+ N +QRR I AF ++ + E+A L E + + Sbjct: 76 GLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDM 135 Query: 162 AVRVAARCLLRGQYMDER-----AERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRF 216 A L + + E A++ + L R Sbjct: 136 LTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREV 195 Query: 217 NDALADLHLLVDEIIAERRAS----GQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAIL 272 +++ L + + + RR + + P D+LT +L+A++ D ++ + D V Sbjct: 196 RESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQD---DEGLLDNFVTFF 252 Query: 273 TPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGG-RPVAFEDVRKLRHTGNVIVEA 331 G ET A+ + + + L+ PE R++ EV+ V G R + FED+ +L++ V+ E+ Sbjct: 253 IAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKES 312 Query: 332 MRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPER 391 +RL P W R E+ + G R+P +++S Y + R ++D L F+PDR+ P Sbjct: 313 LRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGP-- 370 Query: 392 AANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRVGITLRP 451 A P++ PFS G R C F+ ++ ++ A L + F V G ++ TL+P Sbjct: 371 GAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKP 430 Query: 452 HD 453 D Sbjct: 431 LD 432 >6C94-A nrPDB Length = 497 Score = 277 bits (709), Expect = 6e-75, Method: Composition-based stats. Identities = 108/451 (23%), Positives = 190/451 (42%), Gaps = 37/451 (8%) Query: 26 VAGGGVPLLGHGWRLAR--DPLAFMSQLRDH---GDVVRIKLGPKTVYAVTNPELTGALA 80 L GH + + ++ + + + + P+ A+ Sbjct: 25 PGPPTHWLFGHALEIQKTGSLDKVVTWTQQFPYAHPLWVGQFIGF--LNIYEPDYAKAVY 82 Query: 81 LNPDYHIAGPLWESLEGLLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAH 140 D A +++ +GK G+ +GP + R+ + P F D + Y I + Sbjct: 83 SRGDP-KAPDVYDFFLQWIGK-GLLVLDGPKWFQHRKLLTPGFHYDVLKPYVAIFADSTR 140 Query: 141 ALTERWQP----GKTVDATSESFRVAVRVAARCLLRGQY--MDERAERLCVALATVFRGM 194 + E+W+ GK+ D S+ +A+ +C ++ R VA++ + M Sbjct: 141 IMLEKWEKKACEGKSFDIFSDVGHMALDTLMKCTFGKGDSGLNHRDSSYYVAVSELTLLM 200 Query: 195 YRRMVV---PLGPLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQKPD--------- 242 +R+ +Y L P RRF A H D +I +R+A+ Q Sbjct: 201 QQRIDSFQYHNDFIYWL-TPHGRRFLRACRAAHDHTDRVIRQRKAALQDEKEREKIQNRR 259 Query: 243 --DLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRI 300 D L LL+ + ++G + + ++ +V + G +T S I W L +A +PEH R Sbjct: 260 HLDFLDILLDVRGESGVQLSDTDLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQQRC 319 Query: 301 RDEVEAVTGGRPV-AFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESE-LGGYRIPA 358 R+EV + G + +ED+ K+ + + E RL P V + R+ + G +PA Sbjct: 320 REEVREILGDQDSFQWEDLAKMTYLTMCMKECFRLYPPVPQVYRQLSKPVSFVDGRSLPA 379 Query: 359 GADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMA 418 G+ I YA+ R+ + D FDP R+ PE ++ YA PFSAG R C F+M Sbjct: 380 GSLISLHIYALHRNSDVWPDPEVFDPLRFSPENSSGRHPYAFIPFSAGPRNCIGQQFAMN 439 Query: 419 QLTLITAALATKYRFEQVAGSNDAVRVGITL 449 ++ ++TA ++ F S D +R+ I L Sbjct: 440 EMKVVTALCLLRFEF-----SVDPLRLPIKL 465 >3DL9-A nrPDB Length = 479 Score = 277 bits (708), Expect = 8e-75, Method: Composition-based stats. Identities = 78/435 (17%), Positives = 165/435 (37%), Gaps = 22/435 (5%) Query: 44 PLAFMSQLRD-HGDVVRIKLGPKTVYAVTNPELTGA-LALNPDYHIAGPLWESLEGLLGK 101 P +M + +G++ + LG + + ++ L + P + Sbjct: 36 PHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKM 95 Query: 102 EGVATANGPL-HRRQRRTIQPAFRLDAI--PAYGPIMEEEAHALTERWQ--PGKTVDATS 156 G+ + RR +FR ++ + EE + + G+ D Sbjct: 96 GGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQ 155 Query: 157 ESFRVAVRVAARCLL--RGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYR---LPLP 211 + + R Y D + + + V LP Sbjct: 156 LITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFG 215 Query: 212 ANRRFNDALADLHLLVDEIIAERRASGQKP------DDLLTALLEAKDDNGDPIGEQEIH 265 +++ A ++ + +I + + + D L + + K+D ++ + Sbjct: 216 KHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLI 275 Query: 266 DQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTG-GRPVAFEDVRKLRHT 324 V ++ G+ET + + W + +A +P +++ E++ + G +++D K+ +T Sbjct: 276 FSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYT 335 Query: 325 GNVIVEAMRLRPAVWVLTRRAV-AESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFD 383 V+ E +R V + A ++ + GY IP G +I + Y++ D K + D F Sbjct: 336 EAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFH 395 Query: 384 PDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKY--RFEQVAGSND 441 P+R+L K A+ PFS G+R C +H + ++ L AL ++ F + Sbjct: 396 PERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDL 455 Query: 442 AVRVGITLRPHDLLV 456 R+G+TL+P L+ Sbjct: 456 KPRLGMTLQPQPYLI 470 >3TBG-A nrPDB Length = 479 Score = 272 bits (696), Expect = 2e-73, Method: Composition-based stats. Identities = 96/433 (22%), Positives = 159/433 (36%), Gaps = 24/433 (5%) Query: 38 WRLARDPLAFMSQLRDHGDVVRIKLGPKTVYAVTNPELTGALALNPDYHIAGPLWESLEG 97 P F R GDV ++L V + + A + Sbjct: 27 VDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQ 86 Query: 98 LLG-----KEGVATANGPLHRRQRRTIQPAFRLDAI--PAYGPIMEEEAHALTERWQ--P 148 +LG + GP R QRR R + + + EEA L + Sbjct: 87 ILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHS 146 Query: 149 GKTVDATSESFRVAVRVAAR--CLLRGQYMDERAERLCVALATVF---RGMYRRMVVPLG 203 G+ + V A C R +Y D R RL G R ++ + Sbjct: 147 GRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVP 206 Query: 204 PLYRLPLPANRRFNDALADLHLLVDEIIAERRAS---GQKPDDLLTALL----EAKDDNG 256 L +P A + +DE++ E R + Q P DL A L +AK + Sbjct: 207 VLLHIPALAG-KVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPE 265 Query: 257 DPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGG-RPVAF 315 ++ + V + + G T ++T+ W L + HP+ R++ E++ V G R Sbjct: 266 SSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEM 325 Query: 316 EDVRKLRHTGNVIVEAMRLRPAVWV-LTRRAVAESELGGYRIPAGADIIYSPYAIQRDPK 374 D + +T VI E R V + +T + E+ G+RIP G +I + ++ +D Sbjct: 326 GDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEA 385 Query: 375 SYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFE 434 ++ F P+ +L + V A PFSAG+R C + + +L L +L + F Sbjct: 386 VWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFS 445 Query: 435 QVAGSNDAVRVGI 447 G G+ Sbjct: 446 VPTGQPRPSHHGV 458 >2VZM-A nrPDB Length = 436 Score = 263 bits (672), Expect = 1e-70, Method: Composition-based stats. Identities = 83/440 (18%), Positives = 142/440 (32%), Gaps = 56/440 (12%) Query: 28 GGGVPLLGHGWRLARDPLAFMSQLRDHGDVVRIKLG-PKTVYAVTNPELTGALALNPDYH 86 + L G A DP ++LR G R++ V+ V + A+ +P + Sbjct: 32 PPVLDLGALGQDFAADPYPTYARLRAEGPAHRVRTPEGNEVWLVVGYDRARAVLADPRFS 91 Query: 87 IAGP----LWESLEGLLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHAL 142 E L + ++ P H R R+ + F + + P ++E L Sbjct: 92 KDWRNSTTPLTEAEAALNHN-MLESDPPRHTRLRKLVAREFTMRRVELLRPRVQEIVDGL 150 Query: 143 TERW--QPGKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVV 200 + P D + + L G +RA FR V Sbjct: 151 VDAMLAAPDGRADLMESL-AWPLPITVISELLGVPEPDRA---------AFRVWTDAFVF 200 Query: 201 PLGPLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIG 260 P P + A+A++ + +I +R GQ +DLL+AL+ D++G + Sbjct: 201 PDDP---------AQAQTAMAEMSGYLSRLIDSKR--GQDGEDLLSALVRTSDEDGSRLT 249 Query: 261 EQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRK 320 +E+ +L G ET + I + AL HP+ +R + Sbjct: 250 SEELLGMAHILLVAGHETTVNLIANGMYALLSHPDQLAALRAD----------------- 292 Query: 321 LRHTGNVIVEAMRLRPAVWV-LTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDN 379 + + E +R V R V +L G IPAG ++ R P+ + D Sbjct: 293 MTLLDGAVEEMLRYEGPVESATYRFPVEPVDLDGTVIPAGDTVLVVLADAHRTPERFPDP 352 Query: 380 LEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGS 439 FD R F G C + + + AL + + S Sbjct: 353 HRFDIRR---------DTAGHLAFGHGIHFCIGAPLARLEARIAVRALLERCPDLALDVS 403 Query: 440 NDAVRVGITLRPHDLLVRPV 459 + L P+ Sbjct: 404 PGELVWYPNPMIRGLKALPI 423 >5OFQ-A nrPDB Length = 409 Score = 262 bits (669), Expect = 3e-70, Method: Composition-based stats. Identities = 78/415 (18%), Positives = 146/415 (35%), Gaps = 48/415 (11%) Query: 44 PLAFMSQLRDHGDVVRIKLGPKTVYAVTNPELTGALALNPDYHIAGPLWESLEGLLGKEG 103 P + LR + R + + V + E + NP + E +E Sbjct: 30 PFDIYNSLRQEAPI-RYDE-SRNCWDVFDYETVKYILKNPSLFSSKRAMEE-----RQES 82 Query: 104 VATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDATSESFRVAV 163 + + P H + R + AF AI +EE A L + + D + F + Sbjct: 83 ILMMDPPKHTKLRNLVNKAFTPRAIQHLEGHIEEIADYLLDEVSSKEKFDIVED-FAGPL 141 Query: 164 RVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVP-LGPLYRLPLPANRRFNDALAD 222 + L G + +RA +F+ +V ++ N+ + Sbjct: 142 PIIVIAELLGVPIQDRA---------LFKKYSDDLVSGAENNSDEAFAKMMQKRNEGVIF 192 Query: 223 LHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIAST 282 L EIIAER+ + Q +DL++ LLEA+ D G+ + E+E+ + +L G+ET + Sbjct: 193 LQGYFKEIIAERQQNKQ--EDLISLLLEAEID-GEHLTEEEVLGFCILLLVAGNETTTNL 249 Query: 283 IMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLT 342 I ++ + + + + +R ++ V N++ E +R P + + Sbjct: 250 ITNGVRYMTEDVDVQNEVRRDISLVP-----------------NLVEETLRYYPPIQAIG 292 Query: 343 RRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKP 402 R A + ELG +I G +I + RD ++ F R Sbjct: 293 RIAAEDVELGECKIKRGQQVISWAASANRDSAKFEWPDTFVVHR---------KTNPHVS 343 Query: 403 FSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSND-AVRVGITLRPHDLLV 456 F G C + + + L K F +V + + + Sbjct: 344 FGFGIHFCLGAPLARMEGKIAFTKLLEKGGFSKVQNQSLKPIDSPFVFGVKKYEI 398 >5VBU-A nrPDB Length = 476 Score = 259 bits (662), Expect = 2e-69, Method: Composition-based stats. Identities = 97/470 (20%), Positives = 175/470 (37%), Gaps = 36/470 (7%) Query: 14 AAPGAPELREPPVAGGGVPLLGHGWRLARDPLAFMSQLRDHGDVVRIKLGPKTVYAVTNP 73 A + + + PP+A G + LL P+ + + G + R+ LG + V + + Sbjct: 2 AKKTSSKGKLPPLAPGFLHLLQPDL-----PIYLLGLTQKFGPIYRLHLGLQDVVVLNSK 56 Query: 74 ELTGALALNPDYHIAGPLWESLEGLLGKEG--VATANGPL-HRRQRRTIQPAFRLDAIPA 130 + AG L+ + ++ + L + ++ + A L + Sbjct: 57 RTIEEAMVKKWADFAGRPEPLTYKLVSRNYPDLSLGDYSLLWKAHKKLTRSALLLGIRDS 116 Query: 131 YGPIMEEEAHALTERW--QPGKTVDATSESFRVAVRVAARCLLRGQYMDER---AERLCV 185 P++E+ ER QPG V E + + + D+ A C+ Sbjct: 117 MEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKIKDDNLMPAYYKCI 176 Query: 186 ALATVFRGMYRRMVVPLGPLYRL-PLPANRRFNDALADLHLLVDEIIAERRASGQKP--D 242 + +V + P R P P RR A+ +V+ + + + S Sbjct: 177 QEVLKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWR 236 Query: 243 DLLTALLE-----AKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHA 297 D++ +L+ + ++ + E +H V +L G+ET A+T+ W + L HPE Sbjct: 237 DMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQ 296 Query: 298 DRIRDEVEAVTG----GRPVAFEDVRKLRHTGNVIVEAMRLRPAVW-VLTRRAVAESELG 352 R+++E++ G V ++D +L I E +RLRP V L R S + Sbjct: 297 QRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSIS 356 Query: 353 GYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPS 412 GY IP G II + D ++ EF PDR+L F G R C Sbjct: 357 GYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFL----EPGKNSRALAFGCGARVCLG 412 Query: 413 DHFSMAQLTLITAALATKYRFEQVAGSNDAVRVGI-----TLRPHDLLVR 457 + + +L ++ L + +G + L+ VR Sbjct: 413 EPLARLELFVVLTRLLQAFTL-LPSGDALPSLQPLPHCSVILKMQPFQVR 461 >5VWS-A nrPDB Length = 393 Score = 257 bits (656), Expect = 8e-69, Method: Composition-based stats. Identities = 84/403 (20%), Positives = 142/403 (35%), Gaps = 48/403 (11%) Query: 45 LAFMSQLRDHGDVVRIKLGPKTVYAVTNPELTGALALNPDYHIA--GPLWESLEGLLGKE 102 A++ +R+ V R + G +Y V + + + + L + +G GK Sbjct: 21 FAWLRTMRNEHPVWRDQFG---IYHVFRYDDVRQILGDYQTFSSDRTRLMPTAQG-FGKG 76 Query: 103 GVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDATSESFRVA 162 G+ + P HR QRR I AF +I A P + + A L + PG D E F Sbjct: 77 GITMIDPPEHRHQRRLITHAFTPQSISAMEPRIRQIADHLLDEL-PGPEFDLV-EHFAYP 134 Query: 163 VRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALAD 222 + V L G +R +FR R++ Y P A R A+ + Sbjct: 135 LPVIVIAELLGVPPGDRH---------LFRTWSDRLMSLQVENYADPELA-RTVAAAMTE 184 Query: 223 LHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIAST 282 ++ + E RR + DDLLT L++A+ + G + +E+ + +L G T Sbjct: 185 MNDYLREHCRSRRTHPR--DDLLTRLVQAEVE-GKRLDLEEVVNTASLLLLAGHLTTTVL 241 Query: 283 IMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLT 342 I + L DHPE +R + + + E++RLR Sbjct: 242 IGNTMLCLWDHPEAEKAVRADPSLIP-----------------AALEESLRLRSPFLQAG 284 Query: 343 RRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKP 402 R + + G IPA ++ + D + + D FD R Sbjct: 285 RVTTRDVTIAGETIPANRFVMAWILSANHDDRRFPDPERFDLHR---------QTTGHIA 335 Query: 403 FSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRV 445 F G C + + L ++ E + + Sbjct: 336 FGHGVHFCLGAQLGRLEGRIALERLLGRFT-EIHPWPREGISF 377 >3QZ1-A nrPDB Length = 496 Score = 254 bits (649), Expect = 5e-68, Method: Composition-based stats. Identities = 92/459 (20%), Positives = 169/459 (36%), Gaps = 35/459 (7%) Query: 24 PPVAGGGVPLLGHGWRLARDPLAFMSQLRDHGDVVRIKLGPKTVYAVTNPELTGALALNP 83 PP+ G + H + P+ +S + G V R++LG + V + + + Sbjct: 31 PPLVPGFL----HLLQPNL-PIHLLSLTQKLGPVYRLRLGLQEVVVLNSKRTIEEAMIRK 85 Query: 84 DYHIA-GPLWESLEGLLGK-EGVATANGPL-HRRQRRTIQPAFRLDAIPAYGPIMEEEAH 140 A P S + + + + ++ + L + ++ + A L + P +++ Sbjct: 86 WVDFAGRPQIPSYKLVSQRCQDISLGDYSLLWKAHKKLTRSALLLGTRSSMEPWVDQLTQ 145 Query: 141 ALTERW--QPGKTVDATSESFRVAVRVAARCLLRGQYMD--ERAERLCVALATVFRGMYR 196 ER Q G V E + + + L + Sbjct: 146 EFCERMRVQAGAPVTIQKEFSLLTCSIICYLTFGNKEDTLVHAFHDCVQDLMKTWDHWSI 205 Query: 197 RMVVPLGPLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQKP--DDLLTALLE---- 250 +++ + L P P R A+ + +V++ + + S D+ +L+ Sbjct: 206 QILDMVPFLRFFPNPGLWRLKQAIENRDHMVEKQLRRHKESMVAGQWRDMTDYMLQGVGR 265 Query: 251 -AKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTG 309 ++ + E +H VV + G+ET AST+ W + L HPE R+++E++ G Sbjct: 266 QRVEEGPGQLLEGHVHMSVVDLFIGGTETTASTLSWAVAFLLHHPEIQRRLQEELDRELG 325 Query: 310 ----GRPVAFEDVRKLRHTGNVIVEAMRLRPAVW-VLTRRAVAESELGGYRIPAGADIIY 364 V ++D +L I E +RLRP V L R S + GY IP G +I Sbjct: 326 PGASCSRVTYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSIFGYDIPEGMVVIP 385 Query: 365 SPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLIT 424 + D ++ EF PDR+L A + F G R C + + +L ++ Sbjct: 386 NLQGAHLDETVWEQPHEFRPDRFLEPGANP----SALAFGCGARVCLGESLARLELFVVL 441 Query: 425 AALATKYRFEQVAG------SNDAVRVGITLRPHDLLVR 457 A L + D G+ L+ VR Sbjct: 442 ARLLQAFTLLPPPVGALPSLQPDP-YCGVNLKVQPFQVR 479 >3MZS-A nrPDB Length = 486 Score = 253 bits (647), Expect = 1e-67, Method: Composition-based stats. Identities = 101/481 (20%), Positives = 177/481 (36%), Gaps = 50/481 (10%) Query: 19 PELREPPVAGGGVPLLGHGWR---LARDPLAFMSQLRDHGDVVRIKLGP-KTVYAVTNPE 74 P P G L H WR R + + +G + R KLG ++VY + + Sbjct: 9 PYSEIPSPGDNGWLNLYHFWREKGSQRIHFRHIENFQKYGPIYREKLGNLESVYIIHPED 68 Query: 75 LTGALALNPDY--HIAGPLWESLEGLLGKE-GVATANGPLHRRQR-----RTIQPAFRLD 126 + Y P W + K GV ++ R + P + Sbjct: 69 VAHLFKFEGSYPERYDIPPWLAYHRYYQKPIGVLFKKSGTWKKDRVVLNTEVMAPEAIKN 128 Query: 127 AIPAYGPIMEEEAHALTERWQP---GKTV-DATSESFRVAVRVAA------RCLLRGQYM 176 IP P+ ++ L +R + GK V D + F A R + + + Sbjct: 129 FIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETV 188 Query: 177 DERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRR---------FNDALADLHLLV 227 + A++ A+ +F + VP LYRL R FN A + Sbjct: 189 NPEAQKFIDAVYKMFHTSVPLLNVP-PELYRLFRTKTWRDHVAAWDTIFNKAEKYTEIFY 247 Query: 228 DEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLL 287 ++ R+ + +L LL+++ + +++ + +L G T + T+ W L Sbjct: 248 QDL--RRKTEFRNYPGILYCLLKSE-----KMLLEDVKANITEMLAGGVNTTSMTLQWHL 300 Query: 288 QALADHPEHADRIRDEVEAVTGGRPVAFEDVRKL----RHTGNVIVEAMRLRPAVWVLTR 343 +A + +R+E V R A D+ K+ I E +RL P L R Sbjct: 301 YEMARSLNVQEMLREE---VLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQR 357 Query: 344 RAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPF 403 ++ L Y IPA + + YA+ RDP + +FDP RWL + ++ + F Sbjct: 358 YPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWL-SKDKDLIHFRNLGF 416 Query: 404 SAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRVGITL---RPHDLLVRPVA 460 G R+C + ++TL + ++ E + + L +P L+ RP Sbjct: 417 GWGVRQCVGRRIAELEMTLFLIHILENFKVEMQHIGDVDTIFNLILTPDKPIFLVFRPFN 476 Query: 461 R 461 + Sbjct: 477 Q 477 >5L94-A nrPDB Length = 410 Score = 251 bits (642), Expect = 4e-67, Method: Composition-based stats. Identities = 76/420 (18%), Positives = 153/420 (36%), Gaps = 47/420 (11%) Query: 43 DPLAFMSQLRDHGDVVRIKLGPKTVYAVTNPELTGALALNPDYHIA--GPLWESLEGLLG 100 +P ++ ++R+ V + + V+ V + + + + + P + LG Sbjct: 24 NPFSWYEEMRNTAPVQWDEE--RQVWDVFHYDGVKEVLEQKNIFSSDRRPPQNQRQTALG 81 Query: 101 KEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDATSESFR 160 + + P H R + AF A+ A+ P + + L + + + +D E Sbjct: 82 T-SLINIDPPKHAEMRALVNKAFTPKAMKAWEPKIARITNELLQEVEHLEDIDIV-EHLS 139 Query: 161 VAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPA-NRRFNDA 219 + V + G ++++ + F+ +V R L + A Sbjct: 140 YPLPVMVIADILGVPIEDQRQ---------FKDWSDIIVAGPSNNERETLEKLQQEKMKA 190 Query: 220 LADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETI 279 +L II E+R + DD+++ LL+AK++ G + ++EI + +L G+ET Sbjct: 191 NDELETYFYRIIEEKRT--RPGDDIISVLLQAKEE-GKQLTDEEIVGFSILLLIAGNETT 247 Query: 280 ASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVW 339 + I + L + +R++ E E + G I E +R R V Sbjct: 248 TNLISNTIYCLMEDKASFERLKREKELLPSG-----------------IEEVLRYRSPVQ 290 Query: 340 VLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYA 399 L R + L G ++ AG ++ + RD + ++D F DR Sbjct: 291 ALHRIVKEDVTLAGKKLKAGEHVVPWMGSAHRDAEYFEDPEVFKIDR---------KPNV 341 Query: 400 MKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQ--VAGSNDAVRVGITLRPHDLLVR 457 F G C + + ++ A L +Y + + +LL+R Sbjct: 342 HMAFGRGIHFCLGAPLARIEAKIMLAELIDRYPQMDWSPSFELKPIESTFVYGLKELLIR 401 >4UBS-A nrPDB Length = 393 Score = 249 bits (636), Expect = 2e-66, Method: Composition-based stats. Identities = 82/426 (19%), Positives = 140/426 (32%), Gaps = 55/426 (12%) Query: 43 DPLAFMSQLRDHGDVVRIKLG-PKTVYAVTNPELTGALALNPDYHIAG--PLWESLEGLL 99 DP LR+ + R+ L ++V+ VT AL + P + + Sbjct: 14 DPPTAYDPLREGRPLSRVSLYDGRSVWVVTGHAAARALLSDQRLSSDRTLPRFPATTERF 73 Query: 100 -----GKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDA 154 + + + P HR QRR + P+F L A P ++E L + + Sbjct: 74 EAVRTRRVALLGVDDPEHRTQRRMLVPSFTLKRAAALRPRIQETVDGLLDAMEAQGPPAE 133 Query: 155 TSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANR 214 +F + + C L G + F RR+ L P Sbjct: 134 LVSAFALPLPSMVICALLGVPYADHD---------FFESQSRRL---------LRGPGIA 175 Query: 215 RFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTP 274 DA A L + +I +R + D LL L++ + + G + E+ +L Sbjct: 176 EVQDARAQLDDYLYALIDRKRK--EPGDGLLDDLIQEQLNRGT-VDRAELVSLATLLLIA 232 Query: 275 GSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRL 334 G ET A+ I L HPE +R E + + E +R Sbjct: 233 GHETTANMISLGTFTLLRHPEQLAELRAEPGLMP-----------------AAVEELLRF 275 Query: 335 RPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAAN 394 L R A + E+ G I A ++++ I RD + + D R Sbjct: 276 LSIADGLLRVATEDIEVAGTTIRADEGVVFATSVINRDAAGFAEPDALDWHR-------- 327 Query: 395 VPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRVGITLRPHDL 454 F G +C + + A++ + L + ++A D + + Sbjct: 328 -SARHHVAFGFGIHQCLGQNLARAEMEIALGTLFERLPGLRLAAPADEIPFKPGDTIQGM 386 Query: 455 LVRPVA 460 L PV Sbjct: 387 LELPVT 392 >3WVS-A nrPDB Length = 401 Score = 248 bits (634), Expect = 3e-66, Method: Composition-based stats. Identities = 93/417 (22%), Positives = 158/417 (37%), Gaps = 54/417 (12%) Query: 48 MSQLRDHGDVVRIKLG-PKTVYAVTNPELTGALALNPDYHIA----GPLWESLEGLLGKE 102 ++ RD ++R+KL + + T E + + + A + + + Sbjct: 29 YTRARDTDGLIRVKLPYGEPAWLATRYEDARLVLGDARFSRALSEEHDPPRARKFNAQAK 88 Query: 103 GVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALT-ERWQPGKTVDATSESFRV 161 + + P H R RR I AF + + P + + AH L + G+ D ++ + + Sbjct: 89 SMFNMDAPDHTRLRRLISKAFTIRRVEELRPKVHDLAHRLIDDMLAKGEPADLVAD-YAL 147 Query: 162 AVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALA 221 + C L G ++R + G + ++ L P R Sbjct: 148 PIPTTVICELLGVPFEDREKF----------GRWTDAILSTSTL----NPEEGRVKRM-- 191 Query: 222 DLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIAS 281 +L + IIA RRA Q DDL++ ++EA+D D + EQE+ D + +L G ET AS Sbjct: 192 ELVGYIGGIIAARRA--QPADDLISGMIEARDVQ-DKLTEQELLDHCIGLLIAGHETTAS 248 Query: 282 TIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRP--AVW 339 I + AL D P+H R+ D+ E + + + E R P + Sbjct: 249 QIPSFVYALLDQPQHWKRLLDDPELIP-----------------SAVEELFRFVPLGSGS 291 Query: 340 VLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYA 399 R A + E+GG + AG ++ + A RD ++D E DR P Sbjct: 292 AAPRYAREDIEVGGTLVRAGEPVLVALGAANRDGLRFEDPEEIKLDR---------PSNH 342 Query: 400 MKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRVGITLRPHDLLV 456 F G C + +L AL + +VAG + P + V Sbjct: 343 HIGFGHGIHHCLGAPLARLELQEALRALLERLPTLKVAGDIAWKSEMMVRGPRSMPV 399 >3NC3-A nrPDB Length = 441 Score = 247 bits (631), Expect = 7e-66, Method: Composition-based stats. Identities = 79/422 (18%), Positives = 161/422 (38%), Gaps = 39/422 (9%) Query: 39 RLARDPLAFMSQLRDHGDVVRIKLGPKTVYAVTNPELTGALALNPDYHIAGPLWESLEGL 98 + +P A+ SQLR+ V Y ++ + +PD L E E + Sbjct: 50 QFQNNPYAYFSQLREEDPVH--YEESIDSYFISRYHDVRYILQHPDIFTTKSLVERAEPV 107 Query: 99 LGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDATSES 158 + +A +G H +RR + +F DA+ P++++ A L + D ++ Sbjct: 108 MRGPVLAQMHGKEHSAKRRIVVRSFIGDALDHLSPLIKQNAENLLAPYLERGKSDLVNDF 167 Query: 159 FRV-AVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFN 217 + AV V L + E+ +A + + P R + Sbjct: 168 GKTFAVCVTMDMLGLDKRDHEKISEWHSGVADFITSISQS-------------PEARAHS 214 Query: 218 DALAD-LHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGS 276 ++ L + +I ERR + DL++ L ++ + G + +++I ++ +L + Sbjct: 215 LWCSEQLSQYLMPVIKERRVN--PGSDLISILCTSEYE-GMALSDKDILALILNVLLAAT 271 Query: 277 ETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRP 336 E T+ ++ L ++PE + + + V I E +R +P Sbjct: 272 EPADKTLALMIYHLLNNPEQMNDVLADRSLVP-----------------RAIAETLRYKP 314 Query: 337 AVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRW-LPERAANV 395 V ++ R+ ++ +GG I + A RDP++++ F+ R L ++A Sbjct: 315 PVQLIPRQLSQDTVVGGMEIKKDTIVFCMIGAANRDPEAFEQPDVFNIHREDLGIKSAFS 374 Query: 396 PKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRVGI-TLRPHDL 454 F +G C F+ ++ ++ + K R ++ G+ T P L Sbjct: 375 GAARHLAFGSGIHNCVGTAFAKNEIEIVANIVLDKMRNIRLEEDFCYAESGLYTRGPVSL 434 Query: 455 LV 456 LV Sbjct: 435 LV 436 >4YZR-A nrPDB Length = 405 Score = 247 bits (631), Expect = 7e-66, Method: Composition-based stats. Identities = 70/429 (16%), Positives = 150/429 (34%), Gaps = 65/429 (15%) Query: 33 LLGHGWRLARDPLAFMSQLRDHGDVVRIKL----GPKTVYAVTNPELTGALALNPDYHIA 88 HG +P + + + R+ + R +L + +T + A D I Sbjct: 6 FHPHGKEFHHNPFSVLGRFREEEPIHRFELKRFGATYPAWLITRYDDCMAFL--KDNRIT 63 Query: 89 GPLWESL------------EGLLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIME 136 + + + + + + P H R R + AF I +E Sbjct: 64 RDVKNVMNQEQIKMLNVSEDIDFVSDHMLAKDTPDHTRLRSLVHQAFTPRTIENLRGSIE 123 Query: 137 EEAHALTERWQPGKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYR 196 + A L + + D +SF + L G ++R++ ++ Sbjct: 124 QIAEQLLDEMEKENKADIM-KSFASPLPFIVISELMGIPKEDRSQF----------QIWT 172 Query: 197 RMVVPLGPLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNG 256 +V R N AL + + ++I +RR + DDL++ L+ A+ +NG Sbjct: 173 NAMVDTSEGNR------ELTNQALREFKDYIAKLIHDRR--IKPKDDLISKLVHAE-ENG 223 Query: 257 DPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFE 316 + E+E++ + ++ G ET + + AL H + ++++ + E + Sbjct: 224 SKLSEKELYSMLFLLVVAGLETTVNLLGSGTLALLQHKKECEKLKQQPEMI--------- 274 Query: 317 DVRKLRHTGNVIVEAMRLRPAVWVLT-RRAVAESELGGYRIPAGADIIYSPYAIQRDPKS 375 + E +R V ++ R A+ + G+ I G I + RDP Sbjct: 275 --------ATAVEELLRYTSPVVMMANRWAIEDFTYKGHSIKRGDMIFIGIGSANRDPNF 326 Query: 376 YDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQ 435 +++ + +R F G C + + + AL ++ + Sbjct: 327 FENPEILNINR---------SPNRHISFGFGIHFCLGAPLARLEGHIAFKALLKRFPDIE 377 Query: 436 VAGSNDAVR 444 +A + D ++ Sbjct: 378 LAVAPDDIQ 386 >3A50-A nrPDB Length = 411 Score = 247 bits (630), Expect = 8e-66, Method: Composition-based stats. Identities = 68/396 (17%), Positives = 127/396 (32%), Gaps = 53/396 (13%) Query: 39 RLARDPLAFMSQLRDHGDVVRIKLGPKTVYAVTNPELTGALALNPDYHIAGPLWESLE-- 96 ++P + LR V ++ L V+ +T ++P + Sbjct: 17 TFWQNPHPAYAALRAEDPVRKLALPDGPVWLLTRYADVREAFVDPRLSKDWRHRLPEDQR 76 Query: 97 ---GLLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVD 153 + + P H R R+ + +F + + P + E A L VD Sbjct: 77 ADMPATPTPMMILMDPPDHTRLRKLVGRSFTVRRMNELEPRITEIADGLLAGLPTDGPVD 136 Query: 154 ATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPAN 213 E + + V C L G ++R + + PA+ Sbjct: 137 LMRE-YAFQIPVQVICELLGLPAEDRDD-----------------FSAWSSVLVDDSPAD 178 Query: 214 RRFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILT 273 + N A+ LH + +++ +R + D LL++LL D +GD + ++E+ + +L Sbjct: 179 DK-NAAMGKLHGYLSDLLERKRT--EPDDALLSSLLAVSDMDGDRLSQEELVAMAMLLLI 235 Query: 274 PGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMR 333 G ET + I + AL HP+ + ++ + + + E +R Sbjct: 236 AGHETTVNLIGNGVLALLTHPDQRKLLAEDPSLI-----------------SSAVEEFLR 278 Query: 334 LRPAVWVLT-RRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERA 392 V R + G IPAG ++ A RD + D R Sbjct: 279 FDSPVSQAPIRFTAEDVTYSGVTIPAGEMVMLGLAAANRDADWMPEPDRLDITR------ 332 Query: 393 ANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALA 428 F G C + + + L Sbjct: 333 ---DASGGVFFGHGIHFCLGAQLARLEGRVAIGRLF 365 >1UED-A nrPDB Length = 406 Score = 247 bits (630), Expect = 9e-66, Method: Composition-based stats. Identities = 90/442 (20%), Positives = 153/442 (34%), Gaps = 73/442 (16%) Query: 18 APELREPPVAGGGVPLLGHGWRLARDPLAFMSQLRDHGDVVRI------KLGPKTVYAVT 71 AP LREP R DP LR HG +VRI +LG V+ Sbjct: 9 APLLREPA---------NFQLRTNCDPHEDNFGLRAHGPLVRIVGESSTQLGRDFVWQAH 59 Query: 72 NPELTGALALNPDYHIAGPLWESLE-----GLLGKEGVATANGPLHRRQRRTIQPAFRLD 126 E+ + + ++ P + + ++T + P H R R+ + P F + Sbjct: 60 GYEVVRRILGDHEHFTTRPQFTQSKSGAHVEAQFVGQISTYDPPEHTRLRKMLTPEFTVR 119 Query: 127 AIPAYGPIMEEEAHALTERWQPGKTVDATSESFRVAVRVAARCLLRGQYMDERAE--RLC 184 I P ++ + + F V A C L G D++ E R Sbjct: 120 RIRRMEPAIQSLIDDRLDLLEAEGPSADLQGLFADPVGAHALCELLGIPRDDQREFVRRI 179 Query: 185 VALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQKPDDL 244 A + RG+ R A + +D ++A +RA PDD Sbjct: 180 RRNADLSRGLKARAADS-------------------AAFNRYLDNLLARQRAD---PDDG 217 Query: 245 LTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEV 304 L ++ D+GD + ++E+ A++ G ET+A I + + AL D+P + + + Sbjct: 218 LLGMIVR--DHGDNVTDEELKGLCTALILGGVETVAGMIGFGVLALLDNPGQIELLFESP 275 Query: 305 EAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWV-LTRRAVAESELGGYRIPAGADII 363 E V+ E +R V R A+ + + G I AG ++ Sbjct: 276 EK-----------------AERVVNELVRYLSPVQAPNPRLAIKDVVIDGQLIKAGDYVL 318 Query: 364 YSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLI 423 S RD D D +R + F G C + + L + Sbjct: 319 CSILMANRDEALTPDPDVLDANR---------AAVSDVGFGHGIHYCVGAALARSMLRMA 369 Query: 424 TAALATKYRFEQVAGSNDAVRV 445 L ++ ++A + V+ Sbjct: 370 YQTLWRRFPGLRLAVPIEEVKY 391 >6IQ5-A nrPDB Length = 463 Score = 247 bits (630), Expect = 9e-66, Method: Composition-based stats. Identities = 88/456 (19%), Positives = 157/456 (34%), Gaps = 35/456 (7%) Query: 41 ARDPLAFMSQLRDHGDVVRIKLGPKTVYAVTNP-ELTGALALNPDYHIAGPLWESLEGLL 99 L+F R +GDV +I+LG + + + AL P + S + Sbjct: 1 QAAHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPSFASFRVVS 60 Query: 100 GKEGVATANGPL-HRRQRRTIQPAFR------LDAIPAYGPIMEEEAHALTERW----QP 148 G +A + + QRR R + + EA L Sbjct: 61 GGRSMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALLVRGSAD 120 Query: 149 GKTVDATSESFRVAVRVAARCLLRGQY--MDERAERLCVALATVFRGMYRRMVVPLGPLY 206 G +D + V + +Y D L R + +V + P Sbjct: 121 GAFLDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSLVDVMPWL 180 Query: 207 R-LPLPAN---RRFNDALADLHLLVDEIIAERRASGQK---PDDLLTALLEAKDDN---- 255 + P P R F + + + S + P D++ A + + + Sbjct: 181 QYFPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAAGD 240 Query: 256 ----GDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTG-G 310 G + + + + I +T+++ + WLL +P+ R++ E++ V G Sbjct: 241 SHGGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRD 300 Query: 311 RPVAFEDVRKLRHTGNVIVEAMRLRPAVW-VLTRRAVAESELGGYRIPAGADIIYSPYAI 369 R D L + + EAMR V + A + + GY IP + + +++ Sbjct: 301 RLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSV 360 Query: 370 QRDPKSYDDNLEFDPDRWLPERAANVPKY--AMKPFSAGKRKCPSDHFSMAQLTLITAAL 427 DP + + FDP R+L + + FS GKR+C + S QL L + L Sbjct: 361 NHDPVKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISIL 420 Query: 428 ATKYRFEQVAGSNDAVRV--GITLRPHDLLVRPVAR 461 A + F + G+T++P V R Sbjct: 421 AHQCDFRANPNEPAKMNFSYGLTIKPKSFKVNVTLR 456 >4RM4-A nrPDB Length = 396 Score = 246 bits (628), Expect = 2e-65, Method: Composition-based stats. Identities = 65/415 (15%), Positives = 137/415 (33%), Gaps = 46/415 (11%) Query: 44 PLAFMSQLRDHGDVVRIKLGPKTVYAVTNPELTGALALNPDYHIAGPLWESLEGLLGKEG 103 P + +R V + V++V + + + + + ++ Sbjct: 26 PFPWYESMRKDAPVSFDEE--NQVWSVFLYDDVKKVVGDKELFSSCMPQQTSSI---GNS 80 Query: 104 VATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDATSESFRVAV 163 + + P H + R + AF + + P ++E L +++Q D + F + Sbjct: 81 IINMDPPKHTKIRSVVNKAFTPRVMKQWEPRIQEITDELIQKFQGRSEFDLVHD-FSYPL 139 Query: 164 RVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPA-NRRFNDALAD 222 V L G F+ +V A + + Sbjct: 140 PVIVISELLGVPSAH---------MEQFKAWSDLLVSTPKDKSEEAEKAFLEERDKCEEE 190 Query: 223 LHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIAST 282 L II E+R ++ D+++ L+EA+ + G+ + +E+ +L G+ET + Sbjct: 191 LAAFFAGIIEEKRNKPEQ--DIISILVEAE-ETGEKLSGEELIPFCTLLLVAGNETTTNL 247 Query: 283 IMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLT 342 I + ++ + P + +R E + + EA+R R VL Sbjct: 248 ISNAMYSILETPGVYEELRSHPELMP-----------------QAVEEALRFRAPAPVLR 290 Query: 343 RRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKP 402 R A ++E+GG+ I G ++ + RD +D FD R Sbjct: 291 RIAKRDTEIGGHLIKEGDMVLAFVASANRDEAKFDRPHMFDIRR---------HPNPHIA 341 Query: 403 FSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRVGITLRPHDLLVR 457 F G C + + + +L + + + + + V+ Sbjct: 342 FGHGIHFCLGAPLARLEANIALTSLISAFPHMECVSIT-PIENSVIYGLKSFRVK 395 >1Z8P-A nrPDB Length = 404 Score = 246 bits (627), Expect = 2e-65, Method: Composition-based stats. Identities = 84/436 (19%), Positives = 146/436 (33%), Gaps = 62/436 (14%) Query: 39 RLARDPLAFMSQLRDHGDVVRIKLGPKTVYAVTNPELTGALA----LNPDYHIAGPLWES 94 D ++LR+ V ++ + + VT + A L+ D P E Sbjct: 11 SFHVDWYRTYAELRETAPVTPVRFLGQDAWLVTGYDEAKAALSDLRLSSDPKKKYPGVEV 70 Query: 95 LEGLLGK----------EGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTE 144 + T++ P H R R+ + F + + A P +E+ L + Sbjct: 71 EFPAYLGFPEDVRNYFATNMGTSDPPTHTRLRKLVSQEFTVRRVEAMRPRVEQITAELLD 130 Query: 145 RWQPGKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGP 204 VD + F + + C L G +RG + R Sbjct: 131 EVGDSGVVDIV-DRFAHPLPIKVICELLGVD-------------EKYRGEFGRWSS---E 173 Query: 205 LYRLPLPANRRFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEI 264 + + + A ++ + +++ RR + DDLL+AL+ +DD+ + E+ Sbjct: 174 ILVMDPERAEQRGQAAREVVNFILDLVERRRT--EPGDDLLSALIRVQDDDDGRLSADEL 231 Query: 265 HDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHT 324 + +L G E+ S I L HP+ +R + A+ Sbjct: 232 TSIALVLLLAGFESSVSLIGIGTYLLLTHPDQLALVRRDPSALP---------------- 275 Query: 325 GNVIVEAMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDP 384 N + E +R TR A E E+GG IP + ++ + A RDPK + D FD Sbjct: 276 -NAVEEILRYIAPPETTTRFAAEEVEIGGVAIPQYSTVLVANGAANRDPKQFPDPHRFDV 334 Query: 385 DRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAV- 443 R F G C + + + AL ++ + D V Sbjct: 335 TR---------DTRGHLSFGQGIHFCMGRPLAKLEGEVALRALFGRFPALSLGIDADDVV 385 Query: 444 --RVGITLRPHDLLVR 457 R + L VR Sbjct: 386 WRRSLLLRGIDHLPVR 401 >4Z5Q-A nrPDB Length = 423 Score = 243 bits (620), Expect = 1e-64, Method: Composition-based stats. Identities = 93/444 (20%), Positives = 152/444 (34%), Gaps = 56/444 (12%) Query: 20 ELREPPVAGGGVPLLGH-GWRLARDPLAFMSQLRDHGDVVRIKLG-PKTVYAVTNPELTG 77 E+ A P G G L++ GD +R++L + + VT + Sbjct: 27 EVETEKPAPVAYPFTGSEGLELSQSYAKLFED----GDPIRVQLPFGEPAWLVTRYDDAR 82 Query: 78 ALALNPDYHI---AGPLWESLEGLLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPI 134 + + + + E + T + P H R R + AF I + Sbjct: 83 FVLTDRRFSRHLATQRDEPRMTPRAVPESILTMDPPDHTRLRTLVSKAFTPRRIESKRAW 142 Query: 135 MEEEAHALTERWQPGKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGM 194 + E A L + G S+ +A+ V C L G D+R T RG Sbjct: 143 IGELAAGLVADMKAGGAPAELVGSYALAIPVTVICELLGVPEDDR---------TRLRGW 193 Query: 195 YRRMVVPLGPLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDD 254 + + + DL ++++ ERRA + DDL +AL+EA+D Sbjct: 194 CDAALST-------GELTDEECVQSFMDLQKYFEDLVKERRA--EPRDDLTSALIEARDA 244 Query: 255 NGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVA 314 D + E E+ ++IL G ET AS I + L E R+ + EA+ Sbjct: 245 -HDRLAEPELIGLCISILIGGFETTASEISSFVHVLQQRRELWTRLCADPEAIP------ 297 Query: 315 FEDVRKLRHTGNVIVEAMRLRPAVWVL--TRRAVAESELGGYRIPAGADIIYSPYAIQRD 372 + E +R P R A+ + +GG + G +I A+ RD Sbjct: 298 -----------AAVEELLRFVPFAANGISPRYALEDMTVGGVLVREGEPVIVDTSAVNRD 346 Query: 373 PKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYR 432 +D+ E DR F G C H + +L AL Sbjct: 347 GLVFDNADEVVIDRADN---------RHMVFGHGAHHCLGAHLARVELQEALKALVEGMP 397 Query: 433 FEQVAGSNDAVRVGITLRPHDLLV 456 +++G + I P + V Sbjct: 398 GLRLSGDVEWKADMIIRAPRVMHV 421 >3N9Z-A nrPDB Length = 487 Score = 242 bits (617), Expect = 3e-64, Method: Composition-based stats. Identities = 100/486 (20%), Positives = 168/486 (34%), Gaps = 45/486 (9%) Query: 10 TRAPAAPGAPELREPPVAGGGVPLLGHGWR---LARDPLAFMSQLRDHGDVVRIKLGPKT 66 TR+P P P G L H WR + L + + +G + R KLG Sbjct: 2 TRSPR----PFNEIPSPGDNGWLNLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVE 57 Query: 67 VYAVTNPELTGALALNPD---YHIAGPLWESLEGLLGKE-GVATANGPLHRRQR-----R 117 V +PE L + P W + + GV ++ R Sbjct: 58 SVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQE 117 Query: 118 TIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTV----DATSESFRVAVRVAARCLL-- 171 + P + +P + + L R + + D + + FR A + Sbjct: 118 VMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGE 177 Query: 172 ----RGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDA-----LAD 222 + ++ A+R A+ +F + +P L+RL + + A + Sbjct: 178 RQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPD-LFRLFRTKTWKDHVAAWDVIFSK 236 Query: 223 LHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIAST 282 + E R G D L D + ++I V +L G +T + T Sbjct: 237 ADIYTQNFYWELRQKGSVHHDYRGILYRLLGD--SKMSFEDIKANVTEMLAGGVDTTSMT 294 Query: 283 IMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKL----RHTGNVIVEAMRLRPAV 338 + W L +A + + D +R E V R A D+ + I E +RL P Sbjct: 295 LQWHLYEMARNLKVQDMLRAE---VLAARHQAQGDMATMLQLVPLLKASIKETLRLHPIS 351 Query: 339 WVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKY 398 L R V + L Y IPA + + YA+ R+P + D FDP RWL + N+ + Sbjct: 352 VTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWL-SKDKNITYF 410 Query: 399 AMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRVGITLRPHD---LL 455 F G R+C + ++T+ + +R E S+ + L P Sbjct: 411 RNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKPISFT 470 Query: 456 VRPVAR 461 P + Sbjct: 471 FWPFNQ 476 >1ODO-A nrPDB Length = 408 Score = 241 bits (616), Expect = 4e-64, Method: Composition-based stats. Identities = 96/420 (22%), Positives = 162/420 (38%), Gaps = 63/420 (15%) Query: 41 ARDPLAFMSQLRDHGDVVRIKLGPKTVYAVTNPELTGALALNPDYHI-AGPLWESLEGLL 99 D LR+ G + + ++V++P L L + D A W + ++ Sbjct: 14 GADHHTEHRTLREGGPATWVDVLGVQAWSVSDPVLLKQLLTSSDVSKDARAHWPAFGEVV 73 Query: 100 GK---------EGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQP-- 148 G E + TA GP HR+ RR + PAF + A P +E L +R Sbjct: 74 GTWPLALWVAVENMFTAYGPNHRKLRRLVAPAFSARRVDAMRPAVEAMVTGLVDRLAELP 133 Query: 149 -GKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYR 207 G+ VD E + +A L G D R + G++ + Sbjct: 134 AGEPVDLRQEL-AYPLPIAVIGHLMGVPQDRRD-----GFRALVDGVFDTTL-------- 179 Query: 208 LPLPANRRFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDD--NGDPIGEQEIH 265 A L+ ++D++IA +RA+ DD+ + L+ A+DD +GD + +E+ Sbjct: 180 ----DQAEAQANTARLYEVLDQLIAAKRAT--PGDDMTSLLIAARDDEGDGDRLSPEELR 233 Query: 266 DQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTG 325 D ++ +++ G ET + I + L P+ +R V + D Sbjct: 234 DTLLLMISAGYETTVNVIDQAVHTLLTRPDQLALVRK--------GEVTWAD-------- 277 Query: 326 NVIVEAMRLRPAVWVLT-RRAVAESEL-GGYRIPAGADIIYSPYAIQRDPKSYDDNLEFD 383 V+ E +R PAV L R AV + L G I G I+ S A R P ++D FD Sbjct: 278 -VVEETLRHEPAVKHLPLRYAVTDIALPDGRTIARGEPILASYAAANRHPDWHEDADTFD 336 Query: 384 PDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAV 443 R + E F G C + ++TL +L ++ ++A + + Sbjct: 337 ATRTVKE---------HLAFGHGVHFCLGAPLARMEVTLALESLFGRFPDLRLADPAEEL 387 >2Y5N-A nrPDB Length = 417 Score = 241 bits (616), Expect = 4e-64, Method: Composition-based stats. Identities = 83/418 (19%), Positives = 140/418 (33%), Gaps = 58/418 (13%) Query: 50 QLRDHGDVVRIKLG-PKTVYAVTNPELTGALALNPDYHIA---GPLWESLEGLLGKEGVA 105 +L++ V R++ + + VT E A+ + + + K G+ Sbjct: 45 ELQETEPVSRVRPPYGEEAWLVTRYEDVRAVLGDGRFVRGPSMTRDEPRTRPEMVKGGLL 104 Query: 106 TANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDATSESFRVAVRV 165 + + P H R RR + AF + P E AH L ++ F + V Sbjct: 105 SMDPPEHSRLRRLVVKAFTARRAESLRPRAREIAHELVDQMAATGQPADLVAMFARQLPV 164 Query: 166 AARCLLRGQY--MDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALADL 223 C L G +R R A + M +A Sbjct: 165 RVICELLGVPSADHDRFTRWSGAFLSTAEVTAEEM------------------QEAAEQA 206 Query: 224 HLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTI 283 + + ++I RR + DDL++AL++A+D D + EQE+ D + +L G E+ + I Sbjct: 207 YAYMGDLIDRRRK--EPTDDLVSALVQARDQQ-DSLSEQELLDLAIGLLVAGYESTTTQI 263 Query: 284 MWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRP--AVWVL 341 + L PE ++ D E + + + E R P Sbjct: 264 ADFVYLLMTRPELRRQLLDRPELIP-----------------SAVEELTRWVPLGVGTAF 306 Query: 342 TRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMK 401 R AV + L G I AG ++ S A RD + D D DR Sbjct: 307 PRYAVEDVTLRGVTIRAGEPVLASTGAANRDQAQFPDADRIDVDR---------TPNQHL 357 Query: 402 PFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRVG---ITLRPHDLLV 456 F G C + +L + L + ++ +R + P +L V Sbjct: 358 GFGHGVHHCLGAPLARVELQVALEVLLQRLPGIRLGIPETQLRWSEGMLLRGPLELPV 415 >5LIE-A nrPDB Length = 414 Score = 241 bits (615), Expect = 4e-64, Method: Composition-based stats. Identities = 85/428 (19%), Positives = 145/428 (33%), Gaps = 56/428 (13%) Query: 44 PLAFMSQLRDHGDVVRIKLGPKT-----VYAVTNPELTGALALNP--DYHIAGPLWESLE 96 P + R V + T ++V T + +P + G Sbjct: 23 PHHLFAIHRREAPVYWHRPTEHTPDGEGFWSVATYAETLEVLRDPVTYSSVTGGQRRFGG 82 Query: 97 GLLG-----KEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKT 151 +L + + + P H R RR + I + A L + +PG Sbjct: 83 TVLQDLPVAGQVLNMMDDPRHTRIRRLVSSGLTPRMIRRVEDDLRRRARGLLDGVEPGAP 142 Query: 152 VDATSESFRVAVRVAARCLLRGQYMDERAERL-CVALATVFRGMYRRMVVPLGPLYRLPL 210 D E + + C+L G +R V FRG R + L Sbjct: 143 FDFVVEI-AAELPMQMICILLGVPETDRHWLFEAVEPGFDFRGSRRATMPRL-------- 193 Query: 211 PANRRFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDP--IGEQEIHDQV 268 DA + L+ E+IA +RA + DD+L+ + A D+ D + + E++ Sbjct: 194 ----NVEDAGSRLYTYALELIAGKRA--EPADDMLSVVANATIDDPDAPALSDAELYLFF 247 Query: 269 VAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVI 328 + + G+ET ++I L ALA++P+ +R + E + I Sbjct: 248 HLLFSAGAETTRNSIAGGLLALAENPDQLQTLRSDFELLP-----------------TAI 290 Query: 329 VEAMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWL 388 E +R R A LGG I AG ++ + RDP +D EFD R Sbjct: 291 EEIVRWTSPSPSKRRTASRAVSLGGQPIEAGQKVVVWEGSANRDPSVFDRADEFDITR-- 348 Query: 389 PERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRVGIT 448 F G C + + +L ++ L +++ +V + R Sbjct: 349 -------KPNPHLGFGQGVHYCLGANLARLELRVLFEELLSRFGSVRVVEPAEWTRSNRH 401 Query: 449 LRPHDLLV 456 L+V Sbjct: 402 TGIRHLVV 409 >4JBT-A nrPDB Length = 410 Score = 241 bits (615), Expect = 5e-64, Method: Composition-based stats. Identities = 96/429 (22%), Positives = 154/429 (35%), Gaps = 64/429 (14%) Query: 49 SQLRDHGDVVRIKLGPKTVYAVTNPELTGALALNPDYHIA------------GPLWESLE 96 S+LR G + RI L AVT L L + W + Sbjct: 24 SRLRAAGPLTRIDLLGVPALAVTGHTLARQLLTDTRLVKDINAWSLWQSGTVTRQWPLIG 83 Query: 97 GLLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQ----PGKTV 152 + + T +GP HRR R A + A P +E L + + G V Sbjct: 84 MIDVDRSMFTVDGPEHRRLRIKTTQALTRRRLDALKPTIERYVAELLDDLERAGADGAVV 143 Query: 153 DATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPA 212 D S F + + L G +++ +++ + + P Sbjct: 144 DLKS-VFAYPLPMRVISALMGVPSEDQ----------------EQLLTWYKAFFSILTPQ 186 Query: 213 NRRFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAIL 272 + R + ++H E++ RR + + DDL +AL+ A D P+ E+E+ + A++ Sbjct: 187 DERL-RVIDEMHGYFTEMV--RRKTAEPGDDLTSALIYATDGE-TPLTEEEVIGNLQALV 242 Query: 273 TPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAM 332 G ET S I+ ++AL HPE +RD I E + Sbjct: 243 AAGHETTVSLILTAVRALLSHPEQLRLVRDGEIGW-----------------ETAIEETL 285 Query: 333 RLR-PAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYD-DNLEFDPDRWLPE 390 R P + +L R A + +LG IP G ++ S AI RD + D +FD R Sbjct: 286 RWDGPVIHLLMRFATEDIDLGDAVIPRGEGVVMSYRAIGRDITVHGADADDFDITRATAA 345 Query: 391 RAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRVGITLR 450 R F G CP + + + AL T++ A D + L Sbjct: 346 R--------HISFGHGPHICPGAALARLEAAIALPALFTRFPHLHPALPLDQIPNLPVLT 397 Query: 451 PHDLLVRPV 459 +DL P+ Sbjct: 398 QNDLSHFPI 406 >4Z5P-A nrPDB Length = 400 Score = 236 bits (603), Expect = 1e-62, Method: Composition-based stats. Identities = 84/419 (20%), Positives = 154/419 (36%), Gaps = 56/419 (13%) Query: 48 MSQLRDHGDVVRIKLG-PKTVYAVTNPELTGALALNPDYH---IAGPLWESLEGLLGKEG 103 ++LR+ + R++L + VT + A +P + I + + Sbjct: 26 FAELRETDPLARVRLPYGGEGWMVTRYDDVRAANSDPRFSRAQIGEDTPRTTPLARRSDT 85 Query: 104 VATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQP-GKTVDATSESFRVA 162 + + + P H R RR + AF + A +EE L + + G D + Sbjct: 86 ILSLDPPEHTRLRRLLSKAFTARRMGAMQSWLEELFAGLLDGVERTGHPADIVRDL-AQP 144 Query: 163 VRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALAD 222 +A C L G ++R F+ ++ + A A Sbjct: 145 FTIAVICRLLGVPYEDRGR---------FQHWSEVIMSTTAY-------SKEEAVSADAS 188 Query: 223 LHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIAST 282 + + ++++ RRA+ DDLL L+ A+DD+ D + E E+ V +L G ET A Sbjct: 189 IRAYLADLVSARRAA--PHDDLLGVLVSARDDD-DRLTEDELITFGVTLLVAGHETSAHQ 245 Query: 283 IMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVL- 341 + ++ AL H + +R++ E + + E +R P + Sbjct: 246 LGNMVYALLTHEDQLSLLREQPELLP-----------------RAVEELLRFVPLGNGVG 288 Query: 342 -TRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAM 400 R A+ + EL G + AG ++ + RDP+++DD D R K Sbjct: 289 NARIALEDVELSGGTVRAGEGVVAAAVNANRDPRAFDDPDRLDITR---------EKNPH 339 Query: 401 KPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRV---GITLRPHDLLV 456 F G C + +L + L ++ ++A D V G+ P L + Sbjct: 340 LAFGHGAHYCLGAQLARMELRVAIGGLLERFPGLRLAVPADQVEWKTGGLFRGPQRLPI 398 >2ZBZ-A nrPDB Length = 412 Score = 236 bits (602), Expect = 1e-62, Method: Composition-based stats. Identities = 81/426 (19%), Positives = 133/426 (31%), Gaps = 56/426 (13%) Query: 44 PLAFMSQLRDHGDVVRIKLG-PKTVYAVTNPELTGALALNPDYHIAG--PLWESLEGLL- 99 P + G + R+ L + + VT E L +P + + Sbjct: 27 PDGYAQLRDTPGPLHRVTLYDGRQAWVVTKHEAARKLLGDPRLSSNRTDDNFPATSPAFE 86 Query: 100 ----GKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDAT 155 + + P H +RR F + I P +EE H + Sbjct: 87 AVRESPQAFIGLDPPEHGTRRRMTISEFTVKRIKGMRPEVEEVVHGFLDEMLAAGPTADL 146 Query: 156 SESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRR 215 F + V C L G + F+ +R+V L Sbjct: 147 VSQFALPVPSMVICRLLGVPYAD---------HEFFQDASKRLVQSTDAQSALT------ 191 Query: 216 FNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPG 275 A DL +D +I + + L+ AL+ + NG+ I +E+ + +L G Sbjct: 192 ---ARNDLAGYLDGLITQ--FQTEPGAGLVGALVADQLANGE-IDREELISTAMLLLIAG 245 Query: 276 SETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLR 335 ET AS + L DHPE +R + V G + E +R Sbjct: 246 HETTASMTSLSVITLLDHPEQYAALRADRSLVPG-----------------AVEELLRYL 288 Query: 336 PAV-WVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAAN 394 R A A+ E+ G I AG +I RD Y+D D R Sbjct: 289 AIADIAGGRVATADIEVEGQLIRAGEGVIVVNSIANRDGTVYEDPDALDIHR-------- 340 Query: 395 VPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRVGITLRPHDL 454 F G +C + + +L +I AL + ++A + + + + Sbjct: 341 -SARHHLAFGFGVHQCLGQNLARLELEVILNALMDRVPTLRLAVPVEQLVLRPGTTIQGV 399 Query: 455 LVRPVA 460 PV Sbjct: 400 NELPVT 405 >5IT1-A nrPDB Length = 399 Score = 236 bits (602), Expect = 1e-62, Method: Composition-based stats. Identities = 85/446 (19%), Positives = 148/446 (33%), Gaps = 74/446 (16%) Query: 8 PETRAPAAPGAPELREPPVAGGGVPLLGHGWRLARDPLAFMSQLRDHGDVVRIKL-GPKT 66 P APAAP A P L P ++ +R V R Sbjct: 4 PTAGAPAAPKA----------RSCPFL---------PPDGIADIRAAAPVTRATFTSGHE 44 Query: 67 VYAVTNPELTGALALNPDYHIAGPLWE-----SLEGLLGKEGVATANGPLHRRQRRTIQP 121 + VT E A+ +P + + P + G+ + + P H R+ + Sbjct: 45 AWLVTGYEQVRAVLRDPSFSVGVPHALHTQDGVVTQKPGRGSLLWQDAPEHTDDRKLLAK 104 Query: 122 AFRLDAIPAYGPIMEEEAHALTERWQP-GKTVDATSESFRVAVRVAARCLLRGQYMDERA 180 F + + A P ++ + + G VD F V L G + RA Sbjct: 105 EFTVRRMQALRPNIQRIVDEHLDAIEARGGPVDLVKT-FANPVPSMVISDLFGVPAERRA 163 Query: 181 ERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQK 240 E F+ + M+ A L L+ +++ ERRA+ Sbjct: 164 E---------FQEIAEAMMRVD--------QDAAATEAAGMRLGGLLYQLVQERRAN--P 204 Query: 241 PDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRI 300 DDL++AL+ +D +G I + + + +L +T A I L D P+ + Sbjct: 205 GDDLISALITTEDPDGV-IDDMFLMNAAGTLLIAAHDTTACMIGLGTALLLDRPDQLALL 263 Query: 301 RDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLT-RRAVAESELGGYRIPAG 359 + + + GN + E +R R A + E+GG RI G Sbjct: 264 QKDPSLI-----------------GNAVEELLRYLTIGQFGAERVATQDGEIGGVRIAKG 306 Query: 360 ADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQ 419 ++ + DP +D FD R F G +C + + Sbjct: 307 EQVVTHLLSADFDPAFVEDPERFDITR---------RPAPHLAFGFGAHQCIGQQLARIE 357 Query: 420 LTLITAALATKYRFEQVAGSNDAVRV 445 L ++ L ++ ++A + +R Sbjct: 358 LQIVFGTLFRRFPTLRLAKPVEELRF 383 >3ABB-A nrPDB Length = 408 Score = 236 bits (601), Expect = 2e-62, Method: Composition-based stats. Identities = 78/408 (19%), Positives = 140/408 (34%), Gaps = 55/408 (13%) Query: 44 PLAFMSQLRDHGDVVRIKLG-PKTVYAVTNPELTGALALNPDYHIAGPLWES---LEGLL 99 P + R + ++ L + + +T AL ++P + + Sbjct: 26 PPKAYEERRGESPLTQVTLFDGRPAWLITGHAEGRALLVDPRLSSDWGHPDFPVVVRRTE 85 Query: 100 GKEGVAT----ANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDAT 155 + G+A + P+H RQRR + P+F + + A P ++ L + Sbjct: 86 DRGGLAFPLIGVDDPVHARQRRMLIPSFGVKRMNAIRPRLQSLVDRLLDDMLAKGPGADL 145 Query: 156 SESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRR 215 +F + V A C L G + + F G Sbjct: 146 VSAFALPVPSVAICELLGVPYGDHD--FFEECSRNFVGAATSAEADAAF----------- 192 Query: 216 FNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPG 275 +L+ + ++ R + D LL L+ + + GD + E+ + +L G Sbjct: 193 -----GELYTYLHGLVG--RKQAEPEDGLLDELIARQLEEGD-LDHDEVVMIALVLLVAG 244 Query: 276 SETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLR 335 ET + I L HPE D + + AV+G V+ E +R Sbjct: 245 HETTVNAIALGALTLIQHPEQIDVLLRDPGAVSG-----------------VVEELLRFT 287 Query: 336 PAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANV 395 + R A + E+GG I AG ++ S + RD K+Y++ FD R Sbjct: 288 SVSDHIVRMAKEDIEVGGATIKAGDAVLVSITLMNRDAKAYENPDIFDARR--------- 338 Query: 396 PKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAV 443 F G +C + + A+L + L + ++A D V Sbjct: 339 NARHHVGFGHGIHQCLGQNLARAELEIALGGLFARIPGLRLAVPLDEV 386 >3R9C-A nrPDB Length = 418 Score = 235 bits (600), Expect = 2e-62, Method: Composition-based stats. Identities = 80/419 (19%), Positives = 138/419 (32%), Gaps = 50/419 (11%) Query: 41 ARDPLAFMSQLRDHGDVVRIKLGPKTVYAVTNPELTGALALNPDYHIAGPLWESLEGLL- 99 DP ++R G + L + ++ + +P + L Sbjct: 28 RADPYPIYDRIRRGGPL---ALPEANLAVFSSFSDCDDVLRHPSSCSDRTKSTIFQRQLA 84 Query: 100 --------GKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKT 151 G + P H R R + AF I P + L + G Sbjct: 85 AETQPRPQGPASFLFLDPPDHTRLRGLVSKAFAPRVIKRLEPEITALVDQLLDAV-DGPE 143 Query: 152 VDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLP 211 + + VA C L G +++ + + + + G L Sbjct: 144 FNLIDNL-AYPLPVAVICRLLGVPIEDEPK--FSRASALLAAALDPFLALTGETSDLFDE 200 Query: 212 ANRRFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAI 271 A L + +I ERR + +DL++ L+ A +++GD + E EI + Sbjct: 201 Q----MKAGMWLRDYLRALIDERRRT--PGEDLMSGLV-AVEESGDQLTEDEIIATCNLL 253 Query: 272 LTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEA 331 L G ET + I A+ P + + VI E Sbjct: 254 LIAGHETTVNLIANAALAMLRTPGQWAALAADGSR-----------------ASAVIEET 296 Query: 332 MRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPER 391 MR P V +++R A + +G + +P G ++ A RDP FDPDR Sbjct: 297 MRYDPPVQLVSRYAGDDLTIGTHTVPKGDTMLLLLAAAHRDPTIVGAPDRFDPDR----- 351 Query: 392 AANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRVGITLR 450 + F G C + + T+ ALA ++ +++G + R +TLR Sbjct: 352 ----AQIRHLGFGKGAHFCLGAPLARLEATVALPALAARFPEARLSGEPEYKR-NLTLR 405 >6A7J-A nrPDB Length = 411 Score = 235 bits (598), Expect = 5e-62, Method: Composition-based stats. Identities = 104/438 (23%), Positives = 170/438 (38%), Gaps = 65/438 (14%) Query: 40 LARDPLAFMSQLRDHGDVVRIKL-GPKTVYAVTNPELTGALALNPDYHIAGPLWESLE-- 96 RD + LR G + ++L G VYAVT+ + AL + +W + + Sbjct: 11 FVRDLDGESAALRAAGPLAEVELPGGVHVYAVTHHKEARALLTDSRVVKDINVWNAWQRG 70 Query: 97 ------GLLG----KEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERW 146 L+G + T +GP HRR R + A + + +E +A ER Sbjct: 71 EIPADWPLIGLVNPGRSMLTVDGPDHRRLRTLVAQALTVKRVEKLRAGIEALTNASLERL 130 Query: 147 QP---GKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLG 203 G+ VD +E F + + L G + L +F + P Sbjct: 131 AALPAGEPVDLKAE-FAYPLPMNVISELMGVDAADHPR-----LKELFEKFFSTQTPP-- 182 Query: 204 PLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQE 263 +ADL L +I+ E++A+ DDL +AL+ A ++GD + ++E Sbjct: 183 ----------EEVPQMMADLGTLFTKIVEEKKAN--PGDDLTSALIAAS-EDGDHLTDEE 229 Query: 264 IHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRH 323 I + + I+ G ET S I+ +++ALA HPE ++ ++G P Sbjct: 230 ILNTLQLIIAAGHETTISLIVNVVEALAIHPEQRKKV------LSGEIP----------- 272 Query: 324 TGNVIVEAMRL-RPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSY-DDNLE 381 VI E +R P VL R A + E+G +P G ++ S A+ RD + Y + Sbjct: 273 WEGVIEETLRWNTPTSHVLIRFATEDIEVGDKVLPKGEGLVVSFGALGRDEEQYGPTAGD 332 Query: 382 FDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSND 441 FD R F G CP S + + AL ++ +A Sbjct: 333 FDATR---------TPNRHIAFGHGPHVCPGAALSRLEAGIALPALYERFPELDLAVPAA 383 Query: 442 AVRVGITLRPHDLLVRPV 459 +R + +DL PV Sbjct: 384 ELRNKPIVTQNDLHDLPV 401 >5EX6-C nrPDB Length = 434 Score = 233 bits (593), Expect = 1e-61, Method: Composition-based stats. Identities = 84/428 (19%), Positives = 146/428 (34%), Gaps = 67/428 (15%) Query: 36 HGWRLARDPLAFMSQLRDHGDVVRIKLGP----KTVYAVTNPELTGALALNPDYHIAGPL 91 H R DP +LR G++ R++LG + + T ++ + + Sbjct: 46 HTLRQGFDPA---DELRAAGELTRVRLGSGADAEHTWLATGHDVVRQVLGDHTRFSTRRR 102 Query: 92 WESLEGLLGKEG---------VATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEA-HA 141 ++ + + GK + + P H R RR + P F I P +E+ Sbjct: 103 FDRNDEIGGKGVFRPRELVGNLMDYDPPEHTRLRRLLAPGFTHRKIRRMAPYIEQIVTER 162 Query: 142 LTERWQPGKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVP 201 L E + G D E F V C L G D+RA +F + R + Sbjct: 163 LDEMEREGSPADLI-ELFADEVPGPVLCELLGVPRDDRA---------MFLQLCHRHL-- 210 Query: 202 LGPLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGE 261 + RR A + ++A R P D L ++ A ++GD + + Sbjct: 211 ------DASLSGRRRAAAGEAFSRYLVTMVARERKD---PGDGLIGMVVA--EHGDTVTD 259 Query: 262 QEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKL 321 +E+ V ++ G + I+ I + AL +PE +R +V Sbjct: 260 EELRGVCVQMMLAGDDNISGMIGLGVLALLRNPEQIAALRGDV----------------- 302 Query: 322 RHTGNVIVEAMRLRP-AVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNL 380 + E +R R A+ +S +G I AG ++ S RDP D Sbjct: 303 PAAERAVDELIRYLTVPYAPTPRTAIEDSTVGDQVIKAGETVLCSLPTANRDPALLPDAD 362 Query: 381 EFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSN 440 D R F G C + +L + AL ++ ++A + Sbjct: 363 RLDVTR---------EAVPHVAFGHGVHHCLGAALARLELRIAYTALWRRFPDLRLADPD 413 Query: 441 DAVRVGIT 448 A ++ Sbjct: 414 GATEFRLS 421 >2Z36-A nrPDB Length = 413 Score = 233 bits (593), Expect = 2e-61, Method: Composition-based stats. Identities = 73/414 (17%), Positives = 133/414 (32%), Gaps = 62/414 (14%) Query: 44 PLAFMSQLRDHGDVVRIKL-GPKTVYAVTNPELTGALA----LNPDYHIAGPLWESLEGL 98 P A +LR+ + +++L + V+ E A+ + D G +L+ Sbjct: 24 PPAAYERLRERAPINKVRLTSGGQAWWVSGHEEARAVLADGRFSSDKRKDGFPLFTLDAA 83 Query: 99 L------GKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERW--QPGK 150 + +G H RR + F + + A P +++ + + Sbjct: 84 TLQQLRSQPPLMLGMDGAEHSAARRPVIGEFTVKRLAALRPRIQDIVDHFIDDMLATDQR 143 Query: 151 TVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPL 210 VD + V C L G + F+ MV Sbjct: 144 PVDLVQAL-SLPVPSLVICELLGVPYTDHD---------FFQSRTTMMVS---------R 184 Query: 211 PANRRFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVA 270 + A A+L +D++I R + DDL + + + G + + Sbjct: 185 TSMEDRRRAFAELRAYIDDLIT--RKESEPGDDLFSRQIARQRQEGT-LDHAGLVSLAFL 241 Query: 271 ILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVE 330 +LT G ET A+ I + L HPE ++ + E Sbjct: 242 LLTAGHETTANMISLGVVGLLSHPEQLTVVKANPGRTP-----------------MAVEE 284 Query: 331 AMRLRPAV-WVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLP 389 +R V +R A + E+GG I AG +I S + DP + D D +R Sbjct: 285 LLRYFTIADGVTSRLATEDVEIGGVSIKAGEGVIVSMLSANWDPAVFKDPAVLDVER--- 341 Query: 390 ERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAV 443 F G +C + + +L ++ L + ++A + V Sbjct: 342 ------GARHHLAFGFGPHQCLGQNLARMELQIVFDTLFRRIPSLRLAVPMEDV 389 >1GWI-A nrPDB Length = 411 Score = 232 bits (592), Expect = 2e-61, Method: Composition-based stats. Identities = 92/435 (21%), Positives = 152/435 (34%), Gaps = 60/435 (13%) Query: 40 LARDPLAFMSQLRDHGDVVRIKL-GPKTVYAVTNPELTGALALNPDYHIAGPLWESLE-- 96 D ++LR G + ++L G V+AVT+ AL +P +W + Sbjct: 15 FVTDLDGESARLRAAGPLAAVELPGGVPVWAVTHHAEAKALLTDPRLVKDINVWGAWRRG 74 Query: 97 ------GLLG----KEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERW 146 L+G + T +G HRR R + A + + + E L + Sbjct: 75 EIPADWPLIGLANPGRSMLTVDGAEHRRLRTLVAQALTVRRVEHMRGRITELTDRLLDEL 134 Query: 147 QPGKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLY 206 V +F + + L G E L +F + P Sbjct: 135 PADGGVVDLKAAFAYPLPMYVVADLMGIE-----EARLPRLKVLFEKFFSTQTPP----- 184 Query: 207 RLPLPANRRFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHD 266 L +L ++ + +A +RA+ DDL +AL++A +NGD + + EI Sbjct: 185 -------EEVVATLTELASIMTDTVAAKRAA--PGDDLTSALIQAS-ENGDHLTDAEIVS 234 Query: 267 QVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGN 326 + ++ G ET S I+ + L+ HPE + Sbjct: 235 TLQLMVAAGHETTISLIVNAVVNLSTHPEQRALVLSGEAEW-----------------SA 277 Query: 327 VIVEAMRLRPA-VWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSY-DDNLEFDP 384 V+ E +R VL R A + +G IPAG +I S A+ RD +++ FD Sbjct: 278 VVEETLRFSTPTSHVLIRFAAEDVPVGDRVIPAGDALIVSYGALGRDERAHGPTADRFDL 337 Query: 385 DRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVR 444 R R F G CP S + + AL ++ +A +R Sbjct: 338 TRTSGNR--------HISFGHGPHVCPGAALSRMEAGVALPALYARFPHLDLAVPAAELR 389 Query: 445 VGITLRPHDLLVRPV 459 + +DL PV Sbjct: 390 NKPVVTQNDLFELPV 404 >3SN5-A nrPDB Length = 491 Score = 231 bits (589), Expect = 4e-61, Method: Composition-based stats. Identities = 95/473 (20%), Positives = 160/473 (33%), Gaps = 57/473 (12%) Query: 23 EPPVAGGGVPLLGHGWRLARDPLAFMS-QLRDHGDVVRIKLGPKTVYAVTNPELTGALAL 81 EPP+ G +P LG + +PL F+ R HG V KL K V+ +TNP + Sbjct: 14 EPPLENGLIPYLGCALQFGANPLEFLRANQRKHGHVFTCKLMGKYVHFITNPLSYHKVLC 73 Query: 82 NPDYHIAGPLWESLEG-LLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAH 140 + Y +L G + +G T + A+ + M E Sbjct: 74 HGKYFDWKKFHFALSAKAFGHRSIDPMDGNTTENINDTFIKTLQGHALNSLTESMMENLQ 133 Query: 141 ALTE-------RWQPGKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATV--- 190 + + T S +RV A + G+ + R + L + Sbjct: 134 RIMRPPVSSNSKTAAWVTEGMYSFCYRVMFE-AGYLTIFGRDLTRRDTQKAHILNNLDNF 192 Query: 191 --FRGMYRRMVVPLG-PLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQKPDDLLTA 247 F ++ +V L ++R A + ++L +L E I+E + +D L+ Sbjct: 193 KQFDKVFPALVAGLPIHMFRTAHNAREKLAESLRHENLQKRESISELISLRMFLNDTLST 252 Query: 248 LLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAV 307 + E + +L W L + +PE +EV+ Sbjct: 253 -----------FDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRT 301 Query: 308 TGGRPVAFE-----------DVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESEL----G 352 ++ L ++I E++RL A + R A + L G Sbjct: 302 LENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNI-RTAKEDFTLHLEDG 360 Query: 353 GYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVP---------KYAMKPF 403 Y I I P + DP+ Y D L F DR+L E KY PF Sbjct: 361 SYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPF 420 Query: 404 SAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSN-----DAVRVGITLRP 451 +G CP F++ ++ + + + E + G D R G+ + P Sbjct: 421 GSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQSRAGLGILP 473 >6GMF-A nrPDB Length = 397 Score = 231 bits (589), Expect = 5e-61, Method: Composition-based stats. Identities = 81/424 (19%), Positives = 149/424 (35%), Gaps = 50/424 (11%) Query: 42 RDPLAFMSQLRDHGDVVRIKLGPKTVYAVTNPELTGALALNPDYHIAGPLWESLEGLL-- 99 R+P A ++LR V R++ P+ AV + + + SL + Sbjct: 14 RNPYALFAELRRTSAVGRLQ--PQGFMAVGRYQDVARVLHDAKGFSNRGWAASLPRGVKW 71 Query: 100 ---GKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDATS 156 + + P H + R + AF + P + + AH L + + T +AT Sbjct: 72 DTSMPPSIVQVDPPRHGKLRTLVTKAFTPRTVAQLEPRIRDIAHELVDGLRGKSTFEATV 131 Query: 157 ESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRF 216 E V + + + G + RA+ F+ MV G L + + + Sbjct: 132 EVT-VPMPMIVIAEMLGVAPERRAD---------FKRWSDDMV---GSLALVRVGNAAQL 178 Query: 217 NDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGS 276 + + + E++ E + +DL++ LL A+ D G+ + E+ +L G+ Sbjct: 179 ERSTQEFYAYFSEVLEE--RRREPREDLISQLLAAEVD-GEKLTAGEVLSFANTLLIAGN 235 Query: 277 ETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRP 336 ET S I L AL DHPE + ++ V V+ E +R Sbjct: 236 ETTTSLIGNALVALTDHPEQLAAAQADLSLVP-----------------AVVEEVLRYES 278 Query: 337 AVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVP 396 + R+ + + E+G RIPA + ++ + RD + D FD R Sbjct: 279 PAQCIFRQTMTDVEIGDERIPARSVVLPLLASANRDESRFPDPDRFDIHR---------D 329 Query: 397 KYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKY-RFEQVAGSNDAVRVGITLRPHDLL 455 F C + + ++ L + ++V+ P L Sbjct: 330 TKGHLAFGLDIHFCIGAPLARLEAKVMLEVLLARLGDIQRVSQEVSWSPSFFIRSPSTLP 389 Query: 456 VRPV 459 +R Sbjct: 390 LRAT 393 >3K9V-A nrPDB Length = 482 Score = 230 bits (587), Expect = 9e-61, Method: Composition-based stats. Identities = 97/453 (21%), Positives = 171/453 (37%), Gaps = 35/453 (7%) Query: 26 VAGGGVPLLGHGWR------LARDPLAFMSQLRDHGDVVRIKLGPKTVYAVTNPELTGAL 79 PLLG L + + +G + R+KLG + +P L AL Sbjct: 27 PGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHLGSPSLLEAL 86 Query: 80 ALNPDYHIAG----PLWESLEGLLGKEGVATANGPLHRRQRRTIQPAF-RLDAIPAYGPI 134 H P + G+ G +R R Q + I Sbjct: 87 YRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMKLDKK 146 Query: 135 MEEEAHALTERW-----QPGKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALAT 189 + E ER + G+ D SE + + + CL+ + ++ A Sbjct: 147 INEVLADFLERMDELCDERGRIPDLYSELNKWSFE--SICLVLYEKRFGLLQKETEEEAL 204 Query: 190 VFRGMYRRMVVPLGPLYRLPLPANRRFNDALADLHLLVDEIIAE----------RRASGQ 239 F + M+ G + P+ ++R N + H L + I + +R S Q Sbjct: 205 TFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQRYSQQ 264 Query: 240 KPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADR 299 D L + + D + ++E++ V + ET A+++MW+L L+ +P+ R Sbjct: 265 PGADFLCDIYQQ-----DHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRR 319 Query: 300 IRDEVEAV-TGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESELGGYRIPA 358 + EV++V + ED+R + + + E+MRL P+V TR + LG Y +P Sbjct: 320 LLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPK 379 Query: 359 GADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMA 418 G + + + +++D+ +F P+RWL ++ + +A PF GKR C + Sbjct: 380 GTVLTLNTQVLGSSEDNFEDSHKFRPERWL-QKEKKINPFAHLPFGIGKRMCIGRRLAEL 438 Query: 419 QLTLITAALATKYRFEQVAGSNDAVRVGITLRP 451 QL L + KY + L P Sbjct: 439 QLHLALCWIIQKYDIVATDNEPVEMLHLGILVP 471 >5NWS-A nrPDB Length = 435 Score = 230 bits (586), Expect = 1e-60, Method: Composition-based stats. Identities = 90/428 (21%), Positives = 141/428 (32%), Gaps = 66/428 (15%) Query: 40 LARDPLAFMSQLRDHGDVVRIKLG-PKTVYAVTNPELTGALALNPDYHIAGPLWESLEGL 98 L DP +LR+ G VVR + V+ VT + A+ +P + G Sbjct: 32 LLADPFTGYGRLRERGPVVRGRFVDGTPVWFVTRYDDVRAVLRDPRFVNTPSPVPGEGGA 91 Query: 99 LGKEG------------------VATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAH 140 +EG + ++ P H R RR + AF I P +E A Sbjct: 92 DPREGMMDLLNVPEPLRVYLLGSILDSDPPDHPRLRRLVTRAFAARRILGLRPGIERIAD 151 Query: 141 ALTERWQPGKTVDATSES---FRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRR 197 L + D T + F + + C L G + ER + Sbjct: 152 RLLAELPRREEEDGTVDLLEHFAYPLSITVICELVGIPATDL-ERWREWGGDLVS----- 205 Query: 198 MVVPLGPLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGD 257 R + + +I +RRA+ DDLL+ L+ A+DD+G Sbjct: 206 -------------MRPERLRHSFPVMIDYCHRLIEQRRAAL--TDDLLSELIRAQDDDGG 250 Query: 258 PIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFED 317 + + E ++ ++ G ET A I AL HP +R + + Sbjct: 251 RLSDIETVTMILTLVLAGHETSAHLIGNGTAALLTHPGQWALLRKDPALLP--------- 301 Query: 318 VRKLRHTGNVIVEAMRLRPAVWVLT-RRAVAESELGGYRIPAGADIIYSPYAIQRDPKSY 376 + E MR +V V R A + EL G + G + + DP+ Y Sbjct: 302 --------RAVHELMRWCGSVHVARLRYATEDLELAGTPVARGDAVQLVLVSANFDPRHY 353 Query: 377 DDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQV 436 D D R +A N F G C + + + A L Y + Sbjct: 354 SDPDRLDITRHQEGQAEN-----HVGFGHGIHYCLGATLARQEGEVALARLLETYPDLAL 408 Query: 437 AGSNDAVR 444 A + VR Sbjct: 409 ADGDPEVR 416 >4MM0-A nrPDB Length = 399 Score = 229 bits (585), Expect = 1e-60, Method: Composition-based stats. Identities = 77/383 (20%), Positives = 135/383 (35%), Gaps = 47/383 (12%) Query: 64 PKTVYAVTNPELTGALALNPDYHIAGPLWESLE-GLLGKEGVATANGPLHRRQRRTIQPA 122 + VT E + +P + + L + + E V T + P+H R RR + Sbjct: 44 GDPGFLVTRYEDVRFVLSDPRFSVRQDLPGAPRLTEMTFESVMTTDPPVHTRLRRLLSRD 103 Query: 123 FRLDAIPAYGPIMEEEAHALTERWQPGKTVDATSESFRVAVRVAARCLLRGQYMDERAER 182 F I P +EE A L + + ES V + C L G M + A Sbjct: 104 FTARRIERMRPRLEEIAEGLLDEMEKKGAPADIVESLAVPFPITVICELLGVPMVDVAR- 162 Query: 183 LCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQKPD 242 FRG MV G + + A L +D ++A +R + Sbjct: 163 --------FRGWADTMVSLTGY-------SMEDWTAARDALESYLDGLVAAKREN--PGS 205 Query: 243 DLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRD 302 DLL+AL+ ++ + + + ++ + +L G E ++ + + L P+ +R Sbjct: 206 DLLSALVATAAED-NELTDHDVRSLSLILLLAGYEPASNQLGSSVLTLLRFPDRLAELRR 264 Query: 303 EVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAV-WVLTRRAVAESELGGYRIPAGAD 361 + + + + E MR PA L R + + +G IPA + Sbjct: 265 DPGLLP-----------------SAVEELMRYAPAGDGALFRVTLEDVTIGDTHIPANSA 307 Query: 362 IIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLT 421 ++ S A DP+ +DD DR P G C + +L Sbjct: 308 VLASTQAANWDPRRFDDPTGLRLDR---------PDNQHTALGHGIHFCLGAALARVELQ 358 Query: 422 LITAALATKYRFEQVAGSNDAVR 444 + AL ++ +A +R Sbjct: 359 VAIGALLRRFPRLALATDESGLR 381 >6A7I-A nrPDB Length = 411 Score = 229 bits (584), Expect = 2e-60, Method: Composition-based stats. Identities = 102/438 (23%), Positives = 161/438 (36%), Gaps = 65/438 (14%) Query: 40 LARDPLAFMSQLRDHGDVVRIKL-GPKTVYAVTNPELTGALALNPDYHIAGPLWESLE-- 96 RD + LR G + ++L G VYAVT AL + +W + Sbjct: 11 FVRDLDGESAALRAAGPLAEVELPGGVHVYAVTRHAEARALLTDSRVVKDIDVWNAWRRG 70 Query: 97 ------GLLG----KEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERW 146 L+G + T +G HRR R + A + + +E +A E+ Sbjct: 71 EIPMDWPLIGLANPGRSMLTVDGADHRRLRTLVAQALTVKRVERLRAGIEALTNASLEKL 130 Query: 147 QP---GKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLG 203 G+ VD +E F + + L G + L +F + P Sbjct: 131 AALPAGEPVDLKAE-FAYPLPMNVISELMGVDAADHPR-----LKELFEKFFSTQTPP-- 182 Query: 204 PLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQE 263 +ADL L +I+ +R + DDL +AL+ A +NGD + ++E Sbjct: 183 ----------EEVPQMMADLGALFTKIVDAKRTN--PGDDLTSALIAAS-ENGDHLTDEE 229 Query: 264 IHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRH 323 I + + I+ G ET S I+ +++AL HPE ++ + G Sbjct: 230 IVNTLQLIIAAGHETTISLIVNVVEALQTHPEQRKKVLNGEIGWDG-------------- 275 Query: 324 TGNVIVEAMRL-RPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSY-DDNLE 381 VI E +R P VL R A + E+G +P G +I S A+ RD + Y E Sbjct: 276 ---VIEETLRWNTPTSHVLIRFATEDIEVGDKILPKGEGLIISFGALGRDEEQYGPTAGE 332 Query: 382 FDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSND 441 FD R F G CP S + + AL ++ +A Sbjct: 333 FDATR---------TPNRHIAFGHGPHVCPGAALSRLEAGIALPALYERFPELDLAVPAS 383 Query: 442 AVRVGITLRPHDLLVRPV 459 +R + +DL PV Sbjct: 384 DLRNKPIVTQNDLHELPV 401 >4WPZ-A nrPDB Length = 397 Score = 228 bits (581), Expect = 4e-60, Method: Composition-based stats. Identities = 83/393 (21%), Positives = 143/393 (36%), Gaps = 56/393 (14%) Query: 64 PKTVYAVTNPELTGALALNPDYHI------AGPLWESLEGLLGKEGVATANGPLHRRQRR 117 + + VT + ++ + A + E+ G L E + + P H R R+ Sbjct: 36 GISGWMVTKHADVRKVLVDSRFSSKVMATAAAAMSETETGKLMNESLVGMDAPEHTRLRK 95 Query: 118 TIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDATSESFRVAVRVAARCLLRGQYMD 177 + AF + P + E L + + ++F V + V C L G Sbjct: 96 LVTKAFTARRVETLRPRITELVGQLLDELETLPRPVDLVKNFSVPLPVRVICELLGVPAG 155 Query: 178 ERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALADLHLLVDEIIAERRAS 237 ++ A + G ++++V A L E+IA +R + Sbjct: 156 DQDT--FHAWSNALLGDWQQVV---------------EKEAATVSLVNYFGELIAVKREN 198 Query: 238 GQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHA 297 DDL++ L+ A D + E+EI + IL+ G ET A+ I L L +PE Sbjct: 199 --PADDLISELI-AISDGDSTLTEREIIALSIGILSAGHETTANQISMFLVTLLHNPEEL 255 Query: 298 DRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWV---LTRRAVAESEL-GG 353 D++RD EA+ + E +R P + R AE EL GG Sbjct: 256 DKLRDNREAIPK-----------------AVDELLRFVPLTTTGGIIPRLTTAEVELSGG 298 Query: 354 YRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSD 413 +PAGA ++ + RDP+ ++D + R F AG C Sbjct: 299 QVLPAGAVVLPAVATANRDPEVFEDGERLNVTR---------ENNPHLAFGAGIHHCLGA 349 Query: 414 HFSMAQLTLITAALATKYRFEQVAGSNDAVRVG 446 + +L A+ + ++A +R+ Sbjct: 350 QLARIELQEALGAILDRMPQVRLAVPESELRLK 382 >1CPT-A nrPDB Length = 428 Score = 228 bits (580), Expect = 6e-60, Method: Composition-based stats. Identities = 76/429 (17%), Positives = 149/429 (34%), Gaps = 48/429 (11%) Query: 45 LAFMSQLRDHGDVVRIKL-GPKTVYAVTNPELTGALALNPDYH---------IAGPLWES 94 LRD + + G ++ T + P Sbjct: 28 YPAFKWLRDEQPLAMAHIEGYDPMWIATKHADVMQIGKQPGLFSNAEGSEILYDQNNEAF 87 Query: 95 LEGLLGK-----EGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQP- 148 + + G + + + + P H R F+ +I + A A +R Sbjct: 88 MRSISGGCPHVIDSLTSMDPPTHTAYRGLTLNWFQPASIRKLEENIRRIAQASVQRLLDF 147 Query: 149 GKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRL 208 D ++ + + G D+ L + L F G++ + + Sbjct: 148 DGECDFMTDC-ALYYPLHVVMTALGVPEDDEP--LMLKLTQDFFGVHEPDEQAVAAPRQS 204 Query: 209 PLPANRRFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQV 268 A RRF++ +A + + +RR+ DD+++ L +K D G+ I ++ I+ Sbjct: 205 ADEAARRFHETIATFYDYFNGFTVDRRSC--PKDDVMSLLANSKLD-GNYIDDKYINAYY 261 Query: 269 VAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVI 328 VAI T G +T +S+ + L+ +PE + + + ++ Sbjct: 262 VAIATAGHDTTSSSSGGAIIGLSRNPEQLALAKSDPALIP-----------------RLV 304 Query: 329 VEAMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWL 388 EA+R V R A+A++E+ G I G I+ S + RD + + + EFD R+ Sbjct: 305 DEAVRWTAPVKSFMRTALADTEVRGQNIKRGDRIMLSYPSANRDEEVFSNPDEFDITRF- 363 Query: 389 PERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRVGIT 448 F G C H + ++ + L K + +++G V Sbjct: 364 --------PNRHLGFGWGAHMCLGQHLAKLEMKIFFEELLPKLKSVELSGPPRLVATNFV 415 Query: 449 LRPHDLLVR 457 P ++ +R Sbjct: 416 GGPKNVPIR 424 >4XE3-A nrPDB Length = 407 Score = 227 bits (579), Expect = 7e-60, Method: Composition-based stats. Identities = 85/428 (19%), Positives = 145/428 (33%), Gaps = 60/428 (14%) Query: 25 PVAGGGVPLLGHGWRLARDPLAFMSQLRDHGDVVRIKL--GPKTVYAVTNPELTGALALN 82 P +P H L DP ++LR V R++L G T + VT + + Sbjct: 15 PAYPFSLP---HALDL--DPH--YAELRRDEPVSRVRLPYGEGTAWLVTRMSDARIVLGD 67 Query: 83 PDYHIAGPLWESLEGLL----GKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEE 138 + A + + +GV + P H R RR + AF + P + Sbjct: 68 SRFSTAAATDPATPRMFPTPPEPDGVLAQDPPDHTRLRRLVGKAFTARRVEEMRPRVRSL 127 Query: 139 AHALTERWQPGKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRM 198 +L + + E V VA C L G +++R +FR M Sbjct: 128 VDSLLDDMVAHGSPADLVEFLAVPFPVAVICELLGVPLEDRD---------LFRTFSDAM 178 Query: 199 VVPLGPLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDP 258 + D + +D ++A+RR + +DLL AL A D++ D Sbjct: 179 LSST-------RLTAAEIQRVQQDFMVYMDGLVAQRRDA--PTEDLLGALALATDND-DH 228 Query: 259 IGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDV 318 + + EI + V++L G ET + I L+ L + + + + V Sbjct: 229 LTKGEIVNMGVSLLIAGHETSVNQITNLVHLLLTERKRYESLVADPALVP---------- 278 Query: 319 RKLRHTGNVIVEAMRLRPAVW--VLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSY 376 + E +R P V R A + EL + AG + + RD + + Sbjct: 279 -------AAVEEMLRYTPLVSAGSFVRVATEDVELSTVTVRAGEPCVVHFASANRDEEVF 331 Query: 377 DDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQV 436 D E D R + F G C +L +AL ++ + Sbjct: 332 DHADELDFHR---------ERNPHIAFGHGAHHCIGAQLGRLELQEALSALVRRFPTLDL 382 Query: 437 AGSNDAVR 444 A ++ Sbjct: 383 AEPVAGLK 390 >3ABA-A nrPDB Length = 403 Score = 226 bits (577), Expect = 1e-59, Method: Composition-based stats. Identities = 84/446 (18%), Positives = 144/446 (32%), Gaps = 72/446 (16%) Query: 8 PETRAPAAPGAPELREPPVAGGGVPLLGHGWRLARDPLAFMSQLRDHGDVVRIKL-GPKT 66 PE A A P P+ R P ++ +R V R Sbjct: 2 PEPTADA-PTVPKARSCPFLPP----------------DGIADIRAAAPVTRATFTSGHE 44 Query: 67 VYAVTNPELTGALALNPDYHIAGPLWESLEGLL-----GKEGVATANGPLHRRQRRTIQP 121 + VT E AL + + + P + + G+ + + P H R+ + Sbjct: 45 AWLVTGYEEVRALLRDSSFSVQVPHALHTQDGVVTQKPGRGSLLWQDEPEHTSDRKLLAK 104 Query: 122 AFRLDAIPAYGPIMEEEAHALTERWQP-GKTVDATSESFRVAVRVAARCLLRGQYMDERA 180 F + + A P ++ + + G VD F AV L G + ER Sbjct: 105 EFTVRRMQALRPNIQRIVDEHLDAIEARGGPVDLVKT-FANAVPSMVISDLFGVPV-ERR 162 Query: 181 ERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQK 240 + R A L L+ +++ ERRA+ Sbjct: 163 AEFQDIAEAMMRVDQDAAAT----------------EAAGMRLGGLLYQLVQERRAN--P 204 Query: 241 PDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRI 300 DDL++AL+ +D +G + + + + +L +T A I L D P+ + Sbjct: 205 GDDLISALITTEDPDGV-VDDMFLMNAAGTLLIAAHDTTACMIGLGTALLLDSPDQLALL 263 Query: 301 RDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVL-TRRAVAESELGGYRIPAG 359 R++ V GN + E +R R A + ELGG RI G Sbjct: 264 REDPSLV-----------------GNAVEELLRYLTIGQFGGERVATRDVELGGVRIAKG 306 Query: 360 ADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQ 419 ++ A DP ++ FD R F G +C + + Sbjct: 307 EQVVAHVLAADFDPAFVEEPERFDITR---------RPAPHLAFGFGAHQCIGQQLARIE 357 Query: 420 LTLITAALATKYRFEQVAGSNDAVRV 445 L ++ L + ++A + +R Sbjct: 358 LQIVFETLFRRLPGLRLAKPVEELRF 383 >2WIO-A nrPDB Length = 431 Score = 224 bits (572), Expect = 5e-59, Method: Composition-based stats. Identities = 76/410 (18%), Positives = 137/410 (33%), Gaps = 45/410 (10%) Query: 51 LRDHGDVVRIKLGPKTVYAVTNPELTGALALNPDYHIAGPLWESLEGLLGKEGVATANGP 110 +R+ V + + G V+ V + + + P + + P Sbjct: 57 MREKQPVWQDRYG---VWHVFRHADVQTVLRDTATFSSDPTRVIEGASPTPGMIHEIDPP 113 Query: 111 LHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDATSESFRVAVRVAARCL 170 HR R+ + AF I P + + +L G++ D + + V Sbjct: 114 EHRALRKVVSSAFTPRTISDLEPRIRDVTRSLLAD--AGESFDLV-DVLAFPLPVTIVAE 170 Query: 171 LRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALADLHLLVDEI 230 L G + + G + +V + R D L L + Sbjct: 171 LLGLPPMDHEQF----------GDWSGALVDIQMDDPTDPALAERIADVLNPLTAYLKAR 220 Query: 231 IAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQAL 290 AERRA DDL++ L+ A+ D G + ++E + A+L G T + +++ L Sbjct: 221 CAERRA--DPGDDLISRLVLAEVD-GRALDDEEAANFSTALLLAGHITTTVLLGNIVRTL 277 Query: 291 ADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESE 350 +HP H D ++ + ++ E +R RP + R +E Sbjct: 278 DEHPAHWDAAAEDPGRIP-----------------AIVEEVLRYRPPFPQMQRTTTKATE 320 Query: 351 LGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKC 410 + G IPA + + RD ++DD FDP R A F G C Sbjct: 321 VAGVPIPADVMVNTWVLSANRDSDAHDDPDRFDPSR-------KSGGAAQLSFGHGVHFC 373 Query: 411 PSDHFSMAQLTLITAALATKYRFEQVAGSNDAVR--VGITLRPHDLLVRP 458 + + + + ++ V ++ +R I L L V Sbjct: 374 LGAPLARLENRVALEEIIARFGRLTVDRDDERLRHFEQIVLGTRHLPVLA 423 >5DQN-A nrPDB Length = 426 Score = 224 bits (570), Expect = 8e-59, Method: Composition-based stats. Identities = 83/438 (18%), Positives = 148/438 (33%), Gaps = 61/438 (13%) Query: 25 PVAGGGVPLLGHGWRLARDPLAFMSQLRDHGDVVRIKLGPKTV-------YAVTNPELTG 77 P L L R P+ +++LR + + + T + VT Sbjct: 4 PNIPSDFDFLDATLNLERLPVEELAELRKSEPIHWVDVPGGTGGFGDKGYWLVTKHADVK 63 Query: 78 ALALNPDYHIAGPL---------WESLEGLLGKEGVATANGPLHRRQRRTIQPAFRLDAI 128 ++ D + P L + + + P H R R+ I F AI Sbjct: 64 EVSRRSDVFGSSPDGAIPVYPQDMTREAVDLQRAVLLNMDAPQHTRLRKIISRGFTPRAI 123 Query: 129 PAYGPIMEEEAHALTERWQPGKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALA 188 + A + + D + + + A L G D+R + Sbjct: 124 GRLEDELRSRAQKIAQTAAAQGAGDFVEQVSC-ELPLQAIAELLGVPQDDRDKLFR---- 178 Query: 189 TVFRGMYRRMVVPLGPLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQKPDDLLTAL 248 M P Y PA F +L ++ ER + +D++T L Sbjct: 179 -----WSNEMTAGEDPEYADVDPAMSSF-----ELISYAMKMAEER--AVNPTEDIVTKL 226 Query: 249 LEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVT 308 +EA D +G+ + + E VV + G+ET ++I + A A +P+ + + E Sbjct: 227 IEA-DIDGEKLSDDEFGFFVVMLAVAGNETTRNSITHGMIAFAQNPDQWELYKKE----- 280 Query: 309 GGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYA 368 RP D E +R V R A+ + ELGG +I G ++ S + Sbjct: 281 --RPETAAD------------EIVRWATPVSAFQRTALEDVELGGVQIKKGQRVVMSYRS 326 Query: 369 IQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALA 428 D + ++D F+ R P + G C + + + LI A+A Sbjct: 327 ANFDEEVFEDPHTFNILR--------SPNPHVGFGGTGAHYCIGANLARMTINLIFNAIA 378 Query: 429 TKYRFEQVAGSNDAVRVG 446 + G+ + ++ G Sbjct: 379 DNMPDLKPIGAPERLKSG 396 >5FOI-A nrPDB Length = 408 Score = 222 bits (566), Expect = 2e-58, Method: Composition-based stats. Identities = 75/386 (19%), Positives = 131/386 (33%), Gaps = 52/386 (13%) Query: 64 PKTVYAVTNPELTGALALNPDYHIAGPLWESLEGLLGKE----GVATANGPLHRRQRRTI 119 + V+ E AL ++P + L G + + P H R RR Sbjct: 55 GSPTWLVSRYEHVRALLVDPRVTVDPTRQPRLSEADGDGDGFRSMLMLDPPEHTRLRRMF 114 Query: 120 QPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDATSESFRVAVRVAARCLLRGQYMDER 179 AF + + P +E+ + +R + + + C L G ++R Sbjct: 115 ISAFSVRQVETMRPEIEKIVDGILDRLLALEPPVDILTHLALPMSTQVICHLLGVPYEDR 174 Query: 180 AERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQ 239 F+ P + R AL +L +D ++ + A Sbjct: 175 ---------EFFQERSELAS----------RPNDDRSMPALIELVEYLDGLVRTKTAHPD 215 Query: 240 KPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADR 299 LL + + G+ I QE+ + V +L G ET A+ + + L HPE A Sbjct: 216 TG--LLGTAVTERLLKGE-ITHQELVNNAVLLLAAGHETSANQVTLSVLTLLRHPETAAE 272 Query: 300 IRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESELGGYRIPAG 359 +R++ E + N + E +R L R A A+ LG + I AG Sbjct: 273 LREQPELMP-----------------NAVDELLRYHSIADGLRRAATADIVLGDHTIRAG 315 Query: 360 ADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQ 419 +I + D ++ FD R P F G +C + + + Sbjct: 316 DGLIILLSSANHDGNTFGAEATFDIHR---------PARHHVAFGYGPHQCLGQNLARLE 366 Query: 420 LTLITAALATKYRFEQVAGSNDAVRV 445 + + L + ++A DA+RV Sbjct: 367 MEVTLGKLFRRVPALRLAQEPDALRV 392 >4GGV-A nrPDB Length = 418 Score = 222 bits (566), Expect = 2e-58, Method: Composition-based stats. Identities = 75/407 (18%), Positives = 137/407 (33%), Gaps = 43/407 (10%) Query: 45 LAFMSQLRDHGDVVRIKLGPKTVYAVTNPELTGALALNPDYHI---AGPLWESLEGLLGK 101 ++ R VV + V+ V + + D A L S++ L + Sbjct: 35 HLWLRGQRPESPVVFDETQG--VWNVYGYPEAMDILNDHDTFTSDLAHLLPVSVDAPLLE 92 Query: 102 EGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDATSESFRV 161 ++ + P HR+ R+ + AF + + + L + ++ ++ Sbjct: 93 GDMSQMDPPRHRKYRQLVSRAFTPRLVADMETRVADITRELLDAVDGKPEIEIAADL-AY 151 Query: 162 AVRVAARCLLRGQYMDER--AERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDA 219 + V L G +R ++ + F G G R + Sbjct: 152 PLPVIVIAELLGVPAGDRDLFKKWADDIIEGFSGFSFLDTSGQGE------QDVRDATER 205 Query: 220 LADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETI 279 L L + + ERR + + +DLLT L++A+ D G+ + + EI + +L G T Sbjct: 206 LRPLLDYMAGHVTERRRTPR--EDLLTHLVQAEVD-GERLTDNEIVNVANILLVTGHITT 262 Query: 280 ASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVW 339 T+ + L PE A ++R + V G I EA+R+ Sbjct: 263 TMTLGNTVLCLDADPEVAAKVRADRSLVPG-----------------AIEEALRVLSPSA 305 Query: 340 VLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYA 399 L R E E+ G IP ++ A RDP+ + D +DP R Sbjct: 306 ALARGTSREVEVAGTVIPKDQIVMLWLGAGNRDPRQFTDPEVYDPTR---------DPNP 356 Query: 400 MKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRVG 446 F G C + + + AL ++ + + Sbjct: 357 HFGFGRGIHFCLGAPLARLEGRVALNALFDRFPVLRTDPAKPPTFFP 403 >4OQS-A nrPDB Length = 433 Score = 220 bits (560), Expect = 1e-57, Method: Composition-based stats. Identities = 74/396 (18%), Positives = 135/396 (34%), Gaps = 70/396 (17%) Query: 64 PKTVYAVTNPELTGALALNPDYHIAGPLWESLEGLLGKEGVAT----------ANGPLHR 113 + VT+ + ++P + + ++ + G AT + P H Sbjct: 44 GHIGWLVTSHAAARTVMIDPRFSNRPEHKHPVFSVIPRPGGATKAPAPGWFINMDAPEHT 103 Query: 114 RQRRTIQPAFRLDAIPAYGPIMEEEAH-ALTERWQPGKTVDATSESFRVAVRVAARCLLR 172 R RR + F + I P + + L + G VD +F + V C L Sbjct: 104 RYRRMLISQFTVRRIKELEPRIVQITEDHLDAMAKAGPPVDLVQ-AFALPVPSLVICELL 162 Query: 173 GQ-YMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALADLHLLVDEII 231 G Y D + + + AL L + E++ Sbjct: 163 GVSYADHAFFQEQTTIMASVDKTQDEVTT------------------ALGKLTRYIAELV 204 Query: 232 AERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALA 291 A +R S DDLL +L+ D + ++E+ + + +L G ET A+ + AL Sbjct: 205 ATKRLS--PKDDLLGSLITDTD-----LTDEELTNIALLLLVAGHETTANMLGLGTFALL 257 Query: 292 DHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLT--RRAVAES 349 HPE + + + E +R V + T R A+ + Sbjct: 258 QHPEQIAALDS----------------------PDAVEELLRYLSIVHLGTPNRAALEDV 295 Query: 350 ELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRK 409 EL G I G + A+ RDPK +D+ DR + A F G + Sbjct: 296 ELEGQMIRKGDTVAIGLPAVNRDPKVFDEPDILQLDRVDARKHA--------AFGGGIHQ 347 Query: 410 CPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRV 445 C + ++ + L ++ ++A + +++ Sbjct: 348 CLGQQLARVEMRIGFTRLFARFPSLRLAVPAEEIKL 383 >5XNT-A nrPDB Length = 411 Score = 219 bits (559), Expect = 1e-57, Method: Composition-based stats. Identities = 63/412 (15%), Positives = 143/412 (34%), Gaps = 53/412 (12%) Query: 48 MSQLRD--HGDVVRIKLGPKTVYAVTNPELTGALALNPDYHIAGPLWESLE--------G 97 + + D V G T + V E + + + + ++ Sbjct: 23 YAWCKRMLENDPVSYHEGTDT-WNVFKYEDVKRVLSDYKHFSSVRKRTTISVGTDSEEGS 81 Query: 98 LLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDATSE 157 + K + A+ P HR++R + AF ++ + P ++E A L E +D Sbjct: 82 VPDKIKITEADPPEHRKRRSLLAAAFTPRSLQNWEPRIQEIADELIEEMDEETEIDIVQS 141 Query: 158 SFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFN 217 + + L G +R +F+ + +P + + ++ Sbjct: 142 LAS-PLPIIVMSDLMGVPSKDRL---------LFKKWVDILFLPFDKEKQEEVNELKQV- 190 Query: 218 DALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSE 277 A + + + I+ ++R + DD+++ LL+A+ D G+ + E+ + IL G E Sbjct: 191 -AAKEYYQYLYPIVVQKRLN--PADDIISDLLKAEVD-GEMFTDDEVVRTTMLILGAGVE 246 Query: 278 TIASTIMWLLQALA-DHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRP 336 T + + +L D E + + ++ V + E +R R Sbjct: 247 TTSHLLANSFYSLLYDDKEVYQELHENLDLVP-----------------QAVEEMLRYRF 289 Query: 337 AVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVP 396 + L R +++L G + G +++ A D + ++D + R ++ Sbjct: 290 NLIKLDRTVKEDNDLLGVELKEGENVVVWMSAANLDEEMFEDAFTLNIHRPNNKK----- 344 Query: 397 KYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRVGIT 448 F G C + + + K++ + A + + +T Sbjct: 345 ---HLTFGNGPHFCLGAPLARLEAKIALTTFLKKFKHIE-AVPSFQLEDNLT 392 >6GK6-A nrPDB Length = 411 Score = 219 bits (559), Expect = 1e-57, Method: Composition-based stats. Identities = 78/412 (18%), Positives = 138/412 (33%), Gaps = 57/412 (13%) Query: 39 RLARDPLAFMSQLRDHG------------DVVRIKLGPKTVYAVTNPELTGALALNPDYH 86 +P A +++R G + V + +P L PD Sbjct: 14 SSRAEPHAIYARMRAAGRLHRLVHPRLDVPIWVAVRYDDCVELLKDPRLIRDFRKLPDEV 73 Query: 87 IAGPLWESLEGLLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERW 146 S + + A+ P H R R +Q AF + P ++E A L + Sbjct: 74 RRRYFPLSDRTTFMDQHMLDADPPDHTRLRAIVQRAFSPRMMEGLRPRIQEIADGLIDAV 133 Query: 147 QPGKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLY 206 + ++ ++ F + A L G +++R FR + ++ P Sbjct: 134 IDRRRMELIAD-FAFPLPTAVIAELLGLPVEDRGR---------FRRWTKILLAP----- 178 Query: 207 RLPLPANRRFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHD 266 R + + + RR + + DDL++ LL A++ + E+ Sbjct: 179 AKDREFVERAQPVVEEFAAYFRALADARRKAPR--DDLISGLLLAEEQEH-KLSPAELSS 235 Query: 267 QVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGN 326 V +L G ET I + L HP R+ ++ V G+ Sbjct: 236 MVFLLLVAGHETTVHLIASGMLLLLSHPAERRRLDEDPGLV-----------------GS 278 Query: 327 VIVEAMRLR-PAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPD 385 + EA+R PA R ++ + EL G R+PAG + A RDP+ + D FD Sbjct: 279 AVEEALRCEGPAELSTIRWSLEDIELFGARVPAGEGVAAGLLAANRDPQHFPDPDRFDIG 338 Query: 386 RWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVA 437 R F G C + + + + L + ++A Sbjct: 339 R---------SPNRHIGFGGGIHFCLGAMLARIEAAIAFSTLLRRLPRIELA 381 >4OQR-A nrPDB Length = 457 Score = 218 bits (556), Expect = 3e-57, Method: Composition-based stats. Identities = 74/396 (18%), Positives = 134/396 (33%), Gaps = 70/396 (17%) Query: 64 PKTVYAVTNPELTGALALNPDYHIAGPLWESLEGLLGKEGVAT----------ANGPLHR 113 + VT+ + ++P + + ++ + G AT + P H Sbjct: 83 GHIGWLVTSHAAARTVMIDPRFSNRPEHKHPVFSVIPRPGGATKAPAPGWFTNMDAPEHT 142 Query: 114 RQRRTIQPAFRLDAIPAYGPIMEEEAH-ALTERWQPGKTVDATSESFRVAVRVAARCLLR 172 R RR + F + I P + L + G VD +F + V C L Sbjct: 143 RYRRMLISQFTVRRIKELEPRIVRITEDHLDAMAKAGPPVDLVQ-AFALPVPSLVICELL 201 Query: 173 GQ-YMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALADLHLLVDEII 231 G Y D + + + AL L + E++ Sbjct: 202 GVSYADHAFFQEQTTIMVSVDKTQDEVTT------------------ALGKLTRYIAELV 243 Query: 232 AERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALA 291 A +R S DDLL +L+ D + ++E+ + + +L G ET A+ + AL Sbjct: 244 ATKRLS--PKDDLLGSLITDTD-----LTDEELTNIALILLVAGHETTANMLGLGTFALL 296 Query: 292 DHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLT--RRAVAES 349 HPE + + + E +R V + T R A+ + Sbjct: 297 QHPEQIANLDS----------------------PDAVEELLRYLSIVHLGTPNRAALEDV 334 Query: 350 ELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRK 409 EL G I G + A+ RDPK +D+ DR + A F G + Sbjct: 335 ELEGQMIRKGDTVAIGLPAVNRDPKVFDEPDILQLDRVDARKHA--------AFGGGIHQ 386 Query: 410 CPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRV 445 C + ++ + L ++ ++A + +++ Sbjct: 387 CLGQQLARVEMRIGFTRLFARFPSLRLAVPAEEIKL 422 >6FSH-A nrPDB Length = 398 Score = 218 bits (555), Expect = 4e-57, Method: Composition-based stats. Identities = 77/425 (18%), Positives = 132/425 (31%), Gaps = 67/425 (15%) Query: 36 HGWRLARDPLAFMSQLRDHGDVVRIKLGP----KTVYAVTNPELTGALALNPDYHIAGPL 91 H R DP +LR G + +I +G +T + + + + Sbjct: 10 HTRRQGFDPA---DELRAAGTLTKISIGSGADAETTWLAAGHAVVRQVLGDHQQFSTRRR 66 Query: 92 WESLEGLLGKE---------GVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEA-HA 141 W+ + + GK + + P H R R + P F + P +EE Sbjct: 67 WDPRDEIGGKGIFRPRELVGNLMDYDPPEHTRLRHLLTPGFTQRRMRRLAPRIEEIVTDR 126 Query: 142 LTERWQPGKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVP 201 L Q G D E F V A C L G D+R M + Sbjct: 127 LDAMEQAGPPADLI-ELFADEVPGAVLCELIGVPRDDRD-----------------MFMK 168 Query: 202 LGPLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGE 261 L + + +R + +IA R D + +++ ++GD I + Sbjct: 169 LCHGHLDASLSQKRRAALGDKFSRYLLAMIARERK--DPGDGFIGSIVA---EHGDTITD 223 Query: 262 QEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKL 321 +E+ V ++ G + ++ I + AL HPE +R + ++ Sbjct: 224 EELRGVCVQLMLAGDDNVSGMIGLGVLALLRHPEQIAALRGDDQS--------------- 268 Query: 322 RHTGNVIVEAMRLRP-AVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNL 380 + E +R R AV + + I G ++ S RD D Sbjct: 269 --ADRAVDELIRYLTVPYAPTPRTAVEDVMVADQVIKEGETVLCSLPMANRDRALLPDAD 326 Query: 381 EFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSN 440 D R F G C + QL + AL ++ Q+A Sbjct: 327 RLDVTR---------TPVPHVAFGHGIHHCLGAALTRLQLRIAYTALWRRFPALQLADPA 377 Query: 441 DAVRV 445 + Sbjct: 378 QEIMF 382 >4YT3-A nrPDB Length = 410 Score = 217 bits (552), Expect = 9e-57, Method: Composition-based stats. Identities = 64/414 (15%), Positives = 145/414 (35%), Gaps = 57/414 (13%) Query: 48 MSQLRD--HGDVVRIKLGPKTVYAVTNPELTGALALNPDYHIAGPLWESLEGLLGKEG-- 103 + + D V G T + V E + DY + + +G + Sbjct: 23 YAWCKRMLENDPVSYHEGTDT-WNVFKYEDVKRVL--SDYKHFSSVRKRTTISVGTDSEE 79 Query: 104 --------VATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDAT 155 + ++ P HR++R + AF ++ + P ++E A L + G +D Sbjct: 80 GSVPEKIQITESDPPDHRKRRSLLAAAFTPRSLQNWEPRIQEIADELIGQMDGGTEIDIV 139 Query: 156 SESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRR 215 + + + L G +R +F+ + +P + + ++ Sbjct: 140 ASLAS-PLPIIVMADLMGVPSKDRL---------LFKKWVDTLFLPFDREKQEEVDKLKQ 189 Query: 216 FNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPG 275 A + + + I+ ++R + DD+++ LL+++ D G+ + E+ + IL G Sbjct: 190 V--AAKEYYQYLYPIVVQKRLN--PADDIISDLLKSEVD-GEMFTDDEVVRTTMLILGAG 244 Query: 276 SETIASTIMWLLQALA-DHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRL 334 ET + + +L D E + + ++ V + E +R Sbjct: 245 VETTSHLLANSFYSLLYDDKEVYQELHENLDLVP-----------------QAVEEMLRF 287 Query: 335 RPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAAN 394 R + L R +++L G + G ++ A D + ++D + R ++ Sbjct: 288 RFNLIKLDRTVKEDNDLLGVELKEGDSVVVWMSAANMDEEMFEDPFTLNIHRPNNKK--- 344 Query: 395 VPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRVGIT 448 F G C + + + A K++ + A + + +T Sbjct: 345 -----HLTFGNGPHFCLGAPLARLEAKIALTAFLKKFKHIE-AVPSFQLEENLT 392 >3S79-A nrPDB Length = 503 Score = 215 bits (548), Expect = 3e-56, Method: Composition-based stats. Identities = 83/419 (19%), Positives = 171/419 (40%), Gaps = 28/419 (6%) Query: 52 RDHGDVVRIKLGPKTVYAVT-NPELTGALALNPDYHIAGPLWESLEGLLGKEGVATANGP 110 R +G+ +R+ + + ++ + + + N G + ++G+ N P Sbjct: 79 RVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNP 138 Query: 111 L-HRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQP----GKTVDATSESFRVAVRV 165 + R A + + E +R + VD + RV + Sbjct: 139 ELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDT 198 Query: 166 AARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALADLHL 225 + L +DE A + V + F ++ P L +++ ++ DL Sbjct: 199 -SNTLFLRIPLDESA--IVVKIQGYFDAWQALLIKPDIFFKISWL--YKKYEKSVKDLKD 253 Query: 226 LVDEIIAERRASGQKPD------DLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETI 279 ++ +IAE+R + D T L+ A+ + + ++ ++ +L +T+ Sbjct: 254 AIEVLIAEKRRRISTEEKLEECMDFATELILAEKRG--DLTRENVNQCILEMLIAAPDTM 311 Query: 280 ASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVW 339 + ++ ++L +A HP + I E++ V G R + +D++KL+ N I E+MR +P V Sbjct: 312 SVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVD 371 Query: 340 VLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYA 399 ++ R+A+ + + GY + G +II + + R + EF + + A NVP Sbjct: 372 LVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLE-FFPKPNEFTLENF----AKNVPYRY 426 Query: 400 MKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRVGITLRPHDLLVRP 458 +PF G R C + +M + I L ++ + + G V + HDL + P Sbjct: 427 FQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQC----VESIQKIHDLSLHP 481 >2WM5-A nrPDB Length = 435 Score = 215 bits (547), Expect = 4e-56, Method: Composition-based stats. Identities = 86/452 (19%), Positives = 146/452 (32%), Gaps = 61/452 (13%) Query: 24 PPVAGGGVPLLGH--GWRLARD-PLAFMSQLRDHGDVV---RIKLGP----KTVYAVTNP 73 PP LG W L D + LR + I+L +A+T Sbjct: 23 PPEVPIADIELGSLDFWALDDDVRDGAFATLRREAPISFWPTIELPGFVAGNGHWALTKY 82 Query: 74 ELTGALALNPDYHIAGPLWES------LEGLLGKEGVATANGPLHRRQRRTIQPAFRLDA 127 + + +PD + P L G + + P H+R R + AF Sbjct: 83 DDVFYASRHPDIFSSYPNITINDQTPELAEYFG--SMIVLDDPRHQRLRSIVSRAFTPKV 140 Query: 128 IPAYGPIMEEEAHALTERW---QPGKTVDATSESFRVAVRVAARCLLRGQYMDERAERLC 184 + + + AH L P + D SE + + C + G + Sbjct: 141 VARIEAAVRDRAHRLVSSMIANNPDRQADLVSEL-AGPLPLQIICDMMGIPKADHQR--- 196 Query: 185 VALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQKPDDL 244 ++ V LG F AD+ + +RR + DDL Sbjct: 197 ---------IFHWTNVILGFGDPDLATDFDEFMQVSADIGAYATALAEDRRVNHH--DDL 245 Query: 245 LTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEV 304 ++L+EA+ D G+ + +EI + ++ G+ET + I + AL+ +PE DR + Sbjct: 246 TSSLVEAEVD-GERLSSREIASFFILLVVAGNETTRNAITHGVLALSRYPEQRDRWWSDF 304 Query: 305 EAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESELGGYRIPAGADIIY 364 + G P A E E +R V + R + EL G ++ AG + Sbjct: 305 D---GLAPTAVE-------------EIVRWASPVVYMRRTLTQDIELRGTKMAAGDKVSL 348 Query: 365 SPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLIT 424 + RD + D FD R P + G C + + ++ + Sbjct: 349 WYCSANRDESKFADPWTFDLAR--------NPNPHLGFGGGGAHFCLGANLARREIRVAF 400 Query: 425 AALATKYRFEQVAGSNDAVRVGITLRPHDLLV 456 L + + L V Sbjct: 401 DELRRQMPDVVATEEPARLLSQFIHGIKTLPV 432 >1LG9-A nrPDB Length = 398 Score = 214 bits (545), Expect = 6e-56, Method: Composition-based stats. Identities = 72/427 (16%), Positives = 134/427 (31%), Gaps = 65/427 (15%) Query: 36 HGWRLARDPLAFMSQLRDHGDVVRIKLGP----KTVYAVTNPELTGALALNPDYHIAGPL 91 H R DP +L G + R+ +G +T + T + + + Sbjct: 10 HIRRQGLDPA---DELLAAGALTRVTIGSGADAETHWMATAHAVVRQVMGDHQQFSTRRR 66 Query: 92 WESLEGLLGKE---------GVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHAL 142 W+ + + GK + + P H R RR + P F L + P +E+ + Sbjct: 67 WDPRDEIGGKGIFRPRELVGNLMDYDPPEHTRLRRKLTPGFTLRKMQRMAPYIEQIVNDR 126 Query: 143 TERWQPGKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPL 202 + + + V A C L G D+R + + + + + Sbjct: 127 LDEMERAGSPADLIAFVADKVPGAVLCELVGVPRDDRDMFMKLCHGHLDASLSQ------ 180 Query: 203 GPLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQ 262 +R + +IA R + + ++ A++ + GD ++ Sbjct: 181 -----------KRRAALGDKFSRYLLAMIARERK--EPGEGMIGAVVA---EYGDDATDE 224 Query: 263 EIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLR 322 E+ V ++ G + I+ I + A+ HPE D R + ++ Sbjct: 225 ELRGFCVQVMLAGDDNISGMIGLGVLAMLRHPEQIDAFRGDEQS---------------- 268 Query: 323 HTGNVIVEAMRLRP-AVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLE 381 + E +R R A + L G I G +I S A RDP D Sbjct: 269 -AQRAVDELIRYLTVPYSPTPRIAREDLTLAGQEIKKGDSVICSLPAANRDPALAPDVDR 327 Query: 382 FDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSND 441 D R F G C + +L + L ++ ++A Sbjct: 328 LDVTR---------EPIPHVAFGHGVHHCLGAALARLELRTVFTELWRRFPALRLADPAQ 378 Query: 442 AVRVGIT 448 +T Sbjct: 379 DTEFRLT 385 >4TX3-A nrPDB Length = 404 Score = 214 bits (545), Expect = 6e-56, Method: Composition-based stats. Identities = 71/424 (16%), Positives = 132/424 (31%), Gaps = 65/424 (15%) Query: 36 HGWRLARDPLAFMSQLRDHGDVVRIKLGP----KTVYAVTNPELTGALALNPDYHIAGPL 91 H R DP +LR G + +I +G +T + + + + Sbjct: 16 HTRRQGFDPA---DELRAAGTLTKISIGSGADAETTWLAAGHAVVRQVLGDHKRFSTRRR 72 Query: 92 WESLEGLLGKEG---------VATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHAL 142 ++ + + G + + P H R R + P F + P +EE Sbjct: 73 FDRRDEIGGTGVFRPRELVGNLMDYDPPEHTRLRHLLTPGFTQRRMRRLAPRIEEIVTDR 132 Query: 143 TERWQPGKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPL 202 + + E F V A C L G D++A +F + R + Sbjct: 133 LDAMEQAGPPADLIELFADEVPGAVLCELIGVPRDDQA---------MFLQLCHRHL--- 180 Query: 203 GPLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQ 262 + R+ A + ++A R D + +++ ++GD I ++ Sbjct: 181 -----DASLSARKRAAAGEAFARYLVAMMARERK--DPGDGFIGSIVA---EHGDTITDE 230 Query: 263 EIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLR 322 E+ V ++ G + ++ I + AL HPE +R + ++ Sbjct: 231 ELRGVCVQLMLAGDDNVSGMIGLGVLALLRHPEQIAALRGDDQS---------------- 274 Query: 323 HTGNVIVEAMRLRP-AVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLE 381 + E +R R AV + + I G ++ S RD D Sbjct: 275 -ADRAVDELIRYLTVPYAPTPRTAVEDVMVADQVIKEGETVLCSLPMANRDRALLPDADR 333 Query: 382 FDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSND 441 D R F G C + QL + AL ++ Q+A Sbjct: 334 LDVTR---------TPVPHVAFGHGIHHCLGAALTRLQLRIAYTALWRRFPALQLADPAQ 384 Query: 442 AVRV 445 + Sbjct: 385 EIMF 388 >6HQG-A nrPDB Length = 425 Score = 214 bits (544), Expect = 8e-56, Method: Composition-based stats. Identities = 69/417 (16%), Positives = 142/417 (34%), Gaps = 40/417 (9%) Query: 45 LAFMSQLRDHGDVVRIKLGPKTV---YAVTNPELTGALALNPDYHIAGPLWESLEGL--L 99 + +LR V + V ++VT A+ N + + P + Sbjct: 38 WPYFERLRKEDPVHWGVSPHEDVGGYWSVTKYNDIMAVDTNHEVFSSEPTIVLPDPADDF 97 Query: 100 GKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDATSESF 159 + P H QR+T+QP + + PI+ E A + + G+ ++ + Sbjct: 98 TLPMFIAMDPPKHDVQRKTVQPIVAPNHLAYLEPIIRERAGKILDDLPIGEEINWVDKV- 156 Query: 160 RVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDA 219 + + L ++R + T + + P Sbjct: 157 SIELTTMTLATLFDFPWEDRRK------LTFWSDVATSAPESGILGTTDPEEHENLRRQT 210 Query: 220 LADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETI 279 L + + ER + KP DL++ L A ++ + E ++ ++ G++T Sbjct: 211 LFECVDYFMRLWNERVNAPPKP-DLISML--AHGESTKNMDRMEYLGNLILLIVGGNDTT 267 Query: 280 ASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVW 339 +TI + AL +P+ ++R+ + ++ E +R + + Sbjct: 268 RNTISGSVLALHQNPDQDRKLRENPGLIP-----------------AMVSETIRWQTPLA 310 Query: 340 VLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYA 399 + RRA + ELGG I G + + RD + D ++ +R + Sbjct: 311 YMRRRAKRDFELGGKTIREGDKVAMWYVSGNRDEEVIDRPNDYWIERPRVRQ-------- 362 Query: 400 MKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRVGITLRPHDLLV 456 F G +C + + QL +I + ++ +V G V +L V Sbjct: 363 HLSFGFGVHRCVGNRLAELQLKIIWEEILARFPRLEVVGPPRRVYSSFVKGYEELPV 419 >1EHE-A nrPDB Length = 403 Score = 214 bits (544), Expect = 9e-56, Method: Composition-based stats. Identities = 80/432 (18%), Positives = 151/432 (34%), Gaps = 58/432 (13%) Query: 41 ARDPLAFMSQLRDHGDVVRIKLG-PKTVYAVTNPELTGALALNPDYHIAG-----PLWES 94 +P A ++LR V ++KL + VT + +A + P + Sbjct: 15 GPEPPAEFAKLRATNPVSQVKLFDGSLAWLVTKHKDVCFVATSEKLSKVRTRQGFPELSA 74 Query: 95 L--EGLLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGK-- 150 + K + P H QR ++P F +A+ P ++ L E+ + Sbjct: 75 SGKQAAKAKPTFVDMDPPEHMHQRSMVEPTFTPEAVKNLQPYIQRTVDDLLEQMKQKGCA 134 Query: 151 --TVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRL 208 VD E F + V L G ++ E L A G Sbjct: 135 NGPVDLVKE-FALPVPSYIIYTLLGVPFNDL-EYLTQQNAIRTNGSSTA----------- 181 Query: 209 PLPANRRFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQV 268 R + A +L + ++ +R + DD+++ L + G+ I + + Sbjct: 182 -----REASAANQELLDYLAILVEQR--LVEPKDDIISKLCTEQVKPGN-IDKSDAVQIA 233 Query: 269 VAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVI 328 +L G+ T+ + I + LA HP+ +++ + Sbjct: 234 FLLLVAGNATMVNMIALGVATLAQHPDQLAQLKANPSLAP-----------------QFV 276 Query: 329 VEAMRLRPA-VWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRW 387 E R A + R A + +G + A II S + RD + +++ EF+ +R Sbjct: 277 EELCRYHTASALAIKRTAKEDVMIGDKLVRANEGIIASNQSANRDEEVFENPDEFNMNRK 336 Query: 388 LPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRVGI 447 P + F G +C ++H + A+LT + + L K+ +VA + Sbjct: 337 WPPQDP-------LGFGFGDHRCIAEHLAKAELTTVFSTLYQKFPDLKVAVPLGKINYTP 389 Query: 448 TLRPHDLLVRPV 459 R ++ PV Sbjct: 390 LNRDVGIVDLPV 401 >3RWL-A nrPDB Length = 426 Score = 213 bits (541), Expect = 2e-55, Method: Composition-based stats. Identities = 75/434 (17%), Positives = 148/434 (34%), Gaps = 41/434 (9%) Query: 25 PVAGGGVPLLGHGWRLARDPLAFMSQLRDHGDVVRIKLGPKTVYAVTNPELTGALALNPD 84 P + + RL +D G I ++ TN ++ + A Sbjct: 32 PELFYNDSVGEYFKRLRKDDPVHYCADSAFGPYWSITKYNDIMHVDTNHDIFSSDAGYGG 91 Query: 85 YHIAGPLWESLEGLLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTE 144 I + + +G L + P H QR+ + P + A + E + Sbjct: 92 IIIDDGIQKGGDGGLDLPNFIAMDRPRHDEQRKAVSPIVAPANLAALEGTIRERVSKTLD 151 Query: 145 RWQPGKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGP 204 G+ D + + + L +ER + + R P G Sbjct: 152 GLPVGEEFDWV-DRVSIEITTQMLATLFDFPFEERRK--------LTRWSDVTTAAPGGG 202 Query: 205 LYRLPLPANRRFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEI 264 + + A +L +E R + +DL++ L A + +E Sbjct: 203 VVESWDQRKTELLECAAYFQVLWNE-----RVNKDPGNDLISML--AHSPATRNMTPEEY 255 Query: 265 HDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHT 324 V+ ++ G++T +++ + AL +P+ +++ V Sbjct: 256 LGNVLLLIVGGNDTTRNSMTGGVLALHKNPDQFAKLKANPALV----------------- 298 Query: 325 GNVIVEAMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDP 384 ++ E +R + + + R A+A+SELGG I G ++ Y+ RD + D EF Sbjct: 299 ETMVPEIIRWQTPLAHMRRTAIADSELGGKTIRKGDKVVMWYYSGNRDDEVIDRPEEFII 358 Query: 385 DRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVR 444 DR P + F G +C + + QL ++ + T++ +V + VR Sbjct: 359 DRPRPRQ--------HLSFGFGIHRCVGNRLAEMQLRILWEEILTRFSRIEVMAEPERVR 410 Query: 445 VGITLRPHDLLVRP 458 ++VR Sbjct: 411 SNFVRGYAKMMVRV 424 >4TRI-A nrPDB Length = 407 Score = 213 bits (541), Expect = 2e-55, Method: Composition-based stats. Identities = 71/411 (17%), Positives = 135/411 (32%), Gaps = 48/411 (11%) Query: 48 MSQLRDHGDVVRIKLGPKTVYAVTNPELTGALALNPDYHIAGPLWESLEGLLGKEGVATA 107 +R + V R + G + A T + NP+ + + G + Sbjct: 27 YRWMRANEPVFRDRNG---LAAATTYQAVLDAERNPELFSSTGGIRPDQP--GMPYMIDM 81 Query: 108 NGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDATSESFRVAVRVAA 167 + P H +R+ + F + + L + D + + +A Sbjct: 82 DDPQHLLRRKLVNAGFTRKRVMDKVDSIGRLCDTLIDAVCERGECDFVRDI-AAPLPMAV 140 Query: 168 RCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALADLHLLV 227 + G ER + +V L + A ++ D A Sbjct: 141 IGDMLGVLPTERD---------MLLKWSDDLVCGLSS--HVDEAAIQKLMDTFAAYTEFT 189 Query: 228 DEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLL 287 ++I +RRA + DDL + L+ ++ + G + + EI + + IL G ET T+ Sbjct: 190 KDVITKRRA--EPTDDLFSVLVNSEVE-GQRMSDDEIVFETLLILIGGDETTRHTLSGGT 246 Query: 288 QALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVA 347 + L H + D + +V+ + G I E +R V + R A Sbjct: 247 EQLLRHRDQWDALVADVDLLPG-----------------AIEEMLRWTSPVKNMCRTLTA 289 Query: 348 ESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGK 407 ++ G + AG I+ + D + D F DR + F G Sbjct: 290 DTVFHGTELRAGEKIMLMFESANFDESVFGDPDNFRIDR---------NPNSHVAFGFGT 340 Query: 408 RKCPSDHFSMAQLTLITAALATKYRFEQVAGS-NDAVR-VGITLRPHDLLV 456 C + + +L L+T + + ++A +R P + V Sbjct: 341 HFCLGNQLARLELRLMTERVLRRLPDLRLADDAPVPLRPANFVSGPESMPV 391 >5YSW-A nrPDB Length = 441 Score = 212 bits (539), Expect = 3e-55, Method: Composition-based stats. Identities = 77/448 (17%), Positives = 141/448 (31%), Gaps = 76/448 (16%) Query: 15 APGAPELREP-PVAGGGVPLLGHGWRLARDPLAF---MSQLRDHGDVVRIKLG-PKTVYA 69 AP LR P P DP + + + G V R L + Sbjct: 30 APSTESLRSPLPPEFVR----------REDPFHVPPALVAVSERGPVARATLAAGDPFWL 79 Query: 70 VTNPELTGALALNPDYHIAGPLWES----LEGLLGK---------EGVATANGPLHRRQR 116 V+ E A+ +P + + L + + P H R R Sbjct: 80 VSGYEEARAVLSDPRFSSDRFQYHPWFKELSPEFRERLRDDKARAGSFINMDPPEHTRYR 139 Query: 117 RTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDATSESFRVAVRVAARCLLRGQYM 176 + + F + I G ++E + G T F C L G Sbjct: 140 KLLTGQFTVRRIRELGARIDEIVAGRVDAMLAGGTTADLMTEFAFPAPSLMICELLGVRY 199 Query: 177 DERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALADLHLLVDEIIAERRA 236 ++RAE F+ ++ P+ L + ++ ++RA Sbjct: 200 EDRAE---------FQQRASALLQMNAPV--------AEAVKNADALRAFMQALVTDKRA 242 Query: 237 SGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEH 296 + D+++ L+ + + + E+ + +L G +T AS + + L P Sbjct: 243 N--PAGDIISGLIHHAGADP-ALTDDELINIANLLLIAGYDTTASMLGLGIFVLLQRPAQ 299 Query: 297 ADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAV-WVLTRRAVAESELGGYR 355 +RD+ + + + E +R V + R A + E G Sbjct: 300 LATLRDDPSRI-----------------ADAVEELLRYLSVVNPGIFRFAKEDLEFAGEH 342 Query: 356 IPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHF 415 IPAG+ ++ S A RD + + D D R P+ F G +C Sbjct: 343 IPAGSTVVVSVVATNRDARHWPDPD-LDLTR---------PRGPHLAFGHGVHQCLGQQL 392 Query: 416 SMAQLTLITAALATKYRFEQVAGSNDAV 443 + ++ A L + ++A + V Sbjct: 393 ARMEMQAGYAELLRRLPNVRLAVPPEEV 420 >6CVC-A nrPDB Length = 433 Score = 211 bits (537), Expect = 6e-55, Method: Composition-based stats. Identities = 77/463 (16%), Positives = 142/463 (30%), Gaps = 65/463 (14%) Query: 13 PAAPGAPELREPPVAGGGVPLLGHGWRLARD---PLAFMSQLRDHGDV-VRIKL------ 62 P G P PP LG RD + LR + + Sbjct: 13 PRVNGTP----PPEVPLADIELGSLEFWGRDDDFRDGAFATLRREAPISFWPPIELAGLT 68 Query: 63 GPKTVYAVTNPELTGALALNPDYHIAGPLW------ESLEGLLGKEGVATANGPLHRRQR 116 K +A+T + + +P+ + P L G + + P H+R R Sbjct: 69 AGKGHWALTKHDDIHFASRHPEIFHSSPNIVIHDQTPELAEYFG--SMIVLDDPRHQRLR 126 Query: 117 RTIQPAFRLDAIPAYGPIMEEEAHALTERW---QPGKTVDATSESFRVAVRVAARCLLRG 173 + AF + + E AH L P D SE + + C + G Sbjct: 127 SIVSRAFTPKVVARIEASVRERAHRLVAAMIENHPDGQADLVSEL-AGPLPLQIICDMMG 185 Query: 174 QYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALADLHLLVDEIIAE 233 ++ ++ V LG F + + + Sbjct: 186 IPEEDH------------EQIFHWTNVILGFGDPDLTTDFDEFLQVSMAIGGYATALADD 233 Query: 234 RRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADH 293 RR + DL T+L+EA+ D G+ + EI + ++ G+ET + I + AL+ + Sbjct: 234 RRVNHH--GDLTTSLVEAEVD-GERLSSSEIAMFFILLVVAGNETTRNAISHGMLALSRY 290 Query: 294 PEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESELGG 353 P+ + + + + + E +R V + R + +L G Sbjct: 291 PDERAKWWSDFDGL----------------AATAVEEIVRWASPVVYMRRTLSQDVDLRG 334 Query: 354 YRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSD 413 ++ AG + + RD + + D FD R P + G C Sbjct: 335 TKMAAGDKVTLWYCSANRDEEKFADPWTFDVTR--------NPNPQVGFGGGGAHFCLGA 386 Query: 414 HFSMAQLTLITAALATKYRFEQVAGSNDAVRVGITLRPHDLLV 456 + + ++ ++ L + + L V Sbjct: 387 NLARREIRVVFDELRRQMPDVVATEEPARLLSQFIHGIKRLPV 429 >6B11-A nrPDB Length = 440 Score = 211 bits (536), Expect = 6e-55, Method: Composition-based stats. Identities = 72/410 (17%), Positives = 132/410 (32%), Gaps = 54/410 (13%) Query: 43 DPLAFMSQLRDHGDVVRIKL-GPKTVYAVTNPELTGALALNPDYHIAGPLWESLEGLLGK 101 P + LR + R +L V+ ++ + AL +P I L G+ Sbjct: 64 SPPEQYAALRAEEPIARAELWDGAPVWLISRQDHVRALLADPRVSIHPAKLPRLSPSDGE 123 Query: 102 ----EGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQP-GKTVDATS 156 + T + P H R P F L + P +E+ L + G D + Sbjct: 124 AEASRSLLTLDPPDHGALRGHFIPEFGLRRVRELRPSVEQIVTGLLDDLTARGDEADLLA 183 Query: 157 ESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRF 216 + F + + C L ++R F+ + P L R Sbjct: 184 D-FALPMATQVICRLLDIPYEDRD---------YFQERTEQATRPAAGEEALEALLELR- 232 Query: 217 NDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGS 276 +D +I+ + + D +L +++ G + ++ D V +L G Sbjct: 233 --------DYLDRLISGK-TGRESGDGMLGSMVAQARGGG--LSHADVLDNAVLLLAAGH 281 Query: 277 ETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRP 336 ET AS + + L HP + + G + E +R Sbjct: 282 ETTASMVTMSVLVLLQHPTAWRELTVNPGLLPG-----------------AVDELLRYLS 324 Query: 337 AVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVP 396 L R A A+ E+ G+ I AG +++ A RD + + FD R Sbjct: 325 IADGLRRSATADIEIDGHTIRAGDGLVFLLAAANRDEAVFSEPEAFDIHR---------S 375 Query: 397 KYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRVG 446 F G +C + + +L + A+ + + +R+ Sbjct: 376 ARRHVAFGYGPHQCLGQNLARMELEVALGAVLERLPALRPTTDVAGLRLK 425 >3TKT-A nrPDB Length = 450 Score = 211 bits (536), Expect = 8e-55, Method: Composition-based stats. Identities = 71/427 (16%), Positives = 145/427 (33%), Gaps = 48/427 (11%) Query: 48 MSQLRDHGDVVRIKLGPK---TVYAVTNPELTGALALNPDYHIAGPLWESLEGLLGK--- 101 LR V ++ + V++ + + + + P +G+ Sbjct: 51 FDALRAEAPVAKVVAPDDEHEPFWLVSSFDGVMKASKDNATFLNNPKSTVFTLRVGEMMA 110 Query: 102 -----------EGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGK 150 E + + P H + RR Q F + + + A+ +R Sbjct: 111 KAITGGSPHLVESLVQMDAPKHPKLRRLTQDWFMPKNLARLDGEIRKIANEAIDRMLGAG 170 Query: 151 TVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPL 210 + + G ++ + L + +F G M G P Sbjct: 171 EEGDFMALVAAPYPLHVVMQILGVPPEDEPKMLFLT-QQMFGGQDEDMNKS-GLKDLPPE 228 Query: 211 PANRRFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVA 270 ++ A+A+ + AERR + P D + ++ +G+P+ +++ + Sbjct: 229 QISQIVAGAVAEFERYFAGLAAERRRN---PTDDVATVIANAVVDGEPMSDRDTAGYYII 285 Query: 271 ILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVE 330 + G +T +++ ALA P+ R++ + + G ++ E Sbjct: 286 TASAGHDTTSASSAGAALALARDPDLFARVKADRNLLPG-----------------IVEE 328 Query: 331 AMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPE 390 A+R V R A ++EL G +I AG ++ + A DP + + +FDP R Sbjct: 329 AIRWTTPVQHFMRTAATDTELCGQKIAAGDWLMLNYVAANHDPAQFPEPRKFDPTR---- 384 Query: 391 RAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRVGITLR 450 P F AG +C H + ++ ++ L + ++AG V Sbjct: 385 -----PANRHLAFGAGSHQCLGLHLARLEMRVLLDVLLDRVDSLELAGEPKRVNSTFVGG 439 Query: 451 PHDLLVR 457 L +R Sbjct: 440 FKSLPMR 446 >5XW2-A nrPDB Length = 419 Score = 209 bits (532), Expect = 2e-54, Method: Composition-based stats. Identities = 72/439 (16%), Positives = 128/439 (29%), Gaps = 60/439 (13%) Query: 16 PGAPELREPPVAGGGVPLLGHGWRLARDPLAFMSQLRDHGDVVRIKLGPKTVYAVTNPEL 75 P + P G P H W R P + + V Sbjct: 16 PRGSHMTTPAERWGIHP--EHFWLYGRRPRQMVEFDEK-----------MNAWNVYGYAE 62 Query: 76 TGALALNPDYHIA---GPLWESLEGLLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYG 132 + +P + L + + + + P HR R+ + AF + Sbjct: 63 AIEVLGDPGTFSSHMSRLLPMGADEAFTEGDLLQTDPPDHRELRKLVSHAFTPKVVAELE 122 Query: 133 PIMEEEAHALTERWQPGKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFR 192 P + L + T D + + V L +R +F Sbjct: 123 PRITALTQELLDAVADRDTFDLM-TALAYPLPVTVVAELLSIPSADRH---------LFE 172 Query: 193 GMYRRMVVPLGPLYRLPLPANRRF-----NDALADLHLLVDEIIAERRASGQKPDDLLTA 247 G +V LG + P ++ + + + E AE R + DL+ Sbjct: 173 GWMTEIVHSLGDVSMEDAPEDQERIFEAGMAPMRKMLEYLREHAAECRR--RPRGDLMGK 230 Query: 248 LLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAV 307 L+EA+ D G + + I + +L G T I + L +PE A R+R + + Sbjct: 231 LIEAEVD-GRRLTDNHIVNFAKMLLIAGYLTTTMLIGNTVLCLDSYPEQAARVRADRSLI 289 Query: 308 TGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPY 367 G ++ E+MR V R + E+ G R+ A ++ Sbjct: 290 PG-----------------LLEESMRFLSPVAATYRATTRDVEVAGQRLSADQMVMVWFG 332 Query: 368 AIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAAL 427 A RD + + + FD R F G C + + + L Sbjct: 333 AANRDARQFAEPELFDMTR---------GPNPHLGFGRGIHFCLGGPLARMEGRVALDHL 383 Query: 428 ATKYRFEQVAGSNDAVRVG 446 ++ + Sbjct: 384 LDRFPELYTDPERPPTFMP 402 >5Y1I-A nrPDB Length = 403 Score = 209 bits (531), Expect = 2e-54, Method: Composition-based stats. Identities = 81/405 (20%), Positives = 136/405 (33%), Gaps = 51/405 (12%) Query: 64 PKTVYAVTNPELTGALALNPDYHIAG-----PLWESLEGL--LGKEGVATANGPLHRRQR 116 T + VT AL +P G P + + + A + P H R R Sbjct: 41 GSTPWVVTRHADQRALLSDPRVSHDGLRDGYPHISADFKFLSMAQPSFAGQDDPEHGRIR 100 Query: 117 RTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDATSESFRVAVRVAARCLLRGQYM 176 R + F I A P +++ L + G E+ + V V C + G Sbjct: 101 RMVTLPFTARRIEAMRPAIQKITDELIDGMLAGPKPVDLVEALALPVPVRVICEMLGVPY 160 Query: 177 DERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALADLHLLVDEIIAERRA 236 ++R A ++R + A + + E++ + Sbjct: 161 EDREFLQQNNNAMIYRDTAQGDA-----------------QKAAIAQAMYLKELVGTK-- 201 Query: 237 SGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEH 296 G + DD+L+ L A I + + + +L G ET A+ I AL ++PE Sbjct: 202 LGDRGDDILSDL--AVQVEAGEITQDDAAGIGMMLLGAGHETTANMIALGTLALLENPEQ 259 Query: 297 ADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVW-VLTRRAVAESELGGYR 355 +R D + N + E +R + R A + E+GG Sbjct: 260 LAEVR---------------DSDDPKVIVNTVEELLRYLTIAQDTVRRIAAEDIEIGGVV 304 Query: 356 IPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHF 415 I AG I++ A DP Y + PDR RA F G +C Sbjct: 305 IKAGEGIVFPLNAANWDPDLYPEA----PDRLDIHRA---NARRHLAFGYGVHQCLGATL 357 Query: 416 SMAQLTLITAALATKYRFEQVAGSNDAVRVGITLRPHDLLVRPVA 460 + +L ++ + L + +AG+ D + H + PV Sbjct: 358 ARVELQIVYSTLLRRIPTLALAGTLDEIPFKHDQIAHGVYELPVT 402 >3TYW-A nrPDB Length = 417 Score = 205 bits (521), Expect = 4e-53, Method: Composition-based stats. Identities = 85/409 (20%), Positives = 144/409 (35%), Gaps = 57/409 (13%) Query: 48 MSQLRDHGDVVRIKLG-PKTVYAVTNPELTGALALNPDYH--IAGPLWESLEGLLGKEGV 104 + LR V R+ L + + VT + L +P I P + +L + G Sbjct: 35 YAALRTDDPVARVTLPTRREAWVVTRYDDVRELLSDPRVSADIRRPGFPALGEGEQEAGA 94 Query: 105 AT-----ANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTE-RWQPGKTVDATSES 158 + P H R RR + PAF + + A P ++ + + G VD S + Sbjct: 95 RFRPFIRTDAPEHTRYRRMLLPAFTVRRVRAMRPAVQARVDEILDGMLAAGGPVDLVS-A 153 Query: 159 FRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFND 218 + AV + C L G + FR + R + ++ Sbjct: 154 YANAVSTSVICELLGIPRHDL---------EFFRDVTRISGS--------RNSTAEQVSE 196 Query: 219 ALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSET 278 AL L L+ ++AERR + DDL++ L+ G+ + +++ + + G ET Sbjct: 197 ALGGLFGLLGGLVAERRE--EPRDDLISKLVTDHLVPGN-VTTEQLLSTLGITINAGRET 253 Query: 279 IASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAV 338 S I L D PE +R + + + + E +R+ Sbjct: 254 TTSMIALSTLLLLDRPELPAELRKDPDLMP-----------------AAVDELLRVLSVA 296 Query: 339 WVLT-RRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPK 397 + R A + EL G +PA +I DP+ +DD D R Sbjct: 297 DSIPLRVAAEDIELSGRTVPADDGVIALLAGANHDPEQFDDPERVDFHRTDN-------- 348 Query: 398 YAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRVG 446 F G +C H + +L + L + ++AG D V V Sbjct: 349 -HHVAFGYGVHQCVGQHLARLELEVALETLLRRVPTLRLAGERDQVVVK 396 >3IVY-A nrPDB Length = 433 Score = 204 bits (518), Expect = 9e-53, Method: Composition-based stats. Identities = 78/455 (17%), Positives = 144/455 (31%), Gaps = 64/455 (14%) Query: 25 PVAGGGVPLLGHGWRLARDPLAFMSQLRDHGDVVR--------IKLGPKTVYAVTNPELT 76 P G R P+A ++LR + +A+T Sbjct: 20 PNLPPGFDFTDPAIYAERLPVAEFAELRSAAPIWWNGQDPGKGGGFHDGGFWAITKLNDV 79 Query: 77 GALALNPDYHIA---------GPLWESLEGLLGKEGVATANGPLHRRQRRTIQPAFRLDA 127 ++ + D + + + + + + P H R R+ I F A Sbjct: 80 KEISRHSDVFSSYENGVIPRFKNDIAREDIEVQRFVMLNMDAPHHTRLRKIISRGFTPRA 139 Query: 128 IPAYGPIMEEEAHALTERWQPGKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCVAL 187 + ++E A + + D + + + A L G ++R + Sbjct: 140 VGRLHDELQERAQKIAAEAAAAGSGDFVEQVSC-ELPLQAIAGLLGVPQEDRGKLFH--- 195 Query: 188 ATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQKPDDLLTA 247 M P Y P + A+L ++ E+ + DD++T Sbjct: 196 ------WSNEMTGNEDPEYAHIDP-----KASSAELIGYAMKMAEEK--AKNPADDIVTQ 242 Query: 248 LLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAV 307 L++A D +G+ + + E VV + G+ET ++I + A A+HP+ E Sbjct: 243 LIQA-DIDGEKLSDDEFGFFVVMLAVAGNETTRNSITQGMMAFAEHPDQW-------ELY 294 Query: 308 TGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPY 367 RP D E +R V R A+ + EL G +I G ++ Sbjct: 295 KKVRPETAAD------------EIVRWATPVTAFQRTALRDYELSGVQIKKGQRVVMFYR 342 Query: 368 AIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSA-GKRKCPSDHFSMAQLTLITAA 426 + D + + D F+ R F G C + + + LI A Sbjct: 343 SANFDEEVFQDPFTFNILR---------NPNPHVGFGGTGAHYCIGANLARMTINLIFNA 393 Query: 427 LATKYRFEQVAGSNDAVRVGITLRPHDLLVRPVAR 461 +A + + + +R G V R Sbjct: 394 VADHMPDLKPISAPERLRSGWLNGIKHWQVDYTGR 428 >3MGX-A nrPDB Length = 415 Score = 203 bits (515), Expect = 2e-52, Method: Composition-based stats. Identities = 68/362 (18%), Positives = 120/362 (33%), Gaps = 48/362 (13%) Query: 100 GKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDATSESF 159 G + + HR+ R+ + P A + E + R G+ DA + Sbjct: 102 GGRMMVVSEHEQHRKLRKLVGPLLSRAAARKLAERVRIEVGDVLGRVLDGEVCDAATAIG 161 Query: 160 RVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDA 219 + A C + G ++ + + L G + + P A Sbjct: 162 PR-IPAAVVCEILGVPAEDED--MLIDLTNHAFGGEDELFDGMTP------------RQA 206 Query: 220 LADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETI 279 ++ + DE+I RR + DDL++ L+ D + ++ +L G+ET Sbjct: 207 HTEILVYFDELITARRK--EPGDDLVSTLVT-----DDDLTIDDVLLNCDNVLIGGNETT 259 Query: 280 ASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVW 339 I + ALA P +RD V V+ E +R Sbjct: 260 RHAITGAVHALATVPGLLTALRDGSADV-----------------DTVVEEVLRWTSPAM 302 Query: 340 VLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYA 399 + R A+ + G +P+G ++ A RDP +DD F P R Sbjct: 303 HVLRVTTADVTINGRDLPSGTPVVAWLPAANRDPAEFDDPDTFLPGR---------KPNR 353 Query: 400 MKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRVGITLRPHDLLVRPV 459 F G C + +L+++ LA + + +R + +L VR Sbjct: 354 HITFGHGMHHCLGSALARIELSVVLRVLAERVSRVDLEREPAWLRAIVVQGYRELPVRFT 413 Query: 460 AR 461 R Sbjct: 414 GR 415 >5FYF-A nrPDB Length = 470 Score = 202 bits (514), Expect = 2e-52, Method: Composition-based stats. Identities = 80/468 (17%), Positives = 158/468 (33%), Gaps = 54/468 (11%) Query: 5 SVNPETRAPAAPGAPELREPPVAGGGV---------PLLGHGWRLARDPLAFMSQLRDHG 55 S +T P P + P + P L + A+ +LRD Sbjct: 37 SAKRKTFGPRRPMPEFVETPIPDVNTLALEDIDVSNPFLYRQGQWR----AYFKRLRDEA 92 Query: 56 DVVRIKLGPK-TVYAVTNPELTGALALNPDYHIAGPLWESLEGLLGKEGVAT--ANGPLH 112 V K P ++VT E + + D A P + G + P H Sbjct: 93 PVHYQKNSPFGPFWSVTRFEDILFVDKSHDLFSAEPQIILGDPPEGLSVEMFIAMDPPKH 152 Query: 113 RRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDATSESFRVAVRVAARCLLR 172 QR ++Q + ++ + + K + + + L Sbjct: 153 DVQRSSVQGVVAPKNLKEMEGLIRSRTGDVLDSLPTDKPFNWVPAVSK-ELTGRMLATLL 211 Query: 173 GQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDA--LADLHLLVDEI 230 +ER + + RM N F+DA +A + Sbjct: 212 DFPYEERHKLV---------EWSDRMAGAASATGGEFADENAMFDDAADMARSFSRLWRD 262 Query: 231 IAERRASGQKPDDLLTALLEAKDDNGDPIGE-QEIHDQVVAILTPGSETIASTIMWLLQA 289 RRA+G++P L +LL++ + D I E + ++ G++T +++ L A Sbjct: 263 KEARRAAGEEPGFDLISLLQSNKETKDLINRPMEFIGNLTLLIVGGNDTTRNSMSGGLVA 322 Query: 290 LADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAES 349 + + P ++++ + E + N++ E +R + + + R A + Sbjct: 323 MNEFPREFEKLKAKPELIP-----------------NMVSEIIRWQTPLAYMRRIAKQDV 365 Query: 350 ELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRK 409 ELGG I G ++ + RD + +D+ +F DR F G + Sbjct: 366 ELGGQTIKKGDRVVMWYASGNRDERKFDNPDQFIIDRKDARN--------HMSFGYGVHR 417 Query: 410 CPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRVGITLRPHDLLVR 457 C + + QL ++ + ++ +V + V+ L+V+ Sbjct: 418 CMGNRLAELQLRILWEEILKRFDNIEVVEEPERVQSNFVRGYSRLMVK 465 >5XJN-A nrPDB Length = 455 Score = 201 bits (510), Expect = 7e-52, Method: Composition-based stats. Identities = 61/412 (14%), Positives = 121/412 (29%), Gaps = 55/412 (13%) Query: 43 DPLAFMSQLRDHGDVVRIKLGPKTVYAVTNPELTGALALNPDYHIA--------GPLWES 94 +P +LR V+ + + VT + + + + ++ Sbjct: 63 NPFPAYKELRQEEPVMFDERIGY--WVVTKYDDIKTTFDDWETFSSENAQAPVRKRGPQA 120 Query: 95 LEGLLGKE-----GVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEA-HALTERWQP 148 + + G++ P H R R Q AF A P + + + Sbjct: 121 TQIMTDGGFTAYSGLSARIPPEHTRIRAIAQKAFTPRRYKALEPDIRAMVIDRVEKMLAN 180 Query: 149 GKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRL 208 + V + L G + R + Sbjct: 181 DQHVGDMVSDLAYDIPTITILTLIGADISMVDTYKR-------WSDSRAAMTWGDLSDEE 233 Query: 209 PLPANRRFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQV 268 +P + + +V + A D+L L+ A+ + G I + EI + Sbjct: 234 QIPHAHNLVEYWQECQRMVAD------AHAHGGDNLTADLVRAQQE-GQEITDHEIASLL 286 Query: 269 VAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVI 328 ++L G ET + I + L DHPE I + + + + Sbjct: 287 YSLLFAGHETTTTLISNCFRVLLDHPEQWQAILENPKLIP-----------------AAV 329 Query: 329 VEAMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWL 388 E +R ++ R+A+ ++E+GG I G ++ + RD +++ EFD R Sbjct: 330 DEVLRYSGSIVGWRRKALKDTEIGGVAIKEGDGVLLLMGSANRDEARFENGEEFDISR-- 387 Query: 389 PERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSN 440 F G C + + Q + + + Sbjct: 388 ------ANAREHLSFGFGIHYCLGNMLAKLQAKICLEEVTRLVPSLHLVADK 433 >5GWE-A nrPDB Length = 405 Score = 201 bits (510), Expect = 8e-52, Method: Composition-based stats. Identities = 61/412 (14%), Positives = 121/412 (29%), Gaps = 55/412 (13%) Query: 43 DPLAFMSQLRDHGDVVRIKLGPKTVYAVTNPELTGALALNPDYHIA--------GPLWES 94 +P +LR V+ + + VT + + + + ++ Sbjct: 13 NPFPAYKELRQEEPVMFDERIGY--WVVTKYDDIKTTFDDWETFSSENAQAPVRKRGPQA 70 Query: 95 LEGLLGKE-----GVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEA-HALTERWQP 148 + + G++ P H R R Q AF A P + + + Sbjct: 71 TQIMTDGGFTAYSGLSARIPPEHTRIRAIAQKAFTPRRYKALEPDIRAMVIDRVEKMLAN 130 Query: 149 GKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRL 208 + V + L G + R + Sbjct: 131 DQHVGDMVSDLAYDIPTITILTLIGADISMVDTYKR-------WSDSRAAMTWGDLSDEE 183 Query: 209 PLPANRRFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQV 268 +P + + +V + A D+L L+ A+ + G I + EI + Sbjct: 184 QIPHAHNLVEYWQECQRMVAD------AHAHGGDNLTADLVRAQQE-GQEITDHEIASLL 236 Query: 269 VAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVI 328 ++L G ET + I + L DHPE I + + + + Sbjct: 237 YSLLFAGHETTTTLISNCFRVLLDHPEQWQAILENPKLIP-----------------AAV 279 Query: 329 VEAMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWL 388 E +R ++ R+A+ ++E+GG I G ++ + RD +++ EFD R Sbjct: 280 DEVLRYSGSIVGWRRKALKDTEIGGVAIKEGDGVLLLMGSANRDEARFENGEEFDISR-- 337 Query: 389 PERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSN 440 F G C + + Q + + + Sbjct: 338 ------ANAREHLSFGFGIHYCLGNMLAKLQAKICLEEVTRLVPSLHLVADK 383 >1WIY-A nrPDB Length = 389 Score = 200 bits (509), Expect = 9e-52, Method: Composition-based stats. Identities = 103/429 (24%), Positives = 160/429 (37%), Gaps = 56/429 (13%) Query: 31 VPLLGHGWRLARDPLAFMSQLRDHGDVVRIKLGPKTVYAVTNPELTGALALNPDYHIAGP 90 P L L +DPLA + + + + L + + +PE L A Sbjct: 10 WPYLK---DLQQDPLAVLLEWGRAHPRLFLPLPRFPLALIFDPEGVEGALLAEGTTKATF 66 Query: 91 LWESLEGLLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGK 150 + +L L G+ G+ T G + R+ ++ F ++ Y MEEEA A W+ G+ Sbjct: 67 QYRALSRLTGR-GLLTDWGKSWKEARKALKDPFLPKSVRGYREAMEEEAWAFFGEWR-GE 124 Query: 151 TVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPL 210 D E +++R+ R L AE AL + M PL L L Sbjct: 125 ERDLDHEMLALSLRLLGRALFGKPLSPSLAEHALKALDRI-------MAQTRSPLALLDL 177 Query: 211 PANRRFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVA 270 A RF L+ + +I S + + + V Sbjct: 178 AAEARFRKDRGALYREAEALIVHPPLSH--------------------LPRERALSEAVT 217 Query: 271 ILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVE 330 +L G ET+AS + W L+ P+ R+ E Sbjct: 218 LLVAGHETVASALTWSFLLLSHRPDWQKRV-----------------AESEEAALAAFQE 260 Query: 331 AMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPE 390 A+RL P W+LTRR LG R+P G ++ SPY QR + + F P+R+L E Sbjct: 261 ALRLYPPAWILTRRLERPLLLGEDRLPQGTTLVLSPYVTQR--LYFPEGEAFQPERFLAE 318 Query: 391 RAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRVGITLR 450 R P PF G+R C F++ + ++ A ++R + + V +TLR Sbjct: 319 RGT--PSGRYFPFGLGQRLCLGRDFALLEGPIVLRAFFRRFRLDPLPFPR--VLAQVTLR 374 Query: 451 PH-DLLVRP 458 P L RP Sbjct: 375 PEGGLPARP 383 >2XKR-A nrPDB Length = 398 Score = 198 bits (503), Expect = 5e-51, Method: Composition-based stats. Identities = 66/408 (16%), Positives = 137/408 (33%), Gaps = 50/408 (12%) Query: 48 MSQLRDHGDVVRIKLGPKTVYAVTNPELTGALALNPDYHIAGPLWESLEGLLGKEGVATA 107 +R + V R + G + A + + P+ + L + Sbjct: 24 YRWMRANQPVFRDRNG---LAAASTYQAVIDAERQPELFSNAGGIRPDQPAL--PMMIDM 78 Query: 108 NGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDATSESFRVAVRVAA 167 + P H +R+ + F + + L + D + + +A Sbjct: 79 DDPAHLLRRKLVNAGFTRKRVKDKEASIAALCDTLIDAVCERGECDFVRDL-AAPLPMAV 137 Query: 168 RCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALADLHLLV 227 + G ++R +F +V L + + DA A + Sbjct: 138 IGDMLGVRPEQRD---------MFLRWSDDLVTFLSS--HVSQEDFQITMDAFAAYNDFT 186 Query: 228 DEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLL 287 IA RRA DDL++ L+ ++ D G+ + + E+ + + IL G ET T+ Sbjct: 187 RATIAARRA--DPTDDLVSVLVSSEVD-GERLSDDELVMETLLILIGGDETTRHTLSGGT 243 Query: 288 QALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVA 347 + L + + D ++ + + G I E +R V + R A Sbjct: 244 EQLLRNRDQWDLLQRDPSLLPG-----------------AIEEMLRWTAPVKNMCRVLTA 286 Query: 348 ESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGK 407 ++E G + AG ++ + D + + +FD R + F G Sbjct: 287 DTEFHGTALCAGEKMMLLFESANFDEAVFCEPEKFDVQR---------NPNSHLAFGFGT 337 Query: 408 RKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRVGITLRPHDLL 455 C + + +L+L+T + + ++ + + LRP + + Sbjct: 338 HFCLGNQLARLELSLMTERVLRRLPDLRLVADD----SVLPLRPANFV 381 >5DE9-A nrPDB Length = 410 Score = 196 bits (498), Expect = 2e-50, Method: Composition-based stats. Identities = 82/429 (19%), Positives = 134/429 (31%), Gaps = 62/429 (14%) Query: 41 ARDPLAFMSQLRDHGDVVRIKLGPKT--VYAVTNPELTGALALNPDY---HIAGPLWESL 95 D +++L G V RI L + VT + + +P + + L Sbjct: 23 GSDFDPVLTELMREGPVTRISLPNGEGWAWLVTRHDDVRLVTNDPRFGREAVMDRQVTRL 82 Query: 96 EGLLG--KEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTE-RWQPGKTV 152 + V + P H R RR++ AF + L + + G Sbjct: 83 APHFRPARGAVGFLDPPDHTRLRRSVAAAFTARGVERVRERSRGMLDELVDAMLRAGPPA 142 Query: 153 DATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPA 212 D T +A C L G +R + V Sbjct: 143 DLTEAVLS-PFPIAVICELMGVPATDRHS--MHTWTQLILSSSHGAEVS----------- 188 Query: 213 NRRFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAIL 272 A +++ ++I R S +D+ + L A D I E V + Sbjct: 189 ----ERAKNEMNAYFSDLIGLR--SDSAGEDVTSLLGAAVGR--DEITLSEAVGLAVLLQ 240 Query: 273 TPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAM 332 G E + + + L PE A+R+R E E I E + Sbjct: 241 IGG-EAVTNNSGQMFHLLLSRPELAERLRSEPEIRP-----------------RAIDELL 282 Query: 333 RLRPA--VWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPE 390 R P L+R A+ + E+ G RI AG + S A RDP+ + D D +R Sbjct: 283 RWIPHRNAVGLSRIALEDVEIKGVRIRAGDAVYVSYLAANRDPEVFPDPDRIDFER---- 338 Query: 391 RAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRVG---I 447 F G CP + + L+ A+ + ++A + + V + Sbjct: 339 -----SPNPHVSFGFGPHYCPGGMLARLESELLVDAVLDRVPGLKLAVAPEDVPFKKGAL 393 Query: 448 TLRPHDLLV 456 P L V Sbjct: 394 IRGPEALPV 402 >3P3Z-A nrPDB Length = 416 Score = 196 bits (497), Expect = 2e-50, Method: Composition-based stats. Identities = 73/360 (20%), Positives = 122/360 (33%), Gaps = 43/360 (11%) Query: 99 LGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDATSES 158 + + + +G HRR R F I A P + L ++ G + Sbjct: 95 FMVDFLQSLDGADHRRLRGLATHPFTPRRITAVQPFVRSTVEQLIDKLPQGDF--DFVQH 152 Query: 159 FRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFND 218 F + C L G +++ +++ LG + Sbjct: 153 FPHPLPALVMCQLLGFPLEDYDTVGRLSIE-----------TNLGLALSNDQDILVKVEQ 201 Query: 219 ALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSET 278 L + + I +R+ + DDL + ++ A D + + E+ V +L G ET Sbjct: 202 GLGRMFDYLVAAIEKRKV--EPGDDLTSDIVRAFHDG--VLDDYELRTLVATVLVAGYET 257 Query: 279 IASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAV 338 + + A HP+ +I++ E + E +R P + Sbjct: 258 TNHQLALAMYDFAQHPDQWMKIKENPELAP-----------------QAVEEVLRWSPTL 300 Query: 339 WVL-TRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPK 397 V TR A + E+ G RIP G + + RDP+ + D FD +R A Sbjct: 301 PVTATRVAAEDFEVNGVRIPTGTPVFMCAHVAHRDPRVFADADRFDIT---VKREAPS-- 355 Query: 398 YAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRVGITLRPHDLLVR 457 F G C + +LT AALAT+ Q+AG P L +R Sbjct: 356 ---IAFGGGPHFCLGTALARLELTEAVAALATRLDPPQIAGEITWRHELGVAGPDALPLR 412 >5Z9I-A nrPDB Length = 398 Score = 195 bits (495), Expect = 3e-50, Method: Composition-based stats. Identities = 69/414 (16%), Positives = 136/414 (32%), Gaps = 42/414 (10%) Query: 35 GHGWRLARDPLAFMSQLRDHGDVVRIKLGPKTVYAVTNPELTGALALNPDYHIAGPLWES 94 GH W + P + + + + P++ ++NP++ + + D Sbjct: 14 GHFWMRGKRPDK-IVDYDEELQLWNVYGYPESAAILSNPKVFSSDTMRLDPIK------- 65 Query: 95 LEGLLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDA 154 L+ + + A + P HRR R + AF + + H L + + D Sbjct: 66 LDEAIVEGDFAHTDPPKHRRLRGLVDHAFTPSLVAKMESRVHGIIHELLDGVEGKSQFDL 125 Query: 155 TSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANR 214 +E F + + L G +RA + + G + Sbjct: 126 VAE-FAAPLPLIMISDLLGVPESDRAL-FRQWMDKMLDGSEK---FESPETVLEQEEELH 180 Query: 215 RFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTP 274 + + L ++ E AE R + +DL++ L+ A+ D G + + +I + +L Sbjct: 181 KELELLWEMRDYWHERAAESRK--RPREDLISQLVHAEVD-GQKLNDSQISNIANRLLVN 237 Query: 275 GSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRL 334 G T A I + L + R+R + V ++ E+MR Sbjct: 238 GHLTTAMLIANTMLCLDAFSDQDARVRADRSLVP-----------------ALLEESMRY 280 Query: 335 RPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAAN 394 + + R +E E+ G IP ++ A RD + ++ FD R Sbjct: 281 MSPICGVGRATNSEVEVAGTVIPKDQLLLVWTGAANRDERQFEKPDVFDAGR-------- 332 Query: 395 VPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRVGIT 448 A F G C + + L + + +N + + Sbjct: 333 -SPNAHLGFGRGIHFCLGRQLARMESKAAVEILLDRLPTLRADPANPPTFLQVV 385 >2FR7-A nrPDB Length = 412 Score = 193 bits (491), Expect = 1e-49, Method: Composition-based stats. Identities = 81/452 (17%), Positives = 138/452 (30%), Gaps = 56/452 (12%) Query: 15 APGAPELREPPVAGGGVPLLG---HGWRLARDPLAFMSQLRDHGDVVRIKLGPKTVYAVT 71 AP + P G GVP LG DP LR+ G V + L VY V Sbjct: 4 APSLVPVTTPSQHGAGVPHLGIDPFALDYFADPYPEQETLREAGPV--VYLDKWNVYGVA 61 Query: 72 NPELTGALALNPDYHIAGP-----LWESLEGLLGKEGVATANGPLHRRQRRTIQPAFRLD 126 A+ +P + ++ + + A+ P H R R + Sbjct: 62 RYAEVYAVLNDPLTFCSSRGVGLSDFKKEKPWRPPSLILEADPPAHTRTRAVLSKVLSPA 121 Query: 127 AIPAYGPIMEEEAHALTERW-QPGKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCV 185 + A A + G +DA ++ + Sbjct: 122 TMKRLRDGFAAAADAKIDELLARGGNIDAIADLAEA-----------------YPLSVFP 164 Query: 186 ALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQKPDDLL 245 + + ++ G ++ P N A+ + + + P Sbjct: 165 DAMGLKQEGRENLLPYAGLVFNAFGPPNELRQSAIERSAPHQAYVAEQCQRPNLAPGGF- 223 Query: 246 TALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVE 305 A + A D G+ I +E V ++L+ G +T + I + LA P+ R+R + Sbjct: 224 GACIHAFSDTGE-ITPEEAPLLVRSLLSAGLDTTVNGIAAAVYCLARFPDEFARLRADPS 282 Query: 306 AVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYS 365 N EA+R V R + EL G I G ++ Sbjct: 283 L-----------------ARNAFEEAVRFESPVQTFFRTTTRDVELAGATIGEGEKVLMF 325 Query: 366 PYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITA 425 + RDP+ +DD +D R F +G C + + ++ A Sbjct: 326 LGSANRDPRRWDDPDRYDITR---------KTSGHVGFGSGVHMCVGQLVARLEGEVVLA 376 Query: 426 ALATKYRFEQVAGSNDAVRVGITLRPHDLLVR 457 ALA K ++AG L ++ Sbjct: 377 ALARKVAAIEIAGPLKRRFNNTLRGLESLPIQ 408 >1Q5D-A nrPDB Length = 419 Score = 193 bits (489), Expect = 2e-49, Method: Composition-based stats. Identities = 70/405 (17%), Positives = 139/405 (34%), Gaps = 53/405 (13%) Query: 40 LARDPLAFMSQLRDHGDVVRIKLGPKTVYAVTNPELTGALALNPDYHIAGPLWESLEGL- 98 A DP + +LR+ + G + +T A+ + + ++ WES Sbjct: 24 YAEDPFPAIERLREATPIFYWDEG--RSWVLTRYHDVSAVFRDERFAVSREEWESSAEYS 81 Query: 99 --------LGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGK 150 + K G+ H R R+ + P+F AI ++ L + + Sbjct: 82 SAIPELSDMKKYGLFGLPPEDHARVRKLVNPSFTSRAIDLLRAEIQRTVDQLLDARSGQE 141 Query: 151 TVDATSESFRVAVRVAARCLLRGQYM--DERAERLCVALATVFRGMYRRMVVPLGPLYRL 208 D + + + + A L DE+ R G + +G + R+ Sbjct: 142 EFDVVRD-YAEGIPMRAISALLKVPAECDEKFRRF---------GSATARALGVGLVPRV 191 Query: 209 PLPANRRFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQV 268 + ++ + L+ ++ ERR + + +D+LT LL+A+ +G + +E+ V Sbjct: 192 DEET-KTLVASVTEGLALLHGVLDERRRNPLE-NDVLTMLLQAE-ADGSRLSTKELVALV 248 Query: 269 VAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVI 328 AI+ G++T I + + L PE + ++ E N + Sbjct: 249 GAIIAAGTDTTIYLIAFAVLNLLRSPEALELVKAEPGL-----------------MRNAL 291 Query: 329 VEAMRLRPAVWV-LTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRW 387 E +R + + R A + E G I G + + RD + FD R Sbjct: 292 DEVLRFDNILRIGTVRFARQDLEYCGASIKKGEMVFLLIPSALRDGTVFSRPDVFDVRR- 350 Query: 388 LPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYR 432 A + G CP + + + + ++ Sbjct: 351 --------DTSASLAYGRGPHVCPGVSLARLEAEIAVGTIFRRFP 387 >6M7L-A nrPDB Length = 404 Score = 192 bits (488), Expect = 3e-49, Method: Composition-based stats. Identities = 71/402 (17%), Positives = 126/402 (31%), Gaps = 65/402 (16%) Query: 53 DHGDVVRIKL--GPKTVYAVTNPELTGALALNPDYHIA-GPLWESLEGLLGKEGVATANG 109 + G +VRI L G + ++ + + + + + + + + Sbjct: 46 ERGPLVRIPLEDGSAVHWFALGYDVVREVLGSEKFDKRVIGTHFNHQEMALPGNLLQLDP 105 Query: 110 PLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDATSESFRVAVRVAAR- 168 P H R RR + PA+ + + A P ++ + VA +AAR Sbjct: 106 PEHTRLRRMVAPAYSVRRMQALEPRVQAIVDDHLDTMASTGP--PVEFLREVAGPMAARV 163 Query: 169 -CLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALADLHLLV 227 C G +D+R E + + RR + A L + Sbjct: 164 ACEFLGIPLDDRGELIRLTAHR--------------------GGKRRRVLNGHAYL-AYM 202 Query: 228 DEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLL 287 E+ A R D +L + D+G I ++E+ ++ E S + Sbjct: 203 RELAARLRR--DPGDGMLGMVAR---DHGADISDEELAGLCAVVMNSSVEQTESCLAAGT 257 Query: 288 QALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVL-TRRAV 346 L +HPE +R+ E + E +R L R A Sbjct: 258 LLLLEHPEQFALLRERPEL-----------------GEQAVEEIVRYLSVFEGLDPRTAT 300 Query: 347 AESELGGYRIPAGADIIYSPYAIQR-DPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSA 405 + E+GG I G + S A R DP FD R + F Sbjct: 301 EDVEIGGQVIKKGEAVFCSLLAANRADPAL----DGFDITR---------KESRHVAFGH 347 Query: 406 GKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRVGI 447 G C + +L + L +++ + A + +R Sbjct: 348 GIHHCLGAPLARMELRIAFTTLVSRFPSLRTAVPAEEIRFRP 389 >4PWV-A nrPDB Length = 446 Score = 192 bits (488), Expect = 3e-49, Method: Composition-based stats. Identities = 73/423 (17%), Positives = 135/423 (31%), Gaps = 51/423 (12%) Query: 42 RDPLAFMSQLRDHGDVVRIKLGPK--TVYAVTNPELTGALALNPDYHIAGPLWESLEGLL 99 D + QLR + + V+ AL + + + L Sbjct: 49 NDLSEYWRQLRTTRPLYWHPPVGDAPGFWVVSRYADVMALYKDNKKLTSEKGNVLVTLLA 108 Query: 100 GKEG-----VATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDA 154 G + +A +G +HR R + +F A+ + L D Sbjct: 109 GGDSAAGKMLAVTDGAMHRGLRNVLLKSFSPQALKPIVDQIRVNTTRLVVDAARRGECDF 168 Query: 155 TSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANR 214 ++ + + L G +R L + + + + Sbjct: 169 AADVAE-QIPLNTISDLLGVPAADREFLLKLNKSALSSEDADQSATDAWL---------- 217 Query: 215 RFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTP 274 A ++ L E++AERRA + +D+++ L + D G P+ E+ I +++ Sbjct: 218 ----ARNEILLYFSELVAERRA--KPTEDVISVLANSMVD-GKPLTEEVIVLNCYSLILG 270 Query: 275 GSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRL 334 G ET +++ +Q +P+ + +RD + E +R Sbjct: 271 GDETSRLSMIDSVQTFTQYPDQWELLRDGKVT-----------------LESATEEVLRW 313 Query: 335 RPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAAN 394 RRAV + EL G I AG + + RD + + D FD +R Sbjct: 314 ATPAMHFGRRAVTDMELHGQVIAAGDVVTLWNNSANRDEEVFADPYAFDLNR-------- 365 Query: 395 VPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRVGITLRPHDL 454 F G C + A++ + AL T ++ G + L Sbjct: 366 -SPNKHITFGYGPHFCLGAYLGRAEVHALLDALRTYTTGFEITGEPQRIHSNFLTGLSRL 424 Query: 455 LVR 457 VR Sbjct: 425 PVR 427 >3A1L-A nrPDB Length = 425 Score = 190 bits (482), Expect = 1e-48, Method: Composition-based stats. Identities = 77/402 (19%), Positives = 121/402 (30%), Gaps = 56/402 (13%) Query: 43 DPLAFMSQLRDHGDVVRIKLGP------------KTVYAVTNPELTGALALNPDYHIAGP 90 DP + R+ V R GP V ++N L + P Sbjct: 21 DPYPVYRRYREAAPVHRTASGPGKPDTYYVFTYDDVVRVLSNRRLGRNARVASGDTDTAP 80 Query: 91 LWESLEGLLGKEGV----ATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERW 146 + E + V + P H R + F + P + E A AL +R Sbjct: 81 VPIPTEHRALRTVVENWLVFLDPPHHTELRSLLTTEFSPSIVTGLRPRIAELASALLDRL 140 Query: 147 QPGKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLY 206 + + D F + + L G ++ A+A R Sbjct: 141 RAQRRPDLVEG-FAAPLPILVISALLGIPEEDHTWLRANAVALQEASTTRA--------- 190 Query: 207 RLPLPANRRFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHD 266 R A + + R + LT L+ A+ D G P+ I Sbjct: 191 -RDGRGYARAEAASQEFTRYFRREVDRRGGDDRDDL--LTLLVRAR-DTGSPLSVDGIVG 246 Query: 267 QVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGN 326 V +LT G ET + + + L H + D +R E+ Sbjct: 247 TCVHLLTAGHETTTNFLAKAVLTLRAHRDVLDELRTTPESTP-----------------A 289 Query: 327 VIVEAMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDR 386 + E MR P V +TR A + LG + IP G+ ++ + RDP + D D R Sbjct: 290 AVEELMRYDPPVQAVTRWAYEDIRLGDHDIPRGSRVVALLGSANRDPARFPDPDVLDVHR 349 Query: 387 WLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALA 428 F G C + A+ + AL Sbjct: 350 ---------AAERQVGFGLGIHYCLGATLARAEAEIGLRALL 382 >3OO3-A nrPDB Length = 384 Score = 189 bits (480), Expect = 2e-48, Method: Composition-based stats. Identities = 75/424 (17%), Positives = 144/424 (33%), Gaps = 61/424 (14%) Query: 39 RLARDPLAFMSQLRDHGDVVRIK----LGPKTVYAVTNPELTGALALNPDYHIA-GPLWE 93 RL DP+ +L+ G + + + + VT + A+ + + + P+ + Sbjct: 9 RLRLDPVPEFEELQKAGPLHEYDTEPGMDGRKQWLVTGHDEVRAILADHERFSSMRPVDD 68 Query: 94 SLEGLLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVD 153 + L + + P H R RRT+ PA+ + P +EE + ++ Sbjct: 69 EADRALLPGILQAYDPPDHTRLRRTVAPAYSARRMERLRPRIEEIVEECLDDFESVGAPV 128 Query: 154 ATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPAN 213 + C G D++AE L+ + R RLP Sbjct: 129 DFVRHAAWPIPAYIACEFLGVPRDDQAE-----LSRMIRESRES---------RLP---- 170 Query: 214 RRFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILT 273 R+ + + + + +R D ++ ++ ++G I ++E+ L Sbjct: 171 RQRTLSGLGIVNYTKRLTSGKRR--DPGDGMIGVIVR---EHGAEISDEELAGLAEGNLI 225 Query: 274 PGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMR 333 +E +A+ + + L HP+ +R++ E + + E +R Sbjct: 226 MAAEQMAAQLAVAVLLLVTHPDQMALLREKPELI-----------------DSATEEVLR 268 Query: 334 LRPAVWV-LTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERA 392 V R A+A+ + G I AG + S A R P FD R Sbjct: 269 HASIVEAPAPRVALADVRMAGRDIHAGDVLTCSMLATNRAP-----GDRFDITR------ 317 Query: 393 ANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRVGITLRPH 452 K F G C + QL + A+ ++ ++A + +R RP Sbjct: 318 ---EKATHMAFGHGIHHCIGAPLARLQLRVALPAVVGRFPSLRLAVPEEDLRFKPG-RPA 373 Query: 453 DLLV 456 V Sbjct: 374 PFAV 377 >2UUQ-A nrPDB Length = 414 Score = 189 bits (479), Expect = 2e-48, Method: Composition-based stats. Identities = 74/430 (17%), Positives = 133/430 (30%), Gaps = 55/430 (12%) Query: 43 DPLAFMSQLRDHGDVVRIKLGPKT---VYAVTNPELTGALALNPDYHIAGPLWES----- 94 +P LRDH V + + Y ++ + A + + Sbjct: 26 NPWPMYRALRDHDPVHHVVPPQRPEYDYYVLSRHADVWSAARDHQTFSSAQGLTVNYGEL 85 Query: 95 -LEGLLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVD 153 + GL + + P+H R+ + F + P + + E+ + D Sbjct: 86 EMIGLHDTPPMVMQDPPVHTEFRKLVSRGFTPRQVETVEPTVRKFVVERLEKLRANGGGD 145 Query: 154 ATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPAN 213 +E F+ + G ++ T F G + +V A Sbjct: 146 IVTELFK-PLPSMVVAHYLGVPEED---------WTQFDGWTQAIVAA-----NAVDGAT 190 Query: 214 RRFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKD-DNGDPIGEQEIHDQVVAIL 272 DA+ + +I RR + DD ++ L+ A +GD G I ++ Sbjct: 191 TGALDAVGSMMAYFTGLIERRRT--EPADDAISHLVAAGVGADGDTAGTLSILAFTFTMV 248 Query: 273 TPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAM 332 T G++T+ + + L P+ + D+ E + + E + Sbjct: 249 TGGNDTVTGMLGGSMPLLHRRPDQRRLLLDDPEGIPD-----------------AVEELL 291 Query: 333 RLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSY-DDNLEFDPDRWLPER 391 RL V L R + +G IPAG ++ + RD + Y D E D R Sbjct: 292 RLTSPVQGLARTTTRDVTIGDTTIPAGRRVLLLYGSANRDERQYGPDAAELDVTR----- 346 Query: 392 AANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKY-RFEQVAGSNDAVRVGITLR 450 + FS G C + Q + L + FE R Sbjct: 347 ----CPRNILTFSHGAHHCLGAAAARMQCRVALTELLARCPDFEVAESRIVWSGGSYVRR 402 Query: 451 PHDLLVRPVA 460 P + R + Sbjct: 403 PLSVPFRVTS 412 >6HQW-A nrPDB Length = 445 Score = 188 bits (478), Expect = 3e-48, Method: Composition-based stats. Identities = 59/355 (16%), Positives = 118/355 (33%), Gaps = 41/355 (11%) Query: 102 EGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDATSESFRV 161 + P H QRRT+ PAF + + ++ + G+ D + Sbjct: 127 PMFIAMDRPDHTGQRRTVAPAFTPAKMVEMEAEIRRRTASVLDSLPWGERFDWVDKVSIE 186 Query: 162 AVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALA 221 L + D R A R + + L Sbjct: 187 LTTGMLAILFGFPWADRRLLTFWSDWAGDVELTLARELADTRFGF-------------LG 233 Query: 222 DLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIAS 281 ++ + R + DL++ ++ + + + + QE +V ++ G++T + Sbjct: 234 EMAHYFQRLWGARMQAP-PSGDLISMMIHS--EAMNHMSPQEFMGNLVLLIVGGNDTTRN 290 Query: 282 TIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVL 341 T+ ++ AL P+ + + + + N + E +R + + Sbjct: 291 TMSGIVHALDKFPDQRELLERDASLIP-----------------NAVQECIRYVTPLAHM 333 Query: 342 TRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMK 401 R A A++EL G +I AG +I + RD +++ + DR R Sbjct: 334 RRTATADTELFGNQIKAGEKVILWYISANRDETVFENPDKLMVDRPNARR--------HL 385 Query: 402 PFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRVGITLRPHDLLV 456 F G +C + QL ++ + + +VAG + VR L V Sbjct: 386 SFGHGIHRCVGARLAELQLRILLEEMHERRMRVRVAGEVERVRANFVHGFRKLEV 440 >6HQD-A nrPDB Length = 420 Score = 188 bits (477), Expect = 5e-48, Method: Composition-based stats. Identities = 69/422 (16%), Positives = 145/422 (34%), Gaps = 41/422 (9%) Query: 36 HGWRLARDPLAFMSQLRDHGDVVRIKLGPKTVYAVTNPELTGALALNPDYHIAGPLWESL 95 + RL R+ + ++G I V TN ++ + N + + ++ Sbjct: 37 YFERLRREDPVHYCKASEYGPYWSITKFSDIVAIDTNHKVFSSDHTNGSFVLDDTTLNAV 96 Query: 96 EGLLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDAT 155 +G + + P H R + P + + + E + G+ + Sbjct: 97 DGGIYLPNFLGMDPPKHDVHRMVVSPIVAPQNLLRFEATIRERTKRVLSELPIGEEFNWV 156 Query: 156 SESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRR 215 + + + L D+R + + ++ P Y L +R Sbjct: 157 -DRVSIELTTMMLATLLDFPFDDRRKL----------TRWSDIIT-TRPGYGLVDSWEQR 204 Query: 216 FNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPG 275 ++ + L + AER+A KP DL++ L A + + + ++ G Sbjct: 205 ESELMECL-AYFQRLYAERQAMPPKP-DLISML--AHSPEMQDLTPTDFLGTLALLIVGG 260 Query: 276 SETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLR 335 ++T S++ A +P+ D++R+ +VI E +R + Sbjct: 261 NDTTRSSMSGSAMACHLYPQEFDKVRNNRAL-----------------LASVIPEVVRWQ 303 Query: 336 PAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANV 395 + + R A+ + E G +I G ++ + RD + D ++F DR Sbjct: 304 TPIAHMRRTALEDVEFRGKQIRKGDKVVMWYLSGNRDDEVIDRPMDFIADR--------P 355 Query: 396 PKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRVGITLRPHDLL 455 F G +C + + QL ++ + +Y +V G V + D+ Sbjct: 356 RARHHLSFGFGIHRCLGNRLAELQLKILWEEMCERYSRIEVCGEPVRVPSNLVHGYIDIP 415 Query: 456 VR 457 VR Sbjct: 416 VR 417 >5D3U-A nrPDB Length = 427 Score = 188 bits (476), Expect = 5e-48, Method: Composition-based stats. Identities = 78/413 (18%), Positives = 128/413 (30%), Gaps = 55/413 (13%) Query: 43 DPLAFMSQLRDHGDVVRIKLGPKTVYAVTNPELTGALALNPDYHIAGPLWESLEGLLG-- 100 DP + L V ++ +AV A +P G Sbjct: 36 DPYPVYADLAQRRPVHWVE--RLNAWAVLTYADCAAGLKDPRLTADRGTEVLAAKFPGQP 93 Query: 101 -----------KEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPG 149 K V + PLH RR+++ F A Y ++++ AH L G Sbjct: 94 LPPDNIFHRWTKNVVMYTDPPLHDALRRSVRAGFTRAAHQHYDQVLQKVAHDLVASIPAG 153 Query: 150 KTVDATSESFRVAVRVAARCLLRGQYMDERAERL--CVALATVFRGMYRRMVVPLGPLYR 207 T + + V + G ++ + + T F G + V Sbjct: 154 ATEIDAVPALAAELPVRSAVHAFGVPEEDLGFLIPRVNTIMTYFSGPKDQPVT------- 206 Query: 208 LPLPANRRFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQ 267 + L DLH E++ R PD ++ L A+D + EQ +H Sbjct: 207 -----QEIILEKLTDLHTYASELLQGMR-GKVLPDTVIARLAAAQDGLTETTPEQTVHQL 260 Query: 268 VVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNV 327 + + + T ++ A A +P +R + V N Sbjct: 261 ALVFIALFAPTTPGSLSSGTLAFARNPRQVERFLADQACV-----------------DNT 303 Query: 328 IVEAMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRW 387 E +R + R A + E+GG RI AG + + RD ++ +FD DR Sbjct: 304 ANEVLRYNASNQFTWRVAAKDVEMGGVRIEAGQTLALFLGSANRDANMFERPNDFDLDRP 363 Query: 388 LPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSN 440 R F G C + QL AL ++ + AG Sbjct: 364 NSAR--------HLSFGQGVHACLAAQLISLQLKWFYVALLNRFPGIRTAGEP 408 >6DCD-A nrPDB Length = 424 Score = 186 bits (473), Expect = 1e-47, Method: Composition-based stats. Identities = 83/411 (20%), Positives = 131/411 (31%), Gaps = 68/411 (16%) Query: 43 DPLAFMSQLRDHGDVVRIKLGPKTVYAVTNPELTGALALNPDYH-----IAGPLWESLEG 97 DP + LR V+R L V AVT E A+ + D + GP Sbjct: 18 DPHPYFDYLRSQSPVLR--LPQYGVVAVTGYEEATAVYKDTDSFSNCVALGGPFPPLPFA 75 Query: 98 LLGKEG----------------VATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHA 141 G + + T + P H R R + + M A Sbjct: 76 PNGDDVNAQIDAHREQFPMYEHMVTMDPPEHSRARSILSRLLTPSRLKQNEEFMWRLADR 135 Query: 142 LTERWQPGKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVF--RGMYRRMV 199 + + + SE + L G D+R + V A G Sbjct: 136 QLDEFLGAGECEFISE-YAKPFATLVIADLLGVPEDDRKDFRVVLGADRMGRVGALDHES 194 Query: 200 VPLGPLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPI 259 V + PL L I +RR Q +D+LTAL A +G Sbjct: 195 VGVNPLQW---------------LDDKFSAYIEDRRR--QPRNDVLTALATATYPDGSTP 237 Query: 260 GEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVR 319 ++ + G ET A + ++ L D P+ R+R+ + Sbjct: 238 EVIDVVRSATFLFAAGQETTAKLLTAAMRVLGDRPDIQRRLRENRSLIP----------- 286 Query: 320 KLRHTGNVIVEAMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDN 379 N I E++R+ V +R A + +GG I AG ++ P A RDP+ ++D Sbjct: 287 ------NFIEESLRMDSPVKSDSRLARKRTTVGGLDIAAGTVVMVLPGAANRDPRRFEDP 340 Query: 380 LEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATK 430 EF DR F+ G CP + + + + + Sbjct: 341 HEFRLDRPNVRE--------HMAFARGVHSCPGGPLARVEGRVSLERILDR 383 >6FYJ-A nrPDB Length = 421 Score = 186 bits (472), Expect = 2e-47, Method: Composition-based stats. Identities = 67/428 (15%), Positives = 139/428 (32%), Gaps = 47/428 (10%) Query: 34 LGHGWRLARDPLAFMSQLRDH--GDVVRIKLGPKTVYAVTNPELTGALALNPDY-HIAGP 90 + WRL + ++ R D+ +L K + E + Sbjct: 15 IDSTWRLMEEGYMYILNRRHSFNSDIFETRLLGKKAICMGGKEAAEIFYDTEKFKRKDAA 74 Query: 91 LWESLEGLLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGK 150 ++ L GK GV +G H+ ++ D + I +++ ++W+ Sbjct: 75 PNRVVQTLFGKNGVQALDGQTHKHRKEMFMSIMSPDELEKLTDITKKQWEIAVDKWEQMD 134 Query: 151 TVDATSESFRVAVRVAARCLLRGQYMDERA-ERLCVALATVFRGMYRRMVVPLGPLYRLP 209 V E+ + R A C G + E +RL L +F + Sbjct: 135 KVILYEEAKEIMCRTA--CQWAGVPVQENEVKRLTKNLGAMFESAAAVGL---------- 182 Query: 210 LPANRRFNDALADLHLLVDEIIAERRASGQKP--DDLLTALLEAKDDNGDPIGEQEIHDQ 267 + A + ++E+I R P + L +D G+ + + + Sbjct: 183 --KHWLGRHARNYEEIWIEELIDRVRDGKVNPPENTTLHKFSWYRDLEGNLLDTETAAVE 240 Query: 268 VVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNV 327 V+ IL P IA I ++ AL +PE ++++ +++ Sbjct: 241 VINILRPIV-AIAIFINFIALALHHYPEEKEKLKS----------------GDKKYSQMF 283 Query: 328 IVEAMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRW 387 + E R P + + GY+ G + Y DP+ + + F PDR+ Sbjct: 284 VQEVRRFYPFFPFVVALVKKDFTWKGYKFEEGTLTLLDLYGTNHDPEIWKNPDVFSPDRF 343 Query: 388 LPERAANVPKYAMKPFSAGK----RKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAV 443 + ++ P G +C + ++ + + L + +E + + Sbjct: 344 AKWEGS---PFSFIPQGGGDYFMGHRCAGEWVTIEVMKVSLDYLTNRMDYEV---PDQDL 397 Query: 444 RVGITLRP 451 + P Sbjct: 398 SFSMASMP 405 >5L1U-A nrPDB Length = 401 Score = 186 bits (471), Expect = 2e-47, Method: Composition-based stats. Identities = 65/409 (15%), Positives = 127/409 (31%), Gaps = 60/409 (14%) Query: 48 MSQLRDHGDVVRIKLGPKTVYAVTNPELTGALALNPDYHIAGPLWE----SLEGLLGKEG 103 M L+ G + R+ + + VT + L + ++ P + S Sbjct: 24 MLALQKEGPIARVGTAGEDAWLVTRYDEVRTLLADRRLRLSNPNPQPSAKSAARAFMVAL 83 Query: 104 VATAN----GPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDATSESF 159 A + H + R + P F + +E L ++ Sbjct: 84 AAGDDHETEPARHAQMRSLLIPRFSTRRLRLMKTRIEHHVDELLDQLAASAPPVDLHRVL 143 Query: 160 RVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDA 219 + C L G + +R ER F Sbjct: 144 SFRLPTMVVCDLLGVPLADR-ERFGQWARGTFDQSDNEHSANTF---------------- 186 Query: 220 LADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETI 279 + + E++A +R + DD+L+ L+ KD + + +I A+L G ET Sbjct: 187 -QQVVDYMLELVARKRV--EPGDDILSELIAEKDG---ALSDADIAHLGNAVLLFGYETT 240 Query: 280 ASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRL----R 335 I L +P ++ ++ + E +RL + Sbjct: 241 IVRIDLGTLLLLRNPVQRAQLAEDPGLAP-----------------AAVEEILRLGVGGK 283 Query: 336 PAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANV 395 + ++ R A + +G I G ++ + A D +++ D FD R V Sbjct: 284 GSNALIPRYAHGDITVGETVIRTGDAVMLAIGAANYDDRAFPDGGLFDLTR--------V 335 Query: 396 PKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVR 444 + F G R C + +LT + L + ++A +++R Sbjct: 336 RPRSHLAFGHGARHCIGRTLARIELTAVFERLFRRLPDLRLAVPEESLR 384 >4DO1-A nrPDB Length = 410 Score = 184 bits (468), Expect = 5e-47, Method: Composition-based stats. Identities = 79/442 (17%), Positives = 127/442 (28%), Gaps = 57/442 (12%) Query: 25 PVAGGGVPLLG---HGWRLARDPLAFMSQLRDHGDVVRIKLGPKTVYAVTNPELTGALAL 81 P +P L DP LRD G V + L VY V A+ Sbjct: 13 PPNDSTIPHLAIDPFSLDFFDDPYPDQQTLRDAGPV--VYLDKWNVYGVARYAEVHAVLN 70 Query: 82 NPDYHIAGP-----LWESLEGLLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIME 136 +P + ++ + + A+ P H R R + + Sbjct: 71 DPTTFCSSRGVGLSDFKKEKPWRPPSLILEADPPAHTRPRAVLSKVLSPATMKTIRDGFA 130 Query: 137 EEAHALTERWQPGKTVDATSESF-RVAVRVAARCLLRGQYMDERAERLCVALATVFRGMY 195 A A + +DA ++ + V + Q E + F Sbjct: 131 AAADAKVDELLQRGCIDAIADLAEAYPLSVFPDAMGLKQEGREHLLPYAGLVFNAFG--- 187 Query: 196 RRMVVPLGPLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDN 255 P + + A V+E R + A + A D Sbjct: 188 ------------PPNELRQTAIERSAPHQAYVNEQCQ--RPNLAPGG--FGACIHAFTDT 231 Query: 256 GDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAF 315 G+ I E V ++L+ G +T + I + LA P R+R + Sbjct: 232 GE-ITPDEAPLLVRSLLSAGLDTTVNGIGAAVYCLARFPGELQRLRSDPTL--------- 281 Query: 316 EDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKS 375 N EA+R V R E ELGG I G ++ + RDP+ Sbjct: 282 --------ARNAFEEAVRFESPVQTFFRTTTREVELGGAVIGEGEKVLMFLGSANRDPRR 333 Query: 376 YDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQ 435 + D +D R F +G C + + ++ +ALA K Sbjct: 334 WSDPDLYDITR---------KTSGHVGFGSGVHMCVGQLVARLEGEVMLSALARKVAAID 384 Query: 436 VAGSNDAVRVGITLRPHDLLVR 457 + G L V+ Sbjct: 385 IDGPVKRRFNNTLRGLESLPVK 406 >6BLD-A nrPDB Length = 419 Score = 184 bits (467), Expect = 7e-47, Method: Composition-based stats. Identities = 67/348 (19%), Positives = 112/348 (32%), Gaps = 39/348 (11%) Query: 102 EGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQ-PGKTVDATSESFR 160 + + P H + R+ + AF + ++ A + + + G VD Sbjct: 100 QSFLAMDPPRHTKLRKLVSAAFTPRQVRRIEDSIKINAKGIVDELRMAGGGVDFVEHC-A 158 Query: 161 VAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDAL 220 + + + G +R A +V P Y + Sbjct: 159 KELPIRTLSDMVGIPEADRERVAHAA---------DALVSWADPRYLNGREPLAVLFENQ 209 Query: 221 ADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIA 280 LH + + AERR + DDL +AL+ A+ D GD + + ++ V + G++T Sbjct: 210 MYLHQVAASLAAERR--DRPGDDLFSALVNAEVD-GDRLADADVAAFFVLLAVAGNDTTR 266 Query: 281 STIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWV 340 TI L+AL D P + + + G + E +R V Sbjct: 267 QTISHGLKALTDFPSQKAWLLADFDTRIG----------------TAVEELVRWATPVMT 310 Query: 341 LTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAM 400 R A A+ ELGG I AG ++ + D ++ D R Sbjct: 311 FRRTAAADFELGGQLIRAGEKVVMFYASGNWDEDAFCHPERLDLSRSPNPHVGFGGGGVH 370 Query: 401 KPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRVGIT 448 C H + AQL I L + + AG V Sbjct: 371 F--------CLGAHLARAQLRAIFGELLVQLP-DIQAGDPVYVPGNFV 409 >5HH3-A nrPDB Length = 397 Score = 183 bits (464), Expect = 1e-46, Method: Composition-based stats. Identities = 76/413 (18%), Positives = 140/413 (33%), Gaps = 61/413 (14%) Query: 43 DPLAFMSQLRDHGDVVRIKL----GPKTVYAVTNPELTGALALNPDYHIAGPLWESLEGL 98 DP+ + L G + + G +T + T + + + D A L+ Sbjct: 26 DPVPQLRSLMAEGPLTTLGTEESPGGRTAWLATGYDEIRQVL-SSDDFSARLLYGGTAAG 84 Query: 99 LGKEGVAT-ANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQP-GKTVDATS 156 + G T + P H R RR + PAF + + + P +E + + G VD Sbjct: 85 ITWPGFLTQYDPPEHTRLRRMVAPAFAVRRMQKFQPQVERVVQDSLDAIEALGGPVDFVP 144 Query: 157 ESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRF 216 F +V A C G D++A+ A+ + +R Sbjct: 145 -RFGWSVATTATCDFLGIPRDDQADLARSLHASRTE------------------RSGKRR 185 Query: 217 NDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGS 276 A ++++ A R DD+ ++ + GD I + E+ ++ G+ Sbjct: 186 TAAGNKFMTYMNKMTA--RTRRDPGDDMFGVVVR---EYGDEITDAELTGVAAFVMGAGA 240 Query: 277 ETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRP 336 + +A + +AD PE +R++ + V + E +R Sbjct: 241 DQVARFLAAGAWLMADDPEQFALLREKPDTVPDW-----------------LDEVIRYLT 283 Query: 337 AVWVL-TRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDN-LEFDPDRWLPERAAN 394 R A + +G + I AG + S A R +++ FD R PE Sbjct: 284 TDEKTHPRVATDDVRIGDHLIKAGDTVTCSLLAANR--RNFPRPEDRFDITRVRPE---- 337 Query: 395 VPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRVGI 447 F G C + ALA ++ ++A + +R+G Sbjct: 338 -----HLAFGHGIHHCLGRSLAELVFRTAIPALAHRFPTLRLAEPHREIRLGP 385 >1F4U-A nrPDB Length = 368 Score = 183 bits (463), Expect = 2e-46, Method: Composition-based stats. Identities = 64/427 (14%), Positives = 133/427 (31%), Gaps = 73/427 (17%) Query: 45 LAFMSQLRDHGDVVRIKLGPKTVYAVTNPELTGALA--LNPDYHIAGPLWESLEGLLGK- 101 + S++R V ++ V + T + + E LE L Sbjct: 2 YDWFSEMRKKDPVYY----DGNIWQVFSYRYTKEVLNNFSKFSSDLTGYHERLEDLRNGK 57 Query: 102 --------EGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVD 153 + T++ PLH R F + + E +L + P + D Sbjct: 58 IRFDIPTRYTMLTSDPPLHDELRSMSADIFSPQKLQTLETFIRETTRSLLDSIDPRE--D 115 Query: 154 ATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPAN 213 + V + + + G ++++ + F+ + +RL P Sbjct: 116 DIVKKLAVPLPIIVISKILGLPIEDKEK---------FKEWSDLVA------FRLGKPGE 160 Query: 214 RRFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILT 273 + +L E+I + ++++ ++ + + + E ++ +L Sbjct: 161 ------IFELGKKYLELIGYVKDHLNSGTEVVSRVVNS------NLSDIEKLGYIILLLI 208 Query: 274 PGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMR 333 G+ET + I + RIR+E I EA+R Sbjct: 209 AGNETTTNLISNSVIDFTRF-NLWQRIREE------------------NLYLKAIEEALR 249 Query: 334 LRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAA 393 P V R+ +LG I G + + RD + + D +F PDR Sbjct: 250 YSPPVMRTVRKTKERVKLGDQTIEEGEYVRVWIASANRDEEVFHDGEKFIPDR------- 302 Query: 394 NVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRVGITLRPHD 453 F +G C + + + + ++R ++ + V + Sbjct: 303 --NPNPHLSFGSGIHLCLGAPLARLEARIAIEEFSKRFRHIEIL-DTEKVPNEVLNGYKR 359 Query: 454 LLVRPVA 460 L+VR + Sbjct: 360 LVVRLKS 366 >2NZA-A nrPDB Length = 413 Score = 180 bits (457), Expect = 1e-45, Method: Composition-based stats. Identities = 85/448 (18%), Positives = 141/448 (31%), Gaps = 66/448 (14%) Query: 21 LREPPVAGGGVPLLGHGWRLARDPLAFMSQLRDHGDVVRIKLGPKT--VYAVTNPELTGA 78 + PP L G DP +++L G + R++L + T + A Sbjct: 10 GQSPPPVRDWPALDLDGPEF--DP--VLAELMREGPLTRVRLPHGEGWAWLATRYDDVKA 65 Query: 79 LALNPDY---HIAGPLWESLEGLL--GKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGP 133 + +P + + L +A A+ P H R RR + AF + A P Sbjct: 66 ITNDPRFGRAEVTQRQITRLAPHFKPRPGSLAFADQPDHNRLRRAVAGAFTVGATKRLRP 125 Query: 134 IMEEEAHALTER-WQPGKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFR 192 +E L + G D +A + G +R Sbjct: 126 RAQEILDGLVDGILAEGPPADLVERVLE-PFPIAVVSEVMGVPAADRER---------VH 175 Query: 193 GMYRRMVVPLGPLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAK 252 R+++ G A L+ + E + R +G + D+ + +L A Sbjct: 176 SWTRQIISTSG--------GAEAAERAKRGLYGWITETVRAR--AGSEGGDVYS-MLGAA 224 Query: 253 DDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRP 312 G+ +GE E + G E + + +L L E R+R+ A Sbjct: 225 VGRGE-VGETEAVGLAGPLQIGG-EAVTHNVGQMLYLLLTRRELMARMRERPGA------ 276 Query: 313 VAFEDVRKLRHTGNVIVEAMRLRP--AVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQ 370 G + E +R L R A+ + E+ G RI AG + S A Sbjct: 277 -----------RGTALDELLRWISHRTSVGLARIALEDVEVHGTRIAAGEPVYVSYLAAN 325 Query: 371 RDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATK 430 RDP + D D DR + G C + Q L+ L + Sbjct: 326 RDPDVFPDPDRIDLDR---------DPNPHLAYGNGHHFCTGAVLARMQTELLVDTLLER 376 Query: 431 YRFEQVAGSNDAV---RVGITLRPHDLL 455 ++A + V R + P L Sbjct: 377 LPGLRLAVPAEQVAWRRKTMIRGPRTLP 404 >6F0B-A nrPDB Length = 395 Score = 179 bits (454), Expect = 2e-45, Method: Composition-based stats. Identities = 67/381 (17%), Positives = 120/381 (31%), Gaps = 53/381 (13%) Query: 64 PKTVYAVTNPELTGALALNPDYHIA--GPLWESLEGLLGKEGVAT----ANGPLHRRQRR 117 + + E + + + P + L L + A + P HRR R Sbjct: 37 GTPAHVFSGYEDVRTVLQDRRFSSDSRRPNFTELTPTLQSQAAAPPFVRTDNPDHRRLRG 96 Query: 118 TIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDATSESFRVAVRVAARCLLRGQYMD 177 TI F I P + E + + E+F V V A L G + Sbjct: 97 TIAREFLPKHIELLRPAIREIVQGVLDGLAETAPPQDMLEAFAVPVASATVFRLLGIPAE 156 Query: 178 ERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALADLHLLVDEIIAERRAS 237 +RA L +G+ + + L + ++ + S Sbjct: 157 DRA-----LLTRCVKGVVSAVGS------------EDEGAEVFRTLGEYIGGLVQDP--S 197 Query: 238 GQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHA 297 D L+ L+ + E ++ ++ G +T ASTI L + A PE Sbjct: 198 ELPEDSLIRRLVTGPYQE-KQLTFHETIGVILMLIVGGYDTTASTISLSLVSYALQPEKF 256 Query: 298 DRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWV-LTRRAVAESELGGYRI 356 + + E + ++ E +R + L R A + E+GG + Sbjct: 257 SVVHEHPERIPL-----------------LVEELLRYHTVSQLGLGRIATEDVEVGGVTV 299 Query: 357 PAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFS 416 AG ++ + RD + + E D DR P F G +C + Sbjct: 300 RAGQMVVAALPLANRDESVFPNPDELDFDR---------PSVPHVGFGYGPHQCVGQALA 350 Query: 417 MAQLTLITAALATKYRFEQVA 437 +L A+ + ++A Sbjct: 351 RVELQEAIPAVIRRLPGMRLA 371 >4ZGX-A nrPDB Length = 489 Score = 179 bits (453), Expect = 3e-45, Method: Composition-based stats. Identities = 86/467 (18%), Positives = 153/467 (32%), Gaps = 26/467 (5%) Query: 10 TRAPAAPGAPELREPPVAGGGVPLLGHGWRLARDPLAFM-----SQLRDHGDVVRIKLGP 64 T+A AP E G L + ++ G + R LG Sbjct: 3 TKAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYNLGG 62 Query: 65 KTVYAVTNPELTGAL----ALNPDYHIAGPLWESLEGLLGKEGVATANGPLHRRQR-RTI 119 + V PE L +L+P I P + K GV NGP R R R Sbjct: 63 PRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLN 122 Query: 120 QPAFRLDAIPAYGPIMEEEAHALTERWQPGK--------TVDATSESFRVAVRVAARCLL 171 A+ + P+++ A ++ + T+D F + + L Sbjct: 123 PDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALF 182 Query: 172 R------GQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALADLHL 225 G + AL +F+ + M +P + + +A + Sbjct: 183 GERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQ 242 Query: 226 LVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMW 285 D I + + A+ + + I + + +T A ++ Sbjct: 243 YGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLM 302 Query: 286 LLQALADHPEHADRIRDEVEAVTGGRPV-AFEDVRKLRHTGNVIVEAMRLRPAVWVLTRR 344 L LA +P+ +R E A + +L + E +RL P L R Sbjct: 303 TLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERV 362 Query: 345 AVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFS 404 ++ L Y IPAG + Y++ R+ + ++P RWL R + + PF Sbjct: 363 VSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRN-FHHVPFG 421 Query: 405 AGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRVGITLRP 451 G R+C + A++ L+ + + E + + + LRP Sbjct: 422 FGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILRP 468 >6GII-A nrPDB Length = 479 Score = 179 bits (453), Expect = 3e-45, Method: Composition-based stats. Identities = 66/425 (15%), Positives = 131/425 (30%), Gaps = 55/425 (12%) Query: 40 LARDPLAFMSQLRDHGDVVRIKLGPKTVYAVTNPELTGALALNPDYHIAGPLWESL---- 95 DP F+ R+ + + VT + + +P + +S Sbjct: 76 YMADPAQFVRWAREQVPIF--YAPKLNYWVVTRYDTIKQIFRDPVTFSPSNVLQSFAQPS 133 Query: 96 ---EGLLGKEGVATA------NGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERW 146 +L + G A + P+H +RR + F + + + P++ E R+ Sbjct: 134 AEVRQVLERYGYAFNRTLVNEDEPMHLERRRVLMEPFASEHLAEHEPMVRELVRRAVNRF 193 Query: 147 QPGKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLY 206 D + V G D+R + M R + + Sbjct: 194 IDTGRADLVDQMI-WEVPFTVALHFLGVDDDDREK------------MRRFAIAHTVNAF 240 Query: 207 RLPLPANR-RFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIH 265 P P + + + E++ + R + P + + + + D + + +H Sbjct: 241 GRPSPEEQLAVAETVGQFWQFCGEVLEKMRRTADGPGWMRYS-IRQQKLYPDVVTDSYLH 299 Query: 266 DQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTG 325 + AI+ ET L+ L +H I + + Sbjct: 300 SMMQAIIVAAHETTVFATTNALKTLLEHETVWREICADPSLIP----------------- 342 Query: 326 NVIVEAMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPD 385 E +R V RR E E+ G R+P GA+I+ + D +DD FD Sbjct: 343 AAAEECLRYNGPVAGWRRRTTREVEVEGVRLPVGANILMVVASANHDSAHFDDPEFFDIG 402 Query: 386 RWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRV 445 R F G +C + ++ ++ L+ + ++A Sbjct: 403 R--------SNASEHLNFGYGAHQCLGRNLGRMEMQIMIEELSRRLPHMRLAEQRFDYLH 454 Query: 446 GITLR 450 ++ R Sbjct: 455 NVSFR 459 >6M7X-A nrPDB Length = 484 Score = 178 bits (451), Expect = 5e-45, Method: Composition-based stats. Identities = 80/436 (18%), Positives = 144/436 (33%), Gaps = 21/436 (4%) Query: 44 PLAFMSQLRDHGDVVRIKLGPKTVYAVTNPELTGAL----ALNPDYHIAGPLWESLEGLL 99 L ++ G + R LG + V PE L +L+P P + Sbjct: 42 HLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQHRG 101 Query: 100 GKEGVATANGPLHRRQR-RTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGK-------- 150 K GV NGP R R R +A+ + P+++ A ++ + Sbjct: 102 HKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSL 161 Query: 151 TVDATSESFRVAVRVAARCLLR------GQYMDERAERLCVALATVFRGMYRRMVVPLGP 204 T+D F + + L G + AL +F+ + M +P Sbjct: 162 TLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSL 221 Query: 205 LYRLPLPANRRFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEI 264 + +A + D I + + A+ + I Sbjct: 222 SRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAI 281 Query: 265 HDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPV-AFEDVRKLRH 323 + + +T ++ L LA +P +R E A + +L Sbjct: 282 KANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPL 341 Query: 324 TGNVIVEAMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFD 383 + E +RL P L R A ++ L Y IPAG + Y++ R+P + ++ Sbjct: 342 LRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYN 401 Query: 384 PDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAV 443 P RWL R + + PF G R+C + A++ L+ + + E + + + Sbjct: 402 PQRWLDIRGSGRN-FYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKM 460 Query: 444 RVGITLRPHDLLVRPV 459 LRP + Sbjct: 461 VYSFILRPSMFPLLTF 476 >5YHJ-A nrPDB Length = 413 Score = 177 bits (450), Expect = 7e-45, Method: Composition-based stats. Identities = 74/429 (17%), Positives = 145/429 (33%), Gaps = 46/429 (10%) Query: 34 LGHGWRLARDPLAFMSQLRD--HGDVVRIKLGPKTVYAVTNPELTGALALNPDYHI-AGP 90 L H R+ F++ R ++ +L + V + E + Sbjct: 11 LDHSVDFLREGYLFVANRRKSFQSNIFESRLLGERVICLGGEEAAEVFYDANKFTRQDAA 70 Query: 91 LWESLEGLLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGK 150 L+ L G+ GV T +G H +++ + I + E + + + Sbjct: 71 PKRLLKTLFGEGGVQTLDGSEHTHRKQMFMSLMTKENIDRLLRLTYREWNQIERMGEEIV 130 Query: 151 TVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPL 210 D E AV + L + + +R E + + + LGP Y Sbjct: 131 LYDIAQEVLMKAVCEWSGVPLAKEEVGKRTEEMRLLFESG---------TSLGPTYL--- 178 Query: 211 PANRRFNDALADLHLLVDEIIAERRASGQKPDDL--LTALLEAKDDNGDPIGEQEIHDQV 268 + A + + + +++ E R++ P++ L +D++G+ + E+ + +V Sbjct: 179 ----QGRKARSSAEVWIRQMVKEVRSNRLLPNEHTALYEFSWHRDESGELLPEEVVAVEV 234 Query: 269 VAILTPGSETIASTIM--WLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGN 326 + IL P T+A ++ + + AL P+ +++ E V+ Sbjct: 235 LNILRP---TVAISVYVLFTVLALHQFPDVKEQV--ERGEVSKTE--------------- 274 Query: 327 VIVEAMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDR 386 + E R P V R + E GY P G + Y D + + FDP R Sbjct: 275 FVQEVRRFYPFFPVAAARVKTDFEWDGYAFPEGTLTLLDLYGTNHDVSIWTEPDRFDPSR 334 Query: 387 W--LPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVR 444 + E N G +C +H ++A L + +Y + Sbjct: 335 FKDWKESPFNFIPQGGGDVDFG-HRCAGEHVTIAILAQVIELFTKEYAYTVPPQDLSYSF 393 Query: 445 VGITLRPHD 453 V + P Sbjct: 394 VDMPSLPKS 402 >2WIY-A nrPDB Length = 394 Score = 177 bits (448), Expect = 1e-44, Method: Composition-based stats. Identities = 82/424 (19%), Positives = 137/424 (32%), Gaps = 55/424 (12%) Query: 39 RLARDPLAFMSQLRDHGDVVRIKLGPKTVYAVTNPELTGALAL------NPDYHIAGPLW 92 +P + +L+ V +++ G Y V+ A P + AGP Sbjct: 17 EFRNNPYPWYRRLQQDHPVHKLEDG---TYLVSRYADVSHFAKLPIMSVEPGWADAGPWA 73 Query: 93 ESLEGLLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTV 152 + + LG ++ P H RR F + + E L + + G+ + Sbjct: 74 VASDTALG------SDPPHHTVLRRQTNKWFTPKLVDGWVRTTRELVGDLLDGVEAGQVI 127 Query: 153 DATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPA 212 +A + V V +L+ D+ + + + Sbjct: 128 EARRDLAVVPTHVTMARVLQ-LPEDDADAVMEAMFEAMLMQSAEPADGDVD--------- 177 Query: 213 NRRFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAIL 272 R A L V E++ ++R + D L +LL+A I E E ++ Sbjct: 178 --RAAVAFGYLSARVAEMLEDKRVN--PGDGLADSLLDAARAG--EITESEAIATILVFY 231 Query: 273 TPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAM 332 G I I ++ A PE R++ A +I E + Sbjct: 232 AVGHMAIGYLIASGIELFARRPEVFTAFRNDESA-----------------RAAIINEMV 274 Query: 333 RLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERA 392 R+ P R + E+GG I AG+ I + A RDP+ +DD FD R Sbjct: 275 RMDPPQLSFLRFPTEDVEIGGVLIEAGSPIRFMIGAANRDPEVFDDPDVFDHTR------ 328 Query: 393 ANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRVGITLRPH 452 F G C S A+ T + A LA +Y ++A R Sbjct: 329 -PPAASRNLSFGLGPHSCAGQIISRAEATTVFAVLAERYERIELAEEPTVAHNDFARRYR 387 Query: 453 DLLV 456 L + Sbjct: 388 KLPI 391 >3WEC-A nrPDB Length = 419 Score = 174 bits (441), Expect = 7e-44, Method: Composition-based stats. Identities = 74/435 (17%), Positives = 134/435 (30%), Gaps = 65/435 (14%) Query: 39 RLARDPLAFMSQLRDHGDVVRIKLGPKTVYAVTNPELTGALALN---PDYHIAGPLWESL 95 DP ++LR + R LG + V + + + ++ L Sbjct: 21 TFKADPYPVYARLRTELPIHRSALG---AWIVADYTSCDKVLRSRLFGKDFANSTFFDHL 77 Query: 96 EGLLGKEG--------------VATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHA 141 ++G++ + P H R R + AF + I+ A + Sbjct: 78 TSMMGEDMPPFLGLGIDGDARPFMLTDPPEHTRLRGLVSDAFTRSTTTSMDDIVLSAASS 137 Query: 142 LTERWQPGKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVP 201 + DA SE V + G +R F + Sbjct: 138 AVRHLE--HCTDAVSEVAE-PFPVEVLSSILGIPDKDRGR---------FSEWSNLVAGV 185 Query: 202 LGPLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGE 261 L + +P R + A+ + + SG P+ L+ L E GD + Sbjct: 186 LDINFAIPKEVADRRSAAIEESIDYFRTLA----TSGNAPEGLVRRLSEVSH-GGDQLSV 240 Query: 262 QEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKL 321 EI + I G ET ++TI +L + H + +++R + Sbjct: 241 DEIAATCLLITVAGQETTSNTIGNMLITFSRHADQFEQVRANPQ---------------- 284 Query: 322 RHTGNVIVEAMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLE 381 N + E +R P R A+ + E+ G I G ++ + R ++ + Sbjct: 285 -FIENAVAEVLRFEPPAHEAGRIALEDCEVSGANITKGDAVMVLLASGNR--EAVERGDT 341 Query: 382 FDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSND 441 F R P + + G C + + L L+ +YR +VA + Sbjct: 342 FSVTR---------PDVSSLSYGRGIHHCLGSALANSMLQHFLRELSQRYRSIEVAEPIN 392 Query: 442 AVRVGITLRPHDLLV 456 P L V Sbjct: 393 YKPGMGLRGPETLSV 407 >5H1Z-A nrPDB Length = 407 Score = 174 bits (441), Expect = 7e-44, Method: Composition-based stats. Identities = 61/416 (14%), Positives = 130/416 (31%), Gaps = 48/416 (11%) Query: 48 MSQLRDHGDVVRIKLGPK-TVYAVTNP------ELTGALALNPDYHIAGPLWESLEGLLG 100 +LR V R++ ++V++ E L + E+ + Sbjct: 28 FRELRATAPVHRVEHSDFGPYWSVSSYKPIITVESLPDLYSSAGGITLADFIENNPTDVR 87 Query: 101 KEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDATSESFR 160 + P H QRRT+ PAF + + + + + D Sbjct: 88 MPMFIAMDRPKHTGQRRTVAPAFTPSEMVRMSDNIRMRTAEVLDSLEWNTPFDWVDTV-S 146 Query: 161 VAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDAL 220 V + +L +ER + + + + L R + Sbjct: 147 VELTTQMLAILFDFPWEERRKL----------TFWSDWAGDIELVKNEELRLER--LRHM 194 Query: 221 ADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIA 280 + + + P DL++ ++ + D + + E ++ ++ G++T Sbjct: 195 YECGGYFQNLWNAKIGKPPTP-DLISMMIHS--DAMAEMDQMEFLGNLILLIVGGNDTTR 251 Query: 281 STIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWV 340 +T+ + L P+ ++ + + N + E +R + + Sbjct: 252 NTMSAVAYGLDLFPDQRAKLEADPSMIP-----------------NTVQEIIRWQTPLAH 294 Query: 341 LTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAM 400 + R A +SEL G +I AG + + RD +++ DR R Sbjct: 295 MRRTATVDSELEGQQIKAGDKLALWYISANRDESVFENADRIIVDRPNARR--------H 346 Query: 401 KPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRVGITLRPHDLLV 456 F G +C + Q+ ++ +A + V G + V L V Sbjct: 347 LAFGHGIHRCVGARLAELQIAVLLEEMAKRRMRVNVLGEPERVAACFVHGYRKLPV 402 >5EX8-A nrPDB Length = 424 Score = 171 bits (434), Expect = 5e-43, Method: Composition-based stats. Identities = 75/400 (18%), Positives = 130/400 (32%), Gaps = 59/400 (14%) Query: 64 PKTVYAVTNPELTGALALNPDYHIAGPLWESLEGLLGKEGVAT-ANGPLHRRQRRTIQPA 122 +T + T + + + D A L+ + G T + P H R RR + PA Sbjct: 78 GRTAWLATGIDEVRQVLGS-DKFSARLLYGGTAAGITWPGFLTQYDPPEHTRLRRMVVPA 136 Query: 123 FRLDAIPAYGPIMEEEAHALTERWQP-GKTVDATSESFRVAVRVAARCLLRGQYMDERAE 181 F + + P +E+ + + G VD F A+ A C G D++A+ Sbjct: 137 FSHRRMQKFRPRVEQIVQDSLDTIESLGGPVDFVP-HFGWAIATPATCDFLGIPRDDQAD 195 Query: 182 RLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQKP 241 + LA+ +++R A + + +A+ R Sbjct: 196 LARILLASRTD------------------RSDKRRTAAGNKFMTYMKQHVAQSRRGS--G 235 Query: 242 DDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIR 301 DDL + +NGD I + E+ ++ ++ +A + + + P +R Sbjct: 236 DDLFGIVGR---ENGDAITDAELTGVAAFVMGAAADQVARLLAAGAWLMVEQPAQFALLR 292 Query: 302 DEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVL-TRRAVAESELGGYRIPAGA 360 ++ E V + E MR R A + +G + AG Sbjct: 293 EKPETVPEW-----------------LDETMRYLTTDEKTHPRVATQDVRIGNQLVKAGD 335 Query: 361 DIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQL 420 + S A R P EFD R K F G C + Sbjct: 336 TVTCSLLAANR-PNYPSAEDEFDITR---------EKAEHLAFGHGIHHCLGRAMAELMF 385 Query: 421 TLITAALATKYRFEQVAGSNDAVRVGITLRPHDLLVRPVA 460 + ALA ++ ++A ITL P V + Sbjct: 386 KVSIPALAHRFPTLRLADPQRE----ITLGPPPFDVEALL 421 >2X9P-A nrPDB Length = 404 Score = 171 bits (432), Expect = 7e-43, Method: Composition-based stats. Identities = 71/412 (17%), Positives = 129/412 (31%), Gaps = 63/412 (15%) Query: 46 AFMSQLRDHGDVVRIKLG-PKTVYAVTNPELTGALALNPDYHIAGPLWESLEGLLGKE-- 102 + L+D G + R++ + VT L + P S + Sbjct: 30 PLLRALQDRGPIHRVRTPAGDEAWLVTRHAELKQLLHDERIGRTHPDPPSAAQYVRSPFL 89 Query: 103 --GVATANGP----LHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDATS 156 ++ A+ H RR + P F + P +EE A L + + Sbjct: 90 DLLISDADAESGRRQHAETRRLLTPLFSARRVLEMQPKVEEAADTLLDAFIAQGPPGDLH 149 Query: 157 ESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRF 216 V + C + G RAE L T+ G+ + L Sbjct: 150 GELTVPFALTVLCEVIGVPPQRRAE-----LTTLLAGIAK-------------LDDREGA 191 Query: 217 NDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGS 276 A DL V ++ +RA + D+++ L N + E + + +L G Sbjct: 192 VRAQDDLFGYVAGLVEHKRA--EPGPDIISRL------NDGELTEDRVAHLAMGLLFAGL 243 Query: 277 ETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRP 336 +++AS + + LA HP+ + + + E +R Sbjct: 244 DSVASIMDNGVVLLAAHPDQRAAALADPD-----------------VMARAVEEVLRTAR 286 Query: 337 AVWVL--TRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAAN 394 A + R A + E GG I AG +++ D +++ EFD R Sbjct: 287 AGGSVLPPRYASEDMEFGGVTIRAGDLVLFDLGLPNFDERAFTGPEEFDAAR-------- 338 Query: 395 VPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRVG 446 F G C + +L + L T+ + + +R+ Sbjct: 339 -TPNPHLTFGHGIWHCIGAPLARLELRTMFTKLFTRLPELRPELPVEQLRLK 389 >5HDI-A nrPDB Length = 404 Score = 169 bits (429), Expect = 2e-42, Method: Composition-based stats. Identities = 74/410 (18%), Positives = 125/410 (30%), Gaps = 60/410 (14%) Query: 36 HGWRLARDPLAFMSQLRDHGDVVRIKLGPKTVYAVTNPELTGALALNPDYHI-------- 87 G +DP ++R G V RI YAV + P+ Sbjct: 11 FGAESVQDPYPLYERMRAAGSVHRI--ANSDFYAVCGWDAVNEAIGRPEDFSSNLTATMT 68 Query: 88 ----AGPLWESLEGLLG-KEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHAL 142 ++ L G +ATA+ P H R+ + I + A L Sbjct: 69 YTAEGTAKPFEMDPLGGPTHVLATADDPAHAVHRKLVLRHLAAKRIRVMEQFTVQAADRL 128 Query: 143 -TERWQPGKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVP 201 + Q G + + R+ + V A + + + A + G+ + Sbjct: 129 WVDGMQDGCIEWMGAMANRLPMMVVAELIGLPDPDIAQLVKWGYAATQLLEGLVENDQLV 188 Query: 202 LGPLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEA-KDDNGDPIG 260 + AL +L + E RA+ D+LL L A D + Sbjct: 189 AAGV-------------ALMELSGYIFEQFD--RAAADPRDNLLGELATACASGELDTLT 233 Query: 261 EQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRK 320 Q +V + G E+ A+ + + LA P+ ++R E Sbjct: 234 AQ---VMMVTLFAAGGESTAALLGSAVWILATRPDIQQQVRANPEL-------------- 276 Query: 321 LRHTGNVIVEAMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNL 380 G I E +R P R + L G +PA + ++ A RDP ++ Sbjct: 277 ---LGAFIEETLRYEPPFRGHYRHVRNATTLDGTELPADSHLLLLWGAANRDPAQFEAPG 333 Query: 381 EFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATK 430 EF DR F G C + + ++ L + Sbjct: 334 EFRLDR--------AGGKGHISFGKGAHFCVGAALARLEARIVLRLLLDR 375 >2RFC-A nrPDB Length = 343 Score = 168 bits (425), Expect = 5e-42, Method: Composition-based stats. Identities = 58/395 (14%), Positives = 120/395 (30%), Gaps = 65/395 (16%) Query: 65 KTVYAVTNPELTGALALNPDYHIAGPLWESLEGLLGKEGVATANGPLHRRQRRTIQPAFR 124 + V + +N + P G T + P H+ R P F Sbjct: 10 DGAWHVYKYSDVKHVLMNDKIFSSNPGNRYSNA--GGISFITMDNPEHKEFRDISAPYFL 67 Query: 125 LDAIPAYGPIMEEEAHALTERWQPGKTVDATSESFRVAVRVAARCLLRGQYMDERAERLC 184 I Y +EE ++ L + D SE + V + V + G + Sbjct: 68 PSKINDYKDFIEETSNDLIKNIDNK---DIISE-YAVRLPVNIISKILGIPDSD------ 117 Query: 185 VALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQKPDDL 244 +PL L+ + N+R + V+ + R K D Sbjct: 118 ---------------MPLFKLWSDYIIGNKR-----DENFNYVNNRMVSRLLEIFKSDSH 157 Query: 245 -LTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDE 303 + +L + E ++ ++ G+ET + I +++ + ++P+ D Sbjct: 158 GIINVLAGSSLKNRKLTMDEKIKYIMLLIIGGNETTTNLIGNMIRVIDENPDIID----- 212 Query: 304 VEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLT-RRAVAESELGGYRIPAGADI 362 L++ + E +R + L R A +S + +I G + Sbjct: 213 ---------------DALKNRSGFVEETLRYYSPIQFLPHRFAAEDSYINNKKIKKGDQV 257 Query: 363 IYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTL 422 I + RD +D+ F R + F G C + + ++ Sbjct: 258 IVYLGSANRDETFFDEPDLFKIGR----------REMHLAFGIGIHMCLGAPLARLEASI 307 Query: 423 ITAALATKYRFEQVAGSNDAVRVG-ITLRPHDLLV 456 + ++ ++ + + L L + Sbjct: 308 ALNDILNHFKRIKIDYKKSRLLDNKMVLGYDKLFL 342 >1UE8-A nrPDB Length = 367 Score = 168 bits (425), Expect = 5e-42, Method: Composition-based stats. Identities = 61/425 (14%), Positives = 126/425 (29%), Gaps = 73/425 (17%) Query: 45 LAFMSQLRDHGDVVRIKLGPKTVYAVTNPELTGALALNPDYHIAG--------PLWESLE 96 + Q+R V V+ + E + + + + S + Sbjct: 2 YDWFKQMRKESPVYY----DGKVWNLFKYEDCKMVLNDHKRFSSNLTGYNDKLEMLRSGK 57 Query: 97 GLLG---KEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVD 153 + + T++ PLH R AF +P + E L + D Sbjct: 58 VFFDIPTRYTMLTSDPPLHDELRNLTADAFNPSNLP--VDFVREVTVKLLSEL--DEEFD 113 Query: 154 ATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPAN 213 ESF + + + + G D + + L + G + Sbjct: 114 VI-ESFAIPLPILVISKMLGINPDVKKVKDWSDLVALRLGRADEIFS------------- 159 Query: 214 RRFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILT 273 +L + + R+ G++ DL + + + E E + ++ Sbjct: 160 --IGRKYLELISFSKKELDSRK--GKEIVDLTGKIANS------NLSELEKEGYFILLMI 209 Query: 274 PGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMR 333 G+ET + I ++ + D +R++ + EA+R Sbjct: 210 AGNETTTNLIGNAIEDFTLY-NSWDYVREKGAL-------------------KAVEEALR 249 Query: 334 LRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAA 393 P V R + ++ I G + + RD + + D F PDR Sbjct: 250 FSPPVMRTIRVTKEKVKIRDQVIDEGELVRVWIASANRDEEVFKDPDSFIPDR------- 302 Query: 394 NVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRVGITLRPHD 453 F +G C + + + A K+R +++ + + + Sbjct: 303 --TPNPHLSFGSGIHLCLGAPLARLEARIALEEFAKKFRVKEIVK-KEKIDNEVLNGYRK 359 Query: 454 LLVRP 458 L+VR Sbjct: 360 LVVRV 364 >3BUJ-A nrPDB Length = 397 Score = 166 bits (421), Expect = 1e-41, Method: Composition-based stats. Identities = 84/386 (21%), Positives = 132/386 (34%), Gaps = 52/386 (13%) Query: 41 ARDPLAFMSQLRDHGDVVRIKLGPKTVYAVTNPELTGALALNPDYHIA--GPLWESLEGL 98 RDP L H V R G V+ V+ A+ + + W L G Sbjct: 12 RRDPYPSYHWLLRHDPVHR---GAHRVWYVSRFADVRAVLGDERFARTGIRRFWTDLVGP 68 Query: 99 -----LGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVD 153 + + + + P H R R + PAF A+ P++ L +D Sbjct: 69 GLLAEIVGDIILFQDEPDHGRLRGVVGPAFSPSALRRLEPVIAGTVDDLLRPALARGAMD 128 Query: 154 ATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPAN 213 E + + A L G + + R Sbjct: 129 VVDEL-AYPLALRAVLGLLGLPAAD--WGAVGRWSRDVGRTLDRGAS---------AEDM 176 Query: 214 RRFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILT 273 RR + A+A+ V+ +A RR G +DLL +L+A D + EI VV + Sbjct: 177 RRGHAAIAEFADYVERALARRRREG--GEDLLALMLDAHDRG--LMSRNEIVSTVVTFIF 232 Query: 274 PGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMR 333 G ET+AS + + +L HP+ D +R + + E +R Sbjct: 233 TGHETVASQVGNAVLSLLAHPDQLDLLRRRPDL-----------------LAQAVEECLR 275 Query: 334 LRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAA 393 P+V TR+ + EL G R+ ++ A RDP+ YD +FD +R Sbjct: 276 YDPSVQSNTRQLDVDVELRGRRLRRDDVVVVLAGAANRDPRRYDRPDDFDIER------- 328 Query: 394 NVPKYAMKPFSAGKRKCPSDHFSMAQ 419 F AG R C + + Q Sbjct: 329 --DPVPSMSFGAGMRYCLGSYLARTQ 352 >6G5O-A nrPDB Length = 399 Score = 154 bits (389), Expect = 7e-38, Method: Composition-based stats. Identities = 69/408 (16%), Positives = 139/408 (34%), Gaps = 57/408 (13%) Query: 43 DPLAFMSQLRDHGDVVRIKLGPKTVYAVTNPELTGALALNPDYHIAGPL-----WESLEG 97 DP + + +G++ V + + A N +G + S Sbjct: 8 DPFEKARESKGYGEM---NDQDDPVTMLLRHKDVRKSAHNYKTFQSGAVPGRIVIPSEVD 64 Query: 98 LLGKEGVAT-ANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDATS 156 + + + P+H R ++P F+ Y + + + E +V+ + Sbjct: 65 IRDTRQIPFEVDPPVHGVYRAIVEPWFKRPLQAEYQEKLTAQISEIVEETLLKGSVEVVT 124 Query: 157 ESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRF 216 + F + ++ A LL E +E VFR + Sbjct: 125 D-FALRLQSRALTLLLNTPFSE-SETWISWGTHVFRSEGEALD----------------- 165 Query: 217 NDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGS 276 D L+ +DE I RAS DD+ + LL ++ + G + ++E+ +V G Sbjct: 166 GDKANILYHYIDEQID--RASENPGDDMYSVLLNSEFE-GRKLTKEEVKGVMVLTFAGGR 222 Query: 277 ETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRP 336 +T+ + + + LA+HPE +R+R E E TG + E +R Sbjct: 223 DTVINAVTNSIAYLAEHPEALERLRKEPEI-----------------TGRAVEEMIRYFS 265 Query: 337 AVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVP 396 + + R ++ + + + A + I + RD +++ E DR + Sbjct: 266 PLTQMGRVVTEDTHVCEHAVKADSRISLCWASANRDAAVFENPNEIVLDRKVNP------ 319 Query: 397 KYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVR 444 F C + L ++ LA K ++ + + Sbjct: 320 ---HVGFGFSHHNCLGATHARQILKILLQTLAQKVASFEILDYKENIE 364 >5LIV-A nrPDB Length = 450 Score = 153 bits (387), Expect = 1e-37, Method: Composition-based stats. Identities = 72/409 (17%), Positives = 123/409 (30%), Gaps = 52/409 (12%) Query: 42 RDPLAFMSQLR---DHGDVVRIKLGPKTVYAVTNPELTGALALNPDYHIAGPLWESLEGL 98 D AF +LR +V + L + A + Sbjct: 64 EDATAFGRRLRAAAQQAPIVFDTAFGMPIL------LRKSHITTAYRDTATFSTRMFQAG 117 Query: 99 LGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEE-EAHALTERWQPGKTVDATSE 157 + G+A G H R RR F A+ Y + + +R VD + Sbjct: 118 ILNGGLAAMQGDEHARMRRVYNMFFLPRAVSQYEERFVRPISEQVVDRLAGKPRVDLLED 177 Query: 158 SFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPAN-RRF 216 F + + L G ++ E R+ L L R+ PA Sbjct: 178 -FAMELPRRVIGELFGFPAEKLHE------------TDERVRAMLRGLVRMHDPAAVAES 224 Query: 217 NDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGS 276 A + L+ E++ R S D LL +L + V++++ G Sbjct: 225 QRAYGETLGLITEVVE--RESRDTSDTLLGEILRTLKAEHMD-TIEASRQIVLSLILGGY 281 Query: 277 ETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRP 336 ET + + + AL HP+ R+R + + I E MR P Sbjct: 282 ETTSWLVANTIHALLAHPDTLARVRQDPSLLP-----------------AAIEEGMRWCP 324 Query: 337 AVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVP 396 + + + R + L + AG + + A D +Y +D DR P Sbjct: 325 SSFGVLRMVERDVRLDDQALSAGTVVCLAGIAGNYDETAYPSPEVYDIDR--------KP 376 Query: 397 KYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRV 445 A F G C + + + AL ++ + + Sbjct: 377 LPAANVFGGGAHFCVGAPLARMEARVGLQALLARFPGLRAVPEERPSFM 425 >6F88-A nrPDB Length = 400 Score = 153 bits (386), Expect = 2e-37, Method: Composition-based stats. Identities = 72/409 (17%), Positives = 123/409 (30%), Gaps = 52/409 (12%) Query: 42 RDPLAFMSQLR---DHGDVVRIKLGPKTVYAVTNPELTGALALNPDYHIAGPLWESLEGL 98 D AF +LR +V + L + A + Sbjct: 14 EDATAFGRRLRAAAQQAPIVFDTAFGMPIL------LRKSHITTAYRDTATFSTRMFQAG 67 Query: 99 LGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEE-EAHALTERWQPGKTVDATSE 157 + G+A G H R RR F A+ Y + + +R VD + Sbjct: 68 ILNGGLAAMQGDEHARMRRVYNMFFLPRAVSQYEERFVRPISEQVVDRLAGKPRVDLLED 127 Query: 158 SFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPAN-RRF 216 F + + L G ++ E R+ L L R+ PA Sbjct: 128 -FAMELPRRVIGELFGFPAEKLHE------------TDERVRAMLRGLVRMHDPAAVAES 174 Query: 217 NDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGS 276 A + L+ E++ R S D LL +L + V++++ G Sbjct: 175 QRAYGETLGLITEVVE--RESRDTSDTLLGEILRTLKAEHMD-TIEASRQIVLSLILGGY 231 Query: 277 ETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRP 336 ET + + + AL HP+ R+R + + I E MR P Sbjct: 232 ETTSWLVANTIHALLAHPDTLARVRQDPSLLP-----------------AAIEEGMRWCP 274 Query: 337 AVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVP 396 + + + R + L + AG + + A D +Y +D DR P Sbjct: 275 SNFGVLRMVERDVRLDDQALSAGTVVCLAGIAGNYDETAYPSPEVYDIDR--------KP 326 Query: 397 KYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRV 445 A F G C + + + AL ++ + + Sbjct: 327 LPAANVFGGGAHFCVGAPLARMEARVGLQALLARFPGLRAVPEERPSFM 375 >5OMS-A nrPDB Length = 409 Score = 151 bits (380), Expect = 8e-37, Method: Composition-based stats. Identities = 68/414 (16%), Positives = 134/414 (32%), Gaps = 41/414 (9%) Query: 19 PELREPPVAGGGVPLLGHGWRLARDPLAFMSQLRDHGDVVRIKLGPKTVYAVTNPELTGA 78 P + + +L R+P +LR + + + Y + E+ Sbjct: 2 PMTTTERPDLAWLDEV-TMTQLERNPYEVYERLRAEAPLAFVPVLG--SYVASTAEVCRE 58 Query: 79 LALNPDYHIAGPLWESLEGLLGKEGVATANGPLHRRQRRTIQPAFRLDAIPA-YGPIMEE 137 +A +PD+ + + G + NG +H R ++PA + + ++ Sbjct: 59 VATSPDFEAV--ITPAGGRTFGHPAIIGVNGDIHADLRSMVEPALQPAEVDRWIDDLVRP 116 Query: 138 EAHALTERWQPGKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRR 197 A ER++ + ++ + V V + L G + +L A + R Sbjct: 117 IARRYLERFENDGHAELVAQ-YCEPVSVRSLGDLLGLQEVDSD-KLREWFAKLNRSFTNA 174 Query: 198 MVVPLGPLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQKPDD-LLTALLEAKDDNG 256 V G + A A++ +VD +I + + PDD ++ L G Sbjct: 175 AVDENGEFAN--PEGFAEGDQAKAEIRAVVDPLIDK---WIEHPDDSAISHWLHDGMPPG 229 Query: 257 DPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFE 316 + I+ + L + + L L PE + + D+ + Sbjct: 230 QTRDREYIYPTIYVYLLGAMQEPGHGMASTLVGLFSRPEQLEEVVDDPTLIP-------- 281 Query: 317 DVRKLRHTGNVIVEAMRLRPAVWV-LTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKS 375 I E +R +W R + + G +PAG ++ S + D Sbjct: 282 ---------RAIAEGLRWTSPIWSATARISTKPVTIAGVDLPAGTPVMLSYGSANHDTGK 332 Query: 376 YDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALAT 429 Y+ ++D R P F AG C +F+ + + L Sbjct: 333 YEAPSQYDLHR---------PPLPHLAFGAGNHACAGIYFANHVMRIALEELFE 377 >6G71-A nrPDB Length = 405 Score = 149 bits (375), Expect = 3e-36, Method: Composition-based stats. Identities = 71/419 (16%), Positives = 138/419 (32%), Gaps = 53/419 (12%) Query: 21 LREPPVAGGGVPLLGHGWRLARDPLAFMSQLRDHGDVVRIKLGPKTVYAVTNPELTGALA 80 L E P A H L ++P +LR V + + Y +T+ A Sbjct: 5 LLEAPTADWV-----HLADLYQNPFPIFERLRSESPVAWVPEAGR--YLITSYSGVLAAD 57 Query: 81 LNPDYHIAGPLWESLEGLLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAY-GPIMEEEA 139 ++ A + +G + + P H+ +RR QP+ + + E A Sbjct: 58 VDQTTFSANEKKSLMLRAMGH-SMLRKDDPDHQVERRAWQPSLKPGTVKKVWKQKFAENA 116 Query: 140 HALTER-WQPGKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRM 198 + G D V R L+ + E + + + Sbjct: 117 DRYLDAYIDAGSGSDFMQGFAAPFVAENLRALIGFENASEADLQR-----------WSQT 165 Query: 199 VVPLGPLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDP 258 ++ Y + + ++ ++E+I SG+ D LL+ LL + D Sbjct: 166 LIDGAGNYPDDPDVWAKAKQSSDEIDAALEEMIQWH--SGRPGDSLLSYLLRSADY---Q 220 Query: 259 IGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDV 318 + + I + + G + AL + + + + + Sbjct: 221 MPLESIRSNIKMTIGGGLNEPRDVLGVSTLALLSSSKQLELVLRDPKLW----------- 269 Query: 319 RKLRHTGNVIVEAMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDD 378 G V E++R + ++ R+ V ++EL GY IP GA + + RD + D Sbjct: 270 ------GAVFEESIRWVAPIGMVPRQTVVDTELDGYFIPRGAKLGLCILSANRDRSVWSD 323 Query: 379 NLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLI-TAALATKYRFEQV 436 FD +R A F G C + +Q+ + AL ++ + ++ Sbjct: 324 PDRFDIER---------GSEAHLAFGKGVHVCLGAWAARSQVADVGLPALFSRLKGLRL 373 >5HIW-A nrPDB Length = 398 Score = 149 bits (375), Expect = 3e-36, Method: Composition-based stats. Identities = 76/415 (18%), Positives = 135/415 (32%), Gaps = 62/415 (14%) Query: 42 RDPLAF---MSQLRDHGDVVRIKLGPKTVYAVTNPELTGALALNPDYHIAGPLWESLEGL 98 +DP AF ++ V + V + ++ A+ + + + + Sbjct: 13 KDPSAFGIHLAAAAREHSVYFDEGLGVPV-VLRGADVV-AVLRDSETFSTR----TYDTG 66 Query: 99 LGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPI-MEEEAHALTERWQPGKTVDATSE 157 + K + T G H R RR I Y + A + ER + + + Sbjct: 67 IMKGALVTLGGEAHTRMRRLFNAVLSPRVISRYEEATVTPVARRVVERLVRKERAELFDD 126 Query: 158 SFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFN 217 F +++ + L G E + R M R +V+P P+ Sbjct: 127 -FAISMPMGVTSALFGLP-----EERIAENDALIRKMIRSVVMPQDPVVV------AEGR 174 Query: 218 DALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIH-DQVVAILTPGS 276 A A + + EI R D LL + A G +G E V+ ++ Sbjct: 175 SAHAAMEAQLREIAE--REVAHPSDTLLGEIARAIVAEG--LGGVEACEGVVLTLILGSY 230 Query: 277 ETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRP 336 ET + + LL AL HP+ +++R + + I E+ R Sbjct: 231 ETTSWMLANLLVALLAHPDAMNQLRQQPSLLP-----------------QAIEESTRWCS 273 Query: 337 AVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVP 396 + + R E+ +GG + AG + S A D + Y FD R Sbjct: 274 SAAGIVRFVEREATIGGETLAAGTILYLSLIARHYDEEIYPRPETFDIHR---------R 324 Query: 397 KYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRVGITLRP 451 M F G C + + + + L ++ A+R T++P Sbjct: 325 PVGMLNFGGGLHYCVGAPLARMEARVGVSLLLERFP---------ALRADPTVQP 370 >3OFT-A nrPDB Length = 396 Score = 146 bits (369), Expect = 1e-35, Method: Composition-based stats. Identities = 66/378 (17%), Positives = 119/378 (31%), Gaps = 56/378 (14%) Query: 55 GDVVRIKLGPKTVYAVTNPELTGALALNPDYHIAGPLWESLEGLLGKEGVAT----ANGP 110 G V G + ++ L D ++ LGK + +G Sbjct: 38 GLVWSTANGGH--WIAARGDVVRELW--GDAERLSSQCLAVTPGLGK-VMQFIPLQQDGA 92 Query: 111 LHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDATSESFRVAVRVAARCL 170 H+ R + + A P ++ A L E +P + D S+ + + + Sbjct: 93 EHKAFRTPVMKGLASRFVVALEPKVQAVARKLMESLRPRGSCDFVSDFAEI-LPLNIFLT 151 Query: 171 LRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALADLHLLVDEI 230 L +++R R + ++ P G + + Sbjct: 152 LIDVPLEDRPR---------LRQLGVQLTRPDGSM---------TVEQLKQAADDYLWPF 193 Query: 231 IAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQAL 290 I +R A Q DDL + +L ++ G P E +L G +T+A+ I + L Sbjct: 194 IEKRMA--QPGDDLFSRIL-SEPVGGRPWTVDEARRMCRNLLFGGLDTVAAMIGMVALHL 250 Query: 291 ADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESE 350 A HPE +R+ + + E MR P V ++R AVA+ + Sbjct: 251 ARHPEDQRLLRERPDLIP-----------------AAADELMRRYPTV-AVSRNAVADVD 292 Query: 351 LGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKC 410 G I G + DP S++ E DR + G +C Sbjct: 293 ADGVTIRKGDLVYLPSVLHNLDPASFEAPEEVRFDR-------GLAPIRHTTMGVGAHRC 345 Query: 411 PSDHFSMAQLTLITAALA 428 + ++ + Sbjct: 346 VGAGLARMEVIVFLREWL 363 >4FB2-A nrPDB Length = 398 Score = 145 bits (365), Expect = 5e-35, Method: Composition-based stats. Identities = 60/394 (15%), Positives = 121/394 (30%), Gaps = 56/394 (14%) Query: 44 PLAFMSQLRDHG---DVVRIKLGPKTVYAVTNPELTGALALNPDYHIAGPL-WESLEGLL 99 P AF LRD + + + V + A+ N + + E Sbjct: 21 PHAFFEALRDEAETTPIGWSEAYG-GHWVVAGYKEIQAVIQNTKAFSNKGVTFPRYETGE 79 Query: 100 GKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTE-RWQPGKTVDATSES 158 + +A + P+H++ R+ + F +A + + + + L + R + G+ AT + Sbjct: 80 FELMMAGQDDPVHKKYRQLVAKPFSPEATDLFTEQLRQSTNDLIDARIELGEGDAATWLA 139 Query: 159 FRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFND 218 + R+ A L + R + + Sbjct: 140 NEIPARLTAILLGLPPEDGDTYRRWV--------------------WAITHVENPEEGAE 179 Query: 219 ALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSET 278 A+L +IAERR + +D+++ ++ +K D G+ + E ++ +L G + Sbjct: 180 IFAELVAHARTLIAERRTN--PGNDIMSRVIMSKID-GESLSEDDLIGFFTILLLGGIDN 236 Query: 279 IASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAV 338 A + + LA E R+ E + N + E +R Sbjct: 237 TARFLSSVFWRLAWDIELRRRLIAHPELIP-----------------NAVDELLRFYGPA 279 Query: 339 WVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKY 398 V R E +G + G + RD ++D +R Sbjct: 280 MVG-RLVTQEVTVGDITMKPGQTAMLWFPIASRDRSAFDSPDNIVIER---------TPN 329 Query: 399 AMKPFSAGKRKCPSDHFSMAQLTLITAALATKYR 432 G +C H + + + Sbjct: 330 RHLSLGHGIHRCLGAHLIRVEARVAITEFLKRIP 363 >2ZQJ-A nrPDB Length = 417 Score = 144 bits (364), Expect = 7e-35, Method: Composition-based stats. Identities = 72/432 (16%), Positives = 140/432 (32%), Gaps = 42/432 (9%) Query: 34 LGHGWRLARDPLAFMSQL-RDH-GDVVRIKLGPKTVYAVTNPELTGALALNPDYHIAGPL 91 L + L ++ F+ + D+ + +L K +T E + L Sbjct: 11 LDNSLTLLKEGYLFIKNRTERYNSDLFQARLLGKNFICMTGAEAAKVFYDTDRFQRQNAL 70 Query: 92 WESLEG-LLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGK 150 + ++ L G + +G H ++ +M EE A RW+ Sbjct: 71 PKRVQKSLFGVNAIQGMDGSAHIHRKMLFLSLMTPPHQKRLAELMTEEWKAAVTRWEKAD 130 Query: 151 TVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPL 210 V E+ + RVA C G + E + + MV G + Sbjct: 131 EVVLFEEAKEILCRVA--CYWAGVPLKETEVKER-------ADDFIDMVDAFGAV----G 177 Query: 211 PANRRFNDALADLHLLVDEIIAERRASGQKP--DDLLTALLEAKDDNGDPIGEQEIHDQV 268 P + + A ++ +I + RA K L + ++G + + ++ Sbjct: 178 PRHWKGRRARPRAEEWIEVMIEDARAGLLKTTSGTALHEMAFHTQEDGSQLDSRMAAIEL 237 Query: 269 VAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVI 328 + +L P I+ +++ AL +HP++ + +R R + Sbjct: 238 INVLRPIV-AISYFLVFSALALHEHPKYKEWLRS----------------GNSREREMFV 280 Query: 329 VEAMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWL 388 E R P L + G ++ Y DP+ +D EF P+R+ Sbjct: 281 QEVRRYYPFGPFLGALVKKDFVWNNCEFKKGTSVLLDLYGTNHDPRLWDHPDEFRPERF- 339 Query: 389 PERAANVPKYAMKPFSAGK----RKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVR 444 ER N+ + M P G +CP + ++ + L + ++ S Sbjct: 340 AEREENL--FDMIPQGGGHAEKGHRCPGEGITIEVMKASLDFLVHQIEYDVPEQSLHYSL 397 Query: 445 VGITLRPHDLLV 456 + P V Sbjct: 398 ARMPSLPESGFV 409 >3AWQ-A nrPDB Length = 415 Score = 139 bits (349), Expect = 4e-33, Method: Composition-based stats. Identities = 79/447 (17%), Positives = 137/447 (30%), Gaps = 57/447 (12%) Query: 16 PGAPELREPPVAGGGVPLLGHGWRLARDPLAFMSQ-LRDHG-DVVRIKLGPKTVYAVTNP 73 P P + P L DP F+S+ + G + + K + Sbjct: 2 PKTPHTKGP----------DETLSLLADPYRFISRQCQRLGANAFESRFLLKKTNCLKGA 51 Query: 74 ELTGALALNPDYHIAGPLWESLE-GLLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYG 132 + + G + +++ L G+ GV +G HR +++ + + A Sbjct: 52 KAAEIFYDTTRFEREGAMPVAIQKTLFGQGGVQGLDGETHRHRKQMFMGLMTPERVRALA 111 Query: 133 PIMEEEAHALTERWQPGKTVDATSESFRVAVRVAARCLLRGQYM-DERAERLCVALATVF 191 + E E W + E A C G + D+ A L +F Sbjct: 112 QLFEAEWRRAVPGWTRKGEIVFYDELHE--PLTRAVCAWAGVPLPDDEAGNRAGELRALF 169 Query: 192 RGMYRRMVVPLGPLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEA 251 P RL A + II RA A A Sbjct: 170 D--AAGSASPRHLWSRL----------ARRRVDAWAKRIIEGIRAGSIGSGSGTAAYAIA 217 Query: 252 --KDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTG 309 +D + D + ++V +L P + IA I ++ AL + + + Sbjct: 218 WHRDRHDDLLSPHVAAVELVNVLRP-TVAIAVYITFVAHALQTCSGIRAALVQQPD---- 272 Query: 310 GRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAI 369 + + E R P + RA + E G P G ++ Y Sbjct: 273 -------------YAELFVQEVRRFYPFFPAVVARASQDFEWEGMAFPEGRQVVLDLYGS 319 Query: 370 QRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGK----RKCPSDHFSMAQLTLITA 425 D ++ D EF P+R+ RA + + P G +CP + +A + + Sbjct: 320 NHDAATWADPQEFRPERF---RAWDEDSFNFIPQGGGDHYLGHRCPGEWIVLAIMKVAAH 376 Query: 426 AL--ATKYRFEQVAGSNDAVRVGITLR 450 L A +Y S D R+ + Sbjct: 377 LLVNAMRYDVPDQDLSIDFARLPALPK 403 >3NV6-A nrPDB Length = 452 Score = 134 bits (338), Expect = 7e-32, Method: Composition-based stats. Identities = 65/387 (16%), Positives = 122/387 (31%), Gaps = 49/387 (12%) Query: 57 VVRIKLGPKTVYAVTNPELTGALALNPDYHIAGPLWESLEGLLGKEGVAT-ANGPLHRRQ 115 + G + TN + + +P + ++ E + V T + P H Sbjct: 90 IWTPFTGGH--WIATNGDTVKEVYSDPTRFSSEVIFLPKEAGEKYQMVPTKMDPPEHTPY 147 Query: 116 RRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDATSESFRVAVRVAARCLLRGQY 175 R+ + L I + E A +L + + D +E + V L Sbjct: 148 RKALDKGLNLAKIRKVEDKVREVASSLIDSFAARGECDFAAEYAEL-FPVHVFMALADLP 206 Query: 176 MDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALADLHLLVDEIIAERR 235 +++ V R+M P G P + VD II R Sbjct: 207 LEDIP---------VLSEYARQMTRPEG---NTPEEMATDLEAGNNGFYAYVDPIIRAR- 253 Query: 236 ASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPE 295 G DDL+T ++ ++ NG+ I + + +L G +T+ + + + + LA HPE Sbjct: 254 -VGGDGDDLITLMVNSEI-NGERIAHDKAQGLISLLLLGGLDTVVNFLSFFMIHLARHPE 311 Query: 296 HADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESELGGYR 355 +R + + G E R P V R + E G Sbjct: 312 LVAELRSDPLKLMRGA-----------------EEMFRRFPVV-SEARMVAKDQEYKGVF 353 Query: 356 IPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHF 415 + G I+ D + + + D R + F G +C H Sbjct: 354 LKRGDMILLPTALHGLDDAANPEPWKLDFSR---------RSISHSTFGGGPHRCAGMHL 404 Query: 416 SMAQLTLITAALATK---YRFEQVAGS 439 + ++ + + + F++ Sbjct: 405 ARMEVIVTLEEWLKRIPEFSFKEGETP 431 >5M0P-A nrPDB Length = 428 Score = 134 bits (337), Expect = 8e-32, Method: Composition-based stats. Identities = 73/433 (16%), Positives = 140/433 (32%), Gaps = 48/433 (11%) Query: 34 LGHGWRLARDPLAFMSQLRDH--GDVVRIK-LGPKTVYAVTNPELTGALALNPDYHIAGP 90 L + ++ + + + R+ V + K LG K VT E N G Sbjct: 16 LDNTLKVLKQGYLYTTNQRNRLNTSVFQTKALGGKPFVVVTGKEGAEMFYNNDVVQREGM 75 Query: 91 LW-ESLEGLLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPG 149 L + L GK + T +G H ++ + + HA T+R + Sbjct: 76 LPKRIVNTLAGKGAIHTVDGKKHVDRKALFMSLMTEGNLNYVRELTRTLWHANTQRMESM 135 Query: 150 KTVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLP 209 V+ E + + G + +R + Y+ Sbjct: 136 DEVNIYRE--SIVLLTKVGTRWAGVQAPPEDIERIATDMDIMIDSFRALG-GAFKGYKAS 192 Query: 210 LPANRRFNDALADLHLLVDEIIAERRASGQKPDDL-LTALLEAKDDNGDPIGEQ----EI 264 A RR D L + +II R+ + P+ L +D G+P+ + ++ Sbjct: 193 KEARRRVEDWLEE------QIIETRKGNIHPPEGTALYEFAHWEDYLGNPMDSRTCAIDL 246 Query: 265 HDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHT 324 + ++ I + + L A+ ++P ++I+ E + + Sbjct: 247 MNTFRPLIA-----INRFVSFGLHAMNENPITREKIKSEPD-----------------YA 284 Query: 325 GNVIVEAMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDP 384 E R P V L +A + + G IPAG + Y D +DD EF P Sbjct: 285 YKFAQEVRRYYPFVPFLPGKAKVDIDFQGVTIPAGVGLALDVYGTTHDESLWDDPNEFRP 344 Query: 385 DRWLPERAANVPKYAMKPFSAG----KRKCPSDHFSMAQLTLITAALATKYRFEQVAGSN 440 +R+ + + + P G +C + ++ + A K ++ V + Sbjct: 345 ERFETWDGS---PFDLIPQGGGDYWTNHRCAGEWITVIIMEETMKYFAEKITYD-VPEQD 400 Query: 441 DAVRVGITLRPHD 453 V + Sbjct: 401 LEVDLNSIPGYVK 413 >5KYO-A nrPDB Length = 430 Score = 130 bits (328), Expect = 1e-30, Method: Composition-based stats. Identities = 54/354 (15%), Positives = 113/354 (31%), Gaps = 52/354 (14%) Query: 105 ATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDATSESFR-VAV 163 + + P HR R + + ++ + A +L E ++P + T E + V Sbjct: 123 LSLDPPEHRPFRSLLNENLGPKPLRPIEQVVTDLAVSLIEGFRPKGRCNFTHEFAEQLPV 182 Query: 164 RVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALADL 223 R+ R + + + L P +PL +D Sbjct: 183 RIFMRIVDLPVEDLPKLKHLADQYTR--------------PDGSIPL------DDVTKQF 222 Query: 224 HLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTI 283 + +I RR + +D+++ ++ + G P+ + E + + +L G +T+ + + Sbjct: 223 REYLRPVIEARR--IKPGEDMISRMINGEV-GGRPLTDIEAENICIQVLVGGLDTVVNML 279 Query: 284 MWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTR 343 + LA I + + + ++E R P V R Sbjct: 280 GFTFSHLAKDHALRRAIAADPSLI-----------------DDALLEFFRRFPVVSS-AR 321 Query: 344 RAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPF 403 + + E G + AG ++ + D +D LEF R F Sbjct: 322 EVLRDQEFEGVLLKAGDMVMAPTVVVAMDDARNEDPLEFRLGR---------KARQHSTF 372 Query: 404 SAGKRKCPSDHFSMAQLTLITAALATKYR-FEQVAGSNDAVRVGITLRPHDLLV 456 G CP H + ++ ++ + F + GI ++ Sbjct: 373 GKGSHTCPGAHLARMEMKVVLREWFARIPEFRIEDDAPLRYSNGIVGSVKPFVL 426 >2QBO-A nrPDB Length = 421 Score = 129 bits (325), Expect = 2e-30, Method: Composition-based stats. Identities = 75/458 (16%), Positives = 149/458 (32%), Gaps = 55/458 (12%) Query: 1 MTVESVNPETRAPAAPGAPELREPPVAGGGVPLLGHGWRLARDPLAFMSQLRDHGDVVRI 60 MT E++ ++ A AP P + E V + + ++ A + + + D+V Sbjct: 1 MTTETI--QSNANLAPLPPHVPEHLVFDFDMYNPSNLSAGVQEAWAVLQES-NVPDLVWT 57 Query: 61 KLGPKTVYAVTNPELTGALALNPDYHIAG-PLWESLEGLLGKEGVATANGPLHRRQRRTI 119 + + T +L + + + P G + + P R+ R Sbjct: 58 RCNG-GHWIATRGQLIREAYEDYRHFSSECPFIPREAGEAYDFIPTSMDPPEQRQFRALA 116 Query: 120 QPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDATSESFRVAVRVAARCLLRGQYMDER 179 + + ++E A +L E +P + T + + + LL G ++ Sbjct: 117 NQVVGMPVVDKLENRIQELACSLIESLRPQGQCNFTED-YAEPFPIRIFMLLAGLPEEDI 175 Query: 180 AERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQ 239 + +M P G + F +A L+ + II +RR + Sbjct: 176 PHLKYLT---------DQMTRPDGSM---------TFAEAKEALYDYLIPIIEQRRQ--K 215 Query: 240 KPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADR 299 D ++ + + NG PI E +L G +T+ + + + ++ LA PEH Sbjct: 216 PGTDAISIVANGQV-NGRPITSDEAKRMCGLLLVVGLDTVVNFLSFSMEFLAKSPEHRQE 274 Query: 300 IRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESELGGYRIPAG 359 + + E + E +R V R ++ E G ++ G Sbjct: 275 LIERPERIP-----------------AACEELLRRFSLV-ADGRILTSDYEFHGVQLKKG 316 Query: 360 ADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQ 419 I+ D + + D R K + F G C H + + Sbjct: 317 DQILLPQMLSGLDERENACPMHVDFSR---------QKVSHTTFGHGSHLCLGQHLARRE 367 Query: 420 LTLITAALATKY-RFEQVAGSNDAVRVGITLRPHDLLV 456 + + T+ F G+ + GI L + Sbjct: 368 IIVTLKEWLTRIPDFSIAPGAQIQHKSGIVSGVQALPL 405 >2IJ7-A nrPDB Length = 396 Score = 127 bits (320), Expect = 8e-30, Method: Composition-based stats. Identities = 59/403 (14%), Positives = 128/403 (31%), Gaps = 55/403 (13%) Query: 49 SQLRDHGDVVRIK-LGPKTVYAVTNPELTGALALNPDY---HIAGPLWESLEGLLGKEGV 104 ++LR + +++ + + V++ L + + + A L L V Sbjct: 23 AELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRFSMKETAAAGAPRLNALTVPPEV 82 Query: 105 ATANGPLHRR-QRRTIQPAFRLDAIPAYGPIMEEEAHALTERW-QPGKTVDATSESFRVA 162 G + R+ + A A P + + A++L + G D ++ F Sbjct: 83 VNNMGNIADAGLRKAVMKAITPKA-PGLEQFLRDTANSLLDNLITEGAPADLRND-FADP 140 Query: 163 VRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALAD 222 + A C + G ++ + +FR + + P+ + +R Sbjct: 141 LATALHCKVLGIPQEDGPK--------LFRSLSIAFMSSADPIPAAKINWDRDIE----- 187 Query: 223 LHLLVDEIIAERRASGQKPDDLLTALLEAKDDNG-DPIGEQEIHDQVVAILTPGSETIAS 281 + I+ + L+ L + D + ++ V G + S Sbjct: 188 ---YMAGILE----NPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGS 240 Query: 282 TIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLR-PAVWV 340 + L +L P+ + + ++ E + G + E +R+ Sbjct: 241 FLTTALISLIQRPQLRNLLHEKPELIPAG-----------------VEELLRINLSFADG 283 Query: 341 LTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAM 400 L R A A+ ++G + G ++ DP+ + + + DR P + Sbjct: 284 LPRLATADIQVGDVLVRKGELVLVLLEGANFDPEHFPNPGSIELDRPNPT--------SH 335 Query: 401 KPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAV 443 F G+ CP + AL K +A D + Sbjct: 336 LAFGRGQHFCPGSALGRRHAQIGIEALLKKMPGVDLAVPIDQL 378 >3B98-A nrPDB Length = 475 Score = 127 bits (319), Expect = 1e-29, Method: Composition-based stats. Identities = 77/476 (16%), Positives = 166/476 (34%), Gaps = 61/476 (12%) Query: 23 EPPVAGGGVPLLGHGWRLARDPLAFMSQLR-DHGDVVRIKLGPKTVYAVTNPELTGALAL 81 EPP+ G +P LGH +D F+++++ HGD+ ++ + + + A+ Sbjct: 19 EPPLDKGMIPWLGHALEFGKDAAKFLTRMKEKHGDIFTVRAAGLYITVLLDSNCYDAVLS 78 Query: 82 NPDYHIAGPLWESLEGLLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHA 141 + + L + + ++ P ++R + F+ ++ M+ Sbjct: 79 DVASLDQTSYAQVLMKRIF-NMILPSHNPESEKKRAEMH--FQGASLTQLSNSMQNNLRL 135 Query: 142 LT---------ERWQPGKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFR 192 L W+ + + + + + + + A F Sbjct: 136 LMTPSEMGLKTSEWKKDGLFNL---CYSLLFKTGYLTVFGAENNNSAALTQIYEEFRRFD 192 Query: 193 GMYRRMVVPLGPLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAK 252 + ++ + + + A L + +R+ Q L + ++ Sbjct: 193 KLLPKLARTT-----VNKEEKQIASAAREKLWKWLTPSGLDRKPREQS---WLGSYVKQL 244 Query: 253 DDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRP 312 D G E + ++ + + W++ L HPE +R+E++ GG+ Sbjct: 245 QDEGID-AEMQRRAMLLQLWVTQGNAGPAAF-WVMGYLLTHPEALRAVREEIQ---GGKH 299 Query: 313 VAFEDVRK-LRHTGNVIVEAMRLRPAVWVLTRRAVAESEL-----GGYRIPAGADIIYSP 366 + E+ +K +V+ E +RL A ++TR + ++ Y + G + P Sbjct: 300 LRLEERQKNTPVFDSVLWETLRLTAAA-LITRDVTQDKKICLSNGQEYHLRRGDRLCVFP 358 Query: 367 Y-AIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRK-------------CPS 412 + + Q DP+ + F DR+L + F G R CP Sbjct: 359 FISPQMDPQIHQQPEMFQFDRFLNADRTEKKDF----FKNGARVKYPSVPWGTEDNLCPG 414 Query: 413 DHFSMAQLTLITAALATKYRFEQVAGSN-----DAVRVGI-TLRPH-DLLVRPVAR 461 HF++ + + + T++ E + D R G L+P DL +R R Sbjct: 415 RHFAVHAIKELVFTILTRFDVELCDKNATVPLVDPSRYGFGILQPAGDLEIRYRIR 470 >4C9K-A nrPDB Length = 421 Score = 127 bits (318), Expect = 1e-29, Method: Composition-based stats. Identities = 73/390 (18%), Positives = 128/390 (32%), Gaps = 45/390 (11%) Query: 56 DVVRIKLGPKTVYAVTNPELTGALALNPDYHIAGPLWESLEGLLGKEGVAT-ANGPLHRR 114 +V + T L + +P+ + +W E + V T + P H Sbjct: 54 PLVWTPFTG-GHWIATRGTLIDEIYRSPERFSSRVIWVPREAGEAYDMVPTKLDPPEHTP 112 Query: 115 QRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDATSESFRVAVRVAARCLLRGQ 174 R+ I L I + A + E + + SE F V L G Sbjct: 113 YRKAIDKGLNLAEIRKLEDQIRTIAVEIIEGFADRGHCEFGSE-FSTVFPVRVFLALAGL 171 Query: 175 YMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALADLHLLVDEIIAER 234 +++ A +L + + R P P R A V IIA R Sbjct: 172 PVED-ATKLGLLANEMTR-----------PSGNTPEEQGRSLEAANKGFFEYVAPIIAAR 219 Query: 235 RASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHP 294 R G DL+T +L + D G P+ + V +L G +T+ + + +++ L+ HP Sbjct: 220 R--GGSGTDLITRILNVEID-GKPMPDDRALGLVSLLLLGGLDTVVNFLGFMMIYLSRHP 276 Query: 295 EHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESELGGY 354 E +R E + G + E R V R V++ E G Sbjct: 277 ETVAEMRREPLKLQRG-----------------VEELFRRFAVV-SDARYVVSDMEFHGT 318 Query: 355 RIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDH 414 + G I+ D + +DD + D R F+ G +C H Sbjct: 319 MLKEGDLILLPTALHGLDDRHHDDPMTVDLSR---------RDVTHSTFAQGPHRCAGMH 369 Query: 415 FSMAQLTLITAALATKYRFEQVAGSNDAVR 444 + ++T++ + ++ + Sbjct: 370 LARLEVTVMLQEWLARIPEFRLKDRAVPIY 399 >2IAG-A nrPDB Length = 482 Score = 127 bits (318), Expect = 1e-29, Method: Composition-based stats. Identities = 83/478 (17%), Positives = 160/478 (33%), Gaps = 46/478 (9%) Query: 23 EPPVAGGGVPLLGHGWRLARDPLAFMSQLR-DHGDVVRIKLGPKTVYAVTNPELTGALAL 81 EPP+ G +P LG+ +D +F+++++ HGD+ I +G + V + +P A+ Sbjct: 7 EPPLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTVLLDPHSYDAVVW 66 Query: 82 NPDYHIAGPLWES--LEGLLGKEGVATANGPLHRRQRRTI-----QPAFRLDAIPAYGPI 134 P + + +E + + + + + + + A + Sbjct: 67 EPRTRLDFHAYAIFLMERIFDVQ-LPHYSPSDEKARMKLTLLHRELQALTEAMYTNLHAV 125 Query: 135 MEEEAHALTERWQPGKTVDA-TSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRG 193 + +A W +D S R + + +A+ + Sbjct: 126 LLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTLYGIEALPRTHESQAQDRVHSADVFHTF 185 Query: 194 MYRRMVVPLGPLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKD 253 ++P L + + L L+ RRA K L + L + Sbjct: 186 RQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSK---WLESYLLHLE 242 Query: 254 DNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPV 313 + G + E+ +V L + WLL L +PE +R E+E++ Sbjct: 243 EMG--VSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQ 300 Query: 314 AFEDVRKLRH--------TGNVIVEAMRLRPAVWVLTRRAVAESEL-----GGYRIPAGA 360 L +V+ E++RL A +TR V + + + + G Sbjct: 301 PVSQTTTLPQKVLDSTPVLDSVLSESLRL-TAAPFITREVVVDLAMPMADGREFNLRRGD 359 Query: 361 DIIYSP-YAIQRDPKSYDDNLEFDPDRWLPERAANVPKY---------AMKPFSAGKRKC 410 ++ P + QRDP+ Y D F +R+L + + P+ AG C Sbjct: 360 RLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHC 419 Query: 411 PSDHFSMAQLTLITAALATKYRFEQVAGSN-----DAVRVGITLRP--HDLLVRPVAR 461 +++ + + E + D R G L HD+ VR R Sbjct: 420 LGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQPEHDVPVRYRIR 477 >3DBM-A nrPDB Length = 473 Score = 114 bits (284), Expect = 1e-25, Method: Composition-based stats. Identities = 80/484 (16%), Positives = 156/484 (32%), Gaps = 71/484 (14%) Query: 16 PGAPELREPPVAGGGVPLL--------GHGWRLARDPLAFMSQLRDH-GDVVRIKLGPKT 66 P + LRE P G+P RD F S+++ + V R + P Sbjct: 3 PSSKPLREIP-GSYGIPFFQPIKDRLEYFYGTGGRDEY-FRSRMQKYQSTVFRANMPPGP 60 Query: 67 -------VYAVTN----PELTGALALNPDYHIAGPLWESLEGLLGKEGVATANG--PLHR 113 V + + P L + G S + G ++ + P H Sbjct: 61 FVSSNPKVIVLLDAKSFPILFDVSKVEKKDLFTGTYMPSTKLTGGYRVLSYLDPSEPRHA 120 Query: 114 RQRRTIQPAF---RLDAIPAYGPIMEEEAHALTERWQPGKTVDATSESFRVAVRVAARCL 170 + + + IP + E L + A R R Sbjct: 121 QLKNLLFFMLKNSSNRVIPQFETTYTELFEGLEAELAKNGKAAFNDVGEQAAFRFLGRAY 180 Query: 171 LRGQYMDERAERLCVALAT--VFRGMYRRMVVPLGPLYRLPLPANRRFNDAL-----ADL 223 + + L + V + + + L + PL R L L Sbjct: 181 FNSNPEETKLGTSAPTLISSWVLFNLAPTLDLGLPWFLQEPLLHTFRLPAFLIKSTYNKL 240 Query: 224 HLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILT---PGSETI- 279 + + T ++E + G P ++ +H+ + A+ G + + Sbjct: 241 YDYFQSVA--------------TPVMEQAEKLGVP-KDEAVHNILFAVCFNTFGGVKILF 285 Query: 280 ASTIMW-LLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAV 338 +T+ W L H + A+ IR +++ G V E + ++ T +V+ E++R+ P V Sbjct: 286 PNTLKWIGLAGENLHTQLAEEIRGAIKSY-GDGNVTLEAIEQMPLTKSVVYESLRIEPPV 344 Query: 339 WVLTRRAVAESEL----GGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAAN 394 +A + + + + G + +DPK +D E+ PDR++ + A Sbjct: 345 PPQYGKAKSNFTIESHDATFEVKKGEMLFGYQPFATKDPKVFDRPEEYVPDRFVGDGEAL 404 Query: 395 VPKYAMKPFSAGK---------RKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRV 445 + +S G ++C F + L L +Y ++ + Sbjct: 405 LK---YVWWSNGPETESPTVENKQCAGKDFVVLITRLFVIELFRRYDSFEIELGESPLGA 461 Query: 446 GITL 449 +TL Sbjct: 462 AVTL 465 >2RCM-A nrPDB Length = 495 Score = 105 bits (262), Expect = 4e-23, Method: Composition-based stats. Identities = 75/455 (16%), Positives = 140/455 (30%), Gaps = 67/455 (14%) Query: 26 VAGGGVPLLGHG---WRLARDPLA---FMSQLRDH-GDVVRIKLGPKTVYAVTNPELTGA 78 G+P++G W D A F S++R + V R+ + P + NP++ Sbjct: 31 PGNYGLPIVGPIKDRWDYFYDQGAEEFFKSRIRKYNSTVYRVNMPP-GAFIAENPQVVAL 89 Query: 79 LALN-----------PDYHIAGPLWESLEGLLGKEGVA-TANGPLHRR-----QRRTIQP 121 L + + L G + + + + Sbjct: 90 LDGKSFPVLFDVDKVEKKDLLTGTYMPSTELTGGYRILSYLDPSEPKHEKLKNLLFFLLK 149 Query: 122 AFRLDAIPAYGPIMEEEAHALTERWQPGKTVDATSESFRVAVRVAARCLLRGQYMDERAE 181 + R P + E +L + D S A AR D + + Sbjct: 150 SSRNRIFPEFQATYSELFDSLEKELSLKGKADFGGSSDGTAFNFLARAFYGTNPADTKLK 209 Query: 182 RLCVALAT----------VFRGMYRRMVVPLGPLYRLPLPANR-RFNDALADLHLLVDEI 230 L T + G+ R + PL + LP + + EI Sbjct: 210 ADAPGLITKWVLFNLHPLLSIGLPRVIEEPLIHTFSLPPALVKSDYQRLYEFFLESAGEI 269 Query: 231 IAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQAL 290 + E G ++ LL A N + + V I G Sbjct: 270 LVEADKLGISREEATHNLLFATCFNTWGGMKILFPNMVKRIGRAGH-------------- 315 Query: 291 ADHPEHADRIRDEVEAVTGGR--PVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAE 348 + +R+ +E+ +V + + K+ T +V+ E +R P V RA + Sbjct: 316 ----QVHNRLAEEIRSVIKSNGGELTMGAIEKMELTKSVVYECLRFEPPVTAQYGRAKKD 371 Query: 349 SELGG----YRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFS 404 + +++ AG + RDPK +D EF P+R++ E + ++ + Sbjct: 372 LVIESHDAAFKVKAGEMLYGYQPLATRDPKIFDRADEFVPERFVGEEGEKLLRHVLWSNG 431 Query: 405 -------AGKRKCPSDHFSMAQLTLITAALATKYR 432 G ++C F + L + +Y Sbjct: 432 PETETPTVGNKQCAGKDFVVLVARLFVIEIFRRYD 466 >2YJN-B nrPDB Length = 381 Score = 68.6 bits (166), Expect = 5e-12, Method: Composition-based stats. Identities = 34/128 (26%), Positives = 57/128 (44%), Gaps = 17/128 (13%) Query: 272 LTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEA 331 L G+E A+T++ + A++ P A+RI D+ A + E Sbjct: 220 LFAGAEMTANTVVDAVLAVSAEPGLAERIADDPAA-----------------AQRTVAEV 262 Query: 332 MRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPER 391 +RL PA+ + R A AE LG + I G +++ A RDP+ + + D DR +R Sbjct: 263 LRLHPALHLERRTATAEVRLGEHVIGEGEEVVVVVAAANRDPEVFAEPDRLDVDRPDADR 322 Query: 392 AANVPKYA 399 A + + Sbjct: 323 ALSAHRGH 330 >3IAC-A nrPDB Length = 473 Score = 32.0 bits (71), Expect = 0.57, Method: Composition-based stats. Identities = 26/158 (16%), Positives = 49/158 (31%), Gaps = 10/158 (6%) Query: 117 RTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDATSESFRVAVRVAARCLLRGQYM 176 + PAF I M++ + +D+ ++A + + + Sbjct: 138 KLATPAFSARGI------MQQMNVRMV--GTTDDPIDSLEYHRQIAADDSIDIEVAPSWR 189 Query: 177 DER-AERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALADLHLLVDEIIAERR 235 ++ + R + V + L RR + A D I R Sbjct: 190 PDKVFKIELDGFVDYLRKLEAAADVSITRFDDLRQALTRRLDHFAACGCRASDHGIETLR 249 Query: 236 ASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILT 273 + D L A+L + G+ + E EI A+L Sbjct: 250 FAPVPDDAQLDAILGKRLA-GETLSELEIAQFTTAVLV 286 >5L9W-B nrPDB Length = 732 Score = 31.2 bits (69), Expect = 0.86, Method: Composition-based stats. Identities = 21/86 (24%), Positives = 40/86 (46%), Gaps = 10/86 (11%) Query: 228 DEIIAERR--ASGQKP-----DDLLTALLEAKDDNGD---PIGEQEIHDQVVAILTPGSE 277 + +AERR A KP DL+ + E D +G P+ E+++ ++ ++ G+ Sbjct: 115 GQRVAERRNIAVQNKPLPLIERDLILGVRERIDSSGSVVRPLDEEDVRTKLRMLMDRGAR 174 Query: 278 TIASTIMWLLQALADHPEHADRIRDE 303 I +++W A + IR+E Sbjct: 175 AIVVSLLWSFMNPAHEKRVREIIREE 200 >4YXC-B nrPDB Length = 227 Score = 30.8 bits (68), Expect = 1.1, Method: Composition-based stats. Identities = 13/90 (14%), Positives = 32/90 (35%), Gaps = 7/90 (7%) Query: 278 TIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLR-P 336 T + + + + ++ +++ + ++ + T I E +RL Sbjct: 119 TTTKSAADAVFQQLGGGDVSGAMQ-DIDLIMDIPVKLTVELGR---TRMTIKELLRLTQG 174 Query: 337 AVWVLTRRAVA--ESELGGYRIPAGADIIY 364 +V L A + + GY I G ++ Sbjct: 175 SVVALDGLAGEPLDILINGYLIAQGEVVVV 204 >4YXB-D nrPDB Length = 80 Score = 29.7 bits (65), Expect = 2.6, Method: Composition-based stats. Identities = 15/56 (26%), Positives = 24/56 (42%), Gaps = 5/56 (8%) Query: 314 AFEDV--RKLRHTGNVIVEAMRLR-PAVWVLTRRAVA--ESELGGYRIPAGADIIY 364 A +D+ +L T I E +RL +V L A + + GY I G ++ Sbjct: 2 ALDDLWADELGRTRMTIKELLRLTQGSVVALDGLAGEPLDILINGYLIAQGEVVVV 57 >3RFT-A nrPDB Length = 267 Score = 29.3 bits (64), Expect = 3.6, Method: Composition-based stats. Identities = 8/52 (15%), Positives = 14/52 (26%), Gaps = 11/52 (21%) Query: 367 YAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMA 418 + Y PD +P R + G KC ++ + Sbjct: 109 ASSNHTIGYYPQTERLGPD--VPARPDGL---------YGVSKCFGENLARM 149 >6MDR-a nrPDB Length = 247 Score = 29.3 bits (64), Expect = 3.7, Method: Composition-based stats. Identities = 8/22 (36%), Positives = 14/22 (63%) Query: 278 TIASTIMWLLQALADHPEHADR 299 T+ +T+ W +Q A +P+H R Sbjct: 60 TLVTTLTWGVQCFARYPKHMKR 81 >1BWD-A nrPDB Length = 348 Score = 28.1 bits (61), Expect = 8.4, Method: Composition-based stats. Identities = 13/73 (17%), Positives = 28/73 (38%) Query: 205 LYRLPLPANRRFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEI 264 + P+ RF ++LA LL++ + R L + G+ + ++E Sbjct: 117 IIETPMALRSRFLESLAYKDLLLEYFASGSRWLSAPKPRLTDDSYAPQAPAGERLTDEEP 176 Query: 265 HDQVVAILTPGSE 277 +L G++ Sbjct: 177 VFDAANVLRFGTD 189 >3OQB-A nrPDB Length = 383 Score = 27.8 bits (60), Expect = 9.5, Method: Composition-based stats. Identities = 11/48 (22%), Positives = 20/48 (41%), Gaps = 3/48 (6%) Query: 344 RAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDD-NLEFDPDRWLPE 390 A+ + GG R+ G I+ P + R + + F+ RW + Sbjct: 29 VAIRDQ--GGVRLKNGDRIMPDPILVGRSAEKVEALAKRFNIARWTTD 74 >1PQ3-A nrPDB Length = 306 Score = 27.8 bits (60), Expect = 9.9, Method: Composition-based stats. Identities = 15/84 (17%), Positives = 25/84 (29%), Gaps = 4/84 (4%) Query: 61 KLGPKTVYAVTNPELTGALALNPDYHIAGPLWESLEGLLGKEGVATANGPLHRRQRRTIQ 120 L + V + EL + P + P S + G+ + P H + Sbjct: 135 NLHGQPVSFLLR-ELQDKVPQLPGFSWIKPCISSASIVY--IGLRDVDPPEHFILKNYDI 191 Query: 121 PAFRLDAIPAYG-PIMEEEAHALT 143 F + I G + E L Sbjct: 192 QYFSMRDIDRLGIQKVMERTFDLL 215 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.312 0.130 0.344 Lambda K H 0.267 0.0398 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 16,944,535 Number of Sequences: 36641 Number of extensions: 678460 Number of successful extensions: 2995 Number of sequences better than 10.0: 181 Number of HSP's better than 10.0 without gapping: 282 Number of HSP's successfully gapped in prelim test: 63 Number of HSP's that attempted gapping in prelim test: 1865 Number of HSP's gapped (non-prelim): 368 length of query: 461 length of database: 10,336,785 effective HSP length: 100 effective length of query: 361 effective length of database: 6,672,685 effective search space: 2408839285 effective search space used: 2408839285 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.4 bits) S2: 61 (28.1 bits)