BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q9JII6 (325 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 4GAC-A nrPDB 672 0.0 2ALR-A nrPDB 634 0.0 1HQT-A nrPDB 623 e-179 1ZUA-X nrPDB 326 1e-89 1DLA-A nrPDB 310 5e-85 1FRB-A nrPDB 304 3e-83 3RX4-A nrPDB 297 4e-81 1C9W-A nrPDB 297 4e-81 3O3R-A nrPDB 295 3e-80 4HBK-A nrPDB 292 1e-79 2FVL-A nrPDB 281 4e-76 4JQA-A nrPDB 279 1e-75 5JH1-A nrPDB 273 6e-74 3G1R-A nrPDB 272 1e-73 1Q5M-A nrPDB 268 2e-72 5JM5-A nrPDB 266 1e-71 5UXF-A nrPDB 261 2e-70 2HE8-A nrPDB 253 9e-68 3H7U-A nrPDB 253 1e-67 5ZCM-A nrPDB 252 2e-67 1AFS-A nrPDB 249 1e-66 3H7R-A nrPDB 240 6e-64 3WCZ-A nrPDB 232 1e-61 1K8C-A nrPDB 231 5e-61 5Z6T-A nrPDB 229 1e-60 4F40-A nrPDB 228 3e-60 3KRB-A nrPDB 222 2e-58 4GIE-A nrPDB 219 1e-57 2BGQ-A nrPDB 217 5e-57 1VBJ-A nrPDB 214 5e-56 1QWK-A nrPDB 212 2e-55 3D3F-A nrPDB 207 6e-54 1MZR-A nrPDB 194 4e-50 1VP5-A nrPDB 184 4e-47 4MHB-A nrPDB 179 1e-45 1A80-A nrPDB 172 2e-43 4IJC-A nrPDB 167 4e-42 4OTK-A nrPDB 162 2e-40 3UP8-A nrPDB 158 4e-39 3WG6-A nrPDB 138 3e-33 4H8N-A nrPDB 120 1e-27 1PYF-A nrPDB 63 2e-10 1LQA-A nrPDB 60 2e-09 1PZ1-A nrPDB 57 8e-09 3N6Q-A nrPDB 49 3e-06 3EB3-A nrPDB 47 9e-06 1GVE-A nrPDB 41 6e-04 1OG6-A nrPDB 38 0.005 4R9O-A nrPDB 36 0.022 2BP1-A nrPDB 35 0.048 5XKX-A nrPDB 34 0.11 2C91-A nrPDB 33 0.13 2CLP-A nrPDB 32 0.36 3PS9-A nrPDB 29 2.4 4F5M-A nrPDB 29 3.0 3EC2-A nrPDB 28 3.6 2QY6-A nrPDB 28 7.5 >4GAC-A nrPDB Length = 324 Score = 672 bits (1735), Expect = 0.0, Method: Compositional matrix adjust. Identities = 324/324 (100%), Positives = 324/324 (100%) Query: 2 TASSVLLHTGQKMPLIGLGTWKSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALK 61 TASSVLLHTGQKMPLIGLGTWKSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALK Sbjct: 1 TASSVLLHTGQKMPLIGLGTWKSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALK 60 Query: 62 ESVGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERG 121 ESVGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERG Sbjct: 61 ESVGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERG 120 Query: 122 DNPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVRPA 181 DNPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVRPA Sbjct: 121 DNPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVRPA 180 Query: 182 VLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEKH 241 VLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEKH Sbjct: 181 VLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEKH 240 Query: 242 GRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWRYIVP 301 GRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWRYIVP Sbjct: 241 GRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWRYIVP 300 Query: 302 MITVDGKRVPRDAGHPLYPFNDPY 325 MITVDGKRVPRDAGHPLYPFNDPY Sbjct: 301 MITVDGKRVPRDAGHPLYPFNDPY 324 >2ALR-A nrPDB Length = 324 Score = 634 bits (1635), Expect = 0.0, Method: Compositional matrix adjust. Identities = 302/324 (93%), Positives = 313/324 (96%) Query: 2 TASSVLLHTGQKMPLIGLGTWKSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALK 61 AS VLLHTGQKMPLIGLGTWKSEPGQVKAA+K+ALS GYRHIDCA++YGNE EIGEALK Sbjct: 1 AASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALK 60 Query: 62 ESVGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERG 121 E VG GKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERG Sbjct: 61 EDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERG 120 Query: 122 DNPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVRPA 181 DNPFPKNADGT+ YDSTHYKETWKALE LVAKGLV+ALGLSNFNSRQIDD+LSVASVRPA Sbjct: 121 DNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPA 180 Query: 182 VLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEKH 241 VLQVECHPYLAQNELIAHC ARGLEVTAYSPLGSSDRAWR PDEPVLLEEPVVLALAEK+ Sbjct: 181 VLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKY 240 Query: 242 GRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWRYIVP 301 GRSPAQILLRWQVQRKVICIPKSI PSRILQNI+VFDFTFSPEEMKQL+ALNKNWRYIVP Sbjct: 241 GRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIVP 300 Query: 302 MITVDGKRVPRDAGHPLYPFNDPY 325 M+TVDGKRVPRDAGHPLYPFNDPY Sbjct: 301 MLTVDGKRVPRDAGHPLYPFNDPY 324 >1HQT-A nrPDB Length = 326 Score = 623 bits (1606), Expect = e-179, Method: Compositional matrix adjust. Identities = 295/325 (90%), Positives = 312/325 (96%) Query: 1 MTASSVLLHTGQKMPLIGLGTWKSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEAL 60 M AS VLLHTGQKMPLIGLGTWKSEPGQVKAAIK+AL+ GYRHIDCA+++GNE EIGEAL Sbjct: 2 MAASCVLLHTGQKMPLIGLGTWKSEPGQVKAAIKYALTVGYRHIDCAAIFGNELEIGEAL 61 Query: 61 KESVGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFER 120 +E+VG GKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFER Sbjct: 62 QETVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFER 121 Query: 121 GDNPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVRP 180 GDNPFPKNADGT+RYD+THYK+TWKALE LVAKGLV+ALGLSNF+SRQIDDVLSVASVRP Sbjct: 122 GDNPFPKNADGTIRYDATHYKDTWKALEALVAKGLVRALGLSNFSSRQIDDVLSVASVRP 181 Query: 181 AVLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEK 240 AVLQVECHPYLAQNELIAHC ARGLEVTAYSPLGSSDRAWR P+EPVLLEEPVV ALAEK Sbjct: 182 AVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPNEPVLLEEPVVQALAEK 241 Query: 241 HGRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWRYIV 300 + RSPAQILLRWQVQRKVICIPKS+ PSRI QNIQVFDFTFSPEEMKQLDALNKN R+IV Sbjct: 242 YNRSPAQILLRWQVQRKVICIPKSVTPSRIPQNIQVFDFTFSPEEMKQLDALNKNLRFIV 301 Query: 301 PMITVDGKRVPRDAGHPLYPFNDPY 325 PM+TVDGKRVPRDAGHPLYPFNDPY Sbjct: 302 PMLTVDGKRVPRDAGHPLYPFNDPY 326 >1ZUA-X nrPDB Length = 317 Score = 326 bits (835), Expect = 1e-89, Method: Compositional matrix adjust. Identities = 163/325 (50%), Positives = 218/325 (67%), Gaps = 12/325 (3%) Query: 3 ASSVLLHTGQKMPLIGLGTWKSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALKE 62 A+ V L T KMP++GLGTWKS G+VK A+K A+ AGYRHIDCA VY NE E+GEA++E Sbjct: 3 ATFVELSTKAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQE 62 Query: 63 SVGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGD 122 + KAV RE+LF+ SKLW T V A KTL DL+L YLD+YL+HWP F+ GD Sbjct: 63 KIQE-KAVKREDLFIVSKLWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKSGD 121 Query: 123 NPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVR--P 180 + FPK+ G + + W+A+E LV +GLVKALG+SNF+ QI+ +L+ ++ P Sbjct: 122 DLFPKDDKGNAIGGKATFLDAWEAMEELVDEGLVKALGVSNFSHFQIEKLLNKPGLKYKP 181 Query: 181 AVLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEK 240 QVECHPYL Q +LI +CH++G+ VTAYSPLGS DR W P++P LLE+P + +A K Sbjct: 182 VTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPKIKEIAAK 241 Query: 241 HGRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWRYIV 300 H ++ AQ+L+R+ +QR VI IPKS+ P+RI++NIQVFDF S EEM + + N+NWR Sbjct: 242 HKKTAAQVLIRFHIQRNVIVIPKSVTPARIVENIQVFDFKLSDEEMATILSFNRNWR--- 298 Query: 301 PMITVDGKRVPRDAGHPLYPFNDPY 325 V + + YPFN Y Sbjct: 299 ------ACNVLQSSHLEDYPFNAEY 317 >1DLA-A nrPDB Length = 314 Score = 310 bits (795), Expect = 5e-85, Method: Compositional matrix adjust. Identities = 163/324 (50%), Positives = 224/324 (69%), Gaps = 12/324 (3%) Query: 4 SSVLLHTGQKMPLIGLGTWKSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALKES 63 S ++L+TG KMP++GLGTWKS PG+V A+K A+ GYRHIDCA VY NE E+G L+E Sbjct: 1 SHLVLYTGAKMPILGLGTWKSPPGKVTEAVKVAIDLGYRHIDCAHVYQNENEVGLGLQEK 60 Query: 64 VGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDN 123 + G+ V RE+LF+ SKLW T H V+ A + TL DL+L+YLDLYL+HWP F+ G + Sbjct: 61 L-QGQVVKREDLFIVSKLWCTDHEKNLVKGACQTTLRDLKLDYLDLYLIHWPTGFKPGKD 119 Query: 124 PFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVR--PA 181 PFP + DG V D + + ETW+A+E LV +GLVKA+G+SNFN Q++ +L+ ++ PA Sbjct: 120 PFPLDGDGNVVPDESDFVETWEAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYKPA 179 Query: 182 VLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEKH 241 V Q+E HPYL Q +LI +C ++G+ VTAYSPLGS DR W P++P LLE+P + A+A K+ Sbjct: 180 VNQIEVHPYLTQEKLIEYCKSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAKY 239 Query: 242 GRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWRYIVP 301 ++ AQ+L+R+ +QR +I IPKS+ P RI +N QVFDF SPE+M L + N+NWR Sbjct: 240 NKTTAQVLIRFPMQRNLIVIPKSVTPERIAENFQVFDFELSPEDMNTLLSYNRNWRVCAL 299 Query: 302 MITVDGKRVPRDAGHPLYPFNDPY 325 M A H YPF++ Y Sbjct: 300 MSC---------ASHKDYPFHEEY 314 >1FRB-A nrPDB Length = 315 Score = 304 bits (779), Expect = 3e-83, Method: Compositional matrix adjust. Identities = 161/316 (50%), Positives = 218/316 (68%), Gaps = 3/316 (0%) Query: 3 ASSVLLHTGQKMPLIGLGTWKSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALKE 62 A+ V L T KMP++GLGTWKS P QVK A+K A+ AGYRHIDCA Y NE E+GEA++E Sbjct: 1 ATFVELSTKAKMPIVGLGTWKSPPNQVKEAVKAAIDAGYRHIDCAYAYCNENEVGEAIQE 60 Query: 63 SVGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGD 122 + KAV RE+LF+ SKLW T + ++ A +KTL DL+L+YLDLYL+HWP + G Sbjct: 61 KIKE-KAVQREDLFIVSKLWPTCFEKKLLKEAFQKTLTDLKLDYLDLYLIHWPQGLQPGK 119 Query: 123 NPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVR--P 180 FPK+ G + T + E W+ +E LV +GLVKALG+SNFN QI+ +L+ ++ P Sbjct: 120 ELFPKDDQGRILTSKTTFLEAWEGMEELVDQGLVKALGVSNFNHFQIERLLNKPGLKHKP 179 Query: 181 AVLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEK 240 QVECHPYL Q +LI +CH++G+ VTAYSPLGS DR P++P LLE+P + +A K Sbjct: 180 VTNQVECHPYLTQEKLIQYCHSKGISVTAYSPLGSPDRPSAKPEDPSLLEDPKIKEIAAK 239 Query: 241 HGRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWRYIV 300 H ++ AQ+L+R+ +QR V+ IPKS+ PSRI +NIQVFDF S EEM + + N+NWR + Sbjct: 240 HEKTSAQVLIRFHIQRNVVVIPKSVTPSRIQENIQVFDFQLSDEEMATILSFNRNWRACL 299 Query: 301 PMITVDGKRVPRDAGH 316 TV+ + P DA + Sbjct: 300 LPETVNMEEYPYDAEY 315 >3RX4-A nrPDB Length = 336 Score = 297 bits (761), Expect = 4e-81, Method: Compositional matrix adjust. Identities = 158/325 (48%), Positives = 223/325 (68%), Gaps = 12/325 (3%) Query: 3 ASSVLLHTGQKMPLIGLGTWKSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALKE 62 AS +LL+ G KMP++GLGTWKS PGQV A+K A+ GYRHIDCA VY NE E+G A++E Sbjct: 22 ASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQE 81 Query: 63 SVGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGD 122 + + V REELF+ SKLW T H V+ A +KTL+DL+L+YLDLYL+HWP F+ G Sbjct: 82 KLRE-QVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGK 140 Query: 123 NPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVR--P 180 FP + G V T+ +TW A+E LV +GLVKA+G+SNFN Q++ +L+ ++ P Sbjct: 141 EFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKP 200 Query: 181 AVLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEK 240 AV Q+ECHPYL Q +LI +C ++G+ VTAYSPLGS DR W P++P LLE+P + A+A K Sbjct: 201 AVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAK 260 Query: 241 HGRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWRYIV 300 H ++ AQ+L+R+ +QR ++ IPKS+ P RI +N +VFDF S ++M L + N+NWR + Sbjct: 261 HNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWR-VC 319 Query: 301 PMITVDGKRVPRDAGHPLYPFNDPY 325 +++ H YPF++ + Sbjct: 320 ALLSC--------TSHKDYPFHEEF 336 >1C9W-A nrPDB Length = 315 Score = 297 bits (760), Expect = 4e-81, Method: Compositional matrix adjust. Identities = 156/316 (49%), Positives = 217/316 (68%), Gaps = 3/316 (0%) Query: 3 ASSVLLHTGQKMPLIGLGTWKSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALKE 62 ++ V L T KMP++GLGTW+S PGQVK A+K A+ AGYRHIDCA Y NE E+GEA++E Sbjct: 1 STFVELSTKAKMPIVGLGTWQSPPGQVKEAVKVAIDAGYRHIDCAYAYYNEHEVGEAIQE 60 Query: 63 SVGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGD 122 + KAV RE+LF+ SKLW T + ++ A +KTL DL+L+YLDLYL+HWP + G Sbjct: 61 KIKE-KAVRREDLFIVSKLWPTCFERKLLKEAFQKTLTDLKLDYLDLYLIHWPQGLQPGK 119 Query: 123 NPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVR--P 180 FPK+ G V + + W+ +E LV +GLVKALG+SNFN QI+ +L+ ++ P Sbjct: 120 ELFPKDDQGNVLTSKITFLDAWEVMEELVDEGLVKALGVSNFNHFQIERILNKPGLKHKP 179 Query: 181 AVLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEK 240 QVECHPYL Q +LI +CH++G+ VTAYSPLGS +R W P++P LLE+P + +A K Sbjct: 180 VTNQVECHPYLTQEKLIEYCHSKGITVTAYSPLGSPNRPWAKPEDPSLLEDPKIKEIAAK 239 Query: 241 HGRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWRYIV 300 H ++ AQ+L+R+ +QR V+ IPKS+ P+RI +N QVFDF S +EM + N+NWR + Sbjct: 240 HKKTSAQVLIRFHIQRNVVVIPKSVTPARIHENFQVFDFQLSDQEMATILGFNRNWRACL 299 Query: 301 PMITVDGKRVPRDAGH 316 TV+ + P DA + Sbjct: 300 LPETVNMEEYPYDAEY 315 >3O3R-A nrPDB Length = 316 Score = 295 bits (754), Expect = 3e-80, Method: Compositional matrix adjust. Identities = 156/308 (50%), Positives = 213/308 (69%), Gaps = 3/308 (0%) Query: 6 VLLHTGQKMPLIGLGTWKSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALKESVG 65 V L T KMPL+GLGTWKS PGQVK A+K A+ AGYRH DCA VY NE+E+GEA++E + Sbjct: 5 VKLRTKAKMPLVGLGTWKSPPGQVKEAVKAAIDAGYRHFDCAYVYQNESEVGEAIQEKIK 64 Query: 66 SGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPF 125 KAV RE+LF+ SKLW+T ++ A +KTL+DL+L+YLDLYL+HWP + G Sbjct: 65 E-KAVRREDLFIVSKLWSTFFEKSLMKEAFQKTLSDLKLDYLDLYLIHWPQGLQAGKEFL 123 Query: 126 PKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVR--PAVL 183 PK++ G V + + + W+ +E LV +GLVKALG+SNFN QI+ +L+ ++ P Sbjct: 124 PKDSQGKVLMSKSTFLDAWEGMEELVDQGLVKALGVSNFNHFQIERLLNKPGLKHKPVTN 183 Query: 184 QVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEKHGR 243 QVECHPYL Q +LI +CH++G+ V AYSPLGS DR + P++PV+LE P + +A KH + Sbjct: 184 QVECHPYLTQEKLIQYCHSKGIAVIAYSPLGSPDRPYAKPEDPVVLEIPKIKEIAAKHKK 243 Query: 244 SPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWRYIVPMI 303 + AQ+L+R+ VQR V IPKS+ S I +NIQVFDF S E+M + +LN+NWR + Sbjct: 244 TIAQVLIRFHVQRNVAVIPKSVTLSHIKENIQVFDFQLSEEDMAAILSLNRNWRACGLFV 303 Query: 304 TVDGKRVP 311 T D + P Sbjct: 304 TSDEEDFP 311 >4HBK-A nrPDB Length = 344 Score = 292 bits (747), Expect = 1e-79, Method: Compositional matrix adjust. Identities = 146/318 (45%), Positives = 211/318 (66%), Gaps = 13/318 (4%) Query: 8 LHTGQKMPLIGLGTWKSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALKESVGSG 67 ++ G+ +P+IGLGTW S PG+V AA+K AL GYRH+DCA VY NE EIGEAL+ ++ S Sbjct: 40 MNNGRSIPVIGLGTWNSPPGEVGAAVKKALEIGYRHLDCAYVYRNEAEIGEALENALNSL 99 Query: 68 KAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPK 127 + + RE++F+TSKLWNT PE V A +TL +L+L YLDLYL+HWP + G + FP Sbjct: 100 R-LKREDIFITSKLWNTFFRPEHVRKACEETLKNLRLNYLDLYLIHWPVPLKHGGDLFPT 158 Query: 128 NADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVRPAVLQVEC 187 +++G + D+ +++TWK +E LV +GLVK++GLSNFN RQI ++L ++PA LQ+E Sbjct: 159 DSNGQLCLDNVPHEDTWKEMEKLVDEGLVKSIGLSNFNKRQIQNILEHCRIKPANLQIEI 218 Query: 188 HPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEKHGRSPAQ 247 H +L+ + + GL VTAY+PLGS + P + LL +P VL +A +H ++PAQ Sbjct: 219 HANFPNIKLVEYAQSVGLTVTAYAPLGSPAHS---PGKVNLLTKPCVLEIAHRHKKTPAQ 275 Query: 248 ILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWRYIVPMITVDG 307 +LLR+ +QRK+I +PKS+ RI +N QVFDF S EEM +L+ + N R + Sbjct: 276 VLLRYLLQRKLIVVPKSVTFKRIEENFQVFDFQLSNEEMHELNTESLNERQFTLL----- 330 Query: 308 KRVPRDAGHPLYPFNDPY 325 + +GH YPF + Y Sbjct: 331 ----QMSGHQEYPFKEEY 344 >2FVL-A nrPDB Length = 324 Score = 281 bits (718), Expect = 4e-76, Method: Compositional matrix adjust. Identities = 142/326 (43%), Positives = 210/326 (64%), Gaps = 16/326 (4%) Query: 6 VLLHTGQKMPLIGLGTWKSEPGQVKAAI---KHALSAGYRHIDCASVYGNETEIGEALKE 62 V L+ G MP++G GT+ A+ K A+ AG+RHID A +Y NE ++G A++ Sbjct: 9 VELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVGLAIRS 68 Query: 63 SVGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGD 122 + G +V RE++F TSKLW T P+ V+PAL +L LQL+Y+DLYL+H+P A + G+ Sbjct: 69 KIADG-SVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKPGE 127 Query: 123 NPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASV--RP 180 P PK+ +G V +D+ TW+ +E GL K++G+SNFN RQ++ +L+ + +P Sbjct: 128 TPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNYRQLEMILNKPGLKYKP 187 Query: 181 AVLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSS-DRAWRHPDEPVLLEEPVVLALAE 239 QVECHPYL Q++L+ C ++ + + A+S LG+ + W P+ PVLLE+PV+ ALA+ Sbjct: 188 VCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPVLCALAK 247 Query: 240 KHGRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWRYI 299 KH R+PA I LR+Q+QR V+ + KS N RI +NIQVF+F + E+MK LD LN+N+RY+ Sbjct: 248 KHKRTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNRNYRYV 307 Query: 300 VPMITVDGKRVPRDAGHPLYPFNDPY 325 V +D HP YPF+D Y Sbjct: 308 VMDFLMD---------HPDYPFSDEY 324 >4JQA-A nrPDB Length = 331 Score = 279 bits (713), Expect = 1e-75, Method: Compositional matrix adjust. Identities = 144/326 (44%), Positives = 211/326 (64%), Gaps = 16/326 (4%) Query: 6 VLLHTGQKMPLIGLGTWK-SEPGQVKA--AIKHALSAGYRHIDCASVYGNETEIGEALKE 62 V L+ G MP++G GT+ +E + KA A+K A+ AG+ HID A VY NE ++G A++ Sbjct: 8 VKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRS 67 Query: 63 SVGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGD 122 + G +V RE++F TSKLW+ H PE V PAL ++L +LQL+Y+DLYL+H+P + + G+ Sbjct: 68 KIADG-SVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGE 126 Query: 123 NPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASV--RP 180 PK+ +G + +D+ TW+A+E GL K++G+SNFN R ++ +L+ + +P Sbjct: 127 EVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKPGLKYKP 186 Query: 181 AVLQVECHPYLAQNELIAHCHARGLEVTAYSPLGS-SDRAWRHPDEPVLLEEPVVLALAE 239 QVECHPY Q +L+ C ++ + + AYS LGS + W P+ PVLLE+PV+ ALA+ Sbjct: 187 VCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAK 246 Query: 240 KHGRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWRYI 299 KH R+PA I LR+Q+QR V+ + KS N RI QN+QVF+F + EEMK +D LN+N RY+ Sbjct: 247 KHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRYL 306 Query: 300 VPMITVDGKRVPRDAGHPLYPFNDPY 325 I AG P YPF+D Y Sbjct: 307 TLDIF---------AGPPNYPFSDEY 323 >5JH1-A nrPDB Length = 309 Score = 273 bits (699), Expect = 6e-74, Method: Compositional matrix adjust. Identities = 140/300 (46%), Positives = 198/300 (66%), Gaps = 16/300 (5%) Query: 3 ASSVLLHTGQKMPLIGLGTWKSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALKE 62 A +L+TG K+P +GLG+W+S+PG V A+ A+ AGYRHIDCA VYGNE EIG ALK+ Sbjct: 1 ARHFVLNTGAKIPSVGLGSWQSDPGVVGNAVYAAVKAGYRHIDCARVYGNEKEIGLALKK 60 Query: 63 SVGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGD 122 G V RE++F+TSKLWN H PEDV AL +L DLQLEYLDLYL+HWP+ ++G Sbjct: 61 LFEEG-VVKREDMFITSKLWNDHHAPEDVPEALNDSLNDLQLEYLDLYLIHWPFRVKKGT 119 Query: 123 NPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVRPAV 182 N P+N + + + TW A+E L G +A+G+SNF+S+++ D+L+VA V PAV Sbjct: 120 NTSPEN------FVTPDFPATWGAMEKLYDAGKARAIGVSNFSSKKLGDLLAVARVPPAV 173 Query: 183 LQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEKHG 242 QVECHP Q +L + C + G+ +TAYSPLGS W + + +L+EP+++++AEK G Sbjct: 174 DQVECHPGWQQTKLHSFCQSTGVHLTAYSPLGSPGTTWMNGN---VLKEPIIISIAEKLG 230 Query: 243 RSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPE------EMKQLDALNKNW 296 ++ AQ+ LRW +Q +PKS N RI QN+ V+D++ + E+KQ L N+ Sbjct: 231 KTSAQVALRWNIQMGHSVLPKSTNEERIKQNLDVYDWSIPDDLLAKFSEIKQARLLRGNF 290 >3G1R-A nrPDB Length = 346 Score = 272 bits (696), Expect = 1e-73, Method: Compositional matrix adjust. Identities = 141/325 (43%), Positives = 208/325 (64%), Gaps = 17/325 (5%) Query: 8 LHTGQKMPLIGLGTW---KSEP-GQVKAAIKHALSAGYRHIDCASVYGNETEIGEALKES 63 L G +P+IGLGT+ KS P G ++K A+ GYRHID A +Y NE E+GEA++E Sbjct: 32 LSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGEAIREK 91 Query: 64 VGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDN 123 + GK V RE++F KLW T H PE V P L +TL LQL+Y+DLY++ P AF+ GD Sbjct: 92 IAEGK-VRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKPGDE 150 Query: 124 PFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASV--RPA 181 +P++ +G Y ++ TW+A+E GLVK+LG+SNFN RQ++ +L+ + +P Sbjct: 151 IYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKHKPV 210 Query: 182 VLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSS-DRAWRHPDEPVLLEEPVVLALAEK 240 QVECHPY Q +L+ C + +TAYSPLG+S + W + P LL++ ++ +L ++ Sbjct: 211 SNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALLNSLGKR 270 Query: 241 HGRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWRYIV 300 + ++ AQI+LR+ +QR V+ IPKS N RI +N Q+FDF+ + EEMK ++ALNKN R++ Sbjct: 271 YNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNKNVRFVE 330 Query: 301 PMITVDGKRVPRDAGHPLYPFNDPY 325 ++ D HP YPF+D Y Sbjct: 331 LLMWRD---------HPEYPFHDEY 346 >1Q5M-A nrPDB Length = 322 Score = 268 bits (686), Expect = 2e-72, Method: Compositional matrix adjust. Identities = 137/326 (42%), Positives = 201/326 (61%), Gaps = 16/326 (4%) Query: 6 VLLHTGQKMPLIGLGTWKSE---PGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALKE 62 V L G +P++G GT+ E + A K A+ AG+RHID A Y NE E+G A++ Sbjct: 7 VALSDGHFIPVLGFGTYAPEEVPKSKAMEATKIAIDAGFRHIDSAYFYKNEKEVGLAIRS 66 Query: 63 SVGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGD 122 + G V RE++F TSKLW T H PE V P+L +L +LQL+Y+DLY++H+P A + G Sbjct: 67 KIADG-TVKREDIFYTSKLWCTFHRPELVRPSLEDSLKNLQLDYVDLYIIHFPTALKPGV 125 Query: 123 NPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASV--RP 180 P + G +D+ TW+A+E GL K++G+SNFN RQ++ +L+ + +P Sbjct: 126 EIIPTDEHGKAIFDTVDICATWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKP 185 Query: 181 AVLQVECHPYLAQNELIAHCHARGLEVTAYSPLGS-SDRAWRHPDEPVLLEEPVVLALAE 239 QVECHPYL Q +L+ C ++G+ + AYS LGS + W PVLLE+P++ ALA+ Sbjct: 186 VCNQVECHPYLNQGKLLEFCKSKGIVLVAYSALGSHREPEWVDQSAPVLLEDPLIGALAK 245 Query: 240 KHGRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWRYI 299 KH ++PA I LR+Q+QR ++ + KS RI +NIQVF+F E+MK +D+LN+N+RY+ Sbjct: 246 KHQQTPALIALRYQLQRGIVVLAKSFTEKRIKENIQVFEFQLPSEDMKVIDSLNRNFRYV 305 Query: 300 VPMITVDGKRVPRDAGHPLYPFNDPY 325 + GHP YPF+D Y Sbjct: 306 TADFAI---------GHPNYPFSDEY 322 >5JM5-A nrPDB Length = 332 Score = 266 bits (679), Expect = 1e-71, Method: Compositional matrix adjust. Identities = 139/326 (42%), Positives = 204/326 (62%), Gaps = 16/326 (4%) Query: 6 VLLHTGQKMPLIGLGTWKS-EPGQVKA--AIKHALSAGYRHIDCASVYGNETEIGEALKE 62 V L+ G MP++G GT+ E + KA K A+ AG+RHID A +Y NE ++G A++ Sbjct: 8 VKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQVGLAIRS 67 Query: 63 SVGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGD 122 + G +V RE++F TSKLW+T H PE V PAL +L QL+Y+DLYL+H P + + G+ Sbjct: 68 KIADG-SVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLKPGE 126 Query: 123 NPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASV--RP 180 P + +G V +D TW+A+E GL K++G+SNFN RQ++ +L+ + +P Sbjct: 127 ELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKP 186 Query: 181 AVLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSS-DRAWRHPDEPVLLEEPVVLALAE 239 QVECHPY +++L+ C ++ + + AYS LGS D+ W P+ PVLLE+PV+ ALA+ Sbjct: 187 VCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPVLCALAK 246 Query: 240 KHGRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWRYI 299 KH R+PA I LR+Q+QR V+ + KS N RI QN+QVF+F + E+MK +D L++N Y Sbjct: 247 KHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLDRNLHYF 306 Query: 300 VPMITVDGKRVPRDAGHPLYPFNDPY 325 A HP YP++D Y Sbjct: 307 ---------NSDSFASHPNYPYSDEY 323 >5UXF-A nrPDB Length = 342 Score = 261 bits (668), Expect = 2e-70, Method: Compositional matrix adjust. Identities = 137/327 (41%), Positives = 201/327 (61%), Gaps = 16/327 (4%) Query: 5 SVLLHTGQKMPLIGLGTWKSE---PGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALK 61 V L+ G +P +G GT+K + + A AL GYRH+D A Y E EIG+A++ Sbjct: 26 CVKLNDGHLIPALGFGTYKPKEVPKSKSLEAACLALDVGYRHVDTAYAYQVEEEIGQAIQ 85 Query: 62 ESVGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERG 121 ++ +G V RE+LFVT+KLW T PE V+PAL K+L LQL+Y+DLY+MH+P + G Sbjct: 86 SAIAAG-VVKREDLFVTTKLWCTCFRPELVKPALEKSLKKLQLDYVDLYIMHYPVPMKSG 144 Query: 122 DNPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASV--R 179 DN FP N G D+ + +TW+ LE GLVK++G+SNFN RQ++ +L+ + + Sbjct: 145 DNDFPVNEQGKSLLDTVDFCDTWERLEECKDAGLVKSIGVSNFNHRQLERILNKPGLKYK 204 Query: 180 PAVLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSD-RAWRHPDEPVLLEEPVVLALA 238 P QVECH YL Q +L+ +C ++ + + AY LG+ + W + PVLL +PV+ +A Sbjct: 205 PVCNQVECHLYLNQRKLLDYCESKDIVLVAYGALGTQRYKEWVDQNSPVLLNDPVLCDVA 264 Query: 239 EKHGRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWRY 298 +K+ RSPA I LR+ +QR ++ + +S + + +N+QVF F SPE+MK LD LNKN+RY Sbjct: 265 KKNKRSPALIALRYLIQRGIVPLAQSFKENEMRENLQVFGFQLSPEDMKTLDGLNKNFRY 324 Query: 299 IVPMITVDGKRVPRDAGHPLYPFNDPY 325 + VD HP YPF + Y Sbjct: 325 LPAEFLVD---------HPEYPFVEEY 342 >2HE8-A nrPDB Length = 323 Score = 253 bits (646), Expect = 9e-68, Method: Compositional matrix adjust. Identities = 131/327 (40%), Positives = 197/327 (60%), Gaps = 16/327 (4%) Query: 5 SVLLHTGQKMPLIGLGT---WKSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALK 61 V+L+ G +P++G GT + + K K A+ AG+ H D ASVY E +GEA++ Sbjct: 7 CVILNDGNFIPVLGFGTALPLECPKSKAKELTKIAIDAGFHHFDSASVYNTEDHVGEAIR 66 Query: 62 ESVGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERG 121 + G V RE++F TSK+W T HPE V +L ++L LQ +Y+DLYL+H+P A + G Sbjct: 67 SKIADG-TVRREDIFYTSKVWCTSLHPELVRASLERSLQKLQFDYVDLYLIHYPMALKPG 125 Query: 122 DNPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASV--R 179 + FP + G + +D TW+A+E GL K++G+SNFN RQ++ +L+ + + Sbjct: 126 EENFPVDEHGKLIFDRVDLCATWEAMEKCKDAGLTKSIGVSNFNYRQLEMILNKPGLKYK 185 Query: 180 PAVLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDR-AWRHPDEPVLLEEPVVLALA 238 P QVECHPYL Q +L+ C ++ + + AY LG+ W + PVLL+EPV+ ++A Sbjct: 186 PVCNQVECHPYLNQMKLLDFCKSKDIVLVAYGVLGTQRYGGWVDQNSPVLLDEPVLGSMA 245 Query: 239 EKHGRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWRY 298 +K+ R+PA I LR+Q+QR ++ + S+ RI +N+QVF+F S E+MK LD LN+N RY Sbjct: 246 KKYNRTPALIALRYQLQRGIVVLNTSLKEERIKENMQVFEFQLSSEDMKVLDGLNRNMRY 305 Query: 299 IVPMITVDGKRVPRDAGHPLYPFNDPY 325 I I GHP +PF D Y Sbjct: 306 IPAAIF---------KGHPNWPFLDEY 323 >3H7U-A nrPDB Length = 335 Score = 253 bits (645), Expect = 1e-67, Method: Compositional matrix adjust. Identities = 131/280 (46%), Positives = 180/280 (64%), Gaps = 12/280 (4%) Query: 8 LHTGQKMPLIGLGTWKSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALKESVGSG 67 L+TG K P +GLGTW++ PG V A+ A+ GYRHIDCA +YGNE EIG LK+ + Sbjct: 30 LNTGAKFPSVGLGTWQASPGLVGDAVAAAVKIGYRHIDCAQIYGNEKEIGAVLKK-LFED 88 Query: 68 KAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPF-P 126 + V RE+LF+TSKLW T H P+DV AL +TL DLQLEY+DLYL+HWP ++G P Sbjct: 89 RVVKREDLFITSKLWCTDHDPQDVPEALNRTLKDLQLEYVDLYLIHWPARIKKGSVGIKP 148 Query: 127 KNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVRPAVLQVE 186 +N TWKA+E L G +A+G+SNF+++++ D+L +A V PAV QVE Sbjct: 149 EN------LLPVDIPSTWKAMEALYDSGKARAIGVSNFSTKKLADLLELARVPPAVNQVE 202 Query: 187 CHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEKHGRSPA 246 CHP Q +L C ++G+ ++AYSPLGS W D +L+ P++ +AEK G+SPA Sbjct: 203 CHPSWRQTKLQEFCKSKGVHLSAYSPLGSPGTTWLKSD---VLKNPILNMVAEKLGKSPA 259 Query: 247 QILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEM 286 Q+ LRW +Q +PKS N RI +N VFD++ P+ M Sbjct: 260 QVALRWGLQMGHSVLPKSTNEGRIKENFNVFDWSI-PDYM 298 >5ZCM-A nrPDB Length = 341 Score = 252 bits (643), Expect = 2e-67, Method: Compositional matrix adjust. Identities = 133/321 (41%), Positives = 197/321 (61%), Gaps = 19/321 (5%) Query: 5 SVLLHTGQKMPLIGLGTWKSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALKESV 64 S+ L++G +MPL+G G WK + + +A+ GYR D A YGN EIGE + ++ Sbjct: 23 SIKLNSGYEMPLVGFGCWKVDNATCADTVYNAIKVGYRLFDAAMDYGNCKEIGEGINRAL 82 Query: 65 GSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAF-----E 119 G V R+ELF+TSKLWN+ H P++VE AL+K L+D++L+Y+DL+L+H+P AF E Sbjct: 83 DEG-LVARDELFITSKLWNSYHDPKNVELALKKVLSDMKLDYIDLFLIHFPIAFKFVPFE 141 Query: 120 RGDNPFPKNADGTVRYDSTHYK-----ETWKALEVLVAKGLVKALGLSNFNSRQIDDVLS 174 P DG D+ HY+ ETWKA+E L G K++G+SNF++ I D+L Sbjct: 142 EKYPPAFYCGDG----DNFHYEDVPLLETWKAMEKLTKGGKAKSIGISNFSAALIYDLLR 197 Query: 175 VASVRPAVLQVECHPYLAQNELIAHCHARGLEVTAYSPLG-SSDRAWRHP---DEPVLLE 230 A ++PAVLQ+E HPYL Q LI + ++G+ +TAYS G S +H D P L E Sbjct: 198 GAEIKPAVLQIEHHPYLQQPRLIEYVQSQGIAITAYSSFGPQSFLELKHSKALDTPTLFE 257 Query: 231 EPVVLALAEKHGRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLD 290 + ++A+K+ ++PAQ+LLRW QR + IPKS NP R+LQN++V DF S E+ ++ Sbjct: 258 HKTITSIADKYKKTPAQVLLRWASQRDIAIIPKSNNPDRLLQNLEVNDFNLSKEDFDEIS 317 Query: 291 ALNKNWRYIVPMITVDGKRVP 311 L+++ R+ P R+P Sbjct: 318 KLDQDLRFNNPWDWDTKNRIP 338 >1AFS-A nrPDB Length = 323 Score = 249 bits (636), Expect = 1e-66, Method: Compositional matrix adjust. Identities = 128/324 (39%), Positives = 200/324 (61%), Gaps = 16/324 (4%) Query: 6 VLLHTGQKMPLIGLGTW---KSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALKE 62 V L+ G +P++G GT K +V A K A+ G+RH D A +Y E E+G+A++ Sbjct: 8 VALNDGNFIPVLGFGTTVPEKVAKDEVIKATKIAIDNGFRHFDSAYLYEVEEEVGQAIRS 67 Query: 63 SVGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGD 122 + G V RE++F TSKLW+T H PE V L KTL QL+Y+DLY++H+P A + GD Sbjct: 68 KIEDG-TVKREDIFYTSKLWSTFHRPELVRTCLEKTLKSTQLDYVDLYIIHFPMALQPGD 126 Query: 123 NPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASV--RP 180 FP++ G + +++ +TW+A+E GL K++G+SNFN RQ++ +L+ + +P Sbjct: 127 IFFPRDEHGKLLFETVDICDTWEAMEKCKDAGLAKSIGVSNFNCRQLERILNKPGLKYKP 186 Query: 181 AVLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSS-DRAWRHPDEPVLLEEPVVLALAE 239 QVECH YL Q++++ +C ++ + + +Y LGSS D+ W PVLL++PV+ A+A+ Sbjct: 187 VCNQVECHLYLNQSKMLDYCKSKDIILVSYCTLGSSRDKTWVDQKSPVLLDDPVLCAIAK 246 Query: 240 KHGRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWRYI 299 K+ ++PA + LR+Q+QR V+ + +S N RI + QVF+F + E+MK LD LN+N+RY Sbjct: 247 KYKQTPALVALRYQLQRGVVPLIRSFNAKRIKELTQVFEFQLASEDMKALDGLNRNFRYN 306 Query: 300 VPMITVDGKRVPRDAGHPLYPFND 323 D HP +PF D Sbjct: 307 NAKYFDD---------HPNHPFTD 321 >3H7R-A nrPDB Length = 331 Score = 240 bits (613), Expect = 6e-64, Method: Compositional matrix adjust. Identities = 128/279 (45%), Positives = 184/279 (65%), Gaps = 14/279 (5%) Query: 8 LHTGQKMPLIGLGTWKSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALKESVGSG 67 L+TG K+P +GLGT+ V AI+ A+ GYRHIDCAS+YGNE EIG LK+ +G G Sbjct: 30 LNTGAKLPCVGLGTY----AMVATAIEQAIKIGYRHIDCASIYGNEKEIGGVLKKLIGDG 85 Query: 68 KAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPK 127 V REELF+TSKLW+ H PEDV AL KTL DLQ++Y+DLYL+HWP + ++ ++ P Sbjct: 86 -FVKREELFITSKLWSNDHLPEDVPKALEKTLQDLQIDYVDLYLIHWPASLKK-ESLMP- 142 Query: 128 NADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVRPAVLQVEC 187 + + D T TWKA+E L G +A+G+SNF+S+++ D+L+VA V PAV QVEC Sbjct: 143 TPEMLTKPDIT---STWKAMEALYDSGKARAIGVSNFSSKKLTDLLNVARVTPAVNQVEC 199 Query: 188 HPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEKHGRSPAQ 247 HP Q L C ++G+ ++ YSPLGS + +L+ P+V +AEK G++ AQ Sbjct: 200 HPVWQQQGLHELCKSKGVHLSGYSPLGSQSKGEVRLK---VLQNPIVTEVAEKLGKTTAQ 256 Query: 248 ILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEM 286 + LRW +Q +PKS + +R+ +N+ VFD++ PE++ Sbjct: 257 VALRWGLQTGHSVLPKSSSGARLKENLDVFDWSI-PEDL 294 >3WCZ-A nrPDB Length = 308 Score = 232 bits (592), Expect = 1e-61, Method: Compositional matrix adjust. Identities = 121/305 (39%), Positives = 185/305 (60%), Gaps = 18/305 (5%) Query: 1 MTASSVLLHTGQKMPLIGLGTWKSEP------GQVKAAIKHALSAGYRHIDCASVYGNET 54 + A + L+ G +P++ LGT + +V+ A+ A+ AGYRHID A+VY +E Sbjct: 3 VQAPCIQLNDGNTIPIVALGTGRGTAKESDSIDEVRQAVYWAIEAGYRHIDTAAVYQDEE 62 Query: 55 EIGEALKESVGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHW 114 ++G+ + E++ +G V REELFVT+KLWN KH + V PAL+++L L L+Y+DLYL+H+ Sbjct: 63 QVGQGIAEAIANG-LVTREELFVTTKLWNDKHARDQVVPALQESLKKLGLDYIDLYLIHF 121 Query: 115 PYAFERGDNPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLS 174 P A + D+P D+ Y ETW+ ++ GL +++G+SNFN+ QI ++S Sbjct: 122 PIATKPDDSP-----------DNIDYLETWQGMQDARQLGLARSIGVSNFNATQITRLVS 170 Query: 175 VASVRPAVLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVV 234 + +RP + Q+E +P Q L+AHC + G+ V AYSP G + P ++P + Sbjct: 171 NSYIRPVINQIEVNPTNTQEPLVAHCQSLGIAVMAYSPFGFVVSRGQTGAPPPRSDDPTL 230 Query: 235 LALAEKHGRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNK 294 ALA K+ +S QILLR+ + R +I IPKS N RI QNI +FDF + EE+ ++ NK Sbjct: 231 TALANKYRKSVGQILLRYLIDRGLIPIPKSTNKQRIAQNIDLFDFQLTFEEVAAINQFNK 290 Query: 295 NWRYI 299 N R I Sbjct: 291 NHRVI 295 >1K8C-A nrPDB Length = 322 Score = 231 bits (588), Expect = 5e-61, Method: Compositional matrix adjust. Identities = 129/313 (41%), Positives = 181/313 (57%), Gaps = 13/313 (4%) Query: 1 MTAS--SVLLHTGQKMPLIGLGTWKSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGE 58 M+AS + L +G MP IG G WK + A+ AGYR D A YGNE E+G+ Sbjct: 1 MSASIPDIKLSSGHLMPSIGFGCWKLANATAGEQVYQAIKAGYRLFDGAEDYGNEKEVGD 60 Query: 59 ALKESVGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAF 118 +K ++ G V REE+F+TSKLWN H P++VE AL KTLADL+++Y+DL+L+H+P AF Sbjct: 61 GVKRAIDEG-LVKREEIFLTSKLWNNYHDPKNVETALNKTLADLKVDYVDLFLIHFPIAF 119 Query: 119 -----ERGDNPFPKNADGT-VRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDV 172 E P DG Y+ ETWKALE LVA G +K++G+SNF + D+ Sbjct: 120 KFVPIEEKYPPGFYCGDGNNFVYEDVPILETWKALEKLVAAGKIKSIGVSNFPGALLLDL 179 Query: 173 LSVASVRPAVLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSD----RAWRHPDEPVL 228 L A+++PAVLQVE HPYL Q +LI G+ +TAYS G R + P L Sbjct: 180 LRGATIKPAVLQVEHHPYLQQPKLIEFAQKAGVTITAYSSFGPQSFVEMNQGRALNTPTL 239 Query: 229 LEEPVVLALAEKHGRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQ 288 + A+A K+ ++PA++LLRW QR + IPKS P R++QN F + E+ ++ Sbjct: 240 FAHDTIKAIAAKYNKTPAEVLLRWAAQRGIAVIPKSNLPERLVQNRSFNTFDLTKEDFEE 299 Query: 289 LDALNKNWRYIVP 301 + L+ R+ P Sbjct: 300 IAKLDIGLRFNDP 312 >5Z6T-A nrPDB Length = 343 Score = 229 bits (585), Expect = 1e-60, Method: Compositional matrix adjust. Identities = 124/307 (40%), Positives = 175/307 (57%), Gaps = 11/307 (3%) Query: 5 SVLLHTGQKMPLIGLGTWKSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALKESV 64 S+ L++G MP +G G WK + I A+ GYR D A Y NE +G +K+++ Sbjct: 28 SIKLNSGYDMPAVGFGCWKVDVDTCSEQIYRAIKTGYRLFDGAEDYANEKLVGAGVKKAI 87 Query: 65 GSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAF------ 118 G V RE+LF+TSKLWN HHP++VE AL +TL+DLQ++Y+DL+L+H+P F Sbjct: 88 DEG-IVKREDLFLTSKLWNNYHHPDNVEKALNRTLSDLQVDYVDLFLIHFPVTFKFVPLE 146 Query: 119 ERGDNPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASV 178 E+ F Y+ ETWKALE LV G ++++G+SNF + D+L A++ Sbjct: 147 EKYPPGFYCGKGDNFDYEDVPILETWKALEKLVKAGKIRSIGVSNFPGALLLDLLRGATI 206 Query: 179 RPAVLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSD----RAWRHPDEPVLLEEPVV 234 +P+VLQVE HPYL Q LI +RG+ VTAYS G R + L E + Sbjct: 207 KPSVLQVEHHPYLQQPRLIEFAQSRGIAVTAYSSFGPQSFVELNQGRALNTSPLFENETI 266 Query: 235 LALAEKHGRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNK 294 A+A KHG+SPAQ+LLRW QR + IPKS R+L+N V F ++ + L+ Sbjct: 267 KAIAAKHGKSPAQVLLRWSSQRGIAIIPKSNTVPRLLENKDVNSFDLDEQDFADIAKLDI 326 Query: 295 NWRYIVP 301 N R+ P Sbjct: 327 NLRFNDP 333 >4F40-A nrPDB Length = 288 Score = 228 bits (580), Expect = 3e-60, Method: Compositional matrix adjust. Identities = 119/294 (40%), Positives = 176/294 (59%), Gaps = 28/294 (9%) Query: 6 VLLHTGQKMPLIGLGTWKSEPGQV-KAAIKHALSAGYRHIDCASVYGNETEIGEALKESV 64 V L G KMP GLG W+S G+V + A+K AL AGYRHID A++Y NE +G L+ S Sbjct: 13 VTLSNGVKMPQFGLGVWQSPAGEVTENAVKWALCAGYRHIDTAAIYKNEESVGAGLRAS- 71 Query: 65 GSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNP 124 VPRE++F+T+KLWNT+ E A ++ L ++Y+DLYL+HWP RG + Sbjct: 72 ----GVPREDVFITTKLWNTEQGYESTLAAFEESRQKLGVDYIDLYLIHWP----RGKDI 123 Query: 125 FPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVRPAVLQ 184 K + Y ++W+A E L + V+A+G+SNF+ ++DVL++ +V P V Q Sbjct: 124 LSK--------EGKKYLDSWRAFEQLYKEKKVRAIGVSNFHIHHLEDVLAMCTVTPMVNQ 175 Query: 185 VECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEKHGRS 244 VE HP Q +L A C A+ ++V A+SPLG LL P++ A+ K+ ++ Sbjct: 176 VELHPLNNQADLRAFCDAKQIKVEAWSPLGQGK----------LLSNPILSAIGAKYNKT 225 Query: 245 PAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWRY 298 AQ++LRW +Q+ +I IPKS++ RI +N +FDF E++ +DALN N RY Sbjct: 226 AAQVILRWNIQKNLITIPKSVHRERIEENADIFDFELGAEDVMSIDALNTNSRY 279 >3KRB-A nrPDB Length = 334 Score = 222 bits (565), Expect = 2e-58, Method: Compositional matrix adjust. Identities = 122/304 (40%), Positives = 179/304 (58%), Gaps = 12/304 (3%) Query: 12 QKMPLIGLGTWKSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEAL-KESVGSGKAV 70 Q P +G GTW++ P V+ A++ AL GYRHIDCA VY NE IG A K + + Sbjct: 23 QYPPRLGFGTWQAPPEAVQTAVETALMTGYRHIDCAYVYQNEEAIGRAFGKIFKDASSGI 82 Query: 71 PREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGD--NPFPKN 128 RE++++TSKLWN H PE V +KT++DLQ++YLDL+L+HWP AF R D + FPK+ Sbjct: 83 KREDVWITSKLWNYNHRPELVREQCKKTMSDLQVDYLDLFLVHWPLAFVRNDVGDLFPKD 142 Query: 129 ADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVRPAVLQVECH 188 A+G + +TW+A+E LV +GLVK +G+SN+ + D+L+ A ++P V Q+E H Sbjct: 143 AEGRAMLEKVPLADTWRAMEQLVEEGLVKHIGVSNYTVPLLADLLNYAKIKPLVNQIEIH 202 Query: 189 PYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPD---EPVLLEEPVVLALAEKHGRSP 245 P+ + + C G+ VTAYSP+G S R P + V+LE + A+A+ G SP Sbjct: 203 PWHPNDATVKFCLDNGIGVTAYSPMGGSYADPRDPSGTQKNVILECKTLKAIADAKGTSP 262 Query: 246 AQILLRWQVQR----KVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDA--LNKNWRYI 299 + L W V++ IPKS P+RI N + + S ++M ++ LNK R+ Sbjct: 263 HCVALAWHVKKWNTSMYSVIPKSQTPARIEANFKCTEVQLSDDDMDAINNIHLNKRIRFC 322 Query: 300 VPMI 303 P I Sbjct: 323 DPAI 326 >4GIE-A nrPDB Length = 290 Score = 219 bits (558), Expect = 1e-57, Method: Compositional matrix adjust. Identities = 115/295 (38%), Positives = 170/295 (57%), Gaps = 33/295 (11%) Query: 4 SSVLLHTGQKMPLIGLGTWKSEPGQVKA-AIKHALSAGYRHIDCASVYGNETEIGEALKE 62 + V LH +MP +GLG W+++ G A A++ A+ AGYRHID A +Y NE +G+ ++E Sbjct: 14 NCVTLHNSVRMPQLGLGVWRAQDGAETANAVRWAIEAGYRHIDTAYIYSNERGVGQGIRE 73 Query: 63 SVGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGD 122 S VPREE++VT+K+WN+ E A ++ L LEY+DLYL+HWP G Sbjct: 74 S-----GVPREEVWVTTKVWNSDQGYEKTLAAFERSRELLGLEYIDLYLIHWP-----GK 123 Query: 123 NPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVRPAV 182 F +TWKALE L + V+A+G+SNF + ++ +RP V Sbjct: 124 KKFV---------------DTWKALEKLYEEKKVRAIGVSNFEPHHLTELFKSCKIRPMV 168 Query: 183 LQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEKHG 242 QVE HP Q L C + +TA+SPLGS + E +L+ V+ +A+KH Sbjct: 169 NQVELHPLFQQRTLREFCKQHNIAITAWSPLGSGE-------EAGILKNHVLGEIAKKHN 221 Query: 243 RSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWR 297 +SPAQ+++RW +Q ++ IPKS N RI +N V+DF + EEM+Q+D LN++ R Sbjct: 222 KSPAQVVIRWDIQHGIVTIPKSTNKGRIQENFNVWDFKLTEEEMRQIDELNEDKR 276 >2BGQ-A nrPDB Length = 344 Score = 217 bits (553), Expect = 5e-57, Method: Compositional matrix adjust. Identities = 114/294 (38%), Positives = 171/294 (58%), Gaps = 14/294 (4%) Query: 7 LLHTGQKMPLIGLGTWKSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALKESVGS 66 +L +G MP +GLGTW++ + AGYRH+D A+ YG E E+G+ LK ++ + Sbjct: 41 VLKSGHAMPAVGLGTWRAGSDTAHSVRTAITEAGYRHVDTAAEYGVEKEVGKGLKAAMEA 100 Query: 67 GKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFP 126 G + R++LFVTSK+W T PE V PAL TL DLQL+Y+DLY +HWP+ + G + P Sbjct: 101 G--IDRKDLFVTSKIWCTNLAPERVRPALENTLKDLQLDYIDLYHIHWPFRLKDGAH-MP 157 Query: 127 KNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVRPAVLQVE 186 A + +D + WK +E LV GLVK +G+ N+ +++ +L A + PAV Q+E Sbjct: 158 PEAGEVLEFD---MEGVWKEMENLVKDGLVKDIGVCNYTVTKLNRLLRSAKIPPAVCQME 214 Query: 187 CHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEKHGRSPA 246 HP +++ C G+ +TAYSPLGSS++ H +PVV +A K ++P Sbjct: 215 MHPGWKNDKIFEACKKHGIHITAYSPLGSSEKNLAH--------DPVVEKVANKLNKTPG 266 Query: 247 QILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWRYIV 300 Q+L++W +QR IPKS RI +NIQVF + E+ K L ++ R + Sbjct: 267 QVLIKWALQRGTSVIPKSSKDERIKENIQVFGWEIPEEDFKVLCSIKDEKRVLT 320 >1VBJ-A nrPDB Length = 281 Score = 214 bits (544), Expect = 5e-56, Method: Compositional matrix adjust. Identities = 115/295 (38%), Positives = 167/295 (56%), Gaps = 36/295 (12%) Query: 5 SVLLHTGQKMPLIGLGTWKSEPG-QVKAAIKHALSAGYRHIDCASVYGNETEIGEALKES 63 S+ L G MP++G G WK + G + + A A+ +GYRHID A++Y NE G A+ Sbjct: 11 SLKLSNGVMMPVLGFGMWKLQDGNEAETATMWAIKSGYRHIDTAAIYKNEESAGRAIASC 70 Query: 64 VGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDN 123 VPREELFVT+KLWN+ E A K++ L LEY+DLYL+HWP G + Sbjct: 71 -----GVPREELFVTTKLWNSDQGYESTLSAFEKSIKKLGLEYVDLYLIHWP-----GKD 120 Query: 124 PFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVRPAVL 183 F +TWKA E L A V+A+G+SNF+ I+++L V P V Sbjct: 121 KFI---------------DTWKAFEKLYADKKVRAIGVSNFHEHHIEELLKHCKVAPMVN 165 Query: 184 QVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEKHGR 243 Q+E HP L Q L +C ++ + VTA+SPLG L+E+ + A+ K+G+ Sbjct: 166 QIELHPLLNQKALCEYCKSKNIAVTAWSPLGQGH----------LVEDARLKAIGGKYGK 215 Query: 244 SPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWRY 298 + AQ++LRW++Q VI IPKS N +RI +N +FDF + E+++ +D +N RY Sbjct: 216 TAAQVMLRWEIQAGVITIPKSGNEARIKENGNIFDFELTAEDIQVIDGMNAGHRY 270 >1QWK-A nrPDB Length = 317 Score = 212 bits (539), Expect = 2e-55, Method: Compositional matrix adjust. Identities = 120/306 (39%), Positives = 177/306 (57%), Gaps = 20/306 (6%) Query: 4 SSVLLHTGQKMPLIGLGTWKSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALKES 63 +S+ L G +MP+IGLGTW+S P +V A+K A+ AGYR ID ASVY NE IG A+KE Sbjct: 6 ASIKLSNGVEMPVIGLGTWQSSPAEVITAVKTAVKAGYRLIDTASVYQNEEAIGTAIKEL 65 Query: 64 VGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDN 123 + G V REELF+T+K W + P +E LR++L LQLEY+DLYL H P AF Sbjct: 66 LEEG-VVKREELFITTKAWTHELAPGKLEGGLRESLKKLQLEYVDLYLAHMPAAFN---- 120 Query: 124 PFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVRPAVL 183 D + ++ ++ W+ + + GL KA+G+SN+N+ QI L++ Sbjct: 121 ------DDMSEHIASPVEDVWRQFDAVYKAGLAKAVGVSNWNNDQISRALALGLTPVHNS 174 Query: 184 QVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRA-WRHPD--------EPVLLEEPVV 234 QVE H Y Q++ + C + VT+Y+ LGS R + P P L++ V Sbjct: 175 QVELHLYFPQHDHVDFCKKHNISVTSYATLGSPGRVNFTLPTGQKLDWAPAPSDLQDQNV 234 Query: 235 LALAEKHGRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNK 294 LALAEK ++PAQ+LLR+ + R +PKSI +RI +N +VFDF+ + E++ +L+ Sbjct: 235 LALAEKTHKTPAQVLLRYALDRGCAILPKSIQENRIKENFEVFDFSLTEEDIAKLEESKN 294 Query: 295 NWRYIV 300 + R + Sbjct: 295 SQRLFL 300 >3D3F-A nrPDB Length = 275 Score = 207 bits (526), Expect = 6e-54, Method: Compositional matrix adjust. Identities = 122/295 (41%), Positives = 171/295 (57%), Gaps = 36/295 (12%) Query: 4 SSVLLHTGQKMPLIGLGTWKSEPG-QVKAAIKHALSAGYRHIDCASVYGNETEIGEALKE 62 +V LH G +MP GLG +K E G + ++K A+ GYR ID A++Y NE +G +KE Sbjct: 6 DTVKLHNGVEMPWFGLGVFKVENGNEATESVKAAIKNGYRSIDTAAIYKNEEGVGIGIKE 65 Query: 63 SVGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGD 122 S V REELF+TSK+WN E A K+L LQL+YLDLYL+HWP Sbjct: 66 S-----GVAREELFITSKVWNEDQGYETTLAAFEKSLERLQLDYLDLYLIHWP------- 113 Query: 123 NPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVRPAV 182 YK+TW+ALE L G ++A+G+SNF ++++L A ++P V Sbjct: 114 -------------GKDKYKDTWRALEKLYKDGKIRAIGVSNFQVHHLEELLKDAEIKPMV 160 Query: 183 LQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEKHG 242 QVE HP L Q EL +C +G+++ A+SPL LL+ V+ +AEKH Sbjct: 161 NQVEFHPRLTQKELRDYCKGQGIQLEAWSPLMQGQ----------LLDNEVLTQIAEKHN 210 Query: 243 RSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWR 297 +S AQ++LRW +Q V+ IPKSI RI++N +FDF S E+M ++DALNK+ R Sbjct: 211 KSVAQVILRWDLQHGVVTIPKSIKEHRIIENADIFDFELSQEDMDKIDALNKDER 265 >1MZR-A nrPDB Length = 296 Score = 194 bits (493), Expect = 4e-50, Method: Compositional matrix adjust. Identities = 104/295 (35%), Positives = 162/295 (54%), Gaps = 35/295 (11%) Query: 4 SSVLLHTGQKMPLIGLGTWKSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALKES 63 + + L G MP +GLG W++ +V AI+ AL GYR ID A+ Y NE +G+ALK + Sbjct: 26 TVIKLQDGNVMPQLGLGVWQASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGKALKNA 85 Query: 64 VGSGKAVPREELFVTSKLWNTKH-HPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGD 122 +V REELF+T+KLWN H P + AL +L LQL+Y+DLYLMHWP Sbjct: 86 -----SVNREELFITTKLWNDDHKRPRE---ALLDSLKKLQLDYIDLYLMHWPVPA---- 133 Query: 123 NPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVRPAV 182 HY E WK + L +GL+K++G+ NF + ++ V P + Sbjct: 134 --------------IDHYVEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVI 179 Query: 183 LQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEKHG 242 Q+E HP + Q +L A ++ ++SPL + + ++ V+ LA+K+G Sbjct: 180 NQIELHPLMQQRQLHAWNATHKIQTESWSPLAQGGKG--------VFDQKVIRDLADKYG 231 Query: 243 RSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWR 297 ++PAQI++RW + ++ IPKS+ PSRI +N V+DF +E+ ++ L++ R Sbjct: 232 KTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQGKR 286 >1VP5-A nrPDB Length = 298 Score = 184 bits (467), Expect = 4e-47, Method: Compositional matrix adjust. Identities = 99/295 (33%), Positives = 163/295 (55%), Gaps = 30/295 (10%) Query: 1 MTASSVLLHTGQKMPLIGLGTWKSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEAL 60 M V L+ G +MP++G G ++ P + + + A+ GYR ID A+ Y NE +G A+ Sbjct: 13 MQVPKVTLNNGVEMPILGYGVFQIPPEKTEECVYEAIKVGYRLIDTAASYMNEEGVGRAI 72 Query: 61 KESVGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFER 120 K ++ G V REELFVT+KLW + E + A K+L LQLEY+DLYL+H P+ Sbjct: 73 KRAIDEG-IVRREELFVTTKLWVSDVGYESTKKAFEKSLKKLQLEYIDLYLIHQPF---- 127 Query: 121 GDNPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVRP 180 GD H WKA+E + GLV+A+G+SNF ++ D++ + P Sbjct: 128 GD---------------VHC--AWKAMEEMYKDGLVRAIGVSNFYPDRLMDLMVHHEIVP 170 Query: 181 AVLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEK 240 AV Q+E HP+ + E I ++ A+ P + + + V+ ++AEK Sbjct: 171 AVNQIEIHPFYQRQEEIEFMRNYNIQPEAWGPFAEGRKN--------IFQNGVLRSIAEK 222 Query: 241 HGRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKN 295 +G++ AQ++LRW Q+ ++ IPK++ R+ +NI +FDF + E+M+++ L++ Sbjct: 223 YGKTVAQVILRWLTQKGIVAIPKTVRRERMKENISIFDFELTQEDMEKIATLDEG 277 >4MHB-A nrPDB Length = 297 Score = 179 bits (454), Expect = 1e-45, Method: Compositional matrix adjust. Identities = 96/290 (33%), Positives = 159/290 (54%), Gaps = 35/290 (12%) Query: 5 SVLLHTGQKMPLIGLGTWK-SEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALKES 63 +V L+ G MPL+G G ++ + + + A+ A+ GYR ID A+ Y NET++G ALK S Sbjct: 17 TVKLNNGIAMPLLGFGVFQMTNTAECERAVIDAIETGYRLIDTAASYQNETQVGNALKLS 76 Query: 64 VGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDN 123 + R+ELF+T+KLW + E + ++L LQL+Y+DLYL+H PY G Sbjct: 77 -----GIARDELFITTKLWLQDTYYEGAKAQFERSLNRLQLDYVDLYLIHQPYGDVHG-- 129 Query: 124 PFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVRPAVL 183 W+A+E L G ++A+G+SNF+ ++ D+++ + PAV Sbjct: 130 -------------------AWRAMEELHQAGKIRAIGVSNFHPDRLADLMAFNKIIPAVN 170 Query: 184 QVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEKHGR 243 Q+E +P+ Q + +RG++ A++P L + PV+ A+ EK+G+ Sbjct: 171 QIEVNPFNQQLHAVPWMQSRGIQPEAWAPFAEGRNG--------LFQNPVLTAIGEKYGK 222 Query: 244 SPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALN 293 S Q++LRW QR ++ + KS+ R+ +NI + DF S E+M Q+ AL+ Sbjct: 223 SVGQVVLRWIFQRGIVSLAKSVRKGRMEENINILDFELSAEDMLQIAALD 272 >1A80-A nrPDB Length = 277 Score = 172 bits (436), Expect = 2e-43, Method: Compositional matrix adjust. Identities = 98/292 (33%), Positives = 159/292 (54%), Gaps = 31/292 (10%) Query: 2 TASSVLLHTGQKMPLIGLGTWKSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALK 61 T S++L+ G +P +G G +K P + A++ AL GYRHID A++YGNE +G A+ Sbjct: 1 TVPSIVLNDGNSIPQLGYGVFKVPPADTQRAVEEALEVGYRHIDTAAIYGNEEGVGAAIA 60 Query: 62 ESVGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERG 121 S + R++LF+T+KLWN +H ++ A+ ++LA L L+ +DLYL+HWP Sbjct: 61 ASGIA-----RDDLFITTKLWNDRHDGDEPAAAIAESLAKLALDQVDLYLVHWP------ 109 Query: 122 DNPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVRPA 181 P N Y W+ + L A GL +++G+SN ++ +++ V PA Sbjct: 110 -TPAADN-----------YVHAWEKMIELRAAGLTRSIGVSNHLVPHLERIVAATGVVPA 157 Query: 182 VLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEKH 241 V Q+E HP Q E+ A +++ ++ PLG + EPV A A H Sbjct: 158 VNQIELHPAYQQREITDWAAAHDVKIESWGPLGQGKY-------DLFGAEPVT-AAAAAH 209 Query: 242 GRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALN 293 G++PAQ +LRW +Q+ + PKS+ R+ +N+ VFDF + E+ +DA++ Sbjct: 210 GKTPAQAVLRWHLQKGFVVFPKSVRRERLEENLDVFDFDLTDTEIAAIDAMD 261 >4IJC-A nrPDB Length = 344 Score = 167 bits (424), Expect = 4e-42, Method: Compositional matrix adjust. Identities = 109/308 (35%), Positives = 174/308 (56%), Gaps = 29/308 (9%) Query: 8 LHTGQKMPLIGLGTWK--SEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALKESVG 65 L+ G ++P +GLGT + + K A+K A+ AGYRHID A Y E +GEA+KE + Sbjct: 27 LNNGVRIPALGLGTANPHEKLAETKQAVKAAIKAGYRHIDTAWAYETEPFVGEAIKELLE 86 Query: 66 SGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNP- 124 G ++ RE+LF+T+K+W ++V+ +L ++L L LEY+DL L HWP FE+ +P Sbjct: 87 DG-SIKREDLFITTKVWPVLW--DEVDRSLNESLKALGLEYVDLLLQHWPLCFEKIKDPK 143 Query: 125 -------FPKNADGTVRYDST-HYKETWKALEVLVAK---GLVKALGLSNFNSRQIDDVL 173 P + G Y + Y ET+K LE + V+A+G+SNF+ ++ ++ Sbjct: 144 GISGLVKTPVDDSGKTMYAADGDYLETYKQLEKIYLDPNDHRVRAIGVSNFSIEYLERLI 203 Query: 174 SVASVRPAVLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPV 233 V+P V QVE HP+L Q EL C + +TAYSPLGS P+ L+ P+ Sbjct: 204 KECRVKPTVNQVETHPHLPQMELRKFCFMHDILLTAYSPLGSHGA----PN----LKIPL 255 Query: 234 VLALAEKHGRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALN 293 V LAEK+ + +L+ + +++ I IP+S+NP RI +I+ T +E+++L+ Sbjct: 256 VKKLAEKYNVTGNDLLISYHIRQGTIVIPRSLNPVRISSSIEFASLT--KDELQELNDFG 313 Query: 294 KNW--RYI 299 + + R+I Sbjct: 314 EKYPVRFI 321 >4OTK-A nrPDB Length = 318 Score = 162 bits (411), Expect = 2e-40, Method: Compositional matrix adjust. Identities = 99/295 (33%), Positives = 144/295 (48%), Gaps = 33/295 (11%) Query: 3 ASSVLLHTGQKMPLIGLGTWKSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALKE 62 A S+ L+ MP++GLG + + + A+ AL G R ID A YGNE +G A+ Sbjct: 46 APSITLNDEHTMPVLGLGVAELSDDETERAVSAALEIGCRLIDTAYAYGNEAAVGRAIAA 105 Query: 63 SVGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGD 122 S V REELFVT+KL + A R +L L L+Y+DLYL+HWP Sbjct: 106 S-----GVAREELFVTTKLATPDQGFTRSQEACRASLDRLGLDYVDLYLIHWPAP----- 155 Query: 123 NPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVRPAV 182 P K Y + W + +G +++G+SNF + I++++ + V PAV Sbjct: 156 -PVGK------------YVDAWGGMIQSRGEGHARSIGVSNFTAENIENLIDLTFVTPAV 202 Query: 183 LQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEKHG 242 Q+E HP L Q+EL + +Y PL LL+ P V ++A ++ Sbjct: 203 NQIELHPLLNQDELRKANAQHTVVTQSYCPLALGR----------LLDNPTVTSIASEYV 252 Query: 243 RSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWR 297 ++PAQ+LLRW +Q + +S P RI N VFDF + E M L LN R Sbjct: 253 KTPAQVLLRWNLQLGNAVVVRSARPERIASNFDVFDFELAAEHMDALGGLNDGTR 307 >3UP8-A nrPDB Length = 298 Score = 158 bits (399), Expect = 4e-39, Method: Compositional matrix adjust. Identities = 89/293 (30%), Positives = 158/293 (53%), Gaps = 36/293 (12%) Query: 11 GQKMPLIGLGTWKSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALKESVGSGKAV 70 G +P +G GT++ +V + AL G+RH+D A +YGNE E+GEA+++S + Sbjct: 31 GANIPALGFGTFRMSGAEVLRILPQALKLGFRHVDTAQIYGNEAEVGEAIQKS-----GI 85 Query: 71 PREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNAD 130 PR ++F+T+K+W + + ++ ++L L+ +++DL L+HWP + D P Sbjct: 86 PRADVFLTTKVWVDNYRHDAFIASVDESLRKLRTDHVDLLLLHWPGS----DVPMA---- 137 Query: 131 GTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVRPAVLQVECHPY 190 E AL + G V+ +G+SNFN+ Q+++ ++ A QVE HPY Sbjct: 138 -----------ERIGALNEVRNAGKVRHIGISNFNTTQMEEAARLSDAPIATNQVEYHPY 186 Query: 191 LAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEKHGRSPAQILL 250 L Q +++ G+ +T+Y + + + P +P+L E + +HG++ AQ+ L Sbjct: 187 LDQTKVLQTARRLGMSLTSYYAMANG----KVPADPLLTE------IGGRHGKTAAQVAL 236 Query: 251 RWQVQRK-VICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNK-NWRYIVP 301 RW VQ++ VI + K+ +R+ +N +FDF + EEM + L + N R + P Sbjct: 237 RWLVQQQDVIVLSKTATEARLKENFAIFDFALTREEMAAVRELARPNGRIVNP 289 >3WG6-A nrPDB Length = 307 Score = 138 bits (347), Expect = 3e-33, Method: Compositional matrix adjust. Identities = 96/313 (30%), Positives = 152/313 (48%), Gaps = 45/313 (14%) Query: 1 MTASSVLLHTGQKMPLIGLGTWKSE--------PGQVKAAIKHALSAGYRHIDCASVYGN 52 + L G K+P + GT Q+ ++ AL +G+RHID A +YG Sbjct: 6 LAGKEFKLSNGNKIPAVAFGTGTKYFKRGHNDLDKQLIGTLELALRSGFRHIDGAEIYGT 65 Query: 53 ETEIGEALKESVGSGKAVPREELFVTSKLWNTKHHPEDVE--------PALRKTLADLQL 104 EIG ALK +VG + R+++F+T K +N+ +H D + AL+ L DL L Sbjct: 66 NKEIGIALK-NVG----LNRKDVFITDK-YNSGNHTYDGKHSKHQNPYNALKADLEDLGL 119 Query: 105 EYLDLYLMHWPYAFERGDNPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNF 164 EY+DLYL+H+PY E+ +D E W+ LE +GL + +G+SNF Sbjct: 120 EYVDLYLIHFPYISEKSHG-----------FDLV---EAWRYLERAKNEGLARNIGVSNF 165 Query: 165 NSRQIDDVLSVASVR-PAVLQVECHPYLAQNE--LIAHCHARGLEVTAYSPLGSSDRAWR 221 + +L + P V Q+E YL ++ + +G+ + AY PLG + Sbjct: 166 TIENLKSILDANTDSIPVVNQIEFSAYLQDQTPGIVEYSQQQGILIEAYGPLGPITQGRP 225 Query: 222 HPDEPVLLEEPVVLALAEKHGRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTF 281 P + VL + L+EK+ R+ QILLRW +QR ++ I + RI +++FDF Sbjct: 226 GPLDKVLSK------LSEKYKRNEGQILLRWVLQRGILPITTTSKEERINDVLEIFDFEL 279 Query: 282 SPEEMKQLDALNK 294 E+ Q+ + K Sbjct: 280 DKEDEDQITKVGK 292 >4H8N-A nrPDB Length = 310 Score = 120 bits (300), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 82/270 (30%), Positives = 141/270 (52%), Gaps = 41/270 (15%) Query: 36 ALSAGYRHIDCASVYGNETEIGEALKESVGSGKAVPREELFVTSKL---WNT-KHHPEDV 91 L G+RHID A Y + E+GEALK + VPRE+++VT+K W + K + + Sbjct: 52 GLKLGFRHIDTAEAYNTQKEVGEALKRT-----DVPREDIWVTTKYSPGWGSIKAYSKSP 106 Query: 92 EPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNADGTVRYDSTH---YKETWKALE 148 ++ K LA L ++Y+DL+L+H P+ + TH ++ W+AL Sbjct: 107 SDSIDKALAQLGVDYVDLFLIHSPF----------------FTTEQTHGYTLEQAWEALV 150 Query: 149 VLVAKGLVKALGLSNFNSRQIDDVLSVA---SVRPAVLQVECHPYLAQNE---LIAHCHA 202 G V+ +G+SN ++ + + + P V Q+E HP+L QN+ ++ C Sbjct: 151 EAKKAGKVREIGISNAAIPHLEKLFAASPSPEYYPVVNQIEFHPFL-QNQSKNIVRFCQE 209 Query: 203 RGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEKHGRSPAQILLRWQVQRKVICIP 262 G+ V A+SPL R E L E + LAEK+ ++ AQ+LLR+ +QR ++ + Sbjct: 210 HGILVEAFSPLAPLARV-----ETNALAE-TLKRLAEKYKKTEAQVLLRYTLQRGILPVT 263 Query: 263 KSINPSRILQNIQVFDFTFSPEEMKQLDAL 292 S SR+ +++ +FDF + EE+ +++ + Sbjct: 264 TSSKESRLKESLNLFDFELTDEEVNEINKI 293 >1PYF-A nrPDB Length = 312 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 75/323 (23%), Positives = 131/323 (40%), Gaps = 77/323 (23%) Query: 17 IGLGT-----------WKSEPGQVKAAIKHALSAGYRHIDCASVYG---NETEIGEALKE 62 IGLGT E G K ++ A+ G +D A +YG +E IGE L+E Sbjct: 16 IGLGTNAVGGHNLYPNLNEETG--KELVREAIRNGVTMLDTAYIYGIGRSEELIGEVLRE 73 Query: 63 SVGSGKAVPREELFVTSKLWNTK--------HHPEDVEPALRKTLADLQLEYLDLYLMHW 114 RE++ + +K + K + P+ ++ ++ ++L L +Y+DL+ +H+ Sbjct: 74 -------FNREDVVIATKAAHRKQGNDFVFDNSPDFLKKSVDESLKRLNTDYIDLFYIHF 126 Query: 115 PYAFERGDNPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLS 174 P D PK+ E AL + G ++++G+SNF+ Q+ + Sbjct: 127 P------DEHTPKD-------------EAVNALNEMKKAGKIRSIGVSNFSLEQLKEANK 167 Query: 175 VASVRPAVLQVECH--PYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEP 232 V VLQ E + A+ + + Y PL S A ++ ++ E Sbjct: 168 DGLV--DVLQGEYNLLNREAEKTFFPYTKEHNISFIPYFPLVSGLLAGKYTEDTTFPEGD 225 Query: 233 V---------------------VLALAEKHGRSPAQILLRWQVQRKV--ICIPKSINPSR 269 + + +AEKH I+L W + R I IP + + Sbjct: 226 LRNEQEHFKGERFKENIRKVNKLAPIAEKHNVDIPHIVLAWYLARPEIDILIPGAKRADQ 285 Query: 270 ILQNIQVFDFTFSPEEMKQLDAL 292 ++ NI+ D T S E++ +D L Sbjct: 286 LIDNIKTADVTLSQEDISFIDKL 308 >1LQA-A nrPDB Length = 346 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 82/355 (23%), Positives = 144/355 (40%), Gaps = 78/355 (21%) Query: 9 HTGQKMPLIGLGTW----KSEPGQVKAAIKHALSAGYRHIDCASVYG----------NET 54 H+ ++ +GLGT ++ A + +A++ G ID A +Y ET Sbjct: 8 HSSLEVSTLGLGTMTFGEQNSEADAHAQLDYAVAQGINLIDVAEMYPVPPRPETQGLTET 67 Query: 55 EIGEALKESVGSGKAVPREELFVTSKLWN-TKHHPEDVEP-----------ALRKTLADL 102 +G L K RE+L + SK+ ++++ + + P AL +L L Sbjct: 68 YVGNWL------AKHGSREKLIIASKVSGPSRNNDKGIRPDQALDRKNIREALHDSLKRL 121 Query: 103 QLEYLDLYLMHWPYAFERGDNPFPKNADGTVRYDSTHYKETWKALEVLVA------KGLV 156 Q +YLDLY +HWP +R P N G + Y T L+ L A G + Sbjct: 122 QTDYLDLYQVHWP---QR-----PTNCFGKLGYSWTDSAPAVSLLDTLDALAEYQRAGKI 173 Query: 157 KALGLSNFNSRQIDDVLSVASVR--PAVLQVECHPYLAQNE-----LIAHCHARGLEVTA 209 + +G+SN + + L +A P ++ ++ +PY N L G+E+ A Sbjct: 174 RYIGVSNETAFGVMRYLHLADKHDLPRIVTIQ-NPYSLLNRSFEVGLAEVSQYEGVELLA 232 Query: 210 YSPLGSS--------------------DRAWRHPDEPVLLEEPVVLALAEKHGRSPAQIL 249 YS LG R R+ E + +A +HG PAQ+ Sbjct: 233 YSCLGFGTLTGKYLNGAKPAGARNTLFSRFTRYSGEQTQKAVAAYVDIARRHGLDPAQMA 292 Query: 250 LRWQVQRKVICIPKSINPSRILQ---NIQVFDFTFSPEEMKQLDALNKNWRYIVP 301 L + V+R+ + + + Q NI+ S + + +++A+++ + Y P Sbjct: 293 LAF-VRRQPFVASTLLGATTMDQLKTNIESLHLELSEDVLAEIEAVHQVYTYPAP 346 >1PZ1-A nrPDB Length = 333 Score = 57.4 bits (137), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 61/236 (25%), Positives = 103/236 (43%), Gaps = 64/236 (27%) Query: 5 SVLLHTGQKMPLIGLGTWK--------SEPGQVKAAIKHALSAGYRHIDCASVYG---NE 53 + + TG + IGLGTW ++ I+ AL G ID A YG +E Sbjct: 4 TSIADTGIEASRIGLGTWAIGGTMWGGTDEKTSIETIRAALDQGITLIDTAPAYGFGQSE 63 Query: 54 TEIGEALKESVGSGKAVPREELFVTSKL---W---------NTKHHPEDVEPALRKTLAD 101 +G+A+KE + R+++ + +K W N E+VE +L++ Sbjct: 64 EIVGKAIKEYM------KRDQVILATKTALDWKNNQLFRHANRARIVEEVENSLKR---- 113 Query: 102 LQLEYLDLYLMHWPYAFERGDNPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGL 161 LQ +Y+DLY +HWP D P +ET + ++ L G ++A+G+ Sbjct: 114 LQTDYIDLYQVHWP------DPLVP-------------IEETAEVMKELYDAGKIRAIGV 154 Query: 162 SNFNSRQIDDVLSVA---SVRPAV------LQVECHPYLAQNELIAHCHA---RGL 205 SNF+ Q+D +VA +++P ++ PY N++ + RGL Sbjct: 155 SNFSIEQMDTFRAVAPLHTIQPPYNLFEREMEESVLPYAKDNKITTLLYGSLCRGL 210 >3N6Q-A nrPDB Length = 346 Score = 49.3 bits (116), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 72/333 (21%), Positives = 138/333 (41%), Gaps = 76/333 (22%) Query: 10 TGQKMPLIGLGTWKSEPGQV------KAAIKHALSAGYRHIDCASVYG-----NETEIGE 58 +G ++P + LG W + G V +A ++ A G H D A+ YG E G Sbjct: 21 SGLRLPALSLGLWHN-FGHVNALESQRAILRKAFDLGITHFDLANNYGPPPGSAEENFGR 79 Query: 59 ALKESVGSGKAVPREELFVTSK----LW----NTKHHPEDVEPALRKTLADLQLEYLDLY 110 L+E A R+EL +++K +W + + + +L ++L + LEY+D++ Sbjct: 80 LLREDF----AAYRDELIISTKAGYDMWPGPYGSGGSRKYLLASLDQSLKRMGLEYVDIF 135 Query: 111 LMHWPYAFERGDNPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQID 170 H R D ++T +ET AL V G +G+S+++ + Sbjct: 136 YSH------RVD-------------ENTPMEETASALAHAVQSGKALYVGISSYSPERTQ 176 Query: 171 DVLSVASVRPAVLQVECHPY------LAQNELIAHCHARGLEVTAYSPLGSS-------- 216 ++ + L + Y + ++ L+ G+ A++PL Sbjct: 177 KMVELLREWKIPLLIHQPSYNLLNRWVDKSGLLDTLQNNGVGCIAFTPLAQGLLTGKYLN 236 Query: 217 -----DRAWRHPDE-----PVLLEEPVVLAL------AEKHGRSPAQILLRWQVQ--RKV 258 R R ++ P +L E + +L A++ G+S AQ+ L W ++ R Sbjct: 237 GIPQDSRMHREGNKVRGLTPKMLTEANLNSLRLLNEMAQQRGQSMAQMALSWLLKDDRVT 296 Query: 259 ICIPKSINPSRILQNIQVF-DFTFSPEEMKQLD 290 + + ++ +N+Q + TFS +E+ Q+D Sbjct: 297 SVLIGASRAEQLEENVQALNNLTFSTKELAQID 329 >3EB3-A nrPDB Length = 327 Score = 47.4 bits (111), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 70/317 (22%), Positives = 134/317 (42%), Gaps = 73/317 (23%) Query: 7 LLHTGQKMPLIGLGTWKSEPGQVKAAI-KHALSAGYRH----IDCASVYGN---ETEIGE 58 L +G ++ +GLGTW + GQ+ + +H ++ Y + D A VY E +G Sbjct: 8 LGKSGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVLGN 67 Query: 59 ALKESVGSGKAVPREELFVTSKLW-NTKHHPED------VEPALRKTLADLQLEYLDLYL 111 +K+ K R L +T+K++ K E + L+ +L LQLEY+D+ Sbjct: 68 IIKK-----KGWRRSSLVITTKIFAGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVF 122 Query: 112 MHWPYAFERGDNPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDD 171 + P P +T +ET +A+ ++ +G+ G S ++S +I + Sbjct: 123 ---------ANRPDP----------NTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIME 163 Query: 172 VLSVAS----VRPAVLQVECHPYLAQN---ELIAHCHARGLEVTAYSPLG---------- 214 SVA + P Q E H + + +L H G+ +SPL Sbjct: 164 AYSVARQFNLIPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDS 223 Query: 215 -------SSDRAWRHPDEPVLLEE--------PVVLALAEKHGRSPAQILLRWQVQRKVI 259 +S + ++ + +L EE + A+AE+ G + Q+ + W ++ + + Sbjct: 224 GIPPYSRASLKGYQWLKDKILSEEGRRQQAKLKELQAIAERLGCTLPQLAIAWCLRNEGV 283 Query: 260 --CIPKSINPSRILQNI 274 + + N ++++NI Sbjct: 284 SSVLLGASNAEQLMENI 300 >1GVE-A nrPDB Length = 327 Score = 41.2 bits (95), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 51/198 (25%), Positives = 81/198 (40%), Gaps = 36/198 (18%) Query: 31 AAIKHALSAGYRHIDCASVYGN---ETEIGEALKESVGSGKAVPREELFVTSK---LWNT 84 A+++ L G+ ID A VY N ET +G+ SG V + +K ++ Sbjct: 26 ASVRAFLQRGHTEIDTAFVYANGQSETILGDLGLGLGRSGCKVK-----IATKAAPMFGK 80 Query: 85 KHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNADGTVRYDSTHYKETW 144 P DV L +L LQ +DL+ +H+P D+ P +ET Sbjct: 81 TLKPADVRFQLETSLKRLQCPRVDLFYLHFP------DHGTP-------------IEETL 121 Query: 145 KALEVLVAKGLVKALGLSNFNSRQIDDVLSVAS----VRPAVLQVECHPYLAQ--NELIA 198 +A L +G LGLSN+ S ++ ++ ++ + P V Q + Q EL Sbjct: 122 QACHQLHQEGKFVELGLSNYVSWEVAEICTLCKKNGWIMPTVYQGMYNAITRQVETELFP 181 Query: 199 HCHARGLEVTAYSPLGSS 216 GL A++PL Sbjct: 182 CLRHFGLRFYAFNPLAGG 199 >1OG6-A nrPDB Length = 298 Score = 38.1 bits (87), Expect = 0.005, Method: Compositional matrix adjust. Identities = 47/185 (25%), Positives = 66/185 (35%), Gaps = 37/185 (20%) Query: 19 LGTWKSEPGQVKAAIKHALSAGYRHIDCASVYGN---ETEIGEALK-----------ESV 64 L W Q+ + I+ L G +D A +YG E GEALK S Sbjct: 24 LMDWNMSARQLVSFIEEHLDLGVTTVDHADIYGGYQCEAAFGEALKLAPHLRERMEIVSK 83 Query: 65 GSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNP 124 REE + + + H + E ++L +L ++LDL L+H P D Sbjct: 84 CGIATTAREENVIGHYITDRDHIIKSAE----QSLINLATDHLDLLLIHRPDPLMDAD-- 137 Query: 125 FPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVRPAVLQ 184 E A + L G V+ G+SNF Q + S A Q Sbjct: 138 -----------------EVADAFKHLHQSGKVRHFGVSNFTPAQFALLQSRLPFTLATNQ 180 Query: 185 VECHP 189 VE P Sbjct: 181 VEISP 185 >4R9O-A nrPDB Length = 301 Score = 36.2 bits (82), Expect = 0.022, Method: Compositional matrix adjust. Identities = 45/184 (24%), Positives = 72/184 (39%), Gaps = 35/184 (19%) Query: 19 LGTWKSEPGQVKAAIKHALSAGYRHIDCASVYGN---ETEIGEAL------KESVGSGKA 69 L W Q+ + I+ L G +D A +YG E GEAL +E + + Sbjct: 27 LMDWNMSARQLVSFIEEHLDLGVTTVDHADIYGGYQCEAAFGEALTLAPHLREKL---QI 83 Query: 70 VPREELFVTSKLWNT-KHHPED---VEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPF 125 V + + T++ N H+ D + + ++L +L +YLD+ L+H P D+ Sbjct: 84 VTKCGIATTARAENKLGHYITDRRHIILSAEQSLKNLATDYLDMLLIHRPDPLMDADD-- 141 Query: 126 PKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVRPAVLQV 185 +A + L G V+ G+SNF Q + S A QV Sbjct: 142 -----------------VAEAFQHLHQSGKVRHFGVSNFTPAQFTLLQSRLPFTLATNQV 184 Query: 186 ECHP 189 E P Sbjct: 185 EISP 188 >2BP1-A nrPDB Length = 360 Score = 35.0 bits (79), Expect = 0.048, Method: Compositional matrix adjust. Identities = 45/185 (24%), Positives = 73/185 (39%), Gaps = 26/185 (14%) Query: 37 LSAGYRHIDCASVYGNETEIGEALKESVGSGKAVPREELFVTSKLWNTKH-HPEDVEPAL 95 L G+ +D A +Y + +G G R ++ + W+ K P+ V L Sbjct: 65 LERGHTELDTAFMYSDGQSETILGGLGLGLGGGDCRVKIATKANPWDGKSLKPDSVRSQL 124 Query: 96 RKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNADGTVRYDSTHYKETWKALEVLVAKGL 155 +L LQ +DL+ +H P D+ P +ET A + L +G Sbjct: 125 ETSLKRLQCPQVDLFYLHAP------DHGTP-------------VEETLHACQRLHQEGK 165 Query: 156 VKALGLSNFNSRQIDDVLSVAS----VRPAVLQVECHPYLAQ--NELIAHCHARGLEVTA 209 LGLSN+ S ++ ++ ++ + P V Q + Q EL GL A Sbjct: 166 FVELGLSNYASWEVAEICTLCKSNGWILPTVYQGMYNATTRQVETELFPCLRHFGLRFYA 225 Query: 210 YSPLG 214 Y+PL Sbjct: 226 YNPLA 230 >5XKX-A nrPDB Length = 407 Score = 33.9 bits (76), Expect = 0.11, Method: Compositional matrix adjust. Identities = 37/143 (25%), Positives = 62/143 (43%), Gaps = 25/143 (17%) Query: 4 SSVLLHTGQKMPLIGLGTWKSEPGQVK------AAIKHALSAGYRHIDCASVYGNETEIG 57 + LH + + + GL T S G + A GY + + +GN I Sbjct: 180 TDTTLHWTKDVSIKGLPTLWSSVGWIPFYAENPNAGSDRFRGGYLYAEVMGPWGN-LRIK 238 Query: 58 EALKESVGSGKAVPREELFVTSKLWNTK-----HHPEDVEPALRKTLADLQLEYLDLYLM 112 E E VG+ E+ +T++L+NT HHP+++ L K Q +++ +M Sbjct: 239 EIDGEKVGA-------EIGMTAQLFNTSYPYHYHHPQEIYMTLTKPQCIDQNKHM---VM 288 Query: 113 HWP---YAFERGDNPFPKNADGT 132 HW + +R DN + N DG+ Sbjct: 289 HWDNNQFKQKRSDNGWTVNIDGS 311 >2C91-A nrPDB Length = 338 Score = 33.5 bits (75), Expect = 0.13, Method: Compositional matrix adjust. Identities = 35/135 (25%), Positives = 55/135 (40%), Gaps = 25/135 (18%) Query: 88 PEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNADGTVRYDSTHYKETWKAL 147 P+ + L +L LQ +DL+ +H P D+ ST +ET A Sbjct: 95 PDSIRSQLETSLKRLQCPRVDLFYLHAP------DH-------------STPVEETLCAC 135 Query: 148 EVLVAKGLVKALGLSNFNSRQIDDVLSVAS----VRPAVLQVECHPYLAQ--NELIAHCH 201 L +G LGLSN+ S ++ ++ ++ + P V Q + Q EL+ Sbjct: 136 HQLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQGMYNATTRQVEAELLPCLR 195 Query: 202 ARGLEVTAYSPLGSS 216 GL AY+PL Sbjct: 196 HFGLRFYAYNPLAGG 210 >2CLP-A nrPDB Length = 347 Score = 32.0 bits (71), Expect = 0.36, Method: Compositional matrix adjust. Identities = 34/142 (23%), Positives = 57/142 (40%), Gaps = 25/142 (17%) Query: 81 LWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNADGTVRYDSTHY 140 L+ P+ + L +L LQ +DL+ +H P D+ ST Sbjct: 97 LFGNSLKPDSLRFQLETSLKRLQCPRVDLFYLHMP------DH-------------STPV 137 Query: 141 KETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVAS----VRPAVLQVECHPYLAQ--N 194 +ET +A L +G LGLSN+ + ++ ++ ++ + P V Q + Q Sbjct: 138 EETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYNAITRQVET 197 Query: 195 ELIAHCHARGLEVTAYSPLGSS 216 EL GL A++PL Sbjct: 198 ELFPCLRHFGLRFYAFNPLAGG 219 >3PS9-A nrPDB Length = 676 Score = 29.3 bits (64), Expect = 2.4, Method: Compositional matrix adjust. Identities = 32/134 (23%), Positives = 51/134 (38%), Gaps = 11/134 (8%) Query: 170 DDVLSVASVRPAVLQ--VECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPV 227 DD + S++PA L+ E P + + + GLE T Y LG + R P+ P Sbjct: 6 DDKMKHYSIQPANLEFNAEGTPVSRDFDDVYFSNDNGLEETRYVFLGGNQLEVRFPEHPH 65 Query: 228 LLEEPVVLALAEKHGRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMK 287 L +AE + L WQ + + +P LQ + F P Sbjct: 66 PL-----FVVAESGFGTGLNFLTLWQAFDQF----REAHPQAQLQRLHFISFEKFPLTRA 116 Query: 288 QLDALNKNWRYIVP 301 L +++W + P Sbjct: 117 DLALAHQHWPELAP 130 >4F5M-A nrPDB Length = 406 Score = 28.9 bits (63), Expect = 3.0, Method: Compositional matrix adjust. Identities = 25/81 (30%), Positives = 38/81 (46%), Gaps = 13/81 (16%) Query: 86 HHPEDVEPALR--KTLADLQLEYLDLYLMHWPY-AFERGDNPFPKNADGTVRYDSTHYKE 142 H+P ++P L +TLA L +E L L + Y F RG ++A+G + + H Sbjct: 192 HNPTGIDPTLEQWQTLAQLSVEKGWLPLFDFAYQGFARG---LEEDAEGLRAFAAMHK-- 246 Query: 143 TWKALEVLVAKGLVKALGLSN 163 E++VA K GL N Sbjct: 247 -----ELIVASSYSKNFGLYN 262 >3EC2-A nrPDB Length = 180 Score = 28.5 bits (62), Expect = 3.6, Method: Compositional matrix adjust. Identities = 13/28 (46%), Positives = 19/28 (67%) Query: 262 PKSINPSRILQNIQVFDFTFSPEEMKQL 289 PK+++ +R L I+VF F+PEE K L Sbjct: 14 PKNVSQNRALLTIRVFVHNFNPEEGKGL 41 >2QY6-A nrPDB Length = 257 Score = 27.7 bits (60), Expect = 7.5, Method: Compositional matrix adjust. Identities = 30/127 (23%), Positives = 48/127 (37%), Gaps = 11/127 (8%) Query: 177 SVRPAVLQV--ECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVV 234 S++PA L+ E P + + + GLE T Y LG + R P+ P L Sbjct: 7 SIQPANLEFNAEGTPVSRDFDDVYFSNDNGLEETRYVFLGGNQLEARFPEHPHPL----- 61 Query: 235 LALAEKHGRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNK 294 +AE + L WQ + + +P LQ + F P L ++ Sbjct: 62 FVVAESGFGTGLNFLTLWQAFDQF----REAHPQAQLQRLHFISFEKFPLTRADLALAHQ 117 Query: 295 NWRYIVP 301 +W + P Sbjct: 118 HWPELAP 124 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 4GAC-A nrPDB 514 e-146 2ALR-A nrPDB 514 e-146 1HQT-A nrPDB 512 e-146 1ZUA-X nrPDB 462 e-130 4JQA-A nrPDB 457 e-129 1Q5M-A nrPDB 451 e-127 2FVL-A nrPDB 450 e-127 5JM5-A nrPDB 449 e-127 1DLA-A nrPDB 439 e-124 3RX4-A nrPDB 439 e-123 3G1R-A nrPDB 437 e-123 2HE8-A nrPDB 437 e-123 1AFS-A nrPDB 431 e-121 5UXF-A nrPDB 431 e-121 1C9W-A nrPDB 427 e-120 1FRB-A nrPDB 423 e-119 4HBK-A nrPDB 422 e-118 3O3R-A nrPDB 418 e-117 5ZCM-A nrPDB 397 e-111 5JH1-A nrPDB 397 e-111 3H7U-A nrPDB 397 e-111 5Z6T-A nrPDB 395 e-110 1K8C-A nrPDB 390 e-109 3WCZ-A nrPDB 382 e-106 3H7R-A nrPDB 370 e-103 4GIE-A nrPDB 368 e-102 3KRB-A nrPDB 367 e-102 1VBJ-A nrPDB 366 e-102 4F40-A nrPDB 365 e-101 2BGQ-A nrPDB 361 e-100 1VP5-A nrPDB 353 6e-98 1QWK-A nrPDB 352 1e-97 1MZR-A nrPDB 345 2e-95 4MHB-A nrPDB 334 3e-92 3D3F-A nrPDB 333 5e-92 4OTK-A nrPDB 319 1e-87 4IJC-A nrPDB 313 1e-85 1A80-A nrPDB 311 3e-85 3UP8-A nrPDB 301 2e-82 3WG6-A nrPDB 269 1e-72 4H8N-A nrPDB 257 3e-69 1LQA-A nrPDB 207 5e-54 1PYF-A nrPDB 202 1e-52 3EB3-A nrPDB 201 3e-52 3N6Q-A nrPDB 192 1e-49 1PZ1-A nrPDB 178 3e-45 1GVE-A nrPDB 146 1e-35 Sequences not found previously or not previously below threshold: 2CLP-A nrPDB 140 1e-33 2C91-A nrPDB 132 2e-31 2BP1-A nrPDB 131 5e-31 4R9O-A nrPDB 118 3e-27 1OG6-A nrPDB 110 1e-24 4EXA-A nrPDB 75 5e-14 4EHI-A nrPDB 30 1.2 4WO8-A nrPDB 30 1.3 1JPH-A nrPDB 30 1.6 4FO0-A nrPDB 30 1.7 2WUA-A nrPDB 30 1.9 5ZF1-A nrPDB 29 2.3 4YWJ-A nrPDB 29 2.3 2BS2-A nrPDB 29 2.5 3ZL8-A nrPDB 29 2.7 1K1Y-A nrPDB 29 2.7 5GJU-A nrPDB 29 2.8 1XKE-A nrPDB 29 2.8 2W8D-A nrPDB 29 3.0 3OF5-A nrPDB 29 3.2 4GL2-A nrPDB 29 3.3 4BKP-A nrPDB 29 3.5 5H82-A nrPDB 29 3.6 3MMA-A nrPDB 29 3.8 3Q3N-A nrPDB 29 3.8 3PNZ-A nrPDB 28 4.6 4TSK-A nrPDB 28 4.9 4P22-A nrPDB 28 5.2 3IVU-A nrPDB 28 6.4 4ZE8-A nrPDB 28 8.4 >4GAC-A nrPDB Length = 324 Score = 514 bits (1324), Expect = e-146, Method: Composition-based stats. Identities = 324/324 (100%), Positives = 324/324 (100%) Query: 2 TASSVLLHTGQKMPLIGLGTWKSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALK 61 TASSVLLHTGQKMPLIGLGTWKSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALK Sbjct: 1 TASSVLLHTGQKMPLIGLGTWKSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALK 60 Query: 62 ESVGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERG 121 ESVGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERG Sbjct: 61 ESVGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERG 120 Query: 122 DNPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVRPA 181 DNPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVRPA Sbjct: 121 DNPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVRPA 180 Query: 182 VLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEKH 241 VLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEKH Sbjct: 181 VLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEKH 240 Query: 242 GRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWRYIVP 301 GRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWRYIVP Sbjct: 241 GRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWRYIVP 300 Query: 302 MITVDGKRVPRDAGHPLYPFNDPY 325 MITVDGKRVPRDAGHPLYPFNDPY Sbjct: 301 MITVDGKRVPRDAGHPLYPFNDPY 324 >2ALR-A nrPDB Length = 324 Score = 514 bits (1323), Expect = e-146, Method: Composition-based stats. Identities = 302/324 (93%), Positives = 313/324 (96%) Query: 2 TASSVLLHTGQKMPLIGLGTWKSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALK 61 AS VLLHTGQKMPLIGLGTWKSEPGQVKAA+K+ALS GYRHIDCA++YGNE EIGEALK Sbjct: 1 AASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALK 60 Query: 62 ESVGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERG 121 E VG GKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERG Sbjct: 61 EDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERG 120 Query: 122 DNPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVRPA 181 DNPFPKNADGT+ YDSTHYKETWKALE LVAKGLV+ALGLSNFNSRQIDD+LSVASVRPA Sbjct: 121 DNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPA 180 Query: 182 VLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEKH 241 VLQVECHPYLAQNELIAHC ARGLEVTAYSPLGSSDRAWR PDEPVLLEEPVVLALAEK+ Sbjct: 181 VLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKY 240 Query: 242 GRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWRYIVP 301 GRSPAQILLRWQVQRKVICIPKSI PSRILQNI+VFDFTFSPEEMKQL+ALNKNWRYIVP Sbjct: 241 GRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIVP 300 Query: 302 MITVDGKRVPRDAGHPLYPFNDPY 325 M+TVDGKRVPRDAGHPLYPFNDPY Sbjct: 301 MLTVDGKRVPRDAGHPLYPFNDPY 324 >1HQT-A nrPDB Length = 326 Score = 512 bits (1318), Expect = e-146, Method: Composition-based stats. Identities = 295/325 (90%), Positives = 312/325 (96%) Query: 1 MTASSVLLHTGQKMPLIGLGTWKSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEAL 60 M AS VLLHTGQKMPLIGLGTWKSEPGQVKAAIK+AL+ GYRHIDCA+++GNE EIGEAL Sbjct: 2 MAASCVLLHTGQKMPLIGLGTWKSEPGQVKAAIKYALTVGYRHIDCAAIFGNELEIGEAL 61 Query: 61 KESVGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFER 120 +E+VG GKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFER Sbjct: 62 QETVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFER 121 Query: 121 GDNPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVRP 180 GDNPFPKNADGT+RYD+THYK+TWKALE LVAKGLV+ALGLSNF+SRQIDDVLSVASVRP Sbjct: 122 GDNPFPKNADGTIRYDATHYKDTWKALEALVAKGLVRALGLSNFSSRQIDDVLSVASVRP 181 Query: 181 AVLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEK 240 AVLQVECHPYLAQNELIAHC ARGLEVTAYSPLGSSDRAWR P+EPVLLEEPVV ALAEK Sbjct: 182 AVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPNEPVLLEEPVVQALAEK 241 Query: 241 HGRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWRYIV 300 + RSPAQILLRWQVQRKVICIPKS+ PSRI QNIQVFDFTFSPEEMKQLDALNKN R+IV Sbjct: 242 YNRSPAQILLRWQVQRKVICIPKSVTPSRIPQNIQVFDFTFSPEEMKQLDALNKNLRFIV 301 Query: 301 PMITVDGKRVPRDAGHPLYPFNDPY 325 PM+TVDGKRVPRDAGHPLYPFNDPY Sbjct: 302 PMLTVDGKRVPRDAGHPLYPFNDPY 326 >1ZUA-X nrPDB Length = 317 Score = 462 bits (1189), Expect = e-130, Method: Composition-based stats. Identities = 163/325 (50%), Positives = 218/325 (67%), Gaps = 12/325 (3%) Query: 3 ASSVLLHTGQKMPLIGLGTWKSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALKE 62 A+ V L T KMP++GLGTWKS G+VK A+K A+ AGYRHIDCA VY NE E+GEA++E Sbjct: 3 ATFVELSTKAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQE 62 Query: 63 SVGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGD 122 + KAV RE+LF+ SKLW T V A KTL DL+L YLD+YL+HWP F+ GD Sbjct: 63 KIQE-KAVKREDLFIVSKLWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKSGD 121 Query: 123 NPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVR--P 180 + FPK+ G + + W+A+E LV +GLVKALG+SNF+ QI+ +L+ ++ P Sbjct: 122 DLFPKDDKGNAIGGKATFLDAWEAMEELVDEGLVKALGVSNFSHFQIEKLLNKPGLKYKP 181 Query: 181 AVLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEK 240 QVECHPYL Q +LI +CH++G+ VTAYSPLGS DR W P++P LLE+P + +A K Sbjct: 182 VTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPKIKEIAAK 241 Query: 241 HGRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWRYIV 300 H ++ AQ+L+R+ +QR VI IPKS+ P+RI++NIQVFDF S EEM + + N+NWR Sbjct: 242 HKKTAAQVLIRFHIQRNVIVIPKSVTPARIVENIQVFDFKLSDEEMATILSFNRNWRACN 301 Query: 301 PMITVDGKRVPRDAGHPLYPFNDPY 325 V + + YPFN Y Sbjct: 302 ---------VLQSSHLEDYPFNAEY 317 >4JQA-A nrPDB Length = 331 Score = 457 bits (1177), Expect = e-129, Method: Composition-based stats. Identities = 141/327 (43%), Positives = 206/327 (62%), Gaps = 16/327 (4%) Query: 5 SVLLHTGQKMPLIGLGTWKS---EPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALK 61 V L+ G MP++G GT+ + A+K A+ AG+ HID A VY NE ++G A++ Sbjct: 7 CVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIR 66 Query: 62 ESVGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERG 121 + G +V RE++F TSKLW+ H PE V PAL ++L +LQL+Y+DLYL+H+P + + G Sbjct: 67 SKIADG-SVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPG 125 Query: 122 DNPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVR-- 179 + PK+ +G + +D+ TW+A+E GL K++G+SNFN R ++ +L+ ++ Sbjct: 126 EEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKPGLKYK 185 Query: 180 PAVLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDR-AWRHPDEPVLLEEPVVLALA 238 P QVECHPY Q +L+ C ++ + + AYS LGS W P+ PVLLE+PV+ ALA Sbjct: 186 PVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALA 245 Query: 239 EKHGRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWRY 298 +KH R+PA I LR+Q+QR V+ + KS N RI QN+QVF+F + EEMK +D LN+N RY Sbjct: 246 KKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRY 305 Query: 299 IVPMITVDGKRVPRDAGHPLYPFNDPY 325 + I AG P YPF+D Y Sbjct: 306 LTLDIF---------AGPPNYPFSDEY 323 >1Q5M-A nrPDB Length = 322 Score = 451 bits (1161), Expect = e-127, Method: Composition-based stats. Identities = 136/326 (41%), Positives = 199/326 (61%), Gaps = 16/326 (4%) Query: 6 VLLHTGQKMPLIGLGTWKS---EPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALKE 62 V L G +P++G GT+ + A K A+ AG+RHID A Y NE E+G A++ Sbjct: 7 VALSDGHFIPVLGFGTYAPEEVPKSKAMEATKIAIDAGFRHIDSAYFYKNEKEVGLAIRS 66 Query: 63 SVGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGD 122 + G V RE++F TSKLW T H PE V P+L +L +LQL+Y+DLY++H+P A + G Sbjct: 67 KIADG-TVKREDIFYTSKLWCTFHRPELVRPSLEDSLKNLQLDYVDLYIIHFPTALKPGV 125 Query: 123 NPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASV--RP 180 P + G +D+ TW+A+E GL K++G+SNFN RQ++ +L+ + +P Sbjct: 126 EIIPTDEHGKAIFDTVDICATWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKP 185 Query: 181 AVLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRA-WRHPDEPVLLEEPVVLALAE 239 QVECHPYL Q +L+ C ++G+ + AYS LGS W PVLLE+P++ ALA+ Sbjct: 186 VCNQVECHPYLNQGKLLEFCKSKGIVLVAYSALGSHREPEWVDQSAPVLLEDPLIGALAK 245 Query: 240 KHGRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWRYI 299 KH ++PA I LR+Q+QR ++ + KS RI +NIQVF+F E+MK +D+LN+N+RY+ Sbjct: 246 KHQQTPALIALRYQLQRGIVVLAKSFTEKRIKENIQVFEFQLPSEDMKVIDSLNRNFRYV 305 Query: 300 VPMITVDGKRVPRDAGHPLYPFNDPY 325 + GHP YPF+D Y Sbjct: 306 TADFAI---------GHPNYPFSDEY 322 >2FVL-A nrPDB Length = 324 Score = 450 bits (1157), Expect = e-127, Method: Composition-based stats. Identities = 142/326 (43%), Positives = 210/326 (64%), Gaps = 16/326 (4%) Query: 6 VLLHTGQKMPLIGLGTWKSEPGQVKAAI---KHALSAGYRHIDCASVYGNETEIGEALKE 62 V L+ G MP++G GT+ A+ K A+ AG+RHID A +Y NE ++G A++ Sbjct: 9 VELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVGLAIRS 68 Query: 63 SVGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGD 122 + G +V RE++F TSKLW T P+ V+PAL +L LQL+Y+DLYL+H+P A + G+ Sbjct: 69 KIADG-SVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKPGE 127 Query: 123 NPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASV--RP 180 P PK+ +G V +D+ TW+ +E GL K++G+SNFN RQ++ +L+ + +P Sbjct: 128 TPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNYRQLEMILNKPGLKYKP 187 Query: 181 AVLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSD-RAWRHPDEPVLLEEPVVLALAE 239 QVECHPYL Q++L+ C ++ + + A+S LG+ + W P+ PVLLE+PV+ ALA+ Sbjct: 188 VCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPVLCALAK 247 Query: 240 KHGRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWRYI 299 KH R+PA I LR+Q+QR V+ + KS N RI +NIQVF+F + E+MK LD LN+N+RY+ Sbjct: 248 KHKRTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNRNYRYV 307 Query: 300 VPMITVDGKRVPRDAGHPLYPFNDPY 325 V +D HP YPF+D Y Sbjct: 308 VMDFLMD---------HPDYPFSDEY 324 >5JM5-A nrPDB Length = 332 Score = 449 bits (1156), Expect = e-127, Method: Composition-based stats. Identities = 136/327 (41%), Positives = 201/327 (61%), Gaps = 16/327 (4%) Query: 5 SVLLHTGQKMPLIGLGTWKSEP---GQVKAAIKHALSAGYRHIDCASVYGNETEIGEALK 61 V L+ G MP++G GT+ + K A+ AG+RHID A +Y NE ++G A++ Sbjct: 7 CVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQVGLAIR 66 Query: 62 ESVGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERG 121 + G +V RE++F TSKLW+T H PE V PAL +L QL+Y+DLYL+H P + + G Sbjct: 67 SKIADG-SVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLKPG 125 Query: 122 DNPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASV--R 179 + P + +G V +D TW+A+E GL K++G+SNFN RQ++ +L+ + + Sbjct: 126 EELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYK 185 Query: 180 PAVLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSS-DRAWRHPDEPVLLEEPVVLALA 238 P QVECHPY +++L+ C ++ + + AYS LGS D+ W P+ PVLLE+PV+ ALA Sbjct: 186 PVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPVLCALA 245 Query: 239 EKHGRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWRY 298 +KH R+PA I LR+Q+QR V+ + KS N RI QN+QVF+F + E+MK +D L++N Y Sbjct: 246 KKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLDRNLHY 305 Query: 299 IVPMITVDGKRVPRDAGHPLYPFNDPY 325 A HP YP++D Y Sbjct: 306 FNSDSF---------ASHPNYPYSDEY 323 >1DLA-A nrPDB Length = 314 Score = 439 bits (1130), Expect = e-124, Method: Composition-based stats. Identities = 163/324 (50%), Positives = 224/324 (69%), Gaps = 12/324 (3%) Query: 4 SSVLLHTGQKMPLIGLGTWKSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALKES 63 S ++L+TG KMP++GLGTWKS PG+V A+K A+ GYRHIDCA VY NE E+G L+E Sbjct: 1 SHLVLYTGAKMPILGLGTWKSPPGKVTEAVKVAIDLGYRHIDCAHVYQNENEVGLGLQEK 60 Query: 64 VGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDN 123 + G+ V RE+LF+ SKLW T H V+ A + TL DL+L+YLDLYL+HWP F+ G + Sbjct: 61 L-QGQVVKREDLFIVSKLWCTDHEKNLVKGACQTTLRDLKLDYLDLYLIHWPTGFKPGKD 119 Query: 124 PFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVR--PA 181 PFP + DG V D + + ETW+A+E LV +GLVKA+G+SNFN Q++ +L+ ++ PA Sbjct: 120 PFPLDGDGNVVPDESDFVETWEAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYKPA 179 Query: 182 VLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEKH 241 V Q+E HPYL Q +LI +C ++G+ VTAYSPLGS DR W P++P LLE+P + A+A K+ Sbjct: 180 VNQIEVHPYLTQEKLIEYCKSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAKY 239 Query: 242 GRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWRYIVP 301 ++ AQ+L+R+ +QR +I IPKS+ P RI +N QVFDF SPE+M L + N+NWR Sbjct: 240 NKTTAQVLIRFPMQRNLIVIPKSVTPERIAENFQVFDFELSPEDMNTLLSYNRNWRVCAL 299 Query: 302 MITVDGKRVPRDAGHPLYPFNDPY 325 M A H YPF++ Y Sbjct: 300 MSC---------ASHKDYPFHEEY 314 >3RX4-A nrPDB Length = 336 Score = 439 bits (1128), Expect = e-123, Method: Composition-based stats. Identities = 158/325 (48%), Positives = 220/325 (67%), Gaps = 12/325 (3%) Query: 3 ASSVLLHTGQKMPLIGLGTWKSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALKE 62 AS +LL+ G KMP++GLGTWKS PGQV A+K A+ GYRHIDCA VY NE E+G A++E Sbjct: 22 ASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQE 81 Query: 63 SVGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGD 122 + + V REELF+ SKLW T H V+ A +KTL+DL+L+YLDLYL+HWP F+ G Sbjct: 82 KLRE-QVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGK 140 Query: 123 NPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVR--P 180 FP + G V T+ +TW A+E LV +GLVKA+G+SNFN Q++ +L+ ++ P Sbjct: 141 EFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKP 200 Query: 181 AVLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEK 240 AV Q+ECHPYL Q +LI +C ++G+ VTAYSPLGS DR W P++P LLE+P + A+A K Sbjct: 201 AVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAK 260 Query: 241 HGRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWRYIV 300 H ++ AQ+L+R+ +QR ++ IPKS+ P RI +N +VFDF S ++M L + N+NWR Sbjct: 261 HNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCA 320 Query: 301 PMITVDGKRVPRDAGHPLYPFNDPY 325 + H YPF++ + Sbjct: 321 LLSC---------TSHKDYPFHEEF 336 >3G1R-A nrPDB Length = 346 Score = 437 bits (1124), Expect = e-123, Method: Composition-based stats. Identities = 138/331 (41%), Positives = 207/331 (62%), Gaps = 17/331 (5%) Query: 2 TASSVLLHTGQKMPLIGLGTWK----SEPGQVKAAIKHALSAGYRHIDCASVYGNETEIG 57 + + L G +P+IGLGT+ + G ++K A+ GYRHID A +Y NE E+G Sbjct: 26 ASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVG 85 Query: 58 EALKESVGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYA 117 EA++E + GK V RE++F KLW T H PE V P L +TL LQL+Y+DLY++ P A Sbjct: 86 EAIREKIAEGK-VRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMA 144 Query: 118 FERGDNPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVAS 177 F+ GD +P++ +G Y ++ TW+A+E GLVK+LG+SNFN RQ++ +L+ Sbjct: 145 FKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPG 204 Query: 178 V--RPAVLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRA-WRHPDEPVLLEEPVV 234 + +P QVECHPY Q +L+ C + +TAYSPLG+S W + P LL++ ++ Sbjct: 205 LKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALL 264 Query: 235 LALAEKHGRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNK 294 +L +++ ++ AQI+LR+ +QR V+ IPKS N RI +N Q+FDF+ + EEMK ++ALNK Sbjct: 265 NSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNK 324 Query: 295 NWRYIVPMITVDGKRVPRDAGHPLYPFNDPY 325 N R++ ++ D HP YPF+D Y Sbjct: 325 NVRFVELLMWRD---------HPEYPFHDEY 346 >2HE8-A nrPDB Length = 323 Score = 437 bits (1123), Expect = e-123, Method: Composition-based stats. Identities = 131/327 (40%), Positives = 197/327 (60%), Gaps = 16/327 (4%) Query: 5 SVLLHTGQKMPLIGLGT---WKSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALK 61 V+L+ G +P++G GT + + K K A+ AG+ H D ASVY E +GEA++ Sbjct: 7 CVILNDGNFIPVLGFGTALPLECPKSKAKELTKIAIDAGFHHFDSASVYNTEDHVGEAIR 66 Query: 62 ESVGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERG 121 + G V RE++F TSK+W T HPE V +L ++L LQ +Y+DLYL+H+P A + G Sbjct: 67 SKIADG-TVRREDIFYTSKVWCTSLHPELVRASLERSLQKLQFDYVDLYLIHYPMALKPG 125 Query: 122 DNPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASV--R 179 + FP + G + +D TW+A+E GL K++G+SNFN RQ++ +L+ + + Sbjct: 126 EENFPVDEHGKLIFDRVDLCATWEAMEKCKDAGLTKSIGVSNFNYRQLEMILNKPGLKYK 185 Query: 180 PAVLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDR-AWRHPDEPVLLEEPVVLALA 238 P QVECHPYL Q +L+ C ++ + + AY LG+ W + PVLL+EPV+ ++A Sbjct: 186 PVCNQVECHPYLNQMKLLDFCKSKDIVLVAYGVLGTQRYGGWVDQNSPVLLDEPVLGSMA 245 Query: 239 EKHGRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWRY 298 +K+ R+PA I LR+Q+QR ++ + S+ RI +N+QVF+F S E+MK LD LN+N RY Sbjct: 246 KKYNRTPALIALRYQLQRGIVVLNTSLKEERIKENMQVFEFQLSSEDMKVLDGLNRNMRY 305 Query: 299 IVPMITVDGKRVPRDAGHPLYPFNDPY 325 I I GHP +PF D Y Sbjct: 306 IPAAIF---------KGHPNWPFLDEY 323 >1AFS-A nrPDB Length = 323 Score = 431 bits (1109), Expect = e-121, Method: Composition-based stats. Identities = 128/325 (39%), Positives = 200/325 (61%), Gaps = 16/325 (4%) Query: 6 VLLHTGQKMPLIGLGTW---KSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALKE 62 V L+ G +P++G GT K +V A K A+ G+RH D A +Y E E+G+A++ Sbjct: 8 VALNDGNFIPVLGFGTTVPEKVAKDEVIKATKIAIDNGFRHFDSAYLYEVEEEVGQAIRS 67 Query: 63 SVGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGD 122 + G V RE++F TSKLW+T H PE V L KTL QL+Y+DLY++H+P A + GD Sbjct: 68 KIEDG-TVKREDIFYTSKLWSTFHRPELVRTCLEKTLKSTQLDYVDLYIIHFPMALQPGD 126 Query: 123 NPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASV--RP 180 FP++ G + +++ +TW+A+E GL K++G+SNFN RQ++ +L+ + +P Sbjct: 127 IFFPRDEHGKLLFETVDICDTWEAMEKCKDAGLAKSIGVSNFNCRQLERILNKPGLKYKP 186 Query: 181 AVLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSS-DRAWRHPDEPVLLEEPVVLALAE 239 QVECH YL Q++++ +C ++ + + +Y LGSS D+ W PVLL++PV+ A+A+ Sbjct: 187 VCNQVECHLYLNQSKMLDYCKSKDIILVSYCTLGSSRDKTWVDQKSPVLLDDPVLCAIAK 246 Query: 240 KHGRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWRYI 299 K+ ++PA + LR+Q+QR V+ + +S N RI + QVF+F + E+MK LD LN+N+RY Sbjct: 247 KYKQTPALVALRYQLQRGVVPLIRSFNAKRIKELTQVFEFQLASEDMKALDGLNRNFRYN 306 Query: 300 VPMITVDGKRVPRDAGHPLYPFNDP 324 D HP +PF D Sbjct: 307 NAKYFDD---------HPNHPFTDE 322 >5UXF-A nrPDB Length = 342 Score = 431 bits (1109), Expect = e-121, Method: Composition-based stats. Identities = 137/327 (41%), Positives = 200/327 (61%), Gaps = 16/327 (4%) Query: 5 SVLLHTGQKMPLIGLGTWKS---EPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALK 61 V L+ G +P +G GT+K + A AL GYRH+D A Y E EIG+A++ Sbjct: 26 CVKLNDGHLIPALGFGTYKPKEVPKSKSLEAACLALDVGYRHVDTAYAYQVEEEIGQAIQ 85 Query: 62 ESVGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERG 121 ++ +G V RE+LFVT+KLW T PE V+PAL K+L LQL+Y+DLY+MH+P + G Sbjct: 86 SAIAAG-VVKREDLFVTTKLWCTCFRPELVKPALEKSLKKLQLDYVDLYIMHYPVPMKSG 144 Query: 122 DNPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASV--R 179 DN FP N G D+ + +TW+ LE GLVK++G+SNFN RQ++ +L+ + + Sbjct: 145 DNDFPVNEQGKSLLDTVDFCDTWERLEECKDAGLVKSIGVSNFNHRQLERILNKPGLKYK 204 Query: 180 PAVLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSD-RAWRHPDEPVLLEEPVVLALA 238 P QVECH YL Q +L+ +C ++ + + AY LG+ + W + PVLL +PV+ +A Sbjct: 205 PVCNQVECHLYLNQRKLLDYCESKDIVLVAYGALGTQRYKEWVDQNSPVLLNDPVLCDVA 264 Query: 239 EKHGRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWRY 298 +K+ RSPA I LR+ +QR ++ + +S + + +N+QVF F SPE+MK LD LNKN+RY Sbjct: 265 KKNKRSPALIALRYLIQRGIVPLAQSFKENEMRENLQVFGFQLSPEDMKTLDGLNKNFRY 324 Query: 299 IVPMITVDGKRVPRDAGHPLYPFNDPY 325 + VD HP YPF + Y Sbjct: 325 LPAEFLVD---------HPEYPFVEEY 342 >1C9W-A nrPDB Length = 315 Score = 427 bits (1097), Expect = e-120, Method: Composition-based stats. Identities = 156/316 (49%), Positives = 217/316 (68%), Gaps = 3/316 (0%) Query: 3 ASSVLLHTGQKMPLIGLGTWKSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALKE 62 ++ V L T KMP++GLGTW+S PGQVK A+K A+ AGYRHIDCA Y NE E+GEA++E Sbjct: 1 STFVELSTKAKMPIVGLGTWQSPPGQVKEAVKVAIDAGYRHIDCAYAYYNEHEVGEAIQE 60 Query: 63 SVGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGD 122 + KAV RE+LF+ SKLW T + ++ A +KTL DL+L+YLDLYL+HWP + G Sbjct: 61 KIKE-KAVRREDLFIVSKLWPTCFERKLLKEAFQKTLTDLKLDYLDLYLIHWPQGLQPGK 119 Query: 123 NPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVR--P 180 FPK+ G V + + W+ +E LV +GLVKALG+SNFN QI+ +L+ ++ P Sbjct: 120 ELFPKDDQGNVLTSKITFLDAWEVMEELVDEGLVKALGVSNFNHFQIERILNKPGLKHKP 179 Query: 181 AVLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEK 240 QVECHPYL Q +LI +CH++G+ VTAYSPLGS +R W P++P LLE+P + +A K Sbjct: 180 VTNQVECHPYLTQEKLIEYCHSKGITVTAYSPLGSPNRPWAKPEDPSLLEDPKIKEIAAK 239 Query: 241 HGRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWRYIV 300 H ++ AQ+L+R+ +QR V+ IPKS+ P+RI +N QVFDF S +EM + N+NWR + Sbjct: 240 HKKTSAQVLIRFHIQRNVVVIPKSVTPARIHENFQVFDFQLSDQEMATILGFNRNWRACL 299 Query: 301 PMITVDGKRVPRDAGH 316 TV+ + P DA + Sbjct: 300 LPETVNMEEYPYDAEY 315 >1FRB-A nrPDB Length = 315 Score = 423 bits (1089), Expect = e-119, Method: Composition-based stats. Identities = 161/316 (50%), Positives = 218/316 (68%), Gaps = 3/316 (0%) Query: 3 ASSVLLHTGQKMPLIGLGTWKSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALKE 62 A+ V L T KMP++GLGTWKS P QVK A+K A+ AGYRHIDCA Y NE E+GEA++E Sbjct: 1 ATFVELSTKAKMPIVGLGTWKSPPNQVKEAVKAAIDAGYRHIDCAYAYCNENEVGEAIQE 60 Query: 63 SVGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGD 122 + KAV RE+LF+ SKLW T + ++ A +KTL DL+L+YLDLYL+HWP + G Sbjct: 61 KIKE-KAVQREDLFIVSKLWPTCFEKKLLKEAFQKTLTDLKLDYLDLYLIHWPQGLQPGK 119 Query: 123 NPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVR--P 180 FPK+ G + T + E W+ +E LV +GLVKALG+SNFN QI+ +L+ ++ P Sbjct: 120 ELFPKDDQGRILTSKTTFLEAWEGMEELVDQGLVKALGVSNFNHFQIERLLNKPGLKHKP 179 Query: 181 AVLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEK 240 QVECHPYL Q +LI +CH++G+ VTAYSPLGS DR P++P LLE+P + +A K Sbjct: 180 VTNQVECHPYLTQEKLIQYCHSKGISVTAYSPLGSPDRPSAKPEDPSLLEDPKIKEIAAK 239 Query: 241 HGRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWRYIV 300 H ++ AQ+L+R+ +QR V+ IPKS+ PSRI +NIQVFDF S EEM + + N+NWR + Sbjct: 240 HEKTSAQVLIRFHIQRNVVVIPKSVTPSRIQENIQVFDFQLSDEEMATILSFNRNWRACL 299 Query: 301 PMITVDGKRVPRDAGH 316 TV+ + P DA + Sbjct: 300 LPETVNMEEYPYDAEY 315 >4HBK-A nrPDB Length = 344 Score = 422 bits (1084), Expect = e-118, Method: Composition-based stats. Identities = 146/320 (45%), Positives = 212/320 (66%), Gaps = 13/320 (4%) Query: 6 VLLHTGQKMPLIGLGTWKSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALKESVG 65 + ++ G+ +P+IGLGTW S PG+V AA+K AL GYRH+DCA VY NE EIGEAL+ ++ Sbjct: 38 LKMNNGRSIPVIGLGTWNSPPGEVGAAVKKALEIGYRHLDCAYVYRNEAEIGEALENALN 97 Query: 66 SGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPF 125 S + + RE++F+TSKLWNT PE V A +TL +L+L YLDLYL+HWP + G + F Sbjct: 98 SLR-LKREDIFITSKLWNTFFRPEHVRKACEETLKNLRLNYLDLYLIHWPVPLKHGGDLF 156 Query: 126 PKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVRPAVLQV 185 P +++G + D+ +++TWK +E LV +GLVK++GLSNFN RQI ++L ++PA LQ+ Sbjct: 157 PTDSNGQLCLDNVPHEDTWKEMEKLVDEGLVKSIGLSNFNKRQIQNILEHCRIKPANLQI 216 Query: 186 ECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEKHGRSP 245 E H +L+ + + GL VTAY+PLGS + P + LL +P VL +A +H ++P Sbjct: 217 EIHANFPNIKLVEYAQSVGLTVTAYAPLGSPAHS---PGKVNLLTKPCVLEIAHRHKKTP 273 Query: 246 AQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWRYIVPMITV 305 AQ+LLR+ +QRK+I +PKS+ RI +N QVFDF S EEM +L+ + N R + Sbjct: 274 AQVLLRYLLQRKLIVVPKSVTFKRIEENFQVFDFQLSNEEMHELNTESLNERQFTLL--- 330 Query: 306 DGKRVPRDAGHPLYPFNDPY 325 + +GH YPF + Y Sbjct: 331 ------QMSGHQEYPFKEEY 344 >3O3R-A nrPDB Length = 316 Score = 418 bits (1076), Expect = e-117, Method: Composition-based stats. Identities = 158/324 (48%), Positives = 219/324 (67%), Gaps = 12/324 (3%) Query: 4 SSVLLHTGQKMPLIGLGTWKSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALKES 63 + V L T KMPL+GLGTWKS PGQVK A+K A+ AGYRH DCA VY NE+E+GEA++E Sbjct: 3 TFVKLRTKAKMPLVGLGTWKSPPGQVKEAVKAAIDAGYRHFDCAYVYQNESEVGEAIQEK 62 Query: 64 VGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDN 123 + KAV RE+LF+ SKLW+T ++ A +KTL+DL+L+YLDLYL+HWP + G Sbjct: 63 IKE-KAVRREDLFIVSKLWSTFFEKSLMKEAFQKTLSDLKLDYLDLYLIHWPQGLQAGKE 121 Query: 124 PFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVR--PA 181 PK++ G V + + + W+ +E LV +GLVKALG+SNFN QI+ +L+ ++ P Sbjct: 122 FLPKDSQGKVLMSKSTFLDAWEGMEELVDQGLVKALGVSNFNHFQIERLLNKPGLKHKPV 181 Query: 182 VLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEKH 241 QVECHPYL Q +LI +CH++G+ V AYSPLGS DR + P++PV+LE P + +A KH Sbjct: 182 TNQVECHPYLTQEKLIQYCHSKGIAVIAYSPLGSPDRPYAKPEDPVVLEIPKIKEIAAKH 241 Query: 242 GRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWRYIVP 301 ++ AQ+L+R+ VQR V IPKS+ S I +NIQVFDF S E+M + +LN+NWR Sbjct: 242 KKTIAQVLIRFHVQRNVAVIPKSVTLSHIKENIQVFDFQLSEEDMAAILSLNRNWRACGL 301 Query: 302 MITVDGKRVPRDAGHPLYPFNDPY 325 +T D + +PF++ Y Sbjct: 302 FVTSDEE---------DFPFHEEY 316 >5ZCM-A nrPDB Length = 341 Score = 397 bits (1021), Expect = e-111, Method: Composition-based stats. Identities = 127/320 (39%), Positives = 193/320 (60%), Gaps = 11/320 (3%) Query: 5 SVLLHTGQKMPLIGLGTWKSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALKESV 64 S+ L++G +MPL+G G WK + + +A+ GYR D A YGN EIGE + ++ Sbjct: 23 SIKLNSGYEMPLVGFGCWKVDNATCADTVYNAIKVGYRLFDAAMDYGNCKEIGEGINRAL 82 Query: 65 GSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFE----- 119 G V R+ELF+TSKLWN+ H P++VE AL+K L+D++L+Y+DL+L+H+P AF+ Sbjct: 83 DEG-LVARDELFITSKLWNSYHDPKNVELALKKVLSDMKLDYIDLFLIHFPIAFKFVPFE 141 Query: 120 -RGDNPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASV 178 + F Y+ ETWKA+E L G K++G+SNF++ I D+L A + Sbjct: 142 EKYPPAFYCGDGDNFHYEDVPLLETWKAMEKLTKGGKAKSIGISNFSAALIYDLLRGAEI 201 Query: 179 RPAVLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSD----RAWRHPDEPVLLEEPVV 234 +PAVLQ+E HPYL Q LI + ++G+ +TAYS G + + D P L E + Sbjct: 202 KPAVLQIEHHPYLQQPRLIEYVQSQGIAITAYSSFGPQSFLELKHSKALDTPTLFEHKTI 261 Query: 235 LALAEKHGRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNK 294 ++A+K+ ++PAQ+LLRW QR + IPKS NP R+LQN++V DF S E+ ++ L++ Sbjct: 262 TSIADKYKKTPAQVLLRWASQRDIAIIPKSNNPDRLLQNLEVNDFNLSKEDFDEISKLDQ 321 Query: 295 NWRYIVPMITVDGKRVPRDA 314 + R+ P R+P A Sbjct: 322 DLRFNNPWDWDTKNRIPIFA 341 >5JH1-A nrPDB Length = 309 Score = 397 bits (1020), Expect = e-111, Method: Composition-based stats. Identities = 135/292 (46%), Positives = 195/292 (66%), Gaps = 10/292 (3%) Query: 3 ASSVLLHTGQKMPLIGLGTWKSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALKE 62 A +L+TG K+P +GLG+W+S+PG V A+ A+ AGYRHIDCA VYGNE EIG ALK+ Sbjct: 1 ARHFVLNTGAKIPSVGLGSWQSDPGVVGNAVYAAVKAGYRHIDCARVYGNEKEIGLALKK 60 Query: 63 SVGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGD 122 G V RE++F+TSKLWN H PEDV AL +L DLQLEYLDLYL+HWP+ ++G Sbjct: 61 LFEEG-VVKREDMFITSKLWNDHHAPEDVPEALNDSLNDLQLEYLDLYLIHWPFRVKKGT 119 Query: 123 NPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVRPAV 182 N P+N + + + TW A+E L G +A+G+SNF+S+++ D+L+VA V PAV Sbjct: 120 NTSPEN------FVTPDFPATWGAMEKLYDAGKARAIGVSNFSSKKLGDLLAVARVPPAV 173 Query: 183 LQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEKHG 242 QVECHP Q +L + C + G+ +TAYSPLGS W + + +L+EP+++++AEK G Sbjct: 174 DQVECHPGWQQTKLHSFCQSTGVHLTAYSPLGSPGTTWMNGN---VLKEPIIISIAEKLG 230 Query: 243 RSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNK 294 ++ AQ+ LRW +Q +PKS N RI QN+ V+D++ + + + + + Sbjct: 231 KTSAQVALRWNIQMGHSVLPKSTNEERIKQNLDVYDWSIPDDLLAKFSEIKQ 282 >3H7U-A nrPDB Length = 335 Score = 397 bits (1020), Expect = e-111, Method: Composition-based stats. Identities = 131/318 (41%), Positives = 184/318 (57%), Gaps = 10/318 (3%) Query: 2 TASSVLLHTGQKMPLIGLGTWKSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALK 61 + L+TG K P +GLGTW++ PG V A+ A+ GYRHIDCA +YGNE EIG LK Sbjct: 24 AITFFKLNTGAKFPSVGLGTWQASPGLVGDAVAAAVKIGYRHIDCAQIYGNEKEIGAVLK 83 Query: 62 ESVGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERG 121 + + V RE+LF+TSKLW T H P+DV AL +TL DLQLEY+DLYL+HWP ++G Sbjct: 84 KLFED-RVVKREDLFITSKLWCTDHDPQDVPEALNRTLKDLQLEYVDLYLIHWPARIKKG 142 Query: 122 DNPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVRPA 181 TWKA+E L G +A+G+SNF+++++ D+L +A V PA Sbjct: 143 SVGIKPEN-----LLPVDIPSTWKAMEALYDSGKARAIGVSNFSTKKLADLLELARVPPA 197 Query: 182 VLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEKH 241 V QVECHP Q +L C ++G+ ++AYSPLGS W D +L+ P++ +AEK Sbjct: 198 VNQVECHPSWRQTKLQEFCKSKGVHLSAYSPLGSPGTTWLKSD---VLKNPILNMVAEKL 254 Query: 242 GRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWRYIVP 301 G+SPAQ+ LRW +Q +PKS N RI +N VFD++ + + + R + Sbjct: 255 GKSPAQVALRWGLQMGHSVLPKSTNEGRIKENFNVFDWSIPDYMFAKFAEIEQ-ARLVTG 313 Query: 302 MITVDGKRVPRDAGHPLY 319 V P + L+ Sbjct: 314 SFLVHETLSPYKSIEELW 331 >5Z6T-A nrPDB Length = 343 Score = 395 bits (1014), Expect = e-110, Method: Composition-based stats. Identities = 123/312 (39%), Positives = 175/312 (56%), Gaps = 11/312 (3%) Query: 4 SSVLLHTGQKMPLIGLGTWKSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALKES 63 S+ L++G MP +G G WK + I A+ GYR D A Y NE +G +K++ Sbjct: 27 PSIKLNSGYDMPAVGFGCWKVDVDTCSEQIYRAIKTGYRLFDGAEDYANEKLVGAGVKKA 86 Query: 64 VGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFE---- 119 + G V RE+LF+TSKLWN HHP++VE AL +TL+DLQ++Y+DL+L+H+P F+ Sbjct: 87 IDEG-IVKREDLFLTSKLWNNYHHPDNVEKALNRTLSDLQVDYVDLFLIHFPVTFKFVPL 145 Query: 120 --RGDNPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVAS 177 + F Y+ ETWKALE LV G ++++G+SNF + D+L A+ Sbjct: 146 EEKYPPGFYCGKGDNFDYEDVPILETWKALEKLVKAGKIRSIGVSNFPGALLLDLLRGAT 205 Query: 178 VRPAVLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSD----RAWRHPDEPVLLEEPV 233 ++P+VLQVE HPYL Q LI +RG+ VTAYS G R + L E Sbjct: 206 IKPSVLQVEHHPYLQQPRLIEFAQSRGIAVTAYSSFGPQSFVELNQGRALNTSPLFENET 265 Query: 234 VLALAEKHGRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALN 293 + A+A KHG+SPAQ+LLRW QR + IPKS R+L+N V F ++ + L+ Sbjct: 266 IKAIAAKHGKSPAQVLLRWSSQRGIAIIPKSNTVPRLLENKDVNSFDLDEQDFADIAKLD 325 Query: 294 KNWRYIVPMITV 305 N R+ P Sbjct: 326 INLRFNDPWDWD 337 >1K8C-A nrPDB Length = 322 Score = 390 bits (1002), Expect = e-109, Method: Composition-based stats. Identities = 123/315 (39%), Positives = 178/315 (56%), Gaps = 11/315 (3%) Query: 2 TASSVLLHTGQKMPLIGLGTWKSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALK 61 + + L +G MP IG G WK + A+ AGYR D A YGNE E+G+ +K Sbjct: 4 SIPDIKLSSGHLMPSIGFGCWKLANATAGEQVYQAIKAGYRLFDGAEDYGNEKEVGDGVK 63 Query: 62 ESVGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFE-- 119 ++ G V REE+F+TSKLWN H P++VE AL KTLADL+++Y+DL+L+H+P AF+ Sbjct: 64 RAIDEG-LVKREEIFLTSKLWNNYHDPKNVETALNKTLADLKVDYVDLFLIHFPIAFKFV 122 Query: 120 ----RGDNPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSV 175 + F Y+ ETWKALE LVA G +K++G+SNF + D+L Sbjct: 123 PIEEKYPPGFYCGDGNNFVYEDVPILETWKALEKLVAAGKIKSIGVSNFPGALLLDLLRG 182 Query: 176 ASVRPAVLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSD----RAWRHPDEPVLLEE 231 A+++PAVLQVE HPYL Q +LI G+ +TAYS G R + P L Sbjct: 183 ATIKPAVLQVEHHPYLQQPKLIEFAQKAGVTITAYSSFGPQSFVEMNQGRALNTPTLFAH 242 Query: 232 PVVLALAEKHGRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDA 291 + A+A K+ ++PA++LLRW QR + IPKS P R++QN F + E+ +++ Sbjct: 243 DTIKAIAAKYNKTPAEVLLRWAAQRGIAVIPKSNLPERLVQNRSFNTFDLTKEDFEEIAK 302 Query: 292 LNKNWRYIVPMITVD 306 L+ R+ P + Sbjct: 303 LDIGLRFNDPWDWDN 317 >3WCZ-A nrPDB Length = 308 Score = 382 bits (980), Expect = e-106, Method: Composition-based stats. Identities = 125/326 (38%), Positives = 190/326 (58%), Gaps = 27/326 (8%) Query: 1 MTASSVLLHTGQKMPLIGLGTWKSEP------GQVKAAIKHALSAGYRHIDCASVYGNET 54 + A + L+ G +P++ LGT + +V+ A+ A+ AGYRHID A+VY +E Sbjct: 3 VQAPCIQLNDGNTIPIVALGTGRGTAKESDSIDEVRQAVYWAIEAGYRHIDTAAVYQDEE 62 Query: 55 EIGEALKESVGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHW 114 ++G+ + E++ +G V REELFVT+KLWN KH + V PAL+++L L L+Y+DLYL+H+ Sbjct: 63 QVGQGIAEAIANG-LVTREELFVTTKLWNDKHARDQVVPALQESLKKLGLDYIDLYLIHF 121 Query: 115 PYAFERGDNPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLS 174 P A + D+P D+ Y ETW+ ++ GL +++G+SNFN+ QI ++S Sbjct: 122 PIATKPDDSP-----------DNIDYLETWQGMQDARQLGLARSIGVSNFNATQITRLVS 170 Query: 175 VASVRPAVLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVV 234 + +RP + Q+E +P Q L+AHC + G+ V AYSP G + P ++P + Sbjct: 171 NSYIRPVINQIEVNPTNTQEPLVAHCQSLGIAVMAYSPFGFVVSRGQTGAPPPRSDDPTL 230 Query: 235 LALAEKHGRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNK 294 ALA K+ +S QILLR+ + R +I IPKS N RI QNI +FDF + EE+ ++ NK Sbjct: 231 TALANKYRKSVGQILLRYLIDRGLIPIPKSTNKQRIAQNIDLFDFQLTFEEVAAINQFNK 290 Query: 295 NWRYIVPMITVDGKRVPRDAGHPLYP 320 N R I D +P YP Sbjct: 291 NHRVIDISDWKD---------YPNYP 307 >3H7R-A nrPDB Length = 331 Score = 370 bits (950), Expect = e-103, Method: Composition-based stats. Identities = 126/286 (44%), Positives = 179/286 (62%), Gaps = 15/286 (5%) Query: 1 MTAS--SVLLHTGQKMPLIGLGTWKSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGE 58 M A L+TG K+P +GLGT+ V AI+ A+ GYRHIDCAS+YGNE EIG Sbjct: 21 MAAPIRFFELNTGAKLPCVGLGTY----AMVATAIEQAIKIGYRHIDCASIYGNEKEIGG 76 Query: 59 ALKESVGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAF 118 LK+ +G G V REELF+TSKLW+ H PEDV AL KTL DLQ++Y+DLYL+HWP + Sbjct: 77 VLKKLIGDG-FVKREELFITSKLWSNDHLPEDVPKALEKTLQDLQIDYVDLYLIHWPASL 135 Query: 119 ERGDNPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASV 178 ++ ++ P TWKA+E L G +A+G+SNF+S+++ D+L+VA V Sbjct: 136 KK-ESLMPTPE----MLTKPDITSTWKAMEALYDSGKARAIGVSNFSSKKLTDLLNVARV 190 Query: 179 RPAVLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALA 238 PAV QVECHP Q L C ++G+ ++ YSPLGS + +L+ P+V +A Sbjct: 191 TPAVNQVECHPVWQQQGLHELCKSKGVHLSGYSPLGSQSKGEVRLK---VLQNPIVTEVA 247 Query: 239 EKHGRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPE 284 EK G++ AQ+ LRW +Q +PKS + +R+ +N+ VFD++ + Sbjct: 248 EKLGKTTAQVALRWGLQTGHSVLPKSSSGARLKENLDVFDWSIPED 293 >4GIE-A nrPDB Length = 290 Score = 368 bits (946), Expect = e-102, Method: Composition-based stats. Identities = 112/296 (37%), Positives = 170/296 (57%), Gaps = 33/296 (11%) Query: 4 SSVLLHTGQKMPLIGLGTWKSEPG-QVKAAIKHALSAGYRHIDCASVYGNETEIGEALKE 62 + V LH +MP +GLG W+++ G + A++ A+ AGYRHID A +Y NE +G+ ++E Sbjct: 14 NCVTLHNSVRMPQLGLGVWRAQDGAETANAVRWAIEAGYRHIDTAYIYSNERGVGQGIRE 73 Query: 63 SVGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGD 122 S VPREE++VT+K+WN+ E A ++ L LEY+DLYL+HWP + Sbjct: 74 S-----GVPREEVWVTTKVWNSDQGYEKTLAAFERSRELLGLEYIDLYLIHWPGKKK--- 125 Query: 123 NPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVRPAV 182 + +TWKALE L + V+A+G+SNF + ++ +RP V Sbjct: 126 -----------------FVDTWKALEKLYEEKKVRAIGVSNFEPHHLTELFKSCKIRPMV 168 Query: 183 LQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEKHG 242 QVE HP Q L C + +TA+SPLGS +E +L+ V+ +A+KH Sbjct: 169 NQVELHPLFQQRTLREFCKQHNIAITAWSPLGSG-------EEAGILKNHVLGEIAKKHN 221 Query: 243 RSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWRY 298 +SPAQ+++RW +Q ++ IPKS N RI +N V+DF + EEM+Q+D LN++ R Sbjct: 222 KSPAQVVIRWDIQHGIVTIPKSTNKGRIQENFNVWDFKLTEEEMRQIDELNEDKRI 277 >3KRB-A nrPDB Length = 334 Score = 367 bits (942), Expect = e-102, Method: Composition-based stats. Identities = 121/302 (40%), Positives = 178/302 (58%), Gaps = 12/302 (3%) Query: 15 PLIGLGTWKSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEAL-KESVGSGKAVPRE 73 P +G GTW++ P V+ A++ AL GYRHIDCA VY NE IG A K + + RE Sbjct: 26 PRLGFGTWQAPPEAVQTAVETALMTGYRHIDCAYVYQNEEAIGRAFGKIFKDASSGIKRE 85 Query: 74 ELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGD--NPFPKNADG 131 ++++TSKLWN H PE V +KT++DLQ++YLDL+L+HWP AF R D + FPK+A+G Sbjct: 86 DVWITSKLWNYNHRPELVREQCKKTMSDLQVDYLDLFLVHWPLAFVRNDVGDLFPKDAEG 145 Query: 132 TVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVRPAVLQVECHPYL 191 + +TW+A+E LV +GLVK +G+SN+ + D+L+ A ++P V Q+E HP+ Sbjct: 146 RAMLEKVPLADTWRAMEQLVEEGLVKHIGVSNYTVPLLADLLNYAKIKPLVNQIEIHPWH 205 Query: 192 AQNELIAHCHARGLEVTAYSPLGSSDRAWRHPD---EPVLLEEPVVLALAEKHGRSPAQI 248 + + C G+ VTAYSP+G S R P + V+LE + A+A+ G SP + Sbjct: 206 PNDATVKFCLDNGIGVTAYSPMGGSYADPRDPSGTQKNVILECKTLKAIADAKGTSPHCV 265 Query: 249 LLRWQVQR----KVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDA--LNKNWRYIVPM 302 L W V++ IPKS P+RI N + + S ++M ++ LNK R+ P Sbjct: 266 ALAWHVKKWNTSMYSVIPKSQTPARIEANFKCTEVQLSDDDMDAINNIHLNKRIRFCDPA 325 Query: 303 IT 304 I Sbjct: 326 IF 327 >1VBJ-A nrPDB Length = 281 Score = 366 bits (939), Expect = e-102, Method: Composition-based stats. Identities = 114/304 (37%), Positives = 170/304 (55%), Gaps = 37/304 (12%) Query: 5 SVLLHTGQKMPLIGLGTWKSEPG-QVKAAIKHALSAGYRHIDCASVYGNETEIGEALKES 63 S+ L G MP++G G WK + G + + A A+ +GYRHID A++Y NE G A+ Sbjct: 11 SLKLSNGVMMPVLGFGMWKLQDGNEAETATMWAIKSGYRHIDTAAIYKNEESAGRAIAS- 69 Query: 64 VGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDN 123 VPREELFVT+KLWN+ E A K++ L LEY+DLYL+HWP + Sbjct: 70 ----CGVPREELFVTTKLWNSDQGYESTLSAFEKSIKKLGLEYVDLYLIHWPGKDK---- 121 Query: 124 PFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVRPAVL 183 + +TWKA E L A V+A+G+SNF+ I+++L V P V Sbjct: 122 ----------------FIDTWKAFEKLYADKKVRAIGVSNFHEHHIEELLKHCKVAPMVN 165 Query: 184 QVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEKHGR 243 Q+E HP L Q L +C ++ + VTA+SPLG L+E+ + A+ K+G+ Sbjct: 166 QIELHPLLNQKALCEYCKSKNIAVTAWSPLGQGH----------LVEDARLKAIGGKYGK 215 Query: 244 SPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWRY-IVPM 302 + AQ++LRW++Q VI IPKS N +RI +N +FDF + E+++ +D +N RY P Sbjct: 216 TAAQVMLRWEIQAGVITIPKSGNEARIKENGNIFDFELTAEDIQVIDGMNAGHRYGPDPE 275 Query: 303 ITVD 306 + ++ Sbjct: 276 VFMN 279 >4F40-A nrPDB Length = 288 Score = 365 bits (936), Expect = e-101, Method: Composition-based stats. Identities = 119/294 (40%), Positives = 174/294 (59%), Gaps = 28/294 (9%) Query: 6 VLLHTGQKMPLIGLGTWKSEPGQVKA-AIKHALSAGYRHIDCASVYGNETEIGEALKESV 64 V L G KMP GLG W+S G+V A+K AL AGYRHID A++Y NE +G L+ S Sbjct: 13 VTLSNGVKMPQFGLGVWQSPAGEVTENAVKWALCAGYRHIDTAAIYKNEESVGAGLRAS- 71 Query: 65 GSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNP 124 VPRE++F+T+KLWNT+ E A ++ L ++Y+DLYL+HWP RG + Sbjct: 72 ----GVPREDVFITTKLWNTEQGYESTLAAFEESRQKLGVDYIDLYLIHWP----RGKDI 123 Query: 125 FPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVRPAVLQ 184 K Y ++W+A E L + V+A+G+SNF+ ++DVL++ +V P V Q Sbjct: 124 LSKEGK--------KYLDSWRAFEQLYKEKKVRAIGVSNFHIHHLEDVLAMCTVTPMVNQ 175 Query: 185 VECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEKHGRS 244 VE HP Q +L A C A+ ++V A+SPLG LL P++ A+ K+ ++ Sbjct: 176 VELHPLNNQADLRAFCDAKQIKVEAWSPLGQGK----------LLSNPILSAIGAKYNKT 225 Query: 245 PAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWRY 298 AQ++LRW +Q+ +I IPKS++ RI +N +FDF E++ +DALN N RY Sbjct: 226 AAQVILRWNIQKNLITIPKSVHRERIEENADIFDFELGAEDVMSIDALNTNSRY 279 >2BGQ-A nrPDB Length = 344 Score = 361 bits (926), Expect = e-100, Method: Composition-based stats. Identities = 116/317 (36%), Positives = 178/317 (56%), Gaps = 15/317 (4%) Query: 4 SSVLLHTGQKMPLIGLGTWKSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALKES 63 +L +G MP +GLGTW++ + AGYRH+D A+ YG E E+G+ LK + Sbjct: 38 DHFVLKSGHAMPAVGLGTWRAGSDTAHSVRTAITEAGYRHVDTAAEYGVEKEVGKGLKAA 97 Query: 64 VGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDN 123 + +G + R++LFVTSK+W T PE V PAL TL DLQL+Y+DLY +HWP+ + G + Sbjct: 98 MEAG--IDRKDLFVTSKIWCTNLAPERVRPALENTLKDLQLDYIDLYHIHWPFRLKDGAH 155 Query: 124 PFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVRPAVL 183 P A + +D + WK +E LV GLVK +G+ N+ +++ +L A + PAV Sbjct: 156 -MPPEAGEVLEFD---MEGVWKEMENLVKDGLVKDIGVCNYTVTKLNRLLRSAKIPPAVC 211 Query: 184 QVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEKHGR 243 Q+E HP +++ C G+ +TAYSPLGSS++ H +PVV +A K + Sbjct: 212 QMEMHPGWKNDKIFEACKKHGIHITAYSPLGSSEKNLAH--------DPVVEKVANKLNK 263 Query: 244 SPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWRYIV-PM 302 +P Q+L++W +QR IPKS RI +NIQVF + E+ K L ++ R + Sbjct: 264 TPGQVLIKWALQRGTSVIPKSSKDERIKENIQVFGWEIPEEDFKVLCSIKDEKRVLTGEE 323 Query: 303 ITVDGKRVPRDAGHPLY 319 + V+ P + ++ Sbjct: 324 LFVNKTHGPYRSARDVW 340 >1VP5-A nrPDB Length = 298 Score = 353 bits (906), Expect = 6e-98, Method: Composition-based stats. Identities = 96/295 (32%), Positives = 160/295 (54%), Gaps = 30/295 (10%) Query: 1 MTASSVLLHTGQKMPLIGLGTWKSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEAL 60 M V L+ G +MP++G G ++ P + + + A+ GYR ID A+ Y NE +G A+ Sbjct: 13 MQVPKVTLNNGVEMPILGYGVFQIPPEKTEECVYEAIKVGYRLIDTAASYMNEEGVGRAI 72 Query: 61 KESVGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFER 120 K ++ G V REELFVT+KLW + E + A K+L LQLEY+DLYL+H P+ Sbjct: 73 KRAIDEG-IVRREELFVTTKLWVSDVGYESTKKAFEKSLKKLQLEYIDLYLIHQPFGDVH 131 Query: 121 GDNPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVRP 180 WKA+E + GLV+A+G+SNF ++ D++ + P Sbjct: 132 C---------------------AWKAMEEMYKDGLVRAIGVSNFYPDRLMDLMVHHEIVP 170 Query: 181 AVLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEK 240 AV Q+E HP+ + E I ++ A+ P + + + V+ ++AEK Sbjct: 171 AVNQIEIHPFYQRQEEIEFMRNYNIQPEAWGPFAEGRK--------NIFQNGVLRSIAEK 222 Query: 241 HGRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKN 295 +G++ AQ++LRW Q+ ++ IPK++ R+ +NI +FDF + E+M+++ L++ Sbjct: 223 YGKTVAQVILRWLTQKGIVAIPKTVRRERMKENISIFDFELTQEDMEKIATLDEG 277 >1QWK-A nrPDB Length = 317 Score = 352 bits (904), Expect = 1e-97, Method: Composition-based stats. Identities = 123/332 (37%), Positives = 179/332 (53%), Gaps = 29/332 (8%) Query: 2 TASSVLLHTGQKMPLIGLGTWKSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALK 61 +S+ L G +MP+IGLGTW+S P +V A+K A+ AGYR ID ASVY NE IG A+K Sbjct: 4 ATASIKLSNGVEMPVIGLGTWQSSPAEVITAVKTAVKAGYRLIDTASVYQNEEAIGTAIK 63 Query: 62 ESVGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERG 121 E + G V REELF+T+K W + P +E LR++L LQLEY+DLYL H P AF Sbjct: 64 ELLEEG-VVKREELFITTKAWTHELAPGKLEGGLRESLKKLQLEYVDLYLAHMPAAFN-- 120 Query: 122 DNPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVRPA 181 D + ++ ++ W+ + + GL KA+G+SN+N+ QI L++ Sbjct: 121 --------DDMSEHIASPVEDVWRQFDAVYKAGLAKAVGVSNWNNDQISRALALGLTPVH 172 Query: 182 VLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRA---------WRHPDEPVLLEEP 232 QVE H Y Q++ + C + VT+Y+ LGS R P L++ Sbjct: 173 NSQVELHLYFPQHDHVDFCKKHNISVTSYATLGSPGRVNFTLPTGQKLDWAPAPSDLQDQ 232 Query: 233 VVLALAEKHGRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDAL 292 VLALAEK ++PAQ+LLR+ + R +PKSI +RI +N +VFDF+ + E++ +L+ Sbjct: 233 NVLALAEKTHKTPAQVLLRYALDRGCAILPKSIQENRIKENFEVFDFSLTEEDIAKLEES 292 Query: 293 NKNWRYIVPMITVDGKRVPRDAGHPLYPFNDP 324 + R + GHP F Sbjct: 293 KNSQRLFLQDF---------MTGHPEDAFAAE 315 >1MZR-A nrPDB Length = 296 Score = 345 bits (884), Expect = 2e-95, Method: Composition-based stats. Identities = 103/294 (35%), Positives = 161/294 (54%), Gaps = 33/294 (11%) Query: 4 SSVLLHTGQKMPLIGLGTWKSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALKES 63 + + L G MP +GLG W++ +V AI+ AL GYR ID A+ Y NE +G+ALK + Sbjct: 26 TVIKLQDGNVMPQLGLGVWQASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGKALKNA 85 Query: 64 VGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDN 123 +V REELF+T+KLWN H + AL +L LQL+Y+DLYLMHWP Sbjct: 86 -----SVNREELFITTKLWNDDH--KRPREALLDSLKKLQLDYIDLYLMHWPVP------ 132 Query: 124 PFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVRPAVL 183 HY E WK + L +GL+K++G+ NF + ++ V P + Sbjct: 133 ------------AIDHYVEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVIN 180 Query: 184 QVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEKHGR 243 Q+E HP + Q +L A ++ ++SPL + + ++ V+ LA+K+G+ Sbjct: 181 QIELHPLMQQRQLHAWNATHKIQTESWSPLAQGGKG--------VFDQKVIRDLADKYGK 232 Query: 244 SPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWR 297 +PAQI++RW + ++ IPKS+ PSRI +N V+DF +E+ ++ L++ R Sbjct: 233 TPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQGKR 286 >4MHB-A nrPDB Length = 297 Score = 334 bits (856), Expect = 3e-92, Method: Composition-based stats. Identities = 98/314 (31%), Positives = 167/314 (53%), Gaps = 41/314 (13%) Query: 5 SVLLHTGQKMPLIGLGTWK-SEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALKES 63 +V L+ G MPL+G G ++ + + + A+ A+ GYR ID A+ Y NET++G ALK S Sbjct: 17 TVKLNNGIAMPLLGFGVFQMTNTAECERAVIDAIETGYRLIDTAASYQNETQVGNALKLS 76 Query: 64 VGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDN 123 + R+ELF+T+KLW + E + ++L LQL+Y+DLYL+H PY G Sbjct: 77 -----GIARDELFITTKLWLQDTYYEGAKAQFERSLNRLQLDYVDLYLIHQPYGDVHG-- 129 Query: 124 PFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVRPAVL 183 W+A+E L G ++A+G+SNF+ ++ D+++ + PAV Sbjct: 130 -------------------AWRAMEELHQAGKIRAIGVSNFHPDRLADLMAFNKIIPAVN 170 Query: 184 QVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEKHGR 243 Q+E +P+ Q + +RG++ A++P L + PV+ A+ EK+G+ Sbjct: 171 QIEVNPFNQQLHAVPWMQSRGIQPEAWAPFAEGRNG--------LFQNPVLTAIGEKYGK 222 Query: 244 SPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNK------NWR 297 S Q++LRW QR ++ + KS+ R+ +NI + DF S E+M Q+ AL+ + R Sbjct: 223 SVGQVVLRWIFQRGIVSLAKSVRKGRMEENINILDFELSAEDMLQIAALDTATSAFFSHR 282 Query: 298 YIVPMITVDGKRVP 311 + + G+++ Sbjct: 283 DPAMVEWLTGRKLD 296 >3D3F-A nrPDB Length = 275 Score = 333 bits (855), Expect = 5e-92, Method: Composition-based stats. Identities = 122/296 (41%), Positives = 172/296 (58%), Gaps = 36/296 (12%) Query: 4 SSVLLHTGQKMPLIGLGTWKSEPG-QVKAAIKHALSAGYRHIDCASVYGNETEIGEALKE 62 +V LH G +MP GLG +K E G + ++K A+ GYR ID A++Y NE +G +KE Sbjct: 6 DTVKLHNGVEMPWFGLGVFKVENGNEATESVKAAIKNGYRSIDTAAIYKNEEGVGIGIKE 65 Query: 63 SVGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGD 122 S V REELF+TSK+WN E A K+L LQL+YLDLYL+HWP + Sbjct: 66 S-----GVAREELFITSKVWNEDQGYETTLAAFEKSLERLQLDYLDLYLIHWPGKDK--- 117 Query: 123 NPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVRPAV 182 YK+TW+ALE L G ++A+G+SNF ++++L A ++P V Sbjct: 118 -----------------YKDTWRALEKLYKDGKIRAIGVSNFQVHHLEELLKDAEIKPMV 160 Query: 183 LQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEKHG 242 QVE HP L Q EL +C +G+++ A+SPL LL+ V+ +AEKH Sbjct: 161 NQVEFHPRLTQKELRDYCKGQGIQLEAWSPLMQGQ----------LLDNEVLTQIAEKHN 210 Query: 243 RSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWRY 298 +S AQ++LRW +Q V+ IPKSI RI++N +FDF S E+M ++DALNK+ R Sbjct: 211 KSVAQVILRWDLQHGVVTIPKSIKEHRIIENADIFDFELSQEDMDKIDALNKDERV 266 >4OTK-A nrPDB Length = 318 Score = 319 bits (818), Expect = 1e-87, Method: Composition-based stats. Identities = 97/297 (32%), Positives = 142/297 (47%), Gaps = 33/297 (11%) Query: 2 TASSVLLHTGQKMPLIGLGTWKSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALK 61 A S+ L+ MP++GLG + + + A+ AL G R ID A YGNE +G A+ Sbjct: 45 AAPSITLNDEHTMPVLGLGVAELSDDETERAVSAALEIGCRLIDTAYAYGNEAAVGRAIA 104 Query: 62 ESVGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERG 121 S V REELFVT+KL + A R +L L L+Y+DLYL+HWP Sbjct: 105 AS-----GVAREELFVTTKLATPDQGFTRSQEACRASLDRLGLDYVDLYLIHWPAPPVG- 158 Query: 122 DNPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVRPA 181 Y + W + +G +++G+SNF + I++++ + V PA Sbjct: 159 -----------------KYVDAWGGMIQSRGEGHARSIGVSNFTAENIENLIDLTFVTPA 201 Query: 182 VLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEKH 241 V Q+E HP L Q+EL + +Y PL LL+ P V ++A ++ Sbjct: 202 VNQIELHPLLNQDELRKANAQHTVVTQSYCPLALGR----------LLDNPTVTSIASEY 251 Query: 242 GRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWRY 298 ++PAQ+LLRW +Q + +S P RI N VFDF + E M L LN R Sbjct: 252 VKTPAQVLLRWNLQLGNAVVVRSARPERIASNFDVFDFELAAEHMDALGGLNDGTRV 308 >4IJC-A nrPDB Length = 344 Score = 313 bits (801), Expect = 1e-85, Method: Composition-based stats. Identities = 107/314 (34%), Positives = 172/314 (54%), Gaps = 29/314 (9%) Query: 6 VLLHTGQKMPLIGLGTWKSEP--GQVKAAIKHALSAGYRHIDCASVYGNETEIGEALKES 63 L+ G ++P +GLGT + K A+K A+ AGYRHID A Y E +GEA+KE Sbjct: 25 FSLNNGVRIPALGLGTANPHEKLAETKQAVKAAIKAGYRHIDTAWAYETEPFVGEAIKEL 84 Query: 64 VGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDN 123 + G ++ RE+LF+T+K+W ++V+ +L ++L L LEY+DL L HWP FE+ + Sbjct: 85 LEDG-SIKREDLFITTKVWPVLW--DEVDRSLNESLKALGLEYVDLLLQHWPLCFEKIKD 141 Query: 124 P--------FPKNADGTVRYDST-HYKETWKALEVLV---AKGLVKALGLSNFNSRQIDD 171 P P + G Y + Y ET+K LE + V+A+G+SNF+ ++ Sbjct: 142 PKGISGLVKTPVDDSGKTMYAADGDYLETYKQLEKIYLDPNDHRVRAIGVSNFSIEYLER 201 Query: 172 VLSVASVRPAVLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEE 231 ++ V+P V QVE HP+L Q EL C + +TAYSPLGS L+ Sbjct: 202 LIKECRVKPTVNQVETHPHLPQMELRKFCFMHDILLTAYSPLGSHGAPN--------LKI 253 Query: 232 PVVLALAEKHGRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDA 291 P+V LAEK+ + +L+ + +++ I IP+S+NP RI +I+ + + +E+++L+ Sbjct: 254 PLVKKLAEKYNVTGNDLLISYHIRQGTIVIPRSLNPVRISSSIEFA--SLTKDELQELND 311 Query: 292 LNKNW--RYIVPMI 303 + + R+I Sbjct: 312 FGEKYPVRFIDEPF 325 >1A80-A nrPDB Length = 277 Score = 311 bits (797), Expect = 3e-85, Method: Composition-based stats. Identities = 92/292 (31%), Positives = 155/292 (53%), Gaps = 31/292 (10%) Query: 2 TASSVLLHTGQKMPLIGLGTWKSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALK 61 T S++L+ G +P +G G +K P + A++ AL GYRHID A++YGNE + Sbjct: 1 TVPSIVLNDGNSIPQLGYGVFKVPPADTQRAVEEALEVGYRHIDTAAIYGNEEGV----- 55 Query: 62 ESVGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERG 121 + + + R++LF+T+KLWN +H ++ A+ ++LA L L+ +DLYL+HWP Sbjct: 56 GAAIAASGIARDDLFITTKLWNDRHDGDEPAAAIAESLAKLALDQVDLYLVHWPTP---- 111 Query: 122 DNPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVRPA 181 + +Y W+ + L A GL +++G+SN ++ +++ V PA Sbjct: 112 --------------AADNYVHAWEKMIELRAAGLTRSIGVSNHLVPHLERIVAATGVVPA 157 Query: 182 VLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEKH 241 V Q+E HP Q E+ A +++ ++ PLG L V A A H Sbjct: 158 VNQIELHPAYQQREITDWAAAHDVKIESWGPLGQGKYD--------LFGAEPVTAAAAAH 209 Query: 242 GRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALN 293 G++PAQ +LRW +Q+ + PKS+ R+ +N+ VFDF + E+ +DA++ Sbjct: 210 GKTPAQAVLRWHLQKGFVVFPKSVRRERLEENLDVFDFDLTDTEIAAIDAMD 261 >3UP8-A nrPDB Length = 298 Score = 301 bits (772), Expect = 2e-82, Method: Composition-based stats. Identities = 84/295 (28%), Positives = 153/295 (51%), Gaps = 36/295 (12%) Query: 9 HTGQKMPLIGLGTWKSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALKESVGSGK 68 G +P +G GT++ +V + AL G+RH+D A +YGNE E+GEA+++S Sbjct: 29 SNGANIPALGFGTFRMSGAEVLRILPQALKLGFRHVDTAQIYGNEAEVGEAIQKS----- 83 Query: 69 AVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKN 128 +PR ++F+T+K+W + + ++ ++L L+ +++DL L+HWP Sbjct: 84 GIPRADVFLTTKVWVDNYRHDAFIASVDESLRKLRTDHVDLLLLHWPG------------ 131 Query: 129 ADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVRPAVLQVECH 188 E AL + G V+ +G+SNFN+ Q+++ ++ A QVE H Sbjct: 132 -------SDVPMAERIGALNEVRNAGKVRHIGISNFNTTQMEEAARLSDAPIATNQVEYH 184 Query: 189 PYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEKHGRSPAQI 248 PYL Q +++ G+ +T+Y + + + +P++ + +HG++ AQ+ Sbjct: 185 PYLDQTKVLQTARRLGMSLTSYYAMANGK----------VPADPLLTEIGGRHGKTAAQV 234 Query: 249 LLRWQVQRK-VICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNK-NWRYIVP 301 LRW VQ++ VI + K+ +R+ +N +FDF + EEM + L + N R + P Sbjct: 235 ALRWLVQQQDVIVLSKTATEARLKENFAIFDFALTREEMAAVRELARPNGRIVNP 289 >3WG6-A nrPDB Length = 307 Score = 269 bits (689), Expect = 1e-72, Method: Composition-based stats. Identities = 91/315 (28%), Positives = 144/315 (45%), Gaps = 43/315 (13%) Query: 1 MTASSVLLHTGQKMPLIGLGTWKSE--------PGQVKAAIKHALSAGYRHIDCASVYGN 52 + L G K+P + GT Q+ ++ AL +G+RHID A +YG Sbjct: 6 LAGKEFKLSNGNKIPAVAFGTGTKYFKRGHNDLDKQLIGTLELALRSGFRHIDGAEIYGT 65 Query: 53 ETEIGEALKESVGSGKAVPREELFVTSKLWNTKHHPE-------DVEPALRKTLADLQLE 105 EIG ALK + R+++F+T K + H + + AL+ L DL LE Sbjct: 66 NKEIGIALKN-----VGLNRKDVFITDKYNSGNHTYDGKHSKHQNPYNALKADLEDLGLE 120 Query: 106 YLDLYLMHWPYAFERGDNPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFN 165 Y+DLYL+H+PY E+ E W+ LE +GL + +G+SNF Sbjct: 121 YVDLYLIHFPYISEKSHGF--------------DLVEAWRYLERAKNEGLARNIGVSNFT 166 Query: 166 SRQIDDVLSVASVR-PAVLQVECHPYLAQNE--LIAHCHARGLEVTAYSPLGSSDRAWRH 222 + +L + P V Q+E YL ++ + +G+ + AY PLG + Sbjct: 167 IENLKSILDANTDSIPVVNQIEFSAYLQDQTPGIVEYSQQQGILIEAYGPLGPITQGRPG 226 Query: 223 PDEPVLLEEPVVLALAEKHGRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFS 282 P + VL + L+EK+ R+ QILLRW +QR ++ I + RI +++FDF Sbjct: 227 PLDKVLSK------LSEKYKRNEGQILLRWVLQRGILPITTTSKEERINDVLEIFDFELD 280 Query: 283 PEEMKQLDALNKNWR 297 E+ Q+ + K Sbjct: 281 KEDEDQITKVGKEKT 295 >4H8N-A nrPDB Length = 310 Score = 257 bits (658), Expect = 3e-69, Method: Composition-based stats. Identities = 85/308 (27%), Positives = 151/308 (49%), Gaps = 41/308 (13%) Query: 4 SSVLLHTGQKMP-LIGLGT-WKSE------PGQVKAAIKHALSAGYRHIDCASVYGNETE 55 + +G+++ +G GT WK ++ I L G+RHID A Y + E Sbjct: 12 KTFRTKSGKEISIALGTGTKWKQAQTINDVSTELVDNILLGLKLGFRHIDTAEAYNTQKE 71 Query: 56 IGEALKESVGSGKAVPREELFVTSKL---WNT-KHHPEDVEPALRKTLADLQLEYLDLYL 111 +GEALK + VPRE+++VT+K W + K + + ++ K LA L ++Y+DL+L Sbjct: 72 VGEALKRT-----DVPREDIWVTTKYSPGWGSIKAYSKSPSDSIDKALAQLGVDYVDLFL 126 Query: 112 MHWPYAFERGDNPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDD 171 +H P+ + + ++ W+AL G V+ +G+SN ++ Sbjct: 127 IHSPFFTTEQTHGY-------------TLEQAWEALVEAKKAGKVREIGISNAAIPHLEK 173 Query: 172 VLSV---ASVRPAVLQVECHPYLAQNE--LIAHCHARGLEVTAYSPLGSSDRAWRHPDEP 226 + + P V Q+E HP+L ++ C G+ V A+SPL R E Sbjct: 174 LFAASPSPEYYPVVNQIEFHPFLQNQSKNIVRFCQEHGILVEAFSPLAPLARV-----ET 228 Query: 227 VLLEEPVVLALAEKHGRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEM 286 L E + LAEK+ ++ AQ+LLR+ +QR ++ + S SR+ +++ +FDF + EE+ Sbjct: 229 NALAE-TLKRLAEKYKKTEAQVLLRYTLQRGILPVTTSSKESRLKESLNLFDFELTDEEV 287 Query: 287 KQLDALNK 294 +++ + Sbjct: 288 NEINKIGD 295 >1LQA-A nrPDB Length = 346 Score = 207 bits (527), Expect = 5e-54, Method: Composition-based stats. Identities = 79/355 (22%), Positives = 138/355 (38%), Gaps = 78/355 (21%) Query: 9 HTGQKMPLIGLGTW----KSEPGQVKAAIKHALSAGYRHIDCASVYG----------NET 54 H+ ++ +GLGT ++ A + +A++ G ID A +Y ET Sbjct: 8 HSSLEVSTLGLGTMTFGEQNSEADAHAQLDYAVAQGINLIDVAEMYPVPPRPETQGLTET 67 Query: 55 EIGEALKESVGSGKAVPREELFVTSKLWNTK------------HHPEDVEPALRKTLADL 102 +G L K RE+L + SK+ +++ AL +L L Sbjct: 68 YVGNWL------AKHGSREKLIIASKVSGPSRNNDKGIRPDQALDRKNIREALHDSLKRL 121 Query: 103 QLEYLDLYLMHWPYAFERGDNPFPKNADGTVRYDSTH------YKETWKALEVLVAKGLV 156 Q +YLDLY +HWP P N G + Y T +T AL G + Sbjct: 122 QTDYLDLYQVHWPQR--------PTNCFGKLGYSWTDSAPAVSLLDTLDALAEYQRAGKI 173 Query: 157 KALGLSNFNSRQIDDVLSVASVR--PAVLQVECHPYLAQNE-----LIAHCHARGLEVTA 209 + +G+SN + + L +A P ++ ++ +PY N L G+E+ A Sbjct: 174 RYIGVSNETAFGVMRYLHLADKHDLPRIVTIQ-NPYSLLNRSFEVGLAEVSQYEGVELLA 232 Query: 210 YSPLGSS--------------------DRAWRHPDEPVLLEEPVVLALAEKHGRSPAQIL 249 YS LG R R+ E + +A +HG PAQ+ Sbjct: 233 YSCLGFGTLTGKYLNGAKPAGARNTLFSRFTRYSGEQTQKAVAAYVDIARRHGLDPAQMA 292 Query: 250 LRWQVQRKVIC---IPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWRYIVP 301 L + V+R+ + + ++ NI+ S + + +++A+++ + Y P Sbjct: 293 LAF-VRRQPFVASTLLGATTMDQLKTNIESLHLELSEDVLAEIEAVHQVYTYPAP 346 >1PYF-A nrPDB Length = 312 Score = 202 bits (514), Expect = 1e-52, Method: Composition-based stats. Identities = 72/321 (22%), Positives = 128/321 (39%), Gaps = 73/321 (22%) Query: 17 IGLGTW---------KSEPGQVKAAIKHALSAGYRHIDCASVYG---NETEIGEALKESV 64 IGLGT K ++ A+ G +D A +YG +E IGE L+E Sbjct: 16 IGLGTNAVGGHNLYPNLNEETGKELVREAIRNGVTMLDTAYIYGIGRSEELIGEVLRE-- 73 Query: 65 GSGKAVPREELFVTSKLWNT--------KHHPEDVEPALRKTLADLQLEYLDLYLMHWPY 116 RE++ + +K + + P+ ++ ++ ++L L +Y+DL+ +H+P Sbjct: 74 -----FNREDVVIATKAAHRKQGNDFVFDNSPDFLKKSVDESLKRLNTDYIDLFYIHFP- 127 Query: 117 AFERGDNPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVA 176 D PK+ E AL + G ++++G+SNF+ Q+ + Sbjct: 128 -----DEHTPKD-------------EAVNALNEMKKAGKIRSIGVSNFSLEQLKEANKDG 169 Query: 177 SVRPAVLQVECHPYLAQNE--LIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPV- 233 V VLQ E + + E + + Y PL S A ++ ++ E + Sbjct: 170 LV--DVLQGEYNLLNREAEKTFFPYTKEHNISFIPYFPLVSGLLAGKYTEDTTFPEGDLR 227 Query: 234 --------------------VLALAEKHGRSPAQILLRWQVQRKV--ICIPKSINPSRIL 271 + +AEKH I+L W + R I IP + +++ Sbjct: 228 NEQEHFKGERFKENIRKVNKLAPIAEKHNVDIPHIVLAWYLARPEIDILIPGAKRADQLI 287 Query: 272 QNIQVFDFTFSPEEMKQLDAL 292 NI+ D T S E++ +D L Sbjct: 288 DNIKTADVTLSQEDISFIDKL 308 >3EB3-A nrPDB Length = 327 Score = 201 bits (512), Expect = 3e-52, Method: Composition-based stats. Identities = 71/343 (20%), Positives = 137/343 (39%), Gaps = 75/343 (21%) Query: 7 LLHTGQKMPLIGLGTWKSEPGQVKAAIKH-----ALSAGYRHIDCASVYGN---ETEIGE 58 L +G ++ +GLGTW + GQ+ + A G D A VY E +G Sbjct: 8 LGKSGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVLGN 67 Query: 59 ALKESVGSGKAVPREELFVTSKLWN-------TKHHPEDVEPALRKTLADLQLEYLDLYL 111 +K+ K R L +T+K++ + + L+ +L LQLEY+D+ Sbjct: 68 IIKK-----KGWRRSSLVITTKIFAGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVF 122 Query: 112 MHWPYAFERGDNPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDD 171 + P +T +ET +A+ ++ +G+ G S ++S +I + Sbjct: 123 ANRPDP-------------------NTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIME 163 Query: 172 VLSVAS----VRPAVLQVECHPYLAQN---ELIAHCHARGLEVTAYSPLG---------- 214 SVA + P Q E H + + +L H G+ +SPL Sbjct: 164 AYSVARQFNLIPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDS 223 Query: 215 -------SSDRAWRHPDEPVLLEE--------PVVLALAEKHGRSPAQILLRWQVQRKVI 259 +S + ++ + +L EE + A+AE+ G + Q+ + W ++ + + Sbjct: 224 GIPPYSRASLKGYQWLKDKILSEEGRRQQAKLKELQAIAERLGCTLPQLAIAWCLRNEGV 283 Query: 260 --CIPKSINPSRILQNIQVFDF--TFSPEEMKQLDALNKNWRY 298 + + N ++++NI S + ++D++ N Y Sbjct: 284 SSVLLGASNAEQLMENIGAIQVLPKLSSSIVHEIDSILGNKPY 326 >3N6Q-A nrPDB Length = 346 Score = 192 bits (489), Expect = 1e-49, Method: Composition-based stats. Identities = 65/334 (19%), Positives = 133/334 (39%), Gaps = 74/334 (22%) Query: 9 HTGQKMPLIGLGTWKSEP-----GQVKAAIKHALSAGYRHIDCASVYG-----NETEIGE 58 +G ++P + LG W + +A ++ A G H D A+ YG E G Sbjct: 20 KSGLRLPALSLGLWHNFGHVNALESQRAILRKAFDLGITHFDLANNYGPPPGSAEENFGR 79 Query: 59 ALKESVGSGKAVPREELFVTSK----LW----NTKHHPEDVEPALRKTLADLQLEYLDLY 110 L+E + R+EL +++K +W + + + +L ++L + LEY+D++ Sbjct: 80 LLREDFAA----YRDELIISTKAGYDMWPGPYGSGGSRKYLLASLDQSLKRMGLEYVDIF 135 Query: 111 LMHWPYAFERGDNPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQID 170 H ++T +ET AL V G +G+S+++ + Sbjct: 136 YSH-------------------RVDENTPMEETASALAHAVQSGKALYVGISSYSPERTQ 176 Query: 171 DVLSVASVRPAVLQVECHPY------LAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPD 224 ++ + L + Y + ++ L+ G+ A++PL ++ + Sbjct: 177 KMVELLREWKIPLLIHQPSYNLLNRWVDKSGLLDTLQNNGVGCIAFTPLAQGLLTGKYLN 236 Query: 225 ------------------EPVLLEEPVVLAL------AEKHGRSPAQILLRWQVQ--RKV 258 P +L E + +L A++ G+S AQ+ L W ++ R Sbjct: 237 GIPQDSRMHREGNKVRGLTPKMLTEANLNSLRLLNEMAQQRGQSMAQMALSWLLKDDRVT 296 Query: 259 ICIPKSINPSRILQNIQVF-DFTFSPEEMKQLDA 291 + + ++ +N+Q + TFS +E+ Q+D Sbjct: 297 SVLIGASRAEQLEENVQALNNLTFSTKELAQIDQ 330 >1PZ1-A nrPDB Length = 333 Score = 178 bits (452), Expect = 3e-45, Method: Composition-based stats. Identities = 65/337 (19%), Positives = 132/337 (39%), Gaps = 74/337 (21%) Query: 5 SVLLHTGQKMPLIGLGTWK--------SEPGQVKAAIKHALSAGYRHIDCASVYG---NE 53 + + TG + IGLGTW ++ I+ AL G ID A YG +E Sbjct: 4 TSIADTGIEASRIGLGTWAIGGTMWGGTDEKTSIETIRAALDQGITLIDTAPAYGFGQSE 63 Query: 54 TEIGEALKESVGSGKAVPREELFVTSKL---WNTKH-----HPEDVEPALRKTLADLQLE 105 +G+A+KE + R+++ + +K W + + + +L LQ + Sbjct: 64 EIVGKAIKEYM------KRDQVILATKTALDWKNNQLFRHANRARIVEEVENSLKRLQTD 117 Query: 106 YLDLYLMHWPYAFERGDNPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFN 165 Y+DLY +HWP +ET + ++ L G ++A+G+SNF+ Sbjct: 118 YIDLYQVHWPDPL-------------------VPIEETAEVMKELYDAGKIRAIGVSNFS 158 Query: 166 SRQIDDVLSVA---SVRPAVLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRH 222 Q+D +VA +++P E + ++ + + Y L + Sbjct: 159 IEQMDTFRAVAPLHTIQPPYNLFE---REMEESVLPYAKDNKITTLLYGSLCRGLLTGKM 215 Query: 223 PDEPVLLEEPV---------------------VLALAE-KHGRSPAQILLRWQVQRKVIC 260 +E + + + LA+ ++G+S + +RW + + Sbjct: 216 TEEYTFEGDDLRNHDPKFQKPRFKEYLSAVNQLDKLAKTRYGKSVIHLAVRWILDQPGAD 275 Query: 261 IP--KSINPSRILQNIQVFDFTFSPEEMKQLDALNKN 295 I + P ++ ++ +T + E+ K ++ + +N Sbjct: 276 IALWGARKPGQLEALSEITGWTLNSEDQKDINTILEN 312 >1GVE-A nrPDB Length = 327 Score = 146 bits (369), Expect = 1e-35, Method: Composition-based stats. Identities = 70/340 (20%), Positives = 118/340 (34%), Gaps = 80/340 (23%) Query: 15 PLIGLGTW----KSEPGQVKAAIKHALSAGYRHIDCASVYGN---ETEIGEALKESVGSG 67 P LG + + A+++ L G+ ID A VY N ET +G+ SG Sbjct: 6 PATVLGAMEMGRRMDVTSSSASVRAFLQRGHTEIDTAFVYANGQSETILGDLGLGLGRSG 65 Query: 68 KAVPREELFVTSK---LWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNP 124 V + +K ++ P DV L +L LQ +DL+ +H+P Sbjct: 66 CKVK-----IATKAAPMFGKTLKPADVRFQLETSLKRLQCPRVDLFYLHFP--------- 111 Query: 125 FPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVAS----VRP 180 T +ET +A L +G LGLSN+ S ++ ++ ++ + P Sbjct: 112 ----------DHGTPIEETLQACHQLHQEGKFVELGLSNYVSWEVAEICTLCKKNGWIMP 161 Query: 181 AVLQVECHPYLAQ--NELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEP------ 232 V Q + Q EL GL A++PL R+ + + P Sbjct: 162 TVYQGMYNAITRQVETELFPCLRHFGLRFYAFNPLAGGLLTGRYKYQDKDGKNPESRFFG 221 Query: 233 ----------------------VVLALAEKHGRSPAQI---LLRW---QVQ----RKVIC 260 V AL +G + + +RW Q + Sbjct: 222 NPFSQLYMDRYWKEEHFNGIALVEKALKTTYGPTAPSMISAAVRWMYHHSQLKGTQGDAV 281 Query: 261 IPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWRYIV 300 I + ++ QN+ + P E +DA ++ W + Sbjct: 282 ILGMSSLEQLEQNLAL--VEEGPLEPAVVDAFDQAWNLVA 319 >2CLP-A nrPDB Length = 347 Score = 140 bits (352), Expect = 1e-33, Method: Composition-based stats. Identities = 72/340 (21%), Positives = 116/340 (34%), Gaps = 80/340 (23%) Query: 15 PLIGLGTW----KSEPGQVKAAIKHALSAGYRHIDCASVY---GNETEIGEALKESVGSG 67 P LG + + A + L G+ ID A VY +ET +G GS Sbjct: 26 PATVLGAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFVYSEGQSETILGGLGLRLGGSD 85 Query: 68 KAVPREELFVTSK---LWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNP 124 V + +K L+ P+ + L +L LQ +DL+ +H P Sbjct: 86 CRVK-----IDTKAIPLFGNSLKPDSLRFQLETSLKRLQCPRVDLFYLHMP--------- 131 Query: 125 FPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVAS----VRP 180 ST +ET +A L +G LGLSN+ + ++ ++ ++ + P Sbjct: 132 ----------DHSTPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILP 181 Query: 181 AVLQVECHPYLAQ--NELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEP------ 232 V Q + Q EL GL A++PL ++ E ++P Sbjct: 182 TVYQGMYNAITRQVETELFPCLRHFGLRFYAFNPLAGGLLTGKYKYEDKDGKQPVGRFFG 241 Query: 233 ----------------------VVLALAEKHGRSPAQI---LLRW-----QVQ--RKVIC 260 V AL +G S + LRW Q+Q Sbjct: 242 NTWAEMYRNRYWKEHHFEGIALVEKALQAAYGASAPSMTSATLRWMYHHSQLQGAHGDAV 301 Query: 261 IPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWRYIV 300 I + ++ QN+ P E +DA N+ W + Sbjct: 302 ILGMSSLEQLEQNLAAA--EEGPLEPAVVDAFNQAWHLVA 339 >2C91-A nrPDB Length = 338 Score = 132 bits (333), Expect = 2e-31, Method: Composition-based stats. Identities = 69/336 (20%), Positives = 115/336 (34%), Gaps = 80/336 (23%) Query: 15 PLIGLGTW----KSEPGQVKAAIKHALSAGYRHIDCASVY---GNETEIGEALKESVGSG 67 P LGT + + A+++ L G+ +D A +Y +E +G Sbjct: 17 PATVLGTMEMGRRMDASASAASVRAFLERGHSELDTAFMYCDGQSENILGGLGLGLGSGD 76 Query: 68 KAVPREELFVTSKL--W-NTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNP 124 V + +K W P+ + L +L LQ +DL+ +H P Sbjct: 77 CTVK-----IATKANPWEGKSLKPDSIRSQLETSLKRLQCPRVDLFYLHAP--------- 122 Query: 125 FPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVAS----VRP 180 ST +ET A L +G LGLSN+ S ++ ++ ++ + P Sbjct: 123 ----------DHSTPVEETLCACHQLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILP 172 Query: 181 AVLQVECHPYLAQ--NELIAHCHARGLEVTAYSPLGSS---------------------D 217 V Q + Q EL+ GL AY+PL Sbjct: 173 TVYQGMYNATTRQVEAELLPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFG 232 Query: 218 RAWRHPDEPVLLEEPVVLALA--EK-----HGRSPAQI---LLRW-----QVQ--RKVIC 260 W +E A+A EK +G + ++ LRW Q+Q R Sbjct: 233 NNWAETYRNRFWKEHHFEAIALVEKALQTTYGTNAPRMTSAALRWMYHHSQLQGTRGDAV 292 Query: 261 IPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNW 296 I + ++ QN+ P E ++A ++ W Sbjct: 293 ILGMSSLEQLEQNLAAT--EEGPLEPAVVEAFDQAW 326 >2BP1-A nrPDB Length = 360 Score = 131 bits (329), Expect = 5e-31, Method: Composition-based stats. Identities = 72/336 (21%), Positives = 115/336 (34%), Gaps = 80/336 (23%) Query: 19 LGTW----KSEPGQVKAAIKHALSAGYRHIDCASVY---GNETEIGEALKESVGSGKAVP 71 LGT + + AA++ L G+ +D A +Y +ET +G G V Sbjct: 43 LGTMEMGRRMDAPASAAAVRAFLERGHTELDTAFMYSDGQSETILGGLGLGLGGGDCRVK 102 Query: 72 REELFVTSKL--W-NTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKN 128 + +K W P+ V L +L LQ +DL+ +H P Sbjct: 103 -----IATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAP------------- 144 Query: 129 ADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVAS----VRPAVLQ 184 T +ET A + L +G LGLSN+ S ++ ++ ++ + P V Q Sbjct: 145 ------DHGTPVEETLHACQRLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQ 198 Query: 185 VECHPYLAQ--NELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEP---------- 232 + Q EL GL AY+PL ++ E ++P Sbjct: 199 GMYNATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFGNSWA 258 Query: 233 ------------------VVLALAEKHGRSPAQI---LLRW-----QVQ--RKVICIPKS 264 V AL +G S + LRW Q+Q I Sbjct: 259 ETYRNRFWKEHHFEAIALVEKALQAAYGASAPSVTSAALRWMYHHSQLQGAHGDAVILGM 318 Query: 265 INPSRILQNIQVFDFTFSPEEMKQLDALNKNWRYIV 300 + ++ QN+ P E +DA N+ W + Sbjct: 319 SSLEQLEQNLAAT--EEGPLEPAVVDAFNQAWHLVA 352 >4R9O-A nrPDB Length = 301 Score = 118 bits (296), Expect = 3e-27, Method: Composition-based stats. Identities = 56/291 (19%), Positives = 105/291 (36%), Gaps = 48/291 (16%) Query: 22 WKSEPGQVKAAIKHALSAGYRHIDCASVYGN---ETEIGEALKESVGSGKAVPREELFVT 78 W Q+ + I+ L G +D A +YG E GEAL + RE+L + Sbjct: 30 WNMSARQLVSFIEEHLDLGVTTVDHADIYGGYQCEAAFGEALTLAPHL-----REKLQIV 84 Query: 79 SK------------LWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFP 126 +K L + + + ++L +L +YLD+ L+H P D Sbjct: 85 TKCGIATTARAENKLGHYITDRRHIILSAEQSLKNLATDYLDMLLIHRPDPLMDAD---- 140 Query: 127 KNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVRPAVLQVE 186 + +A + L G V+ G+SNF Q + S A QVE Sbjct: 141 ---------------DVAEAFQHLHQSGKVRHFGVSNFTPAQFTLLQSRLPFTLATNQVE 185 Query: 187 CHPYLA---QNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEKHG- 242 P + + + A+S LG +P+ E + +A++ Sbjct: 186 ISPVHQPLLLDGTLDQLQQLRIRPMAWSCLGGGRLFNDEAYQPLRQE---LSVIAQELNA 242 Query: 243 RSPAQILLRWQVQ--RKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDA 291 S Q++ W ++ + + I S R+ ++ + + ++ ++ Sbjct: 243 SSIEQVVYAWILRLPSQPLPIIGSGKIERVRAALEAETLSLTRQQWFRIRK 293 >1OG6-A nrPDB Length = 298 Score = 110 bits (274), Expect = 1e-24, Method: Composition-based stats. Identities = 58/291 (19%), Positives = 104/291 (35%), Gaps = 48/291 (16%) Query: 22 WKSEPGQVKAAIKHALSAGYRHIDCASVYGN---ETEIGEALKESVGSGKAVPREELFVT 78 W Q+ + I+ L G +D A +YG E GEALK + RE + + Sbjct: 27 WNMSARQLVSFIEEHLDLGVTTVDHADIYGGYQCEAAFGEALKLAPHL-----RERMEIV 81 Query: 79 SK------------LWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFP 126 SK + + + + + ++L +L ++LDL L+H P D Sbjct: 82 SKCGIATTAREENVIGHYITDRDHIIKSAEQSLINLATDHLDLLLIHRPDPLMDAD---- 137 Query: 127 KNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVRPAVLQVE 186 E A + L G V+ G+SNF Q + S A QVE Sbjct: 138 ---------------EVADAFKHLHQSGKVRHFGVSNFTPAQFALLQSRLPFTLATNQVE 182 Query: 187 CHPYLA---QNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEKHGR 243 P + + + A+S LG +P+ E + +AE+ Sbjct: 183 ISPVHQPLLLDGTLDQLQQLRVRPMAWSCLGGGRLFNDDYFQPLRDE---LAVVAEELNA 239 Query: 244 -SPAQILLRWQVQ--RKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDA 291 S Q++ W ++ + + I S R+ ++ + ++ ++ Sbjct: 240 GSIEQVVNAWVLRLPSQPLPIIGSGKIERVRAAVEAETLKMTRQQWFRIRK 290 >4EXA-A nrPDB Length = 292 Score = 74.6 bits (182), Expect = 5e-14, Method: Composition-based stats. Identities = 44/246 (17%), Positives = 76/246 (30%), Gaps = 53/246 (21%) Query: 7 LLHTGQKMPLIGLGTWK---------------SEPGQVKAAIKHALSAGYRHIDCASVYG 51 L TG + +GLGT K + + + A G ID A YG Sbjct: 35 LGDTGLAVSPLGLGTVKFGRDQGVKYPSGFTIPDDREAADLLALARDLGINLIDTAPAYG 94 Query: 52 -NETEIGEALKESVGSGKAVPREELFVTSKL--------WNTKHHPEDVEPALRKTLADL 102 +E +G L+ RE + SK+ ++ ++L L Sbjct: 95 RSEERLGPLLRG--------QREHWVIVSKVGEEFVDGQSVFDFSAAHTRRSVERSLKRL 146 Query: 103 QLEYLDLYLMHWPYAFERGDNPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLS 162 + + ++L L+H + + +++ T L L +GL+ A GLS Sbjct: 147 ETDRIELVLVH-------------SDGNDLDILENSEVYPT---LAALKREGLIGAYGLS 190 Query: 163 NFNSRQIDDVLSVASVRPAVLQVECHPYLA-QNELIAHCHARGLEVTAYSPLGSSDRAWR 221 L V + + +I + A + L S Sbjct: 191 GKTVEGGLRALREGD----CAMVTYNLNERAERPVIEYAAAHAKGILVKKALASGHACLG 246 Query: 222 HPDEPV 227 +PV Sbjct: 247 AGQDPV 252 >4EHI-A nrPDB Length = 534 Score = 30.3 bits (67), Expect = 1.2, Method: Composition-based stats. Identities = 9/18 (50%), Positives = 12/18 (66%) Query: 41 YRHIDCASVYGNETEIGE 58 ++HID VY N E+GE Sbjct: 383 FKHIDGGFVYQNSDEVGE 400 >4WO8-A nrPDB Length = 716 Score = 30.3 bits (67), Expect = 1.3, Method: Composition-based stats. Identities = 15/54 (27%), Positives = 23/54 (42%), Gaps = 2/54 (3%) Query: 194 NELIAHCHARGLEVTAYSP--LGSSDRAWRHPDEPVLLEEPVVLALAEKHGRSP 245 ++ + L + P LG++ RA H P+L P + EKHG P Sbjct: 251 SKSLKFAFNDRLGFITFCPSNLGTTLRASVHAKIPMLASLPNFKEICEKHGIQP 304 >1JPH-A nrPDB Length = 388 Score = 29.9 bits (66), Expect = 1.6, Method: Composition-based stats. Identities = 12/52 (23%), Positives = 28/52 (53%), Gaps = 4/52 (7%) Query: 16 LIGLGTWKSEPGQVKAAIKHALSA-GYRHIDCASVYGNETEIGEALKESVGS 66 ++GL W P + + + ++ G ++D ++Y +E EIG+ +K+ + Sbjct: 300 VVGL-DWTVAPKKARECVGKTVTLQG--NLDPCALYASEEEIGQLVKQMLDD 348 >4FO0-A nrPDB Length = 593 Score = 29.6 bits (65), Expect = 1.7, Method: Composition-based stats. Identities = 18/66 (27%), Positives = 24/66 (36%), Gaps = 7/66 (10%) Query: 80 KLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNADGTVRYDSTH 139 K NT HHPE + L + LD Y +HWP RG G++ Sbjct: 124 KWTNTSHHPEYLVGE-----EALYVNPLDCYNIHWPIR--RGQLNIHPGPGGSLTAVLAD 176 Query: 140 YKETWK 145 + W Sbjct: 177 IEVIWS 182 >2WUA-A nrPDB Length = 440 Score = 29.6 bits (65), Expect = 1.9, Method: Composition-based stats. Identities = 16/45 (35%), Positives = 23/45 (51%), Gaps = 1/45 (2%) Query: 205 LEVTAY-SPLGSSDRAWRHPDEPVLLEEPVVLALAEKHGRSPAQI 248 + V AY SPL + R P + PV+ AL EK +PA++ Sbjct: 36 VIVAAYRSPLCKAKRGGLKDTYPDDILAPVLKALIEKTNINPAEV 80 >5ZF1-A nrPDB Length = 301 Score = 29.2 bits (64), Expect = 2.3, Method: Composition-based stats. Identities = 8/23 (34%), Positives = 14/23 (60%) Query: 187 CHPYLAQNELIAHCHARGLEVTA 209 CH Y +++L A+C + +TA Sbjct: 197 CHRYTPKDKLEAYCRNADIIITA 219 >4YWJ-A nrPDB Length = 276 Score = 29.2 bits (64), Expect = 2.3, Method: Composition-based stats. Identities = 12/55 (21%), Positives = 20/55 (36%) Query: 128 NADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVRPAV 182 + V D TH T K +E +G + F++ + + A P V Sbjct: 75 CEEFDVLIDFTHPSVTLKNIEQCRKARRAMVIGTTGFSADEKLLLAEAAKDIPIV 129 >2BS2-A nrPDB Length = 660 Score = 29.2 bits (64), Expect = 2.5, Method: Composition-based stats. Identities = 10/52 (19%), Positives = 22/52 (42%), Gaps = 5/52 (9%) Query: 128 NADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSN---FNSRQIDDVLSVA 176 + + + D H ++ K LE L K +G+ N + ++++ V Sbjct: 475 DDNVGIFRDGPHLEKAVKELEELYK--KSKNVGIKNKRLHANPELEEAYRVP 524 >3ZL8-A nrPDB Length = 437 Score = 29.2 bits (64), Expect = 2.7, Method: Composition-based stats. Identities = 18/116 (15%), Positives = 39/116 (33%), Gaps = 11/116 (9%) Query: 169 IDDVLSVASVRPAVLQVECHPYLAQNELIAHCHAR-GLEVTAYSPLGSSDRAWRHPDEPV 227 I+ +L + AV+ E R + Y L + W + + Sbjct: 320 IEALLRFPGKKFAVVGAMKELGERSKEFHEELGERLNVLDGVYVFLSEPEAEWIKSKKII 379 Query: 228 LLEEPVVLALAEKHGRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSP 283 L + EK + L +V++ + + K+ RI + +++F+ Sbjct: 380 LKSDDP-----EKIAKD-----LATRVKKGDVVLFKASRAVRIERVLEMFEKELEK 425 >1K1Y-A nrPDB Length = 659 Score = 29.2 bits (64), Expect = 2.7, Method: Composition-based stats. Identities = 23/91 (25%), Positives = 36/91 (39%), Gaps = 24/91 (26%) Query: 75 LFVTSKLWNTKHHPEDVEPALRKTLADLQLEY--LDLYL----------MHWPYAFERGD 122 +++T ++W PE V K+L + +EY +D Y + WPY E G Sbjct: 119 VWLTERVW----QPELV-----KSLREAGIEYVVVDDYHFMSAGLSKEELFWPYYTEDGG 169 Query: 123 N---PFPKNADGTVRYDSTHYKETWKALEVL 150 FP + K+T + LE L Sbjct: 170 EVITVFPIDEKLRYLIPFRPVKKTIEYLESL 200 >5GJU-A nrPDB Length = 205 Score = 29.2 bits (64), Expect = 2.8, Method: Composition-based stats. Identities = 28/148 (18%), Positives = 48/148 (32%), Gaps = 21/148 (14%) Query: 169 IDDVLSVASVRPAVLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVL 228 ++ + + +P+ +Q EC P+L + G TA L P + Sbjct: 13 LEALNDLGYEKPSPIQAECIPHLLNGRDVLGMAQTGSGKTAAFSLPLLQNLDPELKAPQI 72 Query: 229 LEEPVVLALA----------EKHGRSPAQILL----RWQVQ-----RKVICIPKSINPSR 269 L LA KH R + L R+ VQ + + P R Sbjct: 73 LVLAPTRELAVQVAEAMTDFSKHMRGVNVVALYGGQRYDVQLRALRQGPQIVVG--TPGR 130 Query: 270 ILQNIQVFDFTFSPEEMKQLDALNKNWR 297 +L +++ S LD ++ R Sbjct: 131 LLDHLKRGTLDLSKLSGLVLDEADEMLR 158 >1XKE-A nrPDB Length = 130 Score = 29.2 bits (64), Expect = 2.8, Method: Composition-based stats. Identities = 13/58 (22%), Positives = 23/58 (39%), Gaps = 2/58 (3%) Query: 189 PYLAQNELIAHCHARGLEVT-AYSPLGSSDRAWRHPDEPVLLEEPVVLALAEKHGRSP 245 + + +++ C + T PL SDRAW + + LA K ++P Sbjct: 48 MLMRREQVLKVCANHWITTTMNLKPLSGSDRAWMWLASDFSDGDAKLEQLAAKF-KTP 104 >2W8D-A nrPDB Length = 436 Score = 28.8 bits (63), Expect = 3.0, Method: Composition-based stats. Identities = 27/165 (16%), Positives = 54/165 (32%), Gaps = 36/165 (21%) Query: 113 HWPYAFERGDNPFPKNADGTVRYDS----THYKETW--KALEVLVAKGLV-KAL------ 159 H+P+ + GD FP G D+ HY + + L GL K++ Sbjct: 199 HFPFGMDEGDTDFPAGDFGDSVVDNYFQSAHYLDQSIEQFFNDLKKDGLYDKSIIVMYGD 258 Query: 160 --GLSNFNSRQIDDVLSVASVRPAVL-QVECHPYL------AQNELIAHCHARGLEVTAY 210 G+S +++ + VL + Q++ P ++ + + T Sbjct: 259 HYGISENHNKAMAKVLGKDEITDYDNAQLQRVPLFIHAAGVKGEKVHKYAGDVDVAPTIL 318 Query: 211 SPLGSSDRAWRHPDEPVLLEE--------------PVVLALAEKH 241 LG + + +L +E P ++ K+ Sbjct: 319 HLLGVDTKDYLMSGSDILSKEHREVIPFRNGDFISPKYTKISGKY 363 >3OF5-A nrPDB Length = 228 Score = 28.8 bits (63), Expect = 3.2, Method: Composition-based stats. Identities = 17/85 (20%), Positives = 33/85 (38%), Gaps = 6/85 (7%) Query: 194 NELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEKHGRSPAQI-LLRW 252 +LI C + ++ P+ S + E V E ++ A KH + A+I L+ + Sbjct: 23 TKLIEVCEHQNIKSLCLKPVASGQSQFSELCEDV---ESILN--AYKHKFTAAEINLISF 77 Query: 253 QVQRKVICIPKSINPSRILQNIQVF 277 I ++N++ F Sbjct: 78 NQAVAPHIIAAKTKVDISIENLKQF 102 >4GL2-A nrPDB Length = 699 Score = 28.8 bits (63), Expect = 3.3, Method: Composition-based stats. Identities = 9/41 (21%), Positives = 22/41 (53%) Query: 279 FTFSPEEMKQLDALNKNWRYIVPMITVDGKRVPRDAGHPLY 319 F +++K+ L++ R+++ + + K + R A +P Y Sbjct: 338 FAVIEDDLKKPLKLDETDRFLMTLFFENNKMLKRLAENPEY 378 >4BKP-A nrPDB Length = 336 Score = 28.8 bits (63), Expect = 3.5, Method: Composition-based stats. Identities = 10/26 (38%), Positives = 19/26 (73%), Gaps = 1/26 (3%) Query: 56 IGEALKESVGSGKAVPREE-LFVTSK 80 +G+A+++ V G +P E+ +FV+SK Sbjct: 34 VGKAIQKVVADGAGLPGEDWVFVSSK 59 >5H82-A nrPDB Length = 389 Score = 28.8 bits (63), Expect = 3.6, Method: Composition-based stats. Identities = 13/43 (30%), Positives = 17/43 (39%), Gaps = 4/43 (9%) Query: 204 GLEVTAY----SPLGSSDRAWRHPDEPVLLEEPVVLALAEKHG 242 G+ V AY SPL R + + E +L A KH Sbjct: 307 GVAVEAYELPVSPLLMGRRKFVGSISGTMKETQEMLDFAAKHN 349 >3MMA-A nrPDB Length = 418 Score = 28.8 bits (63), Expect = 3.8, Method: Composition-based stats. Identities = 18/71 (25%), Positives = 25/71 (35%), Gaps = 4/71 (5%) Query: 87 HPEDVEPALRKTLA---DLQLEYLD-LYLMHWPYAFERGDNPFPKNADGTVRYDSTHYKE 142 P E A TL DL + Y D L+ WPY F+ P + + Sbjct: 178 GPALCEFACYDTLELCYDLTMTYQDELHRPMWPYKFKIKCAGCPNDCVASKARSDFAIIG 237 Query: 143 TWKALEVLVAK 153 TWK + + Sbjct: 238 TWKDDIKVDQE 248 >3Q3N-A nrPDB Length = 500 Score = 28.8 bits (63), Expect = 3.8, Method: Composition-based stats. Identities = 9/31 (29%), Positives = 15/31 (48%), Gaps = 3/31 (9%) Query: 84 TKHHPEDVEPALRKTLADLQLE---YLDLYL 111 + E + ++L DL L+ Y DL+L Sbjct: 291 KEFMYEWIIGQFERSLIDLGLDKPWYWDLFL 321 >3PNZ-A nrPDB Length = 330 Score = 28.4 bits (62), Expect = 4.6, Method: Composition-based stats. Identities = 26/136 (19%), Positives = 48/136 (35%), Gaps = 11/136 (8%) Query: 122 DNPFPKNADGTVRYDSTHYKETWKALE--VLVAKGLVKALGLSNFNSRQIDDVLSVASVR 179 D + G D+T + L+ + + ++ +G + FN + D ++ Sbjct: 51 DVQDFADLGGKTIVDATAVDYGRRVLDVAQISKETGIQIVGTAGFNKSFLWDGKIKPELK 110 Query: 180 PAVLQVECHPYLAQN----ELIAHCHA---RGLEVTAYSPLGSSDRAWRHPDEPVLLEEP 232 P + E + +N +L GLE T Y + + LEE Sbjct: 111 PIIGDFETYYEWIENTTTDKLTEFVVNEVENGLEGTPYK--AGQVKFGTGYNMITPLEEK 168 Query: 233 VVLALAEKHGRSPAQI 248 + A+A H + A I Sbjct: 169 TIRAVARAHHETKAPI 184 >4TSK-A nrPDB Length = 350 Score = 28.4 bits (62), Expect = 4.9, Method: Composition-based stats. Identities = 26/96 (27%), Positives = 37/96 (38%), Gaps = 5/96 (5%) Query: 155 LVKALGLSNFNSRQIDDVLSVASVRPAVLQVECHPYLAQNELIAHCHARGLEVTAYSPLG 214 V A+G + S I +L +PAV + E PYL + +A H + + P Sbjct: 62 RVMAVGEAVEESDVIMILLPDER-QPAVYEREIRPYLTAGKALAFAHGFNIHFSQIQPPK 120 Query: 215 SSDRAWRHPDEPVLLEEPVVLALAEKHGRSPAQILL 250 D P P L V + E G PA I + Sbjct: 121 DVDVFMVAPKGPGHL----VRRVYEAGGGVPALIAV 152 >4P22-A nrPDB Length = 446 Score = 28.0 bits (61), Expect = 5.2, Method: Composition-based stats. Identities = 10/51 (19%), Positives = 20/51 (39%), Gaps = 4/51 (7%) Query: 158 ALGLSNFNSRQIDDVLSVASVRPAVLQVECHPYLAQNELIAHCHARGLEVT 208 + ++ + ++D LS V P Q + CH RG+++ Sbjct: 148 YVPVTAYTGPLVEDFLSGFQVVVLTNT----PLEDQLRVGEFCHNRGIKLV 194 >3IVU-A nrPDB Length = 423 Score = 28.0 bits (61), Expect = 6.4, Method: Composition-based stats. Identities = 9/25 (36%), Positives = 12/25 (48%) Query: 22 WKSEPGQVKAAIKHALSAGYRHIDC 46 + ++ G A AL AG HID Sbjct: 230 FHNDTGMAIANAYCALEAGATHIDT 254 >4ZE8-A nrPDB Length = 499 Score = 27.6 bits (60), Expect = 8.4, Method: Composition-based stats. Identities = 13/63 (20%), Positives = 21/63 (33%), Gaps = 5/63 (7%) Query: 262 PKSINPSRILQNIQVFDFTFSPEEMKQ-----LDALNKNWRYIVPMITVDGKRVPRDAGH 316 P +++N +F F + E K AL N +V + +P Sbjct: 245 PDLETRGTLIENFHMFTFNMNQEVFKDKKLRRALALAVNRPIMVEALWKKQASIPAGFNF 304 Query: 317 PLY 319 P Y Sbjct: 305 PNY 307 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.311 0.143 0.429 Lambda K H 0.267 0.0436 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 14,736,307 Number of Sequences: 36641 Number of extensions: 647261 Number of successful extensions: 2262 Number of sequences better than 10.0: 81 Number of HSP's better than 10.0 without gapping: 104 Number of HSP's successfully gapped in prelim test: 39 Number of HSP's that attempted gapping in prelim test: 1810 Number of HSP's gapped (non-prelim): 144 length of query: 325 length of database: 10,336,785 effective HSP length: 97 effective length of query: 228 effective length of database: 6,782,608 effective search space: 1546434624 effective search space used: 1546434624 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.2 bits) S2: 59 (27.2 bits)