BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q9H477 (322 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 5C40-A nrPDB 663 0.0 5ZWY-A nrPDB 217 4e-57 3RY7-A nrPDB 180 1e-45 1RK2-A nrPDB 163 1e-40 4X8F-A nrPDB 157 4e-39 1VM7-A nrPDB 134 7e-32 6ILS-A nrPDB 120 1e-27 3I3Y-A nrPDB 91 5e-19 6CW5-A nrPDB 78 4e-15 3HJ6-A nrPDB 74 6e-14 1TYY-A nrPDB 71 7e-13 3GBU-A nrPDB 66 2e-11 3GO6-A nrPDB 65 5e-11 3KZH-A nrPDB 64 7e-11 5EYN-A nrPDB 64 7e-11 1V1S-A nrPDB 63 2e-10 3UBO-A nrPDB 62 4e-10 3H49-A nrPDB 59 3e-09 4LC4-A nrPDB 58 5e-09 2NWH-A nrPDB 58 5e-09 2RBC-A nrPDB 58 5e-09 4WJM-A nrPDB 54 8e-08 2QCV-A nrPDB 53 2e-07 2QHP-A nrPDB 53 2e-07 3IQ0-A nrPDB 51 5e-07 2I6B-A nrPDB 50 9e-07 3PL2-A nrPDB 48 6e-06 3LJS-A nrPDB 48 7e-06 2C4E-A nrPDB 47 7e-06 3N1C-A nrPDB 47 1e-05 4DU5-A nrPDB 46 2e-05 3LHX-A nrPDB 46 2e-05 1WYE-A nrPDB 46 2e-05 3LOO-A nrPDB 45 5e-05 2JG5-A nrPDB 44 1e-04 4N08-A nrPDB 42 4e-04 5KB6-A nrPDB 42 4e-04 2HW1-A nrPDB 40 0.001 3UQ9-A nrPDB 39 0.002 3KD6-A nrPDB 39 0.003 2VAR-A nrPDB 39 0.003 3NCA-A nrPDB 39 0.003 3B1N-A nrPDB 37 0.008 1YGJ-A nrPDB 37 0.012 2F7K-A nrPDB 36 0.029 3BF5-A nrPDB 33 0.14 2AFB-A nrPDB 33 0.23 2AWD-A nrPDB 32 0.45 1HKH-A nrPDB 30 1.8 4GM6-A nrPDB 29 2.3 2AA0-A nrPDB 29 3.5 3LUF-A nrPDB 28 4.9 3JUL-A nrPDB 28 6.6 1OXJ-A nrPDB 28 7.2 >5C40-A nrPDB Length = 330 Score = 663 bits (1710), Expect = 0.0, Method: Compositional matrix adjust. Identities = 322/322 (100%), Positives = 322/322 (100%) Query: 1 MAASGEPQRQWQEEVAAVVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCV 60 MAASGEPQRQWQEEVAAVVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCV Sbjct: 1 MAASGEPQRQWQEEVAAVVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCV 60 Query: 61 QAARLGAMTSMVCKVGKDSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNI 120 QAARLGAMTSMVCKVGKDSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNI Sbjct: 61 QAARLGAMTSMVCKVGKDSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNI 120 Query: 121 IVIVAGANLLLNTEDLRAAANVISRAKVMVCQLEITPATSLEALTMARRSGVKTLFNPAP 180 IVIVAGANLLLNTEDLRAAANVISRAKVMVCQLEITPATSLEALTMARRSGVKTLFNPAP Sbjct: 121 IVIVAGANLLLNTEDLRAAANVISRAKVMVCQLEITPATSLEALTMARRSGVKTLFNPAP 180 Query: 181 AIADLDPQFYTLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLGAEG 240 AIADLDPQFYTLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLGAEG Sbjct: 181 AIADLDPQFYTLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLGAEG 240 Query: 241 CVVLSQTEPEPKHIPTEKVKAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFIAAV 300 CVVLSQTEPEPKHIPTEKVKAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFIAAV Sbjct: 241 CVVLSQTEPEPKHIPTEKVKAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFIAAV 300 Query: 301 SVQAAGTQSSYPYKKDLPLTLF 322 SVQAAGTQSSYPYKKDLPLTLF Sbjct: 301 SVQAAGTQSSYPYKKDLPLTLF 322 >5ZWY-A nrPDB Length = 349 Score = 217 bits (553), Expect = 4e-57, Method: Compositional matrix adjust. Identities = 132/317 (41%), Positives = 180/317 (56%), Gaps = 15/317 (4%) Query: 13 EEVAAVVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCVQAARLGAMTSMV 72 E ++VVGSC D V +P+ GET+H F GFGGKGANQ V A RLGA +MV Sbjct: 33 EYAPDILVVGSCFLDYVGYVDHMPQVGETMHSVSFHKGFGGKGANQAVAAGRLGAKVAMV 92 Query: 73 CKVGKDSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNE-GQNIIVIVAGANLLL 131 VG D G+DYI+ L++N + T + ++T ++TG A I+V+ + N IVI A Sbjct: 93 SMVGTDGDGSDYIKELERNGVDTAYMFRTGKSSTGLAMILVDTKSSNNEIVICPNATNHF 152 Query: 132 NTEDLRAAANVISRA-----KVMVCQLEITPATSLEALTMARRSGVKTLFNPAPA----- 181 E LRA N R K ++CQ EI T+L+ + A GV T+FN APA Sbjct: 153 TPELLRAQTNNYERILHTGLKYLICQNEIPLPTTLDTIKEAHSRGVYTVFNSAPAPKPAE 212 Query: 182 IADLDPQFYTLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLGAEGC 241 + + P F +FC NE EA ++TG+ V A A L + G + V+ITLGA G Sbjct: 213 VEQIKP-FLPYVSLFCPNEVEATLITGVKVTDTESAFSAIKALQQLGVRDVVITLGAAG- 270 Query: 242 VVLSQTEPEPKHIPTEKVKAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFIAAVS 301 VLS+ EP H+ + VKAVDTTGAGD FVG++ ++++ NL + R+N AA+S Sbjct: 271 FVLSENGAEPVHVTGKHVKAVDTTGAGDCFVGSMVYFMSRGRNLL--EACKRANECAAIS 328 Query: 302 VQAAGTQSSYPYKKDLP 318 V GTQ SYP+ +LP Sbjct: 329 VTRKGTQLSYPHPSELP 345 >3RY7-A nrPDB Length = 304 Score = 180 bits (456), Expect = 1e-45, Method: Compositional matrix adjust. Identities = 110/296 (37%), Positives = 164/296 (55%), Gaps = 5/296 (1%) Query: 18 VVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGG-KGANQCVQAARLGAMTSMVCKVG 76 VV++GS D R + GET+H + FGG KGANQ + AR+ A T+ + K+G Sbjct: 5 VVILGSTNVDQFLTVERYAQPGETLHVEEAQKAFGGGKGANQAIATARMQADTTFITKIG 64 Query: 77 KDSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNIIVIVAGANLLLNTEDL 136 D + +E+ K I T + +T +A TG A I VN EGQN I + GAN+ + ED+ Sbjct: 65 TDGVADFILEDFKVAHIDTSYIIKTAEAKTGQAFITVNAEGQNTIYVYGGANMTMTPEDV 124 Query: 137 RAAANVISRAKVMVCQLEITPATSLEALTMARRSGVKTLFNPAPAIADLDPQFYTLSDVF 196 A + I A +V QLE+ + A +A+ GV T+ NPAPA A L + +L D+ Sbjct: 125 INAKDAIINADFVVAQLEVPIPAIISAFEIAKAHGVTTVLNPAPAKA-LPNELLSLIDII 183 Query: 197 CCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLGAEGCVVLSQTEPEPKHIPT 256 NE+EAE+L+G+ V + + A L G + V+ITLG +G T+ + +HI Sbjct: 184 VPNETEAELLSGIKVTNEQSMKDNANYFLSIGIKTVLITLGKQGTYF--ATKNQSQHIEA 241 Query: 257 EKVKAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFIAAVSVQAAGTQSSYP 312 KV A+DTT AGD+F+GA L + +L D ++ N ++++VQ G Q+S P Sbjct: 242 YKVNAIDTTAAGDTFIGAFVSRLNKSQD-NLADAIDFGNKASSLTVQKHGAQASIP 296 >1RK2-A nrPDB Length = 309 Score = 163 bits (412), Expect = 1e-40, Method: Compositional matrix adjust. Identities = 108/305 (35%), Positives = 164/305 (53%), Gaps = 5/305 (1%) Query: 13 EEVAAVVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCVQAARLGAMTSMV 72 + ++VV+GS D + P GET+ G+ + + FGGKGANQ V A R GA + + Sbjct: 2 QNAGSLVVLGSINADHILNLQSFPTPGETVTGNHYQVAFGGKGANQAVAAGRSGANIAFI 61 Query: 73 CKVGKDSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNIIVIVAGANLLLN 132 G DS G + L ++I K +TG A I VN EG+N+I I AGAN L+ Sbjct: 62 ACTGDDSIGESVRQQLATDNIDITPVSVIKGESTGVALIFVNGEGENVIGIHAGANAALS 121 Query: 133 TEDLRAAANVISRAKVMVCQLEITPATSLEALTMARRSGVKTLFNPAPAIADLDPQFYTL 192 + A I+ A ++ QLE + + A +A ++ NPAPA +L + L Sbjct: 122 PALVEAQRERIANASALLMQLESPLESVMAAAKIAHQNKTIVALNPAPA-RELPDELLAL 180 Query: 193 SDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLGAEGCVVLSQTEPEPK 252 D+ NE+EAE LTG+ V + DA +AA VL ++G + V+ITLG+ G V + E + Sbjct: 181 VDIITPNETEAEKLTGIRVENDEDAAKAAQVLHEKGIRTVLITLGSRG--VWASVNGEGQ 238 Query: 253 HIPTEKVKAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFIAAVSVQAAGTQSSYP 312 +P +V+AVDT AGD+F GAL A L + + ++ AA++V G Q S P Sbjct: 239 RVPGFRVQAVDTIAAGDTFNGAL--ITALLEEKPLPEAIRFAHAAAAIAVTRKGAQPSVP 296 Query: 313 YKKDL 317 +++++ Sbjct: 297 WREEI 301 >4X8F-A nrPDB Length = 309 Score = 157 bits (398), Expect = 4e-39, Method: Compositional matrix adjust. Identities = 114/300 (38%), Positives = 162/300 (54%), Gaps = 5/300 (1%) Query: 18 VVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCVQAARLGAMTSMVCKVGK 77 +VV+GS D V P+ GET+HG + + GGKGANQ V AAR+ A + VG Sbjct: 7 LVVLGSVNADHVLQVPSFPRPGETLHGRNYQVIPGGKGANQAVAAARMQADVGFIACVGD 66 Query: 78 DSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNIIVIVAGANLLLNTEDLR 137 DSFG + E+ K + I+T + TG A I V++ G+N I I A AN L + Sbjct: 67 DSFGINIRESFKLDGINTAGVKLQPNCPTGIAMIQVSDSGENSICISAEANAKLTAAAIE 126 Query: 138 AAANVISRAKVMVCQLEITPATSLEALTMARRSGVKTLFNPAPAIADLDPQFYTLSDVFC 197 I A+ ++ QLE L+A A+ + + NPAPA +L + D+ Sbjct: 127 PDLAAIRDARYLLMQLETPLDGILKAAQEAKTAKTNVILNPAPA-RELPDELLKCVDLIT 185 Query: 198 CNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLGAEGCVVLSQTEPEPKHIPTE 257 NE+EAE+LTG+TV + A +AA L +G ++VIITLG++G V LSQ + IP Sbjct: 186 PNETEAEVLTGITVYDDSSAQQAADALHCKGIEIVIITLGSKG-VWLSQNG-RGQRIPGF 243 Query: 258 KVKAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFIAAVSVQAAGTQSSYPYKKDL 317 VKA DTT AGD+F GAL L + LE + ++ AA+SV G Q+S P + ++ Sbjct: 244 VVKATDTTAAGDTFNGALVTGL--LQEMPLESAIKFAHAAAAISVTRFGAQTSIPTRAEV 301 >1VM7-A nrPDB Length = 311 Score = 134 bits (336), Expect = 7e-32, Method: Compositional matrix adjust. Identities = 106/301 (35%), Positives = 153/301 (50%), Gaps = 14/301 (4%) Query: 18 VVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCVQAARLGAM-TSMVCKVG 76 + VVGS D+V K GET + + GGKGANQ V A++G V +G Sbjct: 17 ISVVGSSNIDIVLKVDHFTKPGETQKAIEMNVFPGGKGANQAVTVAKIGEKGCRFVTCIG 76 Query: 77 KDSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNIIVIVAGANLLLNTEDL 136 D + + IEN ++ I+ Y TG A I V+ GQN I+I GAN L E + Sbjct: 77 NDDYSDLLIENYEKLGITG---YIRVSLPTGRAFIEVDKTGQNRIIIFPGANAELKKELI 133 Query: 137 RAAANVISRAKVMVCQLEITPATSLEALTMARRSGVKTLFNPAPAIADLDPQFYTLSDVF 196 N +S + +++ Q EI T+LE A+R +F+PAPA ++ + + D Sbjct: 134 DW--NTLSESDILLLQNEIPFETTLEC---AKRFNGIVIFDPAPA-QGINEEIFQYLDYL 187 Query: 197 CCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLGAEGCVVLSQTEPEPKHIPT 256 NE E E L+ G +AA L+ G + VI+ LG +G +++++ E KH PT Sbjct: 188 TPNEKEIEALSKDFFGEFLTVEKAAEKFLELGVKNVIVKLGDKGVLLVNKNEK--KHFPT 245 Query: 257 EKVKAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFIAAVSVQAAGTQSSYPYKKD 316 KVKAVDTT AGD F GA A L+ N E+ + AA+SV G QSS P +++ Sbjct: 246 FKVKAVDTTAAGDVFNGAFAVALSEGKN--PEEAVIFGTAAAAISVTRLGAQSSIPAREE 303 Query: 317 L 317 + Sbjct: 304 V 304 >6ILS-A nrPDB Length = 313 Score = 120 bits (300), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 89/307 (28%), Positives = 146/307 (47%), Gaps = 13/307 (4%) Query: 18 VVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCVQAARLGAMTSMVCKVGK 77 +VVVGS D+ RLPK GETI GGKGANQ A+L T V ++G+ Sbjct: 5 LVVVGSANADIYVEIERLPKEGETISAKTGQTLAGGKGANQAACGAKLMYPTYFVGRLGE 64 Query: 78 DSFGNDYIENLKQNDISTEFTY--QTKDAATGTASIIVNNEGQNIIVIVAGANL-----L 130 D+ G E L + Y + TG A +++ ++GQN I+IV GAN+ + Sbjct: 65 DAHGKLIAEALGDDGCGVHLDYVRSVNNEPTGHAVVMLQSDGQNSIIIVGGANMKAWPEI 124 Query: 131 LNTEDLRAAANVISRAKVMVCQLEITPATSLEALTMARRSGVKTLFNPAPAIADLDPQFY 190 ++ +DL ++ A +++ Q EI + +++ +++GV + + + + Sbjct: 125 MSDDDLE----IVRNAGIVLLQREIPDSINIQVAKAVKKAGVPVILDVGGMDTPIPNELL 180 Query: 191 TLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLGAEGCVVLSQTEPE 250 D+ NE+E LTG+ + +A K G + V++ LG++G + Q E Sbjct: 181 DSIDILSPNETELSRLTGMPTETFEQISQAVAKCHKLGVKQVLVKLGSKGSALFIQGEKP 240 Query: 251 PKHIPTEKVKAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFIAAVSVQAAGTQSS 310 + + VDTTGAGD+F AF +A S E+ L + A++ VQ G S Sbjct: 241 IQQSIIPAAQVVDTTGAGDTFTA--AFAVAMVEGKSHEECLRFAAAAASLCVQVKGAIPS 298 Query: 311 YPYKKDL 317 P +K + Sbjct: 299 MPDRKSV 305 >3I3Y-A nrPDB Length = 299 Score = 91.3 bits (225), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 84/307 (27%), Positives = 138/307 (44%), Gaps = 36/307 (11%) Query: 18 VVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCVQAARLGAMTSMVCKVGK 77 V V G+ D +PK G +IHG K GGKGANQ + +R G T ++ G Sbjct: 5 VYVTGNITVDETWSIPDIPKKGASIHGVKVSQDIGGKGANQAIILSRCGIETRLIAATGN 64 Query: 78 DSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQN-IIVIVAGANLLLNTEDL 136 DS G +I +N+ + + T+ I+ + +G N II A A+ E + Sbjct: 65 DSNGA-WIRQQIKNEPLMLLPDGHFNQHSDTSIILNSADGDNAIITTTAAADTFSLDEMI 123 Query: 137 RAAANVISRAKVMVCQLEITPATSLEALTMARRSGVKTLFNPAPAIADLDPQF---YTLS 193 A+ ++ +++ Q + + AR G+ T+FNP+P ++P F + L Sbjct: 124 PHMADAVA-GDILLQQGNFSLDKTRALFQYARSRGMTTVFNPSP----VNPDFCHLWPLI 178 Query: 194 DVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLGAEGCVVLSQTEPEPKH 253 D+ NESEAE+L G + ++IT GA G ++ E + + Sbjct: 179 DIAVVNESEAELLQ------------------PYGVKTLVITQGAAGAWLVQ--EGQRQF 218 Query: 254 IPTEKVKAVDTTGAGDSFVGAL---AFYLAYYPNLSLEDMLNRSNFIAAVSVQAAGTQSS 310 P +A+DTTGAGD+F+ + A P+ +R+ I +V GT S+ Sbjct: 219 CPAVPAEALDTTGAGDTFLAVMLASALLRGVAPDALALAHASRAAAI---TVSRRGTLSA 275 Query: 311 YPYKKDL 317 +P ++L Sbjct: 276 FPGSREL 282 >6CW5-A nrPDB Length = 332 Score = 78.2 bits (191), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 91/316 (28%), Positives = 133/316 (42%), Gaps = 31/316 (9%) Query: 19 VVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCVQAARLGAMTSMVCKVGKD 78 +V GS D + + GETI GGKGANQ AR G + +G D Sbjct: 16 LVRGSVNIDEFFHLPHIVRPGETISSTGLTKRAGGKGANQAFAVARAGGQVELDGAIGDD 75 Query: 79 SFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNIIVIVAGANLLLNTEDLRA 138 G E L+ + T+ KD TG A I +G+N IV+ AGAN L + Sbjct: 76 --GIWVKEMLESAGVGTDKLKIVKDEVTGRAVIQSAADGENSIVLHAGANYYLPSPTPTT 133 Query: 139 AANVISRAKVMVCQLEITPATSLEALTMARRSG--VKTLFNPAPAI--ADLDPQFYTLSD 194 + + ++ Q E+ +++L LT A +S + ++FNP+P + A L + Sbjct: 134 SLATYTH---LLVQNEVPLSSTLAYLTAAGQSSPPLTSVFNPSPMLTPAQLREFPWKHLS 190 Query: 195 VFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQV----------------VIITLGA 238 NE E L L GS+A+ GEA L+ +I TLGA Sbjct: 191 WLIVNEGELGDLL-LAFGSSANPGEAKEDELQAKASAGILELHENDYFSKNVGIICTLGA 249 Query: 239 EGCVVLSQTEPEPKHIPTEKVK--AVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNF 296 +G ++ + E ++P K++ DTTGAGD F G F SL+D L Sbjct: 250 KG-ILCYEPGKEVGYLPAAKLQNPVKDTTGAGDCFAG--YFVAGLMSGKSLQDALKTCLV 306 Query: 297 IAAVSVQAAGTQSSYP 312 + V+ G S P Sbjct: 307 ACGICVENEGAMESVP 322 >3HJ6-A nrPDB Length = 327 Score = 74.3 bits (181), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 82/315 (26%), Positives = 137/315 (43%), Gaps = 32/315 (10%) Query: 18 VVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCVQAARLGAMTSMVCKVGK 77 VV +G + D++S + ++ FGG AN V +RLG +++ ++G Sbjct: 24 VVSLGEILVDMISTE----EVNSLSQSREYTRHFGGSPANIAVNLSRLGKKVALISRLGA 79 Query: 78 DSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNIIVIVAGANLLLNTEDLR 137 D+FGN ++ LK I T+ Q K+ T + + + + A++ L +D+ Sbjct: 80 DAFGNYLLDVLKGEQIITDGIQQDKERRTTIVYVSKSTRTPDWLPYRE-ADMYLQEDDI- 137 Query: 138 AAANVISRAKVMVCQ---LEITPA--TSLEALTMARRSGVKTLFNP------APAIAD-- 184 +I R+KV L PA T+++A AR G F+P P D Sbjct: 138 -IFELIKRSKVFHLSTFILSRKPARDTAIKAFNYAREQGKIVCFDPCYRKVLWPEGDDGA 196 Query: 185 -LDPQFYTLSDVFCCNESEAEILTGLTVGSAADAGEAAL-VLLKRGCQVVIITLGAEGCV 242 + + + +D + +A L G D+ E + L+ G + VI+TLG EG Sbjct: 197 GVVEEIISRADFVKPSLDDARHLFG------PDSPENYVKRYLELGVKAVILTLGEEG-- 248 Query: 243 VLSQTEPEPKHIPTEKVKAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFIAAVSV 302 V++ E IP AVD TGAGD+F F +++ + N +AA + Sbjct: 249 VIASDGEEIIRIPAFSEDAVDVTGAGDAFWS--GFICGLLDGYTVKRSIKLGNGVAAFKI 306 Query: 303 QAAGTQSSYPYKKDL 317 + G S P K+D+ Sbjct: 307 RGVGALSPVPSKEDI 321 >1TYY-A nrPDB Length = 339 Score = 70.9 bits (172), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 78/282 (27%), Positives = 119/282 (42%), Gaps = 24/282 (8%) Query: 52 GGKGANQCVQAARLGAMTSMVCKVGKDSFGNDYIENLKQNDISTEFTYQTKDAATGTASI 111 GG AN V ARLG + +G D G ++ + Q D + T+ DA +A + Sbjct: 50 GGASANVGVCVARLGGECGFIGCLGDDDAGR-FLRQVFQ-DNGVDVTFLRLDADLTSAVL 107 Query: 112 IVN----NEGQNIIVIVAGANLLLNTEDLRAAANVISRAKVMVCQLEITPATS--LEALT 165 IVN E ++ GA+ ++ +DL L PA LE Sbjct: 108 IVNLTADGERSFTYLVHPGADTYVSPQDL-PPFRQYEWFYFSSIGLTDRPAREACLEGAR 166 Query: 166 MARRSGVKTLFN-----PAPAIADLDPQFYTLSDVFC--CNESEAEILTGLTVGSAADAG 218 R +G LF+ D P+ S C S E+ + A+ Sbjct: 167 RMREAGGYVLFDVNLRSKMWGNTDEIPELIARSAALASICKVSADELCQ---LSGASHWQ 223 Query: 219 EAALVLLKRGCQVVIITLGAEGCVVLSQTEPEPKHIPTEKVKAVDTTGAGDSFVGALAFY 278 +A L GC II+LGA+G +++ T H P +V VDTTGAGD+FVG L F Sbjct: 224 DARYYLRDLGCDTTIISLGADGALLI--TAEGEFHFPAPRVDVVDTTGAGDAFVGGLLFT 281 Query: 279 LAY---YPNLSLEDMLNRSNFIAAVSVQAAGTQSSYPYKKDL 317 L+ + + L + ++ +N A++V A G ++ P+ L Sbjct: 282 LSRANCWDHALLAEAISNANACGAMAVTAKGAMTALPFPDQL 323 >3GBU-A nrPDB Length = 313 Score = 65.9 bits (159), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 75/310 (24%), Positives = 135/310 (43%), Gaps = 35/310 (11%) Query: 21 VGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCVQAARLGAMTSMVCKVGKDSF 80 +G + DL+S+ K H GG AN V +RLG +S++ KVG D F Sbjct: 7 IGELLIDLISVEEGDLKDVRLFEKHP-----GGAPANVAVGVSRLGVKSSLISKVGNDPF 61 Query: 81 GNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNIIVI--VAGANLLLNTEDLRA 138 G IE L + ++ T + + TG + + + ++ VA N+ LN + Sbjct: 62 GEYLIEELSKENVDTRGIVKDEKKHTGIVFVQLKGASPSFLLYDDVAYFNMTLNDINW-- 119 Query: 139 AANVISRAKVMVCQLEITPATSLEALTMARRSGVKTLFNPAPAIADLDPQFYTLS---DV 195 +++ AK++ + ++ +AR +T+ I + ++ D+ Sbjct: 120 --DIVEEAKIV----------NFGSVILARNPSRETVMKVIKKIKGSSLIAFDVNLRLDL 167 Query: 196 FCCNESEA-EIL-TGLTVGSAADAGEAALVLLK------RGCQVVIITLGAEGCVVLSQT 247 + E E ++L + + A E ++ L+ +G + ITLG +G ++ Sbjct: 168 WRGQEEEMIKVLEESIKLADIVKASEEEVLYLENQGVEVKGSMLTAITLGPKGFRLIKNE 227 Query: 248 EPEPKHIPTEKVKAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFIAAVSVQAAGT 307 +P+ V +DTTGAGD+F+ AL + L L + +N +AA+S Q G Sbjct: 228 --TVVDVPSYNVNPLDTTGAGDAFMAALLVGILKLKGLDLLKLGKFANLVAALSTQKRGA 285 Query: 308 QSSYPYKKDL 317 S+ P K +L Sbjct: 286 WST-PRKDEL 294 >3GO6-A nrPDB Length = 310 Score = 64.7 bits (156), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 83/275 (30%), Positives = 115/275 (41%), Gaps = 29/275 (10%) Query: 18 VVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCVQAARLGAMTSMVCKVGK 77 V VVGS DL + LP+ GET+ GGKGANQ V AAR GA G Sbjct: 22 VCVVGSVNMDLTFVVDALPRPGETVLAASLTRTPGGKGANQAVAAARAGAQVQFSGAFGD 81 Query: 78 DSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNIIVIVAGANLLLNTEDLR 137 D +L+ N + + T T +GTA I+V+ +N +++ GAN L Sbjct: 82 DPAAAQLRAHLRANAVGLDRTV-TVPGPSGTAIIVVDASAENTVLVAPGAN-----AHLT 135 Query: 138 AAANVISRAKVMVCQLEITPATSLEALTMARRSGVKTLFNPAPAIADLDP--QFYTLSDV 195 + ++ V++ QLEI AT+L A A+ + + N +PA D ++DV Sbjct: 136 PVPSAVANCDVLLTQLEIPVATALAAARAAQSADAVVMVNASPAGQDRSSLQDLAAIADV 195 Query: 196 FCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLGAEGCVVLSQTEPEPKHIP 255 NE EA + + L RG + V GA+G +P Sbjct: 196 VIANEHEANDWP-------SPPTHFVITLGVRGARYV----GADGVF----------EVP 234 Query: 256 TEKVKAVDTTGAGDSFVGALAFYLAYYPNLSLEDM 290 V VDT GAGD F G LA P E + Sbjct: 235 APTVTPVDTAGAGDVFAGVLAANWPRNPGSPAERL 269 >3KZH-A nrPDB Length = 328 Score = 64.3 bits (155), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 67/296 (22%), Positives = 126/296 (42%), Gaps = 17/296 (5%) Query: 18 VVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCVQAARLGAMTSMVCKVGK 77 ++V G+ + D+ + + + GH I FGG N AR+G T+ + +G Sbjct: 9 LLVFGASVVDVFGFSKASYRPYNSTPGH-VKISFGGVCRNIAENMARVGVNTNFMSILGN 67 Query: 78 DSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNIIVIVAGANL-LLNTEDL 136 D G +E+ K+ + + + +T T I++ G+ + I ++ +NT+ + Sbjct: 68 DEHGKSIVEHSKKIGYHMDDSMVIEGGSTPTYLAILDENGEMVSAIADMKSIGAMNTDFI 127 Query: 137 RAAANVISRAKVMVCQLEITPATSLEALTMARRSGVKTLFNPAPA-----IADLDPQFYT 191 + + A+ V L+ +E L + + +P A + L F+T Sbjct: 128 DSKREIFENAEYTV--LDSDNPEIMEYLLKNFKDKTNFILDPVSAEKASWVKHLIKDFHT 185 Query: 192 LSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLGAEGCVVLSQTEPEP 251 + N EAEIL G + D +A+ L G + V I+L A+G + Sbjct: 186 IK----PNRHEAEILAGFPITDTDDLIKASNYFLGLGIKKVFISLDADG--IFYNDGVSC 239 Query: 252 KHIPTEKVKAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFIAAVSVQAAGT 307 I +V + TGAGDSFV L + Y + +ED++ + ++ +++ T Sbjct: 240 GKIKATEVDVKNVTGAGDSFVAGLGY--GYMNKMPIEDIVKFAMTMSNITISHEET 293 >5EYN-A nrPDB Length = 323 Score = 64.3 bits (155), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 67/291 (23%), Positives = 127/291 (43%), Gaps = 41/291 (14%) Query: 52 GGKGANQCVQAARLGAMTSMVCKVGKDSFGNDYIENLKQNDISTEFTYQTKDAATGTASI 111 GG AN V ARL ++ +VG D FG + L + + + T T + Sbjct: 44 GGAPANVAVAIARLSGRSAFFGRVGNDPFGRFMQQTLTDEQVDCQHLHFDPVHRTSTVVV 103 Query: 112 IVNNEGQN--IIVIVAGANLLLNTEDLRAAANVISRAKVMVCQLEI----TPATSLEALT 165 ++ G+ ++ A+ L D+ + + VC + + + +++ A+ Sbjct: 104 DLDEHGERSFTFMVKPSADQFLQLSDI---PSFQKGEWLHVCSIALANQPSRSSTFAAIA 160 Query: 166 MARRSGVKTLFNPAPAIADLDPQFYT--------------LSDVFCCNESEAEILTGLTV 211 + G F+P +L + ++ L+DV +E E + LTG Sbjct: 161 QMKEVGGYVSFDP-----NLREEVWSEPQELQATVMRAVGLADVVKFSEEELQFLTGT-- 213 Query: 212 GSAADAGEAALVLLKRGCQVVIITLGAEGCVVLSQTEPEPKHIPTEK-VKAVDTTGAGDS 270 + + G A+ + +V++TLGA+G +V + P + I + K VK +DTTGAGD+ Sbjct: 214 -QSIEEGLQAIADFQ--IPLVVVTLGAKGALVAT---PNSQQIVSGKAVKPIDTTGAGDA 267 Query: 271 FVGALAFYLA----YYPNLSLEDMLNRSNFIAAVSVQAAGTQSSYPYKKDL 317 FVG L + L+ ++ ++ D + +N A++ G ++ P + L Sbjct: 268 FVGGLLYRLSVAQDWHNQATILDAVKWANGCGALATTQKGAMTALPNQAAL 318 >1V1S-A nrPDB Length = 309 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 87/324 (26%), Positives = 126/324 (38%), Gaps = 46/324 (14%) Query: 18 VVVVGSCMTDLVSLTSRLPKTGETIHGHKFF-IGFGGKGANQCVQAARLGAMTSMVCKVG 76 VV G + LV P+ + G + + GG N V ARLG V +VG Sbjct: 4 VVTAGEPLVALV------PQEPGHLRGKRLLEVYVGGAEVNVAVALARLGVKVGFVGRVG 57 Query: 77 KDSFGNDYIENLKQNDIS-TEFT--------YQTKDAATGTASIIVNNEGQNIIVIVAGA 127 +D G E L+ + T F Y + G + +G + GA Sbjct: 58 EDELGAMVEERLRAEGVDLTHFRRAPGFTGLYLREYLPLGQGRVFYYRKGSAGSALAPGA 117 Query: 128 NLLLNTEDLRAAANVISRAKVMVCQLEITPATSLEALTMARRSGVK---------TLFNP 178 D + + + A SL A+ A+R GV+ TL++P Sbjct: 118 F----DPDYLEGVRFLHLSGITPALSPEARAFSLWAMEEAKRRGVRVSLDVNYRQTLWSP 173 Query: 179 APAIADLDPQFYTLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLGA 238 A L+ + D+ +E EAE+L G V A A A V+LKRG + GA Sbjct: 174 EEARGFLERALPGV-DLLFLSEEEAELLFG-RVEEALRALSAPEVVLKRGAK------GA 225 Query: 239 EGCVVLSQTEPEPKHIPTEKVKAVDTTGAGDSFVGALAFYLA-YYPNLSLEDMLNRSNFI 297 V + E V+AVD GAGD+F A YLA L +E+ L +N + Sbjct: 226 WAFVDGRRVEGS-----AFAVEAVDPVGAGDAFA---AGYLAGAVWGLPVEERLRLANLL 277 Query: 298 AAVSVQAAGTQSSYPYKKDLPLTL 321 A + G PY++DL + L Sbjct: 278 GASVAASRGDHEGAPYREDLEVLL 301 >3UBO-A nrPDB Length = 354 Score = 61.6 bits (148), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 73/277 (26%), Positives = 113/277 (40%), Gaps = 39/277 (14%) Query: 52 GGKGANQCVQAARLGAMTSMVCKVGKDSFGNDYIENLKQNDISTEFTYQTK----DAATG 107 GG N A LG + KV D G + +++ + +QTK T Sbjct: 60 GGSAGNTAAGVASLGGRAAYFGKVADDQLGEIFTHDIRAQGVH----FQTKPLDGHPPTA 115 Query: 108 TASIIVNNEGQNIIVIVAGANLLLNTEDLRAAANVISRAKVMVCQLEI-TPATSLEALTM 166 + I V +G+ + GA + L ED+ +V++++KV + + P + +A+ Sbjct: 116 RSMIFVTEDGERSMNTYLGACVELGPEDVED--DVVAQSKVTYFEGYLWDPPRAKDAIRE 173 Query: 167 ARRSGVKTLFNPAPAIADLDPQFYTLSDVFCCNESEAEILTGLTVGSA----ADAGEA-- 220 A R A A TLSD FC + +E L + G+ A+ EA Sbjct: 174 AARI----------AHAHGRETAMTLSDSFCVHRYRSEFLELMRSGTVDIVFANRQEALA 223 Query: 221 ---------ALVLLKRGCQVVIITLGAEGCVVLSQTEPEPKHIPTEKVKAVDTTGAGDSF 271 AL LL R C++ +TL EG VV+ E + + + VDTTGAGD + Sbjct: 224 LYETEDFDRALELLARDCKLAAVTLSEEGSVVVRGAE-RVRVGASVLEQVVDTTGAGDLY 282 Query: 272 VGALAFYLAYYPNLSLEDMLNRSNFIAAVSVQAAGTQ 308 A F Y SLE+ N A + + G + Sbjct: 283 --AAGFLFGYTSGRSLEECSKLGNLAAGIVIGQIGPR 317 >3H49-A nrPDB Length = 325 Score = 58.9 bits (141), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 72/275 (26%), Positives = 125/275 (45%), Gaps = 22/275 (8%) Query: 52 GGKGANQCVQAARLGAMTSMVCKVGKDSFGNDYIENLKQNDISTEFTYQTKDAATGTASI 111 GG N+ +RLG T+++ ++GKD+ G +++ ++ +I + Q T Sbjct: 43 GGDAINEATIISRLGHRTALMSRIGKDAAGQFILDHCRKENIDIQSLKQDVSIDTSINVG 102 Query: 112 IVNNEGQNIIVIVAGANLL-LNTEDLRAAANVISRAKVM-VCQLEITPATSLEALT-MAR 168 +V +G+ V +L LN +D+ A S+AK++ + + +P +ALT + Sbjct: 103 LVTEDGERTFVTNRNGSLWKLNIDDVDFAR--FSQAKLLSLASIFNSPLLDGKALTEIFT 160 Query: 169 RSGVKTLFNPAPAIA-----DLDPQFYTLS--DVFCCNESEAEILTGL-TVGSAADAGEA 220 ++ + + A I LD LS D N +EA++LTG T+ AD Sbjct: 161 QAKARQMIICADMIKPRLNETLDDICEALSYVDYLFPNFAEAKLLTGKETLDEIADC--- 217 Query: 221 ALVLLKRGCQVVIITLGAEGCVVLSQTEPEPKHIPTEKVKAVDTTGAGDSFVGALAFYLA 280 L G + V+I G +GC + + + K + A+DT GAGD+F A F A Sbjct: 218 ---FLACGVKTVVIKTGKDGCFI-KRGDMTMKVPAVAGITAIDTIGAGDNF--ASGFIAA 271 Query: 281 YYPNLSLEDMLNRSNFIAAVSVQAAGTQSSYPYKK 315 +L + +N AA+SV + G + +K Sbjct: 272 LLEGKNLRECARFANATAAISVLSVGATTGVKNRK 306 >4LC4-A nrPDB Length = 352 Score = 58.2 bits (139), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 70/282 (24%), Positives = 109/282 (38%), Gaps = 49/282 (17%) Query: 52 GGKGANQCVQAARLGAMTSMVCKVGKDSFGNDYIENLKQNDISTEFTYQTKDAA----TG 107 GG N A LG + V D G+ + +++ + YQTK T Sbjct: 80 GGSAGNTAAGVANLGGKAAYFGNVAADQLGDIFTHDIRAQGVH----YQTKPKGAFPPTA 135 Query: 108 TASIIVNNEGQNIIVIVAGANLLLNTEDLRAAANVISRAKVMVCQLEI-TPATSLEAL-- 164 + I V +G+ + GA + L ED+ A +V++ AKV + + P + EA+ Sbjct: 136 RSMIFVTEDGERSMNTYLGACVELGPEDVEA--DVVADAKVTYFEGYLWDPPRAKEAILD 193 Query: 165 --TMARRSGVKTLFNPAPAIADLDPQFYTLSDVFCCNESEAEILTGLTVGSA-------- 214 +A + G + TLSD FC + E L + G Sbjct: 194 CARIAHQHGREMSM--------------TLSDSFCVDRYRGEFLDLMRSGKVDIVFANRQ 239 Query: 215 -------ADAGEAALVLLKRGCQVVIITLGAEGCVVLSQTEPEPKHIPTEKVK-AVDTTG 266 D E AL + C++ +T+ G V+L E ++ +++ VDTTG Sbjct: 240 EALSLYQTDDFEEALNRIAADCKIAAVTMSENGAVILKGRER--YYVNAIRIREVVDTTG 297 Query: 267 AGDSFVGALAFYLAYYPNLSLEDMLNRSNFIAAVSVQAAGTQ 308 AGD F A F Y SLED A + +Q G + Sbjct: 298 AGDLF--ASGFLYGYTQGRSLEDCGKLGCLAAGIVIQQIGPR 337 >2NWH-A nrPDB Length = 317 Score = 58.2 bits (139), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 79/276 (28%), Positives = 122/276 (44%), Gaps = 28/276 (10%) Query: 52 GGKGANQCVQAARLGAMTSMVCKVGKDSFGNDYIENLKQNDI-STEFTYQTKDAATGTAS 110 GG G N +RLG ++ G D G E +Q + T FT+ + + TA Sbjct: 39 GGGGFNAARNLSRLGFEVRIIAPRGGDVTGEVVAEAARQAGVEDTPFTFLDRRTPSYTA- 97 Query: 111 IIVNNEGQNIIVIVAGANL--LLNTEDL--RAAANVISRAKVMVCQLEITPATSLEALTM 166 I+ +G N+++ +A +L L L RA I + ++C + P +L AL + Sbjct: 98 -ILERDG-NLVIALADMDLYKLFTPRRLKVRAVREAIIASDFLLCDANL-PEDTLTALGL 154 Query: 167 ARRSGVKTL----FNPAPAIADLDPQFYTLSDVFCCNESEAEILTGLTVGSAADAGEAAL 222 R+ K L +PA A+ L + D+ NE+EA LTG T + D Sbjct: 155 IARACEKPLAAIAISPAKAV-KLKAALGDI-DILFMNEAEARALTGETAENVRDWPN--- 209 Query: 223 VLLKRGCQVVIITLGAEGCVVLSQTEPEPKHIP-TEKVKAVDTTGAGDSFVGALAFYLAY 281 +L K G ++T GA V + TE H P +VK D TGAGD+ A + A Sbjct: 210 ILRKAGLSGGVVTRGASEVVAFNGTEKAILHPPLIREVK--DVTGAGDAM--ASGYLAAI 265 Query: 282 YPNLSLEDMLNRSNFIAAVSVQAAGTQSSYPYKKDL 317 ++ + L + AA++V QSS+ +DL Sbjct: 266 AEGKTIREALRQGAAAAAITV-----QSSFATSQDL 296 >2RBC-A nrPDB Length = 343 Score = 58.2 bits (139), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 70/269 (26%), Positives = 112/269 (41%), Gaps = 19/269 (7%) Query: 18 VVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCVQAARLGAMTSMVCKVGK 77 V+ VG+ + D + + +PK + ++ G ++ R+G S+ VG Sbjct: 32 VLCVGAAVLDTLFRVADMPKGEGKVLPYEVLQIAEGMASSAAYAVHRMGGRASLWGAVGD 91 Query: 78 DSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNIIVIVAGANLLLNTEDLR 137 D G + +L ++ I T A + ++II++N G+ +IV L E R Sbjct: 92 DETGTRILRDLSESGIDTSGMTVAPGARSALSTIIIDNRGERLIVPFYDHRL---HEKKR 148 Query: 138 A-AANVISRAKVMVCQLEITPATSLEALTMARRSGVKTLFN----PAPAIADLDPQFYTL 192 A I+ ++ + P +L+ LT+AR G + + P + L P + Sbjct: 149 ACTPEDIALFDAVLVDVRW-PELALDVLTVARALGKPAILDGDVAPVETLEGLAPAATHI 207 Query: 193 SDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVI-ITLGAEGCVVLSQTEPEP 251 VF +E A LTGL + VL R Q I +T G GC +P Sbjct: 208 --VF--SEPAATRLTGLET-----VKDMLPVLHARYPQTFIAVTAGPAGCWWTEADDPTV 258 Query: 252 KHIPTEKVKAVDTTGAGDSFVGALAFYLA 280 T +V+AVDT AGD F G A +A Sbjct: 259 HFQTTMQVEAVDTLAAGDIFHGTFALAMA 287 >4WJM-A nrPDB Length = 312 Score = 53.9 bits (128), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 62/260 (23%), Positives = 98/260 (37%), Gaps = 36/260 (13%) Query: 30 SLTSRLPKTGETIHGHKFFIGF-GGKGANQCVQAARLGAMTSMVCKVGKDSFGNDYIENL 88 +L LP+ ET G F F GG N + RLG T + D FG+ + L Sbjct: 14 ALIDMLPR--ETTGGETAFQPFAGGSVFNTAIALGRLGVPTGFFSGISSDFFGDVLRDTL 71 Query: 89 KQNDISTEFTYQTKDAATGTASIIVNNEGQNIIVIVAGANLLLNTEDLRAAANVISRAKV 148 ++++ F + T +V+ + + A +L+ D+ IS Sbjct: 72 ARSNVDYSFAAISNRPTTLAFVRLVDGQARYAFYDENTAGRMLSRNDMPYVDETISAMLF 131 Query: 149 MVCQLEITPATSLEALTMARRSGVKTLFNPAPAIADLDP------------------QFY 190 L P S+ +AR + + +F LDP + Sbjct: 132 GCISLISEPCGSVYETLLAREAPNRVMF--------LDPNIRANLITVRKTHLTRMKRMI 183 Query: 191 TLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLGAEGCVVLSQTEPE 250 L+D+ ++ + + G E A LK G ++V+IT GA G V + Sbjct: 184 ALADIVKLSDEDLDWF-----GEKGSHDEIAAEWLKLGPKLVVITKGAHGAVAYTNHATV 238 Query: 251 PKHIPTEKVKAVDTTGAGDS 270 P +P KV VDT GAGD+ Sbjct: 239 P--VPGVKVDVVDTVGAGDT 256 >2QCV-A nrPDB Length = 332 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 66/292 (22%), Positives = 122/292 (41%), Gaps = 52/292 (17%) Query: 18 VVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCVQAARLGAMTSMVCKVGK 77 ++ +G DL ++ P ET+ K+ GG AN + +++LG + K+ Sbjct: 14 LIAIGRACIDLNAVEYNRPME-ETMTFSKYV---GGSPANIVIGSSKLGLKAGFIGKIAD 69 Query: 78 DSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQN----------------II 121 D G +IE+ + T++++V+ EG ++ Sbjct: 70 DQHGR-FIESY------------MRGVGVDTSNLVVDQEGHKTGLAFTEIKSPEECSILM 116 Query: 122 VIVAGANLLLNTEDLRAAANVISRAKVMVCQ---LEITPATS--LEALTMARRSGVKTLF 176 A+L L+ E++ A I R+K+++ L +P+ L+A+ +A+R+ VK +F Sbjct: 117 YRQDVADLYLSPEEVNEA--YIRRSKLLLVSGTALSKSPSREAVLKAIRLAKRNDVKVVF 174 Query: 177 --NPAPAIADLDPQ---FYTL----SDVFCCNESEAEILTGLTVGSAADAGEAALVLLKR 227 + P + + +Y+L SD+ E ++L T D E L K Sbjct: 175 ELDYRPYSWETPEETAVYYSLVAEQSDIVIGTREEFDVLENRT--EKGDNDETIRYLFKH 232 Query: 228 GCQVVIITLGAEGCVVLSQTEPEPKHIPTEKVKAVDTTGAGDSFVGALAFYL 279 ++++I G EG ++ E K K + T GAGDS+ A + L Sbjct: 233 SPELIVIKHGVEGSFAYTKA-GEAYRGYAYKTKVLKTFGAGDSYASAFLYAL 283 >2QHP-A nrPDB Length = 296 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 65/244 (26%), Positives = 102/244 (41%), Gaps = 34/244 (13%) Query: 52 GGKGANQCVQAARLGAMTSMVCKVGKDSFGNDYIENLKQNDISTEFTYQTKDAATGTASI 111 GG AN ++ G + +V VG D G++ +E K+ + + + D TGT + Sbjct: 24 GGAPANFAYHVSQFGFDSRVVSAVGNDELGDEIMEVFKEKQLKNQI--ERVDYPTGTVQV 81 Query: 112 IVNNEGQNIIVI---VAGANLLLNTEDLRAAANVISRAKVMVC------QLEITPATSLE 162 +++EG I VA N+ E R A N +RA VC + E++ AT Sbjct: 82 TLDDEGVPCYEIKEGVAWDNIPFTDELKRLALN--TRA---VCFGSLAQRNEVSRATINR 136 Query: 163 AL-TMARRSGVKTLFNPAPAIADLDPQFYTLS---------DVFCCNESEAEILTGLTVG 212 L TM G +F+ +L FYT ++ N+ E ++ + Sbjct: 137 FLDTMPDIDGQLKIFD-----INLRQDFYTKEVLRESFKRCNILKINDEELVTISRMFGY 191 Query: 213 SAADAGEAALVLL-KRGCQVVIITLGAEGCVVLSQTEPEPKHIPTEKVKAVDTTGAGDSF 271 D + +LL K +++I+T G G V + + P KV DT GAGDSF Sbjct: 192 PGIDLQDKCWILLAKYNLKMLILTCGINGSYVFTPGVVSFQETP--KVPVADTVGAGDSF 249 Query: 272 VGAL 275 A Sbjct: 250 TAAF 253 >3IQ0-A nrPDB Length = 330 Score = 51.2 bits (121), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 57/235 (24%), Positives = 95/235 (40%), Gaps = 36/235 (15%) Query: 61 QAARLGAMTSMVCKVGKDSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNI 120 Q RLG ++ VG D FG+ I L + + ATG+A + +N G Sbjct: 46 QVTRLGVPCGIISCVGNDGFGDINIHRLAADGVDIRGISVLPLEATGSAFVTYHNSGDR- 104 Query: 121 IVIVAGANLLLNTEDL---RAAANVISRAKVMVCQLEITPATSL----------EALTMA 167 + + N ++ + +A + + C +SL +A+T+ Sbjct: 105 -------DFIFNIKNAACGKLSAQHVDENILKDCTHFHIMGSSLFSFHMVDAVKKAVTIV 157 Query: 168 RRSGVKTLFNP--------APAIADLDPQFYTLSDVFCCNESEAEILTGLTVGSAADAGE 219 + +G F+P P + D L+D++ +E E +L+ + A AG Sbjct: 158 KANGGVISFDPNIRKEMLDIPEMRDALHFVLELTDIYMPSEGEVLLLSPHSTPERAIAG- 216 Query: 220 AALVLLKRGCQVVIITLGAEGCVVLSQTEPEPKHIPTEKVKAVDTTGAGDSFVGA 274 L+ G + VI+ G +G S E H+ + V+ VD TGAGD F GA Sbjct: 217 ----FLEEGVKEVIVKRGNQGASYYSANEQ--FHVESYPVEEVDPTGAGDCFGGA 265 >2I6B-A nrPDB Length = 345 Score = 50.4 bits (119), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 60/264 (22%), Positives = 110/264 (41%), Gaps = 30/264 (11%) Query: 75 VGKDSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNIIVIVAGANLLLNTE 134 +G D FG + + + Y+ + TGT + + + +++I +A AN + Sbjct: 90 IGIDKFGEILKRKAAEAHVDAHY-YEQNEQPTGTCAACITGDNRSLIANLAAANCYKKEK 148 Query: 135 DLRAAANVISRAKVMVCQ-----LEITPATSLEALTMARRSG-VKTLFNPAPAIADLDPQ 188 L N + K VC L ++P + L+ A + + TL AP I+ Q Sbjct: 149 HLDLEKNWMLVEKARVCYIAGFFLTVSPESVLKVAHHASENNRIFTLNLSAPFIS----Q 204 Query: 189 FYTLS--------DVFCCNESEAEILT---GLTVGSAADAGEAALVLLK---RGCQVVII 234 FY S D+ NE+EA G + + L K + ++VI Sbjct: 205 FYKESLMKVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIF 264 Query: 235 TLGAEGCVVLSQTEPEPKHIPTEKVKAV-DTTGAGDSFVGALAFYLAYYPNLSLEDMLNR 293 T G + ++ +++E + + K + DT GAGD+FVG F + L + + Sbjct: 265 TQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAFVG--GFLSQLVSDKPLTECIRA 322 Query: 294 SNFIAAVSVQAAGTQSSYPYKKDL 317 ++ A++ ++ G ++P K D Sbjct: 323 GHYAASIIIRRTG--CTFPEKPDF 344 >3PL2-A nrPDB Length = 319 Score = 48.1 bits (113), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 72/272 (26%), Positives = 114/272 (41%), Gaps = 39/272 (14%) Query: 51 FGGKGANQCVQAARLGAMTSMVCKVGKDSFGNDYIENLKQNDISTEF--TYQTKDAATGT 108 GG AN V AAR G ++++ +VG D FG + L++ + ++ T QT Sbjct: 40 LGGSAANVSVAAARHGHNSALLSRVGNDPFGEYLLAELERLGVDNQYVATDQTFKTPVTF 99 Query: 109 ASIIVNNEGQNIIVIVAGANLLLNTEDLRAAANVISRAKVMVCQL-----EITPATSLEA 163 I ++ A L N E + + + A ++ L E + T E Sbjct: 100 CEIFPPDDFPLYFYREPKAPDL-NIESADVSLDDVREADILWFTLTGFSEEPSRGTHREI 158 Query: 164 LTMARRSGVKTLFNPAPAIADLDPQFY--------------TLSDVFCCNESEAEILTGL 209 LT R + T+F+ D P F+ S V N+ E EI G Sbjct: 159 LT-TRANRRHTIFD-----LDYRPMFWESPEEATKQAEWALQHSTVAVGNKEECEIAVGE 212 Query: 210 TVGSAADAGEAALVLLKRGCQVVIITLGAEGCVVLSQTEPEPKHIPTEKVKAVDTTGAGD 269 T + A LL+RG ++ I+ G +G V++ T+ E +P V ++ GAGD Sbjct: 213 T-----EPERAGRALLERGVELAIVKQGPKG--VMAMTKDETVEVPPFFVDVINGLGAGD 265 Query: 270 SFVGALAF-YLAYYPNLSLEDMLNRSNFIAAV 300 +F GAL L+ +P LE +L +N A+ Sbjct: 266 AFGGALCHGLLSEWP---LEKVLRFANTAGAL 294 >3LJS-A nrPDB Length = 338 Score = 47.8 bits (112), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 63/249 (25%), Positives = 102/249 (40%), Gaps = 31/249 (12%) Query: 52 GGKGANQCVQAARLGAMTSMVCKVGKDSFGNDYIENLKQNDISTEFTYQTKDAATGTASI 111 GG AN V ARLG V +G D FG+ ++ + + T+ +T A T A + Sbjct: 36 GGAPANVAVAVARLGGAVQFVGMLGSDMFGDFLFDSFAEAGVVTDGIVRTSTAKTALAFV 95 Query: 112 IVNNEGQNIIVIV--AGANLLLNTEDLRAAANVISRAKVM-VCQLEITPA----TSLEAL 164 ++ G+ A+LL E + A+ S A + C +T A + E + Sbjct: 96 ALDAHGERSFSFYRPPAADLLFRVEHFQDAS--FSDALIFHACSNSMTDADIAEVTFEGM 153 Query: 165 TMARRSGVKTLF-------------NPAPAIADLDPQFYTLSDVFCCNESEAEILTGLTV 211 A+ +G F NPA + + +L+DV + E + L Sbjct: 154 RRAQAAGAIVSFDLNFRPMLWPNGENPASRLW----KGLSLADVVKLSSEELDYLANTL- 208 Query: 212 GSAADAGEAALVLLKRGCQVVIITLGAEGCVVLSQTEPEPKHIPTEKVKAVDTTGAGDSF 271 AADA L + Q++++T A V T +PT +V+ D+ AGD+F Sbjct: 209 --AADANAVIQQLWQGRAQLLLVTDAA--GPVHWYTRTAGGEVPTFRVQVQDSNAAGDAF 264 Query: 272 VGALAFYLA 280 VG + + A Sbjct: 265 VGGMLYTFA 273 >2C4E-A nrPDB Length = 302 Score = 47.4 bits (111), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 71/312 (22%), Positives = 118/312 (37%), Gaps = 40/312 (12%) Query: 14 EVAAVVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCVQAARLGAMTSMVC 73 ++ + VG D + + P+ +I +GG AN V +LG + ++ Sbjct: 4 KMEKITCVGHTALDYIFNVEKFPEPNTSIQIPSARKYYGGAAANTAVGIKKLGVNSELLS 63 Query: 74 KVGKDSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNIIVIVAGANLL--- 130 VG D + Y LK DI+ Y +++ T A I + + I + GA Sbjct: 64 CVGYDFKNSGYERYLKNLDINISKLYYSEEEETPKAWIFTDKDNNQITFFLWGAAKHYKE 123 Query: 131 -----LNTEDLRAAANVISRAKVMVCQLEITPATSLEALTMARRSGVKTLFNPAPAIADL 185 NTE + A P +L+ A + + + F+P + Sbjct: 124 LNPPNFNTEIVHIATG--------------DPEFNLKCAKKAYGNNLVS-FDPGQDLPQY 168 Query: 186 DPQFY----TLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLGAEGC 241 + ++ N+ E E + L D L+R +I+T G++G Sbjct: 169 SKEMLLEIIEHTNFLFMNKHEFERASNLLNFEIDD-------YLER-VDALIVTKGSKGS 220 Query: 242 VVLSQTEPEPKHIPTEKV-KAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFIAAV 300 V+ T+ + IP K K +D TGAGDS+ F AY LE A+ Sbjct: 221 VIY--TKDKKIEIPCIKAGKVIDPTGAGDSYRA--GFLSAYVKGYDLEKCGLIGAATASF 276 Query: 301 SVQAAGTQSSYP 312 V+A G Q++ P Sbjct: 277 VVEAKGCQTNLP 288 >3N1C-A nrPDB Length = 309 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 64/261 (24%), Positives = 106/261 (40%), Gaps = 41/261 (15%) Query: 52 GGKGANQCVQAARLGAMTSMVCKVGKDSFGNDYIENLKQNDISTEFTYQTKDAATGTASI 111 GG G N A LG + + G + G + L ++ T + KD + Sbjct: 38 GGGGINVARAIAHLGGSATAIFPAG-GATGEHLVSLLADENVPVA-TVEAKDWTRQNLHV 95 Query: 112 IVNNEGQNIIVIVAGANLLLNTEDLRAAANV---ISRAKVMVCQLEITPATSLEALTM-- 166 V G+ ++ GA LN ++ R I ++V + P LE LT Sbjct: 96 HVEASGEQYRFVMPGA--ALNEDEFRQLEEQVLEIESGAILVISGSLPPGVKLEKLTQLI 153 Query: 167 --ARRSGVKTL-------FNPAPAIADLDPQFYTLSDVFCCNESEAEILTGLTVGSAADA 217 A++ G++ + + A AI +++ + N+ E L + D Sbjct: 154 SAAQKQGIRCIVDSSGEALSAALAIGNIE--------LVKPNQKELSALVNRELTQPDDV 205 Query: 218 GEAALVLLKRG-CQVVIITLGAEGCVVLS-----QTEPEPKHIPTEKVKAVDTTGAGDSF 271 +AA ++ G + V+++LG +G + + Q P P VK+ T GAGDS Sbjct: 206 RKAAQEIVNSGKAKRVVVSLGPQGALGVDSENCIQVVPPP-------VKSQSTVGAGDSM 258 Query: 272 VGALAFYLAYYPNLSLEDMLN 292 VGA+ LA N SLE+M+ Sbjct: 259 VGAMTLKLAE--NASLEEMVR 277 >4DU5-A nrPDB Length = 336 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 73/330 (22%), Positives = 113/330 (34%), Gaps = 57/330 (17%) Query: 18 VVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCVQAARLGAMTSMVCKVGK 77 V+ G M LV+ + G H F G N + ARLG ++G Sbjct: 29 VITFGEAMMLLVA-----DRPGPLEHAEAFHKRTAGAETNVAIGLARLGLKVGWASRLGT 83 Query: 78 DSFGNDYIENLKQNDIS-----------TEFTYQTKDAATGTASIIVNNEGQNIIVIVAG 126 DS G + + I T F ++ K + + +G Sbjct: 84 DSMGRYLLAAMAAEGIDCSHVVCDATQKTGFQFKGKVTDGSDPPVEYHRKGS-------- 135 Query: 127 ANLLLNTEDLRAAANVISRAKVMVCQLEITPATSLEA----LTMARRSGVKTLFNPAPAI 182 A + D+ A + +R AT+L A + + R +G F+P Sbjct: 136 AASHMGVADIDEAWLLSARHLHATGVFPAISATTLPAARKTMDLMRAAGRSVSFDP---- 191 Query: 183 ADLDPQFY--------------TLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRG 228 +L P + T +D E LTG T A + G Sbjct: 192 -NLRPTLWATPELMRDAINDLATRADWVLPGMEEGRFLTGETTPEGV-----ARFYRQLG 245 Query: 229 CQVVIITLGAEGCVVLSQT-EPEPKHIPTEKVKAVDTTGAGDSFVGALAFYLAYYPNLSL 287 ++V++ LGAEG + P +V VDT GAGD F A+ A L + Sbjct: 246 AKLVVVKLGAEGAYFDGEAGSGRVAGFPVAEV--VDTVGAGDGF--AVGVISALLDGLGV 301 Query: 288 EDMLNRSNFIAAVSVQAAGTQSSYPYKKDL 317 + + R +I A +VQ G P + +L Sbjct: 302 PEAVKRGAWIGARAVQVLGDSEGLPTRAEL 331 >3LHX-A nrPDB Length = 319 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 78/318 (24%), Positives = 122/318 (38%), Gaps = 52/318 (16%) Query: 18 VVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCVQAARL---GAMT-SMVC 73 + V+G CM +L + + + GFGG N V AR A+T V Sbjct: 7 IAVIGECMIELSEKGADVKR------------GFGGDTLNTSVYIARQVDPAALTVHYVT 54 Query: 74 KVGKDSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNIIVIV---AGANLL 130 +G DSF ++ ++ T T + ++ G I ++ G+ A A Sbjct: 55 ALGTDSFSQQMLDAWHGENVDTSLTQRMENRLPGLYYIETDSTGERTFYYWRNEAAAKFW 114 Query: 131 LNTEDLRAAANVISRAKVMV---CQLEITPATSLEAL----TMARRSGVKTLF--NPAPA 181 L +E A ++ + L I TS E L R G K +F N P Sbjct: 115 LASEQSAAICEELANFDYLYLSGISLAILSPTSREKLLSLLRECRAKGGKVIFDNNYRPR 174 Query: 182 I-------ADLDPQFYTLSDVFCCNESEAEILTGL-----TVGSAADAGEAALVLLKRGC 229 + + Q +D+ + + L G + +AG V++KRG Sbjct: 175 LWASKEETQQVYQQMLECTDIAFLTLDDEDALWGQQPVEDVIARTHNAG-VKEVVVKRGA 233 Query: 230 QVVIITLGAEGCVVLSQTEPEPKHIPTEKVKAVDTTGAGDSF-VGALAFYLAYYPNLSLE 288 ++++ E V + P K +P EKV +DTT AGDSF G LA L S E Sbjct: 234 DSCLVSIAGEALVDV----PAVK-LPKEKV--IDTTAAGDSFSAGYLAVRLT---GGSAE 283 Query: 289 DMLNRSNFIAAVSVQAAG 306 + R + A+ +Q G Sbjct: 284 NAAKRGHLTASTVIQYRG 301 >1WYE-A nrPDB Length = 311 Score = 45.8 bits (107), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 69/322 (21%), Positives = 126/322 (39%), Gaps = 39/322 (12%) Query: 15 VAAVVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCVQAARLGAMTSMVCK 74 +A ++ +G + + +L+ G H F G AN CV + G ++ K Sbjct: 1 MAKLITLGEILIEFNALS-----PGPLRHVSYFEKHVAGSEANYCVAFIKQGNECGIIAK 55 Query: 75 VGKDSFGNDYIENLKQNDISTEFTYQTKDAATGTASII----VNNEGQNIIVIVAGANLL 130 VG D FG + IE L+ + A TG I V + ++I A Sbjct: 56 VGDDEFGYNAIEWLRGQGVDVSHMKIDPSAPTGIFFIQRHYPVPLKSESIYYRKGSAGSK 115 Query: 131 LNTEDLR----AAANVISRAKVMVCQLEITPATSLEALTMARRSGVKT-----LFNPAPA 181 L+ ED+ +A+++ + + + +A +A T L++ A Sbjct: 116 LSPEDVDEEYVKSADLVHSSGITLAISSTAKEAVYKAFEIASNRSFDTNIRLKLWSAEEA 175 Query: 182 ---IADLDPQFYTLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLGA 238 I L +F+ + +++I+ G +D +AA +++++ LG Sbjct: 176 KREILKLLSKFHL--KFLITDTDDSKIILG-----ESDPDKAAKAFSDY-AEIIVMKLGP 227 Query: 239 EGCVVL---SQTEPEPKHIPTEKVKAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSN 295 +G +V + +P E D TGAGD+ G F YY +E L+ + Sbjct: 228 KGAIVYYDGKKYYSSGYQVPVE-----DVTGAGDALGGT--FLSLYYKGFEMEKALDYAI 280 Query: 296 FIAAVSVQAAGTQSSYPYKKDL 317 + ++V G Q + P KD+ Sbjct: 281 VASTLNVMIRGDQENLPTTKDI 302 >3LOO-A nrPDB Length = 365 Score = 44.7 bits (104), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 57/223 (25%), Positives = 96/223 (43%), Gaps = 27/223 (12%) Query: 75 VGKDSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNIIVIVAGANLLLNTE 134 VG+D + E N ++ ++ ++ + TGT +++V +++ +A AN E Sbjct: 106 VGQDEYARILEERATSNGVNVQYQ-RSATSPTGTCAVLVTGTQRSLCANLAAANDF-TPE 163 Query: 135 DLRAAANVISRAKVMVCQLEITPA----TSLE-ALTMARRSGVKTLFNPAPAIADLDPQF 189 LR+ N RA + Q S E AL++A+ + A PQF Sbjct: 164 HLRSDGN---RAYLQGAQFFYVSGFFFTVSFESALSVAKEAAATGRMFMMNLSAPFVPQF 220 Query: 190 YT--------LSDVFCCNESEAEILTG-LTVGSA--ADAGEAALVLLK---RGCQVVIIT 235 Y DV NE+EA L G+ + G+ L K + ++VIIT Sbjct: 221 YKNNLEEIFPYVDVLFGNETEAIALAKEFNYGTEDLREIGKRIAALPKENGKRKRIVIIT 280 Query: 236 LGAEGCVVLSQTEPEPKHIPTEKV---KAVDTTGAGDSFVGAL 275 G++ +++ + P +K+ + VDT GAGD+FVG Sbjct: 281 QGSDPVLLIEAGTDNVREFPVQKLAPEQMVDTNGAGDAFVGGF 323 >2JG5-A nrPDB Length = 306 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 31/100 (31%), Positives = 51/100 (51%), Gaps = 12/100 (12%) Query: 199 NESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLGAEGCVVLSQTEPEPKHIPTEK 258 N+ E E++ TV S AD + +L+ +G Q VI++LG +G + + K I + Sbjct: 181 NKDELEVMFNTTVNSDADVIKYGRLLVDKGAQSVIVSLGGDGAIYID------KEISIKA 234 Query: 259 V----KAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRS 294 V K V+T G+GDS V + +A LS+E ++ Sbjct: 235 VNPQGKVVNTVGSGDSTVAGMVAGIA--SGLSIEKAFQQA 272 >4N08-A nrPDB Length = 348 Score = 41.6 bits (96), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 66/289 (22%), Positives = 116/289 (40%), Gaps = 36/289 (12%) Query: 52 GGKGAN-----QCVQAARLGAMTSMVCKVGKDSFGNDYIENLKQNDISTEFTYQTKDAAT 106 GG G N Q +Q A G + V + D +G E + I + TK A + Sbjct: 65 GGSGLNVARVAQWMQQAYKGKFVTYVGCIADDRYGKVLKEAAEHEGIVMAVEHTTK-AGS 123 Query: 107 GTASIIVNNEGQNIIVIVAGANLLLNTEDLRAAANV--ISRAKVMVCQ---LEITPATSL 161 G ++ + + + ++ + AN L ++E +R+ A V + +++ L + L Sbjct: 124 GACAVCITGKERTLVADLGAANHL-SSEHMRSPAVVRAMDESRIFYFSGFTLTVDVNHVL 182 Query: 162 EALTMARR-SGVKTLFNPAPAIADLDPQFYT--------LSDVFCCNESEAEILTGLT-- 210 +A AR G+ + AP I QF++ +D+ N EA+ + Sbjct: 183 QACRKAREVDGLFMINLSAPFIM----QFFSAQLGEVLPYTDIIVANRHEAKEFANMMKW 238 Query: 211 ----VGSAADAGEAALVLLKRGCQVVIITLGAEGCVVLSQTEPEPKHIPT-EKVKAVDTT 265 V A + + +VV+ T E V+ ++ E +P ++ K +D Sbjct: 239 DTDCVEEIARRAVSEVPYTGTKGRVVVFTRDIESTVLATKDGVETVPVPQLDQDKVIDMN 298 Query: 266 GAGDSFVGALAFYLAYYPNLSLEDMLNRSNFIAAVSVQAAGTQSSYPYK 314 GAGD+F+G F AY L ++ A +Q G S+P K Sbjct: 299 GAGDAFMG--GFLSAYAVGKDLRRCCETGHYTAQEVIQRDGC--SFPEK 343 >5KB6-A nrPDB Length = 363 Score = 41.6 bits (96), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 59/264 (22%), Positives = 111/264 (42%), Gaps = 30/264 (11%) Query: 75 VGKDSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNIIVIVAGANLLLNTE 134 +G D FG + + Y+ + TGT + + ++++ +A AN + Sbjct: 108 IGIDKFGEILKRKAADAHVDAHY-YEQNEQPTGTCAACITGGNRSLVANLAAANCYKKEK 166 Query: 135 DLRAAAN--VISRAKVMVCQ---LEITPATSLE-ALTMARRSGVKTLFNPAPAIADLDPQ 188 L N ++ +A+V L ++P + L+ A A + V TL AP I+ Q Sbjct: 167 HLDLERNWVLVEKARVYYIAGFFLTVSPESVLKVARYAAENNRVFTLNLSAPFIS----Q 222 Query: 189 FYTLS--------DVFCCNESEAEILT---GLTVGSAADAGEAALVLLK---RGCQVVII 234 F+ + D+ NE+EA G + + A L K + + VI Sbjct: 223 FFKEALMDVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKAQALPKVNSKRQRTVIF 282 Query: 235 TLGAEGCVVLSQTEPEPKHIPTE-KVKAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNR 293 T G + +V ++ + + + + + +DT GAGD+FVG F + L + + Sbjct: 283 TQGRDDTIVAAENDVTAFPVLDQNQEEIIDTNGAGDAFVG--GFLSQLVSDKPLTECIRA 340 Query: 294 SNFIAAVSVQAAGTQSSYPYKKDL 317 ++ A+V ++ G ++P K D Sbjct: 341 GHYAASVIIRRTGC--TFPEKPDF 362 >2HW1-A nrPDB Length = 298 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 57/287 (19%), Positives = 110/287 (38%), Gaps = 39/287 (13%) Query: 14 EVAAVVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCVQAARLGAMTSMVC 73 E ++ VG + D++SL + PK I GG +N C + LGA + + Sbjct: 2 EEKQILCVGLVVLDVISLVDKYPKEDSEIRCLSQRWQRGGNASNSCTVLSLLGAPCAFMG 61 Query: 74 KVGKDSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNIIVIVAGANLLLNT 133 + + +++L++ + +T + A++I+N +G+ +L Sbjct: 62 SMAPGHVADFVLDDLRRYSVDLRYTVFQTTGSVPIATVIINE--------ASGSRTILYY 113 Query: 134 EDLRAAANVISRAKVMVCQ---LEITPATSLEALTMARRSGVKTLFNPAP-----AIADL 185 + + KV + Q + I + E + M +R P ++ Sbjct: 114 DRSLPDVSATDFEKVDLTQFKWIHIEGRNASEQVKMLQRIDAHNTRQPPEQKIRVSVEVE 173 Query: 186 DP-----QFYTLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVII------ 234 P Q + DV ++ ++ L SA +A +++G +V Sbjct: 174 KPREELFQLFGYGDVVFVSK---DVAKHLGFQSAEEALRGLYGRVRKGAVLVCAWAEEGA 230 Query: 235 -TLGAEGCVVLSQTEPEPKHIPTEKVKAVDTTGAGDSFVGALAFYLA 280 LG +G ++ S P P + VDT GAGD+F ++ F L+ Sbjct: 231 DALGPDGKLLHSDAFPPP--------RVVDTLGAGDTFNASVIFSLS 269 >3UQ9-A nrPDB Length = 372 Score = 39.3 bits (90), Expect = 0.002, Method: Compositional matrix adjust. Identities = 65/267 (24%), Positives = 117/267 (43%), Gaps = 23/267 (8%) Query: 70 SMVCKVGKDSFGNDYIEN-LKQNDISTEFTYQTKDAATGTASIIVNNEGQNIIVIVAGA- 127 S V +G D G YI+N D+ TEF + TG +++V+ + ++++ + A Sbjct: 104 SYVGCIGADIQGK-YIKNDCSALDLVTEFQIAEEPLMTGKVAVLVSEKLRSMVTYLGAAC 162 Query: 128 NLLLNTEDLRAAANVISRAKVMVCQLEITPATSLEALTMARRS--GVKTL-FN-PAPAIA 183 +L L + +++ +A+V + L +A+ S K FN AP ++ Sbjct: 163 DLSLAHIEQPHVWSLVEKAQVYYIAGFVINTCYEGMLKIAKHSLENEKLFCFNLSAPFLS 222 Query: 184 DLD----PQFYTLSDVFCCNESEAE-------ILTGLTVGSAADAGEAALVLLKRGCQVV 232 + + + S++ NESEAE +L +A + K+ ++V Sbjct: 223 QFNTKEVDEMISYSNIVFGNESEAEAYGEVHGLLEDTVHATARYIADLPFADGKKRKRLV 282 Query: 233 IITLGAEGCVVLSQTEPEPKHIPTEKVK---AVDTTGAGDSF-VGALAFYLAYYPNL-SL 287 IIT G + ++ E E+ K +DT GAGD+F G +A Y+ P + SL Sbjct: 283 IITRGKNPLLYTDSSDSEIHQFMVEQFKDDQIIDTNGAGDAFAAGFIADYIRGKPMITSL 342 Query: 288 EDMLNRSNFIAAVSVQAAGTQSSYPYK 314 + + +I S + G++ SY K Sbjct: 343 HAAVKAAAYIICRSGFSLGSRDSYSLK 369 >3KD6-A nrPDB Length = 313 Score = 39.3 bits (90), Expect = 0.003, Method: Compositional matrix adjust. Identities = 31/99 (31%), Positives = 48/99 (48%), Gaps = 10/99 (10%) Query: 194 DVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLGAEGCVVLSQTE--PEP 251 DVF N+SEA +L+G + + A ++ + G + +II G G ++ + P Sbjct: 170 DVFIVNDSEARLLSG-----DPNLVKTARIIREMGPKTLIIKKGEHGALLFTDNGIFAAP 224 Query: 252 KHIPTEKVKAVDTTGAGDSFVGALAFYLAYYPNLSLEDM 290 P E + D TGAGD+F G +LA N S +M Sbjct: 225 A-FPLESI--YDPTGAGDTFAGGFIGHLARCGNTSEAEM 260 >2VAR-A nrPDB Length = 313 Score = 38.9 bits (89), Expect = 0.003, Method: Compositional matrix adjust. Identities = 63/279 (22%), Positives = 108/279 (38%), Gaps = 34/279 (12%) Query: 25 MTDLVSLTSRLPKTGETIHGHKFFIGF-----GGKGANQCVQAARLGAMTSMVCKVGKDS 79 M D+++L L + G F+ + G N C+ R S++ +VG D Sbjct: 1 MVDVIALGEPLIQFNSFNPGPLRFVNYFEKHVAGSELNFCIAVVRNHLSCSLIARVGNDE 60 Query: 80 FGNDYIENLKQNDISTEFTYQTKDAATGTASI----IVNNEGQNIIVIVAGANLLLNTED 135 FG + IE + I T ++ TG I + + + + A L+ ED Sbjct: 61 FGKNIIEYSRAQGIDTSHIKVDNESFTGIYFIQRGYPIPMKSELVYYRKGSAGSRLSPED 120 Query: 136 LRAAANVISRAKVMVCQLEITPATS-------LEALTMARRSGVKTLFNPAPAIADLDPQ 188 + N + ++ +V IT A S ++A +A+ + T P + + Sbjct: 121 IN--ENYVRNSR-LVHSTGITLAISDNAKEAVIKAFELAKSRSLDTNIRPKLWSSLEKAK 177 Query: 189 FYTLS-------DVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLGAEGC 241 LS +V + + +IL +T D EA + G +V++ LG++G Sbjct: 178 ETILSILKKYDIEVLITDPDDTKILLDVT-----DPDEAYRKYKELGVKVLLYKLGSKGA 232 Query: 242 VVLSQTEPEPKHIPTEKVKAVDTTGAGDSFVGAL-AFYL 279 + K KV D TGAGD+ G + YL Sbjct: 233 IAYKDNVKAFKD--AYKVPVEDPTGAGDAMAGTFVSLYL 269 >3NCA-A nrPDB Length = 313 Score = 38.9 bits (89), Expect = 0.003, Method: Compositional matrix adjust. Identities = 58/286 (20%), Positives = 111/286 (38%), Gaps = 41/286 (14%) Query: 16 AAVVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCVQAARLGAMTSMVCKV 75 + ++ VG + D++SL + PK I GG +N C + LGA + + + Sbjct: 19 SQILCVGLVVLDVISLVDKYPKEDSEIRCLSQRWQRGGNASNSCTVLSLLGAPCAFMGSM 78 Query: 76 GKDSFGNDYIENLKQNDIS-TEFTYQTKDAATGTASIIVNNEGQNIIVIVAGANLLLNTE 134 + + + ++ + ++ +Q+K + II N+ G IV+ + ++ Sbjct: 79 APGHVADFLVADFRRRGVDVSQVAWQSKGDTPSSCCIINNSNGNRTIVLHDTSLPDVSAT 138 Query: 135 DLRAAANVISRAKVMVCQ---LEITPATSLEALTMARRSGVKTLFNPAP-----AIADLD 186 D KV + Q + I + E + M +R P ++ Sbjct: 139 DFE---------KVDLTQFKWIHIEGRNASEQVKMLQRIDAHNTRQPPEQKIRVSVEVEK 189 Query: 187 P-----QFYTLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVII------- 234 P Q + DV ++ ++ L SA +A +++G +V Sbjct: 190 PREELFQLFGYGDVVFVSK---DVAKHLGFQSAEEALRGLYGRVRKGAVLVCAWAEEGAD 246 Query: 235 TLGAEGCVVLSQTEPEPKHIPTEKVKAVDTTGAGDSFVGALAFYLA 280 LG +G ++ S P P + VDT GAGD+F ++ F L+ Sbjct: 247 ALGPDGKLLHSDAFPPP--------RVVDTLGAGDTFNASVIFSLS 284 >3B1N-A nrPDB Length = 326 Score = 37.4 bits (85), Expect = 0.008, Method: Compositional matrix adjust. Identities = 56/276 (20%), Positives = 107/276 (38%), Gaps = 31/276 (11%) Query: 51 FGGKGANQCVQAARLGAMTSMVCKVGKDSFGNDYIENLKQNDISTEFTYQTKDAATGTAS 110 FGG N LG M+ +G Y++ + +S E+ D + A Sbjct: 46 FGGCAGNIAYALNLLGGDARMMGTLGAVD-AQPYLDRMDALGLSREYVRVLPDTYSAQAM 104 Query: 111 IIVNNEGQNIIVIVAGANLLLNTEDLRAAANVISRAKVMVCQLEITPATSLEALTMAR-- 168 I + + I GA + ++ N AK + +L I + + Sbjct: 105 ITTDLDNNQITAFHPGAMM-------QSHVNHAGEAKDI--KLAIVGPDGFQGMVQHTEE 155 Query: 169 --RSGVKTLFNPAPAIADLD----PQFYTLSDVFCCNESEAEILTGLTVGSAADAGEAAL 222 ++GV +F+P + D + L+ N+ EA+++ T G + D Sbjct: 156 LAQAGVPFIFDPGQGLPLFDGATLRRSIELATYIAVNDYEAKLVCDKT-GWSEDE----- 209 Query: 223 VLLKRGCQVVIITLGAEGCVVLSQTEPEPKHIPTEKV-KAVDTTGAGDSFVGALAFYLAY 281 + Q +IIT G G + + E IP + + +D TG GD+F G L + + + Sbjct: 210 --IASRVQALIITRGEHGATIRHRDGTE--QIPAVRAERVIDPTGCGDAFRGGLLYGIEH 265 Query: 282 YPNLSLEDMLNRSNFIAAVSVQAAGTQSSYPYKKDL 317 + + L ++ + A+ + G Q+ P + ++ Sbjct: 266 GFDWATAGRL--ASLMGALKIAHQGPQTYAPTRAEI 299 >1YGJ-A nrPDB Length = 312 Score = 37.0 bits (84), Expect = 0.012, Method: Compositional matrix adjust. Identities = 36/133 (27%), Positives = 54/133 (40%), Gaps = 17/133 (12%) Query: 168 RRSGVKTLFNPAPAIADLDPQFYTLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKR 227 +R+G ++ P + + ++D+ N+ EAE+LTG + S +A E +L Sbjct: 119 QRNGEGAMYVPDDLLPVYREKVVPVADIITPNQFEAELLTGRKIHSQEEALEVMDMLHSM 178 Query: 228 GCQVVIIT----LGAEGCVVL----SQTEPEPK--------HIPTEKVKAVDTTGAGDSF 271 G V+IT L G L SQ P + KV AV G GD F Sbjct: 179 GPDTVVITSSNLLSPRGSDYLMALGSQRTRAPDGSVVTQRIRMEMHKVDAV-FVGTGDLF 237 Query: 272 VGALAFYLAYYPN 284 L + +PN Sbjct: 238 AAMLLAWTHKHPN 250 >2F7K-A nrPDB Length = 327 Score = 35.8 bits (81), Expect = 0.029, Method: Compositional matrix adjust. Identities = 38/161 (23%), Positives = 67/161 (41%), Gaps = 20/161 (12%) Query: 168 RRSGVKTLFNPAPAIADLDPQFYTLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKR 227 + G +++ P + + L+D+ N+ EAE+L+G + S +A +L Sbjct: 134 KWDGEGSMYVPEDLLPVYKEKVVPLADIITPNQFEAELLSGRKIHSQEEALRVMDMLHSM 193 Query: 228 GCQVVIIT-------LGAEGCVVL-SQTEPEPK--------HIPTEKVKAVDTTGAGDSF 271 G V+IT G+ +VL SQ P + KV AV G GD F Sbjct: 194 GPDTVVITSSDLPSPQGSNYLIVLGSQRRRNPAGSVVMERIRMDIRKVDAV-FVGTGDLF 252 Query: 272 VGALAFYLAYYPN---LSLEDMLNRSNFIAAVSVQAAGTQS 309 L + +PN ++ E ++ + + ++Q A Q+ Sbjct: 253 AAMLLAWTHKHPNNLKVACEKTVSTLHHVLQRTIQCAKAQA 293 >3BF5-A nrPDB Length = 306 Score = 33.5 bits (75), Expect = 0.14, Method: Compositional matrix adjust. Identities = 36/136 (26%), Positives = 57/136 (41%), Gaps = 24/136 (17%) Query: 158 ATSLEALTMARRSGVKTLFNPAPAI----ADLDPQFYTLSDVFCCNESEAEILTGLTVGS 213 +T L MA+ K +F+P+ I D +F+ +S + N+ E + +T S Sbjct: 147 STGPNYLDMAKSIRSKIIFDPSQEIHKYSKDELKKFHEISYMSIFNDHEYRVFREMTGLS 206 Query: 214 AADAGEAALVLLKRGCQVVIITLGAEGC-VVLSQTEPEPKHIPTEKVKAVDTTGAGDSFV 272 + I+T G G + + + + IP+ + DT GAGDSF Sbjct: 207 SPKV-------------TTIVTNGERGSSLFMDGKKYDFPAIPS----SGDTVGAGDSFR 249 Query: 273 GALAFYLAYYPNLSLE 288 L YLA Y S+E Sbjct: 250 AGL--YLALYNRRSIE 263 >2AFB-A nrPDB Length = 351 Score = 32.7 bits (73), Expect = 0.23, Method: Compositional matrix adjust. Identities = 71/318 (22%), Positives = 111/318 (34%), Gaps = 47/318 (14%) Query: 18 VVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCVQAARLGAMTSMVCKVGK 77 VV G M L P F + +GG AN A++G V K+ Sbjct: 15 VVTFGEIMLRLSP-----PDHKRIFQTDSFDVTYGGAEANVAAFLAQMGLDAYFVTKLPN 69 Query: 78 DSFGNDYIENLKQNDISTEFT---------YQTKDAATGTASIIVNNEGQNIIVIVAGAN 128 + G+ +L++ + T++ Y + A+ S +V + + I + Sbjct: 70 NPLGDAAAGHLRKFGVKTDYIARGGNRIGIYFLEIGASQRPSKVVYDRAHSAISEAKRED 129 Query: 129 LLLNTEDLRAAANVISRAKVMVCQLEITPATSLEALTMARRSGVKT---------LFNPA 179 + E + A + + + P +AL +A GV L+ Sbjct: 130 F--DWEKILDGARWFHFSGITPPLGKELPLILEDALKVANEKGVTVSCDLNYRARLWTKE 187 Query: 180 PAIADLDPQFYTLSDVFCCNESEAEILTGLTV----------GSAADAGEAALVLLKRGC 229 A + P F DV NE + E + G++V A A A V K Sbjct: 188 EAQKVMIP-FMEYVDVLIANEEDIEKVLGISVEGLDLKTGKLNREAYAKIAEEVTRKYNF 246 Query: 230 QVVIITLG------AEGCVVLSQTEPEPKHIPTEKVKAVDTTGAGDSFVGALAFYLAYYP 283 + V ITL V+ +P ++ VD GAGDSF GAL Y Sbjct: 247 KTVGITLRESISATVNYWSVMVFENGQPHFSNRYEIHIVDRVGAGDSFAGALI-----YG 301 Query: 284 NLSLEDMLNRSNFIAAVS 301 +L D ++ F AA S Sbjct: 302 SLMGFDSQKKAEFAAAAS 319 >2AWD-A nrPDB Length = 323 Score = 31.6 bits (70), Expect = 0.45, Method: Compositional matrix adjust. Identities = 16/53 (30%), Positives = 30/53 (56%), Gaps = 2/53 (3%) Query: 228 GCQVVIITLGAEGCVVLSQTEPEPKHIPTEKVKAVDTTGAGDSFVGALAFYLA 280 G + ++I+LG +G + + IPT ++A + G+GD+ + LA+ LA Sbjct: 218 GIEWIVISLGKDGAIAKHHDQFYRVKIPT--IQAKNPVGSGDATIAGLAYGLA 268 >1HKH-A nrPDB Length = 279 Score = 29.6 bits (65), Expect = 1.8, Method: Compositional matrix adjust. Identities = 20/79 (25%), Positives = 34/79 (43%), Gaps = 5/79 (6%) Query: 205 ILTGLTVGSAADAGEAALVLLKRGCQ-VVIITLGAEGCVVLSQTEPEPKHIPTEKVKAVD 263 +L G ++G+ GE A + + G + V + A L Q + P+ +P E ++ Sbjct: 93 VLVGFSMGT----GELARYVARYGHERVAKLAFLASLEPFLVQRDDNPEGVPQEVFDGIE 148 Query: 264 TTGAGDSFVGALAFYLAYY 282 GD F FY +Y Sbjct: 149 AAAKGDRFAWFTDFYKNFY 167 >4GM6-A nrPDB Length = 351 Score = 29.3 bits (64), Expect = 2.3, Method: Compositional matrix adjust. Identities = 16/55 (29%), Positives = 26/55 (47%) Query: 49 IGFGGKGANQCVQAARLGAMTSMVCKVGKDSFGNDYIENLKQNDISTEFTYQTKD 103 I GG AN V ++LG T + V + G +E+L ++ + T F + D Sbjct: 53 IHIGGAEANVAVNLSKLGHPTRIATVVPANPIGKMAVEHLWRHQVDTAFVVEAGD 107 >2AA0-A nrPDB Length = 383 Score = 28.9 bits (63), Expect = 3.5, Method: Compositional matrix adjust. Identities = 12/21 (57%), Positives = 15/21 (71%) Query: 260 KAVDTTGAGDSFVGALAFYLA 280 K VDT GAGD+FVG + L+ Sbjct: 329 KIVDTNGAGDAFVGGFLYALS 349 >3LUF-A nrPDB Length = 259 Score = 28.1 bits (61), Expect = 4.9, Method: Compositional matrix adjust. Identities = 21/48 (43%), Positives = 26/48 (54%), Gaps = 2/48 (4%) Query: 189 FYTLSDVFCCNESEAEI-LTGLTVGSAADAGEAALVLLKRGCQVVIIT 235 F TL C E + L LT+ A +GEA VLL+RG VVI+T Sbjct: 35 FDTLEGARHCQGDEYVVALVDLTLPDAP-SGEAVKVLLERGLPVVILT 81 >3JUL-A nrPDB Length = 320 Score = 27.7 bits (60), Expect = 6.6, Method: Compositional matrix adjust. Identities = 19/49 (38%), Positives = 29/49 (59%), Gaps = 2/49 (4%) Query: 232 VIITLGAEGCVVLSQTEPEPKHIPTEKVKAVDTTGAGDSFVGALAFYLA 280 ++++LGA+G + + + IP KV+ + TGAGD FVGA LA Sbjct: 218 LVVSLGAKGSIC-AHNGKLYQVIPP-KVQERNDTGAGDVFVGAFIAGLA 264 >1OXJ-A nrPDB Length = 173 Score = 27.7 bits (60), Expect = 7.2, Method: Compositional matrix adjust. Identities = 17/71 (23%), Positives = 37/71 (52%) Query: 125 AGANLLLNTEDLRAAANVISRAKVMVCQLEITPATSLEALTMARRSGVKTLFNPAPAIAD 184 A L L + L+ AN+++R + + ++ +T++E LT + +K L +P P + Sbjct: 51 ASHKLALCIDKLKERANILNRVEQELLSGQMELSTAVEELTNIVLTPMKPLESPGPPEEN 110 Query: 185 LDPQFYTLSDV 195 + +F + D+ Sbjct: 111 IGLRFLKVIDI 121 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 5C40-A nrPDB 407 e-114 5ZWY-A nrPDB 302 2e-82 4X8F-A nrPDB 293 6e-80 3RY7-A nrPDB 280 4e-76 1VM7-A nrPDB 277 4e-75 1RK2-A nrPDB 276 1e-74 6ILS-A nrPDB 266 8e-72 1TYY-A nrPDB 226 1e-59 3HJ6-A nrPDB 222 1e-58 2C4E-A nrPDB 220 7e-58 6CW5-A nrPDB 220 9e-58 5EYN-A nrPDB 213 1e-55 3KZH-A nrPDB 207 5e-54 2QCV-A nrPDB 203 1e-52 1WYE-A nrPDB 202 2e-52 3H49-A nrPDB 201 4e-52 5KB6-A nrPDB 198 2e-51 2I6B-A nrPDB 198 3e-51 3GBU-A nrPDB 195 2e-50 3I3Y-A nrPDB 194 6e-50 4DU5-A nrPDB 190 8e-49 1V1S-A nrPDB 187 7e-48 3IQ0-A nrPDB 186 1e-47 3UBO-A nrPDB 185 2e-47 3PL2-A nrPDB 183 1e-46 4N08-A nrPDB 181 4e-46 2RBC-A nrPDB 180 6e-46 4LC4-A nrPDB 179 1e-45 3LHX-A nrPDB 178 2e-45 4WJM-A nrPDB 178 3e-45 3LJS-A nrPDB 172 2e-43 2HW1-A nrPDB 170 7e-43 3LOO-A nrPDB 167 6e-42 3GO6-A nrPDB 163 8e-41 2QHP-A nrPDB 161 3e-40 2NWH-A nrPDB 158 5e-39 3N1C-A nrPDB 148 3e-36 2JG5-A nrPDB 103 1e-22 Sequences not found previously or not previously below threshold: 2VAR-A nrPDB 166 1e-41 3NCA-A nrPDB 159 2e-39 2AA0-A nrPDB 127 5e-30 3UQ9-A nrPDB 116 2e-26 2ABQ-A nrPDB 115 3e-26 3KD6-A nrPDB 114 6e-26 3B1N-A nrPDB 113 1e-25 4E84-A nrPDB 111 6e-25 6C9R-A nrPDB 109 2e-24 4E69-A nrPDB 106 1e-23 2AFB-A nrPDB 106 2e-23 3JUL-A nrPDB 101 6e-22 2AWD-A nrPDB 100 7e-22 4GM6-A nrPDB 97 8e-21 3BF5-A nrPDB 96 2e-20 2Q5R-A nrPDB 88 6e-18 2AJR-A nrPDB 84 7e-17 3KTN-A nrPDB 68 4e-12 5YSQ-A nrPDB 61 7e-10 4S1M-A nrPDB 59 4e-09 1YGJ-A nrPDB 56 3e-08 2F7K-A nrPDB 54 1e-07 2I5B-A nrPDB 54 1e-07 4JJP-A nrPDB 53 2e-07 1TD2-A nrPDB 46 2e-05 2DDM-A nrPDB 46 2e-05 3PZS-A nrPDB 45 4e-05 5TQI-A nrPDB 44 8e-05 5B6A-A nrPDB 44 1e-04 1UB0-A nrPDB 43 2e-04 3ZS7-A nrPDB 42 4e-04 3MBJ-A nrPDB 38 0.006 4XF7-A nrPDB 37 0.008 3HYO-A nrPDB 36 0.017 4YL5-A nrPDB 36 0.027 5MEK-A nrPDB 36 0.034 5ZWB-B nrPDB 35 0.044 4I8O-A nrPDB 32 0.29 3CGD-A nrPDB 32 0.38 6CY1-A nrPDB 30 1.2 1J08-A nrPDB 30 1.6 1BJ4-A nrPDB 29 3.8 1OXJ-A nrPDB 28 5.5 4EVZ-A nrPDB 27 9.5 >5C40-A nrPDB Length = 330 Score = 407 bits (1045), Expect = e-114, Method: Composition-based stats. Identities = 322/322 (100%), Positives = 322/322 (100%) Query: 1 MAASGEPQRQWQEEVAAVVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCV 60 MAASGEPQRQWQEEVAAVVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCV Sbjct: 1 MAASGEPQRQWQEEVAAVVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCV 60 Query: 61 QAARLGAMTSMVCKVGKDSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNI 120 QAARLGAMTSMVCKVGKDSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNI Sbjct: 61 QAARLGAMTSMVCKVGKDSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNI 120 Query: 121 IVIVAGANLLLNTEDLRAAANVISRAKVMVCQLEITPATSLEALTMARRSGVKTLFNPAP 180 IVIVAGANLLLNTEDLRAAANVISRAKVMVCQLEITPATSLEALTMARRSGVKTLFNPAP Sbjct: 121 IVIVAGANLLLNTEDLRAAANVISRAKVMVCQLEITPATSLEALTMARRSGVKTLFNPAP 180 Query: 181 AIADLDPQFYTLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLGAEG 240 AIADLDPQFYTLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLGAEG Sbjct: 181 AIADLDPQFYTLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLGAEG 240 Query: 241 CVVLSQTEPEPKHIPTEKVKAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFIAAV 300 CVVLSQTEPEPKHIPTEKVKAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFIAAV Sbjct: 241 CVVLSQTEPEPKHIPTEKVKAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFIAAV 300 Query: 301 SVQAAGTQSSYPYKKDLPLTLF 322 SVQAAGTQSSYPYKKDLPLTLF Sbjct: 301 SVQAAGTQSSYPYKKDLPLTLF 322 >5ZWY-A nrPDB Length = 349 Score = 302 bits (772), Expect = 2e-82, Method: Composition-based stats. Identities = 130/316 (41%), Positives = 179/316 (56%), Gaps = 13/316 (4%) Query: 13 EEVAAVVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCVQAARLGAMTSMV 72 E ++VVGSC D V +P+ GET+H F GFGGKGANQ V A RLGA +MV Sbjct: 33 EYAPDILVVGSCFLDYVGYVDHMPQVGETMHSVSFHKGFGGKGANQAVAAGRLGAKVAMV 92 Query: 73 CKVGKDSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNE-GQNIIVIVAGANLLL 131 VG D G+DYI+ L++N + T + ++T ++TG A I+V+ + N IVI A Sbjct: 93 SMVGTDGDGSDYIKELERNGVDTAYMFRTGKSSTGLAMILVDTKSSNNEIVICPNATNHF 152 Query: 132 NTEDLRAAANVISRA-----KVMVCQLEITPATSLEALTMARRSGVKTLFNPAPAIADLD 186 E LRA N R K ++CQ EI T+L+ + A GV T+FN APA + Sbjct: 153 TPELLRAQTNNYERILHTGLKYLICQNEIPLPTTLDTIKEAHSRGVYTVFNSAPAPKPAE 212 Query: 187 PQ----FYTLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLGAEGCV 242 + F +FC NE EA ++TG+ V A A L + G + V+ITLGA G Sbjct: 213 VEQIKPFLPYVSLFCPNEVEATLITGVKVTDTESAFSAIKALQQLGVRDVVITLGAAG-F 271 Query: 243 VLSQTEPEPKHIPTEKVKAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFIAAVSV 302 VLS+ EP H+ + VKAVDTTGAGD FVG++ ++++ +L + R+N AA+SV Sbjct: 272 VLSENGAEPVHVTGKHVKAVDTTGAGDCFVGSMVYFMSR--GRNLLEACKRANECAAISV 329 Query: 303 QAAGTQSSYPYKKDLP 318 GTQ SYP+ +LP Sbjct: 330 TRKGTQLSYPHPSELP 345 >4X8F-A nrPDB Length = 309 Score = 293 bits (750), Expect = 6e-80, Method: Composition-based stats. Identities = 110/308 (35%), Positives = 160/308 (51%), Gaps = 5/308 (1%) Query: 14 EVAAVVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCVQAARLGAMTSMVC 73 + +VV+GS D V P+ GET+HG + + GGKGANQ V AAR+ A + Sbjct: 3 HMNKLVVLGSVNADHVLQVPSFPRPGETLHGRNYQVIPGGKGANQAVAAARMQADVGFIA 62 Query: 74 KVGKDSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNIIVIVAGANLLLNT 133 VG DSFG + E+ K + I+T + TG A I V++ G+N I I A AN L Sbjct: 63 CVGDDSFGINIRESFKLDGINTAGVKLQPNCPTGIAMIQVSDSGENSICISAEANAKLTA 122 Query: 134 EDLRAAANVISRAKVMVCQLEITPATSLEALTMARRSGVKTLFNPAPAIADLDPQFYTLS 193 + I A+ ++ QLE L+A A+ + + NPAPA +L + Sbjct: 123 AAIEPDLAAIRDARYLLMQLETPLDGILKAAQEAKTAKTNVILNPAPA-RELPDELLKCV 181 Query: 194 DVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLGAEGCVVLSQTEPEPKH 253 D+ NE+EAE+LTG+TV + A +AA L +G ++VIITLG++G + + Sbjct: 182 DLITPNETEAEVLTGITVYDDSSAQQAADALHCKGIEIVIITLGSKGVWLSQN--GRGQR 239 Query: 254 IPTEKVKAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFIAAVSVQAAGTQSSYPY 313 IP VKA DTT AGD+F GAL + LE + ++ AA+SV G Q+S P Sbjct: 240 IPGFVVKATDTTAAGDTFNGALV--TGLLQEMPLESAIKFAHAAAAISVTRFGAQTSIPT 297 Query: 314 KKDLPLTL 321 + ++ L Sbjct: 298 RAEVEAFL 305 >3RY7-A nrPDB Length = 304 Score = 280 bits (717), Expect = 4e-76, Method: Composition-based stats. Identities = 109/302 (36%), Positives = 167/302 (55%), Gaps = 5/302 (1%) Query: 17 AVVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGG-KGANQCVQAARLGAMTSMVCKV 75 VV++GS D R + GET+H + FGG KGANQ + AR+ A T+ + K+ Sbjct: 4 KVVILGSTNVDQFLTVERYAQPGETLHVEEAQKAFGGGKGANQAIATARMQADTTFITKI 63 Query: 76 GKDSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNIIVIVAGANLLLNTED 135 G D + +E+ K I T + +T +A TG A I VN EGQN I + GAN+ + ED Sbjct: 64 GTDGVADFILEDFKVAHIDTSYIIKTAEAKTGQAFITVNAEGQNTIYVYGGANMTMTPED 123 Query: 136 LRAAANVISRAKVMVCQLEITPATSLEALTMARRSGVKTLFNPAPAIADLDPQFYTLSDV 195 + A + I A +V QLE+ + A +A+ GV T+ NPAPA A L + +L D+ Sbjct: 124 VINAKDAIINADFVVAQLEVPIPAIISAFEIAKAHGVTTVLNPAPAKA-LPNELLSLIDI 182 Query: 196 FCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLGAEGCVVLSQTEPEPKHIP 255 NE+EAE+L+G+ V + + A L G + V+ITLG +G ++ + +HI Sbjct: 183 IVPNETEAELLSGIKVTNEQSMKDNANYFLSIGIKTVLITLGKQGTYFATKN--QSQHIE 240 Query: 256 TEKVKAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFIAAVSVQAAGTQSSYPYKK 315 KV A+DTT AGD+F+GA L + +L D ++ N ++++VQ G Q+S P + Sbjct: 241 AYKVNAIDTTAAGDTFIGAFVSRLNKSQD-NLADAIDFGNKASSLTVQKHGAQASIPLLE 299 Query: 316 DL 317 ++ Sbjct: 300 EV 301 >1VM7-A nrPDB Length = 311 Score = 277 bits (709), Expect = 4e-75, Method: Composition-based stats. Identities = 106/305 (34%), Positives = 154/305 (50%), Gaps = 14/305 (4%) Query: 18 VVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCVQAARLGAM-TSMVCKVG 76 + VVGS D+V K GET + + GGKGANQ V A++G V +G Sbjct: 17 ISVVGSSNIDIVLKVDHFTKPGETQKAIEMNVFPGGKGANQAVTVAKIGEKGCRFVTCIG 76 Query: 77 KDSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNIIVIVAGANLLLNTEDL 136 D + + IEN ++ I+ Y TG A I V+ GQN I+I GAN L E + Sbjct: 77 NDDYSDLLIENYEKLGITG---YIRVSLPTGRAFIEVDKTGQNRIIIFPGANAELKKELI 133 Query: 137 RAAANVISRAKVMVCQLEITPATSLEALTMARRSGVKTLFNPAPAIADLDPQFYTLSDVF 196 N +S + +++ Q EI T+LE A+R +F+PAPA ++ + + D Sbjct: 134 D--WNTLSESDILLLQNEIPFETTLEC---AKRFNGIVIFDPAPA-QGINEEIFQYLDYL 187 Query: 197 CCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLGAEGCVVLSQTEPEPKHIPT 256 NE E E L+ G +AA L+ G + VI+ LG +G +++++ E KH PT Sbjct: 188 TPNEKEIEALSKDFFGEFLTVEKAAEKFLELGVKNVIVKLGDKGVLLVNKNEK--KHFPT 245 Query: 257 EKVKAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFIAAVSVQAAGTQSSYPYKKD 316 KVKAVDTT AGD F GA A L+ + E+ + AA+SV G QSS P +++ Sbjct: 246 FKVKAVDTTAAGDVFNGAFAVALS--EGKNPEEAVIFGTAAAAISVTRLGAQSSIPAREE 303 Query: 317 LPLTL 321 + L Sbjct: 304 VEAFL 308 >1RK2-A nrPDB Length = 309 Score = 276 bits (705), Expect = 1e-74, Method: Composition-based stats. Identities = 108/309 (34%), Positives = 164/309 (53%), Gaps = 5/309 (1%) Query: 13 EEVAAVVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCVQAARLGAMTSMV 72 + ++VV+GS D + P GET+ G+ + + FGGKGANQ V A R GA + + Sbjct: 2 QNAGSLVVLGSINADHILNLQSFPTPGETVTGNHYQVAFGGKGANQAVAAGRSGANIAFI 61 Query: 73 CKVGKDSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNIIVIVAGANLLLN 132 G DS G + L ++I K +TG A I VN EG+N+I I AGAN L+ Sbjct: 62 ACTGDDSIGESVRQQLATDNIDITPVSVIKGESTGVALIFVNGEGENVIGIHAGANAALS 121 Query: 133 TEDLRAAANVISRAKVMVCQLEITPATSLEALTMARRSGVKTLFNPAPAIADLDPQFYTL 192 + A I+ A ++ QLE + + A +A ++ NPAPA +L + L Sbjct: 122 PALVEAQRERIANASALLMQLESPLESVMAAAKIAHQNKTIVALNPAPA-RELPDELLAL 180 Query: 193 SDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLGAEGCVVLSQTEPEPK 252 D+ NE+EAE LTG+ V + DA +AA VL ++G + V+ITLG+ G + E + Sbjct: 181 VDIITPNETEAEKLTGIRVENDEDAAKAAQVLHEKGIRTVLITLGSRGVW--ASVNGEGQ 238 Query: 253 HIPTEKVKAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFIAAVSVQAAGTQSSYP 312 +P +V+AVDT AGD+F GAL A L + + ++ AA++V G Q S P Sbjct: 239 RVPGFRVQAVDTIAAGDTFNGAL--ITALLEEKPLPEAIRFAHAAAAIAVTRKGAQPSVP 296 Query: 313 YKKDLPLTL 321 +++++ L Sbjct: 297 WREEIDAFL 305 >6ILS-A nrPDB Length = 313 Score = 266 bits (680), Expect = 8e-72, Method: Composition-based stats. Identities = 89/310 (28%), Positives = 143/310 (46%), Gaps = 5/310 (1%) Query: 15 VAAVVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCVQAARLGAMTSMVCK 74 +VVVGS D+ RLPK GETI GGKGANQ A+L T V + Sbjct: 2 APPLVVVGSANADIYVEIERLPKEGETISAKTGQTLAGGKGANQAACGAKLMYPTYFVGR 61 Query: 75 VGKDSFGNDYIENLKQNDISTEFTYQT--KDAATGTASIIVNNEGQNIIVIVAGANLLLN 132 +G+D+ G E L + Y + TG A +++ ++GQN I+IV GAN+ Sbjct: 62 LGEDAHGKLIAEALGDDGCGVHLDYVRSVNNEPTGHAVVMLQSDGQNSIIIVGGANMKAW 121 Query: 133 TEDL-RAAANVISRAKVMVCQLEITPATSLEALTMARRSGVKTLFNPAPAIADLDPQFYT 191 E + ++ A +++ Q EI + +++ +++GV + + + + Sbjct: 122 PEIMSDDDLEIVRNAGIVLLQREIPDSINIQVAKAVKKAGVPVILDVGGMDTPIPNELLD 181 Query: 192 LSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLGAEGCVVLSQTEPEP 251 D+ NE+E LTG+ + +A K G + V++ LG++G + Q E Sbjct: 182 SIDILSPNETELSRLTGMPTETFEQISQAVAKCHKLGVKQVLVKLGSKGSALFIQGEKPI 241 Query: 252 KHIPTEKVKAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFIAAVSVQAAGTQSSY 311 + + VDTTGAGD+F A F +A S E+ L + A++ VQ G S Sbjct: 242 QQSIIPAAQVVDTTGAGDTFTAA--FAVAMVEGKSHEECLRFAAAAASLCVQVKGAIPSM 299 Query: 312 PYKKDLPLTL 321 P +K + L Sbjct: 300 PDRKSVLKLL 309 >1TYY-A nrPDB Length = 339 Score = 226 bits (575), Expect = 1e-59, Method: Composition-based stats. Identities = 79/331 (23%), Positives = 129/331 (38%), Gaps = 35/331 (10%) Query: 7 PQRQWQEEVAAVVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCVQAARLG 66 P+ + + V V+G DLV + GG AN V ARLG Sbjct: 16 PRGSHMKAMNKVWVIGDASVDLVPEKQN-----------SYLKCPGGASANVGVCVARLG 64 Query: 67 AMTSMVCKVGKDSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNII--VIV 124 + +G D G + + N + F D + + + +G+ ++ Sbjct: 65 GECGFIGCLGDDDAGRFLRQVFQDNGVDVTFLRLDADLTSAVLIVNLTADGERSFTYLVH 124 Query: 125 AGANLLLNTEDLRAAANVISRAKVMVCQLEITPATS--LEALTMARRSGVKTLFNP---- 178 GA+ ++ +DL L PA LE R +G LF+ Sbjct: 125 PGADTYVSPQDL-PPFRQYEWFYFSSIGLTDRPAREACLEGARRMREAGGYVLFDVNLRS 183 Query: 179 -APAIADLDPQFY----TLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVI 233 D P+ L+ + + E L+G A+ +A L GC I Sbjct: 184 KMWGNTDEIPELIARSAALASICKVSADELCQLSG-----ASHWQDARYYLRDLGCDTTI 238 Query: 234 ITLGAEGCVVLSQTEPEPKHIPTEKVKAVDTTGAGDSFVGALAFYLAY---YPNLSLEDM 290 I+LGA+G ++++ H P +V VDTTGAGD+FVG L F L+ + + L + Sbjct: 239 ISLGADGALLITAEGE--FHFPAPRVDVVDTTGAGDAFVGGLLFTLSRANCWDHALLAEA 296 Query: 291 LNRSNFIAAVSVQAAGTQSSYPYKKDLPLTL 321 ++ +N A++V A G ++ P+ L L Sbjct: 297 ISNANACGAMAVTAKGAMTALPFPDQLNTFL 327 >3HJ6-A nrPDB Length = 327 Score = 222 bits (566), Expect = 1e-58, Method: Composition-based stats. Identities = 77/315 (24%), Positives = 129/315 (40%), Gaps = 30/315 (9%) Query: 17 AVVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCVQAARLGAMTSMVCKVG 76 VV +G + D++S ++ FGG AN V +RLG +++ ++G Sbjct: 23 DVVSLGEILVDMISTEE----VNSLSQSREYTRHFGGSPANIAVNLSRLGKKVALISRLG 78 Query: 77 KDSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNIIVIVAGANLLLNTEDL 136 D+FGN ++ LK I T+ Q K+ T + + + + A++ L +D+ Sbjct: 79 ADAFGNYLLDVLKGEQIITDGIQQDKERRTTIVYVSKSTRTPDWLPYRE-ADMYLQEDDI 137 Query: 137 RAAANVISRAKVMVCQLEI-----TPATSLEALTMARRSGVKTLFNP---------APAI 182 +I R+KV I T+++A AR G F+P Sbjct: 138 --IFELIKRSKVFHLSTFILSRKPARDTAIKAFNYAREQGKIVCFDPCYRKVLWPEGDDG 195 Query: 183 ADLDPQFYTLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLGAEGCV 242 A + + + +D + +A L G L+ G + VI+TLG EG Sbjct: 196 AGVVEEIISRADFVKPSLDDARHLFG-----PDSPENYVKRYLELGVKAVILTLGEEG-- 248 Query: 243 VLSQTEPEPKHIPTEKVKAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFIAAVSV 302 V++ E IP AVD TGAGD+F F +++ + N +AA + Sbjct: 249 VIASDGEEIIRIPAFSEDAVDVTGAGDAFWS--GFICGLLDGYTVKRSIKLGNGVAAFKI 306 Query: 303 QAAGTQSSYPYKKDL 317 + G S P K+D+ Sbjct: 307 RGVGALSPVPSKEDI 321 >2C4E-A nrPDB Length = 302 Score = 220 bits (560), Expect = 7e-58, Method: Composition-based stats. Identities = 68/308 (22%), Positives = 115/308 (37%), Gaps = 30/308 (9%) Query: 14 EVAAVVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCVQAARLGAMTSMVC 73 ++ + VG D + + P+ +I +GG AN V +LG + ++ Sbjct: 4 KMEKITCVGHTALDYIFNVEKFPEPNTSIQIPSARKYYGGAAANTAVGIKKLGVNSELLS 63 Query: 74 KVGKDSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNIIVIVAGANLL--- 130 VG D + Y LK DI+ Y +++ T A I + + I + GA Sbjct: 64 CVGYDFKNSGYERYLKNLDINISKLYYSEEEETPKAWIFTDKDNNQITFFLWGAAKHYKE 123 Query: 131 LNTEDLRAAANVISRAKVMVCQLEITPATSLEALTMARRSGVKTLFNPAPAIADLDPQFY 190 LN + I+ P +L+ A + + F+P + + Sbjct: 124 LNPPNFNTEIVHIATGD---------PEFNLKCAKKAYGNNL-VSFDPGQDLPQYSKEML 173 Query: 191 ----TLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLGAEGCVVLSQ 246 ++ N+ E E + L D E +I+T G++G V+ ++ Sbjct: 174 LEIIEHTNFLFMNKHEFERASNLLNFEIDDYLE--------RVDALIVTKGSKGSVIYTK 225 Query: 247 TEPEPKHIPTEKV-KAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFIAAVSVQAA 305 + IP K K +D TGAGDS+ F AY LE A+ V+A Sbjct: 226 DKK--IEIPCIKAGKVIDPTGAGDSYRA--GFLSAYVKGYDLEKCGLIGAATASFVVEAK 281 Query: 306 GTQSSYPY 313 G Q++ P Sbjct: 282 GCQTNLPT 289 >6CW5-A nrPDB Length = 332 Score = 220 bits (559), Expect = 9e-58, Method: Composition-based stats. Identities = 91/317 (28%), Positives = 133/317 (41%), Gaps = 31/317 (9%) Query: 19 VVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCVQAARLGAMTSMVCKVGKD 78 +V GS D + + GETI GGKGANQ AR G + +G D Sbjct: 16 LVRGSVNIDEFFHLPHIVRPGETISSTGLTKRAGGKGANQAFAVARAGGQVELDGAIGDD 75 Query: 79 SFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNIIVIVAGANLLLNTEDLRA 138 G E L+ + T+ KD TG A I +G+N IV+ AGAN L + Sbjct: 76 --GIWVKEMLESAGVGTDKLKIVKDEVTGRAVIQSAADGENSIVLHAGANYYLPSPTPTT 133 Query: 139 AANVISRAKVMVCQLEITPATSLEALTMARRSG--VKTLFNPAPAI--ADLDPQFYTLSD 194 + + ++ Q E+ +++L LT A +S + ++FNP+P + A L + Sbjct: 134 SLATYTH---LLVQNEVPLSSTLAYLTAAGQSSPPLTSVFNPSPMLTPAQLREFPWKHLS 190 Query: 195 VFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQV----------------VIITLGA 238 NE E L L GS+A+ GEA L+ +I TLGA Sbjct: 191 WLIVNEGELGDLL-LAFGSSANPGEAKEDELQAKASAGILELHENDYFSKNVGIICTLGA 249 Query: 239 EGCVVLSQTEPEPKHIPTEKVK--AVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNF 296 +G ++ + E ++P K++ DTTGAGD F G F SL+D L Sbjct: 250 KG-ILCYEPGKEVGYLPAAKLQNPVKDTTGAGDCFAGY--FVAGLMSGKSLQDALKTCLV 306 Query: 297 IAAVSVQAAGTQSSYPY 313 + V+ G S P Sbjct: 307 ACGICVENEGAMESVPT 323 >5EYN-A nrPDB Length = 323 Score = 213 bits (541), Expect = 1e-55, Method: Composition-based stats. Identities = 67/324 (20%), Positives = 129/324 (39%), Gaps = 40/324 (12%) Query: 13 EEVAAVVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCVQAARLGAMTSMV 72 + ++ V + G + DL+ H + GG AN V ARL ++ Sbjct: 16 DSMSRVWLTGDAVVDLI--------PDGQQH---YLKCPGGAPANVAVAIARLSGRSAFF 64 Query: 73 CKVGKDSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQN--IIVIVAGANLL 130 +VG D FG + L + + + T T + ++ G+ ++ A+ Sbjct: 65 GRVGNDPFGRFMQQTLTDEQVDCQHLHFDPVHRTSTVVVDLDEHGERSFTFMVKPSADQF 124 Query: 131 LNTEDLRAAANVISRAKVMVCQLEI----TPATSLEALTMARRSGVKTLFNP--APAIAD 184 L D+ + + VC + + + +++ A+ + G F+P + Sbjct: 125 LQLSDI---PSFQKGEWLHVCSIALANQPSRSSTFAAIAQMKEVGGYVSFDPNLREEVWS 181 Query: 185 LDPQF-------YTLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLG 237 + L+DV +E E + LTG E + +V++TLG Sbjct: 182 EPQELQATVMRAVGLADVVKFSEEELQFLTGT-----QSIEEGLQAIADFQIPLVVVTLG 236 Query: 238 AEGCVVLSQTEPEPKHIPTEKVKAVDTTGAGDSFVGALAFYLAYYPN----LSLEDMLNR 293 A+G +V + + + + VK +DTTGAGD+FVG L + L+ + ++ D + Sbjct: 237 AKGALVATPNSQQI--VSGKAVKPIDTTGAGDAFVGGLLYRLSVAQDWHNQATILDAVKW 294 Query: 294 SNFIAAVSVQAAGTQSSYPYKKDL 317 +N A++ G ++ P + L Sbjct: 295 ANGCGALATTQKGAMTALPNQAAL 318 >3KZH-A nrPDB Length = 328 Score = 207 bits (527), Expect = 5e-54, Method: Composition-based stats. Identities = 67/301 (22%), Positives = 126/301 (41%), Gaps = 17/301 (5%) Query: 13 EEVAAVVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCVQAARLGAMTSMV 72 + ++V G+ + D+ + + + GH I FGG N AR+G T+ + Sbjct: 4 RKEPYLLVFGASVVDVFGFSKASYRPYNSTPGH-VKISFGGVCRNIAENMARVGVNTNFM 62 Query: 73 CKVGKDSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNIIVIVAGANL-LL 131 +G D G +E+ K+ + + + +T T I++ G+ + I ++ + Sbjct: 63 SILGNDEHGKSIVEHSKKIGYHMDDSMVIEGGSTPTYLAILDENGEMVSAIADMKSIGAM 122 Query: 132 NTEDLRAAANVISRAKVMVCQLEITPATSLEALTMARRSGVKTLFNPAPA-----IADLD 186 NT+ + + + A+ V L+ +E L + + +P A + L Sbjct: 123 NTDFIDSKREIFENAEYTV--LDSDNPEIMEYLLKNFKDKTNFILDPVSAEKASWVKHLI 180 Query: 187 PQFYTLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLGAEGCVVLSQ 246 F+T N EAEIL G + D +A+ L G + V I+L A+G + Sbjct: 181 KDFHT----IKPNRHEAEILAGFPITDTDDLIKASNYFLGLGIKKVFISLDADG--IFYN 234 Query: 247 TEPEPKHIPTEKVKAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFIAAVSVQAAG 306 I +V + TGAGDSFV L + Y + +ED++ + ++ +++ Sbjct: 235 DGVSCGKIKATEVDVKNVTGAGDSFVAGLGY--GYMNKMPIEDIVKFAMTMSNITISHEE 292 Query: 307 T 307 T Sbjct: 293 T 293 >2QCV-A nrPDB Length = 332 Score = 203 bits (515), Expect = 1e-52, Method: Composition-based stats. Identities = 69/322 (21%), Positives = 127/322 (39%), Gaps = 28/322 (8%) Query: 17 AVVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCVQAARLGAMTSMVCKVG 76 ++ +G DL ++ P ET+ F GG AN + +++LG + K+ Sbjct: 13 DLIAIGRACIDLNAVEYNRPME-ETM---TFSKYVGGSPANIVIGSSKLGLKAGFIGKIA 68 Query: 77 KDSFGNDYIENLKQNDISTEFTYQTKDAA-TGTAS--IIVNNEGQNIIVIVAGANLLLNT 133 D G ++ + T ++ TG A I E ++ A+L L+ Sbjct: 69 DDQHGRFIESYMRGVGVDTSNLVVDQEGHKTGLAFTEIKSPEECSILMYRQDVADLYLSP 128 Query: 134 EDLRAAANVISRAKVMVCQL-----EITPATSLEALTMARRSGVKTLF--NPAPAIADLD 186 E++ A I R+K+++ + L+A+ +A+R+ VK +F + P + Sbjct: 129 EEVNEA--YIRRSKLLLVSGTALSKSPSREAVLKAIRLAKRNDVKVVFELDYRPYSWETP 186 Query: 187 PQ-------FYTLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLGAE 239 + SD+ E ++L T D E L K ++++I G E Sbjct: 187 EETAVYYSLVAEQSDIVIGTREEFDVLENRT--EKGDNDETIRYLFKHSPELIVIKHGVE 244 Query: 240 GCVVLSQTEPEPKHIPTEKVKAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFIAA 299 G ++ E K K + T GAGDS+ A AF A +E L + A+ Sbjct: 245 GSFAYTKAG-EAYRGYAYKTKVLKTFGAGDSY--ASAFLYALISGKGIETALKYGSASAS 301 Query: 300 VSVQAAGTQSSYPYKKDLPLTL 321 + V + + P +++ + Sbjct: 302 IVVSKHSSSDAMPSVEEIEALI 323 >1WYE-A nrPDB Length = 311 Score = 202 bits (514), Expect = 2e-52, Method: Composition-based stats. Identities = 66/321 (20%), Positives = 124/321 (38%), Gaps = 29/321 (9%) Query: 15 VAAVVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCVQAARLGAMTSMVCK 74 +A ++ +G + + +L+ G H F G AN CV + G ++ K Sbjct: 1 MAKLITLGEILIEFNALS-----PGPLRHVSYFEKHVAGSEANYCVAFIKQGNECGIIAK 55 Query: 75 VGKDSFGNDYIENLKQNDISTEFTYQTKDAATGTASII----VNNEGQNIIVIVAGANLL 130 VG D FG + IE L+ + A TG I V + ++I A Sbjct: 56 VGDDEFGYNAIEWLRGQGVDVSHMKIDPSAPTGIFFIQRHYPVPLKSESIYYRKGSAGSK 115 Query: 131 LNTEDLRA----AANVISRAKVMVCQLEITPATSLEALTMARRSGVKT-----LFNPAPA 181 L+ ED+ +A+++ + + + +A +A T L++ A Sbjct: 116 LSPEDVDEEYVKSADLVHSSGITLAISSTAKEAVYKAFEIASNRSFDTNIRLKLWSAEEA 175 Query: 182 IADLDPQFYT-LSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLGAEG 240 ++ + +++I+ G +D +AA +++++ LG +G Sbjct: 176 KREILKLLSKFHLKFLITDTDDSKIILGE-----SDPDKAAKAFSDY-AEIIVMKLGPKG 229 Query: 241 CVVLSQTEPEPKHIPTEKVKAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFIAAV 300 +V + + +V D TGAGD+ G F YY +E L+ + + + Sbjct: 230 AIVYYDGKK--YYSSGYQVPVEDVTGAGDALGGT--FLSLYYKGFEMEKALDYAIVASTL 285 Query: 301 SVQAAGTQSSYPYKKDLPLTL 321 +V G Q + P KD+ L Sbjct: 286 NVMIRGDQENLPTTKDIETFL 306 >3H49-A nrPDB Length = 325 Score = 201 bits (511), Expect = 4e-52, Method: Composition-based stats. Identities = 72/323 (22%), Positives = 135/323 (41%), Gaps = 35/323 (10%) Query: 17 AVVVVGSCMTDL--------VSLTSRLPKTGETIHGHKFFIGFGGKGANQCVQAARLGAM 68 V+ +G+ + D+ + P + + GG N+ +RLG Sbjct: 7 DVICIGAAIVDIPLQPVSKNIFDVDSYPLE-------RIAMTTGGDAINEATIISRLGHR 59 Query: 69 TSMVCKVGKDSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNIIVIVAGAN 128 T+++ ++GKD+ G +++ ++ +I + Q T +V +G+ V + Sbjct: 60 TALMSRIGKDAAGQFILDHCRKENIDIQSLKQDVSIDTSINVGLVTEDGERTFVTNRNGS 119 Query: 129 LL-LNTEDLRAAANVISRAKVM-VCQLEITPATSLEALT-MARRSGVKTLFNPAPAIADL 185 L LN +D+ A S+AK++ + + +P +ALT + ++ + + A I Sbjct: 120 LWKLNIDDVDFAR--FSQAKLLSLASIFNSPLLDGKALTEIFTQAKARQMIICADMIKPR 177 Query: 186 DP-------QFYTLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLGA 238 + + D N +EA++LTG E A L G + V+I G Sbjct: 178 LNETLDDICEALSYVDYLFPNFAEAKLLTGKET-----LDEIADCFLACGVKTVVIKTGK 232 Query: 239 EGCVVLSQTEPEPKHIPTEKVKAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFIA 298 +GC + + + K + A+DT GAGD+F A F A +L + +N A Sbjct: 233 DGCFI-KRGDMTMKVPAVAGITAIDTIGAGDNF--ASGFIAALLEGKNLRECARFANATA 289 Query: 299 AVSVQAAGTQSSYPYKKDLPLTL 321 A+SV + G + +K + L Sbjct: 290 AISVLSVGATTGVKNRKLVEQLL 312 >5KB6-A nrPDB Length = 363 Score = 198 bits (504), Expect = 2e-51, Method: Composition-based stats. Identities = 70/365 (19%), Positives = 136/365 (37%), Gaps = 53/365 (14%) Query: 1 MAASGEPQ-RQWQEEVAAVVV------VGSCMTDLVSLTSRL------PKTG-------- 39 MAA+ EP+ ++ + E + +G+ + D+ ++ + K Sbjct: 3 MAAADEPKPKKLKVEAPQALSENVLFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAEDK 62 Query: 40 ------ETIHGHKFFIGFGGKGAN---QCVQAARLGAMTS-MVCKVGKDSFGNDYIENLK 89 E + K GG N + + +G D FG Sbjct: 63 HKELFDELVKKFKVEYHAGGSTQNSMKVAQWLIQEPHKAATFFGCIGIDKFGEILKRKAA 122 Query: 90 QNDISTEFTYQTKDAATGTASIIVNNEGQNIIVIVAGANLLLNTEDLRAAANV--ISRAK 147 + + Y+ + TGT + + ++++ +A AN + L N + +A+ Sbjct: 123 DAHVDAHY-YEQNEQPTGTCAACITGGNRSLVANLAAANCYKKEKHLDLERNWVLVEKAR 181 Query: 148 VMVCQ---LEITPATSLEALTMARRSG-VKTLFNPAPAIADLDPQFY----TLSDVFCCN 199 V L ++P + L+ A + V TL AP I+ + D+ N Sbjct: 182 VYYIAGFFLTVSPESVLKVARYAAENNRVFTLNLSAPFISQFFKEALMDVMPYVDILFGN 241 Query: 200 ESEAEILT---GLTVGSAADAGEAALVLLK---RGCQVVIITLGAEGCVVLSQTEPEPKH 253 E+EA G + + A L K + + VI T G + +V ++ + Sbjct: 242 ETEAATFAREQGFETKDIKEIAKKAQALPKVNSKRQRTVIFTQGRDDTIVAAENDVTAFP 301 Query: 254 IPTE-KVKAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFIAAVSVQAAGTQSSYP 312 + + + + +DT GAGD+FVG F + L + + ++ A+V ++ G ++P Sbjct: 302 VLDQNQEEIIDTNGAGDAFVG--GFLSQLVSDKPLTECIRAGHYAASVIIRRTGC--TFP 357 Query: 313 YKKDL 317 K D Sbjct: 358 EKPDF 362 >2I6B-A nrPDB Length = 345 Score = 198 bits (503), Expect = 3e-51, Method: Composition-based stats. Identities = 62/314 (19%), Positives = 120/314 (38%), Gaps = 29/314 (9%) Query: 27 DLVSLTSRLPKT-GETIHGHKFFIGFGGKGANQCVQAARLGAM-----TSMVCKVGKDSF 80 D + + + E + K GG N ++ A+ + +G D F Sbjct: 37 DQILAEDKHKELFDELVKKFKVEYHAGGSTQN-SIKVAQWMIQQPHKAATFFGCIGIDKF 95 Query: 81 GNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNIIVIVAGANLLLNTEDLRAAA 140 G + + + Y+ + TGT + + + +++I +A AN + L Sbjct: 96 GEILKRKAAEAHVDAHY-YEQNEQPTGTCAACITGDNRSLIANLAAANCYKKEKHLDLEK 154 Query: 141 NVISRAKVMVCQ-----LEITPATSLEALTMARRSGVKTLFN-PAPAIADLDPQ----FY 190 N + K VC L ++P + L+ A + N AP I+ + Sbjct: 155 NWMLVEKARVCYIAGFFLTVSPESVLKVAHHASENNRIFTLNLSAPFISQFYKESLMKVM 214 Query: 191 TLSDVFCCNESEAEILT---GLTVGSAADAGEAALVLLK---RGCQVVIITLGAEGCVVL 244 D+ NE+EA G + + L K + ++VI T G + ++ Sbjct: 215 PYVDILFGNETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMA 274 Query: 245 SQTEPEPKHIPTEKVK-AVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFIAAVSVQ 303 +++E + + K +DT GAGD+FVG F + L + + ++ A++ ++ Sbjct: 275 TESEVTAFAVLDQDQKEIIDTNGAGDAFVG--GFLSQLVSDKPLTECIRAGHYAASIIIR 332 Query: 304 AAGTQSSYPYKKDL 317 G ++P K D Sbjct: 333 RTGC--TFPEKPDF 344 >3GBU-A nrPDB Length = 313 Score = 195 bits (496), Expect = 2e-50, Method: Composition-based stats. Identities = 71/316 (22%), Positives = 126/316 (39%), Gaps = 35/316 (11%) Query: 15 VAAVVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCVQAARLGAMTSMVCK 74 ++ + +G + DL+S+ K F GG AN V +RLG +S++ K Sbjct: 1 MSLIASIGELLIDLISVEEGDLKDVRL-----FEKHPGGAPANVAVGVSRLGVKSSLISK 55 Query: 75 VGKDSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNIIVIVAGA--NLLLN 132 VG D FG IE L + ++ T + + TG + + + ++ A N+ LN Sbjct: 56 VGNDPFGEYLIEELSKENVDTRGIVKDEKKHTGIVFVQLKGASPSFLLYDDVAYFNMTLN 115 Query: 133 TEDLRAAANV-ISRAKVMVCQLEITPATSLEALTMARRSGVKTLFNP----------APA 181 + I ++ + T ++ + + S + F+ Sbjct: 116 DINWDIVEEAKIVNFGSVILARNPSRETVMKVIKKIKGSSLIA-FDVNLRLDLWRGQEEE 174 Query: 182 IADLDPQFYTLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLGAEGC 241 + + + L+D+ +E E L V +G + ITLG +G Sbjct: 175 MIKVLEESIKLADIVKASEEEVLYLENQGVE-------------VKGSMLTAITLGPKGF 221 Query: 242 VVLSQTEPEPKHIPTEKVKAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFIAAVS 301 ++ +P+ V +DTTGAGD+F+ AL + L L + +N +AA+S Sbjct: 222 RLIKN--ETVVDVPSYNVNPLDTTGAGDAFMAALLVGILKLKGLDLLKLGKFANLVAALS 279 Query: 302 VQAAGTQSSYPYKKDL 317 Q G S+ P K +L Sbjct: 280 TQKRGAWST-PRKDEL 294 >3I3Y-A nrPDB Length = 299 Score = 194 bits (492), Expect = 6e-50, Method: Composition-based stats. Identities = 82/306 (26%), Positives = 134/306 (43%), Gaps = 24/306 (7%) Query: 17 AVVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCVQAARLGAMTSMVCKVG 76 V V G+ D +PK G +IHG K GGKGANQ + +R G T ++ G Sbjct: 4 RVYVTGNITVDETWSIPDIPKKGASIHGVKVSQDIGGKGANQAIILSRCGIETRLIAATG 63 Query: 77 KDSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQN-IIVIVAGANLLLNTED 135 DS G + +K + + + T+ I+ + +G N II A A+ E Sbjct: 64 NDSNGAWIRQQIKNEPL-MLLPDGHFNQHSDTSIILNSADGDNAIITTTAAADTFSLDEM 122 Query: 136 LRAAANVISRAKVMVCQLEITPATSLEALTMARRSGVKTLFNPAPAIADLDPQFYTLSDV 195 + A+ ++ +++ Q + + AR G+ T+FNP+P D + L D+ Sbjct: 123 IPHMADAVA-GDILLQQGNFSLDKTRALFQYARSRGMTTVFNPSPVNPDFCH-LWPLIDI 180 Query: 196 FCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLGAEGCVVLSQTEPEPKHIP 255 NESEAE+L G + ++IT GA G ++ E + + P Sbjct: 181 AVVNESEAELLQP------------------YGVKTLVITQGAAGAWLVQ--EGQRQFCP 220 Query: 256 TEKVKAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFIAAVSVQAAGTQSSYPYKK 315 +A+DTTGAGD+F+ + L ++ AA++V GT S++P + Sbjct: 221 AVPAEALDTTGAGDTFLAVMLASALLRGVAPDALALAHASRAAAITVSRRGTLSAFPGSR 280 Query: 316 DLPLTL 321 +L L Sbjct: 281 ELAALL 286 >4DU5-A nrPDB Length = 336 Score = 190 bits (482), Expect = 8e-49, Method: Composition-based stats. Identities = 71/325 (21%), Positives = 107/325 (32%), Gaps = 31/325 (9%) Query: 10 QWQEEVAAVVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCVQAARLGAMT 69 Q V+ G M LV+ + G H F G N + ARLG Sbjct: 21 QSMTSALDVITFGEAMMLLVA-----DRPGPLEHAEAFHKRTAGAETNVAIGLARLGLKV 75 Query: 70 SMVCKVGKDSFGNDYIENLKQNDISTEFTYQTKDAATGTAS---IIVNNEGQNIIVIVAG 126 ++G DS G + + I TG + ++ Sbjct: 76 GWASRLGTDSMGRYLLAAMAAEGIDCSHVVCDATQKTGFQFKGKVTDGSDPPVEYHRKGS 135 Query: 127 ANLLLNTEDLRAAANVISRAKVMVCQLEITPATSLEALT----MARRSGVKTLFNP---- 178 A + D+ A + +R AT+L A + R +G F+P Sbjct: 136 AASHMGVADIDEAWLLSARHLHATGVFPAISATTLPAARKTMDLMRAAGRSVSFDPNLRP 195 Query: 179 -----APAIADLDPQFYTLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVI 233 + D T +D E LTG T A + G ++V+ Sbjct: 196 TLWATPELMRDAINDLATRADWVLPGMEEGRFLTGETTPEG-----VARFYRQLGAKLVV 250 Query: 234 ITLGAEGCVVLSQTEPEPKHIPTEKV-KAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLN 292 + LGAEG E + V + VDT GAGD F A+ A L + + + Sbjct: 251 VKLGAEGAYF--DGEAGSGRVAGFPVAEVVDTVGAGDGF--AVGVISALLDGLGVPEAVK 306 Query: 293 RSNFIAAVSVQAAGTQSSYPYKKDL 317 R +I A +VQ G P + +L Sbjct: 307 RGAWIGARAVQVLGDSEGLPTRAEL 331 >1V1S-A nrPDB Length = 309 Score = 187 bits (474), Expect = 7e-48, Method: Composition-based stats. Identities = 68/325 (20%), Positives = 108/325 (33%), Gaps = 42/325 (12%) Query: 15 VAAVVVVGSCMTDLVSLTSRLPKTGETIHGHKF-FIGFGGKGANQCVQAARLGAMTSMVC 73 + VV G + LV P+ + G + + GG N V ARLG V Sbjct: 1 MLEVVTAGEPLVALV------PQEPGHLRGKRLLEVYVGGAEVNVAVALARLGVKVGFVG 54 Query: 74 KVGKDSFGNDYIENLKQNDISTEF---------TYQTKDAATGTASIIVNNEGQNIIVIV 124 +VG+D G E L+ + Y + G + +G + Sbjct: 55 RVGEDELGAMVEERLRAEGVDLTHFRRAPGFTGLYLREYLPLGQGRVFYYRKGSAGSALA 114 Query: 125 AGANLLLNTEDLRAAANVISRAKVMVCQLEITPATSLEALTMARRSGVKTLFN------- 177 GA D + + + A SL A+ A+R GV+ + Sbjct: 115 PGAF----DPDYLEGVRFLHLSGITPALSPEARAFSLWAMEEAKRRGVRVSLDVNYRQTL 170 Query: 178 -PAPAIADLDPQFYTLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITL 236 + D+ +E EAE+L G L V++ Sbjct: 171 WSPEEARGFLERALPGVDLLFLSEEEAELLFG----------RVEEALRALSAPEVVLKR 220 Query: 237 GAEGCVVLSQTEPEPKHIPTEKVKAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNF 296 GA+G + V+AVD GAGD+F + L +E+ L +N Sbjct: 221 GAKGAWAF--VDGRRVEGSAFAVEAVDPVGAGDAFAA--GYLAGAVWGLPVEERLRLANL 276 Query: 297 IAAVSVQAAGTQSSYPYKKDLPLTL 321 + A + G PY++DL + L Sbjct: 277 LGASVAASRGDHEGAPYREDLEVLL 301 >3IQ0-A nrPDB Length = 330 Score = 186 bits (471), Expect = 1e-47, Method: Composition-based stats. Identities = 66/321 (20%), Positives = 115/321 (35%), Gaps = 27/321 (8%) Query: 15 VAAVVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCVQAARLGAMTSMVCK 74 ++ V +G + ++++ P I + G A Q RLG ++ Sbjct: 3 LSKVFTIGEILVEIMASKIGQPFDQPGIWNGPY---PSGAPAIFIDQVTRLGVPCGIISC 59 Query: 75 VGKDSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQN--IIVIVAGANLLLN 132 VG D FG+ I L + + ATG+A + +N G I I A L+ Sbjct: 60 VGNDGFGDINIHRLAADGVDIRGISVLPLEATGSAFVTYHNSGDRDFIFNIKNAACGKLS 119 Query: 133 TEDLRA----AANVISRAKVMVCQLEITPATSLEALTMARRSGVKTLFNP--------AP 180 + + + + A +A+T+ + +G F+P P Sbjct: 120 AQHVDENILKDCTHFHIMGSSLFSFHMVDA-VKKAVTIVKANGGVISFDPNIRKEMLDIP 178 Query: 181 AIADLDPQFYTLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLGAEG 240 + D L+D++ +E E +L+ + A L+ G + VI+ G +G Sbjct: 179 EMRDALHFVLELTDIYMPSEGEVLLLSPHSTPE-----RAIAGFLEEGVKEVIVKRGNQG 233 Query: 241 CVVLSQTEPEPKHIPTEKVKAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFIAAV 300 S E H+ + V+ VD TGAGD F GA L +N A+ Sbjct: 234 ASYYSANEQ--FHVESYPVEEVDPTGAGDCFGGAWIACRQL--GFDAHRALQYANACGAL 289 Query: 301 SVQAAGTQSSYPYKKDLPLTL 321 +V G ++ + Sbjct: 290 AVTRRGPMEGTSRLMEIETFI 310 >3UBO-A nrPDB Length = 354 Score = 185 bits (469), Expect = 2e-47, Method: Composition-based stats. Identities = 69/323 (21%), Positives = 118/323 (36%), Gaps = 41/323 (12%) Query: 17 AVVVVGSCMTDLVSLTSR-LPKTGETIHGH-----------------KFFIGFGGKGANQ 58 V+ +G+ + D+++ + I G GG N Sbjct: 7 DVLTIGNAIVDIIARCDDSFLEENGIIKGAMNLINADRAELLYSRMGPAVEASGGSAGNT 66 Query: 59 CVQAARLGAMTSMVCKVGKDSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQ 118 A LG + KV D G + +++ + + T + I V +G+ Sbjct: 67 AAGVASLGGRAAYFGKVADDQLGEIFTHDIRAQGVHFQTKPLDGHPPTARSMIFVTEDGE 126 Query: 119 NIIVIVAGANLLLNTEDLRAAANVISRAKVMVCQLE-ITPATS----LEALTMARRSGVK 173 + GA + L ED+ +V++++KV + P + EA +A G + Sbjct: 127 RSMNTYLGACVELGPEDVED--DVVAQSKVTYFEGYLWDPPRAKDAIREAARIAHAHGRE 184 Query: 174 TLFNPAPA--IADLDPQFYTL-----SDVFCCNESEAEILTGLTVGSAADAGEAALVLLK 226 T + + + +F L D+ N EA L + + AL LL Sbjct: 185 TAMTLSDSFCVHRYRSEFLELMRSGTVDIVFANRQEALALY------ETEDFDRALELLA 238 Query: 227 RGCQVVIITLGAEGCVVLSQTEPEPKHIPTEKVKAVDTTGAGDSFVGALAFYLAYYPNLS 286 R C++ +TL EG VV+ E + + + VDTTGAGD + F Y S Sbjct: 239 RDCKLAAVTLSEEGSVVVRGAE-RVRVGASVLEQVVDTTGAGDLYAA--GFLFGYTSGRS 295 Query: 287 LEDMLNRSNFIAAVSVQAAGTQS 309 LE+ N A + + G + Sbjct: 296 LEECSKLGNLAAGIVIGQIGPRP 318 >3PL2-A nrPDB Length = 319 Score = 183 bits (463), Expect = 1e-46, Method: Composition-based stats. Identities = 76/321 (23%), Positives = 126/321 (39%), Gaps = 31/321 (9%) Query: 17 AVVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCVQAARLGAMTSMVCKVG 76 V+ +G D+ L S + F GG AN V AAR G ++++ +VG Sbjct: 10 EVLAIGRLGVDIYPLQSGV----GLADVQSFGKYLGGSAANVSVAAARHGHNSALLSRVG 65 Query: 77 KDSFGNDYIENLKQNDISTEF--TYQTKDAATGTASIIVNNEGQNIIVIVAGANLLLNTE 134 D FG + L++ + ++ T QT I ++ A LN E Sbjct: 66 NDPFGEYLLAELERLGVDNQYVATDQTFKTPVTFCEIFPPDDFPLYFYREPKAPD-LNIE 124 Query: 135 DLRAAANVISRAKVMVCQL-----EITPATSLEALTMARRSGVKTLF--NPAPAIADLDP 187 + + + A ++ L E + T E LT R + T+F + P + Sbjct: 125 SADVSLDDVREADILWFTLTGFSEEPSRGTHREILT-TRANRRHTIFDLDYRPMFWESPE 183 Query: 188 Q-------FYTLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLGAEG 240 + S V N+ E EI G T + A LL+RG ++ I+ G +G Sbjct: 184 EATKQAEWALQHSTVAVGNKEECEIAVGET-----EPERAGRALLERGVELAIVKQGPKG 238 Query: 241 CVVLSQTEPEPKHIPTEKVKAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFIAAV 300 V++ T+ E +P V ++ GAGD+F GAL LE +L +N A+ Sbjct: 239 --VMAMTKDETVEVPPFFVDVINGLGAGDAFGGALCH--GLLSEWPLEKVLRFANTAGAL 294 Query: 301 SVQAAGTQSSYPYKKDLPLTL 321 ++ P ++ +L Sbjct: 295 VASRLECSTAMPTTDEVEASL 315 >4N08-A nrPDB Length = 348 Score = 181 bits (458), Expect = 4e-46, Method: Composition-based stats. Identities = 62/295 (21%), Positives = 111/295 (37%), Gaps = 28/295 (9%) Query: 45 HKFFIGFGGKGANQC-----VQAARLGAMTSMVCKVGKDSFGNDYIENLKQNDISTEFTY 99 GG G N +Q A G + V + D +G E + I + Sbjct: 58 PNVRYVPGGSGLNVARVAQWMQQAYKGKFVTYVGCIADDRYGKVLKEAAEHEGIVMAVEH 117 Query: 100 QTKDAATGTASIIVNNEGQNIIVIVAGANLLLNTEDLRAAA--NVISRAKVMVCQ---LE 154 TK A +G ++ + + + ++ + AN L++E +R+ A + +++ L Sbjct: 118 TTK-AGSGACAVCITGKERTLVADLGAAN-HLSSEHMRSPAVVRAMDESRIFYFSGFTLT 175 Query: 155 ITPATSLEALTMARR-SGVKTLFNPAPAIADLDP----QFYTLSDVFCCNESEAEILTGL 209 + L+A AR G+ + AP I + +D+ N EA+ + Sbjct: 176 VDVNHVLQACRKAREVDGLFMINLSAPFIMQFFSAQLGEVLPYTDIIVANRHEAKEFANM 235 Query: 210 T------VGSAADAGEAALVLLKRGCQVVIITLGAEGCVVLSQTEPEPKHIPT-EKVKAV 262 V A + + +VV+ T E V+ ++ E +P ++ K + Sbjct: 236 MKWDTDCVEEIARRAVSEVPYTGTKGRVVVFTRDIESTVLATKDGVETVPVPQLDQDKVI 295 Query: 263 DTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFIAAVSVQAAGTQSSYPYKKDL 317 D GAGD+F+G F AY L ++ A +Q G S+P K Sbjct: 296 DMNGAGDAFMG--GFLSAYAVGKDLRRCCETGHYTAQEVIQRDGC--SFPEKPSF 346 >2RBC-A nrPDB Length = 343 Score = 180 bits (457), Expect = 6e-46, Method: Composition-based stats. Identities = 69/304 (22%), Positives = 119/304 (39%), Gaps = 11/304 (3%) Query: 16 AAVVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCVQAARLGAMTSMVCKV 75 V+ VG+ + D + + +PK + ++ G ++ R+G S+ V Sbjct: 30 KHVLCVGAAVLDTLFRVADMPKGEGKVLPYEVLQIAEGMASSAAYAVHRMGGRASLWGAV 89 Query: 76 GKDSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNIIVIVAGANLLLNTED 135 G D G + +L ++ I T A + ++II++N G+ +IV L + Sbjct: 90 GDDETGTRILRDLSESGIDTSGMTVAPGARSALSTIIIDNRGERLIVPFYDHRLH--EKK 147 Query: 136 LRAAANVISRAKVMVCQLEITPATSLEALTMARRSGVKTLFNPAPAIADLDPQFYTLSDV 195 I+ ++ + P +L+ LT+AR G + + A + + Sbjct: 148 RACTPEDIALFDAVLVDVRW-PELALDVLTVARALGKPAILDGDVAPVETLEGLAPAATH 206 Query: 196 FCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVI-ITLGAEGCVVLSQTEPEPKHI 254 +E A LTGL + VL R Q I +T G GC +P Sbjct: 207 IVFSEPAATRLTGLET-----VKDMLPVLHARYPQTFIAVTAGPAGCWWTEADDPTVHFQ 261 Query: 255 PTEKVKAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFIAAVSVQAAGTQSSYPYK 314 T +V+AVDT AGD F G F LA + + S+ AA+ G + P + Sbjct: 262 TTMQVEAVDTLAAGDIFHGT--FALAMAEGMQSRAAVRLSSVAAALKCTVFGGRIGAPTR 319 Query: 315 KDLP 318 ++ Sbjct: 320 EETE 323 >4LC4-A nrPDB Length = 352 Score = 179 bits (455), Expect = 1e-45, Method: Composition-based stats. Identities = 70/324 (21%), Positives = 122/324 (37%), Gaps = 43/324 (13%) Query: 17 AVVVVGSCMTDLVSLTSR----------------LPKTGETIHGH--KFFIGFGGKGANQ 58 V+ VG+ + D++S + + E ++ GG N Sbjct: 27 DVLTVGNAIVDIISRCNDQFLIDNQITKAAMNLIDAERAELLYSRMGPALEASGGSAGNT 86 Query: 59 CVQAARLGAMTSMVCKVGKDSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQ 118 A LG + V D G+ + +++ + + + T + I V +G+ Sbjct: 87 AAGVANLGGKAAYFGNVAADQLGDIFTHDIRAQGVHYQTKPKGAFPPTARSMIFVTEDGE 146 Query: 119 NIIVIVAGANLLLNTEDLRAAANVISRAKVMVCQLE-ITPATSLEAL----TMARRSGVK 173 + GA + L ED+ A +V++ AKV + P + EA+ +A + G + Sbjct: 147 RSMNTYLGACVELGPEDVEA--DVVADAKVTYFEGYLWDPPRAKEAILDCARIAHQHGRE 204 Query: 174 TLFNPAPA--IADLDPQFYTL-----SDVFCCNESEAEILTGLTVGSAADAGEAALVLLK 226 + + + +F L D+ N EA L D E AL + Sbjct: 205 MSMTLSDSFCVDRYRGEFLDLMRSGKVDIVFANRQEALSLY------QTDDFEEALNRIA 258 Query: 227 RGCQVVIITLGAEGCVVLSQTEPEPKHIPTEKV-KAVDTTGAGDSFVGALAFYLAYYPNL 285 C++ +T+ G V+L E ++ ++ + VDTTGAGD F A F Y Sbjct: 259 ADCKIAAVTMSENGAVILKGRER--YYVNAIRIREVVDTTGAGDLF--ASGFLYGYTQGR 314 Query: 286 SLEDMLNRSNFIAAVSVQAAGTQS 309 SLED A + +Q G + Sbjct: 315 SLEDCGKLGCLAAGIVIQQIGPRP 338 >3LHX-A nrPDB Length = 319 Score = 178 bits (452), Expect = 2e-45, Method: Composition-based stats. Identities = 64/326 (19%), Positives = 106/326 (32%), Gaps = 49/326 (15%) Query: 16 AAVVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCVQAARL----GAMTSM 71 + V+G CM +L + G GFGG N V AR Sbjct: 5 KKIAVIGECMIEL------------SEKGADVKRGFGGDTLNTSVYIARQVDPAALTVHY 52 Query: 72 VCKVGKDSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNIIVIV---AGAN 128 V +G DSF ++ ++ T T + ++ G I ++ G+ A A Sbjct: 53 VTALGTDSFSQQMLDAWHGENVDTSLTQRMENRLPGLYYIETDSTGERTFYYWRNEAAAK 112 Query: 129 LLLNTEDLRAAANVISRAKVMVCQL-------EITPATSLEALTMARRSGVKTLFN---- 177 L +E A ++ + + L L R G K +F+ Sbjct: 113 FWLASEQSAAICEELANFDYLYLSGISLAILSPTSREKLLSLLRECRAKGGKVIFDNNYR 172 Query: 178 -----PAPAIADLDPQFYTLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVV 232 + Q +D+ + + L G + G + V Sbjct: 173 PRLWASKEETQQVYQQMLECTDIAFLTLDDEDALWGQ-----QPVEDVIARTHNAGVKEV 227 Query: 233 IITLGAEGCVVLSQTEPEPKHIPT---EKVKAVDTTGAGDSFVGALAFYLAYYPNLSLED 289 ++ GA+ C+V S +P K K +DTT AGDSF + S E+ Sbjct: 228 VVKRGADSCLV-SIAGEALVDVPAVKLPKEKVIDTTAAGDSFSA--GYLAVRLTGGSAEN 284 Query: 290 MLNRSNFIAAVSVQAAGT---QSSYP 312 R + A+ +Q G + + P Sbjct: 285 AAKRGHLTASTVIQYRGAIIPREAMP 310 >4WJM-A nrPDB Length = 312 Score = 178 bits (451), Expect = 3e-45, Method: Composition-based stats. Identities = 67/315 (21%), Positives = 111/315 (35%), Gaps = 37/315 (11%) Query: 18 VVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGF-GGKGANQCVQAARLGAMTSMVCKVG 76 ++ G + D++ ET G F F GG N + RLG T + Sbjct: 8 ILCCGEALIDML--------PRETTGGETAFQPFAGGSVFNTAIALGRLGVPTGFFSGIS 59 Query: 77 KDSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNIIVIVAGANLLLNTEDL 136 D FG+ + L ++++ F + T +V+ + + A +L+ D+ Sbjct: 60 SDFFGDVLRDTLARSNVDYSFAAISNRPTTLAFVRLVDGQARYAFYDENTAGRMLSRNDM 119 Query: 137 RAAANVISRAKVMVCQLEITPATSLEALTMARRSGVKTLFNPAPAIADLD---------- 186 IS L P S+ +AR + + +F A+L Sbjct: 120 PYVDETISAMLFGCISLISEPCGSVYETLLAREAPNRVMFLDPNIRANLITVRKTHLTRM 179 Query: 187 PQFYTLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLGAEGCVVLSQ 246 + L+D+ ++ + + G E A LK G ++V+IT GA G V + Sbjct: 180 KRMIALADIVKLSDEDLDWF-----GEKGSHDEIAAEWLKLGPKLVVITKGAHGAVAYTN 234 Query: 247 TEPEPKHIPTEKVKAVDTTGAGDSFVGALAF-----------YLAYYPNLSLEDMLNRSN 295 +P KV VDT GAGD+ + LA + + Sbjct: 235 H--ATVPVPGVKVDVVDTVGAGDTVNAGILASLHSQGLLTKDALANLSEDQIHSAVALGV 292 Query: 296 FIAAVSVQAAGTQSS 310 AAV+V AG Sbjct: 293 RAAAVTVSRAGANPP 307 >3LJS-A nrPDB Length = 338 Score = 172 bits (435), Expect = 2e-43, Method: Composition-based stats. Identities = 70/329 (21%), Positives = 126/329 (38%), Gaps = 38/329 (11%) Query: 16 AAVVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCVQAARLGAMTSMVCKV 75 ++ G + D+++ L K G F GG AN V ARLG V + Sbjct: 5 KTILCFGEALIDMLA--QPLVKKG---MPRAFLQCAGGAPANVAVAVARLGGAVQFVGML 59 Query: 76 GKDSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNIIVIV--AGANLLLNT 133 G D FG+ ++ + + T+ +T A T A + ++ G+ A+LL Sbjct: 60 GSDMFGDFLFDSFAEAGVVTDGIVRTSTAKTALAFVALDAHGERSFSFYRPPAADLLFRV 119 Query: 134 EDLRAAANVISRAKVMVCQLEITP----ATSLEALTMARRSGVKTLFN------PAPAIA 183 E + A + C +T + E + A+ +G F+ P Sbjct: 120 EHFQDA-SFSDALIFHACSNSMTDADIAEVTFEGMRRAQAAGAIVSFDLNFRPMLWPNGE 178 Query: 184 DLDPQFY---TLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLGAEG 240 + + + +L+DV + E + L AADA L + Q++++T A Sbjct: 179 NPASRLWKGLSLADVVKLSSEELDYLANTL---AADANAVIQQLWQGRAQLLLVTDAA-- 233 Query: 241 CVVLSQTEPEPKHIPTEKVKAVDTTGAGDSFVGALAFYLAY------------YPNLSLE 288 V T +PT +V+ D+ AGD+FVG + + A + S+ Sbjct: 234 GPVHWYTRTAGGEVPTFRVQVQDSNAAGDAFVGGMLYTFAQQFDDAAALIDFCHDPESIV 293 Query: 289 DMLNRSNFIAAVSVQAAGTQSSYPYKKDL 317 L + + A++V G ++ P ++ Sbjct: 294 STLRFAAAVGALAVTRQGAFTAMPMLSEV 322 >2HW1-A nrPDB Length = 298 Score = 170 bits (431), Expect = 7e-43, Method: Composition-based stats. Identities = 61/306 (19%), Positives = 117/306 (38%), Gaps = 41/306 (13%) Query: 14 EVAAVVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCVQAARLGAMTSMVC 73 E ++ VG + D++SL + PK I GG +N C + LGA + + Sbjct: 2 EEKQILCVGLVVLDVISLVDKYPKEDSEIRCLSQRWQRGGNASNSCTVLSLLGAPCAFMG 61 Query: 74 KVGKDSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNIIVIVAGANLLLNT 133 + + +++L++ + +T + A++I+N +G+ +L Sbjct: 62 SMAPGHVADFVLDDLRRYSVDLRYTVFQTTGSVPIATVIINE--------ASGSRTILYY 113 Query: 134 EDLRAAANVISRAKVMVCQ---LEITPATSLEALTMARRSGVKTLFNPAP-----AIADL 185 + + KV + Q + I + E + M +R P ++ Sbjct: 114 DRSLPDVSATDFEKVDLTQFKWIHIEGRNASEQVKMLQRIDAHNTRQPPEQKIRVSVEVE 173 Query: 186 DP-----QFYTLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVII------ 234 P Q + DV ++ A+ L SA +A +++G +V Sbjct: 174 KPREELFQLFGYGDVVFVSKDVAKHL---GFQSAEEALRGLYGRVRKGAVLVCAWAEEGA 230 Query: 235 -TLGAEGCVVLSQTEPEPKHIPTEKVKAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNR 293 LG +G ++ S P P + VDT GAGD+F ++ F L+ S+++ L Sbjct: 231 DALGPDGKLLHSDAFPPP--------RVVDTLGAGDTFNASVIFSLS--QGRSVQEALRF 280 Query: 294 SNFIAA 299 +A Sbjct: 281 GCQVAG 286 >3LOO-A nrPDB Length = 365 Score = 167 bits (423), Expect = 6e-42, Method: Composition-based stats. Identities = 60/302 (19%), Positives = 119/302 (39%), Gaps = 26/302 (8%) Query: 28 LVSLTSRLPKTGETIHGHKFFIGFGGKGAN---QCVQAARLGAMTSMVCKVGKDSFGNDY 84 +++ +P E I ++ GG N + VG+D + Sbjct: 56 ILAEEKHMPMYQELIEKYQAEYIAGGSVQNSLRVAQWILQRPRTAIFFGCVGQDEYARIL 115 Query: 85 IENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNIIVIVAGANLLLNTEDLRAAAN--V 142 E N ++ ++ ++ + TGT +++V +++ +A AN E LR+ N Sbjct: 116 EERATSNGVNVQYQ-RSATSPTGTCAVLVTGTQRSLCANLAAAND-FTPEHLRSDGNRAY 173 Query: 143 ISRAKVMVCQLE---ITPATSLEALTMARRSGVKTLFN-PAPAIADLD----PQFYTLSD 194 + A+ ++ ++L A +G + N AP + + + D Sbjct: 174 LQGAQFFYVSGFFFTVSFESALSVAKEAAATGRMFMMNLSAPFVPQFYKNNLEEIFPYVD 233 Query: 195 VFCCNESEAEILT---GLTVGSAADAGEAALVLLK---RGCQVVIITLGAEGCVVLSQTE 248 V NE+EA L + G+ L K + ++VIIT G++ +++ Sbjct: 234 VLFGNETEAIALAKEFNYGTEDLREIGKRIAALPKENGKRKRIVIITQGSDPVLLIEAGT 293 Query: 249 PEPKHIPTEKV---KAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFIAAVSVQAA 305 + P +K+ + VDT GAGD+FVG F + +++ + + A +Q + Sbjct: 294 DNVREFPVQKLAPEQMVDTNGAGDAFVG--GFLAQLLQSRTVDVCIKCGIWAAREIIQRS 351 Query: 306 GT 307 G Sbjct: 352 GC 353 >2VAR-A nrPDB Length = 313 Score = 166 bits (420), Expect = 1e-41, Method: Composition-based stats. Identities = 59/322 (18%), Positives = 110/322 (34%), Gaps = 29/322 (9%) Query: 15 VAAVVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCVQAARLGAMTSMVCK 74 + V+ +G + S G + F G N C+ R S++ + Sbjct: 1 MVDVIALGEPLIQFNSF-----NPGPLRFVNYFEKHVAGSELNFCIAVVRNHLSCSLIAR 55 Query: 75 VGKDSFGNDYIENLKQNDISTEFTYQTKDAATGTASII----VNNEGQNIIVIVAGANLL 130 VG D FG + IE + I T ++ TG I + + + + A Sbjct: 56 VGNDEFGKNIIEYSRAQGIDTSHIKVDNESFTGIYFIQRGYPIPMKSELVYYRKGSAGSR 115 Query: 131 LNTEDLRA----AANVISRAKVMVCQLEITPATSLEALTMARRSGVKTLFNP--APAIAD 184 L+ ED+ + ++ + + + ++A +A+ + T P ++ Sbjct: 116 LSPEDINENYVRNSRLVHSTGITLAISDNAKEAVIKAFELAKSRSLDTNIRPKLWSSLEK 175 Query: 185 LDPQFYTL-----SDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLGAE 239 ++ +V + + +IL D EA + G +V++ LG++ Sbjct: 176 AKETILSILKKYDIEVLITDPDDTKILL-----DVTDPDEAYRKYKELGVKVLLYKLGSK 230 Query: 240 GCVVLSQTEPEPKHIPTEKVKAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFIAA 299 G + K KV D TGAGD+ G F Y +E L + Sbjct: 231 GAIAYKDNVKAFKD--AYKVPVEDPTGAGDAMAGT--FVSLYLQGKDIEYSLAHGIAAST 286 Query: 300 VSVQAAGTQSSYPYKKDLPLTL 321 + + G P +D L Sbjct: 287 LVITVRGDNELTPTLEDAERFL 308 >3GO6-A nrPDB Length = 310 Score = 163 bits (413), Expect = 8e-41, Method: Composition-based stats. Identities = 85/296 (28%), Positives = 118/296 (39%), Gaps = 31/296 (10%) Query: 15 VAAVVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCVQAARLGAMTSMVCK 74 V VVGS DL + LP+ GET+ GGKGANQ V AAR GA Sbjct: 19 APRVCVVGSVNMDLTFVVDALPRPGETVLAASLTRTPGGKGANQAVAAARAGAQVQFSGA 78 Query: 75 VGKDSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNIIVIVAGANLLLNTE 134 G D +L+ N + + T T +GTA I+V+ +N +++ GAN L Sbjct: 79 FGDDPAAAQLRAHLRANAVGLDRTV-TVPGPSGTAIIVVDASAENTVLVAPGANAHLTP- 136 Query: 135 DLRAAANVISRAKVMVCQLEITPATSLEALTMARRSGVKTLFNPAPAIADLD--PQFYTL 192 + ++ V++ QLEI AT+L A A+ + + N +PA D + Sbjct: 137 ----VPSAVANCDVLLTQLEIPVATALAAARAAQSADAVVMVNASPAGQDRSSLQDLAAI 192 Query: 193 SDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLGAEGCVVLSQTEPEPK 252 +DV NE EA +ITLG G + Sbjct: 193 ADVVIANEHEANDWPSPPTH-------------------FVITLGVRGARYVGADG--VF 231 Query: 253 HIPTEKVKAVDTTGAGDSFVGALAFYLAYYPNLSLE--DMLNRSNFIAAVSVQAAG 306 +P V VDT GAGD F G LA P E L R+ A++ +G Sbjct: 232 EVPAPTVTPVDTAGAGDVFAGVLAANWPRNPGSPAERLRALRRACAAGALATLVSG 287 >2QHP-A nrPDB Length = 296 Score = 161 bits (407), Expect = 3e-40, Method: Composition-based stats. Identities = 62/274 (22%), Positives = 109/274 (39%), Gaps = 16/274 (5%) Query: 49 IGFGGKGANQCVQAARLGAMTSMVCKVGKDSFGNDYIENLKQNDISTEFTYQTKDAATGT 108 GG AN ++ G + +V VG D G++ +E K+ + + + D TGT Sbjct: 21 KKIGGAPANFAYHVSQFGFDSRVVSAVGNDELGDEIMEVFKEKQLKNQI--ERVDYPTGT 78 Query: 109 ASIIVNNEGQNIIVI---VAGANLLLNTEDLRAAANVISRAKVMVCQ-LEITPATSLEAL 164 + +++EG I VA N+ E R A N + + Q E++ AT L Sbjct: 79 VQVTLDDEGVPCYEIKEGVAWDNIPFTDELKRLALNTRAVCFGSLAQRNEVSRATINRFL 138 Query: 165 -TMARRSGVKTLFNPAPA----IADLDPQFYTLSDVFCCNESEAEILTGLTVGSAADAGE 219 TM G +F+ ++ + + ++ N+ E ++ + D + Sbjct: 139 DTMPDIDGQLKIFDINLRQDFYTKEVLRESFKRCNILKINDEELVTISRMFGYPGIDLQD 198 Query: 220 AALVLL-KRGCQVVIITLGAEGCVVLSQTEPEPKHIPTEKVKAVDTTGAGDSFVGALAFY 278 +LL K +++I+T G G V + + P KV DT GAGDSF A Sbjct: 199 KCWILLAKYNLKMLILTCGINGSYVFTPGVVSFQETP--KVPVADTVGAGDSFTAAFC-- 254 Query: 279 LAYYPNLSLEDMLNRSNFIAAVSVQAAGTQSSYP 312 + S+ + + ++A +G P Sbjct: 255 ASILNGKSVPEAHKLAVEVSAYVCTQSGAMPELP 288 >3NCA-A nrPDB Length = 313 Score = 159 bits (401), Expect = 2e-39, Method: Composition-based stats. Identities = 60/305 (19%), Positives = 111/305 (36%), Gaps = 43/305 (14%) Query: 16 AAVVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCVQAARLGAMTSMVCKV 75 + ++ VG + D++SL + PK I GG +N C + LGA + + + Sbjct: 19 SQILCVGLVVLDVISLVDKYPKEDSEIRCLSQRWQRGGNASNSCTVLSLLGAPCAFMGSM 78 Query: 76 GKDSFGNDYIENLKQNDISTEFTYQTKDAATG-TASIIVNNEGQNIIVIVAGANLLLNTE 134 + + + ++ + T + II N+ G IV+ + Sbjct: 79 APGHVADFLVADFRRRGVDVSQVAWQSKGDTPSSCCIINNSNGNRTIVLH---------D 129 Query: 135 DLRAAANVISRAKVMVCQ---LEITPATSLEALTMARRSGVKTLFNPAP-----AIADLD 186 + KV + Q + I + E + M +R P ++ Sbjct: 130 TSLPDVSATDFEKVDLTQFKWIHIEGRNASEQVKMLQRIDAHNTRQPPEQKIRVSVEVEK 189 Query: 187 P-----QFYTLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVII------- 234 P Q + DV ++ A+ L SA +A +++G +V Sbjct: 190 PREELFQLFGYGDVVFVSKDVAKHL---GFQSAEEALRGLYGRVRKGAVLVCAWAEEGAD 246 Query: 235 TLGAEGCVVLSQTEPEPKHIPTEKVKAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRS 294 LG +G ++ S P P + VDT GAGD+F ++ F L+ S+++ L Sbjct: 247 ALGPDGKLLHSDAFPPP--------RVVDTLGAGDTFNASVIFSLS--QGRSVQEALRFG 296 Query: 295 NFIAA 299 +A Sbjct: 297 CQVAG 301 >2NWH-A nrPDB Length = 317 Score = 158 bits (398), Expect = 5e-39, Method: Composition-based stats. Identities = 77/311 (24%), Positives = 126/311 (40%), Gaps = 23/311 (7%) Query: 14 EVAAVVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCVQAARLGAMTSMVC 73 + ++V+G D + G + G GG G N +RLG ++ Sbjct: 2 HMKKILVLGGAHIDRRGMIETETAPGASNPGSWMEE-AGGGGFNAARNLSRLGFEVRIIA 60 Query: 74 KVGKDSFGNDYIENLKQNDI-STEFTYQTKDAATGTASIIVNNEGQNIIVIVAGANLL-- 130 G D G E +Q + T FT+ + + TA + + N+++ +A +L Sbjct: 61 PRGGDVTGEVVAEAARQAGVEDTPFTFLDRRTPSYTAILERDG---NLVIALADMDLYKL 117 Query: 131 LNTED--LRAAANVISRAKVMVCQLEITPATSLEALTMARRSGVKTL--FNPAPAIADLD 186 +RA I + ++C + P +L AL + R+ K L +PA A Sbjct: 118 FTPRRLKVRAVREAIIASDFLLCDANL-PEDTLTALGLIARACEKPLAAIAISPAKAVKL 176 Query: 187 PQFYTLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLGAEGCVVLSQ 246 D+ NE+EA LTG T + D +L K G ++T GA V + Sbjct: 177 KAALGDIDILFMNEAEARALTGETAENVRDWPN---ILRKAGLSGGVVTRGASEVVAFNG 233 Query: 247 TEPEPKHIPTEKVKAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFIAAVSVQAAG 306 TE H P + + D TGAGD+ A + A ++ + L + AA++V Sbjct: 234 TEKAILHPPLIR-EVKDVTGAGDAM--ASGYLAAIAEGKTIREALRQGAAAAAITV---- 286 Query: 307 TQSSYPYKKDL 317 QSS+ +DL Sbjct: 287 -QSSFATSQDL 296 >3N1C-A nrPDB Length = 309 Score = 148 bits (373), Expect = 3e-36, Method: Composition-based stats. Identities = 60/281 (21%), Positives = 108/281 (38%), Gaps = 21/281 (7%) Query: 38 TGETIHGHKFFIGFGGKGANQCVQAARLGAMTSMVCKVGKDSFGNDYIENLKQNDISTEF 97 + GG G N A LG + + G + G + L ++ Sbjct: 24 PEGKLRCTAPVFEPGGGGINVARAIAHLGGSATAIFPAG-GATGEHLVSLLADENVPVA- 81 Query: 98 TYQTKDAATGTASIIVNNEGQNIIVIVAGANLLLNTEDLRAAANV---ISRAKVMVCQLE 154 T + KD + V G+ ++ GA LN ++ R I ++V Sbjct: 82 TVEAKDWTRQNLHVHVEASGEQYRFVMPGA--ALNEDEFRQLEEQVLEIESGAILVISGS 139 Query: 155 ITPATSLEALTM----ARRSGVKTLFNPAPAIADLDPQFYTLSDV--FCCNESEAEILTG 208 + P LE LT A++ G++ + + + + + ++ N+ E L Sbjct: 140 LPPGVKLEKLTQLISAAQKQGIRCIVDSS---GEALSAALAIGNIELVKPNQKELSALVN 196 Query: 209 LTVGSAADAGEAALVLLKRG-CQVVIITLGAEGCVVLSQTEPEPKHIPTEKVKAVDTTGA 267 + D +AA ++ G + V+++LG +G + + + VK+ T GA Sbjct: 197 RELTQPDDVRKAAQEIVNSGKAKRVVVSLGPQGALGV--DSENCIQVVPPPVKSQSTVGA 254 Query: 268 GDSFVGALAFYLAYYPNLSLEDMLNRSNFIAAVSVQAAGTQ 308 GDS VGA+ LA N SLE+M+ + + GT+ Sbjct: 255 GDSMVGAMTLKLA--ENASLEEMVRFGVAAGSAATLNQGTR 293 >2AA0-A nrPDB Length = 383 Score = 127 bits (320), Expect = 5e-30, Method: Composition-based stats. Identities = 69/349 (19%), Positives = 113/349 (32%), Gaps = 58/349 (16%) Query: 17 AVVVVGSCMTDLVSLTSR-------LPKTGETIHGHKFFIG------------FGGKGAN 57 V +G+ + DLV+ L + T+ + GG N Sbjct: 34 RVFAIGNPILDLVAEVPSSFLDEFFLKRGDATLATPEQMRIYSTLDQFNPTSLPGGSALN 93 Query: 58 QCVQAARL---GAMTSMVCKVGKDSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVN 114 +L + +G D G E + ++T F +TG ++++N Sbjct: 94 SVRVVQKLLRKPGSAGYMGAIGDDPRGQVLKELCDKEGLATRFMV-APGQSTGVCAVLIN 152 Query: 115 NEGQNIIVIVAGANLLLN-TEDLRAAANVISRAKVMVCQLEITPATSLEALTMARR--SG 171 + + + GA ED A+ L TP +LE A + Sbjct: 153 EK-ERTLCTHLGACGSFRLPEDWTTFASGALIFYATAYTLTATPKNALEVAGYAHGIPNA 211 Query: 172 VKTLFNPAPAIADLDPQ----FYTLSDVFCCNESEAEILTGL--------------TVGS 213 + TL AP +L +++ NE E L + Sbjct: 212 IFTLNLSAPFCVELYKDAMQSLLLHTNILFGNEEEFAHLAKVHNLVAAEKTALSTANKEH 271 Query: 214 AADAGEAALVLLKRGC-----QVVIITLGAEGCVVLSQTEPEPKHIPT------EKVKAV 262 A + AL LL G ++V++T G + QT + K V Sbjct: 272 AVEVCTGALRLLTAGQNTSATKLVVMTRGHNPVIAAEQTADGTVVVHEVGVPVVAAEKIV 331 Query: 263 DTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFIAAVSVQAAGTQSSY 311 DT GAGD+FVG F A +++ + N A +Q G S+ Sbjct: 332 DTNGAGDAFVG--GFLYALSQGKTVKQCIMCGNACAQDVIQHVGFSLSF 378 >3UQ9-A nrPDB Length = 372 Score = 116 bits (289), Expect = 2e-26, Method: Composition-based stats. Identities = 58/302 (19%), Positives = 110/302 (36%), Gaps = 26/302 (8%) Query: 28 LVSLTSRLPKTGETIHGHKFFIGFGGKGANQCVQA---ARLGAMTSMVCKVGKDSFGNDY 84 +++ + E K GG N + + S V +G D G Sbjct: 59 VLAEEKHMTIYDEIQKKKKLNYIAGGATLNTVKMIQWIIQKPFVCSYVGCIGADIQGKYI 118 Query: 85 IENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNIIVIVAGANLLLNTEDLRAA--ANV 142 + D+ TEF + TG +++V+ + +V GA L+ + ++ Sbjct: 119 KNDCSALDLVTEFQIAEEPLMTGKVAVLVSEK-LRSMVTYLGAACDLSLAHIEQPHVWSL 177 Query: 143 ISRAKVMVCQLEITP---ATSLEALTMARRSGVKTLFN-PAPAIADLD----PQFYTLSD 194 + +A+V + L+ + + FN AP ++ + + + S+ Sbjct: 178 VEKAQVYYIAGFVINTCYEGMLKIAKHSLENEKLFCFNLSAPFLSQFNTKEVDEMISYSN 237 Query: 195 VFCCNESEAE-------ILTGLTVGSAADAGEAALVLLKRGCQVVIITLGAEGCVVLSQT 247 + NESEAE +L +A + K+ ++VIIT G + + Sbjct: 238 IVFGNESEAEAYGEVHGLLEDTVHATARYIADLPFADGKKRKRLVIITRGKNPLLYTDSS 297 Query: 248 EPEPKHIPTEK---VKAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFIAAVSVQA 304 + E E+ + +DT GAGD+F F Y + L+ + AA + Sbjct: 298 DSEIHQFMVEQFKDDQIIDTNGAGDAFAA--GFIADYIRGKPMITSLHAAVKAAAYIICR 355 Query: 305 AG 306 +G Sbjct: 356 SG 357 >2ABQ-A nrPDB Length = 306 Score = 115 bits (287), Expect = 3e-26, Method: Composition-based stats. Identities = 57/300 (19%), Positives = 107/300 (35%), Gaps = 25/300 (8%) Query: 26 TDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCVQAARLGAMTSMVCKVGKDSFGNDYI 85 D + + G + GGKG N RLG T + +G G Sbjct: 11 IDYIVQVENF-QQGVVNRSERDRKQPGGKGINVSRVLKRLGHETKALGFLG-GFTGAYVR 68 Query: 86 ENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNIIVIVAGANLLLNTEDLRAAANVI-- 143 L++ +I F D I V +G+ + A L+ E ++A + Sbjct: 69 NALEKEEIGLSFIEVEGDTR-----INVKIKGKQETELNGTAPLIKK-EHVQALLEQLTE 122 Query: 144 -SRAKVMVCQLEIT---PATSLEALT-MARRSGVKTLFNPAPAIADLDPQFYTLSDVFCC 198 + V+V + P T ++T +A+ G + + L Sbjct: 123 LEKGDVLVLAGSVPQAMPQTIYRSMTQIAKERGAFVAVDTS--GEALHEVLAAKPSFIKP 180 Query: 199 NESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLGAEGCVVLSQTEPEPKHIPTEK 258 N E L + S DA L+ G + ++++ +G + S ++P+ + Sbjct: 181 NHHELSELVSKPIASIEDAIPHVQRLIGEGIESILVSFAGDGALFASAEGMFHVNVPSGE 240 Query: 259 VKAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFIAAVSVQAAGTQSSYPYKKDLP 318 V+ ++ GAGDS V F A SLED + + + + + G + ++++ Sbjct: 241 VR--NSVGAGDSVVA--GFLAALQEGKSLEDAVPFAVAAGSATAFSDG----FCTREEVE 292 >3KD6-A nrPDB Length = 313 Score = 114 bits (285), Expect = 6e-26, Method: Composition-based stats. Identities = 59/301 (19%), Positives = 111/301 (36%), Gaps = 34/301 (11%) Query: 17 AVVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCVQAARL-GAMTSMVCKV 75 +++V+GS D + + ++ T+ GG + A+ MV V Sbjct: 4 SLLVIGSLAFDDI--ETPFGRSDNTL---------GGSSTYIALSASYFTDEPIRMVGVV 52 Query: 76 GKDSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNIIVIVAGANLLLNT-- 133 G D FG ++ + L +I T +D T + + + + + LN Sbjct: 53 GSD-FGKEHFDLLHAKNIDTRGIQVIEDGKTFRWAGRYHYD----MNTRDTLDTQLNVFA 107 Query: 134 EDLRAAANVISRAKVMVCQLEITPATSLEALTMARRSGVKT---LFNPAPAIADLDPQFY 190 E +K VC I P L+ L + + + + Sbjct: 108 EFDPHVPQYYRDSKF-VCLGNIDPELQLKVLDQIDDPKLVVCDTMNFWIEGKPEELKKVL 166 Query: 191 TLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLGAEGCVVLSQTEPE 250 DVF N+SEA +L+G + + A ++ + G + +II G G ++ + Sbjct: 167 ARVDVFIVNDSEARLLSG-----DPNLVKTARIIREMGPKTLIIKKGEHGALLFTDNG-- 219 Query: 251 PKHIPTEKVKAV-DTTGAGDSFVGALAFYLAY---YPNLSLEDMLNRSNFIAAVSVQAAG 306 P ++++ D TGAGD+F G +LA + + + +A+ V+ G Sbjct: 220 IFAAPAFPLESIYDPTGAGDTFAGGFIGHLARCGNTSEAEMRKAVLYGSAMASFCVEQFG 279 Query: 307 T 307 Sbjct: 280 P 280 >3B1N-A nrPDB Length = 326 Score = 113 bits (283), Expect = 1e-25, Method: Composition-based stats. Identities = 54/318 (16%), Positives = 106/318 (33%), Gaps = 34/318 (10%) Query: 15 VAAVVVVGSCMTDLVSLTSRLPKT----------GETIHGHKFFIGFGGKGANQCVQAAR 64 +A ++ GS D + + + FGG N Sbjct: 1 MATLIC-GSIAYDNIMTFEGRFREHILPDQVHLINLSFLVPTMRREFGGCAGNIAYALNL 59 Query: 65 LGAMTSMVCKVGKDSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNIIVIV 124 LG M+ +G Y++ + +S E+ D + A I + + I Sbjct: 60 LGGDARMMGTLGA-VDAQPYLDRMDALGLSREYVRVLPDTYSAQAMITTDLDNNQITAFH 118 Query: 125 AGANLLLNTEDLRAAANVISRAKVMVCQLEITPATSLEALTMARRSGVKTLFNPAPAIAD 184 GA + + A ++ + ++ ++GV +F+P + Sbjct: 119 PGAMMQSHVNHAGEAKDIK-----LAIVGPDGFQGMVQHTEELAQAGVPFIFDPGQGLPL 173 Query: 185 LD----PQFYTLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLGAEG 240 D + L+ N+ EA+++ T S + Q +IIT G G Sbjct: 174 FDGATLRRSIELATYIAVNDYEAKLVCDKTGWSEDEIAS--------RVQALIITRGEHG 225 Query: 241 CVVLSQTEPEPKHIPTEKVK-AVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFIAA 299 + + E IP + + +D TG GD+F G L + ++ + A Sbjct: 226 ATIRHRDGTE--QIPAVRAERVIDPTGCGDAFRGGLLY--GIEHGFDWATAGRLASLMGA 281 Query: 300 VSVQAAGTQSSYPYKKDL 317 + + G Q+ P + ++ Sbjct: 282 LKIAHQGPQTYAPTRAEI 299 >4E84-A nrPDB Length = 352 Score = 111 bits (276), Expect = 6e-25, Method: Composition-based stats. Identities = 62/316 (19%), Positives = 109/316 (34%), Gaps = 29/316 (9%) Query: 7 PQRQWQEEVAAVVVVGSCMTDLVS--LTSRL-PK-TGETIHGHKFFIGFGGKGANQCVQA 62 P + Q + V+VVG M D R+ P+ +H + GG AN A Sbjct: 45 PVPREQLARSRVLVVGDVMLDRYWFGNVDRISPEAPVPVVHVQRQEERLGGA-ANVARNA 103 Query: 63 ARLGAMTSMVCKVGKDSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNIIV 122 LG ++C VG D G +E L + + T + T ++ + Q + V Sbjct: 104 VTLGGQAGLLCVVGCDEPGERIVELLGSSGV-TPHLERDPALPTTIKLRVLARQQQLLRV 162 Query: 123 IVAGANLLLNTEDLRAAANVISRAKVMVCQLEITPATSLEA---------LTMARRSGVK 173 ++R V++ Q ++ + + AR +G Sbjct: 163 DFEAMPTH------EVLLAGLARFDVLLPQHDVVLMSDYAKGGLTHVTTMIEKARAAGKA 216 Query: 174 TLFNPAPAIADLDPQFYTLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVI 233 L +P Y + + N +E + G A + + ++ Sbjct: 217 VLVDPKGDDWAR----YRGASLITPNRAELREVVGQWKSEDDLRARVANLRAELDIDALL 272 Query: 234 ITLGAEGCVVLSQTEPEPKHIPTEKVKAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNR 293 +T EG + S H P + D +GAGD+ + +A L + L D + Sbjct: 273 LTRSEEGMTLFSAGGE--LHAPALAREVFDVSGAGDTVIATVATMLGA--GVPLVDAVVL 328 Query: 294 SNFIAAVSVQAAGTQS 309 +N A + V GT + Sbjct: 329 ANRAAGIVVGKLGTAT 344 >6C9R-A nrPDB Length = 337 Score = 109 bits (271), Expect = 2e-24, Method: Composition-based stats. Identities = 59/306 (19%), Positives = 101/306 (33%), Gaps = 27/306 (8%) Query: 18 VVVVGSCMTDLV----------SLTSRLPKTGETIHGHKFFIGFGGKGANQCVQAARLGA 67 + V GS TD + L L K + + GG N LG Sbjct: 16 IAVTGSIATDHLMRFPGRFSEQLLPEHLHKVSLSFLVDDLVMHRGGVAGNMAFAIGVLGG 75 Query: 68 MTSMVCKVGKDSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNIIVIVAGA 127 ++V G D DY + LK ++ + ++ A T + + + I GA Sbjct: 76 EVALVGAAGADF--ADYRDWLKARGVNCDHVLISETAHTARFTCTTDVDMAQIASFYPGA 133 Query: 128 NLLLNTEDLRAAANVISRAKVMVCQLEITPATSLEALTMARRSGVKTLFNPAPAIADLDP 187 L + I + + +V P R+ G+ +P+ +A L Sbjct: 134 MSEARNIKLADVVSAIGKPE-LVIIGANDPEAMFLHTEECRKLGLAFAADPSQQLARLSG 192 Query: 188 QFYTL----SDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLGAEGCVV 243 + + N+ E ++L T S AD + + TLG +G + Sbjct: 193 EEIRRLVNGAAYLFTNDYEWDLLLSKTGWSEADVMAQ--------IDLRVTTLGPKGVDL 244 Query: 244 LSQTEPEPKHIPTEKVKAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFIAAVSVQ 303 + + D TG GD+F F L LE + +A + ++ Sbjct: 245 VEPDGTTIHVGVVPETSQTDPTGVGDAFRA--GFLTGRSAGLGLERSAQLGSLVAVLVLE 302 Query: 304 AAGTQS 309 + GTQ Sbjct: 303 STGTQE 308 >4E69-A nrPDB Length = 328 Score = 106 bits (265), Expect = 1e-23, Method: Composition-based stats. Identities = 63/325 (19%), Positives = 103/325 (31%), Gaps = 48/325 (14%) Query: 13 EEVAAVVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCVQAARLGAMTS-- 70 + + ++ +G CM +L + +GF G N ARL + Sbjct: 21 QSMMHILSIGECMAEL----------APADLPGTYRLGFAGDTFNTAWYLARLRPESRIS 70 Query: 71 MVCKVGKDSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNIIVIVAG--AN 128 +G D+ + I G I + +G+ G A Sbjct: 71 YFSAIGDDALSQQMRAAMSAAGIDGGGLRVIPGRTVGLYLITL-EQGERSFAYWRGQSAA 129 Query: 129 LLL-----NTEDLRAAANVISRAKVMVCQLEI-TPATSLEALTMARRSGVKTLFNPAPAI 182 L A A+V+ + + + L+ AT L AL AR +G F+P Sbjct: 130 RELAGDADALAAAMARADVVYFSGITLAILDQCGRATLLRALAQARATGRTIAFDP---- 185 Query: 183 ADLDPQFY--------------TLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRG 228 +L P+ + +SD+ + + G A A + G Sbjct: 186 -NLRPRLWAGTGEMTETIMQGAAVSDIALPSFEDEAAWFGDAGPDAT-----ADRYARAG 239 Query: 229 CQVVIITLGAEGCVVLSQTEPEPKHIPTEKVKAVDTTGAGDSFVGALAFYLAYYPNLSLE 288 + V++ G V Q + + VDTT AGDSF L + LE Sbjct: 240 VRSVVVKNGPH-AVHFLQDGRRGRVPVPPVAQVVDTTAAGDSFNAGL--LDSVLAGQPLE 296 Query: 289 DMLNRSNFIAAVSVQAAGTQSSYPY 313 + + +A VQ G P Sbjct: 297 TAIAAAAALAGQVVQGKGALVEVPS 321 >2AFB-A nrPDB Length = 351 Score = 106 bits (263), Expect = 2e-23, Method: Composition-based stats. Identities = 64/324 (19%), Positives = 105/324 (32%), Gaps = 42/324 (12%) Query: 17 AVVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCVQAARLGAMTSMVCKVG 76 VV G M L P F + +GG AN A++G V K+ Sbjct: 14 KVVTFGEIMLRL-----SPPDHKRIFQTDSFDVTYGGAEANVAAFLAQMGLDAYFVTKLP 68 Query: 77 KDSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNIIVIVAGANLLLNT--- 133 + G+ +L++ + T++ + + G + + + V+ A+ ++ Sbjct: 69 NNPLGDAAAGHLRKFGVKTDYIARGGN-RIGIYFLEIGASQRPSKVVYDRAHSAISEAKR 127 Query: 134 EDLRAAANVISRAKVMVCQLEITP-----ATSLE-ALTMARRSGVKTL--FNPAPAIADL 185 ED ++ A+ P LE AL +A GV N + Sbjct: 128 EDFDWEK-ILDGARWFHFSGITPPLGKELPLILEDALKVANEKGVTVSCDLNYRARLWTK 186 Query: 186 DPQ------FYTLSDVFCCNESEAEILTGLTVG----------SAADAGEAALVLLKRGC 229 + F DV NE + E + G++V A A A V K Sbjct: 187 EEAQKVMIPFMEYVDVLIANEEDIEKVLGISVEGLDLKTGKLNREAYAKIAEEVTRKYNF 246 Query: 230 QVVIITL--GAEGCVVLSQT----EPEPKHIPTEKVKAVDTTGAGDSFVGALAFYLAYYP 283 + V ITL V +P ++ VD GAGDSF GAL + Sbjct: 247 KTVGITLRESISATVNYWSVMVFENGQPHFSNRYEIHIVDRVGAGDSFAGALIYGSLM-- 304 Query: 284 NLSLEDMLNRSNFIAAVSVQAAGT 307 + + + + G Sbjct: 305 GFDSQKKAEFAAAASCLKHTIPGD 328 >2JG5-A nrPDB Length = 306 Score = 103 bits (256), Expect = 1e-22, Method: Composition-based stats. Identities = 57/281 (20%), Positives = 106/281 (37%), Gaps = 17/281 (6%) Query: 26 TDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCVQAARLGAMTSMVCKVGKDSFGNDYI 85 D V T+ K + GGKG N L ++ + G G I Sbjct: 11 IDYVIFTNDF-KIDGLNRATATYKFAGGKGINVSRVLKTLDVESTALGFAG-GFPGKFII 68 Query: 86 ENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNIIVIVAGANLLLNT-EDLRAAANVIS 144 + L + I + F +D GQ + G ++ E L + Sbjct: 69 DTLNNSAIQSNFIEVDEDTRINVKL----KTGQETEINAPGPHITSTQFEQLLQQIKNTT 124 Query: 145 RAKVMVCQLEITPATSLEA----LTMARRSGVKTLFNPAPAIADLDPQFYTLSDVFCCNE 200 +++ + + +A + ++G K + + +A+ ++ L N+ Sbjct: 125 SEDIVIVAGSVPSSIPSDAYAQIAQITAQTGAKLVVDAEKELAESVLPYHPL--FIKPNK 182 Query: 201 SEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLGAEGCVVLSQTEPEPKHIPTEKVK 260 E E++ TV S AD + +L+ +G Q VI++LG +G + + + P KV Sbjct: 183 DELEVMFNTTVNSDADVIKYGRLLVDKGAQSVIVSLGGDGAIYIDKEISIKAVNPQGKV- 241 Query: 261 AVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFIAAVS 301 V+T G+GDS V + +A LS+E ++ + Sbjct: 242 -VNTVGSGDSTVAGMVAGIA--SGLSIEKAFQQAVACGTAT 279 >3JUL-A nrPDB Length = 320 Score = 101 bits (250), Expect = 6e-22, Method: Composition-based stats. Identities = 55/295 (18%), Positives = 109/295 (36%), Gaps = 18/295 (6%) Query: 23 SCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCVQAARLGAMTSMVCKVGKDSFGN 82 + D + + +T K GGKG + ++ G + G D+ + Sbjct: 10 NPAIDRLLFIRGELEKRKTNRVIKTEFDCGGKGLHVSGVLSKFGIKNEALGIAGSDNL-D 68 Query: 83 DYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNIIVIVAGANLLLNTED--LRAAA 140 LK+ I+ +F + + ++ ++ + ++ AG + +D L+ A Sbjct: 69 KLYAILKEKHINHDFLVEAGTSTRECFVVLSDDTNGSTMIPEAGFTVSQTNKDNLLKQIA 128 Query: 141 NVISRAKVMVCQLEITPATSL----EALTMARRSGVKTLFNPAPAIADLDPQFYTLSDVF 196 + + ++V P +L E L + +G + + +L + D Sbjct: 129 KKVKKEDMVVIAGSPPPHYTLSDFKELLRTVKATGAFLGCDNSGEYLNLAVEMG--VDFI 186 Query: 197 CCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLGAEGCVVLSQTEPEPKHIPT 256 NE E + S + L ++++LGA+G + + + Sbjct: 187 KPNEDEVIAILDEKTNSLEENIRT----LAEKIPYLVVSLGAKGSICAHNGK--LYQVIP 240 Query: 257 EKVKAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFIAAVSVQAAGTQSSY 311 KV+ + TGAGD FVGA LA N+ + + L + +A V SS+ Sbjct: 241 PKVQERNDTGAGDVFVGAFIAGLAM--NMPITETLKVATGCSASKVMQQ-DSSSF 292 >2AWD-A nrPDB Length = 323 Score = 100 bits (249), Expect = 7e-22, Method: Composition-based stats. Identities = 56/300 (18%), Positives = 104/300 (34%), Gaps = 25/300 (8%) Query: 18 VVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCVQAARLGAMTSMVCKVGK 77 V V + D+ L L K + GGKG N LG +G Sbjct: 5 VTVTMNPSIDISYLLDHL-KLDTVNRTSQVTKTPGGKGLNVTRVIHDLGGDVIATGVLG- 62 Query: 78 DSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNIIVIVAGANLLLNTEDLR 137 G LK+ +I FT ++ A + EG ++ AG ++ E++ Sbjct: 63 GFHGAFIANELKKANIPQAFTSIKEETRDSIAILH---EGNQTEILEAG--PTVSPEEIS 117 Query: 138 AAAN----VISRAKVMVCQLE----ITPATSLEALTMARRSGVKTLFNPAPAIADLDPQF 189 +I +A+++ + E + A VK L + + Q Sbjct: 118 NFLENFDQLIKQAEIVTISGSLAKGLPSDFYQELVQKAHAQEVKVLLDTSGDSLRQVLQG 177 Query: 190 YTLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKR----GCQVVIITLGAEGCVVLS 245 + N E E L G + A L + G + ++I+LG +G + + Sbjct: 178 PWKPYLIKPNLEELEGLLGQDFSE--NPLAAVQTALTKPMFAGIEWIVISLGKDGAI--A 233 Query: 246 QTEPEPKHIPTEKVKAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFIAAVSVQAA 305 + + + ++A + G+GD+ + LA+ LA + ++L + Q Sbjct: 234 KHHDQFYRVKIPTIQAKNPVGSGDATIAGLAYGLA--KDAPAAELLKWGMAAGMANAQER 291 >4GM6-A nrPDB Length = 351 Score = 97.2 bits (240), Expect = 8e-21, Method: Composition-based stats. Identities = 52/334 (15%), Positives = 108/334 (32%), Gaps = 35/334 (10%) Query: 5 GEPQRQWQEEVAAVVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCVQAAR 64 G +Q + VV +G + L + + I GG AN V ++ Sbjct: 14 GTENLYFQSMMKQVVTIGELLMRLSTQ-----QGIPFSQTTALDIHIGGAEANVAVNLSK 68 Query: 65 LGAMTSMVCKVGKDSFGNDYIENLKQNDISTEF---------TYQTKDAATGTASIIVNN 115 LG T + V + G +E+L ++ + T F TY + A +V + Sbjct: 69 LGHPTRIATVVPANPIGKMAVEHLWRHQVDTAFVVEAGDRLGTYYLESGTALKAPSVVYD 128 Query: 116 EGQNIIVIVAGANLLLNTEDLRAAANVISRAKVMVCQLEITPATSLEALTMARRSGVKTL 175 + + L+ L V+ + + + ++ + A+R+G+K Sbjct: 129 RQHSSFARHKSMDWDLSE--LLKGIRVLHVSGITIALSTFWLEMVVKIIREAKRNGIKIS 186 Query: 176 FNP--------APAIADLDPQFYTLSDVFCCNESEAEILTGLTVGSA----ADAGEAALV 223 F+ A Q L D + +A ++ + A + + Sbjct: 187 FDMNYRAKLWELEAAKRAYQQLLPLVDYCSAGQMDAVAFFEISSETTDYYQAMHDKYPNI 246 Query: 224 LLKRGCQVVIITLGA---EGCVVLSQTEPEPKHIPTEKVKAVDTTGAGDSFVGALAFYLA 280 L + +I+ +G + E + + VD G GD++ A+ Sbjct: 247 ELFYATKRTVISASHHLLQGHLWTQGECWESEEYAIYPI--VDRVGGGDAYTAAVLH--G 302 Query: 281 YYPNLSLEDMLNRSNFIAAVSVQAAGTQSSYPYK 314 ++ + + A + G + + K Sbjct: 303 ILSEWRPDETVKFATAAAGLKHSIHGDINPFDEK 336 >3BF5-A nrPDB Length = 306 Score = 96.0 bits (237), Expect = 2e-20, Method: Composition-based stats. Identities = 55/294 (18%), Positives = 102/294 (34%), Gaps = 38/294 (12%) Query: 13 EEVAAVVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCVQAARLGAMTSMV 72 + + + G D++ +P+ G +++ FGG N + A + + Sbjct: 18 QGMRFLAYFGHLNIDVLISVDSIPREG-SVNVKDLRPRFGGTAGNFAIVAQKFRIPFDLY 76 Query: 73 CKVGKDSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNIIVIVAGANLLLN 132 VG + +Y+ ++ I+T + +D + I + + Q + Sbjct: 77 SAVGMKTH-REYLAMIESMGINTGHVEKFEDESGPICYIATDGKKQVSFMHQGAMAAW-- 133 Query: 133 TEDLRAAANVISRAKVMVCQLEITPATSLEALTMARRSGVKTLFNPAPAI----ADLDPQ 188 A + + + T L MA+ K +F+P+ I D + Sbjct: 134 ------APQLADEYEYVHFS------TGPNYLDMAKSIRSKIIFDPSQEIHKYSKDELKK 181 Query: 189 FYTLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLGAEGCVVLSQTE 248 F+ +S + N+ E + +T S+ I+T G G + + Sbjct: 182 FHEISYMSIFNDHEYRVFREMTGLSSPKV-------------TTIVTNGERGSSLFMDGK 228 Query: 249 PEPKHIPTEKVKAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFIAAVSV 302 P + DT GAGDSF L YLA Y S+E + IA + Sbjct: 229 K--YDFPAIP-SSGDTVGAGDSFRAGL--YLALYNRRSIEKGMIYGTIIAHHVI 277 >2Q5R-A nrPDB Length = 330 Score = 87.5 bits (215), Expect = 6e-18, Method: Composition-based stats. Identities = 45/282 (15%), Positives = 96/282 (34%), Gaps = 29/282 (10%) Query: 43 HGHKFFIGFGGKGANQCVQAARLGAMTSMVCKVGKDSFGNDYIENLKQNDISTEFTYQTK 102 + GGKG N A++G +G G + L + + + Sbjct: 47 RVQEVSKTAGGKGLNVTRVLAQVGEPVLASGFIG-GELGQFIAKKL--DHADIKHAFYNI 103 Query: 103 DAATGTASIIVNNEGQNIIV-------IVAGANLLLNTEDLRAAANVISRAKVMVCQLEI 155 T I++ Q I+ A + + E L ++ + Sbjct: 104 KGETRNCIAILHEGQQTEILEQGPEIDNQEAAGFIKHFEQLLEKVEAVA------ISGSL 157 Query: 156 TPATSLEA----LTMARRSGVKTLFNPAPAIADLDPQFYTLSDVFCCNESEAEILTGLTV 211 + + + + GV + + + A + V N SE L + Sbjct: 158 PKGLNQDYYAQIIERCQNKGVPVILDCSGATLQTVLENPYKPTVIKPNISELYQLLNQPL 217 Query: 212 GSAADAGEAA--LVLLKRGCQVVIITLGAEGCVVLSQTEPEPKHIPTEKVKAVDTTGAGD 269 + ++ + A L + G + +I++LGA+G ++ + + ++ G+GD Sbjct: 218 DESLESLKQAVSQPLFE-GIEWIIVSLGAQGAF--AKHNHTFYRVNIPTISVLNPVGSGD 274 Query: 270 SFVGALAFYLAYYPNLSLEDMLNRSNFIAAVSVQAAGTQSSY 311 S V A + + D+L ++N + ++ Q Q+ Y Sbjct: 275 STVA--GITSAILNHENDHDLLKKANTLGMLNAQE--AQTGY 312 >2AJR-A nrPDB Length = 331 Score = 84.4 bits (207), Expect = 7e-17, Method: Composition-based stats. Identities = 53/294 (18%), Positives = 105/294 (35%), Gaps = 36/294 (12%) Query: 30 SLTSRLPKTGETIHGHKFFIGFGGKGANQCVQAARLGAMTSMVCKVGKDSFGNDYIENLK 89 +RL + + K + GGKG N + ++LG + VG G +E L+ Sbjct: 32 FQVNRLYRINDL---SKTQMSPGGKGINVSIALSKLGVPSVATGFVG-GYMGKILVEELR 87 Query: 90 QNDISTEFTYQTKDAATGTASIIVNNEGQNIIVI-VAGANLL-LNTED-LRAAANVISRA 146 + + + T I++ + + I I G ++ ++ LR +S+ Sbjct: 88 KISKLITTNFVYVEGETRENIEIIDEKNKTITAINFPGPDVTDMDVNHFLRRYKMTLSKV 147 Query: 147 KVMVCQLEITPATS----LEALTMARRSGVKTLFNPAPAIADLDPQFYTLSDVFCCN-ES 201 +V I P + E + +AR GV P + + + +V + Sbjct: 148 DCVVISGSIPPGVNEGICNELVRLARERGVFVFVEQTPRLLERIYEGPEFPNVVKPDLRG 207 Query: 202 EAEILTGLTVGSAADAGEAALVLLKRGCQVVI-------ITLGAEGCVVLSQTEPEPKHI 254 G+ + + D + A L ++ V+ I EG ++ E Sbjct: 208 NHASFLGVDLKTFDDYVKLAEKLAEKSQVSVVSYEVKNDIVATREGVWLIRSKEE----- 262 Query: 255 PTEKVKAVDT---TGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFIAAVSVQAA 305 +DT GAGD++V + +Y + + +M F +A++ Sbjct: 263 -------IDTSHLLGAGDAYVAGMVYYFIKH-GANFLEMAKFG-FASALAATRR 307 >3KTN-A nrPDB Length = 346 Score = 68.3 bits (165), Expect = 4e-12, Method: Composition-based stats. Identities = 47/327 (14%), Positives = 94/327 (28%), Gaps = 46/327 (14%) Query: 17 AVVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCVQAARLGAMTSMVCKVG 76 + G M P+ + + F G G N A T+++ K+ Sbjct: 4 KIAAFGEVMLRFT-----PPEYLMLEQTEQLRMNFVGTGVNLLANLAHFQLETALITKLP 58 Query: 77 KDSFGNDYIENLKQNDISTEFTYQTKDAATGTAS-----------IIVNNEGQNIIVIVA 125 + G L++ IS ++ K G+ + N Q+ I Sbjct: 59 ANRLGEAGKAALRKLGISDQW-VGEKGDHIGSFFAEMGYGIRPTQVTYQNRHQSAFGISE 117 Query: 126 GANLLLNTEDLRAAANVISRAKVMVCQLEITPATSLEALTMARRSGVKTLFN-------- 177 + E A +++ + + E T +L A K F+ Sbjct: 118 AKDYDF--EAFLAEVDMVHICGISLSLTEKTRDAALILAQKAHAYQKKVCFDFNYRPSLN 175 Query: 178 ---PAPAIADLDPQFYTLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKR-----GC 229 A + + D+ + + L G + L++R Sbjct: 176 TANSALFMRQQYERILPYCDIVFGSRRDLVELLGFIPREDLEGEAQETELIQRFMSQYNL 235 Query: 230 QVVIITLGAEG-------CVVLSQTEPEPKHIPTEKVKAVDTTGAGDSFVGALAFYLAYY 282 + T + + +Q E + + +D GAGD++ + + Y Sbjct: 236 EWFAGTTRSHSQNQNYLSGYLYTQNE--YQQSEKRPLLNLDRIGAGDAYAAGILY--GYS 291 Query: 283 PNLSLEDMLNRSNFIAAVSVQAAGTQS 309 N SLE + + ++ G Sbjct: 292 QNWSLEKAVTFATVNGVLAHTIQGDIP 318 >5YSQ-A nrPDB Length = 286 Score = 60.9 bits (146), Expect = 7e-10, Method: Composition-based stats. Identities = 42/296 (14%), Positives = 104/296 (35%), Gaps = 23/296 (7%) Query: 28 LVSLTSRLPKTGETIHGHKFFIGFGGKGANQCVQAARLGAMTSMVCKVGKDSFGNDYIEN 87 +++ + K + G + I +GG + ++ LG T ++ K ++ Sbjct: 1 MITFIGHVSKDVNVVDGKR-EIAYGGGVVMGAITSSLLGVKTKVITKCTREDVSKF--SF 57 Query: 88 LKQNDISTEFTYQTKDAATGTASIIVNNEGQNIIVIVAGANLLLNTEDLRAAANVISRAK 147 L+ N + F + + + ++ ++ A + + A I+ Sbjct: 58 LRDNGVEVVFLKSPRTTSIENRYGSDPDTRESFLISAADPFTESDLAFIEGEAVHINPLW 117 Query: 148 VMVCQLEITPATSLEALTMARRSGVKTLFNPAPAI----ADLDPQFYTLSDVFCCNESEA 203 ++ P + + ++ + + ++ ++ D+F + EA Sbjct: 118 YGEFPEDLIPVLRRKVMFLSADAQGFVRVPENEKLVYRDWEMKEKYLKYLDLFKVDSREA 177 Query: 204 EILTGLTVGSAADAGEAALVLLKRGCQVVIITLGAEGCVVLSQT-EPEPKHIPTEKVKAV 262 E LTG D E+ ++ G ++++ T A G +V + + + Sbjct: 178 ETLTGTN-----DLRESCRIIRSFGAKIILATH-ASGVIVFDGNFYEASFRSWSLEGR-- 229 Query: 263 DTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFIAAVSVQAAGTQSSYPYKKDLP 318 TG GD+ A + +S+E + + +V ++ G ++DL Sbjct: 230 --TGRGDTCTAAFLVGF-VFKKMSIEKATKFAAAVTSVKMRHPGPL----RREDLE 278 >4S1M-A nrPDB Length = 287 Score = 58.6 bits (140), Expect = 4e-09, Method: Composition-based stats. Identities = 41/215 (19%), Positives = 75/215 (34%), Gaps = 27/215 (12%) Query: 107 GTASIIVNNEGQNIIVIVAGANLLLNT----EDLRAAANVISRAKVMVCQLEITPATSLE 162 + + +V G+ +LLN D ++ + +V + E Sbjct: 33 SIFVLTTHLANHTGYPVVGGSGVLLNDFISIMDSLEVNHLDKDIEFLVTGYFPSSDLVYE 92 Query: 163 ALTMARR--SGVKTLFNPAP------------AIADLDPQFYTLSDVFCCNESEAEILTG 208 + +R K F P + D + +D+ N +E LTG Sbjct: 93 TINRVKRIKDNKKVYFLCDPILGDNGKMYTKSEVQDSMKELIKYADIITPNATELSFLTG 152 Query: 209 LTVGSAADAGEAALVLLKRGCQVVIITLGAEG------CVVLSQTEPEPKHIPTEKVKAV 262 L V S ++A +A +L ++G V+++T EG C + I +++ Sbjct: 153 LEVNSVSEAIKACHILHEQGIPVILVTSIKEGNDIILLCSFKDTLNNKNFTIKIPRIEG- 211 Query: 263 DTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFI 297 D TG GD+ + LE +NR+ Sbjct: 212 DFTGVGDTL--TYILLSWIIKGIPLEHAVNRAIST 244 >1YGJ-A nrPDB Length = 312 Score = 55.5 bits (132), Expect = 3e-08, Method: Composition-based stats. Identities = 37/181 (20%), Positives = 66/181 (36%), Gaps = 33/181 (18%) Query: 168 RRSGVKTLFNPAPAIADLDPQFYTLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKR 227 +R+G ++ P + + ++D+ N+ EAE+LTG + S +A E +L Sbjct: 119 QRNGEGAMYVPDDLLPVYREKVVPVADIITPNQFEAELLTGRKIHSQEEALEVMDMLHSM 178 Query: 228 GCQVVII---------------------TLGAEGCVVLSQTEPEPKHIPTEKVKAVDTTG 266 G V+I T +G VV + E + V G Sbjct: 179 GPDTVVITSSNLLSPRGSDYLMALGSQRTRAPDGSVVTQRIRMEMHKVDAVFV------G 232 Query: 267 AGDSFVGALAFYLAYYPNLS---LEDMLNRSNFIAAVSVQAAGTQSS---YPYKKDLPLT 320 GD F L + +PN E ++ + + +++ A +S P L L Sbjct: 233 TGDLFAAMLLAWTHKHPNNLKVACEKTVSAMHHVLQRTIKCAKAKSGEGVKPSPAQLELR 292 Query: 321 L 321 + Sbjct: 293 M 293 >2F7K-A nrPDB Length = 327 Score = 53.6 bits (127), Expect = 1e-07, Method: Composition-based stats. Identities = 37/173 (21%), Positives = 65/173 (37%), Gaps = 21/173 (12%) Query: 170 SGVKTLFNPAPAIADLDPQFYTLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGC 229 G +++ P + + L+D+ N+ EAE+L+G + S +A +L G Sbjct: 136 DGEGSMYVPEDLLPVYKEKVVPLADIITPNQFEAELLSGRKIHSQEEALRVMDMLHSMGP 195 Query: 230 QVVIITL----GAEGCVVLSQTEPEPKHIPTEKV---------KAVDT--TGAGDSFVGA 274 V+IT +G L + + P V + VD G GD F Sbjct: 196 DTVVITSSDLPSPQGSNYLIVLGSQRRRNPAGSVVMERIRMDIRKVDAVFVGTGDLFAAM 255 Query: 275 LAFYLAYYPNLS---LEDMLNRSNFIAAVSVQAAGTQSS---YPYKKDLPLTL 321 L + +PN E ++ + + ++Q A Q+ P L L + Sbjct: 256 LLAWTHKHPNNLKVACEKTVSTLHHVLQRTIQCAKAQAGEGVRPSPMQLELRM 308 >2I5B-A nrPDB Length = 271 Score = 53.6 bits (127), Expect = 1e-07, Method: Composition-based stats. Identities = 31/124 (25%), Positives = 50/124 (40%), Gaps = 11/124 (8%) Query: 178 PAPAIADLDPQFYTLSDVFCCNESEAEILTGL-TVGSAADAGEAALVLLKRGCQVVIITL 236 L Q L+ V N EA L+G+ + + D EAA + G Q V+IT Sbjct: 120 YPEHAQALREQLAPLATVITPNLFEASQLSGMDELKTVDDMIEAAKKIHALGAQYVVITG 179 Query: 237 GAEGCVVLSQTEPEPKHIPTEKV---KAVD---TTGAGDSFVGALAFYLAYYPNLSLEDM 290 G G + + T +V + +D T GAG +F A+ LA +++ Sbjct: 180 G--GKLKHEKAVDVLYDGETAEVLESEMIDTPYTHGAGCTFSAAVTAELA--KGAEVKEA 235 Query: 291 LNRS 294 + + Sbjct: 236 IYAA 239 >4JJP-A nrPDB Length = 267 Score = 53.2 bits (126), Expect = 2e-07, Method: Composition-based stats. Identities = 41/236 (17%), Positives = 82/236 (34%), Gaps = 31/236 (13%) Query: 76 GKDSFGNDYIENLKQNDISTEFTYQTKDAATGTASII-VNNEGQNIIVIVAGANLLLNTE 134 G DS G I + + G + I + + + V N + + Sbjct: 16 GSDSSG--------GAGIQADLKTFSAIGTYGMSVITAITAQNTKGVFAVEDLNKKIIKK 67 Query: 135 DLRAAANVI--SRAKVMVCQLEITPATSLEALTMARR-SGVKTLFNP------------A 179 + A I K+ + +P LE + ++ + + +P Sbjct: 68 QIEAVFEDIPPRAVKIGMVS---SPEIILEIVENLKKYNPKYLVVDPVMISKSGYYLLKP 124 Query: 180 PAIADLDPQFYTLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLGA- 238 A +L L+ + N EAE +TG+ + + D +L+ G + V++ G Sbjct: 125 EAKENLIKYLIPLAYIITPNIPEAEEITGIKIHNVDDMKRVGEEILQLGPKFVLMKGGHL 184 Query: 239 EGCVVLSQTEPEPKHIP-TEKVKAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNR 293 +G V + +E++ +T G G + A+ YLA + + +N Sbjct: 185 DGEAVDILVGKNIFKVYKSERIDKKNTHGTGCTLSSAITSYLAL--GYEITEAVNL 238 >1TD2-A nrPDB Length = 287 Score = 46.3 bits (108), Expect = 2e-05, Method: Composition-based stats. Identities = 34/131 (25%), Positives = 48/131 (36%), Gaps = 15/131 (11%) Query: 190 YTLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLGAEGCV------V 243 SD+ N E EIL V + +A AA L+ +G Q+V++ A + Sbjct: 137 LPASDIIAPNLVELEILCEHAVNNVEEAVLAARELIAQGPQIVLVKHLARAGYSRDRFEM 196 Query: 244 LSQTEPEPKHIPTEKVK--AVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFIAA-- 299 L T E HI V G GD G L L +L++ L + AA Sbjct: 197 LLVTADEAWHISRPLVDFGMRQPVGVGDVTSGLLLVKL--LQGATLQEALE--HVTAAVY 252 Query: 300 -VSVQAAGTQS 309 + V Q Sbjct: 253 EIMVTTKAMQE 263 >2DDM-A nrPDB Length = 283 Score = 46.3 bits (108), Expect = 2e-05, Method: Composition-based stats. Identities = 28/117 (23%), Positives = 40/117 (34%), Gaps = 12/117 (10%) Query: 185 LDPQFYTLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLGAEGCVVL 244 L+ N E EILTG A AA LL + V++T A G Sbjct: 145 YRQYLLPLAQGITPNIFELEILTGKNCRDLDSAIAAAKSLLSDTLKWVVVT-SASGN--E 201 Query: 245 SQTEPEPKHIPTEKVKAV-------DTTGAGDSFVGALAFYLAYYPNLSLEDMLNRS 294 E + + + V + D G GD F L +L D ++R+ Sbjct: 202 ENQEMQVVVVTADSVNVISHSRVKTDLKGTGDLFCAQL--ISGLLKGKALTDAVHRA 256 >3PZS-A nrPDB Length = 289 Score = 45.1 bits (105), Expect = 4e-05, Method: Composition-based stats. Identities = 27/122 (22%), Positives = 43/122 (35%), Gaps = 12/122 (9%) Query: 187 PQFYTLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIIT-LGAEG----- 240 + SD+ N E E L+G V + A + A L RG +VV++ L G Sbjct: 136 NEALPASDMIAPNLLELEQLSGERVENVEQAVQVARSLCARGPKVVLVKHLSRAGYHADC 195 Query: 241 --CVVLSQTEPEPKHIPTEKVKAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFIA 298 ++++ + P G GD G + L+ L + A Sbjct: 196 FEMLLVTADDAWHICRPLVDFGKRQPVGVGDLTSG--LLLVNLLKGEPLDKALE--HVTA 251 Query: 299 AV 300 AV Sbjct: 252 AV 253 >5TQI-A nrPDB Length = 294 Score = 44.0 bits (102), Expect = 8e-05, Method: Composition-based stats. Identities = 34/182 (18%), Positives = 62/182 (34%), Gaps = 37/182 (20%) Query: 138 AAANVISRAKVMVCQLEITPATSLEALTMARRS---------------GVKTLFNPAPAI 182 AA + R ++ +PA + + + R G P P + Sbjct: 75 AAIGALKRCDAVLSGFAGSPAQARATVEIVRAVKAMNPNAWYFCDPAMGQTGGIRPEPGV 134 Query: 183 AD-LDPQFYTLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITL----- 236 + + + L+D N +E + L G + + A+A +A L+ RG +++++ Sbjct: 135 EEFIVNEMPALADGMSPNHTELQKLAGRRIETVAEAVDACRTLIARGPKIILVKHLHDRN 194 Query: 237 ---GAEGCVVLSQTE-----PEPKHIPTEKVKAVDTTGA--------GDSFVGALAFYLA 280 + +++TE P V D T A GDS A LA Sbjct: 195 SPADRFNMLAVTETEAWIGQRPLYAFPRHPVGVGDLTSAIFVARRLRGDSVRAAFEHTLA 254 Query: 281 YY 282 Sbjct: 255 AV 256 >5B6A-A nrPDB Length = 288 Score = 43.6 bits (101), Expect = 1e-04, Method: Composition-based stats. Identities = 27/159 (16%), Positives = 48/159 (30%), Gaps = 15/159 (9%) Query: 149 MVCQLEITPATSLEALTMARRSGVKTLFNPAPAIADLDPQFYTLSDVFCCNESEAEILTG 208 +V +++ +L K L + ++D C N+ E + Sbjct: 98 VVARIKQANPRALYLCDPVMGHPEKGCIVAPEVSDFLLEEAAAVADYLCPNQLELDSFCD 157 Query: 209 LTVGSAADAGEAALVLLKRGCQVVIITL----GAEG------CVVLSQTEPEPKHIPTEK 258 S AD E A LL RG + +++ G G V Q + + Sbjct: 158 RQPNSLADCVEMARSLLARGPRAILVKHLNYPGKAGDTFEMLLVAADQAWHLQRPLLAFP 217 Query: 259 VKAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFI 297 + V G GD + + F L + + Sbjct: 218 RQPV---GVGD--LASGLFLSRLLLGDDLRNAFEFTGAA 251 >1UB0-A nrPDB Length = 258 Score = 42.8 bits (99), Expect = 2e-04, Method: Composition-based stats. Identities = 27/111 (24%), Positives = 43/111 (38%), Gaps = 5/111 (4%) Query: 189 FYTLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLG---AEGCVVLS 245 + L+D+ N EAE L G + + +A EAA LL G + V++ G E V L Sbjct: 127 LFPLADLVTPNRLEAEALLGRPIRTLKEAEEAAKALLALGPKAVLLKGGHLEGEEAVDLL 186 Query: 246 QTEPEPKHIPTEKVKAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNF 296 T +V +T G G + + A L + + + Sbjct: 187 ATRGGVLRFSAPRVHTRNTHGTGCT--LSAAIAALLAKGRPLAEAVAEAKA 235 >3ZS7-A nrPDB Length = 300 Score = 42.1 bits (97), Expect = 4e-04, Method: Composition-based stats. Identities = 18/65 (27%), Positives = 27/65 (41%) Query: 171 GVKTLFNPAPAIADLDPQFYTLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQ 230 G + + D + L+D+ N EA +L+G+TV + A AA G Sbjct: 121 GDDGIMYCKKEVLDAYRELVPLADIVTPNYFEASLLSGVTVNDLSSAILAADWFHNCGVA 180 Query: 231 VVIIT 235 VII Sbjct: 181 HVIIK 185 >3MBJ-A nrPDB Length = 291 Score = 37.8 bits (86), Expect = 0.006, Method: Composition-based stats. Identities = 25/135 (18%), Positives = 44/135 (32%), Gaps = 14/135 (10%) Query: 170 SGVKTLFNPAPAIADLDPQFYTLSDVFCCNESEAEILTGLTVG---SAADAGEAALVLLK 226 +G + ++ T +DV N +E L + + E +L Sbjct: 118 NGRLYTNFDMEMVKEMRH-LITKADVITPNLTELFYLLDEPYKADSTDEELKEYLRLLSD 176 Query: 227 RGCQVVIITLGA-------EGCVVLSQTEPEPKHIPTEKVKAVDTTGAGDSFVGALAFYL 279 +G QVVIIT ++ + + A G GD+F + Sbjct: 177 KGPQVVIITSVPVHDEPHKTSVYAYNRQGNRYWKVTCPYLPAHYP-GTGDTFTSVITG-- 233 Query: 280 AYYPNLSLEDMLNRS 294 + SL L+R+ Sbjct: 234 SLMQGDSLPMALDRA 248 >4XF7-A nrPDB Length = 273 Score = 37.4 bits (85), Expect = 0.008, Method: Composition-based stats. Identities = 44/290 (15%), Positives = 84/290 (28%), Gaps = 50/290 (17%) Query: 17 AVVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCVQAARLGAMTSMVCKVG 76 +VVG + D+V G+K GG + +R ++ Sbjct: 2 KCLVVGHVVRDIVKK------------GNKVLERLGGGAYYSALALSRF-CDVEILT--- 45 Query: 77 KDSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNIIVIVAGANLLLNTEDL 136 SF N E +K+ + + + T ++ + + ++ + + + Sbjct: 46 --SFSNLPEEWIKELESMAKLQVVPSETTTTYELTYLDGNRRRLKLLERASPIEELPD-- 101 Query: 137 RAAANVISRAKVMVCQLEITPATSLEALTMARRSGVKT---LFNPAPAIADLDPQ---FY 190 + E+ PA AL V + + +P P F Sbjct: 102 ----GEYDVLLMNPVAREVPPALVTSALKKFPFVAVDIQGFIRSSSPGEIQYQPIDGSFL 157 Query: 191 TLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLGAEGCVVLSQTEPE 250 + + E + L G + V++++ G E Sbjct: 158 KGVKILHADLGEYQYLQGFSPEF---------------VDVLLLSNGPEPGKAFLHGREY 202 Query: 251 PKHIPTEKVKAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFIAAV 300 V +TGAGD F+GA +Y L R+ A+ Sbjct: 203 TFEPVHVGVDE--STGAGDVFLGAFT---GFYSQCPFVQALKRAAAFTAL 247 >3HYO-A nrPDB Length = 282 Score = 36.3 bits (82), Expect = 0.017, Method: Composition-based stats. Identities = 32/142 (22%), Positives = 49/142 (34%), Gaps = 18/142 (12%) Query: 188 QFYTLSDVFCCNESEAEILTGLTVGSAADAGEAALVL---LKRGCQVVI--ITLGAE-GC 241 Q +DV N +EA +LTG D L LK G VI + + GC Sbjct: 130 QLIQQADVILPNTTEAALLTGAPYQVTPDLEVILPALQAQLKTGAHAVITDVQRADQIGC 189 Query: 242 VVLSQTEP----EPKHIPTEKVKAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFI 297 L + + +P G GD+ +A L L L R+N Sbjct: 190 AWLDEAGHVQYCGARRLPGHY------NGTGDTLAAVIAGLLGR--GYPLAPTLARANQW 241 Query: 298 AAVSVQAAGTQSSYPYKKDLPL 319 ++V Q+ ++ + L Sbjct: 242 LNMAVAETIAQNRTDDRQGVAL 263 >4YL5-A nrPDB Length = 263 Score = 35.9 bits (81), Expect = 0.027, Method: Composition-based stats. Identities = 14/60 (23%), Positives = 24/60 (40%), Gaps = 5/60 (8%) Query: 188 QFYTLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLGAEGCVVLSQT 247 + L+ + N E LTG+T D +A L + G + V++ G E + Sbjct: 135 ELIPLATLITPNTVELRALTGVT-----DLDQATQKLFEMGAKAVLVKGGHEDTPDFIKN 189 >5MEK-A nrPDB Length = 322 Score = 35.5 bits (80), Expect = 0.034, Method: Composition-based stats. Identities = 18/101 (17%), Positives = 37/101 (36%), Gaps = 3/101 (2%) Query: 146 AKVMVCQLEITPATSLEALTMARRSGVKTLFNPAPAIADLDPQFYTLSDVFCCNESEAEI 205 + +VC T T L+ALT A + + + P + +F ++ E ++ Sbjct: 59 SDFLVCSYPKTGTTWLKALTFAIANRSRFDDSSNPLLKRNPHEFVPYIEIDFPFFPEVDV 118 Query: 206 LT---GLTVGSAADAGEAALVLLKRGCQVVIITLGAEGCVV 243 L + ++K GC++V I + + Sbjct: 119 LKDKGNTLFSTHIPYELLPDSVVKSGCKMVYIWREPKDTFI 159 >5ZWB-B nrPDB Length = 296 Score = 35.1 bits (79), Expect = 0.044, Method: Composition-based stats. Identities = 24/121 (19%), Positives = 36/121 (29%), Gaps = 7/121 (5%) Query: 179 APAIADLDPQFYTLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLGA 238 A + N E E+L+G + +A AA LL + V+IT Sbjct: 144 AEIPQAYRTHLLPQAQGLTPNVFELEMLSGKPCRTLEEAVAAAQSLLSDTLKWVVITSAP 203 Query: 239 EGCV----VLSQTEPEPKHIPTEKVKAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRS 294 + V T + +V A + G GD F L L + Sbjct: 204 GESLETITVAVVTAQVVEVFAHPRV-ATELKGTGDLFCAELV--SGIVQGKKLTTAAKDA 260 Query: 295 N 295 Sbjct: 261 A 261 >4I8O-A nrPDB Length = 358 Score = 32.4 bits (72), Expect = 0.29, Method: Composition-based stats. Identities = 12/55 (21%), Positives = 17/55 (30%) Query: 94 STEFTYQTKDAATGTASIIVNNEGQNIIVIVAGANLLLNTEDLRAAANVISRAKV 148 + T I N +G I + GAN L E I+ A+ Sbjct: 44 GLRVVFTRPGVNLATVDIFYNGDGSTTIQYLTGANRSLGQELADHLFETINPAEF 98 >3CGD-A nrPDB Length = 480 Score = 32.1 bits (71), Expect = 0.38, Method: Composition-based stats. Identities = 39/204 (19%), Positives = 66/204 (32%), Gaps = 26/204 (12%) Query: 83 DYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNIIVIVAGANLLLNTEDLRAAANV 142 Y E+ K D+ EF+Y ATG ++ EG+++ + LL D Sbjct: 126 VYAEHTKTKDV-FEFSYDRLLIATGVRPVMPEWEGRDLQGVH----LLKTIPDAERILKT 180 Query: 143 ISRAKVMVCQLEITPATSLEALTMARRSGVKTLFNPAPAI------ADLDPQFYTLSDVF 196 + KV + A LE G K D+ Y +D Sbjct: 181 LETNKVEDVTIIGGGAIGLEMAETFVELGKKVRMIERNDHIGTIYDGDMAEYIYKEAD-- 238 Query: 197 CCNESEAEILTGLTVGSAADAGEAALVLLKRG---CQVVIITLGAE-------GCVVLSQ 246 + EILT V + V +G +V++++G + G + + Sbjct: 239 ---KHHIEILTNENVKAFKGNERVEAVETDKGTYKADLVLVSVGVKPNTDFLEGTNIRTN 295 Query: 247 TEPEPKHIPTEKVKAVDTTGAGDS 270 + + + D AGD Sbjct: 296 HKGAIEVNAYMQTNVQDVYAAGDC 319 >6CY1-A nrPDB Length = 329 Score = 30.1 bits (66), Expect = 1.2, Method: Composition-based stats. Identities = 35/181 (19%), Positives = 65/181 (35%), Gaps = 6/181 (3%) Query: 140 ANVISRAKVMVCQLEITPATSLEALTMARRSGVKTLFNPAPAIADLDPQFYTLSDVFCCN 199 + +SRA V +++ LE + +A GV+T I + + +V N Sbjct: 37 FDKVSRAVVGKSKVDDEVLDDLEEVLIASDVGVETTVKIIRRIEERVAR-DKYVNVAELN 95 Query: 200 ESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLGAEGCVVLSQTEPEPKHIPTEKV 259 E ++GL + + + K VI+ +G G + +E + Sbjct: 96 NILREEISGLLLE---NPHAGTQNIDKTKKPYVIMVVGVNGVGKTTTIGKLAHQFKSEGL 152 Query: 260 KAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFIAAVSVQAAGTQSSYPYKKDLPL 319 K V GA D+F A L + ++ ++ SV QS+ D+ + Sbjct: 153 KVV--LGAADTFRAAAVDQLVIWSERVGVPIVKQAMGSDPASVAFDTVQSAVSQDADVVI 210 Query: 320 T 320 Sbjct: 211 I 211 >1J08-A nrPDB Length = 226 Score = 29.7 bits (65), Expect = 1.6, Method: Composition-based stats. Identities = 18/111 (16%), Positives = 26/111 (23%), Gaps = 6/111 (5%) Query: 165 TMARRSGVKTLFNPAPAIADLDPQFYTLSDVFCCNESEAEILTGLTVGSAADAG-----E 219 + + + NP I + + D E LT D E Sbjct: 10 RIIKEEFFSKMVNPVKLIVFIGKEHCQYCDQLKQLVQELSELTDKLSYEIVDFDTPEGKE 69 Query: 220 AALVLLKRGCQVVIITLGAEGCVVLSQTEPEPKHIPTEKVKAVDTTGAGDS 270 A IT + V P VD + GD+ Sbjct: 70 LAEKYRIDRAPATTITQDGKDFGVRYFGIPAGHEFAAFLEDIVDVS-KGDT 119 >1BJ4-A nrPDB Length = 470 Score = 28.6 bits (62), Expect = 3.8, Method: Composition-based stats. Identities = 18/132 (13%), Positives = 37/132 (28%), Gaps = 18/132 (13%) Query: 49 IGFGGKGANQCVQAARLGAMTSMVCKVGKDSFGNDYIENLKQNDISTEFTYQTKDAATGT 108 + G AN V A + + G +L T K + T Sbjct: 106 QPYSGSPANFAVYTALV------------EPHGRIMGLDLPDGGHLTHGFMTDKKKISAT 153 Query: 109 ASIIVNNEGQNIIVIVAGANLLLNTEDLRAAANVISRAKVMVCQLEITPATSLEALT-MA 167 + +++ V +N + L A + ++ + L +A Sbjct: 154 SIFF-----ESMPYKVNPDTGYINYDQLEENARLFHPKLIIAGTSCYSRNLEYARLRKIA 208 Query: 168 RRSGVKTLFNPA 179 +G + + A Sbjct: 209 DENGAYLMADMA 220 >1OXJ-A nrPDB Length = 173 Score = 28.2 bits (61), Expect = 5.5, Method: Composition-based stats. Identities = 18/94 (19%), Positives = 45/94 (47%), Gaps = 2/94 (2%) Query: 106 TGTASIIVNNEGQNIIVIVAGANLLLN--TEDLRAAANVISRAKVMVCQLEITPATSLEA 163 T +++ + + + GA+ L + L+ AN+++R + + ++ +T++E Sbjct: 30 TYEEMLLITEDFLQSVGVTKGASHKLALCIDKLKERANILNRVEQELLSGQMELSTAVEE 89 Query: 164 LTMARRSGVKTLFNPAPAIADLDPQFYTLSDVFC 197 LT + +K L +P P ++ +F + D+ Sbjct: 90 LTNIVLTPMKPLESPGPPEENIGLRFLKVIDIVT 123 >4EVZ-A nrPDB Length = 258 Score = 27.4 bits (59), Expect = 9.5, Method: Composition-based stats. Identities = 29/193 (15%), Positives = 62/193 (32%), Gaps = 11/193 (5%) Query: 113 VNNEGQNIIVIVAGANLLLNTEDLRAAANVISRAKVMVCQLEITPATSLEALTMARRSGV 172 + EG + +V + E + + + + + +A + R Sbjct: 39 YDEEGADELVFLDITASHEGRETMLEVVERTAEQVFIPLTVGGGIRSVEDASRLLRAGAD 98 Query: 173 KTLFNPA-----PAIADLDPQFYTLSDVFCCNESEA----EILT-GLTVGSAADAGEAAL 222 K N A I + +F + + V + E+ T G + DA E A Sbjct: 99 KVSINTAAVKNPELITEAAEEFGSQAVVVAIDAKRVGGGWEVFTHGGRKPTGLDAVEWAR 158 Query: 223 VLLKRGC-QVVIITLGAEGCVVLSQTEPEPKHIPTEKVKAVDTTGAGDSFVGALAFYLAY 281 +++ G ++++ ++ +G E V + + GAG+ A F L Sbjct: 159 KVVELGAGEILLTSMDRDGTKAGYDLELTRAVSEAVSVPVIASGGAGELEHFAEVFELEG 218 Query: 282 YPNLSLEDMLNRS 294 + + Sbjct: 219 ADAALAASIFHFG 231 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.306 0.125 0.304 Lambda K H 0.267 0.0389 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 9,895,886 Number of Sequences: 36641 Number of extensions: 343091 Number of successful extensions: 1548 Number of sequences better than 10.0: 84 Number of HSP's better than 10.0 without gapping: 108 Number of HSP's successfully gapped in prelim test: 38 Number of HSP's that attempted gapping in prelim test: 1188 Number of HSP's gapped (non-prelim): 161 length of query: 322 length of database: 10,336,785 effective HSP length: 97 effective length of query: 225 effective length of database: 6,782,608 effective search space: 1526086800 effective search space used: 1526086800 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.1 bits) S2: 59 (27.4 bits)