BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q9GZT4 (340 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 5X2L-A nrPDB 697 0.0 3L6C-A nrPDB 598 e-172 5CVC-A nrPDB 265 2e-71 5YBW-A nrPDB 233 9e-62 1V71-A nrPDB 203 9e-53 1VE5-A nrPDB 191 4e-49 2GN1-A nrPDB 144 6e-35 3IAU-A nrPDB 134 8e-32 1TDJ-A nrPDB 115 4e-26 5JJC-A nrPDB 78 4e-15 1PWH-A nrPDB 71 7e-13 1M54-A nrPDB 67 8e-12 4COO-A nrPDB 67 1e-11 5MMS-A nrPDB 67 2e-11 6NMX-A nrPDB 64 1e-10 2D1F-A nrPDB 61 8e-10 4H27-A nrPDB 59 3e-09 3PC3-A nrPDB 56 2e-08 3FCA-A nrPDB 56 2e-08 5I7O-A nrPDB 54 9e-08 5D84-A nrPDB 54 1e-07 2RKB-A nrPDB 53 2e-07 5C3U-A nrPDB 52 4e-07 5B1I-A nrPDB 51 6e-07 6C2H-A nrPDB 51 8e-07 5OHX-A nrPDB 51 8e-07 2ZSJ-A nrPDB 49 2e-06 2PQM-A nrPDB 48 5e-06 2JC3-A nrPDB 48 8e-06 4OFX-A nrPDB 47 1e-05 5YGR-A nrPDB 47 1e-05 2EFY-A nrPDB 46 2e-05 2BHS-A nrPDB 46 3e-05 1UIN-A nrPDB 46 3e-05 2Q3D-A nrPDB 45 4e-05 5B55-A nrPDB 44 1e-04 5XW3-A nrPDB 43 2e-04 2EGU-A nrPDB 42 4e-04 4I1Y-A nrPDB 41 7e-04 3VBE-A nrPDB 41 7e-04 3X43-A nrPDB 41 0.001 6AHI-A nrPDB 40 0.001 5XCN-X nrPDB 39 0.003 2ISQ-A nrPDB 36 0.026 5J5V-A nrPDB 36 0.027 4D9G-A nrPDB 35 0.033 5XEM-A nrPDB 35 0.045 4LMA-A nrPDB 34 0.071 5EY5-B nrPDB 33 0.13 5XA2-A nrPDB 33 0.16 4LMB-A nrPDB 32 0.40 4AEC-A nrPDB 32 0.49 1X1Q-A nrPDB 32 0.54 5KIN-B nrPDB 31 0.85 3JYN-A nrPDB 30 1.3 4ZW2-A nrPDB 30 1.6 5BPF-A nrPDB 30 1.8 3T4P-A nrPDB 29 2.6 5OCW-B nrPDB 29 2.6 4L16-A nrPDB 28 5.1 1VQ2-A nrPDB 28 5.5 1J0B-A nrPDB 28 6.7 3IYS-A nrPDB 28 7.0 4D9F-A nrPDB 27 9.7 >5X2L-A nrPDB Length = 348 Score = 697 bits (1800), Expect = 0.0, Method: Compositional matrix adjust. Identities = 340/340 (100%), Positives = 340/340 (100%) Query: 1 MCAQYCISFADVEKAHINIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGA 60 MCAQYCISFADVEKAHINIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGA Sbjct: 1 MCAQYCISFADVEKAHINIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGA 60 Query: 61 LNAVRSLVPDALERKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQA 120 LNAVRSLVPDALERKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQA Sbjct: 61 LNAVRSLVPDALERKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQA 120 Query: 121 YGASIVYCEPSDESRENVAKRVTEETEGIMVHPNQEPAVIAGQGTIALEVLNQVPLVDAL 180 YGASIVYCEPSDESRENVAKRVTEETEGIMVHPNQEPAVIAGQGTIALEVLNQVPLVDAL Sbjct: 121 YGASIVYCEPSDESRENVAKRVTEETEGIMVHPNQEPAVIAGQGTIALEVLNQVPLVDAL 180 Query: 181 VVPVGGGGMLAGIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGV 240 VVPVGGGGMLAGIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGV Sbjct: 181 VVPVGGGGMLAGIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGV 240 Query: 241 KSSIGLNTWPIIRDLVDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQT 300 KSSIGLNTWPIIRDLVDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQT Sbjct: 241 KSSIGLNTWPIIRDLVDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQT 300 Query: 301 VSPEVKNICIVLSGGNVDLTSSITWVKQAERPASYQSVSV 340 VSPEVKNICIVLSGGNVDLTSSITWVKQAERPASYQSVSV Sbjct: 301 VSPEVKNICIVLSGGNVDLTSSITWVKQAERPASYQSVSV 340 >3L6C-A nrPDB Length = 339 Score = 598 bits (1543), Expect = e-172, Method: Compositional matrix adjust. Identities = 302/333 (90%), Positives = 321/333 (96%), Gaps = 1/333 (0%) Query: 1 MCAQYCISFADVEKAHINIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGA 60 M AQY ISFADVEKAH+NI+DS+HLTPVLTSSILNQ+ GRNLFFKCELFQKTGSFKIRGA Sbjct: 1 MDAQYDISFADVEKAHLNIQDSVHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGA 60 Query: 61 LNAVRSLVPDALERKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQA 120 LNA+R L+PD LE KPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAP+CKKLAIQA Sbjct: 61 LNAIRGLIPDTLEGKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPNCKKLAIQA 120 Query: 121 YGASIVYCEPSDESRENVAKRVTEETEGIMVHPNQEPAVIAGQGTIALEVLNQVPLVDAL 180 YGASIVY EPSDESRENVA+R+ +ETEGI+VHPNQEPAVIAGQGTIALEVLNQVPLVDAL Sbjct: 121 YGASIVYSEPSDESRENVAQRIIQETEGILVHPNQEPAVIAGQGTIALEVLNQVPLVDAL 180 Query: 181 VVPVGGGGMLAGIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGV 240 VVPVGGGGM+AGIAIT+K LKPSVKVYAAEPSNADDCYQSKLKG+L PNL+PPETIADGV Sbjct: 181 VVPVGGGGMVAGIAITIKTLKPSVKVYAAEPSNADDCYQSKLKGELTPNLHPPETIADGV 240 Query: 241 KSSIGLNTWPIIRDLVDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQT 300 KSSIGLNTWPIIRDLVDD+FTVTEDEIK ATQLVWERMKLLIEPTAGVG+AAVLSQHFQT Sbjct: 241 KSSIGLNTWPIIRDLVDDVFTVTEDEIKYATQLVWERMKLLIEPTAGVGLAAVLSQHFQT 300 Query: 301 VSPEVKNICIVLSGGNVDLTSSITWVKQAERPA 333 VSPEVKNICIVLSGGNVDLT S++WVKQAERPA Sbjct: 301 VSPEVKNICIVLSGGNVDLT-SLSWVKQAERPA 332 >5CVC-A nrPDB Length = 346 Score = 265 bits (678), Expect = 2e-71, Method: Compositional matrix adjust. Identities = 145/317 (45%), Positives = 212/317 (66%), Gaps = 6/317 (1%) Query: 5 YCISFADVEKAHINIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAV 64 Y + +A I +H TPV++S+ ++ + G+ LFFKCE FQK G+FKIRGA N++ Sbjct: 16 YAADIDSIREAQARIAPYVHRTPVMSSTSIDAMVGKKLFFKCECFQKAGAFKIRGASNSI 75 Query: 65 RSLVPDALERKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGAS 124 +L E+ K VVTHSSGNH A+ AAKL GIPA+IV+P+ AP K ++ YG Sbjct: 76 FALDD---EQVSKGVVTHSSGNHAAAVALAAKLRGIPAHIVIPRNAPASKVENVKCYGGH 132 Query: 125 IVYCEPSDESRENVAKRVTEETEGIMVHPNQEPAVIAGQGTIALEVLNQVPLVDALVVPV 184 I++ + S ESRE V+KRV EET +++HP I+GQGT++LE+L QVP +D ++VP+ Sbjct: 133 IIWSDASIESREYVSKRVQEETGAVLIHPINSKYTISGQGTVSLELLEQVPEIDTIIVPI 192 Query: 185 GGGGMLAGIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGVKSSI 244 GGG+++G+A+ KA+ PS+++ AAEP ADD QSK GK++ L TIADG+++ + Sbjct: 193 SGGGLISGVALAAKAINPSIRILAAEPKGADDSAQSKAAGKII-TLPSTNTIADGLRAFL 251 Query: 245 GLNTWPIIRDLVDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQTVSP- 303 G TWP++RDLVDD+ V + I A ++ +E +K+ +EP+ +G+AA LS F+ S Sbjct: 252 GDLTWPVVRDLVDDVIVVDDTAIVDAMKMCYEILKVAVEPSGAIGLAAALSDEFKQSSAW 311 Query: 304 -EVKNICIVLSGGNVDL 319 E I I++SGGNVDL Sbjct: 312 HESSKIGIIVSGGNVDL 328 >5YBW-A nrPDB Length = 329 Score = 233 bits (594), Expect = 9e-62, Method: Compositional matrix adjust. Identities = 143/329 (43%), Positives = 198/329 (60%), Gaps = 21/329 (6%) Query: 4 QYCISFADVEKAHINIRDSIHLTPVLTSSILNQL----TGRNLFFKCELFQKTGSFKIRG 59 Q+ ++ D++KA+ I I TPV TS +++ GR +FK E QKTGSFK RG Sbjct: 3 QFEVTVTDIKKAYDRISKHILYTPVFTSPTFDRMVGSKAGRQFYFKAENLQKTGSFKARG 62 Query: 60 ALNAVRSLVPDALERKPK--AVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLA 117 ALNA+ ALER+P VVTHSSGNHGQAL +A+K G+ +VVP+TAP K A Sbjct: 63 ALNAILC----ALEREPSLAGVVTHSSGNHGQALAWASKRAGVKCCVVVPKTAPQVKFDA 118 Query: 118 IQAYGASIVYCEPSDESRENVAKRVTEETEGIMVHPNQEPAVIAGQGTIALEVLNQVPLV 177 ++ YGA +V CEP+ SR+ + + + + + + VIAGQGTIALE+L Q P + Sbjct: 119 MENYGAEVVKCEPNPTSRKETCEGLAKSRGYKYISSSDDYDVIAGQGTIALELLQQQPDL 178 Query: 178 DALVVPVGGGGMLAGIAITVKALKPSVKVYAAEPSNA--DDCYQSKLKGKLMPNLYPPE- 234 DA++V V GGM +GI + K K +KV+ EP ++C + +L PN PP+ Sbjct: 179 DAILVSVSAGGMASGICVYTKNTKSDLKVFLVEPEGKMLEECISK--RERLWPN--PPQF 234 Query: 235 --TIADG-VKSSIGLNTWPIIRDLVD-DIFTVTEDEIKCATQLVWERMKLLIEPTAGVGV 290 TIADG + G TWPII +L + ++ TV D I A + V+ RMKL+IE AG V Sbjct: 235 LDTIADGIILQQCGNKTWPIILELPEKEVITVNNDNIVEAMRFVFARMKLVIEAAAGATV 294 Query: 291 AAVLSQHFQTVSPEVKNICIVLSGGNVDL 319 AA +++ FQ PE K + I+L GGNVD+ Sbjct: 295 AAAMTERFQNFHPEAKKVGIILCGGNVDI 323 >1V71-A nrPDB Length = 323 Score = 203 bits (516), Expect = 9e-53, Method: Compositional matrix adjust. Identities = 128/324 (39%), Positives = 197/324 (60%), Gaps = 12/324 (3%) Query: 8 SFADVEKAHINIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVRSL 67 ++ DV A I+ + TPVLTSS +N+ +FFKCE FQK G+FK RGALNA+ L Sbjct: 9 TYDDVASASERIKKFANKTPVLTSSTVNKEFVAEVFFKCENFQKMGAFKFRGALNALSQL 68 Query: 68 VPDALERKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVY 127 + +RK V+T SSGNH QA+ +AK+ GIPA I++P AP+ K A + YG ++ Sbjct: 69 --NEAQRKA-GVLTFSSGNHAQAIALSAKILGIPAKIIMPLDAPEAKVAATKGYGGQVIM 125 Query: 128 CEPSDESRENVAKRVTEETEGIMVHPNQEPAVIAGQGTIALEVLNQVPLVDALVVPVGGG 187 + + RE +AK ++E ++ P P V+AGQGT A E+ +V +DAL V +GGG Sbjct: 126 YDRYKDDREKMAKEISEREGLTIIPPYDHPHVLAGQGTAAKELFEEVGPLDALFVCLGGG 185 Query: 188 GMLAGIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGVKSS-IGL 246 G+L+G A+ + P+ +VY EP +D QS KG ++ ++ P+TIADG ++ +G Sbjct: 186 GLLSGSALAARHFAPNCEVYGVEPEAGNDGQQSFRKGSIV-HIDTPKTIADGAQTQHLGN 244 Query: 247 NTWPIIRDLVDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQTVSPEVK 306 T+ II++ VDDI TV+++E+ + RMK+++EPT + AA + + ++K Sbjct: 245 YTFSIIKEKVDDILTVSDEELIDCLKFYAARMKIVVEPTGCLSFAAA-----RAMKEKLK 299 Query: 307 N--ICIVLSGGNVDLTSSITWVKQ 328 N I I++SGGNVD+ ++ Q Sbjct: 300 NKRIGIIISGGNVDIERYAHFLSQ 323 >1VE5-A nrPDB Length = 311 Score = 191 bits (485), Expect = 4e-49, Method: Compositional matrix adjust. Identities = 133/318 (41%), Positives = 193/318 (60%), Gaps = 15/318 (4%) Query: 8 SFADVEKAHINIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVRSL 67 S D+ A I H TP+LTS +L+ L G+ L K E QKTGSFK RGAL+ +L Sbjct: 3 SLQDLYAAFRRIAPYTHRTPLLTSRLLDGLLGKRLLLKAEHLQKTGSFKARGALSKALAL 62 Query: 68 VPDALERKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVY 127 PK ++ SSGNH Q + YAA++ G+ A +V+P+ A KK +AYGA +V Sbjct: 63 ------ENPKGLLAVSSGNHAQGVAYAAQVLGVKALVVMPEDASPYKKACARAYGAEVVD 116 Query: 128 CEPSDESRENVAKRVTEETEGIMVHPNQEPAVIAGQGTIALEVLNQVPLV----DALVVP 183 + ++RE VA+ + EET ++HP +P VIAGQGT LE+L Q + A++ P Sbjct: 117 RGVTAKNREEVARALQEETGYALIHPFDDPLVIAGQGTAGLELLAQAGRMGVFPGAVLAP 176 Query: 184 VGGGGMLAGIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGVKS- 242 VGGGG+LAG+A VKAL P+ V EP ADD +S G+++ PP T ADGV++ Sbjct: 177 VGGGGLLAGLATAVKALSPTTLVLGVEPEAADDAKRSLEAGRILRLEAPPRTRADGVRTL 236 Query: 243 SIGLNTWPIIRDLVDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQTVS 302 S+G T+PI+R+ VD I TV+E+ + A +L++ R K ++EPT + +AAVL +H + Sbjct: 237 SLGERTFPILRERVDGILTVSEEALLEAERLLFTRTKQVVEPTGALPLAAVL-EHGARLP 295 Query: 303 PEVKNICIVLSGGNVDLT 320 + + ++LSGGN D + Sbjct: 296 ---QTLALLLSGGNRDFS 310 >2GN1-A nrPDB Length = 342 Score = 144 bits (363), Expect = 6e-35, Method: Compositional matrix adjust. Identities = 121/329 (36%), Positives = 184/329 (55%), Gaps = 14/329 (4%) Query: 7 ISFADVEKAHINIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVRS 66 ++ D+ +A + I+ T + S+ ++ +F K E Q+TGSFKIRGA N + S Sbjct: 22 VAIEDILEAKKRLAGKIYKTGMPRSNYFSERCKGEIFLKFENMQRTGSFKIRGAFNKLSS 81 Query: 67 LVPDALERKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIV 126 L K K VV S+GNH Q ++ + + GI +V+P+ AP K A Y A +V Sbjct: 82 LTE---AEKRKGVVACSAGNHAQGVSLSCAMLGIDGKVVMPKGAPKSKVAATCDYSAEVV 138 Query: 127 YCEPSDESRENVAKRVTE--ETEG-IMVHPNQEPAVIAGQGTIALEVLNQVPLVDALVVP 183 D + +AK V+E ETEG I + P +P VIAGQGTI LE++ + VD ++VP Sbjct: 139 L--HGDNFNDTIAK-VSEIVETEGRIFIPPYDDPKVIAGQGTIGLEIMEDLYDVDNVIVP 195 Query: 184 VGGGGMLAGIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGVK-S 242 +GGGG++AGIAI +K++ P++KV + N S G++ + T+ADG S Sbjct: 196 IGGGGLIAGIAIAIKSINPTIKVIGVQAENVHGMAASYYTGEITTH-RTTGTLADGCDVS 254 Query: 243 SIGLNTWPIIRDLVDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQTVS 302 G T+ I+R+LVDDI V+EDEI+ + + +R K++ E + AA+LS + Sbjct: 255 RPGNLTYEIVRELVDDIVLVSEDEIRNSMIALIQRNKVITEGAGALACAALLSGKLDSHI 314 Query: 303 PEVKNICIVLSGGNVDLT--SSITWVKQA 329 K + I+ SGGN+DL+ S IT + A Sbjct: 315 QNRKTVSII-SGGNIDLSRVSQITGLVDA 342 >3IAU-A nrPDB Length = 366 Score = 134 bits (336), Expect = 8e-32, Method: Compositional matrix adjust. Identities = 95/297 (31%), Positives = 159/297 (53%), Gaps = 8/297 (2%) Query: 26 TPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVRSLVPDALERKPKAVVTHSSG 85 +P+ + L+ G N + K E Q+ SFK+RGA N + +L + L+ K V+T S+G Sbjct: 61 SPLELAEKLSDRLGVNFYIKREDKQRVFSFKLRGAYNMMSNLSREELD---KGVITASAG 117 Query: 86 NHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIV-YCEPSDESRENVAKRVTE 144 NH Q + A + A IV+P T P K A++A G +V Y + DE++ + A ++E Sbjct: 118 NHAQGVALAGQRLNCVAKIVMPTTTPQIKIDAVRALGGDVVLYGKTFDEAQTH-ALELSE 176 Query: 145 ETEGIMVHPNQEPAVIAGQGTIALEVLNQVPLVDALVVPVGGGGMLAGIAITVKALKPSV 204 + + P +P VI GQGTI E+ Q+ + A+ +PVGGGG++AG+A K + P+ Sbjct: 177 KDGLKYIPPFDDPGVIKGQGTIGTEINRQLKDIHAVFIPVGGGGLIAGVATFFKQIAPNT 236 Query: 205 KVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGVKSS-IGLNTWPIIRDLVDDIFTVT 263 K+ EP A S +G + L +T ADGV + +G T+ ++L+D + V Sbjct: 237 KIIGVEPYGAASMTLSLHEGHRV-KLSNVDTFADGVAVALVGEYTFAKCQELIDGMVLVA 295 Query: 264 EDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQTVSPEVKNICIVLSGGNVDLT 320 D I A + V++ + ++E T+G A + + + + +NI + SG N+D + Sbjct: 296 NDGISAAIKDVYDEGRNILE-TSGAVAIAGAAAYCEFYKIKNENIVAIASGANMDFS 351 >1TDJ-A nrPDB Length = 514 Score = 115 bits (287), Expect = 4e-26, Method: Compositional matrix adjust. Identities = 91/302 (30%), Positives = 158/302 (52%), Gaps = 6/302 (1%) Query: 19 IRDSIHLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVRSLVPDALERKPKA 78 + ++ +TP+ L+ + K E Q SFK+RGA + L E+K Sbjct: 25 VYEAAQVTPLQKMEKLSSRLDNVILVKREDRQPVHSFKLRGAYAMMAGLTE---EQKAHG 81 Query: 79 VVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYCEPSDESRENV 138 V+T S+GNH Q + +++ G+ A IV+P D K A++ +G ++ + + + Sbjct: 82 VITASAGNHAQGVAFSSARLGVKALIVMPTATADIKVDAVRGFGGEVLLHGANFDEAKAK 141 Query: 139 AKRVTEETEGIMVHPNQEPAVIAGQGTIALEVLNQVPLVDALVVPVGGGGMLAGIAITVK 198 A ++++ V P P VIAGQGT+ALE+L Q +D + VPVGGGG+ AG+A+ +K Sbjct: 142 AIELSQQQGFTWVPPFDHPMVIAGQGTLALELLQQDAHLDRVFVPVGGGGLAAGVAVLIK 201 Query: 199 ALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGVK-SSIGLNTWPIIRDLVD 257 L P +KV A E ++ C ++ L +L A+GV IG T+ + ++ +D Sbjct: 202 QLMPQIKVIAVEAEDS-ACLKAALDAGHPVDLPRVGLFAEGVAVKRIGDETFRLCQEYLD 260 Query: 258 DIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQTVSPEVKNICIVLSGGNV 317 DI TV D I A + ++E ++ + EP+ + +A + ++ + + + +LSG NV Sbjct: 261 DIITVDSDAICAAMKDLFEDVRAVAEPSGALALAG-MKKYIALHNIRGERLAHILSGANV 319 Query: 318 DL 319 + Sbjct: 320 NF 321 >5JJC-A nrPDB Length = 342 Score = 78.2 bits (191), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 63/209 (30%), Positives = 99/209 (47%), Gaps = 12/209 (5%) Query: 18 NIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVRSLVPDALERKPK 77 ++ D+I TP++ S ++LTG +++ K E S K R AL +R L R Sbjct: 4 SVLDTIGNTPLIRLSKASELTGCDIYGKAEFLNPGQSVKDRAALYIIRDAEKRGLLRPGG 63 Query: 78 AVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIV------YCEPS 131 +V ++GN G LT AK G IV+P+TA KK A++ GA ++ Y P+ Sbjct: 64 VIVEGTAGNTGIGLTMVAKALGYRTAIVIPETASQEKKDALRLLGAELIEVPAAPYRNPN 123 Query: 132 DESR--ENVAKRVTEETEGIMVHPNQEPAVIAGQG---TIALEVLNQVP-LVDALVVPVG 185 + R +A+++ + + NQ + Q T A E+ +D V VG Sbjct: 124 NAVRLSGRLAEQLAKTEPNGAIWANQFDNTVNRQAHIETTAQEIWRDTSDQIDGFVAAVG 183 Query: 186 GGGMLAGIAITVKALKPSVKVYAAEPSNA 214 GG LAG AI +K ++K+ A+P A Sbjct: 184 SGGTLAGTAIGLKERNHNIKIALADPHGA 212 >1PWH-A nrPDB Length = 327 Score = 70.9 bits (172), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 87/327 (26%), Positives = 147/327 (44%), Gaps = 47/327 (14%) Query: 20 RDSIHL-TPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVRSLVPDALERKPKA 78 ++S+H+ TP+ S L+++ G ++F K + Q +GSFKIRG + L ++ K Sbjct: 4 QESLHVKTPLRDSMALSKVAGTSVFLKMDSSQPSGSFKIRG----IGHLCKMKAKQGCKH 59 Query: 79 VVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASI-VYCEPSDESREN 137 V S+GN G A YAA+ G+PA IVVP T P ++ GA++ V E DE+ + Sbjct: 60 FVCSSAGNAGMATAYAARRLGLPATIVVPSTTPALTIERLKNEGATVEVVGEMLDEAIQ- 118 Query: 138 VAKRVTEETEG-IMVHPNQEPAVIAGQGTIALEVLNQVPLVDALVVPVGGGGMLAGIAIT 196 +AK + + G + + P +P + G ++ E+ + +V G + Sbjct: 119 LAKALEKNNPGWVYISPFDDPLIWEGHTSLVKELKETLSAKPGAIVLS--VGGGGLLCGV 176 Query: 197 VKALK----PSVKVYAAEPSNADDCYQSKLKGKL--MPNLYPPETIADGVKSSIGLNT-- 248 V+ L+ V + A E A + + +GKL +P + V ++G+NT Sbjct: 177 VQGLREVGWEDVPIIAMETFGAHSFHAAVKEGKLVTLPKI-------TSVAKALGVNTVG 229 Query: 249 ---------WPIIRDLVDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAV------ 293 PI +++ D VT A + + K+L+EP G +AAV Sbjct: 230 AQTLKLFYEHPIFSEVISDQEAVT------AIEKFVDDEKILVEPACGAALAAVYSGVVC 283 Query: 294 -LSQHFQTVSPEVKNICIVLSGGNVDL 319 L + +P + IV G N+ L Sbjct: 284 RLQAEARLQTPLASLVVIVCGGSNISL 310 >1M54-A nrPDB Length = 363 Score = 67.4 bits (163), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 75/275 (27%), Positives = 112/275 (40%), Gaps = 31/275 (11%) Query: 42 LFFKCELFQKTGSFKIRGALNAVRSLVPDALERKPKAVVTHSSGNHGQALTYAAKLEGIP 101 L KCE F GS K R +L + D + ++ +SGN G L AA + G Sbjct: 62 LLAKCEFFNAGGSVKDRISLRMIEDAERDGTLKPGDTIIEPTSGNTGIGLALAAAVRGYR 121 Query: 102 AYIVVPQTAPDCKKLAIQAYGASIVYCE-----PSDESRENVAKRVTEE--TEGIMVHPN 154 IV+P+ K ++A GA IV S ES VA R+ E I+ Sbjct: 122 CIIVMPEKMSSEKVDVLRALGAEIVRTPTNARFDSPESHVGVAWRLKNEIPNSHILDQYR 181 Query: 155 QEPAVIAGQGTIALEVLNQVP-LVDALVVPVGGGGMLAGIAITVKALKPSVKVYAAEPSN 213 +A T A E+L Q +D LV VG GG + GIA +K P ++ +P Sbjct: 182 NASNPLAHYDTTADEILQQCDGKLDMLVASVGTGGTITGIARKLKEKCPGCRIIGVDPEG 241 Query: 214 ADDCYQSKLKGKLMPNLYPPETIADGVKSS-----IGLNTWPII--RDLVDDIFTVTEDE 266 + L PE + +++ IG + P + R +VD F ++E Sbjct: 242 S--------------ILAEPEELNQTEQTTYEVEGIGYDFIPTVLDRTVVDKWFKSNDEE 287 Query: 267 IKCATQLVWERMKLLIEPTAG--VGVAAVLSQHFQ 299 +++ + LL +AG V VA +Q Q Sbjct: 288 AFTFARMLIAQEGLLCGGSAGSTVAVAVKAAQELQ 322 >4COO-A nrPDB Length = 563 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 75/276 (27%), Positives = 112/276 (40%), Gaps = 31/276 (11%) Query: 41 NLFFKCELFQKTGSFKIRGALNAVRSLVPDALERKPKAVVTHSSGNHGQALTYAAKLEGI 100 L KCE F GS K R +L + D + ++ +SGN G L AA + G Sbjct: 126 ELLAKCEFFNAGGSVKDRISLRMIEDAERDGTLKPGDTIIEPTSGNTGIGLALAAAVRGY 185 Query: 101 PAYIVVPQTAPDCKKLAIQAYGASIVYCE-----PSDESRENVAKRVTEE--TEGIMVHP 153 IV+P+ K ++A GA IV S ES VA R+ E I+ Sbjct: 186 RCIIVMPEKMSSEKVDVLRALGAEIVRTPTNARFDSPESHVGVAWRLKNEIPNSHILDQY 245 Query: 154 NQEPAVIAGQGTIALEVLNQVP-LVDALVVPVGGGGMLAGIAITVKALKPSVKVYAAEPS 212 +A T A E+L Q +D LV VG GG + GIA +K P ++ +P Sbjct: 246 RNASNPLAHYDTTADEILQQCDGKLDMLVASVGTGGTITGIARKLKEKCPGCRIIGVDPE 305 Query: 213 NADDCYQSKLKGKLMPNLYPPETIADGVKSS-----IGLNTWPII--RDLVDDIFTVTED 265 + L PE + +++ IG + P + R +VD F ++ Sbjct: 306 GS--------------ILAEPEELNQTEQTTYEVEGIGYDFIPTVLDRTVVDKWFKSNDE 351 Query: 266 EIKCATQLVWERMKLLIEPTAG--VGVAAVLSQHFQ 299 E +++ + LL +AG V VA +Q Q Sbjct: 352 EAFTFARMLIAQEGLLCGGSAGSTVAVAVKAAQELQ 387 >5MMS-A nrPDB Length = 408 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 75/275 (27%), Positives = 112/275 (40%), Gaps = 31/275 (11%) Query: 42 LFFKCELFQKTGSFKIRGALNAVRSLVPDALERKPKAVVTHSSGNHGQALTYAAKLEGIP 101 L KCE F GS K R +L + D + ++ +SGN G L AA + G Sbjct: 105 LLAKCEFFNAGGSVKDRISLRMIEDAERDGTLKPGDTIIEPTSGNTGIGLALAAAVRGYR 164 Query: 102 AYIVVPQTAPDCKKLAIQAYGASIVYCE-----PSDESRENVAKRVTEE--TEGIMVHPN 154 IV+P+ K ++A GA IV S ES VA R+ E I+ Sbjct: 165 CIIVMPEKMSSEKVDVLRALGAEIVRTPTNARFDSPESHVGVAWRLKNEIPNSHILDQYR 224 Query: 155 QEPAVIAGQGTIALEVLNQVP-LVDALVVPVGGGGMLAGIAITVKALKPSVKVYAAEPSN 213 +A T A E+L Q +D LV VG GG + GIA +K P ++ +P Sbjct: 225 NASNPLAHYDTTADEILQQCDGKLDMLVASVGTGGTITGIARKLKEKCPGCRIIGVDPEG 284 Query: 214 ADDCYQSKLKGKLMPNLYPPETIADGVKSS-----IGLNTWPII--RDLVDDIFTVTEDE 266 + L PE + +++ IG + P + R +VD F ++E Sbjct: 285 S--------------ILAEPEELNQTEQTTYEVEGIGYDFIPTVLDRTVVDKWFKSNDEE 330 Query: 267 IKCATQLVWERMKLLIEPTAG--VGVAAVLSQHFQ 299 +++ + LL +AG V VA +Q Q Sbjct: 331 AFTFARMLIAQEGLLCGGSAGSTVAVAVKAAQELQ 365 >6NMX-A nrPDB Length = 354 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 87/331 (26%), Positives = 143/331 (43%), Gaps = 35/331 (10%) Query: 26 TPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVRSLVPDALERKPKAVVTHSSG 85 TP++ L++ G L K E TGSFK RG + AV A E ++ S+G Sbjct: 31 TPLIHLPKLSEQLGIELHVKTEGVNPTGSFKDRGMVMAVAK----AKEEGNDTIMCASTG 86 Query: 86 NHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQA--YGASIVYCEPSDESRENVAKRVT 143 N A A + +++P KLA QA YGA I+ + + + + + + Sbjct: 87 NTSAAAAAYAARANMKCIVIIPNGKIAFGKLA-QAVMYGAEIIAIDGNFDDALKIVRSIC 145 Query: 144 EETEGIMVHPNQEPAVIAGQGTIALEVLNQVPLV-DALVVPVGGGGMLAGIAITVKALK- 201 E++ +V+ + P + GQ T A EV Q+ D L +PVG G ++ K Sbjct: 146 EKSPIALVN-SVNPYRLEGQKTAAFEVCEQLGEAPDVLAIPVGNAGNISAYWKGFKEYHE 204 Query: 202 ------PSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGVKSSIGL-NTWPIIRD 254 P ++ + AE S A ++ +++ N PETIA ++ IG +W Sbjct: 205 KNGTSLPKMRGFEAEGSAA------IVRNEVIEN---PETIATAIR--IGNPASWDKAVK 253 Query: 255 LVDD----IFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQTVSPEVKNICI 310 ++ I VT+DEI A QL+ + EP + +A VL Q P+ + Sbjct: 254 AAEESNGKIDEVTDDEILHAYQLIAREEGVFAEPGSCASIAGVLKQVKSGEIPKGSKVVA 313 Query: 311 VLSGGNV---DLTSSITWVKQAERPASYQSV 338 VL+G + + I+ +K P + S+ Sbjct: 314 VLTGNGLKDPNTAVDISEIKPVTLPTNEDSI 344 >2D1F-A nrPDB Length = 360 Score = 60.8 bits (146), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 56/168 (33%), Positives = 82/168 (48%), Gaps = 12/168 (7%) Query: 26 TPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVRSLVPDALERKPKAVVTHSSG 85 TP++ ++ L++ TG + K E TGSFK RG AV DAL +AV+ S+G Sbjct: 39 TPLIAATNLSKQTGCTIHLKVEGLNPTGSFKDRGMTMAVT----DALAHGQRAVLCASTG 94 Query: 86 NHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQA--YGASIVYCEPSDESRENVAKRVT 143 N + A GI +++PQ KLA QA +GA I+ + + + +A+++ Sbjct: 95 NTSASAAAYAARAGITCAVLIPQGKIAMGKLA-QAVMHGAKIIQIDGNFDDCLELARKMA 153 Query: 144 EETEGIMVHPNQEPAVIAGQGTIALE---VLNQVPLVDALVVPVGGGG 188 + I + + P I GQ T A E VL P V AL PVG G Sbjct: 154 ADFPTISLVNSVNPVRIEGQKTAAFEIVDVLGTAPDVHAL--PVGNAG 199 >4H27-A nrPDB Length = 364 Score = 58.9 bits (141), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 89/314 (28%), Positives = 144/314 (45%), Gaps = 34/314 (10%) Query: 26 TPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVRSLVPDALERKPKAVVTHSSG 85 TP+ S L+++ G +++ K + Q +GSFKIRG + + V SSG Sbjct: 47 TPIRDSMALSKMAGTSVYLKMDSAQPSGSFKIRGIGHFCKRWAKQGCAH----FVCSSSG 102 Query: 86 NHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASI-VYCEPSDESRENVAKRVTE 144 N G A YAA+ G+PA IVVP T P ++ GA++ V E DE+ E +AK + + Sbjct: 103 NAGMAAAYAARQLGVPATIVVPGTTPALTIERLKNEGATVKVVGELLDEAFE-LAKALAK 161 Query: 145 ETEG-IMVHPNQEPAVIAGQGTIALEV---LNQVPLVDALVVPVGGGGMLAGIAITVKAL 200 G + + P +P + G +I E+ L + P AL V + V+ L Sbjct: 162 NNPGWVYIPPFDDPLIWEGHASIVKELKETLWEKPGAIALSVG-----GGGLLCGVVQGL 216 Query: 201 KP----SVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIAD--GVKSSIGLNTWPIIRD 254 + V V A E A + + GKL+ +L ++A GVK ++G + ++ Sbjct: 217 QEVGWGDVPVIAMETFGAHSFHAATTAGKLV-SLPKITSVAKALGVK-TVGAQALKLFQE 274 Query: 255 LVDDIFT--VTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQTV-------SPEV 305 IF+ +++ E A + + K+L+EP G +AAV S Q + +P Sbjct: 275 --HPIFSEVISDQEAVAAIEKFVDDEKILVEPACGAALAAVYSHVIQKLQLEGNLRTPLP 332 Query: 306 KNICIVLSGGNVDL 319 + IV G N+ L Sbjct: 333 SLVVIVCGGSNISL 346 >3PC3-A nrPDB Length = 527 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 57/207 (27%), Positives = 93/207 (44%), Gaps = 16/207 (7%) Query: 18 NIRDSIHLTPVLTSSILNQLTGRN-----LFFKCELFQKTGSFKIRGALNAVRSLVPDAL 72 NI + I TP++ LN + + ++ KCE GS K R V+ L Sbjct: 53 NILEVIGCTPLVK---LNNIPASDGIECEMYAKCEFLNPGGSVKDRIGYRMVQDAEEQGL 109 Query: 73 ERKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVY--CEP 130 + ++ +SGN G L A ++G IV+P+ + K A++ GA I+ E Sbjct: 110 LKPGYTIIEPTSGNTGIGLAMACAVKGYKCIIVMPEKMSNEKVSALRTLGAKIIRTPTEA 169 Query: 131 SDESREN---VAKRVTEETEGIMVHPNQEPA--VIAGQGTIALEVLNQVP-LVDALVVPV 184 + +S E VA+++ ET +V A +A A E+L Q+ VD +VV Sbjct: 170 AYDSPEGLIYVAQQLQRETPNSIVLDQYRNAGNPLAHYDGTAAEILWQLDNKVDMIVVSA 229 Query: 185 GGGGMLAGIAITVKALKPSVKVYAAEP 211 G G ++GI +K PS ++ +P Sbjct: 230 GTAGTISGIGRKIKEQVPSCQIVGVDP 256 >3FCA-A nrPDB Length = 291 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 69/277 (24%), Positives = 124/277 (44%), Gaps = 30/277 (10%) Query: 44 FKCELFQKTGSFKIRGALNAVRSLVPDALERK--PKAVVTHSSGNHGQALTYAAKLEGIP 101 K E GS K R AL ++ DA +R +V +SGN G A+ G Sbjct: 23 LKLEKNNPGGSVKDRPAL----FMILDAEKRGLLKNGIVEPTSGNMGIAIAMIGAKRGHR 78 Query: 102 AYIVVPQTAPDCKKLAIQAYGASIVYCEPSDESRENVAKR---VTEETEGIMVHPNQEP- 157 + +P+T ++ ++ GA +V P + + ++ ++ ET M++ + P Sbjct: 79 VILTMPETMSVERRKVLKMLGAELVLT-PGELGMKGAVEKALEISRETGAHMLNQFENPY 137 Query: 158 AVIAGQGTIALEVLNQVPL-VDALVVPVGGGGMLAGIAITVKAL-KPSVKVYAAEPSNAD 215 V + Q T E+L Q+ +DA V VG GG ++G+ +K VK+ A EP+ Sbjct: 138 NVYSHQFTTGPEILKQMDYQIDAFVAGVGTGGTISGVGRVLKGFFGNGVKIVAVEPA--- 194 Query: 216 DCYQSKLKGKLMPNLYPPETIADGVKSSIGLNTWPII--RDLVDDIFTVTEDEIKCATQL 273 K ++ P + G IG P I R ++D++ TV ++E + Sbjct: 195 -------KSPVLSGGQPGKHAIQG----IGAGFVPKILDRSVIDEVITVEDEEAYEMARY 243 Query: 274 VWERMKLLIEPTAGVGVAAVLSQHFQTVSPEVKNICI 310 + ++ LL+ ++G VAA L + Q + P+ + + + Sbjct: 244 LAKKEGLLVGISSGANVAAAL-KVAQKLGPDARVVTV 279 >5I7O-A nrPDB Length = 326 Score = 53.9 bits (128), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 58/213 (27%), Positives = 95/213 (44%), Gaps = 13/213 (6%) Query: 41 NLFFKCELFQKTGSFKIRGALNAVRSLVPDALERKPKAVVTHSSGNHGQALTYAAKLEGI 100 L+ K E TGS K R A+ + D L R ++ +SGN G +L AA+L+G Sbjct: 39 RLWAKLEDRNPTGSIKDRPAVRMIEQAEADGLLRPGATILEPTSGNTGISLAMAARLKGY 98 Query: 101 PAYIVVPQTAPDCKKLAIQAYGASIVYCEPSDESRENVAKRVTEETEG-----IMVHPNQ 155 V+P+ ++ ++ YGA I++ + E N A +E +M++ Sbjct: 99 RLICVMPENTSVERRQLLELYGAQIIFS--AAEGGSNTAVATAKELAATNPSWVMLYQYG 156 Query: 156 EPAVIAGQ--GTIALEVLNQVPLVDALVVPVGGGGMLAGIAITVKALKPSVKVYAAEPSN 213 PA GT E+L +P + V +G G L G ++ +VK+ AAEP Sbjct: 157 NPANTDSHYCGT-GPELLADLPEITHFVAGLGTTGTLMGTGRFLREHVANVKIVAAEPRY 215 Query: 214 ADDCYQSK-LKGKLMPNLYPPETIADGVKSSIG 245 + Y + + +P LY PE + + S+G Sbjct: 216 GEGVYALRNMDEGFVPELYDPEILT--ARYSVG 246 >5D84-A nrPDB Length = 326 Score = 53.5 bits (127), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 55/208 (26%), Positives = 98/208 (47%), Gaps = 19/208 (9%) Query: 16 HINIRDSIHLTPVLTSSILNQLTGRN-LFFKCELFQKTGSFKIRGALNAVRSLVPDALER 74 H ++ DS+ TP++ L+QL ++ +F K E GS K R A + + L Sbjct: 9 HDSLLDSVGQTPMVQ---LHQLFPKHEVFAKLEYMNPGGSMKDRPAKYIIEHGIKHGLIT 65 Query: 75 KPKAVVTHSSGNHGQALTYAAKLEGIPAYIVV-PQTAPDCKKLAIQAYGASIVYCEPSDE 133 + ++ +SGN G AL AK++G+ VV P+ +P K+ I++YGA++ E D Sbjct: 66 ENTHLIESTSGNLGIALAMIAKIKGLKLTCVVDPKISPTNLKI-IKSYGANVEMVEEPDA 124 Query: 134 SRENVAKRVTEETE---------GIMVHPNQ--EPAVIAGQGTIALEVLNQVPLVDALVV 182 + R+ + E I + N+ + G GT +E + Q +D V Sbjct: 125 HGGYLMTRIAKVQELLATIDDAYWINQYANELNWQSHYHGAGTEIVETIKQP--IDYFVA 182 Query: 183 PVGGGGMLAGIAITVKALKPSVKVYAAE 210 PV G + G++ +K + P+ ++ A + Sbjct: 183 PVSTTGSIMGMSRKIKEVHPNAQIVAVD 210 >2RKB-A nrPDB Length = 318 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 87/319 (27%), Positives = 147/319 (46%), Gaps = 50/319 (15%) Query: 25 LTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVRSLVPDALERKPKAVVTHSS 84 +TP+L S L+Q+ G +F KCE Q +GSFKIRG + + ++ + +V S Sbjct: 7 VTPLLESWALSQVAGMPVFLKCENVQPSGSFKIRG----IGHFCQEMAKKGCRHLVCSSG 62 Query: 85 GNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASI-----VYCEPSDESRENVA 139 GN G A YAA+ GIPA IV+P++ +Q GA + V+ E + ++E +A Sbjct: 63 GNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTGKVWDEANLRAQE-LA 121 Query: 140 KRVTEETEGIMVHPNQEPAVIAGQGTIA--LEVLNQVPLVDALVVPVGGGGMLAGIAITV 197 KR E V P P + G ++ L+ + + P ++ GGG + +A + Sbjct: 122 KRDGWEN----VPPFDHPLIWKGHASLVQELKAVLRTPPGALVLAVGGGGLLAGVVAGLL 177 Query: 198 KALKPSVKVYAAEPSNADDCYQSKLK-GKLMPNLYPPETIAD--GVKSSIGLNT------ 248 + V + A E A C+ + + GKL+ T+ D V S+G T Sbjct: 178 EVGWQHVPIIAMETHGA-HCFNAAITAGKLV-------TLPDITSVAKSLGAKTVAARAL 229 Query: 249 -----WPIIRDLVDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLS------QH 297 I ++V+D V+ A Q + + ++L+EP G +AA+ S Q Sbjct: 230 ECMQVCKIHSEVVEDTEAVS------AVQQLLDDERMLVEPACGAALAAIYSGLLRRLQA 283 Query: 298 FQTVSPEVKNICIVLSGGN 316 + P + ++ +++ GGN Sbjct: 284 EGCLPPSLTSVVVIVCGGN 302 >5C3U-A nrPDB Length = 366 Score = 51.6 bits (122), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 86/342 (25%), Positives = 158/342 (46%), Gaps = 37/342 (10%) Query: 9 FADVEKAHINIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVRSLV 68 F D++ H+ TP+L + L + N+F K E Q +GS K+RG + + Sbjct: 12 FDDLQSLHV-------ATPLLHAPNLTKELECNVFLKMENIQPSGSVKMRG----IGAFC 60 Query: 69 PDALERKPKAV--VTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIV 126 A++ + + V S N A++Y A+ G+ A IVVP+ + +I+ G+ ++ Sbjct: 61 YQAVQTRGTNIQFVCGSGPNTVLAVSYCARQLGVEAIIVVPKATNERICQSIRTDGSHLI 120 Query: 127 YCEPSDESRENVAKRVTEETEGIMVHPNQEPAVIAGQGTIALEV---LNQVPLVDALVVP 183 + + E A+++ GI V + + G TI E+ LN P A++ P Sbjct: 121 LYGENWTAAEVHARKLVRRN-GIYVPSSDHALIWQGHSTIVQELKTQLNDNPPA-AIICP 178 Query: 184 VGGGGMLAGIAITVK-ALKPSVKVYAAEPSNADDCYQSKLKGKLM----PNLYPPETIAD 238 VGGGG+L G+ + ++ A V V A E ++ S + G+L+ N I+ Sbjct: 179 VGGGGLLNGVIMGLQEADWKDVPVIAVETHGSNAFQASVVAGELVIMEKNNTIATSLISK 238 Query: 239 GVKS---SIGLNTWPIIRDLVDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLS 295 V S + LN P++ F V++ A +L E K+L+E +AG ++ + Sbjct: 239 AVSSKSLELSLNH-PVVP------FAVSDAMAADAVRLFAEDFKMLVEASAGAALSLCYT 291 Query: 296 QHFQTVSPEV---KNICIVLSGG-NVDLTSSITWVKQAERPA 333 + + P + K++ ++++GG ++ L + K+ PA Sbjct: 292 HLIRDILPSLSPAKDVVVLVTGGSDISLAHLDEYRKKYMHPA 333 >5B1I-A nrPDB Length = 311 Score = 51.2 bits (121), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 52/186 (27%), Positives = 84/186 (45%), Gaps = 19/186 (10%) Query: 41 NLFFKCELFQKTGSFKIRGALNAVRSLVPDALER----KPKAVVTHSSGNHGQALTYAAK 96 +++ K E+F GS R L A L+ D L+R ++ ++GN G L A + Sbjct: 27 HIYAKLEMFNPGGSIADR--LGAY--LIEDGLQRGRVNAKTTIIEPTAGNTGIGLALATQ 82 Query: 97 LEGIPAYIVVPQTAPDCKKLAIQAYGASIVYCEPSDES-------RENVAKRVTEETEGI 149 + +VVP+ K++ +QA GA IV+ PS+E E +A ++ + Sbjct: 83 AHHLRTILVVPEKFSMEKQVLMQALGAEIVHT-PSEEGIKGAIRKAEALAATISNSYVPM 141 Query: 150 MVHPNQEPAVIAGQGTIALEVLNQVPL-VDALVVPVGGGGMLAGIAITVKALKPSVKVYA 208 PA A T+A E+L +P + A V G GG AG+A ++A + K Sbjct: 142 QFKNPANPA--AYYHTLAPEILADMPAPITAFVAGAGSGGTFAGVAAYLQAQDSATKAVV 199 Query: 209 AEPSNA 214 EP + Sbjct: 200 VEPEGS 205 >6C2H-A nrPDB Length = 375 Score = 50.8 bits (120), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 75/301 (24%), Positives = 128/301 (42%), Gaps = 39/301 (12%) Query: 18 NIRDSIHLTPVLTSSILNQLTG--RNLFFKCELFQKTGSFKIRGALNAVRSLVPDA---- 71 N+ D + TP++ L + G ++ K EL+ GS K R A +S+V +A Sbjct: 35 NVIDLVGNTPLIALKKLPKALGIKPQIYAKLELYNPGGSIKDRIA----KSMVEEAEASG 90 Query: 72 -LERKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYCE- 129 + ++ +SGN G L ++G I +P+ + K ++A GA I+ Sbjct: 91 RIHPSRSTLIEPTSGNTGIGLALIGAIKGYRTIITLPEKMSNEKVSVLKALGAEIIRTPT 150 Query: 130 ----PSDESRENVAKRVTEETEGI--------MVHPNQEPAVIAGQGTIALEVLNQVPLV 177 S ES VAK++ +E G M++P + LE LN + Sbjct: 151 AAAWDSPESHIGVAKKLEKEIPGAVILDQYNNMMNPEAHYFGTGREIQRQLEDLNLFDNL 210 Query: 178 DALVVPVGGGGMLAGIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIA 237 A+V G GG ++GI+ +K +++ A+P + S L P I Sbjct: 211 RAVVAGAGTGGTISGISKYLKEQNDKIQIVGADP------FGSILA---QPENLNKTDIT 261 Query: 238 DGVKSSIGLNTWPII--RDLVDDIFTVTEDE--IKCATQLVWERMKLLIEPTAGVGVAAV 293 D IG + P + R L+ D++ T+D+ K A QL+ +L+ ++G AV Sbjct: 262 DYKVEGIGYDFVPQVLDRKLI-DVWYKTDDKPSFKYARQLI-SNEGVLVGGSSGSAFTAV 319 Query: 294 L 294 + Sbjct: 320 V 320 >5OHX-A nrPDB Length = 504 Score = 50.8 bits (120), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 72/285 (25%), Positives = 124/285 (43%), Gaps = 24/285 (8%) Query: 42 LFFKCELFQKTGSFKIRGALNAVRSLVPDALERKPKAVVTHSSGNHGQALTYAAKLEGIP 101 ++ KCE GS K R A ++ L + ++ +SGN G L AA + G Sbjct: 64 IYAKCEFLNPGGSVKDRIAYRMIQDAEDKGLLKPGCTIIEPTSGNTGIGLAMAAAVRGYK 123 Query: 102 AYIVVPQTAPDCKKLAIQAYGASIVYCEP-----SDESRENVAKRVTEET-EGIMVHPNQ 155 IV+P+ D K + A GA I+ S E+ +VA+++ +E I++ Sbjct: 124 CIIVMPEKMSDEKISTLYALGAKIIRTPTEASWHSPEAHISVAQKLQKEIPNSIILDQYT 183 Query: 156 EPAV-IAGQGTIALEVLNQVP-LVDALVVPVGGGGMLAGIAITVKALKPSVKVYAAEPSN 213 P +A A+E+ Q +D LV G GG ++GI +K L P++K+ A +P Sbjct: 184 NPGNPLAHYDQTAIEIWKQCEGKIDYLVAGAGTGGTISGIGRKLKELSPNIKIIAVDP-- 241 Query: 214 ADDCYQSKLKGKLM-PNLYPPETIADGVKSSIGLNTWPII--RDLVDDIFTVTEDEIKCA 270 KG ++ P+ + IG + P + R+++D ++E A Sbjct: 242 ---------KGSILDPSSDSQNEVGFYEVEGIGYDFIPTVLDRNVIDKWIKTEDNESLNA 292 Query: 271 TQLVWERMKLLIEPTAGVGVAAVLSQHFQTVSPEVKNICIVLSGG 315 +++ + LL ++G + A L PE K + I+L G Sbjct: 293 ARMLIRQEGLLCGGSSGAALIAALKIAKDI--PEEKRMVIILPDG 335 >2ZSJ-A nrPDB Length = 352 Score = 49.3 bits (116), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 51/170 (30%), Positives = 84/170 (49%), Gaps = 15/170 (8%) Query: 26 TPVLTSSILNQLTG--RNLFFKCELFQKTGSFKIRGALNAVRSLVPDALERKPKAVVTHS 83 TP++ + L + G ++ K E TGSFK RG A+ A+E +AV+ S Sbjct: 31 TPLIEADNLARAIGFKGKIYLKYEGLNPTGSFKDRGMTLAISK----AVEAGKRAVICAS 86 Query: 84 SGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQA--YGASIVYCEPSDESRENVAKR 141 +GN + A G+ AY+++P+ A KL+ QA YGA ++ + + + N+ ++ Sbjct: 87 TGNTSASAAAYAARAGLRAYVLLPKGAVAIGKLS-QAMIYGAKVLAIQGTFDDALNIVRK 145 Query: 142 VTEETEGIMVHPNQEPAVIAGQGTIALEV---LNQVPLVDALVVPVGGGG 188 + E +V+ + P I GQ T A E+ L + P D +PVG G Sbjct: 146 IGENFPVEIVN-SVNPYRIEGQKTAAFEICDTLGEAP--DYHFIPVGNAG 192 >2PQM-A nrPDB Length = 343 Score = 48.1 bits (113), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 72/275 (26%), Positives = 115/275 (41%), Gaps = 28/275 (10%) Query: 13 EKAHINIRDSIHLTPVLTSSILNQ----LTGRNLFFKCELFQKTGSFKIRGALNAVRSLV 68 ++ + NI ++I TP++ + + G + K E F S K R N V + Sbjct: 11 KRIYHNILETIGGTPLVELHGVTEHPRIKKGTRILVKLEYFNPMSSVKDRVGFNIVYQAI 70 Query: 69 PDALERKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYC 128 D + ++ +SGN G AL A + G I +P T +++ ++A+GA ++ Sbjct: 71 KDGRLKPGMEIIESTSGNTGIALCQAGAVFGYRVNIAMPSTMSVERQMIMKAFGAELILT 130 Query: 129 EPSD---ESRENVAKRVTEETEGIMVHPNQ--EPAVIAGQGTIALEVLNQVP-LVDALVV 182 E + E V K + +E G NQ P A A E+ VD +V Sbjct: 131 EGKKGMPGAIEEVNKMI-KENPGKYFVANQFGNPDNTAAHHYTANEIWEDTDGEVDIVVS 189 Query: 183 PVGGGGMLAGIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGVKS 242 VG G + G+A +K K +K+ A EP + + K KG P I Sbjct: 190 AVGTSGTVIGVAEKLKEKKKGIKIIAVEPEES-AVLEGKAKG--------PHGI-----Q 235 Query: 243 SIGLNTWPII--RDLVDDIFTV-TEDEIKCATQLV 274 IG P I ++ VD+I + T+D K A +V Sbjct: 236 GIGAGFIPDIYKKEFVDEIIPIKTQDAWKMARAVV 270 >2JC3-A nrPDB Length = 303 Score = 47.8 bits (112), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 50/201 (24%), Positives = 90/201 (44%), Gaps = 12/201 (5%) Query: 19 IRDSIHLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVRSLVPDALER---K 75 + +I TP++ + G ++ K E GS K R AL S++ +A +R K Sbjct: 4 LEQTIGNTPLVKLQRIGPDNGSEIWVKLEGNNPAGSVKDRAAL----SMIVEAEKRGEIK 59 Query: 76 PKAVVTH-SSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYC--EPSD 132 P V+ +SGN G AL A L+G +++P ++ A++AYGA ++ E Sbjct: 60 PGDVLIEATSGNTGIALAMIAALKGYRMKLLMPDNMSQERRAAMRAYGAELILVTKEQGM 119 Query: 133 ESRENVAKRVTEETEGIMVHPNQEPAV-IAGQGTIALEVLNQVP-LVDALVVPVGGGGML 190 E ++A ++E EG ++ P A T E+ Q + V +G G + Sbjct: 120 EGARDLALAMSERGEGKLLDQFNNPDNPYAHYTTTGPEIWRQTSGRITHFVSSMGTTGTI 179 Query: 191 AGIAITVKALKPSVKVYAAEP 211 G++ ++ + V + +P Sbjct: 180 TGVSRFLREQEKPVTIVGLQP 200 >4OFX-A nrPDB Length = 319 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 37/134 (27%), Positives = 61/134 (45%), Gaps = 7/134 (5%) Query: 18 NIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVRSLVPDALERKPK 77 NI I TPV+ + Q L+ KCE GS K R + S + Sbjct: 8 NILQVIGKTPVVRLHRIGQSLPCELYGKCEFLNPGGSVKDRIGAAMIESAEKQGKIKPGD 67 Query: 78 AVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYCEPSD----- 132 ++ +SGN G + A ++G I +P+ K++ ++A GA+I Y P++ Sbjct: 68 TLIEPTSGNTGIGIALAGAVKGYRVIITMPEKMSHEKQVVLEALGATI-YRTPTEAAYDD 126 Query: 133 -ESRENVAKRVTEE 145 ES ++AKR+ +E Sbjct: 127 PESHISLAKRLNQE 140 >5YGR-A nrPDB Length = 404 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 46/204 (22%), Positives = 91/204 (44%), Gaps = 18/204 (8%) Query: 69 PDALER-KPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVY 127 P+ E+ K VT + GNHG+ + +AA+ G+ A + +P+ + + I+ +GA Sbjct: 109 PEIKEKIKDCVFVTATDGNHGRGVAWAAEQLGLKAVVYMPKGSSLIRAENIRHHGAECTI 168 Query: 128 CEPSDESRENVAKRVTEETEGIMVHPNQEPA-------VIAGQGTIALEVLNQV-----P 175 + + + +A R+ + +++ ++ G T+A+E Q+ P Sbjct: 169 TDLNYDDAVRLAHRMAQTKGWVLLQDTAWTGYEEIPTWIMQGYMTLAVEAYEQLAETNSP 228 Query: 176 LVDALVVPVGGGGMLAGI-AITVKALKPSV-KVYAAEPSNADDCYQSKLKGKLMPNLYPP 233 L L++ G G + V+ ++ ++ + EP A+ YQS + P+ Sbjct: 229 LPTHLILQAGVGSFAGSVMGYFVEKMQENIPNIIVVEPHQANCLYQSAVMDDGQPHCVTG 288 Query: 234 E--TIADGVK-SSIGLNTWPIIRD 254 + TI G+ + +WPIIRD Sbjct: 289 DMATIMAGLACGEPNIISWPIIRD 312 >2EFY-A nrPDB Length = 304 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 82/322 (25%), Positives = 133/322 (41%), Gaps = 37/322 (11%) Query: 17 INIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVRSLVPDALER-- 74 + + +I TPV+ + + + ++ K E GS K R A ++ DA ER Sbjct: 1 MRVEGAIGKTPVVRLAKVVEPDMAEVWVKLEGLNPGGSIKDRPAWYMIK----DAEERGI 56 Query: 75 -KP---KAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYCEP 130 +P + +V +SGN G L A G + +P + +K ++A+GA +V +P Sbjct: 57 LRPGSGQVIVEPTSGNTGIGLAMIAASRGYRLILTMPAQMSEERKRVLKAFGAELVLTDP 116 Query: 131 SDE---SRENVAKRVTEETEGIMVHPNQEPA-VIAGQGTIALEVLNQVP-LVDALVVPVG 185 +RE A R+ EE M + PA V A T E+ + +DA V G Sbjct: 117 ERRMLAAREE-ALRLKEELGAFMPDQFKNPANVRAHYETTGPELYEALEGRIDAFVYGSG 175 Query: 186 GGGMLAGIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYP---PETIADGVKS 242 GG + G+ +K P VKV A EP+ ++ K+ + P PE + Sbjct: 176 TGGTITGVGRYLKERIPHVKVIAVEPARSNVLSGGKMGQHGFQGMGPGFIPENLD----- 230 Query: 243 SIGLNTWPIIRDLVDDIFTV-TEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQTV 301 L+D + V ED A +L E L + G+ AA+ Q + + Sbjct: 231 ----------LSLLDGVIQVWEEDAFPLARRLAREEGLFLGMSSGGIVWAAL--QVAREL 278 Query: 302 SPEVKNICIVLSGGNVDLTSSI 323 P + CI GG L++ + Sbjct: 279 GPGKRVACISPDGGWKYLSTPL 300 >2BHS-A nrPDB Length = 303 Score = 45.8 bits (107), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 39/145 (26%), Positives = 67/145 (46%), Gaps = 10/145 (6%) Query: 19 IRDSIHLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVRSLVPDALER---K 75 + +I TP++ + G ++ K E GS K R AL S++ +A +R K Sbjct: 4 LEQTIGNTPLVKLQRMGPDNGSEVWLKLEGNNPAGSVKDRAAL----SMIVEAEKRGEIK 59 Query: 76 PKAVVTH-SSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYC--EPSD 132 P V+ +SGN G AL A L+G +++P ++ A++AYGA ++ E Sbjct: 60 PGDVLIEATSGNTGIALAMIAALKGYRMKLLMPDNMSQERRAAMRAYGAELILVTKEQGM 119 Query: 133 ESRENVAKRVTEETEGIMVHPNQEP 157 E ++A + EG ++ P Sbjct: 120 EGARDLALEMANRGEGKLLDQFNNP 144 >1UIN-A nrPDB Length = 351 Score = 45.8 bits (107), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 50/154 (32%), Positives = 74/154 (48%), Gaps = 11/154 (7%) Query: 39 GRNLFFKCELFQKTGSFKIRGALNAVRSLVPDALERKPKAVVTHSSGNHGQALTYAAKLE 98 G L+ K E TGSFK RG AV A+E +AV S+GN + A Sbjct: 44 GIRLYAKYEGLNPTGSFKDRGMTLAVS----KAVEGGAQAVACASTGNTAASAAAYAARA 99 Query: 99 GIPAYIVVPQTAPDCKKLAIQ-AYGASIVYCEPSDESRENVAKRVTEETEGIMVHPNQEP 157 GI A +V+P K+A +GA IV E + + + +++TE +V+ + P Sbjct: 100 GILAIVVLPAGYVALGKVAQSLVHGARIVQVEGNFDDALRLTQKLTEAFPVALVN-SVNP 158 Query: 158 AVIAGQGTIALEVLNQV---PLVDALVVPVGGGG 188 + GQ T+A EV++++ P AL PVG G Sbjct: 159 HRLEGQKTLAFEVVDELGDAPHYHAL--PVGNAG 190 >2Q3D-A nrPDB Length = 313 Score = 45.4 bits (106), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 73/264 (27%), Positives = 115/264 (43%), Gaps = 27/264 (10%) Query: 41 NLFFKCELFQKTGSFKIRGALNAVRSLVPDALERKPKAVVTHSSGNHGQALTYAAKLEGI 100 ++ K E F S K R + +++ L + ++ +SGN G AL G Sbjct: 32 DIVAKLEFFNPANSVKDRIGVAMLQAAEQAGLIKPDTIILEPTSGNTGIALAMVCAARGY 91 Query: 101 PAYIVVPQTAPDCKKLAIQAYGASIVYCEPSDESRENVAKRVTEE---TEGIMVHPNQ-- 155 + +P+T +++ ++AYGA ++ +D +AK EE T+ P Q Sbjct: 92 RCVLTMPETMSLERRMLLRAYGAELILTPGADGMSGAIAK--AEELAKTDQRYFVPQQFE 149 Query: 156 ---EPAVIAGQGTIALEVLNQVP-LVDALVVPVGGGGMLAGIAITVKALKPSVKVYAAEP 211 PA+ + T A EV VD +V VG GG + G+A +K KPS + A EP Sbjct: 150 NPANPAI--HRVTTAEEVWRDTDGKVDIVVAGVGTGGTITGVAQVIKERKPSARFVAVEP 207 Query: 212 SNADDCYQSKLKGKLMPNLYPPETIADGVKSSIGLNTWPIIRDLVDDIFTV-TEDEIKCA 270 + A KG +P + I G + + +DLVD+I TV ED + A Sbjct: 208 A-ASPVLSGGQKGP-----HPIQGIGAGFVPPV------LDQDLVDEIITVGNEDALNVA 255 Query: 271 TQLVWERMKLLIEPTAGVGVAAVL 294 +L E LL+ ++G A L Sbjct: 256 RRLAREE-GLLVGISSGAATVAAL 278 >5B55-A nrPDB Length = 340 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 29/101 (28%), Positives = 47/101 (46%) Query: 26 TPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVRSLVPDALERKPKAVVTHSSG 85 TP+L + R +F K E + TGS K R A ++ +K +V +SG Sbjct: 20 TPMLELIFDYKGEERRIFVKNESYNLTGSIKDRMAFYTLKKAYEKNEIKKGAPIVEATSG 79 Query: 86 NHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIV 126 N G A + + G P I +P + +K I+++GA I+ Sbjct: 80 NTGIAFSAMGAILGHPVIIYMPDWMSEERKSLIRSFGAKII 120 >5XW3-A nrPDB Length = 315 Score = 42.7 bits (99), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 50/209 (23%), Positives = 88/209 (42%), Gaps = 21/209 (10%) Query: 19 IRDSIHLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVRSLVPDALER---- 74 + + I TP++ + + G LF K E + GS K R R L+ DALE+ Sbjct: 7 VHELIGHTPIVEITRFSLPEGVRLFAKLEFYNPGGSVKDRLG----RELIEDALEKGLVT 62 Query: 75 KPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYCEPSDES 134 + ++ ++GN G L AA + + VP+ K+ ++A GA++V+ P+++ Sbjct: 63 EGGTIIEPTAGNTGIGLALAALQHDLRVIVCVPEKFSIEKQELMKALGATVVHT-PTEQG 121 Query: 135 RENVAKRVTEETEGIMVHPNQ-EPAVIAGQG-------TIALEVLNQV-PLVDALVVPVG 185 + E I PN P+ A + T+ E+ + + ++ V G Sbjct: 122 MTGAIAKAKELVNEI---PNSYSPSQFANEANPRAYFKTLGPELWSALNGEINIFVAGAG 178 Query: 186 GGGMLAGIAITVKALKPSVKVYAAEPSNA 214 GG G A +K +K EP + Sbjct: 179 TGGTFMGTASYLKEKNIDIKTVIVEPEGS 207 >2EGU-A nrPDB Length = 308 Score = 42.0 bits (97), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 48/180 (26%), Positives = 81/180 (45%), Gaps = 8/180 (4%) Query: 41 NLFFKCELFQKTGSFKIRGALNAVRSLVPDALERKPKAVVTHSSGNHGQALTYAAKLEGI 100 +++ K E S K R AL + + + +V +SGN G L A +G Sbjct: 30 DVYLKLEFMNPGSSVKDRIALAMIEAAEKAGKLKPGDTIVEPTSGNTGIGLAMVAAAKGY 89 Query: 101 PAYIVVPQTAPDCKKLAIQAYGASIVYCEPSDESRENVAKRVTEETEGIMVHPNQ----- 155 A +V+P T ++ ++AYGA +V + R +AK E P Q Sbjct: 90 KAVLVMPDTMSLERRNLLRAYGAELVLTPGAQGMRGAIAKAEELVREHGYFMPQQFKNEA 149 Query: 156 EPAVIAGQGTIALEVLNQV-PLVDALVVPVGGGGMLAGIAITVKALKPSVKVYAAEPSNA 214 P + + T E++ Q+ +DA V VG GG + G ++ P++K+YA EP+++ Sbjct: 150 NPEI--HRLTTGKEIVEQMGDQLDAFVAGVGTGGTITGAGKVLREAYPNIKIYAVEPADS 207 >4I1Y-A nrPDB Length = 314 Score = 41.2 bits (95), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 82/291 (28%), Positives = 121/291 (41%), Gaps = 39/291 (13%) Query: 18 NIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVRSLVPDALER--- 74 NI I TP++ + ++ K E F GS K R + + DA E+ Sbjct: 10 NIAQLIGGTPLVRLRRVTDGAAADVVAKLESFNPAGSIKDRIGVAMI-----DAAEKAGL 64 Query: 75 -KPKAVVTH-SSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYCEPSD 132 KP ++ +SGN G AL + G + +P T +++ ++AYGA +V P Sbjct: 65 IKPDTIILEPTSGNTGIALAMVSAARGYKCVLTMPDTMSIERRMLLRAYGAELVLT-PGA 123 Query: 133 ESRENVAKRVTE--ETEGIMVHPNQ-----EPAVIAGQGTIALEVLNQVP-LVDALVVPV 184 E + E +T+ P Q PAV A T A EV VD V V Sbjct: 124 EGMAGAIAKAEELAKTDDRYFIPQQFENPANPAVHA--VTTAEEVWRDTDGKVDIFVSGV 181 Query: 185 GGGGMLAGIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGVKSSI 244 G GG + G+A +K +PS + A EP+ A KG P I I Sbjct: 182 GTGGTITGVAQVIKQRRPSAQFVAVEPA-ASPVLSGGQKG--------PHPI-----QGI 227 Query: 245 GLNTWPIIRD--LVDDIFTV-TEDEIKCATQLVWERMKLLIEPTAGVGVAA 292 G P + D LVD++ TV +D ++ A ++ E LL ++G V A Sbjct: 228 GAGFVPPVLDLALVDEVITVGNDDALELARRMATEE-GLLFGISSGAAVWA 277 >3VBE-A nrPDB Length = 344 Score = 40.8 bits (94), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 50/203 (24%), Positives = 95/203 (46%), Gaps = 14/203 (6%) Query: 23 IHLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVRSLVPDALERK-----PK 77 I TP++ + + + G + K E+ Q T S K R A +++ DA E+ Sbjct: 33 IGRTPLVYLNKVTEGCGAYVAVKQEMMQPTASIKDRPAY----AMITDAEEKNLITPGKT 88 Query: 78 AVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYCEPSDESREN 137 ++ +SGN G ++ + A ++G + +P +++ ++A+GA ++ +P+ Sbjct: 89 TLIEPTSGNMGISMAFMAAMKGYKMVLTMPSYTSLERRVTMRAFGAELILTDPAKGMGGT 148 Query: 138 VAK--RVTEET-EGIMVHPNQEPAVIAGQ-GTIALEVLNQVP-LVDALVVPVGGGGMLAG 192 V K + E T M+ PA T E+ VD V+ +G GG ++G Sbjct: 149 VKKAYELLENTPNAHMLQQFSNPANTQVHFETTGPEIWEDTNGQVDIFVMGIGSGGTVSG 208 Query: 193 IAITVKALKPSVKVYAAEPSNAD 215 + +K+ P+VK+Y EPS ++ Sbjct: 209 VGQYLKSKNPNVKIYGVEPSESN 231 >3X43-A nrPDB Length = 332 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 75/290 (25%), Positives = 121/290 (41%), Gaps = 32/290 (11%) Query: 18 NIRDSIHLTPVLTSSILNQLTGRN--LFFKCELFQKTGSFKIRGALNAVRSLVPDALERK 75 +I D+I TP++ L ++ + ++ K E F GS K R AL+ V L + Sbjct: 6 SILDTIGRTPIVR---LQRMAPEHTSVYVKVESFNPGGSVKDRLALSVVLDAEAKGLLKP 62 Query: 76 PKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYCEPSDESR 135 +V +SGN G AL A G V+ T ++ I+AYG +V S+ Sbjct: 63 GDTIVECTSGNVGIALAMVAAARGYRFVAVMGDTYSVERRKLIRAYGGKLVLFPGHLGSK 122 Query: 136 EN--VAKRVTEETEGIMVHPNQEPAVIA-GQGTIALEVLNQVP--LVDALVVPVGGGGML 190 +A + E+ PA + + T A E+L +D V G G L Sbjct: 123 GGNLIADELAEKYGWFRARQFDNPANPSYHRETTASEILADFAGKRLDHFVTGFGTTGTL 182 Query: 191 AGIAITVKALKPSVKVYAAEPSNA-----DDCYQSKLKGKLMPNLYPPETIADGVKSSIG 245 G+ ++ +P V+V A EPSNA + +++G L PN P GV Sbjct: 183 TGVGQMLRVARPEVRVVALEPSNAAMLARGEWSPHQIQG-LAPNFVP------GV----- 230 Query: 246 LNTWPIIRDLVDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLS 295 + R ++DD+ T+ E + ++ + + +AG VA LS Sbjct: 231 -----LDRSVIDDLVTMDEVTARDTSRRLAAEEGIFAGISAGATVATALS 275 >6AHI-A nrPDB Length = 314 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 62/290 (21%), Positives = 116/290 (40%), Gaps = 30/290 (10%) Query: 19 IRDSIHLTPVLTSSILNQLTGRN--LFFKCELFQKTGSFKIRGALNAVRSLVPDALERKP 76 ++D+I TPV + + N ++ K E GS K R + Sbjct: 7 MQDAIGRTPVFKFTNKDYPIPLNSAIYAKLEHLNPGGSVKDRLGQYLIGEGFKTGKITSK 66 Query: 77 KAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYCEPSDESRE 136 ++ ++GN G AL A + VVP+ K+ ++A GA +V P+ E Sbjct: 67 TTIIEPTAGNTGIALALVAIKHHLKTIFVVPEKFSTEKQQIMRALGA-LVINTPTSEGIS 125 Query: 137 NVAKRVTEETEGI--------MVHPNQEPAVIAGQGTIALEVLNQVPL-VDALVVPVGGG 187 K+ E E I +P+ A T+A E++ ++ + + V +G G Sbjct: 126 GAIKKSKELAESIPDSYLPLQFENPDNPAAYYH---TLAPEIVQELGTNLTSFVAGIGSG 182 Query: 188 GMLAGIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGVKSSIGLN 247 G AG A +K P++++ EP +G ++ P +G+ Sbjct: 183 GTFAGTARYLKERIPAIRLIGVEP-----------EGSILNGGEPGPHEIEGIGVEF--- 228 Query: 248 TWPIIRDL-VDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQ 296 P +L +D T++++E T+ + ++ LL+ ++G A L + Sbjct: 229 IPPFFENLDIDGFETISDEEGFSYTRKLAKKNGLLVGSSSGAAFVAALKE 278 >5XCN-X nrPDB Length = 350 Score = 39.3 bits (90), Expect = 0.003, Method: Compositional matrix adjust. Identities = 29/100 (29%), Positives = 44/100 (44%) Query: 41 NLFFKCELFQKTGSFKIRGALNAVRSLVPDALERKPKAVVTHSSGNHGQALTYAAKLEGI 100 N+ K E + S K R N V D K K +V +SGN G AL Y A G Sbjct: 61 NVVVKIEGRNPSYSVKCRIGANMVWQAEKDGTLTKGKEIVDATSGNTGIALAYVAAARGY 120 Query: 101 PAYIVVPQTAPDCKKLAIQAYGASIVYCEPSDESRENVAK 140 + +P+T +K + G ++V E + ++ +AK Sbjct: 121 KITLTMPETMSLERKRLLCGLGVNLVLTEGAKGAKGAIAK 160 >2ISQ-A nrPDB Length = 320 Score = 35.8 bits (81), Expect = 0.026, Method: Compositional matrix adjust. Identities = 26/118 (22%), Positives = 53/118 (44%), Gaps = 4/118 (3%) Query: 45 KCELFQKTGSFKIRGALNAVRSLVPDALERKPKAVVTH-SSGNHGQALTYAAKLEGIPAY 103 K E+ + S K R + + L + ++V+ +SGN G L + A +G Sbjct: 33 KLEMMEPCSSVKDRIGFSMISDAEKKGLIKPGESVLIEPTSGNTGVGLAFTAAAKGYKLI 92 Query: 104 IVVPQTAPDCKKLAIQAYGASIVYCEPSDESRENVAKR---VTEETEGIMVHPNQEPA 158 I +P + +++ + A+G +V +P+ + +AK + + G M+ + PA Sbjct: 93 ITMPASMSTERRIILLAFGVELVLTDPAKGMKGAIAKAEEILAKTPNGYMLQQFENPA 150 >5J5V-A nrPDB Length = 323 Score = 35.8 bits (81), Expect = 0.027, Method: Compositional matrix adjust. Identities = 32/112 (28%), Positives = 57/112 (50%), Gaps = 11/112 (9%) Query: 22 SIHLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVRSLVPDALER---KPKA 78 +I TP++ LN++ + K E + SF ++ + A +++ DA +R KP Sbjct: 11 TIGHTPLVR---LNRIGNGRILAKVE--SRNPSFSVKCRIGA--NMIWDAEKRGVLKPGV 63 Query: 79 -VVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYCE 129 +V +SGN G AL Y A G + +P+T ++ ++A GA++V E Sbjct: 64 ELVEPTSGNTGIALAYVAAARGYKLTLTMPETMSIERRKLLKALGANLVLTE 115 >4D9G-A nrPDB Length = 398 Score = 35.4 bits (80), Expect = 0.033, Method: Compositional matrix adjust. Identities = 49/214 (22%), Positives = 88/214 (41%), Gaps = 40/214 (18%) Query: 81 THSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYCEPSDESRENVAK 140 T + GNHG+ + +AA+ G A I +P+ + + AI GA C +D + ++ + Sbjct: 117 TTTDGNHGRGVAWAAQQLGQNAVIYMPKGSAQERVDAILNLGAE---CIVTDMNYDDTVR 173 Query: 141 RVTEETEGIMVHPNQEPA----------VIAGQGTIALEVLNQVPLVDA----LVVPVGG 186 + + Q+ A ++ G T+A E + Q+ + +++ G Sbjct: 174 LTMQHAQQHGWEVVQDTAWEGYTKIPTWIMQGYATLADEAVEQMREMGVTPTHVLLQAGV 233 Query: 187 GGMLAGI-AITVKALKP-SVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGVK--- 241 G M G+ V P ++ EP AD Y+S +KG ++ TI G+ Sbjct: 234 GAMAGGVLGYLVDVYSPQNLHSIIVEPDKADCIYRSGVKGDIVNVGGDMATIMAGLACGE 293 Query: 242 -SSIGLNTWPIIRDLVDDIFTVTEDEIKCATQLV 274 + +G W I+R+ CATQ + Sbjct: 294 PNPLG---WEILRN--------------CATQFI 310 >5XEM-A nrPDB Length = 310 Score = 35.0 bits (79), Expect = 0.045, Method: Compositional matrix adjust. Identities = 63/253 (24%), Positives = 104/253 (41%), Gaps = 20/253 (7%) Query: 21 DSIHLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVRSLVPDALERKPKAVV 80 D I TP++ + ++ G ++ K E S K R AL + + L K ++ Sbjct: 12 DLIGNTPLVKINNIDTF-GNEIYVKLEGSNPGRSTKDRIALKMIEEAEKEGLIDKDTVII 70 Query: 81 THSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYCEPSDESRENVAK 140 +SGN G L ++ IV+P T + ++AYG ++ + S + + K Sbjct: 71 EATSGNTGIGLAMICAVKNYKLKIVMPDTMSIERIQLMRAYGTEVILTDGSLGMKACLEK 130 Query: 141 -RVTEETEGIMVHPNQEPAV---IAGQGTIALEVLNQV-PLVDALVVPVGGGGMLAGIAI 195 ++ E PNQ V A T A E+L + VD + G GG +G A Sbjct: 131 LEELKKNEKKYFVPNQFTNVNNPKAHYETTAEEILKDLNNKVDVFICGTGTGGSFSGTAK 190 Query: 196 TVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGVKSSIGLNTWPIIRD- 254 +K P++K + EP+++ L+ Y G+ SIG P + D Sbjct: 191 KLKEKLPNIKTFPVEPASS----------PLLSKGYIGPHKIQGMGMSIG--GIPAVYDG 238 Query: 255 -LVDDIFTVTEDE 266 L DDI +D+ Sbjct: 239 SLADDILVCEDDD 251 >4LMA-A nrPDB Length = 326 Score = 34.3 bits (77), Expect = 0.071, Method: Compositional matrix adjust. Identities = 52/194 (26%), Positives = 89/194 (45%), Gaps = 19/194 (9%) Query: 79 VVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYCEPSDESRENV 138 +V +SGN G AL A +G + +P+T ++ ++AYGA++ P + + Sbjct: 77 LVEPTSGNTGIALAMTAAAKGYRLILTMPETMSLERRAMLKAYGATLELT-PGSQGMKGA 135 Query: 139 AKRVTEETEGI----MVHPNQEPAVIA-GQGTIALEVLNQVP-LVDALVVPVGGGGMLAG 192 R + + I M+ + P+ + T A E+ VD +V VG GG + G Sbjct: 136 ILRAQQIVDSIPGAYMLQQFRNPSNPEIHRLTTAEEIWQDTEGQVDFIVAGVGTGGTITG 195 Query: 193 IAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGVKSSIGLNTWPII 252 +A +K+ KPS +V A EP N+ P + + I G + L T Sbjct: 196 VAEVIKSRKPSFQVVAVEPFNSPVISGGN------PGPHKIQGIGAGFIPEV-LRT---- 244 Query: 253 RDLVDDIFTVTEDE 266 DL+D++ TV+++E Sbjct: 245 -DLIDEVITVSDEE 257 >5EY5-B nrPDB Length = 399 Score = 33.5 bits (75), Expect = 0.13, Method: Compositional matrix adjust. Identities = 47/198 (23%), Positives = 80/198 (40%), Gaps = 28/198 (14%) Query: 19 IRDSIHL-TPV-LTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVRSLVPDALERKP 76 +RD + TP+ ++ L G ++ K E TG+ KI AL ++L+ + +K Sbjct: 43 LRDYVGRPTPLYFAENLTKDLGGAKIYLKREDLNHTGAHKINNALG--QALLAKRMGKK- 99 Query: 77 KAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYCE--PSDES 134 + + +G HG A A + G+ VV A D ++ A+ + ++ + P Sbjct: 100 RVIAETGAGQHGVATATVAAMFGLEC--VVYMGAEDIERQALNVFRMKLLGAKVRPVTSG 157 Query: 135 RENVAKRVTEETE-------------GIMVHPNQEPAVIAG-QGTIALEVLNQV-----P 175 + + E G +V P+ P ++ Q I E Q+ Sbjct: 158 SRTLKDAINEAMRDWVTNVEDTFYIIGSVVGPHPYPMMVRDFQSVIGEEARQQILEKEGR 217 Query: 176 LVDALVVPVGGGGMLAGI 193 L DA+V VGGG GI Sbjct: 218 LPDAIVACVGGGSNAMGI 235 >5XA2-A nrPDB Length = 309 Score = 33.1 bits (74), Expect = 0.16, Method: Compositional matrix adjust. Identities = 71/272 (26%), Positives = 118/272 (43%), Gaps = 53/272 (19%) Query: 24 HLTPVLTSSILNQLTGRNLFF--KCELFQKTGSFKIRGALNAVRSLVPDALER---KPKA 78 LT L+S +L ++ GRN + KC + GA +++ DA + KP Sbjct: 21 RLTAGLSSRVLAKIEGRNPAYSVKCRI----------GA-----AMIWDAEQSGKLKPGM 65 Query: 79 -VVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYCEPSDESREN 137 VV +SGN G AL + G + +P+T +++ ++++GA +V +D + Sbjct: 66 HVVEPTSGNTGIALAFVCAARGYKLTLTMPETMSIERRMMLKSFGADLVLTPGADGMKGA 125 Query: 138 VAKRVTEETEGIMVHPNQ-----EPAVIAGQGTIALEVLNQVP-LVDALVVPVGGGGMLA 191 ++K + P Q PA+ T E+ N VD V VG GG + Sbjct: 126 ISKAEELAAQPGWFIPQQFKNPANPAIHVK--TTGPEIWNDTEGQVDVFVAGVGTGGTIT 183 Query: 192 GIAITVKALKPS-VKVYAAEPSNA-----DDCYQSKLKGKLMPNLYPPETIADGVKSSIG 245 G+A +K K V V A EP+ + + K++G + + P+T Sbjct: 184 GVARFLKHEKKHPVHVVAVEPAASPVLAGGPAGRHKIQG--IGAGFVPDTFD-------- 233 Query: 246 LNTWPIIRDLVDDIFTVTEDE-IKCATQLVWE 276 R +VD+I +VT+DE I+ A +L E Sbjct: 234 -------RSVVDEILSVTDDEAIETARKLAME 258 >4LMB-A nrPDB Length = 322 Score = 32.0 bits (71), Expect = 0.40, Method: Compositional matrix adjust. Identities = 52/184 (28%), Positives = 78/184 (42%), Gaps = 14/184 (7%) Query: 41 NLFFKCELFQKTGSFKIRGALNAVRSLVPDALERKPKAVVTH-SSGNHGQALTYAAKLEG 99 + K E S K R ++ V L K ++ +SGN G AL A +G Sbjct: 38 RIVVKLESMNPAASVKDRIGVSMVEDAEAAGLIHPDKTILVEPTSGNTGIALAMVAAAKG 97 Query: 100 IPAYIVVPQTAPDCKKLAIQAYGASIVYCEPSDESRENVAKRVTEETEGIMVHPN----- 154 + +P+T ++ ++AYGA + P + E R E E PN Sbjct: 98 YRLVLTMPETMSLERRAMLKAYGAQLELT-PGSQGMEGAITRAEEIVENT---PNAYSLQ 153 Query: 155 --QEPAVIA-GQGTIALEVLNQVP-LVDALVVPVGGGGMLAGIAITVKALKPSVKVYAAE 210 + PA + T A E+ LVD ++ VG GG + GIA T+K +P + A E Sbjct: 154 QFRNPANPKIHRETTAEEIWADTDGLVDIVIGGVGTGGTITGIAETIKPRRPQFQAIAVE 213 Query: 211 PSNA 214 PSN+ Sbjct: 214 PSNS 217 >4AEC-A nrPDB Length = 430 Score = 31.6 bits (70), Expect = 0.49, Method: Compositional matrix adjust. Identities = 28/119 (23%), Positives = 55/119 (46%), Gaps = 9/119 (7%) Query: 18 NIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVRSLVPDALER--- 74 N+ I TP++ + + + N+ K E+ + S K R S+V DA ++ Sbjct: 116 NVSQLIGKTPMVYLNSIAKGCVANIAAKLEIMEPCCSVKDRIGY----SMVTDAEQKGFI 171 Query: 75 --KPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYCEPS 131 +V +SGN G L + A G + +P + +++ ++A+GA +V +P+ Sbjct: 172 SPGKSVLVEPTSGNTGIGLAFIAASRGYRLILTMPASMSMERRVLLKAFGAELVLTDPA 230 >1X1Q-A nrPDB Length = 418 Score = 31.6 bits (70), Expect = 0.54, Method: Compositional matrix adjust. Identities = 42/186 (22%), Positives = 79/186 (42%), Gaps = 31/186 (16%) Query: 26 TPVLTSSILNQL-TGRNLFFKCELFQKTGSFKIRGALNAVRSLVPDALERKPKAVVTHSS 84 TP+ + L++ G +F K E TG+ KI L ++L+ + ++ + + + Sbjct: 78 TPLYHAKRLSEYWGGAQVFLKREDLLHTGAHKINNTLG--QALLARRMGKR-RVIAETGA 134 Query: 85 GNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYCEP----------SDES 134 G HG ++ A L G+ VV D ++ A+ + ++ E D + Sbjct: 135 GQHGVSVATVAALFGLEC--VVYMGEEDVRRQALNVFRMKLLGAEVRPVAAGSRTLKDAT 192 Query: 135 RENVAK-----RVTEETEGIMVHPNQEPAVIAGQGTI--------ALEVLNQVPLVDALV 181 E + R T G +V P+ P ++ ++ +LE+ ++P DAL+ Sbjct: 193 NEAIRDWITNVRTTFYILGSVVGPHPYPMMVRDFQSVIGEEVKRQSLELFGRLP--DALI 250 Query: 182 VPVGGG 187 VGGG Sbjct: 251 AAVGGG 256 >5KIN-B nrPDB Length = 407 Score = 30.8 bits (68), Expect = 0.85, Method: Compositional matrix adjust. Identities = 51/191 (26%), Positives = 77/191 (40%), Gaps = 28/191 (14%) Query: 26 TPVLTSSILNQ-LTGRNLFFKCELFQKTGSFKIRGALNAVRSLVPDALERKPKAVVTHSS 84 TP+ + L Q + G ++ K E TG+ KI AL V + + +K K + + Sbjct: 60 TPLYYAKNLTQHIGGAKIYLKREDLNHTGAHKINNALGQV--WLAKRMGKK-KIIAETGA 116 Query: 85 GNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYCEP---SDESRE----- 136 G HG A AA L + I + + D K+ A+ + ++ + +D SR Sbjct: 117 GQHGVATATAAALFNMECTIYMGEE--DVKRQALNVFRMELLGAKVEAVTDGSRVLKDAV 174 Query: 137 NVAKRV-------TEETEGIMVHPNQEPAVIAG-QGTIALEVLNQV------PLVDALVV 182 N A R T G + P+ P ++ Q I E Q L DALV Sbjct: 175 NAALRSWVANIDDTHYILGSALGPHPFPEIVRDFQSVIGREAKQQYRDLTGRDLPDALVA 234 Query: 183 PVGGGGMLAGI 193 VGGG G+ Sbjct: 235 CVGGGSNAIGL 245 >3JYN-A nrPDB Length = 325 Score = 30.4 bits (67), Expect = 1.3, Method: Compositional matrix adjust. Identities = 55/212 (25%), Positives = 89/212 (41%), Gaps = 26/212 (12%) Query: 49 FQKTGSFKIRGALNAVRSLVPDALERKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQ 108 F++ + ++G V+ L+ + KP ++ + G + + A ++ Sbjct: 115 FEQAAALMLKGL--TVQYLLRQTYQVKPGEIILFHAAAGGVGSLACQWAKALGAKLIGTV 172 Query: 109 TAPDCKKLAIQAYGASIVYCEPSDESRENVAKRVTEETEGIMVHPNQEPAVIAGQGT-IA 167 ++P+ K +A GA E D S E+VAKRV E T+G + P V G G Sbjct: 173 SSPE-KAAHAKALGA----WETIDYSHEDVAKRVLELTDG-----KKCPVVYDGVGQDTW 222 Query: 168 LEVLNQVPLVDALVVPVGGG-GMLAGIAITVKALKPSVKV-------YAAEPSN----AD 215 L L+ V LVV G G ++G+ + + A K SV V YA N AD Sbjct: 223 LTSLDSVA-PRGLVVSFGNASGPVSGVNLGILAQKDSVYVTRPTLGSYANNAQNLQTMAD 281 Query: 216 DCYQSKLKGKLMPNLYPPETIADGVKSSIGLN 247 + + GKL + + D K+ I L+ Sbjct: 282 ELFDMLASGKLKVDGIEQYALKDAAKAQIELS 313 >4ZW2-A nrPDB Length = 333 Score = 30.0 bits (66), Expect = 1.6, Method: Compositional matrix adjust. Identities = 12/29 (41%), Positives = 16/29 (55%) Query: 83 SSGNHGQALTYAAKLEGIPAYIVVPQTAP 111 SS HG+ + + K E +P Y VVP P Sbjct: 119 SSSKHGKRIPFFKKTEHVPPYDVVPSMRP 147 >5BPF-A nrPDB Length = 306 Score = 29.6 bits (65), Expect = 1.8, Method: Compositional matrix adjust. Identities = 16/43 (37%), Positives = 23/43 (53%), Gaps = 5/43 (11%) Query: 268 KCATQLVWERMKLLIEPTAGVGVAAVLSQHFQTVSPEVKNICI 310 K T+LVW+ + L I P A+ Q F+T+SPE C+ Sbjct: 97 KLRTKLVWQALGLPISP-----YVALNRQQFETLSPEELVACV 134 >3T4P-A nrPDB Length = 334 Score = 29.3 bits (64), Expect = 2.6, Method: Compositional matrix adjust. Identities = 13/48 (27%), Positives = 26/48 (54%) Query: 79 VVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIV 126 VV SSGN G +L + + G I +P++ ++ ++ +GA ++ Sbjct: 75 VVESSSGNTGVSLAHLGAIRGYKVIITMPESMSLERRCLLRIFGAEVI 122 >5OCW-B nrPDB Length = 442 Score = 29.3 bits (64), Expect = 2.6, Method: Compositional matrix adjust. Identities = 47/188 (25%), Positives = 77/188 (40%), Gaps = 23/188 (12%) Query: 26 TPVLTSSILNQLTGR-NLFFKCELFQKTGSFKIRGALNAVRSLVPDALERKPKAVVTHSS 84 +P+ ++ L+Q G +F K E TGS KI L ++L+ + K + + + Sbjct: 102 SPLYEATRLSQHAGSARIFLKREDLNHTGSHKINNVLG--QALLARRMG-KTRVIAETGA 158 Query: 85 GNHGQALTYAAKLEGIPAYIVVP--QTAPDCKKLA-IQAYGASIVYCEPSDESRENVAKR 141 G HG A A L G+ I + TA +A ++ GA +V + ++ ++ Sbjct: 159 GQHGVATATACALLGLDCVIYMGGIDTARQALNVARMRLLGAEVVAVQTGSKTLKDAINE 218 Query: 142 V----------TEETEGIMVHPNQEPAVIAG-QGTIALEVLNQVP-----LVDALVVPVG 185 T G P+ P ++ Q I +E Q+ L DA+V VG Sbjct: 219 AFRDWVANADNTYYCFGTAAGPHPFPTMVRDFQRIIGMEARVQIQGQAGRLPDAVVACVG 278 Query: 186 GGGMLAGI 193 GG GI Sbjct: 279 GGSNAIGI 286 >4L16-A nrPDB Length = 334 Score = 28.1 bits (61), Expect = 5.1, Method: Compositional matrix adjust. Identities = 12/34 (35%), Positives = 21/34 (61%) Query: 252 IRDLVDDIFTVTEDEIKCATQLVWERMKLLIEPT 285 IRD+ DDI T+ +D+I+ T + + ++ PT Sbjct: 275 IRDIGDDIETIDKDDIRAVTVMDFAEAARVVRPT 308 >1VQ2-A nrPDB Length = 193 Score = 28.1 bits (61), Expect = 5.5, Method: Compositional matrix adjust. Identities = 16/51 (31%), Positives = 27/51 (52%), Gaps = 5/51 (9%) Query: 89 QALTYAAK----LEGIPAYIVVPQTAPDCKKLAIQAYGASIVYCEPSDESR 135 A+ +AA+ +EG Y+ + PDC K Q+ +VYCE D+++ Sbjct: 108 NAILFAAENGSSIEGATMYVTL-SPCPDCAKAIAQSGIKKLVYCETYDKNK 157 >1J0B-A nrPDB Length = 325 Score = 27.7 bits (60), Expect = 6.7, Method: Compositional matrix adjust. Identities = 49/188 (26%), Positives = 74/188 (39%), Gaps = 29/188 (15%) Query: 53 GSFKIRGALNAVRSLVPDALERKPKAVVT----HSSGNHGQALTYAAKLEGIPAYIVVPQ 108 G KIR + L+ DAL + V+T HS NH AAK G+ A I+V + Sbjct: 51 GGNKIR----KLEYLLGDALSKGADVVITVGAVHS--NHAFVTGLAAKKLGLDA-ILVLR 103 Query: 109 TAPDCKK--LAIQAYG-ASIVYCEPSDESRENVAKRVTEETEGIMVHPNQEPAVIAGQGT 165 + K L + G + VY A+ + EE + ++P VI G Sbjct: 104 GKEELKGNYLLDKIMGIETRVYDAKDSFELMKYAEEIAEE----LKREGRKPYVIPPGGA 159 Query: 166 IALEVLNQVPLV-----------DALVVPVGGGGMLAGIAITVKALKPSVKVYAAEPSNA 214 + L V V D++VV G GG LAG+++ + L ++ Sbjct: 160 SPIGTLGYVRAVGEIATQSEVKFDSIVVAAGSGGTLAGLSLGLSILNEDIRPVGIAVGRF 219 Query: 215 DDCYQSKL 222 + SKL Sbjct: 220 GEVMTSKL 227 >3IYS-A nrPDB Length = 343 Score = 27.7 bits (60), Expect = 7.0, Method: Compositional matrix adjust. Identities = 13/33 (39%), Positives = 21/33 (63%), Gaps = 3/33 (9%) Query: 265 DEIKCATQLVWERMKLLIEPTAGVGVAAVLSQH 297 D+I C T L+WE + + E VGV+++L+ H Sbjct: 88 DDITCPTLLMWEAVSVKTEV---VGVSSILNMH 117 >4D9F-A nrPDB Length = 342 Score = 27.3 bits (59), Expect = 9.7, Method: Compositional matrix adjust. Identities = 48/202 (23%), Positives = 81/202 (40%), Gaps = 26/202 (12%) Query: 26 TPVLTSSILNQLTGRNLFFKCELFQ--KTGSFKIRGALNAVRSLVPDALERKPKAVVTHS 83 TP+ L+ GR ++ K + G K+R + LV DAL ++T Sbjct: 33 TPLEYLPRLSDYLGREIYIKRDDVTPIAMGGNKLR----KLEFLVADALREGADTLITAG 88 Query: 84 S--GNH-GQALTYAAKLEGI--------PAYIVVPQTAPDCKKLAIQAYGASIVYCEP-- 130 + NH Q AAKL G+ P + +L + + I C+ Sbjct: 89 AIQSNHVRQTAAVAAKL-GLHCVALLENPIGTTAENYLTNGNRLLLDLFNTQIEMCDALT 147 Query: 131 -SDESRENVAKRVTEETEGIMVHPNQEPAVIAGQGTI--ALEVLNQ---VPLVDALVVPV 184 D + +A R+ + V P + + G + ALE+ Q V + ++VV Sbjct: 148 DPDAQLQTLATRIEAQGFRPYVIPVGGSSALGAMGYVESALEIAQQCEEVVGLSSVVVAS 207 Query: 185 GGGGMLAGIAITVKALKPSVKV 206 G G AG+A+ ++ L P V++ Sbjct: 208 GSAGTHAGLAVGLEHLMPDVEL 229 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 5X2L-A nrPDB 444 e-125 3L6C-A nrPDB 392 e-110 5YBW-A nrPDB 300 8e-82 1V71-A nrPDB 288 2e-78 5CVC-A nrPDB 275 1e-74 4COO-A nrPDB 271 2e-73 1M54-A nrPDB 270 6e-73 5MMS-A nrPDB 269 1e-72 5OHX-A nrPDB 263 8e-71 1TDJ-A nrPDB 262 1e-70 3IAU-A nrPDB 260 7e-70 2GN1-A nrPDB 254 4e-68 1VE5-A nrPDB 250 7e-67 3FCA-A nrPDB 246 8e-66 5C3U-A nrPDB 246 8e-66 2EFY-A nrPDB 246 9e-66 2JC3-A nrPDB 246 1e-65 2BHS-A nrPDB 245 2e-65 6AHI-A nrPDB 238 3e-63 6C2H-A nrPDB 238 4e-63 3PC3-A nrPDB 238 4e-63 2Q3D-A nrPDB 232 2e-61 4OFX-A nrPDB 231 3e-61 5JJC-A nrPDB 230 6e-61 2PQM-A nrPDB 229 1e-60 5XW3-A nrPDB 227 7e-60 6NMX-A nrPDB 225 2e-59 1PWH-A nrPDB 224 3e-59 4I1Y-A nrPDB 224 4e-59 3VBE-A nrPDB 222 2e-58 2EGU-A nrPDB 221 5e-58 3X43-A nrPDB 216 2e-56 4H27-A nrPDB 215 2e-56 2RKB-A nrPDB 204 6e-53 5D84-A nrPDB 201 4e-52 5I7O-A nrPDB 199 9e-52 5B1I-A nrPDB 192 2e-49 5B55-A nrPDB 182 2e-46 2ZSJ-A nrPDB 172 2e-43 2D1F-A nrPDB 170 6e-43 5YGR-A nrPDB 163 1e-40 1UIN-A nrPDB 162 1e-40 Sequences not found previously or not previously below threshold: 5XA2-A nrPDB 218 4e-57 4LMA-A nrPDB 215 2e-56 4AEC-A nrPDB 213 8e-56 5J5V-A nrPDB 209 1e-54 5XEM-A nrPDB 209 2e-54 2ISQ-A nrPDB 204 3e-53 4LMB-A nrPDB 203 1e-52 3T4P-A nrPDB 185 2e-47 5XCN-X nrPDB 177 5e-45 4D9G-A nrPDB 132 1e-31 3VSD-A nrPDB 120 8e-28 1E5X-A nrPDB 110 9e-25 6HUL-B nrPDB 101 5e-22 5EY5-B nrPDB 88 5e-18 5OCW-B nrPDB 85 4e-17 4NEG-A nrPDB 85 4e-17 4D9F-A nrPDB 84 9e-17 5KIN-B nrPDB 82 3e-16 6AMI-A nrPDB 81 9e-16 5KZM-B nrPDB 79 2e-15 1X1Q-A nrPDB 79 2e-15 3SS9-X nrPDB 77 9e-15 1CX9-B nrPDB 77 1e-14 3R0X-A nrPDB 74 1e-13 1J0B-A nrPDB 72 3e-13 1RQX-A nrPDB 67 8e-12 6EQN-B nrPDB 62 3e-10 1VB3-A nrPDB 59 3e-09 3V7N-A nrPDB 39 0.002 1KL7-A nrPDB 34 0.068 2VCY-A nrPDB 34 0.093 3IP1-A nrPDB 32 0.38 1T8T-A nrPDB 32 0.44 5ZLR-A nrPDB 31 0.68 2H6E-A nrPDB 31 0.69 3OM8-A nrPDB 31 0.74 3NXS-A nrPDB 31 0.78 5W8S-A nrPDB 30 1.2 3E7W-A nrPDB 30 1.3 1WCV-1 nrPDB 30 1.3 4G5X-A nrPDB 30 1.7 6HLX-A nrPDB 30 1.7 1SEZ-A nrPDB 30 1.8 4WW4-B nrPDB 30 1.8 5OC1-A nrPDB 29 2.3 3GDF-A nrPDB 29 2.5 4W8I-A nrPDB 29 2.9 4TLZ-A nrPDB 29 3.0 2DFV-A nrPDB 29 3.2 1DXH-A nrPDB 29 3.4 3TK1-A nrPDB 29 3.7 3NJR-A nrPDB 29 3.7 2WOV-A nrPDB 29 3.7 3JSK-A nrPDB 29 3.8 6B6X-A nrPDB 29 4.3 4MUZ-A nrPDB 29 4.6 4JBE-A nrPDB 29 4.7 2BR3-A nrPDB 28 5.4 5JFC-L nrPDB 28 5.8 1L3B-A nrPDB 28 6.5 5EB4-A nrPDB 28 7.6 3AOE-E nrPDB 28 7.6 2YAU-A nrPDB 28 8.0 4R16-A nrPDB 27 9.5 >5X2L-A nrPDB Length = 348 Score = 444 bits (1142), Expect = e-125, Method: Composition-based stats. Identities = 340/340 (100%), Positives = 340/340 (100%) Query: 1 MCAQYCISFADVEKAHINIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGA 60 MCAQYCISFADVEKAHINIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGA Sbjct: 1 MCAQYCISFADVEKAHINIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGA 60 Query: 61 LNAVRSLVPDALERKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQA 120 LNAVRSLVPDALERKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQA Sbjct: 61 LNAVRSLVPDALERKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQA 120 Query: 121 YGASIVYCEPSDESRENVAKRVTEETEGIMVHPNQEPAVIAGQGTIALEVLNQVPLVDAL 180 YGASIVYCEPSDESRENVAKRVTEETEGIMVHPNQEPAVIAGQGTIALEVLNQVPLVDAL Sbjct: 121 YGASIVYCEPSDESRENVAKRVTEETEGIMVHPNQEPAVIAGQGTIALEVLNQVPLVDAL 180 Query: 181 VVPVGGGGMLAGIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGV 240 VVPVGGGGMLAGIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGV Sbjct: 181 VVPVGGGGMLAGIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGV 240 Query: 241 KSSIGLNTWPIIRDLVDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQT 300 KSSIGLNTWPIIRDLVDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQT Sbjct: 241 KSSIGLNTWPIIRDLVDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQT 300 Query: 301 VSPEVKNICIVLSGGNVDLTSSITWVKQAERPASYQSVSV 340 VSPEVKNICIVLSGGNVDLTSSITWVKQAERPASYQSVSV Sbjct: 301 VSPEVKNICIVLSGGNVDLTSSITWVKQAERPASYQSVSV 340 >3L6C-A nrPDB Length = 339 Score = 392 bits (1008), Expect = e-110, Method: Composition-based stats. Identities = 302/333 (90%), Positives = 321/333 (96%), Gaps = 1/333 (0%) Query: 1 MCAQYCISFADVEKAHINIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGA 60 M AQY ISFADVEKAH+NI+DS+HLTPVLTSSILNQ+ GRNLFFKCELFQKTGSFKIRGA Sbjct: 1 MDAQYDISFADVEKAHLNIQDSVHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGA 60 Query: 61 LNAVRSLVPDALERKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQA 120 LNA+R L+PD LE KPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAP+CKKLAIQA Sbjct: 61 LNAIRGLIPDTLEGKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPNCKKLAIQA 120 Query: 121 YGASIVYCEPSDESRENVAKRVTEETEGIMVHPNQEPAVIAGQGTIALEVLNQVPLVDAL 180 YGASIVY EPSDESRENVA+R+ +ETEGI+VHPNQEPAVIAGQGTIALEVLNQVPLVDAL Sbjct: 121 YGASIVYSEPSDESRENVAQRIIQETEGILVHPNQEPAVIAGQGTIALEVLNQVPLVDAL 180 Query: 181 VVPVGGGGMLAGIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGV 240 VVPVGGGGM+AGIAIT+K LKPSVKVYAAEPSNADDCYQSKLKG+L PNL+PPETIADGV Sbjct: 181 VVPVGGGGMVAGIAITIKTLKPSVKVYAAEPSNADDCYQSKLKGELTPNLHPPETIADGV 240 Query: 241 KSSIGLNTWPIIRDLVDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQT 300 KSSIGLNTWPIIRDLVDD+FTVTEDEIK ATQLVWERMKLLIEPTAGVG+AAVLSQHFQT Sbjct: 241 KSSIGLNTWPIIRDLVDDVFTVTEDEIKYATQLVWERMKLLIEPTAGVGLAAVLSQHFQT 300 Query: 301 VSPEVKNICIVLSGGNVDLTSSITWVKQAERPA 333 VSPEVKNICIVLSGGNVDLTS ++WVKQAERPA Sbjct: 301 VSPEVKNICIVLSGGNVDLTS-LSWVKQAERPA 332 >5YBW-A nrPDB Length = 329 Score = 300 bits (767), Expect = 8e-82, Method: Composition-based stats. Identities = 137/324 (42%), Positives = 189/324 (58%), Gaps = 9/324 (2%) Query: 4 QYCISFADVEKAHINIRDSIHLTPVLTSSILNQL----TGRNLFFKCELFQKTGSFKIRG 59 Q+ ++ D++KA+ I I TPV TS +++ GR +FK E QKTGSFK RG Sbjct: 3 QFEVTVTDIKKAYDRISKHILYTPVFTSPTFDRMVGSKAGRQFYFKAENLQKTGSFKARG 62 Query: 60 ALNAVRSLVPDALERKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQ 119 ALNA+ L E VVTHSSGNHGQAL +A+K G+ +VVP+TAP K A++ Sbjct: 63 ALNAI--LCALEREPSLAGVVTHSSGNHGQALAWASKRAGVKCCVVVPKTAPQVKFDAME 120 Query: 120 AYGASIVYCEPSDESRENVAKRVTEETEGIMVHPNQEPAVIAGQGTIALEVLNQVPLVDA 179 YGA +V CEP+ SR+ + + + + + + VIAGQGTIALE+L Q P +DA Sbjct: 121 NYGAEVVKCEPNPTSRKETCEGLAKSRGYKYISSSDDYDVIAGQGTIALELLQQQPDLDA 180 Query: 180 LVVPVGGGGMLAGIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYP-PETIAD 238 ++V V GGM +GI + K K +KV+ EP + +L PN +TIAD Sbjct: 181 ILVSVSAGGMASGICVYTKNTKSDLKVFLVEPEGKMLEECISKRERLWPNPPQFLDTIAD 240 Query: 239 G-VKSSIGLNTWPIIRDLVD-DIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQ 296 G + G TWPII +L + ++ TV D I A + V+ RMKL+IE AG VAA +++ Sbjct: 241 GIILQQCGNKTWPIILELPEKEVITVNNDNIVEAMRFVFARMKLVIEAAAGATVAAAMTE 300 Query: 297 HFQTVSPEVKNICIVLSGGNVDLT 320 FQ PE K + I+L GGNVD+ Sbjct: 301 RFQNFHPEAKKVGIILCGGNVDIE 324 >1V71-A nrPDB Length = 323 Score = 288 bits (738), Expect = 2e-78, Method: Composition-based stats. Identities = 125/322 (38%), Positives = 191/322 (59%), Gaps = 8/322 (2%) Query: 8 SFADVEKAHINIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVRSL 67 ++ DV A I+ + TPVLTSS +N+ +FFKCE FQK G+FK RGALNA+ L Sbjct: 9 TYDDVASASERIKKFANKTPVLTSSTVNKEFVAEVFFKCENFQKMGAFKFRGALNALSQL 68 Query: 68 VPDALERKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVY 127 ++ V+T SSGNH QA+ +AK+ GIPA I++P AP+ K A + YG ++ Sbjct: 69 NE---AQRKAGVLTFSSGNHAQAIALSAKILGIPAKIIMPLDAPEAKVAATKGYGGQVIM 125 Query: 128 CEPSDESRENVAKRVTEETEGIMVHPNQEPAVIAGQGTIALEVLNQVPLVDALVVPVGGG 187 + + RE +AK ++E ++ P P V+AGQGT A E+ +V +DAL V +GGG Sbjct: 126 YDRYKDDREKMAKEISEREGLTIIPPYDHPHVLAGQGTAAKELFEEVGPLDALFVCLGGG 185 Query: 188 GMLAGIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGVKSS-IGL 246 G+L+G A+ + P+ +VY EP +D QS KG ++ ++ P+TIADG ++ +G Sbjct: 186 GLLSGSALAARHFAPNCEVYGVEPEAGNDGQQSFRKGSIV-HIDTPKTIADGAQTQHLGN 244 Query: 247 NTWPIIRDLVDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQTVSPEVK 306 T+ II++ VDDI TV+++E+ + RMK+++EPT + AA + K Sbjct: 245 YTFSIIKEKVDDILTVSDEELIDCLKFYAARMKIVVEPTGCLSFAAA---RAMKEKLKNK 301 Query: 307 NICIVLSGGNVDLTSSITWVKQ 328 I I++SGGNVD+ ++ Q Sbjct: 302 RIGIIISGGNVDIERYAHFLSQ 323 >5CVC-A nrPDB Length = 346 Score = 275 bits (704), Expect = 1e-74, Method: Composition-based stats. Identities = 145/320 (45%), Positives = 213/320 (66%), Gaps = 6/320 (1%) Query: 5 YCISFADVEKAHINIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAV 64 Y + +A I +H TPV++S+ ++ + G+ LFFKCE FQK G+FKIRGA N++ Sbjct: 16 YAADIDSIREAQARIAPYVHRTPVMSSTSIDAMVGKKLFFKCECFQKAGAFKIRGASNSI 75 Query: 65 RSLVPDALERKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGAS 124 +L E+ K VVTHSSGNH A+ AAKL GIPA+IV+P+ AP K ++ YG Sbjct: 76 FALDD---EQVSKGVVTHSSGNHAAAVALAAKLRGIPAHIVIPRNAPASKVENVKCYGGH 132 Query: 125 IVYCEPSDESRENVAKRVTEETEGIMVHPNQEPAVIAGQGTIALEVLNQVPLVDALVVPV 184 I++ + S ESRE V+KRV EET +++HP I+GQGT++LE+L QVP +D ++VP+ Sbjct: 133 IIWSDASIESREYVSKRVQEETGAVLIHPINSKYTISGQGTVSLELLEQVPEIDTIIVPI 192 Query: 185 GGGGMLAGIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGVKSSI 244 GGG+++G+A+ KA+ PS+++ AAEP ADD QSK GK++ L TIADG+++ + Sbjct: 193 SGGGLISGVALAAKAINPSIRILAAEPKGADDSAQSKAAGKIIT-LPSTNTIADGLRAFL 251 Query: 245 GLNTWPIIRDLVDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQTVSP- 303 G TWP++RDLVDD+ V + I A ++ +E +K+ +EP+ +G+AA LS F+ S Sbjct: 252 GDLTWPVVRDLVDDVIVVDDTAIVDAMKMCYEILKVAVEPSGAIGLAAALSDEFKQSSAW 311 Query: 304 -EVKNICIVLSGGNVDLTSS 322 E I I++SGGNVDL + Sbjct: 312 HESSKIGIIVSGGNVDLGTL 331 >4COO-A nrPDB Length = 563 Score = 271 bits (694), Expect = 2e-73, Method: Composition-based stats. Identities = 75/309 (24%), Positives = 120/309 (38%), Gaps = 23/309 (7%) Query: 19 IRDSIHLTPVLTSSILNQLTG--RNLFFKCELFQKTGSFKIRGALNAVRSLVPDALERKP 76 I I TP++ + + + G L KCE F GS K R +L + D + Sbjct: 102 ILKKIGDTPMVRINKIGKKFGLKCELLAKCEFFNAGGSVKDRISLRMIEDAERDGTLKPG 161 Query: 77 KAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYCEPS----- 131 ++ +SGN G L AA + G IV+P+ K ++A GA IV + Sbjct: 162 DTIIEPTSGNTGIGLALAAAVRGYRCIIVMPEKMSSEKVDVLRALGAEIVRTPTNARFDS 221 Query: 132 DESRENVAKRVTEETEG-IMVHPNQEPAV-IAGQGTIALEVLNQVP-LVDALVVPVGGGG 188 ES VA R+ E ++ + + +A T A E+L Q +D LV VG GG Sbjct: 222 PESHVGVAWRLKNEIPNSHILDQYRNASNPLAHYDTTADEILQQCDGKLDMLVASVGTGG 281 Query: 189 MLAGIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGVKSSIGLNT 248 + GIA +K P ++ +P + P IG + Sbjct: 282 TITGIARKLKEKCPGCRIIGVDPEGSILAE---------PEELNQTEQTTYEVEGIGYDF 332 Query: 249 WPII--RDLVDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQTVSPEVK 306 P + R +VD F ++E +++ + LL +AG VA + E + Sbjct: 333 IPTVLDRTVVDKWFKSNDEEAFTFARMLIAQEGLLCGGSAGSTVAVAVK--AAQELQEGQ 390 Query: 307 NICIVLSGG 315 ++L Sbjct: 391 RCVVILPDS 399 >1M54-A nrPDB Length = 363 Score = 270 bits (690), Expect = 6e-73, Method: Composition-based stats. Identities = 75/309 (24%), Positives = 120/309 (38%), Gaps = 23/309 (7%) Query: 19 IRDSIHLTPVLTSSILNQLTG--RNLFFKCELFQKTGSFKIRGALNAVRSLVPDALERKP 76 I I TP++ + + + G L KCE F GS K R +L + D + Sbjct: 37 ILKKIGDTPMVRINKIGKKFGLKCELLAKCEFFNAGGSVKDRISLRMIEDAERDGTLKPG 96 Query: 77 KAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYCEPS----- 131 ++ +SGN G L AA + G IV+P+ K ++A GA IV + Sbjct: 97 DTIIEPTSGNTGIGLALAAAVRGYRCIIVMPEKMSSEKVDVLRALGAEIVRTPTNARFDS 156 Query: 132 DESRENVAKRVTEETEG-IMVHPNQEPAV-IAGQGTIALEVLNQVP-LVDALVVPVGGGG 188 ES VA R+ E ++ + + +A T A E+L Q +D LV VG GG Sbjct: 157 PESHVGVAWRLKNEIPNSHILDQYRNASNPLAHYDTTADEILQQCDGKLDMLVASVGTGG 216 Query: 189 MLAGIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGVKSSIGLNT 248 + GIA +K P ++ +P + P IG + Sbjct: 217 TITGIARKLKEKCPGCRIIGVDPEGSILAE---------PEELNQTEQTTYEVEGIGYDF 267 Query: 249 WPII--RDLVDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQTVSPEVK 306 P + R +VD F ++E +++ + LL +AG VA + E + Sbjct: 268 IPTVLDRTVVDKWFKSNDEEAFTFARMLIAQEGLLCGGSAGSTVAVAVK--AAQELQEGQ 325 Query: 307 NICIVLSGG 315 ++L Sbjct: 326 RCVVILPDS 334 >5MMS-A nrPDB Length = 408 Score = 269 bits (688), Expect = 1e-72, Method: Composition-based stats. Identities = 75/309 (24%), Positives = 120/309 (38%), Gaps = 23/309 (7%) Query: 19 IRDSIHLTPVLTSSILNQLTG--RNLFFKCELFQKTGSFKIRGALNAVRSLVPDALERKP 76 I I TP++ + + + G L KCE F GS K R +L + D + Sbjct: 80 ILKKIGDTPMVRINKIGKKFGLKCELLAKCEFFNAGGSVKDRISLRMIEDAERDGTLKPG 139 Query: 77 KAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYCEPS----- 131 ++ +SGN G L AA + G IV+P+ K ++A GA IV + Sbjct: 140 DTIIEPTSGNTGIGLALAAAVRGYRCIIVMPEKMSSEKVDVLRALGAEIVRTPTNARFDS 199 Query: 132 DESRENVAKRVTEETEG-IMVHPNQEPAV-IAGQGTIALEVLNQVP-LVDALVVPVGGGG 188 ES VA R+ E ++ + + +A T A E+L Q +D LV VG GG Sbjct: 200 PESHVGVAWRLKNEIPNSHILDQYRNASNPLAHYDTTADEILQQCDGKLDMLVASVGTGG 259 Query: 189 MLAGIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGVKSSIGLNT 248 + GIA +K P ++ +P + P IG + Sbjct: 260 TITGIARKLKEKCPGCRIIGVDPEGSILAE---------PEELNQTEQTTYEVEGIGYDF 310 Query: 249 WPII--RDLVDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQTVSPEVK 306 P + R +VD F ++E +++ + LL +AG VA + E + Sbjct: 311 IPTVLDRTVVDKWFKSNDEEAFTFARMLIAQEGLLCGGSAGSTVAVAVK--AAQELQEGQ 368 Query: 307 NICIVLSGG 315 ++L Sbjct: 369 RCVVILPDS 377 >5OHX-A nrPDB Length = 504 Score = 263 bits (672), Expect = 8e-71, Method: Composition-based stats. Identities = 78/317 (24%), Positives = 136/317 (42%), Gaps = 24/317 (7%) Query: 11 DVEKAHINIRDSIHLTPVLTSSILNQLTG--RNLFFKCELFQKTGSFKIRGALNAVRSLV 68 D K +I +I TP++ + + + G ++ KCE GS K R A ++ Sbjct: 31 DYTKIMPDILTAIGQTPLIKLNNIPKSYGIKCEIYAKCEFLNPGGSVKDRIAYRMIQDAE 90 Query: 69 PDALERKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYC 128 L + ++ +SGN G L AA + G IV+P+ D K + A GA I+ Sbjct: 91 DKGLLKPGCTIIEPTSGNTGIGLAMAAAVRGYKCIIVMPEKMSDEKISTLYALGAKIIRT 150 Query: 129 E-----PSDESRENVAKRVTEETEG-IMVHPNQEPAV-IAGQGTIALEVLNQV-PLVDAL 180 S E+ +VA+++ +E I++ P +A A+E+ Q +D L Sbjct: 151 PTEASWHSPEAHISVAQKLQKEIPNSIILDQYTNPGNPLAHYDQTAIEIWKQCEGKIDYL 210 Query: 181 VVPVGGGGMLAGIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGV 240 V G GG ++GI +K L P++K+ A +P + L P+ + Sbjct: 211 VAGAGTGGTISGIGRKLKELSPNIKIIAVDPKGSI----------LDPSSDSQNEVGFYE 260 Query: 241 KSSIGLNTWPII--RDLVDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHF 298 IG + P + R+++D ++E A +++ + LL ++G + A L Sbjct: 261 VEGIGYDFIPTVLDRNVIDKWIKTEDNESLNAARMLIRQEGLLCGGSSGAALIAALKIAK 320 Query: 299 QTVSPEVKNICIVLSGG 315 PE K + I+L G Sbjct: 321 D--IPEEKRMVIILPDG 335 >1TDJ-A nrPDB Length = 514 Score = 262 bits (670), Expect = 1e-70, Method: Composition-based stats. Identities = 90/302 (29%), Positives = 157/302 (51%), Gaps = 6/302 (1%) Query: 19 IRDSIHLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVRSLVPDALERKPKA 78 + ++ +TP+ L+ + K E Q SFK+RGA + L E+K Sbjct: 25 VYEAAQVTPLQKMEKLSSRLDNVILVKREDRQPVHSFKLRGAYAMMAGLTE---EQKAHG 81 Query: 79 VVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYCEPSDESRENV 138 V+T S+GNH Q + +++ G+ A IV+P D K A++ +G ++ + + + Sbjct: 82 VITASAGNHAQGVAFSSARLGVKALIVMPTATADIKVDAVRGFGGEVLLHGANFDEAKAK 141 Query: 139 AKRVTEETEGIMVHPNQEPAVIAGQGTIALEVLNQVPLVDALVVPVGGGGMLAGIAITVK 198 A ++++ V P P VIAGQGT+ALE+L Q +D + VPVGGGG+ AG+A+ +K Sbjct: 142 AIELSQQQGFTWVPPFDHPMVIAGQGTLALELLQQDAHLDRVFVPVGGGGLAAGVAVLIK 201 Query: 199 ALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGVK-SSIGLNTWPIIRDLVD 257 L P +KV A E ++ + G + +L A+GV IG T+ + ++ +D Sbjct: 202 QLMPQIKVIAVEAEDSACLKAALDAGHPV-DLPRVGLFAEGVAVKRIGDETFRLCQEYLD 260 Query: 258 DIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQTVSPEVKNICIVLSGGNV 317 DI TV D I A + ++E ++ + EP+ + +A + ++ + + + +LSG NV Sbjct: 261 DIITVDSDAICAAMKDLFEDVRAVAEPSGALALAG-MKKYIALHNIRGERLAHILSGANV 319 Query: 318 DL 319 + Sbjct: 320 NF 321 >3IAU-A nrPDB Length = 366 Score = 260 bits (664), Expect = 7e-70, Method: Composition-based stats. Identities = 92/303 (30%), Positives = 157/303 (51%), Gaps = 6/303 (1%) Query: 19 IRDSIHLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVRSLVPDALERKPKA 78 + D +P+ + L+ G N + K E Q+ SFK+RGA N + +L + L++ Sbjct: 54 VYDVAIESPLELAEKLSDRLGVNFYIKREDKQRVFSFKLRGAYNMMSNLSREELDK---G 110 Query: 79 VVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYCEPSDESRENV 138 V+T S+GNH Q + A + A IV+P T P K A++A G +V + + + Sbjct: 111 VITASAGNHAQGVALAGQRLNCVAKIVMPTTTPQIKIDAVRALGGDVVLYGKTFDEAQTH 170 Query: 139 AKRVTEETEGIMVHPNQEPAVIAGQGTIALEVLNQVPLVDALVVPVGGGGMLAGIAITVK 198 A ++E+ + P +P VI GQGTI E+ Q+ + A+ +PVGGGG++AG+A K Sbjct: 171 ALELSEKDGLKYIPPFDDPGVIKGQGTIGTEINRQLKDIHAVFIPVGGGGLIAGVATFFK 230 Query: 199 ALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGVKSSI-GLNTWPIIRDLVD 257 + P+ K+ EP A S +G + L +T ADGV ++ G T+ ++L+D Sbjct: 231 QIAPNTKIIGVEPYGAASMTLSLHEGHRV-KLSNVDTFADGVAVALVGEYTFAKCQELID 289 Query: 258 DIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQTVSPEVKNICIVLSGGNV 317 + V D I A + V++ + ++E T+G A + + + + +NI + SG N+ Sbjct: 290 GMVLVANDGISAAIKDVYDEGRNILE-TSGAVAIAGAAAYCEFYKIKNENIVAIASGANM 348 Query: 318 DLT 320 D + Sbjct: 349 DFS 351 >2GN1-A nrPDB Length = 342 Score = 254 bits (649), Expect = 4e-68, Method: Composition-based stats. Identities = 113/326 (34%), Positives = 175/326 (53%), Gaps = 8/326 (2%) Query: 7 ISFADVEKAHINIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVRS 66 ++ D+ +A + I+ T + S+ ++ +F K E Q+TGSFKIRGA N + S Sbjct: 22 VAIEDILEAKKRLAGKIYKTGMPRSNYFSERCKGEIFLKFENMQRTGSFKIRGAFNKLSS 81 Query: 67 LVPDALERKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIV 126 L K K VV S+GNH Q ++ + + GI +V+P+ AP K A Y A +V Sbjct: 82 LTE---AEKRKGVVACSAGNHAQGVSLSCAMLGIDGKVVMPKGAPKSKVAATCDYSAEVV 138 Query: 127 YCEPSDESRENVAKRVTEETEGIMVHPNQEPAVIAGQGTIALEVLNQVPLVDALVVPVGG 186 + + E I + P +P VIAGQGTI LE++ + VD ++VP+GG Sbjct: 139 LHGDNFNDTIAKVSEIVETEGRIFIPPYDDPKVIAGQGTIGLEIMEDLYDVDNVIVPIGG 198 Query: 187 GGMLAGIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGV-KSSIG 245 GG++AGIAI +K++ P++KV + N S G++ + T+ADG S G Sbjct: 199 GGLIAGIAIAIKSINPTIKVIGVQAENVHGMAASYYTGEITTH-RTTGTLADGCDVSRPG 257 Query: 246 LNTWPIIRDLVDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQTVSPEV 305 T+ I+R+LVDDI V+EDEI+ + + +R K++ E + AA+LS + Sbjct: 258 NLTYEIVRELVDDIVLVSEDEIRNSMIALIQRNKVITEGAGALACAALLSGKLDSHIQNR 317 Query: 306 KNICIVLSGGNVDLT--SSITWVKQA 329 K + I+ SGGN+DL+ S IT + A Sbjct: 318 KTVSII-SGGNIDLSRVSQITGLVDA 342 >1VE5-A nrPDB Length = 311 Score = 250 bits (638), Expect = 7e-67, Method: Composition-based stats. Identities = 132/318 (41%), Positives = 191/318 (60%), Gaps = 15/318 (4%) Query: 8 SFADVEKAHINIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVRSL 67 S D+ A I H TP+LTS +L+ L G+ L K E QKTGSFK RGAL+ +L Sbjct: 3 SLQDLYAAFRRIAPYTHRTPLLTSRLLDGLLGKRLLLKAEHLQKTGSFKARGALSKALAL 62 Query: 68 VPDALERKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVY 127 PK ++ SSGNH Q + YAA++ G+ A +V+P+ A KK +AYGA +V Sbjct: 63 E------NPKGLLAVSSGNHAQGVAYAAQVLGVKALVVMPEDASPYKKACARAYGAEVVD 116 Query: 128 CEPSDESRENVAKRVTEETEGIMVHPNQEPAVIAGQGTIALEVLNQVPLV----DALVVP 183 + ++RE VA+ + EET ++HP +P VIAGQGT LE+L Q + A++ P Sbjct: 117 RGVTAKNREEVARALQEETGYALIHPFDDPLVIAGQGTAGLELLAQAGRMGVFPGAVLAP 176 Query: 184 VGGGGMLAGIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGVKS- 242 VGGGG+LAG+A VKAL P+ V EP ADD +S G+++ PP T ADGV++ Sbjct: 177 VGGGGLLAGLATAVKALSPTTLVLGVEPEAADDAKRSLEAGRILRLEAPPRTRADGVRTL 236 Query: 243 SIGLNTWPIIRDLVDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQTVS 302 S+G T+PI+R+ VD I TV+E+ + A +L++ R K ++EPT + +AAVL + Sbjct: 237 SLGERTFPILRERVDGILTVSEEALLEAERLLFTRTKQVVEPTGALPLAAVLEHGARL-- 294 Query: 303 PEVKNICIVLSGGNVDLT 320 + + ++LSGGN D + Sbjct: 295 --PQTLALLLSGGNRDFS 310 >3FCA-A nrPDB Length = 291 Score = 246 bits (629), Expect = 8e-66, Method: Composition-based stats. Identities = 71/309 (22%), Positives = 129/309 (41%), Gaps = 28/309 (9%) Query: 19 IRDSIHLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVRSLVPDALERKPKA 78 + I TP++ ++ + K E GS K R AL + L + Sbjct: 2 MERLIGSTPIVRLDSID----SRIALKLEKNNPGGSVKDRPALFMILDAEKRGLLKNG-- 55 Query: 79 VVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYCEP--SDESRE 136 +V +SGN G A+ G + +P+T ++ ++ GA +V + Sbjct: 56 IVEPTSGNMGIAIAMIGAKRGHRVILTMPETMSVERRKVLKMLGAELVLTPGELGMKGAV 115 Query: 137 NVAKRVTEETEGIMVHPNQEPA-VIAGQGTIALEVLNQVP-LVDALVVPVGGGGMLAGIA 194 A ++ ET M++ + P V + Q T E+L Q+ +DA V VG GG ++G+ Sbjct: 116 EKALEISRETGAHMLNQFENPYNVYSHQFTTGPEILKQMDYQIDAFVAGVGTGGTISGVG 175 Query: 195 ITVKALKPS-VKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGVKSSIGLNTWPII- 252 +K + VK+ A EP+ K ++ P + G IG P I Sbjct: 176 RVLKGFFGNGVKIVAVEPA----------KSPVLSGGQPGKHAIQG----IGAGFVPKIL 221 Query: 253 -RDLVDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQTVSPEVKNICIV 311 R ++D++ TV ++E + + ++ LL+ ++G VAA L Q + P+ + + + Sbjct: 222 DRSVIDEVITVEDEEAYEMARYLAKKEGLLVGISSGANVAAALK-VAQKLGPDARVVTVA 280 Query: 312 LSGGNVDLT 320 L+ Sbjct: 281 PDHAERYLS 289 >5C3U-A nrPDB Length = 366 Score = 246 bits (629), Expect = 8e-66, Method: Composition-based stats. Identities = 75/334 (22%), Positives = 149/334 (44%), Gaps = 21/334 (6%) Query: 9 FADVEKAHINIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVRSLV 68 F D++ H+ TP+L + L + N+F K E Q +GS K+RG + + Sbjct: 12 FDDLQSLHV-------ATPLLHAPNLTKELECNVFLKMENIQPSGSVKMRG----IGAFC 60 Query: 69 PDALERKPKAV--VTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIV 126 A++ + + V S N A++Y A+ G+ A IVVP+ + +I+ G+ ++ Sbjct: 61 YQAVQTRGTNIQFVCGSGPNTVLAVSYCARQLGVEAIIVVPKATNERICQSIRTDGSHLI 120 Query: 127 YCEPSDESRENVAKRVTEETEGIMVHPNQEPAVIAGQGTIALEVLNQV--PLVDALVVPV 184 + + E A+++ I V + + G TI E+ Q+ A++ PV Sbjct: 121 LYGENWTAAEVHARKLVRRNG-IYVPSSDHALIWQGHSTIVQELKTQLNDNPPAAIICPV 179 Query: 185 GGGGMLAGIAITVKA-LKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGVKSS 243 GGGG+L G+ + ++ V V A E ++ S + G+L+ + + Sbjct: 180 GGGGLLNGVIMGLQEADWKDVPVIAVETHGSNAFQASVVAGELVIMEKNNTIATSLISKA 239 Query: 244 IGLNTWPIIRDLVDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQTVSP 303 + + + + F V++ A +L E K+L+E +AG ++ + + + P Sbjct: 240 VSSKSLELSLNHPVVPFAVSDAMAADAVRLFAEDFKMLVEASAGAALSLCYTHLIRDILP 299 Query: 304 E---VKNICIVLSGG-NVDLTSSITWVKQAERPA 333 K++ ++++GG ++ L + K+ PA Sbjct: 300 SLSPAKDVVVLVTGGSDISLAHLDEYRKKYMHPA 333 >2EFY-A nrPDB Length = 304 Score = 246 bits (628), Expect = 9e-66, Method: Composition-based stats. Identities = 71/313 (22%), Positives = 125/313 (39%), Gaps = 19/313 (6%) Query: 17 INIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVRSLVPDALERKP 76 + + +I TPV+ + + + ++ K E GS K R A ++ + R Sbjct: 1 MRVEGAIGKTPVVRLAKVVEPDMAEVWVKLEGLNPGGSIKDRPAWYMIKDAEERGILRPG 60 Query: 77 KA--VVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYCEPSDE- 133 +V +SGN G L A G + +P + +K ++A+GA +V +P Sbjct: 61 SGQVIVEPTSGNTGIGLAMIAASRGYRLILTMPAQMSEERKRVLKAFGAELVLTDPERRM 120 Query: 134 -SRENVAKRVTEETEGIMVHPNQEPAVI-AGQGTIALEVLNQV-PLVDALVVPVGGGGML 190 + A R+ EE M + PA + A T E+ + +DA V G GG + Sbjct: 121 LAAREEALRLKEELGAFMPDQFKNPANVRAHYETTGPELYEALEGRIDAFVYGSGTGGTI 180 Query: 191 AGIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGVKSSIGLNTWP 250 G+ +K P VKV A EP+ ++ K+ + P G Sbjct: 181 TGVGRYLKERIPHVKVIAVEPARSNVLSGGKMGQHGFQGMGP------------GFIPEN 228 Query: 251 IIRDLVDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQTVSPEVKNICI 310 + L+D + V E++ + + L + ++G V A L Q + + P + CI Sbjct: 229 LDLSLLDGVIQVWEEDAFPLARRLAREEGLFLGMSSGGIVWAAL-QVARELGPGKRVACI 287 Query: 311 VLSGGNVDLTSSI 323 GG L++ + Sbjct: 288 SPDGGWKYLSTPL 300 >2JC3-A nrPDB Length = 303 Score = 246 bits (628), Expect = 1e-65, Method: Composition-based stats. Identities = 60/307 (19%), Positives = 119/307 (38%), Gaps = 25/307 (8%) Query: 19 IRDSIHLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVRSLVPDALERKPKA 78 + +I TP++ + G ++ K E GS K R AL+ + + Sbjct: 4 LEQTIGNTPLVKLQRIGPDNGSEIWVKLEGNNPAGSVKDRAALSMIVEAEKRGEIKPGDV 63 Query: 79 VVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYC--EPSDESRE 136 ++ +SGN G AL A L+G +++P ++ A++AYGA ++ E E Sbjct: 64 LIEATSGNTGIALAMIAALKGYRMKLLMPDNMSQERRAAMRAYGAELILVTKEQGMEGAR 123 Query: 137 NVAKRVTEETEGIMVHPNQEPAV-IAGQGTIALEVLNQV-PLVDALVVPVGGGGMLAGIA 194 ++A ++E EG ++ P A T E+ Q + V +G G + G++ Sbjct: 124 DLALAMSERGEGKLLDQFNNPDNPYAHYTTTGPEIWRQTSGRITHFVSSMGTTGTITGVS 183 Query: 195 ITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGVKSSIGLNTWPIIRD 254 ++ + V + +P S + P Y P Sbjct: 184 RFLREQEKPVTIVGLQPEEG----SSIPGIRRWPAEYMPGIFNA---------------S 224 Query: 255 LVDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQTVSPEVKNICIVLSG 314 LVD++ + +++ + + + R + ++G VA L +P + I+ Sbjct: 225 LVDEVLDIHQNDAENTMRELAVREGIFCGVSSGGAVAGAL--RVARATPGAIVVAIICDR 282 Query: 315 GNVDLTS 321 G+ L++ Sbjct: 283 GDRYLST 289 >2BHS-A nrPDB Length = 303 Score = 245 bits (626), Expect = 2e-65, Method: Composition-based stats. Identities = 59/307 (19%), Positives = 116/307 (37%), Gaps = 25/307 (8%) Query: 19 IRDSIHLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVRSLVPDALERKPKA 78 + +I TP++ + G ++ K E GS K R AL+ + + Sbjct: 4 LEQTIGNTPLVKLQRMGPDNGSEVWLKLEGNNPAGSVKDRAALSMIVEAEKRGEIKPGDV 63 Query: 79 VVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYC--EPSDESRE 136 ++ +SGN G AL A L+G +++P ++ A++AYGA ++ E E Sbjct: 64 LIEATSGNTGIALAMIAALKGYRMKLLMPDNMSQERRAAMRAYGAELILVTKEQGMEGAR 123 Query: 137 NVAKRVTEETEGIMVHPNQEPAV-IAGQGTIALEVLNQV-PLVDALVVPVGGGGMLAGIA 194 ++A + EG ++ P A T E+ Q + V +G G + G++ Sbjct: 124 DLALEMANRGEGKLLDQFNNPDNPYAHYTTTGPEIWQQTGGRITHFVSSMGTTGTITGVS 183 Query: 195 ITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGVKSSIGLNTWPIIRD 254 ++ V + +P S + P Y P Sbjct: 184 RFMREQSKPVTIVGLQPEEG----SSIPGIRRWPTEYLPGIFNA---------------S 224 Query: 255 LVDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQTVSPEVKNICIVLSG 314 LVD++ + + + + + + R + ++G VA L +P+ + I+ Sbjct: 225 LVDEVLDIHQRDAENTMRELAVREGIFCGVSSGGAVAGAL--RVAKANPDAVVVAIICDR 282 Query: 315 GNVDLTS 321 G+ L++ Sbjct: 283 GDRYLST 289 >6AHI-A nrPDB Length = 314 Score = 238 bits (606), Expect = 3e-63, Method: Composition-based stats. Identities = 62/318 (19%), Positives = 125/318 (39%), Gaps = 25/318 (7%) Query: 19 IRDSIHLTPVLTSSILNQLTGRN--LFFKCELFQKTGSFKIRGALNAVRSLVPDALERKP 76 ++D+I TPV + + N ++ K E GS K R + Sbjct: 7 MQDAIGRTPVFKFTNKDYPIPLNSAIYAKLEHLNPGGSVKDRLGQYLIGEGFKTGKITSK 66 Query: 77 KAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYCEPSDE--S 134 ++ ++GN G AL A + VVP+ K+ ++A GA ++ S+ Sbjct: 67 TTIIEPTAGNTGIALALVAIKHHLKTIFVVPEKFSTEKQQIMRALGALVINTPTSEGISG 126 Query: 135 RENVAKRVTEETEGIMVH-PNQEPAVI-AGQGTIALEVLNQVP-LVDALVVPVGGGGMLA 191 +K + E + + P A T+A E++ ++ + + V +G GG A Sbjct: 127 AIKKSKELAESIPDSYLPLQFENPDNPAAYYHTLAPEIVQELGTNLTSFVAGIGSGGTFA 186 Query: 192 GIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGVKSSIGLNTWPI 251 G A +K P++++ EP + ++ P +G IG+ P Sbjct: 187 GTARYLKERIPAIRLIGVEPEGS-----------ILNGGEPGPHEIEG----IGVEFIPP 231 Query: 252 IRDL--VDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQTVSPEVKNIC 309 + +D T++++E T+ + ++ LL+ ++G A L + Q + + + Sbjct: 232 FFENLDIDGFETISDEEGFSYTRKLAKKNGLLVGSSSGAAFVAALKE-AQRLPEGSQVLT 290 Query: 310 IVLSGGNVDLTSSITWVK 327 I + L+ I ++ Sbjct: 291 IFPDVADRYLSKGIYLLQ 308 >6C2H-A nrPDB Length = 375 Score = 238 bits (606), Expect = 4e-63, Method: Composition-based stats. Identities = 64/313 (20%), Positives = 121/313 (38%), Gaps = 28/313 (8%) Query: 17 INIRDSIHLTPVLTSSILNQLTGR--NLFFKCELFQKTGSFKIRGALNAVRSLVPDALER 74 N+ D + TP++ L + G ++ K EL+ GS K R A + V Sbjct: 34 HNVIDLVGNTPLIALKKLPKALGIKPQIYAKLELYNPGGSIKDRIAKSMVEEAEASGRIH 93 Query: 75 KPK-AVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYCEP--- 130 + ++ +SGN G L ++G I +P+ + K ++A GA I+ Sbjct: 94 PSRSTLIEPTSGNTGIGLALIGAIKGYRTIITLPEKMSNEKVSVLKALGAEIIRTPTAAA 153 Query: 131 --SDESRENVAKRVTEETEG-IMVHPNQEPAVI-AGQGTIALEVLNQVPLVD------AL 180 S ES VAK++ +E G +++ A E+ Q+ ++ A+ Sbjct: 154 WDSPESHIGVAKKLEKEIPGAVILDQYNNMMNPEAHYFGTGREIQRQLEDLNLFDNLRAV 213 Query: 181 VVPVGGGGMLAGIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGV 240 V G GG ++GI+ +K +++ A+P + P I D Sbjct: 214 VAGAGTGGTISGISKYLKEQNDKIQIVGADPFGSILAQ---------PENLNKTDITDYK 264 Query: 241 KSSIGLNTWPII--RDLVDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHF 298 IG + P + R L+D + + + + +L+ ++G AV+ + Sbjct: 265 VEGIGYDFVPQVLDRKLIDVWYKTDDKPSFKYARQLISNEGVLVGGSSGSAFTAVVK-YC 323 Query: 299 QTVSPEVKNICIV 311 + ++ IV Sbjct: 324 EDHPELTEDDVIV 336 >3PC3-A nrPDB Length = 527 Score = 238 bits (606), Expect = 4e-63, Method: Composition-based stats. Identities = 68/314 (21%), Positives = 127/314 (40%), Gaps = 22/314 (7%) Query: 13 EKAHINIRDSIHLTPVLTSSIL--NQLTGRNLFFKCELFQKTGSFKIRGALNAVRSLVPD 70 ++ NI + I TP++ + + + ++ KCE GS K R V+ Sbjct: 48 QQITPNILEVIGCTPLVKLNNIPASDGIECEMYAKCEFLNPGGSVKDRIGYRMVQDAEEQ 107 Query: 71 ALERKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYCEP 130 L + ++ +SGN G L A ++G IV+P+ + K A++ GA I+ Sbjct: 108 GLLKPGYTIIEPTSGNTGIGLAMACAVKGYKCIIVMPEKMSNEKVSALRTLGAKIIRTPT 167 Query: 131 -----SDESRENVAKRVTEETEG-IMVHPNQEPAV-IAGQGTIALEVLNQVP-LVDALVV 182 S E VA+++ ET I++ + +A A E+L Q+ VD +VV Sbjct: 168 EAAYDSPEGLIYVAQQLQRETPNSIVLDQYRNAGNPLAHYDGTAAEILWQLDNKVDMIVV 227 Query: 183 PVGGGGMLAGIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGVKS 242 G G ++GI +K PS ++ +P + P + Sbjct: 228 SAGTAGTISGIGRKIKEQVPSCQIVGVDPYGSILAR---------PAELNKTDVQFYEVE 278 Query: 243 SIGLNTWPIIRD--LVDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQT 300 IG + P + D +VD + + + ++ + LL ++G + A L +H + Sbjct: 279 GIGYDFPPTVFDDTVVDVWTKIGDSDCFPMSRRLNAEEGLLCGGSSGGAMHAAL-EHARK 337 Query: 301 VSPEVKNICIVLSG 314 + + + I+ G Sbjct: 338 LKKGQRCVVILPDG 351 >2Q3D-A nrPDB Length = 313 Score = 232 bits (592), Expect = 2e-61, Method: Composition-based stats. Identities = 71/317 (22%), Positives = 125/317 (39%), Gaps = 21/317 (6%) Query: 14 KAHINIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVRSLVPDALE 73 +I I TP++ + ++ K E F S K R + +++ L Sbjct: 5 SIAEDITQLIGRTPLVRLRRVTDGAVADIVAKLEFFNPANSVKDRIGVAMLQAAEQAGLI 64 Query: 74 RKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYCEPSDE 133 + ++ +SGN G AL G + +P+T +++ ++AYGA ++ +D Sbjct: 65 KPDTIILEPTSGNTGIALAMVCAARGYRCVLTMPETMSLERRMLLRAYGAELILTPGADG 124 Query: 134 SRENVAK--RVTEETEGIMVH-PNQEPAVIA-GQGTIALEVLNQVP-LVDALVVPVGGGG 188 +AK + + + V + PA A + T A EV VD +V VG GG Sbjct: 125 MSGAIAKAEELAKTDQRYFVPQQFENPANPAIHRVTTAEEVWRDTDGKVDIVVAGVGTGG 184 Query: 189 MLAGIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGVKSSIGLNT 248 + G+A +K KPS + A EP A KG IG Sbjct: 185 TITGVAQVIKERKPSARFVAVEP-AASPVLSGGQKGPHP-------------IQGIGAGF 230 Query: 249 WPII--RDLVDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQTVSPEVK 306 P + +DLVD+I TV ++ + + LL+ ++G A L + + Sbjct: 231 VPPVLDQDLVDEIITVGNEDALNVARRLAREEGLLVGISSGAATVAALQVARRPENAGKL 290 Query: 307 NICIVLSGGNVDLTSSI 323 + ++ G L++ + Sbjct: 291 IVVVLPDFGERYLSTPL 307 >4OFX-A nrPDB Length = 319 Score = 231 bits (589), Expect = 3e-61, Method: Composition-based stats. Identities = 70/325 (21%), Positives = 129/325 (39%), Gaps = 31/325 (9%) Query: 17 INIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVRSLVPDALERKP 76 NI I TPV+ + Q L+ KCE GS K R + S + Sbjct: 7 DNILQVIGKTPVVRLHRIGQSLPCELYGKCEFLNPGGSVKDRIGAAMIESAEKQGKIKPG 66 Query: 77 KAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYCEPS----- 131 ++ +SGN G + A ++G I +P+ K++ ++A GA+I Sbjct: 67 DTLIEPTSGNTGIGIALAGAVKGYRVIITMPEKMSHEKQVVLEALGATIYRTPTEAAYDD 126 Query: 132 DESRENVAKRVTEETEGIMVHPN----QEPAVIAGQGTIALEVLNQVPL-VDALVVPVGG 186 ES ++AKR+ +E + + P + T E+L+ + + +V+ VG Sbjct: 127 PESHISLAKRLNQEIPNSYILDQYSNAENPDI--HYQTTGQEILDDMGENLSMVVMGVGT 184 Query: 187 GGMLAGIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGVKSSIGL 246 GG + G+A +K + PS+++ +P + L + I + IG Sbjct: 185 GGTIIGVAKKLKEVNPSIQIIGVDPIGS--------------ILGGGDEIKPYLVEGIGY 230 Query: 247 NTWPIIRD--LVDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQTVSPE 304 + P + D L+D+ + + + + + LL+ ++G V A Q Q + Sbjct: 231 DFIPEVLDNNLIDEYIKINDKDSFLMARRLIREEGLLVGGSSGSAVWAA-CQAAQRLKEG 289 Query: 305 VKNICIVLSGGNVDLT--SSITWVK 327 + + I+ LT W+K Sbjct: 290 ERCLVILPDAIRNYLTKFVDDAWMK 314 >5JJC-A nrPDB Length = 342 Score = 230 bits (587), Expect = 6e-61, Method: Composition-based stats. Identities = 73/318 (22%), Positives = 127/318 (39%), Gaps = 21/318 (6%) Query: 16 HINIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVRSLVPDALERK 75 ++ D+I TP++ S ++LTG +++ K E S K R AL +R L R Sbjct: 2 FNSVLDTIGNTPLIRLSKASELTGCDIYGKAEFLNPGQSVKDRAALYIIRDAEKRGLLRP 61 Query: 76 PKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYCEP----S 131 +V ++GN G LT AK G IV+P+TA KK A++ GA ++ + Sbjct: 62 GGVIVEGTAGNTGIGLTMVAKALGYRTAIVIPETASQEKKDALRLLGAELIEVPAAPYRN 121 Query: 132 DESRENVAKRVTEE------TEGIMVHPNQEPAVIAGQ-GTIALEVLNQV-PLVDALVVP 183 + ++ R+ E+ I + T A E+ +D V Sbjct: 122 PNNAVRLSGRLAEQLAKTEPNGAIWANQFDNTVNRQAHIETTAQEIWRDTSDQIDGFVAA 181 Query: 184 VGGGGMLAGIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYP-PETIADGVKS 242 VG GG LAG AI +K ++K+ A+P A + G+L E I G + Sbjct: 182 VGSGGTLAGTAIGLKERNHNIKIALADPHGA-ALHAFYTTGELKAEGDSITEGIGQGRIT 240 Query: 243 SIGLNTWPIIRDLVDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQTVS 302 + P + + + E + E L + ++G+ +A + + + Sbjct: 241 ANLEGFTPDFS------YQIPDAEALDILFALVEEEGLCLGGSSGINIAGAIR-LAKDLG 293 Query: 303 PEVKNICIVLSGGNVDLT 320 P + ++ GN + Sbjct: 294 PGHTIVTVLCDYGNRYQS 311 >2PQM-A nrPDB Length = 343 Score = 229 bits (583), Expect = 1e-60, Method: Composition-based stats. Identities = 72/327 (22%), Positives = 131/327 (40%), Gaps = 25/327 (7%) Query: 13 EKAHINIRDSIHLTPVLTSSILNQ----LTGRNLFFKCELFQKTGSFKIRGALNAVRSLV 68 ++ + NI ++I TP++ + + G + K E F S K R N V + Sbjct: 11 KRIYHNILETIGGTPLVELHGVTEHPRIKKGTRILVKLEYFNPMSSVKDRVGFNIVYQAI 70 Query: 69 PDALERKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYC 128 D + ++ +SGN G AL A + G I +P T +++ ++A+GA ++ Sbjct: 71 KDGRLKPGMEIIESTSGNTGIALCQAGAVFGYRVNIAMPSTMSVERQMIMKAFGAELILT 130 Query: 129 EPSDESRENV--AKRVTEETEGIMV--HPNQEPAVIAGQGTIALEVLNQVP-LVDALVVP 183 E + ++ +E G + P A A E+ VD +V Sbjct: 131 EGKKGMPGAIEEVNKMIKENPGKYFVANQFGNPDNTAAHHYTANEIWEDTDGEVDIVVSA 190 Query: 184 VGGGGMLAGIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGVKSS 243 VG G + G+A +K K +K+ A EP + + K KG P I Sbjct: 191 VGTSGTVIGVAEKLKEKKKGIKIIAVEPEES-AVLEGKAKG--------PHGI-----QG 236 Query: 244 IGLNTWPII--RDLVDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQTV 301 IG P I ++ VD+I + + + V + ++ ++G + A L + + Sbjct: 237 IGAGFIPDIYKKEFVDEIIPIKTQDAWKMARAVVKYDGIMCGMSSGAAILAGLKEAEKPE 296 Query: 302 SPEVKNICIVLSGGNVDLTSSITWVKQ 328 + + IV S G L++ + +K Sbjct: 297 NEGKTIVIIVPSCGERYLSTDLYKIKD 323 >5XW3-A nrPDB Length = 315 Score = 227 bits (578), Expect = 7e-60, Method: Composition-based stats. Identities = 60/316 (18%), Positives = 113/316 (35%), Gaps = 23/316 (7%) Query: 15 AHINIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVRSLVPDALER 74 + + + I TP++ + + G LF K E + GS K R + + L Sbjct: 3 VYRGVHELIGHTPIVEITRFSLPEGVRLFAKLEFYNPGGSVKDRLGRELIEDALEKGLVT 62 Query: 75 KPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVY--CEPSD 132 + ++ ++GN G L AA + + VP+ K+ ++A GA++V+ E Sbjct: 63 EGGTIIEPTAGNTGIGLALAALQHDLRVIVCVPEKFSIEKQELMKALGATVVHTPTEQGM 122 Query: 133 ESRENVAKRVTEETEGIMVH-PNQEPAVIAGQ-GTIALEVLNQV-PLVDALVVPVGGGGM 189 AK + E A T+ E+ + + ++ V G GG Sbjct: 123 TGAIAKAKELVNEIPNSYSPSQFANEANPRAYFKTLGPELWSALNGEINIFVAGAGTGGT 182 Query: 190 LAGIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGVKSSIGLNTW 249 G A +K +K EP + ++ +G IGL Sbjct: 183 FMGTASYLKEKNIDIKTVIVEPEGS-----------ILNGGKAGSHETEG----IGLEFI 227 Query: 250 PIIRD--LVDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQTVSPEVKN 307 P D+I T+++ + + ++ LL+ ++G A L + + +P Sbjct: 228 PPFLKTSYFDEIHTISDRNAFLRVKELAQKEGLLVGSSSGAAFHASLLE-AEKAAPGTNI 286 Query: 308 ICIVLSGGNVDLTSSI 323 + I L+ I Sbjct: 287 VTIFPDSSERYLSKDI 302 >6NMX-A nrPDB Length = 354 Score = 225 bits (573), Expect = 2e-59, Method: Composition-based stats. Identities = 83/331 (25%), Positives = 139/331 (41%), Gaps = 31/331 (9%) Query: 24 HLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVRSLVPDALERKPKAVVTHS 83 TP++ L++ G L K E TGSFK RG + AV A E ++ S Sbjct: 29 GNTPLIHLPKLSEQLGIELHVKTEGVNPTGSFKDRGMVMAVA----KAKEEGNDTIMCAS 84 Query: 84 SGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQ-AYGASIVYCEPSDESRENVAKRV 142 +GN A A + +++P KLA YGA I+ + + + + + + Sbjct: 85 TGNTSAAAAAYAARANMKCIVIIPNGKIAFGKLAQAVMYGAEIIAIDGNFDDALKIVRSI 144 Query: 143 TEETEGIMVHPNQEPAVIAGQGTIALEVLNQVPLV-DALVVPVGGGGMLAGIAITVKALK 201 E++ +V+ + P + GQ T A EV Q+ D L +PVG G ++ K Sbjct: 145 CEKSPIALVN-SVNPYRLEGQKTAAFEVCEQLGEAPDVLAIPVGNAGNISAYWKGFKEYH 203 Query: 202 -------PSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGVKSSIGLNTWPIIRD 254 P ++ + AE S A ++ +++ N PETIA ++ +W Sbjct: 204 EKNGTSLPKMRGFEAEGSAA------IVRNEVIEN---PETIATAIRIG-NPASWDKAVK 253 Query: 255 LVDD----IFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQTVSPEVKNICI 310 ++ I VT+DEI A QL+ + EP + +A VL Q P+ + Sbjct: 254 AAEESNGKIDEVTDDEILHAYQLIAREEGVFAEPGSCASIAGVLKQVKSGEIPKGSKVVA 313 Query: 311 VLSGGNV---DLTSSITWVKQAERPASYQSV 338 VL+G + + I+ +K P + S+ Sbjct: 314 VLTGNGLKDPNTAVDISEIKPVTLPTNEDSI 344 >1PWH-A nrPDB Length = 327 Score = 224 bits (572), Expect = 3e-59, Method: Composition-based stats. Identities = 82/313 (26%), Positives = 146/313 (46%), Gaps = 17/313 (5%) Query: 20 RDSIH-LTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVRSLVPDALERKPKA 78 ++S+H TP+ S L+++ G ++F K + Q +GSFKIRG + L ++ K Sbjct: 4 QESLHVKTPLRDSMALSKVAGTSVFLKMDSSQPSGSFKIRG----IGHLCKMKAKQGCKH 59 Query: 79 VVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYCEPSDESRENV 138 V S+GN G A YAA+ G+PA IVVP T P ++ GA++ + + Sbjct: 60 FVCSSAGNAGMATAYAARRLGLPATIVVPSTTPALTIERLKNEGATVEVVGEMLDEAIQL 119 Query: 139 AKRVTEETE-GIMVHPNQEPAVIAGQGTIALEVLNQVP-LVDALVVPVGGGGMLAGIAIT 196 AK + + + + P +P + G ++ E+ + A+V+ VGGGG+L G+ Sbjct: 120 AKALEKNNPGWVYISPFDDPLIWEGHTSLVKELKETLSAKPGAIVLSVGGGGLLCGVVQG 179 Query: 197 VKAL-KPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGVKS-SIGLNTWPIIRD 254 ++ + V + A E A + + +GKL+ L ++A + ++G T + + Sbjct: 180 LREVGWEDVPIIAMETFGAHSFHAAVKEGKLVT-LPKITSVAKALGVNTVGAQTLKLFYE 238 Query: 255 LVDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLS-------QHFQTVSPEVKN 307 +++ E A + + K+L+EP G +AAV S + +P Sbjct: 239 HPIFSEVISDQEAVTAIEKFVDDEKILVEPACGAALAAVYSGVVCRLQAEARLQTPLASL 298 Query: 308 ICIVLSGGNVDLT 320 + IV G N+ L Sbjct: 299 VVIVCGGSNISLA 311 >4I1Y-A nrPDB Length = 314 Score = 224 bits (571), Expect = 4e-59, Method: Composition-based stats. Identities = 71/314 (22%), Positives = 121/314 (38%), Gaps = 21/314 (6%) Query: 17 INIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVRSLVPDALERKP 76 NI I TP++ + ++ K E F GS K R + + + L + Sbjct: 9 ENIAQLIGGTPLVRLRRVTDGAAADVVAKLESFNPAGSIKDRIGVAMIDAAEKAGLIKPD 68 Query: 77 KAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYCEPSDESRE 136 ++ +SGN G AL + G + +P T +++ ++AYGA +V ++ Sbjct: 69 TIILEPTSGNTGIALAMVSAARGYKCVLTMPDTMSIERRMLLRAYGAELVLTPGAEGMAG 128 Query: 137 NVAK--RVTEETEGIMVH-PNQEPAVIAGQG-TIALEVLNQVP-LVDALVVPVGGGGMLA 191 +AK + + + + + PA A T A EV VD V VG GG + Sbjct: 129 AIAKAEELAKTDDRYFIPQQFENPANPAVHAVTTAEEVWRDTDGKVDIFVSGVGTGGTIT 188 Query: 192 GIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGVKSSIGLNTWPI 251 G+A +K +PS + A EP A KG IG P Sbjct: 189 GVAQVIKQRRPSAQFVAVEP-AASPVLSGGQKGPHP-------------IQGIGAGFVPP 234 Query: 252 IRD--LVDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQTVSPEVKNIC 309 + D LVD++ TV D+ + + LL ++G V A + + + Sbjct: 235 VLDLALVDEVITVGNDDALELARRMATEEGLLFGISSGAAVWAARELAHRPENAGKLIVV 294 Query: 310 IVLSGGNVDLTSSI 323 ++ G L++ + Sbjct: 295 VLPDFGERYLSTVL 308 >3VBE-A nrPDB Length = 344 Score = 222 bits (565), Expect = 2e-58, Method: Composition-based stats. Identities = 63/315 (20%), Positives = 130/315 (41%), Gaps = 18/315 (5%) Query: 15 AHINIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVRSLVPDALER 74 ++ I TP++ + + + G + K E+ Q T S K R A + L Sbjct: 25 IKKHVSQLIGRTPLVYLNKVTEGCGAYVAVKQEMMQPTASIKDRPAYAMITDAEEKNLIT 84 Query: 75 KPKA-VVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYCEPSDE 133 K ++ +SGN G ++ + A ++G + +P +++ ++A+GA ++ +P+ Sbjct: 85 PGKTTLIEPTSGNMGISMAFMAAMKGYKMVLTMPSYTSLERRVTMRAFGAELILTDPAKG 144 Query: 134 SRENV--AKRVTEETE-GIMVHPNQEPAVIAGQ-GTIALEVLNQV-PLVDALVVPVGGGG 188 V A + E T M+ PA T E+ VD V+ +G GG Sbjct: 145 MGGTVKKAYELLENTPNAHMLQQFSNPANTQVHFETTGPEIWEDTNGQVDIFVMGIGSGG 204 Query: 189 MLAGIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGVKSSIGLNT 248 ++G+ +K+ P+VK+Y EPS ++ K P I + +G Sbjct: 205 TVSGVGQYLKSKNPNVKIYGVEPSESNVLNGGK---------PGPHHIT---GNGVGFKP 252 Query: 249 WPIIRDLVDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQTVSPEVKNI 308 + D+++ + V+ ++ +++ + L++ ++G A L + + Sbjct: 253 DILDLDVMEKVLEVSSEDAVNMARVLALKEGLMVGISSGANTVAALRLAQLPENKGKLIV 312 Query: 309 CIVLSGGNVDLTSSI 323 + S G L+S + Sbjct: 313 TVHPSFGERYLSSVL 327 >2EGU-A nrPDB Length = 308 Score = 221 bits (562), Expect = 5e-58, Method: Composition-based stats. Identities = 73/318 (22%), Positives = 131/318 (41%), Gaps = 21/318 (6%) Query: 12 VEKAHINIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVRSLVPDA 71 + + +I + I TP + + + +++ K E S K R AL + + Sbjct: 1 MARTVNSITELIGDTPAVKLNRIVDEDSADVYLKLEFMNPGSSVKDRIALAMIEAAEKAG 60 Query: 72 LERKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYCEPS 131 + +V +SGN G L A +G A +V+P T ++ ++AYGA +V + Sbjct: 61 KLKPGDTIVEPTSGNTGIGLAMVAAAKGYKAVLVMPDTMSLERRNLLRAYGAELVLTPGA 120 Query: 132 DESRENVAK--RVTEETEGIMVHPNQEPAVIA-GQGTIALEVLNQV-PLVDALVVPVGGG 187 R +AK + E M + A + T E++ Q+ +DA V VG G Sbjct: 121 QGMRGAIAKAEELVREHGYFMPQQFKNEANPEIHRLTTGKEIVEQMGDQLDAFVAGVGTG 180 Query: 188 GMLAGIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGVKSSIGLN 247 G + G ++ P++K+YA EP+++ ++ P G IG Sbjct: 181 GTITGAGKVLREAYPNIKIYAVEPADS----------PVLSGGKPGPHKIQG----IGAG 226 Query: 248 TWPIIRD--LVDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQTVSPEV 305 P I D + D + TVT +E A + +L ++G + A L + + Sbjct: 227 FVPDILDTSIYDGVITVTTEEAFAAARRAAREEGILGGISSGAAIHAALK-VAKELGKGK 285 Query: 306 KNICIVLSGGNVDLTSSI 323 K + I+ S G L++ + Sbjct: 286 KVLAIIPSNGERYLSTPL 303 >5XA2-A nrPDB Length = 309 Score = 218 bits (554), Expect = 4e-57, Method: Composition-based stats. Identities = 66/310 (21%), Positives = 116/310 (37%), Gaps = 21/310 (6%) Query: 21 DSIHLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVRSLVPDALERKPKAVV 80 +SI TP++ + L + K E S K R + + VV Sbjct: 9 ESIGRTPLVQINRLTAGLSSRVLAKIEGRNPAYSVKCRIGAAMIWDAEQSGKLKPGMHVV 68 Query: 81 THSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYCEPSDESRENV-- 138 +SGN G AL + G + +P+T +++ ++++GA +V +D + + Sbjct: 69 EPTSGNTGIALAFVCAARGYKLTLTMPETMSIERRMMLKSFGADLVLTPGADGMKGAISK 128 Query: 139 AKRVTEETEGIMVHPNQEPAVIAGQ-GTIALEVLNQV-PLVDALVVPVGGGGMLAGIAIT 196 A+ + + + + PA A T E+ N VD V VG GG + G+A Sbjct: 129 AEELAAQPGWFIPQQFKNPANPAIHVKTTGPEIWNDTEGQVDVFVAGVGTGGTITGVARF 188 Query: 197 VK-ALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGVKSSIGLNTWP--IIR 253 +K K V V A EP A G+ IG P R Sbjct: 189 LKHEKKHPVHVVAVEP-AASPVLAGGPAGRH-------------KIQGIGAGFVPDTFDR 234 Query: 254 DLVDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQTVSPEVKNICIVLS 313 +VD+I +VT+DE + + + + G +A L + + ++ Sbjct: 235 SVVDEILSVTDDEAIETARKLAMEEGISCGISCGAAMAGALKVAARPEFAGKTIVTVLPD 294 Query: 314 GGNVDLTSSI 323 G L++++ Sbjct: 295 AGERYLSTAL 304 >3X43-A nrPDB Length = 332 Score = 216 bits (549), Expect = 2e-56, Method: Composition-based stats. Identities = 76/317 (23%), Positives = 127/317 (40%), Gaps = 25/317 (7%) Query: 15 AHINIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVRSLVPDALER 74 +I D+I TP++ + +++ K E F GS K R AL+ V L + Sbjct: 3 LFNSILDTIGRTPIVRLQRMA-PEHTSVYVKVESFNPGGSVKDRLALSVVLDAEAKGLLK 61 Query: 75 KPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYCEPSDES 134 +V +SGN G AL A G V+ T ++ I+AYG +V S Sbjct: 62 PGDTIVECTSGNVGIALAMVAAARGYRFVAVMGDTYSVERRKLIRAYGGKLVLFPGHLGS 121 Query: 135 REN--VAKRVTEETEGIMVHPNQEPAVIA-GQGTIALEVLNQVP--LVDALVVPVGGGGM 189 + +A + E+ PA + + T A E+L +D V G G Sbjct: 122 KGGNLIADELAEKYGWFRARQFDNPANPSYHRETTASEILADFAGKRLDHFVTGFGTTGT 181 Query: 190 LAGIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGVKSSIGLNTW 249 L G+ ++ +P V+V A EPSNA +G+ P+ + N Sbjct: 182 LTGVGQMLRVARPEVRVVALEPSNA----AMLARGEWSPHQI----------QGLAPNFV 227 Query: 250 P--IIRDLVDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQTVSPEVKN 307 P + R ++DD+ T+ E + ++ + + +AG VA LS +PE Sbjct: 228 PGVLDRSVIDDLVTMDEVTARDTSRRLAAEEGIFAGISAGATVATALS--IAEHAPEGTV 285 Query: 308 ICIVLSG-GNVDLTSSI 323 + +L G L++ + Sbjct: 286 LLAMLPDTGERYLSTFL 302 >4LMA-A nrPDB Length = 326 Score = 215 bits (548), Expect = 2e-56, Method: Composition-based stats. Identities = 71/320 (22%), Positives = 134/320 (41%), Gaps = 24/320 (7%) Query: 14 KAHINIRDSIHLTPVLTSSILNQLTGR--NLFFKCELFQKTGSFKIRGALNAVRSLVPDA 71 + ++ + + TP++ + + Q G + K E S K R + + S Sbjct: 9 RIAHDVTELVGRTPLVQLNRIPQAEGCLGRIVMKLEGMNPAASVKDRIGTHMINSAEKAG 68 Query: 72 LERKPKAV-VTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYCEP 130 L V V +SGN G AL A +G + +P+T ++ ++AYGA++ Sbjct: 69 LINPETTVLVEPTSGNTGIALAMTAAAKGYRLILTMPETMSLERRAMLKAYGATLELTPG 128 Query: 131 SDESRENV--AKRVTEETEGIM-VHPNQEPAVIA-GQGTIALEVLNQV-PLVDALVVPVG 185 S + + A+++ + G + + P+ + T A E+ VD +V VG Sbjct: 129 SQGMKGAILRAQQIVDSIPGAYMLQQFRNPSNPEIHRLTTAEEIWQDTEGQVDFIVAGVG 188 Query: 186 GGGMLAGIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGVKSSIG 245 GG + G+A +K+ KPS +V A EP N+ ++ P G IG Sbjct: 189 TGGTITGVAEVIKSRKPSFQVVAVEPFNS----------PVISGGNPGPHKIQG----IG 234 Query: 246 LNTWPIIR--DLVDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQTVSP 303 P + DL+D++ TV+++E + + + LL ++G + A + + + Sbjct: 235 AGFIPEVLRTDLIDEVITVSDEEAFQFGRRLAKEEGLLSGISSGANLCAAIQLAQRPENE 294 Query: 304 EVKNICIVLSGGNVDLTSSI 323 + I S G L++ + Sbjct: 295 GKLIVVIQPSFGERYLSTLM 314 >4H27-A nrPDB Length = 364 Score = 215 bits (548), Expect = 2e-56, Method: Composition-based stats. Identities = 79/307 (25%), Positives = 139/307 (45%), Gaps = 16/307 (5%) Query: 25 LTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVRSLVPDALERKPKAVVTHSS 84 TP+ S L+++ G +++ K + Q +GSFKIRG + ++ V SS Sbjct: 46 KTPIRDSMALSKMAGTSVYLKMDSAQPSGSFKIRG----IGHFCKRWAKQGCAHFVCSSS 101 Query: 85 GNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYCEPSDESRENVAKRVTE 144 GN G A YAA+ G+PA IVVP T P ++ GA++ + +AK + + Sbjct: 102 GNAGMAAAYAARQLGVPATIVVPGTTPALTIERLKNEGATVKVVGELLDEAFELAKALAK 161 Query: 145 ETE-GIMVHPNQEPAVIAGQGTIALEVLNQV-PLVDALVVPVGGGGMLAGIAITVKAL-K 201 + + P +P + G +I E+ + A+ + VGGGG+L G+ ++ + Sbjct: 162 NNPGWVYIPPFDDPLIWEGHASIVKELKETLWEKPGAIALSVGGGGLLCGVVQGLQEVGW 221 Query: 202 PSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGV-KSSIGLNTWPIIRDLVDDIF 260 V V A E A + + GKL+ +L ++A + ++G + ++ Sbjct: 222 GDVPVIAMETFGAHSFHAATTAGKLV-SLPKITSVAKALGVKTVGAQALKLFQEHPIFSE 280 Query: 261 TVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQTV-------SPEVKNICIVLS 313 +++ E A + + K+L+EP G +AAV S Q + +P + IV Sbjct: 281 VISDQEAVAAIEKFVDDEKILVEPACGAALAAVYSHVIQKLQLEGNLRTPLPSLVVIVCG 340 Query: 314 GGNVDLT 320 G N+ L Sbjct: 341 GSNISLA 347 >4AEC-A nrPDB Length = 430 Score = 213 bits (543), Expect = 8e-56, Method: Composition-based stats. Identities = 62/321 (19%), Positives = 125/321 (38%), Gaps = 22/321 (6%) Query: 11 DVEKAHINIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVRSLVPD 70 D N+ I TP++ + + + N+ K E+ + S K R + V Sbjct: 109 DGLNIADNVSQLIGKTPMVYLNSIAKGCVANIAAKLEIMEPCCSVKDRIGYSMVTDAEQK 168 Query: 71 ALERKPKAV-VTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYCE 129 K+V V +SGN G L + A G + +P + +++ ++A+GA +V + Sbjct: 169 GFISPGKSVLVEPTSGNTGIGLAFIAASRGYRLILTMPASMSMERRVLLKAFGAELVLTD 228 Query: 130 PSDESRENV--AKRVTEETEGIM-VHPNQEPAVIA-GQGTIALEVLNQV-PLVDALVVPV 184 P+ V A+ + + T + PA T E+ + VD V + Sbjct: 229 PAKGMTGAVQKAEEILKNTPDAYMLQQFDNPANPKIHYETTGPEIWDDTKGKVDIFVAGI 288 Query: 185 GGGGMLAGIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGVKSSI 244 G GG + G+ +K P +V EP+ +D ++ P G I Sbjct: 289 GTGGTITGVGRFIKEKNPKTQVIGVEPTESD----------ILSGGKPGPHKIQG----I 334 Query: 245 GLNTWP--IIRDLVDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQTVS 302 G P + + ++D++ ++ +E + + + L++ ++G AA + + + Sbjct: 335 GAGFIPKNLDQKIMDEVIAISSEEAIETAKQLALKEGLMVGISSGAAAAAAIKVAKRPEN 394 Query: 303 PEVKNICIVLSGGNVDLTSSI 323 + S G L++ + Sbjct: 395 AGKLIAVVFPSFGERYLSTPL 415 >5J5V-A nrPDB Length = 323 Score = 209 bits (532), Expect = 1e-54, Method: Composition-based stats. Identities = 65/312 (20%), Positives = 121/312 (38%), Gaps = 21/312 (6%) Query: 22 SIHLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVRSLVPDALERKPKAVVT 81 +I TP++ + + + K E + S K R N + + + +V Sbjct: 11 TIGHTPLVRLNRIGNG---RILAKVESRNPSFSVKCRIGANMIWDAEKRGVLKPGVELVE 67 Query: 82 HSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYCEPSDESRENV--A 139 +SGN G AL Y A G + +P+T ++ ++A GA++V E + + + A Sbjct: 68 PTSGNTGIALAYVAAARGYKLTLTMPETMSIERRKLLKALGANLVLTEGAKGMKGAIQKA 127 Query: 140 KRVTEETEGIM--VHPNQEPAVIA-GQGTIALEVLNQVP-LVDALVVPVGGGGMLAGIAI 195 + + + PA + T E+ VD + VG GG L G++ Sbjct: 128 EEIVASNPEKYLLLQQFSNPANPEIHEKTTGPEIWEDTDGQVDVFIAGVGTGGTLTGVSR 187 Query: 196 TVKALKPSVKVY--AAEPSNADDCYQSKLKGKLMPNLYPPETIADGVKSSIGLNTWP--I 251 +K K + A EP+++ Q+ ++ P + IG P + Sbjct: 188 YIKGTKGKTDLISVAVEPTDSPVIAQALAGEEIKPGPHKI--------QGIGAGFIPANL 239 Query: 252 IRDLVDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQTVSPEVKNICIV 311 LVD + +T +E + + E +L ++G VAA L + I+ Sbjct: 240 DLKLVDKVIGITNEEAISTARRLMEEEGILAGISSGAAVAAALKLQEDESFTNKNIVVIL 299 Query: 312 LSGGNVDLTSSI 323 S G L++++ Sbjct: 300 PSSGERYLSTAL 311 >5XEM-A nrPDB Length = 310 Score = 209 bits (531), Expect = 2e-54, Method: Composition-based stats. Identities = 68/314 (21%), Positives = 121/314 (38%), Gaps = 16/314 (5%) Query: 12 VEKAHINIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVRSLVPDA 71 + ++ D I TP++ + ++ G ++ K E S K R AL + + Sbjct: 3 LGSLANSVIDLIGNTPLVKINNID-TFGNEIYVKLEGSNPGRSTKDRIALKMIEEAEKEG 61 Query: 72 LERKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYCEPS 131 L K ++ +SGN G L ++ IV+P T + ++AYG ++ + S Sbjct: 62 LIDKDTVIIEATSGNTGIGLAMICAVKNYKLKIVMPDTMSIERIQLMRAYGTEVILTDGS 121 Query: 132 DESRENVAK-RVTEETEGIMVHPNQEPAV---IAGQGTIALEVLNQV-PLVDALVVPVGG 186 + + K ++ E PNQ V A T A E+L + VD + G Sbjct: 122 LGMKACLEKLEELKKNEKKYFVPNQFTNVNNPKAHYETTAEEILKDLNNKVDVFICGTGT 181 Query: 187 GGMLAGIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGVKSSIGL 246 GG +G A +K P++K + EP+++ L+ Y G+ SIG Sbjct: 182 GGSFSGTAKKLKEKLPNIKTFPVEPASS----------PLLSKGYIGPHKIQGMGMSIGG 231 Query: 247 NTWPIIRDLVDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQTVSPEVK 306 L DDI +D+ + + + +L + G A L + +K Sbjct: 232 IPAVYDGSLADDILVCEDDDAFEMMRELSFKEGILGGISTGATFKAALDYSKENADKGLK 291 Query: 307 NICIVLSGGNVDLT 320 + + G L+ Sbjct: 292 IVVLSTDSGEKYLS 305 >2ISQ-A nrPDB Length = 320 Score = 204 bits (520), Expect = 3e-53, Method: Composition-based stats. Identities = 63/318 (19%), Positives = 129/318 (40%), Gaps = 22/318 (6%) Query: 14 KAHINIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVRSLVPDALE 73 + ++ + I TP++ + + + + K E+ + S K R + + L Sbjct: 2 RIAKDVTELIGNTPLVYLNNVAEGCVGRVAAKLEMMEPCSSVKDRIGFSMISDAEKKGLI 61 Query: 74 RKPKAV-VTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYCEPSD 132 + ++V + +SGN G L + A +G I +P + +++ + A+G +V +P+ Sbjct: 62 KPGESVLIEPTSGNTGVGLAFTAAAKGYKLIITMPASMSTERRIILLAFGVELVLTDPAK 121 Query: 133 ESRENVAKR---VTEETEGIMVHPNQEPAVIA-GQGTIALEVLNQV-PLVDALVVPVGGG 187 + +AK + + G M+ + PA T E+ +D V +G G Sbjct: 122 GMKGAIAKAEEILAKTPNGYMLQQFENPANPKIHYETTGPEIWKGTGGKIDGFVSGIGTG 181 Query: 188 GMLAGIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGVKSSIGLN 247 G + G +K +VK+Y EP ++ ++ P G IG Sbjct: 182 GTITGAGKYLKEQNANVKLYGVEP----------VESAILSGGKPGPHKIQG----IGAG 227 Query: 248 TWPIIR--DLVDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQTVSPEV 305 P + DL+D++ V+ DE + + + LL+ ++G AA + + + Sbjct: 228 FIPSVLNVDLIDEVVQVSSDESIDMARQLALKEGLLVGISSGAAAAAAIKLAQRPENAGK 287 Query: 306 KNICIVLSGGNVDLTSSI 323 + I S G L++ + Sbjct: 288 LFVAIFPSFGERYLSTVL 305 >2RKB-A nrPDB Length = 318 Score = 204 bits (518), Expect = 6e-53, Method: Composition-based stats. Identities = 79/322 (24%), Positives = 138/322 (42%), Gaps = 34/322 (10%) Query: 25 LTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVRSLVPDALERKPKAVVTHSS 84 +TP+L S L+Q+ G +F KCE Q +GSFKIRG + + ++ + +V S Sbjct: 7 VTPLLESWALSQVAGMPVFLKCENVQPSGSFKIRG----IGHFCQEMAKKGCRHLVCSSG 62 Query: 85 GNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYCEPSDESRENVAKRVTE 144 GN G A YAA+ GIPA IV+P++ +Q GA + + A+ + + Sbjct: 63 GNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTGKVWDEANLRAQELAK 122 Query: 145 ETEGIMVHPNQEPAVIAGQGTIALEV--LNQVPLVDALVVPVGGGGMLAGIAITVKALKP 202 V P P + G ++ E+ + + P ++ GGG + +A ++ Sbjct: 123 RDGWENVPPFDHPLIWKGHASLVQELKAVLRTPPGALVLAVGGGGLLAGVVAGLLEVGWQ 182 Query: 203 SVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGVKSSIGLNT-----------WPI 251 V + A E A + GKL+ V S+G T I Sbjct: 183 HVPIIAMETHGAHCFNAAITAGKLVTLPD-----ITSVAKSLGAKTVAARALECMQVCKI 237 Query: 252 IRDLVDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLS------QHFQTVSPEV 305 ++V+D V+ A Q + + ++L+EP G +AA+ S Q + P + Sbjct: 238 HSEVVEDTEAVS------AVQQLLDDERMLVEPACGAALAAIYSGLLRRLQAEGCLPPSL 291 Query: 306 KNICIVLSGGNVDLTSSITWVK 327 ++ +++ GGN + + +K Sbjct: 292 TSVVVIVCGGNNINSRELQALK 313 >4LMB-A nrPDB Length = 322 Score = 203 bits (516), Expect = 1e-52, Method: Composition-based stats. Identities = 72/317 (22%), Positives = 127/317 (40%), Gaps = 24/317 (7%) Query: 17 INIRDSIHLTPVLTSSI--LNQLTGRNLFFKCELFQKTGSFKIRGALNAVRSLVPDALER 74 +I + TP++ + + + + K E S K R ++ V L Sbjct: 12 RDITQLVGRTPLVQLNRIPVAEGVKARIVVKLESMNPAASVKDRIGVSMVEDAEAAGLIH 71 Query: 75 KPKAV-VTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYCEPS-- 131 K + V +SGN G AL A +G + +P+T ++ ++AYGA + S Sbjct: 72 PDKTILVEPTSGNTGIALAMVAAAKGYRLVLTMPETMSLERRAMLKAYGAQLELTPGSQG 131 Query: 132 DESRENVAKRVTEETEGIM-VHPNQEPAVIA-GQGTIALEVLNQVPL-VDALVVPVGGGG 188 E A+ + E T + + PA + T A E+ VD ++ VG GG Sbjct: 132 MEGAITRAEEIVENTPNAYSLQQFRNPANPKIHRETTAEEIWADTDGLVDIVIGGVGTGG 191 Query: 189 MLAGIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGVKSSIGLNT 248 + GIA T+K +P + A EPSN+ ++ P G IG Sbjct: 192 TITGIAETIKPRRPQFQAIAVEPSNS----------PVLSGGQPGPHKIQG----IGAGF 237 Query: 249 WPII--RDLVDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQTVSPEVK 306 P I +L+D++ V + E + + + LL +AG + A + + + + Sbjct: 238 IPAIFRPELIDEVIIVDDTEAFAYARRLARQEGLLSGISAGAALWAAIQVGKRPENEDKL 297 Query: 307 NICIVLSGGNVDLTSSI 323 + I S G L++++ Sbjct: 298 IVMIQPSFGERYLSTAL 314 >5D84-A nrPDB Length = 326 Score = 201 bits (511), Expect = 4e-52, Method: Composition-based stats. Identities = 61/333 (18%), Positives = 124/333 (37%), Gaps = 31/333 (9%) Query: 9 FADVEKAHINIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVRSLV 68 + H ++ DS+ TP++ L +F K E GS K R A + + Sbjct: 2 IEKSQACHDSLLDSVGQTPMVQLHQLFPK--HEVFAKLEYMNPGGSMKDRPAKYIIEHGI 59 Query: 69 PDALERKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYC 128 L + ++ +SGN G AL AK++G+ VV I++YGA++ Sbjct: 60 KHGLITENTHLIESTSGNLGIALAMIAKIKGLKLTCVVDPKISPTNLKIIKSYGANVEMV 119 Query: 129 EPSDESRENVAKRVTEETE-------GIMVHPNQEPAVIA-GQGTIALEVLNQVP-LVDA 179 E D + R+ + E ++ E++ + +D Sbjct: 120 EEPDAHGGYLMTRIAKVQELLATIDDAYWINQYANELNWQSHYHGAGTEIVETIKQPIDY 179 Query: 180 LVVPVGGGGMLAGIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADG 239 V PV G + G++ +K + P+ ++ A + + + +L Sbjct: 180 FVAPVSTTGSIMGMSRKIKEVHPNAQIVAVDAKGSVIFGDKPINREL------------- 226 Query: 240 VKSSIGLNTWPII--RDLVDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQH 297 IG + P I R ++ + V + + + + + + + G + A + Q Sbjct: 227 --PGIGASRVPEILNRSEINQVIHVDDYQSALGCRKLIDYEGIFAGGSTG-SIIAAIEQL 283 Query: 298 FQTVSPEVKNICIVLSGGN--VDLTSSITWVKQ 328 ++ + I+ G+ +DL S TW+++ Sbjct: 284 ITSIEEGATIVTILPDRGDRYLDLVYSDTWLEK 316 >5I7O-A nrPDB Length = 326 Score = 199 bits (507), Expect = 9e-52, Method: Composition-based stats. Identities = 66/320 (20%), Positives = 121/320 (37%), Gaps = 34/320 (10%) Query: 16 HINIRDSIHLTPVLTSSILNQLTG-------RNLFFKCELFQKTGSFKIRGALNAVRSLV 68 + ++ ++ TP++ L+ L+ K E TGS K R A+ + Sbjct: 7 YDSLLQALGNTPLVGLQRLSPRWDDGRDGPHVRLWAKLEDRNPTGSIKDRPAVRMIEQAE 66 Query: 69 PDALERKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYC 128 D L R ++ +SGN G +L AA+L+G V+P+ ++ ++ YGA I++ Sbjct: 67 ADGLLRPGATILEPTSGNTGISLAMAARLKGYRLICVMPENTSVERRQLLELYGAQIIFS 126 Query: 129 --EPSDESRENVAKRVTEETE-GIMVHPNQEPAVI-AGQGTIALEVLNQVPLVDALVVPV 184 E + AK + +M++ PA + E+L +P + V + Sbjct: 127 AAEGGSNTAVATAKELAATNPSWVMLYQYGNPANTDSHYCGTGPELLADLPEITHFVAGL 186 Query: 185 GGGGMLAGIAITVKALKPSVKVYAAEPSNADDCYQSK-LKGKLMPNLYPPETIADGVKSS 243 G G L G ++ +VK+ AAEP + Y + + +P LY PE + + S Sbjct: 187 GTTGTLMGTGRFLREHVANVKIVAAEPRYGEGVYALRNMDEGFVPELYDPEILT--ARYS 244 Query: 244 IGLNTWPIIRDLVDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGV--AAVLSQHFQTV 301 +G VD T+ + + + G + A + Sbjct: 245 VGA---------VD---------AVRRTRELVHTEGIFAGISTGAVLHAALGVGAGALAA 286 Query: 302 SPEVKNICIVLSGGNVDLTS 321 +V G L++ Sbjct: 287 GERADIALVVADAGWKYLST 306 >5B1I-A nrPDB Length = 311 Score = 192 bits (487), Expect = 2e-49, Method: Composition-based stats. Identities = 59/310 (19%), Positives = 114/310 (36%), Gaps = 20/310 (6%) Query: 19 IRDSIHLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVRSLVPDALERKPKA 78 +++ I TP++ + +++ K E+F GS R + + Sbjct: 6 VQELIGHTPLMALP-IEVPNHSHIYAKLEMFNPGGSIADRLGAYLIEDGLQRGRVNAKTT 64 Query: 79 VVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYC--EPSDESRE 136 ++ ++GN G L A + + +VVP+ K++ +QA GA IV+ E + Sbjct: 65 IIEPTAGNTGIGLALATQAHHLRTILVVPEKFSMEKQVLMQALGAEIVHTPSEEGIKGAI 124 Query: 137 NVAKRVTEETEGIMVH-PNQEPAVI-AGQGTIALEVLNQVP-LVDALVVPVGGGGMLAGI 193 A+ + V + PA A T+A E+L +P + A V G GG AG+ Sbjct: 125 RKAEALAATISNSYVPMQFKNPANPAAYYHTLAPEILADMPAPITAFVAGAGSGGTFAGV 184 Query: 194 AITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGVKSSIGLNTWPIIR 253 A ++A + K EP + ++ +G+ + +R Sbjct: 185 AAYLQAQDSATKAVVVEPEGS-----------ILNGGPAHAHRTEGIGVEFIPPFFDQVR 233 Query: 254 DLVDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQTVSPEVKNICIVLS 313 +D T+ +++ + + LLI ++ A Q + + I Sbjct: 234 --IDQTLTIADNDAFAQVRHLARDHGLLIGSSS-GAALAASLQLATNLPANSHIVTIFPD 290 Query: 314 GGNVDLTSSI 323 L+ I Sbjct: 291 SSERYLSQKI 300 >3T4P-A nrPDB Length = 334 Score = 185 bits (469), Expect = 2e-47, Method: Composition-based stats. Identities = 62/326 (19%), Positives = 117/326 (35%), Gaps = 23/326 (7%) Query: 6 CISFADVEKAHINIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVR 65 F + +I I TP L + LN T + K E S K R Sbjct: 2 AAPFDKSKNVAQSIDQLIGQTPALYLNKLNN-TKAKVVLKMECENPMASVKDRLGFAIYD 60 Query: 66 SLVPDALERKPKAVV-THSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGAS 124 + K++V SSGN G +L + + G I +P++ ++ ++ +GA Sbjct: 61 KAEKEGKLIPGKSIVVESSSGNTGVSLAHLGAIRGYKVIITMPESMSLERRCLLRIFGAE 120 Query: 125 IVYCEP--SDESRENVAKRVTEETE-GIMVHPNQEPAV-IAGQGTIALEVLNQVPL-VDA 179 ++ + +AK++ ++ + + T E+ Q VD Sbjct: 121 VILTPAALGMKGAVAMAKKIVAANPNAVLADQFATKYNALIHEETTGPEIWEQTNHNVDC 180 Query: 180 LVVPVGGGGMLAGIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADG 239 + VG GG L G+A +K + ++ A EP+ + ++ P G Sbjct: 181 FIAGVGTGGTLTGVARALKKMGSHARIVAVEPTES----------PVLSGGKPGPHKIQG 230 Query: 240 VKSSIGLNTWPII--RDLVDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQH 297 IG P + R L+D++ V D+ + + + G V A L Sbjct: 231 ----IGPGFVPDVLDRSLIDEVLCVAGDDAIETALKLTRSDGVFCGFSGGANVYAALKIA 286 Query: 298 FQTVSPEVKNICIVLSGGNVDLTSSI 323 + + ++ S G L++++ Sbjct: 287 ERPEMEGKTIVTVIPSFGERYLSTTL 312 >5B55-A nrPDB Length = 340 Score = 182 bits (462), Expect = 2e-46, Method: Composition-based stats. Identities = 63/322 (19%), Positives = 117/322 (36%), Gaps = 26/322 (8%) Query: 13 EKAHINIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVRSLVPDAL 72 +K + + + TP+L + R +F K E + TGS K R A ++ Sbjct: 7 QKKMKYLENLVGKTPMLELIFDYKGEERRIFVKNESYNLTGSIKDRMAFYTLKKAYEKNE 66 Query: 73 ERKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYC---E 129 +K +V +SGN G A + + G P I +P + +K I+++GA I+ E Sbjct: 67 IKKGAPIVEATSGNTGIAFSAMGAILGHPVIIYMPDWMSEERKSLIRSFGAKIILVSRKE 126 Query: 130 PSDESRENVAKRVTEETEGIMVH-PNQEPAVI-AGQGTIALEVLNQVP----LVDALVVP 183 K + + A I LE++N++ +D V Sbjct: 127 GGFLGSIEKTKEFAKNNPDTYLPSQFSNLYNSEAHYYGIGLEIVNEMKSLNLNIDGFVAG 186 Query: 184 VGGGGMLAGIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGVKSS 243 VG GG + GI +K + K+ EP N+ P L +A Sbjct: 187 VGTGGTVMGIGKRIKENFSNAKICPLEPLNS-------------PTLSTGYKVAKHRIEG 233 Query: 244 IGLNTWPIIRDL--VDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQTV 301 I P + L +D++ +V + + Q + + L + ++G L + Sbjct: 234 ISNEFIPDLVKLDKLDNVVSVDDGDAIVMAQKLA-KCGLGVGISSGANFIGALM-LQNKL 291 Query: 302 SPEVKNICIVLSGGNVDLTSSI 323 + + + L++ + Sbjct: 292 GKDSVIVTVFPDDNKKYLSTDL 313 >5XCN-X nrPDB Length = 350 Score = 177 bits (449), Expect = 5e-45, Method: Composition-based stats. Identities = 70/311 (22%), Positives = 119/311 (38%), Gaps = 19/311 (6%) Query: 22 SIHLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVRSLVPDALERKPKAVVT 81 SI TP++ N+ K E + S K R N V D K K +V Sbjct: 44 SIGNTPLVRLKHFGHN--GNVVVKIEGRNPSYSVKCRIGANMVWQAEKDGTLTKGKEIVD 101 Query: 82 HSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYCEPSDESRENVAKR 141 +SGN G AL Y A G + +P+T +K + G ++V E + ++ +AK Sbjct: 102 ATSGNTGIALAYVAAARGYKITLTMPETMSLERKRLLCGLGVNLVLTEGAKGAKGAIAKA 161 Query: 142 ----VTEETEGIMVHPNQEPAVIA-GQGTIALEVLNQVP-LVDALVVPVGGGGMLAGIAI 195 ++ + +M+ + PA + T E+ VD +V VG GG + GI+ Sbjct: 162 EEIVASDPSRYVMLKQFENPANPQIHRETTGPEIWKDTDGKVDVVVAGVGTGGSITGISR 221 Query: 196 TVK-ALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGVKSSIGLNTWPIIRD 254 +K + A EP + Q+ ++ P + IG P D Sbjct: 222 AIKLDFGKQITSVAVEPVESPVISQTLAGEEVKPGPHKI--------QGIGAGFIPKNLD 273 Query: 255 L--VDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQTVSPEVKNICIVL 312 L +D + TV D + + +L ++G VAA + + I+ Sbjct: 274 LSIIDRVETVDSDTALATARRLMAEEGILAGISSGAAVAAADRLAKLPEFADKLIVVILP 333 Query: 313 SGGNVDLTSSI 323 S L++++ Sbjct: 334 SASERYLSTAL 344 >2ZSJ-A nrPDB Length = 352 Score = 172 bits (436), Expect = 2e-43, Method: Composition-based stats. Identities = 73/323 (22%), Positives = 129/323 (39%), Gaps = 29/323 (8%) Query: 24 HLTPVLTSSILNQLTG--RNLFFKCELFQKTGSFKIRGALNAVRSLVPDALERKPKAVVT 81 TP++ + L + G ++ K E TGSFK RG A+ A+E +AV+ Sbjct: 29 GNTPLIEADNLARAIGFKGKIYLKYEGLNPTGSFKDRGMTLAIS----KAVEAGKRAVIC 84 Query: 82 HSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQA-YGASIVYCEPSDESRENVAK 140 S+GN + A G+ AY+++P+ A KL+ YGA ++ + + + N+ + Sbjct: 85 ASTGNTSASAAAYAARAGLRAYVLLPKGAVAIGKLSQAMIYGAKVLAIQGTFDDALNIVR 144 Query: 141 RVTEETEGIMVHPNQEPAVIAGQGTIALEVLNQVPLV-DALVVPVGGGGMLAGIAITVKA 199 ++ E +V+ + P I GQ T A E+ + + D +PVG G + K Sbjct: 145 KIGENFPVEIVN-SVNPYRIEGQKTAAFEICDTLGEAPDYHFIPVGNAGNITAYWKGFKI 203 Query: 200 LKPSVKV------YAAEPSNADDCYQSKLKGKLMPNLYPPETIADGVKSSIGLNTWPIIR 253 K+ + A + + P+TIA +K +W Sbjct: 204 YYEEGKITKLPRMMGWQAEGAAPIVKGYP-------IKNPQTIATAIKIG-NPYSWKSAL 255 Query: 254 DLVDD----IFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQTVSPEVKNIC 309 + I V++ EI A +L+ + EP + VA ++ + + + Sbjct: 256 KAAQESGGKIDAVSDSEILYAYKLIASTEGVFCEPASAASVAGLIKLVREGFFKGGEVVT 315 Query: 310 IVLSGGNVDLTSSITWVKQAERP 332 L+G L T +K E P Sbjct: 316 CTLTGNG--LKDPDTAIKVCEEP 336 >2D1F-A nrPDB Length = 360 Score = 170 bits (431), Expect = 6e-43, Method: Composition-based stats. Identities = 70/317 (22%), Positives = 126/317 (39%), Gaps = 26/317 (8%) Query: 24 HLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVRSLVPDALERKPKAVVTHS 83 TP++ ++ L++ TG + K E TGSFK RG AV DAL +AV+ S Sbjct: 37 GGTPLIAATNLSKQTGCTIHLKVEGLNPTGSFKDRGMTMAVT----DALAHGQRAVLCAS 92 Query: 84 SGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQ-AYGASIVYCEPSDESRENVAKRV 142 +GN + A GI +++PQ KLA +GA I+ + + + +A+++ Sbjct: 93 TGNTSASAAAYAARAGITCAVLIPQGKIAMGKLAQAVMHGAKIIQIDGNFDDCLELARKM 152 Query: 143 TEETEGIMVHPNQEPAVIAGQGTIALEVLNQVPLV-DALVVPVGGGGMLAGIAITVKALK 201 + I + + P I GQ T A E+++ + D +PVG G + Sbjct: 153 AADFPTISLVNSVNPVRIEGQKTAAFEIVDVLGTAPDVHALPVGNAGNITAYWKGYTEYH 212 Query: 202 ------PSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGVKSSIGLNTWPIIRDL 255 ++ + + A + G+ + + PETIA ++ +W + Sbjct: 213 QLGLIDKLPRMLGTQAAGAAPL----VLGEPVSH---PETIATAIRIG-SPASWTSAVEA 264 Query: 256 VDD----IFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQTVSPEVKNICIV 311 +++EI A LV + +EP + +A +L + Sbjct: 265 QQQSKGRFLAASDEEILAAYHLVARVEGVFVEPASAASIAGLLKAIDDGWVARGSTVVCT 324 Query: 312 LSGGNVDLTSSITWVKQ 328 ++G L T +K Sbjct: 325 VTGNG--LKDPDTALKD 339 >5YGR-A nrPDB Length = 404 Score = 163 bits (412), Expect = 1e-40, Method: Composition-based stats. Identities = 61/323 (18%), Positives = 124/323 (38%), Gaps = 43/323 (13%) Query: 15 AHINIRDSIHLTPVLTSSILNQLTG-RNLFFKCELFQKT-GSFKIRGALNAVRSLVPDAL 72 A + +TP+ + L+Q G ++ K E ++ +FK G AV + D L Sbjct: 35 AFHKKLPNYAVTPLHNLAHLSQRLGLGSIHIKDESWRFGLNAFKGLGGSYAVGKYLADKL 94 Query: 73 E-------------------RKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDC 113 + K VT + GNHG+ + +AA+ G+ A + +P+ + Sbjct: 95 QCDINSLSFAALNTPEIKEKIKDCVFVTATDGNHGRGVAWAAEQLGLKAVVYMPKGSSLI 154 Query: 114 KKLAIQAYGASIVYCEPSDESRENVAKRVTEETEGIMVHPNQEPA-------VIAGQGTI 166 + I+ +GA + + + +A R+ + +++ ++ G T+ Sbjct: 155 RAENIRHHGAECTITDLNYDDAVRLAHRMAQTKGWVLLQDTAWTGYEEIPTWIMQGYMTL 214 Query: 167 ALEVLNQV-----PLVDALVVPVGGGGMLAGI-AITVKALKPSVK-VYAAEPSNADDCYQ 219 A+E Q+ PL L++ G G + V+ ++ ++ + EP A+ YQ Sbjct: 215 AVEAYEQLAETNSPLPTHLILQAGVGSFAGSVMGYFVEKMQENIPNIIVVEPHQANCLYQ 274 Query: 220 SKLKGKLMPNLYPPE--TIADGVK-SSIGLNTWPIIRDLVDDIFTVTEDEIKCATQLVWE 276 S + P+ + TI G+ + +WPIIRD + + ++ Sbjct: 275 SAVMDDGQPHCVTGDMATIMAGLACGEPNIISWPIIRDNTSCFISADDCLAAKGMRISAA 334 Query: 277 -----RMKLLIEPTAGVGVAAVL 294 + + +GV + Sbjct: 335 PRPGTDTPFISGESGAIGVGLLY 357 >1UIN-A nrPDB Length = 351 Score = 162 bits (411), Expect = 1e-40, Method: Composition-based stats. Identities = 77/344 (22%), Positives = 134/344 (38%), Gaps = 37/344 (10%) Query: 12 VEKAHINIRDSIHLTPVLTS------------SILNQLTGRNLFFKCELFQKTGSFKIRG 59 + + + N+ TPV++ + G L+ K E TGSFK RG Sbjct: 5 LIERYRNLLPVSEKTPVISLLEGSTPLIPLKGPEEARKKGIRLYAKYEGLNPTGSFKDRG 64 Query: 60 ALNAVRSLVPDALERKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQ 119 AV A+E +AV S+GN + A GI A +V+P K+A Sbjct: 65 MTLAVS----KAVEGGAQAVACASTGNTAASAAAYAARAGILAIVVLPAGYVALGKVAQS 120 Query: 120 -AYGASIVYCEPSDESRENVAKRVTEETEGIMVHPNQEPAVIAGQGTIALEVLNQVPLV- 177 +GA IV E + + + +++TE +V+ + P + GQ T+A EV++++ Sbjct: 121 LVHGARIVQVEGNFDDALRLTQKLTEAFPVALVN-SVNPHRLEGQKTLAFEVVDELGDAP 179 Query: 178 DALVVPVGGGGMLAGIAITVKALKPSVK------VYAAEPSNADDCYQSKLKGKLMPNLY 231 +PVG G + + KA K + + + A + + Sbjct: 180 HYHALPVGNAGNITAHWMGYKAYHALGKAKRLPRMLGFQAAGAAPLVLGRP-------VE 232 Query: 232 PPETIADGVKSSIGLNTWPIIRDLVDD---IFTVTEDEIKCATQLVWERMKLLIEPTAGV 288 PET+A ++ + +R + I VT++EI A + + + EP + Sbjct: 233 RPETLATAIRIGNPASWQGAVRAKEESGGVIEAVTDEEILFAYRYLAREEGIFCEPASAA 292 Query: 289 GVAAVLSQHFQTVSPEVKNICIVLSGGNVDLTSSITWVKQAERP 332 +A V + + + L+G L T + AE P Sbjct: 293 AMAGVFKLLREGRLEPESTVVLTLTGHG--LKDPATAERVAELP 334 >4D9G-A nrPDB Length = 398 Score = 132 bits (333), Expect = 1e-31, Method: Composition-based stats. Identities = 62/350 (17%), Positives = 130/350 (37%), Gaps = 44/350 (12%) Query: 26 TPVLTSSILNQLTG-RNLFFKCELFQKT-GSFKIRGALNAVRSLVPD------------- 70 TP+ L L G + + K E + +FK+ G A+ L+ + Sbjct: 45 TPLCALDDLANLFGVKKILVKDESKRFGLNAFKMLGGAYAIAQLLCEKYHLDIETLSFEH 104 Query: 71 --ALERKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYC 128 + T + GNHG+ + +AA+ G A I +P+ + + AI GA + Sbjct: 105 LKNAIGEKMTFATTTDGNHGRGVAWAAQQLGQNAVIYMPKGSAQERVDAILNLGAECIVT 164 Query: 129 EPSDESRENVAKRVTEETEGIMVHPNQEPA-------VIAGQGTIALEVLNQVPLV---- 177 + + + + + ++ +V ++ G T+A E + Q+ + Sbjct: 165 DMNYDDTVRLTMQHAQQHGWEVVQDTAWEGYTKIPTWIMQGYATLADEAVEQMREMGVTP 224 Query: 178 DALVVPVGGGGMLAGIAITVKALK--PSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPET 235 +++ G G M G+ + + ++ EP AD Y+S +KG ++ T Sbjct: 225 THVLLQAGVGAMAGGVLGYLVDVYSPQNLHSIIVEPDKADCIYRSGVKGDIVNVGGDMAT 284 Query: 236 IADGVK-SSIGLNTWPIIRDLVDDIFTVTEDEIKCATQLV----WERMKLLIEPTA--GV 288 I G+ W I+R+ + + +++ +++ + G+ Sbjct: 285 IMAGLACGEPNPLGWEILRNCATQFISCQDSVAALGMRVLGNPYGNDPRIISGESGAVGL 344 Query: 289 GVAAVLSQHFQTVSPEVK-------NICIVLSGGNVDLTSSITWVKQAER 331 GV A + H Q S K + ++ + G+ D+ V + + Sbjct: 345 GVLAAVHYHPQRQSLMEKLALNKDAVVLVISTEGDTDVKHYREVVWEGKH 394 >3VSD-A nrPDB Length = 389 Score = 120 bits (301), Expect = 8e-28, Method: Composition-based stats. Identities = 59/303 (19%), Positives = 114/303 (37%), Gaps = 31/303 (10%) Query: 26 TPVLTSSILNQLTGRNLFFKCELFQK-TGSFKIRGALNAVRSLVPDALERKPKAVVTHSS 84 TP++ S L G ++ K E + + S R A+ + L K V +S Sbjct: 97 TPLVRS-RLQLPNGVRVWLKLEWYNPFSLSVADRPAVEIISRLSRR--VEKGSLVADATS 153 Query: 85 GNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYCEPSDESRENVAK--RV 142 N G AL+ A+L G A + +P A + KL + GA ++ + + + + + Sbjct: 154 SNFGVALSAVARLYGYRARVYLPGAAEEFGKLLPRLLGAQVIVDPEAPSTVHLLPRVMKD 213 Query: 143 TEETEGIMVHPNQEPAVIAGQG-TIALEVLNQVPL----VDALVVPVGGGGMLAGIAITV 197 ++ + V+ A A E+ Q + + +G G ++ A + Sbjct: 214 SKNEGFVHVNQFYNDANFEAHMRGTAREIFVQSRRGGLALRGVAGSLGTSGHMSAAAFYL 273 Query: 198 KALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGVKSSIGLNTWPIIRDLVD 257 +++ PS++ +P+ +G +P + ET W + D+ Sbjct: 274 QSVDPSIRAVLVQPA----------QGDSIPGIRRVET----------GMLWINMLDISY 313 Query: 258 DIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQTVSPEVKNICIVLSGGNV 317 + VT +E A V L+I P+ G V A+ + + + +V G Sbjct: 314 TLAEVTLEEAMEAVVEVARSDGLVIGPSGGAAVKALAKKAAEGDLEPGDYVVVVPDTGFK 373 Query: 318 DLT 320 L+ Sbjct: 374 YLS 376 >1E5X-A nrPDB Length = 486 Score = 110 bits (275), Expect = 9e-25, Method: Composition-based stats. Identities = 67/336 (19%), Positives = 119/336 (35%), Gaps = 30/336 (8%) Query: 6 CISFADVEKAHINIRDSIHLTPVLTSSILNQLT--GRNLFFKCELFQKTGSFKIRGALNA 63 I D+ A + + + + +L+ K TGSFK G Sbjct: 117 EIDDDDIVSAFE------GNSNLFWAERFGKQFLGMNDLWVKHCGISHTGSFKDLGMTVL 170 Query: 64 VRSLVP-DALERKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQ-AY 121 V + ++R V S+G+ AL+ GIP+ + +P +L A Sbjct: 171 VSQVNRLRKMKRPVVGVGCASTGDTSAALSAYCASAGIPSIVFLPANKISMAQLVQPIAN 230 Query: 122 GASIVYCEPSDESRENVAKRVTEETEGIMVHPNQEPAVIAGQGTIALEVLNQVP--LVDA 179 GA ++ + + + + +T E I + + + GQ T A+E+L Q + D Sbjct: 231 GAFVLSIDTDFDGCMKLIREITAELP-IYLANSLNSLRLEGQKTAAIEILQQFDWQVPDW 289 Query: 180 LVVPVGGGGMLAGIAITVK-----ALKPSV-KVYAAEPSNADDCYQSKLKG--KLMPNLY 231 ++VP G G + K L + ++ A+ +NA+ Y G P Sbjct: 290 VIVPGGNLGNIYAFYKGFKMCQELGLVDRIPRMVCAQAANANPLYLHYKSGWKDFKPMTA 349 Query: 232 PPE-----TIADGVKSSIGLNTWPIIRDLVDDIFTVTEDEIKCATQLVWERMKLLIEPTA 286 I D V + +V++ TE+E+ A + + I P Sbjct: 350 STTFASAIQIGDPVSIDRAVYALKKCNGIVEE---ATEEELMDAMAQ-ADSTGMFICPHT 405 Query: 287 GVGVAAVLSQHFQTVSPEVKNICIVLSGGNVDLTSS 322 GV + A+ Q V +V + + T S Sbjct: 406 GVALTALFKLRNQGVIAPTDRTVVVSTAHGLKFTQS 441 >6HUL-B nrPDB Length = 425 Score = 101 bits (251), Expect = 5e-22, Method: Composition-based stats. Identities = 70/354 (19%), Positives = 137/354 (38%), Gaps = 51/354 (14%) Query: 22 SIHL-TPVLTSSILNQ--LTGRNLFFKCELFQKTGSFKIRGALNAVRSLVPDALERKPKA 78 SI TP+ + L + T ++FK E TGS KI A+ + +E Sbjct: 71 SIGRPTPLFRAKRLEEYLKTPARIYFKYEGATPTGSHKINTAIPQAYFAKEEGIE----H 126 Query: 79 VVTHS-SGNHGQALTYAAKLEGIPAYIVVPQTAPDCK---KLAIQAYGASIVYC------ 128 VVT + +G G A+ AA + + + I + + + + K + +Q YGA++ Sbjct: 127 VVTETGAGQWGTAVALAASMYNMKSTIFMVKVSYEQKPMRRSIMQLYGANVYASPTNLTE 186 Query: 129 ------EPSDESRENVAKRVTE------ETEGIMVHPNQEPAVIAGQGTIALEVLNQVP- 175 E + + ++ ++E + E + + V+ Q I E + Q+ Sbjct: 187 YGRKILETNPQHPGSLGIAMSEAIEYALKNEFRYLVGSVLDVVLLHQSVIGQETITQLDL 246 Query: 176 ---LVDALVVPVGGGGMLAGIAITVKALKPSVKVYAAEPSNADDCYQSKLK------GKL 226 D L+ VGGG G K + A + + + K L Sbjct: 247 LGEDADILIGCVGGGSNFGGFTYPFIGNKKGKRYIAVSSAEIPKFSKGEYKYDFPDSAGL 306 Query: 227 MP---------NLYPPETIADGVKSSIGLNTWPII-RDLVDDIFTVTEDEIKCATQLVWE 276 +P + PP A G++ T ++ ++ + + E EI A ++ E Sbjct: 307 LPLVKMITLGKDYVPPPIYAGGLRYHGVAPTLSLLTKEGIVEWREYNEREIFEAAKIFIE 366 Query: 277 RMKLLIEPTAGVGVAAVLSQHFQTVSPEVKNICIV-LSG-GNVDLTSSITWVKQ 328 ++ P + + AV+ + + + + + LSG G +DL++ + +K+ Sbjct: 367 NQGIVPAPESAHAIRAVVDEAIEARKNNERKVIVFNLSGHGLLDLSNYESMMKR 420 >5EY5-B nrPDB Length = 399 Score = 88.2 bits (217), Expect = 5e-18, Method: Composition-based stats. Identities = 72/354 (20%), Positives = 126/354 (35%), Gaps = 47/354 (13%) Query: 19 IRDSIHL-TPVLTSSILNQLTG-RNLFFKCELFQKTGSFKIRGALNAVRSLVPDALERKP 76 +RD + TP+ + L + G ++ K E TG+ KI NA+ + K Sbjct: 43 LRDYVGRPTPLYFAENLTKDLGGAKIYLKREDLNHTGAHKI---NNALGQALLAKRMGKK 99 Query: 77 KAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKL---AIQAYGAS---IVYCEP 130 + + +G HG A A + G+ + + + + L ++ GA + Sbjct: 100 RVIAETGAGQHGVATATVAAMFGLECVVYMGAEDIERQALNVFRMKLLGAKVRPVTSGSR 159 Query: 131 SDESRENVAKR--VTEETEGIMVHPNQ---EPAVI---AGQGTIALE----VLNQVPLV- 177 + + N A R VT + + + P + Q I E +L + + Sbjct: 160 TLKDAINEAMRDWVTNVEDTFYIIGSVVGPHPYPMMVRDFQSVIGEEARQQILEKEGRLP 219 Query: 178 DALVVPVGGGGMLAGIAITVKALKPSVKVYAAEPSNA-----------DDCYQSKLKGKL 226 DA+V VGGG GI SV++ E + L G + Sbjct: 220 DAIVACVGGGSNAMGIFHPF-IDDESVRLIGVEAAGKGIETGKHAATLSAGRPGVLHGAM 278 Query: 227 MPNLYPPET-IADGVKSSIGLNTW---PIIRDLVD----DIFTVTEDEIKCATQLVWERM 278 L + I + S GL+ P L D + +VT+DE A QL+ Sbjct: 279 TYLLQDEDGQIIEAHSISAGLDYPGVGPEHAYLKDTGRAEYVSVTDDEALEAFQLLSRTE 338 Query: 279 KLLIEPTAGVGVAAVLSQHFQTVSPEVKNICIVLSG-GNVDLTSSITWVKQAER 331 ++ P A + + + I + LSG G+ D+ + ++ E Sbjct: 339 GII--PALESSHAVAYAMKLAPELSKDQIIVVNLSGRGDKDVNTVARYLLGVEL 390 >5OCW-B nrPDB Length = 442 Score = 85.2 bits (209), Expect = 4e-17, Method: Composition-based stats. Identities = 65/358 (18%), Positives = 113/358 (31%), Gaps = 50/358 (13%) Query: 9 FADVEKAHINIRDSIHL-TPVLTSSILNQLTG-RNLFFKCELFQKTGSFKIRGALNAVRS 66 D+++ N +P+ ++ L+Q G +F K E TGS KI N + Sbjct: 87 LDDLDRLQAN---YAGRPSPLYEATRLSQHAGSARIFLKREDLNHTGSHKI---NNVLGQ 140 Query: 67 LVPDALERKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVP---QTAPDCKKLAIQAYGA 123 + K + + +G HG A A L G+ I + ++ GA Sbjct: 141 ALLARRMGKTRVIAETGAGQHGVATATACALLGLDCVIYMGGIDTARQALNVARMRLLGA 200 Query: 124 SIVYCEPSDESRENVAKRVTEE-----------TEGIMVHPNQEPAVIAGQGTIALE--- 169 +V + ++ ++ + V Q I +E Sbjct: 201 EVVAVQTGSKTLKDAINEAFRDWVANADNTYYCFGTAAGPHPFPTMVRDFQRIIGMEARV 260 Query: 170 -VLNQVPLV-DALVVPVGGGGMLAGIAITVKALKPSVKVYAAEPSN-------------- 213 + Q + DA+V VGGG GI P V++ E + Sbjct: 261 QIQGQAGRLPDAVVACVGGGSNAIGIFHAF-LDDPGVRLVGFEAAGDGVETGRHAATFTA 319 Query: 214 ----ADDCYQSKLKGKLMPNLYPPETIADGVK-SSIGLNTWPIIRDLVDDIFTVTEDEIK 268 A S L +I+ G+ +G + D +T+ E Sbjct: 320 GSPGAFHGSFSYLLQDEDGQTIESHSISAGLDYPGVGPEHAWLKEAGRVDYRPITDSEAM 379 Query: 269 CATQLVWERMKLLIEPTAGVGVAAVLSQHFQTVSPEVKNICIVLSG-GNVDLTSSITW 325 A L+ ++ + VA L I + LSG G+ D+ ++ W Sbjct: 380 DAFGLLCRMEGIIPAIESAHAVAGALK--LGVELGRGAVIVVNLSGRGDKDVETAAKW 435 >4NEG-A nrPDB Length = 400 Score = 85.2 bits (209), Expect = 4e-17, Method: Composition-based stats. Identities = 67/358 (18%), Positives = 127/358 (35%), Gaps = 47/358 (13%) Query: 13 EKAHINIRDSIHL-TPVLTSSILNQLTG-RNLFFKCELFQKTGSFKIRGALNAVRSLVPD 70 ++ + ++ + TP+ + + + G ++ K E TG+ KI N + + Sbjct: 49 KELNHYLKTYVGRETPLYFAENMTEYCGGAKIYLKREDLNHTGAHKI---NNTIGQALLA 105 Query: 71 ALERKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKL---AIQAYGAS--- 124 K K V +G HG A L G+ I + + +KL ++ GA Sbjct: 106 VRMGKKKVVAETGAGQHGVATATVCALLGLECVIFMGEEDVRRQKLNVFRMELLGAKVES 165 Query: 125 IVYCEPSDESRENVAKR--VTEETEGIMVHPNQ---EPA---VIAGQGTIALEVLNQVPL 176 + + + N A R V+ + + + P V Q I E Q Sbjct: 166 VAAGSGTLKDAVNEALRYWVSHVHDTHYIMGSVLGPHPFPQIVRDFQSVIGNETKKQYEA 225 Query: 177 V-----DALVVPVGGGGMLAGIAITVKALKPSVKVYAAEPSNA----DDCYQSKLKGK-- 225 + +A+V +GGG G+ V +Y E + + + KG Sbjct: 226 LEGKLPEAVVACIGGGSNAMGMFYPF-VHDEEVALYGVEAAGKGVHTEKHAATLTKGSVG 284 Query: 226 --------LMPNLYPPETIADGVKSSIGLNTWPIIRDLVDDI-----FTVTEDEIKCATQ 272 L+ N A + + + L+ DI ++T+DE A Q Sbjct: 285 VLHGSMMYLLQNEEGQIQEAHSISAGLDYPGVGPEHSLLKDIGRVSYHSITDDEALEAFQ 344 Query: 273 LVWERMKLLIEPTAGVGVAAVLSQHFQTVSPEVKNICIVLSG-GNVDLTSSITWVKQA 329 L+ ++ ++ P A + E + + I LSG G+ D+ S ++++ Sbjct: 345 LLTKKEGII--PALESSHAVAYALKLAPQMKEDEGLVICLSGRGDKDVESIKRYMEEV 400 >4D9F-A nrPDB Length = 342 Score = 84.0 bits (206), Expect = 9e-17, Method: Composition-based stats. Identities = 61/322 (18%), Positives = 111/322 (34%), Gaps = 42/322 (13%) Query: 20 RDSIHL-TPVLTSSILNQLTGRNLFFKCELFQK--TGSFKIRGALNAVRSLVPDALERKP 76 + I TP+ L+ GR ++ K + G K+R + LV DAL Sbjct: 26 LEFIGAPTPLEYLPRLSDYLGREIYIKRDDVTPIAMGGNKLR----KLEFLVADALREGA 81 Query: 77 KAVVTHSS--GNHGQALTYAAKLEGIPAYIVV--PQTAPDCK------KLAIQAYGASIV 126 ++T + NH + A G+ ++ P +L + + I Sbjct: 82 DTLITAGAIQSNHVRQTAAVAAKLGLHCVALLENPIGTTAENYLTNGNRLLLDLFNTQIE 141 Query: 127 YCEP---SDESRENVAKRVTEE--TEGIMVHPNQEPAVIAGQGTIALEVLNQVPLV---D 178 C+ D + +A R+ + ++ G ALE+ Q V Sbjct: 142 MCDALTDPDAQLQTLATRIEAQGFRPYVIPVGGSSALGAMGYVESALEIAQQCEEVVGLS 201 Query: 179 ALVVPVGGGGMLAGIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIAD 238 ++VV G G AG+A+ ++ L P V++ + + + Sbjct: 202 SVVVASGSAGTHAGLAVGLEHLMPDVELIGV-----------TVSRSVAEQKPKVIALQQ 250 Query: 239 GVKSSIGLNTWPIIRDLVDDIFT----VTEDEIKCATQLVWERMKLLIEPT-AGVGVAAV 293 + + L I L DD F V D A +L+ +L++P G +A + Sbjct: 251 AIAGQLALTATADI-HLWDDYFAPGYGVPNDAGMEAVKLLASLEGVLLDPVYTGKAMAGL 309 Query: 294 LSQHFQTVSPEVKNICIVLSGG 315 + Q + I + +GG Sbjct: 310 IDGISQKRFNDDGPILFIHTGG 331 >5KIN-B nrPDB Length = 407 Score = 82.1 bits (201), Expect = 3e-16, Method: Composition-based stats. Identities = 78/360 (21%), Positives = 119/360 (33%), Gaps = 52/360 (14%) Query: 3 AQYCISFADVEKAHINIRDSIHL-TPVLTSSILNQLTG-RNLFFKCELFQKTGSFKIRGA 60 +Q SF E+ + +R + TP+ + L Q G ++ K E TG+ KI A Sbjct: 38 SQADPSFQ--EELNQLLRQYVGRETPLYYAKNLTQHIGGAKIYLKREDLNHTGAHKINNA 95 Query: 61 LNAVRSLVPDALERKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQ---TAPDCKKLA 117 L V K K + +G HG A AA L + I + + Sbjct: 96 LGQVWLAKRMG---KKKIIAETGAGQHGVATATAAALFNMECTIYMGEEDVKRQALNVFR 152 Query: 118 IQAYGASIVYCEPSDE---SRENVAKR--VTEETEGIMVHPNQ---EPA---VIAGQGTI 166 ++ GA + N A R V + + + P V Q I Sbjct: 153 MELLGAKVEAVTDGSRVLKDAVNAALRSWVANIDDTHYILGSALGPHPFPEIVRDFQSVI 212 Query: 167 ALEVLNQV------PLVDALVVPVGGGGMLAGIAITVKALKPSVKVYAAEPSNAD----- 215 E Q L DALV VGGG G+ SV +Y E + Sbjct: 213 GREAKQQYRDLTGRDLPDALVACVGGGSNAIGLFHPFVE-DESVAMYGTEAAGLGVDTEH 271 Query: 216 ------DCYQSKLKGKLMPNLYPPET-IADGVKSSIGLNTWPIIRDLVD-------DIFT 261 L G LM L I + S GL+ I + Sbjct: 272 HAATLTKGRPGVLHGSLMDVLQDAHGQILEAFSISAGLDYPGIGPEHSHYHDIKRASYVP 331 Query: 262 VTEDEIKCATQLVWERMKLL--IEPTAGVGVAAVLSQHFQTVSPEVKNICIVLSGGNVDL 319 VT++E QL+ ++ +E + + A L++ + PE I + G+ D+ Sbjct: 332 VTDEEALEGFQLLSRVEGIIPALESSHAIAFAVKLAKE---LGPEKSMIVCLSGRGDKDV 388 >6AMI-A nrPDB Length = 396 Score = 80.5 bits (197), Expect = 9e-16, Method: Composition-based stats. Identities = 59/334 (17%), Positives = 108/334 (32%), Gaps = 46/334 (13%) Query: 26 TPVLTSSILNQLTG-RNLFFKCELFQKTGSFKIRGALNAVRSLVPDALERKPKAVVTHSS 84 TP+ + L + G ++ K E G+ K NA+ + K + + + Sbjct: 51 TPLYYAKRLTEKIGGAKVYLKREDLVHGGAHK---TNNAIGQALLAKFMGKTRLIAETGA 107 Query: 85 GNHGQALTYAAKLEGIPAYIVVPQTAPDCKKL---AIQAYGASIVYCEPSDESRENVAKR 141 G HG A A L G+ I + + +K+ ++ GA+++ + ++ Sbjct: 108 GQHGVATAMAGALLGMKVDIYMGAEDVERQKMNVFRMKLLGANVIPVNSGSRTLKDAINE 167 Query: 142 VTE------ETEGIMVHPNQEPAVI-----AGQGTIALEVLNQVPLV-----DALVVPVG 185 E ++ P Q I E Q+ D +V VG Sbjct: 168 ALRDWVATFEYTHYLIGSVVGPHPYPTIVRDFQSVIGREAKAQILEAEGQLPDVIVACVG 227 Query: 186 GGGMLAGIAITVKALKPSVKVYAAEPSN----ADDCYQSKLKGKLMPN------------ 229 GG GI VK+ E + S G++ + Sbjct: 228 GGSNAMGIFYPF-VNDKKVKLVGVEAGGKGLESGKHSASLNAGQVGVSHGMLSYFLQDEE 286 Query: 230 --LYPPETIADGVK-SSIGLNTWPIIRDLVDDIFTVTEDEIKCATQLVWERMKLLIEPTA 286 + P +IA G+ +G + + + VT++E A + ++ P Sbjct: 287 GQIKPSHSIAPGLDYPGVGPEHAYLKKIQRAEYVAVTDEEALKAFHELSRTEGII--PAL 344 Query: 287 GVGVAAVLSQHFQTVSPEVKNICIVLSG-GNVDL 319 A + + I + LSG G+ DL Sbjct: 345 ESAHAVAYAMKLAKEMSRDEIIIVNLSGRGDKDL 378 >5KZM-B nrPDB Length = 396 Score = 79.4 bits (194), Expect = 2e-15, Method: Composition-based stats. Identities = 59/359 (16%), Positives = 117/359 (32%), Gaps = 51/359 (14%) Query: 3 AQYCISFADVEKAHINIRDSIHL-TPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGAL 61 AQ SF ++ +++ T + + + + T L+ K E G+ K Sbjct: 34 AQADESFK--QEFKELLQEYAGRPTALTKTRNIVKNTRTKLYLKREDLLHGGAHK----T 87 Query: 62 NAVRSLVPDALERKPKAVVTHS-SGNHGQALTYAAKLEGIPAYIVVPQTAPDCK---KLA 117 N V A K ++ + +G HG A A L + + + + + Sbjct: 88 NQVLGQALLAKRMGKKEIIAETGAGQHGVATALACALLDLKCRVYMGAKDVERQSPNVFR 147 Query: 118 IQAYGASIVYCEPSDESRENVAKRVTEETEGIM------------VHPNQEPAVIAGQGT 165 ++ GA ++ + ++ + HP V Q Sbjct: 148 MKLMGAEVIPVHSGSATLKDACNEALRDWSANYSKAHYLLGTAAGPHPF-PTIVREFQRM 206 Query: 166 IALEVLNQV-----PLVDALVVPVGGGGMLAGI-AITVKALKPSVKVYAAEPSNAD---- 215 I E Q+ L DA++ VGGG G+ A + +VK+ EP+ Sbjct: 207 IGEETKQQMLAKEGRLPDAVIACVGGGSNAIGMFADFIDE--KNVKLIGVEPAGKGIETG 264 Query: 216 -------DCYQSKLKGKLMPNLYPPET-IADGVKSSIGLNTWPIIRDLVD-------DIF 260 G P + + I + S GL+ + Sbjct: 265 EHGAPLKHGKTGIFFGMKAPLMQNSDGQIEESYSISAGLDFPSVGPQHAHLLAIGRAKYA 324 Query: 261 TVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQTVSPEVKNICIVLSGGNVDL 319 + T+DE A +L+ ++ ++ + +A L ++ + E + + G+ D+ Sbjct: 325 SATDDEALDAFKLLCKKEGIIPALESSHALAHALKLAYEDPNKEQLLVVNLSGRGDKDI 383 >1X1Q-A nrPDB Length = 418 Score = 79.4 bits (194), Expect = 2e-15, Method: Composition-based stats. Identities = 67/355 (18%), Positives = 125/355 (35%), Gaps = 55/355 (15%) Query: 12 VEKAHINIRDSIHL-TPVLTSSILNQL-TGRNLFFKCELFQKTGSFKIRGALNAVRSLVP 69 +E+ +R TP+ + L++ G +F K E TG+ KI N + + Sbjct: 63 LEELDHYLRQFAGRPTPLYHAKRLSEYWGGAQVFLKREDLLHTGAHKI---NNTLGQALL 119 Query: 70 DALERKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAP---DCKKLAIQAYGAS-- 124 K + + +G HG ++ A L G+ + + + ++ GA Sbjct: 120 ARRMGKRRVIAETGAGQHGVSVATVAALFGLECVVYMGEEDVRRQALNVFRMKLLGAEVR 179 Query: 125 -IVYCEPSDESRENVAKR--VTEETEGIMVHPNQ---EPAVI---AGQGTIALEVLNQVP 175 + + + N A R +T + + P + Q I EV Q Sbjct: 180 PVAAGSRTLKDATNEAIRDWITNVRTTFYILGSVVGPHPYPMMVRDFQSVIGEEVKRQSL 239 Query: 176 LV-----DALVVPVGGGGMLAGI---AITVKALKPSVKVYAAEPSNA-----------DD 216 + DAL+ VGGG G+ + +P K+ E + Sbjct: 240 ELFGRLPDALIAAVGGGSNAIGLFAPFAYLPEGRP--KLIGVEAAGEGLSTGRHAASIGA 297 Query: 217 CYQSKLKGKLMPNLY-------PPETIADGVK-SSIGLNTWPIIRDLVDDIFTVTEDEIK 268 + L G M LY P +++ G+ +G V + +VT++E Sbjct: 298 GKRGVLHGSYMYLLYDHDGQITPAHSVSAGLDYPGVGPEHSYYADAGVAEYASVTDEEAL 357 Query: 269 CATQLVWERMKLL--IEPTAGVGVAAVLSQHFQTVSPEVKNICIVLSG-GNVDLT 320 +L+ ++ +E + AA + + + + I LSG G+ D+T Sbjct: 358 EGFKLLARLEGIIPALESAHAIAYAAKVVPEMD----KDQVVVINLSGRGDKDVT 408 >3SS9-X nrPDB Length = 442 Score = 77.1 bits (188), Expect = 9e-15, Method: Composition-based stats. Identities = 52/298 (17%), Positives = 100/298 (33%), Gaps = 40/298 (13%) Query: 35 NQLTGRNLFFKCELFQK-TGSFKIRGALN-AVRSLVPDALERK----------------- 75 Q L K + +GS K RG + + ALE Sbjct: 96 QQPISGQLLLKKDSHLPISGSIKARGGIYEVLAHAEKLALEAGLLTLDDDYSKLLSPEFK 155 Query: 76 ----PKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYCEPS 131 ++ S+GN G ++ + G + + A KK ++++G ++V E Sbjct: 156 QFFSQYSIAVGSTGNLGLSIGIMSARIGFKVTVHMSADARAWKKAKLRSHGVTVVEYEQD 215 Query: 132 DESRENVAKRVTEETEGIMVHPNQEPAVI-AGQGTIALEVLNQVPL----VDA-----LV 181 ++ + ++ + G + Q VDA + Sbjct: 216 YGVAVEEGRKAAQSDPNCFFIDDENSRTLFLGYSVAGQRLKAQFAQQGRIVDADNPLFVY 275 Query: 182 VPVGGGGMLAGIAITVK-ALKPSVKVYAAEPSNADDCYQSKLKG-----KLMPNLYPPET 235 +P G GG G+A +K A V + AEP+++ G + T Sbjct: 276 LPCGVGGGPGGVAFGLKLAFGDHVHCFFAEPTHSPCMLLGVHTGLHDQISVQDIGIDNLT 335 Query: 236 IADGVKSSIGLNTWPIIRD-LVDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAA 292 ADG+ + L+D +T+++ + + + + +EP+A G+A Sbjct: 336 AADGLAVGRASGFVGRAMERLLDGFYTLSDQTMYDMLGWLAQEEGIRLEPSALAGMAG 393 >1CX9-B nrPDB Length = 397 Score = 76.7 bits (187), Expect = 1e-14, Method: Composition-based stats. Identities = 61/360 (16%), Positives = 118/360 (32%), Gaps = 55/360 (15%) Query: 2 CAQYCISFADVEKAHINIRDSIHL-TPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGA 60 ++ FAD+ K + T + + T L+ K E G+ K Sbjct: 38 DPEFQAQFADLLKNY------AGRPTALTKCQNITAGTRTTLYLKREDLLHGGAHK---- 87 Query: 61 LNAVRSLVPDALERKPKAVVTHS-SGNHGQALTYAAKLEGIPAYIVVPQTAPDCK---KL 116 N V A ++ + +G HG A A+ L G+ I + + + Sbjct: 88 TNQVLGQALLAKRMGKSEIIAETGAGQHGVASALASALLGLKCRIYMGAKDVERQSPNVF 147 Query: 117 AIQAYGASIVYCEPSDESRENVAKRVTEETEGIMVHPNQ--------EPA--------VI 160 ++ GA ++ + ++ + G + P + Sbjct: 148 RMRLMGAEVIPVHSGSATLKDACNEALRDWSGSYETAHYMLGTAAGPHPYPTIVREFQRM 207 Query: 161 AGQGTIALEVLNQVPLVDALVVPVGGGGMLAGI-AITVKALKPSVKVYAAEP-------- 211 G+ T A + + L DA++ VGGG G+ A + SV + EP Sbjct: 208 IGEETKAQILDKEGRLPDAVIACVGGGSNAIGMFADFINDT--SVGLIGVEPGGHGIETG 265 Query: 212 -SNADDCYQ--SKLKGKLMPNLYPPET-IADGVKSSIGLNTWPIIRDLV-------DDIF 260 A + G P + + I + S GL+ + D Sbjct: 266 EHGAPLKHGRVGIYFGMKAPMMQTADGQIEESYSISAGLDFPSVGPQHAYLNSIGRADYV 325 Query: 261 TVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQTVSPEVKNICIVLSG-GNVDL 319 ++T+DE A + + ++ + +A L + + + + + LSG G+ D+ Sbjct: 326 SITDDEALEAFKTLCRHEGIIPALESSHALAHALK-MMREQPEKEQLLVVNLSGRGDKDI 384 >3R0X-A nrPDB Length = 448 Score = 73.6 bits (179), Expect = 1e-13, Method: Composition-based stats. Identities = 51/326 (15%), Positives = 102/326 (31%), Gaps = 49/326 (15%) Query: 6 CISFADVEKAHINIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALN-AV 64 + + T + G L K +GS K RG + + Sbjct: 76 ESDVVAIPAMQKRLEKEYGQT----------INGEMLLKKDSHLAISGSIKARGGIYEVL 125 Query: 65 RSLVPDALERK---------------------PKAVVTHSSGNHGQALTYAAKLEGIPAY 103 ALE ++ S+GN G ++ + G Sbjct: 126 THAEKLALEAGLLTTDDDYSVLLSPEFKQFFSQYSIAVGSTGNLGLSIGIMSACIGFKVT 185 Query: 104 IVVPQTAPDCKKLAIQAYGASIVYCEPSDESRENVAKRVTEETEGIMVHPNQEPAVI-AG 162 + + A KK ++++G ++V E ++ + ++ + G Sbjct: 186 VHMSADARAWKKAKLRSHGVTVVEYEDDYGVAVEQGRKAAQSDPNCFFIDDENSRTLFLG 245 Query: 163 QGTIALEVLNQVPLVDALV---------VPVGGGGMLAGIAITVK-ALKPSVKVYAAEPS 212 + Q +V +P G GG G+A +K A +V + AEP+ Sbjct: 246 YAVAGQRLKAQFAQQGRVVDASHPLFVYLPCGVGGGPGGVAFGLKLAFGDNVHCFFAEPT 305 Query: 213 NADDCYQSKLKG-----KLMPNLYPPETIADGVKSSIGLNTWPIIRD-LVDDIFTVTEDE 266 ++ G + T ADG+ + L+D ++T+ + Sbjct: 306 HSPCMLLGVYTGLHDAISVQDIGIDNLTAADGLAVGRASGFVGRAMERLLDGLYTLDDQT 365 Query: 267 IKCATQLVWERMKLLIEPTAGVGVAA 292 + + + + +EP+A G+A Sbjct: 366 MYDMLGWLAQEEGIRLEPSALAGMAG 391 >1J0B-A nrPDB Length = 325 Score = 72.1 bits (175), Expect = 3e-13, Method: Composition-based stats. Identities = 52/305 (17%), Positives = 105/305 (34%), Gaps = 31/305 (10%) Query: 26 TPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVRSLVP---DALERKPKAVVTH 82 TP+ +++ G +++ K + G N +R L DAL + V+T Sbjct: 22 TPIQYLPNISREIGADVYIKRDDLTGLG-----IGGNKIRKLEYLLGDALSKGADVVITV 76 Query: 83 SS--GNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAI-QAYGASIVYCEPSDES----- 134 + NH AAK G+ A +V+ + + G + D Sbjct: 77 GAVHSNHAFVTGLAAKKLGLDAILVLRGKEELKGNYLLDKIMGIETRVYDAKDSFELMKY 136 Query: 135 RENVAKRVTEE--TEGIMVHPNQEPAVIAGQGTIALEVLNQVP-LVDALVVPVGGGGMLA 191 E +A+ + E ++ P G E+ Q D++VV G GG LA Sbjct: 137 AEEIAEELKREGRKPYVIPPGGASPIGTLGYVRAVGEIATQSEVKFDSIVVAAGSGGTLA 196 Query: 192 GIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGVKSSIGLNTWPI 251 G+++ + L ++ + SKL L+ + V+ + ++ Sbjct: 197 GLSLGLSILNEDIRPVGIAVGRFGEVMTSKLDN-LIKEAAELLGVKVEVRPELYDYSFGE 255 Query: 252 IRDLVDDIFTVTEDEIKCATQLVWERMKLLIEPT-AGVGVAAVLSQHFQTVSPEVKNICI 310 + ++ + + V R ++++P G ++ + I Sbjct: 256 YGKITGEVAQI--------IRKVGTREGIILDPVYTGKAFYGLVD--LARKGELGEKILF 305 Query: 311 VLSGG 315 + +GG Sbjct: 306 IHTGG 310 >1RQX-A nrPDB Length = 338 Score = 67.4 bits (163), Expect = 8e-12, Method: Composition-based stats. Identities = 50/322 (15%), Positives = 97/322 (30%), Gaps = 37/322 (11%) Query: 22 SIHLTPVLTSSILNQLTG--RNLFFKCELFQKTGSF---KIRGALNAVRSLVPDALERKP 76 + TP+ + L++ G +L+ K E +F K R + L+P+AL + Sbjct: 12 TFGPTPIQPLARLSKHLGGKVHLYAKREDCNSGLAFGGNKTR----KLEYLIPEALAQGC 67 Query: 77 KAVVT--HSSGNHGQALTYAAKLEGIPAYIVVPQTAPDC--------KKLAIQAYGASIV 126 +V+ N + + A G+ +V + GA + Sbjct: 68 DTLVSIGGIQSNQTRQVAAVAAHLGMKCVLVQENWVNYSDAVYDRVGNIQMSRILGADVR 127 Query: 127 YCEP--------SDESRENVAKRVTEETEGIMVHPNQEPAVIAGQGTIALEVLNQVPLV- 177 S E + + I + P G A EV Q + Sbjct: 128 LVPDGFDIGFRRSWEDALESVRAAGGKPYAIPAGCSDHPLGGLGFVGFAEEVRAQEAELG 187 Query: 178 ---DALVVPVGGGGMLAGIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPE 234 D +VV G AG+ + A + +V + S + + + + Sbjct: 188 FKFDYVVVCSVTGSTQAGMVVGFAADGRADRVIGVDASA-----KPAQTREQITRIARQT 242 Query: 235 TIADGVKSSIGLNTWPIIRDLVDDIFTVTEDEIKCATQLVWERMKLLIEPT-AGVGVAAV 293 G++ I + + + + A +L +L +P G + + Sbjct: 243 AEKVGLERDIMRADVVLDERFAGPEYGLPNEGTLEAIRLCARTEGMLTDPVYEGKSMHGM 302 Query: 294 LSQHFQTVSPEVKNICIVLSGG 315 + PE + GG Sbjct: 303 IEMVRNGEFPEGSRVLYAHLGG 324 >6EQN-B nrPDB Length = 425 Score = 62.4 bits (150), Expect = 3e-10, Method: Composition-based stats. Identities = 69/352 (19%), Positives = 127/352 (36%), Gaps = 55/352 (15%) Query: 26 TPVLTSSILNQLTGRNL--FFKCELFQKTGSFKIRGALNAVRSLVPDALERKPKAVVTHS 83 TP++ + L + G N+ + K E + TGS KI AL V A K V T + Sbjct: 76 TPIIRAKRLEEYLGNNIKIYLKMESYTYTGSHKINSALAHV----YYAKLDNAKFVTTET 131 Query: 84 -SGNHGQALTYAAKLEGIPAYIVVPQT---APDCKKLAIQAYGASI-------------- 125 +G G ++ A+ L + A+I + +T A +K +Q YGA + Sbjct: 132 GAGQWGSSVALASALFRMKAHIFMVRTSYYAKPYRKYMMQMYGAEVHPSPSDLTEFGRQL 191 Query: 126 ----VYCEPSDESRENVAKRVTEETEGIMVHPNQEPAVIAGQGTIALEVLNQVPLV---- 177 S + A + G V + + I + +E Q+ L+ Sbjct: 192 LAKDSNHPGSLGIAISDAVEYAHKNGGKYVVGSVVNSDIMFKTIAGMEAKKQMELIGEDP 251 Query: 178 DALVVPVGGGGMLAGIAI-----TVKALKPSVKVYAAEPSNADDCYQSKLK------GKL 226 D ++ VGGG A +A +++ K K A+ S + K KL Sbjct: 252 DYIIGVVGGGSNYAALAYPFLGDELRSGKVRRKYIASGSSEVPKMTKGVYKYDYPDTAKL 311 Query: 227 MP---------NLYPPETIADGVKSSIGLNTWP-IIRDLVDDIFTVTEDEIKCATQLVWE 276 +P + PP A G++ T +I + +++E +L E Sbjct: 312 LPMLKMYTIGSDFVPPPVYAGGLRYHGVAPTLSLLISKGIVQARDYSQEESFKWAKLFSE 371 Query: 277 RMKLLIEP--TAGVGVAAVLSQHFQTVSPEVKNICIVLSGGNVDLTSSITWV 326 + P + + + A +++ + + G +DL + + + Sbjct: 372 LEGYIPAPETSHALPILAEIAEEAKKSGERKTVLVSFSGHGLLDLGNYASVL 423 >1VB3-A nrPDB Length = 428 Score = 59.0 bits (141), Expect = 3e-09, Method: Composition-based stats. Identities = 49/268 (18%), Positives = 94/268 (35%), Gaps = 27/268 (10%) Query: 51 KTGSFKIRGALNAVRSLVPDALERKPKAVVTHSSGNHGQALTYAAKLE-GIPAYIVVPQT 109 T +FK G + ++ KP ++T +SG+ G A+ +A + I+ P+ Sbjct: 102 PTLAFKDFGG-RFMAQMLTHIAGDKPVTILTATSGDTGAAVAHAFYGLPNVKVVILYPRG 160 Query: 110 A-PDCKKLAIQAYGASI--VYCEPSDESRENVAKRV--TEETEGIMVHPNQEPAVIAG-- 162 ++ G +I V + ++ + + K+ EE + + + I+ Sbjct: 161 KISPLQEKLFCTLGGNIETVAIDGDFDACQALVKQAFDDEELKVALGLNSANSINISRLL 220 Query: 163 -QGTIALEVLNQVPLVD----ALVVPVGGGGMLAGIAITVKALKPSVKVYAAEPSNADDC 217 Q E + Q+P + VP G G L + K+L VK + A + D Sbjct: 221 AQICYYFEAVAQLPQETRNQLVVSVPSGNFGDLTA-GLLAKSLGLPVKRFIAATNVNDTV 279 Query: 218 YQSKLKGKLMPNLYPPETIADGVKSSIGLNTWPIIRDLVDDIF---------TVTEDEIK 268 + G+ P S WP + +L V ++ + Sbjct: 280 PRFLHDGQWSPKATQATLSNAMDVSQPNN--WPRVEELFRRKIWQLKELGYAAVDDETTQ 337 Query: 269 CATQLVWERMKLLIEPTAGVGVAAVLSQ 296 + + + + EP A V A+ Q Sbjct: 338 QTMREL-KELGYTSEPHAAVAYRALRDQ 364 >3V7N-A nrPDB Length = 487 Score = 39.3 bits (90), Expect = 0.002, Method: Composition-based stats. Identities = 26/144 (18%), Positives = 60/144 (41%), Gaps = 13/144 (9%) Query: 10 ADVEKAHINIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQ-KTGSFKIRGALNAVRSLV 68 ADV + ++ +TP+ + L G + EL T +FK A+ + +L Sbjct: 87 ADVYRHARRGGNAADITPL---TTLGTENGAPVSL-LELSNGPTLAFKD-MAMQLLGNLF 141 Query: 69 PDALERKPKA--VVTHSSGNHGQALTYAAK-LEGIPAYIVVP-QTAPDCKKLAIQAYGAS 124 L + + ++ +SG+ G A YA + EG+ +++ P + + + + Sbjct: 142 EYTLAKHGETLNILGATSGDTGSAAEYAMRGKEGVRVFMLSPHKKMSAFQTAQMYSLQDP 201 Query: 125 IVY---CEPSDESRENVAKRVTEE 145 ++ + +++ K V+ + Sbjct: 202 NIFNLAVNGVFDDCQDIVKAVSND 225 >1KL7-A nrPDB Length = 514 Score = 34.3 bits (77), Expect = 0.068, Method: Composition-based stats. Identities = 47/286 (16%), Positives = 95/286 (33%), Gaps = 32/286 (11%) Query: 6 CISFADVEKAHINIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQ-KTGSFKIRGALNAV 64 D+ K + S +TP++ + ++ NL ELF T +FK AL V Sbjct: 77 DADLKDLIKRSYSTFRSDEVTPLVQNVTGDKE---NLHI-LELFHGPTYAFKD-VALQFV 131 Query: 65 RSLVPDAL----------ERKPKAVVTHSSGNHGQALTYAAK-LEGIPAYIVVPQTAP-- 111 +L L E+K VV +SG+ G A Y + + + +I+ P Sbjct: 132 GNLFEYFLQRTNANLPEGEKKQITVVGATSGDTGSAAIYGLRGKKDVSVFILYPTGRISP 191 Query: 112 --DCKKLAIQAYGASIVYCEPSDESRENVAKRV------TEETEGIMVHPNQEPAVIAGQ 163 + + + + + ++ +++ K + + V+ ++A Sbjct: 192 IQEEQMTTVPDENVQTLSVTGTFDNCQDIVKAIFGDKEFNSKHNVGAVNSINWARILAQM 251 Query: 164 GTIALEVLNQVPLVDA----LVVPVGGGGMLAGIAITVKALKPSVKVYAAEPSNADDCYQ 219 D+ VVP G G + K + ++ A + D + Sbjct: 252 TYYFYSFFQATNGKDSKKVKFVVPSGNFGDILA-GYFAKKMGLPIEKLAIATNENDILDR 310 Query: 220 SKLKGKLMPNLYPPETIADGVKSSIGLNTWPIIRDLVDDIFTVTED 265 G + T++ + I N ++ L + +D Sbjct: 311 FLKSGLYERSDKVAATLSPAMDILISSNFERLLWYLAREYLANGDD 356 >2VCY-A nrPDB Length = 344 Score = 33.9 bits (76), Expect = 0.093, Method: Composition-based stats. Identities = 25/141 (17%), Positives = 43/141 (30%), Gaps = 21/141 (14%) Query: 60 ALNAVRSLVPDALERKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCK-KLAI 118 A + L+ + S+ GQA+ A G+ VV K + Sbjct: 142 AYRMLMDFEQ--LQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRL 199 Query: 119 QAYGASIVYCEPSDESRENVAKRVTEETEGIMVHPNQEPAVIAGQGTIALEVLNQVPLVD 178 ++ GA V E E + + + M P + G+ + E+L Q+ Sbjct: 200 KSLGAEHVITE------EELRRPEMKNFFKDMPQPRLALNCVGGKSST--ELLRQLAR-- 249 Query: 179 ALVVPVGGGGMLAGIAITVKA 199 GG + K Sbjct: 250 --------GGTMVTYGGMAKQ 262 >3IP1-A nrPDB Length = 404 Score = 32.0 bits (71), Expect = 0.38, Method: Composition-based stats. Identities = 39/220 (17%), Positives = 65/220 (29%), Gaps = 39/220 (17%) Query: 39 GRNLFFKCELFQKTGSFKIRGALNAVRSLVPDALERKPKAVVTHSSGNHGQALTYAAKLE 98 G LF L + T A NAV +V R VV G L A L+ Sbjct: 184 GDRLFLAGSLVEPTS-----VAYNAV--IVRGGGIRPGDNVVILGGG--PIGLAAVAILK 234 Query: 99 GIPAYIVVPQTAPDCKKLAIQAYGASIVYCEPSDESRENV--------AKRVTEETEGIM 150 A V+ + ++ + GA V + E V AK E T Sbjct: 235 HAGASKVILSEPSEVRRNLAKELGADHVIDPTKENFVEAVLDYTNGLGAKLFLEATG--- 291 Query: 151 VHPNQEPAVIAGQGTIALEVLNQVPLVDALVVPVGGG-GMLAGIAITVKALKPSVKVYAA 209 V P + EV+ + ++A V V + + + ++ + Sbjct: 292 VPQLVWPQI--------EEVIWRARGINATVAIVARADAKIPLTGEVFQVRR--AQIVGS 341 Query: 210 EPSNADD--------CYQSKLKGKLMPNLYPPETIADGVK 241 + + K++ E I + +K Sbjct: 342 QGHSGHGTFPRVISLMASGMDMTKIISKTVSMEEIPEYIK 381 >1T8T-A nrPDB Length = 271 Score = 31.6 bits (70), Expect = 0.44, Method: Composition-based stats. Identities = 27/106 (25%), Positives = 47/106 (44%), Gaps = 11/106 (10%) Query: 164 GTIAL---EVLNQVPLVDALVVPVGGGGMLAGIAITVKALKPSVKVYAAEPSNADDCYQS 220 GT+AL E Q+P A+++ V GG A + ++ + P V+ AEP +S Sbjct: 4 GTLALLLDEGSKQLPQ--AIIIGVKKGGTRALL-EFLR-VHPDVRAVGAEPH---FFDRS 56 Query: 221 KLKGKLMPNLYPPETIADGVKSSIGLNTWPIIRDLVDDIFTVTEDE 266 KG P T+ DG + ++ + R+ I +++D Sbjct: 57 YDKGLAWYRDLMPRTL-DGQITMEKTPSYFVTREAPARISAMSKDT 101 >5ZLR-A nrPDB Length = 380 Score = 31.2 bits (69), Expect = 0.68, Method: Composition-based stats. Identities = 19/76 (25%), Positives = 31/76 (40%), Gaps = 2/76 (2%) Query: 165 TIALEVLNQVPLVDALVVPVGGGGMLAGIAITVKALKPSVKVYAAEPSNADDCYQSKLKG 224 T ++E+L A+V +G G L G A +K ++P V V + A Q+ L Sbjct: 60 TESVEMLLSSDTSSAVVKSMGVG--LLGFADALKRMQPDVLVVLGDRFEALAVTQAALIM 117 Query: 225 KLMPNLYPPETIADGV 240 + I +G Sbjct: 118 HVPVAHLHGGEITEGA 133 >2H6E-A nrPDB Length = 344 Score = 31.2 bits (69), Expect = 0.69, Method: Composition-based stats. Identities = 23/133 (17%), Positives = 48/133 (36%), Gaps = 14/133 (10%) Query: 155 QEPAVIAGQGTIALEVLNQ-VPLVDALVVPV----GGGGMLAGIAITVKALKPSVKVYAA 209 E A +A GT ++ + Q +P + PV G GG+ +KAL ++ + Sbjct: 143 VEAAPLADAGTTSMGAIRQALPFISKFAEPVVIVNGIGGLAVYTIQILKALMKNITIVGI 202 Query: 210 EPSNADDCYQSKLKGKLMPNLYPPETIADGVKSSIGLNTWPIIRDLVDDIFTVTEDEIKC 269 S + +L + + E++ + + +G + I V +E Sbjct: 203 SRSKKHRDFALELGADYVSEMKDAESLINKLTDGLGASI---------AIDLVGTEETTY 253 Query: 270 ATQLVWERMKLLI 282 + + +I Sbjct: 254 NLGKLLAQEGAII 266 >3OM8-A nrPDB Length = 266 Score = 31.2 bits (69), Expect = 0.74, Method: Composition-based stats. Identities = 28/186 (15%), Positives = 63/186 (33%), Gaps = 16/186 (8%) Query: 130 PSDESRENVAKRVTEETEGIMVHPNQEPAVIAGQGTIALEVLNQVPLVDALVVPVGGGGM 189 P+ V + V P P +A G LE+L+ + + A + + GG Sbjct: 48 PALTRHFRVLRYDARGHGASSVPP--GPYTLARLGEDVLELLDALEVRRAHFLGLSLGG- 104 Query: 190 LAGIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGVKSSIGLNTW 249 + G + + A + ++ A + + + + + E +++ +G Sbjct: 105 IVGQWLALHAPQRIERLVLANT--SAWLGPAAQWDERIAAVLQAEDMSETAAGFLGNWFP 162 Query: 250 PIIRDLVDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQTVSPEVKNIC 309 P + + + + E A + R L AAV + ++ Sbjct: 163 PALLERAEPVV-----ERFRAMLMATNRHGL------AGSFAAVRDTDLRAQLARIERPT 211 Query: 310 IVLSGG 315 +V++G Sbjct: 212 LVIAGA 217 >3NXS-A nrPDB Length = 329 Score = 30.8 bits (68), Expect = 0.78, Method: Composition-based stats. Identities = 20/117 (17%), Positives = 35/117 (29%), Gaps = 12/117 (10%) Query: 176 LVDALVVPVGGGGMLAGIAITVKAL-----KPSVKVYAAEPSN---ADDCYQSKLKGKLM 227 DA + P G L G+A + V E ++ + + Sbjct: 117 HPDAYIRPSPTSGTLGGVAKATRETIVLLEAAGYDVILVETVGVGQSEVTVAGMVDTFVF 176 Query: 228 PNLYPPETIADGVKSSIGLNTWPIIRDLVDDIFTVTED----EIKCATQLVWERMKL 280 L G+K + I+ + D V E+ A +L++ R L Sbjct: 177 LTLARTGDQLQGIKKGVLELADVIVVNKADGEHAVEAKAAARELSGAIRLIYPRESL 233 >5W8S-A nrPDB Length = 382 Score = 30.5 bits (67), Expect = 1.2, Method: Composition-based stats. Identities = 19/92 (20%), Positives = 30/92 (32%), Gaps = 3/92 (3%) Query: 172 NQVPLVDALVVPVGGGG-MLAGIAITVKALKPSVKVYAAEPS--NADDCYQSKLKGKLMP 228 Q PL ALV G + AG+ +K P+ + A+ C +L Sbjct: 3 EQRPLTIALVAGETSGDILGAGLIRALKEHVPNARFVGVAGPRMQAEGCEAWYEMEELAV 62 Query: 229 NLYPPETIADGVKSSIGLNTWPIIRDLVDDIF 260 + S I + +L D+F Sbjct: 63 MGISESSGRSRRSSHIRADLTKRFGELKPDVF 94 >3E7W-A nrPDB Length = 511 Score = 30.1 bits (66), Expect = 1.3, Method: Composition-based stats. Identities = 18/99 (18%), Positives = 28/99 (28%), Gaps = 14/99 (14%) Query: 152 HPNQEPAVIAGQGTIALEVLNQVPLVDALVVPVGGGGMLAGIAITVKALKPSVKVYA-AE 210 +P + GQ E+ Q A + ++G K + VY E Sbjct: 14 YPQTDAFRSQGQSLTYQELWEQSDRAAAAIQK-----RISG------EKKSPILVYGHME 62 Query: 211 PSNADDCYQSKLKGK--LMPNLYPPETIADGVKSSIGLN 247 P S G + +L P + S G Sbjct: 63 PHMIVSFLGSVKAGHPYIPVDLSIPSERIAKIIESSGAE 101 >1WCV-1 nrPDB Length = 257 Score = 30.1 bits (66), Expect = 1.3, Method: Composition-based stats. Identities = 17/97 (17%), Positives = 27/97 (27%), Gaps = 2/97 (2%) Query: 183 PVGGGGMLAGIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGVKS 242 VG +A + L V + +P + + +L E + V Sbjct: 17 GVGKTTTAINLAAYLARLGKRVLLVDLDPQGNATSGLGVRAERGVYHLLQGEPLEGLVHP 76 Query: 243 SIGLNTWPIIRDLVDDIFTVTEDEIKCATQLVWERMK 279 G + P DLV TV A + Sbjct: 77 VDGFHLLPATPDLVGA--TVELAGAPTALREALRDEG 111 >4G5X-A nrPDB Length = 279 Score = 29.7 bits (65), Expect = 1.7, Method: Composition-based stats. Identities = 31/183 (16%), Positives = 64/183 (34%), Gaps = 32/183 (17%) Query: 119 QAYGASIVYCEPSDESRENVAKRVTEETE--GIMVHPN-------------QEPAVIAGQ 163 + GA ++ + S A ++ E ++ P+ + G Sbjct: 21 EGEGAPLLMIHGNSSSGAIFAPQLEGEIGKKWRVIAPDLPGHGKSTDAIDPDRSYSMEGY 80 Query: 164 GTIALEVLNQVPLVDALVVPVGGGGMLAGIAITVKALKPSVK---VYAAEPSNADDCYQS 220 EV+ Q+ + DA+V GG + I + A P ++ + P ++ Q Sbjct: 81 ADAMTEVMQQLGIADAVVFGWSLGGHI---GIEMIARYPEMRGLMITGTPPVAREEVGQG 137 Query: 221 KLKGKLM----PNLYPPETIADGVKSSIGLNTWPIIRDLVDDIFTVTEDEIKCATQLVWE 276 G M ++ + +S+ G P L+D I T+ A ++++E Sbjct: 138 FKSGPDMALAGQEIFSERDVESYARSTCGE---PFEASLLD-IVARTDGR---ARRIMFE 190 Query: 277 RMK 279 + Sbjct: 191 KFG 193 >6HLX-A nrPDB Length = 492 Score = 29.7 bits (65), Expect = 1.7, Method: Composition-based stats. Identities = 15/103 (14%), Positives = 33/103 (32%), Gaps = 9/103 (8%) Query: 86 NHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYCEPSDESRENVA------ 139 N A+ GI + +P A K + Y +++ + ++ Sbjct: 337 NTAIAIQSELAKIGIKVKLDLPDWASRMAKASTGDYDFTVMGSLGEITDADWLSNYYYGG 396 Query: 140 KRVTEETEGIMVHPNQ-EPAVIAGQGTIALEVLNQVPLVDALV 181 ++ + Q + G+ T+ +V + DA V Sbjct: 397 DKLVRTNNSPYFNDQQINDLLDKGRATVDK--AERVKIYDAFV 437 >1SEZ-A nrPDB Length = 504 Score = 29.7 bits (65), Expect = 1.8, Method: Composition-based stats. Identities = 13/64 (20%), Positives = 23/64 (35%), Gaps = 2/64 (3%) Query: 181 VVPVGGGGMLAGIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGV 240 V+ G G+ A A +K +V V+ AE G + T ++G Sbjct: 18 VIGAGVSGLAA--AYKLKIHGLNVTVFEAEGKAGGKLRSVSQDGLIWDEGANTMTESEGD 75 Query: 241 KSSI 244 + + Sbjct: 76 VTFL 79 >4WW4-B nrPDB Length = 513 Score = 29.7 bits (65), Expect = 1.8, Method: Composition-based stats. Identities = 9/44 (20%), Positives = 15/44 (34%), Gaps = 2/44 (4%) Query: 53 GSFKIRGALNAVRSLVPDALERKPKAVVT--HSSGNHGQALTYA 94 G K R A V ++ ++ S+G A+ A Sbjct: 73 GQEKARKAAAVVLEMIKQGKIAGRAVLIAGPPSTGKTAIAMGMA 116 >5OC1-A nrPDB Length = 565 Score = 29.3 bits (64), Expect = 2.3, Method: Composition-based stats. Identities = 15/57 (26%), Positives = 21/57 (36%), Gaps = 3/57 (5%) Query: 176 LVDALVVPVGGGGMLAGIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYP 232 D +VV G G + +A + P V V E +D+ L P L P Sbjct: 1 DFDYVVVGAGNAGNV--VAARLTE-DPDVSVLVLEAGVSDENVLGAEAPLLAPGLVP 54 >3GDF-A nrPDB Length = 267 Score = 29.3 bits (64), Expect = 2.5, Method: Composition-based stats. Identities = 16/117 (13%), Positives = 34/117 (29%), Gaps = 7/117 (5%) Query: 97 LEGIPAYIVV------PQTAPDCKKLAIQAYGASIVYCEPS-DESRENVAKRVTEETEGI 149 + +VV P+ GA++ S + E K + + Sbjct: 15 QLSLKGKVVVVTGASGPKGMGIEAARGCAEMGAAVAITYASRAQGAEENVKELEKTYGIK 74 Query: 150 MVHPNQEPAVIAGQGTIALEVLNQVPLVDALVVPVGGGGMLAGIAITVKALKPSVKV 206 + + +V+ +DA + G + +V+A V+V Sbjct: 75 AKAYKCQVDSYESCEKLVKDVVADFGQIDAFIANAGATADSGILDGSVEAWNHVVQV 131 >4W8I-A nrPDB Length = 551 Score = 28.9 bits (63), Expect = 2.9, Method: Composition-based stats. Identities = 46/237 (19%), Positives = 80/237 (33%), Gaps = 48/237 (20%) Query: 74 RKPKAVVTHSSGNHGQALTYAAKLEGIPAY------IVVPQTAPDCKKLAIQAYGASIVY 127 ++ ++TH G AA + A IVVP+TA K A + GA ++ Sbjct: 156 KEGYGLLTH-GGTTSIIEAMAAYVIRARAKGIDYPEIVVPETAHAAFKKAAELTGAILIT 214 Query: 128 CEPSDESRENVAKRVTEETEGIMVHPNQEPAVIAGQGT--IALEVLNQVPLVDALVVPVG 185 V ++T + P V++ T A+ V + ++ + P+ Sbjct: 215 VP------------VDKKTGAV------NPNVMSSYITRNTAVMVGSAPSFMNGIHDPIS 256 Query: 186 GGGMLAGIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGVKSSIG 245 G LA K +V P + D C L L + P + GV S Sbjct: 257 ELGQLA--------KKKNV------PFHVDACLGGFLTAFLDTSSEPMDFRVPGVTSISA 302 Query: 246 LNT----WPIIRDLV---DDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLS 295 P + +D ++ + ++ +L T+G VA V + Sbjct: 303 DLHKYGCCPKGTSVCLFSEDSPALSVYAALNWSGGLYATPGILDGSTSGARVAEVYA 359 >4TLZ-A nrPDB Length = 443 Score = 28.9 bits (63), Expect = 3.0, Method: Composition-based stats. Identities = 18/98 (18%), Positives = 34/98 (34%), Gaps = 3/98 (3%) Query: 181 VVPVGGGGMLAGIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGV 240 V GGG A I + +P V+A PS + + + + DG Sbjct: 220 VAVAGGGQSAAEIVRFLHDNRPDTVVHAIMPSYGYVVADNTPFANQIFDPAAVDDYFDGS 279 Query: 241 KSSIGLNTWPIIRDLVDDIFTVTEDEIKCATQLVWERM 278 K + W R+ + V ++ I+ + ++ Sbjct: 280 KQA-KDAFWRYHRNTNYSV--VDDEVIRDLYRRGYDDE 314 >2DFV-A nrPDB Length = 347 Score = 28.9 bits (63), Expect = 3.2, Method: Composition-based stats. Identities = 22/144 (15%), Positives = 43/144 (29%), Gaps = 18/144 (12%) Query: 120 AYGASIVYCE-PSDESRENVAKRVTEETEGIMVHPNQE---------PAVIAGQGTIALE 169 YGA +V + P E + K + G +H + P I G E Sbjct: 13 GYGAELVEVDVPKPGPGEVLIKVLATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAG-E 71 Query: 170 VLNQVPLVDALVVP---VGGGGMLAGIAITVK----ALKPSVKVYAAEPSNADDCYQSKL 222 V+ P V+ + V ++ G + + + K++ + Y Sbjct: 72 VVEIGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDTDGVFAEYAVVP 131 Query: 223 KGKLMPNLYPPETIADGVKSSIGL 246 + N ++ +G Sbjct: 132 AQNIWKNPKSIPPEYATLQEPLGN 155 >1DXH-A nrPDB Length = 335 Score = 28.9 bits (63), Expect = 3.4, Method: Composition-based stats. Identities = 12/59 (20%), Positives = 19/59 (32%), Gaps = 6/59 (10%) Query: 86 NHGQALTYAAKLEGIPAYIVVPQT------APDCKKLAIQAYGASIVYCEPSDESRENV 138 N G +L G+ I P+ K + GA + E E+ + V Sbjct: 167 NMGNSLLLIGAKLGMDVRIAAPKALWPHDEFVAQCKKFAEESGAKLTLTEDPKEAVKGV 225 >3TK1-A nrPDB Length = 330 Score = 28.5 bits (62), Expect = 3.7, Method: Composition-based stats. Identities = 19/114 (16%), Positives = 35/114 (30%), Gaps = 11/114 (9%) Query: 176 LVDALVVPVGGGGMLAGIAITVKAL-----KPSVKVYAAEPSN---ADDCYQSKLKGKLM 227 DA V P G L G+A + V E ++ + + Sbjct: 116 HPDAYVRPSPSSGTLGGVAKATRETIVLLEAAGFDVVLVETVGVGQSEVTVADMVDTFVF 175 Query: 228 PNLYPPETIADGVKSSIGLNTWPIIRDLVDDIFTVTEDEIKCATQLVWERMKLL 281 L G+K + ++ + D V E + A + + M+L+ Sbjct: 176 LTLARTGDQLQGIKKGVLELADIVVVNKADGEHAV---EARKAARELAGAMRLI 226 >3NJR-A nrPDB Length = 204 Score = 28.5 bits (62), Expect = 3.7, Method: Composition-based stats. Identities = 24/87 (27%), Positives = 37/87 (42%), Gaps = 11/87 (12%) Query: 122 GASIVYCEPSDESRENVAKRVTEETEGIMVHPNQEPAVIAGQGTIALEVLNQVPLVDALV 181 G + EP + EN+ K + + P + A QGT A L +PL +A+ Sbjct: 77 GGRAITIEPRADRIENIQKNI-DTYGL-------SPRMRAVQGT-APAALADLPLPEAVF 127 Query: 182 VPVGGGGMLAGIAITVKALKPSVKVYA 208 +GGGG A + L P ++ A Sbjct: 128 --IGGGGSQALYDRLWEWLAPGTRIVA 152 >2WOV-A nrPDB Length = 495 Score = 28.5 bits (62), Expect = 3.7, Method: Composition-based stats. Identities = 13/65 (20%), Positives = 23/65 (35%), Gaps = 1/65 (1%) Query: 178 DALVVPVGGGGMLAGIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIA 237 D +V+ G GG+ AG V V + S+ Y + + P + + Sbjct: 9 DLVVIGAGSGGLEAG-WNAATLYGKRVAVVDVQTSHGPPFYAALGGTCVNVGCVPKKLMV 67 Query: 238 DGVKS 242 G + Sbjct: 68 TGAQY 72 >3JSK-A nrPDB Length = 344 Score = 28.5 bits (62), Expect = 3.8, Method: Composition-based stats. Identities = 22/133 (16%), Positives = 49/133 (36%), Gaps = 11/133 (8%) Query: 104 IVVPQTAPDCKKLAIQAYGASIVYCEPSDESRENVAKRVTEETEGIMVHPNQEPAVIAGQ 163 ++ PQ+ P + ++A G + P + ++K + E + + Sbjct: 5 VLEPQSVPTLVNVGLKAVGRN---DAPVERDARGLSKPLLELMPTLGTDAFTFSPIREST 61 Query: 164 GTIA-----LEVLNQVPLVDALVVPVGGGGMLAGIAITVKALKPSVKVYAAEPSNADDCY 218 + A L+ D ++V G G+ A A + L+P +++ E + Sbjct: 62 VSRAMTRRYFADLDAHAETDIVIVGAGSCGLSA--AYVLSTLRPDLRITIVE-AGVAPGG 118 Query: 219 QSKLKGKLMPNLY 231 + L G+L + Sbjct: 119 GAWLGGQLFSAMV 131 >6B6X-A nrPDB Length = 637 Score = 28.5 bits (62), Expect = 4.3, Method: Composition-based stats. Identities = 13/76 (17%), Positives = 30/76 (39%) Query: 57 IRGALNAVRSLVPDALERKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKL 116 IR + + + K +V ++ G+ L + G+P + + + + L Sbjct: 475 IRRDIMVLATGCVTTAAGKAGLLVPEAASKAGEGLAAVCRSLGVPPVLHMGSCVDNSRIL 534 Query: 117 AIQAYGASIVYCEPSD 132 + A A+ + + SD Sbjct: 535 QLCALLATTLGVDISD 550 >4MUZ-A nrPDB Length = 229 Score = 28.5 bits (62), Expect = 4.6, Method: Composition-based stats. Identities = 8/66 (12%), Positives = 19/66 (28%), Gaps = 3/66 (4%) Query: 19 IRDSIHLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVRSLVPDALERKPKA 78 + + + + + G ++ EL G +V A E Sbjct: 104 VHGFVGSDTLREVCRVAEEFGGKVYAVTELSSPGG---EEFMSAVSLKIVEKAKEAGCHG 160 Query: 79 VVTHSS 84 ++ S+ Sbjct: 161 LIAPST 166 >4JBE-A nrPDB Length = 445 Score = 28.5 bits (62), Expect = 4.7, Method: Composition-based stats. Identities = 24/140 (17%), Positives = 40/140 (28%), Gaps = 24/140 (17%) Query: 79 VVTHSSGNHGQALTYAAKLEGIPA--------YIVVPQTA-----------PDCKKLAIQ 119 V+ SG +AL A G+ + V + A + Sbjct: 236 VILRGSGESTRALALEAAQHGVRTLAHADGGGVLYVDEKADRDTVRSLVVNSLDRLGVCN 295 Query: 120 AYGASIVYCEPSDESRENVAKRVTEETEGIMVHPNQEPAVIAGQGTIALEVLNQVPLVDA 179 +++ +E V++ + E + P P E V VD Sbjct: 296 RLNLLLIHDAVYEEFWPVVSEALAERGVSPSLPPYDHPIGYEWALDSEREATVTVARVDG 355 Query: 180 LVVPV-----GGGGMLAGIA 194 + V G+ AGIA Sbjct: 356 VAEAVRIANEETSGLAAGIA 375 >2BR3-A nrPDB Length = 236 Score = 28.2 bits (61), Expect = 5.4, Method: Composition-based stats. Identities = 14/115 (12%), Positives = 35/115 (30%), Gaps = 10/115 (8%) Query: 170 VLNQVPLVDALVVPVGGGGMLAGIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPN 229 +L ++ + + V GG LA K + +V + + + + + Sbjct: 76 MLWELRPRTIVELGVYNGGSLAWFRDLTKIMGIDCQVIGIDRDLSRCQIPASDMENITLH 135 Query: 230 LYPPETIADGVKSSIGLNTWPIIRDLVDDIFTVTEDEIKCATQLVWERMKLLIEP 284 + T+ +R++ + + + + W LL E Sbjct: 136 QGDCSDLT----------TFEHLREMAHPLIFIDDAHANTFNIMKWAVDHLLEEG 180 >5JFC-L nrPDB Length = 474 Score = 28.2 bits (61), Expect = 5.8, Method: Composition-based stats. Identities = 18/100 (18%), Positives = 32/100 (32%), Gaps = 9/100 (9%) Query: 7 ISFADVEKAHINIRDSIH-LTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVR 65 I+F ++ + + I TP + L G ++ E + K A + Sbjct: 231 ITFEELREEYDAIFIGTGAGTPRIYPWPGVNLNG--IYSANEFLTRINLMK------AYK 282 Query: 66 SLVPDALERKPKAVVTHSSGNHGQALTYAAKLEGIPAYIV 105 D + K V GN +A G +I+ Sbjct: 283 FPEYDTPIKVGKRVAVIGGGNTAMDAARSALRLGAEVWIL 322 >1L3B-A nrPDB Length = 192 Score = 27.8 bits (60), Expect = 6.5, Method: Composition-based stats. Identities = 16/43 (37%), Positives = 22/43 (51%), Gaps = 2/43 (4%) Query: 167 ALEVLNQVPLVDALVVPVGGGGMLAGIAITVK-ALKPSVKVYA 208 A E L ++P +D VV G GG L I +K LKP ++ Sbjct: 91 APEALCKIPDIDIAVVG-GSGGELQEILRIIKDKLKPGGRIIV 132 >5EB4-A nrPDB Length = 532 Score = 27.8 bits (60), Expect = 7.6, Method: Composition-based stats. Identities = 13/65 (20%), Positives = 24/65 (36%), Gaps = 6/65 (9%) Query: 280 LLIEPTAGVGVAAVLSQHFQTVSPEVKNIC------IVLSGGNVDLTSSITWVKQAERPA 333 ++ T+G +AA LS+ ++ + E I + G +L ER Sbjct: 31 VIGGGTSGCPLAATLSEKYKVLLLERGTIATEYPNTLTADGFAYNLQQQDDGKTPVERFV 90 Query: 334 SYQSV 338 S + Sbjct: 91 SEDGI 95 >3AOE-E nrPDB Length = 419 Score = 27.8 bits (60), Expect = 7.6, Method: Composition-based stats. Identities = 14/69 (20%), Positives = 23/69 (33%), Gaps = 4/69 (5%) Query: 59 GALNAVRSLVPD-ALERKPKAVVTHSSGNHGQALTYAAKLEGIPAYIV---VPQTAPDCK 114 GAL + +L L+ + VV G G A+ A+ G+ V + Sbjct: 200 GALLVLEALAKRRGLDLRGARVVVQGLGQVGAAVALHAERLGMRVVAVATSMGGMYAPEG 259 Query: 115 KLAIQAYGA 123 + A Sbjct: 260 LDVAEVLSA 268 >2YAU-A nrPDB Length = 511 Score = 27.8 bits (60), Expect = 8.0, Method: Composition-based stats. Identities = 15/82 (18%), Positives = 29/82 (35%), Gaps = 6/82 (7%) Query: 178 DALVVPVGGGGMLAGIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIA 237 D +V+ G GG+ AG K V V + ++ + + + P + + Sbjct: 26 DLVVLGAGSGGLEAG-WNAAVTHKKKVAVVDVQATHGPPLFAALGGTCVNVGCVPKKLMV 84 Query: 238 DGVKS-----SIGLNTWPIIRD 254 G + G W + R+ Sbjct: 85 TGAQYMDLIRESGGFGWEMDRE 106 >4R16-A nrPDB Length = 418 Score = 27.4 bits (59), Expect = 9.5, Method: Composition-based stats. Identities = 45/326 (13%), Positives = 100/326 (30%), Gaps = 77/326 (23%) Query: 55 FKIRGALNAVRSLVPDALERKPKAVVTHSSGNHGQALTYAAKLEGIPAYI------VVPQ 108 RGAL + S +P K ++ + +G EG+ Y+ V+P Sbjct: 107 VMDRGALVIIESTIPPGTTEKMARLLENLTG----------LREGVDFYVAHAPERVMPG 156 Query: 109 TAPDCKKLAIQAYG-------------------ASIVYCEPSDESRENVAKRVTEETEGI 149 + G I + + + + Sbjct: 157 RIFKELVYNSRIIGGVSEKAANLAEKLYRSFVKGRIFLTNATTAEMVKLMENTFRDVNIA 216 Query: 150 MVHPNQEPAVIAGQ----GTIALEVLNQVPLVDALVVPVGGGG---------MLA----- 191 + + A++A Q A+E+ N P V +G GG +L+ Sbjct: 217 LANEF---ALLAHQYGVNVYEAIELANTHPRVKIHTPGIGVGGHCLPKDPYLLLSNAKED 273 Query: 192 -GIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETI-------ADGVKSS 243 G+ + + + +A A +++ K + P+ + D ++S Sbjct: 274 FGLIRIARRINERMPAFA-----AGLLFEALEKANIKPSEAIIAVLGLAYKGGTDDTRNS 328 Query: 244 IGLNTWPIIRDLVDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQ---T 300 L IIR+ V ++ T + + ++ ++E + +A + Sbjct: 329 PALKFVEIIRNSVKEVRTYD-----PYVRGTHDSLEKVVEGADAIVIATDHPEFKSVNWE 383 Query: 301 VSPEVKNICIVLSGGNVDLTSSITWV 326 + I++ G N+ + ++ Sbjct: 384 SIGKSMRHKIIIDGRNIIKEPPVGFI 409 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.310 0.130 0.321 Lambda K H 0.267 0.0404 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 11,545,720 Number of Sequences: 36641 Number of extensions: 423832 Number of successful extensions: 2068 Number of sequences better than 10.0: 128 Number of HSP's better than 10.0 without gapping: 130 Number of HSP's successfully gapped in prelim test: 67 Number of HSP's that attempted gapping in prelim test: 1599 Number of HSP's gapped (non-prelim): 210 length of query: 340 length of database: 10,336,785 effective HSP length: 98 effective length of query: 242 effective length of database: 6,745,967 effective search space: 1632524014 effective search space used: 1632524014 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.3 bits) S2: 59 (27.4 bits)