BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q9EQZ6 (1011 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 4F7Z-A nrPDB 2040 0.0 4MGY-E nrPDB 1436 0.0 1O7F-A nrPDB 933 0.0 1XDV-A nrPDB 92 1e-18 5OVF-A nrPDB 91 2e-18 2DHZ-A nrPDB 89 1e-17 2IJE-S nrPDB 89 1e-17 6EIE-A nrPDB 89 1e-17 3QXL-A nrPDB 81 2e-15 2D93-A nrPDB 69 1e-11 1WGY-A nrPDB 64 5e-10 4L9M-A nrPDB 60 4e-09 4DIN-B nrPDB 59 1e-08 5KBF-A nrPDB 58 3e-08 5V4S-A nrPDB 57 3e-08 6BQ8-A nrPDB 55 2e-07 6AXF-A nrPDB 54 3e-07 6BYS-B nrPDB 54 3e-07 6CJQ-A nrPDB 54 4e-07 5CM8-A nrPDB 53 5e-07 2QCS-B nrPDB 53 6e-07 5DYK-A nrPDB 52 1e-06 6AXG-A nrPDB 50 4e-06 5J3U-A nrPDB 50 4e-06 5FET-A nrPDB 49 1e-05 3J4Q-B nrPDB 48 2e-05 4EV0-A nrPDB 48 2e-05 4Z07-A nrPDB 47 4e-05 3SHR-A nrPDB 47 4e-05 2QVS-B nrPDB 47 6e-05 1CX4-A nrPDB 45 1e-04 5JAX-A nrPDB 45 2e-04 4QX5-A nrPDB 45 2e-04 4X6Q-B nrPDB 45 2e-04 4CHV-A nrPDB 41 0.002 6FTF-B nrPDB 40 0.004 4I0B-A nrPDB 40 0.004 3KCC-A nrPDB 40 0.004 4CYD-A nrPDB 36 0.066 3T6G-A nrPDB 36 0.11 5H3O-A nrPDB 35 0.14 1FSH-A nrPDB 35 0.20 1S94-A nrPDB 34 0.33 3I59-A nrPDB 33 0.54 1V3F-A nrPDB 33 0.72 3DKW-A nrPDB 33 0.89 3ML6-A nrPDB 32 1.4 5VA1-A nrPDB 32 1.4 2Y6I-A nrPDB 31 2.6 5SUY-A nrPDB 31 2.9 3IWZ-A nrPDB 31 3.0 4L11-A nrPDB 31 3.2 2N7G-A nrPDB 30 3.9 >4F7Z-A nrPDB Length = 999 Score = 2040 bits (5285), Expect = 0.0, Method: Compositional matrix adjust. Identities = 992/1011 (98%), Positives = 992/1011 (98%), Gaps = 18/1011 (1%) Query: 1 MVAAHAAHSQSSAEWIACLDKRPLERSSEDVDIIFTRLKGVKAFEKFHPNLLRQICLCGY 60 MVAAHAAHSQSSAEWIACLDKRPLERSSEDVDIIFTRLKGVKAFEKFHPNLLRQICLCGY Sbjct: 7 MVAAHAAHSQSSAEWIACLDKRPLERSSEDVDIIFTRLKGVKAFEKFHPNLLRQICLCGY 66 Query: 61 YENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGESILDN 120 YENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGESILDN Sbjct: 67 YENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGESILDN 126 Query: 121 TPRHATIVTRESSELLRIEQEDFKALWEKYRQYMAGLLAPPYGVMETGSNNDRIPDKENT 180 TPRHATIVTRESSELLRIEQEDFKALWEKYRQYMAGLLAPPYGVMETGSNNDRIPDKEN Sbjct: 127 TPRHATIVTRESSELLRIEQEDFKALWEKYRQYMAGLLAPPYGVMETGSNNDRIPDKEN- 185 Query: 181 PLIEPHVPLRPAHTITKVPSEKILRAGKILRIAILSRAPHMIRDRKYHLKTYRQCCVGTE 240 VPSEKILRAGKILRIAILSRAPHMIRDRKYHLKTYRQCCVGTE Sbjct: 186 -----------------VPSEKILRAGKILRIAILSRAPHMIRDRKYHLKTYRQCCVGTE 228 Query: 241 LVDWMIQQTSCVHSRTQAVGMWQVLLEDGVLNHVDQERHFQDKYLFYRFLDDEREDAPLP 300 LVDWMIQQTSCVHSRTQAVGMWQVLLEDGVLNHVDQERHFQDKYLFYRFLDDEREDAPLP Sbjct: 229 LVDWMIQQTSCVHSRTQAVGMWQVLLEDGVLNHVDQERHFQDKYLFYRFLDDEREDAPLP 288 Query: 301 TEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYDELLHIKALSHL 360 TEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYDELLHIKALSHL Sbjct: 289 TEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYDELLHIKALSHL 348 Query: 361 STTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDD 420 STTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDD Sbjct: 349 STTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDD 408 Query: 421 FGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKV 480 FGKLALVNDAPRAASIVLREDNCHFLRVDKED NRILRDVEANTVRLKEHDQDVLVLEKV Sbjct: 409 FGKLALVNDAPRAASIVLREDNCHFLRVDKEDGNRILRDVEANTVRLKEHDQDVLVLEKV 468 Query: 481 PAGNRAANQGNSQPQQKYTVMSGTPEKILEHFLETIRLEPSLNEATDSVLNDFVMMHCVF 540 PAGNRAANQGNSQPQQKYTVMSGTPEKILEHFLETIRLEPSLNEATDSVLNDFVMMHCVF Sbjct: 469 PAGNRAANQGNSQPQQKYTVMSGTPEKILEHFLETIRLEPSLNEATDSVLNDFVMMHCVF 528 Query: 541 MPNTQLCPALVAHYHAQPSQGTEQERMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVAMA 600 MPNTQLCPALVAHYHAQPSQGTEQERMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVAMA Sbjct: 529 MPNTQLCPALVAHYHAQPSQGTEQERMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVAMA 588 Query: 601 FLEEFYVSVSDDARMMAAFKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQK 660 FLEEFYVSVSDDARMMAAFKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQK Sbjct: 589 FLEEFYVSVSDDARMMAAFKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQK 648 Query: 661 RQPIRGSDEVLFKVYCIDHTYTTIRVPVAASVKEVISAVADKLGSGEGLIIVKMNSGGEK 720 RQPIRGSDEVLFKVYCIDHTYTTIRVPVAASVKEVISAVADKLGSGEGLIIVKMNSGGEK Sbjct: 649 RQPIRGSDEVLFKVYCIDHTYTTIRVPVAASVKEVISAVADKLGSGEGLIIVKMNSGGEK 708 Query: 721 VVLKSNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTTGTVGTFELMSSKDLAYQM 780 VVLKSNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTTGTVGTFELMSSKDLAYQM Sbjct: 709 VVLKSNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTTGTVGTFELMSSKDLAYQM 768 Query: 781 TTYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEVCLCSQLSKR 840 TTYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEVCLCSQLSKR Sbjct: 769 TTYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEVCLCSQLSKR 828 Query: 841 VQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLM 900 VQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLM Sbjct: 829 VQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLM 888 Query: 901 DPSRNHRAYRLTAAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTART 960 DPSRNHRAYRLTAAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTART Sbjct: 889 DPSRNHRAYRLTAAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTART 948 Query: 961 VRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP 1011 VRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP Sbjct: 949 VRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP 999 >4MGY-E nrPDB Length = 694 Score = 1436 bits (3718), Expect = 0.0, Method: Compositional matrix adjust. Identities = 687/688 (99%), Positives = 688/688 (100%) Query: 324 PDAHMRMILRKPPGQRTVDDLEIIYDELLHIKALSHLSTTVKRELAGVLIFESHAKGGTV 383 PDAHMRMILRKPPGQRTVDDLEIIYDELLHIKALSHLSTTVKRELAGVLIFESHAKGGTV Sbjct: 7 PDAHMRMILRKPPGQRTVDDLEIIYDELLHIKALSHLSTTVKRELAGVLIFESHAKGGTV 66 Query: 384 LFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNC 443 LFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFG+LALVNDAPRAASIVLREDNC Sbjct: 67 LFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGQLALVNDAPRAASIVLREDNC 126 Query: 444 HFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVPAGNRAANQGNSQPQQKYTVMSG 503 HFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVPAGNRAANQGNSQPQQKYTVMSG Sbjct: 127 HFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVPAGNRAANQGNSQPQQKYTVMSG 186 Query: 504 TPEKILEHFLETIRLEPSLNEATDSVLNDFVMMHCVFMPNTQLCPALVAHYHAQPSQGTE 563 TPEKILEHFLETIRLEPSLNEATDSVLNDFVMMHCVFMPNTQLCPALVAHYHAQPSQGTE Sbjct: 187 TPEKILEHFLETIRLEPSLNEATDSVLNDFVMMHCVFMPNTQLCPALVAHYHAQPSQGTE 246 Query: 564 QERMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVAMAFLEEFYVSVSDDARMMAAFKEQL 623 QERMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVAMAFLEEFYVSVSDDARMMAAFKEQL Sbjct: 247 QERMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVAMAFLEEFYVSVSDDARMMAAFKEQL 306 Query: 624 PELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRGSDEVLFKVYCIDHTYTT 683 PELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRGSDEVLFKVYCIDHTYTT Sbjct: 307 PELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRGSDEVLFKVYCIDHTYTT 366 Query: 684 IRVPVAASVKEVISAVADKLGSGEGLIIVKMNSGGEKVVLKSNDVSVFTTLTINGRLFAC 743 IRVPVAASVKEVISAVADKLGSGEGLIIVKMNSGGEKVVLKSNDVSVFTTLTINGRLFAC Sbjct: 367 IRVPVAASVKEVISAVADKLGSGEGLIIVKMNSGGEKVVLKSNDVSVFTTLTINGRLFAC 426 Query: 744 PREQFDSLTPLPEQEGPTTGTVGTFELMSSKDLAYQMTTYDWELFNCVHELELIYHTFGR 803 PREQFDSLTPLPEQEGPTTGTVGTFELMSSKDLAYQMTTYDWELFNCVHELELIYHTFGR Sbjct: 427 PREQFDSLTPLPEQEGPTTGTVGTFELMSSKDLAYQMTTYDWELFNCVHELELIYHTFGR 486 Query: 804 HNFKKTTANLDLFLRRFNEIQFWVVTEVCLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSF 863 HNFKKTTANLDLFLRRFNEIQFWVVTEVCLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSF Sbjct: 487 HNFKKTTANLDLFLRRFNEIQFWVVTEVCLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSF 546 Query: 864 FAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTAAKLEPPLIPF 923 FAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTAAKLEPPLIPF Sbjct: 547 FAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTAAKLEPPLIPF 606 Query: 924 MPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQDV 983 MPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQDV Sbjct: 607 MPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQDV 666 Query: 984 RSYVRQLNVIDNQRTLSQMSHRLEPRRP 1011 RSYVRQLNVIDNQRTLSQMSHRLEPRRP Sbjct: 667 RSYVRQLNVIDNQRTLSQMSHRLEPRRP 694 Score = 77.0 bits (188), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 45/128 (35%), Positives = 75/128 (58%), Gaps = 9/128 (7%) Query: 19 LDKRPLERSSEDVDIIFTRLKGVKAFEKFHPNLLRQICLCGYYENLEKGIT-LFRQGDIG 77 L K P +R+ +D++II+ L +KA + R++ +E+ KG T LF QG+ G Sbjct: 15 LRKPPGQRTVDDLEIIYDELLHIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEG 74 Query: 78 TNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGE-SILDNTPRHATIVTRESS-EL 135 T+WY +L GS++V + +CTL G FG+ +++++ PR A+IV RE + Sbjct: 75 TSWYIILKGSVNVVIYGKG------VVCTLHEGDDFGQLALVNDAPRAASIVLREDNCHF 128 Query: 136 LRIEQEDF 143 LR+++EDF Sbjct: 129 LRVDKEDF 136 >1O7F-A nrPDB Length = 469 Score = 933 bits (2412), Expect = 0.0, Method: Compositional matrix adjust. Identities = 463/481 (96%), Positives = 463/481 (96%), Gaps = 18/481 (3%) Query: 1 MVAAHAAHSQSSAEWIACLDKRPLERSSEDVDIIFTRLKGVKAFEKFHPNLLRQICLCGY 60 MVAAHAAHSQSSAEWIACLDKRPLERSSEDVDIIFTRLKGVKAFEKFHPNLLRQICLCGY Sbjct: 7 MVAAHAAHSQSSAEWIACLDKRPLERSSEDVDIIFTRLKGVKAFEKFHPNLLRQICLCGY 66 Query: 61 YENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGESILDN 120 YENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGESILDN Sbjct: 67 YENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGESILDN 126 Query: 121 TPRHATIVTRESSELLRIEQEDFKALWEKYRQYMAGLLAPPYGVMETGSNNDRIPDKENT 180 TPRHATIVTRESSELLRIEQEDFKALWEKYRQYMAGLLAPPYGVMETGSNNDRIPDKEN Sbjct: 127 TPRHATIVTRESSELLRIEQEDFKALWEKYRQYMAGLLAPPYGVMETGSNNDRIPDKEN- 185 Query: 181 PLIEPHVPLRPAHTITKVPSEKILRAGKILRIAILSRAPHMIRDRKYHLKTYRQCCVGTE 240 VPSEKILRAGKILRIAILSRAPHMIRDRKYHLKTYRQCCVGTE Sbjct: 186 -----------------VPSEKILRAGKILRIAILSRAPHMIRDRKYHLKTYRQCCVGTE 228 Query: 241 LVDWMIQQTSCVHSRTQAVGMWQVLLEDGVLNHVDQERHFQDKYLFYRFLDDEREDAPLP 300 LVDWMIQQTSCVHSRTQAVGMWQVLLEDGVLNHVDQERHFQDKYLFYRFLDDEREDAPLP Sbjct: 229 LVDWMIQQTSCVHSRTQAVGMWQVLLEDGVLNHVDQERHFQDKYLFYRFLDDEREDAPLP 288 Query: 301 TEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYDELLHIKALSHL 360 TEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYDELLHIKALSHL Sbjct: 289 TEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYDELLHIKALSHL 348 Query: 361 STTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDD 420 STTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDD Sbjct: 349 STTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDD 408 Query: 421 FGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKV 480 FGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKV Sbjct: 409 FGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKV 468 Query: 481 P 481 P Sbjct: 469 P 469 >1XDV-A nrPDB Length = 847 Score = 91.7 bits (226), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 67/276 (24%), Positives = 124/276 (44%), Gaps = 20/276 (7%) Query: 748 FDSLTPLPEQEGPTTGTVGTFELMS--SKDLAYQMTTYDWELFNCVHELELIYHTFGRHN 805 F S P E G + TF+L++ ++A Q+T + +L+ V EL+ + + + Sbjct: 557 FQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKED 616 Query: 806 FKKTTANLDLFLRRFNEIQFWVVTEVCLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFA 865 + + NL +R + W + L +RV ++ + I+I +E N N Sbjct: 617 KEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLE 676 Query: 866 IVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTAAKLEPPLIPFMP 925 +V +++ V RL T+E++PS+ KK E L + +++ Y + PP +PF Sbjct: 677 VVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSE--DHYKKYLAKLRSINPPCVPFFG 734 Query: 926 LLIKDMTFTHEGNKTFI----DNLVNFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQ 981 + + ++ T EGN + L+NF K R +A ++ Y++QP+ + Sbjct: 735 IYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPY------CLRVES 788 Query: 982 DVRSYVRQLNVIDNQRT------LSQMSHRLEPRRP 1011 D++ + LN + N L S +EPR P Sbjct: 789 DIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNP 824 >5OVF-A nrPDB Length = 490 Score = 91.3 bits (225), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 67/276 (24%), Positives = 124/276 (44%), Gaps = 20/276 (7%) Query: 748 FDSLTPLPEQEGPTTGTVGTFELMS--SKDLAYQMTTYDWELFNCVHELELIYHTFGRHN 805 F S P E G + TF+L++ ++A Q+T + +L+ V EL+ + + + Sbjct: 195 FQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKED 254 Query: 806 FKKTTANLDLFLRRFNEIQFWVVTEVCLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFA 865 + + NL +R + W + L +RV ++ + I+I +E N N Sbjct: 255 KEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLE 314 Query: 866 IVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTAAKLEPPLIPFMP 925 +V +++ V RL T+E++PS+ KK E L + +++ Y + PP +PF Sbjct: 315 VVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSE--DHYKKYLAKLRSINPPCVPFFG 372 Query: 926 LLIKDMTFTHEGNKTFI----DNLVNFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQ 981 + + ++ T EGN + L+NF K R +A ++ Y++QP+ + Sbjct: 373 IYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPY------CLRVES 426 Query: 982 DVRSYVRQLNVIDNQRT------LSQMSHRLEPRRP 1011 D++ + LN + N L S +EPR P Sbjct: 427 DIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNP 462 >2DHZ-A nrPDB Length = 120 Score = 89.0 bits (219), Expect = 1e-17, Method: Composition-based stats. Identities = 45/113 (39%), Positives = 70/113 (61%), Gaps = 17/113 (15%) Query: 668 DEVLFKVYCIDHTYTTIRVPVAASVKEVISAVADKL-------GSGEGLIIVKMNSGGEK 720 DE+ +VY DH+Y TIR ++ASV++++ +V +KL G + LI+V ++S GEK Sbjct: 8 DEIFCRVYMPDHSYVTIRSRLSASVQDILGSVTEKLQYSEEPAGREDSLILVAVSSSGEK 67 Query: 721 VVLKSNDVSVFTTLTINGRLFACPREQFDSLTPLPEQ----------EGPTTG 763 V+L+ + VFT L IN LFAC R+ +++L PLPE+ GP++G Sbjct: 68 VLLQPTEDCVFTALGINSHLFACTRDSYEALVPLPEEIQVSPGDTEISGPSSG 120 >2IJE-S nrPDB Length = 240 Score = 89.0 bits (219), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 56/243 (23%), Positives = 113/243 (46%), Gaps = 7/243 (2%) Query: 770 LMSSKDLAYQMTTYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVT 829 L S+ ++A Q+T D +F + E + + + T + + FN + ++ + Sbjct: 3 LGSALEIAEQLTLLDHLVFKSIPYEEFFGQGWMKAEKYERTPYIMKTTKHFNHVSNFIAS 62 Query: 830 EVCLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKF 889 E+ +S R ++K++ +A C+ N N+ I ++ A+ RL TW K+ + Sbjct: 63 EIIRNEDISARASAIEKWVAVADICRCLHNYNAVLEITSSINRSAIFRLKKTWLKVSKQT 122 Query: 890 KKFYAEFESLMDPSRNHRAYRLTAAKLEPPLIPFMPLLIKDMTFTHEGNKTFI-DNLVNF 948 K + + L+ + R + +PP +P++ + + D+ F EG + D LVNF Sbjct: 123 KSLLDKLQKLVSSDGRFKNLRESLRNCDPPCVPYLGMYLTDLVFIEEGTPNYTEDGLVNF 182 Query: 949 EKMRMIANTARTVRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEP 1008 KMRMI++ R +R ++ + D V Y+ + + ++ +L + S +EP Sbjct: 183 SKMRMISHIIREIRQFQQTTYKIDP------QPKVIQYLLDESFMLDEESLYESSLLIEP 236 Query: 1009 RRP 1011 + P Sbjct: 237 KLP 239 >6EIE-A nrPDB Length = 490 Score = 88.6 bits (218), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 70/277 (25%), Positives = 127/277 (45%), Gaps = 22/277 (7%) Query: 748 FDSLTPLPEQEGPTTGTVGTFELMS--SKDLAYQMTTYDWELFNCVHELELIYHTFGRHN 805 F+S P E G + TF+LM+ ++A Q+T + +L+ V EL+ + + + Sbjct: 195 FESPPPPIEWHISKPGHIETFDLMTLHPIEIARQLTLLESDLYRKVQPSELVGSVWTKED 254 Query: 806 FKKTTANLDLFLRRFNEIQFWVVTEVCLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFA 865 + + NL +R + W + +RV +L + I+I ++ N N Sbjct: 255 KEINSPNLLKMIRHTTNLTLWFEKCIVEAENFEERVAVLSRIIEILQVFQDLNNFNGVLE 314 Query: 866 IVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNH-RAYRLTAAKLEPPLIPFM 924 IV +++V+V RL T+E L + +K E L S++H + Y + + PP +PF Sbjct: 315 IVSAVNSVSVYRLDHTFEALQERKRKILDEAVEL---SQDHFKKYLVKLKSINPPCVPFF 371 Query: 925 PLLIKDMTFTHEGNKTFI----DNLVNFEKMRMIANTARTVRYYRSQPFNPDAAQANKNH 980 + + ++ T EGN F+ +L+NF K R +A ++ Y++QP+ + Sbjct: 372 GIYLTNILKTEEGNNDFLTRHGKDLINFSKRRKVAEITGEIQQYQNQPY------CLRIE 425 Query: 981 QDVRSYVRQLNVIDNQRT------LSQMSHRLEPRRP 1011 D+R + LN + + L S +EPR P Sbjct: 426 PDMRRFFENLNPMGSASEKEFTDYLFNKSLEIEPRNP 462 >3QXL-A nrPDB Length = 271 Score = 80.9 bits (198), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 47/164 (28%), Positives = 80/164 (48%), Gaps = 1/164 (0%) Query: 771 MSSKDLAYQMTTYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTE 830 ++ ++ A Q+T D +F + EL + + N+ F RRFN++ FWVV E Sbjct: 31 VTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPNVVAFTRRFNQVSFWVVRE 90 Query: 831 VCLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFK 890 + L R ++L F+KIA E NL+S ++V L + + RL TW L K K Sbjct: 91 ILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFRLTKTWALLNRKDK 150 Query: 891 KFYAEFESLMDPSRNHRAYRLTAAKLE-PPLIPFMPLLIKDMTF 933 + + + LM N++ R L+ P IP++ + + D+ + Sbjct: 151 TTFEKLDYLMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIY 194 >2D93-A nrPDB Length = 134 Score = 68.6 bits (166), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 36/113 (31%), Positives = 64/113 (56%), Gaps = 2/113 (1%) Query: 350 ELLH-IKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYG 408 E +H + A ++++ +V+REL V+IFE + G ++ G+E SWY+IL G+V + + Sbjct: 16 EFMHQLPAFANMTMSVRRELCSVMIFEVVEQAGAIILEDGQELDSWYVILNGTVEIS-HP 74 Query: 409 KGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVE 461 G V L G+ FG ++ + + D+C F+ + ++D+ RIL VE Sbjct: 75 DGKVENLFMGNSFGITPTLDKQYMHGIVRTKVDDCQFVCIAQQDYWRILNHVE 127 >1WGY-A nrPDB Length = 104 Score = 63.5 bits (153), Expect = 5e-10, Method: Composition-based stats. Identities = 29/97 (29%), Positives = 58/97 (59%), Gaps = 1/97 (1%) Query: 668 DEVLFKVYCIDHTYTTIRVPVAASVKEVISAVADKLG-SGEGLIIVKMNSGGEKVVLKSN 726 +E+ VY +H+Y +++ V++ +E++ VA+K+ + E L +V + GEK L+ N Sbjct: 8 EEIFCHVYITEHSYVSVKAKVSSIAQEILKVVAEKIQYAEEDLALVAITFSGEKHELQPN 67 Query: 727 DVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTTG 763 D+ + +L +GR++ ++ D+L P E GP++G Sbjct: 68 DLVISKSLEASGRIYVYRKDLADTLNPFAENSGPSSG 104 >4L9M-A nrPDB Length = 559 Score = 60.5 bits (145), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 49/191 (25%), Positives = 86/191 (45%), Gaps = 8/191 (4%) Query: 821 NEIQFWVVTEVCLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLAL 880 N I WV V R ++ KFI++A + +N N+ A++ GL + ++SRL Sbjct: 204 NGISQWVQLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKE 263 Query: 881 TWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTAAKLEPPLIPFMPLLIKDMTFTHEGNKT 940 T +P + K E L+ SRN+ YR + IP + + +KD+ +E Sbjct: 264 TSSHVPHEINKVLGEMTELLSSSRNYDNYRRAYGECTDFKIPILGVHLKDLISLYEAMPD 323 Query: 941 FI-DNLVNFEKMRMIAN-TARTVRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRT 998 ++ D VN K+ + N + V+ P +ANK+ V L++ + Sbjct: 324 YLEDGKVNVHKLLALYNHISELVQLQEVAP----PLEANKDL--VHLLTLSLDLYYTEDE 377 Query: 999 LSQMSHRLEPR 1009 + ++S+ EPR Sbjct: 378 IYELSYAREPR 388 >4DIN-B nrPDB Length = 381 Score = 58.9 bits (141), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 32/101 (31%), Positives = 57/101 (56%), Gaps = 3/101 (2%) Query: 357 LSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLH 416 +HL + ++ + +H G TV+ QG EG ++Y++ +G V+V + G+ V + Sbjct: 138 FAHLDDNERSDIFDAMFPVTHIAGETVI-QQGNEGDNFYVVDQGEVDVYVNGEWVT-NIS 195 Query: 417 EGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRIL 457 EG FG+LAL+ PRAA++ + D +D++ + RIL Sbjct: 196 EGGSFGELALIYGTPRAATVKAKTD-LKLWGIDRDSYRRIL 235 Score = 40.8 bits (94), Expect = 0.003, Method: Compositional matrix adjust. Identities = 27/82 (32%), Positives = 44/82 (53%), Gaps = 6/82 (7%) Query: 381 GTVLFNQGEEGTSWYIILKGSVNVVIYGKG-----VVCTLHEGDDFGKLALVNDAPRAAS 435 G + QGE G +YII +G+ +V+ V L D FG++AL+ + PRAA+ Sbjct: 279 GEKIVVQGEPGDDFYIITEGTASVLQRRSPNEEYVEVGRLGPSDYFGEIALLLNRPRAAT 338 Query: 436 IVLREDNCHFLRVDKEDFNRIL 457 +V R +++D+ F R+L Sbjct: 339 VVAR-GPLKCVKLDRPRFERVL 359 Score = 40.4 bits (93), Expect = 0.004, Method: Compositional matrix adjust. Identities = 24/82 (29%), Positives = 45/82 (54%), Gaps = 2/82 (2%) Query: 64 LEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGE-SILDNTP 122 E G + QG+ G ++Y + G+ V + S +++ V + LG FGE ++L N P Sbjct: 276 FEDGEKIVVQGEPGDDFYIITEGTASV-LQRRSPNEEYVEVGRLGPSDYFGEIALLLNRP 334 Query: 123 RHATIVTRESSELLRIEQEDFK 144 R AT+V R + +++++ F+ Sbjct: 335 RAATVVARGPLKCVKLDRPRFE 356 Score = 39.7 bits (91), Expect = 0.006, Method: Compositional matrix adjust. Identities = 23/81 (28%), Positives = 44/81 (54%), Gaps = 8/81 (9%) Query: 67 GITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGE-SILDNTPRHA 125 G T+ +QG+ G N+Y V G +DV V + + + G +FGE +++ TPR A Sbjct: 161 GETVIQQGNEGDNFYVVDQGEVDVYV-------NGEWVTNISEGGSFGELALIYGTPRAA 213 Query: 126 TIVTRESSELLRIEQEDFKAL 146 T+ + +L I+++ ++ + Sbjct: 214 TVKAKTDLKLWGIDRDSYRRI 234 >5KBF-A nrPDB Length = 301 Score = 57.8 bits (138), Expect = 3e-08, Method: Composition-based stats. Identities = 39/130 (30%), Positives = 75/130 (57%), Gaps = 4/130 (3%) Query: 347 IYDELL-HIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVV 405 +Y+++L H+ L + + ++A L +S+ G ++ +GEEG +++I++ G+ V Sbjct: 162 MYEDILSHVNILKDMDPYERCKVADCLKSKSY-NDGEIIIKEGEEGDTFFILIDGNA-VA 219 Query: 406 IYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTV 465 V+ T +GD FG+LAL+ + PRAA+I ++ C + +D++ F R+L +E Sbjct: 220 SKDNKVIKTYTKGDYFGELALLKNKPRAATIK-AQNFCQVVYLDRKSFKRLLGPIEDILH 278 Query: 466 RLKEHDQDVL 475 R E+ + VL Sbjct: 279 RNVENYKKVL 288 Score = 48.9 bits (115), Expect = 1e-05, Method: Composition-based stats. Identities = 30/100 (30%), Positives = 52/100 (52%), Gaps = 5/100 (5%) Query: 374 FESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIY----GKGVVCTLHEGDDFGKLALVND 429 F+ + + G + N+G+ G Y+I +G V + K V+ L D FG+LAL+ + Sbjct: 66 FDKNVEKGVNIINEGDYGDLLYVIDQGEVEIYKTKENNKKEVLTVLKSKDVFGELALLYN 125 Query: 430 APRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKE 469 + RAA+ CH +D+E F I++D+ A ++ E Sbjct: 126 SKRAATATALT-KCHLWALDRESFTYIIKDMVAKKRKMYE 164 Score = 38.5 bits (88), Expect = 0.016, Method: Composition-based stats. Identities = 22/83 (26%), Positives = 45/83 (54%), Gaps = 3/83 (3%) Query: 62 ENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGE-SILDN 120 +N+EKG+ + +GD G Y + G +++ ++ ++ ++ +T+ L FGE ++L N Sbjct: 68 KNVEKGVNIINEGDYGDLLYVIDQGEVEIYKTKENNKKEVLTV--LKSKDVFGELALLYN 125 Query: 121 TPRHATIVTRESSELLRIEQEDF 143 + R AT L +++E F Sbjct: 126 SKRAATATALTKCHLWALDRESF 148 Score = 32.7 bits (73), Expect = 0.90, Method: Composition-based stats. Identities = 25/108 (23%), Positives = 52/108 (48%), Gaps = 16/108 (14%) Query: 48 HPNLLR--------QICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQ 99 H N+L+ ++ C ++ G + ++G+ G ++ ++ G+ + + Sbjct: 169 HVNILKDMDPYERCKVADCLKSKSYNDGEIIIKEGEEGDTFFILIDGN-------AVASK 221 Query: 100 DAVTICTLGIGTAFGE-SILDNTPRHATIVTRESSELLRIEQEDFKAL 146 D I T G FGE ++L N PR ATI + +++ ++++ FK L Sbjct: 222 DNKVIKTYTKGDYFGELALLKNKPRAATIKAQNFCQVVYLDRKSFKRL 269 >5V4S-A nrPDB Length = 465 Score = 57.4 bits (137), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 31/79 (39%), Positives = 49/79 (62%), Gaps = 2/79 (2%) Query: 381 GTVLFNQGEEGTSWYIILKGSVNVVIYG-KGVVCTLHEGDDFGKLALVNDAPRAASIVLR 439 G +F +GE+G YI+ +GSV+++ K ++ +L EG FG+LALV DAPR+A+ V Sbjct: 369 GDTIFRRGEKGDDLYILSEGSVDILDSDEKTILLSLQEGQFFGELALVMDAPRSAT-VRA 427 Query: 440 EDNCHFLRVDKEDFNRILR 458 C + K DF+ +L+ Sbjct: 428 TTTCEIYTLSKTDFDNVLK 446 Score = 40.8 bits (94), Expect = 0.003, Method: Compositional matrix adjust. Identities = 24/93 (25%), Positives = 52/93 (55%), Gaps = 6/93 (6%) Query: 66 KGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGE-SILDNTPRH 124 +G T+FR+G+ G + Y + GS+D+ S+ + + +L G FGE +++ + PR Sbjct: 368 EGDTIFRRGEKGDDLYILSEGSVDILDSD-----EKTILLSLQEGQFFGELALVMDAPRS 422 Query: 125 ATIVTRESSELLRIEQEDFKALWEKYRQYMAGL 157 AT+ + E+ + + DF + +++ Q+ + + Sbjct: 423 ATVRATTTCEIYTLSKTDFDNVLKRFSQFRSAI 455 >6BQ8-A nrPDB Length = 152 Score = 55.1 bits (131), Expect = 2e-07, Method: Composition-based stats. Identities = 29/86 (33%), Positives = 53/86 (61%), Gaps = 5/86 (5%) Query: 381 GTVLFNQGEEGTSWYIILKGSVNVVIYGKG-----VVCTLHEGDDFGKLALVNDAPRAAS 435 G + +GEEG++++I+ KG V V +G ++ TL +G+ FG+ AL++D R+A+ Sbjct: 44 GDYIIREGEEGSTFFILAKGKVKVTQSTEGHDQPQLIKTLQKGEYFGEKALISDDVRSAN 103 Query: 436 IVLREDNCHFLRVDKEDFNRILRDVE 461 I+ E++ L +D+E FN+ + E Sbjct: 104 IIAEENDVACLVIDRETFNQTVGTFE 129 Score = 42.7 bits (99), Expect = 9e-04, Method: Composition-based stats. Identities = 35/127 (27%), Positives = 62/127 (48%), Gaps = 6/127 (4%) Query: 38 LKGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSS 97 L+ V + + L +I C E +KG + R+G+ G+ ++ + G + V S T Sbjct: 15 LRSVSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQS-TEG 73 Query: 98 HQDAVTICTLGIGTAFGE-SILDNTPRHATIVTRESS-ELLRIEQEDFK---ALWEKYRQ 152 H I TL G FGE +++ + R A I+ E+ L I++E F +E+ ++ Sbjct: 74 HDQPQLIKTLQKGEYFGEKALISDDVRSANIIAEENDVACLVIDRETFNQTVGTFEELQK 133 Query: 153 YMAGLLA 159 Y+ G +A Sbjct: 134 YLEGYVA 140 >6AXF-A nrPDB Length = 397 Score = 54.3 bits (129), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 39/164 (23%), Positives = 73/164 (44%), Gaps = 2/164 (1%) Query: 768 FELMSSKDLAYQMTTYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWV 827 F+ + +LA +T ++ F + L YH+F H L+ F+ FN + WV Sbjct: 153 FDHLEPMELAEHLTYLEYRSFCKI--LFQDYHSFVTHGCTVDNPVLERFISLFNSVSQWV 210 Query: 828 VTEVCLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPS 887 + +R ++ F+ +A + +N N+ A+V GLS+ ++SRL T + Sbjct: 211 QLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLMAVVGGLSHSSISRLKETHSHVSP 270 Query: 888 KFKKFYAEFESLMDPSRNHRAYRLTAAKLEPPLIPFMPLLIKDM 931 + K + L+ + N+ YR A P + + +KD+ Sbjct: 271 ETIKLWEGLTELVTATGNYGNYRRRLAACVGFRFPILGVHLKDL 314 >6BYS-B nrPDB Length = 379 Score = 54.3 bits (129), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 31/101 (30%), Positives = 56/101 (55%), Gaps = 3/101 (2%) Query: 357 LSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLH 416 SHL + ++ + S G TV+ QG+EG ++Y+I +G ++V + + ++ Sbjct: 136 FSHLDDNERSDIFDAMFPVSFIAGETVI-QQGDEGDNFYVIDQGEMDVYVNNEWAT-SVG 193 Query: 417 EGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRIL 457 EG FG+LAL+ PRAA++ + N +D++ + RIL Sbjct: 194 EGGSFGELALIYGTPRAATVKAK-TNVKLWGIDRDSYRRIL 233 Score = 43.9 bits (102), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 24/81 (29%), Positives = 47/81 (58%), Gaps = 8/81 (9%) Query: 67 GITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGE-SILDNTPRHA 125 G T+ +QGD G N+Y + G +DV V+ + ++G G +FGE +++ TPR A Sbjct: 159 GETVIQQGDEGDNFYVIDQGEMDVYVNNEWA-------TSVGEGGSFGELALIYGTPRAA 211 Query: 126 TIVTRESSELLRIEQEDFKAL 146 T+ + + +L I+++ ++ + Sbjct: 212 TVKAKTNVKLWGIDRDSYRRI 232 Score = 42.0 bits (97), Expect = 0.001, Method: Compositional matrix adjust. Identities = 28/82 (34%), Positives = 44/82 (53%), Gaps = 6/82 (7%) Query: 381 GTVLFNQGEEGTSWYIILKGSVNVVIYGKG-----VVCTLHEGDDFGKLALVNDAPRAAS 435 G + QGE G ++IIL+GS V+ V L D FG++AL+ + PRAA+ Sbjct: 277 GQKIVVQGEPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAAT 336 Query: 436 IVLREDNCHFLRVDKEDFNRIL 457 +V R +++D+ F R+L Sbjct: 337 VVAR-GPLKCVKLDRPRFERVL 357 Score = 41.2 bits (95), Expect = 0.003, Method: Compositional matrix adjust. Identities = 25/82 (30%), Positives = 45/82 (54%), Gaps = 2/82 (2%) Query: 64 LEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGE-SILDNTP 122 E G + QG+ G ++ +L GS V + S +++ V + LG FGE ++L N P Sbjct: 274 FEDGQKIVVQGEPGDEFFIILEGSAAV-LQRRSENEEFVEVGRLGPSDYFGEIALLMNRP 332 Query: 123 RHATIVTRESSELLRIEQEDFK 144 R AT+V R + +++++ F+ Sbjct: 333 RAATVVARGPLKCVKLDRPRFE 354 >6CJQ-A nrPDB Length = 456 Score = 53.5 bits (127), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 38/104 (36%), Positives = 52/104 (50%), Gaps = 9/104 (8%) Query: 381 GTVLFNQGEEGTSWYIILKGSVNVVIYG-KGVVCTLHEGDDFGKLALVNDAPRAASIVLR 439 G + GE G+ Y I +GSV V+ K L EG FG++AL+ APR A++ R Sbjct: 344 GEYIIRAGEMGSDVYFINRGSVEVLSADEKTRYAILSEGQFFGEMALILRAPRTATVRAR 403 Query: 440 EDNCHFLRVDKEDFNRILR-------DVEANTVRLKEHDQDVLV 476 C R+DKE F+RIL ++ VR KE + LV Sbjct: 404 A-FCDLYRLDKETFDRILSRYPEIAAQIQELAVRRKELESSGLV 446 Score = 38.1 bits (87), Expect = 0.022, Method: Compositional matrix adjust. Identities = 25/90 (27%), Positives = 45/90 (50%), Gaps = 6/90 (6%) Query: 67 GITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGE-SILDNTPRHA 125 G + R G++G++ Y + GS++V S + L G FGE +++ PR A Sbjct: 344 GEYIIRAGEMGSDVYFINRGSVEVL-----SADEKTRYAILSEGQFFGEMALILRAPRTA 398 Query: 126 TIVTRESSELLRIEQEDFKALWEKYRQYMA 155 T+ R +L R+++E F + +Y + A Sbjct: 399 TVRARAFCDLYRLDKETFDRILSRYPEIAA 428 >5CM8-A nrPDB Length = 473 Score = 53.1 bits (126), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 46/215 (21%), Positives = 91/215 (42%), Gaps = 38/215 (17%) Query: 776 LAYQMTTYDWELFNCVHELELIYHTFG---RHNFKKTTANLDLFLRRFNEIQFWVVTEVC 832 LA Q+T D ELF + + + +G R ++ + +FN++ VV+ V Sbjct: 206 LAEQLTLLDAELFLNLIPSQCLGGLWGHRDRPGHSHLCPSVRATVTQFNKVAGAVVSSVL 265 Query: 833 LCSQLS--------------KRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRL 878 + + +R +LL+K+I++A C+ +N +S +A+V L + + RL Sbjct: 266 GATSIGEGPREVTVRPLRPPQRARLLEKWIRVAEECRLLRNFSSVYAVVSALQSSPIHRL 325 Query: 879 ALTWEKLPSKFKKFYAEFESLMDPSRNHRAYR--LTA-AKLEPP---------------- 919 W + + ++ + N+ R LT K +PP Sbjct: 326 RAAWGETTRDSLRVFSSLCQIFSEEDNYSQSRELLTQEVKPQPPVEPHSKKAPRSGFRGG 385 Query: 920 -LIPFMPLLIKDMTFTHEGNKTFIDN-LVNFEKMR 952 ++P++ +KD+ +K ++N +NF+K R Sbjct: 386 GVVPYLGTFLKDLVMLDAASKDELENGYINFDKRR 420 >2QCS-B nrPDB Length = 291 Score = 53.1 bits (126), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 31/101 (30%), Positives = 56/101 (55%), Gaps = 3/101 (2%) Query: 357 LSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLH 416 SHL + ++ + S G TV+ QG+EG ++Y+I +G ++V + + ++ Sbjct: 47 FSHLDDNERSDIFDAMFPVSFIAGETVI-QQGDEGDNFYVIDQGEMDVYVNNE-WATSVG 104 Query: 417 EGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRIL 457 EG FG+LAL+ PRAA++ + N +D++ + RIL Sbjct: 105 EGGSFGELALIYGTPRAATVKAKT-NVKLWGIDRDSYRRIL 144 Score = 43.5 bits (101), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 24/81 (29%), Positives = 47/81 (58%), Gaps = 8/81 (9%) Query: 67 GITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGE-SILDNTPRHA 125 G T+ +QGD G N+Y + G +DV V+ + ++G G +FGE +++ TPR A Sbjct: 70 GETVIQQGDEGDNFYVIDQGEMDVYVNNEWA-------TSVGEGGSFGELALIYGTPRAA 122 Query: 126 TIVTRESSELLRIEQEDFKAL 146 T+ + + +L I+++ ++ + Sbjct: 123 TVKAKTNVKLWGIDRDSYRRI 143 Score = 38.9 bits (89), Expect = 0.010, Method: Compositional matrix adjust. Identities = 27/82 (32%), Positives = 44/82 (53%), Gaps = 6/82 (7%) Query: 381 GTVLFNQGEEGTSWYIILKGSVNVVIYGKG-----VVCTLHEGDDFGKLALVNDAPRAAS 435 G + QGE G ++IIL+GS V+ V L D FG++AL+ + P+AA+ Sbjct: 188 GQKIVVQGEPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPKAAT 247 Query: 436 IVLREDNCHFLRVDKEDFNRIL 457 +V R +++D+ F R+L Sbjct: 248 VVAR-GPLKCVKLDRPRFERVL 268 Score = 38.5 bits (88), Expect = 0.013, Method: Compositional matrix adjust. Identities = 24/82 (29%), Positives = 45/82 (54%), Gaps = 2/82 (2%) Query: 64 LEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGE-SILDNTP 122 E G + QG+ G ++ +L GS V + S +++ V + LG FGE ++L N P Sbjct: 185 FEDGQKIVVQGEPGDEFFIILEGSAAV-LQRRSENEEFVEVGRLGPSDYFGEIALLMNRP 243 Query: 123 RHATIVTRESSELLRIEQEDFK 144 + AT+V R + +++++ F+ Sbjct: 244 KAATVVARGPLKCVKLDRPRFE 265 >5DYK-A nrPDB Length = 853 Score = 52.0 bits (123), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 33/122 (27%), Positives = 63/122 (51%), Gaps = 8/122 (6%) Query: 25 ERSSEDVDIIFTRLKGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVL 84 E+ SED+D+I T LK + N + + + + G + +QG+ G+ ++ + Sbjct: 40 EKLSEDIDMIKTSLKNNLVCSTLNDNEILTLSNYMQFFVFKSGNLVIKQGEKGSYFFIIN 99 Query: 85 AGSLDVKVSETSSHQDAVTICTLGIGTAFGES-ILDNTPRHATIVTRESSELLRIEQEDF 143 +G DV V++ + T+G G++FGE+ ++ NT R ATI+ L +++ F Sbjct: 100 SGKFDVYVNDKK-------VKTMGKGSSFGEAALIHNTQRSATIIAETDGTLWGVQRSTF 152 Query: 144 KA 145 +A Sbjct: 153 RA 154 Score = 48.9 bits (115), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 29/78 (37%), Positives = 45/78 (57%), Gaps = 1/78 (1%) Query: 381 GTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLRE 440 G + +GE G+ +YII G V +V K + TL + D FG+ AL+ D PR AS++ + Sbjct: 442 GDYIIQEGEVGSRFYIIKNGEVEIV-KNKKRLRTLGKNDYFGERALLYDEPRTASVISKV 500 Query: 441 DNCHFLRVDKEDFNRILR 458 +N VDK F +I++ Sbjct: 501 NNVECWFVDKSVFLQIIQ 518 Score = 45.1 bits (105), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 22/63 (34%), Positives = 39/63 (61%), Gaps = 1/63 (1%) Query: 379 KGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVL 438 K G ++ QGE+G+ ++II G +V + K V T+ +G FG+ AL+++ R+A+I+ Sbjct: 80 KSGNLVIKQGEKGSYFFIINSGKFDVYVNDKKVK-TMGKGSSFGEAALIHNTQRSATIIA 138 Query: 439 RED 441 D Sbjct: 139 ETD 141 Score = 40.4 bits (93), Expect = 0.004, Method: Compositional matrix adjust. Identities = 22/62 (35%), Positives = 35/62 (56%), Gaps = 1/62 (1%) Query: 379 KGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVL 438 K G + QG+ G YI+ +G V I + + L +G FG+ AL+ D PR+A+I+ Sbjct: 198 KSGETIVKQGDYGDVLYILKEGKATVYINDEEIR-VLEKGSYFGERALLYDEPRSATIIA 256 Query: 439 RE 440 +E Sbjct: 257 KE 258 Score = 37.4 bits (85), Expect = 0.029, Method: Compositional matrix adjust. Identities = 25/87 (28%), Positives = 43/87 (49%), Gaps = 11/87 (12%) Query: 48 HPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTL 107 N++ C+ +N + G T+ +QGD G Y + G V +++ I L Sbjct: 184 QKNMITNACVI---QNFKSGETIVKQGDYGDVLYILKEGKATVYINDEE-------IRVL 233 Query: 108 GIGTAFGE-SILDNTPRHATIVTRESS 133 G+ FGE ++L + PR ATI+ +E + Sbjct: 234 EKGSYFGERALLYDEPRSATIIAKEPT 260 Score = 30.8 bits (68), Expect = 3.5, Method: Compositional matrix adjust. Identities = 16/67 (23%), Positives = 39/67 (58%), Gaps = 8/67 (11%) Query: 65 EKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGE-SILDNTPR 123 E+G + ++G++G+ +Y + G +++ ++ + TLG FGE ++L + PR Sbjct: 440 EEGDYIIQEGEVGSRFYIIKNGEVEIV-------KNKKRLRTLGKNDYFGERALLYDEPR 492 Query: 124 HATIVTR 130 A+++++ Sbjct: 493 TASVISK 499 >6AXG-A nrPDB Length = 418 Score = 50.4 bits (119), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 41/170 (24%), Positives = 73/170 (42%), Gaps = 2/170 (1%) Query: 768 FELMSSKDLAYQMTTYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWV 827 F+ + + +LA +T ++ F + +L ++ + L+ + N + WV Sbjct: 155 FDHLETGELAQHLTYLEFRSFQAITPQDL--RSYVLQGSVRGCPALEGSVGLSNSVSRWV 212 Query: 828 VTEVCLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPS 887 V +R Q+L KFI +A + +N N+ A+ GL + A+SRL + L Sbjct: 213 QVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSP 272 Query: 888 KFKKFYAEFESLMDPSRNHRAYRLTAAKLEPPLIPFMPLLIKDMTFTHEG 937 K E L+ N+ YR T A +P + + +KD+ HE Sbjct: 273 DSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVSLHEA 322 >5J3U-A nrPDB Length = 261 Score = 50.4 bits (119), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 38/118 (32%), Positives = 59/118 (50%), Gaps = 9/118 (7%) Query: 375 ESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKG---VVCTLHEGDDFGKLALVNDAP 431 E + T L +G++G YI+ G +N G VV + GD FG+LAL+ +AP Sbjct: 39 EKKIEASTCLIREGDDGECLYIVQSGELNCSKLIDGEERVVKVVGPGDAFGELALLYNAP 98 Query: 432 RAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHD---QDVLVLEKVPAGNRA 486 RAA+ V C + ++ FN I++D A T R +D + V +L+ + A R Sbjct: 99 RAAT-VTSVSACDLWELGRDTFNAIVKD--AATKRRSMYDSFLKSVHILDGMDAYERG 153 Score = 46.6 bits (109), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 36/121 (29%), Positives = 61/121 (50%), Gaps = 8/121 (6%) Query: 347 IYDELLH-IKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGS-VNV 404 +YD L + L + + ++A L E G ++ QGE G +YI+ +GS V Sbjct: 133 MYDSFLKSVHILDGMDAYERGKVADALRTEMFTDGAYIV-RQGELGDVFYIVEEGSAVAT 191 Query: 405 VIYGKGV----VCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDV 460 +G G V GD FG+LAL+N+ PRAA+++ C ++++ F R++ V Sbjct: 192 KSFGPGQPPIEVKKYQAGDYFGELALINEEPRAANVIAH-GICKVACLERKSFKRLMGSV 250 Query: 461 E 461 + Sbjct: 251 Q 251 Score = 41.6 bits (96), Expect = 0.002, Method: Compositional matrix adjust. Identities = 30/104 (28%), Positives = 51/104 (49%), Gaps = 4/104 (3%) Query: 44 FEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVT 103 F L + L + +E L R+GD G Y V +G L+ S+ ++ V Sbjct: 22 FNSLDEKDLNTVILAMQEKKIEASTCLIREGDDGECLYIVQSGELNC--SKLIDGEERV- 78 Query: 104 ICTLGIGTAFGE-SILDNTPRHATIVTRESSELLRIEQEDFKAL 146 + +G G AFGE ++L N PR AT+ + + +L + ++ F A+ Sbjct: 79 VKVVGPGDAFGELALLYNAPRAATVTSVSACDLWELGRDTFNAI 122 Score = 33.9 bits (76), Expect = 0.38, Method: Compositional matrix adjust. Identities = 29/111 (26%), Positives = 50/111 (45%), Gaps = 10/111 (9%) Query: 38 LKGVKAFEKFH-PNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETS 96 L G+ A+E+ + LR E G + RQG++G +Y V GS V Sbjct: 144 LDGMDAYERGKVADALRT-------EMFTDGAYIVRQGELGDVFYIVEEGSA-VATKSFG 195 Query: 97 SHQDAVTICTLGIGTAFGE-SILDNTPRHATIVTRESSELLRIEQEDFKAL 146 Q + + G FGE ++++ PR A ++ ++ +E++ FK L Sbjct: 196 PGQPPIEVKKYQAGDYFGELALINEEPRAANVIAHGICKVACLERKSFKRL 246 >5FET-A nrPDB Length = 847 Score = 48.5 bits (114), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 30/78 (38%), Positives = 44/78 (56%), Gaps = 1/78 (1%) Query: 381 GTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLRE 440 G + +GE G+ +YII G V V GK + TL + D FG+ AL+ D PR ASI+ + Sbjct: 436 GDYIIQEGEVGSRFYIIKNGEVEVTKNGKRLR-TLGKNDYFGERALLYDEPRTASIISKA 494 Query: 441 DNCHFLRVDKEDFNRILR 458 + VDK F +I++ Sbjct: 495 TSVECWFVDKSVFLQIIQ 512 Score = 45.4 bits (106), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 30/122 (24%), Positives = 62/122 (50%), Gaps = 8/122 (6%) Query: 25 ERSSEDVDIIFTRLKGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVL 84 E+ SED+++I LK + N + + + + G + +QG+ G+ ++ + Sbjct: 34 EKLSEDIEMIKASLKNNLVCSTLNDNEILTLSNYMQFFVFKGGDLVIKQGEKGSYFFIIN 93 Query: 85 AGSLDVKVSETSSHQDAVTICTLGIGTAFGES-ILDNTPRHATIVTRESSELLRIEQEDF 143 +G DV V++ + ++G G++FGE+ ++ NT R ATI+ L +++ F Sbjct: 94 SGKFDVYVNDKK-------VKSMGKGSSFGEAALIHNTQRSATIMAETDGTLWGVQRSTF 146 Query: 144 KA 145 +A Sbjct: 147 RA 148 Score = 45.1 bits (105), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 22/63 (34%), Positives = 40/63 (63%), Gaps = 1/63 (1%) Query: 379 KGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVL 438 KGG ++ QGE+G+ ++II G +V + K V ++ +G FG+ AL+++ R+A+I+ Sbjct: 74 KGGDLVIKQGEKGSYFFIINSGKFDVYVNDKKVK-SMGKGSSFGEAALIHNTQRSATIMA 132 Query: 439 RED 441 D Sbjct: 133 ETD 135 Score = 40.0 bits (92), Expect = 0.005, Method: Compositional matrix adjust. Identities = 22/62 (35%), Positives = 36/62 (58%), Gaps = 1/62 (1%) Query: 379 KGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVL 438 K G + QG+ G +I+ +G V I K + L++G FG+ AL+ D PR+A+I+ Sbjct: 192 KPGETIVKQGDYGDVLFILKEGKATVFINDKEIR-VLNKGSYFGERALLYDEPRSATIIA 250 Query: 439 RE 440 +E Sbjct: 251 KE 252 Score = 34.7 bits (78), Expect = 0.22, Method: Compositional matrix adjust. Identities = 19/70 (27%), Positives = 41/70 (58%), Gaps = 8/70 (11%) Query: 65 EKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGE-SILDNTPR 123 E+G + ++G++G+ +Y + G ++V ++ + TLG FGE ++L + PR Sbjct: 434 EEGDYIIQEGEVGSRFYIIKNGEVEVT-------KNGKRLRTLGKNDYFGERALLYDEPR 486 Query: 124 HATIVTRESS 133 A+I+++ +S Sbjct: 487 TASIISKATS 496 >3J4Q-B nrPDB Length = 402 Score = 48.1 bits (113), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 34/97 (35%), Positives = 48/97 (49%), Gaps = 12/97 (12%) Query: 372 LIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGV-----------VCTLHEGDD 420 +I E K G + QGE+ S+YII G V+++I K + H+G Sbjct: 274 VIGEKIYKDGERIIAQGEKADSFYIIESGEVSILIRSKTKSNKNGGNQEVEIAHCHKGQY 333 Query: 421 FGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRIL 457 FG+LALV + PRAAS D L +D + F R+L Sbjct: 334 FGELALVTNKPRAASAYAVGD-VKCLVMDVQAFERLL 369 Score = 45.1 bits (105), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 27/98 (27%), Positives = 57/98 (58%), Gaps = 6/98 (6%) Query: 365 KRELAGVL--IFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDD-- 420 + +L+ VL +FE K + +QG++G ++Y+I +G+ ++++ ++ + D+ Sbjct: 143 QEQLSQVLDAMFEKIVKTDEHVIDQGDDGDNFYVIERGTYDILVTKDNQTRSVGQYDNRG 202 Query: 421 -FGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRIL 457 FG+LAL+ + PRAA+I+ + +D+ F RI+ Sbjct: 203 SFGELALMYNTPRAATIIATSEGS-LWGLDRVTFRRII 239 Score = 37.7 bits (86), Expect = 0.022, Method: Compositional matrix adjust. Identities = 23/78 (29%), Positives = 41/78 (52%), Gaps = 4/78 (5%) Query: 73 QGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGE-SILDNTPRHATIVTRE 131 QGD G N+Y + G+ D+ V++ + + G +FGE +++ NTPR ATI+ Sbjct: 167 QGDDGDNFYVIERGTYDILVTKDNQTRSVGQYDNRG---SFGELALMYNTPRAATIIATS 223 Query: 132 SSELLRIEQEDFKALWEK 149 L +++ F+ + K Sbjct: 224 EGSLWGLDRVTFRRIIVK 241 >4EV0-A nrPDB Length = 216 Score = 48.1 bits (113), Expect = 2e-05, Method: Composition-based stats. Identities = 32/82 (39%), Positives = 45/82 (54%), Gaps = 3/82 (3%) Query: 66 KGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGE-SILDNTPRH 124 +G +F QGD+G Y V +G V++ T T+ LG G FGE S+LD R Sbjct: 29 QGKPIFYQGDLGQALYLVASGK--VRLFRTHLGGQERTLALLGPGELFGEMSLLDEGERS 86 Query: 125 ATIVTRESSELLRIEQEDFKAL 146 A+ V E +ELL + +ED+ AL Sbjct: 87 ASAVAVEDTELLALFREDYLAL 108 Score = 37.0 bits (84), Expect = 0.039, Method: Composition-based stats. Identities = 24/82 (29%), Positives = 44/82 (53%), Gaps = 5/82 (6%) Query: 381 GTVLFNQGEEGTSWYIILKGSVNVVIYGKG----VVCTLHEGDDFGKLALVNDAPRAASI 436 G +F QG+ G + Y++ G V + G + L G+ FG+++L+++ R+AS Sbjct: 30 GKPIFYQGDLGQALYLVASGKVRLFRTHLGGQERTLALLGPGELFGEMSLLDEGERSASA 89 Query: 437 VLREDNCHFLRVDKEDFNRILR 458 V ED L + +ED+ ++R Sbjct: 90 VAVEDT-ELLALFREDYLALIR 110 >4Z07-A nrPDB Length = 262 Score = 47.0 bits (110), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 36/125 (28%), Positives = 63/125 (50%), Gaps = 17/125 (13%) Query: 47 FHPNL----LRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAV 102 F NL +++I C Y K + ++GD+G+ Y + G ++V ++ V Sbjct: 29 FMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVT-------KEGV 81 Query: 103 TICTLGIGTAFGE-SILDNTPRHATIVTRESSELLRIEQEDFKALWE-----KYRQYMAG 156 +CT+G G FGE +IL N R AT+ T + +L I+++ F+ + K+ +YM Sbjct: 82 KLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEF 141 Query: 157 LLAPP 161 L + P Sbjct: 142 LKSVP 146 Score = 45.1 bits (105), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 33/110 (30%), Positives = 53/110 (48%), Gaps = 2/110 (1%) Query: 38 LKGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSS 97 LK V F+ +L ++ + E G + RQG G ++ + G+++V E S Sbjct: 142 LKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTVNV-TREDSP 200 Query: 98 HQDAVTICTLGIGTAFGESILDNTP-RHATIVTRESSELLRIEQEDFKAL 146 +D V + TLG G FGE L R A ++ E+ L I+++ FK L Sbjct: 201 SEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVTCLVIDRDSFKHL 250 Score = 41.6 bits (96), Expect = 0.002, Method: Compositional matrix adjust. Identities = 34/117 (29%), Positives = 58/117 (49%), Gaps = 17/117 (14%) Query: 351 LLHIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVV----- 405 L + L + +LA VL E+H + G + QG G +++II KG+VNV Sbjct: 142 LKSVPTFQSLPEEILSKLADVL-EETHYENGEYIIRQGARGDTFFIISKGTVNVTREDSP 200 Query: 406 ----IYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLRED-NCHFLRVDKEDFNRIL 457 ++ + TL +GD FG+ AL + R A+++ E C L +D++ F ++ Sbjct: 201 SEDPVFLR----TLGKGDWFGEKALQGEDVRTANVIAAEAVTC--LVIDRDSFKHLI 251 Score = 33.1 bits (74), Expect = 0.71, Method: Compositional matrix adjust. Identities = 20/76 (26%), Positives = 39/76 (51%), Gaps = 2/76 (2%) Query: 382 TVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLRED 441 + + +G+ G+ Y++ G V V G + CT+ G FG+LA++ + R A++ Sbjct: 54 SCIIKEGDVGSLVYVMEDGKVEVTKEGVKL-CTMGPGKVFGELAILYNCTRTATVKTLV- 111 Query: 442 NCHFLRVDKEDFNRIL 457 N +D++ F I+ Sbjct: 112 NVKLWAIDRQCFQTIM 127 >3SHR-A nrPDB Length = 299 Score = 47.0 bits (110), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 36/125 (28%), Positives = 63/125 (50%), Gaps = 17/125 (13%) Query: 47 FHPNL----LRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAV 102 F NL +++I C Y K + ++GD+G+ Y + G ++V ++ V Sbjct: 46 FMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVT-------KEGV 98 Query: 103 TICTLGIGTAFGE-SILDNTPRHATIVTRESSELLRIEQEDFKALWE-----KYRQYMAG 156 +CT+G G FGE +IL N R AT+ T + +L I+++ F+ + K+ +YM Sbjct: 99 KLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEF 158 Query: 157 LLAPP 161 L + P Sbjct: 159 LKSVP 163 Score = 44.7 bits (104), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 33/110 (30%), Positives = 53/110 (48%), Gaps = 2/110 (1%) Query: 38 LKGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSS 97 LK V F+ +L ++ + E G + RQG G ++ + G ++V E S Sbjct: 159 LKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGKVNV-TREDSP 217 Query: 98 HQDAVTICTLGIGTAFGESILDNTP-RHATIVTRESSELLRIEQEDFKAL 146 ++D V + TLG G FGE L R A ++ E+ L I+++ FK L Sbjct: 218 NEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVTCLVIDRDSFKHL 267 Score = 40.4 bits (93), Expect = 0.004, Method: Compositional matrix adjust. Identities = 34/117 (29%), Positives = 57/117 (48%), Gaps = 17/117 (14%) Query: 351 LLHIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVV----- 405 L + L + +LA VL E+H + G + QG G +++II KG VNV Sbjct: 159 LKSVPTFQSLPEEILSKLADVL-EETHYENGEYIIRQGARGDTFFIISKGKVNVTREDSP 217 Query: 406 ----IYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLRED-NCHFLRVDKEDFNRIL 457 ++ + TL +GD FG+ AL + R A+++ E C L +D++ F ++ Sbjct: 218 NEDPVFLR----TLGKGDWFGEKALQGEDVRTANVIAAEAVTC--LVIDRDSFKHLI 268 Score = 32.3 bits (72), Expect = 1.1, Method: Compositional matrix adjust. Identities = 20/76 (26%), Positives = 39/76 (51%), Gaps = 2/76 (2%) Query: 382 TVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLRED 441 + + +G+ G+ Y++ G V V G + CT+ G FG+LA++ + R A++ Sbjct: 71 SCIIKEGDVGSLVYVMEDGKVEVTKEGVKL-CTMGPGKVFGELAILYNCTRTATVKTLV- 128 Query: 442 NCHFLRVDKEDFNRIL 457 N +D++ F I+ Sbjct: 129 NVKLWAIDRQCFQTIM 144 >2QVS-B nrPDB Length = 310 Score = 46.6 bits (109), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 34/97 (35%), Positives = 48/97 (49%), Gaps = 12/97 (12%) Query: 372 LIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGV-----------VCTLHEGDD 420 +I E K G + QGE+ S+YII G V+++I K + H+G Sbjct: 182 VIGEKIYKDGERIIAQGEKADSFYIIESGEVSILIRSKTKSNKNGGNQEVEIAHCHKGQY 241 Query: 421 FGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRIL 457 FG+LALV + PRAAS D L +D + F R+L Sbjct: 242 FGELALVTNKPRAASAYGVGD-VKCLVMDVQAFERLL 277 Score = 43.9 bits (102), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 27/98 (27%), Positives = 57/98 (58%), Gaps = 6/98 (6%) Query: 365 KRELAGVL--IFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDD-- 420 + +L+ VL +FE K + +QG++G ++Y+I +G+ ++++ ++ + D+ Sbjct: 51 QEQLSQVLDAMFEKIVKTDEHVIDQGDDGDNFYVIERGTYDILVTKDNQTRSVGQYDNRG 110 Query: 421 -FGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRIL 457 FG+LAL+ + PRAA+I+ + +D+ F RI+ Sbjct: 111 SFGELALMYNTPRAATIIATSEG-SLWGLDRVTFRRII 147 Score = 38.1 bits (87), Expect = 0.019, Method: Compositional matrix adjust. Identities = 23/78 (29%), Positives = 41/78 (52%), Gaps = 4/78 (5%) Query: 73 QGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGE-SILDNTPRHATIVTRE 131 QGD G N+Y + G+ D+ V++ + + G +FGE +++ NTPR ATI+ Sbjct: 75 QGDDGDNFYVIERGTYDILVTKDNQTRSVGQYDNRG---SFGELALMYNTPRAATIIATS 131 Query: 132 SSELLRIEQEDFKALWEK 149 L +++ F+ + K Sbjct: 132 EGSLWGLDRVTFRRIIVK 149 >1CX4-A nrPDB Length = 305 Score = 45.4 bits (106), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 40/138 (28%), Positives = 70/138 (50%), Gaps = 14/138 (10%) Query: 325 DAHMRMILRKPPGQRTVDDLEIIYDELLHIKALSHLSTTVKRELAGVL--IFESHAKGGT 382 DA R+I K QR + L+ ++L K L +++ VL +FE K G Sbjct: 15 DAESRIIHPKTDDQR--NRLQEACKDILLFKNLD------PEQMSQVLDAMFEKLVKEGE 66 Query: 383 VLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDD---FGKLALVNDAPRAASIVLR 439 + +QG++G ++Y+I +G+ ++ + GV + D+ FG+LAL+ + PRAA+I Sbjct: 67 HVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITAT 126 Query: 440 EDNCHFLRVDKEDFNRIL 457 +D+ F RI+ Sbjct: 127 SPGA-LWGLDRVTFRRII 143 Score = 40.8 bits (94), Expect = 0.003, Method: Compositional matrix adjust. Identities = 30/114 (26%), Positives = 53/114 (46%), Gaps = 8/114 (7%) Query: 39 KGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSH 98 K + F+ P + Q+ + + +++G + QGD G N+Y + G+ D+ V Sbjct: 37 KDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIYV-----K 91 Query: 99 QDAVTICTLGIGT--AFGE-SILDNTPRHATIVTRESSELLRIEQEDFKALWEK 149 D V C +FGE +++ NTPR ATI L +++ F+ + K Sbjct: 92 CDGVGRCVGNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFRRIIVK 145 Score = 35.8 bits (81), Expect = 0.095, Method: Compositional matrix adjust. Identities = 27/88 (30%), Positives = 41/88 (46%), Gaps = 13/88 (14%) Query: 381 GTVLFNQGEEGTSWYIILKGSVNVVIYGKGV----------VCTLHEGDDFGKLALVNDA 430 G + QG+ S++I+ G V + + KG + G FG+LALV + Sbjct: 187 GEQIIAQGDSADSFFIVESGEVRITMKRKGKSDIEENGAVEIARCLRGQYFGELALVTNK 246 Query: 431 PRAASI-VLREDNCHFLRVDKEDFNRIL 457 PRAAS + C L +D + F R+L Sbjct: 247 PRAASAHAIGTVKC--LAMDVQAFERLL 272 >5JAX-A nrPDB Length = 135 Score = 45.1 bits (105), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 33/110 (30%), Positives = 53/110 (48%), Gaps = 2/110 (1%) Query: 38 LKGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSS 97 LK V F+ +L ++ + E G + RQG G ++ + G+++V E S Sbjct: 15 LKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTVNV-TREDSP 73 Query: 98 HQDAVTICTLGIGTAFGESILDNTP-RHATIVTRESSELLRIEQEDFKAL 146 +D V + TLG G FGE L R A ++ E+ L I+++ FK L Sbjct: 74 SEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVTCLVIDRDSFKHL 123 Score = 41.2 bits (95), Expect = 0.002, Method: Compositional matrix adjust. Identities = 34/113 (30%), Positives = 56/113 (49%), Gaps = 9/113 (7%) Query: 351 LLHIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKG 410 L + L + +LA VL E+H + G + QG G +++II KG+VNV Sbjct: 15 LKSVPTFQSLPEEILSKLADVLE-ETHYENGEYIIRQGARGDTFFIISKGTVNVTREDSP 73 Query: 411 -----VVCTLHEGDDFGKLALVNDAPRAASIVLRED-NCHFLRVDKEDFNRIL 457 + TL +GD FG+ AL + R A+++ E C L +D++ F ++ Sbjct: 74 SEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVTC--LVIDRDSFKHLI 124 >4QX5-A nrPDB Length = 153 Score = 45.1 bits (105), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 33/110 (30%), Positives = 53/110 (48%), Gaps = 2/110 (1%) Query: 38 LKGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSS 97 LK V F+ +L ++ + E G + RQG G ++ + G+++V E S Sbjct: 15 LKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTVNV-TREDSP 73 Query: 98 HQDAVTICTLGIGTAFGESILDNTP-RHATIVTRESSELLRIEQEDFKAL 146 +D V + TLG G FGE L R A ++ E+ L I+++ FK L Sbjct: 74 SEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVTCLVIDRDSFKHL 123 Score = 41.6 bits (96), Expect = 0.002, Method: Compositional matrix adjust. Identities = 34/113 (30%), Positives = 56/113 (49%), Gaps = 9/113 (7%) Query: 351 LLHIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKG 410 L + L + +LA VL E+H + G + QG G +++II KG+VNV Sbjct: 15 LKSVPTFQSLPEEILSKLADVLE-ETHYENGEYIIRQGARGDTFFIISKGTVNVTREDSP 73 Query: 411 -----VVCTLHEGDDFGKLALVNDAPRAASIVLRED-NCHFLRVDKEDFNRIL 457 + TL +GD FG+ AL + R A+++ E C L +D++ F ++ Sbjct: 74 SEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVTC--LVIDRDSFKHLI 124 >4X6Q-B nrPDB Length = 416 Score = 44.7 bits (104), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 39/138 (28%), Positives = 70/138 (50%), Gaps = 14/138 (10%) Query: 325 DAHMRMILRKPPGQRTVDDLEIIYDELLHIKALSHLSTTVKRELAGVL--IFESHAKGGT 382 DA R+I K QR + L+ ++L K L +++ VL +FE K G Sbjct: 126 DAESRIIHPKTDDQR--NRLQEACKDILLFKNLD------PEQMSQVLDAMFEKLVKEGE 177 Query: 383 VLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDD---FGKLALVNDAPRAASIVLR 439 + +QG++G ++Y+I +G+ ++ + GV + D+ FG+LAL+ + P+AA+I Sbjct: 178 HVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPKAATITAT 237 Query: 440 EDNCHFLRVDKEDFNRIL 457 +D+ F RI+ Sbjct: 238 SPGA-LWGLDRVTFRRII 254 Score = 39.7 bits (91), Expect = 0.007, Method: Compositional matrix adjust. Identities = 28/111 (25%), Positives = 52/111 (46%), Gaps = 8/111 (7%) Query: 39 KGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSH 98 K + F+ P + Q+ + + +++G + QGD G N+Y + G+ D+ V Sbjct: 148 KDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIYVK----- 202 Query: 99 QDAVTICTLGIGT--AFGE-SILDNTPRHATIVTRESSELLRIEQEDFKAL 146 D V C +FGE +++ NTP+ ATI L +++ F+ + Sbjct: 203 CDGVGRCVGNYDNRGSFGELALMYNTPKAATITATSPGALWGLDRVTFRRI 253 Score = 36.6 bits (83), Expect = 0.059, Method: Compositional matrix adjust. Identities = 29/95 (30%), Positives = 44/95 (46%), Gaps = 20/95 (21%) Query: 381 GTVLFNQGEE-------GTSWYIILKGSVNVVIYGKGV----------VCTLHEGDDFGK 423 GT ++N GE+ S++I+ G V + + KG + G FG+ Sbjct: 291 GTKVYNDGEQIIAQGDLADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCFRGQYFGE 350 Query: 424 LALVNDAPRAASI-VLREDNCHFLRVDKEDFNRIL 457 LALV + PRAAS + C L +D + F R+L Sbjct: 351 LALVTNKPRAASAHAIGTVKC--LAMDVQAFERLL 383 >4CHV-A nrPDB Length = 361 Score = 41.2 bits (95), Expect = 0.002, Method: Compositional matrix adjust. Identities = 29/110 (26%), Positives = 46/110 (41%), Gaps = 10/110 (9%) Query: 38 LKGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSS 97 + V F+K P +L +I + G + R G+ G + V+ GS+ V Sbjct: 230 VAAVPLFQKLGPAVLVEIVRALRARTVPAGAVICRIGEPGDRMFFVVEGSVSVATPNP-- 287 Query: 98 HQDAVTICTLGIGTAFGE-SILDNTPRHATIVTRESSELLRIEQEDFKAL 146 LG G FGE +++ PR AT+ + LL + DF+ L Sbjct: 288 -------VELGPGAFFGEMALISGEPRSATVSAATTVSLLSLHSADFQML 330 Score = 34.3 bits (77), Expect = 0.31, Method: Compositional matrix adjust. Identities = 22/76 (28%), Positives = 36/76 (47%), Gaps = 4/76 (5%) Query: 381 GTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLRE 440 G V+ GE G + +++GSV+V L G FG++AL++ PR+A+ V Sbjct: 259 GAVICRIGEPGDRMFFVVEGSVSVATPNP---VELGPGAFFGEMALISGEPRSAT-VSAA 314 Query: 441 DNCHFLRVDKEDFNRI 456 L + DF + Sbjct: 315 TTVSLLSLHSADFQML 330 >6FTF-B nrPDB Length = 304 Score = 40.4 bits (93), Expect = 0.004, Method: Compositional matrix adjust. Identities = 29/93 (31%), Positives = 47/93 (50%), Gaps = 9/93 (9%) Query: 351 LLHIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKG 410 L ++ L L + K +LA L E + G ++ + GEEG YII++G+V V+ G+ Sbjct: 160 LANVPFLGGLDSYEKLQLADALSSEEFSPGEYII-HYGEEGEWLYIIMEGTVEVI--GRD 216 Query: 411 V------VCTLHEGDDFGKLALVNDAPRAASIV 437 VC +GD G+L +N+ A +V Sbjct: 217 ADGEPTKVCEFTQGDHIGELEFLNNHRTVADVV 249 Score = 32.7 bits (73), Expect = 0.84, Method: Compositional matrix adjust. Identities = 28/135 (20%), Positives = 58/135 (42%), Gaps = 1/135 (0%) Query: 323 GPDAHMRMILRKPPGQRTVDDLEIIYDELLHIKALSHLSTTVKRELAGVLIFESHAKGGT 382 G D + + P +++ D++ +I L H S L+T + +AG + + Sbjct: 12 GIDPEKAKLYQAPYFEKSEDEMNLITKLLTHNVLFSFLNTKDIKVVAGAMQRATFKHDDC 71 Query: 383 VLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDN 442 ++ YII G +++ G+ V EG G+L L+ D P A++ + D Sbjct: 72 IMEAGQTTCNKLYIIQSGHADIIKEGQKVYLKT-EGTAVGELELMYDTPVVATVKVCTDE 130 Query: 443 CHFLRVDKEDFNRIL 457 +D++ + ++ Sbjct: 131 LIAWVLDRDTYRNLV 145 >4I0B-A nrPDB Length = 222 Score = 40.4 bits (93), Expect = 0.004, Method: Compositional matrix adjust. Identities = 23/81 (28%), Positives = 45/81 (55%), Gaps = 4/81 (4%) Query: 382 TVLFNQGEEGTSWYIILKGSVNVVIY---GKGVVCT-LHEGDDFGKLALVNDAPRAASIV 437 + L +QGE+ + Y I+KGSV V+I GK ++ + L++GD G+L L + ++ V Sbjct: 40 STLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWV 99 Query: 438 LREDNCHFLRVDKEDFNRILR 458 + C + + F ++++ Sbjct: 100 RAKTACEVAEISYKKFRQLIQ 120 >3KCC-A nrPDB Length = 260 Score = 40.4 bits (93), Expect = 0.004, Method: Compositional matrix adjust. Identities = 23/81 (28%), Positives = 45/81 (55%), Gaps = 4/81 (4%) Query: 382 TVLFNQGEEGTSWYIILKGSVNVVIY---GKGVVCT-LHEGDDFGKLALVNDAPRAASIV 437 + L +QGE+ + Y I+KGSV V+I GK ++ + L++GD G+L L + ++ V Sbjct: 78 STLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWV 137 Query: 438 LREDNCHFLRVDKEDFNRILR 458 + C + + F ++++ Sbjct: 138 RAKTACEVAEISYKKFRQLIQ 158 >4CYD-A nrPDB Length = 225 Score = 36.2 bits (82), Expect = 0.066, Method: Compositional matrix adjust. Identities = 18/61 (29%), Positives = 32/61 (52%), Gaps = 4/61 (6%) Query: 381 GTVLFNQGEEGTSWYIILKGSVNVVIYG----KGVVCTLHEGDDFGKLALVNDAPRAASI 436 G +F++GE G YII G V + + + ++ + D FG+L++ + PR +S Sbjct: 35 GATIFDEGEPGDRLYIITSGKVKLARHAPDGRENLLTIMGPSDMFGELSIFDPGPRTSSA 94 Query: 437 V 437 V Sbjct: 95 V 95 >3T6G-A nrPDB Length = 331 Score = 35.8 bits (81), Expect = 0.11, Method: Compositional matrix adjust. Identities = 54/226 (23%), Positives = 88/226 (38%), Gaps = 36/226 (15%) Query: 813 LDLFLRRFNEIQFWVVTEVCLCS-QLSKRVQLLKKFIKIAAHCK-EYKNLNSFFAIVMGL 870 LDL L RF+ + + ++ + +R LL K I++AA + N+ SF A++ L Sbjct: 97 LDL-LERFHTMSIMLAVDILGSTGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGAL 155 Query: 871 SNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTAAKLEPPL--------IP 922 +SRL TW L + + +E + P L K PPL +P Sbjct: 156 DMAQISRLEQTWVTLRQRHTEGAILYEKKLKPFLK----SLNEGKEGPPLSNTTFPHVLP 211 Query: 923 FMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVR-----YYRSQPFNPDAAQAN 977 + LL D + EG + + E + ARTV Y+ + QA Sbjct: 212 LITLLESD-SAPPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGFQAR 270 Query: 978 KNHQDVRSYVRQLNVIDNQ---------------RTLSQMSHRLEP 1008 +V S Q+ ++ + L+ +SH+LEP Sbjct: 271 PELLEVFSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEP 316 >5H3O-A nrPDB Length = 738 Score = 35.4 bits (80), Expect = 0.14, Method: Compositional matrix adjust. Identities = 20/51 (39%), Positives = 30/51 (58%), Gaps = 1/51 (1%) Query: 381 GTVLFNQGEEGTSWYIILKGSVNVVIY-GKGVVCTLHEGDDFGKLALVNDA 430 G + +G+ G YI+ +G + VV GK V TL EG FG+L+++N A Sbjct: 522 GDFICKKGDIGREMYIVKRGRLQVVDDDGKKVFVTLQEGSVFGELSILNIA 572 >1FSH-A nrPDB Length = 105 Score = 34.7 bits (78), Expect = 0.20, Method: Compositional matrix adjust. Identities = 22/83 (26%), Positives = 37/83 (44%), Gaps = 1/83 (1%) Query: 209 ILRIAILSRAPHMIRDRKYHLKTYRQCCVGTELVDWMIQQTSCVHSRTQAVGMWQVLLED 268 I+R+ L + IRDR + T +G ++VDW+ R +A +L+ Sbjct: 24 IVRVMQLPDSGLEIRDRMWLKITIANAVIGADVVDWLYTHVEGFKERREARKYASSMLKH 83 Query: 269 GVLNHVDQERHFQDKYLFYRFLD 291 G L H + F ++ +Y F D Sbjct: 84 GFLRHTVNKITFSEQ-CYYVFGD 105 >1S94-A nrPDB Length = 180 Score = 33.9 bits (76), Expect = 0.33, Method: Compositional matrix adjust. Identities = 23/74 (31%), Positives = 37/74 (50%), Gaps = 5/74 (6%) Query: 583 QWAAMYGDLLQEDDVAMAFLEEFYVSVSDDARMMAAFKEQLPELEKIVKQISEDAKAPQK 642 + AA+ + E+DV EE V V M F EQ+ E+ ++ +IS++ A +K Sbjct: 10 RLAALKAAVSDEEDV-----EEVAVQVDSGGGFMEEFFEQVEEIRAMIDKISDNVDAVKK 64 Query: 643 KHKVLLQQFNTGDE 656 KH +L T D+ Sbjct: 65 KHSDILSAPQTDDQ 78 >3I59-A nrPDB Length = 249 Score = 33.5 bits (75), Expect = 0.54, Method: Compositional matrix adjust. Identities = 17/59 (28%), Positives = 30/59 (50%), Gaps = 4/59 (6%) Query: 381 GTVLFNQGEEGTSWYIILKGSVNVVIYG----KGVVCTLHEGDDFGKLALVNDAPRAAS 435 G +F +GE G YII+ G V + + ++ + D FG+L++ + PR +S Sbjct: 59 GHTVFAEGEPGDRLYIIISGKVKIGRRAPDGRENLLTIMGPSDMFGELSIFDPGPRTSS 117 >1V3F-A nrPDB Length = 120 Score = 32.7 bits (73), Expect = 0.72, Method: Composition-based stats. Identities = 21/64 (32%), Positives = 35/64 (54%), Gaps = 3/64 (4%) Query: 231 TYRQCCVGTELVDWMIQQTSCVHSRTQAVGMWQVLLEDGVLNHVDQERH--FQDKYLFYR 288 TY++ +G+ LVDW+I ++ SR +AV + +L+E+ L V + L + Sbjct: 33 TYKKTFLGSSLVDWLI-SSNFAASRLEAVTLASMLMEENFLRPVGVRSMGAIRSGDLAEQ 91 Query: 289 FLDD 292 FLDD Sbjct: 92 FLDD 95 >3DKW-A nrPDB Length = 227 Score = 32.7 bits (73), Expect = 0.89, Method: Compositional matrix adjust. Identities = 15/53 (28%), Positives = 28/53 (52%) Query: 38 LKGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDV 90 L+ FE P L+++ NL+KG +FRQG+ +Y +++G + + Sbjct: 11 LQSHHLFEPLSPVQLQELLASSDLVNLDKGAYVFRQGEPAHAFYYLISGCVKI 63 >3ML6-A nrPDB Length = 385 Score = 32.0 bits (71), Expect = 1.4, Method: Compositional matrix adjust. Identities = 18/70 (25%), Positives = 33/70 (47%), Gaps = 1/70 (1%) Query: 222 IRDRKYHLKTYRQCCVGTELVDWMIQQTSCVHSRTQAVGMWQVLLEDGVLNHVDQERHFQ 281 +RDR + T +G+++VDW+ R +A LL+ G++ H + F Sbjct: 25 VRDRMWLKITIPNAFLGSDVVDWLYHHVEGFPERREARKYASGLLKAGLIRHTVNKITFS 84 Query: 282 DKYLFYRFLD 291 ++ +Y F D Sbjct: 85 EQ-CYYVFGD 93 >5VA1-A nrPDB Length = 795 Score = 32.0 bits (71), Expect = 1.4, Method: Compositional matrix adjust. Identities = 23/83 (27%), Positives = 40/83 (48%), Gaps = 2/83 (2%) Query: 376 SHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGK-LALVNDAPRAA 434 +HA G L + G+ T+ Y I +GS+ ++ G VV L + D FG+ L L ++ Sbjct: 521 THAPPGDTLVHAGDLLTALYFISRGSIE-ILRGDVVVAILGKNDIFGEPLNLYARPGKSN 579 Query: 435 SIVLREDNCHFLRVDKEDFNRIL 457 V C ++ ++D +L Sbjct: 580 GDVRALTYCDLHKIHRDDLLEVL 602 >2Y6I-A nrPDB Length = 785 Score = 31.2 bits (69), Expect = 2.6, Method: Compositional matrix adjust. Identities = 20/64 (31%), Positives = 30/64 (46%), Gaps = 10/64 (15%) Query: 727 DVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTTGTVG---TFELMSSKDLAYQMTTY 783 DV LT NG + ++ P+ + GP+TG VG F SKD ++ +Y Sbjct: 684 DVVFHGVLTDNGDIS-------NNKAPIAKVTGPSTGAVGRNIEFSGKDSKDEDGKIVSY 736 Query: 784 DWEL 787 DW+ Sbjct: 737 DWDF 740 >5SUY-A nrPDB Length = 97 Score = 30.8 bits (68), Expect = 2.9, Method: Compositional matrix adjust. Identities = 18/70 (25%), Positives = 33/70 (47%), Gaps = 1/70 (1%) Query: 222 IRDRKYHLKTYRQCCVGTELVDWMIQQTSCVHSRTQAVGMWQVLLEDGVLNHVDQERHFQ 281 +RDR + T +G+++VDW+ R +A LL+ G++ H + F Sbjct: 26 VRDRMWLKITIPNAFLGSDVVDWLYHHVEGFPERREARKYASGLLKAGLIRHTVNKITFS 85 Query: 282 DKYLFYRFLD 291 ++ +Y F D Sbjct: 86 EQ-CYYVFGD 94 >3IWZ-A nrPDB Length = 230 Score = 30.8 bits (68), Expect = 3.0, Method: Compositional matrix adjust. Identities = 21/81 (25%), Positives = 36/81 (44%), Gaps = 4/81 (4%) Query: 70 LFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGES--ILDNTPRHATI 127 +FR GD Y V++GS+ + E + + + G G GE +++ R + Sbjct: 45 VFRPGDPAGTLYYVISGSVSIIAEEDDDRE--LVLGYFGSGEFVGEMGLFIESDTREVIL 102 Query: 128 VTRESSELLRIEQEDFKALWE 148 TR EL I E + L++ Sbjct: 103 RTRTQCELAEISYERLQQLFQ 123 >4L11-A nrPDB Length = 204 Score = 30.8 bits (68), Expect = 3.2, Method: Compositional matrix adjust. Identities = 22/76 (28%), Positives = 33/76 (43%), Gaps = 7/76 (9%) Query: 41 VKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQD 100 AFE P LR + L + G L +GD+ T Y + GS+++ +D Sbjct: 77 CSAFEAASPGCLRALSLKFKTTHAPPGDILVHKGDVLTYLYFIARGSIEIL-------KD 129 Query: 101 AVTICTLGIGTAFGES 116 V + LG FGE+ Sbjct: 130 DVVMAILGKDDIFGEN 145 >2N7G-A nrPDB Length = 154 Score = 30.4 bits (67), Expect = 3.9, Method: Compositional matrix adjust. Identities = 23/83 (27%), Positives = 40/83 (48%), Gaps = 2/83 (2%) Query: 376 SHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGK-LALVNDAPRAA 434 +HA G L + G+ T+ Y I +GS+ ++ G VV L + D FG+ L L ++ Sbjct: 51 THAPPGDTLVHAGDLLTALYFISRGSIE-ILRGDVVVAILGKNDIFGEPLNLYARPGKSN 109 Query: 435 SIVLREDNCHFLRVDKEDFNRIL 457 V C ++ ++D +L Sbjct: 110 GDVRALTYCDLHKIHRDDLLEVL 132 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 4F7Z-A nrPDB 1692 0.0 4MGY-E nrPDB 1155 0.0 1O7F-A nrPDB 788 0.0 1XDV-A nrPDB 328 5e-90 5OVF-A nrPDB 328 9e-90 6EIE-A nrPDB 325 6e-89 2IJE-S nrPDB 296 2e-80 4L9M-A nrPDB 261 1e-69 6AXF-A nrPDB 243 3e-64 6AXG-A nrPDB 231 1e-60 3QXL-A nrPDB 219 6e-57 5CM8-A nrPDB 199 6e-51 1CX4-A nrPDB 151 2e-36 4X6Q-B nrPDB 148 1e-35 5KBF-A nrPDB 146 3e-35 2DHZ-A nrPDB 139 6e-33 5DYK-A nrPDB 138 1e-32 1WGY-A nrPDB 136 4e-32 3SHR-A nrPDB 134 1e-31 4Z07-A nrPDB 134 1e-31 2QCS-B nrPDB 133 5e-31 5JAX-A nrPDB 132 5e-31 4QX5-A nrPDB 132 5e-31 5FET-A nrPDB 132 7e-31 2D93-A nrPDB 132 8e-31 6BQ8-A nrPDB 131 1e-30 6BYS-B nrPDB 129 4e-30 4DIN-B nrPDB 129 7e-30 3J4Q-B nrPDB 127 3e-29 2QVS-B nrPDB 126 4e-29 5J3U-A nrPDB 126 4e-29 6CJQ-A nrPDB 114 2e-25 5V4S-A nrPDB 99 7e-21 4EV0-A nrPDB 99 9e-21 Sequences not found previously or not previously below threshold: 6FTF-B nrPDB 73 7e-13 5JON-A nrPDB 71 2e-12 5U6P-A nrPDB 71 3e-12 3I59-A nrPDB 65 1e-10 4CHV-A nrPDB 65 2e-10 4CYD-A nrPDB 63 7e-10 4ORF-A nrPDB 62 1e-09 5H3O-A nrPDB 62 1e-09 3E97-A nrPDB 59 1e-08 3KCC-A nrPDB 55 1e-07 4AVC-A nrPDB 55 1e-07 3UKN-A nrPDB 55 1e-07 4I0B-A nrPDB 55 2e-07 3H3Z-A nrPDB 53 5e-07 2N7G-A nrPDB 53 5e-07 5VA1-A nrPDB 53 8e-07 5K7L-A nrPDB 50 5e-06 4F8A-A nrPDB 50 5e-06 3DKW-A nrPDB 48 2e-05 2OZ6-A nrPDB 48 3e-05 5W5B-A nrPDB 48 3e-05 3T6A-A nrPDB 47 3e-05 3T6G-A nrPDB 46 1e-04 4L11-A nrPDB 45 2e-04 3B02-A nrPDB 43 7e-04 2GAU-A nrPDB 41 0.002 1ZYB-A nrPDB 38 0.020 1S94-A nrPDB 36 0.073 3IWZ-A nrPDB 36 0.075 1FSH-A nrPDB 35 0.11 3WCG-A nrPDB 35 0.13 2ZCW-A nrPDB 35 0.21 5E44-A nrPDB 34 0.27 1V3F-A nrPDB 34 0.35 4CEX-C nrPDB 31 2.2 5SUY-A nrPDB 31 2.2 3ML6-A nrPDB 31 2.2 1T9K-A nrPDB 31 3.3 5V8F-D nrPDB 30 3.5 3LOO-A nrPDB 30 6.7 >4F7Z-A nrPDB Length = 999 Score = 1692 bits (4383), Expect = 0.0, Method: Composition-based stats. Identities = 992/1011 (98%), Positives = 992/1011 (98%), Gaps = 18/1011 (1%) Query: 1 MVAAHAAHSQSSAEWIACLDKRPLERSSEDVDIIFTRLKGVKAFEKFHPNLLRQICLCGY 60 MVAAHAAHSQSSAEWIACLDKRPLERSSEDVDIIFTRLKGVKAFEKFHPNLLRQICLCGY Sbjct: 7 MVAAHAAHSQSSAEWIACLDKRPLERSSEDVDIIFTRLKGVKAFEKFHPNLLRQICLCGY 66 Query: 61 YENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGESILDN 120 YENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGESILDN Sbjct: 67 YENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGESILDN 126 Query: 121 TPRHATIVTRESSELLRIEQEDFKALWEKYRQYMAGLLAPPYGVMETGSNNDRIPDKENT 180 TPRHATIVTRESSELLRIEQEDFKALWEKYRQYMAGLLAPPYGVMETGSNNDRIPDKEN Sbjct: 127 TPRHATIVTRESSELLRIEQEDFKALWEKYRQYMAGLLAPPYGVMETGSNNDRIPDKEN- 185 Query: 181 PLIEPHVPLRPAHTITKVPSEKILRAGKILRIAILSRAPHMIRDRKYHLKTYRQCCVGTE 240 VPSEKILRAGKILRIAILSRAPHMIRDRKYHLKTYRQCCVGTE Sbjct: 186 -----------------VPSEKILRAGKILRIAILSRAPHMIRDRKYHLKTYRQCCVGTE 228 Query: 241 LVDWMIQQTSCVHSRTQAVGMWQVLLEDGVLNHVDQERHFQDKYLFYRFLDDEREDAPLP 300 LVDWMIQQTSCVHSRTQAVGMWQVLLEDGVLNHVDQERHFQDKYLFYRFLDDEREDAPLP Sbjct: 229 LVDWMIQQTSCVHSRTQAVGMWQVLLEDGVLNHVDQERHFQDKYLFYRFLDDEREDAPLP 288 Query: 301 TEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYDELLHIKALSHL 360 TEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYDELLHIKALSHL Sbjct: 289 TEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYDELLHIKALSHL 348 Query: 361 STTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDD 420 STTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDD Sbjct: 349 STTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDD 408 Query: 421 FGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKV 480 FGKLALVNDAPRAASIVLREDNCHFLRVDKED NRILRDVEANTVRLKEHDQDVLVLEKV Sbjct: 409 FGKLALVNDAPRAASIVLREDNCHFLRVDKEDGNRILRDVEANTVRLKEHDQDVLVLEKV 468 Query: 481 PAGNRAANQGNSQPQQKYTVMSGTPEKILEHFLETIRLEPSLNEATDSVLNDFVMMHCVF 540 PAGNRAANQGNSQPQQKYTVMSGTPEKILEHFLETIRLEPSLNEATDSVLNDFVMMHCVF Sbjct: 469 PAGNRAANQGNSQPQQKYTVMSGTPEKILEHFLETIRLEPSLNEATDSVLNDFVMMHCVF 528 Query: 541 MPNTQLCPALVAHYHAQPSQGTEQERMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVAMA 600 MPNTQLCPALVAHYHAQPSQGTEQERMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVAMA Sbjct: 529 MPNTQLCPALVAHYHAQPSQGTEQERMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVAMA 588 Query: 601 FLEEFYVSVSDDARMMAAFKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQK 660 FLEEFYVSVSDDARMMAAFKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQK Sbjct: 589 FLEEFYVSVSDDARMMAAFKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQK 648 Query: 661 RQPIRGSDEVLFKVYCIDHTYTTIRVPVAASVKEVISAVADKLGSGEGLIIVKMNSGGEK 720 RQPIRGSDEVLFKVYCIDHTYTTIRVPVAASVKEVISAVADKLGSGEGLIIVKMNSGGEK Sbjct: 649 RQPIRGSDEVLFKVYCIDHTYTTIRVPVAASVKEVISAVADKLGSGEGLIIVKMNSGGEK 708 Query: 721 VVLKSNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTTGTVGTFELMSSKDLAYQM 780 VVLKSNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTTGTVGTFELMSSKDLAYQM Sbjct: 709 VVLKSNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTTGTVGTFELMSSKDLAYQM 768 Query: 781 TTYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEVCLCSQLSKR 840 TTYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEVCLCSQLSKR Sbjct: 769 TTYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEVCLCSQLSKR 828 Query: 841 VQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLM 900 VQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLM Sbjct: 829 VQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLM 888 Query: 901 DPSRNHRAYRLTAAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTART 960 DPSRNHRAYRLTAAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTART Sbjct: 889 DPSRNHRAYRLTAAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTART 948 Query: 961 VRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP 1011 VRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP Sbjct: 949 VRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP 999 >4MGY-E nrPDB Length = 694 Score = 1155 bits (2987), Expect = 0.0, Method: Composition-based stats. Identities = 687/688 (99%), Positives = 688/688 (100%) Query: 324 PDAHMRMILRKPPGQRTVDDLEIIYDELLHIKALSHLSTTVKRELAGVLIFESHAKGGTV 383 PDAHMRMILRKPPGQRTVDDLEIIYDELLHIKALSHLSTTVKRELAGVLIFESHAKGGTV Sbjct: 7 PDAHMRMILRKPPGQRTVDDLEIIYDELLHIKALSHLSTTVKRELAGVLIFESHAKGGTV 66 Query: 384 LFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNC 443 LFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFG+LALVNDAPRAASIVLREDNC Sbjct: 67 LFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGQLALVNDAPRAASIVLREDNC 126 Query: 444 HFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVPAGNRAANQGNSQPQQKYTVMSG 503 HFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVPAGNRAANQGNSQPQQKYTVMSG Sbjct: 127 HFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVPAGNRAANQGNSQPQQKYTVMSG 186 Query: 504 TPEKILEHFLETIRLEPSLNEATDSVLNDFVMMHCVFMPNTQLCPALVAHYHAQPSQGTE 563 TPEKILEHFLETIRLEPSLNEATDSVLNDFVMMHCVFMPNTQLCPALVAHYHAQPSQGTE Sbjct: 187 TPEKILEHFLETIRLEPSLNEATDSVLNDFVMMHCVFMPNTQLCPALVAHYHAQPSQGTE 246 Query: 564 QERMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVAMAFLEEFYVSVSDDARMMAAFKEQL 623 QERMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVAMAFLEEFYVSVSDDARMMAAFKEQL Sbjct: 247 QERMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVAMAFLEEFYVSVSDDARMMAAFKEQL 306 Query: 624 PELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRGSDEVLFKVYCIDHTYTT 683 PELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRGSDEVLFKVYCIDHTYTT Sbjct: 307 PELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRGSDEVLFKVYCIDHTYTT 366 Query: 684 IRVPVAASVKEVISAVADKLGSGEGLIIVKMNSGGEKVVLKSNDVSVFTTLTINGRLFAC 743 IRVPVAASVKEVISAVADKLGSGEGLIIVKMNSGGEKVVLKSNDVSVFTTLTINGRLFAC Sbjct: 367 IRVPVAASVKEVISAVADKLGSGEGLIIVKMNSGGEKVVLKSNDVSVFTTLTINGRLFAC 426 Query: 744 PREQFDSLTPLPEQEGPTTGTVGTFELMSSKDLAYQMTTYDWELFNCVHELELIYHTFGR 803 PREQFDSLTPLPEQEGPTTGTVGTFELMSSKDLAYQMTTYDWELFNCVHELELIYHTFGR Sbjct: 427 PREQFDSLTPLPEQEGPTTGTVGTFELMSSKDLAYQMTTYDWELFNCVHELELIYHTFGR 486 Query: 804 HNFKKTTANLDLFLRRFNEIQFWVVTEVCLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSF 863 HNFKKTTANLDLFLRRFNEIQFWVVTEVCLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSF Sbjct: 487 HNFKKTTANLDLFLRRFNEIQFWVVTEVCLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSF 546 Query: 864 FAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTAAKLEPPLIPF 923 FAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTAAKLEPPLIPF Sbjct: 547 FAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTAAKLEPPLIPF 606 Query: 924 MPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQDV 983 MPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQDV Sbjct: 607 MPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQDV 666 Query: 984 RSYVRQLNVIDNQRTLSQMSHRLEPRRP 1011 RSYVRQLNVIDNQRTLSQMSHRLEPRRP Sbjct: 667 RSYVRQLNVIDNQRTLSQMSHRLEPRRP 694 Score = 138 bits (347), Expect = 1e-32, Method: Composition-based stats. Identities = 54/189 (28%), Positives = 92/189 (48%), Gaps = 14/189 (7%) Query: 19 LDKRPLERSSEDVDIIFTRLKGVKAFEKFHPNLLRQICLCGYYENLEKGIT-LFRQGDIG 77 L K P +R+ +D++II+ L +KA + R++ +E+ KG T LF QG+ G Sbjct: 15 LRKPPGQRTVDDLEIIYDELLHIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEG 74 Query: 78 TNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGE-SILDNTPRHATIVTRE-SSEL 135 T+WY +L GS++V + +CTL G FG+ +++++ PR A+IV RE + Sbjct: 75 TSWYIILKGSVNVVIYGKG------VVCTLHEGDDFGQLALVNDAPRAASIVLREDNCHF 128 Query: 136 LRIEQEDFKALWEKYRQYMAGLLAPPYGVMETGSNNDRIPDKENTPLIEPHVPLRPAHTI 195 LR+++EDF + L V+ +++P P + + Sbjct: 129 LRVDKEDFNRILRDVEANTVRLKEHDQDVLVL----EKVPAGNRAANQGNSQPQQKYTVM 184 Query: 196 TKVPSEKIL 204 + P EKIL Sbjct: 185 SGTP-EKIL 192 >1O7F-A nrPDB Length = 469 Score = 788 bits (2036), Expect = 0.0, Method: Composition-based stats. Identities = 463/481 (96%), Positives = 463/481 (96%), Gaps = 18/481 (3%) Query: 1 MVAAHAAHSQSSAEWIACLDKRPLERSSEDVDIIFTRLKGVKAFEKFHPNLLRQICLCGY 60 MVAAHAAHSQSSAEWIACLDKRPLERSSEDVDIIFTRLKGVKAFEKFHPNLLRQICLCGY Sbjct: 7 MVAAHAAHSQSSAEWIACLDKRPLERSSEDVDIIFTRLKGVKAFEKFHPNLLRQICLCGY 66 Query: 61 YENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGESILDN 120 YENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGESILDN Sbjct: 67 YENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGESILDN 126 Query: 121 TPRHATIVTRESSELLRIEQEDFKALWEKYRQYMAGLLAPPYGVMETGSNNDRIPDKENT 180 TPRHATIVTRESSELLRIEQEDFKALWEKYRQYMAGLLAPPYGVMETGSNNDRIPDKEN Sbjct: 127 TPRHATIVTRESSELLRIEQEDFKALWEKYRQYMAGLLAPPYGVMETGSNNDRIPDKEN- 185 Query: 181 PLIEPHVPLRPAHTITKVPSEKILRAGKILRIAILSRAPHMIRDRKYHLKTYRQCCVGTE 240 VPSEKILRAGKILRIAILSRAPHMIRDRKYHLKTYRQCCVGTE Sbjct: 186 -----------------VPSEKILRAGKILRIAILSRAPHMIRDRKYHLKTYRQCCVGTE 228 Query: 241 LVDWMIQQTSCVHSRTQAVGMWQVLLEDGVLNHVDQERHFQDKYLFYRFLDDEREDAPLP 300 LVDWMIQQTSCVHSRTQAVGMWQVLLEDGVLNHVDQERHFQDKYLFYRFLDDEREDAPLP Sbjct: 229 LVDWMIQQTSCVHSRTQAVGMWQVLLEDGVLNHVDQERHFQDKYLFYRFLDDEREDAPLP 288 Query: 301 TEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYDELLHIKALSHL 360 TEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYDELLHIKALSHL Sbjct: 289 TEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYDELLHIKALSHL 348 Query: 361 STTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDD 420 STTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDD Sbjct: 349 STTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDD 408 Query: 421 FGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKV 480 FGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKV Sbjct: 409 FGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKV 468 Query: 481 P 481 P Sbjct: 469 P 469 >1XDV-A nrPDB Length = 847 Score = 328 bits (842), Expect = 5e-90, Method: Composition-based stats. Identities = 67/276 (24%), Positives = 123/276 (44%), Gaps = 20/276 (7%) Query: 748 FDSLTPLPEQEGPTTGTVGTFELMS--SKDLAYQMTTYDWELFNCVHELELIYHTFGRHN 805 F S P E G + TF+L++ ++A Q+T + +L+ V EL+ + + + Sbjct: 557 FQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKED 616 Query: 806 FKKTTANLDLFLRRFNEIQFWVVTEVCLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFA 865 + + NL +R + W + L +RV ++ + I+I +E N N Sbjct: 617 KEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLE 676 Query: 866 IVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTAAKLEPPLIPFMP 925 +V +++ V RL T+E++PS+ KK E L +++ Y + PP +PF Sbjct: 677 VVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHEL--SEDHYKKYLAKLRSINPPCVPFFG 734 Query: 926 LLIKDMTFTHEGNKTFI----DNLVNFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQ 981 + + ++ T EGN + L+NF K R +A ++ Y++QP+ + Sbjct: 735 IYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPY------CLRVES 788 Query: 982 DVRSYVRQLNVIDNQRT------LSQMSHRLEPRRP 1011 D++ + LN + N L S +EPR P Sbjct: 789 DIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNP 824 >5OVF-A nrPDB Length = 490 Score = 328 bits (840), Expect = 9e-90, Method: Composition-based stats. Identities = 67/276 (24%), Positives = 123/276 (44%), Gaps = 20/276 (7%) Query: 748 FDSLTPLPEQEGPTTGTVGTFELMS--SKDLAYQMTTYDWELFNCVHELELIYHTFGRHN 805 F S P E G + TF+L++ ++A Q+T + +L+ V EL+ + + + Sbjct: 195 FQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKED 254 Query: 806 FKKTTANLDLFLRRFNEIQFWVVTEVCLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFA 865 + + NL +R + W + L +RV ++ + I+I +E N N Sbjct: 255 KEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLE 314 Query: 866 IVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTAAKLEPPLIPFMP 925 +V +++ V RL T+E++PS+ KK E L +++ Y + PP +PF Sbjct: 315 VVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHEL--SEDHYKKYLAKLRSINPPCVPFFG 372 Query: 926 LLIKDMTFTHEGNKTFI----DNLVNFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQ 981 + + ++ T EGN + L+NF K R +A ++ Y++QP+ + Sbjct: 373 IYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPY------CLRVES 426 Query: 982 DVRSYVRQLNVIDNQRT------LSQMSHRLEPRRP 1011 D++ + LN + N L S +EPR P Sbjct: 427 DIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNP 462 >6EIE-A nrPDB Length = 490 Score = 325 bits (833), Expect = 6e-89, Method: Composition-based stats. Identities = 68/276 (24%), Positives = 124/276 (44%), Gaps = 20/276 (7%) Query: 748 FDSLTPLPEQEGPTTGTVGTFELMS--SKDLAYQMTTYDWELFNCVHELELIYHTFGRHN 805 F+S P E G + TF+LM+ ++A Q+T + +L+ V EL+ + + + Sbjct: 195 FESPPPPIEWHISKPGHIETFDLMTLHPIEIARQLTLLESDLYRKVQPSELVGSVWTKED 254 Query: 806 FKKTTANLDLFLRRFNEIQFWVVTEVCLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFA 865 + + NL +R + W + +RV +L + I+I ++ N N Sbjct: 255 KEINSPNLLKMIRHTTNLTLWFEKCIVEAENFEERVAVLSRIIEILQVFQDLNNFNGVLE 314 Query: 866 IVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTAAKLEPPLIPFMP 925 IV +++V+V RL T+E L + +K E L + + Y + + PP +PF Sbjct: 315 IVSAVNSVSVYRLDHTFEALQERKRKILDEAVEL--SQDHFKKYLVKLKSINPPCVPFFG 372 Query: 926 LLIKDMTFTHEGNKTFI----DNLVNFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQ 981 + + ++ T EGN F+ +L+NF K R +A ++ Y++QP+ + Sbjct: 373 IYLTNILKTEEGNNDFLTRHGKDLINFSKRRKVAEITGEIQQYQNQPY------CLRIEP 426 Query: 982 DVRSYVRQLNVIDNQRT------LSQMSHRLEPRRP 1011 D+R + LN + + L S +EPR P Sbjct: 427 DMRRFFENLNPMGSASEKEFTDYLFNKSLEIEPRNP 462 >2IJE-S nrPDB Length = 240 Score = 296 bits (759), Expect = 2e-80, Method: Composition-based stats. Identities = 56/243 (23%), Positives = 113/243 (46%), Gaps = 7/243 (2%) Query: 770 LMSSKDLAYQMTTYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVT 829 L S+ ++A Q+T D +F + E + + + T + + FN + ++ + Sbjct: 3 LGSALEIAEQLTLLDHLVFKSIPYEEFFGQGWMKAEKYERTPYIMKTTKHFNHVSNFIAS 62 Query: 830 EVCLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKF 889 E+ +S R ++K++ +A C+ N N+ I ++ A+ RL TW K+ + Sbjct: 63 EIIRNEDISARASAIEKWVAVADICRCLHNYNAVLEITSSINRSAIFRLKKTWLKVSKQT 122 Query: 890 KKFYAEFESLMDPSRNHRAYRLTAAKLEPPLIPFMPLLIKDMTFTHEGNKTFI-DNLVNF 948 K + + L+ + R + +PP +P++ + + D+ F EG + D LVNF Sbjct: 123 KSLLDKLQKLVSSDGRFKNLRESLRNCDPPCVPYLGMYLTDLVFIEEGTPNYTEDGLVNF 182 Query: 949 EKMRMIANTARTVRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEP 1008 KMRMI++ R +R ++ + D V Y+ + + ++ +L + S +EP Sbjct: 183 SKMRMISHIIREIRQFQQTTYKIDP------QPKVIQYLLDESFMLDEESLYESSLLIEP 236 Query: 1009 RRP 1011 + P Sbjct: 237 KLP 239 >4L9M-A nrPDB Length = 559 Score = 261 bits (667), Expect = 1e-69, Method: Composition-based stats. Identities = 55/245 (22%), Positives = 109/245 (44%), Gaps = 10/245 (4%) Query: 768 FELMSSKDLAYQMTTYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWV 827 F+ + ++L+ +T +++ F + + Y + ++ K ++ + N I WV Sbjct: 153 FDHLEPEELSEHLTYLEFKSFRRISFSD--YQNYLVNSCVKENPTMERSIALCNGISQWV 210 Query: 828 VTEVCLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPS 887 V R ++ KFI++A + +N N+ A++ GL + ++SRL T +P Sbjct: 211 QLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPH 270 Query: 888 KFKKFYAEFESLMDPSRNHRAYRLTAAKLEPPLIPFMPLLIKDMTFTHEGNKTFI-DNLV 946 + K E L+ SRN+ YR + IP + + +KD+ +E ++ D V Sbjct: 271 EINKVLGEMTELLSSSRNYDNYRRAYGECTDFKIPILGVHLKDLISLYEAMPDYLEDGKV 330 Query: 947 NFEKMRMIAN-TARTVRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHR 1005 N K+ + N + V+ P +ANK+ V L++ + + ++S+ Sbjct: 331 NVHKLLALYNHISELVQLQEVAP----PLEANKDL--VHLLTLSLDLYYTEDEIYELSYA 384 Query: 1006 LEPRR 1010 EPR Sbjct: 385 REPRN 389 >6AXF-A nrPDB Length = 397 Score = 243 bits (620), Expect = 3e-64, Method: Composition-based stats. Identities = 54/245 (22%), Positives = 101/245 (41%), Gaps = 10/245 (4%) Query: 768 FELMSSKDLAYQMTTYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWV 827 F+ + +LA +T ++ F + L YH+F H L+ F+ FN + WV Sbjct: 153 FDHLEPMELAEHLTYLEYRSFCKI--LFQDYHSFVTHGCTVDNPVLERFISLFNSVSQWV 210 Query: 828 VTEVCLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPS 887 + +R ++ F+ +A + +N N+ A+V GLS+ ++SRL T + Sbjct: 211 QLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLMAVVGGLSHSSISRLKETHSHVSP 270 Query: 888 KFKKFYAEFESLMDPSRNHRAYRLTAAKLEPPLIPFMPLLIKDMTFTHEGNKTFID---N 944 + K + L+ + N+ YR A P + + +KD+ ++D Sbjct: 271 ETIKLWEGLTELVTATGNYGNYRRRLAACVGFRFPILGVHLKDLVALQLALPDWLDPART 330 Query: 945 LVNFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSH 1004 +N KM+ + + + S QAN + + L+ + L Q+S Sbjct: 331 RLNGAKMKQLFSILEELAMVTS---LRPPVQANPDL--LSLLTVSLDQYQTEDELYQLSL 385 Query: 1005 RLEPR 1009 + EPR Sbjct: 386 QREPR 390 >6AXG-A nrPDB Length = 418 Score = 231 bits (589), Expect = 1e-60, Method: Composition-based stats. Identities = 51/245 (20%), Positives = 98/245 (40%), Gaps = 8/245 (3%) Query: 768 FELMSSKDLAYQMTTYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWV 827 F+ + + +LA +T ++ F + +L ++ + L+ + N + WV Sbjct: 155 FDHLETGELAQHLTYLEFRSFQAITPQDL--RSYVLQGSVRGCPALEGSVGLSNSVSRWV 212 Query: 828 VTEVCLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPS 887 V +R Q+L KFI +A + +N N+ A+ GL + A+SRL + L Sbjct: 213 QVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSP 272 Query: 888 KFKKFYAEFESLMDPSRNHRAYRLTAAKLEPPLIPFMPLLIKDMTFTHEGNKTFI-DNLV 946 K E L+ N+ YR T A +P + + +KD+ HE + D + Sbjct: 273 DSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRL 332 Query: 947 NFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRL 1006 + K+ + +R + N + L++ + + ++S+ Sbjct: 333 HLPKLNNLY-----LRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAR 387 Query: 1007 EPRRP 1011 EPR P Sbjct: 388 EPRCP 392 Score = 29.7 bits (65), Expect = 6.0, Method: Composition-based stats. Identities = 23/110 (20%), Positives = 49/110 (44%), Gaps = 9/110 (8%) Query: 504 TPEKILEHFLETIRLEPSLNEATDSVLNDFVMMHCVFMPNTQLCPALVAHYHAQPSQGTE 563 + +++LE +++ SL D +LN + MH +P+ L L+ Y Q + G Sbjct: 15 SEDELLEKCIQSFDSAGSLCHE-DHMLNMVLAMHSWVLPSADLAARLLTSY--QKATGDT 71 Query: 564 QERMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVAMAFLEEFYVSVSDDA 613 QE + ++ LV W + +++ +D + F+ +V+ + Sbjct: 72 QEL------RRLQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREG 115 >3QXL-A nrPDB Length = 271 Score = 219 bits (557), Expect = 6e-57, Method: Composition-based stats. Identities = 58/249 (23%), Positives = 109/249 (43%), Gaps = 12/249 (4%) Query: 768 FELM--SSKDLAYQMTTYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQF 825 F+++ + ++ A Q+T D +F + EL + + N+ F RRFN++ F Sbjct: 26 FDVLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPNVVAFTRRFNQVSF 85 Query: 826 WVVTEVCLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKL 885 WVV E+ L R ++L F+KIA E NL+S ++V L + + RL TW L Sbjct: 86 WVVREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFRLTKTWALL 145 Query: 886 PSKFKKFYAEFESLMDPSRNHRAYRLTAAKLE-PPLIPFMPLLIKDMTFTHEGNKTFIDN 944 K K + + + LM N++ R L+ P IP++ + + D+ + Sbjct: 146 NRKDKTTFEKLDYLMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYIDSAYPASGSI 205 Query: 945 LVNFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDN-----QRTL 999 + N ++ + N R + + + V+ Y++ + I+ + Sbjct: 206 MENEQRSNQMNNILRIIADLQVS----CSYDHLTTLPHVQKYLKSVRYIEELQKFVEDDN 261 Query: 1000 SQMSHRLEP 1008 ++S R+EP Sbjct: 262 YKLSLRIEP 270 >5CM8-A nrPDB Length = 473 Score = 199 bits (506), Expect = 6e-51, Method: Composition-based stats. Identities = 66/359 (18%), Positives = 137/359 (38%), Gaps = 51/359 (14%) Query: 688 VAASVKEVISAVADKLGSGEGLIIVKMNSGGEKVVLKSNDVSVFTTLTINGRLFACPREQ 747 +A+ ++ S V +L E ++ + E VV S D+ N R PR Sbjct: 126 LASHPEDFGSEVKGQLDRLESFLLRTGYAAREGVVGGSADLI------RNLRARVDPR-- 177 Query: 748 FDSLTPLPEQEGPTTGTVGTFELMSSKDLAYQMTTYDWELFNCVHELELIYHTFG---RH 804 L G + + + LA Q+T D ELF + + + +G R Sbjct: 178 APDLPKPLALPGDSPADPTDVLVFLADHLAEQLTLLDAELFLNLIPSQCLGGLWGHRDRP 237 Query: 805 NFKKTTANLDLFLRRFNEIQFWVVTEVCLCSQ--------------LSKRVQLLKKFIKI 850 ++ + +FN++ VV+ V + +R +LL+K+I++ Sbjct: 238 GHSHLCPSVRATVTQFNKVAGAVVSSVLGATSIGEGPREVTVRPLRPPQRARLLEKWIRV 297 Query: 851 AAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYR 910 A C+ +N +S +A+V L + + RL W + + ++ + N+ R Sbjct: 298 AEECRLLRNFSSVYAVVSALQSSPIHRLRAAWGETTRDSLRVFSSLCQIFSEEDNYSQSR 357 Query: 911 LTA---AKLEPP-----------------LIPFMPLLIKDMTFTHEGNKTFIDN-LVNFE 949 K +PP ++P++ +KD+ +K ++N +NF+ Sbjct: 358 ELLTQEVKPQPPVEPHSKKAPRSGFRGGGVVPYLGTFLKDLVMLDAASKDELENGYINFD 417 Query: 950 KMRMIANTARTVRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEP 1008 K R + + + D + + D++ +++ L + + ++S +EP Sbjct: 418 KRRKEFAILSELLRLQKECRGYD----LRPNSDIQQWLQGLQPL-TEAQSHRVSCEVEP 471 >1CX4-A nrPDB Length = 305 Score = 151 bits (381), Expect = 2e-36, Method: Composition-based stats. Identities = 40/151 (26%), Positives = 73/151 (48%), Gaps = 12/151 (7%) Query: 325 DAHMRMILRKPPGQRTVDDLEIIYDELLHIKALSHLSTTVKRELAGVLIFESHAKGGTVL 384 DA R+I K QR + L+ ++L +L ++ + FE K G + Sbjct: 15 DAESRIIHPKTDDQR--NRLQEACKDILL---FKNLDPEQMSQVLDAM-FEKLVKEGEHV 68 Query: 385 FNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGD---DFGKLALVNDAPRAASIVLRED 441 +QG++G ++Y+I +G+ ++ + GV + D FG+LAL+ + PRAA+I Sbjct: 69 IDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITATSP 128 Query: 442 NCHFLRVDKEDFNRILRDVEANTVRLKEHDQ 472 +D+ F RI+ V+ N + K ++ Sbjct: 129 GA-LWGLDRVTFRRII--VKNNAKKRKMYES 156 Score = 100 bits (248), Expect = 4e-21, Method: Composition-based stats. Identities = 37/159 (23%), Positives = 64/159 (40%), Gaps = 19/159 (11%) Query: 329 RMILRKPPGQRTVDDLEIIYDELL-HIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQ 387 R+I++ +R +Y+ + + L L + + ++ V I G + Q Sbjct: 141 RIIVKNNAKKRK------MYESFIESLPFLKSLEVSERLKVVDV-IGTKVYNDGEQIIAQ 193 Query: 388 GEEGTSWYIILKGSVNVVIYGKGV----------VCTLHEGDDFGKLALVNDAPRAASIV 437 G+ S++I+ G V + + KG + G FG+LALV + PRAAS Sbjct: 194 GDSADSFFIVESGEVRITMKRKGKSDIEENGAVEIARCLRGQYFGELALVTNKPRAASAH 253 Query: 438 LREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLV 476 L +D + F R+L R ++ LV Sbjct: 254 A-IGTVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQLV 291 Score = 93.2 bits (230), Expect = 5e-19, Method: Composition-based stats. Identities = 29/143 (20%), Positives = 64/143 (44%), Gaps = 9/143 (6%) Query: 26 RSSEDVDIIFTRLKGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLA 85 ++ + + + K + F+ P + Q+ + + +++G + QGD G N+Y + Sbjct: 24 KTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDR 83 Query: 86 GSLDVKVSETSSHQDAVTICTLGIGTAFGE-SILDNTPRHATIVTRESSELLRIEQEDFK 144 G+ D+ V + +FGE +++ NTPR ATI L +++ F+ Sbjct: 84 GTFDIYVKCDGVG---RCVGNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFR 140 Query: 145 ALW-----EKYRQYMAGLLAPPY 162 + +K + Y + + + P+ Sbjct: 141 RIIVKNNAKKRKMYESFIESLPF 163 Score = 69.0 bits (167), Expect = 9e-12, Method: Composition-based stats. Identities = 21/123 (17%), Positives = 48/123 (39%), Gaps = 5/123 (4%) Query: 38 LKGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSS 97 ++ + + + ++ + G + QGD +++ V +G + + + Sbjct: 158 IESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQGDSADSFFIVESGEVRITMKRKGK 217 Query: 98 HQ----DAVTICTLGIGTAFGE-SILDNTPRHATIVTRESSELLRIEQEDFKALWEKYRQ 152 AV I G FGE +++ N PR A+ + + L ++ + F+ L + Sbjct: 218 SDIEENGAVEIARCLRGQYFGELALVTNKPRAASAHAIGTVKCLAMDVQAFERLLGPCME 277 Query: 153 YMA 155 M Sbjct: 278 IMK 280 >4X6Q-B nrPDB Length = 416 Score = 148 bits (374), Expect = 1e-35, Method: Composition-based stats. Identities = 39/151 (25%), Positives = 73/151 (48%), Gaps = 12/151 (7%) Query: 325 DAHMRMILRKPPGQRTVDDLEIIYDELLHIKALSHLSTTVKRELAGVLIFESHAKGGTVL 384 DA R+I K QR + L+ ++L +L ++ + FE K G + Sbjct: 126 DAESRIIHPKTDDQR--NRLQEACKDILL---FKNLDPEQMSQVLDAM-FEKLVKEGEHV 179 Query: 385 FNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGD---DFGKLALVNDAPRAASIVLRED 441 +QG++G ++Y+I +G+ ++ + GV + D FG+LAL+ + P+AA+I Sbjct: 180 IDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPKAATITATSP 239 Query: 442 NCHFLRVDKEDFNRILRDVEANTVRLKEHDQ 472 +D+ F RI+ V+ N + K ++ Sbjct: 240 GA-LWGLDRVTFRRII--VKNNAKKRKMYES 267 Score = 101 bits (251), Expect = 2e-21, Method: Composition-based stats. Identities = 37/159 (23%), Positives = 64/159 (40%), Gaps = 19/159 (11%) Query: 329 RMILRKPPGQRTVDDLEIIYDELL-HIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQ 387 R+I++ +R +Y+ + + L L + + ++ V I G + Q Sbjct: 252 RIIVKNNAKKRK------MYESFIESLPFLKSLEVSERLKVVDV-IGTKVYNDGEQIIAQ 304 Query: 388 GEEGTSWYIILKGSVNVVIYGKGV----------VCTLHEGDDFGKLALVNDAPRAASIV 437 G+ S++I+ G V + + KG + G FG+LALV + PRAAS Sbjct: 305 GDLADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCFRGQYFGELALVTNKPRAASAH 364 Query: 438 LREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLV 476 L +D + F R+L R ++ LV Sbjct: 365 A-IGTVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQLV 402 Score = 90.9 bits (224), Expect = 3e-18, Method: Composition-based stats. Identities = 28/143 (19%), Positives = 64/143 (44%), Gaps = 9/143 (6%) Query: 26 RSSEDVDIIFTRLKGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLA 85 ++ + + + K + F+ P + Q+ + + +++G + QGD G N+Y + Sbjct: 135 KTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDR 194 Query: 86 GSLDVKVSETSSHQDAVTICTLGIGTAFGE-SILDNTPRHATIVTRESSELLRIEQEDFK 144 G+ D+ V + +FGE +++ NTP+ ATI L +++ F+ Sbjct: 195 GTFDIYVKCDGVG---RCVGNYDNRGSFGELALMYNTPKAATITATSPGALWGLDRVTFR 251 Query: 145 ALW-----EKYRQYMAGLLAPPY 162 + +K + Y + + + P+ Sbjct: 252 RIIVKNNAKKRKMYESFIESLPF 274 Score = 70.5 bits (171), Expect = 4e-12, Method: Composition-based stats. Identities = 21/123 (17%), Positives = 50/123 (40%), Gaps = 5/123 (4%) Query: 38 LKGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSS 97 ++ + + + ++ + G + QGD+ +++ V +G + + + Sbjct: 269 IESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQGDLADSFFIVESGEVKITMKRKGK 328 Query: 98 HQ----DAVTICTLGIGTAFGE-SILDNTPRHATIVTRESSELLRIEQEDFKALWEKYRQ 152 + AV I G FGE +++ N PR A+ + + L ++ + F+ L + Sbjct: 329 SEVEENGAVEIARCFRGQYFGELALVTNKPRAASAHAIGTVKCLAMDVQAFERLLGPCME 388 Query: 153 YMA 155 M Sbjct: 389 IMK 391 >5KBF-A nrPDB Length = 301 Score = 146 bits (369), Expect = 3e-35, Method: Composition-based stats. Identities = 39/130 (30%), Positives = 74/130 (56%), Gaps = 4/130 (3%) Query: 347 IYDELL-HIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVV 405 +Y+++L H+ L + + ++A L +S G ++ +GEEG +++I++ G+ V Sbjct: 162 MYEDILSHVNILKDMDPYERCKVADCLKSKS-YNDGEIIIKEGEEGDTFFILIDGNA-VA 219 Query: 406 IYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTV 465 V+ T +GD FG+LAL+ + PRAA+I ++ C + +D++ F R+L +E Sbjct: 220 SKDNKVIKTYTKGDYFGELALLKNKPRAATIKA-QNFCQVVYLDRKSFKRLLGPIEDILH 278 Query: 466 RLKEHDQDVL 475 R E+ + VL Sbjct: 279 RNVENYKKVL 288 Score = 92.8 bits (229), Expect = 7e-19, Method: Composition-based stats. Identities = 37/159 (23%), Positives = 69/159 (43%), Gaps = 15/159 (9%) Query: 334 KPPGQRTVDDLEIIYDELLHIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTS 393 K + E + + L +HL+ + F+ + + G + N+G+ G Sbjct: 31 KKDEKEKAKIREALNESFL----FNHLNKKEFEIIVNA-FFDKNVEKGVNIINEGDYGDL 85 Query: 394 WYIILKGSVNVVI----YGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVD 449 Y+I +G V + K V+ L D FG+LAL+ ++ RAA+ CH +D Sbjct: 86 LYVIDQGEVEIYKTKENNKKEVLTVLKSKDVFGELALLYNSKRAATA-TALTKCHLWALD 144 Query: 450 KEDFNRILRDVEANTVRLKEHD---QDVLVLEKVPAGNR 485 +E F I++D+ + K ++ V +L+ + R Sbjct: 145 RESFTYIIKDM--VAKKRKMYEDILSHVNILKDMDPYER 181 Score = 86.7 bits (213), Expect = 5e-17, Method: Composition-based stats. Identities = 25/114 (21%), Positives = 50/114 (43%), Gaps = 3/114 (2%) Query: 34 IFTRLKGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVS 93 I L F + I + +N+EKG+ + +GD G Y + G +++ + Sbjct: 40 IREALNESFLFNHLNKKEFEIIVNAFFDKNVEKGVNIINEGDYGDLLYVIDQGEVEIYKT 99 Query: 94 ETSSHQDAVTICTLGIGTAFGE-SILDNTPRHATIVTRESSELLRIEQEDFKAL 146 + ++ ++ + L FGE ++L N+ R AT L +++E F + Sbjct: 100 KENNKKE--VLTVLKSKDVFGELALLYNSKRAATATALTKCHLWALDRESFTYI 151 Score = 81.7 bits (200), Expect = 1e-15, Method: Composition-based stats. Identities = 25/116 (21%), Positives = 51/116 (43%), Gaps = 8/116 (6%) Query: 33 IIFTRLKGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKV 92 + L V + P ++ C ++ G + ++G+ G ++ ++ G Sbjct: 162 MYEDILSHVNILKDMDPYERCKVADCLKSKSYNDGEIIIKEGEEGDTFFILIDG------ 215 Query: 93 SETSSHQDAVTICTLGIGTAFGE-SILDNTPRHATIVTRESSELLRIEQEDFKALW 147 + +D I T G FGE ++L N PR ATI + +++ ++++ FK L Sbjct: 216 -NAVASKDNKVIKTYTKGDYFGELALLKNKPRAATIKAQNFCQVVYLDRKSFKRLL 270 >2DHZ-A nrPDB Length = 120 Score = 139 bits (350), Expect = 6e-33, Method: Composition-based stats. Identities = 43/106 (40%), Positives = 67/106 (63%), Gaps = 7/106 (6%) Query: 668 DEVLFKVYCIDHTYTTIRVPVAASVKEVISAVADKL-------GSGEGLIIVKMNSGGEK 720 DE+ +VY DH+Y TIR ++ASV++++ +V +KL G + LI+V ++S GEK Sbjct: 8 DEIFCRVYMPDHSYVTIRSRLSASVQDILGSVTEKLQYSEEPAGREDSLILVAVSSSGEK 67 Query: 721 VVLKSNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTTGTVG 766 V+L+ + VFT L IN LFAC R+ +++L PLPE+ + G Sbjct: 68 VLLQPTEDCVFTALGINSHLFACTRDSYEALVPLPEEIQVSPGDTE 113 >5DYK-A nrPDB Length = 853 Score = 138 bits (348), Expect = 1e-32, Method: Composition-based stats. Identities = 33/128 (25%), Positives = 65/128 (50%), Gaps = 8/128 (6%) Query: 25 ERSSEDVDIIFTRLKGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVL 84 E+ SED+D+I T LK + N + + + + G + +QG+ G+ ++ + Sbjct: 40 EKLSEDIDMIKTSLKNNLVCSTLNDNEILTLSNYMQFFVFKSGNLVIKQGEKGSYFFIIN 99 Query: 85 AGSLDVKVSETSSHQDAVTICTLGIGTAFGE-SILDNTPRHATIVTRESSELLRIEQEDF 143 +G DV V++ + T+G G++FGE +++ NT R ATI+ L +++ F Sbjct: 100 SGKFDVYVNDK-------KVKTMGKGSSFGEAALIHNTQRSATIIAETDGTLWGVQRSTF 152 Query: 144 KALWEKYR 151 +A ++ Sbjct: 153 RATLKQLS 160 Score = 113 bits (283), Expect = 3e-25, Method: Composition-based stats. Identities = 34/126 (26%), Positives = 59/126 (46%), Gaps = 4/126 (3%) Query: 351 LLHIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKG 410 + + +L+ L + + G + +GE G+ +YII G V + + K Sbjct: 413 IKKMYIFRYLTDKQCNLLIEAFRT-TRYEEGDYIIQEGEVGSRFYIIKNGEVEI-VKNKK 470 Query: 411 VVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRD--VEANTVRLK 468 + TL + D FG+ AL+ D PR AS++ + +N VDK F +I++ + R+K Sbjct: 471 RLRTLGKNDYFGERALLYDEPRTASVISKVNNVECWFVDKSVFLQIIQGPMLAHLEERIK 530 Query: 469 EHDQDV 474 D V Sbjct: 531 MQDTKV 536 Score = 88.2 bits (217), Expect = 2e-17, Method: Composition-based stats. Identities = 32/123 (26%), Positives = 62/123 (50%), Gaps = 3/123 (2%) Query: 338 QRTVDDLEIIYDELLHIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYII 397 ++ +D+++I L + S L+ L+ + F K G ++ QGE+G+ ++II Sbjct: 40 EKLSEDIDMIKTSLKNNLVCSTLNDNEILTLSNYMQF-FVFKSGNLVIKQGEKGSYFFII 98 Query: 398 LKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRIL 457 G +V + K V T+ +G FG+ AL+++ R+A+I+ D V + F L Sbjct: 99 NSGKFDVYVNDK-KVKTMGKGSSFGEAALIHNTQRSATIIAETDG-TLWGVQRSTFRATL 156 Query: 458 RDV 460 + + Sbjct: 157 KQL 159 Score = 84.4 bits (207), Expect = 3e-16, Method: Composition-based stats. Identities = 30/143 (20%), Positives = 60/143 (41%), Gaps = 3/143 (2%) Query: 329 RMILRKPPGQRTVDDLEIIYDELLHIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQG 388 R R Q + + + + L+ K + + ++ K G + QG Sbjct: 149 RSTFRATLKQLSNRNFNENRTFIDSVSVFDMLTEAQKNMITNACVIQNF-KSGETIVKQG 207 Query: 389 EEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRV 448 + G YI+ +G V I + + L +G FG+ AL+ D PR+A+I+ +E + Sbjct: 208 DYGDVLYILKEGKATVYINDE-EIRVLEKGSYFGERALLYDEPRSATIIAKEPTA-CASI 265 Query: 449 DKEDFNRILRDVEANTVRLKEHD 471 ++ N +L +++ R + Sbjct: 266 CRKLLNIVLGNLQVVLFRNIMTE 288 Score = 83.2 bits (204), Expect = 6e-16, Method: Composition-based stats. Identities = 20/113 (17%), Positives = 52/113 (46%), Gaps = 9/113 (7%) Query: 38 LKGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSS 97 +K + F + E+G + ++G++G+ +Y + G +++ ++ Sbjct: 413 IKKMYIFRYLTDKQCNLLIEAFRTTRYEEGDYIIQEGEVGSRFYIIKNGEVEIVKNKK-- 470 Query: 98 HQDAVTICTLGIGTAFGE-SILDNTPRHATIVTRE-SSELLRIEQEDFKALWE 148 + TLG FGE ++L + PR A+++++ + E +++ F + + Sbjct: 471 -----RLRTLGKNDYFGERALLYDEPRTASVISKVNNVECWFVDKSVFLQIIQ 518 Score = 79.7 bits (195), Expect = 6e-15, Method: Composition-based stats. Identities = 28/117 (23%), Positives = 49/117 (41%), Gaps = 8/117 (6%) Query: 36 TRLKGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSET 95 T + V F+ I +N + G T+ +QGD G Y + G V +++ Sbjct: 169 TFIDSVSVFDMLTEAQKNMITNACVIQNFKSGETIVKQGDYGDVLYILKEGKATVYINDE 228 Query: 96 SSHQDAVTICTLGIGTAFGE-SILDNTPRHATIVTRESSELLRIEQEDFKALWEKYR 151 I L G+ FGE ++L + PR ATI+ +E + I ++ + + Sbjct: 229 E-------IRVLEKGSYFGERALLYDEPRSATIIAKEPTACASICRKLLNIVLGNLQ 278 Score = 32.0 bits (71), Expect = 1.4, Method: Composition-based stats. Identities = 19/96 (19%), Positives = 35/96 (36%), Gaps = 2/96 (2%) Query: 346 IIYDELLHIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVV 405 I+ + L + S +LA I + +L + + I+L+G V + Sbjct: 285 IMTEALQQSEIFKQFSGDQLNDLADTAIVRDYPANYNILHKDKVKSVKYIIVLEGKVELF 344 Query: 406 IYGKGVVCTLHEGDDFGKLALVN-DAPRAASIVLRE 440 + + L G FG ++N P +I E Sbjct: 345 L-DDTSIGILSRGMSFGDQYVLNQKQPFKHTIKSLE 379 >1WGY-A nrPDB Length = 104 Score = 136 bits (343), Expect = 4e-32, Method: Composition-based stats. Identities = 29/97 (29%), Positives = 58/97 (59%), Gaps = 1/97 (1%) Query: 668 DEVLFKVYCIDHTYTTIRVPVAASVKEVISAVADKLG-SGEGLIIVKMNSGGEKVVLKSN 726 +E+ VY +H+Y +++ V++ +E++ VA+K+ + E L +V + GEK L+ N Sbjct: 8 EEIFCHVYITEHSYVSVKAKVSSIAQEILKVVAEKIQYAEEDLALVAITFSGEKHELQPN 67 Query: 727 DVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTTG 763 D+ + +L +GR++ ++ D+L P E GP++G Sbjct: 68 DLVISKSLEASGRIYVYRKDLADTLNPFAENSGPSSG 104 >3SHR-A nrPDB Length = 299 Score = 134 bits (338), Expect = 1e-31, Method: Composition-based stats. Identities = 37/146 (25%), Positives = 69/146 (47%), Gaps = 13/146 (8%) Query: 22 RPLERSSEDVDIIFTRLKGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWY 81 R +S D+I + + + +++I C Y K + ++GD+G+ Y Sbjct: 25 RKFTKSERSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVY 84 Query: 82 AVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGE-SILDNTPRHATIVTRESSELLRIEQ 140 + G ++V ++ V +CT+G G FGE +IL N R AT+ T + +L I++ Sbjct: 85 VMEDGKVEVT-------KEGVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDR 137 Query: 141 EDFKALWE-----KYRQYMAGLLAPP 161 + F+ + K+ +YM L + P Sbjct: 138 QCFQTIMMRTGLIKHTEYMEFLKSVP 163 Score = 134 bits (336), Expect = 3e-31, Method: Composition-based stats. Identities = 33/110 (30%), Positives = 53/110 (48%), Gaps = 2/110 (1%) Query: 38 LKGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSS 97 LK V F+ +L ++ + E G + RQG G ++ + G ++V E S Sbjct: 159 LKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGKVNVT-REDSP 217 Query: 98 HQDAVTICTLGIGTAFGESILDNTP-RHATIVTRESSELLRIEQEDFKAL 146 ++D V + TLG G FGE L R A ++ E+ L I+++ FK L Sbjct: 218 NEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVTCLVIDRDSFKHL 267 Score = 124 bits (312), Expect = 2e-28, Method: Composition-based stats. Identities = 34/124 (27%), Positives = 59/124 (47%), Gaps = 7/124 (5%) Query: 351 LLHIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKG 410 L + L + +LA VL E+H + G + QG G +++II KG VNV Sbjct: 159 LKSVPTFQSLPEEILSKLADVLE-ETHYENGEYIIRQGARGDTFFIISKGKVNVTREDSP 217 Query: 411 -----VVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTV 465 + TL +GD FG+ AL + R A+++ E L +D++ F ++ ++ + Sbjct: 218 NEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEA-VTCLVIDRDSFKHLIGGLDDVSN 276 Query: 466 RLKE 469 + E Sbjct: 277 KAYE 280 Score = 80.9 bits (198), Expect = 2e-15, Method: Composition-based stats. Identities = 27/130 (20%), Positives = 59/130 (45%), Gaps = 6/130 (4%) Query: 328 MRMILRKPPGQRTVDDLEIIYDELLHIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQ 387 M+ + +R+ D ++ +L + +L + +E+ + + K + + Sbjct: 21 MQAFRKFTKSERSKDLIKEA---ILDNDFMKNLELSQIQEIVDCMYPVEYGKDS-CIIKE 76 Query: 388 GEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLR 447 G+ G+ Y++ G V V G +CT+ G FG+LA++ + R A++ N Sbjct: 77 GDVGSLVYVMEDGKVEVTKEG-VKLCTMGPGKVFGELAILYNCTRTATVKTLV-NVKLWA 134 Query: 448 VDKEDFNRIL 457 +D++ F I+ Sbjct: 135 IDRQCFQTIM 144 >4Z07-A nrPDB Length = 262 Score = 134 bits (338), Expect = 1e-31, Method: Composition-based stats. Identities = 36/142 (25%), Positives = 69/142 (48%), Gaps = 13/142 (9%) Query: 26 RSSEDVDIIFTRLKGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLA 85 +S + D+I + + + +++I C Y K + ++GD+G+ Y + Sbjct: 12 KSPQSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMED 71 Query: 86 GSLDVKVSETSSHQDAVTICTLGIGTAFGE-SILDNTPRHATIVTRESSELLRIEQEDFK 144 G ++V ++ V +CT+G G FGE +IL N R AT+ T + +L I+++ F+ Sbjct: 72 GKVEVT-------KEGVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQ 124 Query: 145 ALWE-----KYRQYMAGLLAPP 161 + K+ +YM L + P Sbjct: 125 TIMMRTGLIKHTEYMEFLKSVP 146 Score = 133 bits (334), Expect = 4e-31, Method: Composition-based stats. Identities = 33/110 (30%), Positives = 53/110 (48%), Gaps = 2/110 (1%) Query: 38 LKGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSS 97 LK V F+ +L ++ + E G + RQG G ++ + G+++V E S Sbjct: 142 LKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTVNVT-REDSP 200 Query: 98 HQDAVTICTLGIGTAFGESILDNTP-RHATIVTRESSELLRIEQEDFKAL 146 +D V + TLG G FGE L R A ++ E+ L I+++ FK L Sbjct: 201 SEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVTCLVIDRDSFKHL 250 Score = 125 bits (313), Expect = 1e-28, Method: Composition-based stats. Identities = 33/121 (27%), Positives = 59/121 (48%), Gaps = 7/121 (5%) Query: 351 LLHIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKG 410 L + L + +LA VL E+H + G + QG G +++II KG+VNV Sbjct: 142 LKSVPTFQSLPEEILSKLADVLE-ETHYENGEYIIRQGARGDTFFIISKGTVNVTREDSP 200 Query: 411 -----VVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTV 465 + TL +GD FG+ AL + R A+++ E L +D++ F ++ ++ + Sbjct: 201 SEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEA-VTCLVIDRDSFKHLIGGLDDVSN 259 Query: 466 R 466 + Sbjct: 260 K 260 Score = 82.8 bits (203), Expect = 7e-16, Method: Composition-based stats. Identities = 26/126 (20%), Positives = 56/126 (44%), Gaps = 8/126 (6%) Query: 332 LRKPPGQRTVDDLEIIYDELLHIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEG 391 K P + + I+ ++ + +L + +E+ + + K + +G+ G Sbjct: 10 YPKSPQSKDLIKEAILDNDFM-----KNLELSQIQEIVDCMYPVEYGKDS-CIIKEGDVG 63 Query: 392 TSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKE 451 + Y++ G V V G +CT+ G FG+LA++ + R A++ N +D++ Sbjct: 64 SLVYVMEDGKVEVTKEG-VKLCTMGPGKVFGELAILYNCTRTATVKTLV-NVKLWAIDRQ 121 Query: 452 DFNRIL 457 F I+ Sbjct: 122 CFQTIM 127 >2QCS-B nrPDB Length = 291 Score = 133 bits (334), Expect = 5e-31, Method: Composition-based stats. Identities = 48/189 (25%), Positives = 84/189 (44%), Gaps = 29/189 (15%) Query: 357 LSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLH 416 SHL + ++ + S G + QG+EG ++Y+I +G ++V + + ++ Sbjct: 47 FSHLDDNERSDIFDAMFPVSFI-AGETVIQQGDEGDNFYVIDQGEMDVYVNNEWAT-SVG 104 Query: 417 EGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHD---QD 473 EG FG+LAL+ PRAA++ + N +D++ + RIL + + + K ++ Sbjct: 105 EGGSFGELALIYGTPRAATVKAK-TNVKLWGIDRDSYRRIL--MGSTLRKRKMYEEFLSK 161 Query: 474 VLVLEKVPAGNRAANQGNSQPQQ----KYTVMSGTPEK----IL-------------EHF 512 V +LE + R +P Q + V+ G P IL E F Sbjct: 162 VSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENEEF 221 Query: 513 LETIRLEPS 521 +E RL PS Sbjct: 222 VEVGRLGPS 230 Score = 112 bits (281), Expect = 5e-25, Method: Composition-based stats. Identities = 30/126 (23%), Positives = 58/126 (46%), Gaps = 13/126 (10%) Query: 38 LKGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSS 97 ++ F N I + + G T+ +QGD G N+Y + G +DV V+ + Sbjct: 41 IEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNEWA 100 Query: 98 HQDAVTICTLGIGTAFGE-SILDNTPRHATIVTRESSELLRIEQEDFKALWE-----KYR 151 ++G G +FGE +++ TPR AT+ + + +L I+++ ++ + K + Sbjct: 101 -------TSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRK 153 Query: 152 QYMAGL 157 Y L Sbjct: 154 MYEEFL 159 Score = 98.2 bits (243), Expect = 2e-20, Method: Composition-based stats. Identities = 39/159 (24%), Positives = 71/159 (44%), Gaps = 14/159 (8%) Query: 325 DAHMRMILRKPPGQRTVDDLEIIYDELLH-IKALSHLSTTVKRELAGVLIFESHAKGGTV 383 D++ R+++ +R +Y+E L + L L + +A L + G Sbjct: 138 DSYRRILMGSTLRKRK------MYEEFLSKVSILESLDKWERLTVADALEPVQF-EDGQK 190 Query: 384 LFNQGEEGTSWYIILKGSVNVVIY---GKGVVCT--LHEGDDFGKLALVNDAPRAASIVL 438 + QGE G ++IIL+GS V+ + V L D FG++AL+ + P+AA++V Sbjct: 191 IVVQGEPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPKAATVVA 250 Query: 439 REDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVL 477 R +++D+ F R+L R + + L Sbjct: 251 RGP-LKCVKLDRPRFERVLGPCSDILKRNIQQYNSFVSL 288 Score = 78.6 bits (192), Expect = 1e-14, Method: Composition-based stats. Identities = 27/111 (24%), Positives = 49/111 (44%), Gaps = 2/111 (1%) Query: 38 LKGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSS 97 L V E + E G + QG+ G ++ +L GS V S Sbjct: 159 LSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRR-SE 217 Query: 98 HQDAVTICTLGIGTAFGE-SILDNTPRHATIVTRESSELLRIEQEDFKALW 147 +++ V + LG FGE ++L N P+ AT+V R + +++++ F+ + Sbjct: 218 NEEFVEVGRLGPSDYFGEIALLMNRPKAATVVARGPLKCVKLDRPRFERVL 268 >5JAX-A nrPDB Length = 135 Score = 132 bits (333), Expect = 5e-31, Method: Composition-based stats. Identities = 33/110 (30%), Positives = 53/110 (48%), Gaps = 2/110 (1%) Query: 38 LKGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSS 97 LK V F+ +L ++ + E G + RQG G ++ + G+++V E S Sbjct: 15 LKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTVNVT-REDSP 73 Query: 98 HQDAVTICTLGIGTAFGESILDNTP-RHATIVTRESSELLRIEQEDFKAL 146 +D V + TLG G FGE L R A ++ E+ L I+++ FK L Sbjct: 74 SEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVTCLVIDRDSFKHL 123 Score = 124 bits (312), Expect = 2e-28, Method: Composition-based stats. Identities = 33/121 (27%), Positives = 59/121 (48%), Gaps = 7/121 (5%) Query: 351 LLHIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKG 410 L + L + +LA VL E+H + G + QG G +++II KG+VNV Sbjct: 15 LKSVPTFQSLPEEILSKLADVLE-ETHYENGEYIIRQGARGDTFFIISKGTVNVTREDSP 73 Query: 411 -----VVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTV 465 + TL +GD FG+ AL + R A+++ E L +D++ F ++ ++ + Sbjct: 74 SEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEA-VTCLVIDRDSFKHLIGGLDDVSN 132 Query: 466 R 466 + Sbjct: 133 K 133 >4QX5-A nrPDB Length = 153 Score = 132 bits (333), Expect = 5e-31, Method: Composition-based stats. Identities = 33/110 (30%), Positives = 53/110 (48%), Gaps = 2/110 (1%) Query: 38 LKGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSS 97 LK V F+ +L ++ + E G + RQG G ++ + G+++V E S Sbjct: 15 LKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTVNVT-REDSP 73 Query: 98 HQDAVTICTLGIGTAFGESILDNTP-RHATIVTRESSELLRIEQEDFKAL 146 +D V + TLG G FGE L R A ++ E+ L I+++ FK L Sbjct: 74 SEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVTCLVIDRDSFKHL 123 Score = 125 bits (313), Expect = 1e-28, Method: Composition-based stats. Identities = 34/124 (27%), Positives = 60/124 (48%), Gaps = 7/124 (5%) Query: 351 LLHIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKG 410 L + L + +LA VL E+H + G + QG G +++II KG+VNV Sbjct: 15 LKSVPTFQSLPEEILSKLADVLE-ETHYENGEYIIRQGARGDTFFIISKGTVNVTREDSP 73 Query: 411 -----VVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTV 465 + TL +GD FG+ AL + R A+++ E L +D++ F ++ ++ + Sbjct: 74 SEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEA-VTCLVIDRDSFKHLIGGLDDVSN 132 Query: 466 RLKE 469 + E Sbjct: 133 KAYE 136 >5FET-A nrPDB Length = 847 Score = 132 bits (332), Expect = 7e-31, Method: Composition-based stats. Identities = 30/128 (23%), Positives = 64/128 (50%), Gaps = 8/128 (6%) Query: 25 ERSSEDVDIIFTRLKGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVL 84 E+ SED+++I LK + N + + + + G + +QG+ G+ ++ + Sbjct: 34 EKLSEDIEMIKASLKNNLVCSTLNDNEILTLSNYMQFFVFKGGDLVIKQGEKGSYFFIIN 93 Query: 85 AGSLDVKVSETSSHQDAVTICTLGIGTAFGE-SILDNTPRHATIVTRESSELLRIEQEDF 143 +G DV V++ + ++G G++FGE +++ NT R ATI+ L +++ F Sbjct: 94 SGKFDVYVNDK-------KVKSMGKGSSFGEAALIHNTQRSATIMAETDGTLWGVQRSTF 146 Query: 144 KALWEKYR 151 +A ++ Sbjct: 147 RATLKQLS 154 Score = 113 bits (282), Expect = 5e-25, Method: Composition-based stats. Identities = 37/126 (29%), Positives = 58/126 (46%), Gaps = 4/126 (3%) Query: 351 LLHIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKG 410 + + +LS L + + G + +GE G+ +YII G V V GK Sbjct: 407 IKKMYIFRYLSEQQCNLLIEAFRT-TRYEEGDYIIQEGEVGSRFYIIKNGEVEVTKNGK- 464 Query: 411 VVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRD--VEANTVRLK 468 + TL + D FG+ AL+ D PR ASI+ + + VDK F +I++ + R+K Sbjct: 465 RLRTLGKNDYFGERALLYDEPRTASIISKATSVECWFVDKSVFLQIIQGPMLTHLEERIK 524 Query: 469 EHDQDV 474 D V Sbjct: 525 MQDTKV 530 Score = 89.8 bits (221), Expect = 5e-18, Method: Composition-based stats. Identities = 33/123 (26%), Positives = 63/123 (51%), Gaps = 3/123 (2%) Query: 338 QRTVDDLEIIYDELLHIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYII 397 ++ +D+E+I L + S L+ L+ + F KGG ++ QGE+G+ ++II Sbjct: 34 EKLSEDIEMIKASLKNNLVCSTLNDNEILTLSNYMQF-FVFKGGDLVIKQGEKGSYFFII 92 Query: 398 LKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRIL 457 G +V + K V ++ +G FG+ AL+++ R+A+I+ D V + F L Sbjct: 93 NSGKFDVYVNDK-KVKSMGKGSSFGEAALIHNTQRSATIMAETDG-TLWGVQRSTFRATL 150 Query: 458 RDV 460 + + Sbjct: 151 KQL 153 Score = 85.1 bits (209), Expect = 1e-16, Method: Composition-based stats. Identities = 23/113 (20%), Positives = 51/113 (45%), Gaps = 9/113 (7%) Query: 38 LKGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSS 97 +K + F + E+G + ++G++G+ +Y + G ++V + Sbjct: 407 IKKMYIFRYLSEQQCNLLIEAFRTTRYEEGDYIIQEGEVGSRFYIIKNGEVEVTKNGK-- 464 Query: 98 HQDAVTICTLGIGTAFGE-SILDNTPRHATIVTR-ESSELLRIEQEDFKALWE 148 + TLG FGE ++L + PR A+I+++ S E +++ F + + Sbjct: 465 -----RLRTLGKNDYFGERALLYDEPRTASIISKATSVECWFVDKSVFLQIIQ 512 Score = 81.7 bits (200), Expect = 2e-15, Method: Composition-based stats. Identities = 30/143 (20%), Positives = 60/143 (41%), Gaps = 3/143 (2%) Query: 329 RMILRKPPGQRTVDDLEIIYDELLHIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQG 388 R R Q + + + + L+ K + + + K G + QG Sbjct: 143 RSTFRATLKQLSNRNFNENRSFIDSVSVFDMLTEAQKNMITNACVIQMF-KPGETIVKQG 201 Query: 389 EEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRV 448 + G +I+ +G V I K + L++G FG+ AL+ D PR+A+I+ +E + Sbjct: 202 DYGDVLFILKEGKATVFINDK-EIRVLNKGSYFGERALLYDEPRSATIIAKEPTA-CASI 259 Query: 449 DKEDFNRILRDVEANTVRLKEHD 471 ++ N +L +++ R + Sbjct: 260 CRKLLNIVLGNLQVVLFRNIMTE 282 Score = 75.1 bits (183), Expect = 1e-13, Method: Composition-based stats. Identities = 25/113 (22%), Positives = 46/113 (40%), Gaps = 8/113 (7%) Query: 40 GVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQ 99 V F+ I + + G T+ +QGD G + + G V +++ Sbjct: 167 SVSVFDMLTEAQKNMITNACVIQMFKPGETIVKQGDYGDVLFILKEGKATVFINDKE--- 223 Query: 100 DAVTICTLGIGTAFGE-SILDNTPRHATIVTRESSELLRIEQEDFKALWEKYR 151 I L G+ FGE ++L + PR ATI+ +E + I ++ + + Sbjct: 224 ----IRVLNKGSYFGERALLYDEPRSATIIAKEPTACASICRKLLNIVLGNLQ 272 Score = 35.1 bits (79), Expect = 0.14, Method: Composition-based stats. Identities = 24/135 (17%), Positives = 49/135 (36%), Gaps = 3/135 (2%) Query: 346 IIYDELLHIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVV 405 I+ + L + S +LA I + +L + + I+L+G V + Sbjct: 279 IMTEALQQSEIFRQFSAEQLNDLADTAIVRDYPANYHILHKDKVKSVKYLIVLEGKVELF 338 Query: 406 IYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTV 465 + + + L G FG ++N + V D C + + L D N Sbjct: 339 LDDESIG-ILTRGKSFGDQYVLNQKQKFRHTVKSLDVCKIALITESCLADCLGD--NNID 395 Query: 466 RLKEHDQDVLVLEKV 480 +H+ +++K+ Sbjct: 396 ASIDHNNKKSIIKKM 410 >2D93-A nrPDB Length = 134 Score = 132 bits (332), Expect = 8e-31, Method: Composition-based stats. Identities = 36/113 (31%), Positives = 64/113 (56%), Gaps = 2/113 (1%) Query: 350 ELLH-IKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYG 408 E +H + A ++++ +V+REL V+IFE + G ++ G+E SWY+IL G+V + + Sbjct: 16 EFMHQLPAFANMTMSVRRELCSVMIFEVVEQAGAIILEDGQELDSWYVILNGTVEIS-HP 74 Query: 409 KGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVE 461 G V L G+ FG ++ + + D+C F+ + ++D+ RIL VE Sbjct: 75 DGKVENLFMGNSFGITPTLDKQYMHGIVRTKVDDCQFVCIAQQDYWRILNHVE 127 Score = 45.1 bits (105), Expect = 2e-04, Method: Composition-based stats. Identities = 25/125 (20%), Positives = 57/125 (45%), Gaps = 10/125 (8%) Query: 31 VDIIFTRLKGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQ-GDIGTNWYAVLAGSLD 89 ++ + + + AF ++ R++C +E +E+ + + G +WY +L G+++ Sbjct: 11 IEQLLEFMHQLPAFANMTMSVRRELCSVMIFEVVEQAGAIILEDGQELDSWYVILNGTVE 70 Query: 90 VKVSETSSHQDAVTICTLGIGTAFG-ESILDNTPRHATIVTR-ESSELLRIEQEDFKALW 147 + SH D + L +G +FG LD H + T+ + + + I Q+D+ + Sbjct: 71 I------SHPDG-KVENLFMGNSFGITPTLDKQYMHGIVRTKVDDCQFVCIAQQDYWRIL 123 Query: 148 EKYRQ 152 + Sbjct: 124 NHVEK 128 >6BQ8-A nrPDB Length = 152 Score = 131 bits (330), Expect = 1e-30, Method: Composition-based stats. Identities = 35/127 (27%), Positives = 61/127 (48%), Gaps = 6/127 (4%) Query: 38 LKGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSS 97 L+ V + + L +I C E +KG + R+G+ G+ ++ + G + V S T Sbjct: 15 LRSVSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQS-TEG 73 Query: 98 HQDAVTICTLGIGTAFGE-SILDNTPRHATIVTRE-SSELLRIEQEDFK---ALWEKYRQ 152 H I TL G FGE +++ + R A I+ E L I++E F +E+ ++ Sbjct: 74 HDQPQLIKTLQKGEYFGEKALISDDVRSANIIAEENDVACLVIDRETFNQTVGTFEELQK 133 Query: 153 YMAGLLA 159 Y+ G +A Sbjct: 134 YLEGYVA 140 Score = 112 bits (280), Expect = 8e-25, Method: Composition-based stats. Identities = 36/132 (27%), Positives = 68/132 (51%), Gaps = 7/132 (5%) Query: 345 EIIYDELL-HIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVN 403 + Y L + L +L ++ L E + G + +GEEG++++I+ KG V Sbjct: 8 DEQYRNFLRSVSLLKNLPEDKLTKIIDCLEVE-YYDKGDYIIREGEEGSTFFILAKGKVK 66 Query: 404 VVIYGKG-----VVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILR 458 V +G ++ TL +G+ FG+ AL++D R+A+I+ E++ L +D+E FN+ + Sbjct: 67 VTQSTEGHDQPQLIKTLQKGEYFGEKALISDDVRSANIIAEENDVACLVIDRETFNQTVG 126 Query: 459 DVEANTVRLKEH 470 E L+ + Sbjct: 127 TFEELQKYLEGY 138 >6BYS-B nrPDB Length = 379 Score = 129 bits (325), Expect = 4e-30, Method: Composition-based stats. Identities = 48/189 (25%), Positives = 84/189 (44%), Gaps = 29/189 (15%) Query: 357 LSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLH 416 SHL + ++ + S G + QG+EG ++Y+I +G ++V + + ++ Sbjct: 136 FSHLDDNERSDIFDAMFPVSFI-AGETVIQQGDEGDNFYVIDQGEMDVYVNNEWAT-SVG 193 Query: 417 EGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHD---QD 473 EG FG+LAL+ PRAA++ + N +D++ + RIL + + + K ++ Sbjct: 194 EGGSFGELALIYGTPRAATVKAK-TNVKLWGIDRDSYRRIL--MGSTLRKRKMYEEFLSK 250 Query: 474 VLVLEKVPAGNRAANQGNSQPQQ----KYTVMSGTPEK----IL-------------EHF 512 V +LE + R +P Q + V+ G P IL E F Sbjct: 251 VSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENEEF 310 Query: 513 LETIRLEPS 521 +E RL PS Sbjct: 311 VEVGRLGPS 319 Score = 110 bits (275), Expect = 3e-24, Method: Composition-based stats. Identities = 30/126 (23%), Positives = 58/126 (46%), Gaps = 13/126 (10%) Query: 38 LKGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSS 97 ++ F N I + + G T+ +QGD G N+Y + G +DV V+ + Sbjct: 130 IEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNEWA 189 Query: 98 HQDAVTICTLGIGTAFGE-SILDNTPRHATIVTRESSELLRIEQEDFKALWE-----KYR 151 ++G G +FGE +++ TPR AT+ + + +L I+++ ++ + K + Sbjct: 190 -------TSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRK 242 Query: 152 QYMAGL 157 Y L Sbjct: 243 MYEEFL 248 Score = 97.9 bits (242), Expect = 2e-20, Method: Composition-based stats. Identities = 40/159 (25%), Positives = 71/159 (44%), Gaps = 14/159 (8%) Query: 325 DAHMRMILRKPPGQRTVDDLEIIYDELLH-IKALSHLSTTVKRELAGVLIFESHAKGGTV 383 D++ R+++ +R +Y+E L + L L + +A L + G Sbjct: 227 DSYRRILMGSTLRKRK------MYEEFLSKVSILESLDKWERLTVADALEPVQF-EDGQK 279 Query: 384 LFNQGEEGTSWYIILKGSVNVVIY---GKGVVCT--LHEGDDFGKLALVNDAPRAASIVL 438 + QGE G ++IIL+GS V+ + V L D FG++AL+ + PRAA++V Sbjct: 280 IVVQGEPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVA 339 Query: 439 REDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVL 477 R +++D+ F R+L R + + L Sbjct: 340 RGP-LKCVKLDRPRFERVLGPCSDILKRNIQQYNSFVSL 377 Score = 79.0 bits (193), Expect = 9e-15, Method: Composition-based stats. Identities = 28/111 (25%), Positives = 49/111 (44%), Gaps = 2/111 (1%) Query: 38 LKGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSS 97 L V E + E G + QG+ G ++ +L GS V S Sbjct: 248 LSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRR-SE 306 Query: 98 HQDAVTICTLGIGTAFGE-SILDNTPRHATIVTRESSELLRIEQEDFKALW 147 +++ V + LG FGE ++L N PR AT+V R + +++++ F+ + Sbjct: 307 NEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVL 357 >4DIN-B nrPDB Length = 381 Score = 129 bits (324), Expect = 7e-30, Method: Composition-based stats. Identities = 40/156 (25%), Positives = 75/156 (48%), Gaps = 12/156 (7%) Query: 357 LSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLH 416 +HL + ++ + +H G + QG EG ++Y++ +G V+V + G+ V + Sbjct: 138 FAHLDDNERSDIFDAMFPVTHI-AGETVIQQGNEGDNFYVVDQGEVDVYVNGEWVT-NIS 195 Query: 417 EGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHD---QD 473 EG FG+LAL+ PRAA++ + D +D++ + RIL + + + K ++ Sbjct: 196 EGGSFGELALIYGTPRAATVKAKTD-LKLWGIDRDSYRRIL--MGSTLRKRKMYEEFLSK 252 Query: 474 VLVLEKVPAGNRAANQGNSQPQQ----KYTVMSGTP 505 V +LE + R +P Q + V+ G P Sbjct: 253 VSILESLEKWERLTVADALEPVQFEDGEKIVVQGEP 288 Score = 103 bits (257), Expect = 4e-22, Method: Composition-based stats. Identities = 29/121 (23%), Positives = 52/121 (42%), Gaps = 13/121 (10%) Query: 43 AFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAV 102 F N I + G T+ +QG+ G N+Y V G +DV V+ Sbjct: 137 LFAHLDDNERSDIFDAMFPVTHIAGETVIQQGNEGDNFYVVDQGEVDVYVNGEW------ 190 Query: 103 TICTLGIGTAFGE-SILDNTPRHATIVTRESSELLRIEQEDFKALWE-----KYRQYMAG 156 + + G +FGE +++ TPR AT+ + +L I+++ ++ + K + Y Sbjct: 191 -VTNISEGGSFGELALIYGTPRAATVKAKTDLKLWGIDRDSYRRILMGSTLRKRKMYEEF 249 Query: 157 L 157 L Sbjct: 250 L 250 Score = 100 bits (249), Expect = 4e-21, Method: Composition-based stats. Identities = 39/159 (24%), Positives = 70/159 (44%), Gaps = 14/159 (8%) Query: 325 DAHMRMILRKPPGQRTVDDLEIIYDELLH-IKALSHLSTTVKRELAGVLIFESHAKGGTV 383 D++ R+++ +R +Y+E L + L L + +A L + G Sbjct: 229 DSYRRILMGSTLRKRK------MYEEFLSKVSILESLEKWERLTVADALEPVQF-EDGEK 281 Query: 384 LFNQGEEGTSWYIILKGSVNVVIYGKG-----VVCTLHEGDDFGKLALVNDAPRAASIVL 438 + QGE G +YII +G+ +V+ V L D FG++AL+ + PRAA++V Sbjct: 282 IVVQGEPGDDFYIITEGTASVLQRRSPNEEYVEVGRLGPSDYFGEIALLLNRPRAATVVA 341 Query: 439 REDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVL 477 R +++D+ F R+L R + + L Sbjct: 342 RGP-LKCVKLDRPRFERVLGPCSEILKRNIQRYNSFISL 379 Score = 80.5 bits (197), Expect = 3e-15, Method: Composition-based stats. Identities = 27/111 (24%), Positives = 49/111 (44%), Gaps = 2/111 (1%) Query: 38 LKGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSS 97 L V E + E G + QG+ G ++Y + G+ V S Sbjct: 250 LSKVSILESLEKWERLTVADALEPVQFEDGEKIVVQGEPGDDFYIITEGTASVLQRR-SP 308 Query: 98 HQDAVTICTLGIGTAFGE-SILDNTPRHATIVTRESSELLRIEQEDFKALW 147 +++ V + LG FGE ++L N PR AT+V R + +++++ F+ + Sbjct: 309 NEEYVEVGRLGPSDYFGEIALLLNRPRAATVVARGPLKCVKLDRPRFERVL 359 >3J4Q-B nrPDB Length = 402 Score = 127 bits (318), Expect = 3e-29, Method: Composition-based stats. Identities = 47/210 (22%), Positives = 91/210 (43%), Gaps = 34/210 (16%) Query: 294 REDAPLPTEEEKKECDEELQDTMLLL--------------SQMGPDAHM-----RMILRK 334 +E + +P EE E D + +D L + PD R++ K Sbjct: 61 QESSAVPVIEEDGESDSDSEDADLEVPVPSKFTRRVSVCAETFNPDEEEEDNDPRVVHPK 120 Query: 335 PPGQRTVDDLEIIYDELLHIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSW 394 QR L+ ++L +L ++ + FE K + +QG++G ++ Sbjct: 121 TDEQRC--RLQEACKDILL---FKNLDQEQLSQVLDAM-FEKIVKTDEHVIDQGDDGDNF 174 Query: 395 YIILKGSVNVVIYGKGVVCTLHEGD---DFGKLALVNDAPRAASIVLREDNCHFLRVDKE 451 Y+I +G+ ++++ ++ + D FG+LAL+ + PRAA+I+ + +D+ Sbjct: 175 YVIERGTYDILVTKDNQTRSVGQYDNRGSFGELALMYNTPRAATIIATSEG-SLWGLDRV 233 Query: 452 DFNRILRDVEANTVRLKEHDQDVLVLEKVP 481 F RI+ V+ N + K + +E VP Sbjct: 234 TFRRII--VKNNAKKRKMFES---FIESVP 258 Score = 117 bits (294), Expect = 2e-26, Method: Composition-based stats. Identities = 45/174 (25%), Positives = 75/174 (43%), Gaps = 26/174 (14%) Query: 329 RMILRKPPGQRTVDDLEIIYDELL-HIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQ 387 R+I++ +R +++ + + L + + ++ V I E K G + Q Sbjct: 237 RIIVKNNAKKRK------MFESFIESVPLFKSLEMSERMKIVDV-IGEKIYKDGERIIAQ 289 Query: 388 GEEGTSWYIILKGSVNVVIYGKGV-----------VCTLHEGDDFGKLALVNDAPRAASI 436 GE+ S+YII G V+++I K + H+G FG+LALV + PRAAS Sbjct: 290 GEKADSFYIIESGEVSILIRSKTKSNKNGGNQEVEIAHCHKGQYFGELALVTNKPRAASA 349 Query: 437 VLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLV------LEKVPAGN 484 D L +D + F R+L R H ++ LV L+ + G Sbjct: 350 YAVGD-VKCLVMDVQAFERLLGPCMDIMKRNISHYEEQLVKMFGSNLDLMDPGQ 402 Score = 86.3 bits (212), Expect = 6e-17, Method: Composition-based stats. Identities = 27/129 (20%), Positives = 59/129 (45%), Gaps = 9/129 (6%) Query: 39 KGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSH 98 K + F+ L Q+ + + ++ + QGD G N+Y + G+ D+ V++ Sbjct: 133 KDILLFKNLDQEQLSQVLDAMFEKIVKTDEHVIDQGDDGDNFYVIERGTYDILVTKD--- 189 Query: 99 QDAVTICTLGIGTAFGE-SILDNTPRHATIVTRESSELLRIEQEDFKALW-----EKYRQ 152 ++ +FGE +++ NTPR ATI+ L +++ F+ + +K + Sbjct: 190 NQTRSVGQYDNRGSFGELALMYNTPRAATIIATSEGSLWGLDRVTFRRIIVKNNAKKRKM 249 Query: 153 YMAGLLAPP 161 + + + + P Sbjct: 250 FESFIESVP 258 Score = 80.9 bits (198), Expect = 3e-15, Method: Composition-based stats. Identities = 22/121 (18%), Positives = 50/121 (41%), Gaps = 6/121 (4%) Query: 33 IIFTRLKGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKV 92 + + ++ V F+ + +I + + G + QG+ ++Y + +G + + + Sbjct: 249 MFESFIESVPLFKSLEMSERMKIVDVIGEKIYKDGERIIAQGEKADSFYIIESGEVSILI 308 Query: 93 -----SETSSHQDAVTICTLGIGTAFGE-SILDNTPRHATIVTRESSELLRIEQEDFKAL 146 S + V I G FGE +++ N PR A+ + L ++ + F+ L Sbjct: 309 RSKTKSNKNGGNQEVEIAHCHKGQYFGELALVTNKPRAASAYAVGDVKCLVMDVQAFERL 368 Query: 147 W 147 Sbjct: 369 L 369 >2QVS-B nrPDB Length = 310 Score = 126 bits (317), Expect = 4e-29, Method: Composition-based stats. Identities = 38/160 (23%), Positives = 76/160 (47%), Gaps = 15/160 (9%) Query: 325 DAHMRMILRKPPGQRTVDDLEIIYDELLHIKALSHLSTTVKRELAGVLIFESHAKGGTVL 384 D R++ K QR L+ ++L +L ++ + FE K + Sbjct: 19 DNDPRVVHPKTDEQRC--RLQEACKDILL---FKNLDQEQLSQVLDAM-FEKIVKTDEHV 72 Query: 385 FNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGD---DFGKLALVNDAPRAASIVLRED 441 +QG++G ++Y+I +G+ ++++ ++ + D FG+LAL+ + PRAA+I+ + Sbjct: 73 IDQGDDGDNFYVIERGTYDILVTKDNQTRSVGQYDNRGSFGELALMYNTPRAATIIATSE 132 Query: 442 NCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVP 481 +D+ F RI+ V+ N + K + +E VP Sbjct: 133 G-SLWGLDRVTFRRII--VKNNAKKRKMFES---FIESVP 166 Score = 118 bits (295), Expect = 1e-26, Method: Composition-based stats. Identities = 45/174 (25%), Positives = 75/174 (43%), Gaps = 26/174 (14%) Query: 329 RMILRKPPGQRTVDDLEIIYDELL-HIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQ 387 R+I++ +R +++ + + L + + ++ V I E K G + Q Sbjct: 145 RIIVKNNAKKRK------MFESFIESVPLFKSLEMSERMKIVDV-IGEKIYKDGERIIAQ 197 Query: 388 GEEGTSWYIILKGSVNVVIYGKGV-----------VCTLHEGDDFGKLALVNDAPRAASI 436 GE+ S+YII G V+++I K + H+G FG+LALV + PRAAS Sbjct: 198 GEKADSFYIIESGEVSILIRSKTKSNKNGGNQEVEIAHCHKGQYFGELALVTNKPRAASA 257 Query: 437 VLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLV------LEKVPAGN 484 D L +D + F R+L R H ++ LV L+ + G Sbjct: 258 YGVGD-VKCLVMDVQAFERLLGPCMDIMKRNISHYEEQLVKMFGSNLDLMDPGQ 310 Score = 87.5 bits (215), Expect = 3e-17, Method: Composition-based stats. Identities = 27/129 (20%), Positives = 59/129 (45%), Gaps = 9/129 (6%) Query: 39 KGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSH 98 K + F+ L Q+ + + ++ + QGD G N+Y + G+ D+ V++ Sbjct: 41 KDILLFKNLDQEQLSQVLDAMFEKIVKTDEHVIDQGDDGDNFYVIERGTYDILVTKD--- 97 Query: 99 QDAVTICTLGIGTAFGE-SILDNTPRHATIVTRESSELLRIEQEDFKALW-----EKYRQ 152 ++ +FGE +++ NTPR ATI+ L +++ F+ + +K + Sbjct: 98 NQTRSVGQYDNRGSFGELALMYNTPRAATIIATSEGSLWGLDRVTFRRIIVKNNAKKRKM 157 Query: 153 YMAGLLAPP 161 + + + + P Sbjct: 158 FESFIESVP 166 Score = 80.5 bits (197), Expect = 4e-15, Method: Composition-based stats. Identities = 22/121 (18%), Positives = 50/121 (41%), Gaps = 6/121 (4%) Query: 33 IIFTRLKGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKV 92 + + ++ V F+ + +I + + G + QG+ ++Y + +G + + + Sbjct: 157 MFESFIESVPLFKSLEMSERMKIVDVIGEKIYKDGERIIAQGEKADSFYIIESGEVSILI 216 Query: 93 -----SETSSHQDAVTICTLGIGTAFGE-SILDNTPRHATIVTRESSELLRIEQEDFKAL 146 S + V I G FGE +++ N PR A+ + L ++ + F+ L Sbjct: 217 RSKTKSNKNGGNQEVEIAHCHKGQYFGELALVTNKPRAASAYGVGDVKCLVMDVQAFERL 276 Query: 147 W 147 Sbjct: 277 L 277 >5J3U-A nrPDB Length = 261 Score = 126 bits (317), Expect = 4e-29, Method: Composition-based stats. Identities = 44/162 (27%), Positives = 73/162 (45%), Gaps = 15/162 (9%) Query: 331 ILRKPPGQRTVDDLEIIYDELLHIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEE 390 + K GQ+ + LE I + +L + + E + T L +G++ Sbjct: 1 VYEKDEGQK--EQLERILRQSFLFNSLDEKDLNT----VILAMQEKKIEASTCLIREGDD 54 Query: 391 GTSWYIILKGSVNVVIYGKG---VVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLR 447 G YI+ G +N G VV + GD FG+LAL+ +APRAA++ C Sbjct: 55 GECLYIVQSGELNCSKLIDGEERVVKVVGPGDAFGELALLYNAPRAATV-TSVSACDLWE 113 Query: 448 VDKEDFNRILRDVEANTVRLKEHD---QDVLVLEKVPAGNRA 486 + ++ FN I++D A T R +D + V +L+ + A R Sbjct: 114 LGRDTFNAIVKD--AATKRRSMYDSFLKSVHILDGMDAYERG 153 Score = 115 bits (288), Expect = 9e-26, Method: Composition-based stats. Identities = 31/110 (28%), Positives = 53/110 (48%), Gaps = 4/110 (3%) Query: 38 LKGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSS 97 L+ F L + L + +E L R+GD G Y V +G L+ S+ Sbjct: 16 LRQSFLFNSLDEKDLNTVILAMQEKKIEASTCLIREGDDGECLYIVQSGELNC--SKLID 73 Query: 98 HQDAVTICTLGIGTAFGE-SILDNTPRHATIVTRESSELLRIEQEDFKAL 146 ++ V + +G G AFGE ++L N PR AT+ + + +L + ++ F A+ Sbjct: 74 GEERV-VKVVGPGDAFGELALLYNAPRAATVTSVSACDLWELGRDTFNAI 122 Score = 107 bits (266), Expect = 4e-23, Method: Composition-based stats. Identities = 37/159 (23%), Positives = 67/159 (42%), Gaps = 14/159 (8%) Query: 319 LSQMGPDAHMRMILRKPPGQRTVDDLEIIYDELL-HIKALSHLSTTVKRELAGVLIFESH 377 L ++G D ++ +R+ +YD L + L + + ++A L E Sbjct: 111 LWELGRDTFNAIVKDAATKRRS------MYDSFLKSVHILDGMDAYERGKVADALRTEMF 164 Query: 378 AKGGTVLFNQGEEGTSWYIILKGSVNVVIY-----GKGVVCTLHEGDDFGKLALVNDAPR 432 G + QGE G +YI+ +GS V GD FG+LAL+N+ PR Sbjct: 165 T-DGAYIVRQGELGDVFYIVEEGSAVATKSFGPGQPPIEVKKYQAGDYFGELALINEEPR 223 Query: 433 AASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHD 471 AA+++ C ++++ F R++ V+ + Sbjct: 224 AANVIAHG-ICKVACLERKSFKRLMGSVQDLLSKKASEY 261 Score = 81.3 bits (199), Expect = 2e-15, Method: Composition-based stats. Identities = 26/119 (21%), Positives = 49/119 (41%), Gaps = 2/119 (1%) Query: 38 LKGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSS 97 LK V + ++ E G + RQG++G +Y V GS V Sbjct: 138 LKSVHILDGMDAYERGKVADALRTEMFTDGAYIVRQGELGDVFYIVEEGSA-VATKSFGP 196 Query: 98 HQDAVTICTLGIGTAFGE-SILDNTPRHATIVTRESSELLRIEQEDFKALWEKYRQYMA 155 Q + + G FGE ++++ PR A ++ ++ +E++ FK L + ++ Sbjct: 197 GQPPIEVKKYQAGDYFGELALINEEPRAANVIAHGICKVACLERKSFKRLMGSVQDLLS 255 >6CJQ-A nrPDB Length = 456 Score = 114 bits (286), Expect = 2e-25, Method: Composition-based stats. Identities = 47/159 (29%), Positives = 69/159 (43%), Gaps = 11/159 (6%) Query: 327 HMRMILRKPPGQ-RTVDDLEIIYDELLHIKALSHLSTTVKRELAGVLIFESHAKGGTVLF 385 R +L++ P R +EI D + + R++ L G + Sbjct: 290 EEREVLKELPHPLRLAVAMEIHGDVIEKVPLFKGAGEEFIRDIILHLEP-VIYGPGEYII 348 Query: 386 NQGEEGTSWYIILKGSVNVVIYG-KGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCH 444 GE G+ Y I +GSV V+ K L EG FG++AL+ APR A++ R C Sbjct: 349 RAGEMGSDVYFINRGSVEVLSADEKTRYAILSEGQFFGEMALILRAPRTATVRARA-FCD 407 Query: 445 FLRVDKEDFNRILR-------DVEANTVRLKEHDQDVLV 476 R+DKE F+RIL ++ VR KE + LV Sbjct: 408 LYRLDKETFDRILSRYPEIAAQIQELAVRRKELESSGLV 446 Score = 85.1 bits (209), Expect = 1e-16, Method: Composition-based stats. Identities = 31/128 (24%), Positives = 58/128 (45%), Gaps = 6/128 (4%) Query: 26 RSSEDVDIIFTRLKGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLA 85 R + ++I ++ V F+ +R I L G + R G++G++ Y + Sbjct: 303 RLAVAMEIHGDVIEKVPLFKGAGEEFIRDIILHLEPVIYGPGEYIIRAGEMGSDVYFINR 362 Query: 86 GSLDVKVSETSSHQDAVTICTLGIGTAFGE-SILDNTPRHATIVTRESSELLRIEQEDFK 144 GS++V S + L G FGE +++ PR AT+ R +L R+++E F Sbjct: 363 GSVEVL-----SADEKTRYAILSEGQFFGEMALILRAPRTATVRARAFCDLYRLDKETFD 417 Query: 145 ALWEKYRQ 152 + +Y + Sbjct: 418 RILSRYPE 425 >5V4S-A nrPDB Length = 465 Score = 99.4 bits (246), Expect = 7e-21, Method: Composition-based stats. Identities = 39/146 (26%), Positives = 68/146 (46%), Gaps = 6/146 (4%) Query: 335 PPGQRTVDDLEIIYDELLHIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSW 394 P R +++ D L + L + L + + G +F +GE+G Sbjct: 324 PISLRREVKIQLHRDLLEKVPFLKGADPALVTSLVFSMKPMIFLE-GDTIFRRGEKGDDL 382 Query: 395 YIILKGSVNVVIYG-KGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDF 453 YI+ +GSV+++ K ++ +L EG FG+LALV DAPR+A++ C + K DF Sbjct: 383 YILSEGSVDILDSDEKTILLSLQEGQFFGELALVMDAPRSATVRA-TTTCEIYTLSKTDF 441 Query: 454 NRILRDVEANTVRLKEHDQDVLVLEK 479 + +L+ ++ V L+K Sbjct: 442 DNVLKRFSQF---RSAIEESVAHLKK 464 Score = 79.7 bits (195), Expect = 5e-15, Method: Composition-based stats. Identities = 31/139 (22%), Positives = 64/139 (46%), Gaps = 7/139 (5%) Query: 17 ACLDKRPLE-RSSEDVDIIFTRLKGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGD 75 A L+ P+ R + + L+ V + P L+ + +G T+FR+G+ Sbjct: 318 ALLNDLPISLRREVKIQLHRDLLEKVPFLKGADPALVTSLVFSMKPMIFLEGDTIFRRGE 377 Query: 76 IGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGE-SILDNTPRHATIVTRESSE 134 G + Y + GS+D+ + + +L G FGE +++ + PR AT+ + E Sbjct: 378 KGDDLYILSEGSVDIL-----DSDEKTILLSLQEGQFFGELALVMDAPRSATVRATTTCE 432 Query: 135 LLRIEQEDFKALWEKYRQY 153 + + + DF + +++ Q+ Sbjct: 433 IYTLSKTDFDNVLKRFSQF 451 >4EV0-A nrPDB Length = 216 Score = 99.0 bits (245), Expect = 9e-21, Method: Composition-based stats. Identities = 36/114 (31%), Positives = 52/114 (45%), Gaps = 3/114 (2%) Query: 38 LKGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSS 97 +KG F P + +G +F QGD+G Y V +G V++ T Sbjct: 1 MKGSPLFHGLAPEEVDLALSYFQRRLYPQGKPIFYQGDLGQALYLVASGK--VRLFRTHL 58 Query: 98 HQDAVTICTLGIGTAFGE-SILDNTPRHATIVTRESSELLRIEQEDFKALWEKY 150 T+ LG G FGE S+LD R A+ V E +ELL + +ED+ AL + Sbjct: 59 GGQERTLALLGPGELFGEMSLLDEGERSASAVAVEDTELLALFREDYLALIRRL 112 Score = 58.2 bits (139), Expect = 2e-08, Method: Composition-based stats. Identities = 26/115 (22%), Positives = 50/115 (43%), Gaps = 6/115 (5%) Query: 355 KALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIY----GKG 410 L+ +LA G +F QG+ G + Y++ G V + + Sbjct: 5 PLFHGLAPEEV-DLALSYFQRRLYPQGKPIFYQGDLGQALYLVASGKVRLFRTHLGGQER 63 Query: 411 VVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTV 465 + L G+ FG+++L+++ R+AS V ED L + +ED+ ++R + Sbjct: 64 TLALLGPGELFGEMSLLDEGERSASAVAVEDT-ELLALFREDYLALIRRLPLVAH 117 >6FTF-B nrPDB Length = 304 Score = 72.8 bits (177), Expect = 7e-13, Method: Composition-based stats. Identities = 38/146 (26%), Positives = 62/146 (42%), Gaps = 12/146 (8%) Query: 340 TVDDLEIIYDELL-HIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIIL 398 T Y + L ++ L L + K +LA L E G + + GEEG YII+ Sbjct: 148 TAIRRRETYIQFLANVPFLGGLDSYEKLQLADALSSEEF-SPGEYIIHYGEEGEWLYIIM 206 Query: 399 KGSVNVVIYGK----GVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFN 454 +G+V V+ VC +GD G+L +N+ R + V+ + ++++ F Sbjct: 207 EGTVEVIGRDADGEPTKVCEFTQGDHIGELEFLNNH-RTVADVVATTHVITAKLNRRHFE 265 Query: 455 RILRDVEANTVR-----LKEHDQDVL 475 L V R E+ Q+VL Sbjct: 266 MCLGPVIDVLKRCADDPKYEYYQNVL 291 Score = 72.0 bits (175), Expect = 1e-12, Method: Composition-based stats. Identities = 35/168 (20%), Positives = 70/168 (41%), Gaps = 10/168 (5%) Query: 323 GPDAHMRMILRKPPGQRTVDDLEIIYDELLHIKALSHLSTTVKRELAGVLIFESHAKGGT 382 G D + + P +++ D++ +I L H S L+T + +AG + + K Sbjct: 12 GIDPEKAKLYQAPYFEKSEDEMNLITKLLTHNVLFSFLNTKDIKVVAGAMQRATF-KHDD 70 Query: 383 VLFNQGEEG-TSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLRED 441 + G+ YII G +++ G+ V EG G+L L+ D P A++ + D Sbjct: 71 CIMEAGQTTCNKLYIIQSGHADIIKEGQKVYLK-TEGTAVGELELMYDTPVVATVKVCTD 129 Query: 442 NCHFLRVDKEDFNRILRDVEANTVRLKEHD----QDVLVLEKVPAGNR 485 +D++ + + V +R +E +V L + + + Sbjct: 130 ELIAWVLDRDTYRNL---VMGTAIRRRETYIQFLANVPFLGGLDSYEK 174 Score = 67.8 bits (164), Expect = 2e-11, Method: Composition-based stats. Identities = 25/149 (16%), Positives = 55/149 (36%), Gaps = 15/149 (10%) Query: 22 RPLERSSEDVDIIFTRLKGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTN-W 80 E+S +++++I L F + ++ + + + G N Sbjct: 24 PYFEKSEDEMNLITKLLTHNVLFSFLNTKDIKVVAGAMQRATFKHDDCIMEAGQTTCNKL 83 Query: 81 YAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGE-SILDNTPRHATIVTRESSEL-LRI 138 Y + +G D+ V + T GTA GE ++ +TP AT+ + + Sbjct: 84 YIIQSGHADI-----IKEGQKVYLKT--EGTAVGELELMYDTPVVATVKVCTDELIAWVL 136 Query: 139 EQEDFKALWE-----KYRQYMAGLLAPPY 162 +++ ++ L + Y+ L P+ Sbjct: 137 DRDTYRNLVMGTAIRRRETYIQFLANVPF 165 Score = 58.9 bits (141), Expect = 1e-08, Method: Composition-based stats. Identities = 19/108 (17%), Positives = 36/108 (33%), Gaps = 3/108 (2%) Query: 38 LKGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSS 97 L V Q+ E G + G+ G Y ++ G+++V + + Sbjct: 160 LANVPFLGGLDSYEKLQLADALSSEEFSPGEYIIHYGEEGEWLYIIMEGTVEVIGRD--A 217 Query: 98 HQDAVTICTLGIGTAFGESILDNTPRH-ATIVTRESSELLRIEQEDFK 144 + +C G GE N R A +V ++ + F+ Sbjct: 218 DGEPTKVCEFTQGDHIGELEFLNNHRTVADVVATTHVITAKLNRRHFE 265 >5JON-A nrPDB Length = 517 Score = 71.3 bits (173), Expect = 2e-12, Method: Composition-based stats. Identities = 24/107 (22%), Positives = 45/107 (42%), Gaps = 3/107 (2%) Query: 353 HIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVV 412 + ++ + L FE + G + +G G Y I G V+V+ G + Sbjct: 391 SMPLFANADPNFVTAMLTKLKFEVF-QPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKEM 449 Query: 413 CTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRD 459 L +G FG++ L+ R AS+ + C + ++FN +L + Sbjct: 450 K-LSDGSYFGEICLLTRGRRTASVRA-DTYCRLYSLSVDNFNEVLEE 494 Score = 64.7 bits (156), Expect = 2e-10, Method: Composition-based stats. Identities = 24/112 (21%), Positives = 43/112 (38%), Gaps = 8/112 (7%) Query: 40 GVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQ 99 + F PN + + +E + G + R+G IG Y + G + V + Sbjct: 391 SMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKEMK 450 Query: 100 DAVTICTLGIGTAFGE-SILDNTPRHATIVTRESSELLRIEQEDFKALWEKY 150 L G+ FGE +L R A++ L + ++F + E+Y Sbjct: 451 -------LSDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEY 495 >5U6P-A nrPDB Length = 660 Score = 70.9 bits (172), Expect = 3e-12, Method: Composition-based stats. Identities = 37/180 (20%), Positives = 70/180 (38%), Gaps = 8/180 (4%) Query: 354 IKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVC 413 + ++ + L FE + G + +G G Y I G V+ + Sbjct: 473 MPLFANADPNFVTAMLSKLRFEVF-QPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMK 531 Query: 414 TLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQD 473 L +G FG++ L+ R AS+ + C + ++FN +L E +R Sbjct: 532 -LTDGSYFGEICLLTKGRRTASVRA-DTYCRLYSLSVDNFNEVLE--EYPMMRRAFETVA 587 Query: 474 VLVLEKVPAGNRAANQGNSQPQQKYTVMSGTPEKILEHFLETIR--LEPSLNEATDSVLN 531 + L+++ N Q Q V + +IL+ ++ R ++ +L + SVLN Sbjct: 588 IDRLDRIGKKNSILLQ-KFQKDLNTGVFNNQENEILKQIVKHDREMVQAALPRESSSVLN 646 Score = 61.6 bits (148), Expect = 2e-09, Method: Composition-based stats. Identities = 23/112 (20%), Positives = 43/112 (38%), Gaps = 8/112 (7%) Query: 40 GVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQ 99 + F PN + + +E + G + R+G +G Y + G V + + Sbjct: 472 TMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMK 531 Query: 100 DAVTICTLGIGTAFGE-SILDNTPRHATIVTRESSELLRIEQEDFKALWEKY 150 L G+ FGE +L R A++ L + ++F + E+Y Sbjct: 532 -------LTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEVLEEY 576 >3I59-A nrPDB Length = 249 Score = 65.1 bits (157), Expect = 1e-10, Method: Composition-based stats. Identities = 21/104 (20%), Positives = 46/104 (44%), Gaps = 3/104 (2%) Query: 43 AFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAV 102 F+ P+ + + + +G T+F +G+ G Y +++G VK+ + Sbjct: 35 IFQGVEPSAIAALTKQLQPVDFPRGHTVFAEGEPGDRLYIIISGK--VKIGRRAPDGREN 92 Query: 103 TICTLGIGTAFGE-SILDNTPRHATIVTRESSELLRIEQEDFKA 145 + +G FGE SI D PR ++ T + ++++ ++ Sbjct: 93 LLTIMGPSDMFGELSIFDPGPRTSSATTITEVRAVSMDRDALRS 136 Score = 53.9 bits (128), Expect = 4e-07, Method: Composition-based stats. Identities = 21/113 (18%), Positives = 43/113 (38%), Gaps = 6/113 (5%) Query: 356 ALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYG----KGV 411 + + L L + G +F +GE G YII+ G V + + + Sbjct: 35 IFQGVEPSAIAALTKQLQPVDFPR-GHTVFAEGEPGDRLYIIISGKVKIGRRAPDGRENL 93 Query: 412 VCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANT 464 + + D FG+L++ + PR +S + +D++ + D + Sbjct: 94 LTIMGPSDMFGELSIFDPGPRTSSA-TTITEVRAVSMDRDALRSWIADRPEIS 145 >4CHV-A nrPDB Length = 361 Score = 64.7 bits (156), Expect = 2e-10, Method: Composition-based stats. Identities = 29/108 (26%), Positives = 45/108 (41%), Gaps = 10/108 (9%) Query: 40 GVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQ 99 V F+K P +L +I + G + R G+ G + V+ GS+ V Sbjct: 232 AVPLFQKLGPAVLVEIVRALRARTVPAGAVICRIGEPGDRMFFVVEGSVSVATPNPVE-- 289 Query: 100 DAVTICTLGIGTAFGE-SILDNTPRHATIVTRESSELLRIEQEDFKAL 146 LG G FGE +++ PR AT+ + LL + DF+ L Sbjct: 290 -------LGPGAFFGEMALISGEPRSATVSAATTVSLLSLHSADFQML 330 Score = 64.7 bits (156), Expect = 2e-10, Method: Composition-based stats. Identities = 25/111 (22%), Positives = 43/111 (38%), Gaps = 5/111 (4%) Query: 354 IKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVC 413 + L V E+ L + G V+ GE G + +++GSV+V Sbjct: 233 VPLFQKLGPAVLVEIVRALRART-VPAGAVICRIGEPGDRMFFVVEGSVSVATPNP---V 288 Query: 414 TLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANT 464 L G FG++AL++ PR+A++ L + DF + Sbjct: 289 ELGPGAFFGEMALISGEPRSATV-SAATTVSLLSLHSADFQMLCSSSPEIA 338 >4CYD-A nrPDB Length = 225 Score = 62.8 bits (151), Expect = 7e-10, Method: Composition-based stats. Identities = 21/93 (22%), Positives = 37/93 (39%), Gaps = 3/93 (3%) Query: 43 AFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAV 102 F+ P + + +G T+F +G+ G Y + +G VK++ + Sbjct: 11 IFQGVDPTAVNNLIQDMETVRFPRGATIFDEGEPGDRLYIITSGK--VKLARHAPDGREN 68 Query: 103 TICTLGIGTAFGE-SILDNTPRHATIVTRESSE 134 + +G FGE SI D PR ++ V Sbjct: 69 LLTIMGPSDMFGELSIFDPGPRTSSAVCVTEVH 101 Score = 55.5 bits (132), Expect = 1e-07, Method: Composition-based stats. Identities = 23/113 (20%), Positives = 44/113 (38%), Gaps = 6/113 (5%) Query: 356 ALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYG----KGV 411 + T L + + G +F++GE G YII G V + + + + Sbjct: 11 IFQGVDPTAVNNLIQDMETVRFPR-GATIFDEGEPGDRLYIITSGKVKLARHAPDGRENL 69 Query: 412 VCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANT 464 + + D FG+L++ + PR +S V H ++ + + D A Sbjct: 70 LTIMGPSDMFGELSIFDPGPRTSSAVC-VTEVHAATMNSDMLRNWVADHPAIA 121 >4ORF-A nrPDB Length = 340 Score = 62.4 bits (150), Expect = 1e-09, Method: Composition-based stats. Identities = 31/116 (26%), Positives = 53/116 (45%), Gaps = 5/116 (4%) Query: 345 EIIYDELLHIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNV 404 E+ +L ++ + + LA L A+ G VL QG+ ++ +I G V V Sbjct: 13 EVRAADLAALEFFTGCRPSALEPLATQLRPLK-AEPGQVLIRQGDPALTFMLIESGRVQV 71 Query: 405 V---IYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRIL 457 G +V + G G++AL+ DAP+ A++V E D++ F+ IL Sbjct: 72 SHAVADGPPIVLDIEPGLIIGEIALLRDAPKTATVVAAEPVIG-WVGDRDAFDTIL 126 Score = 58.6 bits (140), Expect = 1e-08, Method: Composition-based stats. Identities = 24/121 (19%), Positives = 47/121 (38%), Gaps = 4/121 (3%) Query: 28 SEDVDIIFTRLKGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGS 87 +E ++ L ++ F P+ L + E G L RQGD + + +G Sbjct: 9 AELTEVRAADLAALEFFTGCRPSALEPLATQLRPLKAEPGQVLIRQGDPALTFMLIESGR 68 Query: 88 LDVKVSETSSHQDAVTICTLGIGTAFGE-SILDNTPRHATIVTRESSELLRIEQEDFKAL 146 + V + + + G GE ++L + P+ AT+V E +++ F + Sbjct: 69 VQV---SHAVADGPPIVLDIEPGLIIGEIALLRDAPKTATVVAAEPVIGWVGDRDAFDTI 125 Query: 147 W 147 Sbjct: 126 L 126 >5H3O-A nrPDB Length = 738 Score = 62.0 bits (149), Expect = 1e-09, Method: Composition-based stats. Identities = 31/130 (23%), Positives = 52/130 (40%), Gaps = 15/130 (11%) Query: 31 VDIIFTRLKGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDV 90 + + F L+ V+ F+ LL ++ L + G + ++GDIG Y V G L V Sbjct: 486 MQVHFETLRKVRIFQDCEAGLLAELVLKLQLQVFSPGDFICKKGDIGREMYIVKRGRLQV 545 Query: 91 KVSETSSHQDAVTICTLGIGTAFGESIL-------DNTPRHATIVTRESSELLRIEQEDF 143 TL G+ FGE + + R A + + ++L + + D Sbjct: 546 V-----DDDGKKVFVTLQEGSVFGELSILNIAGSKNGNRRTANVRSVGYTDLFVLSKTD- 599 Query: 144 KALWEKYRQY 153 LW R+Y Sbjct: 600 --LWNALREY 607 >3E97-A nrPDB Length = 231 Score = 58.9 bits (141), Expect = 1e-08, Method: Composition-based stats. Identities = 35/175 (20%), Positives = 63/175 (36%), Gaps = 6/175 (3%) Query: 36 TRLKGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSET 95 LK F+ + +R+ N + + Q G + V G V+VS Sbjct: 6 DDLKRSPLFQNVPEDAMREALKVVTERNFQPDELVVEQDAEGEALHLVTTGV--VRVSRV 63 Query: 96 SSHQDAVTICTLGIGTAFGE-SILDNTPRHATIVTRESSELLRIEQEDFKALWEKYRQYM 154 S + + GE ++L + R A++ L + +E F+ + ++ + + Sbjct: 64 SLGGRERVLGDIYAPGVVGETAVLAHQERSASVRALTPVRTLMLHREHFELILRRHPRVL 123 Query: 155 AGLLAPPYGVMETGSNNDRIPDKENTPLIEPHV--PLRPAHTITKVPSEKILRAG 207 L A T N++ I +NT HV L VP ++L G Sbjct: 124 WNL-AEMLARRVTFLNDELIAFGQNTEAALTHVFANLYRQRLAAGVPQPEVLPLG 177 Score = 45.5 bits (106), Expect = 1e-04, Method: Composition-based stats. Identities = 24/114 (21%), Positives = 47/114 (41%), Gaps = 6/114 (5%) Query: 349 DELLHIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYG 408 D+L ++ RE V+ E + + ++ Q EG + +++ G V V Sbjct: 6 DDLKRSPLFQNVPEDAMREALKVV-TERNFQPDELVVEQDAEGEALHLVTTGVVRVSRVS 64 Query: 409 ----KGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILR 458 + V+ ++ G+ A++ R+AS+ L + +E F ILR Sbjct: 65 LGGRERVLGDIYAPGVVGETAVLAHQERSASVRALTP-VRTLMLHREHFELILR 117 >3KCC-A nrPDB Length = 260 Score = 55.5 bits (132), Expect = 1e-07, Method: Composition-based stats. Identities = 32/142 (22%), Positives = 62/142 (43%), Gaps = 8/142 (5%) Query: 332 LRKPPGQRTVDDLEIIYDELLHIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEG 391 P T DD + + D + T++ L+ I + + L +QGE+ Sbjct: 30 HMDSPDLGTDDDDKAMADIGSMVLGKPQTDPTLEWFLSHCHIHK--YPSKSTLIHQGEKA 87 Query: 392 TSWYIILKGSVNVVIYGKG----VVCTLHEGDDFGKLALVND-APRAASIVLREDNCHFL 446 + Y I+KGSV V+I + ++ L++GD G+L L + R+A + + C Sbjct: 88 ETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAK-TACEVA 146 Query: 447 RVDKEDFNRILRDVEANTVRLK 468 + + F ++++ +RL Sbjct: 147 EISYKKFRQLIQVNPDILMRLS 168 Score = 47.0 bits (110), Expect = 4e-05, Method: Composition-based stats. Identities = 19/88 (21%), Positives = 35/88 (39%), Gaps = 4/88 (4%) Query: 63 NLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGESILDNT- 121 TL QG+ Y ++ GS+ V + + + + + L G GE L Sbjct: 73 KYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKE--MILSYLNQGDFIGELGLFEEG 130 Query: 122 -PRHATIVTRESSELLRIEQEDFKALWE 148 R A + + + E+ I + F+ L + Sbjct: 131 QERSAWVRAKTACEVAEISYKKFRQLIQ 158 >4AVC-A nrPDB Length = 333 Score = 55.1 bits (131), Expect = 1e-07, Method: Composition-based stats. Identities = 31/135 (22%), Positives = 51/135 (37%), Gaps = 16/135 (11%) Query: 38 LKGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSS 97 L G+ F+ L + G L RQG+ ++ + +GS +V + Sbjct: 15 LAGMDVFQGCPAEGLVSLAASVQPLRAAAGQVLLRQGEPAVSFLLISSGSAEV----SHV 70 Query: 98 HQDAVTICTLG-IGTAFGE-SILDNTPRHATIVTRESSELLRIEQEDF----------KA 145 D V I G GE ++L ++PR AT+ T E + F + Sbjct: 71 GDDGVAIIARALPGMIVGEIALLRDSPRSATVTTIEPLTGWTGGRGAFATMVHIPGVGER 130 Query: 146 LWEKYRQYMAGLLAP 160 L RQ +A ++P Sbjct: 131 LLRTARQRLAAFVSP 145 Score = 52.0 bits (123), Expect = 1e-06, Method: Composition-based stats. Identities = 26/96 (27%), Positives = 40/96 (41%), Gaps = 4/96 (4%) Query: 349 DELLHIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYG 408 ++L + LA + A G VL QGE S+ +I GS V G Sbjct: 13 EDLAGMDVFQGCPAEGLVSLAASVQPLR-AAAGQVLLRQGEPAVSFLLISSGSAEVSHVG 71 Query: 409 KGVVCTLH---EGDDFGKLALVNDAPRAASIVLRED 441 V + G G++AL+ D+PR+A++ E Sbjct: 72 DDGVAIIARALPGMIVGEIALLRDSPRSATVTTIEP 107 >3UKN-A nrPDB Length = 212 Score = 55.1 bits (131), Expect = 1e-07, Method: Composition-based stats. Identities = 29/129 (22%), Positives = 51/129 (39%), Gaps = 3/129 (2%) Query: 331 ILRKPPGQRTVDDLEIIYDELLHIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEE 390 +L+ P + D + ELL + S R L+ ++I S G L QG+ Sbjct: 57 LLKDFPDELRADIAMHLNKELLQLPLFESASRGCLRSLS-LIIKTSFCAPGEFLIRQGDA 115 Query: 391 GTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAP-RAASIVLREDNCHFLRVD 449 + Y + GS+ V+ V+ L +GD G +L + + + V C + Sbjct: 116 LQAIYFVCSGSMEVL-KDNTVLAILGKGDLIGSDSLTKEQVIKTNANVKALTYCDLQYIS 174 Query: 450 KEDFNRILR 458 + +LR Sbjct: 175 LKGLREVLR 183 Score = 52.8 bits (125), Expect = 8e-07, Method: Composition-based stats. Identities = 31/144 (21%), Positives = 50/144 (34%), Gaps = 10/144 (6%) Query: 19 LDKRPLERSSEDVDIIFTRLKGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGT 78 L P E ++ + L + FE LR + L G L RQGD Sbjct: 58 LKDFPDELRADIAMHLNKELLQLPLFESASRGCLRSLSLIIKTSFCAPGEFLIRQGDALQ 117 Query: 79 NWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGESILDNTP---RHATIVTRESSEL 135 Y V +GS++V +D + LG G G L +A + +L Sbjct: 118 AIYFVCSGSMEVL-------KDNTVLAILGKGDLIGSDSLTKEQVIKTNANVKALTYCDL 170 Query: 136 LRIEQEDFKALWEKYRQYMAGLLA 159 I + + + Y +Y ++ Sbjct: 171 QYISLKGLREVLRLYPEYAQKFVS 194 >4I0B-A nrPDB Length = 222 Score = 55.1 bits (131), Expect = 2e-07, Method: Composition-based stats. Identities = 24/97 (24%), Positives = 47/97 (48%), Gaps = 6/97 (6%) Query: 377 HAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKG----VVCTLHEGDDFGKLALVND-AP 431 + L +QGE+ + Y I+KGSV V+I + ++ L++GD G+L L + Sbjct: 35 KYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQE 94 Query: 432 RAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLK 468 R+A + + C + + F ++++ +RL Sbjct: 95 RSAWVRAK-TACEVAEISYKKFRQLIQVNPDILMRLS 130 Score = 47.4 bits (111), Expect = 4e-05, Method: Composition-based stats. Identities = 19/88 (21%), Positives = 35/88 (39%), Gaps = 4/88 (4%) Query: 63 NLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGESILDNT- 121 TL QG+ Y ++ GS+ V + + + + + L G GE L Sbjct: 35 KYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKE--MILSYLNQGDFIGELGLFEEG 92 Query: 122 -PRHATIVTRESSELLRIEQEDFKALWE 148 R A + + + E+ I + F+ L + Sbjct: 93 QERSAWVRAKTACEVAEISYKKFRQLIQ 120 >3H3Z-A nrPDB Length = 235 Score = 53.2 bits (126), Expect = 5e-07, Method: Composition-based stats. Identities = 34/187 (18%), Positives = 69/187 (36%), Gaps = 9/187 (4%) Query: 39 KGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSH 98 + + + + + ++G TLF Q + + V+ G VK+ + Sbjct: 12 RNSLLIRSLPEQHVDALLSQAVWRSYDRGETLFLQEEKAQAIHVVIDGW--VKLFRMTPT 69 Query: 99 QDAVTICTLGIGTAFGESI-LDNTPRHATIVTRESSELLRIEQEDFKALWEKYRQYMAGL 157 + G +FGE++ L NTP + E++ I F +L + + + Sbjct: 70 GSEAVVSVFTRGESFGEAVALRNTPYPVSAEAVTPCEVMHIPSPVFVSLMRRDPEICISI 129 Query: 158 LAPPYG-----VMETGSNNDRIPDKENTPLIEPHVPLRPAHTITKVPSEKILRAGKI-LR 211 LA +G V + + + + +P +K+L AG++ ++ Sbjct: 130 LATTFGHLHSLVAQLEQLKAQTGAQRVAEFLLELCDCDTGACEVTLPYDKMLIAGRLGMK 189 Query: 212 IAILSRA 218 LSRA Sbjct: 190 PESLSRA 196 Score = 35.1 bits (79), Expect = 0.15, Method: Composition-based stats. Identities = 18/103 (17%), Positives = 40/103 (38%), Gaps = 8/103 (7%) Query: 363 TVKRELAGVLIFESH---AKGGTVLFNQGEEGTSWYIILKGSVNVVIY----GKGVVCTL 415 ++ + L+ ++ G LF Q E+ + ++++ G V + + VV Sbjct: 19 SLPEQHVDALLSQAVWRSYDRGETLFLQEEKAQAIHVVIDGWVKLFRMTPTGSEAVVSVF 78 Query: 416 HEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILR 458 G+ FG+ + + P S C + + F ++R Sbjct: 79 TRGESFGEAVALRNTPYPVSAEAVTP-CEVMHIPSPVFVSLMR 120 >2N7G-A nrPDB Length = 154 Score = 53.2 bits (126), Expect = 5e-07, Method: Composition-based stats. Identities = 29/116 (25%), Positives = 52/116 (44%), Gaps = 5/116 (4%) Query: 344 LEIIYDELLHIKALSHLSTTVKRELAGVLIFES-HAKGGTVLFNQGEEGTSWYIILKGSV 402 + + L H K + R LA + F++ HA G L + G+ T+ Y I +GS+ Sbjct: 20 FQSMRSLLQHCKPFRGATKGCLRALA--MKFKTTHAPPGDTLVHAGDLLTALYFISRGSI 77 Query: 403 NVVIYGKGVVCTLHEGDDFGKLALVNDAP-RAASIVLREDNCHFLRVDKEDFNRIL 457 ++ G VV L + D FG+ + P ++ V C ++ ++D +L Sbjct: 78 EIL-RGDVVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVL 132 Score = 48.2 bits (113), Expect = 2e-05, Method: Composition-based stats. Identities = 26/119 (21%), Positives = 48/119 (40%), Gaps = 10/119 (8%) Query: 38 LKGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSS 97 L+ K F LR + + + G TL GD+ T Y + GS+++ + Sbjct: 27 LQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGD--- 83 Query: 98 HQDAVTICTLGIGTAFGESI-LDNTPRHAT--IVTRESSELLRIEQEDFKALWEKYRQY 153 V + LG FGE + L P + + +L +I ++D + + Y ++ Sbjct: 84 ----VVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYPEF 138 >5VA1-A nrPDB Length = 795 Score = 52.8 bits (125), Expect = 8e-07, Method: Composition-based stats. Identities = 29/109 (26%), Positives = 50/109 (45%), Gaps = 5/109 (4%) Query: 351 LLHIKALSHLSTTVKRELAGVLIFES-HAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGK 409 L H K + R LA + F++ HA G L + G+ T+ Y I +GS+ ++ G Sbjct: 497 LQHCKPFRGATKGCLRALA--MKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEIL-RGD 553 Query: 410 GVVCTLHEGDDFGKLALVNDAP-RAASIVLREDNCHFLRVDKEDFNRIL 457 VV L + D FG+ + P ++ V C ++ ++D +L Sbjct: 554 VVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVL 602 Score = 48.2 bits (113), Expect = 2e-05, Method: Composition-based stats. Identities = 26/119 (21%), Positives = 48/119 (40%), Gaps = 10/119 (8%) Query: 38 LKGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSS 97 L+ K F LR + + + G TL GD+ T Y + GS+++ + Sbjct: 497 LQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGD--- 553 Query: 98 HQDAVTICTLGIGTAFGESI-LDNTPRHAT--IVTRESSELLRIEQEDFKALWEKYRQY 153 V + LG FGE + L P + + +L +I ++D + + Y ++ Sbjct: 554 ----VVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYPEF 608 >5K7L-A nrPDB Length = 857 Score = 50.1 bits (118), Expect = 5e-06, Method: Composition-based stats. Identities = 24/119 (20%), Positives = 44/119 (36%), Gaps = 10/119 (8%) Query: 38 LKGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSS 97 K AF LR + + + G ++ G+ + V++GSL+V Sbjct: 549 FKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVI------ 602 Query: 98 HQDAVTICTLGIGTAFGESILDNTPRH---ATIVTRESSELLRIEQEDFKALWEKYRQY 153 QD + LG G FG+ A + +L I+++ + + E Y + Sbjct: 603 -QDDEVVAILGKGDVFGDVFWKEATLAQSCANVRALTYCDLHVIKRDALQKVLEFYTAF 660 Score = 47.8 bits (112), Expect = 2e-05, Method: Composition-based stats. Identities = 29/141 (20%), Positives = 54/141 (38%), Gaps = 11/141 (7%) Query: 335 PPGQRTVDDLEIIYDELLHIKALSHLSTTVKRELAGVLIFES-HAKGGTVLFNQGEEGTS 393 P R + + A S R LA + F++ H G ++++ GE S Sbjct: 533 PKDMRADICVHLNRKVFKEHPAFRLASDGCLRALA--MEFQTVHCAPGDLIYHAGESVDS 590 Query: 394 WYIILKGSVNVVIYGKGVVCTLHEGDDFGKL----ALVNDAPRAASIVLREDNCHFLRVD 449 ++ GS+ V I VV L +GD FG + A + + A++ C + Sbjct: 591 LCFVVSGSLEV-IQDDEVVAILGKGDVFGDVFWKEATLAQS--CANVRA-LTYCDLHVIK 646 Query: 450 KEDFNRILRDVEANTVRLKEH 470 ++ ++L A + + Sbjct: 647 RDALQKVLEFYTAFSHSFSRN 667 >4F8A-A nrPDB Length = 160 Score = 50.1 bits (118), Expect = 5e-06, Method: Composition-based stats. Identities = 24/119 (20%), Positives = 44/119 (36%), Gaps = 10/119 (8%) Query: 38 LKGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSS 97 K AF LR + + + G ++ G+ + V++GSL+V Sbjct: 29 FKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVI------ 82 Query: 98 HQDAVTICTLGIGTAFGESILDNTPRH---ATIVTRESSELLRIEQEDFKALWEKYRQY 153 QD + LG G FG+ A + +L I+++ + + E Y + Sbjct: 83 -QDDEVVAILGKGDVFGDVFWKEATLAQSCANVRALTYCDLHVIKRDALQKVLEFYTAF 140 Score = 47.8 bits (112), Expect = 2e-05, Method: Composition-based stats. Identities = 29/141 (20%), Positives = 54/141 (38%), Gaps = 11/141 (7%) Query: 335 PPGQRTVDDLEIIYDELLHIKALSHLSTTVKRELAGVLIFES-HAKGGTVLFNQGEEGTS 393 P R + + A S R LA + F++ H G ++++ GE S Sbjct: 13 PKDMRADICVHLNRKVFKEHPAFRLASDGCLRALA--MEFQTVHCAPGDLIYHAGESVDS 70 Query: 394 WYIILKGSVNVVIYGKGVVCTLHEGDDFGKL----ALVNDAPRAASIVLREDNCHFLRVD 449 ++ GS+ V I VV L +GD FG + A + + A++ C + Sbjct: 71 LCFVVSGSLEV-IQDDEVVAILGKGDVFGDVFWKEATLAQS--CANVRA-LTYCDLHVIK 126 Query: 450 KEDFNRILRDVEANTVRLKEH 470 ++ ++L A + + Sbjct: 127 RDALQKVLEFYTAFSHSFSRN 147 >3DKW-A nrPDB Length = 227 Score = 47.8 bits (112), Expect = 2e-05, Method: Composition-based stats. Identities = 26/116 (22%), Positives = 49/116 (42%), Gaps = 4/116 (3%) Query: 38 LKGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSS 97 L+ FE P L+++ NL+KG +FRQG+ +Y +++G VK+ + Sbjct: 11 LQSHHLFEPLSPVQLQELLASSDLVNLDKGAYVFRQGEPAHAFYYLISGC--VKIYRLTP 68 Query: 98 HQDAVTICTLGIGTAFGESILD-NTPRH-ATIVTRESSELLRIEQEDFKALWEKYR 151 + F E+++ +TP + AT S+L R + + + Sbjct: 69 EGQEKILEVTNERNTFAEAMMFMDTPNYVATAQAVVPSQLFRFSNKAYLRQLQDNT 124 Score = 40.8 bits (94), Expect = 0.003, Method: Composition-based stats. Identities = 23/122 (18%), Positives = 47/122 (38%), Gaps = 6/122 (4%) Query: 343 DLEIIYDELL-HIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGS 401 + + ++ +LL LS +EL + K G +F QGE ++Y ++ G Sbjct: 2 EFQRVHQQLLQSHHLFEPLSPVQLQELLASSDLVNLDK-GAYVFRQGEPAHAFYYLISGC 60 Query: 402 VNVVIYG----KGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRIL 457 V + + ++ +E + F + + D P + R + + R L Sbjct: 61 VKIYRLTPEGQEKILEVTNERNTFAEAMMFMDTPNYVATAQAVVPSQLFRFSNKAYLRQL 120 Query: 458 RD 459 +D Sbjct: 121 QD 122 >2OZ6-A nrPDB Length = 207 Score = 47.8 bits (112), Expect = 3e-05, Method: Composition-based stats. Identities = 18/95 (18%), Positives = 39/95 (41%), Gaps = 9/95 (9%) Query: 378 AKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKG----VVCTLHEGDDFGKLALV----ND 429 + + G+ + + I+KGSV ++I ++ L+ GD FG+L L ++ Sbjct: 18 YTAKSTIIYAGDRCETLFFIIKGSVTILIEDDDGREMIIGYLNSGDFFGELGLFEKEGSE 77 Query: 430 APRAASIVLREDNCHFLRVDKEDFNRILRDVEANT 464 R+A + + + C + F + + Sbjct: 78 QERSAWVRAKVE-CEVAEISYAKFRELSQQDSEIL 111 Score = 42.0 bits (97), Expect = 0.001, Method: Composition-based stats. Identities = 19/108 (17%), Positives = 40/108 (37%), Gaps = 7/108 (6%) Query: 52 LRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGT 111 L ++ + T+ GD + ++ GS+ + + + + + I L G Sbjct: 6 LDKLLAHCHRRRYTAKSTIIYAGDRCETLFFIIKGSVTILIEDDDGRE--MIIGYLNSGD 63 Query: 112 AFGESIL-----DNTPRHATIVTRESSELLRIEQEDFKALWEKYRQYM 154 FGE L R A + + E+ I F+ L ++ + + Sbjct: 64 FFGELGLFEKEGSEQERSAWVRAKVECEVAEISYAKFRELSQQDSEIL 111 >5W5B-A nrPDB Length = 236 Score = 47.8 bits (112), Expect = 3e-05, Method: Composition-based stats. Identities = 21/95 (22%), Positives = 38/95 (40%), Gaps = 4/95 (4%) Query: 375 ESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKG---VVCTLHEGDDFGKLALVNDAP 431 G V+F+ + +I+ G + + + + VV LH GD G + L+ + P Sbjct: 51 VKEFAPGAVVFHADQTADGVWIVRHGLIELAVGSRRRRAVVNILHPGDVDGDIPLLLEMP 110 Query: 432 RAASIVLREDNCHFLRVDKEDFNRILRDVEANTVR 466 + L +D++ F R+L A R Sbjct: 111 MVYTGRA-LTQATCLFLDRQAFERLLATHPAIARR 144 >3T6A-A nrPDB Length = 333 Score = 47.4 bits (111), Expect = 3e-05, Method: Composition-based stats. Identities = 32/167 (19%), Positives = 61/167 (36%), Gaps = 20/167 (11%) Query: 742 ACPREQFDSLTPLPEQEGPTTGTV----GTFELMSSKDLAYQMTTYDWELFNCVHELELI 797 + +F+S PE + T + F K +A + + D + + E + Sbjct: 14 SFRPNEFESKFLPPENKPLETALLKRAKELFTNNDPKVIAQHVLSMDCRVARILGVSEEM 73 Query: 798 YHTFGR----------HNFKKTTANLDLFLRRFNEIQFWVVTEVCLCS-QLSKRVQLLKK 846 G H + + R N + + ++ C+ L R L K Sbjct: 74 RRNMGVSSGLELITLPHGHQLR----LDIIERHNTMAIGIAVDILGCTGTLEDRAATLSK 129 Query: 847 FIKIAAHCKE-YKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKF 892 I++A K+ +L SF A++ L ++RL TW L ++ + Sbjct: 130 IIQVAVELKDSMGDLYSFSALMKALEMPQITRLEKTWTALRHQYTQT 176 >3T6G-A nrPDB Length = 331 Score = 45.8 bits (107), Expect = 1e-04, Method: Composition-based stats. Identities = 27/126 (21%), Positives = 50/126 (39%), Gaps = 8/126 (6%) Query: 771 MSSKDLAYQMTTYDWELFNCV----HELELIYHTFGRHNFK--KTTANLDLFLRRFNEIQ 824 + ++ LA +T D + + L+ +G L RF+ + Sbjct: 48 VDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLLERFHTMS 107 Query: 825 FWVVTEVCLCS-QLSKRVQLLKKFIKIAAHCK-EYKNLNSFFAIVMGLSNVAVSRLALTW 882 + ++ + +R LL K I++AA + N+ SF A++ L +SRL TW Sbjct: 108 IMLAVDILGSTGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQISRLEQTW 167 Query: 883 EKLPSK 888 L + Sbjct: 168 VTLRQR 173 >4L11-A nrPDB Length = 204 Score = 44.7 bits (104), Expect = 2e-04, Method: Composition-based stats. Identities = 18/76 (23%), Positives = 37/76 (48%), Gaps = 2/76 (2%) Query: 376 SHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAP-RAA 434 +HA G +L ++G+ T Y I +GS+ ++ V+ L + D FG+ ++ ++ Sbjct: 98 THAPPGDILVHKGDVLTYLYFIARGSIEIL-KDDVVMAILGKDDIFGENPCIHSTLGKSN 156 Query: 435 SIVLREDNCHFLRVDK 450 S V C ++ + Sbjct: 157 SNVKALTYCDLHKIHR 172 >3B02-A nrPDB Length = 195 Score = 42.8 bits (99), Expect = 7e-04, Method: Composition-based stats. Identities = 25/97 (25%), Positives = 43/97 (44%), Gaps = 7/97 (7%) Query: 382 TVLFNQGEEGTSWYIILKGSVNVV-IYGKGVVCTLH---EGDDFGKLALVNDAPR---AA 434 ++ +GEE + Y + +G V VV + G + TL GD FG+ AL A R A Sbjct: 8 ETIYLRGEEARTLYRLEEGLVRVVELLPDGRLITLRHVLPGDYFGEEALEGKAYRYTAEA 67 Query: 435 SIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHD 471 +D E +R+ R++ R++ ++ Sbjct: 68 MTEAVVQGLEPRAMDHEALHRVARNLARQMRRVQAYE 104 Score = 34.7 bits (78), Expect = 0.21, Method: Composition-based stats. Identities = 14/78 (17%), Positives = 29/78 (37%), Gaps = 2/78 (2%) Query: 62 ENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGESILDNT 121 + + T++ +G+ Y + G + V E +T+ + G FGE L+ Sbjct: 2 KRFARKETIYLRGEEARTLYRLEEGLVRVV--ELLPDGRLITLRHVLPGDYFGEEALEGK 59 Query: 122 PRHATIVTRESSELLRIE 139 T + + +E Sbjct: 60 AYRYTAEAMTEAVVQGLE 77 >2GAU-A nrPDB Length = 232 Score = 41.2 bits (95), Expect = 0.002, Method: Composition-based stats. Identities = 21/101 (20%), Positives = 38/101 (37%), Gaps = 3/101 (2%) Query: 59 GYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFG-ESI 117 +K T+F +GDI N + + G +K+ + + G FG Sbjct: 33 IQPFPCKKASTVFSEGDIPNNLFYLYEGK--IKILREGVYGRFHISRIVKPGQFFGMRPY 90 Query: 118 LDNTPRHATIVTRESSELLRIEQEDFKALWEKYRQYMAGLL 158 +T + E+S++L I E +AL + + L Sbjct: 91 FAEETCSSTAIAVENSKVLAIPVEAIEALLKGNTSFCRYFL 131 >1ZYB-A nrPDB Length = 232 Score = 38.1 bits (87), Expect = 0.020, Method: Composition-based stats. Identities = 19/76 (25%), Positives = 31/76 (40%), Gaps = 3/76 (3%) Query: 344 LEIIYDELLHIKALSHLSTTVKRELAGV--LIFESHAKGGTVLFNQGEEGTSWYIILKGS 401 +E ++D LL + L + L F H K G + G T +LKG Sbjct: 13 METMFDTLLQLPLFQGLCHEDFTSILDKVKLHFIKH-KAGETIIKSGNPCTQLCFLLKGE 71 Query: 402 VNVVIYGKGVVCTLHE 417 +++V K + T+ E Sbjct: 72 ISIVTNAKENIYTVIE 87 Score = 37.8 bits (86), Expect = 0.025, Method: Composition-based stats. Identities = 16/116 (13%), Positives = 39/116 (33%), Gaps = 10/116 (8%) Query: 31 VDIIFTRLKGVKAFEKFHPNLLRQICLC--GYYENLEKGITLFRQGDIGTNWYAVLAGSL 88 ++ +F L + F+ I ++ + G T+ + G+ T +L G + Sbjct: 13 METMFDTLLQLPLFQGLCHEDFTSILDKVKLHFIKHKAGETIIKSGNPCTQLCFLLKGEI 72 Query: 89 DVKVSETSS----HQDAVTICTLGIGTAFGESILDNTPRHATIVTRESSELLRIEQ 140 + + + + + + FG NT ++ V + I + Sbjct: 73 SIVTNAKENIYTVIEQIEAPYLIEPQSLFG----MNTNYASSYVAHTEVHTVCISK 124 >1S94-A nrPDB Length = 180 Score = 36.2 bits (82), Expect = 0.073, Method: Composition-based stats. Identities = 23/80 (28%), Positives = 40/80 (50%), Gaps = 5/80 (6%) Query: 585 AAMYGDLLQEDDVAMAFLEEFYVSVSDDARMMAAFKEQLPELEKIVKQISEDAKAPQKKH 644 AA+ + E+DV EE V V M F EQ+ E+ ++ +IS++ A +KKH Sbjct: 12 AALKAAVSDEEDV-----EEVAVQVDSGGGFMEEFFEQVEEIRAMIDKISDNVDAVKKKH 66 Query: 645 KVLLQQFNTGDERAQKRQPI 664 +L T D+ ++ + + Sbjct: 67 SDILSAPQTDDQMKEELEEL 86 >3IWZ-A nrPDB Length = 230 Score = 36.2 bits (82), Expect = 0.075, Method: Composition-based stats. Identities = 21/81 (25%), Positives = 36/81 (44%), Gaps = 4/81 (4%) Query: 70 LFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGES--ILDNTPRHATI 127 +FR GD Y V++GS+ + E + + + G G GE +++ R + Sbjct: 45 VFRPGDPAGTLYYVISGSVSIIAEEDDDRE--LVLGYFGSGEFVGEMGLFIESDTREVIL 102 Query: 128 VTRESSELLRIEQEDFKALWE 148 TR EL I E + L++ Sbjct: 103 RTRTQCELAEISYERLQQLFQ 123 >1FSH-A nrPDB Length = 105 Score = 35.4 bits (80), Expect = 0.11, Method: Composition-based stats. Identities = 22/83 (26%), Positives = 37/83 (44%), Gaps = 1/83 (1%) Query: 209 ILRIAILSRAPHMIRDRKYHLKTYRQCCVGTELVDWMIQQTSCVHSRTQAVGMWQVLLED 268 I+R+ L + IRDR + T +G ++VDW+ R +A +L+ Sbjct: 24 IVRVMQLPDSGLEIRDRMWLKITIANAVIGADVVDWLYTHVEGFKERREARKYASSMLKH 83 Query: 269 GVLNHVDQERHFQDKYLFYRFLD 291 G L H + F ++ +Y F D Sbjct: 84 GFLRHTVNKITFSEQ-CYYVFGD 105 >3WCG-A nrPDB Length = 365 Score = 35.4 bits (80), Expect = 0.13, Method: Composition-based stats. Identities = 19/73 (26%), Positives = 30/73 (41%), Gaps = 3/73 (4%) Query: 284 YLFYRFLDDEREDAPLPTEEEKKEC---DEELQDTMLLLSQMGPDAHMRMILRKPPGQRT 340 YL R LD +D +P E + +E E L DT +S +G ++ R R Sbjct: 61 YLVLRALDTVEDDMSIPVEFKLRELPKFHEHLHDTTWCMSGVGVGRERELLERYTHVTRA 120 Query: 341 VDDLEIIYDELLH 353 L Y +++ Sbjct: 121 YSRLGKAYQDVIS 133 >2ZCW-A nrPDB Length = 202 Score = 34.7 bits (78), Expect = 0.21, Method: Composition-based stats. Identities = 23/109 (21%), Positives = 39/109 (35%), Gaps = 4/109 (3%) Query: 60 YYENLEKGITLFRQGDIG--TNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGESI 117 + + G + G G Y VL G V++ +A+T+ + G FGE Sbjct: 6 ETVSFKAGDVILYPGVPGPRDRAYRVLEGL--VRLEAVDEEGNALTLRLVRPGGFFGEEA 63 Query: 118 LDNTPRHATIVTRESSELLRIEQEDFKALWEKYRQYMAGLLAPPYGVME 166 L R L + + L + Q+++ LA Y +E Sbjct: 64 LFGQERIYFAEAATDVRLEPLPENPDPELLKDLAQHLSQGLAEAYRRIE 112 >5E44-A nrPDB Length = 259 Score = 34.3 bits (77), Expect = 0.27, Method: Composition-based stats. Identities = 22/118 (18%), Positives = 41/118 (34%), Gaps = 6/118 (5%) Query: 46 KFHPNLLRQICLCGYYEN-LEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTI 104 + + L Q+ + ++KG LF+ GD YA+ +G++ + Sbjct: 42 TLNDSELDQLDEIIERKKPIQKGQELFKAGDELKCLYAIRSGTIKSYTITEQGDEQITAF 101 Query: 105 CTLGIGTAFGESILDNTPRHATIVTRESSELLRIEQE---DFKALWEKYRQYMAGLLA 159 G G + + E+S + I E D K RQ + L++ Sbjct: 102 HL--AGDLVGFDAITEAQHPSFAQALETSMVCEIPYEILDDLSGKMPKLRQQIMRLMS 157 Score = 33.9 bits (76), Expect = 0.33, Method: Composition-based stats. Identities = 28/138 (20%), Positives = 52/138 (37%), Gaps = 10/138 (7%) Query: 360 LSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVN---VVIYGKGVVCTLH 416 L+ + +L ++ + + G LF G+E Y I G++ + G + H Sbjct: 43 LNDSELDQLDEIIERKKPIQKGQELFKAGDELKCLYAIRSGTIKSYTITEQGDEQITAFH 102 Query: 417 -EGDDFGKLALVNDA-PRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHD--- 471 GD G A+ P A + C +D + + + +RL ++ Sbjct: 103 LAGDLVGFDAITEAQHPSFAQALETSMVCEIPYEILDDLSGKMPKLRQQIMRLMSNEIKG 162 Query: 472 --QDVLVLEKVPAGNRAA 487 + +L+L K A R A Sbjct: 163 DQEMILLLSKKNAEERLA 180 >1V3F-A nrPDB Length = 120 Score = 33.9 bits (76), Expect = 0.35, Method: Composition-based stats. Identities = 21/64 (32%), Positives = 35/64 (54%), Gaps = 3/64 (4%) Query: 231 TYRQCCVGTELVDWMIQQTSCVHSRTQAVGMWQVLLEDGVLNHVDQERH--FQDKYLFYR 288 TY++ +G+ LVDW+I ++ SR +AV + +L+E+ L V + L + Sbjct: 33 TYKKTFLGSSLVDWLI-SSNFAASRLEAVTLASMLMEENFLRPVGVRSMGAIRSGDLAEQ 91 Query: 289 FLDD 292 FLDD Sbjct: 92 FLDD 95 >4CEX-C nrPDB Length = 570 Score = 31.2 bits (69), Expect = 2.2, Method: Composition-based stats. Identities = 22/96 (22%), Positives = 44/96 (45%), Gaps = 9/96 (9%) Query: 629 IVKQISEDAKAPQKKHKVLLQQFNTGDERAQKRQPI----RGSDEVLFKVYCIDHTYTTI 684 I+ +S DA A + +++L+ + T D+ ++R P+ GSD K Y + TI Sbjct: 356 IISMMSTDALAMGRAGEMVLRTWQTADKMKKQRGPLAEEKNGSDNFRLKRYVSKY---TI 412 Query: 685 RVPVAASVKEVISAVADKLGSGEGLIIVKMNSGGEK 720 +A + + ++ + G L++ + G K Sbjct: 413 NPAIAQGIAHEVGSIEE--GKFADLVLWEPKFFGVK 446 >5SUY-A nrPDB Length = 97 Score = 31.2 bits (69), Expect = 2.2, Method: Composition-based stats. Identities = 18/70 (25%), Positives = 33/70 (47%), Gaps = 1/70 (1%) Query: 222 IRDRKYHLKTYRQCCVGTELVDWMIQQTSCVHSRTQAVGMWQVLLEDGVLNHVDQERHFQ 281 +RDR + T +G+++VDW+ R +A LL+ G++ H + F Sbjct: 26 VRDRMWLKITIPNAFLGSDVVDWLYHHVEGFPERREARKYASGLLKAGLIRHTVNKITFS 85 Query: 282 DKYLFYRFLD 291 ++ +Y F D Sbjct: 86 EQ-CYYVFGD 94 >3ML6-A nrPDB Length = 385 Score = 31.2 bits (69), Expect = 2.2, Method: Composition-based stats. Identities = 18/70 (25%), Positives = 33/70 (47%), Gaps = 1/70 (1%) Query: 222 IRDRKYHLKTYRQCCVGTELVDWMIQQTSCVHSRTQAVGMWQVLLEDGVLNHVDQERHFQ 281 +RDR + T +G+++VDW+ R +A LL+ G++ H + F Sbjct: 25 VRDRMWLKITIPNAFLGSDVVDWLYHHVEGFPERREARKYASGLLKAGLIRHTVNKITFS 84 Query: 282 DKYLFYRFLD 291 ++ +Y F D Sbjct: 85 EQ-CYYVFGD 93 >1T9K-A nrPDB Length = 347 Score = 30.8 bits (68), Expect = 3.3, Method: Composition-based stats. Identities = 29/120 (24%), Positives = 50/120 (41%), Gaps = 14/120 (11%) Query: 165 METGSNNDRIPDKENTPLIEPHVPLRPAHTITKVPSEKILRAGKILRIAILSRAPHMIRD 224 ME N+ ++ D+ P IE +V + + E I+R + +A +RD Sbjct: 10 MEWSGNSLKLLDQRKLPFIEEYVECKTHEEVAHAIKEMIVRGAPAIGVAAAFGYVLGLRD 69 Query: 225 RKYHLKTYRQCCVGTELVDWMIQ-QTSCVHSRTQAVGMWQVL--LEDGVLNHVDQERHFQ 281 K G+ L DWM Q + + +R AV ++ L +E + D+E F+ Sbjct: 70 YK----------TGS-LTDWMKQVKETLARTRPTAVNLFWALNRMEKVFFENADRENLFE 118 >5V8F-D nrPDB Length = 529 Score = 30.4 bits (67), Expect = 3.5, Method: Composition-based stats. Identities = 25/98 (25%), Positives = 46/98 (46%), Gaps = 3/98 (3%) Query: 435 SIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLV-LEKVPAGNRAANQG-NS 492 SI+ +E + L ++ + L D E + ++ +Q + + L + A G + Sbjct: 89 SIIQKESHSVILVGPRQSYKTYLLDYELSLLQQSYKEQFITIRLNGFIHSEQTAINGIAT 148 Query: 493 QPQQKYTVMSGTPEKILEHFLETIRLEPSLNEATDSVL 530 Q +Q+ + G+ EKI + LETI SL E + +L Sbjct: 149 QLEQQLQKIHGSEEKIDDTSLETIS-SGSLTEVFEKIL 185 >3LOO-A nrPDB Length = 365 Score = 29.7 bits (65), Expect = 6.7, Method: Composition-based stats. Identities = 26/133 (19%), Positives = 45/133 (33%), Gaps = 9/133 (6%) Query: 12 SAEWIACLDKRPLERSSEDVDIIF-TRLKGVKAFEKFH--PNLLRQICLCGYYENLEKGI 68 SA ++ K LE VD++F + + ++F+ LR+I E G Sbjct: 213 SAPFVPQFYKNNLEEIFPYVDVLFGNETEAIALAKEFNYGTEDLREIGKRIAALPKENGK 272 Query: 69 ----TLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGESILDNTPRH 124 + QG + AG+ +V+ + T G G AF L + Sbjct: 273 RKRIVIITQGS--DPVLLIEAGTDNVREFPVQKLAPEQMVDTNGAGDAFVGGFLAQLLQS 330 Query: 125 ATIVTRESSELLR 137 T+ + Sbjct: 331 RTVDVCIKCGIWA 343 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.311 0.132 0.354 Lambda K H 0.267 0.0396 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 37,395,092 Number of Sequences: 36641 Number of extensions: 1531225 Number of successful extensions: 4796 Number of sequences better than 10.0: 76 Number of HSP's better than 10.0 without gapping: 89 Number of HSP's successfully gapped in prelim test: 44 Number of HSP's that attempted gapping in prelim test: 4295 Number of HSP's gapped (non-prelim): 273 length of query: 1011 length of database: 10,336,785 effective HSP length: 107 effective length of query: 904 effective length of database: 6,416,198 effective search space: 5800242992 effective search space used: 5800242992 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.3 bits) S2: 64 (29.3 bits)