BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q9BVC4 (326 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 5WBU-D nrPDB 683 0.0 6EMK-B nrPDB 303 5e-83 5FVM-C nrPDB 303 6e-83 5MZH-A nrPDB 82 5e-16 2H9P-A nrPDB 79 2e-15 5M25-A nrPDB 78 6e-15 5NNZ-B nrPDB 77 2e-14 6QX9-4B nrPDB 73 2e-13 6QX9-5O nrPDB 72 4e-13 6F3T-A nrPDB 70 1e-12 6MZM-G nrPDB 70 1e-12 5K1B-B nrPDB 66 2e-11 4V8M-A7 nrPDB 65 5e-11 5WYJ-BC nrPDB 65 6e-11 5OPT-p nrPDB 64 6e-11 5WYK-BB nrPDB 61 6e-10 6HQA-B nrPDB 60 9e-10 6Q8F-A nrPDB 60 1e-09 5UZ7-B nrPDB 58 5e-09 3JB9-L nrPDB 58 5e-09 5FL8-q nrPDB 57 2e-08 1NR0-A nrPDB 56 2e-08 4AEZ-A nrPDB 56 2e-08 6G51-g nrPDB 56 2e-08 6GMH-W nrPDB 55 3e-08 4V7E-Bg nrPDB 55 3e-08 2YNP-A nrPDB 55 6e-08 6EOJ-D nrPDB 54 7e-08 3MKQ-A nrPDB 53 2e-07 6N9G-C nrPDB 52 4e-07 4LG8-A nrPDB 52 5e-07 1VYH-C nrPDB 52 5e-07 6HHQ-h nrPDB 50 1e-06 5Z56-q nrPDB 50 2e-06 5I2T-A nrPDB 49 2e-06 5WLC-LO nrPDB 49 2e-06 5NZU-C nrPDB 49 2e-06 3DM0-A nrPDB 49 4e-06 6J6H-n nrPDB 49 4e-06 4V6W-Ag nrPDB 48 5e-06 5A9Q-0 nrPDB 48 6e-06 3JB9-g nrPDB 48 6e-06 5GAN-H nrPDB 47 8e-06 5A9Q-2 nrPDB 47 1e-05 5Y88-O nrPDB 47 1e-05 6ID0-T nrPDB 47 1e-05 5OQL-L nrPDB 47 2e-05 4A11-B nrPDB 46 2e-05 5N4A-A nrPDB 46 2e-05 3JAP-g nrPDB 45 4e-05 4BTS-AR nrPDB 45 5e-05 5OQL-J nrPDB 44 1e-04 5MWJ-A nrPDB 44 1e-04 5K19-A nrPDB 43 2e-04 5BJS-A nrPDB 42 3e-04 6CHG-D nrPDB 42 4e-04 5CXC-A nrPDB 42 4e-04 5XYI-g nrPDB 42 4e-04 4U1E-I nrPDB 41 6e-04 3ODT-A nrPDB 41 8e-04 6BX3-A nrPDB 41 9e-04 4E5Z-B nrPDB 40 0.002 2P9P-C nrPDB 39 0.002 2HES-X nrPDB 39 0.003 5K0Y-T nrPDB 39 0.003 3FM0-A nrPDB 39 0.003 4XFV-A nrPDB 39 0.004 4OWR-A nrPDB 39 0.004 5WLC-LS nrPDB 38 0.005 5WLC-LU nrPDB 37 0.009 4J0W-A nrPDB 37 0.015 5OQL-d nrPDB 36 0.018 6CHG-A nrPDB 36 0.021 6QDV-o nrPDB 36 0.021 5YZG-2 nrPDB 36 0.029 5YZG-W nrPDB 35 0.030 5LCW-Q nrPDB 35 0.044 4N14-A nrPDB 35 0.044 4GGA-A nrPDB 35 0.044 4G56-B nrPDB 35 0.050 5G04-R nrPDB 35 0.064 5WLC-LJ nrPDB 34 0.067 5CXB-B nrPDB 34 0.070 6BX3-B nrPDB 34 0.11 3C9C-A nrPDB 33 0.14 5Y1U-A nrPDB 33 0.21 5L9T-R nrPDB 33 0.25 4FHN-A nrPDB 32 0.30 4BH6-A nrPDB 32 0.30 5A31-R nrPDB 32 0.33 5WLC-LW nrPDB 32 0.40 3JRP-A nrPDB 32 0.46 6ELZ-p nrPDB 32 0.48 4BZK-B nrPDB 31 0.57 4L9O-A nrPDB 31 0.57 4XYI-A nrPDB 31 0.60 3JRO-A nrPDB 31 0.76 5XYH-A nrPDB 31 0.84 3EI3-B nrPDB 30 1.0 1PI6-A nrPDB 30 1.2 5WYJ-BE nrPDB 30 1.3 3ACP-A nrPDB 30 1.3 3BG0-A nrPDB 30 2.1 3CFV-B nrPDB 29 2.4 6C0F-s nrPDB 29 2.5 6CB1-s nrPDB 29 2.5 6EM1-m nrPDB 29 2.7 5WLC-SG nrPDB 29 3.0 5WJC-A nrPDB 29 3.1 3WJ9-A nrPDB 29 3.6 4J0X-A nrPDB 28 3.9 6E29-D nrPDB 28 5.2 6N8P-A nrPDB 28 6.3 >5WBU-D nrPDB Length = 328 Score = 683 bits (1763), Expect = 0.0, Method: Compositional matrix adjust. Identities = 326/326 (100%), Positives = 326/326 (100%) Query: 1 MNTSPGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAA 60 MNTSPGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAA Sbjct: 3 MNTSPGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAA 62 Query: 61 GYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQ 120 GYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQ Sbjct: 63 GYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQ 122 Query: 121 CQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDP 180 CQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDP Sbjct: 123 CQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDP 182 Query: 181 DASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSA 240 DASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSA Sbjct: 183 DASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSA 242 Query: 241 DQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVE 300 DQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVE Sbjct: 243 DQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVE 302 Query: 301 TGEIKREYGGHQKAVVCLAFNDSVLG 326 TGEIKREYGGHQKAVVCLAFNDSVLG Sbjct: 303 TGEIKREYGGHQKAVVCLAFNDSVLG 328 >6EMK-B nrPDB Length = 303 Score = 303 bits (777), Expect = 5e-83, Method: Compositional matrix adjust. Identities = 148/312 (47%), Positives = 202/312 (64%), Gaps = 14/312 (4%) Query: 13 VILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLNS 72 VIL +AGYDHT+RFW+A +G+C+RT+QH DSQVN LE+T D+ ++A AG+Q++R+YD+ + Sbjct: 3 VILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRT 62 Query: 73 NNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPIN 132 NPNP+ S++G N+ SV F +D RWM T ED T ++WD+RS ++ R ++ NAP+N Sbjct: 63 TNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSI--PRNYKHNAPVN 120 Query: 133 CVCLHPNQAELIVGDQSGAIHIWDLKTDH-NEQLIPEPEVSITSAHIDPDASYMAAVNST 191 V +HPNQ ELI D+ G I IWDL + QL PE + S+ S + D S +AA N+ Sbjct: 121 EVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTK 180 Query: 192 GNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRT-S 250 GNCYVW + + + L P TK AH+ Y + S D LATCSAD T ++W Sbjct: 181 GNCYVWEMPNHT--DASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDD 238 Query: 251 NFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGG 310 +F L T L + + W+W CAFS DS Y+VTASSD+ RLW + T EI R+YGG Sbjct: 239 DFKLETTL--------DGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGG 290 Query: 311 HQKAVVCLAFND 322 H K VC+A ND Sbjct: 291 HHKGAVCVALND 302 >5FVM-C nrPDB Length = 303 Score = 303 bits (777), Expect = 6e-83, Method: Compositional matrix adjust. Identities = 148/312 (47%), Positives = 201/312 (64%), Gaps = 14/312 (4%) Query: 13 VILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLNS 72 VILA+AGYDHT+RFW+A +G+C+RT+QH DSQVN LE+T D+ +AAAG+ H+R+YD+ S Sbjct: 3 VILASAGYDHTIRFWEALTGVCSRTIQHADSQVNRLEITSDKKYLAAAGHLHVRLYDIRS 62 Query: 73 NNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPIN 132 NNPNP+ S++G N+ S+ F ++ RWM + ED T ++WD+RS ++ QR ++ NAP+N Sbjct: 63 NNPNPVSSFEGHKGNVTSIAFQQENRWMVSSSEDGTIKVWDVRSPSV--QRNYKHNAPVN 120 Query: 133 CVCLHPNQAELIVGDQSGAIHIWDLKTDH-NEQLIPEPEVSITSAHIDPDASYMAAVNST 191 V +HPNQ ELI DQ G I IWDL + QL PE + S + D S + A N+ Sbjct: 121 EVAIHPNQGELISCDQDGNIRIWDLGENQCTNQLTPEDNTPLQSLSVASDGSMLVAGNNK 180 Query: 192 GNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTS- 250 GNCYVW + + + L P TK +HT+Y + S D LATCSAD T ++W Sbjct: 181 GNCYVWRMPHHT--DASTLEPVTKFKSHTKYITRVLLSADVKNLATCSADHTARVWNIED 238 Query: 251 NFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGG 310 N+ L T L + + W+W CAFS DS Y+VTA SD+ RLW + T EI R+YGG Sbjct: 239 NYQLETTL--------DGHQRWVWDCAFSADSAYLVTACSDHYVRLWDLSTSEIVRQYGG 290 Query: 311 HQKAVVCLAFND 322 H K VC+A ND Sbjct: 291 HHKGAVCVALND 302 >5MZH-A nrPDB Length = 452 Score = 81.6 bits (200), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 58/285 (20%), Positives = 123/285 (43%), Gaps = 22/285 (7%) Query: 15 LATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHI-RMYDLNSN 73 + T +D T + W A++G T++ +++ L P ++IA + +++D+ + Sbjct: 152 IVTGSFDKTCKLWDAYTGQLYYTLKGHQTEIVCLSFNPQSTIIATGSMDNTAKLWDVETG 211 Query: 74 NPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVN-APIN 132 ++ G I S+GF+ G + TG D +R+WD+R+ QC + + ++ Sbjct: 212 QERATLA--GHRAEIVSLGFNTGGDLIVTGSFDHDSRLWDVRTG--QCVHVLSGHRGEVS 267 Query: 133 CVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTG 192 + ++ G +WD+++ + + D + M + ++ G Sbjct: 268 STQFNYAGTLVVSGSIDCTSRLWDVRSGRCLSVKQGHTDEVLDVAFDAAGTKMVSASADG 327 Query: 193 NCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNF 252 + +++ G+ + H + F+P T L T S+D+TC++W Sbjct: 328 SARLYHTLTGVCQHT--------LVGHEGEISKVAFNPQGTRLITASSDKTCRLWDCDTG 379 Query: 253 SLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLW 297 L + G+ E ++ CAF+ + +I+T S DN R+W Sbjct: 380 EC---LQVLEGHTDE-----IFSCAFNYEGDFIITGSKDNTCRIW 416 Score = 71.6 bits (174), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 52/237 (21%), Positives = 103/237 (43%), Gaps = 14/237 (5%) Query: 14 ILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQH-IRMYDLNS 72 I+AT D+T + W +G T+ +++ +L +I + H R++D+ + Sbjct: 193 IIATGSMDNTAKLWDVETGQERATLAGHRAEIVSLGFNTGGDLIVTGSFDHDSRLWDVRT 252 Query: 73 NNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNA-PI 131 ++S G ++S F+ G + +G DCT+R+WD+RS +C + Q + + Sbjct: 253 GQCVHVLS--GHRGEVSSTQFNYAGTLVVSGSIDCTSRLWDVRSG--RCLSVKQGHTDEV 308 Query: 132 NCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNST 191 V +++ G+ ++ T + + E I+ +P + + +S Sbjct: 309 LDVAFDAAGTKMVSASADGSARLYHTLTGVCQHTLVGHEGEISKVAFNPQGTRLITASSD 368 Query: 192 GNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWR 248 C +W+ G E Q+ + HT C F+ + + T S D TC+IW+ Sbjct: 369 KTCRLWDCDTG---ECLQV-----LEGHTDEIFSCAFNYEGDFIITGSKDNTCRIWK 417 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 35/109 (32%), Positives = 49/109 (44%), Gaps = 13/109 (11%) Query: 216 IPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWG 275 + AH C F+ T S D+TCK+W T + L E + ++ Sbjct: 90 LRAHILPLTNCAFNKSGDRFITGSYDRTCKVWNTFTGEEVFTL--------EGHKNVVYA 141 Query: 276 CAFS---GDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFN 321 AF+ GD IVT S D +LW TG++ GHQ +VCL+FN Sbjct: 142 IAFNNPYGDK--IVTGSFDKTCKLWDAYTGQLYYTLKGHQTEIVCLSFN 188 Score = 52.0 bits (123), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 49/161 (30%), Positives = 67/161 (41%), Gaps = 29/161 (18%) Query: 172 SITSAHIDPDASYMAAVNSTGN----------CYVWNLTGGIGDEVTQLIPKTKIPAHTR 221 + AHI P + A N +G+ C VWN G+EV L H Sbjct: 88 KVLRAHILPLTN--CAFNKSGDRFITGSYDRTCKVWNTF--TGEEVFTL------EGHKN 137 Query: 222 YALQCRFS-PDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSG 280 F+ P + T S D+TCK+W L L G+ E + +F+ Sbjct: 138 VVYAIAFNNPYGDKIVTGSFDKTCKLWDAYTGQLYYTLK---GHQTE-----IVCLSFNP 189 Query: 281 DSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFN 321 S I T S DN A+LW VETG+ + GH+ +V L FN Sbjct: 190 QSTIIATGSMDNTAKLWDVETGQERATLAGHRAEIVSLGFN 230 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 47/238 (19%), Positives = 89/238 (37%), Gaps = 24/238 (10%) Query: 88 IASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCL----HPNQAEL 143 + + F++ G TG D T ++W+ + +F + N V +P ++ Sbjct: 97 LTNCAFNKSGDRFITGSYDRTCKVWN----TFTGEEVFTLEGHKNVVYAIAFNNPYGDKI 152 Query: 144 IVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGI 203 + G +WD T + + I +P ++ +A + +W++ G Sbjct: 153 VTGSFDKTCKLWDAYTGQLYYTLKGHQTEIVCLSFNPQSTIIATGSMDNTAKLWDVETG- 211 Query: 204 GDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSG 263 + + H + F+ L+ T S D ++W + L SG Sbjct: 212 -------QERATLAGHRAEIVSLGFNTGGDLIVTGSFDHDSRLWDVRTGQCVHVL---SG 261 Query: 264 NPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFN 321 + GE S F+ +V+ S D +RLW V +G GH V+ +AF+ Sbjct: 262 HRGEVS-----STQFNYAGTLVVSGSIDCTSRLWDVRSGRCLSVKQGHTDEVLDVAFD 314 Score = 34.3 bits (77), Expect = 0.068, Method: Compositional matrix adjust. Identities = 16/47 (34%), Positives = 23/47 (48%) Query: 276 CAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFND 322 CAF+ +T S D ++W TGE GH+ V +AFN+ Sbjct: 100 CAFNKSGDRFITGSYDRTCKVWNTFTGEEVFTLEGHKNVVYAIAFNN 146 >2H9P-A nrPDB Length = 329 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 66/289 (22%), Positives = 129/289 (44%), Gaps = 26/289 (8%) Query: 37 TVQHQDSQVNALEVTPDRSMIAAAGYQH-IRMYDLNSNNPNPIISYDGVNKNIASVGFHE 95 T+ V++++ +P+ +A++ I+++ IS G I+ V + Sbjct: 35 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTIS--GHKLGISDVAWSS 92 Query: 96 DGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAP-INCVCLHPNQAELIVGDQSGAIHI 154 D + + +D T +IWD+ S +C + + ++ + C +P ++ G ++ I Sbjct: 93 DSNLLVSASDDKTLKIWDVSSG--KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRI 150 Query: 155 WDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKT 214 WD+KT + +P +++ H + D S + + + G C +W+ G Q + KT Sbjct: 151 WDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASG------QCL-KT 203 Query: 215 KIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMW 274 I +FSP+ + + D T K+W ++S L +G+ E Sbjct: 204 LIDDDNPPVSFVKFSPNGKYILAATLDNTLKLW---DYSKGKCLKTYTGHKNEKY----- 255 Query: 275 GCAFSGDS----QYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLA 319 C F+ S ++IV+ S DNL +W ++T EI ++ GH V+ A Sbjct: 256 -CIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTA 303 Score = 71.6 bits (174), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 57/254 (22%), Positives = 107/254 (42%), Gaps = 18/254 (7%) Query: 75 PNPIISYD--GVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPIN 132 PN + + G K ++SV F +G W+ + D +IW + + I I+ Sbjct: 28 PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE-KTISGHKLGIS 86 Query: 133 CVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTG 192 V + L+ + IWD+ + + + + + +P ++ + + + Sbjct: 87 DVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDE 146 Query: 193 NCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNF 252 + +W++ G + +PAH+ F+ D +L+ + S D C+IW T++ Sbjct: 147 SVRIWDVKTGKCLKT--------LPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASG 198 Query: 253 SLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQ 312 + L I NP S FS + +YI+ A+ DN +LW G+ + Y GH+ Sbjct: 199 QCLKTL-IDDDNPPVSF------VKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHK 251 Query: 313 KAVVCLAFNDSVLG 326 C+ N SV G Sbjct: 252 NEKYCIFANFSVTG 265 Score = 69.3 bits (168), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 56/252 (22%), Positives = 107/252 (42%), Gaps = 28/252 (11%) Query: 10 SDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGY-QHIRMY 68 SD +L +A D T++ W SG C +T++ + V P ++I + + + +R++ Sbjct: 92 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 151 Query: 69 DLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVN 128 D+ + + + + +++V F+ DG + + D RIWD S I N Sbjct: 152 DVKTG--KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDN 209 Query: 129 APINCVCLHPNQAELIVGDQSGAIHIWD------LKT---DHNEQLIPEPEVSITSAHID 179 P++ V PN ++ + +WD LKT NE+ S+T Sbjct: 210 PPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGK-- 267 Query: 180 PDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCS 239 ++ + + Y+WNL E+ Q K+ HT + P ++A+ + Sbjct: 268 ----WIVSGSEDNLVYIWNLQ---TKEIVQ-----KLQGHTDVVISTACHPTENIIASAA 315 Query: 240 A--DQTCKIWRT 249 D+T K+W++ Sbjct: 316 LENDKTIKLWKS 327 >5M25-A nrPDB Length = 434 Score = 77.8 bits (190), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 58/237 (24%), Positives = 108/237 (45%), Gaps = 23/237 (9%) Query: 88 IASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAP-INCVCLHPNQAELIVG 146 I+ V + D + + +D T +IWD+ S +C + + ++ + C +P ++ G Sbjct: 190 ISDVAWSSDSNLLVSASDDKTLKIWDVSSG--KCLKTLKGHSNYVFCCNFNPQSNLIVSG 247 Query: 147 DQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDE 206 ++ IWD+KT + +P +++ H + D S + + + G C +W+ G Sbjct: 248 SFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASG---- 303 Query: 207 VTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPG 266 Q + KT I +FSP+ + + D T K+W ++S L +G+ Sbjct: 304 --QCL-KTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLW---DYSKGKCLKTYTGHKN 357 Query: 267 ESSRGWMWGCAFSGDS----QYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLA 319 E C F+ S ++IV+ S DNL +W ++T EI ++ GH V+ A Sbjct: 358 EKY------CIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTA 408 Score = 70.9 bits (172), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 57/255 (22%), Positives = 107/255 (41%), Gaps = 18/255 (7%) Query: 74 NPNPIISYD--GVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPI 131 PN + + G K ++SV F +G W+ + D +IW + + I I Sbjct: 132 KPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE-KTISGHKLGI 190 Query: 132 NCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNST 191 + V + L+ + IWD+ + + + + + +P ++ + + + Sbjct: 191 SDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFD 250 Query: 192 GNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSN 251 + +W++ G + +PAH+ F+ D +L+ + S D C+IW T++ Sbjct: 251 ESVRIWDVKTGKCLKT--------LPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTAS 302 Query: 252 FSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGH 311 + L I NP S FS + +YI+ A+ DN +LW G+ + Y GH Sbjct: 303 GQCLKTL-IDDDNPPVSF------VKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGH 355 Query: 312 QKAVVCLAFNDSVLG 326 + C+ N SV G Sbjct: 356 KNEKYCIFANFSVTG 370 Score = 68.6 bits (166), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 56/252 (22%), Positives = 107/252 (42%), Gaps = 28/252 (11%) Query: 10 SDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGY-QHIRMY 68 SD +L +A D T++ W SG C +T++ + V P ++I + + + +R++ Sbjct: 197 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 256 Query: 69 DLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVN 128 D+ + + + + +++V F+ DG + + D RIWD S I N Sbjct: 257 DVKTG--KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDN 314 Query: 129 APINCVCLHPNQAELIVGDQSGAIHIWD------LKT---DHNEQLIPEPEVSITSAHID 179 P++ V PN ++ + +WD LKT NE+ S+T Sbjct: 315 PPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTG---- 370 Query: 180 PDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCS 239 ++ + + Y+WNL E+ Q K+ HT + P ++A+ + Sbjct: 371 --GKWIVSGSEDNLVYIWNLQ---TKEIVQ-----KLQGHTDVVISTACHPTENIIASAA 420 Query: 240 A--DQTCKIWRT 249 D+T K+W++ Sbjct: 421 LENDKTIKLWKS 432 Score = 56.6 bits (135), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 40/128 (31%), Positives = 55/128 (42%), Gaps = 17/128 (13%) Query: 203 IGDEVTQLIP---------KTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFS 253 IG TQ P K + HT+ +FSP+ LA+ SAD+ KIW + Sbjct: 119 IGGSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGK 178 Query: 254 LMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQK 313 E +I G S W S DS +V+AS D ++W V +G+ + GH Sbjct: 179 F--EKTISGHKLGISDVAW------SSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSN 230 Query: 314 AVVCLAFN 321 V C FN Sbjct: 231 YVFCCNFN 238 >5NNZ-B nrPDB Length = 415 Score = 76.6 bits (187), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 70/307 (22%), Positives = 127/307 (41%), Gaps = 21/307 (6%) Query: 17 TAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVT-PDRSMIAAAGYQHI-RMYDLNSNN 74 T YD T + W SG T++ + V A+ P IA + +++ + + Sbjct: 109 TGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGK 168 Query: 75 PNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCV 134 ++ G I + F+ + TG D TA++WD+++ + + +A I + Sbjct: 169 CYH--TFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGE-EVYTLRGHSAEIISL 225 Query: 135 CLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNC 194 + + +I G + +WD T ++ I+SA + D S + + C Sbjct: 226 SFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTC 285 Query: 195 YVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSL 254 +W+ T G + H L F L+AT SAD T +I+ + Sbjct: 286 KLWDATNGK--------CVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKC 337 Query: 255 MTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKA 314 + +L G+ GE S+ +F+ +++T SSD AR+W +TG+ + GH Sbjct: 338 IAKLE---GHEGEISK-----ISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDE 389 Query: 315 VVCLAFN 321 + AFN Sbjct: 390 IFSCAFN 396 Score = 54.7 bits (130), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 53/283 (18%), Positives = 101/283 (35%), Gaps = 66/283 (23%) Query: 15 LATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHI-RMYDLNSN 73 +AT +D T + W +G C T + +++ L P +++A +++D+ Sbjct: 150 IATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQ-- 207 Query: 74 NPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDL---RSRNL---QCQRIFQV 127 N + + G + I S+ F+ G + TG D T +WD R N+ C I Sbjct: 208 NGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSA 267 Query: 128 NAPINCVCLHPNQAELIVGDQSGAIHIWDLK--------TDHNEQLIPE----------- 168 + +C + ++ G +WD T H+++++ Sbjct: 268 SFNWDC-------SLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIAT 320 Query: 169 -----------------------PEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGD 205 E I+ +P +++ +S +W+ G Sbjct: 321 ASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCL 380 Query: 206 EVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWR 248 +V + HT C F+ ++ T S D TC+IWR Sbjct: 381 QV--------LEGHTDEIFSCAFNYKGNIVITGSKDNTCRIWR 415 Score = 52.0 bits (123), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 34/109 (31%), Positives = 50/109 (45%), Gaps = 13/109 (11%) Query: 216 IPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWG 275 + AH + + T S D+TCK+W T++ + L E R ++ Sbjct: 88 LKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTL--------EGHRNVVYA 139 Query: 276 CAFS---GDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFN 321 AF+ GD I T S D +LW VETG+ + GH +VCL+FN Sbjct: 140 IAFNNPYGDK--IATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFN 186 Score = 47.8 bits (112), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 42/158 (26%), Positives = 72/158 (45%), Gaps = 21/158 (13%) Query: 173 ITSAHIDPDASYMAAVNSTGNCYV---WNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFS 229 + AHI P + A+N +G+C++ ++ T + D + T + H F+ Sbjct: 87 VLKAHILPLTN--VALNKSGSCFITGSYDRTCKLWDTASGEELNT-LEGHRNVVYAIAFN 143 Query: 230 -PDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGW---MWGCAFSGDSQYI 285 P +AT S D+TCK+W S+++G + RG + +F+ S + Sbjct: 144 NPYGDKIATGSFDKTCKLW-----------SVETGKCYHTFRGHTAEIVCLSFNPQSTLV 192 Query: 286 VTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDS 323 T S D A+LW ++ GE GH ++ L+FN S Sbjct: 193 ATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTS 230 Score = 47.8 bits (112), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 67/352 (19%), Positives = 129/352 (36%), Gaps = 73/352 (20%) Query: 27 WQAHSGICTRTVQHQD----SQVNAL--EVTPDRSMIAAAGYQHIRMY------DLNSNN 74 ++ H + T+++ D + V+AL E+ ++ A+ + +++ L N+ Sbjct: 19 YEKHGELKTKSIDLLDLGPSTDVSALVEEIQKAEPLLTASRTEQVKLLIQRLQEKLGQNS 78 Query: 75 PNPIISYDGVNKNI---ASVGFHEDGRWMYTGGEDCTARIWDLRS----------RNL-- 119 + + + +I +V ++ G TG D T ++WD S RN+ Sbjct: 79 NHTFYLFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVY 138 Query: 120 -----------------------------QCQRIFQVN-APINCVCLHPNQAELIVGDQS 149 +C F+ + A I C+ +P + G Sbjct: 139 AIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMD 198 Query: 150 GAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQ 209 +WD++ + I S + + + VW+ G +V Sbjct: 199 TTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWD--ADTGRKVNI 256 Query: 210 LIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESS 269 LI H F+ D +L+ T S D+TCK+W +N + L +G+ E Sbjct: 257 LI------GHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATL---TGHDDE-- 305 Query: 270 RGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFN 321 + F + I TAS+D AR++ T + + GH+ + ++FN Sbjct: 306 ---ILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFN 354 Score = 45.8 bits (107), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 33/147 (22%), Positives = 64/147 (43%), Gaps = 6/147 (4%) Query: 11 DPVILATAGYDHTVRFWQAHSGICTRTVQ-HQDSQVNALEVTPDRSMIAAAGYQHIRMYD 69 D ++ T D T + W A +G C T+ H D +++ + + A+ R++ Sbjct: 272 DCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIF- 330 Query: 70 LNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNA 129 ++ I +G I+ + F+ G + TG D TARIWD ++ QC ++ + + Sbjct: 331 -SAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTG--QCLQVLEGHT 387 Query: 130 PINCVCLHPNQAELIV-GDQSGAIHIW 155 C + +++ G + IW Sbjct: 388 DEIFSCAFNYKGNIVITGSKDNTCRIW 414 >6QX9-4B nrPDB Length = 522 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 69/299 (23%), Positives = 117/299 (39%), Gaps = 33/299 (11%) Query: 14 ILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTP---------DRSMIAAAGYQH 64 +LATA + + W T++ ++ V A+ P D ++ + A Sbjct: 245 MLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGS 304 Query: 65 IRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRI 124 ++++ L+S+ P + +G +A V +H GR++ T D + R+WDL + Q + + Sbjct: 305 VKLWSLDSDEP--VADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEA---QEEIL 359 Query: 125 FQVNAPINC--VCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDA 182 Q + + H + + G +WDL+T + I + P+ Sbjct: 360 HQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNG 419 Query: 183 SYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSP-DSTLLATCSAD 241 ++A + C VW+L Q IPAH +F P L T + D Sbjct: 420 YHIATGSGDNTCKVWDLR--------QRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYD 471 Query: 242 QTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVE 300 T KIW +S + L+ G + G S D Q I T S D +LW E Sbjct: 472 NTAKIWTHPGWSPLKTLAGHEGK--------VMGLDISSDGQLIATCSYDRTFKLWMAE 522 Score = 72.4 bits (176), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 59/246 (23%), Positives = 97/246 (39%), Gaps = 17/246 (6%) Query: 7 TVGSDP--VILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQH 64 TV DP V LA+ D +V+ W S ++ +V + P + Y Sbjct: 286 TVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDR 345 Query: 65 I-RMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQR 123 R++DL + I+ +G + + + FH+DG TGG D R+WDLR+ +C Sbjct: 346 SWRLWDLEAQEE--ILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTG--RCIM 401 Query: 124 IFQVN-APINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDP-D 181 + + I + PN + G +WDL+ IP + +T +P Sbjct: 402 FLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIH 461 Query: 182 ASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSAD 241 +++ +W G P + H + S D L+ATCS D Sbjct: 462 GNFLLTGAYDNTAKIWTHPG--------WSPLKTLAGHEGKVMGLDISSDGQLIATCSYD 513 Query: 242 QTCKIW 247 +T K+W Sbjct: 514 RTFKLW 519 Score = 44.3 bits (103), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 51/219 (23%), Positives = 86/219 (39%), Gaps = 31/219 (14%) Query: 114 LRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLK--------TDHNEQ- 164 LRS N C +I + PI+ PN L SG +W + HN Sbjct: 218 LRSLNNFCSQIGD-DRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNV 276 Query: 165 --LIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRY 222 ++ P+ +++ +DP +A+ + G+ +W+L DE P I HT Sbjct: 277 GAIVFHPKSTVS---LDPKDVNLASCAADGSVKLWSLDS---DE-----PVADIEGHTVR 325 Query: 223 ALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDS 282 + + P L T D++ ++W + E+ + G+ S G ++ AF D Sbjct: 326 VARVMWHPSGRFLGTTCYDRSWRLW---DLEAQEEILHQEGH----SMG-VYDIAFHQDG 377 Query: 283 QYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFN 321 T D R+W + TG GH K + + F+ Sbjct: 378 SLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFS 416 Score = 41.2 bits (95), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 45/210 (21%), Positives = 72/210 (34%), Gaps = 22/210 (10%) Query: 114 LRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSI 173 LR N I V P + V L P L G++ +W L +D I V + Sbjct: 269 LRGHNTNVGAI--VFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRV 326 Query: 174 TSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDST 233 P ++ + +W+L E + I + H+ F D + Sbjct: 327 ARVMWHPSGRFLGTTCYDRSWRLWDL------EAQEEILHQE--GHSMGVYDIAFHQDGS 378 Query: 234 LLATCSADQTCKIW--RTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSD 291 L T D ++W RT + E +K ++G FS + +I T S D Sbjct: 379 LAGTGGLDAFGRVWDLRTGRCIMFLEGHLKE----------IYGINFSPNGYHIATGSGD 428 Query: 292 NLARLWCVETGEIKREYGGHQKAVVCLAFN 321 N ++W + HQ V + F Sbjct: 429 NTCKVWDLRQRRCVYTIPAHQNLVTGVKFE 458 Score = 34.7 bits (78), Expect = 0.054, Method: Compositional matrix adjust. Identities = 23/98 (23%), Positives = 43/98 (43%) Query: 226 CRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYI 285 C FSP+S +LAT CK+W + +L+ L + N G + + Sbjct: 237 CHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNL 296 Query: 286 VTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDS 323 + ++D +LW +++ E + GH V + ++ S Sbjct: 297 ASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPS 334 >6QX9-5O nrPDB Length = 357 Score = 71.6 bits (174), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 71/295 (24%), Positives = 128/295 (43%), Gaps = 22/295 (7%) Query: 15 LATAGYDHTVRFWQAHSGICTR--TVQHQDSQVNALEVTPDRSMIAAAGY-QHIRMYDLN 71 LA+AG+D + W + G C T++ V L D SM+ +A + + ++D Sbjct: 81 LASAGFDRLILLWNVY-GDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWD-- 137 Query: 72 SNNPNPIISYDGVNKNIASVGFHEDG-RWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAP 130 S + G + S G + + TG +D T ++WD+R + + FQ Sbjct: 138 SETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKK--AAIQTFQNTYQ 195 Query: 131 INCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNS 190 + V + ++I G I +WDL+ + + S+T + + SY+ + Sbjct: 196 VLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAM 255 Query: 191 TGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTS 250 VW++ E I + + + L+C +SPD + +A SAD+ +W T+ Sbjct: 256 DNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTT 315 Query: 251 NFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIK 305 + ++ +L +G+ E AF D I++ASSD RL+ GEI+ Sbjct: 316 SRRILYKLPGHAGSINE--------VAFHPDEPIIISASSDK--RLY---MGEIQ 357 Score = 50.8 bits (120), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 42/194 (21%), Positives = 80/194 (41%), Gaps = 13/194 (6%) Query: 12 PVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQH-IRMYDL 70 P ++ T D TV+ W +T Q+ QV A+ I + G + I+++DL Sbjct: 164 PQLVCTGSDDGTVKLWDIRKKAAIQTFQNT-YQVLAVTFNDTSDQIISGGIDNDIKVWDL 222 Query: 71 NSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLR--SRNLQCQRIFQVN 128 N + G ++ + +G ++ + D T R+WD+R + +C +IFQ N Sbjct: 223 RQNKLT--YTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGN 280 Query: 129 AP------INCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDA 182 + C P+ +++ G +++WD + +P SI PD Sbjct: 281 VHNFEKNLLRC-SWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDE 339 Query: 183 SYMAAVNSTGNCYV 196 + + +S Y+ Sbjct: 340 PIIISASSDKRLYM 353 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 52/287 (18%), Positives = 112/287 (39%), Gaps = 21/287 (7%) Query: 41 QDSQVNALEVTPDRSMIAAAGYQH-IRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRW 99 + +V + P+ S +A+AG+ I ++++ + N + G + + + ++ DG Sbjct: 65 HEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDN-YATLKGHSGAVMELHYNTDGSM 123 Query: 100 MYTGGEDCTARIWD----LRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIW 155 +++ D T +WD R + L+ F VN+ C + G G + +W Sbjct: 124 LFSASTDKTVAVWDSETGERVKRLKGHTSF-VNS---CYPARRGPQLVCTGSDDGTVKLW 179 Query: 156 DLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTK 215 D++ Q + + + + + + + + VW+L Q Sbjct: 180 DIRKKAAIQTF-QNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLR--------QNKLTYT 230 Query: 216 IPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTE-LSIKSGNPGESSRGWMW 274 + H S + + L + + D T ++W F+ + I GN + + Sbjct: 231 MRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLR 290 Query: 275 GCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFN 321 C++S D I S+D +W + I + GH ++ +AF+ Sbjct: 291 -CSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFH 336 Score = 33.9 bits (76), Expect = 0.100, Method: Compositional matrix adjust. Identities = 23/108 (21%), Positives = 42/108 (38%), Gaps = 15/108 (13%) Query: 212 PKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRT----SNFSLMTELSIKSGNPGE 267 P + H C+F P+ + LA+ D+ +W N++ + + Sbjct: 58 PIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATL-----------K 106 Query: 268 SSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAV 315 G + ++ D + +AS+D +W ETGE + GH V Sbjct: 107 GHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFV 154 >6F3T-A nrPDB Length = 608 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 50/205 (24%), Positives = 94/205 (45%), Gaps = 14/205 (6%) Query: 45 VNALEVTPDRS-MIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTG 103 V +PDR+ +++++ +R++ L + ++ Y G N + F G + +G Sbjct: 354 VYGASFSPDRNYLLSSSEDGTVRLWSLQTFTC--LVGYKGHNYPVWDTQFSPYGYYFVSG 411 Query: 104 GEDCTARIWDLRSRNLQCQRIFQVN-APINCVCLHPNQAELIVGDQSGAIHIWDLKTDHN 162 G D AR+W + + Q RIF + A +NC HPN + G + +WD+ + Sbjct: 412 GHDRVARLW--ATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNC 469 Query: 163 EQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRY 222 ++ + I S P+ ++A + G +W++ G+ ++ + K HT Sbjct: 470 VRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGL------MVGELK--GHTDT 521 Query: 223 ALQCRFSPDSTLLATCSADQTCKIW 247 RFS D +LA+ S D T ++W Sbjct: 522 VCSLRFSRDGEILASGSMDNTVRLW 546 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 65/306 (21%), Positives = 117/306 (38%), Gaps = 63/306 (20%) Query: 33 ICTRTVQHQDSQVNALEVTPDRSMIAAA-GYQHIRMYDLNSNNPNPIISYDGVNKNIASV 91 IC T + + A++VT D S+IA +R++ + K + SV Sbjct: 269 ICFYTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSVTP-------------KKLRSV 315 Query: 92 GFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGA 151 D + +D RI D ++ + + + ++ + P+ P++ L+ + G Sbjct: 316 KQASDLSLIDKESDDVLERIMDEKTAS-ELKILYGHSGPVYGASFSPDRNYLLSSSEDGT 374 Query: 152 IHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCY-VWN---------LTG 201 + +W L+T + V G+ Y VW+ Sbjct: 375 VRLWSLQT------------------------FTCLVGYKGHNYPVWDTQFSPYGYYFVS 410 Query: 202 GIGDEVTQL------IPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLM 255 G D V +L P H RF P+S +AT SAD+T ++W N + + Sbjct: 411 GGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCV 470 Query: 256 TELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAV 315 I +G+ +G + FS + +++ T ++D LW + G + E GH V Sbjct: 471 ---RIFTGH-----KGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTV 522 Query: 316 VCLAFN 321 L F+ Sbjct: 523 CSLRFS 528 Score = 43.5 bits (101), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 34/135 (25%), Positives = 56/135 (41%), Gaps = 8/135 (5%) Query: 15 LATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPD-RSMIAAAGYQHIRMYDLNSN 73 +AT D TVR W +G C R +++L +P+ R + A + ++D+ Sbjct: 450 VATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHG 509 Query: 74 NPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRS--RNLQCQRIFQVNAPI 131 + G + S+ F DG + +G D T R+WD +L+ I Sbjct: 510 --LMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLETDDFTTATGHI 567 Query: 132 NCVCLHPNQAELIVG 146 N L N EL++G Sbjct: 568 N---LPENSQELLLG 579 >6MZM-G nrPDB Length = 800 Score = 69.7 bits (169), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 50/205 (24%), Positives = 94/205 (45%), Gaps = 14/205 (6%) Query: 45 VNALEVTPDRS-MIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTG 103 V +PDR+ +++++ +R++ L + ++ Y G N + F G + +G Sbjct: 546 VYGASFSPDRNYLLSSSEDGTVRLWSLQTFTC--LVGYKGHNYPVWDTQFSPYGYYFVSG 603 Query: 104 GEDCTARIWDLRSRNLQCQRIFQVN-APINCVCLHPNQAELIVGDQSGAIHIWDLKTDHN 162 G D AR+W + + Q RIF + A +NC HPN + G + +WD+ + Sbjct: 604 GHDRVARLW--ATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNC 661 Query: 163 EQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRY 222 ++ + I S P+ ++A + G +W++ G+ ++ + K HT Sbjct: 662 VRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGL------MVGELK--GHTDT 713 Query: 223 ALQCRFSPDSTLLATCSADQTCKIW 247 RFS D +LA+ S D T ++W Sbjct: 714 VCSLRFSRDGEILASGSMDNTVRLW 738 Score = 45.4 bits (106), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 46/214 (21%), Positives = 81/214 (37%), Gaps = 48/214 (22%) Query: 124 IFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDAS 183 ++ + P+ P++ L+ + G + +W L+T Sbjct: 539 LYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQT------------------------ 574 Query: 184 YMAAVNSTGNCY-VWN---------LTGGIGDEVTQL------IPKTKIPAHTRYALQCR 227 + V G+ Y VW+ G D V +L P H R Sbjct: 575 FTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTR 634 Query: 228 FSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVT 287 F P+S +AT SAD+T ++W N + + I +G+ +G + FS + +++ T Sbjct: 635 FHPNSNYVATGSADRTVRLWDVLNGNCV---RIFTGH-----KGPIHSLTFSPNGRFLAT 686 Query: 288 ASSDNLARLWCVETGEIKREYGGHQKAVVCLAFN 321 ++D LW + G + E GH V L F+ Sbjct: 687 GATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFS 720 Score = 43.9 bits (102), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 34/135 (25%), Positives = 56/135 (41%), Gaps = 8/135 (5%) Query: 15 LATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPD-RSMIAAAGYQHIRMYDLNSN 73 +AT D TVR W +G C R +++L +P+ R + A + ++D+ Sbjct: 642 VATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHG 701 Query: 74 NPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRS--RNLQCQRIFQVNAPI 131 + G + S+ F DG + +G D T R+WD +L+ I Sbjct: 702 --LMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLETDDFTTATGHI 759 Query: 132 NCVCLHPNQAELIVG 146 N L N EL++G Sbjct: 760 N---LPENSQELLLG 771 >5K1B-B nrPDB Length = 677 Score = 65.9 bits (159), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 41/154 (26%), Positives = 73/154 (47%), Gaps = 15/154 (9%) Query: 15 LATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGY-QHIRMYDLN-- 71 L +A D TV+ W AH G C T++ V AL D+ ++A+AG + I ++D+N Sbjct: 90 LISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTL 149 Query: 72 -----SNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQ 126 SNN S G +I S+ ++ G + +G + R+WD R+ C ++ + Sbjct: 150 TALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRT----CAKLMK 205 Query: 127 VNA---PINCVCLHPNQAELIVGDQSGAIHIWDL 157 + + + L+ + + + G G I +W L Sbjct: 206 LKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSL 239 Score = 28.9 bits (63), Expect = 2.9, Method: Compositional matrix adjust. Identities = 52/291 (17%), Positives = 98/291 (33%), Gaps = 72/291 (24%) Query: 45 VNALEVTPDRSMIAAAGYQHI-RMYDLNSNNPNPIISYDGVNKNIASVGFHED------- 96 VNAL++ P + + AG I R++ +N + +P I AS+ H D Sbjct: 33 VNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYI---------ASMEHHTDWVNDIVL 83 Query: 97 ---GRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIV-GDQSGAI 152 G+ + + D T ++W+ + C + + + EL+ I Sbjct: 84 CCNGKTLISASSDTTVKVWN--AHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQI 141 Query: 153 HIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIP 212 +WD+ T V+ +S + D+ Y A+N G Sbjct: 142 FLWDVNT-LTALTASNNTVTTSSLSGNKDSIYSLAMNQLG-------------------- 180 Query: 213 KTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGW 272 T++ + S ++ ++W + + +L + N Sbjct: 181 --------------------TIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDN-------- 212 Query: 273 MWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDS 323 + + D ++ SSD RLW + Y H + V L ND+ Sbjct: 213 VKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDA 263 >4V8M-A7 nrPDB Length = 318 Score = 64.7 bits (156), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 65/278 (23%), Positives = 129/278 (46%), Gaps = 30/278 (10%) Query: 32 GICTRTVQHQDSQVNALEVTPDRSMIAAAGYQH-IRMYDLNSNNPNPIISYDGVNKNIAS 90 G+ R ++ + V+ + ++ + + +A + H +R+++L N + G K++ S Sbjct: 57 GLPDRRLEGHSAFVSDVALSNNGNFAVSASWDHSLRLWNLQ--NGQCQYKFLGHTKDVLS 114 Query: 91 VGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAP---INCVCLHPN-QAELIV- 145 V F D R + +GG D R+W+++ +C A ++CV P+ A +IV Sbjct: 115 VAFSPDNRQIVSGGRDNALRVWNVKG---ECMHTLSRGAHTDWVSCVRFSPSLDAPVIVS 171 Query: 146 GDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGD 205 G + +WDL T + +TS + PD S A+ + G +W+LT G+ Sbjct: 172 GGWDNLVKVWDLATGRLVTDLKGHTNYVTSVTVSPDGSLCASSDKDGVARLWDLTK--GE 229 Query: 206 EVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSA-DQTCKIWRTSNFSLMTELSIKSGN 264 ++++ I Q FSP+ + C+A ++ +I+ N ++ EL+ + Sbjct: 230 ALSEMAAGAPIN-------QICFSPNRYWM--CAATEKGIRIFDLENKDIIVELAPEH-- 278 Query: 265 PGESSRGWMWGC---AFSGDSQYIVTASSDNLARLWCV 299 + S+ + C A+S D + + +DN+ R+W V Sbjct: 279 --QGSKKIVPECVSIAWSADGSTLYSGYTDNVIRVWGV 314 Score = 38.9 bits (89), Expect = 0.003, Method: Compositional matrix adjust. Identities = 29/110 (26%), Positives = 45/110 (40%), Gaps = 17/110 (15%) Query: 215 KIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRG--- 271 K HT+ L FSPD+ + + D ++W + T SRG Sbjct: 104 KFLGHTKDVLSVAFSPDNRQIVSGGRDNALRVWNVKGECMHTL-----------SRGAHT 152 Query: 272 -WMWGCAFSG--DSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCL 318 W+ FS D+ IV+ DNL ++W + TG + + GH V + Sbjct: 153 DWVSCVRFSPSLDAPVIVSGGWDNLVKVWDLATGRLVTDLKGHTNYVTSV 202 Score = 38.5 bits (88), Expect = 0.004, Method: Compositional matrix adjust. Identities = 34/159 (21%), Positives = 60/159 (37%), Gaps = 47/159 (29%) Query: 11 DPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDL 70 D ++ + G+D+ V+ W +G ++ + V ++ V+PD S+ A++ Sbjct: 165 DAPVIVSGGWDNLVKVWDLATGRLVTDLKGHTNYVTSVTVSPDGSLCASS---------- 214 Query: 71 NSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAP 130 +D AR+WDL + AP Sbjct: 215 ---------------------------------DKDGVARLWDLTKGEALSE--MAAGAP 239 Query: 131 INCVCLHPNQAELIVGDQSGAIHIWDLK-TDHNEQLIPE 168 IN +C PN+ + + G I I+DL+ D +L PE Sbjct: 240 INQICFSPNRYWMCAATEKG-IRIFDLENKDIIVELAPE 277 Score = 37.4 bits (85), Expect = 0.010, Method: Compositional matrix adjust. Identities = 29/103 (28%), Positives = 53/103 (51%), Gaps = 6/103 (5%) Query: 223 ALQCRFSPDS-TLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRG---WMWGCAF 278 +L C +P++ T + + S D+T W + +E S G P G ++ A Sbjct: 18 SLACPQTPETATKVVSTSRDKTLLSWGPNPDRHSSECSY--GLPDRRLEGHSAFVSDVAL 75 Query: 279 SGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFN 321 S + + V+AS D+ RLW ++ G+ + ++ GH K V+ +AF+ Sbjct: 76 SNNGNFAVSASWDHSLRLWNLQNGQCQYKFLGHTKDVLSVAFS 118 >5WYJ-BC nrPDB Length = 817 Score = 64.7 bits (156), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 66/275 (24%), Positives = 103/275 (37%), Gaps = 58/275 (21%) Query: 75 PNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQ-----RIFQVNA 129 P + Y+G + S+ EDG W+ T +D TA +W R C+ + +A Sbjct: 378 PLDVEIYEGHEDLLNSLDATEDGLWIATASKDNTAIVW--RYNENSCKFDIYAKYIGHSA 435 Query: 130 PINCVCLHPNQAE------LIVGDQSGAIHIWDLKTDHNEQLIPEP-------------- 169 + V L PN L+ I W +IP+P Sbjct: 436 AVTAVGL-PNIVSKGYPEFLLTASNDLTIKKW---------IIPKPTASMDVQIIKVSEY 485 Query: 170 -----EVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYAL 224 E I + + P+ S A + C +WNL G E+ + + H R Sbjct: 486 TRHAHEKDINALSVSPNDSIFATASYDKTCKIWNLENG---EL-----EATLANHKRGLW 537 Query: 225 QCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQY 284 F LLAT S D+T KIW FS+M L G+ R C+F + Sbjct: 538 DVSFCQYDKLLATSSGDKTVKIWSLDTFSVMKTLE---GHTNAVQR-----CSFINKQKQ 589 Query: 285 IVTASSDNLARLWCVETGEIKREYGGHQKAVVCLA 319 +++ +D L ++W +GE + GH + L+ Sbjct: 590 LISCGADGLIKIWDCSSGECLKTLDGHNNRLWALS 624 Score = 54.7 bits (130), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 69/326 (21%), Positives = 132/326 (40%), Gaps = 43/326 (13%) Query: 6 GTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVT-------PDRSMIA 58 G + S +LA+ + V+ W C T+Q S V L++ P ++++ Sbjct: 154 GQLNSKIWLLASGDTNGMVKVWDLVKRKCLHTLQEHTSAVRGLDIIEVPDNDEPSLNLLS 213 Query: 59 AAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDG---RWMYTGGEDCTARIWD-- 113 I ++D N ++ VN+ + S GF +DG R +YT G D ++ D Sbjct: 214 GGRDDIINLWDFNMKKKCKLLKTLPVNQQVESCGFLKDGDGKRIIYTAGGDAIFQLIDSE 273 Query: 114 ----LRSRNLQCQRIFQVNA-PINCVCLHPNQAELIVGDQS-GAIHI-WDLKTDHNEQLI 166 L+ N + +F + PI L +Q L++ DQ+ I++ DLK D Sbjct: 274 SGSVLKRTNKPIEELFIIGVLPI----LSNSQMFLVLSDQTLQLINVEEDLKND------ 323 Query: 167 PEPEVSITSA------------HIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKT 214 E + +TS+ ++ P+ + +A ++ + + + G E + + Sbjct: 324 -EDTIQVTSSIAGNHGIIADMRYVGPELNKLALATNSPSLRIIPVPDLSGPEASLPLDVE 382 Query: 215 KIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKS-GNPGESSRGWM 273 H + D +AT S D T +WR + S ++ K G+ + + Sbjct: 383 IYEGHEDLLNSLDATEDGLWIATASKDNTAIVWRYNENSCKFDIYAKYIGHSAAVTAVGL 442 Query: 274 WGCAFSGDSQYIVTASSDNLARLWCV 299 G ++++TAS+D + W + Sbjct: 443 PNIVSKGYPEFLLTASNDLTIKKWII 468 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 38/156 (24%), Positives = 65/156 (41%), Gaps = 14/156 (8%) Query: 12 PVILATAGYDHTVRFWQAHSGICTRTVQ----------HQDSQVNALEVTPDRSMIAAAG 61 P L TA D T++ W + VQ + +NAL V+P+ S+ A A Sbjct: 451 PEFLLTASNDLTIKKWIIPKPTASMDVQIIKVSEYTRHAHEKDINALSVSPNDSIFATAS 510 Query: 62 YQHI-RMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQ 120 Y ++++L + ++ + + V F + + + T D T +IW L + ++ Sbjct: 511 YDKTCKIWNLENGELEATLA--NHKRGLWDVSFCQYDKLLATSSGDKTVKIWSLDTFSVM 568 Query: 121 CQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWD 156 NA C ++ Q +LI G I IWD Sbjct: 569 KTLEGHTNAVQRCSFIN-KQKQLISCGADGLIKIWD 603 Score = 31.2 bits (69), Expect = 0.63, Method: Compositional matrix adjust. Identities = 23/111 (20%), Positives = 50/111 (45%), Gaps = 3/111 (2%) Query: 7 TVGSDPVILATAGYDHTVRFWQAHSGICTRTV-QHQDSQVNALEVTPDRSMIAAAGYQHI 65 +V + I ATA YD T + W +G T+ H+ + D+ + ++G + + Sbjct: 498 SVSPNDSIFATASYDKTCKIWNLENGELEATLANHKRGLWDVSFCQYDKLLATSSGDKTV 557 Query: 66 RMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRS 116 +++ L++ + + + +G + F + + + G D +IWD S Sbjct: 558 KIWSLDTF--SVMKTLEGHTNAVQRCSFINKQKQLISCGADGLIKIWDCSS 606 Score = 29.6 bits (65), Expect = 1.7, Method: Compositional matrix adjust. Identities = 14/46 (30%), Positives = 24/46 (52%) Query: 15 LATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAA 60 L + G D ++ W SG C +T+ ++++ AL D MI +A Sbjct: 590 LISCGADGLIKIWDCSSGECLKTLDGHNNRLWALSTMNDGDMIVSA 635 >5OPT-p nrPDB Length = 318 Score = 64.3 bits (155), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 61/272 (22%), Positives = 124/272 (45%), Gaps = 18/272 (6%) Query: 32 GICTRTVQHQDSQVNALEVTPDRSMIAAAGYQH-IRMYDLNSNNPNPIISYDGVNKNIAS 90 G R ++ + V+ + ++ + +A + H +R+++L + + G K++ S Sbjct: 57 GFPERRLEGHSAFVSDVALSNNGDFAVSASWDHSLRLWNLQTGVCQH--KFLGHTKDVLS 114 Query: 91 VGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPN-QAELIV-GDQ 148 V F D R + +GG D R+W+++ L ++CV P+ + LIV G Sbjct: 115 VTFSPDNRQIVSGGRDNALRVWNVKGECLHTLGRGAHTDWVSCVRFSPSLETPLIVSGGW 174 Query: 149 SGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVT 208 + +WD+ + + ITS + PD S A+ + G +W+LT G + ++ Sbjct: 175 DNLVKVWDIASGRLLTDLKGHTNYITSVTVSPDGSLCASSDKDGVARLWDLTKG--EALS 232 Query: 209 QLIPKTKIPAHTRYALQCRFSPDSTLLATCSA-DQTCKIWRTSNFSLMTELSIKSGNPGE 267 ++ I Q FSP+ + C+A ++ +I+ N ++ EL+ ++ + Sbjct: 233 EMAAGAPIN-------QICFSPNRYWM--CAATEKGIRIFDLENKDVIVELAPEAQQKSK 283 Query: 268 SSRGWMWGCAFSGDSQYIVTASSDNLARLWCV 299 + M A+S D + + +DN+ R+W V Sbjct: 284 KTPECM-SIAWSADGNTLYSGYTDNVIRVWSV 314 Score = 42.4 bits (98), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 45/240 (18%), Positives = 95/240 (39%), Gaps = 22/240 (9%) Query: 28 QAHSGICTRTV--QHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLNSNNPN---PIISYD 82 + H G T Q ++ + A+ + D ++IA D NS P + Sbjct: 10 KGHRGWVTALACPQITETYIKAVSTSRDNTLIAWGSNM-----DRNSEECEYGFPERRLE 64 Query: 83 GVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAE 142 G + ++ V +G + + D + R+W+L++ Q + + V P+ + Sbjct: 65 GHSAFVSDVALSNNGDFAVSASWDHSLRLWNLQTGVCQ-HKFLGHTKDVLSVTFSPDNRQ 123 Query: 143 LIVGDQSGAIHIWDLKTDHNEQLIPEPEVS-ITSAHIDPDASYMAAVNSTGN--CYVWNL 199 ++ G + A+ +W++K + L ++ P V+ + VW++ Sbjct: 124 IVSGGRDNALRVWNVKGECLHTLGRGAHTDWVSCVRFSPSLETPLIVSGGWDNLVKVWDI 183 Query: 200 TGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELS 259 G +L+ T + HT Y SPD +L A+ D ++W + ++E++ Sbjct: 184 ASG------RLL--TDLKGHTNYITSVTVSPDGSLCASSDKDGVARLWDLTKGEALSEMA 235 Score = 37.4 bits (85), Expect = 0.008, Method: Compositional matrix adjust. Identities = 33/158 (20%), Positives = 60/158 (37%), Gaps = 47/158 (29%) Query: 14 ILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLNSN 73 ++ + G+D+ V+ W SG ++ + + ++ V+PD S+ A++ Sbjct: 168 LIVSGGWDNLVKVWDIASGRLLTDLKGHTNYITSVTVSPDGSLCASS------------- 214 Query: 74 NPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINC 133 +D AR+WDL + APIN Sbjct: 215 ------------------------------DKDGVARLWDLTKGEALSE--MAAGAPINQ 242 Query: 134 VCLHPNQAELIVGDQSGAIHIWDLK-TDHNEQLIPEPE 170 +C PN+ + + G I I+DL+ D +L PE + Sbjct: 243 ICFSPNRYWMCAATEKG-IRIFDLENKDVIVELAPEAQ 279 Score = 37.4 bits (85), Expect = 0.009, Method: Compositional matrix adjust. Identities = 29/118 (24%), Positives = 50/118 (42%), Gaps = 17/118 (14%) Query: 196 VWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLM 255 +WNL G+ + K HT+ L FSPD+ + + D ++W L Sbjct: 93 LWNLQTGV--------CQHKFLGHTKDVLSVTFSPDNRQIVSGGRDNALRVWNVKGECLH 144 Query: 256 TELSIKSGNPGESSRGWMWGCAFSG--DSQYIVTASSDNLARLWCVETGEIKREYGGH 311 T + G + W+ FS ++ IV+ DNL ++W + +G + + GH Sbjct: 145 T---LGRG----AHTDWVSCVRFSPSLETPLIVSGGWDNLVKVWDIASGRLLTDLKGH 195 Score = 35.4 bits (80), Expect = 0.032, Method: Compositional matrix adjust. Identities = 16/45 (35%), Positives = 28/45 (62%) Query: 277 AFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFN 321 A S + + V+AS D+ RLW ++TG + ++ GH K V+ + F+ Sbjct: 74 ALSNNGDFAVSASWDHSLRLWNLQTGVCQHKFLGHTKDVLSVTFS 118 >5WYK-BB nrPDB Length = 943 Score = 61.2 bits (147), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 62/306 (20%), Positives = 118/306 (38%), Gaps = 36/306 (11%) Query: 8 VGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQ-HIR 66 + D +LATA + +++ W + C RT + + P ++ ++ Sbjct: 399 ISDDNKLLATAS-NGSLKIWNIKTHKCIRTFEC--GYALTCKFLPGGLLVILGTRNGELQ 455 Query: 67 MYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRN-------- 118 ++DL S++ I D + I S+ DG+ + TG D T + WD + N Sbjct: 456 LFDLASSSLLDTIE-DAHDAAIWSLDLTSDGKRLVTGSADKTVKFWDFKVENSLVPGTKN 514 Query: 119 -------LQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEV 171 L ++ I CV + P+ L + + ++ L + + ++ Sbjct: 515 KFLPVLKLHHDTTLELTDDILCVRVSPDDRYLAISLLDNTVKVFFLDSMKFYLSLYGHKL 574 Query: 172 SITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPD 231 + S I D+ + ++ N +W L GD L AH + +F P Sbjct: 575 PVLSIDISFDSKMIITSSADKNIKIWGL--DFGDCHKSLF------AHQDSIMNVKFLPQ 626 Query: 232 STLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSD 291 S +CS D K W F + +L + + +W A + D ++V++S D Sbjct: 627 SHNFFSCSKDAVVKYWDGEKFECIQKLY--------AHQSEVWALAVATDGGFVVSSSHD 678 Query: 292 NLARLW 297 + R+W Sbjct: 679 HSIRIW 684 Score = 57.8 bits (138), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 53/272 (19%), Positives = 111/272 (40%), Gaps = 25/272 (9%) Query: 62 YQHIRMYDLNSNNPNPI----ISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSR 117 Y I + +P P+ I G ++ S+ +D + + T + + +IW++++ Sbjct: 364 YYSIPYEKRDPTSPAPLKTHTIELQGQRTDVRSIDISDDNKLLATAS-NGSLKIWNIKTH 422 Query: 118 NLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEP-EVSITSA 176 +C R F+ + C L P +I+G ++G + ++DL + I + + +I S Sbjct: 423 --KCIRTFECGYALTCKFL-PGGLLVILGTRNGELQLFDLASSSLLDTIEDAHDAAIWSL 479 Query: 177 HIDPDASYMAAVNSTGNCYVWNLT---GGIGDEVTQLIPKTKIPAHTRYALQ-----CRF 228 + D + ++ W+ + + +P K+ T L R Sbjct: 480 DLTSDGKRLVTGSADKTVKFWDFKVENSLVPGTKNKFLPVLKLHHDTTLELTDDILCVRV 539 Query: 229 SPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTA 288 SPD LA D T K++ + L + + S DS+ I+T+ Sbjct: 540 SPDDRYLAISLLDNTVKVFFLDSMKFYLSLY--------GHKLPVLSIDISFDSKMIITS 591 Query: 289 SSDNLARLWCVETGEIKREYGGHQKAVVCLAF 320 S+D ++W ++ G+ + HQ +++ + F Sbjct: 592 SADKNIKIWGLDFGDCHKSLFAHQDSIMNVKF 623 Score = 34.3 bits (77), Expect = 0.073, Method: Compositional matrix adjust. Identities = 30/116 (25%), Positives = 54/116 (46%), Gaps = 11/116 (9%) Query: 48 LEVTPDRSMIAAAGYQH--IRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGE 105 LE D ++A GY I+++DL S +++++G I + F G + +G + Sbjct: 85 LEAHKDTDLLAV-GYADGVIKVWDLMSKTV--LLNFNGHKAAITLLQFDGTGTRLISGSK 141 Query: 106 DCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAE--LIVGDQSGAIHIWDLKT 159 D +WDL ++++ + + + Q E LI + G I +WDLKT Sbjct: 142 DSNIIVWDLVGE----VGLYKLRSHKDSITGFWCQGEDWLISTSKDGMIKLWDLKT 193 >6HQA-B nrPDB Length = 722 Score = 60.5 bits (145), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 50/214 (23%), Positives = 99/214 (46%), Gaps = 14/214 (6%) Query: 36 RTVQHQDSQVNALEVTPD-RSMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFH 94 R V H + V ++ +PD R +I+ + + +R++ L++ ++SY G + ++ V F Sbjct: 448 RLVGHSGA-VYGVDFSPDNRYLISCSEDKTVRLWSLDTYTC--LVSYKGHSSSVWDVKFS 504 Query: 95 EDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNA-PINCVCLHPNQAELIVGDQSGAIH 153 G + T D TAR+W ++ RIF + ++CV HPN L G Sbjct: 505 PMGHYFATASHDQTARLWSCD--HIYPLRIFAGHLNDVDCVEFHPNSTYLFTGSSDKTAR 562 Query: 154 IWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPK 213 +WD+ ++ +I + PD ++A+ +W+++ G + + + Sbjct: 563 MWDIARGECVRVFMGHSGAINCLAVSPDGRWLASAGEDSVVCLWDISTGRRIKAMRGHGR 622 Query: 214 TKIPAHTRYALQCRFSPDSTLLATCSADQTCKIW 247 + I Y+L FS + T+L + AD + ++W Sbjct: 623 SSI-----YSLA--FSREGTVLVSTGADNSVRVW 649 Score = 59.3 bits (142), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 58/247 (23%), Positives = 97/247 (39%), Gaps = 48/247 (19%) Query: 78 IISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLH 137 + ++ N ++ + F++D + +G +D ++W + L R N P N Sbjct: 383 MYTFHNTNNDLTCLKFNDDSTMVASGFQDSFIKLWSIDGSPL---RSLLKNDPYN---QQ 436 Query: 138 PNQAELIVGDQ-----SGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTG 192 N + G + SGA++ D PD Y+ + + Sbjct: 437 NNDGVAVKGSRRLVGHSGAVYGVDFS---------------------PDNRYLISCSEDK 475 Query: 193 NCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNF 252 +W+L D T L+ H+ +FSP AT S DQT ++W + Sbjct: 476 TVRLWSL-----DTYTCLV---SYKGHSSSVWDVKFSPMGHYFATASHDQTARLWSCDH- 526 Query: 253 SLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQ 312 + L I +G+ + F +S Y+ T SSD AR+W + GE R + GH Sbjct: 527 --IYPLRIFAGHLNDVD-----CVEFHPNSTYLFTGSSDKTARMWDIARGECVRVFMGHS 579 Query: 313 KAVVCLA 319 A+ CLA Sbjct: 580 GAINCLA 586 Score = 57.8 bits (138), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 47/208 (22%), Positives = 93/208 (44%), Gaps = 7/208 (3%) Query: 15 LATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGY-QHIRMYDLNSN 73 L + D TVR W + C + + S V ++ +P A A + Q R++ + + Sbjct: 468 LISCSEDKTVRLWSLDTYTCLVSYKGHSSSVWDVKFSPMGHYFATASHDQTARLW--SCD 525 Query: 74 NPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNA-PIN 132 + P+ + G ++ V FH + +++TG D TAR+WD+ +R +C R+F ++ IN Sbjct: 526 HIYPLRIFAGHLNDVDCVEFHPNSTYLFTGSSDKTARMWDI-ARG-ECVRVFMGHSGAIN 583 Query: 133 CVCLHPNQAELIVGDQSGAIHIWDLKTDHN-EQLIPEPEVSITSAHIDPDASYMAAVNST 191 C+ + P+ L + + +WD+ T + + SI S + + + + + Sbjct: 584 CLAVSPDGRWLASAGEDSVVCLWDISTGRRIKAMRGHGRSSIYSLAFSREGTVLVSTGAD 643 Query: 192 GNCYVWNLTGGIGDEVTQLIPKTKIPAH 219 + VW++ Q P + A Sbjct: 644 NSVRVWDVKKNTNSPSAQPEPINDVTAQ 671 Score = 55.1 bits (131), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 32/107 (29%), Positives = 48/107 (44%), Gaps = 8/107 (7%) Query: 215 KIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMW 274 ++ H+ FSPD+ L +CS D+T ++W ++ + G SS +W Sbjct: 448 RLVGHSGAVYGVDFSPDNRYLISCSEDKTVRLWSLDTYTCLVSYK------GHSSS--VW 499 Query: 275 GCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFN 321 FS Y TAS D ARLW + R + GH V C+ F+ Sbjct: 500 DVKFSPMGHYFATASHDQTARLWSCDHIYPLRIFAGHLNDVDCVEFH 546 Score = 45.8 bits (107), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 30/112 (26%), Positives = 51/112 (45%), Gaps = 14/112 (12%) Query: 224 LQC-RFSPDSTLLATCSADQTCKIWRTSNFSLMTEL-------------SIKSGNPGESS 269 L C +F+ DST++A+ D K+W L + L ++K Sbjct: 393 LTCLKFNDDSTMVASGFQDSFIKLWSIDGSPLRSLLKNDPYNQQNNDGVAVKGSRRLVGH 452 Query: 270 RGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFN 321 G ++G FS D++Y+++ S D RLW ++T Y GH +V + F+ Sbjct: 453 SGAVYGVDFSPDNRYLISCSEDKTVRLWSLDTYTCLVSYKGHSSSVWDVKFS 504 >6Q8F-A nrPDB Length = 514 Score = 60.1 bits (144), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 58/251 (23%), Positives = 108/251 (43%), Gaps = 26/251 (10%) Query: 11 DPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQ-VNALEVTPDRSMIAAAGY-QHIRMY 68 D +LAT D ++ W+ SG C R + S+ V L + D S I +A + Q IR++ Sbjct: 276 DTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIH 335 Query: 69 DLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQ-- 126 L S + + G + + F +DG ++ + D T +IW++++ +C F+ Sbjct: 336 GLKSG--KTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTT--ECSNTFKSL 391 Query: 127 -----VNAPINCVCLHPNQAE-LIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDP 180 + +N V L P E +V ++S + I +++ Q++ S +S + Sbjct: 392 GSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQG----QIVR----SFSSGKREG 443 Query: 181 DASYMAAVNSTGN---CYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLAT 237 A++ G C + VT + +T + H + + P L+AT Sbjct: 444 GDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERT-LTVHEKDVIGIAHHPHQNLIAT 502 Query: 238 CSADQTCKIWR 248 S D K+W+ Sbjct: 503 YSEDGLLKLWK 513 Score = 50.8 bits (120), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 45/191 (23%), Positives = 77/191 (40%), Gaps = 31/191 (16%) Query: 125 FQVNAPINCVCLHPNQAELIVGDQSGAIHIW---------DLKTDHNEQLIPEPEVSITS 175 F + + C P+ L+ G G I +W DLK + + + ++ Sbjct: 212 FGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDD-AVLC 270 Query: 176 AHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLL 235 D +A G VW + G Q + + + AH++ FS DS+ + Sbjct: 271 MCFSRDTEMLATGAQDGKIKVWKIQSG------QCLRRFE-RAHSKGVTCLSFSKDSSQI 323 Query: 236 ATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRG---WMWGCAFSGDSQYIVTASSDN 292 + S DQT +I +KSG + RG ++ F+ D YI++ASSD Sbjct: 324 LSASFDQTIRIH-----------GLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDG 372 Query: 293 LARLWCVETGE 303 ++W ++T E Sbjct: 373 TVKIWNMKTTE 383 Score = 49.3 bits (116), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 38/149 (25%), Positives = 66/149 (44%), Gaps = 19/149 (12%) Query: 173 ITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRY-----ALQCR 227 + A PD Y+ + G VWN T G ++ K A + A+ C Sbjct: 218 VECARFSPDGQYLVTGSVDGFIEVWNFTTG------KIRKDLKYQAQDNFMMMDDAVLCM 271 Query: 228 -FSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIV 286 FS D+ +LAT + D K+W+ + + ++ + G + +FS DS I+ Sbjct: 272 CFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFE-RAHSKGVTC------LSFSKDSSQIL 324 Query: 287 TASSDNLARLWCVETGEIKREYGGHQKAV 315 +AS D R+ +++G+ +E+ GH V Sbjct: 325 SASFDQTIRIHGLKSGKTLKEFRGHSSFV 353 Score = 48.5 bits (114), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 56/302 (18%), Positives = 109/302 (36%), Gaps = 46/302 (15%) Query: 41 QDSQVNALEVTPD-RSMIAAAGYQHIRMYDLNSNNPNPIISYDG------VNKNIASVGF 93 Q S V +PD + ++ + I +++ + + Y ++ + + F Sbjct: 214 QKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCF 273 Query: 94 HEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQV--NAPINCVCLHPNQAELIVGDQSGA 151 D + TG +D ++W ++S QC R F+ + + C+ + ++++ Sbjct: 274 SRDTEMLATGAQDGKIKVWKIQSG--QCLRRFERAHSKGVTCLSFSKDSSQILSASFDQT 331 Query: 152 IHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNL------------ 199 I I LK+ + + A D Y+ + +S G +WN+ Sbjct: 332 IRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSL 391 Query: 200 --TGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTE 257 T G V +I K P H C+ T I M Sbjct: 392 GSTAGTDITVNSVILLPKNPEH---------------FVVCNRSNTVVIMN------MQG 430 Query: 258 LSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVC 317 ++S + G+ G CA S ++I D + + TG+++R H+K V+ Sbjct: 431 QIVRSFSSGKREGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIG 490 Query: 318 LA 319 +A Sbjct: 491 IA 492 Score = 35.4 bits (80), Expect = 0.032, Method: Compositional matrix adjust. Identities = 23/72 (31%), Positives = 35/72 (48%), Gaps = 15/72 (20%) Query: 265 PGESSRGWMWG------CA-FSGDSQYIVTASSDNLARLWCVETGEIKRE--------YG 309 P + SR +G CA FS D QY+VT S D +W TG+I+++ + Sbjct: 203 PTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFM 262 Query: 310 GHQKAVVCLAFN 321 AV+C+ F+ Sbjct: 263 MMDDAVLCMCFS 274 >5UZ7-B nrPDB Length = 351 Score = 58.2 bits (139), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 42/178 (23%), Positives = 76/178 (42%), Gaps = 13/178 (7%) Query: 143 LIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGG 202 L+ Q G + IWD T + IP + + P +Y+A C ++NL Sbjct: 81 LVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTR 140 Query: 203 IGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKS 262 G+ + ++ HT Y CRF D+ ++ T S D TC +W T + + Sbjct: 141 EGN----VRVSRELAGHTGYLSCCRFLDDNQIV-TSSGDTTCALWDIETGQQTTTFTGHT 195 Query: 263 GNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAF 320 G+ + + + D++ V+ + D A+LW V G ++ + GH+ + + F Sbjct: 196 GD--------VMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICF 245 Score = 52.8 bits (125), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 26/108 (24%), Positives = 49/108 (45%), Gaps = 1/108 (0%) Query: 7 TVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHI- 65 ++ D + + D + + W G+C +T +S +NA+ P+ + A Sbjct: 202 SLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATC 261 Query: 66 RMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWD 113 R++DL ++ S+D + I SV F + GR + G +D +WD Sbjct: 262 RLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWD 309 Score = 44.7 bits (104), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 54/286 (18%), Positives = 95/286 (33%), Gaps = 57/286 (19%) Query: 9 GSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHI-RM 67 G+D +L +A D + W +++ + + S V P + +A G +I + Sbjct: 75 GTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSI 134 Query: 68 YDLNSN-----------------------NPNPIISYDGVNK------------------ 86 Y+L + + N I++ G Sbjct: 135 YNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGH 194 Query: 87 --NIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVN-APINCVCLHPNQAEL 143 ++ S+ D R +G D +A++WD+R C++ F + + IN +C PN Sbjct: 195 TGDVMSLSLAPDTRLFVSGACDASAKLWDVREG--MCRQTFTGHESDINAICFFPNGNAF 252 Query: 144 IVGDQSGAIHIWDLKTDHNEQLIPEPEV--SITSAHIDPDASYMAAVNSTGNCYVWNLTG 201 G ++DL+ D + ITS + A NC VW Sbjct: 253 ATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVW---- 308 Query: 202 GIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIW 247 + + + H + D +AT S D KIW Sbjct: 309 ----DALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIW 350 Score = 36.2 bits (82), Expect = 0.019, Method: Compositional matrix adjust. Identities = 48/289 (16%), Positives = 105/289 (36%), Gaps = 17/289 (5%) Query: 36 RTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHE 95 RT++ +++ A+ D ++ +A Q ++ +S N + + + + + + Sbjct: 60 RTLRGHLAKIYAMHWGTDSRLLVSAS-QDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAP 118 Query: 96 DGRWMYTGGEDCTARIWDLRSR--NLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIH 153 G ++ GG D I++L++R N++ R + C + +++ Sbjct: 119 SGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCA 178 Query: 154 IWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPK 213 +WD++T + S + PD + + +W++ G+ + Sbjct: 179 LWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGM--------CR 230 Query: 214 TKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWM 273 H F P+ AT S D TC++ F L + + + + G + Sbjct: 231 QTFTGHESDINAICFFPNGNAFATGSDDATCRL-----FDLRADQELMTYSHDNIICG-I 284 Query: 274 WGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFND 322 +FS + ++ D +W + GH V CL D Sbjct: 285 TSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTD 333 >3JB9-L nrPDB Length = 340 Score = 58.2 bits (139), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 33/143 (23%), Positives = 65/143 (45%), Gaps = 2/143 (1%) Query: 105 EDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQ 164 +DCT ++WD RS++ C + + P+ V + ++ +G GAI IWDL+ +H Sbjct: 156 DDCTMKVWDSRSKD--CIKTIEEKYPLTAVAIAQQGTQVFIGGIDGAIKIWDLRNNHCSH 213 Query: 165 LIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYAL 224 ++ + ITS I D S + + + ++++ + I + I L Sbjct: 214 VLKGHKDIITSLAISKDGSSLLSNSMDNTVRIFDVKPFASAQRQLQIFEGAIHGQEHNLL 273 Query: 225 QCRFSPDSTLLATCSADQTCKIW 247 +S +S + S+D+ +W Sbjct: 274 GVAWSRNSRFVGAGSSDKNVYVW 296 Score = 51.6 bits (122), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 52/242 (21%), Positives = 99/242 (40%), Gaps = 21/242 (8%) Query: 11 DPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDL 70 D ++ + D + W A SG R + VNAL+V S + + M Sbjct: 104 DSRVVYCSSSDTHLMSWDAVSGQKIRKHKGHAGVVNALDVLKVGSELLTSVSDDCTMKVW 163 Query: 71 NSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAP 130 +S + + I + + + +V + G ++ GG D +IWDL RN C + + + Sbjct: 164 DSRSKDCIKTIEE-KYPLTAVAIAQQGTQVFIGGIDGAIKIWDL--RNNHCSHVLKGHKD 220 Query: 131 -INCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQ--------LIPEPEVSITSAHIDPD 181 I + + + + L+ + I+D+K + Q I E ++ + Sbjct: 221 IITSLAISKDGSSLLSNSMDNTVRIFDVKPFASAQRQLQIFEGAIHGQEHNLLGVAWSRN 280 Query: 182 ASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSAD 241 + ++ A +S N YVW+ TG + + +P H F P ++ +CS+D Sbjct: 281 SRFVGAGSSDKNVYVWSATGDL---------RYVLPGHEGSVNHVDFHPHQDIILSCSSD 331 Query: 242 QT 243 +T Sbjct: 332 RT 333 Score = 38.1 bits (87), Expect = 0.006, Method: Compositional matrix adjust. Identities = 26/108 (24%), Positives = 46/108 (42%), Gaps = 7/108 (6%) Query: 211 IPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSR 270 +P ++ HT L RF P + A+ D+ +W F + + +G + Sbjct: 41 VPNLQMFGHTAEVLVARFDPSGSYFASGGMDRQILLWNV--FGDVKNYGVLNG-----CK 93 Query: 271 GWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCL 318 G + +S DS+ + +SSD W +G+ R++ GH V L Sbjct: 94 GAITDLQWSRDSRVVYCSSSDTHLMSWDAVSGQKIRKHKGHAGVVNAL 141 >5FL8-q nrPDB Length = 515 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 71/323 (21%), Positives = 129/323 (39%), Gaps = 48/323 (14%) Query: 11 DPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQ-VNALEVTP-------DRSMIAAAGY 62 D ++AT D+T+R W SG C S+ + +L P + +A++ Sbjct: 197 DGEVIATGSMDNTIRLWDPKSGQCLGDALRGHSKWITSLSWEPIHLVKPGSKPRLASSSK 256 Query: 63 Q-HIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQC 121 I+++D S +S G +++ V + G +Y+G D T R+WD+ S+ +C Sbjct: 257 DGTIKIWDTVSRVCQYTMS--GHTNSVSCVKWGGQGL-LYSGSHDRTVRVWDINSQG-RC 312 Query: 122 QRIFQVNAP-INCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDP 180 I + +A +N + L + A I GA DH + PE A Sbjct: 313 INILKSHAHWVNHLSLSTDYALRI-----GAF-------DHTGKKPSTPE----EAQKKA 356 Query: 181 DASYMAAVNSTGNCYVWNLTGGIGDEVTQLI--------PKTKIPAHTRYALQCRFSPDS 232 +Y GN +T D+ T + P ++ H + FSPD Sbjct: 357 LENYEKICKKNGNSEEMMVTAS--DDYTMFLWNPLKSTKPIARMTGHQKLVNHVAFSPDG 414 Query: 233 TLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDN 292 + + S D + K+W + ++ + ++ A+S D + +V+ S D Sbjct: 415 RYIVSASFDNSIKLWDGRDGKFISTFRGHVAS--------VYQVAWSSDCRLLVSCSKDT 466 Query: 293 LARLWCVETGEIKREYGGHQKAV 315 ++W V T ++ + GH+ V Sbjct: 467 TLKVWDVRTRKLSVDLPGHKDEV 489 Score = 45.4 bits (106), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 59/294 (20%), Positives = 115/294 (39%), Gaps = 31/294 (10%) Query: 9 GSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMY 68 GS P LA++ D T++ W S +C T+ + V+ ++ + + + + +R++ Sbjct: 246 GSKPR-LASSSKDGTIKIWDTVSRVCQYTMSGHTNSVSCVKWGGQGLLYSGSHDRTVRVW 304 Query: 69 DLNSNNP--NPIISYDG-VNKNIASVGFH-EDGRWMYTGGEDCTARIWDLRSRNLQCQRI 124 D+NS N + S+ VN S + G + +TG + T + Q+ Sbjct: 305 DINSQGRCINILKSHAHWVNHLSLSTDYALRIGAFDHTGKKPSTPE---------EAQKK 355 Query: 125 FQVNAPINCVCLHPNQAELIVGDQSGAIHIWD-LKTDHNEQLIPEPEVSITSAHIDPDAS 183 N C ++ ++ + +W+ LK+ + + + PD Sbjct: 356 ALENYEKICKKNGNSEEMMVTASDDYTMFLWNPLKSTKPIARMTGHQKLVNHVAFSPDGR 415 Query: 184 YMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQT 243 Y+ + + + +W+ G G ++ H Q +S D LL +CS D T Sbjct: 416 YIVSASFDNSIKLWD--GRDGKFISTF------RGHVASVYQVAWSSDCRLLVSCSKDTT 467 Query: 244 CKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLW 297 K+W L +L PG ++ +S D + + + D + RLW Sbjct: 468 LKVWDVRTRKLSVDL------PGHKDE--VYTVDWSVDGKRVCSGGKDKMVRLW 513 Score = 42.7 bits (99), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 78/323 (24%), Positives = 125/323 (38%), Gaps = 44/323 (13%) Query: 15 LATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQH-IRMYDLNSN 73 + T D+T R W + T++ + V + +PD +IA + IR++D S Sbjct: 159 MVTGAGDNTARIWDCDTQTPMHTLKGHYNWVLCVSWSPDGEVIATGSMDNTIRLWDPKSG 218 Query: 74 NPNPIISYDGVNKNIASVGFHE-------DGRWMYTGGEDCTARIWDLRSRNLQCQRIFQ 126 + G +K I S+ + + + +D T +IWD SR Q Sbjct: 219 QCLGD-ALRGHSKWITSLSWEPIHLVKPGSKPRLASSSKDGTIKIWDTVSRVCQYTMSGH 277 Query: 127 VNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMA 186 N+ ++CV Q L G + +WD+ N Q I+ S+ Sbjct: 278 TNS-VSCVKWG-GQGLLYSGSHDRTVRVWDI----NSQ----------GRCINILKSHAH 321 Query: 187 AVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTR----YALQCRFSPDST-LLATCSAD 241 VN + L G D T P T A + Y C+ + +S ++ T S D Sbjct: 322 WVNHLSLSTDYALRIGAFDH-TGKKPSTPEEAQKKALENYEKICKKNGNSEEMMVTASDD 380 Query: 242 QTCKIWRTSNFSLMTELSIKSGNPGESSRG---WMWGCAFSGDSQYIVTASSDNLARLWC 298 T +W +KS P G + AFS D +YIV+AS DN +LW Sbjct: 381 YTMFLWN----------PLKSTKPIARMTGHQKLVNHVAFSPDGRYIVSASFDNSIKLWD 430 Query: 299 VETGEIKREYGGHQKAVVCLAFN 321 G+ + GH +V +A++ Sbjct: 431 GRDGKFISTFRGHVASVYQVAWS 453 Score = 28.5 bits (62), Expect = 3.7, Method: Compositional matrix adjust. Identities = 13/40 (32%), Positives = 22/40 (55%) Query: 282 SQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFN 321 S +VT + DN AR+W +T GH V+C++++ Sbjct: 156 SSRMVTGAGDNTARIWDCDTQTPMHTLKGHYNWVLCVSWS 195 >1NR0-A nrPDB Length = 611 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 62/247 (25%), Positives = 101/247 (40%), Gaps = 22/247 (8%) Query: 75 PNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCV 134 P IS+D +K IA+VG +GR + ++ + Q A +N V Sbjct: 105 PVKDISWDSESKRIAAVG---EGRERF-------GHVFLFDTGTSNGNLTGQARA-MNSV 153 Query: 135 CLHPNQA-ELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGN 193 P++ +I G + I++ + E + S +PD S A+ G Sbjct: 154 DFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGT 213 Query: 194 CYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFS 253 ++N G V + K AH+ +SPD T +A+ SAD+T KIW + + Sbjct: 214 IVLYNGVDGTKTGVFE-DDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVA--T 270 Query: 254 LMTELSIKSGNPGESSR-GWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQ 312 L E +I G E + G +W Q +V+ S++ E G I + GH Sbjct: 271 LKVEKTIPVGTRIEDQQLGIIW------TKQALVSISANGFINFVNPELGSIDQVRYGHN 324 Query: 313 KAVVCLA 319 KA+ L+ Sbjct: 325 KAITALS 331 Score = 38.5 bits (88), Expect = 0.004, Method: Compositional matrix adjust. Identities = 59/258 (22%), Positives = 89/258 (34%), Gaps = 61/258 (23%) Query: 43 SQVNALEVTPDRSMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYT 102 SQ L V+ D + AA Y+HI +Y PI SY N + V D +++ Sbjct: 412 SQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPI-SY-----NSSCVALSNDKQFVAV 465 Query: 103 GGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHN 162 GG+D ++ L ++ + A I V N A L+ DQS Sbjct: 466 GGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQS------------- 512 Query: 163 EQLIPEPEVSITSAHIDPDASYMAAVN-STGNCYVWNLTGGIGDEVTQLIPKTKIPAHTR 221 ++IP Y A N + W HT Sbjct: 513 RKVIP----------------YSVANNFELAHTNSWTF-------------------HTA 537 Query: 222 YALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGD 281 +SPD+ LAT S D + +W + S + IK + S +W + Sbjct: 538 KVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDH-PIIIKGAHAMSSVNSVIW-----LN 591 Query: 282 SQYIVTASSDNLARLWCV 299 IV+A D+ + W V Sbjct: 592 ETTIVSAGQDSNIKFWNV 609 Score = 31.6 bits (70), Expect = 0.54, Method: Compositional matrix adjust. Identities = 43/216 (19%), Positives = 88/216 (40%), Gaps = 12/216 (5%) Query: 10 SDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQ-HIRMY 68 S P + + D+TV ++ T V+++ PD S+ A+ G I +Y Sbjct: 158 SRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLY 217 Query: 69 DLNSNNPNPIISYDGVNKNIASVG------FHEDGRWMYTGGEDCTARIWDLRSRNLQCQ 122 + + D + KN+A G + DG + + D T +IW++ + L+ + Sbjct: 218 NGVDGTKTGVFEDDSL-KNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVAT--LKVE 274 Query: 123 RIFQVNAPINCVCLHP--NQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDP 180 + V I L + L+ +G I+ + + +Q+ +IT+ Sbjct: 275 KTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSA 334 Query: 181 DASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKI 216 D + + ++ G+ W+++ GI + V + T I Sbjct: 335 DGKTLFSADAEGHINSWDISTGISNRVFPDVHATMI 370 >4AEZ-A nrPDB Length = 401 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 50/185 (27%), Positives = 74/185 (40%), Gaps = 31/185 (16%) Query: 78 IISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLH 137 I + G + + + + DG + +GG D +IWD RS + + NA + V Sbjct: 210 IGTLQGHSSEVCGLAWRSDGLQLASGGNDNVVQIWDARSSIPKFTKTNH-NAAVKAVAWC 268 Query: 138 PNQAELIV---GDQSGAIHIWDLKT-------DHNEQ---LIPEPEVS-ITSAHIDPDAS 183 P Q+ L+ G IH W+ T D Q LI P I S H PD Sbjct: 269 PWQSNLLATGGGTMDKQIHFWNAATGARVNTVDAGSQVTSLIWSPHSKEIMSTHGFPD-- 326 Query: 184 YMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQT 243 N +W+ + + L + IPAH L SPD +L+T ++D+ Sbjct: 327 --------NNLSIWSYSS------SGLTKQVDIPAHDTRVLYSALSPDGRILSTAASDEN 372 Query: 244 CKIWR 248 K WR Sbjct: 373 LKFWR 377 Score = 29.3 bits (64), Expect = 2.3, Method: Compositional matrix adjust. Identities = 15/48 (31%), Positives = 24/48 (50%) Query: 278 FSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDSVL 325 +S D ++ + L ++ VE+ R GHQ V CL++N VL Sbjct: 142 WSHDGSFLSVGLGNGLVDIYDVESQTKLRTMAGHQARVGCLSWNRHVL 189 Score = 28.9 bits (63), Expect = 3.4, Method: Compositional matrix adjust. Identities = 25/103 (24%), Positives = 50/103 (48%), Gaps = 4/103 (3%) Query: 56 MIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLR 115 ++A A +++ +++ +S + + + D + +ASV + DG ++ G + I+D+ Sbjct: 106 VVAVALERNVYVWNADSGSVSALAETDE-STYVASVKWSHDGSFLSVGLGNGLVDIYDVE 164 Query: 116 SRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLK 158 S Q + CL N+ L G +SGAIH D++ Sbjct: 165 S---QTKLRTMAGHQARVGCLSWNRHVLSSGSRSGAIHHHDVR 204 >6G51-g nrPDB Length = 317 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 71/321 (22%), Positives = 124/321 (38%), Gaps = 63/321 (19%) Query: 12 PVILATAGYDHTVRFW-----QAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQ-HI 65 P ++ +A D T+ W + + GI R ++ V+ + ++ D + + + Sbjct: 28 PDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTL 87 Query: 66 RMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIF 125 R++DL + + G K++ SV F D R + +G D T ++W+ C+ Sbjct: 88 RLWDLTTGTTTR--RFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLG---VCKYTV 142 Query: 126 QVNAP---INCVCLHPNQAELIVGD--QSGAIHIWD-----LKTDHNEQLIPEPEVSITS 175 Q + ++CV PN + I+ + +W+ LKT+H + + Sbjct: 143 QDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGH-----TGYLNT 197 Query: 176 AHIDPDASYMAAVNSTGNCYVWNLTGGI-------GDEVTQLIPKTKIPAHTRYALQCRF 228 + PD S A+ G +W+L G GD + L F Sbjct: 198 VTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALC----------------F 241 Query: 229 SPDSTLLATCSADQTCKIWRTSNFSLMTEL-------SIKSGNPGESSRGWMWGCAFSGD 281 SP+ L + + KIW ++ EL S K+ P +S W S D Sbjct: 242 SPNRYWLCAATG-PSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAW------SAD 294 Query: 282 SQYIVTASSDNLARLWCVETG 302 Q + +DNL R+W V G Sbjct: 295 GQTLFAGYTDNLVRVWQVTIG 315 Score = 45.1 bits (105), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 30/117 (25%), Positives = 53/117 (45%), Gaps = 10/117 (8%) Query: 209 QLIPKTKIPAHTRYALQCRFSPD-STLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGE 267 Q+ + + H + Q +P ++ + S D+T +W+ +T G P Sbjct: 4 QMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWK------LTRDETNYGIPQR 57 Query: 268 SSRG---WMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFN 321 + RG ++ S D Q+ ++ S D RLW + TG R + GH K V+ +AF+ Sbjct: 58 ALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFS 114 Score = 45.1 bits (105), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 43/192 (22%), Positives = 75/192 (39%), Gaps = 23/192 (11%) Query: 128 NAPINCVCLHPNQAELIV-GDQSGAIHIWDLKTDHNEQLIPEPEVS-----ITSAHIDPD 181 N + + P ++I+ + I +W L D IP+ + ++ I D Sbjct: 15 NGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSD 74 Query: 182 ASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSAD 241 + + + G +W+LT G + HT+ L FS D+ + + S D Sbjct: 75 GQFALSGSWDGTLRLWDLTTGTTTR--------RFVGHTKDVLSVAFSSDNRQIVSGSRD 126 Query: 242 QTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQ--YIVTASSDNLARLWCV 299 +T K+W T T ES W+ FS +S IV+ D L ++W + Sbjct: 127 KTIKLWNTLGVCKYTV-------QDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNL 179 Query: 300 ETGEIKREYGGH 311 ++K + GH Sbjct: 180 ANCKLKTNHIGH 191 >6GMH-W nrPDB Length = 305 Score = 55.5 bits (132), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 52/228 (22%), Positives = 86/228 (37%), Gaps = 19/228 (8%) Query: 95 EDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHI 154 E+ + TG D ++W R L Q + + V + + I S HI Sbjct: 30 ENSETVVTGSLDDLVKVWKWRDERLDLQWSLE-GHQLGVVSVDISHTLPIAASSSLDAHI 88 Query: 155 --WDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIP 212 WDL+ + I V + PD+ Y+A G ++ + G Sbjct: 89 RLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGK--------K 140 Query: 213 KTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGW 272 + + ++ L +SPD LA+ + D I+ + L+ L P S Sbjct: 141 EYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLE-GHAMPIRS---- 195 Query: 273 MWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAF 320 FS DSQ +VTAS D +++ V+ + GH V+ +AF Sbjct: 196 ---LTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAF 240 Score = 50.8 bits (120), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 56/219 (25%), Positives = 95/219 (43%), Gaps = 23/219 (10%) Query: 106 DCTARIWDLRSRNLQCQRIFQVNA-PINC--VCLHPNQAELIVGDQSGAIHIWDLKTDHN 162 D R+WDL + ++I ++A P++ + P+ L G G ++I+ +++ Sbjct: 85 DAHIRLWDLEN----GKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKK 140 Query: 163 EQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRY 222 E + I S PD Y+A+ G ++++ G +L+ + H Sbjct: 141 EYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATG------KLLHT--LEGHAMP 192 Query: 223 ALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDS 282 FSPDS LL T S D KI+ + +L LS G +S W+ AF D Sbjct: 193 IRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLS------GHAS--WVLNVAFCPDD 244 Query: 283 QYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFN 321 + V++SSD ++W V T + HQ V + +N Sbjct: 245 THFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYN 283 Score = 43.9 bits (102), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 31/146 (21%), Positives = 61/146 (41%), Gaps = 4/146 (2%) Query: 14 ILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGY-QHIRMYDLNS 72 I A++ D +R W +G +++ L +PD +A + + ++ + S Sbjct: 78 IAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVES 137 Query: 73 NNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPIN 132 S D K I S+ + DG+++ +G D I+D+ + L + PI Sbjct: 138 GKKE--YSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKL-LHTLEGHAMPIR 194 Query: 133 CVCLHPNQAELIVGDQSGAIHIWDLK 158 + P+ L+ G I I+D++ Sbjct: 195 SLTFSPDSQLLVTASDDGYIKIYDVQ 220 >4V7E-Bg nrPDB Length = 380 Score = 55.5 bits (132), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 54/229 (23%), Positives = 92/229 (40%), Gaps = 17/229 (7%) Query: 35 TRTVQHQDSQVNALEVTPDRS--MIAAAGYQHIRMYDLNSNNPNPIISYD---GVNKNIA 89 +R + ++ + PD+ +I +G Q ++D+ + I + G ++ Sbjct: 150 SRVLTGHKGYASSCQYVPDQETRLITGSGDQTCVLWDVTTGQRISIFGSEFPSGHTADVL 209 Query: 90 SVGFHEDGRWMYTGGE-DCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQ 148 S+ + M+ G D T R+WDLR + + IN V P+ G Sbjct: 210 SLSINSLNANMFISGSCDTTVRLWDLRITSRAVRTYHGHEGDINSVKFFPDGQRFGTGSD 269 Query: 149 SGAIHIWDLKTDHNEQLI-PEPEVS------ITSAHIDPDASYMAAVNSTGNCYVWNLTG 201 G ++D++T H Q+ EP+ + +TS + A S G+CYVW+ Sbjct: 270 DGTCRLFDMRTGHQLQVYNREPDRNDNELPIVTSVAFSISGRLLFAGYSNGDCYVWDTL- 328 Query: 202 GIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTS 250 + + V L T +H S D + L T S D+ KIW S Sbjct: 329 -LAEMVLNL--GTLQNSHEGRISCLGLSSDGSALCTGSWDKNLKIWAFS 374 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 70/342 (20%), Positives = 121/342 (35%), Gaps = 77/342 (22%) Query: 33 ICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVG 92 +C RT+Q +V +L+ TP+++ I +A Q R+ N+ + + Sbjct: 57 VCCRTLQGHSGKVYSLDWTPEKNWIVSAS-QDGRLIVWNALTSQKTHAIKLHCPWVMECA 115 Query: 93 FHEDGRWMYTGGEDCTARIWDLRSR-----NLQCQRIFQVNAPINCVCLH-PNQAELIV- 145 F +G+ + GG D I++L S+ N+ R+ + C + P+Q ++ Sbjct: 116 FAPNGQSVACGGLDSACSIFNLSSQADRDGNMPVSRVLTGHKGYASSCQYVPDQETRLIT 175 Query: 146 --GDQ------------------------------------------SGA----IHIWDL 157 GDQ SG+ + +WDL Sbjct: 176 GSGDQTCVLWDVTTGQRISIFGSEFPSGHTADVLSLSINSLNANMFISGSCDTTVRLWDL 235 Query: 158 K-TDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIP---K 213 + T + E I S PD + G C ++++ G +V P Sbjct: 236 RITSRAVRTYHGHEGDINSVKFFPDGQRFGTGSDDGTCRLFDMRTGHQLQVYNREPDRND 295 Query: 214 TKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWM 273 ++P T A FS LL ++ C +W T L+ E+ + G S G + Sbjct: 296 NELPIVTSVA----FSISGRLLFAGYSNGDCYVWDT----LLAEMVLNLGTLQNSHEGRI 347 Query: 274 WGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAV 315 S D + T S D ++W + GH+K V Sbjct: 348 SCLGLSSDGSALCTGSWDKNLKIW---------AFSGHRKIV 380 >2YNP-A nrPDB Length = 604 Score = 54.7 bits (130), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 61/292 (20%), Positives = 115/292 (39%), Gaps = 22/292 (7%) Query: 10 SDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYD 69 ++P +L T Y V W + + R++Q ++ V A + ++ I G R+ Sbjct: 24 TEPWVLTTL-YSGRVELWNYETQVEVRSIQVTETPVRAGKFIARKNWIIV-GSDDFRIRV 81 Query: 70 LNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNA 129 N N ++ ++ I S+ H ++ +G +D T ++W+ + N ++ F+ + Sbjct: 82 FNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWNWEN-NWALEQTFEGHE 140 Query: 130 P-INCVCLHPNQ-AELIVGDQSGAIHIWDL-KTDHNEQLIPEPE--VSITSAHIDPDASY 184 + CV +P + G + +W L ++ N L E V+ + PD Y Sbjct: 141 HFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQERGVNYVDYYPLPDKPY 200 Query: 185 MAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTC 244 M + +LT I D T+ T + H F P ++ + S D T Sbjct: 201 MITASD-------DLTIKIWDYQTKSCVAT-LEGHMSNVSFAVFHPTLPIIISGSEDGTL 252 Query: 245 KIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARL 296 KIW +S + + L++ R W +G YI + + L Sbjct: 253 KIWNSSTYKVEKTLNVG------LERSWCIATHPTGRKNYIASGFDNGFTVL 298 Score = 42.0 bits (97), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 48/243 (19%), Positives = 87/243 (35%), Gaps = 24/243 (9%) Query: 88 IASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGD 147 + + FH W+ T +W+ ++ ++ + I P+ + +IVG Sbjct: 16 VKGIDFHPTEPWVLTTLYSGRVELWNYETQ-VEVRSIQVTETPVRAGKFIARKNWIIVGS 74 Query: 148 QSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEV 207 I +++ T I S + P Y+ + + +WN E Sbjct: 75 DDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWNWENNWALEQ 134 Query: 208 TQLIPKTKIPAHTRYALQCRFSP-DSTLLATCSADQTCKIWR----TSNFSLMTELSIKS 262 T H + + F+P D + A+ D+T K+W T NF+L T Sbjct: 135 T-------FEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTG----- 182 Query: 263 GNPGESSRGWMWGCAFS-GDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFN 321 RG + + D Y++TAS D ++W +T GH V F+ Sbjct: 183 -----QERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAVFH 237 Query: 322 DSV 324 ++ Sbjct: 238 PTL 240 >6EOJ-D nrPDB Length = 470 Score = 54.3 bits (129), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 43/177 (24%), Positives = 73/177 (41%), Gaps = 16/177 (9%) Query: 126 QVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYM 185 +V I + P L+V SG +W+ + E L+ + ++T+ D+ +M Sbjct: 91 KVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWM 150 Query: 186 AAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCK 245 + ++ G +W + E+ AHT FS + + TCS D K Sbjct: 151 ISGDADGMIKIWQPNFSMVKEIDA--------AHTESIRDMAFSSNDSKFVTCSDDNILK 202 Query: 246 IWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETG 302 IW NFS + + SG+ + C + + I +AS DNL +LW +G Sbjct: 203 IW---NFSNGKQERVLSGHHWDVK-----SCDWHPEMGLIASASKDNLVKLWDPRSG 251 Score = 48.9 bits (115), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 35/133 (26%), Positives = 56/133 (42%), Gaps = 16/133 (12%) Query: 180 PDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCS 239 P+ + +G +WN + + + Q AH ++S DS + + Sbjct: 103 PEGRRLVVATYSGEFSLWNASSFTFETLMQ--------AHDSAVTTMKYSHDSDWMISGD 154 Query: 240 ADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCV 299 AD KIW+ NFS++ E+ ES R AFS + VT S DN+ ++W Sbjct: 155 ADGMIKIWQ-PNFSMVKEIDAAHT---ESIRD----MAFSSNDSKFVTCSDDNILKIWNF 206 Query: 300 ETGEIKREYGGHQ 312 G+ +R GH Sbjct: 207 SNGKQERVLSGHH 219 Score = 38.5 bits (88), Expect = 0.004, Method: Compositional matrix adjust. Identities = 43/238 (18%), Positives = 93/238 (39%), Gaps = 24/238 (10%) Query: 16 ATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPD-RSMIAAAGYQHIRMYDLNSNN 74 A G D + + + + V+H + A++ TP+ R ++ A +++ +S Sbjct: 70 AYRGRDRVINLPSKFTHLSSNKVKHV---IPAIQWTPEGRRLVVATYSGEFSLWNASSFT 126 Query: 75 PNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAP---- 130 ++ + + ++ + D WM +G D +IW + +++A Sbjct: 127 FETLMQ--AHDSAVTTMKYSHDSDWMISGDADGMIKIW-----QPNFSMVKEIDAAHTES 179 Query: 131 INCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNS 190 I + N ++ + + IW+ E+++ + S P+ +A+ + Sbjct: 180 IRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASK 239 Query: 191 TGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSP-DSTLLATCSADQTCKIW 247 +W+ G I K K HT L+ RF P LL S D++C+++ Sbjct: 240 DNLVKLWDPRSG---NCISSILKFK---HT--VLKTRFQPTKGNLLMAISKDKSCRVF 289 Score = 33.1 bits (74), Expect = 0.17, Method: Compositional matrix adjust. Identities = 37/231 (16%), Positives = 91/231 (39%), Gaps = 13/231 (5%) Query: 21 DHTVRFWQAHSGICTRT-VQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLNSNNPNPII 79 D ++ WQ + + H +S + + D + + +++++ ++ ++ Sbjct: 156 DGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVL 215 Query: 80 SYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPN 139 S G + ++ S +H + + + +D ++WD RS N I + + P Sbjct: 216 S--GHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNC-ISSILKFKHTVLKTRFQPT 272 Query: 140 QAELIVG-DQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDP-DASYMAAVNSTGNCYVW 197 + L++ + + ++D++ E + E + P + S G+ + Sbjct: 273 KGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHF 332 Query: 198 NLTGGIGDEVTQLIPKTKIP-AHTRYALQCRFSPDSTLLATCSADQTCKIW 247 +L + + P IP AH + ++P + AT + D+T + W Sbjct: 333 DLLQNLNE------PILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFW 377 Score = 32.0 bits (71), Expect = 0.34, Method: Compositional matrix adjust. Identities = 35/165 (21%), Positives = 67/165 (40%), Gaps = 33/165 (20%) Query: 165 LIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGI----GDEVTQLIPKTKIPAHT 220 L+ EPE S T + P+A G V NL ++V +IP Sbjct: 53 LVVEPETSYTIDIMPPNAY-------RGRDRVINLPSKFTHLSSNKVKHVIP-------- 97 Query: 221 RYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSG 280 A+Q ++P+ L + +W S+F+ T + ++ + +S Sbjct: 98 --AIQ--WTPEGRRLVVATYSGEFSLWNASSFTFETLM--------QAHDSAVTTMKYSH 145 Query: 281 DSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAF--NDS 323 DS ++++ +D + ++W +K H +++ +AF NDS Sbjct: 146 DSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDS 190 >3MKQ-A nrPDB Length = 814 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 61/292 (20%), Positives = 115/292 (39%), Gaps = 22/292 (7%) Query: 10 SDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYD 69 ++P +L T Y V W + + R++Q ++ V A + ++ I G R+ Sbjct: 24 TEPWVLTTL-YSGRVEIWNYETQVEVRSIQVTETPVRAGKFIARKNWIIV-GSDDFRIRV 81 Query: 70 LNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNA 129 N N ++ ++ I S+ H ++ +G +D T ++W+ + N ++ F+ + Sbjct: 82 FNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWNWEN-NWALEQTFEGHE 140 Query: 130 P-INCVCLHPNQ-AELIVGDQSGAIHIWDL-KTDHNEQLIPEPE--VSITSAHIDPDASY 184 + CV +P + G + +W L ++ N L E V+ + PD Y Sbjct: 141 HFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQERGVNYVDYYPLPDKPY 200 Query: 185 MAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTC 244 M + +LT I D T+ T + H F P ++ + S D T Sbjct: 201 MITASD-------DLTIKIWDYQTKSCVAT-LEGHMSNVSFAVFHPTLPIIISGSEDGTL 252 Query: 245 KIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARL 296 KIW +S + + L++ R W +G YI + + L Sbjct: 253 KIWNSSTYKVEKTLNVG------LERSWCIATHPTGRKNYIASGFDNGFTVL 298 Score = 41.6 bits (96), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 49/243 (20%), Positives = 87/243 (35%), Gaps = 24/243 (9%) Query: 88 IASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGD 147 + + FH W+ T IW+ ++ ++ + I P+ + +IVG Sbjct: 16 VKGIDFHPTEPWVLTTLYSGRVEIWNYETQ-VEVRSIQVTETPVRAGKFIARKNWIIVGS 74 Query: 148 QSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEV 207 I +++ T I S + P Y+ + + +WN E Sbjct: 75 DDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWNWENNWALEQ 134 Query: 208 TQLIPKTKIPAHTRYALQCRFSP-DSTLLATCSADQTCKIWR----TSNFSLMTELSIKS 262 T H + + F+P D + A+ D+T K+W T NF+L T Sbjct: 135 T-------FEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTG----- 182 Query: 263 GNPGESSRGWMWGCAFS-GDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFN 321 RG + + D Y++TAS D ++W +T GH V F+ Sbjct: 183 -----QERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAVFH 237 Query: 322 DSV 324 ++ Sbjct: 238 PTL 240 >6N9G-C nrPDB Length = 353 Score = 51.6 bits (122), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 34/156 (21%), Positives = 65/156 (41%), Gaps = 5/156 (3%) Query: 1 MNTSPGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAA 60 ++ +P G+ V + G D W SG C + + +S VN++ P A+ Sbjct: 201 LDLAPSETGNTFV---SGGCDKKAMVWDMRSGQCVQAFETHESDVNSVRYYPSGDAFASG 257 Query: 61 GYQHI-RMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNL 119 R+YDL ++ I S + + +SV F GR ++ G D T +WD+ + Sbjct: 258 SDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVL-KGS 316 Query: 120 QCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIW 155 + +F ++ + + P+ G + +W Sbjct: 317 RVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352 Score = 48.1 bits (113), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 44/198 (22%), Positives = 79/198 (39%), Gaps = 13/198 (6%) Query: 53 DRSMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIW 112 D ++ A+G ++D+ S G + + E G +GG D A +W Sbjct: 165 DMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVW 224 Query: 113 DLRSRNLQCQRIFQVN-APINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEV 171 D+RS QC + F+ + + +N V +P+ G ++DL+ D + + + Sbjct: 225 DMRSG--QCVQAFETHESDVNSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESI 282 Query: 172 SITSAHIDPDAS--YMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFS 229 ++ +D S + A + VW++ G V+ L H R S Sbjct: 283 IFGASSVDFSLSGRLLFAGYNDYTINVWDVLKG--SRVSILF------GHENRVSTLRVS 334 Query: 230 PDSTLLATCSADQTCKIW 247 PD T + S D T ++W Sbjct: 335 PDGTAFCSGSWDHTLRVW 352 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 36/178 (20%), Positives = 65/178 (36%), Gaps = 8/178 (4%) Query: 138 PNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVW 197 ++ ++ Q G + +WD T + E + P + + P +A C V+ Sbjct: 73 KDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVY 132 Query: 198 NLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTE 257 LT + + K + HT Y C F+ + T S D TC +W + L+ Sbjct: 133 PLTFDKNENMAA--KKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQS 190 Query: 258 LSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAV 315 G + A S V+ D A +W + +G+ + + H+ V Sbjct: 191 F------HGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDV 242 Score = 44.3 bits (103), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 26/105 (24%), Positives = 49/105 (46%), Gaps = 2/105 (1%) Query: 222 YALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGD 281 + + C ++P +A D C ++ + F ++ K + + ++ C+F+ Sbjct: 107 WVMACAYAPSGCAIACGGLDNKCSVYPLT-FDKNENMAAKKKSVAMHTN-YLSACSFTNS 164 Query: 282 SQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDSVLG 326 I+TAS D LW VE+G++ + + GH V+CL S G Sbjct: 165 DMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETG 209 >4LG8-A nrPDB Length = 354 Score = 51.6 bits (122), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 40/186 (21%), Positives = 77/186 (41%), Gaps = 5/186 (2%) Query: 14 ILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEV--TPDRSMIAAAGYQHIRMYDLN 71 ++ +A D T+R W + C + V+ +S V L + T D +++++ Q+ D+ Sbjct: 128 LVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDY-LLSSSDDQYWAFSDIQ 186 Query: 72 SNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPI 131 + ++ + ++ FH DG TG D +IWDL+ R + PI Sbjct: 187 TGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERT-NVANFPGHSGPI 245 Query: 132 NCVCLHPNQAELIVGDQSGAIHIWDLKTDHN-EQLIPEPEVSITSAHIDPDASYMAAVNS 190 + N L ++ +WDL+ N + L + + S D +Y+A + Sbjct: 246 TSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGT 305 Query: 191 TGNCYV 196 Y+ Sbjct: 306 DVQIYI 311 Score = 49.3 bits (116), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 48/204 (23%), Positives = 86/204 (42%), Gaps = 19/204 (9%) Query: 96 DGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIW 155 D + TGG D ++D S + + + V HP+Q + I IW Sbjct: 83 DTNKILTGGADKNVVVFDKSSEQI-LATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIW 141 Query: 156 DLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTG-GIGDEVTQLIPKT 214 + Q++ E ++T + Y+ ++S+ + Y W + G +T++ +T Sbjct: 142 SVPNASCVQVVRAHESAVTGLSLHATGDYL--LSSSDDQY-WAFSDIQTGRVLTKVTDET 198 Query: 215 KIPAHTRYALQC-RFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWM 273 + +L C +F PD + T + D KIW + E + + PG S G + Sbjct: 199 -----SGCSLTCAQFHPDGLIFGTGTMDSQIKIWD------LKERTNVANFPGHS--GPI 245 Query: 274 WGCAFSGDSQYIVTASSDNLARLW 297 AFS + Y+ TA+ D+ +LW Sbjct: 246 TSIAFSENGYYLATAADDSSVKLW 269 Score = 42.0 bits (97), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 47/219 (21%), Positives = 87/219 (39%), Gaps = 20/219 (9%) Query: 45 VNALEVTP-DRSMIAAAGY-QHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYT 102 + AL++ P D + I G +++ ++D +S + + G K + SV FH +++ Sbjct: 74 ILALDLCPSDTNKILTGGADKNVVVFDKSSEQI--LATLKGHTKKVTSVVFHPSQDLVFS 131 Query: 103 GGEDCTARIWDLRSRNLQCQRIFQVN-APINCVCLHPNQAELIVGDQSGAIHIWDLKTDH 161 D T RIW + N C ++ + + + + + LH L+ D++T Sbjct: 132 ASPDATIRIWSV--PNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGR 189 Query: 162 NEQLIPEPE--VSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAH 219 + + S+T A PD +W+L E T + P H Sbjct: 190 VLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDL-----KERTNV---ANFPGH 241 Query: 220 TRYALQCRFSPDSTLLATCSADQTCKIW---RTSNFSLM 255 + FS + LAT + D + K+W + NF + Sbjct: 242 SGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTL 280 Score = 39.3 bits (90), Expect = 0.002, Method: Compositional matrix adjust. Identities = 37/193 (19%), Positives = 77/193 (39%), Gaps = 6/193 (3%) Query: 10 SDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQH-IRMY 68 SD + T G D V + S T++ +V ++ P + ++ +A IR++ Sbjct: 82 SDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIW 141 Query: 69 DL-NSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQV 127 + N++ + +++ + + H G ++ + +D D+++ + + + Sbjct: 142 SVPNASCVQVVRAHESA---VTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDET 198 Query: 128 NA-PINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMA 186 + + C HP+ G I IWDLK N P ITS + Y+A Sbjct: 199 SGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLA 258 Query: 187 AVNSTGNCYVWNL 199 + +W+L Sbjct: 259 TAADDSSVKLWDL 271 Score = 30.0 bits (66), Expect = 1.3, Method: Compositional matrix adjust. Identities = 25/112 (22%), Positives = 46/112 (41%), Gaps = 15/112 (13%) Query: 199 LTGG------IGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNF 252 LTGG + D+ ++ I T + HT+ F P L+ + S D T +IW N Sbjct: 88 LTGGADKNVVVFDKSSEQILAT-LKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNA 146 Query: 253 SLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEI 304 S + + + + G + Y++++S D ++TG + Sbjct: 147 SCVQVV--------RAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRV 190 >1VYH-C nrPDB Length = 410 Score = 51.6 bits (122), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 40/193 (20%), Positives = 76/193 (39%), Gaps = 16/193 (8%) Query: 128 NAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAA 187 +P+ V HP + ++ + I +WD +T E+ + S+ D +A+ Sbjct: 108 RSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLAS 167 Query: 188 VNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIW 247 ++ +W+ G + I + H P+ + + S D+T K+W Sbjct: 168 CSADMTIKLWDFQG------FECI--RTMHGHDHNVSSVSIMPNGDHIVSASRDKTIKMW 219 Query: 248 RTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKRE 307 + T +K+ R W+ + D I + S+D R+W V T E K E Sbjct: 220 -----EVQTGYCVKTFT---GHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAE 271 Query: 308 YGGHQKAVVCLAF 320 H+ V C+++ Sbjct: 272 LREHRHVVECISW 284 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 51/291 (17%), Positives = 115/291 (39%), Gaps = 45/291 (15%) Query: 56 MIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLR 115 M++A+ I+++D + + + G ++ + F G+ + + D T ++WD + Sbjct: 123 MVSASEDATIKVWDYETGDFERTLK--GHTDSVQDISFDHSGKLLASCSADMTIKLWDFQ 180 Query: 116 SRNLQCQRIFQ-VNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSIT 174 +C R + ++ V + PN ++ + I +W+++T + + + Sbjct: 181 --GFECIRTMHGHDHNVSSVSIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVR 238 Query: 175 SAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQC-RFSPDST 233 + D + +A+ ++ VW V K ++ H R+ ++C ++P+S+ Sbjct: 239 MVRPNQDGTLIASCSNDQTVRVWV--------VATKECKAELREH-RHVVECISWAPESS 289 Query: 234 --------------------LLATCSADQTCKIWRTSN-FSLMTELSIKSGNPGESSRGW 272 L + S D+T K+W S LMT + W Sbjct: 290 YSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVG---------HDNW 340 Query: 273 MWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDS 323 + G F ++I++ + D R+W + + H+ V L F+ + Sbjct: 341 VRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKT 391 Score = 48.9 bits (115), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 47/285 (16%), Positives = 116/285 (40%), Gaps = 42/285 (14%) Query: 14 ILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGY-QHIRMYDLNS 72 +LA+ D T++ W C RT+ D V+++ + P+ I +A + I+M+++ + Sbjct: 164 LLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVSIMPNGDHIVSASRDKTIKMWEVQT 223 Query: 73 NNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPIN 132 + ++ G + + V ++DG + + D T R+W + ++ + + + + + Sbjct: 224 G--YCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAE-LREHRHVVE 280 Query: 133 CVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTG 192 C+ P + + + +G+ + + P P ++ + + Sbjct: 281 CISWAPESSYSSISEATGS--------ETKKSGKPGP--------------FLLSGSRDK 318 Query: 193 NCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNF 252 +W+++ G+ + L+ H + F + +C+ D+T ++W N Sbjct: 319 TIKMWDVSTGMC--LMTLV------GHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNK 370 Query: 253 SLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLW 297 M L+ + ++ F + Y+VT S D ++W Sbjct: 371 RCMKTLN--------AHEHFVTSLDFHKTAPYVVTGSVDQTVKVW 407 Score = 40.8 bits (94), Expect = 9e-04, Method: Compositional matrix adjust. Identities = 29/170 (17%), Positives = 70/170 (41%), Gaps = 26/170 (15%) Query: 11 DPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRS--------------- 55 D ++A+ D TVR W + C ++ V + P+ S Sbjct: 245 DGTLIASCSNDQTVRVWVVATKECKAELREHRHVVECISWAPESSYSSISEATGSETKKS 304 Query: 56 ------MIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTA 109 +++ + + I+M+D+++ +++ G + + V FH G+++ + +D T Sbjct: 305 GKPGPFLLSGSRDKTIKMWDVSTG--MCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTL 362 Query: 110 RIWDLRSRNLQCQRIFQVNAP-INCVCLHPNQAELIVGDQSGAIHIWDLK 158 R+WD +N +C + + + + H ++ G + +W+ + Sbjct: 363 RVWDY--KNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410 >6HHQ-h nrPDB Length = 319 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 61/312 (19%), Positives = 122/312 (39%), Gaps = 26/312 (8%) Query: 3 TSPGTVGSDPVILATAGYDHTVRFWQ-----AHSGICTRTVQHQDSQVNALEVTPDRSMI 57 TS T P +L +A D T+ W+ G+ R+ + V +T D + Sbjct: 21 TSLATSAGQPNLLLSASRDKTLISWKLTGDDQKFGVPVRSFKGHSHIVQDCTLTADGAYA 80 Query: 58 AAAGY-QHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRS 116 +A + + +R++D+ + + G ++ SV + + +G D T ++W ++ Sbjct: 81 LSASWDKTLRLWDVATGETYQ--RFVGHKSDVMSVDIDKKASMIISGSRDKTIKVWTIKG 138 Query: 117 RNLQCQRIFQVNAPINCVCLHPNQ------AELIVGDQSGAIHIWDLKTDHNEQLIPEPE 170 + L + N ++ V + PN+ +I + W+L E Sbjct: 139 QCLAT--LLGHNDWVSQVRVVPNEKADDDSVTIISAGNDKMVKAWNLNQFQIEADFIGHN 196 Query: 171 VSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSP 230 +I + PD + +A+ G +WNL + L + ++ FSP Sbjct: 197 SNINTLTASPDGTLIASAGKDGEIMLWNLAAK--KAMYTLSAQDEV-------FSLAFSP 247 Query: 231 DSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASS 290 + LA +A K++ L+ +L + +++ A+S D Q + + Sbjct: 248 NRYWLAAATA-TGIKVFSLDPQYLVDDLRPEFAGYSKAAEPHAVSLAWSADGQTLFAGYT 306 Query: 291 DNLARLWCVETG 302 DN+ R+W V T Sbjct: 307 DNVIRVWQVMTA 318 Score = 44.3 bits (103), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 31/126 (24%), Positives = 60/126 (47%), Gaps = 13/126 (10%) Query: 2 NTSPGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAG 61 N + T D ++A+AG D + W + T+ QD +V +L +P+R +AAA Sbjct: 198 NINTLTASPDGTLIASAGKDGEIMLWNLAAKKAMYTLSAQD-EVFSLAFSPNRYWLAAAT 256 Query: 62 YQHIRMYDLNSNNPNPII-----SYDGVNK----NIASVGFHEDGRWMYTGGEDCTARIW 112 I+++ L+ P ++ + G +K + S+ + DG+ ++ G D R+W Sbjct: 257 ATGIKVFSLD---PQYLVDDLRPEFAGYSKAAEPHAVSLAWSADGQTLFAGYTDNVIRVW 313 Query: 113 DLRSRN 118 + + N Sbjct: 314 QVMTAN 319 Score = 41.6 bits (96), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 28/88 (31%), Positives = 42/88 (47%), Gaps = 9/88 (10%) Query: 234 LLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRG---WMWGCAFSGDSQYIVTASS 290 LL + S D+T W+ +T K G P S +G + C + D Y ++AS Sbjct: 32 LLLSASRDKTLISWK------LTGDDQKFGVPVRSFKGHSHIVQDCTLTADGAYALSASW 85 Query: 291 DNLARLWCVETGEIKREYGGHQKAVVCL 318 D RLW V TGE + + GH+ V+ + Sbjct: 86 DKTLRLWDVATGETYQRFVGHKSDVMSV 113 Score = 28.5 bits (62), Expect = 4.2, Method: Compositional matrix adjust. Identities = 28/147 (19%), Positives = 56/147 (38%), Gaps = 23/147 (15%) Query: 178 IDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLAT 237 + D +Y + + +W++ G E Q + H + ++++ + Sbjct: 73 LTADGAYALSASWDKTLRLWDVATG---ETYQ-----RFVGHKSDVMSVDIDKKASMIIS 124 Query: 238 CSADQTCKIWRTSNFSLMTEL------SIKSGNPGESSRGWMWGCAFSGDSQYIVTASSD 291 S D+T K+W L T L S P E + DS I++A +D Sbjct: 125 GSRDKTIKVWTIKGQCLATLLGHNDWVSQVRVVPNEKA---------DDDSVTIISAGND 175 Query: 292 NLARLWCVETGEIKREYGGHQKAVVCL 318 + + W + +I+ ++ GH + L Sbjct: 176 KMVKAWNLNQFQIEADFIGHNSNINTL 202 >5Z56-q nrPDB Length = 504 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 40/186 (21%), Positives = 77/186 (41%), Gaps = 5/186 (2%) Query: 14 ILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEV--TPDRSMIAAAGYQHIRMYDLN 71 ++ +A D T+R W + C + V+ +S V L + T D +++++ Q+ D+ Sbjct: 278 LVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDY-LLSSSDDQYWAFSDIQ 336 Query: 72 SNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPI 131 + ++ + ++ FH DG TG D +IWDL+ R + PI Sbjct: 337 TGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERT-NVANFPGHSGPI 395 Query: 132 NCVCLHPNQAELIVGDQSGAIHIWDLKTDHN-EQLIPEPEVSITSAHIDPDASYMAAVNS 190 + N L ++ +WDL+ N + L + + S D +Y+A + Sbjct: 396 TSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGT 455 Query: 191 TGNCYV 196 Y+ Sbjct: 456 DVQIYI 461 Score = 48.9 bits (115), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 48/204 (23%), Positives = 85/204 (41%), Gaps = 19/204 (9%) Query: 96 DGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIW 155 D + TGG D ++D S + + V HP+Q + I IW Sbjct: 233 DTNKILTGGADKNVVVFDKSSEQILATLKGHTKK-VTSVVFHPSQDLVFSASPDATIRIW 291 Query: 156 DLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTG-GIGDEVTQLIPKT 214 + Q++ E ++T + Y+ ++S+ + Y W + G +T++ +T Sbjct: 292 SVPNASCVQVVRAHESAVTGLSLHATGDYL--LSSSDDQY-WAFSDIQTGRVLTKVTDET 348 Query: 215 KIPAHTRYALQC-RFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWM 273 + +L C +F PD + T + D KIW + E + + PG S G + Sbjct: 349 -----SGCSLTCAQFHPDGLIFGTGTMDSQIKIWD------LKERTNVANFPGHS--GPI 395 Query: 274 WGCAFSGDSQYIVTASSDNLARLW 297 AFS + Y+ TA+ D+ +LW Sbjct: 396 TSIAFSENGYYLATAADDSSVKLW 419 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 47/219 (21%), Positives = 87/219 (39%), Gaps = 20/219 (9%) Query: 45 VNALEVTP-DRSMIAAAGY-QHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYT 102 + AL++ P D + I G +++ ++D +S + + G K + SV FH +++ Sbjct: 224 ILALDLCPSDTNKILTGGADKNVVVFDKSSEQI--LATLKGHTKKVTSVVFHPSQDLVFS 281 Query: 103 GGEDCTARIWDLRSRNLQCQRIFQVN-APINCVCLHPNQAELIVGDQSGAIHIWDLKTDH 161 D T RIW + N C ++ + + + + + LH L+ D++T Sbjct: 282 ASPDATIRIWSV--PNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGR 339 Query: 162 NEQLIPEPE--VSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAH 219 + + S+T A PD +W+L E T + P H Sbjct: 340 VLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDL-----KERTNV---ANFPGH 391 Query: 220 TRYALQCRFSPDSTLLATCSADQTCKIW---RTSNFSLM 255 + FS + LAT + D + K+W + NF + Sbjct: 392 SGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTL 430 Score = 37.4 bits (85), Expect = 0.008, Method: Compositional matrix adjust. Identities = 37/192 (19%), Positives = 74/192 (38%), Gaps = 4/192 (2%) Query: 10 SDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMI-AAAGYQHIRMY 68 SD + T G D V + S T++ +V ++ P + ++ +A+ IR++ Sbjct: 232 SDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIW 291 Query: 69 DLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVN 128 + N + + + + H G ++ + +D D+++ + + + + Sbjct: 292 SVP--NASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETS 349 Query: 129 A-PINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAA 187 + C HP+ G I IWDLK N P ITS + Y+A Sbjct: 350 GCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLAT 409 Query: 188 VNSTGNCYVWNL 199 + +W+L Sbjct: 410 AADDSSVKLWDL 421 Score = 30.8 bits (68), Expect = 0.82, Method: Compositional matrix adjust. Identities = 25/112 (22%), Positives = 46/112 (41%), Gaps = 15/112 (13%) Query: 199 LTGG------IGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNF 252 LTGG + D+ ++ I T + HT+ F P L+ + S D T +IW N Sbjct: 238 LTGGADKNVVVFDKSSEQILAT-LKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNA 296 Query: 253 SLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEI 304 S + + + + G + Y++++S D ++TG + Sbjct: 297 SCVQVV--------RAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRV 340 >5I2T-A nrPDB Length = 742 Score = 49.3 bits (116), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 59/251 (23%), Positives = 97/251 (38%), Gaps = 34/251 (13%) Query: 87 NIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVG 146 + V FH R + G R++DL L Q++ P+N V ++ L G Sbjct: 287 KVKCVTFHPATRLLAVGFTSGEFRLYDLPDFTL-IQQLSMGQNPVNTVSVNQTGEWLAFG 345 Query: 147 DQS-GAIHIWDLKTDHNEQLIPEPE---VSITSAHIDPDASYMAAVNSTGNCYVWNLTGG 202 G + +++ ++ E I + + S S PD S + + G VW++T G Sbjct: 346 SSKLGQLLVYEWQS---ESYILKQQGHFDSTNSLAYSPDGSRVVTASEDGKIKVWDITSG 402 Query: 203 IGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIW---RTSNFSLMTELS 259 HT +F+ ++ + S D T + W R NF T Sbjct: 403 F--------CLATFEEHTSSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRYRNFRTFT--- 451 Query: 260 IKSGNPGESSRGWMWGCAFSGDSQYIVTASS-DNL-ARLWCVETGEIKREYGGHQKAVVC 317 + + C S +V A S DN +W V+TG++ GH+ V C Sbjct: 452 --------GTERIQFNCLAVDPSGEVVCAGSLDNFDIHVWSVQTGQLLDALSGHEGPVSC 503 Query: 318 LAFN--DSVLG 326 L+F+ +SVL Sbjct: 504 LSFSQENSVLA 514 Score = 48.5 bits (114), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 44/182 (24%), Positives = 83/182 (45%), Gaps = 16/182 (8%) Query: 27 WQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQ-HIRMYDLNSNNPNPIISYDGVN 85 WQ+ S I + H DS N+L +PD S + A I+++D+ S + +++ Sbjct: 357 WQSESYILKQQ-GHFDS-TNSLAYSPDGSRVVTASEDGKIKVWDITSGFC--LATFEEHT 412 Query: 86 KNIASVGFHEDGRWMYTGGEDCTARIWDL-RSRNLQC----QRIFQVNAPINCVCLHPNQ 140 ++ +V F + G+ M++ D T R WDL R RN + +RI NC+ + P+ Sbjct: 413 SSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRYRNFRTFTGTERI-----QFNCLAVDPSG 467 Query: 141 AELIVGDQSGA-IHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNL 199 + G IH+W ++T + E ++ + S +A+ + +W++ Sbjct: 468 EVVCAGSLDNFDIHVWSVQTGQLLDALSGHEGPVSCLSFSQENSVLASASWDKTIRIWSI 527 Query: 200 TG 201 G Sbjct: 528 FG 529 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 66/338 (19%), Positives = 124/338 (36%), Gaps = 82/338 (24%) Query: 36 RTVQHQ---DSQVNALEVTPDRSMIAAAGYQHIRMY---DLNSNNP-NPIISYD---GVN 85 R V H + +A++ +PD + A A + ++++ D+N + P + + G Sbjct: 112 RNVLHHFNFKEKCSAVKFSPDGRLFALASGRFLQIWKTPDVNKDRQFAPFVRHRVHAGHF 171 Query: 86 KNIASVGFHEDGRWMYTGGEDCTARIW--DLRSRNLQCQRIFQVNAPINCVCLHPNQAEL 143 ++I S+ + +D R++ T +D +A+IW D +NL + +Q ++ Sbjct: 172 QDITSLTWSQDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGAFFSHDQEKI 231 Query: 144 IVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGI 203 + GA+ +W+ ++ E E +D Y W +T Sbjct: 232 YTVSKDGAVFVWEFTKRPSDDDDNESEDDDKQEEVDISK------------YSWRIT--- 276 Query: 204 GDEVTQLIPKTKIPAHTRYALQCR-----FSPDSTLLATCSADQTCKIWRTSNFSLMTEL 258 H YA Q + F P + LLA +++ +F+L+ +L Sbjct: 277 -------------KKHFFYANQAKVKCVTFHPATRLLAVGFTSGEFRLYDLPDFTLIQQL 323 Query: 259 SIKSGNP---------------GESSRG----WMW-----------------GCAFSGDS 282 S+ NP G S G + W A+S D Sbjct: 324 SMGQ-NPVNTVSVNQTGEWLAFGSSKLGQLLVYEWQSESYILKQQGHFDSTNSLAYSPDG 382 Query: 283 QYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAF 320 +VTAS D ++W + +G + H +V + F Sbjct: 383 SRVVTASEDGKIKVWDITSGFCLATFEEHTSSVTAVQF 420 Score = 38.9 bits (89), Expect = 0.003, Method: Compositional matrix adjust. Identities = 37/183 (20%), Positives = 77/183 (42%), Gaps = 32/183 (17%) Query: 152 IHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLI 211 + ++DL + + E +I + ++ + + +++ G + N Sbjct: 62 VSVFDLINNKSFTFEYEHRKNIAAIDLNKQGTLLISIDEDGRAILVNFKA---------- 111 Query: 212 PKTKIPAHTRYALQC---RFSPDSTLLATCSADQTCKIWRTSN------FSLMTELSIKS 262 + H + +C +FSPD L A S + +IW+T + F+ + + Sbjct: 112 --RNVLHHFNFKEKCSAVKFSPDGRLFALASG-RFLQIWKTPDVNKDRQFAPFVRHRVHA 168 Query: 263 GNPGE-SSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGE---IKREYGGHQKAVVCL 318 G+ + +S W S DS++I+T S D A++W V++ E + GH+ V+ Sbjct: 169 GHFQDITSLTW------SQDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGA 222 Query: 319 AFN 321 F+ Sbjct: 223 FFS 225 Score = 37.7 bits (86), Expect = 0.007, Method: Compositional matrix adjust. Identities = 38/203 (18%), Positives = 78/203 (38%), Gaps = 20/203 (9%) Query: 54 RSMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWD 113 + +++ G + ++DL NN + Y+ KNIA++ ++ G + + ED A + + Sbjct: 52 KQLLSPVG-NRVSVFDL-INNKSFTFEYEH-RKNIAAIDLNKQGTLLISIDEDGRAILVN 108 Query: 114 LRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDL-KTDHNEQLIPEPEVS 172 ++RN+ F + V P+ L + IW + + Q P Sbjct: 109 FKARNVLHH--FNFKEKCSAVKFSPD-GRLFALASGRFLQIWKTPDVNKDRQFAPFVRHR 165 Query: 173 ITSAHID--------PDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYAL 224 + + H D+ ++ + + +W++ D + + T H Y + Sbjct: 166 VHAGHFQDITSLTWSQDSRFILTTSKDLSAKIWSV-----DSEEKNLAATTFNGHRDYVM 220 Query: 225 QCRFSPDSTLLATCSADQTCKIW 247 FS D + T S D +W Sbjct: 221 GAFFSHDQEKIYTVSKDGAVFVW 243 Score = 34.7 bits (78), Expect = 0.065, Method: Compositional matrix adjust. Identities = 50/252 (19%), Positives = 91/252 (36%), Gaps = 32/252 (12%) Query: 57 IAAAGYQ--HIRMYDLNSNNPN-PIISYDGVNKN-IASVGFHEDGRWMYTGGEDCTARI- 111 + A G+ R+YDL P+ +I + +N + +V ++ G W+ G + Sbjct: 299 LLAVGFTSGEFRLYDL----PDFTLIQQLSMGQNPVNTVSVNQTGEWLAFGSSKLGQLLV 354 Query: 112 --WDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEP 169 W S L+ Q F N + P+ + ++ + G I +WD+ + E Sbjct: 355 YEWQSESYILKQQGHFD---STNSLAYSPDGSRVVTASEDGKIKVWDITSGFCLATFEEH 411 Query: 170 EVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQC-RF 228 S+T+ M + + G W+L + R C Sbjct: 412 TSSVTAVQFAKRGQVMFSSSLDGTVRAWDL--------IRYRNFRTFTGTERIQFNCLAV 463 Query: 229 SPDSTLLATCSADQ-TCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVT 287 P ++ S D +W L+ L SG+ G S +FS ++ + + Sbjct: 464 DPSGEVVCAGSLDNFDIHVWSVQTGQLLDAL---SGHEGPVS-----CLSFSQENSVLAS 515 Query: 288 ASSDNLARLWCV 299 AS D R+W + Sbjct: 516 ASWDKTIRIWSI 527 >5WLC-LO nrPDB Length = 923 Score = 49.3 bits (116), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 59/247 (23%), Positives = 96/247 (38%), Gaps = 34/247 (13%) Query: 91 VGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQS- 149 V FH R + G R++DL L Q++ P+N V ++ L G Sbjct: 266 VTFHPATRLLAVGFTSGEFRLYDLPDFTL-IQQLSMGQNPVNTVSVNQTGEWLAFGSSKL 324 Query: 150 GAIHIWDLKTDHNEQLIPEPE---VSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDE 206 G + +++ ++ E I + + S S PD S + + G VW++T G Sbjct: 325 GQLLVYEWQS---ESYILKQQGHFDSTNSLAYSPDGSRVVTASEDGKIKVWDITSGFC-- 379 Query: 207 VTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIW---RTSNFSLMTELSIKSG 263 HT +F+ ++ + S D T + W R NF T Sbjct: 380 ------LATFEEHTSSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRYRNFRTFT------- 426 Query: 264 NPGESSRGWMWGCAFSGDSQYIVTASS-DNL-ARLWCVETGEIKREYGGHQKAVVCLAFN 321 + + C S +V A S DN +W V+TG++ GH+ V CL+F+ Sbjct: 427 ----GTERIQFNCLAVDPSGEVVCAGSLDNFDIHVWSVQTGQLLDALSGHEGPVSCLSFS 482 Query: 322 --DSVLG 326 +SVL Sbjct: 483 QENSVLA 489 Score = 47.8 bits (112), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 44/182 (24%), Positives = 83/182 (45%), Gaps = 16/182 (8%) Query: 27 WQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQ-HIRMYDLNSNNPNPIISYDGVN 85 WQ+ S I + H DS N+L +PD S + A I+++D+ S + +++ Sbjct: 332 WQSESYILKQQ-GHFDS-TNSLAYSPDGSRVVTASEDGKIKVWDITSGFC--LATFEEHT 387 Query: 86 KNIASVGFHEDGRWMYTGGEDCTARIWDL-RSRNLQC----QRIFQVNAPINCVCLHPNQ 140 ++ +V F + G+ M++ D T R WDL R RN + +RI NC+ + P+ Sbjct: 388 SSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRYRNFRTFTGTERI-----QFNCLAVDPSG 442 Query: 141 AELIVGDQSGA-IHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNL 199 + G IH+W ++T + E ++ + S +A+ + +W++ Sbjct: 443 EVVCAGSLDNFDIHVWSVQTGQLLDALSGHEGPVSCLSFSQENSVLASASWDKTIRIWSI 502 Query: 200 TG 201 G Sbjct: 503 FG 504 Score = 43.5 bits (101), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 66/338 (19%), Positives = 124/338 (36%), Gaps = 82/338 (24%) Query: 36 RTVQHQ---DSQVNALEVTPDRSMIAAAGYQHIRMY---DLNSNNP-NPIISYD---GVN 85 R V H + +A++ +PD + A A + ++++ D+N + P + + G Sbjct: 87 RNVLHHFNFKEKCSAVKFSPDGRLFALASGRFLQIWKTPDVNKDRQFAPFVRHRVHAGHF 146 Query: 86 KNIASVGFHEDGRWMYTGGEDCTARIW--DLRSRNLQCQRIFQVNAPINCVCLHPNQAEL 143 ++I S+ + +D R++ T +D +A+IW D +NL + +Q ++ Sbjct: 147 QDITSLTWSQDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGAFFSHDQEKI 206 Query: 144 IVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGI 203 + GA+ +W+ ++ E E +D Y W +T Sbjct: 207 YTVSKDGAVFVWEFTKRPSDDDDNESEDDDKQEEVDISK------------YSWRIT--- 251 Query: 204 GDEVTQLIPKTKIPAHTRYALQCR-----FSPDSTLLATCSADQTCKIWRTSNFSLMTEL 258 H YA Q + F P + LLA +++ +F+L+ +L Sbjct: 252 -------------KKHFFYANQAKVKCVTFHPATRLLAVGFTSGEFRLYDLPDFTLIQQL 298 Query: 259 SIKSGNP---------------GESSRG----WMW-----------------GCAFSGDS 282 S+ NP G S G + W A+S D Sbjct: 299 SM-GQNPVNTVSVNQTGEWLAFGSSKLGQLLVYEWQSESYILKQQGHFDSTNSLAYSPDG 357 Query: 283 QYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAF 320 +VTAS D ++W + +G + H +V + F Sbjct: 358 SRVVTASEDGKIKVWDITSGFCLATFEEHTSSVTAVQF 395 Score = 38.9 bits (89), Expect = 0.003, Method: Compositional matrix adjust. Identities = 37/183 (20%), Positives = 77/183 (42%), Gaps = 32/183 (17%) Query: 152 IHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLI 211 + ++DL + + E +I + ++ + + +++ G + N Sbjct: 37 VSVFDLINNKSFTFEYEHRKNIAAIDLNKQGTLLISIDEDGRAILVNFKA---------- 86 Query: 212 PKTKIPAHTRYALQC---RFSPDSTLLATCSADQTCKIWRTSN------FSLMTELSIKS 262 + H + +C +FSPD L A S + +IW+T + F+ + + Sbjct: 87 --RNVLHHFNFKEKCSAVKFSPDGRLFALASG-RFLQIWKTPDVNKDRQFAPFVRHRVHA 143 Query: 263 GNPGE-SSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGE---IKREYGGHQKAVVCL 318 G+ + +S W S DS++I+T S D A++W V++ E + GH+ V+ Sbjct: 144 GHFQDITSLTW------SQDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGA 197 Query: 319 AFN 321 F+ Sbjct: 198 FFS 200 Score = 37.4 bits (85), Expect = 0.010, Method: Compositional matrix adjust. Identities = 38/203 (18%), Positives = 78/203 (38%), Gaps = 20/203 (9%) Query: 54 RSMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWD 113 + +++ G + ++DL NN + Y+ KNIA++ ++ G + + ED A + + Sbjct: 27 KQLLSPVG-NRVSVFDL-INNKSFTFEYEH-RKNIAAIDLNKQGTLLISIDEDGRAILVN 83 Query: 114 LRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDL-KTDHNEQLIPEPEVS 172 ++RN+ F + V P+ L + IW + + Q P Sbjct: 84 FKARNVLHH--FNFKEKCSAVKFSPD-GRLFALASGRFLQIWKTPDVNKDRQFAPFVRHR 140 Query: 173 ITSAHID--------PDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYAL 224 + + H D+ ++ + + +W++ D + + T H Y + Sbjct: 141 VHAGHFQDITSLTWSQDSRFILTTSKDLSAKIWSV-----DSEEKNLAATTFNGHRDYVM 195 Query: 225 QCRFSPDSTLLATCSADQTCKIW 247 FS D + T S D +W Sbjct: 196 GAFFSHDQEKIYTVSKDGAVFVW 218 Score = 33.9 bits (76), Expect = 0.11, Method: Compositional matrix adjust. Identities = 50/252 (19%), Positives = 91/252 (36%), Gaps = 32/252 (12%) Query: 57 IAAAGYQ--HIRMYDLNSNNPN-PIISYDGVNKN-IASVGFHEDGRWMYTGGEDCTARI- 111 + A G+ R+YDL P+ +I + +N + +V ++ G W+ G + Sbjct: 274 LLAVGFTSGEFRLYDL----PDFTLIQQLSMGQNPVNTVSVNQTGEWLAFGSSKLGQLLV 329 Query: 112 --WDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEP 169 W S L+ Q F N + P+ + ++ + G I +WD+ + E Sbjct: 330 YEWQSESYILKQQGHFD---STNSLAYSPDGSRVVTASEDGKIKVWDITSGFCLATFEEH 386 Query: 170 EVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQC-RF 228 S+T+ M + + G W+L + R C Sbjct: 387 TSSVTAVQFAKRGQVMFSSSLDGTVRAWDL--------IRYRNFRTFTGTERIQFNCLAV 438 Query: 229 SPDSTLLATCSADQ-TCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVT 287 P ++ S D +W L+ L SG+ G S +FS ++ + + Sbjct: 439 DPSGEVVCAGSLDNFDIHVWSVQTGQLLDAL---SGHEGPVS-----CLSFSQENSVLAS 490 Query: 288 ASSDNLARLWCV 299 AS D R+W + Sbjct: 491 ASWDKTIRIWSI 502 >5NZU-C nrPDB Length = 905 Score = 49.3 bits (116), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 35/152 (23%), Positives = 73/152 (48%), Gaps = 11/152 (7%) Query: 10 SDPVILATAGYDHTVRFWQ-AHSGICTRTVQHQDSQVNALEVTP-DRSMIAAAGYQH-IR 66 + P IL T+ D ++ W C++ + V + + P D + A+A I+ Sbjct: 110 TQPFIL-TSSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIK 168 Query: 67 MYDLNSNNPNPIISYDGVNKNIASVGFHE--DGRWMYTGGEDCTARIWDLRSRNLQCQRI 124 ++ L S++PN + +G K + + ++ D ++ +G +D +IWD +++ C + Sbjct: 169 VWQLGSSSPN--FTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKT--CVQT 224 Query: 125 FQVNAP-INCVCLHPNQAELIVGDQSGAIHIW 155 + +A ++C HP +I G + G + IW Sbjct: 225 LEGHAQNVSCASFHPELPIIITGSEDGTVRIW 256 Score = 43.5 bits (101), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 47/242 (19%), Positives = 96/242 (39%), Gaps = 29/242 (11%) Query: 88 IASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQV-NAPINCVCLHPNQAELIVG 146 + SV H WM + + +W+ ++ L + F+V + P+ + ++ G Sbjct: 18 VKSVDLHPTEPWMLASLYNGSVCVWNHETQTLV--KTFEVCDLPVRAAKFVARKNWVVTG 75 Query: 147 DQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDE 206 I +++ T + I + P ++ + +W+ Sbjct: 76 ADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKKWS-- 133 Query: 207 VTQLIPKTKIPAHTRYALQCRFSP-DSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNP 265 +Q+ HT Y +Q +P D+ A+ S D+T K+W+ + S +++ Sbjct: 134 CSQVFE-----GHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSS--PNFTLEGHEK 186 Query: 266 GESSRGWMWGCAFSGDSQYIVTASSDNLARLW------CVETGEIKREYGGHQKAVVCLA 319 G + + G GD Y+++ + D L ++W CV+T E GH + V C + Sbjct: 187 GVNCIDYYSG----GDKPYLISGADDRLVKIWDYQNKTCVQTLE------GHAQNVSCAS 236 Query: 320 FN 321 F+ Sbjct: 237 FH 238 Score = 42.0 bits (97), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 28/109 (25%), Positives = 54/109 (49%), Gaps = 5/109 (4%) Query: 15 LATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTP--DRS-MIAAAGYQHIRMYDLN 71 A+A D T++ WQ S T++ + VN ++ D+ +I+ A + ++++D Sbjct: 158 FASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQ 217 Query: 72 SNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQ 120 N + + +G +N++ FH + + TG ED T RIW + L+ Sbjct: 218 --NKTCVQTLEGHAQNVSCASFHPELPIIITGSEDGTVRIWHSSTYRLE 264 Score = 38.5 bits (88), Expect = 0.004, Method: Compositional matrix adjust. Identities = 49/239 (20%), Positives = 90/239 (37%), Gaps = 27/239 (11%) Query: 88 IASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAP-INCVCLHPNQAELIVG 146 + + F W+ TG +D R+++ + L+ +F+ ++ I C+ +HP Q ++ Sbjct: 60 VRAAKFVARKNWVVTGADDMQIRVFNYNT--LERVHMFEAHSDYIRCIAVHPTQPFILTS 117 Query: 147 DQSGAIHIWDLKTDHN-EQLIPEPEVSITSAHIDP-DASYMAAVNSTGNCYVWNLTGGIG 204 I +WD + Q+ + I+P D + A+ + VW L Sbjct: 118 SDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSS- 176 Query: 205 DEVTQLIPKTKIPAHTRYALQC---RFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIK 261 P + H + + C D L + + D+ KIW N + + L Sbjct: 177 -------PNFTLEGHEK-GVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGH 228 Query: 262 SGNPGESSRGWMWGCA-FSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLA 319 + N CA F + I+T S D R+W T ++ + V C+A Sbjct: 229 AQNVS---------CASFHPELPIIITGSEDGTVRIWHSSTYRLESTLNYGMERVWCVA 278 Score = 35.0 bits (79), Expect = 0.049, Method: Compositional matrix adjust. Identities = 44/255 (17%), Positives = 101/255 (39%), Gaps = 17/255 (6%) Query: 10 SDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRS-MIAAAGYQHIRMY 68 ++P +LA+ Y+ +V W + +T + D V A + ++ ++ A IR++ Sbjct: 26 TEPWMLASL-YNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVARKNWVVTGADDMQIRVF 84 Query: 69 DLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVN 128 N N + ++ + I + H ++ T +D ++WD + C ++F+ + Sbjct: 85 --NYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDW-DKKWSCSQVFEGH 141 Query: 129 AP-INCVCLHP-NQAELIVGDQSGAIHIWDLKTDHNEQLIP--EPEVSITSAHIDPDASY 184 + + ++P + + I +W L + + E V+ + D Y Sbjct: 142 THYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYSGGDKPY 201 Query: 185 MAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTC 244 + + +W+ + + H + F P+ ++ T S D T Sbjct: 202 LISGADDRLVKIWDYQNKTCVQT--------LEGHAQNVSCASFHPELPIIITGSEDGTV 253 Query: 245 KIWRTSNFSLMTELS 259 +IW +S + L + L+ Sbjct: 254 RIWHSSTYRLESTLN 268 >3DM0-A nrPDB Length = 694 Score = 48.5 bits (114), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 41/197 (20%), Positives = 80/197 (40%), Gaps = 21/197 (10%) Query: 131 INCVCLHPNQAELIV-GDQSGAIHIWDLKTDHNEQLIPEPEVS-----ITSAHIDPDASY 184 + + + A++IV + +I +W L D + + ++ + + D + Sbjct: 385 VTAIATPIDNADIIVSASRDKSIILWKLTKDDKAYGVAQRRLTGHSHFVEDVVLSSDGQF 444 Query: 185 MAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTC 244 + + G +W+L G+ + HT+ L FS D+ + + S D+T Sbjct: 445 ALSGSWDGELRLWDLAAGVSTR--------RFVGHTKDVLSVAFSLDNRQIVSASRDRTI 496 Query: 245 KIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDS--QYIVTASSDNLARLWCVETG 302 K+W T + E GE R W+ FS ++ IV+AS D ++W + Sbjct: 497 KLWNT-----LGECKYTISEGGEGHRDWVSCVRFSPNTLQPTIVSASWDKTVKVWNLSNC 551 Query: 303 EIKREYGGHQKAVVCLA 319 +++ GH V +A Sbjct: 552 KLRSTLAGHTGYVSTVA 568 Score = 47.8 bits (112), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 61/311 (19%), Positives = 124/311 (39%), Gaps = 41/311 (13%) Query: 14 ILATAGYDHTVRFWQAHS-----GICTRTVQHQDSQVNALEVTPDRSMIAAAGYQ-HIRM 67 I+ +A D ++ W+ G+ R + V + ++ D + + +R+ Sbjct: 397 IIVSASRDKSIILWKLTKDDKAYGVAQRRLTGHSHFVEDVVLSSDGQFALSGSWDGELRL 456 Query: 68 YDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQV 127 +DL + + G K++ SV F D R + + D T ++W+ +C+ Sbjct: 457 WDLAAGVSTR--RFVGHTKDVLSVAFSLDNRQIVSASRDRTIKLWNTLG---ECKYTISE 511 Query: 128 NAP-----INCVCLHPN--QAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDP 180 ++CV PN Q ++ + +W+L + +++ + P Sbjct: 512 GGEGHRDWVSCVRFSPNTLQPTIVSASWDKTVKVWNLSNCKLRSTLAGHTGYVSTVAVSP 571 Query: 181 DASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSA 240 D S A+ G +W+L G ++ L + I A C FSP+ L C+A Sbjct: 572 DGSLCASGGKDGVVLLWDLAE--GKKLYSLEANSVIHA------LC-FSPNRYWL--CAA 620 Query: 241 -DQTCKIWRTSNFSLMTELSI-------KSGN--PGESSRGWMW--GCAFSGDSQYIVTA 288 + KIW + S++ +L + K+ N P + R ++ +S D + + Sbjct: 621 TEHGIKIWDLESKSIVEDLKVDLKAEAEKADNSGPAATKRKVIYCTSLNWSADGSTLFSG 680 Query: 289 SSDNLARLWCV 299 +D + R+W + Sbjct: 681 YTDGVIRVWGI 691 Score = 35.0 bits (79), Expect = 0.042, Method: Compositional matrix adjust. Identities = 35/158 (22%), Positives = 62/158 (39%), Gaps = 53/158 (33%) Query: 4 SPGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQ 63 SP T+ P I+ +A +D TV+ W + T+ V+ + V+PD S+ A Sbjct: 526 SPNTL--QPTIV-SASWDKTVKVWNLSNCKLRSTLAGHTGYVSTVAVSPDGSLCA----- 577 Query: 64 HIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQR 123 +GG+D +WDL + ++ Sbjct: 578 --------------------------------------SGGKDGVVLLWDLA----EGKK 595 Query: 124 IF--QVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKT 159 ++ + N+ I+ +C PN+ L + G I IWDL++ Sbjct: 596 LYSLEANSVIHALCFSPNRYWLCAATEHG-IKIWDLES 632 Score = 35.0 bits (79), Expect = 0.044, Method: Compositional matrix adjust. Identities = 16/46 (34%), Positives = 24/46 (52%) Query: 276 CAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFN 321 S D Q+ ++ S D RLW + G R + GH K V+ +AF+ Sbjct: 436 VVLSSDGQFALSGSWDGELRLWDLAAGVSTRRFVGHTKDVLSVAFS 481 Score = 32.0 bits (71), Expect = 0.37, Method: Compositional matrix adjust. Identities = 27/124 (21%), Positives = 52/124 (41%), Gaps = 18/124 (14%) Query: 8 VGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRM 67 V D + A+ G D V W G +++ +S ++AL +P+R + AA I++ Sbjct: 569 VSPDGSLCASGGKDGVVLLWDLAEGKKLYSLE-ANSVIHALCFSPNRYWLCAATEHGIKI 627 Query: 68 YDLNSNNPNPIISYD--------------GVNKNI---ASVGFHEDGRWMYTGGEDCTAR 110 +DL S + + D + + S+ + DG +++G D R Sbjct: 628 WDLESKSIVEDLKVDLKAEAEKADNSGPAATKRKVIYCTSLNWSADGSTLFSGYTDGVIR 687 Query: 111 IWDL 114 +W + Sbjct: 688 VWGI 691 >6J6H-n nrPDB Length = 455 Score = 48.5 bits (114), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 60/259 (23%), Positives = 104/259 (40%), Gaps = 23/259 (8%) Query: 47 ALEVTPDRS-MIAAAGYQH-IRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGG 104 AL+ P +I + G H I+++D ++ + + G NK I ++ F ED + + Sbjct: 167 ALKFLPKTGHLILSGGNDHTIKIWDF-YHDYECLRDFQGHNKPIKALRFTEDCQSFLSSS 225 Query: 105 EDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQ 164 D + +IWD + ++ R+ + P + N E IVG + I +D + N+ Sbjct: 226 FDRSVKIWDTETGKVKT-RLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQG 284 Query: 165 LIPEPE---VSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTR 221 L+ + SI + PD S + + +W E +P +I + Sbjct: 285 LVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIW--------ENQINVPIKQISDTAQ 336 Query: 222 YALQ-CRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSI--KSGNPGESSRGWMWGCAF 278 +++ P S D R +FSL + K G SS G+ AF Sbjct: 337 HSMPFLNVHPSQNYFCAQSMDN-----RIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAF 391 Query: 279 SGDSQYIVTASSDNLARLW 297 SGD +YI + S + W Sbjct: 392 SGDGRYICSGDSKSRLFTW 410 Score = 42.0 bits (97), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 54/270 (20%), Positives = 107/270 (39%), Gaps = 36/270 (13%) Query: 14 ILATAGYDHTVRFWQ-AHSGICTRTVQHQDSQVNALEVTPD-RSMIAAAGYQHIRMYDLN 71 ++ + G DHT++ W H C R Q + + AL T D +S ++++ + ++++D Sbjct: 177 LILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTE 236 Query: 72 SNNPNPIISYDGVNKNIAS--VGFHEDGRWMYTGGEDCTARIWDLR-SRNLQCQRIFQVN 128 + + + ++ S HE G + +D R S N + + + Sbjct: 237 TGKVKTRLHLNSTPADVESRPTNPHE----FIVGLSNSKILHYDDRVSENQGLVQTYDHH 292 Query: 129 -APINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAH------IDPD 181 + I + P+ ++ I + + IW+ N+ +P ++S T+ H + P Sbjct: 293 LSSILALKYFPDGSKFISSSEDKTVRIWE-----NQINVPIKQISDTAQHSMPFLNVHPS 347 Query: 182 ASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTR--YALQCRFSPDSTLLATCS 239 +Y A + Y ++L + PK H+ Y + FS D + CS Sbjct: 348 QNYFCAQSMDNRIYSFSLKPKY-----KRHPKKIFKGHSSAGYGISLAFSGDGRYI--CS 400 Query: 240 ADQTCKI----WRTSNFSLMTELSIKSGNP 265 D ++ W TS L+ + I P Sbjct: 401 GDSKSRLFTWDWNTSR--LLNNIKIPGNKP 428 Score = 40.8 bits (94), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 49/245 (20%), Positives = 90/245 (36%), Gaps = 38/245 (15%) Query: 15 LATAGYDHTVRFWQAHSGICTRTVQHQDS---QVNALEVTPDRSMIAAAGYQHIRMYDLN 71 ++ +D +V+ W +G +T H +S V + P ++ + + + D Sbjct: 221 FLSSSFDRSVKIWDTETGKV-KTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRV 279 Query: 72 SNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPI 131 S N + +YD +I ++ + DG + ED T RIW+ Q+N PI Sbjct: 280 SENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWEN-----------QINVPI 328 Query: 132 NCVC-----------LHPNQAELIVGDQSGAIHIWDLKTDHNE--QLIPEPEVSI---TS 175 + +HP+Q I+ + LK + + I + S S Sbjct: 329 KQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGIS 388 Query: 176 AHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLL 235 D Y+ + +S + W+ ++L+ KIP + Q + P T Sbjct: 389 LAFSGDGRYICSGDSKSRLFTWDWN------TSRLLNNIKIPG-NKPITQVDWHPQETSK 441 Query: 236 ATCSA 240 CS Sbjct: 442 VICSG 446 Score = 30.0 bits (66), Expect = 1.3, Method: Compositional matrix adjust. Identities = 25/100 (25%), Positives = 44/100 (44%), Gaps = 13/100 (13%) Query: 211 IPKTKI---PAHTRYALQCRFSPDS-TLLATCSADQTCKIWR-TSNFSLMTELSIKSGNP 265 +PK I P H +F P + L+ + D T KIW ++ + + P Sbjct: 150 LPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQ-GHNKP 208 Query: 266 GESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIK 305 ++ R F+ D Q +++S D ++W ETG++K Sbjct: 209 IKALR-------FTEDCQSFLSSSFDRSVKIWDTETGKVK 241 >4V6W-Ag nrPDB Length = 318 Score = 48.1 bits (113), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 63/315 (20%), Positives = 123/315 (39%), Gaps = 38/315 (12%) Query: 3 TSPGTVGSDPVILATAGYDHTVRFWQ------AHSGICTRTVQHQDSQVNALEVTPDRSM 56 T T DP + +A D T+ W+ + G + + ++ + ++ D + Sbjct: 19 TQIATNPKDPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRLYGHSHFISDVVLSSDGNY 78 Query: 57 IAAAGY-QHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLR 115 + + Q +R++DL + ++G K++ SV F D R + +G D T ++W+ Sbjct: 79 ALSGSWDQTLRLWDLAAGKTTR--RFEGHTKDVLSVAFSADNRQIVSGSRDKTIKLWNTL 136 Query: 116 SRNLQCQRIFQVNAP---INCVCLHPNQAELIVGD--QSGAIHIWD-----LKTDHNEQL 165 + +C+ Q + ++CV PN + I+ + +W+ LK +H+ Sbjct: 137 A---ECKFTIQEDGHTDWVSCVRFSPNHSNPIIVSCGWDRTVKVWNLANCKLKNNHHGH- 192 Query: 166 IPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQ 225 + + + PD S + +W+L G + H Sbjct: 193 ----NGYLNTVTVSPDGSLCTSGGKDSKALLWDLNDGKNLYTLE---------HNDIINA 239 Query: 226 CRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNP-GESSRGWMWGCAFSGDSQY 284 FSP+ L + KIW + + EL + +P ++ + A+S D Q Sbjct: 240 LCFSPNRYWLCVAYG-PSIKIWDLACKKTVEELRPEVVSPTSKADQPQCLSLAWSTDGQT 298 Query: 285 IVTASSDNLARLWCV 299 + SDN R+W V Sbjct: 299 LFAGYSDNTIRVWQV 313 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 31/120 (25%), Positives = 52/120 (43%), Gaps = 11/120 (9%) Query: 206 EVTQLIPKTKIPAHTRYALQCRFSP-DSTLLATCSADQTCKIWRTSNFSLMTELSIKSGN 264 E QL + + H + Q +P D + + S D+T +W+ L + G Sbjct: 3 ETLQL--RGTLIGHNGWVTQIATNPKDPDTIISASRDKTLIVWK-----LTRDEDTNYGY 55 Query: 265 PGESSRG---WMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFN 321 P + G ++ S D Y ++ S D RLW + G+ R + GH K V+ +AF+ Sbjct: 56 PQKRLYGHSHFISDVVLSSDGNYALSGSWDQTLRLWDLAAGKTTRRFEGHTKDVLSVAFS 115 Score = 34.7 bits (78), Expect = 0.054, Method: Compositional matrix adjust. Identities = 38/193 (19%), Positives = 77/193 (39%), Gaps = 24/193 (12%) Query: 128 NAPINCVCLHPNQAELIV-GDQSGAIHIWDLKTDHNEQL-IPEPEVS-----ITSAHIDP 180 N + + +P + I+ + + +W L D + P+ + I+ + Sbjct: 15 NGWVTQIATNPKDPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRLYGHSHFISDVVLSS 74 Query: 181 DASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSA 240 D +Y + + +W+L G + T+ + HT+ L FS D+ + + S Sbjct: 75 DGNYALSGSWDQTLRLWDLAAG---KTTR-----RFEGHTKDVLSVAFSADNRQIVSGSR 126 Query: 241 DQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGD--SQYIVTASSDNLARLWC 298 D+T K+W T + E G + W+ FS + + IV+ D ++W Sbjct: 127 DKTIKLWNT-----LAECKFTIQEDGHTD--WVSCVRFSPNHSNPIIVSCGWDRTVKVWN 179 Query: 299 VETGEIKREYGGH 311 + ++K + GH Sbjct: 180 LANCKLKNNHHGH 192 >5A9Q-0 nrPDB Length = 380 Score = 47.8 bits (112), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 44/164 (26%), Positives = 75/164 (45%), Gaps = 6/164 (3%) Query: 6 GTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQ-VNALEV--TPDRSMIAAAGY 62 G V ++P I+ T G D + ++A RT+ + DS ++A+ TP+ + + G Sbjct: 136 GVVCNNPEIV-TVGEDGRINLFRADHKEAVRTIDNADSSTLHAVTFLRTPEILTVNSIGQ 194 Query: 63 QHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMY-TGGEDCTARIWDLRSRNLQC 121 I + N P+ I+S G + V H + + + TGG+D IWD+R + Sbjct: 195 LKIWDFRQQGNEPSQILSLTGDRVPLHCVDRHPNQQHVVATGGQDGMLSIWDVRQGTMPV 254 Query: 122 QRIFQVNAPINCVCLHPNQAE-LIVGDQSGAIHIWDLKTDHNEQ 164 + A + V HP+ E L + G++ WD TD E+ Sbjct: 255 SLLKAHEAEMWEVHFHPSNPEHLFTCSEDGSLWHWDASTDVPEK 298 >3JB9-g nrPDB Length = 558 Score = 47.8 bits (112), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 53/245 (21%), Positives = 98/245 (40%), Gaps = 24/245 (9%) Query: 15 LATAGYDHTVRFWQAHSGICTRTVQHQDSQVN--ALEVTPDRSMIAAAGYQHIRMYDLNS 72 + +D T++ W G C + D N +V PD+ AG R+ + Sbjct: 325 FLSTSFDKTIKLWDTELGKCLNCF-NSDRLTNCVKFQVDPDKPNEFLAGTADKRILQFDI 383 Query: 73 NNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPIN 132 +P+ + +YD I S+ F E+G+ T +D + R W+ + F + ++ Sbjct: 384 RSPDIVQAYDHHLGGINSITFLENGKRFVTTSDDSSMRFWEYGT---PVPIKFVADIAMH 440 Query: 133 C---VCLHPNQAELIVGDQSGAIHIWDLKTDHNE---QLIPEPEVSITSAHI--DPDASY 184 V L PN + I+++ + + ++ S S + PD + Sbjct: 441 SMPRVALRPNGKSIACQSLDNCIYVYSAYEKYRQNKKKVFKGYSCSGYSLEVGFSPDGRF 500 Query: 185 MAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDST-LLATCS-ADQ 242 + + +S+GN W+ + +L+ K+PAH+ F P T +AT S D Sbjct: 501 VFSGDSSGNACFWDW------KTCKLM--AKLPAHSGPVQSMAFHPQETSKVATSSIVDG 552 Query: 243 TCKIW 247 + K W Sbjct: 553 SIKYW 557 Score = 37.4 bits (85), Expect = 0.009, Method: Compositional matrix adjust. Identities = 57/283 (20%), Positives = 104/283 (36%), Gaps = 36/283 (12%) Query: 42 DSQVNALEVTPDRSMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMY 101 D+Q+ EV DRS++ ++ G + I + F +DGR Sbjct: 288 DNQIKIWEVYHDRSLLR---------------------TFQGHARPIRDLSFSQDGRSFL 326 Query: 102 TGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLH--PNQA-ELIVGDQSGAIHIWDLK 158 + D T ++WD + +C F + NCV P++ E + G I +D++ Sbjct: 327 STSFDKTIKLWD--TELGKCLNCFNSDRLTNCVKFQVDPDKPNEFLAGTADKRILQFDIR 384 Query: 159 TDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPA 218 + Q I S + + + W + + I +P Sbjct: 385 SPDIVQAYDHHLGGINSITFLENGKRFVTTSDDSSMRFWEYGTPVPIKFVADIAMHSMP- 443 Query: 219 HTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAF 278 R AL+ P+ +A C + C I+ S + + + K G S G+ F Sbjct: 444 --RVALR----PNGKSIA-CQSLDNC-IYVYSAYEKYRQ-NKKKVFKGYSCSGYSLEVGF 494 Query: 279 SGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFN 321 S D +++ + S A W +T ++ + H V +AF+ Sbjct: 495 SPDGRFVFSGDSSGNACFWDWKTCKLMAKLPAHSGPVQSMAFH 537 Score = 36.6 bits (83), Expect = 0.015, Method: Compositional matrix adjust. Identities = 18/68 (26%), Positives = 32/68 (47%), Gaps = 3/68 (4%) Query: 91 VGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQ-- 148 VGF DGR++++G A WD ++ L ++ + P+ + HP + + Sbjct: 492 VGFSPDGRFVFSGDSSGNACFWDWKTCKLMA-KLPAHSGPVQSMAFHPQETSKVATSSIV 550 Query: 149 SGAIHIWD 156 G+I WD Sbjct: 551 DGSIKYWD 558 >5GAN-H nrPDB Length = 465 Score = 47.4 bits (111), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 30/125 (24%), Positives = 64/125 (51%), Gaps = 4/125 (3%) Query: 42 DSQVNALEVTPDRSMIAAAGYQHI-RMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWM 100 + +++ ++ P I +A + R++D +++ ++ +G +K + S+ F DG + Sbjct: 265 ERRISDVKYHPSGKFIGSASHDMTWRLWDASTHQE--LLLQEGHDKGVFSLSFQCDGSLV 322 Query: 101 YTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTD 160 +GG D + +WD+RS + + + + PI V PN ++ G G I++WD++ Sbjct: 323 CSGGMDSLSMLWDIRSGS-KVMTLAGHSKPIYTVAWSPNGYQVATGGGDGIINVWDIRKR 381 Query: 161 HNEQL 165 QL Sbjct: 382 DEGQL 386 Score = 38.9 bits (89), Expect = 0.003, Method: Compositional matrix adjust. Identities = 23/106 (21%), Positives = 47/106 (44%), Gaps = 8/106 (7%) Query: 216 IPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWG 275 + H R ++ P + + S D T ++W S EL ++ G+ +G ++ Sbjct: 261 LVGHERRISDVKYHPSGKFIGSASHDMTWRLWDASTHQ---ELLLQEGH----DKG-VFS 312 Query: 276 CAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFN 321 +F D + + D+L+ LW + +G GH K + +A++ Sbjct: 313 LSFQCDGSLVCSGGMDSLSMLWDIRSGSKVMTLAGHSKPIYTVAWS 358 >5A9Q-2 nrPDB Length = 326 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 45/191 (23%), Positives = 83/191 (43%), Gaps = 13/191 (6%) Query: 50 VTPDRSMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFH-EDGRWMYTGGEDCT 108 + P +A IR++ + + N +G I + F ++G+ + + +D T Sbjct: 89 LPPVIKFCTSAADMKIRLFTSDLQDKNEYKVLEGHTDFINGLVFDPKEGQEIASVSDDHT 148 Query: 109 ARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQA-ELIVGDQSGAIHIWDLKTDHNEQLIP 167 RIW+L +Q F +++P VC HP + +L+V +++G I +DL + Sbjct: 149 CRIWNLEG--VQTAH-FVLHSPGMSVCWHPEETFKLMVAEKNGTIRFYDLLAQQAILSLE 205 Query: 168 EPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCR 227 +V + SAH ++ + + +W++T P+ K P H A R Sbjct: 206 SEQVPLMSAHWCLKNTFKVGAVAGNDWLIWDIT-------RSSYPQNKRPVHMDRACLFR 258 Query: 228 FSPDS-TLLAT 237 +S S L AT Sbjct: 259 WSTISENLFAT 269 >5Y88-O nrPDB Length = 451 Score = 46.6 bits (109), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 43/200 (21%), Positives = 80/200 (40%), Gaps = 10/200 (5%) Query: 8 VGSDPVI---LATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRS--MIAAAGY 62 V DPV T D T++ W +G T+ V + V+ DR + + + Sbjct: 145 VAIDPVDNEWFITGSNDTTMKVWDLATGKLKTTLAGHVMTVRDVAVS-DRHPYLFSVSED 203 Query: 63 QHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQ 122 + ++ +DL N I Y G + +V H + T G D ++WD+R+R + Sbjct: 204 KTVKCWDLEKNQI--IRDYYGHLSGVRTVSIHPTLDLIATAGRDSVIKLWDMRTR-IPVI 260 Query: 123 RIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDA 182 + PIN V P +++ + +WD+ +++ + S+ + + P Sbjct: 261 TLVGHKGPINQVQCTPVDPQVVSSSTDATVRLWDVVAGKTMKVLTHHKRSVRATALHP-K 319 Query: 183 SYMAAVNSTGNCYVWNLTGG 202 + A T + W L G Sbjct: 320 EFSVASACTDDIRSWGLAEG 339 Score = 41.2 bits (95), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 31/161 (19%), Positives = 72/161 (44%), Gaps = 9/161 (5%) Query: 14 ILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTP-DRSMIAAAGYQHIRMYDLNS 72 ++ATAG D ++ W + I T+ +N ++ TP D +++++ +R++D+ + Sbjct: 238 LIATAGRDSVIKLWDMRTRIPVITLVGHKGPINQVQCTPVDPQVVSSSTDATVRLWDVVA 297 Query: 73 NNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCT--ARIWDLRSRNLQCQRIFQVNAP 130 ++++ +++ + H ++ CT R W L +L + Sbjct: 298 GKTMKVLTHH--KRSVRATALHPKE---FSVASACTDDIRSWGLAEGSLLTNFESEKTGI 352 Query: 131 INCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEV 171 IN + ++ + L G +G + +D K+ H Q + E+ Sbjct: 353 INTLSINQDDV-LFAGGDNGVLSFYDYKSGHKYQSLATREM 392 Score = 37.4 bits (85), Expect = 0.008, Method: Compositional matrix adjust. Identities = 42/194 (21%), Positives = 76/194 (39%), Gaps = 21/194 (10%) Query: 131 INCVCLHPNQAE-LIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVN 189 + CV + P E I G + +WDL T + + +++ + Y+ +V+ Sbjct: 142 VRCVAIDPVDNEWFITGSNDTTMKVWDLATGKLKTTLAGHVMTVRDVAVSDRHPYLFSVS 201 Query: 190 STGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRT 249 W+L E Q+I H P L+AT D K+W Sbjct: 202 EDKTVKCWDL------EKNQII--RDYYGHLSGVRTVSIHPTLDLIATAGRDSVIKLW-- 251 Query: 250 SNFSLMTELSIKS--GNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKRE 307 + T + + + G+ G ++ C D Q +V++S+D RLW V G+ + Sbjct: 252 ---DMRTRIPVITLVGHKGPINQV---QCT-PVDPQ-VVSSSTDATVRLWDVVAGKTMKV 303 Query: 308 YGGHQKAVVCLAFN 321 H+++V A + Sbjct: 304 LTHHKRSVRATALH 317 Score = 36.6 bits (83), Expect = 0.015, Method: Compositional matrix adjust. Identities = 34/166 (20%), Positives = 66/166 (39%), Gaps = 12/166 (7%) Query: 11 DPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDL 70 DP +++++ D TVR W +G + + H V A + P +A+A IR + L Sbjct: 278 DPQVVSSST-DATVRLWDVVAGKTMKVLTHHKRSVRATALHPKEFSVASACTDDIRSWGL 336 Query: 71 NSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRS----RNLQCQRI-- 124 + + +++ I + ++ GG++ +D +S ++L + + Sbjct: 337 AEG--SLLTNFESEKTGIINTLSINQDDVLFAGGDNGVLSFYDYKSGHKYQSLATREMVG 394 Query: 125 -FQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEP 169 + + C LI G+ +I IW K D EP Sbjct: 395 SLEGERSVLCSTFDKTGLRLITGEADKSIKIW--KQDETATKESEP 438 Score = 35.4 bits (80), Expect = 0.035, Method: Compositional matrix adjust. Identities = 29/152 (19%), Positives = 53/152 (34%), Gaps = 9/152 (5%) Query: 96 DGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIW 155 D W TG D T ++WDL + L+ V + V + L + + W Sbjct: 151 DNEWFITGSNDTTMKVWDLATGKLKTTLAGHV-MTVRDVAVSDRHPYLFSVSEDKTVKCW 209 Query: 156 DLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTK 215 DL+ + + + + I P +A +W++ IP Sbjct: 210 DLEKNQIIRDYYGHLSGVRTVSIHPTLDLIATAGRDSVIKLWDM--------RTRIPVIT 261 Query: 216 IPAHTRYALQCRFSPDSTLLATCSADQTCKIW 247 + H Q + +P + + S D T ++W Sbjct: 262 LVGHKGPINQVQCTPVDPQVVSSSTDATVRLW 293 Score = 32.3 bits (72), Expect = 0.32, Method: Compositional matrix adjust. Identities = 16/53 (30%), Positives = 29/53 (54%), Gaps = 1/53 (1%) Query: 271 GWMWGCAFSG-DSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFND 322 GW+ A D+++ +T S+D ++W + TG++K GH V +A +D Sbjct: 140 GWVRCVAIDPVDNEWFITGSNDTTMKVWDLATGKLKTTLAGHVMTVRDVAVSD 192 >6ID0-T nrPDB Length = 514 Score = 46.6 bits (109), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 58/286 (20%), Positives = 104/286 (36%), Gaps = 18/286 (6%) Query: 15 LATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGY-QHIRMYDLNSN 73 T D T++ W SG ++ S V + V+ + + G + ++ +DL N Sbjct: 219 FVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYN 278 Query: 74 NPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINC 133 I Y G + + H + T D TARIWD+R++ NA Sbjct: 279 KV--IRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATV 336 Query: 134 VCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGN 193 C + ++I G I +WDL + + S+ + + P Y A S N Sbjct: 337 RC-QAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHP-RHYTFASGSPDN 394 Query: 194 CYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKI--WRTSN 251 W G + + H + D L++ + T + WRT Sbjct: 395 IKQWKFPDGSFIQ--------NLSGHNAIINTLTVNSDGVLVSGAD-NGTMHLWDWRTGY 445 Query: 252 FSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLW 297 +++ G+ S ++ CAF ++TA +D +++ Sbjct: 446 NFQRVHAAVQPGS--LDSESGIFACAFDQSESRLLTAEADKTIKVY 489 Score = 41.2 bits (95), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 39/191 (20%), Positives = 71/191 (37%), Gaps = 16/191 (8%) Query: 131 INCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNS 190 + C+ + P + G I IWDL + + + ++ + + Y+ + Sbjct: 207 VRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGE 266 Query: 191 TGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTS 250 W+L E ++I H P +L TCS D T +IW Sbjct: 267 DKQVKCWDL------EYNKVI--RHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVR 318 Query: 251 NFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGG 310 + + LS G ++ C + + Q I+T S D RLW + G+ + Sbjct: 319 TKASVHTLS------GHTNAVATVRCQ-AAEPQ-IITGSHDTTIRLWDLVAGKTRVTLTN 370 Query: 311 HQKAVVCLAFN 321 H+K+V + + Sbjct: 371 HKKSVRAVVLH 381 Score = 38.9 bits (89), Expect = 0.003, Method: Compositional matrix adjust. Identities = 27/95 (28%), Positives = 42/95 (44%), Gaps = 8/95 (8%) Query: 230 PDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTAS 289 P + T SAD+T KIW ++ L L+ G S + G S S Y+ + Sbjct: 214 PGNQWFVTGSADRTIKIWDLASGKLKLSLT------GHIST--VRGVIVSTRSPYLFSCG 265 Query: 290 SDNLARLWCVETGEIKREYGGHQKAVVCLAFNDSV 324 D + W +E ++ R Y GH AV L + ++ Sbjct: 266 EDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTI 300 Score = 36.6 bits (83), Expect = 0.015, Method: Compositional matrix adjust. Identities = 32/154 (20%), Positives = 62/154 (40%), Gaps = 6/154 (3%) Query: 14 ILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQH-IRMYDLNS 72 +L T D T R W + T+ + V + I + IR++DL + Sbjct: 302 VLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVA 361 Query: 73 NNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPIN 132 ++ K++ +V H + + G + W + Q + NA IN Sbjct: 362 GKTR--VTLTNHKKSVRAVVLHPR-HYTFASGSPDNIKQWKFPDGSF-IQNLSGHNAIIN 417 Query: 133 CVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLI 166 + ++ + L+ G +G +H+WD +T +N Q + Sbjct: 418 TLTVN-SDGVLVSGADNGTMHLWDWRTGYNFQRV 450 Score = 32.0 bits (71), Expect = 0.39, Method: Compositional matrix adjust. Identities = 14/45 (31%), Positives = 24/45 (53%) Query: 271 GWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAV 315 GW+ A +Q+ VT S+D ++W + +G++K GH V Sbjct: 205 GWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTV 249 Score = 29.3 bits (64), Expect = 2.4, Method: Compositional matrix adjust. Identities = 16/61 (26%), Positives = 26/61 (42%), Gaps = 1/61 (1%) Query: 98 RWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDL 157 +W TG D T +IWDL S L+ ++ + V + L + + WDL Sbjct: 217 QWFVTGSADRTIKIWDLASGKLKLSLTGHIST-VRGVIVSTRSPYLFSCGEDKQVKCWDL 275 Query: 158 K 158 + Sbjct: 276 E 276 >5OQL-L nrPDB Length = 557 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 42/156 (26%), Positives = 72/156 (46%), Gaps = 13/156 (8%) Query: 5 PGTVGSDPVILATAGYDHTVRFWQAHS-GICTRTVQHQDSQVNALEVTPDRSMIAAAGYQ 63 PG+ S+ +L + YD TVR W A + G T +H D + L + +++AA+G Sbjct: 197 PGSANSN--LLVSGSYDETVRVWDARAPGGAVMTFKHADPIEDVLPLPSGTTLLAASG-N 253 Query: 64 HIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQR 123 I + DL + P +I+ K + S+ GR + +G D ++++ S N+ Sbjct: 254 AISVLDLVAAKPLRLITNH--QKTVTSLSLASQGRRVVSGSLDGHVKVFETTSWNVVAGA 311 Query: 124 IFQVNAPINCVCLHPNQAE-----LIVGDQSGAIHI 154 + +PI + + A L VG QSG + I Sbjct: 312 KYP--SPILSLSVITAGASHDDRHLAVGMQSGVLSI 345 Score = 29.3 bits (64), Expect = 2.3, Method: Compositional matrix adjust. Identities = 33/128 (25%), Positives = 54/128 (42%), Gaps = 23/128 (17%) Query: 177 HIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSP-DSTLL 235 I PD + A TG V++ +G +I KT H + ++SP + T L Sbjct: 106 EIRPDGRVLVAGEDTGRMQVFD----VGQGTRAVILKT-WHIHKQPVWVTKWSPTELTTL 160 Query: 236 ATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRG---WMWGCAF---SGDSQYIVTAS 289 +CS D+T ++W + S +P G ++ AF S +S +V+ S Sbjct: 161 MSCSDDKTVRLW-----------DLPSNDPTRLFTGHTDYVRCGAFMPGSANSNLLVSGS 209 Query: 290 SDNLARLW 297 D R+W Sbjct: 210 YDETVRVW 217 >4A11-B nrPDB Length = 408 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 54/235 (22%), Positives = 98/235 (41%), Gaps = 38/235 (16%) Query: 96 DGRWMYTGGEDCTARIWDLRSRNLQ----CQRIFQVNA--------PINCVCLHPNQAEL 143 +GR+M +GG D ++DL + + Q C+ + + + V +P+ + Sbjct: 55 EGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGM 114 Query: 144 IVGDQ-SGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASY--MAAVNSTG-NCYVWNL 199 + +WD T + E ++ S H+ P ++ + AV + G + +L Sbjct: 115 FTSSSFDKTLKVWDTNTLQTADVFNFEE-TVYSHHMSPVSTKHCLVAVGTRGPKVQLCDL 173 Query: 200 TGGIGDEVTQLIPKTKIPAHTRYALQCRFSPD-STLLATCSADQTCKIW--RTSNFSLMT 256 G + Q H + L +SP +LAT SAD K+W R ++ L+T Sbjct: 174 KSGSCSHILQ--------GHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLIT 225 Query: 257 --------ELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGE 303 +++S N + G + G F+ D +++T +DN RLW GE Sbjct: 226 LDQHNGKKSQAVESANTAHN--GKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGE 278 >5N4A-A nrPDB Length = 771 Score = 45.8 bits (107), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 39/137 (28%), Positives = 63/137 (45%), Gaps = 7/137 (5%) Query: 11 DPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDL 70 D LATAG D +V+ W + +G+ T+ DS V ++ D + ++ + L Sbjct: 115 DGTALATAGEDGSVKIW-SRNGMLRSTLAQADSPVYSIVWAYDCDQLCYCTGSNVVIKSL 173 Query: 71 NSN-NPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNA 129 +SN N ++DGV + V + + TGGEDC ++WD R L +F + Sbjct: 174 SSNAKQNAWKAHDGV---VLKVDWSPINHLIITGGEDCKYKVWDSFGRLLFQSGLF--DY 228 Query: 130 PINCVCLHPNQAELIVG 146 P+ V P+ VG Sbjct: 229 PVTSVAWAPSGELFAVG 245 Score = 28.5 bits (62), Expect = 3.9, Method: Compositional matrix adjust. Identities = 28/115 (24%), Positives = 42/115 (36%), Gaps = 19/115 (16%) Query: 142 ELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDAS---------YMAAVNSTG 192 EL IH W++ EQ + + T H P +S A + G Sbjct: 27 ELFTCSDDQTIHKWNM-LGEPEQKVSTLDAYFTDMHWYPVSSKKTQAGGTDVFAVACTDG 85 Query: 193 NCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIW 247 + + + TG + + I H + R+S D T LAT D + KIW Sbjct: 86 SVKILSRTGRV---------EKSIEGHKGACISLRWSYDGTALATAGEDGSVKIW 131 >3JAP-g nrPDB Length = 326 Score = 45.1 bits (105), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 61/285 (21%), Positives = 98/285 (34%), Gaps = 76/285 (26%) Query: 77 PIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCL 136 P+ SY G + + V DG + + D T R+W+L + N + R + V + Sbjct: 58 PVRSYKGHSHIVQDVVVSADGNYAVSASWDKTLRLWNLATGNSEA-RFVGHTGDVLSVAI 116 Query: 137 HPNQAELIVGDQSGAIHIWDLKTD-------HNEQL--------------IPEPEVSITS 175 N +++I + I +W+ D H + + + + ++ S Sbjct: 117 DANSSKIISASRDKTIRVWNTVGDCAYVLLGHTDWVTKVRVAPKNLEDGEVDDGRITFVS 176 Query: 176 AHID--------------------------------PDASYMAAVNSTGNCYVWNLTGGI 203 A +D PD S A+ G YVWNL Sbjct: 177 AGMDKIVRSWSLNEDSYRIEADFIGHNNYINVVQPSPDGSLAASAGKDGQIYVWNLKH-- 234 Query: 204 GDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELS---- 259 K ++ +AL FSP L +A KI+ N L+ EL Sbjct: 235 KSAFMNFDAKDEV-----FALA--FSPSRFWLTAATA-SGIKIYDLENEVLIDELKPEFA 286 Query: 260 --IKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETG 302 K+ +P S W S D Q + +DN+ R+W V T Sbjct: 287 GYTKAQDPHAVSLAW------SADGQTLFAGYTDNVIRVWQVMTA 325 Score = 42.0 bits (97), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 47/185 (25%), Positives = 73/185 (39%), Gaps = 20/185 (10%) Query: 15 LATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPD----------RSMIAAAGYQH 64 + +A D T+R W G C + V + V P R +AG Sbjct: 123 IISASRDKTIRVWNT-VGDCAYVLLGHTDWVTKVRVAPKNLEDGEVDDGRITFVSAGMDK 181 Query: 65 I-RMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQR 123 I R + LN ++ + G N I V DG + G+D +W+L+ ++ Sbjct: 182 IVRSWSLNEDSYRIEADFIGHNNYINVVQPSPDGSLAASAGKDGQIYVWNLKHKSAFMN- 240 Query: 124 IFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPE--PEVSITSAHIDPD 181 F + + P++ L SG I I+DL+ NE LI E PE + + DP Sbjct: 241 -FDAKDEVFALAFSPSRFWLTAATASG-IKIYDLE---NEVLIDELKPEFAGYTKAQDPH 295 Query: 182 ASYMA 186 A +A Sbjct: 296 AVSLA 300 Score = 40.0 bits (92), Expect = 0.001, Method: Compositional matrix adjust. Identities = 29/91 (31%), Positives = 42/91 (46%), Gaps = 9/91 (9%) Query: 234 LLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRG---WMWGCAFSGDSQYIVTASS 290 LL + S D+T WR +TE + G P S +G + S D Y V+AS Sbjct: 33 LLVSGSRDKTLISWR------LTENEQQFGVPVRSYKGHSHIVQDVVVSADGNYAVSASW 86 Query: 291 DNLARLWCVETGEIKREYGGHQKAVVCLAFN 321 D RLW + TG + + GH V+ +A + Sbjct: 87 DKTLRLWNLATGNSEARFVGHTGDVLSVAID 117 Score = 37.7 bits (86), Expect = 0.008, Method: Compositional matrix adjust. Identities = 53/254 (20%), Positives = 106/254 (41%), Gaps = 19/254 (7%) Query: 8 VGSDPVILATAGYDHTVRFWQAHSGIC-TRTVQHQDSQVNALEVTPDRSMIAAAGYQHIR 66 V +D +A +D T+R W +G R V H ++ +I+A+ + IR Sbjct: 74 VSADGNYAVSASWDKTLRLWNLATGNSEARFVGHTGDVLSVAIDANSSKIISASRDKTIR 133 Query: 67 MYDLNSNNPNPIISY-DGVN------KNIASVGFHEDGRWMY-TGGEDCTARIWDLRSRN 118 +++ + ++ + D V KN+ G +DGR + + G D R W L + Sbjct: 134 VWNTVGDCAYVLLGHTDWVTKVRVAPKNLED-GEVDDGRITFVSAGMDKIVRSWSLNEDS 192 Query: 119 LQCQRIF-QVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIP-EPEVSITSA 176 + + F N IN V P+ + + G I++W+LK H + + + + + Sbjct: 193 YRIEADFIGHNNYINVVQPSPDGSLAASAGKDGQIYVWNLK--HKSAFMNFDAKDEVFAL 250 Query: 177 HIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTK--IPAHTRYALQCRFSPDSTL 234 P ++ A ++G +++L + + +L P+ A +A+ +S D Sbjct: 251 AFSPSRFWLTAATASG-IKIYDLENEV--LIDELKPEFAGYTKAQDPHAVSLAWSADGQT 307 Query: 235 LATCSADQTCKIWR 248 L D ++W+ Sbjct: 308 LFAGYTDNVIRVWQ 321 Score = 36.6 bits (83), Expect = 0.015, Method: Compositional matrix adjust. Identities = 27/114 (23%), Positives = 47/114 (41%), Gaps = 7/114 (6%) Query: 11 DPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDL 70 D + A+AG D + W +D +V AL +P R + AA I++YDL Sbjct: 214 DGSLAASAGKDGQIYVWNLKHKSAFMNFDAKD-EVFALAFSPSRFWLTAATASGIKIYDL 272 Query: 71 NSN------NPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRN 118 + P + + S+ + DG+ ++ G D R+W + + N Sbjct: 273 ENEVLIDELKPEFAGYTKAQDPHAVSLAWSADGQTLFAGYTDNVIRVWQVMTAN 326 Score = 33.1 bits (74), Expect = 0.16, Method: Compositional matrix adjust. Identities = 28/121 (23%), Positives = 57/121 (47%), Gaps = 7/121 (5%) Query: 2 NTSPGTVGSDPVILATAGYDHTVRFWQAHSG---ICTRTVQHQDSQVNALEVTPDRSMIA 58 N G V + +AG D VR W + I + H ++ +N ++ +PD S+ A Sbjct: 161 NLEDGEVDDGRITFVSAGMDKIVRSWSLNEDSYRIEADFIGH-NNYINVVQPSPDGSLAA 219 Query: 59 AAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRN 118 +AG + ++Y N + + +++D ++ + ++ F W+ T +I+DL + Sbjct: 220 SAG-KDGQIYVWNLKHKSAFMNFDAKDE-VFALAFSPSRFWL-TAATASGIKIYDLENEV 276 Query: 119 L 119 L Sbjct: 277 L 277 Score = 28.1 bits (61), Expect = 5.1, Method: Compositional matrix adjust. Identities = 24/114 (21%), Positives = 42/114 (36%), Gaps = 17/114 (14%) Query: 143 LIVGDQSGAIHIWDLKTDHNEQLIPEPEVS-------ITSAHIDPDASYMAAVNSTGNCY 195 L+ G + + W L NEQ P S + + D +Y + + Sbjct: 34 LVSGSRDKTLISWRLT--ENEQQFGVPVRSYKGHSHIVQDVVVSADGNYAVSASWDKTLR 91 Query: 196 VWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRT 249 +WNL G + + HT L +S+ + + S D+T ++W T Sbjct: 92 LWNLATGNSE--------ARFVGHTGDVLSVAIDANSSKIISASRDKTIRVWNT 137 >4BTS-AR nrPDB Length = 343 Score = 44.7 bits (104), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 37/189 (19%), Positives = 72/189 (38%), Gaps = 22/189 (11%) Query: 77 PIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCL 136 P + G N ++ + ++ + + D T R+WDLR+ +R + + V Sbjct: 68 PHKALTGHNHFVSDLALSQENCFAISSSWDKTLRLWDLRT-GTTYKRFVGHQSEVYSVAF 126 Query: 137 HPNQAELIVGDQSGAIHIWDL----------KTDHNEQL--IPEPEVSITSAHIDPDASY 184 P+ +++ I +W++ K +H++ + + + ++ + P A Y Sbjct: 127 SPDNRQILSAGAEREIKLWNILGECKFSSAEKENHSDWVSCVRYSPIMKSANKVQPFAPY 186 Query: 185 MAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTC 244 A+V G VWN T + AH SP+ +AT D+ Sbjct: 187 FASVGWDGRLKVWN---------TNFQIRYTFKAHESNVNHLSISPNGKYIATGGKDKKL 237 Query: 245 KIWRTSNFS 253 IW N + Sbjct: 238 LIWDILNLT 246 Score = 42.4 bits (98), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 39/195 (20%), Positives = 76/195 (38%), Gaps = 54/195 (27%) Query: 17 TAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPD-RSMIAAAGYQHIRMYDL----- 70 ++ +D T+R W +G + S+V ++ +PD R +++A + I+++++ Sbjct: 93 SSSWDKTLRLWDLRTGTTYKRFVGHQSEVYSVAFSPDNRQILSAGAEREIKLWNILGECK 152 Query: 71 -----------------------NSNNPNPIISY------DGVNK--------------- 86 ++N P Y DG K Sbjct: 153 FSSAEKENHSDWVSCVRYSPIMKSANKVQPFAPYFASVGWDGRLKVWNTNFQIRYTFKAH 212 Query: 87 --NIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELI 144 N+ + +G+++ TGG+D IWD+ + QR F + IN + +P + Sbjct: 213 ESNVNHLSISPNGKYIATGGKDKKLLIWDILNLTYP-QREFDAGSTINQIAFNPKLQWVA 271 Query: 145 VGDQSGAIHIWDLKT 159 VG G + I++L T Sbjct: 272 VGTDQG-VKIFNLMT 285 Score = 38.9 bits (89), Expect = 0.003, Method: Compositional matrix adjust. Identities = 27/94 (28%), Positives = 47/94 (50%), Gaps = 7/94 (7%) Query: 231 DSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRG---WMWGCAFSGDSQYIVT 287 DS +L + S D+T IW+ E + G P ++ G ++ A S ++ + ++ Sbjct: 38 DSPVLISGSRDKTVMIWKLYE----EEQNGYFGIPHKALTGHNHFVSDLALSQENCFAIS 93 Query: 288 ASSDNLARLWCVETGEIKREYGGHQKAVVCLAFN 321 +S D RLW + TG + + GHQ V +AF+ Sbjct: 94 SSWDKTLRLWDLRTGTTYKRFVGHQSEVYSVAFS 127 Score = 32.3 bits (72), Expect = 0.29, Method: Compositional matrix adjust. Identities = 39/216 (18%), Positives = 72/216 (33%), Gaps = 19/216 (8%) Query: 94 HEDGRWMYTGGEDCTARIWDLRSRN------LQCQRIFQVNAPINCVCLHPNQAELIVGD 147 +ED + +G D T IW L + + + N ++ + L I Sbjct: 36 NEDSPVLISGSRDKTVMIWKLYEEEQNGYFGIPHKALTGHNHFVSDLALSQENCFAISSS 95 Query: 148 QSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEV 207 + +WDL+T + + + S PD + + + +WN+ G Sbjct: 96 WDKTLRLWDLRTGTTYKRFVGHQSEVYSVAFSPDNRQILSAGAEREIKLWNILGECKFSS 155 Query: 208 TQLIPKTKIPAHTRYA----LQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSG 263 + + + RY+ + P + A+ D K+W T NF + Sbjct: 156 AEKENHSDWVSCVRYSPIMKSANKVQPFAPYFASVGWDGRLKVWNT-NFQIRYTFKAHES 214 Query: 264 NPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCV 299 N S S + +YI T D +W + Sbjct: 215 NVNHLS--------ISPNGKYIATGGKDKKLLIWDI 242 >5OQL-J nrPDB Length = 912 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 75/347 (21%), Positives = 128/347 (36%), Gaps = 83/347 (23%) Query: 41 QDSQVNALEVTPDRSMIA-AAGYQHIRMYDLN-----SNNPNPIISYDGVNKNIASVGFH 94 D ++ + PD+SM+A A + IR+ + S + S ++A + H Sbjct: 373 HDEILDLTYILPDQSMMAIATNSEDIRIVSVKDAQAYSEDNAECRSGSYFGHDVALLKGH 432 Query: 95 ED----------GRWMYTGGEDCTARIW--DLRSRNLQCQRIF-------------QVNA 129 ED G W+ +G +D TAR+W D + + C +F +V Sbjct: 433 EDIVMSLDVDWSGHWIASGSKDNTARLWRVDPANNSYTCYAVFTGHLESVGAVALPKVVP 492 Query: 130 PINCVCL-----HPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVS-----------I 173 P N HP A LI G Q + K D QL +++ I Sbjct: 493 PANSEAFKNPLDHP-PAFLISGSQDRFVQ----KRDIPRQLQKGGKLTSSLRRLAHDKDI 547 Query: 174 TSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDST 233 + I P+ A+ + +W+ V +L + + H R RF+P +T Sbjct: 548 NALDISPNGKLFASASQDKTVKIWD--------VEKLEVQGILRGHKRGVWTVRFAPLNT 599 Query: 234 --------------LLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFS 279 ++ T S D+T K+W S+++ + S N + +W Sbjct: 600 PVIQGEQGSVSGRGVVLTGSGDKTIKLWNLSDYTCIRTFEGHSHNVLKV----VWLHISR 655 Query: 280 GDS-----QYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFN 321 DS +A +D L ++W TGE + H+ + LA + Sbjct: 656 DDSITKTKVQFASAGADTLVKVWDANTGETECTLDNHEDRLWTLAVH 702 Score = 36.2 bits (82), Expect = 0.021, Method: Compositional matrix adjust. Identities = 13/26 (50%), Positives = 17/26 (65%) Query: 88 IASVGFHEDGRWMYTGGEDCTARIWD 113 + SVGF +G+WMY+ G RIWD Sbjct: 277 LESVGFLNEGKWMYSAGTSGVLRIWD 302 Score = 32.0 bits (71), Expect = 0.36, Method: Compositional matrix adjust. Identities = 52/243 (21%), Positives = 90/243 (37%), Gaps = 28/243 (11%) Query: 14 ILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLNSN 73 +LAT D ++ W G T TV V+AL ++ + S+ Sbjct: 125 LLATGAADGAIKIWDIIGGYVTHTVSGPSVLVSALHF-----------FEIAVTAESQSS 173 Query: 74 NPNPII-SYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNL-----QCQRIFQV 127 N P S G N + + W G +D RI+DL R +R + Sbjct: 174 NKKPKKGSRKGQNDDADEIASRFRLAW---GTQDGRIRIFDLYKRTTTPVYADPKRKKEA 230 Query: 128 N-APINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVS-ITSAHIDPDASYM 185 + + + C+ P Q L+ G + + +W L D Q P + S + +M Sbjct: 231 HESNVQCIAYSPEQHALLSGSRDKTMTLW-LWRDGIWQGTPMLRHELLESVGFLNEGKWM 289 Query: 186 AAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCK 245 + ++G +W+ T E+T+ K + L P+ +L+ AD T Sbjct: 290 YSAGTSGVLRIWDTT--THHEITK---KQDAKSEGEAILSAVSLPERSLILCAQADFTLV 344 Query: 246 IWR 248 ++R Sbjct: 345 LYR 347 Score = 28.5 bits (62), Expect = 3.9, Method: Compositional matrix adjust. Identities = 18/81 (22%), Positives = 36/81 (44%), Gaps = 8/81 (9%) Query: 130 PINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAH--------IDPD 181 PI+ + + P+ + LIV +S + I+ L + + V T H +D Sbjct: 63 PISTLTITPSGSHLIVCSRSLTMRIYSLAISPDYDSVEPTLVRTTKPHATPVVVLAVDRT 122 Query: 182 ASYMAAVNSTGNCYVWNLTGG 202 ++ +A + G +W++ GG Sbjct: 123 STLLATGAADGAIKIWDIIGG 143 Score = 27.7 bits (60), Expect = 6.5, Method: Compositional matrix adjust. Identities = 26/117 (22%), Positives = 48/117 (41%), Gaps = 13/117 (11%) Query: 6 GTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQ---HQDSQVNALEVTPDRSM------ 56 G+V V+L +G D T++ W C RT + H +V L ++ D S+ Sbjct: 607 GSVSGRGVVLTGSG-DKTIKLWNLSDYTCIRTFEGHSHNVLKVVWLHISRDDSITKTKVQ 665 Query: 57 IAAAGYQH-IRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIW 112 A+AG ++++D N+ + D + ++ H + + G D W Sbjct: 666 FASAGADTLVKVWDANTGETE--CTLDNHEDRLWTLAVHSKTNILASAGSDSKVTFW 720 >5MWJ-A nrPDB Length = 337 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 56/218 (25%), Positives = 89/218 (40%), Gaps = 39/218 (17%) Query: 42 DSQVNALEVTPDRSMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMY 101 D Q+ + PD ++I +H R +N+ N ++ +V R +Y Sbjct: 20 DGQMQPVPFPPD-ALIGPGIPRHARQ--INTLNHGEVV---------CAVTISNPTRHVY 67 Query: 102 TGGEDCTARIWDL-----RSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWD 156 TGG+ C ++WD+ +S Q + + N +C L P+ LIVG ++ + IWD Sbjct: 68 TGGKGCV-KVWDISHPGNKSPVSQLDCLNRDNYIRSCKLL-PDGCTLIVGGEASTLSIWD 125 Query: 157 LKTDHNEQLIPEPEVSITSA-------HIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQ 209 L P + +TS+ I PD+ + S GN VW+L Q Sbjct: 126 LAAP-----TPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLH-------NQ 173 Query: 210 LIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIW 247 + + + HT A S D T L T D T + W Sbjct: 174 TLVR-QFQGHTDGASCIDISNDGTKLWTGGLDNTVRSW 210 Score = 37.0 bits (84), Expect = 0.013, Method: Compositional matrix adjust. Identities = 34/121 (28%), Positives = 54/121 (44%), Gaps = 7/121 (5%) Query: 47 ALEVTPDRSM-IAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGE 105 AL ++PD + + +I ++DL+ N + + G + + DG ++TGG Sbjct: 146 ALAISPDSKVCFSCCSDGNIAVWDLH--NQTLVRQFQGHTDGASCIDISNDGTKLWTGGL 203 Query: 106 DCTARIWDLRS-RNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQ 164 D T R WDLR R LQ Q F + I + P L VG +S + + + Q Sbjct: 204 DNTVRSWDLREGRQLQ-QHDF--TSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDKYQ 260 Query: 165 L 165 L Sbjct: 261 L 261 Score = 32.7 bits (73), Expect = 0.22, Method: Compositional matrix adjust. Identities = 29/107 (27%), Positives = 45/107 (42%), Gaps = 7/107 (6%) Query: 8 VGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQD--SQVNALEVTPDRSMIAAAGYQHI 65 + +D L T G D+TVR W G R +Q D SQ+ +L P + A G + Sbjct: 191 ISNDGTKLWTGGLDNTVRSWDLREG---RQLQQHDFTSQIFSLGYCPTGEWL-AVGMESS 246 Query: 66 RMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIW 112 + L+ N P+ + S+ F G+W + G+D W Sbjct: 247 NVEVLHVNKPDK-YQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAW 292 Score = 32.3 bits (72), Expect = 0.29, Method: Compositional matrix adjust. Identities = 21/97 (21%), Positives = 35/97 (36%), Gaps = 6/97 (6%) Query: 222 YALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGD 281 Y C+ PD L T IW + + + + S P + A S D Sbjct: 99 YIRSCKLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPA------CYALAISPD 152 Query: 282 SQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCL 318 S+ + SD +W + + R++ GH C+ Sbjct: 153 SKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCI 189 >5K19-A nrPDB Length = 569 Score = 42.7 bits (99), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 54/230 (23%), Positives = 94/230 (40%), Gaps = 39/230 (16%) Query: 122 QRIFQVNAP----INCVCLHPNQAELIVGDQSGAIHIWDL------KTDHNEQLIPEPEV 171 +RI++ P N + L+VG +G + + D K + E+LI + V Sbjct: 93 KRIYKGTQPTCHDFNHLTATAESVSLLVGFSAGQVQLIDPIKKETSKLFNEERLIDKSRV 152 Query: 172 SITSAHIDPDASYMAAVNSTGNCYVWNL--TGGIGDEVTQLIPKTK-IPAHTRYALQCR- 227 + ++ ++ A +S+GN Y++N+ T G QL+ + + HT + R Sbjct: 153 TCVKWVPGSESLFLVA-HSSGNMYLYNVEHTCGTTAPHYQLLKQGESFAVHTCKSKSTRN 211 Query: 228 ----------------FSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRG 271 FSPD LA S D +++ NF S++ +S G Sbjct: 212 PLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVF---NFD-----SVELHGTMKSYFG 263 Query: 272 WMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFN 321 + +S D +YIVT D+L +W + GH+ V +AF+ Sbjct: 264 GLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFD 313 Score = 27.7 bits (60), Expect = 7.3, Method: Compositional matrix adjust. Identities = 18/75 (24%), Positives = 35/75 (46%), Gaps = 5/75 (6%) Query: 42 DSQVNALEVTPDRSMIAAAGYQ-HIRMYDLNSNNPNPII-SYDGVNKNIASVGFHEDGRW 99 + +N +PD +A +R+++ +S + + SY G + V + DG++ Sbjct: 220 EGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFG---GLLCVCWSPDGKY 276 Query: 100 MYTGGEDCTARIWDL 114 + TGGED +W Sbjct: 277 IVTGGEDDLVTVWSF 291 >5BJS-A nrPDB Length = 605 Score = 42.4 bits (98), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 28/111 (25%), Positives = 51/111 (45%), Gaps = 6/111 (5%) Query: 10 SDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQH--IRM 67 +D +L AG + V+ + G RT+ +N L +P I A+ IR+ Sbjct: 146 TDQPLLCIAGNEGNVKVYNVTEGKLYRTLVGHGGGINDLATSPANPYIIASASDDTTIRI 205 Query: 68 YDLNSNNPNP----IISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDL 114 + L + I+ +G + ++ SV FH++GR++ + G D +W L Sbjct: 206 WSLAPEHEKQPCVCILGGEGHSYDLLSVAFHDNGRYVLSAGHDQVINLWAL 256 >6CHG-D nrPDB Length = 439 Score = 42.0 bits (97), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 45/201 (22%), Positives = 91/201 (45%), Gaps = 30/201 (14%) Query: 65 IRMYDLNSNNPNPII-SYDGVN-KNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQ 122 I +YD++S P ++ ++ G + +++ SV + DGR++++ G D A++WD+ ++ +C Sbjct: 51 IIIYDMDSLKPIAMLGTHSGAHTRSVQSVCWSNDGRYLWSSGRDWYAKLWDM-TQPTKCF 109 Query: 123 RIFQVNAPI-NC------VCL-----HPNQAELIVGDQSGAIHIWDLK------TDHNEQ 164 + ++ + P+ +C VC+ P L + D+ A H + L + H Sbjct: 110 QQYKFDGPLWSCHVVRWNVCIVTVVEEPTAYVLTLTDRQNAFHCFPLLEQDQDISGHGYT 169 Query: 165 LIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYAL 224 L+ P +I S I N + +L G D++ + A+ + Sbjct: 170 LVACPHPTIESIII------TGTSKGWINAFQLDLESGFEDKIRCCYEEKIANANIK--- 220 Query: 225 QCRFSPDSTLLATCSADQTCK 245 Q SP T +A +D+T + Sbjct: 221 QIIISPSGTRIAINGSDRTIR 241 >5CXC-A nrPDB Length = 510 Score = 42.0 bits (97), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 38/126 (30%), Positives = 60/126 (47%), Gaps = 10/126 (7%) Query: 1 MNTSPGTVG----SDPVILATAGYDHTVRFWQAHSG--ICTRTVQHQDSQVNALEVTPDR 54 ++T+P T D + +A DHTVR +G + T T+ H ++AL Sbjct: 310 IHTAPATAAIFDPRDRTVAYSASQDHTVRTLDLTTGQVVSTLTLTHPLLSLSALTRAGTT 369 Query: 55 SMIAAAGY--QHIRMYDLN-SNNPNPIISYDG-VNKNIASVGFHEDGRWMYTGGEDCTAR 110 S + AAG +HI M D S+ +++ G NK ++ E+ + +G D T R Sbjct: 370 SPLLAAGTSARHITMVDPRASSATTSVMTLRGHANKVVSLSPSPENEYSLVSGSHDGTCR 429 Query: 111 IWDLRS 116 +WDLRS Sbjct: 430 VWDLRS 435 >5XYI-g nrPDB Length = 335 Score = 41.6 bits (96), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 43/231 (18%), Positives = 85/231 (36%), Gaps = 18/231 (7%) Query: 77 PIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQ----CQRIFQVNAPIN 132 P ++ G N I S+ + ++ + D +A +W L Q R+ N ++ Sbjct: 25 PRATFVGHNAAIESIEIDNEHNYLVSASRDKSALVWKLNRTQEQWATPFTRLIGHNHFVS 84 Query: 133 CVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTG 192 V L + + L+ + +WDL T ++L + + P + +V Sbjct: 85 DVSLSRDASHLLTSSWDSTLRLWDLSTRTTKKLFLGHKKDVLGVTFSPCNRRIISVGRDN 144 Query: 193 NCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNF 252 +WN+ +G+ +L + + + + SP ++A D IW Sbjct: 145 QVKIWNI---LGENKAELQCSSWVTSVACAPMADETSP--LVIAVGCWDGKVYIWSIEKE 199 Query: 253 S-LMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETG 302 + L+ E G F+ D ++++T SD +W E G Sbjct: 200 AKLIKEFKAHDGRCTSVD--------FTPDGKWVITGGSDRKVVMWLTENG 242 Score = 40.0 bits (92), Expect = 0.001, Method: Compositional matrix adjust. Identities = 34/136 (25%), Positives = 60/136 (44%), Gaps = 12/136 (8%) Query: 172 SITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPD 231 +I S ID + +Y+ + + + VW L T P T++ H + S D Sbjct: 35 AIESIEIDNEHNYLVSASRDKSALVWKLNRTQEQWAT---PFTRLIGHNHFVSDVSLSRD 91 Query: 232 STLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSD 291 ++ L T S D T ++W + S T + G+ + + G FS ++ I++ D Sbjct: 92 ASHLLTSSWDSTLRLW---DLSTRTTKKLFLGHKKD-----VLGVTFSPCNRRIISVGRD 143 Query: 292 NLARLWCVETGEIKRE 307 N ++W + GE K E Sbjct: 144 NQVKIWNI-LGENKAE 158 Score = 37.4 bits (85), Expect = 0.010, Method: Compositional matrix adjust. Identities = 23/77 (29%), Positives = 34/77 (44%), Gaps = 3/77 (3%) Query: 90 SVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQS 149 SV F DG+W+ TGG D +W + N F +P++ V P QA + Sbjct: 215 SVDFTPDGKWVITGGSDRKVVMW--LTENGAKTISFTAPSPVHAVAACPTQAWICAATYE 272 Query: 150 GAIHIWDLKTDHNEQLI 166 G I +WD+ L+ Sbjct: 273 G-IAVWDIGAKQQIDLV 288 Score = 37.0 bits (84), Expect = 0.013, Method: Compositional matrix adjust. Identities = 27/109 (24%), Positives = 49/109 (44%), Gaps = 10/109 (9%) Query: 17 TAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLNSNNP- 75 T G D V W +G T + S V+A+ P ++ I AA Y+ I ++D+ + Sbjct: 227 TGGSDRKVVMWLTENGAKTISFT-APSPVHAVAACPTQAWICAATYEGIAVWDIGAKQQI 285 Query: 76 ---NPIISYDGVNK-----NIASVGFHEDGRWMYTGGEDCTARIWDLRS 116 P ++G + + + DG +Y+G D + R W+++S Sbjct: 286 DLVQPNFKHEGKRNAGRTPDCTCLAWAADGSVLYSGYNDGSIRAWEVKS 334 Score = 34.7 bits (78), Expect = 0.065, Method: Compositional matrix adjust. Identities = 15/45 (33%), Positives = 29/45 (64%) Query: 277 AFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFN 321 + S D+ +++T+S D+ RLW + T K+ + GH+K V+ + F+ Sbjct: 87 SLSRDASHLLTSSWDSTLRLWDLSTRTTKKLFLGHKKDVLGVTFS 131 >4U1E-I nrPDB Length = 347 Score = 41.2 bits (95), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 23/89 (25%), Positives = 40/89 (44%), Gaps = 8/89 (8%) Query: 215 KIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMW 274 K+ H R Q +++ + LL +CS D + +W + N + L + G +W Sbjct: 5 KLTGHERPLTQVKYNKEGDLLFSCSKDSSASVWYSLNGERLGTL--------DGHTGTIW 56 Query: 275 GCAFSGDSQYIVTASSDNLARLWCVETGE 303 ++Y VT S+D +LW V G+ Sbjct: 57 SIDVDCFTKYCVTGSADYSIKLWDVSNGQ 85 Score = 33.1 bits (74), Expect = 0.19, Method: Compositional matrix adjust. Identities = 36/171 (21%), Positives = 65/171 (38%), Gaps = 13/171 (7%) Query: 98 RWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELI-----VGDQSGAI 152 ++ TG D + ++WD+ N QC ++ P+ V P + V G+I Sbjct: 65 KYCVTGSADYSIKLWDVS--NGQCVATWKSPVPVKRVEFSPCGNYFLAILDNVMKNPGSI 122 Query: 153 HIWDLKTD---HNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGI---GDE 206 +I++++ D H + E + H DA+ +A ++ G + G D Sbjct: 123 NIYEIERDSATHELTKVSEEPIHKIITHEGLDAATVAGWSTKGKYIIAGHKDGKISKYDV 182 Query: 207 VTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTE 257 I H + +FSPD T T S D + S ++ + Sbjct: 183 SNNYEYVDSIDLHEKSISDMQFSPDLTYFITSSRDTNSFLVDVSTLQVLKK 233 >3ODT-A nrPDB Length = 313 Score = 40.8 bits (94), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 68/292 (23%), Positives = 120/292 (41%), Gaps = 34/292 (11%) Query: 15 LATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHI--RMYDLNS 72 +A+ D TVR W V +N++ ++ ++ G + + + Sbjct: 32 VASVSRDGTVRLWSKDDQWLGTVVYTGQGFLNSVCYDSEKELLLFGGKDTMINGVPLFAT 91 Query: 73 NNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRS--RNLQCQRIFQVNAP 130 + +P+ + G N+ S+ F +DG + +G D TA++W S NLQ +A Sbjct: 92 SGEDPLYTLIGHQGNVCSLSF-QDGV-VISGSWDKTAKVWKEGSLVYNLQAHNASVWDAK 149 Query: 131 INCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNS 190 + V N+ D++ I +W N+++I T + I D AV Sbjct: 150 V--VSFSENKFLTASADKT--IKLW-----QNDKVIK------TFSGIHNDVVRHLAVVD 194 Query: 191 TGNCYVWNLTGGIG--DEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWR 248 G+ + G I D T + +T H + + P+ +++ C D+T +IW Sbjct: 195 DGHFISCSNDGLIKLVDMHTGDVLRT-YEGHESFVYCIKLLPNGDIVS-CGEDRTVRIWS 252 Query: 249 TSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVE 300 N SL +++ P S W C +GD I+ SSDNL R++ E Sbjct: 253 KENGSLKQVITL----PAISI--WSVDCMSNGD---IIVGSSDNLVRIFSQE 295 Score = 35.0 bits (79), Expect = 0.048, Method: Compositional matrix adjust. Identities = 28/93 (30%), Positives = 43/93 (46%), Gaps = 12/93 (12%) Query: 228 FSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVT 287 FS + L T SAD+T K+W+ + SG + R A D +I + Sbjct: 153 FSENKFL--TASADKTIKLWQNDKV-----IKTFSGIHNDVVRH----LAVVDDGHFI-S 200 Query: 288 ASSDNLARLWCVETGEIKREYGGHQKAVVCLAF 320 S+D L +L + TG++ R Y GH+ V C+ Sbjct: 201 CSNDGLIKLVDMHTGDVLRTYEGHESFVYCIKL 233 >6BX3-A nrPDB Length = 314 Score = 40.8 bits (94), Expect = 9e-04, Method: Compositional matrix adjust. Identities = 32/154 (20%), Positives = 63/154 (40%), Gaps = 20/154 (12%) Query: 80 SYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWD------LRSRNLQCQRIFQVNAPINC 133 ++ G + S+ F+ G ++T D + +IWD +++ + + + V+ P+N Sbjct: 90 TFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMN- 148 Query: 134 VCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPE--------VSITSAHIDPDASYM 185 + + L G G I I+D +T H + + + V I+ +A Y+ Sbjct: 149 -----DSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYL 203 Query: 186 AAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAH 219 + G +W+ GG Q+ P K H Sbjct: 204 LVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLH 237 Score = 35.0 bits (79), Expect = 0.039, Method: Compositional matrix adjust. Identities = 27/86 (31%), Positives = 36/86 (41%), Gaps = 7/86 (8%) Query: 218 AHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCA 277 HT + F+ LL T S D++ KIW T N SLM +S S Sbjct: 93 GHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVD-------V 145 Query: 278 FSGDSQYIVTASSDNLARLWCVETGE 303 DS + + S D L R++ ETG Sbjct: 146 PMNDSSILSSGSYDGLIRIFDAETGH 171 Score = 35.0 bits (79), Expect = 0.043, Method: Compositional matrix adjust. Identities = 35/152 (23%), Positives = 64/152 (42%), Gaps = 19/152 (12%) Query: 174 TSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDST 233 T A I PD ++A N ++++ + + +T + +H R + +SPD Sbjct: 16 TCAKISPDGQFLAITQGL-NILIYDIN-------RRTVSQTLVTSHARPFSELCWSPDGQ 67 Query: 234 LLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNL 293 +AT S D + +I S L T + G ++ + F+ + T+S D Sbjct: 68 CIATASDDFSVEIIHLSYGLLHTFI-------GHTAP--VISLTFNRKGNLLFTSSMDES 118 Query: 294 ARLWCVETGEIKREYGGHQKAVVC--LAFNDS 323 ++W G + + H +AVV + NDS Sbjct: 119 IKIWDTLNGSLMKTISAHSEAVVSVDVPMNDS 150 >4E5Z-B nrPDB Length = 436 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 22/74 (29%), Positives = 34/74 (45%), Gaps = 3/74 (4%) Query: 99 WMYTGGEDCTARIWDLRSRNLQCQRIFQV--NAPINCVCLHPNQAELIVGDQSGAIHIWD 156 ++ T D T +IWDLR + ++ + P+N C P+ A L+ DQ I ++ Sbjct: 265 FLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYS 324 Query: 157 LKT-DHNEQLIPEP 169 D LIP P Sbjct: 325 ASQWDCPLGLIPHP 338 >2P9P-C nrPDB Length = 372 Score = 39.3 bits (90), Expect = 0.002, Method: Compositional matrix adjust. Identities = 33/144 (22%), Positives = 60/144 (41%), Gaps = 2/144 (1%) Query: 53 DRSMIAAAGYQH-IRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARI 111 DR+ IA H + +Y+ + N + N + V + D + T G D A + Sbjct: 19 DRTQIAICPNNHEVHIYEKSGNKWVQVHELKEHNGQVTGVDWAPDSNRIVTCGTDRNAYV 78 Query: 112 WDLRSRNLQ-CQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPE 170 W L+ R + I ++N CV PN+ + VG S I I + +++ + + Sbjct: 79 WTLKGRTWKPTLVILRINRAARCVRWAPNEKKFAVGSGSRVISICYFEQENDWWVCKHIK 138 Query: 171 VSITSAHIDPDASYMAAVNSTGNC 194 I S + D + + + G+C Sbjct: 139 KPIRSTVLSLDWHPNSVLLAAGSC 162 Score = 30.8 bits (68), Expect = 0.83, Method: Compositional matrix adjust. Identities = 25/119 (21%), Positives = 48/119 (40%), Gaps = 8/119 (6%) Query: 130 PINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQL--IPEPEVSITSAHIDPDASYMAA 187 PI+C + ++ ++ + + +HI++ + Q+ + E +T PD++ + Sbjct: 10 PISCHAWNKDRTQIAICPNNHEVHIYEKSGNKWVQVHELKEHNGQVTGVDWAPDSNRIVT 69 Query: 188 VNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKI 246 + N YVW L G P I R A R++P+ A S + I Sbjct: 70 CGTDRNAYVWTLKG------RTWKPTLVILRINRAARCVRWAPNEKKFAVGSGSRVISI 122 >2HES-X nrPDB Length = 330 Score = 38.9 bits (89), Expect = 0.003, Method: Compositional matrix adjust. Identities = 34/106 (32%), Positives = 43/106 (40%), Gaps = 17/106 (16%) Query: 210 LIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIW-------RTSNFSLMTELSIKS 262 LI AH + + P ++LLA S D T IW RT L L+I Sbjct: 48 LIDVLDETAHKKAIRSVAWRPHTSLLAAGSFDSTVSIWAKEESADRTFEMDL---LAIIE 104 Query: 263 GNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREY 308 G+ E G A+S D Y+ T S D +W ET E EY Sbjct: 105 GHENEVK-----GVAWSNDGYYLATCSRDK--SVWIWETDESGEEY 143 Score = 32.3 bits (72), Expect = 0.28, Method: Compositional matrix adjust. Identities = 27/127 (21%), Positives = 51/127 (40%), Gaps = 13/127 (10%) Query: 130 PINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDP--------D 181 I V P+ + L G + IW K + ++ ++I H + D Sbjct: 60 AIRSVAWRPHTSLLAAGSFDSTVSIW-AKEESADRTFEMDLLAIIEGHENEVKGVAWSND 118 Query: 182 ASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSAD 241 Y+A + + ++W T G+E + + + H++ + P LLA+ S D Sbjct: 119 GYYLATCSRDKSVWIWE-TDESGEEYECI---SVLQEHSQDVKHVIWHPSEALLASSSYD 174 Query: 242 QTCKIWR 248 T +IW+ Sbjct: 175 DTVRIWK 181 Score = 30.4 bits (67), Expect = 1.2, Method: Compositional matrix adjust. Identities = 34/175 (19%), Positives = 67/175 (38%), Gaps = 9/175 (5%) Query: 82 DGVNKNIASVGFHEDGRWMYTGGEDCTARIW--DLRSRNLQCQRIFQVNA-PINCVCLHP 138 +G + V + DG ++ T D + IW D +C + Q ++ + V HP Sbjct: 104 EGHENEVKGVAWSNDGYYLATCSRDKSVWIWETDESGEEYECISVLQEHSQDVKHVIWHP 163 Query: 139 NQAELIVGDQSGAIHIWDLKTDHNE--QLIPEPEVSITSAHIDPDASYMAAVNSTGN--C 194 ++A L + IW D E ++ E ++ S+ D + + + Sbjct: 164 SEALLASSSYDDTVRIWKDYDDDWECVAVLNGHEGTVWSSDFDKTEGVFRLCSGSDDSTV 223 Query: 195 YVWNLTGGIGDEVTQLIPKTKIP-AHTRYALQCRFSPDSTLLATCSADQTCKIWR 248 VW G D+ + + + +P H R + + L+A+ AD ++ Sbjct: 224 RVWKYMGDDEDDQQEWVCEAILPDVHKRQVYNVAWGFNG-LIASVGADGVLAVYE 277 Score = 28.9 bits (63), Expect = 3.6, Method: Compositional matrix adjust. Identities = 21/78 (26%), Positives = 30/78 (38%), Gaps = 1/78 (1%) Query: 172 SITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPD 231 +I S P S +AA + +W D ++ I H +S D Sbjct: 60 AIRSVAWRPHTSLLAAGSFDSTVSIWAKEES-ADRTFEMDLLAIIEGHENEVKGVAWSND 118 Query: 232 STLLATCSADQTCKIWRT 249 LATCS D++ IW T Sbjct: 119 GYYLATCSRDKSVWIWET 136 >5K0Y-T nrPDB Length = 329 Score = 38.9 bits (89), Expect = 0.003, Method: Compositional matrix adjust. Identities = 24/88 (27%), Positives = 41/88 (46%), Gaps = 8/88 (9%) Query: 216 IPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWG 275 + H R Q +++ + LL T + D +W + N L G+ G +W Sbjct: 6 LQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVN---GERLGTYMGHTGA-----VWC 57 Query: 276 CAFSGDSQYIVTASSDNLARLWCVETGE 303 D+++++T S+DN RLW ETG+ Sbjct: 58 VDADWDTKHVLTGSADNSCRLWDCETGK 85 Score = 33.1 bits (74), Expect = 0.16, Method: Compositional matrix adjust. Identities = 19/95 (20%), Positives = 43/95 (45%), Gaps = 2/95 (2%) Query: 60 AGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNL 119 AG++ + ++ + +++ ++ I + + T +D TA+++D S L Sbjct: 163 AGHESGELNQYSAKSGEVLVNVKEHSRQINDIQLSREMTMFVTASKDNTAKLFD--STTL 220 Query: 120 QCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHI 154 + Q+ F+ P L PN ++VG A+ + Sbjct: 221 EHQKTFRTEPPRELAALSPNYEHVVVGGGQEAMDV 255 Score = 28.5 bits (62), Expect = 4.4, Method: Compositional matrix adjust. Identities = 13/24 (54%), Positives = 15/24 (62%) Query: 88 IASVGFHEDGRWMYTGGEDCTARI 111 I SV FH DG+ +GGED RI Sbjct: 288 INSVAFHPDGKSYSSGGEDGYVRI 311 >3FM0-A nrPDB Length = 345 Score = 38.9 bits (89), Expect = 0.003, Method: Compositional matrix adjust. Identities = 41/225 (18%), Positives = 88/225 (39%), Gaps = 24/225 (10%) Query: 36 RTVQHQDSQVNALEVTPDRSMIAA-AGYQHIRMYDLNSNN--PNPIISYDGVNKNIASVG 92 R H DS+ L P +++A+ G + IR++ ++ ++S +G + + V Sbjct: 10 RVPAHPDSRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLS-EGHQRTVRKVA 68 Query: 93 FHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNA-PINCVCLHPNQAELIVGDQSGA 151 + G ++ + D T IW + +C + + + V P+ L + + Sbjct: 69 WSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKS 128 Query: 152 IHIWDLKTDHNEQLIPEPEVSITSAHID--------PDASYMAAVNSTGNCYVWNLTGGI 203 + +W++ + + VS+ ++H P +A+ + ++ Sbjct: 129 VWVWEVDEEDEYEC-----VSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYR----- 178 Query: 204 GDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWR 248 +E + + H F P LA+CS D+T +IWR Sbjct: 179 -EEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWR 222 Score = 38.1 bits (87), Expect = 0.006, Method: Compositional matrix adjust. Identities = 47/232 (20%), Positives = 85/232 (36%), Gaps = 24/232 (10%) Query: 91 VGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQV--NAPINCVCLHPNQAELIVGDQ 148 + ++ G + + G D RIW + C+ + + V P L Sbjct: 22 LAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASF 81 Query: 149 SGAIHIWDLKTDHNEQL--IPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDE 206 IW D E + + E + S P + +A + + +VW + DE Sbjct: 82 DATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEV-----DE 136 Query: 207 VTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPG 266 + + + +HT+ + P LLA+ S D T K++R + ++ Sbjct: 137 EDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATL------ 190 Query: 267 ESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREY-GGHQKAVVC 317 E +W AF Q + + S D R+W R+Y G+++ V C Sbjct: 191 EGHESTVWSLAFDPSGQRLASCSDDRTVRIW--------RQYLPGNEQGVAC 234 Score = 33.5 bits (75), Expect = 0.14, Method: Compositional matrix adjust. Identities = 34/125 (27%), Positives = 54/125 (43%), Gaps = 24/125 (19%) Query: 210 LIPKTKIPAHTRYALQCRF---SPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPG 266 L+ ++PAH +C F +P TLLA+C D+ +IW T S + + + G+ Sbjct: 5 LVLLGRVPAHPDS--RCWFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQR 62 Query: 267 ESSRGWMWGCAFSGDSQYIVTASSDNLARLW--------CVETGEIKREYGGHQKAVVCL 318 + A+S Y+ +AS D +W CV T E GH+ V + Sbjct: 63 TVRK-----VAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLE------GHENEVKSV 111 Query: 319 AFNDS 323 A+ S Sbjct: 112 AWAPS 116 Score = 27.3 bits (59), Expect = 8.6, Method: Compositional matrix adjust. Identities = 14/48 (29%), Positives = 26/48 (54%), Gaps = 2/48 (4%) Query: 14 ILATAGYDHTVRFWQAHSG--ICTRTVQHQDSQVNALEVTPDRSMIAA 59 +LA+A YD TV+ ++ +C T++ +S V +L P +A+ Sbjct: 164 LLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQRLAS 211 >4XFV-A nrPDB Length = 792 Score = 38.5 bits (88), Expect = 0.004, Method: Compositional matrix adjust. Identities = 46/224 (20%), Positives = 88/224 (39%), Gaps = 21/224 (9%) Query: 42 DSQVNALEVTPDRSMIAAAGYQHIRMYD-LNSNNPNPIISYDGVNKNIASVGFHEDGRWM 100 + Q ++ + ++A + I ++D + NN + G + V F D +M Sbjct: 19 NKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFM 78 Query: 101 YTGGEDCTARIWDLRS-RNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKT 159 + ED +IW +LQC + Q + V L + + VG G I IW + Sbjct: 79 VSASEDHHVKIWKFTDYSHLQCIQTIQ-HYSKTIVALSALPSLISVGCADGTISIWR-QN 136 Query: 160 DHNEQLIPEPEVSITSAHIDP---------DASYMAAVNSTG-NCYVWN-LTGGIGDEVT 208 N++ E +I P + Y+ A+ T N ++ + + G E Sbjct: 137 IQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKC 196 Query: 209 QLIPKTKIPAHTRYALQCRF----SPDSTLLATCSADQTCKIWR 248 +++ ++ H + F +P LL + S D+ ++WR Sbjct: 197 RVV--AELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWR 238 Score = 36.2 bits (82), Expect = 0.022, Method: Compositional matrix adjust. Identities = 45/176 (25%), Positives = 65/176 (36%), Gaps = 23/176 (13%) Query: 165 LIPEPE------VSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPA 218 L PE E IT I PD +A+ + N V N I L K +P Sbjct: 551 LWPEVEKLYGHGFEITCLDISPDQKLIASACRSNN--VQNAVIRIFSTENWLEIKPALPF 608 Query: 219 HTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAF 278 H+ + +FS D L + D+ +W + EL K+ P + W A Sbjct: 609 HSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKP-HTRIIWDADWAP 667 Query: 279 SGDSQYIVTASSDNLARLW---------CVETGEIKREYGGHQKAVVCLAFNDSVL 325 VTAS D ++W V IK H KAV ++ +DS++ Sbjct: 668 LEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIK-----HTKAVTAISIHDSMI 718 Score = 30.8 bits (68), Expect = 0.79, Method: Compositional matrix adjust. Identities = 11/28 (39%), Positives = 17/28 (60%) Query: 226 CRFSPDSTLLATCSADQTCKIWRTSNFS 253 RF PDS + + S D KIW+ +++S Sbjct: 69 VRFVPDSDFMVSASEDHHVKIWKFTDYS 96 >4OWR-A nrPDB Length = 339 Score = 38.5 bits (88), Expect = 0.004, Method: Compositional matrix adjust. Identities = 23/85 (27%), Positives = 43/85 (50%), Gaps = 4/85 (4%) Query: 88 IASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCV--CLHPNQAELIV 145 + V + +DG ++T D TA++WDL S Q +I Q +AP+ + PN + ++ Sbjct: 60 VLDVCWSDDGSKVFTASCDKTAKMWDLSSN--QAIQIAQHDAPVKTIHWIKAPNYSCVMT 117 Query: 146 GDQSGAIHIWDLKTDHNEQLIPEPE 170 G + WD ++ + ++ PE Sbjct: 118 GSWDKTLKFWDTRSSNPMMVLQLPE 142 >5WLC-LS nrPDB Length = 594 Score = 38.1 bits (87), Expect = 0.005, Method: Compositional matrix adjust. Identities = 32/139 (23%), Positives = 60/139 (43%), Gaps = 21/139 (15%) Query: 29 AHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNI 88 A + I + T ++D+ N+ + P + I +R+ D N+++P+ + I Sbjct: 207 ALTKILSTTYNYKDTLSNSKLLPPKKLDI-------VRLKDANASHPS--------HSAI 251 Query: 89 ASVGFHEDGRWMYTGGEDCTARIWDLRSR-NLQCQRIFQVNAPINCVCLHP-----NQAE 142 S+ FH + TGG D T RI+ + + N + V +PI + NQ Sbjct: 252 QSLSFHPSKPLLLTGGYDKTLRIYHIDGKTNHLVTSLHLVGSPIQTCTFYTSLSNQNQQN 311 Query: 143 LIVGDQSGAIHIWDLKTDH 161 + + +H WDL ++ Sbjct: 312 IFTAGRRRYMHSWDLSLEN 330 Score = 35.4 bits (80), Expect = 0.036, Method: Compositional matrix adjust. Identities = 36/157 (22%), Positives = 67/157 (42%), Gaps = 28/157 (17%) Query: 22 HTVRFWQAHSGICTRTVQ---HQDSQVNALEVTP---DRSMIAAAGYQHIRMYDLN---- 71 H +R W+ G+ +Q + AL+++ +R + + + +YD N Sbjct: 442 HVIRRWKDQGGVGITKIQVGGGTTTTCPALQISKIKQNRWLAVGSESGFVNLYDRNNAMT 501 Query: 72 SNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTAR--IWD-LRSRNLQCQRIFQVN 128 S+ P P+ + D + I+++ F DG+ + C A + D LR +L +F N Sbjct: 502 SSTPTPVAALDQLTTTISNLQFSPDGQIL------CMASRAVKDALRLVHLPSCSVFS-N 554 Query: 129 AP--------INCVCLHPNQAELIVGDQSGAIHIWDL 157 P + V P+ L VG++ G + +W L Sbjct: 555 WPTSGTPLGKVTSVAFSPSGGLLAVGNEQGKVRLWKL 591 >5WLC-LU nrPDB Length = 489 Score = 37.4 bits (85), Expect = 0.009, Method: Compositional matrix adjust. Identities = 52/247 (21%), Positives = 92/247 (37%), Gaps = 74/247 (29%) Query: 59 AAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHE-DGRWMYTGGEDCTARIWDLRSR 117 A G I ++D+N P +S+ NI S+ F++ + + + G D + ++DLR+ Sbjct: 195 ATGGAKIHLWDVNRLKPVSDLSWGA--DNITSLKFNQNETDILASTGSDNSIVLYDLRT- 251 Query: 118 NLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAH 177 N Q+I Q N +C +P +A + +A+ Sbjct: 252 NSPTQKIVQT-MRTNAICWNPMEA-----------------------------FNFVTAN 281 Query: 178 IDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLAT 237 D +A Y N + + V+ H + FSP + T Sbjct: 282 EDHNAYYYDMRNLSRSLNVF-------------------KDHVSAVMDVDFSPTGDEIVT 322 Query: 238 CSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGW-------MWGCAFSGDSQYIVTASS 290 S D++ +I++T N G S + ++ +S DS+YI++ S Sbjct: 323 GSYDKSIRIYKT--------------NHGHSREIYHTKRMQHVFQVKYSMDSKYIISGSD 368 Query: 291 DNLARLW 297 D RLW Sbjct: 369 DGNVRLW 375 >4J0W-A nrPDB Length = 343 Score = 36.6 bits (83), Expect = 0.015, Method: Compositional matrix adjust. Identities = 34/155 (21%), Positives = 57/155 (36%), Gaps = 17/155 (10%) Query: 170 EVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKI------PAHTRYA 223 ++SIT + PD S + + + W++ G +IP+ K P H+ + Sbjct: 14 QLSITCLVVTPDDSAIFSAAKDCSIIKWSVESG---RKLHVIPRAKKGAEGKPPGHSSHV 70 Query: 224 LQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQ 283 L S D LA+ + IW + + + R + G AF + Sbjct: 71 LCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFT--------GHRDAVSGLAFRRGTH 122 Query: 284 YIVTASSDNLARLWCVETGEIKREYGGHQKAVVCL 318 + + S D ++W V GHQ AV L Sbjct: 123 QLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAAL 157 Score = 31.2 bits (69), Expect = 0.70, Method: Compositional matrix adjust. Identities = 47/278 (16%), Positives = 101/278 (36%), Gaps = 30/278 (10%) Query: 36 RTVQHQDSQVNALEVTPDRSMIAAAGYQ-HIRMYDLNSNNPNPIISY---------DGVN 85 R ++ + L VTPD S I +A I + + S +I G + Sbjct: 8 RVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHS 67 Query: 86 KNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNA---PINCVCLHPNQAE 142 ++ + DG+++ +G IW+ +S CQ ++ ++ + + Sbjct: 68 SHVLCMAISSDGKYLASGDRSKLILIWEAQS----CQHLYTFTGHRDAVSGLAFRRGTHQ 123 Query: 143 LIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGG 202 L ++ +W++ + + + + ++ + + A G VW + Sbjct: 124 LYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIP-- 181 Query: 203 IGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSN---FSLMTELS 259 E +QL+ H + ++ C + + + + D + +W S +L E Sbjct: 182 ---EESQLV----FYGH-QGSIDCIHLINEEHMVSGADDGSVALWGLSKKRPLALQREAH 233 Query: 260 IKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLW 297 G PG W+ A ++ + T S + RLW Sbjct: 234 GLRGEPGLEQPFWISSVAALLNTDLVATGSHSSCVRLW 271 Score = 28.9 bits (63), Expect = 3.3, Method: Compositional matrix adjust. Identities = 25/98 (25%), Positives = 41/98 (41%), Gaps = 7/98 (7%) Query: 229 SPDSTLLATCSADQTCKIWRT-SNFSLMTELSIKSGN----PGESSRGWMWGCAFSGDSQ 283 +PD + + + + D + W S L K G PG SS + A S D + Sbjct: 23 TPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSH--VLCMAISSDGK 80 Query: 284 YIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFN 321 Y+ + L +W ++ + + GH+ AV LAF Sbjct: 81 YLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFR 118 >5OQL-d nrPDB Length = 446 Score = 36.2 bits (82), Expect = 0.018, Method: Compositional matrix adjust. Identities = 74/328 (22%), Positives = 132/328 (40%), Gaps = 47/328 (14%) Query: 15 LATAGYDHTVRFWQAHSGICTR-----TVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYD 69 +A+ D V+ W + TR V ++ V L T D+ +++ A I+++D Sbjct: 82 IASGSGDGVVKVWD----LTTRDEETWRVAAHNNIVKGLTFTNDKKLLSCAT-DGIKLWD 136 Query: 70 --LNSNNPNPIISYDGVNKNIASVGFHEDGR-WMYTGGEDCTARIWDLR-SRNLQCQRIF 125 + +N PI ++ S+ FH + + G+ C RIWDL S Q + Sbjct: 137 PYASPSNTTPIATWQE-GGPYTSLSFHRSANTFAASSGQGCI-RIWDLEHSTAGQAIQWP 194 Query: 126 QVNAPINCVCLHPNQAEL-IVGDQSG--AIHIWDLKTDHNEQLIPEPEVSITSA----HI 178 I VC NQ E ++G + +I ++DL+T+ +P + + A Sbjct: 195 SFVDTITDVCF--NQVETSVIGSVATDRSIILFDLRTN-----MPVIKTVLHFACNRIVF 247 Query: 179 DP-DASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLAT 237 +P +A +A + N Y+++ D+ + H + FSP L + Sbjct: 248 NPMEAMNLAVASEDHNIYIFDARNF--DKALNIQK-----GHVAAVMDVEFSPTGEELVS 300 Query: 238 CSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLW 297 S D+T ++WR K ++ ++ DS+YI+T S D RLW Sbjct: 301 GSYDRTIRLWRRDAGHSRDVYHTKRMQR-------VFRTMWTMDSKYILTGSDDGNVRLW 353 Query: 298 CVETGEIKREYGGHQKAVVCLAFNDSVL 325 E Q+ L +N+++L Sbjct: 354 RANASERSGVKATRQRQ--ALEYNNALL 379 >6CHG-A nrPDB Length = 312 Score = 36.2 bits (82), Expect = 0.021, Method: Compositional matrix adjust. Identities = 43/192 (22%), Positives = 75/192 (39%), Gaps = 32/192 (16%) Query: 11 DPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDL 70 D IL++ YD +R + SG C +T +T D+ IA G I Sbjct: 149 DSSILSSGSYDGLIRIFDTESGHCLKT------------LTYDKDWIAEDGVVPISTVKF 196 Query: 71 NSNNPNPII-SYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNA 129 + N ++ S D V K W YT G +W + + + N Sbjct: 197 SRNGKFLLVKSLDNVVK-----------LWEYTRGTVVRTFLWPHQETKAK----LKYNC 241 Query: 130 PINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASY--MAA 187 + + +I G+ SG++ +W++ + + Q I E + S I ASY +A Sbjct: 242 GLELIYPQGKDPLVISGNDSGSMCVWNVYSKNLVQKIDEKHRN--SPLISISASYDKVAT 299 Query: 188 VNSTGNCYVWNL 199 ++ G C ++ + Sbjct: 300 LSLNGECNLFRV 311 Score = 32.0 bits (71), Expect = 0.37, Method: Compositional matrix adjust. Identities = 22/92 (23%), Positives = 43/92 (46%), Gaps = 1/92 (1%) Query: 231 DSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASS 290 DS++L++ S D +I+ T + + L+ E + FS + ++++ S Sbjct: 149 DSSILSSGSYDGLIRIFDTESGHCLKTLTYDKDWIAEDGVVPISTVKFSRNGKFLLVKSL 208 Query: 291 DNLARLWCVETGEIKREYG-GHQKAVVCLAFN 321 DN+ +LW G + R + HQ+ L +N Sbjct: 209 DNVVKLWEYTRGTVVRTFLWPHQETKAKLKYN 240 Score = 31.6 bits (70), Expect = 0.52, Method: Compositional matrix adjust. Identities = 27/111 (24%), Positives = 46/111 (41%), Gaps = 12/111 (10%) Query: 213 KTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGW 272 K +PA + + C+ SPD L+A C L+ E+S ++ Sbjct: 6 KQVLPASGKISTSCQISPDGELIAICQNTDM----------LVYEISSSKMMKLTTTHKE 55 Query: 273 MWGC-AFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFND 322 C +S DS+ I + S D + + G I+R GH V+ + +N+ Sbjct: 56 CINCLCWSPDSKCIASGSEDFTVEITHIIYGRIRR-LMGHTAPVISICYNN 105 >6QDV-o nrPDB Length = 513 Score = 36.2 bits (82), Expect = 0.021, Method: Compositional matrix adjust. Identities = 44/241 (18%), Positives = 97/241 (40%), Gaps = 17/241 (7%) Query: 15 LATAGYDHTVRFWQAHSGIC-TRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLNSN 73 +A YD ++ W +G C +R + D+ + AG ++ + Sbjct: 281 FLSAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPDEDKQNLFVAGMSDKKIVQWDIR 340 Query: 74 NPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNA-PIN 132 + + YD + ++ F ++ R + +D + R+W+ + + I + + + Sbjct: 341 SGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEW-DIPVDFKYIAEPSMHSMP 399 Query: 133 CVCLHPNQAELIVGDQSGAIHIWDLKTD---HNEQLIPEPEVSITSAHID--PDASYMAA 187 V L PN L I I+ + + +++ V+ + +D PD SY+ + Sbjct: 400 AVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFSPDMSYVIS 459 Query: 188 VNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSP-DSTLLATCSADQTCKI 246 + G +W+ + T+L + K AH + + + P +++ + TC D K+ Sbjct: 460 GDGNGKLNIWDW------KTTKLYSRFK--AHDKVCIGAVWHPHETSKVITCGWDGLIKL 511 Query: 247 W 247 W Sbjct: 512 W 512 Score = 35.0 bits (79), Expect = 0.043, Method: Compositional matrix adjust. Identities = 47/247 (19%), Positives = 94/247 (38%), Gaps = 25/247 (10%) Query: 80 SYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPN 139 ++ G +K + + F+ G + D ++WD + QC F CV +P+ Sbjct: 261 TFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWD--TETGQCISRFTNRKVPYCVKFNPD 318 Query: 140 QAE---LIVGDQSGAIHIWDLKTDHNEQLIPEPEVSI----TSAHIDPDASYMAAVNSTG 192 + + + G I WD+++ +++ E + + T +D + +++ + Sbjct: 319 EDKQNLFVAGMSDKKIVQWDIRSG---EIVQEYDRHLGAVNTIVFVDENRRFVSTSDDK- 374 Query: 193 NCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNF 252 + VW + + +PA T SP+ LA S D I+ N Sbjct: 375 SLRVWEWDIPVDFKYIAEPSMHSMPAVT-------LSPNGKWLACQSMDNQILIFGAQN- 426 Query: 253 SLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQ 312 L+ K G G+ FS D Y+++ + +W +T ++ + H Sbjct: 427 --RFRLNKKKIFKGHMVAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHD 484 Query: 313 KAVVCLA 319 K VC+ Sbjct: 485 K--VCIG 489 Score = 29.6 bits (65), Expect = 1.6, Method: Compositional matrix adjust. Identities = 24/109 (22%), Positives = 41/109 (37%), Gaps = 12/109 (11%) Query: 218 AHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCA 277 H++ F+ T + + D+ K+W T ++ + +R + Sbjct: 264 GHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFT---------NRKVPYCVK 314 Query: 278 FSGDS---QYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDS 323 F+ D V SD W + +GEI +EY H AV + F D Sbjct: 315 FNPDEDKQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDE 363 >5YZG-2 nrPDB Length = 646 Score = 35.8 bits (81), Expect = 0.029, Method: Compositional matrix adjust. Identities = 49/223 (21%), Positives = 91/223 (40%), Gaps = 47/223 (21%) Query: 14 ILATAGYDHTVRFWQA-HSGICTRTVQHQDSQVNALE---VTPDRSMIAAAGY-QHIRMY 68 + TA +D V+FW+ GI V+H S + +E V+ + ++ + G + ++++ Sbjct: 103 FIITASHDGHVKFWKKIEEGI--EFVKHFRSHLGVIESIAVSSEGALFCSVGDDKAMKVF 160 Query: 69 DLNSNNPNPIISYDGVNKNIASVG-FHEDGRWMYTGG---------EDCTARI--WDLRS 116 D ++++D +N + +G F W+Y G E T +I +D R Sbjct: 161 D--------VVNFDMIN--MLKLGYFPGQCEWIYCPGDAISSVAASEKSTGKIFIYDGRG 210 Query: 117 RNLQCQRIFQV--NAPINCVCLHPNQAELIVGDQSGAIHI---------------WDLKT 159 N Q IF +P+ + L+P ++ D+SG I W+ KT Sbjct: 211 DN-QPLHIFDKLHTSPLTQIRLNPVYKAVVSSDKSGMIEYWTGPPHEYKFPKNVNWEYKT 269 Query: 160 DHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGG 202 D + + + TS PD +A + S ++ G Sbjct: 270 DTDLYEFAKCKAYPTSVCFSPDGKKIATIGSDRKVRIFRFVTG 312 >5YZG-W nrPDB Length = 579 Score = 35.4 bits (80), Expect = 0.030, Method: Compositional matrix adjust. Identities = 44/241 (18%), Positives = 97/241 (40%), Gaps = 17/241 (7%) Query: 15 LATAGYDHTVRFWQAHSGIC-TRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLNSN 73 +A YD ++ W +G C +R + D+ + AG ++ + Sbjct: 347 FLSAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPDEDKQNLFVAGMSDKKIVQWDIR 406 Query: 74 NPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNA-PIN 132 + + YD + ++ F ++ R + +D + R+W+ + + I + + + Sbjct: 407 SGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEW-DIPVDFKYIAEPSMHSMP 465 Query: 133 CVCLHPNQAELIVGDQSGAIHIWDLKTD---HNEQLIPEPEVSITSAHID--PDASYMAA 187 V L PN L I I+ + + +++ V+ + +D PD SY+ + Sbjct: 466 AVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFSPDMSYVIS 525 Query: 188 VNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSP-DSTLLATCSADQTCKI 246 + G +W+ + T+L + K AH + + + P +++ + TC D K+ Sbjct: 526 GDGNGKLNIWDW------KTTKLYSRFK--AHDKVCIGAVWHPHETSKVITCGWDGLIKL 577 Query: 247 W 247 W Sbjct: 578 W 578 Score = 35.0 bits (79), Expect = 0.049, Method: Compositional matrix adjust. Identities = 46/247 (18%), Positives = 95/247 (38%), Gaps = 25/247 (10%) Query: 80 SYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPN 139 ++ G +K + + F+ G + D ++WD + QC F CV +P+ Sbjct: 327 TFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWD--TETGQCISRFTNRKVPYCVKFNPD 384 Query: 140 QAE---LIVGDQSGAIHIWDLKTDHNEQLIPEPEVSI----TSAHIDPDASYMAAVNSTG 192 + + + G I WD+++ +++ E + + T +D + +++ + Sbjct: 385 EDKQNLFVAGMSDKKIVQWDIRSG---EIVQEYDRHLGAVNTIVFVDENRRFVSTSDDK- 440 Query: 193 NCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNF 252 + VW + + +PA T SP+ LA S D I+ N Sbjct: 441 SLRVWEWDIPVDFKYIAEPSMHSMPAVT-------LSPNGKWLACQSMDNQILIFGAQNR 493 Query: 253 SLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQ 312 + + I G+ G+ FS D Y+++ + +W +T ++ + H Sbjct: 494 FRLNKKKIFKGH---MVAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHD 550 Query: 313 KAVVCLA 319 K VC+ Sbjct: 551 K--VCIG 555 Score = 29.6 bits (65), Expect = 1.6, Method: Compositional matrix adjust. Identities = 24/109 (22%), Positives = 41/109 (37%), Gaps = 12/109 (11%) Query: 218 AHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCA 277 H++ F+ T + + D+ K+W T ++ + +R + Sbjct: 330 GHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFT---------NRKVPYCVK 380 Query: 278 FSGDS---QYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDS 323 F+ D V SD W + +GEI +EY H AV + F D Sbjct: 381 FNPDEDKQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDE 429 >5LCW-Q nrPDB Length = 374 Score = 35.0 bits (79), Expect = 0.044, Method: Compositional matrix adjust. Identities = 48/250 (19%), Positives = 92/250 (36%), Gaps = 35/250 (14%) Query: 15 LATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQ--HIRMYDLNS 72 LA V+ W R + ++V +L S I ++G + HI +D+ Sbjct: 116 LAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWN---SYILSSGSRSGHIHHHDVRV 172 Query: 73 NNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRN---LQCQRIFQVNA 129 + + + G ++ + + + DGR + +GG D +W + Q Q Sbjct: 173 AEHH-VATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQG 231 Query: 130 PINCVCLHPNQAELIV---GDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMA 186 + V P Q+ ++ G I IW++ + A + ++ Sbjct: 232 AVKAVAWCPWQSNVLATGGGTSDRHIRIWNV---------------CSGACLSAVDAHSQ 276 Query: 187 AVNSTGNCYVWNLTGGIGDEVTQLI--------PKTKIPAHTRYALQCRFSPDSTLLATC 238 + + + L G G QL+ ++ HT L SPD +A+ Sbjct: 277 VCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASA 336 Query: 239 SADQTCKIWR 248 +AD+T ++WR Sbjct: 337 AADETLRLWR 346 Score = 31.6 bits (70), Expect = 0.54, Method: Compositional matrix adjust. Identities = 25/102 (24%), Positives = 42/102 (41%), Gaps = 4/102 (3%) Query: 14 ILATAG--YDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPD-RSMIAAAGYQHIRMYDL 70 +LAT G D +R W SG C V SQV ++ +P + +I+ G+ ++ Sbjct: 245 VLATGGGTSDRHIRIWNVCSGACLSAVD-AHSQVCSILWSPHYKELISGHGFAQNQLVIW 303 Query: 71 NSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIW 112 + G + S+ DG + + D T R+W Sbjct: 304 KYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 345 >4N14-A nrPDB Length = 314 Score = 35.0 bits (79), Expect = 0.044, Method: Compositional matrix adjust. Identities = 47/246 (19%), Positives = 92/246 (37%), Gaps = 27/246 (10%) Query: 15 LATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQ--HIRMYDLNS 72 LA V+ W R + ++V +L S I ++G + HI +D+ Sbjct: 78 LAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWN---SYILSSGSRSGHIHHHDVRV 134 Query: 73 NNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRN---LQCQRIFQVNA 129 + + + G ++ + + + DGR + +GG D +W + Q Q Sbjct: 135 AEHH-VATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQG 193 Query: 130 PINCVCLHPNQAELIV---GDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMA 186 + V P Q+ ++ G I IW++ + + + + S P Y Sbjct: 194 AVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAV-DAHSQVCSILWSPH--YKE 250 Query: 187 AVNSTG----NCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQ 242 ++ G +W + + ++ HT L SPD +A+ +AD+ Sbjct: 251 LISGHGFAQNQLVIW--------KYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADE 302 Query: 243 TCKIWR 248 T ++WR Sbjct: 303 TLRLWR 308 Score = 31.6 bits (70), Expect = 0.46, Method: Compositional matrix adjust. Identities = 25/102 (24%), Positives = 42/102 (41%), Gaps = 4/102 (3%) Query: 14 ILATAG--YDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPD-RSMIAAAGYQHIRMYDL 70 +LAT G D +R W SG C V SQV ++ +P + +I+ G+ ++ Sbjct: 207 VLATGGGTSDRHIRIWNVCSGACLSAVD-AHSQVCSILWSPHYKELISGHGFAQNQLVIW 265 Query: 71 NSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIW 112 + G + S+ DG + + D T R+W Sbjct: 266 KYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 307 >4GGA-A nrPDB Length = 420 Score = 35.0 bits (79), Expect = 0.044, Method: Compositional matrix adjust. Identities = 48/250 (19%), Positives = 92/250 (36%), Gaps = 35/250 (14%) Query: 15 LATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQ--HIRMYDLNS 72 LA V+ W R + ++V +L S I ++G + HI +D+ Sbjct: 162 LAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWN---SYILSSGSRSGHIHHHDVRV 218 Query: 73 NNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRN---LQCQRIFQVNA 129 + + + G ++ + + + DGR + +GG D +W + Q Q Sbjct: 219 AEHH-VATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQG 277 Query: 130 PINCVCLHPNQAELIV---GDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMA 186 + V P Q+ ++ G I IW++ + A + ++ Sbjct: 278 AVKAVAWCPWQSNVLATGGGTSDRHIRIWNV---------------CSGACLSAVDAHSQ 322 Query: 187 AVNSTGNCYVWNLTGGIGDEVTQLI--------PKTKIPAHTRYALQCRFSPDSTLLATC 238 + + + L G G QL+ ++ HT L SPD +A+ Sbjct: 323 VCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASA 382 Query: 239 SADQTCKIWR 248 +AD+T ++WR Sbjct: 383 AADETLRLWR 392 Score = 31.2 bits (69), Expect = 0.60, Method: Compositional matrix adjust. Identities = 25/102 (24%), Positives = 42/102 (41%), Gaps = 4/102 (3%) Query: 14 ILATAG--YDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPD-RSMIAAAGYQHIRMYDL 70 +LAT G D +R W SG C V SQV ++ +P + +I+ G+ ++ Sbjct: 291 VLATGGGTSDRHIRIWNVCSGACLSAVD-AHSQVCSILWSPHYKELISGHGFAQNQLVIW 349 Query: 71 NSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIW 112 + G + S+ DG + + D T R+W Sbjct: 350 KYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 391 >4G56-B nrPDB Length = 357 Score = 35.0 bits (79), Expect = 0.050, Method: Compositional matrix adjust. Identities = 28/145 (19%), Positives = 64/145 (44%), Gaps = 14/145 (9%) Query: 33 ICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLNSNNP---NPIISYDGVNKNIA 89 +CT VQ ++ V + ++ ++ A+ + ++++ N Y+ + + Sbjct: 86 LCTAGVQ-TEAGVTDVAWVSEKGILVASDSGAVELWEILEKESLLVNKFAKYEH-DDIVK 143 Query: 90 SVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVG-DQ 148 ++ DG +GG+D + ++WDL S+ + ++ +NCV P + + + + Sbjct: 144 TLSVFSDGTQAVSGGKDFSVKVWDL-SQKAVLKSYNAHSSEVNCVAACPGKDTIFLSCGE 202 Query: 149 SGAIHIWDLKTDHNEQLIPEPEVSI 173 G I +WD + P+P I Sbjct: 203 DGRILLWDTRK-------PKPATRI 220 >5G04-R nrPDB Length = 499 Score = 34.7 bits (78), Expect = 0.064, Method: Compositional matrix adjust. Identities = 48/250 (19%), Positives = 92/250 (36%), Gaps = 35/250 (14%) Query: 15 LATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQ--HIRMYDLNS 72 LA V+ W R + ++V +L S I ++G + HI +D+ Sbjct: 241 LAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWN---SYILSSGSRSGHIHHHDVRV 297 Query: 73 NNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRN---LQCQRIFQVNA 129 + + + G ++ + + + DGR + +GG D +W + Q Q Sbjct: 298 AEHH-VATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQG 356 Query: 130 PINCVCLHPNQAELIV---GDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMA 186 + V P Q+ ++ G I IW++ + A + ++ Sbjct: 357 AVKAVAWCPWQSNVLATGGGTSDRHIRIWNV---------------CSGACLSAVDAHSQ 401 Query: 187 AVNSTGNCYVWNLTGGIGDEVTQLI--------PKTKIPAHTRYALQCRFSPDSTLLATC 238 + + + L G G QL+ ++ HT L SPD +A+ Sbjct: 402 VCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASA 461 Query: 239 SADQTCKIWR 248 +AD+T ++WR Sbjct: 462 AADETLRLWR 471 Score = 30.8 bits (68), Expect = 0.76, Method: Compositional matrix adjust. Identities = 25/102 (24%), Positives = 42/102 (41%), Gaps = 4/102 (3%) Query: 14 ILATAG--YDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPD-RSMIAAAGYQHIRMYDL 70 +LAT G D +R W SG C V SQV ++ +P + +I+ G+ ++ Sbjct: 370 VLATGGGTSDRHIRIWNVCSGACLSAVDAH-SQVCSILWSPHYKELISGHGFAQNQLVIW 428 Query: 71 NSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIW 112 + G + S+ DG + + D T R+W Sbjct: 429 KYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470 >5WLC-LJ nrPDB Length = 513 Score = 34.3 bits (77), Expect = 0.067, Method: Compositional matrix adjust. Identities = 40/156 (25%), Positives = 62/156 (39%), Gaps = 16/156 (10%) Query: 11 DPVILATAGYDHTVRFWQAHSGICTR-TVQHQDSQVNALEVTPDRSMIAAAGYQH--IRM 67 D ILATA D R W + + + V L P + A G IR+ Sbjct: 136 DNKILATASDDRVTRLWDISNAYEPQLELTGATDYVRTLSFIPAAPHLVATGSYDGLIRL 195 Query: 68 YDLNSNNPNPIIS--YDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIF 125 YD S+ PI S +D +N+ +V + + GG + ++WDL S +R Sbjct: 196 YDTRSSGSTPIYSLNHDQPVENVIAVS---PTQIVSCGGNNF--KVWDLTSNKKLYER-G 249 Query: 126 QVNAPINCVCL-----HPNQAELIVGDQSGAIHIWD 156 N + C+ P Q+ LI G + ++D Sbjct: 250 NFNKAVTCLDYVENFDSPMQSALIASSLDGHVKVFD 285 >5CXB-B nrPDB Length = 369 Score = 34.3 bits (77), Expect = 0.070, Method: Compositional matrix adjust. Identities = 29/92 (31%), Positives = 48/92 (52%), Gaps = 7/92 (7%) Query: 7 TVGSDP--VILATAGYDHTVRFWQAHSGICTRTVQ-HQDSQVNALEVTP--DRSMIAAAG 61 +V DP V LAT G D TVR W+ +G +V+ + D VN + P D ++AAA Sbjct: 26 SVAIDPTGVALATGGDDGTVRVWELLTGRQVWSVKLNGDEAVNTVRWRPTKDTFILAAAA 85 Query: 62 YQHIRMYDLNSNNPNPIISYDGVNKNIASVGF 93 + I + + +P+ + D +++I + GF Sbjct: 86 GEDI--FLMIPTHPSVTPALDQASRDILNAGF 115 Score = 30.8 bits (68), Expect = 0.89, Method: Compositional matrix adjust. Identities = 19/80 (23%), Positives = 32/80 (40%), Gaps = 3/80 (3%) Query: 74 NPNPIIS---YDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAP 130 P P + + G + SV G + TGG+D T R+W+L + + Sbjct: 7 KPFPTVQQTIFRGHEGRVRSVAIDPTGVALATGGDDGTVRVWELLTGRQVWSVKLNGDEA 66 Query: 131 INCVCLHPNQAELIVGDQSG 150 +N V P + I+ +G Sbjct: 67 VNTVRWRPTKDTFILAAAAG 86 >6BX3-B nrPDB Length = 412 Score = 33.9 bits (76), Expect = 0.11, Method: Compositional matrix adjust. Identities = 27/99 (27%), Positives = 40/99 (40%), Gaps = 21/99 (21%) Query: 211 IPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSR 270 +P + AH R +SPD LL T S D + K+W S S + I+ +P Sbjct: 62 VPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLK-EIRFDSP----- 115 Query: 271 GWMWGCA-------------FSGDSQYIVTASSDNLARL 296 +WGC F Y++ S+D +A L Sbjct: 116 --IWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASL 152 Score = 28.9 bits (63), Expect = 3.2, Method: Compositional matrix adjust. Identities = 13/46 (28%), Positives = 25/46 (54%), Gaps = 1/46 (2%) Query: 86 KNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPI 131 + I S+ + DGR + T D + ++WDL + + I + ++PI Sbjct: 72 RPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEI-RFDSPI 116 >3C9C-A nrPDB Length = 432 Score = 33.5 bits (75), Expect = 0.14, Method: Compositional matrix adjust. Identities = 38/181 (20%), Positives = 69/181 (38%), Gaps = 18/181 (9%) Query: 58 AAAGYQHIRMYDLNSNN-PNPIISYDGVNKNIASVGFHEDGRWMY-TGGEDCTARIWDLR 115 + A Q + ++D +NN P + D + + F+ ++ TG D T +WDLR Sbjct: 251 SVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLR 310 Query: 116 SRNLQCQRIFQVNAPINCVCLHP-NQAELIVGDQSGAIHIWDLKTDHNEQLIPEPE---- 170 + L+ I V P N+ L +H+WDL EQ + E Sbjct: 311 NLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPP 370 Query: 171 ----------VSITSAHIDPDASYMAAVNSTGNCY-VWNLTGGIGDEVTQLIPKTKIPAH 219 I+ +P+ ++ S N VW + + ++ IP +++ + Sbjct: 371 ELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENVYNDEEPEIPASELETN 430 Query: 220 T 220 T Sbjct: 431 T 431 Score = 29.6 bits (65), Expect = 1.9, Method: Compositional matrix adjust. Identities = 21/67 (31%), Positives = 29/67 (43%), Gaps = 11/67 (16%) Query: 199 LTGGIGDEVTQLI----------PKTKIPAHTRYALQCRFSPDST-LLATCSADQTCKIW 247 L G + D+ +I P + AHT F+P S +LAT SAD+T +W Sbjct: 248 LFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALW 307 Query: 248 RTSNFSL 254 N L Sbjct: 308 DLRNLKL 314 >5Y1U-A nrPDB Length = 456 Score = 32.7 bits (73), Expect = 0.21, Method: Compositional matrix adjust. Identities = 29/110 (26%), Positives = 45/110 (40%), Gaps = 3/110 (2%) Query: 58 AAAGYQHIRMYDLNSNN-PNPIISYDGVNKNIASVGFHEDGRWMY-TGGEDCTARIWDLR 115 + A Q + ++D SNN P S D + + F+ ++ TG D T +WDLR Sbjct: 276 SVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLR 335 Query: 116 SRNLQCQRIFQVNAPINCVCLHP-NQAELIVGDQSGAIHIWDLKTDHNEQ 164 + L+ I V P N+ L +++WDL EQ Sbjct: 336 NLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQ 385 Score = 29.6 bits (65), Expect = 1.6, Method: Compositional matrix adjust. Identities = 21/68 (30%), Positives = 30/68 (44%), Gaps = 11/68 (16%) Query: 198 NLTGGIGDEVTQLI----------PKTKIPAHTRYALQCRFSPDST-LLATCSADQTCKI 246 +L G + D+ +I P + AHT F+P S +LAT SAD+T + Sbjct: 272 SLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVAL 331 Query: 247 WRTSNFSL 254 W N L Sbjct: 332 WDLRNLKL 339 >5L9T-R nrPDB Length = 493 Score = 32.7 bits (73), Expect = 0.25, Method: Compositional matrix adjust. Identities = 46/252 (18%), Positives = 99/252 (39%), Gaps = 16/252 (6%) Query: 14 ILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLNSN 73 ++A + V+ W A +G ++ ++V AL ++ + + + + I D+ + Sbjct: 243 LVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQ-LSSGSRDRMILQRDIRTP 301 Query: 74 NPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINC 133 G + + + + D + + +GG D +W+ S + Q+ + A + Sbjct: 302 PLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLS-PVQQYTEHLAAVKA 360 Query: 134 VCLHPNQAELIV---GDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVN- 189 + P+Q L+ G I W+ T Q I + + + A+ + + + Sbjct: 361 IAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCI-DTGSQVCNLAWSKHANELVSTHG 419 Query: 190 -STGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWR 248 S VW +TQ+ K+ H+ L SPD + T + D+T + W Sbjct: 420 YSQNQILVWKYPS-----LTQV---AKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWN 471 Query: 249 TSNFSLMTELSI 260 + + T+ S+ Sbjct: 472 VFSKTRSTKESV 483 >4FHN-A nrPDB Length = 394 Score = 32.3 bits (72), Expect = 0.30, Method: Compositional matrix adjust. Identities = 39/146 (26%), Positives = 59/146 (40%), Gaps = 33/146 (22%) Query: 104 GEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHP-NQAELIVGDQSGAIHIWD----LK 158 G+DCT IW L + +++P V P N +LIVG+++G I I+D L Sbjct: 164 GDDCTLIIWRLTDEG-PILAGYPLSSPGISVQFRPSNPNQLIVGERNGNIRIFDWTLNLS 222 Query: 159 TDHNEQ--LIPEPEV-------SITSAH-------------IDPDASYMAAVNSTGNCYV 196 + N Q L+ P + + + H I D S + A+ +G Sbjct: 223 AEENSQTELVKNPWLLTLNTLPLVNTCHSSGIASSLANVRWIGSDGSGILAMCKSGAWLR 282 Query: 197 WNLTGG-----IGDEVTQLIPKTKIP 217 WNL I D +L PK +P Sbjct: 283 WNLFANNDYNEISDSTMKLGPKNLLP 308 >4BH6-A nrPDB Length = 308 Score = 32.3 bits (72), Expect = 0.30, Method: Compositional matrix adjust. Identities = 22/103 (21%), Positives = 41/103 (39%), Gaps = 2/103 (1%) Query: 14 ILATAG--YDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLN 71 +LAT G D ++ W ++ I + N + ++ + GY + + Sbjct: 202 VLATGGGTADRRLKIWNVNTSIKMSDIDSGSQICNMVWSKNTNELVTSHGYSKYNLTLWD 261 Query: 72 SNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDL 114 N+ +PI G + + + DG + +G D T R W L Sbjct: 262 CNSMDPIAILKGHSFRVLHLTLSNDGTTVVSGAGDETLRYWKL 304 >5A31-R nrPDB Length = 386 Score = 32.0 bits (71), Expect = 0.33, Method: Compositional matrix adjust. Identities = 22/103 (21%), Positives = 41/103 (39%), Gaps = 2/103 (1%) Query: 14 ILATAG--YDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLN 71 +LAT G D ++ W ++ I + N + ++ + GY + + Sbjct: 271 VLATGGGTADRRLKIWNVNTSIKMSDIDSGSQICNMVWSKNTNELVTSHGYSKYNLTLWD 330 Query: 72 SNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDL 114 N+ +PI G + + + DG + +G D T R W L Sbjct: 331 CNSMDPIAILKGHSFRVLHLTLSNDGTTVVSGAGDETLRYWKL 373 >5WLC-LW nrPDB Length = 554 Score = 32.0 bits (71), Expect = 0.40, Method: Compositional matrix adjust. Identities = 12/42 (28%), Positives = 21/42 (50%) Query: 75 PNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRS 116 P P++ + S+ G +M T G D + +IWD+R+ Sbjct: 264 PEPLVKLLSARGPVNSIAIDRSGYYMATTGADRSMKIWDIRN 305 >3JRP-A nrPDB Length = 379 Score = 31.6 bits (70), Expect = 0.46, Method: Compositional matrix adjust. Identities = 31/121 (25%), Positives = 48/121 (39%), Gaps = 18/121 (14%) Query: 14 ILATAGYDHTVRFWQAHSGICTRTVQH--QDSQVNALEVTPDRS---MIAAAGYQHIRMY 68 ILA+ YD V W+ +G ++ H + VN+++ P ++ A+ + + Sbjct: 71 ILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVV 130 Query: 69 DLNSNNPNPIISYD----GVNK-NIASVGFHEDG--------RWMYTGGEDCTARIWDLR 115 + N I D GVN + A EDG R TGG D +IW Sbjct: 131 EFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYN 190 Query: 116 S 116 S Sbjct: 191 S 191 >6ELZ-p nrPDB Length = 460 Score = 31.6 bits (70), Expect = 0.48, Method: Compositional matrix adjust. Identities = 23/97 (23%), Positives = 42/97 (43%), Gaps = 5/97 (5%) Query: 228 FSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGE----SSRGWMWGCAFSGDSQ 283 F + LL T D K +S SL E + P S+ W+ S+ Sbjct: 57 FLIEGELLRTSLHDYLTKKGLSSEASLNVEYTRAILPPSYLNSFSNEDWVSSLDVGDGSK 116 Query: 284 YIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAF 320 +I++ S D + R W + +G ++++Y GH + + + Sbjct: 117 HIISGSYDGIVRTWDL-SGNVQKQYSGHSGPIRAVKY 152 Score = 28.5 bits (62), Expect = 4.2, Method: Compositional matrix adjust. Identities = 24/107 (22%), Positives = 47/107 (43%), Gaps = 7/107 (6%) Query: 17 TAGY----DHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLNS 72 T GY DHT++ W + C T S ++ +++ + + +HI ++D Sbjct: 301 TVGYSVSQDHTIKTWDLVTARCIDTRTTSYSLLSIAQLSTLNLLACGSSARHITLHDPRV 360 Query: 73 NNPNPIISYDGV-NKNIASV--GFHEDGRWMYTGGEDCTARIWDLRS 116 + + + +KN S E+ + +G D T ++WD+RS Sbjct: 361 GASSKVTQQQLIGHKNFVSSLDTCPENEYILCSGSHDGTVKVWDVRS 407 >4BZK-B nrPDB Length = 297 Score = 31.2 bits (69), Expect = 0.57, Method: Compositional matrix adjust. Identities = 31/121 (25%), Positives = 48/121 (39%), Gaps = 18/121 (14%) Query: 14 ILATAGYDHTVRFWQAHSGICTRTVQH--QDSQVNALEVTPDRS---MIAAAGYQHIRMY 68 ILA+ YD V W+ +G ++ H + VN+++ P ++ A+ + + Sbjct: 69 ILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVV 128 Query: 69 DLNSNNPNPIISYD----GVNK-NIASVGFHEDG--------RWMYTGGEDCTARIWDLR 115 + N I D GVN + A EDG R TGG D +IW Sbjct: 129 EFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYN 188 Query: 116 S 116 S Sbjct: 189 S 189 >4L9O-A nrPDB Length = 349 Score = 31.2 bits (69), Expect = 0.57, Method: Compositional matrix adjust. Identities = 31/126 (24%), Positives = 54/126 (42%), Gaps = 12/126 (9%) Query: 13 VILATAGYDHTVRFWQAHSGICTRTVQHQDSQ--VNALEVTPDRS---MIAAAGYQHIRM 67 VILA+ YD V W+ +G+ + +H Q VN++ P ++ A+ I + Sbjct: 128 VILASCSYDGKVLIWKEDNGVWNKVAEHSVHQASVNSVSWAPHEYGPVLLCASSDGKISI 187 Query: 68 YDLNSNNP-NPIISYD---GVN-KNIASVGFHEDGRWMYTGGEDCTARIW--DLRSRNLQ 120 + PI+ GVN + A + ++ R +GG D +IW D ++ Sbjct: 188 VEFKDGGALEPIVIQGHAIGVNAASWAPISLPDNTRRFVSGGCDNLVKIWRYDDAAKTFI 247 Query: 121 CQRIFQ 126 + FQ Sbjct: 248 EEEAFQ 253 >4XYI-A nrPDB Length = 430 Score = 31.2 bits (69), Expect = 0.60, Method: Compositional matrix adjust. Identities = 71/322 (22%), Positives = 115/322 (35%), Gaps = 99/322 (30%) Query: 40 HQDSQVNALEVTPDRSMIAAA------GYQHIRMYDLNSNNPNPIIS--YDGVNKNIASV 91 H + VN P I A GY ++DLN PI+ + ++ S Sbjct: 129 HHEGDVNKARFMPQNPDIIATLGLNGNGY----IFDLNLYREQPIVQTGHQACLRHHTSE 184 Query: 92 GFH------EDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIV 145 GF ++G + TG ED + +WD++ ++L ++ V AP++ H +V Sbjct: 185 GFGLGWNFIQEGT-LATGTEDTSICVWDIKGKSLSLEKSIDV-APVSVYHRHT----AVV 238 Query: 146 GDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGD 205 D H+ +A L + D Sbjct: 239 ND--------------------------LQFHLQHEA----------------LLTSVSD 256 Query: 206 EVTQLIPKTKIP----------AHTRYALQCRFSP-DSTLLATCSADQTCKIWRTSNFSL 254 + T I T++P AH + F+P + LLAT SAD T +W L Sbjct: 257 DCTLQIHDTRLPSSSSASQCVKAHEQPVNGVAFNPFNDYLLATASADHTVALWDLRR--L 314 Query: 255 MTELSIKSGNPGESSRGWMWGCAFS-GDSQYIVTASSDNLARLWCV------------ET 301 L G+ E ++ +S D +VT+S+D +W + E Sbjct: 315 NQRLHTLEGHEDE-----VYNVQWSPHDEPILVTSSTDRRVCVWDLSKIGEEQTVEDSED 369 Query: 302 G--EIKREYGGHQKAVVCLAFN 321 G E+ +GGH V L++N Sbjct: 370 GAPELMFMHGGHTNRVSDLSWN 391 >3JRO-A nrPDB Length = 753 Score = 30.8 bits (68), Expect = 0.76, Method: Compositional matrix adjust. Identities = 31/121 (25%), Positives = 48/121 (39%), Gaps = 18/121 (14%) Query: 14 ILATAGYDHTVRFWQAHSGICTRTVQH--QDSQVNALEVTPDRS---MIAAAGYQHIRMY 68 ILA+ YD V W+ +G ++ H + VN+++ P ++ A+ + + Sbjct: 69 ILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVV 128 Query: 69 DLNSNNPNPIISYD----GVNK-NIASVGFHEDG--------RWMYTGGEDCTARIWDLR 115 + N I D GVN + A EDG R TGG D +IW Sbjct: 129 EFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYN 188 Query: 116 S 116 S Sbjct: 189 S 189 >5XYH-A nrPDB Length = 425 Score = 30.8 bits (68), Expect = 0.84, Method: Compositional matrix adjust. Identities = 16/60 (26%), Positives = 23/60 (38%) Query: 193 NCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNF 252 + YVW GG D ++ IP + RY +PD TL W ++F Sbjct: 355 HAYVWGKGGGESDGSSKYIPNKQGKGFDRYCDPTYTTPDGTLTGALPNAPIAGTWFHAHF 414 >3EI3-B nrPDB Length = 383 Score = 30.4 bits (67), Expect = 1.0, Method: Compositional matrix adjust. Identities = 16/59 (27%), Positives = 29/59 (49%), Gaps = 3/59 (5%) Query: 100 MYTGGEDCTARIWDLRSRNLQCQRIFQV--NAPINCVCLHP-NQAELIVGDQSGAIHIW 155 M T D T ++WDLR+ + I ++ P+N +P + +L+ DQ I ++ Sbjct: 220 MATSSVDATVKLWDLRNIKDKNSYIAEMPHEKPVNAAYFNPTDSTKLLTTDQRNEIRVY 278 >1PI6-A nrPDB Length = 615 Score = 30.4 bits (67), Expect = 1.2, Method: Compositional matrix adjust. Identities = 32/112 (28%), Positives = 46/112 (41%), Gaps = 8/112 (7%) Query: 10 SDPVILATAGYDHTVRFWQA---HSGICTRTVQHQDSQVNALEVTPDRS--MIAAAGYQH 64 S P+ T G D +V F+Q RT Q S V +E +PD +I + Sbjct: 171 SRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRK 230 Query: 65 IRMYDLNSNNPNPIISYDG--VNKNIASVGFHEDGRWMYTGGEDCTARIWDL 114 I +D S I D V I ++ + D + T G D T R+WD+ Sbjct: 231 ISCFDGKSGEFLKYIEDDQEPVQGGIFALSWL-DSQKFATVGADATIRVWDV 281 >5WYJ-BE nrPDB Length = 939 Score = 30.0 bits (66), Expect = 1.3, Method: Compositional matrix adjust. Identities = 12/32 (37%), Positives = 17/32 (53%) Query: 83 GVNKNIASVGFHEDGRWMYTGGEDCTARIWDL 114 G + I + F +GRW+ + D T R WDL Sbjct: 583 GHSNRITAFDFSPEGRWIVSASLDSTIRTWDL 614 >3ACP-A nrPDB Length = 417 Score = 30.0 bits (66), Expect = 1.3, Method: Compositional matrix adjust. Identities = 25/88 (28%), Positives = 34/88 (38%), Gaps = 14/88 (15%) Query: 218 AHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSG-NPGE--SSRGWMW 274 AH + +F P L + S D KIW S+K G NP R + Sbjct: 134 AHVSEITKLKFFPSGEALISSSQDMQLKIW-----------SVKDGSNPRTLIGHRATVT 182 Query: 275 GCAFSGDSQYIVTASSDNLARLWCVETG 302 A + +++AS D RLW TG Sbjct: 183 DIAIIDRGRNVLSASLDGTIRLWECGTG 210 >3BG0-A nrPDB Length = 316 Score = 29.6 bits (65), Expect = 2.1, Method: Compositional matrix adjust. Identities = 18/51 (35%), Positives = 27/51 (52%), Gaps = 3/51 (5%) Query: 14 ILATAGYDHTVRFWQAHSGICTRTVQH--QDSQVNALEVTP-DRSMIAAAG 61 ILA+ YD V W+ +G ++ +H DS VN++ P D +I A G Sbjct: 73 ILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACG 123 Score = 29.6 bits (65), Expect = 2.1, Method: Compositional matrix adjust. Identities = 27/94 (28%), Positives = 40/94 (42%), Gaps = 8/94 (8%) Query: 233 TLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDN 292 T LATCS+D++ KI+ N + ++ G W A + + S D Sbjct: 26 TRLATCSSDRSVKIFDVRNGGQILIADLR----GHEGPVWQVAWAHPMYGNILASCSYDR 81 Query: 293 LARLWCVETG--EIKREYGGHQKAV--VCLAFND 322 +W E G E E+ GH +V VC A +D Sbjct: 82 KVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHD 115 >3CFV-B nrPDB Length = 414 Score = 29.3 bits (64), Expect = 2.4, Method: Compositional matrix adjust. Identities = 21/68 (30%), Positives = 30/68 (44%), Gaps = 11/68 (16%) Query: 198 NLTGGIGDEVTQLI----------PKTKIPAHTRYALQCRFSPDST-LLATCSADQTCKI 246 +L G + D+ +I P + AHT F+P S +LAT SAD+T + Sbjct: 243 SLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVAL 302 Query: 247 WRTSNFSL 254 W N L Sbjct: 303 WDLRNLKL 310 Score = 28.9 bits (63), Expect = 2.9, Method: Compositional matrix adjust. Identities = 38/162 (23%), Positives = 62/162 (38%), Gaps = 12/162 (7%) Query: 15 LATAGYDHTVRFWQAHSG------ICTRTVQHQDSQVN---ALEVTPDRSMIAAAGYQHI 65 L +A DHTV W ++G + + + S V A + + + A Q + Sbjct: 195 LLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESLFGSVADDQKL 254 Query: 66 RMYDLNSNN-PNPIISYDGVNKNIASVGFHEDGRWMY-TGGEDCTARIWDLRSRNLQCQR 123 ++D SN P D + + F+ ++ TG D T +WDLR+ L+ Sbjct: 255 MIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHT 314 Query: 124 IFQVNAPINCVCLHP-NQAELIVGDQSGAIHIWDLKTDHNEQ 164 I V P N+ L +++WDL EQ Sbjct: 315 FESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQ 356 >6C0F-s nrPDB Length = 807 Score = 29.3 bits (64), Expect = 2.5, Method: Compositional matrix adjust. Identities = 10/34 (29%), Positives = 18/34 (52%) Query: 81 YDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDL 114 Y G + ++ G W+ TG +D T R+W++ Sbjct: 433 YAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEI 466 Score = 28.5 bits (62), Expect = 3.7, Method: Compositional matrix adjust. Identities = 19/56 (33%), Positives = 28/56 (50%), Gaps = 8/56 (14%) Query: 64 HIRMYDLNSNNPN--PIISYDGVNKNIASVG-----FHEDGRWMYTGGEDCTARIW 112 H +YD NP P+ G +K I S+G +H W+++ G D TAR+W Sbjct: 751 HATVYDDMMKNPMIVPLKKLTG-HKVINSLGVLDAIWHPREAWLFSAGADNTARLW 805 >6CB1-s nrPDB Length = 569 Score = 29.3 bits (64), Expect = 2.5, Method: Compositional matrix adjust. Identities = 10/34 (29%), Positives = 18/34 (52%) Query: 81 YDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDL 114 Y G + ++ G W+ TG +D T R+W++ Sbjct: 195 YAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEI 228 Score = 28.9 bits (63), Expect = 3.3, Method: Compositional matrix adjust. Identities = 22/90 (24%), Positives = 41/90 (45%), Gaps = 14/90 (15%) Query: 36 RTVQHQDSQVNALEVTPDRSMIAAAGYQ------HIRMYDLNSNNPN--PIISYDGVNKN 87 +T+++ + V ++ + ++A H +YD NP P+ G +K Sbjct: 479 KTLRYHEKAVRSVNFHKKLPLFSSAADDGTIHVFHATVYDDMMKNPMIVPLKKLTG-HKV 537 Query: 88 IASVG-----FHEDGRWMYTGGEDCTARIW 112 I S+G +H W+++ G D TAR+W Sbjct: 538 INSLGVLDAIWHPREAWLFSAGADNTARLW 567 >6EM1-m nrPDB Length = 807 Score = 29.3 bits (64), Expect = 2.7, Method: Compositional matrix adjust. Identities = 10/34 (29%), Positives = 18/34 (52%) Query: 81 YDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDL 114 Y G + ++ G W+ TG +D T R+W++ Sbjct: 433 YAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEI 466 Score = 28.5 bits (62), Expect = 4.3, Method: Compositional matrix adjust. Identities = 19/56 (33%), Positives = 28/56 (50%), Gaps = 8/56 (14%) Query: 64 HIRMYDLNSNNPN--PIISYDGVNKNIASVG-----FHEDGRWMYTGGEDCTARIW 112 H +YD NP P+ G +K I S+G +H W+++ G D TAR+W Sbjct: 751 HATVYDDMMKNPMIVPLKKLTG-HKVINSLGVLDAIWHPREAWLFSAGADNTARLW 805 >5WLC-SG nrPDB Length = 573 Score = 28.9 bits (63), Expect = 3.0, Method: Compositional matrix adjust. Identities = 21/95 (22%), Positives = 39/95 (41%), Gaps = 7/95 (7%) Query: 218 AHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCA 277 H L SPD + T D+ +W T + S + + P + RG + A Sbjct: 234 GHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVI------PTKDRRGEVLSLA 287 Query: 278 FSGDSQYIVTASSDNLARLWCV-ETGEIKREYGGH 311 F +S + + +D R + + + +++ YG H Sbjct: 288 FRKNSDQLYASCADFKIRTYSINQFSQLEILYGHH 322 >5WJC-A nrPDB Length = 430 Score = 28.9 bits (63), Expect = 3.1, Method: Compositional matrix adjust. Identities = 45/187 (24%), Positives = 73/187 (39%), Gaps = 38/187 (20%) Query: 134 VCLHPN-QAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAH---IDPDASYMAAVN 189 +C +PN L G + I +WD++T S TS+ I P A Y + Sbjct: 188 LCWNPNLPGNLATGAEDQVICLWDVQTQ-----------SFTSSETKVISPIAKYHRHTD 236 Query: 190 STGNCYVW----NLTGGIGDEVTQLIPKTK----------IPAHTRYALQCRFSP-DSTL 234 + L + D+ T I T+ I AH++ +P + L Sbjct: 237 IVNDVQFHPQHEALLASVSDDCTLQIHDTRLNPEEEAPKVIQAHSKAINAVAINPFNDYL 296 Query: 235 LATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSG-DSQYIVTASSDNL 293 LAT SAD+T +W N L G+ E ++G +S D + ++S+D Sbjct: 297 LATASADKTVALWDLRN--PYQRLHTLEGHEDE-----VYGLEWSPHDEPILASSSTDRR 349 Query: 294 ARLWCVE 300 +W +E Sbjct: 350 VCIWDLE 356 >3WJ9-A nrPDB Length = 412 Score = 28.9 bits (63), Expect = 3.6, Method: Compositional matrix adjust. Identities = 33/149 (22%), Positives = 53/149 (35%), Gaps = 21/149 (14%) Query: 119 LQCQRIFQVNAPINCVCLHPNQAE--LIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSA 176 C+ PI+ VC + + E ++ G I+D + + + P P ++ Sbjct: 259 FDCRVDLDREGPIHDVCWNADSKEFGIVYGYMPAKTAIFDNRANVVSIIPPAPRNTLI-- 316 Query: 177 HIDPDASYMAAVNSTGNCYVWNLTGGIG--DEVTQLIPKTKIPAHTRYALQCRFSPDSTL 234 P++ Y+ NL G I D + T + A C FSPDS Sbjct: 317 -FSPNSRYILLAG------FGNLQGSIDIFDAANNMKKITTVEAAN--CTYCEFSPDSQF 367 Query: 235 LATC------SADQTCKIWRTSNFSLMTE 257 L T D + KIW + + E Sbjct: 368 LLTAVTSPRLRVDNSIKIWHITGAPMFYE 396 >4J0X-A nrPDB Length = 451 Score = 28.5 bits (62), Expect = 3.9, Method: Compositional matrix adjust. Identities = 21/95 (22%), Positives = 39/95 (41%), Gaps = 7/95 (7%) Query: 218 AHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCA 277 H L SPD + T D+ +W T + S + + P + RG + A Sbjct: 112 GHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVI------PTKDRRGEVLSLA 165 Query: 278 FSGDSQYIVTASSDNLARLWCV-ETGEIKREYGGH 311 F +S + + +D R + + + +++ YG H Sbjct: 166 FRKNSDQLYASCADFKIRTYSINQFSQLEILYGHH 200 >6E29-D nrPDB Length = 345 Score = 28.1 bits (61), Expect = 5.2, Method: Compositional matrix adjust. Identities = 16/56 (28%), Positives = 29/56 (51%), Gaps = 2/56 (3%) Query: 83 GVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHP 138 G +KNI S+ + GR++ + + +WDL ++ + R + AP+ LHP Sbjct: 65 GHSKNITSLSWSRCGRYLLSACQGWKVILWDL--QDGKRYREVRFRAPVYGAELHP 118 >6N8P-A nrPDB Length = 979 Score = 27.7 bits (60), Expect = 6.3, Method: Composition-based stats. Identities = 13/23 (56%), Positives = 15/23 (65%), Gaps = 1/23 (4%) Query: 14 ILATAGYDHTVRFWQAHSGICTR 36 +L T D TVRFW A SG+C R Sbjct: 426 LLLTGHEDGTVRFWDA-SGVCLR 447 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 5WBU-D nrPDB 399 e-112 5FVM-C nrPDB 290 7e-79 6EMK-B nrPDB 282 2e-76 5NNZ-B nrPDB 265 2e-71 5M25-A nrPDB 241 3e-64 5MZH-A nrPDB 240 8e-64 3DM0-A nrPDB 234 5e-62 2H9P-A nrPDB 230 5e-61 4V6W-Ag nrPDB 230 6e-61 6QX9-5O nrPDB 228 3e-60 6QX9-4B nrPDB 226 8e-60 6G51-g nrPDB 225 2e-59 5OPT-p nrPDB 223 6e-59 4V8M-A7 nrPDB 222 2e-58 6HHQ-h nrPDB 220 7e-58 6F3T-A nrPDB 211 5e-55 6MZM-G nrPDB 207 6e-54 1VYH-C nrPDB 206 9e-54 5FL8-q nrPDB 201 2e-52 6HQA-B nrPDB 201 4e-52 6ID0-T nrPDB 200 5e-52 3JAP-g nrPDB 198 2e-51 5WYK-BB nrPDB 198 4e-51 3MKQ-A nrPDB 184 3e-47 5Y88-O nrPDB 183 9e-47 2YNP-A nrPDB 180 8e-46 4BTS-AR nrPDB 175 3e-44 3JB9-L nrPDB 173 8e-44 5NZU-C nrPDB 170 6e-43 5GAN-H nrPDB 168 3e-42 5WYJ-BC nrPDB 166 1e-41 6J6H-n nrPDB 165 2e-41 5UZ7-B nrPDB 165 3e-41 3JB9-g nrPDB 162 2e-40 4V7E-Bg nrPDB 161 3e-40 6Q8F-A nrPDB 160 6e-40 5Z56-q nrPDB 160 1e-39 5OQL-J nrPDB 159 2e-39 5K1B-B nrPDB 158 5e-39 5XYI-g nrPDB 157 8e-39 6GMH-W nrPDB 156 1e-38 6N9G-C nrPDB 153 8e-38 4LG8-A nrPDB 152 1e-37 5WLC-LO nrPDB 152 2e-37 5I2T-A nrPDB 149 2e-36 1NR0-A nrPDB 147 6e-36 3ODT-A nrPDB 144 5e-35 6EOJ-D nrPDB 136 1e-32 6BX3-A nrPDB 134 4e-32 4A11-B nrPDB 129 2e-30 4AEZ-A nrPDB 128 4e-30 6CHG-D nrPDB 127 6e-30 5MWJ-A nrPDB 121 6e-28 5A9Q-2 nrPDB 119 1e-27 5OQL-L nrPDB 114 7e-26 5K19-A nrPDB 112 3e-25 5N4A-A nrPDB 110 8e-25 4U1E-I nrPDB 106 1e-23 5A9Q-0 nrPDB 106 2e-23 5BJS-A nrPDB 104 5e-23 5CXC-A nrPDB 88 4e-18 4E5Z-B nrPDB 86 3e-17 Sequences not found previously or not previously below threshold: 6QDV-o nrPDB 169 2e-42 5YZG-W nrPDB 169 2e-42 3FM0-A nrPDB 158 3e-39 5OQL-d nrPDB 144 6e-35 5WLC-LU nrPDB 131 5e-31 5G04-R nrPDB 128 3e-30 4YCZ-A nrPDB 127 8e-30 4GGA-A nrPDB 126 1e-29 5WJC-A nrPDB 126 2e-29 5LCW-Q nrPDB 124 5e-29 2HES-X nrPDB 122 2e-28 3JRO-A nrPDB 122 2e-28 6CHG-A nrPDB 121 3e-28 5L9T-R nrPDB 120 7e-28 3C9C-A nrPDB 120 8e-28 4N14-A nrPDB 119 1e-27 4J0W-A nrPDB 119 1e-27 4L9O-A nrPDB 119 2e-27 6ELZ-p nrPDB 119 2e-27 3CFV-B nrPDB 118 3e-27 5Y1U-A nrPDB 118 3e-27 3JRP-A nrPDB 114 5e-26 5K0Y-T nrPDB 114 6e-26 4XYI-A nrPDB 114 7e-26 4BZK-B nrPDB 111 4e-25 4XFV-A nrPDB 110 1e-24 4OWR-A nrPDB 103 1e-22 6BX3-B nrPDB 102 2e-22 5WYJ-BE nrPDB 100 6e-22 3BG0-A nrPDB 99 2e-21 5A31-R nrPDB 99 3e-21 4BH6-A nrPDB 96 2e-20 5WLC-LJ nrPDB 94 6e-20 5CXB-B nrPDB 94 7e-20 2AQ5-A nrPDB 91 7e-19 5OQL-X nrPDB 91 7e-19 6EM1-m nrPDB 90 1e-18 5YZG-2 nrPDB 90 1e-18 6C0F-s nrPDB 90 2e-18 6CB1-s nrPDB 89 2e-18 5OV3-A nrPDB 89 3e-18 3JZG-A nrPDB 88 4e-18 5FA5-B nrPDB 88 6e-18 1PI6-A nrPDB 86 1e-17 4G56-B nrPDB 86 1e-17 3ACP-A nrPDB 86 2e-17 3F3P-A nrPDB 84 6e-17 3W15-A nrPDB 84 1e-16 5WLC-SG nrPDB 84 1e-16 2PM9-A nrPDB 83 1e-16 4J0X-A nrPDB 83 2e-16 5WLC-LN nrPDB 83 3e-16 2P9P-C nrPDB 82 4e-16 6F1U-h nrPDB 81 6e-16 3I2N-A nrPDB 79 2e-15 4PSX-B nrPDB 79 2e-15 5M89-A nrPDB 79 3e-15 5A9Q-7 nrPDB 78 5e-15 6E29-D nrPDB 77 7e-15 3DWL-C nrPDB 73 1e-13 3JB9-S nrPDB 71 6e-13 5WLC-LW nrPDB 69 4e-12 5MC6-j nrPDB 67 1e-11 6IYY-A nrPDB 65 5e-11 5TF2-A nrPDB 64 7e-11 5LTD-A nrPDB 64 8e-11 3DW8-B nrPDB 63 1e-10 5AMS-A nrPDB 61 6e-10 6N8P-A nrPDB 58 7e-09 5WLC-LV nrPDB 57 9e-09 5AJA-A nrPDB 56 3e-08 2I3T-A nrPDB 55 3e-08 3EI3-B nrPDB 54 7e-08 5WLC-LS nrPDB 54 1e-07 4AV8-A nrPDB 49 2e-06 4FHN-A nrPDB 49 3e-06 5WLC-LH nrPDB 47 1e-05 3WJ9-A nrPDB 46 2e-05 6CVZ-A nrPDB 46 3e-05 2VDU-B nrPDB 45 5e-05 4R40-A nrPDB 44 6e-05 5K1H-B nrPDB 43 2e-04 4NOX-A nrPDB 42 4e-04 5WLC-LL nrPDB 41 7e-04 4IMM-A nrPDB 40 0.002 5OLJ-A nrPDB 39 0.004 5GRS-A nrPDB 37 0.010 4YHC-A nrPDB 37 0.012 5BPW-A nrPDB 37 0.015 5BPT-A nrPDB 34 0.064 5CWW-B nrPDB 33 0.16 1C5K-A nrPDB 33 0.20 2EEP-A nrPDB 32 0.30 3US8-A nrPDB 31 0.58 3MWP-A nrPDB 31 0.66 6IGB-A nrPDB 31 0.81 2H47-A nrPDB 30 1.3 5WLC-LK nrPDB 30 1.4 2EIG-A nrPDB 30 1.8 5TXC-A nrPDB 29 2.2 1AOM-A nrPDB 29 2.6 5SUM-A nrPDB 29 2.9 2QC5-A nrPDB 29 3.0 6BN7-A nrPDB 28 4.5 5JN2-A nrPDB 28 5.0 3MA6-A nrPDB 28 5.0 2QT9-A nrPDB 28 6.2 1HJS-A nrPDB 28 6.2 1NQH-A nrPDB 28 6.8 3R3L-A nrPDB 28 7.3 2FTW-A nrPDB 27 7.7 >5WBU-D nrPDB Length = 328 Score = 399 bits (1026), Expect = e-112, Method: Composition-based stats. Identities = 326/326 (100%), Positives = 326/326 (100%) Query: 1 MNTSPGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAA 60 MNTSPGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAA Sbjct: 3 MNTSPGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAA 62 Query: 61 GYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQ 120 GYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQ Sbjct: 63 GYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQ 122 Query: 121 CQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDP 180 CQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDP Sbjct: 123 CQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDP 182 Query: 181 DASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSA 240 DASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSA Sbjct: 183 DASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSA 242 Query: 241 DQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVE 300 DQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVE Sbjct: 243 DQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVE 302 Query: 301 TGEIKREYGGHQKAVVCLAFNDSVLG 326 TGEIKREYGGHQKAVVCLAFNDSVLG Sbjct: 303 TGEIKREYGGHQKAVVCLAFNDSVLG 328 >5FVM-C nrPDB Length = 303 Score = 290 bits (741), Expect = 7e-79, Method: Composition-based stats. Identities = 144/312 (46%), Positives = 198/312 (63%), Gaps = 12/312 (3%) Query: 12 PVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLN 71 VILA+AGYDHT+RFW+A +G+C+RT+QH DSQVN LE+T D+ +AAAG+ H+R+YD+ Sbjct: 2 SVILASAGYDHTIRFWEALTGVCSRTIQHADSQVNRLEITSDKKYLAAAGHLHVRLYDIR 61 Query: 72 SNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPI 131 SNNPNP+ S++G N+ S+ F ++ RWM + ED T ++WD+RS ++Q R ++ NAP+ Sbjct: 62 SNNPNPVSSFEGHKGNVTSIAFQQENRWMVSSSEDGTIKVWDVRSPSVQ--RNYKHNAPV 119 Query: 132 NCVCLHPNQAELIVGDQSGAIHIWDLKTDHNE-QLIPEPEVSITSAHIDPDASYMAAVNS 190 N V +HPNQ ELI DQ G I IWDL + QL PE + S + D S + A N+ Sbjct: 120 NEVAIHPNQGELISCDQDGNIRIWDLGENQCTNQLTPEDNTPLQSLSVASDGSMLVAGNN 179 Query: 191 TGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTS 250 GNCYVW + + + L P TK +HT+Y + S D LATCSAD T ++W Sbjct: 180 KGNCYVWRMPHHT--DASTLEPVTKFKSHTKYITRVLLSADVKNLATCSADHTARVWNIE 237 Query: 251 NFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGG 310 + + + + W+W CAFS DS Y+VTA SD+ RLW + T EI R+YGG Sbjct: 238 DNYQLET-------TLDGHQRWVWDCAFSADSAYLVTACSDHYVRLWDLSTSEIVRQYGG 290 Query: 311 HQKAVVCLAFND 322 H K VC+A ND Sbjct: 291 HHKGAVCVALND 302 Score = 73.6 bits (179), Expect = 1e-13, Method: Composition-based stats. Identities = 24/138 (17%), Positives = 49/138 (35%), Gaps = 9/138 (6%) Query: 7 TVGSDPVILATAGYDHTVRFW------QAHSGICTRTVQHQDSQVNALEVTPDRSMIAAA 60 +V SD +L W A + + + + ++ D +A Sbjct: 166 SVASDGSMLVAGNNKGNCYVWRMPHHTDASTLEPVTKFKSHTKYITRVLLSADVKNLATC 225 Query: 61 GYQHI-RMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNL 119 H R++++ N + DG + + F D ++ T D R+WDL + + Sbjct: 226 SADHTARVWNIEDNYQLET-TLDGHQRWVWDCAFSADSAYLVTACSDHYVRLWDLSTSEI 284 Query: 120 QCQRIFQVNAPINCVCLH 137 ++ + CV L+ Sbjct: 285 -VRQYGGHHKGAVCVALN 301 >6EMK-B nrPDB Length = 303 Score = 282 bits (721), Expect = 2e-76, Method: Composition-based stats. Identities = 144/312 (46%), Positives = 199/312 (63%), Gaps = 12/312 (3%) Query: 12 PVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLN 71 VIL +AGYDHT+RFW+A +G+C+RT+QH DSQVN LE+T D+ ++A AG+Q++R+YD+ Sbjct: 2 SVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIR 61 Query: 72 SNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPI 131 + NPNP+ S++G N+ SV F +D RWM T ED T ++WD+RS ++ R ++ NAP+ Sbjct: 62 TTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIP--RNYKHNAPV 119 Query: 132 NCVCLHPNQAELIVGDQSGAIHIWDLKTDHN-EQLIPEPEVSITSAHIDPDASYMAAVNS 190 N V +HPNQ ELI D+ G I IWDL + QL PE + S+ S + D S +AA N+ Sbjct: 120 NEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANT 179 Query: 191 TGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTS 250 GNCYVW + + + L P TK AH+ Y + S D LATCSAD T ++W Sbjct: 180 KGNCYVWEMPNHT--DASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSID 237 Query: 251 NFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGG 310 + + + + W+W CAFS DS Y+VTASSD+ RLW + T EI R+YGG Sbjct: 238 DDFKLET-------TLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGG 290 Query: 311 HQKAVVCLAFND 322 H K VC+A ND Sbjct: 291 HHKGAVCVALND 302 Score = 105 bits (261), Expect = 4e-23, Method: Composition-based stats. Identities = 33/226 (14%), Positives = 77/226 (34%), Gaps = 17/226 (7%) Query: 11 DPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPD-RSMIAAAGYQHIRMYD 69 D + T+ D T++ W S R + ++ VN + + P+ +I+ +IR++D Sbjct: 86 DNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAPVNEVVIHPNQGELISCDRDGNIRIWD 144 Query: 70 LNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRN-----LQCQRI 124 L N ++ + + S+ DG + +W++ + + Sbjct: 145 LGENQCTHQLTPEDDTS-LQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKF 203 Query: 125 FQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTD-HNEQLIPEPEVSITSAHIDPDAS 183 + I + L + L +W + D E + + + D++ Sbjct: 204 RAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSA 263 Query: 184 YMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFS 229 Y+ +S +W+L+ H + A+ + Sbjct: 264 YLVTASSDHYVRLWDLSTREIVRQYG--------GHHKGAVCVALN 301 Score = 74.0 bits (180), Expect = 7e-14, Method: Composition-based stats. Identities = 24/138 (17%), Positives = 53/138 (38%), Gaps = 9/138 (6%) Query: 7 TVGSDPVILATAGYDHTVRFWQAHSG------ICTRTVQHQDSQVNALEVTPDRSMIAAA 60 ++ SD +LA A W+ + + + + + ++ D +A Sbjct: 166 SMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATC 225 Query: 61 GYQHI-RMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNL 119 H R++ ++ + + DG + + F D ++ T D R+WDL +R + Sbjct: 226 SADHTARVWSIDDDFKLET-TLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREI 284 Query: 120 QCQRIFQVNAPINCVCLH 137 ++ + CV L+ Sbjct: 285 -VRQYGGHHKGAVCVALN 301 >5NNZ-B nrPDB Length = 415 Score = 265 bits (678), Expect = 2e-71, Method: Composition-based stats. Identities = 68/316 (21%), Positives = 125/316 (39%), Gaps = 21/316 (6%) Query: 8 VGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEV-TPDRSMIAAAGYQ-HI 65 + T YD T + W SG T++ + V A+ P IA + Sbjct: 100 LNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTC 159 Query: 66 RMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIF 125 +++ + + ++ G I + F+ + TG D TA++WD+++ + + Sbjct: 160 KLWSVETGKCYH--TFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGE-EVYTLR 216 Query: 126 QVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYM 185 +A I + + + +I G + +WD T ++ I+SA + D S + Sbjct: 217 GHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLI 276 Query: 186 AAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCK 245 + C +W+ T G + H L F L+AT SAD T + Sbjct: 277 LTGSMDKTCKLWDATNGK--------CVATLTGHDDEILDSCFDYTGKLIATASADGTAR 328 Query: 246 IWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIK 305 I+ + + +L E G + +F+ +++T SSD AR+W +TG+ Sbjct: 329 IFSAATRKCIAKL--------EGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCL 380 Query: 306 REYGGHQKAVVCLAFN 321 + GH + AFN Sbjct: 381 QVLEGHTDEIFSCAFN 396 Score = 195 bits (496), Expect = 2e-50, Method: Composition-based stats. Identities = 56/322 (17%), Positives = 112/322 (34%), Gaps = 34/322 (10%) Query: 15 LATAGYDHTVRFW-----------QAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAG-Y 62 L TA V+ H+ + ++ + + + S Sbjct: 54 LLTASRTEQVKLLIQRLQEKLGQNSNHTFYLFKVLKAHILPLTNVALNKSGSCFITGSYD 113 Query: 63 QHIRMYDLNSNNPNPIISYDGVNKNIASVGFH-EDGRWMYTGGEDCTARIWDLRSRNLQC 121 + +++D S + +G + ++ F+ G + TG D T ++W + + +C Sbjct: 114 RTCKLWDTASGEELN--TLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETG--KC 169 Query: 122 QRIF-QVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDP 180 F A I C+ +P + G +WD++ + I S + Sbjct: 170 YHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNT 229 Query: 181 DASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSA 240 + + VW+ G + + H F+ D +L+ T S Sbjct: 230 SGDRIITGSFDHTVVVWDADTGRKVNI--------LIGHCAEISSASFNWDCSLILTGSM 281 Query: 241 DQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVE 300 D+TCK+W +N + L+ + F + I TAS+D AR++ Sbjct: 282 DKTCKLWDATNGKCVATLT--------GHDDEILDSCFDYTGKLIATASADGTARIFSAA 333 Query: 301 TGEIKREYGGHQKAVVCLAFND 322 T + + GH+ + ++FN Sbjct: 334 TRKCIAKLEGHEGEISKISFNP 355 Score = 181 bits (458), Expect = 5e-46, Method: Composition-based stats. Identities = 47/243 (19%), Positives = 88/243 (36%), Gaps = 12/243 (4%) Query: 7 TVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQH-I 65 + ++AT D T + W +G T++ +++ +L I + H + Sbjct: 184 SFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTV 243 Query: 66 RMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIF 125 ++D ++ I G I+S F+ D + TG D T ++WD + Sbjct: 244 VVWDADTGRKVNI--LIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLT- 300 Query: 126 QVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYM 185 + I C + G I+ T + E I+ +P +++ Sbjct: 301 GHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHL 360 Query: 186 AAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCK 245 +S +W+ G +V + HT C F+ ++ T S D TC+ Sbjct: 361 LTGSSDKTARIWDAQTGQCLQV--------LEGHTDEIFSCAFNYKGNIVITGSKDNTCR 412 Query: 246 IWR 248 IWR Sbjct: 413 IWR 415 Score = 166 bits (420), Expect = 1e-41, Method: Composition-based stats. Identities = 45/296 (15%), Positives = 98/296 (33%), Gaps = 29/296 (9%) Query: 40 HQDSQVNALE--VTPDRSMIAAAGYQHIRMY--------DLNSNNPNPIIS-YDGVNKNI 88 + V+AL + ++ A+ + +++ NSN+ + + Sbjct: 36 GPSTDVSALVEEIQKAEPLLTASRTEQVKLLIQRLQEKLGQNSNHTFYLFKVLKAHILPL 95 Query: 89 ASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLH-PNQAELIVGD 147 +V ++ G TG D T ++WD S + + + + + P ++ G Sbjct: 96 TNVALNKSGSCFITGSYDRTCKLWDTASGE-ELNTLEGHRNVVYAIAFNNPYGDKIATGS 154 Query: 148 QSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEV 207 +W ++T I +P ++ +A + +W++ G Sbjct: 155 FDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNG----- 209 Query: 208 TQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGE 267 + H+ + F+ + T S D T +W + L Sbjct: 210 ---EEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNIL--------I 258 Query: 268 SSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDS 323 + +F+ D I+T S D +LW G+ GH ++ F+ + Sbjct: 259 GHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYT 314 Score = 129 bits (325), Expect = 1e-30, Method: Composition-based stats. Identities = 36/154 (23%), Positives = 60/154 (38%), Gaps = 6/154 (3%) Query: 4 SPGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQ 63 S + D ++ T D T + W A +G C T+ D ++ +IA A Sbjct: 265 SSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASAD 324 Query: 64 -HIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQ 122 R++ + I +G I+ + F+ G + TG D TARIWD ++ QC Sbjct: 325 GTARIFSAATRKC--IAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTG--QCL 380 Query: 123 RIF-QVNAPINCVCLHPNQAELIVGDQSGAIHIW 155 ++ I + +I G + IW Sbjct: 381 QVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414 Score = 85.6 bits (210), Expect = 3e-17, Method: Composition-based stats. Identities = 32/111 (28%), Positives = 48/111 (43%), Gaps = 9/111 (8%) Query: 216 IPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWG 275 + AH + + T S D+TCK+W T++ + L E R ++ Sbjct: 88 LKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTL--------EGHRNVVYA 139 Query: 276 CAFS-GDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDSVL 325 AF+ I T S D +LW VETG+ + GH +VCL+FN Sbjct: 140 IAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQST 190 >5M25-A nrPDB Length = 434 Score = 241 bits (615), Expect = 3e-64, Method: Composition-based stats. Identities = 59/297 (19%), Positives = 126/297 (42%), Gaps = 18/297 (6%) Query: 30 HSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQH-IRMYDLNSNNPNPIISYDGVNKNI 88 + T+ V++++ +P+ +A++ I+++ IS G I Sbjct: 133 PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTIS--GHKLGI 190 Query: 89 ASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAP-INCVCLHPNQAELIVGD 147 + V + D + + +D T +IWD+ S +C + + ++ + C +P ++ G Sbjct: 191 SDVAWSSDSNLLVSASDDKTLKIWDVSSG--KCLKTLKGHSNYVFCCNFNPQSNLIVSGS 248 Query: 148 QSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEV 207 ++ IWD+KT + +P +++ H + D S + + + G C +W+ G Sbjct: 249 FDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASG----- 303 Query: 208 TQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGE 267 KT I +FSP+ + + D T K+W S + + + Sbjct: 304 --QCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGH-----K 356 Query: 268 SSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDSV 324 + + ++ ++IV+ S DNL +W ++T EI ++ GH V+ A + + Sbjct: 357 NEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTE 413 Score = 202 bits (514), Expect = 2e-52, Method: Composition-based stats. Identities = 47/295 (15%), Positives = 116/295 (39%), Gaps = 24/295 (8%) Query: 9 GSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQ-HIRM 67 + LA++ D ++ W A+ G +T+ ++ + + D +++ +A +++ Sbjct: 154 SPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKI 213 Query: 68 YDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIF-Q 126 +D++S + + G + + F+ + +G D + RIWD+++ +C + Sbjct: 214 WDVSSGKC--LKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTG--KCLKTLPA 269 Query: 127 VNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQ-LIPEPEVSITSAHIDPDASYM 185 + P++ V + + + ++ G IWD + + LI + ++ P+ Y+ Sbjct: 270 HSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYI 329 Query: 186 AAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFS-PDSTLLATCSADQTC 244 A +W+ + G + + + +Y + FS + + S D Sbjct: 330 LAATLDNTLKLWDYSKG------KCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLV 383 Query: 245 KIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTAS--SDNLARLW 297 IW ++ +L + + A I +A+ +D +LW Sbjct: 384 YIWNLQTKEIVQKL--------QGHTDVVISTACHPTENIIASAALENDKTIKLW 430 Score = 189 bits (480), Expect = 1e-48, Method: Composition-based stats. Identities = 47/249 (18%), Positives = 98/249 (39%), Gaps = 16/249 (6%) Query: 9 GSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQH-IRM 67 SD +L +A D T++ W SG C +T++ + V P ++I + + +R+ Sbjct: 196 SSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRI 255 Query: 68 YDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQV 127 +D+ + + + + +++V F+ DG + + D RIWD S I Sbjct: 256 WDVKTGKC--LKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDD 313 Query: 128 NAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPD---ASY 184 N P++ V PN ++ + +WD + + + + Sbjct: 314 NPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKW 373 Query: 185 MAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSA--DQ 242 + + + Y+WNL + K+ HT + P ++A+ + D+ Sbjct: 374 IVSGSEDNLVYIWNLQTKEIVQ--------KLQGHTDVVISTACHPTENIIASAALENDK 425 Query: 243 TCKIWRTSN 251 T K+W++ Sbjct: 426 TIKLWKSDC 434 Score = 189 bits (479), Expect = 2e-48, Method: Composition-based stats. Identities = 51/248 (20%), Positives = 101/248 (40%), Gaps = 16/248 (6%) Query: 79 ISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHP 138 + G K ++SV F +G W+ + D +IW + + I I+ V Sbjct: 139 FTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE-KTISGHKLGISDVAWSS 197 Query: 139 NQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWN 198 + L+ + IWD+ + + + + + +P ++ + + + + +W+ Sbjct: 198 DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 257 Query: 199 LTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTEL 258 + G +PAH+ F+ D +L+ + S D C+IW T++ + L Sbjct: 258 VKTGK--------CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL 309 Query: 259 SIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCL 318 + + FS + +YI+ A+ DN +LW G+ + Y GH+ C+ Sbjct: 310 -------IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCI 362 Query: 319 AFNDSVLG 326 N SV G Sbjct: 363 FANFSVTG 370 >5MZH-A nrPDB Length = 452 Score = 240 bits (611), Expect = 8e-64, Method: Composition-based stats. Identities = 62/309 (20%), Positives = 115/309 (37%), Gaps = 21/309 (6%) Query: 15 LATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEV-TPDRSMIAAAGYQ-HIRMYDLNS 72 T YD T + W +G T++ + V A+ P I + +++D + Sbjct: 109 FITGSYDRTCKVWNTFTGEEVFTLEGHKNVVYAIAFNNPYGDKIVTGSFDKTCKLWDAYT 168 Query: 73 NNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPIN 132 + G I + F+ + TG D TA++WD+ + + + A I Sbjct: 169 GQLY--YTLKGHQTEIVCLSFNPQSTIIATGSMDNTAKLWDVETGQERA-TLAGHRAEIV 225 Query: 133 CVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTG 192 + + ++ G +WD++T ++ ++S + + + + + Sbjct: 226 SLGFNTGGDLIVTGSFDHDSRLWDVRTGQCVHVLSGHRGEVSSTQFNYAGTLVVSGSIDC 285 Query: 193 NCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNF 252 +W++ G V Q HT L F T + + SAD + +++ T Sbjct: 286 TSRLWDVRSGRCLSVKQ--------GHTDEVLDVAFDAAGTKMVSASADGSARLYHTLTG 337 Query: 253 SLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQ 312 L G + AF+ ++TASSD RLW +TGE + GH Sbjct: 338 VCQHTL--------VGHEGEISKVAFNPQGTRLITASSDKTCRLWDCDTGECLQVLEGHT 389 Query: 313 KAVVCLAFN 321 + AFN Sbjct: 390 DEIFSCAFN 398 Score = 238 bits (606), Expect = 3e-63, Method: Composition-based stats. Identities = 58/302 (19%), Positives = 122/302 (40%), Gaps = 22/302 (7%) Query: 4 SPGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQ 63 + + T +D T + W A++G T++ +++ L P ++IA Sbjct: 141 AIAFNNPYGDKIVTGSFDKTCKLWDAYTGQLYYTLKGHQTEIVCLSFNPQSTIIATGSMD 200 Query: 64 HI-RMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQ 122 + +++D+ + + G I S+GF+ G + TG D +R+WD+R+ QC Sbjct: 201 NTAKLWDVETGQERA--TLAGHRAEIVSLGFNTGGDLIVTGSFDHDSRLWDVRTG--QCV 256 Query: 123 RIF-QVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPD 181 + ++ + ++ G +WD+++ + + D Sbjct: 257 HVLSGHRGEVSSTQFNYAGTLVVSGSIDCTSRLWDVRSGRCLSVKQGHTDEVLDVAFDAA 316 Query: 182 ASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSAD 241 + M + ++ G+ +++ G + + + H + F+P T L T S+D Sbjct: 317 GTKMVSASADGSARLYHTLTG--------VCQHTLVGHEGEISKVAFNPQGTRLITASSD 368 Query: 242 QTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVET 301 +TC++W + L E ++ CAF+ + +I+T S DN R+W T Sbjct: 369 KTCRLWDCDTGECLQVL--------EGHTDEIFSCAFNYEGDFIITGSKDNTCRIWKALT 420 Query: 302 GE 303 Sbjct: 421 AS 422 Score = 193 bits (490), Expect = 1e-49, Method: Composition-based stats. Identities = 49/295 (16%), Positives = 104/295 (35%), Gaps = 21/295 (7%) Query: 30 HSGICTRTVQHQDSQVNALEVTPDRSMIAAAG-YQHIRMYDLNSNNPNPIISYDGVNKNI 88 HS + ++ + + +++ N+ + + +G + Sbjct: 82 HSFTLFKVLRAHILPLTNCAFNKSGDRFITGSYDRTCKVW--NTFTGEEVFTLEGHKNVV 139 Query: 89 ASVGFH-EDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGD 147 ++ F+ G + TG D T ++WD + L + I C+ +P + G Sbjct: 140 YAIAFNNPYGDKIVTGSFDKTCKLWDAYTGQLY-YTLKGHQTEIVCLSFNPQSTIIATGS 198 Query: 148 QSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEV 207 +WD++T + I S + + + + +W++ G V Sbjct: 199 MDNTAKLWDVETGQERATLAGHRAEIVSLGFNTGGDLIVTGSFDHDSRLWDVRTGQCVHV 258 Query: 208 TQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGE 267 + H +F+ TL+ + S D T ++W + + + + Sbjct: 259 --------LSGHRGEVSSTQFNYAGTLVVSGSIDCTSRLWDVRSGRCL--------SVKQ 302 Query: 268 SSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFND 322 + AF +V+AS+D ARL+ TG + GH+ + +AFN Sbjct: 303 GHTDEVLDVAFDAAGTKMVSASADGSARLYHTLTGVCQHTLVGHEGEISKVAFNP 357 >3DM0-A nrPDB Length = 694 Score = 234 bits (596), Expect = 5e-62, Method: Composition-based stats. Identities = 55/323 (17%), Positives = 115/323 (35%), Gaps = 39/323 (12%) Query: 1 MNTSPGTVGSDPVILATAGYDHTVRFW-----QAHSGICTRTVQHQDSQVNALEVTPDRS 55 M T+ T + I+ +A D ++ W G+ R + V + ++ D Sbjct: 384 MVTAIATPIDNADIIVSASRDKSIILWKLTKDDKAYGVAQRRLTGHSHFVEDVVLSSDGQ 443 Query: 56 MIAAAGYQ-HIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDL 114 + + +R++DL + + G K++ SV F D R + + D T ++W+ Sbjct: 444 FALSGSWDGELRLWDLAAG--VSTRRFVGHTKDVLSVAFSLDNRQIVSASRDRTIKLWNT 501 Query: 115 RSRNLQCQRIF-----QVNAPINCVCLHPN--QAELIVGDQSGAIHIWDLKTDHNEQLIP 167 +C+ ++CV PN Q ++ + +W+L + Sbjct: 502 LG---ECKYTISEGGEGHRDWVSCVRFSPNTLQPTIVSASWDKTVKVWNLSNCKLRSTLA 558 Query: 168 EPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCR 227 +++ + PD S A+ G +W+L G + Sbjct: 559 GHTGYVSTVAVSPDGSLCASGGKDGVVLLWDLAEGKKLYSLEA---------NSVIHALC 609 Query: 228 FSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRG-----------WMWGC 276 FSP+ L + + KIW + S++ +L + E + + Sbjct: 610 FSPNRYWLCAAT-EHGIKIWDLESKSIVEDLKVDLKAEAEKADNSGPAATKRKVIYCTSL 668 Query: 277 AFSGDSQYIVTASSDNLARLWCV 299 +S D + + +D + R+W + Sbjct: 669 NWSADGSTLFSGYTDGVIRVWGI 691 Score = 163 bits (411), Expect = 1e-40, Method: Composition-based stats. Identities = 46/288 (15%), Positives = 100/288 (34%), Gaps = 31/288 (10%) Query: 33 ICTRTVQHQDSQVNALEVTPDR-SMIAAAGYQH-IRMYDLNSNNP---NPIISYDGVNKN 87 + T++ V A+ D +I +A I ++ L ++ G + Sbjct: 373 VLKGTMRAHTDMVTAIATPIDNADIIVSASRDKSIILWKLTKDDKAYGVAQRRLTGHSHF 432 Query: 88 IASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGD 147 + V DG++ +G D R+WDL + +R + V + +++ Sbjct: 433 VEDVVLSSDGQFALSGSWDGELRLWDLAAGVS-TRRFVGHTKDVLSVAFSLDNRQIVSAS 491 Query: 148 QSGAIHIWDLKTDHNEQLI----PEPEVSITSAHIDPD--ASYMAAVNSTGNCYVWNLTG 201 + I +W+ + I ++ P+ + + + VWNL Sbjct: 492 RDRTIKLWNTL-GECKYTISEGGEGHRDWVSCVRFSPNTLQPTIVSASWDKTVKVWNL-- 548 Query: 202 GIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIK 261 + ++ + HT Y SPD +L A+ D +W + + L Sbjct: 549 ------SNCKLRSTLAGHTGYVSTVAVSPDGSLCASGGKDGVVLLWDLAEGKKLYSLEAN 602 Query: 262 SGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYG 309 S + FS + ++ A +++ ++W +E+ I + Sbjct: 603 S---------VIHALCFSPNRYWLCAA-TEHGIKIWDLESKSIVEDLK 640 Score = 154 bits (389), Expect = 5e-38, Method: Composition-based stats. Identities = 41/251 (16%), Positives = 88/251 (35%), Gaps = 21/251 (8%) Query: 80 SYDGVNKNIASVGFHEDG-RWMYTGGEDCTARIW----DLRSRNLQCQRIFQVNAPINCV 134 + + ++ D + + D + +W D ++ + +R+ + + V Sbjct: 377 TMRAHTDMVTAIATPIDNADIIVSASRDKSIILWKLTKDDKAYGVAQRRLTGHSHFVEDV 436 Query: 135 CLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNC 194 L + + G G + +WDL + + + S D + + + Sbjct: 437 VLSSDGQFALSGSWDGELRLWDLAAGVSTRRFVGHTKDVLSVAFSLDNRQIVSASRDRTI 496 Query: 195 YVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPD--STLLATCSADQTCKIWRTSNF 252 +WN G +++ H + RFSP+ + + S D+T K+W SN Sbjct: 497 KLWNTLGECKYTISEG-----GEGHRDWVSCVRFSPNTLQPTIVSASWDKTVKVWNLSNC 551 Query: 253 SLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQ 312 L + L+ +G ++ A S D + D + LW + G+ Sbjct: 552 KLRSTLAGHTG--------YVSTVAVSPDGSLCASGGKDGVVLLWDLAEGKKLYSLEA-N 602 Query: 313 KAVVCLAFNDS 323 + L F+ + Sbjct: 603 SVIHALCFSPN 613 Score = 97.1 bits (240), Expect = 8e-21, Method: Composition-based stats. Identities = 32/166 (19%), Positives = 62/166 (37%), Gaps = 17/166 (10%) Query: 165 LIPEPEVSITSAHIDPDA-SYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYA 223 + +T+ D + + + + +W LT D+ + + ++ H+ + Sbjct: 377 TMRAHTDMVTAIATPIDNADIIVSASRDKSIILWKLT---KDDKAYGVAQRRLTGHSHFV 433 Query: 224 LQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQ 283 S D + S D ++W + + + + AFS D++ Sbjct: 434 EDVVLSSDGQFALSGSWDGELRLWDLAAGVSTRRFVGHTKD--------VLSVAFSLDNR 485 Query: 284 YIVTASSDNLARLWCVETGEIKREY----GGHQKAVVCLAFNDSVL 325 IV+AS D +LW GE K GH+ V C+ F+ + L Sbjct: 486 QIVSASRDRTIKLWNT-LGECKYTISEGGEGHRDWVSCVRFSPNTL 530 Score = 75.6 bits (184), Expect = 3e-14, Method: Composition-based stats. Identities = 25/114 (21%), Positives = 48/114 (42%), Gaps = 4/114 (3%) Query: 209 QLIPKTKIPAHTRYALQCRFSPDS-TLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGE 267 L+ K + AHT D+ ++ + S D++ +W+ + + + Sbjct: 371 GLVLKGTMRAHTDMVTAIATPIDNADIIVSASRDKSIILWKLTKDD---KAYGVAQRRLT 427 Query: 268 SSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFN 321 ++ S D Q+ ++ S D RLW + G R + GH K V+ +AF+ Sbjct: 428 GHSHFVEDVVLSSDGQFALSGSWDGELRLWDLAAGVSTRRFVGHTKDVLSVAFS 481 >2H9P-A nrPDB Length = 329 Score = 230 bits (587), Expect = 5e-61, Method: Composition-based stats. Identities = 59/297 (19%), Positives = 126/297 (42%), Gaps = 18/297 (6%) Query: 30 HSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQH-IRMYDLNSNNPNPIISYDGVNKNI 88 + T+ V++++ +P+ +A++ I+++ IS G I Sbjct: 28 PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTIS--GHKLGI 85 Query: 89 ASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAP-INCVCLHPNQAELIVGD 147 + V + D + + +D T +IWD+ S +C + + ++ + C +P ++ G Sbjct: 86 SDVAWSSDSNLLVSASDDKTLKIWDVSSG--KCLKTLKGHSNYVFCCNFNPQSNLIVSGS 143 Query: 148 QSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEV 207 ++ IWD+KT + +P +++ H + D S + + + G C +W+ G Sbjct: 144 FDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASG----- 198 Query: 208 TQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGE 267 KT I +FSP+ + + D T K+W S + + + Sbjct: 199 --QCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGH-----K 251 Query: 268 SSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDSV 324 + + ++ ++IV+ S DNL +W ++T EI ++ GH V+ A + + Sbjct: 252 NEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTE 308 Score = 193 bits (489), Expect = 1e-49, Method: Composition-based stats. Identities = 47/295 (15%), Positives = 116/295 (39%), Gaps = 24/295 (8%) Query: 9 GSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQ-HIRM 67 + LA++ D ++ W A+ G +T+ ++ + + D +++ +A +++ Sbjct: 49 SPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKI 108 Query: 68 YDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIF-Q 126 +D++S + + G + + F+ + +G D + RIWD+++ +C + Sbjct: 109 WDVSSGKC--LKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTG--KCLKTLPA 164 Query: 127 VNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQ-LIPEPEVSITSAHIDPDASYM 185 + P++ V + + + ++ G IWD + + LI + ++ P+ Y+ Sbjct: 165 HSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYI 224 Query: 186 AAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFS-PDSTLLATCSADQTC 244 A +W+ + G + + + +Y + FS + + S D Sbjct: 225 LAATLDNTLKLWDYSKG------KCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLV 278 Query: 245 KIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTAS--SDNLARLW 297 IW ++ +L + + A I +A+ +D +LW Sbjct: 279 YIWNLQTKEIVQKL--------QGHTDVVISTACHPTENIIASAALENDKTIKLW 325 Score = 181 bits (458), Expect = 4e-46, Method: Composition-based stats. Identities = 47/249 (18%), Positives = 98/249 (39%), Gaps = 16/249 (6%) Query: 9 GSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQH-IRM 67 SD +L +A D T++ W SG C +T++ + V P ++I + + +R+ Sbjct: 91 SSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRI 150 Query: 68 YDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQV 127 +D+ + + + + +++V F+ DG + + D RIWD S I Sbjct: 151 WDVKTGKC--LKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDD 208 Query: 128 NAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPD---ASY 184 N P++ V PN ++ + +WD + + + + Sbjct: 209 NPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKW 268 Query: 185 MAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSA--DQ 242 + + + Y+WNL + K+ HT + P ++A+ + D+ Sbjct: 269 IVSGSEDNLVYIWNLQTKEIVQ--------KLQGHTDVVISTACHPTENIIASAALENDK 320 Query: 243 TCKIWRTSN 251 T K+W++ Sbjct: 321 TIKLWKSDC 329 Score = 181 bits (458), Expect = 5e-46, Method: Composition-based stats. Identities = 51/248 (20%), Positives = 101/248 (40%), Gaps = 16/248 (6%) Query: 79 ISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHP 138 + G K ++SV F +G W+ + D +IW + + I I+ V Sbjct: 34 FTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE-KTISGHKLGISDVAWSS 92 Query: 139 NQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWN 198 + L+ + IWD+ + + + + + +P ++ + + + + +W+ Sbjct: 93 DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 152 Query: 199 LTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTEL 258 + G +PAH+ F+ D +L+ + S D C+IW T++ + L Sbjct: 153 VKTGK--------CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL 204 Query: 259 SIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCL 318 + + FS + +YI+ A+ DN +LW G+ + Y GH+ C+ Sbjct: 205 -------IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCI 257 Query: 319 AFNDSVLG 326 N SV G Sbjct: 258 FANFSVTG 265 >4V6W-Ag nrPDB Length = 318 Score = 230 bits (586), Expect = 6e-61, Method: Composition-based stats. Identities = 57/308 (18%), Positives = 113/308 (36%), Gaps = 22/308 (7%) Query: 3 TSPGTVGSDPVILATAGYDHTVRFW------QAHSGICTRTVQHQDSQVNALEVTPDRSM 56 T T DP + +A D T+ W + G + + ++ + ++ D + Sbjct: 19 TQIATNPKDPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRLYGHSHFISDVVLSSDGNY 78 Query: 57 IAAAGYQ-HIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLR 115 + + +R++DL + ++G K++ SV F D R + +G D T ++W+ Sbjct: 79 ALSGSWDQTLRLWDLAAGKT--TRRFEGHTKDVLSVAFSADNRQIVSGSRDKTIKLWNTL 136 Query: 116 SRNLQCQRIFQVNAPINCVCLHPN--QAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSI 173 + + ++CV PN ++ + +W+L + + Sbjct: 137 AECKFTIQEDGHTDWVSCVRFSPNHSNPIIVSCGWDRTVKVWNLANCKLKNNHHGHNGYL 196 Query: 174 TSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDST 233 + + PD S + +W+L G + H FSP+ Sbjct: 197 NTVTVSPDGSLCTSGGKDSKALLWDLNDGKNLYTLE---------HNDIINALCFSPNRY 247 Query: 234 LLATCSADQTCKIWRTSNFSLMTELSIKSGNP-GESSRGWMWGCAFSGDSQYIVTASSDN 292 L + KIW + + EL + +P ++ + A+S D Q + SDN Sbjct: 248 WLCVAYG-PSIKIWDLACKKTVEELRPEVVSPTSKADQPQCLSLAWSTDGQTLFAGYSDN 306 Query: 293 LARLWCVE 300 R+W V Sbjct: 307 TIRVWQVS 314 Score = 151 bits (382), Expect = 3e-37, Method: Composition-based stats. Identities = 44/252 (17%), Positives = 87/252 (34%), Gaps = 24/252 (9%) Query: 80 SYDGVNKNIASVGFHE-DGRWMYTGGEDCTARIWDLR-----SRNLQCQRIFQVNAPINC 133 + G N + + + D + + D T +W L + +R++ + I+ Sbjct: 10 TLIGHNGWVTQIATNPKDPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRLYGHSHFISD 69 Query: 134 VCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGN 193 V L + + G + +WDL + + S D + + + Sbjct: 70 VVLSSDGNYALSGSWDQTLRLWDLAAGKTTRRFEGHTKDVLSVAFSADNRQIVSGSRDKT 129 Query: 194 CYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPD--STLLATCSADQTCKIWRTSN 251 +WN + + HT + RFSP+ + ++ +C D+T K+W +N Sbjct: 130 IKLWNTLAECKFTIQE-------DGHTDWVSCVRFSPNHSNPIIVSCGWDRTVKVWNLAN 182 Query: 252 FSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGH 311 L N G++ S D + D+ A LW + G+ H Sbjct: 183 CKLK--------NNHHGHNGYLNTVTVSPDGSLCTSGGKDSKALLWDLNDGKNLYTLE-H 233 Query: 312 QKAVVCLAFNDS 323 + L F+ + Sbjct: 234 NDIINALCFSPN 245 Score = 150 bits (378), Expect = 8e-37, Method: Composition-based stats. Identities = 45/286 (15%), Positives = 93/286 (32%), Gaps = 28/286 (9%) Query: 33 ICTRTVQHQDSQVNALEVTPDRS--MIAAAGYQHIRMY----DLNSNNPNPIISYDGVNK 86 T+ + V + P +I+A+ + + ++ D ++N P G + Sbjct: 6 QLRGTLIGHNGWVTQIATNPKDPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRLYGHSH 65 Query: 87 NIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVG 146 I+ V DG + +G D T R+WDL + +R + V + +++ G Sbjct: 66 FISDVVLSSDGNYALSGSWDQTLRLWDLAAGKT-TRRFEGHTKDVLSVAFSADNRQIVSG 124 Query: 147 DQSGAIHIWDLKTDHNEQLI-PEPEVSITSAHIDPD--ASYMAAVNSTGNCYVWNLTGGI 203 + I +W+ + + ++ P+ + + VWNL Sbjct: 125 SRDKTIKLWNTLAECKFTIQEDGHTDWVSCVRFSPNHSNPIIVSCGWDRTVKVWNLAN-- 182 Query: 204 GDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSG 263 K H Y SPD +L + D +W ++ + L Sbjct: 183 ------CKLKNNHHGHNGYLNTVTVSPDGSLCTSGGKDSKALLWDLNDGKNLYTLE---- 232 Query: 264 NPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYG 309 + FS + ++ A ++W + + E Sbjct: 233 -----HNDIINALCFSPNRYWLCVAYG-PSIKIWDLACKKTVEELR 272 >6QX9-5O nrPDB Length = 357 Score = 228 bits (580), Expect = 3e-60, Method: Composition-based stats. Identities = 65/291 (22%), Positives = 121/291 (41%), Gaps = 17/291 (5%) Query: 10 SDPVILATAGYDHTVRFWQAHSGICTR--TVQHQDSQVNALEVTPDRSMIAAAGYQ-HIR 66 + LA+AG+D + W + G C T++ V L D SM+ +A + Sbjct: 76 PNGSTLASAGFDRLILLWNVY-GDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVA 134 Query: 67 MYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMY-TGGEDCTARIWDLRSRNLQCQRIF 125 ++D + + G + S G + TG +D T ++WD+R + + F Sbjct: 135 VWDSETG--ERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKK--AAIQTF 190 Query: 126 QVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYM 185 Q + V + ++I G I +WDL+ + + S+T + + SY+ Sbjct: 191 QNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYL 250 Query: 186 AAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCK 245 + VW++ E I + + + L+C +SPD + +A SAD+ Sbjct: 251 LSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVY 310 Query: 246 IWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARL 296 +W T++ ++ +L +G+ E AF D I++ASSD + Sbjct: 311 VWDTTSRRILYKLPGHAGSINE--------VAFHPDEPIIISASSDKRLYM 353 Score = 199 bits (507), Expect = 1e-51, Method: Composition-based stats. Identities = 45/293 (15%), Positives = 109/293 (37%), Gaps = 13/293 (4%) Query: 34 CTRTVQHQDSQVNALEVTPDRSMIAAAGYQH-IRMYDLNSNNPNPIISYDGVNKNIASVG 92 + + +V + P+ S +A+AG+ I ++++ + + + G + + + Sbjct: 58 PIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNV-YGDCDNYATLKGHSGAVMELH 116 Query: 93 FHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELI-VGDQSGA 151 ++ DG +++ D T +WD + + +R+ + +N +L+ G G Sbjct: 117 YNTDGSMLFSASTDKTVAVWDSETGE-RVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGT 175 Query: 152 IHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLI 211 + +WD++ Q + + + + + + + VW+L Q Sbjct: 176 VKLWDIRKKAAIQTFQN-TYQVLAVTFNDTSDQIISGGIDNDIKVWDL--------RQNK 226 Query: 212 PKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRG 271 + H S + + L + + D T ++W F+ + Sbjct: 227 LTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEK 286 Query: 272 WMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDSV 324 + C++S D I S+D +W + I + GH ++ +AF+ Sbjct: 287 NLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDE 339 Score = 158 bits (400), Expect = 2e-39, Method: Composition-based stats. Identities = 46/248 (18%), Positives = 96/248 (38%), Gaps = 22/248 (8%) Query: 9 GSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQ--HIR 66 +D +L +A D TV W + +G + ++ S VN+ + G ++ Sbjct: 118 NTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVK 177 Query: 67 MYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQ 126 ++D+ I ++ + +V F++ + +GG D ++WDLR L + Sbjct: 178 LWDIR--KKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKL-TYTMRG 233 Query: 127 VNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTD----HNEQLIPEP----EVSITSAHI 178 + + L + L+ + +WD++ ++ E ++ Sbjct: 234 HADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSW 293 Query: 179 DPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATC 238 PD S +AA ++ YVW+ T K+P H + F PD ++ + Sbjct: 294 SPDGSKIAAGSADRFVYVWDTTSR--------RILYKLPGHAGSINEVAFHPDEPIIISA 345 Query: 239 SADQTCKI 246 S+D+ + Sbjct: 346 SSDKRLYM 353 Score = 103 bits (257), Expect = 1e-22, Method: Composition-based stats. Identities = 30/151 (19%), Positives = 59/151 (39%), Gaps = 8/151 (5%) Query: 7 TVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAA-AGYQHI 65 T + + G D+ ++ W T T++ V L ++ + S + + A + Sbjct: 200 TFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTV 259 Query: 66 RMYDLN--SNNPNPIISYDG--VN--KNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNL 119 R++D+ + + + G N KN+ + DG + G D +WD SR + Sbjct: 260 RVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRI 319 Query: 120 QCQRIFQVNAPINCVCLHPNQAELIVGDQSG 150 ++ IN V HP++ +I Sbjct: 320 -LYKLPGHAGSINEVAFHPDEPIIISASSDK 349 Score = 86.4 bits (212), Expect = 1e-17, Method: Composition-based stats. Identities = 24/120 (20%), Positives = 42/120 (35%), Gaps = 7/120 (5%) Query: 199 LTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTEL 258 L G + P + H C+F P+ + LA+ D+ +W Sbjct: 45 LQAGPPRCSSLQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDC----- 99 Query: 259 SIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCL 318 + + G + ++ D + +AS+D +W ETGE + GH V Sbjct: 100 --DNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSC 157 >6QX9-4B nrPDB Length = 522 Score = 226 bits (577), Expect = 8e-60, Method: Composition-based stats. Identities = 67/302 (22%), Positives = 117/302 (38%), Gaps = 29/302 (9%) Query: 9 GSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTP---------DRSMIAA 59 + +LATA + + W T++ ++ V A+ P D ++ + Sbjct: 240 SPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASC 299 Query: 60 AGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNL 119 A ++++ L+S+ P + +G +A V +H GR++ T D + R+WDL ++ Sbjct: 300 AADGSVKLWSLDSDEP--VADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQE- 356 Query: 120 QCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHID 179 + + + + H + + G +WDL+T + I + Sbjct: 357 EILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFS 416 Query: 180 PDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSP-DSTLLATC 238 P+ ++A + C VW+L Q IPAH +F P L T Sbjct: 417 PNGYHIATGSGDNTCKVWDL--------RQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTG 468 Query: 239 SADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWC 298 + D T KIW +S + L+ G + G S D Q I T S D +LW Sbjct: 469 AYDNTAKIWTHPGWSPLKTLA--------GHEGKVMGLDISSDGQLIATCSYDRTFKLWM 520 Query: 299 VE 300 E Sbjct: 521 AE 522 Score = 162 bits (409), Expect = 2e-40, Method: Composition-based stats. Identities = 52/292 (17%), Positives = 101/292 (34%), Gaps = 29/292 (9%) Query: 40 HQDSQVNALEVTPDRSMIAAAGYQH-IRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGR 98 D ++ +P+ M+A A + +++ + + N + + G N N+ ++ FH Sbjct: 229 GDDRPISYCHFSPNSKMLATACWSGLCKLWSVP--DCNLLHTLRGHNTNVGAIVFHPKST 286 Query: 99 W--------MYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSG 150 + + D + ++W L S I + V HP+ L Sbjct: 287 VSLDPKDVNLASCAADGSVKLWSLDSDE-PVADIEGHTVRVARVMWHPSGRFLGTTCYDR 345 Query: 151 AIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQL 210 + +WDL+ + + D S VW+L G Sbjct: 346 SWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMF--- 402 Query: 211 IPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSR 270 + H + FSP+ +AT S D TCK+W + + + + Sbjct: 403 -----LEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIP--------AHQ 449 Query: 271 GWMWGCAFSG-DSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFN 321 + G F +++T + DN A++W + GH+ V+ L + Sbjct: 450 NLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDIS 501 Score = 149 bits (375), Expect = 2e-36, Method: Composition-based stats. Identities = 43/251 (17%), Positives = 79/251 (31%), Gaps = 25/251 (9%) Query: 80 SYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPN 139 S G ++ I+ F + + + T ++W + NL + N + + HP Sbjct: 226 SQIGDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNL-LHTLRGHNTNVGAIVFHPK 284 Query: 140 QA--------ELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNST 191 L G++ +W L +D I V + P ++ Sbjct: 285 STVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYD 344 Query: 192 GNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSN 251 + +W+L + H+ F D +L T D ++W Sbjct: 345 RSWRLWDLEAQEEILHQE--------GHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRT 396 Query: 252 FSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGH 311 + L E ++G FS + +I T S DN ++W + H Sbjct: 397 GRCIMFL--------EGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAH 448 Query: 312 QKAVVCLAFND 322 Q V + F Sbjct: 449 QNLVTGVKFEP 459 Score = 132 bits (333), Expect = 1e-31, Method: Composition-based stats. Identities = 42/218 (19%), Positives = 76/218 (34%), Gaps = 25/218 (11%) Query: 114 LRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSI 173 LRS N C +I + PI+ PN L SG +W + + + ++ Sbjct: 218 LRSLNNFCSQI-GDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNV 276 Query: 174 TSAHIDPDASY--------MAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQ 225 + P ++ +A+ + G+ +W+L P I HT + Sbjct: 277 GAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDS--------DEPVADIEGHTVRVAR 328 Query: 226 CRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYI 285 + P L T D++ ++W + + E ++ AF D Sbjct: 329 VMWHPSGRFLGTTCYDRSWRLWDLE--------AQEEILHQEGHSMGVYDIAFHQDGSLA 380 Query: 286 VTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDS 323 T D R+W + TG GH K + + F+ + Sbjct: 381 GTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPN 418 Score = 52.8 bits (125), Expect = 2e-07, Method: Composition-based stats. Identities = 14/58 (24%), Positives = 22/58 (37%) Query: 268 SSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDSVL 325 + C FS +S+ + TA L +LW V + GH V + F+ Sbjct: 229 GDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKST 286 Score = 32.4 bits (72), Expect = 0.29, Method: Composition-based stats. Identities = 8/20 (40%), Positives = 12/20 (60%) Query: 8 VGSDPVILATAGYDHTVRFW 27 + SD ++AT YD T + W Sbjct: 500 ISSDGQLIATCSYDRTFKLW 519 >6G51-g nrPDB Length = 317 Score = 225 bits (574), Expect = 2e-59, Method: Composition-based stats. Identities = 60/309 (19%), Positives = 114/309 (36%), Gaps = 21/309 (6%) Query: 3 TSPGTVGSDPVILATAGYDHTVRFWQAH-----SGICTRTVQHQDSQVNALEVTPDRSMI 57 T T P ++ +A D T+ W+ GI R ++ V+ + ++ D Sbjct: 19 TQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFA 78 Query: 58 AAAGYQ-HIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRS 116 + + +R++DL + + G K++ SV F D R + +G D T ++W+ Sbjct: 79 LSGSWDGTLRLWDLTTGTT--TRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLG 136 Query: 117 RNLQCQRIFQVNAPINCVCLHPNQ--AELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSIT 174 + + ++CV PN ++ + +W+L + + Sbjct: 137 VCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLN 196 Query: 175 SAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTL 234 + + PD S A+ G +W+L G FSP+ Sbjct: 197 TVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTL---------DGGDIINALCFSPNRYW 247 Query: 235 LATCSADQTCKIWRTSNFSLMTELSIKSGNP-GESSRGWMWGCAFSGDSQYIVTASSDNL 293 L + + KIW ++ EL + + ++ A+S D Q + +DNL Sbjct: 248 LCAATG-PSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNL 306 Query: 294 ARLWCVETG 302 R+W V G Sbjct: 307 VRVWQVTIG 315 Score = 141 bits (356), Expect = 3e-34, Method: Composition-based stats. Identities = 43/251 (17%), Positives = 86/251 (34%), Gaps = 23/251 (9%) Query: 80 SYDGVNKNIASVGFHED-GRWMYTGGEDCTARIW----DLRSRNLQCQRIFQVNAPINCV 134 + G N + + + + D T +W D + + + + + ++ V Sbjct: 10 TLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDV 69 Query: 135 CLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNC 194 + + + G G + +WDL T + + S D + + + Sbjct: 70 VISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTI 129 Query: 195 YVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDST--LLATCSADQTCKIWRTSNF 252 +WN G V +H+ + RFSP+S+ ++ +C D+ K+W +N Sbjct: 130 KLWNTLGVCKYTVQD-------ESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANC 182 Query: 253 SLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQ 312 L T G++ S D + D A LW + G+ G Sbjct: 183 KLKTN--------HIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG-G 233 Query: 313 KAVVCLAFNDS 323 + L F+ + Sbjct: 234 DIINALCFSPN 244 >5OPT-p nrPDB Length = 318 Score = 223 bits (569), Expect = 6e-59, Method: Composition-based stats. Identities = 58/297 (19%), Positives = 121/297 (40%), Gaps = 25/297 (8%) Query: 16 ATAGYDHTVRFW---------QAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQH-I 65 + D+T+ W + G R ++ + V+ + ++ + +A + H + Sbjct: 32 VSTSRDNTLIAWGSNMDRNSEECEYGFPERRLEGHSAFVSDVALSNNGDFAVSASWDHSL 91 Query: 66 RMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIF 125 R+++L + + G K++ SV F D R + +GG D R+W+++ L Sbjct: 92 RLWNLQTGVCQH--KFLGHTKDVLSVTFSPDNRQIVSGGRDNALRVWNVKGECLHTLGRG 149 Query: 126 QVNAPINCVCLHPN--QAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDAS 183 ++CV P+ ++ G + +WD+ + + ITS + PD S Sbjct: 150 AHTDWVSCVRFSPSLETPLIVSGGWDNLVKVWDIASGRLLTDLKGHTNYITSVTVSPDGS 209 Query: 184 YMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQT 243 A+ + G +W+LT G A Q FSP+ + + ++ Sbjct: 210 LCASSDKDGVARLWDLTKGEALSEM---------AAGAPINQICFSPNRYWMCAAT-EKG 259 Query: 244 CKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVE 300 +I+ N ++ EL+ ++ + + A+S D + + +DN+ R+W V Sbjct: 260 IRIFDLENKDVIVELAPEAQQKSKKTPE-CMSIAWSADGNTLYSGYTDNVIRVWSVS 315 Score = 152 bits (383), Expect = 2e-37, Method: Composition-based stats. Identities = 46/247 (18%), Positives = 96/247 (38%), Gaps = 10/247 (4%) Query: 8 VGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQH-IR 66 + ++ +A +DH++R W +G+C V ++ +PD I + G + +R Sbjct: 75 LSNNGDFAVSASWDHSLRLWNLQTGVCQHKFLGHTKDVLSVTFSPDNRQIVSGGRDNALR 134 Query: 67 MYDLNSNNPNPIISYDGVNKNIASVGFHE--DGRWMYTGGEDCTARIWDLRSRNLQCQRI 124 ++++ + ++ V F + + +GG D ++WD+ S L + Sbjct: 135 VWNVK-GECLHTLGRGAHTDWVSCVRFSPSLETPLIVSGGWDNLVKVWDIASGRLLTD-L 192 Query: 125 FQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASY 184 I V + P+ + D+ G +WDL + I P+ + Sbjct: 193 KGHTNYITSVTVSPDGSLCASSDKDGVARLWDLTKGEALSEMAAG-APINQICFSPNRYW 251 Query: 185 MAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPA-HTRYALQCRFSPDSTLLATCSADQT 243 M A G +++L D + +L P+ + + T + +S D L + D Sbjct: 252 MCAATEKG-IRIFDLEN--KDVIVELAPEAQQKSKKTPECMSIAWSADGNTLYSGYTDNV 308 Query: 244 CKIWRTS 250 ++W S Sbjct: 309 IRVWSVS 315 Score = 134 bits (336), Expect = 6e-32, Method: Composition-based stats. Identities = 46/256 (17%), Positives = 92/256 (35%), Gaps = 29/256 (11%) Query: 81 YDGVNKNIASVG---FHEDGRWMYTGGEDCTARIW--DLRSRNLQCQ------RIFQVNA 129 G + ++ E + D T W ++ + +C+ R+ +A Sbjct: 9 LKGHRGWVTALACPQITETYIKAVSTSRDNTLIAWGSNMDRNSEECEYGFPERRLEGHSA 68 Query: 130 PINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVN 189 ++ V L N + ++ +W+L+T + + S PD + + Sbjct: 69 FVSDVALSNNGDFAVSASWDHSLRLWNLQTGVCQHKFLGHTKDVLSVTFSPDNRQIVSGG 128 Query: 190 STGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPD--STLLATCSADQTCKIW 247 VWN+ G + + AHT + RFSP + L+ + D K+W Sbjct: 129 RDNALRVWNVKG-------ECLHTLGRGAHTDWVSCVRFSPSLETPLIVSGGWDNLVKVW 181 Query: 248 RTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKRE 307 ++ L+T+L + ++ S D ++ D +ARLW + GE E Sbjct: 182 DIASGRLLTDLKGHTN--------YITSVTVSPDGSLCASSDKDGVARLWDLTKGEALSE 233 Query: 308 YGGHQKAVVCLAFNDS 323 + + F+ + Sbjct: 234 MAA-GAPINQICFSPN 248 Score = 116 bits (291), Expect = 1e-26, Method: Composition-based stats. Identities = 31/214 (14%), Positives = 73/214 (34%), Gaps = 29/214 (13%) Query: 123 RIFQVNAPINCVCLHP---NQAELIVGDQSGAIHIW----DLKTDHNEQLIP-----EPE 170 ++ + + + + + + W D ++ E P Sbjct: 8 QLKGHRGWVTALACPQITETYIKAVSTSRDNTLIAWGSNMDRNSEECEYGFPERRLEGHS 67 Query: 171 VSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSP 230 ++ + + + + + + +WNL G + + K HT+ L FSP Sbjct: 68 AFVSDVALSNNGDFAVSASWDHSLRLWNLQTG--------VCQHKFLGHTKDVLSVTFSP 119 Query: 231 DSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSG--DSQYIVTA 288 D+ + + D ++W + L + W+ FS ++ IV+ Sbjct: 120 DNRQIVSGGRDNALRVWNV-KGECLHTLGRGA------HTDWVSCVRFSPSLETPLIVSG 172 Query: 289 SSDNLARLWCVETGEIKREYGGHQKAVVCLAFND 322 DNL ++W + +G + + GH + + + Sbjct: 173 GWDNLVKVWDIASGRLLTDLKGHTNYITSVTVSP 206 Score = 93.7 bits (231), Expect = 9e-20, Method: Composition-based stats. Identities = 28/165 (16%), Positives = 56/165 (33%), Gaps = 15/165 (9%) Query: 166 IPEPEVSITSAH-IDPDASYM--AAVNSTGNCYVWNLTGGIGDEVTQL-IPKTKIPAHTR 221 + +T+ +Y+ + + W E + P+ ++ H+ Sbjct: 9 LKGHRGWVTALACPQITETYIKAVSTSRDNTLIAWGSNMDRNSEECEYGFPERRLEGHSA 68 Query: 222 YALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGD 281 + S + + S D + ++W + + FS D Sbjct: 69 FVSDVALSNNGDFAVSASWDHSLRLWNLQTGVCQHKF--------LGHTKDVLSVTFSPD 120 Query: 282 SQYIVTASSDNLARLWCVETGEIKREYG--GHQKAVVCLAFNDSV 324 ++ IV+ DN R+W V+ GE G H V C+ F+ S+ Sbjct: 121 NRQIVSGGRDNALRVWNVK-GECLHTLGRGAHTDWVSCVRFSPSL 164 Score = 65.2 bits (157), Expect = 3e-11, Method: Composition-based stats. Identities = 24/115 (20%), Positives = 45/115 (39%), Gaps = 6/115 (5%) Query: 213 KTKIPAHTRYALQCRFSPDST----LLATCSADQTCKIW-RTSNFSLMTELSIKSGNPGE 267 + ++ H + P T + S D T W + + E Sbjct: 6 EGQLKGHRGWVTALA-CPQITETYIKAVSTSRDNTLIAWGSNMDRNSEECEYGFPERRLE 64 Query: 268 SSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFND 322 ++ A S + + V+AS D+ RLW ++TG + ++ GH K V+ + F+ Sbjct: 65 GHSAFVSDVALSNNGDFAVSASWDHSLRLWNLQTGVCQHKFLGHTKDVLSVTFSP 119 >4V8M-A7 nrPDB Length = 318 Score = 222 bits (565), Expect = 2e-58, Method: Composition-based stats. Identities = 60/298 (20%), Positives = 122/298 (40%), Gaps = 25/298 (8%) Query: 15 LATAGYDHTVRFW----QAHSGICT-----RTVQHQDSQVNALEVTPDRSMIAAAGYQH- 64 + + D T+ W HS C+ R ++ + V+ + ++ + + +A + H Sbjct: 31 VVSTSRDKTLLSWGPNPDRHSSECSYGLPDRRLEGHSAFVSDVALSNNGNFAVSASWDHS 90 Query: 65 IRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRI 124 +R+++L + + G K++ SV F D R + +GG D R+W+++ + Sbjct: 91 LRLWNLQNGQCQ--YKFLGHTKDVLSVAFSPDNRQIVSGGRDNALRVWNVKGECMHTLSR 148 Query: 125 FQVNAPINCVCLHP--NQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDA 182 ++CV P + ++ G + +WDL T + +TS + PD Sbjct: 149 GAHTDWVSCVRFSPSLDAPVIVSGGWDNLVKVWDLATGRLVTDLKGHTNYVTSVTVSPDG 208 Query: 183 SYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQ 242 S A+ + G +W+LT G A Q FSP+ + + ++ Sbjct: 209 SLCASSDKDGVARLWDLTKGEALSEM---------AAGAPINQICFSPNRYWMCAAT-EK 258 Query: 243 TCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVE 300 +I+ N ++ EL+ + + A+S D + + +DN+ R+W V Sbjct: 259 GIRIFDLENKDIIVELAPE-HQGSKKIVPECVSIAWSADGSTLYSGYTDNVIRVWGVS 315 Score = 147 bits (371), Expect = 6e-36, Method: Composition-based stats. Identities = 42/243 (17%), Positives = 87/243 (35%), Gaps = 8/243 (3%) Query: 8 VGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQH-IR 66 + ++ +A +DH++R W +G C V ++ +PD I + G + +R Sbjct: 75 LSNNGNFAVSASWDHSLRLWNLQNGQCQYKFLGHTKDVLSVAFSPDNRQIVSGGRDNALR 134 Query: 67 MYDLNSNNPNPIISYDGVNKNIASVGFHE--DGRWMYTGGEDCTARIWDLRSRNLQCQRI 124 ++++ +S ++ V F D + +GG D ++WDL + L + Sbjct: 135 VWNVK-GECMHTLSRGAHTDWVSCVRFSPSLDAPVIVSGGWDNLVKVWDLATGRLVTD-L 192 Query: 125 FQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASY 184 + V + P+ + D+ G +WDL + I P+ + Sbjct: 193 KGHTNYVTSVTVSPDGSLCASSDKDGVARLWDLTKGEALSEMAAG-APINQICFSPNRYW 251 Query: 185 MAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTC 244 M A G +++L + +S D + L + D Sbjct: 252 MCAATEKG-IRIFDLENKDIIVELAPEHQGSKKIVPECVS-IAWSADGSTLYSGYTDNVI 309 Query: 245 KIW 247 ++W Sbjct: 310 RVW 312 Score = 136 bits (341), Expect = 2e-32, Method: Composition-based stats. Identities = 46/256 (17%), Positives = 91/256 (35%), Gaps = 29/256 (11%) Query: 81 YDGVNKNIASVG---FHEDGRWMYTGGEDCTARIW--DLRSRNLQCQ------RIFQVNA 129 G + S+ E + + D T W + + +C R+ +A Sbjct: 9 LTGHRGWVTSLACPQTPETATKVVSTSRDKTLLSWGPNPDRHSSECSYGLPDRRLEGHSA 68 Query: 130 PINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVN 189 ++ V L N + ++ +W+L+ + + S PD + + Sbjct: 69 FVSDVALSNNGNFAVSASWDHSLRLWNLQNGQCQYKFLGHTKDVLSVAFSPDNRQIVSGG 128 Query: 190 STGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSP--DSTLLATCSADQTCKIW 247 VWN+ G +++ AHT + RFSP D+ ++ + D K+W Sbjct: 129 RDNALRVWNVKGECMHTLSRG-------AHTDWVSCVRFSPSLDAPVIVSGGWDNLVKVW 181 Query: 248 RTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKRE 307 + L+T+L + ++ S D ++ D +ARLW + GE E Sbjct: 182 DLATGRLVTDLKGHTN--------YVTSVTVSPDGSLCASSDKDGVARLWDLTKGEALSE 233 Query: 308 YGGHQKAVVCLAFNDS 323 + + F+ + Sbjct: 234 MAA-GAPINQICFSPN 248 Score = 122 bits (307), Expect = 2e-28, Method: Composition-based stats. Identities = 34/214 (15%), Positives = 74/214 (34%), Gaps = 29/214 (13%) Query: 123 RIFQVNAPINCVCLHPNQ---AELIVGDQSGAIHIWDLKTDH---------NEQLIPEPE 170 ++ + + +++ + + W D ++ + Sbjct: 8 QLTGHRGWVTSLACPQTPETATKVVSTSRDKTLLSWGPNPDRHSSECSYGLPDRRLEGHS 67 Query: 171 VSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSP 230 ++ + + ++ + + + +WNL G + K HT+ L FSP Sbjct: 68 AFVSDVALSNNGNFAVSASWDHSLRLWNLQNG--------QCQYKFLGHTKDVLSVAFSP 119 Query: 231 DSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSG--DSQYIVTA 288 D+ + + D ++W M LS + W+ FS D+ IV+ Sbjct: 120 DNRQIVSGGRDNALRVWNV-KGECMHTLSRGA------HTDWVSCVRFSPSLDAPVIVSG 172 Query: 289 SSDNLARLWCVETGEIKREYGGHQKAVVCLAFND 322 DNL ++W + TG + + GH V + + Sbjct: 173 GWDNLVKVWDLATGRLVTDLKGHTNYVTSVTVSP 206 Score = 96.0 bits (237), Expect = 2e-20, Method: Composition-based stats. Identities = 31/166 (18%), Positives = 58/166 (34%), Gaps = 17/166 (10%) Query: 166 IPEPEVSITSAHIDP----DASYMAAVNSTGNCYVWN-LTGGIGDEVTQLIPKTKIPAHT 220 + +TS P A+ + + + W E + +P ++ H+ Sbjct: 9 LTGHRGWVTSLA-CPQTPETATKVVSTSRDKTLLSWGPNPDRHSSECSYGLPDRRLEGHS 67 Query: 221 RYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSG 280 + S + + S D + ++W N + + AFS Sbjct: 68 AFVSDVALSNNGNFAVSASWDHSLRLWNLQNGQCQYKF--------LGHTKDVLSVAFSP 119 Query: 281 DSQYIVTASSDNLARLWCVETGEIKREYG--GHQKAVVCLAFNDSV 324 D++ IV+ DN R+W V+ GE H V C+ F+ S+ Sbjct: 120 DNRQIVSGGRDNALRVWNVK-GECMHTLSRGAHTDWVSCVRFSPSL 164 Score = 70.2 bits (170), Expect = 1e-12, Method: Composition-based stats. Identities = 26/115 (22%), Positives = 51/115 (44%), Gaps = 6/115 (5%) Query: 213 KTKIPAHTRYALQCRFSPD----STLLATCSADQTCKIWRTSNFSLMTELS-IKSGNPGE 267 + ++ H + P +T + + S D+T W + +E S E Sbjct: 6 EGQLTGHRGWVTSLA-CPQTPETATKVVSTSRDKTLLSWGPNPDRHSSECSYGLPDRRLE 64 Query: 268 SSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFND 322 ++ A S + + V+AS D+ RLW ++ G+ + ++ GH K V+ +AF+ Sbjct: 65 GHSAFVSDVALSNNGNFAVSASWDHSLRLWNLQNGQCQYKFLGHTKDVLSVAFSP 119 >6HHQ-h nrPDB Length = 319 Score = 220 bits (560), Expect = 7e-58, Method: Composition-based stats. Identities = 60/313 (19%), Positives = 114/313 (36%), Gaps = 26/313 (8%) Query: 3 TSPGTVGSDPVILATAGYDHTVRFW-----QAHSGICTRTVQHQDSQVNALEVTPDRSMI 57 TS T P +L +A D T+ W G+ R+ + V +T D + Sbjct: 21 TSLATSAGQPNLLLSASRDKTLISWKLTGDDQKFGVPVRSFKGHSHIVQDCTLTADGAYA 80 Query: 58 AAAGYQ-HIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRS 116 +A + +R++D+ + + G ++ SV + + +G D T ++W ++ Sbjct: 81 LSASWDKTLRLWDVATGETYQ--RFVGHKSDVMSVDIDKKASMIISGSRDKTIKVWTIKG 138 Query: 117 RNLQCQRIFQVNAPINCVCLHPN------QAELIVGDQSGAIHIWDLKTDHNEQLIPEPE 170 + L + N ++ V + PN +I + W+L E Sbjct: 139 QCLAT--LLGHNDWVSQVRVVPNEKADDDSVTIISAGNDKMVKAWNLNQFQIEADFIGHN 196 Query: 171 VSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSP 230 +I + PD + +A+ G +WNL FSP Sbjct: 197 SNINTLTASPDGTLIASAGKDGEIMLWNLAAKKAMYTLSA---------QDEVFSLAFSP 247 Query: 231 DSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASS 290 + LA +A K++ L+ +L + +++ A+S D Q + + Sbjct: 248 NRYWLAAATATG-IKVFSLDPQYLVDDLRPEFAGYSKAAEPHAVSLAWSADGQTLFAGYT 306 Query: 291 DNLARLWCVETGE 303 DN+ R+W V T Sbjct: 307 DNVIRVWQVMTAN 319 Score = 129 bits (323), Expect = 2e-30, Method: Composition-based stats. Identities = 41/255 (16%), Positives = 78/255 (30%), Gaps = 29/255 (11%) Query: 80 SYDGVNKNIASVGFHEDG-RWMYTGGEDCTARIW----DLRSRNLQCQRIFQVNAPINCV 134 + +G N + S+ + + D T W D + + + + + Sbjct: 12 TLEGHNGWVTSLATSAGQPNLLLSASRDKTLISWKLTGDDQKFGVPVRSFKGHSHIVQDC 71 Query: 135 CLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNC 194 L + A + + +WD+ T Q + + S ID AS + + + Sbjct: 72 TLTADGAYALSASWDKTLRLWDVATGETYQRFVGHKSDVMSVDIDKKASMIISGSRDKTI 131 Query: 195 YVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTL------LATCSADQTCKIWR 248 VW + G + H + Q R P+ + + D+ K W Sbjct: 132 KVWTIKG---------QCLATLLGHNDWVSQVRVVPNEKADDDSVTIISAGNDKMVKAWN 182 Query: 249 TSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREY 308 + F + + + S D I +A D LW + + Sbjct: 183 LNQFQIEADF--------IGHNSNINTLTASPDGTLIASAGKDGEIMLWNLAAKKAMYTL 234 Query: 309 GGHQKAVVCLAFNDS 323 Q V LAF+ + Sbjct: 235 SA-QDEVFSLAFSPN 248 >6F3T-A nrPDB Length = 608 Score = 211 bits (536), Expect = 5e-55, Method: Composition-based stats. Identities = 53/242 (21%), Positives = 99/242 (40%), Gaps = 14/242 (5%) Query: 9 GSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQ-HIRM 67 SD ++ D R + + + V +PDR+ + ++ +R+ Sbjct: 318 ASDLSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRL 377 Query: 68 YDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQV 127 + L + ++ Y G N + F G + +GG D AR+W + + Q RIF Sbjct: 378 WSLQTFTC--LVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLW--ATDHYQPLRIFAG 433 Query: 128 N-APINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMA 186 + A +NC HPN + G + +WD+ + ++ + I S P+ ++A Sbjct: 434 HLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLA 493 Query: 187 AVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKI 246 + G +W++ G + ++ HT RFS D +LA+ S D T ++ Sbjct: 494 TGATDGRVLLWDIGHG--------LMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRL 545 Query: 247 WR 248 W Sbjct: 546 WD 547 Score = 189 bits (480), Expect = 1e-48, Method: Composition-based stats. Identities = 57/290 (19%), Positives = 106/290 (36%), Gaps = 31/290 (10%) Query: 33 ICTRTVQHQDSQVNALEVTPDRSMIAAA-GYQHIRMYDLNSNNPNPIISYDGVNKNIASV 91 IC T + + A++VT D S+IA +R++ + K + SV Sbjct: 269 ICFYTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSVT-------------PKKLRSV 315 Query: 92 GFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGA 151 D + +D RI D ++ + + ++ + P+ P++ L+ + G Sbjct: 316 KQASDLSLIDKESDDVLERIMDEKT-ASELKILYGHSGPVYGASFSPDRNYLLSSSEDGT 374 Query: 152 IHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLI 211 + +W L+T + P Y + +W Sbjct: 375 VRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHY--------Q 426 Query: 212 PKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRG 271 P H RF P+S +AT SAD+T ++W N + + + +G Sbjct: 427 PLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFT--------GHKG 478 Query: 272 WMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFN 321 + FS + +++ T ++D LW + G + E GH V L F+ Sbjct: 479 PIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFS 528 Score = 184 bits (468), Expect = 3e-47, Method: Composition-based stats. Identities = 53/293 (18%), Positives = 97/293 (33%), Gaps = 31/293 (10%) Query: 8 VGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHI-R 66 V D ++A D TVR W +++ D S+I + R Sbjct: 286 VTDDSSLIAGGFADSTVRVWSVTPKKL-----------RSVKQASDLSLIDKESDDVLER 334 Query: 67 MYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQ 126 + D + + I G + + F D ++ + ED T R+W L++ Sbjct: 335 IMDEKTASELKI--LYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYK-G 391 Query: 127 VNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMA 186 N P+ P + G +W ++ + P+++Y+A Sbjct: 392 HNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVA 451 Query: 187 AVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKI 246 ++ +W++ G H FSP+ LAT + D + Sbjct: 452 TGSADRTVRLWDVLNGN--------CVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLL 503 Query: 247 WRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCV 299 W + ++ EL + + FS D + + + S DN RLW Sbjct: 504 WDIGHGLMVGELKGHT--------DTVCSLRFSRDGEILASGSMDNTVRLWDA 548 Score = 171 bits (433), Expect = 4e-43, Method: Composition-based stats. Identities = 45/216 (20%), Positives = 84/216 (38%), Gaps = 8/216 (3%) Query: 6 GTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHI 65 + D L ++ D TVR W + C + + V + +P + G+ + Sbjct: 357 ASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRV 416 Query: 66 -RMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRI 124 R++ +++ P+ + G ++ FH + ++ TG D T R+WD+ + N C RI Sbjct: 417 ARLW--ATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGN--CVRI 472 Query: 125 F-QVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDAS 183 F PI+ + PN L G G + +WD+ + ++ S D Sbjct: 473 FTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGE 532 Query: 184 YMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAH 219 +A+ + +W+ D T T H Sbjct: 533 ILASGSMDNTVRLWDAIKAFEDLETDDF--TTATGH 566 Score = 147 bits (372), Expect = 4e-36, Method: Composition-based stats. Identities = 43/248 (17%), Positives = 86/248 (34%), Gaps = 28/248 (11%) Query: 76 NPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVC 135 ++ + + +V +D + G D T R+W + + L+ V Sbjct: 269 ICFYTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSVTPKKLR------------SVK 316 Query: 136 LHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCY 195 + + + I D KT +++ + A PD +Y+ + + G Sbjct: 317 QASDLSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVR 376 Query: 196 VWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLM 255 +W+L H +FSP + D+ ++W T ++ + Sbjct: 377 LWSLQT--------FTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPL 428 Query: 256 TELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAV 315 + + + F +S Y+ T S+D RLW V G R + GH+ + Sbjct: 429 RIFAGHLAD--------VNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPI 480 Query: 316 VCLAFNDS 323 L F+ + Sbjct: 481 HSLTFSPN 488 >6MZM-G nrPDB Length = 800 Score = 207 bits (526), Expect = 6e-54, Method: Composition-based stats. Identities = 49/213 (23%), Positives = 91/213 (42%), Gaps = 14/213 (6%) Query: 38 VQHQDSQVNALEVTPDRSMIAAAGYQ-HIRMYDLNSNNPNPIISYDGVNKNIASVGFHED 96 + V +PDR+ + ++ +R++ L + ++ Y G N + F Sbjct: 539 LYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTC--LVGYKGHNYPVWDTQFSPY 596 Query: 97 GRWMYTGGEDCTARIWDLRSRNLQCQRIFQVN-APINCVCLHPNQAELIVGDQSGAIHIW 155 G + +GG D AR+W + + Q RIF + A +NC HPN + G + +W Sbjct: 597 GYYFVSGGHDRVARLW--ATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLW 654 Query: 156 DLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTK 215 D+ + ++ + I S P+ ++A + G +W++ G + + Sbjct: 655 DVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHG--------LMVGE 706 Query: 216 IPAHTRYALQCRFSPDSTLLATCSADQTCKIWR 248 + HT RFS D +LA+ S D T ++W Sbjct: 707 LKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739 Score = 174 bits (442), Expect = 3e-44, Method: Composition-based stats. Identities = 45/216 (20%), Positives = 84/216 (38%), Gaps = 8/216 (3%) Query: 6 GTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHI 65 + D L ++ D TVR W + C + + V + +P + G+ + Sbjct: 549 ASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRV 608 Query: 66 -RMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRI 124 R++ +++ P+ + G ++ FH + ++ TG D T R+WD+ + N C RI Sbjct: 609 ARLW--ATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGN--CVRI 664 Query: 125 F-QVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDAS 183 F PI+ + PN L G G + +WD+ + ++ S D Sbjct: 665 FTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGE 724 Query: 184 YMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAH 219 +A+ + +W+ D T T H Sbjct: 725 ILASGSMDNTVRLWDAIKAFEDLETDDF--TTATGH 758 Score = 172 bits (436), Expect = 2e-43, Method: Composition-based stats. Identities = 50/297 (16%), Positives = 91/297 (30%), Gaps = 47/297 (15%) Query: 33 ICTRTVQHQDSQVNALEVTPDRSMIAAA-GYQHIRMYDLNSNNPNPI------------- 78 IC T + + A++VT D S+IA +R+ Sbjct: 461 ICFYTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVXXXXXXXXXXXXXXXXXXXXXXXX 520 Query: 79 ----------------ISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQ 122 G + + F D ++ + ED T R+W L++ Sbjct: 521 XXXXXXXXXXXXXXXXKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVG 580 Query: 123 RIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDA 182 N P+ P + G +W ++ + P++ Sbjct: 581 YK-GHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNS 639 Query: 183 SYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQ 242 +Y+A ++ +W++ G H FSP+ LAT + D Sbjct: 640 NYVATGSADRTVRLWDVLNGN--------CVRIFTGHKGPIHSLTFSPNGRFLATGATDG 691 Query: 243 TCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCV 299 +W + ++ EL + + FS D + + + S DN RLW Sbjct: 692 RVLLWDIGHGLMVGELKGHT--------DTVCSLRFSRDGEILASGSMDNTVRLWDA 740 Score = 169 bits (429), Expect = 1e-42, Method: Composition-based stats. Identities = 44/276 (15%), Positives = 86/276 (31%), Gaps = 46/276 (16%) Query: 76 NPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQC-------------- 121 ++ + + +V +D + G D T R+ Sbjct: 461 ICFYTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVXXXXXXXXXXXXXXXXXXXXXXXX 520 Query: 122 ----------------QRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQL 165 + ++ + P+ P++ L+ + G + +W L+T Sbjct: 521 XXXXXXXXXXXXXXXXKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVG 580 Query: 166 IPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQ 225 + P Y + +W P H Sbjct: 581 YKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHY--------QPLRIFAGHLADVNC 632 Query: 226 CRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYI 285 RF P+S +AT SAD+T ++W N + + + +G + FS + +++ Sbjct: 633 TRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFT--------GHKGPIHSLTFSPNGRFL 684 Query: 286 VTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFN 321 T ++D LW + G + E GH V L F+ Sbjct: 685 ATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFS 720 Score = 130 bits (327), Expect = 7e-31, Method: Composition-based stats. Identities = 30/160 (18%), Positives = 59/160 (36%), Gaps = 16/160 (10%) Query: 164 QLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYA 223 +++ + A PD +Y+ + + G +W+L H Sbjct: 537 KILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSL--------QTFTCLVGYKGHNYPV 588 Query: 224 LQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQ 283 +FSP + D+ ++W T ++ + + + + F +S Sbjct: 589 WDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLAD--------VNCTRFHPNSN 640 Query: 284 YIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDS 323 Y+ T S+D RLW V G R + GH+ + L F+ + Sbjct: 641 YVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPN 680 >1VYH-C nrPDB Length = 410 Score = 206 bits (525), Expect = 9e-54, Method: Composition-based stats. Identities = 49/311 (15%), Positives = 111/311 (35%), Gaps = 42/311 (13%) Query: 35 TRTVQHQDSQVNALEVTPDRSMIAAAGYQ-HIRMYDLNSNNPNPIISYDGVNKNIASVGF 93 + S V + P S++ +A I+++D + + + G ++ + F Sbjct: 101 KYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFER--TLKGHTDSVQDISF 158 Query: 94 HEDGRWMYTGGEDCTARIWDLRSRNLQCQRI-FQVNAPINCVCLHPNQAELIVGDQSGAI 152 G+ + + D T ++WD + +C R + ++ V + PN ++ + I Sbjct: 159 DHSGKLLASCSADMTIKLWDFQG--FECIRTMHGHDHNVSSVSIMPNGDHIVSASRDKTI 216 Query: 153 HIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIP 212 +W+++T + + + + D + +A+ ++ VW V Sbjct: 217 KMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVW--------VVATKEC 268 Query: 213 KTKIPAHTRYALQCRFSPD--------------------STLLATCSADQTCKIWRTSNF 252 K ++ H ++P+ L + S D+T K+W S Sbjct: 269 KAELREHRHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTG 328 Query: 253 SLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQ 312 + L W+ G F ++I++ + D R+W + + H+ Sbjct: 329 MCLMTLV--------GHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHE 380 Query: 313 KAVVCLAFNDS 323 V L F+ + Sbjct: 381 HFVTSLDFHKT 391 Score = 203 bits (516), Expect = 9e-53, Method: Composition-based stats. Identities = 45/309 (14%), Positives = 108/309 (34%), Gaps = 42/309 (13%) Query: 14 ILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQ-HIRMYDLNS 72 ++ +A D T++ W +G RT++ V + ++A+ I+++D Sbjct: 122 VMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQG 181 Query: 73 NNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIF-QVNAPI 131 I + G + N++SV +G + + D T ++W++++ C + F + Sbjct: 182 FEC--IRTMHGHDHNVSSVSIMPNGDHIVSASRDKTIKMWEVQTG--YCVKTFTGHREWV 237 Query: 132 NCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPD---------- 181 V + + + + +W + T + + E + P+ Sbjct: 238 RMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHRHVVECISWAPESSYSSISEAT 297 Query: 182 ----------ASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPD 231 ++ + + +W+++ G + + H + F Sbjct: 298 GSETKKSGKPGPFLLSGSRDKTIKMWDVSTG--------MCLMTLVGHDNWVRGVLFHSG 349 Query: 232 STLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSD 291 + +C+ D+T ++W N M L+ + F + Y+VT S D Sbjct: 350 GKFILSCADDKTLRVWDYKNKRCMKTLNAHEHF--------VTSLDFHKTAPYVVTGSVD 401 Query: 292 NLARLWCVE 300 ++W Sbjct: 402 QTVKVWECR 410 Score = 183 bits (463), Expect = 1e-46, Method: Composition-based stats. Identities = 43/260 (16%), Positives = 95/260 (36%), Gaps = 32/260 (12%) Query: 12 PVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAG-YQHIRMYDL 70 +LA+ D T++ W C RT+ D V+++ + P+ I +A + I+M+++ Sbjct: 162 GKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVSIMPNGDHIVSASRDKTIKMWEV 221 Query: 71 NSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAP 130 + + ++ G + + V ++DG + + D T R+W + ++ + + + + Sbjct: 222 QTGYC--VKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAE-LREHRHV 278 Query: 131 INCVCLHPN--------------------QAELIVGDQSGAIHIWDLKTDHNEQLIPEPE 170 + C+ P L+ G + I +WD+ T + + Sbjct: 279 VECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHD 338 Query: 171 VSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSP 230 + ++ + VW+ + AH + F Sbjct: 339 NWVRGVLFHSGGKFILSCADDKTLRVWDYKNK--------RCMKTLNAHEHFVTSLDFHK 390 Query: 231 DSTLLATCSADQTCKIWRTS 250 + + T S DQT K+W Sbjct: 391 TAPYVVTGSVDQTVKVWECR 410 Score = 171 bits (434), Expect = 3e-43, Method: Composition-based stats. Identities = 45/260 (17%), Positives = 90/260 (34%), Gaps = 21/260 (8%) Query: 74 NPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINC 133 P + G + V FH M + ED T ++WD + + + + + + Sbjct: 97 RPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFE-RTLKGHTDSVQD 155 Query: 134 VCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGN 193 + + L I +WD + + + + +++S I P+ ++ + + Sbjct: 156 ISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVSIMPNGDHIVSASRDKT 215 Query: 194 CYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFS 253 +W + G H + R + D TL+A+CS DQT ++W + Sbjct: 216 IKMWEVQTG--------YCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKE 267 Query: 254 LMTELSIKSGNPGESSRGWMWGCAFSGD------------SQYIVTASSDNLARLWCVET 301 EL S + + ++++ S D ++W V T Sbjct: 268 CKAELREHRHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVST 327 Query: 302 GEIKREYGGHQKAVVCLAFN 321 G GH V + F+ Sbjct: 328 GMCLMTLVGHDNWVRGVLFH 347 Score = 143 bits (360), Expect = 1e-34, Method: Composition-based stats. Identities = 33/217 (15%), Positives = 76/217 (35%), Gaps = 24/217 (11%) Query: 2 NTSPGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAG 61 N S ++ + + +A D T++ W+ +G C +T V + D ++IA+ Sbjct: 194 NVSSVSIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCS 253 Query: 62 -YQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHED--------------------GRWM 100 Q +R++ + + + + + + G ++ Sbjct: 254 NDQTVRVWVVATKECKA--ELREHRHVVECISWAPESSYSSISEATGSETKKSGKPGPFL 311 Query: 101 YTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTD 160 +G D T ++WD+ + + + + + V H ++ + +WD K Sbjct: 312 LSGSRDKTIKMWDVSTG-MCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNK 370 Query: 161 HNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVW 197 + + E +TS A Y+ + VW Sbjct: 371 RCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVW 407 Score = 54.0 bits (128), Expect = 8e-08, Method: Composition-based stats. Identities = 16/65 (24%), Positives = 27/65 (41%) Query: 259 SIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCL 318 R + F +V+AS D ++W ETG+ +R GH +V + Sbjct: 97 RPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDI 156 Query: 319 AFNDS 323 +F+ S Sbjct: 157 SFDHS 161 >5FL8-q nrPDB Length = 515 Score = 201 bits (512), Expect = 2e-52, Method: Composition-based stats. Identities = 59/322 (18%), Positives = 122/322 (37%), Gaps = 30/322 (9%) Query: 9 GSDPVILATAGYDHTVRFWQAHSGICTRT-VQHQDSQVNALEVTP-------DRSMIAAA 60 D ++AT D+T+R W SG C ++ + +L P + +A++ Sbjct: 195 SPDGEVIATGSMDNTIRLWDPKSGQCLGDALRGHSKWITSLSWEPIHLVKPGSKPRLASS 254 Query: 61 GYQ-HIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNL 119 I+++D S +S G +++ V + G +Y+G D T R+WD+ S+ Sbjct: 255 SKDGTIKIWDTVSRVCQYTMS--GHTNSVSCVKWGGQG-LLYSGSHDRTVRVWDINSQGR 311 Query: 120 QCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHID 179 + +N + L + A I G + ++ + E Sbjct: 312 CINILKSHAHWVNHLSLSTDYALRI-GAFDHTGKKPSTPEEAQKKALENYEKICKKNGNS 370 Query: 180 PDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCS 239 + M + ++WN P ++ H + FSPD + + S Sbjct: 371 EE--MMVTASDDYTMFLWNPLKSTK-------PIARMTGHQKLVNHVAFSPDGRYIVSAS 421 Query: 240 ADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCV 299 D + K+W + ++ + ++ A+S D + +V+ S D ++W V Sbjct: 422 FDNSIKLWDGRDGKFISTFRGHVAS--------VYQVAWSSDCRLLVSCSKDTTLKVWDV 473 Query: 300 ETGEIKREYGGHQKAVVCLAFN 321 T ++ + GH+ V + ++ Sbjct: 474 RTRKLSVDLPGHKDEVYTVDWS 495 Score = 154 bits (390), Expect = 4e-38, Method: Composition-based stats. Identities = 37/272 (13%), Positives = 81/272 (29%), Gaps = 48/272 (17%) Query: 15 LATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLNSNN 74 LA++ D T++ W S +C T+ + V+ ++ + + + + +R++D+NS Sbjct: 251 LASSSKDGTIKIWDTVSRVCQYTMSGHTNSVSCVKWGGQGLLYSGSHDRTVRVWDINS-Q 309 Query: 75 PNPIISYDGVNKNIASVGFHED-------------------------------------- 96 I + + D Sbjct: 310 GRCINILKSHAHWVNHLSLSTDYALRIGAFDHTGKKPSTPEEAQKKALENYEKICKKNGN 369 Query: 97 -GRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIW 155 M T +D T +W+ R+ +N V P+ ++ +I +W Sbjct: 370 SEEMMVTASDDYTMFLWNPLKSTKPIARMTGHQKLVNHVAFSPDGRYIVSASFDNSIKLW 429 Query: 156 DLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTK 215 D + S+ D + + + VW++ Sbjct: 430 DGRDGKFISTFRGHVASVYQVAWSSDCRLLVSCSKDTTLKVWDVRTRKLS--------VD 481 Query: 216 IPAHTRYALQCRFSPDSTLLATCSADQTCKIW 247 +P H +S D + + D+ ++W Sbjct: 482 LPGHKDEVYTVDWSVDGKRVCSGGKDKMVRLW 513 Score = 140 bits (352), Expect = 9e-34, Method: Composition-based stats. Identities = 54/282 (19%), Positives = 91/282 (32%), Gaps = 52/282 (18%) Query: 83 GVNKNIASVGFHE-DGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQA 141 G I F M TG D TARIWD ++ + + CV P+ Sbjct: 141 GHGSTILCSAFAPHTSSRMVTGAGDNTARIWDCDTQTPMH-TLKGHYNWVLCVSWSPDGE 199 Query: 142 ELIVGDQSGAIHIWDLKTDHNEQL-IPEPEVSITSAHIDP-------DASYMAAVNSTGN 193 + G I +WD K+ + ITS +P +A+ + G Sbjct: 200 VIATGSMDNTIRLWDPKSGQCLGDALRGHSKWITSLSWEPIHLVKPGSKPRLASSSKDGT 259 Query: 194 CYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSN-F 252 +W+ + + + HT ++ LL + S D+T ++W ++ Sbjct: 260 IKIWDTVSR--------VCQYTMSGHTNSVSCVKWGGQG-LLYSGSHDRTVRVWDINSQG 310 Query: 253 SLMTELSIKSGNPGESSRGWMWGC---AFSGDSQ-------------------------- 283 + L + S + AF + Sbjct: 311 RCINILKSHAHWVNHLSLSTDYALRIGAFDHTGKKPSTPEEAQKKALENYEKICKKNGNS 370 Query: 284 --YIVTASSDNLARLWC-VETGEIKREYGGHQKAVVCLAFND 322 +VTAS D LW +++ + GHQK V +AF+ Sbjct: 371 EEMMVTASDDYTMFLWNPLKSTKPIARMTGHQKLVNHVAFSP 412 Score = 123 bits (309), Expect = 1e-28, Method: Composition-based stats. Identities = 35/221 (15%), Positives = 69/221 (31%), Gaps = 25/221 (11%) Query: 111 IWDLRSRNLQCQRIFQVNAPINCVCLHPN-QAELIVGDQSGAIHIWDLKTDHNEQLIPEP 169 ++ ++ I + I C P+ + ++ G IWD T + Sbjct: 126 VFKVKPVTRSSSAIAGHGSTILCSAFAPHTSSRMVTGAGDNTARIWDCDTQTPMHTLKGH 185 Query: 170 EVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFS 229 + PD +A + +W+ G + H+++ + Sbjct: 186 YNWVLCVSWSPDGEVIATGSMDNTIRLWDPKSG-------QCLGDALRGHSKWITSLSWE 238 Query: 230 P-------DSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDS 282 P LA+ S D T KIW T + +S + + + + G Sbjct: 239 PIHLVKPGSKPRLASSSKDGTIKIWDTVSRVCQYTMSGHTNS--------VSCVKWGGQG 290 Query: 283 QYIVTASSDNLARLWCVET-GEIKREYGGHQKAVVCLAFND 322 + + S D R+W + + G H V L+ + Sbjct: 291 -LLYSGSHDRTVRVWDINSQGRCINILKSHAHWVNHLSLST 330 Score = 58.2 bits (139), Expect = 5e-09, Method: Composition-based stats. Identities = 10/61 (16%), Positives = 26/61 (42%), Gaps = 1/61 (1%) Query: 9 GSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQH-IRM 67 SD +L + D T++ W + + + +V ++ + D + + G +R+ Sbjct: 453 SSDCRLLVSCSKDTTLKVWDVRTRKLSVDLPGHKDEVYTVDWSVDGKRVCSGGKDKMVRL 512 Query: 68 Y 68 + Sbjct: 513 W 513 >6HQA-B nrPDB Length = 722 Score = 201 bits (511), Expect = 4e-52, Method: Composition-based stats. Identities = 49/279 (17%), Positives = 102/279 (36%), Gaps = 34/279 (12%) Query: 9 GSDPVILATAGYDHTVRFWQAH------------------SGICT---RTVQHQDSQVNA 47 D ++A+ D ++ W G+ R + V Sbjct: 399 NDDSTMVASGFQDSFIKLWSIDGSPLRSLLKNDPYNQQNNDGVAVKGSRRLVGHSGAVYG 458 Query: 48 LEVTPDRSMIAAAGYQ-HIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGED 106 ++ +PD + + +R++ L++ ++SY G + ++ V F G + T D Sbjct: 459 VDFSPDNRYLISCSEDKTVRLWSLDTYTC--LVSYKGHSSSVWDVKFSPMGHYFATASHD 516 Query: 107 CTARIWDLRSRNLQCQRIFQVN-APINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQL 165 TAR+W ++ RIF + ++CV HPN L G +WD+ ++ Sbjct: 517 QTARLWSCD--HIYPLRIFAGHLNDVDCVEFHPNSTYLFTGSSDKTARMWDIARGECVRV 574 Query: 166 IPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQ 225 +I + PD ++A+ +W+++ G + + + Sbjct: 575 FMGHSGAINCLAVSPDGRWLASAGEDSVVCLWDISTGRRIKAMRGHGR-------SSIYS 627 Query: 226 CRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGN 264 FS + T+L + AD + ++W + + N Sbjct: 628 LAFSREGTVLVSTGADNSVRVWDVKKNTNSPSAQPEPIN 666 Score = 188 bits (477), Expect = 3e-48, Method: Composition-based stats. Identities = 47/288 (16%), Positives = 100/288 (34%), Gaps = 36/288 (12%) Query: 33 ICTRTVQHQDSQVNALEVTPDRSMIAAAGYQH-IRMYDLNSNNPNPIISYD--------- 82 +C T + ++ + L+ D +M+A+ I+++ ++ + ++ D Sbjct: 381 VCMYTFHNTNNDLTCLKFNDDSTMVASGFQDSFIKLWSIDGSPLRSLLKNDPYNQQNNDG 440 Query: 83 ----------GVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPIN 132 G + + V F D R++ + ED T R+W L + ++ + Sbjct: 441 VAVKGSRRLVGHSGAVYGVDFSPDNRYLISCSEDKTVRLWSLDTYTCLVSYK-GHSSSVW 499 Query: 133 CVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTG 192 V P +W + ++ + P+++Y+ +S Sbjct: 500 DVKFSPMGHYFATASHDQTARLWSCDHIYPLRIFAGHLNDVDCVEFHPNSTYLFTGSSDK 559 Query: 193 NCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNF 252 +W++ G V H+ SPD LA+ D +W S Sbjct: 560 TARMWDIARGECVRVFM--------GHSGAINCLAVSPDGRWLASAGEDSVVCLWDISTG 611 Query: 253 SLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVE 300 + + R ++ AFS + +V+ +DN R+W V+ Sbjct: 612 RRIKAMRGHG-------RSSIYSLAFSREGTVLVSTGADNSVRVWDVK 652 Score = 183 bits (464), Expect = 9e-47, Method: Composition-based stats. Identities = 50/283 (17%), Positives = 102/283 (36%), Gaps = 38/283 (13%) Query: 61 GYQHIRMYDLNSNNP-NPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNL 119 I++ ++ P + ++ N ++ + F++D + +G +D ++W + L Sbjct: 365 SRAKIKLSAAQASLPSVCMYTFHNTNNDLTCLKFNDDSTMVASGFQDSFIKLWSIDGSPL 424 Query: 120 QC--------------------QRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKT 159 + +R+ + + V P+ LI + + +W L T Sbjct: 425 RSLLKNDPYNQQNNDGVAVKGSRRLVGHSGAVYGVDFSPDNRYLISCSEDKTVRLWSLDT 484 Query: 160 DHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAH 219 S+ P Y A + +W+ + P H Sbjct: 485 YTCLVSYKGHSSSVWDVKFSPMGHYFATASHDQTARLWSCDH--------IYPLRIFAGH 536 Query: 220 TRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFS 279 F P+ST L T S+D+T ++W + + SG + A S Sbjct: 537 LNDVDCVEFHPNSTYLFTGSSDKTARMWDIARGECVRVFMGHSGA--------INCLAVS 588 Query: 280 GDSQYIVTASSDNLARLWCVETGEIKREYGGH-QKAVVCLAFN 321 D +++ +A D++ LW + TG + GH + ++ LAF+ Sbjct: 589 PDGRWLASAGEDSVVCLWDISTGRRIKAMRGHGRSSIYSLAFS 631 Score = 152 bits (385), Expect = 1e-37, Method: Composition-based stats. Identities = 48/229 (20%), Positives = 79/229 (34%), Gaps = 38/229 (16%) Query: 116 SRNLQCQRIFQV-NAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIP------- 167 S C F N + C+ + + + G Q I +W + L+ Sbjct: 377 SLPSVCMYTFHNTNNDLTCLKFNDDSTMVASGFQDSFIKLWSIDGSPLRSLLKNDPYNQQ 436 Query: 168 --------------EPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPK 213 ++ PD Y+ + + +W+L Sbjct: 437 NNDGVAVKGSRRLVGHSGAVYGVDFSPDNRYLISCSEDKTVRLWSLDTYT--------CL 488 Query: 214 TKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWM 273 H+ +FSP AT S DQT ++W + + L I +G+ + Sbjct: 489 VSYKGHSSSVWDVKFSPMGHYFATASHDQTARLWSCDH---IYPLRIFAGHLNDVD---- 541 Query: 274 WGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFND 322 F +S Y+ T SSD AR+W + GE R + GH A+ CLA + Sbjct: 542 -CVEFHPNSTYLFTGSSDKTARMWDIARGECVRVFMGHSGAINCLAVSP 589 Score = 112 bits (279), Expect = 2e-25, Method: Composition-based stats. Identities = 36/177 (20%), Positives = 65/177 (36%), Gaps = 21/177 (11%) Query: 162 NEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIP--------- 212 +T + D++ +A+ +W++ G + + P Sbjct: 382 CMYTFHNTNNDLTCLKFNDDSTMVASGFQDSFIKLWSIDGSPLRSLLKNDPYNQQNNDGV 441 Query: 213 ----KTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGES 268 ++ H+ FSPD+ L +CS D+T ++W ++ + S + Sbjct: 442 AVKGSRRLVGHSGAVYGVDFSPDNRYLISCSEDKTVRLWSLDTYTCLVSYKGHSSS---- 497 Query: 269 SRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDSVL 325 +W FS Y TAS D ARLW + R + GH V C+ F+ + Sbjct: 498 ----VWDVKFSPMGHYFATASHDQTARLWSCDHIYPLRIFAGHLNDVDCVEFHPNST 550 Score = 53.6 bits (127), Expect = 1e-07, Method: Composition-based stats. Identities = 16/72 (22%), Positives = 34/72 (47%), Gaps = 2/72 (2%) Query: 8 VGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQD-SQVNALEVTPDRS-MIAAAGYQHI 65 V D LA+AG D V W +G + ++ S + +L + + + +++ + Sbjct: 587 VSPDGRWLASAGEDSVVCLWDISTGRRIKAMRGHGRSSIYSLAFSREGTVLVSTGADNSV 646 Query: 66 RMYDLNSNNPNP 77 R++D+ N +P Sbjct: 647 RVWDVKKNTNSP 658 >6ID0-T nrPDB Length = 514 Score = 200 bits (509), Expect = 5e-52, Method: Composition-based stats. Identities = 53/284 (18%), Positives = 98/284 (34%), Gaps = 14/284 (4%) Query: 15 LATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQH-IRMYDLNSN 73 T D T++ W SG ++ S V + V+ + + G ++ +DL N Sbjct: 219 FVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYN 278 Query: 74 NPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINC 133 I Y G + + H + T D TARIWD+R++ + + Sbjct: 279 KV--IRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKAS-VHTLSGHTNAVAT 335 Query: 134 VCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGN 193 V + ++I G I +WDL + + S+ + + P Y A S N Sbjct: 336 VRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHP-RHYTFASGSPDN 394 Query: 194 CYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFS 253 W G + + H + D +L + + + T +W Sbjct: 395 IKQWKFPDGSFIQ--------NLSGHNAIINTLTVNSDG-VLVSGADNGTMHLWDWRTGY 445 Query: 254 LMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLW 297 + S ++ CAF ++TA +D +++ Sbjct: 446 NFQRVHAAVQPGSLDSESGIFACAFDQSESRLLTAEADKTIKVY 489 Score = 161 bits (406), Expect = 4e-40, Method: Composition-based stats. Identities = 48/303 (15%), Positives = 95/303 (31%), Gaps = 30/303 (9%) Query: 32 GICTRTVQHQDSQVNALEVTPDRSMIAAAG-YQHIRMYDLNSNNPNPIISYDGVNKNIAS 90 R + V + V P + I+++DL S +S G + Sbjct: 194 WKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLK--LSLTGHISTVRG 251 Query: 91 VGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSG 150 V ++++ GED + WDL N + + + + LHP L+ + Sbjct: 252 VIVSTRSPYLFSCGEDKQVKCWDLE-YNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDS 310 Query: 151 AIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQL 210 IWD++T + + ++ + + + +W+L G Sbjct: 311 TARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKT------ 364 Query: 211 IPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSR 270 + + H + P A+ S D K W+ + S + LS Sbjct: 365 --RVTLTNHKKSVRAVVLHPRHYTFASGSPDN-IKQWKFPDGSFIQNLS--------GHN 413 Query: 271 GWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGG--------HQKAVVCLAFND 322 + + D +V+ + + LW TG + + + AF+ Sbjct: 414 AIINTLTVNSDG-VLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQ 472 Query: 323 SVL 325 S Sbjct: 473 SES 475 Score = 145 bits (365), Expect = 3e-35, Method: Composition-based stats. Identities = 46/251 (18%), Positives = 83/251 (33%), Gaps = 6/251 (2%) Query: 8 VGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQ-HIR 66 V + L + G D V+ W R S V L++ P ++ R Sbjct: 254 VSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTAR 313 Query: 67 MYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQ 126 ++D+ + + + G +A+V + TG D T R+WDL + + Sbjct: 314 IWDVRT--KASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTN- 370 Query: 127 VNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMA 186 + V LHP G I W Q + I + ++ D + Sbjct: 371 HKKSVRAVVLHPRHYTFASGSPDN-IKQWKFPDGSFIQNLSGHNAIINTLTVNSDG-VLV 428 Query: 187 AVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKI 246 + G ++W+ G + + C F + L T AD+T K+ Sbjct: 429 SGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESRLLTAEADKTIKV 488 Query: 247 WRTSNFSLMTE 257 +R + + Sbjct: 489 YREDDTATEET 499 Score = 60.2 bits (144), Expect = 1e-09, Method: Composition-based stats. Identities = 22/166 (13%), Positives = 44/166 (26%), Gaps = 51/166 (30%) Query: 15 LATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLNSNN 74 + T +D T+R W +G T+ + V A+ + P A+ +I+ + + Sbjct: 345 IITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDNIKQWKFPDGS 404 Query: 75 PNPIISYDGVNKNIASVGFHEDG------------------------------------- 97 +S G N I ++ + DG Sbjct: 405 FIQNLS--GHNAIINTLTVNSDGVLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSE 462 Query: 98 ------------RWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPI 131 + T D T +++ + I Sbjct: 463 SGIFACAFDQSESRLLTAEADKTIKVYREDDTATEETHPVSWKPEI 508 >3JAP-g nrPDB Length = 326 Score = 198 bits (504), Expect = 2e-51, Method: Composition-based stats. Identities = 63/319 (19%), Positives = 106/319 (33%), Gaps = 32/319 (10%) Query: 3 TSPGTVGSDPVILATAGYDHTVRFWQAHS-----GICTRTVQHQDSQVNALEVTPDRSMI 57 TS T + P +L + D T+ W+ G+ R+ + V + V+ D + Sbjct: 22 TSLSTSAAQPNLLVSGSRDKTLISWRLTENEQQFGVPVRSYKGHSHIVQDVVVSADGNYA 81 Query: 58 AAAGYQ-HIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRS 116 +A + +R+++L + N + G ++ SV + + + D T R+W+ Sbjct: 82 VSASWDKTLRLWNLATGNSEA--RFVGHTGDVLSVAIDANSSKIISASRDKTIRVWNTVG 139 Query: 117 RNLQCQRIFQVNAPINCVCLHPNQAE----------LIVGDQSGAIHIWDLKTD--HNEQ 164 + + V + P E + + W L D E Sbjct: 140 DCAYV--LLGHTDWVTKVRVAPKNLEDGEVDDGRITFVSAGMDKIVRSWSLNEDSYRIEA 197 Query: 165 LIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYAL 224 I PD S A+ G YVWNL Sbjct: 198 DFIGHNNYINVVQPSPDGSLAASAGKDGQIYVWNLKHKSAFMNF---------DAKDEVF 248 Query: 225 QCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQY 284 FSP L +A KI+ N L+ EL + ++ A+S D Q Sbjct: 249 ALAFSPSRFWLTAATASG-IKIYDLENEVLIDELKPEFAGYTKAQDPHAVSLAWSADGQT 307 Query: 285 IVTASSDNLARLWCVETGE 303 + +DN+ R+W V T Sbjct: 308 LFAGYTDNVIRVWQVMTAN 326 Score = 124 bits (311), Expect = 6e-29, Method: Composition-based stats. Identities = 39/259 (15%), Positives = 86/259 (33%), Gaps = 31/259 (11%) Query: 80 SYDGVNKNIASVGFHEDG-RWMYTGGEDCTARIW----DLRSRNLQCQRIFQVNAPINCV 134 + +G N + S+ + +G D T W + + + + + + V Sbjct: 13 TLEGHNGWVTSLSTSAAQPNLLVSGSRDKTLISWRLTENEQQFGVPVRSYKGHSHIVQDV 72 Query: 135 CLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNC 194 + + + + +W+L T ++E + S ID ++S + + + Sbjct: 73 VVSADGNYAVSASWDKTLRLWNLATGNSEARFVGHTGDVLSVAIDANSSKIISASRDKTI 132 Query: 195 YVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSP---------DSTL-LATCSADQTC 244 VWN G + HT + + R +P D + + D+ Sbjct: 133 RVWNTVG---------DCAYVLLGHTDWVTKVRVAPKNLEDGEVDDGRITFVSAGMDKIV 183 Query: 245 KIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEI 304 + W + I++ G + ++ S D +A D +W ++ Sbjct: 184 RSWSLN----EDSYRIEADFIGHN--NYINVVQPSPDGSLAASAGKDGQIYVWNLKHKSA 237 Query: 305 KREYGGHQKAVVCLAFNDS 323 + + V LAF+ S Sbjct: 238 FMNFDA-KDEVFALAFSPS 255 Score = 66.3 bits (160), Expect = 2e-11, Method: Composition-based stats. Identities = 32/168 (19%), Positives = 62/168 (36%), Gaps = 14/168 (8%) Query: 2 NTSPGTVGSDPVILATAGYDHTVRFWQA--HSGICTRTVQHQDSQVNALEVTPDRSMIAA 59 N G V + +AG D VR W S ++ +N ++ +PD S+ A+ Sbjct: 161 NLEDGEVDDGRITFVSAGMDKIVRSWSLNEDSYRIEADFIGHNNYINVVQPSPDGSLAAS 220 Query: 60 AGYQ-HIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRN 118 AG I +++L + + +++D + ++ F R+ T +I+DL + Sbjct: 221 AGKDGQIYVWNLK--HKSAFMNFDA-KDEVFALAFSPS-RFWLTAATASGIKIYDLENEV 276 Query: 119 L-------QCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKT 159 L + + + L G I +W + T Sbjct: 277 LIDELKPEFAGYTKAQDPHAVSLAWSADGQTLFAGYTDNVIRVWQVMT 324 >5WYK-BB nrPDB Length = 943 Score = 198 bits (502), Expect = 4e-51, Method: Composition-based stats. Identities = 60/306 (19%), Positives = 117/306 (38%), Gaps = 36/306 (11%) Query: 8 VGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQ-HIR 66 + D +LATA + +++ W + C RT + + P ++ ++ Sbjct: 399 ISDDNKLLATAS-NGSLKIWNIKTHKCIRTFEC--GYALTCKFLPGGLLVILGTRNGELQ 455 Query: 67 MYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRN-------- 118 ++DL S++ I D + I S+ DG+ + TG D T + WD + N Sbjct: 456 LFDLASSSLLDTIE-DAHDAAIWSLDLTSDGKRLVTGSADKTVKFWDFKVENSLVPGTKN 514 Query: 119 -------LQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEV 171 L ++ I CV + P+ L + + ++ L + + ++ Sbjct: 515 KFLPVLKLHHDTTLELTDDILCVRVSPDDRYLAISLLDNTVKVFFLDSMKFYLSLYGHKL 574 Query: 172 SITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPD 231 + S I D+ + ++ N +W L G + AH + +F P Sbjct: 575 PVLSIDISFDSKMIITSSADKNIKIWGLDFG--------DCHKSLFAHQDSIMNVKFLPQ 626 Query: 232 STLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSD 291 S +CS D K W F + +L + + +W A + D ++V++S D Sbjct: 627 SHNFFSCSKDAVVKYWDGEKFECIQKLY--------AHQSEVWALAVATDGGFVVSSSHD 678 Query: 292 NLARLW 297 + R+W Sbjct: 679 HSIRIW 684 Score = 143 bits (360), Expect = 1e-34, Method: Composition-based stats. Identities = 54/298 (18%), Positives = 106/298 (35%), Gaps = 36/298 (12%) Query: 38 VQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDG 97 +Q Q + V +++++ D ++A A ++++++ ++ I +++ + F G Sbjct: 387 LQGQRTDVRSIDISDDNKLLATASNGSLKIWNIKTHKC--IRTFE--CGYALTCKFLPGG 442 Query: 98 RWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDL 157 + G + +++DL S +L +A I + L + L+ G + WD Sbjct: 443 LLVILGTRNGELQLFDLASSSLLDTIEDAHDAAIWSLDLTSDGKRLVTGSADKTVKFWDF 502 Query: 158 K---------TDHNEQLIPEPEVS-------ITSAHIDPDASYMAAVNSTGNCYVWNLTG 201 K + ++ + I + PD Y+A V+ L Sbjct: 503 KVENSLVPGTKNKFLPVLKLHHDTTLELTDDILCVRVSPDDRYLAISLLDNTVKVFFLDS 562 Query: 202 GIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIK 261 + + H L S DS ++ T SAD+ KIW L Sbjct: 563 --------MKFYLSLYGHKLPVLSIDISFDSKMIITSSADKNIKIWGLDFGDCHKSL--- 611 Query: 262 SGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLA 319 + + + F S + S D + + W E E ++ HQ V LA Sbjct: 612 -----FAHQDSIMNVKFLPQSHNFFSCSKDAVVKYWDGEKFECIQKLYAHQSEVWALA 664 Score = 139 bits (351), Expect = 1e-33, Method: Composition-based stats. Identities = 54/310 (17%), Positives = 114/310 (36%), Gaps = 30/310 (9%) Query: 29 AHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLNSNNPNPI---------I 79 H R++ S + ++ I Y + +P I Sbjct: 326 LHPFQTIRSLYKIKSASWTTVSSSKLELVLTTSSNTIEYYSIPYEKRDPTSPAPLKTHTI 385 Query: 80 SYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPN 139 G ++ S+ +D + + T + +IW++++ +C R F+ + C P Sbjct: 386 ELQGQRTDVRSIDISDDNKLLATASN-GSLKIWNIKTH--KCIRTFECGYALTC-KFLPG 441 Query: 140 QAELIVGDQSGAIHIWDLKTDHNEQLI-PEPEVSITSAHIDPDASYMAAVNSTGNCYVWN 198 +I+G ++G + ++DL + I + +I S + D + ++ W+ Sbjct: 442 GLLVILGTRNGELQLFDLASSSLLDTIEDAHDAAIWSLDLTSDGKRLVTGSADKTVKFWD 501 Query: 199 LT---GGIGDEVTQLIPKTKIPAHT-----RYALQCRFSPDSTLLATCSADQTCKIWRTS 250 + + +P K+ T L R SPD LA D T K++ Sbjct: 502 FKVENSLVPGTKNKFLPVLKLHHDTTLELTDDILCVRVSPDDRYLAISLLDNTVKVFFLD 561 Query: 251 NFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGG 310 + L + + S DS+ I+T+S+D ++W ++ G+ + Sbjct: 562 SMKFYLSLY--------GHKLPVLSIDISFDSKMIITSSADKNIKIWGLDFGDCHKSLFA 613 Query: 311 HQKAVVCLAF 320 HQ +++ + F Sbjct: 614 HQDSIMNVKF 623 Score = 96.4 bits (238), Expect = 2e-20, Method: Composition-based stats. Identities = 43/352 (12%), Positives = 99/352 (28%), Gaps = 57/352 (16%) Query: 7 TVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQ-HI 65 D +LA D ++ W S + + L+ + + + +I Sbjct: 86 EAHKDTDLLAVGYADGVIKVWDLMSKTVLLNFNGHKAAITLLQFDGTGTRLISGSKDSNI 145 Query: 66 RMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIF 125 ++DL + +I + + W+ + +D ++WDL++ QC Sbjct: 146 IVWDLVG--EVGLYKLRSHKDSITGF-WCQGEDWLISTSKDGMIKLWDLKT--HQCIETH 200 Query: 126 -QVNAPINCVCLHPNQAELIVGDQSGAIHIW--DLKTDH----------NEQLIPEPEVS 172 + + + LI + IW D++ D E+ + + Sbjct: 201 IAHTGECWGLAVKDD--LLITTGTDSQVKIWKLDIENDKMGGKLTEMGIFEKQSKQRGLK 258 Query: 173 ITSAHIDPDA-SYMAAVNSTGNCYVWNLTG-----------GIGDEVTQLIPKTKIPAHT 220 I D S+ N+ + + + L + + Sbjct: 259 IEFITNSSDKTSFFYIQNADKTIETFRIRKEEEIARGLKKREKRLKEKGLTEEEIAKSIK 318 Query: 221 RYALQCRFSPDSTL-----LATCSA---------------DQTCKIWRTSNFSLMTELSI 260 P T+ + + S T + + Sbjct: 319 ESYSSFILHPFQTIRSLYKIKSASWTTVSSSKLELVLTTSSNTIEYYSIPYEKRDPTSPA 378 Query: 261 KSGNPG---ESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYG 309 + R + S D++ + TAS + ++W ++T + R + Sbjct: 379 PLKTHTIELQGQRTDVRSIDISDDNKLLATAS-NGSLKIWNIKTHKCIRTFE 429 Score = 95.2 bits (235), Expect = 3e-20, Method: Composition-based stats. Identities = 42/215 (19%), Positives = 75/215 (34%), Gaps = 32/215 (14%) Query: 94 HEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQ---------VNAPINC--VCLHPNQAE 142 G+ + + ED IWD+++ +L + P C + H + Sbjct: 36 SGPGQLITSALED--VNIWDIKTGDLVSKLSDGLPPGASDARGAKPAECTYLEAHKDTDL 93 Query: 143 LIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGG 202 L VG G I +WDL + + +IT D + + + + N VW+L G Sbjct: 94 LAVGYADGVIKVWDLMSKTVLLNFNGHKAAITLLQFDGTGTRLISGSKDSNIIVWDLVGE 153 Query: 203 IGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKS 262 +G K+ +H + L + S D K+W + Sbjct: 154 VG--------LYKLRSHKDSITGF-WCQGEDWLISTSKDGMIKLWDLKTHQCIET----- 199 Query: 263 GNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLW 297 + G WG A D ++T +D+ ++W Sbjct: 200 ---HIAHTGECWGLAVKDD--LLITTGTDSQVKIW 229 Score = 92.5 bits (228), Expect = 2e-19, Method: Composition-based stats. Identities = 26/156 (16%), Positives = 64/156 (41%), Gaps = 6/156 (3%) Query: 8 VGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAG-YQHIR 66 V D LA + D+TV+ + S ++ V +++++ D MI + ++I+ Sbjct: 539 VSPDDRYLAISLLDNTVKVFFLDSMKFYLSLYGHKLPVLSIDISFDSKMIITSSADKNIK 598 Query: 67 MYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQR-IF 125 ++ L+ + S +I +V F ++ +D + WD +C + ++ Sbjct: 599 IWGLDFGDC--HKSLFAHQDSIMNVKFLPQSHNFFSCSKDAVVKYWD--GEKFECIQKLY 654 Query: 126 QVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDH 161 + + + + + ++ +I IW+ D Sbjct: 655 AHQSEVWALAVATDGGFVVSSSHDHSIRIWEETEDQ 690 Score = 90.6 bits (223), Expect = 9e-19, Method: Composition-based stats. Identities = 30/213 (14%), Positives = 69/213 (32%), Gaps = 20/213 (9%) Query: 119 LQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHI 178 + + + + + L +G++ IW++KT + + Sbjct: 382 THTIELQGQRTDVRSIDISDDNKLLATAS-NGSLKIWNIKTHKCIRTFEC--GYALTCKF 438 Query: 179 DPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATC 238 P + G +++L + + AH + D L T Sbjct: 439 LPGGLLVILGTRNGELQLFDLASSSLLDTIE-------DAHDAAIWSLDLTSDGKRLVTG 491 Query: 239 SADQTCKIWRT---------SNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTAS 289 SAD+T K W + + L + E + + S D +Y+ + Sbjct: 492 SADKTVKFWDFKVENSLVPGTKNKFLPVLKLHHDTTLELTDD-ILCVRVSPDDRYLAISL 550 Query: 290 SDNLARLWCVETGEIKREYGGHQKAVVCLAFND 322 DN +++ +++ + GH+ V+ + + Sbjct: 551 LDNTVKVFFLDSMKFYLSLYGHKLPVLSIDISF 583 Score = 82.9 bits (203), Expect = 2e-16, Method: Composition-based stats. Identities = 32/198 (16%), Positives = 59/198 (29%), Gaps = 31/198 (15%) Query: 140 QAELIVGDQSGAIHIWDLKTDHNEQLIPEP------------EVSITSAHIDPDASYMAA 187 + + ++IWD+KT + + T D +A Sbjct: 39 GQLITSALED--VNIWDIKTGDLVSKLSDGLPPGASDARGAKPAECTYLEAHKDTDLLAV 96 Query: 188 VNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIW 247 + G VW+L H +F T L + S D +W Sbjct: 97 GYADGVIKVWDLMSKT--------VLLNFNGHKAAITLLQFDGTGTRLISGSKDSNIIVW 148 Query: 248 RTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKRE 307 + +L + S W ++++ S D + +LW ++T + Sbjct: 149 DLVGEVGLYKLRSH-----KDSITGFWC----QGEDWLISTSKDGMIKLWDLKTHQCIET 199 Query: 308 YGGHQKAVVCLAFNDSVL 325 + H LA D +L Sbjct: 200 HIAHTGECWGLAVKDDLL 217 >3MKQ-A nrPDB Length = 814 Score = 184 bits (468), Expect = 3e-47, Method: Composition-based stats. Identities = 53/292 (18%), Positives = 103/292 (35%), Gaps = 20/292 (6%) Query: 9 GSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMY 68 ++P +L T Y V W + + R++Q ++ V A + ++ I R+ Sbjct: 23 PTEPWVLTTL-YSGRVEIWNYETQVEVRSIQVTETPVRAGKFIARKNWIIVGSDD-FRIR 80 Query: 69 DLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVN 128 N N ++ ++ I S+ H ++ +G +D T ++W+ + Q Sbjct: 81 VFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWNWENNWALEQTFEGHE 140 Query: 129 APINCVCLHP-NQAELIVGDQSGAIHIWDL-KTDHNEQLIPEPEVSITSAHI--DPDASY 184 + CV +P + + G + +W L ++ N L E + PD Y Sbjct: 141 HFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQERGVNYVDYYPLPDKPY 200 Query: 185 MAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTC 244 M + +W+ + H F P ++ + S D T Sbjct: 201 MITASDDLTIKIWDYQTKS--------CVATLEGHMSNVSFAVFHPTLPIIISGSEDGTL 252 Query: 245 KIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARL 296 KIW +S + + L++ R W +G YI + + L Sbjct: 253 KIWNSSTYKVEKTLNVGL------ERSWCIATHPTGRKNYIASGFDNGFTVL 298 Score = 159 bits (401), Expect = 2e-39, Method: Composition-based stats. Identities = 43/247 (17%), Positives = 86/247 (34%), Gaps = 14/247 (5%) Query: 79 ISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHP 138 ++ + + + FH W+ T IW+ ++ ++ + I P+ Sbjct: 7 KTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVEIWNYETQ-VEVRSIQVTETPVRAGKFIA 65 Query: 139 NQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWN 198 + +IVG I +++ T I S + P Y+ + + +WN Sbjct: 66 RKNWIIVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWN 125 Query: 199 LTGGIGDEVTQLIPKTKIPAHTRYALQCRFSP-DSTLLATCSADQTCKIWRTSNFSLMTE 257 E T H + + F+P D + A+ D+T K+W Sbjct: 126 WENNWALEQT-------FEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSL--GQSTPN 176 Query: 258 LSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVC 317 ++ +G + + D Y++TAS D ++W +T GH V Sbjct: 177 FTLTTGQERGVNYVDYYPL---PDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSF 233 Query: 318 LAFNDSV 324 F+ ++ Sbjct: 234 AVFHPTL 240 Score = 136 bits (343), Expect = 9e-33, Method: Composition-based stats. Identities = 46/294 (15%), Positives = 99/294 (33%), Gaps = 23/294 (7%) Query: 35 TRTVQHQDSQVNALEVTPDRSMIAAA-GYQHIRMYDLNSNNPNPIISYDGVNKNIASVGF 93 +T ++ +V ++ P + + +++ + + S + + F Sbjct: 6 KKTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVEIWNYETQ--VEVRSIQVTETPVRAGKF 63 Query: 94 HEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIH 153 W+ G +D R+++ + + I + +HP + ++ G + Sbjct: 64 IARKNWIIVGSDDFRIRVFNYNTGEKVVDFEAHPDY-IRSIAVHPTKPYVLSGSDDLTVK 122 Query: 154 IWDLKTD-HNEQLIPEPEVSITSAHIDP-DASYMAAVNSTGNCYVWNLTGGIGDEVTQLI 211 +W+ + + EQ E + +P D S A+ VW+L + Sbjct: 123 LWNWENNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNF----- 177 Query: 212 PKTKIPAHTRYALQCRF--SPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESS 269 T R + PD + T S D T KIW S + L E Sbjct: 178 --TLTTGQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATL--------EGH 227 Query: 270 RGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDS 323 + F I++ S D ++W T ++++ + C+A + + Sbjct: 228 MSNVSFAVFHPTLPIIISGSEDGTLKIWNSSTYKVEKTLNVGLERSWCIATHPT 281 Score = 64.8 bits (156), Expect = 5e-11, Method: Composition-based stats. Identities = 23/150 (15%), Positives = 44/150 (29%), Gaps = 35/150 (23%) Query: 208 TQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNF--------------- 252 +L K + F P + T +IW Sbjct: 1 MKLDIKKTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVEIWNYETQVEVRSIQVTETPVRA 60 Query: 253 ----------------SLMTELSIKSGNPG---ESSRGWMWGCAFSGDSQYIVTASSDNL 293 + + +G E+ ++ A Y+++ S D Sbjct: 61 GKFIARKNWIIVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLT 120 Query: 294 ARLWCVETG-EIKREYGGHQKAVVCLAFND 322 +LW E +++ + GH+ V+C+AFN Sbjct: 121 VKLWNWENNWALEQTFEGHEHFVMCVAFNP 150 Score = 57.1 bits (136), Expect = 1e-08, Method: Composition-based stats. Identities = 46/291 (15%), Positives = 90/291 (30%), Gaps = 23/291 (7%) Query: 2 NTSPGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDR--SMIAA 59 N S I+ + D T++ W + + +T+ + + P + IA+ Sbjct: 230 NVSFAVFHPTLPIIISGSEDGTLKIWNSSTYKVEKTLNVGLERSWCIATHPTGRKNYIAS 289 Query: 60 AGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNL 119 + L N P +S D V K + S G + ++T + +L Sbjct: 290 GFDNGFTVLSL--GNDEPTLSLDPVGKLVWSGGKNAAASDIFTAVIRGNEEVEQDEPLSL 347 Query: 120 QCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHID 179 Q + + V+ + PN + V G I+ N+ Sbjct: 348 QTKELGSVDVFPQSLAHSPNGRFVTVVG-DGEYVIYTALAWRNKAF-----GKCQDFVWG 401 Query: 180 PDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCS 239 PD++ A ++ TG T A+ FS LL S Sbjct: 402 PDSNSYALIDETGQIK----------YYKNFKEVTSWSVPMHSAIDRLFS--GALLGVKS 449 Query: 240 ADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASS 290 D + N +L+ + + + + S G + + + + + Sbjct: 450 -DGFVYFFDWDNGTLVRRIDVNAKDVIWSDNGELVMIVNTNSNGDEASGYT 499 >5Y88-O nrPDB Length = 451 Score = 183 bits (464), Expect = 9e-47, Method: Composition-based stats. Identities = 50/317 (15%), Positives = 107/317 (33%), Gaps = 20/317 (6%) Query: 11 DPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAA-AGYQHIRMYD 69 D T D T++ W +G T+ V + V+ + + + + ++ +D Sbjct: 151 DNEWFITGSNDTTMKVWDLATGKLKTTLAGHVMTVRDVAVSDRHPYLFSVSEDKTVKCWD 210 Query: 70 LNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNA 129 L N I Y G + +V H + T G D ++WD+R+R + + Sbjct: 211 LEKNQ--IIRDYYGHLSGVRTVSIHPTLDLIATAGRDSVIKLWDMRTR-IPVITLVGHKG 267 Query: 130 PINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVN 189 PIN V P +++ + +WD+ +++ + S+ + + P +A+ Sbjct: 268 PINQVQCTPVDPQVVSSSTDATVRLWDVVAGKTMKVLTHHKRSVRATALHPKEFSVASAC 327 Query: 190 STGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRT 249 + + W L G + T + D +L + + Sbjct: 328 TD-DIRSWGLAEGSLLTNFESEK-------TGIINTLSINQDD-VLFAGGDNGVLSFYDY 378 Query: 250 SNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYG 309 + L+ + + F ++T +D ++W + K Sbjct: 379 KSGHKYQSLATREMVGSLEGERSVLCSTFDKTGLRLITGEADKSIKIWKQDETATKESEP 438 Query: 310 GHQKAVVCLAFNDSVLG 326 G LA+N ++ Sbjct: 439 G-------LAWNPNLSA 448 Score = 140 bits (353), Expect = 7e-34, Method: Composition-based stats. Identities = 45/308 (14%), Positives = 105/308 (34%), Gaps = 33/308 (10%) Query: 27 WQAHSGICTRTVQHQDSQVNALEVTP-DRSMIAAAGYQHI-RMYDLNSNNPNPIISYDGV 84 W A +R + V + + P D +++DL + + G Sbjct: 125 WHAP-WKLSRVINGHLGWVRCVAIDPVDNEWFITGSNDTTMKVWDLATGKLKT--TLAGH 181 Query: 85 NKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELI 144 + V + ++++ ED T + WDL + + + + + V +HP + Sbjct: 182 VMTVRDVAVSDRHPYLFSVSEDKTVKCWDLEKNQI-IRDYYGHLSGVRTVSIHPTLDLIA 240 Query: 145 VGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIG 204 + I +WD++T + + I P + + ++ +W++ G Sbjct: 241 TAGRDSVIKLWDMRTRIPVITLVGHKGPINQVQCTPVDPQVVSSSTDATVRLWDVVAGKT 300 Query: 205 DEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGN 264 +V + H R P +A+ D + W + SL+T + Sbjct: 301 MKV--------LTHHKRSVRATALHPKEFSVASACTDD-IRSWGLAEGSLLTNFESEK-- 349 Query: 265 PGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETG---------EIKREYGGHQKAV 315 G + + + D + + + + ++G E+ G +++V Sbjct: 350 -----TGIINTLSINQD-DVLFAGGDNGVLSFYDYKSGHKYQSLATREMVGSLEG-ERSV 402 Query: 316 VCLAFNDS 323 +C F+ + Sbjct: 403 LCSTFDKT 410 >2YNP-A nrPDB Length = 604 Score = 180 bits (456), Expect = 8e-46, Method: Composition-based stats. Identities = 53/292 (18%), Positives = 103/292 (35%), Gaps = 20/292 (6%) Query: 9 GSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMY 68 ++P +L T Y V W + + R++Q ++ V A + ++ I R+ Sbjct: 23 PTEPWVLTTL-YSGRVELWNYETQVEVRSIQVTETPVRAGKFIARKNWIIVGSDD-FRIR 80 Query: 69 DLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVN 128 N N ++ ++ I S+ H ++ +G +D T ++W+ + Q Sbjct: 81 VFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWNWENNWALEQTFEGHE 140 Query: 129 APINCVCLHP-NQAELIVGDQSGAIHIWDL-KTDHNEQLIPEPEVSITSAHI--DPDASY 184 + CV +P + + G + +W L ++ N L E + PD Y Sbjct: 141 HFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQERGVNYVDYYPLPDKPY 200 Query: 185 MAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTC 244 M + +W+ + H F P ++ + S D T Sbjct: 201 MITASDDLTIKIWDYQTKS--------CVATLEGHMSNVSFAVFHPTLPIIISGSEDGTL 252 Query: 245 KIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARL 296 KIW +S + + L++ R W +G YI + + L Sbjct: 253 KIWNSSTYKVEKTLNVGL------ERSWCIATHPTGRKNYIASGFDNGFTVL 298 Score = 154 bits (390), Expect = 3e-38, Method: Composition-based stats. Identities = 42/247 (17%), Positives = 86/247 (34%), Gaps = 14/247 (5%) Query: 79 ISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHP 138 ++ + + + FH W+ T +W+ ++ ++ + I P+ Sbjct: 7 KTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVELWNYETQ-VEVRSIQVTETPVRAGKFIA 65 Query: 139 NQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWN 198 + +IVG I +++ T I S + P Y+ + + +WN Sbjct: 66 RKNWIIVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWN 125 Query: 199 LTGGIGDEVTQLIPKTKIPAHTRYALQCRFSP-DSTLLATCSADQTCKIWRTSNFSLMTE 257 E T H + + F+P D + A+ D+T K+W Sbjct: 126 WENNWALEQT-------FEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSL--GQSTPN 176 Query: 258 LSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVC 317 ++ +G + + D Y++TAS D ++W +T GH V Sbjct: 177 FTLTTGQERGVNYVDYYPL---PDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSF 233 Query: 318 LAFNDSV 324 F+ ++ Sbjct: 234 AVFHPTL 240 Score = 133 bits (334), Expect = 1e-31, Method: Composition-based stats. Identities = 46/294 (15%), Positives = 99/294 (33%), Gaps = 23/294 (7%) Query: 35 TRTVQHQDSQVNALEVTPDRSMIAAA-GYQHIRMYDLNSNNPNPIISYDGVNKNIASVGF 93 +T ++ +V ++ P + + +++ + + S + + F Sbjct: 6 KKTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVELWNYETQ--VEVRSIQVTETPVRAGKF 63 Query: 94 HEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIH 153 W+ G +D R+++ + + I + +HP + ++ G + Sbjct: 64 IARKNWIIVGSDDFRIRVFNYNTGEKVVDFEAHPDY-IRSIAVHPTKPYVLSGSDDLTVK 122 Query: 154 IWDLKTD-HNEQLIPEPEVSITSAHIDP-DASYMAAVNSTGNCYVWNLTGGIGDEVTQLI 211 +W+ + + EQ E + +P D S A+ VW+L + Sbjct: 123 LWNWENNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNF----- 177 Query: 212 PKTKIPAHTRYALQCRF--SPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESS 269 T R + PD + T S D T KIW S + L E Sbjct: 178 --TLTTGQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATL--------EGH 227 Query: 270 RGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDS 323 + F I++ S D ++W T ++++ + C+A + + Sbjct: 228 MSNVSFAVFHPTLPIIISGSEDGTLKIWNSSTYKVEKTLNVGLERSWCIATHPT 281 Score = 62.1 bits (149), Expect = 4e-10, Method: Composition-based stats. Identities = 22/150 (14%), Positives = 44/150 (29%), Gaps = 35/150 (23%) Query: 208 TQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNF--------------- 252 +L K + F P + T ++W Sbjct: 1 MKLDIKKTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVELWNYETQVEVRSIQVTETPVRA 60 Query: 253 ----------------SLMTELSIKSGNPG---ESSRGWMWGCAFSGDSQYIVTASSDNL 293 + + +G E+ ++ A Y+++ S D Sbjct: 61 GKFIARKNWIIVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLT 120 Query: 294 ARLWCVETG-EIKREYGGHQKAVVCLAFND 322 +LW E +++ + GH+ V+C+AFN Sbjct: 121 VKLWNWENNWALEQTFEGHEHFVMCVAFNP 150 Score = 55.2 bits (131), Expect = 4e-08, Method: Composition-based stats. Identities = 46/291 (15%), Positives = 90/291 (30%), Gaps = 23/291 (7%) Query: 2 NTSPGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDR--SMIAA 59 N S I+ + D T++ W + + +T+ + + P + IA+ Sbjct: 230 NVSFAVFHPTLPIIISGSEDGTLKIWNSSTYKVEKTLNVGLERSWCIATHPTGRKNYIAS 289 Query: 60 AGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNL 119 + L N P +S D V K + S G + ++T + +L Sbjct: 290 GFDNGFTVLSL--GNDEPTLSLDPVGKLVWSGGKNAAASDIFTAVIRGNEEVEQDEPLSL 347 Query: 120 QCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHID 179 Q + + V+ + PN + V G I+ N+ Sbjct: 348 QTKELGSVDVFPQSLAHSPNGRFVTVVG-DGEYVIYTALAWRNKAF-----GKCQDFVWG 401 Query: 180 PDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCS 239 PD++ A ++ TG T A+ FS LL S Sbjct: 402 PDSNSYALIDETGQIK----------YYKNFKEVTSWSVPMHSAIDRLFS--GALLGVKS 449 Query: 240 ADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASS 290 D + N +L+ + + + + S G + + + + + Sbjct: 450 -DGFVYFFDWDNGTLVRRIDVNAKDVIWSDNGELVMIVNTNSNGDEASGYT 499 >4BTS-AR nrPDB Length = 343 Score = 175 bits (443), Expect = 3e-44, Method: Composition-based stats. Identities = 49/317 (15%), Positives = 108/317 (34%), Gaps = 36/317 (11%) Query: 9 GSDPVILATAGYDHTVRFWQAHS-------GICTRTVQHQDSQVNALEVTPDRSMIAAAG 61 D +L + D TV W+ + GI + + + V+ L ++ + ++ Sbjct: 36 NEDSPVLISGSRDKTVMIWKLYEEEQNGYFGIPHKALTGHNHFVSDLALSQENCFAISSS 95 Query: 62 YQ-HIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQ 120 + +R++DL + + G + SV F D R + + G + ++W++ Sbjct: 96 WDKTLRLWDLRTGTTYK--RFVGHQSEVYSVAFSPDNRQILSAGAEREIKLWNILGECKF 153 Query: 121 CQRIFQVNA-PINCVCLHPN----------QAELIVGDQSGAIHIWDLKTDHNEQLIPEP 169 + ++ ++CV P G + +W+ Sbjct: 154 SSAEKENHSDWVSCVRYSPIMKSANKVQPFAPYFASVGWDGRLKVWNT-NFQIRYTFKAH 212 Query: 170 EVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFS 229 E ++ I P+ Y+A +W++ P+ + A Q F+ Sbjct: 213 ESNVNHLSISPNGKYIATGGKDKKLLIWDILNLT-------YPQREFDA-GSTINQIAFN 264 Query: 230 PDSTLLATCSADQTCKIWRTSNFSLMTELSIKS-----GNPGESSRGWMWGCAFSGDSQY 284 P +A + DQ KI+ S +I++ + A++ + Sbjct: 265 PKLQWVAVGT-DQGVKIFNLMTQSKAPVCTIEAEPITKAEGQKGKNPQCTSLAWNALGKK 323 Query: 285 IVTASSDNLARLWCVET 301 + +D + R + ET Sbjct: 324 LFAGFTDGVIRTFSFET 340 Score = 144 bits (364), Expect = 4e-35, Method: Composition-based stats. Identities = 44/288 (15%), Positives = 96/288 (33%), Gaps = 43/288 (14%) Query: 38 VQHQDSQVNALEV------TPDRSMIAAAG-YQHIRMYDLNSNNPN-----PIISYDGVN 85 ++ V ++ D ++ + + + ++ L N P + G N Sbjct: 17 LEGHSDWVTSIVAGFSQKENEDSPVLISGSRDKTVMIWKLYEEEQNGYFGIPHKALTGHN 76 Query: 86 KNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIV 145 ++ + ++ + + D T R+WDLR+ +R + + V P+ +++ Sbjct: 77 HFVSDLALSQENCFAISSSWDKTLRLWDLRTGTTY-KRFVGHQSEVYSVAFSPDNRQILS 135 Query: 146 GDQSGAIHIWDLKTDHNEQLIPE--PEVSITSAHID----------PDASYMAAVNSTGN 193 I +W++ + + ++ P A Y A+V G Sbjct: 136 AGAEREIKLWNILGECKFSSAEKENHSDWVSCVRYSPIMKSANKVQPFAPYFASVGWDGR 195 Query: 194 CYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFS 253 VWN T + AH SP+ +AT D+ IW Sbjct: 196 LKVWN---------TNFQIRYTFKAHESNVNHLSISPNGKYIATGGKDKKLLIWDI---- 242 Query: 254 LMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVET 301 L++ + + AF+ Q++ +D +++ + T Sbjct: 243 ----LNLTYPQREFDAGSTINQIAFNPKLQWVAVG-TDQGVKIFNLMT 285 Score = 143 bits (361), Expect = 9e-35, Method: Composition-based stats. Identities = 45/266 (16%), Positives = 85/266 (31%), Gaps = 37/266 (13%) Query: 81 YDGVNKNIASV--GFHE----DGRWMYTGGEDCTARIWDL------RSRNLQCQRIFQVN 128 +G + + S+ GF + D + +G D T IW L + + + N Sbjct: 17 LEGHSDWVTSIVAGFSQKENEDSPVLISGSRDKTVMIWKLYEEEQNGYFGIPHKALTGHN 76 Query: 129 APINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAV 188 ++ + L I + +WDL+T + + + S PD + + Sbjct: 77 HFVSDLALSQENCFAISSSWDKTLRLWDLRTGTTYKRFVGHQSEVYSVAFSPDNRQILSA 136 Query: 189 NSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDST----------LLATC 238 + +WN+ G + H+ + R+SP A+ Sbjct: 137 GAEREIKLWNILGECK------FSSAEKENHSDWVSCVRYSPIMKSANKVQPFAPYFASV 190 Query: 239 SADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWC 298 D K+W T NF + N + S + +YI T D +W Sbjct: 191 GWDGRLKVWNT-NFQIRYTFKAHESNVNH--------LSISPNGKYIATGGKDKKLLIWD 241 Query: 299 VETGEIKREYGGHQKAVVCLAFNDSV 324 + + + +AFN + Sbjct: 242 ILNLTYPQREFDAGSTINQIAFNPKL 267 Score = 57.1 bits (136), Expect = 1e-08, Method: Composition-based stats. Identities = 19/122 (15%), Positives = 47/122 (38%), Gaps = 11/122 (9%) Query: 7 TVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIR 66 ++ + +AT G D + W + + S +N + P +A Q ++ Sbjct: 220 SISPNGKYIATGGKDKKLLIWDILNLTYPQREFDAGSTINQIAFNPKLQWVAVGTDQGVK 279 Query: 67 MYDLNSNNPNPIISYD-----------GVNKNIASVGFHEDGRWMYTGGEDCTARIWDLR 115 +++L + + P+ + + G N S+ ++ G+ ++ G D R + Sbjct: 280 IFNLMTQSKAPVCTIEAEPITKAEGQKGKNPQCTSLAWNALGKKLFAGFTDGVIRTFSFE 339 Query: 116 SR 117 + Sbjct: 340 TS 341 >3JB9-L nrPDB Length = 340 Score = 173 bits (439), Expect = 8e-44, Method: Composition-based stats. Identities = 55/285 (19%), Positives = 110/285 (38%), Gaps = 16/285 (5%) Query: 15 LATAGYDHTVRFWQAHSGICTR-TVQHQDSQVNALEVTPDRSMI-AAAGYQHIRMYDLNS 72 A+ G D + W + + + L+ + D ++ ++ H+ +D S Sbjct: 65 FASGGMDRQILLWNVFGDVKNYGVLNGCKGAITDLQWSRDSRVVYCSSSDTHLMSWDAVS 124 Query: 73 NNPNPIISYDGVNKNIASVGFHEDGRWMYTG-GEDCTARIWDLRSRNLQCQRIFQVNAPI 131 I + G + ++ + G + T +DCT ++WD RS++ C + + P+ Sbjct: 125 GQ--KIRKHKGHAGVVNALDVLKVGSELLTSVSDDCTMKVWDSRSKD--CIKTIEEKYPL 180 Query: 132 NCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNST 191 V + ++ +G GAI IWDL+ +H ++ + ITS I D S + + + Sbjct: 181 TAVAIAQQGTQVFIGGIDGAIKIWDLRNNHCSHVLKGHKDIITSLAISKDGSSLLSNSMD 240 Query: 192 GNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSN 251 ++++ + I + I L +S +S + S+D+ +W + Sbjct: 241 NTVRIFDVKPFASAQRQLQIFEGAIHGQEHNLLGVAWSRNSRFVGAGSSDKNVYVWS-AT 299 Query: 252 FSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARL 296 L L G+ F I++ SSD L Sbjct: 300 GDLRYVLPGHEGSVNH--------VDFHPHQDIILSCSSDRTIFL 336 Score = 146 bits (367), Expect = 2e-35, Method: Composition-based stats. Identities = 51/245 (20%), Positives = 98/245 (40%), Gaps = 21/245 (8%) Query: 9 GSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMY 68 D ++ + D + W A SG R + VNAL+V S + + M Sbjct: 102 SRDSRVVYCSSSDTHLMSWDAVSGQKIRKHKGHAGVVNALDVLKVGSELLTSVSDDCTMK 161 Query: 69 DLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVN 128 +S + + I + + + +V + G ++ GG D +IWDLR+ C + + + Sbjct: 162 VWDSRSKDCIKTIE-EKYPLTAVAIAQQGTQVFIGGIDGAIKIWDLRNN--HCSHVLKGH 218 Query: 129 AP-INCVCLHPNQAELIVGDQSGAIHIWDLKTDH--------NEQLIPEPEVSITSAHID 179 I + + + + L+ + I+D+K E I E ++ Sbjct: 219 KDIITSLAISKDGSSLLSNSMDNTVRIFDVKPFASAQRQLQIFEGAIHGQEHNLLGVAWS 278 Query: 180 PDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCS 239 ++ ++ A +S N YVW+ TG + + +P H F P ++ +CS Sbjct: 279 RNSRFVGAGSSDKNVYVWSATGDL---------RYVLPGHEGSVNHVDFHPHQDIILSCS 329 Query: 240 ADQTC 244 +D+T Sbjct: 330 SDRTI 334 Score = 145 bits (365), Expect = 3e-35, Method: Composition-based stats. Identities = 51/285 (17%), Positives = 104/285 (36%), Gaps = 14/285 (4%) Query: 40 HQDSQVNALEVTPDRSMIAAAG-YQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGR 98 ++V P S A+ G + I ++++ + +G I + + D R Sbjct: 48 GHTAEVLVARFDPSGSYFASGGMDRQILLWNV-FGDVKNYGVLNGCKGAITDLQWSRDSR 106 Query: 99 WMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVG-DQSGAIHIWDL 157 +Y D WD S + ++ +N + + +EL+ + +WD Sbjct: 107 VVYCSSSDTHLMSWDAVSGQ-KIRKHKGHAGVVNALDVLKVGSELLTSVSDDCTMKVWDS 165 Query: 158 KTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIP 217 ++ + I E + +T+ I + + G +W+L V + Sbjct: 166 RSKDCIKTI-EEKYPLTAVAIAQQGTQVFIGGIDGAIKIWDLRNNHCSHV--------LK 216 Query: 218 AHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCA 277 H S D + L + S D T +I+ F+ + G A Sbjct: 217 GHKDIITSLAISKDGSSLLSNSMDNTVRIFDVKPFASAQRQLQIFEGAIHGQEHNLLGVA 276 Query: 278 FSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFND 322 +S +S+++ SSD +W TG+++ GH+ +V + F+ Sbjct: 277 WSRNSRFVGAGSSDKNVYVWSA-TGDLRYVLPGHEGSVNHVDFHP 320 Score = 100 bits (250), Expect = 6e-22, Method: Composition-based stats. Identities = 32/212 (15%), Positives = 66/212 (31%), Gaps = 21/212 (9%) Query: 115 RSRNLQCQRI--FQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTD-HNEQLIPEPEV 171 R+ +L + F A + P+ + G I +W++ D N ++ + Sbjct: 35 RTSDLNVPNLQMFGHTAEVLVARFDPSGSYFASGGMDRQILLWNVFGDVKNYGVLNGCKG 94 Query: 172 SITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPD 231 +IT D+ + +S + W+ G K H Sbjct: 95 AITDLQWSRDSRVVYCSSSDTHLMSWDAVSG--------QKIRKHKGHAGVVNALDVLKV 146 Query: 232 STLLATC-SADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASS 290 + L T S D T K+W + + + + + + A + + Sbjct: 147 GSELLTSVSDDCTMKVWDSRSKDCIKTIE---------EKYPLTAVAIAQQGTQVFIGGI 197 Query: 291 DNLARLWCVETGEIKREYGGHQKAVVCLAFND 322 D ++W + GH+ + LA + Sbjct: 198 DGAIKIWDLRNNHCSHVLKGHKDIITSLAISK 229 Score = 91.4 bits (225), Expect = 5e-19, Method: Composition-based stats. Identities = 21/152 (13%), Positives = 55/152 (36%), Gaps = 9/152 (5%) Query: 8 VGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQ-HIR 66 + + G D ++ W + C+ ++ + +L ++ D S + + +R Sbjct: 185 IAQQGTQVFIGGIDGAIKIWDLRNNHCSHVLKGHKDIITSLAISKDGSSLLSNSMDNTVR 244 Query: 67 MYDLN--SNNPNPIISYDGVNKN----IASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQ 120 ++D+ ++ + ++G + V + + R++ G D +W Sbjct: 245 IFDVKPFASAQRQLQIFEGAIHGQEHNLLGVAWSRNSRFVGAGSSDKNVYVWSATGDLRY 304 Query: 121 CQRIFQVNAPINCVCLHPNQAELIVGDQSGAI 152 + +N V HP+Q ++ I Sbjct: 305 V--LPGHEGSVNHVDFHPHQDIILSCSSDRTI 334 >5NZU-C nrPDB Length = 905 Score = 170 bits (431), Expect = 6e-43, Method: Composition-based stats. Identities = 44/293 (15%), Positives = 104/293 (35%), Gaps = 25/293 (8%) Query: 9 GSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQ-HIRM 67 ++P +LA+ Y+ +V W + +T + D V A + ++ + IR+ Sbjct: 25 PTEPWMLASL-YNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVARKNWVVTGADDMQIRV 83 Query: 68 YDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQV 127 ++ N+ + ++ + I + H ++ T +D ++WD + C ++F+ Sbjct: 84 FNYNTLERVHM--FEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWD-KKWSCSQVFEG 140 Query: 128 NAP-INCVCLHP-NQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDP--DAS 183 + + + ++P + + I +W L + + E + D Sbjct: 141 HTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYSGGDKP 200 Query: 184 YMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQT 243 Y+ + +W+ + H + F P+ ++ T S D T Sbjct: 201 YLISGADDRLVKIWDYQNKT--------CVQTLEGHAQNVSCASFHPELPIIITGSEDGT 252 Query: 244 CKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARL 296 +IW +S + L + L+ +W A S + + + Sbjct: 253 VRIWHSSTYRLESTLNYGM--------ERVWCVASLRGSNNVALGYDEGSIIV 297 Score = 167 bits (422), Expect = 7e-42, Method: Composition-based stats. Identities = 40/247 (16%), Positives = 89/247 (36%), Gaps = 15/247 (6%) Query: 79 ISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHP 138 + + SV H WM + + +W+ ++ L + + P+ Sbjct: 9 RKLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTL-VKTFEVCDLPVRAAKFVA 67 Query: 139 NQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWN 198 + ++ G I +++ T + I + P ++ + +W+ Sbjct: 68 RKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWD 127 Query: 199 LTGGIGDEVTQLIPKTKIPAHTRYALQCRFSP-DSTLLATCSADQTCKIWRTSNFSLMTE 257 HT Y +Q +P D+ A+ S D+T K+W+ + S Sbjct: 128 WDKKWS-------CSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSS--PN 178 Query: 258 LSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVC 317 +++ G + + G GD Y+++ + D L ++W + + GH + V C Sbjct: 179 FTLEGHEKGVNCIDYYSG----GDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSC 234 Query: 318 LAFNDSV 324 +F+ + Sbjct: 235 ASFHPEL 241 Score = 147 bits (370), Expect = 7e-36, Method: Composition-based stats. Identities = 48/290 (16%), Positives = 105/290 (36%), Gaps = 24/290 (8%) Query: 35 TRTVQHQDSQVNALEVTPDRSMIAAAGYQ-HIRMYDLNSNNPNPIISYDGVNKNIASVGF 93 R + + +V ++++ P + A+ Y + +++ + + +++ + + + F Sbjct: 8 KRKLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQT--LVKTFEVCDLPVRAAKF 65 Query: 94 HEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIH 153 W+ TG +D R+++ + + I C+ +HP Q ++ I Sbjct: 66 VARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDY-IRCIAVHPTQPFILTSSDDMLIK 124 Query: 154 IWDLKTD-HNEQLIPEPEVSITSAHIDP-DASYMAAVNSTGNCYVWNLTGGIGDEVTQLI 211 +WD Q+ + I+P D + A+ + VW L Sbjct: 125 LWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSS-------- 176 Query: 212 PKTKIPAHTRYALQCRFSPDST--LLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESS 269 P + H + + L + + D+ KIW N + + L + N Sbjct: 177 PNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQN----- 231 Query: 270 RGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLA 319 + +F + I+T S D R+W T ++ + V C+A Sbjct: 232 ---VSCASFHPELPIIITGSEDGTVRIWHSSTYRLESTLNYGMERVWCVA 278 Score = 71.3 bits (173), Expect = 5e-13, Method: Composition-based stats. Identities = 15/105 (14%), Positives = 38/105 (36%), Gaps = 3/105 (2%) Query: 8 VGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQ-HIR 66 G D L + D V+ W + C +T++ V+ P+ +I +R Sbjct: 195 SGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIIITGSEDGTVR 254 Query: 67 MYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARI 111 ++ ++ ++Y + + V + G ++ + + Sbjct: 255 IWHSSTYRLESTLNYG--MERVWCVASLRGSNNVALGYDEGSIIV 297 Score = 67.1 bits (162), Expect = 9e-12, Method: Composition-based stats. Identities = 18/114 (15%), Positives = 37/114 (32%), Gaps = 8/114 (7%) Query: 210 LIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESS 269 L K K+ A + P + + + +W +L+ E Sbjct: 5 LDIKRKLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTF--------EVC 56 Query: 270 RGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDS 323 + F ++VT + D R++ T E + H + C+A + + Sbjct: 57 DLPVRAAKFVARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPT 110 Score = 43.2 bits (100), Expect = 1e-04, Method: Composition-based stats. Identities = 38/276 (13%), Positives = 75/276 (27%), Gaps = 26/276 (9%) Query: 2 NTSPGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAG 61 N S + + I+ T D TVR W + + T+ + +V + + +A Sbjct: 231 NVSCASFHPELPIIITGSEDGTVRIWHSSTYRLESTLNYGMERVWCVASLRGSNNVALGY 290 Query: 62 YQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQC 121 + + + P +S D K I + E + D + D L Sbjct: 291 DEGSII--VKLGREEPAMSMDANGKIIWA-KHSEVQQANLKAMGDTEIK--DGERLPLAV 345 Query: 122 QRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPD 181 + + + +PN ++V G I+ N+ S D Sbjct: 346 KDMGSCEIYPQTIQHNPNGRFVVVCG-DGEYIIYTAMALRNKSF-----GSAQEFAWAHD 399 Query: 182 ASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSAD 241 +S A S ++ ++ Sbjct: 400 SSEYAIRESNSIVKIFKNFKEKKSFKPDFGAESIYGGFLLGVRSV--------------- 444 Query: 242 QTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCA 277 + N L+ + I+ + S G + A Sbjct: 445 NGLAFYDWENTELIRRIEIQPKHIFWSDSGELVCIA 480 >6QDV-o nrPDB Length = 513 Score = 169 bits (427), Expect = 2e-42, Method: Composition-based stats. Identities = 44/298 (14%), Positives = 99/298 (33%), Gaps = 18/298 (6%) Query: 33 ICTRTVQHQDSQVNALEVTP-DRSMIAAAGYQ-HIRMYDLNSNNPNPIISYDGVNKNIAS 90 V+A+ + P ++ + I+++++ + ++ G +K + Sbjct: 213 KQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEV-YGERRCLRTFIGHSKAVRD 271 Query: 91 VGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQ---AELIVGD 147 + F+ G + D ++WD + QC F CV +P++ + G Sbjct: 272 ICFNTAGTQFLSAAYDRYLKLWDTETG--QCISRFTNRKVPYCVKFNPDEDKQNLFVAGM 329 Query: 148 QSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEV 207 I WD+++ Q ++ + + + + + VW Sbjct: 330 SDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDI------ 383 Query: 208 TQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGE 267 + K SP+ LA S D I+ N + + I G+ Sbjct: 384 -PVDFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMV- 441 Query: 268 SSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDSVL 325 G+ FS D Y+++ + +W +T ++ + H K + ++ Sbjct: 442 --AGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHET 497 Score = 154 bits (389), Expect = 4e-38, Method: Composition-based stats. Identities = 47/294 (15%), Positives = 100/294 (34%), Gaps = 26/294 (8%) Query: 14 ILATAGYDHTVRFWQAH-SGICTRTVQHQDSQVNALEVTPDRSMIAAAG-YQHIRMYDLN 71 +L + D ++ W+ + C RT V + + +A ++++++D Sbjct: 237 LLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTE 296 Query: 72 SNNPNPIISYDGVNKNIASVGFHED---GRWMYTGGEDCTARIWDLRSRNLQCQRIFQVN 128 + + K V F+ D G D WD+RS + Q + Sbjct: 297 TGQCISRFT---NRKVPYCVKFNPDEDKQNLFVAGMSDKKIVQWDIRSGEI-VQEYDRHL 352 Query: 129 APINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEV-SITSAHIDPDASYMAA 187 +N + + ++ +W+ + + I EP + S+ + + P+ ++A Sbjct: 353 GAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHSMPAVTLSPNGKWLAC 412 Query: 188 VNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHT--RYALQCRFSPDSTLLATCSADQTCK 245 + ++ +L K H YA Q FSPD + + + + Sbjct: 413 QSMDNQILIFG-----AQNRFRLNKKKIFKGHMVAGYACQVDFSPDMSYVISGDGNGKLN 467 Query: 246 IWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSG-DSQYIVTASSDNLARLWC 298 IW L + + G + ++ ++T D L +LW Sbjct: 468 IWDWKTTKLYSRFK--------AHDKVCIGAVWHPHETSKVITCGWDGLIKLWD 513 Score = 99.8 bits (247), Expect = 2e-21, Method: Composition-based stats. Identities = 33/195 (16%), Positives = 70/195 (35%), Gaps = 7/195 (3%) Query: 10 SDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQH-IRMY 68 + D + W SG + VN + + + +R++ Sbjct: 320 DKQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVW 379 Query: 69 DLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSR-NLQCQRIFQV 127 + + I+ + ++ +V +G+W+ D I+ ++R L ++IF+ Sbjct: 380 EWDIPVDFKYIA-EPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKG 438 Query: 128 NAPIN---CVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDP-DAS 183 + V P+ + +I GD +G ++IWD KT + A P + S Sbjct: 439 HMVAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETS 498 Query: 184 YMAAVNSTGNCYVWN 198 + G +W+ Sbjct: 499 KVITCGWDGLIKLWD 513 Score = 40.9 bits (94), Expect = 8e-04, Method: Composition-based stats. Identities = 8/63 (12%), Positives = 20/63 (31%), Gaps = 2/63 (3%) Query: 9 GSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTP-DRSMIAAAGYQH-IR 66 D + + + + W + + D P + S + G+ I+ Sbjct: 451 SPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETSKVITCGWDGLIK 510 Query: 67 MYD 69 ++D Sbjct: 511 LWD 513 >5YZG-W nrPDB Length = 579 Score = 169 bits (427), Expect = 2e-42, Method: Composition-based stats. Identities = 44/298 (14%), Positives = 99/298 (33%), Gaps = 18/298 (6%) Query: 33 ICTRTVQHQDSQVNALEVTP-DRSMIAAAGYQ-HIRMYDLNSNNPNPIISYDGVNKNIAS 90 V+A+ + P ++ + I+++++ + ++ G +K + Sbjct: 279 KQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEV-YGERRCLRTFIGHSKAVRD 337 Query: 91 VGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQ---AELIVGD 147 + F+ G + D ++WD + QC F CV +P++ + G Sbjct: 338 ICFNTAGTQFLSAAYDRYLKLWDTETG--QCISRFTNRKVPYCVKFNPDEDKQNLFVAGM 395 Query: 148 QSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEV 207 I WD+++ Q ++ + + + + + VW Sbjct: 396 SDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDI------ 449 Query: 208 TQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGE 267 + K SP+ LA S D I+ N + + I G+ Sbjct: 450 -PVDFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMV- 507 Query: 268 SSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDSVL 325 G+ FS D Y+++ + +W +T ++ + H K + ++ Sbjct: 508 --AGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHET 563 Score = 154 bits (389), Expect = 4e-38, Method: Composition-based stats. Identities = 47/294 (15%), Positives = 100/294 (34%), Gaps = 26/294 (8%) Query: 14 ILATAGYDHTVRFWQAH-SGICTRTVQHQDSQVNALEVTPDRSMIAAAG-YQHIRMYDLN 71 +L + D ++ W+ + C RT V + + +A ++++++D Sbjct: 303 LLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTE 362 Query: 72 SNNPNPIISYDGVNKNIASVGFHED---GRWMYTGGEDCTARIWDLRSRNLQCQRIFQVN 128 + + K V F+ D G D WD+RS + Q + Sbjct: 363 TGQCISRFT---NRKVPYCVKFNPDEDKQNLFVAGMSDKKIVQWDIRSGEI-VQEYDRHL 418 Query: 129 APINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEV-SITSAHIDPDASYMAA 187 +N + + ++ +W+ + + I EP + S+ + + P+ ++A Sbjct: 419 GAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHSMPAVTLSPNGKWLAC 478 Query: 188 VNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHT--RYALQCRFSPDSTLLATCSADQTCK 245 + ++ +L K H YA Q FSPD + + + + Sbjct: 479 QSMDNQILIFG-----AQNRFRLNKKKIFKGHMVAGYACQVDFSPDMSYVISGDGNGKLN 533 Query: 246 IWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSG-DSQYIVTASSDNLARLWC 298 IW L + + G + ++ ++T D L +LW Sbjct: 534 IWDWKTTKLYSRFK--------AHDKVCIGAVWHPHETSKVITCGWDGLIKLWD 579 Score = 99.8 bits (247), Expect = 2e-21, Method: Composition-based stats. Identities = 33/195 (16%), Positives = 70/195 (35%), Gaps = 7/195 (3%) Query: 10 SDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQH-IRMY 68 + D + W SG + VN + + + +R++ Sbjct: 386 DKQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVW 445 Query: 69 DLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSR-NLQCQRIFQV 127 + + I+ + ++ +V +G+W+ D I+ ++R L ++IF+ Sbjct: 446 EWDIPVDFKYIA-EPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKG 504 Query: 128 NAPIN---CVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDP-DAS 183 + V P+ + +I GD +G ++IWD KT + A P + S Sbjct: 505 HMVAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETS 564 Query: 184 YMAAVNSTGNCYVWN 198 + G +W+ Sbjct: 565 KVITCGWDGLIKLWD 579 Score = 40.9 bits (94), Expect = 9e-04, Method: Composition-based stats. Identities = 8/63 (12%), Positives = 20/63 (31%), Gaps = 2/63 (3%) Query: 9 GSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTP-DRSMIAAAGYQH-IR 66 D + + + + W + + D P + S + G+ I+ Sbjct: 517 SPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETSKVITCGWDGLIK 576 Query: 67 MYD 69 ++D Sbjct: 577 LWD 579 >5GAN-H nrPDB Length = 465 Score = 168 bits (426), Expect = 3e-42, Method: Composition-based stats. Identities = 49/299 (16%), Positives = 114/299 (38%), Gaps = 22/299 (7%) Query: 7 TVGSDPVILATAGYDHTVRFWQAHSGICT-RTVQHQDSQVNALEVTPDRS--MIAAAGYQ 63 ++ +D +++AT + ++ + + + + ++ A++ PD + MI+ A Sbjct: 182 SLSTDDMVVATGSWAGDLQVLNSQTLQPLTQKLDSHVGKIGAIDWHPDSNNQMISCAEDG 241 Query: 64 HIR--MYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQC 121 I+ Y + G + I+ V +H G+++ + D T R+WD S + + Sbjct: 242 LIKNFQYSNEEGGLRLLGDLVGHERRISDVKYHPSGKFIGSASHDMTWRLWD-ASTHQEL 300 Query: 122 QRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPD 181 + + + + + + G +WD+++ + I + P+ Sbjct: 301 LLQEGHDKGVFSLSFQCDGSLVCSGGMDSLSMLWDIRSGSKVMTLAGHSKPIYTVAWSPN 360 Query: 182 ASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPD--STLLATCS 239 +A G VW++ ++ Q++ AH Q RFS + L +C Sbjct: 361 GYQVATGGGDGIINVWDIRKRDEGQLNQIL------AHRNIVTQVRFSKEDGGKKLVSCG 414 Query: 240 ADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWC 298 D ++ + + M L+ + + S +S ++V+ D +LW Sbjct: 415 YDNLINVYSSDTWLKMGSLAGHT--------DKIISLDISNNSHFLVSGGWDRSIKLWN 465 Score = 149 bits (375), Expect = 2e-36, Method: Composition-based stats. Identities = 43/290 (14%), Positives = 96/290 (33%), Gaps = 22/290 (7%) Query: 41 QDSQVNALEVTPDRSMIAAAGY-QHIRMYDLNSNNPNPIISYDGVNKNIASVGFHED-GR 98 ++A+ ++ D ++A + +++ + + P D I ++ +H D Sbjct: 174 STKPISAVSLSTDDMVVATGSWAGDLQVLNSQTLQPL-TQKLDSHVGKIGAIDWHPDSNN 232 Query: 99 WMYTGGEDCTARIW---DLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIW 155 M + ED + + + + I+ V HP+ + +W Sbjct: 233 QMISCAEDGLIKNFQYSNEEGGLRLLGDLVGHERRISDVKYHPSGKFIGSASHDMTWRLW 292 Query: 156 DLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTK 215 D T L + + S D S + + +W++ G Sbjct: 293 DASTHQELLLQEGHDKGVFSLSFQCDGSLVCSGGMDSLSMLWDIRSGSKVM--------T 344 Query: 216 IPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWG 275 + H++ +SP+ +AT D +W N + R + Sbjct: 345 LAGHSKPIYTVAWSPNGYQVATGGGDGIINVWDIRKRDEGQ------LNQILAHRNIVTQ 398 Query: 276 CAFSGD--SQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDS 323 FS + + +V+ DNL ++ +T GH ++ L +++ Sbjct: 399 VRFSKEDGGKKLVSCGYDNLINVYSSDTWLKMGSLAGHTDKIISLDISNN 448 >5WYJ-BC nrPDB Length = 817 Score = 166 bits (419), Expect = 1e-41, Method: Composition-based stats. Identities = 66/319 (20%), Positives = 115/319 (36%), Gaps = 44/319 (13%) Query: 28 QAHSGICTRTVQHQDSQVNALEVT-PDRSMIAAA----GYQHIRMYDL---NSNNPNPII 79 + T ++ + + P+ + +A A + I + DL ++ P + Sbjct: 323 DEDTIQVTSSIAGNHGIIADMRYVGPELNKLALATNSPSLRIIPVPDLSGPEASLPLDVE 382 Query: 80 SYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQ---RIFQVNAPINCVCL 136 Y+G + S+ EDG W+ T +D TA +W + + + +A + V L Sbjct: 383 IYEGHEDLLNSLDATEDGLWIATASKDNTAIVWRYNENSCKFDIYAKYIGHSAAVTAVGL 442 Query: 137 HPN------QAELIVGDQSGAIHIWDLKTDHNEQLIP----------EPEVSITSAHIDP 180 PN L+ I W + + E I + + P Sbjct: 443 -PNIVSKGYPEFLLTASNDLTIKKWIIPKPTASMDVQIIKVSEYTRHAHEKDINALSVSP 501 Query: 181 DASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSA 240 + S A + C +WNL G + + H R F LLAT S Sbjct: 502 NDSIFATASYDKTCKIWNLENG--------ELEATLANHKRGLWDVSFCQYDKLLATSSG 553 Query: 241 DQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVE 300 D+T KIW FS+M L E + C+F + +++ +D L ++W Sbjct: 554 DKTVKIWSLDTFSVMKTL--------EGHTNAVQRCSFINKQKQLISCGADGLIKIWDCS 605 Query: 301 TGEIKREYGGHQKAVVCLA 319 +GE + GH + L+ Sbjct: 606 SGECLKTLDGHNNRLWALS 624 Score = 147 bits (370), Expect = 7e-36, Method: Composition-based stats. Identities = 49/276 (17%), Positives = 92/276 (33%), Gaps = 33/276 (11%) Query: 39 QHQDSQVNALEVTPDRSMIAAAGYQHIRM-YDLNSNNP--NPIISYDGVNKNIASVGFHE 95 + + +N+L+ T D IA A + + + N N+ + Y G + + +VG Sbjct: 385 EGHEDLLNSLDATEDGLWIATASKDNTAIVWRYNENSCKFDIYAKYIGHSAAVTAVGLPN 444 Query: 96 -----DGRWMYTGGEDCTARIW---------DLRSRNLQCQRIFQVNAPINCVCLHPNQA 141 ++ T D T + W D++ + IN + + PN + Sbjct: 445 IVSKGYPEFLLTASNDLTIKKWIIPKPTASMDVQIIKVSEYTRHAHEKDINALSVSPNDS 504 Query: 142 ELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTG 201 IW+L+ E + + + +A + +W+L Sbjct: 505 IFATASYDKTCKIWNLENGELEATLANHKRGLWDVSFCQYDKLLATSSGDKTVKIWSLDT 564 Query: 202 GIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIK 261 + HT +C F L +C AD KIW S+ + L Sbjct: 565 --------FSVMKTLEGHTNAVQRCSFINKQKQLISCGADGLIKIWDCSSGECLKTL--- 613 Query: 262 SGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLW 297 + +W + D IV+A +D + + W Sbjct: 614 -----DGHNNRLWALSTMNDGDMIVSADADGVFQFW 644 Score = 130 bits (327), Expect = 8e-31, Method: Composition-based stats. Identities = 37/257 (14%), Positives = 81/257 (31%), Gaps = 29/257 (11%) Query: 11 DPVILATAGYDHTVRFWQAHSGICTRTVQ----HQDSQVNALEVTPDRS------MIAAA 60 D + +ATA D+T W+ + C + + V A+ + S ++ A+ Sbjct: 399 DGLWIATASKDNTAIVWRYNENSCKFDIYAKYIGHSAAVTAVGLPNIVSKGYPEFLLTAS 458 Query: 61 GYQHIRMY---------DLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARI 111 I+ + D+ + + K+I ++ + T D T +I Sbjct: 459 NDLTIKKWIIPKPTASMDVQIIKVSE-YTRHAHEKDINALSVSPNDSIFATASYDKTCKI 517 Query: 112 WDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEV 171 W+L + L+ + + V L + IW L T + + Sbjct: 518 WNLENGELEA-TLANHKRGLWDVSFCQYDKLLATSSGDKTVKIWSLDTFSVMKTLEGHTN 576 Query: 172 SITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPD 231 ++ + + + G +W+ + G + H D Sbjct: 577 AVQRCSFINKQKQLISCGADGLIKIWDCSSG--------ECLKTLDGHNNRLWALSTMND 628 Query: 232 STLLATCSADQTCKIWR 248 ++ + AD + W+ Sbjct: 629 GDMIVSADADGVFQFWK 645 Score = 127 bits (320), Expect = 5e-30, Method: Composition-based stats. Identities = 65/389 (16%), Positives = 135/389 (34%), Gaps = 75/389 (19%) Query: 6 GTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVT-------PDRSMIA 58 G + S +LA+ + V+ W C T+Q S V L++ P ++++ Sbjct: 154 GQLNSKIWLLASGDTNGMVKVWDLVKRKCLHTLQEHTSAVRGLDIIEVPDNDEPSLNLLS 213 Query: 59 AAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDG---RWMYTGGEDCTARIWDLR 115 I ++D N ++ VN+ + S GF +DG R +YT G D ++ D Sbjct: 214 GGRDDIINLWDFNMKKKCKLLKTLPVNQQVESCGFLKDGDGKRIIYTAGGDAIFQLIDSE 273 Query: 116 SRNLQCQRIFQVNAPINCVCLHP--NQAELIVGDQSGAIHIWDLKTD--------HNEQL 165 S ++ +R + + + + P + +++ + + + +++ D Sbjct: 274 SGSV-LKRTNKPIEELFIIGVLPILSNSQMFLVLSDQTLQLINVEEDLKNDEDTIQVTSS 332 Query: 166 IPEPEVSITSAHI-DPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYAL 224 I I P+ + +A ++ + + + G E + + H Sbjct: 333 IAGNHGIIADMRYVGPELNKLALATNSPSLRIIPVPDLSGPEASLPLDVEIYEGHEDLLN 392 Query: 225 QCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIK----------SGNPGESSRGW-- 272 + D +AT S D T +WR + S ++ K G P S+G+ Sbjct: 393 SLDATEDGLWIATASKDNTAIVWRYNENSCKFDIYAKYIGHSAAVTAVGLPNIVSKGYPE 452 Query: 273 -----------------------------------------MWGCAFSGDSQYIVTASSD 291 + + S + TAS D Sbjct: 453 FLLTASNDLTIKKWIIPKPTASMDVQIIKVSEYTRHAHEKDINALSVSPNDSIFATASYD 512 Query: 292 NLARLWCVETGEIKREYGGHQKAVVCLAF 320 ++W +E GE++ H++ + ++F Sbjct: 513 KTCKIWNLENGELEATLANHKRGLWDVSF 541 Score = 117 bits (294), Expect = 5e-27, Method: Composition-based stats. Identities = 55/336 (16%), Positives = 119/336 (35%), Gaps = 36/336 (10%) Query: 13 VILATAGYDHTVRFWQAHSG-ICTRTVQHQDS--QVNALEVTPDRSMIAAAGYQHIRMYD 69 I+ TAG D + + SG + RT + + + L + + M Q +++ + Sbjct: 256 RIIYTAGGDAIFQLIDSESGSVLKRTNKPIEELFIIGVLPILSNSQMFLVLSDQTLQLIN 315 Query: 70 L------NSNNPNPIISYDGVNKNIASVGF-HEDGRWMYTGGEDCTARIWDLRSRN---- 118 + + + S G + IA + + + + + RI + + Sbjct: 316 VEEDLKNDEDTIQVTSSIAGNHGIIADMRYVGPELNKLALATNSPSLRIIPVPDLSGPEA 375 Query: 119 ---LQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIP----EPEV 171 L + +N + + + + +W + + I Sbjct: 376 SLPLDVEIYEGHEDLLNSLDATEDGLWIATASKDNTAIVWRYNENSCKFDIYAKYIGHSA 435 Query: 172 SITSAHIDPDAS-----YMAAVNSTGNCYVWNLTGGIGDEVTQLIP--KTKIPAHTRYAL 224 ++T+ + S ++ ++ W + Q+I + AH + Sbjct: 436 AVTAVGLPNIVSKGYPEFLLTASNDLTIKKWIIPKPTASMDVQIIKVSEYTRHAHEKDIN 495 Query: 225 QCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQY 284 SP+ ++ AT S D+TCKIW N L L+ + + +W +F + Sbjct: 496 ALSVSPNDSIFATASYDKTCKIWNLENGELEATLA--------NHKRGLWDVSFCQYDKL 547 Query: 285 IVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAF 320 + T+S D ++W ++T + + GH AV +F Sbjct: 548 LATSSGDKTVKIWSLDTFSVMKTLEGHTNAVQRCSF 583 Score = 111 bits (278), Expect = 4e-25, Method: Composition-based stats. Identities = 27/151 (17%), Positives = 62/151 (41%), Gaps = 6/151 (3%) Query: 7 TVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEV-TPDRSMIAAAGYQHI 65 +V + I ATA YD T + W +G T+ + + + D+ + ++G + + Sbjct: 498 SVSPNDSIFATASYDKTCKIWNLENGELEATLANHKRGLWDVSFCQYDKLLATSSGDKTV 557 Query: 66 RMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIF 125 +++ L++ + + + +G + F + + + G D +IWD S +C + Sbjct: 558 KIWSLDTFSV--MKTLEGHTNAVQRCSFINKQKQLISCGADGLIKIWDCSSG--ECLKTL 613 Query: 126 -QVNAPINCVCLHPNQAELIVGDQSGAIHIW 155 N + + + ++ D G W Sbjct: 614 DGHNNRLWALSTMNDGDMIVSADADGVFQFW 644 Score = 109 bits (272), Expect = 2e-24, Method: Composition-based stats. Identities = 50/331 (15%), Positives = 106/331 (32%), Gaps = 24/331 (7%) Query: 10 SDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRS---MIAAAGY--QH 64 S +LA G D ++ +G T + + +++L+ + + A+G Sbjct: 112 STSTLLAVGGTDGSIIVVDIENGYITHSFKGHGGTISSLKFYGQLNSKIWLLASGDTNGM 171 Query: 65 IRMYDLNSNNPNPIISYDGVNKNIASVGF------HEDGRWMYTGGEDCTARIWDLR-SR 117 ++++DL + + + E + +GG D +WD + Sbjct: 172 VKVWDLVKRKCLH--TLQEHTSAVRGLDIIEVPDNDEPSLNLLSGGRDDIINLWDFNMKK 229 Query: 118 NLQCQRIFQVNAPINCVCLHPNQ---AELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSIT 174 + + VN + + + + D ++ + +P + Sbjct: 230 KCKLLKTLPVNQQVESCGFLKDGDGKRIIYTAGGDAIFQLIDSESGSVLKRTNKPIEELF 289 Query: 175 SAHIDP--DASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRF-SPD 231 + P S M V S + N+ + ++ + + I + R+ P+ Sbjct: 290 IIGVLPILSNSQMFLVLSDQTLQLINVEEDLKNDEDTIQVTSSIAGNHGIIADMRYVGPE 349 Query: 232 STLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSD 291 LA + + +I + S E + + D +I TAS D Sbjct: 350 LNKLALATNSPSLRIIPVPDLSGPEASLPLDVEIYEGHEDLLNSLDATEDGLWIATASKD 409 Query: 292 NLARLWCVETGEI----KREYGGHQKAVVCL 318 N A +W +Y GH AV + Sbjct: 410 NTAIVWRYNENSCKFDIYAKYIGHSAAVTAV 440 Score = 82.9 bits (203), Expect = 2e-16, Method: Composition-based stats. Identities = 48/293 (16%), Positives = 101/293 (34%), Gaps = 32/293 (10%) Query: 29 AHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLNSNNPNPIISYDGVN-KN 87 ++ GI + S V + + + ++A I + DL + + + + Sbjct: 6 SYKGISLNPIYAGSSAVATV--SENGKILATPVLDEINIIDLTPGSRKILHKISNEDEQE 63 Query: 88 IASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGD 147 I ++ DG+++ + +I+ L++ + R ++++P + L VG Sbjct: 64 ITALKLTPDGQYLTYVSQAQLLKIFHLKTG--KVVRSMKISSPSYILDADSTSTLLAVGG 121 Query: 148 QSGAIHIWDLKTDHNEQLIPEPEVSITSAHI----DPDASYMAAVNSTGNCYVWNLTGGI 203 G+I + D++ + +I+S + +A+ ++ G VW+L Sbjct: 122 TDGSIIVVDIENGYITHSFKGHGGTISSLKFYGQLNSKIWLLASGDTNGMVKVWDLVKRK 181 Query: 204 GDEVTQLIPKTKIPAHTRYALQCRF--SPDST----LLATCSADQTCKIWRTSNFSLMTE 257 Q HT PD+ L + D +W + Sbjct: 182 CLHTLQ--------EHTSAVRGLDIIEVPDNDEPSLNLLSGGRDDIINLWDFNMKKKCKL 233 Query: 258 LSIKSGNPGESSRGWMWGCAFSGDS---QYIVTASSDNLARLWCVETGEIKRE 307 L N + C F D + I TA D + +L E+G + + Sbjct: 234 LKTLPVNQQ------VESCGFLKDGDGKRIIYTAGGDAIFQLIDSESGSVLKR 280 Score = 56.3 bits (134), Expect = 2e-08, Method: Composition-based stats. Identities = 22/145 (15%), Positives = 44/145 (30%), Gaps = 15/145 (10%) Query: 176 AHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLL 235 A + + +A + +LT G + ++ + + +PD L Sbjct: 23 ATVSENGKILATPVLD-EINIIDLTPGSRKILHKIS-----NEDEQEITALKLTPDGQYL 76 Query: 236 ATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLAR 295 S Q KI+ ++ + I + S + +D Sbjct: 77 TYVSQAQLLKIFHLKTGKVVRSMKI---------SSPSYILDADSTSTLLAVGGTDGSII 127 Query: 296 LWCVETGEIKREYGGHQKAVVCLAF 320 + +E G I + GH + L F Sbjct: 128 VVDIENGYITHSFKGHGGTISSLKF 152 >6J6H-n nrPDB Length = 455 Score = 165 bits (417), Expect = 2e-41, Method: Composition-based stats. Identities = 60/299 (20%), Positives = 108/299 (36%), Gaps = 22/299 (7%) Query: 35 TRTVQHQDSQVNALEVTPD-RSMIAAAGYQH-IRMYDLNSNNPNPIISYDGVNKNIASVG 92 R AL+ P +I + G H I+++D ++ + + G NK I ++ Sbjct: 155 IRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDF-YHDYECLRDFQGHNKPIKALR 213 Query: 93 FHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAI 152 F ED + + D + +IWD + ++ R+ + P + N E IVG + I Sbjct: 214 FTEDCQSFLSSSFDRSVKIWDTETGKVKT-RLHLNSTPADVESRPTNPHEFIVGLSNSKI 272 Query: 153 HIWDLKTDHNE---QLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQ 209 +D + N+ Q SI + PD S + + +W E Sbjct: 273 LHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIW--------ENQI 324 Query: 210 LIPKTKIPAHTRYAL-QCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGES 268 +P +I ++++ P S D + + K G S Sbjct: 325 NVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSL---KPKYKRHPKKIFKGHS 381 Query: 269 SRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKR--EYGGHQKAVVCLAFNDSVL 325 S G+ AFSGD +YI + S + W T + + G K + + ++ Sbjct: 382 SAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPG-NKPITQVDWHPQET 439 Score = 123 bits (309), Expect = 8e-29, Method: Composition-based stats. Identities = 44/296 (14%), Positives = 104/296 (35%), Gaps = 21/296 (7%) Query: 3 TSPGTVGSDPVILATAGYDHTVRFWQ-AHSGICTRTVQHQDSQVNALEVTPDRSMIAAAG 61 T+ + ++ + G DHT++ W H C R Q + + AL T D ++ Sbjct: 166 TALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSS 225 Query: 62 -YQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQ 120 + ++++D + + + ++ S ++ D S N Sbjct: 226 FDRSVKIWDTETGKVKTRLHLNSTPADVES-RPTNPHEFIVGLSNSKILHYDDRVSENQG 284 Query: 121 CQRIFQVN-APINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLI-PEPEVSITSAHI 178 + + + + I + P+ ++ I + + IW+ + + + I + S+ ++ Sbjct: 285 LVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNV 344 Query: 179 DPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHT--RYALQCRFSPDSTLLA 236 P +Y A + Y ++L + PK H+ Y + FS D + Sbjct: 345 HPSQNYFCAQSMDNRIYSFSLKPK-----YKRHPKKIFKGHSSAGYGISLAFSGDGRYIC 399 Query: 237 TCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSG--DSQYIVTASS 290 + + W + L+ + I P + + S+ I + ++ Sbjct: 400 SGDSKSRLFTWDWNTSRLLNNIKIPGNKP-------ITQVDWHPQETSKVICSGAA 448 >5UZ7-B nrPDB Length = 351 Score = 165 bits (417), Expect = 3e-41, Method: Composition-based stats. Identities = 50/293 (17%), Positives = 98/293 (33%), Gaps = 19/293 (6%) Query: 9 GSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHI-RM 67 G+D +L +A D + W +++ + + S V P + +A G +I + Sbjct: 75 GTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSI 134 Query: 68 YDLNSNNPNPIISYD--GVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIF 125 Y+L + N +S + G ++ F +D + + T D T +WD+ + Sbjct: 135 YNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQ-IVTSSGDTTCALWDIETGQQT-TTFT 192 Query: 126 QVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYM 185 + + L P+ + G + +WD++ Q E I + P+ + Sbjct: 193 GHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAF 252 Query: 186 AAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCK 245 A + C +++L Q + FS LL D C Sbjct: 253 ATGSDDATCRLFDL------RADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCN 306 Query: 246 IWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWC 298 +W L + + D + T S D+ ++W Sbjct: 307 VWDA--------LKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 351 Score = 148 bits (374), Expect = 2e-36, Method: Composition-based stats. Identities = 43/288 (14%), Positives = 100/288 (34%), Gaps = 21/288 (7%) Query: 35 TRTVQHQDSQVNALEVTPDRSMIAAAGYQ-HIRMYDLNSNNPNPIISYDGVNKNIASVGF 93 RT++ +++ A+ D ++ +A + ++D + N I + + + + Sbjct: 59 RRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLR--SSWVMTCAY 116 Query: 94 HEDGRWMYTGGEDCTARIWDLRSRNLQCQ---RIFQVNAPINCVCLHPNQAELIVGDQSG 150 G ++ GG D I++L++R + + ++C + +++ Sbjct: 117 APSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFL-DDNQIVTSSGDT 175 Query: 151 AIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQL 210 +WD++T + S + PD + + +W++ G Sbjct: 176 TCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREG-------- 227 Query: 211 IPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSR 270 + + H F P+ AT S D TC+++ + S ++ Sbjct: 228 MCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYS------HDNII 281 Query: 271 GWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCL 318 + +FS + ++ D +W + GH V CL Sbjct: 282 CGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCL 329 Score = 132 bits (331), Expect = 3e-31, Method: Composition-based stats. Identities = 30/151 (19%), Positives = 65/151 (43%), Gaps = 2/151 (1%) Query: 7 TVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQ-HI 65 ++ D + + D + + W G+C +T +S +NA+ P+ + A Sbjct: 202 SLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATC 261 Query: 66 RMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIF 125 R++DL ++ S+D + I SV F + GR + G +D +WD + + + Sbjct: 262 RLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDAL-KADRAGVLA 320 Query: 126 QVNAPINCVCLHPNQAELIVGDQSGAIHIWD 156 + ++C+ + + + G + IW+ Sbjct: 321 GHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 351 Score = 129 bits (324), Expect = 1e-30, Method: Composition-based stats. Identities = 44/201 (21%), Positives = 79/201 (39%), Gaps = 13/201 (6%) Query: 123 RIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDA 182 + A I + + L+ Q G + IWD T + IP + + P Sbjct: 61 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSG 120 Query: 183 SYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQ 242 +Y+A C ++NL G + ++ HT Y CRF D + T S D Sbjct: 121 NYVACGGLDNICSIYNLKTREG----NVRVSRELAGHTGYLSCCRFL-DDNQIVTSSGDT 175 Query: 243 TCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETG 302 TC +W T + +G+ + + + D++ V+ + D A+LW V G Sbjct: 176 TCALWDIETGQQTTTFTGHTGD--------VMSLSLAPDTRLFVSGACDASAKLWDVREG 227 Query: 303 EIKREYGGHQKAVVCLAFNDS 323 ++ + GH+ + + F + Sbjct: 228 MCRQTFTGHESDINAICFFPN 248 Score = 63.2 bits (152), Expect = 1e-10, Method: Composition-based stats. Identities = 24/116 (20%), Positives = 42/116 (36%), Gaps = 12/116 (10%) Query: 209 QLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGES 268 Q+ + + H + DS LL + S D IW + + Sbjct: 55 QMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWD--------SYTTNKVHAIPL 106 Query: 269 SRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGE----IKREYGGHQKAVVCLAF 320 W+ CA++ Y+ DN+ ++ ++T E + RE GH + C F Sbjct: 107 RSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRF 162 Score = 39.4 bits (90), Expect = 0.002, Method: Composition-based stats. Identities = 13/75 (17%), Positives = 28/75 (37%) Query: 249 TSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREY 308 T+N + + +++ ++ + DS+ +V+AS D +W T Sbjct: 45 TNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAI 104 Query: 309 GGHQKAVVCLAFNDS 323 V+ A+ S Sbjct: 105 PLRSSWVMTCAYAPS 119 >3JB9-g nrPDB Length = 558 Score = 162 bits (410), Expect = 2e-40, Method: Composition-based stats. Identities = 52/254 (20%), Positives = 95/254 (37%), Gaps = 24/254 (9%) Query: 7 TVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEV--TPDRSMIAAAGYQH 64 + D + +D T++ W G C + D N ++ PD+ AG Sbjct: 317 SFSQDGRSFLSTSFDKTIKLWDTELGKCLNCF-NSDRLTNCVKFQVDPDKPNEFLAGTAD 375 Query: 65 IRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRI 124 R+ + +P+ + +YD I S+ F E+G+ T +D + R W+ + Sbjct: 376 KRILQFDIRSPDIVQAYDHHLGGINSITFLENGKRFVTTSDDSSMRFWEYGT---PVPIK 432 Query: 125 FQVNAPINC---VCLHPNQAELIVGDQSGAIHIWDLKT---DHNEQLIPEPEVSITS--A 176 F + ++ V L PN + I+++ + +++ S S Sbjct: 433 FVADIAMHSMPRVALRPNGKSIACQSLDNCIYVYSAYEKYRQNKKKVFKGYSCSGYSLEV 492 Query: 177 HIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDST-LL 235 PD ++ + +S+GN W+ K+PAH+ F P T + Sbjct: 493 GFSPDGRFVFSGDSSGNACFWDWKT--------CKLMAKLPAHSGPVQSMAFHPQETSKV 544 Query: 236 ATCSA-DQTCKIWR 248 AT S D + K W Sbjct: 545 ATSSIVDGSIKYWD 558 Score = 162 bits (409), Expect = 2e-40, Method: Composition-based stats. Identities = 48/294 (16%), Positives = 106/294 (36%), Gaps = 18/294 (6%) Query: 37 TVQHQDSQVNALEVTP-DRSMIAAAGYQH-IRMYDLNSNNPNPIISYDGVNKNIASVGFH 94 T + ++ L P ++ + + I+++++ ++ + + ++ G + I + F Sbjct: 261 TWKGHTKGISCLRFFPISGHLLLSGSMDNQIKIWEV-YHDRSLLRTFQGHARPIRDLSFS 319 Query: 95 EDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLH--PNQA-ELIVGDQSGA 151 +DGR + D T ++WD + +C F + NCV P++ E + G Sbjct: 320 QDGRSFLSTSFDKTIKLWD--TELGKCLNCFNSDRLTNCVKFQVDPDKPNEFLAGTADKR 377 Query: 152 IHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLI 211 I +D+++ Q I S + + + W + + Sbjct: 378 ILQFDIRSPDIVQAYDHHLGGINSITFLENGKRFVTTSDDSSMRFWEYGTPVPIK----- 432 Query: 212 PKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRG 271 I H+ + P+ +A S D ++ + + G S G Sbjct: 433 FVADIAMHSMP--RVALRPNGKSIACQSLDNCIYVYSAYEKYRQNKKKVFKGY---SCSG 487 Query: 272 WMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDSVL 325 + FS D +++ + S A W +T ++ + H V +AF+ Sbjct: 488 YSLEVGFSPDGRFVFSGDSSGNACFWDWKTCKLMAKLPAHSGPVQSMAFHPQET 541 >4V7E-Bg nrPDB Length = 380 Score = 161 bits (408), Expect = 3e-40, Method: Composition-based stats. Identities = 54/268 (20%), Positives = 93/268 (34%), Gaps = 24/268 (8%) Query: 9 GSDPVILATAGYDHTVRFWQAHSGI-------CTRTVQHQDSQVNALEVTPDRS--MIAA 59 + +A G D + S +R + ++ + PD+ +I Sbjct: 117 APNGQSVACGGLDSACSIFNLSSQADRDGNMPVSRVLTGHKGYASSCQYVPDQETRLITG 176 Query: 60 AGYQHIRMYDLNSNNPNPIISYD---GVNKNIASVGFHE-DGRWMYTGGEDCTARIWDLR 115 +G Q ++D+ + I + G ++ S+ + + +G D T R+WDLR Sbjct: 177 SGDQTCVLWDVTTGQRISIFGSEFPSGHTADVLSLSINSLNANMFISGSCDTTVRLWDLR 236 Query: 116 SRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEV---- 171 + + IN V P+ G G ++D++T H Q+ Sbjct: 237 ITSRAVRTYHGHEGDINSVKFFPDGQRFGTGSDDGTCRLFDMRTGHQLQVYNREPDRNDN 296 Query: 172 ---SITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRF 228 +TS + A S G+CYVW+ L T +H Sbjct: 297 ELPIVTSVAFSISGRLLFAGYSNGDCYVWD----TLLAEMVLNLGTLQNSHEGRISCLGL 352 Query: 229 SPDSTLLATCSADQTCKIWRTSNFSLMT 256 S D + L T S D+ KIW S + Sbjct: 353 SSDGSALCTGSWDKNLKIWAFSGHRKIV 380 Score = 153 bits (386), Expect = 1e-37, Method: Composition-based stats. Identities = 54/323 (16%), Positives = 109/323 (33%), Gaps = 26/323 (8%) Query: 16 ATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLNSNNP 75 + T + +C RT+Q +V +L+ TP+++ I +A R+ N+ Sbjct: 40 YSKAQGRTAVSFNPTDLVCCRTLQGHSGKVYSLDWTPEKNWIVSASQDG-RLIVWNALTS 98 Query: 76 NPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDL-----RSRNLQCQRIF-QVNA 129 + + F +G+ + GG D I++L R N+ R+ Sbjct: 99 QKTHAIKLHCPWVMECAFAPNGQSVACGGLDSACSIFNLSSQADRDGNMPVSRVLTGHKG 158 Query: 130 PINCVCLHPN-QAELIVGDQSGAIHIWDLKTDHNEQLI-----PEPEVSITSAHIDP-DA 182 + P+ + LI G +WD+ T + + S I+ +A Sbjct: 159 YASSCQYVPDQETRLITGSGDQTCVLWDVTTGQRISIFGSEFPSGHTADVLSLSINSLNA 218 Query: 183 SYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQ 242 + + + +W+L H +F PD T S D Sbjct: 219 NMFISGSCDTTVRLWDLRI-------TSRAVRTYHGHEGDINSVKFFPDGQRFGTGSDDG 271 Query: 243 TCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETG 302 TC+++ + + + + ++ + AFS + + S+ +W Sbjct: 272 TCRLFDMRTGHQLQVYNREP-DRNDNELPIVTSVAFSISGRLLFAGYSNGDCYVWDTLLA 330 Query: 303 EIKREYGG----HQKAVVCLAFN 321 E+ G H+ + CL + Sbjct: 331 EMVLNLGTLQNSHEGRISCLGLS 353 Score = 118 bits (296), Expect = 3e-27, Method: Composition-based stats. Identities = 42/214 (19%), Positives = 77/214 (35%), Gaps = 18/214 (8%) Query: 8 VGSDPVILATAGYDHTVRFWQAHSGICTRTVQ-----HQDSQVNALEVTP-DRSMIAAAG 61 V L T D T W +G + V +L + + +M + Sbjct: 166 VPDQETRLITGSGDQTCVLWDVTTGQRISIFGSEFPSGHTADVLSLSINSLNANMFISGS 225 Query: 62 YQ-HIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQ 120 +R++DL + + +Y G +I SV F DG+ TG +D T R++D+R+ + Sbjct: 226 CDTTVRLWDLRITS-RAVRTYHGHEGDINSVKFFPDGQRFGTGSDDGTCRLFDMRTGHQL 284 Query: 121 CQRIFQVNAP------INCVCLHPNQAELIVGDQSGAIHIWDLK----TDHNEQLIPEPE 170 + + + V + L G +G ++WD + L E Sbjct: 285 QVYNREPDRNDNELPIVTSVAFSISGRLLFAGYSNGDCYVWDTLLAEMVLNLGTLQNSHE 344 Query: 171 VSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIG 204 I+ + D S + + N +W +G Sbjct: 345 GRISCLGLSSDGSALCTGSWDKNLKIWAFSGHRK 378 Score = 116 bits (290), Expect = 1e-26, Method: Composition-based stats. Identities = 39/205 (19%), Positives = 77/205 (37%), Gaps = 7/205 (3%) Query: 121 CQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDP 180 C+ + + + + P + ++ Q G + +W+ T I + P Sbjct: 59 CRTLQGHSGKVYSLDWTPEKNWIVSASQDGRLIVWNALTSQKTHAIKLHCPWVMECAFAP 118 Query: 181 DASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDS-TLLATCS 239 + +A C ++NL+ D + + H YA C++ PD T L T S Sbjct: 119 NGQSVACGGLDSACSIFNLSSQA-DRDGNMPVSRVLTGHKGYASSCQYVPDQETRLITGS 177 Query: 240 ADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSG-DSQYIVTASSDNLARLWC 298 DQTC +W + ++ + + + + + ++ ++ S D RLW Sbjct: 178 GDQTCVLWDVTTGQRISIFGSEFPS---GHTADVLSLSINSLNANMFISGSCDTTVRLWD 234 Query: 299 VE-TGEIKREYGGHQKAVVCLAFND 322 + T R Y GH+ + + F Sbjct: 235 LRITSRAVRTYHGHEGDINSVKFFP 259 Score = 104 bits (259), Expect = 6e-23, Method: Composition-based stats. Identities = 29/163 (17%), Positives = 55/163 (33%), Gaps = 10/163 (6%) Query: 3 TSPGTVGSDPVILATAGYDHTVRFWQAH-SGICTRTVQHQDSQVNALEVTPDRSMIAAAG 61 S + + + D TVR W + RT + +N+++ PD Sbjct: 209 LSLSINSLNANMFISGSCDTTVRLWDLRITSRAVRTYHGHEGDINSVKFFPDGQRFGTGS 268 Query: 62 YQ-HIRMYDLNSNNPNPII-----SYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLR 115 R++D+ + + + D + SV F GR ++ G + +WD Sbjct: 269 DDGTCRLFDMRTGHQLQVYNREPDRNDNELPIVTSVAFSISGRLLFAGYSNGDCYVWDTL 328 Query: 116 SRNLQC---QRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIW 155 + I+C+ L + + L G + IW Sbjct: 329 LAEMVLNLGTLQNSHEGRISCLGLSSDGSALCTGSWDKNLKIW 371 >6Q8F-A nrPDB Length = 514 Score = 160 bits (405), Expect = 6e-40, Method: Composition-based stats. Identities = 53/253 (20%), Positives = 99/253 (39%), Gaps = 26/253 (10%) Query: 9 GSDPVILATAGYDHTVRFWQAHSGICTRTVQ-HQDSQVNALEVTPDRSMIAAAG-YQHIR 66 D +LAT D ++ W+ SG C R + V L + D S I +A Q IR Sbjct: 274 SRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIR 333 Query: 67 MYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQ 126 ++ L S + + G + + F +DG ++ + D T +IW++++ +C F+ Sbjct: 334 IHGLKSGKT--LKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKT--TECSNTFK 389 Query: 127 -------VNAPINCVCLHP-NQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVS---ITS 175 + +N V L P N +V ++S + I +++ + + Sbjct: 390 SLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQ-GQIVRSFSSGKREGGDFVC 448 Query: 176 AHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLL 235 + P ++ V VT + +T + H + + P L+ Sbjct: 449 CALSPRGEWIYCVGED-------FVLYCFSTVTGKLERT-LTVHEKDVIGIAHHPHQNLI 500 Query: 236 ATCSADQTCKIWR 248 AT S D K+W+ Sbjct: 501 ATYSEDGLLKLWK 513 Score = 157 bits (397), Expect = 5e-39, Method: Composition-based stats. Identities = 52/293 (17%), Positives = 104/293 (35%), Gaps = 20/293 (6%) Query: 40 HQDSQVNALEVTPDRSMIAAAG-YQHIRMYDLNSNNPNPIISYDGVN------KNIASVG 92 Q S V +PD + I +++ + + Y + + + Sbjct: 213 GQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMC 272 Query: 93 FHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQ--VNAPINCVCLHPNQAELIVGDQSG 150 F D + TG +D ++W ++S QC R F+ + + C+ + ++++ Sbjct: 273 FSRDTEMLATGAQDGKIKVWKIQSG--QCLRRFERAHSKGVTCLSFSKDSSQILSASFDQ 330 Query: 151 AIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQL 210 I I LK+ + + A D Y+ + +S G +WN+ + Sbjct: 331 TIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKS 390 Query: 211 IPKTKIPAHTRYALQCRFSP-DSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESS 269 + T T P + C+ T I M ++S + G+ Sbjct: 391 LGSTAGTDIT--VNSVILLPKNPEHFVVCNRSNTVVIMN------MQGQIVRSFSSGKRE 442 Query: 270 RGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFND 322 G CA S ++I D + + TG+++R H+K V+ +A + Sbjct: 443 GGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHP 495 Score = 153 bits (386), Expect = 1e-37, Method: Composition-based stats. Identities = 52/312 (16%), Positives = 100/312 (32%), Gaps = 32/312 (10%) Query: 2 NTSPGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQ--------DSQVNALEVTPD 53 + D L T D + W +G + +++Q D V + + D Sbjct: 217 HVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRD 276 Query: 54 RSMIAAAGYQ-HIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIW 112 M+A I+++ + S +K + + F +D + + D T RI Sbjct: 277 TEMLATGAQDGKIKVWKIQSGQCLRRFE-RAHSKGVTCLSFSKDSSQILSASFDQTIRIH 335 Query: 113 DLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIP----- 167 L+S + ++ +N + +I G + IW++KT Sbjct: 336 GLKSGKT-LKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGST 394 Query: 168 -EPEVSITSAHIDPDAS-YMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQ 225 ++++ S + P + N + + N+ G I + + + Sbjct: 395 AGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKREG------GDFVC 448 Query: 226 CRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYI 285 C SP + D + T L L++ + G A I Sbjct: 449 CALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTV--------HEKDVIGIAHHPHQNLI 500 Query: 286 VTASSDNLARLW 297 T S D L +LW Sbjct: 501 ATYSEDGLLKLW 512 Score = 134 bits (337), Expect = 6e-32, Method: Composition-based stats. Identities = 40/196 (20%), Positives = 71/196 (36%), Gaps = 23/196 (11%) Query: 122 QRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEP--------EVSI 173 F + + C P+ L+ G G I +W+ T + + + ++ Sbjct: 209 HIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAV 268 Query: 174 TSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDST 233 D +A G VW + G + AH++ FS DS+ Sbjct: 269 LCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFE-------RAHSKGVTCLSFSKDSS 321 Query: 234 LLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNL 293 + + S DQT +I + + E S E+ F+ D YI++ASSD Sbjct: 322 QILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEA--------TFTQDGHYIISASSDGT 373 Query: 294 ARLWCVETGEIKREYG 309 ++W ++T E + Sbjct: 374 VKIWNMKTTECSNTFK 389 >5Z56-q nrPDB Length = 504 Score = 160 bits (404), Expect = 1e-39, Method: Composition-based stats. Identities = 51/293 (17%), Positives = 102/293 (34%), Gaps = 21/293 (7%) Query: 9 GSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQ-HIRM 67 SD + T G D V + S T++ +V ++ P + ++ +A IR+ Sbjct: 231 PSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRI 290 Query: 68 YDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQV 127 + + + + ++ + + H G ++ + +D D+++ + + + Sbjct: 291 WSVPNASCVQVV--RAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDET 348 Query: 128 NA-PINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMA 186 + + C HP+ G I IWDLK N P ITS + Y+A Sbjct: 349 SGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLA 408 Query: 187 AVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKI 246 + +W+L + QL + F T LA D I Sbjct: 409 TAADDSSVKLWDLRKLKNFKTLQL-------DNNFEVKSLIFDQSGTYLALGGTDVQIYI 461 Query: 247 WRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCV 299 ++ + + SG G AF +++I + D + + + Sbjct: 462 --CKQWTEILHFTEHSGLTT--------GVAFGHHAKFIASTGMDRSLKFYSL 504 Score = 145 bits (366), Expect = 2e-35, Method: Composition-based stats. Identities = 44/272 (16%), Positives = 86/272 (31%), Gaps = 21/272 (7%) Query: 51 TPDRSMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTAR 110 D + I G + + ++ + + G K + SV FH +++ D T R Sbjct: 231 PSDTNKILTGGADK-NVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIR 289 Query: 111 IWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPE 170 IW + + + Q + + + + LH L+ D++T + + Sbjct: 290 IWSVPNASC-VQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDET 348 Query: 171 V--SITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRF 228 S+T A PD +W+L P H+ F Sbjct: 349 SGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTN--------VANFPGHSGPITSIAF 400 Query: 229 SPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTA 288 S + LAT + D + K+W L + + + F Y+ Sbjct: 401 SENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFE-------VKSLIFDQSGTYLALG 453 Query: 289 SSDNLARLWCVETGEIKREYGGHQKAVVCLAF 320 +D +++ + + H +AF Sbjct: 454 GTD--VQIYICKQWTEILHFTEHSGLTTGVAF 483 Score = 107 bits (266), Expect = 8e-24, Method: Composition-based stats. Identities = 30/192 (15%), Positives = 65/192 (33%), Gaps = 15/192 (7%) Query: 131 INCVCLHPNQAE-LIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVN 189 I + L P+ ++ G + ++D ++ + +TS P + + + Sbjct: 224 ILALDLCPSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSAS 283 Query: 190 STGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRT 249 +W++ +V + AH L + S DQ W Sbjct: 284 PDATIRIWSVPNASCVQV--------VRAHESAVTGLSLHATGDYLLSSSDDQ---YWA- 331 Query: 250 SNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYG 309 FS + + + E+S + F D T + D+ ++W ++ + Sbjct: 332 --FSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFP 389 Query: 310 GHQKAVVCLAFN 321 GH + +AF+ Sbjct: 390 GHSGPITSIAFS 401 Score = 78.7 bits (192), Expect = 4e-15, Method: Composition-based stats. Identities = 20/153 (13%), Positives = 50/153 (32%), Gaps = 5/153 (3%) Query: 6 GTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQ-H 64 D +I T D ++ W + ++ + + +A A Sbjct: 356 AQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSS 415 Query: 65 IRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRI 124 ++++DL + D N + S+ F + G ++ GG D +I+ + + Sbjct: 416 VKLWDLRKLKNFKTLQLD-NNFEVKSLIFDQSGTYLALGGTD--VQIYICKQWT-EILHF 471 Query: 125 FQVNAPINCVCLHPNQAELIVGDQSGAIHIWDL 157 + + V + + ++ + L Sbjct: 472 TEHSGLTTGVAFGHHAKFIASTGMDRSLKFYSL 504 Score = 66.7 bits (161), Expect = 1e-11, Method: Composition-based stats. Identities = 19/103 (18%), Positives = 37/103 (35%), Gaps = 9/103 (8%) Query: 222 YALQCRFSP-DSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSG 280 L P D+ + T AD+ ++ S+ ++ L + + F Sbjct: 223 GILALDLCPSDTNKILTGGADKNVVVFDKSSEQILATLKGHT--------KKVTSVVFHP 274 Query: 281 DSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDS 323 + +AS D R+W V + H+ AV L+ + + Sbjct: 275 SQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHAT 317 Score = 49.4 bits (116), Expect = 2e-06, Method: Composition-based stats. Identities = 14/65 (21%), Positives = 25/65 (38%) Query: 259 SIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCL 318 + G S G + D+ I+T +D ++ + +I GH K V + Sbjct: 211 ASHVGLHSASIPGILALDLCPSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSV 270 Query: 319 AFNDS 323 F+ S Sbjct: 271 VFHPS 275 >5OQL-J nrPDB Length = 912 Score = 159 bits (401), Expect = 2e-39, Method: Composition-based stats. Identities = 71/387 (18%), Positives = 134/387 (34%), Gaps = 80/387 (20%) Query: 6 GTVGSDPVILATAGYDHTVRFWQAHS---------GICTRTVQ----HQDSQVNALEVTP 52 + ++ A D T+ ++ S GI + D ++ + P Sbjct: 325 AVSLPERSLILCAQADFTLVLYRVPSPADVVSSSEGILLEPFRRISGTHDEILDLTYILP 384 Query: 53 DRSMIAAAG-YQHIRMYDLN---------------SNNPNPIISYDGVNKNIASVGFHED 96 D+SM+A A + IR+ + S + + G + S+ Sbjct: 385 DQSMMAIATNSEDIRIVSVKDAQAYSEDNAECRSGSYFGHDVALLKGHEDIVMSLDVDWS 444 Query: 97 GRWMYTGGEDCTARIW--DLRSRNLQCQRIFQVN-------------APINCVCL----- 136 G W+ +G +D TAR+W D + + C +F + P N Sbjct: 445 GHWIASGSKDNTARLWRVDPANNSYTCYAVFTGHLESVGAVALPKVVPPANSEAFKNPLD 504 Query: 137 HPNQAELIVGDQSGAIHIWDL-----KTDHNEQLIP--EPEVSITSAHIDPDASYMAAVN 189 HP A LI G Q + D+ K + + I + I P+ A+ + Sbjct: 505 HP-PAFLISGSQDRFVQKRDIPRQLQKGGKLTSSLRRLAHDKDINALDISPNGKLFASAS 563 Query: 190 STGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDST--------------LL 235 +W++ +L + + H R RF+P +T ++ Sbjct: 564 QDKTVKIWDVE--------KLEVQGILRGHKRGVWTVRFAPLNTPVIQGEQGSVSGRGVV 615 Query: 236 ATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMW-GCAFSGDSQYIVTASSDNLA 294 T S D+T K+W S+++ + S N + + + + +A +D L Sbjct: 616 LTGSGDKTIKLWNLSDYTCIRTFEGHSHNVLKVVWLHISRDDSITKTKVQFASAGADTLV 675 Query: 295 RLWCVETGEIKREYGGHQKAVVCLAFN 321 ++W TGE + H+ + LA + Sbjct: 676 KVWDANTGETECTLDNHEDRLWTLAVH 702 Score = 127 bits (318), Expect = 7e-30, Method: Composition-based stats. Identities = 42/309 (13%), Positives = 100/309 (32%), Gaps = 66/309 (21%) Query: 38 VQHQDSQVNALEVTPDRSMIAAAGYQHI-RMY--DLNSNNPNPIISYDGVNKNIASVGF- 93 ++ + V +L+V IA+ + R++ D +N+ + G +++ +V Sbjct: 429 LKGHEDIVMSLDVDWSGHWIASGSKDNTARLWRVDPANNSYTCYAVFTGHLESVGAVALP 488 Query: 94 ----------------HEDGRWMYTGGEDCTARIWDLRSRNLQCQRI------FQVNAPI 131 H ++ +G +D + D+ + + ++ + I Sbjct: 489 KVVPPANSEAFKNPLDHPPA-FLISGSQDRFVQKRDIPRQLQKGGKLTSSLRRLAHDKDI 547 Query: 132 NCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDAS-------- 183 N + + PN Q + IWD++ + ++ + + + P + Sbjct: 548 NALDISPNGKLFASASQDKTVKIWDVEKLEVQGILRGHKRGVWTVRFAPLNTPVIQGEQG 607 Query: 184 ------YMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRF---SPDSTL 234 + + +WNL+ H+ L+ + S D ++ Sbjct: 608 SVSGRGVVLTGSGDKTIKLWNLSDYT--------CIRTFEGHSHNVLKVVWLHISRDDSI 659 Query: 235 ------LATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTA 288 A+ AD K+W + L ++ +W A + + +A Sbjct: 660 TKTKVQFASAGADTLVKVWDANTGETECTL--------DNHEDRLWTLAVHSKTNILASA 711 Query: 289 SSDNLARLW 297 SD+ W Sbjct: 712 GSDSKVTFW 720 Score = 117 bits (294), Expect = 5e-27, Method: Composition-based stats. Identities = 58/404 (14%), Positives = 126/404 (31%), Gaps = 101/404 (25%) Query: 15 LATAGYDHTVRFWQAHS-------GICTRTVQHQDSQVNALEVTPDRSMIAAAGYQ---H 64 LA D +R + + R + +S V + +P++ + + Sbjct: 198 LAWGTQDGRIRIFDLYKRTTTPVYADPKRKKEAHESNVQCIAYSPEQHALLSGSRDKTMT 257 Query: 65 IRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQR- 123 + ++ P++ ++ + SVGF +G+WMY+ G RIWD + + ++ Sbjct: 258 LWLWRDGIWQGTPMLRHE----LLESVGFLNEGKWMYSAGTSGVLRIWDTTTHHEITKKQ 313 Query: 124 -------------------------------IFQVNAPINCVC----------------- 135 +++V +P + V Sbjct: 314 DAKSEGEAILSAVSLPERSLILCAQADFTLVLYRVPSPADVVSSSEGILLEPFRRISGTH 373 Query: 136 --------LHPNQAELIVGDQSGAIHIWDLKT-----------------DHNEQLIPEPE 170 + P+Q+ + + S I I +K H+ L+ E Sbjct: 374 DEILDLTYILPDQSMMAIATNSEDIRIVSVKDAQAYSEDNAECRSGSYFGHDVALLKGHE 433 Query: 171 VSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSP 230 + S +D ++A+ + +W + + + + AL P Sbjct: 434 DIVMSLDVDWSGHWIASGSKDNTARLWRVDPANNSYTCYAVFTGHLESVGAVALPKVVPP 493 Query: 231 DST------------LLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAF 278 ++ L + S D+ + L + S + + Sbjct: 494 ANSEAFKNPLDHPPAFLISGSQDRFVQKRDIP-RQLQKGGKLTSSLRRLAHDKDINALDI 552 Query: 279 SGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFND 322 S + + +AS D ++W VE E++ GH++ V + F Sbjct: 553 SPNGKLFASASQDKTVKIWDVEKLEVQGILRGHKRGVWTVRFAP 596 Score = 107 bits (266), Expect = 9e-24, Method: Composition-based stats. Identities = 61/382 (15%), Positives = 110/382 (28%), Gaps = 82/382 (21%) Query: 8 VGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRM 67 V +LAT D ++ W G T TV V+AL + A Q Sbjct: 119 VDRTSTLLATGAADGAIKIWDIIGGYVTHTVSGPSVLVSALHFF---EIAVTAESQ---- 171 Query: 68 YDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQC------ 121 +SN S G N + + + G +D RI+DL R Sbjct: 172 ---SSNKKPKKGSRKGQNDDADEIA---SRFRLAWGTQDGRIRIFDLYKRTTTPVYADPK 225 Query: 122 QRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPD 181 ++ + + C+ P Q L+ G + + +W + + + S + Sbjct: 226 RKKEAHESNVQCIAYSPEQHALLSGSRDKTMTLWLWRDGIWQGTPMLRHELLESVGFLNE 285 Query: 182 ASYMAAVNSTGNCYVWNLTGGIGDEVTQ-------------------------------- 209 +M + ++G +W+ T Q Sbjct: 286 GKWMYSAGTSGVLRIWDTTTHHEITKKQDAKSEGEAILSAVSLPERSLILCAQADFTLVL 345 Query: 210 -----------------LIPKTKIPAHTRYALQCRF-SPDSTLLATCSADQTCKI----- 246 L P +I L + PD +++A + + +I Sbjct: 346 YRVPSPADVVSSSEGILLEPFRRISGTHDEILDLTYILPDQSMMAIATNSEDIRIVSVKD 405 Query: 247 ---WRTSNFSLMT-ELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETG 302 + N + + + +I + S DN ARLW V+ Sbjct: 406 AQAYSEDNAECRSGSYFGHDVALLKGHEDIVMSLDVDWSGHWIASGSKDNTARLWRVDPA 465 Query: 303 E----IKREYGGHQKAVVCLAF 320 + GH ++V +A Sbjct: 466 NNSYTCYAVFTGHLESVGAVAL 487 Score = 102 bits (255), Expect = 2e-22, Method: Composition-based stats. Identities = 49/292 (16%), Positives = 97/292 (33%), Gaps = 48/292 (16%) Query: 47 ALEVTPDRSMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGED 106 ++ + ++A+ ++ + +LN+ + G + I+++ G + Sbjct: 25 SVALENGARILASTLGENAILTELNTGK--RLAEIQGDGEPISTLTITPSGSHLIVCSRS 82 Query: 107 CTARIW------DLRSRNLQCQRIFQVNA-PINCVCLHPNQAELIVGDQSGAIHIWDLKT 159 T RI+ D S R + +A P+ + + L G GAI IWD+ Sbjct: 83 LTMRIYSLAISPDYDSVEPTLVRTTKPHATPVVVLAVDRTSTLLATGAADGAIKIWDIIG 142 Query: 160 DHNEQLIPEPEVSITSAHID------------------------------PDASYMAAVN 189 + + P V +++ H +A Sbjct: 143 GYVTHTVSGPSVLVSALHFFEIAVTAESQSSNKKPKKGSRKGQNDDADEIASRFRLAWGT 202 Query: 190 STGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRT 249 G +++L V PK K AH +SP+ L + S D+T +W Sbjct: 203 QDGRIRIFDLYKRTTTPVYA-DPKRKKEAHESNVQCIAYSPEQHALLSGSRDKTMTLWLW 261 Query: 250 SNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVET 301 + I G P + F + +++ +A + + R+W T Sbjct: 262 RDG-------IWQGTPMLRHE-LLESVGFLNEGKWMYSAGTSGVLRIWDTTT 305 Score = 96.0 bits (237), Expect = 2e-20, Method: Composition-based stats. Identities = 24/172 (13%), Positives = 58/172 (33%), Gaps = 27/172 (15%) Query: 8 VGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTP--------------- 52 + + + A+A D TV+ W ++ V + P Sbjct: 552 ISPNGKLFASASQDKTVKIWDVEKLEVQGILRGHKRGVWTVRFAPLNTPVIQGEQGSVSG 611 Query: 53 DRSMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGR---------WMYTG 103 ++ +G + I++++L ++ I +++G + N+ V + R + Sbjct: 612 RGVVLTGSGDKTIKLWNL--SDYTCIRTFEGHSHNVLKVVWLHISRDDSITKTKVQFASA 669 Query: 104 GEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIW 155 G D ++WD + +C + + + +H L + W Sbjct: 670 GADTLVKVWDANTGETEC-TLDNHEDRLWTLAVHSKTNILASAGSDSKVTFW 720 Score = 67.9 bits (164), Expect = 5e-12, Method: Composition-based stats. Identities = 35/213 (16%), Positives = 65/213 (30%), Gaps = 29/213 (13%) Query: 139 NQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWN 198 N A ++ + +L T I I++ I P S++ + + +++ Sbjct: 30 NGARILASTLGENAILTELNTGKRLAEIQGDGEPISTLTITPSGSHLIVCSRSLTMRIYS 89 Query: 199 LTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTEL 258 L + + H + STLLAT +AD KIW + + Sbjct: 90 LAISPDYDSVEPTLVRTTKPHATPVVVLAVDRTSTLLATGAADGAIKIWDIIGGYVTHTV 149 Query: 259 SIKSGNPGESSRGWMWGCAFSGDSQ----------------------YIVTASSDNLARL 296 S S + A S S + + D R+ Sbjct: 150 SGPSVLVSALHFFEIAVTAESQSSNKKPKKGSRKGQNDDADEIASRFRLAWGTQDGRIRI 209 Query: 297 WCVETGEI-------KREYGGHQKAVVCLAFND 322 + + KR+ H+ V C+A++ Sbjct: 210 FDLYKRTTTPVYADPKRKKEAHESNVQCIAYSP 242 >3FM0-A nrPDB Length = 345 Score = 158 bits (399), Expect = 3e-39, Method: Composition-based stats. Identities = 48/311 (15%), Positives = 108/311 (34%), Gaps = 20/311 (6%) Query: 12 PVILATAGYDHTVRFW--QAHSGICTRTV-QHQDSQVNALEVTPDRSMIAAAGYQHIR-M 67 +LA+ G D +R W + S IC + + V + +P + +A+A + + Sbjct: 28 GTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASFDATTCI 87 Query: 68 YDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQ--CQRIF 125 + N ++ + + +G + SV + G + T D + +W++ + + Sbjct: 88 WKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLN 147 Query: 126 QVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDH--NEQLIPEPEVSITSAHIDPDAS 183 + V HP+Q L + ++ + D + E ++ S DP Sbjct: 148 SHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQ 207 Query: 184 YMAAVNSTGNCYVW---------NLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTL 234 +A+ + +W + D + I T H+R + + Sbjct: 208 RLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCIC-TLSGFHSRTIYDIAWCQLTGA 266 Query: 235 LATCSADQTCKIWRTS-NFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQ-YIVTASSDN 292 LAT D ++++ N + + ++ + A++ + + S D Sbjct: 267 LATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPKEPGLLASCSDDG 326 Query: 293 LARLWCVETGE 303 W + E Sbjct: 327 EVAFWKYQRPE 337 Score = 144 bits (362), Expect = 6e-35, Method: Composition-based stats. Identities = 50/317 (15%), Positives = 111/317 (35%), Gaps = 31/317 (9%) Query: 34 CTRTVQHQDSQVNALEVTPDRSMIAA-AGYQHIRMYDLNSNN--PNPIISYDGVNKNIAS 90 R H DS+ L P +++A+ G + IR++ ++ ++S +G + + Sbjct: 8 LGRVPAHPDSRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLS-EGHQRTVRK 66 Query: 91 VGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIF-QVNAPINCVCLHPNQAELIVGDQS 149 V + G ++ + D T IW + +C + V P+ L + Sbjct: 67 VAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRD 126 Query: 150 GAIHIWDLKTD---HNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDE 206 ++ +W++ + ++ + P +A+ + ++ +E Sbjct: 127 KSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLY------REE 180 Query: 207 VTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPG 266 + + H F P LA+CS D+T +IWR ++ +P Sbjct: 181 EDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPS 240 Query: 267 ES--------SRGWMWGCAFSGDSQYIVTASSDNLARLW--CVETGEIKREYG------- 309 ++ A+ + + TA D+ R++ + + + Sbjct: 241 WKCICTLSGFHSRTIYDIAWCQLTGALATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQ 300 Query: 310 GHQKAVVCLAFNDSVLG 326 H + V C+A+N G Sbjct: 301 AHSQDVNCVAWNPKEPG 317 Score = 104 bits (259), Expect = 6e-23, Method: Composition-based stats. Identities = 33/218 (15%), Positives = 67/218 (30%), Gaps = 29/218 (13%) Query: 9 GSDPVILATAGYDHTVRFWQAHS---GICTRTVQHQDSQVNALEVTPDRSMIAAAG-YQH 64 +LAT D +V W+ C + V + P + ++A+A Sbjct: 114 APSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDT 173 Query: 65 IRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIW------------ 112 +++Y ++ + +G + S+ F G+ + + +D T RIW Sbjct: 174 VKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVA 233 Query: 113 -DLRSRNLQCQRIFQ--VNAPINCVCLHPNQAELIVGDQSGAIHIW--DLKTDH------ 161 + +C + I + L AI ++ D +D Sbjct: 234 CSGSDPSWKCICTLSGFHSRTIYDIAWCQLTGALATACGDDAIRVFQEDPNSDPQQPTFS 293 Query: 162 -NEQLIPEPEVSITSAHIDPDAS-YMAAVNSTGNCYVW 197 L + +P +A+ + G W Sbjct: 294 LTAHLHQAHSQDVNCVAWNPKEPGLLASCSDDGEVAFW 331 >5K1B-B nrPDB Length = 677 Score = 158 bits (398), Expect = 5e-39, Method: Composition-based stats. Identities = 59/314 (18%), Positives = 120/314 (38%), Gaps = 27/314 (8%) Query: 7 TVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAG-YQHI 65 + + L +A D TV+ W AH G C T++ V AL D+ ++A+AG + I Sbjct: 82 VLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQI 141 Query: 66 RMYDLNS-------NNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRN 118 ++D+N+ NN S G +I S+ ++ G + +G + R+WD R+ Sbjct: 142 FLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRT-C 200 Query: 119 LQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHI 178 + ++ + + L+ + + + G G I +W L + + + + Sbjct: 201 AKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQV 260 Query: 179 DPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATC 238 + +++ + Y T ++ LI + K P + P + +AT Sbjct: 261 NDAFTHVYSGGRDRKIY---CTDLRNPDIRVLICEEKAPVLKMELDRSADPPPAIWVATT 317 Query: 239 SADQTCKIWRT-----------SNFSLMTELSIKSGNPGESSRGW--MWGCAFSGDSQYI 285 + T W + ++ P + +G + C D ++I Sbjct: 318 KS--TVNKWTLKGIHNFRASGDYDNDCTNPITPLCTQPDQVIKGGASIIQCHILNDKRHI 375 Query: 286 VTASSDNLARLWCV 299 +T ++N W V Sbjct: 376 LTKDTNNNVAYWDV 389 Score = 139 bits (350), Expect = 2e-33, Method: Composition-based stats. Identities = 34/242 (14%), Positives = 77/242 (31%), Gaps = 11/242 (4%) Query: 87 NIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIF--QVNAPINCVCLHPNQAELI 144 + ++ ++T G D RIW + +N + L N LI Sbjct: 32 GVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKTLI 91 Query: 145 VGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIG 204 + +W+ + + + + D +A+ ++W++ Sbjct: 92 SASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTA 151 Query: 205 DEVTQLIPKT-KIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSG 263 + T + + + T++ + S ++ ++W + + +L + Sbjct: 152 LTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTD 211 Query: 264 NPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDS 323 N + + D ++ SSD RLW + Y H + V L ND+ Sbjct: 212 N--------VKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDA 263 Query: 324 VL 325 Sbjct: 264 FT 265 Score = 129 bits (323), Expect = 2e-30, Method: Composition-based stats. Identities = 39/273 (14%), Positives = 93/273 (34%), Gaps = 30/273 (10%) Query: 45 VNALEVTPDRSMIAAAGYQHI-RMYDLNSNNPNP-IISYDGVNKNIASVGFHEDGRWMYT 102 VNAL++ P + + AG I R++ +N + +P I S + + + +G+ + + Sbjct: 33 VNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKTLIS 92 Query: 103 GGEDCTARIWDL-RSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDH 161 D T ++W+ + + R + + ++ + I +WD+ T Sbjct: 93 ASSDTTVKVWNAHKGFCMSTLRT--HKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLT 150 Query: 162 ---------NEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIP 212 + + SI S ++ + + + ++ VW+ Sbjct: 151 ALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRT--------CAK 202 Query: 213 KTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGW 272 K+ HT + D T + S+D T ++W + + Sbjct: 203 LMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRV--------HDEG 254 Query: 273 MWGCAFSGDSQYIVTASSDNLARLWCVETGEIK 305 +W + ++ + D + +I+ Sbjct: 255 VWALQVNDAFTHVYSGGRDRKIYCTDLRNPDIR 287 Score = 30.5 bits (67), Expect = 0.94, Method: Composition-based stats. Identities = 9/54 (16%), Positives = 16/54 (29%), Gaps = 3/54 (5%) Query: 270 RGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEI---KREYGGHQKAVVCLAF 320 R + + TA D++ R+W V + H V + Sbjct: 30 RNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVL 83 >5XYI-g nrPDB Length = 335 Score = 157 bits (396), Expect = 8e-39, Method: Composition-based stats. Identities = 45/257 (17%), Positives = 90/257 (35%), Gaps = 19/257 (7%) Query: 72 SNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDL----RSRNLQCQRIFQV 127 S + P ++ G N I S+ + ++ + D +A +W L R+ Sbjct: 20 SAHFAPRATFVGHNAAIESIEIDNEHNYLVSASRDKSALVWKLNRTQEQWATPFTRLIGH 79 Query: 128 NAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAA 187 N ++ V L + + L+ + +WDL T ++L + + P + + Sbjct: 80 NHFVSDVSLSRDASHLLTSSWDSTLRLWDLSTRTTKKLFLGHKKDVLGVTFSPCNRRIIS 139 Query: 188 VNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIW 247 V +WN+ +G+ +L + + + + SP ++A D IW Sbjct: 140 VGRDNQVKIWNI---LGENKAELQCSSWVTSVACAPMADETSP--LVIAVGCWDGKVYIW 194 Query: 248 RTSNF-SLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKR 306 L+ E G F+ D ++++T SD +W E G Sbjct: 195 SIEKEAKLIKEFKAHDGR--------CTSVDFTPDGKWVITGGSDRKVVMWLTENGAKTI 246 Query: 307 EYGGHQKAVVCLAFNDS 323 + V +A + Sbjct: 247 SFTA-PSPVHAVAACPT 262 Score = 150 bits (379), Expect = 7e-37, Method: Composition-based stats. Identities = 45/311 (14%), Positives = 102/311 (32%), Gaps = 30/311 (9%) Query: 7 TVGSDPVILATAGYDHTVRFWQAHS-----GICTRTVQHQDSQVNALEVTPDRSMIAAAG 61 + ++ L +A D + W+ + + + V+ + ++ D S + + Sbjct: 40 EIDNEHNYLVSASRDKSALVWKLNRTQEQWATPFTRLIGHNHFVSDVSLSRDASHLLTSS 99 Query: 62 YQ-HIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQ 120 + +R++DL++ + + G K++ V F R + + G D +IW++ N Sbjct: 100 WDSTLRLWDLSTRTTKKL--FLGHKKDVLGVTFSPCNRRIISVGRDNQVKIWNILGEN-- 155 Query: 121 CQRIFQVNAPINCVCLHP-----NQAELIVGDQSGAIHIWDL-KTDHNEQLIPEPEVSIT 174 + Q ++ + V P + + VG G ++IW + K + + T Sbjct: 156 -KAELQCSSWVTSVACAPMADETSPLVIAVGCWDGKVYIWSIEKEAKLIKEFKAHDGRCT 214 Query: 175 SAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTL 234 S PD ++ S +W G P Sbjct: 215 SVDFTPDGKWVITGGSDRKVVMWLTENGAKTISFTAP---------SPVHAVAACPTQAW 265 Query: 235 LATCSADQTCKIWRTSNFSLMTELSI---KSGNPGESSRGWMWGCAFSGDSQYIVTASSD 291 + + + +W + + G A++ D + + +D Sbjct: 266 ICAATYEG-IAVWDIGAKQQIDLVQPNFKHEGKRNAGRTPDCTCLAWAADGSVLYSGYND 324 Query: 292 NLARLWCVETG 302 R W V++ Sbjct: 325 GSIRAWEVKSA 335 Score = 69.4 bits (168), Expect = 2e-12, Method: Composition-based stats. Identities = 30/168 (17%), Positives = 63/168 (37%), Gaps = 16/168 (9%) Query: 4 SPGTVGSDPVILATAGYDHTVRFWQAHS-GICTRTVQHQDSQVNALEVTPDRSMIAAAGY 62 +P + P+++A +D V W + + D + +++ TPD + G Sbjct: 171 APMADETSPLVIAVGCWDGKVYIWSIEKEAKLIKEFKAHDGRCTSVDFTPDGKWVITGGS 230 Query: 63 Q-HIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDL--RSRNL 119 + M+ + N IS+ + +V W+ + A +WD+ + + Sbjct: 231 DRKVVMWL--TENGAKTISFTA-PSPVHAVAACPTQAWICAATYEGIA-VWDIGAKQQID 286 Query: 120 QCQRIFQVNAPIN--------CVCLHPNQAELIVGDQSGAIHIWDLKT 159 Q F+ N C+ + + L G G+I W++K+ Sbjct: 287 LVQPNFKHEGKRNAGRTPDCTCLAWAADGSVLYSGYNDGSIRAWEVKS 334 >6GMH-W nrPDB Length = 305 Score = 156 bits (395), Expect = 1e-38, Method: Composition-based stats. Identities = 51/250 (20%), Positives = 91/250 (36%), Gaps = 23/250 (9%) Query: 82 DGVNKNIASVGFHEDGRW----MYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLH 137 + I SV + + + + TG D ++W R L Q + + + V + Sbjct: 13 QAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGH-QLGVVSVD 71 Query: 138 PNQAELI--VGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCY 195 + I I +WDL+ + I V + PD+ Y+A G Sbjct: 72 ISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVN 131 Query: 196 VWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLM 255 ++ + G + + ++ L +SPD LA+ + D I+ + L+ Sbjct: 132 IFGVESGK--------KEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLL 183 Query: 256 TELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAV 315 L E + FS DSQ +VTAS D +++ V+ + GH V Sbjct: 184 HTL--------EGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWV 235 Query: 316 VCLAFNDSVL 325 + +AF Sbjct: 236 LNVAFCPDDT 245 Score = 145 bits (365), Expect = 3e-35, Method: Composition-based stats. Identities = 60/297 (20%), Positives = 106/297 (35%), Gaps = 22/297 (7%) Query: 30 HSGICTRTVQHQDSQVNALEVTPDR----SMIAAAGYQH-IRMYDLNSNNPNPIISYDGV 84 GI + Q D + ++ ++ + ++++ + S +G Sbjct: 4 QYGILFKQEQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGH 63 Query: 85 NKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELI 144 + SV + D R+WDL + Q + I + P+ L Sbjct: 64 QLGVVSVDISHTLPIAASSSLDAHIRLWDLENGK-QIKSIDAGPVDAWTLAFSPDSQYLA 122 Query: 145 VGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIG 204 G G ++I+ +++ E + I S PD Y+A+ G ++++ G Sbjct: 123 TGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKL 182 Query: 205 DEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGN 264 + H FSPDS LL T S D KI+ + +L LS Sbjct: 183 LH--------TLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLS----- 229 Query: 265 PGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFN 321 W+ AF D + V++SSD ++W V T + HQ V + +N Sbjct: 230 ---GHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYN 283 Score = 143 bits (361), Expect = 7e-35, Method: Composition-based stats. Identities = 50/292 (17%), Positives = 109/292 (37%), Gaps = 22/292 (7%) Query: 11 DPVILATAGYDHTVRFWQAHSGICTR--TVQHQDSQVNALEVTPDRSMIAAAGYQ-HIRM 67 + + T D V+ W+ +++ V +++++ + A++ HIR+ Sbjct: 31 NSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRL 90 Query: 68 YDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQV 127 +DL + I S D + ++ F D +++ TG I+ + S + + Sbjct: 91 WDLENGK--QIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRG 148 Query: 128 NAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAA 187 I + P+ L G G I+I+D+ T + + I S PD+ + Sbjct: 149 K-FILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVT 207 Query: 188 VNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIW 247 + G ++++ + H + L F PD T + S+D++ K+W Sbjct: 208 ASDDGYIKIYDVQHANLA--------GTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVW 259 Query: 248 RTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCV 299 + + + +WG ++G+ IV+ D ++ Sbjct: 260 DVGTRTCVHTF--------FDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYDC 303 Score = 111 bits (276), Expect = 6e-25, Method: Composition-based stats. Identities = 30/193 (15%), Positives = 75/193 (38%), Gaps = 4/193 (2%) Query: 9 GSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAG-YQHIRM 67 D LAT + V + SG ++ + + ++ +PD +A+ I + Sbjct: 115 SPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINI 174 Query: 68 YDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQV 127 +D+ + + +G I S+ F D + + T +D +I+D++ NL + Sbjct: 175 FDIATGKLLH--TLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANL-AGTLSGH 231 Query: 128 NAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAA 187 + + V P+ + ++ +WD+ T + + + + + S + + Sbjct: 232 ASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVS 291 Query: 188 VNSTGNCYVWNLT 200 V ++++ Sbjct: 292 VGDDQEIHIYDCP 304 >6N9G-C nrPDB Length = 353 Score = 153 bits (387), Expect = 8e-38, Method: Composition-based stats. Identities = 54/296 (18%), Positives = 90/296 (30%), Gaps = 22/296 (7%) Query: 9 GSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAG-YQHIRM 67 D + ++ D V W + + V + V A P IA G + Sbjct: 72 CKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSV 131 Query: 68 ----YDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQR 123 +D N N S +++ F + T D T +WD+ S L Q Sbjct: 132 YPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQL-LQS 190 Query: 124 IFQVNAPINCVCLHPN--QAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPD 181 A + C+ L P+ + G +WD+++ Q E + S P Sbjct: 191 FHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDVNSVRYYPS 250 Query: 182 ASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSAD 241 A+ + C +++L + A FS LL D Sbjct: 251 GDAFASGSDDATCRLYDLRADREVAIYSKESIIF------GASSVDFSLSGRLLFAGYND 304 Query: 242 QTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLW 297 T +W S ++ L + S D + S D+ R+W Sbjct: 305 YTINVWDVLKGSRVSIL--------FGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352 Score = 137 bits (346), Expect = 5e-33, Method: Composition-based stats. Identities = 42/302 (13%), Positives = 96/302 (31%), Gaps = 24/302 (7%) Query: 33 ICTRTVQHQDSQVNALEVTPDRSMIAAAGYQ-HIRMYDLNSNNPNPIISYDGVNKNIASV 91 RT++ ++V ++ D+ I ++ + ++D + N ++ + + Sbjct: 54 KTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMP--CTWVMAC 111 Query: 92 GFHEDGRWMYTGGEDCTARIWDL-----RSRNLQCQRIFQVNAPINCVCLHPNQAELIVG 146 + G + GG D ++ L + + + + ++ + +++ Sbjct: 112 AYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTA 171 Query: 147 DQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPD--ASYMAAVNSTGNCYVWNLTGGIG 204 G +WD+++ Q + + P + + VW++ G Sbjct: 172 SGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSG-- 229 Query: 205 DEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGN 264 H R+ P A+ S D TC+++ + S +S Sbjct: 230 ------QCVQAFETHESDVNSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESII 283 Query: 265 PGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDSV 324 G S FS + + +D +W V G GH+ V L + Sbjct: 284 FGAS------SVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDG 337 Query: 325 LG 326 Sbjct: 338 TA 339 Score = 137 bits (346), Expect = 5e-33, Method: Composition-based stats. Identities = 33/156 (21%), Positives = 64/156 (41%), Gaps = 5/156 (3%) Query: 1 MNTSPGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAA 60 ++ +P G+ + G D W SG C + + +S VN++ P A+ Sbjct: 201 LDLAPSETGNT---FVSGGCDKKAMVWDMRSGQCVQAFETHESDVNSVRYYPSGDAFASG 257 Query: 61 GYQ-HIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNL 119 R+YDL ++ I S + + +SV F GR ++ G D T +WD+ + Sbjct: 258 SDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGS- 316 Query: 120 QCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIW 155 + +F ++ + + P+ G + +W Sbjct: 317 RVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352 Score = 129 bits (324), Expect = 1e-30, Method: Composition-based stats. Identities = 41/215 (19%), Positives = 78/215 (36%), Gaps = 9/215 (4%) Query: 110 RIWDLRSRNLQCQRIFQVNAP-INCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPE 168 R+ L ++ +R + + + C+ ++ ++ Q G + +WD T + E + Sbjct: 44 RVEALGQFVMKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTM 103 Query: 169 PEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRF 228 P + + P +A C V+ LT K + HT Y C F Sbjct: 104 PCTWVMACAYAPSGCAIACGGLDNKCSVYPLT--FDKNENMAAKKKSVAMHTNYLSACSF 161 Query: 229 SPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTA 288 + + T S D TC +W + L+ G + A S V+ Sbjct: 162 TNSDMQILTASGDGTCALWDVESGQLLQSF------HGHGADVLCLDLAPSETGNTFVSG 215 Query: 289 SSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDS 323 D A +W + +G+ + + H+ V + + S Sbjct: 216 GCDKKAMVWDMRSGQCVQAFETHESDVNSVRYYPS 250 >4LG8-A nrPDB Length = 354 Score = 152 bits (385), Expect = 1e-37, Method: Composition-based stats. Identities = 51/293 (17%), Positives = 102/293 (34%), Gaps = 21/293 (7%) Query: 9 GSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQ-HIRM 67 SD + T G D V + S T++ +V ++ P + ++ +A IR+ Sbjct: 81 PSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRI 140 Query: 68 YDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQV 127 + + + + ++ + + H G ++ + +D D+++ + + + Sbjct: 141 WSVPNASCVQVV--RAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDET 198 Query: 128 NA-PINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMA 186 + + C HP+ G I IWDLK N P ITS + Y+A Sbjct: 199 SGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLA 258 Query: 187 AVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKI 246 + +W+L + QL + F T LA D I Sbjct: 259 TAADDSSVKLWDLRKLKNFKTLQL-------DNNFEVKSLIFDQSGTYLALGGTDVQIYI 311 Query: 247 WRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCV 299 ++ + + SG G AF +++I + D + + + Sbjct: 312 --CKQWTEILHFTEHSGLTT--------GVAFGHHAKFIASTGMDRSLKFYSL 354 Score = 139 bits (349), Expect = 2e-33, Method: Composition-based stats. Identities = 44/272 (16%), Positives = 86/272 (31%), Gaps = 21/272 (7%) Query: 51 TPDRSMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTAR 110 D + I G + + ++ + + G K + SV FH +++ D T R Sbjct: 81 PSDTNKILTGGADK-NVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIR 139 Query: 111 IWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPE 170 IW + + + Q + + + + LH L+ D++T + + Sbjct: 140 IWSVPNASC-VQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDET 198 Query: 171 V--SITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRF 228 S+T A PD +W+L P H+ F Sbjct: 199 SGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTN--------VANFPGHSGPITSIAF 250 Query: 229 SPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTA 288 S + LAT + D + K+W L + + + F Y+ Sbjct: 251 SENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFE-------VKSLIFDQSGTYLALG 303 Query: 289 SSDNLARLWCVETGEIKREYGGHQKAVVCLAF 320 +D +++ + + H +AF Sbjct: 304 GTD--VQIYICKQWTEILHFTEHSGLTTGVAF 333 Score = 102 bits (254), Expect = 2e-22, Method: Composition-based stats. Identities = 26/192 (13%), Positives = 64/192 (33%), Gaps = 15/192 (7%) Query: 131 INCVCLHPNQAE-LIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVN 189 I + L P+ ++ G + ++D ++ + +TS P + + + Sbjct: 74 ILALDLCPSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSAS 133 Query: 190 STGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRT 249 +W++ +V + AH L + S DQ Sbjct: 134 PDATIRIWSVPNASCVQV--------VRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDI 185 Query: 250 SNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYG 309 ++T+++ ++ + F D T + D+ ++W ++ + Sbjct: 186 QTGRVLTKVTDETSGCS------LTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFP 239 Query: 310 GHQKAVVCLAFN 321 GH + +AF+ Sbjct: 240 GHSGPITSIAFS 251 Score = 74.8 bits (182), Expect = 4e-14, Method: Composition-based stats. Identities = 20/153 (13%), Positives = 50/153 (32%), Gaps = 5/153 (3%) Query: 6 GTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQ-H 64 D +I T D ++ W + ++ + + +A A Sbjct: 206 AQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSS 265 Query: 65 IRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRI 124 ++++DL + D N + S+ F + G ++ GG D +I+ + + Sbjct: 266 VKLWDLRKLKNFKTLQLD-NNFEVKSLIFDQSGTYLALGGTD--VQIYICKQWT-EILHF 321 Query: 125 FQVNAPINCVCLHPNQAELIVGDQSGAIHIWDL 157 + + V + + ++ + L Sbjct: 322 TEHSGLTTGVAFGHHAKFIASTGMDRSLKFYSL 354 Score = 64.0 bits (154), Expect = 8e-11, Method: Composition-based stats. Identities = 19/103 (18%), Positives = 37/103 (35%), Gaps = 9/103 (8%) Query: 222 YALQCRFSP-DSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSG 280 L P D+ + T AD+ ++ S+ ++ L + + F Sbjct: 73 GILALDLCPSDTNKILTGGADKNVVVFDKSSEQILATLKGHT--------KKVTSVVFHP 124 Query: 281 DSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDS 323 + +AS D R+W V + H+ AV L+ + + Sbjct: 125 SQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHAT 167 Score = 47.5 bits (111), Expect = 8e-06, Method: Composition-based stats. Identities = 14/65 (21%), Positives = 25/65 (38%) Query: 259 SIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCL 318 + G S G + D+ I+T +D ++ + +I GH K V + Sbjct: 61 ASHVGLHSASIPGILALDLCPSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSV 120 Query: 319 AFNDS 323 F+ S Sbjct: 121 VFHPS 125 >5WLC-LO nrPDB Length = 923 Score = 152 bits (383), Expect = 2e-37, Method: Composition-based stats. Identities = 51/313 (16%), Positives = 106/313 (33%), Gaps = 22/313 (7%) Query: 12 PVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLN 71 +LA R + + + + VN + V +A + ++ Sbjct: 272 TRLLAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVSVNQTGEWLAFGSSKLGQLLVYE 331 Query: 72 SNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIF-QVNAP 130 + + I+ G + S+ + DG + T ED ++WD+ S C F + + Sbjct: 332 WQSESYILKQQGHFDSTNSLAYSPDGSRVVTASEDGKIKVWDITSG--FCLATFEEHTSS 389 Query: 131 INCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPE-PEVSITSAHIDPDASYMAAVN 189 + V + G + WDL N + + +DP + A + Sbjct: 390 VTAVQFAKRGQVMFSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVDPSGEVVCAGS 449 Query: 190 STG-NCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWR 248 + +VW++ G + H FS ++++LA+ S D+T +IW Sbjct: 450 LDNFDIHVWSVQTG--------QLLDALSGHEGPVSCLSFSQENSVLASASWDKTIRIWS 501 Query: 249 TSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREY 308 S E P E + + D + + ++ ++ +E + Sbjct: 502 IFGRSQQVE-------PIEVYSD-VLALSMRPDGKEVAVSTLKGQISIFNIEDAKQVGNI 553 Query: 309 GGHQKAVVCLAFN 321 +K ++ FN Sbjct: 554 DC-RKDIISGRFN 565 Score = 150 bits (379), Expect = 6e-37, Method: Composition-based stats. Identities = 52/366 (14%), Positives = 98/366 (26%), Gaps = 89/366 (24%) Query: 7 TVGSDPVILATAGYDHTVRFWQAHSGI---CTRTVQHQDSQVNALEVTPDRSMIAAAGYQ 63 T D + T D + + W S T V + D+ I Sbjct: 153 TWSQDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGAFFSHDQEKIYTVSKD 212 Query: 64 -HIRMYDLNSN--------------NPNPIIS-----------YDGVNKNIASVGFHEDG 97 + +++ IS + + V FH Sbjct: 213 GAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQAKVKCVTFHPAT 272 Query: 98 RWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLH-------------------- 137 R + G R++DL L Q++ P+N V ++ Sbjct: 273 RLLAVGFTSGEFRLYDLPDFTL-IQQLSMGQNPVNTVSVNQTGEWLAFGSSKLGQLLVYE 331 Query: 138 -----------------------PNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSIT 174 P+ + ++ + G I +WD+ + E S+T Sbjct: 332 WQSESYILKQQGHFDSTNSLAYSPDGSRVVTASEDGKIKVWDITSGFCLATFEEHTSSVT 391 Query: 175 SAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTL 234 + M + + G W+L + + P + Sbjct: 392 AVQFAKRGQVMFSSSLDGTVRAWDLIRYRNFRTFTGTERIQFN-------CLAVDPSGEV 444 Query: 235 LATCSADQT-CKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNL 293 + S D +W L+ LS G + +FS ++ + +AS D Sbjct: 445 VCAGSLDNFDIHVWSVQTGQLLDALS--------GHEGPVSCLSFSQENSVLASASWDKT 496 Query: 294 ARLWCV 299 R+W + Sbjct: 497 IRIWSI 502 Score = 142 bits (357), Expect = 3e-34, Method: Composition-based stats. Identities = 39/281 (13%), Positives = 87/281 (30%), Gaps = 16/281 (5%) Query: 9 GSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQ-HIRM 67 D + TA D ++ W SG C T + S V A++ ++ ++ +R Sbjct: 354 SPDGSRVVTASEDGKIKVWDITSGFCLATFEEHTSSVTAVQFAKRGQVMFSSSLDGTVRA 413 Query: 68 YDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDC-TARIWDLRSRNLQCQRIFQ 126 +DL + + + G + G D +W +++ L + Sbjct: 414 WDLIRYRNFRTFTGTERIQF-NCLAVDPSGEVVCAGSLDNFDIHVWSVQTGQL-LDALSG 471 Query: 127 VNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMA 186 P++C+ + L I IW + + E + + + PD +A Sbjct: 472 HEGPVSCLSFSQENSVLASASWDKTIRIWSIFGRSQQVEPIEVYSDVLALSMRPDGKEVA 531 Query: 187 AVNSTGNCYVWNLTGG------------IGDEVTQLIPKTKIPAHTRYALQCRFSPDSTL 234 G ++N+ I Q K +++ +S D Sbjct: 532 VSTLKGQISIFNIEDAKQVGNIDCRKDIISGRFNQDRFTAKNSERSKFFTTIHYSFDGMA 591 Query: 235 LATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWG 275 + + + ++ N L+ + + ++ Sbjct: 592 IVAGGNNNSICLYDVPNEVLLKRFIVSRNMALNGTLEFLNS 632 Score = 141 bits (355), Expect = 5e-34, Method: Composition-based stats. Identities = 59/434 (13%), Positives = 128/434 (29%), Gaps = 110/434 (25%) Query: 2 NTSPGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAG 61 N + + +L + D + + + +A++ +PD + A A Sbjct: 57 NIAAIDLNKQGTLLISIDEDGRAILVNFKARNVLHHF-NFKEKCSAVKFSPDGRLFALAS 115 Query: 62 YQHIRMY---DLNSNNP----NPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIW-- 112 + ++++ D+N + + G ++I S+ + +D R++ T +D +A+IW Sbjct: 116 GRFLQIWKTPDVNKDRQFAPFVRHRVHAGHFQDITSLTWSQDSRFILTTSKDLSAKIWSV 175 Query: 113 DLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTD------------ 160 D +NL + +Q ++ + GA+ +W+ Sbjct: 176 DSEEKNLAATTFNGHRDYVMGAFFSHDQEKIYTVSKDGAVFVWEFTKRPSDDDDNESEDD 235 Query: 161 ---------------HNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGD 205 + + + P +A ++G +++L Sbjct: 236 DKQEEVDISKYSWRITKKHFFYANQAKVKCVTFHPATRLLAVGFTSGEFRLYDLPDFTLI 295 Query: 206 EVTQL-----------------------------------IPKTKIPAHTRYALQCRFSP 230 + + K H +SP Sbjct: 296 QQLSMGQNPVNTVSVNQTGEWLAFGSSKLGQLLVYEWQSESYILKQQGHFDSTNSLAYSP 355 Query: 231 DSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESS--------------------- 269 D + + T S D K+W ++ + + + Sbjct: 356 DGSRVVTASEDGKIKVWDITSGFCLATFEEHTSSVTAVQFAKRGQVMFSSSLDGTVRAWD 415 Query: 270 --------------RGWMWGCAFSGDSQYIVTASSDNL-ARLWCVETGEIKREYGGHQKA 314 R A + + S DN +W V+TG++ GH+ Sbjct: 416 LIRYRNFRTFTGTERIQFNCLAVDPSGEVVCAGSLDNFDIHVWSVQTGQLLDALSGHEGP 475 Query: 315 VVCLAFN--DSVLG 326 V CL+F+ +SVL Sbjct: 476 VSCLSFSQENSVLA 489 Score = 102 bits (253), Expect = 3e-22, Method: Composition-based stats. Identities = 46/304 (15%), Positives = 105/304 (34%), Gaps = 38/304 (12%) Query: 48 LEVTPDRSMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDC 107 + + D + + + ++DL NN + Y+ KNIA++ ++ G + + ED Sbjct: 20 ITFSDDGKQLLSPVGNRVSVFDL-INNKSFTFEYE-HRKNIAAIDLNKQGTLLISIDEDG 77 Query: 108 TARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIW---DLKTDHN-- 162 A + + ++RN+ F+ + V P+ + + IW D+ D Sbjct: 78 RAILVNFKARNVLHHFNFKEKC--SAVKFSPDGRLFALASG-RFLQIWKTPDVNKDRQFA 134 Query: 163 ----EQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPA 218 ++ ITS D+ ++ + + +W++ D + + T Sbjct: 135 PFVRHRVHAGHFQDITSLTWSQDSRFILTTSKDLSAKIWSV-----DSEEKNLAATTFNG 189 Query: 219 HTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSL-------------------MTELS 259 H Y + FS D + T S D +W + Sbjct: 190 HRDYVMGAFFSHDQEKIYTVSKDGAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWR 249 Query: 260 IKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLA 319 I + +++ + F ++ + + RL+ + + ++ Q V ++ Sbjct: 250 ITKKHFFYANQAKVKCVTFHPATRLLAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVS 309 Query: 320 FNDS 323 N + Sbjct: 310 VNQT 313 Score = 46.3 bits (108), Expect = 2e-05, Method: Composition-based stats. Identities = 38/273 (13%), Positives = 88/273 (32%), Gaps = 36/273 (13%) Query: 7 TVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQ-HI 65 + + +LA+A +D T+R W S V AL + PD +A + + I Sbjct: 480 SFSQENSVLASASWDKTIRIWSIFGRSQQVEPIEVYSDVLALSMRPDGKEVAVSTLKGQI 539 Query: 66 RMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIF 125 ++++ I K+I S F++D +T ++ + Sbjct: 540 SIFNIEDAKQVGNIDCR---KDIISGRFNQD---RFTAKNSERSKFF------------- 580 Query: 126 QVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQ--------LIPEPEVSITSAH 177 + + ++ G + +I ++D+ + + + + S Sbjct: 581 ------TTIHYSFDGMAIVAGGNNNSICLYDVPNEVLLKRFIVSRNMALNGTLEFLNSKK 634 Query: 178 IDPDASYMAAVNSTGNCYVWN-LTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLA 236 + S ++ N + + + + T+ +FSP + A Sbjct: 635 MTEAGSLDLIDDAGENSDLEDRIDNSLPGSQRGGDLSTRKMRPEVRVTSVQFSPTANAFA 694 Query: 237 TCSADQTCKIWRTSNFSLMTELSIKSGNPGESS 269 S + I+ T++ L + S+ Sbjct: 695 AASTEGLL-IYSTNDTILFDPFDLDVDVTPHST 726 >5I2T-A nrPDB Length = 742 Score = 149 bits (376), Expect = 2e-36, Method: Composition-based stats. Identities = 51/313 (16%), Positives = 106/313 (33%), Gaps = 22/313 (7%) Query: 12 PVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLN 71 +LA R + + + + VN + V +A + ++ Sbjct: 297 TRLLAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVSVNQTGEWLAFGSSKLGQLLVYE 356 Query: 72 SNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIF-QVNAP 130 + + I+ G + S+ + DG + T ED ++WD+ S C F + + Sbjct: 357 WQSESYILKQQGHFDSTNSLAYSPDGSRVVTASEDGKIKVWDITSG--FCLATFEEHTSS 414 Query: 131 INCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPE-PEVSITSAHIDPDASYMAAVN 189 + V + G + WDL N + + +DP + A + Sbjct: 415 VTAVQFAKRGQVMFSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVDPSGEVVCAGS 474 Query: 190 STG-NCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWR 248 + +VW++ G + H FS ++++LA+ S D+T +IW Sbjct: 475 LDNFDIHVWSVQTG--------QLLDALSGHEGPVSCLSFSQENSVLASASWDKTIRIWS 526 Query: 249 TSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREY 308 S E P E + + D + + ++ ++ +E + Sbjct: 527 IFGRSQQVE-------PIEVYSD-VLALSMRPDGKEVAVSTLKGQISIFNIEDAKQVGNI 578 Query: 309 GGHQKAVVCLAFN 321 +K ++ FN Sbjct: 579 DC-RKDIISGRFN 590 Score = 147 bits (371), Expect = 6e-36, Method: Composition-based stats. Identities = 52/366 (14%), Positives = 98/366 (26%), Gaps = 89/366 (24%) Query: 7 TVGSDPVILATAGYDHTVRFWQAHSGI---CTRTVQHQDSQVNALEVTPDRSMIAAAGYQ 63 T D + T D + + W S T V + D+ I Sbjct: 178 TWSQDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGAFFSHDQEKIYTVSKD 237 Query: 64 -HIRMYDLNSN--------------NPNPIIS-----------YDGVNKNIASVGFHEDG 97 + +++ IS + + V FH Sbjct: 238 GAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQAKVKCVTFHPAT 297 Query: 98 RWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLH-------------------- 137 R + G R++DL L Q++ P+N V ++ Sbjct: 298 RLLAVGFTSGEFRLYDLPDFTL-IQQLSMGQNPVNTVSVNQTGEWLAFGSSKLGQLLVYE 356 Query: 138 -----------------------PNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSIT 174 P+ + ++ + G I +WD+ + E S+T Sbjct: 357 WQSESYILKQQGHFDSTNSLAYSPDGSRVVTASEDGKIKVWDITSGFCLATFEEHTSSVT 416 Query: 175 SAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTL 234 + M + + G W+L + + P + Sbjct: 417 AVQFAKRGQVMFSSSLDGTVRAWDLIRYRNFRTFTGTERIQFN-------CLAVDPSGEV 469 Query: 235 LATCSADQT-CKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNL 293 + S D +W L+ LS G + +FS ++ + +AS D Sbjct: 470 VCAGSLDNFDIHVWSVQTGQLLDALS--------GHEGPVSCLSFSQENSVLASASWDKT 521 Query: 294 ARLWCV 299 R+W + Sbjct: 522 IRIWSI 527 Score = 139 bits (350), Expect = 1e-33, Method: Composition-based stats. Identities = 39/281 (13%), Positives = 87/281 (30%), Gaps = 16/281 (5%) Query: 9 GSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQ-HIRM 67 D + TA D ++ W SG C T + S V A++ ++ ++ +R Sbjct: 379 SPDGSRVVTASEDGKIKVWDITSGFCLATFEEHTSSVTAVQFAKRGQVMFSSSLDGTVRA 438 Query: 68 YDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDC-TARIWDLRSRNLQCQRIFQ 126 +DL + + + G + G D +W +++ L + Sbjct: 439 WDLIRYRNFRTFTGTERIQF-NCLAVDPSGEVVCAGSLDNFDIHVWSVQTGQL-LDALSG 496 Query: 127 VNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMA 186 P++C+ + L I IW + + E + + + PD +A Sbjct: 497 HEGPVSCLSFSQENSVLASASWDKTIRIWSIFGRSQQVEPIEVYSDVLALSMRPDGKEVA 556 Query: 187 AVNSTGNCYVWNLTGG------------IGDEVTQLIPKTKIPAHTRYALQCRFSPDSTL 234 G ++N+ I Q K +++ +S D Sbjct: 557 VSTLKGQISIFNIEDAKQVGNIDCRKDIISGRFNQDRFTAKNSERSKFFTTIHYSFDGMA 616 Query: 235 LATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWG 275 + + + ++ N L+ + + ++ Sbjct: 617 IVAGGNNNSICLYDVPNEVLLKRFIVSRNMALNGTLEFLNS 657 Score = 137 bits (346), Expect = 4e-33, Method: Composition-based stats. Identities = 59/434 (13%), Positives = 128/434 (29%), Gaps = 110/434 (25%) Query: 2 NTSPGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAG 61 N + + +L + D + + + +A++ +PD + A A Sbjct: 82 NIAAIDLNKQGTLLISIDEDGRAILVNFKARNVLHHF-NFKEKCSAVKFSPDGRLFALAS 140 Query: 62 YQHIRMY---DLNSNNP----NPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIW-- 112 + ++++ D+N + + G ++I S+ + +D R++ T +D +A+IW Sbjct: 141 GRFLQIWKTPDVNKDRQFAPFVRHRVHAGHFQDITSLTWSQDSRFILTTSKDLSAKIWSV 200 Query: 113 DLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTD------------ 160 D +NL + +Q ++ + GA+ +W+ Sbjct: 201 DSEEKNLAATTFNGHRDYVMGAFFSHDQEKIYTVSKDGAVFVWEFTKRPSDDDDNESEDD 260 Query: 161 ---------------HNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGD 205 + + + P +A ++G +++L Sbjct: 261 DKQEEVDISKYSWRITKKHFFYANQAKVKCVTFHPATRLLAVGFTSGEFRLYDLPDFTLI 320 Query: 206 EVTQL-----------------------------------IPKTKIPAHTRYALQCRFSP 230 + + K H +SP Sbjct: 321 QQLSMGQNPVNTVSVNQTGEWLAFGSSKLGQLLVYEWQSESYILKQQGHFDSTNSLAYSP 380 Query: 231 DSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESS--------------------- 269 D + + T S D K+W ++ + + + Sbjct: 381 DGSRVVTASEDGKIKVWDITSGFCLATFEEHTSSVTAVQFAKRGQVMFSSSLDGTVRAWD 440 Query: 270 --------------RGWMWGCAFSGDSQYIVTASSDNL-ARLWCVETGEIKREYGGHQKA 314 R A + + S DN +W V+TG++ GH+ Sbjct: 441 LIRYRNFRTFTGTERIQFNCLAVDPSGEVVCAGSLDNFDIHVWSVQTGQLLDALSGHEGP 500 Query: 315 VVCLAFN--DSVLG 326 V CL+F+ +SVL Sbjct: 501 VSCLSFSQENSVLA 514 Score = 99.8 bits (247), Expect = 1e-21, Method: Composition-based stats. Identities = 46/304 (15%), Positives = 105/304 (34%), Gaps = 38/304 (12%) Query: 48 LEVTPDRSMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDC 107 + + D + + + ++DL NN + Y+ KNIA++ ++ G + + ED Sbjct: 45 ITFSDDGKQLLSPVGNRVSVFDL-INNKSFTFEYE-HRKNIAAIDLNKQGTLLISIDEDG 102 Query: 108 TARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIW---DLKTDHN-- 162 A + + ++RN+ F+ + V P+ + + IW D+ D Sbjct: 103 RAILVNFKARNVLHHFNFKEKC--SAVKFSPDGRLFALASG-RFLQIWKTPDVNKDRQFA 159 Query: 163 ----EQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPA 218 ++ ITS D+ ++ + + +W++ D + + T Sbjct: 160 PFVRHRVHAGHFQDITSLTWSQDSRFILTTSKDLSAKIWSV-----DSEEKNLAATTFNG 214 Query: 219 HTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSL-------------------MTELS 259 H Y + FS D + T S D +W + Sbjct: 215 HRDYVMGAFFSHDQEKIYTVSKDGAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWR 274 Query: 260 IKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLA 319 I + +++ + F ++ + + RL+ + + ++ Q V ++ Sbjct: 275 ITKKHFFYANQAKVKCVTFHPATRLLAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVS 334 Query: 320 FNDS 323 N + Sbjct: 335 VNQT 338 Score = 45.1 bits (105), Expect = 5e-05, Method: Composition-based stats. Identities = 34/248 (13%), Positives = 79/248 (31%), Gaps = 35/248 (14%) Query: 7 TVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQ-HI 65 + + +LA+A +D T+R W S V AL + PD +A + + I Sbjct: 505 SFSQENSVLASASWDKTIRIWSIFGRSQQVEPIEVYSDVLALSMRPDGKEVAVSTLKGQI 564 Query: 66 RMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIF 125 ++++ I K+I S F++D +T ++ + Sbjct: 565 SIFNIEDAKQVGNIDCR---KDIISGRFNQD---RFTAKNSERSKFF------------- 605 Query: 126 QVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQ--------LIPEPEVSITSAH 177 + + ++ G + +I ++D+ + + + + S Sbjct: 606 ------TTIHYSFDGMAIVAGGNNNSICLYDVPNEVLLKRFIVSRNMALNGTLEFLNSKK 659 Query: 178 IDPDASYMAAVNSTGNCYVWN-LTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLA 236 + S ++ N + + + + T+ +FSP + A Sbjct: 660 MTEAGSLDLIDDAGENSDLEDRIDNSLPGSQRGGDLSTRKMRPEVRVTSVQFSPTANAFA 719 Query: 237 TCSADQTC 244 S + Sbjct: 720 AASTEGLL 727 >1NR0-A nrPDB Length = 611 Score = 147 bits (371), Expect = 6e-36, Method: Composition-based stats. Identities = 51/283 (18%), Positives = 105/283 (37%), Gaps = 13/283 (4%) Query: 41 QDSQVNALEVTPDRSMIAAAG-YQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRW 99 Q + +P A+ + ++R++D + + + + + + + Sbjct: 58 HSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKR 117 Query: 100 MYTGG--EDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQA-ELIVGDQSGAIHIWD 156 + G + ++ + Q A +N V P++ +I G + I++ Sbjct: 118 IAAVGEGRERFGHVFLFDTGTSNGNLTGQARA-MNSVDFKPSRPFRIISGSDDNTVAIFE 176 Query: 157 LKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKI 216 + E + S +PD S A+ G ++N G V + + Sbjct: 177 GPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNV 236 Query: 217 PAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGC 276 AH+ +SPD T +A+ SAD+T KIW + + + + + + G +W Sbjct: 237 -AHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGT-RIEDQQLGIIW-- 292 Query: 277 AFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLA 319 Q +V+ S++ E G I + GH KA+ L+ Sbjct: 293 ----TKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALS 331 Score = 111 bits (278), Expect = 4e-25, Method: Composition-based stats. Identities = 49/350 (14%), Positives = 117/350 (33%), Gaps = 39/350 (11%) Query: 9 GSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAA-AGYQHIRM 67 S P + + D+TV ++ T V+++ PD S+ A+ G I + Sbjct: 157 PSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVL 216 Query: 68 YDLNSNNPNPIISYDG-----VNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQ 122 Y+ + D + ++ + + DG + + D T +IW++ + ++ Sbjct: 217 YNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKT 276 Query: 123 RIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDA 182 + + + L+ +G I+ + + +Q+ +IT+ D Sbjct: 277 IPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADG 336 Query: 183 SYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPA----HTRYALQCRFSPDSTLLATC 238 + + ++ G+ W+++ GI + V + T I + ++ Sbjct: 337 KTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAG 396 Query: 239 -----------------------SADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWG 275 SAD + + G E + Sbjct: 397 GSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYS----HGKLTEVPISYNSS 452 Query: 276 C-AFSGDSQYIVTASSDNLARLWCVETGEI-KREYGGHQKAVVCLAFNDS 323 C A S D Q++ D+ ++ + + + + H + +AF+++ Sbjct: 453 CVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNN 502 Score = 107 bits (268), Expect = 4e-24, Method: Composition-based stats. Identities = 49/333 (14%), Positives = 107/333 (32%), Gaps = 38/333 (11%) Query: 3 TSPGTVGSDPVILATAGYDHTVRFWQA--HSGICTRTVQHQDSQVNALEVTPDRSMIAAA 60 T+ A+ VR W + I T+ V + + IAA Sbjct: 62 TTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAV 121 Query: 61 GY-----QHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRW-MYTGGEDCTARIWDL 114 G H+ ++D ++N N G + + SV F + + +G +D T I+ Sbjct: 122 GEGRERFGHVFLFDTGTSNGN----LTGQARAMNSVDFKPSRPFRIISGSDDNTVAIF-- 175 Query: 115 RSRNLQCQRIFQVNAP-INCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIP------ 167 + + F + ++ V +P+ + G I +++ + Sbjct: 176 EGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKN 235 Query: 168 -EPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQC 226 S+ PD + +A+ ++ +WN+ ++ + T+I + Sbjct: 236 VAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKT--IPVGTRIEDQQLGIIWT 293 Query: 227 RFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIV 286 + L + SA+ S+ + + S D + + Sbjct: 294 K-----QALVSISANGFINFVNPELGSIDQVRY--------GHNKAITALSSSADGKTLF 340 Query: 287 TASSDNLARLWCVETGEIKREYGG-HQKAVVCL 318 +A ++ W + TG R + H + + Sbjct: 341 SADAEGHINSWDISTGISNRVFPDVHATMITGI 373 Score = 95.2 bits (235), Expect = 3e-20, Method: Composition-based stats. Identities = 50/303 (16%), Positives = 99/303 (32%), Gaps = 34/303 (11%) Query: 7 TVGSDPVILATAGYDHTVRFWQAHSGICTRTV-QHQDSQVNALEVTPDRSMIAAAGYQHI 65 + +D L +A + + W +GI R + + ++ T + + H+ Sbjct: 331 SSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHL 390 Query: 66 RMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIF 125 ++ P D + G + D + + + I+ Sbjct: 391 KVV------PAGGSGVDSSKAVANKLSSQPLGLAV---SADGDIAV----AACYKHIAIY 437 Query: 126 QVN--------APINCVCLHPNQAELIVGDQSGAIHIWDLK-TDHNEQLIPEPEVSITSA 176 +CV L ++ + VG Q +H++ L +E ITS Sbjct: 438 SHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSV 497 Query: 177 HIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLA 236 + +++ A + + +++ T HT +SPD+ LA Sbjct: 498 AFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSW-----TFHTAKVACVSWSPDNVRLA 552 Query: 237 TCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARL 296 T S D + +W N + IK + S +W + IV+A D+ + Sbjct: 553 TGSLDNSVIVWNM-NKPSDHPIIIKGAHAMSSVNSVIWL-----NETTIVSAGQDSNIKF 606 Query: 297 WCV 299 W V Sbjct: 607 WNV 609 Score = 81.0 bits (198), Expect = 6e-16, Method: Composition-based stats. Identities = 40/239 (16%), Positives = 83/239 (34%), Gaps = 41/239 (17%) Query: 111 IWDLRSRNLQCQRIFQVNAPINCVC-LHPNQAELIVGDQSGAIHIWDLKTDHNE--QLIP 167 ++ + +L I+ ++ V P+ GD G + IWD + IP Sbjct: 41 VYTVPVGSLTDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIP 100 Query: 168 EPEVSITSAHIDPDASYMAAVNST----GNCYVWNLTGGIGDEVTQ-------------- 209 + D ++ +AAV G+ ++++ G+ Q Sbjct: 101 VFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRP 160 Query: 210 -------------------LIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTS 250 K+ HT++ R++PD +L A+ D T ++ Sbjct: 161 FRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGV 220 Query: 251 NFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYG 309 + + + G ++G +S D I +AS+D ++W V T ++++ Sbjct: 221 DGTKTGVFE-DDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIP 278 Score = 78.7 bits (192), Expect = 4e-15, Method: Composition-based stats. Identities = 43/336 (12%), Positives = 103/336 (30%), Gaps = 59/336 (17%) Query: 7 TVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVN---ALEVTPDRSMIAAAGYQ 63 T D +A+A D T++ W + +T+ + + T +++++ + Sbjct: 246 TWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTK-QALVSISANG 304 Query: 64 HIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQR 123 I + + + + G NK I ++ DG+ +++ + WD+ + + Sbjct: 305 FINFVNPELGSIDQVR--YGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISN-RV 361 Query: 124 IFQVNAPINCVCLHPNQAELIVGDQSGAIHIW---------------------------- 155 V+A + ++ +L + + Sbjct: 362 FPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSA 421 Query: 156 --DLKTDHNEQLIPEP----------EVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGI 203 D+ + I + + + D ++A +V+ L+G Sbjct: 422 DGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGAS 481 Query: 204 GDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSG 263 EV ++ H FS + L + + +N + Sbjct: 482 VSEVKTIV-------HPAEITSVAFSNNGAFLVATDQSRKVIPYSVANN-----FELAHT 529 Query: 264 NPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCV 299 N + ++S D+ + T S DN +W + Sbjct: 530 NSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNM 565 Score = 73.3 bits (178), Expect = 1e-13, Method: Composition-based stats. Identities = 29/162 (17%), Positives = 65/162 (40%), Gaps = 8/162 (4%) Query: 2 NTSPGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQH--QDSQVNALEVTPDRSMIAA 59 N+S + +D +A G D V ++ SG V+ +++ ++ + + + + A Sbjct: 450 NSSCVALSNDKQFVAVGGQDSKVHVYKL-SGASVSEVKTIVHPAEITSVAFSNNGAFLVA 508 Query: 60 AG-YQHIRMYDLNSNNPNP-IISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSR 117 + + Y + +N S+ +A V + D + TG D + +W++ Sbjct: 509 TDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKP 568 Query: 118 NLQCQRIFQVNA--PINCVCLHPNQAELIVGDQSGAIHIWDL 157 + I +A +N V N+ ++ Q I W++ Sbjct: 569 SDHPIIIKGAHAMSSVNSVIWL-NETTIVSAGQDSNIKFWNV 609 Score = 72.1 bits (175), Expect = 3e-13, Method: Composition-based stats. Identities = 25/161 (15%), Positives = 63/161 (39%), Gaps = 8/161 (4%) Query: 46 NALEVTPDRSMIAAAGYQ-HIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGG 104 + + ++ D+ +A G + +Y L+ + + + + I SV F +G ++ Sbjct: 452 SCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIV-HPAEITSVAFSNNGAFLVATD 510 Query: 105 EDCTARIWDLRSRNLQCQRIFQ---VNAPINCVCLHPNQAELIVGDQSGAIHIWDLK--T 159 + + + + N + A + CV P+ L G ++ +W++ + Sbjct: 511 QSRKVIPYSVAN-NFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPS 569 Query: 160 DHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLT 200 DH + +S ++ I + + + + N WN+ Sbjct: 570 DHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWNVP 610 Score = 56.3 bits (134), Expect = 2e-08, Method: Composition-based stats. Identities = 31/161 (19%), Positives = 57/161 (35%), Gaps = 17/161 (10%) Query: 165 LIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYAL 224 + E T A P Y A+ + GN +W+ T T I KT IP + Sbjct: 54 IYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTT------QTTHILKTTIPVFSGPVK 107 Query: 225 QCRFSPDSTLLATCSA--DQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDS 282 + +S +A ++ ++ + L+ ++ M F Sbjct: 108 DISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQA--------RAMNSVDFKPSR 159 Query: 283 QY-IVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFND 322 + I++ S DN ++ + K +G H K V + +N Sbjct: 160 PFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNP 200 Score = 42.1 bits (97), Expect = 3e-04, Method: Composition-based stats. Identities = 21/133 (15%), Positives = 43/133 (32%), Gaps = 8/133 (6%) Query: 193 NCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNF 252 N T V L H+ + SP A+ +IW T+ Sbjct: 32 KIQYCNGTSVYTVPVGSLTDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQT 91 Query: 253 SLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASS--DNLARLWCVETGEIKREYGG 310 + + + +I + G + ++ +S+ I + ++ +TG G Sbjct: 92 THILKTTIPVFS------GPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTG 145 Query: 311 HQKAVVCLAFNDS 323 +A+ + F S Sbjct: 146 QARAMNSVDFKPS 158 >3ODT-A nrPDB Length = 313 Score = 144 bits (363), Expect = 5e-35, Method: Composition-based stats. Identities = 53/289 (18%), Positives = 107/289 (37%), Gaps = 28/289 (9%) Query: 15 LATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHI--RMYDLNS 72 +A+ D TVR W V +N++ ++ ++ G + + + Sbjct: 32 VASVSRDGTVRLWSKDDQWLGTVVYTGQGFLNSVCYDSEKELLLFGGKDTMINGVPLFAT 91 Query: 73 NNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPIN 132 + +P+ + G N+ S+ F +DG + +G D TA++W S Q Sbjct: 92 SGEDPLYTLIGHQGNVCSLSF-QDG-VVISGSWDKTAKVWKEGSLVYNLQAHNASVWDAK 149 Query: 133 CVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPE-PEVSITSAHIDPDASYMAAVNST 191 V N + + I +W + D + + + D ++ + ++ Sbjct: 150 VVSFSEN--KFLTASADKTIKLW--QNDKVIKTFSGIHNDVVRHLAVVDDGHFI-SCSND 204 Query: 192 GNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSN 251 G + ++ G H + + P+ + +C D+T +IW N Sbjct: 205 GLIKLVDMHTG--------DVLRTYEGHESFVYCIKLLPNGD-IVSCGEDRTVRIWSKEN 255 Query: 252 FSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVE 300 SL +++ + + W C +GD I+ SSDNL R++ E Sbjct: 256 GSLKQVITLPAISI------WSVDCMSNGD---IIVGSSDNLVRIFSQE 295 Score = 93.7 bits (231), Expect = 1e-19, Method: Composition-based stats. Identities = 41/225 (18%), Positives = 80/225 (35%), Gaps = 27/225 (12%) Query: 100 MYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIH---IWD 156 + + D T R+W + ++ +N VC + L+ G + I+ ++ Sbjct: 32 VASVSRDGTVRLWS-KDDQWLGTVVYTGQGFLNSVCYDSEKELLLFGGKDTMINGVPLFA 90 Query: 157 LKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKI 216 + + + ++ S D + + + VW + + Sbjct: 91 TSGEDPLYTLIGHQGNVCSLSFQ-DG-VVISGSWDKTAKVW----------KEGSLVYNL 138 Query: 217 PAHTRYALQCRF-SPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWG 275 AH + S T SAD+T K+W+ N ++ S + Sbjct: 139 QAHNASVWDAKVVSFSENKFLTASADKTIKLWQ--NDKVIKTFSG-------IHNDVVRH 189 Query: 276 CAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAF 320 A D +I + S+D L +L + TG++ R Y GH+ V C+ Sbjct: 190 LAVVDDGHFI-SCSNDGLIKLVDMHTGDVLRTYEGHESFVYCIKL 233 Score = 42.1 bits (97), Expect = 3e-04, Method: Composition-based stats. Identities = 9/60 (15%), Positives = 25/60 (41%) Query: 15 LATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLNSNN 74 + + G D TVR W +G + + + +++ + +I + +R++ + Sbjct: 239 IVSCGEDRTVRIWSKENGSLKQVITLPAISIWSVDCMSNGDIIVGSSDNLVRIFSQEKSR 298 Score = 40.5 bits (93), Expect = 9e-04, Method: Composition-based stats. Identities = 18/96 (18%), Positives = 38/96 (39%), Gaps = 11/96 (11%) Query: 233 TLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDN 292 + +A+ S D T ++W + L G + +G++ + + + ++ D Sbjct: 30 SKVASVSRDGTVRLWSKDDQWL--------GTVVYTGQGFLNSVCYDSEKELLLFGGKDT 81 Query: 293 LAR---LWCVETGEIKREYGGHQKAVVCLAFNDSVL 325 + L+ + GHQ V L+F D V+ Sbjct: 82 MINGVPLFATSGEDPLYTLIGHQGNVCSLSFQDGVV 117 >5OQL-d nrPDB Length = 446 Score = 144 bits (362), Expect = 6e-35, Method: Composition-based stats. Identities = 60/295 (20%), Positives = 106/295 (35%), Gaps = 23/295 (7%) Query: 15 LATAGYDHTVRFWQAHSGICTR-TVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLNSN 73 +A+ D V+ W + V ++ V L T D+ +++ A I+++D ++ Sbjct: 82 IASGSGDGVVKVWDLTTRDEETWRVAAHNNIVKGLTFTNDKKLLSCATDG-IKLWDPYAS 140 Query: 74 --NPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLR-SRNLQCQRIFQVNAP 130 N PI ++ S+ FH RIWDL S Q + Sbjct: 141 PSNTTPIATWQ-EGGPYTSLSFHRSANTFAASSGQGCIRIWDLEHSTAGQAIQWPSFVDT 199 Query: 131 INCVCLHPNQAELI-VGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASY-MAAV 188 I VC + + +I +I ++DL+T+ + +P + +A Sbjct: 200 ITDVCFNQVETSVIGSVATDRSIILFDLRTNMPVIKTVLH-FACNRIVFNPMEAMNLAVA 258 Query: 189 NSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWR 248 + N Y+++ Q H + FSP L + S D+T ++WR Sbjct: 259 SEDHNIYIFDARNFDKALNIQ-------KGHVAAVMDVEFSPTGEELVSGSYDRTIRLWR 311 Query: 249 TSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGE 303 K ++ ++ DS+YI+T S D RLW E Sbjct: 312 RDAGHSRDVYHTKRMQR-------VFRTMWTMDSKYILTGSDDGNVRLWRANASE 359 Score = 117 bits (293), Expect = 7e-27, Method: Composition-based stats. Identities = 53/285 (18%), Positives = 98/285 (34%), Gaps = 35/285 (12%) Query: 40 HQDSQVNALEVTPDRSMIAAAGYQH--IRMYDLNSNNPNPIISYDGVNKNIASVGFHEDG 97 V ++ + A+G ++++DL + + N + + F D Sbjct: 64 GHVQGVYSMCKDKNSLNCIASGSGDGVVKVWDLTTRDEETWRV-AAHNNIVKGLTFTNDK 122 Query: 98 RWMYTGGEDCTARIWDLRSRNLQC--QRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIW 155 + + + D ++WD + +Q P + H + G I IW Sbjct: 123 KLL-SCATDG-IKLWDPYASPSNTTPIATWQEGGPYTSLSFHRSANTFAASSGQGCIRIW 180 Query: 156 DLKTDHNEQLIPEPE--VSITSAHIDP-DASYMAAVNSTGNCYVWNLTGGIGDEVTQLIP 212 DL+ Q I P +IT + + S + +V + + +++L + T L Sbjct: 181 DLEHSTAGQAIQWPSFVDTITDVCFNQVETSVIGSVATDRSIILFDLRTNMPVIKTVLHF 240 Query: 213 KTKIPAHTRYALQCRFSP-DSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRG 271 + F+P ++ LA S D I+ NF K+ N + Sbjct: 241 ACN---------RIVFNPMEAMNLAVASEDHNIYIFDARNFD-------KALNIQKGHVA 284 Query: 272 WMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVV 316 + FS + +V+ S D RLW R GH + V Sbjct: 285 AVMDVEFSPTGEELVSGSYDRTIRLW--------RRDAGHSRDVY 321 Score = 88.3 bits (217), Expect = 4e-18, Method: Composition-based stats. Identities = 33/209 (15%), Positives = 66/209 (31%), Gaps = 9/209 (4%) Query: 15 LATAGYDHTVRFWQAHSGICTRTVQ--HQDSQVNALEVTP-DRSMIAA-AGYQHIRMYDL 70 A + +R W + +Q + + + S+I + A + I ++DL Sbjct: 168 FAASSGQGCIRIWDLEHSTAGQAIQWPSFVDTITDVCFNQVETSVIGSVATDRSIILFDL 227 Query: 71 NSNNPNPIISYDGVNKNIASVGFHE-DGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNA 129 +N P + F+ + + ED I+D R+ + A Sbjct: 228 RTNMPVIKTVLH---FACNRIVFNPMEAMNLAVASEDHNIYIFDARNFDKALNIQKGHVA 284 Query: 130 PINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLI-PEPEVSITSAHIDPDASYMAAV 188 + V P EL+ G I +W H+ + + + D+ Y+ Sbjct: 285 AVMDVEFSPTGEELVSGSYDRTIRLWRRDAGHSRDVYHTKRMQRVFRTMWTMDSKYILTG 344 Query: 189 NSTGNCYVWNLTGGIGDEVTQLIPKTKIP 217 + GN +W V + + Sbjct: 345 SDDGNVRLWRANASERSGVKATRQRQALE 373 Score = 78.3 bits (191), Expect = 4e-15, Method: Composition-based stats. Identities = 22/158 (13%), Positives = 55/158 (34%), Gaps = 6/158 (3%) Query: 11 DPVILATAGYDHTVRFWQAHSGICT-RTVQHQDSQVNALEVTP--DRSMIAAAGYQHIRM 67 + ++ + D ++ + + + +TV H N + P ++ A+ +I + Sbjct: 209 ETSVIGSVATDRSIILFDLRTNMPVIKTVLHF--ACNRIVFNPMEAMNLAVASEDHNIYI 266 Query: 68 YDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQV 127 +D N + G + V F G + +G D T R+W + + + + Sbjct: 267 FDAR-NFDKALNIQKGHVAAVMDVEFSPTGEELVSGSYDRTIRLWRRDAGHSRDVYHTKR 325 Query: 128 NAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQL 165 + + ++ G G + +W + Sbjct: 326 MQRVFRTMWTMDSKYILTGSDDGNVRLWRANASERSGV 363 Score = 43.2 bits (100), Expect = 1e-04, Method: Composition-based stats. Identities = 16/75 (21%), Positives = 31/75 (41%), Gaps = 4/75 (5%) Query: 9 GSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDS--QVNALEVTPDRSMIAAAGYQ-HI 65 L + YD T+R W+ +G +R V H +V T D I ++ Sbjct: 292 SPTGEELVSGSYDRTIRLWRRDAGH-SRDVYHTKRMQRVFRTMWTMDSKYILTGSDDGNV 350 Query: 66 RMYDLNSNNPNPIIS 80 R++ N++ + + + Sbjct: 351 RLWRANASERSGVKA 365 >6EOJ-D nrPDB Length = 470 Score = 136 bits (342), Expect = 1e-32, Method: Composition-based stats. Identities = 42/291 (14%), Positives = 102/291 (35%), Gaps = 19/291 (6%) Query: 10 SDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAA-GYQHIRMY 68 + L A Y W A S +Q DS V ++ + D + + I+++ Sbjct: 103 PEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIW 162 Query: 69 DLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVN 128 N + I + ++I + F + T +D +IW+ + Q + + + Sbjct: 163 QPNFSMVKEIDA--AHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGK-QERVLSGHH 219 Query: 129 APINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDP-DASYMAA 187 + HP + + + +WD ++ + I + + ++ P + + A Sbjct: 220 WDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMA 279 Query: 188 VNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLAT-CSADQTCKI 246 ++ +C V+++ + + + + + P + + T D + K Sbjct: 280 ISKDKSCRVFDIRYSMKELMCVR--------DETDYMTLEWHPINESMFTLACYDGSLK- 330 Query: 247 WRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLW 297 +F L+ L+ + + +++ TA+ D R W Sbjct: 331 ----HFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFW 377 Score = 134 bits (336), Expect = 6e-32, Method: Composition-based stats. Identities = 46/220 (20%), Positives = 78/220 (35%), Gaps = 20/220 (9%) Query: 104 GEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNE 163 G D + +V I + P L+V SG +W+ + E Sbjct: 73 GRDRVINL----PSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFE 128 Query: 164 QLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYA 223 L+ + ++T+ D+ +M + ++ G +W + E+ AHT Sbjct: 129 TLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEID--------AAHTESI 180 Query: 224 LQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQ 283 FS + + TCS D KIW SN LS + + C + + Sbjct: 181 RDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWD--------VKSCDWHPEMG 232 Query: 284 YIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDS 323 I +AS DNL +LW +G + V+ F + Sbjct: 233 LIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPT 272 Score = 112 bits (280), Expect = 2e-25, Method: Composition-based stats. Identities = 33/240 (13%), Positives = 78/240 (32%), Gaps = 20/240 (8%) Query: 85 NKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELI 144 I ++ + +GR + +W+ S + ++ + + + +I Sbjct: 93 KHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQ-AHDSAVTTMKYSHDSDWMI 151 Query: 145 VGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIG 204 GD G I IW +++ SI + S + +WN + G Sbjct: 152 SGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQ 211 Query: 205 DEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGN 264 + V + H C + P+ L+A+ S D K+W + + ++ + Sbjct: 212 ERV--------LSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHT 263 Query: 265 PGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVE--TGEIKREYGGHQKAVVCLAFND 322 ++ ++ S D R++ + E+ + + L ++ Sbjct: 264 VLKTRFQP-------TKGNLLMAISKDKSCRVFDIRYSMKELMCVRD--ETDYMTLEWHP 314 Score = 109 bits (272), Expect = 2e-24, Method: Composition-based stats. Identities = 36/231 (15%), Positives = 75/231 (32%), Gaps = 15/231 (6%) Query: 9 GSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQH-IRM 67 S+ T D+ ++ W +G R + V + + P+ +IA+A + +++ Sbjct: 186 SSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKL 245 Query: 68 YDLNSNNPNPIISYDGVNKNIASVGFHED-GRWMYTGGEDCTARIWDLRSRNLQCQRIFQ 126 +D S N I + F G + +D + R++D+R + + + Sbjct: 246 WDPRSGNCISSILKFKHT--VLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCV-R 302 Query: 127 VNAPINCVCLHP-NQAELIVGDQSGAIHIWDLKTDHNEQLIP---EPEVSITSAHIDPDA 182 + HP N++ + G++ +DL + NE ++ + ITS +P Sbjct: 303 DETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVG 362 Query: 183 SYMAAVNSTGNCYVW------NLTGGIGDEVTQLIPKTKIPAHTRYALQCR 227 A W + R Sbjct: 363 HIFATAAKDRTIRFWTRARPIDPNAYDDPTYNNKKINGWFFGINNDINAVR 413 >6BX3-A nrPDB Length = 314 Score = 134 bits (338), Expect = 4e-32, Method: Composition-based stats. Identities = 44/280 (15%), Positives = 94/280 (33%), Gaps = 10/280 (3%) Query: 46 NALEVTPDRSMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGE 105 +++PD +A +I +YD+N + + + + + + DG+ + T + Sbjct: 16 TCAKISPDGQFLAITQGLNILIYDINRRTVSQTLV-TSHARPFSELCWSPDGQCIATASD 74 Query: 106 DCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQL 165 D + I L L AP+ + + L +I IWD + Sbjct: 75 DFSVEIIHLSYGLLHT--FIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKT 132 Query: 166 IPEPEVSITSAHID-PDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYAL 224 I ++ S + D+S +++ + G +++ G + K Sbjct: 133 ISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPIS 192 Query: 225 QCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQY 284 Q +FS ++ L S D KIW ++ ++ G D Sbjct: 193 QVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGST 252 Query: 285 --IVTASSDNLARLWCVETGEIKREYGG----HQKAVVCL 318 +++ + W +T + + G H V+ + Sbjct: 253 PLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSI 292 Score = 123 bits (309), Expect = 9e-29, Method: Composition-based stats. Identities = 47/287 (16%), Positives = 102/287 (35%), Gaps = 23/287 (8%) Query: 24 VRFWQAHSGICTRTVQH-QDSQVNALEVTPDRSMIAAAGYQ-HIRMYDLNSNNPNPIISY 81 + + + ++T+ + L +PD IA A + + L+ + ++ Sbjct: 35 ILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLSYG---LLHTF 91 Query: 82 DGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQA 141 G + S+ F+ G ++T D + +IWD + +L + I + + V + N + Sbjct: 92 IGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLM-KTISAHSEAVVSVDVPMNDS 150 Query: 142 ELI-VGDQSGAIHIWDLKTDHNEQLIPEPEV--------SITSAHIDPDASYMAAVNSTG 192 ++ G G I I+D +T H + + + I+ +A Y+ + G Sbjct: 151 SILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDG 210 Query: 193 NCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDST--LLATCSADQTCKIWRTS 250 +W+ GG Q+ P K H + D + L+ + + W + Sbjct: 211 VVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSD 270 Query: 251 NFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLW 297 SL+ L + + + + + + LW Sbjct: 271 TKSLLQLLDGSLYH----HSSPVMSI--HCFGNIMCSLALNGDCCLW 311 Score = 103 bits (256), Expect = 1e-22, Method: Composition-based stats. Identities = 47/222 (21%), Positives = 93/222 (41%), Gaps = 26/222 (11%) Query: 2 NTSPG---TVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVT-PDRSMI 57 +T+P T +L T+ D +++ W +G +T+ V +++V D S++ Sbjct: 94 HTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSIL 153 Query: 58 AAAGYQH-IRMYDLNSNNPNPIISYDGVNK------NIASVGFHEDGRWMYTGGEDCTAR 110 ++ Y IR++D + + ++YD K I+ V F E+ R++ D + Sbjct: 154 SSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVK 213 Query: 111 IWD------LRSRNLQCQRIFQVNAPINCVCLHPNQ---AELIVGDQSGAIHIWDLKTDH 161 IWD +R+ +Q ++ L+P +I G ++G I+ W+ T Sbjct: 214 IWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKS 273 Query: 162 NEQLIPE----PEVSITSAHIDPDASYMAAVNSTGNCYVWNL 199 QL+ + S H + M ++ G+C +W Sbjct: 274 LLQLLDGSLYHHSSPVMSIHCF--GNIMCSLALNGDCCLWRW 313 Score = 97.1 bits (240), Expect = 9e-21, Method: Composition-based stats. Identities = 45/261 (17%), Positives = 88/261 (33%), Gaps = 32/261 (12%) Query: 9 GSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQH-IRM 67 D +ATA D +V G T + V +L +++ + I++ Sbjct: 63 SPDGQCIATASDDFSVEIIHLSYG-LLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKI 121 Query: 68 YDLNSNNPNPIISYDGVNKNIASVGFH-EDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQ 126 +D + N + + + ++ + SV D + +G D RI+D + C + Sbjct: 122 WD--TLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETG--HCLKTLT 177 Query: 127 VN---------APINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAH 177 + PI+ V N L+V G + IWD + + H Sbjct: 178 YDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLH 237 Query: 178 ID--------PDAS--YMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCR 227 D S + + G+ Y WN + QL+ + H+ + Sbjct: 238 HSCGMDFLNPEDGSTPLVISGYENGDIYCWN---SDTKSLLQLLDGSLYH-HSSPVMSI- 292 Query: 228 FSPDSTLLATCSADQTCKIWR 248 ++ + + + C +WR Sbjct: 293 -HCFGNIMCSLALNGDCCLWR 312 >5WLC-LU nrPDB Length = 489 Score = 131 bits (329), Expect = 5e-31, Method: Composition-based stats. Identities = 57/312 (18%), Positives = 113/312 (36%), Gaps = 48/312 (15%) Query: 15 LATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVT--------PDRS----MIAAAGY 62 LAT D +++W + + + V L VT PD M++ + Sbjct: 83 LATGSADGVIKYWNMSTREEFVSFKAHYGLVTGLCVTQPRFHDKKPDLKSQNFMLSCSDD 142 Query: 63 QHIRMYDLN---------------SNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDC 107 + ++++ +N +N I ++DG + + H + TGG Sbjct: 143 KTVKLWSINVDDYSNKNSSDNDSVTNEEGLIRTFDGESAF-QGIDSHRENSTFATGGA-- 199 Query: 108 TARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQA-ELIVGDQSGAIHIWDLKTDHNEQLI 166 +WD+ +R + I + + N+ L +I ++DL+T+ Q I Sbjct: 200 KIHLWDV-NRLKPVSDLSWGADNITSLKFNQNETDILASTGSDNSIVLYDLRTNSPTQKI 258 Query: 167 PEPEVSITSAHIDPDASY-MAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQ 225 + + +P ++ N N Y +++ H + Sbjct: 259 V-QTMRTNAICWNPMEAFNFVTANEDHNAYYYDMRNLSRS-------LNVFKDHVSAVMD 310 Query: 226 CRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYI 285 FSP + T S D++ +I++T++ K ++ +S DS+YI Sbjct: 311 VDFSPTGDEIVTGSYDKSIRIYKTNHGHSREIYHTKRMQH-------VFQVKYSMDSKYI 363 Query: 286 VTASSDNLARLW 297 ++ S D RLW Sbjct: 364 ISGSDDGNVRLW 375 Score = 112 bits (281), Expect = 2e-25, Method: Composition-based stats. Identities = 39/259 (15%), Positives = 93/259 (35%), Gaps = 33/259 (12%) Query: 15 LATAGYDHTVRFW--QAHSGI---------------CTRTVQHQDSQVNALEVTPDRSMI 57 + + D TV+ W RT +S ++ + S Sbjct: 136 MLSCSDDKTVKLWSINVDDYSNKNSSDNDSVTNEEGLIRTFDG-ESAFQGIDSHRENSTF 194 Query: 58 AAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHE-DGRWMYTGGEDCTARIWDLRS 116 A G I ++D+N P +S+ NI S+ F++ + + + G D + ++DLR+ Sbjct: 195 ATGG-AKIHLWDVNRLKPVSDLSWGA--DNITSLKFNQNETDILASTGSDNSIVLYDLRT 251 Query: 117 RNLQCQRIFQVNAPINCVCLHP-NQAELIVGDQSGAIHIWDLKT-DHNEQLIPEPEVSIT 174 + + N +C +P + ++ + +D++ + + + ++ Sbjct: 252 NSP--TQKIVQTMRTNAICWNPMEAFNFVTANEDHNAYYYDMRNLSRSLNVFKDHVSAVM 309 Query: 175 SAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTL 234 P + + + ++ G E+ ++ Q ++S DS Sbjct: 310 DVDFSPTGDEIVTGSYDKSIRIYKTNHGHSREIYH-------TKRMQHVFQVKYSMDSKY 362 Query: 235 LATCSADQTCKIWRTSNFS 253 + + S D ++WR+ + Sbjct: 363 IISGSDDGNVRLWRSKAWE 381 Score = 97.5 bits (241), Expect = 6e-21, Method: Composition-based stats. Identities = 43/306 (14%), Positives = 93/306 (30%), Gaps = 52/306 (16%) Query: 39 QHQDSQVNALE--VTPDRSMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHE- 95 V A+ + + I+ +++++ +S+ + + + Sbjct: 64 YGHRDGVYAIAKNYGSLNKLATGSADGVIKYWNMSTREE--FVSFKAHYGLVTGLCVTQP 121 Query: 96 ----------DGRWMYTGGEDCTARIW---------------DLRSRNLQCQRIFQVNAP 130 +M + +D T ++W D + R F + Sbjct: 122 RFHDKKPDLKSQNFMLSCSDDKTVKLWSINVDDYSNKNSSDNDSVTNEEGLIRTFDGESA 181 Query: 131 INCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDAS-YMAAVN 189 + H + G IH+WD+ + +ITS + + + +A+ Sbjct: 182 FQGIDSHRENSTFATGG--AKIHLWDVNRLKPVSDLSWGADNITSLKFNQNETDILASTG 239 Query: 190 STGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSP-DSTLLATCSADQTCKIWR 248 S + +++L + +T ++P ++ T + D + Sbjct: 240 SDNSIVLYDLRTNSPTQKIVQTMRTN---------AICWNPMEAFNFVTANEDHNAYYYD 290 Query: 249 TSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREY 308 N S +S N + + FS IVT S D R++ G + Y Sbjct: 291 MRNLS-------RSLNVFKDHVSAVMDVDFSPTGDEIVTGSYDKSIRIYKTNHGHSREIY 343 Query: 309 GGHQKA 314 H K Sbjct: 344 --HTKR 347 Score = 96.8 bits (239), Expect = 1e-20, Method: Composition-based stats. Identities = 35/231 (15%), Positives = 80/231 (34%), Gaps = 9/231 (3%) Query: 10 SDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRS--MIAAAGYQHIRM 67 + AT G + W + + + +L+ + + + + I + Sbjct: 189 RENSTFATGG--AKIHLWDVNRLKPVSDLSWGADNITSLKFNQNETDILASTGSDNSIVL 246 Query: 68 YDLNSNNPNPIISYDGVNKNIASVGFHEDGRW-MYTGGEDCTARIWDLRSRNLQCQRIFQ 126 YDL +N+P I ++ ++ + T ED A +D+R+ + Sbjct: 247 YDLRTNSPTQKIVQ---TMRTNAICWNPMEAFNFVTANEDHNAYYYDMRNLSRSLNVFKD 303 Query: 127 VNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLI-PEPEVSITSAHIDPDASYM 185 + + V P E++ G +I I+ H+ ++ + + D+ Y+ Sbjct: 304 HVSAVMDVDFSPTGDEIVTGSYDKSIRIYKTNHGHSREIYHTKRMQHVFQVKYSMDSKYI 363 Query: 186 AAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLA 236 + + GN +W V K K+ + + R P+ ++ Sbjct: 364 ISGSDDGNVRLWRSKAWERSNVKTTREKNKLEYDEKLKERFRHMPEIKRIS 414 Score = 79.4 bits (194), Expect = 2e-15, Method: Composition-based stats. Identities = 28/154 (18%), Positives = 55/154 (35%), Gaps = 2/154 (1%) Query: 3 TSPGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSM-IAAAG 61 TS ++ ILA+ G D+++ + + T+ + + NA+ P + A Sbjct: 223 TSLKFNQNETDILASTGSDNSIVLYDLRTNSPTQKIVQ-TMRTNAICWNPMEAFNFVTAN 281 Query: 62 YQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQC 121 H Y N + + + V F G + TG D + RI+ + + Sbjct: 282 EDHNAYYYDMRNLSRSLNVFKDHVSAVMDVDFSPTGDEIVTGSYDKSIRIYKTNHGHSRE 341 Query: 122 QRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIW 155 + + V + +I G G + +W Sbjct: 342 IYHTKRMQHVFQVKYSMDSKYIISGSDDGNVRLW 375 Score = 52.1 bits (123), Expect = 4e-07, Method: Composition-based stats. Identities = 26/178 (14%), Positives = 49/178 (27%), Gaps = 30/178 (16%) Query: 168 EPEVSITSAHIDPDA-SYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQC 226 + + + + + +A ++ G WN++ AH Sbjct: 65 GHRDGVYAIAKNYGSLNKLATGSADGVIKYWNMSTR--------EEFVSFKAHYGLVTGL 116 Query: 227 R-----FS---PD---STLLATCSADQTCKIWRT--SNFSLMTELSIKSGNPGES----- 268 F PD + +CS D+T K+W ++S S E Sbjct: 117 CVTQPRFHDKKPDLKSQNFMLSCSDDKTVKLWSINVDDYSNKNSSDNDSVTNEEGLIRTF 176 Query: 269 -SRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDSVL 325 G ++ T + LW V + + + L FN + Sbjct: 177 DGESAFQGIDSHRENSTFATGGA--KIHLWDVNRLKPVSDLSWGADNITSLKFNQNET 232 Score = 40.5 bits (93), Expect = 0.001, Method: Composition-based stats. Identities = 16/70 (22%), Positives = 26/70 (37%), Gaps = 6/70 (8%) Query: 259 SIKSGNPGESSRGWMWGCAFSGDS-QYIVTASSDNLARLWCVETGEIKREYGGHQKAVVC 317 G G R ++ A + S + T S+D + + W + T E + H V Sbjct: 56 KPFVGQLGYGHRDGVYAIAKNYGSLNKLATGSADGVIKYWNMSTREEFVSFKAHYGLVTG 115 Query: 318 LA-----FND 322 L F+D Sbjct: 116 LCVTQPRFHD 125 >4A11-B nrPDB Length = 408 Score = 129 bits (323), Expect = 2e-30, Method: Composition-based stats. Identities = 56/271 (20%), Positives = 99/271 (36%), Gaps = 37/271 (13%) Query: 66 RMYDLNSNNPNPIISYDGVNKNIASVGFHE-DGRWMYTGGEDCTARIWDLRSRNLQCQRI 124 R+ L N + I ++ +GR+M +GG D ++DL + + Q Sbjct: 26 RVLGLELNKDRDVERI--HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYT 83 Query: 125 FQ------------VNAPINCVCLHPNQAELIVGDQ-SGAIHIWDLKTDHNEQLIPEPEV 171 + + V +P+ + + +WD T + E Sbjct: 84 CKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEE- 142 Query: 172 SITSAHIDPDASY--MAAVNSTG-NCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRF 228 ++ S H+ P ++ + AV + G + +L G + Q H + L + Sbjct: 143 TVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQ--------GHRQEILAVSW 194 Query: 229 SPD-STLLATCSADQTCKIWRTSNFS-LMTELSIKSGNPGES-------SRGWMWGCAFS 279 SP +LAT SAD K+W S + L +G ++ G + G F+ Sbjct: 195 SPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFT 254 Query: 280 GDSQYIVTASSDNLARLWCVETGEIKREYGG 310 D +++T +DN RLW GE G Sbjct: 255 SDGLHLLTVGTDNRMRLWNSSNGENTLVNYG 285 Score = 116 bits (289), Expect = 2e-26, Method: Composition-based stats. Identities = 55/306 (17%), Positives = 106/306 (34%), Gaps = 31/306 (10%) Query: 41 QDSQVNALEVTP--DRSMIAAAGYQHIRMYDLNSNNPNPIISYDG-----------VNKN 87 +N L++ P R M++ I +YDL +++ + + Sbjct: 42 HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYS 101 Query: 88 IASVGFHE-DGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQA---EL 143 + +V ++ D + D T ++WD + LQ +F + + P + Sbjct: 102 VETVQWYPHDTGMFTSSSFDKTLKVWD--TNTLQTADVFNFEETVYSHHMSPVSTKHCLV 159 Query: 144 IVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASY-MAAVNSTGNCYVWNLTGG 202 VG + + + DLK+ ++ I + P Y +A ++ +W++ Sbjct: 160 AVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRA 219 Query: 203 IGDEVT--------QLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSL 254 G +T ++ AH F+ D L T D ++W +SN Sbjct: 220 SGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGEN 279 Query: 255 MTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKA 314 K N + + C S + ++ S ++ V +GE GH K Sbjct: 280 TLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGS---TIAVYTVYSGEQITMLKGHYKT 336 Query: 315 VVCLAF 320 V C F Sbjct: 337 VDCCVF 342 Score = 84.0 bits (206), Expect = 8e-17, Method: Composition-based stats. Identities = 44/294 (14%), Positives = 97/294 (32%), Gaps = 37/294 (12%) Query: 11 DPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRS---MIAAAGYQ-HIR 66 D + ++ +D T++ W ++ + + V + ++P + ++A ++ Sbjct: 111 DTGMFTSSSFDKTLKVWDTNTLQTADVF-NFEETVYSHHMSPVSTKHCLVAVGTRGPKVQ 169 Query: 67 MYDLNSNNPNPIISYDGVNKNIASVGFHEDGRW-MYTGGEDCTARIWDLRSRNLQCQRIF 125 + DL S + + I G + I +V + + + T D ++WD+R R C Sbjct: 170 LCDLKSGSCSHI--LQGHRQEILAVSWSPRYDYILATASADSRVKLWDVR-RASGCLITL 226 Query: 126 ----------------QVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEP 169 N +N +C + L+ + +W+ N L+ Sbjct: 227 DQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGEN-TLVNYG 285 Query: 170 EVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIP---AHTRYALQC 226 +V S + + + + G V + +I H + C Sbjct: 286 KVCNNSKK---GLKFTVSCGCSSEFVF--VPYGSTIAVYTVYSGEQITMLKGHYKTVDCC 340 Query: 227 RFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSG 280 F + L + S D W S + + + +S + A+S Sbjct: 341 VFQSNFQELYSGSRDCNILAWVPSLYEPVPD---DDETTTKSQLNPAFEDAWSS 391 Score = 77.5 bits (189), Expect = 8e-15, Method: Composition-based stats. Identities = 32/221 (14%), Positives = 74/221 (33%), Gaps = 32/221 (14%) Query: 2 NTSPGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIA--A 59 + SP V + ++A V+ SG C+ +Q ++ A+ +P I A Sbjct: 148 HMSP--VSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATA 205 Query: 60 AGYQHIRMYDLNSNNPNPIISYD---------------GVNKNIASVGFHEDGRWMYTGG 104 + ++++D+ +I+ D N + + F DG + T G Sbjct: 206 SADSRVKLWDVR-RASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVG 264 Query: 105 EDCTARIWDLRSRNLQCQRIFQV--------NAPINCVCLHPNQAELIVGDQSGAIHIWD 156 D R+W+ + +V ++C C +E + I ++ Sbjct: 265 TDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGC----SSEFVFVPYGSTIAVYT 320 Query: 157 LKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVW 197 + + ++ ++ + + + + N W Sbjct: 321 VYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 361 Score = 67.1 bits (162), Expect = 9e-12, Method: Composition-based stats. Identities = 24/180 (13%), Positives = 59/180 (32%), Gaps = 13/180 (7%) Query: 150 GAIHIWDLKTDHNEQLIPEPEVSITSAHIDP-DASYMAAVNSTGNCYVWNLTGGIGDEVT 208 + L+ + + + I + I+P + YM + S G +++L Sbjct: 23 STRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYY 82 Query: 209 QLIPKTKI-----PAHTRYALQCRFSPDSTLLATCSA-DQTCKIWRTSNFSLMTELSIKS 262 I H ++ P T + T S+ D+T K+W T+ + + Sbjct: 83 TCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEE 142 Query: 263 GNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFND 322 + + +L +++G GH++ ++ ++++ Sbjct: 143 TVYSHHMSPVSTKHC------LVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSP 196 >5G04-R nrPDB Length = 499 Score = 128 bits (322), Expect = 3e-30, Method: Composition-based stats. Identities = 49/287 (17%), Positives = 115/287 (40%), Gaps = 23/287 (8%) Query: 42 DSQVNALEVTPDRSMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMY 101 D +N ++ + +++A A + ++ +S + ++ + + I+SV + ++G ++ Sbjct: 184 DYYLNLVDWS-SGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLA 242 Query: 102 TGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLK-TD 160 G ++WD++ + + + + +A + + N L G +SG IH D++ + Sbjct: 243 VGTSSAEVQLWDVQQQK-RLRNMTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVRVAE 299 Query: 161 HNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHT 220 H+ + + PD ++A+ + VW G G +P H Sbjct: 300 HHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEG----GWVPLQTFTQHQ 355 Query: 221 RYALQCRFSP-DSTLLAT--CSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCA 277 + P S +LAT ++D+ +IW + + ++ + S + Sbjct: 356 GAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ---------VCSIL 406 Query: 278 FSGDSQYIVT--ASSDNLARLWCVETGEIKREYGGHQKAVVCLAFND 322 +S + +++ + N +W T E GH V+ L + Sbjct: 407 WSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSP 453 Score = 127 bits (318), Expect = 7e-30, Method: Composition-based stats. Identities = 41/289 (14%), Positives = 101/289 (34%), Gaps = 33/289 (11%) Query: 21 DHTVRFWQAHSGICTRTVQ--HQDSQVNALEVTPDRSMIAAA-GYQHIRMYDLNSNNPNP 77 D++V W A SG + +Q ++++ + + +A ++++D+ Sbjct: 203 DNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQ--QQKR 260 Query: 78 IISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLH 137 + + + + S+ ++ + +G D+R + + + + Sbjct: 261 LRNMTSHSARVGSLSWNS--YILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWA 318 Query: 138 PNQAELIVGDQSGAIHIWDLKTDH----NEQLIPEPEVSITSAHIDP-DASYMAAVN--S 190 P+ L G +++W Q + + ++ + P ++ +A S Sbjct: 319 PDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTS 378 Query: 191 TGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCS--ADQTCKIWR 248 + +WN+ G + + AH++ +SP L + A IW+ Sbjct: 379 DRHIRIWNVCSGA--------CLSAVDAHSQ-VCSILWSPHYKELISGHGFAQNQLVIWK 429 Query: 249 TSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLW 297 + + EL + + S D + +A++D RLW Sbjct: 430 YPTMAKVAELKGHT--------SRVLSLTMSPDGATVASAAADETLRLW 470 Score = 123 bits (309), Expect = 9e-29, Method: Composition-based stats. Identities = 47/270 (17%), Positives = 95/270 (35%), Gaps = 23/270 (8%) Query: 10 SDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQ--HIRM 67 + LA V+ W R + ++V +L S I ++G + HI Sbjct: 236 KEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWN---SYILSSGSRSGHIHH 292 Query: 68 YDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDL---RSRNLQCQRI 124 +D+ + + G ++ + + + DGR + +GG D +W + Q Sbjct: 293 HDVRVAEH-HVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTF 351 Query: 125 FQVNAPINCVCLHPNQAELIV---GDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPD 181 Q + V P Q+ ++ G I IW++ + + + S P Sbjct: 352 TQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ-VCSILWSPH 410 Query: 182 ASYMAAVN--STGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCS 239 + + + + +W + ++ HT L SPD +A+ + Sbjct: 411 YKELISGHGFAQNQLVIWKYPT--------MAKVAELKGHTSRVLSLTMSPDGATVASAA 462 Query: 240 ADQTCKIWRTSNFSLMTELSIKSGNPGESS 269 AD+T ++WR + + +SS Sbjct: 463 ADETLRLWRCFELDPARRREREKASAAKSS 492 Score = 82.9 bits (203), Expect = 2e-16, Method: Composition-based stats. Identities = 26/157 (16%), Positives = 58/157 (36%), Gaps = 14/157 (8%) Query: 9 GSDPVILATAGYDHTVRFWQAHSG----ICTRTVQHQDSQVNALEVTP-DRSMIAAAG-- 61 D LA+ G D+ V W + G + +T V A+ P +++A G Sbjct: 318 APDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGT 377 Query: 62 -YQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYT--GGEDCTARIWDLRSRN 118 +HIR++++ S + D + S+ + + + + G IW + Sbjct: 378 SDRHIRIWNVCSGACLSAV--DAH-SQVCSILWSPHYKELISGHGFAQNQLVIWKYPT-M 433 Query: 119 LQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIW 155 + + + + + + P+ A + + +W Sbjct: 434 AKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470 Score = 51.7 bits (122), Expect = 4e-07, Method: Composition-based stats. Identities = 20/104 (19%), Positives = 41/104 (39%), Gaps = 8/104 (7%) Query: 222 YALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGD 281 Y +S +LA D + +W S+ ++ L ++ ++ A+ + Sbjct: 186 YLNLVDWS-SGNVLAVA-LDNSVYLWSASSGDILQLLQMEQPG------EYISSVAWIKE 237 Query: 282 SQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDSVL 325 Y+ +S +LW V+ + R H V L++N +L Sbjct: 238 GNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYIL 281 Score = 27.8 bits (60), Expect = 6.8, Method: Composition-based stats. Identities = 8/21 (38%), Positives = 12/21 (57%) Query: 7 TVGSDPVILATAGYDHTVRFW 27 T+ D +A+A D T+R W Sbjct: 450 TMSPDGATVASAAADETLRLW 470 >4AEZ-A nrPDB Length = 401 Score = 128 bits (321), Expect = 4e-30, Method: Composition-based stats. Identities = 55/252 (21%), Positives = 100/252 (39%), Gaps = 17/252 (6%) Query: 11 DPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAG-YQHIRMYD 69 D L+ + V + S RT+ ++V L +R ++++ I +D Sbjct: 145 DGSFLSVGLGNGLVDIYDVESQTKLRTMAGHQARVGCLSW--NRHVLSSGSRSGAIHHHD 202 Query: 70 LNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNA 129 + N I + G + + + + DG + +GG D +IWD RS + + NA Sbjct: 203 VRIANH-QIGTLQGHSSEVCGLAWRSDGLQLASGGNDNVVQIWDARSSIPKFTKTN-HNA 260 Query: 130 PINCVCLHPNQAELIV---GDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMA 186 + V P Q+ L+ G IH W+ T + +TS P + + Sbjct: 261 AVKAVAWCPWQSNLLATGGGTMDKQIHFWNAATGARVNTVDAGSQ-VTSLIWSPHSKEIM 319 Query: 187 AVNS--TGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTC 244 + + N +W+ + + L + IPAH L SPD +L+T ++D+ Sbjct: 320 STHGFPDNNLSIWSYSS------SGLTKQVDIPAHDTRVLYSALSPDGRILSTAASDENL 373 Query: 245 KIWRTSNFSLMT 256 K WR + + Sbjct: 374 KFWRVYDGDHVK 385 Score = 110 bits (274), Expect = 1e-24, Method: Composition-based stats. Identities = 48/300 (16%), Positives = 105/300 (35%), Gaps = 26/300 (8%) Query: 15 LATAGYDHTVRFWQAHSGICTRTVQHQDS-QVNALEVTPDRSMIAAA-GYQHIRMYDLNS 72 + + V W A SG + + +S V +++ + D S ++ G + +YD+ S Sbjct: 106 VVAVALERNVYVWNADSGSVSALAETDESTYVASVKWSHDGSFLSVGLGNGLVDIYDVES 165 Query: 73 NNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPIN 132 ++ G + + ++ + +G D+R N Q + ++ + Sbjct: 166 QTKLRTMA--GHQARVGCLSWNR--HVLSSGSRSGAIHHHDVRIANHQIGTLQGHSSEVC 221 Query: 133 CVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDP-DASYMAAVN-- 189 + + +L G + IWD ++ + ++ + P ++ +A Sbjct: 222 GLAWRSDGLQLASGGNDNVVQIWDARSSIPKFTKTNHNAAVKAVAWCPWQSNLLATGGGT 281 Query: 190 STGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLAT--CSADQTCKIW 247 + WN G + +SP S + + D IW Sbjct: 282 MDKQIHFWNAATG---------ARVNTVDAGSQVTSLIWSPHSKEIMSTHGFPDNNLSIW 332 Query: 248 RTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKRE 307 S+ L ++ I + + + A S D + + TA+SD + W V G+ + Sbjct: 333 SYSSSGLTKQVDIPAHDT------RVLYSALSPDGRILSTAASDENLKFWRVYDGDHVKR 386 Score = 74.4 bits (181), Expect = 6e-14, Method: Composition-based stats. Identities = 29/254 (11%), Positives = 75/254 (29%), Gaps = 25/254 (9%) Query: 74 NPNPIISYDGVNKN--IASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPI 131 P ++ G+ + + + + + + +W+ S ++ + + Sbjct: 80 TPERVLDAPGIIDDYYLNLLDWSNLN--VVAVALERNVYVWNADSGSVSALAETDESTYV 137 Query: 132 NCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNST 191 V + + L VG +G + I+D+++ + + + + + +++ + + Sbjct: 138 ASVKWSHDGSFLSVGLGNGLVDIYDVESQTKLRTMAGHQARVGCL--SWNRHVLSSGSRS 195 Query: 192 GNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSN 251 G D + H+ + D LA+ D +IW + Sbjct: 196 GAI-------HHHDVRIANHQIGTLQGHSSEVCGLAWRSDGLQLASGGNDNVVQIWDARS 248 Query: 252 FSLMTELSIKSGNPGESSRGWMWGCAFSG-DSQYIVTASS--DNLARLWCVETGEIKREY 308 + + + A+ S + T D W TG Sbjct: 249 SIPKFTKT--------NHNAAVKAVAWCPWQSNLLATGGGTMDKQIHFWNAATGARVNTV 300 Query: 309 GGHQKAVVCLAFND 322 V L ++ Sbjct: 301 DA-GSQVTSLIWSP 313 Score = 70.9 bits (172), Expect = 7e-13, Method: Composition-based stats. Identities = 34/176 (19%), Positives = 65/176 (36%), Gaps = 14/176 (7%) Query: 10 SDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTP-DRSMIAAAG---YQHI 65 SD + LA+ G D+ V+ W A S I T + ++ V A+ P +++A G + I Sbjct: 227 SDGLQLASGGNDNVVQIWDARSSIPKFTKTNHNAAVKAVAWCPWQSNLLATGGGTMDKQI 286 Query: 66 RMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYT--GGEDCTARIWDLRSRNL-QCQ 122 ++ + + + S+ + + + + G D IW S L + Sbjct: 287 HFWNAATGARVNTVD---AGSQVTSLIWSPHSKEIMSTHGFPDNNLSIWSYSSSGLTKQV 343 Query: 123 RIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQ----LIPEPEVSIT 174 I + + L P+ L + W + + + + P SIT Sbjct: 344 DIPAHDTRVLYSALSPDGRILSTAASDENLKFWRVYDGDHVKRPIPITKTPSSSIT 399 Score = 45.1 bits (105), Expect = 5e-05, Method: Composition-based stats. Identities = 18/95 (18%), Positives = 37/95 (38%), Gaps = 7/95 (7%) Query: 231 DSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASS 290 + + + ++ +W + S+ S ++ +S D ++ Sbjct: 102 SNLNVVAVALERNVYVWNADSGSV-------SALAETDESTYVASVKWSHDGSFLSVGLG 154 Query: 291 DNLARLWCVETGEIKREYGGHQKAVVCLAFNDSVL 325 + L ++ VE+ R GHQ V CL++N VL Sbjct: 155 NGLVDIYDVESQTKLRTMAGHQARVGCLSWNRHVL 189 >6CHG-D nrPDB Length = 439 Score = 127 bits (319), Expect = 6e-30, Method: Composition-based stats. Identities = 61/323 (18%), Positives = 126/323 (39%), Gaps = 44/323 (13%) Query: 33 ICTRTVQHQDSQVNALEVTPDRSMIAAA-GYQHIRMYDLNSNNPNPII-SYDG-VNKNIA 89 T T++ + V ++ +P +A I +YD++S P ++ ++ G +++ Sbjct: 19 KLTHTLEVPVAAV-CVKFSPRGDYLAVGCSNGAIIIYDMDSLKPIAMLGTHSGAHTRSVQ 77 Query: 90 SVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINC---VCLH--------- 137 SV + DGR++++ G D A++WD+ ++ +C + ++ + P+ V + Sbjct: 78 SVCWSNDGRYLWSSGRDWYAKLWDM-TQPTKCFQQYKFDGPLWSCHVVRWNVCIVTVVEE 136 Query: 138 PNQAELIVGDQSGAIHIWDLK------TDHNEQLIPEPEVSITSAHIDPDASYMAAVNST 191 P L + D+ A H + L + H L+ P +I S I Sbjct: 137 PTAYVLTLTDRQNAFHCFPLLEQDQDISGHGYTLVACPHPTIESIII------TGTSKGW 190 Query: 192 GNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRT-- 249 N + +L G D++ + A Q SP T +A +D+T + ++ Sbjct: 191 INAFQLDLESGFEDKIRCCYEEKIANA---NIKQIIISPSGTRIAINGSDRTIRQYQLIV 247 Query: 250 -SNFSLMTELSIKSGNPGESSRGWMWGCAFSG------DSQYIVT---ASSDNLARLWCV 299 N S S + + ++ +Y+V SS + LW Sbjct: 248 EDNESEGGSSHSVSIELEHKYQDIINRLQWNTIFFSNHSGEYLVASAHGSSAHDLYLWET 307 Query: 300 ETGEIKREYGGHQKAVVCLAFND 322 +G + R G + ++ + +N Sbjct: 308 SSGSLVRVLEGADEELLDIDWNF 330 Score = 60.9 bits (146), Expect = 6e-10, Method: Composition-based stats. Identities = 29/192 (15%), Positives = 60/192 (31%), Gaps = 14/192 (7%) Query: 114 LRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPE--- 170 L+ + +V CV P L VG +GAI I+D+ + ++ Sbjct: 13 LKEYPEKLTHTLEVPVAAVCVKFSPRGDYLAVGCSNGAIIIYDMDSLKPIAMLGTHSGAH 72 Query: 171 -VSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFS 229 S+ S D Y+ + +W++T + T+ + K C Sbjct: 73 TRSVQSVCWSNDGRYLWSSGRDWYAKLWDMT-----QPTKCFQQYKFDG---PLWSCHVV 124 Query: 230 PDSTLLATCSADQTCKIWRTSNFSL-MTELSIKSGNPGESSRGWMWGCAFSGD-SQYIVT 287 + + T + T + ++ + + S G+ I+T Sbjct: 125 RWNVCIVTVVEEPTAYVLTLTDRQNAFHCFPLLEQDQDISGHGYTLVACPHPTIESIIIT 184 Query: 288 ASSDNLARLWCV 299 +S + + Sbjct: 185 GTSKGWINAFQL 196 Score = 39.4 bits (90), Expect = 0.002, Method: Composition-based stats. Identities = 38/312 (12%), Positives = 93/312 (29%), Gaps = 64/312 (20%) Query: 9 GSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMY 68 +D L ++G D + W T+ Q + D + + H+ + Sbjct: 82 SNDGRYLWSSGRDWYAKLWDMT--QPTKCFQ---------QYKFDGPLWSC----HVVRW 126 Query: 69 DLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVN 128 ++ + + + ++ ++ + L+ + + Sbjct: 127 NV-----CIVTVVEEPTAYVLTLTDRQNAFHCF---------------PLLEQDQDISGH 166 Query: 129 APINCVCLHPN-QAELIVGDQSGAIHIW--DLKTDHNEQLIPEPE-----VSITSAHIDP 180 C HP ++ +I G G I+ + DL++ +++ E +I I P Sbjct: 167 GYTLVACPHPTIESIIITGTSKGWINAFQLDLESGFEDKIRCCYEEKIANANIKQIIISP 226 Query: 181 DASYMAAVNSTGNCYVWNL---TGGIGDEVTQLIPKTKIPAHTRYALQCRFSP------D 231 + +A S + L + + + + +++ Sbjct: 227 SGTRIAINGSDRTIRQYQLIVEDNESEGGSSHSVSIELEHKYQDIINRLQWNTIFFSNHS 286 Query: 232 STLLAT---CSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVT- 287 L S+ +W TS+ SL+ L E + + ++ S I + Sbjct: 287 GEYLVASAHGSSAHDLYLWETSSGSLVRVL--------EGADEELLDIDWNFYSMRIASN 338 Query: 288 ASSDNLARLWCV 299 +W + Sbjct: 339 GFESGWVYMWSI 350 >4YCZ-A nrPDB Length = 876 Score = 127 bits (318), Expect = 8e-30, Method: Composition-based stats. Identities = 42/266 (15%), Positives = 84/266 (31%), Gaps = 37/266 (13%) Query: 15 LATAGYDHTVRFWQAH--SGICTRTVQHQDSQVNALEV--TPDRSMIAAAGYQ-HIRMYD 69 LAT D T++ ++ + T T++ D V + +++A+AGY + ++ Sbjct: 33 LATCSSDRTIKIFEIEGETQRLTETLKGHDGAVWCVSWAHPKYGNILASAGYDGKVLIWR 92 Query: 70 LNSNNPNPIISYDGVNKNIASVGF--HEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQV 127 + I + ++ V + HE G + D + + R + + Sbjct: 93 ELNGAWQRIFDFALHKASVNVVSWSPHEAGCLLACASSDGNVSVLEFRDNSWEHSIFHAH 152 Query: 128 NAPINCVCLHPN-----------------QAELIVGDQSGAIHIW--DLKTDH---NEQL 165 +N V P + G A+ IW D T+ + Sbjct: 153 GLGVNSVSWAPATSPGSIVSSKPGPKSTGNRRFVTGGSDNALKIWAYDPATNTYKLEREP 212 Query: 166 IPEPEVSITSAHIDPD---ASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRY 222 + + P SY+A+ + +W D L K+ Sbjct: 213 LTGHTDWVRDVAWSPTVLQKSYIASASEDRTVRIW-----TSDPANPLQWNCKVLNFDAA 267 Query: 223 ALQCRFSPDSTLLATCSADQTCKIWR 248 + +S +LA D +W+ Sbjct: 268 VWRVSWSLSGNVLAASGGDNKVTLWK 293 Score = 126 bits (316), Expect = 1e-29, Method: Composition-based stats. Identities = 39/285 (13%), Positives = 87/285 (30%), Gaps = 35/285 (12%) Query: 40 HQDSQVNALEVTPDRSMIAA-AGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHED-- 96 D ++ + +A + + I+++++ + G + + V + Sbjct: 16 GHDDMIHDAVLDYYGRRLATCSSDRTIKIFEIEGETQRLTETLKGHDGAVWCVSWAHPKY 75 Query: 97 GRWMYTGGEDCTARIWDLRSRNLQCQRIFQ-VNAPINCVCLHPN--QAELIVGDQSGAIH 153 G + + G D IW + Q F A +N V P+ L G + Sbjct: 76 GNILASAGYDGKVLIWRELNGAWQRIFDFALHKASVNVVSWSPHEAGCLLACASSDGNVS 135 Query: 154 IWDLKTDHNEQ-LIPEPEVSITSAHIDP-----------------DASYMAAVNSTGNCY 195 + + + + E + + + S P S Sbjct: 136 VLEFRDNSWEHSIFHAHGLGVNSVSWAPATSPGSIVSSKPGPKSTGNRRFVTGGSDNALK 195 Query: 196 VWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSP---DSTLLATCSADQTCKIWRTSNF 252 +W + + + HT + +SP + +A+ S D+T +IW + Sbjct: 196 IWAYDPATNTY---KLEREPLTGHTDWVRDVAWSPTVLQKSYIASASEDRTVRIWTSDPA 252 Query: 253 SLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLW 297 + + + +W ++S + + DN LW Sbjct: 253 NPLQ-----WNCKVLNFDAAVWRVSWSLSGNVLAASGGDNKVTLW 292 Score = 118 bits (296), Expect = 3e-27, Method: Composition-based stats. Identities = 44/249 (17%), Positives = 77/249 (30%), Gaps = 37/249 (14%) Query: 76 NPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQ-VNAPINCV 134 +I+ G + I GR + T D T +I+++ + + + + CV Sbjct: 9 TQVIANSGHDDMIHDAVLDYYGRRLATCSSDRTIKIFEIEGETQRLTETLKGHDGAVWCV 68 Query: 135 CL-HPN-QAELIVGDQSGAIHIWDLKTDHNEQLIPE--PEVSITSAHIDP--DASYMAAV 188 HP L G + IW +++ + S+ P +A Sbjct: 69 SWAHPKYGNILASAGYDGKVLIWRELNGAWQRIFDFALHKASVNVVSWSPHEAGCLLACA 128 Query: 189 NSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPD----------------- 231 +S GN V + + AH ++P Sbjct: 129 SSDGNVSVLEFRDNSWEH-------SIFHAHGLGVNSVSWAPATSPGSIVSSKPGPKSTG 181 Query: 232 STLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGD---SQYIVTA 288 + T +D KIW + +L + P W+ A+S YI +A Sbjct: 182 NRRFVTGGSDNALKIWAYDPATNTYKLERE---PLTGHTDWVRDVAWSPTVLQKSYIASA 238 Query: 289 SSDNLARLW 297 S D R+W Sbjct: 239 SEDRTVRIW 247 Score = 97.5 bits (241), Expect = 8e-21, Method: Composition-based stats. Identities = 36/218 (16%), Positives = 71/218 (32%), Gaps = 33/218 (15%) Query: 12 PVILATAGYDHTVRFWQAHSGICTR--TVQHQDSQVNALEVTP---DRSMIAAAGYQHIR 66 ILA+AGYD V W+ +G R + VN + +P + A+ ++ Sbjct: 76 GNILASAGYDGKVLIWRELNGAWQRIFDFALHKASVNVVSWSPHEAGCLLACASSDGNVS 135 Query: 67 MYDLNSNNPNPIISYDGVNKNIASVGFHED-----------------GRWMYTGGEDCTA 109 + + N+ I + + SV + R TGG D Sbjct: 136 VLEFRDNSWEHSI-FHAHGLGVNSVSWAPATSPGSIVSSKPGPKSTGNRRFVTGGSDNAL 194 Query: 110 RIW--DLRSRNLQCQR--IFQVNAPINCVCLHPN---QAELIVGDQSGAIHIWDLKTDHN 162 +IW D + + +R + + V P ++ + + + IW + Sbjct: 195 KIWAYDPATNTYKLEREPLTGHTDWVRDVAWSPTVLQKSYIASASEDRTVRIWTSDPANP 254 Query: 163 EQ---LIPEPEVSITSAHIDPDASYMAAVNSTGNCYVW 197 Q + + ++ + +AA +W Sbjct: 255 LQWNCKVLNFDAAVWRVSWSLSGNVLAASGGDNKVTLW 292 Score = 94.4 bits (233), Expect = 5e-20, Method: Composition-based stats. Identities = 37/230 (16%), Positives = 71/230 (30%), Gaps = 29/230 (12%) Query: 118 NLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLK--TDHNEQLIPEPEVSITS 175 Q + I+ L L I I++++ T + + + ++ Sbjct: 8 GTQVIANSGHDDMIHDAVLDYYGRRLATCSSDRTIKIFEIEGETQRLTETLKGHDGAVWC 67 Query: 176 AHI-DPD-ASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPD-- 231 P + +A+ G +W G + H +SP Sbjct: 68 VSWAHPKYGNILASAGYDGKVLIWRELNGAWQRIF------DFALHKASVNVVSWSPHEA 121 Query: 232 STLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAF-----------SG 280 LLA S+D + + S + + G +S W + S Sbjct: 122 GCLLACASSDGNVSVLEFRDNSWEHSI-FHAHGLGVNSVSWAPATSPGSIVSSKPGPKST 180 Query: 281 DSQYIVTASSDNLARLWCVETGEIKREYG-----GHQKAVVCLAFNDSVL 325 ++ VT SDN ++W + + GH V +A++ +VL Sbjct: 181 GNRRFVTGGSDNALKIWAYDPATNTYKLEREPLTGHTDWVRDVAWSPTVL 230 Score = 63.6 bits (153), Expect = 1e-10, Method: Composition-based stats. Identities = 22/138 (15%), Positives = 47/138 (34%), Gaps = 11/138 (7%) Query: 1 MNTSPGTVGSDPVILATAGYDHTVRFWQAH----SGICTRT-VQHQDSQVNALEVTP--- 52 +++ PG + T G D+ ++ W + R + V + +P Sbjct: 171 VSSKPGPKSTGNRRFVTGGSDNALKIWAYDPATNTYKLEREPLTGHTDWVRDVAWSPTVL 230 Query: 53 DRSMIAAAGYQ-HIRMYDLNSNNPNPII-SYDGVNKNIASVGFHEDGRWMYTGGEDCTAR 110 +S IA+A +R++ + NP + + V + G + G D Sbjct: 231 QKSYIASASEDRTVRIWTSDPANPLQWNCKVLNFDAAVWRVSWSLSGNVLAASGGDNKVT 290 Query: 111 IWDLR-SRNLQCQRIFQV 127 +W +C + + Sbjct: 291 LWKENLKGEWECVKTIEE 308 >4GGA-A nrPDB Length = 420 Score = 126 bits (316), Expect = 1e-29, Method: Composition-based stats. Identities = 49/287 (17%), Positives = 115/287 (40%), Gaps = 23/287 (8%) Query: 42 DSQVNALEVTPDRSMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMY 101 D +N ++ + +++A A + ++ +S + ++ + + I+SV + ++G ++ Sbjct: 105 DYYLNLVDWS-SGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLA 163 Query: 102 TGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLK-TD 160 G ++WD++ + + + + +A + + N L G +SG IH D++ + Sbjct: 164 VGTSSAEVQLWDVQQQK-RLRNMTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVRVAE 220 Query: 161 HNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHT 220 H+ + + PD ++A+ + VW G G +P H Sbjct: 221 HHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEG----GWVPLQTFTQHQ 276 Query: 221 RYALQCRFSP-DSTLLAT--CSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCA 277 + P S +LAT ++D+ +IW + + ++ + S + Sbjct: 277 GAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ---------VCSIL 327 Query: 278 FSGDSQYIVT--ASSDNLARLWCVETGEIKREYGGHQKAVVCLAFND 322 +S + +++ + N +W T E GH V+ L + Sbjct: 328 WSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSP 374 Score = 124 bits (311), Expect = 5e-29, Method: Composition-based stats. Identities = 41/289 (14%), Positives = 101/289 (34%), Gaps = 33/289 (11%) Query: 21 DHTVRFWQAHSGICTRTVQ--HQDSQVNALEVTPDRSMIAAA-GYQHIRMYDLNSNNPNP 77 D++V W A SG + +Q ++++ + + +A ++++D+ Sbjct: 124 DNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQ--QQKR 181 Query: 78 IISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLH 137 + + + + S+ ++ + +G D+R + + + + Sbjct: 182 LRNMTSHSARVGSLSWNS--YILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWA 239 Query: 138 PNQAELIVGDQSGAIHIWDLKTDH----NEQLIPEPEVSITSAHIDP-DASYMAAVN--S 190 P+ L G +++W Q + + ++ + P ++ +A S Sbjct: 240 PDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTS 299 Query: 191 TGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCS--ADQTCKIWR 248 + +WN+ G + + AH++ +SP L + A IW+ Sbjct: 300 DRHIRIWNVCSGA--------CLSAVDAHSQ-VCSILWSPHYKELISGHGFAQNQLVIWK 350 Query: 249 TSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLW 297 + + EL + + S D + +A++D RLW Sbjct: 351 YPTMAKVAELKGHT--------SRVLSLTMSPDGATVASAAADETLRLW 391 Score = 121 bits (302), Expect = 5e-28, Method: Composition-based stats. Identities = 47/270 (17%), Positives = 95/270 (35%), Gaps = 23/270 (8%) Query: 10 SDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQ--HIRM 67 + LA V+ W R + ++V +L S I ++G + HI Sbjct: 157 KEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWN---SYILSSGSRSGHIHH 213 Query: 68 YDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDL---RSRNLQCQRI 124 +D+ + + G ++ + + + DGR + +GG D +W + Q Sbjct: 214 HDVRVAEH-HVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTF 272 Query: 125 FQVNAPINCVCLHPNQAELIV---GDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPD 181 Q + V P Q+ ++ G I IW++ + + + S P Sbjct: 273 TQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ-VCSILWSPH 331 Query: 182 ASYMAAVN--STGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCS 239 + + + + +W + ++ HT L SPD +A+ + Sbjct: 332 YKELISGHGFAQNQLVIWKYPT--------MAKVAELKGHTSRVLSLTMSPDGATVASAA 383 Query: 240 ADQTCKIWRTSNFSLMTELSIKSGNPGESS 269 AD+T ++WR + + +SS Sbjct: 384 ADETLRLWRCFELDPARRREREKASAAKSS 413 Score = 81.3 bits (199), Expect = 5e-16, Method: Composition-based stats. Identities = 26/157 (16%), Positives = 58/157 (36%), Gaps = 14/157 (8%) Query: 9 GSDPVILATAGYDHTVRFWQAHSG----ICTRTVQHQDSQVNALEVTP-DRSMIAAAG-- 61 D LA+ G D+ V W + G + +T V A+ P +++A G Sbjct: 239 APDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGT 298 Query: 62 -YQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYT--GGEDCTARIWDLRSRN 118 +HIR++++ S + D + S+ + + + + G IW + Sbjct: 299 SDRHIRIWNVCSGACLSAV--DAH-SQVCSILWSPHYKELISGHGFAQNQLVIWKYPT-M 354 Query: 119 LQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIW 155 + + + + + + P+ A + + +W Sbjct: 355 AKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 391 Score = 50.9 bits (120), Expect = 8e-07, Method: Composition-based stats. Identities = 20/104 (19%), Positives = 41/104 (39%), Gaps = 8/104 (7%) Query: 222 YALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGD 281 Y +S +LA D + +W S+ ++ L ++ ++ A+ + Sbjct: 107 YLNLVDWS-SGNVLAVA-LDNSVYLWSASSGDILQLLQMEQPG------EYISSVAWIKE 158 Query: 282 SQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDSVL 325 Y+ +S +LW V+ + R H V L++N +L Sbjct: 159 GNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYIL 202 Score = 27.4 bits (59), Expect = 8.6, Method: Composition-based stats. Identities = 8/21 (38%), Positives = 12/21 (57%) Query: 7 TVGSDPVILATAGYDHTVRFW 27 T+ D +A+A D T+R W Sbjct: 371 TMSPDGATVASAAADETLRLW 391 >5WJC-A nrPDB Length = 430 Score = 126 bits (315), Expect = 2e-29, Method: Composition-based stats. Identities = 46/272 (16%), Positives = 94/272 (34%), Gaps = 31/272 (11%) Query: 8 VGSDPVILATAGYDHTVRFWQAHSGICTRT--------VQHQDSQVNALEVTPD--RSMI 57 + P I+AT G + T ++ ++ L P+ ++ Sbjct: 140 MPQKPEIIATMGEGGNAYIFDTTCHDALTTGEALPQAVLKGHTAEGFGLCWNPNLPGNLA 199 Query: 58 AAAGYQHIRMYDLNSNNPN--------PIISYDGVNKNIASVGFHEDGR-WMYTGGEDCT 108 A Q I ++D+ + + PI Y + V FH + + +DCT Sbjct: 200 TGAEDQVICLWDVQTQSFTSSETKVISPIAKYHRHTDIVNDVQFHPQHEALLASVSDDCT 259 Query: 109 ARIWDLR-SRNLQCQRIFQVNA-PINCVCLHP-NQAELIVGDQSGAIHIWDLKTD-HNEQ 164 +I D R + + ++ Q ++ IN V ++P N L + +WDL+ Sbjct: 260 LQIHDTRLNPEEEAPKVIQAHSKAINAVAINPFNDYLLATASADKTVALWDLRNPYQRLH 319 Query: 165 LIPEPEVSITSAHIDP-DASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIP------ 217 + E + P D +A+ ++ +W+L ++ + Sbjct: 320 TLEGHEDEVYGLEWSPHDEPILASSSTDRRVCIWDLEKIGEEQTPEDAEDGSPELLFMHG 379 Query: 218 AHTRYALQCRFSPDSTLLATC-SADQTCKIWR 248 HT + + P+ + + D +IW Sbjct: 380 GHTNRISEFSWCPNERWVVGSLADDNILQIWS 411 Score = 92.1 bits (227), Expect = 3e-19, Method: Composition-based stats. Identities = 47/277 (16%), Positives = 94/277 (33%), Gaps = 48/277 (17%) Query: 84 VNKNIASVGFHEDGRWM-YTGGEDCTARIWDLR-------SRNLQCQRIFQVNAPINCVC 135 + ++ + + T GE A I+D L + A +C Sbjct: 130 HDGDVNRARYMPQKPEIIATMGEGGNAYIFDTTCHDALTTGEALPQAVLKGHTAEGFGLC 189 Query: 136 LHPN-QAELIVGDQSGAIHIWDLKTDHNEQL----------IPEPEVSITSAHIDPD-AS 183 +PN L G + I +WD++T + P + Sbjct: 190 WNPNLPGNLATGAEDQVICLWDVQTQSFTSSETKVISPIAKYHRHTDIVNDVQFHPQHEA 249 Query: 184 YMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSP-DSTLLATCSADQ 242 +A+V+ + + +E ++ I AH++ +P + LLAT SAD+ Sbjct: 250 LLASVSDDCTLQIHDTRLNPEEEAPKV-----IQAHSKAINAVAINPFNDYLLATASADK 304 Query: 243 TCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSG-DSQYIVTASSDNLARLWCVE- 300 T +W N + + E ++G +S D + ++S+D +W +E Sbjct: 305 TVALWDLRN-------PYQRLHTLEGHEDEVYGLEWSPHDEPILASSSTDRRVCIWDLEK 357 Query: 301 -------------TGEIKREYGGHQKAVVCLAFNDSV 324 + E+ +GGH + ++ + Sbjct: 358 IGEEQTPEDAEDGSPELLFMHGGHTNRISEFSWCPNE 394 Score = 72.5 bits (176), Expect = 2e-13, Method: Composition-based stats. Identities = 25/125 (20%), Positives = 51/125 (40%), Gaps = 16/125 (12%) Query: 4 SPGTVGSDPVILATAGYDHTVRFWQAHS-GICTRTVQHQDSQVNALEVTP-DRSMIAAAG 61 + + +LATA D TV W + T++ + +V LE +P D ++A++ Sbjct: 286 AVAINPFNDYLLATASADKTVALWDLRNPYQRLHTLEGHEDEVYGLEWSPHDEPILASSS 345 Query: 62 YQ-HIRMYDLNS------------NNPNPIISYDGVNKNIASVGFHEDGRWMY-TGGEDC 107 + ++DL +P + + G I+ + + RW+ + +D Sbjct: 346 TDRRVCIWDLEKIGEEQTPEDAEDGSPELLFMHGGHTNRISEFSWCPNERWVVGSLADDN 405 Query: 108 TARIW 112 +IW Sbjct: 406 ILQIW 410 >5LCW-Q nrPDB Length = 374 Score = 124 bits (311), Expect = 5e-29, Method: Composition-based stats. Identities = 49/287 (17%), Positives = 115/287 (40%), Gaps = 23/287 (8%) Query: 42 DSQVNALEVTPDRSMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMY 101 D +N ++ + +++A A + ++ +S + ++ + + I+SV + ++G ++ Sbjct: 59 DYYLNLVDWS-SGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLA 117 Query: 102 TGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLK-TD 160 G ++WD++ + + + + +A + + N L G +SG IH D++ + Sbjct: 118 VGTSSAEVQLWDVQQQK-RLRNMTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVRVAE 174 Query: 161 HNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHT 220 H+ + + PD ++A+ + VW G G +P H Sbjct: 175 HHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEG----GWVPLQTFTQHQ 230 Query: 221 RYALQCRFSP-DSTLLAT--CSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCA 277 + P S +LAT ++D+ +IW + + ++ + S + Sbjct: 231 GAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ---------VCSIL 281 Query: 278 FSGDSQYIVT--ASSDNLARLWCVETGEIKREYGGHQKAVVCLAFND 322 +S + +++ + N +W T E GH V+ L + Sbjct: 282 WSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSP 328 Score = 122 bits (307), Expect = 2e-28, Method: Composition-based stats. Identities = 41/289 (14%), Positives = 101/289 (34%), Gaps = 33/289 (11%) Query: 21 DHTVRFWQAHSGICTRTVQ--HQDSQVNALEVTPDRSMIAAA-GYQHIRMYDLNSNNPNP 77 D++V W A SG + +Q ++++ + + +A ++++D+ Sbjct: 78 DNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQ--QQKR 135 Query: 78 IISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLH 137 + + + + S+ ++ + +G D+R + + + + Sbjct: 136 LRNMTSHSARVGSLSWNS--YILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWA 193 Query: 138 PNQAELIVGDQSGAIHIWDLKTDH----NEQLIPEPEVSITSAHIDP-DASYMAAVN--S 190 P+ L G +++W Q + + ++ + P ++ +A S Sbjct: 194 PDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTS 253 Query: 191 TGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCS--ADQTCKIWR 248 + +WN+ G + + AH++ +SP L + A IW+ Sbjct: 254 DRHIRIWNVCSGA--------CLSAVDAHSQ-VCSILWSPHYKELISGHGFAQNQLVIWK 304 Query: 249 TSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLW 297 + + EL + + S D + +A++D RLW Sbjct: 305 YPTMAKVAELKGHT--------SRVLSLTMSPDGATVASAAADETLRLW 345 Score = 119 bits (298), Expect = 2e-27, Method: Composition-based stats. Identities = 47/270 (17%), Positives = 95/270 (35%), Gaps = 23/270 (8%) Query: 10 SDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQ--HIRM 67 + LA V+ W R + ++V +L S I ++G + HI Sbjct: 111 KEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWN---SYILSSGSRSGHIHH 167 Query: 68 YDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDL---RSRNLQCQRI 124 +D+ + + G ++ + + + DGR + +GG D +W + Q Sbjct: 168 HDVRVAEH-HVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTF 226 Query: 125 FQVNAPINCVCLHPNQAELIV---GDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPD 181 Q + V P Q+ ++ G I IW++ + + + S P Sbjct: 227 TQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ-VCSILWSPH 285 Query: 182 ASYMAAVN--STGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCS 239 + + + + +W + ++ HT L SPD +A+ + Sbjct: 286 YKELISGHGFAQNQLVIWKYPT--------MAKVAELKGHTSRVLSLTMSPDGATVASAA 337 Query: 240 ADQTCKIWRTSNFSLMTELSIKSGNPGESS 269 AD+T ++WR + + +SS Sbjct: 338 ADETLRLWRCFELDPARRREREKASAAKSS 367 Score = 80.2 bits (196), Expect = 1e-15, Method: Composition-based stats. Identities = 26/157 (16%), Positives = 58/157 (36%), Gaps = 14/157 (8%) Query: 9 GSDPVILATAGYDHTVRFWQAHSG----ICTRTVQHQDSQVNALEVTP-DRSMIAAAG-- 61 D LA+ G D+ V W + G + +T V A+ P +++A G Sbjct: 193 APDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGT 252 Query: 62 -YQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYT--GGEDCTARIWDLRSRN 118 +HIR++++ S + D + S+ + + + + G IW + Sbjct: 253 SDRHIRIWNVCSGACLSAV--DAH-SQVCSILWSPHYKELISGHGFAQNQLVIWKYPT-M 308 Query: 119 LQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIW 155 + + + + + + P+ A + + +W Sbjct: 309 AKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 345 Score = 50.1 bits (118), Expect = 1e-06, Method: Composition-based stats. Identities = 20/104 (19%), Positives = 41/104 (39%), Gaps = 8/104 (7%) Query: 222 YALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGD 281 Y +S +LA D + +W S+ ++ L ++ ++ A+ + Sbjct: 61 YLNLVDWS-SGNVLAVA-LDNSVYLWSASSGDILQLLQMEQPG------EYISSVAWIKE 112 Query: 282 SQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDSVL 325 Y+ +S +LW V+ + R H V L++N +L Sbjct: 113 GNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYIL 156 Score = 27.4 bits (59), Expect = 9.9, Method: Composition-based stats. Identities = 8/21 (38%), Positives = 12/21 (57%) Query: 7 TVGSDPVILATAGYDHTVRFW 27 T+ D +A+A D T+R W Sbjct: 325 TMSPDGATVASAAADETLRLW 345 >2HES-X nrPDB Length = 330 Score = 122 bits (306), Expect = 2e-28, Method: Composition-based stats. Identities = 47/305 (15%), Positives = 106/305 (34%), Gaps = 21/305 (6%) Query: 14 ILATAGYDHTVRF----WQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQ-HIRMY 68 ILAT D ++ + + I + ++ P S++AA + + ++ Sbjct: 26 ILATGSTDRKIKLVSVKYDDFTLIDVLDETAHKKAIRSVAWRPHTSLLAAGSFDSTVSIW 85 Query: 69 DLN-----SNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQR 123 + + + +G + V + DG ++ T D + IW+ + + Sbjct: 86 AKEESADRTFEMDLLAIIEGHENEVKGVAWSNDGYYLATCSRDKSVWIWETDESGEEYEC 145 Query: 124 IF---QVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTD--HNEQLIPEPEVSITSAHI 178 I + + + V HP++A L + IW D ++ E ++ S+ Sbjct: 146 ISVLQEHSQDVKHVIWHPSEALLASSSYDDTVRIWKDYDDDWECVAVLNGHEGTVWSSDF 205 Query: 179 DPDA--SYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPA-HTRYALQCRFSPDSTLL 235 D + + + VW G D+ + + + +P H R + + L+ Sbjct: 206 DKTEGVFRLCSGSDDSTVRVWKYMGDDEDDQQEWVCEAILPDVHKRQVYNVAWGFNG-LI 264 Query: 236 ATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLAR 295 A+ AD ++ + + ++ G + +G + T D + Sbjct: 265 ASVGADGVLAVYEEVDGEWKV-FAKRALCHGVYEINVVKWLELNG-KTILATGGDDGIVN 322 Query: 296 LWCVE 300 W +E Sbjct: 323 FWSLE 327 Score = 99.8 bits (247), Expect = 1e-21, Method: Composition-based stats. Identities = 37/200 (18%), Positives = 64/200 (32%), Gaps = 19/200 (9%) Query: 135 CLHPNQAELIVGDQSGAIHI----WDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNS 190 +Q L G I + +D T + + +I S P S +AA + Sbjct: 19 SFDFSQGILATGSTDRKIKLVSVKYDDFTLIDVLDETAHKKAIRSVAWRPHTSLLAAGSF 78 Query: 191 TGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIW--- 247 +W D ++ I H +S D LATCS D++ IW Sbjct: 79 DSTVSIW-AKEESADRTFEMDLLAIIEGHENEVKGVAWSNDGYYLATCSRDKSVWIWETD 137 Query: 248 -RTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETG--EI 304 + ++ L S + + + ++S D+ R+W E Sbjct: 138 ESGEEYECISVLQEHSQDVKH--------VIWHPSEALLASSSYDDTVRIWKDYDDDWEC 189 Query: 305 KREYGGHQKAVVCLAFNDSV 324 GH+ V F+ + Sbjct: 190 VAVLNGHEGTVWSSDFDKTE 209 Score = 85.2 bits (209), Expect = 4e-17, Method: Composition-based stats. Identities = 31/214 (14%), Positives = 69/214 (32%), Gaps = 22/214 (10%) Query: 9 GSDPVILATAGYDHTVRFWQA----HSGICTRTVQHQDSQVNALEVTPDRSMIAAAG-YQ 63 +D LAT D +V W+ C +Q V + P +++A++ Sbjct: 116 SNDGYYLATCSRDKSVWIWETDESGEEYECISVLQEHSQDVKHVIWHPSEALLASSSYDD 175 Query: 64 HIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDG--RWMYTGGEDCTARIWDL------R 115 +R++ ++ + +G + S F + + +G +D T R+W Sbjct: 176 TVRIWKDYDDDWECVAVLNGHEGTVWSSDFDKTEGVFRLCSGSDDSTVRVWKYMGDDEDD 235 Query: 116 SRNLQCQRIF--QVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPE----- 168 + C+ I + V N + G + +++ + Sbjct: 236 QQEWVCEAILPDVHKRQVYNVAWGFNG-LIASVGADGVLAVYEEVDGEWKVFAKRALCHG 294 Query: 169 -PEVSITSAHIDPDASYMAAVNSTGNCYVWNLTG 201 E+++ + +A G W+L Sbjct: 295 VYEINVVKWLELNGKTILATGGDDGIVNFWSLEK 328 >3JRO-A nrPDB Length = 753 Score = 122 bits (306), Expect = 2e-28, Method: Composition-based stats. Identities = 42/281 (14%), Positives = 91/281 (32%), Gaps = 31/281 (11%) Query: 41 QDSQVNALEVTPDRSMIAAAGYQ-HIRMYDLNSNNPNPIISYDGVNKNIASVGFHED--G 97 + ++ + +A I+++++ I + G + V + G Sbjct: 8 HNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFG 67 Query: 98 RWMYTGGEDCTARIWDLRSRNLQCQRIF-QVNAPINCVCLHPN--QAELIVGDQSGAIHI 154 + + D IW + + +A +N V P+ L+V G + + Sbjct: 68 TILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSV 127 Query: 155 WDLKTDHNEQ--LIPEPEVSITSAHIDP-------------DASYMAAVNSTGNCYVWNL 199 + K + +I + + SA P ++ + +W Sbjct: 128 VEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKY 187 Query: 200 TGGIGDEVTQLIPKTKIPAHTRYALQCRFSPD---STLLATCSADQTCKIWRTSNFSLMT 256 V ++ + H+ + +SP + LA+ S D+TC IW N Sbjct: 188 NSDAQTYVL----ESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPW 243 Query: 257 ELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLW 297 + ++ E +W ++S + + DN LW Sbjct: 244 KKTLL---KEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 Score = 118 bits (296), Expect = 3e-27, Method: Composition-based stats. Identities = 42/262 (16%), Positives = 88/262 (33%), Gaps = 31/262 (11%) Query: 15 LATAGYDHTVRFWQA--HSGICTRTVQHQDSQVNALEV--TPDRSMIAAAGYQ-HIRMYD 69 LAT D T++ ++ + T+ + V ++ +++A+ Y + ++ Sbjct: 24 LATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWK 83 Query: 70 LNSNNPNPIISYDGVNKNIASVGF--HEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQV 127 + + I + + ++ SV + HE G + D + + + I Sbjct: 84 EENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDA 143 Query: 128 NAP-INCVCLHP-------------NQAELIVGDQSGAIHIW----DLKTDHNEQLIPEP 169 +A +N P + + G + IW D +T E + Sbjct: 144 HAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGH 203 Query: 170 EVSITSAHIDPD---ASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQC 226 + P SY+A+V+ C +W G L+ + K P + Sbjct: 204 SDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDV---LWRA 260 Query: 227 RFSPDSTLLATCSADQTCKIWR 248 +S +LA D +W+ Sbjct: 261 SWSLSGNVLALSGGDNKVTLWK 282 Score = 96.0 bits (237), Expect = 2e-20, Method: Composition-based stats. Identities = 33/203 (16%), Positives = 69/203 (33%), Gaps = 23/203 (11%) Query: 140 QAELIVGDQSGAIHIWDLK--TDHNEQLIPEPEVSITSAHIDP--DASYMAAVNSTGNCY 195 L I I++++ T + E + + +A+ + G Sbjct: 21 GKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVL 80 Query: 196 VWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPD--STLLATCSADQTCKIWRTSNFS 253 +W G ++ H+ +++P LL S+D + Sbjct: 81 IWKEENGRWSQI------AVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENG 134 Query: 254 LMTELSIKSGNPGESSRGWMWGCAF-------SGDSQYIVTASSDNLARLW----CVETG 302 + + I + G +S W + +S+ VT +DNL ++W +T Sbjct: 135 TTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTY 194 Query: 303 EIKREYGGHQKAVVCLAFNDSVL 325 ++ GH V +A++ +VL Sbjct: 195 VLESTLEGHSDWVRDVAWSPTVL 217 Score = 91.7 bits (226), Expect = 4e-19, Method: Composition-based stats. Identities = 36/215 (16%), Positives = 69/215 (32%), Gaps = 29/215 (13%) Query: 12 PVILATAGYDHTVRFWQAHSGICTRTVQH--QDSQVNALEVTP---DRSMIAAAGYQHIR 66 ILA+ YD V W+ +G ++ H + VN+++ P ++ A+ + Sbjct: 67 GTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVS 126 Query: 67 MYDLNSNNPNPIISYDGVNKNIASVGFHE-------------DGRWMYTGGEDCTARIWD 113 + + N I D + S + + R TGG D +IW Sbjct: 127 VVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWK 186 Query: 114 LRSRNLQC---QRIFQVNAPINCVCLHPN---QAELIVGDQSGAIHIW--DLKTDHNEQL 165 S + + + V P ++ L Q IW D + ++ Sbjct: 187 YNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKT 246 Query: 166 IPEPEVS---ITSAHIDPDASYMAAVNSTGNCYVW 197 + + E + A + +A +W Sbjct: 247 LLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 Score = 59.4 bits (142), Expect = 2e-09, Method: Composition-based stats. Identities = 22/114 (19%), Positives = 37/114 (32%), Gaps = 10/114 (8%) Query: 217 PAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGC 276 AH LATCS+D+T KI+ + K + G +W Sbjct: 6 NAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGE------THKLIDTLTGHEGPVWRV 59 Query: 277 AFS--GDSQYIVTASSDNLARLWCVETGE--IKREYGGHQKAVVCLAFNDSVLG 326 ++ + + S D +W E G + H +V + + G Sbjct: 60 DWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYG 113 Score = 58.6 bits (140), Expect = 3e-09, Method: Composition-based stats. Identities = 20/128 (15%), Positives = 43/128 (33%), Gaps = 19/128 (14%) Query: 4 SPGTVGSDPV--------ILATAGYDHTVRFW----QAHSGICTRTVQHQDSQVNALEVT 51 +P T+ D T G D+ V+ W A + + T++ V + + Sbjct: 154 APATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWS 213 Query: 52 PD---RSMIAA-AGYQHIRMYDLNSNNPNPIISYDGVNKN---IASVGFHEDGRWMYTGG 104 P RS +A+ + + ++ ++ + K + + G + G Sbjct: 214 PTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSG 273 Query: 105 EDCTARIW 112 D +W Sbjct: 274 GDNKVTLW 281 >6CHG-A nrPDB Length = 312 Score = 121 bits (304), Expect = 3e-28, Method: Composition-based stats. Identities = 35/276 (12%), Positives = 96/276 (34%), Gaps = 7/276 (2%) Query: 35 TRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFH 94 + + + +++PD +IA + +Y+++S+ + + + I + + Sbjct: 6 KQVLPASGKISTSCQISPDGELIAICQNTDMLVYEISSSKMMKLTT--THKECINCLCWS 63 Query: 95 EDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHI 154 D + + +G ED T I + +R+ AP+ +C + L +I Sbjct: 64 PDSKCIASGSEDFTVEI--THIIYGRIRRLMGHTAPVISICYNNKGNILCSSSMDESIKE 121 Query: 155 WDLKTDHNEQLIPEPEVSITSAHI-DPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPK 213 W + + + + ++ S I D+S +++ + G +++ G + Sbjct: 122 WHVLSGTALKTMSAHSDAVVSIDIPKFDSSILSSGSYDGLIRIFDTESGHCLKTLTYDKD 181 Query: 214 TKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWM 273 +FS + L S D K+W + +++ + Sbjct: 182 WIAEDGVVPISTVKFSRNGKFLLVKSLDNVVKLWEYTRGTVVRTFLWPHQETKAKLKYNC 241 Query: 274 WGCAFSGDSQ--YIVTASSDNLARLWCVETGEIKRE 307 + +++ + +W V + + ++ Sbjct: 242 GLELIYPQGKDPLVISGNDSGSMCVWNVYSKNLVQK 277 Score = 102 bits (254), Expect = 2e-22, Method: Composition-based stats. Identities = 36/264 (13%), Positives = 89/264 (33%), Gaps = 17/264 (6%) Query: 7 TVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQ-HI 65 + D ++A + + ++ S + +N L +PD IA+ + Sbjct: 20 QISPDGELIAIC-QNTDMLVYEISSSKMMKLTTTHKECINCLCWSPDSKCIASGSEDFTV 78 Query: 66 RMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIF 125 + + I G + S+ ++ G + + D + + W + S Sbjct: 79 EITHIIYG---RIRRLMGHTAPVISICYNNKGNILCSSSMDESIKEWHVLSGTALKTMSA 135 Query: 126 QVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEV--------SITSAH 177 +A ++ + + L G G I I+D ++ H + + + I++ Sbjct: 136 HSDAVVSIDIPKFDSSILSSGSYDGLIRIFDTESGHCLKTLTYDKDWIAEDGVVPISTVK 195 Query: 178 IDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCR-FSPDST--L 234 + ++ + +W T G L P + A +Y P L Sbjct: 196 FSRNGKFLLVKSLDNVVKLWEYTRGTVVRTF-LWPHQETKAKLKYNCGLELIYPQGKDPL 254 Query: 235 LATCSADQTCKIWRTSNFSLMTEL 258 + + + + +W + +L+ ++ Sbjct: 255 VISGNDSGSMCVWNVYSKNLVQKI 278 Score = 101 bits (252), Expect = 4e-22, Method: Composition-based stats. Identities = 35/221 (15%), Positives = 83/221 (37%), Gaps = 12/221 (5%) Query: 89 ASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQ 148 S DG + ++ ++++ S + + INC+C P+ + G + Sbjct: 17 TSCQISPDGELIAI-CQNTDMLVYEISSSKMM-KLTTTHKECINCLCWSPDSKCIASGSE 74 Query: 149 SGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVT 208 + I + +L+ + S + + + + + + W++ G Sbjct: 75 DFTVEITHIIYGRIRRLM-GHTAPVISICYNNKGNILCSSSMDESIKEWHVLSGT----- 128 Query: 209 QLIPKTKIPAHTRYALQCRFSP-DSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGE 267 + AH+ + DS++L++ S D +I+ T + + L+ E Sbjct: 129 ---ALKTMSAHSDAVVSIDIPKFDSSILSSGSYDGLIRIFDTESGHCLKTLTYDKDWIAE 185 Query: 268 SSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREY 308 + FS + ++++ S DN+ +LW G + R + Sbjct: 186 DGVVPISTVKFSRNGKFLLVKSLDNVVKLWEYTRGTVVRTF 226 Score = 87.5 bits (215), Expect = 8e-18, Method: Composition-based stats. Identities = 38/219 (17%), Positives = 92/219 (42%), Gaps = 20/219 (9%) Query: 2 NTSPGTV---GSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTP-DRSMI 57 +T+P + IL ++ D +++ W SG +T+ V ++++ D S++ Sbjct: 94 HTAPVISICYNNKGNILCSSSMDESIKEWHVLSGTALKTMSAHSDAVVSIDIPKFDSSIL 153 Query: 58 AAAGYQH-IRMYDLNSNNPNPIISYDGV------NKNIASVGFHEDGRWMYTGGEDCTAR 110 ++ Y IR++D S + ++YD I++V F +G+++ D + Sbjct: 154 SSGSYDGLIRIFDTESGHCLKTLTYDKDWIAEDGVVPISTVKFSRNGKFLLVKSLDNVVK 213 Query: 111 IWDLRSRNL-------QCQRIFQVNAPINCVCLHPNQ--AELIVGDQSGAIHIWDLKTDH 161 +W+ + + ++ ++P +I G+ SG++ +W++ + + Sbjct: 214 LWEYTRGTVVRTFLWPHQETKAKLKYNCGLELIYPQGKDPLVISGNDSGSMCVWNVYSKN 273 Query: 162 NEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLT 200 Q I E + I +A ++ G C ++ + Sbjct: 274 LVQKIDEKHRNSPLISISASYDKVATLSLNGECNLFRVH 312 Score = 85.2 bits (209), Expect = 3e-17, Method: Composition-based stats. Identities = 25/184 (13%), Positives = 66/184 (35%), Gaps = 17/184 (9%) Query: 132 NCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNST 191 + P+ + + Q+ + ++++ + +L + I PD+ +A+ + Sbjct: 17 TSCQISPDGELIAIC-QNTDMLVYEISSSKMMKLTTTHKECINCLCWSPDSKCIASGSED 75 Query: 192 GNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSN 251 + ++ G ++ HT + ++ +L + S D++ K W + Sbjct: 76 FTVEITHIIYGR---------IRRLMGHTAPVISICYNNKGNILCSSSMDESIKEWHVLS 126 Query: 252 FSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGH 311 + + +S S DS + + S D L R++ E+G + Sbjct: 127 GTALKTMSAHSDAVVSIDIPKF-------DSSILSSGSYDGLIRIFDTESGHCLKTLTYD 179 Query: 312 QKAV 315 + + Sbjct: 180 KDWI 183 Score = 68.6 bits (166), Expect = 4e-12, Method: Composition-based stats. Identities = 33/166 (19%), Positives = 58/166 (34%), Gaps = 21/166 (12%) Query: 163 EQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRY 222 +Q++P TS I PD +A + T + E++ H Sbjct: 6 KQVLPASGKISTSCQISPDGELIA---------ICQNTDMLVYEISSSKMMKLTTTHKEC 56 Query: 223 ALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDS 282 +SPDS +A+ S D T +I T + + ++ Sbjct: 57 INCLCWSPDSKCIASGSEDFTVEI---------THIIYGRIRRLMGHTAPVISICYNNKG 107 Query: 283 QYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCL---AFNDSVL 325 + ++S D + W V +G + H AVV + F+ S+L Sbjct: 108 NILCSSSMDESIKEWHVLSGTALKTMSAHSDAVVSIDIPKFDSSIL 153 >5MWJ-A nrPDB Length = 337 Score = 121 bits (302), Expect = 6e-28, Method: Composition-based stats. Identities = 50/299 (16%), Positives = 103/299 (34%), Gaps = 27/299 (9%) Query: 7 TVGSDPVILATAGYDHTVRFWQAH---SGICTRTVQ--HQDSQVNALEVTPDR-SMIAAA 60 T+ + + T G V+ W + + ++D+ + + ++ PD ++I Sbjct: 58 TISNPTRHVYTGGK-GCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCKLLPDGCTLIVGG 116 Query: 61 GYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQ 120 + ++DL + P ++ D + ++ D +WDL ++ L Sbjct: 117 EASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTL- 175 Query: 121 CQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDP 180 ++ +C+ + + +L G + WDL+ Q + I S P Sbjct: 176 VRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQ-QHDFTSQIFSLGYCP 234 Query: 181 DASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSA 240 ++A + N V ++ K ++ H L +F+ + Sbjct: 235 TGEWLAVGMESSNVEVLHVNK---------PDKYQLHLHESCVLSLKFAYCGKWFVSTGK 285 Query: 241 DQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCV 299 D WRT + + + C S D +YIVT S D A ++ V Sbjct: 286 DNLLNAWRTPYGASI---------FQSKESSSVLSCDISVDDKYIVTGSGDKKATVYEV 335 Score = 81.7 bits (200), Expect = 4e-16, Method: Composition-based stats. Identities = 43/273 (15%), Positives = 81/273 (29%), Gaps = 75/273 (27%) Query: 40 HQDSQVNALEVTPDRSMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRW 99 D Q+ + PD ++I +H R +N+ N + + +V R Sbjct: 18 TADGQMQPVPFPPD-ALIGPGIPRHAR--QINTLN---------HGEVVCAVTISNPTRH 65 Query: 100 MYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKT 159 +YTGG+ G + +WD+ Sbjct: 66 VYTGGK--------------------------------------------GCVKVWDISH 81 Query: 160 DHNEQLIPE-----PEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKT 214 N+ + + + I S + PD + +W+L K Sbjct: 82 PGNKSPVSQLDCLNRDNYIRSCKLLPDGCTLIVGGEASTLSIWDLAAPTP------RIKA 135 Query: 215 KIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMW 274 ++ + SPDS + +C +D +W N +L+ + + Sbjct: 136 ELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQF--------QGHTDGAS 187 Query: 275 GCAFSGDSQYIVTASSDNLARLWCVETGEIKRE 307 S D + T DN R W + G ++ Sbjct: 188 CIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQ 220 Score = 71.7 bits (174), Expect = 4e-13, Method: Composition-based stats. Identities = 31/163 (19%), Positives = 55/163 (33%), Gaps = 11/163 (6%) Query: 161 HNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTG-GIGDEVTQLIPKTKIPAH 219 H Q+ + A + + G VW+++ G V+QL Sbjct: 41 HARQINTLNHGEVVCAVTISNPTRHVYTGGKGCVKVWDISHPGNKSPVSQLDCL----NR 96 Query: 220 TRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFS 279 Y C+ PD L T IW + + + + S P + A S Sbjct: 97 DNYIRSCKLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPA------CYALAIS 150 Query: 280 GDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFND 322 DS+ + SD +W + + R++ GH C+ ++ Sbjct: 151 PDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISN 193 >5L9T-R nrPDB Length = 493 Score = 120 bits (301), Expect = 7e-28, Method: Composition-based stats. Identities = 43/254 (16%), Positives = 87/254 (34%), Gaps = 16/254 (6%) Query: 12 PVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRM-YDL 70 ++A + V+ W A +G ++ ++V AL +++ + + D+ Sbjct: 241 GNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNA--EQLSSGSRDRMILQRDI 298 Query: 71 NSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAP 130 + G + + + + D + + +GG D +W+ S Q+ + A Sbjct: 299 RTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWN-HSSLSPVQQYTEHLAA 357 Query: 131 INCVCLHPNQAELIV---GDQSGAIHIWDLKTDHNEQLIPEPEVSIT-SAHIDPDASYMA 186 + + P+Q L+ G I W+ T Q I + + Sbjct: 358 VKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVST 417 Query: 187 AVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKI 246 S VW L K+ H+ L SPD + T + D+T + Sbjct: 418 HGYSQNQILVWKYPS--------LTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRF 469 Query: 247 WRTSNFSLMTELSI 260 W + + T+ S+ Sbjct: 470 WNVFSKTRSTKESV 483 Score = 114 bits (285), Expect = 5e-26, Method: Composition-based stats. Identities = 45/288 (15%), Positives = 99/288 (34%), Gaps = 28/288 (9%) Query: 42 DSQVNALEVTPDRSMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMY 101 D +N ++ + ++++ + ++ ++ + ++ SVG+ E G + Sbjct: 187 DFYLNLVDWS-SLNVLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVA 245 Query: 102 TGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTD- 160 G +IWD + + + A + + N +L G + I D++T Sbjct: 246 VGTHKGFVQIWDAAAGK-KLSMLEGHTARVGALAW--NAEQLSSGSRDRMILQRDIRTPP 302 Query: 161 -HNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAH 219 +E+ + + D +A+ + VWN + L P + H Sbjct: 303 LQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWN--------HSSLSPVQQYTEH 354 Query: 220 TRYALQCRFSPDSTLLAT---CSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGC 276 +SP L +AD+ + W T + + + + Sbjct: 355 LAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCI---------DTGSQVCNL 405 Query: 277 AFSGDSQYIVT--ASSDNLARLWCVETGEIKREYGGHQKAVVCLAFND 322 A+S + +V+ S N +W + + GH V+ LA + Sbjct: 406 AWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSP 453 Score = 110 bits (275), Expect = 9e-25, Method: Composition-based stats. Identities = 43/296 (14%), Positives = 103/296 (34%), Gaps = 34/296 (11%) Query: 15 LATAGYDHTVRFWQA----HSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQH-IRMYD 69 + + G V W A + +C +V+ V ++ + +++A ++ ++++D Sbjct: 200 VLSVGLGTCVYLWSACTSQVTRLCDLSVEG--DSVTSVGWSERGNLVAVGTHKGFVQIWD 257 Query: 70 LNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVN- 128 + + +G + ++ ++ + + +G D D+R+ LQ +R Q + Sbjct: 258 AAAGKKLSM--LEGHTARVGALAWNAE--QLSSGSRDRMILQRDIRTPPLQSERRLQGHR 313 Query: 129 APINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAV 188 + + + L G + +W+ + Q E ++ + P + A Sbjct: 314 QEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLAS 373 Query: 189 N---STGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLAT--CSADQT 243 + WN G + +S + L + + Sbjct: 374 GGGTADRCIRFWNTLTGQPLQCI---------DTGSQVCNLAWSKHANELVSTHGYSQNQ 424 Query: 244 CKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCV 299 +W+ + + + +L+ S + A S D + IVT + D R W V Sbjct: 425 ILVWKYPSLTQVAKLTGHSYR--------VLYLAMSPDGEAIVTGAGDETLRFWNV 472 Score = 81.3 bits (199), Expect = 5e-16, Method: Composition-based stats. Identities = 23/155 (14%), Positives = 59/155 (38%), Gaps = 10/155 (6%) Query: 9 GSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAG----YQH 64 +D +LA+ G D+ + W S + + V A+ +P + + A+G + Sbjct: 322 STDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRC 381 Query: 65 IRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYT--GGEDCTARIWDLRSRNLQCQ 122 IR ++ + P I + ++ + + + + G +W S Q Sbjct: 382 IRFWNTLTGQPLQCIDT---GSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLT-QVA 437 Query: 123 RIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDL 157 ++ + + + + P+ ++ G + W++ Sbjct: 438 KLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNV 472 >3C9C-A nrPDB Length = 432 Score = 120 bits (301), Expect = 8e-28, Method: Composition-based stats. Identities = 42/243 (17%), Positives = 93/243 (38%), Gaps = 22/243 (9%) Query: 30 HSGICT--RTVQHQDSQVNALEVTPDRS-MIAAAGYQH-IRMYDLN-SNNPNPIIS---- 80 SG C ++ + L P+ + + +A H I ++D+N + + +I Sbjct: 169 PSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNI 228 Query: 81 YDGVNKNIASVGFHEDGRWMY-TGGEDCTARIWDLRSRNL--QCQRIFQVNAPINCVCLH 137 + G + V +H ++ + +D IWD R+ N + A +NC+ + Sbjct: 229 FTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFN 288 Query: 138 P-NQAELIVGDQSGAIHIWDLKTDH-NEQLIPEPEVSITSAHIDP-DASYMAAVNSTGNC 194 P ++ L G + +WDL+ + I P + + +A+ + Sbjct: 289 PYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRL 348 Query: 195 YVWNLTGGIGDEVTQLIPKTKIP------AHTRYALQCRFSPDSTL-LATCSADQTCKIW 247 +VW+L+ ++ T+ HT ++P+ + + S D ++W Sbjct: 349 HVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVW 408 Query: 248 RTS 250 + + Sbjct: 409 QMA 411 Score = 117 bits (292), Expect = 9e-27, Method: Composition-based stats. Identities = 41/291 (14%), Positives = 101/291 (34%), Gaps = 37/291 (12%) Query: 40 HQDSQVNALEVTPDRSMIAAAG--YQHIRMYDLN--------SNNPNPIISYDGVNKNIA 89 + + +VN P + + A + ++D S P + G K Sbjct: 128 NHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGY 187 Query: 90 SVGFHED-GRWMYTGGEDCTARIWDLRSRNLQCQ------RIFQVNAPINCVCLH-PNQA 141 + ++ + ++ + +D T +WD+ + + + A + V H +++ Sbjct: 188 GLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHES 247 Query: 142 ELIVGDQSGAIHIWDLK---TDHNEQLIPEPEVSITSAHIDPDASY-MAAVNSTGNCYVW 197 + IWD + T + + +P + + +A ++ +W Sbjct: 248 LFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALW 307 Query: 198 NLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDS-TLLATCSADQTCKIWRTSN-FSLM 255 +L + +H Q ++SP + T+LA+ D+ +W S Sbjct: 308 DLRNLKLKLHS-------FESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQ 360 Query: 256 TELSIKSGNP-----GESSRGWMWGCAFSGDSQY-IVTASSDNLARLWCVE 300 + + G P + +++ + + I + S DN+ ++W + Sbjct: 361 STEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMA 411 Score = 104 bits (258), Expect = 8e-23, Method: Composition-based stats. Identities = 43/233 (18%), Positives = 82/233 (35%), Gaps = 27/233 (11%) Query: 15 LATAGYDHTVRFWQAHSG-------ICTRTVQHQDSQVNALEVT--PDRSMIAAAGYQHI 65 L +A DHT+ W ++ + V + + + A Q + Sbjct: 199 LLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKL 258 Query: 66 RMYDLNSNNP-NPIISYDGVNKNIASVGFHEDGRW-MYTGGEDCTARIWDLRSRNLQCQR 123 ++D +NN P + D + + F+ + + TG D T +WDLR+ L+ Sbjct: 259 MIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHS 318 Query: 124 IFQVNAPINCVCLHP-NQAELIVGDQSGAIHIWDLKTDHNEQLIP--------------E 168 I V P N+ L +H+WDL EQ Sbjct: 319 FESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGG 378 Query: 169 PEVSITSAHIDPDASYMA-AVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHT 220 I+ +P+ ++ +V+ VW + + ++ IP +++ +T Sbjct: 379 HTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENVYNDEEPEIPASELETNT 431 Score = 94.1 bits (232), Expect = 8e-20, Method: Composition-based stats. Identities = 41/276 (14%), Positives = 83/276 (30%), Gaps = 47/276 (17%) Query: 84 VNKNIASVGFHEDG-RWMYTGGEDCTARIWDL------RSRNLQCQ---RIFQVNAPINC 133 + + + T ++D + +CQ R+ Sbjct: 129 HEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYG 188 Query: 134 VCLHPN-QAELIVGDQSGAIHIWDLKTDHNEQ-------LIPEPEVSITSAHIDPD-ASY 184 + +PN L+ I +WD+ E + + S Sbjct: 189 LSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESL 248 Query: 185 MAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLL-ATCSADQT 243 +V +W+ + P + AHT F+P S + AT SAD+T Sbjct: 249 FGSVADDQKLMIWDTRNNNTSK-----PSHTVDAHTAEVNCLSFNPYSEFILATGSADKT 303 Query: 244 CKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSG-DSQYIVTASSDNLARLWCVET- 301 +W N L + ES + ++ +S + + ++ +D +W + Sbjct: 304 VALWDLRNLKLKL-------HSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKI 356 Query: 302 -------------GEIKREYGGHQKAVVCLAFNDSV 324 E+ +GGH + ++N + Sbjct: 357 GEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNE 392 Score = 64.8 bits (156), Expect = 5e-11, Method: Composition-based stats. Identities = 18/115 (15%), Positives = 44/115 (38%), Gaps = 16/115 (13%) Query: 14 ILATAGYDHTVRFWQAHSGIC-TRTVQHQDSQVNALEVTP--DRSMIAAAGYQHIRMYDL 70 ILAT D TV W + + + ++ ++ +P + + ++ + + ++DL Sbjct: 294 ILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDL 353 Query: 71 ------------NSNNPNPIISYDGVNKNIASVGFHEDGRWMY-TGGEDCTARIW 112 P + + G I+ ++ + W+ + ED ++W Sbjct: 354 SKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVW 408 Score = 34.4 bits (77), Expect = 0.070, Method: Composition-based stats. Identities = 12/83 (14%), Positives = 27/83 (32%), Gaps = 16/83 (19%) Query: 11 DPVILATAGYDHTVRFWQAHS-GICTRT-------------VQHQDSQVNALEVTPDRSM 56 + ILA++G D + W G T ++++ P+ Sbjct: 335 NETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPW 394 Query: 57 IAA--AGYQHIRMYDLNSNNPNP 77 I + ++++ + N N Sbjct: 395 IICSVSEDNIMQVWQMAENVYND 417 >4N14-A nrPDB Length = 314 Score = 119 bits (299), Expect = 1e-27, Method: Composition-based stats. Identities = 49/287 (17%), Positives = 115/287 (40%), Gaps = 23/287 (8%) Query: 42 DSQVNALEVTPDRSMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMY 101 D +N ++ + +++A A + ++ +S + ++ + + I+SV + ++G ++ Sbjct: 21 DYYLNLVDWS-SGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLA 79 Query: 102 TGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLK-TD 160 G ++WD++ + + + + +A + + N L G +SG IH D++ + Sbjct: 80 VGTSSAEVQLWDVQQQK-RLRNMTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVRVAE 136 Query: 161 HNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHT 220 H+ + + PD ++A+ + VW G G +P H Sbjct: 137 HHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEG----GWVPLQTFTQHQ 192 Query: 221 RYALQCRFSP-DSTLLAT--CSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCA 277 + P S +LAT ++D+ +IW + + ++ + S + Sbjct: 193 GAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ---------VCSIL 243 Query: 278 FSGDSQYIVT--ASSDNLARLWCVETGEIKREYGGHQKAVVCLAFND 322 +S + +++ + N +W T E GH V+ L + Sbjct: 244 WSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSP 290 Score = 117 bits (294), Expect = 5e-27, Method: Composition-based stats. Identities = 41/289 (14%), Positives = 101/289 (34%), Gaps = 33/289 (11%) Query: 21 DHTVRFWQAHSGICTRTVQ--HQDSQVNALEVTPDRSMIAAA-GYQHIRMYDLNSNNPNP 77 D++V W A SG + +Q ++++ + + +A ++++D+ Sbjct: 40 DNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQ--QQKR 97 Query: 78 IISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLH 137 + + + + S+ ++ + +G D+R + + + + Sbjct: 98 LRNMTSHSARVGSLSWNS--YILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWA 155 Query: 138 PNQAELIVGDQSGAIHIWDLKTDH----NEQLIPEPEVSITSAHIDP-DASYMAAVN--S 190 P+ L G +++W Q + + ++ + P ++ +A S Sbjct: 156 PDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTS 215 Query: 191 TGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCS--ADQTCKIWR 248 + +WN+ G + + AH++ +SP L + A IW+ Sbjct: 216 DRHIRIWNVCSGA--------CLSAVDAHSQ-VCSILWSPHYKELISGHGFAQNQLVIWK 266 Query: 249 TSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLW 297 + + EL + + S D + +A++D RLW Sbjct: 267 YPTMAKVAELKGHT--------SRVLSLTMSPDGATVASAAADETLRLW 307 Score = 114 bits (285), Expect = 5e-26, Method: Composition-based stats. Identities = 45/250 (18%), Positives = 90/250 (36%), Gaps = 23/250 (9%) Query: 10 SDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQ--HIRM 67 + LA V+ W R + ++V +L S I ++G + HI Sbjct: 73 KEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWN---SYILSSGSRSGHIHH 129 Query: 68 YDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDL---RSRNLQCQRI 124 +D+ + + G ++ + + + DGR + +GG D +W + Q Sbjct: 130 HDVRVAEH-HVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTF 188 Query: 125 FQVNAPINCVCLHPNQAELIV---GDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPD 181 Q + V P Q+ ++ G I IW++ + + + S P Sbjct: 189 TQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ-VCSILWSPH 247 Query: 182 ASYMAAVN--STGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCS 239 + + + + +W + ++ HT L SPD +A+ + Sbjct: 248 YKELISGHGFAQNQLVIWKYPT--------MAKVAELKGHTSRVLSLTMSPDGATVASAA 299 Query: 240 ADQTCKIWRT 249 AD+T ++WR Sbjct: 300 ADETLRLWRC 309 Score = 77.1 bits (188), Expect = 9e-15, Method: Composition-based stats. Identities = 25/157 (15%), Positives = 58/157 (36%), Gaps = 14/157 (8%) Query: 9 GSDPVILATAGYDHTVRFWQAHSG----ICTRTVQHQDSQVNALEVTP-DRSMIAAAG-- 61 D LA+ G D+ V W + G + +T V A+ P +++A G Sbjct: 155 APDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGT 214 Query: 62 -YQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYT--GGEDCTARIWDLRSRN 118 +HIR++++ S + + + S+ + + + + G IW + Sbjct: 215 SDRHIRIWNVCSGACLSAVD---AHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPT-M 270 Query: 119 LQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIW 155 + + + + + + P+ A + + +W Sbjct: 271 AKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 307 Score = 48.6 bits (114), Expect = 4e-06, Method: Composition-based stats. Identities = 20/104 (19%), Positives = 41/104 (39%), Gaps = 8/104 (7%) Query: 222 YALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGD 281 Y +S +LA D + +W S+ ++ L ++ ++ A+ + Sbjct: 23 YLNLVDWS-SGNVLAVA-LDNSVYLWSASSGDILQLLQMEQPG------EYISSVAWIKE 74 Query: 282 SQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDSVL 325 Y+ +S +LW V+ + R H V L++N +L Sbjct: 75 GNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYIL 118 >4J0W-A nrPDB Length = 343 Score = 119 bits (299), Expect = 1e-27, Method: Composition-based stats. Identities = 46/308 (14%), Positives = 95/308 (30%), Gaps = 33/308 (10%) Query: 35 TRTVQHQDSQVNALEVTPDRSMIAAAGYQ-HIRMYDLNSNNPNPII---------SYDGV 84 R ++ + L VTPD S I +A I + + S +I G Sbjct: 7 IRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGH 66 Query: 85 NKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELI 144 + ++ + DG+++ +G IW+ +S ++ + +L Sbjct: 67 SSHVLCMAISSDGKYLASGDRSKLILIWEAQS-CQHLYTFTGHRDAVSGLAFRRGTHQLY 125 Query: 145 VGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIG 204 ++ +W++ + + + + ++ + + A G VW + Sbjct: 126 STSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPE--- 182 Query: 205 DEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFS---LMTELSIK 261 + H + + + + D + +W S L E Sbjct: 183 ------ESQLVFYGHQGSIDCIHLI-NEEHMVSGADDGSVALWGLSKKRPLALQREAHGL 235 Query: 262 SGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETG------EIKREYGGHQKAV 315 G PG W+ A ++ + T S + RLW G G + Sbjct: 236 RGEPGLEQPFWISSVAALLNTDLVATGSHSSCVRLWQCGEGFRQLDLLCDIPLVG---FI 292 Query: 316 VCLAFNDS 323 L F+ S Sbjct: 293 NSLKFSSS 300 Score = 117 bits (292), Expect = 9e-27, Method: Composition-based stats. Identities = 40/297 (13%), Positives = 100/297 (33%), Gaps = 25/297 (8%) Query: 7 TVGSDPVILATAGYDHTVRFWQAHSGICTRTVQ-----------HQDSQVNALEVTPDRS 55 V D + +A D ++ W SG + S V + ++ D Sbjct: 21 VVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSHVLCMAISSDGK 80 Query: 56 MIAAAGYQH-IRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDL 114 +A+ I +++ S + ++ G ++ + F +Y+ D + ++W++ Sbjct: 81 YLASGDRSKLILIWEAQS--CQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNV 138 Query: 115 RSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSIT 174 + N + +F + + + + G + G + +W + ++ + + SI Sbjct: 139 -AENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPE-ESQLVFYGHQGSID 196 Query: 175 SAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEV-TQLIPKTKIPAHTRY--ALQCRFSPD 231 H+ + +M + G+ +W L+ + + P + + Sbjct: 197 CIHL-INEEHMVSGADDGSVALWGLSKKRPLALQREAHGLRGEPGLEQPFWISSVAALLN 255 Query: 232 STLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTA 288 + L+AT S ++W G++ FS ++V Sbjct: 256 TDLVATGSHSSCVRLW-----QCGEGFRQLDLLCDIPLVGFINSLKFSSSGDFLVAG 307 >5A9Q-2 nrPDB Length = 326 Score = 119 bits (298), Expect = 1e-27, Method: Composition-based stats. Identities = 54/281 (19%), Positives = 100/281 (35%), Gaps = 30/281 (10%) Query: 32 GICTRTVQHQDSQVNALEVTPDR---------SMIAAAGYQHIRMYDLNSNNPNPIISYD 82 RT H +V+ + +P+ +A IR++ + + N + Sbjct: 63 YKTLRTF-HHGVRVDGIAWSPETRLDSLPPVIKFCTSAADMKIRLFTSDLQDKNEYKVLE 121 Query: 83 GVNKNIASVGFHE-DGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQA 141 G I + F +G+ + + +D T RIW+L F +++P VC HP + Sbjct: 122 GHTDFINGLVFDPKEGQEIASVSDDHTCRIWNLEGVQTAH---FVLHSPGMSVCWHPEET 178 Query: 142 -ELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLT 200 +L+V +++G I +DL + +V + SAH ++ + + +W++T Sbjct: 179 FKLMVAEKNGTIRFYDLLAQQAILSLESEQVPLMSAHWCLKNTFKVGAVAGNDWLIWDIT 238 Query: 201 GGIGDEVTQLIPKTKIPAHTRYALQCRFSP-DSTLLATCSADQTCKIWRTSNFSLMTELS 259 P+ K P H A R+S L AT ++ + L Sbjct: 239 -------RSSYPQNKRPVHMDRACLFRWSTISENLFATTGYPGKM-----ASQFQIHHL- 285 Query: 260 IKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVE 300 S G ++ V D+ W E Sbjct: 286 GHPQPILMGSVAVGSGLSWHRTLPLCVIGG-DHKLLFWVTE 325 Score = 65.2 bits (157), Expect = 3e-11, Method: Composition-based stats. Identities = 23/169 (13%), Positives = 51/169 (30%), Gaps = 22/169 (13%) Query: 113 DLRSRNLQCQRIFQVNAPINCVCLHPNQAE--------LIVGDQSGAIHIW--DLKTDHN 162 D+ + R F ++ + P I ++ DL+ + Sbjct: 57 DVEGIQYKTLRTFHHGVRVDGIAWSPETRLDSLPPVIKFCTSAADMKIRLFTSDLQDKNE 116 Query: 163 EQLIPEPEVSITSAHIDP-DASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTR 221 +++ I DP + +A+V+ C +WNL G + H+ Sbjct: 117 YKVLEGHTDFINGLVFDPKEGQEIASVSDDHTCRIWNLEG---------VQTAHFVLHSP 167 Query: 222 YALQCRFSPDSTL-LATCSADQTCKIWRTSNFSLMTELSIKSGNPGESS 269 + + P+ T L + T + + + L + + Sbjct: 168 G-MSVCWHPEETFKLMVAEKNGTIRFYDLLAQQAILSLESEQVPLMSAH 215 Score = 48.6 bits (114), Expect = 4e-06, Method: Composition-based stats. Identities = 22/116 (18%), Positives = 44/116 (37%), Gaps = 17/116 (14%) Query: 219 HTRYALQCRFSPDSTL--------LATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSR 270 H +SP++ L T +AD +++ TS+ E + G+ Sbjct: 71 HGVRVDGIAWSPETRLDSLPPVIKFCTSAADMKIRLF-TSDLQDKNEYKVLEGHT----- 124 Query: 271 GWMWGCAFSG-DSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDSVL 325 ++ G F + Q I + S D+ R+W +E G + H + + ++ Sbjct: 125 DFINGLVFDPKEGQEIASVSDDHTCRIWNLE-GVQTAHFVLHSPG-MSVCWHPEET 178 >4L9O-A nrPDB Length = 349 Score = 119 bits (298), Expect = 2e-27, Method: Composition-based stats. Identities = 44/273 (16%), Positives = 84/273 (30%), Gaps = 23/273 (8%) Query: 41 QDSQVNALEVTPDRSMIAAAGYQ-HIRMYDLNSNNPNPIISYDGVNKNIASVGFHED--G 97 D ++ + +A I++++++ N + + G + V + G Sbjct: 68 HDDLIHDAVLDYYGRRLATCSSDKTIKIFEIDGENQRLVETLIGHEGPVWQVAWAHPKFG 127 Query: 98 RWMYTGGEDCTARIWDLRSRNLQCQRIFQ-VNAPINCVCLHPN--QAELIVGDQSGAIHI 154 + + D IW + A +N V P+ L+ G I I Sbjct: 128 VILASCSYDGKVLIWKEDNGVWNKVAEHSVHQASVNSVSWAPHEYGPVLLCASSDGKISI 187 Query: 155 WDLKTDHNEQ--LIPEPEVSITSAHIDP-----DASYMAAVNSTGNCYVWNLTGGIGDEV 207 + K + +I + + +A P + + +W D Sbjct: 188 VEFKDGGALEPIVIQGHAIGVNAASWAPISLPDNTRRFVSGGCDNLVKIWRYD----DAA 243 Query: 208 TQLIPKTKIPAHTRYALQCRFSPDS---TLLATCSADQTCKIWRTSNFSLMTELSIKSGN 264 I + H+ + +SP + +AT S D+T IW S E Sbjct: 244 KTFIEEEAFQGHSDWVRDVAWSPSRLSKSYIATASQDRTVLIWTKDGKSNKWEKQPL--- 300 Query: 265 PGESSRGWMWGCAFSGDSQYIVTASSDNLARLW 297 E W ++S + + DN LW Sbjct: 301 TKEKFPDVCWRASWSLSGNVLAISGGDNKVTLW 333 Score = 108 bits (270), Expect = 3e-24, Method: Composition-based stats. Identities = 43/254 (16%), Positives = 82/254 (32%), Gaps = 23/254 (9%) Query: 15 LATAGYDHTVRFW--QAHSGICTRTVQHQDSQVNALEV--TPDRSMIAAAGYQ-HIRMYD 69 LAT D T++ + + T+ + V + ++A+ Y + ++ Sbjct: 84 LATCSSDKTIKIFEIDGENQRLVETLIGHEGPVWQVAWAHPKFGVILASCSYDGKVLIWK 143 Query: 70 LNSNNPNPIISYDGVNKNIASVGF--HEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQV 127 ++ N + + ++ SV + HE G + D I + + + Q Sbjct: 144 EDNGVWNKVAEHSVHQASVNSVSWAPHEYGPVLLCASSDGKISIVEFKDGGALEPIVIQG 203 Query: 128 NAP-INCVCLHP-----NQAELIVGDQSGAIHIWD----LKTDHNEQLIPEPEVSITSAH 177 +A +N P N + G + IW KT E+ + Sbjct: 204 HAIGVNAASWAPISLPDNTRRFVSGGCDNLVKIWRYDDAAKTFIEEEAFQGHSDWVRDVA 263 Query: 178 IDP---DASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTL 234 P SY+A + +W G Q + K K P + +S + Sbjct: 264 WSPSRLSKSYIATASQDRTVLIWTKDGKSNKWEKQPLTKEKFPDV---CWRASWSLSGNV 320 Query: 235 LATCSADQTCKIWR 248 LA D +W+ Sbjct: 321 LAISGGDNKVTLWK 334 Score = 94.4 bits (233), Expect = 6e-20, Method: Composition-based stats. Identities = 35/207 (16%), Positives = 72/207 (34%), Gaps = 21/207 (10%) Query: 12 PVILATAGYDHTVRFWQAHSGICTRTVQH--QDSQVNALEVTPDRS---MIAAAGYQHIR 66 VILA+ YD V W+ +G+ + +H + VN++ P ++ A+ I Sbjct: 127 GVILASCSYDGKVLIWKEDNGVWNKVAEHSVHQASVNSVSWAPHEYGPVLLCASSDGKIS 186 Query: 67 MYDLNSNNPNPIISYDGVNKNIASVGFHE-----DGRWMYTGGEDCTARIW---DLRSRN 118 + + I G + + + + R +GG D +IW D Sbjct: 187 IVEFKDGGALEPIVIQGHAIGVNAASWAPISLPDNTRRFVSGGCDNLVKIWRYDDAAKTF 246 Query: 119 LQCQRIFQVNAPINCVCLHP---NQAELIVGDQSGAIHIW--DLKTDHNEQ---LIPEPE 170 ++ + + + V P +++ + Q + IW D K++ E+ + Sbjct: 247 IEEEAFQGHSDWVRDVAWSPSRLSKSYIATASQDRTVLIWTKDGKSNKWEKQPLTKEKFP 306 Query: 171 VSITSAHIDPDASYMAAVNSTGNCYVW 197 A + +A +W Sbjct: 307 DVCWRASWSLSGNVLAISGGDNKVTLW 333 Score = 90.2 bits (222), Expect = 1e-18, Method: Composition-based stats. Identities = 30/196 (15%), Positives = 66/196 (33%), Gaps = 17/196 (8%) Query: 140 QAELIVGDQSGAIHIW--DLKTDHNEQLIPEPEVSITSAHIDP--DASYMAAVNSTGNCY 195 L I I+ D + + + E + +A+ + G Sbjct: 81 GRRLATCSSDKTIKIFEIDGENQRLVETLIGHEGPVWQVAWAHPKFGVILASCSYDGKVL 140 Query: 196 VWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPD--STLLATCSADQTCKIWRTSNFS 253 +W G+ ++V + H ++P +L S+D I + Sbjct: 141 IWKEDNGVWNKV------AEHSVHQASVNSVSWAPHEYGPVLLCASSDGKISIVEFKDGG 194 Query: 254 LMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEI----KREYG 309 + + I+ G ++ W + +++ V+ DNL ++W + + + Sbjct: 195 ALEPIVIQGHAIGVNAASWAP-ISLPDNTRRFVSGGCDNLVKIWRYDDAAKTFIEEEAFQ 253 Query: 310 GHQKAVVCLAFNDSVL 325 GH V +A++ S L Sbjct: 254 GHSDWVRDVAWSPSRL 269 Score = 58.2 bits (139), Expect = 4e-09, Method: Composition-based stats. Identities = 27/120 (22%), Positives = 43/120 (35%), Gaps = 14/120 (11%) Query: 213 KTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIW--RTSNFSLMTELSIKSGNPGESSR 270 T AH LATCS+D+T KI+ N L+ L Sbjct: 62 VTIGNAHDDLIHDAVLDYYGRRLATCSSDKTIKIFEIDGENQRLVETL--------IGHE 113 Query: 271 GWMWGCAFS--GDSQYIVTASSDNLARLWCVETG--EIKREYGGHQKAVVCLAFNDSVLG 326 G +W A++ + + S D +W + G E+ HQ +V +++ G Sbjct: 114 GPVWQVAWAHPKFGVILASCSYDGKVLIWKEDNGVWNKVAEHSVHQASVNSVSWAPHEYG 173 Score = 54.4 bits (129), Expect = 6e-08, Method: Composition-based stats. Identities = 21/120 (17%), Positives = 43/120 (35%), Gaps = 11/120 (9%) Query: 4 SPGTVGSDPVILATAGYDHTVRFWQ----AHSGICTRTVQHQDSQVNALEVTP---DRSM 56 +P ++ + + G D+ V+ W+ A + I Q V + +P +S Sbjct: 214 APISLPDNTRRFVSGGCDNLVKIWRYDDAAKTFIEEEAFQGHSDWVRDVAWSPSRLSKSY 273 Query: 57 IAAAG-YQHIRMY--DLNSNN-PNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIW 112 IA A + + ++ D SN ++ + + G + G D +W Sbjct: 274 IATASQDRTVLIWTKDGKSNKWEKQPLTKEKFPDVCWRASWSLSGNVLAISGGDNKVTLW 333 >6ELZ-p nrPDB Length = 460 Score = 119 bits (298), Expect = 2e-27, Method: Composition-based stats. Identities = 50/349 (14%), Positives = 109/349 (31%), Gaps = 68/349 (19%) Query: 8 VGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRM 67 VG + + YD VR W SG + + A++ + +++A + +R+ Sbjct: 111 VGDGSKHIISGSYDGIVRTWDL-SGNVQKQYSGHSGPIRAVKYISNTRLVSAGNDRTLRL 169 Query: 68 Y---------------------DLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGED 106 + ++N + + +G + S+ D + + D Sbjct: 170 WKTKNDDLKLTSQQQAQEDDDDEVNIEDGKTLAILEGHKAPVVSIDVS-DNSRILSASYD 228 Query: 107 CTARIW--------------DLRSRNLQCQR-----------------------IFQVNA 129 + W D+ + N + + A Sbjct: 229 NSIGFWSTIYKEMTVVDPLEDINNPNNKISTAARKRRKLTMKDGTIRRRAPLSLLESHTA 288 Query: 130 PINCVCL-HPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAV 188 P+ V + Q I WDL T S+ S + +A Sbjct: 289 PVEQVIFDSTDNTVGYSVSQDHTIKTWDLVTARCIDT-RTTSYSLLSIAQLSTLNLLACG 347 Query: 189 NSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSP-DSTLLATCSADQTCKIW 247 +S + + + G +VTQ ++ H + P + +L + S D T K+W Sbjct: 348 SSARHITLHDPRVGASSKVTQQ----QLIGHKNFVSSLDTCPENEYILCSGSHDGTVKVW 403 Query: 248 RTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARL 296 + S M ++ + + + ++ + + I++A D ++ Sbjct: 404 DVRSTSPMYTITREDKSVQKGVNDKVFAVKW-AEKVGIISAGQDKKIQI 451 Score = 83.7 bits (205), Expect = 1e-16, Method: Composition-based stats. Identities = 41/337 (12%), Positives = 92/337 (27%), Gaps = 104/337 (30%) Query: 88 IASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGD 147 ++S+ + + + +G D R WDL + + + PI V + + L+ Sbjct: 106 VSSLDVGDGSKHIISGSYDGIVRTWDLSGNVQK--QYSGHSGPIRAVK-YISNTRLVSAG 162 Query: 148 QSGAIHIW-----------------------DLKTDHNEQLIPEPEVSITSAHIDPDASY 184 + +W +++ ++ + + S + D S Sbjct: 163 NDRTLRLWKTKNDDLKLTSQQQAQEDDDDEVNIEDGKTLAILEGHKAPVVSIDVS-DNSR 221 Query: 185 MAAVNSTGNCYVWNLTGGIGD------------------------------EVTQLIPKT 214 + + + + W+ + + P + Sbjct: 222 ILSASYDNSIGFWSTIYKEMTVVDPLEDINNPNNKISTAARKRRKLTMKDGTIRRRAPLS 281 Query: 215 KIPAHTRYALQCRF-SPDSTLLATCSADQTCKIWRTSNFSLMTELSIK------------ 261 + +HT Q F S D+T+ + S D T K W + + Sbjct: 282 LLESHTAPVEQVIFDSTDNTVGYSVSQDHTIKTWDLVTARCIDTRTTSYSLLSIAQLSTL 341 Query: 262 -------------------------SGNPGESSRGWMWGCAFSGDSQYI-VTASSDNLAR 295 + + ++ +++YI + S D + Sbjct: 342 NLLACGSSARHITLHDPRVGASSKVTQQQLIGHKNFVSSLDTCPENEYILCSGSHDGTVK 401 Query: 296 LWCVE--------TGEIKREYGGHQKAVVCLAFNDSV 324 +W V T E K G V + + + V Sbjct: 402 VWDVRSTSPMYTITREDKSVQKGVNDKVFAVKWAEKV 438 Score = 83.3 bits (204), Expect = 2e-16, Method: Composition-based stats. Identities = 29/167 (17%), Positives = 65/167 (38%), Gaps = 15/167 (8%) Query: 2 NTSPGTV----GSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMI 57 +T+P +D + + DHT++ W + C T S ++ +++ + Sbjct: 286 HTAPVEQVIFDSTDNTVGYSVSQDHTIKTWDLVTARCIDTRTTSYSLLSIAQLSTLNLLA 345 Query: 58 AAAGYQHIRMYD--LNSNNPNPIISYDGVNKNIASVGFHEDGRW-MYTGGEDCTARIWDL 114 + +HI ++D + +++ G ++S+ + + + +G D T ++WD+ Sbjct: 346 CGSSARHITLHDPRVGASSKVTQQQLIGHKNFVSSLDTCPENEYILCSGSHDGTVKVWDV 405 Query: 115 RSRNLQCQRI-------FQVNAPINCVCLHPNQAELIVGDQSGAIHI 154 RS + VN + V + +I Q I I Sbjct: 406 RSTSPMYTITREDKSVQKGVNDKVFAVKW-AEKVGIISAGQDKKIQI 451 Score = 70.9 bits (172), Expect = 7e-13, Method: Composition-based stats. Identities = 27/231 (11%), Positives = 64/231 (27%), Gaps = 49/231 (21%) Query: 123 RIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDA 182 F ++ + + +I G G + WDL + + ++ I + + Sbjct: 98 NSFSNEDWVSSLDVGDGSKHIISGSYDGIVRTWDL-SGNVQKQYSGHSGPIRAVKYISN- 155 Query: 183 SYMAAVNSTGNCYVWNLTGGIGDEVTQLIPK---------------TKIPAHTRYALQCR 227 + + + + +W +Q + + H + Sbjct: 156 TRLVSAGNDRTLRLWKTKNDDLKLTSQQQAQEDDDDEVNIEDGKTLAILEGHKAPVVSID 215 Query: 228 FSPDSTLLATCSADQTCKIWRTSNFSL----------------------MTELSIKSG-- 263 S D++ + + S D + W T + +L++K G Sbjct: 216 VS-DNSRILSASYDNSIGFWSTIYKEMTVVDPLEDINNPNNKISTAARKRRKLTMKDGTI 274 Query: 264 ------NPGESSRGWMWGCAFSGDSQYI-VTASSDNLARLWCVETGEIKRE 307 + ES + F + + S D+ + W + T Sbjct: 275 RRRAPLSLLESHTAPVEQVIFDSTDNTVGYSVSQDHTIKTWDLVTARCIDT 325 Score = 44.0 bits (102), Expect = 1e-04, Method: Composition-based stats. Identities = 12/53 (22%), Positives = 27/53 (50%), Gaps = 1/53 (1%) Query: 268 SSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAF 320 S+ W+ S++I++ S D + R W + G ++++Y GH + + + Sbjct: 101 SNEDWVSSLDVGDGSKHIISGSYDGIVRTWDLS-GNVQKQYSGHSGPIRAVKY 152 >3CFV-B nrPDB Length = 414 Score = 118 bits (296), Expect = 3e-27, Method: Composition-based stats. Identities = 45/273 (16%), Positives = 99/273 (36%), Gaps = 30/273 (10%) Query: 8 VGSDPVILATAGYDHTVRFWQA--------HSGIC--TRTVQHQDSQVNALEVTPD--RS 55 + +P I+AT V + SG C ++ + L + Sbjct: 135 MPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGYGLSWNSNLSGH 194 Query: 56 MIAAAGYQHIRMYDLNSN-NPNPIIS----YDGVNKNIASVGFHEDGRWMY-TGGEDCTA 109 +++A+ + ++D+N+ I+ + G + + V +H ++ + +D Sbjct: 195 LLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESLFGSVADDQKL 254 Query: 110 RIWDLRSRNL--QCQRIFQVNAPINCVCLHP-NQAELIVGDQSGAIHIWDLKTDH-NEQL 165 IWD RS + A +NC+ +P ++ L G + +WDL+ Sbjct: 255 MIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHT 314 Query: 166 IPEPEVSITSAHIDP-DASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIP------A 218 + I H P + + +A+ + VW+L+ ++ + Sbjct: 315 FESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGG 374 Query: 219 HTRYALQCRFSPDSTL-LATCSADQTCKIWRTS 250 HT ++P+ + + S D +IW+ + Sbjct: 375 HTAKISDFSWNPNEPWVICSVSEDNIMQIWQMA 407 Score = 113 bits (282), Expect = 1e-25, Method: Composition-based stats. Identities = 42/291 (14%), Positives = 100/291 (34%), Gaps = 37/291 (12%) Query: 40 HQDSQVNALEVTPDRSMIAAAG--YQHIRMYDLN--------SNNPNPIISYDGVNKNIA 89 + + +VN P I A + ++D S NP + G K Sbjct: 124 NHEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGY 183 Query: 90 SVGFHED-GRWMYTGGEDCTARIWDLRSRNLQCQRI------FQVNAPINCVCLH-PNQA 141 + ++ + + + +D T +WD+ + + + + +A + V H +++ Sbjct: 184 GLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHES 243 Query: 142 ELIVGDQSGAIHIWDLKTD---HNEQLIPEPEVSITSAHIDPDASY-MAAVNSTGNCYVW 197 + IWD +++ L+ + +P + + +A ++ +W Sbjct: 244 LFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALW 303 Query: 198 NLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDS-TLLATCSADQTCKIWRTSNFSLMT 256 +L T +H Q +SP + T+LA+ D+ +W S Sbjct: 304 DLRNLKLKLHT-------FESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQ 356 Query: 257 ELS------IKSGNPGESSRGWMWGCAFSGDSQY-IVTASSDNLARLWCVE 300 + + +++ + + I + S DN+ ++W + Sbjct: 357 SAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMA 407 Score = 91.0 bits (224), Expect = 6e-19, Method: Composition-based stats. Identities = 38/276 (13%), Positives = 81/276 (29%), Gaps = 47/276 (17%) Query: 84 VNKNIASVGFHEDG-RWMYTGGEDCTARIWDL------RSRNLQC---QRIFQVNAPINC 133 + + + T ++D + +C R+ Sbjct: 125 HEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGYG 184 Query: 134 VCLHPN-QAELIVGDQSGAIHIWDLKTDHNEQ-------LIPEPEVSITSAHIDPD-ASY 184 + + N L+ + +WD+ E + + S Sbjct: 185 LSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESL 244 Query: 185 MAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLL-ATCSADQT 243 +V +W+ + P + AHT F+P S + AT SAD+T Sbjct: 245 FGSVADDQKLMIWDTRSNTTSK-----PSHLVDAHTAEVNCLSFNPYSEFILATGSADKT 299 Query: 244 CKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSG-DSQYIVTASSDNLARLWCVET- 301 +W N L + ES + ++ +S + + ++ +D +W + Sbjct: 300 VALWDLRNLKLKL-------HTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKI 352 Query: 302 -------------GEIKREYGGHQKAVVCLAFNDSV 324 E+ +GGH + ++N + Sbjct: 353 GEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNE 388 >5Y1U-A nrPDB Length = 456 Score = 118 bits (296), Expect = 3e-27, Method: Composition-based stats. Identities = 44/273 (16%), Positives = 98/273 (35%), Gaps = 30/273 (10%) Query: 8 VGSDPVILATAGYDHTVRFWQA--------HSGIC--TRTVQHQDSQVNALEVTPD--RS 55 + +P I+AT V + SG C ++ + L P+ Sbjct: 164 MPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGH 223 Query: 56 MIAAAGYQHIRMYDLNS----NNPNPIIS-YDGVNKNIASVGFHEDGRWMY-TGGEDCTA 109 +++A+ I ++D+++ + + G + V +H ++ + +D Sbjct: 224 LLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKL 283 Query: 110 RIWDLRSRNL--QCQRIFQVNAPINCVCLHP-NQAELIVGDQSGAIHIWDLKTDH-NEQL 165 IWD RS N + A +NC+ +P ++ L G + +WDL+ Sbjct: 284 MIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHS 343 Query: 166 IPEPEVSITSAHIDP-DASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIP------A 218 + I P + + +A+ + VW+L+ ++ + Sbjct: 344 FESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGG 403 Query: 219 HTRYALQCRFSPDSTL-LATCSADQTCKIWRTS 250 HT ++P+ + + S D ++W+ + Sbjct: 404 HTAKISDFSWNPNEPWVICSVSEDNIMQVWQMA 436 Score = 114 bits (284), Expect = 7e-26, Method: Composition-based stats. Identities = 44/291 (15%), Positives = 103/291 (35%), Gaps = 37/291 (12%) Query: 40 HQDSQVNALEVTPDRSMIAAAG--YQHIRMYDLN--------SNNPNPIISYDGVNKNIA 89 + + +VN P I A + ++D S NP + G K Sbjct: 153 NHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGY 212 Query: 90 SVGFHED-GRWMYTGGEDCTARIWDL-----RSRNLQCQRIF-QVNAPINCVCLH-PNQA 141 + ++ + + + +D T +WD+ + + + IF A + V H +++ Sbjct: 213 GLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHES 272 Query: 142 ELIVGDQSGAIHIWDLKTD---HNEQLIPEPEVSITSAHIDPDASY-MAAVNSTGNCYVW 197 + IWD +++ + + +P + + +A ++ +W Sbjct: 273 LFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALW 332 Query: 198 NLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDS-TLLATCSADQTCKIWRTSN-FSLM 255 +L + +H Q ++SP + T+LA+ D+ +W S Sbjct: 333 DLRNLKLKLHS-------FESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQ 385 Query: 256 TELSIKSGNP-----GESSRGWMWGCAFSGDSQY-IVTASSDNLARLWCVE 300 + + G P + +++ + + I + S DN+ ++W + Sbjct: 386 SPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMA 436 Score = 91.7 bits (226), Expect = 4e-19, Method: Composition-based stats. Identities = 40/276 (14%), Positives = 82/276 (29%), Gaps = 47/276 (17%) Query: 84 VNKNIASVGFHEDGR-WMYTGGEDCTARIWDL------RSRNLQC---QRIFQVNAPINC 133 + + + T ++D + +C R+ Sbjct: 154 HEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYG 213 Query: 134 VCLHPN-QAELIVGDQSGAIHIWDLKTDHNE-------QLIPEPEVSITSAHIDPD-ASY 184 + +PN L+ I +WD+ E + + S Sbjct: 214 LSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESL 273 Query: 185 MAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLL-ATCSADQT 243 +V +W+ + P + AHT F+P S + AT SAD+T Sbjct: 274 FGSVADDQKLMIWDTRSNNTSK-----PSHSVDAHTAEVNCLSFNPYSEFILATGSADKT 328 Query: 244 CKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSG-DSQYIVTASSDNLARLWCVET- 301 +W N L + ES + ++ +S + + ++ +D +W + Sbjct: 329 VALWDLRNLKLKL-------HSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKI 381 Query: 302 -------------GEIKREYGGHQKAVVCLAFNDSV 324 E+ +GGH + ++N + Sbjct: 382 GEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNE 417 >3JRP-A nrPDB Length = 379 Score = 114 bits (285), Expect = 5e-26, Method: Composition-based stats. Identities = 42/281 (14%), Positives = 91/281 (32%), Gaps = 31/281 (11%) Query: 41 QDSQVNALEVTPDRSMIAAAGYQ-HIRMYDLNSNNPNPIISYDGVNKNIASVGFHED--G 97 + ++ + +A I+++++ I + G + V + G Sbjct: 10 HNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFG 69 Query: 98 RWMYTGGEDCTARIWDLRSRNLQCQRIF-QVNAPINCVCLHPN--QAELIVGDQSGAIHI 154 + + D IW + + +A +N V P+ L+V G + + Sbjct: 70 TILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSV 129 Query: 155 WDLKTDHNEQ--LIPEPEVSITSAHIDP-------------DASYMAAVNSTGNCYVWNL 199 + K + +I + + SA P ++ + +W Sbjct: 130 VEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKY 189 Query: 200 TGGIGDEVTQLIPKTKIPAHTRYALQCRFSPD---STLLATCSADQTCKIWRTSNFSLMT 256 V ++ + H+ + +SP + LA+ S D+TC IW N Sbjct: 190 NSDAQTYVL----ESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPW 245 Query: 257 ELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLW 297 + ++ E +W ++S + + DN LW Sbjct: 246 KKTLL---KEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 283 Score = 110 bits (275), Expect = 7e-25, Method: Composition-based stats. Identities = 42/262 (16%), Positives = 88/262 (33%), Gaps = 31/262 (11%) Query: 15 LATAGYDHTVRFWQA--HSGICTRTVQHQDSQVNALEV--TPDRSMIAAAGYQ-HIRMYD 69 LAT D T++ ++ + T+ + V ++ +++A+ Y + ++ Sbjct: 26 LATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWK 85 Query: 70 LNSNNPNPIISYDGVNKNIASVGF--HEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQV 127 + + I + + ++ SV + HE G + D + + + I Sbjct: 86 EENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDA 145 Query: 128 NAP-INCVCLHP-------------NQAELIVGDQSGAIHIW----DLKTDHNEQLIPEP 169 +A +N P + + G + IW D +T E + Sbjct: 146 HAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGH 205 Query: 170 EVSITSAHIDPD---ASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQC 226 + P SY+A+V+ C +W G L+ + K P + Sbjct: 206 SDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDV---LWRA 262 Query: 227 RFSPDSTLLATCSADQTCKIWR 248 +S +LA D +W+ Sbjct: 263 SWSLSGNVLALSGGDNKVTLWK 284 Score = 89.8 bits (221), Expect = 1e-18, Method: Composition-based stats. Identities = 33/203 (16%), Positives = 69/203 (33%), Gaps = 23/203 (11%) Query: 140 QAELIVGDQSGAIHIWDLK--TDHNEQLIPEPEVSITSAHIDP--DASYMAAVNSTGNCY 195 L I I++++ T + E + + +A+ + G Sbjct: 23 GKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVL 82 Query: 196 VWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPD--STLLATCSADQTCKIWRTSNFS 253 +W G ++ H+ +++P LL S+D + Sbjct: 83 IWKEENGRWSQI------AVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENG 136 Query: 254 LMTELSIKSGNPGESSRGWMWGCAF-------SGDSQYIVTASSDNLARLW----CVETG 302 + + I + G +S W + +S+ VT +DNL ++W +T Sbjct: 137 TTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTY 196 Query: 303 EIKREYGGHQKAVVCLAFNDSVL 325 ++ GH V +A++ +VL Sbjct: 197 VLESTLEGHSDWVRDVAWSPTVL 219 Score = 85.6 bits (210), Expect = 3e-17, Method: Composition-based stats. Identities = 36/215 (16%), Positives = 69/215 (32%), Gaps = 29/215 (13%) Query: 12 PVILATAGYDHTVRFWQAHSGICTRTVQH--QDSQVNALEVTP---DRSMIAAAGYQHIR 66 ILA+ YD V W+ +G ++ H + VN+++ P ++ A+ + Sbjct: 69 GTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVS 128 Query: 67 MYDLNSNNPNPIISYDGVNKNIASVGFHE-------------DGRWMYTGGEDCTARIWD 113 + + N I D + S + + R TGG D +IW Sbjct: 129 VVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWK 188 Query: 114 LRSRNLQC---QRIFQVNAPINCVCLHPN---QAELIVGDQSGAIHIW--DLKTDHNEQL 165 S + + + V P ++ L Q IW D + ++ Sbjct: 189 YNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKT 248 Query: 166 IPEPEVS---ITSAHIDPDASYMAAVNSTGNCYVW 197 + + E + A + +A +W Sbjct: 249 LLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 283 Score = 55.9 bits (133), Expect = 2e-08, Method: Composition-based stats. Identities = 22/114 (19%), Positives = 37/114 (32%), Gaps = 10/114 (8%) Query: 217 PAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGC 276 AH LATCS+D+T KI+ + K + G +W Sbjct: 8 NAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGE------THKLIDTLTGHEGPVWRV 61 Query: 277 AFS--GDSQYIVTASSDNLARLWCVETGE--IKREYGGHQKAVVCLAFNDSVLG 326 ++ + + S D +W E G + H +V + + G Sbjct: 62 DWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYG 115 Score = 54.8 bits (130), Expect = 5e-08, Method: Composition-based stats. Identities = 17/128 (13%), Positives = 40/128 (31%), Gaps = 19/128 (14%) Query: 4 SPGTVGSDPV--------ILATAGYDHTVRFW----QAHSGICTRTVQHQDSQVNALEVT 51 +P T+ D T G D+ V+ W A + + T++ V + + Sbjct: 156 APATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWS 215 Query: 52 P----DRSMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKN---IASVGFHEDGRWMYTGG 104 P + + + + ++ ++ + K + + G + G Sbjct: 216 PTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSG 275 Query: 105 EDCTARIW 112 D +W Sbjct: 276 GDNKVTLW 283 >5K0Y-T nrPDB Length = 329 Score = 114 bits (285), Expect = 6e-26, Method: Composition-based stats. Identities = 47/311 (15%), Positives = 101/311 (32%), Gaps = 47/311 (15%) Query: 38 VQHQDSQVNALEVTPDRSMIAAAGYQHI-RMYDLNSNNPNPIISYDGVNKNIASVGFHED 96 +Q + + ++ + ++ I ++ S N + +Y G + V D Sbjct: 6 LQGHERSITQIKYNREGDLLFTVAKDPIVNVW--YSVNGERLGTYMGHTGAVWCVDADWD 63 Query: 97 GRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVG-----DQSGA 151 + + TG D + R+WD + + + + N+ + ++ Sbjct: 64 TKHVLTGSADNSCRLWDCETG--KQLALLKTNSAVRTCGFDFGGNIIMFSTDKQMGYQCF 121 Query: 152 IHIWDLK------TDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGD 205 + +DL+ + IP + ITSA P + A + +G ++ G Sbjct: 122 VSFFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSG--- 178 Query: 206 EVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNP 265 + H+R + S + T+ T S D T K++ ++ + Sbjct: 179 -----EVLVNVKEHSRQINDIQLSREMTMFVTASKDNTAKLFDSTTLEHQKTFRTEPPRE 233 Query: 266 GESSRGWMWGCAFSGDSQYIVTASS----DNL----------ARLWCVETGEIKREYGGH 311 A S + +++V D AR + + E GH Sbjct: 234 LA---------ALSPNYEHVVVGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGH 284 Query: 312 QKAVVCLAFND 322 + +AF+ Sbjct: 285 FGPINSVAFHP 295 Score = 104 bits (259), Expect = 6e-23, Method: Composition-based stats. Identities = 44/305 (14%), Positives = 94/305 (30%), Gaps = 29/305 (9%) Query: 9 GSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQH-IRM 67 + +L T D V W + +G T V ++ D + + R+ Sbjct: 19 NREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTKHVLTGSADNSCRL 78 Query: 68 YDLNSNNPNPIISYDGVNKNIASVGFHEDGRWM-YTG----GEDCTARIWDLRSR----- 117 +D + ++ N + + GF G + ++ G C +DLR Sbjct: 79 WDCETGKQLALLKT---NSAVRTCGFDFGGNIIMFSTDKQMGYQCFVSFFDLRDPSQIDN 135 Query: 118 NLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAH 177 N +I ++ I P +I G +SG ++ + K+ + E I Sbjct: 136 NEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEVLVNVKEHSRQINDIQ 195 Query: 178 IDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLAT 237 + + + + +++ T + + P ++ SP+ + Sbjct: 196 LSREMTMFVTASKDNTAKLFDSTTLEHQKTFRTEPPRELA---------ALSPNYEHVVV 246 Query: 238 CSADQTCKIWRTSNFSLMTELSI------KSGNPGESSRGWMWGCAFSGDSQYIVTASSD 291 + + TS E + + G + AF D + + D Sbjct: 247 GGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHPDGKSYSSGGED 306 Query: 292 NLARL 296 R+ Sbjct: 307 GYVRI 311 Score = 67.5 bits (163), Expect = 7e-12, Method: Composition-based stats. Identities = 19/200 (9%), Positives = 55/200 (27%), Gaps = 6/200 (3%) Query: 126 QVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYM 185 I + + L + +++W ++ D D ++ Sbjct: 8 GHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTKHV 67 Query: 186 AAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCK 245 ++ +C +W+ G + + + FS D + C Sbjct: 68 LTGSADNSCRLWDCETGKQLALLKTNSAVRTCGFDFGGNIIMFSTDKQMGYQC----FVS 123 Query: 246 IWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIK 305 + + S + P S+ + + + I+ + ++GE+ Sbjct: 124 FFDLRDPSQIDNNEPYMKIPCNDSK--ITSAVWGPLGECIIAGHESGELNQYSAKSGEVL 181 Query: 306 REYGGHQKAVVCLAFNDSVL 325 H + + + + + Sbjct: 182 VNVKEHSRQINDIQLSREMT 201 Score = 65.6 bits (158), Expect = 3e-11, Method: Composition-based stats. Identities = 24/119 (20%), Positives = 34/119 (28%), Gaps = 8/119 (6%) Query: 165 LIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYAL 224 L+ E SIT + + + V VW G HT Sbjct: 5 LLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYM--------GHTGAVW 56 Query: 225 QCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQ 283 D+ + T SAD +C++W + L S FS D Q Sbjct: 57 CVDADWDTKHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGFDFGGNIIMFSTDKQ 115 Score = 52.8 bits (125), Expect = 2e-07, Method: Composition-based stats. Identities = 23/118 (19%), Positives = 42/118 (35%), Gaps = 14/118 (11%) Query: 7 TVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQH-- 64 + + + TA D+T + + + + +T + + ++P+ + G Q Sbjct: 195 QLSREMTMFVTASKDNTAKLFDSTTLEHQKTFRT-EPPRELAALSPNYEHVVVGGGQEAM 253 Query: 65 ------IRMYDLNSN-----NPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARI 111 R+ + G I SV FH DG+ +GGED RI Sbjct: 254 DVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHPDGKSYSSGGEDGYVRI 311 >5OQL-L nrPDB Length = 557 Score = 114 bits (284), Expect = 7e-26, Method: Composition-based stats. Identities = 45/295 (15%), Positives = 101/295 (34%), Gaps = 23/295 (7%) Query: 1 MNTSPGTVGSDPVILA-TAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAA 59 +++S + A TAG V + +T+ DS+ + E+ PD ++ A Sbjct: 59 VSSSLVAAAKTNDLFAVTAGP--RVEIFSIRKREPLKTIGRFDSEAHCGEIRPDGRVLVA 116 Query: 60 AGY-QHIRMYDLNSNNP-NPIISYDGVNKNIASVGFHE-DGRWMYTGGEDCTARIWDLRS 116 ++++D+ + ++ + + + + + + +D T R+WDL S Sbjct: 117 GEDTGRMQVFDVGQGTRAVILKTWHIHKQPVWVTKWSPTELTTLMSCSDDKTVRLWDLPS 176 Query: 117 RNLQCQRIFQVNAPINCVCLHP---NQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSI 173 N + + C P N L+ G + +WD + + + I Sbjct: 177 -NDPTRLFTGHTDYVRCGAFMPGSANSNLLVSGSYDETVRVWDARAPGGAVMTFKHADPI 235 Query: 174 TSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDST 233 P + + A + V +L P I H + + Sbjct: 236 EDVLPLPSGTTLLAASG-NAISVLDLVAAK--------PLRLITNHQKTVTSLSLASQGR 286 Query: 234 LLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTA 288 + + S D K++ T++++++ S S + S D +++ Sbjct: 287 RVVSGSLDGHVKVFETTSWNVVAGAKYPSPILSLS----VITAGASHDDRHLAVG 337 Score = 107 bits (267), Expect = 7e-24, Method: Composition-based stats. Identities = 32/266 (12%), Positives = 77/266 (28%), Gaps = 30/266 (11%) Query: 48 LEVTPDRSMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDC 107 + + A + ++ + P I + DGR + G + Sbjct: 64 VAAAKTNDLFAVTAGPRVEIFSIRKREPLKTIGR--FDSEAHCGEIRPDGRVLVAGEDTG 121 Query: 108 TARIWDLRSRNLQCQRI--FQVNAPINCVCLHPNQ-AELIVGDQSGAIHIWDLKTDHNEQ 164 +++D+ P+ P + L+ + +WDL ++ + Sbjct: 122 RMQVFDVGQGTRAVILKTWHIHKQPVWVTKWSPTELTTLMSCSDDKTVRLWDLPSNDPTR 181 Query: 165 LIPEPEVSITSAHI---DPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTR 221 L + +++ + + + VW+ G +T H Sbjct: 182 LFTGHTDYVRCGAFMPGSANSNLLVSGSYDETVRVWDARAPGGAVMTFK--------HAD 233 Query: 222 YALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGD 281 P T L S + S++ ++ K + + + + + Sbjct: 234 PIEDVLPLPSGTTLLAASGNAI---------SVLDLVAAKPLRLITNHQKTVTSLSLASQ 284 Query: 282 SQYIVTASSDNLARL-----WCVETG 302 + +V+ S D ++ W V G Sbjct: 285 GRRVVSGSLDGHVKVFETTSWNVVAG 310 Score = 85.6 bits (210), Expect = 3e-17, Method: Composition-based stats. Identities = 29/197 (14%), Positives = 64/197 (32%), Gaps = 12/197 (6%) Query: 8 VGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTP---DRSMIAAAGYQ- 63 ++ L + D TVR W S TR V P + +++ + Y Sbjct: 153 SPTELTTLMSCSDDKTVRLWDLPSNDPTRLFTGHTDYVRCGAFMPGSANSNLLVSGSYDE 212 Query: 64 HIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQR 123 +R++D + ++++ I V G + + DL + Sbjct: 213 TVRVWDARA-PGGAVMTFK-HADPIEDVLPLPSGTTLLAAS-GNAISVLDL-VAAKPLRL 268 Query: 124 IFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEV----SITSAHID 179 I + + L ++ G G + +++ + + P S+ +A Sbjct: 269 ITNHQKTVTSLSLASQGRRVVSGSLDGHVKVFETTSWNVVAGAKYPSPILSLSVITAGAS 328 Query: 180 PDASYMAAVNSTGNCYV 196 D ++A +G + Sbjct: 329 HDDRHLAVGMQSGVLSI 345 Score = 84.8 bits (208), Expect = 4e-17, Method: Composition-based stats. Identities = 38/226 (16%), Positives = 76/226 (33%), Gaps = 35/226 (15%) Query: 114 LRSRNLQCQRIFQVNAPINCVCLHPN-------QAELIVGDQSGA---------IHIWDL 157 RS Q N PI+ + + + L+ ++ + I+ + Sbjct: 27 WRSFKKQKSHTSTANWPISHISFPASLGTTALVSSSLVAAAKTNDLFAVTAGPRVEIFSI 86 Query: 158 KTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIP 217 + + I + I PD + A TG V+++ G + + Sbjct: 87 RKREPLKTIGRFDSEAHCGEIRPDGRVLVAGEDTGRMQVFDVGQGTRAVILK-----TWH 141 Query: 218 AHTRYALQCRFSPDS-TLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGC 276 H + ++SP T L +CS D+T ++W + + + ++ Sbjct: 142 IHKQPVWVTKWSPTELTTLMSCSDDKTVRLWDLPSNDPTRLFTGHT--------DYVRCG 193 Query: 277 AF---SGDSQYIVTASSDNLARLWCVET-GEIKREYGGHQKAVVCL 318 AF S +S +V+ S D R+W G + H + + Sbjct: 194 AFMPGSANSNLLVSGSYDETVRVWDARAPGGAVMTFK-HADPIEDV 238 Score = 64.0 bits (154), Expect = 9e-11, Method: Composition-based stats. Identities = 31/195 (15%), Positives = 57/195 (29%), Gaps = 21/195 (10%) Query: 138 PNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDP---------DASYMAAV 188 P+ I +Q W ++ ++ S P +S +AA Sbjct: 14 PSGPSPITAEQ----RYW--RSFKKQKSHTSTANWPISHISFPASLGTTALVSSSLVAAA 67 Query: 189 NSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWR 248 + V + + P I A PD +L +++ Sbjct: 68 KTNDLFAVTAGPRVEIFSIRKREPLKTIGRFDSEAHCGEIRPDGRVLVAGEDTGRMQVFD 127 Query: 249 TSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDS-QYIVTASSDNLARLWCVETGEIKRE 307 + L + +W +S +++ S D RLW + + + R Sbjct: 128 VGQGTRAVILK-----TWHIHKQPVWVTKWSPTELTTLMSCSDDKTVRLWDLPSNDPTRL 182 Query: 308 YGGHQKAVVCLAFND 322 + GH V C AF Sbjct: 183 FTGHTDYVRCGAFMP 197 >4XYI-A nrPDB Length = 430 Score = 114 bits (284), Expect = 7e-26, Method: Composition-based stats. Identities = 47/272 (17%), Positives = 95/272 (34%), Gaps = 31/272 (11%) Query: 8 VGSDPVILATAGYDHTVRFWQAHSGICT--------RTVQHQDSQVNAL--EVTPDRSMI 57 + +P I+AT G + + + ++H S+ L + ++ Sbjct: 140 MPQNPDIIATLGLNGNGYIFDLNLYREQPIVQTGHQACLRHHTSEGFGLGWNFIQEGTLA 199 Query: 58 AAAGYQHIRMYDLN--------SNNPNPIISYDGVNKNIASVGFHEDGRWMYTG-GEDCT 108 I ++D+ S + P+ Y + + FH + T +DCT Sbjct: 200 TGTEDTSICVWDIKGKSLSLEKSIDVAPVSVYHRHTAVVNDLQFHLQHEALLTSVSDDCT 259 Query: 109 ARIWDLR--SRNLQCQRIFQVNAPINCVCLHP-NQAELIVGDQSGAIHIWDLKT-DHNEQ 164 +I D R S + Q + P+N V +P N L + +WDL+ + Sbjct: 260 LQIHDTRLPSSSSASQCVKAHEQPVNGVAFNPFNDYLLATASADHTVALWDLRRLNQRLH 319 Query: 165 LIPEPEVSITSAHIDP-DASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIP------ 217 + E + + P D + ++ VW+L+ ++ + Sbjct: 320 TLEGHEDEVYNVQWSPHDEPILVTSSTDRRVCVWDLSKIGEEQTVEDSEDGAPELMFMHG 379 Query: 218 AHTRYALQCRFSPDSTL-LATCSADQTCKIWR 248 HT ++P++ LA+ + D +IW Sbjct: 380 GHTNRVSDLSWNPNNKWVLASLADDNILQIWS 411 Score = 105 bits (262), Expect = 2e-23, Method: Composition-based stats. Identities = 47/293 (16%), Positives = 103/293 (35%), Gaps = 40/293 (13%) Query: 40 HQDSQVNALEVTPDRSMIAA--AGYQHIRMYDLNSNNPNPIIS------YDGVNKNIASV 91 H + VN P I A + ++DLN PI+ + Sbjct: 129 HHEGDVNKARFMPQNPDIIATLGLNGNGYIFDLNLYREQPIVQTGHQACLRHHTSEGFGL 188 Query: 92 GFH--EDGRWMYTGGEDCTARIWDLRSRNL---------QCQRIFQVNAPINCVCLH-PN 139 G++ ++G + TG ED + +WD++ ++L + A +N + H + Sbjct: 189 GWNFIQEGT-LATGTEDTSICVWDIKGKSLSLEKSIDVAPVSVYHRHTAVVNDLQFHLQH 247 Query: 140 QAELIVGDQSGAIHIWDLK---TDHNEQLIPEPEVSITSAHIDP-DASYMAAVNSTGNCY 195 +A L + I D + + Q + E + +P + +A ++ Sbjct: 248 EALLTSVSDDCTLQIHDTRLPSSSSASQCVKAHEQPVNGVAFNPFNDYLLATASADHTVA 307 Query: 196 VWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSP-DSTLLATCSADQTCKIWRTSNFSL 254 +W+L T + H ++SP D +L T S D+ +W S Sbjct: 308 LWDLRRLNQRLHT-------LEGHEDEVYNVQWSPHDEPILVTSSTDRRVCVWDLSKIGE 360 Query: 255 MTELS------IKSGNPGESSRGWMWGCAFSGDSQY-IVTASSDNLARLWCVE 300 + + + +++ ++++ + + + DN+ ++W Sbjct: 361 EQTVEDSEDGAPELMFMHGGHTNRVSDLSWNPNNKWVLASLADDNILQIWSPS 413 Score = 91.7 bits (226), Expect = 4e-19, Method: Composition-based stats. Identities = 33/233 (14%), Positives = 71/233 (30%), Gaps = 30/233 (12%) Query: 15 LATAGYDHTVRFWQAHSGIC----------TRTVQHQDSQVNALEVTPDRSMIAAAGYQH 64 LAT D ++ W + VN L+ + + Sbjct: 198 LATGTEDTSICVWDIKGKSLSLEKSIDVAPVSVYHRHTAVVNDLQFHLQHEALLTSVSDD 257 Query: 65 IRMYDLNSNNPNPIIS---YDGVNKNIASVGFHEDGRWM-YTGGEDCTARIWDLRSRNLQ 120 + ++ P+ + + + V F+ ++ T D T +WDLR N + Sbjct: 258 CTLQIHDTRLPSSSSASQCVKAHEQPVNGVAFNPFNDYLLATASADHTVALWDLRRLNQR 317 Query: 121 CQRIFQVNAPINCVCLHP-NQAELIVGDQSGAIHIWDLKTDHNEQLIP------------ 167 + + V P ++ L+ + +WDL EQ + Sbjct: 318 LHTLEGHEDEVYNVQWSPHDEPILVTSSTDRRVCVWDLSKIGEEQTVEDSEDGAPELMFM 377 Query: 168 --EPEVSITSAHIDPDASYMAAVNSTGNC-YVWNLTGGIGDEVTQLIPKTKIP 217 ++ +P+ ++ A + N +W+ + I + I + Sbjct: 378 HGGHTNRVSDLSWNPNNKWVLASLADDNILQIWSPSKVIWASDSLKIDSKDLE 430 Score = 87.5 bits (215), Expect = 8e-18, Method: Composition-based stats. Identities = 43/316 (13%), Positives = 97/316 (30%), Gaps = 48/316 (15%) Query: 44 QVNALEVTPDRSMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDG-RWMYT 102 QV ++++ + ++ + + I+ ++ F + T Sbjct: 90 QVASVQLPTFDDDLDDLTPSKMKPANFKGDYGLDIVQKIHHEGDVNKARFMPQNPDIIAT 149 Query: 103 GGEDCTARIWDLR-------SRNLQCQRIFQVNAPINCVCLH-PNQAELIVGDQSGAIHI 154 G + I+DL + + + + + + L G + +I + Sbjct: 150 LGLNGNGYIFDLNLYREQPIVQTGHQACLRHHTSEGFGLGWNFIQEGTLATGTEDTSICV 209 Query: 155 WDLKTD----------HNEQLIPEPEVSITSAHID-PDASYMAAVNSTGNCYVWNLTGGI 203 WD+K + + + + +V+ + + Sbjct: 210 WDIKGKSLSLEKSIDVAPVSVYHRHTAVVNDLQFHLQHEALLTSVSDDCTLQIHDTRLPS 269 Query: 204 GDEVTQLIPKTKIPAHTRYALQCRFSP-DSTLLATCSADQTCKIWRTSNFSLMTELSIKS 262 +Q + AH + F+P + LLAT SAD T +W + Sbjct: 270 SSSASQC-----VKAHEQPVNGVAFNPFNDYLLATASADHTVALWDLRRLNQRL------ 318 Query: 263 GNPGESSRGWMWGCAFSG-DSQYIVTASSDNLARLWCVETGEIKREYG------------ 309 + E ++ +S D +VT+S+D +W + ++ Sbjct: 319 -HTLEGHEDEVYNVQWSPHDEPILVTSSTDRRVCVWDLSKIGEEQTVEDSEDGAPELMFM 377 Query: 310 --GHQKAVVCLAFNDS 323 GH V L++N + Sbjct: 378 HGGHTNRVSDLSWNPN 393 >5K19-A nrPDB Length = 569 Score = 112 bits (279), Expect = 3e-25, Method: Composition-based stats. Identities = 46/222 (20%), Positives = 80/222 (36%), Gaps = 33/222 (14%) Query: 129 APINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEP----EVSITSAHIDPDA-S 183 N + L+VG +G + + D +L E + +T P + S Sbjct: 104 HDFNHLTATAESVSLLVGFSAGQVQLIDPIKKETSKLFNEERLIDKSRVTCVKWVPGSES 163 Query: 184 YMAAVNSTGNCYVWNL--TGGIGDEVTQLIPKTK-IPAHTRY-----------------A 223 +S+GN Y++N+ T G QL+ + + HT Sbjct: 164 LFLVAHSSGNMYLYNVEHTCGTTAPHYQLLKQGESFAVHTCKSKSTRNPLLKWTVGEGAL 223 Query: 224 LQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQ 283 + FSPD LA S D +++ + ++ +S G + +S D + Sbjct: 224 NEFAFSPDGKFLACVSQDGFLRVFNFDS--------VELHGTMKSYFGGLLCVCWSPDGK 275 Query: 284 YIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDSVL 325 YIVT D+L +W + GH+ V +AF+ Sbjct: 276 YIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTT 317 Score = 63.2 bits (152), Expect = 2e-10, Method: Composition-based stats. Identities = 21/190 (11%), Positives = 47/190 (24%), Gaps = 27/190 (14%) Query: 43 SQVNALEVTPDRS--MIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWM 100 S+V ++ P + A ++ +Y++ + + Sbjct: 150 SRVTCVKWVPGSESLFLVAHSSGNMYLYNVE------------HTCGTTA-----PHYQL 192 Query: 101 YTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTD 160 GE +S + +N P+ L Q G + +++ + Sbjct: 193 LKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSV 252 Query: 161 HNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHT 220 + + PD Y+ VW+ + H Sbjct: 253 ELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVD--------CRVIARGHGHK 304 Query: 221 RYALQCRFSP 230 + F P Sbjct: 305 SWVSVVAFDP 314 Score = 59.0 bits (141), Expect = 3e-09, Method: Composition-based stats. Identities = 23/166 (13%), Positives = 51/166 (30%), Gaps = 22/166 (13%) Query: 9 GSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQH-IRM 67 D LA D +R + S T++ + + +PD I G + + Sbjct: 229 SPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTV 288 Query: 68 YDLNSNNPNPIISYDGVNKNIASVGFHEDGRWM-------YTGGEDCTARIWDLR----- 115 + + I G ++ V F + ++G ++ + Sbjct: 289 WSFV--DCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFGRDRAN 346 Query: 116 -SRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTD 160 +++ +R + P++ Q + +WDL D Sbjct: 347 STQSRLSKRNSTDSRPVSVT------YRFGSVGQDTQLCLWDLTED 386 >4BZK-B nrPDB Length = 297 Score = 111 bits (278), Expect = 4e-25, Method: Composition-based stats. Identities = 42/281 (14%), Positives = 91/281 (32%), Gaps = 31/281 (11%) Query: 41 QDSQVNALEVTPDRSMIAAAGYQ-HIRMYDLNSNNPNPIISYDGVNKNIASVGFHED--G 97 + ++ + +A I+++++ I + G + V + G Sbjct: 8 HNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFG 67 Query: 98 RWMYTGGEDCTARIWDLRSRNLQCQRIF-QVNAPINCVCLHPN--QAELIVGDQSGAIHI 154 + + D IW + + +A +N V P+ L+V G + + Sbjct: 68 TILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSV 127 Query: 155 WDLKTDHNEQ--LIPEPEVSITSAHIDP-------------DASYMAAVNSTGNCYVWNL 199 + K + +I + + SA P ++ + +W Sbjct: 128 VEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKY 187 Query: 200 TGGIGDEVTQLIPKTKIPAHTRYALQCRFSPD---STLLATCSADQTCKIWRTSNFSLMT 256 V ++ + H+ + +SP + LA+ S D+TC IW N Sbjct: 188 NSDAQTYVL----ESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPW 243 Query: 257 ELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLW 297 + ++ E +W ++S + + DN LW Sbjct: 244 KKTLL---KEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 Score = 107 bits (268), Expect = 5e-24, Method: Composition-based stats. Identities = 42/262 (16%), Positives = 88/262 (33%), Gaps = 31/262 (11%) Query: 15 LATAGYDHTVRFWQA--HSGICTRTVQHQDSQVNALEV--TPDRSMIAAAGYQ-HIRMYD 69 LAT D T++ ++ + T+ + V ++ +++A+ Y + ++ Sbjct: 24 LATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWK 83 Query: 70 LNSNNPNPIISYDGVNKNIASVGF--HEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQV 127 + + I + + ++ SV + HE G + D + + + I Sbjct: 84 EENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDA 143 Query: 128 NAP-INCVCLHP-------------NQAELIVGDQSGAIHIW----DLKTDHNEQLIPEP 169 +A +N P + + G + IW D +T E + Sbjct: 144 HAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGH 203 Query: 170 EVSITSAHIDPD---ASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQC 226 + P SY+A+V+ C +W G L+ + K P + Sbjct: 204 SDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDV---LWRA 260 Query: 227 RFSPDSTLLATCSADQTCKIWR 248 +S +LA D +W+ Sbjct: 261 SWSLSGNVLALSGGDNKVTLWK 282 Score = 87.9 bits (216), Expect = 6e-18, Method: Composition-based stats. Identities = 33/203 (16%), Positives = 69/203 (33%), Gaps = 23/203 (11%) Query: 140 QAELIVGDQSGAIHIWDLK--TDHNEQLIPEPEVSITSAHIDP--DASYMAAVNSTGNCY 195 L I I++++ T + E + + +A+ + G Sbjct: 21 GKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVL 80 Query: 196 VWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPD--STLLATCSADQTCKIWRTSNFS 253 +W G ++ H+ +++P LL S+D + Sbjct: 81 IWKEENGRWSQI------AVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENG 134 Query: 254 LMTELSIKSGNPGESSRGWMWGCAF-------SGDSQYIVTASSDNLARLW----CVETG 302 + + I + G +S W + +S+ VT +DNL ++W +T Sbjct: 135 TTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTY 194 Query: 303 EIKREYGGHQKAVVCLAFNDSVL 325 ++ GH V +A++ +VL Sbjct: 195 VLESTLEGHSDWVRDVAWSPTVL 217 Score = 83.7 bits (205), Expect = 1e-16, Method: Composition-based stats. Identities = 36/215 (16%), Positives = 69/215 (32%), Gaps = 29/215 (13%) Query: 12 PVILATAGYDHTVRFWQAHSGICTRTVQH--QDSQVNALEVTP---DRSMIAAAGYQHIR 66 ILA+ YD V W+ +G ++ H + VN+++ P ++ A+ + Sbjct: 67 GTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVS 126 Query: 67 MYDLNSNNPNPIISYDGVNKNIASVGFHE-------------DGRWMYTGGEDCTARIWD 113 + + N I D + S + + R TGG D +IW Sbjct: 127 VVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWK 186 Query: 114 LRSRNLQC---QRIFQVNAPINCVCLHPN---QAELIVGDQSGAIHIW--DLKTDHNEQL 165 S + + + V P ++ L Q IW D + ++ Sbjct: 187 YNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKT 246 Query: 166 IPEPEVS---ITSAHIDPDASYMAAVNSTGNCYVW 197 + + E + A + +A +W Sbjct: 247 LLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 Score = 54.8 bits (130), Expect = 5e-08, Method: Composition-based stats. Identities = 22/114 (19%), Positives = 37/114 (32%), Gaps = 10/114 (8%) Query: 217 PAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGC 276 AH LATCS+D+T KI+ + K + G +W Sbjct: 6 NAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGE------THKLIDTLTGHEGPVWRV 59 Query: 277 AFS--GDSQYIVTASSDNLARLWCVETGE--IKREYGGHQKAVVCLAFNDSVLG 326 ++ + + S D +W E G + H +V + + G Sbjct: 60 DWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYG 113 Score = 53.6 bits (127), Expect = 1e-07, Method: Composition-based stats. Identities = 17/128 (13%), Positives = 40/128 (31%), Gaps = 19/128 (14%) Query: 4 SPGTVGSDPV--------ILATAGYDHTVRFW----QAHSGICTRTVQHQDSQVNALEVT 51 +P T+ D T G D+ V+ W A + + T++ V + + Sbjct: 154 APATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWS 213 Query: 52 P----DRSMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKN---IASVGFHEDGRWMYTGG 104 P + + + + ++ ++ + K + + G + G Sbjct: 214 PTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSG 273 Query: 105 EDCTARIW 112 D +W Sbjct: 274 GDNKVTLW 281 >5N4A-A nrPDB Length = 771 Score = 110 bits (275), Expect = 8e-25, Method: Composition-based stats. Identities = 40/176 (22%), Positives = 72/176 (40%), Gaps = 6/176 (3%) Query: 11 DPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDL 70 D LATAG D +V+ W +G+ T+ DS V ++ D + ++ + L Sbjct: 115 DGTALATAGEDGSVKIWS-RNGMLRSTLAQADSPVYSIVWAYDCDQLCYCTGSNVVIKSL 173 Query: 71 NSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAP 130 +SN ++ + + V + + TGGEDC ++WD R L +F + P Sbjct: 174 SSNAKQN--AWKAHDGVVLKVDWSPINHLIITGGEDCKYKVWDSFGRLLFQSGLF--DYP 229 Query: 131 INCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMA 186 + V P+ VG + + D ++ SI + D++ +A Sbjct: 230 VTSVAWAPSGELFAVGGF-NTLQLCDRMGWAYSKIHLNDTGSIMTLSWTADSTQLA 284 Score = 87.1 bits (214), Expect = 8e-18, Method: Composition-based stats. Identities = 37/248 (14%), Positives = 82/248 (33%), Gaps = 30/248 (12%) Query: 84 VNKNIASVGFHEDGRWMYTGGEDCTARIWDL------RSRNLQCQRIFQVNAPINCVCLH 137 ++ A+VG++ ++T +D T W++ + L P++ Sbjct: 13 HSELTAAVGWNVWN-ELFTCSDDQTIHKWNMLGEPEQKVSTLDAYFTDMHWYPVSSKKTQ 71 Query: 138 PNQA-ELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYV 196 V G++ I +T E+ I + + S D + +A G+ + Sbjct: 72 AGGTDVFAVACTDGSVKILS-RTGRVEKSIEGHKGACISLRWSYDGTALATAGEDGSVKI 130 Query: 197 WNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMT 256 W+ + ++ + ++ D L C+ + Sbjct: 131 WS---------RNGMLRSTLAQADSPVYSIVWAYDCDQLCYCTGSNVV----------IK 171 Query: 257 ELSIKS-GNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAV 315 LS + N ++ G + +S + I+T D ++W G + + G V Sbjct: 172 SLSSNAKQNAWKAHDGVVLKVDWSPINHLIITGGEDCKYKVWD-SFGRLLFQSGLFDYPV 230 Query: 316 VCLAFNDS 323 +A+ S Sbjct: 231 TSVAWAPS 238 Score = 86.4 bits (212), Expect = 2e-17, Method: Composition-based stats. Identities = 42/282 (14%), Positives = 85/282 (30%), Gaps = 35/282 (12%) Query: 15 LATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRS----------MIAAAGYQH 64 L T D T+ W G + V D+ + P S A Sbjct: 28 LFTCSDDQTIHKWNML-GEPEQKVSTLDAYFTDMHWYPVSSKKTQAGGTDVFAVACTDGS 86 Query: 65 IRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRI 124 +++ + S +G S+ + DG + T GED + +IW R+ L+ + Sbjct: 87 VKILS-RTGRVEK--SIEGHKGACISLRWSYDGTALATAGEDGSVKIWS-RNGMLR-STL 141 Query: 125 FQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASY 184 Q ++P+ + + +L S + I L ++ + + + P Sbjct: 142 AQADSPVYSIVWAYDCDQLCYCTGSNVV-IKSLSSNAKQNAWKAHDGVVLKVDWSPINHL 200 Query: 185 MAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTC 244 + VW+ + G + L ++P L A + Sbjct: 201 IITGGEDCKYKVWD-SFGRLLFQSGLF--------DYPVTSVAWAPSGELFAVGGFN--- 248 Query: 245 KIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIV 286 L + + G + +++ DS + Sbjct: 249 ------TLQLCDRMGWAYSKIHLNDTGSIMTLSWTADSTQLA 284 >4XFV-A nrPDB Length = 792 Score = 110 bits (274), Expect = 1e-24, Method: Composition-based stats. Identities = 49/305 (16%), Positives = 97/305 (31%), Gaps = 48/305 (15%) Query: 38 VQHQDSQVNALEVTPDRSMIAAAGYQHIRMYD-LNSNNPNPIISYDGVNKNIASVGFHED 96 + Q ++ + ++A + I ++D + NN + G + V F D Sbjct: 15 FIGANKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPD 74 Query: 97 GRWMYTGGEDCTARIWDL-RSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIW 155 +M + ED +IW +LQC + Q + V L + + VG G I IW Sbjct: 75 SDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSK-TIVALSALPSLISVGCADGTISIW 133 Query: 156 --DLKTDHNEQLIPEPEVSITSAHIDP----------DASYMAAVNSTGNCYVWNLTGGI 203 +++ D E +I P +A + N ++ + Sbjct: 134 RQNIQNDEFG---LAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILS- 189 Query: 204 GDEVTQLIPKTKIPAHTRYALQCRF----SPDSTLLATCSADQTCKIWRT---------- 249 + + ++ H + F +P LL + S D+ ++WR Sbjct: 190 DSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSE 249 Query: 250 -------------SNFSLMTELSIKSGNPGE--SSRGWMWGCAFSGDSQYIVTASSDNLA 294 F + EL + W+ + ++ A++D Sbjct: 250 EDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSL 309 Query: 295 RLWCV 299 +W Sbjct: 310 MVWEP 314 Score = 94.4 bits (233), Expect = 6e-20, Method: Composition-based stats. Identities = 51/364 (14%), Positives = 113/364 (31%), Gaps = 65/364 (17%) Query: 22 HTVRFWQA---HSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQ-HIRMYDL-NSNNPN 76 T+ W ++ T++ +++V + PD + +A H++++ + ++ Sbjct: 40 KTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQ 99 Query: 77 PIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIW------DLRSRNLQCQRIFQVNAP 130 I + +K I ++ + G D T IW D + P Sbjct: 100 CIQTIQHYSKTIVALSALPS--LISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYP 157 Query: 131 INCVCLH---PNQAELIVGDQS-----GAIHIWDLKTDHNEQL--IPEPEVSITSAHI-- 178 + C+ L + L +G + + + D + + + E + S Sbjct: 158 L-CLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRH 216 Query: 179 --DPDASYMAAVNSTGNCYVW-----NLTGGIGDEVTQLI-------------------- 211 P + + + +W +L ++ +L Sbjct: 217 QETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGIN 276 Query: 212 PKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFS-------LMTELSIKSGN 264 + I H + ++ L +AD + +W S + E+S K + Sbjct: 277 FEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGAS 336 Query: 265 PGESSRGWMWGCAF--SGDSQYIVTASSDNLARLWCVE-TGEIKREY--GGHQKAVVCLA 319 S G W C + + +T R+W + + G K V +A Sbjct: 337 TATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIA 396 Query: 320 FNDS 323 ++ S Sbjct: 397 WSPS 400 Score = 87.1 bits (214), Expect = 1e-17, Method: Composition-based stats. Identities = 64/368 (17%), Positives = 107/368 (29%), Gaps = 65/368 (17%) Query: 15 LATAGYDHTVRFWQAHSGI-CTRTVQ--HQDSQVNALEVTPDRSMIAAAGYQHI------ 65 T G + R W I C + + V + +P + A Sbjct: 359 FLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAP 418 Query: 66 RMYDLNSNNPNPIISYDG------VNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNL 119 +YD S I ++ ++ V D R +GG++ R +DL Sbjct: 419 WIYD-ASGRKREIATWHEFSRPQIHGYDMICVETVTDTR-FVSGGDEKILRSFDLPKGVA 476 Query: 120 QCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIH-------------------------- 153 + F P+ A + V S Sbjct: 477 GMLQKFVG-IQFEEKSEMPDSATVPVLGLSNKAGEDDANEDDEEEEGGNKETPDITDPLS 535 Query: 154 ------IWDLKTDHNEQ----LIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGI 203 + D H + IT I PD +A+ + N N I Sbjct: 536 LLECPPMEDQLQRHLLWPEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQ--NAVIRI 593 Query: 204 GDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSG 263 L K +P H+ + +FS D L + D+ +W + EL K+ Sbjct: 594 FSTENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNE 653 Query: 264 NPGESSRGWMWGCAFSG--DSQYIVTASSDNLARLW----CVETGEIKREYGGHQKAVVC 317 P +W ++ VTAS D ++W + H KAV Sbjct: 654 KP---HTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTA 710 Query: 318 LAFNDSVL 325 ++ +DS++ Sbjct: 711 ISIHDSMI 718 Score = 84.4 bits (207), Expect = 5e-17, Method: Composition-based stats. Identities = 51/407 (12%), Positives = 106/407 (26%), Gaps = 119/407 (29%) Query: 10 SDPVILATAGYDHTVRFWQAHSG---ICTRTVQHQDSQVNALEVTP-------------- 52 D + +A DH V+ W+ C +T+QH + AL P Sbjct: 73 PDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADGTISI 132 Query: 53 ----------------------------------DRSMIAAAGYQHIRMY-------DLN 71 ++ + A G ++ ++ D Sbjct: 133 WRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSG 192 Query: 72 SNNPNPIISYDGVNKNIASVGF----HEDGRWMYTGGEDCTARIW--------------- 112 + +G + S+ F + +G +D R+W Sbjct: 193 IEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDS 252 Query: 113 -----------------DLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIW 155 +LR I + I+ + H ++ +L+ ++ +W Sbjct: 253 KKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVW 312 Query: 156 DLKTDHNEQLIPEPEVSITS-----AHIDPDAS------------YMAAVNSTGNCYVWN 198 + + ++S A + TG+ +W Sbjct: 313 EPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMW- 371 Query: 199 LTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKI---WRTSNFSLM 255 + + I T+ +SP L S DQT ++ W Sbjct: 372 ----ATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRK 427 Query: 256 TELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETG 302 E++ G+ C + V+ + + R + + G Sbjct: 428 REIATWHEFSRPQIHGYDMICVETVTDTRFVSGGDEKILRSFDLPKG 474 Score = 76.7 bits (187), Expect = 1e-14, Method: Composition-based stats. Identities = 36/191 (18%), Positives = 67/191 (35%), Gaps = 26/191 (13%) Query: 150 GAIHIWDLKTDHNEQL---IPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDE 206 I +WD +N+ + + E +T PD+ +M + + + +W T Sbjct: 40 KTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTD----- 94 Query: 207 VTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRT----SNFSLMTELSIKS 262 + L I +++ + P L++ AD T IWR F L E +IK Sbjct: 95 YSHLQCIQTIQHYSKTIVALSALPS--LISVGCADGTISIWRQNIQNDEFGLAHEFTIKK 152 Query: 263 GNPGESSRGWMWGCAFSGDSQYIVT-ASSDNLARLWC-------VETGEIKREYGGHQKA 314 G + + +Y++ ++ + +E + E GH+ Sbjct: 153 GF----FYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDW 208 Query: 315 VVCLAFNDSVL 325 V LAF Sbjct: 209 VKSLAFRHQET 219 Score = 70.6 bits (171), Expect = 1e-12, Method: Composition-based stats. Identities = 49/380 (12%), Positives = 104/380 (27%), Gaps = 76/380 (20%) Query: 15 LATAGYDHTVRFWQAHS----GICTRTV-----------QHQDSQVNALEVTPDRSM--- 56 L A D ++ W+ +C+ + + M Sbjct: 300 LLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFF 359 Query: 57 IAAAGYQHIRMYDLNSNN-PNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIW--- 112 + RM+ N + + G K++ + + G ++ D T R++ Sbjct: 360 LTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPW 419 Query: 113 --DLRSRNLQCQRIFQ------VNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQ 164 D R + + + CV + + G + +DL Sbjct: 420 IYDASGRKREIATWHEFSRPQIHGYDMICVETVTD-TRFVSGGDEKILRSFDLPKGVAGM 478 Query: 165 LIPEPEVSITSAHIDPDASYMAAVNSTGNCY--------------------VWNLTGGIG 204 L + PD++ + + + + + + Sbjct: 479 LQKFVGIQFEEKSEMPDSATVPVLGLSNKAGEDDANEDDEEEEGGNKETPDITDPLSLLE 538 Query: 205 DEVTQLIPKT--------KIPAHTRYALQCRFSPDSTLLATCSADQT-----CKIWRTSN 251 + + K+ H SPD L+A+ +I+ T N Sbjct: 539 CPPMEDQLQRHLLWPEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTEN 598 Query: 252 FSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLW--CVETGEIKREYG 309 + L IK P S + FS D +++++ D LW +E + + Sbjct: 599 W-----LEIKPALPFHSLT--ITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFK 651 Query: 310 G---HQKAVVCLAFNDSVLG 326 H + + + G Sbjct: 652 NEKPHTRIIWDADWAPLEFG 671 Score = 70.2 bits (170), Expect = 1e-12, Method: Composition-based stats. Identities = 32/192 (16%), Positives = 68/192 (35%), Gaps = 11/192 (5%) Query: 120 QCQRIFQVNAPINCVCLHPNQAELIVGDQSGA-----IHIWDLKTDHNEQ-LIPEPEVSI 173 + ++++ I C+ + P+Q + +S I I+ + + +P ++I Sbjct: 554 EVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTI 613 Query: 174 TSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPD-- 231 T D ++ +V +W + D +L K + P HTR ++P Sbjct: 614 TRLKFSKDGKFLLSVCRDRKWALW--ERNMEDNTFELRFKNEKP-HTRIIWDADWAPLEF 670 Query: 232 STLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSD 291 + T S D+T K+WR + S ++ + + I + Sbjct: 671 GNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLEN 730 Query: 292 NLARLWCVETGE 303 L+ G+ Sbjct: 731 GEIYLYSYTLGK 742 Score = 35.1 bits (79), Expect = 0.037, Method: Composition-based stats. Identities = 20/120 (16%), Positives = 41/120 (34%), Gaps = 18/120 (15%) Query: 12 PVILATAGYDHTVRFWQ-----AHSGICTRTVQHQDSQVNALEVTP----DRSMIAAA-G 61 + TA D TV+ W+ A + +++ V A+ + ++ +I+ Sbjct: 671 GNVFVTASRDKTVKVWRHQKEPADDYVLEASIK-HTKAVTAISIHDSMIREKILISVGLE 729 Query: 62 YQHIRMYDLNSNNPNPIISYDGVN---KNIASVGFHEDGR----WMYTGGEDCTARIWDL 114 I +Y I + I + + R ++ G D + RI+ L Sbjct: 730 NGEIYLYSYTLGKFELITQLNEDITPADKITRLRWSHLKRNGKLFLGVGSSDLSTRIYSL 789 >4U1E-I nrPDB Length = 347 Score = 106 bits (264), Expect = 1e-23, Method: Composition-based stats. Identities = 46/309 (14%), Positives = 102/309 (33%), Gaps = 35/309 (11%) Query: 38 VQHQDSQVNALEVTPDRSMIAAAGYQH-IRMYDLNSNNPNPIISYDGVNKNIASVGFHED 96 + + + ++ + ++ + ++ S N + + DG I S+ Sbjct: 6 LTGHERPLTQVKYNKEGDLLFSCSKDSSASVW--YSLNGERLGTLDGHTGTIWSIDVDCF 63 Query: 97 GRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQS-----GA 151 ++ TG D + ++WD+ + QC ++ P+ V P + + G+ Sbjct: 64 TKYCVTGSADYSIKLWDVSNG--QCVATWKSPVPVKRVEFSPCGNYFLAILDNVMKNPGS 121 Query: 152 IHIWDLKTD-----------HNEQLIPEPE--VSITSAHIDPDASYMAAVNSTGNCYVWN 198 I+I++++ D I E + T A Y+ A + G ++ Sbjct: 122 INIYEIERDSATHELTKVSEEPIHKIITHEGLDAATVAGWSTKGKYIIAGHKDGKISKYD 181 Query: 199 LTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTEL 258 ++ I H + +FSPD T T S D + S ++ + Sbjct: 182 VSN-------NYEYVDSIDLHEKSISDMQFSPDLTYFITSSRDTNSFLVDVSTLQVLKKY 234 Query: 259 SI--KSGNPGESSRGWMWGCAFSGDSQYIVTASSDN---LARLWCVETGEIKREYGGHQK 313 + +++ + T S++ AR + E GH Sbjct: 235 ETDCPLNTAVITPLKEFIILGGGQEAKDVTTTSANEGKFEARFYHKIFEEEIGRVQGHFG 294 Query: 314 AVVCLAFND 322 + +A + Sbjct: 295 PLNTVAISP 303 Score = 97.1 bits (240), Expect = 9e-21, Method: Composition-based stats. Identities = 37/313 (11%), Positives = 92/313 (29%), Gaps = 37/313 (11%) Query: 9 GSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQH-IRM 67 + +L + D + W + +G T+ + +++V + I++ Sbjct: 19 NKEGDLLFSCSKDSSASVWYSLNGERLGTLDGHTGTIWSIDVDCFTKYCVTGSADYSIKL 78 Query: 68 YDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGED-----CTARIWDLRSRNLQCQ 122 +D+++ + ++ + V F G + ++ + I+++ + + Sbjct: 79 WDVSNGQC--VATWKS-PVPVKRVEFSPCGNYFLAILDNVMKNPGSINIYEIERDSATHE 135 Query: 123 RIFQVNAPI------------NCVCLHPNQAELIVGDQSGAIHIWDLKTDHNE-QLIPEP 169 PI +I G + G I +D+ ++ I Sbjct: 136 LTKVSEEPIHKIITHEGLDAATVAGWSTKGKYIIAGHKDGKISKYDVSNNYEYVDSIDLH 195 Query: 170 EVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFS 229 E SI+ PD +Y + N ++ +++ + + + Sbjct: 196 EKSISDMQFSPDLTYFITSSRDTNSFLVDVSTLQVLKKYE---------TDCPLNTAVIT 246 Query: 230 PDSTLLATCSA----DQTCKIWRTSNFSLM--TELSIKSGNPGESSRGWMWGCAFSGDSQ 283 P + D T F ++ + + G + A S Sbjct: 247 PLKEFIILGGGQEAKDVTTTSANEGKFEARFYHKIFEEEIGRVQGHFGPLNTVAISPQGT 306 Query: 284 YIVTASSDNLARL 296 + D RL Sbjct: 307 SYASGGEDGFIRL 319 Score = 93.7 bits (231), Expect = 1e-19, Method: Composition-based stats. Identities = 36/241 (14%), Positives = 80/241 (33%), Gaps = 19/241 (7%) Query: 79 ISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHP 138 I G + + V ++++G +++ +D +A +W + + I + + Sbjct: 4 IKLTGHERPLTQVKYNKEGDLLFSCSKDSSASVW-YSLNGERLGTLDGHTGTIWSIDVDC 62 Query: 139 NQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAV-----NSTGN 193 + G +I +WD+ P V + P +Y A+ + G+ Sbjct: 63 FTKYCVTGSADYSIKLWDVSNGQCVATWKSP-VPVKRVEFSPCGNYFLAILDNVMKNPGS 121 Query: 194 CYVWNLTGGIGDEVTQLIPKTKIP---AHT--RYALQCRFSPDSTLLATCSADQTCKIWR 248 ++ + + + I H A +S + D + Sbjct: 122 INIYEIERDSATHELTKVSEEPIHKIITHEGLDAATVAGWSTKGKYIIAGHKDGKISKYD 181 Query: 249 TSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREY 308 SN + + + + FS D Y +T+S D + L V T ++ ++Y Sbjct: 182 VSNNY-------EYVDSIDLHEKSISDMQFSPDLTYFITSSRDTNSFLVDVSTLQVLKKY 234 Query: 309 G 309 Sbjct: 235 E 235 Score = 89.1 bits (219), Expect = 2e-18, Method: Composition-based stats. Identities = 27/218 (12%), Positives = 65/218 (29%), Gaps = 20/218 (9%) Query: 119 LQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHI 178 ++ ++ P+ V + L + + +W + +I S + Sbjct: 1 MKAIKLTGHERPLTQVKYNKEGDLLFSCSKDSSASVWYSLNGERLGTLDGHTGTIWSIDV 60 Query: 179 DPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATC 238 D Y ++ + +W+++ G + + FSP Sbjct: 61 DCFTKYCVTGSADYSIKLWDVSNGQCVATWKSPV---------PVKRVEFSPCGNYFLAI 111 Query: 239 SAD-----QTCKIWRTSNFSLMTELSI---KSGNPGESSRGWMWGC--AFSGDSQYIVTA 288 + + I+ S EL+ + + + G +S +YI+ Sbjct: 112 LDNVMKNPGSINIYEIERDSATHELTKVSEEPIHKIITHEGLDAATVAGWSTKGKYIIAG 171 Query: 289 SSDNLARLWCVETG-EIKREYGGHQKAVVCLAFNDSVL 325 D + V E H+K++ + F+ + Sbjct: 172 HKDGKISKYDVSNNYEYVDSIDLHEKSISDMQFSPDLT 209 Score = 63.2 bits (152), Expect = 1e-10, Method: Composition-based stats. Identities = 31/209 (14%), Positives = 64/209 (30%), Gaps = 20/209 (9%) Query: 33 ICTRTVQHQDS--QVNALEVTPDRSMIAAAGYQ-HIRMYDLNSNNPNPIISYDGVNKNIA 89 + + + I A I YD+ SNN + S D K+I+ Sbjct: 142 EPIHKIITHEGLDAATVAGWSTKGKYIIAGHKDGKISKYDV-SNNYEYVDSIDLHEKSIS 200 Query: 90 SVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGD-- 147 + F D + T D + + + LQ + ++ + P+N + P + +I+G Sbjct: 201 DMQFSPDLTYFITSSRDTNS--FLVDVSTLQVLKKYETDCPLNTAVITPLKEFIILGGGQ 258 Query: 148 QSGAIHIWDLKTDHNEQLI------------PEPEVSITSAHIDPDASYMAAVNSTGNCY 195 ++ + E + + I P + A+ G Sbjct: 259 EAKDVTTTSANEGKFEARFYHKIFEEEIGRVQGHFGPLNTVAISPQGTSYASGGEDGFIR 318 Query: 196 VWNLTGGIGDEVTQLIPKTKIPAHTRYAL 224 + + D + + H + A Sbjct: 319 LHHFEKSYFDFKYDVEKAAEAKEHMQEAN 347 >5A9Q-0 nrPDB Length = 380 Score = 106 bits (263), Expect = 2e-23, Method: Composition-based stats. Identities = 45/181 (24%), Positives = 79/181 (43%), Gaps = 6/181 (3%) Query: 6 GTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQ-VNALEV--TPDRSMIAAAGY 62 G V ++P I+ T G D + ++A RT+ + DS ++A+ TP+ + + G Sbjct: 136 GVVCNNPEIV-TVGEDGRINLFRADHKEAVRTIDNADSSTLHAVTFLRTPEILTVNSIGQ 194 Query: 63 QHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMY-TGGEDCTARIWDLRSRNLQC 121 I + N P+ I+S G + V H + + + TGG+D IWD+R + Sbjct: 195 LKIWDFRQQGNEPSQILSLTGDRVPLHCVDRHPNQQHVVATGGQDGMLSIWDVRQGTMPV 254 Query: 122 QRIFQVNAPINCVCLHPNQAE-LIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDP 180 + A + V HP+ E L + G++ WD TD E+ + +S + Sbjct: 255 SLLKAHEAEMWEVHFHPSNPEHLFTCSEDGSLWHWDASTDVPEKSSLFHQGGRSSTFLSH 314 Query: 181 D 181 Sbjct: 315 S 315 Score = 71.7 bits (174), Expect = 4e-13, Method: Composition-based stats. Identities = 44/305 (14%), Positives = 89/305 (29%), Gaps = 44/305 (14%) Query: 5 PGTVGSDPVILATAGYDHT---VRFWQAHS-------------GICTRTVQHQDSQVNAL 48 PG++ + AT +D+ + W ++H V L Sbjct: 23 PGSLQT-AETFATGSWDNEENYISLWSIGDFGNLDSDGGFEGDHQLLCDIRHH-GDVMDL 80 Query: 49 EVTPDRSMIAAAGYQHIRMY-----DLNSNNPNPIISYDGVN-------KNIASVGFHED 96 + ++AA+ + ++ + + + + G + Sbjct: 81 QFFDQERIVAASSTGCVTVFLHHPNNQTLSVNQQWTTAHYHTGPGSPSYSSAPCTGVVCN 140 Query: 97 GRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWD 156 + T GED ++ + ++ ++ V L V G + IWD Sbjct: 141 NPEIVTVGEDGRINLFRADHKEAVRTIDNADSSTLHAVTFLRTPEILTVNSI-GQLKIWD 199 Query: 157 LKTDHNE----QLIPEPEVSITSAHIDPDASYM-AAVNSTGNCYVWNLTGGIGDEVTQLI 211 + NE + V + P+ ++ A G +W++ G + Sbjct: 200 FRQQGNEPSQILSLTGDRVPLHCVDRHPNQQHVVATGGQDGMLSIWDVRQGT-------M 252 Query: 212 PKTKIPAHTRYALQCRFSPDS-TLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSR 270 P + + AH + F P + L TCS D + W S G + Sbjct: 253 PVSLLKAHEAEMWEVHFHPSNPEHLFTCSEDGSLWHWDASTDVPEKSSLFHQGGRSSTFL 312 Query: 271 GWMWG 275 Sbjct: 313 SHSIS 317 Score = 64.8 bits (156), Expect = 5e-11, Method: Composition-based stats. Identities = 42/299 (14%), Positives = 90/299 (30%), Gaps = 39/299 (13%) Query: 55 SMIAAAGYQH----IRMYDL-NSNNPNPIISYDG---------VNKNIASVGFHEDGRWM 100 A + + I ++ + + N + ++G + ++ + F + R + Sbjct: 30 ETFATGSWDNEENYISLWSIGDFGNLDSDGGFEGDHQLLCDIRHHGDVMDLQFFDQERIV 89 Query: 101 YTGGEDC-TARIWDLRSRNLQCQRI----FQVNAPIN-------CVCLHPNQAELIVGDQ 148 C T + ++ L + P + C + N E++ + Sbjct: 90 AASSTGCVTVFLHHPNNQTLSVNQQWTTAHYHTGPGSPSYSSAPCTGVVCNNPEIVTVGE 149 Query: 149 SGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVT 208 G I+++ + I + S A + VNS G +W+ + Sbjct: 150 DGRINLFRADHKEAVRTIDNADSSTLHAVTFLRTPEILTVNSIGQLKIWDFRQQGNEPSQ 209 Query: 209 QLIPKTKIPAHTRYALQCRFSPDST-LLATCSADQTCKIWRTSNFSLMTELSIKSGNPGE 267 L + P+ ++AT D IW ++ L + Sbjct: 210 IL----SLTGDRVPLHCVDRHPNQQHVVATGGQDGMLSIWDVRQGTMPVSL-------LK 258 Query: 268 SSRGWMWGCAFSGDSQ-YIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDSVL 325 + MW F + ++ T S D W T ++ HQ + S+ Sbjct: 259 AHEAEMWEVHFHPSNPEHLFTCSEDGSLWHWDASTDVPEKSSLFHQGGRSSTFLSHSIS 317 >5BJS-A nrPDB Length = 605 Score = 104 bits (259), Expect = 5e-23, Method: Composition-based stats. Identities = 37/179 (20%), Positives = 71/179 (39%), Gaps = 21/179 (11%) Query: 10 SDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQ--HIRM 67 +D +L AG + V+ + G RT+ +N L +P I A+ IR+ Sbjct: 146 TDQPLLCIAGNEGNVKVYNVTEGKLYRTLVGHGGGINDLATSPANPYIIASASDDTTIRI 205 Query: 68 YDLNSNN----PNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQR 123 + L + I+ +G + ++ SV FH++GR++ + G D +W L + Sbjct: 206 WSLAPEHEKQPCVCILGGEGHSYDLLSVAFHDNGRYVLSAGHDQVINLWALPEFPNEHME 265 Query: 124 IF------------QVNAPINCVCLHPNQAELIV-GDQSGAIHIWDLKTDHNEQLIPEP 169 I N ++CV + ++ I +W ++ ++ IP P Sbjct: 266 IPIVIYYPHFSSSEIHNNLVDCVAFY--GDLILSRACHEDTIVLWRIEGFSSDDPIPGP 322 Score = 78.3 bits (191), Expect = 4e-15, Method: Composition-based stats. Identities = 27/170 (15%), Positives = 56/170 (32%), Gaps = 11/170 (6%) Query: 138 PNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYM-AAVNSTGNCYV 196 +Q L + G + ++++ + + I P Y+ A+ + + Sbjct: 146 TDQPLLCIAGNEGNVKVYNVTEGKLYRTLVGHGGGINDLATSPANPYIIASASDDTTIRI 205 Query: 197 WNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNF---- 252 W+L + I H+ L F + + + DQ +W F Sbjct: 206 WSLAPEHEKQPCVCILGG--EGHSYDLLSVAFHDNGRYVLSAGHDQVINLWALPEFPNEH 263 Query: 253 -SLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVT-ASSDNLARLWCVE 300 + + + E + AF GD I++ A ++ LW +E Sbjct: 264 MEIPIVIYYPHFSSSEIHNNLVDCVAFYGD--LILSRACHEDTIVLWRIE 311 Score = 60.9 bits (146), Expect = 7e-10, Method: Composition-based stats. Identities = 26/145 (17%), Positives = 55/145 (37%), Gaps = 21/145 (14%) Query: 5 PGTVGSDPVILATAGYDHTVRFWQA------HSGICTRTVQHQDSQVNALEVTPDRSMIA 58 T ++P I+A+A D T+R W +C + + ++ + + Sbjct: 184 LATSPANPYIIASASDDTTIRIWSLAPEHEKQPCVCILGGEGHSYDLLSVAFHDNGRYVL 243 Query: 59 AAGYQH-IRMYDL----NSNNPNPIISY-------DGVNKNIASVGFHEDGRWMYT-GGE 105 +AG+ I ++ L N + PI+ Y + N + V F+ G + + Sbjct: 244 SAGHDQVINLWALPEFPNEHMEIPIVIYYPHFSSSEIHNNLVDCVAFY--GDLILSRACH 301 Query: 106 DCTARIWDLRSRNLQCQRIFQVNAP 130 + T +W + + ++AP Sbjct: 302 EDTIVLWRIEGFSSDDPIPGPLDAP 326 Score = 60.5 bits (145), Expect = 8e-10, Method: Composition-based stats. Identities = 30/156 (19%), Positives = 51/156 (32%), Gaps = 20/156 (12%) Query: 180 PDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQC-RFSPD----STL 234 P A + A S + + LT + I A +S D L Sbjct: 91 PGAPPVFAATSKKHAVICRLTQTTDKDANPCEIIQLIRDDGNEANCASCWSKDPITDQPL 150 Query: 235 LATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIV-TASSDNL 293 L + K++ + L L G + A S + YI+ +AS D Sbjct: 151 LCIAGNEGNVKVYNVTEGKLYRTLVGHGG--------GINDLATSPANPYIIASASDDTT 202 Query: 294 ARLWCV------ETGEIKREYGGHQKAVVCLAFNDS 323 R+W + + GH ++ +AF+D+ Sbjct: 203 IRIWSLAPEHEKQPCVCILGGEGHSYDLLSVAFHDN 238 >4OWR-A nrPDB Length = 339 Score = 103 bits (256), Expect = 1e-22, Method: Composition-based stats. Identities = 54/293 (18%), Positives = 99/293 (33%), Gaps = 20/293 (6%) Query: 42 DSQVNALEVTPD---RSMIAAAGY-QHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDG 97 D + L +P + + A + +R +++ + + + V + +DG Sbjct: 10 DDSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDG 69 Query: 98 RWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCL--HPNQAELIVGDQSGAIHIW 155 ++T D TA++WDL S Q +I Q +AP+ + PN + ++ G + W Sbjct: 70 SKVFTASCDKTAKMWDLSSN--QAIQIAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFW 127 Query: 156 DLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTK 215 D ++ + ++ PE + I P A + A G V+ L + P Sbjct: 128 DTRSSNPMMVLQLPERCYCADVIYPMA--VVATAERGLI-VYQLENQPSEFRRIESPLK- 183 Query: 216 IPAHTRYALQCRFSPDSTLLATCSADQTCKIWRT-------SNFSLMTELSIKSGNPGES 268 H A+ T A S + I NF+ S + Sbjct: 184 -HQHRCVAIFKDKQNKPTGFALGSIEGRVAIHYINPPNPAKDNFTFKCHRSNGTNTSAPQ 242 Query: 269 SRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFN 321 + G AF + T SD W + + + + FN Sbjct: 243 DIYAVNGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQPISACCFN 295 Score = 72.5 bits (176), Expect = 2e-13, Method: Composition-based stats. Identities = 35/257 (13%), Positives = 79/257 (30%), Gaps = 41/257 (15%) Query: 9 GSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEV--TPDRSMIAAAGYQ-HI 65 D + TA D T + W S + + D+ V + P+ S + + + Sbjct: 66 SDDGSKVFTASCDKTAKMWDLSSNQAIQ-IAQHDAPVKTIHWIKAPNYSCVMTGSWDKTL 124 Query: 66 RMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRI- 124 + +D S+NP ++ A V + + ++ L ++ + +RI Sbjct: 125 KFWDTRSSNPMMVLQLP-ERCYCADVIY----PMAVVATAERGLIVYQLENQPSEFRRIE 179 Query: 125 --FQVNAPINCVCLHPN----QAELIVGDQSGAIHIWDLKTDHNEQ---LIPEPEVS--- 172 + CV + + +G G + I + + + + Sbjct: 180 SPLKHQHR--CVAIFKDKQNKPTGFALGSIEGRVAIHYINPPNPAKDNFTFKCHRSNGTN 237 Query: 173 ---------ITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYA 223 + P +A V S G W+ + ++ + + Sbjct: 238 TSAPQDIYAVNGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQ--------PI 289 Query: 224 LQCRFSPDSTLLATCSA 240 C F+ + + A S+ Sbjct: 290 SACCFNHNGNIFAYASS 306 Score = 32.8 bits (73), Expect = 0.19, Method: Composition-based stats. Identities = 11/55 (20%), Positives = 24/55 (43%), Gaps = 5/55 (9%) Query: 273 MWGCAFSGD---SQYIVTASSDNLARLWCVE-TGEIK-REYGGHQKAVVCLAFND 322 + +FS +++ S N R W V+ +G+ + H V+ + ++D Sbjct: 13 IGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSD 67 >6BX3-B nrPDB Length = 412 Score = 102 bits (254), Expect = 2e-22, Method: Composition-based stats. Identities = 50/308 (16%), Positives = 116/308 (37%), Gaps = 21/308 (6%) Query: 33 ICTRTVQHQDSQVNALEVTPDRSMIAAA-GYQHIRMYDLNSNNPNPIIS--YDGVNKNIA 89 T T+++ L+ +P +A + +YD+++ P + + I Sbjct: 17 KLTHTIENPLR-TECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPIT 75 Query: 90 SVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGD-- 147 S+ + DGR + T D + ++WDL S+ + + + ++PI + L V Sbjct: 76 SIAWSPDGRLLLTSSRDWSIKLWDL-SKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIF 134 Query: 148 QSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNST-------GNCYVWNLT 200 + ++ D D L+ + + S+ D + V++ G W L Sbjct: 135 EESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGW-LD 193 Query: 201 GGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIW--RTSNFSLMTEL 258 + Q + + S + LA +D+T + + + + EL Sbjct: 194 FYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVEL 253 Query: 259 SIKSGNPGESSRGWMWGCAFSGDS-QYIVT---ASSDNLARLWCVETGEIKREYGGHQKA 314 +++ ++ FS ++ +Y+V SS + +W +G + R G ++ Sbjct: 254 TLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEE 313 Query: 315 VVCLAFND 322 ++ + ++ Sbjct: 314 LIDINWDF 321 Score = 59.4 bits (142), Expect = 2e-09, Method: Composition-based stats. Identities = 40/301 (13%), Positives = 83/301 (27%), Gaps = 49/301 (16%) Query: 9 GSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMY 68 D +L T+ D +++ W DS + + R+ Sbjct: 80 SPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWL----------DAKRRLC 129 Query: 69 DLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVN 128 + D N +AS+ D + + + + + Sbjct: 130 VATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLV-----------CTVHTK 178 Query: 129 APINCVCLHPNQAELIVGDQSGAIHIW---DLKTDHNEQLIPEPEVSITSAHIDPDASYM 185 P +IVG G + + L + +I + + + Sbjct: 179 HP----------NIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERL 228 Query: 186 AAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYA--LQCRFSPD--STLLAT--CS 239 A S + ++ + +L + K FS + L+A+ S Sbjct: 229 AINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGS 288 Query: 240 ADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVT-ASSDNLARLWC 298 + IW T++ +L+ L E + + + S IV+ +W Sbjct: 289 SAHELYIWETTSGTLVRVL--------EGAEEELIDINWDFYSMSIVSNGFESGNVYVWS 340 Query: 299 V 299 V Sbjct: 341 V 341 Score = 57.1 bits (136), Expect = 9e-09, Method: Composition-based stats. Identities = 30/234 (12%), Positives = 63/234 (26%), Gaps = 48/234 (20%) Query: 114 LRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNE----QLIPEP 169 L+ + + C+ P L +G +GA+ I+D+ T ++ Sbjct: 11 LKEHPEKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAH 70 Query: 170 EVSITSAHIDPDASYMAAVNSTGNCYVWNLT-----------------GGIGDEVTQLIP 212 ITS PD + + + +W+L+ D +L Sbjct: 71 VRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCV 130 Query: 213 KTKIPAHTRYALQCR-------FSPDSTLLATCSAD-------------------QTCKI 246 T Y + S + + D T K Sbjct: 131 ATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKG 190 Query: 247 WRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVE 300 W + + + + + + + S + + + SD R + + Sbjct: 191 W-LDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEIS 243 >5WYJ-BE nrPDB Length = 939 Score = 100 bits (250), Expect = 6e-22, Method: Composition-based stats. Identities = 46/276 (16%), Positives = 94/276 (34%), Gaps = 20/276 (7%) Query: 15 LATAGYDHT-VRFWQAHSGICTR-TVQHQD-SQVNALEVTPDRSM-IAAAGYQHIRMYDL 70 + TA D R W + R T D V ++ ++ + + I +Y++ Sbjct: 430 IITAHKDEKFARTWDMRNKRVGRWTFDTTDDGFVKSVAMSQCGNFGFIGSSNGSITIYNM 489 Query: 71 NSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAP 130 S + + + R M + G D +D L +++AP Sbjct: 490 QSGILRKKYKL--HKRAVTGISLDGMNRKMVSCGLDGIVGFYDFNKSTL--LGKLKLDAP 545 Query: 131 INCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNS 190 I + H + + +I + D T + + IT+ P+ ++ + + Sbjct: 546 ITAMVYHRSSDLFALALDDLSIVVIDAVTQRVVRQLWGHSNRITAFDFSPEGRWIVSASL 605 Query: 191 TGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQT-CKIWRT 249 W+L G + + A +FSP+ LLAT IW Sbjct: 606 DSTIRTWDLPTGGCIDGIIV---------DNVATNVKFSPNGDLLATTHVTGNGICIW-- 654 Query: 250 SNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYI 285 +N + +S ++ + E +R + + G+ + Sbjct: 655 TNRAQFKTVSTRTIDESEFARMALPSTSVRGNDSML 690 Score = 91.4 bits (225), Expect = 5e-19, Method: Composition-based stats. Identities = 45/296 (15%), Positives = 100/296 (33%), Gaps = 43/296 (14%) Query: 35 TRTVQHQDSQVNALEVTPDRS--MIAAAGYQHIRMYDLNSNNPNPIISYDGVNK------ 86 R+ + + +S M++A+ + + + L + + +S K Sbjct: 343 LRSRGGHSQPPSYIAFADSQSHFMLSASKDRSLWSFSLRKDAQSQEMSQRLHKKQDGGRV 402 Query: 87 ----------NIASVGFHED--GRW--MYTGGED-CTARIWDLRSRNLQCQRIF--QVNA 129 I ++ G W + T +D AR WD+R++ + + F + Sbjct: 403 GGSTIKSKFPEIVALAIENARIGEWENIITAHKDEKFARTWDMRNKRV-GRWTFDTTDDG 461 Query: 130 PINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVN 189 + V + +G +G+I I+++++ + + ++T +D M + Sbjct: 462 FVKSVAMSQCGNFGFIGSSNGSITIYNMQSGILRKKYKLHKRAVTGISLDGMNRKMVSCG 521 Query: 190 STGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRT 249 G ++ +L + S L A D + + Sbjct: 522 LDGIVGFYDFNKSTLLGKLKL---------DAPITAMVYHRSSDLFALALDDLSIVVIDA 572 Query: 250 SNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIK 305 ++ +L S + FS + ++IV+AS D+ R W + TG Sbjct: 573 VTQRVVRQLWGHSNR--------ITAFDFSPEGRWIVSASLDSTIRTWDLPTGGCI 620 Score = 70.9 bits (172), Expect = 6e-13, Method: Composition-based stats. Identities = 47/361 (13%), Positives = 101/361 (27%), Gaps = 68/361 (18%) Query: 2 NTSPGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIA-AA 60 + S GT D L D R + + V + +I + Sbjct: 263 HLSVGTSSGD---LIFYDLDRRSRI-----HVLKNIHRESYGGVTQATFLNGQPIIVTSG 314 Query: 61 GYQHIRMY-----------DLNSNNPNPIISYDGVNKNIASVGF-HEDGRWMYTGGEDCT 108 G ++ Y D+ P + S G ++ + + F +M + +D + Sbjct: 315 GDNSLKEYVFDPSLSQGSGDVVVQPPRYLRSRGGHSQPPSYIAFADSQSHFMLSASKDRS 374 Query: 109 ARIWDL------------------RSRNLQCQRIFQVNAPINCVCLHPNQAEL------I 144 +W + + P V L A + I Sbjct: 375 --LWSFSLRKDAQSQEMSQRLHKKQDGGRVGGSTIKSKFP-EIVALAIENARIGEWENII 431 Query: 145 VGDQSGAI-HIWDLKTDHNEQLI--PEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTG 201 + WD++ + + + S + ++ +S G+ ++N+ Sbjct: 432 TAHKDEKFARTWDMRNKRVGRWTFDTTDDGFVKSVAMSQCGNFGFIGSSNGSITIYNMQS 491 Query: 202 GIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIK 261 GI + +L H R + + +C D + + +L+ +L + Sbjct: 492 GILRKKYKL--------HKRAVTGISLDGMNRKMVSCGLDGIVGFYDFNKSTLLGKLKL- 542 Query: 262 SGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFN 321 + + S A D + T + R+ GH + F+ Sbjct: 543 --------DAPITAMVYHRSSDLFALALDDLSIVVIDAVTQRVVRQLWGHSNRITAFDFS 594 Query: 322 D 322 Sbjct: 595 P 595 Score = 64.8 bits (156), Expect = 6e-11, Method: Composition-based stats. Identities = 42/326 (12%), Positives = 105/326 (32%), Gaps = 50/326 (15%) Query: 13 VILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRS--MIAAAGYQHIRMYDL 70 I+A V + G RT++ S++++L D S + + YDL Sbjct: 219 DIIALGTVTGEVIMFNMRKGKRIRTIKIPQSRISSLSFRTDGSSHLSVGTSSGDLIFYDL 278 Query: 71 NSNNPNPIIS--YDGVNKNIASVGFHEDGRWMYTGGEDCTAR--IWD----------LRS 116 + + ++ + + F + T G D + + ++D + Sbjct: 279 DRRSRIHVLKNIHRESYGGVTQATFLNGQPIIVTSGGDNSLKEYVFDPSLSQGSGDVVVQ 338 Query: 117 RNLQCQRIFQVNAPINCVCLHPNQAEL-IVGDQSGAIHIWDLKTDHNEQLIPEPEVSITS 175 + + P + + +Q+ + + ++ + L+ D Q + + Sbjct: 339 PPRYLRSRGGHSQPPSYIAFADSQSHFMLSASKDRSLWSFSLRKDAQSQEMSQR------ 392 Query: 176 AHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLL 235 H D + ST + + + I AH Sbjct: 393 LHKKQDGGRV--GGSTIKSKFPEIVALAIENARIGEWENIITAHKD-------------- 436 Query: 236 ATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLAR 295 ++ + W N + + G++ A S + SS+ Sbjct: 437 -----EKFARTWDMRNK------RVGRWTFDTTDDGFVKSVAMSQCGNFGFIGSSNGSIT 485 Query: 296 LWCVETGEIKREYGGHQKAVVCLAFN 321 ++ +++G ++++Y H++AV ++ + Sbjct: 486 IYNMQSGILRKKYKLHKRAVTGISLD 511 Score = 52.5 bits (124), Expect = 2e-07, Method: Composition-based stats. Identities = 20/93 (21%), Positives = 37/93 (39%), Gaps = 4/93 (4%) Query: 12 PVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQ-HIRMYDL 70 + A A D ++ A + R + +++ A + +P+ I +A IR +DL Sbjct: 555 SDLFALALDDLSIVVIDAVTQRVVRQLWGHSNRITAFDFSPEGRWIVSASLDSTIRTWDL 614 Query: 71 NSNNPNPIISYDGVNKNIASVGFHEDGRWMYTG 103 + I D V N+ F +G + T Sbjct: 615 PTGGCIDGIIVDNVATNVK---FSPNGDLLATT 644 Score = 42.4 bits (98), Expect = 2e-04, Method: Composition-based stats. Identities = 10/51 (19%), Positives = 23/51 (45%), Gaps = 1/51 (1%) Query: 9 GSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAA 59 + + +A D T+R W +G C + D+ ++ +P+ ++A Sbjct: 594 SPEGRWIVSASLDSTIRTWDLPTGGCIDGIIV-DNVATNVKFSPNGDLLAT 643 >3BG0-A nrPDB Length = 316 Score = 99.1 bits (245), Expect = 2e-21, Method: Composition-based stats. Identities = 49/287 (17%), Positives = 99/287 (34%), Gaps = 39/287 (13%) Query: 41 QDSQVNALEVTPDRSMIAA-AGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHED--G 97 + ++ ++ + +A + + ++++D+ + I G + V + G Sbjct: 12 HEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYG 71 Query: 98 RWMYTGGEDCTARIWDLRSRNLQCQRIF-QVNAPINCVCLHPNQAELI--VGDQSGAIHI 154 + + D IW + + ++ +N VC P+ LI G GAI + Sbjct: 72 NILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISL 131 Query: 155 --------WDLKTDHNEQLI------PEPEVSITSAHIDPDA------SYMAAVNSTGNC 194 W++K +N I P V S P A+ Sbjct: 132 LTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLI 191 Query: 195 YVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPD----STLLATCSADQTCKIWRTS 250 +W +E Q + K+ AH+ + ++P ++ +A+CS D IW Sbjct: 192 KLW-----KEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCD 246 Query: 251 NFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLW 297 + S + S +W ++S + + + DN LW Sbjct: 247 DASS----NTWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLW 289 Score = 94.1 bits (232), Expect = 8e-20, Method: Composition-based stats. Identities = 37/267 (13%), Positives = 82/267 (30%), Gaps = 37/267 (13%) Query: 15 LATAGYDHTVRFWQAHSG--ICTRTVQHQDSQVNALEV--TPDRSMIAAAG-YQHIRMYD 69 LAT D +V+ + +G I ++ + V + +++A+ + + ++ Sbjct: 28 LATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWR 87 Query: 70 LNSNNPNPIISYDGVNKNIASVGF--HEDGRWMYTGGEDCTARI--WDLRSRNLQCQRIF 125 + + G + ++ SV + H+ G + G D + + + + Sbjct: 88 EENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINN 147 Query: 126 QVNAPINCVCL-----------HPNQ------AELIVGDQSGAIHIWDLKTD---HNEQL 165 N V HP+ G I +W + D EQ Sbjct: 148 AHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQK 207 Query: 166 IPEPEVSITSAHIDPD----ASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTR 221 + + P S +A+ + G ++W D + + Sbjct: 208 LEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIW----TCDDASSNTWSPKLLHKFND 263 Query: 222 YALQCRFSPDSTLLATCSADQTCKIWR 248 +S + +LA D +W+ Sbjct: 264 VVWHVSWSITANILAVSGGDNKVTLWK 290 Score = 82.1 bits (201), Expect = 3e-16, Method: Composition-based stats. Identities = 39/270 (14%), Positives = 75/270 (27%), Gaps = 36/270 (13%) Query: 83 GVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQR-IFQVNAPINCVCL-HP-N 139 I G + T D + +I+D+R+ + P+ V HP Sbjct: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMY 70 Query: 140 QAELIVGDQSGAIHIWDLKTDHNEQLIP--EPEVSITSAHIDPD--ASYMAAVNSTGNCY 195 L + IW + E+ + S+ S P +A +S G Sbjct: 71 GNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAIS 130 Query: 196 V--------WNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDS------TLLATCSAD 241 + W + + PA +L P A+ D Sbjct: 131 LLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLID--HPSGQKPNYIKRFASGGCD 188 Query: 242 QTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGD----SQYIVTASSDNLARLW 297 K+W+ E E+ W+ A++ + I + S D +W Sbjct: 189 NLIKLWKEEEDGQWKE-----EQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIW 243 Query: 298 CVETGEIK----REYGGHQKAVVCLAFNDS 323 + + V ++++ + Sbjct: 244 TCDDASSNTWSPKLLHKFNDVVWHVSWSIT 273 Score = 74.8 bits (182), Expect = 4e-14, Method: Composition-based stats. Identities = 27/206 (13%), Positives = 61/206 (29%), Gaps = 27/206 (13%) Query: 140 QAELIVGDQSGAIHIWDLKTDHNEQL--IPEPEVSITSAHIDPD--ASYMAAVNSTGNCY 195 L ++ I+D++ + + E + + +A+ + Sbjct: 25 GTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVI 84 Query: 196 VWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPD--STLLATCSADQTCKIWR-TSNF 252 +W G ++ + H ++P +LA S+D + T Sbjct: 85 IWREENGTWEKSHEH------AGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEG 138 Query: 253 SLMTELSIKSGNPGESSRGWMWGCAF-----SGDSQ------YIVTASSDNLARLWCVET 301 + + G ++ W Q + DNL +LW E Sbjct: 139 QWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEE 198 Query: 302 G---EIKREYGGHQKAVVCLAFNDSV 324 + +++ H V +A+ S+ Sbjct: 199 DGQWKEEQKLEAHSDWVRDVAWAPSI 224 Score = 70.6 bits (171), Expect = 8e-13, Method: Composition-based stats. Identities = 37/219 (16%), Positives = 73/219 (33%), Gaps = 33/219 (15%) Query: 12 PVILATAGYDHTVRFWQAHSG--ICTRTVQHQDSQVNALEVTP-DRSMIAAAGYQHIRMY 68 ILA+ YD V W+ +G + DS VN++ P D +I A G + Sbjct: 71 GNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAIS 130 Query: 69 DLNSNNPNPI---ISYDGVNKNIASVGF-----------HEDGR------WMYTGGEDCT 108 L + +V + H G+ +GG D Sbjct: 131 LLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNL 190 Query: 109 ARIW--DLRSRNLQCQRIFQVNAPINCVCLHPN----QAELIVGDQSGAIHIW---DLKT 159 ++W + + + Q++ + + V P+ + + Q G + IW D + Sbjct: 191 IKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASS 250 Query: 160 DH-NEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVW 197 + + +L+ + + A+ +A +W Sbjct: 251 NTWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLW 289 Score = 60.9 bits (146), Expect = 6e-10, Method: Composition-based stats. Identities = 33/165 (20%), Positives = 57/165 (34%), Gaps = 17/165 (10%) Query: 167 PEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQC 226 E I A +D + +A +S + ++++ G I + H Q Sbjct: 10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNG------GQILIADLRGHEGPVWQV 63 Query: 227 RF-SP-DSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQY 284 + P +LA+CS D+ IWR N + + G S A Sbjct: 64 AWAHPMYGNILASCSYDRKVIIWREENGTWEKS----HEHAGHDSSVNSVCWAPHDYGLI 119 Query: 285 IVTASSDNLARLWCVETG----EIKREYGGHQKAVVCLAFNDSVL 325 + SSD L TG E+K+ H +++ +V+ Sbjct: 120 LACGSSDGAISL-LTYTGEGQWEVKKINNAHTIGCNAVSWAPAVV 163 Score = 57.1 bits (136), Expect = 9e-09, Method: Composition-based stats. Identities = 25/114 (21%), Positives = 42/114 (36%), Gaps = 10/114 (8%) Query: 217 PAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGC 276 +H + T LATCS+D++ KI+ N + G +W Sbjct: 10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQI------LIADLRGHEGPVWQV 63 Query: 277 AFSGD--SQYIVTASSDNLARLWCVETG--EIKREYGGHQKAVVCLAFNDSVLG 326 A++ + + S D +W E G E E+ GH +V + + G Sbjct: 64 AWAHPMYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYG 117 >5A31-R nrPDB Length = 386 Score = 98.7 bits (244), Expect = 3e-21, Method: Composition-based stats. Identities = 35/251 (13%), Positives = 87/251 (34%), Gaps = 19/251 (7%) Query: 15 LATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLNSNN 74 LA + V + C RT+ +V L + + +G + R+ + Sbjct: 146 LAVGQANGLVEIYDVMKRKCIRTLSGHIDRVACLSWN---NHVLTSGSRDHRILHRDVRM 202 Query: 75 PNPII-SYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINC 133 P+P + + + + + ++ + +GG D +++ + + A + Sbjct: 203 PDPFFETIESHTQEVCGLKWNVADNKLASGGNDNVVHVYE-GTSKSPILTFDEHKAAVKA 261 Query: 134 VCLHPNQAELIV---GDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAA--V 188 + P++ ++ G + IW++ T I + + + Sbjct: 262 MAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDIDSGSQICN-MVWSKNTNELVTSHG 320 Query: 189 NSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWR 248 S N +W+ + P + H+ L S D T + + + D+T + W+ Sbjct: 321 YSKYNLTLWDCNS--------MDPIAILKGHSFRVLHLTLSNDGTTVVSGAGDETLRYWK 372 Query: 249 TSNFSLMTELS 259 + S++ + Sbjct: 373 LFDVSVLNLFT 383 Score = 86.7 bits (213), Expect = 1e-17, Method: Composition-based stats. Identities = 34/258 (13%), Positives = 78/258 (30%), Gaps = 27/258 (10%) Query: 46 NALEVTPDRSMIAAA-GYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGG 104 +L S +A + +YD+ I + G +A + + + + +G Sbjct: 135 TSLSWIGAGSHLAVGQANGLVEIYDVMKRKC--IRTLSGHIDRVACLSW--NNHVLTSGS 190 Query: 105 EDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQ 164 D D+R + + I + + + +L G +H+++ + Sbjct: 191 RDHRILHRDVRMPDPFFETIESHTQEVCGLKWNVADNKLASGGNDNVVHVYEGTSKSPIL 250 Query: 165 LIPEPEVSITSAHIDPDASYMAA---VNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTR 221 E + ++ + P + A + +WN+ I + Sbjct: 251 TFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDIDSGSQ-------- 302 Query: 222 YALQCRFSPDSTLLAT--CSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFS 279 +S ++ L T + +W ++ + L S S Sbjct: 303 -ICNMVWSKNTNELVTSHGYSKYNLTLWDCNSMDPIAILKGHSFRVLH--------LTLS 353 Query: 280 GDSQYIVTASSDNLARLW 297 D +V+ + D R W Sbjct: 354 NDGTTVVSGAGDETLRYW 371 Score = 84.4 bits (207), Expect = 6e-17, Method: Composition-based stats. Identities = 49/289 (16%), Positives = 98/289 (33%), Gaps = 31/289 (10%) Query: 41 QDSQVNALEVTPDRSMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWM 100 D +L ++A A + I + D N+ + + + S+ + G + Sbjct: 90 ADDFYYSLIDWSSTDVLAVALGKSIFLTDNNTGDVVHLCDTENEY---TSLSWIGAGSHL 146 Query: 101 YTGGEDCTARIWDLRSRNLQCQRIFQVNAP-INCVCLHPNQAELIVGDQSGAIHIWDLK- 158 G + I+D+ +C R + + C+ N L G + I D++ Sbjct: 147 AVGQANGLVEIYDV--MKRKCIRTLSGHIDRVACLSW--NNHVLTSGSRDHRILHRDVRM 202 Query: 159 TDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPA 218 D + I + + + +A+ + +V+ T P Sbjct: 203 PDPFFETIESHTQEVCGLKWNVADNKLASGGNDNVVHVYEGTSKS--------PILTFDE 254 Query: 219 HTRYALQCRFSPDST-LLATC--SADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWG 275 H +SP +LAT +AD+ KIW + M+++ S + Sbjct: 255 HKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDI---------DSGSQICN 305 Query: 276 CAFSGDSQYIVT--ASSDNLARLWCVETGEIKREYGGHQKAVVCLAFND 322 +S ++ +VT S LW + + GH V+ L ++ Sbjct: 306 MVWSKNTNELVTSHGYSKYNLTLWDCNSMDPIAILKGHSFRVLHLTLSN 354 Score = 53.2 bits (126), Expect = 1e-07, Method: Composition-based stats. Identities = 23/106 (21%), Positives = 46/106 (43%), Gaps = 8/106 (7%) Query: 14 ILATAG--YDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAA---GYQHIRMY 68 +LAT G D ++ W ++ I + SQ+ + + + + + + ++ ++ Sbjct: 271 VLATGGGTADRRLKIWNVNTSIKMSDID-SGSQICNMVWSKNTNELVTSHGYSKYNLTLW 329 Query: 69 DLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDL 114 D NS +P I G + + + DG + +G D T R W L Sbjct: 330 DCNSMDPIAI--LKGHSFRVLHLTLSNDGTTVVSGAGDETLRYWKL 373 Score = 47.5 bits (111), Expect = 9e-06, Method: Composition-based stats. Identities = 12/61 (19%), Positives = 25/61 (40%) Query: 265 PGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDSV 324 + ++ G ++ ++ L ++ V + R GH V CL++N+ V Sbjct: 126 HLCDTENEYTSLSWIGAGSHLAVGQANGLVEIYDVMKRKCIRTLSGHIDRVACLSWNNHV 185 Query: 325 L 325 L Sbjct: 186 L 186 >4BH6-A nrPDB Length = 308 Score = 96.0 bits (237), Expect = 2e-20, Method: Composition-based stats. Identities = 34/244 (13%), Positives = 83/244 (34%), Gaps = 19/244 (7%) Query: 15 LATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLNSNN 74 LA + V + C RT+ +V L + + +G + R+ + Sbjct: 77 LAVGQANGLVEIYDVMKRKCIRTLSGHIDRVACLSWN---NHVLTSGSRDHRILHRDVRM 133 Query: 75 PNPII-SYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINC 133 P+P + + + + + ++ + +GG D +++ + + A + Sbjct: 134 PDPFFETIESHTQEVCGLKWNVADNKLASGGNDNVVHVYE-GTSKSPILTFDEHKAAVKA 192 Query: 134 VCLHPNQAELIV---GDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAA--V 188 + P++ ++ G + IW++ T I + + + Sbjct: 193 MAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDIDSGSQICN-MVWSKNTNELVTSHG 251 Query: 189 NSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWR 248 S N +W+ + P + H+ L S D T + + + D+T + W+ Sbjct: 252 YSKYNLTLWDCNS--------MDPIAILKGHSFRVLHLTLSNDGTTVVSGAGDETLRYWK 303 Query: 249 TSNF 252 + Sbjct: 304 LFDK 307 Score = 84.8 bits (208), Expect = 4e-17, Method: Composition-based stats. Identities = 34/258 (13%), Positives = 78/258 (30%), Gaps = 27/258 (10%) Query: 46 NALEVTPDRSMIAAA-GYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGG 104 +L S +A + +YD+ I + G +A + + + + +G Sbjct: 66 TSLSWIGAGSHLAVGQANGLVEIYDVMKRKC--IRTLSGHIDRVACLSW--NNHVLTSGS 121 Query: 105 EDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQ 164 D D+R + + I + + + +L G +H+++ + Sbjct: 122 RDHRILHRDVRMPDPFFETIESHTQEVCGLKWNVADNKLASGGNDNVVHVYEGTSKSPIL 181 Query: 165 LIPEPEVSITSAHIDPDASYMAA---VNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTR 221 E + ++ + P + A + +WN+ I + Sbjct: 182 TFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDIDSGSQ-------- 233 Query: 222 YALQCRFSPDSTLLAT--CSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFS 279 +S ++ L T + +W ++ + L S S Sbjct: 234 -ICNMVWSKNTNELVTSHGYSKYNLTLWDCNSMDPIAILKGHSFRVLH--------LTLS 284 Query: 280 GDSQYIVTASSDNLARLW 297 D +V+ + D R W Sbjct: 285 NDGTTVVSGAGDETLRYW 302 Score = 82.5 bits (202), Expect = 2e-16, Method: Composition-based stats. Identities = 49/289 (16%), Positives = 98/289 (33%), Gaps = 31/289 (10%) Query: 41 QDSQVNALEVTPDRSMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWM 100 D +L ++A A + I + D N+ + + + S+ + G + Sbjct: 21 ADDFYYSLIDWSSTDVLAVALGKSIFLTDNNTGDVVHLCDTENEY---TSLSWIGAGSHL 77 Query: 101 YTGGEDCTARIWDLRSRNLQCQRIFQVNAP-INCVCLHPNQAELIVGDQSGAIHIWDLK- 158 G + I+D+ +C R + + C+ N L G + I D++ Sbjct: 78 AVGQANGLVEIYDV--MKRKCIRTLSGHIDRVACLSW--NNHVLTSGSRDHRILHRDVRM 133 Query: 159 TDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPA 218 D + I + + + +A+ + +V+ T P Sbjct: 134 PDPFFETIESHTQEVCGLKWNVADNKLASGGNDNVVHVYEGTSKS--------PILTFDE 185 Query: 219 HTRYALQCRFSPDST-LLATC--SADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWG 275 H +SP +LAT +AD+ KIW + M+++ S + Sbjct: 186 HKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDI---------DSGSQICN 236 Query: 276 CAFSGDSQYIVT--ASSDNLARLWCVETGEIKREYGGHQKAVVCLAFND 322 +S ++ +VT S LW + + GH V+ L ++ Sbjct: 237 MVWSKNTNELVTSHGYSKYNLTLWDCNSMDPIAILKGHSFRVLHLTLSN 285 Score = 52.5 bits (124), Expect = 3e-07, Method: Composition-based stats. Identities = 23/110 (20%), Positives = 47/110 (42%), Gaps = 8/110 (7%) Query: 14 ILATAG--YDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAA---GYQHIRMY 68 +LAT G D ++ W ++ I + SQ+ + + + + + + ++ ++ Sbjct: 202 VLATGGGTADRRLKIWNVNTSIKMSDID-SGSQICNMVWSKNTNELVTSHGYSKYNLTLW 260 Query: 69 DLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRN 118 D NS +P I G + + + DG + +G D T R W L + Sbjct: 261 DCNSMDPIAI--LKGHSFRVLHLTLSNDGTTVVSGAGDETLRYWKLFDKP 308 Score = 46.7 bits (109), Expect = 1e-05, Method: Composition-based stats. Identities = 12/61 (19%), Positives = 25/61 (40%) Query: 265 PGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDSV 324 + ++ G ++ ++ L ++ V + R GH V CL++N+ V Sbjct: 57 HLCDTENEYTSLSWIGAGSHLAVGQANGLVEIYDVMKRKCIRTLSGHIDRVACLSWNNHV 116 Query: 325 L 325 L Sbjct: 117 L 117 >5WLC-LJ nrPDB Length = 513 Score = 94.4 bits (233), Expect = 6e-20, Method: Composition-based stats. Identities = 41/304 (13%), Positives = 92/304 (30%), Gaps = 23/304 (7%) Query: 25 RFWQAHSGICTRTVQHQDSQVNALEVTPDRSM-IAAAGYQHIRMYDLNSNNPNPIISYDG 83 R+W + V+ +S V + P A ++++ + I ++ Sbjct: 25 RYW--RQYTSAQLVKEHNS-VTHISFNPQHPHDFAVTSSTRVQIFSSRTRQV--IKTFSR 79 Query: 84 VNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHP-NQAE 142 + S F DG+ + G ++D + I P + H + Sbjct: 80 FKDVVYSASFRSDGKLLCAGDATGLVSVYDSYNPRTILLSINASTHPTHVTKFHTQDNKI 139 Query: 143 LIVGDQSGAIHIWDLKTDHNEQL-IPEPEVSITSAHIDPDAS-YMAAVNSTGNCYVWNLT 200 L +WD+ + QL + + + P A +A + G +++ Sbjct: 140 LATASDDRVTRLWDISNAYEPQLELTGATDYVRTLSFIPAAPHLVATGSYDGLIRLYDTR 199 Query: 201 GGIGDEVTQLIPKTKIPAHTRYA-LQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELS 259 + L H + SP T + +C + K+W ++ + E Sbjct: 200 SSGSTPIYSL-------NHDQPVENVIAVSP--TQIVSCGGNNF-KVWDLTSNKKLYERG 249 Query: 260 IKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLA 319 + + S ++ +S D +++ + V+ A Sbjct: 250 NFNKAVTCLDYVENFD---SPMQSALIASSLDGHVKVFDPLDNFQVKFGWKFSGPVLSCA 306 Query: 320 FNDS 323 + S Sbjct: 307 VSPS 310 Score = 82.1 bits (201), Expect = 3e-16, Method: Composition-based stats. Identities = 42/198 (21%), Positives = 72/198 (36%), Gaps = 16/198 (8%) Query: 11 DPVILATAGYDHTVRFWQAHS-GICTRTVQHQDSQVNALEVTPDRSMIAAAG--YQHIRM 67 D ILATA D R W + + V L P + A G IR+ Sbjct: 136 DNKILATASDDRVTRLWDISNAYEPQLELTGATDYVRTLSFIPAAPHLVATGSYDGLIRL 195 Query: 68 YDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQV 127 YD S+ PI S ++ + +V + + GG ++WDL + N + Sbjct: 196 YDTRSSGSTPIYSL-NHDQPVENVIAVSPTQIVSCGG--NNFKVWDL-TSNKKLYERGNF 251 Query: 128 NAPINCVCL-----HPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPD- 181 N + C+ P Q+ LI G + ++D + + + + S + P Sbjct: 252 NKAVTCLDYVENFDSPMQSALIASSLDGHVKVFDPLDNFQVKFGWKFSGPVLSCAVSPST 311 Query: 182 ---ASYMAAVNSTGNCYV 196 ++ A S+G + Sbjct: 312 AQGNRHLVAGLSSGLLAI 329 Score = 73.6 bits (179), Expect = 1e-13, Method: Composition-based stats. Identities = 38/229 (16%), Positives = 81/229 (35%), Gaps = 22/229 (9%) Query: 12 PVILATAGYDHTVRFWQAHS--GICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYD 69 P ++AT YD +R + S ++ H N + V+P + I + G + +++D Sbjct: 181 PHLVATGSYDGLIRLYDTRSSGSTPIYSLNHDQPVENVIAVSP--TQIVSCGGNNFKVWD 238 Query: 70 LNSNNPNPIISYDGVNKNIASVGF-----HEDGRWMYTGGEDCTARIWDLRSRNLQCQRI 124 L SN + NK + + + + D +++D N Q + Sbjct: 239 LTSNK--KLYERGNFNKAVTCLDYVENFDSPMQSALIASSLDGHVKVFDPLD-NFQVKFG 295 Query: 125 FQVNAPINCVCLHPNQAE----LIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDP 180 ++ + P+ + P+ A+ L+ G SG + I K + S Sbjct: 296 WKFSGPVLSCAVSPSTAQGNRHLVAGLSSGLLAIRTKKKEKRSSDKENAPASFNKNAKSN 355 Query: 181 DASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFS 229 + M + + ++ + ++ A R Q ++S Sbjct: 356 NFQRMMRGSE------YQGDQEHIIHNDKVRSQRRMRAFERNINQFKWS 398 >5CXB-B nrPDB Length = 369 Score = 94.1 bits (232), Expect = 7e-20, Method: Composition-based stats. Identities = 66/352 (18%), Positives = 116/352 (32%), Gaps = 70/352 (19%) Query: 7 TVGSDP--VILATAGYDHTVRFWQAHSGICTRTVQ-HQDSQVNALEVTP--DRSMIAAAG 61 +V DP V LAT G D TVR W+ +G +V+ + D VN + P D ++AAA Sbjct: 26 SVAIDPTGVALATGGDDGTVRVWELLTGRQVWSVKLNGDEAVNTVRWRPTKDTFILAAAA 85 Query: 62 YQHIRM-----------YDLNSNN------------------------------PNPIIS 80 + I + D S + P + Sbjct: 86 GEDIFLMIPTHPSVTPALDQASRDILNAGFGHATNGKQQANLPPGKEPPGKWARPGTRLE 145 Query: 81 YDGV------NKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRI--FQVNAPIN 132 +GV I ++ +H G T + + + +I ++N Sbjct: 146 DEGVLLRITVRSTIKAISWHRRGDHFATVSPSGQRSSVAIHTLSKHLTQIPFRKLNGLAQ 205 Query: 133 CVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTG 192 HP + V Q +I +DL+ +++ I+S + P + + Sbjct: 206 TASFHPLRPLFFVATQ-RSIRCYDLQKLELVKIVQPGAKWISSFDVHPGGDNLVVGSYDK 264 Query: 193 NCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDS-TLLATCSADQTCKIW---- 247 +W+ D P + HT RF L A S D + +I+ Sbjct: 265 RL-LWH------DLDLSNRPYKTMRFHTEAIRAVRFHKGGLPLFADASDDGSLQIFHGKV 317 Query: 248 --RTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLW 297 + + + G+ + G + + + V+A +D ARLW Sbjct: 318 PNDQLENPTIVPVKMLKGHKVVNKLG-VLDIDWHPREPWCVSAGADGTARLW 368 Score = 69.0 bits (167), Expect = 3e-12, Method: Composition-based stats. Identities = 35/208 (16%), Positives = 60/208 (28%), Gaps = 33/208 (15%) Query: 15 LATAGYDHTVRFWQAHSGICTRTVQHQDSQV---------NALEVTPDRSMIAAAGYQHI 65 AT S + T+ +Q+ P R + A + I Sbjct: 171 FATVSPSG------QRSSVAIHTLSKHLTQIPFRKLNGLAQTASFHPLRPLFFVATQRSI 224 Query: 66 RMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIW-DLRSRNLQCQRI 124 R YDL I+ K I+S H G + G D +W DL N + + Sbjct: 225 RCYDLQKLELVKIV--QPGAKWISSFDVHPGGDNLVVGSYDKRL-LWHDLDLSNRPYKTM 281 Query: 125 FQVNAPINCVCLHPNQ-AELIVGDQSGAIHIWDLKTDH---------NEQLIPEPEVS-- 172 I V H G++ I+ K + +++ +V Sbjct: 282 RFHTEAIRAVRFHKGGLPLFADASDDGSLQIFHGKVPNDQLENPTIVPVKMLKGHKVVNK 341 Query: 173 --ITSAHIDPDASYMAAVNSTGNCYVWN 198 + P + + + G +W Sbjct: 342 LGVLDIDWHPREPWCVSAGADGTARLWM 369 Score = 67.1 bits (162), Expect = 1e-11, Method: Composition-based stats. Identities = 42/290 (14%), Positives = 81/290 (27%), Gaps = 59/290 (20%) Query: 81 YDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQ 140 + G + SV G + TGG+D T R+W+L + + +N V P + Sbjct: 17 FRGHEGRVRSVAIDPTGVALATGGDDGTVRVWELLTGRQVWSVKLNGDEAVNTVRWRPTK 76 Query: 141 AELIVGDQSGA-IHIW----------------DLKTDHNEQLIPEPEVSITSAHIDPDAS 183 I+ +G I + D+ + + +P Sbjct: 77 DTFILAAAAGEDIFLMIPTHPSVTPALDQASRDILNAGFGHATNGKQQANLPPGKEPPGK 136 Query: 184 YM--------------AAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHT--------- 220 + V ST W+ G V+ ++ + HT Sbjct: 137 WARPGTRLEDEGVLLRITVRSTIKAISWHRRGDHFATVSPSGQRSSVAIHTLSKHLTQIP 196 Query: 221 -----RYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWG 275 A F P L + ++ + + L+ + + W+ Sbjct: 197 FRKLNGLAQTASFHPLRPLFFVATQ-RSIRCYDLQKLELVKIVQPGA--------KWISS 247 Query: 276 CAFSGDSQYIVTASSDNLARLW---CVETGEIKREYGGHQKAVVCLAFND 322 +V S D LW + + H +A+ + F+ Sbjct: 248 FDVHPGGDNLVVGSYDKRL-LWHDLDLSN-RPYKTMRFHTEAIRAVRFHK 295 Score = 50.5 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 28/250 (11%), Positives = 61/250 (24%), Gaps = 51/250 (20%) Query: 117 RNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIP-EPEVSITS 175 +Q + V + P L G G + +W+L T + + ++ + Sbjct: 10 PTVQQTIFRGHEGRVRSVAIDPTGVALATGGDDGTVRVWELLTGRQVWSVKLNGDEAVNT 69 Query: 176 AHIDP-DASYMAAVNSTGNCYVW---------------------------------NLTG 201 P +++ A + + ++ NL Sbjct: 70 VRWRPTKDTFILAAAAGEDIFLMIPTHPSVTPALDQASRDILNAGFGHATNGKQQANLPP 129 Query: 202 GIGDEVTQLIPKTKIPA--------HTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFS 253 G P T++ + AT S + Sbjct: 130 GKEPPGKWARPGTRLEDEGVLLRITVRSTIKAISWHRRGDHFATVSPSGQ------RSSV 183 Query: 254 LMTELSIK-SGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQ 312 + LS + P G +F A + R + ++ E+ + Sbjct: 184 AIHTLSKHLTQIPFRKLNGLAQTASFHPLRPLFFVA-TQRSIRCYDLQKLELVKIVQPGA 242 Query: 313 KAVVCLAFND 322 K + + Sbjct: 243 KWISSFDVHP 252 Score = 43.6 bits (101), Expect = 1e-04, Method: Composition-based stats. Identities = 11/71 (15%), Positives = 21/71 (29%), Gaps = 3/71 (4%) Query: 255 MTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIK--REYGGHQ 312 + G + A + T D R+W + TG + G Sbjct: 6 LKPFPTVQQTIFRGHEGRVRSVAIDPTGVALATGGDDGTVRVWELLTGRQVWSVKLNG-D 64 Query: 313 KAVVCLAFNDS 323 +AV + + + Sbjct: 65 EAVNTVRWRPT 75 >2AQ5-A nrPDB Length = 402 Score = 91.0 bits (224), Expect = 7e-19, Method: Composition-based stats. Identities = 33/227 (14%), Positives = 63/227 (27%), Gaps = 26/227 (11%) Query: 83 GVNKNIASVGFHEDG-RWMYTGGEDCTARIWDLRSRNL------QCQRIFQVNAPINCVC 135 G + + + + +G EDCT +W++ L + + V Sbjct: 79 GHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKRVGIVA 138 Query: 136 LHPN-QAELIVGDQSGAIHIWDLKTDHNEQLI--PEPEVSITSAHIDPDASYMAAVNSTG 192 HP Q L+ I +WD+ T + +I S D + + Sbjct: 139 WHPTAQNVLLSAGCDNVILVWDVGTGAAVLTLGPDVHPDTIYSVDWSRDGALICTSCRDK 198 Query: 193 NCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATC---SADQTCKIWRT 249 V G + P H + + +L T +++ +W T Sbjct: 199 RVRVIEPRKGTVVAEKDRPHEGTRPVHAVFVS------EGKILTTGFSRMSERQVALWDT 252 Query: 250 SNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASS-DNLAR 295 L + + F D+ + D+ R Sbjct: 253 ------KHLEEPLSLQELDTSSGVLLPFFDPDTNIVYLCGKGDSSIR 293 Score = 90.2 bits (222), Expect = 1e-18, Method: Composition-based stats. Identities = 41/237 (17%), Positives = 82/237 (34%), Gaps = 26/237 (10%) Query: 2 NTSP----GTVGSDPVILATAGYDHTVRFWQAHSGICTR-------TVQHQDSQVNALEV 50 +T+P + ++A+ D TV W+ G T++ +V + Sbjct: 80 HTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKRVGIVAW 139 Query: 51 TPDRS--MIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCT 108 P +++A I ++D+ + + D I SV + DG + T D Sbjct: 140 HPTAQNVLLSAGCDNVILVWDVGTGAAVLTLGPDVHPDTIYSVDWSRDGALICTSCRDKR 199 Query: 109 ARIWDLRSRNLQCQ--RIFQVNAPINCVCLHPNQAELIVG---DQSGAIHIWDLKTDHNE 163 R+ + R + + R + P++ V L G + +WD T H E Sbjct: 200 VRVIEPRKGTVVAEKDRPHEGTRPVHAV-FVSEGKILTTGFSRMSERQVALWD--TKHLE 256 Query: 164 QLIPEPEVSITSAH----IDPDASYM-AAVNSTGNCYVWNLTGGIGDEVTQLIPKTK 215 + + E+ +S DPD + + + + +T + +K Sbjct: 257 EPLSLQELDTSSGVLLPFFDPDTNIVYLCGKGDSSIRYFEITSEAPFLHYLSMFSSK 313 Score = 84.0 bits (206), Expect = 8e-17, Method: Composition-based stats. Identities = 24/196 (12%), Positives = 53/196 (27%), Gaps = 24/196 (12%) Query: 120 QCQRIFQVNAPINCVCLHP-NQAELIVGDQSGAIHIWDLKTD-------HNEQLIPEPEV 171 + AP+ + P N + G + + +W++ + Sbjct: 73 NVPLVCGHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTK 132 Query: 172 SITSAHIDPDA-SYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSP 230 + P A + + + VW++ G H +S Sbjct: 133 RVGIVAWHPTAQNVLLSAGCDNVILVWDVGTGAAVLTLGP------DVHPDTIYSVDWSR 186 Query: 231 DSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTAS- 289 D L+ T D+ ++ +++ E F + + + T Sbjct: 187 DGALICTSCRDKRVRVIEPRKGTVVAEKDRPHEGTRPVHA------VFVSEGKILTTGFS 240 Query: 290 --SDNLARLWCVETGE 303 S+ LW + E Sbjct: 241 RMSERQVALWDTKHLE 256 Score = 81.7 bits (200), Expect = 4e-16, Method: Composition-based stats. Identities = 31/181 (17%), Positives = 59/181 (32%), Gaps = 14/181 (7%) Query: 134 VCLHPNQAELIV-GDQSGAIHIWDL----KTDHNEQLIPEPEVSITSAHIDP-DASYMAA 187 ++P LI GA + L + D N L+ + P + + +A+ Sbjct: 40 CAVNPKFMALICEASGGGAFLVLPLGKTGRVDKNVPLVCGHTAPVLDIAWCPHNDNVIAS 99 Query: 188 VNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPD-STLLATCSADQTCKI 246 + VW + G G + P + HT+ + P +L + D + Sbjct: 100 GSEDCTVMVWEIPDG-GLVLPLREPVITLEGHTKRVGIVAWHPTAQNVLLSAGCDNVILV 158 Query: 247 WRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKR 306 W + + L + ++ +S D I T+ D R+ G + Sbjct: 159 WDVGTGAAVLTLGP------DVHPDTIYSVDWSRDGALICTSCRDKRVRVIEPRKGTVVA 212 Query: 307 E 307 E Sbjct: 213 E 213 Score = 70.2 bits (170), Expect = 1e-12, Method: Composition-based stats. Identities = 23/108 (21%), Positives = 44/108 (40%), Gaps = 5/108 (4%) Query: 218 AHTRYALQCRFSP-DSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGC 276 HT L + P + ++A+ S D T +W + L+ L + E + Sbjct: 79 GHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLR-EPVITLEGHTKRVGIV 137 Query: 277 AFSGDSQ-YIVTASSDNLARLWCVETGEIKREYGG--HQKAVVCLAFN 321 A+ +Q +++A DN+ +W V TG G H + + ++ Sbjct: 138 AWHPTAQNVLLSAGCDNVILVWDVGTGAAVLTLGPDVHPDTIYSVDWS 185 Score = 45.5 bits (106), Expect = 3e-05, Method: Composition-based stats. Identities = 12/64 (18%), Positives = 22/64 (34%), Gaps = 8/64 (12%) Query: 268 SSRGWMWGCAFSG-DSQYIVTASSDNLARLWCVETG-------EIKREYGGHQKAVVCLA 319 + A+ + I + S D +W + G E GH K V +A Sbjct: 79 GHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKRVGIVA 138 Query: 320 FNDS 323 ++ + Sbjct: 139 WHPT 142 >5OQL-X nrPDB Length = 630 Score = 91.0 bits (224), Expect = 7e-19, Method: Composition-based stats. Identities = 38/286 (13%), Positives = 80/286 (27%), Gaps = 49/286 (17%) Query: 8 VGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAG-YQHIR 66 D + T G D + + A + V L + + + + ++ Sbjct: 254 ASQDGKFVVTGGADKRLVVYNAADLKPIKAFTQHRDAVTGLAFRRGTNQLYSCSKDRTVK 313 Query: 67 MYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQR--- 123 ++ L+ + + G I + R + G D TAR W + + R Sbjct: 314 VWSLD--ELAYVETLFGHQDEILDIDALGQERCVSVGARDRTARYWKVPEESQLVFRGGG 371 Query: 124 -------------------IFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQ 164 ++ V + + + G +G + +W ++ Sbjct: 372 EGGSSNTKKHKLPPGMDPASAAHEGSMDRVAM-IDDDMFVTGSDNGDLALWSIQRKKPLH 430 Query: 165 LIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYAL 224 +I + ++P + + + + P R Sbjct: 431 VIA------RAHGLEPP------------IKLEDYSADEIPD-----PSIIPAPQPRGIT 467 Query: 225 QCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSR 270 R P S L+ + S D ++WR S E G E+ Sbjct: 468 ALRTLPYSDLIFSGSWDGCIRVWRLSEDKRKLEAVGILGVGSETCE 513 Score = 82.9 bits (203), Expect = 2e-16, Method: Composition-based stats. Identities = 34/256 (13%), Positives = 69/256 (26%), Gaps = 36/256 (14%) Query: 79 ISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHP 138 +Y G K V +DG+++ TGG D +++ + Q + + Sbjct: 240 KTYQGHLKAPLVVKASQDGKFVVTGGADKRLVVYNAADLK-PIKAFTQHRDAVTGLAFRR 298 Query: 139 NQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWN 198 +L + + +W L + + + I ++ W Sbjct: 299 GTNQLYSCSKDRTVKVWSLDELAYVETLFGHQDEILDIDALGQERCVSVGARDRTARYWK 358 Query: 199 LTG-------GIGDEVTQLIPKTKIP--------AHTRYALQCRFSPDSTLLATCSADQT 243 + G G+ + K K+P AH + D + T S + Sbjct: 359 VPEESQLVFRGGGEGGSSNTKKHKLPPGMDPASAAHEGSMDRVA-MIDDDMFVTGSDNGD 417 Query: 244 CKIWRTSNFSLMTELSIKSGNP-------------------GESSRGWMWGCAFSGDSQY 284 +W + ++ G + S Sbjct: 418 LALWSIQRKKPLHVIARAHGLEPPIKLEDYSADEIPDPSIIPAPQPRGITALRTLPYSDL 477 Query: 285 IVTASSDNLARLWCVE 300 I + S D R+W + Sbjct: 478 IFSGSWDGCIRVWRLS 493 Score = 70.2 bits (170), Expect = 1e-12, Method: Composition-based stats. Identities = 24/197 (12%), Positives = 58/197 (29%), Gaps = 25/197 (12%) Query: 123 RIFQVNAPI-NCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPD 181 + +Q + V + ++ G + +++ + + ++T Sbjct: 240 KTYQGHLKAPLVVKASQDGKFVVTGGADKRLVVYNAADLKPIKAFTQHRDAVTGLAFRRG 299 Query: 182 ASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSAD 241 + + + + VW+L +L + H L ++ + D Sbjct: 300 TNQLYSCSKDRTVKVWSLD--------ELAYVETLFGHQDEILDIDALGQERCVSVGARD 351 Query: 242 QTCKIWRTSNFSLMT---------------ELSIKSGNPGESSRGWMWGCAFSGDSQYIV 286 +T + W+ S + +L + G M A D V Sbjct: 352 RTARYWKVPEESQLVFRGGGEGGSSNTKKHKLPPGMDPASAAHEGSMDRVAMIDD-DMFV 410 Query: 287 TASSDNLARLWCVETGE 303 T S + LW ++ + Sbjct: 411 TGSDNGDLALWSIQRKK 427 Score = 64.8 bits (156), Expect = 5e-11, Method: Composition-based stats. Identities = 27/185 (14%), Positives = 54/185 (29%), Gaps = 38/185 (20%) Query: 162 NEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVW---NLTGGIGDEVTQLIPK----- 213 ++TS + P Y G W +L + T+ PK Sbjct: 162 TYTQFRWNSGTVTSVAVCP--PYAYTTTKDGYLTKWKLQDLPKNQWPQTTKKKPKKPPAP 219 Query: 214 --------------------TKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFS 253 H + L + S D + T AD+ ++ ++ Sbjct: 220 PKKRPERICFAKADARKANDKTYQGHLKAPLVVKASQDGKFVVTGGADKRLVVYNAADLK 279 Query: 254 LMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQK 313 + + R + G AF + + + S D ++W ++ GHQ Sbjct: 280 PIKAFT--------QHRDAVTGLAFRRGTNQLYSCSKDRTVKVWSLDELAYVETLFGHQD 331 Query: 314 AVVCL 318 ++ + Sbjct: 332 EILDI 336 Score = 63.2 bits (152), Expect = 1e-10, Method: Composition-based stats. Identities = 22/138 (15%), Positives = 40/138 (28%), Gaps = 16/138 (11%) Query: 162 NEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTR 221 N++ + D ++ + V+N L P H Sbjct: 238 NDKTYQGHLKAPLVVKASQDGKFVVTGGADKRLVVYNAAD--------LKPIKAFTQHRD 289 Query: 222 YALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGD 281 F + L +CS D+T K+W + + L + + G Sbjct: 290 AVTGLAFRRGTNQLYSCSKDRTVKVWSLDELAYVETL--------FGHQDEILDIDALGQ 341 Query: 282 SQYIVTASSDNLARLWCV 299 + + + D AR W V Sbjct: 342 ERCVSVGARDRTARYWKV 359 >6EM1-m nrPDB Length = 807 Score = 90.2 bits (222), Expect = 1e-18, Method: Composition-based stats. Identities = 39/221 (17%), Positives = 78/221 (35%), Gaps = 17/221 (7%) Query: 85 NKNIASVGFHEDGRWMYTGGED--CTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAE 142 K + + +H G + T D T+ + S++L + I HP + + Sbjct: 594 KKTVKKLSWHRKGDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQ 653 Query: 143 LIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGG 202 L V Q + I+DL + + ++ I P + A + +W+ Sbjct: 654 LFVCSQ-RYVRIYDLSQQILVKKLLPGARWLSKIDIHPRGDNLIASSFDKRV-LWH---- 707 Query: 203 IGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIW------RTSNFSLMT 256 D P + H + F L ++ + D T ++ ++ Sbjct: 708 --DLDLASTPYKTLRYHEKAVRSVNFHKKLPLFSSAADDGTIHVFHATVYDDMMKNPMIV 765 Query: 257 ELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLW 297 L +G+ +S G + + ++ +A +DN ARLW Sbjct: 766 PLKKLTGHKVINSLG-VLDAIWHPREAWLFSAGADNTARLW 805 Score = 79.4 bits (194), Expect = 2e-15, Method: Composition-based stats. Identities = 32/213 (15%), Positives = 68/213 (31%), Gaps = 10/213 (4%) Query: 45 VNALEVTPDRSMIAAAGYQ--HIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYT 102 V L + + + + I FH ++ Sbjct: 597 VKKLSWHRKGDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFV 656 Query: 103 GGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLK-TDH 161 + RI+DL S+ + +++ ++ + +HP LI + DL Sbjct: 657 CSQ-RYVRIYDL-SQQILVKKLLPGARWLSKIDIHPRGDNLIASSFDKRVLWHDLDLAST 714 Query: 162 NEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVT-QLIPKTKIPAH- 219 + + E ++ S + ++ G +V++ T ++P K+ H Sbjct: 715 PYKTLRYHEKAVRSVNFHKKLPLFSSAADDGTIHVFHATVYDDMMKNPMIVPLKKLTGHK 774 Query: 220 ---TRYALQCRFSPDSTLLATCSADQTCKIWRT 249 + L + P L + AD T ++W T Sbjct: 775 VINSLGVLDAIWHPREAWLFSAGADNTARLWTT 807 Score = 78.3 bits (191), Expect = 5e-15, Method: Composition-based stats. Identities = 41/326 (12%), Positives = 104/326 (31%), Gaps = 54/326 (16%) Query: 34 CTRTVQHQDSQVNALEVTPDRSMIAAAGYQ-HIRMYDLNSNNPNPIISY----DGVNKNI 88 C+ +V L + P +A +R++++ + + + + +I Sbjct: 429 CSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHI 488 Query: 89 ASVGFHED---GRWMYTGGEDCTARI-----WDLR-SRNLQCQRIFQVNAPINC----VC 135 + ++ D G GE+ + +D+ + + + F + + Sbjct: 489 ECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLE 548 Query: 136 LHPNQAELIVGDQSG-----------AIHIWDLKTDHNEQ----LIPEPEVSITSAHIDP 180 ++ N GD+ G + W+ + + + + ++ Sbjct: 549 VNENGD----GDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHR 604 Query: 181 DASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSA 240 Y V T + +V++ + ++ + +F P L CS Sbjct: 605 KGDYFVTVQPDS-----GNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVCSQ 659 Query: 241 DQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLW-CV 299 + +I+ S L+ +L + W+ ++ +S D LW + Sbjct: 660 -RYVRIYDLSQQILVKKLLPGA--------RWLSKIDIHPRGDNLIASSFDKRV-LWHDL 709 Query: 300 ETGEI-KREYGGHQKAVVCLAFNDSV 324 + + H+KAV + F+ + Sbjct: 710 DLASTPYKTLRYHEKAVRSVNFHKKL 735 Score = 75.2 bits (183), Expect = 4e-14, Method: Composition-based stats. Identities = 23/193 (11%), Positives = 61/193 (31%), Gaps = 17/193 (8%) Query: 19 GYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLNSNNPNPI 78 + +V Q + + + + P + + +++R+YDL + + Sbjct: 616 SGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVCSQRYVRIYDL--SQQILV 673 Query: 79 ISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIW-DLRSRNLQCQRIFQVNAPINCVCLH 137 + ++ + H G + D +W DL + + + + V H Sbjct: 674 KKLLPGARWLSKIDIHPRGDNLIASSFDKRV-LWHDLDLASTPYKTLRYHEKAVRSVNFH 732 Query: 138 PNQAELIVGDQSGAIHIW------DLKTDH---NEQLIPEPEVS----ITSAHIDPDASY 184 G IH++ D+ + + + +V + A P ++ Sbjct: 733 KKLPLFSSAADDGTIHVFHATVYDDMMKNPMIVPLKKLTGHKVINSLGVLDAIWHPREAW 792 Query: 185 MAAVNSTGNCYVW 197 + + + +W Sbjct: 793 LFSAGADNTARLW 805 Score = 51.7 bits (122), Expect = 4e-07, Method: Composition-based stats. Identities = 14/93 (15%), Positives = 25/93 (26%), Gaps = 2/93 (2%) Query: 191 TGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTS 250 N + L + T H P LAT S D T ++W Sbjct: 408 DPNSLIPELPSPKDLRPFPIRCSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEIL 467 Query: 251 NFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQ 283 + + E+ + ++ D+ Sbjct: 468 TGREV--YRTTLIDDEENPDYHIECIEWNPDAN 498 Score = 43.2 bits (100), Expect = 1e-04, Method: Composition-based stats. Identities = 11/67 (16%), Positives = 21/67 (31%) Query: 241 DQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVE 300 D I + + I+ +G + + ++ T S D R+W + Sbjct: 408 DPNSLIPELPSPKDLRPFPIRCSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEIL 467 Query: 301 TGEIKRE 307 TG Sbjct: 468 TGREVYR 474 >5YZG-2 nrPDB Length = 646 Score = 90.2 bits (222), Expect = 1e-18, Method: Composition-based stats. Identities = 37/238 (15%), Positives = 78/238 (32%), Gaps = 28/238 (11%) Query: 41 QDSQVNALEVTPDRSMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWM 100 + + T +I A+ H++ + + + I S+ +G Sbjct: 89 HRDVITHVVCTKTDFIITASHDGHVKFWKKIEEGIEFVKHFRSHLGVIESIAVSSEGALF 148 Query: 101 YTGGEDCTARIWDLRSRNL-----------QCQRIFQVNAPINCVCLHPNQAELIVGDQS 149 + G+D +++D+ + ++ QC+ I+ I+ V Sbjct: 149 CSVGDDKAMKVFDVVNFDMINMLKLGYFPGQCEWIYCPGDAISSVAASEKST-------- 200 Query: 150 GAIHIWDLKTD-HNEQLIPE-PEVSITSAHIDPDASYMAAVNSTGNCYVW-------NLT 200 G I I+D + D + + +T ++P + + + +G W Sbjct: 201 GKIFIYDGRGDNQPLHIFDKLHTSPLTQIRLNPVYKAVVSSDKSGMIEYWTGPPHEYKFP 260 Query: 201 GGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTEL 258 + E + Y FSPD +AT +D+ +I+R LM Sbjct: 261 KNVNWEYKTDTDLYEFAKCKAYPTSVCFSPDGKKIATIGSDRKVRIFRFVTGKLMRVF 318 Score = 84.4 bits (207), Expect = 6e-17, Method: Composition-based stats. Identities = 36/238 (15%), Positives = 72/238 (30%), Gaps = 19/238 (7%) Query: 84 VNKNIASVGFHEDGRWMYTGGEDCTARIWD-LRSRNLQCQRIFQVNAPINCVCLHPNQAE 142 I V + ++ T D + W + + I + + A Sbjct: 89 HRDVITHVVCTK-TDFIITASHDGHVKFWKKIEEGIEFVKHFRSHLGVIESIAVSSEGAL 147 Query: 143 LIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITS-AHIDPD---ASYMAAVNSTGNCYVWN 198 A+ ++D+ ++ P +S A+ STG ++++ Sbjct: 148 FCSVGDDKAMKVFDVVNFDMINMLKLGYFPGQCEWIYCPGDAISSVAASEKSTGKIFIYD 207 Query: 199 LTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTEL 258 G GD I HT Q R +P + + + W Sbjct: 208 ---GRGDNQPLHIFDKL---HTSPLTQIRLNPVYKAVVSSDKSGMIEYWTGPPHEYKFPK 261 Query: 259 SIKSGNPGESS-------RGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYG 309 ++ ++ + + FS D + I T SD R++ TG++ R + Sbjct: 262 NVNWEYKTDTDLYEFAKCKAYPTSVCFSPDGKKIATIGSDRKVRIFRFVTGKLMRVFD 319 Score = 74.4 bits (181), Expect = 7e-14, Method: Composition-based stats. Identities = 41/226 (18%), Positives = 82/226 (36%), Gaps = 27/226 (11%) Query: 7 TVGSDPVILATAGYDHTVRFW-QAHSGIC-TRTVQHQDSQVNALEVTPDRSMIAAAGYQH 64 V + + TA +D V+FW + GI + + + ++ V+ + ++ + G Sbjct: 96 VVCTKTDFIITASHDGHVKFWKKIEEGIEFVKHFRSHLGVIESIAVSSEGALFCSVGDDK 155 Query: 65 -IRMYD---LNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIW--DLRSRN 118 ++++D + N + + G + I D E T +I+ D R N Sbjct: 156 AMKVFDVVNFDMINMLKLGYFPGQCEWIYC---PGDAISSVAASEKSTGKIFIYDGRGDN 212 Query: 119 LQCQRIFQ-VNAPINCVCLHPNQAELIVGDQSGAIHI---------------WDLKTDHN 162 + +P+ + L+P ++ D+SG I W+ KTD + Sbjct: 213 QPLHIFDKLHTSPLTQIRLNPVYKAVVSSDKSGMIEYWTGPPHEYKFPKNVNWEYKTDTD 272 Query: 163 EQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVT 208 + + TS PD +A + S ++ G V Sbjct: 273 LYEFAKCKAYPTSVCFSPDGKKIATIGSDRKVRIFRFVTGKLMRVF 318 >6C0F-s nrPDB Length = 807 Score = 89.8 bits (221), Expect = 2e-18, Method: Composition-based stats. Identities = 39/221 (17%), Positives = 78/221 (35%), Gaps = 17/221 (7%) Query: 85 NKNIASVGFHEDGRWMYTGGED--CTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAE 142 K + + +H G + T D T+ + S++L + I HP + + Sbjct: 594 KKTVKKLSWHRKGDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQ 653 Query: 143 LIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGG 202 L V Q + I+DL + + ++ I P + A + +W+ Sbjct: 654 LFVCSQ-RYVRIYDLSQQILVKKLLPGARWLSKIDIHPRGDNLIASSFDKRV-LWH---- 707 Query: 203 IGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIW------RTSNFSLMT 256 D P + H + F L ++ + D T ++ ++ Sbjct: 708 --DLDLASTPYKTLRYHEKAVRSVNFHKKLPLFSSAADDGTIHVFHATVYDDMMKNPMIV 765 Query: 257 ELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLW 297 L +G+ +S G + + ++ +A +DN ARLW Sbjct: 766 PLKKLTGHKVINSLG-VLDAIWHPREAWLFSAGADNTARLW 805 Score = 78.7 bits (192), Expect = 3e-15, Method: Composition-based stats. Identities = 32/213 (15%), Positives = 68/213 (31%), Gaps = 10/213 (4%) Query: 45 VNALEVTPDRSMIAAAGYQ--HIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYT 102 V L + + + + I FH ++ Sbjct: 597 VKKLSWHRKGDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFV 656 Query: 103 GGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLK-TDH 161 + RI+DL S+ + +++ ++ + +HP LI + DL Sbjct: 657 CSQ-RYVRIYDL-SQQILVKKLLPGARWLSKIDIHPRGDNLIASSFDKRVLWHDLDLAST 714 Query: 162 NEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVT-QLIPKTKIPAH- 219 + + E ++ S + ++ G +V++ T ++P K+ H Sbjct: 715 PYKTLRYHEKAVRSVNFHKKLPLFSSAADDGTIHVFHATVYDDMMKNPMIVPLKKLTGHK 774 Query: 220 ---TRYALQCRFSPDSTLLATCSADQTCKIWRT 249 + L + P L + AD T ++W T Sbjct: 775 VINSLGVLDAIWHPREAWLFSAGADNTARLWTT 807 Score = 77.1 bits (188), Expect = 9e-15, Method: Composition-based stats. Identities = 41/326 (12%), Positives = 104/326 (31%), Gaps = 54/326 (16%) Query: 34 CTRTVQHQDSQVNALEVTPDRSMIAAAGYQ-HIRMYDLNSNNPNPIISY----DGVNKNI 88 C+ +V L + P +A +R++++ + + + + +I Sbjct: 429 CSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHI 488 Query: 89 ASVGFHED---GRWMYTGGEDCTARI-----WDLR-SRNLQCQRIFQVNAPINC----VC 135 + ++ D G GE+ + +D+ + + + F + + Sbjct: 489 ECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLE 548 Query: 136 LHPNQAELIVGDQSG-----------AIHIWDLKTDHNEQ----LIPEPEVSITSAHIDP 180 ++ N GD+ G + W+ + + + + ++ Sbjct: 549 VNENGD----GDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHR 604 Query: 181 DASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSA 240 Y V T + +V++ + ++ + +F P L CS Sbjct: 605 KGDYFVTVQPDS-----GNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVCSQ 659 Query: 241 DQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLW-CV 299 + +I+ S L+ +L + W+ ++ +S D LW + Sbjct: 660 -RYVRIYDLSQQILVKKLLPGA--------RWLSKIDIHPRGDNLIASSFDKRV-LWHDL 709 Query: 300 ETGEI-KREYGGHQKAVVCLAFNDSV 324 + + H+KAV + F+ + Sbjct: 710 DLASTPYKTLRYHEKAVRSVNFHKKL 735 Score = 74.8 bits (182), Expect = 5e-14, Method: Composition-based stats. Identities = 23/193 (11%), Positives = 61/193 (31%), Gaps = 17/193 (8%) Query: 19 GYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLNSNNPNPI 78 + +V Q + + + + P + + +++R+YDL + + Sbjct: 616 SGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVCSQRYVRIYDL--SQQILV 673 Query: 79 ISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIW-DLRSRNLQCQRIFQVNAPINCVCLH 137 + ++ + H G + D +W DL + + + + V H Sbjct: 674 KKLLPGARWLSKIDIHPRGDNLIASSFDKRV-LWHDLDLASTPYKTLRYHEKAVRSVNFH 732 Query: 138 PNQAELIVGDQSGAIHIW------DLKTDH---NEQLIPEPEVS----ITSAHIDPDASY 184 G IH++ D+ + + + +V + A P ++ Sbjct: 733 KKLPLFSSAADDGTIHVFHATVYDDMMKNPMIVPLKKLTGHKVINSLGVLDAIWHPREAW 792 Query: 185 MAAVNSTGNCYVW 197 + + + +W Sbjct: 793 LFSAGADNTARLW 805 Score = 51.3 bits (121), Expect = 5e-07, Method: Composition-based stats. Identities = 14/93 (15%), Positives = 25/93 (26%), Gaps = 2/93 (2%) Query: 191 TGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTS 250 N + L + T H P LAT S D T ++W Sbjct: 408 DPNSLIPELPSPKDLRPFPIRCSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEIL 467 Query: 251 NFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQ 283 + + E+ + ++ D+ Sbjct: 468 TGREV--YRTTLIDDEENPDYHIECIEWNPDAN 498 Score = 43.2 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 11/67 (16%), Positives = 21/67 (31%) Query: 241 DQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVE 300 D I + + I+ +G + + ++ T S D R+W + Sbjct: 408 DPNSLIPELPSPKDLRPFPIRCSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEIL 467 Query: 301 TGEIKRE 307 TG Sbjct: 468 TGREVYR 474 >6CB1-s nrPDB Length = 569 Score = 89.4 bits (220), Expect = 2e-18, Method: Composition-based stats. Identities = 39/221 (17%), Positives = 78/221 (35%), Gaps = 17/221 (7%) Query: 85 NKNIASVGFHEDGRWMYTGGED--CTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAE 142 K + + +H G + T D T+ + S++L + I HP + + Sbjct: 356 KKTVKKLSWHRKGDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQ 415 Query: 143 LIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGG 202 L V Q + I+DL + + ++ I P + A + +W+ Sbjct: 416 LFVCSQ-RYVRIYDLSQQILVKKLLPGARWLSKIDIHPRGDNLIASSFDKRV-LWH---- 469 Query: 203 IGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIW------RTSNFSLMT 256 D P + H + F L ++ + D T ++ ++ Sbjct: 470 --DLDLASTPYKTLRYHEKAVRSVNFHKKLPLFSSAADDGTIHVFHATVYDDMMKNPMIV 527 Query: 257 ELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLW 297 L +G+ +S G + + ++ +A +DN ARLW Sbjct: 528 PLKKLTGHKVINSLG-VLDAIWHPREAWLFSAGADNTARLW 567 Score = 78.7 bits (192), Expect = 3e-15, Method: Composition-based stats. Identities = 32/213 (15%), Positives = 68/213 (31%), Gaps = 10/213 (4%) Query: 45 VNALEVTPDRSMIAAAGYQ--HIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYT 102 V L + + + + I FH ++ Sbjct: 359 VKKLSWHRKGDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFV 418 Query: 103 GGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLK-TDH 161 + RI+DL S+ + +++ ++ + +HP LI + DL Sbjct: 419 CSQ-RYVRIYDL-SQQILVKKLLPGARWLSKIDIHPRGDNLIASSFDKRVLWHDLDLAST 476 Query: 162 NEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVT-QLIPKTKIPAH- 219 + + E ++ S + ++ G +V++ T ++P K+ H Sbjct: 477 PYKTLRYHEKAVRSVNFHKKLPLFSSAADDGTIHVFHATVYDDMMKNPMIVPLKKLTGHK 536 Query: 220 ---TRYALQCRFSPDSTLLATCSADQTCKIWRT 249 + L + P L + AD T ++W T Sbjct: 537 VINSLGVLDAIWHPREAWLFSAGADNTARLWTT 569 Score = 77.1 bits (188), Expect = 9e-15, Method: Composition-based stats. Identities = 41/326 (12%), Positives = 104/326 (31%), Gaps = 54/326 (16%) Query: 34 CTRTVQHQDSQVNALEVTPDRSMIAAAGYQ-HIRMYDLNSNNPNPIISY----DGVNKNI 88 C+ +V L + P +A +R++++ + + + + +I Sbjct: 191 CSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHI 250 Query: 89 ASVGFHED---GRWMYTGGEDCTARI-----WDLR-SRNLQCQRIFQVNAPINC----VC 135 + ++ D G GE+ + +D+ + + + F + + Sbjct: 251 ECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLE 310 Query: 136 LHPNQAELIVGDQSG-----------AIHIWDLKTDHNEQ----LIPEPEVSITSAHIDP 180 ++ N GD+ G + W+ + + + + ++ Sbjct: 311 VNENGD----GDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHR 366 Query: 181 DASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSA 240 Y V T + +V++ + ++ + +F P L CS Sbjct: 367 KGDYFVTVQPDS-----GNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVCSQ 421 Query: 241 DQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLW-CV 299 + +I+ S L+ +L + W+ ++ +S D LW + Sbjct: 422 -RYVRIYDLSQQILVKKLLPGA--------RWLSKIDIHPRGDNLIASSFDKRV-LWHDL 471 Query: 300 ETGEI-KREYGGHQKAVVCLAFNDSV 324 + + H+KAV + F+ + Sbjct: 472 DLASTPYKTLRYHEKAVRSVNFHKKL 497 Score = 74.4 bits (181), Expect = 5e-14, Method: Composition-based stats. Identities = 23/193 (11%), Positives = 61/193 (31%), Gaps = 17/193 (8%) Query: 19 GYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLNSNNPNPI 78 + +V Q + + + + P + + +++R+YDL + + Sbjct: 378 SGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVCSQRYVRIYDL--SQQILV 435 Query: 79 ISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIW-DLRSRNLQCQRIFQVNAPINCVCLH 137 + ++ + H G + D +W DL + + + + V H Sbjct: 436 KKLLPGARWLSKIDIHPRGDNLIASSFDKRV-LWHDLDLASTPYKTLRYHEKAVRSVNFH 494 Query: 138 PNQAELIVGDQSGAIHIW------DLKTDH---NEQLIPEPEVS----ITSAHIDPDASY 184 G IH++ D+ + + + +V + A P ++ Sbjct: 495 KKLPLFSSAADDGTIHVFHATVYDDMMKNPMIVPLKKLTGHKVINSLGVLDAIWHPREAW 554 Query: 185 MAAVNSTGNCYVW 197 + + + +W Sbjct: 555 LFSAGADNTARLW 567 Score = 51.3 bits (121), Expect = 5e-07, Method: Composition-based stats. Identities = 14/93 (15%), Positives = 25/93 (26%), Gaps = 2/93 (2%) Query: 191 TGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTS 250 N + L + T H P LAT S D T ++W Sbjct: 170 DPNSLIPELPSPKDLRPFPIRCSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEIL 229 Query: 251 NFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQ 283 + + E+ + ++ D+ Sbjct: 230 TGREV--YRTTLIDDEENPDYHIECIEWNPDAN 260 Score = 42.8 bits (99), Expect = 2e-04, Method: Composition-based stats. Identities = 11/67 (16%), Positives = 21/67 (31%) Query: 241 DQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVE 300 D I + + I+ +G + + ++ T S D R+W + Sbjct: 170 DPNSLIPELPSPKDLRPFPIRCSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEIL 229 Query: 301 TGEIKRE 307 TG Sbjct: 230 TGREVYR 236 >5OV3-A nrPDB Length = 381 Score = 88.7 bits (218), Expect = 3e-18, Method: Composition-based stats. Identities = 49/298 (16%), Positives = 91/298 (30%), Gaps = 24/298 (8%) Query: 12 PVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHI-RMYDL 70 +LA D + W + + + V +L + D + +A +I +D+ Sbjct: 37 GTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDV 96 Query: 71 NSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAP 130 S + + + I V +H + +A + S + ++ Sbjct: 97 LSGDCDQRFRF---PSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSD 153 Query: 131 INCV-CLHPNQAELIVGDQSGAIHIW-----DLKTDHNEQLIPEPEVSITSAHIDPDASY 184 +N V + G+ G I + DL +I S S Sbjct: 154 LNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSC 213 Query: 185 MAAVNSTGNCYVWN----LTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSA 240 + V++ LT G E + + T + +C FS D + SA Sbjct: 214 FLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPW-KKCCFSGDGEYIVAGSA 272 Query: 241 -DQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLW 297 IW S +L+ L G + A+ I + SS + +W Sbjct: 273 RQHALYIWEKSIGNLVKILHGTRGEL-------LLDVAWHPVRPIIASISS-GVVSIW 322 Score = 68.6 bits (166), Expect = 3e-12, Method: Composition-based stats. Identities = 28/201 (13%), Positives = 60/201 (29%), Gaps = 38/201 (18%) Query: 133 CVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTG 192 + L VG G I IWD T ++I + S D + + ++ Sbjct: 30 TCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDN 89 Query: 193 NCYVWNLTGGIGDEVTQL-IPKTKIPAHTRYALQCRFSP--------------------- 230 W++ G D+ + P K+ H R + P Sbjct: 90 IVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVD 149 Query: 231 -------------DSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCA 277 + T +A + +T + L+ + +G ++ + Sbjct: 150 DDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTA---IKSIE 206 Query: 278 FSGDSQYIVTASSDNLARLWC 298 F+ + ++D + R++ Sbjct: 207 FARKGSCFLINTADRIIRVYD 227 Score = 38.6 bits (88), Expect = 0.004, Method: Composition-based stats. Identities = 9/62 (14%), Positives = 18/62 (29%) Query: 260 IKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLA 319 + + C F+ + +D +W T I + H V L Sbjct: 15 PEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLC 74 Query: 320 FN 321 ++ Sbjct: 75 WS 76 >3JZG-A nrPDB Length = 402 Score = 88.3 bits (217), Expect = 4e-18, Method: Composition-based stats. Identities = 42/302 (13%), Positives = 92/302 (30%), Gaps = 30/302 (9%) Query: 8 VGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTP-DRSMIAAAGYQH-I 65 + +LA AG +R + C + + +N L+ P D +++ + H + Sbjct: 117 SNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHAL 176 Query: 66 RMYDLNSNNPNPIISY-DGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRI 124 R++++ ++ I +G + S + G + + G D + ++W + S+ + Sbjct: 177 RLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIK 236 Query: 125 FQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASY 184 + +PN+ Q IH D T + Sbjct: 237 ESYDY-------NPNKTNRPFISQ--KIHFPDFSTRDI------HRNYVDCVRW--LGDL 279 Query: 185 MAAVNSTGNCYVW------NLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPD--STLLA 236 + + + W + I + + + RFS D +LA Sbjct: 280 ILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLA 339 Query: 237 TCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARL 296 + +W + + + +FS DS ++ D Sbjct: 340 LGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAA--IRQTSFSRDSSILIAVCDDASIWR 397 Query: 297 WC 298 W Sbjct: 398 WD 399 Score = 51.7 bits (122), Expect = 4e-07, Method: Composition-based stats. Identities = 27/203 (13%), Positives = 64/203 (31%), Gaps = 29/203 (14%) Query: 118 NLQCQRIFQ--VNAPINCVCLH----PNQAELIVGDQSGAIHIWDLKTDHNEQLIPEP-- 169 + +C + N P+ V + + S + +++ + +L+ Sbjct: 42 SFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVD 101 Query: 170 ---EVSITSAHIDPDA----SYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRY 222 + + + D+ +A S G + N + H Sbjct: 102 ADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPIT--------MQCIKHYVGHGNA 153 Query: 223 ALQCRFSP-DSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGD 281 + +F P D LL + S D ++W +L+ E R + + Sbjct: 154 INELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGG-----VEGHRDEVLSADYDLL 208 Query: 282 SQYIVTASSDNLARLWCVETGEI 304 + I++ D+ +LW + + + Sbjct: 209 GEKIMSCGMDHSLKLWRINSKRM 231 Score = 46.7 bits (109), Expect = 2e-05, Method: Composition-based stats. Identities = 22/177 (12%), Positives = 48/177 (27%), Gaps = 24/177 (13%) Query: 158 KTDHNEQLIPE-PEVSITSAHIDP----DASYMAAVNSTGNCYVWNLTGGIGDEVTQLIP 212 + + E + + + A + ++ + Q Sbjct: 41 YSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYV 100 Query: 213 KTKIPAHTRYALQCRFSPDST----LLATCSADQTCKIWRTSNFSLMTELSIKSGNPGES 268 C ++ DS LLA + +I + E Sbjct: 101 DADAD---ENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINE- 156 Query: 269 SRGWMWGCAFSG-DSQYIVTASSDNLARLWCVETGEIKREY---GGHQKAVVCLAFN 321 F D +++ S D+ RLW ++T + + GH+ V+ ++ Sbjct: 157 -------LKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYD 206 Score = 37.8 bits (86), Expect = 0.006, Method: Composition-based stats. Identities = 19/114 (16%), Positives = 39/114 (34%), Gaps = 11/114 (9%) Query: 217 PAHTRYALQCRFSPDST----LLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGW 272 H + +F+ S L+ ++ + E+ + + Sbjct: 51 EDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQ---GEIRLLQSYVDADADEN 107 Query: 273 MWGCAFSGDSQY----IVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFND 322 + CA++ DS + A S + R+ T + + Y GH A+ L F+ Sbjct: 108 FYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHP 161 >5CXC-A nrPDB Length = 510 Score = 88.3 bits (217), Expect = 4e-18, Method: Composition-based stats. Identities = 43/345 (12%), Positives = 97/345 (28%), Gaps = 69/345 (20%) Query: 15 LATAGYDHTVRFWQAHSGI----CTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMY-- 68 + +A YD +R W A + + + + + A + + +A + +R++ Sbjct: 161 VLSASYDGLLRIWNASGSVIATSPSGSHGGHTASIKAAKFLTSDRLASAGMDRTVRVWKY 220 Query: 69 ---DLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIW--------DLRSR 117 D + P + G ++ + + + T D W + + Sbjct: 221 TESDHFTGELKPTLELYGHTGSVDWLDVDGHSKHILTASADGAIGFWSASKASAPEPDAS 280 Query: 118 NLQCQRIFQ---------------------VNAPINCVCLHPNQAELI-VGDQSGAIHIW 155 L + + AP P + Q + Sbjct: 281 LLPGAHVSKRRKATSSVSTAQRGPLGLWSIHTAPATAAIFDPRDRTVAYSASQDHTVRTL 340 Query: 156 DLKTDHNEQLIP--EPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPK 213 DL T + P +S+++ S + A ++ ++T + Sbjct: 341 DLTTGQVVSTLTLTHPLLSLSALTRAGTTSPLLAAGTSAR----HITMVDPRASSATTSV 396 Query: 214 TKIPAHTRYALQCRFSPDSTL-LATCSADQTCKIWRTSNFSLMTELSIKSG--------- 263 + H + SP++ L + S D TC++W + T+ G Sbjct: 397 MTLRGHANKVVSLSPSPENEYSLVSGSHDGTCRVWDLRSVRPATKEEGSLGGVSEPVYVI 456 Query: 264 ------------NPGESSRGWMWGCAFSGDSQYIVTASSDNLARL 296 P ++ + D I + D ++ Sbjct: 457 ERESWASKGKKKRPVAGDGCKVFSVVW--DKLGIFSGGEDKKVQV 499 Score = 82.1 bits (201), Expect = 3e-16, Method: Composition-based stats. Identities = 39/206 (18%), Positives = 72/206 (34%), Gaps = 26/206 (12%) Query: 1 MNTSPGTVG----SDPVILATAGYDHTVRFWQAHSGICTR--TVQHQDSQVNALEVTPDR 54 ++T+P T D + +A DHTVR +G T+ H ++AL Sbjct: 310 IHTAPATAAIFDPRDRTVAYSASQDHTVRTLDLTTGQVVSTLTLTHPLLSLSALTRAGTT 369 Query: 55 SMIAAAGY--QHIRMYDLN-SNNPNPIISYDGVNKNIASVGFHEDGRW-MYTGGEDCTAR 110 S + AAG +HI M D S+ +++ G + S+ + + + +G D T R Sbjct: 370 SPLLAAGTSARHITMVDPRASSATTSVMTLRGHANKVVSLSPSPENEYSLVSGSHDGTCR 429 Query: 111 IWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPE 170 +WDLRS + + V + ++ ++ + Sbjct: 430 VWDLRSVRPATKEEGSLGGVSEPVYVIERESW--------------ASKGKKKRPVAGDG 475 Query: 171 VSITSAHIDPDASYMAAVNSTGNCYV 196 + S D + + V Sbjct: 476 CKVFSVVWDKLG--IFSGGEDKKVQV 499 Score = 74.0 bits (180), Expect = 9e-14, Method: Composition-based stats. Identities = 43/284 (15%), Positives = 89/284 (31%), Gaps = 39/284 (13%) Query: 52 PDRSMIAAAGYQHI-RMYDLNSN--NPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCT 108 P + + +A Y + R+++ + + +P S+ G +I + F R + + G D T Sbjct: 156 PGQERVLSASYDGLLRIWNASGSVIATSPSGSHGGHTASIKAAKFLTSDR-LASAGMDRT 214 Query: 109 ARIWD------LRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHN 162 R+W ++ ++ + + + ++ GAI W Sbjct: 215 VRVWKYTESDHFTGELKPTLELYGHTGSVDWLDVDGHSKHILTASADGAIGFWSASK--- 271 Query: 163 EQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRY 222 ++ +PDAS + + + Q P HT Sbjct: 272 ------------ASAPEPDASLLPGAHVSKRRK-----ATSSVSTAQRGPLGLWSIHTAP 314 Query: 223 ALQCRFSPDSTLLA-TCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGD 281 A F P +A + S D T + + +++ L++ S+ Sbjct: 315 ATAAIFDPRDRTVAYSASQDHTVRTLDLTTGQVVSTLTLTHPLLSLSALTRA-----GTT 369 Query: 282 SQYIVTASSDNLARLWCVETGE---IKREYGGHQKAVVCLAFND 322 S + +S + GH VV L+ + Sbjct: 370 SPLLAAGTSARHITMVDPRASSATTSVMTLRGHANKVVSLSPSP 413 >5FA5-B nrPDB Length = 367 Score = 87.5 bits (215), Expect = 6e-18, Method: Composition-based stats. Identities = 37/296 (12%), Positives = 87/296 (29%), Gaps = 31/296 (10%) Query: 42 DSQVNALEVTPDRSMIAAAGYQHIRMY--DLNSNNPNPIISYDGV-------NKNIASVG 92 + Q+ A D +++ A R + L +G +A + Sbjct: 53 ERQLEAARYRSDGALLLGASSLSGRCWAGSLWLFKDPCAAPNEGFCSAGVQTEAGVADLT 112 Query: 93 FHEDGRWMYTGGEDCTARIWDLRSRNLQC---QRIFQVNAPINCVCLHPNQAELIVGDQS 149 + + R + + +W+L ++ + ++ V + + + + G + Sbjct: 113 WVGE-RGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKD 171 Query: 150 GAIHIWDLKTDHNEQLIPEPEVSITSAHIDP-DASYMAAVNSTGNCYVWNLTGGIGDEVT 208 I +WDL +T P S + + +W+ Sbjct: 172 ICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQI 231 Query: 209 QLIPKTKIPAHTRYALQCRFSPDST-LLATCSADQTCKIWRTSNFSLMTELSIKSGNPGE 267 +P + P + + + T + T + S + ++ S Sbjct: 232 GCSAPGYLP------TSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQ---- 281 Query: 268 SSRGWMWGCAFSGDS-QYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFND 322 + G FS S ++ + S D + E+ R H+ V ++ Sbjct: 282 ----CVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRS-QAHRDFVRDATWSP 332 Score = 84.8 bits (208), Expect = 5e-17, Method: Composition-based stats. Identities = 41/240 (17%), Positives = 80/240 (33%), Gaps = 21/240 (8%) Query: 15 LATAGYDHTVRFWQAHSGICTRTVQ----HQDSQVNALEVTPDRSMIAAAGYQH-IRMYD 69 + A V W+ + D V+ + V + + I+++D Sbjct: 119 ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWD 178 Query: 70 LNSNNPNPIISYDGVNKNIASVGFHEDGRWMY-TGGEDCTARIWDLRSRNLQCQRIFQVN 128 L + SY + V ++ + ED +WD R Q Sbjct: 179 LA--QQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAP 236 Query: 129 API-NCVCLHPNQAELIV-GDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDP-DASYM 185 + + HP Q+E+ V GD++G + + D K+ +T P ++ Sbjct: 237 GYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFL 296 Query: 186 AAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSP-DSTLLATCSADQTC 244 A+++ + V + + L + AH + +SP + +LL T D Sbjct: 297 ASLSEDCSLAVLD---------SSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQV 347 Score = 71.7 bits (174), Expect = 4e-13, Method: Composition-based stats. Identities = 25/193 (12%), Positives = 62/193 (32%), Gaps = 7/193 (3%) Query: 7 TVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTP--DRSMIAAAGYQH 64 +V S + D ++ W + + + +QV + +P D ++ + Sbjct: 157 SVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNR 216 Query: 65 IRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRI 124 I ++D P I S+ +H ++ G D + + +++ C Sbjct: 217 ILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFG-DENGTVSLVDTKSTSCVLS 275 Query: 125 FQVNAP-INCVCLHPNQ-AELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDP-D 181 V++ + + P+ L + ++ + D + + A P + Sbjct: 276 SAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRS-QAHRDFVRDATWSPLN 334 Query: 182 ASYMAAVNSTGNC 194 S + V Sbjct: 335 HSLLTTVGWDHQV 347 Score = 52.8 bits (125), Expect = 2e-07, Method: Composition-based stats. Identities = 18/156 (11%), Positives = 49/156 (31%), Gaps = 6/156 (3%) Query: 3 TSPGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQV--NALEVTPDRSMIAAA 60 T + + D+ + W + +L P +S + Sbjct: 196 TCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVF 255 Query: 61 GYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDG-RWMYTGGEDCTARIWDLRSRNL 119 G ++ + +++ + + ++S ++ + + F ++ + EDC+ + L S Sbjct: 256 GDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAV--LDSSLS 313 Query: 120 QCQRIFQVNAPINCVCLHP-NQAELIVGDQSGAIHI 154 + R + P N + L + Sbjct: 314 ELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQVVH 349 Score = 45.9 bits (107), Expect = 2e-05, Method: Composition-based stats. Identities = 15/110 (13%), Positives = 30/110 (27%), Gaps = 2/110 (1%) Query: 1 MNTSPGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAA 60 + TS + + TV S C + V L +P A+ Sbjct: 239 LPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLAS 298 Query: 61 GYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTG-GEDCTA 109 + + L+S + + + + + + T G D Sbjct: 299 LSEDCSLAVLDS-SLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQV 347 >1PI6-A nrPDB Length = 615 Score = 86.4 bits (212), Expect = 1e-17, Method: Composition-based stats. Identities = 45/308 (14%), Positives = 96/308 (31%), Gaps = 32/308 (10%) Query: 38 VQHQ-DSQVNALEVTP-DRSMIAAAGYQ--HIRMYDL------NSNNPNPIISYDGVNKN 87 S V ++ +P S +G + + ++ NS N + + Sbjct: 59 FTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGP 118 Query: 88 IASVGFHEDGRWMYTGGED----CTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAEL 143 I+ + + +GR + GE WD + + + IN L ++ Sbjct: 119 ISDISWDFEGRRLCVVGEGRDNFGVFISWDSGNSLGEVS---GHSQRINACHLKQSRPMR 175 Query: 144 -IVGDQSGAIHIWDLKTDHNEQLIPEPE---VSITSAHIDPD-ASYMAAVNSTGNCYVWN 198 + G++ + + PD ++ V S ++ Sbjct: 176 SMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFD 235 Query: 199 LTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTEL 258 G + + + DS AT AD T ++W + + + Sbjct: 236 GKSGEFLK----YIEDDQEPVQGGIFALSWL-DSQKFATVGADATIRVWDVTTSKCVQKW 290 Query: 259 SIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCL 318 ++ G G + +G+ + I++ S D + + E+ + GH K + L Sbjct: 291 TLDKQQLGNQQVGVVA----TGNGR-IISLSLDGTLNFYELGHDEVLKTISGHNKGITAL 345 Query: 319 AFNDSVLG 326 N + G Sbjct: 346 TVNPLISG 353 Score = 68.6 bits (166), Expect = 3e-12, Method: Composition-based stats. Identities = 57/334 (17%), Positives = 113/334 (33%), Gaps = 56/334 (16%) Query: 2 NTSPGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAG 61 N G V + + + D T+ F++ +T+ + + AL V P +I+ + Sbjct: 299 NQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNP---LISGSY 355 Query: 62 YQHIRMYDLNS---NNPNPIISYDGVNK------------NIASVGFHEDGRW--MYTGG 104 I + +S ++ N I+S D + + HE G + + Sbjct: 356 DGRIMEWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASAN 415 Query: 105 EDCTARIWD-------LRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSG-AIHIWD 156 D + L+S + ++N+P + V L N + VG + G I ++ Sbjct: 416 NDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQN--YVAVGLEEGNTIQVFK 473 Query: 157 LKTDHNEQLIPEPEVSITS-AHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTK 215 L + P + S I P +Y+AA + G +++L Sbjct: 474 LSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAF---- 529 Query: 216 IPAHTRYALQCRFSP----------DSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNP 265 T + P + L+AT S D I+ + +K Sbjct: 530 ---RTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSV-------KRPMKIIKA 579 Query: 266 GESSRGWMWGCAFSGDSQYIVTASSDNLARLWCV 299 + + + + S +V++ +D + W V Sbjct: 580 LNAHKDGVNNLLWETPS-TLVSSGADACIKRWNV 612 Score = 68.6 bits (166), Expect = 3e-12, Method: Composition-based stats. Identities = 49/352 (13%), Positives = 107/352 (30%), Gaps = 64/352 (18%) Query: 11 DPVILATAGYDHTVRFWQAHSGICTR--TVQHQD--SQVNALEVTPDRSMIAAAGYQHIR 66 D AT G D T+R W + C + T+ Q +Q + T + +I+ + + Sbjct: 263 DSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLN 322 Query: 67 MYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQ 126 Y+L + + + G NK I ++ + + +G D W S + + Sbjct: 323 FYEL--GHDEVLKTISGHNKGITALTVNP----LISGSYDGRIMEWSSSSMHQDHSNLIV 376 Query: 127 V-----NAPINCVCLHP-------------NQAELIVGDQSGAIHIWDLKTDHNEQLIPE 168 + + +Q ++ + G + L D + ++ Sbjct: 377 SLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFTAV--LTNDDDLLILQS 434 Query: 169 PEVSIT--------SAHIDPDASYMAAVNSTGN-CYVWNLTGGIGDEVTQLIPKTKIPAH 219 I + + +Y+A GN V+ L+ + + K Sbjct: 435 FTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAK---- 490 Query: 220 TRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFS 279 SP T +A ++ + + T + + ++ Sbjct: 491 ---PSYISISPSETYIAAGDVMGKILLYDLQSREVKT-------SRWAFRTSKINAISWK 540 Query: 280 G----------DSQYIVTASSDNLARLWCVET-GEIKREYGGHQKAVVCLAF 320 + + T S D ++ V+ +I + H+ V L + Sbjct: 541 PAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLW 592 >4G56-B nrPDB Length = 357 Score = 86.4 bits (212), Expect = 1e-17, Method: Composition-based stats. Identities = 30/242 (12%), Positives = 75/242 (30%), Gaps = 20/242 (8%) Query: 86 KNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIF---QVNAPINCVCLHPNQAE 142 + V + + + + +W++ + F + + + + + + + Sbjct: 95 AGVTDVAWVSEKGILV-ASDSGAVELWEILEKESLLVNKFAKYEHDDIVKTLSVFSDGTQ 153 Query: 143 LIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDP-DASYMAAVNSTGNCYVWNLTG 201 + G + ++ +WDL + + P + + G +W+ Sbjct: 154 AVSGGKDFSVKVWDLSQKAVLKSYNAHSSEVNCVAACPGKDTIFLSCGEDGRILLWDTRK 213 Query: 202 GIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIK 261 IP + P+ C + T N SL+ + Sbjct: 214 PKPATRIDFCASDTIP------TSVTWHPEKDDTFACGDE-------TGNVSLVNIKNPD 260 Query: 262 SGNPGESSRGWMWGCAFSG-DSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAF 320 S + G A+S S ++ + S D + + E+ R+ H+ V +A+ Sbjct: 261 SAQTSAVHSQNITGLAYSYHSSPFLASISEDCTVAVLDADFSEVFRDLS-HRDFVTGVAW 319 Query: 321 ND 322 + Sbjct: 320 SP 321 Score = 85.2 bits (209), Expect = 3e-17, Method: Composition-based stats. Identities = 40/240 (16%), Positives = 79/240 (32%), Gaps = 21/240 (8%) Query: 15 LATAGYDHTVRFWQAHSGICTRTVQ----HQDSQVNALEVTPDRSMIAAAGYQ-HIRMYD 69 + A V W+ + D V L V D + + G ++++D Sbjct: 108 ILVASDSGAVELWEILEKESLLVNKFAKYEHDDIVKTLSVFSDGTQAVSGGKDFSVKVWD 167 Query: 70 LNSNNPNPIISYDGVNKNIASVGFHEDGRWMY-TGGEDCTARIWDLRSRNLQCQRIFQVN 128 L + + SY+ + + V ++ + GED +WD R + F + Sbjct: 168 L--SQKAVLKSYNAHSSEVNCVAACPGKDTIFLSCGEDGRILLWDTRKPKPATRIDFCAS 225 Query: 129 API-NCVCLHPN-QAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHID-PDASYM 185 I V HP GD++G + + ++K + Q +IT + ++ Sbjct: 226 DTIPTSVTWHPEKDDTFACGDETGNVSLVNIKNPDSAQTSAVHSQNITGLAYSYHSSPFL 285 Query: 186 AAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSP-DSTLLATCSADQTC 244 A+++ V + +H + +SP D + T D Sbjct: 286 ASISEDCTVAVLDADFSEVFRDL---------SHRDFVTGVAWSPLDHSKFTTVGWDHKV 336 Score = 71.3 bits (173), Expect = 6e-13, Method: Composition-based stats. Identities = 32/193 (16%), Positives = 63/193 (32%), Gaps = 7/193 (3%) Query: 7 TVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTP--DRSMIAAAGYQH 64 +V SD + G D +V+ W ++ S+VN + P D ++ Sbjct: 146 SVFSDGTQAVSGGKDFSVKVWDLSQKAVLKSYNAHSSEVNCVAACPGKDTIFLSCGEDGR 205 Query: 65 IRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRI 124 I ++D P I + + SV +H + + G D T + + +N + Sbjct: 206 ILLWDTRKPKPATRIDFCASDTIPTSVTWHPEKDDTFACG-DETGNVSLVNIKNPDSAQT 264 Query: 125 FQVNAP-INCVCLHP-NQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDP-D 181 V++ I + + L + + + D + + +T P D Sbjct: 265 SAVHSQNITGLAYSYHSSPFLASISEDCTVAVLDADFSEVFRDL-SHRDFVTGVAWSPLD 323 Query: 182 ASYMAAVNSTGNC 194 S V Sbjct: 324 HSKFTTVGWDHKV 336 Score = 60.2 bits (144), Expect = 1e-09, Method: Composition-based stats. Identities = 21/146 (14%), Positives = 49/146 (33%), Gaps = 6/146 (4%) Query: 13 VILATAGYDHTVRFWQAHSGICTRTVQ--HQDSQVNALEVTPDRSMIAAAGYQHIRMYDL 70 I + G D + W + D+ ++ P++ A G + + + Sbjct: 195 TIFLSCGEDGRILLWDTRKPKPATRIDFCASDTIPTSVTWHPEKDDTFACGDETGNVSLV 254 Query: 71 NSNNPNPIISYDGVNKNIASVGFH-EDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNA 129 N NP+ + ++NI + + ++ + EDCT + L + + R Sbjct: 255 NIKNPDSAQTSAVHSQNITGLAYSYHSSPFLASISEDCTVAV--LDADFSEVFRDLSHRD 312 Query: 130 PINCVCLHP-NQAELIVGDQSGAIHI 154 + V P + ++ + Sbjct: 313 FVTGVAWSPLDHSKFTTVGWDHKVLH 338 >3ACP-A nrPDB Length = 417 Score = 86.0 bits (211), Expect = 2e-17, Method: Composition-based stats. Identities = 42/329 (12%), Positives = 97/329 (29%), Gaps = 39/329 (11%) Query: 3 TSPGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGY 62 T+ T + ++ ++ + Q S++ L+ P + ++ Sbjct: 97 TAVDTAKLQMRRFILGTTEGDIKVLDSNFNLQREIDQAHVSEITKLKFFPSGEALISSSQ 156 Query: 63 Q-HIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQC 121 ++++ + + + G + + + GR + + D T R+W+ + Sbjct: 157 DMQLKIWSVKDGSNPR--TLIGHRATVTDIAIIDRGRNVLSASLDGTIRLWECGTGTTIH 214 Query: 122 QRIFQVNAP--INCVC---------------------LHPNQAELIVGDQSGAIHIWDL- 157 + N +N + +I G SG I + ++ Sbjct: 215 TFNRKENPHDGVNSIALFVGTDRQLHEISTSKKNNLEFGTYGKYVIAGHVSGVITVHNVF 274 Query: 158 KTDHNEQLIPEPEVSITSAHID-PDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKI 216 + QL + S S +D +A+Y+ A G W+L LI + Sbjct: 275 SKEQTIQLPSKFTCSCNSLTVDGNNANYIYAGYENGMLAQWDLRSPECPVGEFLINEGT- 333 Query: 217 PAHTRYALQCRFSPDSTLLATCSADQTCK---IWRTSNFSLMTELSIKSGNPGESSRGWM 273 F+ L + D + K I + E + Sbjct: 334 -----PINNVYFAA-GALFVSSGFDTSIKLDIISDPESERPAIEFETPTFLVSNDDEVSQ 387 Query: 274 WGCAFSGDSQ-YIVTASSDNLARLWCVET 301 + +S ++ +N L+ + Sbjct: 388 FCYVSDDESNGEVLEVGKNNFCALYNLSN 416 Score = 77.1 bits (188), Expect = 1e-14, Method: Composition-based stats. Identities = 37/301 (12%), Positives = 83/301 (27%), Gaps = 30/301 (9%) Query: 15 LATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLNSNN 74 L A D + ++ ++ D R I I++ L+SN Sbjct: 68 LYKARLDGHDFLFNTIIRDGSKMLKRADYTAVDTAKLQMRRFILGTTEGDIKV--LDSNF 125 Query: 75 PNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCV 134 I + F G + + +D +IW ++ + + + A + + Sbjct: 126 NLQREIDQAHVSEITKLKFFPSGEALISSSQDMQLKIWSVKDGSNP-RTLIGHRATVTDI 184 Query: 135 CLHPNQAELIVGDQSGAIHIWDLKTDHNEQLI---PEPEVSITSAH--IDPDASYM-AAV 188 + ++ G I +W+ T P + S + D + Sbjct: 185 AIIDRGRNVLSASLDGTIRLWECGTGTTIHTFNRKENPHDGVNSIALFVGTDRQLHEIST 244 Query: 189 NSTGNCY--------VWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSP----DSTLLA 236 + N + G+ + I +++ C ++ + Sbjct: 245 SKKNNLEFGTYGKYVIAGHVSGVITVHNVFSKEQTIQLPSKFTCSCNSLTVDGNNANYIY 304 Query: 237 TCSADQTCKIWRTSNFSL-MTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLAR 295 + W + + E I G P + F+ V++ D + Sbjct: 305 AGYENGMLAQWDLRSPECPVGEFLINEGTP-------INNVYFAA-GALFVSSGFDTSIK 356 Query: 296 L 296 L Sbjct: 357 L 357 Score = 75.2 bits (183), Expect = 3e-14, Method: Composition-based stats. Identities = 32/226 (14%), Positives = 61/226 (26%), Gaps = 29/226 (12%) Query: 98 RWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDL 157 R G + ++ D + NLQ + + I + P+ LI Q + IW + Sbjct: 107 RRFILGTTEGDIKVLD-SNFNLQREIDQAHVSEITKLKFFPSGEALISSSQDMQLKIWSV 165 Query: 158 KTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQ-------- 209 K N + + ++T I + + + G +W G Sbjct: 166 KDGSNPRTLIGHRATVTDIAIIDRGRNVLSASLDGTIRLWECGTGTTIHTFNRKENPHDG 225 Query: 210 -----LIPKTKIPAH---TRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIK 261 L T H T F + + + +L Sbjct: 226 VNSIALFVGTDRQLHEISTSKKNNLEFGTYGKYVIAGHVSGVITVHNVFSKEQTIQLP-- 283 Query: 262 SGNPGESSRGWMWGCAFSGDS---QYIVTASSDNLARLWCVETGEI 304 S+ + + D YI + + W + + E Sbjct: 284 -------SKFTCSCNSLTVDGNNANYIYAGYENGMLAQWDLRSPEC 322 Score = 64.4 bits (155), Expect = 7e-11, Method: Composition-based stats. Identities = 28/141 (19%), Positives = 44/141 (31%), Gaps = 19/141 (13%) Query: 183 SYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQ 242 + G+ V + + E+ Q AH + +F P L + S D Sbjct: 107 RRFILGTTEGDIKVLDSNFNLQREIDQ--------AHVSEITKLKFFPSGEALISSSQDM 158 Query: 243 TCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETG 302 KIW + S L R + A + +++AS D RLW TG Sbjct: 159 QLKIWSVKDGSNPRTL--------IGHRATVTDIAIIDRGRNVLSASLDGTIRLWECGTG 210 Query: 303 EIKREY---GGHQKAVVCLAF 320 + V +A Sbjct: 211 TTIHTFNRKENPHDGVNSIAL 231 Score = 44.0 bits (102), Expect = 9e-05, Method: Composition-based stats. Identities = 25/144 (17%), Positives = 56/144 (38%), Gaps = 17/144 (11%) Query: 177 HIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLA 236 + S++ G+ +++N I + ++++ + A LQ R Sbjct: 60 TFEKVGSHLYKARLDGHDFLFNT---IIRDGSKMLKRADYTAVDTAKLQMR------RFI 110 Query: 237 TCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARL 296 + + K+ SNF+L E+ ++ + F + ++++S D ++ Sbjct: 111 LGTTEGDIKVLD-SNFNLQREI-------DQAHVSEITKLKFFPSGEALISSSQDMQLKI 162 Query: 297 WCVETGEIKREYGGHQKAVVCLAF 320 W V+ G R GH+ V +A Sbjct: 163 WSVKDGSNPRTLIGHRATVTDIAI 186 >4E5Z-B nrPDB Length = 436 Score = 85.6 bits (210), Expect = 3e-17, Method: Composition-based stats. Identities = 42/304 (13%), Positives = 91/304 (29%), Gaps = 14/304 (4%) Query: 29 AHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQ--HIRMYDLNSNNPNPIISYDGVNK 86 S + D + +L P A G + I +++ + I G Sbjct: 106 LDSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGG 165 Query: 87 NIASVGFHE-DGRWMYTGGEDCTARIWDLRSRNLQCQRIF-QVNAPINCVCLHPNQAELI 144 +I + F+ + Y + T R+ D + L+ +N + + + ++ Sbjct: 166 SITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVV 225 Query: 145 VGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDAS-YMAAVNSTGNCYVWNLTGGI 203 GD G + + ++ + + +T ++P ++A + +W+L Sbjct: 226 TGDNVGNVILLNMD-GKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVR 284 Query: 204 GDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSG 263 G H FSPD L T +++ S + L Sbjct: 285 GKASFLYSLP-----HRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPH 339 Query: 264 NPGESSRGWMWGCAFSGDSQYIVTA-SSDNLARLWCVETGEIKREYGGHQKAVVCLAFND 322 + A+ IV D + + G+ ++C ++ Sbjct: 340 RHFQHLTP--IKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDP 397 Query: 323 SVLG 326 G Sbjct: 398 ESSG 401 Score = 75.2 bits (183), Expect = 4e-14, Method: Composition-based stats. Identities = 46/306 (15%), Positives = 88/306 (28%), Gaps = 61/306 (19%) Query: 3 TSPGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQH--QDSQVNALEVTP-------- 52 TS + P +A + W ++ + L+ P Sbjct: 123 TSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYA 182 Query: 53 ------------DRSMI-AAAGYQHIRMY----DLNSN------------------NPNP 77 +++ A I ++ D++++ + Sbjct: 183 SSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDGKE 242 Query: 78 IISYDGVNKNIASVGFHEDGRW-MYTGGEDCTARIWDLRSRNLQCQRIFQ--VNAPINCV 134 + + K + V + W + T D T +IWDLR + ++ P+N Sbjct: 243 LWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAA 302 Query: 135 CLHPNQAELIVGDQSGAIHIWDLKT-DHNEQLIPEPEVSIT-----SAHIDPDASYMAAV 188 C P+ A L+ DQ I ++ D LIP P A P + + Sbjct: 303 CFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVG 362 Query: 189 -NSTGNCYVWNLTGGIGDEVT-----QLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQ 242 N +V +++ + P + + F+P LA+ Sbjct: 363 RYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDTLASAMGYH 422 Query: 243 TCKIWR 248 IW Sbjct: 423 IL-IWS 427 >3F3P-A nrPDB Length = 351 Score = 84.4 bits (207), Expect = 6e-17, Method: Composition-based stats. Identities = 43/330 (13%), Positives = 98/330 (29%), Gaps = 77/330 (23%) Query: 40 HQDSQVNALEVT-PDRSMIAAAGYQHIRMY--DLNSNNPNPIISYDGVNKNIASVGFHED 96 D V+ + R + + QHI+++ D +++N S+ + +I ++ + Sbjct: 9 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 68 Query: 97 --GRWMYTGGEDCTARIWDLRSRNLQCQ--------RIFQVNAPINCVCLHPN--QAELI 144 GR + + D T ++W+ +C + + V P +L Sbjct: 69 EYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLA 128 Query: 145 VGDQSGAIHIWDL--KTDHNEQLIPEP-------------EVSITSAHIDPDASYMAAVN 189 G + ++D +D + S + AV+ Sbjct: 129 CLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVS 188 Query: 190 STGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPD-STL---LATCSADQTCK 245 + ++ + +L K+P H ++P +AT D + Sbjct: 189 ALEQAIIYQ-----RGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIR 243 Query: 246 IWRT--------------------------------------SNFSLMTELSIKSGNPGE 267 I++ L + L ++ + + Sbjct: 244 IFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHD 303 Query: 268 SSRGWMWGCAFSGDSQYIVTASSDNLARLW 297 G +W +++ + +A D RLW Sbjct: 304 DHNGEVWSVSWNLTGTILSSAGDDGKVRLW 333 Score = 65.9 bits (159), Expect = 2e-11, Method: Composition-based stats. Identities = 45/322 (13%), Positives = 103/322 (31%), Gaps = 77/322 (23%) Query: 15 LATAGYDHTVRFW----QAHSGICTRTVQHQDSQVNALEV-TPDRSMIAAAG--YQHIRM 67 +AT D ++ + + + + + DS + A++ +P+ I A+ + +++ Sbjct: 26 VATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEYGRIIASASYDKTVKL 85 Query: 68 YDLNSNNPNP-------IISYDGVNKNIASVGFHED--GRWMYTGGEDCTARIWD----- 113 ++ + + + + + ++ SV F G + G D R++D Sbjct: 86 WEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPS 145 Query: 114 -LRSRNLQCQRIFQVNAPIN------CVCLHPN---QAELIVGDQSGAIHIWDLKTDHNE 163 LRS L + P N C+ P+ +L V AI I+ D Sbjct: 146 DLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQAI-IYQRGKDGKL 204 Query: 164 QL---IPEPEVSITSAHIDPDA----SYMAAVNSTGNCYVWNLTGGIG------------ 204 + +P + I S P +A G ++ +T + Sbjct: 205 HVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSN 264 Query: 205 --------------------------DEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATC 238 Q+ ++ H ++ T+L++ Sbjct: 265 MFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSA 324 Query: 239 SADQTCKIWRTSNFSLMTELSI 260 D ++W+ + + +S+ Sbjct: 325 GDDGKVRLWKATYSNEFKCMSV 346 Score = 56.3 bits (134), Expect = 2e-08, Method: Composition-based stats. Identities = 26/218 (11%), Positives = 70/218 (32%), Gaps = 19/218 (8%) Query: 126 QVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLI----PEPEVSITSAHI-DP 180 + ++ V + I ++ L D + + + SI + P Sbjct: 9 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 68 Query: 181 D-ASYMAAVNSTGNCYVWNLTGGIGDEV-TQLIPKTKIPAHTRYALQCRFSPD--STLLA 236 + +A+ + +W + + + +F+P LA Sbjct: 69 EYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLA 128 Query: 237 TCSADQTCKIWR------TSNFSLMTELSIKSGNP-GESSRGWMWGCAFSGDSQYIVTAS 289 D +++ +++L +E+ + S P + S S + S Sbjct: 129 CLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVS 188 Query: 290 SDNLARLWCV-ETGEIK--REYGGHQKAVVCLAFNDSV 324 + A ++ + G++ + GH+ + +++ S+ Sbjct: 189 ALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSI 226 Score = 31.3 bits (69), Expect = 0.62, Method: Composition-based stats. Identities = 8/71 (11%), Positives = 22/71 (30%), Gaps = 4/71 (5%) Query: 260 IKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLW----CVETGEIKREYGGHQKAV 315 + + +++ T SSD +++ E+ + H ++ Sbjct: 1 PHMQPFDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSI 60 Query: 316 VCLAFNDSVLG 326 V + + G Sbjct: 61 VAIDWASPEYG 71 >3W15-A nrPDB Length = 368 Score = 83.7 bits (205), Expect = 1e-16, Method: Composition-based stats. Identities = 44/292 (15%), Positives = 94/292 (32%), Gaps = 47/292 (16%) Query: 53 DRSMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRW-MYTGGEDCTARI 111 + ++ A G +R++D + PI + + + S ++ R + D + +I Sbjct: 75 ENQVLVAQGDGTLRLFD-TTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKI 133 Query: 112 WD-LRSRNLQCQR-------------------------IFQVNAPINCVCLHP-NQAELI 144 W LR ++L I + + P +Q ++ Sbjct: 134 WSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVL 193 Query: 145 VGDQSGAIHIWDLK--TDHNEQLIPEPEV-SITSAHIDPDASYM-AAVNSTGNCYVWN-- 198 + ++D++ + N+ + + Y+ A +W+ Sbjct: 194 SCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIR 253 Query: 199 -LTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPD-STLLATCSADQTCKIW-RTSNFSLM 255 L G AH + +SP S +L + S D TC+IW SN Sbjct: 254 MLNKNPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAK 313 Query: 256 TELSIKSGNPGES-------SRGWMWGCAFSGDSQ--YIVTASSDNLARLWC 298 S + + +++G +S + Y+ + + D +W Sbjct: 314 ETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 365 Score = 75.2 bits (183), Expect = 4e-14, Method: Composition-based stats. Identities = 39/263 (14%), Positives = 87/263 (33%), Gaps = 48/263 (18%) Query: 15 LATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLNSNN 74 ++ +D +++ W T+ TP I +M D + Sbjct: 122 FLSSSWDGSIKIWSPLRKQSLMTL------------TPRPLEI-------TKMVDPLNAI 162 Query: 75 PNPIISYDGVNKNIASV---GFHE-DGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAP 130 S+ G++KN V F D + + + A ++D+R + + Q F V++ Sbjct: 163 ILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSG 222 Query: 131 INCVCLHPN---QAELIVGDQSGAIHIWDLK-----------TDHNEQLIPEPEVSITSA 176 + + N + G AI IWD++ + ++ ++I Sbjct: 223 LEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNPGQLHNSSCINEIPNAHGLAIRKV 282 Query: 177 HIDP-DASYMAAVNSTGNCYVW-NLTGGIGDEVTQLIPKT-------KIPAHTRYALQCR 227 P ++ + + + C +W +L+ E + H+ + Sbjct: 283 TWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGAD 342 Query: 228 FSPDST--LLATCSADQTCKIWR 248 +S +A+ + D +W Sbjct: 343 WSLWGKPGYVASTAWDGNLFVWN 365 Score = 69.4 bits (168), Expect = 2e-12, Method: Composition-based stats. Identities = 41/297 (13%), Positives = 93/297 (31%), Gaps = 51/297 (17%) Query: 46 NALEVTP--DRSMIAAAGYQ-------HIRMYDLN-SNNPNPIISYDGVNKNIASVGFHE 95 ++ +P D + AAG + + +++ S + S+ + + + ++E Sbjct: 14 YGVQYSPFFDNRLAVAAGSNFGLVGNGKLFILEIDRSGRIVEVNSFLTQDC-LFDLAWNE 72 Query: 96 DG-RWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLH-PNQAELIVGDQSGAIH 153 + D T R++D + + + + N+ + G+I Sbjct: 73 SHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIK 132 Query: 154 IWDLKTDHNEQLIPEPEVSIT---------------------------SAHIDP-DASYM 185 IW + + + IT A P D + + Sbjct: 133 IWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLV 192 Query: 186 AAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDS-TLLATCSADQTC 244 + + ++++ G + + + A L C F+ ++AT D Sbjct: 193 LSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEA-----LTCDFNKYRPYVVATGGVDNAI 247 Query: 245 KIWRTSNFSLMTELSIKSGNPGE---SSRGWMWGCAFSG-DSQYIVTASSDNLARLW 297 +IW + S E + + +S S +++AS D R+W Sbjct: 248 RIWDIRMLNKNPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIW 304 Score = 46.7 bits (109), Expect = 1e-05, Method: Composition-based stats. Identities = 18/131 (13%), Positives = 47/131 (35%), Gaps = 29/131 (22%) Query: 12 PVILATAGYDHTVRFWQ----------AHSGICTRTVQH-QDSQVNALEVTP--DRSMIA 58 P ++AT G D+ +R W H+ C + + + + +P +++ Sbjct: 235 PYVVATGGVDNAIRIWDIRMLNKNPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMS 294 Query: 59 AAGYQHIRMYDLNSNNPNP--------------IISYDGVNKNIASVGFHEDGR--WMYT 102 A+ R++ SN+ I ++ ++ + + G+ ++ + Sbjct: 295 ASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVAS 354 Query: 103 GGEDCTARIWD 113 D +W+ Sbjct: 355 TAWDGNLFVWN 365 Score = 46.3 bits (108), Expect = 2e-05, Method: Composition-based stats. Identities = 26/168 (15%), Positives = 54/168 (32%), Gaps = 32/168 (19%) Query: 179 DPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSP-DSTLLAT 237 + + A G +++ T + P H R C ++ + + Sbjct: 73 SHENQVLVAQG-DGTLRLFDTT-------FKEFPIAIFKEHEREVFSCNWNLVNRQNFLS 124 Query: 238 CSADQTCKIWRTSNFSLMTELSI-------------------KSGNPGESSRGWMWGCAF 278 S D + KIW + L+ KS +R ++ F Sbjct: 125 SSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQF 184 Query: 279 SG-DSQYIVTASSDNLARLWCVE--TGEIKREYGGHQK-AVVCLAFND 322 S D +++ S ++ A L+ + +G+ + + H + FN Sbjct: 185 SPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNK 232 >5WLC-SG nrPDB Length = 573 Score = 83.7 bits (205), Expect = 1e-16, Method: Composition-based stats. Identities = 37/312 (11%), Positives = 87/312 (27%), Gaps = 46/312 (14%) Query: 36 RTVQHQDSQVNALEVTPDRSMIAAAG-YQHIRMYDLNSNNPNPIISYDGVNKNIASVGFH 94 T + ++ + +PD + G + + ++ S +P +I + S+ F Sbjct: 230 NTTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRRGEVLSLAFR 289 Query: 95 EDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHI 154 ++ +Y D R + + + Q + ++ + + + + + VG + + Sbjct: 290 KNSDQLYASCADFKIRTYSINQFS-QLEILYGHHDIVEDISALAMERCVTVGARDRTAML 348 Query: 155 WDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKT 214 W + D + + A G + E + Sbjct: 349 WKI-PDETRLTFRGGDEPQKLLRRWMKEN--AKEGEDGEVKYPD-----ESEAPLFFCEG 400 Query: 215 KIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRG--- 271 I + D T S + +W + + I G E S Sbjct: 401 SIDVVSMV--------DDFHFITGSDNGNICLWSLAKKKPIFTERIAHGILPEPSFNDIS 452 Query: 272 ---------------------WMWGCAFSGDSQYIVTASSDNLARLW----CVETGEIKR 306 W+ S ++ S ++W + + E+ Sbjct: 453 GETDEELRKRQLQGKKLLQPFWITSLYAIPYSNVFISGSWSGSLKVWKISDNLRSFELLG 512 Query: 307 EYGGHQKAVVCL 318 E G + V + Sbjct: 513 ELSGAKGVVTKI 524 Score = 79.4 bits (194), Expect = 2e-15, Method: Composition-based stats. Identities = 47/287 (16%), Positives = 88/287 (30%), Gaps = 42/287 (14%) Query: 8 VGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQD--SQVNALEVTPDRSMI-AAAGYQH 64 D + T G D + W S + + +D +V +L + + A+ Sbjct: 244 ASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRRGEVLSLAFRKNSDQLYASCADFK 303 Query: 65 IRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRI 124 IR Y + N + + G + + + R + G D TA +W + R Sbjct: 304 IRTYSI--NQFSQLEILYGHHDIVEDISALAMERCVTVGARDRTAMLWKIPDETRLTFR- 360 Query: 125 FQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASY 184 + P L E + G + D E + + S D + Sbjct: 361 -GGDEP--QKLLRRWMKENAKEGEDGEVKYPD--ESEAPLFFCEGSIDVVSMV---DDFH 412 Query: 185 MAAVNSTGNCYVW------------------------NLTGGIGDEVTQLIPKTKIPAHT 220 + GN +W +++G +E+ + + K Sbjct: 413 FITGSDNGNICLWSLAKKKPIFTERIAHGILPEPSFNDISGETDEELRKRQLQGKKLLQP 472 Query: 221 RYALQCRFSPDSTLLATCSADQTCKIW----RTSNFSLMTELSIKSG 263 + P S + + S + K+W +F L+ ELS G Sbjct: 473 FWITSLYAIPYSNVFISGSWSGSLKVWKISDNLRSFELLGELSGAKG 519 Score = 64.8 bits (156), Expect = 5e-11, Method: Composition-based stats. Identities = 25/170 (14%), Positives = 52/170 (30%), Gaps = 21/170 (12%) Query: 165 LIPEPEVSITSAHIDPDASYMA-AVNSTGNCYVWNLTGGIGDE--------------VTQ 209 ++ + +S A V+ +++T ++ Sbjct: 166 VLNKYTFEESSNGDKNKGRLFAYTVSKDLQLTKYDITDFSKRPKKLKYAKGGAKYIPTSK 225 Query: 210 LIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESS 269 + H L SPD + T D+ +W T + S + + P + Sbjct: 226 HEYENTTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVI------PTKDR 279 Query: 270 RGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLA 319 RG + AF +S + + +D R + + GH V ++ Sbjct: 280 RGEVLSLAFRKNSDQLYASCADFKIRTYSINQFSQLEILYGHHDIVEDIS 329 Score = 43.6 bits (101), Expect = 1e-04, Method: Composition-based stats. Identities = 15/68 (22%), Positives = 25/68 (36%), Gaps = 2/68 (2%) Query: 255 MTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGG--HQ 312 + + N E + A S D +Y+VT D +W E+ + + Sbjct: 221 IPTSKHEYENTTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRR 280 Query: 313 KAVVCLAF 320 V+ LAF Sbjct: 281 GEVLSLAF 288 >2PM9-A nrPDB Length = 416 Score = 83.3 bits (204), Expect = 1e-16, Method: Composition-based stats. Identities = 43/283 (15%), Positives = 93/283 (32%), Gaps = 29/283 (10%) Query: 60 AGYQHIRMYDL-NSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRN 118 + + ++ L +++ PI S +K + + + + + ++ + ++ N Sbjct: 42 STDSSLELWSLLAADSEKPIASLQVDSKF-NDLDWSHNNKIIAGALDNGSLELYSTNEAN 100 Query: 119 LQC---QRIFQVNAPINCVCLHP-NQAELIVGDQSGAIHIWDLKT-----DHNEQLIPEP 169 R ++ + V + L G +G I IWD+ + L P Sbjct: 101 NAINSMARFSNHSSSVKTVKFNAKQDNVLASGGNNGEIFIWDMNKCTESPSNYTPLTPGQ 160 Query: 170 E----VSITSAHIDPD-ASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYAL 224 + S + A A+ S+ +W+L EV L + + Sbjct: 161 SMSSVDEVISLAWNQSLAHVFASAGSSNFASIWDLKA--KKEVIHLSYTSPNSGIKQQLS 218 Query: 225 QCRFSP-DSTLLATCSA---DQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAF-S 279 + P +ST +AT + D + IW N + + + + + Sbjct: 219 VVEWHPKNSTRVATATGSDNDPSILIWDLRN------ANTPLQTLNQGHQKGILSLDWCH 272 Query: 280 GDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFND 322 D ++++ DN LW E+ E ++ F Sbjct: 273 QDEHLLLSSGRDNTVLLWNPESAEQLSQFPARGNWCFKTKFAP 315 Score = 70.9 bits (172), Expect = 7e-13, Method: Composition-based stats. Identities = 38/242 (15%), Positives = 74/242 (30%), Gaps = 22/242 (9%) Query: 8 VGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQ---------VNALEVTPDRS--M 56 +LA+ G + + W + + + + V +L + Sbjct: 122 NAKQDNVLASGGNNGEIFIWDMNKCTESPSNYTPLTPGQSMSSVDEVISLAWNQSLAHVF 181 Query: 57 IAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIAS----VGFHEDGRWMY---TGGE-DCT 108 +A ++DL + +SY N I V +H TG + D + Sbjct: 182 ASAGSSNFASIWDLKAKKEVIHLSYTSPNSGIKQQLSVVEWHPKNSTRVATATGSDNDPS 241 Query: 109 ARIWDLRSRNLQCQRIFQVNAP-INCVCL-HPNQAELIVGDQSGAIHIWDLKTDHNEQLI 166 IWDLR+ N Q + Q + I + H ++ L+ + + +W+ ++ Sbjct: 242 ILIWDLRNANTPLQTLNQGHQKGILSLDWCHQDEHLLLSSGRDNTVLLWNPESAEQLSQF 301 Query: 167 PEPEVSITSAHIDPDAS-YMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQ 225 P P+A A + V L Q + + T + Sbjct: 302 PARGNWCFKTKFAPEAPDLFACASFDNKIEVQTLQNLTNTLDEQETETKQQESETDFWNN 361 Query: 226 CR 227 Sbjct: 362 VS 363 >4J0X-A nrPDB Length = 451 Score = 82.5 bits (202), Expect = 2e-16, Method: Composition-based stats. Identities = 37/312 (11%), Positives = 88/312 (28%), Gaps = 46/312 (14%) Query: 36 RTVQHQDSQVNALEVTPDRSMIAAAG-YQHIRMYDLNSNNPNPIISYDGVNKNIASVGFH 94 T + ++ + +PD + G + + ++ S +P +I + S+ F Sbjct: 108 NTTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRRGEVLSLAFR 167 Query: 95 EDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHI 154 ++ +Y D R + + ++ Q + ++ + + + + + VG + + Sbjct: 168 KNSDQLYASCADFKIRTYSI-NQFSQLEILYGHHDIVEDISALAMERCVTVGARDRTAML 226 Query: 155 WDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKT 214 W + D + + A G + E + Sbjct: 227 WKI-PDETRLTFRGGDEPQKLLRRWMKEN--AKEGEDGEVKYPD-----ESEAPLFFCEG 278 Query: 215 KIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRG--- 271 I + D T S + +W + + I G E S Sbjct: 279 SIDVVSMV--------DDFHFITGSDNGNICLWSLAKKKPIFTERIAHGILPEPSFNDIS 330 Query: 272 ---------------------WMWGCAFSGDSQYIVTASSDNLARLW----CVETGEIKR 306 W+ S ++ S ++W + + E+ Sbjct: 331 GETDEELRKRQLQGKKLLQPFWITSLYAIPYSNVFISGSWSGSLKVWKISDNLRSFELLG 390 Query: 307 EYGGHQKAVVCL 318 E G + V + Sbjct: 391 ELSGAKGVVTKI 402 Score = 78.7 bits (192), Expect = 3e-15, Method: Composition-based stats. Identities = 47/287 (16%), Positives = 88/287 (30%), Gaps = 42/287 (14%) Query: 8 VGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQD--SQVNALEVTPDRSMI-AAAGYQH 64 D + T G D + W S + + +D +V +L + + A+ Sbjct: 122 ASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRRGEVLSLAFRKNSDQLYASCADFK 181 Query: 65 IRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRI 124 IR Y + N + + G + + + R + G D TA +W + R Sbjct: 182 IRTYSI--NQFSQLEILYGHHDIVEDISALAMERCVTVGARDRTAMLWKIPDETRLTFR- 238 Query: 125 FQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASY 184 + P L E + G + D E + + S D + Sbjct: 239 -GGDEP--QKLLRRWMKENAKEGEDGEVKYPD--ESEAPLFFCEGSIDVVSMV---DDFH 290 Query: 185 MAAVNSTGNCYVW------------------------NLTGGIGDEVTQLIPKTKIPAHT 220 + GN +W +++G +E+ + + K Sbjct: 291 FITGSDNGNICLWSLAKKKPIFTERIAHGILPEPSFNDISGETDEELRKRQLQGKKLLQP 350 Query: 221 RYALQCRFSPDSTLLATCSADQTCKIW----RTSNFSLMTELSIKSG 263 + P S + + S + K+W +F L+ ELS G Sbjct: 351 FWITSLYAIPYSNVFISGSWSGSLKVWKISDNLRSFELLGELSGAKG 397 Score = 64.4 bits (155), Expect = 6e-11, Method: Composition-based stats. Identities = 25/170 (14%), Positives = 52/170 (30%), Gaps = 21/170 (12%) Query: 165 LIPEPEVSITSAHIDPDASYMA-AVNSTGNCYVWNLTGGIGDE--------------VTQ 209 ++ + +S A V+ +++T ++ Sbjct: 44 VLNKYTFEESSNGDKNKGRLFAYTVSKDLQLTKYDITDFSKRPKKLKYAKGGAKYIPTSK 103 Query: 210 LIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESS 269 + H L SPD + T D+ +W T + S + + P + Sbjct: 104 HEYENTTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVI------PTKDR 157 Query: 270 RGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLA 319 RG + AF +S + + +D R + + GH V ++ Sbjct: 158 RGEVLSLAFRKNSDQLYASCADFKIRTYSINQFSQLEILYGHHDIVEDIS 207 Score = 43.2 bits (100), Expect = 1e-04, Method: Composition-based stats. Identities = 15/68 (22%), Positives = 25/68 (36%), Gaps = 2/68 (2%) Query: 255 MTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGG--HQ 312 + + N E + A S D +Y+VT D +W E+ + + Sbjct: 99 IPTSKHEYENTTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRR 158 Query: 313 KAVVCLAF 320 V+ LAF Sbjct: 159 GEVLSLAF 166 >5WLC-LN nrPDB Length = 776 Score = 82.5 bits (202), Expect = 3e-16, Method: Composition-based stats. Identities = 41/242 (16%), Positives = 77/242 (31%), Gaps = 13/242 (5%) Query: 83 GVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQV-NAPINCVCLHP--- 138 NI + + G + IW+ R+ Q I + I +C Sbjct: 52 SHKSNINKLT--PSDLRLAIGRSNGNIEIWNPRNNWFQEMVIEGGKDRSIEGLCWSNVNG 109 Query: 139 NQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWN 198 L S + WDL T + I S I+ ++ G + + Sbjct: 110 ESLRLFSIGGSTVVTEWDLATGLPLRNYDCNSGVIWSISINDSQDKLSVGCDNGTVVLID 169 Query: 199 LTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTS--NFSLMT 256 ++GG G L T + L + D ++ CS D +IW + ++ Sbjct: 170 ISGGPGV----LEHDTILMRQEARVLTLAWKKDDFVIGGCS-DGRIRIWSAQKNDENMGR 224 Query: 257 ELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVV 316 L + + +W + + I + S + W + + + + H V+ Sbjct: 225 LLHTMKVDKAKKESTLVWSVIYLPRTDQIASGDSTGSIKFWDFQFATLNQSFKAHDADVL 284 Query: 317 CL 318 CL Sbjct: 285 CL 286 Score = 80.6 bits (197), Expect = 1e-15, Method: Composition-based stats. Identities = 39/310 (12%), Positives = 102/310 (32%), Gaps = 22/310 (7%) Query: 6 GTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQ-H 64 V + + L + G V W +G+ R + ++ + + ++ Sbjct: 105 SNVNGESLRLFSIGGSTVVTEWDLATGLPLRNYDCNSGVIWSISINDSQDKLSVGCDNGT 164 Query: 65 IRMYDLNSNNP--NPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSR----- 117 + + D++ + ++ + +D ++ G D RIW + Sbjct: 165 VVLIDISGGPGVLEHDTILMRQEARVLTLAWKKD-DFVIGGCSDGRIRIWSAQKNDENMG 223 Query: 118 ----NLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSI 173 ++ + + + + V P ++ GD +G+I WD + Q + + Sbjct: 224 RLLHTMKVDKAKKESTLVWSVIYLPRTDQIASGDSTGSIKFWDFQFATLNQSFKAHDADV 283 Query: 174 TSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRF--SPD 231 D D +Y+ + + ++ + + + + H S Sbjct: 284 LCLTTDTDNNYVFSAGVDRKIFQFSQNTNKSQKNNRWVNSSNRLLHGNDIRAICAYQSKG 343 Query: 232 STLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSD 291 + L + ++T I ++FS + + P + Q +V + S+ Sbjct: 344 ADFLVSGGVEKTLVINSLTSFSNGNYRKMPTVEPYSKN-------VLVNKEQRLVVSWSE 396 Query: 292 NLARLWCVET 301 + ++W + T Sbjct: 397 STVKIWTMGT 406 Score = 77.5 bits (189), Expect = 7e-15, Method: Composition-based stats. Identities = 45/302 (14%), Positives = 93/302 (30%), Gaps = 31/302 (10%) Query: 10 SDPVILATAGYD-HTVRFWQAHSG----ICTRTVQHQDSQVNALEVTPDRSMIAAAGYQH 64 +D + G D TV G + Q+++V L D +I Sbjct: 150 NDSQDKLSVGCDNGTVVLIDISGGPGVLEHDTILMRQEARVLTLAWKKDDFVIGGCSDGR 209 Query: 65 IRMYDLNSNNPNPIISYDG--------VNKNIASVGFHEDGRWMYTGGEDCTARIWDLRS 116 IR++ N+ N + + SV + + +G + + WD + Sbjct: 210 IRIWSAQKNDENMGRLLHTMKVDKAKKESTLVWSVIYLPRTDQIASGDSTGSIKFWDFQF 269 Query: 117 RNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQ----------LI 166 L +A + C+ + + I + T+ +++ L+ Sbjct: 270 ATLNQSFK-AHDADVLCLTTDTDNNYVFSAGVDRKIFQFSQNTNKSQKNNRWVNSSNRLL 328 Query: 167 PEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQC 226 ++ A+ A ++ + + +LT K+P Y+ Sbjct: 329 HGNDIRAICAYQSKGADFLVSGGVEKTLVINSLTSFSNGNYR------KMPTVEPYSKNV 382 Query: 227 RFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIV 286 + + L+ + S + T KIW S + + C+ S D Q +V Sbjct: 383 LVNKEQRLVVSWS-ESTVKIWTMGTDSSTEQNYKLVCKLTLKDDQNISTCSLSPDGQVLV 441 Query: 287 TA 288 Sbjct: 442 VG 443 Score = 40.1 bits (92), Expect = 0.001, Method: Composition-based stats. Identities = 21/106 (19%), Positives = 37/106 (34%), Gaps = 5/106 (4%) Query: 218 AHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCA 277 +H + P LA ++ +IW N + G S G W Sbjct: 52 SHKSNINKLT--PSDLRLAIGRSNGNIEIWNPRNNWFQE--MVIEGGKDRSIEGLCWS-N 106 Query: 278 FSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDS 323 +G+S + + + W + TG R Y + + ++ NDS Sbjct: 107 VNGESLRLFSIGGSTVVTEWDLATGLPLRNYDCNSGVIWSISINDS 152 >2P9P-C nrPDB Length = 372 Score = 81.7 bits (200), Expect = 4e-16, Method: Composition-based stats. Identities = 52/283 (18%), Positives = 103/283 (36%), Gaps = 25/283 (8%) Query: 44 QVNALEVTPDRSMIAAAGYQH-IRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYT 102 ++ DR+ IA H + +Y+ + N + N + V + D + T Sbjct: 10 PISCHAWNKDRTQIAICPNNHEVHIYEKSGNKWVQVHELKEHNGQVTGVDWAPDSNRIVT 69 Query: 103 GGEDCTARIWDLRSRNLQCQR-IFQVNAPINCVCLHPNQAELIVGDQSGAIHI--WDLKT 159 G D A +W L+ R + I ++N CV PN+ + VG S I I ++ + Sbjct: 70 CGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRWAPNEKKFAVGSGSRVISICYFEQEN 129 Query: 160 D--HNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKT--- 214 D + + ++ S P++ +AA + C +++ +E P Sbjct: 130 DWWVCKHIKKPIRSTVLSLDWHPNSVLLAAGSCDFKCRIFSAYIKEVEERPAPTPWGSKM 189 Query: 215 -------KIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGE 267 + + + FS + + +A S D T + + L+ ++ Sbjct: 190 PFGELMFESSSSCGWVHGVCFSANGSRVAWVSHDSTVCLADADKKMAVATLASET----- 244 Query: 268 SSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGG 310 + F +S +V A D L+ ++ K +GG Sbjct: 245 ---LPLLAVTFITESS-LVAAGHDCFPVLFTYDSAAGKLSFGG 283 Score = 79.8 bits (195), Expect = 2e-15, Method: Composition-based stats. Identities = 37/247 (14%), Positives = 79/247 (31%), Gaps = 17/247 (6%) Query: 87 NIASVGFHEDGRWMYTGGEDCTARIWD-LRSRNLQCQRIFQVNAPINCVCLHPNQAELIV 145 I+ +++D + + I++ ++ +Q + + N + V P+ ++ Sbjct: 10 PISCHAWNKDRTQIAICPNNHEVHIYEKSGNKWVQVHELKEHNGQVTGVDWAPDSNRIVT 69 Query: 146 GDQSGAIHIWDL--KTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGI 203 ++W L +T +I + P+ A + + + Sbjct: 70 CGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRWAPNEKKFAVGSGSRVISICYFEQEN 129 Query: 204 GDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSI--- 260 V + I K L + P+S LLA S D C+I+ + + Sbjct: 130 DWWVCKHIKKPIRST----VLSLDWHPNSVLLAAGSCDFKCRIFSAYIKEVEERPAPTPW 185 Query: 261 -------KSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQK 313 + SS GW+ G FS + + S D+ L + Sbjct: 186 GSKMPFGELMFESSSSCGWVHGVCFSANGSRVAWVSHDSTVCLADADKKMAVATLASETL 245 Query: 314 AVVCLAF 320 ++ + F Sbjct: 246 PLLAVTF 252 Score = 64.4 bits (155), Expect = 7e-11, Method: Composition-based stats. Identities = 33/254 (12%), Positives = 80/254 (31%), Gaps = 32/254 (12%) Query: 9 GSDPVILATAGYDHTVRFWQA--HSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQ-HI 65 D +A +H V ++ + + ++ + QV ++ PD + I G + Sbjct: 17 NKDRTQIAICPNNHEVHIYEKSGNKWVQVHELKEHNGQVTGVDWAPDSNRIVTCGTDRNA 76 Query: 66 RMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARI--WDLRSRNLQCQR 123 ++ L P + +N+ V + + + G I ++ + C+ Sbjct: 77 YVWTLKGRTWKPTLVILRINRAARCVRWAPNEKKFAVGSGSRVISICYFEQENDWWVCKH 136 Query: 124 IFQ-VNAPINCVCLHPNQAELIVGDQSGAIHIWDLK----TDHNEQLIPEPEVS------ 172 I + + + + + HPN L G I+ + ++ Sbjct: 137 IKKPIRSTVLSLDWHPNSVLLAAGSCDFKCRIFSAYIKEVEERPAPTPWGSKMPFGELMF 196 Query: 173 --------ITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYAL 224 + + S +A V+ + + + + + + T L Sbjct: 197 ESSSSCGWVHGVCFSANGSRVAWVSHDSTVCL--------ADADKKMAVATLASETLPLL 248 Query: 225 QCRFSPDSTLLATC 238 F +S+L+A Sbjct: 249 AVTFITESSLVAAG 262 Score = 57.5 bits (137), Expect = 8e-09, Method: Composition-based stats. Identities = 33/301 (10%), Positives = 74/301 (24%), Gaps = 58/301 (19%) Query: 9 GSDPVILATAGYDHTVRFW--QAHSGICTRTVQHQDSQVNALEVTPD-RSMIAAAGYQHI 65 D + T G D W + + T + + + P+ + +G + I Sbjct: 61 APDSNRIVTCGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRWAPNEKKFAVGSGSRVI 120 Query: 66 RM--YDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIW-----DLRSRN 118 + ++ ++ + + S+ +H + + G D RI+ ++ R Sbjct: 121 SICYFEQENDWWVCKHIKKPIRSTVLSLDWHPNSVLLAAGSCDFKCRIFSAYIKEVEERP 180 Query: 119 LQCQR------------IFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLI 166 ++ VC N + + + + D + Sbjct: 181 APTPWGSKMPFGELMFESSSSCGWVHGVCFSANGSRVAWVSHDSTVCLADADKKMAVATL 240 Query: 167 PEPEVSITSAHIDPDASYMAAV-----------NSTGNC--------------------- 194 + + + ++S +AA ++ G Sbjct: 241 ASETLPLLAVTFITESSLVAAGHDCFPVLFTYDSAAGKLSFGGRLDVPKQSSQRGLTARE 300 Query: 195 YVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDST----LLATCSADQTCKIWRTS 250 NL E + H Q T D IW Sbjct: 301 RFQNLDKKASSEGSAAAGAGLDSLHKNSVSQISVLSGGKAKCSQFCTTGMDGGMSIWDVR 360 Query: 251 N 251 + Sbjct: 361 S 361 >6F1U-h nrPDB Length = 612 Score = 81.3 bits (199), Expect = 6e-16, Method: Composition-based stats. Identities = 33/263 (12%), Positives = 82/263 (31%), Gaps = 36/263 (13%) Query: 88 IASVGFHEDGRWMYTGGE----------DCTARIWDLRSRNLQCQRIFQVNAPINCVCLH 137 ++ + + + D A +W+++ + + +F + + Sbjct: 256 VSCLDWSSQYPELLVASYNNNEDAPHEPDGVALVWNMKYKKTTPEYVFHCQSAVMSATFA 315 Query: 138 PNQAELIVGD-QSGAIHIWDLKTDHNEQLIPE--------PEVSITSAHIDPDASYMAAV 188 L+VG SG I +WD +++ + V + +A + ++ Sbjct: 316 KFHPNLVVGGTYSGQIVLWDNRSNKRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLISI 375 Query: 189 NSTGNCYVW--NLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKI 246 ++ G W ++ D + + ++K A T + D S + + Sbjct: 376 STDGKICSWSLDMLSHPQDSMELVHKQSKAVAVTSMSFPVG---DVNNFVVGSEEGSVY- 431 Query: 247 WRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSG------DSQYIVTASSDNLARLWCVE 300 + E +G + G S VT+S D +LW + Sbjct: 432 -----TACRHGSKAGISEMFEGHQGPITGIHCHAAVGAVDFSHLFVTSSFDWTVKLWSTK 486 Query: 301 TGEIKREYGGHQKAVVCLAFNDS 323 + + + V + ++ + Sbjct: 487 NNKPLYSFEDNAGYVYDVMWSPT 509 Score = 71.3 bits (173), Expect = 5e-13, Method: Composition-based stats. Identities = 30/264 (11%), Positives = 69/264 (26%), Gaps = 33/264 (12%) Query: 12 PVILATAGYDHTVRFWQAHSGI---CTRT---VQHQDSQVNALEVTPDRS---MIAAAGY 62 P ++ Y + W S RT V + V ++ +I+ + Sbjct: 319 PNLVVGGTYSGQIVLWDNRSNKRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLISISTD 378 Query: 63 QHIRMYDLNSNNP----NPIISYDGVNKNIASVGF-----------HEDGRWMYTGGEDC 107 I + L+ + ++ + S+ F E+G Sbjct: 379 GKICSWSLDMLSHPQDSMELVHKQSKAVAVTSMSFPVGDVNNFVVGSEEGSVYTACRHGS 438 Query: 108 TARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIP 167 A I ++ + +A + V + + +W K + Sbjct: 439 KAGISEMFEGHQGPITGIHCHAAVGAVDFS---HLFVTSSFDWTVKLWSTKNNKPLYSFE 495 Query: 168 EPEVSITSAHIDPDASYMAAVNST-GNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQC 226 + + P + A G +WNL + + + Sbjct: 496 DNAGYVYDVMWSPTHPALFACVDGMGRLDLWNLNNDTEVPTASISVEG-----NPALNRV 550 Query: 227 RFSPDSTLLATCSADQTCKIWRTS 250 R++ +A ++ I+ Sbjct: 551 RWTHSGREIAVGDSEGQIVIYDVG 574 Score = 70.6 bits (171), Expect = 9e-13, Method: Composition-based stats. Identities = 50/292 (17%), Positives = 90/292 (30%), Gaps = 46/292 (15%) Query: 42 DSQVNALEVTPDRSMIAAAGYQH-----------IRMYDLNSNNPNPIISYDGVNKNIAS 90 V+ L+ + + A Y + ++++ P + + S Sbjct: 253 HRVVSCLDWSSQYPELLVASYNNNEDAPHEPDGVALVWNMKYKKTTPEYVFHC-QSAVMS 311 Query: 91 VGFHEDGRWMYTGGE-DCTARIWDLRS-RNLQCQRI----FQVNAPINCVCL--HPNQAE 142 F + + GG +WD RS + QR P+ CV + N Sbjct: 312 ATFAKFHPNLVVGGTYSGQIVLWDNRSNKRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHN 371 Query: 143 LIVGDQSGAIHIWDLK----TDHNEQLIPEPEVSITSAHIDP---DASYMAAVNSTGNCY 195 LI G I W L + +L+ + ++ + D + + G+ Y Sbjct: 372 LISISTDGKICSWSLDMLSHPQDSMELVHKQSKAVAVTSMSFPVGDVNNFVVGSEEGSVY 431 Query: 196 VWNLTGGIGDEVTQLI-----PKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTS 250 G ++++ P T I H FS L T S D T K+W T Sbjct: 432 T-ACRHGSKAGISEMFEGHQGPITGIHCHA-AVGAVDFS---HLFVTSSFDWTVKLWSTK 486 Query: 251 NFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSD-NLARLWCVET 301 N + E + G+++ +S + LW + Sbjct: 487 NNKPLYSF--------EDNAGYVYDVMWSPTHPALFACVDGMGRLDLWNLNN 530 >3I2N-A nrPDB Length = 357 Score = 79.4 bits (194), Expect = 2e-15, Method: Composition-based stats. Identities = 46/271 (16%), Positives = 89/271 (32%), Gaps = 34/271 (12%) Query: 56 MIAAAGYQ-HIRMYDLNSNNPNPIISYDGVNKNIASVGFHED------GRWMYTGGEDCT 108 +A + ++ +++L + P+ S G + I ++ + TG D T Sbjct: 82 YLATGDFGGNLHIWNLEA-PEMPVYSVKGHKEIINAIDGIGGLGIGEGAPEIVTGSRDGT 140 Query: 109 ARIWDLRSRNLQCQR----IFQVNAPINCVCL----HPNQAELIVGDQSGAIHIWDLKTD 160 ++WD R ++ + V + + + G +G I ++DL+ Sbjct: 141 VKVWDPRQKDDPVANMEPVQGENKRDCWTVAFGNAYNQEERVVCAGYDNGDIKLFDLRNM 200 Query: 161 --HNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPA 218 E I S+ D + + A + G +V+++ T+ A Sbjct: 201 ALRWETNIKNGVCSLEFDRKDISMNKLVATSLEGKFHVFDMRT---QHPTKGFASVSEKA 257 Query: 219 HTRYALQCRFSP-DSTLLATCSADQTCKIWRTSN---FSLMTELSIKSGNPGES------ 268 H Q R P + L T +W+ S I+ G G Sbjct: 258 HKSTVWQVRHLPQNRELFLTAGGAGGLHLWKYEYPIQRSKKDSEGIEMGVAGSVSLLQNV 317 Query: 269 --SRGWMWGCAFSGDSQYIVTASS-DNLARL 296 S + +S D + + SS D R+ Sbjct: 318 TLSTQPISSLDWSPDKRGLCVCSSFDQTVRV 348 Score = 74.8 bits (182), Expect = 5e-14, Method: Composition-based stats. Identities = 41/278 (14%), Positives = 98/278 (35%), Gaps = 40/278 (14%) Query: 6 GTVGSDPVILATAGYDHTVRFWQAHS-GICTRTVQHQDSQVNALEVTPDR-------SMI 57 G LAT + + W + + +V+ +NA++ ++ Sbjct: 74 GATSLQQRYLATGDFGGNLHIWNLEAPEMPVYSVKGHKEIINAIDGIGGLGIGEGAPEIV 133 Query: 58 AAAGYQHIRMYDLNSNNPNPIISYD---GVNK-NIASVGF----HEDGRWMYTGGEDCTA 109 + ++++D +P+ + + G NK + +V F +++ R + G ++ Sbjct: 134 TGSRDGTVKVWDPR-QKDDPVANMEPVQGENKRDCWTVAFGNAYNQEERVVCAGYDNGDI 192 Query: 110 RIWDLRSRNLQCQRIFQVNAPINCVCLHPNQ---AELIVGDQSGAIHIWDLKTDHNEQLI 166 +++DLR+ L+ + + + + +L+ G H++D++T H + Sbjct: 193 KLFDLRNMALRWETNIKNG--VCSLEFDRKDISMNKLVATSLEGKFHVFDMRTQHPTKGF 250 Query: 167 -----PEPEVSITSAHIDPDAS-YMAAVNSTGNCYVW-----------NLTGGIGDEVTQ 209 + ++ P G ++W + G Sbjct: 251 ASVSEKAHKSTVWQVRHLPQNRELFLTAGGAGGLHLWKYEYPIQRSKKDSEGIEMGVAGS 310 Query: 210 LIPKTKIPAHTRYALQCRFSPDSTLLATCSA-DQTCKI 246 + + T+ +SPD L CS+ DQT ++ Sbjct: 311 VSLLQNVTLSTQPISSLDWSPDKRGLCVCSSFDQTVRV 348 Score = 48.6 bits (114), Expect = 3e-06, Method: Composition-based stats. Identities = 21/141 (14%), Positives = 41/141 (29%), Gaps = 9/141 (6%) Query: 164 QLIPEPEVSITSAHIDPDASYMAAVN----STGNCYVWNLTGGIGDEVTQLIPKTKIPAH 219 + ++ P ++ + TG ++ + G + ++ I Sbjct: 12 HIQKGFNYTVFDCKWVPCSAKFVTMGNFARGTGVIQLYEIQHGDLKLLREIEKAKPI--- 68 Query: 220 TRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFS 279 + S LAT IW M S+K ++ + G Sbjct: 69 -KCGTFGATSLQQRYLATGDFGGNLHIWNLEAPE-MPVYSVKGHKEIINAIDGIGGLGIG 126 Query: 280 GDSQYIVTASSDNLARLWCVE 300 + IVT S D ++W Sbjct: 127 EGAPEIVTGSRDGTVKVWDPR 147 >4PSX-B nrPDB Length = 401 Score = 79.4 bits (194), Expect = 2e-15, Method: Composition-based stats. Identities = 38/280 (13%), Positives = 86/280 (30%), Gaps = 31/280 (11%) Query: 41 QDSQVNALEVTPDRSMIAAA--GYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHE--D 96 + ++ P I A G +Y S + + N ++ F Sbjct: 117 HEEEITRARYMPQDPNIVATINGQGTTFLY---SRSEGLQSTLKFHKDNGYALSFSTLVK 173 Query: 97 GRWMYTGGEDCTARIWDLRSRNLQCQRIFQ----VNAPINCVCLHP-NQAELIVGDQSGA 151 GR + +G +D T +W++ S + + + IN H N+ + Sbjct: 174 GRLL-SGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSL 232 Query: 152 IHIWDLKTDHNEQLIPEPEVSITSAHID-PDASYMAAVNSTGNCYVWNLTGGIGDEVTQL 210 + I D++ ++ + + ++ +AA Y+++L Sbjct: 233 LKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRN-------MK 285 Query: 211 IPKTKIPAHTRYALQCRFSP--DSTLLATCSADQTCKIWRTSNFSLMTEL------SIKS 262 P + H FS D ++++ S D +W + Sbjct: 286 EPLHHMSGHEDAVNNLEFSTHVDGVVVSSGS-DNRLMMWDLKQIGAEQTPDDAEDGVPEL 344 Query: 263 GNPGESSRGWMWGCAFSGDSQYIV-TASSDNLARLWCVET 301 R + + ++V +A +N+ ++W Sbjct: 345 IMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCSH 384 Score = 69.8 bits (169), Expect = 1e-12, Method: Composition-based stats. Identities = 36/216 (16%), Positives = 70/216 (32%), Gaps = 30/216 (13%) Query: 15 LATAGYDHTVRFWQAHSG----ICTRTVQH-QDSQVNALEVTP-DRSMIAAAGYQHI-RM 67 L + DHTV W+ SG RT +N + ++ + + ++ Sbjct: 176 LLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKI 235 Query: 68 YDLNSNNPNPIISYDGVNKN--IASVGF-HEDGRWMYTGGEDCTARIWDLRSRNLQCQRI 124 D+ +NN + D V ++ F H + G D ++DLR+ + Sbjct: 236 NDVRANNT----TIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHM 291 Query: 125 FQVNAPINCVCLHPN-QAELIVGDQSGAIHIWDLKTDHNEQLIP--------------EP 169 +N + + ++ + +WDLK EQ Sbjct: 292 SGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGH 351 Query: 170 EVSITSAHIDPDASYMAAVNSTGNC-YVWNLTGGIG 204 S+ ++P ++ A N VW + + Sbjct: 352 RSSVNDFDLNPQIPWLVASAEEENILQVWKCSHSLP 387 Score = 64.0 bits (154), Expect = 9e-11, Method: Composition-based stats. Identities = 31/216 (14%), Positives = 65/216 (30%), Gaps = 19/216 (8%) Query: 117 RNLQCQRIFQVNAPINCVCLHPNQAELIVG-DQSGAIHIWDLKTDHNEQLIPEPEVSITS 175 N++ ++ I P ++ + G ++ + + + + + Sbjct: 107 SNIRITAKYEHEEEITRARYMPQDPNIVATINGQGTTFLYSRSEG-LQSTLKFHKDNGYA 165 Query: 176 AHIDPDAS-YMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSP-DST 233 + + + +W + G +T H+ ++ + Sbjct: 166 LSFSTLVKGRLLSGSDDHTVALWEVGSGGDPT---KPVRTWNDLHSDIINDNKWHNFNKD 222 Query: 234 LLATCSADQTCKIWRT-SNFSLMTELSIKSGNPGESSRGWMWGCAFSG-DSQYIVTASSD 291 L T S D KI +N + + + AFS S + A D Sbjct: 223 LFGTVSEDSLLKINDVRANNTTIDTVK---------CPQPFNTLAFSHHSSNLLAAAGMD 273 Query: 292 NLARLWCVET-GEIKREYGGHQKAVVCLAFNDSVLG 326 + L+ + E GH+ AV L F+ V G Sbjct: 274 SYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDG 309 Score = 34.7 bits (78), Expect = 0.048, Method: Composition-based stats. Identities = 10/71 (14%), Positives = 26/71 (36%), Gaps = 16/71 (22%) Query: 14 ILATAGYDHTVRFW------------QAHSGI--CTRTVQHQDSQVNALEVTPDRSMIAA 59 ++ ++G D+ + W A G+ S VN ++ P + A Sbjct: 310 VVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVA 369 Query: 60 AGYQH--IRMY 68 + + ++++ Sbjct: 370 SAEEENILQVW 380 >5M89-A nrPDB Length = 329 Score = 78.7 bits (192), Expect = 3e-15, Method: Composition-based stats. Identities = 36/235 (15%), Positives = 74/235 (31%), Gaps = 28/235 (11%) Query: 57 IAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRS 116 + +Y + +N + + + + + G + G +++D Sbjct: 67 AVGGLDGKLDIYSVVANKVERTLDI---GEPVTATEWT--GTKVVIGTAKGWVKVYDAGR 121 Query: 117 RNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEP-EVSITS 175 + Q P+ + +HP L + +DL+T E++ + ++T+ Sbjct: 122 ESATFQT---HAGPVTGLAVHPGGRILASVGVDKSFVFYDLETG--ERVARGYADAALTT 176 Query: 176 AHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLL 235 PD + AA TG+ V++ T E L FS + Sbjct: 177 CAFHPDGNLFAAGTQTGHILVFHTTTLEQAESFPL---------GTPIQALAFSENGFWF 227 Query: 236 A-TCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTAS 289 A T + I+ S + E G + ++ QY+ T Sbjct: 228 AATGKGTSSVTIFDLRK-------SGAAAAVKELQTGEVLSISWDYTGQYLATGG 275 Score = 74.8 bits (182), Expect = 4e-14, Method: Composition-based stats. Identities = 28/234 (11%), Positives = 69/234 (29%), Gaps = 26/234 (11%) Query: 92 GFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGA 151 + GG D I+ + + +R + P+ ++++G G Sbjct: 58 SLDLENECAAVGGLDGKLDIYSV--VANKVERTLDIGEPVTATEW--TGTKVVIGTAKGW 113 Query: 152 IHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLI 211 + ++D +T + P +A+V + ++L G Sbjct: 114 VKVYDA--GRESATFQTHAGPVTGLAVHPGGRILASVGVDKSFVFYDLETGERVARGYA- 170 Query: 212 PKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRG 271 C F PD L A + ++ T+ + + Sbjct: 171 --------DAALTTCAFHPDGNLFAAGTQTGHILVFHTTTLEQAESFPLGT--------- 213 Query: 272 WMWGCAFSGDSQYI-VTASSDNLARLWCVE-TGEIKREYGGHQKAVVCLAFNDS 323 + AFS + + T + ++ + +G V+ ++++ + Sbjct: 214 PIQALAFSENGFWFAATGKGTSSVTIFDLRKSGAAAAVKELQTGEVLSISWDYT 267 Score = 60.2 bits (144), Expect = 1e-09, Method: Composition-based stats. Identities = 33/189 (17%), Positives = 64/189 (33%), Gaps = 10/189 (5%) Query: 12 PVILATAGYDHTVRFWQAHSGICTRTVQH-QDSQVNALEVTPDRSMIAAAG-YQHIRMYD 69 ILA+ G D + F+ +G R + D+ + PD ++ AA HI ++ Sbjct: 142 GRILASVGVDKSFVFYDLETGE--RVARGYADAALTTCAFHPDGNLFAAGTQTGHILVFH 199 Query: 70 LNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGED-CTARIWDLRSRNLQCQRIFQVN 128 + I ++ F E+G W G+ + I+DLR Sbjct: 200 TTTLEQAESFPL---GTPIQALAFSENGFWFAATGKGTSSVTIFDLRKSGAAAAVKELQT 256 Query: 129 APINCVCLHPNQAELIVGDQSG-AIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAA 187 + + L G +G + ++ T + + + + +A + Sbjct: 257 GEVLSISWDYTGQYLATGGGTGVTVQMYTKATKSWSEPVRLG-MPVVGVKWGGEAKRLVV 315 Query: 188 VNSTGNCYV 196 V+ G V Sbjct: 316 VSREGVVSV 324 >5A9Q-7 nrPDB Length = 360 Score = 78.3 bits (191), Expect = 5e-15, Method: Composition-based stats. Identities = 41/305 (13%), Positives = 94/305 (30%), Gaps = 49/305 (16%) Query: 15 LATAGYDHTVRFWQAH---SGICTRTVQHQDSQVNALEV-TPD-RSMIAAAG-YQHIRMY 68 +AT D +V+ W CT + + V + P+ ++A+ + ++ Sbjct: 27 MATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEFGQVLASCSFDRTAAVW 86 Query: 69 DLNSNNPNPIISYDGV----------NKNIASVGFHED--GRWMYTGGEDCTARIWDLRS 116 + N + ++ V F G + T D RI++ Sbjct: 87 EEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLMLATCSADGIVRIYEAPD 146 Query: 117 RNLQCQRIFQVNAPI----NCVCLHPNQAE-----LIVGDQSGA------IHIWDLKTDH 161 Q Q +C+ +P+ + + VG + + I++ + Sbjct: 147 VMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSPMIAVGSDDSSPNAMAKVQIFEYNENT 206 Query: 162 NEQ----LIPEPEVSITSAHIDPD--ASYMAAVNSTGNCYVW-------NLTGGIGDEVT 208 + + + P+ S+ +T + ++ LT G Sbjct: 207 RKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAIATKDVRIFTLKPVRKELTSSGGPTKF 266 Query: 209 QLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWR---TSNFSLMTELSIKSGNP 265 ++ + H + ++ T+LA+ D ++W+ N+ L Sbjct: 267 EIHIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWKANYMDNWKCTGILKGNGSPV 326 Query: 266 GESSR 270 SS+ Sbjct: 327 NGSSQ 331 Score = 77.1 bits (188), Expect = 1e-14, Method: Composition-based stats. Identities = 45/324 (13%), Positives = 109/324 (33%), Gaps = 53/324 (16%) Query: 41 QDSQVNALEVT-PDRSMIAAAGYQHIRMYD-LNSNNPNPIISYDGVNKNIASVGF-HED- 96 ++ + R M + Q ++++D S + + S+ + ++ V + H + Sbjct: 11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEF 70 Query: 97 GRWMYTGGEDCTARIWD---------LRSRNLQCQRIFQVNA--PINCVCLHPN--QAEL 143 G+ + + D TA +W+ LR ++ +R V++ + V P L Sbjct: 71 GQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLML 130 Query: 144 IVGDQSGAIHIWDLKT--DHNEQLIPEP---EVSITSAHIDPDASY----MAAVNSTG-- 192 G + I++ + ++ + ++S + +P +S M AV S Sbjct: 131 ATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSPMIAVGSDDSS 190 Query: 193 -----NCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDS----TLLATCSADQT 243 ++ + + + T F+P+ +LA + D Sbjct: 191 PNAMAKVQIFEYN----ENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAIATKD-- 244 Query: 244 CKIWRTSNFSLM-------TELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARL 296 +I+ T+ I ++ +W +++ + ++ D RL Sbjct: 245 VRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRL 304 Query: 297 WC---VETGEIKREYGGHQKAVVC 317 W ++ + G+ V Sbjct: 305 WKANYMDNWKCTGILKGNGSPVNG 328 Score = 54.0 bits (128), Expect = 9e-08, Method: Composition-based stats. Identities = 24/119 (20%), Positives = 40/119 (33%), Gaps = 7/119 (5%) Query: 209 QLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGES 268 + ++ H F +ATCS+DQ+ K+W S ++ Sbjct: 1 MFVARSIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKS-----ESGDWHCTASWKT 55 Query: 269 SRGWMWGCAFS--GDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDSVL 325 G +W ++ Q + + S D A +W GE + G V DS Sbjct: 56 HSGSVWRVTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRT 114 Score = 30.9 bits (68), Expect = 0.74, Method: Composition-based stats. Identities = 13/42 (30%), Positives = 20/42 (47%), Gaps = 3/42 (7%) Query: 9 GSDPVILATAGYDHTVRFWQA---HSGICTRTVQHQDSQVNA 47 +LA++G D VR W+A + CT ++ S VN Sbjct: 287 NITGTVLASSGDDGCVRLWKANYMDNWKCTGILKGNGSPVNG 328 >6E29-D nrPDB Length = 345 Score = 77.5 bits (189), Expect = 7e-15, Method: Composition-based stats. Identities = 37/322 (11%), Positives = 95/322 (29%), Gaps = 39/322 (12%) Query: 9 GSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQ-HIRM 67 LA+ D TV W + R ++ + +L + + +A + + Sbjct: 34 NRKGDFLASGRVDGTVVIWDLETMGVARKLRGHSKNITSLSWSRCGRYLLSACQGWKVIL 93 Query: 68 YDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQV 127 +DL + + + H + + + Sbjct: 94 WDLQDGKRYREVRFR---APVYGAELHPWNHHQFAAA--------LFEDQPMLVDIT--- 139 Query: 128 NAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAA 187 P+ + P+ + + A+ +Q + + T+ ++ A Sbjct: 140 -EPVEVRYVLPSVPKRTSTETDPALR--------EKQAKEDAKHMTTAIVYTASGDHLLA 190 Query: 188 VNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIW 247 + G + + ++I KI + R + L + D+ + + Sbjct: 191 GTTKGRLNIID------ARTREIIYSEKIAS--GIITTLRLTESGRELLVNAQDRIIRTF 242 Query: 248 RTSNFSLMT------ELSIKSGNPGESSRGWMWGCAFSGDSQYI-VTASSDNLARLWCVE 300 N S +L ++ +R AFS +Y+ + +++ +W Sbjct: 243 IVPNLSAADLDPDTIQLPLEHKFQDVVNRLSWNHVAFSATGEYVAASTYNNHELYIWERG 302 Query: 301 TGEIKREYGGHQKAVVCLAFND 322 G + R G ++ + ++ Sbjct: 303 HGSLVRMLEGPKEEQGVIEWHP 324 Score = 67.5 bits (163), Expect = 8e-12, Method: Composition-based stats. Identities = 27/210 (12%), Positives = 56/210 (26%), Gaps = 25/210 (11%) Query: 112 WDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEV 171 + L+ + CV + L G G + IWDL+T + + Sbjct: 10 YLLQDYPENITNTIRSGHS-TCVRFNRKGDFLASGRVDGTVVIWDLETMGVARKLRGHSK 68 Query: 172 SITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPD 231 +ITS Y+ + +W+L G + + P Sbjct: 69 NITSLSWSRCGRYLLSACQGWKVILWDLQDG---------KRYREVRFRAPVYGAELHPW 119 Query: 232 STLLATCS--ADQTCKIWRTSNFSLMTELSIKSGNPG-------------ESSRGWMWGC 276 + + DQ + T + L E ++ Sbjct: 120 NHHQFAAALFEDQPMLVDITEPVEVRYVLPSVPKRTSTETDPALREKQAKEDAKHMTTAI 179 Query: 277 AFSGDSQYIVTASSDNLARLWCVETGEIKR 306 ++ +++ ++ + T EI Sbjct: 180 VYTASGDHLLAGTTKGRLNIIDARTREIIY 209 Score = 63.2 bits (152), Expect = 1e-10, Method: Composition-based stats. Identities = 29/235 (12%), Positives = 72/235 (30%), Gaps = 28/235 (11%) Query: 82 DGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQA 141 G + V F+ G ++ +G D T IWDL + + +++ + I + Sbjct: 25 SGHS---TCVRFNRKGDFLASGRVDGTVVIWDLETMGV-ARKLRGHSKNITSLSWSRCGR 80 Query: 142 ELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDP------------DASYMAAVN 189 L+ Q + +WDL+ + + + A + P D + + Sbjct: 81 YLLSACQGWKVILWDLQDGKRYREVRF-RAPVYGAELHPWNHHQFAAALFEDQPMLVDIT 139 Query: 190 STGNCY--VWNLTGGIGDEVTQLIPKTKIPAHTRYA-LQCRFSPDSTLLATCSADQTCKI 246 + ++ E + + + ++ ++ L + I Sbjct: 140 EPVEVRYVLPSVPKRTSTETDPALREKQAKEDAKHMTTAIVYTASGDHLLAGTTKGRLNI 199 Query: 247 WRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVET 301 ++ I SG + + + ++ + D + R + V Sbjct: 200 IDARTREIIYSEKIASG--------IITTLRLTESGRELLVNAQDRIIRTFIVPN 246 Score = 52.5 bits (124), Expect = 2e-07, Method: Composition-based stats. Identities = 27/175 (15%), Positives = 57/175 (32%), Gaps = 16/175 (9%) Query: 41 QDSQVNALEVTPDRSMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWM 100 A+ T + A + R+ +++ I S + I ++ E GR + Sbjct: 172 AKHMTTAIVYTASGDHLLAGTTKG-RLNIIDARTREIIYSEKIASGIITTLRLTESGREL 230 Query: 101 YTGGEDCTARIW--------DLRSRNLQCQRIFQVNAPIN-----CVCLHPNQAELIVGD 147 +D R + DL +Q + +N V + Sbjct: 231 LVNAQDRIIRTFIVPNLSAADLDPDTIQLPLEHKFQDVVNRLSWNHVAFSATGEYVAAST 290 Query: 148 QSG-AIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVN-STGNCYVWNLT 200 + ++IW+ +++ P+ P + +AA TG +W++T Sbjct: 291 YNNHELYIWERGHGSLVRMLEGPKEEQGVIEWHPHRALLAACGLETGRINIWSVT 345 Score = 49.8 bits (117), Expect = 2e-06, Method: Composition-based stats. Identities = 11/51 (21%), Positives = 23/51 (45%) Query: 271 GWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFN 321 G F+ ++ + D +W +ET + R+ GH K + L+++ Sbjct: 26 GHSTCVRFNRKGDFLASGRVDGTVVIWDLETMGVARKLRGHSKNITSLSWS 76 Score = 33.6 bits (75), Expect = 0.13, Method: Composition-based stats. Identities = 12/60 (20%), Positives = 28/60 (46%), Gaps = 2/60 (3%) Query: 14 ILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQH--IRMYDLN 71 + A+ +H + W+ G R ++ + +E P R+++AA G + I ++ + Sbjct: 286 VAASTYNNHELYIWERGHGSLVRMLEGPKEEQGVIEWHPHRALLAACGLETGRINIWSVT 345 >3DWL-C nrPDB Length = 377 Score = 73.3 bits (178), Expect = 1e-13, Method: Composition-based stats. Identities = 35/252 (13%), Positives = 78/252 (30%), Gaps = 21/252 (8%) Query: 54 RSMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWD 113 + + +Y+ + N ++ +K + V + + T +D A +++ Sbjct: 24 TEFVTTTATNQVELYEQDGNGWKHARTFSDHDKIVTCVDWAPKSNRIVTCSQDRNAYVYE 83 Query: 114 LRSRNL--QCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEP-- 169 R Q + ++N V PN+ + VG + I + N+ + + Sbjct: 84 KRPDGTWKQTLVLLRLNRAATFVRWSPNEDKFAVGSGARVISV-CYFEQENDWWVSKHLK 142 Query: 170 ---EVSITSAHIDPDASYMAAVNSTGNCYVW-----NLTGGIGDEVTQLIPKTKIPAHT- 220 +I S P+ +AA + YV ++ V Sbjct: 143 RPLRSTILSLDWHPNNVLLAAGCADRKAYVLSAYVRDVDAKPEASVWGSRLPFNTVCAEY 202 Query: 221 ---RYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCA 277 + FSP LA D + I + E ++ + S+ + Sbjct: 203 PSGGWVHAVGFSPSGNALAYAGHDSSVTI----AYPSAPEQPPRALITVKLSQLPLRSLL 258 Query: 278 FSGDSQYIVTAS 289 ++ +S + Sbjct: 259 WANESAIVAAGY 270 Score = 71.7 bits (174), Expect = 4e-13, Method: Composition-based stats. Identities = 29/218 (13%), Positives = 64/218 (29%), Gaps = 17/218 (7%) Query: 92 GFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQ-VNAPINCVCLHPNQAELIVGDQSG 150 F+ T +++ + R F + + CV P ++ Q Sbjct: 18 AFNSQRTEFVTTTATNQVELYEQDGNGWKHARTFSDHDKIVTCVDWAPKSNRIVTCSQDR 77 Query: 151 AIHIWDLKTD---HNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEV 207 ++++ + D ++ + T P+ A + V V Sbjct: 78 NAYVYEKRPDGTWKQTLVLLRLNRAATFVRWSPNEDKFAVGSGARVISVCYFEQENDWWV 137 Query: 208 TQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTE---------L 258 ++ + + L + P++ LLA AD+ + + + L Sbjct: 138 SKHLKRPLRST----ILSLDWHPNNVLLAAGCADRKAYVLSAYVRDVDAKPEASVWGSRL 193 Query: 259 SIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARL 296 + S GW+ FS + A D+ + Sbjct: 194 PFNTVCAEYPSGGWVHAVGFSPSGNALAYAGHDSSVTI 231 Score = 31.7 bits (70), Expect = 0.49, Method: Composition-based stats. Identities = 12/71 (16%), Positives = 22/71 (30%), Gaps = 6/71 (8%) Query: 227 RFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIV 286 F+ T T +A +++ K + ++ S IV Sbjct: 18 AFNSQRTEFVTTTATNQVELYEQDGN------GWKHARTFSDHDKIVTCVDWAPKSNRIV 71 Query: 287 TASSDNLARLW 297 T S D A ++ Sbjct: 72 TCSQDRNAYVY 82 >3JB9-S nrPDB Length = 488 Score = 71.3 bits (173), Expect = 6e-13, Method: Composition-based stats. Identities = 33/150 (22%), Positives = 60/150 (40%), Gaps = 8/150 (5%) Query: 42 DSQVNALEVTPDRSMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMY 101 D +VN L+ P + AA + ++ L S N ++ I S+ H DG Sbjct: 295 DEKVNFLQAHPSGEYLLAASNEKCYIFSLKSQVYNITVAQH-----ITSLAVHPDGNLFV 349 Query: 102 TGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGD-QSGAIHIWDLKTD 160 G E+ R ++ S N + + ++P+ + N L+V I IWDL+ Sbjct: 350 AGLENGELRFFETSSGN-ELTKFGPHSSPVKTLQFGENGYWLVVTTNDDSDIFIWDLRKS 408 Query: 161 HNEQLIPEPEVSITSAHIDPDASYMAAVNS 190 Q IP + + +D + + + + Sbjct: 409 ELVQKIPLQTK-VAAVSLDITSQLLVSSDG 437 Score = 51.3 bits (121), Expect = 5e-07, Method: Composition-based stats. Identities = 23/184 (12%), Positives = 54/184 (29%), Gaps = 18/184 (9%) Query: 137 HPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYV 196 P + ++ + D++++ ++ ++ S AV + + Sbjct: 218 SPENSSFVLCLHKDELLCLDIQSNSTLKIFEG-----SALACCWLTSSKIAVATADAISI 272 Query: 197 WNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMT 256 + + P + IP + + P L S ++ C I+ + Sbjct: 273 FEFPVSSSGLQSVGEPTSSIPIDEK-VNFLQAHPSGEYLLAASNEK-CYIFSLKSQVYNI 330 Query: 257 ELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVV 316 ++ + A D V + R + +G ++G H V Sbjct: 331 TVAQH-----------ITSLAVHPDGNLFVAGLENGELRFFETSSGNELTKFGPHSSPVK 379 Query: 317 CLAF 320 L F Sbjct: 380 TLQF 383 >5WLC-LW nrPDB Length = 554 Score = 68.6 bits (166), Expect = 4e-12, Method: Composition-based stats. Identities = 31/233 (13%), Positives = 68/233 (29%), Gaps = 16/233 (6%) Query: 48 LEVTPDR-SMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGED 106 ++ + ++ H+ D + S + ++ ++ + Sbjct: 116 IKYAKNGTHLLITGRKGHVASMDWRKGQ-LRAELFLNETC--HSATYLQNEQYFAVAQKK 172 Query: 107 CTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLI 166 T I+D L + + + P L+ ++G + D+ T + Sbjct: 173 YTF-IYDHEGTELH---RLKQHIEARHLDFLPYHYLLVTAGETGWLKYHDVSTGQLVSEL 228 Query: 167 PEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQC 226 + +P + M +S G +W+ + P K+ + Sbjct: 229 RTKAGPTMAMAQNPWNAVMHLGHSNGTVSLWSP--------SMPEPLVKLLSARGPVNSI 280 Query: 227 RFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFS 279 +AT AD++ KIW NF + + S A S Sbjct: 281 AIDRSGYYMATTGADRSMKIWDIRNFKQLHSVESLPTPGTNVSISDTGLLALS 333 Score = 62.5 bits (150), Expect = 2e-10, Method: Composition-based stats. Identities = 28/208 (13%), Positives = 61/208 (29%), Gaps = 14/208 (6%) Query: 9 GSDPVILATAGYDHTVRFWQAHSGICTRTV----QHQDSQVNALEVTPDRSMIAAAGYQH 64 + L G V G + + + A A ++ Sbjct: 119 AKNGTHLLITGRKGHVASMDWRKGQLRAELFLNETCHSA-----TYLQNEQYFAVAQKKY 173 Query: 65 IRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRI 124 +YD + + + + F + T GE + D+ + L + Sbjct: 174 TFIYDHEGTELHRLKQHIEARH----LDFLPYHYLLVTAGETGWLKYHDVSTGQLVSELR 229 Query: 125 FQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASY 184 + P + +P A + +G +G + +W + + S ID Y Sbjct: 230 TKA-GPTMAMAQNPWNAVMHLGHSNGTVSLWSPSMPEPLVKLLSARGPVNSIAIDRSGYY 288 Query: 185 MAAVNSTGNCYVWNLTGGIGDEVTQLIP 212 MA + + +W++ + +P Sbjct: 289 MATTGADRSMKIWDIRNFKQLHSVESLP 316 Score = 60.2 bits (144), Expect = 1e-09, Method: Composition-based stats. Identities = 20/169 (11%), Positives = 54/169 (31%), Gaps = 7/169 (4%) Query: 30 HSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHI-RMYDLNSNNPNPIISYDGVNKNI 88 H G ++ + L+ P ++ AG + +D+++ + Sbjct: 179 HEGTELHRLKQHI-EARHLDFLPYHYLLVTAGETGWLKYHDVSTGQ--LVSELRTKAGPT 235 Query: 89 ASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQ 148 ++ + M+ G + T +W S ++ P+N + + + + Sbjct: 236 MAMAQNPWNAVMHLGHSNGTVSLWS-PSMPEPLVKLLSARGPVNSIAIDRSGYYMATTGA 294 Query: 149 SGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVW 197 ++ IWD++ + T+ I + + +W Sbjct: 295 DRSMKIWDIRNFKQLHSVESLPTPGTNVSISDTGLLALSRGP--HVTLW 341 Score = 52.8 bits (125), Expect = 2e-07, Method: Composition-based stats. Identities = 27/211 (12%), Positives = 65/211 (30%), Gaps = 21/211 (9%) Query: 91 VGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSG 150 + + ++G + G D R L+ + N+ V + Sbjct: 116 IKYAKNGTHLLITGRKGHVASMDWRKGQLRAELFLNETCH--SATYLQNEQYFAVAQKKY 173 Query: 151 AIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQL 210 I+D + +L + + P + TG +++ G Sbjct: 174 TF-IYDHEGTELHRL--KQHIEARHLDFLPYHYLLVTAGETGWLKYHDVSTG-------- 222 Query: 211 IPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSR 270 +++ + +P + ++ ++ T +W S + +L S+R Sbjct: 223 QLVSELRTKAGPTMAMAQNPWNAVMHLGHSNGTVSLWSPSMPEPLVKL--------LSAR 274 Query: 271 GWMWGCAFSGDSQYIVTASSDNLARLWCVET 301 G + A Y+ T +D ++W + Sbjct: 275 GPVNSIAIDRSGYYMATTGADRSMKIWDIRN 305 Score = 35.5 bits (80), Expect = 0.033, Method: Composition-based stats. Identities = 9/54 (16%), Positives = 26/54 (48%), Gaps = 1/54 (1%) Query: 15 LATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMY 68 +AT G D +++ W + +V+ + + ++ D ++A + H+ ++ Sbjct: 289 MATTGADRSMKIWDIRNFKQLHSVESLPTPGTNVSIS-DTGLLALSRGPHVTLW 341 Score = 30.5 bits (67), Expect = 1.1, Method: Composition-based stats. Identities = 21/147 (14%), Positives = 39/147 (26%), Gaps = 20/147 (13%) Query: 176 AHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLL 235 + +++ G+ + G QL + + A + + Sbjct: 116 IKYAKNGTHLLITGRKGHVASMDWRKG------QLRAELFLNETCHSATYLQ---NEQYF 166 Query: 236 ATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLAR 295 A T I+ TEL + F +VTA + Sbjct: 167 AVAQKKYTF-IYDHEG----TELHRLKQHIEARH------LDFLPYHYLLVTAGETGWLK 215 Query: 296 LWCVETGEIKREYGGHQKAVVCLAFND 322 V TG++ E + +A N Sbjct: 216 YHDVSTGQLVSELRTKAGPTMAMAQNP 242 >5MC6-j nrPDB Length = 397 Score = 66.7 bits (161), Expect = 1e-11, Method: Composition-based stats. Identities = 44/328 (13%), Positives = 103/328 (31%), Gaps = 55/328 (16%) Query: 39 QHQDSQVNALEVTPDRSMIAAAGYQHIRMYD---LNSNNP-NPIISYDGVNKNIASVGFH 94 + D+ + ++ + ++ +G +++++D L++ NP + S+ + V Sbjct: 13 KAHDADIFSVS-ACNSFTVSCSGDGYLKVWDNKLLDNENPKDKSYSHFVHKSGLHHVDVL 71 Query: 95 E-------DGRWMYTGGEDCTARIWDLRSRNLQCQRIFQV---------NAPINCVCLHP 138 + + + T + + + + IF+ + Sbjct: 72 QAIERDAFELCLVATTSFSGDLLFYRITREDETKKVIFEKLDLLDSDMKKHSFWALKWGA 131 Query: 139 NQAELIV-----GDQSGAIHIWD------------------LKTDHNEQLIPEPEVSITS 175 + L+ D G +IW L+ + P TS Sbjct: 132 SNDRLLSHRLVATDVKGTTYIWKFHPFADESNSLTLNWSPTLELQGTVESPMTPSQFATS 191 Query: 176 AHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLL 235 I +A + G + L+ + + + ++ +FSP +LL Sbjct: 192 VDISERG-LIATGFNNGTVQISELS--TLRPLYNFESQHSMINNSNSIRSVKFSPQGSLL 248 Query: 236 ATCSADQT---CKIWRTSNFSLMTELSIKSGNPGES-----SRGWMWGCAFSGDSQYIVT 287 A + ++ T + LS+ + + S W+ +F+ + + + Sbjct: 249 AIAHDSNSFGCITLYETEFGERIGSLSVPTHSSQASLGEFAHSSWVMSLSFNDSGETLCS 308 Query: 288 ASSDNLARLWCVETGEIKREYGGHQKAV 315 A D R W V+T E H + Sbjct: 309 AGWDGKLRFWDVKTKERITTLNMHCDDI 336 Score = 50.1 bits (118), Expect = 1e-06, Method: Composition-based stats. Identities = 42/295 (14%), Positives = 88/295 (29%), Gaps = 58/295 (19%) Query: 82 DGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLR-----SRNLQCQRIFQVNAPINCVCL 136 + +I SV + + D ++WD + + + F + ++ V + Sbjct: 13 KAHDADIFSV--SACNSFTVSCSGDGYLKVWDNKLLDNENPKDKSYSHFVHKSGLHHVDV 70 Query: 137 HP-------NQAELIVGDQSGAIHIWDL-KTDHNEQLI-----------PEPEVSITSAH 177 + SG + + + + D +++I + Sbjct: 71 LQAIERDAFELCLVATTSFSGDLLFYRITREDETKKVIFEKLDLLDSDMKKHSFWALKWG 130 Query: 178 IDPD---ASYMAAVNSTGNCYVWNLTGGIGDEVT-------QLIPKTKIPAHT---RYAL 224 D + + A + G Y+W + + L + + + ++A Sbjct: 131 ASNDRLLSHRLVATDVKGTTYIWKFHPFADESNSLTLNWSPTLELQGTVESPMTPSQFAT 190 Query: 225 QCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQY 284 S L+AT + T +I S + +S + ++ + FS Sbjct: 191 SVDISERG-LIATGFNNGTVQISELSTLRPLYNF--ESQHSMINNSNSIRSVKFSPQGSL 247 Query: 285 IVTASSDNL---ARLWCVETGEIKREYG-------------GHQKAVVCLAFNDS 323 + A N L+ E GE H V+ L+FNDS Sbjct: 248 LAIAHDSNSFGCITLYETEFGERIGSLSVPTHSSQASLGEFAHSSWVMSLSFNDS 302 Score = 32.4 bits (72), Expect = 0.30, Method: Composition-based stats. Identities = 8/35 (22%), Positives = 14/35 (40%) Query: 7 TVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQ 41 + L +AG+D +RFW + T+ Sbjct: 298 SFNDSGETLCSAGWDGKLRFWDVKTKERITTLNMH 332 >6IYY-A nrPDB Length = 317 Score = 64.8 bits (156), Expect = 5e-11, Method: Composition-based stats. Identities = 43/269 (15%), Positives = 80/269 (29%), Gaps = 32/269 (11%) Query: 50 VTPDRSMIAAAGYQHIRMYDLNSNNPNPIISY----DGVNKNIASVGFHEDGRWMYTGGE 105 D A R+Y+ + + G + + GG Sbjct: 15 FNQDHGCFACGMENGFRVYNTDPLKEKEKQEFLEGGVGHVEMLFRC-----NYLALVGGG 69 Query: 106 DCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIW-DLKTDHNEQ 164 IWD + + + + V L ++ IV I ++ H Sbjct: 70 KKKVMIWD--DLKKKTVIEIEFSTEVKAVKLRRDR---IVVVLDSMIKVFTFTHNPHQLH 124 Query: 165 LIPEPEVSITSAHIDPDAS---YMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTR 221 + + P+++ TG+ + +L P IPAH Sbjct: 125 VFETCYNPKGLCVLCPNSNNSLLAFPGTHTGHVQLVDLASTEK-------PPVDIPAHEG 177 Query: 222 YALQCRFSPDSTLLATCSADQT-CKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSG 280 + T +AT S T +I+ TS+ L+ EL S ++ F+ Sbjct: 178 VLSCIALNLQGTRIATASEKGTLIRIFDTSSGHLIQELRRG------SQAANIYCINFNQ 231 Query: 281 DSQYIVTASSDNLARLWCVETGEIKREYG 309 D+ I +S ++ E + K + Sbjct: 232 DASLICVSSDHGTVHIFAAEDPKSKWSFS 260 >5TF2-A nrPDB Length = 407 Score = 64.4 bits (155), Expect = 7e-11, Method: Composition-based stats. Identities = 32/193 (16%), Positives = 63/193 (32%), Gaps = 21/193 (10%) Query: 9 GSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMY 68 D +LAT G D VR W+ S + + ++ L + PD ++ ++ Sbjct: 181 NHDNTLLATGGTDGYVRVWKVPSLEKVLEFKAHEGEIEDLALGPDGKLVTVGRDLKASVW 240 Query: 69 D---------LNSNNPNPIIS-YDGVNKNIASVGFHEDGRWMYTGGE---------DCTA 109 N P + Y V G ++T C Sbjct: 241 QKDQLVTQLHWQENGPTFSSTPYRYQACRFGQVPDQPAGLRLFTVQIPHKRLRQPPPCYL 300 Query: 110 RIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPE- 168 WD S L + + ++C+ + + L +G +G++ I+ + + E Sbjct: 301 TAWD-GSNFLPLRTKSCGHEVVSCLDVSESGTFLGLGTVTGSVAIYIAFSLQCLYYVREA 359 Query: 169 PEVSITSAHIDPD 181 + +T P+ Sbjct: 360 HGIVVTDVAFLPE 372 Score = 62.5 bits (150), Expect = 3e-10, Method: Composition-based stats. Identities = 35/223 (15%), Positives = 57/223 (25%), Gaps = 24/223 (10%) Query: 113 DLRSRNLQCQRI-FQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEV 171 +LR NLQ + F + VC + + L G G + +W + + E Sbjct: 156 ELRVENLQAVQTDFSSDPLQKVVCFNHDNTLLATGGTDGYVRVWKVPSLEKVLEFKAHEG 215 Query: 172 SITSAHIDPDASYMAAVNSTGNCYVWN----LTGGIGDEVTQLIPKTKIPAHTRYALQCR 227 I + PD + V VW +T E T Q Sbjct: 216 EIEDLALGPDGK-LVTVGRDLKASVWQKDQLVTQLHWQENGPTFSSTPYRYQACRFGQVP 274 Query: 228 FSPDSTLLATCSADQT---------CKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAF 278 P L T W SNF + + Sbjct: 275 DQPAGLRLFTVQIPHKRLRQPPPCYLTAWDGSNFLPLRT-------KSCGHE-VVSCLDV 326 Query: 279 SGDSQYIVTASSDNLARLWCVETGEI-KREYGGHQKAVVCLAF 320 S ++ + ++ + + H V +AF Sbjct: 327 SESGTFLGLGTVTGSVAIYIAFSLQCLYYVREAHGIVVTDVAF 369 Score = 47.8 bits (112), Expect = 6e-06, Method: Composition-based stats. Identities = 30/214 (14%), Positives = 58/214 (27%), Gaps = 38/214 (17%) Query: 91 VGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSG 150 V F+ D + TGG D R+W + S + I + L P+ +L+ + Sbjct: 178 VCFNHDNTLLATGGTDGYVRVWKVPS-LEKVLEFKAHEGEIEDLALGPDG-KLVTVGRDL 235 Query: 151 AIHIWDLKTDHNEQLIPEPEVSITSAHI------------DPDASYMAAVNSTGN----- 193 +W + E + +S P + V Sbjct: 236 KASVWQKDQLVTQLHWQENGPTFSSTPYRYQACRFGQVPDQPAGLRLFTVQIPHKRLRQP 295 Query: 194 --CYV--WNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRT 249 CY+ W+ + + H S T L + + I+ Sbjct: 296 PPCYLTAWDGSNFLPLRTKSC-------GHE-VVSCLDVSESGTFLGLGTVTGSVAIYIA 347 Query: 250 SNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQ 283 + + + E+ + AF + Sbjct: 348 FSLQCLYYVR-------EAHGIVVTDVAFLPEKG 374 Score = 45.5 bits (106), Expect = 3e-05, Method: Composition-based stats. Identities = 14/63 (22%), Positives = 26/63 (41%) Query: 260 IKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLA 319 +++ SS F+ D+ + T +D R+W V + E E+ H+ + LA Sbjct: 162 LQAVQTDFSSDPLQKVVCFNHDNTLLATGGTDGYVRVWKVPSLEKVLEFKAHEGEIEDLA 221 Query: 320 FND 322 Sbjct: 222 LGP 224 >5LTD-A nrPDB Length = 525 Score = 64.0 bits (154), Expect = 8e-11, Method: Composition-based stats. Identities = 41/250 (16%), Positives = 76/250 (30%), Gaps = 34/250 (13%) Query: 33 ICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVG 92 IC T V +R + + I +YD+N+ I + ++ Sbjct: 112 ICELTFPGAILAVKL-----NRERLVVLLEETIYIYDINNMRLLHTIETPSNPNGLIALS 166 Query: 93 FHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAI 152 + ++ A P V LH N + ++G + Sbjct: 167 PSSENNYLAYPSPQKLA------------------PNPQTEVTLHSNPQTV----RNGDV 204 Query: 153 HIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGN-CYVWNLTGGIGDEVTQLI 211 I+D KT +I S+ + + D +A + G V+++ GI + Sbjct: 205 IIFDAKTLQPTSVIEAHRTSLAAIALSKDGLLLATASDKGTIIRVFSVATGIKLYQFR-- 262 Query: 212 PKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRG 271 + P FSPD+ + SA +T I+R + + + Sbjct: 263 -RGTYPT---KIYSLAFSPDNRFVIASSATETVHIFRLGEEEAANTIKSANKKARLTKAQ 318 Query: 272 WMWGCAFSGD 281 S D Sbjct: 319 VPNPLETSPD 328 Score = 58.6 bits (140), Expect = 4e-09, Method: Composition-based stats. Identities = 33/213 (15%), Positives = 73/213 (34%), Gaps = 43/213 (20%) Query: 109 ARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPE 168 +I + + + C+ F I V L+ + +V I+I+D+ I Sbjct: 101 LKIINTKRQTTICELTFPG--AILAVKLNRER---LVVLLEETIYIYDINNMRLLHTIET 155 Query: 169 PEVS--ITSAHIDPDASYMAAVNS---------------------TGNCYVWNLTGGIGD 205 P + + + +Y+A + G+ +++ Sbjct: 156 PSNPNGLIALSPSSENNYLAYPSPQKLAPNPQTEVTLHSNPQTVRNGDVIIFDAKT---- 211 Query: 206 EVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTC-KIWRTSNFSLMTELSIKSGN 264 L P + I AH S D LLAT S T +++ + + + + Sbjct: 212 ----LQPTSVIEAHRTSLAAIALSKDGLLLATASDKGTIIRVFSVATGIKLYQFRRGT-- 265 Query: 265 PGESSRGWMWGCAFSGDSQYIVTASSDNLARLW 297 ++ AFS D+++++ +S+ ++ Sbjct: 266 ----YPTKIYSLAFSPDNRFVIASSATETVHIF 294 Score = 42.8 bits (99), Expect = 2e-04, Method: Composition-based stats. Identities = 15/67 (22%), Positives = 33/67 (49%), Gaps = 4/67 (5%) Query: 8 VGSDPVILATAGYDHT-VRFWQAHSGICTRTVQHQD--SQVNALEVTPDRSM-IAAAGYQ 63 + D ++LATA T +R + +GI + +++ +L +PD IA++ + Sbjct: 230 LSKDGLLLATASDKGTIIRVFSVATGIKLYQFRRGTYPTKIYSLAFSPDNRFVIASSATE 289 Query: 64 HIRMYDL 70 + ++ L Sbjct: 290 TVHIFRL 296 >3DW8-B nrPDB Length = 447 Score = 63.2 bits (152), Expect = 1e-10, Method: Composition-based stats. Identities = 46/295 (15%), Positives = 109/295 (36%), Gaps = 45/295 (15%) Query: 42 DSQVNALEVTPDRS---MIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGR 98 + ++N + P ++ + + + I+++ ++ + P +G N EDGR Sbjct: 93 EEKINKIRWLPQKNAAQFLLSTNDKTIKLWKISERDKRP----EGYNLK------EEDGR 142 Query: 99 WM----YTGGEDCTARIWDLRSRNLQCQRI-FQVNAPINCVCLHPNQAELIVGDQSGAIH 153 + T R DL + IN + ++ + + D I+ Sbjct: 143 YRDPTTVTTLRVPVFRPMDLMVEASPRRIFANAHTYHINSISINSDYETYLSAD-DLRIN 201 Query: 154 IWDLK-TDHNEQLIPEPEVS-------ITSAHIDPDA-SYMAAVNSTGNCYVWNLTGG-I 203 +W L+ TD + ++ + IT+A P++ + +S G + ++ + Sbjct: 202 LWHLEITDRSFNIVDIKPANMEELTEVITAAEFHPNSCNTFVYSSSKGTIRLCDMRASAL 261 Query: 204 GDEVTQLIPKTKIPAHTRY-------ALQCRFSPDSTLLATCSADQTCKIWRT------- 249 D ++L + + P++ + +FS + T + K+W Sbjct: 262 CDRHSKLFEEPEDPSNRSFFSEIISSISDVKFSHSGRYMMTRDY-LSVKVWDLNMENRPV 320 Query: 250 SNFSLMTELSIKSGNPGESSRGW-MWGCAFSGDSQYIVTASSDNLARLWCVETGE 303 + + L K + E+ + + C ++G ++T S +N R++ T Sbjct: 321 ETYQVHEYLRSKLCSLYENDCIFDKFECCWNGSDSVVMTGSYNNFFRMFDRNTKR 375 Score = 55.5 bits (132), Expect = 3e-08, Method: Composition-based stats. Identities = 38/283 (13%), Positives = 86/283 (30%), Gaps = 66/283 (23%) Query: 7 TVGSDPVILATAGYDHTVRFWQAHSGICTRTV----------QHQDSQVNALEVTPDR-- 54 ++ SD +A D + W I R+ + + A E P+ Sbjct: 184 SINSDYETYLSA-DDLRINLWHLE--ITDRSFNIVDIKPANMEELTEVITAAEFHPNSCN 240 Query: 55 SMIAAAGYQHIRMYDLNSN--------------NPNPIISYDGVNKNIASVGFHEDGRWM 100 + + ++ IR+ D+ ++ +P+ + + +I+ V F GR+M Sbjct: 241 TFVYSSSKGTIRLCDMRASALCDRHSKLFEEPEDPSNRSFFSEIISSISDVKFSHSGRYM 300 Query: 101 YTGGEDC-TARIWDLRSRNLQCQRIFQVNAPIN---------------CVCLHPNQAELI 144 T D + ++WDL N + + C + + + ++ Sbjct: 301 MT--RDYLSVKVWDLNMENRPVETYQVHEYLRSKLCSLYENDCIFDKFECCWNGSDSVVM 358 Query: 145 VGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIG 204 G + ++D T + L E + + P + A + Sbjct: 359 TGSYNNFFRMFDRNTKRDITLEASRENNKPRTVLKP--RKVCASGKRKKDEI-------- 408 Query: 205 DEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIW 247 + L + P ++A + + I+ Sbjct: 409 --------SVDSLDFNKKILHTAWHPKENIIAVATTNN-LYIF 442 >5AMS-A nrPDB Length = 431 Score = 60.9 bits (146), Expect = 6e-10, Method: Composition-based stats. Identities = 34/234 (14%), Positives = 71/234 (30%), Gaps = 15/234 (6%) Query: 81 YDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAP-INCVCLHPN 139 +D ++ ++G H + + TGG D A +W S+ + + Sbjct: 61 FDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSE 120 Query: 140 QAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHI---DPDASYMAA-VNSTGNCY 195 L+ D SG + + + + + + P + A + G Sbjct: 121 GGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDG--S 178 Query: 196 VWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTL---LATCSADQTCKIWRTSNF 252 VW D + + + + + L TCS D T W Sbjct: 179 VWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNCFTG 238 Query: 253 SLMTELSIKSGNPGESSRGWMWGCAFS----GDSQYIVTASSDNLARLWCVETG 302 + +++ ++ G + A G+S + S++ L + G Sbjct: 239 QQLFKIT-QAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNNGLLAVINCNNG 291 Score = 58.2 bits (139), Expect = 5e-09, Method: Composition-based stats. Identities = 44/347 (12%), Positives = 96/347 (27%), Gaps = 79/347 (22%) Query: 38 VQHQDSQVNALEVTPDRSMIAAAGYQHIR-MYDLNSNNPNPIISYDGVNKNIASVGFHED 96 V A+ P+ ++ G ++ ++ +S P + G +++ S F + Sbjct: 61 FDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSE 120 Query: 97 GRWMYTGGEDCTARI---------WDLRSRNLQCQRIF---------------QVNAPIN 132 G ++ T + W L S+ + + I + + Sbjct: 121 GGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVW 180 Query: 133 CVCLHPNQA------------------------------ELIVGDQSGAIHIWDLKTDH- 161 C ++ EL+ I W+ T Sbjct: 181 CYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNCFTGQQ 240 Query: 162 ----NEQLIPEPEVSITSAHIDP------DASYMAAVNSTGNCYVWNLTGGIGDEVTQLI 211 + I E S + P ++ +A ++ G V N G + Sbjct: 241 LFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNNGLLAVINCNNGGAILHLSTV 300 Query: 212 PKTKIPAHT--RYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESS 269 + K +S +L+A ++ TS + + + ++ Sbjct: 301 IELKPEQDELDASIESISWSSKFSLMAIGLVCGEILLYDTSAWRVRHKFVLEDS------ 354 Query: 270 RGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVV 316 + F D + + + + TG+ K GH V+ Sbjct: 355 ---VTKLMFDNDD--LFASCINGKVYQFNARTGQEKFVCVGHNMGVL 396 Score = 50.1 bits (118), Expect = 1e-06, Method: Composition-based stats. Identities = 16/114 (14%), Positives = 37/114 (32%), Gaps = 9/114 (7%) Query: 214 TKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWM 273 T HT P+ L+ T D +W + + K + Sbjct: 59 TYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQ------PPKFAGTLTGYGESV 112 Query: 274 WGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAF---NDSV 324 C+F+ + ++VTA + + G + + + V + + + ++ Sbjct: 113 ISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTI 166 Score = 44.0 bits (102), Expect = 9e-05, Method: Composition-based stats. Identities = 13/151 (8%), Positives = 39/151 (25%), Gaps = 12/151 (7%) Query: 159 TDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPA 218 ++++ + S+ + P+ + ++W + Sbjct: 54 SNNSLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLW------TSHSQPPKFAGTLTG 107 Query: 219 HTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAF 278 + + C F+ + L T + + K + + +W Sbjct: 108 YGESVISCSFTSEGGFLVTADMSGKVLV----HMGQKGGAQWKLASQMQEVEEIVWLKTH 163 Query: 279 SGDSQYIVTASSDNLARLWCVETGEIKREYG 309 ++ ++D WC + E Sbjct: 164 PTIARTFAFGATDGSV--WCYQINEQDGSLE 192 Score = 38.6 bits (88), Expect = 0.003, Method: Composition-based stats. Identities = 27/195 (13%), Positives = 67/195 (34%), Gaps = 27/195 (13%) Query: 1 MNTSPGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQ-----DSQVNALEVTPDRS 55 +NT G + L T D T+ W +G + ++ +L + P+ Sbjct: 210 INTDKGENTLE---LVTCSLDSTIVAWNCFTGQQLFKITQAEIKGLEAPWISLSLAPETL 266 Query: 56 M-----IAAAGYQHIRMYDLNSNNPNPIISY----------DGVNKNIASVGFHEDGRWM 100 + A G + + +N NN I+ D ++ +I S+ + M Sbjct: 267 TKGNSGVVACGSNNGLLAVINCNNGGAILHLSTVIELKPEQDELDASIESISWSSKFSLM 326 Query: 101 YTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTD 160 G ++D + + + F + + + + +L +G ++ ++ +T Sbjct: 327 AIGLVCGEILLYD--TSAWRVRHKFVLEDSVTKLMF--DNDDLFASCINGKVYQFNARTG 382 Query: 161 HNEQLIPEPEVSITS 175 + + + + Sbjct: 383 QEKFVCVGHNMGVLD 397 >6N8P-A nrPDB Length = 979 Score = 57.9 bits (138), Expect = 7e-09, Method: Composition-based stats. Identities = 34/244 (13%), Positives = 73/244 (29%), Gaps = 35/244 (14%) Query: 82 DGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQA 141 G +++G+ R + G +++ + ++ + Q N + + L P Q Sbjct: 18 HGFPHQPSALGYSPSLRILAIGTRSGAIKLY--GAPGVEFMGLHQENNAVTQIHLLPGQC 75 Query: 142 ELIVGDQSGAIHIWDLKTDHNEQLIPEPEVS--------------ITSAHIDPDASYMAA 187 +L+ ++H+W LK + E E IT + Sbjct: 76 QLVTLLDDNSLHLWSLKVKGGASELQEDESFTLRGPPGAAPSATQITVVLPHSSCELLYL 135 Query: 188 VNSTGNCYV---------WNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSP-DSTLLAT 237 +GN +V + T + +L + + + P D + Sbjct: 136 GTESGNVFVVQLPAFRALEDRTISSDAVLQRLPEEARHRRVFEMVEALQEHPRDPNQILI 195 Query: 238 CSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLW 297 + IW ++ S + + D + +V+ SD W Sbjct: 196 GYSRGLVVIWDLQGSRVLYHF---------LSSQQLENIWWQRDGRLLVSCHSDGSYCQW 246 Query: 298 CVET 301 V + Sbjct: 247 PVSS 250 Score = 40.5 bits (93), Expect = 0.001, Method: Composition-based stats. Identities = 41/251 (16%), Positives = 78/251 (31%), Gaps = 44/251 (17%) Query: 39 QHQDSQVNALEVTPDRSMIAAAG-YQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDG 97 Q +AL +P ++A I++Y + N + + Sbjct: 18 HGFPHQPSALGYSPSLRILAIGTRSGAIKLYG---APGVEFMGLHQENNAVTQIHLLPGQ 74 Query: 98 RWMYTGGEDCTARIWDLRSRN----LQCQRIFQVNAP---------INCVCLHPNQAELI 144 + T +D + +W L+ + LQ F + P I V H + L Sbjct: 75 CQLVTLLDDNSLHLWSLKVKGGASELQEDESFTLRGPPGAAPSATQITVVLPHSSCELLY 134 Query: 145 VGDQSGAIHIWDLKTDH--NEQLIPEPEV---------------SITSAHIDP-DASYMA 186 +G +SG + + L ++ I V + + P D + + Sbjct: 135 LGTESGNVFVVQLPAFRALEDRTISSDAVLQRLPEEARHRRVFEMVEALQEHPRDPNQIL 194 Query: 187 AVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKI 246 S G +W+L G + + + D LL +C +D + Sbjct: 195 IGYSRGLVVIWDLQGSRVLYHFLSSQQLE---------NIWWQRDGRLLVSCHSDGSYCQ 245 Query: 247 WRTSNFSLMTE 257 W S+ + E Sbjct: 246 WPVSSEAQQPE 256 Score = 40.1 bits (92), Expect = 0.001, Method: Composition-based stats. Identities = 21/79 (26%), Positives = 33/79 (41%), Gaps = 7/79 (8%) Query: 3 TSPGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQH-QDSQVNALEVTPDRSMIAAAG 61 TS +L T D TVRFW A SG+C R + +V + P+ + A Sbjct: 415 TSLTPAPPQRDLLLTGHEDGTVRFWDA-SGVCLRLLYKLSTVRVFLTDTDPNENFSAQGE 473 Query: 62 Y-----QHIRMYDLNSNNP 75 + + +D S++P Sbjct: 474 DEWPPLRKVGSFDPYSDDP 492 Score = 31.7 bits (70), Expect = 0.43, Method: Composition-based stats. Identities = 11/52 (21%), Positives = 19/52 (36%) Query: 137 HPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAV 188 P + L+ G + G + WD L V + DP+ ++ A Sbjct: 421 PPQRDLLLTGHEDGTVRFWDASGVCLRLLYKLSTVRVFLTDTDPNENFSAQG 472 Score = 31.3 bits (69), Expect = 0.67, Method: Composition-based stats. Identities = 24/139 (17%), Positives = 42/139 (30%), Gaps = 9/139 (6%) Query: 89 ASVGFHEDGR-WMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGD 147 S+ R + TG ED T R WD L+ + PN+ G+ Sbjct: 415 TSLTPAPPQRDLLLTGHEDGTVRFWDASGVCLRLLYKLS-TVRVFLTDTDPNENFSAQGE 473 Query: 148 QSGAIHIWDL--KTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGD 205 W K + +P + I + + Y+A + G V L + Sbjct: 474 DE-----WPPLRKVGSFDPYSDDPRLGIQKIFLCKYSGYLAVAGTAGQVLVLELNDEAAE 528 Query: 206 EVTQLIPKTKIPAHTRYAL 224 + + + + Y Sbjct: 529 QAVEQVEADLLQDQEGYRW 547 Score = 29.0 bits (63), Expect = 2.9, Method: Composition-based stats. Identities = 13/96 (13%), Positives = 27/96 (28%), Gaps = 11/96 (11%) Query: 128 NAPINCVCLHPNQAELIVGDQSGA-IHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMA 186 + ++ + L + + G + A + D L P P P + Sbjct: 379 SHHVSNIPLKLWERIIAAGSRQNAHFSTMEWPIDGGTSLTPAP----------PQRDLLL 428 Query: 187 AVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRY 222 + G W+ +G + +L T Sbjct: 429 TGHEDGTVRFWDASGVCLRLLYKLSTVRVFLTDTDP 464 >5WLC-LV nrPDB Length = 707 Score = 57.1 bits (136), Expect = 9e-09, Method: Composition-based stats. Identities = 35/241 (14%), Positives = 80/241 (33%), Gaps = 25/241 (10%) Query: 69 DLNSNNPNPIISYDGVNKNIASVGFHEDGRW-MYTGGEDCTARIWDLRSRNLQCQRIFQV 127 DL N +I ++ + DG++ M TG ++D + +L+ R Sbjct: 40 DLEYQNRVELIQDFEFSEASNKIKVSRDGQYCMATGTYKPQIHVYDFANLSLKFDR---- 95 Query: 128 NAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNE-----QLIPEPEVSITSAHIDPDA 182 + V ++ D + ++H+ + ++ + S + Sbjct: 96 HTDAENVDFT-----ILSDDWTKSVHLQNDRSIQFQNKGGLHYTTRIPKFGRSLVYNKVN 150 Query: 183 SYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQ 242 + S Y NL G +L T + + LLA + Sbjct: 151 CDLYVGASGNELYRLNLEKGRFLNPFKL--------DTEGVNHVSINEVNGLLAAGTETN 202 Query: 243 TCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETG 302 + W + S +++L ++ N ++ + +F D +S+ + ++ + T Sbjct: 203 VVEFWDPRSRSRVSKLYLE--NNIDNRPFQVTTTSFRNDGLTFACGTSNGYSYIYDLRTS 260 Query: 303 E 303 E Sbjct: 261 E 261 Score = 44.8 bits (104), Expect = 5e-05, Method: Composition-based stats. Identities = 25/181 (13%), Positives = 58/181 (32%), Gaps = 20/181 (11%) Query: 90 SVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAP-INCVCLHPNQAELIVGDQ 148 S+ +++ +Y G ++ L + F+++ +N V ++ L G + Sbjct: 143 SLVYNKVNCDLYVGASGNE--LYRLNLEKGRFLNPFKLDTEGVNHVSINEVNGLLAAGTE 200 Query: 149 SGAIHIWDLKTDHNEQL------IPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGG 202 + + WD ++ I +T+ D A S G Y+++L Sbjct: 201 TNVVEFWDPRSRSRVSKLYLENNIDNRPFQVTTTSFRNDGLTFACGTSNGYSYIYDLRTS 260 Query: 203 IGDEVTQLIPKTKIPAHTRYALQCRFSPD---STLLATCSADQTCKIWRTSNFSLMTELS 259 + K + + + + + TC + KIW + + Sbjct: 261 EPSII-------KDQGYGFDIKKIIWLDNVGTENKIVTCDK-RIAKIWDRLDGKAYASME 312 Query: 260 I 260 Sbjct: 313 P 313 >5AJA-A nrPDB Length = 361 Score = 55.5 bits (132), Expect = 3e-08, Method: Composition-based stats. Identities = 29/214 (13%), Positives = 70/214 (32%), Gaps = 23/214 (10%) Query: 18 AGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAA---GYQHIRMYDLNSNN 74 ++ + SG + +S + LE + D S++ + ++ + S Sbjct: 55 GTCTGQLKLYNVFSGQEEASYNCHNSAITHLEPSRDGSLLLTSATWSQPLSALWGMKSVF 114 Query: 75 PNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRI---FQVNAPI 131 + V F + + G + A I+D+++ N N Sbjct: 115 DMKHSFTEDHY-----VEFSKHSQDRVIGTKGDIAHIYDIQTGNKLLTLFNPDLANNYKR 169 Query: 132 NCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNST 191 NC +P ++ G +WD+++ + ++I+ P+ + Sbjct: 170 NCATFNPTDDLVL---NDGV--LWDVRSAQAIHKFDKFNMNISGV-FHPNGLEVII---- 219 Query: 192 GNCYVWNLTGGIGDEVTQLIPKTKIP-AHTRYAL 224 N +W+L + + ++ HT + Sbjct: 220 -NTEIWDLRTFHLLHTVPALDQCRVVFNHTGTVM 252 Score = 35.9 bits (81), Expect = 0.028, Method: Composition-based stats. Identities = 25/217 (11%), Positives = 56/217 (25%), Gaps = 65/217 (29%) Query: 86 KNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIV 145 F R++ G +++++ S + N+ I + + + L+ Sbjct: 38 SGFTCCAFSARERFLMLGTCTGQLKLYNVFSGQEEASYNC-HNSAITHLEPSRDGSLLLT 96 Query: 146 G----------------------------------DQSGAI-------HIWDLKTDHNEQ 164 Q I HI+D++T + Sbjct: 97 SATWSQPLSALWGMKSVFDMKHSFTEDHYVEFSKHSQDRVIGTKGDIAHIYDIQTGNKLL 156 Query: 165 LIPEPEVS----ITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHT 220 + P+++ A +P + + G +W++ K Sbjct: 157 TLFNPDLANNYKRNCATFNPTDDLVL---NDG--VLWDVRSAQAIH--------KFDKFN 203 Query: 221 RYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTE 257 F P+ + + IW F L+ Sbjct: 204 MNISGV-FHPNGLEVIINTE-----IWDLRTFHLLHT 234 Score = 31.7 bits (70), Expect = 0.44, Method: Composition-based stats. Identities = 11/53 (20%), Positives = 22/53 (41%) Query: 266 GESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCL 318 CAFS ++++ + +L+ V +G+ + Y H A+ L Sbjct: 33 ANEDESGFTCCAFSARERFLMLGTCTGQLKLYNVFSGQEEASYNCHNSAITHL 85 >2I3T-A nrPDB Length = 341 Score = 55.2 bits (131), Expect = 3e-08, Method: Composition-based stats. Identities = 39/293 (13%), Positives = 81/293 (27%), Gaps = 26/293 (8%) Query: 14 ILATAGYDHTVRFWQ----AHSGICTRTVQHQDSQVNALEV--TPDRSMIAAAGYQHIRM 67 +L +D ++ ++ A + ++++ + D + I Sbjct: 25 LLLITSWDGSLTVYKFDIQAKNVDLLQSLR-YKHPLLCCNFIDNTDLQIYVGTVQGEILK 83 Query: 68 YDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRS---RNLQCQRI 124 DL + ++ + N I + + D + + D + D R+ + + + Sbjct: 84 VDLIGSPSFQALTNNEANLGICRICKYGDDKLIA-ASWDGLIEVIDPRNYGDGVIAVKNL 142 Query: 125 FQVNAPINCVCLH--PNQAELIVGDQSGAIHIW--DLKTDHNEQLIPEPEVS-ITSAHID 179 N + N + LIVG + + + L D N + I + Sbjct: 143 NSNNTKVKNKIFTMDTNSSRLIVGMNNSQVQWFRLPLCEDDNGTIEESGLKYQIRDVALL 202 Query: 180 PDASYMAAVNS-TGNCYVW-------NLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPD 231 P A +S G V + K FSP Sbjct: 203 PKEQEGYACSSIDGRVAVEFFDDQGDDYNSSKRFAFRCHRLNLKDTNLAYPVNSIEFSPR 262 Query: 232 STLLATCSADQTCKIWRTSNFSLMTELS--IKSGNPGESSRGWMWGCAFSGDS 282 L T +D W + + + + + A S D+ Sbjct: 263 HKFLYTAGSDGIISCWNLQTRKKIKNFAKFNEDSVVKIACSDNILCLATSDDT 315 Score = 54.8 bits (130), Expect = 6e-08, Method: Composition-based stats. Identities = 44/305 (14%), Positives = 106/305 (34%), Gaps = 23/305 (7%) Query: 39 QHQDSQVNALEVTPDRSMIAAAGYQ---HIRMYDLNSNNPNPIISYDGVNKNIASVGFHE 95 Q ++ +++ P +S++ + + +D+ + N + + S + + Sbjct: 8 QAPKDYISDIKIIPSKSLLLITSWDGSLTVYKFDIQAKNVDLLQSLRYKHPLLCCNFIDN 67 Query: 96 DGRWMYTGGEDCTA-RIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHI 154 +Y G ++ + S + Q + N I C +LI G I + Sbjct: 68 TDLQIYVGTVQGEILKVDLIGSPSFQALTNNEANLGI-CRICKYGDDKLIAASWDGLIEV 126 Query: 155 WDLKT-DHNEQLIPEPEVSITSAH-----IDPDASYMAAVNSTGNCYVWNLTGGIGDEVT 208 D + + + T +D ++S + V + W + ++ Sbjct: 127 IDPRNYGDGVIAVKNLNSNNTKVKNKIFTMDTNSSRLI-VGMNNSQVQW-FRLPLCEDDN 184 Query: 209 QLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKI------WRTSNFSLMTELSIKS 262 I ++ + R + A S D + N S Sbjct: 185 GTIEESGLKYQIRDVALLPKEQEGY--ACSSIDGRVAVEFFDDQGDDYNSSKRFAFRCHR 242 Query: 263 GNPGESSRGW-MWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGG-HQKAVVCLAF 320 N +++ + + FS +++ TA SD + W ++T + + + ++ +VV +A Sbjct: 243 LNLKDTNLAYPVNSIEFSPRHKFLYTAGSDGIISCWNLQTRKKIKNFAKFNEDSVVKIAC 302 Query: 321 NDSVL 325 +D++L Sbjct: 303 SDNIL 307 >3EI3-B nrPDB Length = 383 Score = 54.4 bits (129), Expect = 7e-08, Method: Composition-based stats. Identities = 33/219 (15%), Positives = 60/219 (27%), Gaps = 21/219 (9%) Query: 87 NIASVGFHEDG-RWMYTGGEDCTARIWDLRSRN-LQCQRIFQVNAPINCVCLHP-NQAEL 143 + S+ +H + G + +WD +N + I + + N +L Sbjct: 75 RVTSLEWHPTHPTTVAVGSKGGDIILWDYDVQNKTSFIQGMGPGDAITGMKFNQFNTNQL 134 Query: 144 IVGDQSG--AIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTG 201 V G + + + + +A + TG Sbjct: 135 FVSSIRGATTLRDFSGSVIQVFAKTDSWDYWYCCVDVSVSRQMLATG---------DSTG 185 Query: 202 GIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLL-ATCSADQTCKIWRTSNFSLMTELSI 260 + K H F+P L AT S D T K+W N Sbjct: 186 RLLLLGLDGHEIFKEKLHKAKVTHAEFNPRCDWLMATSSVDATVKLWDLRNIKDKNSYIA 245 Query: 261 KSGNPGESSRGWMWGCAFSG-DSQYIVTASSDNLARLWC 298 + + F+ DS ++T N R++ Sbjct: 246 EM-----PHEKPVNAAYFNPTDSTKLLTTDQRNEIRVYS 279 Score = 54.0 bits (128), Expect = 9e-08, Method: Composition-based stats. Identities = 34/204 (16%), Positives = 70/204 (34%), Gaps = 23/204 (11%) Query: 128 NAPINCVCLHPNQAE-LIVGDQSGAIHIWDLKTDHNEQLIPE--PEVSITSAHID-PDAS 183 + + + HP + VG + G I +WD + I P +IT + + + Sbjct: 73 DRRVTSLEWHPTHPTTVAVGSKGGDIILWDYDVQNKTSFIQGMGPGDAITGMKFNQFNTN 132 Query: 184 YMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQT 243 + + G + + +G + + K + + S +LAT Sbjct: 133 QLFVSSIRGATTLRDFSGSV------IQVFAKTDSWDYWYCCVDVSVSRQMLATG----- 181 Query: 244 CKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYI-VTASSDNLARLWCVETG 302 ++ L+ L + + + F+ ++ T+S D +LW + Sbjct: 182 ----DSTGRLLLLGLDGHEIFKEKLHKAKVTHAEFNPRCDWLMATSSVDATVKLWDLRNI 237 Query: 303 EIKREYGG---HQKAVVCLAFNDS 323 + K Y H+K V FN + Sbjct: 238 KDKNSYIAEMPHEKPVNAAYFNPT 261 Score = 50.9 bits (120), Expect = 8e-07, Method: Composition-based stats. Identities = 33/164 (20%), Positives = 54/164 (32%), Gaps = 22/164 (13%) Query: 13 VILATAGYDHTVRFWQAHSGICTRTVQH---QDSQVNALEVTP--DRSMIAAAGYQHIRM 67 ++AT+ D TV+ W + + + VNA P ++ IR+ Sbjct: 218 WLMATSSVDATVKLWDLRNIKDKNSYIAEMPHEKPVNAAYFNPTDSTKLLTTDQRNEIRV 277 Query: 68 Y-DLNSNNPNPIISYDG----VNKNIASVGFHEDGRWMYTG---------GEDCTARIWD 113 Y + + P+ II + I + +H + G + T I+D Sbjct: 278 YSSYDWSKPDQIIIHPHRQFQHLTPIKA-TWHPMYDLIVAGRYPDDQLLLNDKRTIDIYD 336 Query: 114 LRSRNLQCQRIFQVNAPINCVC-LHPNQAELIVGDQSGAIHIWD 156 S L Q A I + P L G I IW+ Sbjct: 337 ANSGGLVHQLRDPNAAGIISLNKFSPTGDVLASGMGFN-ILIWN 379 >5WLC-LS nrPDB Length = 594 Score = 53.6 bits (127), Expect = 1e-07, Method: Composition-based stats. Identities = 46/339 (13%), Positives = 95/339 (28%), Gaps = 56/339 (16%) Query: 13 VILATAGYDHTVRFW--QAHSGICTRTVQHQDSQVNALEVTPD------RSMIAAAGYQH 64 +L T GYD T+R + + ++ S + +++ A ++ Sbjct: 261 PLLLTGGYDKTLRIYHIDGKTNHLVTSLHLVGSPIQTCTFYTSLSNQNQQNIFTAGRRRY 320 Query: 65 IRMYDL--------NSNNPNPIISYDGVNK--------NIASVGFHEDGR---WMYTGGE 105 + +DL + G +A + + + G Sbjct: 321 MHSWDLSLENLTHSQTAKIEKFSRLYGHESTQRSFENFKVAHLQNSQTNSVHGIVLLQGN 380 Query: 106 DCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQ-----AELIVGDQSGAIHIWDLKTD 160 + I S + C+ P LI + G + +DL + Sbjct: 381 NGWINILHSTSGLWLMGCKIEGVITDFCIDYQPISRGKFRTILIAVNAYGEVWEFDLNKN 440 Query: 161 ---------------HNEQLIPEPEVSITSAHID--PDASYMAAVNSTGNCYVWNLTGGI 203 Q+ + + I ++A + +G +++ + Sbjct: 441 GHVIRRWKDQGGVGITKIQVGGGTTTTCPALQISKIKQNRWLAVGSESGFVNLYDRNNAM 500 Query: 204 GDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSG 263 + P + T +FSPD +L S + K + S+ S Sbjct: 501 TS--STPTPVAALDQLTTTISNLQFSPDGQILCMAS--RAVK--DALRLVHLPSCSVFSN 554 Query: 264 NPGESSR-GWMWGCAFSGDSQYIVTASSDNLARLWCVET 301 P + G + AFS + + RLW + Sbjct: 555 WPTSGTPLGKVTSVAFSPSGGLLAVGNEQGKVRLWKLNH 593 Score = 50.5 bits (119), Expect = 9e-07, Method: Composition-based stats. Identities = 32/240 (13%), Positives = 80/240 (33%), Gaps = 24/240 (10%) Query: 52 PDRSMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARI 111 + ++ +R+ D N+++P+ I S+ FH + TGG D T RI Sbjct: 223 SNSKLLPPKKLDIVRLKDANASHPSH--------SAIQSLSFHPSKPLLLTGGYDKTLRI 274 Query: 112 WDLRSRNLQ-CQRIFQVNAPINCVCL-----HPNQAELIVGDQSGAIHIWDLKTDHNEQL 165 + + + + V +PI + NQ + + +H WDL ++ Sbjct: 275 YHIDGKTNHLVTSLHLVGSPIQTCTFYTSLSNQNQQNIFTAGRRRYMHSWDLSLENLTHS 334 Query: 166 IPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQ 225 +A I+ + ++ + + + + + + + + Sbjct: 335 --------QTAKIEKFSRLYGHESTQRSFENFKVAHLQNSQTNSVHGIVLLQGNNGWIN- 385 Query: 226 CRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYI 285 S L C + + ++ ++ ++ ++ G +W + + I Sbjct: 386 ILHSTSGLWLMGCKIEGVITDF-CIDYQPISRGKFRTILIAVNAYGEVWEFDLNKNGHVI 444 Score = 45.5 bits (106), Expect = 3e-05, Method: Composition-based stats. Identities = 29/231 (12%), Positives = 67/231 (29%), Gaps = 29/231 (12%) Query: 38 VQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLNS-----NNPNPIISYDGVNKNIASVG 92 +Q + +N L T ++ I + ++ I+ + Sbjct: 377 LQGNNGWINILHSTSGLWLMGCKIEGVITDFCIDYQPISRGKFRTILIAVNAYGEVWEFD 436 Query: 93 FHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPN----QAELIVGDQ 148 +++G R W + + C L + L VG + Sbjct: 437 LNKNGH---------VIRRWKDQGGVGITKIQVGGGTTTTCPALQISKIKQNRWLAVGSE 487 Query: 149 SGAIHIWD------LKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGG 202 SG ++++D T + + +I++ PD + + V + Sbjct: 488 SGFVNLYDRNNAMTSSTPTPVAALDQLTTTISNLQFSPDGQILCMASR----AVKDALRL 543 Query: 203 IGDEVTQLIPKTKIPAHT-RYALQCRFSPDSTLLATCSADQTCKIWRTSNF 252 + + FSP LLA + ++W+ +++ Sbjct: 544 VHLPSCSVFSNWPTSGTPLGKVTSVAFSPSGGLLAVGNEQGKVRLWKLNHY 594 Score = 32.4 bits (72), Expect = 0.25, Method: Composition-based stats. Identities = 10/69 (14%), Positives = 21/69 (30%), Gaps = 2/69 (2%) Query: 259 SIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQ--KAVV 316 +K N S + +F ++T D R++ ++ H + Sbjct: 237 RLKDANASHPSHSAIQSLSFHPSKPLLLTGGYDKTLRIYHIDGKTNHLVTSLHLVGSPIQ 296 Query: 317 CLAFNDSVL 325 F S+ Sbjct: 297 TCTFYTSLS 305 >4AV8-A nrPDB Length = 339 Score = 49.4 bits (116), Expect = 2e-06, Method: Composition-based stats. Identities = 36/208 (17%), Positives = 67/208 (32%), Gaps = 17/208 (8%) Query: 93 FHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAI 152 H + + IWD Q +++A + + L E IV Q I Sbjct: 62 LHRTNYIAFVSTKKELLHIWD--DVKKQDITRVKLDAAVKDLFLS---REFIVVSQGDVI 116 Query: 153 HIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIP 212 I+ + I + A+ + ++ N ++T D + Sbjct: 117 SIF-----KFGNPWNKITEDIKFGGVCEFANGLLVYSNEFNLGQIHVTRLQTDAEQVVGK 171 Query: 213 KTKIPAHTRYALQCRFSPDSTLLATCSADQT-CKIWRTSNFSLMTELSIKSGNPGESSRG 271 + AH R + ++ATCS D T ++++T N L+ E R Sbjct: 172 GVLVKAHANPVKMVRLNRKGDMVATCSQDGTLIRVFQTDNGVLVREFRRGL------DRT 225 Query: 272 WMWGCAFSGDSQYIVTASSDNLARLWCV 299 + +S D + S ++ V Sbjct: 226 SIIDMRWSPDGSKLAVVSDKWTLHVFEV 253 Score = 41.3 bits (95), Expect = 6e-04, Method: Composition-based stats. Identities = 40/260 (15%), Positives = 81/260 (31%), Gaps = 33/260 (12%) Query: 54 RSMIAAAGYQH--IRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARI 111 + IA + + ++D + D K++ R + I Sbjct: 65 TNYIAFVSTKKELLHIWDDVKKQDITRVKLDAAVKDLF------LSREFIVVSQGDVISI 118 Query: 112 WDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQS-GAIHIWDLKTDHNEQ-----L 165 + + + + VC N + + + G IH+ L+TD + L Sbjct: 119 FKFGNPWNKITEDIKFGG----VCEFANGLLVYSNEFNLGQIHVTRLQTDAEQVVGKGVL 174 Query: 166 IPEPEVSITSAHIDPDASYMAAVNSTGN-CYVWNLTGGIGDEVTQLIPKTKIPAHTRYAL 224 + + ++ +A + G V+ G+ L+ + + + Sbjct: 175 VKAHANPVKMVRLNRKGDMVATCSQDGTLIRVFQTDNGV------LVREFRRGLDRTSII 228 Query: 225 QCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAF------ 278 R+SPD + LA S T ++ N + +K + + C F Sbjct: 229 DMRWSPDGSKLAVVSDKWTLHVFEVFNDAENKRHVLKDWINIKYFQSEWSICNFKLKVSK 288 Query: 279 -SGDSQYIVTASSDNLARLW 297 S D + I S L +W Sbjct: 289 GSNDCK-IAWISDTGLVIVW 307 Score = 38.2 bits (87), Expect = 0.004, Method: Composition-based stats. Identities = 9/91 (9%), Positives = 32/91 (35%), Gaps = 2/91 (2%) Query: 38 VQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLNSNNPNPIISYDG--VNKNIASVGFHE 95 V+ + V + + M+A + ++N + + +I + + Sbjct: 175 VKAHANPVKMVRLNRKGDMVATCSQDGTLIRVFQTDNGVLVREFRRGLDRTSIIDMRWSP 234 Query: 96 DGRWMYTGGEDCTARIWDLRSRNLQCQRIFQ 126 DG + + T ++++ + + + + Sbjct: 235 DGSKLAVVSDKWTLHVFEVFNDAENKRHVLK 265 Score = 37.8 bits (86), Expect = 0.006, Method: Composition-based stats. Identities = 12/59 (20%), Positives = 26/59 (44%), Gaps = 3/59 (5%) Query: 8 VGSDPVILATAGYDHT-VRFWQAHSGICTRTVQHQ--DSQVNALEVTPDRSMIAAAGYQ 63 + ++AT D T +R +Q +G+ R + + + + +PD S +A + Sbjct: 187 LNRKGDMVATCSQDGTLIRVFQTDNGVLVREFRRGLDRTSIIDMRWSPDGSKLAVVSDK 245 >4FHN-A nrPDB Length = 394 Score = 48.6 bits (114), Expect = 3e-06, Method: Composition-based stats. Identities = 56/300 (18%), Positives = 95/300 (31%), Gaps = 62/300 (20%) Query: 38 VQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLNSNNPNPIISY-----DGVNKNIASVG 92 + D VN+ +P S+ A Q + + + N I + G + + + Sbjct: 88 LHDGDGNVNS---SPVYSLFLACVCQDNTVRLIITKNETIITQHVLGGKSGHHNFVNDID 144 Query: 93 F----HEDGRW----MYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHP-NQAEL 143 D R + + G+DCT IW L + + +++P V P N +L Sbjct: 145 IADVYSADNRLAEQVIASVGDDCTLIIWRL-TDEGPILAGYPLSSPGISVQFRPSNPNQL 203 Query: 144 IVGDQSGAIHIWDLKTD------------HNEQLI---------PEPEVSITSAH----- 177 IVG+++G I I+D + N L+ I S+ Sbjct: 204 IVGERNGNIRIFDWTLNLSAEENSQTELVKNPWLLTLNTLPLVNTCHSSGIASSLANVRW 263 Query: 178 IDPDASYMAAVNSTGNCYVWNL-----TGGIGDEVTQLIPKTKIPAHTR-----YALQCR 227 I D S + A+ +G WNL I D +L PK +P L Sbjct: 264 IGSDGSGILAMCKSGAWLRWNLFANNDYNEISDSTMKLGPKNLLPNVQGISLFPSLLGAC 323 Query: 228 FSPD-STLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIV 286 P AT + L+ S + + + D ++ Sbjct: 324 PHPRYMDYFATAHSQHGL-------IQLINTYEKDSNSIPIQLGMPIVDFCWHQDGSHLA 376 Score = 28.2 bits (61), Expect = 5.0, Method: Composition-based stats. Identities = 23/123 (18%), Positives = 41/123 (33%), Gaps = 18/123 (14%) Query: 184 YMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQC----RFSPDSTL----L 235 ++A V + + +TQ + K H + +S D+ L + Sbjct: 104 FLACVCQDNTVRL--IITKNETIITQHVLGGK-SGHHNFVNDIDIADVYSADNRLAEQVI 160 Query: 236 ATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLAR 295 A+ D T IWR ++ + SS G S +Q IV + R Sbjct: 161 ASVGDDCTLIIWRLTDEGPI------LAGYPLSSPGISVQFRPSNPNQLIV-GERNGNIR 213 Query: 296 LWC 298 ++ Sbjct: 214 IFD 216 Score = 27.8 bits (60), Expect = 6.3, Method: Composition-based stats. Identities = 12/63 (19%), Positives = 24/63 (38%), Gaps = 2/63 (3%) Query: 13 VILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRS--MIAAAGYQHIRMYDL 70 ++A+ G D T+ W+ S +++ P +I +IR++D Sbjct: 158 QVIASVGDDCTLIIWRLTDEGPILAGYPLSSPGISVQFRPSNPNQLIVGERNGNIRIFDW 217 Query: 71 NSN 73 N Sbjct: 218 TLN 220 >5WLC-LH nrPDB Length = 896 Score = 47.1 bits (110), Expect = 1e-05, Method: Composition-based stats. Identities = 38/270 (14%), Positives = 81/270 (30%), Gaps = 28/270 (10%) Query: 36 RTVQHQDSQVNALEVTPDRSMIAAA-GYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFH 94 +++ + V+++ + +A I + L I ++ S+ F Sbjct: 250 QSLSYNTRYVSSMAIDNMGQQLAVGFASGVISIVSLAD---LQIRLLKWHIDSVLSLSFS 306 Query: 95 EDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHP--NQAELIV------G 146 DG ++ +GG + +W L + + Q I+C L P N LI+ Sbjct: 307 HDGSYLLSGGWEKVMSLWQLETNSQQFLPRL-NGIIIDCQVLGPQGNYYSLILQMTENNS 365 Query: 147 DQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDE 206 + + + ++ I P S A N + +L + Sbjct: 366 NSDYQFLLLNASDLTSKLSINGPLPVFNSTIKHIQQPISAMNTKNSN-SITSLNHSKKKQ 424 Query: 207 VTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSG--- 263 +LI + +P + L +I+ + + SG Sbjct: 425 SRKLIKSR----RQDFTTNVEINPINKNLYFPHI-SAVQIFDFYKNEQVNYQYLTSGVNN 479 Query: 264 ------NPGESSRGWMWGCAFSGDSQYIVT 287 + F+ D Q+++T Sbjct: 480 SMGKVRFELNLQDPIITDLKFTKDGQWMIT 509 Score = 41.7 bits (96), Expect = 5e-04, Method: Composition-based stats. Identities = 42/335 (12%), Positives = 100/335 (29%), Gaps = 56/335 (16%) Query: 35 TRTVQHQDSQVNALEVTPDRSMIAAAGYQHI-RMYDLNSNNPNPIISYDGVNKNIASVGF 93 R ++ V +L + D S + + G++ + ++ L +N+ + +G+ I Sbjct: 290 IRLLKWHIDSVLSLSFSHDGSYLLSGGWEKVMSLWQLETNSQQFLPRLNGII--IDCQVL 347 Query: 94 HEDGRW------------------MYTGGEDCTARIWDLRSRNLQCQRIFQV-NAPINCV 134 G + + D T+++ + + PI+ Sbjct: 348 GPQGNYYSLILQMTENNSNSDYQFLLLNASDLTSKL-SINGPLPVFNSTIKHIQQPIS-- 404 Query: 135 CLHPNQAELIVG---DQSGAIH-IWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNS 190 ++ + I + + + + ++ A + Sbjct: 405 AMNTKNSNSITSLNHSKKKQSRKLIKSRRQDFTTNVEINPINKNLYFPHISAVQIFDFYK 464 Query: 191 TGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLAT-----------CS 239 LT G+ + + ++ + + +F+ D + T S Sbjct: 465 NEQVNYQYLTSGVNNSMGKVRFE--LNLQDPIITDLKFTKDGQWMITYEIEYPPNDLLSS 522 Query: 240 AD--QTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSG----DSQYIVTASSDNL 293 D K W ++ L K NP + S +SQ +TA ++ Sbjct: 523 KDLTHILKFWTKNDNETNWNLKTKVINP-HGISVPITKILPSPRSVNNSQGCLTADNNGG 581 Query: 294 ARLWCVETGE---IKREYG----GHQKAVVCLAFN 321 + W ++ E ++ H V LA++ Sbjct: 582 LKFWSFDSHESNWCLKKISLPNFNHFSNSVSLAWS 616 Score = 40.1 bits (92), Expect = 0.001, Method: Composition-based stats. Identities = 32/301 (10%), Positives = 86/301 (28%), Gaps = 39/301 (12%) Query: 20 YDHTVRFWQAHSGICTRTVQHQDSQVNALEVTP---DRSMIAAAGYQHIRMYDLNSNNPN 76 +++ ++ + + C +T++ ++ + + + I I + + Sbjct: 48 FNNQIKVYSVETRQCVKTLKFANNSLLSGIFLQEEENNESIVKILLGDITVPQQEDAHLI 107 Query: 77 PIISYDGVNKNIA---SVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINC 133 + + +G + + + + ++ A ++ N + F+ + Sbjct: 108 TVFTNNGHVIVLNYKGKLVESPK-HFKISLADEKLANVFHSE-GNYRILTTFKDPSQKAH 165 Query: 134 VCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMA-----AV 188 L +D E ++ ++I + +A Sbjct: 166 NSLQ---------SYRLYALTFDDAKKQFEVAHQAEWHNVILSNISSNGKLLAHMCKDVS 216 Query: 189 NSTGNCYVWNLTGGIGDEVTQLIPKTKIPA--------HTRYALQCRFSPDSTLLATCSA 240 ++ D V P I + +TRY LA A Sbjct: 217 TKDHEHKSISVVSLFDDSVNLSFPLGSILSSQTQSLSYNTRYVSSMAIDNMGQQLAVGFA 276 Query: 241 DQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVE 300 I ++ + + + +FS D Y+++ + + LW +E Sbjct: 277 SGVISIVSLADLQI---------RLLKWHIDSVLSLSFSHDGSYLLSGGWEKVMSLWQLE 327 Query: 301 T 301 T Sbjct: 328 T 328 Score = 38.6 bits (88), Expect = 0.004, Method: Composition-based stats. Identities = 21/97 (21%), Positives = 29/97 (29%), Gaps = 7/97 (7%) Query: 197 WNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMT 256 WNL + + +P TKI R +S T + K W + Sbjct: 541 WNLKTKVINPHGISVPITKILPSPRSVN------NSQGCLTADNNGGLKFWSFDSHESNW 594 Query: 257 ELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNL 293 L K P + A+S D I D L Sbjct: 595 CLK-KISLPNFNHFSNSVSLAWSQDGSLIFHGFDDKL 630 Score = 32.8 bits (73), Expect = 0.21, Method: Composition-based stats. Identities = 22/145 (15%), Positives = 51/145 (35%), Gaps = 17/145 (11%) Query: 65 IRMYDLNSNNPNPIISYDG-----VNKNIASVGFHEDGRWMYTGGEDCTARIWDLRS--- 116 ++ + +S+ N + N S+ + +DG ++ G +D +I D + Sbjct: 582 LKFWSFDSHESNWCLKKISLPNFNHFSNSVSLAWSQDGSLIFHGFDDK-LQILDFDTFKK 640 Query: 117 ----RNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVS 172 N + F +++ I V L N LIV ++ ++ +L Sbjct: 641 FESLENTKTVSEFTLDSEIQTVKL-INDTNLIVATRT-TLNAINLLRGQVINSFDLYP-F 697 Query: 173 ITSAHIDPDASYMAAVNST-GNCYV 196 + + + + + GN + Sbjct: 698 VNGVYKNGHMDRLITCDERTGNIAL 722 >3WJ9-A nrPDB Length = 412 Score = 45.9 bits (107), Expect = 2e-05, Method: Composition-based stats. Identities = 46/308 (14%), Positives = 87/308 (28%), Gaps = 51/308 (16%) Query: 21 DHT----VRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLNSNNPN 76 D T ++ W +G + ++ L+ T D S+ A + Y+ + + Sbjct: 99 DGTPKQNMKVWNTETGQLVFSFVQRNQTGWNLQYTCDESLAARLVTNEVHFYETGNMSKG 158 Query: 77 PIISYDGVNKNIASVGFHEDGRWMYTG------GEDCTARIWDLRSRNLQCQRIFQVNAP 130 PI + I+ G + R + + + N + A Sbjct: 159 PIAKLR--VEGISDFALSPGQNHAVAVFIPEKKGAPASVRTYSIPNFNSPLSQKTFFKAD 216 Query: 131 INCVCLHPNQAELIVGDQ---SGAIHIWDLKTDHNEQLIPEP---------EVSITSAHI 178 + L+V Q + + +T+ I E I Sbjct: 217 KVQFKWNALGTSLLVLTQTEVDKSNKNYYGETNLYLLGITGQFDCRVDLDREGPIHDVCW 276 Query: 179 DPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATC 238 + D+ G Y + + + PA FSP+S + Sbjct: 277 NADSKEF------GIVYGYMPAKTAIFDNRANVVSIIPPA---PRNTLIFSPNSRYILLA 327 Query: 239 S---ADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASS----- 290 + I+ +N C FS DSQ+++TA + Sbjct: 328 GFGNLQGSIDIFDAANNMKKIT---------TVEAANCTYCEFSPDSQFLLTAVTSPRLR 378 Query: 291 -DNLARLW 297 DN ++W Sbjct: 379 VDNSIKIW 386 Score = 36.3 bits (82), Expect = 0.017, Method: Composition-based stats. Identities = 21/103 (20%), Positives = 38/103 (36%), Gaps = 20/103 (19%) Query: 215 KIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMW 274 K A + A +SP+ L A +A Q I T + + +T+L + Sbjct: 29 KFEAISEPARNACYSPNGKLFAYATATQVV-INDTESGAKLTQLP----------AANTY 77 Query: 275 GCAFSGDSQYIVT---------ASSDNLARLWCVETGEIKREY 308 FS +Y+ T + ++W ETG++ + Sbjct: 78 ELGFSPLGKYLSTWERPGKEADGTPKQNMKVWNTETGQLVFSF 120 >6CVZ-A nrPDB Length = 351 Score = 45.5 bits (106), Expect = 3e-05, Method: Composition-based stats. Identities = 17/88 (19%), Positives = 30/88 (34%), Gaps = 11/88 (12%) Query: 216 IPAHTRYALQCRFSPD-STLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMW 274 IP H + FS LL + S D T K+ +++ + +W Sbjct: 70 IPMHGKQIRGLAFSSYLRGLLLSASLDNTIKLTSLETNTVVQTYNAG---------RPVW 120 Query: 275 GCAFSGDS-QYIVTASSDNLARLWCVET 301 C + D YI ++ ++ V Sbjct: 121 SCCWCLDEANYIYAGLANGSILVYDVRN 148 Score = 33.2 bits (74), Expect = 0.18, Method: Composition-based stats. Identities = 15/90 (16%), Positives = 32/90 (35%), Gaps = 7/90 (7%) Query: 142 ELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPD-ASYMAAVNSTGNCYVWNLT 200 L+ I + L+T+ Q + S D A+Y+ A + G+ V+++ Sbjct: 89 LLLSASLDNTIKLTSLETNTVVQTYNAGR-PVWSCCWCLDEANYIYAGLANGSILVYDVR 147 Query: 201 GGIGDEVTQLIPKTKIPAHTRYALQCRFSP 230 V +L+ + + + P Sbjct: 148 N-TSSHVQELVAQKA----RCPLVSLSYMP 172 Score = 31.7 bits (70), Expect = 0.51, Method: Composition-based stats. Identities = 14/85 (16%), Positives = 33/85 (38%), Gaps = 4/85 (4%) Query: 14 ILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAG--YQHIRMYDL- 70 +L +A D+T++ + +T + V + D + AG I +YD+ Sbjct: 89 LLLSASLDNTIKLTSLETNTVVQT-YNAGRPVWSCCWCLDEANYIYAGLANGSILVYDVR 147 Query: 71 NSNNPNPIISYDGVNKNIASVGFHE 95 N+++ + + S+ + Sbjct: 148 NTSSHVQELVAQKARCPLVSLSYMP 172 Score = 27.8 bits (60), Expect = 6.1, Method: Composition-based stats. Identities = 15/69 (21%), Positives = 30/69 (43%), Gaps = 2/69 (2%) Query: 253 SLMTELSIKSGNPGESSRGWMWGCAFSGD-SQYIVTASSDNLARLWCVETGEIKREYGGH 311 +++ ++KS + G AFS +++AS DN +L +ET + + Y Sbjct: 57 KMLSTANMKSSQYIPMHGKQIRGLAFSSYLRGLLLSASLDNTIKLTSLETNTVVQTYNA- 115 Query: 312 QKAVVCLAF 320 + V + Sbjct: 116 GRPVWSCCW 124 >2VDU-B nrPDB Length = 450 Score = 44.8 bits (104), Expect = 5e-05, Method: Composition-based stats. Identities = 11/70 (15%), Positives = 25/70 (35%), Gaps = 5/70 (7%) Query: 15 LATAGYDHTVRFWQAHSGICTRT---VQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLN 71 + T+ D ++ +H C + V+++ D +++A G I +D Sbjct: 213 IITSDRDEHIKI--SHYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGGDDKIFAWDWK 270 Query: 72 SNNPNPIISY 81 + Y Sbjct: 271 TGKNLSTFDY 280 Score = 43.6 bits (101), Expect = 1e-04, Method: Composition-based stats. Identities = 27/180 (15%), Positives = 54/180 (30%), Gaps = 19/180 (10%) Query: 137 HPNQAELIVGDQSGAIHIWDL-KTDHNEQLIPEP---EVSITSAHIDPDASYMAAVNSTG 192 + D ++ ++D+ KT N + + + I D + + + G Sbjct: 112 SDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTVIIADKFG 171 Query: 193 NCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDS---TLLATCSADQTCKIWRT 249 + Y ++ ++ TQ I H DS + T D+ KI Sbjct: 172 DVYSIDINSIPEEKFTQ----EPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKI--- 224 Query: 250 SNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYG 309 + G C G +++A D+ W +TG+ + Sbjct: 225 --SHYPQCFIVDKWLFGHKHFVSSICC---GKDYLLLSAGGDDKIFAWDWKTGKNLSTFD 279 Score = 35.9 bits (81), Expect = 0.026, Method: Composition-based stats. Identities = 16/87 (18%), Positives = 34/87 (39%), Gaps = 12/87 (13%) Query: 38 VQHQDSQVNALEVTPDRS----MIAAAGYQHIRMYDLNSNNPNPIISYD---GVNKNIAS 90 + S + + + D +I + +HI++ S+ P I G ++S Sbjct: 191 ILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKI----SHYPQCFIVDKWLFGHKHFVSS 246 Query: 91 VGFHEDGRWMYTGGEDCTARIWDLRSR 117 + +D + GG+D WD ++ Sbjct: 247 ICCGKDYLLLSAGGDDKIF-AWDWKTG 272 >4R40-A nrPDB Length = 411 Score = 44.4 bits (103), Expect = 6e-05, Method: Composition-based stats. Identities = 23/168 (13%), Positives = 57/168 (33%), Gaps = 14/168 (8%) Query: 35 TRTVQHQDSQ--VNALEVTPDRSMIAA----AGYQHIRMYDLNSNNPNPIISYDGVNKNI 88 S + + +PD S IA +G + + L + + S+ N Sbjct: 171 YNQFVVHRSPEPLMSPAWSPDGSKIAYVTFESGKSALVIQTLANGAIRQVASFPRHNG-- 228 Query: 89 ASVGFHEDGRWMYTG-GEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGD 147 + F DG + + + ++ + + Q ++ + P+ L Sbjct: 229 -APAFSPDGTKLAFALSKSGSLNLYVMDLASGQISQVTDGRSNNTEPSWFPDSQNLAYTS 287 Query: 148 QSG---AIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTG 192 G ++ ++ +++ E + + + PD ++ V+S G Sbjct: 288 DQGGRPQVYKVNINGGVPQRITWEGSQNQNA-DVSPDGKFLVLVSSNG 334 Score = 30.9 bits (68), Expect = 0.77, Method: Composition-based stats. Identities = 24/128 (18%), Positives = 40/128 (31%), Gaps = 15/128 (11%) Query: 160 DHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAH 219 +N+ ++ + S PD S +A V G V Q + I Sbjct: 170 GYNQFVVHRSPEPLMSPAWSPDGSKIAYVT---------FESGKSALVIQTLANGAIRQV 220 Query: 220 TRYAL---QCRFSPDSTLLA---TCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWM 273 + FSPD T LA + S + ++ + +S N S Sbjct: 221 ASFPRHNGAPAFSPDGTKLAFALSKSGSLNLYVMDLASGQISQVTDGRSNNTEPSWFPDS 280 Query: 274 WGCAFSGD 281 A++ D Sbjct: 281 QNLAYTSD 288 >5K1H-B nrPDB Length = 576 Score = 43.2 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 29/229 (12%), Positives = 57/229 (24%), Gaps = 51/229 (22%) Query: 9 GSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMY 68 D + D T FW + + +P + +A + I ++ Sbjct: 133 CRDQYSVIFESGDRTSIFWN-DVKDPVSIEERARWTETYVRWSPKGTYLATFHQRGIALW 191 Query: 69 DLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVN 128 S+ G + + F R++ T Sbjct: 192 GGEKFKQIQRFSHQG----VQLIDFSPCERYLVT-------------------------- 221 Query: 129 APINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSA-HIDPDASYMAA 187 P + D AI IWD+ T H ++ + D + A Sbjct: 222 -------FSP---LMDTQDDPQAIIIWDILTGHKKRGFHCESSAHWPIFKWSHDGKFFAR 271 Query: 188 VNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLA 236 + ++ L+ K + +SP ++A Sbjct: 272 MTLD-TLSIYETPS------MGLLDKKSLK--ISGIKDFSWSPGGNIIA 311 Score = 30.9 bits (68), Expect = 0.78, Method: Composition-based stats. Identities = 20/117 (17%), Positives = 39/117 (33%), Gaps = 12/117 (10%) Query: 44 QVNALEVTPDRSMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTG 103 Q N + +P + AG + + + + + + + V + GR++ T Sbjct: 441 QANTIFWSPQGQFVVLAGLRSMNGALAFVDTSDCTVMNIAEHYMASDVEWDPTGRYVVTS 500 Query: 104 GE------DCTARIWDLRSRNLQCQRIFQVNAPINC-VCLHPNQAELIVGDQSGAIH 153 D +W + R LQ + N C + P L+ +Q I Sbjct: 501 VSWWSHKVDNAYWLWTFQGRLLQ-----KNNKDRFCQLLWRPRPPTLLSQEQIKQIK 552 >4NOX-A nrPDB Length = 746 Score = 41.7 bits (96), Expect = 4e-04, Method: Composition-based stats. Identities = 21/152 (13%), Positives = 43/152 (28%), Gaps = 15/152 (9%) Query: 149 SGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVT 208 W+ + D E ++ + T P +Y+ +V++ G +W Sbjct: 177 DTVGVFWNNEKDQPENIVDRQHWTETFVQWSPLGTYLTSVHAQG-VQLWGGASWSRLRRF 235 Query: 209 QLIPKTKIPAHTRYALQCRFS------PD-STLLATCSADQTCK-IWRTSNFSLMTELS- 259 + +S PD + T D IW + + Sbjct: 236 PHPFVNLVAFSPGEKYLVTWSNRPIQIPDSGHPVLTLDDDGKNYIIWDIETARPLRSFAQ 295 Query: 260 ----IKSGNPGESSRGWMWGC-AFSGDSQYIV 286 + P + + W +S D +Y+ Sbjct: 296 QDIHPEEHGPKKGPPKFPWPVFKWSADDKYVA 327 Score = 40.9 bits (94), Expect = 7e-04, Method: Composition-based stats. Identities = 21/140 (15%), Positives = 42/140 (30%), Gaps = 27/140 (19%) Query: 35 TRTVQHQDSQVNALEVTPDRSMIAAA-------GYQHIRMYDLNSNNPNPIISY------ 81 RT++ ++ NA+ +P + A D + P Sbjct: 516 LRTLEKKNH--NAIYWSPKGRFVVIATVHNTQSSDLEFWDLDFDGEKPENEKDLAACLQL 573 Query: 82 --DGVNKNIASVGFHEDGRWMYT--GGEDCTA----RIWDLRSRNLQCQRIFQVNAPINC 133 G + I V + GR++ T T ++D + L+ + I + Sbjct: 574 MGTGDHYGITDVEWDPSGRYVATWASAWKHTMENGYHLYDFKGELLREEHIEKFKQW--- 630 Query: 134 VCLHPNQAELIVGDQSGAIH 153 P L+ ++ I Sbjct: 631 -QWRPRPPTLLTKEEQKQIR 649 Score = 32.0 bits (71), Expect = 0.39, Method: Composition-based stats. Identities = 28/212 (13%), Positives = 60/212 (28%), Gaps = 36/212 (16%) Query: 87 NIASVG--FHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELI 144 +++ V + +G ++ D ++ ++ L+ R+ + P+ V Sbjct: 410 SVSDVKMHWQSEGTYLCV-KVDRHSKSKKSQATTLEIFRVKEKGVPVEVVDTI------- 461 Query: 145 VGDQSGAIHI-WDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGI 203 + I+ W+ K D + V T+ S+ GN G Sbjct: 462 ---KDTVINFAWEPKGDRFVIITTPEPVGATAVPPKTSVSFFCPELKKGN------QVGS 512 Query: 204 GDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQT----CKIWRT----SNFSLM 255 + L K H +SP + + T + W Sbjct: 513 FKHLRTLEKK----NHN----AIYWSPKGRFVVIATVHNTQSSDLEFWDLDFDGEKPENE 564 Query: 256 TELSIKSGNPGESSRGWMWGCAFSGDSQYIVT 287 +L+ G + + +Y+ T Sbjct: 565 KDLAACLQLMGTGDHYGITDVEWDPSGRYVAT 596 Score = 30.9 bits (68), Expect = 0.84, Method: Composition-based stats. Identities = 22/167 (13%), Positives = 52/167 (31%), Gaps = 31/167 (18%) Query: 5 PGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQH 64 P G D ++ D FW V Q ++ +P + + + Q Sbjct: 163 PADRGRDQFVMYRG--DTVGVFWNNEKDQPENIVDRQHWTETFVQWSPLGTYLTSVHAQG 220 Query: 65 IRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRI 124 ++++ S + + + V F +++ T + + +I Sbjct: 221 VQLWGGASWSRLRRFPHP----FVNLVAFSPGEKYLVT--------------WSNRPIQI 262 Query: 125 FQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEV 171 P+ + L + I IWD++T + + ++ Sbjct: 263 PDSGHPV--LTLDDDGKNYI---------IWDIETARPLRSFAQQDI 298 Score = 29.7 bits (65), Expect = 1.6, Method: Composition-based stats. Identities = 26/145 (17%), Positives = 42/145 (28%), Gaps = 22/145 (15%) Query: 117 RNLQCQRIFQVNAPINCVCLHPNQAELIVGD----QSGAIHIWDLKTD-----------H 161 + + R + N + P +++ QS + WDL D Sbjct: 511 GSFKHLRTLEKKNH-NAIYWSPKGRFVVIATVHNTQSSDLEFWDLDFDGEKPENEKDLAA 569 Query: 162 NEQLI-PEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHT 220 QL+ IT DP Y+A S W T G + + H Sbjct: 570 CLQLMGTGDHYGITDVEWDPSGRYVATWAS-----AWKHTMENGYHLYDFKGELLREEHI 624 Query: 221 RYALQCRFSPDSTLLATCSADQTCK 245 Q ++ P L T + + Sbjct: 625 EKFKQWQWRPRPPTLLTKEEQKQIR 649 >5WLC-LL nrPDB Length = 643 Score = 40.9 bits (94), Expect = 7e-04, Method: Composition-based stats. Identities = 28/218 (12%), Positives = 70/218 (32%), Gaps = 22/218 (10%) Query: 38 VQHQDSQVNALEV----TPDRSMIAAA-GYQHIRMYDLNSNNPNPIISYDGVNKNIASVG 92 ++ +V L+ + D I I +Y + +N + G + I + Sbjct: 53 LEDSKLKVTCLKWVNLASSDTVAIILGMNNGEIWLYSVLANEVTYKFT-TGNSYEIKDID 111 Query: 93 FHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQ---AELIVGDQS 149 + W + +DL L +N + + P A+L+V Sbjct: 112 LMGNQLWCIDSSD--AFYQFDLLQFKLLQHFRINNCVQLNKLTIVPAGDSVAQLLVAS-- 167 Query: 150 GAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQ 209 +I + D++ P +++ + + +++ V+++ G+ V Sbjct: 168 HSISLIDIEEKKVVMTFPGHVSPVSTLQVITNEFFISGAEGDRFLNVYDIHSGMTKCVLV 227 Query: 210 LIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIW 247 + S + +A + D + +I+ Sbjct: 228 A---------ESDIKELSHSGQADSIAVTTEDGSLEIF 256 Score = 30.5 bits (67), Expect = 0.90, Method: Composition-based stats. Identities = 16/183 (8%), Positives = 50/183 (27%), Gaps = 21/183 (11%) Query: 131 INCVCL----HPNQAELIVGDQSGAIHIWDLKTDH-NEQLIPEPEVSITSAHIDPDASYM 185 + C+ + +I+G +G I ++ + + + I + + + Sbjct: 60 VTCLKWVNLASSDTVAIILGMNNGEIWLYSVLANEVTYKFTTGNSYEIKDIDLMGNQLWC 119 Query: 186 AAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCK 245 + Y ++L + ++ ++ T + L S + Sbjct: 120 IDSSD--AFYQFDLLQFKLLQHFRINNCVQLNKLTIVPAGDSVA----QLLVAS--HSIS 171 Query: 246 IWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIK 305 + ++ + + +I A D ++ + +G K Sbjct: 172 LIDIEEKKVVMTFPGHV--------SPVSTLQVITNEFFISGAEGDRFLNVYDIHSGMTK 223 Query: 306 REY 308 Sbjct: 224 CVL 226 Score = 28.2 bits (61), Expect = 4.6, Method: Composition-based stats. Identities = 21/168 (12%), Positives = 49/168 (29%), Gaps = 21/168 (12%) Query: 156 DLKTDHNEQLIPEPEVSITSAHI----DPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLI 211 D + N + + ++ +T D + + G +++++ Sbjct: 43 DTVWNENFLYLEDSKLKVTCLKWVNLASSDTVAIILGMNNGEIWLYSVLANEVTYKFT-- 100 Query: 212 PKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRG 271 ++ + S+D + F L+ I + Sbjct: 101 -----TGNSYEIKDIDLMGNQLW-CIDSSDAF-YQFDLLQFKLLQHFRI-----NNCVQL 148 Query: 272 WMWGCAFSGDS-QYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCL 318 +GDS ++ AS + L +E ++ + GH V L Sbjct: 149 NKLTIVPAGDSVAQLLVAS--HSISLIDIEEKKVVMTFPGHVSPVSTL 194 >4IMM-A nrPDB Length = 399 Score = 39.7 bits (91), Expect = 0.002, Method: Composition-based stats. Identities = 40/304 (13%), Positives = 84/304 (27%), Gaps = 38/304 (12%) Query: 8 VGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRM 67 + + + A +G V+ S + ++ D+ ++ I Sbjct: 117 IDDQGSVAVIGTRSGKLIALDARTGAARWVVELASSSLAPALISGDKVIVITNS-GTIFG 175 Query: 68 YDLNSNNPNPIISYDGVNKNIASVG--FHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIF 125 D+NS + N ++ + D R + GG D D + R Sbjct: 176 LDINSGATVWQYATQVPNTSVRGMAKPLALDARTVLIGGADGRIHALDTMTGAPVWTRRV 235 Query: 126 Q---VNAPINCVCLHPNQAELIV------GDQSGAIHIWDLKTDHNEQLIPEPEVSITSA 176 + I+ + + +V SG + +D+ T + S Sbjct: 236 GLAMGSGEIDQLR-DIDGTPTVVDHYLYAASYSGQLAGFDMTTGRT--MFVSELSSTKKL 292 Query: 177 HIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLA 236 DA + ++ G+ +N G + K T T +A Sbjct: 293 TTLADA--VIGSSTDGDVVAFNRMTGEKLWENHDL---KYRGLTNPVT------IGTYIA 341 Query: 237 TCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARL 296 AD I +++ + K + + S+D + + Sbjct: 342 VGDADGVVHILNHQ-GQIISRANTKGALTNLTVIN-----------NRLYAQSADGVVTV 389 Query: 297 WCVE 300 W + Sbjct: 390 WQFK 393 >5OLJ-A nrPDB Length = 723 Score = 38.6 bits (88), Expect = 0.004, Method: Composition-based stats. Identities = 36/252 (14%), Positives = 78/252 (30%), Gaps = 29/252 (11%) Query: 67 MYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCT-ARIWDLRSRNLQCQRIF 125 +YD + N + + F DGR + ++ + +D + Sbjct: 122 VYDYDVRR-NLVKPLSEHVGKVMIPTFSPDGRMVAFVRDNNIFIKKFDFDTEVQVTT--- 177 Query: 126 QVNAPINCVCLHPNQ---------AELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSA 176 + IN V L+ A + +++D E +PE + + Sbjct: 178 --DGQINSVLNGATDWVYEEEFGVTNLMSWSADNAFLAF-VRSD--ESAVPEYRMPMYED 232 Query: 177 HIDPDA---SYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDST 233 + P+ Y A +L + I A Y + F+ ++ Sbjct: 233 KLYPEDYTYKYPKAGEKNSTV---SLHLYNVADRNTKSVSLPIDA-DGYIPRIAFTDNAD 288 Query: 234 LLATCSAD---QTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASS 290 LA + + K++ SL+ +L ++ N W+ F+ + + Sbjct: 289 ELAVMTLNRLQNDFKMYYVHPKSLVPKLILQDMNKRYVDSDWIQALKFTAGGGFAYVSEK 348 Query: 291 DNLARLWCVETG 302 D A ++ + Sbjct: 349 DGFAHIYLYDNK 360 >5GRS-A nrPDB Length = 396 Score = 37.1 bits (84), Expect = 0.010, Method: Composition-based stats. Identities = 12/100 (12%), Positives = 34/100 (34%), Gaps = 7/100 (7%) Query: 104 GEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNE 163 D T R + I + + N + +WDL+ + Sbjct: 10 STDTTLHEEKFRIEPVPV----HHQLDILKIAVSENYKTFASVGLDRCLVVWDLRQWCTK 65 Query: 164 QLIPEPE--VSITSAHIDPDASYMAAVNSTGNCYVWNLTG 201 ++ + + ++ + +DP +Y++ + ++ N+ Sbjct: 66 LVLSKEQMPRTLKAIALDPQGNYVSLFSKD-TLFILNVES 104 Score = 33.2 bits (74), Expect = 0.14, Method: Composition-based stats. Identities = 11/74 (14%), Positives = 25/74 (33%), Gaps = 3/74 (4%) Query: 83 GVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPIN--CVCLHPNQ 140 +I + E+ + + G D +WDLR + + + P + L P Sbjct: 28 HHQLDILKIAVSENYKTFASVGLDRCLVVWDLRQWCTKLV-LSKEQMPRTLKAIALDPQG 86 Query: 141 AELIVGDQSGAIHI 154 + + + + Sbjct: 87 NYVSLFSKDTLFIL 100 Score = 33.2 bits (74), Expect = 0.16, Method: Composition-based stats. Identities = 39/254 (15%), Positives = 89/254 (35%), Gaps = 24/254 (9%) Query: 40 HQDSQVNALEVTPDRSMIAAAGYQHI-RMYDLNSNNPNPIISYDGVNKNIASVGFHEDGR 98 H + + V+ + A+ G ++DL ++S + + + + ++ G Sbjct: 28 HHQLDILKIAVSENYKTFASVGLDRCLVVWDLRQWCTKLVLSKEQMPRTLKAIALDPQGN 87 Query: 99 WMYTGGEDCTARIWDLRSRNLQCQRIF--QVNAPINCVCLHP--------NQAELIVGDQ 148 ++ +D + ++ S +L Q + + N+ +N V P EL+V + Sbjct: 88 YVSLFSKDTLFIL-NVESPSLMLQHSYHCKPNSKLN-VFWMPGTHKDDEWKNFELVVVES 145 Query: 149 SGAIHIWDLKTDHN-------EQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTG 201 SG I ++ L + E+ + + + + P A+ +A + +G V++ G Sbjct: 146 SGEIQVFSLTIEIEGADIALVEKFQLSSPIIKSISIVSPTANRIACLTESGEVTVYSKKG 205 Query: 202 GIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIK 261 + K + + + D LA D + N L+ ++ Sbjct: 206 PVWSPKILSQNKNYLTETKKDIYGIAMA-DILFLA---RDSGVDMIDLKNDELLHSFTLP 261 Query: 262 SGNPGESSRGWMWG 275 S G Sbjct: 262 PIKVNTFSVGVSNS 275 >4YHC-A nrPDB Length = 468 Score = 37.1 bits (84), Expect = 0.012, Method: Composition-based stats. Identities = 12/100 (12%), Positives = 35/100 (35%), Gaps = 7/100 (7%) Query: 104 GEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNE 163 D T R + I + + N ++ +WDL+ + Sbjct: 10 STDTTLHEEKFRIEPVPV----HHQLDILKIAVSENYKTFASVGLDRSLVVWDLRQWCTK 65 Query: 164 QLIPEPE--VSITSAHIDPDASYMAAVNSTGNCYVWNLTG 201 ++ + + ++ + +DP +Y++ + ++ N+ Sbjct: 66 LVLSKEQMPRTLKAIALDPQGNYVSLFSKD-TLFILNVES 104 Score = 35.1 bits (79), Expect = 0.040, Method: Composition-based stats. Identities = 39/254 (15%), Positives = 91/254 (35%), Gaps = 24/254 (9%) Query: 40 HQDSQVNALEVTPDRSMIAAAG-YQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGR 98 H + + V+ + A+ G + + ++DL ++S + + + + ++ G Sbjct: 28 HHQLDILKIAVSENYKTFASVGLDRSLVVWDLRQWCTKLVLSKEQMPRTLKAIALDPQGN 87 Query: 99 WMYTGGEDCTARIWDLRSRNLQCQRIFQV--NAPINCVCLHP--------NQAELIVGDQ 148 ++ +D + ++ S +L Q + N+ +N V P EL+V + Sbjct: 88 YVSLFSKDTLFIL-NVESPSLMLQHSYHSKPNSKLN-VFWMPGTHKDDEWKNFELVVVES 145 Query: 149 SGAIHIWDLKTDHN-------EQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTG 201 SG I ++ L + E+ + + + + P A+ +A++ +G V++ G Sbjct: 146 SGEIQVFSLTIEIEGADIALVEKFQLSSPIIKSISIVSPTANRIASLTESGEVTVYSKKG 205 Query: 202 GIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIK 261 + K + + + D LA D + N L+ ++ Sbjct: 206 PVWSPKILSQNKNYLTETKKDIYGIAMA-DILFLA---RDSGVDMIDLKNDELLHSFTLP 261 Query: 262 SGNPGESSRGWMWG 275 S G Sbjct: 262 PIKVNTFSVGVSNS 275 >5BPW-A nrPDB Length = 843 Score = 36.7 bits (83), Expect = 0.015, Method: Composition-based stats. Identities = 20/93 (21%), Positives = 39/93 (41%), Gaps = 7/93 (7%) Query: 48 LEVTPDRSMIAAAGY-QHIRMYDLNSNNPNPIISY---DGVNKNIASVGFHEDGRWMYTG 103 L +P R +IA A + ++ L S + + S+ + K + + + DG+ + Sbjct: 26 LVWSPKRDLIALANTAGEVLLHRLASFH--RVWSFPPNENTGKEVTCLAWRPDGKLLAFA 83 Query: 104 GEDCTARIWDLRSRNLQCQRIFQVNAPINCVCL 136 D T +I + F V AP++C+ Sbjct: 84 LAD-TKKIVLCDVEKPESLHSFSVEAPVSCMHW 115 Score = 35.1 bits (79), Expect = 0.038, Method: Composition-based stats. Identities = 17/90 (18%), Positives = 34/90 (37%), Gaps = 6/90 (6%) Query: 221 RYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSG 280 + + +SP L+A + + R ++F + S P E++ + A+ Sbjct: 21 QEIIFLVWSPKRDLIALANTAGEVLLHRLASFH-----RVWSFPPNENTGKEVTCLAWRP 75 Query: 281 DSQYIVTASSD-NLARLWCVETGEIKREYG 309 D + + A +D L VE E + Sbjct: 76 DGKLLAFALADTKKIVLCDVEKPESLHSFS 105 >5BPT-A nrPDB Length = 741 Score = 34.4 bits (77), Expect = 0.064, Method: Composition-based stats. Identities = 20/99 (20%), Positives = 35/99 (35%), Gaps = 19/99 (19%) Query: 48 LEVTPDRSMIAA---AGY-------QHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDG 97 L +P R +IA AG R++ L N K + + + DG Sbjct: 19 LAWSPKRDLIALVNKAGEVLLHRLANIQRVWSLPPNENT--------GKEVTCLAWRPDG 70 Query: 98 RWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCL 136 + + G D T ++ + F + PI+C+ Sbjct: 71 KILAFGLAD-TKKVILCDVEKPESLHSFSLETPISCMQW 108 Score = 34.0 bits (76), Expect = 0.089, Method: Composition-based stats. Identities = 16/90 (17%), Positives = 31/90 (34%), Gaps = 6/90 (6%) Query: 221 RYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSG 280 + +SP L+A + + R +N + L P E++ + A+ Sbjct: 14 HEIIFLAWSPKRDLIALVNKAGEVLLHRLANIQRVWSLP-----PNENTGKEVTCLAWRP 68 Query: 281 DSQYIVTASSD-NLARLWCVETGEIKREYG 309 D + + +D L VE E + Sbjct: 69 DGKILAFGLADTKKVILCDVEKPESLHSFS 98 >5CWW-B nrPDB Length = 595 Score = 33.2 bits (74), Expect = 0.16, Method: Composition-based stats. Identities = 16/96 (16%), Positives = 31/96 (32%), Gaps = 13/96 (13%) Query: 220 TRYALQCRFSPDSTLLATCSADQTCKIWRTSNFS---------LMTELSIKSGNPGESSR 270 Q SP+ LA ++ T I + S + +SR Sbjct: 114 ADDIRQLVMSPNQDFLAVLTS-HTVHICILPDSSHLHIQDTTPFKPKFWTLGPTTHVTSR 172 Query: 271 GWMWGCAFSG---DSQYIVTASSDNLARLWCVETGE 303 + + + +VT + D + R+W + T + Sbjct: 173 SAVVSAVWHPLGVNGHALVTVTEDAIVRVWELSTAD 208 Score = 32.8 bits (73), Expect = 0.22, Method: Composition-based stats. Identities = 30/188 (15%), Positives = 61/188 (32%), Gaps = 31/188 (16%) Query: 63 QHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTA---RIWDLRSRNL 119 IR ++ N + + +I D ++ +D T + W L Sbjct: 115 DDIRQLVMSPNQ-DFLAVLTSHTVHIC---ILPDSSHLHI--QDTTPFKPKFWTLG---- 164 Query: 120 QCQRIFQVNAPINCVCLHP---NQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSA 176 + +A ++ V HP N L+ + + +W+L T P ++I Sbjct: 165 PTTHVTSRSAVVSAV-WHPLGVNGHALVTVTEDAIVRVWELSTAD-RWTFDAPTLAI-DL 221 Query: 177 HIDPDASYM---AAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDST 233 DA+Y+ V+++ ++ + P ++P + Sbjct: 222 KKLADATYLDQDFGVSTSATNKGFSPDAFDMEVAAACFPTRDSGG---------WAPMTL 272 Query: 234 LLATCSAD 241 LA S D Sbjct: 273 WLAMTSGD 280 >1C5K-A nrPDB Length = 439 Score = 32.8 bits (73), Expect = 0.20, Method: Composition-based stats. Identities = 25/130 (19%), Positives = 43/130 (33%), Gaps = 19/130 (14%) Query: 160 DHNEQLIPEPEVSITSAHIDPDASYMAAV---NSTGNCYVWNLTGGIGDEVTQLIPKTKI 216 +N+ ++ + S PD S +A V + + L G +V Sbjct: 190 GYNQFVVHRSPQPLMSPAWSPDGSKLAYVTFESGRSALVIQTLANGAVRQV------ASF 243 Query: 217 PAHTRYALQCRFSPDSTLLA-----TCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRG 271 P H FSPD + LA T S + + ++ + +S N + Sbjct: 244 PRHNGAP---AFSPDGSKLAFALSKTGSLN--LYVMDLASGQIRQVTDGRSNNTEPTWFP 298 Query: 272 WMWGCAFSGD 281 AF+ D Sbjct: 299 DSQNLAFTSD 308 >2EEP-A nrPDB Length = 706 Score = 32.4 bits (72), Expect = 0.30, Method: Composition-based stats. Identities = 16/135 (11%), Positives = 45/135 (33%), Gaps = 13/135 (9%) Query: 64 HIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYT-----GGEDCTARIWDLRSRN 118 + +Y L + + + + K + ++ + D +Y +C +D + Sbjct: 236 TVGIYHLATGKTVYLQTGEPKEKFLTNLSWSPDENILYVAEVNRAQNECKVNAYDAETGR 295 Query: 119 LQCQRIFQVN----APINCVCLHP-NQAELIVGD-QSG--AIHIWDLKTDHNEQLIPEPE 170 + + P++ + P + + I + G ++++D Q+ Sbjct: 296 FVRTLFVETDKHYVEPLHPLTFLPGSNNQFIWQSRRDGWNHLYLYDTTGRLIRQVTKGEW 355 Query: 171 VSITSAHIDPDASYM 185 A DP + + Sbjct: 356 EVTNFAGFDPKGTRL 370 >3US8-A nrPDB Length = 427 Score = 31.3 bits (69), Expect = 0.58, Method: Composition-based stats. Identities = 21/141 (14%), Positives = 39/141 (27%), Gaps = 12/141 (8%) Query: 101 YTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTD 160 ++GG + +D ++ + F + V + P+ + G + T Sbjct: 282 WSGGYVWACKNYDGDVQSDIVAQGFGSLGLMTSVLMTPDGKTVEAEAAHGTV------TR 335 Query: 161 HNEQLIPEPEVSITSAH--IDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPA 218 H Q E S S GN + + + ++ T Sbjct: 336 HYRQHQKGEETSTNSIASIFAWTRGLAHRAKLDGNAEL----AKFSETLERVCVDTVESG 391 Query: 219 HTRYALQCRFSPDSTLLATCS 239 L PD L+T Sbjct: 392 FMTKDLALLIGPDQPWLSTTG 412 >3MWP-A nrPDB Length = 577 Score = 31.3 bits (69), Expect = 0.66, Method: Composition-based stats. Identities = 17/86 (19%), Positives = 32/86 (37%), Gaps = 10/86 (11%) Query: 43 SQVNALEVTPDRSMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKN---------IASVGF 93 S + +T D +I AA + ++ + + P Y G + + +G Sbjct: 95 SILRVGTLTSDDLLILAADLEKLKSKVIRTERPLSAGVYMGNLSSQQLDQRRALLNMIGM 154 Query: 94 HEDGRWMYTGGEDCTARIWDLRSRNL 119 G G D R+WD+++ L Sbjct: 155 S-GGNQGARAGRDGVVRVWDVKNAEL 179 >6IGB-A nrPDB Length = 364 Score = 30.9 bits (68), Expect = 0.81, Method: Composition-based stats. Identities = 18/134 (13%), Positives = 39/134 (29%), Gaps = 14/134 (10%) Query: 168 EPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVT-----QLIPKTKIPAHTRY 222 + + PD + VN G + G +L +++ + Sbjct: 38 AHTSNPSYLTFAPDQRTLFVVNENGRGGKGDTVGRATSYRFDPISGRLQQISQVQTLADH 97 Query: 223 ALQCRFSPDSTLLATCSA----DQTCKIWRT-SNFSLMTELSIKSGNPGESSR----GWM 273 S D L + + + + ++ SL + ++S + G + Sbjct: 98 PTYSSLSHDGRYLFVANYSVQPEGSVAVLPVRADGSLAPVVQVESHQASKVHPRQVSGHV 157 Query: 274 WGCAFSGDSQYIVT 287 S D QY+ Sbjct: 158 HSVVSSPDGQYLFA 171 >2H47-A nrPDB Length = 390 Score = 30.1 bits (66), Expect = 1.3, Method: Composition-based stats. Identities = 11/72 (15%), Positives = 28/72 (38%) Query: 26 FWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLNSNNPNPIISYDGVN 85 W + R + ++ + R+++ ++ +YD++ P + + +G Sbjct: 317 IWVMDTKTKQRVARIPGRDALSMTIDQQRNLMLTLDGGNVNVYDISQPEPKLLRTIEGAA 376 Query: 86 KNIASVGFHEDG 97 + V FH G Sbjct: 377 EASLQVQFHPVG 388 >5WLC-LK nrPDB Length = 575 Score = 30.1 bits (66), Expect = 1.4, Method: Composition-based stats. Identities = 25/182 (13%), Positives = 51/182 (28%), Gaps = 10/182 (5%) Query: 70 LNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIF---- 125 + S+N I++ K I E W+ D + L+ N + + F Sbjct: 113 VYSSNGKDIVNIIKNKKEILGADTDESDIWILDS--DKVVK--KLQYNNSKPLKTFTLVD 168 Query: 126 -QVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASY 184 + + ++ LH N L+ ++I D + D Y Sbjct: 169 GKDDEIVHFQILHQNGTLLVCIITKQMVYIVDPSKRRPSTKYSFEISDAVACEFSSDGKY 228 Query: 185 MAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTC 244 + N+ ++L + + + + AD+ C Sbjct: 229 LLIANNE-ELIAYDLKEDSKLIQSWPVQVKTLKTLDDLIMALTTDGKINNYKIGEADKVC 287 Query: 245 KI 246 I Sbjct: 288 SI 289 >2EIG-A nrPDB Length = 234 Score = 29.7 bits (65), Expect = 1.8, Method: Composition-based stats. Identities = 25/157 (15%), Positives = 45/157 (28%), Gaps = 21/157 (13%) Query: 24 VRFWQAHSGICTRTVQHQDSQVNALEVTP--DRSMIAAAGYQHIRMYDLNSNNPNPIISY 81 V W + +G + V+ ++ P D + A + PN Y Sbjct: 49 VPIWDSATGNVASFITSFSFIVSNVQRYPPTDGVVFFLAPWGT-------EIPPNSQGGY 101 Query: 82 DGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCV-CLHPNQ 140 G+ + D +WD +S R + +N + L Sbjct: 102 LGITDS------SNSQNQFVAVEFDSHPNVWDPKS-----LRSSHIGIDVNSIMSLKAVN 150 Query: 141 AELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAH 177 + G A I+D T ++ IT+ Sbjct: 151 WNRVSGSLEKATIIYDSDTKILTVVMTHQNGQITTIS 187 >5TXC-A nrPDB Length = 705 Score = 29.3 bits (64), Expect = 2.2, Method: Composition-based stats. Identities = 21/147 (14%), Positives = 39/147 (26%), Gaps = 19/147 (12%) Query: 8 VGSDPVILATAGYDHTVRFWQAHSGICT-------RTVQHQDSQVNALEVTPDRSMIAAA 60 S+ L + D +Q V+ D +A++V + Sbjct: 53 SASETTPLLSLSPDGRYVAFQVRQADPVTNLNVFRMVVKATDGATDAIDVDVGGEYLFW- 111 Query: 61 GYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGED-CTARIWDLRSRNL 119 I + N P G N I + G + +D R+W + Sbjct: 112 ---TIPSWGYARNAP------SGANLTIQP-RWSPSGTHLAYLRQDQGRVRVWRASVKGE 161 Query: 120 QCQRIFQVNAPINCVCLHPNQAELIVG 146 + + I V + + G Sbjct: 162 GASPVIEDAYDIEDVQWLDDNTLIYSG 188 >1AOM-A nrPDB Length = 567 Score = 29.3 bits (64), Expect = 2.6, Method: Composition-based stats. Identities = 28/238 (11%), Positives = 67/238 (28%), Gaps = 34/238 (14%) Query: 46 NALEVTP-DRSMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASV----------GFH 94 + V P DR + ++ + + I DG I +V Sbjct: 146 WKVHVAPEDRPTQQMNDWDLENLFSVTLRDAGQIALIDGSTYEIKTVLDTGYAVHISRLS 205 Query: 95 EDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLH-----PNQAELIVGDQS 149 GR+++ G D + DL + ++ + + ++ + Sbjct: 206 ASGRYLFVIGRDGKVNMIDLWMKEPTTVAEIKIGSEARSIETSKMEGWEDKYAIAGAYWP 265 Query: 150 GAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDAS------------YMAAVNSTGNCYVW 197 I D +T +++ ++ P+ ++ V TG + Sbjct: 266 PQYVIMDGETLEPKKIQSTRGMTYDEQEYHPEPRVAAILASHYRPEFIVNVKETGKILLV 325 Query: 198 NLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLM 255 + T + T++ + + H + +A + T L+ Sbjct: 326 DYTDLNNLKTTEISAERFL--HDGGLDG----SHRYFITAANARNKLVVIDTKEGKLV 377 >5SUM-A nrPDB Length = 468 Score = 29.0 bits (63), Expect = 2.9, Method: Composition-based stats. Identities = 7/31 (22%), Positives = 16/31 (51%), Gaps = 1/31 (3%) Query: 281 DSQYIVTASSDNLARLWCVET-GEIKREYGG 310 D +Y++ D R++ ++T + + Y G Sbjct: 376 DGKYLLQGGLDRYVRIFDIKTNKMLVKVYVG 406 >2QC5-A nrPDB Length = 300 Score = 29.0 bits (63), Expect = 3.0, Method: Composition-based stats. Identities = 14/130 (10%), Positives = 31/130 (23%), Gaps = 11/130 (8%) Query: 134 VCLHPNQAELIVGDQSGAIHIWDLKTDHNEQL----------IPEPEVSITSAHIDPDAS 183 + + + I + G + K + L +P P+ + + Sbjct: 15 LSIPDSGPYGITSSEDGKVWFTQHKANKISSLDQSGRIKEFEVPTPDAKVMCLIVSSLGD 74 Query: 184 YMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSP-DSTLLATCSADQ 242 N + GG + F+ + + +AD Sbjct: 75 IWFTENGANKIGKLSKKGGFTEYPLPQPDSGPYGITEGLNGDIWFTQLNGDRIGKLTADG 134 Query: 243 TCKIWRTSNF 252 T + N Sbjct: 135 TIYEYDLPNK 144 >6BN7-A nrPDB Length = 864 Score = 28.2 bits (61), Expect = 4.5, Method: Composition-based stats. Identities = 9/43 (20%), Positives = 17/43 (39%) Query: 18 AGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAA 60 A + TVR ++ + RT + + + AL + I Sbjct: 606 ASINSTVRLYEWTTEKELRTECNHYNNIMALYLKTKGDFILVG 648 >5JN2-A nrPDB Length = 525 Score = 28.2 bits (61), Expect = 5.0, Method: Composition-based stats. Identities = 15/76 (19%), Positives = 24/76 (31%), Gaps = 4/76 (5%) Query: 124 IFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDL-KTDHNEQLIPEPEVSITSAHIDPDA 182 + I L P L + I I D + H E + T+ +I P+ Sbjct: 181 TYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPE- 239 Query: 183 SYMAAVNSTGNCYVWN 198 + C VW+ Sbjct: 240 --VLHGTYDEKCDVWS 253 >3MA6-A nrPDB Length = 298 Score = 28.2 bits (61), Expect = 5.0, Method: Composition-based stats. Identities = 15/76 (19%), Positives = 24/76 (31%), Gaps = 4/76 (5%) Query: 124 IFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDL-KTDHNEQLIPEPEVSITSAHIDPDA 182 + I L P L + I I D + H E + T+ +I P+ Sbjct: 146 TYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPE- 204 Query: 183 SYMAAVNSTGNCYVWN 198 + C VW+ Sbjct: 205 --VLHGTYDEKCDVWS 218 >2QT9-A nrPDB Length = 766 Score = 27.8 bits (60), Expect = 6.2, Method: Composition-based stats. Identities = 21/135 (15%), Positives = 37/135 (27%), Gaps = 24/135 (17%) Query: 162 NEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTR 221 + L + + S D Y+ N V+N G + + + Sbjct: 46 TDYLKNTYRLKLYSLRWISDHEYLY--KQENNILVFNAEYGNS---SVFLENSTFDEFGH 100 Query: 222 YALQCRFSPDSTLLA-------------TCSADQTCKIWRTSNFSLMTELSIKSGNPGES 268 SPD + T S D I+ + L+TE I + + Sbjct: 101 SINDYSISPDGQFILLEYNYVKQWRHSYTASYD----IYDLNKRQLITEERIPNNTQWVT 156 Query: 269 SRGWMWGCA--FSGD 281 A ++ D Sbjct: 157 WSPVGHKLAYVWNND 171 Score = 27.8 bits (60), Expect = 7.6, Method: Composition-based stats. Identities = 14/95 (14%), Positives = 33/95 (34%), Gaps = 14/95 (14%) Query: 20 YDHTVRFWQAHSGICT-----RTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMY------ 68 ++ + + A G + T +N ++PD I Y +++ + Sbjct: 72 QENNILVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILL-EYNYVKQWRHSYTA 130 Query: 69 --DLNSNNPNPIISYDGVNKNIASVGFHEDGRWMY 101 D+ N +I+ + + N V + G + Sbjct: 131 SYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLA 165 Score = 27.4 bits (59), Expect = 8.6, Method: Composition-based stats. Identities = 27/221 (12%), Positives = 60/221 (27%), Gaps = 49/221 (22%) Query: 56 MIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNI--ASVGFHEDGRWMYTGGEDCTARIWD 113 ++ ++ + Y + S+ + D ++Y ++ +++ Sbjct: 27 LLNKGTDDATA----DTRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYK--QENNILVFN 80 Query: 114 LRSRNLQC----QRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIW--------DLKTDH 161 N + IN + P+ +++ + + W D+ + Sbjct: 81 AEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILL--EYNYVKQWRHSYTASYDIYDLN 138 Query: 162 NEQLIPEPEVSITS--AHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAH 219 QLI E + + P +A YVWN + E + Sbjct: 139 KRQLITEERIPNNTQWVTWSPVGHKLA--------YVWNNDIYVKIEPNLPSYRITWTGK 190 Query: 220 TRYA-----------------LQCRFSPDSTLLATCSADQT 243 +SP+ T LA + T Sbjct: 191 EDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDT 231 >1HJS-A nrPDB Length = 332 Score = 27.8 bits (60), Expect = 6.2, Method: Composition-based stats. Identities = 18/93 (19%), Positives = 28/93 (30%), Gaps = 6/93 (6%) Query: 197 WNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLAT-----CSADQTCKIWRTSN 251 W+ T ++ + + + F P + AT S D K W Sbjct: 183 WDWGTQNW-WYTNVLKQGTLELSDFDMMGVSFYPFYSSSATLSALKSSLDNMAKTWNKEI 241 Query: 252 FSLMTELSIKSGNPGESSRGWMWGCAFSGDSQY 284 + T I NP S + FS + Q Sbjct: 242 AVVETNWPISCPNPRYSFPSDVKNIPFSPEGQT 274 >1NQH-A nrPDB Length = 594 Score = 27.8 bits (60), Expect = 6.8, Method: Composition-based stats. Identities = 18/103 (17%), Positives = 35/103 (33%), Gaps = 10/103 (9%) Query: 4 SPGTVGSDPVILATAGYDHTVRFWQAHSGICTRT-VQHQDSQVNALEVTP-DRSMIAAAG 61 SPG+ D L + +D +R ++G ++ + S P ++A Sbjct: 234 SPGSPLLDTRKLYSQSWDAGLR----YNGELIKSQLITSYSHSKDYNYDPHYGRYDSSAT 289 Query: 62 YQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGG 104 ++ Y + N + G A V + + TG Sbjct: 290 LDEMKQYTVQWANNVIV----GHGSIGAGVDWQKQTTTPGTGY 328 >3R3L-A nrPDB Length = 582 Score = 27.8 bits (60), Expect = 7.3, Method: Composition-based stats. Identities = 14/91 (15%), Positives = 26/91 (28%), Gaps = 2/91 (2%) Query: 217 PAHTRYALQC-RFSPDSTLLATCSADQ-TCKIWRTSNFSLMTELSIKSGNPGESSRGWMW 274 + L+ S D L ++ K+ RT + R + Sbjct: 82 STQQKSVLRVGTLSSDDLLTLAADLEKLKSKVTRTERPLSSGVYMGNLSSQQLDQRRALL 141 Query: 275 GCAFSGDSQYIVTASSDNLARLWCVETGEIK 305 + A D + R+W V+ E+ Sbjct: 142 NLIGMTNGSQGSQAGRDGVVRVWDVKNAELL 172 >2FTW-A nrPDB Length = 521 Score = 27.4 bits (59), Expect = 7.7, Method: Composition-based stats. Identities = 12/74 (16%), Positives = 23/74 (31%), Gaps = 8/74 (10%) Query: 20 YDHTVRFWQ--AHSGI---CTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLNSNN 74 D W+ ++G C + + P + I I ++D N + Sbjct: 352 EDRMSIVWENGVNTGKLTWCQFVRATSSERARIFNIYPRKGRIDVGCDGDIVIWDPNQSK 411 Query: 75 PNPIISYDGVNKNI 88 IS D + + Sbjct: 412 ---TISKDTHHHAV 422 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.310 0.126 0.337 Lambda K H 0.267 0.0389 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 12,053,426 Number of Sequences: 36641 Number of extensions: 416877 Number of successful extensions: 5933 Number of sequences better than 10.0: 179 Number of HSP's better than 10.0 without gapping: 225 Number of HSP's successfully gapped in prelim test: 75 Number of HSP's that attempted gapping in prelim test: 1196 Number of HSP's gapped (non-prelim): 1462 length of query: 326 length of database: 10,336,785 effective HSP length: 97 effective length of query: 229 effective length of database: 6,782,608 effective search space: 1553217232 effective search space used: 1553217232 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.3 bits) S2: 59 (27.4 bits)