BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q9BV79 (373 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 2VCY-A nrPDB 698 0.0 5LB9-A nrPDB 219 2e-57 1YB5-A nrPDB 75 6e-14 4A27-A nrPDB 74 8e-14 3SLK-A nrPDB 72 6e-13 1QOR-A nrPDB 70 2e-12 1WLY-A nrPDB 64 9e-11 3JYN-A nrPDB 64 1e-10 1U3W-A nrPDB 61 7e-10 4CPD-A nrPDB 61 7e-10 4EYE-A nrPDB 61 8e-10 4Z6K-A nrPDB 59 2e-09 1HSZ-A nrPDB 59 4e-09 5K1S-A nrPDB 59 4e-09 3TQH-A nrPDB 57 1e-08 1HSO-A nrPDB 57 2e-08 2OBY-A nrPDB 55 3e-08 3UOG-A nrPDB 55 5e-08 2Y05-A nrPDB 55 6e-08 3QWB-A nrPDB 54 8e-08 3PII-A nrPDB 54 8e-08 4IDE-A nrPDB 54 1e-07 4UEJ-A nrPDB 53 2e-07 3MEQ-A nrPDB 53 2e-07 1H2B-A nrPDB 53 3e-07 1MC5-A nrPDB 52 3e-07 1V3V-A nrPDB 52 4e-07 4RVS-A nrPDB 52 4e-07 5A3V-A nrPDB 51 8e-07 1EE2-A nrPDB 51 8e-07 4J6F-A nrPDB 51 9e-07 5YAT-A nrPDB 50 2e-06 3COS-A nrPDB 50 2e-06 1D1T-A nrPDB 49 3e-06 1P0F-A nrPDB 49 4e-06 1YQX-A nrPDB 48 7e-06 4DVJ-A nrPDB 48 9e-06 6N7L-A nrPDB 47 1e-05 2VN8-A nrPDB 47 2e-05 3FBG-A nrPDB 47 2e-05 2J3K-A nrPDB 47 2e-05 1E3E-A nrPDB 46 2e-05 1LLU-A nrPDB 46 3e-05 5ENV-A nrPDB 45 4e-05 2EER-A nrPDB 45 5e-05 2WEK-A nrPDB 45 6e-05 5FI5-A nrPDB 45 6e-05 3S2F-A nrPDB 44 1e-04 1O89-A nrPDB 44 1e-04 4RQU-A nrPDB 43 2e-04 5VKT-A nrPDB 43 2e-04 4DLA-A nrPDB 43 2e-04 3HZZ-A nrPDB 41 9e-04 1CDO-A nrPDB 41 0.001 4OH1-A nrPDB 39 0.002 5TNX-A nrPDB 39 0.003 1F8F-A nrPDB 39 0.004 5Z0C-A nrPDB 38 0.006 1R37-A nrPDB 37 0.013 4GKV-A nrPDB 37 0.015 4JJI-A nrPDB 37 0.015 3B70-A nrPDB 37 0.016 1PL8-A nrPDB 36 0.022 3TWO-A nrPDB 36 0.033 1KEV-A nrPDB 35 0.038 5GXF-A nrPDB 35 0.047 1UUF-A nrPDB 34 0.090 3QE3-A nrPDB 33 0.14 3FPL-A nrPDB 33 0.17 4AEC-A nrPDB 33 0.29 1Q1N-A nrPDB 32 0.32 4OAQ-A nrPDB 32 0.35 4Y1B-A nrPDB 32 0.36 3FSR-A nrPDB 32 0.39 1YKF-A nrPDB 32 0.41 3FPC-A nrPDB 32 0.42 5H83-A nrPDB 32 0.63 2DFV-A nrPDB 31 0.73 1E3J-A nrPDB 31 0.80 3GFB-A nrPDB 31 0.84 2OUI-A nrPDB 31 0.85 5YLN-A nrPDB 31 1.0 3V8B-A nrPDB 30 1.3 5VM2-A nrPDB 30 2.0 3DWF-A nrPDB 30 2.1 2EFY-A nrPDB 30 2.2 2YXE-A nrPDB 30 2.5 6FG0-A nrPDB 29 2.6 6C49-A nrPDB 29 2.8 1EVJ-A nrPDB 28 6.3 >2VCY-A nrPDB Length = 344 Score = 698 bits (1802), Expect = 0.0, Method: Compositional matrix adjust. Identities = 342/343 (99%), Positives = 342/343 (99%) Query: 31 ASSYSASAEPARVRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMI 90 ASSYSASAEPARVRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMI Sbjct: 2 ASSYSASAEPARVRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMI 61 Query: 91 QGNYGFLPELPAVGGNEGVAQVVAVGSNVTGLKPGDWVIPANAGLGTWRTEAVFSEEALI 150 QGNYG LPELPAVGGNEGVAQVVAVGSNVTGLKPGDWVIPANAGLGTWRTEAVFSEEALI Sbjct: 62 QGNYGLLPELPAVGGNEGVAQVVAVGSNVTGLKPGDWVIPANAGLGTWRTEAVFSEEALI 121 Query: 151 QVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLR 210 QVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLR Sbjct: 122 QVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLR 181 Query: 211 TINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFFKDMPQPRLALNCVGGKSST 270 TINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFFKDMPQPRLALNCVGGKSST Sbjct: 182 TINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFFKDMPQPRLALNCVGGKSST 241 Query: 271 ELLRQLARGGTMVTYGGMAKQPVVASVSLLIFKDLKLRGFWLSQWKKDHSPDQFKELILT 330 ELLRQLARGGTMVTYGGMAKQPVVASVSLLIFKDLKLRGFWLSQWKKDHSPDQFKELILT Sbjct: 242 ELLRQLARGGTMVTYGGMAKQPVVASVSLLIFKDLKLRGFWLSQWKKDHSPDQFKELILT 301 Query: 331 LCDLIRRGQLTAPACSQVPLQDYQSALEASMKPFISSKQILTM 373 LCDLIRRGQLTAPACSQVPLQDYQSALEASMKPFISSKQILTM Sbjct: 302 LCDLIRRGQLTAPACSQVPLQDYQSALEASMKPFISSKQILTM 344 >5LB9-A nrPDB Length = 385 Score = 219 bits (558), Expect = 2e-57, Method: Compositional matrix adjust. Identities = 131/330 (39%), Positives = 190/330 (57%), Gaps = 37/330 (11%) Query: 44 RALVYGHHGDPAKVVELKNLELA--AVRGSDVRVKMLAAPINPSDINMIQGNY------- 94 +A++Y HG+P V+ ++ E+ + ++V VK L +P+NPSDIN IQG Y Sbjct: 26 QAVLYTQHGEPKDVLFTQSFEIDDDNLAPNEVIVKTLGSPVNPSDINQIQGVYPSKPAKT 85 Query: 95 -GFLPELPAV-GGNEGVAQVVAVGSNVTGLKPGDWVIPANAGLGTWRTEAVFSEEALIQV 152 GF PA GNEG+ +V+ VGSNV+ L+ GDWVIP++ GTWRT A+ +++ I++ Sbjct: 86 TGFGTTEPAAPCGNEGLFEVIKVGSNVSSLEAGDWVIPSHVNFGTWRTHALGNDDDFIKL 145 Query: 153 PS-----------DIPLQSAATLGVNPCTAYRMLMDFEQLQPG-DSVIQNASNSGVGQAV 200 P+ + + AT+ VNP AY ML + +L PG D IQN S VG+ Sbjct: 146 PNPAQSKANGKPNGLTINQGATISVNPLVAYLMLTHYVKLTPGKDWFIQNGGTSAVGKYA 205 Query: 201 IQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRR----PEMKNFFKDMP- 255 QI L +I+V+RDRP++ ++ LK LGA VITE++ P +K + K Sbjct: 206 SQIGKLLNFNSISVIRDRPNLDEVVASLKELGATQVITEDQNNSREFGPTIKEWIKQSGG 265 Query: 256 QPRLALNCVGGKSSTELLRQLARGGTMVTYGGMAKQPVVASVSLLIFKDLKLRGFWLSQW 315 + +LALNCVGGKSST + R+L G M+TYGGM+ QPV SL IFK+ GFW+++ Sbjct: 266 EAKLALNCVGGKSSTGIARKLNNNGLMLTYGGMSFQPVTIPTSLYIFKNFTSAGFWVTEL 325 Query: 316 KKDHSPDQFKELILTLCDLI----RRGQLT 341 K++ KEL + + I G+LT Sbjct: 326 LKNN-----KELKTSTLNQIIAWYEEGKLT 350 >1YB5-A nrPDB Length = 351 Score = 74.7 bits (182), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 42/140 (30%), Positives = 74/140 (52%) Query: 73 VRVKMLAAPINPSDINMIQGNYGFLPELPAVGGNEGVAQVVAVGSNVTGLKPGDWVIPAN 132 V +K+ A +NP + + G Y P LP G++ + AVG N + K GD V ++ Sbjct: 60 VLIKVHACGVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIEAVGDNASAFKKGDRVFTSS 119 Query: 133 AGLGTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNAS 192 G + A+ ++ + ++P + + A +G+ TAYR L+ ++ G+SV+ + + Sbjct: 120 TISGGYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGA 179 Query: 193 NSGVGQAVIQIAAALGLRTI 212 + GVG A QIA A GL+ + Sbjct: 180 SGGVGLAACQIARAYGLKIL 199 >4A27-A nrPDB Length = 349 Score = 74.3 bits (181), Expect = 8e-14, Method: Compositional matrix adjust. Identities = 57/215 (26%), Positives = 101/215 (46%), Gaps = 8/215 (3%) Query: 72 DVRVKMLAAPINPSDINMIQGNYGFLPELPAVGGNEGVAQVVAVGSNVTGLKPGDWVIPA 131 ++++++ A +N D+ + QGN P+ P V G E V A+G +V G + GD V+ A Sbjct: 32 ELKIRVKACGLNFIDLMVRQGNIDNPPKTPLVPGFECSGIVEALGDSVKGYEIGDRVM-A 90 Query: 132 NAGLGTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNA 191 W E + ++P D+ AA +N TAY ML + L+ G SV+ ++ Sbjct: 91 FVNYNAWAEVVCTPVEFVYKIPDDMSFSEAAAFPMNFVTAYVMLFEVANLREGMSVLVHS 150 Query: 192 SNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFF 251 + GVGQAV Q+ + + T+ + + D + L + +E++R + Sbjct: 151 AGGGVGQAVAQLCSTVPNVTVFGTASTFKHEAIKDSVTHLFDRNADYVQEVKRISAEGV- 209 Query: 252 KDMPQPRLALNCVGGKSSTELLRQLARGGTMVTYG 286 + L+C+ G ++ + L L GT + YG Sbjct: 210 ------DIVLDCLCGDNTGKGLSLLKPLGTYILYG 238 >3SLK-A nrPDB Length = 795 Score = 71.6 bits (174), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 67/223 (30%), Positives = 102/223 (45%), Gaps = 28/223 (12%) Query: 72 DVRVKMLAAPINPSDINMIQGNYGFLPELPAVGGNEGVAQVVAVGSNVTGLKPGDWV--- 128 +VR+ M AA +N D + G Y + L G+EG VV G VTGL PGD V Sbjct: 240 EVRIAMRAAGVNFRDALIALGMYPGVASL----GSEGAGVVVETGPGVTGLAPGDRVMGM 295 Query: 129 IPANAGLGTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVI 188 IP G AV + ++P+ AA++ + TAY L+D L+PG+S++ Sbjct: 296 IPKAFG-----PLAVADHRMVTRIPAGWSFARAASVPIVFLTAYYALVDLAGLRPGESLL 350 Query: 189 QNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKS--LGAEHVITEEELRRPE 246 +++ GVG A IQ+A LG + D+ ++ L EH+ + R + Sbjct: 351 VHSAAGGVGMAAIQLARHLGAEVYATASE--------DKWQAVELSREHLASS---RTCD 399 Query: 247 MKNFFKDMPQPR---LALNCVGGKSSTELLRQLARGGTMVTYG 286 + F R + LN + G+ + LR L RGG + G Sbjct: 400 FEQQFLGATGGRGVDVVLNSLAGEFADASLRMLPRGGRFLELG 442 >1QOR-A nrPDB Length = 327 Score = 70.1 bits (170), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 88/322 (27%), Positives = 138/322 (42%), Gaps = 27/322 (8%) Query: 48 YGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPELPAVGGNE 107 + HG P +V++ A ++++V+ A IN D + G Y P LP+ G E Sbjct: 7 FHKHGGP-EVLQAVEFTPADPAENEIQVENKAIGINFIDTYIRSGLYP-PPSLPSGLGTE 64 Query: 108 GVAQVVAVGSNVTGLKPGDWVIPANAGLGTWRT-EAVFSEEALIQVPSDIPLQSAATLGV 166 V VGS V +K GD V+ A + LG + + + +++A I +P+ I + AA + Sbjct: 65 AAGIVSKVGSGVKHIKAGDRVVYAQSALGAYSSVHNIIADKAAI-LPAAISFEQAAASFL 123 Query: 167 NPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSD 226 T Y +L +++P + + +A+ GVG Q A ALG + I V QK Sbjct: 124 KGLTVYYLLRKTYEIKPDEQFLFHAAAGGVGLIACQWAKALGAKLIGTV---GTAQKAQS 180 Query: 227 RLKSLGAEHVITEEELRRPEMKNFFKDMPQPRLALNCVGGKSSTELLRQLARGGTMVTYG 286 LK+ GA VI E E + R+ + VG + L L R G MV++G Sbjct: 181 ALKA-GAWQVINYREEDLVERLKEITGGKKVRVVYDSVGRDTWERSLDCLQRRGLMVSFG 239 Query: 287 GMAKQPVVASVSLLIFKDL--------KLRGFWLSQWKKDHSPDQFKELILTLCDLIRRG 338 + V V+L I L+G+ ++ ++ E L LI G Sbjct: 240 NSSG--AVTGVNLGILNQKGSLYVTRPSLQGYITTR-------EELTEASNELFSLIASG 290 Query: 339 QLTAPACSQ--VPLQDYQSALE 358 + Q PL+D Q A E Sbjct: 291 VIKVDVAEQQKYPLKDAQRAHE 312 >1WLY-A nrPDB Length = 333 Score = 63.9 bits (154), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 64/264 (24%), Positives = 107/264 (40%), Gaps = 14/264 (5%) Query: 99 ELPAVGGNEGVAQVVAVGSNVTGLKPGDWVIPANAGLGTWRTEAVFSEEALIQVPSDIPL 158 E P V G E A V VG VT G+ V LG + E ++ E LI+VP D+ L Sbjct: 59 EPPIVVGFEAAAVVEEVGPGVTDFTVGERVCTCLPPLGAYSQERLYPAEKLIKVPKDLDL 118 Query: 159 QSA--ATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVR 216 A L + TA +L +++PGD V+ +A+ G+G ++ A LG I V Sbjct: 119 DDVHLAGLMLKGMTAQYLLHQTHKVKPGDYVLIHAAAGGMGHIMVPWARHLGATVIGTV- 177 Query: 217 DRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFFKDMPQPRLALNCVGGKSSTELLRQL 276 ++ ++ + LG H I E+ + + +G + + L L Sbjct: 178 ---STEEKAETARKLGCHHTINYSTQDFAEVVREITGGKGVDVVYDSIGKDTLQKSLDCL 234 Query: 277 ARGGTMVTYGGMAKQPVVASVSLLIFKDLKLRGFWL----SQWKKDHSPDQFKELILTLC 332 G YG + + + + +DL +RG + W + + E L Sbjct: 235 RPRGMCAAYGHASG----VADPIRVVEDLGVRGSLFITRPALWHYMSNRSEIDEGSKCLF 290 Query: 333 DLIRRGQLTAPACSQVPLQDYQSA 356 D ++ G L + PL++ +A Sbjct: 291 DAVKAGVLHSSVAKTFPLREAAAA 314 >3JYN-A nrPDB Length = 325 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 76/300 (25%), Positives = 130/300 (43%), Gaps = 12/300 (4%) Query: 56 KVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPELPAVGGNEGVAQVVAV 115 +V+E + E A V V+ A +N D G Y P LP+ G EG V AV Sbjct: 14 EVLEYVDFEPEAPGPQAVVVRNKAIGLNFIDTYYRSGLYP-APFLPSGLGAEGAGVVEAV 72 Query: 116 GSNVTGLKPGDWVIPANAGLGTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYRML 175 G VT K GD V LG + V E L+++ + + AA L + T +L Sbjct: 73 GDEVTRFKVGDRVAYGTGPLGAYSEVHVLPEANLVKLADSVSFEQAAALMLKGLTVQYLL 132 Query: 176 MDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEH 235 Q++PG+ ++ +A+ GVG Q A ALG + I V + + K+LGA Sbjct: 133 RQTYQVKPGEIILFHAAAGGVGSLACQWAKALGAKLIGTVSS----PEKAAHAKALGAWE 188 Query: 236 VI--TEEELRRPEMKNFFKDMPQPRLALNCVGGKSSTELLRQLARGGTMVTYGGMAKQPV 293 I + E++ + ++ D + + + VG + L +A G +V++G + Sbjct: 189 TIDYSHEDVAKRVLE--LTDGKKCPVVYDGVGQDTWLTSLDSVAPRGLVVSFGNASGPVS 246 Query: 294 VASVSLLIFKD-LKLRGFWLSQWKKDHSPDQFKELILTLCDLIRRGQLTAPACSQVPLQD 352 ++ +L KD + + L + ++ + + L D++ G+L Q L+D Sbjct: 247 GVNLGILAQKDSVYVTRPTLGSYA--NNAQNLQTMADELFDMLASGKLKVDGIEQYALKD 304 >1U3W-A nrPDB Length = 374 Score = 61.2 bits (147), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 64/249 (25%), Positives = 102/249 (40%), Gaps = 60/249 (24%) Query: 56 KVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPELPAVGGNEGVAQVVAV 115 K ++ +E+A + +VR+KM+AA I SD +++ GN + LP + G+E V +V Sbjct: 19 KPFSIEEVEVAPPKAHEVRIKMVAAGICRSDEHVVSGN--LVTPLPVILGHEAAGIVESV 76 Query: 116 GSNVTGLKPGDWVIP----------------AN--------------------------- 132 G VT +KPGD VIP +N Sbjct: 77 GEGVTTVKPGDKVIPLFTPQCGKCRICKNPESNYCLKNDLGNPRGTLQDGTRRFTCSGKP 136 Query: 133 ----AGLGTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVI 188 G+ T+ V E A+ ++ + PL+ +G T Y + ++ PG S Sbjct: 137 IHHFVGVSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTPG-STC 195 Query: 189 QNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRL---KSLGAEHVITEEELRRP 245 GVG +V+ A G I V DI K D+ K LGA I ++ ++P Sbjct: 196 AVFGLGGVGLSVVMGCKAAGAARIIAV----DINK--DKFAKAKELGATECINPQDYKKP 249 Query: 246 EMKNFFKDM 254 ++ K+M Sbjct: 250 -IQEVLKEM 257 >4CPD-A nrPDB Length = 347 Score = 61.2 bits (147), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 79/271 (29%), Positives = 119/271 (43%), Gaps = 42/271 (15%) Query: 72 DVRVKMLAAPINPSDINMIQGNYGFLPELPAVGGNEGVAQVVAVGSNVTGLKPGDWVI-P 130 D V++ A I SD+++ G LP +V G+E V QV AVG + L+PGDWV+ P Sbjct: 27 DALVRVHLAGICGSDLHLYHGKIPVLPG--SVLGHEFVGQVEAVGEGIQDLQPGDWVVGP 84 Query: 131 ANAGLGTW-----------------------------RTEAV---FSEEALIQVPSDIPL 158 + GT + E + FS L ++P ++ Sbjct: 85 FHIACGTCPYCRRHQYNLCERGGVYGYGPMFGNLQGAQAEILRVPFSNVNLRKLPPNLSP 144 Query: 159 QSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDR 218 + A G TAY L+ QL+PGDSV + VG I++A LG I + DR Sbjct: 145 ERAIFAGDILSTAYGGLIQ-GQLRPGDSVAVIGAGP-VGLMAIEVAQVLGASKILAI-DR 201 Query: 219 PDIQKLSDRLKSLGAEHVITEEELRRPEMKNFFKDMPQPRLALNCVGGKSSTELLRQLAR 278 I + +R SLGA + E+E +++ D P L L VGG ++ L ++ R Sbjct: 202 --IPERLERAASLGAIPINAEQENPVRRVRSETND-EGPDLVLEAVGGAATLSLALEMVR 258 Query: 279 GGTMVTYGGMAKQPVVA-SVSLLIFKDLKLR 308 G V+ G+ P ++ + KDL R Sbjct: 259 PGGRVSAVGVDNAPSFPFPLASGLVKDLTFR 289 >4EYE-A nrPDB Length = 342 Score = 60.8 bits (146), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 80/304 (26%), Positives = 133/304 (43%), Gaps = 17/304 (5%) Query: 73 VRVKMLAAPINPSDINMIQGNYGFLPELPAVGGNEGVAQVVAVGSNVTGLKPGDWVIPAN 132 V V + AA + D M +G Y E P V G E A VV +G+KPGD V+ N Sbjct: 51 VVVDVKAAGVCFPDYLMTKGEYQLKMEPPFVPGIE-TAGVVRSAPEGSGIKPGDRVMAFN 109 Query: 133 AGLGTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNAS 192 +G + + ++ P + A L N T Y QL+ G++V+ + Sbjct: 110 F-IGGYAERVAVAPSNILPTPPQLDDAEAVALIANYHTMYFAYARRGQLRAGETVLVLGA 168 Query: 193 NSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEE----LRRPEMK 248 G+G A IQIA +G + I VV + ++ +KS+GA+ V+ EE R Sbjct: 169 AGGIGTAAIQIAKGMGAKVIAVV----NRTAATEFVKSVGADIVLPLEEGWAKAVREATG 224 Query: 249 NFFKDMPQPRLALNCVGGKSSTELLRQLARGGTMVTYGGMAKQPVVASVSLLIFKDLKLR 308 DM ++ +GG + + +R LA G ++ G A V+ L+ ++ L Sbjct: 225 GAGVDM-----VVDPIGGPAFDDAVRTLASEGRLLVVGFAAGGIPTIKVNRLLLRNASLI 279 Query: 309 GFWLSQWKKDHSPDQFKELILTLCDLIRRGQLTAPACSQVPLQDYQSALEASMKPFISSK 368 G ++ + H+ D E L L+ G + P +++PL + + AL+ + K Sbjct: 280 GVAWGEFLRTHA-DYLYETQAGLEKLVAEG-MRPPVSARIPLSEGRQALQDFADGKVYGK 337 Query: 369 QILT 372 +L Sbjct: 338 MVLV 341 >4Z6K-A nrPDB Length = 346 Score = 59.3 bits (142), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 68/257 (26%), Positives = 111/257 (43%), Gaps = 36/257 (14%) Query: 58 VELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPELPAVGGNEGVAQVVAVGS 117 ++++ +++ ++ VKM A+ + +D++ ++G++ P P + G+EGV + AVG Sbjct: 13 LQIEEVDIPTPGAGEIVVKMQASGVCHTDLHAVEGDWPVKPSPPFIPGHEGVGLITAVGE 72 Query: 118 NVTGLKPGD-----WVIPA----NAGLGTWRT------------EAVFSEEALIQ----- 151 VT +K GD W+ A LG W T F+E L Sbjct: 73 GVTHVKEGDRVGVAWLYSACGHCTHCLGGWETLCESQQNSGYSVNGSFAEYVLANANYVG 132 Query: 152 -VPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLR 210 +P + A + T Y+ L +PGD V+ + G+G +Q A A+GL Sbjct: 133 IIPESVDSIEIAPVLCAGVTVYKGL-KMTDTKPGDWVVISGI-GGLGHMAVQYAIAMGL- 189 Query: 211 TINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFFKDMPQPRLAL-NCVGGKSS 269 NV D KL+ K LGA+ + + E K++ AL V K+ Sbjct: 190 --NVAAVDIDDDKLA-FAKKLGAKVTVNAKNTDPAEY--LQKEIGGAHGALVTAVSAKAF 244 Query: 270 TELLRQLARGGTMVTYG 286 + L L RGGT+V G Sbjct: 245 DQALSMLRRGGTLVCNG 261 >1HSZ-A nrPDB Length = 374 Score = 58.9 bits (141), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 60/247 (24%), Positives = 99/247 (40%), Gaps = 56/247 (22%) Query: 56 KVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPELPAVGGNEGVAQVVAV 115 K ++++E+A + +VR+KM+A I +D +++ GN + LP + G+E V +V Sbjct: 19 KPFSIEDVEVAPPKAYEVRIKMVAVGICRTDDHVVSGN--LVTPLPVILGHEAAGIVESV 76 Query: 116 GSNVTGLKPGDWVIPANA------------------------------------------ 133 G VT +KPGD VIP Sbjct: 77 GEGVTTVKPGDKVIPLFTPQCGKCRVCKNPESNYCLKNDLGNPRGTLQDGTRRFTCRGKP 136 Query: 134 -----GLGTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVI 188 G T+ V E A+ ++ + PL+ +G T Y ++ ++ PG S Sbjct: 137 IHHFLGTSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVNVAKVTPG-STC 195 Query: 189 QNASNSGVG-QAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEM 247 GVG AV+ AA R I V ++ K K LGA I ++ ++P + Sbjct: 196 AVFGLGGVGLSAVMGCKAAGAARIIAVDINKDKFAK----AKELGATECINPQDYKKP-I 250 Query: 248 KNFFKDM 254 + K+M Sbjct: 251 QEVLKEM 257 >5K1S-A nrPDB Length = 362 Score = 58.5 bits (140), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 68/277 (24%), Positives = 121/277 (43%), Gaps = 48/277 (17%) Query: 72 DVRVKMLAAPINPSDINMIQGNYGFLPE--LPAVGGNEGVAQVVAVGSNVTGLKPGDWVI 129 +V +++ A + D+ +GN LP +PA+ G+E +V+ VG + G K GD Sbjct: 46 EVLLRVHACGVCYHDVINRRGN---LPRTSVPAILGHEAAGEVIEVGPDTPGWKTGDRAA 102 Query: 130 P-----------ANAGLGTW-RTEA-VFSEE--------------ALIQVPSDIPLQSAA 162 +G + +T+ F EE L +VP+ +P AA Sbjct: 103 TLQRMSCGDCALCRSGRNSLCKTDNRFFGEELPGGYAQFMVAPVGGLGRVPASLPWNEAA 162 Query: 163 TLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQ 222 T+ TA + +++ G++V+ ++ GVG + +Q+A G R I V +Q Sbjct: 163 TVCCTTGTAVHTVRTRGKVRAGETVLITGASGGVGLSSVQLARLDGARVIAVTSSEAKVQ 222 Query: 223 KLSDRLKSLGAEHVITEEELRRPEMKNFFKDMPQPR------LALNCVGGKSSTELLRQL 276 LK GA+ VI L +F D+ + +A+ VG + + L+ + Sbjct: 223 A----LKEAGADEVIVSRGL------DFASDVRKRTQGAGVDVAVEIVGSATFDQTLKSM 272 Query: 277 ARGGTMVTYGGMAKQPVVASVSLLIFKDLKLRGFWLS 313 A GG +V G + V + L+I K+L++ G + + Sbjct: 273 APGGRVVVVGNLESGMVQLNPGLVIVKELEILGAYAT 309 >3TQH-A nrPDB Length = 321 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 68/253 (26%), Positives = 112/253 (44%), Gaps = 25/253 (9%) Query: 42 RVRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPE-- 99 ++A+ + G P KV++L + R + + +K+ AA +NP D G+ GF+ + Sbjct: 6 EMKAIQFDQFG-PPKVLKLVDTPTPEYRKNQMLIKVHAASLNPIDYKTRNGS-GFVAKKL 63 Query: 100 ---LPAVGGNEGVAQVVAVGSNVTGLKPGDWVIPANAGL----GTWRTEAVFSEEALIQV 152 LP+ G + +V+ +GS+V + GD V+ AG + S + +IQ Sbjct: 64 KNNLPSGLGYDFSGEVIELGSDVNNVNIGDKVMGI-AGFPDHPCCYAEYVCASPDTIIQK 122 Query: 153 PSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTI 212 + AA+L TA + L E ++ GD V+ +A GVG IQ+A G I Sbjct: 123 LEKLSFLQAASLPTAGLTALQALNQAE-VKQGDVVLIHAGAGGVGHLAIQLAKQKGTTVI 181 Query: 213 NVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFFKDMPQPRLA-LNCVGGKSSTE 271 R LK+LGAE I E ++F + P A ++ VGG + Sbjct: 182 TTASKRN-----HAFLKALGAEQCINYHE------EDFLLAISTPVDAVIDLVGGDVGIQ 230 Query: 272 LLRQLARGGTMVT 284 + L G +V+ Sbjct: 231 SIDCLKETGCIVS 243 >1HSO-A nrPDB Length = 374 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 58/247 (23%), Positives = 98/247 (39%), Gaps = 56/247 (22%) Query: 56 KVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPELPAVGGNEGVAQVVAV 115 K ++ +E+A + +VR+KM+A I +D +++ G + LP + G+E V +V Sbjct: 19 KPFSIEEVEVAPPKAHEVRIKMVAVGICGTDDHVVSGT--MVTPLPVILGHEAAGIVESV 76 Query: 116 GSNVTGLKPGDWVIPANA------------------------------------------ 133 G VT +KPGD VIP Sbjct: 77 GEGVTTVKPGDKVIPLAIPQCGKCRICKNPESNYCLKNDVSNPQGTLQDGTSRFTCRRKP 136 Query: 134 -----GLGTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVI 188 G+ T+ V E A+ ++ + PL+ +G T Y ++ ++ PG S Sbjct: 137 IHHFLGISTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVNVAKVTPG-STC 195 Query: 189 QNASNSGVG-QAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEM 247 GVG A++ AA R I V ++ K K LGA I ++ ++P + Sbjct: 196 AVFGLGGVGLSAIMGCKAAGAARIIAVDINKDKFAK----AKELGATECINPQDYKKP-I 250 Query: 248 KNFFKDM 254 + K+M Sbjct: 251 QEVLKEM 257 >2OBY-A nrPDB Length = 338 Score = 55.5 bits (132), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 64/235 (27%), Positives = 104/235 (44%), Gaps = 7/235 (2%) Query: 71 SDVRVKMLAAPINPSDINMIQGNYGFLPELPAVGGNEGVAQVVAVGSNVTG-LKPGDWVI 129 +V +K+ A+ +N +D+ QG Y P + G E V +G G K GD + Sbjct: 34 GEVLLKVAASALNRADLMQRQGQYDPPPGASNILGLEASGHVAELGPGCQGHWKIGDTAM 93 Query: 130 PANAGLGTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQ 189 G G + V E L+ +P + L AA + TA+++L +Q GD V+ Sbjct: 94 ALLPGGGQAQYVTV-PEGLLMPIPEGLTLTQAAAIPEAWLTAFQLLHLVGNVQAGDYVLI 152 Query: 190 NASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKN 249 +A SGVG A IQ+ G + + +Q ++++L + A +E+ +K Sbjct: 153 HAGLSGVGTAAIQLTRMAGAIPLVTAGSQKKLQ-MAEKLGA-AAGFNYKKEDFSEATLK- 209 Query: 250 FFKDMPQPRLALNCVGGKSSTELLRQLARGGTMVTYGGMAKQPVVASV-SLLIFK 303 F L L+C+GG + + LA G V YG M + + S L+FK Sbjct: 210 -FTKGAGVNLILDCIGGSYWEKNVNCLALDGRWVLYGLMGGGDINGPLFSKLLFK 263 >3UOG-A nrPDB Length = 363 Score = 55.1 bits (131), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 73/262 (27%), Positives = 104/262 (39%), Gaps = 28/262 (10%) Query: 72 DVRVKMLAAPINPSDINMIQGNYGFLPELPAVGGNEGVAQVVAVGSNVTGLKPGDWVIPA 131 D+ V+ LA +N D +++ G P V ++ V AVG +VT +PGD VI Sbjct: 55 DIIVRTLAVSLNYRDKLVLETGMGLDLAFPFVPASDMSGVVEAVGKSVTRFRPGDRVIST 114 Query: 132 NA-----GL--GTWRTEA----------------VFSEEALIQVPSDIPLQSAATLGVNP 168 A GL GT RT A V E + P + A+TL Sbjct: 115 FAPGWLDGLRPGTGRTPAYETLGGAHPGVLSEYVVLPEGWFVAAPKSLDAAEASTLPCAG 174 Query: 169 CTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRL 228 TA+ L++ L+ GD V+ + GV +QIA A G I R +KL DR Sbjct: 175 LTAWFALVEKGHLRAGDRVVVQGTG-GVALFGLQIAKATGAEVIVTSSSR---EKL-DRA 229 Query: 229 KSLGAEHVITEEELRRPEMKNFFKDMPQPRLALNCVGGKSSTELLRQLARGGTMVTYGGM 288 +LGA+H I E E L GG + L+ +A G + G + Sbjct: 230 FALGADHGINRLEEDWVERVYALTGDRGADHILEIAGGAGLGQSLKAVAPDGRISVIGVL 289 Query: 289 AKQPVVASVSLLIFKDLKLRGF 310 V V L+ K ++G Sbjct: 290 EGFEVSGPVGPLLLKSPVVQGI 311 >2Y05-A nrPDB Length = 328 Score = 54.7 bits (130), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 50/203 (24%), Positives = 91/203 (44%), Gaps = 17/203 (8%) Query: 138 WRTEAVFS----EEALIQVPSDIPLQSA-ATLGVNPCTAYRMLMDFEQLQPGDSVIQNAS 192 W T ++ E+ L + P IPL A T+G+ TAY L++ ++ G++V+ NA+ Sbjct: 90 WTTHSISDGKDLEKLLTEWPDTIPLSLALGTVGMPGLTAYFGLLEICGVKGGETVMVNAA 149 Query: 193 NSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFFK 252 VG V QIA G + + V + L+ LG + V + + E + K Sbjct: 150 AGAVGSVVGQIAKLKGCKVVGAVGSDEKVA----YLQKLGFDVVFNYKTVESLE-ETLKK 204 Query: 253 DMPQPR-LALNCVGGKSSTELLRQLARGGTMV------TYGGMAKQPVVASVSLLIFKDL 305 P + VGG+ S ++ Q+ + G + TY P ++I+++L Sbjct: 205 ASPDGYDCYFDNVGGEFSNTVIGQMKKFGRIAICGAISTYNRTGPLPPGPPPEIVIYQEL 264 Query: 306 KLRGFWLSQWKKDHSPDQFKELI 328 ++ F + +W+ D K+L+ Sbjct: 265 RMEAFVVYRWQGDARQKALKDLL 287 >3QWB-A nrPDB Length = 334 Score = 54.3 bits (129), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 71/279 (25%), Positives = 122/279 (43%), Gaps = 19/279 (6%) Query: 87 INMIQGNY--GFLP-ELPAVGGNEGVAQVVAVGSNVTGLKPGDWV-IPANAGLGTWRTEA 142 +N I+ + G P E P V G E VVA G VT + GD V +N+ + Sbjct: 47 VNYIESYFRKGIYPCEKPYVLGREASGTVVAKGKGVTNFEVGDQVAYISNSTFAQY--SK 104 Query: 143 VFSEEALIQVP---SDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQA 199 + S+ ++++P SD L+ A + TA + ++ GD V+ A+ GVG Sbjct: 105 ISSQGPVMKLPKGTSDEELKLYAAGLLQVLTALSFTNEAYHVKKGDYVLLFAAAGGVGLI 164 Query: 200 VIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVI--TEEELRRPEMKNFFKDMPQP 257 + Q+ G TI V ++ K GAE++I ++E++ R +K F + Sbjct: 165 LNQLLKMKGAHTIAVASTDEKLK----IAKEYGAEYLINASKEDILRQVLK--FTNGKGV 218 Query: 258 RLALNCVGGKSSTELLRQLARGGTMVTYGGMAKQPVVASVSLLIFKDLKLRGFWLSQWKK 317 + + VG + L L R G V++G + S++ L K++ L L + Sbjct: 219 DASFDSVGKDTFEISLAALKRKGVFVSFGNASGLIPPFSITRLSPKNITLVRPQLYGYIA 278 Query: 318 DHSPDQFKELILTLCDLIRRGQLTAPACSQVPLQDYQSA 356 D P+++K L+ +L PL+DY++A Sbjct: 279 D--PEEWKYYSDEFFGLVNSKKLNIKIYKTYPLRDYRTA 315 >3PII-A nrPDB Length = 339 Score = 54.3 bits (129), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 55/208 (26%), Positives = 94/208 (45%), Gaps = 33/208 (15%) Query: 58 VELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPELPAVGGNEGVAQVVAVGS 117 +++K +E + +V V++ A + +D++ G++ P+LP + G+EGV V VG Sbjct: 13 LKIKEVEKPTISYGEVLVRIKACGVCHTDLHAAHGDWPVKPKLPLIPGHEGVGIVEEVGP 72 Query: 118 NVTGLKPGD-----WVIPA-------------------NAGL---GTWRTEAVFSEEALI 150 VT LK GD W+ A NAG G + + + ++ Sbjct: 73 GVTHLKVGDRVGIPWLYSACGHCDYCLSGQETLCEHQKNAGYSVDGGYAEYCRAAADYVV 132 Query: 151 QVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLR 210 ++P ++ + AA + T Y+ L +PG+ V G G +Q A A+GL Sbjct: 133 KIPDNLSFEEAAPIFCAGVTTYKAL-KVTGAKPGEWVAIYGIG-GFGHVAVQYAKAMGLN 190 Query: 211 TINVVRDRPDIQKLSDRLKSLGAEHVIT 238 + V D D +KL + K LGA+ V+ Sbjct: 191 VVAV--DIGD-EKL-ELAKELGADLVVN 214 >4IDE-A nrPDB Length = 332 Score = 53.5 bits (127), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 73/269 (27%), Positives = 118/269 (43%), Gaps = 30/269 (11%) Query: 40 PARVRALVYGHHGDPAKVVELK-NLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLP 98 P+ +A VY +G + V++ ++ + ++ V +K++AA +NP D G + Sbjct: 21 PSVNKAWVYSEYGKTSDVLKFDPSVAVPEIKEDQVLIKVVAASLNPVDFKRALGYFKDTD 80 Query: 99 E-LPAVGGNEGVAQVVAVGSNVTGLKPGDWVI----------PANAGLGTWRTEAVFSEE 147 LP + G + VV VGS VT K GD V P G T A E Sbjct: 81 SPLPTIPGYDVAGVVVKVGSQVTKFKVGDEVYGDLNETALVNPTRFGSLAEYTAA--DER 138 Query: 148 ALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAA-A 206 L P ++ AA+L + TA+ L + +L G SV+ GVG +IQ+A Sbjct: 139 VLAHKPKNLSFIEAASLPLAIETAHEGL-ERAELSAGKSVLVLGGAGGVGTHIIQLAKHV 197 Query: 207 LGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFFKDMPQP-RLALNCVG 265 G + +KL D L++LGA+ I K F+D+P+ + + VG Sbjct: 198 FGASKVAATA---STKKL-DLLRTLGADLAID-------YTKENFEDLPEKFDVVYDAVG 246 Query: 266 GKSSTELLRQLARGGTMVTYGGMAKQPVV 294 + + ++ + GG +VT G A P + Sbjct: 247 --ETDKAVKAVKEGGKVVTIVGPATPPAI 273 >4UEJ-A nrPDB Length = 346 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 66/274 (24%), Positives = 116/274 (42%), Gaps = 43/274 (15%) Query: 72 DVRVKMLAAPINPSDINMIQGNYGFLPELPAVGGNEGVAQVVAVGSNVTGLKPGDWV--I 129 +VRVK+ ++ + SD+ I N P G+E + AVGS V L PGD V + Sbjct: 27 EVRVKIASSGLCGSDLPRIFKNGAHY--YPITLGHEFSGYIDAVGSGVDDLHPGDAVACV 84 Query: 130 P------------------ANAGLGTWRTEAVFSEEALIQ------VPSDIPLQSAATLG 165 P A R + F+E +++ +P+D+P++ A Sbjct: 85 PLLPCFTCPECLKGFYSQCAKYDFIGSRRDGGFAEYIVVKRKNVFALPTDMPIEDGAF-- 142 Query: 166 VNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLS 225 + P T Q +VI + + +G IQ A ALG +++ + DI S Sbjct: 143 IEPITVGLHAFHLAQGCENKNVIIIGAGT-IGLLAIQCAVALGAKSVTAI----DIS--S 195 Query: 226 DRL---KSLGAEHVITEEELRRPEMKNFFKDMPQPRLALNCVGGKSSTELLRQLARGGTM 282 ++L KS GA E+ P+M++ +++ +L L G + EL ++A Sbjct: 196 EKLALAKSFGAMQTFNSSEMSAPQMQSVLRELRFNQLILETAGVPQTVELAVEIAGPHAQ 255 Query: 283 VTYGGMAKQPV---VASVSLLIFKDLKLRGFWLS 313 + G Q + A+ ++ K+L + G W++ Sbjct: 256 LALVGTLHQDLHLTSATFGKILRKELTVIGSWMN 289 >3MEQ-A nrPDB Length = 365 Score = 52.8 bits (125), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 68/265 (25%), Positives = 113/265 (42%), Gaps = 35/265 (13%) Query: 73 VRVKMLAAPINPSDINMIQGNYGFLPELPAVGGNEGVAQVVAVGSNVTGLKPGD-----W 127 ++V + A+ + +D++ +G++ P P + G+EGV V AVGS V +K GD W Sbjct: 53 IQVAIQASGVCHTDLHAAEGDWPVKPNPPFIPGHEGVGFVSAVGSGVKHVKEGDRVGIPW 112 Query: 128 VIPANAG----LGTWRT-----------------EAVFSEEALI-QVPSDIPLQSAATLG 165 + A LG W T E V ++ + +P +I A + Sbjct: 113 LYTACGHCRHCLGGWETLCEEQLNTGYSVNGGFAEYVVADPNFVGHLPKNIDFNEIAPVL 172 Query: 166 VNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLS 225 T Y+ L +PGD V+ + G+G +Q A A+GL NV D +KL Sbjct: 173 CAGVTVYKGL-KVTDTKPGDWVVISGI-GGLGHMAVQYARAMGL---NVAAVDIDDRKL- 226 Query: 226 DRLKSLGAEHVITEEELRRPEMK-NFFKDMPQPRLALNCVGGKSSTELLRQLARGGTMVT 284 D + LGA + + + P D + + V K+ + L +ARGGT V+ Sbjct: 227 DLARRLGATVTVNAKTVADPAAYIRKETDGGAQGVLVTAVSPKAFEQALGMVARGGT-VS 285 Query: 285 YGGMAKQPVVASVSLLIFKDLKLRG 309 G+ S+ ++ + +RG Sbjct: 286 LNGLPPGDFPLSIFNMVLNGVTVRG 310 >1H2B-A nrPDB Length = 359 Score = 52.8 bits (125), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 69/266 (25%), Positives = 122/266 (45%), Gaps = 48/266 (18%) Query: 72 DVRVKMLAAPINPSDINMIQGNYGFL--PELPAVGGNEGVAQVVAVGSNVTGLKPGDWVI 129 DV V++ A + +D++++QG + L P+LP G+E V + V V GL+ GD VI Sbjct: 43 DVIVRIAGAGVCHTDLHLVQGMWHELLQPKLPYTLGHENVGYIEEVAEGVEGLEKGDPVI 102 Query: 130 --PA------------------NAGLGTWRTEAVFSE------EALIQVPSDI---PLQS 160 PA N + F+E ++I++P DI L Sbjct: 103 LHPAVTDGTCLACRAGEDMHCENLEFPGLNIDGGFAEFMRTSHRSVIKLPKDISREKLVE 162 Query: 161 AATLGVNPCTAYRMLMDFEQ-LQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRP 219 A L TAYR + + L PG + + G+G +Q+ + T+ + + Sbjct: 163 MAPLADAGITAYRAVKKAARTLYPG-AYVAIVGVGGLGHIAVQLLKVMTPATVIALDVKE 221 Query: 220 DIQKLSDRLKSLGAEHVITEEELRRPEMKNFFKDMPQPR---LALNCVGGKSSTE----L 272 + KL++R LGA+HV+ + RR +K ++ + R +A++ VG +++ + L Sbjct: 222 EKLKLAER---LGADHVV---DARRDPVKQVM-ELTRGRGVNVAMDFVGSQATVDYTPYL 274 Query: 273 LRQLARGGTMVTYGGMAKQPVVASVS 298 L ++ R +V YGG + P + +S Sbjct: 275 LGRMGR-LIIVGYGGELRFPTIRVIS 299 >1MC5-A nrPDB Length = 374 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 60/259 (23%), Positives = 100/259 (38%), Gaps = 65/259 (25%) Query: 39 EPARVRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLP 98 E + +A V G P + ++ +E+A + +VR+K++A + +D + G P Sbjct: 4 EVIKCKAAVAWEAGKP---LSIEEIEVAPPKAHEVRIKIIATAVCHTDAYTLSGAD---P 57 Query: 99 E--LPAVGGNEGVAQVVAVGSNVTGLKPGDWVIP-------------------------- 130 E P + G+EG V +VG VT LK GD VIP Sbjct: 58 EGCFPVILGHEGAGIVESVGEGVTKLKAGDTVIPLYIPQCGECKFCLNPKTNLCQKIRVT 117 Query: 131 ---------------------ANAGLGTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPC 169 G T+ V ++ ++ ++ PL LG Sbjct: 118 QGKGLMPDGTSRFTCKGKTILHYMGTSTFSEYTVVADISVAKIDPLAPLDKVCLLGCGIS 177 Query: 170 TAYRMLMDFEQLQPGDSVIQNASNSGVGQAVI---QIAAALGLRTINVVRDRPDIQKLSD 226 T Y ++ +L+PG SV GVG AVI ++A A + +++ +D+ Sbjct: 178 TGYGAAVNTAKLEPG-SVCAVFGLGGVGLAVIMGCKVAGASRIIGVDINKDK------FA 230 Query: 227 RLKSLGAEHVITEEELRRP 245 R K GA I ++ +P Sbjct: 231 RAKEFGATECINPQDFSKP 249 >1V3V-A nrPDB Length = 333 Score = 52.0 bits (123), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 68/292 (23%), Positives = 124/292 (42%), Gaps = 48/292 (16%) Query: 59 ELKNLELAAVRGSDVRVKMLAAPINP----SDINMIQGNYGFLPELPAVGGNEGVAQVVA 114 ELK +EL ++ +V ++ L ++P + + +G AV + VA+VV Sbjct: 27 ELKTVELPPLKNGEVLLEALFLSVDPYMRIASKRLKEG---------AVMMGQQVARVVE 77 Query: 115 VGSNVTGLKPGDWVIPANAGLGTWRTEAVFS----EEALIQVPSDIPLQSA-ATLGVNPC 169 ++ P ++ A +G W T + E+ L + P +PL A T+G+ Sbjct: 78 SKNSAF---PAGSIVLAQSG---WTTHFISDGKGLEKLLTEWPDKLPLSLALGTIGMPGL 131 Query: 170 TAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLK 229 TAY L++ ++ G++V+ +A+ VG V QIA G + + I LK Sbjct: 132 TAYFGLLEVCGVKGGETVLVSAAAGAVGSVVGQIAKLKGCKVVGAAGSDEKIA----YLK 187 Query: 230 SLGAEHVIT-------EEELRRPEMKNFFKDMPQPRLALNCVGGKSSTELLRQL------ 276 +G + EE L++ + + VGG+ +L Q+ Sbjct: 188 QIGFDAAFNYKTVNSLEEALKKASPDGY-------DCYFDNVGGEFLNTVLSQMKDFGKI 240 Query: 277 ARGGTMVTYGGMAKQPVVASVSLLIFKDLKLRGFWLSQWKKDHSPDQFKELI 328 A G + Y M + P S +I+K L++ GF + +W+ D ++L+ Sbjct: 241 AICGAISVYNRMDQLPPGPSPESIIYKQLRIEGFIVYRWQGDVREKALRDLM 292 >4RVS-A nrPDB Length = 329 Score = 52.0 bits (123), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 55/175 (31%), Positives = 81/175 (46%), Gaps = 13/175 (7%) Query: 72 DVRVKMLAAPINPSDINMIQGNYGFLP-ELPAVGGNEGVAQVVAVGSNVTG----LKPGD 126 ++ +K A +N D G Y P ELP V G+E V AVG VT + GD Sbjct: 30 ELLIKAEAIGVNFIDTYFRSGQY---PRELPFVIGSEVCGTVEAVGPGVTAADTAISVGD 86 Query: 127 WVIPANAGLGTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDS 186 V+ A+A G + +VP D+ + AA+ + TA+ +L ++ GD+ Sbjct: 87 RVVSASAN-GAYAEFCTAPASLTAKVPDDVTSEVAASALLKGLTAHYLLKSVYPVKRGDT 145 Query: 187 VIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEE 241 V+ +A GVG + Q A LG+R I V + KLS K GA+ V+ E Sbjct: 146 VLVHAGAGGVGLILTQWATHLGVRVITTV-STAEKAKLS---KDAGADVVLDYPE 196 >5A3V-A nrPDB Length = 329 Score = 51.2 bits (121), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 60/221 (27%), Positives = 100/221 (45%), Gaps = 33/221 (14%) Query: 43 VRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYG-FLP-EL 100 + AL Y +G A +E + + + ++V +K+ A +NP D + +G FLP + Sbjct: 6 MHALQYNSYGGGAAGLEHVQVPVPTPKSNEVCLKLEATSLNPVDWKIQKGMIRPFLPRKF 65 Query: 101 PAVGGNEGVAQVVAVGSNVTGLKPGDWVIP--ANAGLGTWRTEAVFSEEALIQVPSDIPL 158 P + + +VV VGS V K GD V+ ++ G G AV +E+ ++ P ++ Sbjct: 66 PCIPATDVAGEVVEVGSGVKNFKAGDKVVAVLSHLGGGGLAEFAVATEKLTVKRPQEVGA 125 Query: 159 QSAATLGVNPCTAYRMLMDFEQLQ-----PGDSVIQNASNSGVGQAVIQIA--------A 205 AA L V TA + L + L+ +++ A++ GVG +Q+A A Sbjct: 126 AEAAALPVAGLTALQALTNPAGLKLDGTGKKANILVTAASGGVGHYAVQLAKLANAHVTA 185 Query: 206 ALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPE 246 G R I V KSLGA+ V+ + + PE Sbjct: 186 TCGARNIEFV-------------KSLGADEVL---DYKTPE 210 >1EE2-A nrPDB Length = 373 Score = 51.2 bits (121), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 27/75 (36%), Positives = 45/75 (60%), Gaps = 2/75 (2%) Query: 56 KVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPELPAVGGNEGVAQVVAV 115 K ++ +E+A + +VR+KM+AA I SD +++ G + LP + G+E V ++ Sbjct: 19 KPFSIEEVEVAPPKAHEVRIKMVAAGICRSDDHVVSGT--LVAPLPVIAGHEAAGIVESI 76 Query: 116 GSNVTGLKPGDWVIP 130 G VT ++PGD VIP Sbjct: 77 GEGVTTVRPGDKVIP 91 >4J6F-A nrPDB Length = 382 Score = 50.8 bits (120), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 70/303 (23%), Positives = 119/303 (39%), Gaps = 39/303 (12%) Query: 40 PARVRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPE 99 P + A++ HG K+V +++ + A +V +K+ A +N +D+ + +G YG + Sbjct: 31 PKTMTAVLLTGHGGLEKLVYSRDVPVPAPAAGEVLIKVTACGMNNTDVWVREGAYGTEDD 90 Query: 100 ---------------LPAVGGNEGVAQVVAVGSNVTGLKPGDWVIP-------------- 130 P + G + V +VAVG V + G+ V+ Sbjct: 91 PSAVSTWRRHGNTLTFPRIQGTDTVGHIVAVGEGVDRARIGERVMVDFSIYNRDDDSLAD 150 Query: 131 ----ANAGLGTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDS 186 + G + E V +D+ AT T RML + +L G++ Sbjct: 151 IDYMGHGRDGGYAEYMALPAENAHVVATDLTDIELATFCCAYLTGERML-ERARLAAGET 209 Query: 187 VIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPE 246 V+ ++ GVG A+IQ+A A G I V + L +GA+ V+T + E Sbjct: 210 VLVTGASGGVGSAIIQLARARGAVPIAVAGPGKEAAML-----DIGAQAVVTRGQGDLAE 264 Query: 247 MKNFFKDMPQPRLALNCVGGKSSTELLRQLARGGTMVTYGGMAKQPVVASVSLLIFKDLK 306 + + VGG +LL+ L G T G +A V + + K L+ Sbjct: 265 AVEAASGGRPIDVVADLVGGPLFNDLLKILRPEGRYTTAGAIAGPVVQLDLRTMYLKQLE 324 Query: 307 LRG 309 L G Sbjct: 325 LHG 327 >5YAT-A nrPDB Length = 350 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 74/335 (22%), Positives = 141/335 (42%), Gaps = 52/335 (15%) Query: 40 PARVRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPE 99 P +A+++ +G P +E K++ + + +++ + + + + +D++ +G++ + Sbjct: 6 PTTQKAVIFETNGGP---LEYKDIPVPKPKSNELLINVKYSGVCHTDLHAWKGDWPLDNK 62 Query: 100 LPAVGGNEGVAQVVAVGSNVTGLKPGDWV---------------------IPANAGLGTW 138 LP VGG+EG VVA G NVTG + GD+ A A L + Sbjct: 63 LPLVGGHEGAGVVVAYGENVTGWEIGDYAGIKWLNGSCLNCEYCIQGAESSCAKADLSGF 122 Query: 139 RTEAVFSEEAL------IQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNAS 192 + F + A ++P + L A + T Y+ L + L+ G V + + Sbjct: 123 THDGSFQQYATADATQAARIPKEADLAEVAPILCAGITVYKALKTAD-LRIGQWVAISGA 181 Query: 193 NSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVI--TEEELRRPEMKNF 250 G+G +Q A ALGLR + + + +KSLGAE + T+ + E++ Sbjct: 182 GGGLGSLAVQYAKALGLRVLGIDGGADK----GEFVKSLGAEVFVDFTKTKDVVAEVQKL 237 Query: 251 FKDMPQPRLALNCV--GGKSSTELLRQLARGGTMVTYGGMAKQPVVASVSLLIFKDLKLR 308 P + ++ S + +R L G +V G + V + V + K ++++ Sbjct: 238 TNGGPHGVINVSVSPHAINQSVQYVRTL---GKVVLVGLPSGAVVNSDVFWHVLKSIEIK 294 Query: 309 GFWLSQWKKDHSPDQFKELILTLCDLIRRGQLTAP 343 G ++ +E DL RG + AP Sbjct: 295 GSYVGN----------REDSAEAIDLFTRGLVKAP 319 >3COS-A nrPDB Length = 381 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 71/333 (21%), Positives = 122/333 (36%), Gaps = 70/333 (21%) Query: 42 RVRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPELP 101 + +A + G P + E+ E+A + +VR++++A + +D +I + L P Sbjct: 10 KCKAAIAWEAGKPLCIEEV---EVAPPKAHEVRIQIIATSLCHTDATVIDSKFEGLA-FP 65 Query: 102 AVGGNEGVAQVVAVGSNVTGLKPGDWVIPANA---------------------------- 133 + G+E V ++G VT +KPGD VIP A Sbjct: 66 VIVGHEAAGIVESIGPGVTNVKPGDKVIPLYAPLCRKCKFCLSPLTNLCGKISNLKSPAS 125 Query: 134 -----------------------GLGTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCT 170 G T+ V S+ L ++ D L+ LG T Sbjct: 126 DQQLMEDKTSRFTCKGKPVYHFFGTSTFSQYTVVSDINLAKIDDDANLERVCLLGCGFST 185 Query: 171 AYRMLMDFEQLQPGDSVIQNASNSGVG-QAVIQIAAALGLRTINVVRDRPDIQKLSDRLK 229 Y ++ ++ PG S GVG AV+ AA R I + + K K Sbjct: 186 GYGAAINNAKVTPG-STCAVFGLGGVGLSAVMGCKAAGASRIIGIDINSEKFVK----AK 240 Query: 230 SLGAEHVITEEELRRPEMKNFFKDMPQP--RLALNCVGGKSSTELLRQLARGG----TMV 283 +LGA + +L +P ++ ++ + AL+C GG + + G T + Sbjct: 241 ALGATDCLNPRDLHKP-IQEVIIELTKGGVDFALDCAGGSETMKAALDCTTAGWGSCTFI 299 Query: 284 TYGGMAKQPVVASVSLLIFKDLKLRGFWLSQWK 316 +K V L+I + + G + WK Sbjct: 300 GVAAGSKGLTVFPEELIIGR--TINGTFFGGWK 330 >1D1T-A nrPDB Length = 373 Score = 49.3 bits (116), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 25/71 (35%), Positives = 44/71 (61%), Gaps = 2/71 (2%) Query: 60 LKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPELPAVGGNEGVAQVVAVGSNV 119 ++ +E+A + +VR+K+LA I +D ++I+G + + P + G+E V ++G V Sbjct: 23 IEEIEVAPPKTKEVRIKILATGICRTDDHVIKGT--MVSKFPVIVGHEATGIVESIGEGV 80 Query: 120 TGLKPGDWVIP 130 T +KPGD VIP Sbjct: 81 TTVKPGDKVIP 91 >1P0F-A nrPDB Length = 373 Score = 48.9 bits (115), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 28/79 (35%), Positives = 50/79 (63%), Gaps = 4/79 (5%) Query: 53 DPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLP-ELPAVGGNEGVAQ 111 +P K + L+ + +A + +VR+K+LA+ I SD ++++ +P + P + G+E V Sbjct: 17 EPHKPLSLETITVAPPKAHEVRIKILASGICGSDSSVLKE---IIPSKFPVILGHEAVGV 73 Query: 112 VVAVGSNVTGLKPGDWVIP 130 V ++G+ VT +KPGD VIP Sbjct: 74 VESIGAGVTCVKPGDKVIP 92 >1YQX-A nrPDB Length = 366 Score = 47.8 bits (112), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 54/214 (25%), Positives = 82/214 (38%), Gaps = 39/214 (18%) Query: 62 NLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPELPAVGGNEGVAQVVAVGSNVTG 121 N A DVR K+L + SD++ I+ ++GF P V G+E V +V VGS V Sbjct: 33 NFSRRATGEEDVRFKVLYCGVCHSDLHSIKNDWGF-SMYPLVPGHEIVGEVTEVGSKVKK 91 Query: 122 LKPGDWV--------------------------IPANAGL--------GTWRTEAVFSEE 147 + GD V I A + G + V +E Sbjct: 92 VNVGDKVGVGCLVGACHSCESCANDLENYCPKMILTYASIYHDGTITYGGYSNHMVANER 151 Query: 148 ALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAAL 207 +I+ P ++PL A L T Y L F +PG + AV + A A Sbjct: 152 YIIRFPDNMPLDGGAPLLCAGITVYSPLKYFGLDEPGKHIGIVGLGGLGHVAV-KFAKAF 210 Query: 208 GLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEE 241 G + + V+ P K + LK+ GA+ + + Sbjct: 211 GSK-VTVISTSP--SKKEEALKNFGADSFLVSRD 241 >4DVJ-A nrPDB Length = 363 Score = 47.8 bits (112), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 58/209 (27%), Positives = 89/209 (42%), Gaps = 28/209 (13%) Query: 51 HGDPAKVVE---LKNLELA--AVRGSDVRVKMLAAPINPSDINMIQGNYGFLPELPAVG- 104 + PA + + L ++EL A G D+ V++ A +NP D Y P G Sbjct: 28 YNKPAPITDDASLLDIELPKPAPAGHDILVEVKAVSVNPVD-------YKVRRSTPPDGT 80 Query: 105 -----GNEGVAQVVAVGSNVTGLKPGDWVIPANAGL--GTWRTEAVFSEEALIQVPSDIP 157 G + V AVG +VT +PGD V A + + GT + E + + P + Sbjct: 81 DWKVIGYDAAGIVSAVGPDVTLFRPGDEVFYAGSIIRPGTNAEFHLVDERIVGRKPKTLD 140 Query: 158 LQSAATLGVNPCTAYRML---MDFEQLQPG--DSVIQNASNSGVGQAVIQIAAALGLRTI 212 AA L + TA+ +D + PG +++ GVG +QIA T+ Sbjct: 141 WAEAAALPLTSITAWEAFFDRLDVNKPVPGAAPAILIVGGAGGVGSIAVQIARQRTDLTV 200 Query: 213 NVVRDRPDIQKLSDRLKSLGAEHVITEEE 241 RP+ Q+ +KSLGA HVI + Sbjct: 201 IATASRPETQEW---VKSLGAHHVIDHSK 226 >6N7L-A nrPDB Length = 353 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 51/213 (23%), Positives = 95/213 (44%), Gaps = 35/213 (16%) Query: 40 PARVRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPE 99 P ++A V +G+P K+ E+ E +V VK++A + +D++ + G++ P+ Sbjct: 11 PKTMKAAVVQGYGEPLKIQEVPVREPGRY---EVLVKVMACGVCHTDLHAVDGDWPAKPK 67 Query: 100 LPAVGGNEGVAQVVAVGSNVTGLKPGD-----WVIPANAGL----------------GTW 138 +P + G+EGV VVA G + +K GD W+ A G + Sbjct: 68 MPLIPGHEGVGIVVACGPDAM-VKEGDAVGVPWLYSACGCCDYCITGWETLCEAQQNGGY 126 Query: 139 RTEAVFSEEALI------QVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNAS 192 + F+E + + S++ A + T Y+ L + E +PG+ V + Sbjct: 127 SVDGGFAEYVIADSRYVGHLKSNVNFLEIAPILCAGVTVYKGLKETET-KPGEWVAISGI 185 Query: 193 NSGVGQAVIQIAAALGLRT--INVVRDRPDIQK 223 G+G +Q A A+G+ I+V D+ ++ K Sbjct: 186 G-GLGHVAVQYAKAMGMHVAAIDVADDKLELAK 217 >2VN8-A nrPDB Length = 375 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 62/238 (26%), Positives = 94/238 (39%), Gaps = 34/238 (14%) Query: 71 SDVRVKMLAAPINPSDINMIQGNYGFLP---------------ELPAVGGNEGVAQVVAV 115 ++V VK+ AA +NP D+NM G YG E P G + V+ Sbjct: 51 NEVIVKVHAASVNPIDVNMRSG-YGATALNMKRDPLHVKIKGEEFPLTLGRDVSGVVMEC 109 Query: 116 GSNVTGLKPGD--WVIPANAGLGTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYR 173 G +V KPGD W GT V S + P + AA+L TA+ Sbjct: 110 GLDVKYFKPGDEVWAAVPPWKQGTLSEFVVVSGNEVSHKPKSLTHTQAASLPYVALTAWS 169 Query: 174 MLMDFEQLQ----PGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLK 229 + L G V+ ++ GVG IQ+ A V Q S+ ++ Sbjct: 170 AINKVGGLNDKNCTGKRVLILGASGGVGTFAIQVMKAWDAHVTAVCS-----QDASELVR 224 Query: 230 SLGAEHVITEEELRRPEMKNFFKDMPQPRLALNCVGGKSST---ELLRQLARGGTMVT 284 LGA+ VI + + ++ K + L+ VGG + T + L++ + G T VT Sbjct: 225 KLGADDVI---DYKSGSVEEQLKSLKPFDFILDNVGGSTETWAPDFLKKWS-GATYVT 278 >3FBG-A nrPDB Length = 346 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 47/188 (25%), Positives = 81/188 (43%), Gaps = 15/188 (7%) Query: 62 NLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPELPAVGGNEGVAQVVAVGSNVTG 121 NL++ + ++ VK+ + +NP D + + + P V G + + V +VG+ VT Sbjct: 24 NLDIPEPKVHEILVKIQSISVNPVDTKQRLMD---VSKAPRVLGFDAIGVVESVGNEVTM 80 Query: 122 LKPGDWVIPANA--GLGTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYRMLMDF- 178 GD V + + G+ + +E + + P +I + A +L + TAY L D Sbjct: 81 FNQGDIVYYSGSPDQNGSNAEYQLINERLVAKAPKNISAEQAVSLPLTGITAYETLFDVF 140 Query: 179 -----EQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGA 233 G +++ GVG QIA A GLR I I+ K +GA Sbjct: 141 GISRNRNENEGKTLLIINGAGGVGSIATQIAKAYGLRVITTASRNETIE----WTKKMGA 196 Query: 234 EHVITEEE 241 + V+ +E Sbjct: 197 DIVLNHKE 204 >2J3K-A nrPDB Length = 345 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 69/295 (23%), Positives = 126/295 (42%), Gaps = 36/295 (12%) Query: 58 VELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPELPAVGGNEGVAQVVAVGS 117 V +KNL L+ D +++ +PS + Q + P P G GV++++ G Sbjct: 41 VLVKNLYLSC----DPYMRIRMGKPDPSTAALAQA---YTPGQPIQG--YGVSRIIESGH 91 Query: 118 NVTGLKPGD--WVIPANAGLGTWRTEAVFS--EEALIQV-PSDIPLQS-AATLGVNPCTA 171 K GD W G+ W +V + A ++ +D+PL LG+ TA Sbjct: 92 --PDYKKGDLLW------GIVAWEEYSVITPMTHAHFKIQHTDVPLSYYTGLLGMPGMTA 143 Query: 172 YRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSL 231 Y + + G++V +A++ VGQ V Q+A +G + + + L + Sbjct: 144 YAGFYEVCSPKEGETVYVSAASGAVGQLVGQLAKMMGCYVVGSAGSKEKVDLLKTKFGFD 203 Query: 232 GAEHVITEEELRRPEMKNFFKDMPQPRLALNCVGGKSSTELLRQLARGGT-----MVTYG 286 A + E +L + F + + VGGK +L + G M++ Sbjct: 204 DAFNYKEESDLTAALKRCFPNGID---IYFENVGGKMLDAVLVNMNMHGRIAVCGMISQY 260 Query: 287 GMAKQPVVASVSLLIFKDLKLRGFWLSQWKKDHSPDQFKELILTLCDLIRRGQLT 341 + Q V ++S +I+K +++GF +S + +S +F E +L IR G++T Sbjct: 261 NLENQEGVHNLSNIIYKRNRIQGFVVSDFYDKYS--KFLEFVLP---HIREGKIT 310 >1E3E-A nrPDB Length = 376 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 29/89 (32%), Positives = 46/89 (51%), Gaps = 5/89 (5%) Query: 42 RVRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPELP 101 + +A + G P + E+ E++ + +VR++++A + P+DIN L P Sbjct: 8 KCKAAIAWKTGSPLCIEEI---EVSPPKACEVRIQVIATCVCPTDINATDPKKKAL--FP 62 Query: 102 AVGGNEGVAQVVAVGSNVTGLKPGDWVIP 130 V G+E V +VG VT KPGD VIP Sbjct: 63 VVLGHECAGIVESVGPGVTNFKPGDKVIP 91 >1LLU-A nrPDB Length = 342 Score = 45.8 bits (107), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 53/210 (25%), Positives = 89/210 (42%), Gaps = 32/210 (15%) Query: 40 PARVRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPE 99 P ++A V +G P ++ E+K + V VK+ A+ + +D++ +G++ P Sbjct: 4 PQTMKAAVVHAYGAPLRIEEVK---VPLPGPGQVLVKIEASGVCHTDLHAAEGDWPVKPP 60 Query: 100 LPAVGGNEGVAQVVAVGSNVTGLKPGD-----WVIPA----NAGLGTWRT---------- 140 LP + G+EGV V AVGS VT +K GD W+ A L W T Sbjct: 61 LPFIPGHEGVGYVAAVGSGVTRVKEGDRVGIPWLYTACGCCEHCLTGWETLCESQQNTGY 120 Query: 141 -------EAVFSEEALIQV-PSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNAS 192 E V ++ + + P ++ A + T Y+ L +PG V + Sbjct: 121 SVNGGYAEYVLADPNYVGILPKNVEFAEIAPILCAGVTVYKGLKQ-TNARPGQWVAISGI 179 Query: 193 NSGVGQAVIQIAAALGLRTINVVRDRPDIQ 222 G+G +Q A A+GL + D ++ Sbjct: 180 G-GLGHVAVQYARAMGLHVAAIDIDDAKLE 208 >5ENV-A nrPDB Length = 347 Score = 45.4 bits (106), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 44/196 (22%), Positives = 81/196 (41%), Gaps = 32/196 (16%) Query: 46 LVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPELPAVGG 105 + Y HG +E K++ + + +++ + + + + +D++ G++ +LP VGG Sbjct: 10 IFYESHGK----LEYKDIPVPKPKANELLINVKYSGVCHTDLHAWHGDWPLPVKLPLVGG 65 Query: 106 NEGVAQVVAVGSNVTGLKPGD-----WVIPA----------------NAGLGTWRTEAVF 144 +EG VV +G NV G K GD W+ + +A L + + F Sbjct: 66 HEGAGVVVGMGENVKGWKIGDYAGIKWLNGSCMACEYCELGNESNCPHADLSGYTHDGSF 125 Query: 145 SEEAL------IQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQ 198 + A +P L A + T Y+ L L G V + + G+G Sbjct: 126 QQYATADAVQAAHIPQGTDLAQVAPILCAGITVYKALKS-ANLMAGHWVAISGAAGGLGS 184 Query: 199 AVIQIAAALGLRTINV 214 +Q A A+G R + + Sbjct: 185 LAVQYAKAMGYRVLGI 200 >2EER-A nrPDB Length = 347 Score = 45.1 bits (105), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 56/222 (25%), Positives = 89/222 (40%), Gaps = 47/222 (21%) Query: 55 AKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLP-------ELPAVGGNE 107 K ++L+++ + +GS V +K+ AA + SD++M QG +G L +LP G+E Sbjct: 10 GKPLKLEDIPIPKPKGSQVLIKIEAAGVCHSDVHMRQGRFGNLRIVEDLGVKLPVTLGHE 69 Query: 108 GVAQVVAVGSNVTGLKPGDWVIPANAGLGTWRTEA-----VFSEEALIQVPSDIPLQ--- 159 ++ VG V G GD V + W E EE L P + + Sbjct: 70 IAGRIEEVGDEVVGYSKGDLV-----AVNPWEGEGNCYYCRIGEEHLCDSPRWLGINYDG 124 Query: 160 -----------------------SAATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGV 196 AA L + T YR + L P +++ + G+ Sbjct: 125 AYAEYVLVPHYKYLYKLRRLSAVEAAPLTCSGVTTYRAVRK-ASLDPSKTLVVIGAGGGL 183 Query: 197 GQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVIT 238 G IQIA A+ TI V R + + + R GA++VI Sbjct: 184 GTMAIQIAKAVSGATIIGVDVREEALEAAKR---AGADYVIN 222 >2WEK-A nrPDB Length = 341 Score = 45.1 bits (105), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 64/254 (25%), Positives = 102/254 (40%), Gaps = 19/254 (7%) Query: 72 DVRVKMLAAPINPSDINMIQGNYGFLPELPAVGGNEGVAQVVAVGSNVTGLKPGDWVIPA 131 D+ V+ +N SDIN G Y + P G EG+ +VVA+G + + + A Sbjct: 34 DLLVRNRFVGVNASDINYSAGRYDPSVKPPFDIGFEGIGEVVALGLSASARYTVGQAV-A 92 Query: 132 NAGLGTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNA 191 G++ V VPS P TL V+ TAY L + L G V+ A Sbjct: 93 YMAPGSFAEYTVVPASIATPVPSVKP--EYLTLLVSGTTAYISLKELGGLSEGKKVLVTA 150 Query: 192 SNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFF 251 + G GQ +Q++ I + S LKSLG + I + P Sbjct: 151 AAGGTGQFAMQLSKKAKCHVIGTCSS----DEKSAFLKSLGCDRPINYK--TEPVGTVLK 204 Query: 252 KDMPQP-RLALNCVGGKSSTELLRQLARGGTMVTYGGMAK-------QPVVASV--SLLI 301 ++ P+ + VGG + LA G ++ G ++ PV A + L+ Sbjct: 205 QEYPEGVDVVYESVGGAMFDLAVDALATKGRLIVIGFISGYQTPTGLSPVKAGTLPAKLL 264 Query: 302 FKDLKLRGFWLSQW 315 K ++GF+L+ + Sbjct: 265 KKSASVQGFFLNHY 278 >5FI5-A nrPDB Length = 357 Score = 45.1 bits (105), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 50/183 (27%), Positives = 71/183 (38%), Gaps = 28/183 (15%) Query: 28 GPAASSYSASAEPARVRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDI 87 GPA +S S S E V+A D + + N A DV++K+L D Sbjct: 1 GPAMASKSPSEEVYPVKAFGLAAK-DSSGLFSPFNFSRRATGEHDVQLKVLYCGTCQYDR 59 Query: 88 NMIQGNYGFLPELPAVGGNEGVAQVVAVGSNVTGLKPGDWVIPA---------------- 131 M + +GF P V G+E V +V VGS V K GD V A Sbjct: 60 EMSKNKFGFT-SYPYVLGHEIVGEVTEVGSKVQKFKVGDKVGVASIIETCGKCEMCTNEV 118 Query: 132 ----------NAGLGTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQL 181 ++ G AV +E +I+ P ++PL S L TAY + + Sbjct: 119 ENYCPEAGSIDSNYGACSNIAVINENFVIRWPENLPLDSGVPLLCAGITAYSPMKRYGLD 178 Query: 182 QPG 184 +PG Sbjct: 179 KPG 181 >3S2F-A nrPDB Length = 340 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 53/197 (26%), Positives = 83/197 (42%), Gaps = 35/197 (17%) Query: 73 VRVKMLAAPINPSDINMIQGNYGFLPELPAVGGNEGVAQVVAVGSNVTGLKPGD-----W 127 V+VK+ A+ + +D++ G++ P LP + G+EGV V AVGS V+ +K GD W Sbjct: 30 VQVKIEASGVCHTDLHAADGDWPVKPTLPFIPGHEGVGYVSAVGSGVSRVKEGDRVGVPW 89 Query: 128 VIPA----NAGLGTWRT-----------------EAVFSEEALIQ-VPSDIPLQSAATLG 165 + A L W T E V ++ + +P + A + Sbjct: 90 LYSACGYCEHCLQGWETLCEKQQNTGYSVNGGYGEYVVADPNYVGLLPDKVGFVEIAPIL 149 Query: 166 VNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLS 225 T Y+ L +PG V+ + G+G +Q A A+GLR V DI Sbjct: 150 CAGVTVYKGL-KVTDTRPGQWVVISGIG-GLGHVAVQYARAMGLRVAAV-----DIDDAK 202 Query: 226 DRL-KSLGAEHVITEEE 241 L + LGAE + + Sbjct: 203 LNLARRLGAEVAVNARD 219 >1O89-A nrPDB Length = 345 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 62/268 (23%), Positives = 108/268 (40%), Gaps = 24/268 (8%) Query: 53 DPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPELPAVGGNEGVAQV 112 D + ++ L+ + + DV V + + +N D I G + P + G + V Sbjct: 31 DGKTLASVQTLDESRLPEGDVTVDVHWSSLNYKDALAITGKGKIIRNFPMIPGIDFAGTV 90 Query: 113 VAVGSNVTGLKPGDWVIPANAGLGT--W---RTEAVFSEEALIQVPSDIPLQSAATLGVN 167 S G V+ G+G W +A + L+ +P + + A +G Sbjct: 91 RT--SEDPRFHAGQEVLLTGWGVGENHWGGLAEQARVKGDWLVAMPQGLDARKAMIIGTA 148 Query: 168 PCTAYRMLMDFEQL----QPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQK 223 TA +M E Q G+ V+ AS GVG + + LG + + V + Sbjct: 149 GFTAMLCVMALEDAGVRPQDGEIVVTGASG-GVGSTAVALLHKLGYQVVAV----SGRES 203 Query: 224 LSDRLKSLGAEHVITEEEL--RRPEMKNFFKDMPQPRLALNCVGGKSSTELLRQLARGGT 281 + LKSLGA V+ +E RP K + A++ VG K ++L Q+ GG Sbjct: 204 THEYLKSLGASRVLPRDEFAESRPLEKQVWAG------AIDTVGDKVLAKVLAQMNYGGC 257 Query: 282 MVTYGGMAKQPVVASVSLLIFKDLKLRG 309 + G + +V I ++++L+G Sbjct: 258 VAACGLAGGFTLPTTVMPFILRNVRLQG 285 >4RQU-A nrPDB Length = 375 Score = 42.7 bits (99), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 30/93 (32%), Positives = 47/93 (50%), Gaps = 4/93 (4%) Query: 42 RVRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPELP 101 R +A V G P + E+ E+A + +VR+K+L + +D+ + G P P Sbjct: 5 RCKAAVAWEAGKPLVIEEV---EVAPPQKHEVRIKILFTSLCHTDVYFWEAK-GQTPLFP 60 Query: 102 AVGGNEGVAQVVAVGSNVTGLKPGDWVIPANAG 134 + G+E V +VG VT L+PGD V+P G Sbjct: 61 RIFGHEAGGIVESVGEGVTDLQPGDHVLPIFTG 93 >5VKT-A nrPDB Length = 362 Score = 42.7 bits (99), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 50/207 (24%), Positives = 82/207 (39%), Gaps = 41/207 (19%) Query: 71 SDVRVKMLAAPINPSDINMIQGNYGFLPELPAVGGNEGVAQVVAVGSNVTGLKPGDWV-- 128 +DV +K+L I +D+++I+ +G P V G+E V V VG VT K GD V Sbjct: 35 ADVTIKVLFCGICHTDLHVIKNEWGN-AMYPVVPGHEVVGVVTDVGHGVTKFKAGDTVGV 93 Query: 129 ------------------------IPANAGL----------GTWRTEAVFSEEALIQVPS 154 + + G+ G + V S++ +++VP Sbjct: 94 GYFVDSCRTCESCSTGHENYCPDLVLTSNGVDHHHHGATTKGGFSDVLVVSQDFVVRVPE 153 Query: 155 DIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINV 214 +PL AA L T Y + + +PG + AV + A A G+ T+ V Sbjct: 154 SLPLDGAAPLLCAGVTVYSPMAQYALNEPGKHLGVVGLGGLGHMAV-KFAKAFGM-TVTV 211 Query: 215 VRDRPDIQKLSDRLKSLGAEHVITEEE 241 + P K + L LGA+ + + Sbjct: 212 ISSSP--GKRDEALGRLGADAFLVSHD 236 >4DLA-A nrPDB Length = 396 Score = 42.7 bits (99), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 58/244 (23%), Positives = 95/244 (38%), Gaps = 59/244 (24%) Query: 53 DPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPE--LPAVGGNEGVA 110 +P K + ++++++A + +VRVK+L + +D G PE P V G+E Sbjct: 34 EPNKPLVIEDVQVAPPQAGEVRVKVLYTALCHTDAYTWSGKD---PEGLFPCVLGHEAAG 90 Query: 111 QVVAVGSNVTGLKPGDWVIP------------------------ANAGLG---------- 136 V +VG VT ++PGD VIP A G+G Sbjct: 91 IVESVGEGVTEVQPGDHVIPCYQAECRECKFCKSGKTNLCGKVRAATGVGVMMNDRKSRF 150 Query: 137 --------------TWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQ 182 T+ V + ++ ++ PL+ LG T + + +++ Sbjct: 151 SINGKPIYHFMGTSTFSQYTVVHDVSVAKIDPVAPLEKVCLLGCGVPTGLGAVWNTAKVE 210 Query: 183 PGDSVIQNASNSGVGQAVIQIAAALGL-RTINVVRDRPDIQKLSDRLKSLGAEHVITEEE 241 PG S++ VG AV + A A G R I + D K DR K+ G I +E Sbjct: 211 PG-SIVAVFGLGTVGLAVAEGAKAAGASRIIGIDID----SKKFDRAKNFGVTEFINPKE 265 Query: 242 LRRP 245 +P Sbjct: 266 HEQP 269 >3HZZ-A nrPDB Length = 467 Score = 40.8 bits (94), Expect = 9e-04, Method: Compositional matrix adjust. Identities = 43/157 (27%), Positives = 69/157 (43%), Gaps = 16/157 (10%) Query: 105 GNEGVAQVVAV------GSNVTGLKPGDWVIPANAGLGTWRTEAVFSEEALIQVPSDIPL 158 G+E VA ++V G + T L P + G A+ L+ P + Sbjct: 160 GDEVVAHCLSVELESPDGHDDTMLDPEQRIWGFETNFGGLAEIALVKTNQLMPKPKHLTW 219 Query: 159 QSAATLGVNPCTAYRMLM--DFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVR 216 + AA G+ TAYR L+ + ++ GD+V+ ++ G+G Q A A G I VV Sbjct: 220 EEAAAPGLVNSTAYRQLVSRNGAAMKQGDNVLIWGASGGLGSYATQFALAGGANPICVVS 279 Query: 217 DRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFFKD 253 + ++ +S+GAE +I R E F+KD Sbjct: 280 S----PQKAEICRSMGAEAIID----RNAEGYKFWKD 308 >1CDO-A nrPDB Length = 374 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 56/262 (21%), Positives = 99/262 (37%), Gaps = 69/262 (26%) Query: 60 LKNLELAAVRGSDVRVKMLAAPINPSDI-NMIQGNY--GFLPELPAVGGNEGVAQVVAVG 116 ++ +E+ +++R+K++A + +D+ ++ +G + GF P V G+EG V +VG Sbjct: 23 IEEIEVDVPHANEIRIKIIATGVCHTDLYHLFEGKHKDGF----PVVLGHEGAGIVESVG 78 Query: 117 SNVTGLKPGDWVIP------------------------ANA------------------- 133 VT +PG+ VIP AN Sbjct: 79 PGVTEFQPGEKVIPLFISQCGECRFCQSPKTNQCVKGWANESPDVMSPKETRFTCKGRKV 138 Query: 134 ----GLGTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQ 189 G T+ V ++ A+ ++ PL + LG T + ++ +++PG S Sbjct: 139 LQFLGTSTFSQYTVVNQIAVAKIDPSAPLDTVCLLGCGVSTGFGAAVNTAKVEPG-STCA 197 Query: 190 NASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRP---- 245 VG A + + G + I V PD ++ K GA + + P Sbjct: 198 VFGLGAVGLAAVMGCHSAGAKRIIAVDLNPD---KFEKAKVFGATDFVNPNDHSEPISQV 254 Query: 246 --EMKNFFKDMPQPRLALNCVG 265 +M N D +L CVG Sbjct: 255 LSKMTNGGVD-----FSLECVG 271 >4OH1-A nrPDB Length = 351 Score = 39.3 bits (90), Expect = 0.002, Method: Compositional matrix adjust. Identities = 65/261 (24%), Positives = 106/261 (40%), Gaps = 47/261 (18%) Query: 69 RGSDVRVKMLAAPINPSDINMIQGNYGFLPE-----LPAVGGNE--GVAQVVAVGSNVTG 121 + ++R+K++ A I SD +++ GN G + LP G+E GV V + G Sbjct: 32 KDEEIRIKVVYASICGSDTHILTGNLGEMESTTRSMLPMSFGHELSGVIDKVGSTAEKMG 91 Query: 122 LKPGDWVIP--------------------ANAG--LGTWRTEAVFSEEALIQVPSDIPLQ 159 K G V+ +N G + + AV+ + +P D L+ Sbjct: 92 FKVGQKVVANYAKYCGCCENCREGKVNLCSNMGYRMNGFSEYAVYHMSQIFPIPDDADLK 151 Query: 160 SAATLGVNPCTAYRMLMDFEQLQPGDSV-IQNASNSGVGQAVIQIAAALGLRTINVVRDR 218 A V P T + ++ G SV I A G+G ++Q+A G TI V Sbjct: 152 DYAL--VEPLTVALSSAEQAKISYGKSVAIMGA--GGLGMMLVQLARLAGASTITVFDIV 207 Query: 219 PDIQKLSDRLKSLGAEHVITEEE----LRRPEMKNFFKDMPQPRLALNCVGGKSSTEL-L 273 P +KL L++ GA++ + E R E+ D L G ++ +L L Sbjct: 208 P--EKLELALEN-GADYALNSAEEGVAERAIELAGGRYD-----CVLEGTGATAAAKLGL 259 Query: 274 RQLARGGTMVTYGGMAKQPVV 294 + LAR G V + K P++ Sbjct: 260 QLLARDGDAVYFAMYGKDPIL 280 >5TNX-A nrPDB Length = 383 Score = 39.3 bits (90), Expect = 0.003, Method: Compositional matrix adjust. Identities = 61/254 (24%), Positives = 96/254 (37%), Gaps = 76/254 (29%) Query: 37 SAEPARVRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGF 96 S EPAR+RA RG +V V+++A + +D+ +++ Y Sbjct: 31 SIEPARIRA----------------------PRGDEVLVRVVATGLCHTDL-IVRDQYYP 67 Query: 97 LPELPAVGGNEGVAQVVAVGSNVTGLKPGDWVIPANAGLG-------------------- 136 +P LPAV G+EG V AVG NV L GD V+ G Sbjct: 68 VP-LPAVLGHEGAGVVEAVGPNVKTLAAGDHVVLTYGACGHCASCAGGHGAYCRQFFALN 126 Query: 137 ----------------------------TWRTEAVFSEEALIQVPSDIPLQSAATLGVNP 168 ++ + A+ E I+VP + PL+ LG Sbjct: 127 FGGADADGQTALRDAAGEPLHDHFFAQSSFASYALARENNAIKVPKEAPLELLGPLGCGI 186 Query: 169 CTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRL 228 T +++ ++ G S + + VG + + A G TI V P +L+ L Sbjct: 187 QTGAGAVINSLAVRTGSSFASFGAGA-VGMSAVMAARIAGATTIIAVDIVP--SRLALAL 243 Query: 229 KSLGAEHVITEEEL 242 + LGA H I +E+ Sbjct: 244 E-LGATHAINSKEV 256 >1F8F-A nrPDB Length = 371 Score = 38.9 bits (89), Expect = 0.004, Method: Compositional matrix adjust. Identities = 26/71 (36%), Positives = 43/71 (60%), Gaps = 2/71 (2%) Query: 59 ELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPELPAVGGNEGVAQVVAVGSN 118 EL+ L++ +G +V VK++A + +D +I + + LPAV G+EG + A+G N Sbjct: 20 ELQALKIRQPQGDEVLVKVVATGMCHTD--LIVRDQKYPVPLPAVLGHEGSGIIEAIGPN 77 Query: 119 VTGLKPGDWVI 129 VT L+ GD V+ Sbjct: 78 VTELQVGDHVV 88 >5Z0C-A nrPDB Length = 374 Score = 38.1 bits (87), Expect = 0.006, Method: Compositional matrix adjust. Identities = 53/202 (26%), Positives = 72/202 (35%), Gaps = 43/202 (21%) Query: 72 DVRVKMLAAPINPSDINMIQGNYG--FLPELPAVGGNEGVAQVVAVGSNVTGLKPGDWV- 128 DV K+L I SD++ I+ + P LP G+E V +V VGS V K GD V Sbjct: 40 DVTFKVLYCGICHSDLHYIKNEWSNTIYPALP---GHEIVGEVTEVGSKVNKFKVGDKVG 96 Query: 129 ---------------------------------IPANAGLGTWRTEAVFSEEALIQVPSD 155 G + V E +++P Sbjct: 97 VGCIVGSCHSCPNCNNHLENYCPNRILTFGSRYYDGTLNHGGYSDLMVVQEHFAVRIPDA 156 Query: 156 IPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVV 215 +PL SAA L T Y L + +PG V AV + A A G++ + VV Sbjct: 157 LPLDSAAPLLCAGITVYSPLRYYGLDKPGLHVGVVGLGGLGHMAV-KFAKAFGVK-VTVV 214 Query: 216 RDRPDIQKLSDRLKSLGAEHVI 237 P K D + LGA I Sbjct: 215 STSP--AKKEDAISGLGAHSFI 234 >1R37-A nrPDB Length = 347 Score = 37.0 bits (84), Expect = 0.013, Method: Compositional matrix adjust. Identities = 23/67 (34%), Positives = 34/67 (50%), Gaps = 7/67 (10%) Query: 69 RGSDVRVKMLAAPINPSDINMIQGNYGFLP-------ELPAVGGNEGVAQVVAVGSNVTG 121 +G V +K+ AA + SD++M QG +G L +LP G+E ++ VG V G Sbjct: 24 KGPQVLIKVEAAGVCHSDVHMRQGRFGNLRIVEDLGVKLPVTLGHEIAGKIEEVGDEVVG 83 Query: 122 LKPGDWV 128 GD V Sbjct: 84 YSKGDLV 90 >4GKV-A nrPDB Length = 336 Score = 37.0 bits (84), Expect = 0.015, Method: Compositional matrix adjust. Identities = 35/162 (21%), Positives = 67/162 (41%), Gaps = 36/162 (22%) Query: 50 HHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPELPAVGGNEGV 109 HH V++ L +++ + +KM + +D+++ G++G + + G+EG+ Sbjct: 10 HH------VDVTYKTLRSLKHGEALLKMECCGVCHTDLHVKNGDFG--DKTGVILGHEGI 61 Query: 110 AQVVAVGSNVTGLKPGD-----WVIPA-------------------NAGL---GTWRTEA 142 V VG VT LKPGD W NAG G E Sbjct: 62 GVVAEVGPGVTSLKPGDRASVAWFYEGCGHCEYCNSGNETLCRSVKNAGYSVDGGMAEEC 121 Query: 143 VFSEEALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPG 184 + + ++VP + +A+++ T Y+ + +++PG Sbjct: 122 IVVADYAVKVPDGLDSAAASSITCAGVTTYKAV-KLSKIRPG 162 >4JJI-A nrPDB Length = 378 Score = 37.0 bits (84), Expect = 0.015, Method: Compositional matrix adjust. Identities = 24/81 (29%), Positives = 43/81 (53%), Gaps = 5/81 (6%) Query: 53 DPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPE--LPAVGGNEGVA 110 +P K + ++++++A + +VR+K+L + +D G PE P + G+E Sbjct: 16 EPNKPLVIEDVQVAPPQAGEVRIKILYTALCHTDAYTWSGKD---PEGLFPCILGHEAAG 72 Query: 111 QVVAVGSNVTGLKPGDWVIPA 131 V +VG VT ++ GD VIP Sbjct: 73 IVESVGEGVTEVQAGDHVIPC 93 >3B70-A nrPDB Length = 371 Score = 36.6 bits (83), Expect = 0.016, Method: Compositional matrix adjust. Identities = 59/228 (25%), Positives = 88/228 (38%), Gaps = 30/228 (13%) Query: 73 VRVKMLAAPINPSDINM---IQGNYGFLPELPAVGGNEGVAQVVAVGSNVTGLKPGDWVI 129 V V++ A INPSD M + FL G + VVAVGS+VT ++ GD V Sbjct: 39 VYVRVEAVAINPSDTKMRGQFATPWAFL-------GTDYAGTVVAVGSDVTHIQVGDRVY 91 Query: 130 -------PANAGLGTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQ 182 P G + V ++P + + AA L TA + Sbjct: 92 GAQNEMCPRTPDQGAFSQYTVTRGRVWAKIPKGLSFEQAAALPAGISTAGLAMKLLGLPL 151 Query: 183 PGDSVIQNASNSG-VGQAVIQIAAALGLRTINVVRDRPDIQKLS------DRLKSLGAEH 235 P S Q ++S V V + A T+ ++R I + D KS GAE Sbjct: 152 PSPSADQPPTHSKPVYVLVYGGSTATATVTMQMLRLSGYIPIATCSPHNFDLAKSRGAEE 211 Query: 236 VITEEELRRPEMKNFFKDMPQP--RLALNCVGG-KSSTELLRQLARGG 280 V + R P + + + R AL+C+ +S+T + R G Sbjct: 212 VF---DYRAPNLAQTIRTYTKNNLRYALDCITNVESTTFCFAAIGRAG 256 >1PL8-A nrPDB Length = 356 Score = 36.2 bits (82), Expect = 0.022, Method: Compositional matrix adjust. Identities = 32/96 (33%), Positives = 53/96 (55%), Gaps = 7/96 (7%) Query: 35 SASAEPARVRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQ-GN 93 +A+A+P + +V+G GD + L+N + ++V ++M + I SD++ + G Sbjct: 1 AAAAKPNNLSLVVHGP-GD----LRLENYPIPEPGPNEVLLRMHSVGICGSDVHYWEYGR 55 Query: 94 YG-FLPELPAVGGNEGVAQVVAVGSNVTGLKPGDWV 128 G F+ + P V G+E V VGS+V LKPGD V Sbjct: 56 IGNFIVKKPMVLGHEASGTVEKVGSSVKHLKPGDRV 91 >3TWO-A nrPDB Length = 348 Score = 35.8 bits (81), Expect = 0.033, Method: Compositional matrix adjust. Identities = 54/227 (23%), Positives = 81/227 (35%), Gaps = 47/227 (20%) Query: 67 AVRGSDVRVKMLAAPINPSDINMIQGNY--GFLPELPAVGGNEGVAQVVAVGSNVTGLKP 124 AV DV + +L A I SDI+ + G P +P G+E + VG V K Sbjct: 26 AVGPRDVLIDILYAGICHSDIHSAYSEWKEGIYPMIP---GHEIAGIIKEVGKGVKKFKI 82 Query: 125 GD------WVIPANA------------------------------GLGTWRTEAVFSEEA 148 GD +V A +G + V E Sbjct: 83 GDVVGVGCFVNSCKACKPCKEHQEQFCTKVVFTYDCLDSFHDNEPHMGGYSNNIVVDENY 142 Query: 149 LIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALG 208 +I V + PL+ A L T Y L F ++ G V A G+G ++ A A+G Sbjct: 143 VISVDKNAPLEKVAPLLCAGITTYSPL-KFSKVTKGTKV-GVAGFGGLGSMAVKYAVAMG 200 Query: 209 LRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFFKDMP 255 R+ K D L S+G +H T+ + + E+ +P Sbjct: 201 AEVSVFARNE---HKKQDAL-SMGVKHFYTDPKQCKEELDFIISTIP 243 >1KEV-A nrPDB Length = 351 Score = 35.4 bits (80), Expect = 0.038, Method: Compositional matrix adjust. Identities = 40/149 (26%), Positives = 61/149 (40%), Gaps = 35/149 (23%) Query: 72 DVRVKMLAAPINPSDINMI-QGNYGFLPELPAVGGNEGVAQVVAVGSNVTGLKPGDWVI- 129 D V+ LA SDI+ + +G G + + G+E V +VV VGS V KPGD VI Sbjct: 26 DAIVRPLAVSPCTSDIHTVFEGALGDRKNM--ILGHEAVGEVVEVGSEVKDFKPGDRVIV 83 Query: 130 ------------------PANAGLGTWR----TEAVFSEEALIQ--------VPSDIPLQ 159 +N L W+ + VF E + +P D+PL+ Sbjct: 84 PCTTPDWRSLEVQAGFQQHSNGMLAGWKFSNFKDGVFGEYFHVNDADMNLAILPKDMPLE 143 Query: 160 SAATLGVNPCTAYRMLMDFEQLQPGDSVI 188 +A + T + + +Q G SV+ Sbjct: 144 NAVMITDMMTTGFHG-AELADIQMGSSVV 171 >5GXF-A nrPDB Length = 330 Score = 35.0 bits (79), Expect = 0.047, Method: Compositional matrix adjust. Identities = 47/190 (24%), Positives = 72/190 (37%), Gaps = 34/190 (17%) Query: 126 DWVIPANAGLGTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGD 185 DW++P GL T + AV T G A L D L PG Sbjct: 110 DWLVPLPEGLDTRQAMAV------------------GTAGFTAMLAVMALED-HGLTPGH 150 Query: 186 S-VIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEEL-- 242 V+ + GVG I A LG + V RP+ +D L SLGA ++ +E+ Sbjct: 151 GPVLVTGAAGGVGSVATAILAHLGYE-VAAVTGRPET---ADYLTSLGATQIVARDEINE 206 Query: 243 --RRPEMKNFFKDMPQPRLALNCVGGKSSTELLRQLARGGTMVTYGGMAKQPVVASVSLL 300 +RP + ++ VGG +L Q+ G ++ G + A+V Sbjct: 207 TVKRPLESEIWAG------CVDAVGGAMLARVLGQMKYGASVAAVGLAGGAGLPATVIPF 260 Query: 301 IFKDLKLRGF 310 + + + L G Sbjct: 261 LLRGVNLLGI 270 >1UUF-A nrPDB Length = 369 Score = 34.3 bits (77), Expect = 0.090, Method: Compositional matrix adjust. Identities = 19/58 (32%), Positives = 32/58 (55%), Gaps = 1/58 (1%) Query: 71 SDVRVKMLAAPINPSDINMIQGNYGFLPELPAVGGNEGVAQVVAVGSNVTGLKPGDWV 128 +DV++++ + SD++ ++ + P V G+E V +VVAVG V PGD V Sbjct: 48 NDVKIEIAYCGVCHSDLHQVRSEWAGTV-YPCVPGHEIVGRVVAVGDQVEKYAPGDLV 104 >3QE3-A nrPDB Length = 355 Score = 33.5 bits (75), Expect = 0.14, Method: Compositional matrix adjust. Identities = 27/73 (36%), Positives = 40/73 (54%), Gaps = 2/73 (2%) Query: 58 VELKNLELAAVRGSDVRVKMLAAPINPSDINMIQ-GNYG-FLPELPAVGGNEGVAQVVAV 115 + L+N + ++V +KM + I SD++ Q G G F+ + P V G+E VV V Sbjct: 18 LRLENYPIPEPGPNEVLLKMHSVGICGSDVHYWQHGRIGDFVVKKPMVLGHEASGTVVKV 77 Query: 116 GSNVTGLKPGDWV 128 GS V L+PGD V Sbjct: 78 GSLVRHLQPGDRV 90 >3FPL-A nrPDB Length = 351 Score = 33.5 bits (75), Expect = 0.17, Method: Compositional matrix adjust. Identities = 35/125 (28%), Positives = 52/125 (41%), Gaps = 34/125 (27%) Query: 72 DVRVKMLAAPINPSDINMI-QGNYGFLPELPAVGGNEGVAQVVAVGSNVTGLKPGDWVI- 129 D V+ LA SDI+ + +G G + + G+E V +VV VGS V KPGD VI Sbjct: 26 DAIVRPLAVSPCTSDIHTVFEGALGDRKNM--ILGHEAVGEVVEVGSEVKDFKPGDRVIV 83 Query: 130 ------------------PANAGLGTWR----TEAVFSEEALIQ--------VPSDIPLQ 159 +N L W+ + VF E + +P D+PL+ Sbjct: 84 PCTTPDWRSLEVQAGFQQHSNGMLAGWKFSNFKDGVFGEYFHVNDADMNLAILPKDMPLE 143 Query: 160 SAATL 164 +A + Sbjct: 144 NAVMI 148 >4AEC-A nrPDB Length = 430 Score = 32.7 bits (73), Expect = 0.29, Method: Compositional matrix adjust. Identities = 30/87 (34%), Positives = 44/87 (50%), Gaps = 18/87 (20%) Query: 166 VNPCTA------YRMLMDFEQ---LQPGDSVI--QNASNSGVGQAVIQIAAALGLRTINV 214 + PC + Y M+ D EQ + PG SV+ + N+G+G A IAA+ G R I Sbjct: 147 MEPCCSVKDRIGYSMVTDAEQKGFISPGKSVLVEPTSGNTGIGLAF--IAASRGYRLILT 204 Query: 215 VRDRPDIQKLSDR--LKSLGAEHVITE 239 + P + R LK+ GAE V+T+ Sbjct: 205 M---PASMSMERRVLLKAFGAELVLTD 228 >1Q1N-A nrPDB Length = 360 Score = 32.3 bits (72), Expect = 0.32, Method: Compositional matrix adjust. Identities = 49/205 (23%), Positives = 79/205 (38%), Gaps = 42/205 (20%) Query: 72 DVRVKMLAAPINPSDINMIQGNYGFLPELPAVGGNEGVAQVVAVG-SNVTGLKPGD---- 126 D+ +K+ A + SDI+ G++G + ++P V G+E V +VV +G + +GLK G Sbjct: 35 DIDIKIEACGVCGSDIHCAAGHWGNM-KMPLVVGHEIVGKVVKLGPKSNSGLKVGQRVGV 93 Query: 127 ---------------------------WVIPANAGL---GTWRTEAVFSEEALIQVPSDI 156 + P G G + E ++ +P +I Sbjct: 94 GAQVFSCLECDRCKNDNEPYCTKFVTTYSQPYEDGYVSQGGYANYVRVHEHFVVPIPENI 153 Query: 157 PLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVR 216 P AA L T Y L+ PG V + I+ A+G T + R Sbjct: 154 PSHLAAPLLCGGLTVYSPLVR-NGCGPGKKVGIVGLGGIGSMGTL-ISKAMGAETYVISR 211 Query: 217 DRPDIQKLSDRLKSLGAEHVITEEE 241 +K D +K +GA+H I E Sbjct: 212 SS---RKREDAMK-MGADHYIATLE 232 >4OAQ-A nrPDB Length = 367 Score = 32.3 bits (72), Expect = 0.35, Method: Compositional matrix adjust. Identities = 22/70 (31%), Positives = 34/70 (48%) Query: 59 ELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPELPAVGGNEGVAQVVAVGSN 118 +L + E + DV +K + SDI+ + + L V G+E + +V+AVG Sbjct: 24 KLASYERKQINPHDVVLKNEVCGLCYSDIHTLSAGWQPLQRDNLVVGHEIIGEVIAVGDE 83 Query: 119 VTGLKPGDWV 128 VT K GD V Sbjct: 84 VTEFKVGDRV 93 >4Y1B-A nrPDB Length = 425 Score = 32.3 bits (72), Expect = 0.36, Method: Compositional matrix adjust. Identities = 53/232 (22%), Positives = 86/232 (37%), Gaps = 46/232 (19%) Query: 51 HGDPAKVVELKNLELAAVRGSDVRVKMLAAPIN----------PSDINMIQGNYGFLPEL 100 +G P + +++ V V VK++AA +N P D+ + G + Sbjct: 51 YGRPVDAFRTEVVDVPPVGPGQVLVKVMAAGVNYNNVWAALGEPLDVIAARQKQGATEDF 110 Query: 101 PAVGGNEGVAQVVAVGSNVTGLKPGDWVI------------------PANA--------- 133 +GG++ V AVG V LKPG V+ P + Sbjct: 111 -HIGGSDLSGIVWAVGDGVR-LKPGAEVVVLACRWDESAQDIRLGADPVTSSTQRVWGYE 168 Query: 134 -GLGTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYRMLMDFE--QLQPGDSVIQN 190 G++ AV E P + +A+ TAYR L +E ++PGD V+ Sbjct: 169 ENYGSFAQFAVVDEYMCHPKPQRLSWAAASCYMATAATAYRQLFGWEPHTVRPGDPVLIW 228 Query: 191 ASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEEL 242 G+G IQ+ +G + VV ++ + LGA+ I E Sbjct: 229 GGAGGLGSIAIQLVRHVGGIPVAVVSS----EERGEFCMRLGAKGWIDRREF 276 >3FSR-A nrPDB Length = 352 Score = 32.0 bits (71), Expect = 0.39, Method: Compositional matrix adjust. Identities = 42/149 (28%), Positives = 64/149 (42%), Gaps = 35/149 (23%) Query: 72 DVRVKMLAAPINPSDINMI-QGNYGFLPELPAVGGNEGVAQVVAVGSNVTGLKPGD-WVI 129 D V+ LA SDI+ + +G G + + G+E V +VV VGS V KPGD V+ Sbjct: 26 DAIVRPLAVAPCTSDIHTVFEGAIGERHNM--ILGHEAVGEVVEVGSEVKDFKPGDRVVV 83 Query: 130 PA----------------NAG--LGTWR----TEAVFSE--------EALIQVPSDIPLQ 159 PA ++G L W+ + VF E L +P +IPL+ Sbjct: 84 PAITPDWRTSEVQRGYHQHSGGMLAGWKFSNVKDGVFGEFFHVNDADMNLAHLPKEIPLE 143 Query: 160 SAATLGVNPCTAYRMLMDFEQLQPGDSVI 188 +A + T + + +Q G SV+ Sbjct: 144 AAVMIPDMMTTGFHG-AELADIQMGSSVV 171 >1YKF-A nrPDB Length = 352 Score = 32.0 bits (71), Expect = 0.41, Method: Compositional matrix adjust. Identities = 28/73 (38%), Positives = 37/73 (50%), Gaps = 4/73 (5%) Query: 72 DVRVKMLAAPINPSDINMI-QGNYGFLPELPAVGGNEGVAQVVAVGSNVTGLKPGDWVIP 130 D V+ LA SDI+ + +G G + + G+E V +VV VGS V KPGD V+ Sbjct: 26 DAIVRPLAVAPCTSDIHTVFEGAIGERHNM--ILGHEAVGEVVEVGSEVKDFKPGDRVV- 82 Query: 131 ANAGLGTWRTEAV 143 A WRT V Sbjct: 83 VPAITPDWRTSEV 95 >3FPC-A nrPDB Length = 352 Score = 32.0 bits (71), Expect = 0.42, Method: Compositional matrix adjust. Identities = 28/73 (38%), Positives = 37/73 (50%), Gaps = 4/73 (5%) Query: 72 DVRVKMLAAPINPSDINMI-QGNYGFLPELPAVGGNEGVAQVVAVGSNVTGLKPGDWVIP 130 D V+ LA SDI+ + +G G + + G+E V +VV VGS V KPGD V+ Sbjct: 26 DAIVRPLAVAPCTSDIHTVFEGAIGERHNM--ILGHEAVGEVVEVGSEVKDFKPGDRVV- 82 Query: 131 ANAGLGTWRTEAV 143 A WRT V Sbjct: 83 VPAITPDWRTSEV 95 >5H83-A nrPDB Length = 360 Score = 31.6 bits (70), Expect = 0.63, Method: Compositional matrix adjust. Identities = 22/67 (32%), Positives = 31/67 (46%), Gaps = 1/67 (1%) Query: 62 NLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPELPAVGGNEGVAQVVAVGSNVTG 121 N A +DV+ K+L D+ M +G + + P V G+E V V +GS V Sbjct: 31 NFSRRATGENDVQFKVLYCGTCNYDLEMSTNKFG-MTKYPFVIGHEIVGVVTEIGSKVQK 89 Query: 122 LKPGDWV 128 K GD V Sbjct: 90 FKVGDKV 96 >2DFV-A nrPDB Length = 347 Score = 31.2 bits (69), Expect = 0.73, Method: Compositional matrix adjust. Identities = 21/77 (27%), Positives = 40/77 (51%), Gaps = 2/77 (2%) Query: 54 PAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPEL--PAVGGNEGVAQ 111 P EL +++ +V +K+LA I +D+++ + N + P + G+E + Sbjct: 12 PGYGAELVEVDVPKPGPGEVLIKVLATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGE 71 Query: 112 VVAVGSNVTGLKPGDWV 128 VV +G V G++ GD+V Sbjct: 72 VVEIGPGVEGIEVGDYV 88 >1E3J-A nrPDB Length = 352 Score = 31.2 bits (69), Expect = 0.80, Method: Compositional matrix adjust. Identities = 21/62 (33%), Positives = 31/62 (50%), Gaps = 2/62 (3%) Query: 69 RGSDVRVKMLAAPINPSDINMIQGNY--GFLPELPAVGGNEGVAQVVAVGSNVTGLKPGD 126 + +V ++M I SD++ + F+ + P V G+E VV VG NV LK GD Sbjct: 27 KEDEVLLQMAYVGICGSDVHYYEHGRIADFIVKDPMVIGHEASGTVVKVGKNVKHLKKGD 86 Query: 127 WV 128 V Sbjct: 87 RV 88 >3GFB-A nrPDB Length = 350 Score = 31.2 bits (69), Expect = 0.84, Method: Compositional matrix adjust. Identities = 22/77 (28%), Positives = 40/77 (51%), Gaps = 2/77 (2%) Query: 54 PAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPEL--PAVGGNEGVAQ 111 PA EL +++ +V +K+LA I +D+++ + N + P + G+E + Sbjct: 13 PAYGAELVEVDVPKPGPGEVLIKVLATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGE 72 Query: 112 VVAVGSNVTGLKPGDWV 128 VV VG V L+ GD++ Sbjct: 73 VVEVGPGVEDLQVGDYI 89 >2OUI-A nrPDB Length = 360 Score = 31.2 bits (69), Expect = 0.85, Method: Compositional matrix adjust. Identities = 36/114 (31%), Positives = 49/114 (42%), Gaps = 32/114 (28%) Query: 105 GNEGVAQVVAVGSNVTGLKPGDWVI-----------------PANAG--LGTWR----TE 141 G+E V Q+V VGS V LK GD VI P ++G LG W+ + Sbjct: 58 GHEAVGQIVKVGSLVKRLKVGDKVIVPAITPDWGEEESQRGYPMHSGGMLGGWKFSNFKD 117 Query: 142 AVFSE-----EA---LIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSV 187 VFSE EA L +P DI + A L T + + ++ GD+V Sbjct: 118 GVFSEVFHVNEADANLALLPRDIKPEDAVMLSDMVTTGFHG-AELANIKLGDTV 170 >5YLN-A nrPDB Length = 356 Score = 30.8 bits (68), Expect = 1.0, Method: Compositional matrix adjust. Identities = 18/61 (29%), Positives = 35/61 (57%), Gaps = 5/61 (8%) Query: 71 SDVRVKMLAAPINPSDINMIQGNYGFLPELPA--VGGNEGVAQVVAVGSNVTGLKPGDWV 128 +D V+++ I +D+++I+G+ +P + + G+EG+ V VG V+ K GD V Sbjct: 30 TDAIVRIVKTTICGTDLHIIKGD---VPTCQSGTILGHEGIGIVEEVGEGVSNFKKGDKV 86 Query: 129 I 129 + Sbjct: 87 L 87 >3V8B-A nrPDB Length = 283 Score = 30.4 bits (67), Expect = 1.3, Method: Compositional matrix adjust. Identities = 17/74 (22%), Positives = 38/74 (51%), Gaps = 1/74 (1%) Query: 182 QPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEE 241 QP + + SG+G+A AA G+ + R R ++++++D + G + + E + Sbjct: 26 QPSPVALITGAGSGIGRATALALAADGVTVGALGRTRTEVEEVADEIVGAGGQAIALEAD 85 Query: 242 LRRP-EMKNFFKDM 254 + +M+N +D+ Sbjct: 86 VSDELQMRNAVRDL 99 >5VM2-A nrPDB Length = 347 Score = 29.6 bits (65), Expect = 2.0, Method: Compositional matrix adjust. Identities = 23/68 (33%), Positives = 34/68 (50%), Gaps = 3/68 (4%) Query: 64 ELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPELP--AVG-GNEGVAQVVAVGSNVT 120 E+ + +V +K+ I SD++ + P+ P +G G+E VVAVGS V Sbjct: 20 EIPVPKEDEVLIKVEYVGICGSDVHGFESGPFIPPKDPNQEIGLGHECAGTVVAVGSRVR 79 Query: 121 GLKPGDWV 128 KPGD V Sbjct: 80 KFKPGDRV 87 >3DWF-A nrPDB Length = 276 Score = 29.6 bits (65), Expect = 2.1, Method: Compositional matrix adjust. Identities = 17/55 (30%), Positives = 27/55 (49%), Gaps = 1/55 (1%) Query: 179 EQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGA 233 E LQ G VI ++ G+G+ + A +G + R + +QK+ R LGA Sbjct: 7 EMLQ-GKKVIVTGASKGIGREIAYHLAKMGAHVVVTARSKEALQKVVARCLELGA 60 >2EFY-A nrPDB Length = 304 Score = 29.6 bits (65), Expect = 2.2, Method: Compositional matrix adjust. Identities = 30/91 (32%), Positives = 47/91 (51%), Gaps = 15/91 (16%) Query: 165 GVNPCT------AYRMLMDFEQ---LQPGDS---VIQNASNSGVGQAVIQIAAALGLRTI 212 G+NP A+ M+ D E+ L+PG V + N+G+G A+I AA+ G R I Sbjct: 32 GLNPGGSIKDRPAWYMIKDAEERGILRPGSGQVIVEPTSGNTGIGLAMI--AASRGYRLI 89 Query: 213 NVVRDRPDIQKLSDRLKSLGAEHVITEEELR 243 + + ++ LK+ GAE V+T+ E R Sbjct: 90 LTMPAQMSEER-KRVLKAFGAELVLTDPERR 119 >2YXE-A nrPDB Length = 215 Score = 29.6 bits (65), Expect = 2.5, Method: Compositional matrix adjust. Identities = 32/131 (24%), Positives = 58/131 (44%), Gaps = 7/131 (5%) Query: 155 DIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINV 214 D PL+ ++ M+ + L+PG V++ + G AV A +G + V Sbjct: 49 DTPLEIGYGQTISAIHMVGMMCELLDLKPGMKVLEIGTGCGYHAAVT--AEIVGEDGLVV 106 Query: 215 VRDR-PDIQKLSDR-LKSLGAEHVITEEELRRPEMKNFFKDMPQPRLALNCVGGKSSTEL 272 +R P++ + ++R L+ LG ++VI + + P R+ G K L Sbjct: 107 SIERIPELAEKAERTLRKLGYDNVIV---IVGDGTLGYEPLAPYDRIYTTAAGPKIPEPL 163 Query: 273 LRQLARGGTMV 283 +RQL GG ++ Sbjct: 164 IRQLKDGGKLL 174 >6FG0-A nrPDB Length = 352 Score = 29.3 bits (64), Expect = 2.6, Method: Compositional matrix adjust. Identities = 20/59 (33%), Positives = 30/59 (50%), Gaps = 1/59 (1%) Query: 71 SDVRVKMLAAPINPSDINMIQGNYG-FLPELPAVGGNEGVAQVVAVGSNVTGLKPGDWV 128 ++ +K+ AA + SDI ++ + LP G+EGV V +G VTG GD V Sbjct: 26 GEILLKVTAAGLCHSDITVMDMPAAQYAGGLPLTLGHEGVGTVAELGEGVTGFGVGDAV 84 >6C49-A nrPDB Length = 350 Score = 29.3 bits (64), Expect = 2.8, Method: Compositional matrix adjust. Identities = 22/70 (31%), Positives = 36/70 (51%), Gaps = 7/70 (10%) Query: 73 VRVKMLAAPINPSDINMIQGNYGFLPELPAVGGNEGVAQVVAVGSNVTGLKPGDWVIPAN 132 V VK+ + SDI+++ + P V G+E + ++VA+GS GL+ G V Sbjct: 41 VEVKVEYCGLCHSDISVLNNEW-HSTVYPVVAGHEIIGRIVALGSEAKGLQIGQRV---- 95 Query: 133 AGLGTWRTEA 142 G+G W E+ Sbjct: 96 -GIG-WTAES 103 >1EVJ-A nrPDB Length = 352 Score = 28.1 bits (61), Expect = 6.3, Method: Compositional matrix adjust. Identities = 19/58 (32%), Positives = 26/58 (44%), Gaps = 9/58 (15%) Query: 13 PARQWR--------GLLPASGCHGPAASSYSASAEPARVRALVYGHHGDPAKVVELKN 62 PA+QWR G L G +G + Y EP VRA Y D + VE+++ Sbjct: 166 PAQQWRLRRELAGGGSLMDIGIYGLNGTRYLLGEEPIEVRAYTYSDPNDE-RFVEVED 222 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 2VCY-A nrPDB 436 e-123 3JYN-A nrPDB 266 1e-71 1QOR-A nrPDB 265 3e-71 3QWB-A nrPDB 256 1e-68 1WLY-A nrPDB 255 2e-68 5LB9-A nrPDB 247 5e-66 4EYE-A nrPDB 244 5e-65 1YB5-A nrPDB 241 3e-64 3PII-A nrPDB 235 2e-62 3MEQ-A nrPDB 235 3e-62 4J6F-A nrPDB 232 2e-61 5K1S-A nrPDB 231 3e-61 4Z6K-A nrPDB 230 1e-60 1LLU-A nrPDB 226 1e-59 5YAT-A nrPDB 223 1e-58 2OBY-A nrPDB 222 2e-58 4A27-A nrPDB 221 5e-58 3TQH-A nrPDB 220 6e-58 6N7L-A nrPDB 218 4e-57 4RVS-A nrPDB 216 1e-56 3S2F-A nrPDB 215 3e-56 3COS-A nrPDB 215 3e-56 3UOG-A nrPDB 208 4e-54 5ENV-A nrPDB 208 4e-54 1U3W-A nrPDB 198 2e-51 1HSO-A nrPDB 197 6e-51 2EER-A nrPDB 195 2e-50 2WEK-A nrPDB 194 5e-50 1HSZ-A nrPDB 194 5e-50 1V3V-A nrPDB 192 3e-49 1H2B-A nrPDB 191 6e-49 2VN8-A nrPDB 189 1e-48 1E3E-A nrPDB 189 2e-48 1MC5-A nrPDB 189 2e-48 5A3V-A nrPDB 186 1e-47 1EE2-A nrPDB 185 2e-47 1O89-A nrPDB 184 4e-47 1D1T-A nrPDB 184 5e-47 2J3K-A nrPDB 183 1e-46 4RQU-A nrPDB 183 2e-46 4DLA-A nrPDB 182 3e-46 1CDO-A nrPDB 181 4e-46 3FBG-A nrPDB 177 6e-45 5FI5-A nrPDB 176 2e-44 1P0F-A nrPDB 174 5e-44 3SLK-A nrPDB 174 7e-44 4UEJ-A nrPDB 173 1e-43 3HZZ-A nrPDB 170 8e-43 2Y05-A nrPDB 167 8e-42 4IDE-A nrPDB 166 1e-41 4CPD-A nrPDB 165 3e-41 4DVJ-A nrPDB 164 8e-41 1YQX-A nrPDB 163 1e-40 5VKT-A nrPDB 151 4e-37 Sequences not found previously or not previously below threshold: 4EEZ-A nrPDB 175 3e-44 4JJI-A nrPDB 173 1e-43 1R37-A nrPDB 167 7e-42 3GFB-A nrPDB 156 1e-38 2DFV-A nrPDB 154 4e-38 4A10-A nrPDB 154 6e-38 4GKV-A nrPDB 152 2e-37 5Z0C-A nrPDB 149 1e-36 1UUF-A nrPDB 149 2e-36 1F8F-A nrPDB 146 1e-35 2H6E-A nrPDB 144 5e-35 5VM2-A nrPDB 143 9e-35 5TNX-A nrPDB 142 2e-34 4Y1B-A nrPDB 139 2e-33 4OH1-A nrPDB 137 7e-33 1PL8-A nrPDB 137 9e-33 5GXF-A nrPDB 136 2e-32 4EJ6-A nrPDB 134 6e-32 5H82-A nrPDB 134 7e-32 1E3J-A nrPDB 130 1e-30 3TWO-A nrPDB 129 3e-30 3QE3-A nrPDB 128 3e-30 5KIA-A nrPDB 128 4e-30 5H83-A nrPDB 127 6e-30 4OAQ-A nrPDB 127 1e-29 6FG0-A nrPDB 126 2e-29 4ILK-A nrPDB 126 2e-29 5YLN-A nrPDB 122 3e-28 2DQ4-A nrPDB 121 6e-28 6C49-A nrPDB 120 8e-28 1Q1N-A nrPDB 117 1e-26 3FSR-A nrPDB 117 1e-26 1KEV-A nrPDB 116 2e-26 2VNA-A nrPDB 115 2e-26 3FPC-A nrPDB 114 5e-26 2CF5-A nrPDB 114 7e-26 1YKF-A nrPDB 114 9e-26 3WLE-A nrPDB 113 1e-25 3FPL-A nrPDB 113 1e-25 3B70-A nrPDB 111 5e-25 2ZB3-A nrPDB 110 6e-25 3IP1-A nrPDB 108 4e-24 2OUI-A nrPDB 100 1e-21 3M6I-A nrPDB 98 5e-21 6DKH-A nrPDB 91 7e-19 2VWH-A nrPDB 72 4e-13 4JLW-A nrPDB 71 1e-12 1KOL-A nrPDB 67 1e-11 2DPH-A nrPDB 63 2e-10 3WID-A nrPDB 50 1e-06 2CDC-A nrPDB 50 2e-06 1Q7C-A nrPDB 46 2e-05 3RSH-A nrPDB 45 4e-05 3VZS-A nrPDB 44 8e-05 3DWF-A nrPDB 44 2e-04 3EZL-A nrPDB 42 5e-04 2UVD-A nrPDB 42 6e-04 3F9I-A nrPDB 41 7e-04 5PGZ-A nrPDB 41 8e-04 4BO1-A nrPDB 40 0.001 3EMK-A nrPDB 40 0.002 5CDY-A nrPDB 39 0.002 3D3W-A nrPDB 39 0.003 5JJC-A nrPDB 39 0.004 4M8S-A nrPDB 39 0.004 1AHH-A nrPDB 38 0.006 2B4Q-A nrPDB 38 0.006 3OSU-A nrPDB 38 0.006 1GEE-A nrPDB 38 0.006 3GRP-A nrPDB 38 0.007 3RKU-A nrPDB 37 0.011 5ILO-A nrPDB 37 0.011 3LYL-A nrPDB 37 0.017 2C07-A nrPDB 36 0.022 3IYF-A nrPDB 36 0.031 4AEC-A nrPDB 35 0.034 4F86-A nrPDB 35 0.041 1V9L-A nrPDB 35 0.059 3T4P-A nrPDB 35 0.059 3WOH-A nrPDB 35 0.061 5IJZ-A nrPDB 35 0.062 1XDW-A nrPDB 35 0.069 3WTC-A nrPDB 35 0.074 1HXH-A nrPDB 34 0.083 1AE1-A nrPDB 34 0.094 2HQ1-A nrPDB 34 0.098 5TQV-A nrPDB 34 0.10 2PNF-A nrPDB 34 0.11 4IS3-A nrPDB 34 0.13 1CYD-A nrPDB 34 0.15 5T5Q-A nrPDB 34 0.17 4FHN-X nrPDB 33 0.18 5YSS-A nrPDB 33 0.20 4R1U-A nrPDB 33 0.26 3FTP-A nrPDB 33 0.27 5OJG-A nrPDB 33 0.28 2YFH-A nrPDB 32 0.30 4XIJ-A nrPDB 32 0.31 4LK4-A nrPDB 32 0.32 3PWS-A nrPDB 32 0.34 2AS0-A nrPDB 32 0.38 4CQM-B nrPDB 32 0.38 5ITV-A nrPDB 32 0.41 4FC7-A nrPDB 32 0.42 3PPI-A nrPDB 32 0.46 4INE-A nrPDB 32 0.47 4IIN-A nrPDB 32 0.48 4AVY-A nrPDB 32 0.51 5BP7-A nrPDB 32 0.53 6GBN-A nrPDB 32 0.60 4QUK-A nrPDB 31 0.68 2ISQ-A nrPDB 31 0.75 3CJR-A nrPDB 31 0.80 4OMU-A nrPDB 31 0.88 1NKV-A nrPDB 31 0.94 3WYE-A nrPDB 31 0.95 4LAT-A nrPDB 31 0.98 5TC4-A nrPDB 31 1.0 6NRP-A nrPDB 30 1.1 4ER3-A nrPDB 30 1.1 3UWP-A nrPDB 30 1.1 1YXM-A nrPDB 30 1.2 1BDB-A nrPDB 30 1.4 6CU3-A nrPDB 30 1.4 3UF0-A nrPDB 30 1.5 3RUW-A nrPDB 30 1.7 3R75-A nrPDB 30 1.7 1URG-A nrPDB 30 1.8 4R1T-A nrPDB 30 1.8 2Q2Q-A nrPDB 30 1.9 1DB3-A nrPDB 30 1.9 1GEG-A nrPDB 30 2.0 1DOH-A nrPDB 30 2.0 2NNL-D nrPDB 30 2.0 6DXF-A nrPDB 30 2.1 6ACF-A nrPDB 29 2.5 3NJ4-A nrPDB 29 2.5 3RWB-A nrPDB 29 2.6 1P77-A nrPDB 29 2.6 6GCS-A nrPDB 29 2.7 1J49-A nrPDB 29 2.8 2AE2-A nrPDB 29 3.0 3L07-A nrPDB 29 3.2 1E3W-A nrPDB 29 3.3 2CDH-G nrPDB 29 4.0 4DIO-A nrPDB 29 4.0 3GIQ-A nrPDB 29 4.2 4PDS-A nrPDB 29 5.0 3WNV-A nrPDB 28 5.4 4EUF-A nrPDB 28 5.7 1F14-A nrPDB 28 5.7 2VHY-A nrPDB 28 5.9 3V8B-A nrPDB 28 6.0 4K6F-A nrPDB 28 6.1 6DEB-A nrPDB 28 6.7 1UZM-A nrPDB 28 6.7 4DFE-A nrPDB 28 6.7 4P80-A nrPDB 28 7.1 4RZI-B nrPDB 28 7.4 2O23-A nrPDB 28 7.7 3FCA-A nrPDB 28 7.9 3DC2-A nrPDB 27 9.2 1DIH-A nrPDB 27 9.9 >2VCY-A nrPDB Length = 344 Score = 436 bits (1120), Expect = e-123, Method: Composition-based stats. Identities = 342/343 (99%), Positives = 342/343 (99%) Query: 31 ASSYSASAEPARVRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMI 90 ASSYSASAEPARVRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMI Sbjct: 2 ASSYSASAEPARVRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMI 61 Query: 91 QGNYGFLPELPAVGGNEGVAQVVAVGSNVTGLKPGDWVIPANAGLGTWRTEAVFSEEALI 150 QGNYG LPELPAVGGNEGVAQVVAVGSNVTGLKPGDWVIPANAGLGTWRTEAVFSEEALI Sbjct: 62 QGNYGLLPELPAVGGNEGVAQVVAVGSNVTGLKPGDWVIPANAGLGTWRTEAVFSEEALI 121 Query: 151 QVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLR 210 QVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLR Sbjct: 122 QVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLR 181 Query: 211 TINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFFKDMPQPRLALNCVGGKSST 270 TINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFFKDMPQPRLALNCVGGKSST Sbjct: 182 TINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFFKDMPQPRLALNCVGGKSST 241 Query: 271 ELLRQLARGGTMVTYGGMAKQPVVASVSLLIFKDLKLRGFWLSQWKKDHSPDQFKELILT 330 ELLRQLARGGTMVTYGGMAKQPVVASVSLLIFKDLKLRGFWLSQWKKDHSPDQFKELILT Sbjct: 242 ELLRQLARGGTMVTYGGMAKQPVVASVSLLIFKDLKLRGFWLSQWKKDHSPDQFKELILT 301 Query: 331 LCDLIRRGQLTAPACSQVPLQDYQSALEASMKPFISSKQILTM 373 LCDLIRRGQLTAPACSQVPLQDYQSALEASMKPFISSKQILTM Sbjct: 302 LCDLIRRGQLTAPACSQVPLQDYQSALEASMKPFISSKQILTM 344 >3JYN-A nrPDB Length = 325 Score = 266 bits (680), Expect = 1e-71, Method: Composition-based stats. Identities = 80/330 (24%), Positives = 133/330 (40%), Gaps = 9/330 (2%) Query: 44 RALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPELPAV 103 + + + G P +V+E + E A V V+ A +N D G Y P LP+ Sbjct: 3 KRIQFSTVGGP-EVLEYVDFEPEAPGPQAVVVRNKAIGLNFIDTYYRSGLYPA-PFLPSG 60 Query: 104 GGNEGVAQVVAVGSNVTGLKPGDWVIPANAGLGTWRTEAVFSEEALIQVPSDIPLQSAAT 163 G EG V AVG VT K GD V LG + V E L+++ + + AA Sbjct: 61 LGAEGAGVVEAVGDEVTRFKVGDRVAYGTGPLGAYSEVHVLPEANLVKLADSVSFEQAAA 120 Query: 164 LGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQK 223 L + T +L Q++PG+ ++ +A+ GVG Q A ALG + I V + Sbjct: 121 LMLKGLTVQYLLRQTYQVKPGEIILFHAAAGGVGSLACQWAKALGAKLIGTVSS----PE 176 Query: 224 LSDRLKSLGAEHVITEEELRRPEMKNFFKDMPQPRLALNCVGGKSSTELLRQLARGGTMV 283 + K+LGA I + D + + + VG + L +A G +V Sbjct: 177 KAAHAKALGAWETIDYSHEDVAKRVLELTDGKKCPVVYDGVGQDTWLTSLDSVAPRGLVV 236 Query: 284 TYGGMAKQPVVASVSLLIFKD-LKLRGFWLSQWKKDHSPDQFKELILTLCDLIRRGQLTA 342 ++G + ++ +L KD + + L + ++ + + L D++ G+L Sbjct: 237 SFGNASGPVSGVNLGILAQKDSVYVTRPTLGSYA--NNAQNLQTMADELFDMLASGKLKV 294 Query: 343 PACSQVPLQDYQSALEASMKPFISSKQILT 372 Q L+D A + IL Sbjct: 295 DGIEQYALKDAAKAQIELSARRTTGSTILI 324 >1QOR-A nrPDB Length = 327 Score = 265 bits (676), Expect = 3e-71, Method: Composition-based stats. Identities = 84/314 (26%), Positives = 131/314 (41%), Gaps = 11/314 (3%) Query: 48 YGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPELPAVGGNE 107 + HG P +V++ A ++++V+ A IN D + G Y P LP+ G E Sbjct: 7 FHKHGGP-EVLQAVEFTPADPAENEIQVENKAIGINFIDTYIRSGLYP-PPSLPSGLGTE 64 Query: 108 GVAQVVAVGSNVTGLKPGDWVIPANAGLGTWRTEAVFSEEALIQVPSDIPLQSAATLGVN 167 V VGS V +K GD V+ A + LG + + + +P+ I + AA + Sbjct: 65 AAGIVSKVGSGVKHIKAGDRVVYAQSALGAYSSVHNIIADKAAILPAAISFEQAAASFLK 124 Query: 168 PCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDR 227 T Y +L +++P + + +A+ GVG Q A ALG + I V QK Sbjct: 125 GLTVYYLLRKTYEIKPDEQFLFHAAAGGVGLIACQWAKALGAKLIGTVGT---AQKAQSA 181 Query: 228 LKSLGAEHVITEEELRRPEMKNFFKDMPQPRLALNCVGGKSSTELLRQLARGGTMVTYGG 287 LK+ GA VI E E + R+ + VG + L L R G MV++G Sbjct: 182 LKA-GAWQVINYREEDLVERLKEITGGKKVRVVYDSVGRDTWERSLDCLQRRGLMVSFGN 240 Query: 288 MAKQPVVASVSLLIFK-DLKLRGFWLSQWKKDHSPDQFKELILTLCDLIRRGQLTAPACS 346 + ++ +L K L + L + ++ E L LI G + Sbjct: 241 SSGAVTGVNLGILNQKGSLYVTRPSLQGYITT--REELTEASNELFSLIASGVIKVDVAE 298 Query: 347 Q--VPLQDYQSALE 358 Q PL+D Q A E Sbjct: 299 QQKYPLKDAQRAHE 312 >3QWB-A nrPDB Length = 334 Score = 256 bits (654), Expect = 1e-68, Method: Composition-based stats. Identities = 71/336 (21%), Positives = 132/336 (39%), Gaps = 15/336 (4%) Query: 40 PARVRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPE 99 P + + ++ G V++ ++ + ++ ++ +K +N + +G Y E Sbjct: 6 PEQQKVILIDEIGG-YDVIKYEDYPVPSISEEELLIKNKYTGVNYIESYFRKGIYPC--E 62 Query: 100 LPAVGGNEGVAQVVAVGSNVTGLKPGDWVIPANAGLGTWRTEA-VFSEEALIQVPSDIPL 158 P V G E VVA G VT + GD V A T+ + + S+ ++++P Sbjct: 63 KPYVLGREASGTVVAKGKGVTNFEVGDQV--AYISNSTFAQYSKISSQGPVMKLPKGTSD 120 Query: 159 QS---AATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVV 215 + A + TA + ++ GD V+ A+ GVG + Q+ G TI V Sbjct: 121 EELKLYAAGLLQVLTALSFTNEAYHVKKGDYVLLFAAAGGVGLILNQLLKMKGAHTIAVA 180 Query: 216 RDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFFKDMPQPRLALNCVGGKSSTELLRQ 275 ++ K GAE++I + F + + + VG + L Sbjct: 181 STDEKLK----IAKEYGAEYLINASKEDILRQVLKFTNGKGVDASFDSVGKDTFEISLAA 236 Query: 276 LARGGTMVTYGGMAKQPVVASVSLLIFKDLKLRGFWLSQWKKDHSPDQFKELILTLCDLI 335 L R G V++G + S++ L K++ L L + D P+++K L+ Sbjct: 237 LKRKGVFVSFGNASGLIPPFSITRLSPKNITLVRPQLYGYIAD--PEEWKYYSDEFFGLV 294 Query: 336 RRGQLTAPACSQVPLQDYQSALEASMKPFISSKQIL 371 +L PL+DY++A K +L Sbjct: 295 NSKKLNIKIYKTYPLRDYRTAAADIESRKTVGKLVL 330 >1WLY-A nrPDB Length = 333 Score = 255 bits (651), Expect = 2e-68, Method: Composition-based stats. Identities = 76/322 (23%), Positives = 128/322 (39%), Gaps = 17/322 (5%) Query: 45 ALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLP--ELPA 102 A V G P V + +++ + VR++ A +N D G L E P Sbjct: 4 AAVIHKKGGPDNFV-WEEVKVGSPGPGQVRLRNTAIGVNFLDTYHRAGIPHPLVVGEPPI 62 Query: 103 VGGNEGVAQVVAVGSNVTGLKPGDWVIPANAGLGTWRTEAVFSEEALIQVPSDIPLQSA- 161 V G E A V VG VT G+ V LG + E ++ E LI+VP D+ L Sbjct: 63 VVGFEAAAVVEEVGPGVTDFTVGERVCTCLPPLGAYSQERLYPAEKLIKVPKDLDLDDVH 122 Query: 162 -ATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPD 220 A L + TA +L +++PGD V+ +A+ G+G ++ A LG I V Sbjct: 123 LAGLMLKGMTAQYLLHQTHKVKPGDYVLIHAAAGGMGHIMVPWARHLGATVIGTVST--- 179 Query: 221 IQKLSDRLKSLGAEHVITEEELRRPEMKNFFKDMPQPRLALNCVGGKSSTELLRQLARGG 280 ++ ++ + LG H I E+ + + +G + + L L G Sbjct: 180 -EEKAETARKLGCHHTINYSTQDFAEVVREITGGKGVDVVYDSIGKDTLQKSLDCLRPRG 238 Query: 281 TMVTYGGMAKQPVVASVSLLIFKDLKLRGFWL----SQWKKDHSPDQFKELILTLCDLIR 336 YG + + + + +DL +RG + W + + E L D ++ Sbjct: 239 MCAAYGHASG----VADPIRVVEDLGVRGSLFITRPALWHYMSNRSEIDEGSKCLFDAVK 294 Query: 337 RGQLTAPACSQVPLQDYQSALE 358 G L + PL++ +A + Sbjct: 295 AGVLHSSVAKTFPLREAAAAHK 316 >5LB9-A nrPDB Length = 385 Score = 247 bits (631), Expect = 5e-66, Method: Composition-based stats. Identities = 136/363 (37%), Positives = 199/363 (54%), Gaps = 44/363 (12%) Query: 41 ARVRALVYGHHGDPAKVVELKNLELA--AVRGSDVRVKMLAAPINPSDINMIQGNYGFLP 98 +A++Y HG+P V+ ++ E+ + ++V VK L +P+NPSDIN IQG Y P Sbjct: 23 ITAQAVLYTQHGEPKDVLFTQSFEIDDDNLAPNEVIVKTLGSPVNPSDINQIQGVYPSKP 82 Query: 99 --------ELPAVG-GNEGVAQVVAVGSNVTGLKPGDWVIPANAGLGTWRTEAVFSEEAL 149 PA GNEG+ +V+ VGSNV+ L+ GDWVIP++ GTWRT A+ +++ Sbjct: 83 AKTTGFGTTEPAAPCGNEGLFEVIKVGSNVSSLEAGDWVIPSHVNFGTWRTHALGNDDDF 142 Query: 150 IQVPS-----------DIPLQSAATLGVNPCTAYRMLMDFEQLQPG-DSVIQNASNSGVG 197 I++P+ + + AT+ VNP AY ML + +L PG D IQN S VG Sbjct: 143 IKLPNPAQSKANGKPNGLTINQGATISVNPLVAYLMLTHYVKLTPGKDWFIQNGGTSAVG 202 Query: 198 QAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRR----PEMKNFFKD 253 + QI L +I+V+RDRP++ ++ LK LGA VITE++ P +K + K Sbjct: 203 KYASQIGKLLNFNSISVIRDRPNLDEVVASLKELGATQVITEDQNNSREFGPTIKEWIKQ 262 Query: 254 -MPQPRLALNCVGGKSSTELLRQLARGGTMVTYGGMAKQPVVASVSLLIFKDLKLRGFWL 312 + +LALNCVGGKSST + R+L G M+TYGGM+ QPV SL IFK+ GFW+ Sbjct: 263 SGGEAKLALNCVGGKSSTGIARKLNNNGLMLTYGGMSFQPVTIPTSLYIFKNFTSAGFWV 322 Query: 313 SQWKKDHSPDQFKELILTLCDLI----RRGQLT-APACSQV-----PLQD-YQSALEASM 361 ++ K++ KEL + + I G+LT A + + PL + YQ + S Sbjct: 323 TELLKNN-----KELKTSTLNQIIAWYEEGKLTDAKSIETLYDGTKPLHELYQDGVANSK 377 Query: 362 KPF 364 Sbjct: 378 DGK 380 >4EYE-A nrPDB Length = 342 Score = 244 bits (622), Expect = 5e-65, Method: Composition-based stats. Identities = 81/333 (24%), Positives = 143/333 (42%), Gaps = 10/333 (3%) Query: 40 PARVRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPE 99 P ++A+ P +V ++E + V V + AA + D M +G Y E Sbjct: 19 PGSMKAIQAQSLSGPEGLV-YTDVETPGAGPNVVVVDVKAAGVCFPDYLMTKGEYQLKME 77 Query: 100 LPAVGGNEGVAQVVAVGSNVTGLKPGDWVIPANAGLGTWRTEAVFSEEALIQVPSDIPLQ 159 P V G E VV +G+KPGD V+ N +G + + ++ P + Sbjct: 78 PPFVPGIETAG-VVRSAPEGSGIKPGDRVMAFNF-IGGYAERVAVAPSNILPTPPQLDDA 135 Query: 160 SAATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRP 219 A L N T Y QL+ G++V+ + G+G A IQIA +G + I VV Sbjct: 136 EAVALIANYHTMYFAYARRGQLRAGETVLVLGAAGGIGTAAIQIAKGMGAKVIAVV---- 191 Query: 220 DIQKLSDRLKSLGAEHVITEEELRRPEMKNFFKDMPQPRLALNCVGGKSSTELLRQLARG 279 + ++ +KS+GA+ V+ EE + + ++ +GG + + +R LA Sbjct: 192 NRTAATEFVKSVGADIVLPLEEG-WAKAVREATGGAGVDMVVDPIGGPAFDDAVRTLASE 250 Query: 280 GTMVTYGGMAKQPVVASVSLLIFKDLKLRGFWLSQWKKDHSPDQFKELILTLCDLIRRGQ 339 G ++ G A V+ L+ ++ L G ++ + H+ D E L L+ G Sbjct: 251 GRLLVVGFAAGGIPTIKVNRLLLRNASLIGVAWGEFLRTHA-DYLYETQAGLEKLVAEG- 308 Query: 340 LTAPACSQVPLQDYQSALEASMKPFISSKQILT 372 + P +++PL + + AL+ + K +L Sbjct: 309 MRPPVSARIPLSEGRQALQDFADGKVYGKMVLV 341 >1YB5-A nrPDB Length = 351 Score = 241 bits (615), Expect = 3e-64, Method: Composition-based stats. Identities = 71/332 (21%), Positives = 141/332 (42%), Gaps = 11/332 (3%) Query: 43 VRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPELPA 102 +RA+ G P + ++ + + V +K+ A +NP + + G Y P LP Sbjct: 30 MRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPY 89 Query: 103 VGGNEGVAQVVAVGSNVTGLKPGDWVIPANAGLGTWRTEAVFSEEALIQVPSDIPLQSAA 162 G++ + AVG N + K GD V ++ G + A+ ++ + ++P + + A Sbjct: 90 TPGSDVAGVIEAVGDNASAFKKGDRVFTSSTISGGYAEYALAADHTVYKLPEKLDFKQGA 149 Query: 163 TLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQ 222 +G+ TAYR L+ ++ G+SV+ + ++ GVG A QIA A GL+ + + Sbjct: 150 AIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQK 209 Query: 223 KLSDRLKSLGAEHVITEEELRRPEMKNFFKDMPQPRLALNCVGGKSSTELLRQLARGGTM 282 + GA V E+ + + + + + + ++ L L+ GG + Sbjct: 210 IVLQN----GAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGGRV 265 Query: 283 VTYGGMAKQPVVASVSLLIFKDLKLRGFWLSQWKKDHSPDQFKELILTLCDLIRRGQLTA 342 + G ++ + + + K+ + G L + ++F++ L + G L Sbjct: 266 IVVG--SRGTIEINPRDTMAKESSIIGVTLFS----STKEEFQQYAAALQAGMEIGWLKP 319 Query: 343 PACSQVPLQDYQSALEASMKPF-ISSKQILTM 373 SQ PL+ A E + + K IL + Sbjct: 320 VIGSQYPLEKVAEAHENIIHGSGATGKMILLL 351 >3PII-A nrPDB Length = 339 Score = 235 bits (599), Expect = 2e-62, Method: Composition-based stats. Identities = 65/358 (18%), Positives = 132/358 (36%), Gaps = 49/358 (13%) Query: 43 VRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPELPA 102 ++A V +P +++K +E + +V V++ A + +D++ G++ P+LP Sbjct: 1 MKAAVVEQFKEP---LKIKEVEKPTISYGEVLVRIKACGVCHTDLHAAHGDWPVKPKLPL 57 Query: 103 VGGNEGVAQVVAVGSNVTGLKPGDWV---------------------------IPANAGL 135 + G+EGV V VG VT LK GD V + Sbjct: 58 IPGHEGVGIVEEVGPGVTHLKVGDRVGIPWLYSACGHCDYCLSGQETLCEHQKNAGYSVD 117 Query: 136 GTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSG 195 G + + + ++++P ++ + AA + T Y+ L +PG+ V G Sbjct: 118 GGYAEYCRAAADYVVKIPDNLSFEEAAPIFCAGVTTYKAL-KVTGAKPGEWVAIYGI-GG 175 Query: 196 VGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFFKDMP 255 G +Q A A+GL + V + + K LGA+ V+ + + Sbjct: 176 FGHVAVQYAKAMGLNVVAVDIGDEKL----ELAKELGADLVVNPLKEDAAKFMKEKVGGV 231 Query: 256 QPRLALNCVGGKSSTELLRQLARGGTMVTYGGMAKQPVVASVSLLIFKDLKLRGFWLSQW 315 + V + + RGG V G + + + + + +K+ G + Sbjct: 232 HAAVV-TAVSKPAFQSAYNSIRRGGACVLVG-LPPEEMPIPIFDTVLNGIKIIGSIVGT- 288 Query: 316 KKDHSPDQFKELILTLCDLIRRGQLTAPACSQVPLQDYQSALEASMKPFISSKQILTM 373 ++ + G++ PL+ + +K I+ + +LT+ Sbjct: 289 ---------RKDLQEALQFAAEGKVKT-IIEVQPLEKINEVFDRMLKGQINGRVVLTL 336 >3MEQ-A nrPDB Length = 365 Score = 235 bits (599), Expect = 3e-62, Method: Composition-based stats. Identities = 71/371 (19%), Positives = 136/371 (36%), Gaps = 49/371 (13%) Query: 31 ASSYSASAEPARVRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMI 90 A + + ++A V G P + + + + ++V + A+ + +D++ Sbjct: 14 AQTQGPGSMAKTMKAAVVRAFGKP---LTIDEVPIPQPGPGQIQVAIQASGVCHTDLHAA 70 Query: 91 QGNYGFLPELPAVGGNEGVAQVVAVGSNVTGLKPGDWV---------------------- 128 +G++ P P + G+EGV V AVGS V +K GD V Sbjct: 71 EGDWPVKPNPPFIPGHEGVGFVSAVGSGVKHVKEGDRVGIPWLYTACGHCRHCLGGWETL 130 Query: 129 -----IPANAGLGTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQP 183 + G + V + +P +I A + T Y+ L +P Sbjct: 131 CEEQLNTGYSVNGGFAEYVVADPNFVGHLPKNIDFNEIAPVLCAGVTVYKGL-KVTDTKP 189 Query: 184 GDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELR 243 GD V+ + G+G +Q A A+GL V D + D + LGA + + + Sbjct: 190 GDWVVISGI-GGLGHMAVQYARAMGLNVAAVDIDDRKL----DLARRLGATVTVNAKTVA 244 Query: 244 RPEMK-NFFKDMPQPRLALNCVGGKSSTELLRQLARGGTMVTYGGMAKQPVVASVSLLIF 302 P D + + V K+ + L +ARGGT V+ G+ S+ ++ Sbjct: 245 DPAAYIRKETDGGAQGVLVTAVSPKAFEQALGMVARGGT-VSLNGLPPGDFPLSIFNMVL 303 Query: 303 KDLKLRGFWLSQWKKDHSPDQFKELILTLCDLIRRGQLTAPACSQVPLQDYQSALEASMK 362 + +RG + + + D G++ A L+D + + + Sbjct: 304 NGVTVRGSIVGT----------RLDLQESLDFAADGKVKATI-QTGKLEDINAIFDDMRQ 352 Query: 363 PFISSKQILTM 373 I + ++ + Sbjct: 353 GNIEGRIVMDL 363 >4J6F-A nrPDB Length = 382 Score = 232 bits (592), Expect = 2e-61, Method: Composition-based stats. Identities = 77/366 (21%), Positives = 131/366 (35%), Gaps = 49/366 (13%) Query: 40 PARVRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNY----- 94 P + A++ HG K+V +++ + A +V +K+ A +N +D+ + +G Y Sbjct: 31 PKTMTAVLLTGHGGLEKLVYSRDVPVPAPAAGEVLIKVTACGMNNTDVWVREGAYGTEDD 90 Query: 95 ----------GFLPELPAVGGNEGVAQVVAVGSNVTGLKPGDWVIP-------------- 130 G P + G + V +VAVG V + G+ V+ Sbjct: 91 PSAVSTWRRHGNTLTFPRIQGTDTVGHIVAVGEGVDRARIGERVMVDFSIYNRDDDSLAD 150 Query: 131 ----ANAGLGTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDS 186 + G + E V +D+ AT T RML + +L G++ Sbjct: 151 IDYMGHGRDGGYAEYMALPAENAHVVATDLTDIELATFCCAYLTGERML-ERARLAAGET 209 Query: 187 VIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPE 246 V+ ++ GVG A+IQ+A A G I V + L +GA+ V+T + E Sbjct: 210 VLVTGASGGVGSAIIQLARARGAVPIAVAGPGKEAAML-----DIGAQAVVTRGQGDLAE 264 Query: 247 MKNFFKDMPQPRLALNCVGGKSSTELLRQLARGGTMVTYGGMAKQPVVASVSLLIFKDLK 306 + + VGG +LL+ L G T G +A V + + K L+ Sbjct: 265 AVEAASGGRPIDVVADLVGGPLFNDLLKILRPEGRYTTAGAIAGPVVQLDLRTMYLKQLE 324 Query: 307 LRGFWLSQWKKDHSPDQFKELILTLCDLIRRGQLTAPACSQVPLQDYQSALEASMKPFIS 366 L G L I ++ PL ++ A M Sbjct: 325 LHGSSQGSRADFRR----------LVRYIEEKKIRPLVGGVYPLSEFHRAQTDFMAKNFV 374 Query: 367 SKQILT 372 K ++ Sbjct: 375 GKLVVV 380 >5K1S-A nrPDB Length = 362 Score = 231 bits (590), Expect = 3e-61, Method: Composition-based stats. Identities = 73/357 (20%), Positives = 139/357 (38%), Gaps = 43/357 (12%) Query: 43 VRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPELPA 102 ++A+V G+ A ++++ + + +V +++ A + D+ +GN +PA Sbjct: 18 MKAVVLRSFGE-AGNLKMETMPMPRPGRGEVLLRVHACGVCYHDVINRRGNLPRT-SVPA 75 Query: 103 VGGNEGVAQVVAVGSNVTGLKPGDWVI-----------PANAG----------------L 135 + G+E +V+ VG + G K GD +G Sbjct: 76 ILGHEAAGEVIEVGPDTPGWKTGDRAATLQRMSCGDCALCRSGRNSLCKTDNRFFGEELP 135 Query: 136 GTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSG 195 G + V L +VP+ +P AAT+ TA + +++ G++V+ ++ G Sbjct: 136 GGYAQFMVAPVGGLGRVPASLPWNEAATVCCTTGTAVHTVRTRGKVRAGETVLITGASGG 195 Query: 196 VGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFFKDMP 255 VG + +Q+A G R I V +Q LK GA+ VI L Sbjct: 196 VGLSSVQLARLDGARVIAVTSSEAKVQA----LKEAGADEVIVSRGLDFASDVRKRTQGA 251 Query: 256 QPRLALNCVGGKSSTELLRQLARGGTMVTYGGMAKQPVVASVSLLIFKDLKLRGFWLSQW 315 +A+ VG + + L+ +A GG +V G + V + L+I K+L++ G + + Sbjct: 252 GVDVAVEIVGSATFDQTLKSMAPGGRVVVVGNLESGMVQLNPGLVIVKELEILGAYATT- 310 Query: 316 KKDHSPDQFKELILTLCDLIRRGQLTAPACSQVPLQDYQSALEASMKPFISSKQILT 372 + + L G + VPL + A ++ + +L Sbjct: 311 ---------QAELDEALRLTATGGVRQFVTDAVPLAEAAKAHFRLENREVAGRLVLV 358 >4Z6K-A nrPDB Length = 346 Score = 230 bits (585), Expect = 1e-60, Method: Composition-based stats. Identities = 72/356 (20%), Positives = 135/356 (37%), Gaps = 49/356 (13%) Query: 43 VRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPELPA 102 ++A V G ++++ +++ ++ VKM A+ + +D++ ++G++ P P Sbjct: 1 MKAAVLHEFGQS---LQIEEVDIPTPGAGEIVVKMQASGVCHTDLHAVEGDWPVKPSPPF 57 Query: 103 VGGNEGVAQVVAVGSNVTGLKPGDWVIPA---------NAGLGTW--------------- 138 + G+EGV + AVG VT +K GD V A LG W Sbjct: 58 IPGHEGVGLITAVGEGVTHVKEGDRVGVAWLYSACGHCTHCLGGWETLCESQQNSGYSVN 117 Query: 139 ---RTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSG 195 + + + +P + A + T Y+ L +PGD V+ + G Sbjct: 118 GSFAEYVLANANYVGIIPESVDSIEIAPVLCAGVTVYKGL-KMTDTKPGDWVVISGI-GG 175 Query: 196 VGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFFKDMP 255 +G +Q A A+GL V D + K LGA+ + + E Sbjct: 176 LGHMAVQYAIAMGLNVAAVDIDDDKL----AFAKKLGAKVTVNAKNTDPAEYLQKEIGGA 231 Query: 256 QPRLALNCVGGKSSTELLRQLARGGTMVTYGGMAKQPVVASVSLLIFKDLKLRGFWLSQW 315 L V K+ + L L RGGT+V G+ S+ + + +RG + Sbjct: 232 HGALV-TAVSAKAFDQALSMLRRGGTLV-CNGLPPGDFPVSIFDTVLNGITIRGSIVGT- 288 Query: 316 KKDHSPDQFKELILTLCDLIRRGQLTAPACSQVPLQDYQSALEASMKPFISSKQIL 371 + + D+ G++ A ++ PL++ E + I + ++ Sbjct: 289 ---------RLDLQESLDMAAAGKVKATVTAE-PLENINDIFERMRQGKIEGRIVI 334 >1LLU-A nrPDB Length = 342 Score = 226 bits (576), Expect = 1e-59, Method: Composition-based stats. Identities = 72/361 (19%), Positives = 126/361 (34%), Gaps = 49/361 (13%) Query: 40 PARVRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPE 99 P ++A V +G P ++ E+K + V VK+ A+ + +D++ +G++ P Sbjct: 4 PQTMKAAVVHAYGAPLRIEEVK---VPLPGPGQVLVKIEASGVCHTDLHAAEGDWPVKPP 60 Query: 100 LPAVGGNEGVAQVVAVGSNVTGLKPGD-----WVIPANAGL------------------- 135 LP + G+EGV V AVGS VT +K GD W+ A Sbjct: 61 LPFIPGHEGVGYVAAVGSGVTRVKEGDRVGIPWLYTACGCCEHCLTGWETLCESQQNTGY 120 Query: 136 ---GTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNAS 192 G + + + +P ++ A + T Y+ L +PG V + Sbjct: 121 SVNGGYAEYVLADPNYVGILPKNVEFAEIAPILCAGVTVYKGLKQT-NARPGQWVAISGI 179 Query: 193 NSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFFK 252 G+G +Q A A+GL + D + + + LGA + + E Sbjct: 180 -GGLGHVAVQYARAMGLHVAAIDIDDAKL----ELARKLGASLTVNARQEDPVEAIQRDI 234 Query: 253 DMPQPRLALNCVGGKSSTELLRQLARGGTMVTYGGMAKQPVVASVSLLIFKDLKLRGFWL 312 L V + + + RGGT+ G + ++ K L + G + Sbjct: 235 GGAHGVLV-TAVSNSAFGQAIGMARRGGTIALVGLPPG-DFPTPIFDVVLKGLHIAGSIV 292 Query: 313 SQWKKDHSPDQFKELILTLCDLIRRGQLTAPACSQVPLQDYQSALEASMKPFISSKQILT 372 + + D G + A L D L+ I + +L Sbjct: 293 GT----------RADLQEALDFAGEGLVKATIHPG-KLDDINQILDQMRAGQIEGRIVLE 341 Query: 373 M 373 M Sbjct: 342 M 342 >5YAT-A nrPDB Length = 350 Score = 223 bits (567), Expect = 1e-58, Method: Composition-based stats. Identities = 71/361 (19%), Positives = 145/361 (40%), Gaps = 49/361 (13%) Query: 40 PARVRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPE 99 P +A+++ +G P +E K++ + + +++ + + + + +D++ +G++ + Sbjct: 6 PTTQKAVIFETNGGP---LEYKDIPVPKPKSNELLINVKYSGVCHTDLHAWKGDWPLDNK 62 Query: 100 LPAVGGNEGVAQVVAVGSNVTGLKPGDWV---------------------------IPAN 132 LP VGG+EG VVA G NVTG + GD+ + Sbjct: 63 LPLVGGHEGAGVVVAYGENVTGWEIGDYAGIKWLNGSCLNCEYCIQGAESSCAKADLSGF 122 Query: 133 AGLGTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNAS 192 G+++ A ++P + L A + T Y+ L L+ G V + + Sbjct: 123 THDGSFQQYATADATQAARIPKEADLAEVAPILCAGITVYKAL-KTADLRIGQWVAISGA 181 Query: 193 NSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELR--RPEMKNF 250 G+G +Q A ALGLR + + + +KSLGAE + + + E++ Sbjct: 182 GGGLGSLAVQYAKALGLRVLGIDGG----ADKGEFVKSLGAEVFVDFTKTKDVVAEVQKL 237 Query: 251 FKDMPQPRLALNCVGGKSSTELLRQLARGGTMVTYGGMAKQPVVASVSLLIFKDLKLRGF 310 P + + V + + ++ + G +V G + V + V + K ++++G Sbjct: 238 TNGGPHGVINV-SVSPHAINQSVQYVRTLGKVVLVGLPSGAVVNSDVFWHVLKSIEIKGS 296 Query: 311 WLSQWKKDHSPDQFKELILTLCDLIRRGQLTAPACSQVPLQDYQSALEASMKPFISSKQI 370 ++ +E DL RG + AP + L + E I + + Sbjct: 297 YVGN----------REDSAEAIDLFTRGLVKAPI-KIIGLSELAKVYEQMEAGAIIGRYV 345 Query: 371 L 371 + Sbjct: 346 V 346 >2OBY-A nrPDB Length = 338 Score = 222 bits (565), Expect = 2e-58, Method: Composition-based stats. Identities = 79/338 (23%), Positives = 128/338 (37%), Gaps = 11/338 (3%) Query: 41 ARVRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPEL 100 + A+ + G P + +K + + +V +K+ A+ +N +D+ QG Y P Sbjct: 5 IPMLAVHFDKPGGPEN-LYVKEVAKPSPGEGEVLLKVAASALNRADLMQRQGQYDPPPGA 63 Query: 101 PAVGGNEGVAQVVAVGSNVTG-LKPGDWVIPANAGLGTWRTEAVFSEEALIQVPSDIPLQ 159 + G E V +G G K GD + G G E L+ +P + L Sbjct: 64 SNILGLEASGHVAELGPGCQGHWKIGDTAMALLPG-GGQAQYVTVPEGLLMPIPEGLTLT 122 Query: 160 SAATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRP 219 AA + TA+++L +Q GD V+ +A SGVG A IQ+ G + + Sbjct: 123 QAAAIPEAWLTAFQLLHLVGNVQAGDYVLIHAGLSGVGTAAIQLTRMAGAIPLVTAGSQK 182 Query: 220 DIQKLSDRLKSLGAEHVITEEELRRPEMKNFFKDMPQPRLALNCVGGKSSTELLRQLARG 279 +Q + LGA ++ E F L L+C+GG + + LA Sbjct: 183 KLQM----AEKLGAAAGFNYKKEDFSEATLKFTKGAGVNLILDCIGGSYWEKNVNCLALD 238 Query: 280 GTMVTYGGMAKQPVVASV-SLLIFKDLKLRGFWLSQWKKDHSP---DQFKELILTLCDLI 335 G V YG M + + S L+FK L L + + F E IL Sbjct: 239 GRWVLYGLMGGGDINGPLFSKLLFKRGSLITSLLRSRDNKYKQMLVNAFTEQILPHFSTE 298 Query: 336 RRGQLTAPACSQVPLQDYQSALEASMKPFISSKQILTM 373 +L P+ + Q A + K +L + Sbjct: 299 GPQRLLPVLDRIYPVTEIQEAHKYMEANKNIGKIVLEL 336 >4A27-A nrPDB Length = 349 Score = 221 bits (562), Expect = 5e-58, Method: Composition-based stats. Identities = 77/347 (22%), Positives = 142/347 (40%), Gaps = 26/347 (7%) Query: 42 RVRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPELP 101 +RA+V G K + L + + ++++++ A +N D+ + QGN P+ P Sbjct: 3 EMRAVVLAGFGGLNK-LRLFRKAMPEPQDGELKIRVKACGLNFIDLMVRQGNIDNPPKTP 61 Query: 102 AVGGNEGVAQVVAVGSNVTGLKPGDWVIPANAGLGTWRTEAVFSEEALIQVPSDIPLQSA 161 V G E V A+G +V G + GD V+ A W E + ++P D+ A Sbjct: 62 LVPGFECSGIVEALGDSVKGYEIGDRVM-AFVNYNAWAEVVCTPVEFVYKIPDDMSFSEA 120 Query: 162 ATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDI 221 A +N TAY ML + L+ G SV+ +++ GVGQAV Q+ + + T+ Sbjct: 121 AAFPMNFVTAYVMLFEVANLREGMSVLVHSAGGGVGQAVAQLCSTVPNVTVFGTASTFKH 180 Query: 222 QKLSDRLKSLGAEHVITEEELRRPEMKNFFKDMPQPRLALNCVGGKSSTELLRQLARGGT 281 + + D + L + +E++R + + L+C+ G ++ + L L GT Sbjct: 181 EAIKDSVTHLFDRNADYVQEVKRISAE-------GVDIVLDCLCGDNTGKGLSLLKPLGT 233 Query: 282 MVTYG--GMAKQPV--------------VASVSLLIFKDLKLRGF-WLSQWKKDHSPDQF 324 + YG M + L ++ + GF L+ K Sbjct: 234 YILYGSSNMVTGETKSFFSFAKSWWQVEKVNPIKLYEENKVIAGFSLLNLLFKQGRAGLI 293 Query: 325 KELILTLCDLIRRGQLTAPACSQVPLQDYQSALEASMKPFISSKQIL 371 + ++ L L + ++ S L++ + A++ K IL Sbjct: 294 RGVVEKLIGLYNQKKIKPVVDSLWALEEVKEAMQRIHDRGNIGKLIL 340 >3TQH-A nrPDB Length = 321 Score = 220 bits (561), Expect = 6e-58, Method: Composition-based stats. Identities = 73/342 (21%), Positives = 125/342 (36%), Gaps = 31/342 (9%) Query: 37 SAEPARVRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNY-- 94 S ++A+ + G P KV++L + R + + +K+ AA +NP D G+ Sbjct: 1 SNAMKEMKAIQFDQFG-PPKVLKLVDTPTPEYRKNQMLIKVHAASLNPIDYKTRNGSGFV 59 Query: 95 --GFLPELPAVGGNEGVAQVVAVGSNVTGLKPGDWVIP---ANAGLGTWRTEAVFSEEAL 149 LP+ G + +V+ +GS+V + GD V+ + S + + Sbjct: 60 AKKLKNNLPSGLGYDFSGEVIELGSDVNNVNIGDKVMGIAGFPDHPCCYAEYVCASPDTI 119 Query: 150 IQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGL 209 IQ + AA+L TA + L +++ GD V+ +A GVG IQ+A G Sbjct: 120 IQKLEKLSFLQAASLPTAGLTALQALNQ-AEVKQGDVVLIHAGAGGVGHLAIQLAKQKGT 178 Query: 210 RTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFFKDMPQPRLALNCVGGKSS 269 I R LK+LGAE I E ++ VGG Sbjct: 179 TVITTASKRN-----HAFLKALGAEQCINYHEEDF-----LLAISTPVDAVIDLVGGDVG 228 Query: 270 TELLRQLARGGTMVTYGGMAKQPVVASVSLLIFKDLKLRGFWLSQWKKDHSPDQFKELIL 329 + + L G +V+ + A + + K R F K + ++ L Sbjct: 229 IQSIDCLKETGCIVSV-----PTITAGRVIEVAKQKHRRAF---GLLKQFNIEELHYLG- 279 Query: 330 TLCDLIRRGQLTAPACSQVPLQDYQSALEASMKPFISSKQIL 371 L+ +L L + +A E + K + Sbjct: 280 ---KLVSEDKLRIEISRIFQLSEAVTAHELLETGHVRGKLVF 318 >6N7L-A nrPDB Length = 353 Score = 218 bits (554), Expect = 4e-57, Method: Composition-based stats. Identities = 65/359 (18%), Positives = 132/359 (36%), Gaps = 50/359 (13%) Query: 40 PARVRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPE 99 P ++A V +G+P ++++ + + +V VK++A + +D++ + G++ P+ Sbjct: 11 PKTMKAAVVQGYGEP---LKIQEVPVREPGRYEVLVKVMACGVCHTDLHAVDGDWPAKPK 67 Query: 100 LPAVGGNEGVAQVVAVGSNVTGLKPGD-----WVIPANAGL------------------- 135 +P + G+EGV VVA G + +K GD W+ A Sbjct: 68 MPLIPGHEGVGIVVACGPDA-MVKEGDAVGVPWLYSACGCCDYCITGWETLCEAQQNGGY 126 Query: 136 ---GTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNAS 192 G + + + + S++ A + T Y+ L + E +PG+ V + Sbjct: 127 SVDGGFAEYVIADSRYVGHLKSNVNFLEIAPILCAGVTVYKGLKETE-TKPGEWVAISGI 185 Query: 193 NSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFFK 252 G+G +Q A A+G+ + + + K LGA+ + + + Sbjct: 186 -GGLGHVAVQYAKAMGMHVAAIDVADDKL----ELAKKLGADLTVNAKTTDPGTYLHKEV 240 Query: 253 DMPQPRLALNCVGGKSSTELLRQLARGGTMVTYGGMAKQPVVASVSLLIFKDLKLRGFWL 312 L V + + + L R GT+ G + + K + +RG + Sbjct: 241 GGMHGALI-TAVSPIAFKQGIDVLRRKGTIALNGLPPGS-FELPIFETVLKRITVRGSIV 298 Query: 313 SQWKKDHSPDQFKELILTLCDLIRRGQLTAPACSQVPLQDYQSALEASMKPFISSKQIL 371 ++ + D G + A S L+D + K I + +L Sbjct: 299 GT----------RKDLQEALDFANEGLVKATVTSA-KLEDINDVFDKMKKGQIDGRIVL 346 >4RVS-A nrPDB Length = 329 Score = 216 bits (551), Expect = 1e-56, Method: Composition-based stats. Identities = 75/336 (22%), Positives = 121/336 (36%), Gaps = 17/336 (5%) Query: 43 VRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPELPA 102 + A+ G P V+ + ++ +K A +N D G Y ELP Sbjct: 2 MHAIEVTETGGPG-VLRHVDQPQPQPGHGELLIKAEAIGVNFIDTYFRSGQYP--RELPF 58 Query: 103 VGGNEGVAQVVAVGSNVTG----LKPGDWVIPANAGLGTWRTEAVFSEEALIQVPSDIPL 158 V G+E V AVG VT + GD V+ A+A G + +VP D+ Sbjct: 59 VIGSEVCGTVEAVGPGVTAADTAISVGDRVVSASAN-GAYAEFCTAPASLTAKVPDDVTS 117 Query: 159 QSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDR 218 + AA+ + TA+ +L ++ GD+V+ +A GVG + Q A LG+R I V Sbjct: 118 EVAASALLKGLTAHYLLKSVYPVKRGDTVLVHAGAGGVGLILTQWATHLGVRVITTVST- 176 Query: 219 PDIQKLSDRLKSLGAEHVITEEELRR--PEMKNFFKDMPQPRLALNCVGGKSSTELLRQL 276 + + K GA+ V+ E + + VG + L L Sbjct: 177 ---AEKAKLSKDAGADVVLDYPEDAWQFAGRVRELTGGTGVQAVYDGVGATTFDASLASL 233 Query: 277 ARGGTMVTYGGMAKQPVVASVSLL-IFKDLKLRGFWLSQWKKDHSPDQFKELILTLCDLI 335 A GT+ +G + L + L L + + ++ L D I Sbjct: 234 AVRGTLALFGAASGPVPPVDPQRLNAAGSVYLTRPSLFHFTRTGEEFSWR--AAELFDAI 291 Query: 336 RRGQLTAPACSQVPLQDYQSALEASMKPFISSKQIL 371 +T + PL D A + +L Sbjct: 292 GNEAITVAVGGRYPLADALRAHQDLEARKTVGSVVL 327 >3S2F-A nrPDB Length = 340 Score = 215 bits (547), Expect = 3e-56, Method: Composition-based stats. Identities = 69/356 (19%), Positives = 125/356 (35%), Gaps = 49/356 (13%) Query: 43 VRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPELPA 102 ++A V G P + + + + V+VK+ A+ + +D++ G++ P LP Sbjct: 3 MKAAVVRAFGAP---LTIDEVPVPQPGPGQVQVKIEASGVCHTDLHAADGDWPVKPTLPF 59 Query: 103 VGGNEGVAQVVAVGSNVTGLKPGDWV---------------------------IPANAGL 135 + G+EGV V AVGS V+ +K GD V + Sbjct: 60 IPGHEGVGYVSAVGSGVSRVKEGDRVGVPWLYSACGYCEHCLQGWETLCEKQQNTGYSVN 119 Query: 136 GTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSG 195 G + V + +P + A + T Y+ L +PG V+ + G Sbjct: 120 GGYGEYVVADPNYVGLLPDKVGFVEIAPILCAGVTVYKGL-KVTDTRPGQWVVISGI-GG 177 Query: 196 VGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFFKDMP 255 +G +Q A A+GLR V D + + LGAE + + Sbjct: 178 LGHVAVQYARAMGLRVAAVDIDDAKLN----LARRLGAEVAVNARDTDPAAWLQKEIGGA 233 Query: 256 QPRLALNCVGGKSSTELLRQLARGGTMVTYGGMAKQPVVASVSLLIFKDLKLRGFWLSQW 315 L V K+ ++ + + RGGT + G+ + ++ K + +RG + Sbjct: 234 HGVLV-TAVSPKAFSQAIGMVRRGGT-IALNGLPPGDFGTPIFDVVLKGITIRGSIVGT- 290 Query: 316 KKDHSPDQFKELILTLCDLIRRGQLTAPACSQVPLQDYQSALEASMKPFISSKQIL 371 + + D G + A S L D + + + +L Sbjct: 291 ---------RSDLQESLDFAAHGDVKATV-STAKLDDVNDVFGRLREGKVEGRVVL 336 >3COS-A nrPDB Length = 381 Score = 215 bits (547), Expect = 3e-56, Method: Composition-based stats. Identities = 70/360 (19%), Positives = 127/360 (35%), Gaps = 69/360 (19%) Query: 33 SYSASAEPARVRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQG 92 S + + +A + G P + + +E+A + +VR++++A + +D +I Sbjct: 1 SMGTKGKVIKCKAAIAWEAGKPLCI---EEVEVAPPKAHEVRIQIIATSLCHTDATVIDS 57 Query: 93 NYGFLPELPAVGGNEGVAQVVAVGSNVTGLKPGDWVIPANA------------------- 133 + L P + G+E V ++G VT +KPGD VIP A Sbjct: 58 KFEGLA-FPVIVGHEAAGIVESIGPGVTNVKPGDKVIPLYAPLCRKCKFCLSPLTNLCGK 116 Query: 134 --------------------------------GLGTWRTEAVFSEEALIQVPSDIPLQSA 161 G T+ V S+ L ++ D L+ Sbjct: 117 ISNLKSPASDQQLMEDKTSRFTCKGKPVYHFFGTSTFSQYTVVSDINLAKIDDDANLERV 176 Query: 162 ATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDI 221 LG T Y ++ ++ PG S GVG + + A G I + Sbjct: 177 CLLGCGFSTGYGAAINNAKVTPG-STCAVFGLGGVGLSAVMGCKAAGASRIIGIDIN--- 232 Query: 222 QKLSDRLKSLGAEHVITEEELRRPEMKNFFKDMPQP--RLALNCVGGKSSTELLRQLARG 279 + + K+LGA + +L +P ++ ++ + AL+C GG + + Sbjct: 233 SEKFVKAKALGATDCLNPRDLHKP-IQEVIIELTKGGVDFALDCAGGSETMKAALDCTTA 291 Query: 280 G----TMVTYGGMAKQPVVASVSLLIFKDLKLRGFWLSQWKK-DHSPDQFKELILTLCDL 334 G T + +K V L+I + + G + WK D P + +L Sbjct: 292 GWGSCTFIGVAAGSKGLTVFPEELIIGR--TINGTFFGGWKSVDSIPKLVTDYKNKKFNL 349 >3UOG-A nrPDB Length = 363 Score = 208 bits (528), Expect = 4e-54, Method: Composition-based stats. Identities = 75/337 (22%), Positives = 117/337 (34%), Gaps = 39/337 (11%) Query: 58 VELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPELPAVGGNEGVAQVVAVGS 117 ++L + D+ V+ LA +N D +++ G P V ++ V AVG Sbjct: 41 LKLAERPVPEAGEHDIIVRTLAVSLNYRDKLVLETGMGLDLAFPFVPASDMSGVVEAVGK 100 Query: 118 NVTGLKPGDWVI------------------PANAGLGT-----WRTEAVFSEEALIQVPS 154 +VT +PGD VI PA LG V E + P Sbjct: 101 SVTRFRPGDRVISTFAPGWLDGLRPGTGRTPAYETLGGAHPGVLSEYVVLPEGWFVAAPK 160 Query: 155 DIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINV 214 + A+TL TA+ L++ L+ GD V+ GV +QIA A G I Sbjct: 161 SLDAAEASTLPCAGLTAWFALVEKGHLRAGDRVVVQG-TGGVALFGLQIAKATGAEVIVT 219 Query: 215 VRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFFKDMPQPRLALNCVGGKSSTELLR 274 R + DR +LGA+H I E E L GG + L+ Sbjct: 220 SSSREKL----DRAFALGADHGINRLEEDWVERVYALTGDRGADHILEIAGGAGLGQSLK 275 Query: 275 QLARGGTMVTYGGMAKQPVVASVSLLIFKDLKLRGFWLSQWKKDHSPDQFKELILTLCDL 334 +A G + G + V V L+ K ++G + + + L Sbjct: 276 AVAPDGRISVIGVLEGFEVSGPVGPLLLKSPVVQGISVGH----------RRALEDLVGA 325 Query: 335 IRRGQLTAPACSQVPLQDYQSALEASMKPFISSKQIL 371 + R L + + AL A + K ++ Sbjct: 326 VDRLGLKPVIDMRYKFTEVPEAL-AHLDRGPFGKVVI 361 >5ENV-A nrPDB Length = 347 Score = 208 bits (528), Expect = 4e-54, Method: Composition-based stats. Identities = 66/361 (18%), Positives = 124/361 (34%), Gaps = 49/361 (13%) Query: 40 PARVRALV-YGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLP 98 P + ++ Y HG +E K++ + + +++ + + + + +D++ G++ Sbjct: 3 PETQKGVIFYESHGK----LEYKDIPVPKPKANELLINVKYSGVCHTDLHAWHGDWPLPV 58 Query: 99 ELPAVGGNEGVAQVVAVGSNVTGLKPGDWV---------------------------IPA 131 +LP VGG+EG VV +G NV G K GD+ + Sbjct: 59 KLPLVGGHEGAGVVVGMGENVKGWKIGDYAGIKWLNGSCMACEYCELGNESNCPHADLSG 118 Query: 132 NAGLGTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNA 191 G+++ A +P L A + T Y+ L L G V + Sbjct: 119 YTHDGSFQQYATADAVQAAHIPQGTDLAQVAPILCAGITVYKAL-KSANLMAGHWVAISG 177 Query: 192 SNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFF 251 + G+G +Q A A+G R + + + +S+G E I + + Sbjct: 178 AAGGLGSLAVQYAKAMGYRVLGIDGGEGK----EELFRSIGGEVFIDFTKEKDIVGAVLK 233 Query: 252 KDMPQPRLALN-CVGGKSSTELLRQLARGGTMVTYGGMAKQPVVASVSLLIFKDLKLRGF 310 +N V + R + GT V G A + V + K + + G Sbjct: 234 ATDGGAHGVINVSVSEAAIEASTRYVRANGTTVLVGMPAGAKCCSDVFNQVVKSISIVGS 293 Query: 311 WLSQWKKDHSPDQFKELILTLCDLIRRGQLTAPACSQVPLQDYQSALEASMKPFISSKQI 370 ++ + D RG + +P V L E K I + + Sbjct: 294 YVGN----------RADTREALDFFARGLVKSPI-KVVGLSTLPEIYEKMEKGQIVGRYV 342 Query: 371 L 371 + Sbjct: 343 V 343 >1U3W-A nrPDB Length = 374 Score = 198 bits (504), Expect = 2e-51, Method: Composition-based stats. Identities = 79/376 (21%), Positives = 133/376 (35%), Gaps = 81/376 (21%) Query: 35 SASAEPARVRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNY 94 S + + + +A V + K ++ +E+A + +VR+KM+AA I SD +++ GN Sbjct: 1 STAGKVIKCKAAVLW---ELKKPFSIEEVEVAPPKAHEVRIKMVAAGICRSDEHVVSGN- 56 Query: 95 GFLPELPAVGGNEGVAQVVAVGSNVTGLKPGDWVIPANA--------------------- 133 + LP + G+E V +VG VT +KPGD VIP Sbjct: 57 -LVTPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRICKNPESNYCLKND 115 Query: 134 --------------------------GLGTWRTEAVFSEEALIQVPSDIPLQSAATLGVN 167 G+ T+ V E A+ ++ + PL+ +G Sbjct: 116 LGNPRGTLQDGTRRFTCSGKPIHHFVGVSTFSQYTVVDENAVAKIDAASPLEKVCLIGCG 175 Query: 168 PCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDR 227 T Y + ++ PG S GVG +V+ A G I V D + Sbjct: 176 FSTGYGSAVKVAKVTPG-STCAVFGLGGVGLSVVMGCKAAGAARIIAVDINKD---KFAK 231 Query: 228 LKSLGAEHVITEEELRRPEMKNFFKDMP--QPRLALNCVGG-KSSTELLRQLAR-GGTMV 283 K LGA I ++ ++P ++ K+M + +G + L GT V Sbjct: 232 AKELGATECINPQDYKKP-IQEVLKEMTDGGVDFSFEVIGQLDTMMASLLCCHEACGTSV 290 Query: 284 TYGGMAKQPVVASVSLLIFKDLKLRGFWLSQWKKDHSPDQF------------------- 324 G ++ +L+ +G +K S + Sbjct: 291 IVGVPPDSQNLSINPMLLLTGRTWKGAIFGGFKSKESVPKLVADFMAKKFSLDALITNVL 350 Query: 325 -KELILTLCDLIRRGQ 339 E I DL+R G+ Sbjct: 351 PFEKINEGFDLLRSGK 366 >1HSO-A nrPDB Length = 374 Score = 197 bits (501), Expect = 6e-51, Method: Composition-based stats. Identities = 73/352 (20%), Positives = 128/352 (36%), Gaps = 62/352 (17%) Query: 35 SASAEPARVRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNY 94 S + + + +A V + K ++ +E+A + +VR+KM+A I +D +++ G Sbjct: 1 STAGKVIKCKAAVLW---ELKKPFSIEEVEVAPPKAHEVRIKMVAVGICGTDDHVVSGTM 57 Query: 95 GFLPELPAVGGNEGVAQVVAVGSNVTGLKPGDWVIPA----------------------- 131 + LP + G+E V +VG VT +KPGD VIP Sbjct: 58 --VTPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLAIPQCGKCRICKNPESNYCLKND 115 Query: 132 ------------------------NAGLGTWRTEAVFSEEALIQVPSDIPLQSAATLGVN 167 G+ T+ V E A+ ++ + PL+ +G Sbjct: 116 VSNPQGTLQDGTSRFTCRRKPIHHFLGISTFSQYTVVDENAVAKIDAASPLEKVCLIGCG 175 Query: 168 PCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDR 227 T Y ++ ++ PG S GVG + I A G I V D + Sbjct: 176 FSTGYGSAVNVAKVTPG-STCAVFGLGGVGLSAIMGCKAAGAARIIAVDINKD---KFAK 231 Query: 228 LKSLGAEHVITEEELRRPEMKNFFKDMP--QPRLALNCVGG-KSSTELLRQLAR-GGTMV 283 K LGA I ++ ++P ++ K+M + +G + L GT V Sbjct: 232 AKELGATECINPQDYKKP-IQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSV 290 Query: 284 TYGGMAKQPVVASVSLLIFKDLKLRGFWLSQWK-KDHSPDQFKELILTLCDL 334 G ++ +L+ +G L +K K+ P + + L Sbjct: 291 IVGVPPDSQNLSMNPMLLLTGRTWKGAILGGFKSKECVPKLVADFMAKKFSL 342 >2EER-A nrPDB Length = 347 Score = 195 bits (496), Expect = 2e-50, Method: Composition-based stats. Identities = 70/367 (19%), Positives = 128/367 (34%), Gaps = 58/367 (15%) Query: 43 VRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLP---- 98 +RA+ G P ++L+++ + +GS V +K+ AA + SD++M QG +G L Sbjct: 1 MRAMRLVEIGKP---LKLEDIPIPKPKGSQVLIKIEAAGVCHSDVHMRQGRFGNLRIVED 57 Query: 99 ---ELPAVGGNEGVAQVVAVGSNVTGLKPGDWVIPANAGL-------------------- 135 +LP G+E ++ VG V G GD V Sbjct: 58 LGVKLPVTLGHEIAGRIEEVGDEVVGYSKGDLVAVNPWEGEGNCYYCRIGEEHLCDSPRW 117 Query: 136 ------GTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQ 189 G + + + + AA L + T YR + L P +++ Sbjct: 118 LGINYDGAYAEYVLVPHYKYLYKLRRLSAVEAAPLTCSGVTTYRAVRK-ASLDPSKTLVV 176 Query: 190 NASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKN 249 + G+G IQIA A+ TI V R ++ + K GA++VI Sbjct: 177 IGAGGGLGTMAIQIAKAVSGATIIGVDVR---EEALEAAKRAGADYVINASSQDPVSEIR 233 Query: 250 FFKDMPQPRLALNCVGGKSSTELLRQ----LARGGTMVTYGGMAKQPVVASVSLLIFKDL 305 ++ +S + L LA+ G V G + L+ ++ Sbjct: 234 RITQGKGADAVIDL---NNSEKTLSIYPYVLAKQGKYVMVGLF-GADLKYHAPLITLNEV 289 Query: 306 KLRGFWLSQWKKDHSPDQFKELILTLCDLIRRGQLTAPACSQVPLQDYQSALEASMKPFI 365 + G + + L + L G++ + L++ A++ Sbjct: 290 QFIGSLVGN----------QSDFLGIMSLAEAGKVKPMVTKTMKLEEANEAIDNLENFKA 339 Query: 366 SSKQILT 372 +Q+L Sbjct: 340 VGRQVLV 346 >2WEK-A nrPDB Length = 341 Score = 194 bits (493), Expect = 5e-50, Method: Composition-based stats. Identities = 63/277 (22%), Positives = 104/277 (37%), Gaps = 19/277 (6%) Query: 55 AKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPELPAVGGNEGVAQVVA 114 V ++ + D+ V+ +N SDIN G Y + P G EG+ +VVA Sbjct: 17 EAVTLSRDCPVPLPGDGDLLVRNRFVGVNASDINYSAGRYDPSVKPPFDIGFEGIGEVVA 76 Query: 115 VGSNVTGLKPGDWVIPANAGLGTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYRM 174 +G + + + A G++ V VPS P TL V+ TAY Sbjct: 77 LGLSASARYTVGQAV-AYMAPGSFAEYTVVPASIATPVPSVKP--EYLTLLVSGTTAYIS 133 Query: 175 LMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAE 234 L + L G V+ A+ G GQ +Q++ I S LKSLG + Sbjct: 134 LKELGGLSEGKKVLVTAAAGGTGQFAMQLSKKAKCHVIGTCSSDEK----SAFLKSLGCD 189 Query: 235 HVITEEELRRPEMKNFFKDMPQP-RLALNCVGGKSSTELLRQLARGGTMVTYGGMAKQPV 293 I + P ++ P+ + VGG + LA G ++ G ++ Sbjct: 190 RPINYK--TEPVGTVLKQEYPEGVDVVYESVGGAMFDLAVDALATKGRLIVIGFISGYQT 247 Query: 294 VASVSL---------LIFKDLKLRGFWLSQWKKDHSP 321 +S L+ K ++GF+L+ + + Sbjct: 248 PTGLSPVKAGTLPAKLLKKSASVQGFFLNHYLSKYQA 284 >1HSZ-A nrPDB Length = 374 Score = 194 bits (493), Expect = 5e-50, Method: Composition-based stats. Identities = 69/352 (19%), Positives = 125/352 (35%), Gaps = 62/352 (17%) Query: 35 SASAEPARVRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNY 94 S + + + +A V P ++++E+A + +VR+KM+A I +D +++ GN Sbjct: 1 STAGKVIKCKAAVLWEVKKP---FSIEDVEVAPPKAYEVRIKMVAVGICRTDDHVVSGN- 56 Query: 95 GFLPELPAVGGNEGVAQVVAVGSNVTGLKPGDWVIPANA--------------------- 133 + LP + G+E V +VG VT +KPGD VIP Sbjct: 57 -LVTPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRVCKNPESNYCLKND 115 Query: 134 --------------------------GLGTWRTEAVFSEEALIQVPSDIPLQSAATLGVN 167 G T+ V E A+ ++ + PL+ +G Sbjct: 116 LGNPRGTLQDGTRRFTCRGKPIHHFLGTSTFSQYTVVDENAVAKIDAASPLEKVCLIGCG 175 Query: 168 PCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDR 227 T Y ++ ++ PG S GVG + + A G I V D + Sbjct: 176 FSTGYGSAVNVAKVTPG-STCAVFGLGGVGLSAVMGCKAAGAARIIAVDINKD---KFAK 231 Query: 228 LKSLGAEHVITEEELRRPEMKNFFKDMP--QPRLALNCVGG-KSSTELLRQLARGGTMVT 284 K LGA I ++ ++P ++ K+M + +G + L Sbjct: 232 AKELGATECINPQDYKKP-IQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSV 290 Query: 285 YGGMAKQPVVASVSLL-IFKDLKLRGFWLSQWK-KDHSPDQFKELILTLCDL 334 G+ S++ + + +G +K K+ P + + L Sbjct: 291 IVGVPPASQNLSINPMLLLTGRTWKGAVYGGFKSKEGIPKLVADFMAKKFSL 342 >1V3V-A nrPDB Length = 333 Score = 192 bits (487), Expect = 3e-49, Method: Composition-based stats. Identities = 73/345 (21%), Positives = 139/345 (40%), Gaps = 33/345 (9%) Query: 42 RVRALVYGHH--GDPAKV-VELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLP 98 + ++ H G P + ELK +EL ++ +V ++ L ++P M + Sbjct: 7 KAKSWTLKKHFQGKPTQSDFELKTVELPPLKNGEVLLEALFLSVDP---YMRIASKRLKE 63 Query: 99 ELPAVGGNEGVAQVVAVGSNVTGLKPGDWVIPANAGLGTWRTEAVFS----EEALIQVPS 154 AV + VA+VV ++ P ++ A +G W T + E+ L + P Sbjct: 64 G--AVMMGQQVARVVESKNSAF---PAGSIVLAQSG---WTTHFISDGKGLEKLLTEWPD 115 Query: 155 DIPLQSA-ATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTIN 213 +PL A T+G+ TAY L++ ++ G++V+ +A+ VG V QIA G + + Sbjct: 116 KLPLSLALGTIGMPGLTAYFGLLEVCGVKGGETVLVSAAAGAVGSVVGQIAKLKGCKVVG 175 Query: 214 VVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFFKDMPQPRLALNCVGGKSSTELL 273 I LK +G + + + E + VGG+ +L Sbjct: 176 AAGSDEKI----AYLKQIGFDAAFNYKTVNSLEEALKKASPDGYDCYFDNVGGEFLNTVL 231 Query: 274 RQL------ARGGTMVTYGGMAKQPVVASVSLLIFKDLKLRGFWLSQWKKDHSPDQFKEL 327 Q+ A G + Y M + P S +I+K L++ GF + +W+ D ++L Sbjct: 232 SQMKDFGKIAICGAISVYNRMDQLPPGPSPESIIYKQLRIEGFIVYRWQGDVREKALRDL 291 Query: 328 ILTLCDLIRRGQLTAPACSQVPLQDYQSALEASMKPFISSKQILT 372 + + G++ ++ +A + K ++T Sbjct: 292 M----KWVLEGKIQYHEHVTKGFENMPAAFIEMLNGANLGKAVVT 332 >1H2B-A nrPDB Length = 359 Score = 191 bits (484), Expect = 6e-49, Method: Composition-based stats. Identities = 75/373 (20%), Positives = 143/373 (38%), Gaps = 55/373 (14%) Query: 34 YSASAEPARVRALVYGHHGDPAKVVELKNLELAAVRGS-DVRVKMLAAPINPSDINMIQG 92 +S S R++A + P + +++++ + G DV V++ A + +D++++QG Sbjct: 7 FSQSLGVERLKAARLHEYNKP---LRIEDVDYPRLEGRFDVIVRIAGAGVCHTDLHLVQG 63 Query: 93 NYG--FLPELPAVGGNEGVAQVVAVGSNVTGLKPGDWVI--------------------- 129 + P+LP G+E V + V V GL+ GD VI Sbjct: 64 MWHELLQPKLPYTLGHENVGYIEEVAEGVEGLEKGDPVILHPAVTDGTCLACRAGEDMHC 123 Query: 130 -----PANAGLGTWRTEAVFSEEALIQVPSDIP---LQSAATLGVNPCTAYRMLMDFEQ- 180 P G + S ++I++P DI L A L TAYR + + Sbjct: 124 ENLEFPGLNIDGGFAEFMRTSHRSVIKLPKDISREKLVEMAPLADAGITAYRAVKKAART 183 Query: 181 LQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEE 240 L PG V G+G +Q+ + T+ + + + KL++R LGA+HV+ Sbjct: 184 LYPGAYVAIVG-VGGLGHIAVQLLKVMTPATVIALDVKEEKLKLAER---LGADHVVDAR 239 Query: 241 ELRRPEMKNFFKDMPQPRLALNCVGGKSSTELLR-QLARGGTMVTYGGMAKQPVVASVSL 299 ++ +A++ VG +++ + L R G ++ G + Sbjct: 240 RDPVKQVME-LTRGRGVNVAMDFVGSQATVDYTPYLLGRMGRLIIVGY--GGELRFPTIR 296 Query: 300 LIFKDLKLRGFWLSQWKKDHSPDQFKELILTLCDLIRRGQLTAPACSQVPLQDYQSALEA 359 +I ++ G + + + H L L +G++ L + LE Sbjct: 297 VISSEVSFEGSLVGNYVELH----------ELVTLALQGKVRVEV-DIHKLDEINDVLER 345 Query: 360 SMKPFISSKQILT 372 K + + +L Sbjct: 346 LEKGEVLGRAVLI 358 >2VN8-A nrPDB Length = 375 Score = 189 bits (481), Expect = 1e-48, Method: Composition-based stats. Identities = 76/357 (21%), Positives = 123/357 (34%), Gaps = 38/357 (10%) Query: 45 ALVYGHHGDPAKVVELKNLELAAVR-GSDVRVKMLAAPINPSDINMIQGNYGFLP----- 98 A V +G + +N+ + + ++V VK+ AA +NP D+NM G Sbjct: 24 AWVIDKYGKNEVLRFTQNMMMPIIHYPNEVIVKVHAASVNPIDVNMRSGYGATALNMKRD 83 Query: 99 ---------ELPAVGGNEGVAQVVAVGSNVTGLKPGDWVIPA--NAGLGTWRTEAVFSEE 147 E P G + V+ G +V KPGD V A GT V S Sbjct: 84 PLHVKIKGEEFPLTLGRDVSGVVMECGLDVKYFKPGDEVWAAVPPWKQGTLSEFVVVSGN 143 Query: 148 ALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQP----GDSVIQNASNSGVGQAVIQI 203 + P + AA+L TA+ + L G V+ ++ GVG IQ+ Sbjct: 144 EVSHKPKSLTHTQAASLPYVALTAWSAINKVGGLNDKNCTGKRVLILGASGGVGTFAIQV 203 Query: 204 AAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFFKDMPQPRLALNC 263 A V Q S+ ++ LGA+ VI + + ++ K + L+ Sbjct: 204 MKAWDAHVTAVCS-----QDASELVRKLGADDVI---DYKSGSVEEQLKSLKPFDFILDN 255 Query: 264 VGGKSSTELLRQLAR--GGTMVTYG--GMAKQPVVASVSLLIFKDLKLRGFWLSQ-WKKD 318 VGG + T L + G T VT + + ++ + + L WK Sbjct: 256 VGGSTETWAPDFLKKWSGATYVTLVTPFLLNMDRLGIADGMLQTGVTVGSKALKHFWKGV 315 Query: 319 HSPDQFKELILTLCD----LIRRGQLTAPACSQVPLQDYQSALEASMKPFISSKQIL 371 H F D L+ G++ P A + K ++ Sbjct: 316 HYRWAFFMASGPCLDDIAELVDAGKIRPVIEQTFPFSKVPEAFLKVERGHARGKTVI 372 >1E3E-A nrPDB Length = 376 Score = 189 bits (480), Expect = 2e-48, Method: Composition-based stats. Identities = 66/352 (18%), Positives = 125/352 (35%), Gaps = 68/352 (19%) Query: 39 EPARVRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLP 98 + + +A + G P + + +E++ + +VR++++A + P+DIN L Sbjct: 5 KVIKCKAAIAWKTGSPLCI---EEIEVSPPKACEVRIQVIATCVCPTDINATDPKKKAL- 60 Query: 99 ELPAVGGNEGVAQVVAVGSNVTGLKPGDWVIPANA------------------------- 133 P V G+E V +VG VT KPGD VIP A Sbjct: 61 -FPVVLGHECAGIVESVGPGVTNFKPGDKVIPFFAPQCKRCKLCLSPLTNLCGKLRNFKY 119 Query: 134 --------------------------GLGTWRTEAVFSEEALIQVPSDIPLQSAATLGVN 167 G+ ++ V SE L +V + L+ +G Sbjct: 120 PTIDQELMEDRTSRFTCKGRSIYHFMGVSSFSQYTVVSEANLARVDDEANLERVCLIGCG 179 Query: 168 PCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDR 227 + Y ++ ++ PG S VG + I G I + + + Sbjct: 180 FSSGYGAAINTAKVTPG-STCAVFGLGCVGLSAIIGCKIAGASRIIAIDING---EKFPK 235 Query: 228 LKSLGAEHVITEEELRRPEMKNFFKDMP--QPRLALNCVGGKSSTELLRQLA--RGGTMV 283 K+LGA + EL +P +++ ++ +L+C G + + G+ Sbjct: 236 AKALGATDCLNPRELDKP-VQDVITELTAGGVDYSLDCAGTAQTLKAAVDCTVLGWGSCT 294 Query: 284 TYGGMAKQPVVASVSLLIFKDLKLRGFWLSQWKK-DHSPDQFKELILTLCDL 334 G + + +V +++ + + G + WK D P+ + DL Sbjct: 295 VVGAKVDEMTIPTVDVILGR--SINGTFFGGWKSVDSVPNLVSDYKNKKFDL 344 >1MC5-A nrPDB Length = 374 Score = 189 bits (479), Expect = 2e-48, Method: Composition-based stats. Identities = 62/278 (22%), Positives = 100/278 (35%), Gaps = 58/278 (20%) Query: 37 SAEPARVRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGF 96 + E + +A V G P + ++ +E+A + +VR+K++A + +D + G Sbjct: 2 ANEVIKCKAAVAWEAGKP---LSIEEIEVAPPKAHEVRIKIIATAVCHTDAYTLSGADPE 58 Query: 97 LPELPAVGGNEGVAQVVAVGSNVTGLKPGDWVIPA------------------------- 131 P + G+EG V +VG VT LK GD VIP Sbjct: 59 G-CFPVILGHEGAGIVESVGEGVTKLKAGDTVIPLYIPQCGECKFCLNPKTNLCQKIRVT 117 Query: 132 ----------------------NAGLGTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPC 169 G T+ V ++ ++ ++ PL LG Sbjct: 118 QGKGLMPDGTSRFTCKGKTILHYMGTSTFSEYTVVADISVAKIDPLAPLDKVCLLGCGIS 177 Query: 170 TAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLK 229 T Y ++ +L+PG SV GVG AVI G I V D R K Sbjct: 178 TGYGAAVNTAKLEPG-SVCAVFGLGGVGLAVIMGCKVAGASRIIGVDINKD---KFARAK 233 Query: 230 SLGAEHVITEEELRRPEMKNFFKDMP--QPRLALNCVG 265 GA I ++ +P ++ +M + C+G Sbjct: 234 EFGATECINPQDFSKP-IQEVLIEMTDGGVDYSFECIG 270 >5A3V-A nrPDB Length = 329 Score = 186 bits (473), Expect = 1e-47, Method: Composition-based stats. Identities = 69/338 (20%), Positives = 137/338 (40%), Gaps = 25/338 (7%) Query: 43 VRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGF--LPEL 100 + AL Y +G A +E + + + ++V +K+ A +NP D + +G + Sbjct: 6 MHALQYNSYGGGAAGLEHVQVPVPTPKSNEVCLKLEATSLNPVDWKIQKGMIRPFLPRKF 65 Query: 101 PAVGGNEGVAQVVAVGSNVTGLKPGDWV--IPANAGLGTWRTEAVFSEEALIQVPSDIPL 158 P + + +VV VGS V K GD V + ++ G G AV +E+ ++ P ++ Sbjct: 66 PCIPATDVAGEVVEVGSGVKNFKAGDKVVAVLSHLGGGGLAEFAVATEKLTVKRPQEVGA 125 Query: 159 QSAATLGVNPCTAYRMLMDFEQLQ---PGD--SVIQNASNSGVGQAVIQIAAALGLRTIN 213 AA L V TA + L + L+ G +++ A++ GVG +Q+A Sbjct: 126 AEAAALPVAGLTALQALTNPAGLKLDGTGKKANILVTAASGGVGHYAVQLAKLANAHVTA 185 Query: 214 VVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFFKDMPQPRLALNCVGGKSSTELL 273 R + +KSLGA+ V+ + +K+ + ++C G + Sbjct: 186 TCGARN-----IEFVKSLGADEVLDYKTPEGAALKS--PSGKKYDAVVHCANGIPFSVFE 238 Query: 274 RQLARGGTMVTYGGMAKQPVVASVSLLIFKDLKLRGFWLSQWKKDHSPDQFKELILTLCD 333 L+ G ++ P ++ K + + L + + ++ + Sbjct: 239 PNLSENGKVIDI-----TPGPNAMWTYAVKKITMSKKQLVPLLLIPKAENLEFMV----N 289 Query: 334 LIRRGQLTAPACSQVPLQDYQSALEASMKPFISSKQIL 371 L++ G++ S+ PL + A S+ + K I+ Sbjct: 290 LVKEGKVKTVIDSKHPLSKAEDAWAKSIDGHATGKIIV 327 >1EE2-A nrPDB Length = 373 Score = 185 bits (470), Expect = 2e-47, Method: Composition-based stats. Identities = 66/351 (18%), Positives = 123/351 (35%), Gaps = 61/351 (17%) Query: 35 SASAEPARVRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNY 94 S + + + +A V P ++ +E+A + +VR+KM+AA I SD +++ G Sbjct: 1 STAGKVIKCKAAVLWEQKKP---FSIEEVEVAPPKAHEVRIKMVAAGICRSDDHVVSGT- 56 Query: 95 GFLPELPAVGGNEGVAQVVAVGSNVTGLKPGDWVIPAN---------------------- 132 + LP + G+E V ++G VT ++PGD VIP Sbjct: 57 -LVAPLPVIAGHEAAGIVESIGEGVTTVRPGDKVIPLFIPQCGKCSVCKHPEGNLCLKNL 115 Query: 133 ------------------------AGLGTWRTEAVFSEEALIQVPSDIPLQSAATLGVNP 168 G T+ V E ++ ++ + PL+ +G Sbjct: 116 SMPRGTMQDGTSRFTCRGKPIHHFLGTSTFSQYTVVDEISVAKIDAASPLEKVCLVGCGF 175 Query: 169 CTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRL 228 T Y + ++ G S GVG +VI A G I V D + Sbjct: 176 STGYGSAVKVAKVTQG-STCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKD---KFAKA 231 Query: 229 KSLGAEHVITEEELRRPEMKNFFKDM--PQPRLALNCVGG-KSSTELLRQLARGGTMVTY 285 K +GA + ++ ++P ++ +M + +G + L + Sbjct: 232 KEVGATECVNPQDYKKP-IQEVLTEMSNGGVDFSFEVIGRLDTMVAALSCCQEAYGVSVI 290 Query: 286 GGMAKQPVVASVSLL-IFKDLKLRGFWLSQWK-KDHSPDQFKELILTLCDL 334 G+ S++ + + +G +K KD P + + L Sbjct: 291 VGVPPDSQNLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFAL 341 >1O89-A nrPDB Length = 345 Score = 184 bits (468), Expect = 4e-47, Method: Composition-based stats. Identities = 66/339 (19%), Positives = 133/339 (39%), Gaps = 28/339 (8%) Query: 43 VRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPELPA 102 ++AL+ D + ++ L+ + + DV V + + +N D I G + P Sbjct: 22 LQALLLEQQ-DGKTLASVQTLDESRLPEGDVTVDVHWSSLNYKDALAITGKGKIIRNFPM 80 Query: 103 VGGNEGVAQVVAVGSNVTGLKPGDWVIPANAGL-----GTWRTEAVFSEEALIQVPSDIP 157 + G + V S G V+ G+ G +A + L+ +P + Sbjct: 81 IPGIDFAGTVRT--SEDPRFHAGQEVLLTGWGVGENHWGGLAEQARVKGDWLVAMPQGLD 138 Query: 158 LQSAATLGVNPCTAYRMLM--DFEQLQPGD-SVIQNASNSGVGQAVIQIAAALGLRTINV 214 + A +G TA +M + ++P D ++ ++ GVG + + LG + + V Sbjct: 139 ARKAMIIGTAGFTAMLCVMALEDAGVRPQDGEIVVTGASGGVGSTAVALLHKLGYQVVAV 198 Query: 215 VRDRPDIQKLSDRLKSLGAEHVITEEEL--RRPEMKNFFKDMPQPRLALNCVGGKSSTEL 272 + + LKSLGA V+ +E RP K + A++ VG K ++ Sbjct: 199 SG----RESTHEYLKSLGASRVLPRDEFAESRPLEKQVWAG------AIDTVGDKVLAKV 248 Query: 273 LRQLARGGTMVTYGGMAKQPVVASVSLLIFKDLKLRGFWLSQWKKDHSPDQFKELILTLC 332 L Q+ GG + G + +V I ++++L+G + ++ L+ L Sbjct: 249 LAQMNYGGCVAACGLAGGFTLPTTVMPFILRNVRLQGVDSVMTPPERRAQAWQRLVADLP 308 Query: 333 DLIRRGQLTAPACSQVPLQDYQSALEASMKPFISSKQIL 371 + A ++ L + + EA + I + ++ Sbjct: 309 ESF-----YTQAAKEISLSEAPNFAEAIINNQIQGRTLV 342 >1D1T-A nrPDB Length = 373 Score = 184 bits (467), Expect = 5e-47, Method: Composition-based stats. Identities = 66/349 (18%), Positives = 123/349 (35%), Gaps = 61/349 (17%) Query: 37 SAEPARVRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGF 96 + + + +A V P ++ +E+A + +VR+K+LA I +D ++I+G Sbjct: 3 AGKVIKCKAAVLWEQKQP---FSIEEIEVAPPKTKEVRIKILATGICRTDDHVIKGTM-- 57 Query: 97 LPELPAVGGNEGVAQVVAVGSNVTGLKPGDWVIPA------------------------- 131 + + P + G+E V ++G VT +KPGD VIP Sbjct: 58 VSKFPVIVGHEATGIVESIGEGVTTVKPGDKVIPLFLPQCRECNACRNPDGNLCIRSDIT 117 Query: 132 ---------------------NAGLGTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCT 170 T+ V E ++ ++ P + +G T Sbjct: 118 GRGVLADGTTRFTCKGKPVHHFLNTSTFTEYTVVDESSVAKIDDAAPPEKVCLIGCGFST 177 Query: 171 AYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKS 230 Y + +++PG S GVG +VI + G I + D ++ + Sbjct: 178 GYGAAVKTGKVKPG-STCVVFGLGGVGLSVIMGCKSAGASRIIGIDLNKD---KFEKAMA 233 Query: 231 LGAEHVITEEELRRPEMKNFFKDMPQPRL--ALNCVGGKSS--TELLRQLARGGTMVTYG 286 +GA I+ ++ +P + +M + +G + L GT V G Sbjct: 234 VGATECISPKDSTKP-ISEVLSEMTGNNVGYTFEVIGHLETMIDALASCHMNYGTSVVVG 292 Query: 287 GMAKQPVVASVSLLIFKDLKLRGFWLSQWK-KDHSPDQFKELILTLCDL 334 ++ +L+F +G K +D P E + DL Sbjct: 293 VPPSAKMLTYDPMLLFTGRTWKGCVFGGLKSRDDVPKLVTEFLAKKFDL 341 >2J3K-A nrPDB Length = 345 Score = 183 bits (464), Expect = 1e-46, Method: Composition-based stats. Identities = 72/330 (21%), Positives = 132/330 (40%), Gaps = 32/330 (9%) Query: 53 DPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPELPAVGGNEGVAQV 112 + V +KNL L+ D +++ +PS + Q + P P G GV+++ Sbjct: 36 EGTNSVLVKNLYLSC----DPYMRIRMGKPDPSTAALAQA---YTPGQPIQG--YGVSRI 86 Query: 113 VAVGSNVTGLKPGDWVIPANAGLGTWRTEAVFSEEALIQV---PSDIPLQSA-ATLGVNP 168 + G K GD + G+ W +V + +D+PL LG+ Sbjct: 87 IESGH--PDYKKGDLL----WGIVAWEEYSVITPMTHAHFKIQHTDVPLSYYTGLLGMPG 140 Query: 169 CTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRL 228 TAY + + G++V +A++ VGQ V Q+A +G + + + L + Sbjct: 141 MTAYAGFYEVCSPKEGETVYVSAASGAVGQLVGQLAKMMGCYVVGSAGSKEKVDLLKTKF 200 Query: 229 KSLGAEHVITEEELRRPEMKNFFKDMPQPRLALNCVGGKSSTELLRQLARGGTMVTYG-- 286 A + E +L + F + + VGGK +L + G + G Sbjct: 201 GFDDAFNYKEESDLTAALKRCFPNGI---DIYFENVGGKMLDAVLVNMNMHGRIAVCGMI 257 Query: 287 ---GMAKQPVVASVSLLIFKDLKLRGFWLSQWKKDHSPDQFKELILTLCDLIRRGQLTAP 343 + Q V ++S +I+K +++GF +S + +S +F E +L IR G++T Sbjct: 258 SQYNLENQEGVHNLSNIIYKRNRIQGFVVSDFYDKYS--KFLEFVLP---HIREGKITYV 312 Query: 344 ACSQVPLQDYQSALEASMKPFISSKQILTM 373 L+ AL KQ++ + Sbjct: 313 EDVADGLEKAPEALVGLFHGKNVGKQVVVV 342 >4RQU-A nrPDB Length = 375 Score = 183 bits (463), Expect = 2e-46, Method: Composition-based stats. Identities = 70/388 (18%), Positives = 130/388 (33%), Gaps = 67/388 (17%) Query: 38 AEPARVRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFL 97 ++ R +A V G P + ++ +E+A + +VR+K+L + +D+ + G Sbjct: 1 SQIIRCKAAVAWEAGKP---LVIEEVEVAPPQKHEVRIKILFTSLCHTDVYFWEAK-GQT 56 Query: 98 PELPAVGGNEGVAQVVAVGSNVTGLKPGDWVIPANA------------------------ 133 P P + G+E V +VG VT L+PGD V+P Sbjct: 57 PLFPRIFGHEAGGIVESVGEGVTDLQPGDHVLPIFTGECGECRHCHSEESNMCDLLRINT 116 Query: 134 ------------------------GLGTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPC 169 G T+ V + ++ D PL + Sbjct: 117 ERGGMIHDGESRFSINGKPIYHFLGTSTFSEYTVVHSGQVAKINPDAPLDKVCIVSCGLS 176 Query: 170 TAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLK 229 T ++ + + G SV VG + A G I V K D+ K Sbjct: 177 TGLGATLNVAKPKKGQSVAI-FGLGAVGLGAAEGARIAGASRIIGVDFN---SKRFDQAK 232 Query: 230 SLGAEHVITEEELRRPEMKNFFKDMP--QPRLALNCVGG-KSSTELLRQLARG-GTMVTY 285 G + ++ +P ++ +M ++ C G ++ + + G G V Sbjct: 233 EFGVTECVNPKDHDKP-IQQVIAEMTDGGVDRSVECTGSVQAMIQAFECVHDGWGVAVLV 291 Query: 286 GGMAKQPVVASVSLLIFKDLKLRGFWLSQWKKDHSPDQFKELILTLCDLIRRGQLTAPAC 345 G +K + + + L+G + +K E + + +L Sbjct: 292 GVPSKDDAFKTHPMNFLNERTLKGTFFGNYKPKTDIPGVVEKYMN-----KELELEKFIT 346 Query: 346 SQVPLQDYQSALEASMKPFISSKQILTM 373 VP + A + +K S + I+TM Sbjct: 347 HTVPFSEINKAFDYMLKGE-SIRCIITM 373 >4DLA-A nrPDB Length = 396 Score = 182 bits (461), Expect = 3e-46, Method: Composition-based stats. Identities = 67/347 (19%), Positives = 119/347 (34%), Gaps = 61/347 (17%) Query: 32 SSYSASAEPARVRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQ 91 SS + + +A V +P K + ++++++A + +VRVK+L + +D Sbjct: 16 SSSATQGQVITCKAAVAW---EPNKPLVIEDVQVAPPQAGEVRVKVLYTALCHTDAYTWS 72 Query: 92 GNYGFLPELPAVGGNEGVAQVVAVGSNVTGLKPGDWVIPAN------------------- 132 G P V G+E V +VG VT ++PGD VIP Sbjct: 73 GKDPEG-LFPCVLGHEAAGIVESVGEGVTEVQPGDHVIPCYQAECRECKFCKSGKTNLCG 131 Query: 133 -----------------------------AGLGTWRTEAVFSEEALIQVPSDIPLQSAAT 163 G T+ V + ++ ++ PL+ Sbjct: 132 KVRAATGVGVMMNDRKSRFSINGKPIYHFMGTSTFSQYTVVHDVSVAKIDPVAPLEKVCL 191 Query: 164 LGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQK 223 LG T + + +++PG S++ VG AV + A A G I + K Sbjct: 192 LGCGVPTGLGAVWNTAKVEPG-SIVAVFGLGTVGLAVAEGAKAAGASRIIGIDID---SK 247 Query: 224 LSDRLKSLGAEHVITEEELRRPEMKNFFKDMP--QPRLALNCVGGKSSTELLRQL--ARG 279 DR K+ G I +E +P ++ D+ + C+G S + Sbjct: 248 KFDRAKNFGVTEFINPKEHEQP-IQQVIVDLTDGGVDYSFECIGNVSVMRSALECCHKGW 306 Query: 280 GTMVTYGGMAKQPVVASVSLLIFKDLKLRGFWLSQWKKDHSPDQFKE 326 GT V G A +++ + +G +K + Sbjct: 307 GTSVIVGVAASGQEISTRPFQLVTGRVWKGTAFGGFKSRSQVPSLVD 353 >1CDO-A nrPDB Length = 374 Score = 181 bits (459), Expect = 4e-46, Method: Composition-based stats. Identities = 66/380 (17%), Positives = 128/380 (33%), Gaps = 72/380 (18%) Query: 39 EPARVRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDI-NMIQGNYGFL 97 + + +A V P + ++ +E+ +++R+K++A + +D+ ++ +G + Sbjct: 5 KVIKCKAAVAWEANKP---LVIEEIEVDVPHANEIRIKIIATGVCHTDLYHLFEGKHK-- 59 Query: 98 PELPAVGGNEGVAQVVAVGSNVTGLKPGDWVIPA-------------------------- 131 P V G+EG V +VG VT +PG+ VIP Sbjct: 60 DGFPVVLGHEGAGIVESVGPGVTEFQPGEKVIPLFISQCGECRFCQSPKTNQCVKGWANE 119 Query: 132 ---------------------NAGLGTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCT 170 G T+ V ++ A+ ++ PL + LG T Sbjct: 120 SPDVMSPKETRFTCKGRKVLQFLGTSTFSQYTVVNQIAVAKIDPSAPLDTVCLLGCGVST 179 Query: 171 AYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKS 230 + ++ +++PG S VG A + + G + I V PD ++ K Sbjct: 180 GFGAAVNTAKVEPG-STCAVFGLGAVGLAAVMGCHSAGAKRIIAVDLNPD---KFEKAKV 235 Query: 231 LGAEHVITEEELRRPEMKNFFK-DMPQPRLALNCVG--GKSSTELLRQLARGGTMVTYGG 287 GA + + P + K +L CVG G L L G V G Sbjct: 236 FGATDFVNPNDHSEPISQVLSKMTNGGVDFSLECVGNVGVMRNALESCLKGWGVSVLVGW 295 Query: 288 MA-KQPVVASVSLLIFKDLKLRGFWLSQWKKDHSPDQFKELILTLCDLIRRGQLTAP--A 344 + L+ + +G +K K+ + + ++ Sbjct: 296 TDLHDVATRPIQLIAGR--TWKGSMFGGFKG-------KDGVPKMVKAYLDKKVKLDEFI 346 Query: 345 CSQVPLQDYQSALEASMKPF 364 ++PL+ A++ Sbjct: 347 THRMPLESVNDAIDLMKHGK 366 >3FBG-A nrPDB Length = 346 Score = 177 bits (449), Expect = 6e-45, Method: Composition-based stats. Identities = 60/347 (17%), Positives = 130/347 (37%), Gaps = 28/347 (8%) Query: 43 VRALVYGHHGDPAK--VVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPEL 100 ++A+ + + + + NL++ + ++ VK+ + +NP D + + + Sbjct: 3 LKAIGFEQPFKLSDGNLFKTFNLDIPEPKVHEILVKIQSISVNPVDTKQRLMD---VSKA 59 Query: 101 PAVGGNEGVAQVVAVGSNVTGLKPGDWVIPANAG--LGTWRTEAVFSEEALIQVPSDIPL 158 P V G + + V +VG+ VT GD V + + G+ + +E + + P +I Sbjct: 60 PRVLGFDAIGVVESVGNEVTMFNQGDIVYYSGSPDQNGSNAEYQLINERLVAKAPKNISA 119 Query: 159 QSAATLGVNPCTAYRMLMDFEQL------QPGDSVIQNASNSGVGQAVIQIAAALGLRTI 212 + A +L + TAY L D + G +++ GVG QIA A GLR I Sbjct: 120 EQAVSLPLTGITAYETLFDVFGISRNRNENEGKTLLIINGAGGVGSIATQIAKAYGLRVI 179 Query: 213 NVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFFKDMPQPRLALNCVGGKS-STE 271 I + K +GA+ V+ +E + K ++ + Sbjct: 180 TTASRNETI----EWTKKMGADIVLNHKESLLNQFKTQGIEL--VDYVFCTFNTDMYYDD 233 Query: 272 LLRQLARGGTMVTYGGMAKQPVVASVSLLIFKDLKLRGFWLSQWKKDHSPDQFK--ELIL 329 +++ + G + T ++ L K L ++ + + D K E + Sbjct: 234 MIQLVKPRGHIATIVAFEN---DQDLNALKPKSLSFSHEFMFARPLNQTDDMIKHHEYLE 290 Query: 330 TLCDLIRRGQ---LTAPACSQVPLQDYQSALEASMKPFISSKQILTM 373 + + + + T + ++ A + + K ++ + Sbjct: 291 DITNKVEQNIYQPTTTKVIEGLTTENIYQAHQILESNTMIGKLVINL 337 >5FI5-A nrPDB Length = 357 Score = 176 bits (446), Expect = 2e-44, Method: Composition-based stats. Identities = 67/301 (22%), Positives = 107/301 (35%), Gaps = 38/301 (12%) Query: 28 GPAASSYSASAEPARVRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDI 87 GPA +S S S E V+A D + + N A DV++K+L D Sbjct: 1 GPAMASKSPSEEVYPVKAFGLAAK-DSSGLFSPFNFSRRATGEHDVQLKVLYCGTCQYDR 59 Query: 88 NMIQGNYGFLPELPAVGGNEGVAQVVAVGSNVTGLKPGDWVIPAN--------------- 132 M + +GF P V G+E V +V VGS V K GD V A+ Sbjct: 60 EMSKNKFGFT-SYPYVLGHEIVGEVTEVGSKVQKFKVGDKVGVASIIETCGKCEMCTNEV 118 Query: 133 -----------AGLGTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQL 181 + G AV +E +I+ P ++PL S L TAY + + Sbjct: 119 ENYCPEAGSIDSNYGACSNIAVINENFVIRWPENLPLDSGVPLLCAGITAYSPMKRYGLD 178 Query: 182 QPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEE 241 +PG + ++ A A G + + ++K + + GA+ + Sbjct: 179 KPGKRIGIAGLGGLG-HVALRFAKAFGAKVTVISSS---LKKKREAFEKFGADSFLVSSN 234 Query: 242 LRRPEMKNFFKDMPQPRLALNCV-GGKSSTELLRQLARGGTMVTYGGMAKQPVVASVSLL 300 + ++ + G S LL L G ++ G V + SLL Sbjct: 235 -----PEEMQGAAGTLDGIIDTIPGNHSLEPLLALLKPLGKLIILGAPEMPFEVPAPSLL 289 Query: 301 I 301 + Sbjct: 290 M 290 >4EEZ-A nrPDB Length = 348 Score = 175 bits (443), Expect = 3e-44, Method: Composition-based stats. Identities = 62/358 (17%), Positives = 135/358 (37%), Gaps = 51/358 (14%) Query: 43 VRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPELPA 102 ++A V H+ P +L EL A++ ++ + M + +D+++ G++G Sbjct: 1 MKAAVVRHN--PDGYADLVEKELRAIKPNEALLDMEYCGVCHTDLHVAAGDFGNKAGT-- 56 Query: 103 VGGNEGVAQVVAVGSNVTGLKPGDWVIPA---------------------------NAGL 135 V G+EG+ V +G++V+ L+ GD V A + Sbjct: 57 VLGHEGIGIVKEIGADVSSLQVGDRVSVAWFFEGCGHCEYCVSGNETFCREVKNAGYSVD 116 Query: 136 GTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSG 195 G EA+ + ++VP + A+++ T Y+ + ++PGD + + G Sbjct: 117 GGMAEEAIVVADYAVKVPDGLDPIEASSITCAGVTTYKAI-KVSGVKPGDWQVIFGA-GG 174 Query: 196 VGQAVIQIAA-ALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFFKDM 254 +G IQ A G + I V ++ + K +GA+ I ++ + Sbjct: 175 LGNLAIQYAKNVFGAKVIAVDINQDKLN----LAKKIGADVTINSGDVNPVDEIKKITGG 230 Query: 255 PQPRLALNC-VGGKSSTELLRQLARGGTMVTYGGMAKQPVVASVSLLIFKDLKLRGFWLS 313 + A+ C V + + + L G MV + + SV ++F +++ G + Sbjct: 231 LGVQSAIVCAVARIAFEQAVASLKPMGKMVAV-AVPNTEMTLSVPTVVFDGVEVAGSLVG 289 Query: 314 QWKKDHSPDQFKELILTLCDLIRRGQLTAPACSQVPLQDYQSALEASMKPFISSKQIL 371 + + G++ P + L++ ++ I + ++ Sbjct: 290 T----------RLDLAEAFQFGAEGKVK-PIVATRKLEEINDIIDEMKAGKIEGRMVI 336 >1P0F-A nrPDB Length = 373 Score = 174 bits (441), Expect = 5e-44, Method: Composition-based stats. Identities = 67/343 (19%), Positives = 119/343 (34%), Gaps = 60/343 (17%) Query: 41 ARVRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPEL 100 +A V +P K + L+ + +A + +VR+K+LA+ I SD ++++ + Sbjct: 8 ITCKAAVAW---EPHKPLSLETITVAPPKAHEVRIKILASGICGSDSSVLKEIIP--SKF 62 Query: 101 PAVGGNEGVAQVVAVGSNVTGLKPGDWVIPAN---------------------------- 132 P + G+E V V ++G+ VT +KPGD VIP Sbjct: 63 PVILGHEAVGVVESIGAGVTCVKPGDKVIPLFVPQCGSCRACKSSNSNFCEKNDMGAKTG 122 Query: 133 -------------------AGLGTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYR 173 G T+ V ++ A+ ++ PL + +G T Y Sbjct: 123 LMADMTSRFTCRGKPIYNLMGTSTFTEYTVVADIAVAKIDPKAPL-ESCLIGCGFATGYG 181 Query: 174 MLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGA 233 ++ ++ PG S GVG + I A G I V D + LGA Sbjct: 182 AAVNTAKVTPG-STCAVFGLGGVGFSAIVGCKAAGASRIIGVGTHKD---KFPKAIELGA 237 Query: 234 EHVITEEELRRPEMKNF-FKDMPQPRLALNCVGGKSSTELLRQLARG--GTMVTYGGMAK 290 + ++ +P + K A+ C G + Q G V G + Sbjct: 238 TECLNPKDYDKPIYEVICEKTNGGVDYAVECAGRIETMMNALQSTYCGSGVTVVLGLASP 297 Query: 291 QPVVASVSLLIFKDLKLRGFWLSQWKKDHSPDQFKELILTLCD 333 + LL+ L+G +K + + + + Sbjct: 298 NERLPLDPLLLLTGRSLKGSVFGGFKGEEVSRLVDDYMKKKIN 340 >3SLK-A nrPDB Length = 795 Score = 174 bits (440), Expect = 7e-44, Method: Composition-based stats. Identities = 73/308 (23%), Positives = 121/308 (39%), Gaps = 18/308 (5%) Query: 66 AAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPELPAVGGNEGVAQVVAVGSNVTGLKPG 125 A + +VR+ M AA +N D + G Y + G+EG VV G VTGL PG Sbjct: 234 APLGDGEVRIAMRAAGVNFRDALIALGMYPGVAS----LGSEGAGVVVETGPGVTGLAPG 289 Query: 126 DWVIPANAGLGTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGD 185 D V+ + AV + ++P+ AA++ + TAY L+D L+PG+ Sbjct: 290 DRVMG--MIPKAFGPLAVADHRMVTRIPAGWSFARAASVPIVFLTAYYALVDLAGLRPGE 347 Query: 186 SVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRP 245 S++ +++ GVG A IQ+A LG + + L EH+ + Sbjct: 348 SLLVHSAAGGVGMAAIQLARHLGAEVYATASED------KWQAVELSREHLASSRTCDFE 401 Query: 246 EMKNFFKDMPQPRLALNCVGGKSSTELLRQLARGGTMVTYGGMAKQPVVASVSLLIFKDL 305 + + LN + G+ + LR L RGG + G + V + Sbjct: 402 QQFLGATGGRGVDVVLNSLAGEFADASLRMLPRGGRFLELGKTDVRDPVEVADAH--PGV 459 Query: 306 KLRGFWLSQWKKDHSPDQFKELILTLCDLIRRGQLTAPACSQVPLQDYQSALEASMKPFI 365 + F + P + E++ L +L L + ++ AL + Sbjct: 460 SYQAFDTVE----AGPQRIGEMLHELVELFEGRVLEPLPVTAWDVRQAPEALRHLSQARH 515 Query: 366 SSKQILTM 373 K +LTM Sbjct: 516 VGKLVLTM 523 >4UEJ-A nrPDB Length = 346 Score = 173 bits (438), Expect = 1e-43, Method: Composition-based stats. Identities = 69/360 (19%), Positives = 136/360 (37%), Gaps = 45/360 (12%) Query: 43 VRALVYGHHGDPAKVVELKNLELAAVR-GSDVRVKMLAAPINPSDINMIQGNYGFLPELP 101 ++++V D +V + + ++ +VRVK+ ++ + SD+ I N P Sbjct: 1 MKSVV----NDTDGIVRVAESVIPEIKHQDEVRVKIASSGLCGSDLPRIFKNGAHY--YP 54 Query: 102 AVGGNEGVAQVVAVGSNVTGLKPGDWV--IPANAGL------------------------ 135 G+E + AVGS V L PGD V +P Sbjct: 55 ITLGHEFSGYIDAVGSGVDDLHPGDAVACVPLLPCFTCPECLKGFYSQCAKYDFIGSRRD 114 Query: 136 GTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSG 195 G + V + + +P+D+P++ A + P T Q +VI + Sbjct: 115 GGFAEYIVVKRKNVFALPTDMPIEDGAFI--EPITVGLHAFHLAQGCENKNVIIIGA-GT 171 Query: 196 VGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFFKDMP 255 +G IQ A ALG +++ + + KS GA E+ P+M++ +++ Sbjct: 172 IGLLAIQCAVALGAKSVTAIDIS---SEKLALAKSFGAMQTFNSSEMSAPQMQSVLRELR 228 Query: 256 QPRLALNCVGGKSSTELLRQLARGGTMVTYGGMAKQP---VVASVSLLIFKDLKLRGFWL 312 +L L G + EL ++A + G Q A+ ++ K+L + G W+ Sbjct: 229 FNQLILETAGVPQTVELAVEIAGPHAQLALVGTLHQDLHLTSATFGKILRKELTVIGSWM 288 Query: 313 SQWKKDHSPDQFKELILTLCDLIRRGQLTAPACSQVPLQDYQSALEASMKPFISSKQILT 372 + + +++ L + R+ L + + + A+ + + K +L Sbjct: 289 N-YSSPWPGQEWETASRLLTE--RKLSLEPLIAHRGSFESFAQAVRDIARNAMPGKVLLI 345 >4JJI-A nrPDB Length = 378 Score = 173 bits (438), Expect = 1e-43, Method: Composition-based stats. Identities = 58/340 (17%), Positives = 110/340 (32%), Gaps = 61/340 (17%) Query: 39 EPARVRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLP 98 + +A V +P K + ++++++A + +VR+K+L + +D G Sbjct: 5 QVITCKAAVAY---EPNKPLVIEDVQVAPPQAGEVRIKILYTALCHTDAYTWSGKDPEG- 60 Query: 99 ELPAVGGNEGVAQVVAVGSNVTGLKPGDWVIPAN-------------------------- 132 P + G+E V +VG VT ++ GD VIP Sbjct: 61 LFPCILGHEAAGIVESVGEGVTEVQAGDHVIPCYQAECRECKFCKSGKTNLCGKVRSATG 120 Query: 133 ----------------------AGLGTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCT 170 G T+ V + ++ ++ PL LG T Sbjct: 121 VGIMMNDRKSRFSVNGKPIYHFMGTSTFSQYTVVHDVSVAKIDPTAPLDKVCLLGCGVPT 180 Query: 171 AYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKS 230 + + +++PG +V VG AV + A G I + K + K Sbjct: 181 GLGAVWNTAKVEPGSNVAI-FGLGTVGLAVAEGAKTAGASRIIGIDID---SKKYETAKK 236 Query: 231 LGAEHVITEEELRRPEMKNFFKDMP--QPRLALNCVGGKSSTELLRQL--ARGGTMVTYG 286 G + ++ +P ++ D+ + C+G S + GT V G Sbjct: 237 FGVNEFVNPKDHDKP-IQEVIVDLTDGGVDYSFECIGNVSVMRAALECCHKGWGTSVIVG 295 Query: 287 GMAKQPVVASVSLLIFKDLKLRGFWLSQWKKDHSPDQFKE 326 A +++ + +G +K E Sbjct: 296 VAASGQEISTRPFQLVTGRVWKGTAFGGFKSRTQVPWLVE 335 >3HZZ-A nrPDB Length = 467 Score = 170 bits (431), Expect = 8e-43, Method: Composition-based stats. Identities = 62/390 (15%), Positives = 125/390 (32%), Gaps = 76/390 (19%) Query: 41 ARVRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINM----------- 89 + A + DP K + L + + + + V ++A+ +N + + Sbjct: 59 TEMFAGLETRDKDPRKSIHLDEVPVPELGPGEALVAVMASSVNYNSVWTSIFEPVSTFAF 118 Query: 90 --IQGNYGFLPE---LPA-VGGNEGVAQVVAVGSNVTGLKPGD----------------- 126 G L + LP + G++ V+ G V +PGD Sbjct: 119 LERYGKLSPLTKRHDLPYHIIGSDLAGVVLRTGPGVNAWQPGDEVVAHCLSVELESPDGH 178 Query: 127 ---------WVIPANAGLGTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYRML-- 175 + G A+ L+ P + + AA G+ TAYR L Sbjct: 179 DDTMLDPEQRIWGFETNFGGLAEIALVKTNQLMPKPKHLTWEEAAAPGLVNSTAYRQLVS 238 Query: 176 MDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEH 235 + ++ GD+V+ ++ G+G Q A A G I VV + ++ +S+GAE Sbjct: 239 RNGAAMKQGDNVLIWGASGGLGSYATQFALAGGANPICVVSS----PQKAEICRSMGAEA 294 Query: 236 VITE--------EELRRPEMKNF---------FKDMPQPRLALNCVGGKSSTELLRQLAR 278 +I ++ + K + + G ++ + + Sbjct: 295 IIDRNAEGYKFWKDEHTQDPKEWKRFGKRIRELTGGEDIDIVFEHPGRETFGASVYVTRK 354 Query: 279 GGTMVTYGGMAKQPVVASVSLLIFKDLKLRGFWLSQWKKDHSPDQFKELILTLCDLIRRG 338 GGT+ T + L ++ G + +++ + LI +G Sbjct: 355 GGTITTCASTSGYMHEYDNRYLWMSLKRIIGSHFANYREAY----------EANRLIAKG 404 Query: 339 QLTAPACSQVPLQDYQSALEASMKPFISSK 368 ++ L++ A + K Sbjct: 405 KIHPTLSKTYSLEETGQAAYDVHRNLHQGK 434 >1R37-A nrPDB Length = 347 Score = 167 bits (423), Expect = 7e-42, Method: Composition-based stats. Identities = 67/364 (18%), Positives = 126/364 (34%), Gaps = 52/364 (14%) Query: 43 VRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLP---- 98 +RA+ G P + L+ + + +G V +K+ AA + SD++M QG +G L Sbjct: 1 MRAVRLVEIGKP---LSLQEIGVPKPKGPQVLIKVEAAGVCHSDVHMRQGRFGNLRIVED 57 Query: 99 ---ELPAVGGNEGVAQVVAVGSNVTGLKPGDWVIPANAGL-------------------- 135 +LP G+E ++ VG V G GD V Sbjct: 58 LGVKLPVTLGHEIAGKIEEVGDEVVGYSKGDLVAVNPWQGEGNCYYCRIGEEHLCDSPRW 117 Query: 136 ------GTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQ 189 G + + + + AA L + T YR + L P +++ Sbjct: 118 LGINFDGAYAEYVIVPHYKYMYKLRRLNAVEAAPLTCSGITTYRAVRK-ASLDPTKTLLV 176 Query: 190 NASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKN 249 + G+G +QIA A+ TI V R ++ + K GA++VI Sbjct: 177 VGAGGGLGTMAVQIAKAVSGATIIGVDVR---EEAVEAAKRAGADYVINASMQDPLAEIR 233 Query: 250 FFKDMPQPRLALN-CVGGKSSTELLRQLARGGTMVTYGGMAKQPVVASVSLLIFKDLKLR 308 + ++ K+ + + LA+ G V G + L+ +++ Sbjct: 234 RITESKGVDAVIDLNNSEKTLSVYPKALAKQGKYVMVGLF-GADLHYHAPLITLSEIQFV 292 Query: 309 GFWLSQWKKDHSPDQFKELILTLCDLIRRGQLTAPACSQVPLQDYQSALEASMKPFISSK 368 G + + L + L G++ + L++ A++ + Sbjct: 293 GSLVGN----------QSDFLGIMRLAEAGKVKPMITKTMKLEEANEAIDNLENFKAIGR 342 Query: 369 QILT 372 Q+L Sbjct: 343 QVLI 346 >2Y05-A nrPDB Length = 328 Score = 167 bits (422), Expect = 8e-42, Method: Composition-based stats. Identities = 68/329 (20%), Positives = 134/329 (40%), Gaps = 38/329 (11%) Query: 58 VELKNLELAAVRGSDVRVKMLAAPINP----SDINMIQGNYGFLPELPAVGGNEGVAQVV 113 ELK EL ++ +V ++ L ++P + + +G+ + VA+VV Sbjct: 21 FELKTSELPPLKNGEVLLEALFLTVDPYMRVAAKRLKEGD---------TMMGQQVAKVV 71 Query: 114 AVGSNVTGLKPGDWVIPANAGLGTWRTEAVFS----EEALIQVPSDIPLQSA-ATLGVNP 168 + P ++ A+ G W T ++ E+ L + P IPL A T+G+ Sbjct: 72 ESKNVAL---PKGTIVLASPG---WTTHSISDGKDLEKLLTEWPDTIPLSLALGTVGMPG 125 Query: 169 CTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRL 228 TAY L++ ++ G++V+ NA+ VG V QIA G + + V + L Sbjct: 126 LTAYFGLLEICGVKGGETVMVNAAAGAVGSVVGQIAKLKGCKVVGAVGSDEKV----AYL 181 Query: 229 KSLGAEHVITEEELRRPEMKNFFKDMPQPRLALNCVGGKSSTELLRQLARGGTMVTYGGM 288 + LG + V + + E + VGG+ S ++ Q+ + G + G + Sbjct: 182 QKLGFDVVFNYKTVESLEETLKKASPDGYDCYFDNVGGEFSNTVIGQMKKFGRIAICGAI 241 Query: 289 AK------QPVVASVSLLIFKDLKLRGFWLSQWKKDHSPDQFKELILTLCDLIRRGQLTA 342 + P ++I+++L++ F + +W+ D K+ L + G++ Sbjct: 242 STYNRTGPLPPGPPPEIVIYQELRMEAFVVYRWQGDARQKALKD----LLKWVLEGKIQY 297 Query: 343 PACSQVPLQDYQSALEASMKPFISSKQIL 371 ++ +A +K K I+ Sbjct: 298 KEYIIEGFENMPAAFMGMLKGDNLGKTIV 326 >4IDE-A nrPDB Length = 332 Score = 166 bits (420), Expect = 1e-41, Method: Composition-based stats. Identities = 73/280 (26%), Positives = 118/280 (42%), Gaps = 29/280 (10%) Query: 28 GPAASSYSASAEPARVRALVYGHHGDPAKVVELK-NLELAAVRGSDVRVKMLAAPINPSD 86 G AA S S P+ +A VY +G + V++ ++ + ++ V +K++AA +NP D Sbjct: 12 GAAAPSESI---PSVNKAWVYSEYGKTSDVLKFDPSVAVPEIKEDQVLIKVVAASLNPVD 68 Query: 87 INMIQGNYGFLPEL-PAVGGNEGVAQVVAVGSNVTGLKPGDWVIP--------ANAGLGT 137 G + P + G + VV VGS VT K GD V G+ Sbjct: 69 FKRALGYFKDTDSPLPTIPGYDVAGVVVKVGSQVTKFKVGDEVYGDLNETALVNPTRFGS 128 Query: 138 WRTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVG 197 E L P ++ AA+L + TA+ L + +L G SV+ GVG Sbjct: 129 LAEYTAADERVLAHKPKNLSFIEAASLPLAIETAHEGL-ERAELSAGKSVLVLGGAGGVG 187 Query: 198 QAVIQIAAA-LGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFFKDMP- 255 +IQ+A G + K D L++LGA+ I K F+D+P Sbjct: 188 THIIQLAKHVFGASKVAATAST----KKLDLLRTLGADLAIDY-------TKENFEDLPE 236 Query: 256 QPRLALNCVGGKSSTELLRQLARGGTMVTYGGMAKQPVVA 295 + + + VG + + ++ + GG +VT G A P + Sbjct: 237 KFDVVYDAVG--ETDKAVKAVKEGGKVVTIVGPATPPAIL 274 >4CPD-A nrPDB Length = 347 Score = 165 bits (418), Expect = 3e-41, Method: Composition-based stats. Identities = 86/355 (24%), Positives = 138/355 (38%), Gaps = 59/355 (16%) Query: 43 VRALVYGHHGDPAKVVELKNLELAAVR-GSDVRVKMLAAPINPSDINMIQGNYGFLPELP 101 +RA+V+ + + V +K + ++ D V++ A I SD+++ G LP Sbjct: 1 MRAVVFEN----KERVAVKEVNAPRLQHPLDALVRVHLAGICGSDLHLYHGKIPVLPG-- 54 Query: 102 AVGGNEGVAQVVAVGSNVTGLKPGDWVI-PANAGLGTW-----RTEAV------------ 143 +V G+E V QV AVG + L+PGDWV+ P + GT + Sbjct: 55 SVLGHEFVGQVEAVGEGIQDLQPGDWVVGPFHIACGTCPYCRRHQYNLCERGGVYGYGPM 114 Query: 144 ---------------FSEEALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVI 188 FS L ++P ++ + A G TAY L+ QL+PGDSV Sbjct: 115 FGNLQGAQAEILRVPFSNVNLRKLPPNLSPERAIFAGDILSTAYGGLIQ-GQLRPGDSVA 173 Query: 189 QNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMK 248 + VG I++A LG I + I + +R SLGA + E+E ++ Sbjct: 174 VIGAGP-VGLMAIEVAQVLGASKILAID---RIPERLERAASLGAIPINAEQENPVRRVR 229 Query: 249 NFFKDMPQPRLALNCVGGKSSTE-LLRQLARGGTMVTYGGMAKQPVVASVSLLIFKDLKL 307 + D P L L VGG ++ L + GG + G ++ + KDL Sbjct: 230 SETND-EGPDLVLEAVGGAATLSLALEMVRPGGRVSAVGVDNAPSFPFPLASGLVKDLTF 288 Query: 308 RGFWLSQWKKDHSPDQFKELILTLCDLIRRGQLTAP--ACSQVPLQDYQSALEAS 360 R I + L+ G+L +PL++ E Sbjct: 289 R----------IGLANVHLYIDAVLALLASGRLQPERIVSHYLPLEEAPRGYELF 333 >4DVJ-A nrPDB Length = 363 Score = 164 bits (414), Expect = 8e-41, Method: Composition-based stats. Identities = 70/345 (20%), Positives = 124/345 (35%), Gaps = 23/345 (6%) Query: 41 ARVRALVYGHHGDPAKVVELKNLELAAVRG--SDVRVKMLAAPINPSDINMIQGNYGFLP 98 ++A+ Y L ++EL D+ V++ A +NP D + + Sbjct: 21 QSMKAVGYNKPAPITDDASLLDIELPKPAPAGHDILVEVKAVSVNPVDYKVRRSTPPDGT 80 Query: 99 ELPAVGGNEGVAQVVAVGSNVTGLKPGDWVIPANAGL--GTWRTEAVFSEEALIQVPSDI 156 + V G + V AVG +VT +PGD V A + + GT + E + + P + Sbjct: 81 DW-KVIGYDAAGIVSAVGPDVTLFRPGDEVFYAGSIIRPGTNAEFHLVDERIVGRKPKTL 139 Query: 157 PLQSAATLGVNPCTAYRMLMDFEQLQ---PG--DSVIQNASNSGVGQAVIQIAAALGLRT 211 AA L + TA+ D + PG +++ GVG +QIA T Sbjct: 140 DWAEAAALPLTSITAWEAFFDRLDVNKPVPGAAPAILIVGGAGGVGSIAVQIARQRTDLT 199 Query: 212 INVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFFKDMPQPRLALNCVGGKSSTE 271 + RP+ Q + +KSLGA HVI + E+ P + K + E Sbjct: 200 VIATASRPETQ---EWVKSLGAHHVIDHSKPLAAEVAALGLGAPAFVFSTTHT-DKHAAE 255 Query: 272 LLRQLARGGTMVTYGGMAKQPVVASVSLLIFKDLKLRGFWLSQ--WKKDHSPDQFKELIL 329 + +A G P + L K + + + + L+ Sbjct: 256 IADLIAPQGRFCLI----DDPSAFDIMLFKRKAVSIHHELMFTRPMFGTPDMSEQGRLLN 311 Query: 330 TLCDLIRRGQLTAPACSQV-PLQDY--QSALEASMKPFISSKQIL 371 + L+ G+L +++ P+ + A K ++ Sbjct: 312 DVSRLVDEGRLRTTLTNRLSPINAANLKQAHALVESGTARGKVVI 356 >1YQX-A nrPDB Length = 366 Score = 163 bits (412), Expect = 1e-40, Method: Composition-based stats. Identities = 70/329 (21%), Positives = 115/329 (34%), Gaps = 51/329 (15%) Query: 25 GCHGPAASSYSASAEPARVRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINP 84 G HG S S E V+A D + + N A DVR K+L + Sbjct: 1 GSHG---MSKSPEEE-HPVKAFG-WAARDQSGHLSPFNFSRRATGEEDVRFKVLYCGVCH 55 Query: 85 SDINMIQGNYGFLPELPAVGGNEGVAQVVAVGSNVTGLKPGDWV-IPANAG--------- 134 SD++ I+ ++GF P V G+E V +V VGS V + GD V + G Sbjct: 56 SDLHSIKNDWGFSM-YPLVPGHEIVGEVTEVGSKVKKVNVGDKVGVGCLVGACHSCESCA 114 Query: 135 ------------------------LGTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCT 170 G + V +E +I+ P ++PL A L T Sbjct: 115 NDLENYCPKMILTYASIYHDGTITYGGYSNHMVANERYIIRFPDNMPLDGGAPLLCAGIT 174 Query: 171 AYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKS 230 Y L F +PG + ++ A A G + + V+ P K + LK+ Sbjct: 175 VYSPLKYFGLDEPGKHIGIVGLGGLG-HVAVKFAKAFGSK-VTVISTSP--SKKEEALKN 230 Query: 231 LGAEHVITEEELRRPEMKNFFKDMPQPRLALNCVGG-KSSTELLRQLARGGTMVTYGGMA 289 GA+ + + + ++ V L L G ++ G Sbjct: 231 FGADSFLVSRDQ-----EQMQAAAGTLDGIIDTVSAVHPLLPLFGLLKSHGKLILVGAPE 285 Query: 290 KQPVVASVSLLIFKDLKLRGFWLSQWKKD 318 K + + SL+ + + + G + K+ Sbjct: 286 KPLELPAFSLIAGRKI-VAGSGIGGMKET 313 >3GFB-A nrPDB Length = 350 Score = 156 bits (395), Expect = 1e-38, Method: Composition-based stats. Identities = 67/351 (19%), Positives = 129/351 (36%), Gaps = 54/351 (15%) Query: 42 RVRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQ-GNYGFLP-E 99 +++A++ PA EL +++ +V +K+LA I +D+++ + + + Sbjct: 4 KMQAIMKT---KPAYGAELVEVDVPKPGPGEVLIKVLATSICGTDLHIYEWNEWAQSRIK 60 Query: 100 LPAVGGNEGVAQVVAVGSNVTGLKPGDWVIPANAGLGT---------------------- 137 P + G+E +VV VG V L+ GD++ + Sbjct: 61 PPQIMGHEVAGEVVEVGPGVEDLQVGDYISVETHIVCGKCYACKHNRYHVCQNTKIFGVD 120 Query: 138 ----WRTEAVFSEEALIQVPSDIPLQSAA---TLGVNPCTAYRMLMDFEQLQPGDSVIQN 190 + A+ + + P D+P + AA LG T G S + Sbjct: 121 MDGVFAHYAIVPAKNAWKNPKDMPPEYAALQEPLGNAVDTV------LAGPIAGRSTLIT 174 Query: 191 ASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNF 250 + +G I +A A G + V +KL K +GA++V+ E + Sbjct: 175 GAGP-LGLLGIAVAKASGAYPVIVSEPSEFRRKL---AKKVGADYVVNPFEEDPVKFVMD 230 Query: 251 FKDMPQPRLALNCVGG-KSSTELLRQLARGGTMVTYGGMAKQPVVASVSLLIFKDLKLRG 309 D + L G K+ + L+ + GG + G ++ + +L+IFK L++ G Sbjct: 231 ITDGAGVEVFLEFSGAPKALEQGLKAVTPGGRVSLLGLFPREVTIDFNNLIIFKALEVHG 290 Query: 310 FWLSQWKKDHSPDQFKELILTLCDLIRRGQLTAPACSQVPLQDYQSALEAS 360 H + + + LI+ G+L + + EA Sbjct: 291 IT-----GRHLWETWYTVS----SLIQSGKLNLDPIITHKYKGFDKFEEAF 332 >2DFV-A nrPDB Length = 347 Score = 154 bits (390), Expect = 4e-38, Method: Composition-based stats. Identities = 65/355 (18%), Positives = 124/355 (34%), Gaps = 53/355 (14%) Query: 53 DPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQ-GNYGFLP-ELPAVGGNEGVA 110 P EL +++ +V +K+LA I +D+++ + + + P + G+E Sbjct: 11 KPGYGAELVEVDVPKPGPGEVLIKVLATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAG 70 Query: 111 QVVAVGSNVTGLKPGDWVIPANAGLGT--------------------------WRTEAVF 144 +VV +G V G++ GD+V + + AV Sbjct: 71 EVVEIGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDTDGVFAEYAVV 130 Query: 145 SEEALIQVPSDIPLQSAA---TLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVI 201 + + + P IP + A LG T G SV+ + +G I Sbjct: 131 PAQNIWKNPKSIPPEYATLQEPLGNAVDTV------LAGPISGKSVLITGAGP-LGLLGI 183 Query: 202 QIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFFKDMPQPRLAL 261 +A A G + V + K +GA++VI E + D + L Sbjct: 184 AVAKASGAYPVIV---SEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDVFL 240 Query: 262 NCVGG-KSSTELLRQLARGGTMVTYGGMAKQPVVASVSLLIFKDLKLRGFWLSQWKKDHS 320 G K+ + L+ + G + G + + +L+IFK L + G H Sbjct: 241 EFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVTIDFNNLIIFKALTIYGIT-----GRHL 295 Query: 321 PDQFKELILTLCDLIRRGQLTAPACSQVPLQDYQSALEAS--MKPFISSKQILTM 373 + + + L++ G+L + + EA M+ + K + + Sbjct: 296 WETWYTVS----RLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKVVFML 346 >4A10-A nrPDB Length = 447 Score = 154 bits (389), Expect = 6e-38, Method: Composition-based stats. Identities = 73/363 (20%), Positives = 116/363 (31%), Gaps = 76/363 (20%) Query: 56 KVVELKNLELAAVRGSDVRVKMLAAPINPSDI----------------NMIQGNYGFLPE 99 K + L + + + +V V ++A+ IN + + N QG + + Sbjct: 48 KSLRLGEVPMPELAPDEVLVAVMASSINYNTVWSAMFEPIPTFHFLKQNARQGGWATRHD 107 Query: 100 LPA-VGGNEGVAQVVAVGSNVTGLKPGDWV--------------------------IPAN 132 P V G++ VV G V KPGD V Sbjct: 108 QPYHVLGSDCSGVVVRTGIGVRRWKPGDHVIVHPAHVDEQEPATHGDGMLGTEQRAWGFE 167 Query: 133 AGLGTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYRMLM--DFEQLQPGDSVIQN 190 G V L+ P+ + + AA + TAYRML+ Q++ GD V+ Sbjct: 168 TNFGGLAEYGVVRASQLLPKPAHLTWEEAAVSPLCAGTAYRMLVSDRGAQMKQGDIVLIW 227 Query: 191 ASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEEL-------- 242 ++ G+G IQ G + VV + +++LG + VI EL Sbjct: 228 GASGGLGSYAIQFVKNGGGIPVAVVSS----AQKEAAVRALGCDLVINRAELGITDDIAD 283 Query: 243 ---------RRPEMKNFFKDMPQPRLALNCVGGKSSTELLRQLARGGTMVTYGGMAKQPV 293 R+ K +P + G + + RGGT+VT G + Sbjct: 284 DPRRVVETGRKLAKLVVEKAGREPDIVFEHTGRVTFGLSVIVARRGGTVVTCGSSSGYLH 343 Query: 294 VASVSLLIFKDLKLRGFWLSQWKKDHSPDQFKELILTLCDLIRRGQLTAPACSQVPLQDY 353 L K K+ G S E L G + + PL + Sbjct: 344 TFDNRYLWMKLKKIVG----------SHGANHEEQQATNRLFESGAVVPAMSAVYPLAEA 393 Query: 354 QSA 356 A Sbjct: 394 AEA 396 >4GKV-A nrPDB Length = 336 Score = 152 bits (385), Expect = 2e-37, Method: Composition-based stats. Identities = 51/357 (14%), Positives = 119/357 (33%), Gaps = 53/357 (14%) Query: 43 VRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPELPA 102 ++A V D V K L +++ + +KM + +D+++ G++G Sbjct: 1 MKAAVVTK--DHHVDVTYKTL--RSLKHGEALLKMECCGVCHTDLHVKNGDFGDKTG--V 54 Query: 103 VGGNEGVAQVVAVGSNVTGLKPGDWVIPA---------------------------NAGL 135 + G+EG+ V VG VT LKPGD A + Sbjct: 55 ILGHEGIGVVAEVGPGVTSLKPGDRASVAWFYEGCGHCEYCNSGNETLCRSVKNAGYSVD 114 Query: 136 GTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSG 195 G E + + ++VP + +A+++ T Y+ + +++PG + Sbjct: 115 GGMAEECIVVADYAVKVPDGLDSAAASSITCAGVTTYKAV-KLSKIRPGQWIAIYGLGGL 173 Query: 196 VGQAVIQIAA-ALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFFKDM 254 +Q A + I + + ++ ++ +GA+ I ++ Sbjct: 174 G-NLALQYAKNVFNAKVIAIDVNDEQLKLATE----MGADLAINSHTEDAAKIVQEKTGG 228 Query: 255 PQPRLALNCVGGKSSTELLRQLARGGTMVTYGGMAKQPVVASVSLLIFKDLKLRGFWLSQ 314 + + + + GG +V G + + L+ +++ G + Sbjct: 229 AHAAVVTAVA-KAAFNSAVDAVRAGGRVVAVGLPPESM-SLDIPRLVLDGIEVVGSLVGT 286 Query: 315 WKKDHSPDQFKELILTLCDLIRRGQLTAPACSQVPLQDYQSALEASMKPFISSKQIL 371 ++ + G++ + PL D + + I + ++ Sbjct: 287 ----------RQDLTEAFQFAAEGKVVPKVALR-PLADINTIFTEMEEGKIRGRMVI 332 >5VKT-A nrPDB Length = 362 Score = 151 bits (382), Expect = 4e-37, Method: Composition-based stats. Identities = 62/309 (20%), Positives = 109/309 (35%), Gaps = 48/309 (15%) Query: 43 VRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPELPA 102 + D + + + +DV +K+L I +D+++I+ +G P Sbjct: 7 CKTAHGWAARDASGHLSPYSFSARIQGDADVTIKVLFCGICHTDLHVIKNEWGN-AMYPV 65 Query: 103 VGGNEGVAQVVAVGSNVTGLKPGDWV--------------------------IPANAGL- 135 V G+E V V VG VT K GD V + + G+ Sbjct: 66 VPGHEVVGVVTDVGHGVTKFKAGDTVGVGYFVDSCRTCESCSTGHENYCPDLVLTSNGVD 125 Query: 136 ---------GTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDS 186 G + V S++ +++VP +PL AA L T Y + + +PG Sbjct: 126 HHHHGATTKGGFSDVLVVSQDFVVRVPESLPLDGAAPLLCAGVTVYSPMAQYALNEPGKH 185 Query: 187 VIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPE 246 + ++ A A G+ T+ V+ P K + L LGA+ + + + + Sbjct: 186 LGVVGLGGLG-HMAVKFAKAFGM-TVTVISSSPG--KRDEALGRLGADAFLVSHDAAQMK 241 Query: 247 MKNFFKDMPQPRLALNCV-GGKSSTELLRQLARGGTMVTYGGMAKQPVVASVSLLIFKDL 305 D ++ V G LL L G MV G + P+ +I Sbjct: 242 AAAATLDG-----IIDTVSAGHQIVPLLALLKPMGQMVVVGAPST-PLELPAYAIITGGK 295 Query: 306 KLRGFWLSQ 314 ++ G + Sbjct: 296 RVAGNGVGS 304 >5Z0C-A nrPDB Length = 374 Score = 149 bits (377), Expect = 1e-36, Method: Composition-based stats. Identities = 73/368 (19%), Positives = 122/368 (33%), Gaps = 58/368 (15%) Query: 39 EPARVRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLP 98 E V+A+ DP+ + A DV K+L I SD++ I+ + Sbjct: 8 EEHTVKAVG-WAARDPSGHLSPFTFSRRATGELDVTFKVLYCGICHSDLHYIKNEWSNTI 66 Query: 99 ELPAVGGNEGVAQVVAVGSNVTGLKPGDWV------------------------------ 128 PA+ G+E V +V VGS V K GD V Sbjct: 67 -YPALPGHEIVGEVTEVGSKVNKFKVGDKVGVGCIVGSCHSCPNCNNHLENYCPNRILTF 125 Query: 129 ----IPANAGLGTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPG 184 G + V E +++P +PL SAA L T Y L + +PG Sbjct: 126 GSRYYDGTLNHGGYSDLMVVQEHFAVRIPDALPLDSAAPLLCAGITVYSPLRYYGLDKPG 185 Query: 185 DSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRR 244 V ++ A A G++ + VV P K D + LGA I + Sbjct: 186 LHVGVVGLGGLG-HMAVKFAKAFGVK-VTVVSTSP--AKKEDAISGLGAHSFILSTD--- 238 Query: 245 PEMKNFFKDMPQPRLALNCVGGKS-STELLRQLARGGTMVTYGGMAKQPVVASVSLLIFK 303 + + ++ V L+ L G +V G K P+ V L+ Sbjct: 239 --AEQMQAAVGTMDGIIDTVSASHPLPPLISLLKSHGKLVMVGDPPK-PLELPVFPLLLG 295 Query: 304 DLKLRGFWLSQWKKDHSPDQFKELILTLCDLIRRGQLTAPACSQVPLQDYQSALEASMKP 363 + G + K+ + D + + A +P+ +A++ K Sbjct: 296 RKMVAGSAIGGMKETQ----------EMIDFAAKEGVRADV-EVIPMDYVNTAMQRVSKS 344 Query: 364 FISSKQIL 371 + + ++ Sbjct: 345 DVKYRFVI 352 >1UUF-A nrPDB Length = 369 Score = 149 bits (376), Expect = 2e-36, Method: Composition-based stats. Identities = 60/311 (19%), Positives = 103/311 (33%), Gaps = 54/311 (17%) Query: 42 RVRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPELP 101 +++A+ P +E ++ +DV++++ + SD++ ++ + P Sbjct: 22 KIKAVGAYSAKQP---LEPMDITRREPGPNDVKIEIAYCGVCHSDLHQVRSEWAGTV-YP 77 Query: 102 AVGGNEGVAQVVAVGSNVTGLKPGDWVIPAN----------------------------- 132 V G+E V +VVAVG V PGD V Sbjct: 78 CVPGHEIVGRVVAVGDQVEKYAPGDLVGVGCIVDSCKHCEECEDGLENYCDHMTGTYNSP 137 Query: 133 ------AGLGTWRTEAVFSEEALIQV-PSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGD 185 LG + + V E ++++ L + A L T Y L + Q G Sbjct: 138 TPDEPGHTLGGYSQQIVVHERYVLRIRHPQEQLAAVAPLLCAGITTYSPLRHW---QAGP 194 Query: 186 -SVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRR 244 + G+G I++A A+G + + K+LGA+ V+ Sbjct: 195 GKKVGVVGIGGLGHMGIKLAHAMGAHVVAFTTSEAKR----EAAKALGADEVVNSRNAD- 249 Query: 245 PEMKNFFKDMPQPRLALNCVGGK-SSTELLRQLARGGTMVTYGGMAKQPVVASVSLLIFK 303 + LN V + + L R GTM G A V LI K Sbjct: 250 ----EMAAHLKSFDFILNTVAAPHNLDDFTTLLKRDGTMTLVGAPATPHKSPEVFNLIMK 305 Query: 304 DLKLRGFWLSQ 314 + G + Sbjct: 306 RRAIAGSMIGG 316 >1F8F-A nrPDB Length = 371 Score = 146 bits (369), Expect = 1e-35, Method: Composition-based stats. Identities = 69/357 (19%), Positives = 117/357 (32%), Gaps = 65/357 (18%) Query: 58 VELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPELPAVGGNEGVAQVVAVGS 117 EL+ L++ +G +V VK++A + +D+ + Y LPAV G+EG + A+G Sbjct: 19 FELQALKIRQPQGDEVLVKVVATGMCHTDLIVRDQKYPVP--LPAVLGHEGSGIIEAIGP 76 Query: 118 NVTGLKPGDWVIPANAGLG----------------------------------------- 136 NVT L+ GD V+ + G Sbjct: 77 NVTELQVGDHVVLSYGYCGKCTQCNTGNPAYCSEFFGRNFSGADSEGNHALCTHDQGVVN 136 Query: 137 -------TWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQ 189 ++ T A+ E ++V D+P++ LG T ++ ++ P S + Sbjct: 137 DHFFAQSSFATYALSRENNTVKVTKDVPIELLGPLGCGIQTGAGACINALKVTPASSFVT 196 Query: 190 NASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKN 249 + VG + + A G I V ++ + K LGA HVI + Sbjct: 197 WGA-GAVGLSALLAAKVCGASIIIAVDI---VESRLELAKQLGATHVINSKTQDPVAAIK 252 Query: 250 FFKDMPQPRLALNCVGGKS-STELLRQLARGGTMVTYGGM-AKQPVVASVSLLIFKDLKL 307 D AL G + + L G + G V+ L+ + Sbjct: 253 EITDG-GVNFALESTGSPEILKQGVDALGILGKIAVVGAPQLGTTAQFDVNDLLLGGKTI 311 Query: 308 RGFWLSQWKKDHSPDQFKELILTLCDLIRRGQLTAP-ACSQVPLQDYQSALEASMKP 363 G K+ I L L ++G+ + A S K Sbjct: 312 LGVVEGS-------GSPKKFIPELVRLYQQGKFPFDQLVKFYAFDEINQAAIDSRKG 361 >2H6E-A nrPDB Length = 344 Score = 144 bits (363), Expect = 5e-35, Method: Composition-based stats. Identities = 69/365 (18%), Positives = 133/365 (36%), Gaps = 58/365 (15%) Query: 42 RVRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQG-NYGFLPEL 100 + +A + +P + ++++ + +G +V +++ A + +D+ + +G L Sbjct: 3 KSKAALLKKFSEP---LSIEDVNIPEPQGEEVLIRIGGAGVCRTDLRVWKGVEAKQGFRL 59 Query: 101 PAVGGNEGVAQVVAVGSNVTGLKPGD--------------------------WVIPANAG 134 P + G+E +V VG +K GD +IP Sbjct: 60 PIILGHENAGTIVEVGELAK-VKKGDNVVVYATWGDLTCRYCREGKFNICKNQIIPGQTT 118 Query: 135 LGTWRTEAVF-SEEALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQL--QPGDSVIQNA 191 G + + S L+++ + + AA L T+ + + + V+ Sbjct: 119 NGGFSEYMLVKSSRWLVKL-NSLSPVEAAPLADAGTTSMGAIRQALPFISKFAEPVVIVN 177 Query: 192 SNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFF 251 G+ IQI AL V R K D LGA++V ++ + N Sbjct: 178 GIGGLAVYTIQILKALMKNITIVGISRSK--KHRDFALELGADYVSEMKDAE--SLINKL 233 Query: 252 KDMPQPRLALNCVGGKSSTELLRQ-LARGGTMVTYGGMAKQPVVASVSLLIFKDLKLRGF 310 D +A++ VG + +T L + LA+ G ++ G K + L F Sbjct: 234 TDGLGASIAIDLVGTEETTYNLGKLLAQEGAIILVGMEG-------------KRVSLEAF 280 Query: 311 WLSQWKKDHSPDQFKELILTLCDLIR---RGQLTAPACSQVPLQDYQSALEASMKPFISS 367 + W K + L L D++R G++ VPL D A + + Sbjct: 281 DTAVWNKKLLGSNYGSLND-LEDVVRLSESGKIKPYIIK-VPLDDINKAFTNLDEGRVDG 338 Query: 368 KQILT 372 +Q++T Sbjct: 339 RQVIT 343 >5VM2-A nrPDB Length = 347 Score = 143 bits (361), Expect = 9e-35, Method: Composition-based stats. Identities = 55/338 (16%), Positives = 106/338 (31%), Gaps = 47/338 (13%) Query: 58 VELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPELP---AVGGNEGVAQVVA 114 +++ + E+ + +V +K+ I SD++ + P+ P G+E VVA Sbjct: 14 MKIISAEIPVPKEDEVLIKVEYVGICGSDVHGFESGPFIPPKDPNQEIGLGHECAGTVVA 73 Query: 115 VGSNVTGLKPGDWV-----IPANAGL-----------------------GTWRTEAVFSE 146 VGS V KPGD V +P G E Sbjct: 74 VGSRVRKFKPGDRVNIEPGVPCGHCRYCLEGKYNICPDVDFMATQPNYRGALTHYLCHPE 133 Query: 147 EALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAA 206 ++P ++ + + + ++PG +I + +G +Q Sbjct: 134 SFTYKLPDNMDTMEGTLVEPAAVGMHAAM--LADVKPGKKIIILGA-GCIGLMTLQACKC 190 Query: 207 LGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFFKDMPQPRLALNCVGG 266 LG I VV +++ LGA VI + F + + G Sbjct: 191 LGATEIAVVDVLEKRLAMAE---QLGATVVINGAKEDTIARCQQFTEDMGADIVFETAGS 247 Query: 267 KSSTELLRQLARGGTMVTYGGMAKQPVVASVSLLIFKDLKLRGFWLSQWKKDHSPDQFKE 326 + + L G + G + L I +++ ++ + + P + Sbjct: 248 AVTVKQAPYLVMRGGKIMIVGTVPGASAIN-FLKINREVTIQTVFRY---ANRYPVTIEA 303 Query: 327 LILTLCDLIRRGQLTAPACSQVPLQDYQSALEASMKPF 364 + D + + +D Q A E S+ Sbjct: 304 ISSGRFD------VKSMVTHIYDYRDVQQAFEESVNNK 335 >5TNX-A nrPDB Length = 383 Score = 142 bits (358), Expect = 2e-34, Method: Composition-based stats. Identities = 73/358 (20%), Positives = 115/358 (32%), Gaps = 65/358 (18%) Query: 57 VVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPELPAVGGNEGVAQVVAVG 116 ++ + A RG +V V+++A + +D+ + Y LPAV G+EG V AVG Sbjct: 29 PFSIEPARIRAPRGDEVLVRVVATGLCHTDLIVRDQYYPVP--LPAVLGHEGAGVVEAVG 86 Query: 117 SNVTGLKPGDWVIPANAGLG---------------------------------------- 136 NV L GD V+ G Sbjct: 87 PNVKTLAAGDHVVLTYGACGHCASCAGGHGAYCRQFFALNFGGADADGQTALRDAAGEPL 146 Query: 137 --------TWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVI 188 ++ + A+ E I+VP + PL+ LG T +++ ++ G S Sbjct: 147 HDHFFAQSSFASYALARENNAIKVPKEAPLELLGPLGCGIQTGAGAVINSLAVRTGSSF- 205 Query: 189 QNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMK 248 + VG + + A G TI V P L+ LGA H I +E+ + Sbjct: 206 ASFGAGAVGMSAVMAARIAGATTIIAVDIVPSRLALAL---ELGATHAINSKEVDVVDAI 262 Query: 249 NFFKDMPQPRLALNCVG-GKSSTELLRQLARGGTMVTYGGM-AKQPVVASVSLLIFKDLK 306 AL G ++ + L GTM G V+ L+ Sbjct: 263 REITGG-GVDYALESTGLPAVLSQGIDALGSRGTMGVVGAPKLGTKAEFDVNSLLLGGHT 321 Query: 307 LRGFWLSQWKKDHSPDQFKELILTLCDLIRRGQLTAP-ACSQVPLQDYQSALEASMKP 363 +RG + I L L +G+ PL+ A S Sbjct: 322 IRGIVEGD-------SVPQTFIPQLVQLHLQGRFPFDRLVKFYPLEQINQAAADSSSG 372 >4Y1B-A nrPDB Length = 425 Score = 139 bits (350), Expect = 2e-33, Method: Composition-based stats. Identities = 71/384 (18%), Positives = 122/384 (31%), Gaps = 80/384 (20%) Query: 40 PARVRALVYGH--HGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQG----- 92 P ++ A + +G P + +++ V V VK++AA +N +++ G Sbjct: 38 PKQMYASLIRQERYGRPVDAFRTEVVDVPPVGPGQVLVKVMAAGVNYNNVWAALGEPLDV 97 Query: 93 ----NYGFLPELPAVGGNEGVAQVVAVGSNVTGLKPG----------------------- 125 E +GG++ V AVG V LKPG Sbjct: 98 IAARQKQGATEDFHIGGSDLSGIVWAVGDGV-RLKPGAEVVVLACRWDESAQDIRLGADP 156 Query: 126 -----DWVIPANAGLGTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYRMLM--DF 178 V G++ AV E P + +A+ TAYR L + Sbjct: 157 VTSSTQRVWGYEENYGSFAQFAVVDEYMCHPKPQRLSWAAASCYMATAATAYRQLFGWEP 216 Query: 179 EQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVIT 238 ++PGD V+ G+G IQ+ +G + VV ++ + LGA+ I Sbjct: 217 HTVRPGDPVLIWGGAGGLGSIAIQLVRHVGGIPVAVVSS----EERGEFCMRLGAKGWID 272 Query: 239 EEEL----------RRPEMKNFFKDM--------------PQPRLALNCVGGKSSTELLR 274 E MK + PR+ L G + + Sbjct: 273 RREFDHWGRLPDTTDEEAMKQWLDGARAFGRRFWEVLGERRAPRIVLEHSGADTIPTSIY 332 Query: 275 QLARGGTMVTYGGMAKQPVVASVSLLIFKDLKLRGFWLSQWKKDHSPDQFKELILTLCDL 334 G +V GG + L + +L+G S + +E+ L Sbjct: 333 MADNAGMVVICGGTTGYNGDVDLRFLWMRQKRLQGS------HAASAREAREIT----RL 382 Query: 335 IRRGQLTAPACSQVPLQDYQSALE 358 I +G + ++ A + Sbjct: 383 IDQGAIDPCLSRTFGFEEIGLAHQ 406 >4OH1-A nrPDB Length = 351 Score = 137 bits (345), Expect = 7e-33, Method: Composition-based stats. Identities = 71/349 (20%), Positives = 123/349 (35%), Gaps = 53/349 (15%) Query: 58 VELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYG-----FLPELPAVGGNEGVAQV 112 V++ + + ++R+K++ A I SD +++ GN G LP G+E + Sbjct: 21 VDMMEAPMPEPKDEEIRIKVVYASICGSDTHILTGNLGEMESTTRSMLPMSFGHELSGVI 80 Query: 113 VAVGSNVT--GLKPGDWVIPANAGL----------------------GTWRTEAVFSEEA 148 VGS G K G V+ A + AV+ Sbjct: 81 DKVGSTAEKMGFKVGQKVVANYAKYCGCCENCREGKVNLCSNMGYRMNGFSEYAVYHMSQ 140 Query: 149 LIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALG 208 + +P D L+ A V P T + ++ G SV + G+G ++Q+A G Sbjct: 141 IFPIPDDADLKDYA--LVEPLTVALSSAEQAKISYGKSVAIMGA-GGLGMMLVQLARLAG 197 Query: 209 LRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFFKDMPQPRLALNCVGGKS 268 TI V + + + GA++ + E E L G + Sbjct: 198 ASTITVFDI---VPEKLELALENGADYALNSAEEGVAERAIELAGGRY-DCVLEGTGATA 253 Query: 269 STEL-LRQLARGGTMVTYGGMAKQPVVASVSL---LIFKDLKLRGFWLSQWKKDHSPDQF 324 + +L L+ LAR G V Y M + + V+L L + + G W+ S Sbjct: 254 AAKLGLQLLARDGDAV-YFAMYGKDPILPVNLQSDLYWDQKHIHGMIQGAWQFPKS---- 308 Query: 325 KELILTLCDLIRRGQLTAPACSQVPLQDYQSALEASMKPFISSKQILTM 373 +I R + + L +Y+ A E +K ++ M Sbjct: 309 -------IRMIPRMDFSKIIQKEHTLTNYKQAFEDLYSKK-YAKIVIKM 349 >1PL8-A nrPDB Length = 356 Score = 137 bits (344), Expect = 9e-33, Method: Composition-based stats. Identities = 63/360 (17%), Positives = 126/360 (35%), Gaps = 51/360 (14%) Query: 35 SASAEPARVRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQ-GN 93 +A+A+P + +LV GD + L+N + ++V ++M + I SD++ + G Sbjct: 1 AAAAKPNNL-SLVVHGPGD----LRLENYPIPEPGPNEVLLRMHSVGICGSDVHYWEYGR 55 Query: 94 YG-FLPELPAVGGNEGVAQVVAVGSNVTGLKPGDWVIPANAGLGTWRTEAVFSEEAL--- 149 G F+ + P V G+E V VGS+V LKPGD V L Sbjct: 56 IGNFIVKKPMVLGHEASGTVEKVGSSVKHLKPGDRVAIEPGAPRENDEFCKMGRYNLSPS 115 Query: 150 ------------------------IQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGD 185 ++P ++ + A + P + + G Sbjct: 116 IFFCATPPDDGNLCRFYKHNAAFCYKLPDNVTFEEGALI--EPLSVGIHACRRGGVTLGH 173 Query: 186 SVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRP 245 V+ + +G + +A A+G + V + K +GA+ V+ + Sbjct: 174 KVLVCGAGP-IGMVTLLVAKAMGAAQVVVTDLSAT---RLSKAKEIGADLVLQISKESPQ 229 Query: 246 EMKNFFKD--MPQPRLALNCVGGKSSTELLRQLARGGTMVTYGGMAKQPVVASVSLLIFK 303 E+ + +P + + C G ++S + R G + G+ + + + Sbjct: 230 EIARKVEGQLGCKPEVTIECTGAEASIQAGIYATRSGGTLVLVGLGSEMTTVPLLHAAIR 289 Query: 304 DLKLRGFWLSQWKKDHSPDQFKELILTLCDLIRRGQLTAPACSQVPLQDYQSALEASMKP 363 ++ ++G + + P L + + + PL+ A E K Sbjct: 290 EVDIKGVFRY---CNTWPVAISMLASKSVN------VKPLVTHRFPLEKALEAFETFKKG 340 >5GXF-A nrPDB Length = 330 Score = 136 bits (341), Expect = 2e-32, Method: Composition-based stats. Identities = 61/298 (20%), Positives = 111/298 (37%), Gaps = 16/298 (5%) Query: 60 LKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPELPAVGGNEGVAQVVAVGSNV 119 +K L L + +V V + + +N D I G + + P V G + V S+ Sbjct: 20 VKQLSLTDLPVGEVTVAVEYSTVNYKDGLCIGPGGGLVRKYPHVPGIDFAGTVEN--SSD 77 Query: 120 TGLKPGDWVIPANAGL-----GTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYRM 174 KPGD V+ + G + +A + L+ +P + + A +G TA Sbjct: 78 ERYKPGDKVVLTGWRVGEAHWGGYSQKANVRADWLVPLPEGLDTRQAMAVGTAGFTAMLA 137 Query: 175 LM--DFEQLQPGDS-VIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSL 231 +M + L PG V+ + GVG I A LG V + +D L SL Sbjct: 138 VMALEDHGLTPGHGPVLVTGAAGGVGSVATAILAHLGYEVAAVTG----RPETADYLTSL 193 Query: 232 GAEHVITEEELRRPEMKNFFKDMPQPRLALNCVGGKSSTELLRQLARGGTMVTYGGMAKQ 291 GA ++ +E+ + ++ + + VGG +L Q+ G ++ G Sbjct: 194 GATQIVARDEINETVKRPLESEIWAGCV--DAVGGAMLARVLGQMKYGASVAAVGLAGGA 251 Query: 292 PVVASVSLLIFKDLKLRGFWLSQWKKDHSPDQFKELILTLCDLIRRGQLTAPACSQVP 349 + A+V + + + L G + ++ + L + S +P Sbjct: 252 GLPATVIPFLLRGVNLLGIDSVMQPYANRLRAWERIARDLPMDKLEAMIRPATLSDLP 309 >4EJ6-A nrPDB Length = 370 Score = 134 bits (337), Expect = 6e-32, Method: Composition-based stats. Identities = 53/325 (16%), Positives = 118/325 (36%), Gaps = 42/325 (12%) Query: 43 VRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPELPA 102 ++A+ G+ + ++N+ + D+ VK+ A I +D +++ G + P P Sbjct: 24 MKAVRLESVGN----ISVRNVGIPEPGPDDLLVKVEACGICGTDRHLLHGEFPSTP--PV 77 Query: 103 VGGNEGVAQVVAVGSNVTGLKPGDWVIP--------------------------ANAGLG 136 G+E VV GS V + PG + G Sbjct: 78 TLGHEFCGIVVEAGSAVRDIAPGARITGDPNISCGRCPQCQAGRVNLCRNLRAIGIHRDG 137 Query: 137 TWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGV 196 + + + ++P + A P +D ++ G +V + Sbjct: 138 GFAEYVLVPRKQAFEIPLTLDPVHGAF--CEPLACCLHGVDLSGIKAGSTVAILG-GGVI 194 Query: 197 GQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFFKDM-- 254 G +Q+A G T+ + + ++L++ +GA + E + Sbjct: 195 GLLTVQLARLAGATTVILSTRQATKRRLAE---EVGATATVDPSAGDVVEAIAGPVGLVP 251 Query: 255 PQPRLALNCVGGKSSTELLRQLAR-GGTMVTYGGMAKQP-VVASVSLLIFKDLKLRGFWL 312 + + C G + + +LA+ GGT+V G + + V ++F++L++ G ++ Sbjct: 252 GGVDVVIECAGVAETVKQSTRLAKAGGTVVILGVLPQGEKVEIEPFDILFRELRVLGSFI 311 Query: 313 SQWKKDHSPDQFKELILTLCDLIRR 337 + + + D + + +I R Sbjct: 312 NPFVHRRAADLVATGAIEIDRMISR 336 >5H82-A nrPDB Length = 389 Score = 134 bits (336), Expect = 7e-32, Method: Composition-based stats. Identities = 64/385 (16%), Positives = 113/385 (29%), Gaps = 77/385 (20%) Query: 27 HGPAASSYSASAEPARVRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSD 86 GP++ S D + ++ DV+ K+L + D Sbjct: 17 QGPSSKSAKPVE-------AYGWAAKDTSGLLSPFKFLRRTTGEHDVQFKVLYCGLCDWD 69 Query: 87 INMIQGNYGFLPELPAVGGNEGVAQVVAVGSNVTGLKPGDWVIPANAG------------ 134 + + YG + P V G+E + V +G+ V K GD V N Sbjct: 70 VITTKNTYG-TTKYPFVPGHEIMGIVTEIGNKVKKFKVGDKVGVGNFIGSCGKCERCNEG 128 Query: 135 -----------------------------------LGTWRTEAVFSEEALIQVPSDIPLQ 159 G + V +E + + P ++PL Sbjct: 129 LEPYCPKVIYTDGTAFSDENNTVYGDVSGDGEDRIYGGYSNIMVANEYVVFRWPENLPLA 188 Query: 160 SAATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRP 219 + + Y + F +PG S+ +G+ ++ A A G + Sbjct: 189 AGVPILCGGIVPYSPMRHFGLDKPGLSIGVVG-FGRIGKLAVKFAKAFGANVTVISTS-- 245 Query: 220 DIQKLSDRLKSLGAEHVITEEELRRPEMKNFFKDMPQPRLALNCV-GGKSSTELLRQLAR 278 I K + ++ G + + +E + D +CV LL L Sbjct: 246 -ISKKQEAIEKYGVDRFLISKEPEEMKAAESTLDG-----IFDCVPSVHPLHPLLNLLKF 299 Query: 279 GGTMVTYGGMAKQPVVASVSLLIFKDLKLRGFWLSQWKKDHSPDQFKELILTLCDLIRRG 338 GT V G + VS L+ K G K+ + D + Sbjct: 300 EGTFVMLGVAVEA-YELPVSPLLMGRRKFVGSISGTMKETQ----------EMLDFAAKH 348 Query: 339 QLTAPACSQVPLQDYQSALEASMKP 363 + + +P+ +ALE K Sbjct: 349 NIVSDI-ELIPMDYVNTALERIAKG 372 >1E3J-A nrPDB Length = 352 Score = 130 bits (326), Expect = 1e-30, Method: Composition-based stats. Identities = 58/340 (17%), Positives = 118/340 (34%), Gaps = 53/340 (15%) Query: 58 VELKNLELAAVRGSDVRVKMLAAPINPSDINMIQ-GNY-GFLPELPAVGGNEGVAQVVAV 115 + L+ + + +V ++M I SD++ + G F+ + P V G+E VV V Sbjct: 16 LRLEQRPIPEPKEDEVLLQMAYVGICGSDVHYYEHGRIADFIVKDPMVIGHEASGTVVKV 75 Query: 116 GSNVTGLKPGDWV---------------------------IPANAGLGTWRTEAVFSEEA 148 G NV LK GD V G V + + Sbjct: 76 GKNVKHLKKGDRVAVEPGVPCRRCQFCKEGKYNLCPDLTFCATPPDDGNLARYYVHAADF 135 Query: 149 LIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALG 208 ++P ++ L+ A L P + +Q G +V+ + +G + A A G Sbjct: 136 CHKLPDNVSLEEGALL--EPLSVGVHACRRAGVQLGTTVLVIGAGP-IGLVSVLAAKAYG 192 Query: 209 LRTINVVRDRPDIQKLSDRLKSLGAEHVI---TEEELRRPEMKNFFKDMPQ-PRLALNCV 264 + R + + K+ GA+ + +E ++ + P + ++C Sbjct: 193 AFVVCTARS----PRRLEVAKNCGADVTLVVDPAKEEESSIIERIRSAIGDLPNVTIDCS 248 Query: 265 GGKSSTELLRQLARGGTMVTYGGMAKQPVVASVSLLIFKDLKLRGFWLSQWKKDHSPDQF 324 G + + + R G + GM Q V + +++ ++ + ++ D+ Sbjct: 249 GNEKCITIGINITRTGGTLMLVGMGSQMVTVPLVNACAREIDIKSVF--RYCNDYPI--- 303 Query: 325 KELILTLCDLIRRGQLTAP--ACSQVPLQDYQSALEASMK 362 +++ G+ L+ A EA+ K Sbjct: 304 ------ALEMVASGRCNVKQLVTHSFKLEQTVDAFEAARK 337 >3TWO-A nrPDB Length = 348 Score = 129 bits (323), Expect = 3e-30, Method: Composition-based stats. Identities = 65/318 (20%), Positives = 104/318 (32%), Gaps = 56/318 (17%) Query: 58 VELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPELPAVGGNEGVAQVVAVGS 117 + + AV DV + +L A I SDI+ + P + G+E + VG Sbjct: 17 FKPHDFSRHAVGPRDVLIDILYAGICHSDIHSAYSEWKEGI-YPMIPGHEIAGIIKEVGK 75 Query: 118 NVTGLKPGD--------------------------WVIPANAGL----------GTWRTE 141 V K GD V+ L G + Sbjct: 76 GVKKFKIGDVVGVGCFVNSCKACKPCKEHQEQFCTKVVFTYDCLDSFHDNEPHMGGYSNN 135 Query: 142 AVFSEEALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVI 201 V E +I V + PL+ A L T Y L F ++ G V A G+G + Sbjct: 136 IVVDENYVISVDKNAPLEKVAPLLCAGITTYSPL-KFSKVTKGTKVGV-AGFGGLGSMAV 193 Query: 202 QIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFFKDMPQPRLAL 261 + A A+G R+ Q S+G +H T+ + + E+ +P Sbjct: 194 KYAVAMGAEVSVFARNEHKKQDAL----SMGVKHFYTDPKQCKEELDFIISTIPTH---Y 246 Query: 262 NCVGGKSSTELLRQLARGGTMVTYGGM--AKQPVVASVSLLIFKDLKLRGFWLSQWKKDH 319 + + L+ L G + G PV++ + + K+ G + K+ Sbjct: 247 D------LKDYLKLLTYNGDLALVGLPPVEVAPVLSVFDFIHLGNRKVYGSLIGGIKETQ 300 Query: 320 SPDQF--KELILTLCDLI 335 F K I DLI Sbjct: 301 EMVDFSIKHNIYPEIDLI 318 >3QE3-A nrPDB Length = 355 Score = 128 bits (322), Expect = 3e-30, Method: Composition-based stats. Identities = 61/350 (17%), Positives = 118/350 (33%), Gaps = 50/350 (14%) Query: 45 ALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQ-GNYG-FLPELPA 102 +LV GD + L+N + ++V +KM + I SD++ Q G G F+ + P Sbjct: 9 SLVVHGPGD----LRLENYPIPEPGPNEVLLKMHSVGICGSDVHYWQHGRIGDFVVKKPM 64 Query: 103 VGGNEGVAQVVAVGSNVTGLKPGDWVIPANAGLGTWRTEAVFSEEAL------------- 149 V G+E VV VGS V L+PGD V L Sbjct: 65 VLGHEASGTVVKVGSLVRHLQPGDRVAIQPGAPRQTDEFCKIGRYNLSPTIFFCATPPDD 124 Query: 150 --------------IQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSG 195 ++P ++ + A + P + + G+ V+ + Sbjct: 125 GNLCRFYKHNANFCYKLPDNVTFEEGALI--EPLSVGIHACRRAGVTLGNKVLVCGAGP- 181 Query: 196 VGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFFKD-- 253 +G + A A+G + V + K +GA+ ++ E+ + Sbjct: 182 IGLVNLLAAKAMGAAQVVVTDLS---ASRLSKAKEVGADFILEISNESPEEIAKKVEGLL 238 Query: 254 MPQPRLALNCVGGKSSTELLRQLARGGTMVTYGGMAKQPVVASVSLLIFKDLKLRGFWLS 313 +P + + C G ++S + G + G+ + + +++ ++G + Sbjct: 239 GSKPEVTIECTGVETSIQAGIYATHSGGTLVLVGLGSEMTSVPLVHAATREVDIKGVFRY 298 Query: 314 QWKKDHSPDQFKELILTLCDLIRRGQLTAPACSQVPLQDYQSALEASMKP 363 + P L + + + PL+ A E S K Sbjct: 299 ---CNTWPMAISMLASKSVN------VKPLVTHRFPLEKALEAFETSKKG 339 >5KIA-A nrPDB Length = 351 Score = 128 bits (322), Expect = 4e-30, Method: Composition-based stats. Identities = 64/363 (17%), Positives = 120/363 (33%), Gaps = 59/363 (16%) Query: 43 VRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQ-GNYGFLPEL- 100 ++AL G + +K V +DV +K+ I +DI++ + ++ Sbjct: 9 MKALAKLERGPGLTLTRVKK---PEVGHNDVLIKIRRTAICGTDIHIWKWDDWAQKTIPV 65 Query: 101 PAVGGNEGVAQVVAVGSNVTGLKPGDWVIPANAGL------------------------- 135 P G+E V ++V +G V G GD V Sbjct: 66 PMHVGHEYVGEIVEMGQEVRGFSIGDRVSGEGHITCGFCRNCRAGRRHLCRNTVGVGVNR 125 Query: 136 -GTWRTEAVFSEEALIQVPSDIPLQSAA---TLGVNPCTAYRM-LMDFEQLQPGDSVIQN 190 G + ++P +I AA G TA L+ G+ V+ Sbjct: 126 EGAFAEYLAIPAFNAFKIPPEISDDLAAIFDPFGNATHTALSFNLV-------GEDVLIT 178 Query: 191 ASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNF 250 + +G + IA +G R + + D + +GA + ++ Sbjct: 179 GAGP-IGVMAVAIAKHVGARNVVITDIN---DYRLDLARRMGATRAVNVSRESLRDVMAD 234 Query: 251 FKDMPQPRLALNCVGGK-SSTELLRQLARGGTMVTYGGMAKQPVVASVSLLIFKDLKLRG 309 + L G + T LL + GG + G + + +IFK L+++G Sbjct: 235 LHMTEGFDVGLEMSGVPSAFTSLLESMNHGGKVALLG-IPPAQTAIDWNQVIFKGLEIKG 293 Query: 310 FWLSQWKKDHSPDQFKELILTLCDLIRRGQ-LTAPACSQVPLQDYQSALEASMKPFISSK 368 + + E + +++ G L+ + + DY+ A + S K Sbjct: 294 IY---------GREMFETWYKMVAMLQSGLDLSPIITHRFAVDDYEKGFAAMLSGE-SGK 343 Query: 369 QIL 371 IL Sbjct: 344 VIL 346 >5H83-A nrPDB Length = 360 Score = 127 bits (320), Expect = 6e-30, Method: Composition-based stats. Identities = 66/365 (18%), Positives = 115/365 (31%), Gaps = 63/365 (17%) Query: 28 GPAASSYSASAEPARVRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDI 87 GPAA S V+ + D + N A +DV+ K+L D+ Sbjct: 1 GPAAKS---PENVYPVKTFGFAAK-DSSGFFSPFNFSRRATGENDVQFKVLYCGTCNYDL 56 Query: 88 NMIQGNYGFLPELPAVGGNEGVAQVVAVGSNVTGLKPGDWVIP----------------- 130 M +G + P V G+E V V +GS V K GD V Sbjct: 57 EMSTNKFGMT-KYPFVIGHEIVGVVTEIGSKVQKFKVGDKVGVGGFVGACEKCEMCVNGV 115 Query: 131 -------------ANAGLGTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYRMLMD 177 G V +E+ + P ++PL S L T Y L Sbjct: 116 ENNCSKVESTDGHFGNNFGGCCNIMVVNEKYAVVWPENLPLHSGVPLLCAGITTYSPLRR 175 Query: 178 FEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVI 237 + +PG ++ I+ A A G + + ++K + L+ G + + Sbjct: 176 YGLDKPGLNIGIAGLGGLG-HLAIRFAKAFGAKVTLISSS---VKKKREALEKFGVDSFL 231 Query: 238 ---TEEELRRPEMKNFFKDMPQPRLALNCVGGKSS-TELLRQLARGGTMVTYGGMAKQPV 293 EE++ ++ + S L L G ++ G + Sbjct: 232 LNSNPEEMQGA--------YGTLDGIIDTMPVAHSIVPFLALLKPLGKLIILGVPEEPFE 283 Query: 294 VASVSLLIFKDLKLRGFWLSQWKKDHSPDQFKELILTLCDLIRRGQLTAPACSQVPLQDY 353 V + +LL+ + + KE + D + + A +P+ Sbjct: 284 VPAPALLMG----------GKLIAGSAAGSMKETQ-EMIDFAAKHNIVADV-EVIPIDYL 331 Query: 354 QSALE 358 +A+E Sbjct: 332 NTAME 336 >4OAQ-A nrPDB Length = 367 Score = 127 bits (318), Expect = 1e-29, Method: Composition-based stats. Identities = 60/339 (17%), Positives = 104/339 (30%), Gaps = 61/339 (17%) Query: 59 ELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPELPAVGGNEGVAQVVAVGSN 118 +L + E + DV +K + SDI+ + + L V G+E + +V+AVG Sbjct: 24 KLASYERKQINPHDVVLKNEVCGLCYSDIHTLSAGWQPLQRDNLVVGHEIIGEVIAVGDE 83 Query: 119 VTGLKPGDWVIPA------------------------------------NAGLGTWRTEA 142 VT K GD V G + + + Sbjct: 84 VTEFKVGDRVGIGAASSSCRSCQRCDSDNEQYCKQGAATYNSKDVRSNNYVTQGGYSSHS 143 Query: 143 VFSEEALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQP-GDSVIQNASNSGVGQAVI 201 + E+ + +P D+P A L T + L+ L G +V + Sbjct: 144 IADEKFVFAIPEDLPSSYGAPLMCAGITVFSPLIRNLGLDARGKNVGIIGIGGLG-HLAL 202 Query: 202 QIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFFKDMPQPRLAL 261 Q A A+G R ++ LGA + E + + L Sbjct: 203 QFANAMGANVTAFSRSSSK----KEQAMKLGAHDFVATGEDKT----WYKNYDDHFDFIL 254 Query: 262 NCVGGK---SSTELLRQLARGGTMVTYGGMAKQP-VVASVSLLIFKDLKLRGFWLSQWKK 317 NC G + +E L L V+ G + S + + L Sbjct: 255 NCASGIDGLNLSEYLSTLKVDKKFVSVGLPPSEDKFEVSPFTFLQQGASFGSSLLGS--- 311 Query: 318 DHSPDQFKELILTLCDLIRRGQLTAPACSQVPLQDYQSA 356 K + + +L + + P +VP+ + A Sbjct: 312 -------KTEVKEMLNLAAKHNVR-PMIEEVPISEENCA 342 >6FG0-A nrPDB Length = 352 Score = 126 bits (315), Expect = 2e-29, Method: Composition-based stats. Identities = 64/364 (17%), Positives = 115/364 (31%), Gaps = 54/364 (14%) Query: 43 VRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPE-LP 101 ++A+ Y G VV ++ ++ +K+ AA + SDI ++ LP Sbjct: 1 MKAVQYTEIGSEPVVV---DIPTPTPGPGEILLKVTAAGLCHSDITVMDMPAAQYAGGLP 57 Query: 102 AVGGNEGVAQVVAVGSNVTGLKPGDWV-IPANAGLGTW---------------------- 138 G+EGV V +G VTG GD V + G G Sbjct: 58 LTLGHEGVGTVAELGEGVTGFGVGDAVAVYGPWGCGACHACARGRENYCTRAADLGITPP 117 Query: 139 --------RTEAVFS-EEALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQ 189 + L+ + D+ +AA L T Y + L S Sbjct: 118 GYGSPGSMAEYMIVDSARHLVPI-GDLDPVAAAPLTDAGLTPYHAISRVLPLLGPGSTAV 176 Query: 190 NASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKN 249 G+G IQI A+ + V D L + +GA+ + ++ Sbjct: 177 VIGVGGLGHVGIQILRAVSAARVIAVDLDDDRLAL---AREVGADAAVKSGAGAADAIRE 233 Query: 250 FFKDMPQPRLALNCVGGKSSTELLRQ-LARGGTMVTYGGMAKQPVVASVSLLIFKDLKLR 308 + VG +S+ + +Q +A G + G A +I + Sbjct: 234 -LTGGQGATAVFDFVGAQSTIDTAQQVVAVDGHISVVGIHAGAHAKVG-FWMIPFGASVV 291 Query: 309 GFWLSQWKKDHSPDQFKELILTLCDLIRRGQLTAPACSQVPLQDYQSALEASMKPFISSK 368 + + + E++ L R G+L L + +A + I + Sbjct: 292 TPYWG------TRSELMEVVA----LARAGRLDIH-TETFTLDEGPAAYRRLREGSIRGR 340 Query: 369 QILT 372 ++ Sbjct: 341 GVVV 344 >4ILK-A nrPDB Length = 359 Score = 126 bits (315), Expect = 2e-29, Method: Composition-based stats. Identities = 57/305 (18%), Positives = 111/305 (36%), Gaps = 34/305 (11%) Query: 58 VELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPELPAVGGNEGVAQVVAVGS 117 + + E+ +VRVK+ A I SD ++ +G+ F + P V G+E + AVG Sbjct: 32 LSIIEREIPTPSAGEVRVKVKLAGICGSDSHIYRGHNPF-AKYPRVIGHEFFGVIDAVGE 90 Query: 118 NVTGLKPGDWV--------------------------IPANAGLGTWRTEAVFSEEALIQ 151 V + G+ V + G + AV + + Sbjct: 91 GVESARVGERVAVDPVVSCGHCYPCSIGKPNVCTTLAVLGVHADGGFSEYAVVPAKNAWK 150 Query: 152 VPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRT 211 +P + Q A + + P T + Q D+V+ + +G ++Q+ G+ Sbjct: 151 IPEAVADQYA--VMIEPFTIAANVTGHGQPTENDTVLVYGAGP-IGLTIVQVLK--GVYN 205 Query: 212 INVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFFKDMPQPRLALNCVGGKSSTE 271 + V I + ++ K GA+ I + P ++F + +P L ++ S + Sbjct: 206 VKNVIVADRIDERLEKAKESGADWAINNSQ--TPLGESFAEKGIKPTLIIDAACHPSILK 263 Query: 272 LLRQLARGGTMVTYGGMAKQPVVASVSLLIFKDLKLRGFWLSQWKKDHSPDQFKELILTL 331 LA + G + +P + K+L + L+ K D + ++ Sbjct: 264 EAVTLASPAARIVLMGFSSEPSEVIQQGITGKELSIFSSRLNANKFPVVIDWLSKGLIKP 323 Query: 332 CDLIR 336 LI Sbjct: 324 EKLIT 328 >5YLN-A nrPDB Length = 356 Score = 122 bits (305), Expect = 3e-28, Method: Composition-based stats. Identities = 57/353 (16%), Positives = 122/353 (34%), Gaps = 52/353 (14%) Query: 43 VRALVYGHHGDPAKVVELKNLELAAV-RGSDVRVKMLAAPINPSDINMIQGNYGFLPELP 101 ++A Y G + +++ + + +D V+++ I +D+++I+G+ Sbjct: 5 MKAYTYVKPG----LASFVDVDKPVIRKPTDAIVRIVKTTICGTDLHIIKGDVPTCQSG- 59 Query: 102 AVGGNEGVAQVVAVGSNVTGLKPGDWVIPANAGL------------------GTW----- 138 + G+EG+ V VG V+ K GD V+ + G W Sbjct: 60 TILGHEGIGIVEEVGEGVSNFKKGDKVLISCVCACGKCYYCKKGIYAHCEDEGGWIFGHL 119 Query: 139 -----RTEAVFS--EEALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNA 191 + L P D+ ++ L T Y + + +++PG SV Sbjct: 120 IDGMQAEYLRVPHADNTLYHTPEDLSDEALVMLSDILPTGYEIGVLKGKVEPGCSVAIIG 179 Query: 192 SNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNF- 250 + VG A + A + +V + + S GA H + + + + + Sbjct: 180 -SGPVGLAALLTAQFYSPAKLIMVDLDDN---RLETALSFGATHKVNSSDPEKAIKEIYD 235 Query: 251 FKDMPQPRLALNCVGGKSSTELL-RQLARGGTMVTYGGMAKQPVVASVSLLIFKDLKLRG 309 D +A+ VG ++ + + + GT+ G + +PV + L +++ + Sbjct: 236 LTDGRGVDVAIEAVGIPATFDFCQKIIGVDGTVANCG-VHGKPVEFDLDKLWIRNINVTT 294 Query: 310 FWLSQWKKDHSPDQFKELILTLCDLIRRGQLTAPACSQVPLQDYQSALEASMK 362 +S + + L+ L + + A E K Sbjct: 295 GLVSTNTTPQLLKALESHKIEPEKLVTH---------YFKLSEIEKAYEVFSK 338 >2DQ4-A nrPDB Length = 343 Score = 121 bits (303), Expect = 6e-28, Method: Composition-based stats. Identities = 61/344 (17%), Positives = 106/344 (30%), Gaps = 54/344 (15%) Query: 54 PAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQ--GNYGFLPELPAVGGNEGVAQ 111 P + + L + + ++ V++ AA I +D+++ + P V G+E Sbjct: 9 PEEGLTLVDRPVPEPGPGEILVRVEAASICGTDLHIWKWDAWARGRIRPPLVTGHEFSGV 68 Query: 112 VVAVGSNVTGLKPGDWV-----IPANAGL---------------------GTWRTEAVFS 145 V AVG V + GD V I +A G + V Sbjct: 69 VEAVGPGVRRPQVGDHVSLESHIVCHACPACRTGNYHVCLNTQILGVDRDGGFAEYVVVP 128 Query: 146 EEALIQVPSDIPLQSAA---TLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQ 202 E P D+P + AA G T Y G SV+ + +G Sbjct: 129 AENAWVNPKDLPFEVAAILEPFGNAVHTVY-----AGSGVSGKSVLITGAGP-IGLMAAM 182 Query: 203 IAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFFKDMPQPRLALN 262 + A G I V P + A+ ++ E E+ + L Sbjct: 183 VVRASGAGPILVSDPNPYRLAFARPY----ADRLVNPLEEDLLEVVRRVTG-SGVEVLLE 237 Query: 263 CVGGKSST-ELLRQLARGGTMVTYGGMAKQPVVASVSLLIFKDLKLRGFWLSQWKKDHSP 321 G +++ + L L GG G + + +L +RG Sbjct: 238 FSGNEAAIHQGLMALIPGGEARILG-----IPSDPIRFDLAGELVMRGITAFGIAGRRLW 292 Query: 322 DQFKELILTLCDLIRRGQ--LTAPACSQVPLQDYQSALEASMKP 363 + + L+ G+ L+ ++PL Y+ A Sbjct: 293 QTWMQGTA----LVYSGRVDLSPLLTHRLPLSRYREAFGLLASG 332 >6C49-A nrPDB Length = 350 Score = 120 bits (301), Expect = 8e-28, Method: Composition-based stats. Identities = 68/359 (18%), Positives = 125/359 (34%), Gaps = 56/359 (15%) Query: 42 RVRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPELP 101 ++A G+ + + ++ V VK+ + SDI+++ + P Sbjct: 13 TIQAYAAMQAGEKLVPYK---FDAGELQPHQVEVKVEYCGLCHSDISVLNNEWHSTV-YP 68 Query: 102 AVGGNEGVAQVVAVGSNVTGLKPGDWV---IPANAGL----------------------- 135 V G+E + ++VA+GS GL+ G V A + Sbjct: 69 VVAGHEIIGRIVALGSEAKGLQIGQRVGIGWTAESCQACDECIGGQQVLCTGENIATIVG 128 Query: 136 --GTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNASN 193 G + + + I +P D+ +SA L T + L+ ++Q V Sbjct: 129 HAGGFADKVRAGWQWAIPLPEDLDPESAGPLLCGGITVFDPLLK-HKIQATHHVGVIGIG 187 Query: 194 SGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFFKD 253 I++ A G I PD ++ LK++GA+HV+ + + + Sbjct: 188 GLG-HIAIKLLKAWGCE-ITAFSSNPD---KTEELKAMGADHVVNSRDTEAVKAQK---- 238 Query: 254 MPQPRLALNCVGGK-SSTELLRQLARGGTMVTYGGMAKQPVVASVSLLIFKDLKLRGFWL 312 + L L+ V + + LA G++ G +PV SV LI + G Sbjct: 239 -GKFDLLLSTVNVTLNWRAFISTLAPNGSLHFLGLTL-EPVPVSVGSLIDGAKSVTGSPT 296 Query: 313 SQWKKDHSPDQFKELILTLCDLIRRGQLTAPACSQVPLQDYQSALEASMKPFISSKQIL 371 SP ++ L R ++ AP P+ A+E + +L Sbjct: 297 G------SPAALRQ----LLKFAARKKI-APQIELFPMSQLNEAIERLHSGQARYRIVL 344 >1Q1N-A nrPDB Length = 360 Score = 117 bits (292), Expect = 1e-26, Method: Composition-based stats. Identities = 70/374 (18%), Positives = 119/374 (31%), Gaps = 66/374 (17%) Query: 40 PARVRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPE 99 P + + H D + K + D+ +K+ A + SDI+ G++G + Sbjct: 4 PEKFEGIAIQSHEDWKNPKKTK-YDPKPFYDHDIDIKIEACGVCGSDIHCAAGHWGN-MK 61 Query: 100 LPAVGGNEGVAQVVAVGS-NVTGLKPGDWVIPA--------------------------- 131 +P V G+E V +VV +G + +GLK G V Sbjct: 62 MPLVVGHEIVGKVVKLGPKSNSGLKVGQRVGVGAQVFSCLECDRCKNDNEPYCTKFVTTY 121 Query: 132 -------NAGLGTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPG 184 G + E ++ +P +IP AA L T Y L+ PG Sbjct: 122 SQPYEDGYVSQGGYANYVRVHEHFVVPIPENIPSHLAAPLLCGGLTVYSPLVRNGCG-PG 180 Query: 185 DSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVI-TEEELR 243 V I+ A+G T + R + +GA+H I T EE Sbjct: 181 KKVGIVGLGGIG-SMGTLISKAMGAETYVISRSSRKREDAM----KMGADHYIATLEEGD 235 Query: 244 RPEMKNFFKDMPQPRLALNCVGGKS---STELLRQLARGGTMVTYGGMAKQPVVASVSLL 300 E L + C + + + + GG +V+ + + S+ Sbjct: 236 WGEKY-----FDTFDLIVVCASSLTDIDFNIMPKAMKVGGRIVSISIPEQHEM-LSLKPY 289 Query: 301 IFKDLKLRGFWLSQWKKDHSPDQFKELILTLCDLIRRGQLTAPACSQVPLQDY--QSALE 358 K + + L KEL L L+ + +P+ + A E Sbjct: 290 GLKAVSISYSALGS---------IKEL-NQLLKLVSEKDIKIWV-ETLPVGEAGVHEAFE 338 Query: 359 ASMKPFISSKQILT 372 K + + L Sbjct: 339 RMEKGDVRYRFTLV 352 >3FSR-A nrPDB Length = 352 Score = 117 bits (292), Expect = 1e-26, Method: Composition-based stats. Identities = 56/263 (21%), Positives = 92/263 (34%), Gaps = 40/263 (15%) Query: 64 ELAAVRGSDVRVKMLAAPINPSDIN-MIQGNYGFLPELPAVGGNEGVAQVVAVGSNVTGL 122 E A D V+ LA SDI+ + +G G + G+E V +VV VGS V Sbjct: 18 EKPAPGPFDAIVRPLAVAPCTSDIHTVFEGAIGERHN--MILGHEAVGEVVEVGSEVKDF 75 Query: 123 KPGDWVIP-------------------ANAGLGTWR----TEAVF--------SEEALIQ 151 KPGD V+ + L W+ + VF ++ L Sbjct: 76 KPGDRVVVPAITPDWRTSEVQRGYHQHSGGMLAGWKFSNVKDGVFGEFFHVNDADMNLAH 135 Query: 152 VPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRT 211 +P +IPL++A + T + + +Q G SV+ VG I A G Sbjct: 136 LPKEIPLEAAVMIPDMMTTGFHGA-ELADIQMGSSVVVIGI-GAVGLMGIAGAKLRGAGR 193 Query: 212 INVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFFKDMPQPRLALNCVGG-KSST 270 I V RP + K GA ++ + + + + GG ++ + Sbjct: 194 IIGVGSRPIC---VEAAKFYGATDILNYKNGHIVDQVMKLTNGKGVDRVIMAGGGSETLS 250 Query: 271 ELLRQLARGGTMVTYGGMAKQPV 293 + + + GG + Sbjct: 251 QAVSMVKPGGIISNINYHGSGDA 273 >1KEV-A nrPDB Length = 351 Score = 116 bits (290), Expect = 2e-26, Method: Composition-based stats. Identities = 58/263 (22%), Positives = 91/263 (34%), Gaps = 40/263 (15%) Query: 64 ELAAVRGSDVRVKMLAAPINPSDIN-MIQGNYGFLPELPAVGGNEGVAQVVAVGSNVTGL 122 E D V+ LA SDI+ + +G G + G+E V +VV VGS V Sbjct: 18 ERPVAGSYDAIVRPLAVSPCTSDIHTVFEGALGDRKN--MILGHEAVGEVVEVGSEVKDF 75 Query: 123 KPGDWVIP-------------------ANAGLGTWR----TEAVFSEE--------ALIQ 151 KPGD VI +N L W+ + VF E L Sbjct: 76 KPGDRVIVPCTTPDWRSLEVQAGFQQHSNGMLAGWKFSNFKDGVFGEYFHVNDADMNLAI 135 Query: 152 VPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRT 211 +P D+PL++A + T + + +Q G SV+ VG I A G Sbjct: 136 LPKDMPLENAVMITDMMTTGFHGA-ELADIQMGSSVVVIGI-GAVGLMGIAGAKLRGAGR 193 Query: 212 INVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFFKDMPQPRLALNCVGG-KSST 270 I V RP + K GA ++ + + + + GG ++ + Sbjct: 194 IIGVGSRPIC---VEAAKFYGATDILNYKNGHIVDQVMKLTNGKGVDRVIMAGGGSETLS 250 Query: 271 ELLRQLARGGTMVTYGGMAKQPV 293 + + + GG + Sbjct: 251 QAVSMVKPGGIISNINYHGSGDA 273 >2VNA-A nrPDB Length = 357 Score = 115 bits (289), Expect = 2e-26, Method: Composition-based stats. Identities = 62/347 (17%), Positives = 128/347 (36%), Gaps = 36/347 (10%) Query: 49 GHHGDP-AKVVELKNLELA-AVRGSDVRVKMLAAPINPS---DINMIQGNYGFLP-ELPA 102 G +G+P A+ ++ + L + V+V+ L ++P +N G P +L Sbjct: 14 GKNGNPVAENFRMEEVYLPDNINEGQVQVRTLYLSVDPYMRCRMNEDTGTDYITPWQLSQ 73 Query: 103 VGGNEGVAQVVAVGSNVTGLKPGDWVIPANAGLGTWRTEAVFSEEALIQVPSDIPLQSA- 161 V G+ + T L GD+V W+T+ + +L +V + Sbjct: 74 VVDGGGIGIIEESKH--TNLTKGDFVTSFYWP---WQTKVILDGNSLEKVDPQLVDGHLS 128 Query: 162 ---ATLGVNPCTAYRMLMDFEQLQPG--DSVIQNASNSGVGQAVIQIAAALGL-RTINVV 215 +G+ T+ + + + G +++ + + G QI LG R + + Sbjct: 129 YFLGAIGMPGLTSLIGIQEKGHITAGSNKTMVVSGAAGACGSVAGQIGHFLGCSRVVGIC 188 Query: 216 RDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFFKDMPQPRLALNCVGGKSSTELLRQ 275 L+ LG + I ++ E + + VGG S ++ Q Sbjct: 189 GTHEKCILLTS---ELGFDAAINYKKDNVAEQLRE-SCPAGVDVYFDNVGGNISDTVISQ 244 Query: 276 LARGGTMVTYGGMAKQ----PVVASVSLLI-----FKDLKLRGFWLSQWKKDHSPDQFKE 326 + ++ G +++ P +S I +++ F + +K D+F+ Sbjct: 245 MNENSHIILCGQISQYNKDVPYPPPLSPAIEAIQKERNITRERFLVLNYK-----DKFEP 299 Query: 327 LILTLCDLIRRGQLTAPACSQVPLQDYQSALEASMKPFISSKQILTM 373 IL L + G+L L++ +A ++ M KQI+ + Sbjct: 300 GILQLSQWFKEGKLKIKETVINGLENMGAAFQSMMTGGNIGKQIVCI 346 >3FPC-A nrPDB Length = 352 Score = 114 bits (286), Expect = 5e-26, Method: Composition-based stats. Identities = 56/250 (22%), Positives = 88/250 (35%), Gaps = 42/250 (16%) Query: 64 ELAAVRGSDVRVKMLAAPINPSDIN-MIQGNYGFLPELPAVGGNEGVAQVVAVGSNVTGL 122 E A D V+ LA SDI+ + +G G + G+E V +VV VGS V Sbjct: 18 EKPAPGPFDAIVRPLAVAPCTSDIHTVFEGAIGERHN--MILGHEAVGEVVEVGSEVKDF 75 Query: 123 KPGDWVIP-------------------ANAGLGTWR----TEAVF--------SEEALIQ 151 KPGD V+ + L W+ + VF ++ L Sbjct: 76 KPGDRVVVPAITPDWRTSEVQRGYHQHSGGMLAGWKFSNVKDGVFGEFFHVNDADMNLAH 135 Query: 152 VPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRT 211 +P +IPL++A + T + + ++ GD+V VG + A LG Sbjct: 136 LPKEIPLEAAVMIPDMMTTGFHGA-ELANIKLGDTVCVIGIGP-VGLMSVAGANHLGAGR 193 Query: 212 INVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFFKDMPQPRLALNCVGGK--SS 269 I V R D GA +I + E D + GG + Sbjct: 194 IFAVGSRKHC---CDIALEYGATDIINYKNGDIVEQILKATDGKGVDKVV-IAGGDVHTF 249 Query: 270 TELLRQLARG 279 + ++ + G Sbjct: 250 AQAVKMIKPG 259 >2CF5-A nrPDB Length = 357 Score = 114 bits (285), Expect = 7e-26, Method: Composition-based stats. Identities = 54/312 (17%), Positives = 111/312 (35%), Gaps = 48/312 (15%) Query: 49 GHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPELPAVGGNEG 108 DP+ ++ L DV ++++ I +D++ + + G P V G+E Sbjct: 13 WAARDPSGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGM-SNYPMVPGHEV 71 Query: 109 VAQVVAVGSNVTGLKPGD---------------------------WVIP-------ANAG 134 V +VV VGS+V+ GD + Sbjct: 72 VGEVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPT 131 Query: 135 LGTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNS 194 G + V ++ ++++P + ++ AA L T Y L F QPG Sbjct: 132 QGGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLGG 191 Query: 195 GVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGA-EHVITEEELRRPEMKNFFKD 253 ++IA A+G + + + L+ LGA ++VI ++ + E+ + Sbjct: 192 VG-HMGVKIAKAMGHHVTVISSSNKKRE---EALQDLGADDYVIGSDQAKMSELADSL-- 245 Query: 254 MPQPRLALNCVGG-KSSTELLRQLARGGTMVTYGGMAKQPVVASVSLLIFKDLKLRGFWL 312 ++ V + L L G ++ G + + L++ + + + G ++ Sbjct: 246 ----DYVIDTVPVHHALEPYLSLLKLDGKLILMGVINNPLQFLTPLLMLGRKV-ITGSFI 300 Query: 313 SQWKKDHSPDQF 324 K+ +F Sbjct: 301 GSMKETEEMLEF 312 >1YKF-A nrPDB Length = 352 Score = 114 bits (284), Expect = 9e-26, Method: Composition-based stats. Identities = 58/270 (21%), Positives = 95/270 (35%), Gaps = 42/270 (15%) Query: 64 ELAAVRGSDVRVKMLAAPINPSDIN-MIQGNYGFLPELPAVGGNEGVAQVVAVGSNVTGL 122 E A D V+ LA SDI+ + +G G + G+E V +VV VGS V Sbjct: 18 EKPAPGPFDAIVRPLAVAPCTSDIHTVFEGAIGERHN--MILGHEAVGEVVEVGSEVKDF 75 Query: 123 KPGDWVIP-------------------ANAGLGTWR----TEAVF--------SEEALIQ 151 KPGD V+ + L W+ + VF ++ L Sbjct: 76 KPGDRVVVPAITPDWRTSEVQRGYHQHSGGMLAGWKFSNVKDGVFGEFFHVNDADMNLAH 135 Query: 152 VPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRT 211 +P +IPL++A + T + + ++ G +V VG + A G Sbjct: 136 LPKEIPLEAAVMIPDMMTTGFHGA-ELADIELGATVAVLGIGP-VGLMAVAGAKLRGAGR 193 Query: 212 INVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFFKDMPQPRLALNCVGGKS--S 269 I V RP D K GA ++ ++ + A+ GG + Sbjct: 194 IIAVGSRPVC---VDAAKYYGATDIVNYKDGPIESQIMNLTEGKGVDAAI-IAGGNADIM 249 Query: 270 TELLRQLARGGTMVTYGGMAKQPVVASVSL 299 ++ + GGT+ + V+ L Sbjct: 250 ATAVKIVKPGGTIANVNYFGEGEVLPVPRL 279 >3WLE-A nrPDB Length = 341 Score = 113 bits (283), Expect = 1e-25, Method: Composition-based stats. Identities = 48/341 (14%), Positives = 114/341 (33%), Gaps = 60/341 (17%) Query: 62 NLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPELPAVGGNEGVAQVVAVGSNVTG 121 +L + + + +K+ A + SD+++I G V G+E V AVG +V Sbjct: 28 DLPVHKPKAGQLLLKVDAVGLCHSDLHVI--YEGLDCGDNYVMGHEIAGTVAAVGDDVIN 85 Query: 122 LKPGDWVIPANAGL----------------------------GTWRTEAVFS-EEALIQV 152 K GD V G ++ + + L ++ Sbjct: 86 YKVGDRVACVGPNGCGGCKYCRGAIDNVCKNAFGDWFGLGYDGGYQQYLLVTRPRNLSRI 145 Query: 153 PSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTI 212 P ++ AA T Y + Q+ P +++ + IQ+A A G + Sbjct: 146 PDNVSADVAAASTDAVLTPYHAI-KMAQVSPTSNILLIGAGGLG-GNAIQVAKAFGAKV- 202 Query: 213 NVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFFKDMPQPRLA--LNCVGGKSST 270 ++ D+ K LGA+ V + + + + + V +++ Sbjct: 203 ---TVLDKKKEARDQAKKLGADAVY----------ETLPESISPGSFSACFDFVSVQATF 249 Query: 271 ELLRQLARGGTMVTYGGMAKQPVVASVSLLIFKDLKLRGFWLSQWKKDHSPDQFKELILT 330 ++ ++ ++ G+ + ++ L +++++ G + + Sbjct: 250 DVCQKYVEPKGVIMPVGLGAPNLSFNLGDLALREIRILGSFWGT----------TNDLDD 299 Query: 331 LCDLIRRGQLTAPACSQVPLQDYQSALEASMKPFISSKQIL 371 + L+ G++ P L++ +E + + Sbjct: 300 VLKLVSEGKVK-PVVRSAKLKELPEYIEKLRNNAYEGRVVF 339 >3FPL-A nrPDB Length = 351 Score = 113 bits (282), Expect = 1e-25, Method: Composition-based stats. Identities = 60/270 (22%), Positives = 94/270 (34%), Gaps = 42/270 (15%) Query: 64 ELAAVRGSDVRVKMLAAPINPSDIN-MIQGNYGFLPELPAVGGNEGVAQVVAVGSNVTGL 122 E D V+ LA SDI+ + +G G + G+E V +VV VGS V Sbjct: 18 ERPVAGSYDAIVRPLAVSPCTSDIHTVFEGALGDRKN--MILGHEAVGEVVEVGSEVKDF 75 Query: 123 KPGDWVIP-------------------ANAGLGTWR----TEAVFSEE--------ALIQ 151 KPGD VI +N L W+ + VF E L Sbjct: 76 KPGDRVIVPCTTPDWRSLEVQAGFQQHSNGMLAGWKFSNFKDGVFGEYFHVNDADMNLAI 135 Query: 152 VPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRT 211 +P D+PL++A + T + + ++ G +V VG + A G Sbjct: 136 LPKDMPLENAVMITDMMTTGFHGA-ELADIELGATVAVLGIGP-VGLMAVAGAKLRGAGR 193 Query: 212 INVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFFKDMPQPRLALNCVGGKS--S 269 I V RP D K GA ++ ++ + A+ GG + Sbjct: 194 IIAVGSRPVC---VDAAKYYGATDIVNYKDGPIESQIMNLTEGKGVDAAI-IAGGNADIM 249 Query: 270 TELLRQLARGGTMVTYGGMAKQPVVASVSL 299 ++ + GGT+ + V+ L Sbjct: 250 ATAVKIVKPGGTIANVNYFGEGEVLPVPRL 279 >3B70-A nrPDB Length = 371 Score = 111 bits (278), Expect = 5e-25, Method: Composition-based stats. Identities = 57/279 (20%), Positives = 83/279 (29%), Gaps = 40/279 (14%) Query: 40 PARVRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPE 99 P + AL H + V + V V++ A INPSD M G + Sbjct: 9 PPQQTALTVNDHDE---VTVWNAAPCPMLPRDQVYVRVEAVAINPSDTKMR-GQFATPWA 64 Query: 100 LPAVGGNEGVAQVVAVGSNVTGLKPGDWVIPAN-------AGLGTWRTEAVFSEEALIQV 152 G + VVAVGS+VT ++ GD V A G + V ++ Sbjct: 65 F---LGTDYAGTVVAVGSDVTHIQVGDRVYGAQNEMCPRTPDQGAFSQYTVTRGRVWAKI 121 Query: 153 PSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDS------------VIQNASNSGVGQAV 200 P + + AA L TA + P S V+ ++ Sbjct: 122 PKGLSFEQAAALPAGISTAGLAMKLLGLPLPSPSADQPPTHSKPVYVLVYGGSTATATVT 181 Query: 201 IQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFFKDMPQPRLA 260 +Q+ G I D KS GAE V + + R A Sbjct: 182 MQMLRLSGYIPIATCSPHN-----FDLAKSRGAEEVFDYRAPNLAQTIRTYTK-NNLRYA 235 Query: 261 LNCVGGKSSTELLRQLARGGTMVTYGGMAKQPVVASVSL 299 L+C+ ST G V + Sbjct: 236 LDCITNVESTTF--------CFAAIGRAGGHYVSLNPFP 266 >2ZB3-A nrPDB Length = 353 Score = 110 bits (276), Expect = 6e-25, Method: Composition-based stats. Identities = 54/337 (16%), Positives = 115/337 (34%), Gaps = 35/337 (10%) Query: 58 VELKNLELA-AVRGSDVRVKMLAAPINPSDINMIQGNYGFLPELPAVGG----NEGVAQV 112 ++ L A+ V+V+ L ++P + + G P G+ V Sbjct: 25 FRVEEFSLPDALNEGQVQVRTLYLSVDPYMRCKMNEDTGTDYLAPWQLAQVADGGGIGVV 84 Query: 113 VAVGSNVTGLKPGDWVIPANAGLGTWRTEAVFSEEALIQVPSDIPLQSA----ATLGVNP 168 L GD+V W+T+A+ L +V + +G+ Sbjct: 85 EESKH--QKLTKGDFVTSFYWP---WQTKAILDGNGLEKVDPQLVDGHLSYFLGAIGMPG 139 Query: 169 CTAYRMLMDFEQLQPG--DSVIQNASNSGVGQAVIQIAAALGL-RTINVVRDRPDIQKLS 225 T+ + + + G +++ + + G QI LG R + + + L+ Sbjct: 140 LTSLIGVQEKGHISAGSNQTMVVSGAAGACGSLAGQIGHLLGCSRVVGICGTQEKCLFLT 199 Query: 226 DRLKSLGAEHVITEEELRRPEMKNFFKDMPQPRLALNCVGGKSSTELLRQLARGGTMVTY 285 LG + + + E + + VGG S ++ Q+ ++ Sbjct: 200 S---ELGFDAAVNYKTGNVAEQLREACPG-GVDVYFDNVGGDISNAVISQMNENSHIILC 255 Query: 286 GGMAK---------QPVVASVSLLIFKDLKLRGFWLSQWKKDHSPDQFKELILTLCDLIR 336 G +++ A ++ +++ F + +K D+F+ IL L + Sbjct: 256 GQISQYSNDVPYPPPLPPAVEAIRKERNITRERFTVLNYK-----DKFEPGILQLSQWFK 310 Query: 337 RGQLTAPACSQVPLQDYQSALEASMKPFISSKQILTM 373 G+L L++ A ++ M KQI+ + Sbjct: 311 EGKLKVKETMAKGLENMGVAFQSMMTGGNVGKQIVCI 347 >3IP1-A nrPDB Length = 404 Score = 108 bits (270), Expect = 4e-24, Method: Composition-based stats. Identities = 47/260 (18%), Positives = 85/260 (32%), Gaps = 52/260 (20%) Query: 59 ELKNLELAAV---RGSDVRVKMLAAPINPSDINMIQGN------YGFLPELPAVGGNEGV 109 E++ E+ + +++ +K+ A I SD++M Q + Y L P G+E Sbjct: 41 EVRVEEVPEPRIEKPTEIIIKVKACGICGSDVHMAQTDEEGYILYPGLTGFPVTLGHEFS 100 Query: 110 AQVVAVGSNV------TGLKPGDWVI-----------PANAGLG---------TWRTEAV 143 VV G + G+ V P G + + Sbjct: 101 GVVVEAGPEAINRRTNKRFEIGEPVCAEEMLWCGHCRPCAEGFPNHCENLNELGFNVDGA 160 Query: 144 FSEEALIQVPSDIPLQS------------AATLGVNPCTAYRML-MDFEQLQPGDSVIQN 190 F+E + L+ A +L AY + + ++PGD+V+ Sbjct: 161 FAEYVKVDAKYAWSLRELEGVYEGDRLFLAGSLVEPTSVAYNAVIVRGGGIRPGDNVVIL 220 Query: 191 ASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNF 250 +G A + I G + + + + K LGA+HVI + E Sbjct: 221 GGGP-IGLAAVAILKHAGASKVIL---SEPSEVRRNLAKELGADHVIDPTKENFVEAVLD 276 Query: 251 FKDMPQPRLALNCVGGKSST 270 + + +L L G Sbjct: 277 YTNGLGAKLFLEATGVPQLV 296 >2OUI-A nrPDB Length = 360 Score = 100 bits (248), Expect = 1e-21, Method: Composition-based stats. Identities = 62/269 (23%), Positives = 92/269 (34%), Gaps = 45/269 (16%) Query: 65 LAAVRGSDVRVKMLAAPINPSDIN-MIQGNYGFLPELPAVGGNEGVAQVVAVGSNVTGLK 123 + D V+ LA SD + + G G + + G+E V Q+V VGS V LK Sbjct: 19 IPECGPLDALVRPLALAPCTSDTHTVWAGAIGDRHD--MILGHEAVGQIVKVGSLVKRLK 76 Query: 124 PGDWV-----------------IPANAG--LGTWR----TEAVFSEE--------ALIQV 152 GD V P ++G LG W+ + VFSE L + Sbjct: 77 VGDKVIVPAITPDWGEEESQRGYPMHSGGMLGGWKFSNFKDGVFSEVFHVNEADANLALL 136 Query: 153 PSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTI 212 P DI + A L T + + ++ GD+V VG + A LG I Sbjct: 137 PRDIKPEDAVMLSDMVTTGFHGA-ELANIKLGDTVCVIGIGP-VGLMSVAGANHLGAGRI 194 Query: 213 NVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFFKDMPQPRLALNCVGGK--SST 270 V R D GA +I + E D + GG + Sbjct: 195 FAVGSRKHC---CDIALEYGATDIINYKNGDIVEQILKATDGKGVDKVV-IAGGDVHTFA 250 Query: 271 ELLRQLARG---GTMVTYGGMAKQPVVAS 296 + ++ + G G + G P+ S Sbjct: 251 QAVKMIKPGSDIGNVNYLGEGDNIPIPRS 279 >3M6I-A nrPDB Length = 363 Score = 98.3 bits (243), Expect = 5e-21, Method: Composition-based stats. Identities = 57/332 (17%), Positives = 113/332 (34%), Gaps = 51/332 (15%) Query: 67 AVRGSDVRVKMLAAPINPSDINMIQGN--YGFLPELPAVGGNEGVAQVVAVGSNVTGLKP 124 ++ +V V + + I SD++ + + E V G+E +V+AV +V +K Sbjct: 37 ELKEGEVTVAVRSTGICGSDVHFWKHGCIGPMIVECDHVLGHESAGEVIAVHPSVKSIKV 96 Query: 125 GDWV---------------------------IPANAGLGTWRTEAVFSEEALIQVPSDIP 157 GD V + G R ++ ++ Sbjct: 97 GDRVAIEPQVICNACEPCLTGRYNGCERVDFLSTPPVPGLLRRYVNHPAVWCHKI-GNMS 155 Query: 158 LQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRD 217 ++ A + P + + ++ GD V+ + +G + A A G + + Sbjct: 156 YENGA--MLEPLSVALAGLQRAGVRLGDPVLICGAGP-IGLITMLCAKAAGACPLVITDI 212 Query: 218 RPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFFK-----DMPQPRLALNCVGGKSSTEL 272 K K + V+T + R ++ K +P +AL C G +SS Sbjct: 213 DEGRLK---FAKEI-CPEVVTHKVERLSAEESAKKIVESFGGIEPAVALECTGVESSIAA 268 Query: 273 LRQLARGGTMVTYGGMAKQPVVASVSLLIFKDLKLRGFWLSQWKKDHSPDQFKELILTLC 332 + G V G+ K + +++ L+ + ++ + P + + L Sbjct: 269 AIWAVKFGGKVFVIGVGKNEIQIPFMRASVREVDLQ--FQYRY-CNTWPRAIRLVENGLV 325 Query: 333 DLIRRGQLTAPACSQVPLQDYQSALEASMKPF 364 DL R + PL+D A E + P Sbjct: 326 DLTRL------VTHRFPLEDALKAFETASDPK 351 >6DKH-A nrPDB Length = 346 Score = 91.0 bits (224), Expect = 7e-19, Method: Composition-based stats. Identities = 55/334 (16%), Positives = 105/334 (31%), Gaps = 57/334 (17%) Query: 74 RVKMLAAPINPSDINMIQ-GNYG-FLPELPAVGGNEGVAQVVAVGSNVTGLKPGDWV--- 128 V++ I SD++ Q G G F+ + P V G+E + +V+ S+ + L G V Sbjct: 34 LVQITRGGICGSDLHYYQEGKVGNFMIKAPMVLGHEVIGKVIH--SDSSELHEGQTVAIN 91 Query: 129 ----------------------------IPANAGLGTWRTEAVFSEEALIQVPSDIPLQS 160 + G + + + P+ + Sbjct: 92 PSKPCGHCKYCIEHNENQCTDMRFFGSAMYFPHVDGGFTRYKMVETSQCVPYPAKAD-EK 150 Query: 161 AATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPD 220 A +LQ G V + +G ++ LG I P Sbjct: 151 VMAFAEPLAVAIHAAHQAGELQ-GKRVFISG-VGPIGCLIVSAVKTLGAAEIVCADVSPR 208 Query: 221 IQKLSDRLKSLGAEHVITEEELRRPEMKNFFKDMPQPRLALNCVGGKSSTELLRQLARGG 280 L K +GA+ ++ + M ++ + ++ G SS ++ R Sbjct: 209 SLSLG---KEMGADVLVNPQNDD---MDHWKAEKGYFDVSFEVSGHPSSVNTCLEVTRAR 262 Query: 281 TMVTYGGMAKQPVVASVSLLIFKDLKLRGFWLSQWKKDHSPDQFKELILTLCDLIRRGQL 340 ++ GM + LI K++ LRG + +F T + G + Sbjct: 263 GVMVQVGMGGAMAEFPMMTLIGKEISLRGSF-----------RFTSEFNTAVSWLANGVI 311 Query: 341 T--APACSQVPLQDYQSALEASMKPFISSKQILT 372 ++ P D + AL + ++K L Sbjct: 312 NPLPLLSAEYPFTDLEEALRFAGDKTQAAKVQLV 345 >2VWH-A nrPDB Length = 357 Score = 72.1 bits (175), Expect = 4e-13, Method: Composition-based stats. Identities = 55/361 (15%), Positives = 108/361 (29%), Gaps = 62/361 (17%) Query: 43 VRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPELP- 101 ++A+ G+ V + + V+ L ++ +D +I G +G PE Sbjct: 1 MKAIAV-KRGEDRPV--VIEKPRPEPESGEALVRTLRVGVDGTDHEVIAGGHGGFPEGED 57 Query: 102 -AVGGNEGVAQVVAVGSNVTGLKPGDWVIPA-----NAGLGTW----------------- 138 V G+E V VV N T L+ GD V+P +G + Sbjct: 58 HLVLGHEAVGVVVD--PNDTELEEGDIVVPTVRRPPASGTNEYFERDQPDMAPDGMYFER 115 Query: 139 ---------RTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQP----GD 185 E+ L+++P L + L + Sbjct: 116 GIVGAHGYMSEFFTSPEKYLVRIPR--SQAELGFLIEPISITEKALEHAYASRSAFDWDP 173 Query: 186 SVIQNASNSGVGQAVIQIAAA--LGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELR 243 S N +G + + G + + R D ++ L A +V + R Sbjct: 174 SSAFVLGNGSLGLLTLAMLKVDDKGYENLYCLGRRDRPDPTIDIIEELDATYV----DSR 229 Query: 244 RPEMKNFFKDMPQPRLALNCVG-GKSSTELLRQLARGGTMVTYGGMAKQPVVASVSL--- 299 + +++ Q G K + + ++ LA G G + Sbjct: 230 QTPVEDVPDVYEQMDFIYEATGFPKHAIQSVQALAPNGVGALLGVPSDWAFEVDAGAFHR 289 Query: 300 -LIFKDLKLRGFWLSQWKKDHSPDQFKELILTLCDLIRRGQLTAPACSQVPLQDYQSALE 358 ++ + L G +S + E + + L PL ++++A + Sbjct: 290 EMVLHNKALVGSV-------NSHVEHFEAATVTFTKLPKWFLEDLVTGVHPLSEFEAAFD 342 Query: 359 A 359 Sbjct: 343 D 343 >4JLW-A nrPDB Length = 399 Score = 70.5 bits (171), Expect = 1e-12, Method: Composition-based stats. Identities = 53/264 (20%), Positives = 89/264 (33%), Gaps = 57/264 (21%) Query: 51 HGDPAKVVELKNLELAAVRG-------SDVRVKMLAAPINPSDINMIQGNYGFLPELPAV 103 + P KV E++N+ ++ V +++++ I SD +M++G L V Sbjct: 9 YLGPGKV-EVQNIPYPKMQDPQGRQIDHGVILRVVSTNICGSDQHMVRGRTTAPEGL--V 65 Query: 104 GGNEGVAQVVAVGSNVTGLKPGD-------------------------WVIPANAG---- 134 G+E +VV +G V +K GD V PA AG Sbjct: 66 LGHEITGEVVEIGRGVETMKIGDLVSVPFNVACGHCRTCKEQHTGVCLTVNPARAGGAYG 125 Query: 135 -------LGTWRTEAVFS--EEALIQVP-SDIPLQSAATLGV---NPCTAYRMLMDFEQL 181 +G + + L+++P + ++ L T Y + + Sbjct: 126 YVDMGGWVGGQAEYVLVPYADFNLLKLPNREAAMEKIRDLTCLSDILPTGYHGAV-TAGV 184 Query: 182 QPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEE 241 PG +V A VG A A LG + V P K G E ++ Sbjct: 185 GPGSTVYI-AGAGPVGLAAAASARLLGAAVVIVGDVNPT---RLAHAKKQGFEIADLSKD 240 Query: 242 LRRPEMKNFFKDMPQPRLALNCVG 265 E P+ A++ VG Sbjct: 241 TPLHEQIAALLGEPEVDCAVDAVG 264 >1KOL-A nrPDB Length = 398 Score = 67.5 bits (163), Expect = 1e-11, Method: Composition-based stats. Identities = 55/272 (20%), Positives = 90/272 (33%), Gaps = 60/272 (22%) Query: 43 VRALVYGHHGDPAKVVELKNLELAAVR-------GSDVRVKMLAAPINPSDINMIQGNYG 95 R +VY G VE++ ++ ++ V +K+++ I SD +M++G Sbjct: 3 NRGVVYLGSGK----VEVQKIDYPKMQDPRGKKIEHGVILKVVSTNICGSDQHMVRGRTT 58 Query: 96 FLPELPAVGGNEGVAQVVAVGSNVTGLKPGD-------------------------WVIP 130 L V G+E +V+ G +V L+ GD V P Sbjct: 59 AQVGL--VLGHEITGEVIEKGRDVENLQIGDLVSVPFNVACGRCRSCKEMHTGVCLTVNP 116 Query: 131 ANAG-----------LGTWRTEAVFS--EEALIQVPS-DIPLQSAATLGV---NPCTAYR 173 A AG G + + L+++P D ++ L T Y Sbjct: 117 ARAGGAYGYVDMGDWTGGQAEYVLVPYADFNLLKLPDRDKAMEKIRDLTCLSDILPTGYH 176 Query: 174 MLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGA 233 + + PG +V A VG A A LG + V P K+ G Sbjct: 177 GAV-TAGVGPGSTVYV-AGAGPVGLAAAASARLLGAAVVIVGDLNP---ARLAHAKAQGF 231 Query: 234 EHVITEEELRRPEMKNFFKDMPQPRLALNCVG 265 E + E P+ A++ VG Sbjct: 232 EIADLSLDTPLHEQIAALLGEPEVDCAVDAVG 263 >2DPH-A nrPDB Length = 398 Score = 63.2 bits (152), Expect = 2e-10, Method: Composition-based stats. Identities = 47/272 (17%), Positives = 86/272 (31%), Gaps = 60/272 (22%) Query: 43 VRALVYGHHGDPAKVVELKNLELAAVR------GSDVRVKMLAAPINPSDINMIQGNYGF 96 +++VY D + ++ + + V +K+++ I SD ++ +G + Sbjct: 3 NKSVVYHGTRD----LRVETVPYPKLEHNNRKLEHAVILKVVSTNICGSDQHIYRGRFIV 58 Query: 97 LPELPAVGGNEGVAQVVAVGSNVTGLKPGDWV-IPANAGLGTWRT----EAVFSEEALIQ 151 V G+E +VV GS+V + GD V +P N G R + E L+ Sbjct: 59 PKGH--VLGHEITGEVVEKGSDVELMDIGDLVSVPFNVACGRCRNCKEARSDVCENNLVN 116 Query: 152 VPSDIPL------------QSAATLGVN--------------------------PCTAYR 173 +D+ + T + Sbjct: 117 PDADLGAFGFDLKGWSGGQAEYVLVPYADYMLLKFGDKEQAMEKIKDLTLISDILPTGFH 176 Query: 174 MLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGA 233 + ++PG V A VG+ A LG + V P+ KL L G Sbjct: 177 GCVS-AGVKPGSHVYI-AGAGPVGRCAAAGARLLGAACVIVGDQNPERLKL---LSDAGF 231 Query: 234 EHVITEEELRRPEMKNFFKDMPQPRLALNCVG 265 E + + + P+ ++ VG Sbjct: 232 ETIDLRNSAPLRDQIDQILGKPEVDCGVDAVG 263 >3WID-A nrPDB Length = 369 Score = 50.1 bits (118), Expect = 1e-06, Method: Composition-based stats. Identities = 52/322 (16%), Positives = 116/322 (36%), Gaps = 69/322 (21%) Query: 41 ARVRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPEL 100 + + A+V P V+ +++ + ++K + I +D + G F Sbjct: 2 STINAIVTDA---PKGGVKYTKIDMPEPEKYEAKLKPVYIGICGTDRGEVAGALSFTYNP 58 Query: 101 P----AVGGNEGVAQVVAVGSNVTGLKPGDWVIP-------------------------- 130 V G+E + QV+ V S+ +K GD+V+P Sbjct: 59 EGENFLVLGHEALLQVLDV-SDNNYIKRGDFVVPLVRRPGKCVNCRIGRQDNCSIGDPDK 117 Query: 131 ---ANAGLGTWRTEAVFSE-EALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDS 186 GL + + ++ + + L++V +D L A L + + + S Sbjct: 118 HEAGITGLHGFMRDVIYDDIQNLVKV-NDPDLGKIAVLTEPLKNVMKA-FEVFDVVSKRS 175 Query: 187 VIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHV-ITEEELRRP 245 + QN ++ +G + + V+ + S K G + + + Sbjct: 176 IFQNDDSTFIG------------KKMVVIGSGSEAFLYSFVGKDRGFDVTMVNRHDETEN 223 Query: 246 EMK----------NFFKDMP-QPRLALNCVGGKSST-ELLRQLARGGTMVTYGGMAKQPV 293 +MK N+ KDMP + L ++ G S+ + ++++ G ++ +G K P Sbjct: 224 KMKMMDDFGVGFSNYLKDMPDKIDLLVDTSGDPSTIFKFVKKVNNNGVVILFGFNGKAPG 283 Query: 294 VA----SVSLLIFKDLKLRGFW 311 + ++ +++ + G Sbjct: 284 YPVNGEDIDYIVERNITIAGSV 305 >2CDC-A nrPDB Length = 366 Score = 49.7 bits (117), Expect = 2e-06, Method: Composition-based stats. Identities = 40/325 (12%), Positives = 91/325 (28%), Gaps = 69/325 (21%) Query: 43 VRALVYGHHGDPAKVVELKNLELAAVRG-SDVRVKMLAAPINPSDINMIQGNYGFLPELP 101 ++A++ P V++K+++ + ++++ + I +D ++ G L LP Sbjct: 1 MKAIIVKP---PNAGVQVKDVDEKKLDSYGKIKIRTIYNGICGADREIVNGKL-TLSTLP 56 Query: 102 -----AVGGNEGVAQVVAVGSNVTGLKPGDWVIPANAGLGTWRTEAVF------------ 144 V G+E + V GD V+P N + Sbjct: 57 KGKDFLVLGHEAIGVVEESYHG---FSQGDLVMPVNRRGCGICRNCLVGRPDFCETGEFG 113 Query: 145 -----------------SEEALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQP---- 183 + L+++P I + + + + ++Q Sbjct: 114 EAGIHKMDGFMREWWYDDPKYLVKIPKSIEDIGILAQPLADI--EKSIEEILEVQKRVPV 171 Query: 184 -----G----DSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAE 234 G V+ +G + GL R P + + E Sbjct: 172 WTCDDGTLNCRKVLVVG-TGPIGVLFTLLFRTYGLEVWMANRREPTEVEQTVI------E 224 Query: 235 HVITEEELRRPEMKNFFKDMPQPRLALNCVGGKS--STELLRQLARGGTMVTYGGMAKQP 292 T + + + ++ G ++ L R G + +G Sbjct: 225 ETKTNYYNSSNGYDKLKDSVGKFDVIIDATGADVNILGNVIPLLGRNGVLGLFGFSTSGS 284 Query: 293 VVAS---VSLLIFKDLKLRGFWLSQ 314 V + ++ + + G Q Sbjct: 285 VPLDYKTLQEIVHTNKTIIGLVNGQ 309 >1Q7C-A nrPDB Length = 244 Score = 46.3 bits (108), Expect = 2e-05, Method: Composition-based stats. Identities = 24/158 (15%), Positives = 52/158 (32%), Gaps = 30/158 (18%) Query: 183 PGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEEL 242 G + ++ G+G+A+ + AA G + I Q +SD L + G ++ + Sbjct: 4 EGKIALVTGASRGIGRAIAETLAARGAKVIGTATSENGAQAISDYLGANGKGLMLNVTDP 63 Query: 243 RRPE--MKNFFKDMPQPRLALNCVG-----------GKSSTELL---------------R 274 E ++ + + + +N G + +++ R Sbjct: 64 ASIESVLEKIRAEFGEVDILVNNAGITRDNLLMRMKDEEWNDIIETNLSSVFRLSKAVMR 123 Query: 275 QL--ARGGTMVTYGGMAKQPVVASVSLLIFKDLKLRGF 310 + R G ++T G + + L GF Sbjct: 124 AMMKKRHGRIITIGSVVGTMGNGGQANFAAAKAGLIGF 161 >3RSH-A nrPDB Length = 251 Score = 45.1 bits (105), Expect = 4e-05, Method: Composition-based stats. Identities = 18/99 (18%), Positives = 36/99 (36%), Gaps = 3/99 (3%) Query: 183 PGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITE--E 240 G + ++ G+G+A+ ++ A G + I Q +SD L G + Sbjct: 11 EGKVALVTGASRGIGKAIAELLAERGAKVIGTATSESGAQAISDYLGDNGKGMALNVTNP 70 Query: 241 ELRRPEMKNFFKDMPQPRLALNCVGGKSSTELLRQLARG 279 E +K + + +N G + LL ++ Sbjct: 71 ESIEAVLKAITDEFGGVDILVNNAGI-TRDNLLMRMKEE 108 >3VZS-A nrPDB Length = 257 Score = 44.4 bits (103), Expect = 8e-05, Method: Composition-based stats. Identities = 15/83 (18%), Positives = 33/83 (39%), Gaps = 6/83 (7%) Query: 189 QNASNSGVGQAVIQIAAALGLRTINVVR-DRPDIQKLSDRLKSLGAEHVITEE-----EL 242 G+G A+ Q A G R + + P +K ++ K+LG + + +E + Sbjct: 19 VTGGMGGIGTAICQRLAKDGFRVVAGCGPNSPRREKWLEQQKALGFDFIASEGNVADWDS 78 Query: 243 RRPEMKNFFKDMPQPRLALNCVG 265 + ++ + + +N G Sbjct: 79 TKTAFDKVKSEVGEVDVLINNAG 101 >3DWF-A nrPDB Length = 276 Score = 43.6 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 14/52 (26%), Positives = 24/52 (46%), Gaps = 2/52 (3%) Query: 183 PGDSVIQNASNSGVG-QAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGA 233 G VI ++ G+G + +A +G + R + +QK+ R LGA Sbjct: 10 QGKKVIVTGASKGIGREIAYHLAK-MGAHVVVTARSKEALQKVVARCLELGA 60 >3EZL-A nrPDB Length = 256 Score = 41.7 bits (96), Expect = 5e-04, Method: Composition-based stats. Identities = 13/83 (15%), Positives = 29/83 (34%), Gaps = 6/83 (7%) Query: 189 QNASNSGVGQAVIQIAAALGLRTINVVR-DRPDIQKLSDRLKSLGAEHVITEE-----EL 242 G+G ++ Q G R + + P K + K+LG + +E + Sbjct: 18 VTGGMGGIGTSICQRLHKDGFRVVAGCGPNSPRRVKWLEDQKALGFDFYASEGNVGDWDS 77 Query: 243 RRPEMKNFFKDMPQPRLALNCVG 265 + ++ + + +N G Sbjct: 78 TKQAFDKVKAEVGEIDVLVNNAG 100 >2UVD-A nrPDB Length = 246 Score = 41.7 bits (96), Expect = 6e-04, Method: Composition-based stats. Identities = 18/102 (17%), Positives = 38/102 (37%), Gaps = 5/102 (4%) Query: 183 PGDSVIQNASNSGVGQA-VIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEE 241 G + ++ G+G+A I +A +N + ++ D +K LG++ + + Sbjct: 3 KGKVALVTGASRGIGRAIAIDLAKQGANVVVNYAGNEQKANEVVDEIKKLGSDAIAVRAD 62 Query: 242 LRRPE----MKNFFKDMPQPRLALNCVGGKSSTELLRQLARG 279 + E M D+ L G + LL ++ Sbjct: 63 VANAEDVTNMVKQTVDVFGQVDILVNNAGVTKDNLLMRMKEE 104 >3F9I-A nrPDB Length = 249 Score = 41.3 bits (95), Expect = 7e-04, Method: Composition-based stats. Identities = 19/94 (20%), Positives = 37/94 (39%), Gaps = 3/94 (3%) Query: 184 GDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELR 243 G + + ++SG+G A+ ++ LG + I + ++ L + LK + I L Sbjct: 14 GKTSLITGASSGIGSAIARLLHKLGSKVIISGSNEEKLKSLGNALKD---NYTIEVCNLA 70 Query: 244 RPEMKNFFKDMPQPRLALNCVGGKSSTELLRQLA 277 E + L C G +S L ++ Sbjct: 71 NKEECSNLISKTSNLDILVCNAGITSDTLAIRMK 104 >5PGZ-A nrPDB Length = 276 Score = 40.9 bits (94), Expect = 8e-04, Method: Composition-based stats. Identities = 13/51 (25%), Positives = 23/51 (45%) Query: 183 PGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGA 233 G VI ++ G+G+ + + +G + R +QK+ R LGA Sbjct: 17 QGKKVIVTGASKGIGREMAYHLSKMGAHVVLTARSEEGLQKVVSRCLELGA 67 >4BO1-A nrPDB Length = 269 Score = 40.5 bits (93), Expect = 0.001, Method: Composition-based stats. Identities = 20/100 (20%), Positives = 43/100 (43%), Gaps = 6/100 (6%) Query: 183 PGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHV-----I 237 G + ++ G+GQA+ LG I +K+++ LK+ G E + Sbjct: 26 QGKVALVTGASRGIGQAIALELGRLGAVVIGTATSASGAEKIAETLKANGVEGAGLVLDV 85 Query: 238 TEEELRRPEMKNFFKDMPQPRLALNCVGGKSSTELLRQLA 277 + +E +++ + + QP + +N G + LL ++ Sbjct: 86 SSDESVAATLEHIQQHLGQPLIVVNNAGI-TRDNLLVRMK 124 >3EMK-A nrPDB Length = 246 Score = 39.7 bits (91), Expect = 0.002, Method: Composition-based stats. Identities = 17/87 (19%), Positives = 33/87 (37%), Gaps = 8/87 (9%) Query: 184 GDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVI-----T 238 G + + G+G+A IA AL + V +KL + LG + + Sbjct: 7 GRKALVTGATGGLGEA---IARALHAQGAIVGLHGTREEKLKELAAELGERIFVFPANLS 63 Query: 239 EEELRRPEMKNFFKDMPQPRLALNCVG 265 + E + + ++M + +N G Sbjct: 64 DREAVKALGQKAEEEMGGVDILVNNAG 90 >5CDY-A nrPDB Length = 244 Score = 39.3 bits (90), Expect = 0.002, Method: Composition-based stats. Identities = 18/158 (11%), Positives = 43/158 (27%), Gaps = 30/158 (18%) Query: 183 PGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEEL 242 G + ++ G+G+A+ ++ G I + +S L G ++ + Sbjct: 4 EGKIALVTGASRGIGRAIAELLVERGACVIGTATSEKGAEAISAYLGENGKGLMLNVVDP 63 Query: 243 RRPEMKNFF--KDMPQPRLALNCVG-----------GKSSTELLR--------------- 274 + + + + +N G +++ Sbjct: 64 TSIDTVLATIRAEFGEVDILVNNAGITRDNLLMRMKDDEWQDIIDTNLTSVFRLSKAVMR 123 Query: 275 --QLARGGTMVTYGGMAKQPVVASVSLLIFKDLKLRGF 310 R G ++T G + A + GF Sbjct: 124 AMMKKRFGRIITIGSVVGTMGNAGQVNYAAAKAGVIGF 161 >3D3W-A nrPDB Length = 244 Score = 39.0 bits (89), Expect = 0.003, Method: Composition-based stats. Identities = 15/91 (16%), Positives = 30/91 (32%), Gaps = 3/91 (3%) Query: 183 PGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEEL 242 G V+ + G+G+ +Q A G R + V R + D+ L ++ + + Sbjct: 6 AGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSL---VRECPGIEPVCVDLG 62 Query: 243 RRPEMKNFFKDMPQPRLALNCVGGKSSTELL 273 + + L +N L Sbjct: 63 DWEATERALGSVGPVDLLVNNAAVALLQPFL 93 >5JJC-A nrPDB Length = 342 Score = 39.0 bits (89), Expect = 0.004, Method: Composition-based stats. Identities = 20/58 (34%), Positives = 28/58 (48%), Gaps = 2/58 (3%) Query: 177 DFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAE 234 L+PG VI + G + +A ALG RT V+ + Q+ D L+ LGAE Sbjct: 55 KRGLLRPGG-VIVEGTAGNTGIGLTMVAKALGYRTAIVIPETAS-QEKKDALRLLGAE 110 >4M8S-A nrPDB Length = 248 Score = 39.0 bits (89), Expect = 0.004, Method: Composition-based stats. Identities = 21/99 (21%), Positives = 38/99 (38%), Gaps = 4/99 (4%) Query: 184 GDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAE-HVITEEEL 242 G + ++ G+G A+ AA G + I +S+RL G E V+ E Sbjct: 8 GKIALVTGASRGIGAAIADTLAAAGAKVIGTATSESGAAAISERLAQWGGEGRVLNSAEP 67 Query: 243 RRPE--MKNFFKDMPQPRLALNCVGGKSSTELLRQLARG 279 E + + K + + +N G + LL ++ Sbjct: 68 ETVENLIADIEKTFGKLDILVNNAGI-TRDNLLMRMKEE 105 >1AHH-A nrPDB Length = 255 Score = 38.2 bits (87), Expect = 0.006, Method: Composition-based stats. Identities = 17/89 (19%), Positives = 32/89 (35%), Gaps = 7/89 (7%) Query: 184 GDSVIQNASNSGVGQ-AVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHV-----I 237 G I + +G+G+ I A A G + + + D ++ LG + I Sbjct: 11 GKCAIITGAGAGIGKEIAITFATA-GASVVVSDINADAANHVVDEIQQLGGQAFACRCDI 69 Query: 238 TEEELRRPEMKNFFKDMPQPRLALNCVGG 266 T E+ + + + +N GG Sbjct: 70 TSEQELSALADFAISKLGKVDILVNNAGG 98 >2B4Q-A nrPDB Length = 276 Score = 38.2 bits (87), Expect = 0.006, Method: Composition-based stats. Identities = 18/101 (17%), Positives = 31/101 (30%), Gaps = 3/101 (2%) Query: 183 PGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEEL 242 G + + G+GQ + Q G R RD + RL + G I + Sbjct: 28 AGRIALVTGGSRGIGQMIAQGLLEAGARVFICARDAEACADTATRLSAYGDCQAIPADLS 87 Query: 243 RRPEMKNFFKDMPQPRLALNCV---GGKSSTELLRQLARGG 280 + + + + L+ + G S L G Sbjct: 88 SEAGARRLAQALGELSARLDILVNNAGTSWGAALESYPVSG 128 >3OSU-A nrPDB Length = 246 Score = 38.2 bits (87), Expect = 0.006, Method: Composition-based stats. Identities = 13/100 (13%), Positives = 37/100 (37%), Gaps = 7/100 (7%) Query: 185 DSVIQNASNSGVG-QAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHV-----IT 238 S + ++ G+G +Q+A +N + + + + +K+ G + + Sbjct: 5 KSALVTGASRGIGRSIALQLAEEGYNVAVNYAGSKEKAEAVVEEIKAKGVDSFAIQANVA 64 Query: 239 EEELRRPEMKNFFKDMPQPRLALNCVGGKSSTELLRQLAR 278 + + + +K + +N G + LL ++ Sbjct: 65 DADEVKAMIKEVVSQFGSLDVLVNNAGI-TRDNLLMRMKE 103 >1GEE-A nrPDB Length = 261 Score = 38.2 bits (87), Expect = 0.006, Method: Composition-based stats. Identities = 14/89 (15%), Positives = 36/89 (40%), Gaps = 6/89 (6%) Query: 183 PGDSVIQNASNSGVG-QAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEE 241 G V+ S++G+G I+ A +N + + + +K +G E + + + Sbjct: 6 EGKVVVITGSSTGLGKSMAIRFATEKAKVVVNYRSKEDEANSVLEEIKKVGGEAIAVKGD 65 Query: 242 LRRPE-----MKNFFKDMPQPRLALNCVG 265 + +++ K+ + + +N G Sbjct: 66 VTVESDVINLVQSAIKEFGKLDVMINNAG 94 >3GRP-A nrPDB Length = 266 Score = 37.8 bits (86), Expect = 0.007, Method: Composition-based stats. Identities = 16/87 (18%), Positives = 33/87 (37%), Gaps = 8/87 (9%) Query: 184 GDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELR 243 G + + G+G+A+ + A G + + R D KL + LG + + L Sbjct: 27 GRKALVTGATGGIGEAIARCFHAQGA-IVGLHGTRED--KLKEIAADLGKDVFVFSANLS 83 Query: 244 -----RPEMKNFFKDMPQPRLALNCVG 265 + + ++M + +N G Sbjct: 84 DRKSIKQLAEVAEREMEGIDILVNNAG 110 >3RKU-A nrPDB Length = 287 Score = 37.4 bits (85), Expect = 0.011, Method: Composition-based stats. Identities = 19/114 (16%), Positives = 47/114 (41%), Gaps = 10/114 (8%) Query: 176 MDFEQLQPGDSVIQNASNSGVGQA-VIQIAAALG--LRTINVVRDRPDIQKLSDR----- 227 + +V+ +++G+G+A ++ A ++ I R +++L Sbjct: 25 RKAAERLAKKTVLITGASAGIGKATALEYLEASNGDMKLILAARRLEKLEELKKTIDQEF 84 Query: 228 --LKSLGAEHVITEEELRRPEMKNFFKDMPQPRLALNCVGGKSSTELLRQLARG 279 K A+ IT+ E +P ++N ++ + +N G ++ + Q+A Sbjct: 85 PNAKVHVAQLDITQAEKIKPFIENLPQEFKDIDILVNNAGKALGSDRVGQIATE 138 >5ILO-A nrPDB Length = 271 Score = 37.4 bits (85), Expect = 0.011, Method: Composition-based stats. Identities = 11/91 (12%), Positives = 30/91 (32%), Gaps = 12/91 (13%) Query: 184 GDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHV------- 236 G + + G+G V + A G + ++ + +++ + +K A Sbjct: 15 GKNAVVTGGAGGIGLQVSKQLLAAGAAKVAIIDLQDNLE---EFVKLRAAHPTQSVMIIK 71 Query: 237 --ITEEELRRPEMKNFFKDMPQPRLALNCVG 265 + ++ + K + +N G Sbjct: 72 MDVANKKGVEATYEEIAKTFGNIDIVVNVAG 102 >3LYL-A nrPDB Length = 247 Score = 36.6 bits (83), Expect = 0.017, Method: Composition-based stats. Identities = 14/80 (17%), Positives = 35/80 (43%), Gaps = 5/80 (6%) Query: 188 IQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEH---VITEEELRR 244 + ++ G+G V A+ G + + +K + +K G + V+ ++ Sbjct: 9 LVTGASRGIGFEVAHALASKGATVVGTATSQASAEKFENSMKEKGFKARGLVLNISDIE- 67 Query: 245 PEMKNFFKDMPQPRLALNCV 264 ++NFF ++ LA++ + Sbjct: 68 -SIQNFFAEIKAENLAIDIL 86 >2C07-A nrPDB Length = 285 Score = 36.3 bits (82), Expect = 0.022, Method: Composition-based stats. Identities = 15/99 (15%), Positives = 34/99 (34%), Gaps = 7/99 (7%) Query: 183 PGDSVIQNASNSGVG-QAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHV----- 236 + + G+G + +A ++ I + R + + D +KS G E Sbjct: 43 ENKVALVTGAGRGIGREIAKMLAKSV-SHVICISRTQKSCDSVVDEIKSFGYESSGYAGD 101 Query: 237 ITEEELRRPEMKNFFKDMPQPRLALNCVGGKSSTELLRQ 275 ++++E + + + +N G LR Sbjct: 102 VSKKEEISEVINKILTEHKNVDILVNNAGITRDNLFLRM 140 >3IYF-A nrPDB Length = 521 Score = 35.9 bits (81), Expect = 0.031, Method: Composition-based stats. Identities = 36/242 (14%), Positives = 70/242 (28%), Gaps = 32/242 (13%) Query: 72 DVRVKMLAAPINPSDINMIQGNYGFLPELPAVGGNEGVAQVVAVGSNVTGLKPGDWVIPA 131 ++ K+ I +G +L + A V G L + A Sbjct: 148 EILTKIAMTSITG------KGAEKAKEKLAEIIVEAVSAVVDDEGKVDKDLIKIEKKSGA 201 Query: 132 NAGLGTWRTEAVFS-EEALIQVPSDIPLQSAATLGVNPC-TAYRMLMD-FEQLQP-GDSV 187 + + E Q+P + A L TA ML D +++ G +V Sbjct: 202 SIDDTELIKGVLVDKERVSAQMPKKVTDAKIALLNCAIEETASEMLKDMVAEIKASGANV 261 Query: 188 I------------------QNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRL- 228 + A+ + ++A A G I ++D L Sbjct: 262 LFCQKGIDDLAQHYLAKEGIVAARRVKKSDMEKLAKATGANVITNIKDLSAQDLGDAGLV 321 Query: 229 --KSLGAEHVITEEELRRPEMKNFFKDMPQPRLALNCV-GGKSSTELLRQLARGGTMVTY 285 + + + +I EE + P+ + + ++ G +V+ Sbjct: 322 EERKISGDSMIFVEECKHPKAVTMLIRGTTEHVIEEVARAVDDAVGVVGCTIEDGRIVSG 381 Query: 286 GG 287 GG Sbjct: 382 GG 383 >4AEC-A nrPDB Length = 430 Score = 35.5 bits (80), Expect = 0.034, Method: Composition-based stats. Identities = 27/121 (22%), Positives = 47/121 (38%), Gaps = 20/121 (16%) Query: 171 AYRMLMDFEQ---LQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDR 227 Y M+ D EQ + PG SV+ ++ G + IAA+ G R I + +++ Sbjct: 158 GYSMVTDAEQKGFISPGKSVLVEPTSGNTGIGLAFIAASRGYRLILTMPASMSMERRV-L 216 Query: 228 LKSLGAEHVITE----------------EELRRPEMKNFFKDMPQPRLALNCVGGKSSTE 271 LK+ GAE V+T+ + M F + P++ G + + Sbjct: 217 LKAFGAELVLTDPAKGMTGAVQKAEEILKNTPDAYMLQQFDNPANPKIHYETTGPEIWDD 276 Query: 272 L 272 Sbjct: 277 T 277 >4F86-A nrPDB Length = 320 Score = 35.5 bits (80), Expect = 0.041, Method: Composition-based stats. Identities = 22/122 (18%), Positives = 39/122 (31%), Gaps = 9/122 (7%) Query: 171 AYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKS 230 A +L + PGD+ + +A G V+ G + V + + R + Sbjct: 113 AEFLLDHLGPVGPGDT-LVDAGCGRGGSMVMAHQR-FGCKVEGVTLSAAQAEFGNRRARE 170 Query: 231 LGAEH-----VITEEELRRPEMKNFFKDMPQPRLALNCVGGKSSTELLRQLARGGTMVTY 285 LG + V + + + + ++ E R L GG VT Sbjct: 171 LGIDDHVRSRVCNMLDTPFEKGTVAASWNNESSMYVDL--HDVFAEHSRFLRVGGRYVTV 228 Query: 286 GG 287 G Sbjct: 229 TG 230 >1V9L-A nrPDB Length = 421 Score = 34.7 bits (78), Expect = 0.059, Method: Composition-based stats. Identities = 30/208 (14%), Positives = 57/208 (27%), Gaps = 48/208 (23%) Query: 124 PGDWVIPANAGLGTWRTEAV--FSEEALIQ----------VPSDI---PLQSAATLGVNP 168 GD V +GT E + I+ P ++ P++ AT Sbjct: 135 IGDVVDIPAPDVGTNAQIMAWMVDEYSKIKGYNVPGVFTSKPPELWGNPVREYATGFGVA 194 Query: 169 CTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRP--------- 219 M G +V VG+ +G + I V Sbjct: 195 VATREMAKKLWGGIEGKTVAIQG-MGNVGRWTAYWLEKMGAKVIAVSDINGVAYRKEGLN 253 Query: 220 -------------------DIQKLSDRLKSLGAEHVITEEELRRPEMKNFFK----DMPQ 256 + ++ +K+ A + + ++N + + + Sbjct: 254 VELIQKNKGLTGPALVELFTTKDNAEFVKNPDAIFKLDVDIFVPAAIENVIRGDNAGLVK 313 Query: 257 PRLALNCVGGKSSTELLRQLARGGTMVT 284 RL + G ++ E R L G +V Sbjct: 314 ARLVVEGANGPTTPEAERILYERGVVVV 341 >3T4P-A nrPDB Length = 334 Score = 34.7 bits (78), Expect = 0.059, Method: Composition-based stats. Identities = 15/72 (20%), Positives = 32/72 (44%), Gaps = 1/72 (1%) Query: 168 PCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDR 227 Y +L PG S++ +S+ G ++ + A G + I + + +++ Sbjct: 55 GFAIYDKAEKEGKLIPGKSIVVESSSGNTGVSLAHLGAIRGYKVIITMPESMSLERRC-L 113 Query: 228 LKSLGAEHVITE 239 L+ GAE ++T Sbjct: 114 LRIFGAEVILTP 125 >3WOH-A nrPDB Length = 251 Score = 34.7 bits (78), Expect = 0.061, Method: Composition-based stats. Identities = 14/88 (15%), Positives = 30/88 (34%), Gaps = 6/88 (6%) Query: 184 GDSVIQNASNSGVG-QAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEEL 242 G + + G+G +++A I V D ++ ++ LG ++ Sbjct: 11 GKVALVTGGSRGLGRAMALRLARDGAAVAIVYVSDDSSAKETQGEIERLGGTARSYRCDV 70 Query: 243 RRPE-----MKNFFKDMPQPRLALNCVG 265 E +K D+ + +N G Sbjct: 71 SDAEQVTRCVKAVTADLGPVDILVNNAG 98 >5IJZ-A nrPDB Length = 447 Score = 34.7 bits (78), Expect = 0.062, Method: Composition-based stats. Identities = 27/157 (17%), Positives = 49/157 (31%), Gaps = 22/157 (14%) Query: 170 TAYRMLMDFEQL--QPGDSV----IQNASNSGVGQAVIQIAAALGLRTINVVRDRP---- 219 T Y + ++ G+S+ I + + V I+ A LG I Sbjct: 212 TGYGCVYFVSEMIKAKGESISGQKIIVSGSGNVATYAIEKAQELGATVIGFSDSSGWVHT 271 Query: 220 ----DIQKLSDRLKSLGAEHVITEEELRRPEMKNFFKDMP----QPRLALNCVGGKSST- 270 D+ KL + + A + +E+ D + +AL C Sbjct: 272 PNGVDVAKLREIKEVRRARVSVYADEVEGATYH---TDGSIWDLKCDIALPCATQNELNG 328 Query: 271 ELLRQLARGGTMVTYGGMAKQPVVASVSLLIFKDLKL 307 E + LA G G +V + +D++ Sbjct: 329 ENAKTLADNGCRFVAEGANMPSTPEAVEVFRERDIRF 365 >1XDW-A nrPDB Length = 331 Score = 34.7 bits (78), Expect = 0.069, Method: Composition-based stats. Identities = 21/113 (18%), Positives = 41/113 (36%), Gaps = 15/113 (13%) Query: 186 SVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITE------ 239 +V +G+ QI +G I D +I+ + D + + V+ + Sbjct: 148 TVGVVG-LGRIGRVAAQIFHGMGATVIG--EDVFEIKGIEDYCTQVSLDEVLEKSDIITI 204 Query: 240 -----EELRRPEMKNFFKDMPQPRLALNCVGGKSST-ELLRQLARGGTMVTYG 286 +E ++F K M + +NC G+ E + + G + YG Sbjct: 205 HAPYIKENGAVVTRDFLKKMKDGAILVNCARGQLVDTEAVIEAVESGKLGGYG 257 >3WTC-A nrPDB Length = 262 Score = 34.7 bits (78), Expect = 0.074, Method: Composition-based stats. Identities = 15/88 (17%), Positives = 36/88 (40%), Gaps = 7/88 (7%) Query: 184 GDSVIQNASNSGVGQA-VIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHV-----I 237 G + G+G+A +++A G I + + + + + +++LG V I Sbjct: 8 GKIAAVTGAAQGIGKAIALRLAK-DGADVILLDVKQDTLAETAKEVEALGRRAVALTADI 66 Query: 238 TEEELRRPEMKNFFKDMPQPRLALNCVG 265 + + R + + K + + +N G Sbjct: 67 SNRDQFRSTLADAAKTLGGLDIMVNNAG 94 >1HXH-A nrPDB Length = 253 Score = 34.3 bits (77), Expect = 0.083, Method: Composition-based stats. Identities = 16/85 (18%), Positives = 32/85 (37%), Gaps = 2/85 (2%) Query: 183 PGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRL--KSLGAEHVITEE 240 G + SGVG V+++ G + + Q+L+ L +S+ H ++ E Sbjct: 5 QGKVALVTGGASGVGLEVVKLLLGEGAKVAFSDINEAAGQQLAAELGERSMFVRHDVSSE 64 Query: 241 ELRRPEMKNFFKDMPQPRLALNCVG 265 M + + + +N G Sbjct: 65 ADWTLVMAAVQRRLGTLNVLVNNAG 89 >1AE1-A nrPDB Length = 273 Score = 34.3 bits (77), Expect = 0.094, Method: Composition-based stats. Identities = 10/50 (20%), Positives = 23/50 (46%) Query: 183 PGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLG 232 G + + + G+G A+++ A LG R R+ ++ + + + G Sbjct: 20 KGTTALVTGGSKGIGYAIVEELAGLGARVYTCSRNEKELDECLEIWREKG 69 >2HQ1-A nrPDB Length = 247 Score = 34.0 bits (76), Expect = 0.098, Method: Composition-based stats. Identities = 16/89 (17%), Positives = 36/89 (40%), Gaps = 6/89 (6%) Query: 183 PGDSVIQNASNSGVGQAVIQIAAALGLRTI-NVVRDRPDIQKLSDRLKSLGAEHVITEEE 241 G + I S+ G+G+A+ +G + N + ++ K+ G V+ + + Sbjct: 4 KGKTAIVTGSSRGLGKAIAWKLGNMGANIVLNGSPASTSLDATAEEFKAAGINVVVAKGD 63 Query: 242 LRRPE-----MKNFFKDMPQPRLALNCVG 265 ++ PE +K + + +N G Sbjct: 64 VKNPEDVENMVKTAMDAFGRIDILVNNAG 92 >5TQV-A nrPDB Length = 233 Score = 34.0 bits (76), Expect = 0.10, Method: Composition-based stats. Identities = 17/83 (20%), Positives = 33/83 (39%), Gaps = 7/83 (8%) Query: 185 DSVIQNASNSGVG-QAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAE-HVITEEEL 242 +V+ ++ G+G + V Q G I RD + L++LGA H + + Sbjct: 10 KTVLIVGASRGLGREFVRQYQR-DGWNVIATARDDASLAA----LRALGAHAHALDITQP 64 Query: 243 RRPEMKNFFKDMPQPRLALNCVG 265 + + D + +A+ G Sbjct: 65 EQIAALGWKLDGERLDVAVVVSG 87 >2PNF-A nrPDB Length = 248 Score = 34.0 bits (76), Expect = 0.11, Method: Composition-based stats. Identities = 28/207 (13%), Positives = 58/207 (28%), Gaps = 39/207 (18%) Query: 183 PGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDR------LKSLGAEHV 236 G + S G+G+A+ + A+ G I + +++ +K+ G E Sbjct: 6 QGKVSLVTGSTRGIGRAIAEKLASAGSTVIITGTSGERAKAVAEEIANKYGVKAHGVEMN 65 Query: 237 ITEEELRRPEMKNFFKDMPQPRLALNCVGGK--------------------------SST 270 + EE + + + + +N G + Sbjct: 66 LLSEESINKAFEEIYNLVDGIDILVNNAGITRDKLFLRMSLLDWEEVLKVNLTGTFLVTQ 125 Query: 271 ELLRQL--ARGGTMVTYGGMAKQPVVASVSLLIFKDLKLRGFWLSQWKKDHSPDQFKELI 328 LR++ R G +V + L GF S K+ + + Sbjct: 126 NSLRKMIKQRWGRIVNISSVVGFTGNVGQVNYSTTKAGLIGFTKSLAKELAPRNVLVNAV 185 Query: 329 LTLC-----DLIRRGQLTAPACSQVPL 350 + ++ Q+PL Sbjct: 186 APGFIETDMTAVLSEEIKQKYKEQIPL 212 >4IS3-A nrPDB Length = 268 Score = 33.6 bits (75), Expect = 0.13, Method: Composition-based stats. Identities = 14/93 (15%), Positives = 28/93 (30%), Gaps = 7/93 (7%) Query: 180 QLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKS-------LG 232 L I G+G A +I G + + ++ +LK LG Sbjct: 21 NLVQDKVTIITGGTRGIGFAAAKIFIDNGAKVSIFGETQEEVDTALAQLKELYPEEEVLG 80 Query: 233 AEHVITEEELRRPEMKNFFKDMPQPRLALNCVG 265 +T + + + + + +N G Sbjct: 81 FAPDLTSRDAVMAAVGQVAQKYGRLDVMINNAG 113 >1CYD-A nrPDB Length = 244 Score = 33.6 bits (75), Expect = 0.15, Method: Composition-based stats. Identities = 12/82 (14%), Positives = 26/82 (31%), Gaps = 3/82 (3%) Query: 184 GDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELR 243 G + + G+G+ ++ A G + + V R D+ L K + + Sbjct: 7 GLRALVTGAGKGIGRDTVKALHASGAKVVAVTRTNSDLVSL---AKECPGIEPVCVDLGD 63 Query: 244 RPEMKNFFKDMPQPRLALNCVG 265 + + L +N Sbjct: 64 WDATEKALGGIGPVDLLVNNAA 85 >5T5Q-A nrPDB Length = 247 Score = 33.6 bits (75), Expect = 0.17, Method: Composition-based stats. Identities = 10/48 (20%), Positives = 22/48 (45%) Query: 183 PGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKS 230 +++ +N G+G+A+ ++ A G + DR + + L S Sbjct: 8 ENRTLVLTGANGGIGRAIAELFHASGANLVLTDLDREGLDAFAASLGS 55 >4FHN-X nrPDB Length = 450 Score = 33.2 bits (74), Expect = 0.18, Method: Composition-based stats. Identities = 16/71 (22%), Positives = 21/71 (29%), Gaps = 2/71 (2%) Query: 160 SAATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRP 219 A G+ T ML G V + + V Q I+ A G R I Sbjct: 212 EATGYGLVYFT-EAMLKRHGMGFEGMRVSVSG-SGNVAQYAIEKAMEFGARVITASDSSG 269 Query: 220 DIQKLSDRLKS 230 + S K Sbjct: 270 TVVDESGFTKE 280 >5YSS-A nrPDB Length = 256 Score = 33.2 bits (74), Expect = 0.20, Method: Composition-based stats. Identities = 15/85 (17%), Positives = 30/85 (35%), Gaps = 3/85 (3%) Query: 184 GDSVIQNASNSGVGQAVIQIAAALGLRTI--NVVRDRPDIQKLSDRLKSLGAEHVITEEE 241 G + + S SG+G + Q+ A G I ++ K+ G +E Sbjct: 5 GKTALVTGSTSGIGLGIAQVLAQAGATLILNGFGDVDAAKDAVAQYGKTPGYHGADLSDE 64 Query: 242 LRRPE-MKNFFKDMPQPRLALNCVG 265 + + M+ + + +N G Sbjct: 65 AQIADMMRYAESEFGGVDILINNAG 89 >4R1U-A nrPDB Length = 349 Score = 32.8 bits (73), Expect = 0.26, Method: Composition-based stats. Identities = 14/91 (15%), Positives = 33/91 (36%), Gaps = 4/91 (4%) Query: 173 RMLMDFEQLQPGD-SVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSL 231 L + + GD +V + + ++++ G VR+ D + LK L Sbjct: 15 SCLDNTSSVSGGDQTVCVTGAGGFIASWLVKLLLERGYTVRGTVRNPEDPKNGH--LKEL 72 Query: 232 -GAEHVITEEELRRPEMKNFFKDMPQPRLAL 261 GA +T ++ ++++ + Sbjct: 73 EGARERLTLHKVDLLDLQSIQSVVHGCHGVF 103 >3FTP-A nrPDB Length = 270 Score = 32.8 bits (73), Expect = 0.27, Method: Composition-based stats. Identities = 14/96 (14%), Positives = 34/96 (35%), Gaps = 8/96 (8%) Query: 188 IQNASNSGVGQA-VIQIAAALGLRTINVVRDRPDIQKLSDRLKSL-----GAEHVITEEE 241 I ++ G+G+A +++A G I + + K GA + + Sbjct: 32 IVTGASRGIGRAIALELAR-RGAMVIGTATTEAGAEGIGAAFKQAGLEGRGAVLNVNDAT 90 Query: 242 LRRPEMKNFFKDMPQPRLALNCVGGKSSTELLRQLA 277 +++ K+ + +N G +L ++ Sbjct: 91 AVDALVESTLKEFGALNVLVNNAGITQ-DQLAMRMK 125 >5OJG-A nrPDB Length = 260 Score = 32.8 bits (73), Expect = 0.28, Method: Composition-based stats. Identities = 15/89 (16%), Positives = 35/89 (39%), Gaps = 6/89 (6%) Query: 183 PGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHV------ 236 G I A+ G+G A+ + G + R++ ++ + + LK+ G V Sbjct: 9 EGKVAIVTAATKGIGLAIAERLLDEGASVVIGSRNQKNVDEAIEYLKNKGLTKVAGIAGH 68 Query: 237 ITEEELRRPEMKNFFKDMPQPRLALNCVG 265 I + ++ + + + + +N G Sbjct: 69 IASTDDQKKLVDFTLQKFGKINILVNNHG 97 >2YFH-A nrPDB Length = 448 Score = 32.4 bits (72), Expect = 0.30, Method: Composition-based stats. Identities = 16/71 (22%), Positives = 21/71 (29%), Gaps = 2/71 (2%) Query: 160 SAATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRP 219 A G+ T ML G V + + V Q I+ A G R I Sbjct: 208 EATGYGLVYFT-EAMLKRHGMGFEGMRVSVSG-SGNVAQYAIEKAMEFGARVITASDSSG 265 Query: 220 DIQKLSDRLKS 230 + S K Sbjct: 266 TVVDESGFTKE 276 >4XIJ-A nrPDB Length = 275 Score = 32.4 bits (72), Expect = 0.31, Method: Composition-based stats. Identities = 32/127 (25%), Positives = 45/127 (35%), Gaps = 12/127 (9%) Query: 110 AQVVAVGSNVTGLK---PGDWVIPANAGLGTWRTEAVFSEEALIQVPSDIPLQSAATLGV 166 V A+G GL PG + A T R + V S L+++P+ A V Sbjct: 58 GLVSALGPEWVGLSVTMPGKFAALEFADQRTDRAQLVGSANTLVRMPTG--GWRADNTDV 115 Query: 167 NPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSD 226 + T GDS + S AV+ +A R V RD +L D Sbjct: 116 DGVTG-------ALGTAGDSALVIGSGGTAPAAVVALAELGVQRITIVARDEGKASRLVD 168 Query: 227 RLKSLGA 233 + GA Sbjct: 169 LARRCGA 175 >4LK4-A nrPDB Length = 357 Score = 32.4 bits (72), Expect = 0.32, Method: Composition-based stats. Identities = 25/159 (15%), Positives = 51/159 (32%), Gaps = 22/159 (13%) Query: 21 LPASGCHGPAASSYSASAEPARVRALVYGHHGDPA---KVVELKNLELAAVRGSDVRVKM 77 LPA GPA + + P V P +++ +++L + + ++ Sbjct: 115 LPAITLAGPATRTSLPALTPLTVAGWGITVQSKPPQFTPILQEVDVDLVSQSLCQIVMQ- 173 Query: 78 LAAPINPSDIN-----MIQGNYGFLPELPAVG--GNEGVAQVVAVGSNVTGLKPGDWVIP 130 +P+ N + + + P V G E + V GD Sbjct: 174 HGISSDPNSTNFCAARLTKDSCQGDAGGPIVVKTGREQLGIV----------SWGDEQCA 223 Query: 131 ANAGLGTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPC 169 G + + F + + + + + A LG+ P Sbjct: 224 KTGTYGVYTNVSYFRD-WITKHTNQLSYDQVANLGIRPL 261 >3PWS-A nrPDB Length = 366 Score = 32.4 bits (72), Expect = 0.34, Method: Composition-based stats. Identities = 17/120 (14%), Positives = 35/120 (29%), Gaps = 11/120 (9%) Query: 184 GDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELR 243 G +V + VG Q+ L I K+ + A + ++ Sbjct: 2 GYTVAVVGATGAVG---AQMIKML-------EESTLPIDKIRYLASARSAGKSLKFKDQD 51 Query: 244 RPEMKNFFKDMPQPRLALNCVGGKSSTELLRQLARGGTMVTYGGMAKQPVVASVSLLIFK 303 + +AL G +S + + G +V + V L++ + Sbjct: 52 ITIEETTETAFEGVDIALFSAGSSTSAKYAPYAVKAG-VVVVDNTSYFRQNPDVPLVVPE 110 >2AS0-A nrPDB Length = 396 Score = 32.0 bits (71), Expect = 0.38, Method: Composition-based stats. Identities = 23/124 (18%), Positives = 42/124 (33%), Gaps = 9/124 (7%) Query: 181 LQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEH---VI 237 +QPGD V+ + +G I A A I + + I+ + K G E I Sbjct: 215 VQPGDRVLDVFTYTGG--FAIHAAIAGADEVIGIDKSPRAIETAKENAKLNGVEDRMKFI 272 Query: 238 TEEELRRPEMKNFFKDMPQPRLALNCVGGKSSTELLRQLARGGTMVTYGGMAKQPVVASV 297 EM+ K + + + + + + + L G A +V Sbjct: 273 VGSAFE--EMEKLQKKGEKFDIVV--LDPPAFVQHEKDLKAGLRAYFNVNFAGLNLVKDG 328 Query: 298 SLLI 301 +L+ Sbjct: 329 GILV 332 >4CQM-B nrPDB Length = 244 Score = 32.0 bits (71), Expect = 0.38, Method: Composition-based stats. Identities = 18/87 (20%), Positives = 34/87 (39%), Gaps = 9/87 (10%) Query: 185 DSVIQNASNS-GVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELR 243 D V S G+G+AV Q+ A G R + R +++ LG +H+ ++ Sbjct: 9 DKVCAVFGGSRGIGRAVAQLMARKGYRLAVIAR---NLEGAKAAAGDLGGDHLAFSCDVA 65 Query: 244 RP-----EMKNFFKDMPQPRLALNCVG 265 + + K + + +N G Sbjct: 66 KEHDVQNTFEELEKHLGRVNFLVNAAG 92 >5ITV-A nrPDB Length = 255 Score = 32.0 bits (71), Expect = 0.41, Method: Composition-based stats. Identities = 13/84 (15%), Positives = 29/84 (34%), Gaps = 3/84 (3%) Query: 185 DSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHV---ITEEE 241 +V+ SG+G A +Q + D + + + + V IT+E Sbjct: 8 KTVLITGGASGIGYAAVQAFLGQQANVVVADIDEAQGEAMVRKENNDRLHFVQTDITDEA 67 Query: 242 LRRPEMKNFFKDMPQPRLALNCVG 265 + +++ + +N G Sbjct: 68 ACQHAVESAVHTFGGLDVLINNAG 91 >4FC7-A nrPDB Length = 277 Score = 32.0 bits (71), Expect = 0.42, Method: Composition-based stats. Identities = 20/105 (19%), Positives = 37/105 (35%), Gaps = 7/105 (6%) Query: 171 AYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKS 230 AYR L + L+ SG+G + +I G T+ R P + + +L Sbjct: 15 AYRHLFCPDLLRD-KVAFITGGGSGIGFRIAEIFMRHGCHTVIASRSLPRVLTAARKLAG 73 Query: 231 LGAEHVIT-EEELRRPE-----MKNFFKDMPQPRLALNCVGGKSS 269 + ++R P + K+ + + +NC G Sbjct: 74 ATGRRCLPLSMDVRAPPAVMAAVDQALKEFGRIDILINCAAGNFL 118 >3PPI-A nrPDB Length = 281 Score = 32.0 bits (71), Expect = 0.46, Method: Composition-based stats. Identities = 24/105 (22%), Positives = 36/105 (34%), Gaps = 1/105 (0%) Query: 183 PGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEEL 242 G S I + G+G+A ++ A GL + + L+D L + AE V T Sbjct: 29 EGASAIVSGGAGGLGEATVRRLHADGLGVVIADLAAEKGKALADELGNR-AEFVSTNVTS 87 Query: 243 RRPEMKNFFKDMPQPRLALNCVGGKSSTELLRQLARGGTMVTYGG 287 + RL V R + R G+ GG Sbjct: 88 EDSVLAAIEAANQLGRLRYAVVAHGGFGVAQRIVQRDGSPADMGG 132 >4INE-A nrPDB Length = 454 Score = 32.0 bits (71), Expect = 0.47, Method: Composition-based stats. Identities = 17/114 (14%), Positives = 38/114 (33%), Gaps = 9/114 (7%) Query: 175 LMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAE 234 + F +PG +++ G G Q+A G+ + + +RL Sbjct: 233 IKRFGDFKPGQTMLDIGVGIGGG--ARQVADEFGVHVHGIDLSSNMLAIALERLHEEKDS 290 Query: 235 HVITEEELRRPEMKNFFKDMPQPRLALNCV-----GGKSSTELLRQLARGGTMV 283 V + + F + + +C+ K + + + L GG ++ Sbjct: 291 RVKYS--ITDALVYQFEDNSFDYVFSRDCIQHIPDTEKLFSRIYKALKPGGKVL 342 >4IIN-A nrPDB Length = 271 Score = 32.0 bits (71), Expect = 0.48, Method: Composition-based stats. Identities = 17/101 (16%), Positives = 35/101 (34%), Gaps = 5/101 (4%) Query: 184 GDSVIQNASNSGVGQAVIQIAAALGLRT-INVVRDRPDIQKLSDRLKSLGAEHVI----T 238 G +V+ ++ G+G + + A++GL+ IN + L + L+ G + + Sbjct: 29 GKNVLITGASKGIGAEIAKTLASMGLKVWINYRSNAEVADALKNELEEKGYKAAVIKFDA 88 Query: 239 EEELRRPEMKNFFKDMPQPRLALNCVGGKSSTELLRQLARG 279 E E L G +L ++ Sbjct: 89 ASESDFIEAIQTIVQSDGGLSYLVNNAGVVRDKLAIKMKTE 129 >4AVY-A nrPDB Length = 242 Score = 31.6 bits (70), Expect = 0.51, Method: Composition-based stats. Identities = 15/88 (17%), Positives = 32/88 (36%), Gaps = 9/88 (10%) Query: 180 QLQPGDSVIQNASNSGVGQA-VIQIAAALGLRTIN-VVRDRPDIQKLSDRLKSLGAEHVI 237 + G V+ +SG+G A +Q A LG + + R++ + Sbjct: 7 DIYAGQQVLVTGGSSGIGAAIAMQFAE-LGAEVVALGLDADGVHAPRHPRIRREELDIT- 64 Query: 238 TEEELRRPEMKNFFKDMPQPRLALNCVG 265 ++ F+ +P+ + +N G Sbjct: 65 -----DSQRLQRLFEALPRLDVLVNNAG 87 >5BP7-A nrPDB Length = 271 Score = 31.6 bits (70), Expect = 0.53, Method: Composition-based stats. Identities = 28/139 (20%), Positives = 50/139 (35%), Gaps = 6/139 (4%) Query: 152 VPSDIPLQSAATLGVNPCTAYRMLMDFEQLQ--PGDSVIQNASNSGVGQAVIQIAAALGL 209 +P + +A NP T ++ L+ PG V+ S S G+ + A G+ Sbjct: 26 IPRIFTITESAHRIHNPITPEKLTTLGAALRLEPGTRVLDLGSGS--GEMLCTWARDHGI 83 Query: 210 RTINVVRDRPDIQKLSDRLKSLG-AEHVITEEELRRPEMKNFFKDMPQPRLALNCVGG-K 267 + + + R + LG A+ V + + + A GG Sbjct: 84 IGTGIDMSQLFTAQAKLRAEELGVADRVTFIHGDASGYVSDDKAGVAACVGATWIGGGVA 143 Query: 268 SSTELLRQLARGGTMVTYG 286 + ELL + R G ++ G Sbjct: 144 GTIELLARSLRPGGIILIG 162 >6GBN-A nrPDB Length = 438 Score = 31.6 bits (70), Expect = 0.60, Method: Composition-based stats. Identities = 17/84 (20%), Positives = 28/84 (33%), Gaps = 12/84 (14%) Query: 187 VIQNASNSGVGQAVIQIAAALGLRTINV----------VRDRPDIQKLSDRLKSLGAEHV 236 V A VG+ G R I D +++K++D +K A+ V Sbjct: 221 VAVVAGYGDVGKGSAASLRGAGARVIVTEIDPICALQAAMDGYEVKKMADAVKR--ADIV 278 Query: 237 ITEEELRRPEMKNFFKDMPQPRLA 260 +T + FK M + Sbjct: 279 VTATGNKNIITGEHFKAMRDKVIV 302 >4QUK-A nrPDB Length = 319 Score = 31.3 bits (69), Expect = 0.68, Method: Composition-based stats. Identities = 10/49 (20%), Positives = 21/49 (42%) Query: 187 VIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEH 235 V ++ + ++++ G VRD D +K+ +K GA+ Sbjct: 3 VCVTGASGYIASWLVRLLLHRGYTVKATVRDPNDPKKVDHLVKLDGAKE 51 >2ISQ-A nrPDB Length = 320 Score = 31.3 bits (69), Expect = 0.75, Method: Composition-based stats. Identities = 19/64 (29%), Positives = 31/64 (48%), Gaps = 5/64 (7%) Query: 177 DFEQLQPGDSVIQ--NASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAE 234 ++PG+SV+ + N+GVG A AAA G + I + ++ L + G E Sbjct: 57 KKGLIKPGESVLIEPTSGNTGVGLAFT--AAAKGYKLIITMPASMSTERRIILL-AFGVE 113 Query: 235 HVIT 238 V+T Sbjct: 114 LVLT 117 >3CJR-A nrPDB Length = 254 Score = 31.3 bits (69), Expect = 0.80, Method: Composition-based stats. Identities = 17/64 (26%), Positives = 24/64 (37%), Gaps = 4/64 (6%) Query: 170 TAYRMLMDFE-QLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRL 228 T L L+PGD V+ + SGV A LG + + V D + + Sbjct: 106 TTRLALKALARHLRPGDKVLDLGTGSGVLAIA---AEKLGGKALGVDIDPMVLPQAEANA 162 Query: 229 KSLG 232 K G Sbjct: 163 KRNG 166 >4OMU-A nrPDB Length = 283 Score = 30.9 bits (68), Expect = 0.88, Method: Composition-based stats. Identities = 17/116 (14%), Positives = 29/116 (25%), Gaps = 14/116 (12%) Query: 183 PGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEEL 242 G ++ + V + I A + R ++L+ LG Sbjct: 118 AGKRILILGAGGAVRGVLEPILAHKPQSLVIANRTVEKAEQLAREFDELG---------- 167 Query: 243 RRPEMKNFFKDMPQPRLALNCVGGKSSTEL---LRQLARGGTMVTYGGMAKQPVVA 295 F + +N + EL L G V Y M + Sbjct: 168 -PVVASGFAWLQEPVDVIINATSASLAGELPPIADSLVEAGRTVCYDMMYGKEPTP 222 >1NKV-A nrPDB Length = 256 Score = 30.9 bits (68), Expect = 0.94, Method: Composition-based stats. Identities = 22/115 (19%), Positives = 39/115 (33%), Gaps = 5/115 (4%) Query: 172 YRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSL 231 Y L +++PG ++ S S G+ + A G+ + + R + L Sbjct: 25 YATLGRVLRMKPGTRILDLGSGS--GEMLCTWARDHGITGTGIDMSSLFTAQAKRRAEEL 82 Query: 232 GAEHVITEEELRRP-EMKNFFKDMPQPRLALNCVGG--KSSTELLRQLARGGTMV 283 G + + N D+ A GG + L + L GG M+ Sbjct: 83 GVSERVHFIHNDAAGYVANEKCDVAACVGATWIAGGFAGAEELLAQSLKPGGIML 137 >3WYE-A nrPDB Length = 256 Score = 30.9 bits (68), Expect = 0.95, Method: Composition-based stats. Identities = 11/91 (12%), Positives = 30/91 (32%), Gaps = 5/91 (5%) Query: 188 IQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHV-----ITEEEL 242 + + G+G+A+ G + + ++ + G V +++ + Sbjct: 6 LVTGAGQGIGKAIALRLVKDGFAVAIADYNDATAKAVASEINQAGGHAVAVKVDVSDRDQ 65 Query: 243 RRPEMKNFFKDMPQPRLALNCVGGKSSTELL 273 ++ K + + +N G LL Sbjct: 66 VFAAVEQARKTLGGFDVIVNNAGIAQIKPLL 96 >4LAT-A nrPDB Length = 265 Score = 30.9 bits (68), Expect = 0.98, Method: Composition-based stats. Identities = 9/49 (18%), Positives = 18/49 (36%), Gaps = 5/49 (10%) Query: 159 QSAATLGVNPCTAYRMLMDFEQLQ-----PGDSVIQNASNSGVGQAVIQ 202 ++ TA + L++ + G +V SG G + +Q Sbjct: 1 DRGESITAVGSTALQPLVEVAADEFGTIHVGKTVNVQGGGSGTGLSQVQ 49 >5TC4-A nrPDB Length = 316 Score = 30.9 bits (68), Expect = 1.0, Method: Composition-based stats. Identities = 21/157 (13%), Positives = 48/157 (30%), Gaps = 10/157 (6%) Query: 158 LQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRT-----I 212 L + L P + ++ G +V+ + VG + + G Sbjct: 133 LDQYSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTDGAHERPGGDA 192 Query: 213 NVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFFKDMPQP-RLALNCVGGKSST- 270 V K + ++ A+ VI+ + + K+ + +N V + Sbjct: 193 TVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEGAAVIDVGINRVHDPVTAK 252 Query: 271 -ELLRQLARGGTMVTYGGMAKQPVVASVSL--LIFKD 304 +L+ + G G + P ++ K+ Sbjct: 253 PKLVGDVDFEGVRQKAGYITPVPGGVGPMTVAMLMKN 289 >6NRP-A nrPDB Length = 263 Score = 30.5 bits (67), Expect = 1.1, Method: Composition-based stats. Identities = 13/85 (15%), Positives = 38/85 (44%), Gaps = 7/85 (8%) Query: 186 SVIQNASNSGVGQA-VIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGA------EHVIT 238 ++ S+ G+G+A +Q+A A T++ + + +++ +++LG V Sbjct: 26 RILVTGSSRGIGKAIALQLAKAGFDVTVHARSRQAEAEQVVQEIQALGQNSHYLMFDVNE 85 Query: 239 EEELRRPEMKNFFKDMPQPRLALNC 263 + +++ ++ + + LN Sbjct: 86 RQTVQQILEQDVEQHGGFYGVVLNA 110 >4ER3-A nrPDB Length = 352 Score = 30.5 bits (67), Expect = 1.1, Method: Composition-based stats. Identities = 26/140 (18%), Positives = 48/140 (34%), Gaps = 21/140 (15%) Query: 188 IQNASNSGVGQAVIQIAAALGLR---TINVVRDRPDIQKLSDR-----LKSLG---AEHV 236 + SGVGQ V+Q+AAA + + + DR +K G AE+ Sbjct: 159 LFVDLGSGVGQVVLQVAAATNCKHHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYT 218 Query: 237 ITEEELRRPEMKNFFKDMPQPRLALNCVGGKSSTELLRQ----LARGGTMVTYGGMAKQP 292 + + E + + N G L++ + GG +V + +P Sbjct: 219 LERGDFLSEEWRERIAN-TSVIFVNNFAFGPEVDHQLKERFANMKEGGRIV-----SSKP 272 Query: 293 VVASVSLLIFKDLKLRGFWL 312 + ++L G + Sbjct: 273 FAPLNFRINSRNLSDIGTIM 292 >3UWP-A nrPDB Length = 438 Score = 30.5 bits (67), Expect = 1.1, Method: Composition-based stats. Identities = 26/140 (18%), Positives = 48/140 (34%), Gaps = 21/140 (15%) Query: 188 IQNASNSGVGQAVIQIAAALGLR---TINVVRDRPDIQKLSDR-----LKSLG---AEHV 236 + SGVGQ V+Q+AAA + + + DR +K G AE+ Sbjct: 176 LFVDLGSGVGQVVLQVAAATNCKHHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYT 235 Query: 237 ITEEELRRPEMKNFFKDMPQPRLALNCVGGKSSTELLRQ----LARGGTMVTYGGMAKQP 292 + + E + + N G L++ + GG +V + +P Sbjct: 236 LERGDFLSEEWRERIAN-TSVIFVNNFAFGPEVDHQLKERFANMKEGGRIV-----SSKP 289 Query: 293 VVASVSLLIFKDLKLRGFWL 312 + ++L G + Sbjct: 290 FAPLNFRINSRNLSDIGTIM 309 >1YXM-A nrPDB Length = 303 Score = 30.5 bits (67), Expect = 1.2, Method: Composition-based stats. Identities = 11/51 (21%), Positives = 23/51 (45%) Query: 180 QLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKS 230 L G I +G+G+A+++ LG + R ++ +D L++ Sbjct: 14 GLLQGQVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAADELQA 64 >1BDB-A nrPDB Length = 277 Score = 30.5 bits (67), Expect = 1.4, Method: Composition-based stats. Identities = 9/43 (20%), Positives = 21/43 (48%) Query: 183 PGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLS 225 G++V+ SG+G+A++ A G + + + + +L Sbjct: 4 KGEAVLITGGASGLGRALVDRFVAEGAKVAVLDKSAERLAELE 46 >6CU3-A nrPDB Length = 336 Score = 30.5 bits (67), Expect = 1.4, Method: Composition-based stats. Identities = 14/92 (15%), Positives = 33/92 (35%), Gaps = 4/92 (4%) Query: 171 AYR-MLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLK 229 AY+ ++ + L V+ +G + AA G + + + I K + Sbjct: 38 AYKNAILQNKHLFKDKVVLDIGCGTG---ILCLFAAKAGAKRVIGIDMSDIIDKARQIVS 94 Query: 230 SLGAEHVITEEELRRPEMKNFFKDMPQPRLAL 261 G HVI + + ++ + + + + Sbjct: 95 DNGYSHVIELIKGKVEDIAQLPFGIEKVDIII 126 >3UF0-A nrPDB Length = 273 Score = 30.1 bits (66), Expect = 1.5, Method: Composition-based stats. Identities = 12/86 (13%), Positives = 28/86 (32%), Gaps = 3/86 (3%) Query: 183 PGDSVIQNASNSGVGQAVIQIAAALGLRTIN---VVRDRPDIQKLSDRLKSLGAEHVITE 239 G + + + SG+G+A+ A G + + +++D S A Sbjct: 30 AGRTAVVTGAGSGIGRAIAHGYARAGAHVLAWGRTDGVKEVADEIADGGGSAEAVVADLA 89 Query: 240 EELRRPEMKNFFKDMPQPRLALNCVG 265 + + + + +N G Sbjct: 90 DLEGAANVAEELAATRRVDVLVNNAG 115 >3RUW-A nrPDB Length = 543 Score = 30.1 bits (66), Expect = 1.7, Method: Composition-based stats. Identities = 13/90 (14%), Positives = 28/90 (31%), Gaps = 4/90 (4%) Query: 202 QIAAALGLRTINVVRDRPDIQKLSDRL---KSLGAEHVITEEELRRPEMKNFFKDMPQPR 258 ++A A G I + L + + + +I EE + P+ Sbjct: 316 KLAKATGANVIAAIAALSAQDLGDAGLVEERKISGDSMIFVEECKHPKAVTMLIRGTTEH 375 Query: 259 LALNCV-GGKSSTELLRQLARGGTMVTYGG 287 + + ++ G +V+ GG Sbjct: 376 VIEEVARAVDDAVGVVGCTIEDGRIVSGGG 405 >3R75-A nrPDB Length = 645 Score = 30.1 bits (66), Expect = 1.7, Method: Composition-based stats. Identities = 23/125 (18%), Positives = 44/125 (35%), Gaps = 6/125 (4%) Query: 193 NSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLG-AEHVITEEELRRPEMKNFF 251 G+ ++A G R + V + ++ +L SLG A V + + Sbjct: 431 GGRQGEMADELAELSGCRALIVDAEDHFTAMIAQQLSSLGLATEVCGVHDAVDLARYDVV 490 Query: 252 KDMPQPRLALNCVGGKSSTEL---LRQLARGGTMVTYGGMAKQPVVASVS-LLIFKDLKL 307 P P + G L LR L G ++ Q + A + L+ +++ Sbjct: 491 VMGPGPGDPSDA-GDPRIARLYAWLRHLIDEGKPFMAVCLSHQILNAILGIPLVRREVPN 549 Query: 308 RGFWL 312 +G + Sbjct: 550 QGIQV 554 >1URG-A nrPDB Length = 402 Score = 30.1 bits (66), Expect = 1.8, Method: Composition-based stats. Identities = 29/166 (17%), Positives = 49/166 (29%), Gaps = 18/166 (10%) Query: 177 DFEQLQPGDSVIQNASNSG-----VGQAVIQIAAALGLRTINVV-RDRPDIQKLSDRLKS 230 + L G ++ + +G V Q Q A A G + I V P + Sbjct: 22 EASALPKGQTITVWSWQTGPELQDVKQIAAQWAKAHGDKVIVVDQSSNPKGFQFYATAAR 81 Query: 231 LGA--EHVITEEELRRPEMKNFFKDMPQPRLALNCVGGKSSTELLRQLARGGTMVTYGGM 288 G + V P P LN G + + + GTM + Sbjct: 82 TGKGPDVVFGMPHDNNGVFAEEGLMAPVPSGVLNT--GLYAPNTIDAIKVNGTMYSV--- 136 Query: 289 AKQPVVASVSLLIFKDLKLRGF--WLSQWKKDHSPDQFKELILTLC 332 PV V+ + + + +++ KD + F L Sbjct: 137 ---PVSVQVAAIYYNKKLVPQPPQTWAEFVKDANAHGFMYDQANLY 179 >4R1T-A nrPDB Length = 337 Score = 29.7 bits (65), Expect = 1.8, Method: Composition-based stats. Identities = 12/79 (15%), Positives = 28/79 (35%), Gaps = 3/79 (3%) Query: 184 GDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSL-GAEHVITEEEL 242 G V + + +++I G VR+ D + L+ L GA+ +T + Sbjct: 10 GQVVCVTGAGGFIASWLVKILLEKGYTVRGTVRNPDDPKNGH--LRELEGAKERLTLCKA 67 Query: 243 RRPEMKNFFKDMPQPRLAL 261 + ++ + + Sbjct: 68 DLLDYQSLREAINGCDGVF 86 >2Q2Q-A nrPDB Length = 255 Score = 29.7 bits (65), Expect = 1.9, Method: Composition-based stats. Identities = 15/88 (17%), Positives = 30/88 (34%), Gaps = 7/88 (7%) Query: 183 PGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEEL 242 G + + S SG+G + Q+ A G I + L++ + G + V +L Sbjct: 3 KGKTALVTGSTSGIGLGIAQVLARAGAN-IVLNGFGDPAPALAEIARH-GVKAVHHPADL 60 Query: 243 RRPEMKNFF-----KDMPQPRLALNCVG 265 ++ + +N G Sbjct: 61 SDVAQIEALFALAEREFGGVDILVNNAG 88 >1DB3-A nrPDB Length = 372 Score = 29.7 bits (65), Expect = 1.9, Method: Composition-based stats. Identities = 12/27 (44%), Positives = 16/27 (59%), Gaps = 1/27 (3%) Query: 105 GNEGVAQVVAV-GSNVTGLKPGDWVIP 130 G E VV+V G + G+KPGD +I Sbjct: 279 GVEEKGIVVSVTGHDAPGVKPGDVIIA 305 >1GEG-A nrPDB Length = 256 Score = 29.7 bits (65), Expect = 2.0, Method: Composition-based stats. Identities = 9/83 (10%), Positives = 28/83 (33%), Gaps = 5/83 (6%) Query: 188 IQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHV-----ITEEEL 242 + + G+G+A+ G + + ++ + G V +++ + Sbjct: 6 LVTGAGQGIGKAIALRLVKDGFAVAIADYNDATAKAVASEINQAGGHAVAVKVDVSDRDQ 65 Query: 243 RRPEMKNFFKDMPQPRLALNCVG 265 ++ K + + +N G Sbjct: 66 VFAAVEQARKTLGGFDVIVNNAG 88 >1DOH-A nrPDB Length = 283 Score = 29.7 bits (65), Expect = 2.0, Method: Composition-based stats. Identities = 12/98 (12%), Positives = 34/98 (34%), Gaps = 4/98 (4%) Query: 183 PGDSVIQNASNSGVG-QAVIQIAAALGLRTI-NVVRDRPDIQKLSDRLKSLGAE-HVITE 239 G + + G+G + +++ G + I N +++ +K G++ + Sbjct: 28 EGKVALVTGAGRGIGREMAMELGR-RGCKVIVNYANSTESAEEVVAAIKKNGSDAACVKA 86 Query: 240 EELRRPEMKNFFKDMPQPRLALNCVGGKSSTELLRQLA 277 ++ F++ + L+ V S + Sbjct: 87 NVGVVEDIVRMFEEAVKIFGKLDIVCSNSGVVSFGHVK 124 >2NNL-D nrPDB Length = 337 Score = 29.7 bits (65), Expect = 2.0, Method: Composition-based stats. Identities = 12/77 (15%), Positives = 29/77 (37%) Query: 185 DSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRR 244 ++V ++ +G ++ G VRD +++K+ L AE +T + Sbjct: 6 ETVCVTGASGFIGSWLVMRLLERGYTVRATVRDPTNVKKVKHLLDLPKAETHLTLWKADL 65 Query: 245 PEMKNFFKDMPQPRLAL 261 + +F + + Sbjct: 66 ADEGSFDEAIKGCTGVF 82 >6DXF-A nrPDB Length = 386 Score = 29.7 bits (65), Expect = 2.1, Method: Composition-based stats. Identities = 37/210 (17%), Positives = 70/210 (33%), Gaps = 11/210 (5%) Query: 102 AVGGNEGVAQVVAVGSNVTGLKPGDWVIPANAGLGTWRTEAVFSEEALIQVPSDIPLQSA 161 G A V V ++ PG V+ A + + T T SE L + Sbjct: 155 YQQGCSAGATVTRVAKDLAENNPGARVLVACSEV-TAVTFRAPSETHLDGLVGAALFGDG 213 Query: 162 ATLGVNPCT---AYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDR 218 A + + L + G V+ ++ + +G GL + Sbjct: 214 AAALIIGSNPTPVEKPLFEVHW--SGQCVLPDSDGAILGHL-----REAGLVFHLLKDVP 266 Query: 219 PDIQKLSDRLKSLGAEHVITEEELRRPEMKNFFKDMPQPRLALNCVGGKSSTELLRQLAR 278 I K ++L + ++V + +E F+ P L+ V K + R A Sbjct: 267 GIISKNIEKLLAEPLDYVKSVDEASPAYTDLFWVVHPGGPAILDQVEAKLKLDKDRMQAT 326 Query: 279 GGTMVTYGGMAKQPVVASVSLLIFKDLKLR 308 + YG M+ V+ + + + ++L Sbjct: 327 RDVLAQYGNMSSASVLFVLDQMRKRSVELN 356 >6ACF-A nrPDB Length = 367 Score = 29.3 bits (64), Expect = 2.5, Method: Composition-based stats. Identities = 13/75 (17%), Positives = 23/75 (30%), Gaps = 16/75 (21%) Query: 171 AYRMLMDFEQLQ------PGDSVIQNASNSGVGQAVIQIAAAL---GLRTINVVRDRPDI 221 YR + + G V GVG + L G + I ++ + Sbjct: 154 VYRGMKAAAKEAFGSDSLEGKVVAVQ----GVGNVAYHLCRHLHEEGAKLIVTDINKEAV 209 Query: 222 QKLSDRLKSLGAEHV 236 + + GA+ V Sbjct: 210 ARAVE---EFGAKAV 221 >3NJ4-A nrPDB Length = 435 Score = 29.3 bits (64), Expect = 2.5, Method: Composition-based stats. Identities = 9/52 (17%), Positives = 15/52 (28%) Query: 174 MLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLS 225 + + V A VG+ Q G R I D + + + Sbjct: 205 GIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAA 256 >3RWB-A nrPDB Length = 247 Score = 29.3 bits (64), Expect = 2.6, Method: Composition-based stats. Identities = 11/87 (12%), Positives = 30/87 (34%), Gaps = 6/87 (6%) Query: 183 PGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRD----RPDIQKLSDRLKSLGAEHVIT 238 G + + + G+G+A+ AA G I + + + + +++ A+ I+ Sbjct: 5 AGKTALVTGAAQGIGKAIAARLAADGATVIVSDINAEGAKAAAASIGKKARAIAAD--IS 62 Query: 239 EEELRRPEMKNFFKDMPQPRLALNCVG 265 + + + +N Sbjct: 63 DPGSVKALFAEIQALTGGIDILVNNAS 89 >1P77-A nrPDB Length = 272 Score = 29.3 bits (64), Expect = 2.6, Method: Composition-based stats. Identities = 9/93 (9%), Positives = 29/93 (31%), Gaps = 5/93 (5%) Query: 175 LMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAE 234 L L+P V+ + ++ + A + R ++L++R + G Sbjct: 110 LQRLNWLRPNQHVLILGAGGATKGVLLPLLQAQ-QNIVLANRTFSKTKELAERFQPYGNI 168 Query: 235 HVITEEELRRPEMKNFFK----DMPQPRLALNC 263 ++ + + + +++ Sbjct: 169 QAVSMDSIPLQTYDLVINATSAGLSGGTASVDA 201 >6GCS-A nrPDB Length = 728 Score = 29.3 bits (64), Expect = 2.7, Method: Composition-based stats. Identities = 13/105 (12%), Positives = 26/105 (24%), Gaps = 2/105 (1%) Query: 204 AAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFFKDMPQPRLALNC 263 A+ G I + + LGA+ V + + + + Sbjct: 526 ASRAGAYDIGFTPSDEASKTTPKMVWLLGADEVAASDIPADAFVVYQGHNGDVGAQFADV 585 Query: 264 V--GGKSSTELLRQLARGGTMVTYGGMAKQPVVASVSLLIFKDLK 306 V G + + + G P A I + + Sbjct: 586 VLPGAAYTEKAGTYVNTEGRSQISRAATGPPGGAREDWKILRAVS 630 >1J49-A nrPDB Length = 333 Score = 29.3 bits (64), Expect = 2.8, Method: Composition-based stats. Identities = 13/48 (27%), Positives = 21/48 (43%), Gaps = 1/48 (2%) Query: 185 DSVIQNASNSGVGQAVIQIAAALGLRTINVVRDR-PDIQKLSDRLKSL 231 D V+ +GQ +QI G + I R P+++K + SL Sbjct: 146 DQVVGVVGTGHIGQVFMQIMEGFGAKVITYDIFRNPELEKKGYYVDSL 193 >2AE2-A nrPDB Length = 260 Score = 29.3 bits (64), Expect = 3.0, Method: Composition-based stats. Identities = 10/69 (14%), Positives = 28/69 (40%) Query: 183 PGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEEL 242 G + + + G+G +++ A+LG R++ ++ + +S G + + +L Sbjct: 8 EGCTALVTGGSRGIGYGIVEELASLGASVYTCSRNQKELNDCLTQWRSKGFKVEASVCDL 67 Query: 243 RRPEMKNFF 251 + Sbjct: 68 SSRSERQEL 76 >3L07-A nrPDB Length = 285 Score = 28.9 bits (63), Expect = 3.2, Method: Composition-based stats. Identities = 20/131 (15%), Positives = 44/131 (33%), Gaps = 7/131 (5%) Query: 174 MLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGA 233 ML ++ G + +++ VG+ V Q+ L + R S K A Sbjct: 151 MLREYGIKTEGAYAVVVGASNVVGKPVSQL--LLNAKATVTTCHRFTTDLKSHTTK---A 205 Query: 234 EHVITEEELRRPEMKNFFKDMPQP-RLALNCVGGKSSTELLRQLARGGTMVTYGGMAKQP 292 + +I + K+ + +N V GK + + A + + Sbjct: 206 DILIVAVGKPNFITADMVKEGAVVIDVGINHVDGKIVGD-VDFAAVKDKVAAITPVPGGV 264 Query: 293 VVASVSLLIFK 303 +++ L++ Sbjct: 265 GPMTITELLYN 275 >1E3W-A nrPDB Length = 261 Score = 28.9 bits (63), Expect = 3.3, Method: Composition-based stats. Identities = 12/87 (13%), Positives = 33/87 (37%), Gaps = 2/87 (2%) Query: 188 IQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKS--LGAEHVITEEELRRP 245 + SG+G + + G + + + + + +L + A +T E+ + Sbjct: 14 VITGGASGLGLSTAKRLVGQGATAVLLDVPNSEGETEAKKLGGNCIFAPANVTSEKEVQA 73 Query: 246 EMKNFFKDMPQPRLALNCVGGKSSTEL 272 + + + +A+NC G + + Sbjct: 74 ALTLAKEKFGRIDVAVNCAGIAVAIKT 100 >2CDH-G nrPDB Length = 244 Score = 28.9 bits (63), Expect = 4.0, Method: Composition-based stats. Identities = 16/98 (16%), Positives = 42/98 (42%), Gaps = 7/98 (7%) Query: 187 VIQNASNSGVGQAVIQIAAALGLRT-INVVRDRPDIQKLSDRLKSLGAEHV-----ITEE 240 V+ ++ G+G+A+ G + +N R +++S ++++ G + + +++E Sbjct: 4 VVVTGASRGIGKAIALSLGKAGCKVLVNYARSAKAAEEVSKQIEAYGGQAITFGGDVSKE 63 Query: 241 ELRRPEMKNFFKDMPQPRLALNCVGGKSSTELLRQLAR 278 MK + +N G + LL ++ + Sbjct: 64 ADVEAMMKTAIDAWGTIDVVVNNAGI-TRDTLLIRMKK 100 >4DIO-A nrPDB Length = 405 Score = 28.9 bits (63), Expect = 4.0, Method: Composition-based stats. Identities = 17/75 (22%), Positives = 27/75 (36%), Gaps = 5/75 (6%) Query: 171 AYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKS 230 A M+M P + + G I A LG VV +++ S Sbjct: 177 ALPMMMTAAGTVPAAKIFVMGAGVA-GLQAIATARRLGA----VVSATDVRPAAKEQVAS 231 Query: 231 LGAEHVITEEELRRP 245 LGA+ + E+E + Sbjct: 232 LGAKFIAVEDEEFKA 246 >3GIQ-A nrPDB Length = 480 Score = 28.6 bits (62), Expect = 4.2, Method: Composition-based stats. Identities = 31/167 (18%), Positives = 62/167 (37%), Gaps = 28/167 (16%) Query: 84 PSDINMIQGNYGFLPEL---PAVGGNEGVAQVVAVG-------SNVTGLKPGDWVIPANA 133 +D+ + G + EL PA + ++VA G ++ ++ D + Sbjct: 26 RADLGVRDGRIAAIGELGAHPARHAWDASGKIVAPGFIDVHGHDDLMFVEKPDLRWKTSQ 85 Query: 134 GLGTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCT-------AYRMLMDFEQLQPGDS 186 G+ T V + P+ +P +AA L + T AY +D ++ Sbjct: 86 GITT----VVVGNCGVSAAPAPLPGNTAAALALLGETPLFADVPAYFAALDAQRP----- 136 Query: 187 VIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGA 233 + N + VG A +++AA + ++ +Q + GA Sbjct: 137 -MINVAA-LVGHANLRLAAMRDPQAAPTAAEQQAMQDMLQAALEAGA 181 >4PDS-A nrPDB Length = 347 Score = 28.6 bits (62), Expect = 5.0, Method: Composition-based stats. Identities = 33/206 (16%), Positives = 67/206 (32%), Gaps = 30/206 (14%) Query: 172 YRMLMDFEQLQPGDSVIQNASNSGVG-----------QAVIQIAAALGLR-------TIN 213 Y M+M+F + GD + A++ VG I+ ++G+ I Sbjct: 104 YYMVMEF--VSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSMGISHRDLKPDNIL 161 Query: 214 VVRDRPDIQKLSDR--LKSLGAEHVITEEELRRPEMKNFFKDMPQPRLALNCVGGKSSTE 271 + +D P + K++ K G + + ++ + ++ Sbjct: 162 IEQDDPVLVKITAFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSPDEYEERNEYS 221 Query: 272 LLRQLARGGTMVTYGGMAKQPVVASVSLLIFKDLKLRGFWLSQWKKDHS-PDQFKELILT 330 L + G +V P S ++K + RG + KD ++ ++ I + Sbjct: 222 SLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIG-RGSYHEGPLKDFRISEEARDFIDS 280 Query: 331 LCDL------IRRGQLTAPACSQVPL 350 L + L P PL Sbjct: 281 LLQVDPNNRSTAAKALNHPWIKMSPL 306 >3WNV-A nrPDB Length = 330 Score = 28.2 bits (61), Expect = 5.4, Method: Composition-based stats. Identities = 25/163 (15%), Positives = 55/163 (33%), Gaps = 17/163 (10%) Query: 204 AAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEEL-----------RRPEMKNFFK 252 A A G+ I R++ +L D K + + ++ + ++ R + Sbjct: 173 ARAFGMNIIYHNRNKLP-PELEDGAKYVSFDELLAQSDVFSLNLALNASTRHIIGEKELA 231 Query: 253 DMPQPRLALNCVGGKSST-ELLRQLARGGTMVTYGGMAKQPVVASVSLLIFKDLKLRGFW 311 M + +N G + L + G + + G + V + + + Sbjct: 232 KMKDGVVIVNTARGALIDEKALVRALESGKVASVG-LDVYENEPQVEPGLLNNPR---AM 287 Query: 312 LSQWKKDHSPDQFKELILTLCDLIRRGQLTAPACSQVPLQDYQ 354 L + + KE+ L + + +R +QVP Q + Sbjct: 288 LLPHIGTMTYETQKEMELLVLNNLRSAIEKGELLTQVPEQKKR 330 >4EUF-A nrPDB Length = 418 Score = 28.2 bits (61), Expect = 5.7, Method: Composition-based stats. Identities = 12/93 (12%), Positives = 34/93 (36%), Gaps = 7/93 (7%) Query: 185 DSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRR 244 V+ ++SG G +I+ A G + + + R+ + G + I +E + Sbjct: 61 KKVLIVGASSGFGL-ATRISVAFGGPEAHTIGVSYETGATDRRIGTAGWYNNIFFKEFAK 119 Query: 245 PEMKNFFKDMPQPRLALNCVGGKSSTELLRQLA 277 K + + ++ ++++ + Sbjct: 120 ------KKGLVAKNFIEDAFSNETKDKVIKYIK 146 >1F14-A nrPDB Length = 310 Score = 28.2 bits (61), Expect = 5.7, Method: Composition-based stats. Identities = 24/120 (20%), Positives = 38/120 (31%), Gaps = 19/120 (15%) Query: 185 DSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRR 244 V +G + Q+AAA G + V + + K + EE LR+ Sbjct: 16 KHVTVIGG-GLMGAGIAQVAAATGHTVVLVDQTEDILAKSKKGI----------EESLRK 64 Query: 245 PEMKNFFKDMPQPRLALNCVGGKSSTELLRQLARGGTMVTYGGMAKQPVVASVSLLIFKD 304 K F ++ CV + L +A + V A V L K+ Sbjct: 65 VAKKKFAENPKAGD---ECV-----EKTLSTIATSTDAASVVHSTDLVVEAIVENLKVKN 116 >2VHY-A nrPDB Length = 377 Score = 28.2 bits (61), Expect = 5.9, Method: Composition-based stats. Identities = 26/157 (16%), Positives = 46/157 (29%), Gaps = 27/157 (17%) Query: 152 VPSDIPLQSAATLGVNPCTAYRMLMDFEQ----------LQPGDSVIQNASNSGVGQAVI 201 +P P+ A AY ++ ++P D V+ G Sbjct: 127 LPLLAPMSEVAGRLAAQVGAYHLMRTQGGRGVLMGGVPGVEPADVVVI--GAGTAGYNAA 184 Query: 202 QIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFFKDMPQPRLAL 261 +IA +G + + D+L+ L AE R + + L + Sbjct: 185 RIANGMGATVTVLDIN-------IDKLRQLDAEFC-GRIHTRYSSAYELEGAVKRADLVI 236 Query: 262 NCV---GGKS----STELLRQLARGGTMVTYGGMAKQ 291 V G K+ S L+ + G +V Sbjct: 237 GAVLVPGAKAPKLVSNSLVAHMKPGAVLVDIAIDQGG 273 >3V8B-A nrPDB Length = 283 Score = 28.2 bits (61), Expect = 6.0, Method: Composition-based stats. Identities = 17/102 (16%), Positives = 40/102 (39%), Gaps = 5/102 (4%) Query: 182 QPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEE 241 QP + + SG+G+A AA G+ + R R ++++++D + G + + E + Sbjct: 26 QPSPVALITGAGSGIGRATALALAADGVTVGALGRTRTEVEEVADEIVGAGGQAIALEAD 85 Query: 242 LR-----RPEMKNFFKDMPQPRLALNCVGGKSSTELLRQLAR 278 + R +++ + + G + L Sbjct: 86 VSDELQMRNAVRDLVLKFGHLDIVVANAGINGVWAPIDDLKP 127 >4K6F-A nrPDB Length = 255 Score = 28.2 bits (61), Expect = 6.1, Method: Composition-based stats. Identities = 12/98 (12%), Positives = 33/98 (33%), Gaps = 8/98 (8%) Query: 188 IQNASNSGVGQAVIQIAAALGLRTINVVRDRPD-----IQKLSDRLKSLGAEHV-ITEEE 241 + G+G+AV G R + + ++ + A V + + + Sbjct: 15 VVTGGMGGLGEAVSIRLNDAGHRVVVTYSPNNTGADRWLTEMHAAGREFHAYPVDVADHD 74 Query: 242 LRRPEMKNFFKDMPQPRLALNCVG--GKSSTELLRQLA 277 + ++ +D+ + +N G + L ++ Sbjct: 75 SCQQCIEKIVRDVGPVDILVNNAGITRDMTLRKLDKVN 112 >6DEB-A nrPDB Length = 285 Score = 28.2 bits (61), Expect = 6.7, Method: Composition-based stats. Identities = 14/73 (19%), Positives = 27/73 (36%), Gaps = 3/73 (4%) Query: 160 SAATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQ-AVIQIAAALGLRTINVVRDR 218 + L P ++L +E G + +++ VG+ + A G T++V + Sbjct: 136 ESGFLPCTPLGVMKLLKAYEIDLEGKDAVIIGASNIVGRPMATMLLNA-GA-TVSVCHIK 193 Query: 219 PDIQKLSDRLKSL 231 L R L Sbjct: 194 TKDLSLYTRQADL 206 >1UZM-A nrPDB Length = 247 Score = 28.2 bits (61), Expect = 6.7, Method: Composition-based stats. Identities = 16/80 (20%), Positives = 27/80 (33%), Gaps = 6/80 (7%) Query: 186 SVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRP 245 SV+ N G+G A+ Q AA G + V K G E +T+ + Sbjct: 17 SVLVTGGNRGIGLAIAQRLAADG-HKVAVTHRGSGAPK-----GLFGVEVDVTDSDAVDR 70 Query: 246 EMKNFFKDMPQPRLALNCVG 265 + + ++ G Sbjct: 71 AFTAVEEHQGPVEVLVSNAG 90 >4DFE-A nrPDB Length = 333 Score = 28.2 bits (61), Expect = 6.7, Method: Composition-based stats. Identities = 16/74 (21%), Positives = 30/74 (40%), Gaps = 9/74 (12%) Query: 126 DWVIPANAGL----GTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQL 181 DW+IP A + T R + E ++ V SAA++ + A + ++ Sbjct: 255 DWLIPHQANIRIMQSTCRKLGLPQERMIVTVGEH-GNTSAASIPLALDVA----VRDGRI 309 Query: 182 QPGDSVIQNASNSG 195 + G +V+ G Sbjct: 310 KRGQNVLIEGVGGG 323 >4P80-A nrPDB Length = 180 Score = 27.8 bits (60), Expect = 7.1, Method: Composition-based stats. Identities = 11/53 (20%), Positives = 21/53 (39%), Gaps = 3/53 (5%) Query: 232 GAEHVITEEELRRPEMKNFFKDMPQPRLALNC---VGGKSSTELLRQLARGGT 281 GA+ + + + + + R A++ VG SS +L + RG Sbjct: 89 GADIPVDITDQKVILVDDVLYTGRTVRAAMDALVDVGRPSSIQLAVLVDRGHR 141 >4RZI-B nrPDB Length = 240 Score = 27.8 bits (60), Expect = 7.4, Method: Composition-based stats. Identities = 11/83 (13%), Positives = 27/83 (32%), Gaps = 5/83 (6%) Query: 183 PGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEEL 242 ++ N G+G A++++ +G + D+ ++LG +T+ E Sbjct: 7 EDKVIVVTGGNRGIGAAIVKLLQEMGAKVAFT-----DLATDGGNTEALGVVANVTDLES 61 Query: 243 RRPEMKNFFKDMPQPRLALNCVG 265 + + G Sbjct: 62 MTAAAAEITDKLGPVYGVVANAG 84 >2O23-A nrPDB Length = 265 Score = 27.8 bits (60), Expect = 7.7, Method: Composition-based stats. Identities = 14/105 (13%), Positives = 33/105 (31%), Gaps = 8/105 (7%) Query: 173 RMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLG 232 + + G + SG+G A + G + + + + K LG Sbjct: 1 GHMAAACRSVKGLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGE---AQAKKLG 57 Query: 233 AEHVITEEELRRPEMKNFFKDMPQP-----RLALNCVGGKSSTEL 272 V ++ + + + +A+NC G +++ Sbjct: 58 NNCVFAPADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVASKT 102 >3FCA-A nrPDB Length = 291 Score = 27.8 bits (60), Expect = 7.9, Method: Composition-based stats. Identities = 20/66 (30%), Positives = 31/66 (46%), Gaps = 4/66 (6%) Query: 177 DFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHV 236 L+ G I ++ +G A+ I A G R I + + +++ LK LGAE V Sbjct: 48 KRGLLKNG---IVEPTSGNMGIAIAMIGAKRGHRVILTMPETMSVERRK-VLKMLGAELV 103 Query: 237 ITEEEL 242 +T EL Sbjct: 104 LTPGEL 109 >3DC2-A nrPDB Length = 529 Score = 27.4 bits (59), Expect = 9.2, Method: Composition-based stats. Identities = 20/117 (17%), Positives = 34/117 (29%), Gaps = 12/117 (10%) Query: 184 GDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEEL- 242 G +V +GQ V Q AA G + + ++ L + ++ + Sbjct: 142 GKTVGVVG-LGRIGQLVAQRIAAFGAYVVAYDPYVSPARAAQLGIELLSLDDLLARADFI 200 Query: 243 -----RRPEM-----KNFFKDMPQPRLALNCVGGKSSTELLRQLARGGTMVTYGGMA 289 + PE K + +N G E A G V G+ Sbjct: 201 SVHLPKTPETAGLIDKEALAKTKPGVIIVNAARGGLVDEAALADAITGGHVRAAGLD 257 >1DIH-A nrPDB Length = 273 Score = 27.4 bits (59), Expect = 9.9, Method: Composition-based stats. Identities = 17/105 (16%), Positives = 33/105 (31%), Gaps = 7/105 (6%) Query: 186 SVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSL-GAEHVITEEELRR 244 V + +G+ +IQ A AL + +R L L GA + Sbjct: 7 RVAIAGAGGRMGRQLIQAALALEGVQLGAALEREGSSLLGSDAGELAGAGKTGVTVQSSL 66 Query: 245 PEMKNFFKDMPQPRLALNCVGGKSSTELLRQLARGGTMVTYGGMA 289 +K+ F + ++ + + L + G + G Sbjct: 67 DAVKDDF------DVFIDFTRPEGTLNHLAFCRQHGKGMVIGTTG 105 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.309 0.128 0.325 Lambda K H 0.267 0.0398 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 12,668,210 Number of Sequences: 36641 Number of extensions: 475232 Number of successful extensions: 2641 Number of sequences better than 10.0: 250 Number of HSP's better than 10.0 without gapping: 225 Number of HSP's successfully gapped in prelim test: 124 Number of HSP's that attempted gapping in prelim test: 1937 Number of HSP's gapped (non-prelim): 416 length of query: 373 length of database: 10,336,785 effective HSP length: 99 effective length of query: 274 effective length of database: 6,709,326 effective search space: 1838355324 effective search space used: 1838355324 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.2 bits) S2: 60 (27.8 bits)