BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q9BQA1 (342 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 5FA5-B nrPDB 692 0.0 4G56-B nrPDB 411 e-115 6EOJ-D nrPDB 75 3e-14 2YNP-A nrPDB 62 4e-10 3MKQ-A nrPDB 61 7e-10 6QX9-5O nrPDB 60 1e-09 1VYH-C nrPDB 60 2e-09 6N9G-C nrPDB 54 1e-07 3C9C-A nrPDB 53 2e-07 4BH6-A nrPDB 53 2e-07 5A31-R nrPDB 53 2e-07 5FL8-q nrPDB 52 3e-07 5Y1U-A nrPDB 51 7e-07 3CFV-B nrPDB 50 1e-06 5FVM-C nrPDB 50 1e-06 5NZU-C nrPDB 50 2e-06 4V6W-Ag nrPDB 49 2e-06 6G51-g nrPDB 49 3e-06 5WJC-A nrPDB 49 4e-06 4L9O-A nrPDB 47 8e-06 2H9P-A nrPDB 47 8e-06 5M25-A nrPDB 47 1e-05 3DM0-A nrPDB 45 3e-05 5WYK-BB nrPDB 45 4e-05 4LG8-A nrPDB 45 5e-05 3JAP-g nrPDB 45 6e-05 6J6H-n nrPDB 45 6e-05 6EMK-B nrPDB 44 8e-05 5Z56-q nrPDB 44 8e-05 4XYI-A nrPDB 44 8e-05 3JB9-g nrPDB 44 9e-05 5K1B-B nrPDB 44 1e-04 3BG0-A nrPDB 44 1e-04 6QDV-o nrPDB 44 1e-04 5YZG-W nrPDB 44 1e-04 6HQA-B nrPDB 43 2e-04 5WYJ-BE nrPDB 42 4e-04 5XYI-g nrPDB 42 5e-04 6ID0-T nrPDB 42 5e-04 4V8M-A7 nrPDB 42 5e-04 5OPT-p nrPDB 41 7e-04 5WLC-LU nrPDB 41 7e-04 5WLC-LN nrPDB 41 8e-04 4BZK-B nrPDB 41 9e-04 3JRP-A nrPDB 41 9e-04 5I2T-A nrPDB 40 0.001 5MZH-A nrPDB 40 0.001 5WLC-LO nrPDB 40 0.001 6E29-D nrPDB 40 0.001 3JB9-L nrPDB 40 0.001 4BTS-AR nrPDB 40 0.001 6QX9-4B nrPDB 40 0.001 6MZM-G nrPDB 40 0.002 5NNZ-B nrPDB 40 0.002 5L9T-R nrPDB 40 0.002 6F3T-A nrPDB 40 0.002 5Y88-O nrPDB 39 0.002 5OQL-L nrPDB 39 0.002 3JRO-A nrPDB 39 0.002 6HHQ-h nrPDB 39 0.003 6Q8F-A nrPDB 39 0.004 2PM9-A nrPDB 39 0.004 3W15-A nrPDB 38 0.006 4A11-B nrPDB 38 0.006 5OQL-d nrPDB 38 0.008 4J0W-A nrPDB 37 0.009 5A9Q-2 nrPDB 37 0.013 4V7E-Bg nrPDB 37 0.017 5A9Q-7 nrPDB 35 0.037 5CXC-A nrPDB 35 0.046 5A9Q-0 nrPDB 35 0.060 4AEZ-A nrPDB 34 0.083 3F3P-A nrPDB 34 0.086 5OQL-J nrPDB 34 0.10 6ELZ-p nrPDB 34 0.10 3FM0-A nrPDB 33 0.13 5K0Y-T nrPDB 33 0.15 3JB9-S nrPDB 33 0.16 6GMH-W nrPDB 33 0.16 5MWJ-A nrPDB 33 0.17 3JZG-A nrPDB 33 0.17 4PSX-B nrPDB 33 0.19 5UZ7-B nrPDB 33 0.22 2AQ5-A nrPDB 32 0.28 4E5Z-B nrPDB 32 0.37 3ACP-A nrPDB 32 0.57 4XFV-A nrPDB 31 0.61 5G04-R nrPDB 31 0.64 6BX3-A nrPDB 31 0.82 4GGA-A nrPDB 31 1.0 5LCW-Q nrPDB 30 1.1 5K1H-B nrPDB 30 1.1 4N14-A nrPDB 30 1.2 3ODT-A nrPDB 30 1.6 3EI3-B nrPDB 30 1.7 3DW8-B nrPDB 30 1.7 5OQL-X nrPDB 29 2.9 5BJS-A nrPDB 29 2.9 5WYJ-BC nrPDB 29 3.0 2JIP-A nrPDB 29 3.2 5GAN-H nrPDB 29 3.7 1NR0-A nrPDB 29 3.7 5K19-A nrPDB 28 4.9 6B1B-A nrPDB 28 5.7 6GB2-BC nrPDB 28 5.9 4YCZ-A nrPDB 28 7.3 1A8S-A nrPDB 28 7.4 4H0P-A nrPDB 28 7.6 >5FA5-B nrPDB Length = 367 Score = 692 bits (1785), Expect = 0.0, Method: Compositional matrix adjust. Identities = 341/342 (99%), Positives = 342/342 (100%) Query: 1 MRKETPPPLVPPAAREWNLPPNAPACMERQLEAARYRSDGALLLGASSLSGRCWAGSLWL 60 +RKETPPPLVPPAAREWNLPPNAPACMERQLEAARYRSDGALLLGASSLSGRCWAGSLWL Sbjct: 26 LRKETPPPLVPPAAREWNLPPNAPACMERQLEAARYRSDGALLLGASSLSGRCWAGSLWL 85 Query: 61 FKDPCAAPNEGFCSAGVQTEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFC 120 FKDPCAAPNEGFCSAGVQTEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFC Sbjct: 86 FKDPCAAPNEGFCSAGVQTEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFC 145 Query: 121 KYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKD 180 KYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKD Sbjct: 146 KYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKD 205 Query: 181 SVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLV 240 SVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLV Sbjct: 206 SVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLV 265 Query: 241 DTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHRDFV 300 DTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHRDFV Sbjct: 266 DTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHRDFV 325 Query: 301 RDATWSPLNHSLLTTVGWDHQVVHHVVPTEPLPAPGPASVTE 342 RDATWSPLNHSLLTTVGWDHQVVHHVVPTEPLPAPGPASVTE Sbjct: 326 RDATWSPLNHSLLTTVGWDHQVVHHVVPTEPLPAPGPASVTE 367 >4G56-B nrPDB Length = 357 Score = 411 bits (1057), Expect = e-115, Method: Compositional matrix adjust. Identities = 201/314 (64%), Positives = 243/314 (77%) Query: 17 WNLPPNAPACMERQLEAARYRSDGALLLGASSLSGRCWAGSLWLFKDPCAAPNEGFCSAG 76 W P APACME Q+ A RYR DGALLL ASSLS R W GS+W+FKDP APNE C+AG Sbjct: 31 WGRPVTAPACMEVQIGAVRYRRDGALLLAASSLSSRTWGGSIWVFKDPEGAPNESLCTAG 90 Query: 77 VQTEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSS 136 VQTEAGV D+ WV E+GILVASDSGAVELWE+ E E+L+V+KF KYEHDDIV T+SV S Sbjct: 91 VQTEAGVTDVAWVSEKGILVASDSGAVELWEILEKESLLVNKFAKYEHDDIVKTLSVFSD 150 Query: 137 GTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWD 196 GTQAVSG KD +KVWDL+Q+ VL SY AH+++V CVAA P KD++FLSC ED RILLWD Sbjct: 151 GTQAVSGGKDFSVKVWDLSQKAVLKSYNAHSSEVNCVAACPGKDTIFLSCGEDGRILLWD 210 Query: 197 TRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQ 256 TR PKPA++I A +PTS+ WHP++ + F GDE G VSLV+ K+ +SAVHSQ Sbjct: 211 TRKPKPATRIDFCASDTIPTSVTWHPEKDDTFACGDETGNVSLVNIKNPDSAQTSAVHSQ 270 Query: 257 CVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHRDFVRDATWSPLNHSLLTTV 316 +TGL +S HS PFLAS+SEDC++AVLD+ SE+FR +HRDFV WSPL+HS TTV Sbjct: 271 NITGLAYSYHSSPFLASISEDCTVAVLDADFSEVFRDLSHRDFVTGVAWSPLDHSKFTTV 330 Query: 317 GWDHQVVHHVVPTE 330 GWDH+V+HH +P+E Sbjct: 331 GWDHKVLHHHLPSE 344 >6EOJ-D nrPDB Length = 470 Score = 75.5 bits (184), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 65/242 (26%), Positives = 105/242 (43%), Gaps = 12/242 (4%) Query: 86 LTWVGE-RGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGS 144 + W E R ++VA+ SG LW N + + HD V+T+ +SG Sbjct: 99 IQWTPEGRRLVVATYSGEFSLW----NASSFTFETLMQAHDSAVTTMKYSHDSDWMISGD 154 Query: 145 KDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPAS 204 D IK+W +V AH + +A S + DS F++CS+DN + +W+ K Sbjct: 155 ADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSN-DSKFVTCSDDNILKIWNFSNGKQER 213 Query: 205 QIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFS 264 + S + S WHP+ + ++ V L D +S +C+ S V F Sbjct: 214 VL--SGHHWDVKSCDWHPEMG-LIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQ 270 Query: 265 PHSVPFLASLSEDCSLAVLD--SSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQV 322 P L ++S+D S V D S+ EL + D++ W P+N S+ T +D + Sbjct: 271 PTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMT-LEWHPINESMFTLACYDGSL 329 Query: 323 VH 324 H Sbjct: 330 KH 331 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 29/127 (22%), Positives = 53/127 (41%), Gaps = 5/127 (3%) Query: 142 SGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPK 201 S SKD +K+WD +SS V P K ++ ++ S+D ++D R Sbjct: 236 SASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRY-- 293 Query: 202 PASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVS---LVDTKSTSCVLSSAVHSQCV 258 ++ C +L WHP +F +G++ L+ + + H +C+ Sbjct: 294 SMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCI 353 Query: 259 TGLVFSP 265 T L ++P Sbjct: 354 TSLSYNP 360 >2YNP-A nrPDB Length = 604 Score = 62.0 bits (149), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 51/204 (25%), Positives = 95/204 (46%), Gaps = 26/204 (12%) Query: 94 ILVASDSGAVELWELDENETLIVSKFCKYE-HDDIVSTVSVLSSGTQAVSGSKDICIKVW 152 I+V SD + ++ + E K +E H D + +++V + +SGS D+ +K+W Sbjct: 70 IIVGSDDFRIRVFNYNTGE-----KVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLW 124 Query: 153 DLAQQVVL-SSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAP 211 + L ++ H V CVA +P S F S D + +W +G S P Sbjct: 125 NWENNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVW---------SLGQSTP 175 Query: 212 GYLPTS--------LAWHPQQSEVFVF-GDENGTVSLVDTKSTSCVLSSAVHSQCVTGLV 262 + T+ + ++P + ++ ++ T+ + D ++ SCV + H V+ V Sbjct: 176 NFTLTTGQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAV 235 Query: 263 FSPHSVPFLASLSEDCSLAVLDSS 286 F P ++P + S SED +L + +SS Sbjct: 236 FHP-TLPIIISGSEDGTLKIWNSS 258 >3MKQ-A nrPDB Length = 814 Score = 61.2 bits (147), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 51/204 (25%), Positives = 95/204 (46%), Gaps = 26/204 (12%) Query: 94 ILVASDSGAVELWELDENETLIVSKFCKYE-HDDIVSTVSVLSSGTQAVSGSKDICIKVW 152 I+V SD + ++ + E K +E H D + +++V + +SGS D+ +K+W Sbjct: 70 IIVGSDDFRIRVFNYNTGE-----KVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLW 124 Query: 153 DLAQQVVL-SSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAP 211 + L ++ H V CVA +P S F S D + +W +G S P Sbjct: 125 NWENNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVW---------SLGQSTP 175 Query: 212 GYLPTS--------LAWHPQQSEVFVF-GDENGTVSLVDTKSTSCVLSSAVHSQCVTGLV 262 + T+ + ++P + ++ ++ T+ + D ++ SCV + H V+ V Sbjct: 176 NFTLTTGQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAV 235 Query: 263 FSPHSVPFLASLSEDCSLAVLDSS 286 F P ++P + S SED +L + +SS Sbjct: 236 FHP-TLPIIISGSEDGTLKIWNSS 258 >6QX9-5O nrPDB Length = 357 Score = 60.1 bits (144), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 52/199 (26%), Positives = 86/199 (43%), Gaps = 14/199 (7%) Query: 90 GERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICI 149 G + + SD G V+LW++ + + +++ V V+ + Q +SG D I Sbjct: 163 GPQLVCTGSDDGTVKLWDIRKKAAIQT-----FQNTYQVLAVTFNDTSDQIISGGIDNDI 217 Query: 150 KVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCS 209 KVWDL Q + + R HA VT ++ S + S LS + DN + +WD R P + Sbjct: 218 KVWDLRQNKLTYTMRGHADSVTGLSLSS-EGSYLLSNAMDNTVRVWDVRPFAPKERCVKI 276 Query: 210 APGYLPT------SLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVF 263 G + +W P S++ G + V + DT S + H+ + + F Sbjct: 277 FQGNVHNFEKNLLRCSWSPDGSKI-AAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAF 335 Query: 264 SPHSVPFLASLSEDCSLAV 282 P P + S S D L + Sbjct: 336 HPDE-PIIISASSDKRLYM 353 Score = 37.4 bits (85), Expect = 0.009, Method: Compositional matrix adjust. Identities = 41/194 (21%), Positives = 74/194 (38%), Gaps = 16/194 (8%) Query: 124 HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVF 183 H V + + G+ S S D + VWD + + H + V + + Sbjct: 108 HSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLV 167 Query: 184 LSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTK 243 + S+D + LWD R K A Q + L + S+ + G + + + D + Sbjct: 168 CTGSDDGTVKLWDIR-KKAAIQTFQNTYQVLAVTFN---DTSDQIISGGIDNDIKVWDLR 223 Query: 244 STSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLD-------SSLSELFRSQAH 296 + H+ VTGL S +L S + D ++ V D ++F+ H Sbjct: 224 QNKLTYTMRGHADSVTGLSLSSEG-SYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVH 282 Query: 297 ---RDFVRDATWSP 307 ++ +R +WSP Sbjct: 283 NFEKNLLR-CSWSP 295 >1VYH-C nrPDB Length = 410 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 53/231 (22%), Positives = 100/231 (43%), Gaps = 32/231 (13%) Query: 93 GILVASDSG--AVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIK 150 G L+AS S ++LW+ E + + HD VS+VS++ +G VS S+D IK Sbjct: 162 GKLLASCSADMTIKLWDFQGFECIRTM----HGHDHNVSSVSIMPNGDHIVSASRDKTIK 217 Query: 151 VWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFL-SCSEDNRILLWDTRCPKPASQIGCS 209 +W++ + ++ H V V P++D + SCS D + +W + +++ Sbjct: 218 MWEVQTGYCVKTFTGHREWVRMV--RPNQDGTLIASCSNDQTVRVWVVATKECKAEL--R 273 Query: 210 APGYLPTSLAWHPQQSE-------------------VFVFGDENGTVSLVDTKSTSCVLS 250 ++ ++W P+ S + G + T+ + D + C+++ Sbjct: 274 EHRHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMT 333 Query: 251 SAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRS-QAHRDFV 300 H V G++F F+ S ++D +L V D ++ AH FV Sbjct: 334 LVGHDNWVRGVLFHSGG-KFILSCADDKTLRVWDYKNKRCMKTLNAHEHFV 383 Score = 41.6 bits (96), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 27/105 (25%), Positives = 49/105 (46%), Gaps = 5/105 (4%) Query: 94 ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWD 153 ++ AS+ +++W+ + + K H D V +S SG S S D+ IK+WD Sbjct: 123 MVSASEDATIKVWDYETGDFERTLK----GHTDSVQDISFDHSGKLLASCSADMTIKLWD 178 Query: 154 LAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTR 198 + + H V+ V+ P+ D + +S S D I +W+ + Sbjct: 179 FQGFECIRTMHGHDHNVSSVSIMPNGDHI-VSASRDKTIKMWEVQ 222 Score = 37.4 bits (85), Expect = 0.010, Method: Compositional matrix adjust. Identities = 40/168 (23%), Positives = 70/168 (41%), Gaps = 6/168 (3%) Query: 141 VSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCP 200 VS S+D IKVWD + + H V ++ H + SCS D I LWD + Sbjct: 124 VSASEDATIKVWDYETGDFERTLKGHTDSVQDISFD-HSGKLLASCSADMTIKLWDFQGF 182 Query: 201 KPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTG 260 + + + +S++ P + V + T+ + + ++ CV + H + V Sbjct: 183 ECIRTM--HGHDHNVSSVSIMPNGDHI-VSASRDKTIKMWEVQTGYCVKTFTGHREWVR- 238 Query: 261 LVFSPHSVPFLASLSEDCSLAVLDSSLSELFRS-QAHRDFVRDATWSP 307 +V +AS S D ++ V + E + HR V +W+P Sbjct: 239 MVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHRHVVECISWAP 286 Score = 31.6 bits (70), Expect = 0.49, Method: Compositional matrix adjust. Identities = 25/106 (23%), Positives = 48/106 (45%), Gaps = 7/106 (6%) Query: 94 ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWD 153 +L S +++W++ L+ HD+ V V S G +S + D ++VWD Sbjct: 311 LLSGSRDKTIKMWDVSTGMCLMTL----VGHDNWVRGVLFHSGGKFILSCADDKTLRVWD 366 Query: 154 LAQQVVLSSYRAHAAQVTCVAASPHKDSVF-LSCSEDNRILLWDTR 198 + + + AH VT + HK + + ++ S D + +W+ R Sbjct: 367 YKNKRCMKTLNAHEHFVTSL--DFHKTAPYVVTGSVDQTVKVWECR 410 >6N9G-C nrPDB Length = 353 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 55/226 (24%), Positives = 97/226 (42%), Gaps = 23/226 (10%) Query: 108 LDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHA 167 D+NE + K H + +S S +S Q ++ S D +WD+ +L S+ H Sbjct: 136 FDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHG 195 Query: 168 AQVTCVAASPHK-DSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSE 226 A V C+ +P + + F+S D + ++WD R + S+ ++P + Sbjct: 196 ADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDV--NSVRYYP-SGD 252 Query: 227 VFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPF------LASLSEDCSL 280 F G ++ T L D ++ V A++S+ ++F SV F L + D ++ Sbjct: 253 AFASGSDDATCRLYDLRADREV---AIYSK--ESIIFGASSVDFSLSGRLLFAGYNDYTI 307 Query: 281 AVLD----SSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQV 322 V D S +S LF H + V SP + + + WDH + Sbjct: 308 NVWDVLKGSRVSILF---GHENRVSTLRVSP-DGTAFCSGSWDHTL 349 >3C9C-A nrPDB Length = 432 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 44/169 (26%), Positives = 81/169 (47%), Gaps = 10/169 (5%) Query: 164 RAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRC-PKPASQIGC----SAPGYLPTSL 218 R H + ++ +P+ + LS S+D+ I LWD PK I + + + Sbjct: 180 RGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDV 239 Query: 219 AWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAV---HSQCVTGLVFSPHSVPFLASLS 275 AWH +F ++ + + DT++ + S H+ V L F+P+S LA+ S Sbjct: 240 AWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGS 299 Query: 276 EDCSLAVLD-SSLS-ELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQV 322 D ++A+ D +L +L ++H+D + WSP N ++L + G D ++ Sbjct: 300 ADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRL 348 Score = 50.8 bits (120), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 50/193 (25%), Positives = 83/193 (43%), Gaps = 28/193 (14%) Query: 141 VSGSKDICIKVWDL----AQQVVLSS---YRAHAAQVTCVAASPHKDSVFLSCSEDNRIL 193 +S S D I +WD+ + V+ + + H A V VA +S+F S ++D +++ Sbjct: 200 LSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLM 259 Query: 194 LWDTR---CPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLS 250 +WDTR KP+ + L+++P + G + TV+L D ++ L Sbjct: 260 IWDTRNNNTSKPSHTVDAHTAEV--NCLSFNPYSEFILATGSADKTVALWDLRNLKLKLH 317 Query: 251 S-AVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLD-SSLSE--------------LFRSQ 294 S H + + +SPH+ LAS D L V D S + E LF Sbjct: 318 SFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHG 377 Query: 295 AHRDFVRDATWSP 307 H + D +W+P Sbjct: 378 GHTAKISDFSWNP 390 Score = 35.8 bits (81), Expect = 0.026, Method: Compositional matrix adjust. Identities = 29/115 (25%), Positives = 53/115 (46%), Gaps = 7/115 (6%) Query: 94 ILVASDSGAVELWELD---ENETLIVSKFCKYEHDDIVSTVS-VLSSGTQAVSGSKDICI 149 +L ASD + LW+++ + +I +K H +V V+ L + S + D + Sbjct: 199 LLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKL 258 Query: 150 KVWDLAQQVVLS---SYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPK 201 +WD + AH A+V C++ +P+ + + + S D + LWD R K Sbjct: 259 MIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLK 313 >4BH6-A nrPDB Length = 308 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 41/166 (24%), Positives = 80/166 (48%), Gaps = 7/166 (4%) Query: 108 LDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHA 167 L +N T V C E++ +++S + +G+ G + ++++D+ ++ + + H Sbjct: 47 LTDNNTGDVVHLCDTENE--YTSLSWIGAGSHLAVGQANGLVEIYDVMKRKCIRTLSGHI 104 Query: 168 AQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEV 227 +V C++ + H V S S D+RIL D R P P + S + L W+ +++ Sbjct: 105 DRVACLSWNNH---VLTSGSRDHRILHRDVRMPDPFFETIESHTQEV-CGLKWNVADNKL 160 Query: 228 FVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLAS 273 G++N V + + S S +L+ H V + +SPH LA+ Sbjct: 161 ASGGNDN-VVHVYEGTSKSPILTFDEHKAAVKAMAWSPHKRGVLAT 205 Score = 32.0 bits (71), Expect = 0.37, Method: Compositional matrix adjust. Identities = 21/92 (22%), Positives = 39/92 (42%), Gaps = 5/92 (5%) Query: 138 TQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLS--CSEDNRILLW 195 + SG D + V++ + + ++ H A V +A SPHK V + + D R+ +W Sbjct: 158 NKLASGGNDNVVHVYEGTSKSPILTFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIW 217 Query: 196 DTRCPKPASQIGCSAPGYLPTSLAWHPQQSEV 227 + S I G ++ W +E+ Sbjct: 218 NVNTSIKMSDID---SGSQICNMVWSKNTNEL 246 >5A31-R nrPDB Length = 386 Score = 52.8 bits (125), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 41/166 (24%), Positives = 80/166 (48%), Gaps = 7/166 (4%) Query: 108 LDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHA 167 L +N T V C E++ +++S + +G+ G + ++++D+ ++ + + H Sbjct: 116 LTDNNTGDVVHLCDTENE--YTSLSWIGAGSHLAVGQANGLVEIYDVMKRKCIRTLSGHI 173 Query: 168 AQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEV 227 +V C++ + H V S S D+RIL D R P P + S + L W+ +++ Sbjct: 174 DRVACLSWNNH---VLTSGSRDHRILHRDVRMPDPFFETIESHTQEV-CGLKWNVADNKL 229 Query: 228 FVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLAS 273 G++N V + + S S +L+ H V + +SPH LA+ Sbjct: 230 ASGGNDN-VVHVYEGTSKSPILTFDEHKAAVKAMAWSPHKRGVLAT 274 Score = 32.3 bits (72), Expect = 0.33, Method: Compositional matrix adjust. Identities = 21/92 (22%), Positives = 39/92 (42%), Gaps = 5/92 (5%) Query: 138 TQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLS--CSEDNRILLW 195 + SG D + V++ + + ++ H A V +A SPHK V + + D R+ +W Sbjct: 227 NKLASGGNDNVVHVYEGTSKSPILTFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIW 286 Query: 196 DTRCPKPASQIGCSAPGYLPTSLAWHPQQSEV 227 + S I G ++ W +E+ Sbjct: 287 NVNTSIKMSDID---SGSQICNMVWSKNTNEL 315 >5FL8-q nrPDB Length = 515 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 46/173 (26%), Positives = 78/173 (45%), Gaps = 18/173 (10%) Query: 136 SGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLW 195 + ++ V+G+ D ++WD Q + + + H V CV+ SP + V + S DN I LW Sbjct: 155 TSSRMVTGAGDNTARIWDCDTQTPMHTLKGHYNWVLCVSWSPDGE-VIATGSMDNTIRLW 213 Query: 196 DTRCPKPASQIGCSAPGYLP--TSLAWH------PQQSEVFVFGDENGTVSLVDTKSTSC 247 D PK +G + G+ TSL+W P ++GT+ + DT S C Sbjct: 214 D---PKSGQCLGDALRGHSKWITSLSWEPIHLVKPGSKPRLASSSKDGTIKIWDTVSRVC 270 Query: 248 VLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLS----ELFRSQAH 296 + + H+ V+ + + L S S D ++ V D + + +S AH Sbjct: 271 QYTMSGHTNSVSCVKWGGQG--LLYSGSHDRTVRVWDINSQGRCINILKSHAH 321 Score = 47.8 bits (112), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 39/133 (29%), Positives = 61/133 (45%), Gaps = 12/133 (9%) Query: 161 SSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAW 220 S+ H + + C A +PH S ++ + DN +WD P + L ++W Sbjct: 137 SAIAGHGSTILCSAFAPHTSSRMVTGAGDNTARIWDCDTQTPMHTLKGHYNWVL--CVSW 194 Query: 221 HPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAV--HSQCVTGL------VFSPHSVPFLA 272 P EV G + T+ L D KS C L A+ HS+ +T L + P S P LA Sbjct: 195 SP-DGEVIATGSMDNTIRLWDPKSGQC-LGDALRGHSKWITSLSWEPIHLVKPGSKPRLA 252 Query: 273 SLSEDCSLAVLDS 285 S S+D ++ + D+ Sbjct: 253 SSSKDGTIKIWDT 265 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 35/111 (31%), Positives = 52/111 (46%), Gaps = 4/111 (3%) Query: 91 ERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIK 150 E ++ ASD + LW ++ I H +V+ V+ G VS S D IK Sbjct: 371 EEMMVTASDDYTMFLWNPLKSTKPIARMTG---HQKLVNHVAFSPDGRYIVSASFDNSIK 427 Query: 151 VWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPK 201 +WD +S++R H A V VA S + +SCS+D + +WD R K Sbjct: 428 LWDGRDGKFISTFRGHVASVYQVAWSSDC-RLLVSCSKDTTLKVWDVRTRK 477 Score = 30.0 bits (66), Expect = 1.3, Method: Compositional matrix adjust. Identities = 30/113 (26%), Positives = 48/113 (42%), Gaps = 12/113 (10%) Query: 92 RGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKV 151 R + A D+ A +W+ D + K H + V VS G +GS D I++ Sbjct: 158 RMVTGAGDNTA-RIWDCDTQTPMHTLK----GHYNWVLCVSWSPDGEVIATGSMDNTIRL 212 Query: 152 WD-LAQQVVLSSYRAHAAQVTCVA------ASPHKDSVFLSCSEDNRILLWDT 197 WD + Q + + R H+ +T ++ P S S+D I +WDT Sbjct: 213 WDPKSGQCLGDALRGHSKWITSLSWEPIHLVKPGSKPRLASSSKDGTIKIWDT 265 Score = 29.6 bits (65), Expect = 1.9, Method: Compositional matrix adjust. Identities = 31/104 (29%), Positives = 45/104 (43%), Gaps = 5/104 (4%) Query: 92 RGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKV 151 R I+ AS +++LW D + +S F H V V+ S VS SKD +KV Sbjct: 415 RYIVSASFDNSIKLW--DGRDGKFISTF--RGHVASVYQVAWSSDCRLLVSCSKDTTLKV 470 Query: 152 WDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLW 195 WD+ + + H +V V S V S +D + LW Sbjct: 471 WDVRTRKLSVDLPGHKDEVYTVDWSVDGKRV-CSGGKDKMVRLW 513 >5Y1U-A nrPDB Length = 456 Score = 51.2 bits (121), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 44/169 (26%), Positives = 82/169 (48%), Gaps = 10/169 (5%) Query: 164 RAHAAQVTCVAASPHKDSVFLSCSEDNRILLWD-TRCPKPASQIGCSA--PGY--LPTSL 218 R H + ++ +P+ LS S+D+ I LWD + PK + G+ + + Sbjct: 205 RGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDV 264 Query: 219 AWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSA---VHSQCVTGLVFSPHSVPFLASLS 275 +WH +F ++ + + DT+S + S H+ V L F+P+S LA+ S Sbjct: 265 SWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGS 324 Query: 276 EDCSLAVLD-SSLS-ELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQV 322 D ++A+ D +L +L ++H+D + WSP N ++L + G D ++ Sbjct: 325 ADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRL 373 Score = 49.3 bits (116), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 50/193 (25%), Positives = 84/193 (43%), Gaps = 28/193 (14%) Query: 141 VSGSKDICIKVWDLAQ-----QVVLSS--YRAHAAQVTCVAASPHKDSVFLSCSEDNRIL 193 +S S D I +WD++ +VV + + H A V V+ +S+F S ++D +++ Sbjct: 225 LSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLM 284 Query: 194 LWDTR---CPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLS 250 +WDTR KP+ + L+++P + G + TV+L D ++ L Sbjct: 285 IWDTRSNNTSKPSHSVDAHTAEV--NCLSFNPYSEFILATGSADKTVALWDLRNLKLKLH 342 Query: 251 S-AVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLD-SSLSE--------------LFRSQ 294 S H + + +SPH+ LAS D L V D S + E LF Sbjct: 343 SFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHG 402 Query: 295 AHRDFVRDATWSP 307 H + D +W+P Sbjct: 403 GHTAKISDFSWNP 415 Score = 41.6 bits (96), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 45/178 (25%), Positives = 74/178 (41%), Gaps = 24/178 (13%) Query: 36 YRSDGALLLGASSLSGRCWAGS------LWLFKDPCAAPNEGFCSAGVQTEAG----VAD 85 ++ +G L +LSG + S LW D A P EG G V D Sbjct: 207 HQKEGYGLSWNPNLSGHLLSASDDHTICLW---DISAVPKEGKVVDAKTIFTGHTAVVED 263 Query: 86 LTW--VGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQA--- 140 ++W + E +D + +W+ N T S D + V+ LS + Sbjct: 264 VSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSV----DAHTAEVNCLSFNPYSEFI 319 Query: 141 -VSGSKDICIKVWDLAQ-QVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWD 196 +GS D + +WDL ++ L S+ +H ++ V SPH +++ S D R+ +WD Sbjct: 320 LATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWD 377 Score = 35.4 bits (80), Expect = 0.036, Method: Compositional matrix adjust. Identities = 30/115 (26%), Positives = 52/115 (45%), Gaps = 7/115 (6%) Query: 94 ILVASDSGAVELWELD---ENETLIVSKFCKYEHDDIVSTVS-VLSSGTQAVSGSKDICI 149 +L ASD + LW++ + ++ +K H +V VS L + S + D + Sbjct: 224 LLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKL 283 Query: 150 KVWDLAQQVVLS---SYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPK 201 +WD S AH A+V C++ +P+ + + + S D + LWD R K Sbjct: 284 MIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLK 338 Score = 28.1 bits (61), Expect = 6.4, Method: Compositional matrix adjust. Identities = 28/116 (24%), Positives = 49/116 (42%), Gaps = 16/116 (13%) Query: 94 ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWD 153 + S V LW+L N L + F ++ D+I + T S D + VWD Sbjct: 320 LATGSADKTVALWDL-RNLKLKLHSFESHK-DEIFQVQWSPHNETILASSGTDRRLNVWD 377 Query: 154 LAQ--------------QVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLW 195 L++ +L + H A+++ + +P++ V S SEDN + +W Sbjct: 378 LSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW 433 >3CFV-B nrPDB Length = 414 Score = 50.1 bits (118), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 44/169 (26%), Positives = 82/169 (48%), Gaps = 10/169 (5%) Query: 164 RAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRC-PKPASQIGCSA--PGY--LPTSL 218 R H + ++ + + LS S+D+ + LWD PK + A G+ + + Sbjct: 176 RGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDV 235 Query: 219 AWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAV---HSQCVTGLVFSPHSVPFLASLS 275 AWH +F ++ + + DT+S + S + H+ V L F+P+S LA+ S Sbjct: 236 AWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGS 295 Query: 276 EDCSLAVLD-SSLS-ELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQV 322 D ++A+ D +L +L ++H+D + WSP N ++L + G D ++ Sbjct: 296 ADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRL 344 Score = 47.8 bits (112), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 48/193 (24%), Positives = 84/193 (43%), Gaps = 28/193 (14%) Query: 141 VSGSKDICIKVWDLAQ-----QVVLSS--YRAHAAQVTCVAASPHKDSVFLSCSEDNRIL 193 +S S D + +WD+ ++V + + H+A V VA +S+F S ++D +++ Sbjct: 196 LSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESLFGSVADDQKLM 255 Query: 194 LWDTR---CPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLS 250 +WDTR KP+ + L+++P + G + TV+L D ++ L Sbjct: 256 IWDTRSNTTSKPSHLVDAHTAEV--NCLSFNPYSEFILATGSADKTVALWDLRNLKLKLH 313 Query: 251 S-AVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLD-SSLSE--------------LFRSQ 294 + H + + +SPH+ LAS D L V D S + E LF Sbjct: 314 TFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHG 373 Query: 295 AHRDFVRDATWSP 307 H + D +W+P Sbjct: 374 GHTAKISDFSWNP 386 Score = 42.7 bits (99), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 45/178 (25%), Positives = 74/178 (41%), Gaps = 24/178 (13%) Query: 36 YRSDGALLLGASSLSGRCWAGS------LWLFKDPCAAPNEGFCSAGVQTEAG----VAD 85 ++ +G L S+LSG + S LW D A P EG G V D Sbjct: 178 HQKEGYGLSWNSNLSGHLLSASDDHTVCLW---DINAGPKEGKIVDAKAIFTGHSAVVED 234 Query: 86 LTW--VGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQA--- 140 + W + E +D + +W+ N T S D + V+ LS + Sbjct: 235 VAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLV----DAHTAEVNCLSFNPYSEFI 290 Query: 141 -VSGSKDICIKVWDLAQ-QVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWD 196 +GS D + +WDL ++ L ++ +H ++ V SPH +++ S D R+ +WD Sbjct: 291 LATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWD 348 Score = 35.4 bits (80), Expect = 0.038, Method: Compositional matrix adjust. Identities = 37/148 (25%), Positives = 61/148 (41%), Gaps = 11/148 (7%) Query: 63 DPCAAPNEGFCSAGVQTEAGVADLTWVGERG--ILVASDSGAVELWELD---ENETLIVS 117 DP N G Q E L+W +L ASD V LW+++ + ++ + Sbjct: 164 DPSGECNPDLRLRGHQKEG--YGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDA 221 Query: 118 KFCKYEHDDIVSTVS-VLSSGTQAVSGSKDICIKVWDLAQQVVLSSYR---AHAAQVTCV 173 K H +V V+ L + S + D + +WD AH A+V C+ Sbjct: 222 KAIFTGHSAVVEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCL 281 Query: 174 AASPHKDSVFLSCSEDNRILLWDTRCPK 201 + +P+ + + + S D + LWD R K Sbjct: 282 SFNPYSEFILATGSADKTVALWDLRNLK 309 Score = 28.1 bits (61), Expect = 6.1, Method: Compositional matrix adjust. Identities = 28/116 (24%), Positives = 49/116 (42%), Gaps = 16/116 (13%) Query: 94 ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWD 153 + S V LW+L N L + F ++ D+I + T S D + VWD Sbjct: 291 LATGSADKTVALWDL-RNLKLKLHTFESHK-DEIFQVHWSPHNETILASSGTDRRLNVWD 348 Query: 154 LAQ--------------QVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLW 195 L++ +L + H A+++ + +P++ V S SEDN + +W Sbjct: 349 LSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIW 404 >5FVM-C nrPDB Length = 303 Score = 50.1 bits (118), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 39/127 (30%), Positives = 61/127 (48%), Gaps = 5/127 (3%) Query: 71 GFCSAGVQ-TEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVS 129 G CS +Q ++ V L ++ L A+ V L+++ N VS F H V+ Sbjct: 22 GVCSRTIQHADSQVNRLEITSDKKYLAAAGHLHVRLYDIRSNNPNPVSSF--EGHKGNVT 79 Query: 130 TVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSED 189 +++ VS S+D IKVWD+ V +Y+ H A V VA P++ +SC +D Sbjct: 80 SIAFQQENRWMVSSSEDGTIKVWDVRSPSVQRNYK-HNAPVNEVAIHPNQGE-LISCDQD 137 Query: 190 NRILLWD 196 I +WD Sbjct: 138 GNIRIWD 144 >5NZU-C nrPDB Length = 905 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 47/210 (22%), Positives = 93/210 (44%), Gaps = 30/210 (14%) Query: 124 HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSS-YRAHAAQVTCVAASPHKDSV 182 H D + ++V + ++ S D+ IK+WD ++ S + H V + +P ++ Sbjct: 98 HSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQ 157 Query: 183 FLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQ-----------QSEVFVFG 231 F S S D I +W Q+G S+P + +L H + + G Sbjct: 158 FASASLDRTIKVW---------QLGSSSPNF---TLEGHEKGVNCIDYYSGGDKPYLISG 205 Query: 232 DENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELF 291 ++ V + D ++ +CV + H+Q V+ F P +P + + SED ++ + SS + Sbjct: 206 ADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHP-ELPIIITGSEDGTVRIWHSS---TY 261 Query: 292 RSQAHRDFVRDATW--SPLNHSLLTTVGWD 319 R ++ ++ + W + L S +G+D Sbjct: 262 RLESTLNYGMERVWCVASLRGSNNVALGYD 291 Score = 40.0 bits (92), Expect = 0.001, Method: Compositional matrix adjust. Identities = 43/193 (22%), Positives = 89/193 (46%), Gaps = 9/193 (4%) Query: 94 ILVASDSGAVELWELDENETLIVSKFCKYEHDDI-VSTVSVLSSGTQAVSGSKDICIKVW 152 +L + +G+V +W E +TL+ + +E D+ V ++ V+G+ D+ I+V+ Sbjct: 30 MLASLYNGSVCVWN-HETQTLVKT----FEVCDLPVRAAKFVARKNWVVTGADDMQIRVF 84 Query: 153 DLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPG 212 + + + AH+ + C+A P + + L+ S+D I LWD SQ+ Sbjct: 85 NYNTLERVHMFEAHSDYIRCIAVHPTQPFI-LTSSDDMLIKLWDWDKKWSCSQVFEGHTH 143 Query: 213 YLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGL-VFSPHSVPFL 271 Y+ + +P+ + F + T+ + S+S + H + V + +S P+L Sbjct: 144 YV-MQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYSGGDKPYL 202 Query: 272 ASLSEDCSLAVLD 284 S ++D + + D Sbjct: 203 ISGADDRLVKIWD 215 Score = 38.9 bits (89), Expect = 0.003, Method: Compositional matrix adjust. Identities = 35/147 (23%), Positives = 62/147 (42%), Gaps = 6/147 (4%) Query: 94 ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWD 153 IL +SD ++LW+ D+ + S+ + ++ V Q S S D IKVW Sbjct: 114 ILTSSDDMLIKLWDWDKKWS--CSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQ 171 Query: 154 LAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRIL-LWDTRCPKPASQIGCSAPG 212 L + H V C+ D +L D+R++ +WD + + A Sbjct: 172 LGSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQN 231 Query: 213 YLPTSLAWHPQQSEVFVFGDENGTVSL 239 + ++HP+ + + G E+GTV + Sbjct: 232 V--SCASFHPELP-IIITGSEDGTVRI 255 >4V6W-Ag nrPDB Length = 318 Score = 49.3 bits (116), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 34/106 (32%), Positives = 50/106 (47%), Gaps = 3/106 (2%) Query: 94 ILVASDSGAVELWEL--DENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKV 151 I+ AS + +W+L DE+ + Y H +S V + S G A+SGS D +++ Sbjct: 31 IISASRDKTLIVWKLTRDEDTNYGYPQKRLYGHSHFISDVVLSSDGNYALSGSWDQTLRL 90 Query: 152 WDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDT 197 WDLA + H V VA S + +S S D I LW+T Sbjct: 91 WDLAAGKTTRRFEGHTKDVLSVAFSADNRQI-VSGSRDKTIKLWNT 135 Score = 38.1 bits (87), Expect = 0.005, Method: Compositional matrix adjust. Identities = 34/110 (30%), Positives = 50/110 (45%), Gaps = 10/110 (9%) Query: 91 ERGILVASDSGAVELWELDENETLIVSKFCKYE--HDDIVSTVSVLSSGTQ--AVSGSKD 146 R I+ S ++LW TL KF E H D VS V + + VS D Sbjct: 118 NRQIVSGSRDKTIKLWN-----TLAECKFTIQEDGHTDWVSCVRFSPNHSNPIIVSCGWD 172 Query: 147 ICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWD 196 +KVW+LA + +++ H + V SP S+ S +D++ LLWD Sbjct: 173 RTVKVWNLANCKLKNNHHGHNGYLNTVTVSP-DGSLCTSGGKDSKALLWD 221 Score = 32.3 bits (72), Expect = 0.33, Method: Compositional matrix adjust. Identities = 29/106 (27%), Positives = 46/106 (43%), Gaps = 5/106 (4%) Query: 118 KFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASP 177 K + H+ ++TV+V G+ SG KD +WDL L + H + + SP Sbjct: 186 KNNHHGHNGYLNTVTVSPDGSLCTSGGKDSKALLWDLNDGKNLYTLE-HNDIINALCFSP 244 Query: 178 HKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQ 223 ++ +L + I +WD C K ++ PTS A PQ Sbjct: 245 NR--YWLCVAYGPSIKIWDLACKKTVEELRPEVVS--PTSKADQPQ 286 >6G51-g nrPDB Length = 317 Score = 48.9 bits (115), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 34/105 (32%), Positives = 49/105 (46%), Gaps = 2/105 (1%) Query: 94 ILVASDSGAVELWELDENETLI-VSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVW 152 IL AS + +W+L +ET + + H VS V + S G A+SGS D +++W Sbjct: 31 ILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLW 90 Query: 153 DLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDT 197 DL + H V VA S + +S S D I LW+T Sbjct: 91 DLTTGTTTRRFVGHTKDVLSVAFSSDNRQI-VSGSRDKTIKLWNT 134 Score = 35.4 bits (80), Expect = 0.039, Method: Compositional matrix adjust. Identities = 47/165 (28%), Positives = 69/165 (41%), Gaps = 23/165 (13%) Query: 38 SDGALLLGASSLSGRCWAGSLWLFKDPCAAPNEGFC--SAGVQTEAGVADLTWVGERGIL 95 SDG L S W G+L L+ F + V + A +D R I+ Sbjct: 73 SDGQFALSGS------WDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSD-----NRQIV 121 Query: 96 VASDSGAVELWELDENETLIVSKFCKYE--HDDIVSTV--SVLSSGTQAVSGSKDICIKV 151 S ++LW TL V K+ + H + VS V S SS VS D +KV Sbjct: 122 SGSRDKTIKLWN-----TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKV 176 Query: 152 WDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWD 196 W+LA + +++ H + V SP S+ S +D + +LWD Sbjct: 177 WNLANCKLKTNHIGHTGYLNTVTVSP-DGSLCASGGKDGQAMLWD 220 Score = 28.1 bits (61), Expect = 6.4, Method: Compositional matrix adjust. Identities = 26/104 (25%), Positives = 46/104 (44%), Gaps = 16/104 (15%) Query: 101 GAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDL------ 154 G LW+L+E + L + DI++ + S + + IK+WDL Sbjct: 214 GQAMLWDLNEGKHLYT-----LDGGDIINAL-CFSPNRYWLCAATGPSIKIWDLEGKIIV 267 Query: 155 ---AQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLW 195 Q+V+ +S +A Q T +A S ++F + DN + +W Sbjct: 268 DELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYT-DNLVRVW 310 >5WJC-A nrPDB Length = 430 Score = 48.5 bits (114), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 46/188 (24%), Positives = 69/188 (36%), Gaps = 26/188 (13%) Query: 158 VVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPK---------PASQIGC 208 + +S H V P K + + E ++DT C A G Sbjct: 122 IEISQKIPHDGDVNRARYMPQKPEIIATMGEGGNAYIFDTTCHDALTTGEALPQAVLKGH 181 Query: 209 SAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVD----------TKSTSCVLSSAVHSQCV 258 +A G+ L W+P G E+ + L D TK S + H+ V Sbjct: 182 TAEGF---GLCWNPNLPGNLATGAEDQVICLWDVQTQSFTSSETKVISPIAKYHRHTDIV 238 Query: 259 TGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRS----QAHRDFVRDATWSPLNHSLLT 314 + F P LAS+S+DC+L + D+ L+ + QAH + +P N LL Sbjct: 239 NDVQFHPQHEALLASVSDDCTLQIHDTRLNPEEEAPKVIQAHSKAINAVAINPFNDYLLA 298 Query: 315 TVGWDHQV 322 T D V Sbjct: 299 TASADKTV 306 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 48/193 (24%), Positives = 77/193 (39%), Gaps = 27/193 (13%) Query: 142 SGSKDICIKVWDLAQQVVLSS----------YRAHAAQVTCVAASPHKDSVFLSCSEDNR 191 +G++D I +WD+ Q SS Y H V V P +++ S S+D Sbjct: 200 TGAEDQVICLWDVQTQSFTSSETKVISPIAKYHRHTDIVNDVQFHPQHEALLASVSDDCT 259 Query: 192 ILLWDTRC-PKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLS 250 + + DTR P+ + A ++A +P + + TV+L D ++ L Sbjct: 260 LQIHDTRLNPEEEAPKVIQAHSKAINAVAINPFNDYLLATASADKTVALWDLRNPYQRLH 319 Query: 251 SAV-HSQCVTGLVFSPHSVPFLASLSEDCSLAVL---------------DSSLSELFRSQ 294 + H V GL +SPH P LAS S D + + D S LF Sbjct: 320 TLEGHEDEVYGLEWSPHDEPILASSSTDRRVCIWDLEKIGEEQTPEDAEDGSPELLFMHG 379 Query: 295 AHRDFVRDATWSP 307 H + + + +W P Sbjct: 380 GHTNRISEFSWCP 392 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 26/94 (27%), Positives = 43/94 (45%), Gaps = 5/94 (5%) Query: 112 ETLIVSKFCKY-EHDDIVSTVSVLSSGTQAVSGSKDIC-IKVWDLA---QQVVLSSYRAH 166 ET ++S KY H DIV+ V ++ D C +++ D ++ +AH Sbjct: 221 ETKVISPIAKYHRHTDIVNDVQFHPQHEALLASVSDDCTLQIHDTRLNPEEEAPKVIQAH 280 Query: 167 AAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCP 200 + + VA +P D + + S D + LWD R P Sbjct: 281 SKAINAVAINPFNDYLLATASADKTVALWDLRNP 314 Score = 39.3 bits (90), Expect = 0.002, Method: Compositional matrix adjust. Identities = 38/172 (22%), Positives = 74/172 (43%), Gaps = 13/172 (7%) Query: 164 RAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPK-PASQIGCSAP--GY-----LP 215 + H A+ + +P+ + +ED I LWD + +S+ +P Y + Sbjct: 179 KGHTAEGFGLCWNPNLPGNLATGAEDQVICLWDVQTQSFTSSETKVISPIAKYHRHTDIV 238 Query: 216 TSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAV---HSQCVTGLVFSPHSVPFLA 272 + +HPQ + ++ T+ + DT+ + V HS+ + + +P + LA Sbjct: 239 NDVQFHPQHEALLASVSDDCTLQIHDTRLNPEEEAPKVIQAHSKAINAVAINPFNDYLLA 298 Query: 273 SLSEDCSLAVLD--SSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQV 322 + S D ++A+ D + L + H D V WSP + +L + D +V Sbjct: 299 TASADKTVALWDLRNPYQRLHTLEGHEDEVYGLEWSPHDEPILASSSTDRRV 350 >4L9O-A nrPDB Length = 349 Score = 47.4 bits (111), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 51/217 (23%), Positives = 91/217 (41%), Gaps = 17/217 (7%) Query: 124 HDDIVSTVSVLSSGTQAVSGSKDICIKVWDL--AQQVVLSSYRAHAAQVTCVA-ASPHKD 180 HDD++ + G + + S D IK++++ Q ++ + H V VA A P Sbjct: 68 HDDLIHDAVLDYYGRRLATCSSDKTIKIFEIDGENQRLVETLIGHEGPVWQVAWAHPKFG 127 Query: 181 SVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQ-SEVFVFGDENGTVSL 239 + SCS D ++L+W S S++W P + V + +G +S+ Sbjct: 128 VILASCSYDGKVLIWKEDNGVWNKVAEHSVHQASVNSVSWAPHEYGPVLLCASSDGKISI 187 Query: 240 VDTKSTSCVLSSAV--HSQCVTGLVFSPHSVP-----FLASLSED-CSLAVLDSSLSELF 291 V+ K + + H+ V ++P S+P F++ ++ + D + Sbjct: 188 VEFKDGGALEPIVIQGHAIGVNAASWAPISLPDNTRRFVSGGCDNLVKIWRYDDAAKTFI 247 Query: 292 RS---QAHRDFVRDATWSP--LNHSLLTTVGWDHQVV 323 Q H D+VRD WSP L+ S + T D V+ Sbjct: 248 EEEAFQGHSDWVRDVAWSPSRLSKSYIATASQDRTVL 284 >2H9P-A nrPDB Length = 329 Score = 47.4 bits (111), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 55/229 (24%), Positives = 96/229 (41%), Gaps = 19/229 (8%) Query: 80 EAGVADLTWVGERGILV-ASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGT 138 + G++D+ W + +LV ASD +++W++ + L K H + V + Sbjct: 82 KLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLK----GHSNYVFCCNFNPQSN 137 Query: 139 QAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDT- 197 VSGS D +++WD+ L + AH+ V+ V + S+ +S S D +WDT Sbjct: 138 LIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN-RDGSLIVSSSYDGLCRIWDTA 196 Query: 198 --RCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHS 255 +C K + I P P S + + + T+ L D C+ + H Sbjct: 197 SGQCLK--TLIDDDNP---PVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHK 251 Query: 256 Q---CVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRS-QAHRDFV 300 C+ FS ++ S SED + + + E+ + Q H D V Sbjct: 252 NEKYCIFA-NFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVV 299 Score = 41.6 bits (96), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 28/109 (25%), Positives = 53/109 (48%), Gaps = 2/109 (1%) Query: 92 RGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKV 151 + IL A+ ++LW+ + + L K E I + SV + G VSGS+D + + Sbjct: 222 KYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSV-TGGKWIVSGSEDNLVYI 280 Query: 152 WDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNR-ILLWDTRC 199 W+L + ++ + H V A P ++ + + E+++ I LW + C Sbjct: 281 WNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 329 >5M25-A nrPDB Length = 434 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 55/227 (24%), Positives = 95/227 (41%), Gaps = 19/227 (8%) Query: 82 GVADLTWVGERGILV-ASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQA 140 G++D+ W + +LV ASD +++W++ + L K H + V + Sbjct: 189 GISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLK----GHSNYVFCCNFNPQSNLI 244 Query: 141 VSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDT--- 197 VSGS D +++WD+ L + AH+ V+ V + S+ +S S D +WDT Sbjct: 245 VSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN-RDGSLIVSSSYDGLCRIWDTASG 303 Query: 198 RCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQ- 256 +C K + I P P S + + + T+ L D C+ + H Sbjct: 304 QCLK--TLIDDDNP---PVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNE 358 Query: 257 --CVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRS-QAHRDFV 300 C+ FS ++ S SED + + + E+ + Q H D V Sbjct: 359 KYCIFA-NFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVV 404 Score = 41.6 bits (96), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 28/109 (25%), Positives = 53/109 (48%), Gaps = 2/109 (1%) Query: 92 RGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKV 151 + IL A+ ++LW+ + + L K E I + SV + G VSGS+D + + Sbjct: 327 KYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSV-TGGKWIVSGSEDNLVYI 385 Query: 152 WDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNR-ILLWDTRC 199 W+L + ++ + H V A P ++ + + E+++ I LW + C Sbjct: 386 WNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 434 >3DM0-A nrPDB Length = 694 Score = 45.4 bits (106), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 37/117 (31%), Positives = 56/117 (47%), Gaps = 4/117 (3%) Query: 94 ILVASDSGAVELWELDENETLI-VSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVW 152 I+ AS ++ LW+L +++ V++ H V V + S G A+SGS D +++W Sbjct: 398 IVSASRDKSIILWKLTKDDKAYGVAQRRLTGHSHFVEDVVLSSDGQFALSGSWDGELRLW 457 Query: 153 DLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDT--RCPKPASQIG 207 DLA V + H V VA S + +S S D I LW+T C S+ G Sbjct: 458 DLAAGVSTRRFVGHTKDVLSVAFSLDNRQI-VSASRDRTIKLWNTLGECKYTISEGG 513 Score = 36.6 bits (83), Expect = 0.018, Method: Compositional matrix adjust. Identities = 24/73 (32%), Positives = 40/73 (54%), Gaps = 3/73 (4%) Query: 124 HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVF 183 H VSTV+V G+ SG KD + +WDLA+ L S A++ + + SP++ + Sbjct: 560 HTGYVSTVAVSPDGSLCASGGKDGVVLLWDLAEGKKLYSLEANSV-IHALCFSPNR--YW 616 Query: 184 LSCSEDNRILLWD 196 L + ++ I +WD Sbjct: 617 LCAATEHGIKIWD 629 Score = 31.2 bits (69), Expect = 0.73, Method: Compositional matrix adjust. Identities = 43/182 (23%), Positives = 70/182 (38%), Gaps = 28/182 (15%) Query: 158 VVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWD-TRCPKPASQIGCSAPGYLPT 216 V+ + RAH VT +A + +S S D I+LW T+ K A G Sbjct: 373 VLKGTMRAHTDMVTAIATPIDNADIIVSASRDKSIILWKLTKDDK--------AYGVAQR 424 Query: 217 SLAWHPQQSEVFVF---------GDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHS 267 L H E V G +G + L D + H++ V + FS + Sbjct: 425 RLTGHSHFVEDVVLSSDGQFALSGSWDGELRLWDLAAGVSTRRFVGHTKDVLSVAFSLDN 484 Query: 268 VPFLASLSEDCSLAVLDS------SLSELFRSQAHRDFVRDATWSPLN-HSLLTTVGWDH 320 + S S D ++ + ++ ++SE + HRD+V +SP + + WD Sbjct: 485 RQ-IVSASRDRTIKLWNTLGECKYTISE--GGEGHRDWVSCVRFSPNTLQPTIVSASWDK 541 Query: 321 QV 322 V Sbjct: 542 TV 543 >5WYK-BB nrPDB Length = 943 Score = 45.1 bits (105), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 30/103 (29%), Positives = 48/103 (46%), Gaps = 6/103 (5%) Query: 96 VASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLA 155 V G +++W+L L+ H ++ + +GT+ +SGSKD I VWDL Sbjct: 96 VGYADGVIKVWDLMSKTVLLNFN----GHKAAITLLQFDGTGTRLISGSKDSNIIVWDLV 151 Query: 156 QQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTR 198 +V L R+H +T + +S S+D I LWD + Sbjct: 152 GEVGLYKLRSHKDSITGFWCQG--EDWLISTSKDGMIKLWDLK 192 Score = 33.5 bits (75), Expect = 0.13, Method: Compositional matrix adjust. Identities = 27/108 (25%), Positives = 47/108 (43%), Gaps = 11/108 (10%) Query: 92 RGILVASDSGAVELWELDENETLIVSKFCK---YEHDDIVSTVSVLSSGTQAVSGSKDIC 148 + I+ +S +++W LD + C + H D + V L S SKD Sbjct: 586 KMIITSSADKNIKIWGLDFGD-------CHKSLFAHQDSIMNVKFLPQSHNFFSCSKDAV 638 Query: 149 IKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWD 196 +K WD + + AH ++V +A + V +S S D+ I +W+ Sbjct: 639 VKYWDGEKFECIQKLYAHQSEVWALAVATDGGFV-VSSSHDHSIRIWE 685 Score = 32.7 bits (73), Expect = 0.23, Method: Compositional matrix adjust. Identities = 16/55 (29%), Positives = 30/55 (54%), Gaps = 3/55 (5%) Query: 141 VSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLW 195 +S SKD IK+WDL + ++ AH + +A KD + ++ D+++ +W Sbjct: 178 ISTSKDGMIKLWDLKTHQCIETHIAHTGECWGLAV---KDDLLITTGTDSQVKIW 229 Score = 30.8 bits (68), Expect = 0.96, Method: Compositional matrix adjust. Identities = 25/99 (25%), Positives = 36/99 (36%), Gaps = 7/99 (7%) Query: 122 YEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDS 181 Y H V ++ + ++ S D IK+W L S AH + V P + Sbjct: 570 YGHKLPVLSIDISFDSKMIITSSADKNIKIWGLDFGDCHKSLFAHQDSIMNVKFLPQSHN 629 Query: 182 VFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAW 220 F SCS+D + WD + C Y S W Sbjct: 630 -FFSCSKDAVVKYWD------GEKFECIQKLYAHQSEVW 661 Score = 28.5 bits (62), Expect = 4.5, Method: Compositional matrix adjust. Identities = 15/61 (24%), Positives = 33/61 (54%), Gaps = 3/61 (4%) Query: 94 ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWD 153 +++ + +G ++L++L + L + HD + ++ + S G + V+GS D +K WD Sbjct: 445 VILGTRNGELQLFDLASSSLLDT---IEDAHDAAIWSLDLTSDGKRLVTGSADKTVKFWD 501 Query: 154 L 154 Sbjct: 502 F 502 >4LG8-A nrPDB Length = 354 Score = 45.1 bits (105), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 36/140 (25%), Positives = 69/140 (49%), Gaps = 8/140 (5%) Query: 142 SGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFL-SCSEDNRILLWDTRCP 200 +G+ D IK+WDL ++ ++++ H+ +T +A S ++ +L + ++D+ + LWD R Sbjct: 217 TGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFS--ENGYYLATAADDSSVKLWDLRKL 274 Query: 201 KPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTG 260 K + + SL + + + + G + V + K + +L HS TG Sbjct: 275 KNFKTLQLD-NNFEVKSLIFDQSGTYLALGGTD---VQIYICKQWTEILHFTEHSGLTTG 330 Query: 261 LVFSPHSVPFLASLSEDCSL 280 + F H+ F+AS D SL Sbjct: 331 VAFGHHA-KFIASTGMDRSL 349 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 40/170 (23%), Positives = 74/170 (43%), Gaps = 3/170 (1%) Query: 124 HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVF 183 H V++V S S S D I++W + + RAH + VT ++ D Sbjct: 113 HTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGD-YL 171 Query: 184 LSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTK 243 LS S+D D + + +++ G T +HP +F G + + + D K Sbjct: 172 LSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHP-DGLIFGTGTMDSQIKIWDLK 230 Query: 244 STSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRS 293 + V + HS +T + FS + +LA+ ++D S+ + D + F++ Sbjct: 231 ERTNVANFPGHSGPITSIAFSENGY-YLATAADDSSVKLWDLRKLKNFKT 279 >3JAP-g nrPDB Length = 326 Score = 44.7 bits (104), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 30/93 (32%), Positives = 43/93 (46%), Gaps = 2/93 (2%) Query: 106 WELDENETLIVSKFCKYE-HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYR 164 W L ENE Y+ H IV V V + G AVS S D +++W+LA + + Sbjct: 46 WRLTENEQQFGVPVRSYKGHSHIVQDVVVSADGNYAVSASWDKTLRLWNLATGNSEARFV 105 Query: 165 AHAAQVTCVAASPHKDSVFLSCSEDNRILLWDT 197 H V VA + + +S S D I +W+T Sbjct: 106 GHTGDVLSVAIDANSSKI-ISASRDKTIRVWNT 137 Score = 35.4 bits (80), Expect = 0.033, Method: Compositional matrix adjust. Identities = 32/132 (24%), Positives = 56/132 (42%), Gaps = 11/132 (8%) Query: 103 VELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSS 162 V W L+E+ I + F H++ ++ V G+ A S KD I VW+L + + Sbjct: 183 VRSWSLNEDSYRIEADFIG--HNNYINVVQPSPDGSLAASAGKDGQIYVWNLKHKSAFMN 240 Query: 163 YRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLP------T 216 + A +V +A SP + +L+ + + I ++D ++ GY Sbjct: 241 FDAK-DEVFALAFSPSR--FWLTAATASGIKIYDLENEVLIDELKPEFAGYTKAQDPHAV 297 Query: 217 SLAWHPQQSEVF 228 SLAW +F Sbjct: 298 SLAWSADGQTLF 309 >6J6H-n nrPDB Length = 455 Score = 44.7 bits (104), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 35/157 (22%), Positives = 67/157 (42%), Gaps = 9/157 (5%) Query: 136 SGTQAVSGSKDICIKVWDLAQQV-VLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILL 194 +G +SG D IK+WD L ++ H + + + S FLS S D + + Sbjct: 174 TGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQS-FLSSSFDRSVKI 232 Query: 195 WDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTK---STSCVLSS 251 WDT K +++ ++ P + P F+ G N + D + + V + Sbjct: 233 WDTETGKVKTRLHLNS---TPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTY 289 Query: 252 AVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLS 288 H + L + P F++S SED ++ + ++ ++ Sbjct: 290 DHHLSSILALKYFPDGSKFISS-SEDKTVRIWENQIN 325 Score = 34.7 bits (78), Expect = 0.068, Method: Compositional matrix adjust. Identities = 20/70 (28%), Positives = 34/70 (48%), Gaps = 2/70 (2%) Query: 156 QQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLP 215 Q ++ +Y H + + + P S F+S SED + +W+ + P QI +A +P Sbjct: 282 NQGLVQTYDHHLSSILALKYFP-DGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMP 340 Query: 216 TSLAWHPQQS 225 L HP Q+ Sbjct: 341 F-LNVHPSQN 349 >6EMK-B nrPDB Length = 303 Score = 44.3 bits (103), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 35/127 (27%), Positives = 59/127 (46%), Gaps = 5/127 (3%) Query: 71 GFCSAGVQ-TEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVS 129 G CS +Q +++ V L ++ +L + V L+++ V+ F H V+ Sbjct: 22 GVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRTTNPNPVASF--EGHRGNVT 79 Query: 130 TVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSED 189 +VS V+ S+D IKVWD+ + +Y+ H A V V P++ +SC D Sbjct: 80 SVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAPVNEVVIHPNQGE-LISCDRD 137 Query: 190 NRILLWD 196 I +WD Sbjct: 138 GNIRIWD 144 Score = 28.9 bits (63), Expect = 3.0, Method: Compositional matrix adjust. Identities = 11/34 (32%), Positives = 19/34 (55%) Query: 141 VSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVA 174 V+ S D +++WDL+ + ++ Y H CVA Sbjct: 266 VTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVA 299 >5Z56-q nrPDB Length = 504 Score = 44.3 bits (103), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 36/140 (25%), Positives = 69/140 (49%), Gaps = 8/140 (5%) Query: 142 SGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFL-SCSEDNRILLWDTRCP 200 +G+ D IK+WDL ++ ++++ H+ +T +A S ++ +L + ++D+ + LWD R Sbjct: 367 TGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFS--ENGYYLATAADDSSVKLWDLRKL 424 Query: 201 KPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTG 260 K + + SL + + + + G + V + K + +L HS TG Sbjct: 425 KNFKTLQLDN-NFEVKSLIFDQSGTYLALGGTD---VQIYICKQWTEILHFTEHSGLTTG 480 Query: 261 LVFSPHSVPFLASLSEDCSL 280 + F H+ F+AS D SL Sbjct: 481 VAFGHHA-KFIASTGMDRSL 499 Score = 41.2 bits (95), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 40/170 (23%), Positives = 74/170 (43%), Gaps = 3/170 (1%) Query: 124 HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVF 183 H V++V S S S D I++W + + RAH + VT ++ D Sbjct: 263 HTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGD-YL 321 Query: 184 LSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTK 243 LS S+D D + + +++ G T +HP +F G + + + D K Sbjct: 322 LSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHP-DGLIFGTGTMDSQIKIWDLK 380 Query: 244 STSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRS 293 + V + HS +T + FS + +LA+ ++D S+ + D + F++ Sbjct: 381 ERTNVANFPGHSGPITSIAFSENGY-YLATAADDSSVKLWDLRKLKNFKT 429 >4XYI-A nrPDB Length = 430 Score = 44.3 bits (103), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 47/203 (23%), Positives = 81/203 (39%), Gaps = 55/203 (27%) Query: 132 SVLSSGTQAVSGSKDICIKVWDLAQQVV----------LSSYRAHAAQVTCVAASPHKDS 181 + + GT A +G++D I VWD+ + + +S Y H A V + ++ Sbjct: 191 NFIQEGTLA-TGTEDTSICVWDIKGKSLSLEKSIDVAPVSVYHRHTAVVNDLQFHLQHEA 249 Query: 182 VFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVD 241 + S S+D + + DTR P +S Sbjct: 250 LLTSVSDDCTLQIHDTRLPSSSS------------------------------------- 272 Query: 242 TKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLD-SSLSELFRS-QAHRDF 299 ++ CV H Q V G+ F+P + LA+ S D ++A+ D L++ + + H D Sbjct: 273 --ASQCV---KAHEQPVNGVAFNPFNDYLLATASADHTVALWDLRRLNQRLHTLEGHEDE 327 Query: 300 VRDATWSPLNHSLLTTVGWDHQV 322 V + WSP + +L T D +V Sbjct: 328 VYNVQWSPHDEPILVTSSTDRRV 350 Score = 42.0 bits (97), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 35/119 (29%), Positives = 50/119 (42%), Gaps = 14/119 (11%) Query: 218 LAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAV----------HSQCVTGLVFSPHS 267 L W+ Q G E+ ++ + D K S L ++ H+ V L F Sbjct: 188 LGWNFIQEGTLATGTEDTSICVWDIKGKSLSLEKSIDVAPVSVYHRHTAVVNDLQFHLQH 247 Query: 268 VPFLASLSEDCSLAVLDSSL-SELFRSQ---AHRDFVRDATWSPLNHSLLTTVGWDHQV 322 L S+S+DC+L + D+ L S SQ AH V ++P N LL T DH V Sbjct: 248 EALLTSVSDDCTLQIHDTRLPSSSSASQCVKAHEQPVNGVAFNPFNDYLLATASADHTV 306 Score = 33.9 bits (76), Expect = 0.11, Method: Compositional matrix adjust. Identities = 60/312 (19%), Positives = 119/312 (38%), Gaps = 43/312 (13%) Query: 5 TPPPLVPPAAR-EWNLPPNAPACMERQLEAARYRSDGALLLGASSLSGRCWAGSLWLFKD 63 TP + P + ++ L E + AR+ ++ L+G + L L+++ Sbjct: 107 TPSKMKPANFKGDYGLDIVQKIHHEGDVNKARFMPQNPDIIATLGLNGNGYIFDLNLYRE 166 Query: 64 -PCAAPNEGFCSAGVQTEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFCK- 121 P C +E ++ E + ++ ++ +W++ + ++L + K Sbjct: 167 QPIVQTGHQACLRHHTSEGFGLGWNFIQEGTLATGTEDTSICVWDI-KGKSLSLEKSIDV 225 Query: 122 ------YEHDDIVSTVSV-LSSGTQAVSGSKDICIKVWDL-------AQQVVLSSYRAHA 167 + H +V+ + L S S D +++ D A Q V +AH Sbjct: 226 APVSVYHRHTAVVNDLQFHLQHEALLTSVSDDCTLQIHDTRLPSSSSASQCV----KAHE 281 Query: 168 AQVTCVAASPHKDSVFLSCSEDNRILLWDTR--CPKPASQIGCSAPGYLPTSLAWHPQQS 225 V VA +P D + + S D+ + LWD R + + G Y ++ W P Sbjct: 282 QPVNGVAFNPFNDYLLATASADHTVALWDLRRLNQRLHTLEGHEDEVY---NVQWSPHDE 338 Query: 226 EVFV---------------FGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPF 270 + V G+E TV + + + H+ V+ L ++P++ Sbjct: 339 PILVTSSTDRRVCVWDLSKIGEEQ-TVEDSEDGAPELMFMHGGHTNRVSDLSWNPNNKWV 397 Query: 271 LASLSEDCSLAV 282 LASL++D L + Sbjct: 398 LASLADDNILQI 409 >3JB9-g nrPDB Length = 558 Score = 43.9 bits (102), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 39/148 (26%), Positives = 67/148 (45%), Gaps = 8/148 (5%) Query: 136 SGTQAVSGSKDICIKVWDLAQ-QVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILL 194 SG +SGS D IK+W++ + +L +++ HA + ++ S S FLS S D I L Sbjct: 278 SGHLLLSGSMDNQIKIWEVYHDRSLLRTFQGHARPIRDLSFSQDGRS-FLSTSFDKTIKL 336 Query: 195 WDTRCPKPASQIGCSAPGYLPTSLAWH--PQQSEVFVFGDENGTVSLVDTKSTSCVLSSA 252 WDT K + C L + + P + F+ G + + D +S V + Sbjct: 337 WDTELGKC---LNCFNSDRLTNCVKFQVDPDKPNEFLAGTADKRILQFDIRSPDIVQAYD 393 Query: 253 VHSQCVTGLVFSPHSVPFLASLSEDCSL 280 H + + F + F+ + S+D S+ Sbjct: 394 HHLGGINSITFLENGKRFVTT-SDDSSM 420 Score = 38.9 bits (89), Expect = 0.003, Method: Compositional matrix adjust. Identities = 29/109 (26%), Positives = 49/109 (44%), Gaps = 6/109 (5%) Query: 94 ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWD 153 +L S +++WE+ + +L+ + H + +S G +S S D IK+WD Sbjct: 282 LLSGSMDNQIKIWEVYHDRSLLRTF---QGHARPIRDLSFSQDGRSFLSTSFDKTIKLWD 338 Query: 154 LAQQVVLSSYRAHAAQVTCVA--ASPHKDSVFLSCSEDNRILLWDTRCP 200 L+ + + CV P K + FL+ + D RIL +D R P Sbjct: 339 TELGKCLNCFNSDRL-TNCVKFQVDPDKPNEFLAGTADKRILQFDIRSP 386 Score = 31.2 bits (69), Expect = 0.65, Method: Compositional matrix adjust. Identities = 39/155 (25%), Positives = 66/155 (42%), Gaps = 12/155 (7%) Query: 128 VSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTC--VAASPHKDSVFLS 185 +++++ L +G + V+ S D ++ W+ V + + A A + VA P+ S+ + Sbjct: 399 INSITFLENGKRFVTTSDDSSMRFWEYGTPVPIK-FVADIAMHSMPRVALRPNGKSI--A 455 Query: 186 C-SEDNRILLWDT----RCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLV 240 C S DN I ++ R K G S GY + + P VF GD +G Sbjct: 456 CQSLDNCIYVYSAYEKYRQNKKKVFKGYSCSGY-SLEVGFSPDGRFVFS-GDSSGNACFW 513 Query: 241 DTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLS 275 D K+ + HS V + F P +A+ S Sbjct: 514 DWKTCKLMAKLPAHSGPVQSMAFHPQETSKVATSS 548 >5K1B-B nrPDB Length = 677 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 26/77 (33%), Positives = 38/77 (49%), Gaps = 1/77 (1%) Query: 124 HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVF 183 H D V + + GTQ +SGS D I++W L QQ +++YR H V + + V+ Sbjct: 209 HTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVY 268 Query: 184 LSCSEDNRILLWDTRCP 200 S D +I D R P Sbjct: 269 -SGGRDRKIYCTDLRNP 284 Score = 41.2 bits (95), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 23/73 (31%), Positives = 37/73 (50%), Gaps = 1/73 (1%) Query: 124 HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVF 183 H D V+ + + +G +S S D +KVW+ + +S+ R H V +A + K+ V Sbjct: 74 HTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELV- 132 Query: 184 LSCSEDNRILLWD 196 S D +I LWD Sbjct: 133 ASAGLDRQIFLWD 145 Score = 32.0 bits (71), Expect = 0.43, Method: Compositional matrix adjust. Identities = 39/169 (23%), Positives = 66/169 (39%), Gaps = 18/169 (10%) Query: 69 NEGFCSAGVQTEAGVADLTWVGERGILVASD--SGAVELWELD-------ENETLIVSKF 119 ++GFC + ++T + LVAS + LW+++ N T+ S Sbjct: 105 HKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSL 164 Query: 120 CKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHK 179 + D + ++++ GT VSGS + ++VWD L + H V + + Sbjct: 165 SG--NKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLN-RD 221 Query: 180 DSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVF 228 + LS S D I LW Q C A + W Q ++ F Sbjct: 222 GTQCLSGSSDGTIRLW------SLGQQRCIATYRVHDEGVWALQVNDAF 264 >3BG0-A nrPDB Length = 316 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 45/211 (21%), Positives = 83/211 (39%), Gaps = 27/211 (12%) Query: 124 HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQ--QVVLSSYRAHAAQVTCVA-ASPHKD 180 H+D++ + GT+ + S D +K++D+ Q++++ R H V VA A P Sbjct: 12 HEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYG 71 Query: 181 SVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSE-VFVFGDENGTVSL 239 ++ SCS D ++++W + S+ W P + G +G +SL Sbjct: 72 NILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISL 131 Query: 240 VDTKSTSCVLSSAVHSQCVTG---LVFSPHSVP----------------FLASLSEDCSL 280 + +++ G + ++P VP AS D + Sbjct: 132 LTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLI 191 Query: 281 AVL----DSSLSELFRSQAHRDFVRDATWSP 307 + D E + +AH D+VRD W+P Sbjct: 192 KLWKEEEDGQWKEEQKLEAHSDWVRDVAWAP 222 >6QDV-o nrPDB Length = 513 Score = 43.5 bits (101), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 43/188 (22%), Positives = 75/188 (39%), Gaps = 16/188 (8%) Query: 141 VSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCP 200 V+G D I WD+ ++ Y H V + ++ F+S S+D + +W+ P Sbjct: 326 VAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVD-ENRRFVSTSDDKSLRVWEWDIP 384 Query: 201 KPASQIGCSAPGYLPTS--------LAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSA 252 I + +P LA +++ +FG +N L K + + Sbjct: 385 VDFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQN-RFRLNKKKIFKGHMVAG 443 Query: 253 VHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELF-RSQAHRDFVRDATWSPLNHS 311 Q + FSP + ++ S + L + D ++L+ R +AH A W P S Sbjct: 444 YACQ----VDFSP-DMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETS 498 Query: 312 LLTTVGWD 319 + T GWD Sbjct: 499 KVITCGWD 506 Score = 42.7 bits (99), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 51/201 (25%), Positives = 89/201 (44%), Gaps = 15/201 (7%) Query: 91 ERGILVA--SDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDIC 148 ++ + VA SD V+ W++ E IV ++ + H V+T+ + + VS S D Sbjct: 321 KQNLFVAGMSDKKIVQ-WDIRSGE--IVQEYDR--HLGAVNTIVFVDENRRFVSTSDDKS 375 Query: 149 IKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSC-SEDNRILLWDT----RCPKPA 203 ++VW+ V Y A + + A + + +L+C S DN+IL++ R K Sbjct: 376 LRVWEWDIPVDFK-YIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKK 434 Query: 204 SQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVF 263 G GY + + P S V + GD NG +++ D K+T H + G V+ Sbjct: 435 IFKGHMVAGY-ACQVDFSPDMSYV-ISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVW 492 Query: 264 SPHSVPFLASLSEDCSLAVLD 284 PH + + D + + D Sbjct: 493 HPHETSKVITCGWDGLIKLWD 513 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 38/145 (26%), Positives = 60/145 (41%), Gaps = 19/145 (13%) Query: 103 VELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSS 162 ++LWE+ E + F H V + ++GTQ +S + D +K+WD +S Sbjct: 247 IKLWEV-YGERRCLRTFIG--HSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISR 303 Query: 163 YRAHAAQVTCVAASPHKD--SVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAW 220 + CV +P +D ++F++ D +I+ WD R G + Sbjct: 304 FTNRKVPY-CVKFNPDEDKQNLFVAGMSDKKIVQWDIRS------------GEIVQEYDR 350 Query: 221 HPQQSEVFVFGDENGT-VSLVDTKS 244 H VF DEN VS D KS Sbjct: 351 HLGAVNTIVFVDENRRFVSTSDDKS 375 >5YZG-W nrPDB Length = 579 Score = 43.5 bits (101), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 42/188 (22%), Positives = 75/188 (39%), Gaps = 16/188 (8%) Query: 141 VSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCP 200 V+G D I WD+ ++ Y H V + ++ F+S S+D + +W+ P Sbjct: 392 VAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFV-DENRRFVSTSDDKSLRVWEWDIP 450 Query: 201 KPASQIGCSAPGYLPTS--------LAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSA 252 I + +P LA +++ +FG +N L K + Sbjct: 451 VDFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQN-RFRLNKKK----IFKGH 505 Query: 253 VHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELF-RSQAHRDFVRDATWSPLNHS 311 + + + FSP + ++ S + L + D ++L+ R +AH A W P S Sbjct: 506 MVAGYACQVDFSP-DMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETS 564 Query: 312 LLTTVGWD 319 + T GWD Sbjct: 565 KVITCGWD 572 Score = 42.7 bits (99), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 49/183 (26%), Positives = 83/183 (45%), Gaps = 15/183 (8%) Query: 91 ERGILVA--SDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDIC 148 ++ + VA SD V+ W++ E IV ++ + H V+T+ + + VS S D Sbjct: 387 KQNLFVAGMSDKKIVQ-WDIRSGE--IVQEYDR--HLGAVNTIVFVDENRRFVSTSDDKS 441 Query: 149 IKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSC-SEDNRILLWDT----RCPKPA 203 ++VW+ V Y A + + A + + +L+C S DN+IL++ R K Sbjct: 442 LRVWEWDIPVDFK-YIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKK 500 Query: 204 SQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVF 263 G GY + + P S V + GD NG +++ D K+T H + G V+ Sbjct: 501 IFKGHMVAGY-ACQVDFSPDMSYV-ISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVW 558 Query: 264 SPH 266 PH Sbjct: 559 HPH 561 Score = 40.0 bits (92), Expect = 0.001, Method: Compositional matrix adjust. Identities = 38/145 (26%), Positives = 60/145 (41%), Gaps = 19/145 (13%) Query: 103 VELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSS 162 ++LWE+ E + F H V + ++GTQ +S + D +K+WD +S Sbjct: 313 IKLWEV-YGERRCLRTFIG--HSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISR 369 Query: 163 YRAHAAQVTCVAASPHKD--SVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAW 220 + CV +P +D ++F++ D +I+ WD R G + Sbjct: 370 FTNRKVPY-CVKFNPDEDKQNLFVAGMSDKKIVQWDIRS------------GEIVQEYDR 416 Query: 221 HPQQSEVFVFGDENGT-VSLVDTKS 244 H VF DEN VS D KS Sbjct: 417 HLGAVNTIVFVDENRRFVSTSDDKS 441 Score = 35.4 bits (80), Expect = 0.038, Method: Compositional matrix adjust. Identities = 18/58 (31%), Positives = 29/58 (50%), Gaps = 4/58 (6%) Query: 141 VSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAA--SPHKDSVFLSCSEDNRILLWD 196 +SG + + +WD + S ++AH C+ A PH+ S ++C D I LWD Sbjct: 524 ISGDGNGKLNIWDWKTTKLYSRFKAHDK--VCIGAVWHPHETSKVITCGWDGLIKLWD 579 >6HQA-B nrPDB Length = 722 Score = 42.7 bits (99), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 53/204 (25%), Positives = 80/204 (39%), Gaps = 14/204 (6%) Query: 124 HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVF 183 H V V +S S+D +++W L L SY+ H++ V V SP F Sbjct: 452 HSGAVYGVDFSPDNRYLISCSEDKTVRLWSLDTYTCLVSYKGHSSSVWDVKFSP-MGHYF 510 Query: 184 LSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTS--LAWHPQQSEVFVFGDENGTVSLVD 241 + S D LW P G+L + +HP + +F G + T + D Sbjct: 511 ATASHDQTARLWSCDHIYPLRIFA----GHLNDVDCVEFHPNSTYLFT-GSSDKTARMWD 565 Query: 242 TKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHRDFVR 301 CV HS + L SP +LAS ED + + D S R +A R R Sbjct: 566 IARGECVRVFMGHSGAINCLAVSPDG-RWLASAGEDSVVCLWDISTGR--RIKAMRGHGR 622 Query: 302 DATWS---PLNHSLLTTVGWDHQV 322 + +S ++L + G D+ V Sbjct: 623 SSIYSLAFSREGTVLVSTGADNSV 646 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 30/102 (29%), Positives = 47/102 (46%), Gaps = 7/102 (6%) Query: 96 VASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLA 155 AS LW D L + F + +D V V + T +GS D ++WD+A Sbjct: 512 TASHDQTARLWSCDHIYPLRI--FAGHLND--VDCVEFHPNSTYLFTGSSDKTARMWDIA 567 Query: 156 QQVVLSSYRAHAAQVTCVAASPHKDSVFL-SCSEDNRILLWD 196 + + + H+ + C+A SP D +L S ED+ + LWD Sbjct: 568 RGECVRVFMGHSGAINCLAVSP--DGRWLASAGEDSVVCLWD 607 Score = 33.1 bits (74), Expect = 0.19, Method: Compositional matrix adjust. Identities = 20/105 (19%), Positives = 42/105 (40%), Gaps = 4/105 (3%) Query: 94 ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWD 153 + S +W++ E + V H ++ ++V G S +D + +WD Sbjct: 552 LFTGSSDKTARMWDIARGECVRVF----MGHSGAINCLAVSPDGRWLASAGEDSVVCLWD 607 Query: 154 LAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTR 198 ++ + + R H A + +V +S DN + +WD + Sbjct: 608 ISTGRRIKAMRGHGRSSIYSLAFSREGTVLVSTGADNSVRVWDVK 652 >5WYJ-BE nrPDB Length = 939 Score = 42.0 bits (97), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 29/141 (20%), Positives = 62/141 (43%), Gaps = 5/141 (3%) Query: 125 DDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFL 184 D V +V++ G GS + I ++++ ++ Y+ H VT ++ + + Sbjct: 460 DGFVKSVAMSQCGNFGFIGSSNGSITIYNMQSGILRKKYKLHKRAVTGISLDGMNRKM-V 518 Query: 185 SCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKS 244 SC D + +D ++ AP T++ +H + S++F ++ ++ ++D + Sbjct: 519 SCGLDGIVGFYDFNKSTLLGKLKLDAP---ITAMVYH-RSSDLFALALDDLSIVVIDAVT 574 Query: 245 TSCVLSSAVHSQCVTGLVFSP 265 V HS +T FSP Sbjct: 575 QRVVRQLWGHSNRITAFDFSP 595 >5XYI-g nrPDB Length = 335 Score = 41.6 bits (96), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 44/183 (24%), Positives = 77/183 (42%), Gaps = 12/183 (6%) Query: 90 GERGILV-ASDSGAVELWELDENETLIVSKFCKY-EHDDIVSTVSVLSSGTQAVSGSKDI 147 E LV AS + +W+L+ + + F + H+ VS VS+ + ++ S D Sbjct: 43 NEHNYLVSASRDKSALVWKLNRTQEQWATPFTRLIGHNHFVSDVSLSRDASHLLTSSWDS 102 Query: 148 CIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIG 207 +++WDL+ + + H V V SP + +S DN++ +W+ A ++ Sbjct: 103 TLRLWDLSTRTTKKLFLGHKKDVLGVTFSPCNRRI-ISVGRDNQVKIWNILGENKA-ELQ 160 Query: 208 CSAPGYLPTSLAWHPQQSE----VFVFGDENGTVSLVDT-KSTSCVLSSAVHSQCVTGLV 262 CS+ TS+A P E V G +G V + K + H T + Sbjct: 161 CSS---WVTSVACAPMADETSPLVIAVGCWDGKVYIWSIEKEAKLIKEFKAHDGRCTSVD 217 Query: 263 FSP 265 F+P Sbjct: 218 FTP 220 >6ID0-T nrPDB Length = 514 Score = 41.6 bits (96), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 40/146 (27%), Positives = 63/146 (43%), Gaps = 9/146 (6%) Query: 141 VSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCP 200 V+GS D IK+WDLA + S H + V V S +F SC ED ++ WD Sbjct: 220 VTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLF-SCGEDKQVKCWDLEYN 278 Query: 201 KPASQIGCSAPGYLPT--SLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCV 258 K G+L L HP +V V + T + D ++ + V + + H+ V Sbjct: 279 KVIRHYH----GHLSAVYGLDLHP-TIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAV 333 Query: 259 TGLVFSPHSVPFLASLSEDCSLAVLD 284 V + P + + S D ++ + D Sbjct: 334 -ATVRCQAAEPQIITGSHDTTIRLWD 358 Score = 38.5 bits (88), Expect = 0.004, Method: Compositional matrix adjust. Identities = 34/118 (28%), Positives = 50/118 (42%), Gaps = 6/118 (5%) Query: 124 HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVF 183 H + V+TV ++ Q ++GS D I++WDL + H V V P + F Sbjct: 329 HTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHP-RHYTF 387 Query: 184 LSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVD 241 S S DN I W + P + S + +L V V G +NGT+ L D Sbjct: 388 ASGSPDN-IKQW--KFPDGSFIQNLSGHNAIINTLT--VNSDGVLVSGADNGTMHLWD 440 >4V8M-A7 nrPDB Length = 318 Score = 41.6 bits (96), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 35/123 (28%), Positives = 52/123 (42%), Gaps = 6/123 (4%) Query: 91 ERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSS--GTQAVSGSKDIC 148 R I+ A+ +W + + + + H D VS V S VSG D Sbjct: 121 NRQIVSGGRDNALRVWNV---KGECMHTLSRGAHTDWVSCVRFSPSLDAPVIVSGGWDNL 177 Query: 149 IKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGC 208 +KVWDLA +++ + H VT V SP S+ S +D LWD + S++ Sbjct: 178 VKVWDLATGRLVTDLKGHTNYVTSVTVSP-DGSLCASSDKDGVARLWDLTKGEALSEMAA 236 Query: 209 SAP 211 AP Sbjct: 237 GAP 239 Score = 38.5 bits (88), Expect = 0.004, Method: Compositional matrix adjust. Identities = 22/75 (29%), Positives = 37/75 (49%), Gaps = 1/75 (1%) Query: 124 HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVF 183 H VS V++ ++G AVS S D +++W+L + H V VA SP + Sbjct: 66 HSAFVSDVALSNNGNFAVSASWDHSLRLWNLQNGQCQYKFLGHTKDVLSVAFSPDNRQI- 124 Query: 184 LSCSEDNRILLWDTR 198 +S DN + +W+ + Sbjct: 125 VSGGRDNALRVWNVK 139 >5OPT-p nrPDB Length = 318 Score = 41.2 bits (95), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 24/71 (33%), Positives = 35/71 (49%), Gaps = 1/71 (1%) Query: 141 VSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCP 200 VSG D +KVWD+A +L+ + H +T V SP S+ S +D LWD Sbjct: 170 VSGGWDNLVKVWDIASGRLLTDLKGHTNYITSVTVSP-DGSLCASSDKDGVARLWDLTKG 228 Query: 201 KPASQIGCSAP 211 + S++ AP Sbjct: 229 EALSEMAAGAP 239 Score = 39.3 bits (90), Expect = 0.002, Method: Compositional matrix adjust. Identities = 34/143 (23%), Positives = 63/143 (44%), Gaps = 3/143 (2%) Query: 124 HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVF 183 H VS V++ ++G AVS S D +++W+L V + H V V SP + Sbjct: 66 HSAFVSDVALSNNGDFAVSASWDHSLRLWNLQTGVCQHKFLGHTKDVLSVTFSPDNRQI- 124 Query: 184 LSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQ-QSEVFVFGDENGTVSLVDT 242 +S DN + +W+ + + +G A + + + P ++ + V G + V + D Sbjct: 125 VSGGRDNALRVWNVK-GECLHTLGRGAHTDWVSCVRFSPSLETPLIVSGGWDNLVKVWDI 183 Query: 243 KSTSCVLSSAVHSQCVTGLVFSP 265 S + H+ +T + SP Sbjct: 184 ASGRLLTDLKGHTNYITSVTVSP 206 >5WLC-LU nrPDB Length = 489 Score = 41.2 bits (95), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 32/131 (24%), Positives = 58/131 (44%), Gaps = 7/131 (5%) Query: 136 SGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLW 195 + T A G+K I +WD+ + +S A +T + + ++ + S DN I+L+ Sbjct: 191 NSTFATGGAK---IHLWDVNRLKPVSDLSWGADNITSLKFNQNETDILASTGSDNSIVLY 247 Query: 196 DTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSS-AVH 254 D R P +I ++ W+P ++ FV +E+ D ++ S L+ H Sbjct: 248 DLRTNSPTQKI---VQTMRTNAICWNPMEAFNFVTANEDHNAYYYDMRNLSRSLNVFKDH 304 Query: 255 SQCVTGLVFSP 265 V + FSP Sbjct: 305 VSAVMDVDFSP 315 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 53/236 (22%), Positives = 86/236 (36%), Gaps = 42/236 (17%) Query: 122 YEHDDIVSTVSV-LSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVT--CVAASPH 178 Y H D V ++ S + +GS D IK W+++ + S++AH VT CV Sbjct: 64 YGHRDGVYAIAKNYGSLNKLATGSADGVIKYWNMSTREEFVSFKAHYGLVTGLCVTQPRF 123 Query: 179 KD--------SVFLSCSEDNRILLW----DTRCPKPASQIG--CSAPGYLPT-------- 216 D + LSCS+D + LW D K +S + G + T Sbjct: 124 HDKKPDLKSQNFMLSCSDDKTVKLWSINVDDYSNKNSSDNDSVTNEEGLIRTFDGESAFQ 183 Query: 217 SLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSE 276 + H + S F + L D V + + +T L F+ + LAS Sbjct: 184 GIDSHRENS---TFATGGAKIHLWDVNRLKPVSDLSWGADNITSLKFNQNETDILASTGS 240 Query: 277 DCSLAVLD-------SSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQVVHH 325 D S+ + D + + R+ A W+P+ T DH ++ Sbjct: 241 DNSIVLYDLRTNSPTQKIVQTMRTNA-------ICWNPMEAFNFVTANEDHNAYYY 289 >5WLC-LN nrPDB Length = 776 Score = 40.8 bits (94), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 34/133 (25%), Positives = 53/133 (39%), Gaps = 11/133 (8%) Query: 77 VQTEAGVADLTWVGERGILVASDSGAVELWELDENE--------TLIVSKFCKYEHDDIV 128 ++ EA V L W + ++ G + +W +N+ T+ V K K +V Sbjct: 184 MRQEARVLTLAWKKDDFVIGGCSDGRIRIWSAQKNDENMGRLLHTMKVDKAKK--ESTLV 241 Query: 129 STVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSE 188 +V L Q SG IK WD + S++AH A V C+ + VF S Sbjct: 242 WSVIYLPRTDQIASGDSTGSIKFWDFQFATLNQSFKAHDADVLCLTTDTDNNYVF-SAGV 300 Query: 189 DNRILLWDTRCPK 201 D +I + K Sbjct: 301 DRKIFQFSQNTNK 313 >4BZK-B nrPDB Length = 297 Score = 40.8 bits (94), Expect = 9e-04, Method: Compositional matrix adjust. Identities = 49/215 (22%), Positives = 91/215 (42%), Gaps = 39/215 (18%) Query: 124 HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQV--VLSSYRAHAAQVTCVA-ASPHKD 180 H++++ + G + + S D IK++++ + ++ + H V V A P Sbjct: 8 HNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFG 67 Query: 181 SVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLP-TSLAWHPQQ-SEVFVFGDENGTVS 238 ++ SCS D ++L+W + SQI A S+ W P + + + +G VS Sbjct: 68 TILASCSYDGKVLIWKEENGR-WSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVS 126 Query: 239 LVDTK---STSCVLSSAVHSQCVTGLVFSPHSV-------------PFLA---------- 272 +V+ K +TS ++ A H+ V ++P ++ F+ Sbjct: 127 VVEFKENGTTSPIIIDA-HAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIW 185 Query: 273 SLSEDCSLAVLDSSLSELFRSQAHRDFVRDATWSP 307 + D VL+S+L + H D+VRD WSP Sbjct: 186 KYNSDAQTYVLESTL------EGHSDWVRDVAWSP 214 >3JRP-A nrPDB Length = 379 Score = 40.8 bits (94), Expect = 9e-04, Method: Compositional matrix adjust. Identities = 54/233 (23%), Positives = 98/233 (42%), Gaps = 41/233 (17%) Query: 124 HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQV--VLSSYRAHAAQVTCVA-ASPHKD 180 H++++ + G + + S D IK++++ + ++ + H V V A P Sbjct: 10 HNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFG 69 Query: 181 SVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLP-TSLAWHPQQ-SEVFVFGDENGTVS 238 ++ SCS D ++L+W + SQI A S+ W P + + + +G VS Sbjct: 70 TILASCSYDGKVLIWKEENGR-WSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVS 128 Query: 239 LVDTK---STSCVLSSAVHSQCVTGLVFSPHSV-------------PFLA---------- 272 +V+ K +TS ++ A H+ V ++P ++ F+ Sbjct: 129 VVEFKENGTTSPIIIDA-HAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIW 187 Query: 273 SLSEDCSLAVLDSSLSELFRSQAHRDFVRDATWSP--LNHSLLTTVGWDHQVV 323 + D VL+S+L + H D+VRD WSP L S L +V D + Sbjct: 188 KYNSDAQTYVLESTL------EGHSDWVRDVAWSPTVLLRSYLASVSQDRTCI 234 >5I2T-A nrPDB Length = 742 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 22/73 (30%), Positives = 38/73 (52%), Gaps = 1/73 (1%) Query: 124 HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVF 183 H D ++++ G++ V+ S+D IKVWD+ L+++ H + VT V + + V Sbjct: 369 HFDSTNSLAYSPDGSRVVTASEDGKIKVWDITSGFCLATFEEHTSSVTAVQFAK-RGQVM 427 Query: 184 LSCSEDNRILLWD 196 S S D + WD Sbjct: 428 FSSSLDGTVRAWD 440 Score = 35.0 bits (79), Expect = 0.050, Method: Compositional matrix adjust. Identities = 26/106 (24%), Positives = 44/106 (41%), Gaps = 11/106 (10%) Query: 94 ILVASDSGAVELWELDENETLIVSKFC---KYEHDDIVSTVSVLSSGTQAVSGSKDICIK 150 ++ AS+ G +++W+ I S FC EH V+ V G S S D ++ Sbjct: 385 VVTASEDGKIKVWD-------ITSGFCLATFEEHTSSVTAVQFAKRGQVMFSSSLDGTVR 437 Query: 151 VWDLAQQVVLSSYRA-HAAQVTCVAASPHKDSVFLSCSEDNRILLW 195 WDL + ++ Q C+A P + V ++ I +W Sbjct: 438 AWDLIRYRNFRTFTGTERIQFNCLAVDPSGEVVCAGSLDNFDIHVW 483 >5MZH-A nrPDB Length = 452 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 41/184 (22%), Positives = 81/184 (44%), Gaps = 7/184 (3%) Query: 124 HDDIVSTVSVLS-SGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSV 182 H ++V ++ + G + V+GS D K+WD + + + H ++ C++ +P + ++ Sbjct: 135 HKNVVYAIAFNNPYGDKIVTGSFDKTCKLWDAYTGQLYYTLKGHQTEIVCLSFNP-QSTI 193 Query: 183 FLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDT 242 + S DN LWD + + + + SL ++ ++ V G + L D Sbjct: 194 IATGSMDNTAKLWDVETGQERATLAGHRAEIV--SLGFNT-GGDLIVTGSFDHDSRLWDV 250 Query: 243 KSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSE-LFRSQAHRDFVR 301 ++ CV + H V+ F+ ++ + S S DC+ + D L Q H D V Sbjct: 251 RTGQCVHVLSGHRGEVSSTQFN-YAGTLVVSGSIDCTSRLWDVRSGRCLSVKQGHTDEVL 309 Query: 302 DATW 305 D + Sbjct: 310 DVAF 313 Score = 33.5 bits (75), Expect = 0.15, Method: Compositional matrix adjust. Identities = 30/108 (27%), Positives = 51/108 (47%), Gaps = 11/108 (10%) Query: 93 GILVASDSGAVE----LWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDIC 148 G LV S G+++ LW++ L V K H D V V+ ++GT+ VS S D Sbjct: 275 GTLVVS--GSIDCTSRLWDVRSGRCLSV----KQGHTDEVLDVAFDAAGTKMVSASADGS 328 Query: 149 IKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWD 196 +++ V + H +++ VA +P + + ++ S D LWD Sbjct: 329 ARLYHTLTGVCQHTLVGHEGEISKVAFNP-QGTRLITASSDKTCRLWD 375 Score = 29.6 bits (65), Expect = 1.8, Method: Compositional matrix adjust. Identities = 32/133 (24%), Positives = 57/133 (42%), Gaps = 9/133 (6%) Query: 135 SSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVA-ASPHKDSVFLSCSEDNRIL 193 SG + ++GS D KVW+ + + H V +A +P+ D + ++ S D Sbjct: 104 KSGDRFITGSYDRTCKVWNTFTGEEVFTLEGHKNVVYAIAFNNPYGDKI-VTGSFDKTCK 162 Query: 194 LWDTRCPKPASQIGCSAPGYLP--TSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSS 251 LWD Q+ + G+ L+++P QS + G + T L D ++ + Sbjct: 163 LWDAY----TGQLYYTLKGHQTEIVCLSFNP-QSTIIATGSMDNTAKLWDVETGQERATL 217 Query: 252 AVHSQCVTGLVFS 264 A H + L F+ Sbjct: 218 AGHRAEIVSLGFN 230 Score = 29.6 bits (65), Expect = 2.1, Method: Compositional matrix adjust. Identities = 17/72 (23%), Positives = 33/72 (45%), Gaps = 1/72 (1%) Query: 124 HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVF 183 H+ +S V+ GT+ ++ S D ++WD L H ++ A + D + Sbjct: 346 HEGEISKVAFNPQGTRLITASSDKTCRLWDCDTGECLQVLEGHTDEIFSCAFNYEGDFI- 404 Query: 184 LSCSEDNRILLW 195 ++ S+DN +W Sbjct: 405 ITGSKDNTCRIW 416 Score = 28.9 bits (63), Expect = 3.4, Method: Compositional matrix adjust. Identities = 23/74 (31%), Positives = 33/74 (44%), Gaps = 1/74 (1%) Query: 124 HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVF 183 H VS+ +GT VSGS D ++WD+ LS + H +V VA + Sbjct: 262 HRGEVSSTQFNYAGTLVVSGSIDCTSRLWDVRSGRCLSVKQGHTDEVLDVAFDA-AGTKM 320 Query: 184 LSCSEDNRILLWDT 197 +S S D L+ T Sbjct: 321 VSASADGSARLYHT 334 >5WLC-LO nrPDB Length = 923 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 22/73 (30%), Positives = 38/73 (52%), Gaps = 1/73 (1%) Query: 124 HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVF 183 H D ++++ G++ V+ S+D IKVWD+ L+++ H + VT V + + V Sbjct: 344 HFDSTNSLAYSPDGSRVVTASEDGKIKVWDITSGFCLATFEEHTSSVTAVQFAK-RGQVM 402 Query: 184 LSCSEDNRILLWD 196 S S D + WD Sbjct: 403 FSSSLDGTVRAWD 415 Score = 34.7 bits (78), Expect = 0.062, Method: Compositional matrix adjust. Identities = 26/106 (24%), Positives = 44/106 (41%), Gaps = 11/106 (10%) Query: 94 ILVASDSGAVELWELDENETLIVSKFCK---YEHDDIVSTVSVLSSGTQAVSGSKDICIK 150 ++ AS+ G +++W+ I S FC EH V+ V G S S D ++ Sbjct: 360 VVTASEDGKIKVWD-------ITSGFCLATFEEHTSSVTAVQFAKRGQVMFSSSLDGTVR 412 Query: 151 VWDLAQQVVLSSYRA-HAAQVTCVAASPHKDSVFLSCSEDNRILLW 195 WDL + ++ Q C+A P + V ++ I +W Sbjct: 413 AWDLIRYRNFRTFTGTERIQFNCLAVDPSGEVVCAGSLDNFDIHVW 458 >6E29-D nrPDB Length = 345 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 30/121 (24%), Positives = 48/121 (39%), Gaps = 1/121 (0%) Query: 131 VSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDN 190 V G SG D + +WDL V R H+ +T ++ S LS + Sbjct: 31 VRFNRKGDFLASGRVDGTVVIWDLETMGVARKLRGHSKNITSLSWS-RCGRYLLSACQGW 89 Query: 191 RILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLS 250 +++LWD + K ++ AP Y W+ Q +F D+ V + + VL Sbjct: 90 KVILWDLQDGKRYREVRFRAPVYGAELHPWNHHQFAAALFEDQPMLVDITEPVEVRYVLP 149 Query: 251 S 251 S Sbjct: 150 S 150 >3JB9-L nrPDB Length = 340 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 32/141 (22%), Positives = 58/141 (41%), Gaps = 5/141 (3%) Query: 144 SKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPA 203 S D + WD + ++ HA V + + S S+D + +WD+R Sbjct: 112 SSDTHLMSWDAVSGQKIRKHKGHAGVVNALDVLKVGSELLTSVSDDCTMKVWDSRSKDCI 171 Query: 204 SQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVF 263 I Y T++A Q ++VF+ G +G + + D ++ C H +T L Sbjct: 172 KTI---EEKYPLTAVAIAQQGTQVFI-GGIDGAIKIWDLRNNHCSHVLKGHKDIITSLAI 227 Query: 264 SPHSVPFLASLSEDCSLAVLD 284 S L++ S D ++ + D Sbjct: 228 SKDGSSLLSN-SMDNTVRIFD 247 Score = 38.1 bits (87), Expect = 0.006, Method: Compositional matrix adjust. Identities = 34/124 (27%), Positives = 57/124 (45%), Gaps = 9/124 (7%) Query: 78 QTEAGVA---DLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVL 134 + AGV D+ VG + SD +++W+ ++ I + KY ++ V++ Sbjct: 132 KGHAGVVNALDVLKVGSELLTSVSDDCTMKVWD-SRSKDCIKTIEEKYP----LTAVAIA 186 Query: 135 SSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILL 194 GTQ G D IK+WDL + H +T +A S S+ LS S DN + + Sbjct: 187 QQGTQVFIGGIDGAIKIWDLRNNHCSHVLKGHKDIITSLAISKDGSSL-LSNSMDNTVRI 245 Query: 195 WDTR 198 +D + Sbjct: 246 FDVK 249 Score = 30.4 bits (67), Expect = 1.0, Method: Compositional matrix adjust. Identities = 31/121 (25%), Positives = 45/121 (37%), Gaps = 3/121 (2%) Query: 165 AHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQ 224 H A+V P S F S D +ILLW+ + G + T L W Sbjct: 48 GHTAEVLVARFDP-SGSYFASGGMDRQILLWNVFGDVKNYGVLNGCKGAI-TDLQWSRDS 105 Query: 225 SEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLD 284 V+ + +S D S + H+ V L L S+S+DC++ V D Sbjct: 106 RVVYCSSSDTHLMSW-DAVSGQKIRKHKGHAGVVNALDVLKVGSELLTSVSDDCTMKVWD 164 Query: 285 S 285 S Sbjct: 165 S 165 >4BTS-AR nrPDB Length = 343 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 24/93 (25%), Positives = 43/93 (46%), Gaps = 1/93 (1%) Query: 104 ELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSY 163 +L+E ++N + H+ VS +++ A+S S D +++WDL + Sbjct: 55 KLYEEEQNGYFGIPHKALTGHNHFVSDLALSQENCFAISSSWDKTLRLWDLRTGTTYKRF 114 Query: 164 RAHAAQVTCVAASPHKDSVFLSCSEDNRILLWD 196 H ++V VA SP + LS + I LW+ Sbjct: 115 VGHQSEVYSVAFSPDNRQI-LSAGAEREIKLWN 146 Score = 38.9 bits (89), Expect = 0.003, Method: Compositional matrix adjust. Identities = 57/231 (24%), Positives = 99/231 (42%), Gaps = 37/231 (16%) Query: 113 TLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQ-------VVLSSYRA 165 T IV+ F + E++D VL +SGS+D + +W L ++ + + Sbjct: 25 TSIVAGFSQKENED----SPVL------ISGSRDKTVMIWKLYEEEQNGYFGIPHKALTG 74 Query: 166 HAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQ-IGCSAPGYLPTSLAWHPQQ 224 H V+ +A S ++ +S S D + LWD R + +G + Y S+A+ P Sbjct: 75 HNHFVSDLALS-QENCFAISSSWDKTLRLWDLRTGTTYKRFVGHQSEVY---SVAFSPDN 130 Query: 225 SEVFVFGDENGTVSLVDTKSTSCVLSSA---VHSQCVTGLVFSPHS---------VPFLA 272 ++ G E + L + C SSA HS V+ + +SP P+ A Sbjct: 131 RQILSAGAER-EIKLWNILG-ECKFSSAEKENHSDWVSCVRYSPIMKSANKVQPFAPYFA 188 Query: 273 SLSEDCSLAVLDSSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQVV 323 S+ D L V +++ + +AH V + SP N + T G D +++ Sbjct: 189 SVGWDGRLKVWNTNFQIRYTFKAHESNVNHLSISP-NGKYIATGGKDKKLL 238 >6QX9-4B nrPDB Length = 522 Score = 40.0 bits (92), Expect = 0.001, Method: Compositional matrix adjust. Identities = 45/194 (23%), Positives = 81/194 (41%), Gaps = 8/194 (4%) Query: 129 STVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSE 188 STVS+ S + D +K+W L ++ H +V V P + +C Sbjct: 285 STVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCY- 343 Query: 189 DNRILLWDTRCPKPA-SQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSC 247 D LWD + Q G S Y +A+H Q + G + + D ++ C Sbjct: 344 DRSWRLWDLEAQEEILHQEGHSMGVY---DIAFH-QDGSLAGTGGLDAFGRVWDLRTGRC 399 Query: 248 VLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSE-LFRSQAHRDFVRDATWS 306 ++ H + + G+ FSP+ +A+ S D + V D ++ AH++ V + Sbjct: 400 IMFLEGHLKEIYGINFSPNGY-HIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFE 458 Query: 307 PLNHSLLTTVGWDH 320 P++ + L T +D+ Sbjct: 459 PIHGNFLLTGAYDN 472 Score = 37.7 bits (86), Expect = 0.007, Method: Compositional matrix adjust. Identities = 21/72 (29%), Positives = 33/72 (45%) Query: 124 HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVF 183 H + ++ +G +GS D KVWDL Q+ + + AH VT V P + Sbjct: 406 HLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFL 465 Query: 184 LSCSEDNRILLW 195 L+ + DN +W Sbjct: 466 LTGAYDNTAKIW 477 Score = 35.4 bits (80), Expect = 0.038, Method: Compositional matrix adjust. Identities = 44/185 (23%), Positives = 75/185 (40%), Gaps = 14/185 (7%) Query: 101 GAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVL 160 G+V+LW LD +E + + H V+ V SG + D ++WDL Q + Sbjct: 303 GSVKLWSLDSDEPVADIE----GHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEI 358 Query: 161 SSYRAHAAQVTCVAASPHKD-SVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPT--S 217 H+ V +A H+D S+ + D +WD R + + G+L Sbjct: 359 LHQEGHSMGVYDIAF--HQDGSLAGTGGLDAFGRVWDLRTGRCIMFL----EGHLKEIYG 412 Query: 218 LAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSED 277 + + P + G + T + D + CV + H VTG+ F P FL + + D Sbjct: 413 INFSPNGYHIAT-GSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYD 471 Query: 278 CSLAV 282 + + Sbjct: 472 NTAKI 476 >6MZM-G nrPDB Length = 800 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 44/165 (26%), Positives = 65/165 (39%), Gaps = 9/165 (5%) Query: 122 YEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDS 181 Y H V S +S S+D +++W L L Y+ H V SP+ Sbjct: 540 YGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPY-GY 598 Query: 182 VFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLP--TSLAWHPQQSEVFVFGDENGTVSL 239 F+S D LW T +P G+L +HP + V G + TV L Sbjct: 599 YFVSGGHDRVARLWATDHYQPLRIFA----GHLADVNCTRFHPNSNYV-ATGSADRTVRL 653 Query: 240 VDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLD 284 D + +CV H + L FSP+ FLA+ + D + + D Sbjct: 654 WDVLNGNCVRIFTGHKGPIHSLTFSPNG-RFLATGATDGRVLLWD 697 >5NNZ-B nrPDB Length = 415 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 33/178 (18%), Positives = 77/178 (43%), Gaps = 6/178 (3%) Query: 138 TQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDT 197 T +GS D K+WD+ + + R H+A++ ++ + D + ++ S D+ +++WD Sbjct: 190 TLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRI-ITGSFDHTVVVWDA 248 Query: 198 RCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQC 257 + + + S W + + G + T L D + CV + H Sbjct: 249 DTGRKVNILIGHCAEISSASFNW---DCSLILTGSMDKTCKLWDATNGKCVATLTGHDDE 305 Query: 258 VTGLVFSPHSVPFLASLSEDCSLAVLDSSLSE-LFRSQAHRDFVRDATWSPLNHSLLT 314 + F ++ +A+ S D + + ++ + + + + H + +++P + LLT Sbjct: 306 ILDSCF-DYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLT 362 Score = 33.1 bits (74), Expect = 0.16, Method: Compositional matrix adjust. Identities = 17/72 (23%), Positives = 34/72 (47%), Gaps = 1/72 (1%) Query: 124 HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVF 183 H+ +S +S G ++GS D ++WD L H ++ A + +K ++ Sbjct: 344 HEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFN-YKGNIV 402 Query: 184 LSCSEDNRILLW 195 ++ S+DN +W Sbjct: 403 ITGSKDNTCRIW 414 Score = 32.3 bits (72), Expect = 0.30, Method: Compositional matrix adjust. Identities = 41/158 (25%), Positives = 69/158 (43%), Gaps = 8/158 (5%) Query: 109 DENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAA 168 + N T + K K H ++ V++ SG+ ++GS D K+WD A L++ H Sbjct: 77 NSNHTFYLFKVLK-AHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRN 135 Query: 169 QVTCVA-ASPHKDSVFLSCSEDNRILLWDTRCPKPASQI-GCSAPGYLPTSLAWHPQQSE 226 V +A +P+ D + + S D LW K G +A L+++P QS Sbjct: 136 VVYAIAFNNPYGDKI-ATGSFDKTCKLWSVETGKCYHTFRGHTAE---IVCLSFNP-QST 190 Query: 227 VFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFS 264 + G + T L D ++ V + HS + L F+ Sbjct: 191 LVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFN 228 >5L9T-R nrPDB Length = 493 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 40/159 (25%), Positives = 61/159 (38%), Gaps = 5/159 (3%) Query: 116 VSKFCKYE-HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVA 174 V++ C D V++V G G+ +++WD A LS H A+V +A Sbjct: 219 VTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALA 278 Query: 175 ASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDEN 234 + + S S S D IL D R P S+ L W ++ G + Sbjct: 279 WNAEQLS---SGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDH-QLLASGGND 334 Query: 235 GTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLAS 273 + + + S S V H V + +SPH LAS Sbjct: 335 NKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLAS 373 Score = 37.4 bits (85), Expect = 0.010, Method: Compositional matrix adjust. Identities = 35/127 (27%), Positives = 51/127 (40%), Gaps = 6/127 (4%) Query: 142 SGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLS--CSEDNRILLWDTRC 199 SG D + VW+ + + Y H A V +A SPH+ + S + D I W+T Sbjct: 330 SGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLT 389 Query: 200 PKPASQIGCSAPGYLPTSLAWHPQQSE-VFVFGDENGTVSLVDTKSTSCVLSSAVHSQCV 258 +P + C G +LAW +E V G + + S + V HS V Sbjct: 390 GQP---LQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRV 446 Query: 259 TGLVFSP 265 L SP Sbjct: 447 LYLAMSP 453 >6F3T-A nrPDB Length = 608 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 44/165 (26%), Positives = 65/165 (39%), Gaps = 9/165 (5%) Query: 122 YEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDS 181 Y H V S +S S+D +++W L L Y+ H V SP+ Sbjct: 348 YGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYG-Y 406 Query: 182 VFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLP--TSLAWHPQQSEVFVFGDENGTVSL 239 F+S D LW T +P G+L +HP + V G + TV L Sbjct: 407 YFVSGGHDRVARLWATDHYQPLRIFA----GHLADVNCTRFHPNSNYV-ATGSADRTVRL 461 Query: 240 VDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLD 284 D + +CV H + L FSP+ FLA+ + D + + D Sbjct: 462 WDVLNGNCVRIFTGHKGPIHSLTFSPNG-RFLATGATDGRVLLWD 505 >5Y88-O nrPDB Length = 451 Score = 39.3 bits (90), Expect = 0.002, Method: Compositional matrix adjust. Identities = 39/158 (24%), Positives = 68/158 (43%), Gaps = 9/158 (5%) Query: 141 VSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCP 200 ++GS D +KVWDLA + ++ H V VA S +F S SED + WD Sbjct: 156 ITGSNDTTMKVWDLATGKLKTTLAGHVMTVRDVAVSDRHPYLF-SVSEDKTVKCWDLE-- 212 Query: 201 KPASQIGCSAPGYLP--TSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCV 258 +QI G+L +++ HP + G + + L D ++ V++ H + Sbjct: 213 --KNQIIRDYYGHLSGVRTVSIHPTLDLIATAG-RDSVIKLWDMRTRIPVITLVGHKGPI 269 Query: 259 TGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQAH 296 + +P P + S S D ++ + D + + H Sbjct: 270 NQVQCTPVD-PQVVSSSTDATVRLWDVVAGKTMKVLTH 306 Score = 38.9 bits (89), Expect = 0.003, Method: Compositional matrix adjust. Identities = 46/203 (22%), Positives = 77/203 (37%), Gaps = 11/203 (5%) Query: 94 ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWD 153 + S+ +++W+L + K H V V+V S S+D +K WD Sbjct: 155 FITGSNDTTMKVWDLATGKL----KTTLAGHVMTVRDVAVSDRHPYLFSVSEDKTVKCWD 210 Query: 154 LAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPA-SQIGCSAPG 212 L + ++ Y H + V V+ P D + + D+ I LWD R P + +G P Sbjct: 211 LEKNQIIRDYYGHLSGVRTVSIHPTLD-LIATAGRDSVIKLWDMRTRIPVITLVGHKGPI 269 Query: 213 YLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLA 272 PQ V + TV L D + + H + V P + Sbjct: 270 NQVQCTPVDPQ----VVSSSTDATVRLWDVVAGKTMKVLTHHKRSVRATALHPKEFSVAS 325 Query: 273 SLSEDC-SLAVLDSSLSELFRSQ 294 + ++D S + + SL F S+ Sbjct: 326 ACTDDIRSWGLAEGSLLTNFESE 348 Score = 37.7 bits (86), Expect = 0.008, Method: Compositional matrix adjust. Identities = 28/106 (26%), Positives = 42/106 (39%), Gaps = 5/106 (4%) Query: 139 QAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTR 198 Q VS S D +++WD+ + H V A P + SV +C++D I W Sbjct: 280 QVVSSSTDATVRLWDVVAGKTMKVLTHHKRSVRATALHPKEFSVASACTDD--IRSWGLA 337 Query: 199 CPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKS 244 + G + T Q +V G +NG +S D KS Sbjct: 338 EGSLLTNFESEKTGIINT---LSINQDDVLFAGGDNGVLSFYDYKS 380 Score = 28.9 bits (63), Expect = 3.2, Method: Compositional matrix adjust. Identities = 20/70 (28%), Positives = 29/70 (41%), Gaps = 17/70 (24%) Query: 152 WDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAP 211 W L++ + H V CVA P + F++ S D + +WD A Sbjct: 129 WKLSRVI-----NGHLGWVRCVAIDPVDNEWFITGSNDTTMKVWDL------------AT 171 Query: 212 GYLPTSLAWH 221 G L T+LA H Sbjct: 172 GKLKTTLAGH 181 >5OQL-L nrPDB Length = 557 Score = 39.3 bits (90), Expect = 0.002, Method: Compositional matrix adjust. Identities = 43/193 (22%), Positives = 81/193 (41%), Gaps = 25/193 (12%) Query: 103 VELWELDENETL-IVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQ---QV 158 VE++ + + E L + +F H + G V+G ++V+D+ Q V Sbjct: 81 VEIFSIRKREPLKTIGRFDSEAH-----CGEIRPDGRVLVAGEDTGRMQVFDVGQGTRAV 135 Query: 159 VLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKP-------ASQIGCSAP 211 +L ++ H V SP + + +SCS+D + LWD P + C A Sbjct: 136 ILKTWHIHKQPVWVTKWSPTELTTLMSCSDDKTVRLWDLPSNDPTRLFTGHTDYVRCGA- 194 Query: 212 GYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFL 271 ++P S S + V G + TV + D ++ + + H+ + ++ P L Sbjct: 195 -FMPGS-----ANSNLLVSGSYDETVRVWDARAPGGAVMTFKHADPIEDVLPLPSGTTLL 248 Query: 272 ASLSEDCSLAVLD 284 A + +++VLD Sbjct: 249 A--ASGNAISVLD 259 Score = 28.9 bits (63), Expect = 3.1, Method: Compositional matrix adjust. Identities = 21/82 (25%), Positives = 38/82 (46%), Gaps = 2/82 (2%) Query: 123 EHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVL--SSYRAHAAQVTCVAASPHKD 180 H V+++S+ S G + VSGS D +KV++ V+ + Y + ++ + A D Sbjct: 271 NHQKTVTSLSLASQGRRVVSGSLDGHVKVFETTSWNVVAGAKYPSPILSLSVITAGASHD 330 Query: 181 SVFLSCSEDNRILLWDTRCPKP 202 L+ + +L TR P Sbjct: 331 DRHLAVGMQSGVLSIRTRLSGP 352 >3JRO-A nrPDB Length = 753 Score = 39.3 bits (90), Expect = 0.002, Method: Compositional matrix adjust. Identities = 54/230 (23%), Positives = 97/230 (42%), Gaps = 41/230 (17%) Query: 124 HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQV--VLSSYRAHAAQVTCVA-ASPHKD 180 H++++ + G + + S D IK++++ + ++ + H V V A P Sbjct: 8 HNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFG 67 Query: 181 SVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLP-TSLAWHPQQ-SEVFVFGDENGTVS 238 ++ SCS D ++L+W + SQI A S+ W P + + + +G VS Sbjct: 68 TILASCSYDGKVLIWKEENGR-WSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVS 126 Query: 239 LVDTK---STSCVLSSAVHSQCVTGLVFSPHSV-------------PFLA---------- 272 +V+ K +TS ++ A H+ V ++P ++ F+ Sbjct: 127 VVEFKENGTTSPIIIDA-HAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIW 185 Query: 273 SLSEDCSLAVLDSSLSELFRSQAHRDFVRDATWSP--LNHSLLTTVGWDH 320 + D VL+S+L + H D+VRD WSP L S L +V D Sbjct: 186 KYNSDAQTYVLESTL------EGHSDWVRDVAWSPTVLLRSYLASVSQDR 229 >6HHQ-h nrPDB Length = 319 Score = 39.3 bits (90), Expect = 0.003, Method: Compositional matrix adjust. Identities = 26/107 (24%), Positives = 46/107 (42%), Gaps = 10/107 (9%) Query: 124 HDDIVSTVSVL------SSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASP 177 H+D VS V V+ +S D +K W+L Q + + + H + + + ASP Sbjct: 147 HNDWVSQVRVVPNEKADDDSVTIISAGNDKMVKAWNLNQFQIEADFIGHNSNINTLTASP 206 Query: 178 HKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQ 224 ++ S +D I+LW+ K + + SLA+ P + Sbjct: 207 DG-TLIASAGKDGEIMLWNLAAKKAMYTLSAQDEVF---SLAFSPNR 249 Score = 37.0 bits (84), Expect = 0.011, Method: Compositional matrix adjust. Identities = 31/117 (26%), Positives = 53/117 (45%), Gaps = 6/117 (5%) Query: 94 ILVASDSGAVELWEL---DENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIK 150 +L AS + W+L D+ + V F + H IV ++ + G A+S S D ++ Sbjct: 33 LLSASRDKTLISWKLTGDDQKFGVPVRSFKGHSH--IVQDCTLTADGAYALSASWDKTLR 90 Query: 151 VWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIG 207 +WD+A + H + V V K S+ +S S D I +W + A+ +G Sbjct: 91 LWDVATGETYQRFVGHKSDVMSVDIDK-KASMIISGSRDKTIKVWTIKGQCLATLLG 146 Score = 30.8 bits (68), Expect = 0.78, Method: Compositional matrix adjust. Identities = 24/86 (27%), Positives = 43/86 (50%), Gaps = 5/86 (5%) Query: 94 ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWD 153 I+ A + V+ W L N+ I + F H+ ++T++ GT S KD I +W+ Sbjct: 169 IISAGNDKMVKAWNL--NQFQIEADFIG--HNSNINTLTASPDGTLIASAGKDGEIMLWN 224 Query: 154 LAQQVVLSSYRAHAAQVTCVAASPHK 179 LA + + + A +V +A SP++ Sbjct: 225 LAAKKAMYTLSAQ-DEVFSLAFSPNR 249 >6Q8F-A nrPDB Length = 514 Score = 38.9 bits (89), Expect = 0.004, Method: Compositional matrix adjust. Identities = 38/162 (23%), Positives = 65/162 (40%), Gaps = 15/162 (9%) Query: 94 ILVASDSGAVELWELDENETLIVSKFCKYE-------HDDIVSTVSVLSSGTQAVSGSKD 146 ++ S G +E+W + + K KY+ DD V + +G++D Sbjct: 230 LVTGSVDGFIEVWNFTTGK---IRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQD 286 Query: 147 ICIKVWDLAQQVVLSSY-RAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQ 205 IKVW + L + RAH+ VTC++ S + LS S D I + + K + Sbjct: 287 GKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQI-LSASFDQTIRIHGLKSGKTLKE 345 Query: 206 IGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSC 247 + + A Q + +GTV + + K+T C Sbjct: 346 FRGHSS---FVNEATFTQDGHYIISASSDGTVKIWNMKTTEC 384 Score = 32.3 bits (72), Expect = 0.33, Method: Compositional matrix adjust. Identities = 40/195 (20%), Positives = 76/195 (38%), Gaps = 12/195 (6%) Query: 94 ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWD 153 IL AS + + L +TL +F H V+ + G +S S D +K+W+ Sbjct: 323 ILSASFDQTIRIHGLKSGKTL--KEF--RGHSSFVNEATFTQDGHYIISASSDGTVKIWN 378 Query: 154 LAQQVVLSSYRAHAA------QVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIG 207 + +++++ + V V P F+ C+ N +++ + + S Sbjct: 379 MKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSS 438 Query: 208 CSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHS 267 G A P+ ++ G E+ + T + + VH + V G+ PH Sbjct: 439 GKREGGDFVCCALSPRGEWIYCVG-EDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQ 497 Query: 268 VPFLASLSEDCSLAV 282 +A+ SED L + Sbjct: 498 -NLIATYSEDGLLKL 511 >2PM9-A nrPDB Length = 416 Score = 38.5 bits (88), Expect = 0.004, Method: Compositional matrix adjust. Identities = 39/166 (23%), Positives = 68/166 (40%), Gaps = 15/166 (9%) Query: 75 AGVQTEAGVADLTWVGERGILVAS-DSGAVELWELDENETLIVSKFCKYEHDDIVSTVSV 133 A +Q ++ DL W I+ + D+G++EL+ +E I S H V TV Sbjct: 62 ASLQVDSKFNDLDWSHNNKIIAGALDNGSLELYSTNEANNAINSMARFSNHSSSVKTVKF 121 Query: 134 LSSGTQAV-SGSKDICIKVWDLAQ-QVVLSSY--------RAHAAQVTCVAASPHKDSVF 183 + + SG + I +WD+ + S+Y + +V +A + VF Sbjct: 122 NAKQDNVLASGGNNGEIFIWDMNKCTESPSNYTPLTPGQSMSSVDEVISLAWNQSLAHVF 181 Query: 184 LSCSEDNRILLWDTRCPKPASQIGCSAPGY-LPTSLA---WHPQQS 225 S N +WD + K + ++P + L+ WHP+ S Sbjct: 182 ASAGSSNFASIWDLKAKKEVIHLSYTSPNSGIKQQLSVVEWHPKNS 227 Score = 28.1 bits (61), Expect = 5.5, Method: Compositional matrix adjust. Identities = 21/91 (23%), Positives = 35/91 (38%), Gaps = 4/91 (4%) Query: 140 AVSGSKDICIKVWDL--AQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDT 197 A D I +WDL A + + + H + + + + LS DN +LLW+ Sbjct: 233 ATGSDNDPSILIWDLRNANTPLQTLNQGHQKGILSLDWCHQDEHLLLSSGRDNTVLLWNP 292 Query: 198 RCPKPASQIGCSAPGYLPTSLAWHPQQSEVF 228 + SQ T A P+ ++F Sbjct: 293 ESAEQLSQFPARGNWCFKTKFA--PEAPDLF 321 >3W15-A nrPDB Length = 368 Score = 38.1 bits (87), Expect = 0.006, Method: Compositional matrix adjust. Identities = 60/286 (20%), Positives = 106/286 (37%), Gaps = 60/286 (20%) Query: 79 TEAGVADLTW--VGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSS 136 T+ + DL W E +LVA G + L++ E ++ F ++E + + S L + Sbjct: 61 TQDCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKE-FPIAIFKEHERE-VFSCNWNLVN 118 Query: 137 GTQAVSGSKDICIKVWD-LAQQVVLS-----------------------SYRAHAAQVTC 172 +S S D IK+W L +Q +++ S+ + C Sbjct: 119 RQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNC 178 Query: 173 VAA---SPHKDSVFLSCSEDNRILLWDTRCPKPASQ-----------IGCSAPGYLPTSL 218 V SPH ++ LSCS ++ L+D R P +Q + C Y P + Sbjct: 179 VYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVV 238 Query: 219 AWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSS-AVHSQCVTGLVFSPHSVPFLASLSED 277 A + + ++ + ++SC+ H + + +SPH L S S D Sbjct: 239 ATGGVDNAIRIWDIRMLNKNPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYD 298 Query: 278 CSLAV-----------------LDSSLSELFRSQAHRDFVRDATWS 306 + + D++ +F H +FV A WS Sbjct: 299 MTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWS 344 >4A11-B nrPDB Length = 408 Score = 38.1 bits (87), Expect = 0.006, Method: Compositional matrix adjust. Identities = 42/163 (25%), Positives = 58/163 (35%), Gaps = 18/163 (11%) Query: 137 GTQAVSGSKDICIKVWDLAQQVVLSSYR-------------AHAAQVTCVAASPHKDSVF 183 G +SG D I ++DL S Y H V V PH +F Sbjct: 56 GRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMF 115 Query: 184 LSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSE--VFVFGDENGTVSLVD 241 S S D + +WDT + A Y S P ++ + G V L D Sbjct: 116 TSSSFDKTLKVWDTNTLQTADVFNFEETVY---SHHMSPVSTKHCLVAVGTRGPKVQLCD 172 Query: 242 TKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLD 284 KS SC H Q + + +SP LA+ S D + + D Sbjct: 173 LKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWD 215 Score = 32.0 bits (71), Expect = 0.38, Method: Compositional matrix adjust. Identities = 38/175 (21%), Positives = 64/175 (36%), Gaps = 19/175 (10%) Query: 164 RAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSA-----------PG 212 R H + + P + LS D I+L+D S C A Sbjct: 40 RIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHR 99 Query: 213 YLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCV----LSSAVHSQCVTGLVFSPHSV 268 Y ++ W+P + +F + T+ + DT + V+S ++ V + H + Sbjct: 100 YSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSP-VSTKHCL 158 Query: 269 PFLASLSEDCSLAVLDS-SLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQV 322 + + L L S S S + Q HR + +WSP +L T D +V Sbjct: 159 VAVGTRGPKVQLCDLKSGSCSHIL--QGHRQEILAVSWSPRYDYILATASADSRV 211 Score = 32.0 bits (71), Expect = 0.44, Method: Compositional matrix adjust. Identities = 15/56 (26%), Positives = 28/56 (50%) Query: 143 GSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTR 198 G++ +++ DL + H ++ V+ SP D + + S D+R+ LWD R Sbjct: 162 GTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVR 217 >5OQL-d nrPDB Length = 446 Score = 37.7 bits (86), Expect = 0.008, Method: Compositional matrix adjust. Identities = 52/220 (23%), Positives = 80/220 (36%), Gaps = 50/220 (22%) Query: 142 SGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWD-TRCP 200 SGS D +KVWDL + ++R A + D LSC+ D I LWD P Sbjct: 84 SGSGDGVVKVWDLTTRDE-ETWRVAAHNNIVKGLTFTNDKKLLSCATDG-IKLWDPYASP 141 Query: 201 KPASQIGCSAPGYLPTSLAWHP-------------------------------------- 222 + I G TSL++H Sbjct: 142 SNTTPIATWQEGGPYTSLSFHRSANTFAASSGQGCIRIWDLEHSTAGQAIQWPSFVDTIT 201 Query: 223 ----QQSEVFVFGD--ENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSE 276 Q E V G + ++ L D ++ V+ + +H C +VF+P LA SE Sbjct: 202 DVCFNQVETSVIGSVATDRSIILFDLRTNMPVIKTVLHFAC-NRIVFNPMEAMNLAVASE 260 Query: 277 DCSLAVLDSSLSE--LFRSQAHRDFVRDATWSPLNHSLLT 314 D ++ + D+ + L + H V D +SP L++ Sbjct: 261 DHNIYIFDARNFDKALNIQKGHVAAVMDVEFSPTGEELVS 300 Score = 32.7 bits (73), Expect = 0.22, Method: Compositional matrix adjust. Identities = 38/189 (20%), Positives = 79/189 (41%), Gaps = 14/189 (7%) Query: 83 VADLTWVGERGILVASDSGAVELWE---LDENETLIVSKFCKYEHDDIVSTVSVLSSGTQ 139 V LT+ ++ +L + G ++LW+ N T I + ++ +++S S Sbjct: 113 VKGLTFTNDKKLLSCATDG-IKLWDPYASPSNTTPIAT----WQEGGPYTSLSFHRSANT 167 Query: 140 AVSGSKDICIKVWDLAQQVVLSSYR--AHAAQVTCVAASPHKDSVFLSCSEDNRILLWDT 197 + S CI++WDL + + + +T V + + SV S + D I+L+D Sbjct: 168 FAASSGQGCIRIWDLEHSTAGQAIQWPSFVDTITDVCFNQVETSVIGSVATDRSIILFDL 227 Query: 198 RCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLS-SAVHSQ 256 R P + + + + ++P ++ E+ + + D ++ L+ H Sbjct: 228 RTNMPVIK---TVLHFACNRIVFNPMEAMNLAVASEDHNIYIFDARNFDKALNIQKGHVA 284 Query: 257 CVTGLVFSP 265 V + FSP Sbjct: 285 AVMDVEFSP 293 >4J0W-A nrPDB Length = 343 Score = 37.4 bits (85), Expect = 0.009, Method: Compositional matrix adjust. Identities = 28/116 (24%), Positives = 50/116 (43%), Gaps = 13/116 (11%) Query: 90 GERGILVASDSGAVELWELDEN---ETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKD 146 G + S +V++W + EN ETL + H D V+ + LS +G +D Sbjct: 120 GTHQLYSTSHDRSVKVWNVAENSYVETL-------FGHQDAVAALDALSRECCVTAGGRD 172 Query: 147 ICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKP 202 ++VW + ++ L Y H + C+ + V S ++D + LW +P Sbjct: 173 GTVRVWKIPEESQLVFY-GHQGSIDCIHLINEEHMV--SGADDGSVALWGLSKKRP 225 Score = 30.4 bits (67), Expect = 1.1, Method: Compositional matrix adjust. Identities = 36/149 (24%), Positives = 59/149 (39%), Gaps = 17/149 (11%) Query: 164 RAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPK-----PASQIGCSA--PGYLPT 216 R H +TC+ +P DS S ++D I+ W + P ++ G PG+ Sbjct: 11 RGHQLSITCLVVTP-DDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSH 69 Query: 217 SLAWH-PQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLS 275 L + GD + + + + +S + + H V+GL F L S S Sbjct: 70 VLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFR-RGTHQLYSTS 128 Query: 276 EDCSLAVL----DSSLSELFRSQAHRDFV 300 D S+ V +S + LF H+D V Sbjct: 129 HDRSVKVWNVAENSYVETLF---GHQDAV 154 Score = 30.0 bits (66), Expect = 1.5, Method: Compositional matrix adjust. Identities = 26/116 (22%), Positives = 49/116 (42%), Gaps = 6/116 (5%) Query: 124 HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVF 183 H D VS ++ Q S S D +KVW++A+ + + H V + A ++ Sbjct: 108 HRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALS-RECCV 166 Query: 184 LSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSL 239 + D + +W + P+ + + G + H E V G ++G+V+L Sbjct: 167 TAGGRDGTVRVW--KIPEESQLVFYGHQGSIDCI---HLINEEHMVSGADDGSVAL 217 >5A9Q-2 nrPDB Length = 326 Score = 37.0 bits (84), Expect = 0.013, Method: Compositional matrix adjust. Identities = 23/111 (20%), Positives = 50/111 (45%), Gaps = 6/111 (5%) Query: 142 SGSKDICIKVW--DLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRC 199 + + D+ I+++ DL + H + + P + S S+D+ +W+ Sbjct: 97 TSAADMKIRLFTSDLQDKNEYKVLEGHTDFINGLVFDPKEGQEIASVSDDHTCRIWNLEG 156 Query: 200 PKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLS 250 + A + +PG S+ WHP+++ + ++NGT+ D + +LS Sbjct: 157 VQTAHFV-LHSPG---MSVCWHPEETFKLMVAEKNGTIRFYDLLAQQAILS 203 >4V7E-Bg nrPDB Length = 380 Score = 36.6 bits (83), Expect = 0.017, Method: Compositional matrix adjust. Identities = 28/112 (25%), Positives = 51/112 (45%), Gaps = 7/112 (6%) Query: 138 TQAVSGSKDICIKVWDLAQQVVLSSY-----RAHAAQVTCVAASPHKDSVFLSCSEDNRI 192 T+ ++GS D +WD+ +S + H A V ++ + ++F+S S D + Sbjct: 171 TRLITGSGDQTCVLWDVTTGQRISIFGSEFPSGHTADVLSLSINSLNANMFISGSCDTTV 230 Query: 193 LLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKS 244 LWD R A + G + S+ + P + F G ++GT L D ++ Sbjct: 231 RLWDLRITSRAVRTYHGHEGDI-NSVKFFP-DGQRFGTGSDDGTCRLFDMRT 280 Score = 30.4 bits (67), Expect = 1.1, Method: Compositional matrix adjust. Identities = 25/111 (22%), Positives = 46/111 (41%), Gaps = 4/111 (3%) Query: 91 ERGILVASDSGAVELWELDENETLIV--SKFCKYEHDDIVSTVSVLSSGTQAVSGSKDIC 148 E ++ S LW++ + + + S+F D++S + +SGS D Sbjct: 170 ETRLITGSGDQTCVLWDVTTGQRISIFGSEFPSGHTADVLSLSINSLNANMFISGSCDTT 229 Query: 149 IKVWDLA-QQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTR 198 +++WDL + +Y H + V P F + S+D L+D R Sbjct: 230 VRLWDLRITSRAVRTYHGHEGDINSVKFFPDGQR-FGTGSDDGTCRLFDMR 279 >5A9Q-7 nrPDB Length = 360 Score = 35.4 bits (80), Expect = 0.037, Method: Compositional matrix adjust. Identities = 24/87 (27%), Positives = 41/87 (47%), Gaps = 4/87 (4%) Query: 114 LIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQV---VLSSYRAHAAQV 170 + V++ +H D++ VS G + + S D +KVWD ++ +S++ H+ V Sbjct: 1 MFVARSIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSV 60 Query: 171 TCVA-ASPHKDSVFLSCSEDNRILLWD 196 V A P V SCS D +W+ Sbjct: 61 WRVTWAHPEFGQVLASCSFDRTAAVWE 87 >5CXC-A nrPDB Length = 510 Score = 35.0 bits (79), Expect = 0.046, Method: Compositional matrix adjust. Identities = 19/64 (29%), Positives = 31/64 (48%), Gaps = 5/64 (7%) Query: 162 SYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQI-----GCSAPGYLPT 216 + R HA +V ++ SP + +S S D +WD R +PA++ G S P Y+ Sbjct: 398 TLRGHANKVVSLSPSPENEYSLVSGSHDGTCRVWDLRSVRPATKEEGSLGGVSEPVYVIE 457 Query: 217 SLAW 220 +W Sbjct: 458 RESW 461 Score = 30.8 bits (68), Expect = 0.91, Method: Compositional matrix adjust. Identities = 46/197 (23%), Positives = 76/197 (38%), Gaps = 25/197 (12%) Query: 94 ILVASDSGAVELWELDENETLIVSKFCKYEHDDIV---STVSVLSSGTQAVSGSKDICIK 150 IL AS GA+ W SK E D + + VS T +VS ++ + Sbjct: 255 ILTASADGAIGFWS--------ASKASAPEPDASLLPGAHVSKRRKATSSVSTAQRGPLG 306 Query: 151 VWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSA 210 +W + H A T P +V S S+D+ + D + S + + Sbjct: 307 LWSI-----------HTAPATAAIFDPRDRTVAYSASQDHTVRTLDLTTGQVVSTLTLTH 355 Query: 211 PGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTK---STSCVLSSAVHSQCVTGLVFSPHS 267 P ++L S + G +++VD + +T+ V++ H+ V L SP + Sbjct: 356 PLLSLSALTRAGTTSPLLAAGTSARHITMVDPRASSATTSVMTLRGHANKVVSLSPSPEN 415 Query: 268 VPFLASLSEDCSLAVLD 284 L S S D + V D Sbjct: 416 EYSLVSGSHDGTCRVWD 432 >5A9Q-0 nrPDB Length = 380 Score = 34.7 bits (78), Expect = 0.060, Method: Compositional matrix adjust. Identities = 20/66 (30%), Positives = 34/66 (51%), Gaps = 3/66 (4%) Query: 142 SGSKDICIKVWDLAQQVV-LSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWD--TR 198 +G +D + +WD+ Q + +S +AH A++ V P +CSED + WD T Sbjct: 235 TGGQDGMLSIWDVRQGTMPVSLLKAHEAEMWEVHFHPSNPEHLFTCSEDGSLWHWDASTD 294 Query: 199 CPKPAS 204 P+ +S Sbjct: 295 VPEKSS 300 Score = 28.5 bits (62), Expect = 4.9, Method: Compositional matrix adjust. Identities = 32/143 (22%), Positives = 53/143 (37%), Gaps = 28/143 (19%) Query: 149 IKVWDLAQQ----VVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPAS 204 +K+WD QQ + S + CV P++ V + +D + +WD R Sbjct: 195 LKIWDFRQQGNEPSQILSLTGDRVPLHCVDRHPNQQHVVATGGQDGMLSIWDVR------ 248 Query: 205 QIGCSAPGYLPTSL-----------AWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAV 253 G +P SL +HP E E+G++ D ST S++ Sbjct: 249 ------QGTMPVSLLKAHEAEMWEVHFHPSNPEHLFTCSEDGSLWHWDA-STDVPEKSSL 301 Query: 254 HSQCVTGLVFSPHSVPFLASLSE 276 Q F HS+ A++ + Sbjct: 302 FHQGGRSSTFLSHSISNQANVHQ 324 >4AEZ-A nrPDB Length = 401 Score = 34.3 bits (77), Expect = 0.083, Method: Compositional matrix adjust. Identities = 56/234 (23%), Positives = 97/234 (41%), Gaps = 27/234 (11%) Query: 91 ERGILV-ASDSGAVE-LWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDIC 148 ER + V +DSG+V L E DE T + S K+ HD G+ G + Sbjct: 112 ERNVYVWNADSGSVSALAETDE-STYVAS--VKWSHD-----------GSFLSVGLGNGL 157 Query: 149 IKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGC 208 + ++D+ Q L + H A+V C++ + H V S S I D R QIG Sbjct: 158 VDIYDVESQTKLRTMAGHQARVGCLSWNRH---VLSSGSRSGAIHHHDVRIAN--HQIG- 211 Query: 209 SAPGYLPT--SLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPH 266 + G+ LAW ++ G++N V + D +S+ + H+ V + + P Sbjct: 212 TLQGHSSEVCGLAWRSDGLQLASGGNDN-VVQIWDARSSIPKFTKTNHNAAVKAVAWCPW 270 Query: 267 SVPFLAS--LSEDCSLAVLDSSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGW 318 LA+ + D + +++ + V WSP + +++T G+ Sbjct: 271 QSNLLATGGGTMDKQIHFWNAATGARVNTVDAGSQVTSLIWSPHSKEIMSTHGF 324 >3F3P-A nrPDB Length = 351 Score = 34.3 bits (77), Expect = 0.086, Method: Compositional matrix adjust. Identities = 24/78 (30%), Positives = 36/78 (46%), Gaps = 5/78 (6%) Query: 124 HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQV----VLSSYRAHAAQVTCVA-ASPH 178 HDD+V V G + S D IKV+ L + + S+RAH + + + ASP Sbjct: 10 HDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPE 69 Query: 179 KDSVFLSCSEDNRILLWD 196 + S S D + LW+ Sbjct: 70 YGRIIASASYDKTVKLWE 87 >5OQL-J nrPDB Length = 912 Score = 33.9 bits (76), Expect = 0.10, Method: Compositional matrix adjust. Identities = 19/60 (31%), Positives = 31/60 (51%), Gaps = 8/60 (13%) Query: 143 GSKDICIKVWDLAQQVVLSSY-------RAHAAQVTCVAASPHKDSVFLSCSEDNRILLW 195 G++D I+++DL ++ Y AH + V C+A SP + + LS S D + LW Sbjct: 201 GTQDGRIRIFDLYKRTTTPVYADPKRKKEAHESNVQCIAYSPEQHA-LLSGSRDKTMTLW 259 Score = 33.9 bits (76), Expect = 0.10, Method: Compositional matrix adjust. Identities = 23/95 (24%), Positives = 38/95 (40%), Gaps = 13/95 (13%) Query: 115 IVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVA 174 + S + HD ++ + + +G S S+D +K+WD+ + V R H V V Sbjct: 534 LTSSLRRLAHDKDINALDISPNGKLFASASQDKTVKIWDVEKLEVQGILRGHKRGVWTVR 593 Query: 175 ASPHK-------------DSVFLSCSEDNRILLWD 196 +P V L+ S D I LW+ Sbjct: 594 FAPLNTPVIQGEQGSVSGRGVVLTGSGDKTIKLWN 628 Score = 28.5 bits (62), Expect = 4.3, Method: Compositional matrix adjust. Identities = 17/64 (26%), Positives = 29/64 (45%), Gaps = 8/64 (12%) Query: 141 VSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVA--ASPHKDSV------FLSCSEDNRI 192 ++GS D IK+W+L+ + ++ H+ V V DS+ F S D + Sbjct: 616 LTGSGDKTIKLWNLSDYTCIRTFEGHSHNVLKVVWLHISRDDSITKTKVQFASAGADTLV 675 Query: 193 LLWD 196 +WD Sbjct: 676 KVWD 679 >6ELZ-p nrPDB Length = 460 Score = 33.9 bits (76), Expect = 0.10, Method: Compositional matrix adjust. Identities = 21/82 (25%), Positives = 37/82 (45%), Gaps = 3/82 (3%) Query: 117 SKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAAS 176 S + ++D VS++ V +SGS D ++ WDL+ V Y H+ + V Sbjct: 95 SYLNSFSNEDWVSSLDVGDGSKHIISGSYDGIVRTWDLSGN-VQKQYSGHSGPIRAVKYI 153 Query: 177 PHKDSVFLSCSEDNRILLWDTR 198 ++ +S D + LW T+ Sbjct: 154 S--NTRLVSAGNDRTLRLWKTK 173 >3FM0-A nrPDB Length = 345 Score = 33.5 bits (75), Expect = 0.13, Method: Compositional matrix adjust. Identities = 13/39 (33%), Positives = 23/39 (58%) Query: 163 YRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPK 201 ++AH+ V CVA +P + + SCS+D + W + P+ Sbjct: 299 HQAHSQDVNCVAWNPKEPGLLASCSDDGEVAFWKYQRPE 337 Score = 30.0 bits (66), Expect = 1.4, Method: Compositional matrix adjust. Identities = 58/242 (23%), Positives = 91/242 (37%), Gaps = 55/242 (22%) Query: 80 EAGVADLTWVGERGILVA-SDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGT 138 E V + W +L S +V +WE+DE + +YE VSVL+S T Sbjct: 105 ENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEED--------EYE------CVSVLNSHT 150 Query: 139 QAV-------------SGSKDICIKVWDLAQQ--VVLSSYRAHAAQVTCVAASPHKDSVF 183 Q V S S D +K++ + V ++ H + V +A P + Sbjct: 151 QDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQRL- 209 Query: 184 LSCSEDNRILLWDTRCPKPASQIGCSA--PGY---------------------LPTSLAW 220 SCS+D + +W P + CS P + L +LA Sbjct: 210 ASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQLTGALAT 269 Query: 221 HPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSL 280 + VF ++ + T S + L A HSQ V + ++P LAS S+D + Sbjct: 270 ACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQA-HSQDVNCVAWNPKEPGLLASCSDDGEV 328 Query: 281 AV 282 A Sbjct: 329 AF 330 >5K0Y-T nrPDB Length = 329 Score = 33.5 bits (75), Expect = 0.15, Method: Compositional matrix adjust. Identities = 49/229 (21%), Positives = 79/229 (34%), Gaps = 58/229 (25%) Query: 124 HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVF 183 H+ ++ + G + +KD + VW L +Y H V CV A V Sbjct: 9 HERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTKHV- 67 Query: 184 LSCSEDNRILLWDTRCPKPA---------------------------------------- 203 L+ S DN LWD K Sbjct: 68 LTGSADNSCRLWDCETGKQLALLKTNSAVRTCGFDFGGNIIMFSTDKQMGYQCFVSFFDL 127 Query: 204 ---SQIGCSAPGYLP--------TSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSA 252 SQI + P Y+ TS W P E + G E+G ++ KS +++ Sbjct: 128 RDPSQIDNNEP-YMKIPCNDSKITSAVWGP-LGECIIAGHESGELNQYSAKSGEVLVNVK 185 Query: 253 VHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSE---LFRSQAHRD 298 HS+ + + S F+ + S+D + + DS+ E FR++ R+ Sbjct: 186 EHSRQINDIQLSREMTMFVTA-SKDNTAKLFDSTTLEHQKTFRTEPPRE 233 >3JB9-S nrPDB Length = 488 Score = 33.1 bits (74), Expect = 0.16, Method: Compositional matrix adjust. Identities = 24/77 (31%), Positives = 37/77 (48%), Gaps = 1/77 (1%) Query: 216 TSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLS 275 TSLA HP +FV G ENG + +T S + + HS V L F + + + + Sbjct: 337 TSLAVHPD-GNLFVAGLENGELRFFETSSGNELTKFGPHSSPVKTLQFGENGYWLVVTTN 395 Query: 276 EDCSLAVLDSSLSELFR 292 +D + + D SEL + Sbjct: 396 DDSDIFIWDLRKSELVQ 412 >6GMH-W nrPDB Length = 305 Score = 33.1 bits (74), Expect = 0.16, Method: Compositional matrix adjust. Identities = 33/148 (22%), Positives = 68/148 (45%), Gaps = 5/148 (3%) Query: 137 GTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWD 196 G SG+ D I ++D+A +L + HA + + SP + ++ S+D I ++D Sbjct: 160 GKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSP-DSQLLVTASDDGYIKIYD 218 Query: 197 TRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQ 256 + A + A L ++A+ P + FV + +V + D + +CV + H Sbjct: 219 VQHANLAGTLSGHASWVL--NVAFCPDDTH-FVSSSSDKSVKVWDVGTRTCVHTFFDHQD 275 Query: 257 CVTGLVFSPHSVPFLASLSEDCSLAVLD 284 V G+ ++ + + S+ +D + + D Sbjct: 276 QVWGVKYNGNGSK-IVSVGDDQEIHIYD 302 >5MWJ-A nrPDB Length = 337 Score = 33.1 bits (74), Expect = 0.17, Method: Compositional matrix adjust. Identities = 24/98 (24%), Positives = 41/98 (41%), Gaps = 2/98 (2%) Query: 101 GAVELWELDE-NETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVV 159 G V++W++ VS+ D+ + + +L G + G + + +WDLA Sbjct: 72 GCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCKLLPDGCTLIVGGEASTLSIWDLAAPTP 131 Query: 160 LSSYRAHAAQVTCVAASPHKDS-VFLSCSEDNRILLWD 196 ++ C A + DS V SC D I +WD Sbjct: 132 RIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWD 169 Score = 31.6 bits (70), Expect = 0.47, Method: Compositional matrix adjust. Identities = 29/123 (23%), Positives = 47/123 (38%), Gaps = 14/123 (11%) Query: 146 DICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQ 205 D I VWDL Q ++ ++ H +C+ S + + + DN + WD R + Q Sbjct: 162 DGNIAVWDLHNQTLVRQFQGHTDGASCIDIS-NDGTKLWTGGLDNTVRSWDLREGRQLQQ 220 Query: 206 IGCSAP----GYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGL 261 ++ GY PT E G E+ V ++ +H CV L Sbjct: 221 HDFTSQIFSLGYCPT--------GEWLAVGMESSNVEVLHVNKPD-KYQLHLHESCVLSL 271 Query: 262 VFS 264 F+ Sbjct: 272 KFA 274 Score = 30.0 bits (66), Expect = 1.6, Method: Compositional matrix adjust. Identities = 18/56 (32%), Positives = 31/56 (55%), Gaps = 4/56 (7%) Query: 101 GAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQ 156 G + +W+L N+TL V +F H D S + + + GT+ +G D ++ WDL + Sbjct: 163 GNIAVWDL-HNQTL-VRQF--QGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLRE 214 Score = 28.1 bits (61), Expect = 5.7, Method: Compositional matrix adjust. Identities = 23/103 (22%), Positives = 46/103 (44%), Gaps = 23/103 (22%) Query: 123 EHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSV 182 H ++V V++ + +G K C+KVWD++ ++ +Q+ C+ ++D+ Sbjct: 49 NHGEVVCAVTISNPTRHVYTGGKG-CVKVWDISH----PGNKSPVSQLDCL----NRDNY 99 Query: 183 FLSCS------------EDNRILLWDTRCPKP--ASQIGCSAP 211 SC E + + +WD P P +++ SAP Sbjct: 100 IRSCKLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAP 142 >3JZG-A nrPDB Length = 402 Score = 33.1 bits (74), Expect = 0.17, Method: Compositional matrix adjust. Identities = 22/92 (23%), Positives = 42/92 (45%), Gaps = 5/92 (5%) Query: 235 GTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLD---SSLSELF 291 G + +++ + C+ H + L F P L S+S+D +L + + +L +F Sbjct: 131 GIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIF 190 Query: 292 RS-QAHRDFVRDATWSPLNHSLLTTVGWDHQV 322 + HRD V A + L ++ + G DH + Sbjct: 191 GGVEGHRDEVLSADYDLLGEKIM-SCGMDHSL 221 >4PSX-B nrPDB Length = 401 Score = 33.1 bits (74), Expect = 0.19, Method: Compositional matrix adjust. Identities = 23/75 (30%), Positives = 34/75 (45%), Gaps = 8/75 (10%) Query: 135 SSGTQAVSGSKDICIKVWDLAQ-QVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRIL 193 SS A +G D + ++DL + L H V + S H D V +S DNR++ Sbjct: 263 SSNLLAAAG-MDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLM 321 Query: 194 LWDTRCPKPASQIGC 208 +WD + QIG Sbjct: 322 MWDLK------QIGA 330 >5UZ7-B nrPDB Length = 351 Score = 32.7 bits (73), Expect = 0.22, Method: Compositional matrix adjust. Identities = 21/84 (25%), Positives = 37/84 (44%), Gaps = 8/84 (9%) Query: 96 VASDSGAVELWELDENETLIVSKFCKYEHDDIV---STVSVLSSGTQAVSGSKDICIKVW 152 SD L++L ++ L+ Y HD+I+ ++VS SG ++G D VW Sbjct: 254 TGSDDATCRLFDLRADQELMT-----YSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVW 308 Query: 153 DLAQQVVLSSYRAHAAQVTCVAAS 176 D + H +V+C+ + Sbjct: 309 DALKADRAGVLAGHDNRVSCLGVT 332 Score = 29.6 bits (65), Expect = 2.1, Method: Compositional matrix adjust. Identities = 15/62 (24%), Positives = 32/62 (51%), Gaps = 1/62 (1%) Query: 141 VSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCP 200 VSG+ D K+WD+ + + ++ H + + + P+ ++ F + S+D L+D R Sbjct: 211 VSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNA-FATGSDDATCRLFDLRAD 269 Query: 201 KP 202 + Sbjct: 270 QE 271 Score = 27.7 bits (60), Expect = 6.6, Method: Compositional matrix adjust. Identities = 34/177 (19%), Positives = 65/177 (36%), Gaps = 10/177 (5%) Query: 128 VSTVSVLSSGTQAVSGSKDICIKVWDLAQQ----VVLSSYRAHAAQVTCVAASPHKDSVF 183 V T + SG G D +++L + V H ++C D+ Sbjct: 111 VMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSC--CRFLDDNQI 168 Query: 184 LSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTK 243 ++ S D LWD + + + SLA + +FV G + + L D + Sbjct: 169 VTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLA---PDTRLFVSGACDASAKLWDVR 225 Query: 244 STSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHRDFV 300 C + H + + F P+ F A+ S+D + + D + + +H + + Sbjct: 226 EGMCRQTFTGHESDINAICFFPNGNAF-ATGSDDATCRLFDLRADQELMTYSHDNII 281 >2AQ5-A nrPDB Length = 402 Score = 32.3 bits (72), Expect = 0.28, Method: Compositional matrix adjust. Identities = 24/91 (26%), Positives = 40/91 (43%), Gaps = 5/91 (5%) Query: 165 AHAAQVTCVAASPHKDSVFLSCSEDNRILLW---DTRCPKPASQIGCSAPGYLPTS--LA 219 H A V +A PH D+V S SED +++W D P + + G+ +A Sbjct: 79 GHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKRVGIVA 138 Query: 220 WHPQQSEVFVFGDENGTVSLVDTKSTSCVLS 250 WHP V + + + + D + + VL+ Sbjct: 139 WHPTAQNVLLSAGCDNVILVWDVGTGAAVLT 169 Score = 28.9 bits (63), Expect = 3.4, Method: Compositional matrix adjust. Identities = 21/78 (26%), Positives = 35/78 (44%), Gaps = 8/78 (10%) Query: 254 HSQCVTGLVFSPHSVPFLASLSEDCSLAVL---DSSLSELFRS-----QAHRDFVRDATW 305 H+ V + + PH+ +AS SEDC++ V D L R + H V W Sbjct: 80 HTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKRVGIVAW 139 Query: 306 SPLNHSLLTTVGWDHQVV 323 P ++L + G D+ ++ Sbjct: 140 HPTAQNVLLSAGCDNVIL 157 >4E5Z-B nrPDB Length = 436 Score = 32.0 bits (71), Expect = 0.37, Method: Compositional matrix adjust. Identities = 30/107 (28%), Positives = 42/107 (39%), Gaps = 10/107 (9%) Query: 160 LSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLA 219 L + R H +VT VA +P D + S D + +WD R + + S P P + A Sbjct: 243 LWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAA 302 Query: 220 WHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPH 266 F + + D KS V SA C GL+ PH Sbjct: 303 ---------CFSPDGARLLTTDQKSEIRVY-SASQWDCPLGLIPHPH 339 Score = 30.4 bits (67), Expect = 1.2, Method: Compositional matrix adjust. Identities = 20/64 (31%), Positives = 27/64 (42%), Gaps = 3/64 (4%) Query: 216 TSLAWHPQQSEVFVFGDENGTVSL--VDTKSTSCVLSSAVHSQCVTGLVFSP-HSVPFLA 272 TSLAWHP G + G + L K + +TGL F+P ++ F A Sbjct: 123 TSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYA 182 Query: 273 SLSE 276 S E Sbjct: 183 SSME 186 >3ACP-A nrPDB Length = 417 Score = 31.6 bits (70), Expect = 0.57, Method: Compositional matrix adjust. Identities = 27/105 (25%), Positives = 47/105 (44%), Gaps = 5/105 (4%) Query: 92 RGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKV 151 R ++ + G +++ LD N L + H ++ + SG +S S+D+ +K+ Sbjct: 107 RRFILGTTEGDIKV--LDSNFNL--QREIDQAHVSEITKLKFFPSGEALISSSQDMQLKI 162 Query: 152 WDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWD 196 W + + H A VT +A +V LS S D I LW+ Sbjct: 163 WSVKDGSNPRTLIGHRATVTDIAIIDRGRNV-LSASLDGTIRLWE 206 >4XFV-A nrPDB Length = 792 Score = 31.2 bits (69), Expect = 0.61, Method: Compositional matrix adjust. Identities = 17/50 (34%), Positives = 28/50 (56%), Gaps = 4/50 (8%) Query: 149 IKVWDLAQ---QVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLW 195 I +WD + + V ++ + H A+VTCV P D +S SED+ + +W Sbjct: 42 IALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSD-FMVSASEDHHVKIW 90 >5G04-R nrPDB Length = 499 Score = 31.2 bits (69), Expect = 0.64, Method: Compositional matrix adjust. Identities = 18/82 (21%), Positives = 40/82 (48%), Gaps = 4/82 (4%) Query: 94 ILVASDSGAVELWELDENETLIVSKFCKYEH-DDIVSTVSVLSSGTQAVSGSKDICIKVW 152 +L + +V LW + L + + E + +S+V+ + G G+ +++W Sbjct: 197 VLAVALDNSVYLWSASSGDIL---QLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLW 253 Query: 153 DLAQQVVLSSYRAHAAQVTCVA 174 D+ QQ L + +H+A+V ++ Sbjct: 254 DVQQQKRLRNMTSHSARVGSLS 275 Score = 28.1 bits (61), Expect = 5.2, Method: Compositional matrix adjust. Identities = 19/65 (29%), Positives = 36/65 (55%), Gaps = 6/65 (9%) Query: 132 SVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPH-KDSVFLSCSEDN 190 +VL++G G+ D I++W++ LS+ AH +QV + SPH K+ + N Sbjct: 369 NVLATG----GGTSDRHIRIWNVCSGACLSAVDAH-SQVCSILWSPHYKELISGHGFAQN 423 Query: 191 RILLW 195 ++++W Sbjct: 424 QLVIW 428 >6BX3-A nrPDB Length = 314 Score = 30.8 bits (68), Expect = 0.82, Method: Compositional matrix adjust. Identities = 27/103 (26%), Positives = 44/103 (42%), Gaps = 5/103 (4%) Query: 94 ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWD 153 I ASD +VE+ L ++ F H V +++ G + S D IK+WD Sbjct: 69 IATASDDFSVEIIHLSYG---LLHTFIG--HTAPVISLTFNRKGNLLFTSSMDESIKIWD 123 Query: 154 LAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWD 196 ++ + AH+ V V + S+ S S D I ++D Sbjct: 124 TLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFD 166 >4GGA-A nrPDB Length = 420 Score = 30.8 bits (68), Expect = 1.0, Method: Compositional matrix adjust. Identities = 18/82 (21%), Positives = 40/82 (48%), Gaps = 4/82 (4%) Query: 94 ILVASDSGAVELWELDENETLIVSKFCKYEH-DDIVSTVSVLSSGTQAVSGSKDICIKVW 152 +L + +V LW + L + + E + +S+V+ + G G+ +++W Sbjct: 118 VLAVALDNSVYLWSASSGDIL---QLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLW 174 Query: 153 DLAQQVVLSSYRAHAAQVTCVA 174 D+ QQ L + +H+A+V ++ Sbjct: 175 DVQQQKRLRNMTSHSARVGSLS 196 Score = 28.1 bits (61), Expect = 6.2, Method: Compositional matrix adjust. Identities = 19/65 (29%), Positives = 36/65 (55%), Gaps = 6/65 (9%) Query: 132 SVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPH-KDSVFLSCSEDN 190 +VL++G G+ D I++W++ LS+ AH +QV + SPH K+ + N Sbjct: 290 NVLATG----GGTSDRHIRIWNVCSGACLSAVDAH-SQVCSILWSPHYKELISGHGFAQN 344 Query: 191 RILLW 195 ++++W Sbjct: 345 QLVIW 349 >5LCW-Q nrPDB Length = 374 Score = 30.4 bits (67), Expect = 1.1, Method: Compositional matrix adjust. Identities = 18/78 (23%), Positives = 38/78 (48%), Gaps = 4/78 (5%) Query: 94 ILVASDSGAVELWELDENETLIVSKFCKYEH-DDIVSTVSVLSSGTQAVSGSKDICIKVW 152 +L + +V LW + L + + E + +S+V+ + G G+ +++W Sbjct: 72 VLAVALDNSVYLWSASSGDIL---QLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLW 128 Query: 153 DLAQQVVLSSYRAHAAQV 170 D+ QQ L + +H+A+V Sbjct: 129 DVQQQKRLRNMTSHSARV 146 Score = 27.7 bits (60), Expect = 6.6, Method: Compositional matrix adjust. Identities = 19/65 (29%), Positives = 36/65 (55%), Gaps = 6/65 (9%) Query: 132 SVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPH-KDSVFLSCSEDN 190 +VL++G G+ D I++W++ LS+ AH +QV + SPH K+ + N Sbjct: 244 NVLATG----GGTSDRHIRIWNVCSGACLSAVDAH-SQVCSILWSPHYKELISGHGFAQN 298 Query: 191 RILLW 195 ++++W Sbjct: 299 QLVIW 303 >5K1H-B nrPDB Length = 576 Score = 30.4 bits (67), Expect = 1.1, Method: Compositional matrix adjust. Identities = 30/107 (28%), Positives = 44/107 (41%), Gaps = 6/107 (5%) Query: 217 SLAWHPQQSEVFVFGDE--NGTVSLVDTKSTSCV-LSSAVHSQCVTGLVFSPH-SVPFLA 272 + AW P S+ V E +VS KS + LS Q + +SP LA Sbjct: 398 AFAWEPNGSKFAVLHGEAPRISVSFYHVKSNGKIELSKMFDKQQANTIFWSPQGQFVVLA 457 Query: 273 SL-SEDCSLAVLDSSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGW 318 L S + +LA +D+S + H D W P ++T+V W Sbjct: 458 GLRSMNGALAFVDTSDCTVMNIAEHY-MASDVEWDPTGRYVVTSVSW 503 >4N14-A nrPDB Length = 314 Score = 30.4 bits (67), Expect = 1.2, Method: Compositional matrix adjust. Identities = 18/78 (23%), Positives = 38/78 (48%), Gaps = 4/78 (5%) Query: 94 ILVASDSGAVELWELDENETLIVSKFCKYEH-DDIVSTVSVLSSGTQAVSGSKDICIKVW 152 +L + +V LW + L + + E + +S+V+ + G G+ +++W Sbjct: 34 VLAVALDNSVYLWSASSGDIL---QLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLW 90 Query: 153 DLAQQVVLSSYRAHAAQV 170 D+ QQ L + +H+A+V Sbjct: 91 DVQQQKRLRNMTSHSARV 108 Score = 28.1 bits (61), Expect = 6.1, Method: Compositional matrix adjust. Identities = 19/65 (29%), Positives = 36/65 (55%), Gaps = 6/65 (9%) Query: 132 SVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPH-KDSVFLSCSEDN 190 +VL++G G+ D I++W++ LS+ AH +QV + SPH K+ + N Sbjct: 206 NVLATG----GGTSDRHIRIWNVCSGACLSAVDAH-SQVCSILWSPHYKELISGHGFAQN 260 Query: 191 RILLW 195 ++++W Sbjct: 261 QLVIW 265 >3ODT-A nrPDB Length = 313 Score = 30.0 bits (66), Expect = 1.6, Method: Compositional matrix adjust. Identities = 31/128 (24%), Positives = 51/128 (39%), Gaps = 9/128 (7%) Query: 140 AVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLW-DTR 198 +SGS D KVW + ++ + +AH A V ++ FL+ S D I LW + + Sbjct: 117 VISGSWDKTAKVW--KEGSLVYNLQAHNASVWDAKVVSFSENKFLTASADKTIKLWQNDK 174 Query: 199 CPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCV 258 K S I +L H F+ +G + LVD + + + H V Sbjct: 175 VIKTFSGIHNDVVRHLAVVDDGH------FISCSNDGLIKLVDMHTGDVLRTYEGHESFV 228 Query: 259 TGLVFSPH 266 + P+ Sbjct: 229 YCIKLLPN 236 >3EI3-B nrPDB Length = 383 Score = 30.0 bits (66), Expect = 1.7, Method: Compositional matrix adjust. Identities = 18/80 (22%), Positives = 35/80 (43%), Gaps = 4/80 (5%) Query: 216 TSLAWHPQQSEVFVFGDENGTVSL--VDTKSTSCVLSSAVHSQCVTGLVFSPHSVP--FL 271 TSL WHP G + G + L D ++ + + +TG+ F+ + F+ Sbjct: 77 TSLEWHPTHPTTVAVGSKGGDIILWDYDVQNKTSFIQGMGPGDAITGMKFNQFNTNQLFV 136 Query: 272 ASLSEDCSLAVLDSSLSELF 291 +S+ +L S+ ++F Sbjct: 137 SSIRGATTLRDFSGSVIQVF 156 Score = 28.9 bits (63), Expect = 3.0, Method: Compositional matrix adjust. Identities = 19/77 (24%), Positives = 33/77 (42%), Gaps = 1/77 (1%) Query: 164 RAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAW-HP 222 + H A+VT +P D + + S D + LWD R K + P P + A+ +P Sbjct: 201 KLHKAKVTHAEFNPRCDWLMATSSVDATVKLWDLRNIKDKNSYIAEMPHEKPVNAAYFNP 260 Query: 223 QQSEVFVFGDENGTVSL 239 S + D+ + + Sbjct: 261 TDSTKLLTTDQRNEIRV 277 >3DW8-B nrPDB Length = 447 Score = 30.0 bits (66), Expect = 1.7, Method: Compositional matrix adjust. Identities = 32/184 (17%), Positives = 80/184 (43%), Gaps = 27/184 (14%) Query: 77 VQTEAGVADLTWVGERG---ILVASDSGAVELWELDENETL-----IVSKFCKYEHDDIV 128 ++ E + + W+ ++ L++++ ++LW++ E + + + +Y V Sbjct: 90 LEIEEKINKIRWLPQKNAAQFLLSTNDKTIKLWKISERDKRPEGYNLKEEDGRYRDPTTV 149 Query: 129 STVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSE 188 +T+ V V D+ ++ + + + ++ AH + ++ + ++ +LS ++ Sbjct: 150 TTLRV------PVFRPMDLMVEA---SPRRIFAN--AHTYHINSISINSDYET-YLS-AD 196 Query: 189 DNRILLWDTRCPKPASQIGCSAPGYLP------TSLAWHPQQSEVFVFGDENGTVSLVDT 242 D RI LW + I P + T+ +HP FV+ GT+ L D Sbjct: 197 DLRINLWHLEITDRSFNIVDIKPANMEELTEVITAAEFHPNSCNTFVYSSSKGTIRLCDM 256 Query: 243 KSTS 246 ++++ Sbjct: 257 RASA 260 >5OQL-X nrPDB Length = 630 Score = 29.3 bits (64), Expect = 2.9, Method: Compositional matrix adjust. Identities = 32/138 (23%), Positives = 54/138 (39%), Gaps = 24/138 (17%) Query: 123 EHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSV 182 +H D V+ ++ Q S SKD +KVW L + + + H ++ + A + V Sbjct: 286 QHRDAVTGLAFRRGTNQLYSCSKDRTVKVWSLDELAYVETLFGHQDEILDIDALGQERCV 345 Query: 183 FLSCSEDNRILLWDTRCPKPASQI------GCSA--------PGYLPTSLAWHPQQSEV- 227 + + D W + P+ + + G S+ PG P S A V Sbjct: 346 SVG-ARDRTARYW--KVPEESQLVFRGGGEGGSSNTKKHKLPPGMDPASAAHEGSMDRVA 402 Query: 228 ------FVFGDENGTVSL 239 FV G +NG ++L Sbjct: 403 MIDDDMFVTGSDNGDLAL 420 >5BJS-A nrPDB Length = 605 Score = 29.3 bits (64), Expect = 2.9, Method: Compositional matrix adjust. Identities = 20/91 (21%), Positives = 38/91 (41%), Gaps = 6/91 (6%) Query: 149 IKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQ--- 205 +KV+++ + + + H + +A SP + S S+D I +W + P+ Q Sbjct: 160 VKVYNVTEGKLYRTLVGHGGGINDLATSPANPYIIASASDDTTIRIW-SLAPEHEKQPCV 218 Query: 206 --IGCSAPGYLPTSLAWHPQQSEVFVFGDEN 234 +G Y S+A+H V G + Sbjct: 219 CILGGEGHSYDLLSVAFHDNGRYVLSAGHDQ 249 >5WYJ-BC nrPDB Length = 817 Score = 28.9 bits (63), Expect = 3.0, Method: Compositional matrix adjust. Identities = 19/60 (31%), Positives = 28/60 (46%), Gaps = 5/60 (8%) Query: 142 SGSKDICIKVWDLAQQVVLSSYRAHAAQVTC--VAASPHKDS---VFLSCSEDNRILLWD 196 SG + +KVWDL ++ L + + H + V + P D LS D+ I LWD Sbjct: 165 SGDTNGMVKVWDLVKRKCLHTLQEHTSAVRGLDIIEVPDNDEPSLNLLSGGRDDIINLWD 224 Score = 28.5 bits (62), Expect = 4.7, Method: Compositional matrix adjust. Identities = 27/103 (26%), Positives = 45/103 (43%), Gaps = 7/103 (6%) Query: 95 LVASDSG--AVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVW 152 L+A+ SG V++W LD T V K + H + V S ++ Q +S D IK+W Sbjct: 547 LLATSSGDKTVKIWSLD---TFSVMKTLE-GHTNAVQRCSFINKQKQLISCGADGLIKIW 602 Query: 153 DLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLW 195 D + L + H ++ ++ D + +S D W Sbjct: 603 DCSSGECLKTLDGHNNRLWALSTMNDGDMI-VSADADGVFQFW 644 Score = 28.1 bits (61), Expect = 5.2, Method: Compositional matrix adjust. Identities = 23/79 (29%), Positives = 34/79 (43%), Gaps = 17/79 (21%) Query: 119 FCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVT-CVAASP 177 FC+Y D +++T SSG D +K+W L V+ + H V C + Sbjct: 541 FCQY--DKLLAT----SSG--------DKTVKIWSLDTFSVMKTLEGHTNAVQRCSFINK 586 Query: 178 HKDSVFLSCSEDNRILLWD 196 K +SC D I +WD Sbjct: 587 QKQ--LISCGADGLIKIWD 603 Score = 28.1 bits (61), Expect = 6.1, Method: Compositional matrix adjust. Identities = 25/94 (26%), Positives = 39/94 (41%), Gaps = 11/94 (11%) Query: 122 YE-HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQV----VLSSYRAHAAQVTCVA-- 174 YE H+D+++++ G + SKD VW + + + Y H+A VT V Sbjct: 384 YEGHEDLLNSLDATEDGLWIATASKDNTAIVWRYNENSCKFDIYAKYIGHSAAVTAVGLP 443 Query: 175 --ASPHKDSVFLSCSEDNRILLWDTRCPKPASQI 206 S L+ S D I W PKP + + Sbjct: 444 NIVSKGYPEFLLTASNDLTIKKW--IIPKPTASM 475 >2JIP-A nrPDB Length = 723 Score = 28.9 bits (63), Expect = 3.2, Method: Compositional matrix adjust. Identities = 34/136 (25%), Positives = 50/136 (36%), Gaps = 31/136 (22%) Query: 161 SSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLA- 219 +S R Q CV A H D F D R ++W A + P YL TS+ Sbjct: 561 TSLRYVRGQDPCVPAD-HPDRFFFYGKPDGRAVIWMRPAKGAAEEPDAEYPLYL-TSMRV 618 Query: 220 ---WHP----------QQSEVFVF-----------GDENGTVSLVDTKSTSCVLSSAVHS 255 WH Q++ F G ++G +V+T+ + L + V Sbjct: 619 IDHWHTATMTGKVPELQKANPIAFVEINEEDAARTGIKHGDSVIVETRRDAMELPARVSD 678 Query: 256 QCVTGLVFSPHSVPFL 271 C GL+ +VPF Sbjct: 679 VCRPGLI----AVPFF 690 >5GAN-H nrPDB Length = 465 Score = 28.9 bits (63), Expect = 3.7, Method: Compositional matrix adjust. Identities = 24/95 (25%), Positives = 42/95 (44%), Gaps = 5/95 (5%) Query: 104 ELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSY 163 LW+ ++ L++ + HD V ++S G+ SG D +WD+ + + Sbjct: 290 RLWDASTHQELLLQE----GHDKGVFSLSFQCDGSLVCSGGMDSLSMLWDIRSGSKVMTL 345 Query: 164 RAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTR 198 H+ + VA SP+ V + D I +WD R Sbjct: 346 AGHSKPIYTVAWSPNGYQV-ATGGGDGIINVWDIR 379 >1NR0-A nrPDB Length = 611 Score = 28.9 bits (63), Expect = 3.7, Method: Compositional matrix adjust. Identities = 16/41 (39%), Positives = 26/41 (63%), Gaps = 3/41 (7%) Query: 161 SSYRAHAAQVTCVAASPHKDSVFLSC-SEDNRILLWDTRCP 200 +S+ H A+V CV+ SP D+V L+ S DN +++W+ P Sbjct: 530 NSWTFHTAKVACVSWSP--DNVRLATGSLDNSVIVWNMNKP 568 >5K19-A nrPDB Length = 569 Score = 28.5 bits (62), Expect = 4.9, Method: Compositional matrix adjust. Identities = 14/46 (30%), Positives = 22/46 (47%) Query: 137 GTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSV 182 G V+G +D + VW V++ H + V+ VA P+ SV Sbjct: 274 GKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSV 319 Score = 27.3 bits (59), Expect = 9.6, Method: Compositional matrix adjust. Identities = 34/124 (27%), Positives = 49/124 (39%), Gaps = 20/124 (16%) Query: 168 AQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEV 227 ++VTCV P +S+FL + L++ G +AP Y +Q E Sbjct: 150 SRVTCVKWVPGSESLFLVAHSSGNMYLYNVE-----HTCGTTAPHYQLL------KQGES 198 Query: 228 FVFGDENGTVSLVDTKSTSC-VLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSS 286 F V +KST +L V + FSP FLA +S+D L V + Sbjct: 199 FA-------VHTCKSKSTRNPLLKWTVGEGALNEFAFSPDG-KFLACVSQDGFLRVFNFD 250 Query: 287 LSEL 290 EL Sbjct: 251 SVEL 254 >6B1B-A nrPDB Length = 527 Score = 28.1 bits (61), Expect = 5.7, Method: Compositional matrix adjust. Identities = 16/58 (27%), Positives = 26/58 (44%) Query: 249 LSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHRDFVRDATWS 306 L S + V G SP+ P + E+ ++ V+D+ L +RDF R W+ Sbjct: 242 LISRASYEMVAGATGSPYDYPLSSRFDENDAILVMDNVLIPWENVLIYRDFDRCRRWT 299 >6GB2-BC nrPDB Length = 657 Score = 28.1 bits (61), Expect = 5.9, Method: Compositional matrix adjust. Identities = 23/75 (30%), Positives = 34/75 (45%), Gaps = 3/75 (4%) Query: 40 GALLLGASSLSGRCWAGSLWLFKDPCAAPNEGFCSAGVQTEAGVADLTWVGERGILVASD 99 G L G+ ++G+CWA +F + +E + S V G DL GE + V S+ Sbjct: 309 GTLRKGSVLVAGKCWAKVRLMFDENGKTIDEAYPSMPVGI-TGWRDLPSAGEEILEVESE 367 Query: 100 SGAVEL--WELDENE 112 A E+ W E E Sbjct: 368 PRAREVVDWRKYEQE 382 >4YCZ-A nrPDB Length = 876 Score = 27.7 bits (60), Expect = 7.3, Method: Compositional matrix adjust. Identities = 65/256 (25%), Positives = 102/256 (39%), Gaps = 35/256 (13%) Query: 86 LTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVL--SSGTQAVSG 143 L + G R +SD ++++E+ E ET +++ K HD V VS G S Sbjct: 26 LDYYGRRLATCSSDR-TIKIFEI-EGETQRLTETLK-GHDGAVWCVSWAHPKYGNILASA 82 Query: 144 SKDICIKVW---DLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSC-SEDNRILLWDTRC 199 D + +W + A Q + + H A V V+ SPH+ L+C S D + + + R Sbjct: 83 GYDGKVLIWRELNGAWQRIFD-FALHKASVNVVSWSPHEAGCLLACASSDGNVSVLEFRD 141 Query: 200 PKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVT 259 I A G S++W P S + + G KST + + VT Sbjct: 142 NSWEHSI-FHAHGLGVNSVSWAPATSPGSIVSSKPG------PKSTG-------NRRFVT 187 Query: 260 GLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHRDFVRDATWSP--LNHSLLTTVG 317 G S +++ A + + L+ H D+VRD WSP L S + + Sbjct: 188 G--GSDNALKIWAYDPATNTYKLEREPLT------GHTDWVRDVAWSPTVLQKSYIASAS 239 Query: 318 WDHQV-VHHVVPTEPL 332 D V + P PL Sbjct: 240 EDRTVRIWTSDPANPL 255 >1A8S-A nrPDB Length = 273 Score = 27.7 bits (60), Expect = 7.4, Method: Compositional matrix adjust. Identities = 11/30 (36%), Positives = 17/30 (56%) Query: 60 LFKDPCAAPNEGFCSAGVQTEAGVADLTWV 89 L+KD + P GF G ++ AG+ D W+ Sbjct: 154 LYKDLASGPFFGFNQPGAKSSAGMVDWFWL 183 >4H0P-A nrPDB Length = 438 Score = 27.7 bits (60), Expect = 7.6, Method: Compositional matrix adjust. Identities = 31/138 (22%), Positives = 60/138 (43%), Gaps = 16/138 (11%) Query: 136 SGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRIL-- 193 G + V G ++ +++ L++ L ++RA A +C+ A PH S+ L + +R + Sbjct: 109 KGIRVVKGHEEGLMEMDKLSEFAPLHNHRAVLAVKSCIDALPHHTSLLLFDTIFHRTIAP 168 Query: 194 -LW-------DTRCPKPASQIGCSAPGY--LPTSLAWHPQQSEVFVFGDENGTVSLVDTK 243 ++ DT P + G Y + SLA H ++ + N V+ + + Sbjct: 169 EVYTYALPPPDTELTMPLRKYGFHGLSYASIVQSLAEHLKKPSDQI----NVVVAHLGSG 224 Query: 244 STSCVLSSAVHSQCVTGL 261 S+SC + + GL Sbjct: 225 SSSCCIKNGKSIDTSMGL 242 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 5FA5-B nrPDB 485 e-137 4G56-B nrPDB 364 e-101 5M25-A nrPDB 207 5e-54 5MZH-A nrPDB 204 4e-53 2H9P-A nrPDB 203 1e-52 1VYH-C nrPDB 201 5e-52 6EOJ-D nrPDB 198 2e-51 5NZU-C nrPDB 196 2e-50 6F3T-A nrPDB 194 5e-50 5NNZ-B nrPDB 194 6e-50 6HQA-B nrPDB 193 1e-49 6MZM-G nrPDB 191 3e-49 3MKQ-A nrPDB 190 7e-49 6QX9-4B nrPDB 187 5e-48 2YNP-A nrPDB 186 1e-47 3DM0-A nrPDB 175 2e-44 4V6W-Ag nrPDB 173 1e-43 4L9O-A nrPDB 171 4e-43 6G51-g nrPDB 171 5e-43 6QDV-o nrPDB 171 6e-43 5FVM-C nrPDB 170 7e-43 3C9C-A nrPDB 170 9e-43 3CFV-B nrPDB 169 1e-42 5YZG-W nrPDB 169 1e-42 5Y1U-A nrPDB 169 2e-42 6QX9-5O nrPDB 166 9e-42 6EMK-B nrPDB 166 1e-41 6N9G-C nrPDB 166 2e-41 5OPT-p nrPDB 162 2e-40 3BG0-A nrPDB 162 2e-40 4BTS-AR nrPDB 161 3e-40 3JRP-A nrPDB 161 4e-40 4V8M-A7 nrPDB 161 4e-40 4BZK-B nrPDB 156 1e-38 5XYI-g nrPDB 156 2e-38 5L9T-R nrPDB 155 2e-38 4LG8-A nrPDB 154 4e-38 5FL8-q nrPDB 154 5e-38 5Z56-q nrPDB 154 6e-38 6ID0-T nrPDB 153 9e-38 5A31-R nrPDB 152 2e-37 4BH6-A nrPDB 149 1e-36 4XYI-A nrPDB 148 4e-36 3JB9-L nrPDB 144 5e-35 5WJC-A nrPDB 144 6e-35 5WLC-LU nrPDB 143 1e-34 5WLC-LO nrPDB 142 2e-34 5I2T-A nrPDB 142 2e-34 5WYJ-BE nrPDB 142 3e-34 6J6H-n nrPDB 141 5e-34 3JAP-g nrPDB 141 6e-34 3JB9-g nrPDB 141 6e-34 5K1B-B nrPDB 128 3e-30 5WYK-BB nrPDB 118 3e-27 5WLC-LN nrPDB 115 3e-26 6E29-D nrPDB 112 3e-25 Sequences not found previously or not previously below threshold: 3JRO-A nrPDB 171 3e-43 4YCZ-A nrPDB 163 1e-40 5Y88-O nrPDB 145 3e-35 6HHQ-h nrPDB 144 6e-35 4V7E-Bg nrPDB 141 3e-34 5GAN-H nrPDB 135 3e-32 5UZ7-B nrPDB 134 5e-32 5WYJ-BC nrPDB 131 3e-31 6Q8F-A nrPDB 127 7e-30 4AEZ-A nrPDB 127 7e-30 3FM0-A nrPDB 124 8e-29 5OQL-d nrPDB 122 2e-28 6GMH-W nrPDB 119 2e-27 2HES-X nrPDB 118 3e-27 4GGA-A nrPDB 118 4e-27 4A11-B nrPDB 118 4e-27 5G04-R nrPDB 117 5e-27 3W15-A nrPDB 117 5e-27 5LCW-Q nrPDB 117 6e-27 5WBU-D nrPDB 117 1e-26 5OQL-J nrPDB 115 2e-26 6BX3-A nrPDB 115 3e-26 4N14-A nrPDB 115 3e-26 6CHG-A nrPDB 110 7e-25 6ELZ-p nrPDB 109 2e-24 4J0W-A nrPDB 106 1e-23 4PSX-B nrPDB 106 1e-23 3ODT-A nrPDB 105 2e-23 5CXC-A nrPDB 103 1e-22 5A9Q-2 nrPDB 102 2e-22 2AQ5-A nrPDB 102 2e-22 5MWJ-A nrPDB 100 1e-21 5A9Q-7 nrPDB 99 3e-21 5OQL-L nrPDB 99 3e-21 1NR0-A nrPDB 98 4e-21 4XFV-A nrPDB 98 4e-21 5N4A-A nrPDB 98 6e-21 4U1E-I nrPDB 96 2e-20 5K0Y-T nrPDB 92 4e-19 2PM9-A nrPDB 91 5e-19 5WLC-LJ nrPDB 91 7e-19 3F3P-A nrPDB 91 7e-19 3ACP-A nrPDB 88 4e-18 6F1U-h nrPDB 87 1e-17 5OQL-X nrPDB 86 3e-17 1PI6-A nrPDB 84 7e-17 5A9Q-0 nrPDB 84 1e-16 5BJS-A nrPDB 83 2e-16 6BX3-B nrPDB 83 2e-16 4OWR-A nrPDB 82 3e-16 2P9P-C nrPDB 82 4e-16 6C0F-s nrPDB 79 2e-15 6EM1-m nrPDB 78 4e-15 6CB1-s nrPDB 78 5e-15 3JZG-A nrPDB 75 5e-14 5YZG-2 nrPDB 74 8e-14 3JB9-S nrPDB 73 2e-13 4E5Z-B nrPDB 71 7e-13 5TF2-A nrPDB 71 8e-13 5OV3-A nrPDB 69 2e-12 3EI3-B nrPDB 68 5e-12 5K19-A nrPDB 68 6e-12 3I2N-A nrPDB 68 7e-12 5CXB-B nrPDB 67 7e-12 5M89-A nrPDB 65 4e-11 5WLC-SG nrPDB 65 4e-11 4J0X-A nrPDB 65 4e-11 5AJA-A nrPDB 59 2e-09 5WLC-LW nrPDB 59 3e-09 6CHG-D nrPDB 58 7e-09 3DW8-B nrPDB 57 8e-09 6CVZ-A nrPDB 57 8e-09 5MC6-j nrPDB 54 6e-08 3DWL-C nrPDB 53 1e-07 5LTD-A nrPDB 52 4e-07 5AMS-A nrPDB 51 6e-07 4AV8-A nrPDB 49 2e-06 6IYY-A nrPDB 49 3e-06 5WLC-LH nrPDB 48 5e-06 4FHN-A nrPDB 47 8e-06 5WLC-LV nrPDB 47 1e-05 2VDU-B nrPDB 46 2e-05 2I3T-A nrPDB 46 3e-05 6NAU-A nrPDB 42 5e-04 5WLC-LL nrPDB 42 5e-04 6N8P-A nrPDB 41 7e-04 4YHC-A nrPDB 40 0.001 5K1H-B nrPDB 39 0.004 5GRS-A nrPDB 39 0.005 5WLC-LS nrPDB 38 0.006 1RI6-A nrPDB 34 0.13 2FRX-A nrPDB 32 0.26 6GC1-A nrPDB 32 0.28 4R40-A nrPDB 32 0.41 3UBH-A nrPDB 30 1.3 5IV7-F nrPDB 30 1.6 4NOX-A nrPDB 30 1.6 5W0U-B nrPDB 30 1.7 1OGY-B nrPDB 30 1.8 1KHE-A nrPDB 30 1.9 4GMM-A nrPDB 29 2.9 1Z68-A nrPDB 29 3.8 4TLF-A nrPDB 27 8.4 >5FA5-B nrPDB Length = 367 Score = 485 bits (1247), Expect = e-137, Method: Composition-based stats. Identities = 341/342 (99%), Positives = 342/342 (100%) Query: 1 MRKETPPPLVPPAAREWNLPPNAPACMERQLEAARYRSDGALLLGASSLSGRCWAGSLWL 60 +RKETPPPLVPPAAREWNLPPNAPACMERQLEAARYRSDGALLLGASSLSGRCWAGSLWL Sbjct: 26 LRKETPPPLVPPAAREWNLPPNAPACMERQLEAARYRSDGALLLGASSLSGRCWAGSLWL 85 Query: 61 FKDPCAAPNEGFCSAGVQTEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFC 120 FKDPCAAPNEGFCSAGVQTEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFC Sbjct: 86 FKDPCAAPNEGFCSAGVQTEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFC 145 Query: 121 KYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKD 180 KYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKD Sbjct: 146 KYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKD 205 Query: 181 SVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLV 240 SVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLV Sbjct: 206 SVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLV 265 Query: 241 DTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHRDFV 300 DTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHRDFV Sbjct: 266 DTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHRDFV 325 Query: 301 RDATWSPLNHSLLTTVGWDHQVVHHVVPTEPLPAPGPASVTE 342 RDATWSPLNHSLLTTVGWDHQVVHHVVPTEPLPAPGPASVTE Sbjct: 326 RDATWSPLNHSLLTTVGWDHQVVHHVVPTEPLPAPGPASVTE 367 >4G56-B nrPDB Length = 357 Score = 364 bits (934), Expect = e-101, Method: Composition-based stats. Identities = 201/314 (64%), Positives = 243/314 (77%) Query: 17 WNLPPNAPACMERQLEAARYRSDGALLLGASSLSGRCWAGSLWLFKDPCAAPNEGFCSAG 76 W P APACME Q+ A RYR DGALLL ASSLS R W GS+W+FKDP APNE C+AG Sbjct: 31 WGRPVTAPACMEVQIGAVRYRRDGALLLAASSLSSRTWGGSIWVFKDPEGAPNESLCTAG 90 Query: 77 VQTEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSS 136 VQTEAGV D+ WV E+GILVASDSGAVELWE+ E E+L+V+KF KYEHDDIV T+SV S Sbjct: 91 VQTEAGVTDVAWVSEKGILVASDSGAVELWEILEKESLLVNKFAKYEHDDIVKTLSVFSD 150 Query: 137 GTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWD 196 GTQAVSG KD +KVWDL+Q+ VL SY AH+++V CVAA P KD++FLSC ED RILLWD Sbjct: 151 GTQAVSGGKDFSVKVWDLSQKAVLKSYNAHSSEVNCVAACPGKDTIFLSCGEDGRILLWD 210 Query: 197 TRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQ 256 TR PKPA++I A +PTS+ WHP++ + F GDE G VSLV+ K+ +SAVHSQ Sbjct: 211 TRKPKPATRIDFCASDTIPTSVTWHPEKDDTFACGDETGNVSLVNIKNPDSAQTSAVHSQ 270 Query: 257 CVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHRDFVRDATWSPLNHSLLTTV 316 +TGL +S HS PFLAS+SEDC++AVLD+ SE+FR +HRDFV WSPL+HS TTV Sbjct: 271 NITGLAYSYHSSPFLASISEDCTVAVLDADFSEVFRDLSHRDFVTGVAWSPLDHSKFTTV 330 Query: 317 GWDHQVVHHVVPTE 330 GWDH+V+HH +P+E Sbjct: 331 GWDHKVLHHHLPSE 344 >5M25-A nrPDB Length = 434 Score = 207 bits (527), Expect = 5e-54, Method: Composition-based stats. Identities = 65/313 (20%), Positives = 121/313 (38%), Gaps = 28/313 (8%) Query: 3 KETPPPLVPPAAREWNLPPNAPACMERQLEAARYRSDGALLLGASSLSGRCWAGSLWLFK 62 + P P+ P A ++ L + A + + ++ +G L ASS + + +W Sbjct: 125 QSKPTPVKPNYALKFTLAGHTKA-----VSSVKFSPNGEWL--ASSSADKLI--KIWGAY 175 Query: 63 DPCAAPNEGFCSAGVQ-TEAGVADLTWVGERGILV-ASDSGAVELWELDENETLIVSKFC 120 D G + + G++D+ W + +LV ASD +++W++ + L K Sbjct: 176 D-------GKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLK-- 226 Query: 121 KYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKD 180 H + V + VSGS D +++WD+ L + AH+ V+ V + Sbjct: 227 --GHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN-RDG 283 Query: 181 SVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLV 240 S+ +S S D +WDT + + P S + + + T+ L Sbjct: 284 SLIVSSSYDGLCRIWDTASGQCLKTLIDD--DNPPVSFVKFSPNGKYILAATLDNTLKLW 341 Query: 241 DTKSTSCVLSSAVHSQCVTGL--VFSPHSVPFLASLSEDCSLAVLDSSLSEL-FRSQAHR 297 D C+ + H + FS ++ S SED + + + E+ + Q H Sbjct: 342 DYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHT 401 Query: 298 DFVRDATWSPLNH 310 D V P + Sbjct: 402 DVVISTACHPTEN 414 Score = 166 bits (420), Expect = 1e-41, Method: Composition-based stats. Identities = 48/255 (18%), Positives = 105/255 (41%), Gaps = 14/255 (5%) Query: 83 VADLTWVGE-RGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAV 141 V+ + + + +S +++W + + + H +S V+ S V Sbjct: 148 VSSVKFSPNGEWLASSSADKLIKIWGAYDGK----FEKTISGHKLGISDVAWSSDSNLLV 203 Query: 142 SGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPK 201 S S D +K+WD++ L + + H+ V C +P + ++ +S S D + +WD + K Sbjct: 204 SASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNP-QSNLIVSGSFDESVRIWDVKTGK 262 Query: 202 PASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQ-CVTG 260 + A +++ ++ + + V +G + DT S C+ + V+ Sbjct: 263 CLKTL--PAHSDPVSAVHFN-RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSF 319 Query: 261 LVFSPHSVPFLASLSEDCSLAVLDSSLSELFRS-QAH--RDFVRDATWSPLNHSLLTTVG 317 + FSP+ LA+ D +L + D S + ++ H + A +S + + Sbjct: 320 VKFSPNGKYILAAT-LDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGS 378 Query: 318 WDHQVVHHVVPTEPL 332 D+ V + T+ + Sbjct: 379 EDNLVYIWNLQTKEI 393 Score = 161 bits (406), Expect = 5e-40, Method: Composition-based stats. Identities = 45/214 (21%), Positives = 83/214 (38%), Gaps = 8/214 (3%) Query: 112 ETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVT 171 + KF H VS+V +G S S D IK+W + H ++ Sbjct: 132 KPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGIS 191 Query: 172 CVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFG 231 VA S + + +S S+D + +WD K + ++PQ + + V G Sbjct: 192 DVAWSSDSN-LLVSASDDKTLKIWDVSSGKCLKTLK--GHSNYVFCCNFNPQSN-LIVSG 247 Query: 232 DENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELF 291 + +V + D K+ C+ + HS V+ + F+ + S S D + D++ + Sbjct: 248 SFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDG-SLIVSSSYDGLCRIWDTASGQCL 306 Query: 292 RSQAHRDF--VRDATWSPLNHSLLTTVGWDHQVV 323 ++ D V +SP N + D+ + Sbjct: 307 KTLIDDDNPPVSFVKFSP-NGKYILAATLDNTLK 339 Score = 83.3 bits (204), Expect = 2e-16, Method: Composition-based stats. Identities = 37/177 (20%), Positives = 73/177 (41%), Gaps = 24/177 (13%) Query: 31 LEAARYRSDGALLLGASSLSGRCWAGSLWLFKDPCAAPNEGFCSAGVQTEAG--VADLTW 88 + A + DG+L++ +SS G C +W G C + + V+ + + Sbjct: 274 VSAVHFNRDGSLIV-SSSYDGLC---RIWDTA-------SGQCLKTLIDDDNPPVSFVKF 322 Query: 89 VGE-RGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTV--SVLSSG-TQAVSGS 144 + IL A+ ++LW+ + + L H + + + +G VSGS Sbjct: 323 SPNGKYILAATLDNTLKLWDYSKGKCLKTY----TGHKNEKYCIFANFSVTGGKWIVSGS 378 Query: 145 KDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSE--DNRILLWDTRC 199 +D + +W+L + ++ + H V A P ++ + S + D I LW + C Sbjct: 379 EDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTEN-IIASAALENDKTIKLWKSDC 434 >5MZH-A nrPDB Length = 452 Score = 204 bits (519), Expect = 4e-53, Method: Composition-based stats. Identities = 45/243 (18%), Positives = 92/243 (37%), Gaps = 12/243 (4%) Query: 89 VGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSV-LSSGTQAVSGSKDI 147 + S ++W E + + H ++V ++ G + V+GS D Sbjct: 104 KSGDRFITGSYDRTCKVWNTFTGEEVFTLE----GHKNVVYAIAFNNPYGDKIVTGSFDK 159 Query: 148 CIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIG 207 K+WD + + + H ++ C++ +P + ++ + S DN LWD + + + Sbjct: 160 TCKLWDAYTGQLYYTLKGHQTEIVCLSFNP-QSTIIATGSMDNTAKLWDVETGQERATLA 218 Query: 208 CSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHS 267 SL ++ ++ V G + L D ++ CV + H V+ F+ ++ Sbjct: 219 --GHRAEIVSLGFNT-GGDLIVTGSFDHDSRLWDVRTGQCVHVLSGHRGEVSSTQFN-YA 274 Query: 268 VPFLASLSEDCSLAVLDSSLSELFRS-QAHRDFVRDATWSPLNHSLLTTVGWDHQVVHHV 326 + S S DC+ + D Q H D V D + + + + D + Sbjct: 275 GTLVVSGSIDCTSRLWDVRSGRCLSVKQGHTDEVLDVAFD-AAGTKMVSASADGSARLYH 333 Query: 327 VPT 329 T Sbjct: 334 TLT 336 Score = 172 bits (435), Expect = 2e-43, Method: Composition-based stats. Identities = 42/232 (18%), Positives = 78/232 (33%), Gaps = 11/232 (4%) Query: 92 RGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKV 151 I+ S +LW+ + K H + +S T +GS D K+ Sbjct: 150 DKIVTGSFDKTCKLWDAYTGQLYYTLK----GHQTEIVCLSFNPQSTIIATGSMDNTAKL 205 Query: 152 WDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAP 211 WD+ ++ H A++ + + + ++ S D+ LWD R + + Sbjct: 206 WDVETGQERATLAGHRAEIVSLGFNT-GGDLIVTGSFDHDSRLWDVRTGQCVHVLSGHRG 264 Query: 212 GYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFL 271 T + + V G + T L D +S C+ H+ V + F + Sbjct: 265 EVSSTQFNYA---GTLVVSGSIDCTSRLWDVRSGRCLSVKQGHTDEVLDVAFDAAGTKMV 321 Query: 272 ASLSEDCSLAVLDSSLSELFRSQ-AHRDFVRDATWSPLNHSLLTTVGWDHQV 322 S S D S + + + H + ++P + L T D Sbjct: 322 -SASADGSARLYHTLTGVCQHTLVGHEGEISKVAFNPQ-GTRLITASSDKTC 371 Score = 170 bits (431), Expect = 6e-43, Method: Composition-based stats. Identities = 39/230 (16%), Positives = 86/230 (37%), Gaps = 11/230 (4%) Query: 94 ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWD 153 I S +LW+++ + + H + ++ + G V+GS D ++WD Sbjct: 194 IATGSMDNTAKLWDVETGQE----RATLAGHRAEIVSLGFNTGGDLIVTGSFDHDSRLWD 249 Query: 154 LAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGY 213 + + H +V+ + + ++ +S S D LWD R + S Sbjct: 250 VRTGQCVHVLSGHRGEVSSTQFN-YAGTLVVSGSIDCTSRLWDVRSGRCLSV--KQGHTD 306 Query: 214 LPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLAS 273 +A+ +++ V +G+ L T + C + H ++ + F+P + + Sbjct: 307 EVLDVAFDAAGTKM-VSASADGSARLYHTLTGVCQHTLVGHEGEISKVAFNPQGTRLI-T 364 Query: 274 LSEDCSLAVLDSSLSELFR-SQAHRDFVRDATWSPLNHSLLTTVGWDHQV 322 S D + + D E + + H D + ++ + T D+ Sbjct: 365 ASSDKTCRLWDCDTGECLQVLEGHTDEIFSCAFN-YEGDFIITGSKDNTC 413 Score = 159 bits (402), Expect = 2e-39, Method: Composition-based stats. Identities = 41/195 (21%), Positives = 74/195 (37%), Gaps = 9/195 (4%) Query: 89 VGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDIC 148 G I+ S LW++ + + V H VS+ +GT VSGS D Sbjct: 231 TGGDLIVTGSFDHDSRLWDVRTGQCVHV----LSGHRGEVSSTQFNYAGTLVVSGSIDCT 286 Query: 149 IKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGC 208 ++WD+ LS + H +V VA + +S S D L+ T + Sbjct: 287 SRLWDVRSGRCLSVKQGHTDEVLDVAFDAA-GTKMVSASADGSARLYHTLTGVCQHTLVG 345 Query: 209 SAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSV 268 +A++PQ + + + T L D + C+ H+ + F+ + Sbjct: 346 HEGEISK--VAFNPQGTRLI-TASSDKTCRLWDCDTGECLQVLEGHTDEIFSCAFN-YEG 401 Query: 269 PFLASLSEDCSLAVL 283 F+ + S+D + + Sbjct: 402 DFIITGSKDNTCRIW 416 Score = 99.0 bits (245), Expect = 2e-21, Method: Composition-based stats. Identities = 26/129 (20%), Positives = 51/129 (39%), Gaps = 7/129 (5%) Query: 69 NEGFCSAGVQTEA-GVADLTW-VGERGILVASDSGAVELWELDENETLIVSKFCKYEHDD 126 G C + Q V D+ + ++ AS G+ L+ V + H+ Sbjct: 293 RSGRCLSVKQGHTDEVLDVAFDAAGTKMVSASADGSARLYHTLTG----VCQHTLVGHEG 348 Query: 127 IVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSC 186 +S V+ GT+ ++ S D ++WD L H ++ A + ++ ++ Sbjct: 349 EISKVAFNPQGTRLITASSDKTCRLWDCDTGECLQVLEGHTDEIFSCAFN-YEGDFIITG 407 Query: 187 SEDNRILLW 195 S+DN +W Sbjct: 408 SKDNTCRIW 416 Score = 53.6 bits (127), Expect = 1e-07, Method: Composition-based stats. Identities = 13/76 (17%), Positives = 28/76 (36%), Gaps = 2/76 (2%) Query: 249 LSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSE-LFRSQAHRDFVRDATWSP 307 H +T F+ F+ + S D + V ++ E +F + H++ V ++ Sbjct: 88 KVLRAHILPLTNCAFNKSGDRFI-TGSYDRTCKVWNTFTGEEVFTLEGHKNVVYAIAFNN 146 Query: 308 LNHSLLTTVGWDHQVV 323 + T +D Sbjct: 147 PYGDKIVTGSFDKTCK 162 >2H9P-A nrPDB Length = 329 Score = 203 bits (516), Expect = 1e-52, Method: Composition-based stats. Identities = 51/235 (21%), Positives = 93/235 (39%), Gaps = 11/235 (4%) Query: 80 EAGVADLTWVGERGILV-ASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGT 138 + G++D+ W + +LV ASD +++W++ + L K H + V + Sbjct: 82 KLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLK----GHSNYVFCCNFNPQSN 137 Query: 139 QAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTR 198 VSGS D +++WD+ L + AH+ V+ V + S+ +S S D +WDT Sbjct: 138 LIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN-RDGSLIVSSSYDGLCRIWDTA 196 Query: 199 CPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCV 258 + + P S + + + T+ L D C+ + H Sbjct: 197 SGQCLKTLIDD--DNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEK 254 Query: 259 TGL--VFSPHSVPFLASLSEDCSLAVLDSSLSEL-FRSQAHRDFVRDATWSPLNH 310 + FS ++ S SED + + + E+ + Q H D V P + Sbjct: 255 YCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTEN 309 Score = 162 bits (411), Expect = 1e-40, Method: Composition-based stats. Identities = 47/243 (19%), Positives = 101/243 (41%), Gaps = 13/243 (5%) Query: 94 ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWD 153 + +S +++W + + + H +S V+ S VS S D +K+WD Sbjct: 55 LASSSADKLIKIWGAYDGK----FEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWD 110 Query: 154 LAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGY 213 ++ L + + H+ V C +P + ++ +S S D + +WD + K + A Sbjct: 111 VSSGKCLKTLKGHSNYVFCCNFNP-QSNLIVSGSFDESVRIWDVKTGKCLKTL--PAHSD 167 Query: 214 LPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQ-CVTGLVFSPHSVPFLA 272 +++ ++ + + V +G + DT S C+ + V+ + FSP+ LA Sbjct: 168 PVSAVHFN-RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILA 226 Query: 273 SLSEDCSLAVLDSSLSELFRS-QAH--RDFVRDATWSPLNHSLLTTVGWDHQVVHHVVPT 329 + D +L + D S + ++ H + A +S + + D+ V + T Sbjct: 227 AT-LDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQT 285 Query: 330 EPL 332 + + Sbjct: 286 KEI 288 Score = 157 bits (398), Expect = 5e-39, Method: Composition-based stats. Identities = 45/214 (21%), Positives = 83/214 (38%), Gaps = 8/214 (3%) Query: 112 ETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVT 171 + KF H VS+V +G S S D IK+W + H ++ Sbjct: 27 KPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGIS 86 Query: 172 CVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFG 231 VA S + + +S S+D + +WD K + ++PQ + + V G Sbjct: 87 DVAWSSDSN-LLVSASDDKTLKIWDVSSGKCLKTLK--GHSNYVFCCNFNPQSN-LIVSG 142 Query: 232 DENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELF 291 + +V + D K+ C+ + HS V+ + F+ + S S D + D++ + Sbjct: 143 SFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDG-SLIVSSSYDGLCRIWDTASGQCL 201 Query: 292 RSQAHRDF--VRDATWSPLNHSLLTTVGWDHQVV 323 ++ D V +SP N + D+ + Sbjct: 202 KTLIDDDNPPVSFVKFSP-NGKYILAATLDNTLK 234 Score = 80.9 bits (198), Expect = 7e-16, Method: Composition-based stats. Identities = 37/177 (20%), Positives = 73/177 (41%), Gaps = 24/177 (13%) Query: 31 LEAARYRSDGALLLGASSLSGRCWAGSLWLFKDPCAAPNEGFCSAGVQTEAG--VADLTW 88 + A + DG+L++ +SS G C +W G C + + V+ + + Sbjct: 169 VSAVHFNRDGSLIV-SSSYDGLC---RIWDTA-------SGQCLKTLIDDDNPPVSFVKF 217 Query: 89 VGE-RGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTV--SVLSSG-TQAVSGS 144 + IL A+ ++LW+ + + L H + + + +G VSGS Sbjct: 218 SPNGKYILAATLDNTLKLWDYSKGKCLKTY----TGHKNEKYCIFANFSVTGGKWIVSGS 273 Query: 145 KDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSE--DNRILLWDTRC 199 +D + +W+L + ++ + H V A P ++ + S + D I LW + C Sbjct: 274 EDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTEN-IIASAALENDKTIKLWKSDC 329 >1VYH-C nrPDB Length = 410 Score = 201 bits (510), Expect = 5e-52, Method: Composition-based stats. Identities = 52/262 (19%), Positives = 104/262 (39%), Gaps = 30/262 (11%) Query: 83 VADLTWVGERGILVA-SDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAV 141 V D+++ +L + S ++LW+ E + HD VS+VS++ +G V Sbjct: 153 VQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMH----GHDHNVSSVSIMPNGDHIV 208 Query: 142 SGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPK 201 S S+D IK+W++ + ++ H V V + ++ SCS D + +W + Sbjct: 209 SASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQD-GTLIASCSNDQTVRVWVVATKE 267 Query: 202 PASQIGCSAPGYLPTSLAWHPQQ-------------------SEVFVFGDENGTVSLVDT 242 +++ ++ ++W P+ + G + T+ + D Sbjct: 268 CKAELRE--HRHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDV 325 Query: 243 KSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRS-QAHRDFVR 301 + C+++ H V G++F F+ S ++D +L V D ++ AH FV Sbjct: 326 STGMCLMTLVGHDNWVRGVLFH-SGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVT 384 Query: 302 DATWSPLNHSLLTTVGWDHQVV 323 + + T D V Sbjct: 385 SLDFH-KTAPYVVTGSVDQTVK 405 Score = 152 bits (383), Expect = 2e-37, Method: Composition-based stats. Identities = 47/250 (18%), Positives = 89/250 (35%), Gaps = 36/250 (14%) Query: 58 LWLFKDPCAAPNEGFCSAGVQ-TEAGVADLTWVGE-RGILVASDSGAVELWELDENETLI 115 LW F+ C + + V+ ++ + I+ AS +++WE+ + Sbjct: 176 LWDFQGFE-------CIRTMHGHDHNVSSVSIMPNGDHIVSASRDKTIKMWEVQTGYCVK 228 Query: 116 VSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAA 175 H + V V GT S S D ++VW +A + + R H V C++ Sbjct: 229 TF----TGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHRHVVECISW 284 Query: 176 SPHKDS-------------------VFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPT 216 +P LS S D I +WD + Sbjct: 285 APESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLV--GHDNWVR 342 Query: 217 SLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSE 276 + +H + + ++ T+ + D K+ C+ + H VT L F + P++ + S Sbjct: 343 GVLFHS-GGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTA-PYVVTGSV 400 Query: 277 DCSLAVLDSS 286 D ++ V + Sbjct: 401 DQTVKVWECR 410 Score = 150 bits (378), Expect = 9e-37, Method: Composition-based stats. Identities = 43/205 (20%), Positives = 78/205 (38%), Gaps = 6/205 (2%) Query: 115 IVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVA 174 K+ H V+ V + VS S+D IKVWD + + H V ++ Sbjct: 98 PPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDIS 157 Query: 175 ASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDEN 234 H + SCS D I LWD + + + + +S++ P V + Sbjct: 158 FD-HSGKLLASCSADMTIKLWDFQGFECIRTM--HGHDHNVSSVSIMPNGDH-IVSASRD 213 Query: 235 GTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSEL-FRS 293 T+ + + ++ CV + H + V + + +AS S D ++ V + E Sbjct: 214 KTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGT-LIASCSNDQTVRVWVVATKECKAEL 272 Query: 294 QAHRDFVRDATWSPLNHSLLTTVGW 318 + HR V +W+P + + Sbjct: 273 REHRHVVECISWAPESSYSSISEAT 297 >6EOJ-D nrPDB Length = 470 Score = 198 bits (504), Expect = 2e-51, Method: Composition-based stats. Identities = 64/245 (26%), Positives = 105/245 (42%), Gaps = 12/245 (4%) Query: 86 LTWVGE-RGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGS 144 + W E R ++VA+ SG LW N + + HD V+T+ +SG Sbjct: 99 IQWTPEGRRLVVATYSGEFSLW----NASSFTFETLMQAHDSAVTTMKYSHDSDWMISGD 154 Query: 145 KDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPAS 204 D IK+W +V AH + +A S + DS F++CS+DN + +W+ K Sbjct: 155 ADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSN-DSKFVTCSDDNILKIWNFSNGKQER 213 Query: 205 QIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFS 264 + S + S WHP+ + ++ V L D +S +C+ S V F Sbjct: 214 VL--SGHHWDVKSCDWHPEMG-LIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQ 270 Query: 265 PHSVPFLASLSEDCSLAVLDSS--LSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQV 322 P L ++S+D S V D + EL + D++ W P+N S+ T +D + Sbjct: 271 PTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMT-LEWHPINESMFTLACYDGSL 329 Query: 323 VHHVV 327 H + Sbjct: 330 KHFDL 334 Score = 115 bits (287), Expect = 3e-26, Method: Composition-based stats. Identities = 46/249 (18%), Positives = 87/249 (34%), Gaps = 31/249 (12%) Query: 39 DGALLLGASSLSGRCWAGSLWLFKDPCAAPNEGFCSAGVQTEAGVADLTWV-GERGILVA 97 DG + + + S + K+ AA E + D+ + + + Sbjct: 156 DGMIKIWQPNFS---------MVKEIDAAHTES-----------IRDMAFSSNDSKFVTC 195 Query: 98 SDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQ 157 SD +++W + V H V + S SKD +K+WD Sbjct: 196 SDDNILKIWNFSNGKQERVLS----GHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSG 251 Query: 158 VVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTS 217 +SS V P K ++ ++ S+D ++D R Y+ Sbjct: 252 NCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMT-- 309 Query: 218 LAWHPQQSEVFVFGDENGTVSLVDTKST--SCVLSSA-VHSQCVTGLVFSPHSVPFLASL 274 L WHP +F +G++ D +L+ H +C+T L ++P A+ Sbjct: 310 LEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGH-IFATA 368 Query: 275 SEDCSLAVL 283 ++D ++ Sbjct: 369 AKDRTIRFW 377 >5NZU-C nrPDB Length = 905 Score = 196 bits (497), Expect = 2e-50, Method: Composition-based stats. Identities = 49/252 (19%), Positives = 105/252 (41%), Gaps = 19/252 (7%) Query: 72 FCSAGVQTEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTV 131 C V+ VA W ++ +D + ++ + E + + + H D + + Sbjct: 55 VCDLPVRAAKFVARKNW-----VVTGADDMQIRVFNYNTLERVHMFE----AHSDYIRCI 105 Query: 132 SVLSSGTQAVSGSKDICIKVWDLAQQV-VLSSYRAHAAQVTCVAASPHKDSVFLSCSEDN 190 +V + ++ S D+ IK+WD ++ + H V + +P ++ F S S D Sbjct: 106 AVHPTQPFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDR 165 Query: 191 RILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQ-QSEVFVFGDENGTVSLVDTKSTSCVL 249 I +W P + G + ++ + G ++ V + D ++ +CV Sbjct: 166 TIKVWQLGSSSPNFTLEGHEKG--VNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQ 223 Query: 250 SSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHRDFVRDATW--SP 307 + H+Q V+ F P +P + + SED ++ + SS +R ++ ++ + W + Sbjct: 224 TLEGHAQNVSCASFHP-ELPIIITGSEDGTVRIWHSST---YRLESTLNYGMERVWCVAS 279 Query: 308 LNHSLLTTVGWD 319 L S +G+D Sbjct: 280 LRGSNNVALGYD 291 Score = 97.1 bits (240), Expect = 9e-21, Method: Composition-based stats. Identities = 25/168 (14%), Positives = 57/168 (33%), Gaps = 9/168 (5%) Query: 159 VLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIG-CSAPGYLPTS 217 + A + +V V P + + S + + +W+ C P Sbjct: 7 IKRKLTARSDRVKSVDLHPTEPWMLASL-YNGSVCVWNHETQTLVKTFEVCDLPVRAAKF 65 Query: 218 LAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSED 277 +A + V G ++ + + + + V HS + + P PF+ + S+D Sbjct: 66 VA----RKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQ-PFILTSSDD 120 Query: 278 CSLAVLDS--SLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQVV 323 + + D S + H +V +P +++ + D + Sbjct: 121 MLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIK 168 >6F3T-A nrPDB Length = 608 Score = 194 bits (493), Expect = 5e-50, Method: Composition-based stats. Identities = 53/270 (19%), Positives = 89/270 (32%), Gaps = 35/270 (12%) Query: 82 GVADLTWVGERGILVAS-DSGAVELWELDENETLIVSKFCK------------------- 121 G+ + + ++ V +W + + V + Sbjct: 280 GLTAVDVTDDSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESDDVLERIMDEK 339 Query: 122 --------YEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCV 173 Y H V S +S S+D +++W L L Y+ H V Sbjct: 340 TASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDT 399 Query: 174 AASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDE 233 SP+ F+S D LW T +P +HP + V G Sbjct: 400 QFSPY-GYYFVSGGHDRVARLWATDHYQPLRIFAGHLAD--VNCTRFHPNSNYV-ATGSA 455 Query: 234 NGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELF-R 292 + TV L D + +CV H + L FSP+ FLA+ + D + + D + Sbjct: 456 DRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNG-RFLATGATDGRVLLWDIGHGLMVGE 514 Query: 293 SQAHRDFVRDATWSPLNHSLLTTVGWDHQV 322 + H D V +S + +L + D+ V Sbjct: 515 LKGHTDTVCSLRFS-RDGEILASGSMDNTV 543 Score = 104 bits (258), Expect = 7e-23, Method: Composition-based stats. Identities = 22/117 (18%), Positives = 45/117 (38%), Gaps = 6/117 (5%) Query: 81 AGVADLTWVGERGIL-VASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQ 139 A V + + S V LW++ + + H + +++ +G Sbjct: 436 ADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIF----TGHKGPIHSLTFSPNGRF 491 Query: 140 AVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWD 196 +G+ D + +WD+ +++ + H V + S + S S DN + LWD Sbjct: 492 LATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFS-RDGEILASGSMDNTVRLWD 547 >5NNZ-B nrPDB Length = 415 Score = 194 bits (492), Expect = 6e-50, Method: Composition-based stats. Identities = 40/232 (17%), Positives = 90/232 (38%), Gaps = 11/232 (4%) Query: 92 RGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKV 151 I S +LW ++ + + H + +S T +GS D K+ Sbjct: 148 DKIATGSFDKTCKLWSVETGKCYHTFR----GHTAEIVCLSFNPQSTLVATGSMDTTAKL 203 Query: 152 WDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAP 211 WD+ + + R H+A++ ++ + D + ++ S D+ +++WD + + + Sbjct: 204 WDIQNGEEVYTLRGHSAEIISLSFNTSGDRI-ITGSFDHTVVVWDADTGRKVNILIGHCA 262 Query: 212 GYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFL 271 S W + + G + T L D + CV + H + F ++ + Sbjct: 263 EISSASFNW---DCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCF-DYTGKLI 318 Query: 272 ASLSEDCSLAVLDSSLSELF-RSQAHRDFVRDATWSPLNHSLLTTVGWDHQV 322 A+ S D + + ++ + + + H + +++P + LL T D Sbjct: 319 ATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLL-TGSSDKTA 369 Score = 155 bits (391), Expect = 3e-38, Method: Composition-based stats. Identities = 47/216 (21%), Positives = 84/216 (38%), Gaps = 7/216 (3%) Query: 109 DENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAA 168 + N T + K K H ++ V++ SG+ ++GS D K+WD A L++ H Sbjct: 77 NSNHTFYLFKVLK-AHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRN 135 Query: 169 QVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVF 228 V +A + + S D LW K L+++PQ + + Sbjct: 136 VVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFR--GHTAEIVCLSFNPQST-LV 192 Query: 229 VFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLS 288 G + T L D ++ V + HS + L F+ S + + S D ++ V D+ Sbjct: 193 ATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFN-TSGDRIITGSFDHTVVVWDADTG 251 Query: 289 ELFRSQ-AHRDFVRDATWSPLNHSLLTTVGWDHQVV 323 H + A+++ + SL+ T D Sbjct: 252 RKVNILIGHCAEISSASFN-WDCSLILTGSMDKTCK 286 Score = 152 bits (384), Expect = 2e-37, Method: Composition-based stats. Identities = 28/195 (14%), Positives = 72/195 (36%), Gaps = 9/195 (4%) Query: 89 VGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDIC 148 I+ S V +W+ D + + H +S+ S + ++GS D Sbjct: 229 TSGDRIITGSFDHTVVVWDADTGRKVNI----LIGHCAEISSASFNWDCSLILTGSMDKT 284 Query: 149 IKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGC 208 K+WD +++ H ++ + + + S D ++ K +++ Sbjct: 285 CKLWDATNGKCVATLTGHDDEILDSCFD-YTGKLIATASADGTARIFSAATRKCIAKLEG 343 Query: 209 SAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSV 268 ++++PQ + + G + T + D ++ C+ H+ + F+ + Sbjct: 344 HEGEISK--ISFNPQGNHLL-TGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFN-YKG 399 Query: 269 PFLASLSEDCSLAVL 283 + + S+D + + Sbjct: 400 NIVITGSKDNTCRIW 414 Score = 54.0 bits (128), Expect = 9e-08, Method: Composition-based stats. Identities = 14/82 (17%), Positives = 30/82 (36%), Gaps = 2/82 (2%) Query: 249 LSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRS-QAHRDFVRDATWSP 307 H +T + + F+ + S D + + D++ E + + HR+ V ++ Sbjct: 86 KVLKAHILPLTNVALNKSGSCFI-TGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNN 144 Query: 308 LNHSLLTTVGWDHQVVHHVVPT 329 + T +D V T Sbjct: 145 PYGDKIATGSFDKTCKLWSVET 166 >6HQA-B nrPDB Length = 722 Score = 193 bits (489), Expect = 1e-49, Method: Composition-based stats. Identities = 58/255 (22%), Positives = 92/255 (36%), Gaps = 29/255 (11%) Query: 90 GERGILVASD--SGAVELWEL---------------DENETLIVSKFCKY--EHDDIVST 130 + +VAS ++LW + +N + K + H V Sbjct: 399 NDDSTMVASGFQDSFIKLWSIDGSPLRSLLKNDPYNQQNNDGVAVKGSRRLVGHSGAVYG 458 Query: 131 VSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDN 190 V +S S+D +++W L L SY+ H++ V V SP F + S D Sbjct: 459 VDFSPDNRYLISCSEDKTVRLWSLDTYTCLVSYKGHSSSVWDVKFSPM-GHYFATASHDQ 517 Query: 191 RILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLS 250 LW P + +HP + +F G + T + D CV Sbjct: 518 TARLWSCDHIYPLRIFAGHLND--VDCVEFHPNSTYLF-TGSSDKTARMWDIARGECVRV 574 Query: 251 SAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHRDFVRDATWS---P 307 HS + L SP +LAS ED + + D S R +A R R + +S Sbjct: 575 FMGHSGAINCLAVSPDG-RWLASAGEDSVVCLWDISTGR--RIKAMRGHGRSSIYSLAFS 631 Query: 308 LNHSLLTTVGWDHQV 322 ++L + G D+ V Sbjct: 632 REGTVLVSTGADNSV 646 Score = 102 bits (254), Expect = 2e-22, Method: Composition-based stats. Identities = 21/109 (19%), Positives = 46/109 (42%), Gaps = 6/109 (5%) Query: 94 ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWD 153 + S +W++ E + V H ++ ++V G S +D + +WD Sbjct: 552 LFTGSSDKTARMWDIARGECVRVFM----GHSGAINCLAVSPDGRWLASAGEDSVVCLWD 607 Query: 154 LAQQVVLSSYRAH-AAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPK 201 ++ + + R H + + +A S + +V +S DN + +WD + Sbjct: 608 ISTGRRIKAMRGHGRSSIYSLAFS-REGTVLVSTGADNSVRVWDVKKNT 655 Score = 56.3 bits (134), Expect = 2e-08, Method: Composition-based stats. Identities = 24/126 (19%), Positives = 45/126 (35%), Gaps = 19/126 (15%) Query: 36 YRSDGALLLGASSLSGRCWAGSLWLFKDPCAAPNEGFCSAGVQTEAG-VADLTWVGE-RG 93 + + L G+S + R W D G C +G + L + R Sbjct: 546 HPNSTYLFTGSSDKTARMW--------DIA----RGECVRVFMGHSGAINCLAVSPDGRW 593 Query: 94 ILVASDSGAVELWELDENETLIVSKFCKYEH-DDIVSTVSVLSSGTQAVSGSKDICIKVW 152 + A + V LW++ + + H + +++ GT VS D ++VW Sbjct: 594 LASAGEDSVVCLWDISTGRRIKAMR----GHGRSSIYSLAFSREGTVLVSTGADNSVRVW 649 Query: 153 DLAQQV 158 D+ + Sbjct: 650 DVKKNT 655 >6MZM-G nrPDB Length = 800 Score = 191 bits (486), Expect = 3e-49, Method: Composition-based stats. Identities = 49/203 (24%), Positives = 76/203 (37%), Gaps = 7/203 (3%) Query: 121 KYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKD 180 Y H V S +S S+D +++W L L Y+ H V SP+ Sbjct: 539 LYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPY-G 597 Query: 181 SVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLV 240 F+S D LW T +P +HP + V G + TV L Sbjct: 598 YYFVSGGHDRVARLWATDHYQPLRIFAGHLAD--VNCTRFHPNSNYV-ATGSADRTVRLW 654 Query: 241 DTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELF-RSQAHRDF 299 D + +CV H + L FSP+ FLA+ + D + + D + + H D Sbjct: 655 DVLNGNCVRIFTGHKGPIHSLTFSPNG-RFLATGATDGRVLLWDIGHGLMVGELKGHTDT 713 Query: 300 VRDATWSPLNHSLLTTVGWDHQV 322 V +S + +L + D+ V Sbjct: 714 VCSLRFS-RDGEILASGSMDNTV 735 Score = 127 bits (320), Expect = 5e-30, Method: Composition-based stats. Identities = 39/164 (23%), Positives = 60/164 (36%), Gaps = 7/164 (4%) Query: 161 SSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAW 220 H+ V + SP + LS SED + LW + +G Y + Sbjct: 537 KILYGHSGPVYGASFSPD-RNYLLSSSEDGTVRLWSLQTFTCL--VGYKGHNYPVWDTQF 593 Query: 221 HPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSL 280 P FV G + L T + A H V F P+S ++A+ S D ++ Sbjct: 594 SPY-GYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNS-NYVATGSADRTV 651 Query: 281 AVLDSSLSELFR-SQAHRDFVRDATWSPLNHSLLTTVGWDHQVV 323 + D R H+ + T+SP N L T D +V+ Sbjct: 652 RLWDVLNGNCVRIFTGHKGPIHSLTFSP-NGRFLATGATDGRVL 694 Score = 104 bits (259), Expect = 6e-23, Method: Composition-based stats. Identities = 22/117 (18%), Positives = 45/117 (38%), Gaps = 6/117 (5%) Query: 81 AGVADLTWVGERGIL-VASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQ 139 A V + + S V LW++ + + H + +++ +G Sbjct: 628 ADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIF----TGHKGPIHSLTFSPNGRF 683 Query: 140 AVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWD 196 +G+ D + +WD+ +++ + H V + S + S S DN + LWD Sbjct: 684 LATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFS-RDGEILASGSMDNTVRLWD 739 >3MKQ-A nrPDB Length = 814 Score = 190 bits (483), Expect = 7e-49, Method: Composition-based stats. Identities = 50/233 (21%), Positives = 101/233 (43%), Gaps = 15/233 (6%) Query: 94 ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWD 153 I+V SD + ++ + E ++ + H D + +++V + +SGS D+ +K+W+ Sbjct: 70 IIVGSDDFRIRVFNYNTGEKVVDFE----AHPDYIRSIAVHPTKPYVLSGSDDLTVKLWN 125 Query: 154 LAQQVVL-SSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPG 212 L ++ H V CVA +P S F S D + +W P + + Sbjct: 126 WENNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTL-TTGQE 184 Query: 213 YLPTSLAWHPQ-QSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFL 271 + ++P + ++ T+ + D ++ SCV + H V+ VF P ++P + Sbjct: 185 RGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAVFHP-TLPII 243 Query: 272 ASLSEDCSLAVLDSSLSELFRSQAHRDFVRDATW----SPLNHSLLTTVGWDH 320 S SED +L + +SS ++ + + + +W P G+D+ Sbjct: 244 ISGSEDGTLKIWNSST---YKVEKTLNVGLERSWCIATHPTGRKNYIASGFDN 293 Score = 31.6 bits (70), Expect = 0.44, Method: Composition-based stats. Identities = 17/109 (15%), Positives = 39/109 (35%), Gaps = 18/109 (16%) Query: 86 LTWVGERGILVASDSGAVELWELDENETLIVSKFCK---YEHDDIVST--VSVLSSGTQA 140 L W + +W D N ++ + + Y++ V++ V + S+ + Sbjct: 385 LAWRNKA--FGKCQDF---VWGPDSNSYALIDETGQIKYYKNFKEVTSWSVPMHSAIDRL 439 Query: 141 VSGS-----KDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFL 184 SG+ D + +D ++ +A V S + + V + Sbjct: 440 FSGALLGVKSDGFVYFFDWDNGTLVRRIDVNAKDVI---WSDNGELVMI 485 >6QX9-4B nrPDB Length = 522 Score = 187 bits (475), Expect = 5e-48, Method: Composition-based stats. Identities = 47/248 (18%), Positives = 90/248 (36%), Gaps = 18/248 (7%) Query: 90 GERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGT--------QAV 141 + + A SG +LW + + L + H+ V + T Sbjct: 242 NSKMLATACWSGLCKLWSVPDCNLLHTLR----GHNTNVGAIVFHPKSTVSLDPKDVNLA 297 Query: 142 SGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPK 201 S + D +K+W L ++ H +V V P + +C D LWD + Sbjct: 298 SCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTC-YDRSWRLWDLEAQE 356 Query: 202 PASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGL 261 + +A+H Q + G + + D ++ C++ H + + G+ Sbjct: 357 EI--LHQEGHSMGVYDIAFH-QDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGI 413 Query: 262 VFSPHSVPFLASLSEDCSLAVLDSSLSEL-FRSQAHRDFVRDATWSPLNHSLLTTVGWDH 320 FSP+ +A+ S D + V D + AH++ V + P++ + L T +D+ Sbjct: 414 NFSPNG-YHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDN 472 Query: 321 QVVHHVVP 328 P Sbjct: 473 TAKIWTHP 480 Score = 151 bits (381), Expect = 4e-37, Method: Composition-based stats. Identities = 54/247 (21%), Positives = 89/247 (36%), Gaps = 20/247 (8%) Query: 38 SDGALLLGASSLSGRCWAGSLWLFKDPCAAPNEGFCSAGVQTEAGVADLTWVGE-RGILV 96 D L A+ S + W+ L D A EG VA + W R + Sbjct: 292 KDVNLASCAADGSVKLWS----LDSDEPVADIEGHTVR-------VARVMWHPSGRFLGT 340 Query: 97 ASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQ 156 + LW+L+ E ++ + H V ++ G+ A +G D +VWDL Sbjct: 341 TCYDRSWRLWDLEAQEEILHQE----GHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRT 396 Query: 157 QVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPT 216 + H ++ + SP+ + S DN +WD R + I A L T Sbjct: 397 GRCIMFLEGHLKEIYGINFSPN-GYHIATGSGDNTCKVWDLRQRRCVYTI--PAHQNLVT 453 Query: 217 SLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSE 276 + + P + G + T + S + + A H V GL S +A+ S Sbjct: 454 GVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQ-LIATCSY 512 Query: 277 DCSLAVL 283 D + + Sbjct: 513 DRTFKLW 519 Score = 151 bits (381), Expect = 5e-37, Method: Composition-based stats. Identities = 48/233 (20%), Positives = 81/233 (34%), Gaps = 10/233 (4%) Query: 90 GERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICI 149 + + + G+V+LW LD +E + H V+ V SG + D Sbjct: 292 KDVNLASCAADGSVKLWSLDSDEPV----ADIEGHTVRVARVMWHPSGRFLGTTCYDRSW 347 Query: 150 KVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCS 209 ++WDL Q + H+ V +A S+ + D +WD R + + Sbjct: 348 RLWDLEAQEEILHQEGHSMGVYDIAFHQD-GSLAGTGGLDAFGRVWDLRTGRCIMFLE-- 404 Query: 210 APGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVP 269 + + P G + T + D + CV + H VTG+ F P Sbjct: 405 GHLKEIYGINFSPN-GYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGN 463 Query: 270 FLASLSEDCSLAVL-DSSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQ 321 FL + + D + + S L H V S + L+ T +D Sbjct: 464 FLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISS-DGQLIATCSYDRT 515 >2YNP-A nrPDB Length = 604 Score = 186 bits (472), Expect = 1e-47, Method: Composition-based stats. Identities = 50/233 (21%), Positives = 101/233 (43%), Gaps = 15/233 (6%) Query: 94 ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWD 153 I+V SD + ++ + E ++ + H D + +++V + +SGS D+ +K+W+ Sbjct: 70 IIVGSDDFRIRVFNYNTGEKVVDFE----AHPDYIRSIAVHPTKPYVLSGSDDLTVKLWN 125 Query: 154 LAQQVVL-SSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPG 212 L ++ H V CVA +P S F S D + +W P + + Sbjct: 126 WENNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTL-TTGQE 184 Query: 213 YLPTSLAWHPQ-QSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFL 271 + ++P + ++ T+ + D ++ SCV + H V+ VF P ++P + Sbjct: 185 RGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAVFHP-TLPII 243 Query: 272 ASLSEDCSLAVLDSSLSELFRSQAHRDFVRDATW----SPLNHSLLTTVGWDH 320 S SED +L + +SS ++ + + + +W P G+D+ Sbjct: 244 ISGSEDGTLKIWNSST---YKVEKTLNVGLERSWCIATHPTGRKNYIASGFDN 293 Score = 30.9 bits (68), Expect = 0.95, Method: Composition-based stats. Identities = 17/109 (15%), Positives = 39/109 (35%), Gaps = 18/109 (16%) Query: 86 LTWVGERGILVASDSGAVELWELDENETLIVSKFCK---YEHDDIVST--VSVLSSGTQA 140 L W + +W D N ++ + + Y++ V++ V + S+ + Sbjct: 385 LAWRNKA--FGKCQDF---VWGPDSNSYALIDETGQIKYYKNFKEVTSWSVPMHSAIDRL 439 Query: 141 VSGS-----KDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFL 184 SG+ D + +D ++ +A V S + + V + Sbjct: 440 FSGALLGVKSDGFVYFFDWDNGTLVRRIDVNAKDVI---WSDNGELVMI 485 >3DM0-A nrPDB Length = 694 Score = 175 bits (444), Expect = 2e-44, Method: Composition-based stats. Identities = 55/232 (23%), Positives = 96/232 (41%), Gaps = 10/232 (4%) Query: 90 GERGILVASDSGAVELWELDENETLI-VSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDIC 148 I+ AS ++ LW+L +++ V++ H V V + S G A+SGS D Sbjct: 394 NADIIVSASRDKSIILWKLTKDDKAYGVAQRRLTGHSHFVEDVVLSSDGQFALSGSWDGE 453 Query: 149 IKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGC 208 +++WDLA V + H V VA S + +S S D I LW+T + I Sbjct: 454 LRLWDLAAGVSTRRFVGHTKDVLSVAFSLDNRQI-VSASRDRTIKLWNT-LGECKYTISE 511 Query: 209 SAPGY--LPTSLAWHPQQ-SEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSP 265 G+ + + + P V + TV + + + + A H+ V+ + SP Sbjct: 512 GGEGHRDWVSCVRFSPNTLQPTIVSASWDKTVKVWNLSNCKLRSTLAGHTGYVSTVAVSP 571 Query: 266 HSVPFLASLSEDCSLAVLDSSL-SELFRSQAHRDFVRDATWSPLNHSLLTTV 316 AS +D + + D + +L+ +A+ + +SP N L Sbjct: 572 DG-SLCASGGKDGVVLLWDLAEGKKLYSLEANS-VIHALCFSP-NRYWLCAA 620 Score = 131 bits (329), Expect = 5e-31, Method: Composition-based stats. Identities = 62/280 (22%), Positives = 99/280 (35%), Gaps = 37/280 (13%) Query: 28 ERQLEAARYRSDGALLL--GASSLSGRCWAGSLWLFKDPCAAPNEGFCSAGVQTEAGVAD 85 +R+L + + +L G +LSG W G L L+ F V Sbjct: 423 QRRLTGHSHFVEDVVLSSDGQFALSG-SWDGELRLWDLAAGVSTRRFVGHTKD----VLS 477 Query: 86 LTWV-GERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSS--GTQAVS 142 + + R I+ AS ++LW E H D VS V + VS Sbjct: 478 VAFSLDNRQIVSASRDRTIKLWNTL-GECKYTISEGGEGHRDWVSCVRFSPNTLQPTIVS 536 Query: 143 GSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKP 202 S D +KVW+L+ + S+ H V+ VA SP S+ S +D +LLWD K Sbjct: 537 ASWDKTVKVWNLSNCKLRSTLAGHTGYVSTVAVSPD-GSLCASGGKDGVVLLWDLAEGKK 595 Query: 203 ASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQC----- 257 + ++ + +L + P + ++ + + D +S S V V + Sbjct: 596 LYSLEANSVIH---ALCFSP--NRYWLCAATEHGIKIWDLESKSIVEDLKVDLKAEAEKA 650 Query: 258 --------------VTGLVFSPHSVPFLASLSEDCSLAVL 283 T L +S L S D + V Sbjct: 651 DNSGPAATKRKVIYCTSLNWSADGST-LFSGYTDGVIRVW 689 Score = 124 bits (312), Expect = 4e-29, Method: Composition-based stats. Identities = 53/221 (23%), Positives = 86/221 (38%), Gaps = 18/221 (8%) Query: 115 IVSKFCKYEHDDIVSTVSV-LSSGTQAVSGSKDICIKVW-----DLAQQVVLSSYRAHAA 168 +V K H D+V+ ++ + + VS S+D I +W D A V H+ Sbjct: 372 LVLKGTMRAHTDMVTAIATPIDNADIIVSASRDKSIILWKLTKDDKAYGVAQRRLTGHSH 431 Query: 169 QVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVF 228 V V S LS S D + LWD + S+A+ + Sbjct: 432 FVEDVVLSSD-GQFALSGSWDGELRLWDLAAGVSTRRFV--GHTKDVLSVAF-SLDNRQI 487 Query: 229 VFGDENGTVSLVDTKSTSCVLSS----AVHSQCVTGLVFSPHSV-PFLASLSEDCSLAVL 283 V + T+ L +T C + H V+ + FSP+++ P + S S D ++ V Sbjct: 488 VSASRDRTIKLWNTL-GECKYTISEGGEGHRDWVSCVRFSPNTLQPTIVSASWDKTVKVW 546 Query: 284 DSSLSEL-FRSQAHRDFVRDATWSPLNHSLLTTVGWDHQVV 323 + S +L H +V SP + SL + G D V+ Sbjct: 547 NLSNCKLRSTLAGHTGYVSTVAVSP-DGSLCASGGKDGVVL 586 >4V6W-Ag nrPDB Length = 318 Score = 173 bits (437), Expect = 1e-43, Method: Composition-based stats. Identities = 48/222 (21%), Positives = 85/222 (38%), Gaps = 6/222 (2%) Query: 89 VGERGILVASDSGAVELWELDENE--TLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKD 146 I+ AS + +W+L +E + Y H +S V + S G A+SGS D Sbjct: 26 KDPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRLYGHSHFISDVVLSSDGNYALSGSWD 85 Query: 147 ICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQI 206 +++WDLA + H V VA S + +S S D I LW+T + I Sbjct: 86 QTLRLWDLAAGKTTRRFEGHTKDVLSVAFSADNRQI-VSGSRDKTIKLWNTLA-ECKFTI 143 Query: 207 GCSAPGYLPTSLAWHP-QQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSP 265 + + + P + + V + TV + + + + H+ + + SP Sbjct: 144 QEDGHTDWVSCVRFSPNHSNPIIVSCGWDRTVKVWNLANCKLKNNHHGHNGYLNTVTVSP 203 Query: 266 HSVPFLASLSEDCSLAVLDSSLSELFRSQAHRDFVRDATWSP 307 S +D + D + + + H D + +SP Sbjct: 204 DG-SLCTSGGKDSKALLWDLNDGKNLYTLEHNDIINALCFSP 244 Score = 121 bits (304), Expect = 3e-28, Method: Composition-based stats. Identities = 35/178 (19%), Positives = 68/178 (38%), Gaps = 13/178 (7%) Query: 155 AQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLW------DTRCPKPASQIGC 208 + + H VT +A +P +S S D +++W DT P ++ Sbjct: 3 ETLQLRGTLIGHNGWVTQIATNPKDPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRLYG 62 Query: 209 SAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSV 268 + L+ + G + T+ L D + H++ V + FS + Sbjct: 63 HSHFISDVVLS---SDGNYALSGSWDQTLRLWDLAAGKTTRRFEGHTKDVLSVAFSADN- 118 Query: 269 PFLASLSEDCSLAVLDSSLSELFRSQ--AHRDFVRDATWSP-LNHSLLTTVGWDHQVV 323 + S S D ++ + ++ F Q H D+V +SP ++ ++ + GWD V Sbjct: 119 RQIVSGSRDKTIKLWNTLAECKFTIQEDGHTDWVSCVRFSPNHSNPIIVSCGWDRTVK 176 Score = 51.7 bits (122), Expect = 5e-07, Method: Composition-based stats. Identities = 25/123 (20%), Positives = 45/123 (36%), Gaps = 17/123 (13%) Query: 83 VADLTWVGERGIL-VASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAV 141 + +T + + LW+L++ + L EH+DI++ + + Sbjct: 196 LNTVTVSPDGSLCTSGGKDSKALLWDLNDGKNLYT-----LEHNDIINALCFSPNRYWLC 250 Query: 142 SGSKDICIKVWDLAQQVVLSSYR---------AHAAQVTCVAASPHKDSVFLSCSEDNRI 192 IK+WDLA + + R A Q +A S ++F DN I Sbjct: 251 VAYG-PSIKIWDLACKKTVEELRPEVVSPTSKADQPQCLSLAWSTDGQTLFA-GYSDNTI 308 Query: 193 LLW 195 +W Sbjct: 309 RVW 311 Score = 36.3 bits (82), Expect = 0.023, Method: Composition-based stats. Identities = 24/144 (16%), Positives = 51/144 (35%), Gaps = 7/144 (4%) Query: 17 WNLPPNAPACMERQLEAARYRSDGALLLGASSLSGRCWAGSLWLFKDPCAAPNEGFCSAG 76 W+ +L+ + +G L S G K N+G Sbjct: 171 WDRTVKVWNLANCKLKNNHHGHNGYLNTVTVSPDGSLCTSGGKDSKALLWDLNDGKNLYT 230 Query: 77 VQTEAGVADLTWVGERGILVASDSGAVELWELDENET------LIVSKFCKYEHDDIVST 130 ++ + L + R L + ++++W+L +T +VS K + + + Sbjct: 231 LEHNDIINALCFSPNRYWLCVAYGPSIKIWDLACKKTVEELRPEVVSPTSKADQPQCL-S 289 Query: 131 VSVLSSGTQAVSGSKDICIKVWDL 154 ++ + G +G D I+VW + Sbjct: 290 LAWSTDGQTLFAGYSDNTIRVWQV 313 >3JRO-A nrPDB Length = 753 Score = 171 bits (434), Expect = 3e-43, Method: Composition-based stats. Identities = 45/236 (19%), Positives = 86/236 (36%), Gaps = 25/236 (10%) Query: 123 EHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLA--QQVVLSSYRAHAAQVTCVAA-SPHK 179 H++++ + G + + S D IK++++ ++ + H V V P Sbjct: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKF 66 Query: 180 DSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQ-SEVFVFGDENGTVS 238 ++ SCS D ++L+W + + + S+ W P + + + +G VS Sbjct: 67 GTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVS 126 Query: 239 LVDTKSTSCVLS--SAVHSQCVTGLVFSPH------------SVPFLASLSEDCSLAVL- 283 +V+ K H+ V ++P + D + + Sbjct: 127 VVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWK 186 Query: 284 ---DSSLSELFRS-QAHRDFVRDATWSP--LNHSLLTTVGWDHQVVHHVVPTEPLP 333 D+ L + + H D+VRD WSP L S L +V D + E P Sbjct: 187 YNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGP 242 Score = 65.1 bits (157), Expect = 4e-11, Method: Composition-based stats. Identities = 21/115 (18%), Positives = 40/115 (34%), Gaps = 9/115 (7%) Query: 92 RGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSS---GTQAVSGSKDIC 148 R + V++W+ + + V + H D V V+ + + S S+D Sbjct: 171 RKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRT 230 Query: 149 IKVW--DLAQQVVLSSYRAHA---AQVTCVAASPHKDSVFLSCSEDNRILLWDTR 198 +W D Q + + + S + + LS DN++ LW Sbjct: 231 CIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGG-DNKVTLWKEN 284 >4L9O-A nrPDB Length = 349 Score = 171 bits (433), Expect = 4e-43, Method: Composition-based stats. Identities = 52/218 (23%), Positives = 88/218 (40%), Gaps = 17/218 (7%) Query: 123 EHDDIVSTVSVLSSGTQAVSGSKDICIKVWDL--AQQVVLSSYRAHAAQVTCVAA-SPHK 179 HDD++ + G + + S D IK++++ Q ++ + H V VA P Sbjct: 67 AHDDLIHDAVLDYYGRRLATCSSDKTIKIFEIDGENQRLVETLIGHEGPVWQVAWAHPKF 126 Query: 180 DSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQ-SEVFVFGDENGTVS 238 + SCS D ++L+W S S++W P + V + +G +S Sbjct: 127 GVILASCSYDGKVLIWKEDNGVWNKVAEHSVHQASVNSVSWAPHEYGPVLLCASSDGKIS 186 Query: 239 LVDTKSTSCVLS--SAVHSQCVTGLVFSPHSVP----FLASLSEDCSLAVL--DSSLS-- 288 +V+ K + H+ V ++P S+P S D + + D + Sbjct: 187 IVEFKDGGALEPIVIQGHAIGVNAASWAPISLPDNTRRFVSGGCDNLVKIWRYDDAAKTF 246 Query: 289 -ELFRSQAHRDFVRDATWSP--LNHSLLTTVGWDHQVV 323 E Q H D+VRD WSP L+ S + T D V+ Sbjct: 247 IEEEAFQGHSDWVRDVAWSPSRLSKSYIATASQDRTVL 284 Score = 90.6 bits (223), Expect = 9e-19, Method: Composition-based stats. Identities = 43/252 (17%), Positives = 75/252 (29%), Gaps = 23/252 (9%) Query: 67 APNEGFCSAGVQTEAGVADLTWVGERG---ILVASDSGAVELWELDENETLIVSKFCKYE 123 N+ + E V + W + + S G V +W+ D V++ Sbjct: 100 GENQRLVETLIGHEGPVWQVAWAHPKFGVILASCSYDGKVLIWKEDNGVWNKVAEHSV-- 157 Query: 124 HDDIVSTVSVLS--SGTQAVSGSKDICIKVWDLAQQVVLS--SYRAHAAQVTCVAAS--- 176 H V++VS G + S D I + + L + HA V + + Sbjct: 158 HQASVNSVSWAPHEYGPVLLCASSDGKISIVEFKDGGALEPIVIQGHAIGVNAASWAPIS 217 Query: 177 -PHKDSVFLSCSEDNRILLW--DTRCPKPASQIGCSAPGYLPTSLAWHP--QQSEVFVFG 231 P F+S DN + +W D + +AW P Sbjct: 218 LPDNTRRFVSGGCDNLVKIWRYDDAAKTFIEEEAFQGHSDWVRDVAWSPSRLSKSYIATA 277 Query: 232 DENGTVSLV--DTKST---SCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSS 286 ++ TV + D KS L+ +S S D + + + Sbjct: 278 SQDRTVLIWTKDGKSNKWEKQPLTKEKFPDVCWRASWSLSGNVLAISGG-DNKVTLWKEN 336 Query: 287 LSELFRSQAHRD 298 + + S D Sbjct: 337 IQGKWESAGEVD 348 >6G51-g nrPDB Length = 317 Score = 171 bits (432), Expect = 5e-43, Method: Composition-based stats. Identities = 49/229 (21%), Positives = 87/229 (37%), Gaps = 5/229 (2%) Query: 91 ERGILVASDSGAVELWELDENETLI-VSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICI 149 IL AS + +W+L +ET + + H VS V + S G A+SGS D + Sbjct: 28 PDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTL 87 Query: 150 KVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCS 209 ++WDL + H V VA S + +S S D I LW+T + Sbjct: 88 RLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQI-VSGSRDKTIKLWNT-LGVCKYTVQDE 145 Query: 210 APGYLPTSLAWHPQ-QSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSV 268 + + + + P + + V + V + + + + H+ + + SP Sbjct: 146 SHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDG- 204 Query: 269 PFLASLSEDCSLAVLDSSLSELFRSQAHRDFVRDATWSPLNHSLLTTVG 317 AS +D + D + + + D + +SP + L G Sbjct: 205 SLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATG 253 Score = 117 bits (293), Expect = 6e-27, Method: Composition-based stats. Identities = 33/175 (18%), Positives = 71/175 (40%), Gaps = 8/175 (4%) Query: 155 AQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDT---RCPKPASQIGCSAP 211 Q + + + H VT +A +P + LS S D I++W Q Sbjct: 3 EQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGH 62 Query: 212 GYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFL 271 + + + + + G +GT+ L D + + H++ V + FS + + Sbjct: 63 SHFVSDVVISS-DGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDN-RQI 120 Query: 272 ASLSEDCSLAVLDS--SLSELFRSQAHRDFVRDATWSPL-NHSLLTTVGWDHQVV 323 S S D ++ + ++ + ++H ++V +SP ++ ++ + GWD V Sbjct: 121 VSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVK 175 Score = 50.9 bits (120), Expect = 9e-07, Method: Composition-based stats. Identities = 34/186 (18%), Positives = 56/186 (30%), Gaps = 60/186 (32%) Query: 71 GFCSAGVQTEAG---VADLTWVGERG---ILVASDSGAVELWELDENETLIVSKFCKYEH 124 G C VQ E+ V+ + + I+ V++W L K H Sbjct: 136 GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNL----ANCKLKTNHIGH 191 Query: 125 DDIVSTVSVLSSGTQAVSGSKDI------------------------------------- 147 ++TV+V G+ SG KD Sbjct: 192 TGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAA 251 Query: 148 ---CIKVWDLAQQVVLSSY---------RAHAAQVTCVAASPHKDSVFLSCSEDNRILLW 195 IK+WDL ++++ +A Q T +A S ++F DN + +W Sbjct: 252 TGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFA-GYTDNLVRVW 310 Query: 196 DTRCPK 201 Sbjct: 311 QVTIGT 316 Score = 35.5 bits (80), Expect = 0.038, Method: Composition-based stats. Identities = 15/95 (15%), Positives = 34/95 (35%), Gaps = 5/95 (5%) Query: 69 NEGFCSAGVQTEAGVADLTWVGERGILVASDSGAVELWELDEN-----ETLIVSKFCKYE 123 NEG + + L + R L A+ ++++W+L+ V Sbjct: 222 NEGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKA 281 Query: 124 HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQV 158 ++++ + G +G D ++VW + Sbjct: 282 EPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGT 316 >6QDV-o nrPDB Length = 513 Score = 171 bits (432), Expect = 6e-43, Method: Composition-based stats. Identities = 60/319 (18%), Positives = 112/319 (35%), Gaps = 31/319 (9%) Query: 19 LPPNAPACMERQLEAARYRSDGALLLGASSLSGRCW-AGSLWLFKDPCAAPNEGFCSAG- 76 +PP ++Q+ + G + LSG + S+ E C Sbjct: 203 MPPEKCYLPKKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTF 262 Query: 77 VQTEAGVADLTW-VGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLS 135 + V D+ + L A+ ++LW+ + + ++ + + V Sbjct: 263 IGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQC-----ISRFTNRKVPYCVKFNP 317 Query: 136 S---GTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRI 192 V+G D I WD+ ++ Y H V + ++ F+S S+D + Sbjct: 318 DEDKQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFV-DENRRFVSTSDDKSL 376 Query: 193 LLWDTRCPKPASQIGCSAPGYLPTS--------LAWHPQQSEVFVFGDENGTVSLVDTKS 244 +W+ P I + +P LA +++ +FG +N L K Sbjct: 377 RVWEWDIPVDFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQN-RFRLNKKK- 434 Query: 245 TSCVLSSAVH--SQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELF-RSQAHRDFVR 301 H + + FSP + ++ S + L + D ++L+ R +AH Sbjct: 435 -----IFKGHMVAGYACQVDFSPD-MSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCI 488 Query: 302 DATWSPLNHSLLTTVGWDH 320 A W P S + T GWD Sbjct: 489 GAVWHPHETSKVITCGWDG 507 Score = 70.9 bits (172), Expect = 8e-13, Method: Composition-based stats. Identities = 29/159 (18%), Positives = 48/159 (30%), Gaps = 45/159 (28%) Query: 83 VADLTWVGE-RGILVASDSGAVELWELD-------------------------------- 109 V + +V E R + SD ++ +WE D Sbjct: 355 VNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHSMPAVTLSPNGKWLACQS 414 Query: 110 ----------ENETLIVSKFCKYEH--DDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQ 157 +N + K H V + +SG + + +WD Sbjct: 415 MDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTT 474 Query: 158 VVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWD 196 + S ++AH PH+ S ++C D I LWD Sbjct: 475 KLYSRFKAHDKVCIGAVWHPHETSKVITCGWDGLIKLWD 513 >5FVM-C nrPDB Length = 303 Score = 170 bits (431), Expect = 7e-43, Method: Composition-based stats. Identities = 66/271 (24%), Positives = 113/271 (41%), Gaps = 17/271 (6%) Query: 71 GFCSAGVQ-TEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVS 129 G CS +Q ++ V L ++ L A+ V L+++ N VS F H V+ Sbjct: 22 GVCSRTIQHADSQVNRLEITSDKKYLAAAGHLHVRLYDIRSNNPNPVSSF--EGHKGNVT 79 Query: 130 TVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSED 189 +++ VS S+D IKVWD+ V +Y+ H A V VA P++ +SC +D Sbjct: 80 SIAFQQENRWMVSSSEDGTIKVWDVRSPSVQRNYK-HNAPVNEVAIHPNQGE-LISCDQD 137 Query: 190 NRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLV------DTK 243 I +WD + +Q+ SL+ + V G+ G + D Sbjct: 138 GNIRIWDLGENQCTNQL-TPEDNTPLQSLSVAS-DGSMLVAGNNKGNCYVWRMPHHTDAS 195 Query: 244 STSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRS--QAHRDFVR 301 + V H++ +T ++ S V LA+ S D + V + + + H+ +V Sbjct: 196 TLEPVTKFKSHTKYITRVLLS-ADVKNLATCSADHTARVWNIEDNYQLETTLDGHQRWVW 254 Query: 302 DATWSPLNHSLLTTVGWDHQVVHHVVPTEPL 332 D +S + + L T DH V + T + Sbjct: 255 DCAFS-ADSAYLVTACSDHYVRLWDLSTSEI 284 Score = 93.3 bits (230), Expect = 2e-19, Method: Composition-based stats. Identities = 42/233 (18%), Positives = 70/233 (30%), Gaps = 56/233 (24%) Query: 140 AVSGSKDICIKVWDLAQQVV---------------------------------------- 159 S D I+ W+ V Sbjct: 5 LASAGYDHTIRFWEALTGVCSRTIQHADSQVNRLEITSDKKYLAAAGHLHVRLYDIRSNN 64 Query: 160 ---LSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPT 216 +SS+ H VT +A ++ +S SED I +WD R P +AP Sbjct: 65 PNPVSSFEGHKGNVTSIAF-QQENRWMVSSSEDGTIKVWDVRSPSVQRNYKHNAP---VN 120 Query: 217 SLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSE 276 +A HP Q E+ D++G + + D C + L + + Sbjct: 121 EVAIHPNQGELI-SCDQDGNIRIWDLGENQCTNQLTPEDNTPLQSLSVASDGSMLVAGNN 179 Query: 277 DCSLAVL------DSSLSE-LFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQV 322 + V D+S E + + ++H ++ S + L T DH Sbjct: 180 KGNCYVWRMPHHTDASTLEPVTKFKSHTKYITRVLLS-ADVKNLATCSADHTA 231 Score = 86.3 bits (212), Expect = 2e-17, Method: Composition-based stats. Identities = 29/143 (20%), Positives = 49/143 (34%), Gaps = 8/143 (5%) Query: 182 VFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVD 241 + S D+ I W+ + I + L + + G V L D Sbjct: 4 ILASAGYDHTIRFWEALTGVCSRTIQHA--DSQVNRLEITSDKKYLAAAGH--LHVRLYD 59 Query: 242 TK--STSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHRDF 299 + + + V S H VT + F ++ S SED ++ V D + R+ H Sbjct: 60 IRSNNPNPVSSFEGHKGNVTSIAFQ-QENRWMVSSSEDGTIKVWDVRSPSVQRNYKHNAP 118 Query: 300 VRDATWSPLNHSLLTTVGWDHQV 322 V + P N L + D + Sbjct: 119 VNEVAIHP-NQGELISCDQDGNI 140 Score = 73.6 bits (179), Expect = 1e-13, Method: Composition-based stats. Identities = 20/130 (15%), Positives = 48/130 (36%), Gaps = 4/130 (3%) Query: 92 RGILVASDSGAVELWEL--DENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICI 149 ++ ++ G +W + + + + H ++ V + + + S D Sbjct: 172 SMLVAGNNKGNCYVWRMPHHTDASTLEPVTKFKSHTKYITRVLLSADVKNLATCSADHTA 231 Query: 150 KVWDLA-QQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGC 208 +VW++ + ++ H V A S + ++ D+ + LWD + Q G Sbjct: 232 RVWNIEDNYQLETTLDGHQRWVWDCAFSAD-SAYLVTACSDHYVRLWDLSTSEIVRQYGG 290 Query: 209 SAPGYLPTSL 218 G + +L Sbjct: 291 HHKGAVCVAL 300 Score = 66.3 bits (160), Expect = 2e-11, Method: Composition-based stats. Identities = 25/147 (17%), Positives = 55/147 (37%), Gaps = 8/147 (5%) Query: 31 LEAARYRSDGALLLGASSLSGRCWAGSLWLFKDPCAAPNEGFCSAGVQTEAGVADLTWVG 90 L++ SDG++L+ ++ G C+ +W A + + + Sbjct: 162 LQSLSVASDGSMLVAGNN-KGNCY---VWRMPHHTDASTLEPVTKFKSHTKYITRVLLSA 217 Query: 91 E-RGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICI 149 + + + S +W +++N L + H V + + V+ D + Sbjct: 218 DVKNLATCSADHTARVWNIEDNYQL---ETTLDGHQRWVWDCAFSADSAYLVTACSDHYV 274 Query: 150 KVWDLAQQVVLSSYRAHAAQVTCVAAS 176 ++WDL+ ++ Y H CVA + Sbjct: 275 RLWDLSTSEIVRQYGGHHKGAVCVALN 301 >3C9C-A nrPDB Length = 432 Score = 170 bits (430), Expect = 9e-43, Method: Composition-based stats. Identities = 46/220 (20%), Positives = 90/220 (40%), Gaps = 21/220 (9%) Query: 124 HDDIVSTVSVLSSG-TQAVSGSKDICIKVWDLA--------QQVVLSSYR--AHAAQVTC 172 H+ V+ + + + + V+D R H + Sbjct: 129 HEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYG 188 Query: 173 VAASPHKDSVFLSCSEDNRILLWDTR-CPKPASQIGC----SAPGYLPTSLAWHPQQSEV 227 ++ +P+ + LS S+D+ I LWD PK I + + +AWH + Sbjct: 189 LSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESL 248 Query: 228 FVFGDENGTVSLVDTKSTS---CVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLD 284 F ++ + + DT++ + + H+ V L F+P+S LA+ S D ++A+ D Sbjct: 249 FGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 308 Query: 285 SSL--SELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQV 322 +L ++H+D + WSP N ++L + G D ++ Sbjct: 309 LRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRL 348 Score = 161 bits (407), Expect = 4e-40, Method: Composition-based stats. Identities = 46/231 (19%), Positives = 82/231 (35%), Gaps = 30/231 (12%) Query: 36 YRSDGALLLGASSLSGRCWAGS------LWLFKDPCAAPNEGFCSAGVQTEAG----VAD 85 ++ +G L +L+G + S LW D A P E G V D Sbjct: 182 HQKEGYGLSWNPNLNGYLLSASDDHTICLW---DINATPKEHRVIDAKNIFTGHTAVVED 238 Query: 86 LTW--VGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAV-S 142 + W + E +D + +W+ N T S H V+ +S + + Sbjct: 239 VAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVD-AHTAEVNCLSFNPYSEFILAT 297 Query: 143 GSKDICIKVWDLAQQVV-LSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDT---- 197 GS D + +WDL + L S+ +H ++ V SPH +++ S D R+ +WD Sbjct: 298 GSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIG 357 Query: 198 --------RCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLV 240 P + +W+P + + E+ + + Sbjct: 358 EEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVW 408 Score = 142 bits (359), Expect = 1e-34, Method: Composition-based stats. Identities = 49/229 (21%), Positives = 87/229 (37%), Gaps = 25/229 (10%) Query: 117 SKFCKYEHDDIVSTVSVLSS-GTQAVSGSKDICIKVWDLAQQVVLSS-------YRAHAA 168 H +S + +S S D I +WD+ + H A Sbjct: 175 PDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTA 234 Query: 169 QVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPAS-QIGCSAPGYLPTSLAWHPQQSEV 227 V VA +S+F S ++D ++++WDTR + A L+++P + Sbjct: 235 VVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFI 294 Query: 228 FVFGDENGTVSLVDTKSTSC-VLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLD-S 285 G + TV+L D ++ + S H + + +SPH+ LAS D L V D S Sbjct: 295 LATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLS 354 Query: 286 SLSELFRSQ--------------AHRDFVRDATWSPLNHSLLTTVGWDH 320 + E ++ H + D +W+P ++ +V D+ Sbjct: 355 KIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDN 403 Score = 60.5 bits (145), Expect = 1e-09, Method: Composition-based stats. Identities = 26/132 (19%), Positives = 46/132 (34%), Gaps = 18/132 (13%) Query: 210 APGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTK--------STSCV--LSSAVHSQCVT 259 + PQ + V + V + D S C L H + Sbjct: 128 NHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGY 187 Query: 260 GLVFSPHSVPFLASLSEDCSLAVLDSSLSELFR--------SQAHRDFVRDATWSPLNHS 311 GL ++P+ +L S S+D ++ + D + + H V D W L+ S Sbjct: 188 GLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHES 247 Query: 312 LLTTVGWDHQVV 323 L +V D +++ Sbjct: 248 LFGSVADDQKLM 259 Score = 42.0 bits (97), Expect = 3e-04, Method: Composition-based stats. Identities = 14/89 (15%), Positives = 29/89 (32%), Gaps = 11/89 (12%) Query: 254 HSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSL-----------SELFRSQAHRDFVRD 302 H V + P + +A+ + + V D + R + H+ Sbjct: 129 HEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYG 188 Query: 303 ATWSPLNHSLLTTVGWDHQVVHHVVPTEP 331 +W+P + L + DH + + P Sbjct: 189 LSWNPNLNGYLLSASDDHTICLWDINATP 217 >3CFV-B nrPDB Length = 414 Score = 169 bits (429), Expect = 1e-42, Method: Composition-based stats. Identities = 49/231 (21%), Positives = 84/231 (36%), Gaps = 30/231 (12%) Query: 36 YRSDGALLLGASSLSGRCWAGS------LWLFKDPCAAPNEGFCSAGVQTEAG----VAD 85 ++ +G L S+LSG + S LW D A P EG G V D Sbjct: 178 HQKEGYGLSWNSNLSGHLLSASDDHTVCLW---DINAGPKEGKIVDAKAIFTGHSAVVED 234 Query: 86 LTW--VGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAV-S 142 + W + E +D + +W+ N T S H V+ +S + + Sbjct: 235 VAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVD-AHTAEVNCLSFNPYSEFILAT 293 Query: 143 GSKDICIKVWDLAQQVV-LSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDT---- 197 GS D + +WDL + L ++ +H ++ V SPH +++ S D R+ +WD Sbjct: 294 GSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIG 353 Query: 198 --------RCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLV 240 P + +W+P + V E+ + + Sbjct: 354 EEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIW 404 Score = 165 bits (418), Expect = 2e-41, Method: Composition-based stats. Identities = 48/233 (20%), Positives = 92/233 (39%), Gaps = 25/233 (10%) Query: 113 TLIVSKFCKYEHDDIVSTVSVLSSGTQAV---SGSKDICIKVWDLA--------QQVVLS 161 T + K H+ V+ + + + S D + V+D Sbjct: 114 TGKIECEIKINHEGEVNRARYMPQNPHIIATKTPSSD--VLVFDYTKHPAKPDPSGECNP 171 Query: 162 SYR--AHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQI-----GCSAPGYL 214 R H + ++ + + LS S+D+ + LWD +I + + Sbjct: 172 DLRLRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAV 231 Query: 215 PTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSA---VHSQCVTGLVFSPHSVPFL 271 +AWH +F ++ + + DT+S + S H+ V L F+P+S L Sbjct: 232 VEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFIL 291 Query: 272 ASLSEDCSLAVLDSSL--SELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQV 322 A+ S D ++A+ D +L ++H+D + WSP N ++L + G D ++ Sbjct: 292 ATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRL 344 Score = 140 bits (353), Expect = 8e-34, Method: Composition-based stats. Identities = 54/281 (19%), Positives = 108/281 (38%), Gaps = 33/281 (11%) Query: 73 CSAGVQTEAGVADLTWVGERGILVASD--SGAVELWELDEN------ETLIVSKFCKYEH 124 C + E V ++ + ++A+ S V +++ ++ H Sbjct: 119 CEIKINHEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGH 178 Query: 125 DDIVSTVSVLSS-GTQAVSGSKDICIKVWDLAQQ-------VVLSSYRAHAAQVTCVAAS 176 +S S+ +S S D + +WD+ + + H+A V VA Sbjct: 179 QKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWH 238 Query: 177 PHKDSVFLSCSEDNRILLWDTRCPKPASQIGC-SAPGYLPTSLAWHPQQSEVFVFGDENG 235 +S+F S ++D ++++WDTR + A L+++P + G + Sbjct: 239 LLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADK 298 Query: 236 TVSLVDTKSTSC-VLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLD-SSLSELFRS 293 TV+L D ++ + + H + + +SPH+ LAS D L V D S + E + Sbjct: 299 TVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSA 358 Query: 294 Q--------------AHRDFVRDATWSPLNHSLLTTVGWDH 320 + H + D +W+P ++ +V D+ Sbjct: 359 EDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDN 399 Score = 56.3 bits (134), Expect = 2e-08, Method: Composition-based stats. Identities = 24/166 (14%), Positives = 51/166 (30%), Gaps = 43/166 (25%) Query: 166 HAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQS 225 H +V P + + + + +L++D HP + Sbjct: 125 HEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTK---------------------HPAKP 163 Query: 226 EVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDS 285 + + + + H + GL ++ + L S S+D ++ + D Sbjct: 164 DPSGECNPDLRLR--------------GHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDI 209 Query: 286 SLSELFR--------SQAHRDFVRDATWSPLNHSLLTTVGWDHQVV 323 + H V D W L+ SL +V D +++ Sbjct: 210 NAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESLFGSVADDQKLM 255 >5YZG-W nrPDB Length = 579 Score = 169 bits (428), Expect = 1e-42, Method: Composition-based stats. Identities = 60/319 (18%), Positives = 112/319 (35%), Gaps = 31/319 (9%) Query: 19 LPPNAPACMERQLEAARYRSDGALLLGASSLSGRCW-AGSLWLFKDPCAAPNEGFCSAG- 76 +PP ++Q+ + G + LSG + S+ E C Sbjct: 269 MPPEKCYLPKKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTF 328 Query: 77 VQTEAGVADLTW-VGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLS 135 + V D+ + L A+ ++LW+ + + ++ + + V Sbjct: 329 IGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQC-----ISRFTNRKVPYCVKFNP 383 Query: 136 S---GTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRI 192 V+G D I WD+ ++ Y H V + ++ F+S S+D + Sbjct: 384 DEDKQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFV-DENRRFVSTSDDKSL 442 Query: 193 LLWDTRCPKPASQIGCSAPGYLPTS--------LAWHPQQSEVFVFGDENGTVSLVDTKS 244 +W+ P I + +P LA +++ +FG +N L K Sbjct: 443 RVWEWDIPVDFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQN-RFRLNKKK- 500 Query: 245 TSCVLSSAVH--SQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELF-RSQAHRDFVR 301 H + + FSP + ++ S + L + D ++L+ R +AH Sbjct: 501 -----IFKGHMVAGYACQVDFSPD-MSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCI 554 Query: 302 DATWSPLNHSLLTTVGWDH 320 A W P S + T GWD Sbjct: 555 GAVWHPHETSKVITCGWDG 573 Score = 70.5 bits (171), Expect = 1e-12, Method: Composition-based stats. Identities = 29/159 (18%), Positives = 48/159 (30%), Gaps = 45/159 (28%) Query: 83 VADLTWVGE-RGILVASDSGAVELWELD-------------------------------- 109 V + +V E R + SD ++ +WE D Sbjct: 421 VNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHSMPAVTLSPNGKWLACQS 480 Query: 110 ----------ENETLIVSKFCKYEH--DDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQ 157 +N + K H V + +SG + + +WD Sbjct: 481 MDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTT 540 Query: 158 VVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWD 196 + S ++AH PH+ S ++C D I LWD Sbjct: 541 KLYSRFKAHDKVCIGAVWHPHETSKVITCGWDGLIKLWD 579 >5Y1U-A nrPDB Length = 456 Score = 169 bits (427), Expect = 2e-42, Method: Composition-based stats. Identities = 49/231 (21%), Positives = 84/231 (36%), Gaps = 30/231 (12%) Query: 36 YRSDGALLLGASSLSGRCWAGS------LWLFKDPCAAPNEGFCSAGVQTEAG----VAD 85 ++ +G L +LSG + S LW D A P EG G V D Sbjct: 207 HQKEGYGLSWNPNLSGHLLSASDDHTICLW---DISAVPKEGKVVDAKTIFTGHTAVVED 263 Query: 86 LTW--VGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAV-S 142 ++W + E +D + +W+ N T S H V+ +S + + Sbjct: 264 VSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVD-AHTAEVNCLSFNPYSEFILAT 322 Query: 143 GSKDICIKVWDLAQQVV-LSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDT---- 197 GS D + +WDL + L S+ +H ++ V SPH +++ S D R+ +WD Sbjct: 323 GSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIG 382 Query: 198 --------RCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLV 240 P + +W+P + V E+ + + Sbjct: 383 EEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW 433 Score = 166 bits (420), Expect = 1e-41, Method: Composition-based stats. Identities = 48/222 (21%), Positives = 91/222 (40%), Gaps = 25/222 (11%) Query: 124 HDDIVSTVSVLSSGTQAV---SGSKDICIKVWDLA--------QQVVLSSYR--AHAAQV 170 H+ V+ + + + S D + V+D R H + Sbjct: 154 HEGEVNRARYMPQNPCIIATKTPSSD--VLVFDYTKHPSKPDPSGECNPDLRLRGHQKEG 211 Query: 171 TCVAASPHKDSVFLSCSEDNRILLWDTRC-PKPASQIGC----SAPGYLPTSLAWHPQQS 225 ++ +P+ LS S+D+ I LWD PK + + + ++WH Sbjct: 212 YGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHE 271 Query: 226 EVFVFGDENGTVSLVDTKSTSCVLSSA---VHSQCVTGLVFSPHSVPFLASLSEDCSLAV 282 +F ++ + + DT+S + S H+ V L F+P+S LA+ S D ++A+ Sbjct: 272 SLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVAL 331 Query: 283 LDSSL--SELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQV 322 D +L ++H+D + WSP N ++L + G D ++ Sbjct: 332 WDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRL 373 Score = 141 bits (356), Expect = 3e-34, Method: Composition-based stats. Identities = 49/231 (21%), Positives = 89/231 (38%), Gaps = 25/231 (10%) Query: 115 IVSKFCKYEHDDIVSTVSVLSS-GTQAVSGSKDICIKVWDL----AQQVVLSS---YRAH 166 H +S + +S S D I +WD+ + V+ + + H Sbjct: 198 CNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGH 257 Query: 167 AAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPAS-QIGCSAPGYLPTSLAWHPQQS 225 A V V+ +S+F S ++D ++++WDTR + A L+++P Sbjct: 258 TAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSE 317 Query: 226 EVFVFGDENGTVSLVDTKSTSC-VLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLD 284 + G + TV+L D ++ + S H + + +SPH+ LAS D L V D Sbjct: 318 FILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWD 377 Query: 285 SSLSELFRSQ---------------AHRDFVRDATWSPLNHSLLTTVGWDH 320 S +S H + D +W+P ++ +V D+ Sbjct: 378 LSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDN 428 Score = 57.8 bits (138), Expect = 7e-09, Method: Composition-based stats. Identities = 26/179 (14%), Positives = 58/179 (32%), Gaps = 43/179 (24%) Query: 153 DLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPG 212 ++ ++ + H +V P + + + + +L++D Sbjct: 141 SVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTK------------- 187 Query: 213 YLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLA 272 HP + + + + + H + GL ++P+ L Sbjct: 188 --------HPSKPDPSGECNPDLRLR--------------GHQKEGYGLSWNPNLSGHLL 225 Query: 273 SLSEDCSLAVLDSSLSELFR--------SQAHRDFVRDATWSPLNHSLLTTVGWDHQVV 323 S S+D ++ + D S H V D +W L+ SL +V D +++ Sbjct: 226 SASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLM 284 >6QX9-5O nrPDB Length = 357 Score = 166 bits (421), Expect = 9e-42, Method: Composition-based stats. Identities = 50/199 (25%), Positives = 84/199 (42%), Gaps = 14/199 (7%) Query: 90 GERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICI 149 G + + SD G V+LW++ + + +++ V V+ + Q +SG D I Sbjct: 163 GPQLVCTGSDDGTVKLWDIRKKAAIQT-----FQNTYQVLAVTFNDTSDQIISGGIDNDI 217 Query: 150 KVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTR----CPKPASQ 205 KVWDL Q + + R HA VT ++ S + S LS + DN + +WD R + Sbjct: 218 KVWDLRQNKLTYTMRGHADSVTGLSLSS-EGSYLLSNAMDNTVRVWDVRPFAPKERCVKI 276 Query: 206 IGCSAPGYLPT--SLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVF 263 + + +W P S+ G + V + DT S + H+ + + F Sbjct: 277 FQGNVHNFEKNLLRCSWSPDGSK-IAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAF 335 Query: 264 SPHSVPFLASLSEDCSLAV 282 P P + S S D L + Sbjct: 336 HPD-EPIIISASSDKRLYM 353 Score = 150 bits (379), Expect = 8e-37, Method: Composition-based stats. Identities = 50/242 (20%), Positives = 96/242 (39%), Gaps = 21/242 (8%) Query: 92 RGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAV-SGSKDICIK 150 + AS V +W+ + E + K H V++ G Q V +GS D +K Sbjct: 122 SMLFSASTDKTVAVWDSETGERVKRLK----GHTSFVNSCYPARRGPQLVCTGSDDGTVK 177 Query: 151 VWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSA 210 +WD+ ++ + +++ QV V + D + +S DN I +WD R K + A Sbjct: 178 LWDIRKKAAIQTFQN-TYQVLAVTFNDTSDQI-ISGGIDNDIKVWDLRQNKLTYTMRGHA 235 Query: 211 PGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTK----STSCVLSSAV--HSQCVTGL--V 262 SL+ + + + TV + D + CV H+ L Sbjct: 236 DSVTGLSLS---SEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCS 292 Query: 263 FSPHSVPFLASLSEDCSLAVLDSSLSE-LFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQ 321 +SP +A+ S D + V D++ L++ H + + + P + ++ + D + Sbjct: 293 WSPDGSK-IAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHP-DEPIIISASSDKR 350 Query: 322 VV 323 + Sbjct: 351 LY 352 Score = 142 bits (357), Expect = 3e-34, Method: Composition-based stats. Identities = 43/243 (17%), Positives = 82/243 (33%), Gaps = 18/243 (7%) Query: 90 GERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICI 149 + A + LW + + + H V + + G+ S S D + Sbjct: 77 NGSTLASAGFDRLILLWNVYGDCDNYAT---LKGHSGAVMELHYNTDGSMLFSASTDKTV 133 Query: 150 KVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCS 209 VWD + + H + V + + + S+D + LWD R Sbjct: 134 AVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQ-- 191 Query: 210 APGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVP 269 Y ++ ++ S+ + G + + + D + + H+ VTGL S Sbjct: 192 -NTYQVLAVTFN-DTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSY 249 Query: 270 FLASLSEDCSLAVLDS-------SLSELFRSQAH--RDFVRDATWSPLNHSLLTTVGWDH 320 L S + D ++ V D ++F+ H + +WSP + S + D Sbjct: 250 LL-SNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSP-DGSKIAAGSADR 307 Query: 321 QVV 323 V Sbjct: 308 FVY 310 Score = 142 bits (357), Expect = 3e-34, Method: Composition-based stats. Identities = 41/212 (19%), Positives = 83/212 (39%), Gaps = 9/212 (4%) Query: 123 EHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQ-VVLSSYRAHAAQVTCVAASPHKDS 181 H+ V +G+ S D I +W++ ++ + H+ V + + S Sbjct: 64 GHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTD-GS 122 Query: 182 VFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVD 241 + S S D + +WD+ + ++ S + ++ G ++GTV L D Sbjct: 123 MLFSASTDKTVAVWDSETGERVKRLK--GHTSFVNSCYPARRGPQLVCTGSDDGTVKLWD 180 Query: 242 TKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSEL-FRSQAHRDFV 300 + + + + ++ V + F+ + + S D + V D ++L + + H D V Sbjct: 181 IRKKAAIQTFQ-NTYQVLAVTFN-DTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSV 238 Query: 301 RDATWSPLNHSLLTTVGWDHQV-VHHVVPTEP 331 + S S L + D+ V V V P P Sbjct: 239 TGLSLSS-EGSYLLSNAMDNTVRVWDVRPFAP 269 Score = 77.5 bits (189), Expect = 7e-15, Method: Composition-based stats. Identities = 24/116 (20%), Positives = 48/116 (41%), Gaps = 6/116 (5%) Query: 83 VADLTWVGE-RGILVASDSGAVELWELD----ENETLIVSKFCKYEHDDIVSTVSVLSSG 137 V L+ E +L + V +W++ + + + + + + + S G Sbjct: 238 VTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDG 297 Query: 138 TQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRIL 193 ++ +GS D + VWD + +L HA + VA P + + +S S D R+ Sbjct: 298 SKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEP-IIISASSDKRLY 352 Score = 52.8 bits (125), Expect = 2e-07, Method: Composition-based stats. Identities = 14/80 (17%), Positives = 29/80 (36%), Gaps = 4/80 (5%) Query: 245 TSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDS--SLSELFRSQAHRDFVRD 302 + ++ + H V F P+ LAS D + + + + H V + Sbjct: 56 QAPIMLLSGHEGEVYCCKFHPNGST-LASAGFDRLILLWNVYGDCDNYATLKGHSGAVME 114 Query: 303 ATWSPLNHSLLTTVGWDHQV 322 ++ + S+L + D V Sbjct: 115 LHYN-TDGSMLFSASTDKTV 133 >6EMK-B nrPDB Length = 303 Score = 166 bits (421), Expect = 1e-41, Method: Composition-based stats. Identities = 62/271 (22%), Positives = 104/271 (38%), Gaps = 17/271 (6%) Query: 71 GFCSAGVQ-TEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVS 129 G CS +Q +++ V L ++ +L + V L+++ V+ F H V+ Sbjct: 22 GVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRTTNPNPVASF--EGHRGNVT 79 Query: 130 TVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSED 189 +VS V+ S+D IKVWD+ + +Y+ H A V V P++ +SC D Sbjct: 80 SVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAPVNEVVIHPNQGE-LISCDRD 137 Query: 190 NRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLV------DTK 243 I +WD + Q+ SL+ + + G + D Sbjct: 138 GNIRIWDLGENQCTHQL-TPEDDTSLQSLSMAS-DGSMLAAANTKGNCYVWEMPNHTDAS 195 Query: 244 STSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVL--DSSLSELFRSQAHRDFVR 301 V HS +T ++ S V LA+ S D + V D H+ +V Sbjct: 196 HLKPVTKFRAHSTYITRILLS-SDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVW 254 Query: 302 DATWSPLNHSLLTTVGWDHQVVHHVVPTEPL 332 D +S + + L T DH V + T + Sbjct: 255 DCAFS-ADSAYLVTASSDHYVRLWDLSTREI 284 Score = 92.1 bits (227), Expect = 3e-19, Method: Composition-based stats. Identities = 33/191 (17%), Positives = 67/191 (35%), Gaps = 6/191 (3%) Query: 140 AVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRC 199 VS D I+ W+ V + + +QV + + + + + L+D R Sbjct: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEI-TNDKKLLATAGH-QNVRLYDIRT 62 Query: 200 PKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVT 259 P TS+++ Q + V E+GT+ + D +S S + H+ V Sbjct: 63 TNPNPVASFEGHRGNVTSVSFQ-QDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAPVN 120 Query: 260 GLVFSPHSVPFLASLSEDCSLAVLDSSLSEL-FRSQAHRDFVRDATWSPLNHSLLTTVGW 318 +V P+ + S D ++ + D ++ + D + + S+L Sbjct: 121 EVVIHPNQGELI-SCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANT 179 Query: 319 DHQVVHHVVPT 329 +P Sbjct: 180 KGNCYVWEMPN 190 Score = 83.3 bits (204), Expect = 2e-16, Method: Composition-based stats. Identities = 28/143 (19%), Positives = 50/143 (34%), Gaps = 8/143 (5%) Query: 182 VFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVD 241 + +S D+ I W+ + I S L ++ V L D Sbjct: 4 ILVSAGYDHTIRFWEALTGVCSRTIQHS--DSQVNRLEI-TNDKKLLATAGH-QNVRLYD 59 Query: 242 TK--STSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHRDF 299 + + + V S H VT + F + ++ + SED ++ V D + R+ H Sbjct: 60 IRTTNPNPVASFEGHRGNVTSVSFQQDN-RWMVTSSEDGTIKVWDVRSPSIPRNYKHNAP 118 Query: 300 VRDATWSPLNHSLLTTVGWDHQV 322 V + P N L + D + Sbjct: 119 VNEVVIHP-NQGELISCDRDGNI 140 Score = 75.2 bits (183), Expect = 4e-14, Method: Composition-based stats. Identities = 25/143 (17%), Positives = 55/143 (38%), Gaps = 5/143 (3%) Query: 80 EAGVADLTWVGERGILVASD-SGAVELWEL--DENETLIVSKFCKYEHDDIVSTVSVLSS 136 + + L+ + +L A++ G +WE+ + + + H ++ + + S Sbjct: 159 DTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSD 218 Query: 137 GTQAVSGSKDICIKVWDLAQQ-VVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLW 195 + S D +VW + + ++ H V A S + ++ S D+ + LW Sbjct: 219 VKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSAD-SAYLVTASSDHYVRLW 277 Query: 196 DTRCPKPASQIGCSAPGYLPTSL 218 D + Q G G + +L Sbjct: 278 DLSTREIVRQYGGHHKGAVCVAL 300 Score = 70.2 bits (170), Expect = 1e-12, Method: Composition-based stats. Identities = 26/150 (17%), Positives = 59/150 (39%), Gaps = 8/150 (5%) Query: 28 ERQLEAARYRSDGALLLGASSLSGRCWAGSLWLFKDPCAAPNEGFCSAGVQTEAGVADLT 87 + L++ SDG++L A++ G C+ +W + A + + + + Sbjct: 159 DTSLQSLSMASDGSML-AAANTKGNCY---VWEMPNHTDASHLKPVTKFRAHSTYITRIL 214 Query: 88 WVGE-RGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKD 146 + + + S +W +D++ + H V + + V+ S D Sbjct: 215 LSSDVKHLATCSADHTARVWSIDDD---FKLETTLDGHQRWVWDCAFSADSAYLVTASSD 271 Query: 147 ICIKVWDLAQQVVLSSYRAHAAQVTCVAAS 176 +++WDL+ + ++ Y H CVA + Sbjct: 272 HYVRLWDLSTREIVRQYGGHHKGAVCVALN 301 >6N9G-C nrPDB Length = 353 Score = 166 bits (419), Expect = 2e-41, Method: Composition-based stats. Identities = 50/219 (22%), Positives = 90/219 (41%), Gaps = 9/219 (4%) Query: 108 LDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHA 167 D+NE + K H + +S S +S Q ++ S D +WD+ +L S+ H Sbjct: 136 FDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHG 195 Query: 168 AQVTCVAASPHK-DSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSE 226 A V C+ +P + + F+S D + ++WD R + S+ ++P + Sbjct: 196 ADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQ--AFETHESDVNSVRYYP-SGD 252 Query: 227 VFVFGDENGTVSLVDTKSTSCVLSSAVHSQ--CVTGLVFSPHSVPFLASLSEDCSLAVLD 284 F G ++ T L D ++ V + S + + FS S L + D ++ V D Sbjct: 253 AFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFS-LSGRLLFAGYNDYTINVWD 311 Query: 285 -SSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQV 322 S + H + V SP + + + WDH + Sbjct: 312 VLKGSRVSILFGHENRVSTLRVSP-DGTAFCSGSWDHTL 349 Score = 131 bits (329), Expect = 4e-31, Method: Composition-based stats. Identities = 47/196 (23%), Positives = 77/196 (39%), Gaps = 9/196 (4%) Query: 90 GERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLS--SGTQAVSGSKDI 147 + IL AS G LW+++ + L H V + + +G VSG D Sbjct: 164 SDMQILTASGDGTCALWDVESGQLLQSFH----GHGADVLCLDLAPSETGNTFVSGGCDK 219 Query: 148 CIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIG 207 VWD+ + ++ H + V V P D+ F S S+D L+D R + + Sbjct: 220 KAMVWDMRSGQCVQAFETHESDVNSVRYYPSGDA-FASGSDDATCRLYDLRADREVAIYS 278 Query: 208 CSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHS 267 + + +S+ + + G + T+++ D S V H V+ L SP Sbjct: 279 KESIIFGASSVDF-SLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDG 337 Query: 268 VPFLASLSEDCSLAVL 283 F S S D +L V Sbjct: 338 TAF-CSGSWDHTLRVW 352 Score = 87.5 bits (215), Expect = 7e-18, Method: Composition-based stats. Identities = 30/219 (13%), Positives = 60/219 (27%), Gaps = 53/219 (24%) Query: 158 VVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTS 217 + + H +V C+ K + +S S+D ++++WD + + P + Sbjct: 54 KTRRTLKGHGNKVLCMDWCKDKRRI-VSSSQDGKVIVWD--SFTTNKEHAVTMPCTWVMA 110 Query: 218 LAWHPQQSEV-----------------------------------------------FVF 230 A+ P + + Sbjct: 111 CAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILT 170 Query: 231 GDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHS-VPFLASLSEDCSLAVLDSSLSE 289 +GT +L D +S + S H V L +P S D V D + Sbjct: 171 ASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQ 230 Query: 290 LFR-SQAHRDFVRDATWSPLNHSLLTTVGWDHQVVHHVV 327 + + H V + P + + D + + Sbjct: 231 CVQAFETHESDVNSVRYYP-SGDAFASGSDDATCRLYDL 268 Score = 55.9 bits (133), Expect = 3e-08, Method: Composition-based stats. Identities = 24/126 (19%), Positives = 48/126 (38%), Gaps = 13/126 (10%) Query: 28 ERQLEAARYRSDG-ALLLGASSLSGRCWAGSLWLFKDPCAAPNEGFCSAGVQTEAGVADL 86 E + + RY G A G+ + R + L ++ E + Sbjct: 239 ESDVNSVRYYPSGDAFASGSDDATCRLY--DLRADREVAIYSKESIIFGASSVDFS---- 292 Query: 87 TWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKD 146 + R + + + +W++ + + + + H++ VST+ V GT SGS D Sbjct: 293 --LSGRLLFAGYNDYTINVWDVLKGSRVSI----LFGHENRVSTLRVSPDGTAFCSGSWD 346 Query: 147 ICIKVW 152 ++VW Sbjct: 347 HTLRVW 352 >4YCZ-A nrPDB Length = 876 Score = 163 bits (412), Expect = 1e-40, Method: Composition-based stats. Identities = 45/247 (18%), Positives = 89/247 (36%), Gaps = 30/247 (12%) Query: 116 VSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLA--QQVVLSSYRAHAAQVTCV 173 HDD++ + G + + S D IK++++ Q + + + H V CV Sbjct: 9 TQVIANSGHDDMIHDAVLDYYGRRLATCSSDRTIKIFEIEGETQRLTETLKGHDGAVWCV 68 Query: 174 AA-SPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSE-VFVFG 231 + P ++ S D ++L+W + ++W P ++ + Sbjct: 69 SWAHPKYGNILASAGYDGKVLIWRELNGAWQRIFDFALHKASVNVVSWSPHEAGCLLACA 128 Query: 232 DENGTVSLVDTKSTS-CVLSSAVHSQCVTGLVFSPHSVP----------------FLASL 274 +G VS+++ + S H V + ++P + P + Sbjct: 129 SSDGNVSVLEFRDNSWEHSIFHAHGLGVNSVSWAPATSPGSIVSSKPGPKSTGNRRFVTG 188 Query: 275 SEDCSLAVLDSS-LSELFRSQ-----AHRDFVRDATWSP--LNHSLLTTVGWDHQV-VHH 325 D +L + + ++ + H D+VRD WSP L S + + D V + Sbjct: 189 GSDNALKIWAYDPATNTYKLEREPLTGHTDWVRDVAWSPTVLQKSYIASASEDRTVRIWT 248 Query: 326 VVPTEPL 332 P PL Sbjct: 249 SDPANPL 255 Score = 89.4 bits (220), Expect = 2e-18, Method: Composition-based stats. Identities = 38/233 (16%), Positives = 71/233 (30%), Gaps = 33/233 (14%) Query: 86 LTWVGERG---ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLS--SGTQA 140 ++W + + A G V +W + F H V+ VS +G Sbjct: 68 VSWAHPKYGNILASAGYDGKVLIWRELNGAWQRIFDFAL--HKASVNVVSWSPHEAGCLL 125 Query: 141 VSGSKDICIKVWDLA-QQVVLSSYRAHAAQVTCVAASPH----------------KDSVF 183 S D + V + S + AH V V+ +P + F Sbjct: 126 ACASSDGNVSVLEFRDNSWEHSIFHAHGLGVNSVSWAPATSPGSIVSSKPGPKSTGNRRF 185 Query: 184 LSCSEDNRILLWDTRCPKPASQIG---CSAPGYLPTSLAWHP--QQSEVFVFGDENGTVS 238 ++ DN + +W ++ + +AW P Q E+ TV Sbjct: 186 VTGGSDNALKIWAYDPATNTYKLEREPLTGHTDWVRDVAWSPTVLQKSYIASASEDRTVR 245 Query: 239 LVDTKSTSCVL---SSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLS 288 + + + + V + +S S LA+ D + + +L Sbjct: 246 IWTSDPANPLQWNCKVLNFDAAVWRVSWS-LSGNVLAASGGDNKVTLWKENLK 297 Score = 70.5 bits (171), Expect = 1e-12, Method: Composition-based stats. Identities = 24/126 (19%), Positives = 43/126 (34%), Gaps = 8/126 (6%) Query: 89 VGERGILVASDSGAVELWELD-ENETLIVSKFCKYEHDDIVSTVSVLSS---GTQAVSGS 144 G R + A+++W D T + + H D V V+ + + S S Sbjct: 180 TGNRRFVTGGSDNALKIWAYDPATNTYKLEREPLTGHTDWVRDVAWSPTVLQKSYIASAS 239 Query: 145 KDICIKVWDLAQQVVLS---SYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPK 201 +D +++W L A V V+ S + + S DN++ LW Sbjct: 240 EDRTVRIWTSDPANPLQWNCKVLNFDAAVWRVSWSLSGNVLAASGG-DNKVTLWKENLKG 298 Query: 202 PASQIG 207 + Sbjct: 299 EWECVK 304 >5OPT-p nrPDB Length = 318 Score = 162 bits (411), Expect = 2e-40, Method: Composition-based stats. Identities = 45/219 (20%), Positives = 83/219 (37%), Gaps = 9/219 (4%) Query: 95 LVASDSGAVELW----ELDENETLIVSKFCK-YEHDDIVSTVSVLSSGTQAVSGSKDICI 149 + S + W + + E + H VS V++ ++G AVS S D + Sbjct: 32 VSTSRDNTLIAWGSNMDRNSEECEYGFPERRLEGHSAFVSDVALSNNGDFAVSASWDHSL 91 Query: 150 KVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCS 209 ++W+L V + H V V SP + +S DN + +W+ + +G Sbjct: 92 RLWNLQTGVCQHKFLGHTKDVLSVTFSPDNRQI-VSGGRDNALRVWNV-KGECLHTLGRG 149 Query: 210 APGYLPTSLAWHP-QQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSV 268 A + + + P ++ + V G + V + D S + H+ +T + SP Sbjct: 150 AHTDWVSCVRFSPSLETPLIVSGGWDNLVKVWDIASGRLLTDLKGHTNYITSVTVSPDG- 208 Query: 269 PFLASLSEDCSLAVLDSSLSELFRSQAHRDFVRDATWSP 307 AS +D + D + E A + +SP Sbjct: 209 SLCASSDKDGVARLWDLTKGEALSEMAAGAPINQICFSP 247 Score = 127 bits (320), Expect = 5e-30, Method: Composition-based stats. Identities = 62/317 (19%), Positives = 102/317 (32%), Gaps = 59/317 (18%) Query: 15 REWNLPPNAPACMERQLEAARYRSDGALLLGASS----------------LSGR------ 52 R W P E ++A D L+ S+ L G Sbjct: 13 RGWVTALACPQITETYIKAVSTSRDNTLIAWGSNMDRNSEECEYGFPERRLEGHSAFVSD 72 Query: 53 -------------CWAGSLWLFKDPCAAPNEGFCSAGVQTEAGVADLTWVGE-RGILVAS 98 W SL L+ F V +T+ + R I+ Sbjct: 73 VALSNNGDFAVSASWDHSLRLWNLQTGVCQHKFLGHTKD----VLSVTFSPDNRQIVSGG 128 Query: 99 DSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLS--SGTQAVSGSKDICIKVWDLAQ 156 A+ +W + + E L + H D VS V VSG D +KVWD+A Sbjct: 129 RDNALRVWNV-KGECL--HTLGRGAHTDWVSCVRFSPSLETPLIVSGGWDNLVKVWDIAS 185 Query: 157 QVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPT 216 +L+ + H +T V SP S+ S +D LWD + S++ AP Sbjct: 186 GRLLTDLKGHTNYITSVTVSPD-GSLCASSDKDGVARLWDLTKGEALSEMAAGAP---IN 241 Query: 217 SLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQ-------CVTGLVFSPHSVP 269 + + P + ++ + + D ++ ++ A +Q + +S Sbjct: 242 QICFSP--NRYWMCAATEKGIRIFDLENKDVIVELAPEAQQKSKKTPECMSIAWSADGNT 299 Query: 270 FLASLSEDCSLAVLDSS 286 L S D + V S Sbjct: 300 -LYSGYTDNVIRVWSVS 315 Score = 103 bits (257), Expect = 9e-23, Method: Composition-based stats. Identities = 35/173 (20%), Positives = 66/173 (38%), Gaps = 12/173 (6%) Query: 162 SYRAHAAQVTCVAASPHKDSVF--LSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLA 219 + H VT +A ++ +S S DN ++ W + + + + P + Sbjct: 8 QLKGHRGWVTALACPQITETYIKAVSTSRDNTLIAWGSNMDRNSEECEYGFPERRLEGHS 67 Query: 220 WH------PQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLAS 273 + V + ++ L + ++ C H++ V + FSP + + S Sbjct: 68 AFVSDVALSNNGDFAVSASWDHSLRLWNLQTGVCQHKFLGHTKDVLSVTFSPDN-RQIVS 126 Query: 274 LSEDCSLAVLDSSLSELFRSQ--AHRDFVRDATWSP-LNHSLLTTVGWDHQVV 323 D +L V + L AH D+V +SP L L+ + GWD+ V Sbjct: 127 GGRDNALRVWNVKGECLHTLGRGAHTDWVSCVRFSPSLETPLIVSGGWDNLVK 179 Score = 43.2 bits (100), Expect = 1e-04, Method: Composition-based stats. Identities = 21/92 (22%), Positives = 30/92 (32%), Gaps = 13/92 (14%) Query: 250 SSAVHSQCVTGLVFSPHSVPFL--ASLSEDCSLAVL----DSSLSELF------RSQAHR 297 H VT L + ++ S S D +L D + E R + H Sbjct: 8 QLKGHRGWVTALACPQITETYIKAVSTSRDNTLIAWGSNMDRNSEECEYGFPERRLEGHS 67 Query: 298 DFVRDATWSPLNHSLLTTVGWDHQVVHHVVPT 329 FV D S N + WDH + + T Sbjct: 68 AFVSDVALS-NNGDFAVSASWDHSLRLWNLQT 98 >3BG0-A nrPDB Length = 316 Score = 162 bits (409), Expect = 2e-40, Method: Composition-based stats. Identities = 48/238 (20%), Positives = 87/238 (36%), Gaps = 30/238 (12%) Query: 116 VSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQ--VVLSSYRAHAAQVTCV 173 V H+D++ + GT+ + S D +K++D+ ++++ R H V V Sbjct: 4 VINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQV 63 Query: 174 AA-SPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEV-FVFG 231 A P ++ SCS D ++++W + S+ W P + G Sbjct: 64 AWAHPMYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACG 123 Query: 232 DENGTVSLVDTKSTSCVLSSA---VHSQCVTGLVFSPHSVP----------------FLA 272 +G +SL+ H+ + ++P VP A Sbjct: 124 SSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFA 183 Query: 273 SLSEDCSLAVL----DSSLSELFRSQAHRDFVRDATWSP---LNHSLLTTVGWDHQVV 323 S D + + D E + +AH D+VRD W+P L S + + D +V Sbjct: 184 SGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVF 241 Score = 74.8 bits (182), Expect = 5e-14, Method: Composition-based stats. Identities = 41/236 (17%), Positives = 70/236 (29%), Gaps = 35/236 (14%) Query: 80 EAGVADLTWVGE---RGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSV--L 134 E V + W + S V +W + + HD V++V Sbjct: 57 EGPVWQVAWAHPMYGNILASCSYDRKVIIWREENGTWEKSHEHA--GHDSSVNSVCWAPH 114 Query: 135 SSGTQAVSGSKDICIKV--WDLAQQVVLSSY-RAHAAQVTCVAAS--------------- 176 G GS D I + + Q + AH V+ + Sbjct: 115 DYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQ 174 Query: 177 -PHKDSVFLSCSEDNRILLW-DTRCPKPASQIGCSAPGYLPTSLAWHP---QQSEVFVFG 231 P+ F S DN I LW + + + A +AW P + Sbjct: 175 KPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASC 234 Query: 232 DENGTVSLV--DTKSTSCVLSSAVHS--QCVTGLVFSPHSVPFLASLSEDCSLAVL 283 ++G V + D S++ +H V + +S + LA D + + Sbjct: 235 SQDGRVFIWTCDDASSNTWSPKLLHKFNDVVWHVSWS-ITANILAVSGGDNKVTLW 289 >4BTS-AR nrPDB Length = 343 Score = 161 bits (408), Expect = 3e-40, Method: Composition-based stats. Identities = 47/250 (18%), Positives = 90/250 (36%), Gaps = 18/250 (7%) Query: 94 ILVASDSGAVELWEL---DENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIK 150 ++ S V +W+L ++N + H+ VS +++ A+S S D ++ Sbjct: 42 LISGSRDKTVMIWKLYEEEQNGYFGIPHKALTGHNHFVSDLALSQENCFAISSSWDKTLR 101 Query: 151 VWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSA 210 +WDL + H ++V VA SP + S + I LW+ S Sbjct: 102 LWDLRTGTTYKRFVGHQSEVYSVAFSPDNRQIL-SAGAEREIKLWNILGECKFSSAEKEN 160 Query: 211 PGYLPTSLAWHPQQS---------EVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGL 261 + + + P F +G + + +T + + H V L Sbjct: 161 HSDWVSCVRYSPIMKSANKVQPFAPYFASVGWDGRLKVWNT-NFQIRYTFKAHESNVNHL 219 Query: 262 VFSPHSVPFLASLSEDCSLAVLD-SSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDH 320 SP+ ++A+ +D L + D +L+ R + ++P VG D Sbjct: 220 SISPNG-KYIATGGKDKKLLIWDILNLTYPQREFDAGSTINQIAFNPKLQ--WVAVGTDQ 276 Query: 321 QVVHHVVPTE 330 V + T+ Sbjct: 277 GVKIFNLMTQ 286 Score = 123 bits (308), Expect = 1e-28, Method: Composition-based stats. Identities = 51/242 (21%), Positives = 92/242 (38%), Gaps = 31/242 (12%) Query: 107 ELDENETLIVSKFCKYEHDDIVSTVS--VLS----SGTQAVSGSKDICIKVWDL------ 154 + + +V + H D V+++ +SGS+D + +W L Sbjct: 3 DNSSLDIQVVKRGILEGHSDWVTSIVAGFSQKENEDSPVLISGSRDKTVMIWKLYEEEQN 62 Query: 155 -AQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGY 213 + + H V+ +A S ++ +S S D + LWD R + Sbjct: 63 GYFGIPHKALTGHNHFVSDLALS-QENCFAISSSWDKTLRLWDLRTGTTYKRFV--GHQS 119 Query: 214 LPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAV---HSQCVTGLVFSPHSV-- 268 S+A+ P ++ G E + L + C SSA HS V+ + +SP Sbjct: 120 EVYSVAFSPDNRQILSAGAE-REIKLWNIL-GECKFSSAEKENHSDWVSCVRYSPIMKSA 177 Query: 269 -------PFLASLSEDCSLAVLDSSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQ 321 P+ AS+ D L V +++ + +AH V + SP N + T G D + Sbjct: 178 NKVQPFAPYFASVGWDGRLKVWNTNFQIRYTFKAHESNVNHLSISP-NGKYIATGGKDKK 236 Query: 322 VV 323 ++ Sbjct: 237 LL 238 >3JRP-A nrPDB Length = 379 Score = 161 bits (407), Expect = 4e-40, Method: Composition-based stats. Identities = 45/236 (19%), Positives = 86/236 (36%), Gaps = 25/236 (10%) Query: 123 EHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLA--QQVVLSSYRAHAAQVTCVAA-SPHK 179 H++++ + G + + S D IK++++ ++ + H V V P Sbjct: 9 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKF 68 Query: 180 DSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQ-SEVFVFGDENGTVS 238 ++ SCS D ++L+W + + + S+ W P + + + +G VS Sbjct: 69 GTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVS 128 Query: 239 LVDTKSTSCVLS--SAVHSQCVTGLVFSPH------------SVPFLASLSEDCSLAVL- 283 +V+ K H+ V ++P + D + + Sbjct: 129 VVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWK 188 Query: 284 ---DSSLSELFRS-QAHRDFVRDATWSP--LNHSLLTTVGWDHQVVHHVVPTEPLP 333 D+ L + + H D+VRD WSP L S L +V D + E P Sbjct: 189 YNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGP 244 Score = 60.9 bits (146), Expect = 7e-10, Method: Composition-based stats. Identities = 21/115 (18%), Positives = 40/115 (34%), Gaps = 9/115 (7%) Query: 92 RGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSS---GTQAVSGSKDIC 148 R + V++W+ + + V + H D V V+ + + S S+D Sbjct: 173 RKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRT 232 Query: 149 IKVW--DLAQQVVLSSYRAHA---AQVTCVAASPHKDSVFLSCSEDNRILLWDTR 198 +W D Q + + + S + + LS DN++ LW Sbjct: 233 CIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGG-DNKVTLWKEN 286 >4V8M-A7 nrPDB Length = 318 Score = 161 bits (407), Expect = 4e-40, Method: Composition-based stats. Identities = 46/221 (20%), Positives = 81/221 (36%), Gaps = 9/221 (4%) Query: 93 GILVASDSGAVELW----ELDENETLIVSK-FCKYEHDDIVSTVSVLSSGTQAVSGSKDI 147 ++ S + W + +E H VS V++ ++G AVS S D Sbjct: 30 KVVSTSRDKTLLSWGPNPDRHSSECSYGLPDRRLEGHSAFVSDVALSNNGNFAVSASWDH 89 Query: 148 CIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIG 207 +++W+L + H V VA SP + +S DN + +W+ + + Sbjct: 90 SLRLWNLQNGQCQYKFLGHTKDVLSVAFSPDNRQI-VSGGRDNALRVWNV-KGECMHTLS 147 Query: 208 CSAPGYLPTSLAWHP-QQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPH 266 A + + + P + V V G + V + D + V H+ VT + SP Sbjct: 148 RGAHTDWVSCVRFSPSLDAPVIVSGGWDNLVKVWDLATGRLVTDLKGHTNYVTSVTVSPD 207 Query: 267 SVPFLASLSEDCSLAVLDSSLSELFRSQAHRDFVRDATWSP 307 AS +D + D + E A + +SP Sbjct: 208 G-SLCASSDKDGVARLWDLTKGEALSEMAAGAPINQICFSP 247 Score = 127 bits (319), Expect = 7e-30, Method: Composition-based stats. Identities = 59/318 (18%), Positives = 104/318 (32%), Gaps = 35/318 (11%) Query: 15 REWNLPPNAPACMERQLEAARYRSDGALLLGASSLSGRCWAGSLWLFKDPCAAPNEGFCS 74 R W P E + D LL + S P+ Sbjct: 13 RGWVTSLACPQTPETATKVVSTSRDKTLLSWGPNPDRHSSECSY-------GLPDR---- 61 Query: 75 AGVQTEAGVADLTWVGERGI-LVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSV 133 A V+D+ + AS ++ LW L + ++ H V +V+ Sbjct: 62 RLEGHSAFVSDVALSNNGNFAVSASWDHSLRLWNLQNGQC----QYKFLGHTKDVLSVAF 117 Query: 134 LSSGTQAVSGSKDICIKVWDLAQQVVLSSYR--AHAAQVTCVAASPHKDS-VFLSCSEDN 190 Q VSG +D ++VW++ + + AH V+CV SP D+ V +S DN Sbjct: 118 SPDNRQIVSGGRDNALRVWNVK-GECMHTLSRGAHTDWVSCVRFSPSLDAPVIVSGGWDN 176 Query: 191 RILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLS 250 + +WD + + TS+ P + D++G L D + Sbjct: 177 LVKVWDLATGRLVT--DLKGHTNYVTSVTVSP-DGSLCASSDKDGVARLWDLTKGEALSE 233 Query: 251 SAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHRD--------FVRD 302 A + + FSP+ + + + + + D ++ A Sbjct: 234 MAA-GAPINQICFSPN--RYWMCAATEKGIRIFDLENKDIIVELAPEHQGSKKIVPECVS 290 Query: 303 ATWSPLNHSLLTTVGWDH 320 WS + S L + D+ Sbjct: 291 IAWS-ADGSTLYSGYTDN 307 Score = 100 bits (250), Expect = 7e-22, Method: Composition-based stats. Identities = 36/179 (20%), Positives = 67/179 (37%), Gaps = 12/179 (6%) Query: 162 SYRAHAAQVTCVAA--SPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLA 219 H VT +A +P + +S S D +L W + +S+ P + Sbjct: 8 QLTGHRGWVTSLACPQTPETATKVVSTSRDKTLLSWGPNPDRHSSECSYGLPDRRLEGHS 67 Query: 220 WH------PQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLAS 273 V + ++ L + ++ C H++ V + FSP + + S Sbjct: 68 AFVSDVALSNNGNFAVSASWDHSLRLWNLQNGQCQYKFLGHTKDVLSVAFSPDN-RQIVS 126 Query: 274 LSEDCSLAVLDSSLSELFRSQ--AHRDFVRDATWSP-LNHSLLTTVGWDHQVVHHVVPT 329 D +L V + + AH D+V +SP L+ ++ + GWD+ V + T Sbjct: 127 GGRDNALRVWNVKGECMHTLSRGAHTDWVSCVRFSPSLDAPVIVSGGWDNLVKVWDLAT 185 Score = 55.1 bits (131), Expect = 4e-08, Method: Composition-based stats. Identities = 27/149 (18%), Positives = 44/149 (29%), Gaps = 52/149 (34%) Query: 94 ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWD 153 I+ V++W+L + H + V++V+V G+ S KD ++WD Sbjct: 169 IVSGGWDNLVKVWDLATGRLV----TDLKGHTNYVTSVTVSPDGSLCASSDKDGVARLWD 224 Query: 154 LAQQVVLSSYRAHAAQVTCVAASPH----------------------------------- 178 L + LS A A + + SP+ Sbjct: 225 LTKGEALSEMAA-GAPINQICFSPNRYWMCAATEKGIRIFDLENKDIIVELAPEHQGSKK 283 Query: 179 ------------KDSVFLSCSEDNRILLW 195 S S DN I +W Sbjct: 284 IVPECVSIAWSADGSTLYSGYTDNVIRVW 312 Score = 35.5 bits (80), Expect = 0.037, Method: Composition-based stats. Identities = 18/105 (17%), Positives = 40/105 (38%), Gaps = 8/105 (7%) Query: 56 GSLWLFKDPCAAPN-----EGFCSAGVQTEAGVADLTWVGERGILVASDSGAVELWELDE 110 GSL D +G + + A + + + R + A+ + +++L+ Sbjct: 208 GSLCASSDKDGVARLWDLTKGEALSEMAAGAPINQICFSPNRYWMCAATEKGIRIFDLEN 267 Query: 111 NETLIVSKFCKYEHDDIV---STVSVLSSGTQAVSGSKDICIKVW 152 + ++ IV +++ + G+ SG D I+VW Sbjct: 268 KDIIVELAPEHQGSKKIVPECVSIAWSADGSTLYSGYTDNVIRVW 312 >4BZK-B nrPDB Length = 297 Score = 156 bits (395), Expect = 1e-38, Method: Composition-based stats. Identities = 45/236 (19%), Positives = 86/236 (36%), Gaps = 25/236 (10%) Query: 123 EHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLA--QQVVLSSYRAHAAQVTCVAA-SPHK 179 H++++ + G + + S D IK++++ ++ + H V V P Sbjct: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKF 66 Query: 180 DSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQ-SEVFVFGDENGTVS 238 ++ SCS D ++L+W + + + S+ W P + + + +G VS Sbjct: 67 GTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVS 126 Query: 239 LVDTKSTSCVLS--SAVHSQCVTGLVFSPH------------SVPFLASLSEDCSLAVL- 283 +V+ K H+ V ++P + D + + Sbjct: 127 VVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWK 186 Query: 284 ---DSSLSELFRS-QAHRDFVRDATWSP--LNHSLLTTVGWDHQVVHHVVPTEPLP 333 D+ L + + H D+VRD WSP L S L +V D + E P Sbjct: 187 YNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGP 242 Score = 83.3 bits (204), Expect = 1e-16, Method: Composition-based stats. Identities = 41/186 (22%), Positives = 66/186 (35%), Gaps = 28/186 (15%) Query: 81 AGVADLTWVGER---GILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLS-- 135 A V + W +LVAS G V + E EN T S H V++ S Sbjct: 100 ASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGT--TSPIIIDAHAIGVNSASWAPAT 157 Query: 136 -----------SGTQAVSGSKDICIKVW----DLAQQVVLSSYRAHAAQVTCVAASPH-- 178 + V+G D +K+W D V+ S+ H+ V VA SP Sbjct: 158 IEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVL 217 Query: 179 KDSVFLSCSEDNRILLWDTRCPK-PASQIGCSAPGY--LPTSLAWHPQQSEVFVFGDENG 235 S S S+D ++W + P + + + +W + + + G + Sbjct: 218 LRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGG-DN 276 Query: 236 TVSLVD 241 V+L Sbjct: 277 KVTLWK 282 Score = 59.0 bits (141), Expect = 3e-09, Method: Composition-based stats. Identities = 21/115 (18%), Positives = 40/115 (34%), Gaps = 9/115 (7%) Query: 92 RGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSS---GTQAVSGSKDIC 148 R + V++W+ + + V + H D V V+ + + S S+D Sbjct: 171 RKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRT 230 Query: 149 IKVW--DLAQQVVLSSYRAHA---AQVTCVAASPHKDSVFLSCSEDNRILLWDTR 198 +W D Q + + + S + + LS DN++ LW Sbjct: 231 CIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGG-DNKVTLWKEN 284 >5XYI-g nrPDB Length = 335 Score = 156 bits (393), Expect = 2e-38, Method: Composition-based stats. Identities = 45/210 (21%), Positives = 87/210 (41%), Gaps = 13/210 (6%) Query: 81 AGVADLTWVGERGILV-ASDSGAVELWELDENETLIVSKFCKY-EHDDIVSTVSVLSSGT 138 A + + E LV AS + +W+L+ + + F + H+ VS VS+ + Sbjct: 34 AAIESIEIDNEHNYLVSASRDKSALVWKLNRTQEQWATPFTRLIGHNHFVSDVSLSRDAS 93 Query: 139 QAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTR 198 ++ S D +++WDL+ + + H V V SP + +S DN++ +W+ Sbjct: 94 HLLTSSWDSTLRLWDLSTRTTKKLFLGHKKDVLGVTFSPCNRRI-ISVGRDNQVKIWNI- 151 Query: 199 CPKPASQIGCSAPGYLPTSLAWHPQQSE----VFVFGDENGTVSLVDT-KSTSCVLSSAV 253 + +++ CS+ TS+A P E V G +G V + K + Sbjct: 152 LGENKAELQCSS---WVTSVACAPMADETSPLVIAVGCWDGKVYIWSIEKEAKLIKEFKA 208 Query: 254 HSQCVTGLVFSPHSVPFLASLSEDCSLAVL 283 H T + F+P ++ + D + + Sbjct: 209 HDGRCTSVDFTPDG-KWVITGGSDRKVVMW 237 Score = 84.0 bits (206), Expect = 8e-17, Method: Composition-based stats. Identities = 27/214 (12%), Positives = 69/214 (32%), Gaps = 30/214 (14%) Query: 91 ERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGT-----QAVSGSK 145 R I+ V++W + + + V++V+ G Sbjct: 134 NRRIISVGRDNQVKIWNILGEN------KAELQCSSWVTSVACAPMADETSPLVIAVGCW 187 Query: 146 DICIKVWDLAQQ-VVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPAS 204 D + +W + ++ ++ ++AH + T V +P ++ D ++++W T Sbjct: 188 DGKVYIWSIEKEAKLIKEFKAHDGRCTSVDFTPD-GKWVITGGSDRKVVMWLTENGAKTI 246 Query: 205 QIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDT---KSTSCVLSSAVHSQC---- 257 +P + + ++ ++ +++ D + V + H Sbjct: 247 SFTAPSPVHAVAACP-----TQAWICAATYEGIAVWDIGAKQQIDLVQPNFKHEGKRNAG 301 Query: 258 ----VTGLVFSPHSVPFLASLSEDCSLAVLDSSL 287 T L ++ L S D S+ + Sbjct: 302 RTPDCTCLAWAADG-SVLYSGYNDGSIRAWEVKS 334 >5L9T-R nrPDB Length = 493 Score = 155 bits (392), Expect = 2e-38, Method: Composition-based stats. Identities = 57/284 (20%), Positives = 98/284 (34%), Gaps = 11/284 (3%) Query: 41 ALLLGASSLSGRCWAGSLWLFKDPCAAPNEGFCSAGVQTEAGVADLTWVGERGILVASDS 100 L S+ S + + P + + +Q + + + W +L Sbjct: 148 YSLSPVSNKSQKLLRSPRKPTRKISKIPFKVLDAPELQDDFYLNLVDWSS-LNVLSVGLG 206 Query: 101 GAVELWELDENETLIVSKFCKYE-HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVV 159 V LW T V++ C D V++V G G+ +++WD A Sbjct: 207 TCVYLWSAC---TSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKK 263 Query: 160 LSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLA 219 LS H A+V +A + + S S D IL D R P S+ L Sbjct: 264 LSMLEGHTARVGALAWNAEQ---LSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLK 320 Query: 220 WHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLS--ED 277 W ++ G + + + + S S V H V + +SPH LAS D Sbjct: 321 WSTDH-QLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTAD 379 Query: 278 CSLAVLDSSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQ 321 + ++ + + V + WS + L++T G+ Sbjct: 380 RCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQN 423 Score = 118 bits (296), Expect = 3e-27, Method: Composition-based stats. Identities = 45/218 (20%), Positives = 76/218 (34%), Gaps = 10/218 (4%) Query: 81 AGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQA 140 A V L W E+ + S + ++ + S+ H V + + Sbjct: 272 ARVGALAWNAEQ-LSSGSRDRMILQRDIR--TPPLQSERRLQGHRQEVCGLKWSTDHQLL 328 Query: 141 VSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCS--EDNRILLWDTR 198 SG D + VW+ + + Y H A V +A SPH+ + S D I W+T Sbjct: 329 ASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTL 388 Query: 199 CPKPASQIGCSAPGYLPTSLAWHPQQSEVFVF-GDENGTVSLVDTKSTSCVLSSAVHSQC 257 +P I G +LAW +E+ G + + S + V HS Sbjct: 389 TGQPLQCID---TGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYR 445 Query: 258 VTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQA 295 V L SP + + + D +L + ++ Sbjct: 446 VLYLAMSPDGEAIV-TGAGDETLRFWNVFSKTRSTKES 482 Score = 75.2 bits (183), Expect = 3e-14, Method: Composition-based stats. Identities = 36/154 (23%), Positives = 56/154 (36%), Gaps = 11/154 (7%) Query: 173 VAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGD 232 V S LS + LW + S G TS+ W + + + G Sbjct: 193 VDWSSLN---VLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGN-LVAVGT 248 Query: 233 ENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELF- 291 G V + D + + H+ V L ++ L+S S D + D L Sbjct: 249 HKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQ---LSSGSRDRMILQRDIRTPPLQS 305 Query: 292 --RSQAHRDFVRDATWSPLNHSLLTTVGWDHQVV 323 R Q HR V WS +H LL + G D++++ Sbjct: 306 ERRLQGHRQEVCGLKWS-TDHQLLASGGNDNKLL 338 Score = 48.6 bits (114), Expect = 4e-06, Method: Composition-based stats. Identities = 14/85 (16%), Positives = 31/85 (36%), Gaps = 7/85 (8%) Query: 77 VQTEAGVADLTWVGERGILV---ASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSV 133 + T + V +L W LV + +W+ + H V +++ Sbjct: 396 IDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKY----PSLTQVAKLTGHSYRVLYLAM 451 Query: 134 LSSGTQAVSGSKDICIKVWDLAQQV 158 G V+G+ D ++ W++ + Sbjct: 452 SPDGEAIVTGAGDETLRFWNVFSKT 476 >4LG8-A nrPDB Length = 354 Score = 154 bits (390), Expect = 4e-38, Method: Composition-based stats. Identities = 51/242 (21%), Positives = 95/242 (39%), Gaps = 10/242 (4%) Query: 84 ADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSG 143 DL IL V +++ + L K H V++V S S Sbjct: 77 LDLCPSDTNKILTGGADKNVVVFDKSSEQILATLK----GHTKKVTSVVFHPSQDLVFSA 132 Query: 144 SKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPA 203 S D I++W + + RAH + VT ++ LS S+D D + + Sbjct: 133 SPDATIRIWSVPNASCVQVVRAHESAVTGLSLHAT-GDYLLSSSDDQYWAFSDIQTGRVL 191 Query: 204 SQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVF 263 +++ G T +HP +F G + + + D K + V + HS +T + F Sbjct: 192 TKVTDETSGCSLTCAQFHP-DGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAF 250 Query: 264 SPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHRD--FVRDATWSPLNHSLLTTVGWDHQ 321 S + +LA+ ++D S+ + D + F++ + V+ + + + L G D Q Sbjct: 251 SENG-YYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFD-QSGTYLALGGTDVQ 308 Query: 322 VV 323 + Sbjct: 309 IY 310 Score = 133 bits (335), Expect = 9e-32, Method: Composition-based stats. Identities = 51/250 (20%), Positives = 94/250 (37%), Gaps = 22/250 (8%) Query: 36 YRSDGALLLGASSLSGRCWAGSLWLFKDPCAAPNEGFCSAGVQTEAGVADLTW-VGERGI 94 + S + + + R W+ PN E+ V L+ + Sbjct: 123 HPSQDLVFSASPDATIRIWS-----------VPNASCVQVVRAHESAVTGLSLHATGDYL 171 Query: 95 LVASDSGAVELWELDENETLIVSKFCKYEHDD-IVSTVSVLSSGTQAVSGSKDICIKVWD 153 L +SD W + +T V E ++ G +G+ D IK+WD Sbjct: 172 LSSSDDQ---YWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWD 228 Query: 154 LAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGY 213 L ++ ++++ H+ +T +A S + ++D+ + LWD R K + + Sbjct: 229 LKERTNVANFPGHSGPITSIAFS-ENGYYLATAADDSSVKLWDLRKLKNFKTLQLDN-NF 286 Query: 214 LPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLAS 273 SL + + + + G + V + K + +L HS TG+ F H+ F+AS Sbjct: 287 EVKSLIFDQSGTYLALGGTD---VQIYICKQWTEILHFTEHSGLTTGVAFGHHA-KFIAS 342 Query: 274 LSEDCSLAVL 283 D SL Sbjct: 343 TGMDRSLKFY 352 Score = 81.7 bits (200), Expect = 4e-16, Method: Composition-based stats. Identities = 35/219 (15%), Positives = 66/219 (30%), Gaps = 52/219 (23%) Query: 153 DLAQQVVLSSYRA-HAAQV---TCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGC 208 +L++ ++S+ H+A + + P + L+ D ++++D + + + Sbjct: 53 ELSKYRQVASHVGLHSASIPGILALDLCPSDTNKILTGGADKNVVVFDKSSEQILATLK- 111 Query: 209 SAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSV 268 TS+ +HP Q VF + T+ + + SCV H VTGL Sbjct: 112 -GHTKKVTSVVFHPSQDLVF-SASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGD 169 Query: 269 PFLAS-------------------------------------------LSEDCSLAVLDS 285 L+S + D + + D Sbjct: 170 YLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDL 229 Query: 286 SLS-ELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQVV 323 + H + +S N L T D V Sbjct: 230 KERTNVANFPGHSGPITSIAFS-ENGYYLATAADDSSVK 267 Score = 32.8 bits (73), Expect = 0.25, Method: Composition-based stats. Identities = 14/110 (12%), Positives = 29/110 (26%), Gaps = 38/110 (34%) Query: 83 VADLTWVGERGIL-VASDSGAVELWELDENETLIVSKFCK-------------------- 121 + + + L A+D +V+LW+L + + + Sbjct: 245 ITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGG 304 Query: 122 -----------------YEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDL 154 EH + + V+ S D +K + L Sbjct: 305 TDVQIYICKQWTEILHFTEHSGLTTGVAFGHHAKFIASTGMDRSLKFYSL 354 >5FL8-q nrPDB Length = 515 Score = 154 bits (389), Expect = 5e-38, Method: Composition-based stats. Identities = 49/223 (21%), Positives = 85/223 (38%), Gaps = 15/223 (6%) Query: 117 SKFCKYEHDDIVSTVSVLS-SGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAA 175 S H + + + ++ V+G+ D ++WD Q + + + H V CV+ Sbjct: 135 SSSAIAGHGSTILCSAFAPHTSSRMVTGAGDNTARIWDCDTQTPMHTLKGHYNWVLCVSW 194 Query: 176 SPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQ------SEVFV 229 SP V + S DN I LWD + + TSL+W P Sbjct: 195 SPD-GEVIATGSMDNTIRLWDPKSGQCLGD-ALRGHSKWITSLSWEPIHLVKPGSKPRLA 252 Query: 230 FGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSE 289 ++GT+ + DT S C + + H+ V+ + + L S S D ++ V D + Sbjct: 253 SSSKDGTIKIWDTVSRVCQYTMSGHTNSVSCVKWG--GQGLLYSGSHDRTVRVWDINSQG 310 Query: 290 --LFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQVVHHVVPTE 330 + ++H +V + S L +DH P E Sbjct: 311 RCINILKSHAHWVNHLSLS--TDYALRIGAFDHTGKKPSTPEE 351 Score = 145 bits (365), Expect = 3e-35, Method: Composition-based stats. Identities = 49/280 (17%), Positives = 89/280 (31%), Gaps = 57/280 (20%) Query: 92 RGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKV 151 ++ + +W+ D + K H + V VS G +GS D I++ Sbjct: 157 SRMVTGAGDNTARIWDCDTQTPMHTLK----GHYNWVLCVSWSPDGEVIATGSMDNTIRL 212 Query: 152 WDLAQQVVLSS-YRAHAAQVTCVAAS------PHKDSVFLSCSEDNRILLWDTRCPKPAS 204 WD L R H+ +T ++ P S S+D I +WDT Sbjct: 213 WDPKSGQCLGDALRGHSKWITSLSWEPIHLVKPGSKPRLASSSKDGTIKIWDTVSRVC-- 270 Query: 205 QIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKS-TSCVLSSAVHSQCVTGLVF 263 Q S + + W + G + TV + D S C+ H+ V L Sbjct: 271 QYTMSGHTNSVSCVKW--GGQGLLYSGSHDRTVRVWDINSQGRCINILKSHAHWVNHLSL 328 Query: 264 S--------------------------------------PHSVPFLASLSEDCSLAVLD- 284 S +S + + S+D ++ + + Sbjct: 329 STDYALRIGAFDHTGKKPSTPEEAQKKALENYEKICKKNGNSEEMMVTASDDYTMFLWNP 388 Query: 285 -SSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQVV 323 S + R H+ V +SP + + + +D+ + Sbjct: 389 LKSTKPIARMTGHQKLVNHVAFSP-DGRYIVSASFDNSIK 427 Score = 141 bits (354), Expect = 6e-34, Method: Composition-based stats. Identities = 55/306 (17%), Positives = 111/306 (36%), Gaps = 61/306 (19%) Query: 68 PNEGFCS-AGVQTEAG-VADLTWVG--------ERGILVASDSGAVELWELDENETLIVS 117 P G C ++ + + L+W + + +S G +++W+ V Sbjct: 215 PKSGQCLGDALRGHSKWITSLSWEPIHLVKPGSKPRLASSSKDGTIKIWD----TVSRVC 270 Query: 118 KFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQ-QVVLSSYRAHAAQVTCVAA- 175 ++ H + VS V G SGS D ++VWD+ ++ ++HA V ++ Sbjct: 271 QYTMSGHTNSVSCVKWGGQG-LLYSGSHDRTVRVWDINSQGRCINILKSHAHWVNHLSLS 329 Query: 176 -------------------------------------SPHKDSVFLSCSEDNRILLWD-T 197 + + + + ++ S+D + LW+ Sbjct: 330 TDYALRIGAFDHTGKKPSTPEEAQKKALENYEKICKKNGNSEEMMVTASDDYTMFLWNPL 389 Query: 198 RCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQC 257 + KP +++ + L +A+ P V + ++ L D + + + H Sbjct: 390 KSTKPIARM--TGHQKLVNHVAFSP-DGRYIVSASFDNSIKLWDGRDGKFISTFRGHVAS 446 Query: 258 VTGLVFSPHSVPFLASLSEDCSLAVLDSSLSEL-FRSQAHRDFVRDATWSPLNHSLLTTV 316 V + +S L S S+D +L V D +L H+D V WS ++ + + Sbjct: 447 VYQVAWS-SDCRLLVSCSKDTTLKVWDVRTRKLSVDLPGHKDEVYTVDWS-VDGKRVCSG 504 Query: 317 GWDHQV 322 G D V Sbjct: 505 GKDKMV 510 Score = 124 bits (312), Expect = 5e-29, Method: Composition-based stats. Identities = 39/151 (25%), Positives = 62/151 (41%), Gaps = 7/151 (4%) Query: 90 GERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICI 149 E ++ ASD + LW ++ I H +V+ V+ G VS S D I Sbjct: 370 SEEMMVTASDDYTMFLWNPLKSTKPIA---RMTGHQKLVNHVAFSPDGRYIVSASFDNSI 426 Query: 150 KVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCS 209 K+WD +S++R H A V VA S + +SCS+D + +WD R K + Sbjct: 427 KLWDGRDGKFISTFRGHVASVYQVAWSSDCR-LLVSCSKDTTLKVWDVRTRKL--SVDLP 483 Query: 210 APGYLPTSLAWHPQQSEVFVFGDENGTVSLV 240 ++ W + G ++ V L Sbjct: 484 GHKDEVYTVDWSV-DGKRVCSGGKDKMVRLW 513 Score = 114 bits (284), Expect = 7e-26, Method: Composition-based stats. Identities = 43/241 (17%), Positives = 77/241 (31%), Gaps = 48/241 (19%) Query: 83 VADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVS---------- 132 V+ + W G+ + S V +W+++ I H V+ +S Sbjct: 281 VSCVKWGGQGLLYSGSHDRTVRVWDINSQGRCIN---ILKSHAHWVNHLSLSTDYALRIG 337 Query: 133 -VLSSGTQ----------------------------AVSGSKDICIKVWD-LAQQVVLSS 162 +G + V+ S D + +W+ L ++ Sbjct: 338 AFDHTGKKPSTPEEAQKKALENYEKICKKNGNSEEMMVTASDDYTMFLWNPLKSTKPIAR 397 Query: 163 YRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHP 222 H V VA SP +S S DN I LWD R K S +AW Sbjct: 398 MTGHQKLVNHVAFSPD-GRYIVSASFDNSIKLWDGRDGKFISTFR--GHVASVYQVAWSS 454 Query: 223 QQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAV 282 + V ++ T+ + D ++ + H V + +S + S +D + + Sbjct: 455 -DCRLLVSCSKDTTLKVWDVRTRKLSVDLPGHKDEVYTVDWSVDG-KRVCSGGKDKMVRL 512 Query: 283 L 283 Sbjct: 513 W 513 Score = 97.1 bits (240), Expect = 1e-20, Method: Composition-based stats. Identities = 23/133 (17%), Positives = 47/133 (35%), Gaps = 9/133 (6%) Query: 199 CPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCV 258 P S + G A+ P S V G + T + D + + + + H V Sbjct: 130 KPVTRSSSAIAGHGSTILCSAFAPHTSSRMVTGAGDNTARIWDCDTQTPMHTLKGHYNWV 189 Query: 259 TGLVFSPHSVPFLASLSEDCSLAVLDSSLSELF--RSQAHRDFVRDATWSPLN------H 310 + +SP +A+ S D ++ + D + + H ++ +W P++ Sbjct: 190 LCVSWSPDGE-VIATGSMDNTIRLWDPKSGQCLGDALRGHSKWITSLSWEPIHLVKPGSK 248 Query: 311 SLLTTVGWDHQVV 323 L + D + Sbjct: 249 PRLASSSKDGTIK 261 >5Z56-q nrPDB Length = 504 Score = 154 bits (389), Expect = 6e-38, Method: Composition-based stats. Identities = 51/242 (21%), Positives = 95/242 (39%), Gaps = 10/242 (4%) Query: 84 ADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSG 143 DL IL V +++ + L K H V++V S S Sbjct: 227 LDLCPSDTNKILTGGADKNVVVFDKSSEQILATLK----GHTKKVTSVVFHPSQDLVFSA 282 Query: 144 SKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPA 203 S D I++W + + RAH + VT ++ LS S+D D + + Sbjct: 283 SPDATIRIWSVPNASCVQVVRAHESAVTGLSLHAT-GDYLLSSSDDQYWAFSDIQTGRVL 341 Query: 204 SQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVF 263 +++ G T +HP +F G + + + D K + V + HS +T + F Sbjct: 342 TKVTDETSGCSLTCAQFHP-DGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAF 400 Query: 264 SPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHRD--FVRDATWSPLNHSLLTTVGWDHQ 321 S + +LA+ ++D S+ + D + F++ + V+ + + + L G D Q Sbjct: 401 SENG-YYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFD-QSGTYLALGGTDVQ 458 Query: 322 VV 323 + Sbjct: 459 IY 460 Score = 133 bits (334), Expect = 1e-31, Method: Composition-based stats. Identities = 51/250 (20%), Positives = 94/250 (37%), Gaps = 22/250 (8%) Query: 36 YRSDGALLLGASSLSGRCWAGSLWLFKDPCAAPNEGFCSAGVQTEAGVADLTW-VGERGI 94 + S + + + R W+ PN E+ V L+ + Sbjct: 273 HPSQDLVFSASPDATIRIWS-----------VPNASCVQVVRAHESAVTGLSLHATGDYL 321 Query: 95 LVASDSGAVELWELDENETLIVSKFCKYEHDD-IVSTVSVLSSGTQAVSGSKDICIKVWD 153 L +SD W + +T V E ++ G +G+ D IK+WD Sbjct: 322 LSSSDDQ---YWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWD 378 Query: 154 LAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGY 213 L ++ ++++ H+ +T +A S + ++D+ + LWD R K + + Sbjct: 379 LKERTNVANFPGHSGPITSIAFS-ENGYYLATAADDSSVKLWDLRKLKNFKTLQLDN-NF 436 Query: 214 LPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLAS 273 SL + + + + G + V + K + +L HS TG+ F H+ F+AS Sbjct: 437 EVKSLIFDQSGTYLALGGTD---VQIYICKQWTEILHFTEHSGLTTGVAFGHHA-KFIAS 492 Query: 274 LSEDCSLAVL 283 D SL Sbjct: 493 TGMDRSLKFY 502 Score = 81.3 bits (199), Expect = 5e-16, Method: Composition-based stats. Identities = 35/219 (15%), Positives = 66/219 (30%), Gaps = 52/219 (23%) Query: 153 DLAQQVVLSSYRA-HAAQV---TCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGC 208 +L++ ++S+ H+A + + P + L+ D ++++D + + + Sbjct: 203 ELSKYRQVASHVGLHSASIPGILALDLCPSDTNKILTGGADKNVVVFDKSSEQILATLK- 261 Query: 209 SAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSV 268 TS+ +HP Q VF + T+ + + SCV H VTGL Sbjct: 262 -GHTKKVTSVVFHPSQDLVF-SASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGD 319 Query: 269 PFLAS-------------------------------------------LSEDCSLAVLDS 285 L+S + D + + D Sbjct: 320 YLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDL 379 Query: 286 SLS-ELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQVV 323 + H + +S N L T D V Sbjct: 380 KERTNVANFPGHSGPITSIAFS-ENGYYLATAADDSSVK 417 Score = 32.4 bits (72), Expect = 0.26, Method: Composition-based stats. Identities = 14/110 (12%), Positives = 29/110 (26%), Gaps = 38/110 (34%) Query: 83 VADLTWVGERGIL-VASDSGAVELWELDENETLIVSKFCK-------------------- 121 + + + L A+D +V+LW+L + + + Sbjct: 395 ITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGG 454 Query: 122 -----------------YEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDL 154 EH + + V+ S D +K + L Sbjct: 455 TDVQIYICKQWTEILHFTEHSGLTTGVAFGHHAKFIASTGMDRSLKFYSL 504 >6ID0-T nrPDB Length = 514 Score = 153 bits (387), Expect = 9e-38, Method: Composition-based stats. Identities = 47/199 (23%), Positives = 75/199 (37%), Gaps = 7/199 (3%) Query: 123 EHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSV 182 H V ++V V+GS D IK+WDLA + S H + V V S + Sbjct: 202 GHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYL 261 Query: 183 FLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDT 242 F SC ED ++ WD K L HP +V V + T + D Sbjct: 262 F-SCGEDKQVKCWDLEYNKVIR--HYHGHLSAVYGLDLHP-TIDVLVTCSRDSTARIWDV 317 Query: 243 KSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSEL-FRSQAHRDFVR 301 ++ + V + + H+ V V + P + + S D ++ + D + H+ VR Sbjct: 318 RTKASVHTLSGHTNAV-ATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVR 376 Query: 302 DATWSPLNHSLLTTVGWDH 320 P H + D+ Sbjct: 377 AVVLHP-RHYTFASGSPDN 394 Score = 134 bits (337), Expect = 5e-32, Method: Composition-based stats. Identities = 49/238 (20%), Positives = 86/238 (36%), Gaps = 18/238 (7%) Query: 90 GERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICI 149 G + + S +++W+L + K H V V V + S +D + Sbjct: 215 GNQWFVTGSADRTIKIWDLASGK----LKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQV 270 Query: 150 KVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCS 209 K WDL V+ Y H + V + P D V ++CS D+ +WD R + S Sbjct: 271 KCWDLEYNKVIRHYHGHLSAVYGLDLHPTID-VLVTCSRDSTARIWDVRTKASVHTL--S 327 Query: 210 APGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVP 269 ++ + + + G + T+ L D + ++ H + V +V P Sbjct: 328 GHTNAVATVRCQAAEPQ-IITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYT 386 Query: 270 FLASLSEDCSLAVL---DSSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQVVH 324 F AS S D + D S + H + T + + G D+ +H Sbjct: 387 F-ASGSPDN-IKQWKFPDGSFIQNLS--GHNAIINTLTVNSDG---VLVSGADNGTMH 437 Score = 126 bits (317), Expect = 1e-29, Method: Composition-based stats. Identities = 38/241 (15%), Positives = 87/241 (36%), Gaps = 21/241 (8%) Query: 94 ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWD 153 + + V+ W+L+ N+ + H V + + + V+ S+D ++WD Sbjct: 261 LFSCGEDKQVKCWDLEYNKVIRHYH----GHLSAVYGLDLHPTIDVLVTCSRDSTARIWD 316 Query: 154 LAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGY 213 + + + + H V V + + ++ S D I LWD K +++ + Sbjct: 317 VRTKASVHTLSGHTNAVATVRCQAAEPQI-ITGSHDTTIRLWDLVAGK--TRVTLTNHKK 373 Query: 214 LPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLAS 273 ++ HP+ F G + + S + + + H+ + L + V L S Sbjct: 374 SVRAVVLHPRH-YTFASGSPDN-IKQWKFPDGSFIQNLSGHNAIINTLTVNSDGV--LVS 429 Query: 274 LSEDCSLAVLDSSLSELFR---------SQAHRDFVRDATWSPLNHSLLTTVGWDHQVVH 324 +++ ++ + D F+ S + + + S L T D + Sbjct: 430 GADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFD-QSESRLLTAEADKTIKV 488 Query: 325 H 325 + Sbjct: 489 Y 489 Score = 103 bits (257), Expect = 1e-22, Method: Composition-based stats. Identities = 30/166 (18%), Positives = 54/166 (32%), Gaps = 7/166 (4%) Query: 158 VVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTS 217 + H V C+A P + F++ S D I +WD K ++ + Sbjct: 195 KLYRVISGHLGWVRCIAVEP-GNQWFVTGSADRTIKIWDLASGKL--KLSLTGHISTVRG 251 Query: 218 LAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSED 277 + + +F G E+ V D + + H V GL P ++ L + S D Sbjct: 252 VIVSTRSPYLFSCG-EDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHP-TIDVLVTCSRD 309 Query: 278 CSLAVLDSSLS-ELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQV 322 + + D + H + V + T D + Sbjct: 310 STARIWDVRTKASVHTLSGHTNAVATVRCQAAE-PQIITGSHDTTI 354 Score = 84.0 bits (206), Expect = 9e-17, Method: Composition-based stats. Identities = 28/155 (18%), Positives = 52/155 (33%), Gaps = 12/155 (7%) Query: 91 ERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIK 150 E I+ S + LW+L +T + H V V + SGS D IK Sbjct: 342 EPQIITGSHDTTIRLWDLVAGKT----RVTLTNHKKSVRAVVLHPRHYTFASGSPDN-IK 396 Query: 151 VWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSA 210 W + + H A + + + V +S +++ + LWD R ++ + Sbjct: 397 QWKFPDGSFIQNLSGHNAIINTLTVNSDG--VLVSGADNGTMHLWDWRTGYNFQRVHAAV 454 Query: 211 PGYLPTS-----LAWHPQQSEVFVFGDENGTVSLV 240 S Q + + + T+ + Sbjct: 455 QPGSLDSESGIFACAFDQSESRLLTAEADKTIKVY 489 Score = 27.8 bits (60), Expect = 7.5, Method: Composition-based stats. Identities = 8/50 (16%), Positives = 12/50 (24%), Gaps = 1/50 (2%) Query: 283 LDSSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQVVHHVVPTEPL 332 H +VR P N T D + + + L Sbjct: 190 WHPPWKLYRVISGHLGWVRCIAVEPGNQ-WFVTGSADRTIKIWDLASGKL 238 >5A31-R nrPDB Length = 386 Score = 152 bits (384), Expect = 2e-37, Method: Composition-based stats. Identities = 56/293 (19%), Positives = 112/293 (38%), Gaps = 18/293 (6%) Query: 28 ERQLEAARYRSDGALLLGASSLSGRCWAGSLWLFKDPCAAPNEGFCSAGVQTEAGVADLT 87 + Q Y L S+ S + + P + + + + + Sbjct: 45 KVQKGLFTYSLSPYSLSPVSNKSQKLLRS-----RQIAKVPYRVLDAPSLADDFYYSLID 99 Query: 88 WVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDI 147 W + VA L +N T V C E++ +++S + +G+ G + Sbjct: 100 WSSTDVLAVALGKSIF----LTDNNTGDVVHLCDTENE--YTSLSWIGAGSHLAVGQANG 153 Query: 148 CIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIG 207 ++++D+ ++ + + H +V C++ + + V S S D+RIL D R P P + Sbjct: 154 LVEIYDVMKRKCIRTLSGHIDRVACLSWN---NHVLTSGSRDHRILHRDVRMPDPFFETI 210 Query: 208 CSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHS 267 S L W+ ++ G + V + + S S +L+ H V + +SPH Sbjct: 211 ES-HTQEVCGLKWNVADNK-LASGGNDNVVHVYEGTSKSPILTFDEHKAAVKAMAWSPHK 268 Query: 268 VPFLASLS--EDCSLAVLDSSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGW 318 LA+ D L + + + S + + WS + L+T+ G+ Sbjct: 269 RGVLATGGGTADRRLKIWNVNTSIKMSDIDSGSQICNMVWSKNTNELVTSHGY 321 Score = 96.7 bits (239), Expect = 1e-20, Method: Composition-based stats. Identities = 41/216 (18%), Positives = 74/216 (34%), Gaps = 12/216 (5%) Query: 72 FCSAGVQTEA-GVADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVST 130 C + VA L+W + S + ++ + + H V Sbjct: 164 KCIRTLSGHIDRVACLSW-NNHVLTSGSRDHRILHRDVRMPDPFFET---IESHTQEVCG 219 Query: 131 VSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCS--E 188 + + + SG D + V++ + + ++ H A V +A SPHK V + Sbjct: 220 LKWNVADNKLASGGNDNVVHVYEGTSKSPILTFDEHKAAVKAMAWSPHKRGVLATGGGTA 279 Query: 189 DNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVF-GDENGTVSLVDTKSTSC 247 D R+ +W+ S I G ++ W +E+ G ++L D S Sbjct: 280 DRRLKIWNVNTSIKMSDID---SGSQICNMVWSKNTNELVTSHGYSKYNLTLWDCNSMDP 336 Query: 248 VLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVL 283 + HS V L S + S + D +L Sbjct: 337 IAILKGHSFRVLHLTLSNDGTT-VVSGAGDETLRYW 371 Score = 54.0 bits (128), Expect = 1e-07, Method: Composition-based stats. Identities = 18/124 (14%), Positives = 48/124 (38%), Gaps = 12/124 (9%) Query: 80 EAGVADLTWV-GERGILV---ASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLS 135 +A V + W +RG+L + +++W ++ + K + + + Sbjct: 256 KAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTS-----IKMSDIDSGSQICNMVWSK 310 Query: 136 SGTQAVS--GSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRIL 193 + + V+ G + +WD ++ + H+ +V + S + + +S + D + Sbjct: 311 NTNELVTSHGYSKYNLTLWDCNSMDPIAILKGHSFRVLHLTLS-NDGTTVVSGAGDETLR 369 Query: 194 LWDT 197 W Sbjct: 370 YWKL 373 Score = 42.8 bits (99), Expect = 2e-04, Method: Composition-based stats. Identities = 18/89 (20%), Positives = 38/89 (42%), Gaps = 7/89 (7%) Query: 69 NEGFCSAGVQTEAGVADLTWVGERGILVAS---DSGAVELWELDENETLIVSKFCKYEHD 125 N + + + + + ++ W LV S + LW+ + + + + K H Sbjct: 289 NTSIKMSDIDSGSQICNMVWSKNTNELVTSHGYSKYNLTLWDCNSMDPIAILK----GHS 344 Query: 126 DIVSTVSVLSSGTQAVSGSKDICIKVWDL 154 V +++ + GT VSG+ D ++ W L Sbjct: 345 FRVLHLTLSNDGTTVVSGAGDETLRYWKL 373 >4BH6-A nrPDB Length = 308 Score = 149 bits (377), Expect = 1e-36, Method: Composition-based stats. Identities = 52/260 (20%), Positives = 105/260 (40%), Gaps = 13/260 (5%) Query: 61 FKDPCAAPNEGFCSAGVQTEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFC 120 F+ P + + + + + W + VA L +N T V C Sbjct: 4 FRQIAKVPYRVLDAPSLADDFYYSLIDWSSTDVLAVALGKSIF----LTDNNTGDVVHLC 59 Query: 121 KYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKD 180 E++ +++S + +G+ G + ++++D+ ++ + + H +V C++ + + Sbjct: 60 DTENE--YTSLSWIGAGSHLAVGQANGLVEIYDVMKRKCIRTLSGHIDRVACLSWN---N 114 Query: 181 SVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLV 240 V S S D+RIL D R P P + S L W+ ++ G + V + Sbjct: 115 HVLTSGSRDHRILHRDVRMPDPFFETIES-HTQEVCGLKWNVADNK-LASGGNDNVVHVY 172 Query: 241 DTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLS--EDCSLAVLDSSLSELFRSQAHRD 298 + S S +L+ H V + +SPH LA+ D L + + + S Sbjct: 173 EGTSKSPILTFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDIDSGS 232 Query: 299 FVRDATWSPLNHSLLTTVGW 318 + + WS + L+T+ G+ Sbjct: 233 QICNMVWSKNTNELVTSHGY 252 Score = 95.2 bits (235), Expect = 4e-20, Method: Composition-based stats. Identities = 41/216 (18%), Positives = 74/216 (34%), Gaps = 12/216 (5%) Query: 72 FCSAGVQTEA-GVADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVST 130 C + VA L+W + S + ++ + + H V Sbjct: 95 KCIRTLSGHIDRVACLSW-NNHVLTSGSRDHRILHRDVRMPDPFFET---IESHTQEVCG 150 Query: 131 VSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCS--E 188 + + + SG D + V++ + + ++ H A V +A SPHK V + Sbjct: 151 LKWNVADNKLASGGNDNVVHVYEGTSKSPILTFDEHKAAVKAMAWSPHKRGVLATGGGTA 210 Query: 189 DNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVF-GDENGTVSLVDTKSTSC 247 D R+ +W+ S I G ++ W +E+ G ++L D S Sbjct: 211 DRRLKIWNVNTSIKMSDID---SGSQICNMVWSKNTNELVTSHGYSKYNLTLWDCNSMDP 267 Query: 248 VLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVL 283 + HS V L S + S + D +L Sbjct: 268 IAILKGHSFRVLHLTLSNDGTT-VVSGAGDETLRYW 302 Score = 53.2 bits (126), Expect = 2e-07, Method: Composition-based stats. Identities = 18/124 (14%), Positives = 48/124 (38%), Gaps = 12/124 (9%) Query: 80 EAGVADLTWV-GERGILV---ASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLS 135 +A V + W +RG+L + +++W ++ + K + + + Sbjct: 187 KAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTS-----IKMSDIDSGSQICNMVWSK 241 Query: 136 SGTQAVS--GSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRIL 193 + + V+ G + +WD ++ + H+ +V + S + + +S + D + Sbjct: 242 NTNELVTSHGYSKYNLTLWDCNSMDPIAILKGHSFRVLHLTLS-NDGTTVVSGAGDETLR 300 Query: 194 LWDT 197 W Sbjct: 301 YWKL 304 Score = 42.4 bits (98), Expect = 3e-04, Method: Composition-based stats. Identities = 18/89 (20%), Positives = 38/89 (42%), Gaps = 7/89 (7%) Query: 69 NEGFCSAGVQTEAGVADLTWVGERGILVAS---DSGAVELWELDENETLIVSKFCKYEHD 125 N + + + + + ++ W LV S + LW+ + + + + K H Sbjct: 220 NTSIKMSDIDSGSQICNMVWSKNTNELVTSHGYSKYNLTLWDCNSMDPIAILK----GHS 275 Query: 126 DIVSTVSVLSSGTQAVSGSKDICIKVWDL 154 V +++ + GT VSG+ D ++ W L Sbjct: 276 FRVLHLTLSNDGTTVVSGAGDETLRYWKL 304 >4XYI-A nrPDB Length = 430 Score = 148 bits (373), Expect = 4e-36, Method: Composition-based stats. Identities = 50/216 (23%), Positives = 89/216 (41%), Gaps = 28/216 (12%) Query: 132 SVLSSGTQAVSGSKDICIKVWDLAQQVV----------LSSYRAHAAQVTCVAASPHKDS 181 + + GT +G++D I VWD+ + + +S Y H A V + ++ Sbjct: 191 NFIQEGT-LATGTEDTSICVWDIKGKSLSLEKSIDVAPVSVYHRHTAVVNDLQFHLQHEA 249 Query: 182 VFLSCSEDNRILLWDTRCPKPASQIGC-SAPGYLPTSLAWHPQQSEVFVFGDENGTVSLV 240 + S S+D + + DTR P +S C A +A++P + + TV+L Sbjct: 250 LLTSVSDDCTLQIHDTRLPSSSSASQCVKAHEQPVNGVAFNPFNDYLLATASADHTVALW 309 Query: 241 DTKS-TSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLD-SSLSELFRSQ---- 294 D + + + H V + +SPH P L + S D + V D S + E + Sbjct: 310 DLRRLNQRLHTLEGHEDEVYNVQWSPHDEPILVTSSTDRRVCVWDLSKIGEEQTVEDSED 369 Query: 295 ----------AHRDFVRDATWSPLNHSLLTTVGWDH 320 H + V D +W+P N +L ++ D+ Sbjct: 370 GAPELMFMHGGHTNRVSDLSWNPNNKWVLASLADDN 405 Score = 135 bits (340), Expect = 3e-32, Method: Composition-based stats. Identities = 43/221 (19%), Positives = 87/221 (39%), Gaps = 22/221 (9%) Query: 124 HDDIVSTVSVLSSG-TQAVSGSKDICIKVWDL---AQQVVLSS-----YRAHAAQVTCVA 174 H+ V+ + + + ++DL +Q ++ + R H ++ + Sbjct: 130 HEGDVNKARFMPQNPDIIATLGLNGNGYIFDLNLYREQPIVQTGHQACLRHHTSEGFGLG 189 Query: 175 ASPHKDSVFLSCSEDNRILLWDTRCPKPASQIG--------CSAPGYLPTSLAWHPQQSE 226 + ++ + +ED I +WD + + + + L +H Q Sbjct: 190 WNFIQEGTLATGTEDTSICVWDIKGKSLSLEKSIDVAPVSVYHRHTAVVNDLQFHLQHEA 249 Query: 227 VFVFGDENGTVSLVDTK---STSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVL 283 + ++ T+ + DT+ S+S H Q V G+ F+P + LA+ S D ++A+ Sbjct: 250 LLTSVSDDCTLQIHDTRLPSSSSASQCVKAHEQPVNGVAFNPFNDYLLATASADHTVALW 309 Query: 284 DSS--LSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQV 322 D L + H D V + WSP + +L T D +V Sbjct: 310 DLRRLNQRLHTLEGHEDEVYNVQWSPHDEPILVTSSTDRRV 350 Score = 119 bits (297), Expect = 2e-27, Method: Composition-based stats. Identities = 51/305 (16%), Positives = 108/305 (35%), Gaps = 27/305 (8%) Query: 5 TPPPLVPPAAR-EWNLPPNAPACMERQLEAARYRSDGALLLGASSLSGRCWAGSLWLFKD 63 TP + P + ++ L E + AR+ ++ L+G + L L+++ Sbjct: 107 TPSKMKPANFKGDYGLDIVQKIHHEGDVNKARFMPQNPDIIATLGLNGNGYIFDLNLYRE 166 Query: 64 -PCAAPNEGFCSAGVQTEAGVADLTWVGERGILVASDSGAVELWELDEN-----ETLIVS 117 P C +E ++ E + ++ ++ +W++ +++ V+ Sbjct: 167 QPIVQTGHQACLRHHTSEGFGLGWNFIQEGTLATGTEDTSICVWDIKGKSLSLEKSIDVA 226 Query: 118 KFCKY-EHDDIVSTVSVLSSGTQAVSG-SKDICIKVWDLA---QQVVLSSYRAHAAQVTC 172 Y H +V+ + ++ S D +++ D +AH V Sbjct: 227 PVSVYHRHTAVVNDLQFHLQHEALLTSVSDDCTLQIHDTRLPSSSSASQCVKAHEQPVNG 286 Query: 173 VAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGD 232 VA +P D + + S D+ + LWD R ++ W P + V Sbjct: 287 VAFNPFNDYLLATASADHTVALWDLRRLNQ-RLHTLEGHEDEVYNVQWSPHDEPILVTSS 345 Query: 233 ENGTVSLVDTKSTSCVLSSA--------------VHSQCVTGLVFSPHSVPFLASLSEDC 278 + V + D + H+ V+ L ++P++ LASL++D Sbjct: 346 TDRRVCVWDLSKIGEEQTVEDSEDGAPELMFMHGGHTNRVSDLSWNPNNKWVLASLADDN 405 Query: 279 SLAVL 283 L + Sbjct: 406 ILQIW 410 Score = 115 bits (288), Expect = 2e-26, Method: Composition-based stats. Identities = 42/234 (17%), Positives = 79/234 (33%), Gaps = 27/234 (11%) Query: 36 YRSDGALLLGASSLSGRCWAGS------LWLFKDPCAAPNEGFCSAGVQTEAG----VAD 85 + S+G L G G+ +W K + + A V V D Sbjct: 181 HTSEGFGLGWNFIQEGTLATGTEDTSICVWDIKGKSLSLEKSIDVAPVSVYHRHTAVVND 240 Query: 86 LTW--VGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAV-S 142 L + E + SD +++ + + S+ C H+ V+ V+ + + Sbjct: 241 LQFHLQHEALLTSVSDDCTLQIHDTRLPSSSSASQ-CVKAHEQPVNGVAFNPFNDYLLAT 299 Query: 143 GSKDICIKVWDLAQ-QVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDT---- 197 S D + +WDL + L + H +V V SPH + + ++ S D R+ +WD Sbjct: 300 ASADHTVALWDLRRLNQRLHTLEGHEDEVYNVQWSPHDEPILVTSSTDRRVCVWDLSKIG 359 Query: 198 --------RCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTK 243 P + L+W+P V ++ + + Sbjct: 360 EEQTVEDSEDGAPELMFMHGGHTNRVSDLSWNPNNKWVLASLADDNILQIWSPS 413 Score = 40.5 bits (93), Expect = 0.001, Method: Composition-based stats. Identities = 13/79 (16%), Positives = 24/79 (30%), Gaps = 9/79 (11%) Query: 253 VHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELF---------RSQAHRDFVRDA 303 H V F P + +A+L + + + D +L + H Sbjct: 129 HHEGDVNKARFMPQNPDIIATLGLNGNGYIFDLNLYREQPIVQTGHQACLRHHTSEGFGL 188 Query: 304 TWSPLNHSLLTTVGWDHQV 322 W+ + L T D + Sbjct: 189 GWNFIQEGTLATGTEDTSI 207 >5Y88-O nrPDB Length = 451 Score = 145 bits (366), Expect = 3e-35, Method: Composition-based stats. Identities = 42/199 (21%), Positives = 75/199 (37%), Gaps = 8/199 (4%) Query: 123 EHDDIVSTVSVLS-SGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDS 181 H V V++ ++GS D +KVWDLA + ++ H V VA S Sbjct: 137 GHLGWVRCVAIDPVDNEWFITGSNDTTMKVWDLATGKLKTTLAGHVMTVRDVAVSDRHPY 196 Query: 182 VFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVD 241 +F S SED + WD + +++ HP ++ + + L D Sbjct: 197 LF-SVSEDKTVKCWDLEKNQIIR--DYYGHLSGVRTVSIHPTL-DLIATAGRDSVIKLWD 252 Query: 242 TKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHRDF-V 300 ++ V++ H + + +P P + S S D ++ + D + + H V Sbjct: 253 MRTRIPVITLVGHKGPINQVQCTPVD-PQVVSSSTDATVRLWDVVAGKTMKVLTHHKRSV 311 Query: 301 RDATWSPLNHSLLTTVGWD 319 R P S + + D Sbjct: 312 RATALHPKEFS-VASACTD 329 Score = 124 bits (312), Expect = 4e-29, Method: Composition-based stats. Identities = 41/195 (21%), Positives = 70/195 (35%), Gaps = 10/195 (5%) Query: 89 VGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDIC 148 V + S+ +++W+L + K H V V+V S S+D Sbjct: 150 VDNEWFITGSNDTTMKVWDLATGK----LKTTLAGHVMTVRDVAVSDRHPYLFSVSEDKT 205 Query: 149 IKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGC 208 +K WDL + ++ Y H + V V+ P D + + D+ I LWD R P I Sbjct: 206 VKCWDLEKNQIIRDYYGHLSGVRTVSIHPTLD-LIATAGRDSVIKLWDMRTRIP--VITL 262 Query: 209 SAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSV 268 + P +V V + TV L D + + H + V P Sbjct: 263 VGHKGPINQVQCTPVDPQV-VSSSTDATVRLWDVVAGKTMKVLTHHKRSVRATALHPKEF 321 Query: 269 PFLASLSEDCSLAVL 283 ++ ++D + Sbjct: 322 SVASACTDD--IRSW 334 Score = 119 bits (299), Expect = 2e-27, Method: Composition-based stats. Identities = 49/251 (19%), Positives = 94/251 (37%), Gaps = 21/251 (8%) Query: 83 VADLTWVGER-GILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAV 141 V D+ + S+ V+ W+L++N+ + Y H V TVS+ + Sbjct: 185 VRDVAVSDRHPYLFSVSEDKTVKCWDLEKNQIIR----DYYGHLSGVRTVSIHPTLDLIA 240 Query: 142 SGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPK 201 + +D IK+WD+ ++ + + H + V +P V +S S D + LWD K Sbjct: 241 TAGRDSVIKLWDMRTRIPVITLVGHKGPINQVQCTPVDPQV-VSSSTDATVRLWDVVAGK 299 Query: 202 PASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSA-VHSQCVTG 260 + T+L HP++ V ++ + S + + + + Sbjct: 300 TMKVLTHHKRSVRATAL--HPKEFSVASACTDD--IRSWGLAEGSLLTNFESEKTGIINT 355 Query: 261 LVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHRDFV------RDATWSPLNHS--L 312 L + V L + ++ L+ D ++S A R+ V R S + + Sbjct: 356 LSINQDDV--LFAGGDNGVLSFYDYKSGHKYQSLATREMVGSLEGERSVLCSTFDKTGLR 413 Query: 313 LTTVGWDHQVV 323 L T D + Sbjct: 414 LITGEADKSIK 424 Score = 109 bits (272), Expect = 2e-24, Method: Composition-based stats. Identities = 28/166 (16%), Positives = 57/166 (34%), Gaps = 6/166 (3%) Query: 158 VVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTS 217 + H V CVA P + F++ S D + +WD K + + Sbjct: 130 KLSRVINGHLGWVRCVAIDPVDNEWFITGSNDTTMKVWDLATGKLKTTLA--GHVMTVRD 187 Query: 218 LAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSED 277 +A + +F E+ TV D + + H V + P ++ +A+ D Sbjct: 188 VAVSDRHPYLF-SVSEDKTVKCWDLEKNQIIRDYYGHLSGVRTVSIHP-TLDLIATAGRD 245 Query: 278 CSLAVLDSSLS-ELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQV 322 + + D + H+ + +P++ + + D V Sbjct: 246 SVIKLWDMRTRIPVITLVGHKGPINQVQCTPVD-PQVVSSSTDATV 290 Score = 56.7 bits (135), Expect = 2e-08, Method: Composition-based stats. Identities = 18/80 (22%), Positives = 27/80 (33%), Gaps = 2/80 (2%) Query: 245 TSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRS-QAHRDFVRDA 303 H V + P + + S D ++ V D + +L + H VRD Sbjct: 129 WKLSRVINGHLGWVRCVAIDPVDNEWFITGSNDTTMKVWDLATGKLKTTLAGHVMTVRDV 188 Query: 304 TWSPLNHSLLTTVGWDHQVV 323 S H L +V D V Sbjct: 189 AVS-DRHPYLFSVSEDKTVK 207 Score = 41.3 bits (95), Expect = 6e-04, Method: Composition-based stats. Identities = 14/100 (14%), Positives = 33/100 (33%), Gaps = 11/100 (11%) Query: 83 VADLTWVGERGILVASDSGAVELWELDENETLIVS----KFCKYEHDDIVSTVSVLSSGT 138 + L+ + + D+G + ++ E + V + +G Sbjct: 353 INTLSINQDDVLFAGGDNGVLSFYDYKSGHKYQSLATREMVGSLEGERSVLCSTFDKTGL 412 Query: 139 QAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPH 178 + ++G D IK+W + S +A +P+ Sbjct: 413 RLITGEADKSIKIWKQDETATKESEPG-------LAWNPN 445 Score = 32.0 bits (71), Expect = 0.36, Method: Composition-based stats. Identities = 8/50 (16%), Positives = 15/50 (30%) Query: 283 LDSSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQVVHHVVPTEPL 332 + H +VR P+++ T D + + T L Sbjct: 125 WHAPWKLSRVINGHLGWVRCVAIDPVDNEWFITGSNDTTMKVWDLATGKL 174 >3JB9-L nrPDB Length = 340 Score = 144 bits (364), Expect = 5e-35, Method: Composition-based stats. Identities = 41/241 (17%), Positives = 75/241 (31%), Gaps = 18/241 (7%) Query: 92 RGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKV 151 + LW + + ++ + S D + Sbjct: 63 SYFASGGMDRQILLWNVFGDVKNYG---VLNGCKGAITDLQWSRDSRVVYCSSSDTHLMS 119 Query: 152 WDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAP 211 WD + ++ HA V + + S S+D + +WD+R I Sbjct: 120 WDAVSGQKIRKHKGHAGVVNALDVLKVGSELLTSVSDDCTMKVWDSRSKDCIKTIEEK-- 177 Query: 212 GYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFL 271 Y T++A Q ++VF+ G +G + + D ++ C H +T L S L Sbjct: 178 -YPLTAVAIAQQGTQVFI-GGIDGAIKIWDLRNNHCSHVLKGHKDIITSLAISKDGSSLL 235 Query: 272 ASLSEDCSLAVLD-------SSLSELFR--SQAHRDFVRDATWSPLNHSLLTTVGWDHQV 322 S S D ++ + D ++F + WS N + D V Sbjct: 236 -SNSMDNTVRIFDVKPFASAQRQLQIFEGAIHGQEHNLLGVAWS-RNSRFVGAGSSDKNV 293 Query: 323 V 323 Sbjct: 294 Y 294 Score = 73.2 bits (178), Expect = 2e-13, Method: Composition-based stats. Identities = 25/117 (21%), Positives = 45/117 (38%), Gaps = 7/117 (5%) Query: 83 VADLTWVGE-RGILVASDSGAVELWELDENET----LIVSKFCKYEHDDIVSTVSVLSSG 137 + L + +L S V ++++ + L + + + + + V+ + Sbjct: 222 ITSLAISKDGSSLLSNSMDNTVRIFDVKPFASAQRQLQIFEGAIHGQEHNLLGVAWSRNS 281 Query: 138 TQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILL 194 +GS D + VW A + H V V PH+D + LSCS D I L Sbjct: 282 RFVGAGSSDKNVYVWS-ATGDLRYVLPGHEGSVNHVDFHPHQD-IILSCSSDRTIFL 336 >6HHQ-h nrPDB Length = 319 Score = 144 bits (362), Expect = 6e-35, Method: Composition-based stats. Identities = 43/229 (18%), Positives = 83/229 (36%), Gaps = 6/229 (2%) Query: 91 ERGILVASDSGAVELWELDENETLIVSKFCKY-EHDDIVSTVSVLSSGTQAVSGSKDICI 149 +L AS + W+L ++ + H IV ++ + G A+S S D + Sbjct: 30 PNLLLSASRDKTLISWKLTGDDQKFGVPVRSFKGHSHIVQDCTLTADGAYALSASWDKTL 89 Query: 150 KVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCS 209 ++WD+A + H + V V K S+ +S S D I +W + A+ +G + Sbjct: 90 RLWDVATGETYQRFVGHKSDVMSVDID-KKASMIISGSRDKTIKVWTIKGQCLATLLGHN 148 Query: 210 APGYLPTSL--AWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHS 267 + S + + V + H+ + L SP Sbjct: 149 DWVSQVRVVPNEKADDDSVTIISAGNDKMVKAWNLNQFQIEADFIGHNSNINTLTASPDG 208 Query: 268 VPFLASLSEDCSLAVLDSSLSELFRSQAHRDFVRDATWSPLNHSLLTTV 316 +AS +D + + + + + + + +D V +SP N L Sbjct: 209 T-LIASAGKDGEIMLWNLAAKKAMYTLSAQDEVFSLAFSP-NRYWLAAA 255 Score = 110 bits (274), Expect = 1e-24, Method: Composition-based stats. Identities = 35/227 (15%), Positives = 86/227 (37%), Gaps = 18/227 (7%) Query: 109 DENETLIVSKFCKYEHDDIVSTVSVL-SSGTQAVSGSKDICIKVW-----DLAQQVVLSS 162 + ++V + H+ V++++ +S S+D + W D V + S Sbjct: 1 MASNEVLVLRGTLEGHNGWVTSLATSAGQPNLLLSASRDKTLISWKLTGDDQKFGVPVRS 60 Query: 163 YRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHP 222 ++ H+ V + + LS S D + LWD + + + + Sbjct: 61 FKGHSHIVQDCTLTAD-GAYALSASWDKTLRLWDVATGETYQRFVGHKSDVMSVDID--- 116 Query: 223 QQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVP-----FLASLSED 277 +++ + + G + T+ + K C+ + H+ V+ + P+ + S D Sbjct: 117 KKASMIISGSRDKTIKVWTIK-GQCLATLLGHNDWVSQVRVVPNEKADDDSVTIISAGND 175 Query: 278 CSLAVLDSSLSELFR-SQAHRDFVRDATWSPLNHSLLTTVGWDHQVV 323 + + + ++ H + T SP + +L+ + G D +++ Sbjct: 176 KMVKAWNLNQFQIEADFIGHNSNINTLTASP-DGTLIASAGKDGEIM 221 Score = 55.1 bits (131), Expect = 4e-08, Method: Composition-based stats. Identities = 25/150 (16%), Positives = 47/150 (31%), Gaps = 53/150 (35%) Query: 94 ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWD 153 I+ A + V+ W L++ + + H+ ++T++ GT S KD I +W+ Sbjct: 169 IISAGNDKMVKAWNLNQFQ----IEADFIGHNSNINTLTASPDGTLIASAGKDGEIMLWN 224 Query: 154 LAQQVVLSSYRAHAAQVTCVAASPH----------------------------------- 178 LA + + + A +V +A SP+ Sbjct: 225 LAAKKAMYTLSA-QDEVFSLAFSPNRYWLAAATATGIKVFSLDPQYLVDDLRPEFAGYSK 283 Query: 179 -------------KDSVFLSCSEDNRILLW 195 + DN I +W Sbjct: 284 AAEPHAVSLAWSADGQTLFAGYTDNVIRVW 313 Score = 32.0 bits (71), Expect = 0.43, Method: Composition-based stats. Identities = 15/86 (17%), Positives = 35/86 (40%), Gaps = 6/86 (6%) Query: 76 GVQTEAGVADLTWVGERGILVASDSGAVELWELD-----ENETLIVSKFCKYEHDDIVST 130 + + V L + R L A+ + ++++ LD ++ + + K V + Sbjct: 233 TLSAQDEVFSLAFSPNRYWLAAATATGIKVFSLDPQYLVDDLRPEFAGYSKAAEPHAV-S 291 Query: 131 VSVLSSGTQAVSGSKDICIKVWDLAQ 156 ++ + G +G D I+VW + Sbjct: 292 LAWSADGQTLFAGYTDNVIRVWQVMT 317 >5WJC-A nrPDB Length = 430 Score = 144 bits (362), Expect = 6e-35, Method: Composition-based stats. Identities = 44/238 (18%), Positives = 87/238 (36%), Gaps = 28/238 (11%) Query: 111 NETLIVSKFCKYEHDDIVSTVSVLSSGT-QAVSGSKDICIKVWDLAQQV----------V 159 + + H + + +G++D I +WD+ Q Sbjct: 168 TTGEALPQAVLKGHTAEGFGLCWNPNLPGNLATGAEDQVICLWDVQTQSFTSSETKVISP 227 Query: 160 LSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTR-CPKPASQIGCSAPGYLPTSL 218 ++ Y H V V P +++ S S+D + + DTR P+ + A ++ Sbjct: 228 IAKYHRHTDIVNDVQFHPQHEALLASVSDDCTLQIHDTRLNPEEEAPKVIQAHSKAINAV 287 Query: 219 AWHPQQSEVFVFGDENGTVSLVDTKST-SCVLSSAVHSQCVTGLVFSPHSVPFLASLSED 277 A +P + + TV+L D ++ + + H V GL +SPH P LAS S D Sbjct: 288 AINPFNDYLLATASADKTVALWDLRNPYQRLHTLEGHEDEVYGLEWSPHDEPILASSSTD 347 Query: 278 CSLAVLDSSLSELFRSQ---------------AHRDFVRDATWSPLNHSLLTTVGWDH 320 + + D ++ H + + + +W P ++ ++ D+ Sbjct: 348 RRVCIWDLEKIGEEQTPEDAEDGSPELLFMHGGHTNRISEFSWCPNERWVVGSLADDN 405 Score = 139 bits (349), Expect = 2e-33, Method: Composition-based stats. Identities = 41/221 (18%), Positives = 81/221 (36%), Gaps = 22/221 (9%) Query: 124 HDDIVSTVSVLSSGTQAV-SGSKDICIKVWD------LAQQVVL--SSYRAHAAQVTCVA 174 HD V+ + + + + + ++D L L + + H A+ + Sbjct: 130 HDGDVNRARYMPQKPEIIATMGEGGNAYIFDTTCHDALTTGEALPQAVLKGHTAEGFGLC 189 Query: 175 ASPHKDSVFLSCSEDNRILLWDTRCPKPAS--------QIGCSAPGYLPTSLAWHPQQSE 226 +P+ + +ED I LWD + S + + +HPQ Sbjct: 190 WNPNLPGNLATGAEDQVICLWDVQTQSFTSSETKVISPIAKYHRHTDIVNDVQFHPQHEA 249 Query: 227 VFVFGDENGTVSLVDTK---STSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVL 283 + ++ T+ + DT+ HS+ + + +P + LA+ S D ++A+ Sbjct: 250 LLASVSDDCTLQIHDTRLNPEEEAPKVIQAHSKAINAVAINPFNDYLLATASADKTVALW 309 Query: 284 DSSL--SELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQV 322 D L + H D V WSP + +L + D +V Sbjct: 310 DLRNPYQRLHTLEGHEDEVYGLEWSPHDEPILASSSTDRRV 350 Score = 129 bits (324), Expect = 2e-30, Method: Composition-based stats. Identities = 46/262 (17%), Positives = 82/262 (31%), Gaps = 32/262 (12%) Query: 84 ADLTWVGERGILVASDS--GAVELWELDENETLIVSKFCKYEHDDIVSTVS-VLSSGTQA 140 + W+ ++ + +D + L + + + + S + Sbjct: 54 LTIQWLPDKKTIPGTDYSIQRLILGTHTSGNDQNYLQIASVQLPNFDEDTTEFTPSTIRR 113 Query: 141 VSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCP 200 + I++ S H V P K + + E ++DT C Sbjct: 114 AQATGSYTIEI---------SQKIPHDGDVNRARYMPQKPEIIATMGEGGNAYIFDTTCH 164 Query: 201 KPAS------QIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTS-------- 246 + Q L W+P G E+ + L D ++ S Sbjct: 165 DALTTGEALPQAVLKGHTAEGFGLCWNPNLPGNLATGAEDQVICLWDVQTQSFTSSETKV 224 Query: 247 --CVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFR----SQAHRDFV 300 + H+ V + F P LAS+S+DC+L + D+ L+ QAH + Sbjct: 225 ISPIAKYHRHTDIVNDVQFHPQHEALLASVSDDCTLQIHDTRLNPEEEAPKVIQAHSKAI 284 Query: 301 RDATWSPLNHSLLTTVGWDHQV 322 +P N LL T D V Sbjct: 285 NAVAINPFNDYLLATASADKTV 306 Score = 124 bits (312), Expect = 5e-29, Method: Composition-based stats. Identities = 43/224 (19%), Positives = 78/224 (34%), Gaps = 27/224 (12%) Query: 86 LTWVGE--RGILVASDSGAVELWE-----LDENETLIVSKFCKY-EHDDIVSTVSVLSSG 137 L W + ++ + LW+ +ET ++S KY H DIV+ V Sbjct: 188 LCWNPNLPGNLATGAEDQVICLWDVQTQSFTSSETKVISPIAKYHRHTDIVNDVQFHPQH 247 Query: 138 T-QAVSGSKDICIKVWDLA---QQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRIL 193 S S D +++ D ++ +AH+ + VA +P D + + S D + Sbjct: 248 EALLASVSDDCTLQIHDTRLNPEEEAPKVIQAHSKAINAVAINPFNDYLLATASADKTVA 307 Query: 194 LWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTK---------- 243 LWD R P L W P + + V + D + Sbjct: 308 LWDLRNPYQ-RLHTLEGHEDEVYGLEWSPHDEPILASSSTDRRVCIWDLEKIGEEQTPED 366 Query: 244 ----STSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVL 283 S + H+ ++ + P+ + SL++D L + Sbjct: 367 AEDGSPELLFMHGGHTNRISEFSWCPNERWVVGSLADDNILQIW 410 Score = 120 bits (300), Expect = 1e-27, Method: Composition-based stats. Identities = 38/234 (16%), Positives = 76/234 (32%), Gaps = 27/234 (11%) Query: 36 YRSDGALLLGASSLSGRCWAGS------LWLFKDPCAAPNEGFCSAGVQTEAG----VAD 85 + ++G L +L G G+ LW + +E + + V D Sbjct: 181 HTAEGFGLCWNPNLPGNLATGAEDQVICLWDVQTQSFTSSETKVISPIAKYHRHTDIVND 240 Query: 86 LTW--VGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAV-S 142 + + E + SD +++ + N K H ++ V++ + + Sbjct: 241 VQFHPQHEALLASVSDDCTLQIHDTRLNPEEEAPKVI-QAHSKAINAVAINPFNDYLLAT 299 Query: 143 GSKDICIKVWDLAQQVV-LSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRC-- 199 S D + +WDL L + H +V + SPH + + S S D R+ +WD Sbjct: 300 ASADKTVALWDLRNPYQRLHTLEGHEDEVYGLEWSPHDEPILASSSTDRRVCIWDLEKIG 359 Query: 200 ----------PKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTK 243 P + +W P + V ++ + + Sbjct: 360 EEQTPEDAEDGSPELLFMHGGHTNRISEFSWCPNERWVVGSLADDNILQIWSPS 413 Score = 67.5 bits (163), Expect = 7e-12, Method: Composition-based stats. Identities = 30/145 (20%), Positives = 49/145 (33%), Gaps = 22/145 (15%) Query: 211 PGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTK--------STSCVLSSAVHSQCVTGLV 262 + PQ+ E+ E G + DT H+ GL Sbjct: 130 HDGDVNRARYMPQKPEIIATMGEGGNAYIFDTTCHDALTTGEALPQAVLKGHTAEGFGLC 189 Query: 263 FSPHSVPFLASLSEDCSLAVLDSSL-----------SELFRSQAHRDFVRDATWSPLNHS 311 ++P+ LA+ +ED + + D S + + H D V D + P + + Sbjct: 190 WNPNLPGNLATGAEDQVICLWDVQTQSFTSSETKVISPIAKYHRHTDIVNDVQFHPQHEA 249 Query: 312 LLTTVGWDHQVVHHVV---PTEPLP 333 LL +V D + H P E P Sbjct: 250 LLASVSDDCTLQIHDTRLNPEEEAP 274 >5WLC-LU nrPDB Length = 489 Score = 143 bits (360), Expect = 1e-34, Method: Composition-based stats. Identities = 48/268 (17%), Positives = 100/268 (37%), Gaps = 26/268 (9%) Query: 71 GFCSAGVQTEAGVADLTWVGERGILVASDSGAVELWELDEN---ETLIVSKFCKYEHDDI 127 G C + DL + +L SD V+LW ++ + + + Sbjct: 115 GLCVTQPRFHDKKPDL--KSQNFMLSCSDDKTVKLWSINVDDYSNKNSSDNDSVTNEEGL 172 Query: 128 VST---------VSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPH 178 + T + + +G I +WD+ + +S A +T + + + Sbjct: 173 IRTFDGESAFQGIDSHRENSTFATGGA--KIHLWDVNRLKPVSDLSWGADNITSLKFNQN 230 Query: 179 KDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVS 238 + + S DN I+L+D R P +I ++ W+P ++ FV +E+ Sbjct: 231 ETDILASTGSDNSIVLYDLRTNSPTQKI---VQTMRTNAICWNPMEAFNFVTANEDHNAY 287 Query: 239 LVDTKSTSCVL-SSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSS---LSELFRSQ 294 D ++ S L H V + FSP + + S D S+ + ++ E++ ++ Sbjct: 288 YYDMRNLSRSLNVFKDHVSAVMDVDFSPTGDEIV-TGSYDKSIRIYKTNHGHSREIYHTK 346 Query: 295 AHRDFVRDATWSPLNHSLLTTVGWDHQV 322 + V +S ++ + + D V Sbjct: 347 RMQ-HVFQVKYS-MDSKYIISGSDDGNV 372 Score = 129 bits (325), Expect = 1e-30, Method: Composition-based stats. Identities = 44/229 (19%), Positives = 76/229 (33%), Gaps = 28/229 (12%) Query: 122 YEHDDIVSTVSVLSSG-TQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCV-----AA 175 Y H D V ++ + +GS D IK W+++ + S++AH VT + Sbjct: 64 YGHRDGVYAIAKNYGSLNKLATGSADGVIKYWNMSTREEFVSFKAHYGLVTGLCVTQPRF 123 Query: 176 SPHKDSV-----FLSCSEDNRILLWDTRCPK--------------PASQIGCSAPGYLPT 216 K + LSCS+D + LW I Sbjct: 124 HDKKPDLKSQNFMLSCSDDKTVKLWSINVDDYSNKNSSDNDSVTNEEGLIRTFDGESAFQ 183 Query: 217 SLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSE 276 + H +++ F G + L D V + + +T L F+ + LAS Sbjct: 184 GIDSH-RENSTFATGGA--KIHLWDVNRLKPVSDLSWGADNITSLKFNQNETDILASTGS 240 Query: 277 DCSLAVLDSSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQVVHH 325 D S+ + D + + W+P+ T DH ++ Sbjct: 241 DNSIVLYDLRTNSPTQKIVQTMRTNAICWNPMEAFNFVTANEDHNAYYY 289 Score = 73.6 bits (179), Expect = 1e-13, Method: Composition-based stats. Identities = 29/177 (16%), Positives = 62/177 (35%), Gaps = 22/177 (12%) Query: 83 VADLTWVGE------------RGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVST 130 V+DL+W + + ++ L++L N S K + Sbjct: 212 VSDLSWGADNITSLKFNQNETDILASTGSDNSIVLYDLRTN-----SPTQKIVQTMRTNA 266 Query: 131 VSVLSSGTQ-AVSGSKDICIKVWDLAQ-QVVLSSYRAHAAQVTCVAASPHKDSVFLSCSE 188 + V+ ++D +D+ L+ ++ H + V V SP D + ++ S Sbjct: 267 ICWNPMEAFNFVTANEDHNAYYYDMRNLSRSLNVFKDHVSAVMDVDFSPTGDEI-VTGSY 325 Query: 189 DNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKST 245 D I ++ T ++ + S+ + G ++G V L +K+ Sbjct: 326 DKSIRIYKTNHGHSREIYHTKRMQHVFQV--KYSMDSKYIISGSDDGNVRLWRSKAW 380 Score = 62.4 bits (150), Expect = 3e-10, Method: Composition-based stats. Identities = 24/128 (18%), Positives = 46/128 (35%), Gaps = 13/128 (10%) Query: 74 SAGVQTEAGVADLTWVGER--GILVASDSGAVELWELDE-NETLIVSKFCKYEHDDIVST 130 + + + W + A++ +++ + +L V K +H V Sbjct: 255 TQKIVQTMRTNAICWNPMEAFNFVTANEDHNAYYYDMRNLSRSLNVFK----DHVSAVMD 310 Query: 131 VSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQ---VTCVAASPHKDSVFLSCS 187 V +G + V+GS D I+++ Y H + V V S +S S Sbjct: 311 VDFSPTGDEIVTGSYDKSIRIYKTNHGHSREIY--HTKRMQHVFQVKYS-MDSKYIISGS 367 Query: 188 EDNRILLW 195 +D + LW Sbjct: 368 DDGNVRLW 375 >5WLC-LO nrPDB Length = 923 Score = 142 bits (359), Expect = 2e-34, Method: Composition-based stats. Identities = 43/213 (20%), Positives = 81/213 (38%), Gaps = 9/213 (4%) Query: 89 VGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDIC 148 GE +S G + ++E + + H D ++++ G++ V+ S+D Sbjct: 313 TGEWLAFGSSKLGQLLVYEWQSESYI----LKQQGHFDSTNSLAYSPDGSRVVTASEDGK 368 Query: 149 IKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGC 208 IKVWD+ L+++ H + VT V + V S S D + WD + Sbjct: 369 IKVWDITSGFCLATFEEHTSSVTAVQF-AKRGQVMFSSSLDGTVRAWDLIRYRNFRTF-T 426 Query: 209 SAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSV 268 LA P V +N + + ++ + + + H V+ L FS Sbjct: 427 GTERIQFNCLAVDPSGEVVCAGSLDNFDIHVWSVQTGQLLDALSGHEGPVSCLSFS-QEN 485 Query: 269 PFLASLSEDCSLAVLDS--SLSELFRSQAHRDF 299 LAS S D ++ + ++ + + D Sbjct: 486 SVLASASWDKTIRIWSIFGRSQQVEPIEVYSDV 518 Score = 106 bits (265), Expect = 1e-23, Method: Composition-based stats. Identities = 49/300 (16%), Positives = 95/300 (31%), Gaps = 73/300 (24%) Query: 91 ERGILVASDSGAVELWELDE---------------NETLIVSKFC--------KYEHDDI 127 + I S GAV +WE + E + +SK+ Y + Sbjct: 203 QEKIYTVSKDGAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQAK 262 Query: 128 VSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCS 187 V V+ + G +++DL ++ V V+ + + + S Sbjct: 263 VKCVTFHPATRLLAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVSVNQTGEWLAFGSS 322 Query: 188 EDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSC 247 + ++L+++ + + + SLA+ P S V V E+G + + D S C Sbjct: 323 KLGQLLVYEWQS--ESYILKQQGHFDSTNSLAYSPDGSRV-VTASEDGKIKVWDITSGFC 379 Query: 248 VLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRS-------------- 293 + + H+ VT + F+ + S S D ++ D FR+ Sbjct: 380 LATFEEHTSSVTAVQFAKRGQ-VMFSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAV 438 Query: 294 -------------------------------QAHRDFVRDATWSPLNHSLLTTVGWDHQV 322 H V ++S +S+L + WD + Sbjct: 439 DPSGEVVCAGSLDNFDIHVWSVQTGQLLDALSGHEGPVSCLSFS-QENSVLASASWDKTI 497 Score = 103 bits (257), Expect = 1e-22, Method: Composition-based stats. Identities = 34/272 (12%), Positives = 87/272 (31%), Gaps = 37/272 (13%) Query: 86 LTWVGERGILVASDSGAVELWELDENET-----LIVSKFCKYEHDDIVSTVSVLSSGTQA 140 + + + + + +++W+ + V H +++++ Sbjct: 102 VKFSPDGRLFALASGRFLQIWKTPDVNKDRQFAPFVRHRVHAGHFQDITSLTWSQDSRFI 161 Query: 141 VSGSKDICIKVWDLAQQVV---LSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDT 197 ++ SKD+ K+W + + +++ H V S ++ ++ + S+D + +W+ Sbjct: 162 LTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGAFFSHDQEKIY-TVSKDGAVFVWEF 220 Query: 198 RC----------------------PKPASQIGCS---APGYLPTSLAWHPQQSEVFVFGD 232 A + +HP + + G Sbjct: 221 TKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQAKVKCVTFHP-ATRLLAVGF 279 Query: 233 ENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSL-SELF 291 +G L D + + ++ V + + S+ L V + S + Sbjct: 280 TSGEFRLYDLPDFTLIQQLSMGQNPVNTVSVNQTGEWLAFGSSKLGQLLVYEWQSESYIL 339 Query: 292 RSQAHRDFVRDATWSPLNHSLLTTVGWDHQVV 323 + Q H D +SP + S + T D ++ Sbjct: 340 KQQGHFDSTNSLAYSP-DGSRVVTASEDGKIK 370 Score = 70.5 bits (171), Expect = 1e-12, Method: Composition-based stats. Identities = 36/215 (16%), Positives = 79/215 (36%), Gaps = 19/215 (8%) Query: 85 DLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGS 144 ++T+ + L++ V +++L N++ +YEH ++ + + GT +S Sbjct: 19 NITFSDDGKQLLSPVGNRVSVFDLINNKSF----TFEYEHRKNIAAIDLNKQGTLLISID 74 Query: 145 KDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLW---DTRCPK 201 +D + + + VL + + + V SP +F S + +W D + Sbjct: 75 EDGRAILVNFKARNVLHHFNF-KEKCSAVKFSPD-GRLFALAS-GRFLQIWKTPDVNKDR 131 Query: 202 PA----SQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTS---CVLSSAVH 254 + TSL W Q S + ++ + + S + H Sbjct: 132 QFAPFVRHRVHAGHFQDITSLTW-SQDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGH 190 Query: 255 SQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSE 289 V G FS + ++S+D ++ V + + Sbjct: 191 RDYVMGAFFSHDQEK-IYTVSKDGAVFVWEFTKRP 224 Score = 32.4 bits (72), Expect = 0.29, Method: Composition-based stats. Identities = 8/39 (20%), Positives = 18/39 (46%) Query: 125 DDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSY 163 +T+ G V+G + I ++D+ +V+L + Sbjct: 577 SKFFTTIHYSFDGMAIVAGGNNNSICLYDVPNEVLLKRF 615 >5I2T-A nrPDB Length = 742 Score = 142 bits (359), Expect = 2e-34, Method: Composition-based stats. Identities = 43/213 (20%), Positives = 81/213 (38%), Gaps = 9/213 (4%) Query: 89 VGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDIC 148 GE +S G + ++E + + H D ++++ G++ V+ S+D Sbjct: 338 TGEWLAFGSSKLGQLLVYEWQSESYI----LKQQGHFDSTNSLAYSPDGSRVVTASEDGK 393 Query: 149 IKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGC 208 IKVWD+ L+++ H + VT V + V S S D + WD + Sbjct: 394 IKVWDITSGFCLATFEEHTSSVTAVQF-AKRGQVMFSSSLDGTVRAWDLIRYRNFRTF-T 451 Query: 209 SAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSV 268 LA P V +N + + ++ + + + H V+ L FS Sbjct: 452 GTERIQFNCLAVDPSGEVVCAGSLDNFDIHVWSVQTGQLLDALSGHEGPVSCLSFS-QEN 510 Query: 269 PFLASLSEDCSLAVLDS--SLSELFRSQAHRDF 299 LAS S D ++ + ++ + + D Sbjct: 511 SVLASASWDKTIRIWSIFGRSQQVEPIEVYSDV 543 Score = 106 bits (265), Expect = 1e-23, Method: Composition-based stats. Identities = 49/300 (16%), Positives = 95/300 (31%), Gaps = 73/300 (24%) Query: 91 ERGILVASDSGAVELWELDE---------------NETLIVSKFC--------KYEHDDI 127 + I S GAV +WE + E + +SK+ Y + Sbjct: 228 QEKIYTVSKDGAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQAK 287 Query: 128 VSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCS 187 V V+ + G +++DL ++ V V+ + + + S Sbjct: 288 VKCVTFHPATRLLAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVSVNQTGEWLAFGSS 347 Query: 188 EDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSC 247 + ++L+++ + + + SLA+ P S V V E+G + + D S C Sbjct: 348 KLGQLLVYEWQS--ESYILKQQGHFDSTNSLAYSPDGSRV-VTASEDGKIKVWDITSGFC 404 Query: 248 VLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRS-------------- 293 + + H+ VT + F+ + S S D ++ D FR+ Sbjct: 405 LATFEEHTSSVTAVQFAKRGQ-VMFSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAV 463 Query: 294 -------------------------------QAHRDFVRDATWSPLNHSLLTTVGWDHQV 322 H V ++S +S+L + WD + Sbjct: 464 DPSGEVVCAGSLDNFDIHVWSVQTGQLLDALSGHEGPVSCLSFS-QENSVLASASWDKTI 522 Score = 103 bits (257), Expect = 1e-22, Method: Composition-based stats. Identities = 34/272 (12%), Positives = 87/272 (31%), Gaps = 37/272 (13%) Query: 86 LTWVGERGILVASDSGAVELWELDENET-----LIVSKFCKYEHDDIVSTVSVLSSGTQA 140 + + + + + +++W+ + V H +++++ Sbjct: 127 VKFSPDGRLFALASGRFLQIWKTPDVNKDRQFAPFVRHRVHAGHFQDITSLTWSQDSRFI 186 Query: 141 VSGSKDICIKVWDLAQQVV---LSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDT 197 ++ SKD+ K+W + + +++ H V S ++ ++ + S+D + +W+ Sbjct: 187 LTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGAFFSHDQEKIY-TVSKDGAVFVWEF 245 Query: 198 RC----------------------PKPASQIGCS---APGYLPTSLAWHPQQSEVFVFGD 232 A + +HP + + G Sbjct: 246 TKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQAKVKCVTFHP-ATRLLAVGF 304 Query: 233 ENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSL-SELF 291 +G L D + + ++ V + + S+ L V + S + Sbjct: 305 TSGEFRLYDLPDFTLIQQLSMGQNPVNTVSVNQTGEWLAFGSSKLGQLLVYEWQSESYIL 364 Query: 292 RSQAHRDFVRDATWSPLNHSLLTTVGWDHQVV 323 + Q H D +SP + S + T D ++ Sbjct: 365 KQQGHFDSTNSLAYSP-DGSRVVTASEDGKIK 395 Score = 70.5 bits (171), Expect = 1e-12, Method: Composition-based stats. Identities = 36/215 (16%), Positives = 79/215 (36%), Gaps = 19/215 (8%) Query: 85 DLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGS 144 ++T+ + L++ V +++L N++ +YEH ++ + + GT +S Sbjct: 44 NITFSDDGKQLLSPVGNRVSVFDLINNKSF----TFEYEHRKNIAAIDLNKQGTLLISID 99 Query: 145 KDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLW---DTRCPK 201 +D + + + VL + + + V SP +F S + +W D + Sbjct: 100 EDGRAILVNFKARNVLHHFNF-KEKCSAVKFSPD-GRLFALAS-GRFLQIWKTPDVNKDR 156 Query: 202 PA----SQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTS---CVLSSAVH 254 + TSL W Q S + ++ + + S + H Sbjct: 157 QFAPFVRHRVHAGHFQDITSLTW-SQDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGH 215 Query: 255 SQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSE 289 V G FS + ++S+D ++ V + + Sbjct: 216 RDYVMGAFFSHDQEK-IYTVSKDGAVFVWEFTKRP 249 Score = 32.4 bits (72), Expect = 0.29, Method: Composition-based stats. Identities = 8/39 (20%), Positives = 18/39 (46%) Query: 125 DDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSY 163 +T+ G V+G + I ++D+ +V+L + Sbjct: 602 SKFFTTIHYSFDGMAIVAGGNNNSICLYDVPNEVLLKRF 640 >5WYJ-BE nrPDB Length = 939 Score = 142 bits (357), Expect = 3e-34, Method: Composition-based stats. Identities = 42/226 (18%), Positives = 86/226 (38%), Gaps = 10/226 (4%) Query: 92 RGILVASDSGAV-ELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIK 150 I+ A W++ + D V +V++ G GS + I Sbjct: 428 ENIITAHKDEKFARTWDMR--NKRVGRWTFDTTDDGFVKSVAMSQCGNFGFIGSSNGSIT 485 Query: 151 VWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSA 210 ++++ ++ Y+ H VT ++ + +SC D + +D ++ A Sbjct: 486 IYNMQSGILRKKYKLHKRAVTGISLDGMNRKM-VSCGLDGIVGFYDFNKSTLLGKLKLDA 544 Query: 211 PGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPF 270 P T++ +H + S++F ++ ++ ++D + V HS +T FSP + Sbjct: 545 P---ITAMVYH-RSSDLFALALDDLSIVVIDAVTQRVVRQLWGHSNRITAFDFSPEG-RW 599 Query: 271 LASLSEDCSLAVLDSSLSELFRSQAHRDFVRDATWSPLNHSLLTTV 316 + S S D ++ D + + +SP N LL T Sbjct: 600 IVSASLDSTIRTWDLPTGGCIDGIIVDNVATNVKFSP-NGDLLATT 644 Score = 60.9 bits (146), Expect = 7e-10, Method: Composition-based stats. Identities = 41/296 (13%), Positives = 96/296 (32%), Gaps = 41/296 (13%) Query: 69 NEGFCSAGVQT-EAGVADLTWVGE--RGILVASDSGAVELWELDENETLIVSKFCKYEHD 125 +G ++ ++ ++ L++ + + V + SG + ++LD + V K E Sbjct: 236 RKGKRIRTIKIPQSRISSLSFRTDGSSHLSVGTSSGDLIFYDLDRRSRIHVLKNIHRESY 295 Query: 126 DIVSTVSVLSSGTQAVSGSKDICIK--VWD-----------LAQQVVLSSYRAHAAQVTC 172 V+ + L+ V+ D +K V+D + L S H+ + Sbjct: 296 GGVTQATFLNGQPIIVTSGGDNSLKEYVFDPSLSQGSGDVVVQPPRYLRSRGGHSQPPSY 355 Query: 173 VAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYL--------------PTSL 218 +A + + LS S+D + + R + ++ P + Sbjct: 356 IAFADSQSHFMLSASKDRSLWSFSLRKDAQSQEMSQRLHKKQDGGRVGGSTIKSKFPEIV 415 Query: 219 AWHPQQS-----EVFVFGDENGTV-SLVDTKSTSC--VLSSAVHSQCVTGLVFSPHSVPF 270 A + + E + ++ D ++ V + S Sbjct: 416 ALAIENARIGEWENIITAHKDEKFARTWDMRNKRVGRWTFDTTDDGFVKSVAMSQCGNFG 475 Query: 271 LASLSEDCSLAVLDSSLSELFRS-QAHRDFVRDATWSPLNHSLLTTVGWDHQVVHH 325 S + S+ + + L + + H+ V + +N + + G D V + Sbjct: 476 FI-GSSNGSITIYNMQSGILRKKYKLHKRAVTGISLDGMNR-KMVSCGLDGIVGFY 529 Score = 49.4 bits (116), Expect = 2e-06, Method: Composition-based stats. Identities = 28/219 (12%), Positives = 71/219 (32%), Gaps = 20/219 (9%) Query: 93 GILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVW 152 L V L+ + + + S E D ++T G+ + ++ Sbjct: 178 NKLTVVTKSNVLLFNVRTGKLVFTSN----EFPDQITTAEPAPVLDIIALGTVTGEVIMF 233 Query: 153 DLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGC-SAP 211 ++ + + + + ++++ ++ S + ++ +D + Sbjct: 234 NMRKGKRIRTIKIPQSRISSLSFRTDGSSHLSVGTSSGDLIFYDLDRRSRIHVLKNIHRE 293 Query: 212 GYLPTSLAWHPQQSEVFVFGDENGTVS--LVDT-----------KSTSCVLSSAVHSQCV 258 Y + A + V + ++ + D + + S HSQ Sbjct: 294 SYGGVTQATFLNGQPIIVTSGGDNSLKEYVFDPSLSQGSGDVVVQPPRYLRSRGGHSQPP 353 Query: 259 TGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHR 297 + + F+ F+ S S+D S + SL + +SQ Sbjct: 354 SYIAFADSQSHFMLSASKDRS--LWSFSLRKDAQSQEMS 390 >4V7E-Bg nrPDB Length = 380 Score = 141 bits (356), Expect = 3e-34, Method: Composition-based stats. Identities = 48/234 (20%), Positives = 87/234 (37%), Gaps = 18/234 (7%) Query: 68 PNEGFCSAGVQTEAG-VADLTWVGERG-ILVASDSGAVELWELDENETLIVSKFCKYEHD 125 P + C +Q +G V L W E+ I+ AS G + +W ++ K H Sbjct: 53 PTDLVCCRTLQGHSGKVYSLDWTPEKNWIVSASQDGRLIVWNALTSQKTHAIKL----HC 108 Query: 126 DIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQV-------VLSSYRAHAAQVTCVAASPH 178 V + +G G D +++L+ Q V H + P Sbjct: 109 PWVMECAFAPNGQSVACGGLDSACSIFNLSSQADRDGNMPVSRVLTGHKGYASSCQYVPD 168 Query: 179 KDSVFLSCSEDNRILLWDTRCPKPASQIGC---SAPGYLPTSLAWHPQQSEVFVFGDENG 235 +++ ++ S D +LWD + S G S SL+ + + +F+ G + Sbjct: 169 QETRLITGSGDQTCVLWDVTTGQRISIFGSEFPSGHTADVLSLSINSLNANMFISGSCDT 228 Query: 236 TVSLVDTK-STSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLS 288 TV L D + ++ V + H + + F P F + S+D + + D Sbjct: 229 TVRLWDLRITSRAVRTYHGHEGDINSVKFFPDGQRF-GTGSDDGTCRLFDMRTG 281 Score = 116 bits (290), Expect = 1e-26, Method: Composition-based stats. Identities = 37/224 (16%), Positives = 70/224 (31%), Gaps = 14/224 (6%) Query: 111 NETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQV 170 N T +V H V ++ VS S+D + VW+ + + H V Sbjct: 52 NPTDLVCCRTLQGHSGKVYSLDWTPEKNWIVSASQDGRLIVWNALTSQKTHAIKLHCPWV 111 Query: 171 TCVAASPHKDSVFLSCSEDNRILLWDT-----RCPKPASQIGCSAPGYLPTSLAWHPQQS 225 A +P+ SV D+ +++ R + +S + P Q Sbjct: 112 MECAFAPNGQSV-ACGGLDSACSIFNLSSQADRDGNMPVSRVLTGHKGYASSCQYVPDQE 170 Query: 226 EVFVFGDENGTVSLVDTKSTSCVLSS-----AVHSQCVTGLVFSPHSVPFLASLSEDCSL 280 + G + T L D + + + H+ V L + + S S D ++ Sbjct: 171 TRLITGSGDQTCVLWDVTTGQRISIFGSEFPSGHTADVLSLSINSLNANMFISGSCDTTV 230 Query: 281 AVLDSSL--SELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQV 322 + D + + H + + P + T D Sbjct: 231 RLWDLRITSRAVRTYHGHEGDINSVKFFP-DGQRFGTGSDDGTC 273 Score = 81.7 bits (200), Expect = 4e-16, Method: Composition-based stats. Identities = 28/178 (15%), Positives = 55/178 (30%), Gaps = 21/178 (11%) Query: 89 VGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDIC 148 + + S V LW+L + + H+ +++V G + +GS D Sbjct: 216 LNANMFISGSCDTTVRLWDLRITSRAV---RTYHGHEGDINSVKFFPDGQRFGTGSDDGT 272 Query: 149 IKVWDLAQQVVLSSYRAHAAQ-------VTCVAASPHKDSVFLSCSEDNRILLWDTRCPK 201 +++D+ L Y + VT VA S +F + +WDT + Sbjct: 273 CRLFDMRTGHQLQVYNREPDRNDNELPIVTSVAFSISGRLLFA-GYSNGDCYVWDTLLAE 331 Query: 202 PASQIG-CSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCV 258 +G S G + + + + + H + V Sbjct: 332 MVLNLGTLQNSHEGRISCLGLSSDGSALCTGSWDKNLKIW---------AFSGHRKIV 380 Score = 50.9 bits (120), Expect = 7e-07, Method: Composition-based stats. Identities = 18/100 (18%), Positives = 38/100 (38%), Gaps = 3/100 (3%) Query: 232 DENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLD-SSLSEL 290 + T + C + HS V L ++P ++ S S+D L V + + + Sbjct: 43 AQGRTAVSFNPTDLVCCRTLQGHSGKVYSLDWTP-EKNWIVSASQDGRLIVWNALTSQKT 101 Query: 291 FRSQAHRDFVRDATWSPLNHSLLTTVGWDHQVVHHVVPTE 330 + H +V + ++P N + G D + ++ Sbjct: 102 HAIKLHCPWVMECAFAP-NGQSVACGGLDSACSIFNLSSQ 140 >6J6H-n nrPDB Length = 455 Score = 141 bits (354), Expect = 5e-34, Method: Composition-based stats. Identities = 40/214 (18%), Positives = 82/214 (38%), Gaps = 17/214 (7%) Query: 123 EHDDIVSTVSVLS-SGTQAVSGSKDICIKVWDLAQQ-VVLSSYRAHAAQVTCVAASPHKD 180 H + + + L +G +SG D IK+WD L ++ H + + + Sbjct: 160 GHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQ 219 Query: 181 SVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLV 240 S FLS S D + +WDT K +++ P + P F+ G N + Sbjct: 220 S-FLSSSFDRSVKIWDTETGKVKTRLHL---NSTPADVESRPTNPHEFIVGLSNSKILHY 275 Query: 241 DTK---STSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSS----LSELFRS 293 D + + V + H + L + P F++S SED ++ + ++ + ++ + Sbjct: 276 DDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISS-SEDKTVRIWENQINVPIKQISDT 334 Query: 294 QAHRDFVRDATWSPLNHSLLTTVGWDHQVVHHVV 327 H + P + + D+++ + Sbjct: 335 AQHSMPFLNV--HP-SQNYFCAQSMDNRIYSFSL 365 Score = 103 bits (257), Expect = 1e-22, Method: Composition-based stats. Identities = 47/286 (16%), Positives = 85/286 (29%), Gaps = 63/286 (22%) Query: 92 RGILVASDSGAVELWEL-DENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIK 150 IL + +++W+ + E L + H+ + + +S S D +K Sbjct: 176 HLILSGGNDHTIKIWDFYHDYECLRDFQ----GHNKPIKALRFTEDCQSFLSSSFDRSVK 231 Query: 151 VWDLAQQV---------------------------------------------VLSSYRA 165 +WD ++ +Y Sbjct: 232 IWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDH 291 Query: 166 HAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQS 225 H + + + P S F+S SED + +W+ + P QI +A +P L HP Q+ Sbjct: 292 HLSSILALKYFPD-GSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPF-LNVHPSQN 349 Query: 226 EVFVFGDENGTVSLVDTK---STSCVLSSAVHSQCVTGL--VFSPHSVPFLASLSEDCSL 280 F + + K HS G+ FS ++ S L Sbjct: 350 Y-FCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDG-RYICSGDSKSRL 407 Query: 281 AVLDSSLSELF---RSQAHRDFVRDATWSPLNHSLLTTVGWDHQVV 323 D + S L + + W P S + G ++ Sbjct: 408 FTWDWNTSRLLNNIKIPG-NKPITQVDWHPQETSKVICSGAAGKIY 452 Score = 65.1 bits (157), Expect = 5e-11, Method: Composition-based stats. Identities = 35/196 (17%), Positives = 71/196 (36%), Gaps = 15/196 (7%) Query: 54 WAGSLWLFKDPCAAPNEGFCSAGVQTEAGVADLTWVGE-RGILVASDSGAVELWELDENE 112 + S L D + N+G + + L + + + +S+ V +W EN+ Sbjct: 267 LSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIW---ENQ 323 Query: 113 TLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLA---QQVVLSSYRAHAAQ 169 + K + ++V S + S D I + L ++ ++ H++ Sbjct: 324 INVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSA 383 Query: 170 VT--CVAASPHKDSVFLSCSEDNRILL--WDTRCPKPASQIGCSAPGYLPTSLAWHPQQS 225 +A S + CS D++ L WD + + I T + WHPQ++ Sbjct: 384 GYGISLAFSGDGRYI---CSGDSKSRLFTWDWNTSRLLNNIKIPG-NKPITQVDWHPQET 439 Query: 226 EVFVFGDENGTVSLVD 241 + G + + D Sbjct: 440 SKVICSGAAGKIYVCD 455 >3JAP-g nrPDB Length = 326 Score = 141 bits (354), Expect = 6e-34, Method: Composition-based stats. Identities = 50/226 (22%), Positives = 79/226 (34%), Gaps = 11/226 (4%) Query: 91 ERGILVASDSGAVELWELDENETLIVSKFCKY-EHDDIVSTVSVLSSGTQAVSGSKDICI 149 ++ S + W L ENE Y H IV V V + G AVS S D + Sbjct: 31 PNLLVSGSRDKTLISWRLTENEQQFGVPVRSYKGHSHIVQDVVVSADGNYAVSASWDKTL 90 Query: 150 KVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCS 209 ++W+LA + + H V VA + + +S S D I +W+T +G + Sbjct: 91 RLWNLATGNSEARFVGHTGDVLSVAIDANSSKI-ISASRDKTIRVWNTVGDCAYVLLGHT 149 Query: 210 APGYLPTSLAWHPQQSEV------FVFGDENGTVSLVDTK--STSCVLSSAVHSQCVTGL 261 + + EV FV + V S H+ + + Sbjct: 150 DWVTKVRVAPKNLEDGEVDDGRITFVSAGMDKIVRSWSLNEDSYRIEADFIGHNNYINVV 209 Query: 262 VFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHRDFVRDATWSP 307 SP AS +D + V + F + +D V +SP Sbjct: 210 QPSPDG-SLAASAGKDGQIYVWNLKHKSAFMNFDAKDEVFALAFSP 254 Score = 112 bits (280), Expect = 2e-25, Method: Composition-based stats. Identities = 43/234 (18%), Positives = 83/234 (35%), Gaps = 24/234 (10%) Query: 108 LDENETLIVSKFCKYEHDDIVSTVSVLSSG-TQAVSGSKDICIKVWDL-----AQQVVLS 161 + + ++V + H+ V+++S ++ VSGS+D + W L V + Sbjct: 1 MSSSNIMLVLRGTLEGHNGWVTSLSTSAAQPNLLVSGSRDKTLISWRLTENEQQFGVPVR 60 Query: 162 SYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWH 221 SY+ H+ V V S + +S S D + LW+ ++ L ++ Sbjct: 61 SYKGHSHIVQDVVVSAD-GNYAVSASWDKTLRLWNLATGNSEARFVGHTGDVLSVAID-- 117 Query: 222 PQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSP---------HSVPFLA 272 S + + T+ + +T C H+ VT + +P Sbjct: 118 -ANSSKIISASRDKTIRVWNTV-GDCAYVLLGHTDWVTKVRVAPKNLEDGEVDDGRITFV 175 Query: 273 SLSEDCSLAVL---DSSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQVV 323 S D + + S H +++ SP + SL + G D Q+ Sbjct: 176 SAGMDKIVRSWSLNEDSYRIEADFIGHNNYINVVQPSP-DGSLAASAGKDGQIY 228 Score = 84.4 bits (207), Expect = 6e-17, Method: Composition-based stats. Identities = 34/214 (15%), Positives = 68/214 (31%), Gaps = 32/214 (14%) Query: 90 GERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQ---------- 139 I+ AS + +W T+ + H D V+ V V + Sbjct: 119 NSSKIISASRDKTIRVWN-----TVGDCAYVLLGHTDWVTKVRVAPKNLEDGEVDDGRIT 173 Query: 140 AVSGSKDICIKVWDLA--QQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDT 197 VS D ++ W L + + + H + V SP S+ S +D +I +W+ Sbjct: 174 FVSAGMDKIVRSWSLNEDSYRIEADFIGHNNYINVVQPSPD-GSLAASAGKDGQIYVWNL 232 Query: 198 RCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSA----V 253 + + +LA+ P S ++ + + D ++ + Sbjct: 233 KHKSAFMNFDAKDEVF---ALAFSP--SRFWLTAATASGIKIYDLENEVLIDELKPEFAG 287 Query: 254 HSQC----VTGLVFSPHSVPFLASLSEDCSLAVL 283 +++ L +S A D + V Sbjct: 288 YTKAQDPHAVSLAWSADGQTLFA-GYTDNVIRVW 320 Score = 32.4 bits (72), Expect = 0.30, Method: Composition-based stats. Identities = 19/80 (23%), Positives = 37/80 (46%), Gaps = 8/80 (10%) Query: 83 VADLTWVGERGILVASDSGAVELWELDENETLI------VSKFCKYEHDDIVSTVSVLSS 136 V L + R L A+ + +++++L ENE LI + + K + V +++ + Sbjct: 247 VFALAFSPSRFWLTAATASGIKIYDL-ENEVLIDELKPEFAGYTKAQDPHAV-SLAWSAD 304 Query: 137 GTQAVSGSKDICIKVWDLAQ 156 G +G D I+VW + Sbjct: 305 GQTLFAGYTDNVIRVWQVMT 324 >3JB9-g nrPDB Length = 558 Score = 141 bits (354), Expect = 6e-34, Method: Composition-based stats. Identities = 41/167 (24%), Positives = 71/167 (42%), Gaps = 9/167 (5%) Query: 123 EHDDIVSTVSVLS-SGTQAVSGSKDICIKVWDLAQQV-VLSSYRAHAAQVTCVAASPHKD 180 H +S + SG +SGS D IK+W++ +L +++ HA + ++ S Sbjct: 264 GHTKGISCLRFFPISGHLLLSGSMDNQIKIWEVYHDRSLLRTFQGHARPIRDLSFSQDGR 323 Query: 181 SVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWH--PQQSEVFVFGDENGTVS 238 S FLS S D I LWDT K + C L + + P + F+ G + + Sbjct: 324 S-FLSTSFDKTIKLWDTELGKC---LNCFNSDRLTNCVKFQVDPDKPNEFLAGTADKRIL 379 Query: 239 LVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDS 285 D +S V + H + + F + F+ + S+D S+ + Sbjct: 380 QFDIRSPDIVQAYDHHLGGINSITFLENGKRFV-TTSDDSSMRFWEY 425 Score = 116 bits (291), Expect = 1e-26, Method: Composition-based stats. Identities = 47/290 (16%), Positives = 98/290 (33%), Gaps = 22/290 (7%) Query: 49 LSGRCW-AGSLWLFKDPCAAPNEGFCSAGVQTEAG-VADLTWVGE-RGILVASDSGAVEL 105 +SG +GS+ ++ Q A + DL++ + R L S ++L Sbjct: 277 ISGHLLLSGSMDNQIKIWEVYHDRSLLRTFQGHARPIRDLSFSQDGRSFLSTSFDKTIKL 336 Query: 106 WELDENETLIVSKFCKYEHDDIVSTVSV--LSSGTQ-AVSGSKDICIKVWDLAQQVVLSS 162 W+ + + L + + + V ++G+ D I +D+ ++ + Sbjct: 337 WDTELGKCLNCFNSDR-----LTNCVKFQVDPDKPNEFLAGTADKRILQFDIRSPDIVQA 391 Query: 163 YRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHP 222 Y H + + F++ S+D+ + W+ P P + A +P +A P Sbjct: 392 YDHHLGGINSITF-LENGKRFVTTSDDSSMRFWEYGTPVPIKFVADIAMHSMP-RVALRP 449 Query: 223 QQSEVFVFGDENGTVSLVDT-----KSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSED 277 + + + ++ V S + FSP F+ S Sbjct: 450 NGKS-IACQSLDNCIYVYSAYEKYRQNKKKVFKGYSCSGYSLEVGFSPDG-RFVFSGDSS 507 Query: 278 CSLAVLDSSLSELF-RSQAHRDFVRDATWSPLNHSLLTTVG-WDHQVVHH 325 + D +L + AH V+ + P S + T D + + Sbjct: 508 GNACFWDWKTCKLMAKLPAHSGPVQSMAFHPQETSKVATSSIVDGSIKYW 557 Score = 71.3 bits (173), Expect = 6e-13, Method: Composition-based stats. Identities = 21/101 (20%), Positives = 31/101 (30%), Gaps = 2/101 (1%) Query: 98 SDSGAVELWELDEN-ETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQ 156 S + ++ E F Y V G SG WD Sbjct: 458 SLDNCIYVYSAYEKYRQNKKKVFKGYSCSGYSLEVGFSPDGRFVFSGDSSGNACFWDWKT 517 Query: 157 QVVLSSYRAHAAQVTCVAASPHKDSVFLSCS-EDNRILLWD 196 +++ AH+ V +A P + S + S D I WD Sbjct: 518 CKLMAKLPAHSGPVQSMAFHPQETSKVATSSIVDGSIKYWD 558 Score = 59.0 bits (141), Expect = 3e-09, Method: Composition-based stats. Identities = 19/80 (23%), Positives = 34/80 (42%), Gaps = 7/80 (8%) Query: 248 VLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVL----DSSLSELFRSQAHRDFVRDA 303 + + H++ ++ L F P S L S S D + + D SL F Q H +RD Sbjct: 259 IFTWKGHTKGISCLRFFPISGHLLLSGSMDNQIKIWEVYHDRSLLRTF--QGHARPIRDL 316 Query: 304 TWSPLNHSLLTTVGWDHQVV 323 ++S + + +D + Sbjct: 317 SFS-QDGRSFLSTSFDKTIK 335 Score = 29.3 bits (64), Expect = 2.7, Method: Composition-based stats. Identities = 7/36 (19%), Positives = 16/36 (44%) Query: 288 SELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQVV 323 +F + H + + P++ LL + D+Q+ Sbjct: 257 KHIFTWKGHTKGISCLRFFPISGHLLLSGSMDNQIK 292 >5GAN-H nrPDB Length = 465 Score = 135 bits (339), Expect = 3e-32, Method: Composition-based stats. Identities = 54/276 (19%), Positives = 98/276 (35%), Gaps = 14/276 (5%) Query: 54 WAGSLWLFKDPCAAPNEGFCSAGVQTEAGVADLTWVGERG--ILVASDSGAVELWELDEN 111 WAG L + P + V + + W + ++ ++ G ++ ++ Sbjct: 195 WAGDLQVLNSQTLQPLTQKLDSHV---GKIGAIDWHPDSNNQMISCAEDGLIKNFQYSNE 251 Query: 112 ETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVT 171 E + H+ +S V SG S S D+ ++WD + L H V Sbjct: 252 EGGLRLLGDLVGHERRISDVKYHPSGKFIGSASHDMTWRLWDASTHQELLLQEGHDKGVF 311 Query: 172 CVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFG 231 ++ S+ S D+ +LWD R + + ++AW P +V G Sbjct: 312 SLSF-QCDGSLVCSGGMDSLSMLWDIRSGS--KVMTLAGHSKPIYTVAWSPNGYQV-ATG 367 Query: 232 DENGTVSLVDTKSTSC--VLSSAVHSQCVTGLVFSP-HSVPFLASLSEDCSLAVLDS-SL 287 +G +++ D + + H VT + FS L S D + V S + Sbjct: 368 GGDGIINVWDIRKRDEGQLNQILAHRNIVTQVRFSKEDGGKKLVSCGYDNLINVYSSDTW 427 Query: 288 SELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQVV 323 ++ H D + S N L + GWD + Sbjct: 428 LKMGSLAGHTDKIISLDIS-NNSHFLVSGGWDRSIK 462 Score = 129 bits (323), Expect = 2e-30, Method: Composition-based stats. Identities = 42/212 (19%), Positives = 84/212 (39%), Gaps = 8/212 (3%) Query: 75 AGVQTEAGVADLTWVGE-RGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSV 133 V E ++D+ + + I AS LW+ ++ L++ + HD V ++S Sbjct: 260 DLVGHERRISDVKYHPSGKFIGSASHDMTWRLWDASTHQELLLQE----GHDKGVFSLSF 315 Query: 134 LSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRIL 193 G+ SG D +WD+ + + H+ + VA SP+ + D I Sbjct: 316 QCDGSLVCSGGMDSLSMLWDIRSGSKVMTLAGHSKPIYTVAWSPN-GYQVATGGGDGIIN 374 Query: 194 LWDTRCPKPASQIGCSAPGYLPTSLAWHPQQ-SEVFVFGDENGTVSLVDTKSTSCVLSSA 252 +WD R A + T + + + + V + +++ + + + S A Sbjct: 375 VWDIRKRDEGQLNQILAHRNIVTQVRFSKEDGGKKLVSCGYDNLINVYSSDTWLKMGSLA 434 Query: 253 VHSQCVTGLVFSPHSVPFLASLSEDCSLAVLD 284 H+ + L S ++ FL S D S+ + + Sbjct: 435 GHTDKIISLDIS-NNSHFLVSGGWDRSIKLWN 465 Score = 35.5 bits (80), Expect = 0.037, Method: Composition-based stats. Identities = 12/78 (15%), Positives = 32/78 (41%), Gaps = 3/78 (3%) Query: 255 SQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSE--LFRSQAHRDFVRDATWSPLNHSL 312 ++ ++ + S + +A+ S L VL+S + + +H + W P +++ Sbjct: 175 TKPISAVSLSTDDM-VVATGSWAGDLQVLNSQTLQPLTQKLDSHVGKIGAIDWHPDSNNQ 233 Query: 313 LTTVGWDHQVVHHVVPTE 330 + + D + + E Sbjct: 234 MISCAEDGLIKNFQYSNE 251 >5UZ7-B nrPDB Length = 351 Score = 134 bits (337), Expect = 5e-32, Method: Composition-based stats. Identities = 46/245 (18%), Positives = 86/245 (35%), Gaps = 16/245 (6%) Query: 81 AGVADLTWVGERGILV-ASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQ 139 A + + W + +LV AS G + +W+ + V T + SG Sbjct: 67 AKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLR----SSWVMTCAYAPSGNY 122 Query: 140 AVSGSKDICIKVWDLAQQ----VVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLW 195 G D +++L + V H ++C ++ S D LW Sbjct: 123 VACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQ--IVTSSGDTTCALW 180 Query: 196 DTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHS 255 D + + + SLA + +FV G + + L D + C + H Sbjct: 181 DIETGQQTTTFTGHTGDVMSLSLA---PDTRLFVSGACDASAKLWDVREGMCRQTFTGHE 237 Query: 256 QCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHRDFVRDATWSPLNHS-LLT 314 + + F P+ F A+ S+D + + D + + +H + + T + S L Sbjct: 238 SDINAICFFPNGNAF-ATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLL 296 Query: 315 TVGWD 319 G+D Sbjct: 297 LAGYD 301 Score = 125 bits (314), Expect = 3e-29, Method: Composition-based stats. Identities = 34/197 (17%), Positives = 79/197 (40%), Gaps = 7/197 (3%) Query: 88 WVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDI 147 ++ + I+ +S LW+++ H V ++S+ VSG+ D Sbjct: 162 FLDDNQIVTSSGDTTCALWDIE----TGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDA 217 Query: 148 CIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIG 207 K+WD+ + + ++ H + + + P+ ++ F + S+D L+D R + Sbjct: 218 SAKLWDVREGMCRQTFTGHESDINAICFFPNGNA-FATGSDDATCRLFDLRADQELMTYS 276 Query: 208 CSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHS 267 TS+++ + + + G ++ ++ D A H V+ L + Sbjct: 277 HDNIICGITSVSF-SKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDG 335 Query: 268 VPFLASLSEDCSLAVLD 284 + +A+ S D L + + Sbjct: 336 MA-VATGSWDSFLKIWN 351 Score = 99.8 bits (247), Expect = 2e-21, Method: Composition-based stats. Identities = 31/207 (14%), Positives = 66/207 (31%), Gaps = 4/207 (1%) Query: 117 SKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAAS 176 ++ H + + + VS S+D + +WD + + ++ V A + Sbjct: 58 TRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYA 117 Query: 177 PHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGT 236 P + V DN +++ + + ++ G+ V + T Sbjct: 118 PSGNYV-ACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTT 176 Query: 237 VSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSEL-FRSQA 295 +L D ++ + H+ V L +P + S + D S + D Sbjct: 177 CALWDIETGQQTTTFTGHTGDVMSLSLAPDT-RLFVSGACDASAKLWDVREGMCRQTFTG 235 Query: 296 HRDFVRDATWSPLNHSLLTTVGWDHQV 322 H + + P N + T D Sbjct: 236 HESDINAICFFP-NGNAFATGSDDATC 261 Score = 52.0 bits (123), Expect = 3e-07, Method: Composition-based stats. Identities = 17/73 (23%), Positives = 32/73 (43%), Gaps = 5/73 (6%) Query: 82 GVADLTWVGE-RGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQA 140 G+ +++ R +L D +W+ + + V HD+ VS + V G Sbjct: 283 GITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGV----LAGHDNRVSCLGVTDDGMAV 338 Query: 141 VSGSKDICIKVWD 153 +GS D +K+W+ Sbjct: 339 ATGSWDSFLKIWN 351 >5WYJ-BC nrPDB Length = 817 Score = 131 bits (330), Expect = 3e-31, Method: Composition-based stats. Identities = 43/243 (17%), Positives = 85/243 (34%), Gaps = 22/243 (9%) Query: 94 ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSV-----LSSGTQAVSGSKDIC 148 I AS +W +EN H V+ V + ++ S D+ Sbjct: 403 IATASKDNTAIVWRYNENSCKFDIYAKYIGHSAAVTAVGLPNIVSKGYPEFLLTASNDLT 462 Query: 149 IKVW---------DLA-QQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTR 198 IK W D+ +V + AH + ++ SP+ DS+F + S D +W+ Sbjct: 463 IKKWIIPKPTASMDVQIIKVSEYTRHAHEKDINALSVSPN-DSIFATASYDKTCKIWNLE 521 Query: 199 CPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCV 258 + + + G S Q ++ + TV + + S + + H+ V Sbjct: 522 NGELEATLANHKRGLWDVSFC---QYDKLLATSSGDKTVKIWSLDTFSVMKTLEGHTNAV 578 Query: 259 TGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRS-QAHRDFVRDATWSPLNHSLLTTVG 317 F + L S D + + D S E ++ H + + + + + ++ + Sbjct: 579 QRCSFI-NKQKQLISCGADGLIKIWDCSSGECLKTLDGHNNRLWALS-TMNDGDMIVSAD 636 Query: 318 WDH 320 D Sbjct: 637 ADG 639 Score = 126 bits (316), Expect = 1e-29, Method: Composition-based stats. Identities = 30/199 (15%), Positives = 74/199 (37%), Gaps = 11/199 (5%) Query: 91 ERGILVASDSGAVELWELDENETL------IVSKFCKYEHDDIVSTVSVLSSGTQAVSGS 144 +L AS+ ++ W + + VS++ ++ H+ ++ +SV + + + S Sbjct: 451 PEFLLTASNDLTIKKWIIPKPTASMDVQIIKVSEYTRHAHEKDINALSVSPNDSIFATAS 510 Query: 145 KDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPAS 204 D K+W+L + ++ H + V+ D + + S D + +W Sbjct: 511 YDKTCKIWNLENGELEATLANHKRGLWDVSFC-QYDKLLATSSGDKTVKIWSLDTFSVMK 569 Query: 205 QIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFS 264 + ++ +Q ++ G +G + + D S C+ + H+ + L + Sbjct: 570 TLE--GHTNAVQRCSFINKQKQLISCGA-DGLIKIWDCSSGECLKTLDGHNNRLWALS-T 625 Query: 265 PHSVPFLASLSEDCSLAVL 283 + + S D Sbjct: 626 MNDGDMIVSADADGVFQFW 644 Score = 114 bits (286), Expect = 4e-26, Method: Composition-based stats. Identities = 50/262 (19%), Positives = 101/262 (38%), Gaps = 28/262 (10%) Query: 83 VADLTWVGER--GILVASDSGAVELW---ELDENETLIVSKFCKY-EHDDIVSTVSVLSS 136 +AD+ +VG + +A++S ++ + +L E + Y H+D+++++ Sbjct: 340 IADMRYVGPELNKLALATNSPSLRIIPVPDLSGPEASLPLDVEIYEGHEDLLNSLDATED 399 Query: 137 GTQAVSGSKDICIKVWDLAQQVV----LSSYRAHAAQVTCV----AASPHKDSVFLSCSE 188 G + SKD VW + + Y H+A VT V S L+ S Sbjct: 400 GLWIATASKDNTAIVWRYNENSCKFDIYAKYIGHSAAVTAVGLPNIVSKGYPEFLLTASN 459 Query: 189 DNRILLWDTRCPK--------PASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLV 240 D I W P S+ A +L+ P S +F + T + Sbjct: 460 DLTIKKWIIPKPTASMDVQIIKVSEYTRHAHEKDINALSVSPNDS-IFATASYDKTCKIW 518 Query: 241 DTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRS-QAHRDF 299 + ++ + A H + + + F + LA+ S D ++ + + ++ + H + Sbjct: 519 NLENGELEATLANHKRGLWDVSFCQYD-KLLATSSGDKTVKIWSLDTFSVMKTLEGHTNA 577 Query: 300 VRDATWSPLNHSL-LTTVGWDH 320 V+ ++ +N L + G D Sbjct: 578 VQRCSF--INKQKQLISCGADG 597 Score = 109 bits (271), Expect = 3e-24, Method: Composition-based stats. Identities = 27/152 (17%), Positives = 47/152 (30%), Gaps = 8/152 (5%) Query: 90 GERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICI 149 + AS ++W L+ E + H + VS + S D + Sbjct: 502 NDSIFATASYDKTCKIWNLENGE----LEATLANHKRGLWDVSFCQYDKLLATSSGDKTV 557 Query: 150 KVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCS 209 K+W L V+ + H V + +K +SC D I +WD + + Sbjct: 558 KIWSLDTFSVMKTLEGHTNAVQRCSF-INKQKQLISCGADGLIKIWDCSSGECLKTLDGH 616 Query: 210 APGYLPTSLAWHPQQSEVFVFGDENGTVSLVD 241 S ++ V D +G Sbjct: 617 NNRLWALSTM---NDGDMIVSADADGVFQFWK 645 Score = 91.7 bits (226), Expect = 4e-19, Method: Composition-based stats. Identities = 34/193 (17%), Positives = 72/193 (37%), Gaps = 24/193 (12%) Query: 15 REWNLPPNAPACMERQL----EAARY--RSDGALLLGASSLS-----GRCWAGSLWLFKD 63 ++W +P A M+ Q+ E R+ D L + + S +W + Sbjct: 464 KKWIIP-KPTASMDVQIIKVSEYTRHAHEKDINALSVSPNDSIFATASYDKTCKIW---N 519 Query: 64 PCAAPNEGFCSAGVQTEAGVADLTWVG-ERGILVASDSGAVELWELDENETLIVSKFCKY 122 E + + G+ D+++ ++ + +S V++W LD + + Sbjct: 520 LENGELEATLANHKR---GLWDVSFCQYDKLLATSSGDKTVKIWSLDTFSVMKTLE---- 572 Query: 123 EHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSV 182 H + V S ++ Q +S D IK+WD + L + H ++ ++ + + Sbjct: 573 GHTNAVQRCSFINKQKQLISCGADGLIKIWDCSSGECLKTLDGHNNRLWALSTM-NDGDM 631 Query: 183 FLSCSEDNRILLW 195 +S D W Sbjct: 632 IVSADADGVFQFW 644 Score = 78.2 bits (191), Expect = 5e-15, Method: Composition-based stats. Identities = 33/193 (17%), Positives = 66/193 (34%), Gaps = 16/193 (8%) Query: 69 NEGFCSAGVQTEAGVADLTWVGERGIL-VASDSGAVELWELDENETLIVSKFCKYEHDDI 127 G ++ + L +L V G++ + ++ E ++ K H Sbjct: 91 KTGKVVRSMKISSPSYILDADSTSTLLAVGGTDGSIIVVDI---ENGYITHSFK-GHGGT 146 Query: 128 VSTVSVLSSGT----QAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAA----SPHK 179 +S++ SG + +KVWDL ++ L + + H + V + + Sbjct: 147 ISSLKFYGQLNSKIWLLASGDTNGMVKVWDLVKRKCLHTLQEHTSAVRGLDIIEVPDNDE 206 Query: 180 DSV-FLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAW--HPQQSEVFVFGDENGT 236 S+ LS D+ I LWD K + S + + + Sbjct: 207 PSLNLLSGGRDDIINLWDFNMKKKCKLLKTLPVNQQVESCGFLKDGDGKRIIYTAGGDAI 266 Query: 237 VSLVDTKSTSCVL 249 L+D++S S + Sbjct: 267 FQLIDSESGSVLK 279 Score = 74.8 bits (182), Expect = 5e-14, Method: Composition-based stats. Identities = 38/218 (17%), Positives = 80/218 (36%), Gaps = 14/218 (6%) Query: 79 TEAGVADLTWVGERGILVASDS-GAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSG 137 AG + + V E G ++A+ + + +L I+ K + + ++ + + G Sbjct: 15 IYAGSSAVATVSENGKILATPVLDEINIIDLTPGSRKILHKISNEDEQE-ITALKLTPDG 73 Query: 138 TQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDT 197 S+ +K++ L V+ S + ++ + A ++ D I++ D Sbjct: 74 QYLTYVSQAQLLKIFHLKTGKVVRSMKI-SSPSYILDADST-STLLAVGGTDGSIIVVDI 131 Query: 198 RCPKPASQIGCSAPGYLPTSLAWHPQQSE---VFVFGDENGTVSLVDTKSTSCVLSSAVH 254 G +SL ++ Q + + GD NG V + D C+ + H Sbjct: 132 ENGYITHSFK--GHGGTISSLKFYGQLNSKIWLLASGDTNGMVKVWDLVKRKCLHTLQEH 189 Query: 255 SQCVTGLVF-----SPHSVPFLASLSEDCSLAVLDSSL 287 + V GL + L S D + + D ++ Sbjct: 190 TSAVRGLDIIEVPDNDEPSLNLLSGGRDDIINLWDFNM 227 Score = 62.8 bits (151), Expect = 2e-10, Method: Composition-based stats. Identities = 46/279 (16%), Positives = 86/279 (30%), Gaps = 39/279 (13%) Query: 90 GERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICI 149 G+R I A +L + + L + K + + V + S +Q D + Sbjct: 254 GKRIIYTAGGDAIFQLIDSESGSVLK--RTNKPIEELFIIGVLPILSNSQMFLVLSDQTL 311 Query: 150 KVWDLAQQ--------VVLSSYRAHAAQVTCVAASPHKDSVFL----SCSEDNRILLWDT 197 ++ ++ + V SS + + + + + S S I + D Sbjct: 312 QLINVEEDLKNDEDTIQVTSSIAGNHGIIADMRYVGPELNKLALATNSPSL-RIIPVPDL 370 Query: 198 RCPK---PASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSC----VLS 250 P+ P L SL + ++ T + SC Sbjct: 371 SGPEASLPLDVEIYEGHEDLLNSLD-ATEDGLWIATASKDNTAIVWRYNENSCKFDIYAK 429 Query: 251 SAVHSQCVTGL----VFSPHSVPFLASLSEDCSLAVL---------DSSLSEL--FRSQA 295 HS VT + + S FL + S D ++ D + ++ + A Sbjct: 430 YIGHSAAVTAVGLPNIVSKGYPEFLLTASNDLTIKKWIIPKPTASMDVQIIKVSEYTRHA 489 Query: 296 HRDFVRDATWSPLNHSLLTTVGWDHQVVHHVVPTEPLPA 334 H + + SP N S+ T +D + L A Sbjct: 490 HEKDINALSVSP-NDSIFATASYDKTCKIWNLENGELEA 527 >5K1B-B nrPDB Length = 677 Score = 128 bits (322), Expect = 3e-30, Method: Composition-based stats. Identities = 44/253 (17%), Positives = 93/253 (36%), Gaps = 18/253 (7%) Query: 82 GVADLTWVGE-RGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQA 140 GV L + A + +W +++++ H D V+ + + +G Sbjct: 32 GVNALQLDPALNRLFTAGRDSIIRIWSVNQHK-QDPYIASMEHHTDWVNDIVLCCNGKTL 90 Query: 141 VSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCP 200 +S S D +KVW+ + +S+ R H V +A + K + S D +I LWD Sbjct: 91 ISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDK-ELVASAGLDRQIFLWDVNT- 148 Query: 201 KPASQIGCSAPGYLPTSLAWHPQQ---------SEVFVFGDENGTVSLVDTKSTSCVLSS 251 + + S +SL+ + + V G + + D ++ + ++ Sbjct: 149 --LTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKL 206 Query: 252 AVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRS-QAHRDFVRDATWSPLNH 310 H+ V L+ + L S S D ++ + + + H + V + Sbjct: 207 KGHTDNVKALLLNRDGTQCL-SGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFT 265 Query: 311 SLLTTVGWDHQVV 323 + + G D ++ Sbjct: 266 HVY-SGGRDRKIY 277 Score = 102 bits (255), Expect = 2e-22, Method: Composition-based stats. Identities = 30/212 (14%), Positives = 75/212 (35%), Gaps = 19/212 (8%) Query: 124 HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVV---LSSYRAHAAQVTCVAASPHKD 180 + + V+ + + + + + +D I++W + Q ++S H V + Sbjct: 29 NRNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLC-CNG 87 Query: 181 SVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLV 240 +S S D + +W+ S + +LA+ + E+ + + L Sbjct: 88 KTLISASSDTTVKVWNAHKGFCMSTLR--THKDYVKALAYA-KDKELVASAGLDRQIFLW 144 Query: 241 DTKSTSCV---------LSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSL-SEL 290 D + + + S + + + L + + S S + L V D ++L Sbjct: 145 DVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGT-IIVSGSTEKVLRVWDPRTCAKL 203 Query: 291 FRSQAHRDFVRDATWSPLNHSLLTTVGWDHQV 322 + + H D V+ + + + + D + Sbjct: 204 MKLKGHTDNVKALLLN-RDGTQCLSGSSDGTI 234 Score = 102 bits (253), Expect = 3e-22, Method: Composition-based stats. Identities = 43/211 (20%), Positives = 71/211 (33%), Gaps = 25/211 (11%) Query: 94 ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWD 153 I+ S + +W+ L+ K H D V + + GTQ +SGS D I++W Sbjct: 183 IVSGSTEKVLRVWDPRTCAKLMKLK----GHTDNVKALLLNRDGTQCLSGSSDGTIRLWS 238 Query: 154 LAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGY 213 L QQ +++YR H V + + V+ S D +I D R P I Sbjct: 239 LGQQRCIATYRVHDEGVWALQVNDAFTHVY-SGGRDRKIYCTDLRNPDIRVLICEEKAPV 297 Query: 214 LPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVH----SQCVTGLVFSP---- 265 L L TV+ K +S + + +T L P Sbjct: 298 LKMELDRSADPPPAIWVATTKSTVNKWTLKGIHNFRASGDYDNDCTNPITPLCTQPDQVI 357 Query: 266 ------------HSVPFLASLSEDCSLAVLD 284 + + + + ++A D Sbjct: 358 KGGASIIQCHILNDKRHILTKDTNNNVAYWD 388 >6Q8F-A nrPDB Length = 514 Score = 127 bits (319), Expect = 7e-30, Method: Composition-based stats. Identities = 37/222 (16%), Positives = 72/222 (32%), Gaps = 19/222 (8%) Query: 117 SKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAH--------AA 168 S+ K+ V G V+GS D I+VW+ + + Sbjct: 207 SRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDD 266 Query: 169 QVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVF 228 V C+ S + + ++D +I +W + + + A T L++ S++ Sbjct: 267 AVLCMCFS-RDTEMLATGAQDGKIKVWKIQSGQCLRRF-ERAHSKGVTCLSFSKDSSQIL 324 Query: 229 VFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLS 288 + T+ + KS + HS V F+ ++ S S D ++ + + + Sbjct: 325 -SASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGH-YIISASSDGTVKIWNMKTT 382 Query: 289 ELF-------RSQAHRDFVRDATWSPLNHSLLTTVGWDHQVV 323 E + V P N + VV Sbjct: 383 ECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVV 424 Score = 125 bits (314), Expect = 3e-29, Method: Composition-based stats. Identities = 57/309 (18%), Positives = 112/309 (36%), Gaps = 30/309 (9%) Query: 30 QLEAARYRSDGALLLGASSLSGRCWAGSLWLF------KDPCAAPNEGFCSAGVQTEAGV 83 +E AR+ DG L+ S+ G +W F KD + F + + V Sbjct: 217 HVECARFSPDGQYLV-TGSVDGFI---EVWNFTTGKIRKDLKYQAQDNF----MMMDDAV 268 Query: 84 ADLTWVGERGIL-VASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVS 142 + + + +L + G +++W++ + L + H V+ +S +Q +S Sbjct: 269 LCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERA---HSKGVTCLSFSKDSSQILS 325 Query: 143 GSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKP 202 S D I++ L L +R H++ V +S S D + +W+ + + Sbjct: 326 ASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATF-TQDGHYIISASSDGTVKIWNMKTTEC 384 Query: 203 ASQIGC----SAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSS---AVHS 255 ++ + S+ P+ E FV + + TV +++ + V S Sbjct: 385 SNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQ-GQIVRSFSSGKREG 443 Query: 256 QCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQA-HRDFVRDATWSPLNHSLLT 314 SP ++ + ED L + +L R+ H V P +L+ Sbjct: 444 GDFVCCALSPRGE-WIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPH-QNLIA 501 Query: 315 TVGWDHQVV 323 T D + Sbjct: 502 TYSEDGLLK 510 Score = 79.8 bits (195), Expect = 2e-15, Method: Composition-based stats. Identities = 34/212 (16%), Positives = 62/212 (29%), Gaps = 58/212 (27%) Query: 82 GVADLTWVGER-GILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQA 140 GV L++ + IL AS + + L +TL + H V+ + G Sbjct: 310 GVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFR----GHSSFVNEATFTQDGHYI 365 Query: 141 VSGSKDICIKVWDLAQQVVLSSYR------AHAAQVTCVAASPHKDSVFLSC-------- 186 +S S D +K+W++ ++++ V V P F+ C Sbjct: 366 ISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVI 425 Query: 187 ------------------------------------SEDNRILLWDTRCPKPASQIGCSA 210 ED + + T K + + Sbjct: 426 MNMQGQIVRSFSSGKREGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTL--TV 483 Query: 211 PGYLPTSLAWHPQQSEVFVFGDENGTVSLVDT 242 +A HP Q+ + E+G + L Sbjct: 484 HEKDVIGIAHHPHQN-LIATYSEDGLLKLWKP 514 >4AEZ-A nrPDB Length = 401 Score = 127 bits (319), Expect = 7e-30, Method: Composition-based stats. Identities = 46/261 (17%), Positives = 91/261 (34%), Gaps = 12/261 (4%) Query: 65 CAAPNEGFCSAGVQTEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEH 124 P + G+ + + L W ++ + V +W D VS + + Sbjct: 78 NTTPERVLDAPGIIDDYYLNLLDWSN-LNVVAVALERNVYVWNADSGS---VSALAETDE 133 Query: 125 DDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFL 184 V++V G+ G + + ++D+ Q L + H A+V C++ + V Sbjct: 134 STYVASVKWSHDGSFLSVGLGNGLVDIYDVESQTKLRTMAGHQARVGCLSWN---RHVLS 190 Query: 185 SCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKS 244 S S I D R LAW + G + V + D +S Sbjct: 191 SGSRSGAIHHHDVRI-ANHQIGTLQGHSSEVCGLAWRSDGLQ-LASGGNDNVVQIWDARS 248 Query: 245 TSCVLSSAVHSQCVTGLVFSPHSVPFLASLS--EDCSLAVLDSSLSELFRSQAHRDFVRD 302 + + H+ V + + P LA+ D + +++ + V Sbjct: 249 SIPKFTKTNHNAAVKAVAWCPWQSNLLATGGGTMDKQIHFWNAATGARVNTVDAGSQVTS 308 Query: 303 ATWSPLNHSLLTTVGW-DHQV 322 WSP + +++T G+ D+ + Sbjct: 309 LIWSPHSKEIMSTHGFPDNNL 329 Score = 98.3 bits (243), Expect = 4e-21, Method: Composition-based stats. Identities = 45/209 (21%), Positives = 76/209 (36%), Gaps = 13/209 (6%) Query: 80 EAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQ 139 +A V L+W + S SGA+ ++ I + H V ++ S G Q Sbjct: 176 QARVGCLSW-NRHVLSSGSRSGAIHHHDVRIANHQIGT---LQGHSSEVCGLAWRSDGLQ 231 Query: 140 AVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCS--EDNRILLWDT 197 SG D +++WD + + H A V VA P + ++ + D +I W+ Sbjct: 232 LASGGNDNVVQIWDARSSIPKFTKTNHNAAVKAVAWCPWQSNLLATGGGTMDKQIHFWNA 291 Query: 198 RCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVF-GDENGTVSLVDTKSTSCVLSSA--VH 254 + + G TSL W P E+ G + +S+ S+ H Sbjct: 292 ATGARVNTVDA---GSQVTSLIWSPHSKEIMSTHGFPDNNLSIWSYSSSGLTKQVDIPAH 348 Query: 255 SQCVTGLVFSPHSVPFLASLSEDCSLAVL 283 V SP L++ + D +L Sbjct: 349 DTRVLYSALSPDG-RILSTAASDENLKFW 376 Score = 39.7 bits (91), Expect = 0.002, Method: Composition-based stats. Identities = 13/90 (14%), Positives = 29/90 (32%), Gaps = 5/90 (5%) Query: 71 GFCSAGVQTEAGVADLTWVGERGILVASD---SGAVELWELDENETLIVSKFCKYEHDDI 127 G V + V L W ++++ + +W + + + HD Sbjct: 294 GARVNTVDAGSQVTSLIWSPHSKEIMSTHGFPDNNLSIWSYSS--SGLTKQVDIPAHDTR 351 Query: 128 VSTVSVLSSGTQAVSGSKDICIKVWDLAQQ 157 V ++ G + + D +K W + Sbjct: 352 VLYSALSPDGRILSTAASDENLKFWRVYDG 381 >3FM0-A nrPDB Length = 345 Score = 124 bits (310), Expect = 8e-29, Method: Composition-based stats. Identities = 50/270 (18%), Positives = 97/270 (35%), Gaps = 35/270 (12%) Query: 83 VADLTWVGERGIL-VASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAV 141 V + W L AS +W+ ++++ V+ H++ V +V+ SG Sbjct: 64 VRKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTL--EGHENEVKSVAWAPSGNLLA 121 Query: 142 SGSKDICIKVWDLAQQ---VVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTR 198 + S+D + VW++ ++ +S +H V V P + + S S D+ + L+ Sbjct: 122 TCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQ-ELLASASYDDTVKLYREE 180 Query: 199 CPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLV---------------DTK 243 SLA+ P + ++ TV + Sbjct: 181 EDDWVCCATLEGHESTVWSLAFDP-SGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDP 239 Query: 244 STSCVLSSAV-HSQCVTGLVFSPHSVPFLASLSEDCSLAVL--DSSLSELFRS------- 293 S C+ + + HS+ + + + + LA+ D ++ V D + + Sbjct: 240 SWKCICTLSGFHSRTIYDIAWCQLTGA-LATACGDDAIRVFQEDPNSDPQQPTFSLTAHL 298 Query: 294 -QAHRDFVRDATWSPLNHSLLTTVGWDHQV 322 QAH V W+P LL + D +V Sbjct: 299 HQAHSQDVNCVAWNPKEPGLLASCSDDGEV 328 Score = 113 bits (282), Expect = 1e-25, Method: Composition-based stats. Identities = 45/232 (19%), Positives = 79/232 (34%), Gaps = 27/232 (11%) Query: 80 EAGVADLTWVGERGILVA-SDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGT 138 E V + W +L S +V +WE+DE + H V V S Sbjct: 105 ENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLN-SHTQDVKHVVWHPSQE 163 Query: 139 QAVSGSKDICIKVWDLAQQ--VVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWD 196 S S D +K++ + V ++ H + V +A P SCS+D + +W Sbjct: 164 LLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPS-GQRLASCSDDRTVRIWR 222 Query: 197 TRCPKPASQIGCSAPGYLPTSLA----WHPQQ---------SEVFVFGDENGTVSLV--- 240 P + CS + +H + + + + + Sbjct: 223 QYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQLTGALATACGDDAIRVFQED 282 Query: 241 ---DTKSTSCVLSSA---VHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSS 286 D + + L++ HSQ V + ++P LAS S+D +A Sbjct: 283 PNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPKEPGLLASCSDDGEVAFWKYQ 334 Score = 111 bits (277), Expect = 5e-25, Method: Composition-based stats. Identities = 40/201 (19%), Positives = 66/201 (32%), Gaps = 13/201 (6%) Query: 131 VSVLSSGTQAVSGSKDICIKVW--DLAQQVVLSSY-RAHAAQVTCVAASPHKDSVFLSCS 187 ++ +GT S D I++W + + S H V VA SP + S S Sbjct: 22 LAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSP-CGNYLASAS 80 Query: 188 EDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTS- 246 D +W S+AW P + + +V + + Sbjct: 81 FDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAP-SGNLLATCSRDKSVWVWEVDEEDE 139 Query: 247 --CVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVL---DSSLSELFRSQAHRDFVR 301 CV H+Q V +V+ P LAS S D ++ + + + H V Sbjct: 140 YECVSVLNSHTQDVKHVVWHPSQE-LLASASYDDTVKLYREEEDDWVCCATLEGHESTVW 198 Query: 302 DATWSPLNHSLLTTVGWDHQV 322 + P + L + D V Sbjct: 199 SLAFDP-SGQRLASCSDDRTV 218 Score = 99.0 bits (245), Expect = 3e-21, Method: Composition-based stats. Identities = 36/179 (20%), Positives = 63/179 (35%), Gaps = 12/179 (6%) Query: 155 AQQVVLSSYRAH-AAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPA-SQIGCSAPG 212 V+L AH ++ +A +P ++ SC D RI +W T + Sbjct: 3 DSLVLLGRVPAHPDSRCWFLAWNPA-GTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQ 61 Query: 213 YLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTS--CVLSSAVHSQCVTGLVFSPHSVPF 270 +AW P + + T + CV + H V + ++P Sbjct: 62 RTVRKVAWSPCGNY-LASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSG-NL 119 Query: 271 LASLSEDCSLAVLDSSLSELFR----SQAHRDFVRDATWSPLNHSLLTTVGWDHQVVHH 325 LA+ S D S+ V + + + +H V+ W P LL + +D V + Sbjct: 120 LATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQE-LLASASYDDTVKLY 177 Score = 89.0 bits (219), Expect = 3e-18, Method: Composition-based stats. Identities = 38/238 (15%), Positives = 83/238 (34%), Gaps = 37/238 (15%) Query: 36 YRSDGALLLGASSLSGRCWAG-----SLWLFKDPCAAPNEGFCSAGVQTEAG-VADLTWV 89 + ++ + A SG A S+W+++ +E C + + + V + W Sbjct: 104 HENEVKSVAWAP--SGNLLATCSRDKSVWVWEVDEE--DEYECVSVLNSHTQDVKHVVWH 159 Query: 90 GERGIL-VASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDIC 148 + +L AS V+L+ E E V H+ V +++ SG + S S D Sbjct: 160 PSQELLASASYDDTVKLY--REEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRT 217 Query: 149 IKVW---------------DLAQQVVLSSYRA-HAAQVTCVAASPHKDSVFLSCSEDNRI 192 +++W + + H+ + +A ++ +C +D I Sbjct: 218 VRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQLTGALATACGDD-AI 276 Query: 193 LLWDTRCPKPASQ-------IGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTK 243 ++ Q A +AW+P++ + ++G V+ + Sbjct: 277 RVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPKEPGLLASCSDDGEVAFWKYQ 334 >5OQL-d nrPDB Length = 446 Score = 122 bits (306), Expect = 2e-28, Method: Composition-based stats. Identities = 45/235 (19%), Positives = 95/235 (40%), Gaps = 15/235 (6%) Query: 94 ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWD 153 I S G V++W+L + + H++IV ++ + + +S + D IK+WD Sbjct: 82 IASGSGDGVVKVWDLTTRDEE---TWRVAAHNNIVKGLTFTND-KKLLSCATDG-IKLWD 136 Query: 154 LAQQ----VVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCS 209 +++++ T ++ ++ S + I +WD I Sbjct: 137 PYASPSNTTPIATWQE-GGPYTSLSFHRSANTFAASSGQGC-IRIWDLEHSTAGQAIQWP 194 Query: 210 APGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVP 269 + T + ++ ++ V + ++ L D ++ V+ + +H C +VF+P Sbjct: 195 SFVDTITDVCFNQVETSVIGSVATDRSIILFDLRTNMPVIKTVLHFAC-NRIVFNPMEAM 253 Query: 270 FLASLSEDCSLAVLDSSL--SELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQV 322 LA SED ++ + D+ L + H V D +SP L + +D + Sbjct: 254 NLAVASEDHNIYIFDARNFDKALNIQKGHVAAVMDVEFSPTGEE-LVSGSYDRTI 307 Score = 108 bits (270), Expect = 3e-24, Method: Composition-based stats. Identities = 41/260 (15%), Positives = 93/260 (35%), Gaps = 50/260 (19%) Query: 83 VADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVS 142 V LT+ ++ +L + G ++LW+ + + ++ +++S S + Sbjct: 113 VKGLTFTNDKKLLSCATDG-IKLWDPYAS-PSNTTPIATWQEGGPYTSLSFHRSANTFAA 170 Query: 143 GSKDICIKVWDLAQQVVLSSYRAHA--AQVTCVAASPHKDSVFLSCSEDNRILLWDTRCP 200 S CI++WDL + + + +T V + + SV S + D I+L+D R Sbjct: 171 SSGQGCIRIWDLEHSTAGQAIQWPSFVDTITDVCFNQVETSVIGSVATDRSIILFDLRTN 230 Query: 201 KPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSS-AVHSQCVT 259 P + + + + ++P ++ E+ + + D ++ L+ H V Sbjct: 231 MP---VIKTVLHFACNRIVFNPMEAMNLAVASEDHNIYIFDARNFDKALNIQKGHVAAVM 287 Query: 260 GLVFSPHSV------------------------------------------PFLASLSED 277 + FSP ++ + S+D Sbjct: 288 DVEFSPTGEELVSGSYDRTIRLWRRDAGHSRDVYHTKRMQRVFRTMWTMDSKYILTGSDD 347 Query: 278 CSLAVLDSSLSELFRSQAHR 297 ++ + ++ SE +A R Sbjct: 348 GNVRLWRANASERSGVKATR 367 Score = 99.8 bits (247), Expect = 2e-21, Method: Composition-based stats. Identities = 44/207 (21%), Positives = 77/207 (37%), Gaps = 11/207 (5%) Query: 123 EHDDIVSTVSVLSSG-TQAVSGSKDICIKVWDLAQQ-VVLSSYRAHAAQVTCVAASPHKD 180 H V ++ + SGS D +KVWDL + AH V + + D Sbjct: 64 GHVQGVYSMCKDKNSLNCIASGSGDGVVKVWDLTTRDEETWRVAAHNNIVKGLTFT--ND 121 Query: 181 SVFLSCSEDNRILLWD-TRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSL 239 LSC+ D I LWD P + I G TSL++H + + F G + + Sbjct: 122 KKLLSCATDG-IKLWDPYASPSNTTPIATWQEGGPYTSLSFH-RSANTFAASSGQGCIRI 179 Query: 240 VD--TKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLS-ELFRSQAH 296 D + + +T + F+ + S++ D S+ + D + + ++ H Sbjct: 180 WDLEHSTAGQAIQWPSFVDTITDVCFNQVETSVIGSVATDRSIILFDLRTNMPVIKTVLH 239 Query: 297 RDFVRDATWSPLNHSLLTTVGWDHQVV 323 ++P+ L DH + Sbjct: 240 F-ACNRIVFNPMEAMNLAVASEDHNIY 265 Score = 73.2 bits (178), Expect = 1e-13, Method: Composition-based stats. Identities = 28/172 (16%), Positives = 62/172 (36%), Gaps = 13/172 (7%) Query: 165 AHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQ 224 H V + + + S S D + +WD + +A + L + Sbjct: 64 GHVQGVYSMCKDKNSLNCIASGSGDGVVKVWDLTT-RDEETWRVAAHNNIVKGLTF--TN 120 Query: 225 SEVFVFGDENGTVSLVD----TKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSL 280 + + +G + L D +T+ + + T L F + F AS S + Sbjct: 121 DKKLLSCATDG-IKLWDPYASPSNTTPIATWQE-GGPYTSLSFHRSANTFAAS-SGQGCI 177 Query: 281 AVLD---SSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQVVHHVVPT 329 + D S+ + + + D + D ++ + S++ +V D ++ + T Sbjct: 178 RIWDLEHSTAGQAIQWPSFVDTITDVCFNQVETSVIGSVATDRSIILFDLRT 229 Score = 49.7 bits (117), Expect = 2e-06, Method: Composition-based stats. Identities = 21/85 (24%), Positives = 36/85 (42%), Gaps = 6/85 (7%) Query: 253 VHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLS--ELFRSQAHRDFVRDATWSPLNH 310 H Q V + +S+ +AS S D + V D + E +R AH + V+ T++ N Sbjct: 64 GHVQGVYSMCKDKNSLNCIASGSGDGVVKVWDLTTRDEETWRVAAHNNIVKGLTFT--ND 121 Query: 311 SLLTTVGWDHQVVH--HVVPTEPLP 333 L + D + + P+ P Sbjct: 122 KKLLSCATDGIKLWDPYASPSNTTP 146 >6GMH-W nrPDB Length = 305 Score = 119 bits (298), Expect = 2e-27, Method: Composition-based stats. Identities = 42/239 (17%), Positives = 90/239 (37%), Gaps = 13/239 (5%) Query: 80 EAGVADLTWVGERG-----ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVL 134 + + + W + ++ S V++W+ + + ++ H V +V + Sbjct: 16 DDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWR--DERLDLQWSLEGHQLGVVSVDIS 73 Query: 135 SSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILL 194 + A S S D I++WDL + S A +A SP + + ++ + Sbjct: 74 HTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPD-SQYLATGTHVGKVNI 132 Query: 195 WDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVH 254 + K + G S+A+ P + G +G +++ D + + + H Sbjct: 133 FGVESGK--KEYSLDTRGKFILSIAYSP-DGKYLASGAIDGIINIFDIATGKLLHTLEGH 189 Query: 255 SQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELF-RSQAHRDFVRDATWSPLNHSL 312 + + L FSP S L + S+D + + D + L H +V + + P + Sbjct: 190 AMPIRSLTFSPDSQ-LLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHF 247 Score = 110 bits (276), Expect = 7e-25, Method: Composition-based stats. Identities = 47/251 (18%), Positives = 94/251 (37%), Gaps = 12/251 (4%) Query: 80 EAGVADLTWVGERGILVASD-SGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGT 138 + GV + I +S + LW+L+ + + K D T++ Sbjct: 64 QLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQI---KSIDAGPVDA-WTLAFSPDSQ 119 Query: 139 QAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTR 198 +G+ + ++ + S + +A SP S + D I ++D Sbjct: 120 YLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPD-GKYLASGAIDGIINIFDIA 178 Query: 199 CPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCV 258 K + A SL + P S++ V ++G + + D + + + + H+ V Sbjct: 179 TGKLLHTLEGHAM--PIRSLTFSP-DSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWV 235 Query: 259 TGLVFSPHSVPFLASLSEDCSLAVLDSSLSEL-FRSQAHRDFVRDATWSPLNHSLLTTVG 317 + F P F++S S+ S+ V D H+D V ++ N S + +VG Sbjct: 236 LNVAFCPDDTHFVSSSSD-KSVKVWDVGTRTCVHTFFDHQDQVWGVKYN-GNGSKIVSVG 293 Query: 318 WDHQVVHHVVP 328 D ++ + P Sbjct: 294 DDQEIHIYDCP 304 Score = 77.1 bits (188), Expect = 9e-15, Method: Composition-based stats. Identities = 33/219 (15%), Positives = 66/219 (30%), Gaps = 49/219 (22%) Query: 155 AQQVVLSSYRAHAAQVTCVAASPH---KDSVFLSCSEDNRILLWDTRCPKPASQIGCSAP 211 ++ +AH + VA + ++ S D+ + +W R + Q Sbjct: 4 QYGILFKQEQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGH 63 Query: 212 GYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAV------------------ 253 S+ + + + L D ++ + S Sbjct: 64 QLGVVSVDI-SHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLA 122 Query: 254 ---HSQCVT---------------------GLVFSPHSVPFLASLSEDCSLAVLDSSLSE 289 H V + +SP +LAS + D + + D + + Sbjct: 123 TGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDG-KYLASGAIDGIINIFDIATGK 181 Query: 290 LFRS-QAHRDFVRDATWSPLNHSLLTTVGWDHQVVHHVV 327 L + + H +R T+SP + LL T D + + V Sbjct: 182 LLHTLEGHAMPIRSLTFSP-DSQLLVTASDDGYIKIYDV 219 >5WYK-BB nrPDB Length = 943 Score = 118 bits (296), Expect = 3e-27, Method: Composition-based stats. Identities = 56/331 (16%), Positives = 113/331 (34%), Gaps = 48/331 (14%) Query: 19 LPPNAPACMERQLEAARYRS----------DGALLLGASSLSGRCWAGSLWLFKDPCAAP 68 P +PA ++ + + D LL AS+ S + W Sbjct: 372 RDPTSPAPLKTHTIELQGQRTDVRSIDISDDNKLLATASNGSLKIWNI------------ 419 Query: 69 NEGFCSAGVQTEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIV 128 C + + G +++ + +G ++L++L + L + HD + Sbjct: 420 KTHKCIRTFECGYALTCKFLPGGLLVILGTRNGELQLFDLASSSLLDTIEDA---HDAAI 476 Query: 129 STVSVLSSGTQAVSGSKDICIKVWDLA---------QQVVLSSYRAH-------AAQVTC 172 ++ + S G + V+GS D +K WD + L + H + C Sbjct: 477 WSLDLTSDGKRLVTGSADKTVKFWDFKVENSLVPGTKNKFLPVLKLHHDTTLELTDDILC 536 Query: 173 VAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGD 232 V SP + +S DN + ++ K + L +++ S++ + Sbjct: 537 VRVSPDDRYLAISL-LDNTVKVFFLDSMKFYLSLYGHKLPVLSIDISF---DSKMIITSS 592 Query: 233 ENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSE-LF 291 + + + C S H + + F P S F S S+D + D E + Sbjct: 593 ADKNIKIWGLDFGDCHKSLFAHQDSIMNVKFLPQSHNFF-SCSKDAVVKYWDGEKFECIQ 651 Query: 292 RSQAHRDFVRDATWSPLNHSLLTTVGWDHQV 322 + AH+ V + + + + DH + Sbjct: 652 KLYAHQSEVWALAVA-TDGGFVVSSSHDHSI 681 Score = 116 bits (291), Expect = 1e-26, Method: Composition-based stats. Identities = 40/225 (17%), Positives = 74/225 (32%), Gaps = 18/225 (8%) Query: 80 EAGVADLTWVGE-RGILVASDSGAVELWELDENETLIV------SKFCKYEHD------D 126 +A + L + + ++ S V+ W+ +L+ K HD D Sbjct: 473 DAAIWSLDLTSDGKRLVTGSADKTVKFWDFKVENSLVPGTKNKFLPVLKLHHDTTLELTD 532 Query: 127 IVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSC 186 + V V D +KV+ L S H V + S + ++ Sbjct: 533 DILCVRVSPDDRYLAISLLDNTVKVFFLDSMKFYLSLYGHKLPVLSIDIS-FDSKMIITS 591 Query: 187 SEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTS 246 S D I +W + A ++ + PQ F ++ V D + Sbjct: 592 SADKNIKIWGLDFGDCHKSL--FAHQDSIMNVKFLPQS-HNFFSCSKDAVVKYWDGEKFE 648 Query: 247 CVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELF 291 C+ H V L + F+ S S D S+ + + + ++F Sbjct: 649 CIQKLYAHQSEVWALAVATDGG-FVVSSSHDHSIRIWEETEDQVF 692 Score = 111 bits (277), Expect = 5e-25, Method: Composition-based stats. Identities = 31/151 (20%), Positives = 58/151 (38%), Gaps = 11/151 (7%) Query: 92 RGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKV 151 + V G +++W+L L+ H ++ + +GT+ +SGSKD I V Sbjct: 92 DLLAVGYADGVIKVWDLMSKTVLLNFN----GHKAAITLLQFDGTGTRLISGSKDSNIIV 147 Query: 152 WDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAP 211 WDL +V L R+H +T + +S S+D I LWD + + Sbjct: 148 WDLVGEVGLYKLRSHKDSITGFWC--QGEDWLISTSKDGMIKLWDLKTHQCIETHIAHTG 205 Query: 212 GYLPTSLAWHPQQSEVFVFGDENGTVSLVDT 242 ++ ++ + + V + Sbjct: 206 ECWGLAVK-----DDLLITTGTDSQVKIWKL 231 Score = 104 bits (258), Expect = 7e-23, Method: Composition-based stats. Identities = 31/150 (20%), Positives = 55/150 (36%), Gaps = 8/150 (5%) Query: 134 LSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRIL 193 G D IKVWDL + VL ++ H A +T + + +S S+D+ I+ Sbjct: 88 HKDTDLLAVGYADGVIKVWDLMSKTVLLNFNGHKAAITLLQFDGT-GTRLISGSKDSNII 146 Query: 194 LWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAV 253 +WD + T Q + + ++G + L D K+ C+ + Sbjct: 147 VWDLVG--EVGLYKLRSHKDSITGFWC--QGEDWLISTSKDGMIKLWDLKTHQCIETHIA 202 Query: 254 HSQCVTGLVFSPHSVPFLASLSEDCSLAVL 283 H+ GL L + D + + Sbjct: 203 HTGECWGLAV---KDDLLITTGTDSQVKIW 229 Score = 99.4 bits (246), Expect = 2e-21, Method: Composition-based stats. Identities = 36/317 (11%), Positives = 90/317 (28%), Gaps = 72/317 (22%) Query: 76 GVQTEAGVADLTWV----GERGILVASDSGAVELW-------ELDENETLIVSKFCKYEH 124 +++ + +W + +++ + S +E + + L Sbjct: 331 TIRSLYKIKSASWTTVSSSKLELVLTTSSNTIEYYSIPYEKRDPTSPAPLKTHTIELQGQ 390 Query: 125 DDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYR-------------------- 164 V ++ + + S + +K+W++ + ++ Sbjct: 391 RTDVRSIDISDDNKLLATAS-NGSLKIWNIKTHKCIRTFECGYALTCKFLPGGLLVILGT 449 Query: 165 ---------------------AHAAQVTCVAASPHKDSVFLSCSEDNRILLWDT------ 197 AH A + + + ++ S D + WD Sbjct: 450 RNGELQLFDLASSSLLDTIEDAHDAAIWSLDLTSD-GKRLVTGSADKTVKFWDFKVENSL 508 Query: 198 -----RCPKPASQIGCSAPGYLPTSLAW---HPQQSEVFVFGDENGTVSLVDTKSTSCVL 249 P ++ L + P + + + TV + S L Sbjct: 509 VPGTKNKFLPVLKLHHDTTLELTDDILCVRVSPDDRYLAIS-LLDNTVKVFFLDSMKFYL 567 Query: 250 SSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQ-AHRDFVRDATWSPL 308 S H V + S + + S D ++ + + +S AH+D + + + P Sbjct: 568 SLYGHKLPVLSIDIS-FDSKMIITSSADKNIKIWGLDFGDCHKSLFAHQDSIMNVKFLPQ 626 Query: 309 NHSLLTTVGWDHQVVHH 325 +H+ + D V + Sbjct: 627 SHNFF-SCSKDAVVKYW 642 Score = 91.3 bits (225), Expect = 5e-19, Method: Composition-based stats. Identities = 39/209 (18%), Positives = 66/209 (31%), Gaps = 22/209 (10%) Query: 134 LSSGTQAVSGSKDICIKVWDLAQQVVLSSYR----------AHAAQVTCVAASPHKDSVF 183 G S +D + +WD+ ++S A C HKD+ Sbjct: 36 SGPGQLITSALED--VNIWDIKTGDLVSKLSDGLPPGASDARGAKPAECTYLEAHKDTDL 93 Query: 184 LSCSE-DNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDT 242 L+ D I +WD + + T L + + G ++ + + D Sbjct: 94 LAVGYADGVIKVWDLMSKTVL--LNFNGHKAAITLLQFD-GTGTRLISGSKDSNIIVWDL 150 Query: 243 KSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQ-AHRDFVR 301 + H +TG F +L S S+D + + D + + AH Sbjct: 151 VGEVGLYKLRSHKDSITG--FWCQGEDWLISTSKDGMIKLWDLKTHQCIETHIAHTGECW 208 Query: 302 DATWSPLNHSLLTTVGWDHQVVHHVVPTE 330 + LL T G D QV + E Sbjct: 209 GLA---VKDDLLITTGTDSQVKIWKLDIE 234 Score = 51.3 bits (121), Expect = 5e-07, Method: Composition-based stats. Identities = 24/145 (16%), Positives = 45/145 (31%), Gaps = 10/145 (6%) Query: 196 DTRCPKPASQ--IGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAV 253 D P P I S+ +++ NG++ + + K+ C+ + Sbjct: 373 DPTSPAPLKTHTIELQGQRTDVRSIDI-SDDNKLLATAS-NGSLKIWNIKTHKCIRTFE- 429 Query: 254 HSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRS--QAHRDFVRDATWSPLNHS 311 F P + + + + L + D + S L + AH + + + Sbjct: 430 -CGYALTCKFLPGGL-LVILGTRNGELQLFDLASSSLLDTIEDAHDAAIWSLDLTS-DGK 486 Query: 312 LLTTVGWDHQVVHHVVPTEPLPAPG 336 L T D V E PG Sbjct: 487 RLVTGSADKTVKFWDFKVENSLVPG 511 Score = 43.6 bits (101), Expect = 1e-04, Method: Composition-based stats. Identities = 34/263 (12%), Positives = 72/263 (27%), Gaps = 67/263 (25%) Query: 90 GERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICI 149 GE ++ S G ++LW+L ++ + H ++V ++ D + Sbjct: 173 GEDWLISTSKDGMIKLWDLKTHQCIETH----IAHTGECWGLAV--KDDLLITTGTDSQV 226 Query: 150 KVW--DLAQQVVLSSY-------RAHAAQVTCVAA---SPHKDSVFLSCSEDNRILLWDT 197 K+W D+ + + + + S K S F + D I + Sbjct: 227 KIWKLDIENDKMGGKLTEMGIFEKQSKQRGLKIEFITNSSDKTSFFYIQNADKTIETFRI 286 Query: 198 RCPKPASQ----------------------------------IGCSAPGYLPTSLAWHPQ 223 R + ++ Y S +W Sbjct: 287 RKEEEIARGLKKREKRLKEKGLTEEEIAKSIKESYSSFILHPFQTIRSLYKIKSASWTTV 346 Query: 224 QSE---VFVFGDENGTVSL---VDTKSTSCVLSSAVHSQC-------VTGLVFSPHSVPF 270 S + + N + + + H+ V + S Sbjct: 347 SSSKLELVLTTSSNTIEYYSIPYEKRDPTSPAPLKTHTIELQGQRTDVRSIDIS-DDNKL 405 Query: 271 LASLSEDCSLAVLDSSLSELFRS 293 LA+ S + SL + + + R+ Sbjct: 406 LATAS-NGSLKIWNIKTHKCIRT 427 >2HES-X nrPDB Length = 330 Score = 118 bits (296), Expect = 3e-27, Method: Composition-based stats. Identities = 47/254 (18%), Positives = 90/254 (35%), Gaps = 26/254 (10%) Query: 94 ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVW- 152 + S ++L + ++ ++ + H + +V+ + +GS D + +W Sbjct: 27 LATGSTDRKIKLVSVKYDDFTLIDVLDETAHKKAIRSVAWRPHTSLLAAGSFDSTVSIWA 86 Query: 153 -----DLAQQV-VLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDT-RCPKPASQ 205 D ++ +L+ H +V VA S + +CS D + +W+T + Sbjct: 87 KEESADRTFEMDLLAIIEGHENEVKGVAWS-NDGYYLATCSRDKSVWIWETDESGEEYEC 145 Query: 206 IG-CSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVD--TKSTSCVLSSAVHSQCVTGLV 262 I + WHP + + TV + CV H V Sbjct: 146 ISVLQEHSQDVKHVIWHP-SEALLASSSYDDTVRIWKDYDDDWECVAVLNGHEGTVWSSD 204 Query: 263 FSPHSVPF-LASLSEDCSLAVL-----DSSLSELFRSQA-----HRDFVRDATWSPLNHS 311 F F L S S+D ++ V D + + +A H+ V + W N Sbjct: 205 FDKTEGVFRLCSGSDDSTVRVWKYMGDDEDDQQEWVCEAILPDVHKRQVYNVAWG-FNG- 262 Query: 312 LLTTVGWDHQVVHH 325 L+ +VG D + + Sbjct: 263 LIASVGADGVLAVY 276 Score = 93.3 bits (230), Expect = 1e-19, Method: Composition-based stats. Identities = 40/208 (19%), Positives = 70/208 (33%), Gaps = 20/208 (9%) Query: 132 SVLSSGTQAVSGSKDICIKV----WDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCS 187 S S +GS D IK+ +D + + AH + VA PH S+ + S Sbjct: 19 SFDFSQGILATGSTDRKIKLVSVKYDDFTLIDVLDETAHKKAIRSVAWRPH-TSLLAAGS 77 Query: 188 EDNRILLW-DTRCPKPASQIGC----SAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDT 242 D+ + +W ++ +AW + +V + +T Sbjct: 78 FDSTVSIWAKEESADRTFEMDLLAIIEGHENEVKGVAW-SNDGYYLATCSRDKSVWIWET 136 Query: 243 KSTS----CVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVL---DSSLSELFRSQA 295 + C+ HSQ V +++ P S LAS S D ++ + D + Sbjct: 137 DESGEEYECISVLQEHSQDVKHVIWHP-SEALLASSSYDDTVRIWKDYDDDWECVAVLNG 195 Query: 296 HRDFVRDATWSPLNH-SLLTTVGWDHQV 322 H V + + L + D V Sbjct: 196 HEGTVWSSDFDKTEGVFRLCSGSDDSTV 223 Score = 92.5 bits (228), Expect = 2e-19, Method: Composition-based stats. Identities = 36/221 (16%), Positives = 68/221 (30%), Gaps = 20/221 (9%) Query: 80 EAGVADLTWVGERGILVA-SDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGT 138 E V + W + L S +V +WE DE+ EH V V S Sbjct: 107 ENEVKGVAWSNDGYYLATCSRDKSVWIWETDESGEEYECISVLQEHSQDVKHVIWHPSEA 166 Query: 139 QAVSGSKDICIKVW-DLAQQV-VLSSYRAHAAQVTCVAASPHKD-SVFLSCSEDNRILLW 195 S S D +++W D ++ H V + S S+D+ + +W Sbjct: 167 LLASSSYDDTVRIWKDYDDDWECVAVLNGHEGTVWSSDFDKTEGVFRLCSGSDDSTVRVW 226 Query: 196 -----DTRCPKPA--SQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCV 248 D + I ++AW + + +G +++ + Sbjct: 227 KYMGDDEDDQQEWVCEAILPDVHKRQVYNVAW--GFNGLIASVGADGVLAVYEEVDGE-W 283 Query: 249 LSSAV----H-SQCVTGLVFSP-HSVPFLASLSEDCSLAVL 283 A H + + + + LA+ +D + Sbjct: 284 KVFAKRALCHGVYEINVVKWLELNGKTILATGGDDGIVNFW 324 Score = 48.6 bits (114), Expect = 4e-06, Method: Composition-based stats. Identities = 35/231 (15%), Positives = 71/231 (30%), Gaps = 68/231 (29%) Query: 28 ERQLEAARYRSDGALLLGASSLSGRCWAGSLWLFKDPCAAPNEGFCSAGVQTEAG-VADL 86 E +++ + +DG L S S+W+++ + E C + +Q + V + Sbjct: 107 ENEVKGVAWSNDGYYLATCSR------DKSVWIWETDESG-EEYECISVLQEHSQDVKHV 159 Query: 87 TWVG-ERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGT--QAVSG 143 W E + +S V +W+ +++ V+ H+ V + + + SG Sbjct: 160 IWHPSEALLASSSYDDTVRIWKDYDDDWECVA--VLNGHEGTVWSSDFDKTEGVFRLCSG 217 Query: 144 SKDICIKVW-------DLAQQVVLSSY--RAHAAQVTCVAA------------------- 175 S D ++VW D Q+ V + H QV VA Sbjct: 218 SDDSTVRVWKYMGDDEDDQQEWVCEAILPDVHKRQVYNVAWGFNGLIASVGADGVLAVYE 277 Query: 176 ---------------------------SPHKDSVFLSCSEDNRILLWDTRC 199 + ++ + +D + W Sbjct: 278 EVDGEWKVFAKRALCHGVYEINVVKWLELNGKTILATGGDDGIVNFWSLEK 328 >4GGA-A nrPDB Length = 420 Score = 118 bits (295), Expect = 4e-27, Method: Composition-based stats. Identities = 40/239 (16%), Positives = 81/239 (33%), Gaps = 16/239 (6%) Query: 77 VQTEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSS 136 ++ + + + W +L + +V LW + L + + + +S+V+ + Sbjct: 102 IRNDYYLNLVDWSS-GNVLAVALDNSVYLWSASSGDILQLLQMEQPGE--YISSVAWIKE 158 Query: 137 GTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWD 196 G G+ +++WD+ QQ L + +H+A+V ++ + + S S I D Sbjct: 159 GNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWN---SYILSSGSRSGHIHHHD 215 Query: 197 TRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTS----CVLSSA 252 R S L W P G + V++ + + + Sbjct: 216 VRV-AEHHVATLSGHSQEVCGLRWAP-DGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFT 273 Query: 253 VHSQCVTGLVFSPHSVPFLASLS--EDCSLAVLDSSLSELFR-SQAHRDFVRDATWSPL 308 H V + + P LA+ D + + + AH WSP Sbjct: 274 QHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCS-ILWSPH 331 Score = 107 bits (266), Expect = 1e-23, Method: Composition-based stats. Identities = 43/210 (20%), Positives = 72/210 (34%), Gaps = 15/210 (7%) Query: 81 AGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQA 140 A V L+W + S SG + ++ E + + H V + G Sbjct: 190 ARVGSLSW-NSYILSSGSRSGHIHHHDVRVAEHHVAT---LSGHSQEVCGLRWAPDGRHL 245 Query: 141 VSGSKDICIKVWDLAQQV----VLSSYRAHAAQVTCVAASPHKDSVFLSCS--EDNRILL 194 SG D + VW A L ++ H V VA P + +V + D I + Sbjct: 246 ASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRI 305 Query: 195 WDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVF-GDENGTVSLVDTKSTSCVLSSAV 253 W+ S + + S+ W P E+ G + + + + V Sbjct: 306 WNVCSGACLSAVDAHSQ---VCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKG 362 Query: 254 HSQCVTGLVFSPHSVPFLASLSEDCSLAVL 283 H+ V L SP +AS + D +L + Sbjct: 363 HTSRVLSLTMSPDGAT-VASAAADETLRLW 391 Score = 87.1 bits (214), Expect = 1e-17, Method: Composition-based stats. Identities = 43/203 (21%), Positives = 79/203 (38%), Gaps = 17/203 (8%) Query: 123 EHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHA--AQVTCVAASPHKD 180 +D ++ V S AV + D + +W + +L + ++ VA + Sbjct: 103 RNDYYLNLVDWSSGNVLAV--ALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGN 160 Query: 181 SVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLV 240 + + S + LWD + K + ++ SL+W+ S + G +G + Sbjct: 161 YLAVGTSS-AEVQLWDVQQQKRLRNM--TSHSARVGSLSWN---SYILSSGSRSGHIHHH 214 Query: 241 DTK-STSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVL-----DSSLSELFRSQ 294 D + + V + + HSQ V GL ++P LAS D + V + L Sbjct: 215 DVRVAEHHVATLSGHSQEVCGLRWAPDG-RHLASGGNDNLVNVWPSAPGEGGWVPLQTFT 273 Query: 295 AHRDFVRDATWSPLNHSLLTTVG 317 H+ V+ W P ++L T G Sbjct: 274 QHQGAVKAVAWCPWQSNVLATGG 296 Score = 58.6 bits (140), Expect = 3e-09, Method: Composition-based stats. Identities = 30/180 (16%), Positives = 58/180 (32%), Gaps = 17/180 (9%) Query: 36 YRSDGALLLGASSLSGRCWAGSLWLFKDPCAAPNEGFCSAGVQTEAG----VADLTWVG- 90 + + L A G+ L +AP EG +QT V + W Sbjct: 229 HSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWV-PLQTFTQHQGAVKAVAWCPW 287 Query: 91 ERGILV---ASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGS--K 145 + +L + + +W + L H V ++ + +SG Sbjct: 288 QSNVLATGGGTSDRHIRIWNVCSGACL----SAVDAHS-QVCSILWSPHYKELISGHGFA 342 Query: 146 DICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQ 205 + +W ++ + H ++V + SP + S + D + LW PA + Sbjct: 343 QNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPD-GATVASAAADETLRLWRCFELDPARR 401 >4A11-B nrPDB Length = 408 Score = 118 bits (295), Expect = 4e-27, Method: Composition-based stats. Identities = 50/230 (21%), Positives = 77/230 (33%), Gaps = 33/230 (14%) Query: 124 HDDIVSTVSVLS-SGTQAVSGSKDICIKVWDLAQQVVLSSYR-------------AHAAQ 169 H ++T+ + G +SG D I ++DL S Y H Sbjct: 42 HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYS 101 Query: 170 VTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFV 229 V V PH +F S S D + +WDT + A Y + + Sbjct: 102 VETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHC-LVA 160 Query: 230 FGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSL-- 287 G V L D KS SC H Q + + +SP LA+ S D + + D Sbjct: 161 VGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRAS 220 Query: 288 -----------SELFRSQ----AHRDFVRDATWSPLNHSLLTTVGWDHQV 322 + + AH V ++ + L TVG D+++ Sbjct: 221 GCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTS-DGLHLLTVGTDNRM 269 Score = 94.4 bits (233), Expect = 6e-20, Method: Composition-based stats. Identities = 48/284 (16%), Positives = 95/284 (33%), Gaps = 48/284 (16%) Query: 83 VADLTWVGER--GILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQA 140 V + W +S +++W+ + +T V F + + +S V + Sbjct: 102 VETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPV--STKHCLV 159 Query: 141 VSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTR-- 198 G++ +++ DL + H ++ V+ SP D + + S D+R+ LWD R Sbjct: 160 AVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRA 219 Query: 199 ------------CPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTS 246 A + +A L + + G + + L ++ + Sbjct: 220 SGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGT-DNRMRLWNSSNGE 278 Query: 247 CVLS--------------SAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLD-SSLSELF 291 L V C + VF P+ ++AV S ++ Sbjct: 279 NTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGS----------TIAVYTVYSGEQIT 328 Query: 292 RSQAHRDFVRDATWSPLNHSLLTTVGWDHQVVHHVVPT--EPLP 333 + H V + N L + D ++ VP+ EP+P Sbjct: 329 MLKGHYKTVDCCVFQS-NFQELYSGSRDCNILAW-VPSLYEPVP 370 Score = 92.9 bits (229), Expect = 2e-19, Method: Composition-based stats. Identities = 32/177 (18%), Positives = 56/177 (31%), Gaps = 25/177 (14%) Query: 166 HAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSA-----------PGYL 214 H + + P + LS D I+L+D S C A Y Sbjct: 42 HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYS 101 Query: 215 PTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCV-------LSSAVHSQCVTGLVFSPHS 267 ++ W+P + +F + T+ + DT + + H V+ Sbjct: 102 VETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVS------TK 155 Query: 268 VPFLASLSEDCSLAVLDSSLSELFRS-QAHRDFVRDATWSPLNHSLLTTVGWDHQVV 323 +A + + + D Q HR + +WSP +L T D +V Sbjct: 156 HCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVK 212 Score = 57.4 bits (137), Expect = 9e-09, Method: Composition-based stats. Identities = 25/189 (13%), Positives = 52/189 (27%), Gaps = 63/189 (33%) Query: 69 NEGFCSAGVQTEAG-VADLTWVG--ERGILVASDSGAVELWELDE------------NET 113 G CS +Q + ++W + + AS V+LW++ + Sbjct: 174 KSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKK 233 Query: 114 LIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWD-------------------- 153 + H+ V+ + S G ++ D +++W+ Sbjct: 234 SQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKK 293 Query: 154 ---------------------------LAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSC 186 + ++ + H V C + ++ S Sbjct: 294 GLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELY-SG 352 Query: 187 SEDNRILLW 195 S D IL W Sbjct: 353 SRDCNILAW 361 >5G04-R nrPDB Length = 499 Score = 117 bits (294), Expect = 5e-27, Method: Composition-based stats. Identities = 40/239 (16%), Positives = 81/239 (33%), Gaps = 16/239 (6%) Query: 77 VQTEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSS 136 ++ + + + W +L + +V LW + L + + + +S+V+ + Sbjct: 181 IRNDYYLNLVDWSS-GNVLAVALDNSVYLWSASSGDILQLLQMEQPGE--YISSVAWIKE 237 Query: 137 GTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWD 196 G G+ +++WD+ QQ L + +H+A+V ++ + + S S I D Sbjct: 238 GNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWN---SYILSSGSRSGHIHHHD 294 Query: 197 TRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTS----CVLSSA 252 R S L W P G + V++ + + + Sbjct: 295 VRV-AEHHVATLSGHSQEVCGLRWAP-DGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFT 352 Query: 253 VHSQCVTGLVFSPHSVPFLASLS--EDCSLAVLDSSLSELFR-SQAHRDFVRDATWSPL 308 H V + + P LA+ D + + + AH WSP Sbjct: 353 QHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCS-ILWSPH 410 Score = 106 bits (265), Expect = 1e-23, Method: Composition-based stats. Identities = 43/210 (20%), Positives = 72/210 (34%), Gaps = 15/210 (7%) Query: 81 AGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQA 140 A V L+W + S SG + ++ E + + H V + G Sbjct: 269 ARVGSLSW-NSYILSSGSRSGHIHHHDVRVAEHHVAT---LSGHSQEVCGLRWAPDGRHL 324 Query: 141 VSGSKDICIKVWDLAQQV----VLSSYRAHAAQVTCVAASPHKDSVFLSCS--EDNRILL 194 SG D + VW A L ++ H V VA P + +V + D I + Sbjct: 325 ASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRI 384 Query: 195 WDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVF-GDENGTVSLVDTKSTSCVLSSAV 253 W+ S + + S+ W P E+ G + + + + V Sbjct: 385 WNVCSGACLSAVDAHSQ---VCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKG 441 Query: 254 HSQCVTGLVFSPHSVPFLASLSEDCSLAVL 283 H+ V L SP +AS + D +L + Sbjct: 442 HTSRVLSLTMSPDGAT-VASAAADETLRLW 470 Score = 86.7 bits (213), Expect = 1e-17, Method: Composition-based stats. Identities = 43/203 (21%), Positives = 79/203 (38%), Gaps = 17/203 (8%) Query: 123 EHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHA--AQVTCVAASPHKD 180 +D ++ V S AV + D + +W + +L + ++ VA + Sbjct: 182 RNDYYLNLVDWSSGNVLAV--ALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGN 239 Query: 181 SVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLV 240 + + S + LWD + K + ++ SL+W+ S + G +G + Sbjct: 240 YLAVGTSS-AEVQLWDVQQQKRLRNM--TSHSARVGSLSWN---SYILSSGSRSGHIHHH 293 Query: 241 DTK-STSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVL-----DSSLSELFRSQ 294 D + + V + + HSQ V GL ++P LAS D + V + L Sbjct: 294 DVRVAEHHVATLSGHSQEVCGLRWAPDG-RHLASGGNDNLVNVWPSAPGEGGWVPLQTFT 352 Query: 295 AHRDFVRDATWSPLNHSLLTTVG 317 H+ V+ W P ++L T G Sbjct: 353 QHQGAVKAVAWCPWQSNVLATGG 375 Score = 58.6 bits (140), Expect = 4e-09, Method: Composition-based stats. Identities = 30/180 (16%), Positives = 58/180 (32%), Gaps = 17/180 (9%) Query: 36 YRSDGALLLGASSLSGRCWAGSLWLFKDPCAAPNEGFCSAGVQTEAG----VADLTWVG- 90 + + L A G+ L +AP EG +QT V + W Sbjct: 308 HSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWV-PLQTFTQHQGAVKAVAWCPW 366 Query: 91 ERGILV---ASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGS--K 145 + +L + + +W + L H V ++ + +SG Sbjct: 367 QSNVLATGGGTSDRHIRIWNVCSGACL----SAVDAHS-QVCSILWSPHYKELISGHGFA 421 Query: 146 DICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQ 205 + +W ++ + H ++V + SP + S + D + LW PA + Sbjct: 422 QNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPD-GATVASAAADETLRLWRCFELDPARR 480 >3W15-A nrPDB Length = 368 Score = 117 bits (294), Expect = 5e-27, Method: Composition-based stats. Identities = 61/299 (20%), Positives = 103/299 (34%), Gaps = 63/299 (21%) Query: 85 DLTW--VGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQ-AV 141 DL W E +LVA G + L++ E I EH+ V + + Q + Sbjct: 67 DLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIA---IFKEHEREVFSCNWNLVNRQNFL 123 Query: 142 SGSKDICIKVWDLAQQVVL------------------------SSYRAHAAQVTCV---A 174 S S D IK+W ++ L S+ + CV Sbjct: 124 SSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQ 183 Query: 175 ASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAP-GYLPTSLAWHPQQSEVFVFGDE 233 SPH ++ LSCS ++ L+D R P +Q G + ++ + V G Sbjct: 184 FSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGV 243 Query: 234 NGTVSLVDTK----------STSCVLSSA-VHSQCVTGLVFSPHSVPFLASLSEDCSLAV 282 + + + D + ++SC+ H + + +SPH L S S D + + Sbjct: 244 DNAIRIWDIRMLNKNPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRI 303 Query: 283 L-----------------DSSLSELFRSQAHRDFVRDATWSPLNHS-LLTTVGWDHQVV 323 D++ +F H +FV A WS + + WD + Sbjct: 304 WRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLF 362 Score = 98.7 bits (244), Expect = 3e-21, Method: Composition-based stats. Identities = 49/279 (17%), Positives = 97/279 (34%), Gaps = 47/279 (16%) Query: 91 ERGILVASDS-----GAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSG-TQAVSGS 144 + + VA+ S G +L+ L+ + + + + + D + ++ S Q + Sbjct: 23 DNRLAVAAGSNFGLVGNGKLFILEIDRSGRIVEVNSFLTQDCLFDLAWNESHENQVLVAQ 82 Query: 145 KDICIKVWDLAQQV-VLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWD------- 196 D ++++D + ++ ++ H +V + FLS S D I +W Sbjct: 83 GDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSL 142 Query: 197 -TRCPKPASQ-----------------IGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVS 238 T P+P G S + P + + N S Sbjct: 143 MTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYAS 202 Query: 239 LVDTK--STSCVLSSAVHSQ-CVTGLVFSPHSVPFLASLSEDCSLAVLDSSL-----SEL 290 L D + S + VHS F+ + +A+ D ++ + D + +L Sbjct: 203 LFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNPGQL 262 Query: 291 FRS-------QAHRDFVRDATWSPLNHSLLTTVGWDHQV 322 S AH +R TWSP + ++L + +D Sbjct: 263 HNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTC 301 Score = 49.4 bits (116), Expect = 2e-06, Method: Composition-based stats. Identities = 20/131 (15%), Positives = 46/131 (35%), Gaps = 11/131 (8%) Query: 204 SQIGCSAPGYLPTSLAWHPQQSEVFVFGDE-------NGTVSLVDT-KSTSCVLSSAVHS 255 S + G+ + + P NG + +++ +S V ++ + Sbjct: 2 SMLRYHMQGFSGYGVQYSPFFDNRLAVAAGSNFGLVGNGKLFILEIDRSGRIVEVNSFLT 61 Query: 256 Q-CVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSE--LFRSQAHRDFVRDATWSPLNHSL 312 Q C+ L ++ + D +L + D++ E + + H V W+ +N Sbjct: 62 QDCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQN 121 Query: 313 LTTVGWDHQVV 323 + WD + Sbjct: 122 FLSSSWDGSIK 132 Score = 48.6 bits (114), Expect = 4e-06, Method: Composition-based stats. Identities = 21/128 (16%), Positives = 44/128 (34%), Gaps = 25/128 (19%) Query: 94 ILVASDSGAVELWELD---ENETLIVSKFCKYE----HDDIVSTVSVLSSGTQAV-SGSK 145 + A+ +W++ +N + + C E H + V+ + + S S Sbjct: 238 VATGGVDNAIRIWDIRMLNKNPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASY 297 Query: 146 DICIKVW-DLAQQVVLSSYRA---------------HAAQVTCVAASP-HKDSVFLSCSE 188 D+ ++W DL+ +Y+ H+ V S K S + Sbjct: 298 DMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAW 357 Query: 189 DNRILLWD 196 D + +W+ Sbjct: 358 DGNLFVWN 365 >5LCW-Q nrPDB Length = 374 Score = 117 bits (294), Expect = 6e-27, Method: Composition-based stats. Identities = 40/239 (16%), Positives = 81/239 (33%), Gaps = 16/239 (6%) Query: 77 VQTEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSS 136 ++ + + + W +L + +V LW + L + + + +S+V+ + Sbjct: 56 IRNDYYLNLVDWSS-GNVLAVALDNSVYLWSASSGDILQLLQMEQPGE--YISSVAWIKE 112 Query: 137 GTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWD 196 G G+ +++WD+ QQ L + +H+A+V ++ + + S S I D Sbjct: 113 GNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWN---SYILSSGSRSGHIHHHD 169 Query: 197 TRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTS----CVLSSA 252 R S L W P G + V++ + + + Sbjct: 170 VRV-AEHHVATLSGHSQEVCGLRWAP-DGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFT 227 Query: 253 VHSQCVTGLVFSPHSVPFLASLS--EDCSLAVLDSSLSELFR-SQAHRDFVRDATWSPL 308 H V + + P LA+ D + + + AH WSP Sbjct: 228 QHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCS-ILWSPH 285 Score = 106 bits (264), Expect = 1e-23, Method: Composition-based stats. Identities = 43/210 (20%), Positives = 72/210 (34%), Gaps = 15/210 (7%) Query: 81 AGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQA 140 A V L+W + S SG + ++ E + + H V + G Sbjct: 144 ARVGSLSW-NSYILSSGSRSGHIHHHDVRVAEHHVAT---LSGHSQEVCGLRWAPDGRHL 199 Query: 141 VSGSKDICIKVWDLAQQV----VLSSYRAHAAQVTCVAASPHKDSVFLSCS--EDNRILL 194 SG D + VW A L ++ H V VA P + +V + D I + Sbjct: 200 ASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRI 259 Query: 195 WDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVF-GDENGTVSLVDTKSTSCVLSSAV 253 W+ S + + S+ W P E+ G + + + + V Sbjct: 260 WNVCSGACLSAVDAHSQ---VCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKG 316 Query: 254 HSQCVTGLVFSPHSVPFLASLSEDCSLAVL 283 H+ V L SP +AS + D +L + Sbjct: 317 HTSRVLSLTMSPDGAT-VASAAADETLRLW 345 Score = 86.7 bits (213), Expect = 1e-17, Method: Composition-based stats. Identities = 43/203 (21%), Positives = 79/203 (38%), Gaps = 17/203 (8%) Query: 123 EHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHA--AQVTCVAASPHKD 180 +D ++ V S AV + D + +W + +L + ++ VA + Sbjct: 57 RNDYYLNLVDWSSGNVLAV--ALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGN 114 Query: 181 SVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLV 240 + + S + LWD + K + ++ SL+W+ S + G +G + Sbjct: 115 YLAVGTSS-AEVQLWDVQQQKRLRNM--TSHSARVGSLSWN---SYILSSGSRSGHIHHH 168 Query: 241 DTK-STSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVL-----DSSLSELFRSQ 294 D + + V + + HSQ V GL ++P LAS D + V + L Sbjct: 169 DVRVAEHHVATLSGHSQEVCGLRWAPDG-RHLASGGNDNLVNVWPSAPGEGGWVPLQTFT 227 Query: 295 AHRDFVRDATWSPLNHSLLTTVG 317 H+ V+ W P ++L T G Sbjct: 228 QHQGAVKAVAWCPWQSNVLATGG 250 Score = 58.2 bits (139), Expect = 4e-09, Method: Composition-based stats. Identities = 30/180 (16%), Positives = 58/180 (32%), Gaps = 17/180 (9%) Query: 36 YRSDGALLLGASSLSGRCWAGSLWLFKDPCAAPNEGFCSAGVQTEAG----VADLTWVG- 90 + + L A G+ L +AP EG +QT V + W Sbjct: 183 HSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWV-PLQTFTQHQGAVKAVAWCPW 241 Query: 91 ERGILV---ASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGS--K 145 + +L + + +W + L H V ++ + +SG Sbjct: 242 QSNVLATGGGTSDRHIRIWNVCSGACL----SAVDAHS-QVCSILWSPHYKELISGHGFA 296 Query: 146 DICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQ 205 + +W ++ + H ++V + SP + S + D + LW PA + Sbjct: 297 QNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPD-GATVASAAADETLRLWRCFELDPARR 355 >5WBU-D nrPDB Length = 328 Score = 117 bits (292), Expect = 1e-26, Method: Composition-based stats. Identities = 46/270 (17%), Positives = 97/270 (35%), Gaps = 29/270 (10%) Query: 71 GFCSAGVQ-TEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVS 129 G C+ VQ ++ V L +R ++ A+ + +++L+ N + + + ++ Sbjct: 34 GICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLNSNNPNPIISYD--GVNKNIA 91 Query: 130 TVSVLSSGTQAVSGSKDICIKVWDLAQQ--VVLSSYRAHAAQVTCVAASPHKDSVFLSCS 187 +V G +G +D ++WDL + ++ A + CV P++ + + Sbjct: 92 SVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQV-NAPINCVCLHPNQAELIV-GD 149 Query: 188 EDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKST-- 245 + I +WD + I P TS P S + + G + + Sbjct: 150 QSGAIHIWDLKTDHNEQLI--PEPEVSITSAHIDPDASYMAAV-NSTGNCYVWNLTGGIG 206 Query: 246 ------SCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRS------ 293 H++ FSP S LA+ S D + + +S L Sbjct: 207 DEVTQLIPKTKIPAHTRYALQCRFSPDST-LLATCSADQTCKIWRTSNFSLMTELSIKSG 265 Query: 294 ---QAHRDFVRDATWSPLNHSLLTTVGWDH 320 ++ R ++ +S + + T D+ Sbjct: 266 NPGESSRGWMWGCAFS-GDSQYIVTASSDN 294 Score = 81.7 bits (200), Expect = 4e-16, Method: Composition-based stats. Identities = 34/208 (16%), Positives = 67/208 (32%), Gaps = 23/208 (11%) Query: 73 CSAGVQTEAGVADLTWVGER-GILVASDSGAVELWELDE--NETLIVSKFCKYEHDDIVS 129 C Q A + + + ++V SGA+ +W+L NE LI ++ Sbjct: 123 CQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEV------SIT 176 Query: 130 TVSVLSSGTQAVSGSKDICIKVWDLAQQV--------VLSSYRAHAAQVTCVAASPHKDS 181 + + + + + VW+L + + AH SP + Sbjct: 177 SAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPD-ST 235 Query: 182 VFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAW-----HPQQSEVFVFGDENGT 236 + +CS D +W T +++ + +S W S+ V + Sbjct: 236 LLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNL 295 Query: 237 VSLVDTKSTSCVLSSAVHSQCVTGLVFS 264 L ++ H + V L F+ Sbjct: 296 ARLWCVETGEIKREYGGHQKAVVCLAFN 323 Score = 79.0 bits (193), Expect = 3e-15, Method: Composition-based stats. Identities = 35/237 (14%), Positives = 70/237 (29%), Gaps = 59/237 (24%) Query: 140 AVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPH--------------------- 178 + D ++ W + + + +QV + +P Sbjct: 17 LATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLNSNN 76 Query: 179 ---------------------KDSVFLSCSEDNRILLWDT--RCPKPASQIGCSAPGYLP 215 + ED +WD R + +AP Sbjct: 77 PNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAP---I 133 Query: 216 TSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLS 275 + HP Q+E+ V GD++G + + D K+ +T P + ++A+++ Sbjct: 134 NCVCLHPNQAELIV-GDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDA-SYMAAVN 191 Query: 276 EDCSLAVLDS---------SLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQVV 323 + V + L + AH + +SP + +LL T D Sbjct: 192 STGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSP-DSTLLATCSADQTCK 247 Score = 65.9 bits (159), Expect = 3e-11, Method: Composition-based stats. Identities = 13/115 (11%), Positives = 40/115 (34%), Gaps = 3/115 (2%) Query: 178 HKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTV 237 + + D+ + W + +L P +S + G ++ + Sbjct: 12 SDPVILATAGYDHTVRFWQAHSGICTRTVQH--QDSQVNALEVTPDRSMIAAAGYQHIRM 69 Query: 238 SLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFR 292 +++ + + ++S ++ + + F ++ + EDC+ + D L Sbjct: 70 YDLNSNNPNPIISYDGVNKNIASVGFHEDG-RWMYTGGEDCTARIWDLRSRNLQC 123 >5OQL-J nrPDB Length = 912 Score = 115 bits (289), Expect = 2e-26, Method: Composition-based stats. Identities = 53/293 (18%), Positives = 93/293 (31%), Gaps = 51/293 (17%) Query: 77 VQTEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSS 136 + D+ V + S+ A E H+DIV ++ V S Sbjct: 389 MAIATNSEDIRIVSVKDAQAYSEDNA----ECRSGSYFGHDVALLKGHEDIVMSLDVDWS 444 Query: 137 GTQAVSGSKDICIKVWDL----AQQVVLSSYRAHAAQVTCVAA-------------SP-- 177 G SGSKD ++W + + + H V VA +P Sbjct: 445 GHWIASGSKDNTARLWRVDPANNSYTCYAVFTGHLESVGAVALPKVVPPANSEAFKNPLD 504 Query: 178 HKDSVFLSCSEDNRILLWDT-----RCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGD 232 H + +S S+D + D + K S + A +L P ++F Sbjct: 505 HPPAFLISGSQDRFVQKRDIPRQLQKGGKLTSSLRRLAHDKDINALDISPN-GKLFASAS 563 Query: 233 ENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFL-------------ASLSEDCS 279 ++ TV + D + H + V + F+P + P + + S D + Sbjct: 564 QDKTVKIWDVEKLEVQGILRGHKRGVWTVRFAPLNTPVIQGEQGSVSGRGVVLTGSGDKT 623 Query: 280 LAVLDSSLSELFR-SQAHRDFVRDATW--SPLNHSL------LTTVGWDHQVV 323 + + + S R + H V W + S+ + G D V Sbjct: 624 IKLWNLSDYTCIRTFEGHSHNVLKVVWLHISRDDSITKTKVQFASAGADTLVK 676 Score = 111 bits (278), Expect = 4e-25, Method: Composition-based stats. Identities = 36/218 (16%), Positives = 66/218 (30%), Gaps = 27/218 (12%) Query: 90 GERGILVASDSGAVELWEL---DENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKD 146 ++ S V+ ++ + + S + HD ++ + + +G S S+D Sbjct: 506 PPAFLISGSQDRFVQKRDIPRQLQKGGKLTSSLRRLAHDKDINALDISPNGKLFASASQD 565 Query: 147 ICIKVWDLAQQVVLSSYRAHAAQVTCVAASP-------------HKDSVFLSCSEDNRIL 193 +K+WD+ + V R H V V +P V L+ S D I Sbjct: 566 KTVKIWDVEKLEVQGILRGHKRGVWTVRFAPLNTPVIQGEQGSVSGRGVVLTGSGDKTIK 625 Query: 194 LWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSE--------VFVFGDENGTVSLVDTKST 245 LW+ + L + W + F + V + D + Sbjct: 626 LWNLSDYTCIRTFEGHSHNVLK--VVWLHISRDDSITKTKVQFASAGADTLVKVWDANTG 683 Query: 246 SCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVL 283 + H + L LAS D + Sbjct: 684 ETECTLDNHEDRLWTLAVH-SKTNILASAGSDSKVTFW 720 Score = 78.6 bits (192), Expect = 3e-15, Method: Composition-based stats. Identities = 49/306 (16%), Positives = 103/306 (33%), Gaps = 49/306 (16%) Query: 69 NEGFCSAGVQTEAG-VADLTWVGE-RGILVASDSGAVELW------ELDENETLIVSKFC 120 N G A +Q + ++ LT ++V S S + ++ + D E +V Sbjct: 49 NTGKRLAEIQGDGEPISTLTITPSGSHLIVCSRSLTMRIYSLAISPDYDSVEPTLVRTTK 108 Query: 121 KYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAA----- 175 H V ++V + T +G+ D IK+WD+ V + + V+ + Sbjct: 109 P--HATPVVVLAVDRTSTLLATGAADGAIKIWDIIGGYVTHTVSGPSVLVSALHFFEIAV 166 Query: 176 -------------------SPHKDSV-----FLSCSEDNRILLWDTRCPKPASQIGCS-- 209 + D + ++D RI ++D Sbjct: 167 TAESQSSNKKPKKGSRKGQNDDADEIASRFRLAWGTQDGRIRIFDLYKRTTTPVYADPKR 226 Query: 210 ---APGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPH 266 A +A+ P+Q + G + T++L + + + + + + F + Sbjct: 227 KKEAHESNVQCIAYSPEQ-HALLSGSRDKTMTLWLWRDGIWQGTPMLRHELLESVGFL-N 284 Query: 267 SVPFLASLSEDCSLAVLDSSL-SELFRSQAHRDFVRDA--TWSPLNHSLLTTVGWDHQVV 323 ++ S L + D++ E+ + Q + S SL+ D +V Sbjct: 285 EGKWMYSAGTSGVLRIWDTTTHHEITKKQDAKSEGEAILSAVSLPERSLILCAQADFTLV 344 Query: 324 HHVVPT 329 + VP+ Sbjct: 345 LYRVPS 350 Score = 73.2 bits (178), Expect = 2e-13, Method: Composition-based stats. Identities = 43/301 (14%), Positives = 91/301 (30%), Gaps = 58/301 (19%) Query: 62 KDPCAAPNEGFCSAGVQTEAGVADLTWVGERGILVASDSGAVELWELDENETLIV---SK 118 K P +G + + L W + G + +++L + T V K Sbjct: 175 KKPKKGSRKGQNDDADEIASRF-RLAW--------GTQDGRIRIFDLYKRTTTPVYADPK 225 Query: 119 FCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSS-YRAHA--AQVTCVAA 175 K H+ V ++ +SGS+D + +W + + H V + Sbjct: 226 RKKEAHESNVQCIAYSPEQHALLSGSRDKTMTLWLWRDGIWQGTPMLRHELLESVGFL-- 283 Query: 176 SPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENG 235 ++ S + +WDT ++ + A + + + + Sbjct: 284 --NEGKWMYSAGTSGVLRIWDTTTHHEITKKQDAKSEGEAILSAVSLPERSLILCAQADF 341 Query: 236 TVSLV------DTKSTS------CVLSSAVHSQCVTGLVF--SPHSVPFLASLSEDCSLA 281 T+ L D S+S + + L + S+ +A+ SED + Sbjct: 342 TLVLYRVPSPADVVSSSEGILLEPFRRISGTHDEILDLTYILPDQSMMAIATNSED--IR 399 Query: 282 VLDSSLSELFR------------------SQAHRDFVR--DATWSPLNHSLLTTVGWDHQ 321 ++ ++ + + H D V D WS + + D+ Sbjct: 400 IVSVKDAQAYSEDNAECRSGSYFGHDVALLKGHEDIVMSLDVDWS---GHWIASGSKDNT 456 Query: 322 V 322 Sbjct: 457 A 457 >6BX3-A nrPDB Length = 314 Score = 115 bits (288), Expect = 3e-26, Method: Composition-based stats. Identities = 43/225 (19%), Positives = 77/225 (34%), Gaps = 20/225 (8%) Query: 84 ADLTWVGE-RGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVS 142 ++L W + + I ASD +VE+ L H V +++ G + Sbjct: 58 SELCWSPDGQCIATASDDFSVEIIHL-----SYGLLHTFIGHTAPVISLTFNRKGNLLFT 112 Query: 143 GSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKP 202 S D IK+WD ++ + AH+ V V + S+ S S D I ++D Sbjct: 113 SSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHC 172 Query: 203 ASQIGCS-----APGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSS------ 251 + G +P S + + + +G V + D V + Sbjct: 173 LKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLE 232 Query: 252 AVHSQCVTGLVF-SPHSV--PFLASLSEDCSLAVLDSSLSELFRS 293 G+ F +P P + S E+ + +S L + Sbjct: 233 KGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQL 277 Score = 109 bits (271), Expect = 2e-24, Method: Composition-based stats. Identities = 34/217 (15%), Positives = 77/217 (35%), Gaps = 16/217 (7%) Query: 76 GVQTEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLS 135 G Q + L + + +++++ VS+ H S + Sbjct: 8 GTQNGLKATCAKISPDGQFLAITQGLNILIYDINRRT---VSQTLVTSHARPFSELCWSP 64 Query: 136 SGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLW 195 G + S D +++ L+ +L ++ H A V + + K ++ + S D I +W Sbjct: 65 DGQCIATASDDFSVEIIHLSYG-LLHTFIGHTAPVISLTFN-RKGNLLFTSSMDESIKIW 122 Query: 196 DTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHS 255 DT I + + + + S + G +G + + D ++ C+ + Sbjct: 123 DTLNGSLMKTISAHSEAVVSVDVPMN--DSSILSSGSYDGLIRIFDAETGHCLKTLTYDK 180 Query: 256 QC--------VTGLVFSPHSVPFLASLSEDCSLAVLD 284 ++ + FS ++ L S D + + D Sbjct: 181 DWKRENGVVPISQVKFSENARYLLVK-SLDGVVKIWD 216 Score = 64.4 bits (155), Expect = 7e-11, Method: Composition-based stats. Identities = 25/170 (14%), Positives = 56/170 (32%), Gaps = 16/170 (9%) Query: 85 DLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDI----VSTVSVLSSGTQA 140 D+ + S G + +++ + L + K + +S V + Sbjct: 144 DVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYL 203 Query: 141 VSGSKDICIKVWDLAQQVVLSSYRA--------HAAQVTCVAASPHKDS--VFLSCSEDN 190 + S D +K+WD V+ +++ H + +P S + +S E+ Sbjct: 204 LVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDF-LNPEDGSTPLVISGYENG 262 Query: 191 RILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLV 240 I W++ + S + ++ H + + NG L Sbjct: 263 DIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGN-IMCSLALNGDCCLW 311 Score = 47.4 bits (111), Expect = 1e-05, Method: Composition-based stats. Identities = 22/113 (19%), Positives = 42/113 (37%), Gaps = 5/113 (4%) Query: 212 GYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSS-AVHSQCVTGLVFSPHSVPF 270 G T P + + N + + D + + H++ + L +SP Sbjct: 12 GLKATCAKISPDGQFLAITQGLN--ILIYDINRRTVSQTLVTSHARPFSELCWSPDGQC- 68 Query: 271 LASLSEDCSLAVLDSSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQVV 323 +A+ S+D S+ ++ S L H V T++ +LL T D + Sbjct: 69 IATASDDFSVEIIHLSYGLLHTFIGHTAPVISLTFN-RKGNLLFTSSMDESIK 120 >5WLC-LN nrPDB Length = 776 Score = 115 bits (287), Expect = 3e-26, Method: Composition-based stats. Identities = 55/275 (20%), Positives = 94/275 (34%), Gaps = 44/275 (16%) Query: 49 LSGRCWAGSLWLFKDPCAAPNEGFC---SAGVQTEAGVADLTWVGERGILVASDSGAVEL 105 LS C G++ + D P G + ++ EA V L W + ++ G + + Sbjct: 156 LSVGCDNGTV-VLIDISGGP--GVLEHDTILMRQEARVLTLAWKKDDFVIGGCSDGRIRI 212 Query: 106 WELDENE--------TLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQ 157 W +N+ T+ V K K +V +V L Q SG IK WD Sbjct: 213 WSAQKNDENMGRLLHTMKVDKAKK--ESTLVWSVIYLPRTDQIASGDSTGSIKFWDFQFA 270 Query: 158 VVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPAS-------QIGCSA 210 + S++AH A V C+ + VF S D +I + K Sbjct: 271 TLNQSFKAHDADVLCLTTDTDNNYVF-SAGVDRKIFQFSQNTNKSQKNNRWVNSSNRLLH 329 Query: 211 PGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTS--------CVLSSAVHSQCVTGLV 262 + A+ + ++ V G T+ + S S V + + V Sbjct: 330 GNDIRAICAYQSKGADFLVSGGVEKTLVINSLTSFSNGNYRKMPTVEPYSKNV-LVNK-- 386 Query: 263 FSPHSVPFLASLSEDCSLAVL----DSSLSELFRS 293 + S SE ++ + DSS + ++ Sbjct: 387 ----EQRLVVSWSE-STVKIWTMGTDSSTEQNYKL 416 Score = 77.5 bits (189), Expect = 7e-15, Method: Composition-based stats. Identities = 36/248 (14%), Positives = 91/248 (36%), Gaps = 15/248 (6%) Query: 90 GERGILVASDSGAVELWELDEN--ETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDI 147 + + + +G +E+W N + +++ + + + +V + S Sbjct: 63 SDLRLAIGRSNGNIEIWNPRNNWFQEMVIEGGKDRSIEGLCWS-NVNGESLRLFSIGGST 121 Query: 148 CIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIG 207 + WDLA + L +Y ++ + ++ + +D + + ++ ++L D + Sbjct: 122 VVTEWDLATGLPLRNYDCNSGVIWSISINDSQDKLSV-GCDNGTVVLIDISGGPGVLEHD 180 Query: 208 CSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCV------TGL 261 L ++ + + G +G + + + + +H+ V + L Sbjct: 181 TILMRQEARVLTLAWKKDDFVIGGCSDGRIRIWSAQKNDENMGRLLHTMKVDKAKKESTL 240 Query: 262 VFSPHSVP---FLASLSEDCSLAVLDSSLSEL-FRSQAHRDFVRDATWSPLNHSLLTTVG 317 V+S +P +AS S+ D + L +AH V T N+ + + G Sbjct: 241 VWSVIYLPRTDQIASGDSTGSIKFWDFQFATLNQSFKAHDADVLCLTTDTDNNYVF-SAG 299 Query: 318 WDHQVVHH 325 D ++ Sbjct: 300 VDRKIFQF 307 >4N14-A nrPDB Length = 314 Score = 115 bits (287), Expect = 3e-26, Method: Composition-based stats. Identities = 40/239 (16%), Positives = 81/239 (33%), Gaps = 16/239 (6%) Query: 77 VQTEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSS 136 ++ + + + W +L + +V LW + L + + + +S+V+ + Sbjct: 18 IRNDYYLNLVDWSS-GNVLAVALDNSVYLWSASSGDILQLLQMEQPGE--YISSVAWIKE 74 Query: 137 GTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWD 196 G G+ +++WD+ QQ L + +H+A+V ++ + + S S I D Sbjct: 75 GNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWN---SYILSSGSRSGHIHHHD 131 Query: 197 TRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTS----CVLSSA 252 R S L W P G + V++ + + + Sbjct: 132 VRV-AEHHVATLSGHSQEVCGLRWAP-DGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFT 189 Query: 253 VHSQCVTGLVFSPHSVPFLASLS--EDCSLAVLDSSLSELFR-SQAHRDFVRDATWSPL 308 H V + + P LA+ D + + + AH WSP Sbjct: 190 QHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCS-ILWSPH 247 Score = 104 bits (259), Expect = 7e-23, Method: Composition-based stats. Identities = 43/210 (20%), Positives = 72/210 (34%), Gaps = 15/210 (7%) Query: 81 AGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQA 140 A V L+W + S SG + ++ E + + H V + G Sbjct: 106 ARVGSLSW-NSYILSSGSRSGHIHHHDVRVAEHHVAT---LSGHSQEVCGLRWAPDGRHL 161 Query: 141 VSGSKDICIKVWDLAQQV----VLSSYRAHAAQVTCVAASPHKDSVFLSCS--EDNRILL 194 SG D + VW A L ++ H V VA P + +V + D I + Sbjct: 162 ASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRI 221 Query: 195 WDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVF-GDENGTVSLVDTKSTSCVLSSAV 253 W+ S + + S+ W P E+ G + + + + V Sbjct: 222 WNVCSGACLSAVDAHSQ---VCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKG 278 Query: 254 HSQCVTGLVFSPHSVPFLASLSEDCSLAVL 283 H+ V L SP +AS + D +L + Sbjct: 279 HTSRVLSLTMSPDGAT-VASAAADETLRLW 307 Score = 84.4 bits (207), Expect = 6e-17, Method: Composition-based stats. Identities = 43/203 (21%), Positives = 79/203 (38%), Gaps = 17/203 (8%) Query: 123 EHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHA--AQVTCVAASPHKD 180 +D ++ V S AV + D + +W + +L + ++ VA + Sbjct: 19 RNDYYLNLVDWSSGNVLAV--ALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGN 76 Query: 181 SVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLV 240 + + S + LWD + K + ++ SL+W+ S + G +G + Sbjct: 77 YLAVGTSS-AEVQLWDVQQQKRLRNM--TSHSARVGSLSWN---SYILSSGSRSGHIHHH 130 Query: 241 DTK-STSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVL-----DSSLSELFRSQ 294 D + + V + + HSQ V GL ++P LAS D + V + L Sbjct: 131 DVRVAEHHVATLSGHSQEVCGLRWAPDG-RHLASGGNDNLVNVWPSAPGEGGWVPLQTFT 189 Query: 295 AHRDFVRDATWSPLNHSLLTTVG 317 H+ V+ W P ++L T G Sbjct: 190 QHQGAVKAVAWCPWQSNVLATGG 212 Score = 56.7 bits (135), Expect = 1e-08, Method: Composition-based stats. Identities = 28/170 (16%), Positives = 55/170 (32%), Gaps = 17/170 (10%) Query: 36 YRSDGALLLGASSLSGRCWAGSLWLFKDPCAAPNEGFCSAGVQTEAG----VADLTWVG- 90 + + L A G+ L +AP EG +QT V + W Sbjct: 145 HSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWV-PLQTFTQHQGAVKAVAWCPW 203 Query: 91 ERGILV---ASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGS--K 145 + +L + + +W + L H V ++ + +SG Sbjct: 204 QSNVLATGGGTSDRHIRIWNVCSGACL----SAVDAHS-QVCSILWSPHYKELISGHGFA 258 Query: 146 DICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLW 195 + +W ++ + H ++V + SP + S + D + LW Sbjct: 259 QNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPD-GATVASAAADETLRLW 307 >6E29-D nrPDB Length = 345 Score = 112 bits (279), Expect = 3e-25, Method: Composition-based stats. Identities = 48/255 (18%), Positives = 88/255 (34%), Gaps = 32/255 (12%) Query: 95 LVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDL 154 L+ SD ++ + EN ++ + H + V G SG D + +WDL Sbjct: 4 LLLSDDYLLQ--DYPEN----ITNTIRSGHS---TCVRFNRKGDFLASGRVDGTVVIWDL 54 Query: 155 AQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYL 214 V R H+ +T ++ S LS + +++LWD + K ++ AP Y Sbjct: 55 ETMGVARKLRGHSKNITSLSWS-RCGRYLLSACQGWKVILWDLQDGKRYREVRFRAPVYG 113 Query: 215 PTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSS-------------------AVHS 255 W+ Q +F D+ V + + VL S Sbjct: 114 AELHPWNHHQFAAALFEDQPMLVDITEPVEVRYVLPSVPKRTSTETDPALREKQAKEDAK 173 Query: 256 QCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSE-LFRSQAHRDFVRDATWSPLNHSLLT 314 T +V++ LA + L ++D+ E ++ + + + LL Sbjct: 174 HMTTAIVYTASGDHLLA-GTTKGRLNIIDARTREIIYSEKIASGIITTLRLTESGRELLV 232 Query: 315 TVGWDHQVVHHVVPT 329 D + +VP Sbjct: 233 NA-QDRIIRTFIVPN 246 Score = 57.4 bits (137), Expect = 9e-09, Method: Composition-based stats. Identities = 23/188 (12%), Positives = 59/188 (31%), Gaps = 15/188 (7%) Query: 109 DENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAA 168 E + + K K + + + + +SG ++G+ + + D + ++ S + + Sbjct: 157 TETDPALREKQAKEDAKHMTTAIVYTASGDHLLAGTTKGRLNIIDARTREIIYSEKIASG 216 Query: 169 QVTCVAASPHKDSVFLSCSEDNRILLW--------DTRCPKPASQIGCSAPGYLPTSLAW 220 +T + + + ++ +D I + D P + L+W Sbjct: 217 IITTLRLTESGRELLVNA-QDRIIRTFIVPNLSAADLD-PDTIQLPLEHKFQDVVNRLSW 274 Query: 221 HP-----QQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLS 275 + V N + + + S V + + + PH A Sbjct: 275 NHVAFSATGEYVAASTYNNHELYIWERGHGSLVRMLEGPKEEQGVIEWHPHRALLAACGL 334 Query: 276 EDCSLAVL 283 E + + Sbjct: 335 ETGRINIW 342 Score = 52.8 bits (125), Expect = 2e-07, Method: Composition-based stats. Identities = 23/167 (13%), Positives = 57/167 (34%), Gaps = 22/167 (13%) Query: 92 RGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKV 151 +L + G + + + E + K I++T+ + SG + + ++D I+ Sbjct: 186 DHLLAGTTKGRLNIIDARTREIIYSEKIA----SGIITTLRLTESGRELLVNAQDRIIRT 241 Query: 152 W--------DLAQQVVLSSYRAH--AAQVTCVAAS-----PHKDSVFLSCSEDNRILLWD 196 + DL + H V ++ + + V S ++ + +W+ Sbjct: 242 FIVPNLSAADLDPDTIQLPLE-HKFQDVVNRLSWNHVAFSATGEYVAASTYNNHELYIWE 300 Query: 197 TRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTK 243 + + WHP ++ + G E G +++ Sbjct: 301 RGHGSLVRMLEGPKEEQGV--IEWHPHRALLAACGLETGRINIWSVT 345 >6CHG-A nrPDB Length = 312 Score = 110 bits (276), Expect = 7e-25, Method: Composition-based stats. Identities = 46/255 (18%), Positives = 84/255 (32%), Gaps = 32/255 (12%) Query: 83 VADLTWVGERG-ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAV 141 + L W + I S+ VE+ + H V ++ + G Sbjct: 57 INCLCWSPDSKCIASGSEDFTVEI-----THIIYGRIRRLMGHTAPVISICYNNKGNILC 111 Query: 142 SGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPK 201 S S D IK W + L + AH+ V + S+ S S D I ++DT Sbjct: 112 SSSMDESIKEWHVLSGTALKTMSAHSDAVVSIDIPKFDSSILSSGSYDGLIRIFDTESGH 171 Query: 202 PASQIGCS-----APGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSS-AVHS 255 + G +P S + + + + V L + + V + H Sbjct: 172 CLKTLTYDKDWIAEDGVVPISTVKFSRNGKFLLVKSLDNVVKLWEYTRGTVVRTFLWPHQ 231 Query: 256 QCVTGLVFS-------PHS-VPFLASLSEDCSLAVLDSSLSELFRS--QAHRDFVRDATW 305 + L ++ P P + S ++ S+ V + L + + HR+ Sbjct: 232 ETKAKLKYNCGLELIYPQGKDPLVISGNDSGSMCVWNVYSKNLVQKIDEKHRN------- 284 Query: 306 SPLNHSLLTTVGWDH 320 SPL + + +D Sbjct: 285 SPL---ISISASYDK 296 Score = 102 bits (255), Expect = 2e-22, Method: Composition-based stats. Identities = 36/239 (15%), Positives = 83/239 (34%), Gaps = 26/239 (10%) Query: 63 DPCAAPNEGFCSAGVQTEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKY 122 D P G S Q + ++ + + ++E+ ++ + ++ Sbjct: 5 DKQVLPASGKISTSCQI---------SPDGELIAICQNTDMLVYEISSSKMMKLTTT--- 52 Query: 123 EHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSV 182 H + ++ + SGS+D +++ + + H A V + + +K ++ Sbjct: 53 -HKECINCLCWSPDSKCIASGSEDFTVEITHIIYGR-IRRLMGHTAPVISICYN-NKGNI 109 Query: 183 FLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDT 242 S S D I W + SA S+ S + G +G + + DT Sbjct: 110 LCSSSMDESIKEWHVLSGTALKTM--SAHSDAVVSIDIPKFDSSILSSGSYDGLIRIFDT 167 Query: 243 KSTSCVLSSAVHSQC--------VTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRS 293 +S C+ + ++ + FS + L S D + + + + + R+ Sbjct: 168 ESGHCLKTLTYDKDWIAEDGVVPISTVKFSRNGKFLLVK-SLDNVVKLWEYTRGTVVRT 225 Score = 64.0 bits (154), Expect = 9e-11, Method: Composition-based stats. Identities = 24/120 (20%), Positives = 47/120 (39%), Gaps = 4/120 (3%) Query: 208 CSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHS 267 A G + TS P + + + + V + S+ + + H +C+ L +SP S Sbjct: 9 LPASGKISTSCQISPDGELIAICQNTDMLV--YEISSSKMMKLTTTHKECINCLCWSPDS 66 Query: 268 VPFLASLSEDCSLAVLDSSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQVVHHVV 327 +AS SED ++ + + R H V ++ ++L + D + V Sbjct: 67 -KCIASGSEDFTVEITHIIYGRIRRLMGHTAPVISICYN-NKGNILCSSSMDESIKEWHV 124 >6ELZ-p nrPDB Length = 460 Score = 109 bits (271), Expect = 2e-24, Method: Composition-based stats. Identities = 49/256 (19%), Positives = 88/256 (34%), Gaps = 27/256 (10%) Query: 80 EAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQ 139 +A V + IL AS ++ W E +V + + + +S + + Sbjct: 208 KAPVVSIDVSDNSRILSASYDNSIGFWSTIYKEMTVVDPLEDINNPN--NKISTAARKRR 265 Query: 140 AVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRC 199 ++ KD I+ ++ LS +H A V V ++V S S+D+ I WD Sbjct: 266 KLT-MKDGTIR-----RRAPLSLLESHTAPVEQVIFDSTDNTVGYSVSQDHTIKTWDLVT 319 Query: 200 PKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCV----LSSAVHS 255 A I Y S+A + G ++L D + + H Sbjct: 320 ---ARCIDTRTTSYSLLSIA-QLSTLNLLACGSSARHITLHDPRVGASSKVTQQQLIGHK 375 Query: 256 QCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRS---------QAHRDFVRDATWS 306 V+ L P + L S S D ++ V D + + + D V W+ Sbjct: 376 NFVSSLDTCPENEYILCSGSHDGTVKVWDVRSTSPMYTITREDKSVQKGVNDKVFAVKWA 435 Query: 307 PLNHSLLTTVGWDHQV 322 + + G D ++ Sbjct: 436 --EKVGIISAGQDKKI 449 Score = 84.4 bits (207), Expect = 6e-17, Method: Composition-based stats. Identities = 33/231 (14%), Positives = 73/231 (31%), Gaps = 30/231 (12%) Query: 114 LIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCV 173 L S + ++D VS++ V +SGS D ++ WDL V Y H+ + V Sbjct: 92 LPPSYLNSFSNEDWVSSLDVGDGSKHIISGSYDGIVRTWDL-SGNVQKQYSGHSGPIRAV 150 Query: 174 AASPHKDSVFLSCSEDNRILLWDTRCPKPA-------------------SQIGCSAPGYL 214 + +S D + LW T+ + G+ Sbjct: 151 KYISNTR--LVSAGNDRTLRLWKTKNDDLKLTSQQQAQEDDDDEVNIEDGKTLAILEGHK 208 Query: 215 PTSLAWHPQQSEVFVFGDENGTVSLVD--TKSTSCVLSSAVHSQCVTGLVFSPHSVPFLA 272 ++ + + + ++ K + V + + + L Sbjct: 209 APVVSIDVSDNSRILSASYDNSIGFWSTIYKEMTVVDPLEDINNPNNKISTAARKRRKLT 268 Query: 273 SLSEDCSLAVLDSSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQVV 323 +D ++ + L ++H V + ++++ +V DH + Sbjct: 269 M--KDGTIR----RRAPLSLLESHTAPVEQVIFDSTDNTVGYSVSQDHTIK 313 Score = 67.5 bits (163), Expect = 7e-12, Method: Composition-based stats. Identities = 22/156 (14%), Positives = 47/156 (30%), Gaps = 17/156 (10%) Query: 96 VASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLA 155 S ++ W+L + + +++ LS+ GS I + D Sbjct: 305 SVSQDHTIKTWDLVTARCIDTRTT-----SYSLLSIAQLSTLNLLACGSSARHITLHDPR 359 Query: 156 ----QQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQI----- 206 +V H V+ + P + + S S D + +WD R P I Sbjct: 360 VGASSKVTQQQLIGHKNFVSSLDTCPENEYILCSGSHDGTVKVWDVRSTSPMYTITREDK 419 Query: 207 -GCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVD 241 ++ W + + ++ + + Sbjct: 420 SVQKGVNDKVFAVKWAEKVG--IISAGQDKKIQINK 453 >4J0W-A nrPDB Length = 343 Score = 106 bits (265), Expect = 1e-23, Method: Composition-based stats. Identities = 38/215 (17%), Positives = 73/215 (33%), Gaps = 16/215 (7%) Query: 91 ERGILVASDSGAVELWELDENETLIVSKFCKYE-------HDDIVSTVSVLSSGTQAVSG 143 + I A+ ++ W ++ L V K H V +++ S G SG Sbjct: 26 DSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSHVLCMAISSDGKYLASG 85 Query: 144 SKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPA 203 + I +W+ L ++ H V+ +A S S D + +W+ Sbjct: 86 DRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFR-RGTHQLYSTSHDRSVKVWNVAENSYV 144 Query: 204 SQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVF 263 + +L ++ V G +GTV + S L H + + Sbjct: 145 ETL--FGHQDAVAALDALSRECCVTA-GGRDGTVRVWKIPEESQ-LVFYGHQGSIDCI-- 198 Query: 264 SPHSVPFLASLSEDCSLAVLDSSLSE--LFRSQAH 296 + + S ++D S+A+ S + +AH Sbjct: 199 HLINEEHMVSGADDGSVALWGLSKKRPLALQREAH 233 Score = 91.3 bits (225), Expect = 6e-19, Method: Composition-based stats. Identities = 31/211 (14%), Positives = 62/211 (29%), Gaps = 18/211 (8%) Query: 123 EHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSY-----------RAHAAQVT 171 H ++ + V + S +KD I W + L H++ V Sbjct: 12 GHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSHVL 71 Query: 172 CVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFG 231 C+A S S IL+W + + LA+ +++ Sbjct: 72 CMAISSD-GKYLASGDRSKLILIW--EAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYST- 127 Query: 232 DENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELF 291 + +V + + S V + H V L + + + D ++ V Sbjct: 128 SHDRSVKVWNVAENSYVETLFGHQDAVAALD-ALSRECCVTAGGRDGTVRVWKIPEESQL 186 Query: 292 RSQAHRDFVRDATWSPLNHSLLTTVGWDHQV 322 H+ + +N + + D V Sbjct: 187 VFYGHQGSID--CIHLINEEHMVSGADDGSV 215 Score = 87.5 bits (215), Expect = 7e-18, Method: Composition-based stats. Identities = 37/180 (20%), Positives = 66/180 (36%), Gaps = 12/180 (6%) Query: 160 LSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQI-------GCSAPG 212 + R H +TC+ +P ++F S ++D I+ W + I PG Sbjct: 7 IRVLRGHQLSITCLVVTPDDSAIF-SAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPG 65 Query: 213 YLPTSLAWH-PQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFL 271 + L + GD + + + + +S + + H V+GL F L Sbjct: 66 HSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFR-RGTHQL 124 Query: 272 ASLSEDCSLAVLDSSLSELFRSQ-AHRDFVRDATWSPLNHSLLTTVGWDHQVVHHVVPTE 330 S S D S+ V + + + + H+D V + +T G D V +P E Sbjct: 125 YSTSHDRSVKVWNVAENSYVETLFGHQDAVAALD-ALSRECCVTAGGRDGTVRVWKIPEE 183 Score = 44.7 bits (104), Expect = 6e-05, Method: Composition-based stats. Identities = 20/120 (16%), Positives = 45/120 (37%), Gaps = 10/120 (8%) Query: 86 LTWVGERGILVASDSGAVELWELDENETLIVSKFCK-------YEHDDIVSTVSVLSSGT 138 + + E ++ +D G+V LW L + L + + E +S+V+ L + Sbjct: 198 IHLINEEHMVSGADDGSVALWGLSKKRPLALQREAHGLRGEPGLEQPFWISSVAALLNTD 257 Query: 139 QAVSGSKDICIKVWDLAQQVVLSSY---RAHAAQVTCVAASPHKDSVFLSCSEDNRILLW 195 +GS C+++W + + + S D + +++R+ W Sbjct: 258 LVATGSHSSCVRLWQCGEGFRQLDLLCDIPLVGFINSLKFSSSGDFLVAGVGQEHRLGRW 317 >4PSX-B nrPDB Length = 401 Score = 106 bits (265), Expect = 1e-23, Method: Composition-based stats. Identities = 37/211 (17%), Positives = 81/211 (38%), Gaps = 7/211 (3%) Query: 119 FCKYEHDDIVSTVSVLSSGTQAV-SGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASP 177 KYEH++ ++ + V + + ++ + + S+ + H ++ S Sbjct: 112 TAKYEHEEEITRARYMPQDPNIVATINGQGTTFLYS-RSEGLQSTLKFHKDNGYALSFST 170 Query: 178 HKDSVFLSCSEDNRILLWDT-RCPKPASQIGC--SAPGYLPTSLAWHPQQSEVFVFGDEN 234 LS S+D+ + LW+ P + + WH ++F E+ Sbjct: 171 LVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSED 230 Query: 235 GTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSE--LFR 292 + + D ++ + + + Q L FS HS LA+ D + + D + L Sbjct: 231 SLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHH 290 Query: 293 SQAHRDFVRDATWSPLNHSLLTTVGWDHQVV 323 H D V + +S ++ + G D++++ Sbjct: 291 MSGHEDAVNNLEFSTHVDGVVVSSGSDNRLM 321 Score = 96.3 bits (238), Expect = 2e-20, Method: Composition-based stats. Identities = 52/300 (17%), Positives = 101/300 (33%), Gaps = 30/300 (10%) Query: 67 APNEGF-CSAGVQTEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHD 125 AP +A + E + ++ + +VA+ +G + +E L + H Sbjct: 104 APRSNIRITAKYEHEEEITRARYMPQDPNIVATINGQGTTFLYSRSEGL---QSTLKFHK 160 Query: 126 DIVSTVSVLS-SGTQAVSGSKDICIKVWDLAQQ----VVLSSY-RAHAAQVTCVAASPHK 179 D +S + + +SGS D + +W++ + ++ H+ + Sbjct: 161 DNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFN 220 Query: 180 DSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSL 239 +F + SED+ + + D R + I +LA+ S + + V L Sbjct: 221 KDLFGTVSEDSLLKINDVRANN--TTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYL 278 Query: 240 VDTKS-TSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQ---- 294 D ++ + + H V L FS H + S D L + D ++ Sbjct: 279 YDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAE 338 Query: 295 -----------AHRDFVRDATWSPLNHSLLTTVGWDHQVVHHVVPTEPLP-APGPASVTE 342 HR V D +P L + ++ + LP GP V + Sbjct: 339 DGVPELIMVHAGHRSSVNDFDLNPQ-IPWLVASAEEENILQVWKCSHSLPIVGGPPKVNK 397 Score = 82.5 bits (202), Expect = 3e-16, Method: Composition-based stats. Identities = 38/235 (16%), Positives = 78/235 (33%), Gaps = 27/235 (11%) Query: 36 YRSDGALLLGASSLSGRCWAGS------LWLFKDPCAAPNEGFCSAGVQTEAGVADLTW- 88 ++ +G L ++ + GR +GS LW P + + + D W Sbjct: 159 HKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGS-GGDPTKPVRTWNDLHSDIINDNKWH 217 Query: 89 -VGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSV-LSSGTQAVSGSKD 146 + S+ +++ ++ N T I + C +T++ S + D Sbjct: 218 NFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQ----PFNTLAFSHHSSNLLAAAGMD 273 Query: 147 ICIKVWDLAQ-QVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDT-------- 197 + ++DL + L H V + S H D V +S DNR+++WD Sbjct: 274 SYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQT 333 Query: 198 ----RCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCV 248 P + + +PQ + +E + + + + Sbjct: 334 PDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCSHSLPI 388 >3ODT-A nrPDB Length = 313 Score = 105 bits (263), Expect = 2e-23, Method: Composition-based stats. Identities = 40/181 (22%), Positives = 70/181 (38%), Gaps = 16/181 (8%) Query: 119 FCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPH 178 + H V ++S G +SGS D KVW + ++ + +AH A V Sbjct: 98 YTLIGHQGNVCSLSF-QDGV-VISGSWDKTAKVW--KEGSLVYNLQAHNASVWDAKVVSF 153 Query: 179 KDSVFLSCSEDNRILLW-DTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTV 237 ++ FL+ S D I LW + + K S I +L F+ +G + Sbjct: 154 SENKFLTASADKTIKLWQNDKVIKTFSGIHNDVVRHLAVV------DDGHFISCSNDGLI 207 Query: 238 SLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVL---DSSLSELFRSQ 294 LVD + + + H V + P+ + S ED ++ + + SL ++ Sbjct: 208 KLVDMHTGDVLRTYEGHESFVYCIKLLPNGD--IVSCGEDRTVRIWSKENGSLKQVITLP 265 Query: 295 A 295 A Sbjct: 266 A 266 Score = 102 bits (255), Expect = 2e-22, Method: Composition-based stats. Identities = 47/206 (22%), Positives = 74/206 (35%), Gaps = 29/206 (14%) Query: 38 SDGALLLGASSLSGRCWAGSLWLFKDPCAAPNEGFCSAGVQT-EAGVADLTWVG--ERGI 94 DG ++ G+ + + W EG +Q A V D V E Sbjct: 113 QDGVVISGSWDKTAKVW--------------KEGSLVYNLQAHNASVWDAKVVSFSENKF 158 Query: 95 LVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDL 154 L AS ++LW + V K H+D+V ++V+ G S S D IK+ D+ Sbjct: 159 LTASADKTIKLW-----QNDKVIKTFSGIHNDVVRHLAVVDDGHFI-SCSNDGLIKLVDM 212 Query: 155 AQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYL 214 VL +Y H + V C+ P+ D +SC ED + +W I A Sbjct: 213 HTGDVLRTYEGHESFVYCIKLLPNGD--IVSCGEDRTVRIWSKENGSLKQVITLPAISIW 270 Query: 215 PTSLAWHPQQSEVFVFGDENGTVSLV 240 + + G + V + Sbjct: 271 SVDC----MSNGDIIVGSSDNLVRIF 292 Score = 92.1 bits (227), Expect = 3e-19, Method: Composition-based stats. Identities = 35/198 (17%), Positives = 65/198 (32%), Gaps = 18/198 (9%) Query: 94 ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSG-TQAVSGSKDICIKVW 152 ++ S ++W+ E +V H+ V V+S + ++ S D IK+W Sbjct: 117 VISGSWDKTAKVWK----EGSLVYNL--QAHNASVWDAKVVSFSENKFLTASADKTIKLW 170 Query: 153 DLAQQVVLSSYRA-HAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAP 211 V+ ++ H V +A D F+SCS D I L D Sbjct: 171 --QNDKVIKTFSGIHNDVVRHLAVV--DDGHFISCSNDGLIKLVDMHTGDVLRTYE--GH 224 Query: 212 GYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFL 271 + P V E+ TV + ++ S + + + + + + Sbjct: 225 ESFVYCIKLLPNGD--IVSCGEDRTVRIWSKENGSLKQVITLPAISIWSVDCMSNGD--I 280 Query: 272 ASLSEDCSLAVLDSSLSE 289 S D + + S Sbjct: 281 IVGSSDNLVRIFSQEKSR 298 Score = 74.0 bits (180), Expect = 9e-14, Method: Composition-based stats. Identities = 34/169 (20%), Positives = 59/169 (34%), Gaps = 12/169 (7%) Query: 158 VVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTS 217 + ++ + H DS S S D + LW + + + G+L S Sbjct: 9 QLSATLKGHDQD--VRDVVAVDDSKVASVSRDGTVRLWSKDD-QWLGTVVYTGQGFL-NS 64 Query: 218 LAWHPQQSEVFVFGDEN---GTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASL 274 + + + E+ +FG ++ V L T + + H V L F + S Sbjct: 65 VCYDS-EKELLLFGGKDTMINGVPLFATSGEDPLYTLIGHQGNVCSLSF---QDGVVISG 120 Query: 275 SEDCSLAVLDSSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQVV 323 S D + V S ++ QAH V DA + + T D + Sbjct: 121 SWDKTAKVW-KEGSLVYNLQAHNASVWDAKVVSFSENKFLTASADKTIK 168 Score = 66.3 bits (160), Expect = 2e-11, Method: Composition-based stats. Identities = 32/186 (17%), Positives = 60/186 (32%), Gaps = 13/186 (6%) Query: 138 TQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRIL---L 194 ++ S S+D +++W Q + + + V K + L +D I L Sbjct: 30 SKVASVSRDGTVRLWSKDDQWLGTVVYTGQGFLNSVCYDSEK-ELLLFGGKDTMINGVPL 88 Query: 195 WDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVH 254 + T P + SL++ V + G + T + K S V + H Sbjct: 89 FATSGEDPLYTLI--GHQGNVCSLSFQ---DGVVISGSWDKTAKVW--KEGSLVYNLQAH 141 Query: 255 SQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHRDFVRDATWSPLNHSLLT 314 + V S + S D ++ + + S H D VR ++ Sbjct: 142 NASVWDAKVVSFSENKFLTASADKTIKLWQNDKVIKTFSGIHNDVVRHLAV--VDDGHFI 199 Query: 315 TVGWDH 320 + D Sbjct: 200 SCSNDG 205 >5CXC-A nrPDB Length = 510 Score = 103 bits (257), Expect = 1e-22, Method: Composition-based stats. Identities = 45/250 (18%), Positives = 81/250 (32%), Gaps = 36/250 (14%) Query: 81 AGVADLTWVGERGILVASDSGAVELWELDENE---TLIVSKFCKYEHDDIVSTVSVLSSG 137 A + ++ + A V +W+ E++ + Y H V + V Sbjct: 193 ASIKAAKFLTSDRLASAGMDRTVRVWKYTESDHFTGELKPTLELYGHTGSVDWLDVDGHS 252 Query: 138 TQAVSGSKDICIKVWDL------------------------------AQQVVLSSYRAHA 167 ++ S D I W AQ+ L + H Sbjct: 253 KHILTASADGAIGFWSASKASAPEPDASLLPGAHVSKRRKATSSVSTAQRGPLGLWSIHT 312 Query: 168 AQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEV 227 A T P +V S S+D+ + D + S + + P ++L S + Sbjct: 313 APATAAIFDPRDRTVAYSASQDHTVRTLDLTTGQVVSTLTLTHPLLSLSALTRAGTTSPL 372 Query: 228 FVFGDENGTVSLVDTKSTS---CVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLD 284 G +++VD +++S V++ H+ V L SP + L S S D + V D Sbjct: 373 LAAGTSARHITMVDPRASSATTSVMTLRGHANKVVSLSPSPENEYSLVSGSHDGTCRVWD 432 Query: 285 SSLSELFRSQ 294 + Sbjct: 433 LRSVRPATKE 442 Score = 91.3 bits (225), Expect = 5e-19, Method: Composition-based stats. Identities = 44/274 (16%), Positives = 86/274 (31%), Gaps = 43/274 (15%) Query: 90 GERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICI 149 G+ +L AS G + +W + H + L + + S D + Sbjct: 157 GQERVLSASYDGLLRIWNASGSVIATSPSGSHGGHTASIKAAKFL-TSDRLASAGMDRTV 215 Query: 150 KVW-----DLAQQVVLSSYR--AHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRC--- 199 +VW D + + H V + H + + S D I W Sbjct: 216 RVWKYTESDHFTGELKPTLELYGHTGSVDWLDVDGHSKHIL-TASADGAIGFWSASKASA 274 Query: 200 PKPASQIGCSAPGY-------------------------LPTSLAWHPQQSEVFVFGDEN 234 P+P + + A T+ + P+ V ++ Sbjct: 275 PEPDASLLPGAHVSKRRKATSSVSTAQRGPLGLWSIHTAPATAAIFDPRDRTVAYSASQD 334 Query: 235 GTVSLVDTKSTSCV--LSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLD----SSLS 288 TV +D + V L+ ++ L + + P LA+ + + ++D S+ + Sbjct: 335 HTVRTLDLTTGQVVSTLTLTHPLLSLSALTRAGTTSPLLAAGTSARHITMVDPRASSATT 394 Query: 289 ELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQV 322 + + H + V + SP N L + D Sbjct: 395 SVMTLRGHANKVVSLSPSPENEYSLVSGSHDGTC 428 Score = 66.3 bits (160), Expect = 2e-11, Method: Composition-based stats. Identities = 36/234 (15%), Positives = 69/234 (29%), Gaps = 64/234 (27%) Query: 120 CKYEHDDIVSTVSV----LSSGTQ----------------AVSGSKDICIKVWDLAQQVV 159 +EHDD VS V V +G +S S D +++W+ A V Sbjct: 121 ASFEHDDWVSAVDVLSATSPAGRWSSAANSSAAVQPGQERVLSASYDGLLRIWN-ASGSV 179 Query: 160 LSS-----YRAHAAQVTCVAASPHKDSVFLSCSEDNRILLW-----DTRCPKPASQIGCS 209 +++ + H A + S D + +W D + + Sbjct: 180 IATSPSGSHGGHTASIKAAKFLTSDR--LASAGMDRTVRVWKYTESDHFTGELKPTLELY 237 Query: 210 APGYLPTSLAWHPQQSEVFVFGDENGTVSLVDT----------------------KSTSC 247 L + +G + K+TS Sbjct: 238 GHTGSVDWLDVDGHSKHIL-TASADGAIGFWSASKASAPEPDASLLPGAHVSKRRKATSS 296 Query: 248 VLSS--------AVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRS 293 V ++ ++H+ T +F P S S+D ++ LD + ++ + Sbjct: 297 VSTAQRGPLGLWSIHTAPATAAIFDPRDRTVAYSASQDHTVRTLDLTTGQVVST 350 Score = 58.2 bits (139), Expect = 5e-09, Method: Composition-based stats. Identities = 32/159 (20%), Positives = 57/159 (35%), Gaps = 17/159 (10%) Query: 96 VASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGT---QAVSGSKDICIKVW 152 AS V +L + V H ++S ++ +GT +G+ I + Sbjct: 330 SASQDHTVRTLDLTTGQ---VVSTLTLTHP-LLSLSALTRAGTTSPLLAAGTSARHITMV 385 Query: 153 DLAQQ---VVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTR-----CPKPAS 204 D + + R HA +V ++ SP + +S S D +WD R + S Sbjct: 386 DPRASSATTSVMTLRGHANKVVSLSPSPENEYSLVSGSHDGTCRVWDLRSVRPATKEEGS 445 Query: 205 QIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTV--SLVD 241 G S P Y+ +W + + + V + D Sbjct: 446 LGGVSEPVYVIERESWASKGKKKRPVAGDGCKVFSVVWD 484 >5A9Q-2 nrPDB Length = 326 Score = 102 bits (255), Expect = 2e-22, Method: Composition-based stats. Identities = 39/239 (16%), Positives = 85/239 (35%), Gaps = 24/239 (10%) Query: 112 ETLIVSKFCKYEHDDIVSTVSVLSSGTQ--------AVSGSKDICIKVW--DLAQQVVLS 161 E + + H V ++ + + D+ I+++ DL + Sbjct: 59 EGIQYKTLRTFHHGVRVDGIAWSPETRLDSLPPVIKFCTSAADMKIRLFTSDLQDKNEYK 118 Query: 162 SYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWH 221 H + + P + S S+D+ +W+ + +PG S+ WH Sbjct: 119 VLEGHTDFINGLVFDPKEGQEIASVSDDHTCRIWNLE-GVQTAHFVLHSPGM---SVCWH 174 Query: 222 PQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFS-PHSVPFLASLSEDCSL 280 P+++ + ++NGT+ D + +LS + + ++ A D Sbjct: 175 PEETFKLMVAEKNGTIRFYDLLAQQAILSLESEQVPLMSAHWCLKNTFKVGAVAGNDWL- 233 Query: 281 AVLD--SSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQV-----VHHVVPTEPL 332 + D S + H D WS ++ +L T G+ ++ +HH+ +P+ Sbjct: 234 -IWDITRSSYPQNKRPVHMDRACLFRWSTISENLFATTGYPGKMASQFQIHHLGHPQPI 291 Score = 77.5 bits (189), Expect = 8e-15, Method: Composition-based stats. Identities = 43/281 (15%), Positives = 88/281 (31%), Gaps = 40/281 (14%) Query: 70 EGFCSAGVQTE---AGVADLTWVGERGI---------LVASDSGAVELW--ELDENETLI 115 EG ++T V + W E + ++ + L+ +L + Sbjct: 59 EGIQYKTLRTFHHGVRVDGIAWSPETRLDSLPPVIKFCTSAADMKIRLFTSDLQDKNEYK 118 Query: 116 VSKFCKYEHDDIVSTVSVLS-SGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVA 174 V + H D ++ + G + S S D ++W+L V + + H+ V Sbjct: 119 VLE----GHTDFINGLVFDPKEGQEIASVSDDHTCRIWNLE-GVQTAHFVLHS-PGMSVC 172 Query: 175 ASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDEN 234 P + + ++ I +D + + S L ++ +V + Sbjct: 173 WHPEETFKLMVAEKNGTIRFYDLLAQQAILSL-ESEQVPLMSAHWCLKNTFKVGAVAGND 231 Query: 235 GTVSLVD-TKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRS 293 + D T+S+ VH +S S A+ +A S ++ Sbjct: 232 WL--IWDITRSSYPQNKRPVHMDRACLFRWSTISENLFATTGYPGKMA----SQFQIHHL 285 Query: 294 QAHRD--------FVRDATWSPLNHSLLTTVGWDHQVVHHV 326 H +W L +G DH+++ V Sbjct: 286 -GHPQPILMGSVAVGSGLSW--HRTLPLCVIGGDHKLLFWV 323 >2AQ5-A nrPDB Length = 402 Score = 102 bits (255), Expect = 2e-22, Method: Composition-based stats. Identities = 45/255 (17%), Positives = 83/255 (32%), Gaps = 20/255 (7%) Query: 93 GILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQ-AVSGSKDICIKV 151 I AS GA + L + + + H V ++ SGS+D + V Sbjct: 49 LICEASGGGAFLVLPLGKTGRVDKNVPLVCGHTAPVLDIAWCPHNDNVIASGSEDCTVMV 108 Query: 152 WDLAQQ-------VVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPAS 204 W++ + + H +V VA P +V LS DN IL+WD Sbjct: 109 WEIPDGGLVLPLREPVITLEGHTKRVGIVAWHPTAQNVLLSAGCDNVILVWDVGTGAAVL 168 Query: 205 QIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAV-HSQ--CVTGL 261 +G S+ W + + + V +++ + + V H V + Sbjct: 169 TLGPDVHPDTIYSVDW-SRDGALICTSCRDKRVRVIEPRKGTVVAEKDRPHEGTRPVHAV 227 Query: 262 VFSPHSVPFLASL---SEDCSLAVLDSSLSELFRSQAHRDFVRDAT---WSPLNHSLLTT 315 S L + + +A+ D+ E S D + P + + Sbjct: 228 FVS--EGKILTTGFSRMSERQVALWDTKHLEEPLSLQELDTSSGVLLPFFDPDTNIVYLC 285 Query: 316 VGWDHQVVHHVVPTE 330 D + + + +E Sbjct: 286 GKGDSSIRYFEITSE 300 Score = 36.3 bits (82), Expect = 0.018, Method: Composition-based stats. Identities = 11/41 (26%), Positives = 17/41 (41%) Query: 295 AHRDFVRDATWSPLNHSLLTTVGWDHQVVHHVVPTEPLPAP 335 H V D W P N +++ + D V+ +P L P Sbjct: 79 GHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLP 119 >5MWJ-A nrPDB Length = 337 Score = 100 bits (248), Expect = 1e-21, Method: Composition-based stats. Identities = 45/266 (16%), Positives = 86/266 (32%), Gaps = 10/266 (3%) Query: 66 AAPNEGFCSAGVQTEAGVADLTWVGERGILVASDSGAVELWEL-DENETLIVSKFCKYEH 124 P + V +T + G V++W++ VS+ Sbjct: 37 GIPRHARQINTLNHGEVVCAVTISNPTRHVYTGGKGCVKVWDISHPGNKSPVSQLDCLNR 96 Query: 125 DDIVSTVSVLSSGTQAVSGSKDICIKVWDLA--QQVVLSSYRAHAAQVTCVAASPHKDSV 182 D+ + + +L G + G + + +WDLA + + + A +A SP V Sbjct: 97 DNYIRSCKLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPD-SKV 155 Query: 183 FLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDT 242 SC D I +WD Q G ++ G + TV D Sbjct: 156 CFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDIS---NDGTKLWTGGLDNTVRSWDL 212 Query: 243 KSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHRDFVRD 302 + + + + L + P +LA E ++ VL + + ++ H V Sbjct: 213 REGRQLQQ-HDFTSQIFSLGYCPTGE-WLAVGMESSNVEVLHVNKPDKYQLHLHESCVLS 270 Query: 303 ATWSPLNHSLLTTVGWDHQVVHHVVP 328 ++ + G D+ + P Sbjct: 271 LKFA-YCGKWFVSTGKDNLLNAWRTP 295 Score = 96.0 bits (237), Expect = 2e-20, Method: Composition-based stats. Identities = 41/234 (17%), Positives = 83/234 (35%), Gaps = 10/234 (4%) Query: 94 ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWD 153 ++V ++ + +W+L I ++ +++ S D I VWD Sbjct: 112 LIVGGEASTLSIWDLAAPTPRIKAELTSSA--PACYALAISPDSKVCFSCCSDGNIAVWD 169 Query: 154 LAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGY 213 L Q ++ ++ H +C+ S + + + DN + WD R + Q ++ + Sbjct: 170 LHNQTLVRQFQGHTDGASCIDIS-NDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIF 228 Query: 214 LPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLAS 273 SL + P E G E+ V ++ + +H CV L F+ + + S Sbjct: 229 ---SLGYCP-TGEWLAVGMESSNVEVL-HVNKPDKYQLHLHESCVLSLKFA-YCGKWFVS 282 Query: 274 LSEDCSLAVLDSSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQVVHHVV 327 +D L + V S ++ + T D + + V Sbjct: 283 TGKDNLLNAWRTPYGASIFQSKESSSVLSCDIS-VDDKYIVTGSGDKKATVYEV 335 >5A9Q-7 nrPDB Length = 360 Score = 98.7 bits (244), Expect = 3e-21, Method: Composition-based stats. Identities = 43/248 (17%), Positives = 90/248 (36%), Gaps = 38/248 (15%) Query: 114 LIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQV---VLSSYRAHAAQV 170 + V++ +H D++ VS G + + S D +KVWD ++ +S++ H+ V Sbjct: 1 MFVARSIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSV 60 Query: 171 TCVAA-SPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAP----------GYLPTSLA 219 V P V SCS D +W+ + ++ + T + Sbjct: 61 WRVTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVK 120 Query: 220 WHPQQSEV-FVFGDENGTVSLVD-TKSTSCVLSSAVHSQ----CVTGLVFSPHS----VP 269 + P+ + +G V + + + S H + + ++P S P Sbjct: 121 FAPKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSP 180 Query: 270 FLASLSEDCS------LAVLDSSLSELFRSQAH-----RDFVRDATWSPLNH---SLLTT 315 +A S+D S + + + + + ++A D V D ++P +L Sbjct: 181 MIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAI 240 Query: 316 VGWDHQVV 323 D ++ Sbjct: 241 ATKDVRIF 248 Score = 54.0 bits (128), Expect = 1e-07, Method: Composition-based stats. Identities = 33/264 (12%), Positives = 75/264 (28%), Gaps = 60/264 (22%) Query: 73 CSAGVQTEAG-VADLTWVGERG---ILVASDSGAVELW--------ELDENETLIVSKFC 120 C+A +T +G V +TW + S +W + ++ V + Sbjct: 49 CTASWKTHSGSVWRVTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTT 108 Query: 121 KYEHDDIVSTVSVLSS--GTQAVSGSKDICIKV-----------WDLAQQVVLSSYRAHA 167 + V+ V G + S D +++ W L ++ Sbjct: 109 LVDSRTSVTDVKFAPKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISCKL----- 163 Query: 168 AQVTCVAASPHKDS----VFLSCSEDNR--------ILLWDTRCPKPASQIGCSAPGYLP 215 +C++ +P + S+D+ I ++ K A Sbjct: 164 -SCSCISWNPSSSRAHSPMIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTDPV 222 Query: 216 TSLAWHPQ---QSEVFVFGDENGTVSLVDTKST-------------SCVLSSAVHSQCVT 259 +A+ P + ++ + + V H+ V Sbjct: 223 HDIAFAPNLGRSFHILAIATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVW 282 Query: 260 GLVFSPHSVPFLASLSEDCSLAVL 283 + ++ + LAS +D + + Sbjct: 283 RVSWN-ITGTVLASSGDDGCVRLW 305 Score = 44.7 bits (104), Expect = 5e-05, Method: Composition-based stats. Identities = 22/165 (13%), Positives = 47/165 (28%), Gaps = 25/165 (15%) Query: 90 GERGILVASDS------GAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSS--GTQAV 141 I V SD V+++E +EN D V ++ + + + Sbjct: 178 HSPMIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHI 237 Query: 142 SGSKDICIKVWDLAQQV---------------VLSSYRAHAAQVTCVAASPHKDSVFLSC 186 ++++ L +++ + H +QV V+ + +V S Sbjct: 238 LAIATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWN-ITGTVLASS 296 Query: 187 SEDNRILLWDTRCPKPASQIG-CSAPGYLPTSLAWHPQQSEVFVF 230 +D + LW G G + + Sbjct: 297 GDDGCVRLWKANYMDNWKCTGILKGNGSPVNGSSQQGTSNPSLGS 341 >5OQL-L nrPDB Length = 557 Score = 98.7 bits (244), Expect = 3e-21, Method: Composition-based stats. Identities = 48/262 (18%), Positives = 94/262 (35%), Gaps = 21/262 (8%) Query: 86 LTWVGERGILVASDSGAVELWELDENETLIVS-KFCKYEHDDIVSTVSVLSSGTQAVSGS 144 + + + VE++ + + E L +F H + G V+G Sbjct: 64 VAAAKTNDLFAVTAGPRVEIFSIRKREPLKTIGRFDSEAHCGEIR-----PDGRVLVAGE 118 Query: 145 KDICIKVWDLAQQV---VLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPK 201 ++V+D+ Q +L ++ H V SP + + +SCS+D + LWD Sbjct: 119 DTGRMQVFDVGQGTRAVILKTWHIHKQPVWVTKWSPTELTTLMSCSDDKTVRLWDLPSND 178 Query: 202 PASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKS-TSCVLSSAVHSQCVTG 260 P + S + V G + TV + D ++ V++ H+ + Sbjct: 179 PTRLFTGHTDYVRCGAFMPGSANSNLLVSGSYDETVRVWDARAPGGAVMTFK-HADPIED 237 Query: 261 LVFSPHSVPFLASLSEDCSLAVLDS-SLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWD 319 ++ P LA+ +++VLD + L H+ V + + + + D Sbjct: 238 VLPLPSGTTLLAASG--NAISVLDLVAAKPLRLITNHQKTVTSLSLASQ-GRRVVSGSLD 294 Query: 320 HQVV------HHVVPTEPLPAP 335 V +VV P+P Sbjct: 295 GHVKVFETTSWNVVAGAKYPSP 316 >1NR0-A nrPDB Length = 611 Score = 98.3 bits (243), Expect = 4e-21, Method: Composition-based stats. Identities = 50/247 (20%), Positives = 78/247 (31%), Gaps = 23/247 (9%) Query: 93 GILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVW 152 I+ SD V ++E K EH V +V G+ S D I ++ Sbjct: 162 RIISGSDDNTVAIFE----GPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLY 217 Query: 153 DLAQQVVLSSYR-------AHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQ 205 + + AH+ V + SP + S S D I +W+ K Sbjct: 218 NGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKI-ASASADKTIKIWNVATLKVEKT 276 Query: 206 IGCSAPGYLPT-SLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFS 264 I + W + V NG ++ V+ + S H++ +T L S Sbjct: 277 IPVGTRIEDQQLGIIW---TKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALS-S 332 Query: 265 PHSVPFLASLSEDCSLAVLDSSLSELFRS--QAHRDFVRDATWSPLNHSLLTTVGWDHQV 322 L S + + D S R H + + L TV WD + Sbjct: 333 SADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGD--LFTVSWDDHL 390 Query: 323 VHHVVPT 329 VVP Sbjct: 391 K--VVPA 395 Score = 92.5 bits (228), Expect = 2e-19, Method: Composition-based stats. Identities = 37/222 (16%), Positives = 79/222 (35%), Gaps = 21/222 (9%) Query: 122 YEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLA--QQVVLSSYRAHAAQVTCVAASPHK 179 EH + SG SG +++WD ++ ++ + V ++ + Sbjct: 56 TEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDS-E 114 Query: 180 DSVFLSCSEDNR----ILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENG 235 + E + L+DT S + S+ + P + + G ++ Sbjct: 115 SKRIAAVGEGRERFGHVFLFDTGT----SNGNLTGQARAMNSVDFKPSRPFRIISGSDDN 170 Query: 236 TVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVL---DSSLSELFR 292 TV++ + + H++ V + ++P AS D ++ + D + + +F Sbjct: 171 TVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDG-SLFASTGGDGTIVLYNGVDGTKTGVFE 229 Query: 293 SQ-----AHRDFVRDATWSPLNHSLLTTVGWDHQVVHHVVPT 329 AH V TWSP + + + + D + V T Sbjct: 230 DDSLKNVAHSGSVFGLTWSP-DGTKIASASADKTIKIWNVAT 270 Score = 72.5 bits (176), Expect = 3e-13, Method: Composition-based stats. Identities = 29/162 (17%), Positives = 62/162 (38%), Gaps = 11/162 (6%) Query: 86 LTWVGERGIL-VASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGS 144 + ++ + V V +++L VS+ H +++V+ ++G V+ Sbjct: 454 VALSNDKQFVAVGGQDSKVHVYKLSG---ASVSEVKTIVHPAEITSVAFSNNGAFLVATD 510 Query: 145 KDICIKVWDLAQQVVLS---SYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPK 201 + + + +A L+ S+ H A+V CV+ SP + S DN +++W+ P Sbjct: 511 QSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVR-LATGSLDNSVIVWNMNKPS 569 Query: 202 PASQIGCSAPG-YLPTSLAWHPQQSEVFVFGDENGTVSLVDT 242 I A S+ W V ++ + + Sbjct: 570 DHPIIIKGAHAMSSVNSVIW--LNETTIVSAGQDSNIKFWNV 609 Score = 63.6 bits (153), Expect = 1e-10, Method: Composition-based stats. Identities = 24/127 (18%), Positives = 45/127 (35%), Gaps = 5/127 (3%) Query: 74 SAGVQTEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSV 133 + A + + + LVA+D + N + H V+ VS Sbjct: 485 VKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSW 544 Query: 134 LSSGTQAVSGSKDICIKVWDLA--QQVVLSSYRAHA-AQVTCVAASPHKDSVFLSCSEDN 190 + +GS D + VW++ + AHA + V V ++ +S +D+ Sbjct: 545 SPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIW--LNETTIVSAGQDS 602 Query: 191 RILLWDT 197 I W+ Sbjct: 603 NIKFWNV 609 Score = 62.4 bits (150), Expect = 2e-10, Method: Composition-based stats. Identities = 33/198 (16%), Positives = 61/198 (30%), Gaps = 15/198 (7%) Query: 92 RGILVASDSGAVELWELDENETLIVSK---FCKYEHDDIVSTVSVLSSGTQAVSGSKDIC 148 G + L+ + V + H V ++ GT+ S S D Sbjct: 203 SLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKT 262 Query: 149 IKVWDLAQQVVLSSYRAHA---AQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQ 205 IK+W++A V + Q + + +S S + I + P+ S Sbjct: 263 IKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQA---LVSISANGFI---NFVNPELGSI 316 Query: 206 IGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSS-AVHSQCVTGLVFS 264 + + D G ++ D + VH+ +TG+ + Sbjct: 317 DQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTT 376 Query: 265 PHSVPFLASLSEDCSLAV 282 L ++S D L V Sbjct: 377 SKGD--LFTVSWDDHLKV 392 Score = 59.8 bits (143), Expect = 2e-09, Method: Composition-based stats. Identities = 34/164 (20%), Positives = 64/164 (39%), Gaps = 13/164 (7%) Query: 172 CVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFG 231 CVA S K V + +D+++ ++ S++ TS+A+ + + Sbjct: 453 CVALSNDKQFVAV-GGQDSKVHVYKL-SGASVSEVKTIVHPAEITSVAFSNNGAFLVAT- 509 Query: 232 DENGTVSLVDTKSTSCVLS---SAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSL- 287 D++ V + + H+ V + +SP +V LA+ S D S+ V + + Sbjct: 510 DQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVR-LATGSLDNSVIVWNMNKP 568 Query: 288 --SELFRSQAHR-DFVRDATWSPLNHSLLTTVGWDHQVVHHVVP 328 + AH V W LN + + + G D + VP Sbjct: 569 SDHPIIIKGAHAMSSVNSVIW--LNETTIVSAGQDSNIKFWNVP 610 Score = 34.7 bits (78), Expect = 0.052, Method: Composition-based stats. Identities = 15/79 (18%), Positives = 27/79 (34%), Gaps = 10/79 (12%) Query: 36 YRSDGALLLGASSLSGRCWAGSL------WLFKDPCAAPNEGFCSAGVQTEAGVADLTWV 89 + + A + + + R GSL W P P G + V + W+ Sbjct: 535 HTAKVACVSWSPD-NVRLATGSLDNSVIVWNMNKPSDHP---IIIKGAHAMSSVNSVIWL 590 Query: 90 GERGILVASDSGAVELWEL 108 E I+ A ++ W + Sbjct: 591 NETTIVSAGQDSNIKFWNV 609 >4XFV-A nrPDB Length = 792 Score = 98.3 bits (243), Expect = 4e-21, Method: Composition-based stats. Identities = 55/306 (17%), Positives = 95/306 (31%), Gaps = 61/306 (19%) Query: 65 CAAPNEGFCSAGVQTEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEH 124 C P F A QT V+D+ V + I+ + LW+ E V K H Sbjct: 8 CITPEAIFIGANKQT--QVSDIHKV--KKIVAFGAGKTIALWDPIEPNNKGVYATLK-GH 62 Query: 125 DDIVSTVSVLSSGTQAVSGSKDICIKVW---DLAQQVVLSSYRAHAAQVTCVAASPHKDS 181 + V+ V + VS S+D +K+W D + + + + ++ + ++A P S Sbjct: 63 EAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALP---S 119 Query: 182 VFLSCSEDNRILLWDTRCPKPASQIGCSAPGY------LPTSLAWHPQQSEVFVFGDENG 235 + D I +W + L SL+ ++ + G N Sbjct: 120 LISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNV 179 Query: 236 TVSLV-----DTKSTSC--VLSSAVHSQCVTGLVFSPHSVP---FLASLSEDCSLAVLDS 285 V + D+ C V H V L F P L S S+D + + Sbjct: 180 NVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRI 239 Query: 286 SL------------------SELFRSQ----------------AHRDFVRDATWSPLNHS 311 + ++ ++ Q H D++ W Sbjct: 240 RINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQ 299 Query: 312 LLTTVG 317 LL Sbjct: 300 LLAATA 305 Score = 69.4 bits (168), Expect = 2e-12, Method: Composition-based stats. Identities = 27/188 (14%), Positives = 62/188 (32%), Gaps = 18/188 (9%) Query: 120 CKYEHDDIVSTVSVLSSGTQAVSGSK-----DICIKVWDLAQQVVLS-SYRAHAAQVTCV 173 Y H ++ + + S + + I+++ + + + H+ +T + Sbjct: 557 KLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRL 616 Query: 174 AASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSA---PGYLPTSLAWHPQQ-SEVFV 229 S LS D + LW+ ++ + W P + VFV Sbjct: 617 KFSKD-GKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFV 675 Query: 230 FGDENGTVSLV----DTKSTSCVLSSAVHSQCVTGLVFSPH--SVPFLASLS-EDCSLAV 282 + TV + + + +S H++ VT + L S+ E+ + + Sbjct: 676 TASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIYL 735 Query: 283 LDSSLSEL 290 +L + Sbjct: 736 YSYTLGKF 743 Score = 65.1 bits (157), Expect = 4e-11, Method: Composition-based stats. Identities = 35/223 (15%), Positives = 76/223 (34%), Gaps = 22/223 (9%) Query: 83 VADLTWVGERGIL-VASDSGAVE--LWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQ 139 + L ++ ++ A S V+ + + E + K H ++ + G Sbjct: 565 ITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGKF 624 Query: 140 AVSGSKDICIKVW-----DLAQQVVLSSYRAHAAQVTCVAASP-HKDSVFLSCSEDNRIL 193 +S +D +W D ++ + + H + +P +VF++ S D + Sbjct: 625 LLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVK 684 Query: 194 LWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSE-----VFVFGDENGTVSLVDTKSTSCV 248 +W + + ++ + A S + G ENG + L Sbjct: 685 VWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIYLYSYTLGKFE 744 Query: 249 LSSAVH-----SQCVTGLVFSP---HSVPFLASLSEDCSLAVL 283 L + ++ + +T L +S + FL S D S + Sbjct: 745 LITQLNEDITPADKITRLRWSHLKRNGKLFLGVGSSDLSTRIY 787 Score = 62.4 bits (150), Expect = 2e-10, Method: Composition-based stats. Identities = 32/216 (14%), Positives = 71/216 (32%), Gaps = 54/216 (25%) Query: 121 KYEHDDIVSTVSVLSS---GTQAV-SGSKDICIKVWDLAQQVVLSSYR------------ 164 H+D V +++ G + SGS+D I++W + ++ Sbjct: 202 LEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNK 261 Query: 165 ---------------------AHAAQVTCVAASPHKDSVFLSCSE--------DNRILLW 195 H ++ + + + + ++ D +W Sbjct: 262 QYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIW 321 Query: 196 --DTRCPKPASQIGCSAPGYLPT--SLAWHPQQS-EVFVFGDENGTVSLVDTK-STSCVL 249 R + +S+ +A G S W + + F+ + G+ + TK + C Sbjct: 322 VCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQ 381 Query: 250 SS--AVHSQCVTGLVFSPHSVPFLASLSEDCSLAVL 283 + ++ VT + +SP LA+ S D + + Sbjct: 382 RLGISGATKDVTDIAWSPSGEYLLAT-SLDQTTRLF 416 Score = 62.1 bits (149), Expect = 4e-10, Method: Composition-based stats. Identities = 29/197 (14%), Positives = 56/197 (28%), Gaps = 47/197 (23%) Query: 90 GERGILVASDSGAVELWELDENE-----------------------------TLIVSKFC 120 G+ + S + LW + N+ I + Sbjct: 221 GDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEAL 280 Query: 121 KYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLA---------------QQVVLSSYRA 165 HDD +S++ S Q ++ + D + VW+ S+ Sbjct: 281 IMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATG 340 Query: 166 HAAQVT-CVAASPHKDSVFLSCSEDNRILLWDT-RCPKPASQIGCSAPGYLPTSLAWHPQ 223 + C+ + + FL+ + +W T ++G S T +AW P Sbjct: 341 SSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPS 400 Query: 224 QSEVFVFGDENGTVSLV 240 + + T L Sbjct: 401 GEYLLAT-SLDQTTRLF 416 Score = 55.1 bits (131), Expect = 4e-08, Method: Composition-based stats. Identities = 24/183 (13%), Positives = 57/183 (31%), Gaps = 21/183 (11%) Query: 160 LSSYRAHAAQVTCVAASPHKDSVFLSCSEDNR-----ILLWDTRCPKPASQIGCSAPGYL 214 + H ++TC+ SP + + S N I ++ T Sbjct: 555 VEKLYGHGFEITCLDISPDQ-KLIASACRSNNVQNAVIRIFSTENWLEIKP-ALPFHSLT 612 Query: 215 PTSLAWHPQQSEVFVFGDENGTVSLV-----DTKSTSCVLSSAVHSQCVTGLVFSPHS-V 268 T L + + + + + +L D + H++ + ++P Sbjct: 613 ITRLKF-SKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFG 671 Query: 269 PFLASLSEDCSLAVLDSSLSEL--FRSQA---HRDFVRDATWSP--LNHSLLTTVGWDHQ 321 + S D ++ V + +A H V + + +L +VG ++ Sbjct: 672 NVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENG 731 Query: 322 VVH 324 ++ Sbjct: 732 EIY 734 Score = 51.3 bits (121), Expect = 6e-07, Method: Composition-based stats. Identities = 60/408 (14%), Positives = 111/408 (27%), Gaps = 114/408 (27%) Query: 28 ERQLEAARYRSDGALLLGASSLSGRCWAGSLWLFKDPCAAPNEGFCSAGVQTEAGVADLT 87 E +L+ +D +L++ + W SL L + ++G +A + + L Sbjct: 295 ESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGE----MSSKGASTATGSSGGFWSCLW 350 Query: 88 WVGERG--ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSK 145 + ER L +G+ +W ++ + + V+ ++ SG ++ S Sbjct: 351 FTHERMDFFLTNGKTGSWRMW-ATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSL 409 Query: 146 DICIKV---W---------DLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRIL 193 D ++ W ++A S + H + CV F+S ++ + Sbjct: 410 DQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVETVTDTR--FVSGGDEKILR 467 Query: 194 LWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENG------------------ 235 +D + S P + V V G N Sbjct: 468 SFDLPKGVAGMLQKFVGIQFEEKSEM--PDSATVPVLGLSNKAGEDDANEDDEEEEGGNK 525 Query: 236 -TVSLVDTKS----------------TSCVLSSAVHSQCVTGLVFSPHSVPFLASL---- 274 T + D S V H +T L SP +AS Sbjct: 526 ETPDITDPLSLLECPPMEDQLQRHLLWPEVEKLYGHGFEITCLDISPDQ-KLIASACRSN 584 Query: 275 --------------------------------------------SEDCSLAVLDSSLS-- 288 D A+ + ++ Sbjct: 585 NVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDN 644 Query: 289 ----ELFRSQAHRDFVRDATWSPLN-HSLLTTVGWDHQVVHHVVPTEP 331 + H + DA W+PL ++ T D V EP Sbjct: 645 TFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQKEP 692 Score = 36.3 bits (82), Expect = 0.021, Method: Composition-based stats. Identities = 18/130 (13%), Positives = 40/130 (30%), Gaps = 15/130 (11%) Query: 83 VADLTWVGERG---ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVL----S 135 + D W + AS V++W + +H V+ +S+ Sbjct: 660 IWDADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIR 719 Query: 136 SGTQAVSGSKDICIKVWD--LAQQVVLSSYRAHAAQ---VTCVAAS--PHKDSVFLS-CS 187 G ++ I ++ L + +++ +T + S +FL S Sbjct: 720 EKILISVGLENGEIYLYSYTLGKFELITQLNEDITPADKITRLRWSHLKRNGKLFLGVGS 779 Query: 188 EDNRILLWDT 197 D ++ Sbjct: 780 SDLSTRIYSL 789 >5N4A-A nrPDB Length = 771 Score = 97.9 bits (242), Expect = 6e-21, Method: Composition-based stats. Identities = 47/237 (19%), Positives = 80/237 (33%), Gaps = 15/237 (6%) Query: 86 LTWVGERGILVASDSGAVELWELDENETLIVSKFCKY---EHDDIVSTVSVLSSGT--QA 140 + W + SD + W + VS Y H VS+ + GT A Sbjct: 20 VGWNVWNELFTCSDDQTIHKWNMLGEPEQKVSTLDAYFTDMHWYPVSSKKTQAGGTDVFA 79 Query: 141 VSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCP 200 V+ + D +K+ V S H + S + + + ED + +W +R Sbjct: 80 VACT-DGSVKILS-RTGRVEKSIEGHKGACISLRWS-YDGTALATAGEDGSVKIW-SRNG 135 Query: 201 KPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTG 260 S + + S+ W ++ N + S + + H V Sbjct: 136 MLRSTLAQA--DSPVYSIVWAYDCDQLCYCTGSNVVIK--SLSSNAKQNAWKAHDGVVLK 191 Query: 261 LVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHRDFVRDATWSPLNHSLLTTVG 317 + +SP + + + EDC V DS LF+S V W+P + L G Sbjct: 192 VDWSPINH-LIITGGEDCKYKVWDSFGRLLFQSGLFDYPVTSVAWAP-SGELFAVGG 246 Score = 83.3 bits (204), Expect = 1e-16, Method: Composition-based stats. Identities = 33/212 (15%), Positives = 71/212 (33%), Gaps = 21/212 (9%) Query: 74 SAGVQTEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSV 133 + +T+AG D+ VA G+V++ + H ++ Sbjct: 65 VSSKKTQAGGTDV-------FAVACTDGSVKILSRTGR-----VEKSIEGHKGACISLRW 112 Query: 134 LSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRIL 193 GT + +D +K+W ++ S+ + V + + D + + I Sbjct: 113 SYDGTALATAGEDGSVKIWS-RNGMLRSTLAQADSPVYSIVWAYDCDQLCYCTGSNVVIK 171 Query: 194 LWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAV 253 A Q A + + W P + + + G E+ + D + S + Sbjct: 172 ----SLSSNAKQNAWKAHDGVVLKVDWSPI-NHLIITGGEDCKYKVWD-SFGRLLFQSGL 225 Query: 254 HSQCVTGLVFSPHSVPFLASLSEDCSLAVLDS 285 VT + ++P L ++ +L + D Sbjct: 226 FDYPVTSVAWAPSGE--LFAVGGFNTLQLCDR 255 Score = 31.6 bits (70), Expect = 0.47, Method: Composition-based stats. Identities = 10/66 (15%), Positives = 24/66 (36%), Gaps = 2/66 (3%) Query: 254 HSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHRDFVRDATWSPLNHSLL 313 HS+ + ++ + L + S+D ++ + + + D W P++ Sbjct: 13 HSELTAAVGWNVWNE--LFTCSDDQTIHKWNMLGEPEQKVSTLDAYFTDMHWYPVSSKKT 70 Query: 314 TTVGWD 319 G D Sbjct: 71 QAGGTD 76 >4U1E-I nrPDB Length = 347 Score = 96.0 bits (237), Expect = 2e-20, Method: Composition-based stats. Identities = 43/244 (17%), Positives = 88/244 (36%), Gaps = 23/244 (9%) Query: 92 RGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKV 151 + S + +W E L H + ++ V V+GS D IK+ Sbjct: 23 DLLFSCSKDSSASVWYSLNGERLGT----LDGHTGTIWSIDVDCFTKYCVTGSADYSIKL 78 Query: 152 WDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFL----SCSEDNRILLWDTR--------- 198 WD++ ++++++ V V SP + I +++ Sbjct: 79 WDVSNGQCVATWKS-PVPVKRVEFSPCGNYFLAILDNVMKNPGSINIYEIERDSATHELT 137 Query: 199 --CPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKST-SCVLSSAVHS 255 +P +I T W + + G ++G +S D + V S +H Sbjct: 138 KVSEEPIHKIITHEGLDAATVAGWSTKGKYIIA-GHKDGKISKYDVSNNYEYVDSIDLHE 196 Query: 256 QCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHRDFVRDATWSPLNHSLLTT 315 + ++ + FSP F+ S S D + ++D S ++ + + A +PL ++ Sbjct: 197 KSISDMQFSPDLTYFITS-SRDTNSFLVDVSTLQVLKKYETDCPLNTAVITPLKEFIILG 255 Query: 316 VGWD 319 G + Sbjct: 256 GGQE 259 Score = 95.6 bits (236), Expect = 2e-20, Method: Composition-based stats. Identities = 34/220 (15%), Positives = 66/220 (30%), Gaps = 25/220 (11%) Query: 119 FCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPH 178 H+ ++ V G S SKD VW L + H + + Sbjct: 4 IKLTGHERPLTQVKYNKEGDLLFSCSKDSSASVWYSLNGERLGTLDGHTGTIWSIDVD-C 62 Query: 179 KDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGD----EN 234 ++ S D I LWD + + P + + P + D Sbjct: 63 FTKYCVTGSADYSIKLWDVSNGQCVATWKSPVP---VKRVEFSPCGNYFLAILDNVMKNP 119 Query: 235 GTVSLVDT-----------KSTSCVLSSAVHSQ--CVTGLVFSPHSVPFLASLSEDCSLA 281 G++++ + S + H T +S ++ + +D ++ Sbjct: 120 GSINIYEIERDSATHELTKVSEEPIHKIITHEGLDAATVAGWS-TKGKYIIAGHKDGKIS 178 Query: 282 VLDSSLSELF--RSQAHRDFVRDATWSPLNHSLLTTVGWD 319 D S + + H + D +SP + + T D Sbjct: 179 KYDVSNNYEYVDSIDLHEKSISDMQFSP-DLTYFITSSRD 217 Score = 69.8 bits (169), Expect = 1e-12, Method: Composition-based stats. Identities = 47/338 (13%), Positives = 96/338 (28%), Gaps = 65/338 (19%) Query: 28 ERQLEAARYRSDGALLLGASSLSGRCWAGSLWLFKDPCAAPNEGFCSAGVQTEAGVADLT 87 ER L +Y +G LL S S + S+W + G + G Sbjct: 10 ERPLTQVKYNKEGDLLFSCSKDS----SASVWYSLN-------GERLGTLDGHTGTI--- 55 Query: 88 WVGE-----RGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVS 142 W + + + S +++LW++ + + K V V G ++ Sbjct: 56 WSIDVDCFTKYCVTGSADYSIKLWDVSNGQCVATWKSPV-----PVKRVEFSPCGNYFLA 110 Query: 143 GSKD-----ICIKVWDLA-----------QQVVLSSYRAHAA-QVTCVAASPHKDSVFLS 185 + I ++++ + + H VA K ++ Sbjct: 111 ILDNVMKNPGSINIYEIERDSATHELTKVSEEPIHKIITHEGLDAATVAGWSTKGKYIIA 170 Query: 186 CSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKST 245 +D +I +D + + + P + F+ + LVD + Sbjct: 171 GHKDGKISKYDVSNNYEYVD-SIDLHEKSISDMQFSPDLTY-FITSSRDTNSFLVDVSTL 228 Query: 246 SCVLSSAVHSQCVTGLVFSPHSVPFLASLS---EDCSL--------------AVLDSSLS 288 + + V +P + +D + + + Sbjct: 229 QVLKKYET-DCPLNTAVITPLKEFIILGGGQEAKDVTTTSANEGKFEARFYHKIFE---E 284 Query: 289 ELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQVVHHV 326 E+ R Q H + SP S + G D + H Sbjct: 285 EIGRVQGHFGPLNTVAISPQGTSY-ASGGEDGFIRLHH 321 >5K0Y-T nrPDB Length = 329 Score = 91.7 bits (226), Expect = 4e-19, Method: Composition-based stats. Identities = 39/220 (17%), Positives = 70/220 (31%), Gaps = 19/220 (8%) Query: 116 VSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAA 175 + H+ ++ + G + +KD + VW L +Y H V CV A Sbjct: 1 MRPILLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDA 60 Query: 176 SPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENG 235 V + S DN LWD K + + ++ + + +F + Sbjct: 61 DWDTKHVL-TGSADNSCRLWDCETGKQLALLKTNSAV-RTCGFDF---GGNIIMFSTDKQ 115 Query: 236 -----TVSLVDTKSTSCV------LSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLD 284 VS D + S + + + +T V+ P +A E L Sbjct: 116 MGYQCFVSFFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIA-GHESGELNQYS 174 Query: 285 SSLSE-LFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQVV 323 + E L + H + D S ++ T D+ Sbjct: 175 AKSGEVLVNVKEHSRQINDIQLS-REMTMFVTASKDNTAK 213 Score = 89.8 bits (221), Expect = 1e-18, Method: Composition-based stats. Identities = 42/249 (16%), Positives = 81/249 (32%), Gaps = 16/249 (6%) Query: 80 EAGVADLTWVGE-RGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGT 138 E + + + E + + V +W E L H V V Sbjct: 10 ERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYM----GHTGAVWCVDADWDTK 65 Query: 139 QAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSC----SEDNRILL 194 ++GS D ++WD L+ + + V + + S + Sbjct: 66 HVLTGSADNSCRLWDCETGKQLALLKT-NSAVRTCGFDFGGNIIMFSTDKQMGYQCFVSF 124 Query: 195 WDTRCPKPAS----QIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLS 250 +D R P + TS W P E + G E+G ++ KS +++ Sbjct: 125 FDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPL-GECIIAGHESGELNQYSAKSGEVLVN 183 Query: 251 SAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHRDFVRDATWSPLNH 310 HS+ + + S + + S+D + + DS+ E ++ A SP Sbjct: 184 VKEHSRQINDIQLS-REMTMFVTASKDNTAKLFDSTTLEHQKTFRTEPPRELAALSPNYE 242 Query: 311 SLLTTVGWD 319 ++ G + Sbjct: 243 HVVVGGGQE 251 Score = 71.7 bits (174), Expect = 5e-13, Method: Composition-based stats. Identities = 25/170 (14%), Positives = 60/170 (35%), Gaps = 12/170 (7%) Query: 124 HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVF 183 +D +++ G ++G + + + VL + + H+ Q+ + S + ++F Sbjct: 145 NDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEVLVNVKEHSRQINDIQLS-REMTMF 203 Query: 184 LSCSEDNRILLWDTRCPK--------PASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENG 235 ++ S+DN L+D+ + P ++ +P Y + + +V G Sbjct: 204 VTASKDNTAKLFDSTTLEHQKTFRTEPPRELAALSPNYEHVVVGGGQEAMDVTTTSTRIG 263 Query: 236 TV--SLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVL 283 H + + F P + +S ED + + Sbjct: 264 KFEARFFHLAFEEEFGRVKGHFGPINSVAFHPDGKSY-SSGGEDGYVRIH 312 Score = 58.2 bits (139), Expect = 4e-09, Method: Composition-based stats. Identities = 36/196 (18%), Positives = 70/196 (35%), Gaps = 20/196 (10%) Query: 57 SLWLFKDPCAAPNEGFCSAGVQTEAGVADLTWVG-ERGILVASDSGAVELWELDENETLI 115 S + +DP N ++ + W I+ +SG + + E L+ Sbjct: 123 SFFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEVLV 182 Query: 116 VSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCV-A 174 K EH ++ + + T V+ SKD K++D ++R + A Sbjct: 183 NVK----EHSRQINDIQLSREMTMFVTASKDNTAKLFDSTTLEHQKTFR--TEPPRELAA 236 Query: 175 ASPHKDSVFLSCSEDNR-ILLWDTRCPKPASQIGC----------SAPGYLPTSLAWHPQ 223 SP+ + V + ++ + TR K ++ S+A+HP Sbjct: 237 LSPNYEHVVVGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHP- 295 Query: 224 QSEVFVFGDENGTVSL 239 + + G E+G V + Sbjct: 296 DGKSYSSGGEDGYVRI 311 >2PM9-A nrPDB Length = 416 Score = 91.3 bits (225), Expect = 5e-19, Method: Composition-based stats. Identities = 62/336 (18%), Positives = 95/336 (28%), Gaps = 83/336 (24%) Query: 74 SAGVQTEAGVADLTWVGERGILVAS-DSGAVELWELDENETLIVSKFCKYEHDDIVSTVS 132 A +Q ++ DL W I+ + D+G++EL+ +E I S H V TV Sbjct: 61 IASLQVDSKFNDLDWSHNNKIIAGALDNGSLELYSTNEANNAINSMARFSNHSSSVKTVK 120 Query: 133 VLSSGTQ-AVSGSKDICIKVWDL----AQQVVLSSYRAHA-----AQVTCVAASPHKDSV 182 + SG + I +WD+ + +V +A + V Sbjct: 121 FNAKQDNVLASGGNNGEIFIWDMNKCTESPSNYTPLTPGQSMSSVDEVISLAWNQSLAHV 180 Query: 183 FLSCS----------------------------------------------------EDN 190 F S D Sbjct: 181 FASAGSSNFASIWDLKAKKEVIHLSYTSPNSGIKQQLSVVEWHPKNSTRVATATGSDNDP 240 Query: 191 RILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLS 250 IL+WD R Q SL W Q + + + TV L + +S + Sbjct: 241 SILIWDLRNANTPLQTLNQGHQKGILSLDWCHQDEHLLLSSGRDNTVLLWNPESAEQLSQ 300 Query: 251 SAVHSQCVTGLVFSPHSVPFLASLSEDCSLAV---------LDSSLSELFRSQAHRDFVR 301 F+P + A S D + V LD +E + ++ DF Sbjct: 301 FPARGNWCFKTKFAPEAPDLFACASFDNKIEVQTLQNLTNTLDEQETETKQQESETDFWN 360 Query: 302 DATWSPLNHSLLTTVGWDHQVVHHVVPT---EPLPA 334 + S V H PT EP PA Sbjct: 361 NV---SREESK-----EKPSVFHLQAPTWYGEPSPA 388 Score = 57.4 bits (137), Expect = 9e-09, Method: Composition-based stats. Identities = 30/168 (17%), Positives = 54/168 (32%), Gaps = 25/168 (14%) Query: 174 AASPHKDSVFLSC----------SEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQ 223 A S K + +S S D+ + LW I L W Sbjct: 19 AWSHDKIPLLVSGTVSGTVDANFSTDSSLELWSLLAADSEKPIASLQVDSKFNDLDW-SH 77 Query: 224 QSEVFVFGDENGTVSLVDTKST----SCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCS 279 +++ +NG++ L T + + + HS V + F+ LAS + Sbjct: 78 NNKIIAGALDNGSLELYSTNEANNAINSMARFSNHSSSVKTVKFNAKQDNVLASGGNNGE 137 Query: 280 LAVLD--------SSLSELFRSQAHR--DFVRDATWSPLNHSLLTTVG 317 + + D S+ + L Q+ D V W+ + + G Sbjct: 138 IFIWDMNKCTESPSNYTPLTPGQSMSSVDEVISLAWNQSLAHVFASAG 185 >5WLC-LJ nrPDB Length = 513 Score = 91.0 bits (224), Expect = 7e-19, Method: Composition-based stats. Identities = 29/209 (13%), Positives = 73/209 (34%), Gaps = 12/209 (5%) Query: 114 LIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCV 173 S EH + V+ +S + + ++++ + V+ ++ V Sbjct: 29 QYTSAQLVKEH-NSVTHISFNPQHPHDFAVTSSTRVQIFSSRTRQVIKTFSRFKDVVYSA 87 Query: 174 AASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDE 233 + + + + ++D+ P+ + +A + +H Q +++ + Sbjct: 88 SFRSD-GKLLCAGDATGLVSVYDSYNPRTI-LLSINASTHPTHVTKFHTQDNKILATASD 145 Query: 234 NGTVSLVDTKST-SCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLS---E 289 + L D + L + V L F P + +A+ S D + + D+ S Sbjct: 146 DRVTRLWDISNAYEPQLELTGATDYVRTLSFIPAAPHLVATGSYDGLIRLYDTRSSGSTP 205 Query: 290 LFRSQAHRDFVRDA-TWSPLNHSLLTTVG 317 ++ H V + SP + + + G Sbjct: 206 IYSLN-HDQPVENVIAVSP---TQIVSCG 230 Score = 85.2 bits (209), Expect = 4e-17, Method: Composition-based stats. Identities = 38/220 (17%), Positives = 74/220 (33%), Gaps = 20/220 (9%) Query: 77 VQTEAGVADLTWVGE-----RGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTV 131 ++T + D+ + + + +G V +++ N I+ H V+ Sbjct: 74 IKTFSRFKDVVYSASFRSDGKLLCAGDATGLVSVYD-SYNPRTILLSINASTHPTHVT-- 130 Query: 132 SVL-SSGTQAVSGSKDICIKVWDLAQQVVLS-SYRAHAAQVTCVAASPHKDSVFLSCSED 189 + S D ++WD++ V ++ P + + S D Sbjct: 131 KFHTQDNKILATASDDRVTRLWDISNAYEPQLELTGATDYVRTLSFIPAAPHLVATGSYD 190 Query: 190 NRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVL 249 I L+DTR + + +A P +++ G N + D S + Sbjct: 191 GLIRLYDTRSSGSTPIYSLNHDQPVENVIAVSP--TQIVSCGGNN--FKVWDLTSNKKLY 246 Query: 250 SSAVHSQCVTGLVF-----SPHSVPFLASLSEDCSLAVLD 284 ++ VT L + SP +AS S D + V D Sbjct: 247 ERGNFNKAVTCLDYVENFDSPMQSALIAS-SLDGHVKVFD 285 Score = 71.3 bits (173), Expect = 6e-13, Method: Composition-based stats. Identities = 31/175 (17%), Positives = 57/175 (32%), Gaps = 8/175 (4%) Query: 154 LAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGY 213 Q + H VT ++ +P F S + ++ +R + Sbjct: 27 WRQYTSAQLVKEHN-SVTHISFNPQHPHDFAVTSSTR-VQIFSSRTRQVIKTFSRFKDVV 84 Query: 214 LPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVL-SSAVHSQCVTGLVFSPHSVPFLA 272 S ++ GD G VS+ D+ + +L S + F LA Sbjct: 85 YSASFR---SDGKLLCAGDATGLVSVYDSYNPRTILLSINASTHPTHVTKFHTQDNKILA 141 Query: 273 SLSEDCSLAVLDSSL--SELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQVVHH 325 + S+D + D S D+VR ++ P L+ T +D + + Sbjct: 142 TASDDRVTRLWDISNAYEPQLELTGATDYVRTLSFIPAAPHLVATGSYDGLIRLY 196 >3F3P-A nrPDB Length = 351 Score = 91.0 bits (224), Expect = 7e-19, Method: Composition-based stats. Identities = 48/255 (18%), Positives = 81/255 (31%), Gaps = 34/255 (13%) Query: 121 KYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQV----VLSSYRAHAAQVTCVAA- 175 HDD+V V G + S D IKV+ L + + S+RAH + + + Sbjct: 7 DSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWA 66 Query: 176 SPHKDSVFLSCSEDNRILLWDTRCPK-------PASQIGCSAPGYLPTSLAWHPQQSEV- 227 SP + S S D + LW+ + + S+ + P + Sbjct: 67 SPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLK 126 Query: 228 FVFGDENGTVSLVDTKSTSCVLSSA-------------VHSQCVTGLVFSPHS---VPFL 271 +G + L D S + S H Q L + P Sbjct: 127 LACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLA 186 Query: 272 ASLSEDCSLAVL--DSSLSELFRSQAHRDFVRDATWSPLNH---SLLTTVGWDHQVVHHV 326 S E + D L + H+ +R +W+P L+ T D ++ Sbjct: 187 VSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFK 246 Query: 327 VPTEPLPAPGPASVT 341 + + P S+T Sbjct: 247 ITEKLSPLASEESLT 261 Score = 53.6 bits (127), Expect = 1e-07, Method: Composition-based stats. Identities = 41/277 (14%), Positives = 87/277 (31%), Gaps = 37/277 (13%) Query: 80 EAGVADLTWVGE---RGILVASDSGAVELWELDENETLIVSKF-----CKYEHDDIVSTV 131 ++ + + W R I AS V+LWE D ++ + + + +V Sbjct: 57 DSSIVAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSV 116 Query: 132 SVLSS--GTQAVSGSKDICIKVW------DLAQQVVLSSYRA-------HAAQVTCVAAS 176 + G + D ++++ DL + S + H C++ Sbjct: 117 KFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWC 176 Query: 177 PH--KDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQS---EVFVFG 231 P + + I+ + K L S++W P ++ G Sbjct: 177 PSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATG 236 Query: 232 DENGTVSLVDTKSTSCVLSSAVHSQCVTGLVF-SPHSVPFLASLSEDCSLA-----VLDS 285 ++G + + + A +F + V A D + + Sbjct: 237 CKDGRIRIFKITEK--LSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNL 294 Query: 286 SLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQV 322 + L H V +W+ L ++L++ G D +V Sbjct: 295 QVELLSEHDDHNGEVWSVSWN-LTGTILSSAGDDGKV 330 Score = 51.3 bits (121), Expect = 6e-07, Method: Composition-based stats. Identities = 31/212 (14%), Positives = 66/212 (31%), Gaps = 23/212 (10%) Query: 9 LVPPAAREWNLPPNAPACMERQLEAARYRSDGALLLGASS-LSGRCWAGSLWLFKDPCAA 67 L P R W L + A + L S S A S Sbjct: 142 LEPSDLRSWTLTSEMKV---LSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQR 198 Query: 68 PNEGFCSAGVQT---EAGVADLTWVGE-----RGILVASDSGAVELWELDENETLIVSKF 119 +G + ++ + ++W + I G + ++++ E + + S+ Sbjct: 199 GKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEE 258 Query: 120 CKYEHD--DIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQ---VVLSSYRAHAAQVTCVA 174 + D + V + + G S + +L +LS + H +V V+ Sbjct: 259 SLTNSNMFDNSADVDMDAQGR-----SDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVS 313 Query: 175 ASPHKDSVFLSCSEDNRILLWDTRCPKPASQI 206 + ++ S +D ++ LW + Sbjct: 314 WNLT-GTILSSAGDDGKVRLWKATYSNEFKCM 344 >3ACP-A nrPDB Length = 417 Score = 88.3 bits (217), Expect = 4e-18, Method: Composition-based stats. Identities = 44/288 (15%), Positives = 96/288 (33%), Gaps = 40/288 (13%) Query: 77 VQTEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSS 136 + + D + R ++ + G +++ + + N + + H ++ + S Sbjct: 92 KRADYTAVDTAKLQMRRFILGTTEGDIKVLDSNFN----LQREIDQAHVSEITKLKFFPS 147 Query: 137 GTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWD 196 G +S S+D+ +K+W + + H A VT +A +V S S D I LW+ Sbjct: 148 GEALISSSQDMQLKIWSVKDGSNPRTLIGHRATVTDIAIIDRGRNVL-SASLDGTIRLWE 206 Query: 197 TRCPKPASQI-GCSAPGYLPTSLAWHPQQ--------------------SEVFVFGDENG 235 P S+A + + G +G Sbjct: 207 CGTGTTIHTFNRKENPHDGVNSIALFVGTDRQLHEISTSKKNNLEFGTYGKYVIAGHVSG 266 Query: 236 TVSLVDTKST-SCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQ 294 +++ + S + + + L ++ ++ + E+ LA D E + Sbjct: 267 VITVHNVFSKEQTIQLPSKFTCSCNSLTVDGNNANYIYAGYENGMLAQWDLRSPECPVGE 326 Query: 295 AHRDFVRDATWSPLN------HSLLTTVGWDHQVVHHVV--PTEPLPA 334 + P+N +L + G+D + ++ P PA Sbjct: 327 FLINEGT-----PINNVYFAAGALFVSSGFDTSIKLDIISDPESERPA 369 >6F1U-h nrPDB Length = 612 Score = 86.7 bits (213), Expect = 1e-17, Method: Composition-based stats. Identities = 38/258 (14%), Positives = 79/258 (30%), Gaps = 66/258 (25%) Query: 90 GERGILVASDSGAVELWELDENETLIV--SKFCKYEHDDIVSTVSVLSSGT--QAVSGSK 145 ++ + SG + LW+ N+ V + H V V+V+ + +S S Sbjct: 318 HPNLVVGGTYSGQIVLWDNRSNKRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLISIST 377 Query: 146 DICIKVWDLA-------QQVVLSS------------------------------------ 162 D I W L ++ Sbjct: 378 DGKICSWSLDMLSHPQDSMELVHKQSKAVAVTSMSFPVGDVNNFVVGSEEGSVYTACRHG 437 Query: 163 --------YRAHAAQVTCVAASP-----HKDSVFLSCSEDNRILLWDTRCPKPASQIGCS 209 + H +T + +F++ S D + LW T+ KP + Sbjct: 438 SKAGISEMFEGHQGPITGIHCHAAVGAVDFSHLFVTSSFDWTVKLWSTKNNKPLYSFEDN 497 Query: 210 APGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQ---CVTGLVFSPH 266 A + W P +F D G + L + + + V ++++ + + + ++ H Sbjct: 498 AG--YVYDVMWSPTHPALFACVDGMGRLDLWNLNNDTEVPTASISVEGNPALNRVRWT-H 554 Query: 267 SVPFLASLSEDCSLAVLD 284 S +A + + + D Sbjct: 555 SGREIAVGDSEGQIVIYD 572 Score = 67.5 bits (163), Expect = 9e-12, Method: Composition-based stats. Identities = 33/212 (15%), Positives = 60/212 (28%), Gaps = 22/212 (10%) Query: 38 SDGALLLGASSLSGRCWAGSLWLFKDPCAAPNEGFCSAGVQTEAGVADLTWVGERGILVA 97 +DG + + + + A V D+ +V Sbjct: 377 TDGKICSWSLDMLSH-------PQDSMELVHKQSKAVAVTSMSFPVGDV-----NNFVVG 424 Query: 98 SDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVL------SSGTQAVSGSKDICIKV 151 S+ G+V + + + H ++ + V+ S D +K+ Sbjct: 425 SEEGSV--YTACRHGSKAGISEMFEGHQGPITGIHCHAAVGAVDFSHLFVTSSFDWTVKL 482 Query: 152 WDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAP 211 W L S+ +A V V SP ++F R+ LW+ S Sbjct: 483 WSTKNNKPLYSFEDNAGYVYDVMWSPTHPALFACVDGMGRLDLWNLNNDTEVPTASISVE 542 Query: 212 GYLP-TSLAWHPQQSEVFVFGDENGTVSLVDT 242 G + W GD G + + D Sbjct: 543 GNPALNRVRW-THSGREIAVGDSEGQIVIYDV 573 >5OQL-X nrPDB Length = 630 Score = 85.6 bits (210), Expect = 3e-17, Method: Composition-based stats. Identities = 41/273 (15%), Positives = 80/273 (29%), Gaps = 53/273 (19%) Query: 92 RGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKV 151 + ++ + ++ + + + +H D V+ ++ Q S SKD +KV Sbjct: 259 KFVVTGGADKRLVVYNAADLKPIKAF----TQHRDAVTGLAFRRGTNQLYSCSKDRTVKV 314 Query: 152 WDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDT------------RC 199 W L + + + H ++ + A + V + + D W Sbjct: 315 WSLDELAYVETLFGHQDEILDIDALGQERCVSV-GARDRTARYWKVPEESQLVFRGGGEG 373 Query: 200 PKPASQIGCSAPGYLPTSLAW-------HPQQSEVFVFGDENGTVSLVDTKSTSCVLSSA 252 ++ PG P S A ++FV G +NG ++L + + A Sbjct: 374 GSSNTKKHKLPPGMDPASAAHEGSMDRVAMIDDDMFVTGSDNGDLALWSIQRKKPLHVIA 433 Query: 253 VHSQ---------------------------CVTGLVFSPHSVPFLASLSEDCSLAVLDS 285 +T L P+S + S S D + V Sbjct: 434 RAHGLEPPIKLEDYSADEIPDPSIIPAPQPRGITALRTLPYS-DLIFSGSWDGCIRVWRL 492 Query: 286 SL-SELFRSQAHRDFVRDATWSPLNHSLLTTVG 317 S + + + N S T Sbjct: 493 SEDKRKLEAVGILGVGSETCENSTNISNGATSN 525 Score = 71.3 bits (173), Expect = 6e-13, Method: Composition-based stats. Identities = 30/214 (14%), Positives = 59/214 (27%), Gaps = 31/214 (14%) Query: 108 LDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHA 167 + + + H V G V+G D + V++ A + ++ H Sbjct: 229 FAKADARKANDKTYQGHLKAPLVVKASQDGKFVVTGGADKRLVVYNAADLKPIKAFTQHR 288 Query: 168 AQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEV 227 VT +A + SCS+D + +W + A + Q Sbjct: 289 DAVTGLAFR-RGTNQLYSCSKDRTVKVWSLD--ELAYVETLFGHQDEILDID-ALGQERC 344 Query: 228 FVFGDENGTVSLVDTKSTSCVL-----------------------SSAVHSQCVTGLVFS 264 G + T S ++ +SA H + + Sbjct: 345 VSVGARDRTARYWKVPEESQLVFRGGGEGGSSNTKKHKLPPGMDPASAAHEGSMDRVAM- 403 Query: 265 PHSVPFLASLSEDCSLAVLDSSLSELFRS--QAH 296 + S++ LA+ + +AH Sbjct: 404 -IDDDMFVTGSDNGDLALWSIQRKKPLHVIARAH 436 Score = 51.7 bits (122), Expect = 5e-07, Method: Composition-based stats. Identities = 34/168 (20%), Positives = 58/168 (34%), Gaps = 48/168 (28%) Query: 14 AREWNLPPNAPACMERQLEAARYRSDGALLLGASSLSGRCWAGSLWLFKDPCAAPNEGFC 73 AR W +P E ++ G G+S+ + DP +A +EG Sbjct: 354 ARYWKVP-----------EESQLVFRGGGEGGSSNTKKHKLPPGM----DPASAAHEG-- 396 Query: 74 SAGVQTEAGVADLTWVGERGILVASDSGAVELWELDENETLIV----------SKFCKYE 123 + + + + + SD+G + LW + + L V K Y Sbjct: 397 --------SMDRVAMIDDDMFVTGSDNGDLALWSIQRKKPLHVIARAHGLEPPIKLEDYS 448 Query: 124 HDDI-------------VSTVSVLSSGTQAVSGSKDICIKVWDLAQQV 158 D+I ++ + L SGS D CI+VW L++ Sbjct: 449 ADEIPDPSIIPAPQPRGITALRTLPYSDLIFSGSWDGCIRVWRLSEDK 496 >1PI6-A nrPDB Length = 615 Score = 84.4 bits (207), Expect = 7e-17, Method: Composition-based stats. Identities = 50/296 (16%), Positives = 101/296 (34%), Gaps = 28/296 (9%) Query: 41 ALLLGASSLSGRCWAGSLWLFKDPCAAPNEGFCSAGVQTEAG-VADLTWVGE-RGILV-- 96 L G S W W F D + E + Q AG ++D++W E R + V Sbjct: 80 YLCSGDESGKVIVWG---WTF-DKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLCVVG 135 Query: 97 -ASDSGAVEL-WELDENETLIVSKFCKYEHDDIVSTVSVLSSGT-QAVSGSKDICIKVWD 153 D+ V + W+ +L H ++ + S ++++ D + + Sbjct: 136 EGRDNFGVFISWD--SGNSLG----EVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQ 189 Query: 154 ---LAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSA 210 ++ + V V SP ++ D +I +D + + I Sbjct: 190 GPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQ 249 Query: 211 PGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCV--TGLVFSPHSV 268 A S+ F + T+ + D ++ CV + Q + + Sbjct: 250 EPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGN 309 Query: 269 PFLASLSEDCSLAVLDSSLSELFRS-QAHRDFVRDATWSPLNHSLLTTVGWDHQVV 323 + SLS D +L + E+ ++ H + T +P L + +D +++ Sbjct: 310 GRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNP-----LISGSYDGRIM 360 Score = 70.5 bits (171), Expect = 1e-12, Method: Composition-based stats. Identities = 29/209 (13%), Positives = 77/209 (36%), Gaps = 20/209 (9%) Query: 79 TEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGT 138 + G+ L+W+ + + +W++ ++ + K + + V +G Sbjct: 252 VQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNG- 310 Query: 139 QAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTR 198 + +S S D + ++L VL + H +T + +P +S S D RI+ W + Sbjct: 311 RIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNP-----LISGSYDGRIMEWSSS 365 Query: 199 CPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKS---TSCVLSSAVHS 255 + ++ +++ + + T+ + S ++ ++ Sbjct: 366 S---------MHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANN 416 Query: 256 QCVTGLVFSPHSVPFLASLSED--CSLAV 282 T ++ + + L S + D S+ + Sbjct: 417 DGFTAVLTNDDDLLILQSFTGDIIKSVRL 445 Score = 32.4 bits (72), Expect = 0.33, Method: Composition-based stats. Identities = 17/97 (17%), Positives = 32/97 (32%), Gaps = 15/97 (15%) Query: 69 NEGFCSAGVQTEAGVADLTWVG-----------ERGILVASDSGAVELWELDENETLIVS 117 E S + + ++W E + S + ++ + +I Sbjct: 520 REVKTSRWAFRTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKII-- 577 Query: 118 KFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDL 154 H D V+ + + T VS D CIK W++ Sbjct: 578 -KALNAHKDGVNNLLWETPST-LVSSGADACIKRWNV 612 >5A9Q-0 nrPDB Length = 380 Score = 83.6 bits (205), Expect = 1e-16, Method: Composition-based stats. Identities = 48/281 (17%), Positives = 89/281 (31%), Gaps = 37/281 (13%) Query: 76 GVQTEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLS 135 +QT A +W E + G + D C H V + Sbjct: 25 SLQTAETFATGSWDNEENYISLWSIGDFGNLDSDGGFEGDHQLLCDIRHHGDVMDLQFF- 83 Query: 136 SGTQAVSGSKDICIKVW---------DLAQQVVLSSYRAHAAQV---------TCVAASP 177 + V+ S C+ V+ + QQ + Y H T V + Sbjct: 84 DQERIVAASSTGCVTVFLHHPNNQTLSVNQQWTTAHY--HTGPGSPSYSSAPCTGVVCNN 141 Query: 178 HKDSVFLSCSEDNRILLWDTRCPKPASQI--GCSAPGYLPTSLAWHPQQSEVFVFGDENG 235 + ++ ED RI L+ + I S+ + T L + + + G Sbjct: 142 PE---IVTVGEDGRINLFRADHKEAVRTIDNADSSTLHAVTFLR-----TPEILTVNSIG 193 Query: 236 TVSLVDTK----STSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSS--LSE 289 + + D + S +LS + + P+ +A+ +D L++ D Sbjct: 194 QLKIWDFRQQGNEPSQILSLTGDRVPLHCVDRHPNQQHVVATGGQDGMLSIWDVRQGTMP 253 Query: 290 LFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQVVHHVVPTE 330 + +AH + + + P N L T D + H T+ Sbjct: 254 VSLLKAHEAEMWEVHFHPSNPEHLFTCSEDGSLWHWDASTD 294 Score = 81.7 bits (200), Expect = 4e-16, Method: Composition-based stats. Identities = 47/250 (18%), Positives = 91/250 (36%), Gaps = 20/250 (8%) Query: 57 SLWLFKDPCAAPNEG------FCSAGVQTEAGVADLTWVGERGILVASDSGAVELWELD- 109 SLW D ++G ++ V DL + + I+ AS +G V ++ Sbjct: 45 SLWSIGDFGNLDSDGGFEGDHQLLCDIRHHGDVMDLQFFDQERIVAASSTGCVTVFLHHP 104 Query: 110 ENETLIVSKFCKYEHDD------IVSTVSVLS---SGTQAVSGSKDICIKVWDLAQQVVL 160 N+TL V++ H S+ + + V+ +D I ++ + + Sbjct: 105 NNQTLSVNQQWTTAHYHTGPGSPSYSSAPCTGVVCNNPEIVTVGEDGRINLFRADHKEAV 164 Query: 161 SSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTR--CPKPASQIGCSAPGYLPTSL 218 + + + S ++ +WD R +P+ + + + Sbjct: 165 RTIDNADSSTLHAVTFLRTPEILTVNSI-GQLKIWDFRQQGNEPSQILSLTGDRVPLHCV 223 Query: 219 AWHPQQSEVFVFGDENGTVSLVDTKSTS-CVLSSAVHSQCVTGLVFSPHSVPFLASLSED 277 HP Q V G ++G +S+ D + + V H + + F P + L + SED Sbjct: 224 DRHPNQQHVVATGGQDGMLSIWDVRQGTMPVSLLKAHEAEMWEVHFHPSNPEHLFTCSED 283 Query: 278 CSLAVLDSSL 287 SL D+S Sbjct: 284 GSLWHWDAST 293 Score = 77.1 bits (188), Expect = 1e-14, Method: Composition-based stats. Identities = 27/128 (21%), Positives = 47/128 (36%), Gaps = 2/128 (1%) Query: 94 ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAV-SGSKDICIKVW 152 IL + G +++W+ + + V + V +G +D + +W Sbjct: 186 ILTVNSIGQLKIWDFRQQGNEPSQILSLTGDRVPLHCVDRHPNQQHVVATGGQDGMLSIW 245 Query: 153 DLAQQV-VLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAP 211 D+ Q +S +AH A++ V P +CSED + WD P Sbjct: 246 DVRQGTMPVSLLKAHEAEMWEVHFHPSNPEHLFTCSEDGSLWHWDASTDVPEKSSLFHQG 305 Query: 212 GYLPTSLA 219 G T L+ Sbjct: 306 GRSSTFLS 313 Score = 69.4 bits (168), Expect = 2e-12, Method: Composition-based stats. Identities = 32/177 (18%), Positives = 62/177 (35%), Gaps = 11/177 (6%) Query: 90 GERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICI 149 I+ + G + L+ D E + + V+ L + + ++ + + Sbjct: 140 NNPEIVTVGEDGRINLFRADHKEAVRTIDNAD---SSTLHAVTFLRT-PEILTVNSIGQL 195 Query: 150 KVWDLAQQ----VVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPK-PAS 204 K+WD QQ + S + CV P++ V + +D + +WD R P S Sbjct: 196 KIWDFRQQGNEPSQILSLTGDRVPLHCVDRHPNQQHVVATGGQDGMLSIWDVRQGTMPVS 255 Query: 205 QIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGL 261 + + +HP E E+G++ D + SS H + Sbjct: 256 LLKAHEAEMWE--VHFHPSNPEHLFTCSEDGSLWHWDASTDVPEKSSLFHQGGRSST 310 >5BJS-A nrPDB Length = 605 Score = 83.3 bits (204), Expect = 2e-16, Method: Composition-based stats. Identities = 28/197 (14%), Positives = 63/197 (31%), Gaps = 23/197 (11%) Query: 107 ELDENETLIVSKFCKYEHDDIVSTV-SVLS--SGTQAVSGSKDICIKVWDLAQQVVLSSY 163 + D N I+ ++ ++ S + +KV+++ + + + Sbjct: 115 DKDANPCEIIQLIRDDGNEANCASCWSKDPITDQPLLCIAGNEGNVKVYNVTEGKLYRTL 174 Query: 164 RAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDT----RCPKPASQIGCSAPGYLPTSLA 219 H + +A SP + S S+D I +W +G Y S+A Sbjct: 175 VGHGGGINDLATSPANPYIIASASDDTTIRIWSLAPEHEKQPCVCILGGEGHSYDLLSVA 234 Query: 220 WHPQQSEVFVFGDENGTVSLV-------DTKSTSCVLSSAV------HSQCVTGLVFSPH 266 +H V G + ++L + V+ H+ V + F + Sbjct: 235 FHDNGRYVLSAG-HDQVINLWALPEFPNEHMEIPIVIYYPHFSSSEIHNNLVDCVAF--Y 291 Query: 267 SVPFLASLSEDCSLAVL 283 L+ + ++ + Sbjct: 292 GDLILSRACHEDTIVLW 308 Score = 55.5 bits (132), Expect = 4e-08, Method: Composition-based stats. Identities = 32/148 (21%), Positives = 51/148 (34%), Gaps = 22/148 (14%) Query: 70 EGFCSAG-VQTEAGVADLTWV--GERGILVASDSGAVELWEL--DENETLIVSKFCKYEH 124 EG V G+ DL I ASD + +W L + + V H Sbjct: 167 EGKLYRTLVGHGGGINDLATSPANPYIIASASDDTTIRIWSLAPEHEKQPCVCILGGEGH 226 Query: 125 DDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQ------QVVLSSY-------RAHAAQVT 171 + +V+ +G +S D I +W L + ++ + Y H V Sbjct: 227 SYDLLSVAFHDNGRYVLSAGHDQVINLWALPEFPNEHMEIPIVIYYPHFSSSEIHNNLVD 286 Query: 172 CVAASPHKDSVFLS-CSEDNRILLWDTR 198 CVA + LS ++ I+LW Sbjct: 287 CVAF---YGDLILSRACHEDTIVLWRIE 311 >6BX3-B nrPDB Length = 412 Score = 82.9 bits (203), Expect = 2e-16, Method: Composition-based stats. Identities = 43/271 (15%), Positives = 90/271 (33%), Gaps = 28/271 (10%) Query: 60 LFKDPCAAPNE--GFCSAGVQTEAGVADLTWVGERGILV-ASDSGAVELWELDENETLIV 116 L +DP A E + ++ L + L +GA+ ++++D + V Sbjct: 3 LLQDPFAVLKEHPEKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICV 62 Query: 117 SKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAAS 176 H +++++ G ++ S+D IK+WDL++ + + Sbjct: 63 PGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWL 122 Query: 177 PHKDSVFLSC------------SEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQ 224 K + ++ S D L GY+ H + Sbjct: 123 DAKRRLCVATIFEESDAYVIDFSNDPVASL--LSKSDEKQLSSTPDHGYVLVCTV-HTKH 179 Query: 225 SEVFVFGDENGTVSLVDTKS---TSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLA 281 + + G G + S T C+ S + S + L+ S + + S D ++ Sbjct: 180 PNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCS-DRTIR 238 Query: 282 VLDSSL------SELFRSQAHRDFVRDATWS 306 + S+ EL ++D + W+ Sbjct: 239 QYEISIDDENSAVELTLEHKYQDVINKLQWN 269 Score = 40.9 bits (94), Expect = 9e-04, Method: Composition-based stats. Identities = 20/83 (24%), Positives = 30/83 (36%), Gaps = 9/83 (10%) Query: 257 CVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQ-----AHRDFVRDATWSPLNHS 311 L FSP +LA + +L + D AH + WSP + Sbjct: 27 RTECLQFSPCG-DYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSP-DGR 84 Query: 312 LLTTVGWDHQVVHHVV--PTEPL 332 LL T D + + P++PL Sbjct: 85 LLLTSSRDWSIKLWDLSKPSKPL 107 Score = 40.9 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 13/137 (9%), Positives = 45/137 (32%), Gaps = 10/137 (7%) Query: 90 GERGILVASDSGAVELWELD-ENETLIVSKFCKYEHDDIVSTVSVL------SSGTQAVS 142 + + + +E+ ++E V ++++ D+++ + ++ V+ Sbjct: 224 NGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVA 283 Query: 143 ---GSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRC 199 GS + +W+ ++ ++ + + S+ + E + +W Sbjct: 284 STHGSSAHELYIWETTSGTLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWSVVI 343 Query: 200 PKPASQIGCSAPGYLPT 216 P S + Sbjct: 344 PPKWSALAPDFEEVEEN 360 >4OWR-A nrPDB Length = 339 Score = 82.1 bits (201), Expect = 3e-16, Method: Composition-based stats. Identities = 42/255 (16%), Positives = 81/255 (31%), Gaps = 32/255 (12%) Query: 89 VGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDIC 148 + ++ S + V WE+ ++ + H V V G++ + S D Sbjct: 23 LPGNFLIAGSWANDVRCWEVQ--DSGQTIPKAQQMHTGPVLDVCWSDDGSKVFTASCDKT 80 Query: 149 IKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFL-SCSEDNRILLWDTRCPKPASQIG 207 K+WDL+ + H A V + + + + S D + WDTR P + Sbjct: 81 AKMWDLSSNQAIQ-IAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWDTRSSNPMMVLQ 139 Query: 208 CSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKST----SCVLSSAVHSQCVTGLVF 263 Y + + V + + ++ + S H + Sbjct: 140 LPERCYCADVI------YPMAVVATAERGLIVYQLENQPSEFRRIESPLKHQHRCVAIFK 193 Query: 264 SPHSVPF-LASLSEDCSLAVL---------DSSLSELFRSQAHRD-------FVRDATWS 306 + P A S + +A+ D+ + RS V + Sbjct: 194 DKQNKPTGFALGSIEGRVAIHYINPPNPAKDNFTFKCHRSNGTNTSAPQDIYAVNGIAFH 253 Query: 307 PLNHSLLTTVGWDHQ 321 P++ + L TVG D + Sbjct: 254 PVHGT-LATVGSDGR 267 Score = 33.2 bits (74), Expect = 0.16, Method: Composition-based stats. Identities = 10/83 (12%), Positives = 23/83 (27%), Gaps = 4/83 (4%) Query: 109 DENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAA 168 N T + Y V+ ++ + D WD + L + Sbjct: 232 RSNGTNTSAPQDIY----AVNGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQ 287 Query: 169 QVTCVAASPHKDSVFLSCSEDNR 191 ++ + + + + S D Sbjct: 288 PISACCFNHNGNIFAYASSYDWS 310 >2P9P-C nrPDB Length = 372 Score = 81.7 bits (200), Expect = 4e-16, Method: Composition-based stats. Identities = 33/200 (16%), Positives = 70/200 (35%), Gaps = 7/200 (3%) Query: 128 VSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLS--SYRAHAAQVTCVAASPHKDSVFLS 185 +S + TQ + + +++ + + + H QVT V +P + + ++ Sbjct: 11 ISCHAWNKDRTQIAICPNNHEVHIYEKSGNKWVQVHELKEHNGQVTGVDWAPDSNRI-VT 69 Query: 186 CSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFV-FGDENGTVSLVDTKS 244 C D +W + + + W P + + V G ++ + ++ Sbjct: 70 CGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRWAPNEKKFAVGSGSRVISICYFEQEN 129 Query: 245 --TSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHRDFVRD 302 C V L + P+SV LA+ S D + + + E+ A + Sbjct: 130 DWWVCKHIKKPIRSTVLSLDWHPNSV-LLAAGSCDFKCRIFSAYIKEVEERPAPTPWGSK 188 Query: 303 ATWSPLNHSLLTTVGWDHQV 322 + L ++ GW H V Sbjct: 189 MPFGELMFESSSSCGWVHGV 208 Score = 67.5 bits (163), Expect = 8e-12, Method: Composition-based stats. Identities = 40/255 (15%), Positives = 78/255 (30%), Gaps = 27/255 (10%) Query: 87 TWVGERGILVASDSGA-VELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSK 145 W +R + + V ++E N+ + V + EH+ V+ V + V+ Sbjct: 15 AWNKDRTQIAICPNNHEVHIYEKSGNKWVQVHELK--EHNGQVTGVDWAPDSNRIVTCGT 72 Query: 146 DICIKVWDLAQQVVLSSYR--AHAAQVTCVAASPHKDSVFL-SCSEDNRILLWDTRCPKP 202 D VW L + + CV +P++ + S S I ++ Sbjct: 73 DRNAYVWTLKGRTWKPTLVILRINRAARCVRWAPNEKKFAVGSGSRVISICYFEQENDWW 132 Query: 203 ASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDT----KSTSCVLSSAVHS--- 255 + SL WHP + G + + + Sbjct: 133 VCKHIKKPIRSTVLSLDWHPNSV-LLAAGSCDFKCRIFSAYIKEVEERPAPTPWGSKMPF 191 Query: 256 -----------QCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHRDFVRDAT 304 V G+ FS + +A +S D ++ + D+ + A + + Sbjct: 192 GELMFESSSSCGWVHGVCFSANGSR-VAWVSHDSTVCLADADKKMAVATLA-SETLPLLA 249 Query: 305 WSPLNHSLLTTVGWD 319 + + S L G D Sbjct: 250 VTFITESSLVAAGHD 264 >6C0F-s nrPDB Length = 807 Score = 79.4 bits (194), Expect = 2e-15, Method: Composition-based stats. Identities = 40/226 (17%), Positives = 83/226 (36%), Gaps = 28/226 (12%) Query: 76 GVQTEAGVADLTWVGERGILVA----SDSGAVELWELDENETLIVSKFCKYEHDDIVSTV 131 + + V L+W + V S + +V + ++ ++ T K K I+ Sbjct: 590 TISCKKTVKKLSWHRKGDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSK----GIIMDA 645 Query: 132 SVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNR 191 Q S+ ++++DL+QQ+++ A ++ + P D++ S S D R Sbjct: 646 KFHPFKPQLFVCSQ-RYVRIYDLSQQILVKKLLPGARWLSKIDIHPRGDNLIAS-SFDKR 703 Query: 192 ILLWDTR-CPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVS-----LVD--TK 243 +L D P + S+ +H ++ +F ++GT+ + D K Sbjct: 704 VLWHDLDLASTPYKTLRY--HEKAVRSVNFH-KKLPLFSSAADDGTIHVFHATVYDDMMK 760 Query: 244 STSCV--LSSAVHSQ----CVTGLVFSPHSVPFLASLSEDCSLAVL 283 + V H V ++ P +L S D + + Sbjct: 761 NPMIVPLKKLTGHKVINSLGVLDAIWHP-REAWLFSAGADNTARLW 805 Score = 56.3 bits (134), Expect = 2e-08, Method: Composition-based stats. Identities = 37/225 (16%), Positives = 71/225 (31%), Gaps = 36/225 (16%) Query: 123 EHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQ------VTCVAAS 176 H V T+S+ SG +GS D ++VW++ + + + C+ + Sbjct: 435 GHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIECIEWN 494 Query: 177 PHKDSVFLSCSEDNRILL-------WDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFV 229 P ++ L+ + I L +D T + + +E Sbjct: 495 PDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLEVNEN-G 553 Query: 230 FGDENG-----------TVSLVDTKSTS------CVLSSAVHSQCVTGLVFSPHSVPFLA 272 GDE+G V+ + S C+ S + V L + F+ Sbjct: 554 DGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISC--KKTVKKLSWHRKGDYFVT 611 Query: 273 --SLSEDCSLAVLDSSLSELFR-SQAHRDFVRDATWSPLNHSLLT 314 S + S+ + S + + + DA + P L Sbjct: 612 VQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFV 656 Score = 55.9 bits (133), Expect = 2e-08, Method: Composition-based stats. Identities = 23/119 (19%), Positives = 37/119 (31%), Gaps = 17/119 (14%) Query: 92 RGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKV 151 ++ +S V LW + + H+ V +V+ S + D I V Sbjct: 693 DNLIASSFDKRV-LW--HDLDLASTPYKTLRYHEKAVRSVNFHKKLPLFSSAADDGTIHV 749 Query: 152 W------DLAQQ---VVLSSYRAHAA----QVTCVAASPHKDSVFLSCSEDNRILLWDT 197 + D+ + V L H V P + + S DN LW T Sbjct: 750 FHATVYDDMMKNPMIVPLKKLTGHKVINSLGVLDAIWHPRE-AWLFSAGADNTARLWTT 807 Score = 49.4 bits (116), Expect = 2e-06, Method: Composition-based stats. Identities = 23/92 (25%), Positives = 38/92 (41%), Gaps = 13/92 (14%) Query: 246 SCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSL-SELFRSQAHRDF----- 299 C A H V L P + +LA+ S+D ++ V + E++R+ D Sbjct: 428 RCSTIYAGHKGKVRTLSIDPSGL-WLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDY 486 Query: 300 -VRDATWSP--LNHSLLTTVGWDHQVVHHVVP 328 + W+P N L VG + +H +VP Sbjct: 487 HIECIEWNPDANNGILAVAVGEN---IHLIVP 515 Score = 48.2 bits (113), Expect = 5e-06, Method: Composition-based stats. Identities = 35/274 (12%), Positives = 72/274 (26%), Gaps = 44/274 (16%) Query: 94 ILVASDSGAVELWELDEN-ETLIVSKFCKYEHDDI-VSTVSVLSS-GTQAVSGSKDICIK 150 + SD G V +WE+ E + E+ D + + ++ + I Sbjct: 452 LATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIECIEWNPDANNGILAVAVGENIH 511 Query: 151 V-------WDLAQQVVLSSYRAHAAQVTC------VAASPHKDSVFLSCSEDN------- 190 + +D+ + + + D ED Sbjct: 512 LIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLEVNENGD-----GDEDGENESAKN 566 Query: 191 ----RILLWDTRCPKPASQ--IGCSAPGYLPTSLAWHPQQSEVFVFG---DENGTVSLVD 241 ++ W+ K + + L+WH ++ + FV N +V + Sbjct: 567 AVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWH-RKGDYFVTVQPDSGNTSVLIHQ 625 Query: 242 TKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFR--SQAHRDF 299 + F P + + D S L + R + Sbjct: 626 VSKHLTQSPFKKSKGIIMDAKFHPFKPQLFV--CSQRYVRIYDLSQQILVKKLLPGAR-W 682 Query: 300 VRDATWSPLNHSLLTTVGWDHQVVHHVVPTEPLP 333 + P L +D +V+ H + P Sbjct: 683 LSKIDIHP-RGDNLIASSFDKRVLWHDLDLASTP 715 >6EM1-m nrPDB Length = 807 Score = 78.2 bits (191), Expect = 4e-15, Method: Composition-based stats. Identities = 40/226 (17%), Positives = 83/226 (36%), Gaps = 28/226 (12%) Query: 76 GVQTEAGVADLTWVGERGILVA----SDSGAVELWELDENETLIVSKFCKYEHDDIVSTV 131 + + V L+W + V S + +V + ++ ++ T K K I+ Sbjct: 590 TISCKKTVKKLSWHRKGDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSK----GIIMDA 645 Query: 132 SVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNR 191 Q S+ ++++DL+QQ+++ A ++ + P D++ S S D R Sbjct: 646 KFHPFKPQLFVCSQ-RYVRIYDLSQQILVKKLLPGARWLSKIDIHPRGDNLIAS-SFDKR 703 Query: 192 ILLWDTR-CPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVS-----LVD--TK 243 +L D P + S+ +H ++ +F ++GT+ + D K Sbjct: 704 VLWHDLDLASTPYKTLRY--HEKAVRSVNFH-KKLPLFSSAADDGTIHVFHATVYDDMMK 760 Query: 244 STSCV--LSSAVHSQ----CVTGLVFSPHSVPFLASLSEDCSLAVL 283 + V H V ++ P +L S D + + Sbjct: 761 NPMIVPLKKLTGHKVINSLGVLDAIWHPR-EAWLFSAGADNTARLW 805 Score = 55.9 bits (133), Expect = 2e-08, Method: Composition-based stats. Identities = 37/225 (16%), Positives = 71/225 (31%), Gaps = 36/225 (16%) Query: 123 EHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQ------VTCVAAS 176 H V T+S+ SG +GS D ++VW++ + + + C+ + Sbjct: 435 GHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIECIEWN 494 Query: 177 PHKDSVFLSCSEDNRILL-------WDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFV 229 P ++ L+ + I L +D T + + +E Sbjct: 495 PDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLEVNEN-G 553 Query: 230 FGDENG-----------TVSLVDTKSTS------CVLSSAVHSQCVTGLVFSPHSVPFLA 272 GDE+G V+ + S C+ S + V L + F+ Sbjct: 554 DGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISC--KKTVKKLSWHRKGDYFVT 611 Query: 273 SL--SEDCSLAVLDSSLSELFR-SQAHRDFVRDATWSPLNHSLLT 314 S + S+ + S + + + DA + P L Sbjct: 612 VQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFV 656 Score = 55.5 bits (132), Expect = 3e-08, Method: Composition-based stats. Identities = 23/119 (19%), Positives = 37/119 (31%), Gaps = 17/119 (14%) Query: 92 RGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKV 151 ++ +S V LW + + H+ V +V+ S + D I V Sbjct: 693 DNLIASSFDKRV-LW--HDLDLASTPYKTLRYHEKAVRSVNFHKKLPLFSSAADDGTIHV 749 Query: 152 W------DLAQQ---VVLSSYRAHAA----QVTCVAASPHKDSVFLSCSEDNRILLWDT 197 + D+ + V L H V P + + S DN LW T Sbjct: 750 FHATVYDDMMKNPMIVPLKKLTGHKVINSLGVLDAIWHPRE-AWLFSAGADNTARLWTT 807 Score = 49.0 bits (115), Expect = 3e-06, Method: Composition-based stats. Identities = 23/92 (25%), Positives = 38/92 (41%), Gaps = 13/92 (14%) Query: 246 SCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSL-SELFRSQAHRDF----- 299 C A H V L P + +LA+ S+D ++ V + E++R+ D Sbjct: 428 RCSTIYAGHKGKVRTLSIDPSGL-WLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDY 486 Query: 300 -VRDATWSP--LNHSLLTTVGWDHQVVHHVVP 328 + W+P N L VG + +H +VP Sbjct: 487 HIECIEWNPDANNGILAVAVGEN---IHLIVP 515 Score = 47.4 bits (111), Expect = 8e-06, Method: Composition-based stats. Identities = 35/274 (12%), Positives = 72/274 (26%), Gaps = 44/274 (16%) Query: 94 ILVASDSGAVELWELDEN-ETLIVSKFCKYEHDDI-VSTVSVLSS-GTQAVSGSKDICIK 150 + SD G V +WE+ E + E+ D + + ++ + I Sbjct: 452 LATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIECIEWNPDANNGILAVAVGENIH 511 Query: 151 V-------WDLAQQVVLSSYRAHAAQVTC------VAASPHKDSVFLSCSEDN------- 190 + +D+ + + + D ED Sbjct: 512 LIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLEVNENGD-----GDEDGENESAKN 566 Query: 191 ----RILLWDTRCPKPASQ--IGCSAPGYLPTSLAWHPQQSEVFVFG---DENGTVSLVD 241 ++ W+ K + + L+WH ++ + FV N +V + Sbjct: 567 AVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWH-RKGDYFVTVQPDSGNTSVLIHQ 625 Query: 242 TKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFR--SQAHRDF 299 + F P + + D S L + R + Sbjct: 626 VSKHLTQSPFKKSKGIIMDAKFHPFKPQLFV--CSQRYVRIYDLSQQILVKKLLPGAR-W 682 Query: 300 VRDATWSPLNHSLLTTVGWDHQVVHHVVPTEPLP 333 + P L +D +V+ H + P Sbjct: 683 LSKIDIHP-RGDNLIASSFDKRVLWHDLDLASTP 715 >6CB1-s nrPDB Length = 569 Score = 78.2 bits (191), Expect = 5e-15, Method: Composition-based stats. Identities = 40/226 (17%), Positives = 83/226 (36%), Gaps = 28/226 (12%) Query: 76 GVQTEAGVADLTWVGERGILVA----SDSGAVELWELDENETLIVSKFCKYEHDDIVSTV 131 + + V L+W + V S + +V + ++ ++ T K K I+ Sbjct: 352 TISCKKTVKKLSWHRKGDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSK----GIIMDA 407 Query: 132 SVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNR 191 Q S+ ++++DL+QQ+++ A ++ + P D++ S S D R Sbjct: 408 KFHPFKPQLFVCSQ-RYVRIYDLSQQILVKKLLPGARWLSKIDIHPRGDNLIAS-SFDKR 465 Query: 192 ILLWDTR-CPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVS-----LVD--TK 243 +L D P + S+ +H ++ +F ++GT+ + D K Sbjct: 466 VLWHDLDLASTPYKTLRY--HEKAVRSVNFH-KKLPLFSSAADDGTIHVFHATVYDDMMK 522 Query: 244 STSCV--LSSAVHSQ----CVTGLVFSPHSVPFLASLSEDCSLAVL 283 + V H V ++ P +L S D + + Sbjct: 523 NPMIVPLKKLTGHKVINSLGVLDAIWHPR-EAWLFSAGADNTARLW 567 Score = 55.9 bits (133), Expect = 3e-08, Method: Composition-based stats. Identities = 37/225 (16%), Positives = 71/225 (31%), Gaps = 36/225 (16%) Query: 123 EHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQ------VTCVAAS 176 H V T+S+ SG +GS D ++VW++ + + + C+ + Sbjct: 197 GHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIECIEWN 256 Query: 177 PHKDSVFLSCSEDNRILL-------WDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFV 229 P ++ L+ + I L +D T + + +E Sbjct: 257 PDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLEVNEN-G 315 Query: 230 FGDENG-----------TVSLVDTKSTS------CVLSSAVHSQCVTGLVFSPHSVPFLA 272 GDE+G V+ + S C+ S + V L + F+ Sbjct: 316 DGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISC--KKTVKKLSWHRKGDYFVT 373 Query: 273 SL--SEDCSLAVLDSSLSELFR-SQAHRDFVRDATWSPLNHSLLT 314 S + S+ + S + + + DA + P L Sbjct: 374 VQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFV 418 Score = 55.5 bits (132), Expect = 3e-08, Method: Composition-based stats. Identities = 23/119 (19%), Positives = 37/119 (31%), Gaps = 17/119 (14%) Query: 92 RGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKV 151 ++ +S V LW + + H+ V +V+ S + D I V Sbjct: 455 DNLIASSFDKRV-LW--HDLDLASTPYKTLRYHEKAVRSVNFHKKLPLFSSAADDGTIHV 511 Query: 152 W------DLAQQ---VVLSSYRAHAA----QVTCVAASPHKDSVFLSCSEDNRILLWDT 197 + D+ + V L H V P + + S DN LW T Sbjct: 512 FHATVYDDMMKNPMIVPLKKLTGHKVINSLGVLDAIWHPRE-AWLFSAGADNTARLWTT 569 Score = 48.6 bits (114), Expect = 4e-06, Method: Composition-based stats. Identities = 23/92 (25%), Positives = 38/92 (41%), Gaps = 13/92 (14%) Query: 246 SCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSL-SELFRSQAHRDF----- 299 C A H V L P + +LA+ S+D ++ V + E++R+ D Sbjct: 190 RCSTIYAGHKGKVRTLSIDPSGL-WLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDY 248 Query: 300 -VRDATWSP--LNHSLLTTVGWDHQVVHHVVP 328 + W+P N L VG + +H +VP Sbjct: 249 HIECIEWNPDANNGILAVAVGEN---IHLIVP 277 Score = 47.0 bits (110), Expect = 1e-05, Method: Composition-based stats. Identities = 35/274 (12%), Positives = 72/274 (26%), Gaps = 44/274 (16%) Query: 94 ILVASDSGAVELWELDEN-ETLIVSKFCKYEHDDI-VSTVSVLSS-GTQAVSGSKDICIK 150 + SD G V +WE+ E + E+ D + + ++ + I Sbjct: 214 LATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIECIEWNPDANNGILAVAVGENIH 273 Query: 151 V-------WDLAQQVVLSSYRAHAAQVTC------VAASPHKDSVFLSCSEDN------- 190 + +D+ + + + D ED Sbjct: 274 LIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLEVNENGD-----GDEDGENESAKN 328 Query: 191 ----RILLWDTRCPKPASQ--IGCSAPGYLPTSLAWHPQQSEVFVFG---DENGTVSLVD 241 ++ W+ K + + L+WH ++ + FV N +V + Sbjct: 329 AVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWH-RKGDYFVTVQPDSGNTSVLIHQ 387 Query: 242 TKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFR--SQAHRDF 299 + F P + + D S L + R + Sbjct: 388 VSKHLTQSPFKKSKGIIMDAKFHPFKPQLFV--CSQRYVRIYDLSQQILVKKLLPGAR-W 444 Query: 300 VRDATWSPLNHSLLTTVGWDHQVVHHVVPTEPLP 333 + P L +D +V+ H + P Sbjct: 445 LSKIDIHP-RGDNLIASSFDKRVLWHDLDLASTP 477 >3JZG-A nrPDB Length = 402 Score = 74.8 bits (182), Expect = 5e-14, Method: Composition-based stats. Identities = 32/224 (14%), Positives = 73/224 (32%), Gaps = 25/224 (11%) Query: 90 GERGILVASDSGAVELWELDE-NETLIVSKFCKYEHDDIVSTVSVLSSGT----QAVSGS 144 G+ + S V L+E E ++ + + D+ T + Sbjct: 69 GDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAG 128 Query: 145 KDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPAS 204 I++ + + Y H + + P ++ LS S+D+ + LW+ + + Sbjct: 129 SRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVA 188 Query: 205 QIGC-SAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVF 263 G S + ++ G + ++ L S + + + Sbjct: 189 IFGGVEGHRDEVLSADYDLLGEKIMSCG-MDHSLKLWRINSKRMMNAIKE------SYDY 241 Query: 264 SPHSV--PFLASLSEDCSLAVLDSSLSELFRSQAHRDFVRDATW 305 +P+ PF++ + D S ++ HR++V W Sbjct: 242 NPNKTNRPFIS-----QKIHFPDFSTRDI-----HRNYVDCVRW 275 Score = 42.4 bits (98), Expect = 3e-04, Method: Composition-based stats. Identities = 23/127 (18%), Positives = 47/127 (37%), Gaps = 10/127 (7%) Query: 218 LAWHPQQSEVFVFGD-ENGTVSLVDTKSTSCVLSSAVHSQCVTGLVF--------SPHSV 268 WH ++ + VF + V+L + S + + F S S Sbjct: 62 FNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSH 121 Query: 269 PFLASLSEDCSLAVLDSSLSELFR-SQAHRDFVRDATWSPLNHSLLTTVGWDHQVVHHVV 327 P LA + +++ + + H + + + + P + +LL +V DH + + Sbjct: 122 PLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNI 181 Query: 328 PTEPLPA 334 T+ L A Sbjct: 182 QTDTLVA 188 >5YZG-2 nrPDB Length = 646 Score = 74.0 bits (180), Expect = 8e-14, Method: Composition-based stats. Identities = 39/235 (16%), Positives = 76/235 (32%), Gaps = 34/235 (14%) Query: 83 VADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVS 142 + + I+ AS G V+ W+ E V F H ++ +++V S G S Sbjct: 93 ITHVVCTKTDFIITASHDGHVKFWKKIEEGIEFVKHFR--SHLGVIESIAVSSEGALFCS 150 Query: 143 GSKDICIKVWDLAQQVVLSSYR-----AHAAQVTCVAASPHK--DSVFLSCSEDNRILLW 195 D +KV+D+ +++ + + C P SV S +I ++ Sbjct: 151 VGDDKAMKVFDVVNFDMINMLKLGYFPGQCEWIYC----PGDAISSVAASEKSTGKIFIY 206 Query: 196 DTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSL---------------- 239 D R I T + +P + + + Sbjct: 207 DGRGDNQPLHIFDKLHTSPLTQIRLNPVYK---AVVSSDKSGMIEYWTGPPHEYKFPKNV 263 Query: 240 -VDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRS 293 + K+ + + A T + FSP +A++ D + + +L R Sbjct: 264 NWEYKTDTDLYEFAKCKAYPTSVCFSPDGKK-IATIGSDRKVRIFRFVTGKLMRV 317 Score = 42.4 bits (98), Expect = 3e-04, Method: Composition-based stats. Identities = 18/130 (13%), Positives = 35/130 (26%), Gaps = 16/130 (12%) Query: 95 LVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKV--- 151 + AS+ +++ D H ++ + + VS K I+ Sbjct: 193 VAASEKSTGKIFIYDGRGDNQPLHIFDKLHTSPLTQIRLNPVYKAVVSSDKSGMIEYWTG 252 Query: 152 ------------WDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRC 199 W+ L + A T V SP + D ++ ++ Sbjct: 253 PPHEYKFPKNVNWEYKTDTDLYEFAKCKAYPTSVCFSPD-GKKIATIGSDRKVRIFRFVT 311 Query: 200 PKPASQIGCS 209 K S Sbjct: 312 GKLMRVFDES 321 >3JB9-S nrPDB Length = 488 Score = 72.8 bits (177), Expect = 2e-13, Method: Composition-based stats. Identities = 33/212 (15%), Positives = 80/212 (37%), Gaps = 10/212 (4%) Query: 71 GFCSAGVQTEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVST 130 G ++ + + V L L+A+ + ++ L V +H +++ Sbjct: 286 GEPTSSIPIDEKVNFLQAHPSGEYLLAASNEKCYIFSLKS----QVYNITVAQH---ITS 338 Query: 131 VSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDN 190 ++V G V+G ++ ++ ++ + L+ + H++ V + + + ++ ++D+ Sbjct: 339 LAVHPDGNLFVAGLENGELRFFETSSGNELTKFGPHSSPVKTLQFGENGYWLVVTTNDDS 398 Query: 191 RILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLS 250 I +WD R + +I +++ + E V + S S Sbjct: 399 DIFIWDLRKSELVQKIPLQT---KVAAVSLDITSQLLVSSDGETLYVHIYVKSSKSWRCM 455 Query: 251 SAVHSQCVTGLVFSPHSVPFLASLSEDCSLAV 282 S H ++ LV+ L S S L + Sbjct: 456 SQTHVSSISNLVWLNELHQLLFSTSNGAILRL 487 Score = 61.7 bits (148), Expect = 4e-10, Method: Composition-based stats. Identities = 32/161 (19%), Positives = 63/161 (39%), Gaps = 11/161 (6%) Query: 167 AAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSE 226 +V + A P + + + +E + ++ + + TSLA HP Sbjct: 295 DEKVNFLQAHPSGEYLLAASNE--KCYIFSLKSQVYNITVAQH-----ITSLAVHP-DGN 346 Query: 227 VFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSS 286 +FV G ENG + +T S + + HS V L F + + + ++D + + D Sbjct: 347 LFVAGLENGELRFFETSSGNELTKFGPHSSPVKTLQFGENGYWLVVTTNDDSDIFIWDLR 406 Query: 287 LSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQVVHHVV 327 SEL + + V L+ + V D + ++ + Sbjct: 407 KSELVQKIPLQTKVAAV---SLDITSQLLVSSDGETLYVHI 444 >4E5Z-B nrPDB Length = 436 Score = 70.9 bits (172), Expect = 7e-13, Method: Composition-based stats. Identities = 50/320 (15%), Positives = 102/320 (31%), Gaps = 45/320 (14%) Query: 32 EAARYRSDGALLLGASSLSGRCWAGS------LWLFKDPCAAPNEGFCSAGVQTEAGVAD 85 +AA + L + GS LW F ++ G+ + Sbjct: 114 KAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNF----GIKDKPTFIKGIGAGGSITG 169 Query: 86 LTW--VGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVS----TVSVLSSGTQ 139 L + + +S G L + N + D ++ ++ V +S Sbjct: 170 LKFNPLNTNQFYASSMEGTTRLQDFKGN------ILRVFASSDTINIWFCSLDVSASSRM 223 Query: 140 AVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRC 199 V+G + + ++ L + R H +VT VA +P D + S D + +WD R Sbjct: 224 VVTGDNVGNVILLNMD-GKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQ 282 Query: 200 PKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSC----VLSSAVHS 255 + + S P P + A + D+ + + C + H Sbjct: 283 VRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHF 342 Query: 256 QCVT--GLVFSPHSVPFLASLSED-----------CSLAVLDSSLSELFRSQAHRDFVRD 302 Q +T + P + D ++ V D + ++ Q + Sbjct: 343 QHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMC-QLYDPESSG 401 Query: 303 A----TWSPLNHSLLTTVGW 318 ++P+ +L + +G+ Sbjct: 402 ISSLNEFNPMGDTLASAMGY 421 Score = 67.5 bits (163), Expect = 7e-12, Method: Composition-based stats. Identities = 42/209 (20%), Positives = 63/209 (30%), Gaps = 47/209 (22%) Query: 154 LAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGY 213 L +L + T +A P S S+ I+LW+ + I G Sbjct: 106 LDSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGG 165 Query: 214 LPTSLAWHPQQSEVFVFGDENGTVSLVDTK------------------------------ 243 T L ++P + F GT L D K Sbjct: 166 SITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVV 225 Query: 244 -------------STSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSE- 289 + + +H + VT + +P FLA+ S D ++ + D Sbjct: 226 TGDNVGNVILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRG 285 Query: 290 ---LFRSQAHRDFVRDATWSPLNHSLLTT 315 S HR V A +SP LLTT Sbjct: 286 KASFLYSLPHRHPVNAACFSPDGARLLTT 314 >5TF2-A nrPDB Length = 407 Score = 70.9 bits (172), Expect = 8e-13, Method: Composition-based stats. Identities = 35/230 (15%), Positives = 75/230 (32%), Gaps = 35/230 (15%) Query: 131 VSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDN 190 V T +G D ++VW + + ++AH ++ +A P ++ D Sbjct: 178 VCFNHDNTLLATGGTDGYVRVWKVPSLEKVLEFKAHEGEIEDLALGPDG--KLVTVGRDL 235 Query: 191 RILLWDTRCPKPASQIGCSAPGYLPTSLAW----------HPQQSEVFVFGDENGTVSL- 239 + +W + P + T + P +F + + Sbjct: 236 KASVWQKDQLVTQLHWQENGPTFSSTPYRYQACRFGQVPDQPAGLRLFTVQIPHKRLRQP 295 Query: 240 -------VDTKSTSCVLSSA-VHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSEL- 290 D + + + + H V+ L S FL + S+A+ + + Sbjct: 296 PPCYLTAWDGSNFLPLRTKSCGHE-VVSCLDVSESGT-FLGLGTVTGSVAIYIAFSLQCL 353 Query: 291 -FRSQAHRDFVRDATWSPL----------NHSLLTTVGWDHQVVHHVVPT 329 + +AH V D + P + + L +V D + H++P+ Sbjct: 354 YYVREAHGIVVTDVAFLPEKGRGPELLGSHETALFSVAVDSRCQLHLLPS 403 Score = 49.4 bits (116), Expect = 2e-06, Method: Composition-based stats. Identities = 19/115 (16%), Positives = 33/115 (28%), Gaps = 15/115 (13%) Query: 218 LAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSED 277 + + + G +G V + S VL H + L P L ++ D Sbjct: 177 VVCFNHDNTLLATGGTDGYVRVWKVPSLEKVLEFKAHEGEIEDLALGPDGK--LVTVGRD 234 Query: 278 CSLAVLDSSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQ-VVHHVVPTEP 331 +V V W N ++ + +Q VP +P Sbjct: 235 LKASVWQK-----------DQLVTQLHWQ-ENGPTFSSTPYRYQACRFGQVPDQP 277 Score = 39.7 bits (91), Expect = 0.002, Method: Composition-based stats. Identities = 11/74 (14%), Positives = 22/74 (29%), Gaps = 4/74 (5%) Query: 167 AAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSE 226 + + V H +++ + D + +W P + A LA P Sbjct: 171 SDPLQKVVCFNHDNTLLATGGTDGYVRVWKV--PSLEKVLEFKAHEGEIEDLALGPDGK- 227 Query: 227 VFVFGDENGTVSLV 240 V + S+ Sbjct: 228 -LVTVGRDLKASVW 240 >5OV3-A nrPDB Length = 381 Score = 69.4 bits (168), Expect = 2e-12, Method: Composition-based stats. Identities = 33/162 (20%), Positives = 57/162 (35%), Gaps = 6/162 (3%) Query: 130 TVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSED 189 T + GT G D I +WD + + AH V + S +S S D Sbjct: 30 TCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWS-RDGHKLVSASTD 88 Query: 190 NRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQ-SEVFVFGDENGTVSLVDTKSTSCV 248 N + WD + +P + +HP+ ++V V ++ V L + S V Sbjct: 89 NIVSQWDVLSGDCDQRFRFPSP---ILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVV 145 Query: 249 LSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSEL 290 L S F ++ + + + VL + +L Sbjct: 146 LPVDDDSDLNVVASFDRRGE-YIYTGNAKGKILVLKTDSQDL 186 Score = 69.0 bits (167), Expect = 3e-12, Method: Composition-based stats. Identities = 31/199 (15%), Positives = 64/199 (32%), Gaps = 13/199 (6%) Query: 93 GILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVW 152 + V + G + +W+ + H V ++ G + VS S D + W Sbjct: 39 LLAVGCNDGRIVIWDFLTRGIAKIIS----AHIHPVCSLCWSRDGHKLVSASTDNIVSQW 94 Query: 153 DLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPG 212 D+ +R + + V P + L C + ++ + Sbjct: 95 DVLSGDCDQRFRF-PSPILKVQYHPRDQNKVLVCPMKSAPVM--LTLSDSKHVVLPVDDD 151 Query: 213 YLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSS-----AVHSQCVTGLVFSPHS 267 +A ++ E G+ G + ++ T S V S ++ + + F+ Sbjct: 152 SDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKG 211 Query: 268 VPFLASLSEDCSLAVLDSS 286 FL + D + V D Sbjct: 212 SCFLINT-ADRIIRVYDGR 229 Score = 56.3 bits (134), Expect = 2e-08, Method: Composition-based stats. Identities = 14/95 (14%), Positives = 31/95 (32%), Gaps = 7/95 (7%) Query: 225 SEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLD 284 + G +G + + D + + H V L +S + S S D ++ D Sbjct: 37 GTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLV-SASTDNIVSQWD 95 Query: 285 SSLS---ELFRSQAHRDFVRDATWSPLNHSLLTTV 316 + FR + + + P + + + Sbjct: 96 VLSGDCDQRFRFPS---PILKVQYHPRDQNKVLVC 127 >3EI3-B nrPDB Length = 383 Score = 68.2 bits (165), Expect = 5e-12, Method: Composition-based stats. Identities = 32/205 (15%), Positives = 65/205 (31%), Gaps = 9/205 (4%) Query: 128 VSTVSVLSSG-TQAVSGSKDICIKVW--DLAQQVVLSSYRAHAAQVTCVAASPHKDSVFL 184 V+++ + T GSK I +W D+ + +T + + + Sbjct: 76 VTSLEWHPTHPTTVAVGSKGGDIILWDYDVQNKTSFIQGMGPGDAITGMKFNQFNTNQLF 135 Query: 185 SCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKS 244 S L D + Y + ++ GD G + L Sbjct: 136 VSSIRGATTLRDFSGSVIQVFAKTDSWDYWYCCVD-VSVSRQMLATGDSTGRLLL-LGLD 193 Query: 245 TSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSL----SELFRSQAHRDFV 300 + +H VT F+P +A+ S D ++ + D + H V Sbjct: 194 GHEIFKEKLHKAKVTHAEFNPRCDWLMATSSVDATVKLWDLRNIKDKNSYIAEMPHEKPV 253 Query: 301 RDATWSPLNHSLLTTVGWDHQVVHH 325 A ++P + + L T +++ + Sbjct: 254 NAAYFNPTDSTKLLTTDQRNEIRVY 278 Score = 64.8 bits (156), Expect = 5e-11, Method: Composition-based stats. Identities = 42/272 (15%), Positives = 79/272 (29%), Gaps = 61/272 (22%) Query: 80 EAGVADLTW--VGERGILVASDSGAVELWELD-ENETLIVSKFCKYEHDDIVSTVSVLSS 136 + V L W + V S G + LW+ D +N+T + D ++ + Sbjct: 73 DRRVTSLEWHPTHPTTVAVGSKGGDIILWDYDVQNKTSFIQGM---GPGDAITGMKFNQF 129 Query: 137 GT-QAVSGSKDICIKVWDLAQQVVLSSY-------------------------------- 163 T Q S + D V+ + Sbjct: 130 NTNQLFVSSIRGATTLRDF-SGSVIQVFAKTDSWDYWYCCVDVSVSRQMLATGDSTGRLL 188 Query: 164 ------------RAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPA-SQIGCSA 210 + H A+VT +P D + + S D + LWD R K S I Sbjct: 189 LLGLDGHEIFKEKLHKAKVTHAEFNPRCDWLMATSSVDATVKLWDLRNIKDKNSYIAEMP 248 Query: 211 PGYLPTSLAWHPQQSEVFVFGDENGTVSL---VDTKSTSCVLSSAV----HSQCVTGLVF 263 + ++P S + D+ + + D ++ H + + Sbjct: 249 HEKPVNAAYFNPTDSTKLLTTDQRNEIRVYSSYDWSKPDQIIIHPHRQFQHLTPIKAT-W 307 Query: 264 SPHSVPFLASLSEDCSLAVLDSSLSELFRSQA 295 P +A D L + D +++ + + Sbjct: 308 HPMYDLIVAGRYPDDQLLLNDKRTIDIYDANS 339 >5K19-A nrPDB Length = 569 Score = 67.8 bits (164), Expect = 6e-12, Method: Composition-based stats. Identities = 33/195 (16%), Positives = 63/195 (32%), Gaps = 28/195 (14%) Query: 80 EAGVADLTWVG--ERGILVASDSGAVELWELDE--NETLIVSKFCKYEHDDIVSTVSVLS 135 ++ V + WV E LVA SG + L+ ++ T + K V T S Sbjct: 149 KSRVTCVKWVPGSESLFLVAHSSGNMYLYNVEHTCGTTAPHYQLLKQGESFAVHTCKSKS 208 Query: 136 SGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLW 195 + + W + + + A SP S+D + ++ Sbjct: 209 TRNPLLK---------WTVGEGAL-----------NEFAFSPD-GKFLACVSQDGFLRVF 247 Query: 196 DTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHS 255 + + + G L + W P + V G E+ V++ + H Sbjct: 248 NFDSVELHGTMKSYFGGLL--CVCWSP-DGKYIVTGGEDDLVTVWSFVDCRVIARGHGHK 304 Query: 256 QCVTGLVFSPHSVPF 270 V+ + F P++ Sbjct: 305 SWVSVVAFDPYTTSV 319 Score = 65.1 bits (157), Expect = 4e-11, Method: Composition-based stats. Identities = 33/199 (16%), Positives = 63/199 (31%), Gaps = 26/199 (13%) Query: 80 EAGVADLTWVGERGILV-ASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGT 138 E + + + + L S G + ++ D E + + V G Sbjct: 220 EGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVE----LHGTMKSYFGGLLCVCWSPDGK 275 Query: 139 QAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSV-------FLSCSEDNR 191 V+G +D + VW V++ H + V+ VA P+ SV F ED + Sbjct: 276 YIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQ 335 Query: 192 ILLW---DTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKST--- 245 LL D + ++ P S+ + F ++ + L D Sbjct: 336 DLLHFGRDRANSTQSRLSKRNSTDSRPVSVTYR------FGSVGQDTQLCLWDLTEDILF 389 Query: 246 --SCVLSSAVHSQCVTGLV 262 + + H+ + Sbjct: 390 PHQPLSRARTHTNVMNATS 408 Score = 64.8 bits (156), Expect = 6e-11, Method: Composition-based stats. Identities = 24/172 (13%), Positives = 54/172 (31%), Gaps = 27/172 (15%) Query: 167 AAQVTCVAASPHKDSVFLSCSEDNRILLWDTRC--------------PKPASQIGCSAPG 212 ++VTCV P +S+FL + L++ + + C + Sbjct: 149 KSRVTCVKWVPGSESLFLVAHSSGNMYLYNVEHTCGTTAPHYQLLKQGESFAVHTCKSKS 208 Query: 213 YLPTSLAW-----------HPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGL 261 L W + ++G + + + S + + + + Sbjct: 209 TRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCV 268 Query: 262 VFSPHSVPFLASLSEDCSLAVLD-SSLSELFRSQAHRDFVRDATWSPLNHSL 312 +SP ++ + ED + V + R H+ +V + P S+ Sbjct: 269 CWSPDG-KYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSV 319 >3I2N-A nrPDB Length = 357 Score = 67.8 bits (164), Expect = 7e-12, Method: Composition-based stats. Identities = 38/223 (17%), Positives = 73/223 (32%), Gaps = 38/223 (17%) Query: 94 ILVASDSGAVELWELDENETLIVSKFCKYEHDDI-VSTVSV----LSSGTQAVSGSKDIC 148 I+ S G V++W+ + + + + + TV+ +G + Sbjct: 132 IVTGSRDGTVKVWDPRQKDDPVANMEPVQGENKRDCWTVAFGNAYNQEERVVCAGYDNGD 191 Query: 149 IKVWDLAQQVVLSSYRAHAA---QVTCVAASPHKDSV--FLSCSEDNRILLWDTRCPKPA 203 IK++DL R V + S+ ++ S + + ++D R P Sbjct: 192 IKLFDLRNMA----LRWETNIKNGVCSLEFDRKDISMNKLVATSLEGKFHVFDMRTQHPT 247 Query: 204 SQIGCSAPGYLPTSLAWH----PQQSEVFVFGDENGTVSLVDTK---------------- 243 S S W PQ E+F+ G + L + Sbjct: 248 KGFA-SVSEKAHKSTVWQVRHLPQNRELFLTAGGAGGLHLWKYEYPIQRSKKDSEGIEMG 306 Query: 244 ---STSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVL 283 S S + + + +Q ++ L +SP S D ++ VL Sbjct: 307 VAGSVSLLQNVTLSTQPISSLDWSPDKRGLCVCSSFDQTVRVL 349 Score = 64.0 bits (154), Expect = 8e-11, Method: Composition-based stats. Identities = 40/291 (13%), Positives = 81/291 (27%), Gaps = 47/291 (16%) Query: 73 CSAGVQTEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVS 132 + G T + +R + G + +W L E + + H +I++ + Sbjct: 62 IEKAKPIKCGTFGATSLQQRYLATGDFGGNLHIWNL---EAPEMPVYSVKGHKEIINAID 118 Query: 133 VLSS------GTQAVSGSKDICIKVWDLAQQ-VVLSSYRA----HAAQVTCVAASP--HK 179 + + V+GS+D +KVWD Q+ +++ + VA ++ Sbjct: 119 GIGGLGIGEGAPEIVTGSRDGTVKVWDPRQKDDPVANMEPVQGENKRDCWTVAFGNAYNQ 178 Query: 180 DSVFLSCSED-NRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEV--FVFGDENGT 236 + + D I L+D R + + SL + + + V G Sbjct: 179 EERVVCAGYDNGDIKLFDLRN---MALRWETNIKNGVCSLEFDRKDISMNKLVATSLEGK 235 Query: 237 VSLVDTKSTSCVLSS-----AVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELF 291 + D ++ H V + P + + L + Sbjct: 236 FHVFDMRTQHPTKGFASVSEKAHKSTVWQVRHLPQNRELFLTAGGAGGLHLWKYEYPIQR 295 Query: 292 RSQAHRDFVRDAT--------------------WSPLNHSLLTTVGWDHQV 322 + WSP L +D V Sbjct: 296 SKKDSEGIEMGVAGSVSLLQNVTLSTQPISSLDWSPDKRGLCVCSSFDQTV 346 Score = 38.6 bits (88), Expect = 0.004, Method: Composition-based stats. Identities = 16/141 (11%), Positives = 39/141 (27%), Gaps = 25/141 (17%) Query: 79 TEAGVADLTWVGER----GILVASDSGAVELWELDENETLIVS-KFCKYEHDDIVSTVSV 133 + GV L + + ++ S G ++++ + H V V Sbjct: 208 IKNGVCSLEFDRKDISMNKLVATSLEGKFHVFDMRTQHPTKGFASVSEKAHKSTVWQVRH 267 Query: 134 LSSGT-QAVSGSKDICIKVWDLA-------------------QQVVLSSYRAHAAQVTCV 173 L ++ + +W +L + ++ + Sbjct: 268 LPQNRELFLTAGGAGGLHLWKYEYPIQRSKKDSEGIEMGVAGSVSLLQNVTLSTQPISSL 327 Query: 174 AASPHKDSVFLSCSEDNRILL 194 SP K + + S D + + Sbjct: 328 DWSPDKRGLCVCSSFDQTVRV 348 >5CXB-B nrPDB Length = 369 Score = 67.5 bits (163), Expect = 7e-12, Method: Composition-based stats. Identities = 25/173 (14%), Positives = 58/173 (33%), Gaps = 19/173 (10%) Query: 125 DDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFL 184 + + T S ++ I+ +DL + ++ + A ++ P D++ + Sbjct: 201 NGLAQTASFHPLRPLFFVATQ-RSIRCYDLQKLELVKIVQPGAKWISSFDVHPGGDNLVV 259 Query: 185 SCSEDNRILLWDTR-CPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTK 243 S D R+L D +P + ++ +H +F ++G++ + K Sbjct: 260 -GSYDKRLLWHDLDLSNRPYKTMRF--HTEAIRAVRFHKGGLPLFADASDDGSLQIFHGK 316 Query: 244 STS---------CVLSSAVHSQ----CVTGLVFSPHSVPFLASLSEDCSLAVL 283 + V H V + + P P+ S D + + Sbjct: 317 VPNDQLENPTIVPVKMLKGHKVVNKLGVLDIDWHPR-EPWCVSAGADGTARLW 368 Score = 65.9 bits (159), Expect = 2e-11, Method: Composition-based stats. Identities = 34/219 (15%), Positives = 65/219 (29%), Gaps = 36/219 (16%) Query: 128 VSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQV-----TCVA----ASPH 178 + +S G + S V + + H Q+ +A P Sbjct: 159 IKAISWHRRGDHFATVSPSGQ------RSSVAIHTLSKHLTQIPFRKLNGLAQTASFHPL 212 Query: 179 KDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVS 238 + F++ I +D + + + A +S HP + V G + + Sbjct: 213 RPLFFVATQ--RSIRCYDLQKLELVKIVQPGAK--WISSFDVHP-GGDNLVVGSYDKRLL 267 Query: 239 LVDT-KSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSS----------L 287 D S + H++ + + F +P A S+D SL + + Sbjct: 268 WHDLDLSNRPYKTMRFHTEAIRAVRFHKGGLPLFADASDDGSLQIFHGKVPNDQLENPTI 327 Query: 288 SELFRSQAHRDF----VRDATWSPLNHSLLTTVGWDHQV 322 + + H+ V D W P + G D Sbjct: 328 VPVKMLKGHKVVNKLGVLDIDWHPRE-PWCVSAGADGTA 365 Score = 56.7 bits (135), Expect = 1e-08, Method: Composition-based stats. Identities = 39/265 (14%), Positives = 76/265 (28%), Gaps = 58/265 (21%) Query: 116 VSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVL--SSYRAHAAQVTCV 173 V + H+ V +V++ +G +G D ++VW+L + V V Sbjct: 12 VQQTIFRGHEGRVRSVAIDPTGVALATGGDDGTVRVWELLTGRQVWSVKLNG-DEAVNTV 70 Query: 174 AASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVF----- 228 P KD+ L+ + I L P + ++ L + Sbjct: 71 RWRPTKDTFILAAAAGEDIFLMIPTHPSVTPALDQASRDILNAGFGHATNGKQQANLPPG 130 Query: 229 ----------VFGDENGTVSLVDT-------------------------KSTSCVLSSAV 253 E+ V L T +S+ + + + Sbjct: 131 KEPPGKWARPGTRLEDEGVLLRITVRSTIKAISWHRRGDHFATVSPSGQRSSVAIHTLSK 190 Query: 254 HSQCV---------TGLVFSP-HSVPFLASLSEDCSLAVLDSSLSELFRS-QAHRDFVRD 302 H + F P + F+A+ S+ D EL + Q ++ Sbjct: 191 HLTQIPFRKLNGLAQTASFHPLRPLFFVATQ---RSIRCYDLQKLELVKIVQPGAKWISS 247 Query: 303 ATWSPLNHSLLTTVGWDHQVVHHVV 327 P L +D +++ H + Sbjct: 248 FDVHP-GGDNLVVGSYDKRLLWHDL 271 Score = 53.6 bits (127), Expect = 1e-07, Method: Composition-based stats. Identities = 19/119 (15%), Positives = 35/119 (29%), Gaps = 20/119 (16%) Query: 92 RGILVASDSGAVELWELD-ENETLIVSKFCKYEHDDIVSTVSVLSSG-TQAVSGSKDICI 149 ++V S + +LD N +F H + + V G S D + Sbjct: 255 DNLVVGSYDKRLLWHDLDLSNRPYKTMRF----HTEAIRAVRFHKGGLPLFADASDDGSL 310 Query: 150 KVW-------DLAQQV--VLSSYRAHAAQ----VTCVAASPHKDSVFLSCSEDNRILLW 195 +++ L + + H V + P + +S D LW Sbjct: 311 QIFHGKVPNDQLENPTIVPVKMLKGHKVVNKLGVLDIDWHPREP-WCVSAGADGTARLW 368 Score = 50.5 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 45/300 (15%), Positives = 86/300 (28%), Gaps = 68/300 (22%) Query: 94 ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGT---QAVSGSKDICIK 150 + D G V +WEL + K D+ V+TV + A + +DI + Sbjct: 36 LATGGDDGTVRVWELLTGRQVWSVKLNG---DEAVNTVRWRPTKDTFILAAAAGEDIFLM 92 Query: 151 V---------WDLAQQVVLSSYRAHAAQ-------------------------------- 169 + D A + +L++ HA Sbjct: 93 IPTHPSVTPALDQASRDILNAGFGHATNGKQQANLPPGKEPPGKWARPGTRLEDEGVLLR 152 Query: 170 ------VTCVAASPHKDSVFLSCSEDN---RILLWDTRCPKPASQIGCSAPGYLPTSLAW 220 + ++ + F + S + + +QI L + ++ Sbjct: 153 ITVRSTIKAISWH-RRGDHFATVSPSGQRSSVAIHTLSKH--LTQIPFRKLNGLAQTASF 209 Query: 221 HPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSL 280 HP + FV ++ D + V ++ ++ P + S D L Sbjct: 210 HPLRPLFFV--ATQRSIRCYDLQKLELVKIVQPGAKWISSFDVHPGGDNLVV-GSYDKRL 266 Query: 281 AVL---DSSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQV--VHHVVPTEPLPAP 335 + D S + H + +R + L D + H VP + L P Sbjct: 267 -LWHDLDLSNRPYKTMRFHTEAIRAVRFHKGGLPLFADASDDGSLQIFHGKVPNDQLENP 325 Score = 49.0 bits (115), Expect = 3e-06, Method: Composition-based stats. Identities = 17/92 (18%), Positives = 30/92 (32%), Gaps = 10/92 (10%) Query: 250 SSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSEL---FRSQAHRDFVRDATWS 306 H V + P V LA+ +D ++ V + + + V W Sbjct: 16 IFRGHEGRVRSVAIDPTGVA-LATGGDDGTVRVWELLTGRQVWSVKLNG-DEAVNTVRWR 73 Query: 307 PLNHSLL--TTVGWDHQVVHHVVPTEPLPAPG 336 P + + G D + ++PT P P Sbjct: 74 PTKDTFILAAAAGED---IFLMIPTHPSVTPA 102 >5M89-A nrPDB Length = 329 Score = 65.1 bits (157), Expect = 4e-11, Method: Composition-based stats. Identities = 33/220 (15%), Positives = 75/220 (34%), Gaps = 17/220 (7%) Query: 72 FCSAGVQTEAGVADLTWVGERGILVASDSGAVELWEL-DENETLIVSKFCKYEHDDIVST 130 + V W G + +++ + G V++++ E+ T H V+ Sbjct: 84 KVERTLDIGEPVTATEWTGTK-VVIGTAKGWVKVYDAGRESATFQT-------HAGPVTG 135 Query: 131 VSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAA-QVTCVAASPHKDSVFLSCSED 189 ++V G S D +DL ++ R +A +T A P ++F + ++ Sbjct: 136 LAVHPGGRILASVGVDKSFVFYDLETGERVA--RGYADAALTTCAFHPD-GNLFAAGTQT 192 Query: 190 NRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTK-STSCV 248 IL++ T + A P +LA+ G +V++ D + S + Sbjct: 193 GHILVFHTTTLEQAESFPLGTP---IQALAFSENGFWFAATGKGTSSVTIFDLRKSGAAA 249 Query: 249 LSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLS 288 + + V + + ++ + + Sbjct: 250 AVKELQTGEVLSISWDYTGQYLATGGGTGVTVQMYTKATK 289 Score = 56.7 bits (135), Expect = 1e-08, Method: Composition-based stats. Identities = 31/173 (17%), Positives = 52/173 (30%), Gaps = 14/173 (8%) Query: 169 QVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVF 228 VT ++ ++ D ++ ++ K + P T+ W Sbjct: 52 NVTQASSLDLENECAAVGGLDGKLDIYSVVANKVERTLDIGEP---VTATEW---TGTKV 105 Query: 229 VFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLS 288 V G G V + D + + H+ VTGL P LAS+ D S D Sbjct: 106 VIGTAKGWVKVYD--AGRESATFQTHAGPVTGLAVHP-GGRILASVGVDKSFVFYDLETG 162 Query: 289 ELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQVVHHVVPT----EPLPAPGP 337 E + + P + +L ++ T E P P Sbjct: 163 ERVARGYADAALTTCAFHP-DGNLFAAGTQTGHILVFHTTTLEQAESFPLGTP 214 >5WLC-SG nrPDB Length = 573 Score = 65.1 bits (157), Expect = 4e-11, Method: Composition-based stats. Identities = 18/132 (13%), Positives = 40/132 (30%), Gaps = 3/132 (2%) Query: 164 RAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQ 223 H ++ VAASP ++ D ++++W T P I SLA+ Sbjct: 233 EGHYDEILTVAASPD-GKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRRGEVLSLAFRKN 291 Query: 224 QSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVL 283 +++ + + S + H V + + + + D + + Sbjct: 292 SDQLYASCA-DFKIRTYSINQFSQLEILYGHHDIVEDIS-ALAMERCVTVGARDRTAMLW 349 Query: 284 DSSLSELFRSQA 295 + Sbjct: 350 KIPDETRLTFRG 361 Score = 62.4 bits (150), Expect = 2e-10, Method: Composition-based stats. Identities = 30/202 (14%), Positives = 60/202 (29%), Gaps = 15/202 (7%) Query: 123 EHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSY--RAHAAQVTCVAASPHKD 180 H D + TV+ G V+G +D + VW + + +V +A + D Sbjct: 234 GHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRRGEVLSLAFRKNSD 293 Query: 181 SVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLV 240 ++ SC+ D +I + + + ++ G + T L Sbjct: 294 QLYASCA-DFKIRTYSINQFSQLEIL--YGHHDIVEDIS-ALAMERCVTVGARDRTAMLW 349 Query: 241 DTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHRDFV 300 + + + + A ED + D S + LF + D V Sbjct: 350 KIPDETRLTFRGGDEPQKLLRRWMKEN----AKEGEDGEVKYPDESEAPLFFCEGSIDVV 405 Query: 301 RDATWSPLNHSLLTTVGWDHQV 322 + T + + Sbjct: 406 SMV-----DDFHFITGSDNGNI 422 Score = 52.8 bits (125), Expect = 2e-07, Method: Composition-based stats. Identities = 34/254 (13%), Positives = 70/254 (27%), Gaps = 30/254 (11%) Query: 72 FCSAGVQTEAGVADLTWVGERGILVASD-SGAVELWELDENETLIVSKFCKYEHDDIVST 130 V L + L AS + + +++ L + Y H DIV Sbjct: 272 KVIPTKDRRGEVLSLAFRKNSDQLYASCADFKIRTYSINQFSQLEI----LYGHHDIVED 327 Query: 131 VSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCV-AASPHKDSVFLSCSED 189 +S L+ G++D +W + + L ++R + ED Sbjct: 328 ISALAMERCVTVGARDRTAMLWKIPDETRL-TFRGGDEPQKLLRRWMKENAKE----GED 382 Query: 190 NRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVL 249 + D G + F+ G +NG + L + Sbjct: 383 GEVKYPDESEAPLFFCEGSIDVVSMV--------DDFHFITGSDNGNICLWSLAKKKPIF 434 Query: 250 SSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHRDFVRDATWSPLN 309 + + + F+ S D L +L + ++ P + Sbjct: 435 TERIAHGILPEPSFND------ISGETDEELRKRQLQGKKLLQPF----WITSLYAIPYS 484 Query: 310 HSLLTTVGWDHQVV 323 ++ + W + Sbjct: 485 -NVFISGSWSGSLK 497 Score = 50.5 bits (119), Expect = 9e-07, Method: Composition-based stats. Identities = 40/243 (16%), Positives = 78/243 (32%), Gaps = 57/243 (23%) Query: 83 VADL-TWVGERGILVASDSGAVELWELDENETL--------------IVSKFCKYEHDDI 127 V D+ ER + V + LW++ + L + + K D Sbjct: 325 VEDISALAMERCVTVGARDRTAMLWKIPDETRLTFRGGDEPQKLLRRWMKENAKEGEDGE 384 Query: 128 VS----------------TVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYR-AHAAQV 170 V V + ++GS + I +W LA++ + + R AH Sbjct: 385 VKYPDESEAPLFFCEGSIDVVSMVDDFHFITGSDNGNICLWSLAKKKPIFTERIAH---- 440 Query: 171 TCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVF 230 + P + + S D + + K + TSL + S VF+ Sbjct: 441 -GILPEPSFNDI--SGETDEELRKRQLQGKKLLQ-------PFWITSL-YAIPYSNVFIS 489 Query: 231 GDENGTVSLV----DTKSTSCVLSSAVHSQCVTGLVFSPHSV------PFLASLSEDCSL 280 G +G++ + + +S + + VT + LAS++++ L Sbjct: 490 GSWSGSLKVWKISDNLRSFELLGELSGAKGVVTKIQVVESGKHGKEKFRILASIAKEHRL 549 Query: 281 AVL 283 Sbjct: 550 GRW 552 Score = 47.0 bits (110), Expect = 1e-05, Method: Composition-based stats. Identities = 22/154 (14%), Positives = 49/154 (31%), Gaps = 38/154 (24%) Query: 80 EAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFC-----------KYEHDD-- 126 E + ++ V + + SD+G + LW L + + + + D Sbjct: 399 EGSIDVVSMVDDFHFITGSDNGNICLWSLAKKKPIFTERIAHGILPEPSFNDISGETDEE 458 Query: 127 ---------------IVSTVSVLSSGTQAVSGSKDICIKVW----DLAQQVVLSSYRAHA 167 ++++ + +SGS +KVW +L +L Sbjct: 459 LRKRQLQGKKLLQPFWITSLYAIPYSNVFISGSWSGSLKVWKISDNLRSFELLGELSGAK 518 Query: 168 AQVTCVAASPHKD------SVFLSCSEDNRILLW 195 VT + + S ++++R+ W Sbjct: 519 GVVTKIQVVESGKHGKEKFRILASIAKEHRLGRW 552 Score = 35.5 bits (80), Expect = 0.036, Method: Composition-based stats. Identities = 21/158 (13%), Positives = 48/158 (30%), Gaps = 18/158 (11%) Query: 167 AAQVTCVA-ASPHKDSVFL---SCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHP 222 +TC++ P + S + N+ L+ K Y T + P Sbjct: 154 ENNLTCISCFQPVLNKYTFEESSNGDKNKGRLFAYTVSKDLQL-----TKYDITDFSKRP 208 Query: 223 QQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAV 282 ++ + G + T ++ H + + SP ++ + D L V Sbjct: 209 KKLKYAKGGA-----KYIPTSKHEYENTTEGHYDEILTVAASPDG-KYVVTGGRDRKLIV 262 Query: 283 LDSSL---SELFRSQAHRDFVRDATWSPLNHSLLTTVG 317 + ++ ++ R V + + L + Sbjct: 263 WSTESLSPVKVIPTKDRRGEVLSLAFRKNSDQLYASCA 300 >4J0X-A nrPDB Length = 451 Score = 65.1 bits (157), Expect = 4e-11, Method: Composition-based stats. Identities = 18/132 (13%), Positives = 40/132 (30%), Gaps = 3/132 (2%) Query: 164 RAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQ 223 H ++ VAASP ++ D ++++W T P I SLA+ Sbjct: 111 EGHYDEILTVAASPD-GKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRRGEVLSLAFRKN 169 Query: 224 QSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVL 283 +++ + + S + H V + + + + D + + Sbjct: 170 SDQLYASCA-DFKIRTYSINQFSQLEILYGHHDIVEDIS-ALAMERCVTVGARDRTAMLW 227 Query: 284 DSSLSELFRSQA 295 + Sbjct: 228 KIPDETRLTFRG 239 Score = 62.4 bits (150), Expect = 2e-10, Method: Composition-based stats. Identities = 30/202 (14%), Positives = 60/202 (29%), Gaps = 15/202 (7%) Query: 123 EHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSY--RAHAAQVTCVAASPHKD 180 H D + TV+ G V+G +D + VW + + +V +A + D Sbjct: 112 GHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRRGEVLSLAFRKNSD 171 Query: 181 SVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLV 240 ++ SC+ D +I + + + ++ G + T L Sbjct: 172 QLYASCA-DFKIRTYSINQFSQLEIL--YGHHDIVEDIS-ALAMERCVTVGARDRTAMLW 227 Query: 241 DTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHRDFV 300 + + + + A ED + D S + LF + D V Sbjct: 228 KIPDETRLTFRGGDEPQKLLRRWMKEN----AKEGEDGEVKYPDESEAPLFFCEGSIDVV 283 Query: 301 RDATWSPLNHSLLTTVGWDHQV 322 + T + + Sbjct: 284 SMV-----DDFHFITGSDNGNI 300 Score = 52.8 bits (125), Expect = 2e-07, Method: Composition-based stats. Identities = 34/254 (13%), Positives = 70/254 (27%), Gaps = 30/254 (11%) Query: 72 FCSAGVQTEAGVADLTWVGERGILVASD-SGAVELWELDENETLIVSKFCKYEHDDIVST 130 V L + L AS + + +++ L + Y H DIV Sbjct: 150 KVIPTKDRRGEVLSLAFRKNSDQLYASCADFKIRTYSINQFSQLEI----LYGHHDIVED 205 Query: 131 VSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCV-AASPHKDSVFLSCSED 189 +S L+ G++D +W + + L ++R + ED Sbjct: 206 ISALAMERCVTVGARDRTAMLWKIPDETRL-TFRGGDEPQKLLRRWMKENAKE----GED 260 Query: 190 NRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVL 249 + D G + F+ G +NG + L + Sbjct: 261 GEVKYPDESEAPLFFCEGSIDVVSMV--------DDFHFITGSDNGNICLWSLAKKKPIF 312 Query: 250 SSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHRDFVRDATWSPLN 309 + + + F+ S D L +L + ++ P + Sbjct: 313 TERIAHGILPEPSFND------ISGETDEELRKRQLQGKKLLQPF----WITSLYAIPYS 362 Query: 310 HSLLTTVGWDHQVV 323 ++ + W + Sbjct: 363 -NVFISGSWSGSLK 375 Score = 50.5 bits (119), Expect = 9e-07, Method: Composition-based stats. Identities = 40/243 (16%), Positives = 78/243 (32%), Gaps = 57/243 (23%) Query: 83 VADL-TWVGERGILVASDSGAVELWELDENETL--------------IVSKFCKYEHDDI 127 V D+ ER + V + LW++ + L + + K D Sbjct: 203 VEDISALAMERCVTVGARDRTAMLWKIPDETRLTFRGGDEPQKLLRRWMKENAKEGEDGE 262 Query: 128 VS----------------TVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYR-AHAAQV 170 V V + ++GS + I +W LA++ + + R AH Sbjct: 263 VKYPDESEAPLFFCEGSIDVVSMVDDFHFITGSDNGNICLWSLAKKKPIFTERIAH---- 318 Query: 171 TCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVF 230 + P + + S D + + K + TSL + S VF+ Sbjct: 319 -GILPEPSFNDI--SGETDEELRKRQLQGKKLLQ-------PFWITSL-YAIPYSNVFIS 367 Query: 231 GDENGTVSLV----DTKSTSCVLSSAVHSQCVTGLVFSPHSV------PFLASLSEDCSL 280 G +G++ + + +S + + VT + LAS++++ L Sbjct: 368 GSWSGSLKVWKISDNLRSFELLGELSGAKGVVTKIQVVESGKHGKEKFRILASIAKEHRL 427 Query: 281 AVL 283 Sbjct: 428 GRW 430 Score = 47.0 bits (110), Expect = 1e-05, Method: Composition-based stats. Identities = 22/154 (14%), Positives = 49/154 (31%), Gaps = 38/154 (24%) Query: 80 EAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFC-----------KYEHDD-- 126 E + ++ V + + SD+G + LW L + + + + D Sbjct: 277 EGSIDVVSMVDDFHFITGSDNGNICLWSLAKKKPIFTERIAHGILPEPSFNDISGETDEE 336 Query: 127 ---------------IVSTVSVLSSGTQAVSGSKDICIKVW----DLAQQVVLSSYRAHA 167 ++++ + +SGS +KVW +L +L Sbjct: 337 LRKRQLQGKKLLQPFWITSLYAIPYSNVFISGSWSGSLKVWKISDNLRSFELLGELSGAK 396 Query: 168 AQVTCVAASPHKD------SVFLSCSEDNRILLW 195 VT + + S ++++R+ W Sbjct: 397 GVVTKIQVVESGKHGKEKFRILASIAKEHRLGRW 430 Score = 35.5 bits (80), Expect = 0.036, Method: Composition-based stats. Identities = 21/158 (13%), Positives = 48/158 (30%), Gaps = 18/158 (11%) Query: 167 AAQVTCVA-ASPHKDSVFL---SCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHP 222 +TC++ P + S + N+ L+ K Y T + P Sbjct: 32 ENNLTCISCFQPVLNKYTFEESSNGDKNKGRLFAYTVSKDLQL-----TKYDITDFSKRP 86 Query: 223 QQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAV 282 ++ + G + T ++ H + + SP ++ + D L V Sbjct: 87 KKLKYAKGGA-----KYIPTSKHEYENTTEGHYDEILTVAASPDG-KYVVTGGRDRKLIV 140 Query: 283 LDSSL---SELFRSQAHRDFVRDATWSPLNHSLLTTVG 317 + ++ ++ R V + + L + Sbjct: 141 WSTESLSPVKVIPTKDRRGEVLSLAFRKNSDQLYASCA 178 >5AJA-A nrPDB Length = 361 Score = 59.4 bits (142), Expect = 2e-09, Method: Composition-based stats. Identities = 27/217 (12%), Positives = 62/217 (28%), Gaps = 55/217 (25%) Query: 129 STVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSC-- 186 + + + + G+ +K++++ +SY H + +T + S + S Sbjct: 41 TCCAFSARERFLMLGTCTGQLKLYNVFSGQEEASYNCHNSAITHLEPSRDGSLLLTSATW 100 Query: 187 -------------------------------SEDNRIL-------LWDTRCPKPASQIGC 208 S+D I ++D + + Sbjct: 101 SQPLSALWGMKSVFDMKHSFTEDHYVEFSKHSQDRVIGTKGDIAHIYDIQTGNKLLTLFN 160 Query: 209 S--APGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPH 266 A Y ++P V +G L D +S + + ++G+ F P+ Sbjct: 161 PDLANNYKRNCATFNPTDDLVL----NDGV--LWDVRSAQAIHKFDKFNMNISGV-FHPN 213 Query: 267 SVPFLASLSEDCSLAVLDSSLSELFRSQAHRDFVRDA 303 + + + + D L + D R Sbjct: 214 GLEVIINT------EIWDLRTFHLLHTVPALDQCRVV 244 Score = 47.4 bits (111), Expect = 9e-06, Method: Composition-based stats. Identities = 21/201 (10%), Positives = 61/201 (30%), Gaps = 28/201 (13%) Query: 26 CMERQLEAARYRSDGALLLGASSLSGRCWAGSLWLFKDPCAAPNEGFCSAGVQTEAGVAD 85 C + DG+LLL +++ S +LW K + Sbjct: 77 CHNSAITHLEPSRDGSLLLTSATWSQPL--SALWGMKS---------VFDMKHSFTEDHY 125 Query: 86 LTWV-GERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGS 144 + + + ++ + ++++ L+ ++ + + + + Sbjct: 126 VEFSKHSQDRVIGTKGDIAHIYDIQTGNKLLTLFNPDLANNYKRNCATFNPTDDLVL--- 182 Query: 145 KDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPAS 204 D +WD+ + + ++ V P+ V ++ +WD R Sbjct: 183 NDG--VLWDVRSAQAIHKFDKFNMNISGV-FHPNGLEVIINT------EIWDLRT----F 229 Query: 205 QIGCSAPGYLPTSLAWHPQQS 225 + + P + ++ + Sbjct: 230 HLLHTVPALDQCRVVFNHTGT 250 >5WLC-LW nrPDB Length = 554 Score = 59.0 bits (141), Expect = 3e-09, Method: Composition-based stats. Identities = 32/215 (14%), Positives = 68/215 (31%), Gaps = 16/215 (7%) Query: 94 ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWD 153 +L+ G V + + + + H + + L + K ++D Sbjct: 125 LLITGRKGHVASMDWRKGQLRAELFLNETCH-----SATYLQNEQYFAVAQKKYTF-IYD 178 Query: 154 LAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSA-PG 212 + L + H + P+ + ++ E + D + S++ A P Sbjct: 179 -HEGTELHRLKQHIEA-RHLDFLPYH-YLLVTAGETGWLKYHDVSTGQLVSELRTKAGPT 235 Query: 213 YLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLA 272 W+ V G NGTVSL ++ V + S ++A Sbjct: 236 MAMAQNPWN----AVMHLGHSNGTVSLWSPSMPEPLVKLLSARGPVNSIAI-DRSGYYMA 290 Query: 273 SLSEDCSLAVLDSS-LSELFRSQAHRDFVRDATWS 306 + D S+ + D +L ++ + + S Sbjct: 291 TTGADRSMKIWDIRNFKQLHSVESLPTPGTNVSIS 325 Score = 49.4 bits (116), Expect = 3e-06, Method: Composition-based stats. Identities = 14/115 (12%), Positives = 37/115 (32%), Gaps = 5/115 (4%) Query: 93 GILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVW 152 ++ A ++G ++ ++ + +VS+ ++ G + + +W Sbjct: 204 LLVTAGETGWLKYHDVSTGQ--LVSELRTKA--GPTMAMAQNPWNAVMHLGHSNGTVSLW 259 Query: 153 DLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIG 207 + L + V +A + D + +WD R K + Sbjct: 260 SPSMPEPLVKLLSARGPVNSIAID-RSGYYMATTGADRSMKIWDIRNFKQLHSVE 313 Score = 44.3 bits (103), Expect = 7e-05, Method: Composition-based stats. Identities = 22/99 (22%), Positives = 38/99 (38%), Gaps = 7/99 (7%) Query: 97 ASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQ 156 +G V LW E L+ + V+++++ SG + D +K+WD+ Sbjct: 250 GHSNGTVSLWSPSMPEPLVKLLSAR----GPVNSIAIDRSGYYMATTGADRSMKIWDIRN 305 Query: 157 QVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLW 195 L S + T V+ S L+ S + LW Sbjct: 306 FKQLHSVESLPTPGTNVSISDTG---LLALSRGPHVTLW 341 >6CHG-D nrPDB Length = 439 Score = 57.8 bits (138), Expect = 7e-09, Method: Composition-based stats. Identities = 37/243 (15%), Positives = 81/243 (33%), Gaps = 27/243 (11%) Query: 60 LFKDPCAAPNE--GFCSAGVQTEAGVADLTWVGERGIL-VASDSGAVELWELDENETLIV 116 L +DP E + ++ + + L V +GA+ ++++D + + + Sbjct: 5 LLQDPFGVLKEYPEKLTHTLEVPVAAVCVKFSPRGDYLAVGCSNGAIIIYDMDSLKPIAM 64 Query: 117 SKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQV-VLSSYRAHAAQVTC--- 172 H V +V + G S +D K+WD+ Q Y+ + Sbjct: 65 LGTHSGAHTRSVQSVCWSNDGRYLWSSGRDWYAKLWDMTQPTKCFQQYKF-DGPLWSCHV 123 Query: 173 VAASPHKDSVFLSCSEDNRILLWDTRCPK------PASQIGCSAPGYLPTSLAW-HPQQS 225 V + ++ E+ + + P + G+ T +A HP Sbjct: 124 VRWNVC----IVTVVEEPTAYVLTLTDRQNAFHCFPLLEQDQDISGHGYTLVACPHPTIE 179 Query: 226 EVFVFGDENGTVSLV--DTKST-----SCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDC 278 + + G G ++ D +S C + + + ++ SP + S D Sbjct: 180 SIIITGTSKGWINAFQLDLESGFEDKIRCCYEEKIANANIKQIIISPSGTRIAINGS-DR 238 Query: 279 SLA 281 ++ Sbjct: 239 TIR 241 Score = 51.3 bits (121), Expect = 7e-07, Method: Composition-based stats. Identities = 25/168 (14%), Positives = 52/168 (30%), Gaps = 25/168 (14%) Query: 140 AVSGSKDICIKVW--DLAQQ-----VVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRI 192 ++G+ I + DL + A + + SP + ++ S D I Sbjct: 182 IITGTSKGWINAFQLDLESGFEDKIRCCYEEKIANANIKQIIISPSGTRIAINGS-DRTI 240 Query: 193 LLWDTRCPKPASQIGCSAPGYL---------PTSLAWHP-----QQSEVFVF---GDENG 235 + S+ G S + L W+ E V G Sbjct: 241 RQYQLIVEDNESEGGSSHSVSIELEHKYQDIINRLQWNTIFFSNHSGEYLVASAHGSSAH 300 Query: 236 TVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVL 283 + L +T S S V + + + ++ +S+ ++ E + + Sbjct: 301 DLYLWETSSGSLVRVLEGADEELLDIDWNFYSMRIASNGFESGWVYMW 348 Score = 34.7 bits (78), Expect = 0.060, Method: Composition-based stats. Identities = 24/180 (13%), Positives = 61/180 (33%), Gaps = 18/180 (10%) Query: 73 CSAGVQTEAGVADLTWVGE-RGILVASDSGAVELWEL--DENETLIVSKFC---KYEHD- 125 C A + + I + + ++L ++NE+ S + EH Sbjct: 209 CYEEKIANANIKQIIISPSGTRIAINGSDRTIRQYQLIVEDNESEGGSSHSVSIELEHKY 268 Query: 126 -DIVSTVSVL------SSGTQAVS---GSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAA 175 DI++ + SG V+ GS + +W+ + ++ ++ + Sbjct: 269 QDIINRLQWNTIFFSNHSGEYLVASAHGSSAHDLYLWETSSGSLVRVLEGADEELLDIDW 328 Query: 176 SPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENG 235 + + + + E + +W P S + + + +++E + D+N Sbjct: 329 NFYSMRIASNGFESGWVYMWSIVIPPKWSALAPDFEEVEEN-IDYQEKENEFDIMDDDNN 387 >3DW8-B nrPDB Length = 447 Score = 57.4 bits (137), Expect = 8e-09, Method: Composition-based stats. Identities = 43/259 (16%), Positives = 93/259 (35%), Gaps = 55/259 (21%) Query: 75 AGVQTEAGVADLTWVGERG---ILVASDSGAVELWELDENET-----LIVSKFCKYEHDD 126 ++ E + + W+ ++ L++++ ++LW++ E + + + +Y Sbjct: 88 KSLEIEEKINKIRWLPQKNAAQFLLSTNDKTIKLWKISERDKRPEGYNLKEEDGRYRDPT 147 Query: 127 IVST--VSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSY-RAHAAQVTCVAASPHKDSVF 183 V+T V V V S + AH + ++ + ++ Sbjct: 148 TVTTLRVPVFRPMDLMVEAS--------------PRRIFANAHTYHINSISINSDYETYL 193 Query: 184 LSCSEDNRILLWDTRCPKPASQIGCSAP------GYLPTSLAWHPQQSEVFVFGDENGTV 237 ++D RI LW + I P + T+ +HP FV+ GT+ Sbjct: 194 --SADDLRINLWHLEITDRSFNIVDIKPANMEELTEVITAAEFHPNSCNTFVYSSSKGTI 251 Query: 238 SLVDTKSTS-CVLSSAVHS---------------QCVTGLVFSPHSVPFLASLSEDC-SL 280 L D ++++ C S + ++ + FS HS ++ + D S+ Sbjct: 252 RLCDMRASALCDRHSKLFEEPEDPSNRSFFSEIISSISDVKFS-HSGRYMMT--RDYLSV 308 Query: 281 AVLDSSL--SELFRSQAHR 297 V D ++ + Q H Sbjct: 309 KVWDLNMENRPVETYQVHE 327 >6CVZ-A nrPDB Length = 351 Score = 57.4 bits (137), Expect = 8e-09, Method: Composition-based stats. Identities = 20/81 (24%), Positives = 32/81 (39%), Gaps = 3/81 (3%) Query: 166 HAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQS 225 H Q+ +A S + + LS S DN I L P + S W ++ Sbjct: 73 HGKQIRGLAFSSYLRGLLLSASLDNTIKLTSLETNTVVQTYNAGRPVW---SCCWCLDEA 129 Query: 226 EVFVFGDENGTVSLVDTKSTS 246 G NG++ + D ++TS Sbjct: 130 NYIYAGLANGSILVYDVRNTS 150 Score = 47.0 bits (110), Expect = 1e-05, Method: Composition-based stats. Identities = 19/108 (17%), Positives = 38/108 (35%), Gaps = 3/108 (2%) Query: 123 EHDDIVSTVSVLSSGT-QAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDS 181 H + ++ S +S S D IK+ L V+ +Y A V + + Sbjct: 72 MHGKQIRGLAFSSYLRGLLLSASLDNTIKLTSLETNTVVQTYNA-GRPVWSCCWCLDEAN 130 Query: 182 VFLSCSEDNRILLWDTRCPKP-ASQIGCSAPGYLPTSLAWHPQQSEVF 228 + + IL++D R ++ SL++ P+ + Sbjct: 131 YIYAGLANGSILVYDVRNTSSHVQELVAQKARCPLVSLSYMPRAASAA 178 Score = 37.8 bits (86), Expect = 0.007, Method: Composition-based stats. Identities = 19/107 (17%), Positives = 40/107 (37%), Gaps = 5/107 (4%) Query: 221 HPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSL 280 PQ S + FG V ++ T + +H + + GL FS + L S S D ++ Sbjct: 45 SPQASFLPGFG-----VKMLSTANMKSSQYIPMHGKQIRGLAFSSYLRGLLLSASLDNTI 99 Query: 281 AVLDSSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQVVHHVV 327 + + + ++ V W + + + ++ + V Sbjct: 100 KLTSLETNTVVQTYNAGRPVWSCCWCLDEANYIYAGLANGSILVYDV 146 >5MC6-j nrPDB Length = 397 Score = 54.4 bits (129), Expect = 6e-08, Method: Composition-based stats. Identities = 23/154 (14%), Positives = 54/154 (35%), Gaps = 23/154 (14%) Query: 125 DDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRA-HA-----AQVTCVAASPH 178 ++V + G +G + +++ +L+ L ++ + H+ + V SP Sbjct: 186 SQFATSVDISERG-LIATGFNNGTVQISELSTLRPLYNFESQHSMINNSNSIRSVKFSPQ 244 Query: 179 KDSVFL---SCSEDNRILLWDTR-----------CPKPASQIGCSAPGYLPTSLAWHPQQ 224 + + S S I L++T + +G A SL+++ Sbjct: 245 GSLLAIAHDSNSFGC-ITLYETEFGERIGSLSVPTHSSQASLGEFAHSSWVMSLSFN-DS 302 Query: 225 SEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCV 258 E +G + D K+ + + +H + Sbjct: 303 GETLCSAGWDGKLRFWDVKTKERITTLNMHCDDI 336 Score = 54.4 bits (129), Expect = 8e-08, Method: Composition-based stats. Identities = 19/165 (11%), Positives = 48/165 (29%), Gaps = 19/165 (11%) Query: 70 EGFCSAGVQTEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKF--CKYEHDDI 127 +G + + + I ++G V++ EL L + + + Sbjct: 176 QGTVESPMTPSQFATSVDISERGLIATGFNNGTVQISELSTLRPLYNFESQHSMINNSNS 235 Query: 128 VSTVSVLSSGTQAVSGSKD---ICIKVWDLAQQVVLSSYR-------------AHAAQVT 171 + +V G+ CI +++ + S AH++ V Sbjct: 236 IRSVKFSPQGSLLAIAHDSNSFGCITLYETEFGERIGSLSVPTHSSQASLGEFAHSSWVM 295 Query: 172 CVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPT 216 ++ + S D ++ WD + + + + Sbjct: 296 SLSFN-DSGETLCSAGWDGKLRFWDVKTKERITTLNMHCDDIEIE 339 Score = 39.3 bits (90), Expect = 0.002, Method: Composition-based stats. Identities = 33/246 (13%), Positives = 68/246 (27%), Gaps = 60/246 (24%) Query: 123 EHDDIVSTVSVLSSGTQAVSGSKDICIKVWD------------LAQQVVLSSYRAHAAQV 170 HD + +V + + VS S D +KVWD V S H + Sbjct: 14 AHDADIFSV--SACNSFTVSCSGDGYLKVWDNKLLDNENPKDKSYSHFVHKSGLHHVDVL 71 Query: 171 TCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQ--------IGCSAPGYLPTSLAWHP 222 + + + + S +L + + + + +L W Sbjct: 72 QAIERDAFELCLVATTSFSGDLLFYRITREDETKKVIFEKLDLLDSDMKKHSFWALKWGA 131 Query: 223 QQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTG--LVFSPH-------------- 266 + + D K T+ + + L +SP Sbjct: 132 SNDRLLS-----HRLVATDVKGTTYIWKFHPFADESNSLTLNWSPTLELQGTVESPMTPS 186 Query: 267 ---------SVPFLASLSEDCSLAVLDSSL-SELFRSQAH------RDFVRDATWSPLNH 310 +A+ + ++ + + S L+ ++ + +R +SP Sbjct: 187 QFATSVDISERGLIATGFNNGTVQISELSTLRPLYNFESQHSMINNSNSIRSVKFSPQ-G 245 Query: 311 SLLTTV 316 SLL Sbjct: 246 SLLAIA 251 >3DWL-C nrPDB Length = 377 Score = 53.2 bits (126), Expect = 1e-07, Method: Composition-based stats. Identities = 42/215 (19%), Positives = 72/215 (33%), Gaps = 35/215 (16%) Query: 94 ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWD 153 + + + VEL+E D N F HD IV+ V + V+ S+D V++ Sbjct: 26 FVTTTATNQVELYEQDGNGWKHARTFSD--HDKIVTCVDWAPKSNRIVTCSQDRNAYVYE 83 Query: 154 ------LAQQVVLSSYRAHAAQVTCVAASPHKDSVFL-SCSEDNRILLWDTRCPKPASQI 206 Q +VL T V SP++D + S + + ++ S+ Sbjct: 84 KRPDGTWKQTLVLLRL---NRAATFVRWSPNEDKFAVGSGARVISVCYFEQENDWWVSKH 140 Query: 207 GCSAPGYLPTSLAWHPQQSEVFVFGDENGTVS----------------LVDTK---STSC 247 SL WHP + + G + + ++ +T C Sbjct: 141 LKRPLRSTILSLDWHPN-NVLLAAGCADRKAYVLSAYVRDVDAKPEASVWGSRLPFNTVC 199 Query: 248 VLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAV 282 + V + FSP LA D S+ + Sbjct: 200 AEYPSG--GWVHAVGFSPSGNA-LAYAGHDSSVTI 231 Score = 30.9 bits (68), Expect = 0.75, Method: Composition-based stats. Identities = 8/67 (11%), Positives = 19/67 (28%), Gaps = 5/67 (7%) Query: 262 VFSPHSVPFLASLSEDCSLAVLDSS---LSELFRSQAHRDFVRDATWSPLNHSLLTTVGW 318 F+ F+ + + + + + H V W+P + + T Sbjct: 18 AFNSQRTEFVTTTAT-NQVELYEQDGNGWKHARTFSDHDKIVTCVDWAP-KSNRIVTCSQ 75 Query: 319 DHQVVHH 325 D + Sbjct: 76 DRNAYVY 82 Score = 30.9 bits (68), Expect = 0.84, Method: Composition-based stats. Identities = 34/200 (17%), Positives = 59/200 (29%), Gaps = 24/200 (12%) Query: 12 PAAREWN-LPPNAPACMERQLEAARYRSDGALLLGAS-SLSGRCWAGSLWLFKDPCAAPN 69 P A W P C E + + G G + + +G + ++ P P Sbjct: 184 PEASVWGSRLPFNTVCAEYPSGGWVH-AVGFSPSGNALAYAGHDSSVTIAYPSAPEQPPR 242 Query: 70 EGFCSAGVQTEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVS 129 Q L W E I+ A + + L L NE+ D S Sbjct: 243 ALITVKLSQLPLR--SLLWANESAIVAAGYNYSPIL--LQGNESGWAHTRDL---DAGTS 295 Query: 130 TVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCV--------------AA 175 S +G ++ + L + + ++ + A Sbjct: 296 KTSFTHTGNTGEGREEEGPVSFTALRSTFRNMDLKGSSQSISSLPTVHQNMIATLRPYAG 355 Query: 176 SPHKDSVFLSCSEDNRILLW 195 +P + F S D R++LW Sbjct: 356 TPGNITAFTSSGTDGRVVLW 375 >5LTD-A nrPDB Length = 525 Score = 52.0 bits (123), Expect = 4e-07, Method: Composition-based stats. Identities = 23/139 (16%), Positives = 48/139 (34%), Gaps = 18/139 (12%) Query: 99 DSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDIC-IKVWDLAQQ 157 +G V +++ + V + H ++ +++ G + S I+V+ +A Sbjct: 200 RNGDVIIFDAKTLQPTSVIE----AHRTSLAAIALSKDGLLLATASDKGTIIRVFSVATG 255 Query: 158 VVLSSYRAHAAQ--VTCVAASPHKDSVFLSCSEDNRILLWDT----------RCPKPASQ 205 + L +R + +A SP V S + + + ++ K A Sbjct: 256 IKLYQFRRGTYPTKIYSLAFSPDNRFVIASSATE-TVHIFRLGEEEAANTIKSANKKARL 314 Query: 206 IGCSAPGYLPTSLAWHPQQ 224 P L TS +P Sbjct: 315 TKAQVPNPLETSPDIYPHN 333 Score = 39.3 bits (90), Expect = 0.003, Method: Composition-based stats. Identities = 16/96 (16%), Positives = 29/96 (30%), Gaps = 3/96 (3%) Query: 146 DICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNR-ILLWDTRCPKPAS 204 + + ++D S AH + +A S + + S+ I ++ Sbjct: 201 NGDVIIFDAKTLQPTSVIEAHRTSLAAIALSKD-GLLLATASDKGTIIRVFSVATGIKLY 259 Query: 205 QIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLV 240 Q SLA+ P V TV + Sbjct: 260 QFRRGTYPTKIYSLAFSPDNRFVIAS-SATETVHIF 294 Score = 37.0 bits (84), Expect = 0.012, Method: Composition-based stats. Identities = 21/161 (13%), Positives = 54/161 (33%), Gaps = 29/161 (18%) Query: 148 CIKVWDLAQQVVLSSYRAHAAQVTCVAASPH-KDSVFLSCS------------------- 187 I ++D+ +L + + +A SP +++ S Sbjct: 138 TIYIYDINNMRLLHTIETPSNPNGLIALSPSSENNYLAYPSPQKLAPNPQTEVTLHSNPQ 197 Query: 188 --EDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTV-SLVDTKS 244 + ++++D + +P S I +L+ + + + GT+ + + Sbjct: 198 TVRNGDVIIFDAKTLQPTSVIEAHRTSLAAIALS---KDGLLLATASDKGTIIRVFSVAT 254 Query: 245 TSCVLSSAV--HSQCVTGLVFSPHSVPFLASLSEDCSLAVL 283 + + + L FSP + +AS S ++ + Sbjct: 255 GIKLYQFRRGTYPTKIYSLAFSPDNRFVIAS-SATETVHIF 294 >5AMS-A nrPDB Length = 431 Score = 51.3 bits (121), Expect = 6e-07, Method: Composition-based stats. Identities = 41/296 (13%), Positives = 77/296 (26%), Gaps = 77/296 (26%) Query: 93 GILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKV- 151 + LW Y V + S S G V+ + V Sbjct: 79 LVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGES--VISCSFTSEGGFLVTADMSGKVLVH 136 Query: 152 --------WDLAQQ----VVLSSYRAH------------AAQVTCVAASPHKDSV----- 182 W LA Q + + H V C + S+ Sbjct: 137 MGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCYQINEQDGSLEQLMS 196 Query: 183 ------------------------FLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPT-- 216 ++CS D+ I+ W+ + +I + L Sbjct: 197 GFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNCFTGQQLFKITQAEIKGLEAPW 256 Query: 217 -SLAWHPQ-----QSEVFVFGDENGTVSLVDTKSTSCVLSSAVH----------SQCVTG 260 SL+ P+ S V G NG +++++ + +L + + Sbjct: 257 ISLSLAPETLTKGNSGVVACGSNNGLLAVINCNNGGAILHLSTVIELKPEQDELDASIES 316 Query: 261 LVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHRDFVRDATWSPLNHSLLTTV 316 + +S +A + + D+S + D V + N L + Sbjct: 317 ISWS-SKFSLMAIGLVCGEILLYDTSAWRVRHKFVLEDSVTKLMFD--NDDLFASC 369 Score = 50.9 bits (120), Expect = 8e-07, Method: Composition-based stats. Identities = 26/174 (14%), Positives = 53/174 (30%), Gaps = 16/174 (9%) Query: 124 HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVL--SSYRAHAAQVTCVAASPHKDS 181 H D V + + +G D +W Q + + V + + Sbjct: 64 HTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSF-TSEGG 122 Query: 182 VFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAW---HPQQSEVFVFGDENGTVS 238 ++ ++L+ + ++ + W HP + F FG +G+V Sbjct: 123 FLVTADMSGKVLVHMGQKGGAQWKLASQMQE--VEEIVWLKTHPTIARTFAFGATDGSVW 180 Query: 239 LVDTK----STSCVLSSAVHSQCVTGLVFSPHSVP----FLASLSEDCSLAVLD 284 S ++S VH Q + F L + S D ++ + Sbjct: 181 CYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWN 234 >4AV8-A nrPDB Length = 339 Score = 49.4 bits (116), Expect = 2e-06, Method: Composition-based stats. Identities = 28/152 (18%), Positives = 57/152 (37%), Gaps = 19/152 (12%) Query: 164 RAHAAQVTCVAASPHKDSVFLSCSEDNR-ILLWDTRCPKPASQIGCSAPGYLPTSLAWHP 222 +AHA V V + K + +CS+D I ++ T + + W P Sbjct: 176 KAHANPVKMVRLN-RKGDMVATCSQDGTLIRVFQTDNGVLVREFRRGLDRTSIIDMRWSP 234 Query: 223 QQSEVFVFGDENGTVSLV----DTKSTSCVLSSAVHSQCVTGLVFSPHSVPF-LASLSED 277 S++ V + T+ + D ++ VL ++ + +S + ++ S D Sbjct: 235 DGSKLAVV-SDKWTLHVFEVFNDAENKRHVLKDWINIKYFQS-EWSICNFKLKVSKGSND 292 Query: 278 CSLA---------VL-DSSLSELFRSQAHRDF 299 C +A V + L++ F+ + D Sbjct: 293 CKIAWISDTGLVIVWPNRRLADTFKLNYNDDE 324 Score = 45.5 bits (106), Expect = 4e-05, Method: Composition-based stats. Identities = 18/101 (17%), Positives = 38/101 (37%), Gaps = 5/101 (4%) Query: 101 GAVELWELDENETLIVSK-FCKYEHDDIVSTVSVLSSGTQAVSGSKDIC-IKVWDLAQQV 158 G + + L + +V K H + V V + G + S+D I+V+ V Sbjct: 154 GQIHVTRLQTDAEQVVGKGVLVKAHANPVKMVRLNRKGDMVATCSQDGTLIRVFQTDNGV 213 Query: 159 VLSSYRAHAA--QVTCVAASPHKDSVFLSCSEDNRILLWDT 197 ++ +R + + SP S S+ + +++ Sbjct: 214 LVREFRRGLDRTSIIDMRWSPD-GSKLAVVSDKWTLHVFEV 253 >6IYY-A nrPDB Length = 317 Score = 49.0 bits (115), Expect = 3e-06, Method: Composition-based stats. Identities = 36/228 (15%), Positives = 68/228 (29%), Gaps = 46/228 (20%) Query: 95 LVASDSGAVELWELDENET---------------------------LIVSKFCKYEHDDI 127 LV V +W+ + +T + V F H Sbjct: 65 LVGGGKKKVMIWDDLKKKTVIEIEFSTEVKAVKLRRDRIVVVLDSMIKVFTFTHNPHQLH 124 Query: 128 VSTVSVLSSGT-----------QAVSGSKDICIKVWDLA-QQVVLSSYRAHAAQVTCVAA 175 V G A G+ +++ DLA + AH ++C+A Sbjct: 125 VFETCYNPKGLCVLCPNSNNSLLAFPGTHTGHVQLVDLASTEKPPVDIPAHEGVLSCIAL 184 Query: 176 SPHKDSVFLSCSEDNR-ILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDEN 234 + + + SE I ++DT ++ + + ++ Q + + ++ Sbjct: 185 NLQGTRI-ATASEKGTLIRIFDTSSGHLIQELRRGSQAANIYCINFN-QDASLICVSSDH 242 Query: 235 GTVSLV---DTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCS 279 GTV + D KS V S F + ++ D S Sbjct: 243 GTVHIFAAEDPKSKWSFSKFQVPSGSPCICAFG-TEPNAVIAICADGS 289 >5WLC-LH nrPDB Length = 896 Score = 48.2 bits (113), Expect = 5e-06, Method: Composition-based stats. Identities = 17/79 (21%), Positives = 30/79 (37%), Gaps = 2/79 (2%) Query: 124 HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVF 183 + VS++++ + G Q G I + LA + + H V ++ S H S Sbjct: 255 NTRYVSSMAIDNMGQQLAVGFASGVISIVSLADLQ-IRLLKWHIDSVLSLSFS-HDGSYL 312 Query: 184 LSCSEDNRILLWDTRCPKP 202 LS + + LW Sbjct: 313 LSGGWEKVMSLWQLETNSQ 331 >4FHN-A nrPDB Length = 394 Score = 47.4 bits (111), Expect = 8e-06, Method: Composition-based stats. Identities = 21/147 (14%), Positives = 47/147 (31%), Gaps = 11/147 (7%) Query: 166 HAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQI---GCSAPGYLPTSLAW-- 220 H V +SP +DN + L T+ +Q G S + Sbjct: 89 HDGDGN-VNSSPVYSLFLACVCQDNTVRLIITKNETIITQHVLGGKSGHHNFVNDIDIAD 147 Query: 221 -----HPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLS 275 + +V ++ T+ + +L+ S + F P + L Sbjct: 148 VYSADNRLAEQVIASVGDDCTLIIWRLTDEGPILAGYPLSSPGISVQFRPSNPNQLIVGE 207 Query: 276 EDCSLAVLDSSLSELFRSQAHRDFVRD 302 + ++ + D +L+ + + V++ Sbjct: 208 RNGNIRIFDWTLNLSAEENSQTELVKN 234 >5WLC-LV nrPDB Length = 707 Score = 46.7 bits (109), Expect = 1e-05, Method: Composition-based stats. Identities = 29/235 (12%), Positives = 83/235 (35%), Gaps = 19/235 (8%) Query: 109 DENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAA 168 ++ ++ K+ + + V+ V S + ++ +L + L+ ++ Sbjct: 127 NKGGLHYTTRIPKFGRSLVYNKVNC----DLYVGASGNELYRL-NLEKGRFLNPFKLDTE 181 Query: 169 QVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQI----GCSAPGYLPTSLAWHPQQ 224 V V+ + + + +E N + WD R S++ + T+ ++ Sbjct: 182 GVNHVSINEVNG-LLAAGTETNVVEFWDPRSRSRVSKLYLENNIDNRPFQVTTTSFR-ND 239 Query: 225 SEVFVFGDENGTVSLVDTKSTSC-VLSSAVHSQCVTGLVF--SPHSVPFLASLSEDCSL- 280 F G NG + D +++ ++ + + +++ + + + + D + Sbjct: 240 GLTFACGTSNGYSYIYDLRTSEPSIIKDQGYGFDIKKIIWLDNVGTENKIVTC--DKRIA 297 Query: 281 AVLDSSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQVVHHVVPTEPLPAP 335 + D + + S + D P + T + + +P+ P+P Sbjct: 298 KIWDRLDGKAYASMEPSVDINDIEHVP-GTGMFFTANESIPMHTYYIPSLG-PSP 350 >2VDU-B nrPDB Length = 450 Score = 46.3 bits (108), Expect = 2e-05, Method: Composition-based stats. Identities = 21/124 (16%), Positives = 49/124 (39%), Gaps = 6/124 (4%) Query: 91 ERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGT---QAVSGSKDI 147 + +++A G V +++ ++ H +++ V ++ ++ +D Sbjct: 161 DTTVIIADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDE 220 Query: 148 CIKVWDLAQQVVLSS-YRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQI 206 IK+ Q ++ H V+ + KD + LS D++I WD + K S Sbjct: 221 HIKISHYPQCFIVDKWLFGHKHFVSSICC--GKDYLLLSAGGDDKIFAWDWKTGKNLSTF 278 Query: 207 GCSA 210 ++ Sbjct: 279 DYNS 282 >2I3T-A nrPDB Length = 341 Score = 45.9 bits (107), Expect = 3e-05, Method: Composition-based stats. Identities = 36/209 (17%), Positives = 72/209 (34%), Gaps = 29/209 (13%) Query: 137 GTQAVSGSKDICIKVWDLAQQ----VVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRI 192 + ++ S D I+V D + + + ++ +V + +S L +N Sbjct: 112 DDKLIAASWDGLIEVIDPRNYGDGVIAVKNLNSNNTKVKNKIFTMDTNSSRLIVGMNNSQ 171 Query: 193 LLWDTRCP---KPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLV------DTK 243 + W R P I S Y +A P++ E + +G V++ D Sbjct: 172 VQW-FRLPLCEDDNGTIEESGLKYQIRDVALLPKEQEGYACSSIDGRVAVEFFDDQGDDY 230 Query: 244 STSCVLSSAVH---------SQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQ 294 ++S + H + V + FSP FL + D ++ + + ++ Sbjct: 231 NSSKRFAFRCHRLNLKDTNLAYPVNSIEFSPRH-KFLYTAGSDGIISCWNLQTRKKIKNF 289 Query: 295 A--HRDFVRDATWSPLNHSLLTTVGWDHQ 321 A + D V S ++L D Sbjct: 290 AKFNEDSVVKIACS---DNILCLATSDDT 315 Score = 45.5 bits (106), Expect = 3e-05, Method: Composition-based stats. Identities = 17/122 (13%), Positives = 43/122 (35%), Gaps = 16/122 (13%) Query: 82 GVADLTWVGERGILVASD--SGAVEL--WELDENETLIVSKFCKYEHD---------DIV 128 + D+ + + A G V + ++ ++ +F H V Sbjct: 195 QIRDVALLPKEQEGYACSSIDGRVAVEFFDDQGDDYNSSKRFAFRCHRLNLKDTNLAYPV 254 Query: 129 STVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSY-RAHAAQVTCVAASPHKDSVFLSCS 187 +++ + D I W+L + + ++ + + V +A S + + L+ S Sbjct: 255 NSIEFSPRHKFLYTAGSDGIISCWNLQTRKKIKNFAKFNEDSVVKIACS--DNILCLATS 312 Query: 188 ED 189 +D Sbjct: 313 DD 314 Score = 40.9 bits (94), Expect = 9e-04, Method: Composition-based stats. Identities = 28/211 (13%), Positives = 66/211 (31%), Gaps = 16/211 (7%) Query: 125 DDIVSTVSVLSSGTQAVSGSKDICIKVW--DLAQQV--VLSSYRAHAAQVTCVAASPHKD 180 D +S + ++ S + + S D + V+ D+ + +L S R + + C + D Sbjct: 11 KDYISDIKIIPSKSLLLITSWDGSLTVYKFDIQAKNVDLLQSLR-YKHPLLCCNFIDNTD 69 Query: 181 SVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLV 240 + IL D + + + + + + +G + ++ Sbjct: 70 LQIYVGTVQGEILKVDLIGSPSFQALTNNEANLGICRICKY--GDDKLIAASWDGLIEVI 127 Query: 241 DTKSTS----CVLSSAVHSQCVTGLVFS-PHSVPFLASLSEDCSLAVLDSSLSE----LF 291 D ++ V + ++ V +F+ + L + + L E Sbjct: 128 DPRNYGDGVIAVKNLNSNNTKVKNKIFTMDTNSSRLIVGMNNSQVQWFRLPLCEDDNGTI 187 Query: 292 RSQAHRDFVRDATWSPLNHSLLTTVGWDHQV 322 + +RD P D +V Sbjct: 188 EESGLKYQIRDVALLPKEQEGYACSSIDGRV 218 >6NAU-A nrPDB Length = 334 Score = 41.6 bits (96), Expect = 5e-04, Method: Composition-based stats. Identities = 38/242 (15%), Positives = 77/242 (31%), Gaps = 49/242 (20%) Query: 67 APNEGFCSAGVQTEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDD 126 +PN+ F GV+ E V + G L + A+ + H Sbjct: 47 SPNKEFLYVGVRPEFRVLAYRITPDNGALTFAGEAAL---------PGSPTHISTDRHGR 97 Query: 127 IVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRA-HAAQV---TCVAASP---HK 179 V + S G +V+ D V+ H+A + P Sbjct: 98 FVFSASYNQ-GCVSVTPLHDGL----PGETITVVEGLEGCHSANISPDNRTLWVPALKQD 152 Query: 180 DSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSL 239 + S+D + + P + + + P ++ +HP Q + + N ++ + Sbjct: 153 RICLFTLSDDGFL---SAQEPAEVTTVEGAGPRHMV----FHPNQQYGYCVNELNSSIDV 205 Query: 240 VDTK----STSCVLSSAVHSQCVTGLVFS------PHSVPF-----------LASLSEDC 278 + K + CV + + +G+ ++ P + S+SED Sbjct: 206 WELKDPKGNIECVQTLDMMPPDFSGVRWAADIHITPDGRHLYACDRTASIITVFSVSEDG 265 Query: 279 SL 280 S+ Sbjct: 266 SV 267 >5WLC-LL nrPDB Length = 643 Score = 41.6 bits (96), Expect = 5e-04, Method: Composition-based stats. Identities = 24/149 (16%), Positives = 60/149 (40%), Gaps = 20/149 (13%) Query: 104 ELWELDENETLIVS---KFCKYEHDDIVSTVSVL-----SSGT---QAVSGSKDICIKVW 152 +LW +D ++ +F +H I + V + +G Q + S I + Sbjct: 116 QLWCIDSSDAFYQFDLLQFKLLQHFRINNCVQLNKLTIVPAGDSVAQLLVAS--HSISLI 173 Query: 153 DLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSE-DNRILLWDTRCPKPASQIGCSAP 211 D+ ++ V+ ++ H + V+ + ++ F+S +E D + ++D + + Sbjct: 174 DIEEKKVVMTFPGHVSPVSTLQVITNE--FFISGAEGDRFLNVYDIHSGMTKCVLVAESD 231 Query: 212 GYLPTSLAWHPQQSEVFVFGDENGTVSLV 240 + H Q++ E+G++ + Sbjct: 232 IKELS----HSGQADSIAVTTEDGSLEIF 256 >6N8P-A nrPDB Length = 979 Score = 40.9 bits (94), Expect = 7e-04, Method: Composition-based stats. Identities = 38/258 (14%), Positives = 67/258 (25%), Gaps = 67/258 (25%) Query: 91 ERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIK 150 IL+ G V +W+L + L F + + + G VS D Sbjct: 190 PNQILIGYSRGLVVIWDLQGSRVLY--HFLSSQQLENIW---WQRDGRLLVSCHSDGSYC 244 Query: 151 VW----DLAQQVVLSSYRAHA----AQVTCVAA------------------SPHKDSVFL 184 W + Q L S + +T + + + D + Sbjct: 245 QWPVSSEAQQPEPLRSLVPYGPFPCKAITRILWLTTRQGLPFTIFQGGMPRASYGDRHCI 304 Query: 185 SCSEDNRILLWDTRC-----------------PKPASQIGCSAPGYLPTSLA---WHPQQ 224 S D + +D P + + + + L W P Q Sbjct: 305 SVIHDGQQTAFDFTSRVIGFTVLTEADPAATFDDPYALVVLAEEELVVIDLQTAGWPPVQ 364 Query: 225 SEVFVF----------GDENGTVSLVDTKSTSCVLSSAVHS------QCVTGLVFSPHSV 268 N + L + + +A S T L +P Sbjct: 365 LPYLASLHCSAITCSHHVSNIPLKLWERIIAAGSRQNAHFSTMEWPIDGGTSLTPAPPQR 424 Query: 269 PFLASLSEDCSLAVLDSS 286 L + ED ++ D+S Sbjct: 425 DLLLTGHEDGTVRFWDAS 442 Score = 39.7 bits (91), Expect = 0.002, Method: Composition-based stats. Identities = 38/250 (15%), Positives = 72/250 (28%), Gaps = 38/250 (15%) Query: 118 KFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRA-HAAQ--VTCVA 174 K ++ S + S G++ IK++ + H VT + Sbjct: 14 KTVEHGFPHQPSALGYSPSLRILAIGTRSGAIKLY----GAPGVEFMGLHQENNAVTQIH 69 Query: 175 ASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCS-----------APGYLPTSLAWHPQ 223 P + ++ +DN + LW + AS++ AP ++ Sbjct: 70 LLPGQCQ-LVTLLDDNSLHLWSLKVKGGASELQEDESFTLRGPPGAAPSATQITVVLPHS 128 Query: 224 QSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVT-----------------GLVFSPH 266 E+ G E+G V +V + + + S V L P Sbjct: 129 SCELLYLGTESGNVFVVQLPAFRALEDRTISSDAVLQRLPEEARHRRVFEMVEALQEHPR 188 Query: 267 SVPFLASLSEDCSLAVLDSSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQVVHHV 326 + + + D S + + + W + LL + D Sbjct: 189 DPNQILIGYSRGLVVIWDLQGSRVLYHFLSSQQLENIWWQ-RDGRLLVSCHSDGSYCQWP 247 Query: 327 VPTEP-LPAP 335 V +E P P Sbjct: 248 VSSEAQQPEP 257 Score = 33.6 bits (75), Expect = 0.12, Method: Composition-based stats. Identities = 17/94 (18%), Positives = 31/94 (32%), Gaps = 21/94 (22%) Query: 91 ERGILVASD---SGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDI 147 ER I S + W +D +L + ++G +D Sbjct: 391 ERIIAAGSRQNAHFSTMEWPIDGGTSLTPAP----------------PQRDLLLTGHEDG 434 Query: 148 CIKVWDLAQQVVLS-SYRAHAAQVTCVAASPHKD 180 ++ WD A V L Y+ +V P+++ Sbjct: 435 TVRFWD-ASGVCLRLLYKLSTVRVFLTDTDPNEN 467 >4YHC-A nrPDB Length = 468 Score = 40.5 bits (93), Expect = 0.001, Method: Composition-based stats. Identities = 18/104 (17%), Positives = 36/104 (34%), Gaps = 1/104 (0%) Query: 166 HAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQS 225 H + +A S + F S D +++WD R + ++A PQ + Sbjct: 29 HQLDILKIAVSENY-KTFASVGLDRSLVVWDLRQWCTKLVLSKEQMPRTLKAIALDPQGN 87 Query: 226 EVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVP 269 V +F + + V++ S S + + P + Sbjct: 88 YVSLFSKDTLFILNVESPSLMLQHSYHSKPNSKLNVFWMPGTHK 131 >5K1H-B nrPDB Length = 576 Score = 38.6 bits (88), Expect = 0.004, Method: Composition-based stats. Identities = 26/127 (20%), Positives = 46/127 (36%), Gaps = 6/127 (4%) Query: 197 TRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSL--VDTKSTSCVLSSAVH 254 R + + + AW P S+ V E +S+ KS + S + Sbjct: 378 FRMREKQVPVDVVEMKETIIAFAWEPNGSKFAVLHGEAPRISVSFYHVKSNGKIELSKMF 437 Query: 255 -SQCVTGLVFSPHSVPFLASL--SEDCSLAVLDSSLSELFRSQAHRDFVRDATWSPLNHS 311 Q + +SP + + S + +LA +D+S + H D W P Sbjct: 438 DKQQANTIFWSPQGQFVVLAGLRSMNGALAFVDTSDCTVMNIAEHY-MASDVEWDPTGRY 496 Query: 312 LLTTVGW 318 ++T+V W Sbjct: 497 VVTSVSW 503 >5GRS-A nrPDB Length = 396 Score = 38.6 bits (88), Expect = 0.005, Method: Composition-based stats. Identities = 21/106 (19%), Positives = 44/106 (41%), Gaps = 5/106 (4%) Query: 166 HAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQS 225 H + +A S + F S D +++WD R + ++A PQ + Sbjct: 29 HQLDILKIAVSENY-KTFASVGLDRCLVVWDLRQWCTKLVLSKEQMPRTLKAIALDPQGN 87 Query: 226 EVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLV--FSPHSVP 269 V +F + T+ +++ +S S +L + H + + L + P + Sbjct: 88 YVSLFSKD--TLFILNVESPSLMLQHSYHCKPNSKLNVFWMPGTHK 131 >5WLC-LS nrPDB Length = 594 Score = 37.8 bits (86), Expect = 0.006, Method: Composition-based stats. Identities = 19/121 (15%), Positives = 38/121 (31%), Gaps = 11/121 (9%) Query: 131 VSVLSSGTQAVSGSKDICIKVWDLA------QQVVLSSYRAHAAQVTCVAASPHKDSVFL 184 +S + GS+ + ++D +++ ++ + SP + Sbjct: 473 ISKIKQNRWLAVGSESGFVNLYDRNNAMTSSTPTPVAALDQLTTTISNLQFSPD-GQILC 531 Query: 185 SCSEDNRILLWDTRCPKPASQIGCSAPGYL---PTSLAWHPQQSEVFVFGDENGTVSLVD 241 S + L P + G TS+A+ P + G+E G V L Sbjct: 532 MASRAVKDALRLVHLPSCSVFSNWPTSGTPLGKVTSVAFSP-SGGLLAVGNEQGKVRLWK 590 Query: 242 T 242 Sbjct: 591 L 591 Score = 37.0 bits (84), Expect = 0.011, Method: Composition-based stats. Identities = 18/94 (19%), Positives = 32/94 (34%), Gaps = 7/94 (7%) Query: 207 GCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLV--DTKSTSCVLSSAVHSQCVTGLVF- 263 SL++HP + + G + T+ + D K+ V S + + F Sbjct: 243 ASHPSHSAIQSLSFHP-SKPLLLTGGYDKTLRIYHIDGKTNHLVTSLHLVGSPIQTCTFY 301 Query: 264 ---SPHSVPFLASLSEDCSLAVLDSSLSELFRSQ 294 S + + + + D SL L SQ Sbjct: 302 TSLSNQNQQNIFTAGRRRYMHSWDLSLENLTHSQ 335 Score = 36.6 bits (83), Expect = 0.014, Method: Composition-based stats. Identities = 10/82 (12%), Positives = 31/82 (37%), Gaps = 9/82 (10%) Query: 123 EHDDIVSTVSVLSSGTQAVSGSKDICIKVW--DLAQQVVLSSYRAHAAQVTCVAA----- 175 H + ++S S ++G D ++++ D +++S + + Sbjct: 247 SHS-AIQSLSFHPSKPLLLTGGYDKTLRIYHIDGKTNHLVTSLHLVGSPIQTCTFYTSLS 305 Query: 176 SPHKDSVFLSCSEDNRILLWDT 197 + ++ ++F + + WD Sbjct: 306 NQNQQNIF-TAGRRRYMHSWDL 326 Score = 33.9 bits (76), Expect = 0.097, Method: Composition-based stats. Identities = 14/61 (22%), Positives = 22/61 (36%), Gaps = 6/61 (9%) Query: 235 GTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVL--DSSLSELFR 292 + +V K + S + L F P S P L + D +L + D + L Sbjct: 231 KKLDIVRLKDANASHPSH---SAIQSLSFHP-SKPLLLTGGYDKTLRIYHIDGKTNHLVT 286 Query: 293 S 293 S Sbjct: 287 S 287 Score = 33.6 bits (75), Expect = 0.12, Method: Composition-based stats. Identities = 7/31 (22%), Positives = 15/31 (48%) Query: 126 DIVSTVSVLSSGTQAVSGSKDICIKVWDLAQ 156 V++V+ SG G++ +++W L Sbjct: 563 GKVTSVAFSPSGGLLAVGNEQGKVRLWKLNH 593 >1RI6-A nrPDB Length = 343 Score = 33.6 bits (75), Expect = 0.13, Method: Composition-based stats. Identities = 28/190 (14%), Positives = 63/190 (33%), Gaps = 42/190 (22%) Query: 126 DIVSTVSVLSSGTQAVSGSKD-ICIKVWDLAQQV------VLSSYRA-HAAQV---TCVA 174 ++ +S G GS + + V L + V+ H+A + Sbjct: 84 GSLTHISTDHQGQFVFVGSYNAGNVSVTRLEDGLPVGVVDVVEGLDGCHSANISPDNRTL 143 Query: 175 ASP---HKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFG 231 P + S+D ++ D P + + + P ++ +HP + + Sbjct: 144 WVPALKQDRICLFTVSDDGHLVAQD---PAEVTTVEGAGPRHMV----FHPNEQYAYCVN 196 Query: 232 DENGTVSLVDTK----STSCVLSSAVHSQCVTGLVFS------PHSVPF----------- 270 + N +V + + K + CV + + + + ++ P Sbjct: 197 ELNSSVDVWELKDPHGNIECVQTLDMMPENFSDTRWAADIHITPDGRHLYACDRTASLIT 256 Query: 271 LASLSEDCSL 280 + S+SED S+ Sbjct: 257 VFSVSEDGSV 266 >2FRX-A nrPDB Length = 479 Score = 32.4 bits (72), Expect = 0.26, Method: Composition-based stats. Identities = 25/110 (22%), Positives = 36/110 (32%), Gaps = 16/110 (14%) Query: 1 MRKETPPPLVPPAAREWNLPPNAPACMERQLEAARYRSDGALLLGASSLSGRCWA--GSL 58 +RK P +P + P +P +R+ R + G L +L R W L Sbjct: 308 LRKTQAIPALPAPKYKVGNFPFSPV-KDREAGQIRQAATGVGLNWDENL--RLWQRDKEL 364 Query: 59 WLFKDPCAAPNEGFCSAGVQTEAGVADLT-------WVGERGILVASDSG 101 WLF P E + G+ W E I +AS Sbjct: 365 WLF--PVGI--EALIGKVRFSRLGIKLAETHNKGYRWQHEAVIALASPDN 410 >6GC1-A nrPDB Length = 579 Score = 32.4 bits (72), Expect = 0.28, Method: Composition-based stats. Identities = 24/156 (15%), Positives = 46/156 (29%), Gaps = 26/156 (16%) Query: 109 DENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAA 168 +EN + +S S V+ S+ ++ L V Sbjct: 403 EENRNNAYPHKAGFAQPSGLSLASEDPWSCLFVADSESSTVRTVSLKDGAVKHLVGGERD 462 Query: 169 QVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVF 228 + A D +G +A P + W +++ ++ Sbjct: 463 PMNLFAF----------GDVDG---------------VGINAKLQHPLGVTWDKKRNLLY 497 Query: 229 VFGDENGTVSLVDTKSTSC-VLSSAVHSQCVTGLVF 263 V N + +VD K+ +C L+ + VT F Sbjct: 498 VADSYNHKIKVVDPKTKNCTTLAGTGDTNNVTSSSF 533 >4R40-A nrPDB Length = 411 Score = 32.0 bits (71), Expect = 0.41, Method: Composition-based stats. Identities = 25/138 (18%), Positives = 46/138 (33%), Gaps = 12/138 (8%) Query: 190 NRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEV----FVFGDENGTVSLVDTKST 245 + + + D P P AW P S++ F G + + + Sbjct: 161 HELRVSDYDGYNQFVVHRSPEPLMSP---AWSPDGSKIAYVTFESGKSALVIQTLANGAI 217 Query: 246 SCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVL--DSSLSELFRSQAHRDFVRDA 303 V S H+ FSP +LS+ SL + D + ++ + R + Sbjct: 218 RQVASFPRHNG---APAFSPDGTKLAFALSKSGSLNLYVMDLASGQISQVTDGRSNNTEP 274 Query: 304 TWSPLNHSLLTTVGWDHQ 321 +W P + +L T + Sbjct: 275 SWFPDSQNLAYTSDQGGR 292 >3UBH-A nrPDB Length = 419 Score = 30.1 bits (66), Expect = 1.3, Method: Composition-based stats. Identities = 10/66 (15%), Positives = 21/66 (31%), Gaps = 3/66 (4%) Query: 170 VTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFV 229 V + + +DS S S D I + D P ++ + + P + + Sbjct: 290 VYSLIVTATEDSGGFSTSVDLTIRVTDVNDNAPKFELPDYQAHNVDEDI---PLGTSILR 346 Query: 230 FGDENG 235 + Sbjct: 347 VKAMDS 352 >5IV7-F nrPDB Length = 288 Score = 30.1 bits (66), Expect = 1.6, Method: Composition-based stats. Identities = 21/95 (22%), Positives = 40/95 (42%), Gaps = 14/95 (14%) Query: 232 DENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELF 291 + NG++S+ + + + S S +V SP+S L +S D S +V + S+ +F Sbjct: 111 NSNGSISVTNPLTIQAIDSIKGVSG--NLVVTSPYSKVTLRCISSDNSTSVWNYSIESMF 168 Query: 292 RSQAHRDFVRDATWSPLNHS--LLTTVGWDHQVVH 324 + SP + + T+ D + H Sbjct: 169 GQKE----------SPAEGTWNISTSGSVDIPLFH 193 >4NOX-A nrPDB Length = 746 Score = 30.1 bits (66), Expect = 1.6, Method: Composition-based stats. Identities = 16/96 (16%), Positives = 29/96 (30%), Gaps = 24/96 (25%) Query: 86 LTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGS- 144 + W L + + V+LW S+ ++ H V+ V+ V+ S Sbjct: 204 VQWSPLGTYLTSVHAQGVQLW-----GGASWSRLRRFPHP-FVNLVAFSPGEKYLVTWSN 257 Query: 145 ----------------KDIC-IKVWDLAQQVVLSSY 163 D +WD+ L S+ Sbjct: 258 RPIQIPDSGHPVLTLDDDGKNYIIWDIETARPLRSF 293 >5W0U-B nrPDB Length = 549 Score = 29.7 bits (65), Expect = 1.7, Method: Composition-based stats. Identities = 19/98 (19%), Positives = 33/98 (33%), Gaps = 15/98 (15%) Query: 32 EAARYRSDGALLLGASSLSGRCWAGSLWLFKDPCAAPNEGFCSAGVQTEAGVADLTWVGE 91 + AR+ +D L G +LS R + L+ +D A P G+ L G Sbjct: 457 DCARHVAD--FLRGNPNLSLRIFTARLYFCEDRKAEPE------------GLRRLAEAGV 502 Query: 92 RGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVS 129 + ++ W K + H++ V Sbjct: 503 QIAIMTYKDYEYC-WNTFVENHERTFKAWEGLHENSVR 539 >1OGY-B nrPDB Length = 130 Score = 29.7 bits (65), Expect = 1.8, Method: Composition-based stats. Identities = 18/75 (24%), Positives = 31/75 (41%), Gaps = 19/75 (25%) Query: 7 PPLVPPAAREWNLPPNAPACMERQLEAARYRSDGALLLGASSLSGRCWAGSLWLFKDPCA 66 PP++P + + L NA C+E +R + L+ A + S+ F+D Sbjct: 39 PPVIPHSIEGYQLSVNANRCLEC------HRRQYSGLVAAPMI-------SITHFQDREG 85 Query: 67 ------APNEGFCSA 75 +P FC+A Sbjct: 86 QMLADVSPRRYFCTA 100 >1KHE-A nrPDB Length = 625 Score = 29.7 bits (65), Expect = 1.9, Method: Composition-based stats. Identities = 16/51 (31%), Positives = 22/51 (43%), Gaps = 4/51 (7%) Query: 46 ASSLSGRCWAGSLWLFKD--PCAAPNEGFCSAGVQTEAGVADLTWVGERGI 94 AS ++ W W +D PCA PN FC+ Q + D W G+ Sbjct: 381 ASGVTITSWKNKEWSSEDGEPCAHPNSRFCTPASQ--CPIIDAAWESPEGV 429 >4GMM-A nrPDB Length = 612 Score = 28.9 bits (63), Expect = 2.9, Method: Composition-based stats. Identities = 15/51 (29%), Positives = 21/51 (41%), Gaps = 4/51 (7%) Query: 46 ASSLSGRCWAGSLWLFKD--PCAAPNEGFCSAGVQTEAGVADLTWVGERGI 94 A ++ W W +D PCA PN FC+ Q + D W G+ Sbjct: 378 APGVTITSWKNKEWRPQDEEPCAHPNSRFCTPASQ--CPIIDPAWESPEGV 426 >1Z68-A nrPDB Length = 719 Score = 28.6 bits (62), Expect = 3.8, Method: Composition-based stats. Identities = 18/119 (15%), Positives = 39/119 (32%), Gaps = 13/119 (10%) Query: 224 QSEVFVFGDENGTVSLVDTKSTSCVLSSAVHS-QCVTGLVF--SPHSVPF--------LA 272 + ++ + + L + ++ + + + V + SP L Sbjct: 25 SGQEYLHQSADNNIVLYNIETGQSYTILSNRTMKSVNASNYGLSPDRQFVYLESDYSKLW 84 Query: 273 SLSEDCSLAVLDSSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQVVHHVVPTEP 331 S + + D S E R ++ WSP+ S L V + + + P +P Sbjct: 85 RYSYTATYYIYDLSNGEFVRGNELPRPIQYLCWSPV-GSKLAYV-YQNNIYLKQRPGDP 141 >4TLF-A nrPDB Length = 211 Score = 27.4 bits (59), Expect = 8.4, Method: Composition-based stats. Identities = 10/56 (17%), Positives = 20/56 (35%), Gaps = 2/56 (3%) Query: 243 KSTSCVLSSAVHSQCVTGLVFSPHSV--PFLASLSEDCSLAVLDSSLSELFRSQAH 296 +++ + + V VFS PF++ S + D S + +H Sbjct: 151 RTSISIHVYGANIGAVRRAVFSAEGEEKPFISGYSNSRLPNIWDLSKENPASAWSH 206 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.307 0.128 0.380 Lambda K H 0.267 0.0389 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 13,417,194 Number of Sequences: 36641 Number of extensions: 470432 Number of successful extensions: 4538 Number of sequences better than 10.0: 163 Number of HSP's better than 10.0 without gapping: 217 Number of HSP's successfully gapped in prelim test: 67 Number of HSP's that attempted gapping in prelim test: 1423 Number of HSP's gapped (non-prelim): 979 length of query: 342 length of database: 10,336,785 effective HSP length: 98 effective length of query: 244 effective length of database: 6,745,967 effective search space: 1646015948 effective search space used: 1646015948 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.1 bits) S2: 59 (27.4 bits)