BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q99986 (396 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 2RSV-A nrPDB 822 0.0 2LAV-A nrPDB 751 0.0 5UU1-A nrPDB 347 4e-96 2JII-A nrPDB 211 5e-55 5X18-A nrPDB 128 4e-30 4TN6-A nrPDB 128 5e-30 3SV0-A nrPDB 123 2e-28 5FQD-C nrPDB 119 3e-27 4NT4-A nrPDB 116 1e-26 2C47-A nrPDB 114 7e-26 1CSN-A nrPDB 113 1e-25 2CMW-A nrPDB 113 2e-25 2CHL-A nrPDB 109 2e-24 4XHL-A nrPDB 108 3e-24 4XHH-A nrPDB 107 9e-24 4BTK-A nrPDB 92 3e-19 4NFN-A nrPDB 92 4e-19 4NST-A nrPDB 54 1e-07 4UZD-A nrPDB 53 3e-07 5EFQ-A nrPDB 52 4e-07 3D2K-A nrPDB 52 6e-07 4I6B-A nrPDB 49 4e-06 4Y83-A nrPDB 49 5e-06 2GCD-A nrPDB 48 7e-06 1U5R-A nrPDB 48 7e-06 1KOB-A nrPDB 48 8e-06 5JN2-A nrPDB 47 1e-05 5UV4-A nrPDB 47 1e-05 4YNZ-A nrPDB 47 2e-05 5XZW-A nrPDB 46 2e-05 4B8L-A nrPDB 45 4e-05 1UA2-A nrPDB 45 5e-05 3MA6-A nrPDB 45 7e-05 5B2L-A nrPDB 45 8e-05 3DB8-A nrPDB 44 8e-05 4YZB-A nrPDB 44 1e-04 4C0T-A nrPDB 44 1e-04 4QTB-A nrPDB 44 1e-04 3ORP-A nrPDB 44 1e-04 4PDS-A nrPDB 44 1e-04 2WTK-C nrPDB 43 3e-04 3COM-A nrPDB 42 3e-04 5LOH-A nrPDB 42 4e-04 1V0B-A nrPDB 42 5e-04 5J0A-A nrPDB 42 5e-04 5VO2-A nrPDB 42 5e-04 1VZO-A nrPDB 42 6e-04 3HZT-A nrPDB 42 6e-04 1KOA-A nrPDB 42 6e-04 3UTO-A nrPDB 42 6e-04 2OU7-A nrPDB 42 6e-04 4J52-A nrPDB 42 6e-04 5L2Q-C nrPDB 41 7e-04 3LIJ-A nrPDB 41 7e-04 4JG6-A nrPDB 41 7e-04 4IC8-A nrPDB 41 8e-04 5J5T-A nrPDB 41 8e-04 4IDT-A nrPDB 41 8e-04 3ORZ-A nrPDB 41 9e-04 2HK5-A nrPDB 41 9e-04 4JXF-A nrPDB 41 0.001 3NCG-A nrPDB 41 0.001 4G3E-A nrPDB 41 0.001 3IS5-A nrPDB 41 0.001 3DFA-A nrPDB 40 0.001 3DXN-A nrPDB 40 0.001 4QMW-A nrPDB 40 0.001 5NGU-A nrPDB 40 0.001 3FXW-A nrPDB 40 0.001 4MYG-A nrPDB 40 0.002 2X4F-A nrPDB 40 0.002 3Q5I-A nrPDB 40 0.002 4ZSG-A nrPDB 39 0.003 5HI2-A nrPDB 39 0.003 1S9I-A nrPDB 39 0.003 2Z7Q-A nrPDB 39 0.003 2BRG-A nrPDB 39 0.004 5D9K-A nrPDB 39 0.004 2J90-A nrPDB 39 0.004 4L42-A nrPDB 39 0.004 4FZF-B nrPDB 39 0.004 1G3N-A nrPDB 39 0.004 3AOX-A nrPDB 39 0.005 6DBN-A nrPDB 39 0.005 1AD5-A nrPDB 39 0.005 3BBT-B nrPDB 39 0.005 1FOT-A nrPDB 39 0.005 2JDO-A nrPDB 39 0.006 2PL0-A nrPDB 39 0.006 3GC9-A nrPDB 39 0.006 3KN6-A nrPDB 38 0.006 4EQM-A nrPDB 38 0.006 3OHT-A nrPDB 38 0.006 4MVF-A nrPDB 38 0.006 4RGJ-A nrPDB 38 0.006 6CQF-A nrPDB 38 0.007 3Q53-A nrPDB 38 0.007 4RLP-A nrPDB 38 0.007 5Y86-A nrPDB 38 0.008 2V7O-A nrPDB 38 0.008 5KKR-C nrPDB 38 0.008 5IG1-A nrPDB 38 0.008 3HKO-A nrPDB 38 0.008 1ZWS-A nrPDB 38 0.009 2BPM-A nrPDB 38 0.009 2F57-A nrPDB 38 0.009 6DTL-A nrPDB 38 0.010 4AN9-A nrPDB 38 0.010 2YAB-A nrPDB 37 0.010 4EWQ-A nrPDB 37 0.010 4NIF-A nrPDB 37 0.010 2A27-A nrPDB 37 0.011 6AO5-A nrPDB 37 0.011 3EQC-A nrPDB 37 0.012 3F3Z-A nrPDB 37 0.014 5XVU-A nrPDB 37 0.014 3PP0-A nrPDB 37 0.014 5FET-A nrPDB 37 0.014 4LG4-A nrPDB 37 0.014 3H4J-B nrPDB 37 0.015 2PZI-A nrPDB 37 0.015 4Y12-A nrPDB 37 0.016 4CQG-A nrPDB 37 0.016 4CZT-A nrPDB 37 0.016 5ZTN-A nrPDB 37 0.017 3LMG-A nrPDB 37 0.018 4FR4-A nrPDB 37 0.018 3LM0-A nrPDB 37 0.020 6FD3-A nrPDB 37 0.020 2Y7J-A nrPDB 37 0.020 3M42-A nrPDB 37 0.021 4KRC-A nrPDB 37 0.022 3KA0-A nrPDB 36 0.022 2XIK-A nrPDB 36 0.022 1NY3-A nrPDB 36 0.023 6DBM-A nrPDB 36 0.023 2OZA-A nrPDB 36 0.023 4AU8-A nrPDB 36 0.024 5DYK-A nrPDB 36 0.025 4FG9-A nrPDB 36 0.027 3OZ6-A nrPDB 36 0.027 4JRN-A nrPDB 36 0.029 5DMZ-A nrPDB 36 0.031 3MIA-A nrPDB 36 0.031 4AW2-A nrPDB 36 0.032 5D7A-A nrPDB 36 0.035 3NIZ-A nrPDB 36 0.038 3MN3-A nrPDB 36 0.038 3UIU-A nrPDB 35 0.038 4REW-A nrPDB 35 0.039 3A8W-A nrPDB 35 0.039 5LPZ-A nrPDB 35 0.039 6F3F-A nrPDB 35 0.041 4E93-A nrPDB 35 0.042 1PHK-A nrPDB 35 0.044 2W4O-A nrPDB 35 0.047 4TNB-A nrPDB 35 0.053 4OLI-A nrPDB 35 0.053 4CFF-A nrPDB 35 0.053 6CCF-A nrPDB 35 0.055 3NIE-A nrPDB 35 0.056 4CFH-A nrPDB 35 0.061 3GUB-A nrPDB 35 0.061 4E7W-A nrPDB 35 0.063 4B6L-A nrPDB 35 0.065 1BYG-A nrPDB 35 0.066 1K9A-A nrPDB 35 0.070 5EZV-A nrPDB 35 0.072 1CM8-A nrPDB 35 0.074 4RED-A nrPDB 35 0.076 3ENH-A nrPDB 35 0.077 5WNO-A nrPDB 35 0.079 2QNJ-A nrPDB 35 0.079 4APC-A nrPDB 35 0.082 3DAK-A nrPDB 35 0.084 4KIK-B nrPDB 34 0.085 5UIU-A nrPDB 34 0.088 6C9D-A nrPDB 34 0.091 5U6C-A nrPDB 34 0.093 4UY9-A nrPDB 34 0.094 4F9B-A nrPDB 34 0.095 4D2V-A nrPDB 34 0.095 4BGQ-A nrPDB 34 0.10 4U41-A nrPDB 34 0.10 3TXO-A nrPDB 34 0.10 5AIR-A nrPDB 34 0.11 3IO7-A nrPDB 34 0.11 2WQN-A nrPDB 34 0.11 3BGP-A nrPDB 34 0.11 2VD5-A nrPDB 34 0.11 5TUR-A nrPDB 34 0.11 4RC3-A nrPDB 34 0.11 5LPV-A nrPDB 34 0.12 4XI2-A nrPDB 34 0.12 6E2O-A nrPDB 34 0.12 2UV2-A nrPDB 34 0.13 4M7I-A nrPDB 34 0.13 6NPU-A nrPDB 34 0.13 5ES1-A nrPDB 34 0.14 4XEY-B nrPDB 33 0.15 2XYN-A nrPDB 33 0.15 2H8H-A nrPDB 33 0.15 5H2U-A nrPDB 33 0.15 4UYA-A nrPDB 33 0.15 6EWX-A nrPDB 33 0.15 2W1I-A nrPDB 33 0.16 6QAU-A nrPDB 33 0.17 4CRL-A nrPDB 33 0.17 6E4F-A nrPDB 33 0.17 4H1J-A nrPDB 33 0.18 3HMP-A nrPDB 33 0.18 2BDW-A nrPDB 33 0.18 6GVJ-A nrPDB 33 0.19 5G6V-A nrPDB 33 0.19 6E9W-A nrPDB 33 0.19 5YKS-A nrPDB 33 0.19 6FDY-U nrPDB 33 0.20 3TKU-A nrPDB 33 0.20 4E20-A nrPDB 33 0.21 2A1A-B nrPDB 33 0.21 4Y93-A nrPDB 33 0.21 5FG8-A nrPDB 33 0.22 2JAM-A nrPDB 33 0.22 5GNK-A nrPDB 33 0.23 4LRM-A nrPDB 33 0.23 3EB0-A nrPDB 33 0.25 5AP3-A nrPDB 33 0.25 3PVW-A nrPDB 33 0.25 3LZB-A nrPDB 33 0.25 3KK8-A nrPDB 33 0.25 1TKI-A nrPDB 33 0.26 2I6L-A nrPDB 33 0.26 3VN9-A nrPDB 33 0.27 2YZA-A nrPDB 33 0.27 3HDN-A nrPDB 33 0.27 5U6B-A nrPDB 33 0.28 2ZMD-A nrPDB 33 0.28 6BXI-A nrPDB 33 0.28 2HAK-A nrPDB 33 0.29 4MD7-E nrPDB 33 0.29 5UUU-A nrPDB 32 0.32 4LFI-A nrPDB 32 0.32 3QUP-A nrPDB 32 0.32 2FO0-A nrPDB 32 0.34 4WB7-A nrPDB 32 0.35 5OAT-A nrPDB 32 0.39 4AF3-A nrPDB 32 0.39 3DTC-A nrPDB 32 0.39 5X3F-B nrPDB 32 0.40 3PLS-A nrPDB 32 0.42 6ED6-A nrPDB 32 0.44 5Z33-A nrPDB 32 0.45 6BDL-A nrPDB 32 0.46 5SYS-A nrPDB 32 0.46 5DBX-A nrPDB 32 0.47 3DZO-A nrPDB 32 0.48 3ZDU-A nrPDB 32 0.50 6BFN-A nrPDB 32 0.52 5L6P-A nrPDB 32 0.52 3FME-A nrPDB 32 0.53 2YCR-A nrPDB 32 0.56 3N9X-A nrPDB 32 0.59 2JC6-A nrPDB 32 0.59 4QNY-A nrPDB 32 0.61 2W96-B nrPDB 32 0.62 3OMV-A nrPDB 32 0.62 4KS7-A nrPDB 32 0.63 4IX6-A nrPDB 32 0.69 3UC3-A nrPDB 32 0.69 4HVI-A nrPDB 31 0.78 6EII-A nrPDB 31 0.78 3I6U-A nrPDB 31 0.80 2VWV-A nrPDB 31 0.80 5MJB-A nrPDB 31 0.84 4CI6-B nrPDB 31 0.85 6HMD-A nrPDB 31 0.86 6HXF-B nrPDB 31 0.89 1N8P-A nrPDB 31 0.89 3VHK-A nrPDB 31 0.92 5WAX-A nrPDB 31 0.95 3GQL-A nrPDB 31 0.96 5VE6-A nrPDB 31 0.97 5VDK-A nrPDB 31 0.98 5N23-A nrPDB 31 0.99 4NEU-A nrPDB 31 0.99 3BYV-A nrPDB 31 1.00 5AKB-A nrPDB 31 1.0 4EBW-A nrPDB 31 1.0 2VN9-A nrPDB 31 1.0 5HLW-A nrPDB 31 1.0 3TAC-A nrPDB 31 1.0 2J0K-A nrPDB 31 1.1 5U6Y-A nrPDB 31 1.1 5M07-A nrPDB 31 1.1 5X1R-A nrPDB 31 1.1 3BHH-A nrPDB 31 1.1 5KZ7-A nrPDB 31 1.2 3A4O-X nrPDB 31 1.2 2WTK-B nrPDB 31 1.2 2BUJ-A nrPDB 30 1.3 5HIE-A nrPDB 30 1.3 4X3F-A nrPDB 30 1.3 3CJF-A nrPDB 30 1.3 3HNG-A nrPDB 30 1.3 2VZ6-A nrPDB 30 1.4 5T88-A nrPDB 30 1.4 2W1Z-A nrPDB 30 1.5 4HZS-A nrPDB 30 1.5 1U54-B nrPDB 30 1.5 2F9G-A nrPDB 30 1.6 5YV8-A nrPDB 30 1.6 5A46-A nrPDB 30 1.6 2DQ7-X nrPDB 30 1.6 3QD2-B nrPDB 30 1.6 4OW8-A nrPDB 30 1.6 2PVN-A nrPDB 30 1.7 1JPA-A nrPDB 30 1.7 3UIM-A nrPDB 30 1.7 5XD6-A nrPDB 30 1.7 3GC0-A nrPDB 30 1.7 3C1X-A nrPDB 30 1.8 6G4J-A nrPDB 30 1.9 4BBM-A nrPDB 30 1.9 3NYO-A nrPDB 30 1.9 6CMJ-A nrPDB 30 1.9 3C51-A nrPDB 30 2.0 5USZ-A nrPDB 30 2.1 2PSQ-A nrPDB 30 2.2 6B2Q-A nrPDB 30 2.2 6J5U-C nrPDB 30 2.5 3TT0-A nrPDB 30 2.5 2Y6O-A nrPDB 30 2.7 5E8V-A nrPDB 29 3.0 5TQX-A nrPDB 29 3.0 3RP9-A nrPDB 29 3.0 3UDB-A nrPDB 29 3.0 4O2Z-A nrPDB 29 3.1 6GU6-A nrPDB 29 3.5 6O6Q-A nrPDB 29 3.5 4YHJ-A nrPDB 29 3.6 3PNU-A nrPDB 29 3.8 3SOA-A nrPDB 29 4.1 4AGU-A nrPDB 29 4.3 2PMN-X nrPDB 29 4.4 1FVR-A nrPDB 29 4.5 1C0L-A nrPDB 28 4.7 6GQK-A nrPDB 28 4.7 5JZN-A nrPDB 28 4.7 3SXS-A nrPDB 28 5.0 4FL3-A nrPDB 28 5.2 4C59-A nrPDB 28 5.3 4WNO-A nrPDB 28 5.6 3LXX-A nrPDB 28 5.9 1U59-A nrPDB 28 6.0 3PPZ-A nrPDB 28 6.4 4IPV-A nrPDB 28 6.8 4WWA-A nrPDB 28 7.3 5CLR-A nrPDB 28 7.7 3LLT-A nrPDB 28 7.8 1ZXE-A nrPDB 28 8.1 6CTH-A nrPDB 28 8.2 6CKI-A nrPDB 28 8.3 5C26-A nrPDB 28 8.3 5VC6-A nrPDB 28 8.6 1TLV-A nrPDB 28 9.5 3QA8-A nrPDB 28 9.9 3RAW-A nrPDB 28 10.0 >2RSV-A nrPDB Length = 403 Score = 822 bits (2124), Expect = 0.0, Method: Compositional matrix adjust. Identities = 396/396 (100%), Positives = 396/396 (100%) Query: 1 MPRVKAAQAGRQSSAKRHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSE 60 MPRVKAAQAGRQSSAKRHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSE Sbjct: 8 MPRVKAAQAGRQSSAKRHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSE 67 Query: 61 SVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHD 120 SVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHD Sbjct: 68 SVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHD 127 Query: 121 KNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKA 180 KNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKA Sbjct: 128 KNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKA 187 Query: 181 SNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSR 240 SNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSR Sbjct: 188 SNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSR 247 Query: 241 RGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIA 300 RGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIA Sbjct: 248 RGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIA 307 Query: 301 KYMETVKLLDYTEKPLYENLRDILLQGLKAIGSKDDGKLDLSVVENGGLKAKTITKKRKK 360 KYMETVKLLDYTEKPLYENLRDILLQGLKAIGSKDDGKLDLSVVENGGLKAKTITKKRKK Sbjct: 308 KYMETVKLLDYTEKPLYENLRDILLQGLKAIGSKDDGKLDLSVVENGGLKAKTITKKRKK 367 Query: 361 EIEESKEPGVEDTEWSNTQTEEAIQTRSRTRKRVQK 396 EIEESKEPGVEDTEWSNTQTEEAIQTRSRTRKRVQK Sbjct: 368 EIEESKEPGVEDTEWSNTQTEEAIQTRSRTRKRVQK 403 >2LAV-A nrPDB Length = 361 Score = 751 bits (1940), Expect = 0.0, Method: Compositional matrix adjust. Identities = 361/361 (100%), Positives = 361/361 (100%) Query: 1 MPRVKAAQAGRQSSAKRHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSE 60 MPRVKAAQAGRQSSAKRHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSE Sbjct: 1 MPRVKAAQAGRQSSAKRHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSE 60 Query: 61 SVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHD 120 SVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHD Sbjct: 61 SVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHD 120 Query: 121 KNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKA 180 KNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKA Sbjct: 121 KNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKA 180 Query: 181 SNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSR 240 SNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSR Sbjct: 181 SNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSR 240 Query: 241 RGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIA 300 RGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIA Sbjct: 241 RGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIA 300 Query: 301 KYMETVKLLDYTEKPLYENLRDILLQGLKAIGSKDDGKLDLSVVENGGLKAKTITKKRKK 360 KYMETVKLLDYTEKPLYENLRDILLQGLKAIGSKDDGKLDLSVVENGGLKAKTITKKRKK Sbjct: 301 KYMETVKLLDYTEKPLYENLRDILLQGLKAIGSKDDGKLDLSVVENGGLKAKTITKKRKK 360 Query: 361 E 361 E Sbjct: 361 E 361 >5UU1-A nrPDB Length = 324 Score = 347 bits (891), Expect = 4e-96, Method: Compositional matrix adjust. Identities = 172/303 (56%), Positives = 218/303 (71%), Gaps = 5/303 (1%) Query: 23 FAVGEIITDMAKKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLF 81 F G+++ DM +W +G IG GGFG IYLA N E DA VVKVE +NGPLF Sbjct: 4 FPEGKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNKPEK---DARHVVKVEYQENGPLF 60 Query: 82 TELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKI 141 +ELKFYQR AK + I+KWI ++L YLG+P ++GSGL + G+SYRFM+M+R G DLQKI Sbjct: 61 SELKFYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKI 120 Query: 142 YEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 N F + TVLQL +R+LD+LEYIHE+EYVHGDIKA+NLLL YKNPDQVYL DYGL+ Sbjct: 121 SGQNGT-FKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLS 179 Query: 202 YRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPW 261 YRYCP G HK+Y+E+P++ H+GTIEFTS+DAH GVA SRR D+EILGYCM++WL G LPW Sbjct: 180 YRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPW 239 Query: 262 EDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLR 321 E NLKDP V+ +K + + + K P + EIA+++ L Y EKP Y+ L+ Sbjct: 240 EQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALK 299 Query: 322 DIL 324 IL Sbjct: 300 KIL 302 >2JII-A nrPDB Length = 352 Score = 211 bits (537), Expect = 5e-55, Method: Compositional matrix adjust. Identities = 114/317 (35%), Positives = 173/317 (54%), Gaps = 11/317 (3%) Query: 21 EQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAP---CVVKVEPSDN 77 E G ++TD + ++WK+ + G +Y A S+ + S +K++ D Sbjct: 28 EALPTGTVLTDKSGRQWKLKSFQTRDNQGILYEAAPTSTLTCDSGPQKQKFSLKLDAKD- 86 Query: 78 GPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSD 137 G LF E F+QRAAKP Q+ KW + L +P G G+H YRF+++ G Sbjct: 87 GRLFNEQNFFQRAAKPLQVNKWKKLYSTPLLAIPTCMGFGVHQDK---YRFLVLPSLGRS 143 Query: 138 LQKIYEANAKR-FSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLV 196 LQ + + K S ++VLQ++ R+LD LE++HE+EYVHG++ A N+ ++ ++ QV L Sbjct: 144 LQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVDPEDQSQVTLA 203 Query: 197 DYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT 256 YG A+RYCP G H Y E + H+G +EF S+D H G PSRR DL+ LGYCM++WL Sbjct: 204 GYGFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMDLHKGCGPSRRSDLQSLGYCMLKWLY 263 Query: 257 GHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPL 316 G LPW + L + + + K ++ + + C + KY++ V L Y EKP Sbjct: 264 GFLPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGHWIRPSETLQKYLKVVMALTYEEKPP 323 Query: 317 YENLRD---ILLQGLKA 330 Y LR+ LLQ L+ Sbjct: 324 YAMLRNNLEALLQDLRV 340 >5X18-A nrPDB Length = 295 Score = 128 bits (321), Expect = 4e-30, Method: Compositional matrix adjust. Identities = 94/320 (29%), Positives = 159/320 (49%), Gaps = 51/320 (15%) Query: 36 EWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQ 95 +K+G IG+G FG ++ ++ + P +K EP R + Q Sbjct: 8 HYKIGKKIGEGSFGVLF-----EGTNMINGVPVAIKFEP--------------RKTEAPQ 48 Query: 96 IQKWIRTRKLKYLGVPK-----YWGS-GLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRF 149 ++ +T K+ G P Y+G GLH+ +++D G L+ +++ ++F Sbjct: 49 LRDEYKTYKILN-GTPNIPYAYYFGQEGLHN-------ILVIDLLGPSLEDLFDWCGRKF 100 Query: 150 SRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKN-PD--QVYLVDYGLA--YRY 204 S KTV+Q++++++ ++E +H H+ ++ DIK N L+ PD ++L+D+G+A YR Sbjct: 101 SVKTVVQVAVQMITLIEDLHAHDLIYRDIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRD 160 Query: 205 CPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDN 264 H Y+E K+ GT + SI+ H G SRR D+E LG+ +L GHLPW+ Sbjct: 161 PKTKQHIPYRE--KKSLSGTARYMSINTHLGREQSRRDDMEALGHVFFYFLRGHLPWQ-G 217 Query: 265 LKDP----KYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENL 320 LK P KY + + + N+ L + P + +Y+E V+ L + E P YE Sbjct: 218 LKAPNNKQKYEKIGEKKRSTNVYDL------AQGLPVQFGRYLEIVRSLSFEECPDYEGY 271 Query: 321 RDILLQGLKAIGSKDDGKLD 340 R +LL L +G DG+ D Sbjct: 272 RKLLLSVLDDLGETADGQYD 291 >4TN6-A nrPDB Length = 318 Score = 128 bits (321), Expect = 5e-30, Method: Compositional matrix adjust. Identities = 94/325 (28%), Positives = 150/325 (46%), Gaps = 33/325 (10%) Query: 37 WKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQ 95 +++G IG G FG IYL D+ + E V CV P L E K Y+ Sbjct: 9 YRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQ----LHIESKIYK------M 58 Query: 96 IQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVL 155 +Q + +++ G Y M+M+ G L+ ++ +++FS KTVL Sbjct: 59 MQGGVGIPTIRWCGAEG------------DYNVMVMELLGPSLEDLFNFCSRKFSLKTVL 106 Query: 156 QLSLRILDILEYIHEHEYVHGDIKASNLLLNY-KNPDQVYLVDYGLAYRYCPEGVHKEYK 214 L+ +++ +EYIH ++H D+K N L+ K + VY++D+GLA +Y H+ Sbjct: 107 LLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIP 166 Query: 215 EDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWED---NLKDPKYV 271 + GT + SI+ H G+ SRR DLE LGY ++ + G LPW+ K KY Sbjct: 167 YRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYE 226 Query: 272 RDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDILLQGLKAI 331 R S+ + I L C K P E A Y+ + L + +KP Y LR + Sbjct: 227 RISEKKMSTPIEVL---C---KGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQ 280 Query: 332 GSKDDGKLDLSVVENGGLKAKTITK 356 G D D ++++ G +A + + Sbjct: 281 GFSYDYVFDWNMLKFGASRAALVPR 305 >3SV0-A nrPDB Length = 483 Score = 123 bits (308), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 81/291 (27%), Positives = 139/291 (47%), Gaps = 27/291 (9%) Query: 36 EWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPE 94 ++++G IG G FG IYL ++ ++E V V P L E K Y+ Sbjct: 8 KFRLGRKIGSGSFGEIYLGTNIQTNEEVAIKLENVKTKHPQ----LLYESKIYR------ 57 Query: 95 QIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTV 154 +Q +++ GV Y ++MD G L+ ++ +++ S KTV Sbjct: 58 ILQGGTGIPNVRWFGVEG------------DYNVLVMDLLGPSLEDLFNFCSRKLSLKTV 105 Query: 155 LQLSLRILDILEYIHEHEYVHGDIKASNLLLNY-KNPDQVYLVDYGLAYRYCPEGVHKEY 213 L L+ ++++ +E++H ++H DIK N L+ + +QVY++D+GLA +Y H+ Sbjct: 106 LMLADQMINRVEFVHSKSFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDTSTHQHI 165 Query: 214 KEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRD 273 + GT + S++ H G+ SRR DLE LGY ++ +L G LPW+ K + Sbjct: 166 PYRENKNLTGTARYASVNTHLGIEQSRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKY 225 Query: 274 SKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDIL 324 KI ++ S+ C + P E A Y + L + +KP Y L+ + Sbjct: 226 EKISEKKVATSIEALC---RGYPTEFASYFHYCRSLRFDDKPDYSYLKRLF 273 >5FQD-C nrPDB Length = 341 Score = 119 bits (297), Expect = 3e-27, Method: Compositional matrix adjust. Identities = 98/344 (28%), Positives = 167/344 (48%), Gaps = 46/344 (13%) Query: 9 AGRQSSAKRHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAP 67 GR +S+ AE F VG ++K+ IG G FG IYLA ++ + E V Sbjct: 2 GGRMASSSGSKAE-FIVG--------GKYKLVRKIGSGSFGDIYLAINITNGEEV----- 47 Query: 68 CVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKY-LGVP--KYWGSGLHDKNGK 124 VK+E Q+A P+ + + + L+ +G+P +++G K Sbjct: 48 -AVKLES-------------QKARHPQLLYESKLYKILQGGVGIPHIRWYG------QEK 87 Query: 125 SYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLL 184 Y ++MD G L+ ++ ++RF+ KTVL L+ +++ +EY+H ++H DIK N L Sbjct: 88 DYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFL 147 Query: 185 LNY-KNPDQVYLVDYGLA--YRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRR 241 + ++ ++++L+D+GLA YR H Y+ED GT + SI+AH G+ SRR Sbjct: 148 MGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLT--GTARYASINAHLGIEQSRR 205 Query: 242 GDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAK 301 D+E LGY ++ + LPW+ K + KI ++ + C K P E A Sbjct: 206 DDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLC---KGFPAEFAM 262 Query: 302 YMETVKLLDYTEKPLYENLRDILLQGLKAIGSKDDGKLDLSVVE 345 Y+ + L + E P Y LR + + + + D D ++++ Sbjct: 263 YLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTMLK 306 >4NT4-A nrPDB Length = 312 Score = 116 bits (291), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 92/332 (27%), Positives = 153/332 (46%), Gaps = 45/332 (13%) Query: 24 AVGEIITDMAKKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEP--SDNGPL 80 A+ + M ++VG IG G FG + L ++ ++E V +K+EP S L Sbjct: 1 AMDPMAVLMVGPNFRVGKKIGCGNFGELRLGKNLYNNEHVA------IKMEPMKSKAPQL 54 Query: 81 FTELKFYQRAAK-----PEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFG 135 E +FY+ P+ G+P+ + G G Y M+++ G Sbjct: 55 HLEYRFYKLLGSHADNAPD--------------GIPRIYHLG---TCGGRYNAMVLELLG 97 Query: 136 SDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLL---NYKNPDQ 192 L+ ++ A++FS KTVL ++ ++L +EY+H ++ D+K N L+ + K Sbjct: 98 LSLEDLFNICARKFSLKTVLMIAKQLLHRIEYVHSRHLIYRDVKPENFLIGRTSTKREKI 157 Query: 193 VYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMI 252 ++++D+GLA Y ++ + GT + SI+ H G SRR DLE LG+ + Sbjct: 158 IHIIDFGLAKEYIDLDTNRHIPYREHKSLTGTARYMSINTHMGREQSRRDDLEALGHMFM 217 Query: 253 QWLTGHLPWE----DNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKL 308 +L G LPW+ D LK+ +Y + + I L D P E A Y+ V+ Sbjct: 218 YFLRGSLPWQGLKADTLKE-RYQKIGDTKRATPIEVLCD------GHPEEFATYLRYVRR 270 Query: 309 LDYTEKPLYENLRDILLQGLKAIGSKDDGKLD 340 LD+ E P Y+ LR + G D+G+ D Sbjct: 271 LDFFETPDYDFLRRLFQDLFDRKGYTDEGEFD 302 >2C47-A nrPDB Length = 313 Score = 114 bits (285), Expect = 7e-26, Method: Compositional matrix adjust. Identities = 89/296 (30%), Positives = 147/296 (49%), Gaps = 37/296 (12%) Query: 37 WKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEP--SDNGPLFTELKFYQRAAKP 93 ++VG IG G FG + L ++ ++E V +K+EP S L E +FY++ + Sbjct: 6 FRVGKKIGCGNFGELRLGKNLYTNEYVA------IKLEPIKSRAPQLHLEYRFYKQLSAT 59 Query: 94 EQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKT 153 E GVP+ + G K Y M+++ G L+ +++ + F+ KT Sbjct: 60 E--------------GVPQVYYFGPCGK----YNAMVLELLGPSLEDLFDLCDRTFTLKT 101 Query: 154 VLQLSLRILDILEYIHEHEYVHGDIKASNLLLN---YKNPDQVYLVDYGLAYRYC-PEGV 209 VL ++++++ +EY+H ++ D+K N L+ K ++++D+GLA Y PE Sbjct: 102 VLMIAIQLITRMEYVHTKSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETK 161 Query: 210 -HKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDP 268 H Y+E + GT + SI+ H G SRR DLE LG+ + +L G LPW+ D Sbjct: 162 KHIPYRE--HKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADT 219 Query: 269 KYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDIL 324 R KI + + C +N P E+A Y+ V+ LD+ EKP Y+ LR + Sbjct: 220 LKERYQKIGDTKRATPIEVLC---ENFPEEMATYLRYVRRLDFFEKPDYDYLRKLF 272 >1CSN-A nrPDB Length = 298 Score = 113 bits (283), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 92/321 (28%), Positives = 152/321 (47%), Gaps = 45/321 (14%) Query: 36 EWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQ 95 +KVG IG+G FG I+ ++ ++ +K EP R + Q Sbjct: 11 HYKVGRRIGEGSFGVIF-----EGTNLLNNQQVAIKFEP--------------RRSDAPQ 51 Query: 96 IQKWIRTRKL--KYLGVPK--YWGS-GLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFS 150 ++ RT KL G+P Y+G GLH+ +++D G L+ + + ++FS Sbjct: 52 LRDEYRTYKLLAGCTGIPNVYYFGQEGLHN-------VLVIDLLGPSLEDLLDLCGRKFS 104 Query: 151 RKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLL---NYKNPDQVYLVDYGLA--YRYC 205 KTV + ++L ++ IHE V+ DIK N L+ N KN + +Y+VD+G+ YR Sbjct: 105 VKTVAMAAKQMLARVQSIHEKSLVYRDIKPDNFLIGRPNSKNANMIYVVDFGMVKFYRDP 164 Query: 206 PEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNL 265 H Y+E K+ GT + SI+ H G SRR DLE LG+ + +L G LPW+ Sbjct: 165 VTKQHIPYRE--KKNLSGTARYMSINTHLGREQSRRDDLEALGHVFMYFLRGSLPWQGLK 222 Query: 266 KDPKYVRDSKIRYRENIASLMDKC--FPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDI 323 + +I ++ L + C FPE E KYM + L + P Y+ L+ + Sbjct: 223 AATNKQKYERIGEKKQSTPLRELCAGFPE-----EFYKYMHYARNLAFDATPDYDYLQGL 277 Query: 324 LLQGLKAIGSKDDGKLDLSVV 344 + L+ + + +D D +++ Sbjct: 278 FSKVLERLNTTEDENFDWNLL 298 >2CMW-A nrPDB Length = 310 Score = 113 bits (282), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 86/312 (27%), Positives = 147/312 (47%), Gaps = 38/312 (12%) Query: 38 KVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEP--SDNGPLFTELKFYQRAAKPEQ 95 +VG IG G FG ++ +++ ++ +K+EP S L E +FY++ + Sbjct: 3 RVGKKIGCGNFG-----ELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLGSAGE 57 Query: 96 IQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVL 155 G+P+ + G K Y M+++ G L+ +++ + F+ KTVL Sbjct: 58 -------------GLPQVYYFGPCGK----YNAMVLELLGPSLEDLFDLCDRTFTLKTVL 100 Query: 156 QLSLRILDILEYIHEHEYVHGDIKASNLLLNY---KNPDQVYLVDYGLAYRYCPEGVHKE 212 +++++L +EY+H ++ D+K N L+ K ++++D+GLA Y K Sbjct: 101 MIAIQLLSRMEYVHSKNLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKH 160 Query: 213 YKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWE----DNLKDP 268 + GT + SI+ H G SRR DLE LG+ + +L G LPW+ D LK+ Sbjct: 161 IPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKE- 219 Query: 269 KYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDILLQGL 328 +Y + + I +L + N P E+A Y+ V+ LD+ EKP YE LR + Sbjct: 220 RYQKIGDTKRNTPIEALCE------NFPEEMATYLRYVRRLDFFEKPDYEYLRTLFTDLF 273 Query: 329 KAIGSKDDGKLD 340 + G D D Sbjct: 274 EKKGYTFDYAYD 285 >2CHL-A nrPDB Length = 351 Score = 109 bits (272), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 86/305 (28%), Positives = 147/305 (48%), Gaps = 46/305 (15%) Query: 32 MAKKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEP--SDNGPLFTELKFYQ 88 M ++VG IG G FG + L ++ ++E V +K+EP S L E +FY+ Sbjct: 27 MVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVA------IKLEPMKSRAPQLHLEYRFYK 80 Query: 89 RAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKR 148 + + G+P+ + G K Y M+++ G L+ +++ + Sbjct: 81 QLGSGD--------------GIPQVYYFGPCGK----YNAMVLELLGPSLEDLFDLCDRT 122 Query: 149 FSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY---KNPDQVYLVDYGLAYRYC 205 FS KTVL ++++++ +EY+H ++ D+K N L+ K ++++D+ LA Y Sbjct: 123 FSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYI 182 Query: 206 PEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWE--- 262 K + GT + SI+ H G SRR DLE LG+ + +L G LPW+ Sbjct: 183 DPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLK 242 Query: 263 -DNLKDPKY--VRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYEN 319 D LK+ +Y + D+K R ++ + FP E+A Y+ V+ LD+ EKP Y+ Sbjct: 243 ADTLKE-RYQKIGDTK---RATPIEVLCENFP------EMATYLRYVRRLDFFEKPDYDY 292 Query: 320 LRDIL 324 LR + Sbjct: 293 LRKLF 297 >4XHL-A nrPDB Length = 394 Score = 108 bits (271), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 81/291 (27%), Positives = 139/291 (47%), Gaps = 39/291 (13%) Query: 35 KEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKP 93 +++++G IG G FG IY ++ S E V +++E + + Sbjct: 7 RKFRIGRKIGSGSFGDIYHGTNLISGEEVA------IRLE----------------SIRS 44 Query: 94 EQIQKWIRTRKLKYL----GVP--KYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAK 147 Q +R +YL G+P +++G + G+ Y M++D G L+ ++ + Sbjct: 45 RHPQLDYESRVYRYLSGGVGIPFIRWFG-----REGE-YNAMVIDLLGPSLEDLFNYCHR 98 Query: 148 RFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY-KNPDQVYLVDYGLAYRYCP 206 RFS KTV+ L+L++ ++YIH ++H DIK N L+ + V+++D+GL+ +Y Sbjct: 99 RFSFKTVIMLALQMFCRIQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRD 158 Query: 207 EGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLK 266 H+ + GT + S++ H G+ SRR DLE LGY +I + G LPW+ Sbjct: 159 FNTHRHIPYRENKSLTGTARYASVNTHLGIEQSRRDDLESLGYVLIYFCKGSLPWQGLKA 218 Query: 267 DPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLY 317 K + +I ++ S+ C P E +YM K L + EKP Y Sbjct: 219 TTKKQKYDRIMEKKLNVSVETLC---SGLPLEFQEYMAYCKNLKFDEKPDY 266 >4XHH-A nrPDB Length = 403 Score = 107 bits (267), Expect = 9e-24, Method: Compositional matrix adjust. Identities = 79/291 (27%), Positives = 141/291 (48%), Gaps = 39/291 (13%) Query: 35 KEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKP 93 +++++G IG G FG IY ++ S E V +++E + + Sbjct: 7 RKFRIGRKIGSGSFGDIYHGTNLISGEEVA------IRLE----------------SIRS 44 Query: 94 EQIQKWIRTRKLKYL----GVP--KYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAK 147 Q +R KYL G+P +++G + G+ Y M++D G L+ ++ + Sbjct: 45 RHPQLDYESRVYKYLSGGVGIPFIRWFG-----REGE-YNAMVIDLLGPSLEDLFNYCHR 98 Query: 148 RFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY-KNPDQVYLVDYGLAYRYCP 206 +FS KTV+ L+L+++ ++YIH ++H DIK N L+ + V+++D+GL+ +Y Sbjct: 99 KFSFKTVIMLALQMICRVQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRD 158 Query: 207 EGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLK 266 H+ + GT + S++ H G+ SRR DLE LGY +I + G LPW+ Sbjct: 159 FNTHRHIPYRENKSLTGTARYASVNTHLGIEQSRRDDLESLGYMLIYFCKGSLPWQGLKA 218 Query: 267 DPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLY 317 K + +I ++ S+ C P E ++YM + L + E+P Y Sbjct: 219 TTKKQKYDRILEKKLCISVETLC---AGLPLEFSEYMNYCRNLKFDERPDY 266 >4BTK-A nrPDB Length = 337 Score = 92.4 bits (228), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 88/321 (27%), Positives = 147/321 (45%), Gaps = 52/321 (16%) Query: 32 MAKKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRA 90 + K WKV IG GGFG IY A D+ + E+V +KVE A Sbjct: 53 VVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVA------LKVES---------------A 91 Query: 91 AKPEQIQKWIRTRKLKYL----GVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANA 146 +P+Q+ K + LK L V ++ G G ++K + +++M G +L + + Sbjct: 92 QQPKQVLK-MEVAVLKKLQGKDHVCRFIGCGRNEK----FNYVVMQLQGRNLADLRRSQP 146 Query: 147 K-RFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPD---QVYLVDYGLAY 202 + F+ T L+L +IL+ +E IH ++H DIK SN + + P + Y++D+GLA Sbjct: 147 RGTFTLSTTLRLGKQILESIEAIHSVGFLHRDIKPSNFAMG-RLPSTYRKCYMLDFGLAR 205 Query: 203 RYCPEGVHKEYKEDPKR---CHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHL 259 +Y + P R GT+ + S++AH R DL L Y ++++ G L Sbjct: 206 QY----TNTTGDVRPPRNVAGFRGTVRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQL 261 Query: 260 PWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYEN 319 PW +KD + V K +Y + K+ P E +++ + LDY KP Y+ Sbjct: 262 PWR-KIKDKEQVGMIKEKYEHRMLL--------KHMPSEFHLFLDHIASLDYFTKPDYQL 312 Query: 320 LRDILLQGLKAIGSKDDGKLD 340 + + +K G ++ D Sbjct: 313 IMSVFENSMKERGIAENEAFD 333 >4NFN-A nrPDB Length = 309 Score = 92.0 bits (227), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 88/321 (27%), Positives = 147/321 (45%), Gaps = 52/321 (16%) Query: 32 MAKKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRA 90 + K WKV IG GGFG IY A D+ + E+V +KVE A Sbjct: 18 VVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVA------LKVES---------------A 56 Query: 91 AKPEQIQKWIRTRKLKYL----GVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANA 146 +P+Q+ K + LK L V ++ G G ++K + +++M G +L + + Sbjct: 57 QQPKQVLK-MEVAVLKKLQGKDHVCRFIGCGRNEK----FNYVVMQLQGRNLADLRRSQP 111 Query: 147 K-RFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPD---QVYLVDYGLAY 202 + F+ T L+L +IL+ +E IH ++H DIK SN + + P + Y++D+GLA Sbjct: 112 RGTFTLSTTLRLGKQILESIEAIHSVGFLHRDIKPSNFAMG-RLPSTYRKCYMLDFGLAR 170 Query: 203 RYCPEGVHKEYKEDPKR---CHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHL 259 +Y + P R GT+ + S++AH R DL L Y ++++ G L Sbjct: 171 QYT----NTTGDVRPPRNVAGFRGTVRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQL 226 Query: 260 PWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYEN 319 PW +KD + V K +Y + K+ P E +++ + LDY KP Y+ Sbjct: 227 PWR-KIKDKEQVGMIKEKYEHRMLL--------KHMPSEFHLFLDHIASLDYFTKPDYQL 277 Query: 320 LRDILLQGLKAIGSKDDGKLD 340 + + +K G ++ D Sbjct: 278 IMSVFENSMKERGIAENEAFD 298 >4NST-A nrPDB Length = 351 Score = 54.3 bits (129), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 30/91 (32%), Positives = 47/91 (51%), Gaps = 2/91 (2%) Query: 117 GLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHG 176 L K K +++ + DL + E+ FS + ++++ LEY H+ ++H Sbjct: 87 ALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHR 146 Query: 177 DIKASNLLLNYKNPDQVYLVDYGLAYRYCPE 207 DIK SN+LLN N Q+ L D+GLA Y E Sbjct: 147 DIKCSNILLN--NSGQIKLADFGLARLYNSE 175 >4UZD-A nrPDB Length = 287 Score = 52.8 bits (125), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 58/250 (23%), Positives = 108/250 (43%), Gaps = 36/250 (14%) Query: 33 AKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAK 92 A +++++G P+G+G FG +YLA S+ + +KV LF ++A Sbjct: 6 ALEDFEIGRPLGKGKFGNVYLAREKQSKFI-----LALKV-------LFKAQ--LEKAGV 51 Query: 93 PEQIQKWIRTRK-LKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGS---DLQKIYEANAKR 148 Q+++ + + L++ + + +G HD + Y + G+ +LQK+ + Sbjct: 52 EHQLRREVEIQSHLRHPNILRLYGY-FHDAT-RVYLILEYAPLGTVYRELQKL-----SK 104 Query: 149 FSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEG 208 F + + + L Y H +H DIK NLLL + ++ + D+G + Sbjct: 105 FDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG--SAGELKIADFGWS------- 155 Query: 209 VHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDP 268 VH C GT+++ + G + DL LG ++L G P+E N Sbjct: 156 VHAPSSRRTTLC--GTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQE 213 Query: 269 KYVRDSKIRY 278 Y R S++ + Sbjct: 214 TYKRISRVEF 223 >5EFQ-A nrPDB Length = 347 Score = 52.0 bits (123), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 28/91 (30%), Positives = 47/91 (51%), Gaps = 2/91 (2%) Query: 117 GLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHG 176 L K K +++ + DL + E+ F+ + ++++ L+Y H+ ++H Sbjct: 85 ALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHR 144 Query: 177 DIKASNLLLNYKNPDQVYLVDYGLAYRYCPE 207 DIK SN+LLN N Q+ L D+GLA Y E Sbjct: 145 DIKCSNILLN--NRGQIKLADFGLARLYSSE 173 >3D2K-A nrPDB Length = 272 Score = 51.6 bits (122), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 61/256 (23%), Positives = 111/256 (43%), Gaps = 43/256 (16%) Query: 33 AKKEWK-----VGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLF-TELKF 86 +K++W +G P+G+G FG +YLA S+ + +KV LF T+L Sbjct: 5 SKRQWTLEDFDIGRPLGKGKFGNVYLARERQSKFI-----LALKV-------LFKTQL-- 50 Query: 87 YQRAAKPEQIQKWIRTRK-LKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGS---DLQKIY 142 ++A Q+++ + + L++ + + +G HD + Y + G+ +LQK+ Sbjct: 51 -EKAGVEHQLRREVEIQSHLRHPNILRLYGY-FHDAT-RVYLILEYAPLGTVYRELQKL- 106 Query: 143 EANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAY 202 RF + + + L Y H +H DIK NLLL + ++ + D+G + Sbjct: 107 ----SRFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG--SNGELKIADFGWS- 159 Query: 203 RYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWE 262 VH C GT+++ + G + DL LG ++L G P+E Sbjct: 160 ------VHAPSSRRTTLC--GTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGMPPFE 211 Query: 263 DNLKDPKYVRDSKIRY 278 + Y R S++ + Sbjct: 212 AHTYQETYRRISRVEF 227 >4I6B-A nrPDB Length = 308 Score = 48.9 bits (115), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 60/247 (24%), Positives = 106/247 (42%), Gaps = 32/247 (12%) Query: 25 VGEIITD-MAKKEWKVGLPIGQGGFG-CIYLADMNSSESVGSDAPCVVKVEPSDNGPLFT 82 + II D K + G +G+GGF C + D+ +++ + K+ P Sbjct: 17 ISRIIVDPTTGKRYSRGKTLGKGGFAKCYEMTDLTNNKVYAA------KIIP-------- 62 Query: 83 ELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIY 142 + R +KP Q +K + +L + K+ H K +++++ + S + Sbjct: 63 ----HSRVSKPHQREKIDKEIELHRILHHKHVVQFYHYFEDKENIYILLE-YCSRRSMAH 117 Query: 143 EANAKRFSRKTVLQLSLR-ILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 A++ + ++ LR I+ L+Y+HE E +H D+K N +N ++ + D+GLA Sbjct: 118 ILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFIN--ESMELKVGDFGLA 175 Query: 202 YRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPW 261 R P E +R GT + S + N D+ LG M L G P+ Sbjct: 176 ARLEP-------LEHRRRTICGTPNYLSPEVLNKQGHGAESDIWALGCVMYTMLLGRPPF 228 Query: 262 E-DNLKD 267 E NLK+ Sbjct: 229 ETTNLKE 235 >4Y83-A nrPDB Length = 332 Score = 48.5 bits (114), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 55/220 (25%), Positives = 93/220 (42%), Gaps = 37/220 (16%) Query: 43 IGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIR 101 I +G FG +YLA D+ + + + V + +PSD +IQ R Sbjct: 81 IPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSD-----------------VEIQACFR 123 Query: 102 TRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRI 161 + L WG +H FM GS L+K+ R ++ ++ + Sbjct: 124 HENIAELYGAVLWGETVH-------LFMEAGEGGSVLEKLESCGPMR--EFEIIWVTKHV 174 Query: 162 LDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCH 221 L L+++H + +H DIK SN++ + LVD+GL+ + E V+ + +D + Sbjct: 175 LKGLDFLHSKKVIHHDIKPSNIVFMST---KAVLVDFGLSVQMT-EDVY--FPKDLR--- 225 Query: 222 DGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPW 261 GT + S + S + D+ LG +I TG PW Sbjct: 226 -GTEIYMSPEVILCRGHSTKADIYSLGATLIHMQTGTPPW 264 >2GCD-A nrPDB Length = 309 Score = 48.1 bits (113), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 42/166 (25%), Positives = 68/166 (40%), Gaps = 23/166 (13%) Query: 43 IGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDN-GPLFTELKFYQRAAKPEQIQKWI 100 IG G FG +Y A D+ +SE V + ++ + E++F Q+ P IQ Sbjct: 23 IGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPNTIQ--- 79 Query: 101 RTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLR 160 Y G L + +++M+ + E + K + ++ Sbjct: 80 ------------YRGCYLREHTA----WLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHG 123 Query: 161 ILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCP 206 L L Y+H H +H D+KA N+LL+ P V L D+G A P Sbjct: 124 ALQGLAYLHSHNMIHRDVKAGNILLS--EPGLVKLGDFGSASIMAP 167 >1U5R-A nrPDB Length = 348 Score = 48.1 bits (113), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 42/166 (25%), Positives = 68/166 (40%), Gaps = 23/166 (13%) Query: 43 IGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDN-GPLFTELKFYQRAAKPEQIQKWI 100 IG G FG +Y A D+ +SE V + ++ + E++F Q+ P IQ Sbjct: 62 IGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPNTIQ--- 118 Query: 101 RTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLR 160 Y G L + +++M+ + E + K + ++ Sbjct: 119 ------------YRGCYLREHTA----WLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHG 162 Query: 161 ILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCP 206 L L Y+H H +H D+KA N+LL+ P V L D+G A P Sbjct: 163 ALQGLAYLHSHNMIHRDVKAGNILLS--EPGLVKLGDFGSASIMAP 206 >1KOB-A nrPDB Length = 387 Score = 47.8 bits (112), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 42/172 (24%), Positives = 74/172 (43%), Gaps = 12/172 (6%) Query: 117 GLHDKNGKSYRFMIMDRF--GSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYV 174 LHD Y +++ F G +L A + S V+ + + L+++HEH V Sbjct: 112 NLHDAFEDKYEMVLILEFLSGGELFDRIAAEDYKMSEAEVINYMRQACEGLKHMHEHSIV 171 Query: 175 HGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHN 234 H DIK N++ K V ++D+GLA + P+ + K T EF + + + Sbjct: 172 HLDIKPENIMCETKKASSVKIIDFGLATKLNPDEIVK--------VTTATAEFAAPEIVD 223 Query: 235 GVAPSRRGDLEILGYCMIQWLTGHLPW--EDNLKDPKYVRDSKIRYRENIAS 284 D+ +G L+G P+ ED+L+ + V+ + E+ S Sbjct: 224 REPVGFYTDMWAIGVLGYVLLSGLSPFAGEDDLETLQNVKRCDWEFDEDAFS 275 >5JN2-A nrPDB Length = 525 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 58/241 (24%), Positives = 96/241 (39%), Gaps = 53/241 (21%) Query: 2 PRVKAAQAGRQSSAKRHL-AEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSE 60 PR + AG HL A + T + +K +G+G FG + L + Sbjct: 33 PRSRGHAAGTSGGPGDHLHATPGMFVQHSTAIFSDRYKGQRVLGKGSFGEVILC---KDK 89 Query: 61 SVGSDAPCVVKV-------EPSDNGPLFTELKFYQRAAKPE--QIQKWIRTRKLKYLGVP 111 G + C VKV + +D L E++ ++ P ++ ++ + YL Sbjct: 90 ITGQE--CAVKVISKRQVKQKTDKESLLREVQLLKQLDHPNIMKLYEFFEDKGYFYLVGE 147 Query: 112 KYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEH 171 Y G L D+ I+ R KRFS ++ ++L + Y+H++ Sbjct: 148 VYTGGELFDE--------IISR-------------KRFSEVDAARIIRQVLSGITYMHKN 186 Query: 172 EYVHGDIKASNLLLNYKNPD-QVYLVDYGL----------------AYRYCPEGVHKEYK 214 + VH D+K NLLL K+ D + ++D+GL AY PE +H Y Sbjct: 187 KIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVLHGTYD 246 Query: 215 E 215 E Sbjct: 247 E 247 >5UV4-A nrPDB Length = 311 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 41/156 (26%), Positives = 68/156 (43%), Gaps = 17/156 (10%) Query: 113 YWGSGLHDKNGKSYRFMIMD-----RFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEY 167 YWG H+ R MI D + L + E N S L +++ I L+Y Sbjct: 90 YWGPKEHE------RIMISDYADATSLSTYLSEFDERNLPPLSAGQRLNIAIDIARCLDY 143 Query: 168 IHEHEYV-HGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIE 226 +H + HG+IK+SN+L+ P + + DY L P G+ ++ + E Sbjct: 144 LHNERVIPHGNIKSSNVLIQNSTPSAL-VTDYSLHRLMTPIGMAEQVLNAGALGYSPP-E 201 Query: 227 FTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWE 262 F+S + PS + D+ G +++ LTG + E Sbjct: 202 FSST---SKPCPSLKSDVYAFGVILLELLTGKIAGE 234 >4YNZ-A nrPDB Length = 342 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 35/148 (23%), Positives = 65/148 (43%), Gaps = 10/148 (6%) Query: 118 LHDK-NGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHG 176 LHD K Y +++++ Y R + K + +I+ L++ H H H Sbjct: 74 LHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHR 133 Query: 177 DIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGV 236 D+K NLLL+ +N + + D+G+A + + + P H E + ++G Sbjct: 134 DLKPENLLLDERN--NIRIADFGMASLQVGDSLLETSCGSP---HYACPEVIRGEKYDG- 187 Query: 237 APSRRGDLEILGYCMIQWLTGHLPWEDN 264 R+ D+ G + L G LP++D+ Sbjct: 188 ---RKADVWSCGVILFALLVGALPFDDD 212 >5XZW-A nrPDB Length = 471 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 43/167 (25%), Positives = 72/167 (43%), Gaps = 23/167 (13%) Query: 128 FMIMDRF-GSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLN 186 +M+M+ G DL A+ ++S +IL ++YIH H D+K N+L+ Sbjct: 270 YMVMEFVSGGDLMDFVAAHGA-VGEDAGREISRQILTAIKYIHSMGISHRDLKPDNILIE 328 Query: 187 YKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNG----VAP---- 238 +P V + D+GLA K + C GT+ + + + G V+P Sbjct: 329 QDDPVLVKITDFGLAKVQGNGSFMKTF------C--GTLAYVAPEVIRGKDTSVSPDEYE 380 Query: 239 -----SRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRYRE 280 S D+ +G + LTGHLP+ + +D Y + + Y E Sbjct: 381 ERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRGSYHE 427 >4B8L-A nrPDB Length = 286 Score = 45.4 bits (106), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 53/230 (23%), Positives = 98/230 (42%), Gaps = 34/230 (14%) Query: 36 EWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQ 95 ++ +G P+G+G FG +YLA ++ + +KV LF ++ Q Sbjct: 16 DFDIGRPLGKGKFGNVYLAREKQNKFI-----MALKV-------LFKSQ--LEKEGVEHQ 61 Query: 96 IQKWIRTRK-LKYLGVPKYWGSGLHDKNGKSYRFMIMDRFG--SDLQKIYEANAKRFSRK 152 +++ I + L++ + + + HD+ R +M F +L K + + RF + Sbjct: 62 LRREIEIQSHLRHPNILRMYNY-FHDRK----RIYLMLEFAPRGELYKELQKHG-RFDEQ 115 Query: 153 TVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKE 212 + D L Y HE + +H DIK NLL+ YK ++ + D+G + VH Sbjct: 116 RSATFMEELADALHYCHERKVIHRDIKPENLLMGYKG--ELKIADFGWS-------VHAP 166 Query: 213 YKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWE 262 C GT+++ + G + DL G ++L G P++ Sbjct: 167 SLRRRTMC--GTLDYLPPEMIEGKTHDEKVDLWCAGVLCYEFLVGMPPFD 214 >1UA2-A nrPDB Length = 346 Score = 45.1 bits (105), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 30/89 (33%), Positives = 47/89 (52%), Gaps = 3/89 (3%) Query: 117 GLHDKNG-KSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVH 175 GL D G KS ++ D +DL+ I + N+ + + L L LEY+H+H +H Sbjct: 76 GLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILH 135 Query: 176 GDIKASNLLLNYKNPDQVYLVDYGLAYRY 204 D+K +NLLL+ + L D+GLA + Sbjct: 136 RDLKPNNLLLDENG--VLKLADFGLAKSF 162 >3MA6-A nrPDB Length = 298 Score = 44.7 bits (104), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 51/209 (24%), Positives = 85/209 (40%), Gaps = 52/209 (24%) Query: 43 IGQGGFGCIYLADMNSSESVGSDAPCVVKV-------EPSDNGPLFTELKFYQRAAKPE- 94 +G+G FG + L + G + C VKV + +D L E++ ++ P Sbjct: 40 LGKGSFGEVILC---KDKITGQE--CAVKVISKRQVKQKTDKESLLREVQLLKQLDHPNI 94 Query: 95 -QIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKT 153 ++ ++ + YL Y G L D+ I+ R KRFS Sbjct: 95 MKLYEFFEDKGYFYLVGEVYTGGELFDE--------IISR-------------KRFSEVD 133 Query: 154 VLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPD-QVYLVDYGL------------ 200 ++ ++L + Y+H+++ VH D+K NLLL K+ D + ++D+GL Sbjct: 134 AARIIRQVLSGITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKD 193 Query: 201 ----AYRYCPEGVHKEYKEDPKRCHDGTI 225 AY PE +H Y E G I Sbjct: 194 KIGTAYYIAPEVLHGTYDEKCDVWSTGVI 222 >5B2L-A nrPDB Length = 324 Score = 44.7 bits (104), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 35/143 (24%), Positives = 68/143 (47%), Gaps = 10/143 (6%) Query: 128 FMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHE-HEYVHGDIKASNLLLN 186 F+ M+ G+ +K+ + + + ++++ I+ L Y+ E H +H D+K SN+LL+ Sbjct: 92 FIAMELMGTSAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLD 151 Query: 187 YKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSR--RGDL 244 + Q+ L D+G++ R V + K C + ID + P R D+ Sbjct: 152 ERG--QIKLCDFGISGRL----VDSKAKTRSAGCA-AYMAPERIDPPDPTKPDYDIRADV 204 Query: 245 EILGYCMIQWLTGHLPWEDNLKD 267 LG +++ TG P+++ D Sbjct: 205 WSLGISLVELATGQFPYKNCKTD 227 >3DB8-A nrPDB Length = 317 Score = 44.3 bits (103), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 63/288 (21%), Positives = 113/288 (39%), Gaps = 47/288 (16%) Query: 4 VKAAQAGRQSSAKRHLAEQFAVGEIITDM-----AKKEWKVGLPIGQGGFG-CIYLADMN 57 + AA A + H+ + A + I D+ K + G +G+GGF C + DM+ Sbjct: 6 MSAAIAKPSAKPSAHVDPKSAPLKEIPDVLVDPRTMKRYMRGRFLGKGGFAKCYEITDMD 65 Query: 58 SSES-VGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGS 116 + E G P + ++P + TE+ ++ P + Sbjct: 66 TKEVFAGKVVPKSMLLKPHQKEKMSTEIAIHKSLDNPHVV-----------------GFH 108 Query: 117 GLHDKNGKSYRFMIMDRFGSDLQ------KIYEANAKRFSRKTVLQLSLRILDILEYIHE 170 G + + Y + + R S L+ + E A+ F R+T+ + +Y+H Sbjct: 109 GFFEDDDFVYVVLEICRRRSLLELHKRRKAVTEPEARYFMRQTIQGV--------QYLHN 160 Query: 171 HEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSI 230 + +H D+K NL LN + V + D+GLA + E+ + K+ GT + + Sbjct: 161 NRVIHRDLKLGNLFLN--DDMDVKIGDFGLATKI-------EFDGERKKDLCGTPNYIAP 211 Query: 231 DAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRY 278 + S D+ LG + L G P+E + Y+R K Y Sbjct: 212 EVLCKKGHSFEVDIWSLGCILYTLLVGKPPFETSCLKETYIRIKKNEY 259 >4YZB-A nrPDB Length = 491 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 29/96 (30%), Positives = 44/96 (45%), Gaps = 17/96 (17%) Query: 147 KRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPD-QVYLVDYGL----- 200 KRFS ++ ++L + Y+H+++ VH D+K NLLL K D + ++D+GL Sbjct: 125 KRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFE 184 Query: 201 -----------AYRYCPEGVHKEYKEDPKRCHDGTI 225 AY PE +H Y E G I Sbjct: 185 STKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVI 220 >4C0T-A nrPDB Length = 974 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 43/176 (24%), Positives = 81/176 (46%), Gaps = 18/176 (10%) Query: 100 IRTRKLKYLGVPKYWGSGLHDKNGK-SYRFMIMDRFGSDLQKIYEANA------KRFS-- 150 I+ +K+KY+ + K+ + L ++ G S F D+ Y +N KR++ Sbjct: 305 IKEKKVKYVNIEKHALNRLSNRLGVISLYFTFQDKDSLYFVLDYASNGELLTLIKRYNTL 364 Query: 151 -RKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGV 209 + +ILD ++Y+H++ +H D+K N+LL+ K ++ + D+G A E Sbjct: 365 NEECTRHFGAQILDAIKYMHDNGVIHRDLKPENILLDDKM--RIQITDFGTARLL--EKK 420 Query: 210 HKEYKEDP----KRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPW 261 + E +E P + GT E+ S + + GD+ G + Q + G P+ Sbjct: 421 NDESEEYPVDVRAKSFVGTAEYVSPELLENKYCGKPGDVWAFGCIIYQMIAGKPPF 476 >4QTB-A nrPDB Length = 380 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 42/171 (24%), Positives = 76/171 (44%), Gaps = 18/171 (10%) Query: 43 IGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRT 102 IG+G +G + ++ + V + K+ P F + QR + +IQ +R Sbjct: 49 IGEGAYGMV----SSAYDHVRKTRVAIKKISP------FEHQTYCQRTLR--EIQILLRF 96 Query: 103 RKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRIL 162 R +G+ + + Y ++ D +DL K+ ++ ++ S + +IL Sbjct: 97 RHENVIGIRDILRASTLEAMRDVY--IVQDLMETDLYKLLKS--QQLSNDHICYFLYQIL 152 Query: 163 DILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEY 213 L+YIH +H D+K SNLL+N + + D+GLA PE H + Sbjct: 153 RGLKYIHSANVLHRDLKPSNLLIN--TTCDLKICDFGLARIADPEHDHTGF 201 >3ORP-A nrPDB Length = 311 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 53/254 (20%), Positives = 102/254 (40%), Gaps = 37/254 (14%) Query: 10 GRQSSAKRHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPC 68 G + HL++++ +GEI+ G GG ++LA D+ V Sbjct: 1 GSHMTTPSHLSDRYELGEIL--------------GFGGMSEVHLARDLRDHRDVA----- 41 Query: 69 VVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRF 128 VKV +D L + FY R + Q L + + + +G + + Sbjct: 42 -VKVLRAD---LARDPSFYLRFRREAQ-----NAAALNHPAIVAVYDTGEAETPAGPLPY 92 Query: 129 MIMDRF-GSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY 187 ++M+ G L+ I + K +++ L + H++ +H D+K +N++++ Sbjct: 93 IVMEYVDGVTLRDIVHTEGP-MTPKRAIEVIADACQALNFSHQNGIIHRDVKPANIMISA 151 Query: 188 KNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEIL 247 N V ++D+G+A G GT ++ S + G + R D+ L Sbjct: 152 TN--AVKVMDFGIARAIADSGNSVTQTA----AVIGTAQYLSPEQARGDSVDARSDVYSL 205 Query: 248 GYCMIQWLTGHLPW 261 G + + LTG P+ Sbjct: 206 GCVLYEVLTGEPPF 219 >4PDS-A nrPDB Length = 347 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 42/167 (25%), Positives = 71/167 (42%), Gaps = 23/167 (13%) Query: 128 FMIMDRF-GSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLN 186 +M+M+ G DL A+ ++S +IL ++YIH H D+K N+L+ Sbjct: 105 YMVMEFVSGGDLMDFVAAHGA-VGEDAGREISRQILTAIKYIHSMGISHRDLKPDNILIE 163 Query: 187 YKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNG----VAP---- 238 +P V + +GLA K + C GT+ + + + G V+P Sbjct: 164 QDDPVLVKITAFGLAKVQGNGSFMKTF------C--GTLAYVAPEVIRGKDTSVSPDEYE 215 Query: 239 -----SRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRYRE 280 S D+ +G + LTGHLP+ + +D Y + + Y E Sbjct: 216 ERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRGSYHE 262 >2WTK-C nrPDB Length = 305 Score = 42.7 bits (99), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 39/146 (26%), Positives = 65/146 (44%), Gaps = 11/146 (7%) Query: 124 KSYRFMIMDRFGSDLQKIYEANA-KRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASN 182 K +M+M+ +Q++ ++ KRF +++D LEY+H VH DIK N Sbjct: 80 KQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGN 139 Query: 183 LLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGV--APSR 240 LLL ++ + G+A E +H +D R G+ F + NG+ Sbjct: 140 LLLTTGGTLKISAL--GVA-----EALHPFAADDTCRTSQGSPAFQPPEIANGLDTFSGF 192 Query: 241 RGDLEILGYCMIQWLTGHLPWE-DNL 265 + D+ G + TG P+E DN+ Sbjct: 193 KVDIWSAGVTLYNITTGLYPFEGDNI 218 >3COM-A nrPDB Length = 314 Score = 42.4 bits (98), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 41/163 (25%), Positives = 71/163 (43%), Gaps = 31/163 (19%) Query: 43 IGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRT 102 +G+G +G +Y A + + + V+ SD + E+ Q+ P Sbjct: 37 LGEGSYGSVYKAIHKETGQIVAIKQVPVE---SDLQEIIKEISIMQQCDSPH-------- 85 Query: 103 RKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFG----SDLQKIYEANAKRFSRKTVLQLS 158 V KY+GS + + +++M+ G SD+ ++ T+LQ + Sbjct: 86 -------VVKYYGSYFKNTD----LWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQST 134 Query: 159 LRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 L+ L EY+H +H DIKA N+LLN + L D+G+A Sbjct: 135 LKGL---EYLHFMRKIHRDIKAGNILLNTEG--HAKLADFGVA 172 >5LOH-A nrPDB Length = 341 Score = 42.4 bits (98), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 28/99 (28%), Positives = 48/99 (48%), Gaps = 3/99 (3%) Query: 165 LEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGT 224 L+Y+H H +H D+K N+L++ N + L D+GL+ ++ R GT Sbjct: 147 LDYLHRHGIIHRDLKPDNMLIS--NEGHIKLTDFGLSKVTLNRDINM-MDILTTRTFCGT 203 Query: 225 IEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWED 263 ++ + + G A D LG C+ ++LTG P+ D Sbjct: 204 PDYLAPELLLGRAHGPAVDWWALGVCLFEFLTGIPPFND 242 >1V0B-A nrPDB Length = 288 Score = 42.0 bits (97), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 36/162 (22%), Positives = 71/162 (43%), Gaps = 21/162 (12%) Query: 43 IGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRT 102 IG+G +G +Y A N E+ +++E D G I++ Sbjct: 10 IGEGTYGVVYKAQNNYGETFALKK---IRLEKEDEG------------IPSTTIREISIL 54 Query: 103 RKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRIL 162 ++LK+ + K + +H K ++ + DL+K+ + T L++L Sbjct: 55 KELKHSNIVKLYDV-IHTK---KRLVLVFEHLDQDLKKLLDVCEGGLESVTAKSFLLQLL 110 Query: 163 DILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRY 204 + + Y H+ +H D+K NLL+N + ++ + D+GLA + Sbjct: 111 NGIAYCHDRRVLHRDLKPQNLLINREG--ELKIADFGLARAF 150 >5J0A-A nrPDB Length = 300 Score = 41.6 bits (96), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 33/126 (26%), Positives = 69/126 (54%), Gaps = 9/126 (7%) Query: 138 LQKIYEANAKRFSRKTVLQLSLRILDILEYIH-EHEYVHGDIKASNLLLNYKNPDQVYLV 196 +++ Y+A+ F +L+++L + L+Y+H E + +HGDIK+SN+++ + + + + Sbjct: 106 IEERYKASQDPFPAAIILKVALNMARGLKYLHQEKKLLHGDIKSSNVVIK-GDFETIKIC 164 Query: 197 DYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDA--HNGVAPSRRGDLEILGYCMIQW 254 D G++ P + E DP+ C+ GT + +A NGV + + D+ G + + Sbjct: 165 DVGVSL---PLDENMEVT-DPEACYIGTEPWKPKEAVEENGVI-TDKADIFAFGLTLWEM 219 Query: 255 LTGHLP 260 +T +P Sbjct: 220 MTLSIP 225 >5VO2-A nrPDB Length = 300 Score = 41.6 bits (96), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 28/111 (25%), Positives = 54/111 (48%), Gaps = 12/111 (10%) Query: 154 VLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEY 213 ++ S+ I + Y+H H+ +H D+K+ N+L+ Y D V + D+G + KE Sbjct: 102 LVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYD--DVVKISDFGTS---------KEL 150 Query: 214 KE-DPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWED 263 + K GT+ + + + S + D+ G + + LTG +P++D Sbjct: 151 SDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKD 201 >1VZO-A nrPDB Length = 355 Score = 41.6 bits (96), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 50/225 (22%), Positives = 94/225 (41%), Gaps = 30/225 (13%) Query: 43 IGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRT 102 +G G +G ++L V K+ D G L+ +K ++A ++ + T Sbjct: 62 LGTGAYGKVFL---------------VRKISGHDTGKLYA-MKVLKKATIVQKAKTTEHT 105 Query: 103 RK----LKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLS 158 R L+++ + + + ++ +I+D + + +RF+ V Sbjct: 106 RTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYV 165 Query: 159 LRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPK 218 I+ LE++H+ ++ DIK N+LL+ V L D+GL+ + + + Y Sbjct: 166 GEIVLALEHLHKLGIIYRDIKLENILLDSNG--HVVLTDFGLSKEFVADETERAY----D 219 Query: 219 RCHDGTIEFTSIDAHNG--VAPSRRGDLEILGYCMIQWLTGHLPW 261 C GTIE+ + D G + D LG M + LTG P+ Sbjct: 220 FC--GTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPF 262 >3HZT-A nrPDB Length = 467 Score = 41.6 bits (96), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 42/160 (26%), Positives = 69/160 (43%), Gaps = 40/160 (25%) Query: 75 SDNGPLFTELKFYQRAAKPE--QIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMD 132 S++G L E+ ++ P ++ ++ ++ YL + Y G L D+ I+ Sbjct: 46 SNSGALLDEVAVLKQLDHPNIMKLYEFFEDKRNYYLVMEVYRGGELFDE--------IIL 97 Query: 133 RFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQ 192 R QK E +A + ++L Y+H+H VH D+K NLLL K+ D Sbjct: 98 R-----QKFSEVDAAVIMK--------QVLSGTTYLHKHNIVHRDLKPENLLLESKSRDA 144 Query: 193 -VYLVDYGL----------------AYRYCPEGVHKEYKE 215 + +VD+GL AY PE + K+Y E Sbjct: 145 LIKIVDFGLSAHFEVGGKMKERLGTAYYIAPEVLRKKYDE 184 >1KOA-A nrPDB Length = 491 Score = 41.6 bits (96), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 48/237 (20%), Positives = 92/237 (38%), Gaps = 31/237 (13%) Query: 27 EIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKF 86 EI D + + +G G FG ++ + + G++ + P + Sbjct: 43 EIKHDHVLDHYDIHEELGTGAFGVVHRV---TERATGNNFAAKFVMTPHE---------- 89 Query: 87 YQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF--GSDLQKIYEA 144 + E ++K I+T + L P LHD +++ F G +L + Sbjct: 90 ----SDKETVRKEIQT--MSVLRHPTL--VNLHDAFEDDNEMVMIYEFMSGGELFEKVAD 141 Query: 145 NAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRY 204 + S ++ ++ L ++HE+ YVH D+K N++ K +++ L+D+GL Sbjct: 142 EHNKMSEDEAVEYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHL 201 Query: 205 CPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPW 261 P+ K GT EF + + G D+ +G L+G P+ Sbjct: 202 DPKQSVK--------VTTGTAEFAAPEVAEGKPVGYYTDMWSVGVLSYILLSGLSPF 250 >3UTO-A nrPDB Length = 573 Score = 41.6 bits (96), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 34/146 (23%), Positives = 63/146 (43%), Gaps = 10/146 (6%) Query: 118 LHDKNGKSYRFMIMDRF--GSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVH 175 LHD +++ F G +L + + S ++ ++ L ++HE+ YVH Sbjct: 219 LHDAFEDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQVCKGLCHMHENNYVH 278 Query: 176 GDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNG 235 D+K N++ K +++ L+D+GL H + K+ K GT EF + + G Sbjct: 279 LDLKPENIMFTTKRSNELKLIDFGLT-------AHLDPKQSVK-VTTGTAEFAAPEVAEG 330 Query: 236 VAPSRRGDLEILGYCMIQWLTGHLPW 261 D+ +G L+G P+ Sbjct: 331 KPVGYYTDMWSVGVLSYILLSGLSPF 356 >2OU7-A nrPDB Length = 335 Score = 41.6 bits (96), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 58/243 (23%), Positives = 98/243 (40%), Gaps = 40/243 (16%) Query: 43 IGQGGFG-CIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIR 101 +G+GGF C ++D ++ E K+ P LK +QR +I Sbjct: 49 LGKGGFAKCFEISDADTKEVFAG------KIVPKS-----LLLKPHQREKMSMEISIH-- 95 Query: 102 TRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQ------KIYEANAKRFSRKTVL 155 R L + V + G + N + + + R S L+ + E A+ + R+ VL Sbjct: 96 -RSLAHQHVVGF--HGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVL 152 Query: 156 QLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKE 215 +Y+H + +H D+K NL LN +V + D+GLA + EY Sbjct: 153 GC--------QYLHRNRVIHRDLKLGNLFLNEDL--EVKIGDFGLATKV-------EYDG 195 Query: 216 DPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSK 275 + K+ GT + + + + S D+ +G M L G P+E + Y+R K Sbjct: 196 ERKKVLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKK 255 Query: 276 IRY 278 Y Sbjct: 256 NEY 258 >4J52-A nrPDB Length = 293 Score = 41.6 bits (96), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 58/243 (23%), Positives = 98/243 (40%), Gaps = 40/243 (16%) Query: 43 IGQGGFG-CIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIR 101 +G+GGF C ++D ++ E K+ P LK +QR +I Sbjct: 22 LGKGGFAKCFEISDADTKEVFAG------KIVPKS-----LLLKPHQREKMSMEISIH-- 68 Query: 102 TRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQ------KIYEANAKRFSRKTVL 155 R L + V + G + N + + + R S L+ + E A+ + R+ VL Sbjct: 69 -RSLAHQHVVGF--HGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVL 125 Query: 156 QLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKE 215 +Y+H + +H D+K NL LN +V + D+GLA + EY Sbjct: 126 GC--------QYLHRNRVIHRDLKLGNLFLN--EDLEVKIGDFGLATKV-------EYDG 168 Query: 216 DPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSK 275 + K+ GT + + + + S D+ +G M L G P+E + Y+R K Sbjct: 169 ERKKVLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKK 228 Query: 276 IRY 278 Y Sbjct: 229 NEY 231 >5L2Q-C nrPDB Length = 320 Score = 41.2 bits (95), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 38/157 (24%), Positives = 66/157 (42%), Gaps = 19/157 (12%) Query: 142 YEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 Y KR S + + + ++ ++E +H+ VH D+K N++LN K ++ + ++ L Sbjct: 143 YVIKEKRLSERETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLN-KRTHRITITNFCLG 201 Query: 202 YRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSR--RGDLEILGYCMIQWLTGHL 259 EG D + G+ + S D +G P R D+ LG + L G Sbjct: 202 KHLVSEG-------DLLKDQRGSPAYISPDVLSG-RPYRGKPSDMWALGVVLFTMLYGQF 253 Query: 260 PWEDN--------LKDPKYVRDSKIRYRENIASLMDK 288 P+ D+ +K +Y R EN L+ K Sbjct: 254 PFYDSIPQELFRKIKAAEYTIPEDGRVSENTVCLIRK 290 >3LIJ-A nrPDB Length = 494 Score = 41.2 bits (95), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 28/85 (32%), Positives = 39/85 (45%), Gaps = 17/85 (20%) Query: 160 RILDILEYIHEHEYVHGDIKASNLLLNYKNPDQ-VYLVDYGL----------------AY 202 ++L + Y+H+H VH D+K NLLL K D + +VD+GL AY Sbjct: 144 QVLSGVTYLHKHNIVHRDLKPENLLLESKEKDALIKIVDFGLSAVFENQKKMKERLGTAY 203 Query: 203 RYCPEGVHKEYKEDPKRCHDGTIEF 227 PE + K+Y E G I F Sbjct: 204 YIAPEVLRKKYDEKCDVWSIGVILF 228 >4JG6-A nrPDB Length = 355 Score = 41.2 bits (95), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 36/131 (27%), Positives = 55/131 (41%), Gaps = 25/131 (19%) Query: 147 KRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLL--NYKNPDQVYLVDYGLAYRY 204 K FS + + I +EY+H VH D+K SN+L NP+ + + D+G A + Sbjct: 124 KFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQL 183 Query: 205 CPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAP---SRRG-----DLEILGYCMIQWLT 256 R +G + T N VAP R+G D+ LG + LT Sbjct: 184 --------------RAENGLL-MTPCYTANFVAPEVLERQGYDAACDIWSLGVLLYTMLT 228 Query: 257 GHLPWEDNLKD 267 G+ P+ + D Sbjct: 229 GYTPFANGPDD 239 >4IC8-A nrPDB Length = 442 Score = 41.2 bits (95), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 23/86 (26%), Positives = 47/86 (54%), Gaps = 3/86 (3%) Query: 128 FMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY 187 ++++D SDL +I ++ + + + V ++L L+Y+H + +H D+K SNLL+N Sbjct: 136 YVVLDLMESDLHQIIHSS-QPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNE 194 Query: 188 KNPDQVYLVDYGLAYRYCPEGVHKEY 213 ++ + D+G+A C +Y Sbjct: 195 NC--ELKIGDFGMARGLCTSPAEHQY 218 >5J5T-A nrPDB Length = 370 Score = 41.2 bits (95), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 45/162 (27%), Positives = 73/162 (45%), Gaps = 28/162 (17%) Query: 43 IGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIR 101 IG G +G +Y A ++N+ E A V+K+EP ++ F ++ Q+ I Sbjct: 12 IGSGTYGDVYKARNVNTGELA---AIKVIKLEPGED---FAVVQ-----------QEIIM 54 Query: 102 TRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF--GSDLQKIYEANAKRFSRKTVLQLSL 159 + K+ + Y+GS L + + I F G LQ IY S + +S Sbjct: 55 MKDCKHPNIVAYFGSYL-----RRDKLWICMEFCGGGSLQDIYHVTGP-LSELQIAYVSR 108 Query: 160 RILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 L L Y+H +H DIK +N+LL + V L D+G++ Sbjct: 109 ETLQGLYYLHSKGKMHRDIKGANILLT--DNGHVKLADFGVS 148 >4IDT-A nrPDB Length = 356 Score = 41.2 bits (95), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 32/113 (28%), Positives = 49/113 (43%), Gaps = 11/113 (9%) Query: 160 RILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKR 219 + L+ LEY+H +HGD+KA N+LL+ + L D+G A P+G+ K+ Sbjct: 174 QALEGLEYLHSRRILHGDVKADNVLLS-SDGSHAALCDFGHAVCLQPDGLGKDLLT---- 228 Query: 220 CHDGTIEFTSIDAHNGVAPSRRGD--LEILGYC--MIQWLTGHLPWEDNLKDP 268 I T V R D +++ C M+ L G PW + P Sbjct: 229 --GDYIPGTETHMAPEVVLGRSCDAKVDVWSSCCMMLHMLNGCHPWTQFFRGP 279 >3ORZ-A nrPDB Length = 316 Score = 41.2 bits (95), Expect = 9e-04, Method: Compositional matrix adjust. Identities = 30/100 (30%), Positives = 45/100 (45%), Gaps = 8/100 (8%) Query: 161 ILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRC 220 I+ LEY+H +H D+K N+LLN + + D+G A PE K+ Sbjct: 146 IVSALEYLHGKGIIHRDLKPENILLN--EDMHIQITDFGTAKVLSPES-----KQARANS 198 Query: 221 HDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLP 260 GT ++ S + + + DL LG C+I L LP Sbjct: 199 FVGTAQYVSPELLTEKSACKSSDLWALG-CIIYQLVAGLP 237 >2HK5-A nrPDB Length = 270 Score = 41.2 bits (95), Expect = 9e-04, Method: Compositional matrix adjust. Identities = 36/166 (21%), Positives = 84/166 (50%), Gaps = 20/166 (12%) Query: 154 VLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEY 213 ++ S +I + + +I + Y+H D++A+N+L++ ++ D+GLA V ++ Sbjct: 113 LIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKI--ADFGLAR------VIEDN 164 Query: 214 KEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT-GHLPWEDNLKDPKYVR 272 + + I++T+ +A N + + + D+ G +++ +T G +P+ + +P+ +R Sbjct: 165 EYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPY-PGMSNPEVIR 223 Query: 273 DSKIRYR--------ENIASLMDKCFPEKNKPGEIAKYMETVKLLD 310 + YR E + ++M +C+ KN+P E + +LD Sbjct: 224 ALERGYRMPRPENCPEELYNIMMRCW--KNRPEERPTFEYIQSVLD 267 >4JXF-A nrPDB Length = 266 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 42/180 (23%), Positives = 83/180 (46%), Gaps = 27/180 (15%) Query: 24 AVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTE 83 +GE I D +KVG +G+G F +Y A ES+ + +K+ + Sbjct: 1 CIGEKIED-----FKVGNLLGKGSFAGVYRA-----ESIHTGLEVAIKM---------ID 41 Query: 84 LKFYQRAAKPEQIQKWIRTR-KLKYLGVPKYWGSGLHDKNGKSYRFMIMDR-FGSDLQKI 141 K +A +++Q ++ +LK+ + + + D N Y +++++ ++ + Sbjct: 42 KKAMYKAGMVQRVQNEVKIHCQLKHPSILELYNY-FEDSN---YVYLVLEMCHNGEMNRY 97 Query: 142 YEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 + K FS +I+ + Y+H H +H D+ SNLLL +N + + + D+GLA Sbjct: 98 LKNRVKPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLT-RNMN-IKIADFGLA 155 >3NCG-A nrPDB Length = 486 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 19/56 (33%), Positives = 33/56 (58%), Gaps = 1/56 (1%) Query: 147 KRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPD-QVYLVDYGLA 201 KRFS ++ ++ + Y+H+H VH D+K N+LL K D + ++D+GL+ Sbjct: 116 KRFSEHDAARIIKQVFSGITYMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLS 171 >4G3E-A nrPDB Length = 352 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 30/107 (28%), Positives = 47/107 (43%), Gaps = 3/107 (2%) Query: 162 LDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCH 221 L+ LEY+H +HGD+KA N+LL+ + + L D+G A P+G+ K Sbjct: 176 LEGLEYLHTRRILHGDVKADNVLLS-SDGSRAALCDFGHALCLQPDGLGKSLLTGDYI-- 232 Query: 222 DGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDP 268 GT + + G + D+ M+ L G PW + P Sbjct: 233 PGTETHMAPEVVMGKPCDAKVDIWSSCCMMLHMLNGCHPWTQYFRGP 279 >3IS5-A nrPDB Length = 285 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 23/70 (32%), Positives = 37/70 (52%), Gaps = 3/70 (4%) Query: 135 GSDLQKIYEANA--KRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQ 192 G L++I A A K S V +L ++++ L Y H VH D+K N+L +P Sbjct: 105 GELLERIVSAQARGKALSEGYVAELMKQMMNALAYFHSQHVVHKDLKPENILFQDTSPHS 164 Query: 193 -VYLVDYGLA 201 + ++D+GLA Sbjct: 165 PIKIIDFGLA 174 >3DFA-A nrPDB Length = 286 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 19/56 (33%), Positives = 33/56 (58%), Gaps = 1/56 (1%) Query: 147 KRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPD-QVYLVDYGLA 201 KRFS ++ ++ + Y+H+H VH D+K N+LL K D + ++D+GL+ Sbjct: 116 KRFSEHDAARIIKQVFSGITYMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLS 171 >3DXN-A nrPDB Length = 287 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 42/160 (26%), Positives = 69/160 (43%), Gaps = 40/160 (25%) Query: 75 SDNGPLFTELKFYQRAAKPE--QIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMD 132 S++G L E+ ++ P ++ ++ ++ YL + Y G L D+ I+ Sbjct: 63 SNSGALLDEVAVLKQLDHPNIMKLYEFFEDKRNYYLVMEVYRGGELFDE--------IIL 114 Query: 133 RFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQ 192 R QK E +A + ++L Y+H+H VH D+K NLLL K+ D Sbjct: 115 R-----QKFSEVDAAVIMK--------QVLSGTTYLHKHNIVHRDLKPENLLLESKSRDA 161 Query: 193 -VYLVDYGL----------------AYRYCPEGVHKEYKE 215 + +VD+GL AY PE + K+Y E Sbjct: 162 LIKIVDFGLSAHFEVGGKMKERLGTAYYIAPEVLRKKYDE 201 >4QMW-A nrPDB Length = 310 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 32/94 (34%), Positives = 50/94 (53%), Gaps = 11/94 (11%) Query: 110 VPKYWGSGLHDKNGKSYRFMIMDRFG--SDLQKIYEANAKRFSRKTVLQLSLRILDILEY 167 V KY+GS L D + ++IM+ G S L + T+L+ IL L+Y Sbjct: 89 VTKYYGSYLKD----TKLWIIMEYLGGGSALDLLEPGPLDETQIATILR---EILKGLDY 141 Query: 168 IHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 +H + +H DIKA+N+LL+ +V L D+G+A Sbjct: 142 LHSEKKIHRDIKAANVLLSEHG--EVKLADFGVA 173 >5NGU-A nrPDB Length = 381 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 40/171 (23%), Positives = 76/171 (44%), Gaps = 18/171 (10%) Query: 43 IGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRT 102 IG+G +G + ++ +++ + K+ P F + QR + +I+ +R Sbjct: 50 IGEGAYGMV----CSAYDNLNKVRVAIKKISP------FEHQTYCQRTLR--EIKILLRF 97 Query: 103 RKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRIL 162 R +G+ + ++ Y ++ D +DL K+ + + S + +IL Sbjct: 98 RHENIIGINDIIRAPTIEQMKDVY--IVQDLMETDLYKLLKT--QHLSNDHICYFLYQIL 153 Query: 163 DILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEY 213 L+YIH +H D+K SNLLLN + + D+GLA P+ H + Sbjct: 154 RGLKYIHSANVLHRDLKPSNLLLN--TTCDLKICDFGLARVADPDHDHTGF 202 >3FXW-A nrPDB Length = 336 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 24/83 (28%), Positives = 39/83 (46%), Gaps = 3/83 (3%) Query: 122 NGKSYRFMIMDRF--GSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIK 179 +GK +IM+ G +I E + F+ + ++ I ++++H H H D+K Sbjct: 96 HGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLHSHNIAHRDVK 155 Query: 180 ASNLLLNYKNPDQVY-LVDYGLA 201 NLL K D V L D+G A Sbjct: 156 PENLLYTSKEKDAVLKLTDFGFA 178 >4MYG-A nrPDB Length = 372 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 25/74 (33%), Positives = 41/74 (55%), Gaps = 5/74 (6%) Query: 128 FMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY 187 +++M +DLQKI FS + + L ++L L+YIH VH D+K NL +N Sbjct: 124 YLVMPFMQTDLQKIM---GMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVN- 179 Query: 188 KNPDQVYLVDYGLA 201 ++ ++D+GLA Sbjct: 180 -EDCELKILDFGLA 192 >2X4F-A nrPDB Length = 373 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 26/102 (25%), Positives = 50/102 (49%), Gaps = 8/102 (7%) Query: 160 RILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKR 219 +I + + ++H+ +H D+K N+L ++ Q+ ++D+GLA RY P + + Sbjct: 195 QICEGIRHMHQMYILHLDLKPENILCVNRDAKQIKIIDFGLARRYKP--------REKLK 246 Query: 220 CHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPW 261 + GT EF + + N S D+ +G L+G P+ Sbjct: 247 VNFGTPEFLAPEVVNYDFVSFPTDMWSVGVIAYMLLSGLSPF 288 >3Q5I-A nrPDB Length = 504 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 28/88 (31%), Positives = 40/88 (45%), Gaps = 17/88 (19%) Query: 145 NAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNP-DQVYLVDYGL--- 200 N +F + +IL + Y+H+H VH DIK N+LL KN + +VD+GL Sbjct: 139 NRHKFDECDAANIMKQILSGICYLHKHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSF 198 Query: 201 -------------AYRYCPEGVHKEYKE 215 AY PE + K+Y E Sbjct: 199 FSKDYKLRDRLGTAYYIAPEVLKKKYNE 226 >4ZSG-A nrPDB Length = 347 Score = 39.3 bits (90), Expect = 0.003, Method: Compositional matrix adjust. Identities = 23/86 (26%), Positives = 47/86 (54%), Gaps = 3/86 (3%) Query: 128 FMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY 187 ++++D SDL +I ++ + + + V ++L L+Y+H + +H D+K SNLL+N Sbjct: 88 YVVLDLMESDLHQIIHSS-QPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNE 146 Query: 188 KNPDQVYLVDYGLAYRYCPEGVHKEY 213 ++ + D+G+A C +Y Sbjct: 147 NC--ELKIGDFGMARGLCTSPAEHQY 170 >5HI2-A nrPDB Length = 283 Score = 39.3 bits (90), Expect = 0.003, Method: Compositional matrix adjust. Identities = 47/233 (20%), Positives = 90/233 (38%), Gaps = 46/233 (19%) Query: 39 VGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPL-----FTELKFYQRAAKP 93 VG IG G FG +Y + +V P ++ ++ G L L F + KP Sbjct: 24 VGQRIGSGSFGTVYKGKWHGDVAVKMLTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKP 83 Query: 94 EQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKT 153 + L + W GS L A+ +F K Sbjct: 84 Q-------------LAIVTQWCE------------------GSSLYHHLHASETKFEMKK 112 Query: 154 VLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEY 213 ++ ++ + ++Y+H +H D+K++N+ L+ N V + D+GLA ++ Sbjct: 113 LIDIARQTARGMDYLHAKSIIHRDLKSNNIFLHEDNT--VKIGDFGLATVKSRWSGSHQF 170 Query: 214 KEDPKRCHDGTIEFTS---IDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWED 263 ++ G+I + + I + S + D+ G + + +TG LP+ + Sbjct: 171 EQL-----SGSILWMAPEVIRMQDSNPYSFQSDVYAFGIVLYELMTGQLPYSN 218 >1S9I-A nrPDB Length = 354 Score = 39.3 bits (90), Expect = 0.003, Method: Compositional matrix adjust. Identities = 30/127 (23%), Positives = 60/127 (47%), Gaps = 13/127 (10%) Query: 135 GSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHE-HEYVHGDIKASNLLLNYKNPDQV 193 G L ++ + AKR + + ++S+ +L L Y+ E H+ +H D+K SN+L+N + ++ Sbjct: 98 GGSLDQVLK-EAKRIPEEILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRG--EI 154 Query: 194 YLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQ 253 L D+ GV + + GT + + + G S + D+ +G +++ Sbjct: 155 KLCDF---------GVSGQLIDSMANSFVGTRSYMAPERLQGTHYSVQSDIWSMGLSLVE 205 Query: 254 WLTGHLP 260 G P Sbjct: 206 LAVGRYP 212 >2Z7Q-A nrPDB Length = 321 Score = 38.9 bits (89), Expect = 0.003, Method: Compositional matrix adjust. Identities = 53/227 (23%), Positives = 98/227 (43%), Gaps = 38/227 (16%) Query: 43 IGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRT 102 +GQG FG ++L V KV D+G L+ +K ++A +++ +RT Sbjct: 36 LGQGSFGKVFL---------------VRKVTRPDSGHLYA-MKVLKKATL--KVRDRVRT 77 Query: 103 RKLKYL--GVPKYWGSGLH---DKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQL 157 + + + V + LH GK Y + R G ++ + F+ + V Sbjct: 78 KMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRL--SKEVMFTEEDVKFY 135 Query: 158 SLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDP 217 + L+++H ++ D+K N+LL+ + + L D+GL+ KE + Sbjct: 136 LAELALGLDHLHSLGIIYRDLKPENILLDEEG--HIKLTDFGLS---------KEAIDHE 184 Query: 218 KRCHD--GTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWE 262 K+ + GT+E+ + + N S D G M + LTG LP++ Sbjct: 185 KKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQ 231 >2BRG-A nrPDB Length = 297 Score = 38.9 bits (89), Expect = 0.004, Method: Compositional matrix adjust. Identities = 66/249 (26%), Positives = 105/249 (42%), Gaps = 67/249 (26%) Query: 35 KEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAK-P 93 ++W + +G+G +G + LA +E V V+ D +RA P Sbjct: 7 EDWDLVQTLGEGAYGEVQLAVNRVTEEA-------VAVKIVD----------MKRAVDCP 49 Query: 94 EQIQKWIRTRK-LKYLGVPKYWGSGLHDKNGK-SYRFM-------IMDRFGSDLQKIYEA 144 E I+K I K L + V K++G H + G Y F+ + DR D+ + E Sbjct: 50 ENIKKEICINKMLNHENVVKFYG---HRREGNIQYLFLEYCSGGELFDRIEPDI-GMPEP 105 Query: 145 NAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA--Y 202 +A+RF + ++ + Y+H H DIK NLLL+ + D + + D+GLA + Sbjct: 106 DAQRFFHQ--------LMAGVVYLHGIGITHRDIKPENLLLDER--DNLKISDFGLATVF 155 Query: 203 RYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPS---RRG------DLEILGYCMIQ 253 RY + + K C GT+ + VAP RR D+ G + Sbjct: 156 RY-----NNRERLLNKMC--GTLPY--------VAPELLKRREFHAEPVDVWSCGIVLTA 200 Query: 254 WLTGHLPWE 262 L G LPW+ Sbjct: 201 MLAGELPWD 209 >5D9K-A nrPDB Length = 330 Score = 38.9 bits (89), Expect = 0.004, Method: Compositional matrix adjust. Identities = 26/100 (26%), Positives = 50/100 (50%), Gaps = 13/100 (13%) Query: 165 LEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHD-- 222 L+++H ++ D+K N+LL+ + + L D+GL+ KE + K+ + Sbjct: 145 LDHLHSLGIIYRDLKPENILLDEEG--HIKLTDFGLS---------KESIDHEKKAYSFC 193 Query: 223 GTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWE 262 GT+E+ + + N ++ D G M + LTG LP++ Sbjct: 194 GTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQ 233 >2J90-A nrPDB Length = 304 Score = 38.9 bits (89), Expect = 0.004, Method: Compositional matrix adjust. Identities = 34/140 (24%), Positives = 57/140 (40%), Gaps = 12/140 (8%) Query: 142 YEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLL---NYKNPDQVYLVDY 198 + A + + Q +ILD + Y+H H D+K N++L N NP ++ L+D+ Sbjct: 119 FLAEKESLTEDEATQFLKQILDGVHYLHSKRIAHFDLKPENIMLLDKNVPNP-RIKLIDF 177 Query: 199 GLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGH 258 G+A HK + + GT EF + + N D+ +G L+G Sbjct: 178 GIA--------HKIEAGNEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGA 229 Query: 259 LPWEDNLKDPKYVRDSKIRY 278 P+ K S + Y Sbjct: 230 SPFLGETKQETLTNISAVNY 249 >4L42-A nrPDB Length = 346 Score = 38.9 bits (89), Expect = 0.004, Method: Compositional matrix adjust. Identities = 30/99 (30%), Positives = 47/99 (47%), Gaps = 13/99 (13%) Query: 165 LEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHD-- 222 L ++H+ ++ D+K N++LN++ V L D+GL C E +H D H Sbjct: 135 LGHLHQKGIIYRDLKPENIMLNHQG--HVKLTDFGL----CKESIH-----DGTVTHTFC 183 Query: 223 GTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPW 261 GTIE+ + + +R D LG M LTG P+ Sbjct: 184 GTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPF 222 >4FZF-B nrPDB Length = 283 Score = 38.9 bits (89), Expect = 0.004, Method: Compositional matrix adjust. Identities = 42/154 (27%), Positives = 66/154 (42%), Gaps = 14/154 (9%) Query: 110 VPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIH 169 V KY+GS L K K + M GS L + F T+L+ IL L+Y+H Sbjct: 68 VTKYYGSYL--KGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLK---EILKGLDYLH 122 Query: 170 EHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTS 229 + +H DIKA+N+LL+ + V L +G+A + + + GT + + Sbjct: 123 SEKKIHRDIKAANVLLSEQG--DVKLAAFGVAGQLTDTQIK-------RNTFVGTPFWMA 173 Query: 230 IDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWED 263 + A + D+ LG I+ G P D Sbjct: 174 PEVIQQSAYDSKADIWSLGITAIELAKGEPPNSD 207 >1G3N-A nrPDB Length = 326 Score = 38.9 bits (89), Expect = 0.004, Method: Compositional matrix adjust. Identities = 18/53 (33%), Positives = 31/53 (58%), Gaps = 2/53 (3%) Query: 152 KTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRY 204 +T+ + ++L L+++H H VH D+K N+L+ Q+ L D+GLA Y Sbjct: 120 ETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSG--QIKLADFGLARIY 170 >3AOX-A nrPDB Length = 344 Score = 38.5 bits (88), Expect = 0.005, Method: Compositional matrix adjust. Identities = 26/87 (29%), Positives = 44/87 (50%), Gaps = 16/87 (18%) Query: 127 RFMIMDRF-GSDLQKIYEANAKRFSRKTVLQLSLRILDIL----------EYIHEHEYVH 175 RF++++ G DL+ R S+ + SL +LD+L +Y+ E+ ++H Sbjct: 125 RFILLELMAGGDLKSFLRETRPRPSQPS----SLAMLDLLHVARDIACGCQYLEENHFIH 180 Query: 176 GDIKASNLLLNYKNPDQVYLV-DYGLA 201 DI A N LL P +V + D+G+A Sbjct: 181 RDIAARNCLLTCPGPGRVAKIGDFGMA 207 >6DBN-A nrPDB Length = 316 Score = 38.5 bits (88), Expect = 0.005, Method: Compositional matrix adjust. Identities = 38/160 (23%), Positives = 76/160 (47%), Gaps = 16/160 (10%) Query: 43 IGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRT 102 +G+G FG + L + + V ++P G +LK ++I+ Sbjct: 43 LGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLK--------KEIEIL--- 91 Query: 103 RKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGS-DLQKIYEANAKRFSRKTVLQLSLRI 161 R L + + KY G+ ++G + +IM+ S L++ N + + K L+ +++I Sbjct: 92 RNLYHENIVKY--KGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQI 149 Query: 162 LDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 ++Y+ +YVH D+ A N+L+ ++ QV + D+GL Sbjct: 150 CKGMDYLGSRQYVHRDLAARNVLVESEH--QVKIGDFGLT 187 >1AD5-A nrPDB Length = 438 Score = 38.5 bits (88), Expect = 0.005, Method: Compositional matrix adjust. Identities = 35/166 (21%), Positives = 80/166 (48%), Gaps = 30/166 (18%) Query: 154 VLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEY 213 ++ S +I + + +I + Y+H D++A+N+L++ ++ D+GLA Sbjct: 280 LIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKI--ADFGLA------------ 325 Query: 214 KEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT-GHLPWEDNLKDPKYVR 272 + I++T+ +A N + + + D+ G +++ +T G +P+ + +P+ +R Sbjct: 326 ----RVGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYP-GMSNPEVIR 380 Query: 273 DSKIRYR--------ENIASLMDKCFPEKNKPGEIAKYMETVKLLD 310 + YR E + ++M +C+ KN+P E + +LD Sbjct: 381 ALERGYRMPRPENCPEELYNIMMRCW--KNRPEERPTFEYIQSVLD 424 >3BBT-B nrPDB Length = 328 Score = 38.5 bits (88), Expect = 0.005, Method: Compositional matrix adjust. Identities = 41/174 (23%), Positives = 71/174 (40%), Gaps = 19/174 (10%) Query: 43 IGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRT 102 +G G FG +Y + E P +K+ GP A E + + + Sbjct: 23 LGSGAFGTVY-KGIWVPEGETVKIPVAIKILNETTGP----------KANVEFMDEALIM 71 Query: 103 RKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRIL 162 + + + + G L + M G L+ ++E + + +L ++I Sbjct: 72 ASMDHPHLVRLLGVCLSPTIQLVTQLM---PHGCLLEYVHE-HKDNIGSQLLLNWCVQIA 127 Query: 163 DILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKED 216 + Y+ E VH D+ A N+L+ K+P+ V + D+GLA EG KEY D Sbjct: 128 KGMMYLEERRLVHRDLAARNVLV--KSPNHVKITDFGLARLL--EGDEKEYNAD 177 >1FOT-A nrPDB Length = 318 Score = 38.5 bits (88), Expect = 0.005, Method: Compositional matrix adjust. Identities = 38/169 (22%), Positives = 81/169 (47%), Gaps = 20/169 (11%) Query: 128 FMIMDRF-GSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLN 186 FMIMD G +L + ++RF + + LEY+H + ++ D+K N+LL+ Sbjct: 82 FMIMDYIEGGELFSLLR-KSQRFPNPVAKFYAAEVCLALEYLHSKDIIYRDLKPENILLD 140 Query: 187 YKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEI 246 KN + + D+G A +Y P+ + C GT ++ + + + ++ D Sbjct: 141 -KN-GHIKITDFGFA-KYVPDVTY-------TLC--GTPDYIAPEVVSTKPYNKSIDWWS 188 Query: 247 LGYCMIQWLTGHLPWEDN--LKDPKYVRDSKIR----YRENIASLMDKC 289 G + + L G+ P+ D+ +K + + ++++R + E++ L+ + Sbjct: 189 FGILIYEMLAGYTPFYDSNTMKTYEKILNAELRFPPFFNEDVKDLLSRL 237 >2JDO-A nrPDB Length = 342 Score = 38.5 bits (88), Expect = 0.006, Method: Compositional matrix adjust. Identities = 29/101 (28%), Positives = 46/101 (45%), Gaps = 9/101 (8%) Query: 161 ILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRC 220 I+ LEY+H + V+ DIK NL+L+ + + D+GL C EG+ + Sbjct: 119 IVSALEYLHSRDVVYRDIKLENLMLD--KDGHIKITDFGL----CKEGISDGAT---MKT 169 Query: 221 HDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPW 261 GT E+ + + R D LG M + + G LP+ Sbjct: 170 FCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPF 210 >2PL0-A nrPDB Length = 289 Score = 38.5 bits (88), Expect = 0.006, Method: Compositional matrix adjust. Identities = 36/184 (19%), Positives = 88/184 (47%), Gaps = 24/184 (13%) Query: 135 GSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVY 194 GS + + + + + +L ++ +I + + +I E Y+H D++A+N+L++ + Sbjct: 102 GSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVS--DTLSCK 159 Query: 195 LVDYGLAYRYCPEGVHKEYKEDPKRCHDGT---IEFTSIDAHNGVAPSRRGDLEILGYCM 251 + D+GLA + +++ +G I++T+ +A N + + D+ G + Sbjct: 160 IADFGLA---------RLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILL 210 Query: 252 IQWLT-GHLPWEDNLKDPKYVRDSKIRYR--------ENIASLMDKCFPEKNKPGEIAKY 302 + +T G +P+ + +P+ +++ + YR E + LM C+ E+ + Y Sbjct: 211 TEIVTHGRIPY-PGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDY 269 Query: 303 METV 306 + +V Sbjct: 270 LRSV 273 >3GC9-A nrPDB Length = 370 Score = 38.5 bits (88), Expect = 0.006, Method: Compositional matrix adjust. Identities = 23/74 (31%), Positives = 42/74 (56%), Gaps = 4/74 (5%) Query: 128 FMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY 187 +++ G+DL I ++ A S + V L ++L L+YIH +H D+K SN+ +N Sbjct: 109 YLVTTLMGADLNNIVKSQA--LSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVN- 165 Query: 188 KNPDQVYLVDYGLA 201 ++ ++D+GLA Sbjct: 166 -EDSELRILDFGLA 178 >3KN6-A nrPDB Length = 325 Score = 38.1 bits (87), Expect = 0.006, Method: Compositional matrix adjust. Identities = 30/142 (21%), Positives = 64/142 (45%), Gaps = 12/142 (8%) Query: 126 YRFMIMDRF--GSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNL 183 + F++M+ G ++I K FS + +++ + ++H+ VH D+K NL Sbjct: 80 HTFLVMELLNGGELFERI--KKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLKPENL 137 Query: 184 LLNYKNPD-QVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRG 242 L +N + ++ ++D+G A P+ P + T+ + + + N Sbjct: 138 LFTDENDNLEIKIIDFGFARLKPPDN-------QPLKTPCFTLHYAAPELLNQNGYDESC 190 Query: 243 DLEILGYCMIQWLTGHLPWEDN 264 DL LG + L+G +P++ + Sbjct: 191 DLWSLGVILYTMLSGQVPFQSH 212 >4EQM-A nrPDB Length = 294 Score = 38.1 bits (87), Expect = 0.006, Method: Compositional matrix adjust. Identities = 31/136 (22%), Positives = 64/136 (47%), Gaps = 12/136 (8%) Query: 128 FMIMDRF-GSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLN 186 +++M+ G L + E++ S T + + +ILD +++ H+ VH DIK N+L++ Sbjct: 87 YLVMEYIEGPTLSEYIESHGP-LSVDTAINFTNQILDGIKHAHDMRIVHRDIKPQNILID 145 Query: 187 YKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHD-GTIEFTSIDAHNGVAPSRRGDLE 245 +++ D+G+A + + H GT+++ S + G A D+ Sbjct: 146 SNKTLKIF--DFGIAKALSETSL-------TQTNHVLGTVQYFSPEQAKGEATDECTDIY 196 Query: 246 ILGYCMIQWLTGHLPW 261 +G + + L G P+ Sbjct: 197 SIGIVLYEMLVGEPPF 212 >3OHT-A nrPDB Length = 389 Score = 38.1 bits (87), Expect = 0.006, Method: Compositional matrix adjust. Identities = 23/74 (31%), Positives = 41/74 (55%), Gaps = 4/74 (5%) Query: 128 FMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY 187 +++ G+DL I ++ + V L +IL L+YIH + +H D+K SNL +N Sbjct: 132 YLVTHLMGADLNNI--VKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNE 189 Query: 188 KNPDQVYLVDYGLA 201 ++ ++D+GLA Sbjct: 190 DC--ELKILDFGLA 201 >4MVF-A nrPDB Length = 506 Score = 38.1 bits (87), Expect = 0.006, Method: Compositional matrix adjust. Identities = 55/230 (23%), Positives = 92/230 (40%), Gaps = 50/230 (21%) Query: 43 IGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRT 102 +GQG +GC+Y + + + +K E D LK R + +I K Sbjct: 65 LGQGTYGCVYKGIDKVTNQLYA-----IKEEKKD------RLKNINRFFQEIEIMK---- 109 Query: 103 RKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYEANAKRFSRKTVLQLSLRI 161 KL + + K + + +D +Y ++IM+ G +L N F+ K + +I Sbjct: 110 -KLDHPNIVKLYETYEND----NYIYLIMELCSGRELFDSIIENG-SFTEKNAATIMKQI 163 Query: 162 LDILEYIHEHEYVHGDIKASNLLLNYKNPDQVY-LVDYGLAYRYCPEGVHKEYKEDPKRC 220 + Y+H VH D+K N L +N D + ++D+GL+ Sbjct: 164 FSAIFYLHSLNIVHRDLKPENFLFQSENKDSLLKIIDFGLSKNL---------------- 207 Query: 221 HDGTIEFTSIDAHNG--VAP-------SRRGDLEILGYCMIQWLTGHLPW 261 GT EFT+ A VAP ++ D+ G M L G+ P+ Sbjct: 208 --GTGEFTTTKAGTPYYVAPQVLDGKYDKKCDIWSSGVIMYTLLCGYPPF 255 >4RGJ-A nrPDB Length = 520 Score = 38.1 bits (87), Expect = 0.006, Method: Compositional matrix adjust. Identities = 25/87 (28%), Positives = 41/87 (47%), Gaps = 18/87 (20%) Query: 147 KRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQ--VYLVDYGL---- 200 KRF ++ +IL + Y+H++ VH D+K N+LL KN + + ++D+GL Sbjct: 155 KRFYEIDAARIIKQILSGITYMHKNNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHF 214 Query: 201 ------------AYRYCPEGVHKEYKE 215 AY P+ +H Y E Sbjct: 215 EYSKKMKDKIGTAYYIAPDVLHGTYDE 241 >6CQF-A nrPDB Length = 297 Score = 38.1 bits (87), Expect = 0.007, Method: Compositional matrix adjust. Identities = 40/161 (24%), Positives = 72/161 (44%), Gaps = 26/161 (16%) Query: 43 IGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIR 101 +G G +G ++ A D S + V A +VK+EP D+ + + + I + Sbjct: 24 LGGGTYGEVFKARDKVSGDLV---ALKMVKMEPDDDVSTLQKEILILKTCRHANIVAYHG 80 Query: 102 TRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGS-DLQKIYEANAKRFSRKTVLQLSLR 160 + YL + K W + M+ G+ LQ IY+ S + + Sbjct: 81 S----YLWLQKLW--------------ICMEFCGAGSLQDIYQVTGS-LSELQISYVCRE 121 Query: 161 ILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 +L L Y+H + +H DIK +N+L+N + +V L D+G++ Sbjct: 122 VLQGLAYLHSQKKIHRDIKGANILIN--DAGEVRLADFGIS 160 >3Q53-A nrPDB Length = 306 Score = 38.1 bits (87), Expect = 0.007, Method: Compositional matrix adjust. Identities = 26/100 (26%), Positives = 45/100 (45%), Gaps = 9/100 (9%) Query: 162 LDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCH 221 L LE++H ++ +H DIK+ N+LL V L D+G + PE + + Sbjct: 127 LQALEFLHSNQVIHRDIKSDNILLGMDG--SVKLTDFGFCAQITPE-------QSKRSTM 177 Query: 222 DGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPW 261 GT + + + A + D+ LG I+ + G P+ Sbjct: 178 VGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPY 217 >4RLP-A nrPDB Length = 288 Score = 38.1 bits (87), Expect = 0.007, Method: Compositional matrix adjust. Identities = 30/99 (30%), Positives = 47/99 (47%), Gaps = 13/99 (13%) Query: 165 LEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHD-- 222 L ++H+ ++ D+K N++LN++ V L D+GL C E +H D H Sbjct: 122 LGHLHQKGIIYRDLKPENIMLNHQG--HVKLTDFGL----CKESIH-----DGTVTHTFC 170 Query: 223 GTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPW 261 GTIE+ + + +R D LG M LTG P+ Sbjct: 171 GTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPF 209 >5Y86-A nrPDB Length = 588 Score = 37.7 bits (86), Expect = 0.008, Method: Compositional matrix adjust. Identities = 19/77 (24%), Positives = 42/77 (54%), Gaps = 1/77 (1%) Query: 124 KSYRFMIMDRFGSDLQKIYEANA-KRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASN 182 +++ M + DL ++ + N + FS + V + + IL L+ +H+++ +H D+K N Sbjct: 281 RNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPEN 340 Query: 183 LLLNYKNPDQVYLVDYG 199 +LL + ++D+G Sbjct: 341 ILLKHHGRSSTKVIDFG 357 >2V7O-A nrPDB Length = 336 Score = 37.7 bits (86), Expect = 0.008, Method: Compositional matrix adjust. Identities = 20/43 (46%), Positives = 28/43 (65%), Gaps = 1/43 (2%) Query: 160 RILDILEYIHEHEYVHGDIKASNLLLNYK-NPDQVYLVDYGLA 201 +IL+ + +IH+H+ VH D+K NLLL K V L D+GLA Sbjct: 138 QILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLA 180 >5KKR-C nrPDB Length = 395 Score = 37.7 bits (86), Expect = 0.008, Method: Compositional matrix adjust. Identities = 29/127 (22%), Positives = 59/127 (46%), Gaps = 13/127 (10%) Query: 135 GSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHE-HEYVHGDIKASNLLLNYKNPDQV 193 G L ++ + A R + + ++S+ ++ L Y+ E H+ +H D+K SN+L+N + ++ Sbjct: 150 GGSLDQVLK-KAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRG--EI 206 Query: 194 YLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQ 253 L D+ GV + + GT + S + G S + D+ +G +++ Sbjct: 207 KLCDF---------GVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVE 257 Query: 254 WLTGHLP 260 G P Sbjct: 258 MAVGRYP 264 >5IG1-A nrPDB Length = 344 Score = 37.7 bits (86), Expect = 0.008, Method: Compositional matrix adjust. Identities = 18/43 (41%), Positives = 27/43 (62%), Gaps = 1/43 (2%) Query: 160 RILDILEYIHEHEYVHGDIKASNLLLNYKNPDQ-VYLVDYGLA 201 +IL L++ H +H D+K NLLL K+P+ V + D+GLA Sbjct: 124 QILSALQHCHSKNIIHRDLKPENLLLASKDPNAPVKITDFGLA 166 >3HKO-A nrPDB Length = 345 Score = 37.7 bits (86), Expect = 0.008, Method: Compositional matrix adjust. Identities = 39/200 (19%), Positives = 78/200 (39%), Gaps = 33/200 (16%) Query: 34 KKEWKVGLPIGQGGFGCIYLADMNSSESVGS----DAPCVVKVEPSDNGPLFTELKFYQR 89 +K++ + IGQG +G + +A N + ++ + + + ++ P D + TE++ ++ Sbjct: 25 QKKYHLKGAIGQGSYGVVRVAIENQTRAIRAIKIMNKNKIRQINPKDVERIKTEVRLMKK 84 Query: 90 AAKPEQIQKWIRTRKLKYLGVPKYWGSGLH----------DKNGKSYRFMIMDRFGSDLQ 139 P + + +Y+ + G H D GK MD + + Sbjct: 85 LHHPNIARLYEVYEDEQYICLVMELCHGGHLLDKLNVFIDDSTGKC----AMDVVKTQIC 140 Query: 140 KIYEANAKRFS---------------RKTVLQLSLRILDILEYIHEHEYVHGDIKASNLL 184 E N + + K + + +I L Y+H H DIK N L Sbjct: 141 PCPECNEEAINGSIHGFRESLDFVQREKLISNIMRQIFSALHYLHNQGICHRDIKPENFL 200 Query: 185 LNYKNPDQVYLVDYGLAYRY 204 + ++ LVD+GL+ + Sbjct: 201 FSTNKSFEIKLVDFGLSKEF 220 >1ZWS-A nrPDB Length = 288 Score = 37.7 bits (86), Expect = 0.009, Method: Compositional matrix adjust. Identities = 35/139 (25%), Positives = 60/139 (43%), Gaps = 10/139 (7%) Query: 142 YEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKN--PDQVYLVDYG 199 + A + S + +ILD + Y+H + H D+K N++L KN + L+D+G Sbjct: 105 FLAQKESLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFG 164 Query: 200 LAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHL 259 LA+ +GV E+K GT EF + + N D+ +G L+G Sbjct: 165 LAHE-IEDGV--EFKNIF-----GTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGAS 216 Query: 260 PWEDNLKDPKYVRDSKIRY 278 P+ + K + + Y Sbjct: 217 PFLGDTKQETLANITSVSY 235 >2BPM-A nrPDB Length = 309 Score = 37.7 bits (86), Expect = 0.009, Method: Compositional matrix adjust. Identities = 21/78 (26%), Positives = 39/78 (50%), Gaps = 3/78 (3%) Query: 128 FMIMDRFGSDLQKIYEANAKR-FSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLN 186 +++ + DL+K +A+A + ++L L + H H +H D+K NLL+N Sbjct: 82 YLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN 141 Query: 187 YKNPDQVYLVDYGLAYRY 204 + + L D+GLA + Sbjct: 142 TEG--AIKLADFGLARAF 157 >2F57-A nrPDB Length = 317 Score = 37.7 bits (86), Expect = 0.009, Method: Compositional matrix adjust. Identities = 34/130 (26%), Positives = 63/130 (48%), Gaps = 13/130 (10%) Query: 148 RFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPE 207 R + + + + L +L L Y+H +H DIK+ ++LL + ++ L D+G +C + Sbjct: 137 RMNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLT--SDGRIKLSDFG----FCAQ 190 Query: 208 GVHKEYKEDPKR-CHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPW--EDN 264 KE PKR GT + + + + + D+ LG +I+ + G P+ E Sbjct: 191 ----VSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPP 246 Query: 265 LKDPKYVRDS 274 L+ + +RDS Sbjct: 247 LQAMRRIRDS 256 >6DTL-A nrPDB Length = 364 Score = 37.7 bits (86), Expect = 0.010, Method: Compositional matrix adjust. Identities = 48/178 (26%), Positives = 78/178 (43%), Gaps = 21/178 (11%) Query: 26 GEIITDMAKKEWKVGLPIGQGGFGCIYLADMNS--SESVGSDAPCVVKVEPSDNGPLFTE 83 G I AK + + +PIG+G +G I + MNS +ESV D E Sbjct: 22 GNIFEVTAKYKPPI-MPIGKGAYG-IVCSAMNSETNESVAIKKIANAFDNKIDAKRTLRE 79 Query: 84 LKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYE 143 +K + + + R + +P + +D ++ + +DL +I Sbjct: 80 IKLLRHMDH----ENIVAIRDI----IPPPLRNAFNDV------YIAYELMDTDLHQIIR 125 Query: 144 ANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 +N + S + +IL L+YIH +H D+K SNLLLN N D + + D+GLA Sbjct: 126 SN-QALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLN-ANCD-LKICDFGLA 180 >4AN9-A nrPDB Length = 301 Score = 37.7 bits (86), Expect = 0.010, Method: Compositional matrix adjust. Identities = 30/127 (23%), Positives = 63/127 (49%), Gaps = 13/127 (10%) Query: 135 GSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHE-HEYVHGDIKASNLLLNYKNPDQV 193 G L ++ + A R + + ++S+ ++ L Y+ E H+ +H D+K SN+L+N + ++ Sbjct: 91 GGSLDQVLK-KAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRG--EI 147 Query: 194 YLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQ 253 L D+G++ + E + E+ GT + S + G S + D+ +G +++ Sbjct: 148 KLCDFGVSGQLIDE-MANEFV--------GTRSYMSPERLQGTHYSVQSDIWSMGLSLVE 198 Query: 254 WLTGHLP 260 G P Sbjct: 199 MAVGRYP 205 >2YAB-A nrPDB Length = 361 Score = 37.4 bits (85), Expect = 0.010, Method: Compositional matrix adjust. Identities = 33/121 (27%), Positives = 55/121 (45%), Gaps = 10/121 (8%) Query: 160 RILDILEYIHEHEYVHGDIKASNLLLNYKN--PDQVYLVDYGLAYRYCPEGVHKEYKEDP 217 +ILD + Y+H + H D+K N++L KN + L+D+GLA+ +GV E+K Sbjct: 123 QILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHE-IEDGV--EFKNIF 179 Query: 218 KRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIR 277 GT EF + + N D+ +G L+G P+ + K + + Sbjct: 180 -----GTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVS 234 Query: 278 Y 278 Y Sbjct: 235 Y 235 >4EWQ-A nrPDB Length = 383 Score = 37.4 bits (85), Expect = 0.010, Method: Compositional matrix adjust. Identities = 23/74 (31%), Positives = 41/74 (55%), Gaps = 4/74 (5%) Query: 128 FMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY 187 +++ G+DL I ++ + V L +IL L+YIH + +H D+K SNL +N Sbjct: 126 YLVTHLMGADLNNI--VKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNE 183 Query: 188 KNPDQVYLVDYGLA 201 ++ ++D+GLA Sbjct: 184 DC--ELKILDFGLA 195 >4NIF-A nrPDB Length = 333 Score = 37.4 bits (85), Expect = 0.010, Method: Compositional matrix adjust. Identities = 42/160 (26%), Positives = 64/160 (40%), Gaps = 27/160 (16%) Query: 118 LHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGD 177 ++D Y + R G L KI K FS + + I +EY+H VH D Sbjct: 70 VYDDGKHVYLVTELMRGGELLDKILRQ--KFFSEREASFVLHTIGKTVEYLHSQGVVHRD 127 Query: 178 IKASNLLL--NYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNG 235 +K SN+L NP+ + + D+G A + R +G + T N Sbjct: 128 LKPSNILYVDESGNPECLRICDFGFAKQL--------------RAENGLL-MTPCYTANF 172 Query: 236 VAPS---RRG-----DLEILGYCMIQWLTGHLPWEDNLKD 267 VAP R+G D+ LG + L G+ P+ + D Sbjct: 173 VAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSD 212 >2A27-A nrPDB Length = 321 Score = 37.4 bits (85), Expect = 0.011, Method: Compositional matrix adjust. Identities = 33/121 (27%), Positives = 55/121 (45%), Gaps = 10/121 (8%) Query: 160 RILDILEYIHEHEYVHGDIKASNLLLNYKN--PDQVYLVDYGLAYRYCPEGVHKEYKEDP 217 +ILD + Y+H + H D+K N++L KN + L+D+GLA+ +GV E+K Sbjct: 123 QILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHE-IEDGV--EFKNIF 179 Query: 218 KRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIR 277 GT EF + + N D+ +G L+G P+ + K + + Sbjct: 180 -----GTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVS 234 Query: 278 Y 278 Y Sbjct: 235 Y 235 >6AO5-A nrPDB Length = 362 Score = 37.4 bits (85), Expect = 0.011, Method: Compositional matrix adjust. Identities = 40/163 (24%), Positives = 71/163 (43%), Gaps = 31/163 (19%) Query: 43 IGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRT 102 +G+G +G ++ A S V + V+ SD + E+ Q+ P Sbjct: 18 LGEGSYGSVFKAIHKESGQVVAIKQVPVE---SDLQEIIKEISIMQQCDSPY-------- 66 Query: 103 RKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFG----SDLQKIYEANAKRFSRKTVLQLS 158 V KY+GS + + +++M+ G SD+ ++ T+L+ + Sbjct: 67 -------VVKYYGSYFKNTD----LWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKST 115 Query: 159 LRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 L+ L EY+H +H +IKA N+LLN + L D+G+A Sbjct: 116 LKGL---EYLHFMRKIHRNIKAGNILLNTEG--HAKLADFGVA 153 >3EQC-A nrPDB Length = 360 Score = 37.4 bits (85), Expect = 0.012, Method: Compositional matrix adjust. Identities = 29/127 (22%), Positives = 59/127 (46%), Gaps = 13/127 (10%) Query: 135 GSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHE-HEYVHGDIKASNLLLNYKNPDQV 193 G L ++ + A R + + ++S+ ++ L Y+ E H+ +H D+K SN+L+N + ++ Sbjct: 115 GGSLDQVLK-KAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRG--EI 171 Query: 194 YLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQ 253 L D+ GV + + GT + S + G S + D+ +G +++ Sbjct: 172 KLCDF---------GVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVE 222 Query: 254 WLTGHLP 260 G P Sbjct: 223 MAVGRYP 229 >3F3Z-A nrPDB Length = 277 Score = 37.0 bits (84), Expect = 0.014, Method: Compositional matrix adjust. Identities = 17/47 (36%), Positives = 26/47 (55%), Gaps = 1/47 (2%) Query: 161 ILDILEYIHEHEYVHGDIKASNLLLNYKNPDQ-VYLVDYGLAYRYCP 206 +L + Y H+ H D+K N L +PD + L+D+GLA R+ P Sbjct: 115 VLSAVAYCHKLNVAHRDLKPENFLFLTDSPDSPLKLIDFGLAARFKP 161 >5XVU-A nrPDB Length = 332 Score = 37.0 bits (84), Expect = 0.014, Method: Compositional matrix adjust. Identities = 19/59 (32%), Positives = 35/59 (59%), Gaps = 1/59 (1%) Query: 148 RFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCP 206 +F+ K + +IL L+Y H +H D+K N++++++N Q+ L+ +GLA Y P Sbjct: 121 KFTDKDIRYYIYQILKALDYCHSQGIMHRDVKPHNIMIDHEN-RQIRLISWGLAEFYHP 178 >3PP0-A nrPDB Length = 338 Score = 37.0 bits (84), Expect = 0.014, Method: Compositional matrix adjust. Identities = 21/68 (30%), Positives = 37/68 (54%), Gaps = 3/68 (4%) Query: 134 FGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQV 193 +G L + E N R + +L ++I + Y+ + VH D+ A N+L+ K+P+ V Sbjct: 102 YGCLLDHVRE-NRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLV--KSPNHV 158 Query: 194 YLVDYGLA 201 + D+GLA Sbjct: 159 KITDFGLA 166 >5FET-A nrPDB Length = 847 Score = 37.0 bits (84), Expect = 0.014, Method: Compositional matrix adjust. Identities = 29/109 (26%), Positives = 53/109 (48%), Gaps = 16/109 (14%) Query: 161 ILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRC 220 I+ +EY+HE V+ D+K N+LL+ + V L+D+G A K+ R Sbjct: 642 IILAIEYLHERNIVYRDLKPENILLDKQG--YVKLIDFGCA------------KKIQGRA 687 Query: 221 HD--GTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKD 267 + GT + + + G D+ LG C+ +++ G LP+ ++ +D Sbjct: 688 YTLVGTPHYMAPEVILGKGYGCTVDIWALGVCLYEFICGPLPFGNDQED 736 >4LG4-A nrPDB Length = 299 Score = 37.0 bits (84), Expect = 0.014, Method: Compositional matrix adjust. Identities = 40/163 (24%), Positives = 71/163 (43%), Gaps = 31/163 (19%) Query: 43 IGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRT 102 +G+G +G ++ A S V + V+ SD + E+ Q+ P Sbjct: 19 LGEGSYGSVFKAIHKESGQVVAIKQVPVE---SDLQEIIKEISIMQQCDSPY-------- 67 Query: 103 RKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFG----SDLQKIYEANAKRFSRKTVLQLS 158 V KY+GS + + +++M+ G SD+ ++ T+L+ + Sbjct: 68 -------VVKYYGSYFKNTD----LWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKST 116 Query: 159 LRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 L+ L EY+H +H +IKA N+LLN + L D+G+A Sbjct: 117 LKGL---EYLHFMRKIHRNIKAGNILLNTEG--HAKLADFGVA 154 >3H4J-B nrPDB Length = 336 Score = 37.0 bits (84), Expect = 0.015, Method: Compositional matrix adjust. Identities = 60/261 (22%), Positives = 97/261 (37%), Gaps = 54/261 (20%) Query: 129 MIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYK 188 M+++ G +L Y KR + + +I+ +EY H H+ VH D+K NLLL+ Sbjct: 86 MVIEYAGGELFD-YIVEKKRMTEDEGRRFFQQIICAIEYCHRHKIVHRDLKPENLLLD-- 142 Query: 189 NPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRG------ 242 + V + D+GL+ DG TS + N AP Sbjct: 143 DNLNVKIADFGLS----------------NIMTDGNFLKTSCGSPNYAAPEVINGKLYAG 186 Query: 243 ---DLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRYRENIASLMDKC---FPEKNKP 296 D+ G + L G LP++D + N+ ++ C P+ P Sbjct: 187 PEVDVWSCGIVLYVMLVGRLPFDD-------------EFIPNLFKKVNSCVYVMPDFLSP 233 Query: 297 GE--------IAKYMETVKLLDYTEKPLYE-NLRDILLQGLKAIGSKDDGKLDLSVVENG 347 G +A M+ + + + P + NL D L + GS D ++ + E Sbjct: 234 GAQSLIRRMIVADPMQRITIQEIRRDPWFNVNLPDYLRPMEEVQGSYADSRIVSKLGEAM 293 Query: 348 GLKAKTITKK-RKKEIEESKE 367 G I + R E E KE Sbjct: 294 GFSEDYIVEALRSDENNEVKE 314 >2PZI-A nrPDB Length = 681 Score = 37.0 bits (84), Expect = 0.015, Method: Compositional matrix adjust. Identities = 41/179 (22%), Positives = 70/179 (39%), Gaps = 30/179 (16%) Query: 31 DMAKKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVK--VEPSDNGPLFTEL--- 84 D+ +++V I GG G IYLA D N + P V+K V D + Sbjct: 76 DIVAGQYEVKGCIAHGGLGWIYLALDRNVNGR-----PVVLKGLVHSGDAEAQAMAMAER 130 Query: 85 KFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEA 144 +F P +Q + D++G +++M+ G Q + + Sbjct: 131 QFLAEVVHPSIVQIFNFVEHT--------------DRHGDPVGYIVMEYVGG--QSLKRS 174 Query: 145 NAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYR 203 ++ + L IL L Y+H V+ D+K N++L +Q+ L+D G R Sbjct: 175 KGQKLPVAEAIAYLLEILPALSYLHSIGLVYNDLKPENIMLTE---EQLKLIDLGAVSR 230 >4Y12-A nrPDB Length = 375 Score = 37.0 bits (84), Expect = 0.016, Method: Compositional matrix adjust. Identities = 21/84 (25%), Positives = 40/84 (47%), Gaps = 5/84 (5%) Query: 120 DKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIK 179 D++G +++M+ G Q + + ++ + L IL L Y+H V+ D+K Sbjct: 191 DRHGDPVGYIVMEYVGG--QSLKRSKGQKLPVAEAIAYLLEILPALSYLHSIGLVYNDLK 248 Query: 180 ASNLLLNYKNPDQVYLVDYGLAYR 203 N++L +Q+ L+D G R Sbjct: 249 PENIMLTE---EQLKLIDLGAVSR 269 >4CQG-A nrPDB Length = 331 Score = 37.0 bits (84), Expect = 0.016, Method: Compositional matrix adjust. Identities = 35/147 (23%), Positives = 70/147 (47%), Gaps = 9/147 (6%) Query: 119 HDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDI 178 H K+ FM+++ Y + R S + + +IL + Y+H Y H D+ Sbjct: 74 HVLETKNKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQILSAVAYVHSQGYAHRDL 133 Query: 179 KASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVA- 237 K NLL + + ++ L+D+GL + P+G +K+Y + C G++ + + + G + Sbjct: 134 KPENLLFDENH--KLKLIDFGLCAK--PKG-NKDYH--LQEC-CGSLAYAAPELIQGKSY 185 Query: 238 PSRRGDLEILGYCMIQWLTGHLPWEDN 264 D+ +G + + G LP++D+ Sbjct: 186 LGSEADVWSMGILLYVLMCGFLPFDDD 212 >4CZT-A nrPDB Length = 464 Score = 37.0 bits (84), Expect = 0.016, Method: Compositional matrix adjust. Identities = 27/114 (23%), Positives = 49/114 (42%), Gaps = 24/114 (21%) Query: 160 RILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKR 219 ++++ ++Y H H D+K NLLL+ +V D+GL+ P++ Sbjct: 119 QLINAVDYCHSRGVYHRDLKPENLLLDANGALKVS--DFGLSAL-------------PQQ 163 Query: 220 CHDGTIEFTSIDAHNGVAP---------SRRGDLEILGYCMIQWLTGHLPWEDN 264 + + T+ N VAP + DL G + + G+LP+ED+ Sbjct: 164 VREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDS 217 >5ZTN-A nrPDB Length = 429 Score = 37.0 bits (84), Expect = 0.017, Method: Compositional matrix adjust. Identities = 35/146 (23%), Positives = 64/146 (43%), Gaps = 29/146 (19%) Query: 129 MIMDRFGSDLQKIYEANA-KRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY 187 M + +L ++ + N + FS V + + IL L+ +H++ +H D+K N+LL Sbjct: 176 MTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQ 235 Query: 188 KNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAP-----SRRG 242 + + ++D+G C++ +T I + AP +R G Sbjct: 236 QGRSGIKVIDFG------------------SSCYEHQRVYTYIQSRFYRAPEVILGARYG 277 Query: 243 ---DLEILGYCMIQWLTGH--LPWED 263 D+ LG + + LTG+ LP ED Sbjct: 278 MPIDMWSLGCILAELLTGYPLLPGED 303 >3LMG-A nrPDB Length = 344 Score = 36.6 bits (83), Expect = 0.018, Method: Compositional matrix adjust. Identities = 21/64 (32%), Positives = 35/64 (54%), Gaps = 2/64 (3%) Query: 152 KTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHK 211 + +L ++I + Y+ EH VH ++ A N+LL K+P QV + D+G+A P+ Sbjct: 133 QLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLL--KSPSQVQVADFGVADLLPPDDKQL 190 Query: 212 EYKE 215 Y E Sbjct: 191 LYSE 194 >4FR4-A nrPDB Length = 384 Score = 36.6 bits (83), Expect = 0.018, Method: Compositional matrix adjust. Identities = 37/177 (20%), Positives = 72/177 (40%), Gaps = 31/177 (17%) Query: 31 DMAKKEWKVGLPIGQGGFGCIYLADMNSSESV-----GSDAPCVVKVEPSDNGPLFTELK 85 D+ +++ IG+G FG + + N ++ + + CV + E + +F EL+ Sbjct: 11 DVNFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRN---VFKELQ 67 Query: 86 FYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYEA 144 Q P + W + + FM++D G DL+ + Sbjct: 68 IMQGLEHPFLVNLW-------------------YSFQDEEDMFMVVDLLLGGDLRYHLQQ 108 Query: 145 NAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 N F +TV ++ L+Y+ +H D+K N+LL+ V++ D+ +A Sbjct: 109 NV-HFKEETVKLFICELVMALDYLQNQRIIHRDMKPDNILLDEHG--HVHITDFNIA 162 >3LM0-A nrPDB Length = 327 Score = 36.6 bits (83), Expect = 0.020, Method: Compositional matrix adjust. Identities = 45/170 (26%), Positives = 75/170 (44%), Gaps = 24/170 (14%) Query: 146 AKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNP-DQVYLVDYGLAYRY 204 A+ S V++L +IL+ + Y+H++ VH D+K N+LL+ P + +VD+G++ + Sbjct: 125 AEMVSENDVIRLIKQILEGVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKI 184 Query: 205 CPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPW--E 262 G E +E GT E+ + + N + D+ +G LT P+ E Sbjct: 185 ---GHACELREIM-----GTPEYLAPEILNYDPITTATDMWNIGIIAYMLLTHTSPFVGE 236 Query: 263 DNLKDPKYVRDSKIRYREN------------IASLMDKCFPEKNKPGEIA 300 DN + + + Y E I SL+ K PEK EI Sbjct: 237 DNQETYLNISQVNVDYSEETFSSVSQLATDFIQSLLVKN-PEKRPTAEIC 285 >6FD3-A nrPDB Length = 300 Score = 36.6 bits (83), Expect = 0.020, Method: Compositional matrix adjust. Identities = 16/46 (34%), Positives = 26/46 (56%), Gaps = 2/46 (4%) Query: 162 LDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPE 207 L L+++H ++ +H DIK+ N+LL V L D+G + PE Sbjct: 128 LQALDFLHSNQVIHRDIKSDNILLGMDG--SVKLTDFGFCAQITPE 171 >2Y7J-A nrPDB Length = 365 Score = 36.6 bits (83), Expect = 0.020, Method: Compositional matrix adjust. Identities = 33/141 (23%), Positives = 59/141 (41%), Gaps = 8/141 (5%) Query: 123 GKSYRFMIMD--RFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKA 180 S+ F++ D R G + E A S K + +L+ + ++H + VH D+K Sbjct: 171 SSSFMFLVFDLMRKGELFDYLTEKVA--LSEKETRSIMRSLLEAVSFLHANNIVHRDLKP 228 Query: 181 SNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSR 240 N+LL+ + Q+ L D+G + P +E P ++ + + H G + Sbjct: 229 ENILLD--DNMQIRLSDFGFSCHLEPGEKLRELCGTPGYLAPEILKCSMDETHPGYG--K 284 Query: 241 RGDLEILGYCMIQWLTGHLPW 261 DL G + L G P+ Sbjct: 285 EVDLWACGVILFTLLAGSPPF 305 >3M42-A nrPDB Length = 299 Score = 36.6 bits (83), Expect = 0.021, Method: Compositional matrix adjust. Identities = 20/82 (24%), Positives = 39/82 (47%), Gaps = 3/82 (3%) Query: 123 GKSYRFMIMDRF--GSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKA 180 G+ ++M+ G +I + + F+ + ++ I + ++Y+H H D+K Sbjct: 86 GRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKP 145 Query: 181 SNLLLNYKNPDQVY-LVDYGLA 201 NLL K P+ + L D+G A Sbjct: 146 ENLLYTSKRPNAILKLTDFGFA 167 >4KRC-A nrPDB Length = 317 Score = 36.6 bits (83), Expect = 0.022, Method: Compositional matrix adjust. Identities = 28/92 (30%), Positives = 47/92 (51%), Gaps = 10/92 (10%) Query: 118 LHDKNGKSYRFMIMDRFGSDLQKIYEA----NAKR-FSRKTVLQLSLRILDILEYIHEHE 172 +H +N + F MD +DL+K ++ N R V ++L L + HE++ Sbjct: 72 IHTENKLTLVFEFMD---NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENK 128 Query: 173 YVHGDIKASNLLLNYKNPDQVYLVDYGLAYRY 204 +H D+K NLL+N + Q+ L D+GLA + Sbjct: 129 ILHRDLKPQNLLINKRG--QLKLGDFGLARAF 158 >3KA0-A nrPDB Length = 320 Score = 36.2 bits (82), Expect = 0.022, Method: Compositional matrix adjust. Identities = 20/82 (24%), Positives = 39/82 (47%), Gaps = 3/82 (3%) Query: 123 GKSYRFMIMDRF--GSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKA 180 G+ ++M+ G +I + + F+ + ++ I + ++Y+H H D+K Sbjct: 84 GRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKP 143 Query: 181 SNLLLNYKNPDQVY-LVDYGLA 201 NLL K P+ + L D+G A Sbjct: 144 ENLLYTSKRPNAILKLTDFGFA 165 >2XIK-A nrPDB Length = 294 Score = 36.2 bits (82), Expect = 0.022, Method: Compositional matrix adjust. Identities = 30/92 (32%), Positives = 48/92 (52%), Gaps = 7/92 (7%) Query: 110 VPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIH 169 + +Y+GS L K+ K + M GS L + + T+L+ IL L+Y+H Sbjct: 79 ITRYFGSYL--KSTKLWIIMEYLGGGSALDLLKPGPLEETYIATILR---EILKGLDYLH 133 Query: 170 EHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 +H DIKA+N+LL+ + V L D+G+A Sbjct: 134 SERKIHRDIKAANVLLSEQG--DVKLADFGVA 163 >1NY3-A nrPDB Length = 400 Score = 36.2 bits (82), Expect = 0.023, Method: Compositional matrix adjust. Identities = 20/82 (24%), Positives = 39/82 (47%), Gaps = 3/82 (3%) Query: 123 GKSYRFMIMDRF--GSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKA 180 G+ ++M+ G +I + + F+ + ++ I + ++Y+H H D+K Sbjct: 130 GRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKP 189 Query: 181 SNLLLNYKNPDQVY-LVDYGLA 201 NLL K P+ + L D+G A Sbjct: 190 ENLLYTSKRPNAILKLTDFGFA 211 >6DBM-A nrPDB Length = 318 Score = 36.2 bits (82), Expect = 0.023, Method: Compositional matrix adjust. Identities = 22/61 (36%), Positives = 37/61 (60%), Gaps = 4/61 (6%) Query: 154 VLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEY 213 +L + +I + + Y+H Y+H D+ A N+LL+ N V + D+GLA + PEG H+ Y Sbjct: 136 LLLFAQQICEGMAYLHSQHYIHRDLAARNVLLD--NDRLVKIGDFGLA-KAVPEG-HEYY 191 Query: 214 K 214 + Sbjct: 192 R 192 >2OZA-A nrPDB Length = 356 Score = 36.2 bits (82), Expect = 0.023, Method: Compositional matrix adjust. Identities = 20/82 (24%), Positives = 39/82 (47%), Gaps = 3/82 (3%) Query: 123 GKSYRFMIMDRF--GSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKA 180 G+ ++M+ G +I + + F+ + ++ I + ++Y+H H D+K Sbjct: 86 GRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKP 145 Query: 181 SNLLLNYKNPDQVY-LVDYGLA 201 NLL K P+ + L D+G A Sbjct: 146 ENLLYTSKRPNAILKLTDFGFA 167 >4AU8-A nrPDB Length = 296 Score = 36.2 bits (82), Expect = 0.024, Method: Compositional matrix adjust. Identities = 27/109 (24%), Positives = 48/109 (44%), Gaps = 13/109 (11%) Query: 118 LHDKNGKSYRFMIMDRF-GSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHG 176 LHD + ++ F DL+K +++ + V ++L L + H +H Sbjct: 70 LHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHR 129 Query: 177 DIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTI 225 D+K NLL+N ++ L D+GLA + G+ P RC+ + Sbjct: 130 DLKPQNLLINRNG--ELKLADFGLARAF---GI-------PVRCYSAEV 166 >5DYK-A nrPDB Length = 853 Score = 36.2 bits (82), Expect = 0.025, Method: Compositional matrix adjust. Identities = 29/109 (26%), Positives = 53/109 (48%), Gaps = 16/109 (14%) Query: 161 ILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRC 220 I+ +EY+HE V+ D+K N+LL+ + V L+D+G A K+ R Sbjct: 648 IILAIEYLHERNIVYRDLKPENILLDKQG--YVKLIDFGCA------------KKVQGRA 693 Query: 221 HD--GTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKD 267 + GT + + + G D+ LG C+ +++ G LP+ ++ +D Sbjct: 694 YTLVGTPHYMAPEVILGKGYGCTVDIWALGICLYEFICGPLPFGNDEED 742 >4FG9-A nrPDB Length = 320 Score = 36.2 bits (82), Expect = 0.027, Method: Compositional matrix adjust. Identities = 37/155 (23%), Positives = 66/155 (42%), Gaps = 27/155 (17%) Query: 118 LHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGD 177 +++ G Y M + G +I E ++ + +L ++LD ++Y+H+ VH D Sbjct: 84 IYESGGHLYLIMQLVSGGELFDRIVEKGF--YTERDASRLIFQVLDAVKYLHDLGIVHRD 141 Query: 178 IKASNLLLNYKNPD-QVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGV 236 +K NLL + D ++ + D+GL+ EDP G++ T+ V Sbjct: 142 LKPENLLYYSLDEDSKIMISDFGLSKM-----------EDP-----GSVLSTACGTPGYV 185 Query: 237 AP--------SRRGDLEILGYCMIQWLTGHLPWED 263 AP S+ D +G L G+ P+ D Sbjct: 186 APEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYD 220 >3OZ6-A nrPDB Length = 388 Score = 36.2 bits (82), Expect = 0.027, Method: Compositional matrix adjust. Identities = 21/78 (26%), Positives = 40/78 (51%), Gaps = 4/78 (5%) Query: 128 FMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY 187 +++ D +DL + AN K + L + +++Y+H +H D+K SN+LLN Sbjct: 87 YLVFDYMETDLHAVIRANILEPVHKQYVVYQL--IKVIKYLHSGGLLHRDMKPSNILLNA 144 Query: 188 KNPDQVYLVDYGLAYRYC 205 + V + D+GL+ + Sbjct: 145 EC--HVKVADFGLSRSFV 160 >4JRN-A nrPDB Length = 372 Score = 36.2 bits (82), Expect = 0.029, Method: Compositional matrix adjust. Identities = 46/188 (24%), Positives = 79/188 (42%), Gaps = 34/188 (18%) Query: 40 GLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKV-----EPSDNGPL--------FTELK 85 G P+G GGF +Y A D+ ++E + VKV EP+D L + Sbjct: 73 GAPLGSGGFATVYEATDVETNEELA------VKVFMSEKEPTDETMLDLQRESSCYRNFS 126 Query: 86 FYQRAAKPEQIQKWIRTRKLKYL-GVPKYWGS--GLHDKNGKSYRFMIMDRFGSDLQKIY 142 + A ++ +++ + L G P GL + +Y F++M R +D+ K+ Sbjct: 127 LAKTAKDAQESCRFMVPSDVVMLEGQPASTEVVIGLTTRWVPNY-FLLMMRAEADMSKVI 185 Query: 143 E-------ANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYL 195 N F + LS + + ++ + VH DIK +N LL +++L Sbjct: 186 SWVFGDASVNKSEFGLVVRMYLSSQAIKLVANVQAQGIVHTDIKPANFLLLKDG--RLFL 243 Query: 196 VDYGLAYR 203 D+G YR Sbjct: 244 GDFG-TYR 250 >5DMZ-A nrPDB Length = 365 Score = 35.8 bits (81), Expect = 0.031, Method: Compositional matrix adjust. Identities = 14/39 (35%), Positives = 25/39 (64%) Query: 147 KRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLL 185 K + V+ ++R+L ++E +H+ E +HGDIK N +L Sbjct: 167 KVMPQGLVISFAMRMLYMIEQVHDCEIIHGDIKPDNFIL 205 >3MIA-A nrPDB Length = 351 Score = 35.8 bits (81), Expect = 0.031, Method: Compositional matrix adjust. Identities = 20/74 (27%), Positives = 40/74 (54%), Gaps = 2/74 (2%) Query: 128 FMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY 187 +++ D DL + +F+ + ++ +L+ L YIH ++ +H D+KA+N+L+ Sbjct: 100 YLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITR 159 Query: 188 KNPDQVYLVDYGLA 201 + L D+GLA Sbjct: 160 DG--VLKLADFGLA 171 >4AW2-A nrPDB Length = 437 Score = 35.8 bits (81), Expect = 0.032, Method: Compositional matrix adjust. Identities = 39/159 (24%), Positives = 65/159 (40%), Gaps = 23/159 (14%) Query: 114 WGSGLH----DKNGKSYRFMIMDRF-GSDLQKIYEANAKRFSRKTVLQLSLRILDILEYI 168 W + LH D N +++MD + G DL + R + ++ ++ + Sbjct: 135 WITTLHYAFQDDNN---LYLVMDYYVGGDLLTLLSKFEDRLPEEMARFYLAEMVIAIDSV 191 Query: 169 HEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFT 228 H+ YVH DIK N+L++ + L D+G + +G + GT ++ Sbjct: 192 HQLHYVHRDIKPDNILMDMNG--HIRLADFGSCLKLMEDGTVQ------SSVAVGTPDYI 243 Query: 229 S---IDAHNGVAPSRRG---DLEILGYCMIQWLTGHLPW 261 S + A G R G D LG CM + L G P+ Sbjct: 244 SPEILQAMEG-GKGRYGPECDWWSLGVCMYEMLYGETPF 281 >5D7A-A nrPDB Length = 308 Score = 35.8 bits (81), Expect = 0.035, Method: Compositional matrix adjust. Identities = 17/41 (41%), Positives = 27/41 (65%), Gaps = 2/41 (4%) Query: 161 ILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 IL L ++H+H+ +H DIK N+LL +V LVD+G++ Sbjct: 131 ILRGLSHLHQHKVIHRDIKGQNVLLTENA--EVKLVDFGVS 169 >3NIZ-A nrPDB Length = 311 Score = 35.8 bits (81), Expect = 0.038, Method: Compositional matrix adjust. Identities = 22/87 (25%), Positives = 43/87 (49%), Gaps = 5/87 (5%) Query: 118 LHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGD 177 +H + + F M++ DL+K+ + N + ++L + + H+H +H D Sbjct: 88 IHSERCLTLVFEFMEK---DLKKVLDENKTGLQDSQIKIYLYQLLRGVAHCHQHRILHRD 144 Query: 178 IKASNLLLNYKNPDQVYLVDYGLAYRY 204 +K NLL+N + + L D+GLA + Sbjct: 145 LKPQNLLIN--SDGALKLADFGLARAF 169 >3MN3-A nrPDB Length = 271 Score = 35.8 bits (81), Expect = 0.038, Method: Compositional matrix adjust. Identities = 25/81 (30%), Positives = 42/81 (51%), Gaps = 17/81 (20%) Query: 128 FMIMDRFGSDL-------QKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKA 180 M+++ G++L K+ E A+RF ++ I+ +EY H H+ VH D+K Sbjct: 80 IMVIEYAGNELFDYIVQRDKMSEQEARRFFQQ--------IISAVEYCHRHKIVHRDLKP 131 Query: 181 SNLLLNYKNPDQVYLVDYGLA 201 NLLL+ V + D+GL+ Sbjct: 132 ENLLLD--EHLNVKIADFGLS 150 >3UIU-A nrPDB Length = 306 Score = 35.4 bits (80), Expect = 0.038, Method: Compositional matrix adjust. Identities = 32/122 (26%), Positives = 55/122 (45%), Gaps = 12/122 (9%) Query: 135 GSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVY 194 G+ Q I + ++ + L+L +I ++YIH + +H D+K SN+ L + QV Sbjct: 119 GTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFL--VDTKQVK 176 Query: 195 LVDYGLAYRYCPEGVHKEYKEDPKRCHD-GTIEFTSIDAHNGVAPSRRGDLEILGYCMIQ 253 + D+GL K D KR GT+ + S + + + DL LG + + Sbjct: 177 IGDFGLV---------TSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAE 227 Query: 254 WL 255 L Sbjct: 228 LL 229 >4REW-A nrPDB Length = 540 Score = 35.4 bits (80), Expect = 0.039, Method: Compositional matrix adjust. Identities = 36/146 (24%), Positives = 55/146 (37%), Gaps = 27/146 (18%) Query: 128 FMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY 187 FM+M+ Y R K +L +IL ++Y H H VH D+K N+LL+ Sbjct: 82 FMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDA 141 Query: 188 KNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRG----- 242 ++ D+GL+ DG TS + N AP Sbjct: 142 HMNAKI--ADFGLS----------------NMMSDGEFLRTSCGSPNYAAPEVISGRLYA 183 Query: 243 ----DLEILGYCMIQWLTGHLPWEDN 264 D+ G + L G LP++D+ Sbjct: 184 GPEVDIWSSGVILYALLCGTLPFDDD 209 >3A8W-A nrPDB Length = 345 Score = 35.4 bits (80), Expect = 0.039, Method: Compositional matrix adjust. Identities = 41/174 (23%), Positives = 72/174 (41%), Gaps = 27/174 (15%) Query: 99 WIRTRKLKYLGVPKY-WGSGLHDKNGKSYRFMIMDRF--GSDL-------QKIYEANAKR 148 W++T K + + + GLH R + + G DL +K+ E +A+ Sbjct: 55 WVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARF 114 Query: 149 FSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEG 208 +S + L L+ Y+HE ++ D+K N+LL+ + + L DYG+ C EG Sbjct: 115 YSAEISLALN--------YLHERGIIYRDLKLDNVLLDSEG--HIKLTDYGM----CKEG 160 Query: 209 VHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWE 262 + D GT + + + G D LG M + + G P++ Sbjct: 161 LR---PGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFD 211 >5LPZ-A nrPDB Length = 332 Score = 35.4 bits (80), Expect = 0.039, Method: Compositional matrix adjust. Identities = 75/334 (22%), Positives = 126/334 (37%), Gaps = 37/334 (11%) Query: 43 IGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRT 102 IG GGFG +Y A + +V ++ V + E+ E I K I+ Sbjct: 25 IGSGGFGDVYKAILKDGSAVAIKK--LIHVSGQGDREFMAEM---------ETIGK-IKH 72 Query: 103 RKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKR--FSRKTVLQLSLR 160 R L VP + D+ Y FM L +A K +R+ + S R Sbjct: 73 RNL----VPLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSAR 128 Query: 161 ILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRC 220 L L + +H D+K+SN+LL+ +V D+G+A H Sbjct: 129 GLAFLHHNCSPHIIHRDMKSSNVLLDENLEARVS--DFGMARLMSAMDTHLSVS-----T 181 Query: 221 HDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWED-NLKDPKYVRDSKIRYR 279 GT + + + S +GD+ G +++ LTG P + + D V K + Sbjct: 182 LAGTPGYVPPEYYQSFRCSTKGDVYSYGVVLLELLTGKRPTDSPDFGDNNLVGWVKQHAK 241 Query: 280 ENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENL--RDILLQGLKAI-----G 332 I+ + D +++ EI E ++ L L + R ++Q + G Sbjct: 242 LRISDVFDPELMKEDPALEI----ELLQHLKVAVACLDDRAWRRPTMVQVMAMFKEIQAG 297 Query: 333 SKDDGKLDLSVVENGGLKAKTITKKRKKEIEESK 366 S D + + +E+GG + KE+ E K Sbjct: 298 SGIDSQSTIRSIEDGGFSTIEMVDMSIKEVPEGK 331 >6F3F-A nrPDB Length = 455 Score = 35.4 bits (80), Expect = 0.041, Method: Compositional matrix adjust. Identities = 43/182 (23%), Positives = 73/182 (40%), Gaps = 40/182 (21%) Query: 32 MAKKEWKVG-------LPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTEL 84 +AK W++ + +GQG FG +++ N + V + ++P P Sbjct: 177 LAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVA-----IKTLKPGTMSPE---- 227 Query: 85 KFYQRAAKPEQIQKWIRTRKLKYLGV-----PKYWGSGLHDKNGKSYRFMIMDRFGSDLQ 139 F Q A Q+ K +R KL L P Y + +K GS L Sbjct: 228 AFLQEA----QVMKKLRHEKLVQLYAVVSEEPIYIVTEYMNK-------------GSLLD 270 Query: 140 KIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYG 199 + K ++ +S +I + Y+ YVH D++A+N+L+ +V D+G Sbjct: 271 FLKGETGKYLRLPQLVDMSAQIASGMAYVERMNYVHRDLRAANILVGENLVCKV--ADFG 328 Query: 200 LA 201 LA Sbjct: 329 LA 330 >4E93-A nrPDB Length = 377 Score = 35.4 bits (80), Expect = 0.042, Method: Compositional matrix adjust. Identities = 32/164 (19%), Positives = 65/164 (39%), Gaps = 22/164 (13%) Query: 39 VGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQK 98 +G IG+G FG ++ + + ++ + C + P E + ++ + P + Sbjct: 118 LGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHPNIV-- 175 Query: 99 WIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYEANAKRFSRKTVLQL 157 + +GV K +++M+ G D R KT+LQ+ Sbjct: 176 -------RLIGV----------CTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQM 218 Query: 158 SLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 +EY+ +H D+ A N L+ KN + + D+G++ Sbjct: 219 VGDAAAGMEYLESKCCIHRDLAARNCLVTEKN--VLKISDFGMS 260 >1PHK-A nrPDB Length = 298 Score = 35.4 bits (80), Expect = 0.044, Method: Compositional matrix adjust. Identities = 31/137 (22%), Positives = 56/137 (40%), Gaps = 4/137 (2%) Query: 125 SYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLL 184 ++ F++ D Y S K ++ +L+++ +H+ VH D+K N+L Sbjct: 97 TFFFLVFDLMKKGELFDYLTEKVTLSEKETRKIMRALLEVICALHKLNIVHRDLKPENIL 156 Query: 185 LNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDL 244 L+ + + L D+G + + P +E P IE + D H G + D+ Sbjct: 157 LD--DDMNIKLTDFGFSCQLDPGEKLREVCGTPSYLAPEIIECSMNDNHPGYG--KEVDM 212 Query: 245 EILGYCMIQWLTGHLPW 261 G M L G P+ Sbjct: 213 WSTGVIMYTLLAGSPPF 229 >2W4O-A nrPDB Length = 349 Score = 35.4 bits (80), Expect = 0.047, Method: Compositional matrix adjust. Identities = 17/43 (39%), Positives = 27/43 (62%), Gaps = 1/43 (2%) Query: 160 RILDILEYIHEHEYVHGDIKASNLLLNYKNPDQ-VYLVDYGLA 201 +IL+ + Y+HE+ VH D+K NLL PD + + D+GL+ Sbjct: 156 QILEAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLS 198 >4TNB-A nrPDB Length = 590 Score = 35.0 bits (79), Expect = 0.053, Method: Compositional matrix adjust. Identities = 37/132 (28%), Positives = 59/132 (44%), Gaps = 19/132 (14%) Query: 135 GSDLQ-KIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQV 193 G DL+ IY F + L + IL LE +H V+ D+K N+LL+ + + Sbjct: 268 GGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHHENTVYRDLKPENILLD--DYGHI 325 Query: 194 YLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHN----GVAPSRRGDLEILGY 249 + D GLA + PEG D R GT+ + + + N G++P G LG Sbjct: 326 RISDLGLAVKI-PEG-------DLIRGRVGTVGYMAPEVLNNQRYGLSPDYWG----LGC 373 Query: 250 CMIQWLTGHLPW 261 + + + G P+ Sbjct: 374 LIYEMIEGQSPF 385 >4OLI-A nrPDB Length = 645 Score = 35.0 bits (79), Expect = 0.053, Method: Compositional matrix adjust. Identities = 21/61 (34%), Positives = 37/61 (60%), Gaps = 4/61 (6%) Query: 154 VLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEY 213 +L + +I + + Y+H Y+H ++ A N+LL+ N V + D+GLA + PEG H+ Y Sbjct: 458 LLLFAQQICEGMAYLHSQHYIHRNLAARNVLLD--NDRLVKIGDFGLA-KAVPEG-HEYY 513 Query: 214 K 214 + Sbjct: 514 R 514 >4CFF-A nrPDB Length = 571 Score = 35.0 bits (79), Expect = 0.053, Method: Compositional matrix adjust. Identities = 35/145 (24%), Positives = 53/145 (36%), Gaps = 27/145 (18%) Query: 128 FMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY 187 FM+M+ Y R +L +IL ++Y H H VH D+K N+LL+ Sbjct: 109 FMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDA 168 Query: 188 KNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRG----- 242 ++ D+GL+ DG TS + N AP Sbjct: 169 HMNAKI--ADFGLS----------------NMMSDGEFLRTSCGSPNYAAPEVISGRLYA 210 Query: 243 ----DLEILGYCMIQWLTGHLPWED 263 D+ G + L G LP++D Sbjct: 211 GPEVDIWSCGVILYALLCGTLPFDD 235 >6CCF-A nrPDB Length = 290 Score = 35.0 bits (79), Expect = 0.055, Method: Compositional matrix adjust. Identities = 34/126 (26%), Positives = 56/126 (44%), Gaps = 20/126 (15%) Query: 143 EANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAY 202 E A+ + R +L L EY+H + VH DIK SNLLL + V + D+G++ Sbjct: 128 EEQARLYLRDVILGL--------EYLHCQKIVHRDIKPSNLLLG--DDGHVKIADFGVSN 177 Query: 203 RYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRG---DLEILGYCMIQWLTGHL 259 ++ EG + GT F + +A + S G D+ G + ++ G Sbjct: 178 QF--EGNDAQLSSTA-----GTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKC 230 Query: 260 PWEDNL 265 P+ D+ Sbjct: 231 PFIDDF 236 >3NIE-A nrPDB Length = 429 Score = 35.0 bits (79), Expect = 0.056, Method: Compositional matrix adjust. Identities = 48/194 (24%), Positives = 93/194 (47%), Gaps = 28/194 (14%) Query: 13 SSAKRHLAEQFAVGEIITDM-AKKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVV 70 SS + +L Q G II ++ +++ IG+G +G +YLA D N++++V + Sbjct: 8 SSGRENLYFQ---GAIIKNVKVPDNYEIKHLIGRGSYGYVYLAYDKNANKNVA-----IK 59 Query: 71 KVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTR---KLKYLGVPKYWGSGLHDKNGKSYR 127 KV +F +L +R + I +++ +L L +P+ D Sbjct: 60 KV-----NRMFEDLIDCKRILREITILNRLKSDYIIRLHDLIIPE-------DLLKFDEL 107 Query: 128 FMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY 187 +++++ SDL+K+++ + + V + +L ++IHE +H D+K +N LLN Sbjct: 108 YIVLEIADSDLKKLFKT-PIFLTEQHVKTILYNLLLGEKFIHESGIIHRDLKPANCLLNQ 166 Query: 188 KNPDQVYLVDYGLA 201 V + D+GLA Sbjct: 167 DC--SVKICDFGLA 178 >4CFH-A nrPDB Length = 493 Score = 35.0 bits (79), Expect = 0.061, Method: Compositional matrix adjust. Identities = 36/146 (24%), Positives = 55/146 (37%), Gaps = 27/146 (18%) Query: 128 FMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY 187 FM+M+ Y R K +L +IL ++Y H H VH D+K N+LL+ Sbjct: 109 FMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDA 168 Query: 188 KNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRG----- 242 ++ D+GL+ DG TS + N AP Sbjct: 169 HMNAKI--ADFGLS----------------NMMSDGEFLRTSCGSPNYAAPEVISGRLYA 210 Query: 243 ----DLEILGYCMIQWLTGHLPWEDN 264 D+ G + L G LP++D+ Sbjct: 211 GPEVDIWSSGVILYALLCGTLPFDDD 236 >3GUB-A nrPDB Length = 295 Score = 35.0 bits (79), Expect = 0.061, Method: Compositional matrix adjust. Identities = 29/122 (23%), Positives = 55/122 (45%), Gaps = 12/122 (9%) Query: 160 RILDILEYIHEHEYVHGDIKASNLLL---NYKNPDQVYLVDYGLAYRYCPEGVHKEYKED 216 +IL+ + Y+H + H D+K N++L N P ++ ++D+GLA++ ++ + Sbjct: 122 QILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKP-RIKIIDFGLAHKI-------DFGNE 173 Query: 217 PKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKI 276 K GT EF + + N D+ +G L+G P+ + K S + Sbjct: 174 FKNIF-GTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAV 232 Query: 277 RY 278 Y Sbjct: 233 NY 234 >4E7W-A nrPDB Length = 394 Score = 35.0 bits (79), Expect = 0.063, Method: Compositional matrix adjust. Identities = 43/163 (26%), Positives = 69/163 (42%), Gaps = 25/163 (15%) Query: 43 IGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRT 102 IG G FG ++ A + V SD + KV + +F R + +I K Sbjct: 48 IGNGSFGVVFQAKL-----VESDEVAIKKV--------LQDKRFKNRELQIMRIVKHPNV 94 Query: 103 RKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSL--- 159 LK ++ +G DK + + ++++ + + AK +L + L Sbjct: 95 VDLKAF----FYSNG--DKKDEVFLNLVLEYVPETVYRASRHYAKLKQTMPMLLIKLYMY 148 Query: 160 RILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVY-LVDYGLA 201 ++L L YIH H DIK NLLL+ P V L+D+G A Sbjct: 149 QLLRSLAYIHSIGICHRDIKPQNLLLD--PPSGVLKLIDFGSA 189 >4B6L-A nrPDB Length = 281 Score = 34.7 bits (78), Expect = 0.065, Method: Compositional matrix adjust. Identities = 63/247 (25%), Positives = 102/247 (41%), Gaps = 49/247 (19%) Query: 28 IITD-MAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKF 86 +ITD + + + G +G+GGF Y A + S + VKV P Sbjct: 1 LITDPRSGRTYLKGRLLGKGGFARCYEATDTETGSAYA-----VKVIPQS---------- 45 Query: 87 YQRAAKPEQIQKWIRT----RKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIY 142 R AKP Q +K + R L++ + ++ S + Y F+ + S L I+ Sbjct: 46 --RVAKPHQREKILNEIELHRDLQHRHIVRF--SHHFEDADNIYIFLELCSRKS-LAHIW 100 Query: 143 EANAKRFSRKTVLQLSLR-----ILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVD 197 +A R T+L+ +R IL L+Y+H+ +H D+K N + ++ + D Sbjct: 101 KA------RHTLLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFITENM--ELKVGD 152 Query: 198 YGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTS--IDAHNGVAPSRRGDLEILGYCMIQWL 255 +GLA R P E K+ GT + + + G P D+ LG M L Sbjct: 153 FGLAARLEP-------PEQRKKTICGTPNYVAPEVLLRQGHGPE--ADVWSLGCVMYTLL 203 Query: 256 TGHLPWE 262 G P+E Sbjct: 204 CGSPPFE 210 >1BYG-A nrPDB Length = 278 Score = 34.7 bits (78), Expect = 0.066, Method: Compositional matrix adjust. Identities = 40/166 (24%), Positives = 73/166 (43%), Gaps = 23/166 (13%) Query: 35 KEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPE 94 KE K+ IG+G FG + L D ++ VK +D T F A+ Sbjct: 21 KELKLLQTIGKGEFGDVMLGDYRGNK-------VAVKCIKNDA----TAQAFLAEASVMT 69 Query: 95 QIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTV 154 Q++ + ++ LGV GL+ + ++D S + + + + Sbjct: 70 QLR---HSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDC-------L 119 Query: 155 LQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGL 200 L+ SL + + +EY+ + +VH D+ A N+L++ N +V D+GL Sbjct: 120 LKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVS--DFGL 163 >1K9A-A nrPDB Length = 450 Score = 34.7 bits (78), Expect = 0.070, Method: Compositional matrix adjust. Identities = 40/167 (23%), Positives = 73/167 (43%), Gaps = 23/167 (13%) Query: 35 KEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPE 94 KE K+ IG+G FG + L D ++ VK +D T F A+ Sbjct: 193 KELKLLQTIGKGEFGDVMLGDYRGNK-------VAVKCIKNDA----TAQAFLAEASVMT 241 Query: 95 QIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTV 154 Q++ + ++ LGV GL+ + ++D S + + + + Sbjct: 242 QLR---HSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDC-------L 291 Query: 155 LQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 L+ SL + + +EY+ + +VH D+ A N+L++ N +V D+GL Sbjct: 292 LKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKV--SDFGLT 336 >5EZV-A nrPDB Length = 560 Score = 34.7 bits (78), Expect = 0.072, Method: Compositional matrix adjust. Identities = 35/145 (24%), Positives = 53/145 (36%), Gaps = 27/145 (18%) Query: 128 FMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY 187 FM+M+ Y R +L +IL ++Y H H VH D+K N+LL+ Sbjct: 104 FMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDA 163 Query: 188 KNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRG----- 242 ++ D+GL+ DG TS + N AP Sbjct: 164 HMNAKI--ADFGLS----------------NMMSDGEFLRTSCGSPNYAAPEVISGRLYA 205 Query: 243 ----DLEILGYCMIQWLTGHLPWED 263 D+ G + L G LP++D Sbjct: 206 GPEVDIWSCGVILYALLCGTLPFDD 230 >1CM8-A nrPDB Length = 367 Score = 34.7 bits (78), Expect = 0.074, Method: Compositional matrix adjust. Identities = 21/74 (28%), Positives = 40/74 (54%), Gaps = 4/74 (5%) Query: 128 FMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY 187 +++M G+DL K+ + ++ + L ++L L YIH +H D+K NL +N Sbjct: 106 YLVMPFMGTDLGKLMKH--EKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNE 163 Query: 188 KNPDQVYLVDYGLA 201 ++ ++D+GLA Sbjct: 164 DC--ELKILDFGLA 175 >4RED-A nrPDB Length = 351 Score = 34.7 bits (78), Expect = 0.076, Method: Compositional matrix adjust. Identities = 36/146 (24%), Positives = 55/146 (37%), Gaps = 27/146 (18%) Query: 128 FMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY 187 FM+M+ Y R K +L +IL ++Y H H VH D+K N+LL+ Sbjct: 90 FMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDA 149 Query: 188 KNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRG----- 242 ++ D+GL+ DG TS + N AP Sbjct: 150 HMNAKI--ADFGLS----------------NMMSDGEFLRTSCGSPNYAAPEVISGRLYA 191 Query: 243 ----DLEILGYCMIQWLTGHLPWEDN 264 D+ G + L G LP++D+ Sbjct: 192 GPEVDIWSSGVILYALLCGTLPFDDD 217 >3ENH-A nrPDB Length = 540 Score = 34.7 bits (78), Expect = 0.077, Method: Compositional matrix adjust. Identities = 26/111 (23%), Positives = 54/111 (48%), Gaps = 16/111 (14%) Query: 94 EQIQKWIRTRKLKYLGVPKYWGSG---LHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFS 150 E I+K R+ +YL + K +G + D + + R M+ G + + E N Sbjct: 379 ENIRKSRTAREARYLALVKDFGIPAPYIFDVDLDNKRIMMSYINGKLAKDVIEDN----- 433 Query: 151 RKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 L ++ +I +I+ +H+++ +H D+ SN + + +Y++D+GL Sbjct: 434 ----LDIAYKIGEIVGKLHKNDVIHNDLTTSNFIFD----KDLYIIDFGLG 476 >5WNO-A nrPDB Length = 330 Score = 34.7 bits (78), Expect = 0.079, Method: Compositional matrix adjust. Identities = 30/159 (18%), Positives = 66/159 (41%), Gaps = 17/159 (10%) Query: 43 IGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRT 102 +G G FG ++ + P +KV +D ++ E +++ Sbjct: 30 LGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTD------------QSQTDEMLEEATNM 77 Query: 103 RKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRIL 162 +L++ + K G +HD K + + R +LQ + + + + + +I Sbjct: 78 FRLRHDNLLKIIGFCMHDDGLK---IVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIA 134 Query: 163 DILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 ++Y+ + VH D+ N+L+ K + V + D+GL+ Sbjct: 135 SGMQYLEKQRVVHRDLATRNVLV--KKFNHVEITDFGLS 171 >2QNJ-A nrPDB Length = 328 Score = 34.7 bits (78), Expect = 0.079, Method: Compositional matrix adjust. Identities = 49/229 (21%), Positives = 93/229 (40%), Gaps = 34/229 (14%) Query: 43 IGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKW-- 99 IG+G F + LA + + V ++ P+ LF E++ + P ++ + Sbjct: 20 IGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEV 79 Query: 100 IRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSL 159 I T K YL + + SG G+ + +++ ++ E A+ R+ Sbjct: 80 IETEKTLYLIME--YASG-----GEVFDYLVAH------GRMKEKEARSKFRQ------- 119 Query: 160 RILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKR 219 I+ ++Y H+ VH D+KA NLLL+ + + D+G + + G + P Sbjct: 120 -IVSAVQYCHQKRIVHRDLKAENLLLDADM--NIKIADFGFSNEFTVGGKLDTFCGSPPY 176 Query: 220 CHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWE-DNLKD 267 + D D+ LG + ++G LP++ NLK+ Sbjct: 177 AAPELFQGKKYDGPE-------VDVWSLGVILYTLVSGSLPFDGQNLKE 218 >4APC-A nrPDB Length = 350 Score = 34.7 bits (78), Expect = 0.082, Method: Compositional matrix adjust. Identities = 22/82 (26%), Positives = 39/82 (47%), Gaps = 2/82 (2%) Query: 120 DKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIK 179 ++NG Y M G ++I F +L ++I L+++H+ + +H DIK Sbjct: 93 EENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVHDRKILHRDIK 152 Query: 180 ASNLLLNYKNPDQVYLVDYGLA 201 + N+ L V L D+G+A Sbjct: 153 SQNIFLT--KDGTVQLGDFGIA 172 >3DAK-A nrPDB Length = 290 Score = 34.7 bits (78), Expect = 0.084, Method: Compositional matrix adjust. Identities = 16/49 (32%), Positives = 30/49 (61%), Gaps = 2/49 (4%) Query: 153 TVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 T+ + +L+ LEY+H++ +H D+KA N+LL Q+ D+G++ Sbjct: 117 TIATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQI--ADFGVS 163 >4KIK-B nrPDB Length = 677 Score = 34.3 bits (77), Expect = 0.085, Method: Compositional matrix adjust. Identities = 38/178 (21%), Positives = 69/178 (38%), Gaps = 19/178 (10%) Query: 29 ITDMAKKEWKVGLPIGQGGFG-CIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFY 87 +T W++ +G GGFG I + + E + C ++ P + E++ Sbjct: 13 LTTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQ-CRQELSPRNRERWCLEIQIM 71 Query: 88 QRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYEA-- 144 +R P + VP+ G+ + + M+ G DL+K Sbjct: 72 RRLTHPNVV---------AARDVPE----GMQNLAPNDLPLLAMEYCQGGDLRKYLNQFE 118 Query: 145 NAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVY-LVDYGLA 201 N +L L I L Y+HE+ +H D+K N++L ++ ++D G A Sbjct: 119 NCCGLREGAILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYA 176 >5UIU-A nrPDB Length = 323 Score = 34.3 bits (77), Expect = 0.088, Method: Compositional matrix adjust. Identities = 27/108 (25%), Positives = 55/108 (50%), Gaps = 11/108 (10%) Query: 165 LEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGT 224 + ++HE+ ++H DIK++N+LL+ ++ D+GLA K + GT Sbjct: 162 INFLHENHHIHRDIKSANILLDEAFTAKIS--DFGLA-----RASEKFAQTVMTSRIVGT 214 Query: 225 IEFTSIDAHNG-VAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYV 271 + + +A G + P + D+ G +++ +TG LP D ++P+ + Sbjct: 215 TAYMAPEALRGEITP--KSDIYSFGVVLLEIITG-LPAVDEHREPQLL 259 >6C9D-A nrPDB Length = 459 Score = 34.3 bits (77), Expect = 0.091, Method: Compositional matrix adjust. Identities = 51/229 (22%), Positives = 92/229 (40%), Gaps = 34/229 (14%) Query: 43 IGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKW-- 99 IG+G F + LA + + V ++ P+ LF E++ + P ++ + Sbjct: 29 IGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEV 88 Query: 100 IRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSL 159 I T K YL + + SG G+ + +++ K EA AK Sbjct: 89 IETEKTLYLVME--YASG-----GEVFDYLV----AHGRMKEKEARAK----------FR 127 Query: 160 RILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKR 219 +I+ ++Y H+ VH D+KA NLLL+ + + D+G + + E+ P Sbjct: 128 QIVSAVQYCHQKYIVHRDLKAENLLLD--GDMNIKIADFGFSNEFTVGNKLDEFCGSPPY 185 Query: 220 CHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWE-DNLKD 267 + D D+ LG + ++G LP++ NLK+ Sbjct: 186 AAPELFQGKKYDGP-------EVDVWSLGVILYTLVSGSLPFDGQNLKE 227 >5U6C-A nrPDB Length = 315 Score = 34.3 bits (77), Expect = 0.093, Method: Compositional matrix adjust. Identities = 34/169 (20%), Positives = 69/169 (40%), Gaps = 18/169 (10%) Query: 39 VGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGP------LFTELKFYQRAAK 92 +G +G+G FG + ++ + G+ VK DN +E + + Sbjct: 40 LGKILGEGEFGSVMEGNLKQED--GTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSH 97 Query: 93 PEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRK 152 P ++ ++ G+PK K G + +++ R E K + Sbjct: 98 PNVMRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRL--------ETGPKHIPLQ 149 Query: 153 TVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 T+L+ + I +EY+ ++H D+ A N +L ++ V + D+GL+ Sbjct: 150 TLLKFMVDIALGMEYLSNRNFLHRDLAARNCML--RDDMTVCVADFGLS 196 >4UY9-A nrPDB Length = 323 Score = 34.3 bits (77), Expect = 0.094, Method: Compositional matrix adjust. Identities = 47/201 (23%), Positives = 82/201 (40%), Gaps = 33/201 (16%) Query: 135 GSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYV---HGDIKASNLLLNYK--N 189 G L ++ + KR ++ +++I + Y+H+ V H D+K+SN+L+ K N Sbjct: 92 GGPLNRVL--SGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVEN 149 Query: 190 PDQ----VYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLE 245 D + + D+GLA +E+ K GT + + + S+ D+ Sbjct: 150 GDLSNKILKITDFGLA---------REWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVW 200 Query: 246 ILGYCMIQWLTGHLPWE--DNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYM 303 G + + LTG +P+ D L V +K+ + C P AK M Sbjct: 201 SYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLAL-----PIPSTC------PEPFAKLM 249 Query: 304 ETVKLLDYTEKPLYENLRDIL 324 E D +P + N+ D L Sbjct: 250 EDCWNPDPHSRPSFTNILDQL 270 >4F9B-A nrPDB Length = 361 Score = 34.3 bits (77), Expect = 0.095, Method: Compositional matrix adjust. Identities = 22/62 (35%), Positives = 32/62 (51%), Gaps = 6/62 (9%) Query: 149 FSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEG 208 S + V + L + L+ IH+ VH D+K SN L N + + LVD+GLA +G Sbjct: 114 LSFQEVREYMLNLFKALKRIHQFGIVHRDVKPSNFLYN-RRLKKYALVDFGLA-----QG 167 Query: 209 VH 210 H Sbjct: 168 TH 169 >4D2V-A nrPDB Length = 356 Score = 34.3 bits (77), Expect = 0.095, Method: Compositional matrix adjust. Identities = 32/138 (23%), Positives = 66/138 (47%), Gaps = 9/138 (6%) Query: 128 FMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY 187 FM+++ Y + R S + + +I+ + Y+H Y H D+K NLL + Sbjct: 103 FMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDE 162 Query: 188 KNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVA-PSRRGDLEI 246 + ++ L+D+GL + P+G +K+Y + C G + + + + G + D+ Sbjct: 163 YH--KLKLIDFGLCAK--PKG-NKDYHL--QAC-CGALAYAAPELIQGKSYLGSEADVWS 214 Query: 247 LGYCMIQWLTGHLPWEDN 264 +G + + G LP++D+ Sbjct: 215 MGILLYVLMCGFLPFDDD 232 >4BGQ-A nrPDB Length = 304 Score = 34.3 bits (77), Expect = 0.10, Method: Compositional matrix adjust. Identities = 19/57 (33%), Positives = 34/57 (59%), Gaps = 3/57 (5%) Query: 160 RILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKED 216 +++ + + H+++ VH DIK NLL+++ D + L D+G A R EG + Y E+ Sbjct: 119 QLIKAIHWCHKNDIVHRDIKPENLLISHN--DVLKLCDFGFA-RNLSEGNNANYDEE 172 >4U41-A nrPDB Length = 332 Score = 34.3 bits (77), Expect = 0.10, Method: Compositional matrix adjust. Identities = 18/48 (37%), Positives = 28/48 (58%), Gaps = 2/48 (4%) Query: 154 VLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 + +S IL L ++H H +H DIK N+LL +V LVD+G++ Sbjct: 131 IAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENA--EVKLVDFGVS 176 >3TXO-A nrPDB Length = 353 Score = 34.3 bits (77), Expect = 0.10, Method: Compositional matrix adjust. Identities = 31/136 (22%), Positives = 60/136 (44%), Gaps = 11/136 (8%) Query: 128 FMIMDRF-GSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLN 186 F +M+ G DL + ++RF + I+ L ++H+ ++ D+K N+LL+ Sbjct: 100 FFVMEFVNGGDLM-FHIQKSRRFDEARARFYAAEIISALMFLHDKGIIYRDLKLDNVLLD 158 Query: 187 YKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEI 246 ++ L D+G+ C EG+ C GT ++ + + + D Sbjct: 159 HEG--HCKLADFGM----CKEGICNGVTT-ATFC--GTPDYIAPEILQEMLYGPAVDWWA 209 Query: 247 LGYCMIQWLTGHLPWE 262 +G + + L GH P+E Sbjct: 210 MGVLLYEMLCGHAPFE 225 >5AIR-A nrPDB Length = 430 Score = 34.3 bits (77), Expect = 0.11, Method: Compositional matrix adjust. Identities = 44/169 (26%), Positives = 72/169 (42%), Gaps = 36/169 (21%) Query: 43 IGQGGFGCIYLADM-NSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIR 101 IG G FG +Y A + +S E V + KV + +F R + + Sbjct: 72 IGNGSFGVVYQAKLCDSGELVA-----IKKV--------LQDKRFKNRELQIMRKLDHCN 118 Query: 102 TRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRK----TVLQL 157 +L+Y ++ SG +K + Y +++D + ++ A+ +SR V+ + Sbjct: 119 IVRLRYF----FYSSG--EKKDEVYLNLVLDYVPETVYRV----ARHYSRAKQTLPVIYV 168 Query: 158 SLRILDI---LEYIHEHEYVHGDIKASNLLLNYKNPDQVY--LVDYGLA 201 L + + L YIH H DIK NLLL +PD L D+G A Sbjct: 169 KLYMYQLFRSLAYIHSFGICHRDIKPQNLLL---DPDTAVLKLCDFGSA 214 >3IO7-A nrPDB Length = 313 Score = 34.3 bits (77), Expect = 0.11, Method: Compositional matrix adjust. Identities = 37/175 (21%), Positives = 80/175 (45%), Gaps = 19/175 (10%) Query: 29 ITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQ 88 +T ++ K +G+G FG + + + + + V K++ S L+ ++ Sbjct: 22 MTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTE----EHLRDFE 77 Query: 89 RAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDR--FGSDLQKIYEANA 146 R + + L++ + KY G+ G+ +IM+ +GS L+ + + Sbjct: 78 REIEI--------LKSLQHDNIVKY--KGVCYSAGRRNLKLIMEYLPYGS-LRDYLQKHK 126 Query: 147 KRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 +R +LQ + +I +EY+ Y+H D+ N+L+ +N ++V + D+GL Sbjct: 127 ERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILV--ENENRVKIGDFGLT 179 >2WQN-A nrPDB Length = 310 Score = 34.3 bits (77), Expect = 0.11, Method: Compositional matrix adjust. Identities = 34/148 (22%), Positives = 65/148 (43%), Gaps = 14/148 (9%) Query: 91 AKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKI---YEANAK 147 A+ + I++ ++L + V KY+ S + D N + + D DL ++ ++ + Sbjct: 75 ARADCIKEIDLLKQLNHPNVIKYYASFIED-NELNIVLELAD--AGDLSRMIKHFKKQKR 131 Query: 148 RFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPE 207 +TV + +++ LE++H +H DIK +N+ + V L D GL + + Sbjct: 132 LIPERTVWKYFVQLCSALEHMHSRRVMHRDIKPANVFITATG--VVKLGDLGLGRFFSSK 189 Query: 208 G------VHKEYKEDPKRCHDGTIEFTS 229 V Y P+R H+ F S Sbjct: 190 TTAAHSLVGTPYYMSPERIHENGYNFKS 217 >3BGP-A nrPDB Length = 333 Score = 34.3 bits (77), Expect = 0.11, Method: Compositional matrix adjust. Identities = 38/168 (22%), Positives = 76/168 (45%), Gaps = 16/168 (9%) Query: 34 KKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKP 93 + +++VG +G GGFG +Y S V + P +K D + EL R Sbjct: 55 ESQYQVGPLLGSGGFGSVY-----SGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPME 109 Query: 94 EQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKT 153 + K + + + GV + L D + F+++ +Q +++ +R + + Sbjct: 110 VVLLKKVSS---GFSGVIR-----LLDWFERPDSFVLILERPEPVQDLFDFITERGALQE 161 Query: 154 VLQLSL--RILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYG 199 L S ++L+ + + H +H DIK N+L++ N ++ L+D+G Sbjct: 162 ELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDL-NRGELKLIDFG 208 >2VD5-A nrPDB Length = 412 Score = 34.3 bits (77), Expect = 0.11, Method: Compositional matrix adjust. Identities = 23/88 (26%), Positives = 42/88 (47%), Gaps = 4/88 (4%) Query: 114 WGSGLHDK-NGKSYRFMIMDRF-GSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEH 171 W + LH ++Y +++M+ + G DL + +R + I+ ++ +H Sbjct: 122 WITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHRL 181 Query: 172 EYVHGDIKASNLLLNYKNPDQVYLVDYG 199 YVH DIK N+LL+ + L D+G Sbjct: 182 GYVHRDIKPDNILLDRCG--HIRLADFG 207 >5TUR-A nrPDB Length = 404 Score = 33.9 bits (76), Expect = 0.11, Method: Compositional matrix adjust. Identities = 38/168 (22%), Positives = 76/168 (45%), Gaps = 16/168 (9%) Query: 34 KKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKP 93 + +++VG +G GGFG +Y S V + P +K D + EL R Sbjct: 126 ESQYQVGPLLGSGGFGSVY-----SGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPME 180 Query: 94 EQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKT 153 + K + + + GV + L D + F+++ +Q +++ +R + + Sbjct: 181 VVLLKKVSS---GFSGVIR-----LLDWFERPDSFVLILERPEPVQDLFDFITERGALQE 232 Query: 154 VLQLSL--RILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYG 199 L S ++L+ + + H +H DIK N+L++ N ++ L+D+G Sbjct: 233 ELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDL-NRGELKLIDFG 279 >4RC3-A nrPDB Length = 289 Score = 33.9 bits (76), Expect = 0.11, Method: Compositional matrix adjust. Identities = 38/168 (22%), Positives = 76/168 (45%), Gaps = 16/168 (9%) Query: 34 KKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKP 93 + +++VG +G GGFG +Y S V + P +K D + EL R Sbjct: 11 ESQYQVGPLLGSGGFGSVY-----SGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPME 65 Query: 94 EQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKT 153 + K + + + GV + L D + F+++ +Q +++ +R + + Sbjct: 66 VVLLKKVSS---GFSGVIR-----LLDWFERPDSFVLILERPEPVQDLFDFITERGALQE 117 Query: 154 VLQLSL--RILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYG 199 L S ++L+ + + H +H DIK N+L++ N ++ L+D+G Sbjct: 118 ELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDL-NRGELKLIDFG 164 >5LPV-A nrPDB Length = 296 Score = 33.9 bits (76), Expect = 0.12, Method: Compositional matrix adjust. Identities = 53/220 (24%), Positives = 84/220 (38%), Gaps = 25/220 (11%) Query: 43 IGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRT 102 IG GGFG +Y A + +V ++ V + E+ E I K I+ Sbjct: 25 IGSGGFGDVYKAILKDGSAVAIKK--LIHVSGQGDREFMAEM---------ETIGK-IKH 72 Query: 103 RKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKR--FSRKTVLQLSLR 160 R L VP + D+ Y FM L +A K +R+ + S R Sbjct: 73 RNL----VPLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSAR 128 Query: 161 ILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRC 220 L L + +H D+K+SN+LL+ +V D+G+A H Sbjct: 129 GLAFLHHNCSPHIIHRDMKSSNVLLDENLEARVS--DFGMARLMSAMDTHLSVSTLA--- 183 Query: 221 HDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLP 260 GT + + + S +GD+ G +++ LTG P Sbjct: 184 --GTPGYVPPEYYQSFRCSTKGDVYSYGVVLLELLTGKRP 221 >4XI2-A nrPDB Length = 446 Score = 33.9 bits (76), Expect = 0.12, Method: Compositional matrix adjust. Identities = 38/159 (23%), Positives = 71/159 (44%), Gaps = 26/159 (16%) Query: 148 RFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPE 207 RF + +L++ + + +EY+ +++H D+ A N L+N + V + D+GL+ RY Sbjct: 279 RFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVN--DQGVVKVSDFGLS-RYV-- 333 Query: 208 GVHKEYKED-----PKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQ-WLTGHLPW 261 + EY P R + S S + D+ G M + + G +P+ Sbjct: 334 -LDDEYTSSVGSKFPVRWSPPEVLMYS-------KFSSKSDIWAFGVLMWEIYSLGKMPY 385 Query: 262 E--DNLKDPKYVRDSKIRYRENIAS-----LMDKCFPEK 293 E N + +++ YR ++AS +M C+ EK Sbjct: 386 ERFTNSETAEHIAQGLRLYRPHLASERVYTIMYSCWHEK 424 >6E2O-A nrPDB Length = 295 Score = 33.9 bits (76), Expect = 0.12, Method: Compositional matrix adjust. Identities = 28/114 (24%), Positives = 57/114 (50%), Gaps = 10/114 (8%) Query: 150 SRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGV 209 + +T+ + +IL+ L+Y+H+++ VH DIK N+L+N + + + D+G + R G+ Sbjct: 120 NEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYS-GVLKISDFGTSKRLA--GI 176 Query: 210 HKEYKEDPKRCHDGTIEFTS--IDAHNGVAPSRRGDLEILGYCMIQWLTGHLPW 261 + GT+++ + I + D+ LG +I+ TG P+ Sbjct: 177 NP-----CTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPF 225 >2UV2-A nrPDB Length = 325 Score = 33.9 bits (76), Expect = 0.13, Method: Compositional matrix adjust. Identities = 14/44 (31%), Positives = 27/44 (61%), Gaps = 2/44 (4%) Query: 160 RILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYR 203 + LD L Y+H+++ +H D+KA N+L + L D+G++ + Sbjct: 143 QTLDALNYLHDNKIIHRDLKAGNILFTLDG--DIKLADFGVSAK 184 >4M7I-A nrPDB Length = 299 Score = 33.9 bits (76), Expect = 0.13, Method: Compositional matrix adjust. Identities = 35/171 (20%), Positives = 70/171 (40%), Gaps = 30/171 (17%) Query: 43 IGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRT 102 +G+GGFG ++ A K + D ++ R E++ + ++ Sbjct: 13 LGRGGFGVVFEA----------------KNKVDDCNYAIKRIRLPNRELAREKVMREVKA 56 Query: 103 -RKLKYLGVPKYWGS--------GLHDKNGKSYRFMIMDRFGSDLQKIY---EANAKRFS 150 KL++ G+ +Y+ + L + K Y ++ M + K + + Sbjct: 57 LAKLEHPGIVRYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERE 116 Query: 151 RKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 R L + L+I + +E++H +H D+K SN+ D V + D+GL Sbjct: 117 RSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMD--DVVKVGDFGLV 165 >6NPU-A nrPDB Length = 298 Score = 33.9 bits (76), Expect = 0.13, Method: Compositional matrix adjust. Identities = 20/77 (25%), Positives = 40/77 (51%), Gaps = 5/77 (6%) Query: 128 FMIMDRF---GSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLL 184 F I+ F G+ L + E N + + +L ++ +I +EY+ + ++H D+ A N L Sbjct: 97 FYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCL 156 Query: 185 LNYKNPDQVYLVDYGLA 201 + + V + D+GL+ Sbjct: 157 VGENH--LVKVADFGLS 171 >5ES1-A nrPDB Length = 328 Score = 33.9 bits (76), Expect = 0.14, Method: Compositional matrix adjust. Identities = 39/165 (23%), Positives = 67/165 (40%), Gaps = 26/165 (15%) Query: 43 IGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKW-- 99 IG+G F + LA + + V ++ PS LF E++ + P ++ + Sbjct: 23 IGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVKLFEV 82 Query: 100 IRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSL 159 I T K YL V +Y +G + D Y + R K Sbjct: 83 IETEKTLYL-VMEYASAG-----------EVFD---------YLVSHGRMKEKEARAKFR 121 Query: 160 RILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRY 204 +I+ + Y H+ VH D+KA NLLL+ + + + D+G + + Sbjct: 122 QIVSAVHYCHQKNIVHRDLKAENLLLDAE--ANIKIADFGFSNEF 164 >4XEY-B nrPDB Length = 408 Score = 33.5 bits (75), Expect = 0.15, Method: Compositional matrix adjust. Identities = 20/77 (25%), Positives = 40/77 (51%), Gaps = 5/77 (6%) Query: 128 FMIMDRF---GSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLL 184 F I+ F G+ L + E N + + +L ++ +I +EY+ + ++H D+ A N L Sbjct: 196 FYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCL 255 Query: 185 LNYKNPDQVYLVDYGLA 201 + + V + D+GL+ Sbjct: 256 VGENH--LVKVADFGLS 270 >2XYN-A nrPDB Length = 292 Score = 33.5 bits (75), Expect = 0.15, Method: Compositional matrix adjust. Identities = 17/68 (25%), Positives = 37/68 (54%), Gaps = 2/68 (2%) Query: 134 FGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQV 193 +G+ L + E N + + +L ++ +I +EY+ + ++H D+ A N L+ + +V Sbjct: 112 YGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKV 171 Query: 194 YLVDYGLA 201 D+GL+ Sbjct: 172 --ADFGLS 177 >2H8H-A nrPDB Length = 535 Score = 33.5 bits (75), Expect = 0.15, Method: Compositional matrix adjust. Identities = 39/179 (21%), Positives = 74/179 (41%), Gaps = 34/179 (18%) Query: 32 MAKKEWKVG-------LPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTEL 84 +AK W++ + +GQG FG +++ N + V + ++P P Sbjct: 257 LAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVA-----IKTLKPGTMSPE---- 307 Query: 85 KFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF--GSDLQKIY 142 F Q A Q+ K +R KL L + + +++ + GS L + Sbjct: 308 AFLQEA----QVMKKLRHEKLVQL----------YAVVSEEPIYIVTEYMSKGSLLDFLK 353 Query: 143 EANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 K ++ ++ +I + Y+ YVH D++A+N+L+ +V D+GLA Sbjct: 354 GETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKV--ADFGLA 410 >5H2U-A nrPDB Length = 267 Score = 33.5 bits (75), Expect = 0.15, Method: Compositional matrix adjust. Identities = 43/194 (22%), Positives = 85/194 (43%), Gaps = 26/194 (13%) Query: 135 GSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVY 194 GS L+ + +++ K +L ++ ++ + + Y+ Y+H D+ A N+L+ +V Sbjct: 87 GSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILVGENTLCKV- 145 Query: 195 LVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEF--TSIDAHNGVAPSRRGDLEILGYCMI 252 D+GLA + KED HD I + T+ +A + S + D+ G + Sbjct: 146 -GDFGLA---------RLIKEDVYLSHDHNIPYKWTAPEALSRGHYSTKSDVWSFGILLH 195 Query: 253 QWLT-GHLPWEDNLKDPKYVR-DSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLD 310 + + G +P+ ++R D+ R + +C P + K M T D Sbjct: 196 EMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPL-----EC------PPSVHKLMLTCWCRD 244 Query: 311 YTEKPLYENLRDIL 324 ++P ++ LR+ L Sbjct: 245 PEQRPTFKALRERL 258 >4UYA-A nrPDB Length = 340 Score = 33.5 bits (75), Expect = 0.15, Method: Compositional matrix adjust. Identities = 37/161 (22%), Positives = 67/161 (41%), Gaps = 26/161 (16%) Query: 147 KRFSRKTVLQLSLRILDILEYIHEHEYV---HGDIKASNLLLNYKNPD------QVYLVD 197 +R ++ +++I + Y+HE +V H D+K+SN+LL K + + D Sbjct: 119 RRIPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITD 178 Query: 198 YGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTG 257 +GLA +E+ K G + + + S+ D+ G + + LTG Sbjct: 179 FGLA---------REWHRTTKMATAGAYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTG 229 Query: 258 HLPWE--DNLKDPKYVRDSKIRY------RENIASLMDKCF 290 +P+ D L V +K+ E A LM +C+ Sbjct: 230 EVPYRGIDGLAVAYGVAVNKLTLPIPSTCPEPFAKLMKECW 270 >6EWX-A nrPDB Length = 484 Score = 33.5 bits (75), Expect = 0.15, Method: Compositional matrix adjust. Identities = 18/57 (31%), Positives = 30/57 (52%), Gaps = 1/57 (1%) Query: 134 FGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNP 190 F D + A + + R+ L L++ + LE++ EH +H D+ NLLL + NP Sbjct: 193 FVRDSVASHRAEPEVYERRVCFLL-LQLCNGLEHLKEHGIIHRDLCLENLLLVHCNP 248 >2W1I-A nrPDB Length = 326 Score = 33.5 bits (75), Expect = 0.16, Method: Compositional matrix adjust. Identities = 37/174 (21%), Positives = 79/174 (45%), Gaps = 19/174 (10%) Query: 30 TDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQR 89 T ++ K +G+G FG + + + + + V K++ S L+ ++R Sbjct: 36 TQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTE----EHLRDFER 91 Query: 90 AAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDR--FGSDLQKIYEANAK 147 + + L++ + KY G+ G+ +IM+ +GS L+ + + + Sbjct: 92 EIEI--------LKSLQHDNIVKY--KGVCYSAGRRNLKLIMEYLPYGS-LRDYLQKHKE 140 Query: 148 RFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 R +LQ + +I +EY+ Y+H D+ N+L+ +N ++V + D+GL Sbjct: 141 RIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILV--ENENRVKIGDFGLT 192 >6QAU-A nrPDB Length = 280 Score = 33.5 bits (75), Expect = 0.17, Method: Compositional matrix adjust. Identities = 42/177 (23%), Positives = 70/177 (39%), Gaps = 24/177 (13%) Query: 128 FMIMDRF-GSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLN 186 F++M+ G DL +A S T+ +I + +H +H D+K N+LL+ Sbjct: 86 FLVMEYCNGGDLADYLQAKGT-LSEDTIRVFLHQIAAAMRILHSKGIIHRDLKPQNILLS 144 Query: 187 YKNPDQ-------VYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPS 239 Y N + + + D+G A + + P I DA Sbjct: 145 YANRRKSSVSGIRIKIADFGFARYLHSNMMAADLCGSPMYMAPEVIMSQHYDA------- 197 Query: 240 RRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKP 296 + DL +G + Q L G P++ N P+ D ++ Y +N SLM P + P Sbjct: 198 -KADLWSIGTVIYQCLVGKPPFQAN--SPQ---DLRMFYEKN-RSLM-PSIPRETSP 246 >4CRL-A nrPDB Length = 406 Score = 33.5 bits (75), Expect = 0.17, Method: Compositional matrix adjust. Identities = 21/68 (30%), Positives = 37/68 (54%), Gaps = 4/68 (5%) Query: 138 LQKIYEANAK--RFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPD--QV 193 + +AN K + R V L +ILD + Y+H + +H D+K +N+L+ + P+ +V Sbjct: 113 FHRASKANKKPVQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRV 172 Query: 194 YLVDYGLA 201 + D G A Sbjct: 173 KIADMGFA 180 >6E4F-A nrPDB Length = 290 Score = 33.5 bits (75), Expect = 0.17, Method: Compositional matrix adjust. Identities = 15/54 (27%), Positives = 32/54 (59%), Gaps = 2/54 (3%) Query: 148 RFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 RF + +L++ + + +EY+ +++H D+ A N L+N + V + D+GL+ Sbjct: 123 RFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVN--DQGVVKVSDFGLS 174 >4H1J-A nrPDB Length = 293 Score = 33.5 bits (75), Expect = 0.18, Method: Compositional matrix adjust. Identities = 34/130 (26%), Positives = 60/130 (46%), Gaps = 9/130 (6%) Query: 128 FMIMDRFG-SDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLN 186 ++IM+ + +L E N T++ SL+I + Y+ VH DI N+L+ Sbjct: 100 WIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINCVHRDIAVRNILV- 158 Query: 187 YKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEI 246 +P+ V L D+GL+ RY + YK R I++ S ++ N + D+ + Sbjct: 159 -ASPECVKLGDFGLS-RYIED--EDYYKASVTRL---PIKWMSPESINFRRFTTASDVWM 211 Query: 247 LGYCMIQWLT 256 CM + L+ Sbjct: 212 FAVCMWEILS 221 >3HMP-A nrPDB Length = 342 Score = 33.5 bits (75), Expect = 0.18, Method: Compositional matrix adjust. Identities = 28/115 (24%), Positives = 53/115 (46%), Gaps = 21/115 (18%) Query: 160 RILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKR 219 +L+ + IH+H VH D+K +N L+ + L+D+G+A + P+ K Sbjct: 163 NMLEAVHTIHQHGIVHSDLKPANFLI---VDGMLKLIDFGIANQMQPDTTSV-----VKD 214 Query: 220 CHDGTIEFTSIDAHNGVAPSRRG-----------DLEILGYCMIQWLT-GHLPWE 262 GT+ + +A ++ SR D+ LG C++ ++T G P++ Sbjct: 215 SQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLG-CILYYMTYGKTPFQ 268 >2BDW-A nrPDB Length = 362 Score = 33.5 bits (75), Expect = 0.18, Method: Compositional matrix adjust. Identities = 29/103 (28%), Positives = 49/103 (47%), Gaps = 11/103 (10%) Query: 103 RKLKYLGVPKYWGSGLHDK-NGKSYRFMIMDRFGSDLQKIYEANAKR--FSRKTVLQLSL 159 RKL++ + + LHD +S+ +++ D +++E R +S Sbjct: 83 RKLQHPNIVR-----LHDSIQEESFHYLVFDLVTGG--ELFEDIVAREFYSEADASHCIQ 135 Query: 160 RILDILEYIHEHEYVHGDIKASNLLLNYKNPD-QVYLVDYGLA 201 +IL+ + Y H + VH ++K NLLL K V L D+GLA Sbjct: 136 QILESIAYCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLA 178 >6GVJ-A nrPDB Length = 429 Score = 33.5 bits (75), Expect = 0.19, Method: Compositional matrix adjust. Identities = 28/115 (24%), Positives = 53/115 (46%), Gaps = 21/115 (18%) Query: 160 RILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKR 219 +L+ + IH+H VH D+K +N L+ + L+D+G+A + P+ K Sbjct: 251 NMLEAVHTIHQHGIVHSDLKPANFLI---VDGMLKLIDFGIANQMQPDTTSVV-----KD 302 Query: 220 CHDGTIEFTSIDAHNGVAPSRRG-----------DLEILGYCMIQWLT-GHLPWE 262 GT+ + +A ++ SR D+ LG C++ ++T G P++ Sbjct: 303 SQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLG-CILYYMTYGKTPFQ 356 >5G6V-A nrPDB Length = 324 Score = 33.5 bits (75), Expect = 0.19, Method: Compositional matrix adjust. Identities = 19/73 (26%), Positives = 36/73 (49%), Gaps = 2/73 (2%) Query: 129 MIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYK 188 ++ + DL++ + + V ++L L Y H + +H D+K NLL+N + Sbjct: 77 LVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINER 136 Query: 189 NPDQVYLVDYGLA 201 ++ L D+GLA Sbjct: 137 G--ELKLADFGLA 147 >6E9W-A nrPDB Length = 443 Score = 33.1 bits (74), Expect = 0.19, Method: Compositional matrix adjust. Identities = 67/292 (22%), Positives = 113/292 (38%), Gaps = 56/292 (19%) Query: 32 MAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEP---SDNGPLFTELKFYQ 88 M ++++V IG+G FG + L S+ V + + K E SD+ + E Sbjct: 99 MKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYA-MKLLSKFEMIKRSDSAFFWEERDIMA 157 Query: 89 RAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIY----- 142 A P +Q + + +YL +M+M+ G DL + Sbjct: 158 FANSPWVVQLFYAFQDDRYL-------------------YMVMEYMPGGDLVNLMSNYDV 198 Query: 143 -EANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 E A+ ++ + VL L+ IH ++H D+K N+LL+ + L D+G Sbjct: 199 PEKWARFYTAEVVLA--------LDAIHSMGFIHRDVKPDNMLLDKSG--HLKLADFGTC 248 Query: 202 YRYCPEGVHKEYKEDPKRCHD--GTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHL 259 + EG+ RC GT ++ S + V S+ GD G W G Sbjct: 249 MKMNKEGM--------VRCDTAVGTPDYISPE----VLKSQGGD-GYYGRECDWWSVGVF 295 Query: 260 PWEDNLKDPKYVRDSKIRYRENIASLMDK-CFPEKNKPGEIAKYMETVKLLD 310 +E + D + DS + I + + FP+ N + AK + L D Sbjct: 296 LYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTD 347 >5YKS-A nrPDB Length = 377 Score = 33.1 bits (74), Expect = 0.19, Method: Compositional matrix adjust. Identities = 38/167 (22%), Positives = 68/167 (40%), Gaps = 24/167 (14%) Query: 43 IGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKW-- 99 +G+G F + LA + + E V K++ G LF E++ + P ++ + Sbjct: 43 LGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHPNIVRLYEV 102 Query: 100 IRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSL 159 I T+ YL + G + D Y + DL K Y A Sbjct: 103 IDTQTKLYLILELGDGGDMFD-----YIMKHEEGLNEDLAKKYFA--------------- 142 Query: 160 RILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCP 206 +I+ + Y H+ VH D+K N++ ++ V L D+G + ++ P Sbjct: 143 QIVHAISYCHKLHVVHRDLKPENVVF-FEKQGLVKLTDFGFSNKFQP 188 >6FDY-U nrPDB Length = 276 Score = 33.1 bits (74), Expect = 0.20, Method: Compositional matrix adjust. Identities = 14/42 (33%), Positives = 22/42 (52%) Query: 165 LEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCP 206 L+++HE H D+K N+LL+ + L D+G A P Sbjct: 124 LQFLHERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSP 165 >3TKU-A nrPDB Length = 433 Score = 33.1 bits (74), Expect = 0.20, Method: Compositional matrix adjust. Identities = 38/159 (23%), Positives = 67/159 (42%), Gaps = 23/159 (14%) Query: 114 WGSGLHDK-NGKSYRFMIMDRF-GSDL----QKIYEANAKRFSRKTVLQLSLRILDILEY 167 W + LH +++ +++MD + G DL K + + +R + ++ L I + Sbjct: 151 WITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAI----DS 206 Query: 168 IHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEF 227 IH+ YVH DIK N+LL+ + L D+G + +G + GT ++ Sbjct: 207 IHQLHYVHRDIKPDNVLLDVNG--HIRLADFGSCLKMNDDGTVQ------SSVAVGTPDY 258 Query: 228 TSIDAHNGVAPSR-----RGDLEILGYCMIQWLTGHLPW 261 S + + D LG CM + L G P+ Sbjct: 259 ISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPF 297 >4E20-A nrPDB Length = 290 Score = 33.1 bits (74), Expect = 0.21, Method: Compositional matrix adjust. Identities = 21/61 (34%), Positives = 36/61 (59%), Gaps = 4/61 (6%) Query: 154 VLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEY 213 +L + +I + + Y+H Y+H + A N+LL+ N V + D+GLA + PEG H+ Y Sbjct: 113 LLLFAQQICEGMAYLHAQHYIHRALAARNVLLD--NDRLVKIGDFGLA-KAVPEG-HEYY 168 Query: 214 K 214 + Sbjct: 169 R 169 >2A1A-B nrPDB Length = 284 Score = 33.1 bits (74), Expect = 0.21, Method: Compositional matrix adjust. Identities = 31/122 (25%), Positives = 55/122 (45%), Gaps = 12/122 (9%) Query: 135 GSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVY 194 G+ Q I + ++ + L+L +I ++YIH + ++ D+K SN+ L + QV Sbjct: 105 GTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLINRDLKPSNIFL--VDTKQVK 162 Query: 195 LVDYGLAYRYCPEGVHKEYKEDPKRCHD-GTIEFTSIDAHNGVAPSRRGDLEILGYCMIQ 253 + D+GL K D KR GT+ + S + + + DL LG + + Sbjct: 163 IGDFGLV---------TSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAE 213 Query: 254 WL 255 L Sbjct: 214 LL 215 >4Y93-A nrPDB Length = 446 Score = 33.1 bits (74), Expect = 0.21, Method: Compositional matrix adjust. Identities = 14/54 (25%), Positives = 31/54 (57%), Gaps = 2/54 (3%) Query: 148 RFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 RF + +L++ + + +EY+ +++H D+ A N L+N + V + D+G+ Sbjct: 280 RFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVN--DQGVVKVSDFGMT 331 >5FG8-A nrPDB Length = 285 Score = 33.1 bits (74), Expect = 0.22, Method: Compositional matrix adjust. Identities = 26/88 (29%), Positives = 43/88 (48%), Gaps = 6/88 (6%) Query: 118 LHDK-NGKSYRFMIMDRFGSDLQKIYEANAKR--FSRKTVLQLSLRILDILEYIHEHEYV 174 LHD ++Y +++ D +++E R +S +IL+ + + H++ V Sbjct: 78 LHDSIQEENYHYLVFDLVTGG--ELFEDIVAREFYSEADASHCIQQILESVNHCHQNGVV 135 Query: 175 HGDIKASNLLLNYKNPD-QVYLVDYGLA 201 H D+K NLLL K V L D+GLA Sbjct: 136 HRDLKPENLLLASKAKGAAVKLADFGLA 163 >2JAM-A nrPDB Length = 304 Score = 33.1 bits (74), Expect = 0.22, Method: Compositional matrix adjust. Identities = 16/45 (35%), Positives = 29/45 (64%), Gaps = 5/45 (11%) Query: 160 RILDILEYIHEHEYVHGDIKASNLLLNYKNPDQ---VYLVDYGLA 201 ++L ++Y+HE+ VH D+K NLL Y P++ + + D+GL+ Sbjct: 114 QVLSAVKYLHENGIVHRDLKPENLL--YLTPEENSKIMITDFGLS 156 >5GNK-A nrPDB Length = 297 Score = 33.1 bits (74), Expect = 0.23, Method: Compositional matrix adjust. Identities = 21/74 (28%), Positives = 36/74 (48%), Gaps = 3/74 (4%) Query: 128 FMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY 187 M + FG L + E + + +L ++I + Y+ + VH D+ A N+L+ Sbjct: 98 IMQLMPFGCLLDYVRE-HKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLV-- 154 Query: 188 KNPDQVYLVDYGLA 201 K P V + D+GLA Sbjct: 155 KTPQHVKITDFGLA 168 >4LRM-A nrPDB Length = 334 Score = 33.1 bits (74), Expect = 0.23, Method: Compositional matrix adjust. Identities = 20/68 (29%), Positives = 34/68 (50%), Gaps = 3/68 (4%) Query: 134 FGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQV 193 FG L + E + + +L ++I + Y+ + VH D+ A N+L+ K P V Sbjct: 107 FGCLLDYVRE-HKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLV--KTPQHV 163 Query: 194 YLVDYGLA 201 + D+GLA Sbjct: 164 KITDFGLA 171 >3EB0-A nrPDB Length = 383 Score = 33.1 bits (74), Expect = 0.25, Method: Compositional matrix adjust. Identities = 26/101 (25%), Positives = 47/101 (46%), Gaps = 4/101 (3%) Query: 109 GVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILE-- 166 GV + S + + + Y +IM+ L K+ ++ + + +S+ I + Sbjct: 95 GVNNHHKSVIVNPSQNKYLNVIMEYVPDTLHKVLKSFIRSGRSIPMNLISIYIYQLFRAV 154 Query: 167 -YIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCP 206 +IH H DIK NLL+N K+ + + L D+G A + P Sbjct: 155 GFIHSLGICHRDIKPQNLLVNSKD-NTLKLCDFGSAKKLIP 194 >5AP3-A nrPDB Length = 313 Score = 32.7 bits (73), Expect = 0.25, Method: Compositional matrix adjust. Identities = 28/115 (24%), Positives = 53/115 (46%), Gaps = 21/115 (18%) Query: 160 RILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKR 219 +L+ + IH+H VH D+K +N L+ + L+D+G+A + P+ K Sbjct: 135 NMLEAVHTIHQHGIVHSDLKPANFLI---VDGMLKLIDFGIANQMQPDTTSV-----VKD 186 Query: 220 CHDGTIEFTSIDAHNGVAPSRRG-----------DLEILGYCMIQWLT-GHLPWE 262 GT+ + +A ++ SR D+ LG C++ ++T G P++ Sbjct: 187 SQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLG-CILYYMTYGKTPFQ 240 >3PVW-A nrPDB Length = 695 Score = 32.7 bits (73), Expect = 0.25, Method: Compositional matrix adjust. Identities = 36/146 (24%), Positives = 61/146 (41%), Gaps = 15/146 (10%) Query: 117 GLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHG 176 H + S+ +M+ G DL + + FS + + I+ LE++H V+ Sbjct: 260 AFHTPDKLSFILDLMN--GGDLH-YHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYR 316 Query: 177 DIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDA-HNG 235 D+K +N+LL+ V + D GLA + + H GT + + + G Sbjct: 317 DLKPANILLDEHG--HVRISDLGLACDFSKKKPHASV---------GTHGYMAPEVLQKG 365 Query: 236 VAPSRRGDLEILGYCMIQWLTGHLPW 261 VA D LG + + L GH P+ Sbjct: 366 VAYDSSADWFSLGCMLFKLLRGHSPF 391 >3LZB-A nrPDB Length = 327 Score = 32.7 bits (73), Expect = 0.25, Method: Compositional matrix adjust. Identities = 20/68 (29%), Positives = 34/68 (50%), Gaps = 3/68 (4%) Query: 134 FGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQV 193 FG L + E + + +L ++I + Y+ + VH D+ A N+L+ K P V Sbjct: 100 FGCLLDYVRE-HKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLV--KTPQHV 156 Query: 194 YLVDYGLA 201 + D+GLA Sbjct: 157 KITDFGLA 164 >3KK8-A nrPDB Length = 284 Score = 32.7 bits (73), Expect = 0.25, Method: Compositional matrix adjust. Identities = 29/104 (27%), Positives = 49/104 (47%), Gaps = 11/104 (10%) Query: 102 TRKLKYLGVPKYWGSGLHDK-NGKSYRFMIMDRFGSDLQKIYEANAKR--FSRKTVLQLS 158 RKL++ + + LHD +S+ +++ D +++E R +S Sbjct: 59 CRKLQHPNIVR-----LHDSIQEESFHYLVFDLVTGG--ELFEDIVAREFYSEADASHCI 111 Query: 159 LRILDILEYIHEHEYVHGDIKASNLLLNYKNPD-QVYLVDYGLA 201 +IL+ + Y H + VH ++K NLLL K V L D+GLA Sbjct: 112 QQILESIAYCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLA 155 >1TKI-A nrPDB Length = 321 Score = 32.7 bits (73), Expect = 0.26, Method: Compositional matrix adjust. Identities = 28/146 (19%), Positives = 59/146 (40%), Gaps = 10/146 (6%) Query: 118 LHDKNGKSYRFMIMDRFGSDLQKIYEANAKRF--SRKTVLQLSLRILDILEYIHEHEYVH 175 LH+ +++ F S L N F + + ++ ++ + L+++H H H Sbjct: 66 LHESFESMEELVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCEALQFLHSHNIGH 125 Query: 176 GDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNG 235 DI+ N++ + + ++++G A + P D R E+ + + H Sbjct: 126 FDIRPENIIYQTRRSSTIKIIEFGQARQLKP--------GDNFRLLFTAPEYYAPEVHQH 177 Query: 236 VAPSRRGDLEILGYCMIQWLTGHLPW 261 S D+ LG + L+G P+ Sbjct: 178 DVVSTATDMWSLGTLVYVLLSGINPF 203 >2I6L-A nrPDB Length = 320 Score = 32.7 bits (73), Expect = 0.26, Method: Compositional matrix adjust. Identities = 47/178 (26%), Positives = 78/178 (43%), Gaps = 25/178 (14%) Query: 42 PIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWI 100 P+G GG G ++ A D + + V +V +P E+K +R ++ + Sbjct: 18 PLGCGGNGLVFSAVDNDCDKRVAIKK--IVLTDPQSVKHALREIKIIRRLDHDNIVKVF- 74 Query: 101 RTRKLKYLGVPKYWGSGLHDKNGK----SYRFMIMDRFGSDLQKIYEANA--KRFSRKTV 154 + LG P GS L D G + +++ + +DL + E + +R + Sbjct: 75 -----EILG-PS--GSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARLFM 126 Query: 155 LQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLV-DYGLAYRYCPEGVHK 211 QL L L+YIH +H D+K +NL +N + D V + D+GLA P HK Sbjct: 127 YQL----LRGLKYIHSANVLHRDLKPANLFINTE--DLVLKIGDFGLARIMDPHYSHK 178 >3VN9-A nrPDB Length = 340 Score = 32.7 bits (73), Expect = 0.27, Method: Compositional matrix adjust. Identities = 19/78 (24%), Positives = 41/78 (52%), Gaps = 6/78 (7%) Query: 128 FMIMDRFGSDLQKIYEA---NAKRFSRKTVLQLSLRILDILEYIHEH-EYVHGDIKASNL 183 ++ M+ + L K Y+ + + ++++ I+ LE++H +H D+K SN+ Sbjct: 126 WICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNV 185 Query: 184 LLNYKNPDQVYLVDYGLA 201 L+N QV + D+G++ Sbjct: 186 LINALG--QVKMCDFGIS 201 >2YZA-A nrPDB Length = 276 Score = 32.7 bits (73), Expect = 0.27, Method: Compositional matrix adjust. Identities = 21/74 (28%), Positives = 34/74 (45%), Gaps = 2/74 (2%) Query: 128 FMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY 187 FM+M+ Y R +L +IL ++Y H H VH D+K N+LL+ Sbjct: 87 FMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDA 146 Query: 188 KNPDQVYLVDYGLA 201 ++ D+GL+ Sbjct: 147 HMNAKI--ADFGLS 158 >3HDN-A nrPDB Length = 373 Score = 32.7 bits (73), Expect = 0.27, Method: Compositional matrix adjust. Identities = 55/235 (23%), Positives = 84/235 (35%), Gaps = 53/235 (22%) Query: 161 ILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRC 220 I L Y+H V+ D+K N+LL+ + + L D+GL C E + C Sbjct: 148 IASALGYLHSLNIVYRDLKPENILLDSQG--HIVLTDFGL----CKENIEHNSTTS-TFC 200 Query: 221 HDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRYRE 280 GT E+ + + + R D LG + + L G P+ Y Sbjct: 201 --GTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPF----------------YSR 242 Query: 281 NIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDILLQGL------KAIGSK 334 N A + D NKP ++ KP N LL+GL K +G+K Sbjct: 243 NTAEMYDNIL---NKPLQL--------------KPNITNSARHLLEGLLQKDRTKRLGAK 285 Query: 335 DD-----GKLDLSVVENGGLKAKTITKKRKKEIEESKEPGVEDTEWSNTQTEEAI 384 DD + S++ L K IT + + D E++ AI Sbjct: 286 DDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNAI 340 >5U6B-A nrPDB Length = 307 Score = 32.7 bits (73), Expect = 0.28, Method: Compositional matrix adjust. Identities = 20/81 (24%), Positives = 38/81 (46%), Gaps = 10/81 (12%) Query: 121 KNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKA 180 K+G + F++ R G Q +Y + +++ I +EY+ ++H D+ A Sbjct: 113 KHGDLHSFLLYSRLGD--QPVY------LPTQMLVKFMADIASGMEYLSTKRFIHRDLAA 164 Query: 181 SNLLLNYKNPDQVYLVDYGLA 201 N +LN V + D+GL+ Sbjct: 165 RNCMLNENM--SVCVADFGLS 183 >2ZMD-A nrPDB Length = 390 Score = 32.7 bits (73), Expect = 0.28, Method: Compositional matrix adjust. Identities = 15/48 (31%), Positives = 28/48 (58%), Gaps = 3/48 (6%) Query: 160 RILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPE 207 +L+ + IH+H VH D+K +N L+ + L+D+G+A + P+ Sbjct: 163 NMLEAVHTIHQHGIVHSDLKPANFLI---VDGMLKLIDFGIANQMQPD 207 >6BXI-A nrPDB Length = 333 Score = 32.7 bits (73), Expect = 0.28, Method: Compositional matrix adjust. Identities = 40/153 (26%), Positives = 69/153 (45%), Gaps = 8/153 (5%) Query: 53 LADMNSSESVGSDAPCVVK-VEPSDNGPLFTELKFYQRAAKPEQIQ-KWIRTRKLKYLGV 110 L D S + +G A V+ V+ D G ++ +K ++A E+ Q IR + + Sbjct: 5 LEDFESLKVIGRGAFGEVRLVQKKDTGHVYA-MKILRKADMLEKEQVGHIRAERDILVEA 63 Query: 111 PKYWGSGL-HDKNGKSYRFMIMDRF-GSDLQKIYEANAKRFSRKTVLQLSLRILDILEYI 168 W + + K ++IM+ G D+ + +T ++ +L I + I Sbjct: 64 DSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAI-DSI 122 Query: 169 HEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 H+ ++H DIK NLLL+ K V L D+GL Sbjct: 123 HQLGFIHRDIKPDNLLLDSKG--HVKLSDFGLC 153 >2HAK-A nrPDB Length = 328 Score = 32.7 bits (73), Expect = 0.29, Method: Compositional matrix adjust. Identities = 39/166 (23%), Positives = 71/166 (42%), Gaps = 26/166 (15%) Query: 43 IGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKW-- 99 IG+G F + LA + + V ++ P+ LF E++ + P ++ + Sbjct: 23 IGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEV 82 Query: 100 IRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSL 159 I T K YL + + SG G+ + +++ K EA AK Sbjct: 83 IETEKTLYLVME--YASG-----GEVFDYLV----AHGRMKEKEARAK----------FR 121 Query: 160 RILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYC 205 +I+ ++Y H+ VH D+KA NLLL+ + + D+G + + Sbjct: 122 QIVSAVQYCHQKYIVHRDLKAENLLLD--GDMNIKIADFGFSNEFT 165 >4MD7-E nrPDB Length = 391 Score = 32.7 bits (73), Expect = 0.29, Method: Compositional matrix adjust. Identities = 16/46 (34%), Positives = 30/46 (65%), Gaps = 1/46 (2%) Query: 161 ILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCP 206 IL L+Y H +H D+K N+++++++ ++ L+D+GLA Y P Sbjct: 140 ILKALDYCHSMGIMHRDVKPHNVMIDHEH-RKLRLIDWGLAEFYHP 184 >5UUU-A nrPDB Length = 547 Score = 32.3 bits (72), Expect = 0.32, Method: Compositional matrix adjust. Identities = 36/146 (24%), Positives = 61/146 (41%), Gaps = 15/146 (10%) Query: 117 GLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHG 176 H + S+ +M+ G DL + + FS + + I+ LE++H V+ Sbjct: 269 AFHTPDKLSFILDLMN--GGDLH-YHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYR 325 Query: 177 DIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDA-HNG 235 D+K +N+LL+ V + D GLA + + H GT + + + G Sbjct: 326 DLKPANILLDEHG--HVRISDLGLACDFSKKKPHASV---------GTHGYMAPEVLQKG 374 Query: 236 VAPSRRGDLEILGYCMIQWLTGHLPW 261 VA D LG + + L GH P+ Sbjct: 375 VAYDSSADWFSLGCMLFKLLRGHSPF 400 >4LFI-A nrPDB Length = 374 Score = 32.3 bits (72), Expect = 0.32, Method: Compositional matrix adjust. Identities = 16/46 (34%), Positives = 29/46 (63%), Gaps = 1/46 (2%) Query: 159 LRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRY 204 +L L+Y H +H D+K N+++++KN ++ L+D+GLA Y Sbjct: 179 FELLKALDYCHSMGIMHRDVKPHNVMIDHKNK-KLRLIDWGLAEFY 223 >3QUP-A nrPDB Length = 323 Score = 32.3 bits (72), Expect = 0.32, Method: Compositional matrix adjust. Identities = 37/179 (20%), Positives = 75/179 (41%), Gaps = 23/179 (12%) Query: 32 MAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVK------VEPSDNGPLFTE-- 83 + ++++ +G +G+G FG + A + + GS VK + SD E Sbjct: 20 IPEQQFTLGRMLGKGEFGSVREAQLKQED--GSFVKVAVKMLKADIIASSDIEEFLREAA 77 Query: 84 -LKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIY 142 +K + + + +R+R L +P + K+G + F++ R G Sbjct: 78 CMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFM--KHGDLHAFLLASRIGE------ 129 Query: 143 EANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 N +T+++ + I +EY+ ++H D+ A N +L V + D+GL+ Sbjct: 130 --NPFNLPLQTLVRFMVDIACGMEYLSSRNFIHRDLAARNCML--AEDMTVCVADFGLS 184 >2FO0-A nrPDB Length = 495 Score = 32.3 bits (72), Expect = 0.34, Method: Compositional matrix adjust. Identities = 19/77 (24%), Positives = 40/77 (51%), Gaps = 5/77 (6%) Query: 128 FMIMDRF---GSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLL 184 F I+ F G+ L + E N + + +L ++ +I +EY+ + ++H ++ A N L Sbjct: 288 FYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRNLAARNCL 347 Query: 185 LNYKNPDQVYLVDYGLA 201 + + V + D+GL+ Sbjct: 348 VGENH--LVKVADFGLS 362 >4WB7-A nrPDB Length = 405 Score = 32.3 bits (72), Expect = 0.35, Method: Compositional matrix adjust. Identities = 18/56 (32%), Positives = 30/56 (53%), Gaps = 2/56 (3%) Query: 148 RFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYR 203 RFS + +I+ EY+H + ++ D+K NLL++ + QV D+G A R Sbjct: 192 RFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQV--TDFGFAKR 245 >5OAT-A nrPDB Length = 411 Score = 32.3 bits (72), Expect = 0.39, Method: Compositional matrix adjust. Identities = 23/74 (31%), Positives = 39/74 (52%), Gaps = 5/74 (6%) Query: 128 FMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY 187 F++M R+ +LQ S +T L L ++L+ + ++ H H D+K+ NLLL+ Sbjct: 132 FLLMKRYDCNLQSFLSTAP---STRTSLLLLAQLLEGVAHMTAHGIAHRDLKSDNLLLDT 188 Query: 188 KNPDQVYLV--DYG 199 P+ LV D+G Sbjct: 189 SEPESPILVISDFG 202 >4AF3-A nrPDB Length = 292 Score = 32.3 bits (72), Expect = 0.39, Method: Compositional matrix adjust. Identities = 56/246 (22%), Positives = 103/246 (41%), Gaps = 38/246 (15%) Query: 36 EWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNG---PLFTELKFYQRAAK 92 ++++G P+G+G FG +YLA S + + + K + G L E++ Sbjct: 24 DFEIGRPLGKGKFGNVYLAREKKSHFIVA-LKVLFKSQIEKEGVEHQLRREIEIQAHLHH 82 Query: 93 PE--QIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFS 150 P ++ + R+ YL + + G+ Y+ +LQK + +R + Sbjct: 83 PNILRLYNYFYDRRRIYLILE-------YAPRGELYK---------ELQKSCTFDEQRTA 126 Query: 151 RKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVH 210 T+++ + D L Y H + +H DIK NLLL K ++ D+G + VH Sbjct: 127 --TIME---ELADALMYCHGKKVIHRDIKPENLLLGLKGELKI--ADFGWS-------VH 172 Query: 211 KEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKY 270 C GT+++ + G + + DL +G + L G+ P+E + Y Sbjct: 173 APSLRRKTMC--GTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETY 230 Query: 271 VRDSKI 276 R K+ Sbjct: 231 RRIVKV 236 >3DTC-A nrPDB Length = 271 Score = 32.3 bits (72), Expect = 0.39, Method: Compositional matrix adjust. Identities = 46/201 (22%), Positives = 81/201 (40%), Gaps = 33/201 (16%) Query: 135 GSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYV---HGDIKASNLLLNYK--N 189 G L ++ + KR ++ +++I + Y+H+ V H D+K+SN+L+ K N Sbjct: 90 GGPLNRVL--SGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVEN 147 Query: 190 PDQ----VYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLE 245 D + + D+GLA +E+ K G + + + S+ D+ Sbjct: 148 GDLSNKILKITDFGLA---------REWHRTTKMSAAGAYAWMAPEVIRASMFSKGSDVW 198 Query: 246 ILGYCMIQWLTGHLPWE--DNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYM 303 G + + LTG +P+ D L V +K+ + C P AK M Sbjct: 199 SYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLAL-----PIPSTC------PEPFAKLM 247 Query: 304 ETVKLLDYTEKPLYENLRDIL 324 E D +P + N+ D L Sbjct: 248 EDCWNPDPHSRPSFTNILDQL 268 >5X3F-B nrPDB Length = 393 Score = 32.3 bits (72), Expect = 0.40, Method: Compositional matrix adjust. Identities = 18/56 (32%), Positives = 30/56 (53%), Gaps = 2/56 (3%) Query: 148 RFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYR 203 RFS + +I+ EY+H + ++ D+K NLL++ + QV D+G A R Sbjct: 180 RFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQV--TDFGFAKR 233 >3PLS-A nrPDB Length = 298 Score = 32.0 bits (71), Expect = 0.42, Method: Compositional matrix adjust. Identities = 18/65 (27%), Positives = 35/65 (53%), Gaps = 2/65 (3%) Query: 137 DLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLV 196 DL + + + + K ++ L++ +EY+ E ++VH D+ A N +L+ V + Sbjct: 109 DLLQFIRSPQRNPTVKDLISFGLQVARGMEYLAEQKFVHRDLAARNCMLD--ESFTVKVA 166 Query: 197 DYGLA 201 D+GLA Sbjct: 167 DFGLA 171 >6ED6-A nrPDB Length = 415 Score = 32.0 bits (71), Expect = 0.44, Method: Compositional matrix adjust. Identities = 68/291 (23%), Positives = 112/291 (38%), Gaps = 54/291 (18%) Query: 32 MAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEP---SDNGPLFTELKFYQ 88 M +++ V IG+G FG + L +S+ V + + K E SD+ + E Sbjct: 85 MKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYA-MKLLSKFEMIKRSDSAFFWEERDIMA 143 Query: 89 RAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIY----- 142 A P +Q + + +YL +M+M+ G DL + Sbjct: 144 FANSPWVVQLFYAFQDDRYL-------------------YMVMEYMPGGDLVNLMSNYDV 184 Query: 143 -EANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 E AK ++ + VL L+ IH +H D+K N+LL+ + L D+G Sbjct: 185 PEKWAKFYTAEVVLA--------LDAIHSMGLIHRDVKPDNMLLDKHG--HLKLADFGTC 234 Query: 202 YRYCPEG-VHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLP 260 + G VH + GT ++ S + V S+ GD G W G Sbjct: 235 MKMDETGMVHCDTAV-------GTPDYISPE----VLKSQGGD-GFYGRECDWWSVGVFL 282 Query: 261 WEDNLKDPKYVRDSKI-RYRENIASLMDKCFPEKNKPGEIAKYMETVKLLD 310 +E + D + DS + Y + + CFPE + + AK + L D Sbjct: 283 YEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTD 333 >5Z33-A nrPDB Length = 425 Score = 32.0 bits (71), Expect = 0.45, Method: Compositional matrix adjust. Identities = 17/42 (40%), Positives = 26/42 (61%), Gaps = 2/42 (4%) Query: 160 RILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 +IL L+YIH +H D+K NLL+N ++ + D+GLA Sbjct: 142 QILCGLKYIHSANVLHRDLKPGNLLVNADC--ELKICDFGLA 181 >6BDL-A nrPDB Length = 347 Score = 32.0 bits (71), Expect = 0.46, Method: Compositional matrix adjust. Identities = 33/137 (24%), Positives = 57/137 (41%), Gaps = 12/137 (8%) Query: 126 YRFMIMDR-FGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLL 184 Y +M+M+ G +L I F T + +++ Y+H ++ D+K NL+ Sbjct: 109 YLYMLMEACLGGELWTILRDRGS-FEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLI 167 Query: 185 LNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDL 244 L+++ LVD+G A + G K+ GT E+ + + D Sbjct: 168 LDHRG--YAKLVDFGFAKKI---GFGKK-----TWTFCGTPEYVAPEIILNKGHDISADY 217 Query: 245 EILGYCMIQWLTGHLPW 261 LG M + LTG P+ Sbjct: 218 WSLGILMYELLTGSPPF 234 >5SYS-A nrPDB Length = 286 Score = 32.0 bits (71), Expect = 0.46, Method: Compositional matrix adjust. Identities = 39/179 (21%), Positives = 73/179 (40%), Gaps = 34/179 (18%) Query: 32 MAKKEWKVG-------LPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTEL 84 +AK W++ + +GQG FG ++ N + V + ++P P Sbjct: 8 LAKDAWEIPRESLRLEVKLGQGCFGECWMGTWNGTTRVA-----IKTLKPGTMSPE---- 58 Query: 85 KFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF--GSDLQKIY 142 F Q A Q+ K +R KL L+ + +++ + GS L + Sbjct: 59 AFLQEA----QVMKKLRHEKL----------VQLYAVVSEEPIYIVTEYMSKGSLLDFLK 104 Query: 143 EANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 K ++ ++ +I + Y+ YVH D++A+N+L+ +V D+GLA Sbjct: 105 GEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKV--ADFGLA 161 >5DBX-A nrPDB Length = 328 Score = 32.0 bits (71), Expect = 0.47, Method: Compositional matrix adjust. Identities = 14/41 (34%), Positives = 26/41 (63%), Gaps = 2/41 (4%) Query: 161 ILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 +L+ L+Y+H + +H D+KA N+LL Q+ D+G++ Sbjct: 126 VLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQI--ADFGVS 164 >3DZO-A nrPDB Length = 413 Score = 32.0 bits (71), Expect = 0.48, Method: Compositional matrix adjust. Identities = 18/78 (23%), Positives = 38/78 (48%), Gaps = 8/78 (10%) Query: 127 RFMIMDRFGSDLQKI------YEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKA 180 RF + R S+LQ + + K LQL+L+++ +L +H + VH ++ Sbjct: 180 RFFLYPRMQSNLQTFGEVLLSHSSTHKSLVHHARLQLTLQVIRLLASLHHYGLVHTYLRP 239 Query: 181 SNLLLNYKNPDQVYLVDY 198 +++L+ + V+L + Sbjct: 240 VDIVLDQRG--GVFLTGF 255 >3ZDU-A nrPDB Length = 325 Score = 32.0 bits (71), Expect = 0.50, Method: Compositional matrix adjust. Identities = 38/148 (25%), Positives = 61/148 (41%), Gaps = 19/148 (12%) Query: 69 VVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGL-------HDK 121 V+K + + G + FY+R PEQ I R++K+L ++ L K Sbjct: 19 VMKCKHKNTGQIVAIKIFYER---PEQSVNKIAMREIKFLK--QFHHENLVNLIEVFRQK 73 Query: 122 NGKSYRFMIMDRFGSD-LQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKA 180 F +D D LQ + RK + Q IL ++Y+H + +H DIK Sbjct: 74 KKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQ----ILRAIDYLHSNNIIHRDIKP 129 Query: 181 SNLLLNYKNPDQVYLVDYGLAYRYCPEG 208 N+L++ + L D+G A G Sbjct: 130 ENILVSQSGITK--LCDFGFARTLAAPG 155 >6BFN-A nrPDB Length = 342 Score = 32.0 bits (71), Expect = 0.52, Method: Compositional matrix adjust. Identities = 43/170 (25%), Positives = 73/170 (42%), Gaps = 32/170 (18%) Query: 41 LPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWI 100 L IG+GGFGC+Y A M ++ VK + +T +K + EQ+ ++ Sbjct: 28 LKIGEGGFGCVYRAVMRNTVYA-------VKRLKENADLEWTAVK-QSFLTEVEQLSRFR 79 Query: 101 RTRKLKYLGVPKYWGSGLHDKNG---KSYRFM----IMDRFGSDLQKIYEANAKRFSRKT 153 + + +G +NG Y F+ + DR Q S Sbjct: 80 HPNIVDF--------AGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQA-----CPPLSWPQ 126 Query: 154 VLQLSLRILDILEYIHEHE--YVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 L + L ++++H+ +HGDIK+SN+LL+ + + L D+GLA Sbjct: 127 RLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPK--LGDFGLA 174 >5L6P-A nrPDB Length = 298 Score = 32.0 bits (71), Expect = 0.52, Method: Compositional matrix adjust. Identities = 27/83 (32%), Positives = 41/83 (49%), Gaps = 10/83 (12%) Query: 124 KSYRFMIMDRFGSD--LQKIYEANAKRFSRKTVLQLSLRILDI---LEYIHEHEYVHGDI 178 KS MI+ F + L N +F TV+QL + I ++Y+ E YVH D+ Sbjct: 91 KSRPVMILTEFMENCALDSFLRLNDGQF---TVIQLVGMLRGIAAGMKYLSEMNYVHRDL 147 Query: 179 KASNLLLNYKNPDQVYLVDYGLA 201 A N+L+N +V D+GL+ Sbjct: 148 AARNILVNSNLVCKVS--DFGLS 168 >3FME-A nrPDB Length = 290 Score = 32.0 bits (71), Expect = 0.53, Method: Compositional matrix adjust. Identities = 19/78 (24%), Positives = 41/78 (52%), Gaps = 6/78 (7%) Query: 128 FMIMDRFGSDLQKIYEA---NAKRFSRKTVLQLSLRILDILEYIHEH-EYVHGDIKASNL 183 ++ M+ + L K Y+ + + ++++ I+ LE++H +H D+K SN+ Sbjct: 82 WICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNV 141 Query: 184 LLNYKNPDQVYLVDYGLA 201 L+N QV + D+G++ Sbjct: 142 LINALG--QVKMCDFGIS 157 >2YCR-A nrPDB Length = 323 Score = 31.6 bits (70), Expect = 0.56, Method: Compositional matrix adjust. Identities = 16/54 (29%), Positives = 30/54 (55%), Gaps = 1/54 (1%) Query: 147 KRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPD-QVYLVDYG 199 KR T ++L ++Y+HE+ +H D+K N+LL+ + D + + D+G Sbjct: 109 KRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFG 162 >3N9X-A nrPDB Length = 432 Score = 31.6 bits (70), Expect = 0.59, Method: Compositional matrix adjust. Identities = 40/163 (24%), Positives = 76/163 (46%), Gaps = 24/163 (14%) Query: 43 IGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIR 101 IG+G +G +YLA D N+ ++V + KV +F +L +R + I ++ Sbjct: 34 IGRGSYGYVYLAYDKNTEKNVA-----IKKV-----NRMFEDLIDCKRILREITILNRLK 83 Query: 102 TR---KLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLS 158 + +L L +P D +++++ SDL+K+++ + + + + Sbjct: 84 SDYIIRLYDLIIPD-------DLLKFDELYIVLEIADSDLKKLFKT-PIFLTEEHIKTIL 135 Query: 159 LRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 +L +IHE +H D+K +N LLN V + D+GLA Sbjct: 136 YNLLLGENFIHESGIIHRDLKPANCLLNQDC--SVKVCDFGLA 176 >2JC6-A nrPDB Length = 334 Score = 31.6 bits (70), Expect = 0.59, Method: Compositional matrix adjust. Identities = 16/54 (29%), Positives = 31/54 (57%), Gaps = 1/54 (1%) Query: 149 FSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPD-QVYLVDYGLA 201 ++ K L ++LD + Y+H VH D+K NLL ++ + ++ + D+GL+ Sbjct: 117 YTEKDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLS 170 >4QNY-A nrPDB Length = 354 Score = 31.6 bits (70), Expect = 0.61, Method: Compositional matrix adjust. Identities = 21/82 (25%), Positives = 41/82 (50%), Gaps = 3/82 (3%) Query: 120 DKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIK 179 D + +++MD +DL+++ + + + + + L L IH +H DI Sbjct: 94 DPENFDHFYIVMDIMETDLKQVLRS-GQELTEAHIQFFIYQALRALHIIHSAGVIHRDIT 152 Query: 180 ASNLLLNYKNPDQVYLVDYGLA 201 +N+L+N N D + + D+GLA Sbjct: 153 PANILVN-TNCD-LKICDFGLA 172 >2W96-B nrPDB Length = 306 Score = 31.6 bits (70), Expect = 0.62, Method: Compositional matrix adjust. Identities = 21/77 (27%), Positives = 37/77 (48%), Gaps = 3/77 (3%) Query: 129 MIMDRFGSDLQKIYE-ANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY 187 ++ + DL+ + A +T+ L + L L+++H + VH D+K N+L+ Sbjct: 88 LVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTS 147 Query: 188 KNPDQVYLVDYGLAYRY 204 V L D+GLA Y Sbjct: 148 GG--TVKLADFGLARIY 162 >3OMV-A nrPDB Length = 307 Score = 31.6 bits (70), Expect = 0.62, Method: Compositional matrix adjust. Identities = 37/166 (22%), Positives = 69/166 (41%), Gaps = 37/166 (22%) Query: 43 IGQGGFGCIYLADMNSSESVGSDAPCVVKV-EPSDNGPLFTELKFYQRAAKPEQIQKW-- 99 IG G FG +Y + G A ++KV +P+ PEQ Q + Sbjct: 44 IGSGSFGTVYKGKWH-----GDVAVKILKVVDPT-----------------PEQFQAFRN 81 Query: 100 --IRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF--GSDLQKIYEANAKRFSRKTVL 155 RK +++ + + G D I+ ++ GS L K +F ++ Sbjct: 82 EVAVLRKTRHVNILLFMGYMTKDN------LAIVTQWCEGSSLYKHLHVQETKFQMFQLI 135 Query: 156 QLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 ++ + ++Y+H +H D+K++N+ L+ V + D+GLA Sbjct: 136 DIARQTAQGMDYLHAKNIIHRDMKSNNIFLH--EGLTVKIGDFGLA 179 >4KS7-A nrPDB Length = 292 Score = 31.6 bits (70), Expect = 0.63, Method: Compositional matrix adjust. Identities = 32/130 (24%), Positives = 61/130 (46%), Gaps = 13/130 (10%) Query: 148 RFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPE 207 R + + + + +L L Y+H +H DIK+ ++LL +V L D+G +C + Sbjct: 115 RLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDG--RVKLSDFG----FCAQ 168 Query: 208 GVHKEYKEDPKR-CHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPW--EDN 264 K+ PKR GT + + + + + D+ LG +I+ + G P+ + Sbjct: 169 I----SKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSP 224 Query: 265 LKDPKYVRDS 274 ++ K +RDS Sbjct: 225 VQAMKRLRDS 234 >4IX6-A nrPDB Length = 350 Score = 31.6 bits (70), Expect = 0.69, Method: Compositional matrix adjust. Identities = 16/46 (34%), Positives = 24/46 (52%) Query: 161 ILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCP 206 +L L +HE VH D+K +NL+ K+ + L+D G A P Sbjct: 152 LLGSLARLHECGVVHRDVKPANLIAAEKDGGVLKLIDLGAAALCLP 197 >3UC3-A nrPDB Length = 361 Score = 31.6 bits (70), Expect = 0.69, Method: Compositional matrix adjust. Identities = 18/62 (29%), Positives = 30/62 (48%), Gaps = 2/62 (3%) Query: 140 KIYE--ANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVD 197 ++YE NA RFS ++L + Y H + H D+K N LL+ ++ + D Sbjct: 102 ELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICD 161 Query: 198 YG 199 +G Sbjct: 162 FG 163 >4HVI-A nrPDB Length = 314 Score = 31.2 bits (69), Expect = 0.78, Method: Compositional matrix adjust. Identities = 41/161 (25%), Positives = 74/161 (45%), Gaps = 19/161 (11%) Query: 43 IGQGGFGCIYLADMNSSESVGSDAPCVVKV-EPSDNGPLFTELKFYQRAAKPEQIQKWIR 101 +G+G FG + L + +G + +V V + +GP + + +QR QI K + Sbjct: 18 LGKGNFGSVELCRYDP---LGDNTGALVAVKQLQHSGP--DQQRDFQREI---QILKALH 69 Query: 102 TRKL-KYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLR 160 + + KY GV +G G +S R ++ L+ + + R +L S + Sbjct: 70 SDFIVKYRGVS--YGPG-----RQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQ 122 Query: 161 ILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 I +EY+ VH D+ A N+L+ ++ V + D+GLA Sbjct: 123 ICKGMEYLGSRRCVHRDLAARNILV--ESEAHVKIADFGLA 161 >6EII-A nrPDB Length = 352 Score = 31.2 bits (69), Expect = 0.78, Method: Compositional matrix adjust. Identities = 16/46 (34%), Positives = 30/46 (65%), Gaps = 1/46 (2%) Query: 161 ILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCP 206 IL L+Y H +H D+K N+++++++ ++ L+D+GLA Y P Sbjct: 163 ILKALDYCHSMGIMHRDVKPHNVMIDHEHR-KLRLIDWGLAEFYHP 207 >3I6U-A nrPDB Length = 419 Score = 31.2 bits (69), Expect = 0.80, Method: Compositional matrix adjust. Identities = 16/54 (29%), Positives = 30/54 (55%), Gaps = 1/54 (1%) Query: 147 KRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPD-QVYLVDYG 199 KR T ++L ++Y+HE+ +H D+K N+LL+ + D + + D+G Sbjct: 234 KRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFG 287 >2VWV-A nrPDB Length = 302 Score = 31.2 bits (69), Expect = 0.80, Method: Compositional matrix adjust. Identities = 22/80 (27%), Positives = 37/80 (46%), Gaps = 4/80 (5%) Query: 124 KSYRFMIMDRFGSD--LQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKAS 181 S MI+ F + L N +F+ ++ + I + Y+ E YVH D+ A Sbjct: 88 NSMPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGMRYLAEMSYVHRDLAAR 147 Query: 182 NLLLNYKNPDQVYLVDYGLA 201 N+L+N +V D+GL+ Sbjct: 148 NILVNSNLVCKVS--DFGLS 165 >5MJB-A nrPDB Length = 305 Score = 31.2 bits (69), Expect = 0.84, Method: Compositional matrix adjust. Identities = 29/86 (33%), Positives = 43/86 (50%), Gaps = 11/86 (12%) Query: 124 KSYRFMIMDRFGSD--LQKIYEANAKRFSRKTVLQLSLRILDI---LEYIHEHEYVHGDI 178 KS MI+ F + L N +F TV+QL + I ++Y+ E YVH D+ Sbjct: 98 KSRPVMIITEFMENCALDSFLRQNDGQF---TVIQLVGMLRGIAAGMKYLSEMNYVHRDL 154 Query: 179 KASNLLLNYKNPDQVYLVDYGLAYRY 204 A N+L+N +V D+GL+ RY Sbjct: 155 AARNILVNSNLVCKVS--DFGLS-RY 177 >4CI6-B nrPDB Length = 643 Score = 31.2 bits (69), Expect = 0.85, Method: Compositional matrix adjust. Identities = 18/64 (28%), Positives = 36/64 (56%), Gaps = 3/64 (4%) Query: 153 TVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYC--PEGVH 210 T+ ++ R+LD+ ++ + VH DIK N++ + + + V ++D GL R P+G Sbjct: 157 TIKFIAHRLLDVTNHLAKAGIVHNDIKPGNVVFDRASGEPV-VIDLGLHSRSGEQPKGFT 215 Query: 211 KEYK 214 + +K Sbjct: 216 ESFK 219 >6HMD-A nrPDB Length = 365 Score = 31.2 bits (69), Expect = 0.86, Method: Compositional matrix adjust. Identities = 15/46 (32%), Positives = 29/46 (63%), Gaps = 1/46 (2%) Query: 161 ILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCP 206 +L L+Y H +H D+K N++++++ ++ L+D+GLA Y P Sbjct: 156 LLKALDYCHSKGIMHRDVKPHNVMIDHQQ-KKLRLIDWGLAEFYHP 200 >6HXF-B nrPDB Length = 302 Score = 31.2 bits (69), Expect = 0.89, Method: Compositional matrix adjust. Identities = 34/169 (20%), Positives = 68/169 (40%), Gaps = 25/169 (14%) Query: 37 WKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQI 96 W++ +G G FG +Y A + ++ + K E + E++ P + Sbjct: 21 WEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSE-EELEDYIVEIEILATCDHPYIV 79 Query: 97 QKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF--GSDLQKIYEANAKRFSRKTV 154 K G+ HD GK + IM F G + I + + + Sbjct: 80 ---------------KLLGAYYHD--GKLW---IMIEFCPGGAVDAIMLELDRGLTEPQI 119 Query: 155 LQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYR 203 + ++L+ L ++H +H D+KA N+L+ + + L D+G++ + Sbjct: 120 QVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEG--DIRLADFGVSAK 166 >1N8P-A nrPDB Length = 393 Score = 31.2 bits (69), Expect = 0.89, Method: Compositional matrix adjust. Identities = 16/43 (37%), Positives = 22/43 (51%), Gaps = 2/43 (4%) Query: 68 CVVKVEPSDNGPLFTELKFYQRA--AKPEQIQKWIRTRKLKYL 108 V+ V ++N PL+ L+F Q A A P W+ R LK L Sbjct: 211 VVLGVLATNNKPLYERLQFLQNAIGAIPSPFDAWLTHRGLKTL 253 >3VHK-A nrPDB Length = 368 Score = 31.2 bits (69), Expect = 0.92, Method: Compositional matrix adjust. Identities = 15/44 (34%), Positives = 27/44 (61%), Gaps = 2/44 (4%) Query: 158 SLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 S ++ +E++ + +H D+ A N+LL+ KN V + D+GLA Sbjct: 206 SFQVAKGMEFLASRKCIHRDLAARNILLSEKN--VVKICDFGLA 247 >5WAX-A nrPDB Length = 310 Score = 30.8 bits (68), Expect = 0.95, Method: Compositional matrix adjust. Identities = 15/56 (26%), Positives = 26/56 (46%) Query: 144 ANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYG 199 NA RFS +++ + Y H + H D+K N LL+ ++ + D+G Sbjct: 99 CNAGRFSEDEARFFFQQLISGVSYCHSMQVCHRDLKLENTLLDGSTAPRLKICDFG 154 >3GQL-A nrPDB Length = 326 Score = 30.8 bits (68), Expect = 0.96, Method: Compositional matrix adjust. Identities = 40/180 (22%), Positives = 77/180 (42%), Gaps = 31/180 (17%) Query: 39 VGLPIGQGGFGCIYLADMNSSESVGSD-------APCVVKVEPSDN-----GPLFTELKF 86 +G P+G+G FG + LA E++G D VK+ SD L +E++ Sbjct: 32 LGKPLGEGAFGQVVLA-----EAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEM 86 Query: 87 YQRAAKPEQIQKWIR--TRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEA 144 + K + I + T+ + +Y G + R + R L+ Y Sbjct: 87 MKMIGKHKNIINLLGACTQDGPLYVIVEYASKG-------NLREYLQARRPPGLEYCYNP 139 Query: 145 N---AKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 + ++ S K ++ + ++ +EY+ + +H D+ A N+L+ N + + D+GLA Sbjct: 140 SHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDN--VMKIADFGLA 197 >5VE6-A nrPDB Length = 492 Score = 30.8 bits (68), Expect = 0.97, Method: Compositional matrix adjust. Identities = 16/52 (30%), Positives = 28/52 (53%), Gaps = 1/52 (1%) Query: 134 FGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLL 185 F D ++A + + R+ L L++ + LE++ EH +H D+ NLLL Sbjct: 191 FVRDSAASHQAEPEAYERRVCFLL-LQLCNGLEHLKEHGIIHRDLCLENLLL 241 >5VDK-A nrPDB Length = 297 Score = 30.8 bits (68), Expect = 0.98, Method: Compositional matrix adjust. Identities = 20/57 (35%), Positives = 26/57 (45%), Gaps = 3/57 (5%) Query: 135 GSDLQKIYEANAK---RFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYK 188 G LQ N K F + + L+I L YIH VH DIK SN+ + +K Sbjct: 99 GGSLQAAISENTKSGNHFEEPKLKDILLQISLGLNYIHNSSMVHLDIKPSNIFICHK 155 >5N23-A nrPDB Length = 352 Score = 30.8 bits (68), Expect = 0.99, Method: Compositional matrix adjust. Identities = 16/56 (28%), Positives = 30/56 (53%), Gaps = 2/56 (3%) Query: 148 RFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYR 203 RFS + +I+ EY+H + ++ D+K NLL++ + + + D+G A R Sbjct: 138 RFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQG--YIKVADFGFAKR 191 >4NEU-A nrPDB Length = 333 Score = 30.8 bits (68), Expect = 0.99, Method: Compositional matrix adjust. Identities = 35/156 (22%), Positives = 69/156 (44%), Gaps = 23/156 (14%) Query: 161 ILDILE---YIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA----YRYCPEGVHKEY 213 IL+I+E Y+H +H D+K N+L++ N + + D GLA + H E Sbjct: 128 ILEIIEGMCYLHGKGVIHKDLKPENILVD--NDFHIKIADLGLASFKMWSKLNNEEHNEL 185 Query: 214 KE--DPKRCHDGTIEFTSIDAHNGV--APSRRGDLEILGYCMIQW--LTGHLPWEDNLKD 267 +E + + GT+ + + + N V P+ + D + + ++ W P+E+ + + Sbjct: 186 REVDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSD--VYSFAVVLWAIFANKEPYENAICE 243 Query: 268 PKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYM 303 + + K R ++ + + C P EI M Sbjct: 244 QQLIMCIKSGNRPDVDDITEYC------PREIISLM 273 >3BYV-A nrPDB Length = 377 Score = 30.8 bits (68), Expect = 1.00, Method: Compositional matrix adjust. Identities = 16/68 (23%), Positives = 34/68 (50%), Gaps = 6/68 (8%) Query: 127 RFMIMDRFGSDLQKI------YEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKA 180 RF + R S+LQ + + K LQL+L+++ +L +H + VH ++ Sbjct: 175 RFFLYPRMQSNLQTFGEVLLSHSSTHKSLVHHARLQLTLQVIRLLASLHHYGLVHTYLRP 234 Query: 181 SNLLLNYK 188 +++L+ + Sbjct: 235 VDIVLDQR 242 >5AKB-A nrPDB Length = 800 Score = 30.8 bits (68), Expect = 1.0, Method: Compositional matrix adjust. Identities = 22/72 (30%), Positives = 35/72 (48%), Gaps = 3/72 (4%) Query: 313 EKPLYENLRDILLQGLKAIGSKDDGKLDLSVVENGGLKAKTITKKRKKEIEESKEPGVED 372 EK LYE L D+LL L+A+ +L V+ N +A T+ I+ +PG+ Sbjct: 524 EKQLYEELFDLLLPHLEALQQSASALAELDVLVNLAERAYTLNYTSPTFID---KPGIRI 580 Query: 373 TEWSNTQTEEAI 384 TE + E+ + Sbjct: 581 TEGRHPVVEQVL 592 >4EBW-A nrPDB Length = 304 Score = 30.8 bits (68), Expect = 1.0, Method: Compositional matrix adjust. Identities = 32/111 (28%), Positives = 53/111 (47%), Gaps = 14/111 (12%) Query: 151 RKTVLQLSLRIL------DILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRY 204 RK L L+ IL L Y+ +VH DI A N+L++ + D V L D+GL+ RY Sbjct: 132 RKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVS--SNDCVKLGDFGLS-RY 188 Query: 205 CPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWL 255 + + YK + I++ + ++ N + D+ + G CM + L Sbjct: 189 MEDSTY--YKASKGKL---PIKWMAPESINFRRFTSASDVWMFGVCMWEIL 234 >2VN9-A nrPDB Length = 301 Score = 30.8 bits (68), Expect = 1.0, Method: Compositional matrix adjust. Identities = 18/43 (41%), Positives = 26/43 (60%), Gaps = 1/43 (2%) Query: 160 RILDILEYIHEHEYVHGDIKASNLLLNYKNPD-QVYLVDYGLA 201 +IL+ + + H + VH D+K NLLL K+ V L D+GLA Sbjct: 111 QILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLA 153 >5HLW-A nrPDB Length = 299 Score = 30.8 bits (68), Expect = 1.0, Method: Compositional matrix adjust. Identities = 35/159 (22%), Positives = 63/159 (39%), Gaps = 16/159 (10%) Query: 43 IGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRT 102 IG+G FGC+Y + ++ G C VK S N + + + + I Sbjct: 28 IGRGHFGCVYHGTLLDND--GKKIHCAVK---SLN-------RITDIGEVSQFLTEGIIM 75 Query: 103 RKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRIL 162 + + V G L + M DL+ + K ++ L++ Sbjct: 76 KDFSHPNVLSLLGICLRSEGSPLVVLPYMKH--GDLRNFIRNETHNPTVKDLIGFGLQVA 133 Query: 163 DILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 ++Y+ ++VH D+ A N +L+ K V + D+GLA Sbjct: 134 KGMKYLASKKFVHRDLAARNCMLDEKF--TVKVADFGLA 170 >3TAC-A nrPDB Length = 361 Score = 30.8 bits (68), Expect = 1.0, Method: Compositional matrix adjust. Identities = 27/86 (31%), Positives = 43/86 (50%), Gaps = 6/86 (6%) Query: 128 FMIMDRFGSDL--QKIYEANAKRFSRKTVLQLSLR-ILDILEYIHEHEYVHGDIKASNLL 184 F MD G+DL + + A+A + V +R IL+ L Y H++ +H D+K +L Sbjct: 107 FEFMD--GADLCFEIVKRADAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKPHCVL 164 Query: 185 LNYK-NPDQVYLVDYGLAYRYCPEGV 209 L K N V L +G+A + G+ Sbjct: 165 LASKENSAPVKLGGFGVAIQLGESGL 190 >2J0K-A nrPDB Length = 656 Score = 30.8 bits (68), Expect = 1.1, Method: Compositional matrix adjust. Identities = 32/111 (28%), Positives = 52/111 (46%), Gaps = 14/111 (12%) Query: 151 RKTVLQLSLRIL------DILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRY 204 RK L L+ IL L Y+ +VH DI A N+L++ D V L D+GL+ RY Sbjct: 484 RKFSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSAT--DCVKLGDFGLS-RY 540 Query: 205 CPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWL 255 + + YK + I++ + ++ N + D+ + G CM + L Sbjct: 541 MEDSTY--YKASKGKL---PIKWMAPESINFRRFTSASDVWMFGVCMWEIL 586 >5U6Y-A nrPDB Length = 461 Score = 30.8 bits (68), Expect = 1.1, Method: Compositional matrix adjust. Identities = 18/43 (41%), Positives = 25/43 (58%), Gaps = 1/43 (2%) Query: 160 RILDILEYIHEHEYVHGDIKASNLLLNYK-NPDQVYLVDYGLA 201 +IL+ + + H+ VH D+K NLLL K V L D+GLA Sbjct: 107 QILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLA 149 >5M07-A nrPDB Length = 276 Score = 30.8 bits (68), Expect = 1.1, Method: Compositional matrix adjust. Identities = 15/50 (30%), Positives = 29/50 (58%), Gaps = 2/50 (4%) Query: 154 VLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNP-DQ-VYLVDYGLA 201 VL + + L+Y H+ +H D+ +N++L ++ DQ + L D+G+A Sbjct: 134 VLAIVTAVAGALDYAHQRGLLHRDVNPANVVLTSQSAGDQRILLADFGIA 183 >5X1R-A nrPDB Length = 302 Score = 30.8 bits (68), Expect = 1.1, Method: Compositional matrix adjust. Identities = 38/189 (20%), Positives = 70/189 (37%), Gaps = 44/189 (23%) Query: 35 KEWKVGLPIGQGGFGCIY--------------------LADMNSSESVGSDAPCVVKVEP 74 E+++ IG+GGFG +Y LA N S+G K Sbjct: 21 NEFEIQEAIGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAKRNDDLSIGLRGERFGKTFQ 80 Query: 75 SDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF 134 + E + R + P L V ++W ++NG +Y + +F Sbjct: 81 AGLNSFIQEARLLARFSHP------------GLLHVLRFW-----EENGTAY---MGTQF 120 Query: 135 --GSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQ 192 G+ L+ + ++ + +L + + IH+ Y+H DI N+ + + Sbjct: 121 YSGTTLKNLQAQQPEKIDEAWIRRLLPPLFSAINTIHQEGYLHRDISLDNIQI--QESQL 178 Query: 193 VYLVDYGLA 201 L+D+G A Sbjct: 179 PVLLDFGSA 187 >3BHH-A nrPDB Length = 295 Score = 30.8 bits (68), Expect = 1.1, Method: Compositional matrix adjust. Identities = 25/88 (28%), Positives = 42/88 (47%), Gaps = 6/88 (6%) Query: 118 LHDK-NGKSYRFMIMDRFGSDLQKIYEANAKR--FSRKTVLQLSLRILDILEYIHEHEYV 174 LHD + + + +++ D +++E R +S +IL+ + + H+ V Sbjct: 68 LHDSISEEGFHYLVFDLVTGG--ELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVV 125 Query: 175 HGDIKASNLLLNYK-NPDQVYLVDYGLA 201 H D+K NLLL K V L D+GLA Sbjct: 126 HRDLKPENLLLASKCKGAAVKLADFGLA 153 >5KZ7-A nrPDB Length = 346 Score = 30.8 bits (68), Expect = 1.2, Method: Compositional matrix adjust. Identities = 39/166 (23%), Positives = 71/166 (42%), Gaps = 26/166 (15%) Query: 43 IGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKW-- 99 IG+G F + LA + + + V ++ S LF E++ + P ++ + Sbjct: 41 IGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEV 100 Query: 100 IRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSL 159 I T K YL + + SG G+ + +++ K EA AK Sbjct: 101 IETEKTLYLVME--YASG-----GEVFDYLV----AHGRMKEKEARAK----------FR 139 Query: 160 RILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYC 205 +I+ ++Y H+ VH D+KA NLLL+ + + D+G + + Sbjct: 140 QIVSAVQYCHQKFIVHRDLKAENLLLDADM--NIKIADFGFSNEFT 183 >3A4O-X nrPDB Length = 286 Score = 30.8 bits (68), Expect = 1.2, Method: Compositional matrix adjust. Identities = 14/48 (29%), Positives = 28/48 (58%), Gaps = 2/48 (4%) Query: 154 VLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 ++ S +I + + YI Y+H D++A+N+L++ + D+GLA Sbjct: 112 LIDFSAQIAEGMAYIERKNYIHRDLRAANVLVS--ESLMCKIADFGLA 157 >2WTK-B nrPDB Length = 373 Score = 30.8 bits (68), Expect = 1.2, Method: Compositional matrix adjust. Identities = 25/105 (23%), Positives = 45/105 (42%), Gaps = 4/105 (3%) Query: 161 ILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRC 220 +L L+YIH YVH +KAS++L++ +VYL G + D + Sbjct: 121 VLKALDYIHHMGYVHRSVKASHILISVDG--KVYLSGLRSNLSMISHGQRQRVVHDFPKY 178 Query: 221 HDGTIEFTS--IDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWED 263 + + S + N + D+ +G + GH+P++D Sbjct: 179 SVKVLPWLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKD 223 >2BUJ-A nrPDB Length = 317 Score = 30.4 bits (67), Expect = 1.3, Method: Compositional matrix adjust. Identities = 20/57 (35%), Positives = 28/57 (49%), Gaps = 2/57 (3%) Query: 149 FSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYC 205 + +L L L I LE IH Y H D+K +N+LL + Q L+D G + C Sbjct: 131 LTEDQILWLLLGICRGLEAIHAKGYAHRDLKPTNILLG--DEGQPVLMDLGSMNQAC 185 >5HIE-A nrPDB Length = 302 Score = 30.4 bits (67), Expect = 1.3, Method: Compositional matrix adjust. Identities = 44/233 (18%), Positives = 86/233 (36%), Gaps = 46/233 (19%) Query: 39 VGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPL-----FTELKFYQRAAKP 93 VG IG G FG +Y + +V P ++ ++ G L L F + KP Sbjct: 40 VGQRIGSGSFGTVYKGKWHGDVAVKMLTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKP 99 Query: 94 EQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKT 153 + L + W G S L +F Sbjct: 100 Q-------------LAIVTQWCEG------------------SSLYHHLHIIETKFEMIK 128 Query: 154 VLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEY 213 ++ ++ + ++Y+H +H D+K++N+ L+ V + D+GLA ++ Sbjct: 129 LIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLH--EDLTVKIGDFGLATVKSRWSGSHQF 186 Query: 214 KEDPKRCHDGTIEFTS---IDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWED 263 ++ G+I + + I + S + D+ G + + +TG LP+ + Sbjct: 187 EQ-----LSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSN 234 >4X3F-A nrPDB Length = 337 Score = 30.4 bits (67), Expect = 1.3, Method: Compositional matrix adjust. Identities = 28/115 (24%), Positives = 50/115 (43%), Gaps = 9/115 (7%) Query: 93 PEQIQKWI----RTRKLKYLGVPKYWGSGLHDKNGKS-YRFMIMDRF-GSDLQKIYEANA 146 PE I+++ T L + G+ G NG+ +++M+ G L + + Sbjct: 53 PEFIERFRAEARTTAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLK-RT 111 Query: 147 KRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 R S + L + + L+ H VH D+K N+L+ QV + D+G+A Sbjct: 112 GRLSLRHALDMLEQTGRALQIAHAAGLVHRDVKPGNILITPTG--QVKITDFGIA 164 >3CJF-A nrPDB Length = 309 Score = 30.4 bits (67), Expect = 1.3, Method: Compositional matrix adjust. Identities = 15/44 (34%), Positives = 27/44 (61%), Gaps = 2/44 (4%) Query: 158 SLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 S ++ +E++ + +H D+ A N+LL+ KN V + D+GLA Sbjct: 150 SFQVAKGMEFLASRKCIHRDLAARNILLSEKN--VVKICDFGLA 191 >3HNG-A nrPDB Length = 360 Score = 30.4 bits (67), Expect = 1.3, Method: Compositional matrix adjust. Identities = 14/48 (29%), Positives = 28/48 (58%), Gaps = 2/48 (4%) Query: 154 VLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 ++ S ++ +E++ + +H D+ A N+LL+ N V + D+GLA Sbjct: 201 LISYSFQVARGMEFLSSRKCIHRDLAARNILLSENN--VVKICDFGLA 246 >2VZ6-A nrPDB Length = 313 Score = 30.4 bits (67), Expect = 1.4, Method: Compositional matrix adjust. Identities = 18/43 (41%), Positives = 25/43 (58%), Gaps = 1/43 (2%) Query: 160 RILDILEYIHEHEYVHGDIKASNLLLNYK-NPDQVYLVDYGLA 201 +IL+ + + H+ VH D+K NLLL K V L D+GLA Sbjct: 129 QILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLA 171 >5T88-A nrPDB Length = 616 Score = 30.4 bits (67), Expect = 1.4, Method: Compositional matrix adjust. Identities = 15/35 (42%), Positives = 20/35 (57%), Gaps = 3/35 (8%) Query: 261 WEDNLKDP---KYVRDSKIRYRENIASLMDKCFPE 292 W +NL+D K + + R+RE I L DK FPE Sbjct: 7 WMENLEDERVLKIIEEENKRFREFIGELSDKLFPE 41 >2W1Z-A nrPDB Length = 368 Score = 30.4 bits (67), Expect = 1.5, Method: Compositional matrix adjust. Identities = 16/68 (23%), Positives = 32/68 (47%), Gaps = 6/68 (8%) Query: 127 RFMIMDRFGSDLQKI------YEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKA 180 RF + R S+L + + + K LQL+L+++ + + + VH D + Sbjct: 160 RFFLYPRMQSNLHILGDVLLSHSSTHKSLVHHARLQLTLQLIRLAASLQHYGLVHADFQV 219 Query: 181 SNLLLNYK 188 N+LL+ + Sbjct: 220 RNILLDQR 227 >4HZS-A nrPDB Length = 341 Score = 30.4 bits (67), Expect = 1.5, Method: Compositional matrix adjust. Identities = 23/88 (26%), Positives = 46/88 (52%), Gaps = 8/88 (9%) Query: 134 FGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQV 193 GS L ++ + F T+ + ++++ + + Y+ ++H D+ A NLLL + D V Sbjct: 98 LGSLLDRLRKHQG-HFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATR--DLV 154 Query: 194 YLVDYGLAYRYCPEG----VHKEYKEDP 217 + D+GL R P+ V +E+++ P Sbjct: 155 KIGDFGL-MRALPQNDDHYVMQEHRKVP 181 >1U54-B nrPDB Length = 291 Score = 30.4 bits (67), Expect = 1.5, Method: Compositional matrix adjust. Identities = 23/88 (26%), Positives = 46/88 (52%), Gaps = 8/88 (9%) Query: 134 FGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQV 193 GS L ++ + F T+ + ++++ + + Y+ ++H D+ A NLLL + D V Sbjct: 104 LGSLLDRLRKHQG-HFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATR--DLV 160 Query: 194 YLVDYGLAYRYCPEG----VHKEYKEDP 217 + D+GL R P+ V +E+++ P Sbjct: 161 KIGDFGL-MRALPQNDDHYVMQEHRKVP 187 >2F9G-A nrPDB Length = 353 Score = 30.4 bits (67), Expect = 1.6, Method: Compositional matrix adjust. Identities = 20/74 (27%), Positives = 39/74 (52%), Gaps = 4/74 (5%) Query: 128 FMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY 187 ++I + +DL ++ + + S + + L ++ +H +H D+K SNLL+N Sbjct: 90 YIIQELMQTDLHRV--ISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLIN- 146 Query: 188 KNPDQVYLVDYGLA 201 N D + + D+GLA Sbjct: 147 SNCD-LKVCDFGLA 159 >5YV8-A nrPDB Length = 298 Score = 30.4 bits (67), Expect = 1.6, Method: Compositional matrix adjust. Identities = 13/40 (32%), Positives = 24/40 (60%), Gaps = 2/40 (5%) Query: 165 LEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRY 204 +EY+H + +H DIK SNLL+ + + D+G++ + Sbjct: 150 IEYLHYQKIIHRDIKPSNLLVGEDG--HIKIADFGVSNEF 187 >5A46-A nrPDB Length = 386 Score = 30.4 bits (67), Expect = 1.6, Method: Compositional matrix adjust. Identities = 40/188 (21%), Positives = 80/188 (42%), Gaps = 31/188 (16%) Query: 31 DMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSD-------APCVVKVEPSDN-----G 78 ++ + +G P+G+G FG + LA E++G D VK+ SD Sbjct: 36 ELPRDRLVLGKPLGEGCFGQVVLA-----EAIGLDKDKPNRVTKVAVKMLKSDATEKDLS 90 Query: 79 PLFTELKFYQRAAKPEQIQKWIR--TRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGS 136 L +E++ + K + I + T+ + +Y G + R + R Sbjct: 91 DLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKG-------NLREYLQARRPP 143 Query: 137 DLQKIYEAN---AKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQV 193 L+ Y + ++ S K ++ + ++ +EY+ + +H D+ A N+L+ N + Sbjct: 144 GLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDN--VM 201 Query: 194 YLVDYGLA 201 + D+GLA Sbjct: 202 KIADFGLA 209 >2DQ7-X nrPDB Length = 283 Score = 30.0 bits (66), Expect = 1.6, Method: Compositional matrix adjust. Identities = 15/67 (22%), Positives = 34/67 (50%), Gaps = 2/67 (2%) Query: 135 GSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVY 194 GS L + + + ++ ++ ++ + YI Y+H D++++N+L+ N Sbjct: 88 GSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVG--NGLICK 145 Query: 195 LVDYGLA 201 + D+GLA Sbjct: 146 IADFGLA 152 >3QD2-B nrPDB Length = 332 Score = 30.0 bits (66), Expect = 1.6, Method: Compositional matrix adjust. Identities = 14/49 (28%), Positives = 26/49 (53%), Gaps = 2/49 (4%) Query: 153 TVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 L + ++I + +E++H +H D+K SN+ D V + D+GL Sbjct: 165 VCLHIFIQIAEAVEFLHSKGLMHRDLKPSNIFFTMD--DVVKVGDFGLV 211 >4OW8-A nrPDB Length = 283 Score = 30.0 bits (66), Expect = 1.6, Method: Compositional matrix adjust. Identities = 28/118 (23%), Positives = 52/118 (44%), Gaps = 9/118 (7%) Query: 90 AAKPEQIQKWI----RTRKLKYLGVPKYWGSGLHDKNGKS-YRFMIMDRF-GSDLQKIYE 143 ++ PE I+++ T L + G+ G NG+ +++M+ G L + + Sbjct: 49 SSDPEFIERFRAEARTTAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLK 108 Query: 144 ANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 R S + L + + L+ H VH D+K N+L+ QV + D+G+A Sbjct: 109 -RTGRLSLRHALDMLEQTGRALQIAHAAGLVHRDVKPGNILITPTG--QVKITDFGIA 163 >2PVN-A nrPDB Length = 352 Score = 30.0 bits (66), Expect = 1.7, Method: Compositional matrix adjust. Identities = 15/46 (32%), Positives = 29/46 (63%), Gaps = 1/46 (2%) Query: 161 ILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCP 206 +L L+Y H +H D+K N++++++ ++ L+D+GLA Y P Sbjct: 155 LLKALDYCHSQGIMHRDVKPHNVMIDHE-LRKLRLIDWGLAEFYHP 199 >1JPA-A nrPDB Length = 312 Score = 30.0 bits (66), Expect = 1.7, Method: Compositional matrix adjust. Identities = 22/80 (27%), Positives = 38/80 (47%), Gaps = 4/80 (5%) Query: 124 KSYRFMIMDRF--GSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKAS 181 KS MI+ F L N +F+ ++ + I ++Y+ + YVH D+ A Sbjct: 105 KSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAAR 164 Query: 182 NLLLNYKNPDQVYLVDYGLA 201 N+L+N +V D+GL+ Sbjct: 165 NILVNSNLVCKVS--DFGLS 182 >3UIM-A nrPDB Length = 326 Score = 30.0 bits (66), Expect = 1.7, Method: Compositional matrix adjust. Identities = 15/40 (37%), Positives = 27/40 (67%), Gaps = 5/40 (12%) Query: 165 LEYIHEH---EYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 L Y+H+H + +H D+KA+N+LL+ + + + D+GLA Sbjct: 144 LAYLHDHCDPKIIHRDVKAANILLDEEF--EAVVGDFGLA 181 >5XD6-A nrPDB Length = 305 Score = 30.0 bits (66), Expect = 1.7, Method: Compositional matrix adjust. Identities = 28/108 (25%), Positives = 47/108 (43%), Gaps = 18/108 (16%) Query: 165 LEYIHEH---EYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCH 221 LEY+HE +H DIK+SN+LL + D + D+ L+ + + R H Sbjct: 139 LEYLHEKANPHVIHRDIKSSNVLLF--DDDVAKIADFDLS---------NQAPDMAARLH 187 Query: 222 D----GTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNL 265 GT + + + S + D+ G +++ LTG P + L Sbjct: 188 STRVLGTFGYHAPEYAMTGTLSTKSDVYSFGVVLLELLTGRKPVDHTL 235 >3GC0-A nrPDB Length = 329 Score = 30.0 bits (66), Expect = 1.7, Method: Compositional matrix adjust. Identities = 18/79 (22%), Positives = 40/79 (50%), Gaps = 4/79 (5%) Query: 129 MIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYK 188 +I + +DL+K + N S + + ++++ + + H +H D+K NLLL+ Sbjct: 110 LIFEYAENDLKKYMDKNPD-VSMRVIKSFLYQLINGVNFCHSRRCLHRDLKPQNLLLSVS 168 Query: 189 NPDQVYLV---DYGLAYRY 204 + + ++ D+GLA + Sbjct: 169 DASETPVLKIGDFGLARAF 187 >3C1X-A nrPDB Length = 373 Score = 30.0 bits (66), Expect = 1.8, Method: Compositional matrix adjust. Identities = 34/159 (21%), Positives = 63/159 (39%), Gaps = 16/159 (10%) Query: 43 IGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRT 102 IG+G FGC+Y + ++ G C VK S N + + + + I Sbjct: 97 IGRGHFGCVYHGTLLDND--GKKIHCAVK---SLN-------RITDIGEVSQFLTEGIIM 144 Query: 103 RKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRIL 162 + + V G L + M DL+ + K ++ L++ Sbjct: 145 KDFSHPNVLSLLGICLRSEGSPLVVLPYMKH--GDLRNFIRNETHNPTVKDLIGFGLQVA 202 Query: 163 DILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 ++++ ++VH D+ A N +L+ K V + D+GLA Sbjct: 203 KGMKFLASKKFVHRDLAARNCMLDEKF--TVKVADFGLA 239 >6G4J-A nrPDB Length = 315 Score = 30.0 bits (66), Expect = 1.9, Method: Compositional matrix adjust. Identities = 12/43 (27%), Positives = 25/43 (58%), Gaps = 1/43 (2%) Query: 157 LSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYG 199 L +++L L +H+ ++ GD+K NL++ P ++ +D G Sbjct: 128 LMIQLLSSLSVLHQQGWIFGDLKPDNLIVT-GPPARIRCIDVG 169 >4BBM-A nrPDB Length = 331 Score = 30.0 bits (66), Expect = 1.9, Method: Compositional matrix adjust. Identities = 15/50 (30%), Positives = 27/50 (54%), Gaps = 2/50 (4%) Query: 152 KTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 + V + +I++ + + H H +H DIK N+L++ V L D+G A Sbjct: 124 QVVQKYLFQIINGIGFCHSHNIIHRDIKPENILVS--QSGVVKLCDFGFA 171 >3NYO-A nrPDB Length = 576 Score = 30.0 bits (66), Expect = 1.9, Method: Compositional matrix adjust. Identities = 23/75 (30%), Positives = 35/75 (46%), Gaps = 4/75 (5%) Query: 135 GSDLQ-KIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQV 193 G DL+ IY F + + I LE +H V+ D+K N+LL+ + + Sbjct: 268 GGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLD--DHGHI 325 Query: 194 YLVDYGLAYRYCPEG 208 + D GLA + PEG Sbjct: 326 RISDLGLAV-HVPEG 339 >6CMJ-A nrPDB Length = 321 Score = 30.0 bits (66), Expect = 1.9, Method: Compositional matrix adjust. Identities = 13/40 (32%), Positives = 24/40 (60%), Gaps = 2/40 (5%) Query: 165 LEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRY 204 +EY+H + +H DIK SNLL+ + + D+G++ + Sbjct: 156 IEYLHYQKIIHRDIKPSNLLVGEDG--HIKIADFGVSNEF 193 >3C51-A nrPDB Length = 543 Score = 30.0 bits (66), Expect = 2.0, Method: Compositional matrix adjust. Identities = 36/162 (22%), Positives = 67/162 (41%), Gaps = 21/162 (12%) Query: 43 IGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRT 102 +G+GGFG ++ M ++ + + K G YQ A ++I + + Sbjct: 193 LGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKG--------YQGAMVEKKILAKVHS 244 Query: 103 RKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQ-KIYEANAKR--FSRKTVLQLSL 159 R + L K IM+ G D++ IY + F + + Sbjct: 245 RFIVSLAY------AFETKTDLCLVMTIMN--GGDIRYHIYNVDEDNPGFQEPRAIFYTA 296 Query: 160 RILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 +I+ LE++H+ ++ D+K N+LL+ + V + D GLA Sbjct: 297 QIVSGLEHLHQRNIIYRDLKPENVLLD--DDGNVRISDLGLA 336 >5USZ-A nrPDB Length = 289 Score = 29.6 bits (65), Expect = 2.1, Method: Compositional matrix adjust. Identities = 15/64 (23%), Positives = 34/64 (53%), Gaps = 6/64 (9%) Query: 155 LQLSLRILDILEYIHEHEYVHGDIKASNLLL------NYKNPDQVYLVDYGLAYRYCPEG 208 L+++ ++ + ++ E+ +HG++ A N+LL NP + L D G++ P+ Sbjct: 116 LEVAKQLAAAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKD 175 Query: 209 VHKE 212 + +E Sbjct: 176 ILQE 179 >2PSQ-A nrPDB Length = 370 Score = 29.6 bits (65), Expect = 2.2, Method: Compositional matrix adjust. Identities = 38/177 (21%), Positives = 80/177 (45%), Gaps = 25/177 (14%) Query: 39 VGLPIGQGGFGCIYLADMNSSESVGSD-------APCVVKVEPSDN-----GPLFTELKF 86 +G P+G+G FG + +A E+VG D VK+ D L +E++ Sbjct: 85 LGKPLGEGCFGQVVMA-----EAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEM 139 Query: 87 YQRAAKPEQIQKWIR--TRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEA 144 + K + I + T+ + +Y G + ++ R M+ + D+ ++ E Sbjct: 140 MKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGME-YSYDINRVPE- 197 Query: 145 NAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 ++ + K ++ + ++ +EY+ + +H D+ A N+L+ N + + D+GLA Sbjct: 198 --EQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENN--VMKIADFGLA 250 >6B2Q-A nrPDB Length = 317 Score = 29.6 bits (65), Expect = 2.2, Method: Compositional matrix adjust. Identities = 28/118 (23%), Positives = 52/118 (44%), Gaps = 9/118 (7%) Query: 90 AAKPEQIQKWI----RTRKLKYLGVPKYWGSGLHDKNGKS-YRFMIMDRF-GSDLQKIYE 143 ++ PE I+++ T L + G+ G NG+ +++M+ G L + + Sbjct: 70 SSDPEFIERFRAEARTTAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLK 129 Query: 144 ANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 R S + L + + L+ H VH D+K N+L+ QV + D+G+A Sbjct: 130 -RTGRLSLRHALDMLEQTGRALQIAHAAGLVHRDVKPGNILITPTG--QVKITDFGIA 184 >6J5U-C nrPDB Length = 426 Score = 29.6 bits (65), Expect = 2.5, Method: Compositional matrix adjust. Identities = 41/175 (23%), Positives = 72/175 (41%), Gaps = 41/175 (23%) Query: 43 IGQGGFGCIYLA--DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQ--- 97 +G+GGFGC++ D S + + VV V + KPE Q Sbjct: 92 LGEGGFGCVFKGWIDQTSLTASRPGSGIVVAV----------------KQLKPEGFQGHK 135 Query: 98 KWIRTRKLKYLG---------VPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKR 148 +W+ ++ YLG + Y G + Y FM GS ++ A+ Sbjct: 136 EWL--TEVNYLGQLSHPNLVLLVGYCAEG--ENRLLVYEFMPK---GSLENHLFRRGAQP 188 Query: 149 FSRKTVLQLSLRILDILEYIHE--HEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 + +++++ L ++HE + ++ D KA+N+LL+ L D+GLA Sbjct: 189 LTWAIRMKVAVGAAKGLTFLHEAKSQVIYRDFKAANILLDAD--FNAKLSDFGLA 241 >3TT0-A nrPDB Length = 382 Score = 29.6 bits (65), Expect = 2.5, Method: Compositional matrix adjust. Identities = 40/180 (22%), Positives = 77/180 (42%), Gaps = 31/180 (17%) Query: 39 VGLPIGQGGFGCIYLADMNSSESVGSD-------APCVVKVEPSDN-----GPLFTELKF 86 +G P+G+G FG + LA E++G D VK+ SD L +E++ Sbjct: 73 LGKPLGEGAFGQVVLA-----EAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEM 127 Query: 87 YQRAAKPEQIQKWIR--TRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEA 144 + K + I + T+ + +Y G + R + R L+ Y Sbjct: 128 MKMIGKHKNIINLLGACTQDGPLYVIVEYASKG-------NLREYLQARRPPGLEYSYNP 180 Query: 145 N---AKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 + ++ S K ++ + ++ +EY+ + +H D+ A N+L+ N + + D+GLA Sbjct: 181 SHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDN--VMKIADFGLA 238 >2Y6O-A nrPDB Length = 291 Score = 29.6 bits (65), Expect = 2.7, Method: Compositional matrix adjust. Identities = 18/54 (33%), Positives = 31/54 (57%), Gaps = 5/54 (9%) Query: 151 RKTVLQLSLRILDI---LEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 R TV+QL + I ++Y+ + YVH D+ A N+L+N +V D+G++ Sbjct: 112 RFTVIQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVS--DFGMS 163 >5E8V-A nrPDB Length = 316 Score = 29.3 bits (64), Expect = 3.0, Method: Compositional matrix adjust. Identities = 15/33 (45%), Positives = 21/33 (63%), Gaps = 2/33 (6%) Query: 174 VHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCP 206 VH D+K+SN+L+ KN L D+GL+ R P Sbjct: 143 VHRDLKSSNILV--KNDLTCCLCDFGLSLRLDP 173 >5TQX-A nrPDB Length = 655 Score = 29.3 bits (64), Expect = 3.0, Method: Compositional matrix adjust. Identities = 34/168 (20%), Positives = 68/168 (40%), Gaps = 16/168 (9%) Query: 37 WKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQI 96 W++ +G GGFG + L + + C +++ + E++ + Sbjct: 10 WEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCHEIQI---------M 60 Query: 97 QKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYE--ANAKRFSRKTV 154 +K +K VP+ +HD + + G DL+K+ N + Sbjct: 61 KKLNHANVVKACDVPEELNILIHDVPLLAMEYC----SGGDLRKLLNKPENCCGLKESQI 116 Query: 155 LQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVY-LVDYGLA 201 L L I + Y+HE++ +H D+K N++L ++ ++D G A Sbjct: 117 LSLLSDIGSGIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYA 164 >3RP9-A nrPDB Length = 458 Score = 29.3 bits (64), Expect = 3.0, Method: Compositional matrix adjust. Identities = 18/74 (24%), Positives = 38/74 (51%), Gaps = 3/74 (4%) Query: 128 FMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY 187 +++++ SD +K++ + + L +L ++Y+H +H D+K +N L+N Sbjct: 133 YVVLEIADSDFKKLFRTPVY-LTELHIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQ 191 Query: 188 KNPDQVYLVDYGLA 201 V + D+GLA Sbjct: 192 DC--SVKVCDFGLA 203 >3UDB-A nrPDB Length = 317 Score = 29.3 bits (64), Expect = 3.0, Method: Compositional matrix adjust. Identities = 15/55 (27%), Positives = 26/55 (47%) Query: 145 NAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYG 199 NA RFS +++ + Y H + H D+K N LL+ ++ + D+G Sbjct: 108 NAGRFSEDEARFFFQQLISGVSYAHAMQVAHRDLKLENTLLDGSPAPRLKIADFG 162 >4O2Z-A nrPDB Length = 377 Score = 29.3 bits (64), Expect = 3.1, Method: Compositional matrix adjust. Identities = 14/42 (33%), Positives = 26/42 (61%), Gaps = 2/42 (4%) Query: 160 RILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 +IL L+Y+H H D+K +NL+ N ++ ++D+GL+ Sbjct: 158 QILRGLKYLHSANVAHRDLKPANLVTNISC--ELKIIDFGLS 197 >6GU6-A nrPDB Length = 302 Score = 29.3 bits (64), Expect = 3.5, Method: Compositional matrix adjust. Identities = 20/76 (26%), Positives = 36/76 (47%), Gaps = 4/76 (5%) Query: 128 FMIMDRFGSDLQKIYEA--NAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLL 185 ++I + DL+K ++ + V +IL + + H +H D+K NLL+ Sbjct: 82 YLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLI 141 Query: 186 NYKNPDQVYLVDYGLA 201 + K + L D+GLA Sbjct: 142 DDKG--TIKLADFGLA 155 >6O6Q-A nrPDB Length = 335 Score = 29.3 bits (64), Expect = 3.5, Method: Compositional matrix adjust. Identities = 15/46 (32%), Positives = 28/46 (60%), Gaps = 1/46 (2%) Query: 161 ILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCP 206 +L L+Y H +H D+K N+++++ + + L+D+GLA Y P Sbjct: 144 LLKALDYSHSMGIMHRDVKPHNVMIDH-DKKLLRLIDWGLAEYYHP 188 >4YHJ-A nrPDB Length = 584 Score = 28.9 bits (63), Expect = 3.6, Method: Compositional matrix adjust. Identities = 31/128 (24%), Positives = 53/128 (41%), Gaps = 11/128 (8%) Query: 135 GSDLQ-KIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQV 193 G DL+ IY F + + + + LE + V+ D+K N+LL+ + + Sbjct: 269 GGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRG--HI 326 Query: 194 YLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQ 253 + D GLA PEG R GT+ + + + N + D LG + + Sbjct: 327 RISDLGLATEI-PEGQR-------VRGRVGTVGYMAPEVVNNEKYTFSPDWWGLGCLIYE 378 Query: 254 WLTGHLPW 261 + GH P+ Sbjct: 379 MIQGHSPF 386 >3PNU-A nrPDB Length = 359 Score = 28.9 bits (63), Expect = 3.8, Method: Compositional matrix adjust. Identities = 16/57 (28%), Positives = 30/57 (52%), Gaps = 1/57 (1%) Query: 129 MIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLL 185 +MDR S+ KIYE AK F R ++ + + E + ++E ++ I +L++ Sbjct: 161 FVMDR-ESNFAKIYEKLAKHFPRLKIVMEHITTKTLCELLKDYENLYATITLHHLII 216 >3SOA-A nrPDB Length = 444 Score = 28.9 bits (63), Expect = 4.1, Method: Compositional matrix adjust. Identities = 17/43 (39%), Positives = 25/43 (58%), Gaps = 1/43 (2%) Query: 160 RILDILEYIHEHEYVHGDIKASNLLLNYK-NPDQVYLVDYGLA 201 +IL+ + + H+ VH ++K NLLL K V L D+GLA Sbjct: 118 QILEAVLHCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLA 160 >4AGU-A nrPDB Length = 311 Score = 28.9 bits (63), Expect = 4.3, Method: Compositional matrix adjust. Identities = 13/48 (27%), Positives = 26/48 (54%), Gaps = 2/48 (4%) Query: 154 VLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 V ++ + L + + H+H +H D+K N+L+ + + L D+G A Sbjct: 104 VKSITWQTLQAVNFCHKHNCIHRDVKPENILITKHS--VIKLCDFGFA 149 >2PMN-X nrPDB Length = 348 Score = 28.9 bits (63), Expect = 4.4, Method: Compositional matrix adjust. Identities = 32/109 (29%), Positives = 50/109 (45%), Gaps = 24/109 (22%) Query: 161 ILDILEYIH-EHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPK- 218 +L+ YIH E H D+K SN+L++ KN +V L D+G EY D K Sbjct: 160 VLNSFSYIHNEKNICHRDVKPSNILMD-KNG-RVKLSDFG----------ESEYMVDKKI 207 Query: 219 RCHDGTIE------FTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPW 261 + GT E F++ ++NG + D+ LG C+ +P+ Sbjct: 208 KGSRGTYEFMPPEFFSNESSYNGA----KVDIWSLGICLYVMFYNVVPF 252 >1FVR-A nrPDB Length = 327 Score = 28.9 bits (63), Expect = 4.5, Method: Compositional matrix adjust. Identities = 13/61 (21%), Positives = 32/61 (52%), Gaps = 2/61 (3%) Query: 141 IYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGL 200 I + A S + +L + + ++Y+ + +++H D+ A N+L+ ++ D+GL Sbjct: 131 IANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKI--ADFGL 188 Query: 201 A 201 + Sbjct: 189 S 189 >1C0L-A nrPDB Length = 363 Score = 28.5 bits (62), Expect = 4.7, Method: Compositional matrix adjust. Identities = 18/42 (42%), Positives = 22/42 (52%), Gaps = 5/42 (11%) Query: 206 PEGVHKEYKE----DPKRCHDGTIEFTSIDAHN-GVAPSRRG 242 PE V + K DP DGTIE + HN G+ P+RRG Sbjct: 251 PETVQRILKHCLRLDPTISSDGTIEGIEVLRHNVGLRPARRG 292 >6GQK-A nrPDB Length = 328 Score = 28.5 bits (62), Expect = 4.7, Method: Compositional matrix adjust. Identities = 41/173 (23%), Positives = 71/173 (41%), Gaps = 21/173 (12%) Query: 40 GLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVE---PSDNG----PLFTELKFYQRAAK 92 G +G G FG + + + + SDA V V+ PS + L +ELK Sbjct: 46 GKTLGAGAFGKV--VEATAQGLIKSDAAMTVAVKMLKPSAHSTEREALMSELKVLSYLGN 103 Query: 93 PEQIQKWIR--TRKLKYLGVPKY--WGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKR 148 E I + T L + +Y +G L+ K F+ DL K + Sbjct: 104 HENIVNLLGACTHGGPTLVITEYCCYGDLLNFLRRKRDEFVPYKVAPEDLYKDF------ 157 Query: 149 FSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 + + +L S ++ + ++ +H D+ A N+LL + N ++ D+GLA Sbjct: 158 LTLEHLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGNITKI--CDFGLA 208 >5JZN-A nrPDB Length = 280 Score = 28.5 bits (62), Expect = 4.7, Method: Compositional matrix adjust. Identities = 22/79 (27%), Positives = 38/79 (48%), Gaps = 6/79 (7%) Query: 126 YRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLL 185 Y M + + G I N +++ + + + ++Y+H VH DIK NLL+ Sbjct: 93 YLVMELVKGGDLFDAITSTN--KYTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLV 150 Query: 186 NYKNPD---QVYLVDYGLA 201 Y++ D + L D+GLA Sbjct: 151 -YEHQDGSKSLKLGDFGLA 168 >3SXS-A nrPDB Length = 268 Score = 28.5 bits (62), Expect = 5.0, Method: Compositional matrix adjust. Identities = 29/146 (19%), Positives = 60/146 (41%), Gaps = 25/146 (17%) Query: 43 IGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRT 102 +G G FG + L V V+ G + +E +F+Q A + + K Sbjct: 16 LGSGQFGVVKLGKWKGQYDVA--------VKMIKEGSM-SEDEFFQEA---QTMMKLSHP 63 Query: 103 RKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSD--LQKIYEANAKRFSRKTVLQLSLR 160 + +K+ GV K Y I+ + S+ L ++ K +L++ Sbjct: 64 KLVKFYGV-----------CSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYD 112 Query: 161 ILDILEYIHEHEYVHGDIKASNLLLN 186 + + + ++ H+++H D+ A N L++ Sbjct: 113 VCEGMAFLESHQFIHRDLAARNCLVD 138 >4FL3-A nrPDB Length = 635 Score = 28.5 bits (62), Expect = 5.2, Method: Compositional matrix adjust. Identities = 14/50 (28%), Positives = 31/50 (62%), Gaps = 2/50 (4%) Query: 152 KTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 K +++L ++ ++Y+ E +VH D+ A N+LL ++ ++ D+GL+ Sbjct: 469 KNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKI--SDFGLS 516 >4C59-A nrPDB Length = 340 Score = 28.5 bits (62), Expect = 5.3, Method: Compositional matrix adjust. Identities = 17/55 (30%), Positives = 30/55 (54%), Gaps = 4/55 (7%) Query: 149 FSRKTVLQLSLRILDILEYIHEHE--YVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 S TVL++ + ++++H + +H D+K NLLL+ N + L D+G A Sbjct: 132 LSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLS--NQGTIKLCDFGSA 184 >4WNO-A nrPDB Length = 287 Score = 28.5 bits (62), Expect = 5.6, Method: Compositional matrix adjust. Identities = 32/135 (23%), Positives = 55/135 (40%), Gaps = 16/135 (11%) Query: 135 GSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY-----KN 189 G DL A + S T+ +I + +H +H D+K N+LL+ N Sbjct: 101 GGDLADYLHA-MRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRAN 159 Query: 190 PD--QVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEIL 247 P+ +V + D+G A RY + C G+ + + + + DL + Sbjct: 160 PNSIRVKIADFGFA-RYLQSNMMAA-----TLC--GSPMYMAPEVIMSQHYDGKADLWSI 211 Query: 248 GYCMIQWLTGHLPWE 262 G + Q LTG P++ Sbjct: 212 GTIVYQCLTGKAPFQ 226 >3LXX-A nrPDB Length = 239 Score = 28.5 bits (62), Expect = 5.9, Method: Compositional matrix adjust. Identities = 28/81 (34%), Positives = 37/81 (45%), Gaps = 10/81 (12%) Query: 313 EKPLYENLRDILLQGLKAIGSKDDGKLDLSV-VENGGLKAKTITKKRKKEIEESKE---- 367 ++P LR I+L G G G L V + G AK+ITKK +K KE Sbjct: 23 QEPRNSQLR-IVLVGKTGAGKSATGNSILGRKVFHSGTAAKSITKKCEKRSSSWKETELV 81 Query: 368 ----PGVEDTEWSNTQTEEAI 384 PG+ DTE N +T + I Sbjct: 82 VVDTPGIFDTEVPNAETSKEI 102 >1U59-A nrPDB Length = 287 Score = 28.5 bits (62), Expect = 6.0, Method: Compositional matrix adjust. Identities = 18/67 (26%), Positives = 31/67 (46%), Gaps = 2/67 (2%) Query: 135 GSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVY 194 G L K + V +L ++ ++Y+ E +VH D+ A N+LL N Sbjct: 93 GGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLL--VNRHYAK 150 Query: 195 LVDYGLA 201 + D+GL+ Sbjct: 151 ISDFGLS 157 >3PPZ-A nrPDB Length = 309 Score = 28.1 bits (61), Expect = 6.4, Method: Compositional matrix adjust. Identities = 55/286 (19%), Positives = 117/286 (40%), Gaps = 56/286 (19%) Query: 43 IGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIR- 101 IG G FG ++ A+ + GSD VK+ E F+ E++ +++R Sbjct: 45 IGAGSFGTVHRAEWH-----GSDV--AVKI--------LMEQDFHA-----ERVNEFLRE 84 Query: 102 ---TRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF---GSDLQKIYEANAK-RFSRKTV 154 ++L++ + + G+ N I+ + GS + ++++ A+ + + Sbjct: 85 VAIMKRLRHPNIVLFMGAVTQPPN-----LSIVTEYLSRGSLYRLLHKSGAREQLDERRR 139 Query: 155 LQLSLRILDILEYIHEHE--YVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKE 212 L ++ + + Y+H VH D+K+ NLL++ K V + D+GL+ K Sbjct: 140 LSMAYDVAKGMNYLHNRNPPIVHRDLKSPNLLVDKKY--TVKVCDFGLSRL-------KA 190 Query: 213 YKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVR 272 + GT E+ + + + + D+ G + + T PW NL + V Sbjct: 191 STFLSSKSAAGTPEWMAPEVLRDEPSNEKSDVYSFGVILWELATLQQPW-GNLNPAQVVA 249 Query: 273 DSKIRYRE---------NIASLMDKCFPEKNKPGEIAKYMETVKLL 309 + + +A++++ C+ N+P + + + LL Sbjct: 250 AVGFKCKRLEIPRNLNPQVAAIIEGCW--TNEPWKRPSFATIMDLL 293 >4IPV-A nrPDB Length = 137 Score = 28.1 bits (61), Expect = 6.8, Method: Compositional matrix adjust. Identities = 21/82 (25%), Positives = 35/82 (42%), Gaps = 10/82 (12%) Query: 290 FPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDILLQGLK--------AIGSKDDGKLDL 341 F E+N+ A+ + +L Y R I +Q LK +IG G + Sbjct: 5 FTERNELQSAAEELNA--MLQYARSEAVSQRRAISIQALKDKDWGKGLSIGVLASGSIAA 62 Query: 342 SVVENGGLKAKTITKKRKKEIE 363 + ++ G +A T+T K K +E Sbjct: 63 PLRKHDGFRAATLTAKEKSAVE 84 >4WWA-A nrPDB Length = 261 Score = 28.1 bits (61), Expect = 7.3, Method: Compositional matrix adjust. Identities = 12/35 (34%), Positives = 22/35 (62%), Gaps = 1/35 (2%) Query: 168 IHEHEYVHGDIKASNLLLNYKNPDQV-YLVDYGLA 201 +H ++Y HGD+ +SN++L +L+D+GL Sbjct: 152 LHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLG 186 >5CLR-A nrPDB Length = 451 Score = 28.1 bits (61), Expect = 7.7, Method: Compositional matrix adjust. Identities = 24/101 (23%), Positives = 46/101 (45%), Gaps = 15/101 (14%) Query: 154 VLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEY 213 VL + + + ++ HE +H D+K N++L+ Q +LVD+G Sbjct: 178 VLGIMISVCHQVKQFHELGLIHRDLKPGNIMLDADM--QCHLVDFG----------SSSS 225 Query: 214 KEDPKRCHDGTIEFTSIDAH---NGVAPSRRGDLEILGYCM 251 ++PK GT + + + + + +A S+ DL L Y + Sbjct: 226 DKEPKPASWGTASYLAPELNAQEDFIAFSQVSDLFALAYSL 266 >3LLT-A nrPDB Length = 360 Score = 28.1 bits (61), Expect = 7.8, Method: Compositional matrix adjust. Identities = 28/105 (26%), Positives = 47/105 (44%), Gaps = 6/105 (5%) Query: 84 LKFYQRAAKPE-QIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIY 142 +K Y R+AK E I K I+ + + KY G ++ + +I + G L +I Sbjct: 71 IKKYTRSAKIEADILKKIQNDDINNNNIVKYHGKFMY----YDHMCLIFEPLGPSLYEII 126 Query: 143 EANAKR-FSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLN 186 N F + + + IL L Y+ + H D+K N+LL+ Sbjct: 127 TRNNYNGFHIEDIKLYCIEILKALNYLRKMSLTHTDLKPENILLD 171 >1ZXE-A nrPDB Length = 303 Score = 27.7 bits (60), Expect = 8.1, Method: Compositional matrix adjust. Identities = 14/42 (33%), Positives = 24/42 (57%), Gaps = 2/42 (4%) Query: 160 RILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 +IL+ L YIH +H ++K N+ ++ V + D+GLA Sbjct: 124 QILEALSYIHSQGIIHRNLKPMNIFID--ESRNVKIGDFGLA 163 >6CTH-A nrPDB Length = 309 Score = 27.7 bits (60), Expect = 8.2, Method: Compositional matrix adjust. Identities = 17/40 (42%), Positives = 24/40 (60%), Gaps = 5/40 (12%) Query: 165 LEYIHE---HEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 L Y+HE H +H DIK SN++L+ + L D+GLA Sbjct: 126 LLYLHEEGDHCVLHRDIKTSNIMLD--SSFNAKLGDFGLA 163 >6CKI-A nrPDB Length = 316 Score = 27.7 bits (60), Expect = 8.3, Method: Compositional matrix adjust. Identities = 15/51 (29%), Positives = 27/51 (52%), Gaps = 4/51 (7%) Query: 155 LQLSLRILDI---LEYIHEHEYVHGDIKASNLLLNYKNP-DQVYLVDYGLA 201 L+ S+ + D+ L+++H H D+K N+L + N V + D+GL Sbjct: 111 LEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFGLG 161 >5C26-A nrPDB Length = 299 Score = 27.7 bits (60), Expect = 8.3, Method: Compositional matrix adjust. Identities = 14/50 (28%), Positives = 31/50 (62%), Gaps = 2/50 (4%) Query: 152 KTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 K +++L ++ ++Y+ E +VH D+ A N+LL ++ ++ D+GL+ Sbjct: 127 KNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKI--SDFGLS 174 >5VC6-A nrPDB Length = 289 Score = 27.7 bits (60), Expect = 8.6, Method: Compositional matrix adjust. Identities = 14/38 (36%), Positives = 20/38 (52%) Query: 149 FSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLN 186 F + L L++ L YIH VH DIK SN+ ++ Sbjct: 112 FKEAELKDLLLQVGRGLRYIHSMSLVHMDIKPSNIFIS 149 >1TLV-A nrPDB Length = 221 Score = 27.7 bits (60), Expect = 9.5, Method: Compositional matrix adjust. Identities = 14/58 (24%), Positives = 29/58 (50%), Gaps = 4/58 (6%) Query: 15 AKRHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKV 72 KR ++FA+G+ M K + V LP + GF +++ + +E + P ++ + Sbjct: 69 TKRLYKDEFAIGKEALVMVKNKTGVSLPEDEAGFIALHIVNAELNE----EMPNIINI 122 >3QA8-A nrPDB Length = 676 Score = 27.7 bits (60), Expect = 9.9, Method: Compositional matrix adjust. Identities = 14/43 (32%), Positives = 24/43 (55%), Gaps = 3/43 (6%) Query: 161 ILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVY--LVDYGLA 201 I L Y+HE+ +H D+K N++L P ++ ++D G A Sbjct: 130 ISSALRYLHENRIIHRDLKPENIVLQ-PGPQRLIHKIIDLGYA 171 >3RAW-A nrPDB Length = 381 Score = 27.7 bits (60), Expect = 10.0, Method: Compositional matrix adjust. Identities = 11/43 (25%), Positives = 23/43 (53%) Query: 143 EANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLL 185 E N + + V ++ ++ L ++HE++ H D+K N+L Sbjct: 146 ENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILF 188 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 2RSV-A nrPDB 532 e-152 2LAV-A nrPDB 460 e-130 4TN6-A nrPDB 336 1e-92 5UU1-A nrPDB 318 3e-87 4NT4-A nrPDB 314 5e-86 3SV0-A nrPDB 313 7e-86 2C47-A nrPDB 307 4e-84 2CHL-A nrPDB 307 4e-84 5FQD-C nrPDB 307 5e-84 2CMW-A nrPDB 306 1e-83 1CSN-A nrPDB 292 2e-79 2JII-A nrPDB 283 1e-76 5X18-A nrPDB 277 7e-75 4XHH-A nrPDB 270 6e-73 4XHL-A nrPDB 270 8e-73 4NFN-A nrPDB 230 7e-61 4BTK-A nrPDB 230 7e-61 3DB8-A nrPDB 218 3e-57 5JN2-A nrPDB 202 3e-52 3D2K-A nrPDB 193 1e-49 4UZD-A nrPDB 192 2e-49 4I6B-A nrPDB 189 2e-48 4JXF-A nrPDB 182 2e-46 3UTO-A nrPDB 181 6e-46 1KOA-A nrPDB 178 3e-45 2OU7-A nrPDB 176 1e-44 4J52-A nrPDB 176 1e-44 3ORP-A nrPDB 175 2e-44 4YZB-A nrPDB 175 4e-44 3MA6-A nrPDB 175 4e-44 1KOB-A nrPDB 171 3e-43 4B8L-A nrPDB 171 4e-43 3Q5I-A nrPDB 168 4e-42 5LOH-A nrPDB 168 4e-42 5XZW-A nrPDB 167 8e-42 3HZT-A nrPDB 166 2e-41 1VZO-A nrPDB 164 6e-41 4PDS-A nrPDB 163 1e-40 3DXN-A nrPDB 163 1e-40 3LIJ-A nrPDB 161 7e-40 3IS5-A nrPDB 158 3e-39 2HK5-A nrPDB 157 6e-39 3COM-A nrPDB 157 9e-39 1U5R-A nrPDB 157 1e-38 3NCG-A nrPDB 155 3e-38 2X4F-A nrPDB 155 3e-38 3DFA-A nrPDB 155 3e-38 4C0T-A nrPDB 155 5e-38 2WTK-C nrPDB 154 6e-38 2GCD-A nrPDB 154 8e-38 4QTB-A nrPDB 152 3e-37 3ORZ-A nrPDB 151 4e-37 5NGU-A nrPDB 150 7e-37 4YNZ-A nrPDB 149 2e-36 4Y83-A nrPDB 148 3e-36 4NST-A nrPDB 147 7e-36 4QMW-A nrPDB 147 8e-36 1V0B-A nrPDB 147 1e-35 5EFQ-A nrPDB 146 1e-35 4IDT-A nrPDB 146 2e-35 4G3E-A nrPDB 146 2e-35 5J5T-A nrPDB 142 3e-34 4JG6-A nrPDB 141 5e-34 5VO2-A nrPDB 137 7e-33 3FXW-A nrPDB 134 5e-32 5B2L-A nrPDB 134 5e-32 5L2Q-C nrPDB 129 2e-30 4IC8-A nrPDB 128 3e-30 1UA2-A nrPDB 127 8e-30 4MYG-A nrPDB 124 8e-29 5UV4-A nrPDB 111 4e-25 5J0A-A nrPDB 111 6e-25 Sequences not found previously or not previously below threshold: 4B6L-A nrPDB 170 1e-42 4MVF-A nrPDB 163 1e-40 4AF3-A nrPDB 163 1e-40 2BDW-A nrPDB 161 4e-40 4RGJ-A nrPDB 160 7e-40 5ES1-A nrPDB 160 1e-39 3KK8-A nrPDB 159 3e-39 6C9D-A nrPDB 158 3e-39 2HAK-A nrPDB 158 4e-39 2QNJ-A nrPDB 158 6e-39 3H4J-B nrPDB 157 8e-39 3MN3-A nrPDB 157 8e-39 5FG8-A nrPDB 156 2e-38 2V7O-A nrPDB 155 2e-38 5IG1-A nrPDB 155 3e-38 1FOT-A nrPDB 155 5e-38 2WQN-A nrPDB 154 5e-38 2VN9-A nrPDB 154 6e-38 5D9K-A nrPDB 154 8e-38 5KZ7-A nrPDB 153 1e-37 4CZT-A nrPDB 153 2e-37 4LG4-A nrPDB 152 2e-37 4RLP-A nrPDB 152 2e-37 3BHH-A nrPDB 152 3e-37 2Z7Q-A nrPDB 152 3e-37 5X3F-B nrPDB 151 3e-37 6AO5-A nrPDB 151 4e-37 4L42-A nrPDB 151 4e-37 4D2V-A nrPDB 151 6e-37 2J90-A nrPDB 151 6e-37 4CQG-A nrPDB 150 1e-36 5JZN-A nrPDB 150 1e-36 6FDY-U nrPDB 150 1e-36 4RED-A nrPDB 150 2e-36 5WAX-A nrPDB 149 2e-36 2VZ6-A nrPDB 149 2e-36 4REW-A nrPDB 149 2e-36 5U6Y-A nrPDB 148 3e-36 5N23-A nrPDB 148 3e-36 4WNO-A nrPDB 148 3e-36 6CCF-A nrPDB 148 3e-36 1AD5-A nrPDB 147 7e-36 3SOA-A nrPDB 147 8e-36 4CFH-A nrPDB 146 1e-35 4CFF-A nrPDB 146 2e-35 3HDN-A nrPDB 145 2e-35 4CSV-A nrPDB 145 3e-35 5EZV-A nrPDB 145 5e-35 2JDO-A nrPDB 145 5e-35 3UC3-A nrPDB 145 5e-35 3KN6-A nrPDB 144 5e-35 2XIK-A nrPDB 144 6e-35 2YZA-A nrPDB 144 6e-35 4WB7-A nrPDB 144 8e-35 6CMJ-A nrPDB 143 1e-34 4D28-A nrPDB 143 1e-34 4RA4-A nrPDB 143 1e-34 4EQM-A nrPDB 143 1e-34 2JC6-A nrPDB 143 1e-34 3UDB-A nrPDB 143 2e-34 5YKS-A nrPDB 143 2e-34 3ZUT-A nrPDB 142 2e-34 4APC-A nrPDB 142 3e-34 3Q53-A nrPDB 142 3e-34 6FD3-A nrPDB 142 3e-34 2BRG-A nrPDB 142 3e-34 6BDL-A nrPDB 141 3e-34 3PFQ-A nrPDB 141 4e-34 6QAU-A nrPDB 141 4e-34 2I0E-A nrPDB 141 5e-34 2YAB-A nrPDB 141 5e-34 5F9E-A nrPDB 141 5e-34 3NIZ-A nrPDB 141 5e-34 6E9W-A nrPDB 140 9e-34 2PL0-A nrPDB 140 9e-34 5KCV-A nrPDB 140 1e-33 4FG9-A nrPDB 139 1e-33 3TXO-A nrPDB 139 1e-33 5YV8-A nrPDB 139 1e-33 2A27-A nrPDB 139 1e-33 3MV5-A nrPDB 139 2e-33 1ZWS-A nrPDB 139 2e-33 6ED6-A nrPDB 139 2e-33 3A8W-A nrPDB 139 2e-33 2JAM-A nrPDB 138 3e-33 4FZF-B nrPDB 138 4e-33 3F3Z-A nrPDB 138 4e-33 3PPZ-A nrPDB 138 4e-33 2YCR-A nrPDB 138 5e-33 2W4O-A nrPDB 137 7e-33 3I6U-A nrPDB 137 9e-33 4AW2-A nrPDB 137 9e-33 4UY9-A nrPDB 137 9e-33 6BXI-A nrPDB 137 1e-32 3TKU-A nrPDB 136 1e-32 3HKO-A nrPDB 136 1e-32 5HI2-A nrPDB 136 1e-32 4FR4-A nrPDB 136 1e-32 6E2O-A nrPDB 136 1e-32 3GUB-A nrPDB 136 2e-32 4NIF-A nrPDB 136 2e-32 2H8H-A nrPDB 136 2e-32 3TAC-A nrPDB 135 3e-32 6F3F-A nrPDB 135 3e-32 2BPM-A nrPDB 135 3e-32 3A4O-X nrPDB 134 6e-32 4EBW-A nrPDB 134 7e-32 2HW6-A nrPDB 134 7e-32 3CJF-A nrPDB 134 8e-32 2DQ7-X nrPDB 134 8e-32 3KA0-A nrPDB 133 9e-32 3DTC-A nrPDB 133 1e-31 1NY3-A nrPDB 133 2e-31 5SYS-A nrPDB 133 2e-31 2OZA-A nrPDB 132 2e-31 6CQF-A nrPDB 132 2e-31 2J0K-A nrPDB 132 2e-31 5DYK-A nrPDB 132 3e-31 6HXF-B nrPDB 132 3e-31 4AU8-A nrPDB 132 3e-31 3VN9-A nrPDB 131 4e-31 2Y7J-A nrPDB 131 6e-31 5D7A-A nrPDB 131 7e-31 2VD5-A nrPDB 131 7e-31 5HIE-A nrPDB 131 7e-31 2UV2-A nrPDB 131 7e-31 2I6L-A nrPDB 130 8e-31 1TKI-A nrPDB 130 9e-31 3NYO-A nrPDB 130 1e-30 3DAK-A nrPDB 130 1e-30 3OMV-A nrPDB 130 1e-30 2F57-A nrPDB 129 1e-30 4HZS-A nrPDB 129 2e-30 5ZTN-A nrPDB 129 2e-30 2XNP-A nrPDB 129 2e-30 5G6V-A nrPDB 129 3e-30 4KRC-A nrPDB 129 3e-30 4KIK-B nrPDB 128 3e-30 1PHK-A nrPDB 128 3e-30 4ZSG-A nrPDB 128 4e-30 1U54-B nrPDB 128 6e-30 3OZ6-A nrPDB 128 6e-30 6B2Q-A nrPDB 128 6e-30 4X3F-A nrPDB 128 6e-30 4OW8-A nrPDB 128 6e-30 5FET-A nrPDB 127 7e-30 4U41-A nrPDB 127 7e-30 6GU6-A nrPDB 127 7e-30 3E7O-A nrPDB 127 9e-30 5UUU-A nrPDB 127 1e-29 4BGQ-A nrPDB 127 1e-29 4XEY-B nrPDB 127 1e-29 4AN9-A nrPDB 127 1e-29 5AWM-A nrPDB 126 1e-29 5DBX-A nrPDB 126 1e-29 4E93-A nrPDB 126 1e-29 6NPU-A nrPDB 126 1e-29 5TQX-A nrPDB 126 2e-29 4UYA-A nrPDB 126 2e-29 3PVW-A nrPDB 126 2e-29 5Z33-A nrPDB 126 2e-29 2FO0-A nrPDB 126 2e-29 1G3N-A nrPDB 125 3e-29 3QA8-A nrPDB 125 3e-29 4AGU-A nrPDB 125 4e-29 5KKR-C nrPDB 125 4e-29 3EQC-A nrPDB 125 4e-29 5H2U-A nrPDB 125 4e-29 2XYN-A nrPDB 124 6e-29 1S9I-A nrPDB 124 6e-29 3C51-A nrPDB 124 6e-29 6DTL-A nrPDB 124 7e-29 3FME-A nrPDB 124 8e-29 4JDH-A nrPDB 124 8e-29 3MIA-A nrPDB 124 8e-29 3LM0-A nrPDB 124 8e-29 6CKI-A nrPDB 124 9e-29 4TNB-A nrPDB 124 9e-29 3ZDU-A nrPDB 124 9e-29 5Y86-A nrPDB 123 9e-29 4M7I-A nrPDB 123 1e-28 4KS7-A nrPDB 123 1e-28 6DBN-A nrPDB 123 1e-28 5TUR-A nrPDB 123 1e-28 3BGP-A nrPDB 123 1e-28 4EWQ-A nrPDB 123 1e-28 4FIE-A nrPDB 123 1e-28 4XBR-A nrPDB 123 1e-28 2Q0N-A nrPDB 123 1e-28 3OHT-A nrPDB 123 2e-28 2W96-B nrPDB 123 2e-28 4QNY-A nrPDB 123 2e-28 1U59-A nrPDB 123 2e-28 1JNK-A nrPDB 123 2e-28 4PWN-A nrPDB 123 2e-28 5AIR-A nrPDB 122 3e-28 4H1J-A nrPDB 122 3e-28 3AOX-A nrPDB 122 3e-28 6GVJ-A nrPDB 122 4e-28 2XS0-A nrPDB 121 4e-28 5U6B-A nrPDB 121 4e-28 3GC0-A nrPDB 121 5e-28 3FI2-A nrPDB 121 5e-28 1CM8-A nrPDB 121 6e-28 4PDO-A nrPDB 121 6e-28 3HMP-A nrPDB 121 7e-28 4HVI-A nrPDB 121 8e-28 5AP3-A nrPDB 121 8e-28 4RC3-A nrPDB 120 8e-28 3TT0-A nrPDB 120 8e-28 2OZO-A nrPDB 120 8e-28 5O2B-A nrPDB 120 8e-28 4K33-A nrPDB 120 1e-27 4OLI-A nrPDB 120 1e-27 3PG1-A nrPDB 120 1e-27 3GQL-A nrPDB 120 1e-27 5U6C-A nrPDB 120 1e-27 3QGY-A nrPDB 120 1e-27 3ALO-A nrPDB 119 2e-27 1ZXE-A nrPDB 119 2e-27 4BBM-A nrPDB 119 2e-27 5O2C-A nrPDB 119 2e-27 2F9G-A nrPDB 119 2e-27 6DBM-A nrPDB 119 3e-27 5WNO-A nrPDB 119 3e-27 4YHJ-A nrPDB 119 3e-27 5A46-A nrPDB 119 3e-27 5UIU-A nrPDB 118 3e-27 6GQK-A nrPDB 118 4e-27 3EB0-A nrPDB 118 5e-27 2OGV-A nrPDB 118 5e-27 5O0Y-A nrPDB 118 5e-27 3VHK-A nrPDB 118 5e-27 3IO7-A nrPDB 118 6e-27 4XCU-A nrPDB 118 6e-27 3V5Q-A nrPDB 118 6e-27 3N9X-A nrPDB 118 7e-27 5HLW-A nrPDB 117 7e-27 4GS6-A nrPDB 117 7e-27 2W1I-A nrPDB 117 8e-27 3NIE-A nrPDB 117 9e-27 3DKO-A nrPDB 117 1e-26 3QUP-A nrPDB 117 1e-26 4R7H-A nrPDB 117 1e-26 3GC9-A nrPDB 117 1e-26 4AT3-A nrPDB 117 1e-26 2ZMD-A nrPDB 117 1e-26 4EUU-A nrPDB 116 1e-26 4EUT-A nrPDB 116 1e-26 2PSQ-A nrPDB 116 1e-26 5HVK-A nrPDB 116 1e-26 5EG3-A nrPDB 116 1e-26 4C59-A nrPDB 116 2e-26 4JLC-A nrPDB 116 2e-26 4NEU-A nrPDB 115 3e-26 3M42-A nrPDB 115 3e-26 6E4F-A nrPDB 115 3e-26 6O8B-A nrPDB 115 4e-26 3C1X-A nrPDB 114 5e-26 3PLS-A nrPDB 114 5e-26 5MJB-A nrPDB 114 5e-26 2JD5-A nrPDB 114 5e-26 4X7Q-B nrPDB 114 6e-26 6NT9-A nrPDB 114 6e-26 4P5Q-A nrPDB 114 7e-26 5LPZ-A nrPDB 114 7e-26 4FL3-A nrPDB 114 8e-26 5KMM-A nrPDB 114 9e-26 5GNK-A nrPDB 114 1e-25 5LPV-A nrPDB 113 1e-25 2Y6O-A nrPDB 113 1e-25 5FM2-A nrPDB 113 1e-25 4Y93-A nrPDB 113 1e-25 1FVR-A nrPDB 113 1e-25 3BEA-A nrPDB 113 2e-25 5C26-A nrPDB 113 2e-25 5TOS-A nrPDB 113 2e-25 2A1A-B nrPDB 113 2e-25 4E20-A nrPDB 113 2e-25 3KRL-A nrPDB 113 2e-25 5L6P-A nrPDB 112 2e-25 1BYG-A nrPDB 112 3e-25 4F0G-A nrPDB 112 3e-25 3PP0-A nrPDB 112 3e-25 4LRM-A nrPDB 112 3e-25 3UIU-A nrPDB 112 3e-25 3RP9-A nrPDB 112 3e-25 4XI2-A nrPDB 112 3e-25 2R2P-A nrPDB 112 4e-25 1K9A-A nrPDB 111 4e-25 3LZB-A nrPDB 111 4e-25 1JPA-A nrPDB 111 6e-25 3BBT-B nrPDB 111 7e-25 4E7W-A nrPDB 111 8e-25 5AMN-A nrPDB 110 9e-25 3SXS-A nrPDB 110 1e-24 4YFF-A nrPDB 110 1e-24 6J5U-C nrPDB 109 1e-24 4XUF-A nrPDB 109 1e-24 5X02-A nrPDB 109 1e-24 2BUJ-A nrPDB 109 2e-24 4XLV-A nrPDB 109 2e-24 5X5O-A nrPDB 109 2e-24 5XD6-A nrPDB 109 3e-24 3UIM-A nrPDB 108 3e-24 4TPT-A nrPDB 108 3e-24 3G0E-A nrPDB 108 4e-24 5GRN-A nrPDB 108 4e-24 4O2Z-A nrPDB 108 5e-24 3ZBF-A nrPDB 108 6e-24 3DLS-A nrPDB 108 6e-24 3E3P-A nrPDB 108 7e-24 3LMG-A nrPDB 108 7e-24 3HNG-A nrPDB 107 8e-24 3KUL-B nrPDB 107 9e-24 6CTH-A nrPDB 107 1e-23 2VWV-A nrPDB 107 1e-23 3I81-A nrPDB 107 1e-23 5TE0-A nrPDB 106 1e-23 5IKW-A nrPDB 106 2e-23 4OTD-A nrPDB 106 2e-23 5X8I-B nrPDB 106 2e-23 4F9B-A nrPDB 106 2e-23 5VD3-A nrPDB 106 2e-23 2WO6-A nrPDB 105 3e-23 3QD2-B nrPDB 105 3e-23 2RIO-A nrPDB 105 4e-23 2H34-A nrPDB 104 5e-23 4CRS-A nrPDB 104 6e-23 5WNL-A nrPDB 104 6e-23 6HV0-A nrPDB 104 6e-23 6FYV-A nrPDB 104 7e-23 1LUF-A nrPDB 104 7e-23 4PL5-B nrPDB 103 1e-22 2PMN-X nrPDB 103 1e-22 6FEX-A nrPDB 103 2e-22 4CRL-A nrPDB 101 5e-22 6BSD-A nrPDB 101 5e-22 2QKW-B nrPDB 101 6e-22 3RAW-A nrPDB 101 7e-22 2X7G-A nrPDB 100 9e-22 3LLT-A nrPDB 100 1e-21 6BFN-A nrPDB 99 2e-21 2Y4I-B nrPDB 100 2e-21 4IAN-A nrPDB 100 2e-21 2PZI-A nrPDB 100 2e-21 4Y12-A nrPDB 99 3e-21 4WUA-A nrPDB 98 5e-21 4LQP-A nrPDB 97 1e-20 6O6Q-A nrPDB 97 1e-20 5E8V-A nrPDB 97 1e-20 5UNP-A nrPDB 96 2e-20 3ZZW-A nrPDB 96 3e-20 6FER-A nrPDB 96 3e-20 5OAT-A nrPDB 93 3e-19 3G2F-A nrPDB 93 3e-19 3SOC-A nrPDB 92 5e-19 4M66-A nrPDB 92 5e-19 3MDY-A nrPDB 91 7e-19 6DC0-A nrPDB 91 9e-19 5CEK-A nrPDB 90 1e-18 4RT7-A nrPDB 90 1e-18 5M07-A nrPDB 90 2e-18 4LFI-A nrPDB 90 2e-18 4MD7-E nrPDB 89 4e-18 6HMD-A nrPDB 89 4e-18 3Q4U-A nrPDB 88 5e-18 5XVU-A nrPDB 87 1e-17 5X1R-A nrPDB 87 1e-17 6EII-A nrPDB 86 2e-17 2PVN-A nrPDB 86 2e-17 2QLU-A nrPDB 86 4e-17 1PY5-A nrPDB 85 4e-17 5AR8-A nrPDB 85 7e-17 6EQI-C nrPDB 84 1e-16 4BTF-A nrPDB 83 2e-16 4M69-B nrPDB 83 2e-16 3MY0-A nrPDB 83 3e-16 4L00-A nrPDB 82 4e-16 4JRN-A nrPDB 80 2e-15 4IX6-A nrPDB 78 7e-15 4MWI-A nrPDB 76 2e-14 4L68-A nrPDB 76 2e-14 2WTK-B nrPDB 76 2e-14 5CLR-A nrPDB 76 3e-14 5VDK-A nrPDB 75 7e-14 5DMZ-A nrPDB 74 1e-13 5VC6-A nrPDB 74 1e-13 5USZ-A nrPDB 73 2e-13 6J6I-B nrPDB 69 3e-12 3REP-A nrPDB 63 2e-10 6G4J-A nrPDB 63 3e-10 5C01-A nrPDB 59 2e-09 4WOV-A nrPDB 59 2e-09 4CI6-B nrPDB 59 3e-09 4I94-A nrPDB 51 1e-06 3ENH-A nrPDB 51 1e-06 6EWX-A nrPDB 50 1e-06 4OAU-C nrPDB 49 4e-06 3BYV-A nrPDB 49 4e-06 3DZO-A nrPDB 48 6e-06 5VE6-A nrPDB 47 1e-05 6BHC-A nrPDB 46 2e-05 2W1Z-A nrPDB 46 2e-05 4AZW-A nrPDB 45 5e-05 4O1O-A nrPDB 45 5e-05 4AZV-A nrPDB 43 2e-04 4WWA-A nrPDB 41 9e-04 6M7Z-A nrPDB 39 0.004 6EAS-A nrPDB 38 0.006 6FAI-l nrPDB 38 0.009 4CYJ-A nrPDB 38 0.010 6FDN-A nrPDB 37 0.014 6G18-v nrPDB 37 0.016 1TQM-A nrPDB 36 0.022 4BVU-A nrPDB 36 0.032 2DLC-X nrPDB 35 0.046 3I4T-A nrPDB 35 0.048 4Q93-A nrPDB 35 0.071 6EF6-A nrPDB 34 0.098 2H2W-A nrPDB 33 0.30 4GYG-A nrPDB 33 0.34 5YK0-A nrPDB 32 0.42 3Q60-A nrPDB 32 0.45 4H05-A nrPDB 32 0.50 6G38-A nrPDB 32 0.52 6DFL-A nrPDB 31 1.2 2PZ1-A nrPDB 31 1.3 >2RSV-A nrPDB Length = 403 Score = 532 bits (1371), Expect = e-152, Method: Composition-based stats. Identities = 396/396 (100%), Positives = 396/396 (100%) Query: 1 MPRVKAAQAGRQSSAKRHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSE 60 MPRVKAAQAGRQSSAKRHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSE Sbjct: 8 MPRVKAAQAGRQSSAKRHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSE 67 Query: 61 SVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHD 120 SVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHD Sbjct: 68 SVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHD 127 Query: 121 KNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKA 180 KNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKA Sbjct: 128 KNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKA 187 Query: 181 SNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSR 240 SNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSR Sbjct: 188 SNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSR 247 Query: 241 RGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIA 300 RGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIA Sbjct: 248 RGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIA 307 Query: 301 KYMETVKLLDYTEKPLYENLRDILLQGLKAIGSKDDGKLDLSVVENGGLKAKTITKKRKK 360 KYMETVKLLDYTEKPLYENLRDILLQGLKAIGSKDDGKLDLSVVENGGLKAKTITKKRKK Sbjct: 308 KYMETVKLLDYTEKPLYENLRDILLQGLKAIGSKDDGKLDLSVVENGGLKAKTITKKRKK 367 Query: 361 EIEESKEPGVEDTEWSNTQTEEAIQTRSRTRKRVQK 396 EIEESKEPGVEDTEWSNTQTEEAIQTRSRTRKRVQK Sbjct: 368 EIEESKEPGVEDTEWSNTQTEEAIQTRSRTRKRVQK 403 >2LAV-A nrPDB Length = 361 Score = 460 bits (1183), Expect = e-130, Method: Composition-based stats. Identities = 361/361 (100%), Positives = 361/361 (100%) Query: 1 MPRVKAAQAGRQSSAKRHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSE 60 MPRVKAAQAGRQSSAKRHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSE Sbjct: 1 MPRVKAAQAGRQSSAKRHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSE 60 Query: 61 SVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHD 120 SVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHD Sbjct: 61 SVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHD 120 Query: 121 KNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKA 180 KNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKA Sbjct: 121 KNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKA 180 Query: 181 SNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSR 240 SNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSR Sbjct: 181 SNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSR 240 Query: 241 RGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIA 300 RGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIA Sbjct: 241 RGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIA 300 Query: 301 KYMETVKLLDYTEKPLYENLRDILLQGLKAIGSKDDGKLDLSVVENGGLKAKTITKKRKK 360 KYMETVKLLDYTEKPLYENLRDILLQGLKAIGSKDDGKLDLSVVENGGLKAKTITKKRKK Sbjct: 301 KYMETVKLLDYTEKPLYENLRDILLQGLKAIGSKDDGKLDLSVVENGGLKAKTITKKRKK 360 Query: 361 E 361 E Sbjct: 361 E 361 >4TN6-A nrPDB Length = 318 Score = 336 bits (861), Expect = 1e-92, Method: Composition-based stats. Identities = 89/326 (27%), Positives = 148/326 (45%), Gaps = 27/326 (8%) Query: 33 AKKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAA 91 +++G IG G FG IYL D+ + E V CV P L E K Y+ Sbjct: 5 VGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHP----QLHIESKIYK--- 57 Query: 92 KPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSR 151 +Q + +++ G Y M+M+ G L+ ++ +++FS Sbjct: 58 ---MMQGGVGIPTIRWCG------------AEGDYNVMVMELLGPSLEDLFNFCSRKFSL 102 Query: 152 KTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLN-YKNPDQVYLVDYGLAYRYCPEGVH 210 KTVL L+ +++ +EYIH ++H D+K N L+ K + VY++D+GLA +Y H Sbjct: 103 KTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTH 162 Query: 211 KEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKY 270 + + GT + SI+ H G+ SRR DLE LGY ++ + G LPW+ K Sbjct: 163 QHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKR 222 Query: 271 VRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDILLQGLKA 330 + +I ++ + C K P E A Y+ + L + +KP Y LR + Sbjct: 223 QKYERISEKKMSTPIEVLC---KGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHR 279 Query: 331 IGSKDDGKLDLSVVENGGLKAKTITK 356 G D D ++++ G +A + + Sbjct: 280 QGFSYDYVFDWNMLKFGASRAALVPR 305 >5UU1-A nrPDB Length = 324 Score = 318 bits (815), Expect = 3e-87, Method: Composition-based stats. Identities = 170/303 (56%), Positives = 217/303 (71%), Gaps = 3/303 (0%) Query: 22 QFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLF 81 F G+++ DM +W +G IG GGFG IYLA + DA VVKVE +NGPLF Sbjct: 3 PFPEGKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNKPE--KDARHVVKVEYQENGPLF 60 Query: 82 TELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKI 141 +ELKFYQR AK + I+KWI ++L YLG+P ++GSGL + G+SYRFM+M+R G DLQKI Sbjct: 61 SELKFYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKI 120 Query: 142 YEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 N F + TVLQL +R+LD+LEYIHE+EYVHGDIKA+NLLL YKNPDQVYL DYGL+ Sbjct: 121 SGQNG-TFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLS 179 Query: 202 YRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPW 261 YRYCP G HK+Y+E+P++ H+GTIEFTS+DAH GVA SRR D+EILGYCM++WL G LPW Sbjct: 180 YRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPW 239 Query: 262 EDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLR 321 E NLKDP V+ +K + + + K P + EIA+++ L Y EKP Y+ L+ Sbjct: 240 EQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALK 299 Query: 322 DIL 324 IL Sbjct: 300 KIL 302 >4NT4-A nrPDB Length = 312 Score = 314 bits (804), Expect = 5e-86, Method: Composition-based stats. Identities = 87/324 (26%), Positives = 146/324 (45%), Gaps = 25/324 (7%) Query: 24 AVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEP--SDNGPLF 81 A+ + M ++VG IG G FG + L +++ ++ +K+EP S L Sbjct: 1 AMDPMAVLMVGPNFRVGKKIGCGNFGELRL-----GKNLYNNEHVAIKMEPMKSKAPQLH 55 Query: 82 TELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKI 141 E +FY+ G+P+ + G G Y M+++ G L+ + Sbjct: 56 LEYRFYKLLGS---------HADNAPDGIPRIYHLGTC---GGRYNAMVLELLGLSLEDL 103 Query: 142 YEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLN---YKNPDQVYLVDY 198 + A++FS KTVL ++ ++L +EY+H ++ D+K N L+ K ++++D+ Sbjct: 104 FNICARKFSLKTVLMIAKQLLHRIEYVHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDF 163 Query: 199 GLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGH 258 GLA Y ++ + GT + SI+ H G SRR DLE LG+ + +L G Sbjct: 164 GLAKEYIDLDTNRHIPYREHKSLTGTARYMSINTHMGREQSRRDDLEALGHMFMYFLRGS 223 Query: 259 LPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYE 318 LPW+ D R KI + + C P E A Y+ V+ LD+ E P Y+ Sbjct: 224 LPWQGLKADTLKERYQKIGDTKRATPIEVLC---DGHPEEFATYLRYVRRLDFFETPDYD 280 Query: 319 NLRDILLQGLKAIGSKDDGKLDLS 342 LR + G D+G+ D + Sbjct: 281 FLRRLFQDLFDRKGYTDEGEFDWT 304 >3SV0-A nrPDB Length = 483 Score = 313 bits (802), Expect = 7e-86, Method: Composition-based stats. Identities = 84/327 (25%), Positives = 150/327 (45%), Gaps = 27/327 (8%) Query: 33 AKKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAA 91 ++++G IG G FG IYL ++ ++E V V P L E K Y+ Sbjct: 5 VGNKFRLGRKIGSGSFGEIYLGTNIQTNEEVAIKLENVKTKHP----QLLYESKIYR--- 57 Query: 92 KPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSR 151 +Q +++ GV Y ++MD G L+ ++ +++ S Sbjct: 58 ---ILQGGTGIPNVRWFGVE------------GDYNVLVMDLLGPSLEDLFNFCSRKLSL 102 Query: 152 KTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLN-YKNPDQVYLVDYGLAYRYCPEGVH 210 KTVL L+ ++++ +E++H ++H DIK N L+ + +QVY++D+GLA +Y H Sbjct: 103 KTVLMLADQMINRVEFVHSKSFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDTSTH 162 Query: 211 KEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKY 270 + + GT + S++ H G+ SRR DLE LGY ++ +L G LPW+ K Sbjct: 163 QHIPYRENKNLTGTARYASVNTHLGIEQSRRDDLESLGYVLMYFLRGSLPWQGLKAGTKK 222 Query: 271 VRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDILLQGLKA 330 + KI ++ S+ C + P E A Y + L + +KP Y L+ + Sbjct: 223 QKYEKISEKKVATSIEALC---RGYPTEFASYFHYCRSLRFDDKPDYSYLKRLFRDLFIR 279 Query: 331 IGSKDDGKLDLSVVENGGLKAKTITKK 357 G + D D ++++ + + + Sbjct: 280 EGFQFDYVFDWTILKYQQSQIASAPPR 306 >2C47-A nrPDB Length = 313 Score = 307 bits (787), Expect = 4e-84, Method: Composition-based stats. Identities = 86/313 (27%), Positives = 145/313 (46%), Gaps = 31/313 (9%) Query: 34 KKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEP--SDNGPLFTELKFYQRAA 91 ++VG IG G FG + L +++ ++ +K+EP S L E +FY++ + Sbjct: 3 GPNFRVGKKIGCGNFGELRL-----GKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLS 57 Query: 92 KPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSR 151 E GVP+ + G K Y M+++ G L+ +++ + F+ Sbjct: 58 ATE--------------GVPQVYYFGPCGK----YNAMVLELLGPSLEDLFDLCDRTFTL 99 Query: 152 KTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLN---YKNPDQVYLVDYGLAYRYCPEG 208 KTVL ++++++ +EY+H ++ D+K N L+ K ++++D+GLA Y Sbjct: 100 KTVLMIAIQLITRMEYVHTKSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPE 159 Query: 209 VHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDP 268 K + GT + SI+ H G SRR DLE LG+ + +L G LPW+ D Sbjct: 160 TKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADT 219 Query: 269 KYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDILLQGL 328 R KI + + C +N P E+A Y+ V+ LD+ EKP Y+ LR + Sbjct: 220 LKERYQKIGDTKRATPIEVLC---ENFPEEMATYLRYVRRLDFFEKPDYDYLRKLFTDLF 276 Query: 329 KAIGSKDDGKLDL 341 G D + D Sbjct: 277 DRSGFVFDYEYDW 289 >2CHL-A nrPDB Length = 351 Score = 307 bits (787), Expect = 4e-84, Method: Composition-based stats. Identities = 86/327 (26%), Positives = 146/327 (44%), Gaps = 32/327 (9%) Query: 20 AEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEP--SDN 77 E + M ++VG IG G FG + L +++ ++ +K+EP S Sbjct: 15 TENLYFQSMGVLMVGPNFRVGKKIGCGNFGELRL-----GKNLYTNEYVAIKLEPMKSRA 69 Query: 78 GPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSD 137 L E +FY++ + G+P+ + G K Y M+++ G Sbjct: 70 PQLHLEYRFYKQLGSGD--------------GIPQVYYFGPCGK----YNAMVLELLGPS 111 Query: 138 LQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLN---YKNPDQVY 194 L+ +++ + FS KTVL ++++++ +EY+H ++ D+K N L+ K ++ Sbjct: 112 LEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIH 171 Query: 195 LVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQW 254 ++D+ LA Y K + GT + SI+ H G SRR DLE LG+ + + Sbjct: 172 IIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYF 231 Query: 255 LTGHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEK 314 L G LPW+ D R KI + + C +N P E+A Y+ V+ LD+ EK Sbjct: 232 LRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLC---ENFP-EMATYLRYVRRLDFFEK 287 Query: 315 PLYENLRDILLQGLKAIGSKDDGKLDL 341 P Y+ LR + G D + D Sbjct: 288 PDYDYLRKLFTDLFDRKGYMFDYEYDW 314 >5FQD-C nrPDB Length = 341 Score = 307 bits (786), Expect = 5e-84, Method: Composition-based stats. Identities = 88/346 (25%), Positives = 158/346 (45%), Gaps = 36/346 (10%) Query: 9 AGRQSSAKRHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPC 68 GR +S+ AE + ++K+ IG G FG IYLA ++ + Sbjct: 2 GGRMASSSGSKAE---------FIVGGKYKLVRKIGSGSFGDIYLAI-----NITNGEEV 47 Query: 69 VVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKY-LGVPKYWGSGLHDKNGKSYR 127 VK+E Q+A P+ + + + L+ +G+P G K Y Sbjct: 48 AVKLES-------------QKARHPQLLYESKLYKILQGGVGIPHIRWYG----QEKDYN 90 Query: 128 FMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY 187 ++MD G L+ ++ ++RF+ KTVL L+ +++ +EY+H ++H DIK N L+ Sbjct: 91 VLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGI 150 Query: 188 -KNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEI 246 ++ ++++L+D+GLA +Y + + GT + SI+AH G+ SRR D+E Sbjct: 151 GRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMES 210 Query: 247 LGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETV 306 LGY ++ + LPW+ K + KI ++ + C K P E A Y+ Sbjct: 211 LGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLC---KGFPAEFAMYLNYC 267 Query: 307 KLLDYTEKPLYENLRDILLQGLKAIGSKDDGKLDLSVVENGGLKAK 352 + L + E P Y LR + + + + D D ++++ + Sbjct: 268 RGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQA 313 >2CMW-A nrPDB Length = 310 Score = 306 bits (783), Expect = 1e-83, Method: Composition-based stats. Identities = 86/309 (27%), Positives = 143/309 (46%), Gaps = 30/309 (9%) Query: 38 KVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEP--SDNGPLFTELKFYQRAAKPEQ 95 +VG IG G FG + L +++ ++ +K+EP S L E +FY++ + Sbjct: 3 RVGKKIGCGNFGELRL-----GKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLGSAGE 57 Query: 96 IQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVL 155 G+P+ + G K Y M+++ G L+ +++ + F+ KTVL Sbjct: 58 -------------GLPQVYYFGPCGK----YNAMVLELLGPSLEDLFDLCDRTFTLKTVL 100 Query: 156 QLSLRILDILEYIHEHEYVHGDIKASNLLLN---YKNPDQVYLVDYGLAYRYCPEGVHKE 212 +++++L +EY+H ++ D+K N L+ K ++++D+GLA Y K Sbjct: 101 MIAIQLLSRMEYVHSKNLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKH 160 Query: 213 YKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVR 272 + GT + SI+ H G SRR DLE LG+ + +L G LPW+ D R Sbjct: 161 IPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKER 220 Query: 273 DSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDILLQGLKAIG 332 KI + + C +N P E+A Y+ V+ LD+ EKP YE LR + + G Sbjct: 221 YQKIGDTKRNTPIEALC---ENFPEEMATYLRYVRRLDFFEKPDYEYLRTLFTDLFEKKG 277 Query: 333 SKDDGKLDL 341 D D Sbjct: 278 YTFDYAYDW 286 >1CSN-A nrPDB Length = 298 Score = 292 bits (747), Expect = 2e-79, Method: Composition-based stats. Identities = 82/319 (25%), Positives = 144/319 (45%), Gaps = 31/319 (9%) Query: 31 DMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRA 90 ++ +KVG IG+G FG I+ ++ ++ +K EP R Sbjct: 6 NVVGVHYKVGRRIGEGSFGVIF-----EGTNLLNNQQVAIKFEP--------------RR 46 Query: 91 AKPEQIQKWIRTRKL--KYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKR 148 + Q++ RT KL G+P + G + +++D G L+ + + ++ Sbjct: 47 SDAPQLRDEYRTYKLLAGCTGIPNVYYFG----QEGLHNVLVIDLLGPSLEDLLDLCGRK 102 Query: 149 FSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLL---NYKNPDQVYLVDYGLAYRYC 205 FS KTV + ++L ++ IHE V+ DIK N L+ N KN + +Y+VD+G+ Y Sbjct: 103 FSVKTVAMAAKQMLARVQSIHEKSLVYRDIKPDNFLIGRPNSKNANMIYVVDFGMVKFYR 162 Query: 206 PEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNL 265 + K+ GT + SI+ H G SRR DLE LG+ + +L G LPW+ Sbjct: 163 DPVTKQHIPYREKKNLSGTARYMSINTHLGREQSRRDDLEALGHVFMYFLRGSLPWQGLK 222 Query: 266 KDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDILL 325 + +I ++ L + C P E KYM + L + P Y+ L+ + Sbjct: 223 AATNKQKYERIGEKKQSTPLRELCA---GFPEEFYKYMHYARNLAFDATPDYDYLQGLFS 279 Query: 326 QGLKAIGSKDDGKLDLSVV 344 + L+ + + +D D +++ Sbjct: 280 KVLERLNTTEDENFDWNLL 298 >2JII-A nrPDB Length = 352 Score = 283 bits (723), Expect = 1e-76, Method: Composition-based stats. Identities = 112/315 (35%), Positives = 172/315 (54%), Gaps = 8/315 (2%) Query: 21 EQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAP---CVVKVEPSDN 77 E G ++TD + ++WK+ + G +Y A S+ + S +K++ D Sbjct: 28 EALPTGTVLTDKSGRQWKLKSFQTRDNQGILYEAAPTSTLTCDSGPQKQKFSLKLDAKD- 86 Query: 78 GPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSD 137 G LF E F+QRAAKP Q+ KW + L +P G G+H YRF+++ G Sbjct: 87 GRLFNEQNFFQRAAKPLQVNKWKKLYSTPLLAIPTCMGFGVHQDK---YRFLVLPSLGRS 143 Query: 138 LQKIYEANAKR-FSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLV 196 LQ + + K S ++VLQ++ R+LD LE++HE+EYVHG++ A N+ ++ ++ QV L Sbjct: 144 LQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVDPEDQSQVTLA 203 Query: 197 DYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT 256 YG A+RYCP G H Y E + H+G +EF S+D H G PSRR DL+ LGYCM++WL Sbjct: 204 GYGFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMDLHKGCGPSRRSDLQSLGYCMLKWLY 263 Query: 257 GHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPL 316 G LPW + L + + + K ++ + + C + KY++ V L Y EKP Sbjct: 264 GFLPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGHWIRPSETLQKYLKVVMALTYEEKPP 323 Query: 317 YENLRDILLQGLKAI 331 Y LR+ L L+ + Sbjct: 324 YAMLRNNLEALLQDL 338 >5X18-A nrPDB Length = 295 Score = 277 bits (707), Expect = 7e-75, Method: Composition-based stats. Identities = 79/315 (25%), Positives = 150/315 (47%), Gaps = 31/315 (9%) Query: 32 MAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAA 91 + +K+G IG+G FG ++ ++ + P +K EP R Sbjct: 4 IVGLHYKIGKKIGEGSFGVLF-----EGTNMINGVPVAIKFEP--------------RKT 44 Query: 92 KPEQIQKWIRTRKLKY--LGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRF 149 + Q++ +T K+ +P + G + +++D G L+ +++ ++F Sbjct: 45 EAPQLRDEYKTYKILNGTPNIPYAYYFG----QEGLHNILVIDLLGPSLEDLFDWCGRKF 100 Query: 150 SRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYK---NPDQVYLVDYGLAYRYCP 206 S KTV+Q++++++ ++E +H H+ ++ DIK N L+ + + ++L+D+G+A +Y Sbjct: 101 SVKTVVQVAVQMITLIEDLHAHDLIYRDIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRD 160 Query: 207 EGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLK 266 + K+ GT + SI+ H G SRR D+E LG+ +L GHLPW+ Sbjct: 161 PKTKQHIPYREKKSLSGTARYMSINTHLGREQSRRDDMEALGHVFFYFLRGHLPWQGLKA 220 Query: 267 DPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDILLQ 326 + KI ++ ++ D + P + +Y+E V+ L + E P YE R +LL Sbjct: 221 PNNKQKYEKIGEKKRSTNVYDL---AQGLPVQFGRYLEIVRSLSFEECPDYEGYRKLLLS 277 Query: 327 GLKAIGSKDDGKLDL 341 L +G DG+ D Sbjct: 278 VLDDLGETADGQYDW 292 >4XHH-A nrPDB Length = 403 Score = 270 bits (691), Expect = 6e-73, Method: Composition-based stats. Identities = 79/316 (25%), Positives = 142/316 (44%), Gaps = 27/316 (8%) Query: 33 AKKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAA 91 +++++G IG G FG IY ++ S E V + S + L E + Y+ + Sbjct: 5 VGRKFRIGRKIGSGSFGDIYHGTNLISGEEVAIRLESI----RSRHPQLDYESRVYKYLS 60 Query: 92 KPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSR 151 +G+P G Y M++D G L+ ++ ++FS Sbjct: 61 --------------GGVGIPFIRWFG----REGEYNAMVIDLLGPSLEDLFNYCHRKFSF 102 Query: 152 KTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY-KNPDQVYLVDYGLAYRYCPEGVH 210 KTV+ L+L+++ ++YIH ++H DIK N L+ + V+++D+GL+ +Y H Sbjct: 103 KTVIMLALQMICRVQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTH 162 Query: 211 KEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKY 270 + + GT + S++ H G+ SRR DLE LGY +I + G LPW+ K Sbjct: 163 RHIPYRENKSLTGTARYASVNTHLGIEQSRRDDLESLGYMLIYFCKGSLPWQGLKATTKK 222 Query: 271 VRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDILLQGLKA 330 + +I ++ S+ C P E ++YM + L + E+P Y L + Sbjct: 223 QKYDRILEKKLCISVETLCA---GLPLEFSEYMNYCRNLKFDERPDYLYLARLFKDLSIK 279 Query: 331 IGSKDDGKLDLSVVEN 346 + +D D +++ Sbjct: 280 LEYHNDHLFDWTMLRY 295 >4XHL-A nrPDB Length = 394 Score = 270 bits (690), Expect = 8e-73, Method: Composition-based stats. Identities = 86/334 (25%), Positives = 147/334 (44%), Gaps = 30/334 (8%) Query: 33 AKKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAA 91 +++++G IG G FG IY ++ S E V + S + L E + Y+ + Sbjct: 5 VGRKFRIGRKIGSGSFGDIYHGTNLISGEEVAIRLESI----RSRHPQLDYESRVYRYLS 60 Query: 92 KPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSR 151 +G+P G Y M++D G L+ ++ +RFS Sbjct: 61 --------------GGVGIPFIRWFG----REGEYNAMVIDLLGPSLEDLFNYCHRRFSF 102 Query: 152 KTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY-KNPDQVYLVDYGLAYRYCPEGVH 210 KTV+ L+L++ ++YIH ++H DIK N L+ + V+++D+GL+ +Y H Sbjct: 103 KTVIMLALQMFCRIQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTH 162 Query: 211 KEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKY 270 + + GT + S++ H G+ SRR DLE LGY +I + G LPW+ K Sbjct: 163 RHIPYRENKSLTGTARYASVNTHLGIEQSRRDDLESLGYVLIYFCKGSLPWQGLKATTKK 222 Query: 271 VRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDILLQGLKA 330 + +I ++ S+ C P E +YM K L + EKP Y L + Sbjct: 223 QKYDRIMEKKLNVSVETLC---SGLPLEFQEYMAYCKNLKFDEKPDYLFLARLFKDLSIK 279 Query: 331 IGSKDDGKLDLSVVENGGLKAKTITKKRKKEIEE 364 + +D D +++ + K+R IE+ Sbjct: 280 LEYHNDHLFDWTMLRY---TKAMVEKQRDLLIEK 310 >4NFN-A nrPDB Length = 309 Score = 230 bits (587), Expect = 7e-61, Method: Composition-based stats. Identities = 79/331 (23%), Positives = 140/331 (42%), Gaps = 38/331 (11%) Query: 17 RHLAEQFAVGEIITD--MAKKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVE 73 H++ +I+ + K WKV IG GGFG IY A D+ + E+V Sbjct: 1 GHMSGGGEQADILPANYVVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESA---- 56 Query: 74 PSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDR 133 L E+ ++ + V ++ G G ++K + +++M Sbjct: 57 QQPKQVLKMEVAVLKKLQGKD--------------HVCRFIGCGRNEK----FNYVVMQL 98 Query: 134 FGSDLQKIYEANAK-RFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY--KNP 190 G +L + + + F+ T L+L +IL+ +E IH ++H DIK SN + Sbjct: 99 QGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTY 158 Query: 191 DQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYC 250 + Y++D+GLA +Y + GT+ + S++AH R DL L Y Sbjct: 159 RKCYMLDFGLARQYTNTTGDVRPPRNVA-GFRGTVRYASVNAHKNREMGRHDDLWSLFYM 217 Query: 251 MIQWLTGHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLD 310 ++++ G LPW +KD + V K +Y + K+ P E +++ + LD Sbjct: 218 LVEFAVGQLPWR-KIKDKEQVGMIKEKYEHRMLL--------KHMPSEFHLFLDHIASLD 268 Query: 311 YTEKPLYENLRDILLQGLKAIGSKDDGKLDL 341 Y KP Y+ + + +K G ++ D Sbjct: 269 YFTKPDYQLIMSVFENSMKERGIAENEAFDW 299 >4BTK-A nrPDB Length = 337 Score = 230 bits (587), Expect = 7e-61, Method: Composition-based stats. Identities = 77/314 (24%), Positives = 134/314 (42%), Gaps = 36/314 (11%) Query: 32 MAKKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRA 90 + K WKV IG GGFG IY A D+ + E+V L E+ ++ Sbjct: 53 VVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESA----QQPKQVLKMEVAVLKKL 108 Query: 91 AKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAK-RF 149 + V ++ G G ++K + +++M G +L + + + F Sbjct: 109 QGKD--------------HVCRFIGCGRNEK----FNYVVMQLQGRNLADLRRSQPRGTF 150 Query: 150 SRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY--KNPDQVYLVDYGLAYRYCPE 207 + T L+L +IL+ +E IH ++H DIK SN + + Y++D+GLA +Y Sbjct: 151 TLSTTLRLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNT 210 Query: 208 GVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKD 267 + GT+ + S++AH R DL L Y ++++ G LPW +KD Sbjct: 211 TGDVRPPRNVA-GFRGTVRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWR-KIKD 268 Query: 268 PKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDILLQG 327 + V K +Y + K+ P E +++ + LDY KP Y+ + + Sbjct: 269 KEQVGMIKEKYEHRMLL--------KHMPSEFHLFLDHIASLDYFTKPDYQLIMSVFENS 320 Query: 328 LKAIGSKDDGKLDL 341 +K G ++ D Sbjct: 321 MKERGIAENEAFDW 334 >3DB8-A nrPDB Length = 317 Score = 218 bits (556), Expect = 3e-57, Method: Composition-based stats. Identities = 58/283 (20%), Positives = 107/283 (37%), Gaps = 35/283 (12%) Query: 4 VKAAQAGRQSSAKRHLAEQFAVGEIITDM-----AKKEWKVGLPIGQGGFG-CIYLADMN 57 + AA A + H+ + A + I D+ K + G +G+GGF C + DM+ Sbjct: 6 MSAAIAKPSAKPSAHVDPKSAPLKEIPDVLVDPRTMKRYMRGRFLGKGGFAKCYEITDMD 65 Query: 58 SSESVGSDA-PCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGS 116 + E P + ++P + TE+ ++ P + Sbjct: 66 TKEVFAGKVVPKSMLLKPHQKEKMSTEIAIHKSLDNPHVV-----------------GFH 108 Query: 117 GLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHG 176 G + + Y + + R S L+ K + + + ++Y+H + +H Sbjct: 109 GFFEDDDFVYVVLEICRRRSLLE--LHKRRKAVTEPEARYFMRQTIQGVQYLHNNRVIHR 166 Query: 177 DIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGV 236 D+K NL LN + V + D+GLA + E+ + K+ GT + + + Sbjct: 167 DLKLGNLFLN--DDMDVKIGDFGLATKI-------EFDGERKKDLCGTPNYIAPEVLCKK 217 Query: 237 APSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRYR 279 S D+ LG + L G P+E + Y+R K Y Sbjct: 218 GHSFEVDIWSLGCILYTLLVGKPPFETSCLKETYIRIKKNEYS 260 >5JN2-A nrPDB Length = 525 Score = 202 bits (512), Expect = 3e-52, Method: Composition-based stats. Identities = 59/312 (18%), Positives = 120/312 (38%), Gaps = 36/312 (11%) Query: 2 PRVKAAQAGRQSSAKRHL-AEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLA-DMNSS 59 PR + AG HL A + T + +K +G+G FG + L D + Sbjct: 33 PRSRGHAAGTSGGPGDHLHATPGMFVQHSTAIFSDRYKGQRVLGKGSFGEVILCKDKITG 92 Query: 60 ESVGSDAPCVVKV-EPSDNGPLFTELKFYQRAAKPE--QIQKWIRTRKLKYLGVPKYWGS 116 + +V + +D L E++ ++ P ++ ++ + YL Y G Sbjct: 93 QECAVKVISKRQVKQKTDKESLLREVQLLKQLDHPNIMKLYEFFEDKGYFYLVGEVYTGG 152 Query: 117 GLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHG 176 L D+ + KRFS ++ ++L + Y+H+++ VH Sbjct: 153 ELFDEI---------------------ISRKRFSEVDAARIIRQVLSGITYMHKNKIVHR 191 Query: 177 DIKASNLLLNYKNPD-QVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNG 235 D+K NLLL K+ D + ++D+GL+ + K+ GT + + + +G Sbjct: 192 DLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKD--------KIGTAYYIAPEVLHG 243 Query: 236 VAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNK 295 + D+ G + L+G P+ + + K +Y + K+ Sbjct: 244 TY-DEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFELPQWKKVSESAKDL 302 Query: 296 PGEIAKYMETVK 307 ++ Y+ +++ Sbjct: 303 IRKMLTYVPSMR 314 >3D2K-A nrPDB Length = 272 Score = 193 bits (489), Expect = 1e-49, Method: Composition-based stats. Identities = 51/247 (20%), Positives = 103/247 (41%), Gaps = 30/247 (12%) Query: 33 AKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAK 92 +++ +G P+G+G FG +YLA S+ + +KV LF ++A Sbjct: 10 TLEDFDIGRPLGKGKFGNVYLARERQSKFI-----LALKV-------LFKTQ--LEKAGV 55 Query: 93 PEQIQKWIRTR-KLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSR 151 Q+++ + + L++ + + +G HD + Y + G+ +++ + + RF Sbjct: 56 EHQLRREVEIQSHLRHPNILRLYG-YFHDAT-RVYLILEYAPLGTVYRELQKLS--RFDE 111 Query: 152 KTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHK 211 + + + L Y H +H DIK NLLL ++ + D+G + Sbjct: 112 QRTATYITELANALSYCHSKRVIHRDIKPENLLLGSNG--ELKIADFGWS---------V 160 Query: 212 EYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYV 271 + GT+++ + G + DL LG ++L G P+E + Y Sbjct: 161 HAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGMPPFEAHTYQETYR 220 Query: 272 RDSKIRY 278 R S++ + Sbjct: 221 RISRVEF 227 >4UZD-A nrPDB Length = 287 Score = 192 bits (488), Expect = 2e-49, Method: Composition-based stats. Identities = 52/247 (21%), Positives = 105/247 (42%), Gaps = 30/247 (12%) Query: 33 AKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAK 92 A +++++G P+G+G FG +YLA S+ + +KV LF ++A Sbjct: 6 ALEDFEIGRPLGKGKFGNVYLAREKQSKFI-----LALKV-------LFKAQ--LEKAGV 51 Query: 93 PEQIQKWIRTR-KLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSR 151 Q+++ + + L++ + + +G HD + Y + G+ +++ + + +F Sbjct: 52 EHQLRREVEIQSHLRHPNILRLYG-YFHDAT-RVYLILEYAPLGTVYRELQKLS--KFDE 107 Query: 152 KTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHK 211 + + + L Y H +H DIK NLLL ++ + D+G + Sbjct: 108 QRTATYITELANALSYCHSKRVIHRDIKPENLLLGS--AGELKIADFGWS---------V 156 Query: 212 EYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYV 271 + GT+++ + G + DL LG ++L G P+E N Y Sbjct: 157 HAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYK 216 Query: 272 RDSKIRY 278 R S++ + Sbjct: 217 RISRVEF 223 >4I6B-A nrPDB Length = 308 Score = 189 bits (479), Expect = 2e-48, Method: Composition-based stats. Identities = 63/303 (20%), Positives = 111/303 (36%), Gaps = 39/303 (12%) Query: 24 AVGEIITD-MAKKEWKVGLPIGQGGFG-CIYLADMNSSESVGSDAPCVVKVEPSDNGPLF 81 + II D K + G +G+GGF C + D+ +++ + K+ P Sbjct: 16 EISRIIVDPTTGKRYSRGKTLGKGGFAKCYEMTDLTNNKVYAA------KIIP------- 62 Query: 82 TELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKI 141 + R +KP Q +K + +L + K+ H K +++++ Sbjct: 63 -----HSRVSKPHQREKIDKEIELHRILHHKHVVQFYHYFEDKENIYILLEYCSRRSMAH 117 Query: 142 YEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 K + V +I+ L+Y+HE E +H D+K N +N ++ + D+GLA Sbjct: 118 ILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINES--MELKVGDFGLA 175 Query: 202 YRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPW 261 R P E +R GT + S + N D+ LG M L G P+ Sbjct: 176 ARLEP-------LEHRRRTICGTPNYLSPEVLNKQGHGAESDIWALGCVMYTMLLGRPPF 228 Query: 262 EDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNK-----PGEIAKYMETVKLLDYTE--- 313 E Y + RY +SL+ P + + ++ D+ Sbjct: 229 ETTNLKETYRSIREARY-TMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRH-DFFTQGF 286 Query: 314 KPL 316 P Sbjct: 287 TPD 289 >4JXF-A nrPDB Length = 266 Score = 182 bits (461), Expect = 2e-46, Method: Composition-based stats. Identities = 50/266 (18%), Positives = 102/266 (38%), Gaps = 34/266 (12%) Query: 24 AVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTE 83 +GE I D +KVG +G+G F +Y A ES+ + +K+ + Sbjct: 1 CIGEKIED-----FKVGNLLGKGSFAGVYRA-----ESIHTGLEVAIKM---------ID 41 Query: 84 LKFYQRAAKPEQIQKWIRTR-KLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKI 141 K +A +++Q ++ +LK+ + + + +Y +++++ ++ + Sbjct: 42 KKAMYKAGMVQRVQNEVKIHCQLKHPSILELYNY----FEDSNYVYLVLEMCHNGEMNRY 97 Query: 142 YEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 + K FS +I+ + Y+H H +H D+ SNLLL + + D+GLA Sbjct: 98 LKNRVKPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLT--RNMNIKIADFGLA 155 Query: 202 YRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPW 261 + + + GT + S + A D+ LG L G P+ Sbjct: 156 TQL-------KMPHEKHYTLCGTPNYISPEIATRSAHGLESDVWSLGCMFYTLLIGRPPF 208 Query: 262 EDNLKDPKYVRDSKIRYRENIASLMD 287 + + + Y ++ Sbjct: 209 DTDTVKNTLNKVVLADYEMPSFLSIE 234 >3UTO-A nrPDB Length = 573 Score = 181 bits (458), Expect = 6e-46, Method: Composition-based stats. Identities = 50/264 (18%), Positives = 102/264 (38%), Gaps = 33/264 (12%) Query: 25 VGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTEL 84 EI D + + +G G FG ++ + + G++ + P + Sbjct: 147 PVEIKHDHVLDHYDIHEELGTGAFGVVHRV---TERATGNNFAAKFVMTPHE-------- 195 Query: 85 KFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF--GSDLQKIY 142 + E ++K I+T + L P LHD +++ F G +L + Sbjct: 196 ------SDKETVRKEIQT--MSVLRHPTLVN--LHDAFEDDNEMVMIYEFMSGGELFEKV 245 Query: 143 EANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAY 202 + S ++ ++ L ++HE+ YVH D+K N++ K +++ L+D+GL Sbjct: 246 ADEHNKMSEDEAVEYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTA 305 Query: 203 RYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPW- 261 P+ + GT EF + + G D+ +G L+G P+ Sbjct: 306 HLDPKQ--------SVKVTTGTAEFAAPEVAEGKPVGYYTDMWSVGVLSYILLSGLSPFG 357 Query: 262 -EDNLKDPKYVRDSKIRYRENIAS 284 E++ + + V+ ++ S Sbjct: 358 GENDDETLRNVKSCDWNMDDSAFS 381 >1KOA-A nrPDB Length = 491 Score = 178 bits (452), Expect = 3e-45, Method: Composition-based stats. Identities = 50/264 (18%), Positives = 102/264 (38%), Gaps = 33/264 (12%) Query: 25 VGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTEL 84 EI D + + +G G FG ++ + + G++ + P + Sbjct: 41 PVEIKHDHVLDHYDIHEELGTGAFGVVHRV---TERATGNNFAAKFVMTPHE-------- 89 Query: 85 KFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF--GSDLQKIY 142 + E ++K I+T + L P LHD +++ F G +L + Sbjct: 90 ------SDKETVRKEIQT--MSVLRHPTLVN--LHDAFEDDNEMVMIYEFMSGGELFEKV 139 Query: 143 EANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAY 202 + S ++ ++ L ++HE+ YVH D+K N++ K +++ L+D+GL Sbjct: 140 ADEHNKMSEDEAVEYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTA 199 Query: 203 RYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPW- 261 P+ + GT EF + + G D+ +G L+G P+ Sbjct: 200 HLDPKQ--------SVKVTTGTAEFAAPEVAEGKPVGYYTDMWSVGVLSYILLSGLSPFG 251 Query: 262 -EDNLKDPKYVRDSKIRYRENIAS 284 E++ + + V+ ++ S Sbjct: 252 GENDDETLRNVKSCDWNMDDSAFS 275 >2OU7-A nrPDB Length = 335 Score = 176 bits (447), Expect = 1e-44, Method: Composition-based stats. Identities = 51/240 (21%), Positives = 92/240 (38%), Gaps = 30/240 (12%) Query: 42 PIGQGGFG-CIYLADMNSSESVGSD-APCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKW 99 +G+GGF C ++D ++ E P + ++P + E+ + Sbjct: 48 FLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIH------------ 95 Query: 100 IRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSL 159 R L + V + G + N + + + R S L+ K + Sbjct: 96 ---RSLAHQHVVGF--HGFFEDNDFVFVVLELCRRRSLLE--LHKRRKALTEPEARYYLR 148 Query: 160 RILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKR 219 +I+ +Y+H + +H D+K NL LN +V + D+GLA EY + K+ Sbjct: 149 QIVLGCQYLHRNRVIHRDLKLGNLFLNEDL--EVKIGDFGLA-------TKVEYDGERKK 199 Query: 220 CHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRYR 279 GT + + + + S D+ +G M L G P+E + Y+R K Y Sbjct: 200 VLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYS 259 >4J52-A nrPDB Length = 293 Score = 176 bits (447), Expect = 1e-44, Method: Composition-based stats. Identities = 51/240 (21%), Positives = 92/240 (38%), Gaps = 30/240 (12%) Query: 42 PIGQGGFG-CIYLADMNSSESVGSD-APCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKW 99 +G+GGF C ++D ++ E P + ++P + E+ + Sbjct: 21 FLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIH------------ 68 Query: 100 IRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSL 159 R L + V + G + N + + + R S L+ K + Sbjct: 69 ---RSLAHQHVVGF--HGFFEDNDFVFVVLELCRRRSLLE--LHKRRKALTEPEARYYLR 121 Query: 160 RILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKR 219 +I+ +Y+H + +H D+K NL LN +V + D+GLA EY + K+ Sbjct: 122 QIVLGCQYLHRNRVIHRDLKLGNLFLNEDL--EVKIGDFGLA-------TKVEYDGERKK 172 Query: 220 CHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRYR 279 GT + + + + S D+ +G M L G P+E + Y+R K Y Sbjct: 173 VLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYS 232 >3ORP-A nrPDB Length = 311 Score = 175 bits (444), Expect = 2e-44, Method: Composition-based stats. Identities = 53/257 (20%), Positives = 103/257 (40%), Gaps = 37/257 (14%) Query: 10 GRQSSAKRHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPC 68 G + HL++++ +GEI +G GG ++LA D+ V Sbjct: 1 GSHMTTPSHLSDRYELGEI--------------LGFGGMSEVHLARDLRDHRDVA----- 41 Query: 69 VVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRF 128 VKV +D L + FY R + Q L + + + +G + + Sbjct: 42 -VKVLRAD---LARDPSFYLRFRREAQ-----NAAALNHPAIVAVYDTGEAETPAGPLPY 92 Query: 129 MIMDRF-GSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY 187 ++M+ G L+ I + K +++ L + H++ +H D+K +N++++ Sbjct: 93 IVMEYVDGVTLRDIVHTEG-PMTPKRAIEVIADACQALNFSHQNGIIHRDVKPANIMISA 151 Query: 188 KNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEIL 247 N V ++D+G+A G GT ++ S + G + R D+ L Sbjct: 152 TN--AVKVMDFGIARAIADSGNSVT----QTAAVIGTAQYLSPEQARGDSVDARSDVYSL 205 Query: 248 GYCMIQWLTGHLPWEDN 264 G + + LTG P+ + Sbjct: 206 GCVLYEVLTGEPPFTGD 222 >4YZB-A nrPDB Length = 491 Score = 175 bits (442), Expect = 4e-44, Method: Composition-based stats. Identities = 56/302 (18%), Positives = 117/302 (38%), Gaps = 30/302 (9%) Query: 9 AGRQSSAKRHLA-EQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAP 67 +S LA + T +K +G+G FG + L + + Sbjct: 3 GSPAASKSDKLAATPGMFVQHSTAAFSDRYKGQRVLGKGSFGEVILC-----KDKVTGQE 57 Query: 68 CVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYR 127 VKV + Q+ K +++ +KL + + K + K Y Sbjct: 58 YAVKVISKR--------QVKQKTDKELLLKEVELLKKLDHPNIMKLYEF----FEDKGYF 105 Query: 128 FMIMD-RFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLN 186 +++ + G +L + KRFS ++ ++L + Y+H+++ VH D+K NLLL Sbjct: 106 YLVTEVYTGGELFDEI-ISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLE 164 Query: 187 YKNPD-QVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLE 245 K D + ++D+GL+ + K+ GT + + + +G + D+ Sbjct: 165 NKRKDANIRIIDFGLSTHFESTKKMKD--------KIGTAYYIAPEVLHGTY-DEKCDVW 215 Query: 246 ILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMET 305 G + L+G P+ + + K ++ ++ P K+ ++ Y+ T Sbjct: 216 STGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQWKKVSEPAKDLIRKMLAYVPT 275 Query: 306 VK 307 ++ Sbjct: 276 MR 277 >3MA6-A nrPDB Length = 298 Score = 175 bits (442), Expect = 4e-44, Method: Composition-based stats. Identities = 52/291 (17%), Positives = 112/291 (38%), Gaps = 35/291 (12%) Query: 22 QFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKV-EPSDNGP 79 + T + +K +G+G FG + L D + + +V + +D Sbjct: 19 PGMFVQHSTAIFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKES 78 Query: 80 LFTELKFYQRAAKPE--QIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSD 137 L E++ ++ P ++ ++ + YL Y G L D+ Sbjct: 79 LLREVQLLKQLDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEI--------------- 123 Query: 138 LQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPD-QVYLV 196 + KRFS ++ ++L + Y+H+++ VH D+K NLLL K+ D + ++ Sbjct: 124 ------ISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLESKSKDANIRII 177 Query: 197 DYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT 256 D+GL+ + K+ GT + + + +G + D+ G + L+ Sbjct: 178 DFGLSTHFEASKKMKD--------KIGTAYYIAPEVLHGTY-DEKCDVWSTGVILYILLS 228 Query: 257 GHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVK 307 G P+ + + K +Y + K+ ++ Y+ +++ Sbjct: 229 GCPPFNGANEYDILKKVEKGKYTFELPQWKKVSESAKDLIRKMLTYVPSMR 279 >1KOB-A nrPDB Length = 387 Score = 171 bits (434), Expect = 3e-43, Method: Composition-based stats. Identities = 53/272 (19%), Positives = 98/272 (36%), Gaps = 41/272 (15%) Query: 25 VGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVE----PSDNGPL 80 E+ + + +G G FG ++ + V K P D + Sbjct: 41 PVEVKQGSVYDYYDILEELGSGAFGVVHRCVEK-----ATGRVFVAKFINTPYPLDKYTV 95 Query: 81 FTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSY-RFMIMDRF-GSDL 138 E+ + P+ I LHD Y +I++ G +L Sbjct: 96 KNEISIMNQLHHPKLI--------------------NLHDAFEDKYEMVLILEFLSGGEL 135 Query: 139 QKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDY 198 A + S V+ + + L+++HEH VH DIK N++ K V ++D+ Sbjct: 136 FDRIAAEDYKMSEAEVINYMRQACEGLKHMHEHSIVHLDIKPENIMCETKKASSVKIIDF 195 Query: 199 GLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGH 258 GLA + P+ + + T EF + + + D+ +G L+G Sbjct: 196 GLATKLNPDEIV--------KVTTATAEFAAPEIVDREPVGFYTDMWAIGVLGYVLLSGL 247 Query: 259 LPW--EDNLKDPKYVRDSKIRYRENIASLMDK 288 P+ ED+L+ + V+ + E+ S + Sbjct: 248 SPFAGEDDLETLQNVKRCDWEFDEDAFSSVSP 279 >4B8L-A nrPDB Length = 286 Score = 171 bits (434), Expect = 4e-43, Method: Composition-based stats. Identities = 49/252 (19%), Positives = 100/252 (39%), Gaps = 30/252 (11%) Query: 33 AKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAK 92 ++ +G P+G+G FG +YLA ++ + +KV LF ++ Sbjct: 13 TIDDFDIGRPLGKGKFGNVYLAREKQNKFI-----MALKV-------LFKSQ--LEKEGV 58 Query: 93 PEQIQKWIRTR-KLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSR 151 Q+++ I + L++ + + + HD+ + Y + G +++ + RF Sbjct: 59 EHQLRREIEIQSHLRHPNILRMYN-YFHDRK-RIYLMLEFAPRGELYKELQK--HGRFDE 114 Query: 152 KTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHK 211 + + D L Y HE + +H DIK NLL+ YK ++ + D+G + Sbjct: 115 QRSATFMEELADALHYCHERKVIHRDIKPENLLMGYKG--ELKIADFGWS---------V 163 Query: 212 EYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYV 271 +R GT+++ + G + DL G ++L G P++ + Sbjct: 164 HAPSLRRRTMCGTLDYLPPEMIEGKTHDEKVDLWCAGVLCYEFLVGMPPFDSPSHTETHR 223 Query: 272 RDSKIRYRENIA 283 R + + Sbjct: 224 RIVNVDLKFPPF 235 >4B6L-A nrPDB Length = 281 Score = 170 bits (429), Expect = 1e-42, Method: Composition-based stats. Identities = 54/296 (18%), Positives = 97/296 (32%), Gaps = 34/296 (11%) Query: 28 IITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFY 87 I + + + G +G+GGF Y A + + VKV P Sbjct: 2 ITDPRSGRTYLKGRLLGKGGFARCYEATDTET-----GSAYAVKVIPQS----------- 45 Query: 88 QRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAK 147 R AKP Q +K + +L ++ H ++ ++ Sbjct: 46 -RVAKPHQREKILNEIELHRDLQHRHIVRFSHHFEDADNIYIFLELCSRKSLAHIWKARH 104 Query: 148 RFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPE 207 V +IL L+Y+H+ +H D+K N + ++ + D+GLA R P Sbjct: 105 TLLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFITEN--MELKVGDFGLAARLEP- 161 Query: 208 GVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKD 267 E K+ GT + + + D+ LG M L G P+E Sbjct: 162 ------PEQRKKTICGTPNYVAPEVLLRQGHGPEADVWSLGCVMYTLLCGSPPFETADLK 215 Query: 268 PKYVRDSKIRYRENIASLM----DKCFPEKNKPGEIAKYMETVKLLDYTEK---PL 316 Y ++ Y + + + P + + ++ D+ K P Sbjct: 216 ETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPSIDQILRH-DFFTKGYTPD 270 >3Q5I-A nrPDB Length = 504 Score = 168 bits (425), Expect = 4e-42, Method: Composition-based stats. Identities = 63/352 (17%), Positives = 120/352 (34%), Gaps = 24/352 (6%) Query: 22 QFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLF 81 + + +G G +G + L + S A V+K D G Sbjct: 23 PGMYVRKKEGKIGESYFKVRKLGSGAYGEVLLCKEKNGHS--EKAIKVIKKSQFDKGRYS 80 Query: 82 TELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKI 141 + K ++ E + + L + + K + K Y +++ + + Sbjct: 81 DDNKNIEKF-HEEIYNEISLLKSLDHPNIIKLFDV----FEDKKYFYLVTEFYEGGELFE 135 Query: 142 YEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNP-DQVYLVDYGL 200 N +F + +IL + Y+H+H VH DIK N+LL KN + +VD+GL Sbjct: 136 QIINRHKFDECDAANIMKQILSGICYLHKHNIVHRDIKPENILLENKNSLLNIKIVDFGL 195 Query: 201 AYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLP 260 + + K+YK + GT + + + + + D+ G M L G+ P Sbjct: 196 SSFFS-----KDYKLRDRL---GTAYYIAPEVLKKKY-NEKCDVWSCGVIMYILLCGYPP 246 Query: 261 WEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENL 320 + + K +Y + + K + Y + K E + Sbjct: 247 FGGQNDQDIIKKVEKGKYYFDFNDWKNISDEAKELIKLMLTY-DYNKRCTAEEALNSRWI 305 Query: 321 RDILLQGLKAIGSKDDGKLDLSVVENGGLK-----AKTITKKRKKEIEESKE 367 + K+ G L ++ + G + A + +EE KE Sbjct: 306 KKYANNINKSDQKTLCGALS-NMRKFEGSQKLAQAAILFIGSKLTTLEERKE 356 >5LOH-A nrPDB Length = 341 Score = 168 bits (425), Expect = 4e-42, Method: Composition-based stats. Identities = 51/271 (18%), Positives = 97/271 (35%), Gaps = 26/271 (9%) Query: 9 AGRQSSAKRHLAEQFAVGEIITDM--AKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDA 66 AG + A + V I + +E+ + PI +G FG +YL Sbjct: 8 AGSKKEPGGGAATEEGVNRIAVPKPPSIEEFSIVKPISRGAFGKVYLGQ-------KGGK 60 Query: 67 PCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSY 126 VKV + Q+Q L + + + Sbjct: 61 LYAVKVVKKAD---------MINKNMTHQVQAERDALALSK---SPFIVHLYYSLQSANN 108 Query: 127 RFMIMDRF-GSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLL 185 +++M+ G D++ + F + ++ + L+Y+H H +H D+K N+L+ Sbjct: 109 VYLVMEYLIGGDVKSLLHIYG-YFDEEMAVKYISEVALALDYLHRHGIIHRDLKPDNMLI 167 Query: 186 NYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLE 245 + + + L D+GL+ ++ R GT ++ + + G A D Sbjct: 168 SNEG--HIKLTDFGLSKVTLNRDINM-MDILTTRTFCGTPDYLAPELLLGRAHGPAVDWW 224 Query: 246 ILGYCMIQWLTGHLPWEDNLKDPKYVRDSKI 276 LG C+ ++LTG P+ D + K Sbjct: 225 ALGVCLFEFLTGIPPFNDETPQQVFQNILKR 255 >5XZW-A nrPDB Length = 471 Score = 167 bits (422), Expect = 8e-42, Method: Composition-based stats. Identities = 53/295 (17%), Positives = 101/295 (34%), Gaps = 42/295 (14%) Query: 3 RVKAAQAGRQSSAKRHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESV 62 R + +S + ++ T + K + +GQG F + A ++ Sbjct: 164 RSNLKNTSKIASPGLTSSTASSMVANKTGIFKDFSIIDEVVGQGAFATVKKAIERTTGKT 223 Query: 63 GSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKN 122 + + + + EL+ Q+ L + + + G Sbjct: 224 FAVKIISKRKVIGNMDGVTRELEVLQK---------------LNHPRIVRLKGFY----E 264 Query: 123 GKSYRFMIMDRF-GSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKAS 181 +M+M+ G DL A+ ++S +IL ++YIH H D+K Sbjct: 265 DTESYYMVMEFVSGGDLMDFVAAHGA-VGEDAGREISRQILTAIKYIHSMGISHRDLKPD 323 Query: 182 NLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGV----- 236 N+L+ +P V + D+GLA + GT+ + + + G Sbjct: 324 NILIEQDDPVLVKITDFGLAKVQGNGSFM--------KTFCGTLAYVAPEVIRGKDTSVS 375 Query: 237 --------APSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRYRENIA 283 S D+ +G + LTGHLP+ + +D Y + + Y E Sbjct: 376 PDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRGSYHEGPL 430 >3HZT-A nrPDB Length = 467 Score = 166 bits (419), Expect = 2e-41, Method: Composition-based stats. Identities = 63/347 (18%), Positives = 123/347 (35%), Gaps = 47/347 (13%) Query: 34 KKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEP----SDNGPLFTELKFYQR 89 ++ +G G +G + L + A ++K S++G L E+ ++ Sbjct: 3 SDRYQRVKKLGSGAYGEVLLC--KDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQ 60 Query: 90 AAKPE--QIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAK 147 P ++ ++ ++ YL + Y G L D+ +I+ + Sbjct: 61 LDHPNIMKLYEFFEDKRNYYLVMEVYRGGELFDE-------IIL--------------RQ 99 Query: 148 RFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQ-VYLVDYGLAYRYCP 206 +FS + ++L Y+H+H VH D+K NLLL K+ D + +VD+GL+ + Sbjct: 100 KFSEVDAAVIMKQVLSGTTYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEV 159 Query: 207 EGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLK 266 G KE GT + + + + D+ G + L G+ P+ Sbjct: 160 GGKMKERL--------GTAYYIAPEVLRKKY-DEKCDVWSCGVILYILLCGYPPFGGQTD 210 Query: 267 DPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDILLQ 326 R K ++ + K + Y K + E + + Q Sbjct: 211 QEILKRVEKGKFSFDPPDWTQVSDEAKQLVKLMLTYEP-SKRISAEEALNHPWIVKFCSQ 269 Query: 327 GLKAIG-SKDDGKLDLSVVENGGLK-----AKTITKKRKKEIEESKE 367 +G G L ++ + + A + +EE+KE Sbjct: 270 KHTDVGKHALTGALG-NMKKFQSSQKLAQAAMLFMGSKLTTLEETKE 315 >1VZO-A nrPDB Length = 355 Score = 164 bits (415), Expect = 6e-41, Method: Composition-based stats. Identities = 56/289 (19%), Positives = 110/289 (38%), Gaps = 31/289 (10%) Query: 6 AAQAGRQSSAKRHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSD 65 G Q +H + + + +++ +G G +G ++L Sbjct: 25 GGDGGEQLLTVKHELRTANLTGHAEKVGIENFELLKVLGTGAYGKVFL------------ 72 Query: 66 APCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRK----LKYLGVPKYWGSGLHDK 121 V K+ D G L+ +K ++A ++ + TR L+++ + + + Sbjct: 73 ---VRKISGHDTGKLYA-MKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAF 128 Query: 122 NGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKAS 181 ++ +I+D + + +RF+ V I+ LE++H+ ++ DIK Sbjct: 129 QTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLE 188 Query: 182 NLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNG--VAPS 239 N+LL+ V L D+GL+ + + + Y GTIE+ + D G Sbjct: 189 NILLDSNG--HVVLTDFGLSKEFVADETERAYD------FCGTIEYMAPDIVRGGDSGHD 240 Query: 240 RRGDLEILGYCMIQWLTGHLPWE-DNLKDPKYVRDSKIRYRENIASLMD 287 + D LG M + LTG P+ D K+ + +I E Sbjct: 241 KAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEM 289 >4MVF-A nrPDB Length = 506 Score = 163 bits (412), Expect = 1e-40, Method: Composition-based stats. Identities = 45/245 (18%), Positives = 91/245 (37%), Gaps = 30/245 (12%) Query: 35 KEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPE 94 ++ + +GQG +GC+Y ++ +K E D L +F+Q Sbjct: 57 DKYIIDEKLGQGTYGCVYKGIDK-----VTNQLYAIKEEKKD--RLKNINRFFQ------ 103 Query: 95 QIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTV 154 + +KL + + K + + +D +Y ++IM+ F+ K Sbjct: 104 ---EIEIMKKLDHPNIVKLYETYEND----NYIYLIMELCSGRELFDSIIENGSFTEKNA 156 Query: 155 LQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQ-VYLVDYGLAYRYCPEGVHKEY 213 + +I + Y+H VH D+K N L +N D + ++D+GL+ Sbjct: 157 ATIMKQIFSAIFYLHSLNIVHRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEF---- 212 Query: 214 KEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRD 273 GT + + +G ++ D+ G M L G+ P+ + + + Sbjct: 213 ----TTTKAGTPYYVAPQVLDGKY-DKKCDIWSSGVIMYTLLCGYPPFYGDTDNEVLKKV 267 Query: 274 SKIRY 278 K + Sbjct: 268 KKGEF 272 >4PDS-A nrPDB Length = 347 Score = 163 bits (412), Expect = 1e-40, Method: Composition-based stats. Identities = 53/292 (18%), Positives = 100/292 (34%), Gaps = 42/292 (14%) Query: 6 AAQAGRQSSAKRHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSD 65 A + +S + ++ T + K + +GQG F + A ++ S Sbjct: 2 AMATSKIASPGLTSSTASSMVANKTGIFKDFSIIDEVVGQGAFATVKKAIERTTGKTFSV 61 Query: 66 APCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKS 125 + + + EL+ Q+ L + + + G Sbjct: 62 KIISKRKVIGNMDGVTRELEVLQK---------------LNHPRIVRLKGFY----EDTE 102 Query: 126 YRFMIMDRF-GSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLL 184 +M+M+ G DL A+ ++S +IL ++YIH H D+K N+L Sbjct: 103 SYYMVMEFVSGGDLMDFVAAHGA-VGEDAGREISRQILTAIKYIHSMGISHRDLKPDNIL 161 Query: 185 LNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGV-------- 236 + +P V + +GLA + GT+ + + + G Sbjct: 162 IEQDDPVLVKITAFGLAKVQGNGSFM--------KTFCGTLAYVAPEVIRGKDTSVSPDE 213 Query: 237 -----APSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRYRENIA 283 S D+ +G + LTGHLP+ + +D Y + + Y E Sbjct: 214 YEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRGSYHEGPL 265 >4AF3-A nrPDB Length = 292 Score = 163 bits (412), Expect = 1e-40, Method: Composition-based stats. Identities = 45/248 (18%), Positives = 96/248 (38%), Gaps = 30/248 (12%) Query: 33 AKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAK 92 ++++G P+G+G FG +YLA S + +KV LF ++ Sbjct: 21 TIDDFEIGRPLGKGKFGNVYLAREKKSHFI-----VALKV-------LFKSQ--IEKEGV 66 Query: 93 PEQIQKWIRTR-KLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSR 151 Q+++ I + L + + + + + Y + G +++ ++ F Sbjct: 67 EHQLRREIEIQAHLHHPNILRLYNY--FYDRRRIYLILEYAPRGELYKELQKSC--TFDE 122 Query: 152 KTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHK 211 + + + D L Y H + +H DIK N L ++ + D+G + Sbjct: 123 QRTATIMEELADALMYCHGKKVIHRDIKPEN--LLLGLKGELKIADFGWS---------V 171 Query: 212 EYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYV 271 ++ GT+++ + G + + DL +G + L G+ P+E + Y Sbjct: 172 HAPSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYR 231 Query: 272 RDSKIRYR 279 R K+ + Sbjct: 232 RIVKVDLK 239 >3DXN-A nrPDB Length = 287 Score = 163 bits (412), Expect = 1e-40, Method: Composition-based stats. Identities = 52/277 (18%), Positives = 101/277 (36%), Gaps = 39/277 (14%) Query: 34 KKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEP----SDNGPLFTELKFYQR 89 ++ +G G +G + L + A ++K S++G L E+ ++ Sbjct: 20 SDRYQRVKKLGSGAYGEVLLC--KDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQ 77 Query: 90 AAKPE--QIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAK 147 P ++ ++ ++ YL + Y G L D+ +I+ + Sbjct: 78 LDHPNIMKLYEFFEDKRNYYLVMEVYRGGELFDE-------IIL--------------RQ 116 Query: 148 RFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQ-VYLVDYGLAYRYCP 206 +FS + ++L Y+H+H VH D+K NLLL K+ D + +VD+GL+ + Sbjct: 117 KFSEVDAAVIMKQVLSGTTYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEV 176 Query: 207 EGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLK 266 G KE GT + + + + D+ G + L G+ P+ Sbjct: 177 GGKMKERL--------GTAYYIAPEVLRKKY-DEKCDVWSCGVILYILLCGYPPFGGQTD 227 Query: 267 DPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYM 303 R K ++ + K + Y Sbjct: 228 QEILKRVEKGKFSFDPPDWTQVSDEAKQLVKLMLTYE 264 >2BDW-A nrPDB Length = 362 Score = 161 bits (408), Expect = 4e-40, Method: Composition-based stats. Identities = 50/287 (17%), Positives = 89/287 (31%), Gaps = 41/287 (14%) Query: 2 PRVKAAQAGRQSSAKRHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNS-SE 60 P + + G+Q + + V +G+G F + + Sbjct: 2 PHMASMTGGQQMGRGS------EFMMNASTKFSDNYDVKEELGKGAFSVVRRCVHKTTGL 55 Query: 61 SVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHD 120 + K+ D L E + ++ P ++ LHD Sbjct: 56 EFAAKIINTKKLSARDFQKLEREARICRKLQHPNIVR--------------------LHD 95 Query: 121 K-NGKSYRFMIMDRF--GSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGD 177 +S+ +++ D G + I +S +IL+ + Y H + VH + Sbjct: 96 SIQEESFHYLVFDLVTGGELFEDIVARE--FYSEADASHCIQQILESIAYCHSNGIVHRN 153 Query: 178 IKASNLLLNYKNPDQ-VYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGV 236 +K NLLL K V L D+GLA GT + S + Sbjct: 154 LKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWH--------GFAGTPGYLSPEVLKKD 205 Query: 237 APSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRYRENIA 283 S+ D+ G + L G+ P+ D + Y + Y Sbjct: 206 PYSKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYDYPSP 252 >3LIJ-A nrPDB Length = 494 Score = 161 bits (406), Expect = 7e-40, Method: Composition-based stats. Identities = 45/285 (15%), Positives = 96/285 (33%), Gaps = 30/285 (10%) Query: 20 AEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNG 78 A + ++ +G G +G + L D + V S N Sbjct: 22 ATPGMFITSKKGHLSEMYQRVKKLGSGAYGEVLLCRDKVTHVERAIKIIRKTSVSTSSNS 81 Query: 79 PLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDL 138 L E+ + + + K + K +++M+ + Sbjct: 82 KLLEEVAVLKLLD---------------HPNIMKLYDF----FEDKRNYYLVMECYKGGE 122 Query: 139 QKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQ-VYLVD 197 + +F+ + ++L + Y+H+H VH D+K NLLL K D + +VD Sbjct: 123 LFDEIIHRMKFNEVDAAVIIKQVLSGVTYLHKHNIVHRDLKPENLLLESKEKDALIKIVD 182 Query: 198 YGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTG 257 +GL+ + + KE GT + + + + D+ +G + L G Sbjct: 183 FGLSAVFENQKKMKERL--------GTAYYIAPEVLRKKY-DEKCDVWSIGVILFILLAG 233 Query: 258 HLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKY 302 + P+ + K +Y + + K+ ++ ++ Sbjct: 234 YPPFGGQTDQEILRKVEKGKYTFDSPEWKNVSEGAKDLIKQMLQF 278 >4RGJ-A nrPDB Length = 520 Score = 160 bits (405), Expect = 7e-40, Method: Composition-based stats. Identities = 48/289 (16%), Positives = 111/289 (38%), Gaps = 30/289 (10%) Query: 22 QFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLF 81 + + +++K +G+G FG + L+ + +KV + Sbjct: 47 PGMFIQNSNVVFNEQYKGIKILGKGSFGEVILSRDK-----HTGHEYAIKVISKKHVK-- 99 Query: 82 TELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMD-RFGSDLQK 140 ++ K +++ + L ++ + K + +Y +++ D G +L Sbjct: 100 ------RKTDKESLLREVELLKMLDHINIMKLYEF----FEDNNYYYLVSDVYTGGELFD 149 Query: 141 IYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQ--VYLVDY 198 + KRF ++ +IL + Y+H++ VH D+K N+LL KN + + ++D+ Sbjct: 150 EI-ISRKRFYEIDAARIIKQILSGITYMHKNNVVHRDLKPENILLETKNKEDMIIKIIDF 208 Query: 199 GLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGH 258 GL+ + K+ GT + + D +G + D+ G + L+G Sbjct: 209 GLSTHFEYSKKMKD--------KIGTAYYIAPDVLHGTY-DEKCDIWSCGVILYILLSGC 259 Query: 259 LPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVK 307 P+ + + + +Y ++ K+ ++ Y V+ Sbjct: 260 PPFNGSNEYDILKKVEAGKYTFDLPQFKKISDKAKDLIKKMLMYTSAVR 308 >5ES1-A nrPDB Length = 328 Score = 160 bits (403), Expect = 1e-39, Method: Composition-based stats. Identities = 44/250 (17%), Positives = 91/250 (36%), Gaps = 31/250 (12%) Query: 36 EWKVGLPIGQGGFGCIYLAD-MNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPE 94 +++ IG+G F + LA + + V ++ PS LF E++ + Sbjct: 16 NYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMK------ 69 Query: 95 QIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTV 154 L + + K + +K +++M+ + Y + R K Sbjct: 70 ---------GLNHPNIVKLFEVIETEKT----LYLVMEYASAGEVFDYLVSHGRMKEKEA 116 Query: 155 LQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYK 214 +I+ + Y H+ VH D+KA NLLL+ + + + D+G + + Sbjct: 117 RAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAE--ANIKIADFGFSNEFT--------L 166 Query: 215 EDPKRCHDGTIEFTSIDAHNGVAP-SRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRD 273 G+ + + + G D+ LG + ++G LP++ + R Sbjct: 167 GSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERV 226 Query: 274 SKIRYRENIA 283 + +YR Sbjct: 227 LRGKYRVPFY 236 >3KK8-A nrPDB Length = 284 Score = 159 bits (401), Expect = 3e-39, Method: Composition-based stats. Identities = 47/257 (18%), Positives = 82/257 (31%), Gaps = 35/257 (13%) Query: 32 MAKKEWKVGLPIGQGGFGCIYLADMNS-SESVGSDAPCVVKVEPSDNGPLFTELKFYQRA 90 + V +G+G F + + + K+ D L E + ++ Sbjct: 3 KFSDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKL 62 Query: 91 AKPEQIQKWIRTRKLKYLGVPKYWGSGLHDK-NGKSYRFMIMDRF--GSDLQKIYEANAK 147 P ++ LHD +S+ +++ D G + I Sbjct: 63 QHPNIVR--------------------LHDSIQEESFHYLVFDLVTGGELFEDIVARE-- 100 Query: 148 RFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQ-VYLVDYGLAYRYCP 206 +S +IL+ + Y H + VH ++K NLLL K V L D+GLA Sbjct: 101 FYSEADASHCIQQILESIAYCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVND 160 Query: 207 EGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLK 266 GT + S + S+ D+ G + L G+ P+ D + Sbjct: 161 SEAWH--------GFAGTPGYLSPEVLKKDPYSKPVDIWACGVILYILLVGYPPFWDEDQ 212 Query: 267 DPKYVRDSKIRYRENIA 283 Y + Y Sbjct: 213 HRLYAQIKAGAYDYPSP 229 >6C9D-A nrPDB Length = 459 Score = 158 bits (400), Expect = 3e-39, Method: Composition-based stats. Identities = 62/381 (16%), Positives = 120/381 (31%), Gaps = 65/381 (17%) Query: 36 EWKVGLPIGQGGFGCIYLAD-MNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPE 94 +++ IG+G F + LA + + V ++ P+ LF E++ + Sbjct: 22 NYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMK------ 75 Query: 95 QIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTV 154 L + + K + +K +++M+ Y R K Sbjct: 76 ---------ILNHPNIVKLFEVIETEKT----LYLVMEYASGGEVFDYLVAHGRMKEKEA 122 Query: 155 LQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYK 214 +I+ ++Y H+ VH D+KA NLLL+ + + D+G + + E+ Sbjct: 123 RAKFRQIVSAVQYCHQKYIVHRDLKAENLLLD--GDMNIKIADFGFSNEFTVGNKLDEF- 179 Query: 215 EDPKRCHDGTIEFTSIDAHNGVAP-SRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRD 273 G+ + + + G D+ LG + ++G LP++ R Sbjct: 180 -------CGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERV 232 Query: 274 SKIRYRENIA----SLMDKCFPEKNKPGEIAKYMETVK-----------LLDYTEKPLYE 318 + +YR P + + +K L +P + Sbjct: 233 LRGKYRIPFYMSTDCENLLKKLLVLNPIKRGSLEQIMKDRWMNVGHEEEELKPYTEPDPD 292 Query: 319 NLRDILLQGLKAIGSKDDG--------KLDLSVVEN-----------GGLKAKTITKKRK 359 + + +G D K D + GG K+R Sbjct: 293 FNDTKRIDIMVTMGFARDEINDALINQKYDEVMATYILLGRKPPEFEGGESLSGEPKERD 352 Query: 360 KEIEESKEPGVEDTEWSNTQT 380 KE + +P WS T Sbjct: 353 KEEGKDSKPRSLRFTWSMKTT 373 >3IS5-A nrPDB Length = 285 Score = 158 bits (400), Expect = 3e-39, Method: Composition-based stats. Identities = 52/258 (20%), Positives = 96/258 (37%), Gaps = 34/258 (13%) Query: 35 KEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPE 94 + +G G FG ++L + SS V+K D + E Sbjct: 22 DLFIFKRKLGSGAFGDVHLVEERSS-----GLERVIKTINKDRSQVPME----------- 65 Query: 95 QIQKWIR-TRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEAN--AKRFSR 151 QI+ I + L + + K + + + Y M G L++I A K S Sbjct: 66 QIEAEIEVLKSLDHPNIIKIF--EVFEDYHNMYIVMETCEGGELLERIVSAQARGKALSE 123 Query: 152 KTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQ-VYLVDYGLAYRYCPEGVH 210 V +L ++++ L Y H VH D+K N+L +P + ++D+GLA + + Sbjct: 124 GYVAELMKQMMNALAYFHSQHVVHKDLKPENILFQDTSPHSPIKIIDFGLAELFKSDEHS 183 Query: 211 KEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKY 270 GT + + + + + D+ G M LTG LP+ + Sbjct: 184 T--------NAAGTALYMAPEVFK-RDVTFKCDIWSAGVVMYFLLTGCLPFTGTSLEEVQ 234 Query: 271 VRDSKIRYRENIASLMDK 288 + + Y+E ++ + Sbjct: 235 QKAT---YKEPNYAVECR 249 >2HAK-A nrPDB Length = 328 Score = 158 bits (399), Expect = 4e-39, Method: Composition-based stats. Identities = 43/250 (17%), Positives = 89/250 (35%), Gaps = 31/250 (12%) Query: 36 EWKVGLPIGQGGFGCIYLAD-MNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPE 94 +++ IG+G F + LA + + V ++ P+ LF E++ + Sbjct: 16 NYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMK------ 69 Query: 95 QIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTV 154 L + + K + +K +++M+ Y R K Sbjct: 70 ---------ILNHPNIVKLFEVIETEKT----LYLVMEYASGGEVFDYLVAHGRMKEKEA 116 Query: 155 LQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYK 214 +I+ ++Y H+ VH D+KA NLLL+ + + D+G + + Sbjct: 117 RAKFRQIVSAVQYCHQKYIVHRDLKAENLLLD--GDMNIKIADFGFSNEFT--------V 166 Query: 215 EDPKRCHDGTIEFTSIDAHNGVAP-SRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRD 273 + G+ + + + G D+ LG + ++G LP++ R Sbjct: 167 GNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERV 226 Query: 274 SKIRYRENIA 283 + +YR Sbjct: 227 LRGKYRIPFY 236 >2QNJ-A nrPDB Length = 328 Score = 158 bits (398), Expect = 6e-39, Method: Composition-based stats. Identities = 45/250 (18%), Positives = 90/250 (36%), Gaps = 31/250 (12%) Query: 36 EWKVGLPIGQGGFGCIYLAD-MNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPE 94 +++ IG+G F + LA + + V ++ P+ LF E++ + Sbjct: 13 NYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMK------ 66 Query: 95 QIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTV 154 L + + K + +K ++IM+ Y R K Sbjct: 67 ---------ILNHPNIVKLFEVIETEKT----LYLIMEYASGGEVFDYLVAHGRMKEKEA 113 Query: 155 LQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYK 214 +I+ ++Y H+ VH D+KA NLLL+ + + D+G + + G + Sbjct: 114 RSKFRQIVSAVQYCHQKRIVHRDLKAENLLLDAD--MNIKIADFGFSNEFTVGGKLDTF- 170 Query: 215 EDPKRCHDGTIEFTSIDAHNGVAP-SRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRD 273 G+ + + + G D+ LG + ++G LP++ R Sbjct: 171 -------CGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERV 223 Query: 274 SKIRYRENIA 283 + +YR Sbjct: 224 LRGKYRIPFY 233 >2HK5-A nrPDB Length = 270 Score = 157 bits (397), Expect = 6e-39, Method: Composition-based stats. Identities = 53/287 (18%), Positives = 115/287 (40%), Gaps = 45/287 (15%) Query: 38 KVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQ 97 K+ +G G FG +++A N V +K E + + ++ Sbjct: 18 KLEKKLGAGQFGEVWMATYNKHTKVAVK---TMKPGSMSVEAFLAEANVMKTLQHDKLVK 74 Query: 98 KWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF--GSDLQKIYEANAKRFSRKTVL 155 LH K ++I + GS L + + ++ Sbjct: 75 --------------------LHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLI 114 Query: 156 QLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKE 215 S +I + + +I + Y+H D++A+N+L++ + D+GLA ++ + Sbjct: 115 DFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVC--KIADFGLARVI------EDNEY 166 Query: 216 DPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT-GHLPWEDNLKDPKYVRDS 274 + I++T+ +A N + + + D+ G +++ +T G +P+ + +P+ +R Sbjct: 167 TAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPY-PGMSNPEVIRAL 225 Query: 275 KIRYR--------ENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTE 313 + YR E + ++M +C+ KN+P E + +LD E Sbjct: 226 ERGYRMPRPENCPEELYNIMMRCW--KNRPEERPTFEYIQSVLDDFE 270 >3H4J-B nrPDB Length = 336 Score = 157 bits (396), Expect = 8e-39, Method: Composition-based stats. Identities = 44/231 (19%), Positives = 91/231 (39%), Gaps = 31/231 (13%) Query: 37 WKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQI 96 + + +G+G FG + LA ++ +K F + +++ ++ Sbjct: 11 YIIRETLGEGSFGKVKLATHYKTQQ-----KVALK---------FISRQLLKKSDMHMRV 56 Query: 97 QKWIR-TRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVL 155 ++ I + L++ + K + + M+++ G +L Y KR + Sbjct: 57 EREISYLKLLRHPHIIKLYDV----ITTPTDIVMVIEYAGGELFD-YIVEKKRMTEDEGR 111 Query: 156 QLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKE 215 + +I+ +EY H H+ VH D+K NLLL+ + V + D+GL+ Sbjct: 112 RFFQQIICAIEYCHRHKIVHRDLKPENLLLD--DNLNVKIADFGLSNIMTDGNF------ 163 Query: 216 DPKRCHDGTIEFTSIDAHNGV-APSRRGDLEILGYCMIQWLTGHLPWEDNL 265 + G+ + + + NG D+ G + L G LP++D Sbjct: 164 --LKTSCGSPNYAAPEVINGKLYAGPEVDVWSCGIVLYVMLVGRLPFDDEF 212 >3MN3-A nrPDB Length = 271 Score = 157 bits (396), Expect = 8e-39, Method: Composition-based stats. Identities = 43/229 (18%), Positives = 86/229 (37%), Gaps = 29/229 (12%) Query: 36 EWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQ 95 +++ +G+G FG + LA ++ + KV + E Sbjct: 5 NYQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIE------------ 52 Query: 96 IQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVL 155 ++ R L++ + K + K M+++ G++L Y + S + Sbjct: 53 -REISYLRLLRHPHIIKLYDV----IKSKDEIIMVIEYAGNELFD-YIVQRDKMSEQEAR 106 Query: 156 QLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKE 215 + +I+ +EY H H+ VH D+K NLLL+ V + D+GL+ Sbjct: 107 RFFQQIISAVEYCHRHKIVHRDLKPENLLLDEHL--NVKIADFGLSNIMTDGNF------ 158 Query: 216 DPKRCHDGTIEFTSIDAHNGV-APSRRGDLEILGYCMIQWLTGHLPWED 263 + G+ + + + +G D+ G + L LP++D Sbjct: 159 --LKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYVMLCRRLPFDD 205 >3COM-A nrPDB Length = 314 Score = 157 bits (396), Expect = 9e-39, Method: Composition-based stats. Identities = 53/277 (19%), Positives = 99/277 (35%), Gaps = 47/277 (16%) Query: 37 WKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQI 96 + V +G+G +G +Y A + + + V+ SD + E+ Q+ P Sbjct: 31 FDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVE---SDLQEIIKEISIMQQCDSPH-- 85 Query: 97 QKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFG-SDLQKIYEANAKRFSRKTVL 155 V KY+GS + + +++M+ G + I K + + Sbjct: 86 -------------VVKYYGSYFKNTD----LWIVMEYCGAGSVSDIIRLRNKTLTEDEIA 128 Query: 156 QLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKE 215 + L LEY+H +H DIKA N+LLN + L D+G+A + Sbjct: 129 TILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEG--HAKLADFGVAGQLTDTM------- 179 Query: 216 DPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWED-----------N 264 + GT + + + + + D+ LG I+ G P+ D Sbjct: 180 AKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPT 239 Query: 265 LKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAK 301 P + + +N + +C + P + A Sbjct: 240 NPPPTFRKPELW--SDNFTDFVKQCLVKS--PEQRAT 272 >1U5R-A nrPDB Length = 348 Score = 157 bits (396), Expect = 1e-38, Method: Composition-based stats. Identities = 52/255 (20%), Positives = 89/255 (34%), Gaps = 37/255 (14%) Query: 11 RQSSAKRHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCV 69 L + D +K + IG G FG +Y A D+ +SE V Sbjct: 30 PAGGRAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSY 89 Query: 70 VKVEPSDN-GPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRF 128 + ++ + E++F Q+ P IQ Y G L + + Sbjct: 90 SGKQSNEKWQDIIKEVRFLQKLRHPNTIQ---------------YRGCYLREHTA----W 130 Query: 129 MIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYK 188 ++M+ + E + K + ++ L L Y+H H +H D+KA N+LL+ Sbjct: 131 LVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSE- 189 Query: 189 NPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSR---RGDLE 245 P V L D+G A P GT + + + + + + D+ Sbjct: 190 -PGLVKLGDFGSASIMAP-----------ANSFVGTPYWMAPEVILAMDEGQYDGKVDVW 237 Query: 246 ILGYCMIQWLTGHLP 260 LG I+ P Sbjct: 238 SLGITCIELAERKPP 252 >5FG8-A nrPDB Length = 285 Score = 156 bits (393), Expect = 2e-38, Method: Composition-based stats. Identities = 47/274 (17%), Positives = 89/274 (32%), Gaps = 34/274 (12%) Query: 33 AKKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAA 91 + + +G+G F + ++ + K+ D L E + ++ Sbjct: 12 FSDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLH 71 Query: 92 KPEQIQKWIRTRKLKYLGVPKYWGSGLHDK-NGKSYRFMIMDRF--GSDLQKIYEANAKR 148 P ++ LHD ++Y +++ D G + I Sbjct: 72 HPNIVR--------------------LHDSIQEENYHYLVFDLVTGGELFEDIVARE--F 109 Query: 149 FSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQ-VYLVDYGLAYRYCPE 207 +S +IL+ + + H++ VH D+K NLLL K V L D+GLA Sbjct: 110 YSEADASHCIQQILESVNHCHQNGVVHRDLKPENLLLASKAKGAAVKLADFGLA------ 163 Query: 208 GVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKD 267 + + GT + S + + D+ G + L G+ P+ D + Sbjct: 164 -IEVQGDHQAWFGFAGTPGYLSPEVLKKEPYGKSVDIWACGVILYILLVGYPPFWDEDQH 222 Query: 268 PKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAK 301 Y + Y KN ++ Sbjct: 223 RLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLT 256 >2V7O-A nrPDB Length = 336 Score = 155 bits (392), Expect = 2e-38, Method: Composition-based stats. Identities = 50/272 (18%), Positives = 98/272 (36%), Gaps = 34/272 (12%) Query: 35 KEWKVGLPIGQGGFGCIYLADMNS-SESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKP 93 ++++ +G+G F + + ++ + K+ D+ L E + Sbjct: 31 DDYQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSARDHQKLEREARIC------ 84 Query: 94 EQIQKWIRTRKLKYLGVPKYWGSGLHDK-NGKSYRFMIMDRF--GSDLQKIYEANAKRFS 150 R LK+ + + LHD + + + +++ D G + I +S Sbjct: 85 ---------RLLKHPNIVR-----LHDSISEEGFHYLVFDLVTGGELFEDIVARE--YYS 128 Query: 151 RKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQ-VYLVDYGLAYRYCPEGV 209 +IL+ + +IH+H+ VH D+K NLLL K V L D+GLA + Sbjct: 129 EADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLA-------I 181 Query: 210 HKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPK 269 + ++ GT + S + + D+ G + L G+ P+ D + Sbjct: 182 EVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKL 241 Query: 270 YVRDSKIRYRENIASLMDKCFPEKNKPGEIAK 301 Y + Y KN ++ Sbjct: 242 YQQIKAGAYDFPSPEWDTVTPEAKNLINQMLT 273 >3NCG-A nrPDB Length = 486 Score = 155 bits (392), Expect = 3e-38, Method: Composition-based stats. Identities = 43/275 (15%), Positives = 96/275 (34%), Gaps = 34/275 (12%) Query: 32 MAKKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRA 90 + + + +G+G FG + D + + + D + E++ ++ Sbjct: 19 TFAERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKL 78 Query: 91 AKPE--QIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKR 148 P ++ + + Y+ Y G L D+ K KR Sbjct: 79 DHPNIMKLFEILEDSSSFYIVGELYTGGELFDEIIKR---------------------KR 117 Query: 149 FSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNP-DQVYLVDYGLAYRYCPE 207 FS ++ ++ + Y+H+H VH D+K N+LL K + ++D+GL+ + Sbjct: 118 FSEHDAARIIKQVFSGITYMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQ-- 175 Query: 208 GVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKD 267 + + GT + + + G + D+ G + L+G P+ + Sbjct: 176 ------QNTKMKDRIGTAYYIAPEVLRGTY-DEKCDVWSAGVILYILLSGTPPFYGKNEY 228 Query: 268 PKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKY 302 R +Y ++ K+ ++ + Sbjct: 229 DILKRVETGKYAFDLPQWRTISDDAKDLIRKMLTF 263 >5IG1-A nrPDB Length = 344 Score = 155 bits (392), Expect = 3e-38, Method: Composition-based stats. Identities = 39/239 (16%), Positives = 76/239 (31%), Gaps = 29/239 (12%) Query: 43 IGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIR 101 IG+G F ++ + + E + + S+ + E+ + Sbjct: 25 IGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRSSEINKIKREIGICSSLQHEHIVSMRRA 84 Query: 102 TRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRI 161 R + +++ + K ++ K +I Sbjct: 85 FRDESH-------------------FYLVFEYVSGGELFDEIVTRKFYNEKDASACMHQI 125 Query: 162 LDILEYIHEHEYVHGDIKASNLLLNYKNPDQ-VYLVDYGLAYRYCPEGVHKEYKEDPKRC 220 L L++ H +H D+K NLLL K+P+ V + D+GLA + Sbjct: 126 LSALQHCHSKNIIHRDLKPENLLLASKDPNAPVKITDFGLAVIMEQGPTY--------FG 177 Query: 221 HDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRYR 279 GT + S + V D+ G + L G+ P+ + Y + +Y Sbjct: 178 FAGTPGYLSPEVIRRVPYDTAVDVWACGVILYILLVGYPPFWEEDHQKLYAQIKNCQYD 236 >2X4F-A nrPDB Length = 373 Score = 155 bits (392), Expect = 3e-38, Method: Composition-based stats. Identities = 39/245 (15%), Positives = 92/245 (37%), Gaps = 31/245 (12%) Query: 43 IGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRT 102 +G G FG ++ E + K+ + E+K + Sbjct: 97 LGGGRFGQVHKC-----EETATGLKLAAKIIKTRGMKDKEEVK-----------NEISVM 140 Query: 103 RKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYEANAKRFSRKTVLQLSLRI 161 +L + + + + + K+ ++M+ G +L + + + +I Sbjct: 141 NQLDHANLIQLYDA----FESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQI 196 Query: 162 LDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCH 221 + + ++H+ +H D+K N+L ++ Q+ ++D+GLA RY P + + + Sbjct: 197 CEGIRHMHQMYILHLDLKPENILCVNRDAKQIKIIDFGLARRYKP--------REKLKVN 248 Query: 222 DGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPW--EDNLKDPKYVRDSKIRYR 279 GT EF + + N S D+ +G L+G P+ +++ + + + Sbjct: 249 FGTPEFLAPEVVNYDFVSFPTDMWSVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLE 308 Query: 280 ENIAS 284 + Sbjct: 309 DEEFQ 313 >3DFA-A nrPDB Length = 286 Score = 155 bits (391), Expect = 3e-38, Method: Composition-based stats. Identities = 43/275 (15%), Positives = 96/275 (34%), Gaps = 34/275 (12%) Query: 32 MAKKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRA 90 + + + +G+G FG + D + + + D + E++ ++ Sbjct: 19 TFAERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKL 78 Query: 91 AKPE--QIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKR 148 P ++ + + Y+ Y G L D+ K KR Sbjct: 79 DHPNIMKLFEILEDSSSFYIVGELYTGGELFDEIIKR---------------------KR 117 Query: 149 FSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNP-DQVYLVDYGLAYRYCPE 207 FS ++ ++ + Y+H+H VH D+K N+LL K + ++D+GL+ + Sbjct: 118 FSEHDAARIIKQVFSGITYMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQ-- 175 Query: 208 GVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKD 267 + + GT + + + G + D+ G + L+G P+ + Sbjct: 176 ------QNTKMKDRIGTAYYIAPEVLRGTY-DEKCDVWSAGVILYILLSGTPPFYGKNEY 228 Query: 268 PKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKY 302 R +Y ++ K+ ++ + Sbjct: 229 DILKRVETGKYAFDLPQWRTISDDAKDLIRKMLTF 263 >4C0T-A nrPDB Length = 974 Score = 155 bits (390), Expect = 5e-38, Method: Composition-based stats. Identities = 46/245 (18%), Positives = 95/245 (38%), Gaps = 20/245 (8%) Query: 36 EWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQ 95 ++K G +G+G + + LA + VKV D + E K + Sbjct: 267 DFKFGKELGEGSYSTVILATDK-----ITGKQYAVKVL--DKRHIIKEKKVKYVNIEKHA 319 Query: 96 IQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVL 155 + + LGV + K + ++D + + + Sbjct: 320 LNRLS-----NRLGVISLY----FTFQDKDSLYFVLDYASNGELLTLIKRYNTLNEECTR 370 Query: 156 QLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRY-CPEGVHKEYK 214 +ILD ++Y+H++ +H D+K N+LL+ K ++ + D+G A +EY Sbjct: 371 HFGAQILDAIKYMHDNGVIHRDLKPENILLDDK--MRIQITDFGTARLLEKKNDESEEYP 428 Query: 215 ED-PKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRD 273 D + GT E+ S + + GD+ G + Q + G P++ + + + Sbjct: 429 VDVRAKSFVGTAEYVSPELLENKYCGKPGDVWAFGCIIYQMIAGKPPFKATNEYLTFQKI 488 Query: 274 SKIRY 278 +K+++ Sbjct: 489 TKLQF 493 >1FOT-A nrPDB Length = 318 Score = 155 bits (390), Expect = 5e-38, Method: Composition-based stats. Identities = 40/254 (15%), Positives = 90/254 (35%), Gaps = 29/254 (11%) Query: 30 TDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQR 89 + +++++ +G G FG ++L + +KV + ++ Sbjct: 1 PKYSLQDFQILRTLGTGSFGRVHLIRSR-----HNGRYYAMKVLKKEIVVRLKQV----- 50 Query: 90 AAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRF 149 + + + + + + WG+ FMIMD ++RF Sbjct: 51 ---EHTNDERLMLSIVTHPFIIRMWGT----FQDAQQIFMIMDYIEGGELFSLLRKSQRF 103 Query: 150 SRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGV 209 + + LEY+H + ++ D+K N+LL+ + + D+G A Y P+ Sbjct: 104 PNPVAKFYAAEVCLALEYLHSKDIIYRDLKPENILLDKNG--HIKITDFGFAK-YVPDVT 160 Query: 210 HKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPK 269 + GT ++ + + + ++ D G + + L G+ P+ D+ Sbjct: 161 Y---------TLCGTPDYIAPEVVSTKPYNKSIDWWSFGILIYEMLAGYTPFYDSNTMKT 211 Query: 270 YVRDSKIRYRENIA 283 Y + R Sbjct: 212 YEKILNAELRFPPF 225 >2WQN-A nrPDB Length = 310 Score = 154 bits (389), Expect = 5e-38, Method: Composition-based stats. Identities = 53/318 (16%), Positives = 114/318 (35%), Gaps = 37/318 (11%) Query: 10 GRQSSAKRHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCV 69 G Q Q A+ + +++ IG+G F +Y A + + Sbjct: 7 GMQGPPVPQFQPQKALRPDMGYNTLANFRIEKKIGRGQFSEVYRAAC----LLDGVPVAL 62 Query: 70 VKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFM 129 KV+ D A+ + I++ ++L + V KY+ S + D + Sbjct: 63 KKVQIFD---------LMDAKARADCIKEIDLLKQLNHPNVIKYYASFIEDNE----LNI 109 Query: 130 IMDRFG-SDLQKI---YEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLL 185 +++ DL ++ ++ + +TV + +++ LE++H +H DIK +N+ + Sbjct: 110 VLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHMHSRRVMHRDIKPANVFI 169 Query: 186 NYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLE 245 V L D GL + + GT + S + + + + D+ Sbjct: 170 TATG--VVKLGDLGLGRFFSSKTTAAH-------SLVGTPYYMSPERIHENGYNFKSDIW 220 Query: 246 ILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMET 305 LG + + P+ + + Y KI + P + E+ + + Sbjct: 221 SLGCLLYEMAALQSPFYGDKMN-LYSLCKKIEQCDYPP------LPSDHYSEELRQLVNM 273 Query: 306 VKLLDYTEKPLYENLRDI 323 D ++P + D+ Sbjct: 274 CINPDPEKRPDVTYVYDV 291 >2WTK-C nrPDB Length = 305 Score = 154 bits (389), Expect = 6e-38, Method: Composition-based stats. Identities = 49/249 (19%), Positives = 91/249 (36%), Gaps = 30/249 (12%) Query: 36 EWKVGLPIGQGGFGCIYLADMNSS---ESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAK 92 ++ +G +G+G +G + + + +V ++ P+ + E++ +R Sbjct: 6 KYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRH 65 Query: 93 PEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANA-KRFSR 151 IQ K +M+M+ +Q++ ++ KRF Sbjct: 66 KNVIQLVDVLYN-----------------EEKQKMYMVMEYCVCGMQEMLDSVPEKRFPV 108 Query: 152 KTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHK 211 +++D LEY+H VH DIK NLLL + + G+A E +H Sbjct: 109 CQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGT--LKISALGVA-----EALHP 161 Query: 212 EYKEDPKRCHDGTIEFTSIDAHNG--VAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPK 269 +D R G+ F + NG + D+ G + TG P+E + Sbjct: 162 FAADDTCRTSQGSPAFQPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKL 221 Query: 270 YVRDSKIRY 278 + K Y Sbjct: 222 FENIGKGSY 230 >2VN9-A nrPDB Length = 301 Score = 154 bits (389), Expect = 6e-38, Method: Composition-based stats. Identities = 47/250 (18%), Positives = 91/250 (36%), Gaps = 34/250 (13%) Query: 35 KEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKP 93 E+++ +G+G F + + + + + K+ D+ L E + Sbjct: 4 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARIC------ 57 Query: 94 EQIQKWIRTRKLKYLGVPKYWGSGLHDK-NGKSYRFMIMDRF--GSDLQKIYEANAKRFS 150 R LK+ + + LHD + + + +++ D G + I +S Sbjct: 58 ---------RLLKHPNIVR-----LHDSISEEGFHYLVFDLVTGGELFEDIVARE--YYS 101 Query: 151 RKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQ-VYLVDYGLAYRYCPEGV 209 +IL+ + + H + VH D+K NLLL K+ V L D+GLA + Sbjct: 102 EADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLA-------I 154 Query: 210 HKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPK 269 + + GT + S + + D+ G + L G+ P+ D + Sbjct: 155 EVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRL 214 Query: 270 YVRDSKIRYR 279 Y + Y Sbjct: 215 YQQIKAGAYD 224 >5D9K-A nrPDB Length = 330 Score = 154 bits (388), Expect = 8e-38, Method: Composition-based stats. Identities = 42/242 (17%), Positives = 87/242 (35%), Gaps = 24/242 (9%) Query: 36 EWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQ 95 ++++ +GQG FG ++L V K+ SD L+ + K Sbjct: 31 QFELLKVLGQGSFGKVFL---------------VKKISGSDARQLYAMKVLKKATLKVRD 75 Query: 96 IQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVL 155 + R + + + + ++I+D + F+ + V Sbjct: 76 RVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVK 135 Query: 156 QLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKE 215 + L+++H ++ D+K N+LL+ + + L D+GL+ E Sbjct: 136 FYLAELALALDHLHSLGIIYRDLKPENILLDEEG--HIKLTDFGLSKESIDH-------E 186 Query: 216 DPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSK 275 GT+E+ + + N ++ D G M + LTG LP++ + K Sbjct: 187 KKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILK 246 Query: 276 IR 277 + Sbjct: 247 AK 248 >2GCD-A nrPDB Length = 309 Score = 154 bits (388), Expect = 8e-38, Method: Composition-based stats. Identities = 51/235 (21%), Positives = 87/235 (37%), Gaps = 37/235 (15%) Query: 31 DMAKKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDN-GPLFTELKFYQ 88 D +K + IG G FG +Y A D+ +SE V + ++ + E++F Q Sbjct: 11 DDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQ 70 Query: 89 RAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKR 148 + P IQ Y G L + +++M+ + E + K Sbjct: 71 KLRHPNTIQ---------------YRGCYLREHTA----WLVMEYCLGSASDLLEVHKKP 111 Query: 149 FSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEG 208 + ++ L L Y+H H +H D+KA N+LL+ P V L D+G A P Sbjct: 112 LQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSE--PGLVKLGDFGSASIMAP-- 167 Query: 209 VHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSR---RGDLEILGYCMIQWLTGHLP 260 GT + + + + + + D+ LG I+ P Sbjct: 168 ---------ANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPP 213 >5KZ7-A nrPDB Length = 346 Score = 153 bits (387), Expect = 1e-37, Method: Composition-based stats. Identities = 43/250 (17%), Positives = 89/250 (35%), Gaps = 31/250 (12%) Query: 36 EWKVGLPIGQGGFGCIYLAD-MNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPE 94 +++ IG+G F + LA + + + V ++ S LF E++ + Sbjct: 34 NYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMK------ 87 Query: 95 QIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTV 154 L + + K + +K +++M+ Y R K Sbjct: 88 ---------VLNHPNIVKLFEVIETEKT----LYLVMEYASGGEVFDYLVAHGRMKEKEA 134 Query: 155 LQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYK 214 +I+ ++Y H+ VH D+KA NLLL+ + + D+G + + Sbjct: 135 RAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDAD--MNIKIADFGFSNEFT--------F 184 Query: 215 EDPKRCHDGTIEFTSIDAHNGVAP-SRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRD 273 + G+ + + + G D+ LG + ++G LP++ R Sbjct: 185 GNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERV 244 Query: 274 SKIRYRENIA 283 + +YR Sbjct: 245 LRGKYRIPFY 254 >4CZT-A nrPDB Length = 464 Score = 153 bits (385), Expect = 2e-37, Method: Composition-based stats. Identities = 44/260 (16%), Positives = 98/260 (37%), Gaps = 27/260 (10%) Query: 25 VGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTEL 84 G ++++G +G+G F + A +V + +KV + Sbjct: 1 PGIHSGRTRVGKYELGRTLGEGTFAKVKFA-----RNVENGDNVAIKVIDKE-------- 47 Query: 85 KFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYE 143 K + + ++ + +K+ V + + K+ + +++ G +L Sbjct: 48 KVLKNKMIAQIKREISTMKLIKHPNVIRMFEV----MASKTKIYFVLEFVTGGELFDKIS 103 Query: 144 ANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYR 203 +N R + ++++ ++Y H H D+K NLLL+ + + D+GL+ Sbjct: 104 SNG-RLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANG--ALKVSDFGLSAL 160 Query: 204 YCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAP-SRRGDLEILGYCMIQWLTGHLPWE 262 P+ V ++ GT + + + N + DL G + + G+LP+E Sbjct: 161 --PQQVRED---GLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFE 215 Query: 263 DNLKDPKYVRDSKIRYRENI 282 D+ Y + K + Sbjct: 216 DSNLTSLYKKIFKAEFTCPP 235 >4LG4-A nrPDB Length = 299 Score = 152 bits (384), Expect = 2e-37, Method: Composition-based stats. Identities = 56/307 (18%), Positives = 109/307 (35%), Gaps = 47/307 (15%) Query: 37 WKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQI 96 + V +G+G +G ++ A S V + V+ SD + E+ Q+ P Sbjct: 13 FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVE---SDLQEIIKEISIMQQCDSP--- 66 Query: 97 QKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFG-SDLQKIYEANAKRFSRKTVL 155 V KY+GS + + +++M+ G + I K + Sbjct: 67 ------------YVVKYYGSYFKNTD----LWIVMEYCGAGSVSDIIRLRNKTLIEDEIA 110 Query: 156 QLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKE 215 + L LEY+H +H +IKA N+LLN + L D+G+A + Sbjct: 111 TILKSTLKGLEYLHFMRKIHRNIKAGNILLNTEG--HAKLADFGVAGQLTDTM------- 161 Query: 216 DPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWED-----------N 264 + GT + + + + + D+ LG I+ G P+ D Sbjct: 162 AKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPT 221 Query: 265 LKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDIL 324 P + + ++ + KC + P + A + ++ LRD++ Sbjct: 222 NPPPTFRKPELW--SDDFTDFVKKCLVKN--PEQRATATQLLQHPFIKNAKPVSILRDLI 277 Query: 325 LQGLKAI 331 + ++ Sbjct: 278 TEAMEIK 284 >4RLP-A nrPDB Length = 288 Score = 152 bits (384), Expect = 2e-37, Method: Composition-based stats. Identities = 40/247 (16%), Positives = 82/247 (33%), Gaps = 22/247 (8%) Query: 37 WKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQI 96 +++ +G+GG+G ++ + + G +KV L + Sbjct: 7 FELLRVLGKGGYGKVFQVRKVTGANTG--KIFAMKV-------LKKAMIVRNAKDTAHTK 57 Query: 97 QKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQ 156 + ++K+ + + ++I++ + F T Sbjct: 58 AERNILEEVKHPFIVDLIYA----FQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACF 113 Query: 157 LSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKED 216 I L ++H+ ++ D+K N++LN + V L D+GL +G Sbjct: 114 YLAEISMALGHLHQKGIIYRDLKPENIMLN--HQGHVKLTDFGLCKESIHDGTVTH---- 167 Query: 217 PKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKI 276 GTIE+ + + +R D LG M LTG P+ + + K Sbjct: 168 ---TFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKC 224 Query: 277 RYRENIA 283 + Sbjct: 225 KLNLPPY 231 >3BHH-A nrPDB Length = 295 Score = 152 bits (383), Expect = 3e-37, Method: Composition-based stats. Identities = 51/272 (18%), Positives = 94/272 (34%), Gaps = 34/272 (12%) Query: 35 KEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKP 93 E+++ IG+G F + + + + K+ D+ L E + Sbjct: 4 DEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARIC------ 57 Query: 94 EQIQKWIRTRKLKYLGVPKYWGSGLHDK-NGKSYRFMIMDRF--GSDLQKIYEANAKRFS 150 R LK+ + + LHD + + + +++ D G + I +S Sbjct: 58 ---------RLLKHSNIVR-----LHDSISEEGFHYLVFDLVTGGELFEDIVARE--YYS 101 Query: 151 RKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQ-VYLVDYGLAYRYCPEGV 209 +IL+ + + H+ VH D+K NLLL K V L D+GLA + Sbjct: 102 EADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLA-------I 154 Query: 210 HKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPK 269 + + GT + S + A + D+ G + L G+ P+ D + Sbjct: 155 EVQGDQQAWFGFAGTPGYLSPEVLRKEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKL 214 Query: 270 YVRDSKIRYRENIASLMDKCFPEKNKPGEIAK 301 Y + Y KN ++ Sbjct: 215 YQQIKAGAYDFPSPEWDTVTPEAKNLINQMLT 246 >4QTB-A nrPDB Length = 380 Score = 152 bits (383), Expect = 3e-37, Method: Composition-based stats. Identities = 47/230 (20%), Positives = 93/230 (40%), Gaps = 23/230 (10%) Query: 33 AKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAK 92 + IG+G +G + ++ + V + K+ P F + QR + Sbjct: 39 VGPRYTQLQYIGEGAYGMV----SSAYDHVRKTRVAIKKISP------FEHQTYCQRTLR 88 Query: 93 PEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRK 152 +IQ +R R +G+ + + Y ++ D +DL K+ ++ S Sbjct: 89 --EIQILLRFRHENVIGIRDILRASTLEAMRDVY--IVQDLMETDLYKLLKSQQ--LSND 142 Query: 153 TVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKE 212 + +IL L+YIH +H D+K SNLL+N + + D+GLA PE H Sbjct: 143 HICYFLYQILRGLKYIHSANVLHRDLKPSNLLINT--TCDLKICDFGLARIADPEHDHTG 200 Query: 213 YKEDPKRCHDGTIEFTSID-AHNGVAPSRRGDLEILGYCMIQWLTGHLPW 261 + + + T + + + N ++ D+ +G + + L+ + Sbjct: 201 FLTE----YVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIF 246 >2Z7Q-A nrPDB Length = 321 Score = 152 bits (383), Expect = 3e-37, Method: Composition-based stats. Identities = 46/244 (18%), Positives = 94/244 (38%), Gaps = 28/244 (11%) Query: 36 EWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKP-- 93 +++ +GQG FG ++L V KV D+G L+ +K ++A Sbjct: 29 HFELLKVLGQGSFGKVFL---------------VRKVTRPDSGHLYA-MKVLKKATLKVR 72 Query: 94 EQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKT 153 ++++ + L + P + + + ++I+D + F+ + Sbjct: 73 DRVRTKMERDILADVNHP-FVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEED 131 Query: 154 VLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEY 213 V + L+++H ++ D+K N+LL+ + + L D+GL+ Sbjct: 132 VKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEG--HIKLTDFGLSKEAIDH------ 183 Query: 214 KEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRD 273 E GT+E+ + + N S D G M + LTG LP++ + Sbjct: 184 -EKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLI 242 Query: 274 SKIR 277 K + Sbjct: 243 LKAK 246 >5X3F-B nrPDB Length = 393 Score = 151 bits (382), Expect = 3e-37, Method: Composition-based stats. Identities = 58/356 (16%), Positives = 117/356 (32%), Gaps = 63/356 (17%) Query: 34 KKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKP 93 ++ +G G FG + L S + + + K + Sbjct: 83 LDQFDRIKTLGTGSFGRVMLVKHKESGN-------------HYAMKILDKQKVVKLKQIE 129 Query: 94 EQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKT 153 + + + + + + K S +M+M+ + RFS Sbjct: 130 HTLNEKRILQAVNFPFLVKL----EFSFKDNSNLYMVMEYVAGGEMFSHLRRIGRFSEPH 185 Query: 154 VLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEY 213 + +I+ EY+H + ++ D+K NLL++ + + + D+G A R Sbjct: 186 ARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY--IQVTDFGFAKRV--------- 234 Query: 214 KEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRD 273 + GT E+ + + ++ D LG + + G+ P+ + Y + Sbjct: 235 -KGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKI 293 Query: 274 SKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDILLQGL-KAIG 332 + R P + ++ + LR++L L K G Sbjct: 294 VSGKVR---------------FPSHFSSDLK-------------DLLRNLLQVDLTKRFG 325 Query: 333 SKDDGKLDLSVVENGGLKAKTITKKRKKE---IEESKEPGVEDTEWSNTQTEEAIQ 385 + +G D+ + +RK E I + K PG DT + EE I+ Sbjct: 326 NLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPG--DTSNFDDYEEEEIR 379 >6AO5-A nrPDB Length = 362 Score = 151 bits (382), Expect = 4e-37, Method: Composition-based stats. Identities = 65/363 (17%), Positives = 129/363 (35%), Gaps = 67/363 (18%) Query: 37 WKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQI 96 + V +G+G +G ++ A S V + V+ SD + E+ Q+ P Sbjct: 12 FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVE---SDLQEIIKEISIMQQCDSP--- 65 Query: 97 QKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFG-SDLQKIYEANAKRFSRKTVL 155 V KY+GS + + +++M+ G + I K + Sbjct: 66 ------------YVVKYYGSYFKNTD----LWIVMEYCGAGSVSDIIRLRNKTLIEDEIA 109 Query: 156 QLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKE 215 + L LEY+H +H +IKA N+LLN + L D+G+A + Sbjct: 110 TILKSTLKGLEYLHFMRKIHRNIKAGNILLNTEG--HAKLADFGVAGQLTDTM------- 160 Query: 216 DPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWED-----------N 264 + GT + + + + + D+ LG I+ G P+ D Sbjct: 161 AKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPT 220 Query: 265 LKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDIL 324 P + + ++ + KC + P + A + ++ LRD++ Sbjct: 221 NPPPTFRKPELW--SDDFTDFVKKCLVKN--PEQRATATQLLQHPFIKNAKPVSILRDLI 276 Query: 325 LQGLKAIGSK-----------------DDGKLDL--SV-VENGGLKAKTITKKRKKEIEE 364 + ++ + DG D ++ +E ++ K + ++EIEE Sbjct: 277 TEAMEIKAKRHEEQQRELEEEENWKVPQDGDFDFLKNLSLEELQMRLKALDPMMEREIEE 336 Query: 365 SKE 367 ++ Sbjct: 337 LRQ 339 >3ORZ-A nrPDB Length = 316 Score = 151 bits (382), Expect = 4e-37, Method: Composition-based stats. Identities = 56/287 (19%), Positives = 106/287 (36%), Gaps = 29/287 (10%) Query: 35 KEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPE 94 +++K G +G+G F + LA + + +K+ + + P Sbjct: 37 EDFKFGKILGEGSFSTVVLA-----RELATSREYAIKI--------LEKRHIIKENKVPY 83 Query: 95 QIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTV 154 ++ +L + K + + K Y + + G L+ I + + F Sbjct: 84 VTRERDVMSRLDHPFFVKLYFC--FQDDEKLYFGLSYAKNGELLKYIRKIGS--FDETCT 139 Query: 155 LQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYK 214 + I+ LEY+H +H D+K N+LLN + + D+G A PE K Sbjct: 140 RFYTAEIVSALEYLHGKGIIHRDLKPENILLNED--MHIQITDFGTAKVLSPES-----K 192 Query: 215 EDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDS 274 + GT ++ S + + + DL LG + Q + G P+ + + + Sbjct: 193 QARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKII 252 Query: 275 KIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLR 321 K+ Y +K FP+ E ++ K L E Y L+ Sbjct: 253 KLEYD-----FPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLK 294 >4L42-A nrPDB Length = 346 Score = 151 bits (382), Expect = 4e-37, Method: Composition-based stats. Identities = 40/247 (16%), Positives = 82/247 (33%), Gaps = 22/247 (8%) Query: 37 WKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQI 96 +++ +G+GG+G ++ + + G +KV L + Sbjct: 20 FELLRVLGKGGYGKVFQVRKVTGANTG--KIFAMKV-------LKKAMIVRNAKDTAHTK 70 Query: 97 QKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQ 156 + ++K+ + + ++I++ + F T Sbjct: 71 AERNILEEVKHPFIVDLIYA----FQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACF 126 Query: 157 LSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKED 216 I L ++H+ ++ D+K N++LN + V L D+GL +G Sbjct: 127 YLAEISMALGHLHQKGIIYRDLKPENIMLN--HQGHVKLTDFGLCKESIHDGTVTH---- 180 Query: 217 PKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKI 276 GTIE+ + + +R D LG M LTG P+ + + K Sbjct: 181 ---TFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKC 237 Query: 277 RYRENIA 283 + Sbjct: 238 KLNLPPY 244 >4D2V-A nrPDB Length = 356 Score = 151 bits (380), Expect = 6e-37, Method: Composition-based stats. Identities = 45/251 (17%), Positives = 95/251 (37%), Gaps = 30/251 (11%) Query: 31 DMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRA 90 D K +++ IG GGF + LA + + + SD + TE++ + Sbjct: 25 DELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALK-- 82 Query: 91 AKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFS 150 L++ + + + H + FM+++ Y + R S Sbjct: 83 -------------NLRHQHICQLY----HVLETANKIFMVLEYCPGGELFDYIISQDRLS 125 Query: 151 RKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGL-AYRYCPEGV 209 + + +I+ + Y+H Y H D+K NLL + ++ L+D+GL A + Sbjct: 126 EEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDE--YHKLKLIDFGLCAKPKGNKDY 183 Query: 210 HKEYKEDPKRCHDGTIEFTSIDAHNGVA-PSRRGDLEILGYCMIQWLTGHLPWEDNLKDP 268 H + G + + + + G + D+ +G + + G LP++D+ Sbjct: 184 HLQAC-------CGALAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDTAAA 236 Query: 269 KYVRDSKIRYR 279 + + +Y Sbjct: 237 LVAKIMRGKYD 247 >2J90-A nrPDB Length = 304 Score = 151 bits (380), Expect = 6e-37, Method: Composition-based stats. Identities = 47/252 (18%), Positives = 94/252 (37%), Gaps = 28/252 (11%) Query: 32 MAKKEWKVGLPIGQGGFGCIYLADMN-SSESVGSDAPCVVKVEPSDNGPLFTELKFYQRA 90 M + +++G +G G F + + + + ++ S G Sbjct: 23 MVEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRG-----------V 71 Query: 91 AKPEQIQKWIRTRKLKYLGVPKYWGSGLHD-KNGKSYRFMIMDRFGSDLQKIYEANAKRF 149 ++ E ++ R++++ + LHD K+ +I++ + A + Sbjct: 72 SREEIEREVNILREIRHPNIIT-----LHDIFENKTDVVLILELVSGGELFDFLAEKESL 126 Query: 150 SRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKN--PDQVYLVDYGLAYRYCPE 207 + Q +ILD + Y+H H D+K N++L KN ++ L+D+G+A Sbjct: 127 TEDEATQFLKQILDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIA------ 180 Query: 208 GVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKD 267 HK + + GT EF + + N D+ +G L+G P+ K Sbjct: 181 --HKIEAGNEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGETKQ 238 Query: 268 PKYVRDSKIRYR 279 S + Y Sbjct: 239 ETLTNISAVNYD 250 >5NGU-A nrPDB Length = 381 Score = 150 bits (379), Expect = 7e-37, Method: Composition-based stats. Identities = 47/253 (18%), Positives = 98/253 (38%), Gaps = 23/253 (9%) Query: 10 GRQSSAKRHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCV 69 G +A + + IG+G +G + ++ +++ + Sbjct: 17 GSHMAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMV----CSAYDNLNKVRVAI 72 Query: 70 VKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFM 129 K+ P F + QR + +I+ +R R +G+ + ++ Y + Sbjct: 73 KKISP------FEHQTYCQRTLR--EIKILLRFRHENIIGINDIIRAPTIEQMKDVY--I 122 Query: 130 IMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKN 189 + D +DL K+ + S + +IL L+YIH +H D+K SNLLLN Sbjct: 123 VQDLMETDLYKLLKTQ--HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNT-- 178 Query: 190 PDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSID-AHNGVAPSRRGDLEILG 248 + + D+GLA P+ H + + + T + + + N ++ D+ +G Sbjct: 179 TCDLKICDFGLARVADPDHDHTGFLTE----YVATRWYRAPEIMLNSKGYTKSIDIWSVG 234 Query: 249 YCMIQWLTGHLPW 261 + + L+ + Sbjct: 235 CILAEMLSNRPIF 247 >4CQG-A nrPDB Length = 331 Score = 150 bits (378), Expect = 1e-36, Method: Composition-based stats. Identities = 47/250 (18%), Positives = 99/250 (39%), Gaps = 28/250 (11%) Query: 31 DMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRA 90 D K +++ IG GGF + LA V + +K+ + + Sbjct: 5 DELLKYYELYETIGTGGFAKVKLAC-----HVLTGEMVAIKIMDKNALG----------S 49 Query: 91 AKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFS 150 P + + L++ + + + H K+ FM+++ Y + R S Sbjct: 50 DLPRVKTEIDALKSLRHQHICQLY----HVLETKNKIFMVLEYCPGGELFDYIISQDRLS 105 Query: 151 RKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVH 210 + + +IL + Y+H Y H D+K NLL + ++ L+D+GL P+G Sbjct: 106 EEETRVVFRQILSAVAYVHSQGYAHRDLKPENLLFDEN--HKLKLIDFGL--CAKPKGNK 161 Query: 211 KEYKEDPKRCHDGTIEFTSIDAHNGVA-PSRRGDLEILGYCMIQWLTGHLPWEDNLKDPK 269 + ++ G++ + + + G + D+ +G + + G LP++D+ Sbjct: 162 DYHLQEC----CGSLAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMAL 217 Query: 270 YVRDSKIRYR 279 Y + + +Y Sbjct: 218 YKKIMRGKYE 227 >5JZN-A nrPDB Length = 280 Score = 150 bits (378), Expect = 1e-36, Method: Composition-based stats. Identities = 45/255 (17%), Positives = 88/255 (34%), Gaps = 35/255 (13%) Query: 21 EQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPL 80 E G I + +KVG IG G F + S+ +K+ Sbjct: 5 EVSEEGFQIPATITERYKVGRTIGDGNFAVVKECVERST-----AREYALKIIKKSKCR- 58 Query: 81 FTELKFYQRAAKPEQIQKWIRT-RKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDL 138 K IQ + R++K+ + + + + + +++M+ G DL Sbjct: 59 ----------GKEHMIQNEVSILRRVKHPNIVLL----IEEMDVPTELYLVMELVKGGDL 104 Query: 139 QKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLL--NYKNPDQVYLV 196 + +++ + + + ++Y+H VH DIK NLL+ + + L Sbjct: 105 FDAITST-NKYTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLG 163 Query: 197 DYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT 256 D+GLA + P GT + + + + D+ G L Sbjct: 164 DFGLA----------TIVDGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLC 213 Query: 257 GHLPWEDNLKDPKYV 271 G P+ + D + + Sbjct: 214 GFPPFRGSGDDQEVL 228 >6FDY-U nrPDB Length = 276 Score = 150 bits (377), Expect = 1e-36, Method: Composition-based stats. Identities = 45/254 (17%), Positives = 81/254 (31%), Gaps = 33/254 (12%) Query: 34 KKEWKVGLPIGQGGFGCIYLADMN--SSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAA 91 + + +G G + +Y A + E V + + L TE++ + Sbjct: 10 LDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKGIR 69 Query: 92 KPEQIQKWIRTRKLKYLGVPKYWGSGLHDKN-GKSYRFMIMDRF-GSDLQKIYEANAKRF 149 P +Q L D ++IM+ G DL + + Sbjct: 70 HPHIVQ--------------------LKDFQWDSDNIYLIMEFCAGGDLSRFIHT-RRIL 108 Query: 150 SRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGV 209 K ++ L+++HE H D+K N+LL+ + L D+G A P Sbjct: 109 PEKVARVFMQQLASALQFLHERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSP--- 165 Query: 210 HKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPK 269 D K G+ + + + R DL +G + + L G P+ Sbjct: 166 -----WDEKHVLRGSPLYMAPEMVCQRQYDARVDLWSMGVILYEALFGQPPFASRSFSEL 220 Query: 270 YVRDSKIRYRENIA 283 + R E Sbjct: 221 EEKIRSNRVIELPL 234 >4RED-A nrPDB Length = 351 Score = 150 bits (377), Expect = 2e-36, Method: Composition-based stats. Identities = 45/250 (18%), Positives = 90/250 (36%), Gaps = 30/250 (12%) Query: 36 EWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQ 95 + +G +G G FG + + + VK+ + + + Sbjct: 15 HYILGDTLGVGTFGKV-----KVGKHELTGHAVAVKI---------LNRQKIRSLDVVGK 60 Query: 96 IQKWIRTRKL-KYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTV 154 I++ I+ KL ++ + K + + S FM+M+ Y R K Sbjct: 61 IRREIQNLKLFRHPHIIKLYQV----ISTPSDIFMVMEYVSGGELFDYICKNGRLDEKES 116 Query: 155 LQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYK 214 +L +IL ++Y H H VH D+K N+LL+ + D+GL+ + Sbjct: 117 RRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAH--MNAKIADFGLS--------NMMSD 166 Query: 215 EDPKRCHDGTIEFTSIDAHNGV-APSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRD 273 + R G+ + + + +G D+ G + L G LP++D+ + + Sbjct: 167 GEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKI 226 Query: 274 SKIRYRENIA 283 + Sbjct: 227 CDGIFYTPQY 236 >4YNZ-A nrPDB Length = 342 Score = 149 bits (376), Expect = 2e-36, Method: Composition-based stats. Identities = 42/246 (17%), Positives = 89/246 (36%), Gaps = 33/246 (13%) Query: 37 WKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQ 95 +++ +G+G G + L + + V K+ S + E+ + P Sbjct: 12 YRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHV 71 Query: 96 IQKWIRTRKLKYLGVPKYWGSGLHD-KNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTV 154 ++ LHD K Y +++++ Y R + K Sbjct: 72 LK--------------------LHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEA 111 Query: 155 LQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYK 214 + +I+ L++ H H H D+K NLLL+ +N + + D+G+A + + + Sbjct: 112 RKFFRQIISALDFCHSHSICHRDLKPENLLLDERN--NIRIADFGMASLQVGDSLLET-- 167 Query: 215 EDPKRCHDGTIEFTSIDAHNG-VAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRD 273 G+ + + G R+ D+ G + L G LP++D+ + Sbjct: 168 ------SCGSPHYACPEVIRGEKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKV 221 Query: 274 SKIRYR 279 + + Sbjct: 222 KRGVFH 227 >5WAX-A nrPDB Length = 310 Score = 149 bits (376), Expect = 2e-36, Method: Composition-based stats. Identities = 41/244 (16%), Positives = 79/244 (32%), Gaps = 33/244 (13%) Query: 32 MAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVK-VEPSDNGPLFTELKFYQRA 90 +++ IG G FG L VK +E + Sbjct: 8 HDGDRYELVRDIGSGNFGVARLMRNR-----ADGQLVAVKYIERGEK------------- 49 Query: 91 AKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFS 150 ++ I R L++ + ++ L ++ ++M+ NA RFS Sbjct: 50 IDENVQREIINHRSLRHPNIIRFKEVIL----TPTHLAIVMEYASGGELFERICNAGRFS 105 Query: 151 RKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVH 210 +++ + Y H + H D+K N LL+ ++ + D+G + Sbjct: 106 EDEARFFFQQLISGVSYCHSMQVCHRDLKLENTLLDGSTAPRLKICDFGYSK-------- 157 Query: 211 KEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRG-DLEILGYCMIQWLTGHLPWEDNLKDPK 269 + GT + + + + D+ G + L G P+ED +PK Sbjct: 158 SSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFED-PDEPK 216 Query: 270 YVRD 273 R Sbjct: 217 NFRK 220 >2VZ6-A nrPDB Length = 313 Score = 149 bits (375), Expect = 2e-36, Method: Composition-based stats. Identities = 44/247 (17%), Positives = 84/247 (34%), Gaps = 32/247 (12%) Query: 37 WKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQ 95 +++ +G+G F + + + + + K+ D+ L E + + P Sbjct: 24 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 83 Query: 96 IQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF--GSDLQKIYEANAKRFSRKT 153 ++ + + ++I D G + I +S Sbjct: 84 VRLHDSISEEGH-------------------HYLIFDLVTGGELFEDIVARE--YYSEAD 122 Query: 154 VLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQ-VYLVDYGLAYRYCPEGVHKE 212 +IL+ + + H+ VH D+K NLLL K V L D+GLA + E Sbjct: 123 ASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLA-------IEVE 175 Query: 213 YKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVR 272 ++ GT + S + + DL G + L G+ P+ D + Y + Sbjct: 176 GEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQ 235 Query: 273 DSKIRYR 279 Y Sbjct: 236 IKAGAYD 242 >4REW-A nrPDB Length = 540 Score = 149 bits (375), Expect = 2e-36, Method: Composition-based stats. Identities = 45/250 (18%), Positives = 90/250 (36%), Gaps = 30/250 (12%) Query: 36 EWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQ 95 + +G +G G FG + + + VK+ + + + Sbjct: 7 HYILGDTLGVGTFGKV-----KVGKHELTGHKVAVKI---------LNRQKIRSLDVVGK 52 Query: 96 IQKWIRTRKL-KYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTV 154 I++ I+ KL ++ + K + + S FM+M+ Y R K Sbjct: 53 IRREIQNLKLFRHPHIIKLYQV----ISTPSDIFMVMEYVSGGELFDYICKNGRLDEKES 108 Query: 155 LQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYK 214 +L +IL ++Y H H VH D+K N+LL+ + D+GL+ + Sbjct: 109 RRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAH--MNAKIADFGLS--------NMMSD 158 Query: 215 EDPKRCHDGTIEFTSIDAHNGV-APSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRD 273 + R G+ + + + +G D+ G + L G LP++D+ + + Sbjct: 159 GEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKI 218 Query: 274 SKIRYRENIA 283 + Sbjct: 219 CDGIFYTPQY 228 >4Y83-A nrPDB Length = 332 Score = 148 bits (374), Expect = 3e-36, Method: Composition-based stats. Identities = 58/260 (22%), Positives = 98/260 (37%), Gaps = 39/260 (15%) Query: 42 PIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWI 100 I +G FG +YLA D+ + + + V + +PSD +IQ Sbjct: 80 FIPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSDV-----------------EIQACF 122 Query: 101 RTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLR 160 R + L WG +H FM GS L+K+ R ++ ++ Sbjct: 123 RHENIAELYGAVLWGETVH-------LFMEAGEGGSVLEKLESCGPMR--EFEIIWVTKH 173 Query: 161 ILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRC 220 +L L+++H + +H DIK SN++ + LVD+GL+ + + + Sbjct: 174 VLKGLDFLHSKKVIHHDIKPSNIVFMST---KAVLVDFGLSVQMTEDV-------YFPKD 223 Query: 221 HDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKI--RY 278 GT + S + S + D+ LG +I TG PW Y I + Sbjct: 224 LRGTEIYMSPEVILCRGHSTKADIYSLGATLIHMQTGTPPWVKRYPRSAYPSYLYIIHKQ 283 Query: 279 RENIASLMDKCFPEKNKPGE 298 + + D C P + E Sbjct: 284 APPLEDIADDCSPGMRELIE 303 >5U6Y-A nrPDB Length = 461 Score = 148 bits (374), Expect = 3e-36, Method: Composition-based stats. Identities = 44/247 (17%), Positives = 84/247 (34%), Gaps = 32/247 (12%) Query: 37 WKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQ 95 +++ +G+G F + + + + + K+ D+ L E + + P Sbjct: 2 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 61 Query: 96 IQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF--GSDLQKIYEANAKRFSRKT 153 ++ + + ++I D G + I +S Sbjct: 62 VRLHDSISEEGH-------------------HYLIFDLVTGGELFEDIVARE--YYSEAD 100 Query: 154 VLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQ-VYLVDYGLAYRYCPEGVHKE 212 +IL+ + + H+ VH D+K NLLL K V L D+GLA + E Sbjct: 101 ASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLA-------IEVE 153 Query: 213 YKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVR 272 ++ GT + S + + DL G + L G+ P+ D + Y + Sbjct: 154 GEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQ 213 Query: 273 DSKIRYR 279 Y Sbjct: 214 IKAGAYD 220 >5N23-A nrPDB Length = 352 Score = 148 bits (374), Expect = 3e-36, Method: Composition-based stats. Identities = 57/356 (16%), Positives = 118/356 (33%), Gaps = 62/356 (17%) Query: 34 KKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKP 93 +++ +G G FG + L + + + + K + Sbjct: 41 LDQFERIRTLGTGSFGRVMLVKHKETGN-------------HYAMKILDKQKVVKLKQIE 87 Query: 94 EQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKT 153 + + + + + + K S +M+++ + RFS Sbjct: 88 HTLNEKRIQQAVNFPFLVKL----EFSFKDNSNLYMVLEYAPGGEMFSHLRRIGRFSEPH 143 Query: 154 VLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEY 213 + +I+ EY+H + ++ D+K NLL++ + + + D+G A R Sbjct: 144 ARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY--IKVADFGFAKR---------V 192 Query: 214 KEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRD 273 K GT E+ + + ++ D LG + + G+ P+ + Y + Sbjct: 193 KGRTPWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKI 252 Query: 274 SKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDILLQGL-KAIG 332 + R P + ++ + LR++L L K G Sbjct: 253 VSGKVR---------------FPSHFSSDLK-------------DLLRNLLQVDLTKRFG 284 Query: 333 SKDDGKLDLSVVENGGLKAKTITKKRKKE---IEESKEPGVEDTEWSNTQTEEAIQ 385 + +G D+ + +RK E I + K PG DT + EE I+ Sbjct: 285 NLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPG--DTSNFDDYEEEEIR 338 >4WNO-A nrPDB Length = 287 Score = 148 bits (374), Expect = 3e-36, Method: Composition-based stats. Identities = 46/299 (15%), Positives = 103/299 (34%), Gaps = 38/299 (12%) Query: 24 AVGEIITDMAKK-EWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFT 82 G T+ K E+ IG G F ++ ++ + C+ K + + L Sbjct: 6 EPGRGGTETVGKFEFSRKDLIGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQTLLG 65 Query: 83 ELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKI 141 ++ ++LK+ + + + + +++M+ G DL Sbjct: 66 --------------KEIKILKELKHENIVALYDF----QEMANSVYLVMEYCNGGDLADY 107 Query: 142 YEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLN-------YKNPDQVY 194 A + S T+ +I + +H +H D+K N+LL+ N +V Sbjct: 108 LHAM-RTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVK 166 Query: 195 LVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQW 254 + D+G A + G+ + + + + DL +G + Q Sbjct: 167 IADFGFARYLQSNMM--------AATLCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQC 218 Query: 255 LTGHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTE 313 LTG P++ + P+ +R + + + ++ + + +D+ E Sbjct: 219 LTGKAPFQAS--SPQDLRLFYEKNKTLVPTIPRETSAPLRQLLLALLQRNHKDRMDFDE 275 >6CCF-A nrPDB Length = 290 Score = 148 bits (374), Expect = 3e-36, Method: Composition-based stats. Identities = 57/280 (20%), Positives = 109/280 (38%), Gaps = 37/280 (13%) Query: 32 MAKKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVE--------PSDNGPLFT 82 M ++K+ IG+G +G + LA + + K+ P G Sbjct: 2 MQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAA 61 Query: 83 ELKFYQRAAKPEQIQKWIRT-RKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF--GSDLQ 139 + ++ E++ + I +KL ++ V K + D + +++ D G ++ Sbjct: 62 QGGPAKQLLPLERVYQEIAILKKLDHVNVVKLI--EVLDDPAEDNLYLVFDLLRKGPVME 119 Query: 140 KIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYG 199 K FS + ++ LEY+H + VH DIK SNLLL + V + D+G Sbjct: 120 ---VPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLG--DDGHVKIADFG 174 Query: 200 LAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRG---DLEILGYCMIQWLT 256 ++ ++ E + GT F + +A + S G D+ G + ++ Sbjct: 175 VSNQF-------EGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVY 227 Query: 257 GHLPWEDN--------LKDPKYVRDSKIRYRENIASLMDK 288 G P+ D+ +K+ V + E + L+ K Sbjct: 228 GKCPFIDDFILALHRKIKNEPVVFPEEPEISEELKDLILK 267 >1AD5-A nrPDB Length = 438 Score = 147 bits (371), Expect = 7e-36, Method: Composition-based stats. Identities = 52/297 (17%), Positives = 113/297 (38%), Gaps = 56/297 (18%) Query: 38 KVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQ 97 K+ +G G FG +++A N V +K E + + ++ Sbjct: 185 KLEKKLGAGQFGEVWMATYNKHTKVAVK---TMKPGSMSVEAFLAEANVMKTLQHDKLVK 241 Query: 98 KWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF--GSDLQKIYEANAKRFSRKTVL 155 LH K ++I + GS L + + ++ Sbjct: 242 --------------------LHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLI 281 Query: 156 QLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKE 215 S +I + + +I + Y+H D++A+N+L++ + D+GLA Sbjct: 282 DFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVC--KIADFGLARV------------ 327 Query: 216 DPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT-GHLPWEDNLKDPKYVRDS 274 I++T+ +A N + + + D+ G +++ +T G +P+ + +P+ +R Sbjct: 328 ----GAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPY-PGMSNPEVIRAL 382 Query: 275 KIRYR--------ENIASLMDKCFPEKNKPGEIAKYMETVKLL-DYTEKPLYENLRD 322 + YR E + ++M +C+ KN+P E + +L D+ + + Sbjct: 383 ERGYRMPRPENCPEELYNIMMRCW--KNRPEERPTFEYIQSVLDDFYTATESQYQQQ 437 >4NST-A nrPDB Length = 351 Score = 147 bits (371), Expect = 7e-36, Method: Composition-based stats. Identities = 49/243 (20%), Positives = 92/243 (37%), Gaps = 19/243 (7%) Query: 35 KEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKP 93 ++ + IG+G +G +Y A D ++ E V + + E+K ++ Sbjct: 13 DKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHR 72 Query: 94 EQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKT 153 + + L K K +++ + DL + E+ FS Sbjct: 73 SVVNMKE---------IVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDH 123 Query: 154 VLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEY 213 + ++++ LEY H+ ++H DIK SN+LLN Q+ L D+GLA Y E Sbjct: 124 IKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSG--QIKLADFGLARLYNSEES---- 177 Query: 214 KEDPKRCHDGTIEFTSIDAHNGVAPSRRG-DLEILGYCMIQWLTGHLPWEDNLKDPKYVR 272 P T+ + + G D+ G + + T ++ NL+ + Sbjct: 178 --RPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLEL 235 Query: 273 DSK 275 S+ Sbjct: 236 ISR 238 >3SOA-A nrPDB Length = 444 Score = 147 bits (371), Expect = 8e-36, Method: Composition-based stats. Identities = 45/259 (17%), Positives = 88/259 (33%), Gaps = 32/259 (12%) Query: 25 VGEIITDMAKKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTE 83 + I +E+++ +G+G F + + + + + K+ D+ L E Sbjct: 1 MATITCTRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDHQKLERE 60 Query: 84 LKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF--GSDLQKI 141 + + P ++ + + ++I D G + I Sbjct: 61 ARICRLLKHPNIVRLHDSISEEGH-------------------HYLIFDLVTGGELFEDI 101 Query: 142 YEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQ-VYLVDYGL 200 +S +IL+ + + H+ VH ++K NLLL K V L D+GL Sbjct: 102 VARE--YYSEADASHCIQQILEAVLHCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGL 159 Query: 201 AYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLP 260 A + E ++ GT + S + + DL G + L G+ P Sbjct: 160 A-------IEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPP 212 Query: 261 WEDNLKDPKYVRDSKIRYR 279 + D + Y + Y Sbjct: 213 FWDEDQHRLYQQIKAGAYD 231 >4QMW-A nrPDB Length = 310 Score = 147 bits (370), Expect = 8e-36, Method: Composition-based stats. Identities = 46/224 (20%), Positives = 85/224 (37%), Gaps = 29/224 (12%) Query: 37 WKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQI 96 + IG+G FG ++ N ++ V + ++ + + E+ + P Sbjct: 31 FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSP--- 87 Query: 97 QKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQ 156 V KY+GS L D ++IM+ G + + Sbjct: 88 ------------YVTKYYGSYLKDTK----LWIIMEYLGGG-SALDLLEPGPLDETQIAT 130 Query: 157 LSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKED 216 + IL L+Y+H + +H DIKA+N+LL+ +V L D+G+A + + Sbjct: 131 ILREILKGLDYLHSEKKIHRDIKAANVLLSEHG--EVKLADFGVAGQLTDTQI------- 181 Query: 217 PKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLP 260 + GT + + + A + D+ LG I+ G P Sbjct: 182 KRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPP 225 >1V0B-A nrPDB Length = 288 Score = 147 bits (370), Expect = 1e-35, Method: Composition-based stats. Identities = 44/244 (18%), Positives = 96/244 (39%), Gaps = 29/244 (11%) Query: 34 KKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKP 93 +++ IG+G +G +Y A N E+ +++E D G Sbjct: 1 MEKYHGLEKIGEGTYGVVYKAQNNYGETFALKK---IRLEKEDEG------------IPS 45 Query: 94 EQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKT 153 I++ ++LK+ + K + + K ++ + DL+K+ + T Sbjct: 46 TTIREISILKELKHSNIVKLYDV----IHTKKRLVLVFEHLDQDLKKLLDVCEGGLESVT 101 Query: 154 VLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEY 213 L++L+ + Y H+ +H D+K NLL+N + ++ + D+GLA + Sbjct: 102 AKSFLLQLLNGIAYCHDRRVLHRDLKPQNLLINREG--ELKIADFGLARAFG-----IPV 154 Query: 214 KEDPKRCHDGTIEFTSIDAHNG-VAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVR 272 ++ T+ + + D G S D+ +G + + G + + + +R Sbjct: 155 RKYTHEVV--TLWYRAPDVLMGSKKYSTTIDIWSVGCIFAEMVNGAPLFPGVSEADQLMR 212 Query: 273 DSKI 276 +I Sbjct: 213 IFRI 216 >4CFH-A nrPDB Length = 493 Score = 146 bits (369), Expect = 1e-35, Method: Composition-based stats. Identities = 54/317 (17%), Positives = 108/317 (34%), Gaps = 39/317 (12%) Query: 36 EWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQ 95 + +G +G G FG + + + VK+ + + + Sbjct: 34 HYILGDTLGVGTFGKV-----KVGKHELTGHKVAVKI---------LNRQKIRSLDVVGK 79 Query: 96 IQKWIRTRKL-KYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTV 154 I++ I+ KL ++ + K + + S FM+M+ Y R K Sbjct: 80 IRREIQNLKLFRHPHIIKLYQV----ISTPSDIFMVMEYVSGGELFDYICKNGRLDEKES 135 Query: 155 LQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYK 214 +L +IL ++Y H H VH D+K N+LL+ + D+GL+ + Sbjct: 136 RRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAH--MNAKIADFGLS--------NMMSD 185 Query: 215 EDPKRCHDGTIEFTSIDAHNGV-APSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRD 273 + R G+ + + + +G D+ G + L G LP++D+ + + Sbjct: 186 GEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKI 245 Query: 274 SKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDILLQGLKAIGS 333 + K+ T+K + E Q L Sbjct: 246 CDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHE---------WFKQDLPKYLF 296 Query: 334 KDDGKLDLSVVENGGLK 350 +D +++++ LK Sbjct: 297 PEDPSYSSTMIDDEALK 313 >5EFQ-A nrPDB Length = 347 Score = 146 bits (369), Expect = 1e-35, Method: Composition-based stats. Identities = 49/244 (20%), Positives = 96/244 (39%), Gaps = 19/244 (7%) Query: 35 KEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKP 93 ++ + IG+G +G +Y A D ++ E V + + E+K ++ Sbjct: 11 DKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTH- 69 Query: 94 EQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKT 153 Q I ++ + L K K +++ + DL + E+ F+ Sbjct: 70 ---QSIINMKE-----IVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENH 121 Query: 154 VLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEY 213 + ++++ L+Y H+ ++H DIK SN+LLN + Q+ L D+GLA Y E Sbjct: 122 IKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRG--QIKLADFGLARLYSSEES---- 175 Query: 214 KEDPKRCHDGTIEFTSIDAHNGVAPSRRG-DLEILGYCMIQWLTGHLPWEDNLKDPKYVR 272 P T+ + + G D+ G + + T ++ N + + Sbjct: 176 --RPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLEL 233 Query: 273 DSKI 276 S+I Sbjct: 234 ISRI 237 >4IDT-A nrPDB Length = 356 Score = 146 bits (368), Expect = 2e-35, Method: Composition-based stats. Identities = 41/233 (17%), Positives = 78/233 (33%), Gaps = 28/233 (12%) Query: 42 PIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIR 101 +G+G FG ++ + + C VK + ++ + Sbjct: 81 RLGRGSFGEVHRMEDKQT-----GFQCAVKKVRLEVFR----------------AEELMA 119 Query: 102 TRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRI 161 L + +G+ + + M+ L + Sbjct: 120 CAGLTSPRIVPLYGA----VREGPWVNIFMELLEGGSLGQLVKEQGCLPEDRALYYLGQA 175 Query: 162 LDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCH 221 L+ LEY+H +HGD+KA N+LL+ L D+G A P+G+ K+ Sbjct: 176 LEGLEYLHSRRILHGDVKADNVLLSSDGSHAA-LCDFGHAVCLQPDGLGKDLLTGDYIP- 233 Query: 222 DGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDS 274 GT + + G + + D+ M+ L G PW + P ++ + Sbjct: 234 -GTETHMAPEVVLGRSCDAKVDVWSSCCMMLHMLNGCHPWTQFFRGPLCLKIA 285 >4CFF-A nrPDB Length = 571 Score = 146 bits (367), Expect = 2e-35, Method: Composition-based stats. Identities = 50/318 (15%), Positives = 111/318 (34%), Gaps = 41/318 (12%) Query: 36 EWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQ 95 + +G +G G FG + E + VK+ + +R Sbjct: 34 HYVLGDTLGVGTFGKV-----KIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKR------ 82 Query: 96 IQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVL 155 + + ++ + K + + + FM+M+ Y R Sbjct: 83 --EIQNLKLFRHPHIIKLYQV----ISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEAR 136 Query: 156 QLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKE 215 +L +IL ++Y H H VH D+K N+LL+ + D+GL+ + Sbjct: 137 RLFQQILSAVDYCHRHMVVHRDLKPENVLLDAH--MNAKIADFGLS--------NMMSDG 186 Query: 216 DPKRCHDGTIEFTSIDAHNGV-APSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDS 274 + R G+ + + + +G D+ G + L G LP++D + + Sbjct: 187 EFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIR 246 Query: 275 KIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLR--DILLQGLKAIG 332 + + + +A + + +D ++ +++R + Q L + Sbjct: 247 GGVF-----------YIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYL 295 Query: 333 SKDDGKLDLSVVENGGLK 350 +D D +V+++ +K Sbjct: 296 FPEDPSYDANVIDDEAVK 313 >4G3E-A nrPDB Length = 352 Score = 146 bits (367), Expect = 2e-35, Method: Composition-based stats. Identities = 45/241 (18%), Positives = 85/241 (35%), Gaps = 31/241 (12%) Query: 36 EWKVGLP-IGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPE 94 W P +G+G FG ++ + C VK + Sbjct: 74 HWMTHQPRVGRGSFGEVHRMKDKQT-----GFQCAVKKVRLEVFR--------------- 113 Query: 95 QIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYEANAKRFSRKT 153 +++ + L + +G+ + + M+ G L ++ + Sbjct: 114 -VEELVACAGLSSPRIVPLYGA----VREGPWVNIFMELLEGGSLGQLIKQMG-CLPEDR 167 Query: 154 VLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEY 213 L + L+ LEY+H +HGD+KA N+LL+ + + L D+G A P+G+ K Sbjct: 168 ALYYLGQALEGLEYLHTRRILHGDVKADNVLLSS-DGSRAALCDFGHALCLQPDGLGKSL 226 Query: 214 KEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRD 273 GT + + G + D+ M+ L G PW + P ++ Sbjct: 227 LTGDYIP--GTETHMAPEVVMGKPCDAKVDIWSSCCMMLHMLNGCHPWTQYFRGPLCLKI 284 Query: 274 S 274 + Sbjct: 285 A 285 >3HDN-A nrPDB Length = 373 Score = 145 bits (366), Expect = 2e-35, Method: Composition-based stats. Identities = 41/253 (16%), Positives = 82/253 (32%), Gaps = 28/253 (11%) Query: 20 AEQFAVGEIITDMAKK-EWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNG 78 ++Q +G AK ++ IG+G FG + LA + E + K Sbjct: 22 SQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKK------- 74 Query: 79 PLFTELKFYQRAAKPEQI-QKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSD 137 ++ + + ++ + + +K+ + + ++D Sbjct: 75 ------AILKKKEEKHIMSERNVLLKNVKHP----FLVGLHFSFQTADKLYFVLDYINGG 124 Query: 138 LQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVD 197 + + F + I L Y+H V+ D+K N+LL+ + + L D Sbjct: 125 ELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQG--HIVLTD 182 Query: 198 YGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTG 257 +GL GT E+ + + + R D LG + + L G Sbjct: 183 FGLCKENIEH-------NSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYG 235 Query: 258 HLPWEDNLKDPKY 270 P+ Y Sbjct: 236 LPPFYSRNTAEMY 248 >4CSV-A nrPDB Length = 275 Score = 145 bits (365), Expect = 3e-35, Method: Composition-based stats. Identities = 51/281 (18%), Positives = 106/281 (37%), Gaps = 39/281 (13%) Query: 39 VGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQK 98 + +G G FG +Y + + VK + E +Q+ Sbjct: 15 LERKLGSGQFGEVYEGKWRNY-----NIEVAVKTLKEGT------------MSVEEFLQE 57 Query: 99 WIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLS 158 +KLK+ + + +G + K Y GS L + + + + +L ++ Sbjct: 58 AQIMKKLKHPNLVQLYG--VCTKEPPIYIITEYMSHGSLLDYLRDCEGHTVNAQALLDMA 115 Query: 159 LRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPK 218 ++ + Y+ ++H D+ A N L+ N V + D+GLA + + Sbjct: 116 AQVASGMAYLESQNFIHRDLAARNCLVGENN--VVKVADFGLARLINEDE------YTAR 167 Query: 219 RCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQ-WLTGHLPWEDNLKDPKYVRDSKIR 277 I++T+ +A + S + D+ G + + + G +P+ + + + + Sbjct: 168 AGAKFPIKWTAPEAISYNRFSIKSDVWAFGILLWEIFTYGQVPY-PGMSGSEVIEQVERG 226 Query: 278 YR--------ENIASLMDKCFPEKNKPGEIAKYMETVKLLD 310 YR E I LM +C+ + P E + ET+ L+ Sbjct: 227 YRMPRPQGCPEEIYELMLQCWNKS--PEERPTFAETLHALE 265 >5EZV-A nrPDB Length = 560 Score = 145 bits (364), Expect = 5e-35, Method: Composition-based stats. Identities = 50/318 (15%), Positives = 111/318 (34%), Gaps = 41/318 (12%) Query: 36 EWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQ 95 + +G +G G FG + E + VK+ + +R Sbjct: 29 HYVLGDTLGVGTFGKV-----KIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKR------ 77 Query: 96 IQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVL 155 + + ++ + K + + + FM+M+ Y R Sbjct: 78 --EIQNLKLFRHPHIIKLYQV----ISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEAR 131 Query: 156 QLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKE 215 +L +IL ++Y H H VH D+K N+LL+ + D+GL+ + Sbjct: 132 RLFQQILSAVDYCHRHMVVHRDLKPENVLLDAH--MNAKIADFGLS--------NMMSDG 181 Query: 216 DPKRCHDGTIEFTSIDAHNGV-APSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDS 274 + R G+ + + + +G D+ G + L G LP++D + + Sbjct: 182 EFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIR 241 Query: 275 KIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLR--DILLQGLKAIG 332 + + + +A + + +D ++ +++R + Q L + Sbjct: 242 GGVF-----------YIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYL 290 Query: 333 SKDDGKLDLSVVENGGLK 350 +D D +V+++ +K Sbjct: 291 FPEDPSYDANVIDDEAVK 308 >2JDO-A nrPDB Length = 342 Score = 145 bits (364), Expect = 5e-35, Method: Composition-based stats. Identities = 42/262 (16%), Positives = 95/262 (36%), Gaps = 30/262 (11%) Query: 26 GEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELK 85 G + + ++ +G+G FG + L + +K+ + E+ Sbjct: 1 GAMDPKVTMNDFDYLKLLGKGTFGKVILVREK-----ATGRYYAMKILRKEVIIAKDEVA 55 Query: 86 FYQRAAKPEQIQKWIRTRKLKYLGVPKY-WGSGLHDKNGKSYRFMIMDRFGSDLQKIYEA 144 + + + ++ + + HD+ +M+ + + Sbjct: 56 --------HTVTESRVLQNTRHPFLTALKYAFQTHDRLCF-----VMEYANGGELFFHLS 102 Query: 145 NAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRY 204 + F+ + I+ LEY+H + V+ DIK NL+L+ + + D+GL Sbjct: 103 RERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDG--HIKITDFGLCKEG 160 Query: 205 CPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPW--E 262 +G + GT E+ + + R D LG M + + G LP+ + Sbjct: 161 ISDG-------ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQ 213 Query: 263 DNLKDPKYVRDSKIRYRENIAS 284 D+ + + + +IR+ ++ Sbjct: 214 DHERLFELILMEEIRFPRTLSP 235 >3UC3-A nrPDB Length = 361 Score = 145 bits (364), Expect = 5e-35, Method: Composition-based stats. Identities = 39/246 (15%), Positives = 77/246 (31%), Gaps = 30/246 (12%) Query: 32 MAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAA 91 + IG G FG L ++ + + A Sbjct: 17 HDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERG-----------------AAI 59 Query: 92 KPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSR 151 ++ I R L++ + ++ L ++ +IM+ NA RFS Sbjct: 60 DENVQREIINHRSLRHPNIVRFKEVIL----TPTHLAIIMEYASGGELYERICNAGRFSE 115 Query: 152 KTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHK 211 ++L + Y H + H D+K N LL+ ++ + D+G + Sbjct: 116 DEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSK--------S 167 Query: 212 EYKEDPKRCHDGTIEFTSIDAHNGVAPSRR-GDLEILGYCMIQWLTGHLPWEDNLKDPKY 270 + GT + + + + D+ G + L G P+ED + Y Sbjct: 168 SVLHSQPKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDY 227 Query: 271 VRDSKI 276 + + Sbjct: 228 RKTIQR 233 >3KN6-A nrPDB Length = 325 Score = 144 bits (363), Expect = 5e-35, Method: Composition-based stats. Identities = 42/260 (16%), Positives = 91/260 (35%), Gaps = 32/260 (12%) Query: 41 LPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWI 100 P+G+G F S + ++E + E+ + Sbjct: 17 KPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQ----KEITALKLC---------- 62 Query: 101 RTRKLKYLGVPKYWGSGLHD-KNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSL 159 + + K LH+ + + + F++M+ K FS + Sbjct: 63 ----EGHPNIVK-----LHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMR 113 Query: 160 RILDILEYIHEHEYVHGDIKASNLLLNYKNPD-QVYLVDYGLAYRYCPEGVHKEYKEDPK 218 +++ + ++H+ VH D+K NLL +N + ++ ++D+G A P+ P Sbjct: 114 KLVSAVSHMHDVGVVHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQ-------PL 166 Query: 219 RCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRY 278 + T+ + + + N DL LG + L+G +P++ + + +I Sbjct: 167 KTPCFTLHYAAPELLNQNGYDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMK 226 Query: 279 RENIASLMDKCFPEKNKPGE 298 + + KN E Sbjct: 227 KIKKGDFSFEGEAWKNVSQE 246 >2XIK-A nrPDB Length = 294 Score = 144 bits (363), Expect = 6e-35, Method: Composition-based stats. Identities = 44/219 (20%), Positives = 83/219 (37%), Gaps = 29/219 (13%) Query: 42 PIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIR 101 IG+G FG +Y N ++ V + ++ + + E+ + P Sbjct: 26 RIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSP-------- 77 Query: 102 TRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRI 161 + +Y+GS L + ++IM+ G + + + I Sbjct: 78 -------YITRYFGSYLK----STKLWIIMEYLGGG-SALDLLKPGPLEETYIATILREI 125 Query: 162 LDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCH 221 L L+Y+H +H DIKA+N+LL+ + V L D+G+A + + + Sbjct: 126 LKGLDYLHSERKIHRDIKAANVLLSEQG--DVKLADFGVAGQLTDTQI-------KRNTF 176 Query: 222 DGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLP 260 GT + + + A + D+ LG I+ G P Sbjct: 177 VGTPFWMAPEVIKQSAYDFKADIWSLGITAIELAKGEPP 215 >2YZA-A nrPDB Length = 276 Score = 144 bits (363), Expect = 6e-35, Method: Composition-based stats. Identities = 41/239 (17%), Positives = 80/239 (33%), Gaps = 28/239 (11%) Query: 36 EWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQ 95 + +G +G G FG + E + VK+ + +R Sbjct: 12 HYVLGDTLGVGTFGKV-----KIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKR------ 60 Query: 96 IQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVL 155 + + ++ + K + + + FM+M+ Y R Sbjct: 61 --EIQNLKLFRHPHIIKLYQV----ISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEAR 114 Query: 156 QLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKE 215 +L +IL ++Y H H VH D+K N+LL+ + D+GL+ Sbjct: 115 RLFQQILSAVDYCHRHMVVHRDLKPENVLLDAH--MNAKIADFGLSNMMSDGEF------ 166 Query: 216 DPKRCHDGTIEFTSIDAHNGV-APSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRD 273 R G+ + + + +G D+ G + L G LP++D + + Sbjct: 167 --LRDSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKI 223 >4WB7-A nrPDB Length = 405 Score = 144 bits (362), Expect = 8e-35, Method: Composition-based stats. Identities = 57/356 (16%), Positives = 118/356 (33%), Gaps = 63/356 (17%) Query: 34 KKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKP 93 +++ +G G FG + L + + + + K + Sbjct: 95 LDQFERIKTLGTGSFGRVMLVKHKETGN-------------HYAMKILDKQKVVKLKQIE 141 Query: 94 EQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKT 153 + + + + + + K S +M+M+ + RFS Sbjct: 142 HTLNEKRILQAVNFPFLVKL----EFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPH 197 Query: 154 VLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEY 213 + +I+ EY+H + ++ D+K NLL++ + + + D+G A R Sbjct: 198 ARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY--IQVTDFGFAKRV--------- 246 Query: 214 KEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRD 273 + GT E+ + + ++ D LG + + G+ P+ + Y + Sbjct: 247 -KGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKI 305 Query: 274 SKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDILLQGL-KAIG 332 + R P + ++ + LR++L L K G Sbjct: 306 VSGKVR---------------FPSHFSSDLK-------------DLLRNLLQVDLTKRFG 337 Query: 333 SKDDGKLDLSVVENGGLKAKTITKKRKKE---IEESKEPGVEDTEWSNTQTEEAIQ 385 + +G D+ + +RK E I + K PG DT + EE I+ Sbjct: 338 NLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPG--DTSNFDDYEEEEIR 391 >6CMJ-A nrPDB Length = 321 Score = 143 bits (361), Expect = 1e-34, Method: Composition-based stats. Identities = 41/238 (17%), Positives = 88/238 (36%), Gaps = 26/238 (10%) Query: 32 MAKKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRA 90 + ++ + IG+G +G + LA + N + K+ G + R Sbjct: 31 VQLDQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGGCIQP------RG 84 Query: 91 AKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF--GSDLQKIYEANAKR 148 + Q+ +KL + V K + D + + +M+ + G ++ K Sbjct: 85 PIEQVYQEIAILKKLDHPNVVKLV--EVLDDPNEDHLYMVFELVNQGPVME---VPTLKP 139 Query: 149 FSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEG 208 S ++ +EY+H + +H DIK SNLL+ + + D+G++ + Sbjct: 140 LSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDG--HIKIADFGVSNEFKGSD 197 Query: 209 VHKEYKEDPKRCHDGTIEFTSIDAH---NGVAPSRRGDLEILGYCMIQWLTGHLPWED 263 GT F + ++ + + D+ +G + ++ G P+ D Sbjct: 198 -------ALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMD 248 >4D28-A nrPDB Length = 446 Score = 143 bits (361), Expect = 1e-34, Method: Composition-based stats. Identities = 41/251 (16%), Positives = 95/251 (37%), Gaps = 33/251 (13%) Query: 36 EWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPE 94 +++VG IG+G F + A + ++ ++V + + + Sbjct: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKN---------------RMVD 54 Query: 95 QIQKWIRT-RKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYEANAKRFSRK 152 QI++ I + +++ + + + KS +++++ G +L + R Sbjct: 55 QIKREISIMKIVRHPNIVRLYEVL----ASKSKIYIVLEFVTGGELFDRI-VHKGRLKED 109 Query: 153 TVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKE 212 + +++D + + H H D+K NLLL+ + + D+GL+ EGV Sbjct: 110 ESRKYFQQLVDAVAHCHSKGVYHRDLKPENLLLDTNG--NLKVSDFGLS-ALPQEGV--- 163 Query: 213 YKEDPKRCHDGTIEFTSIDAHNGVAP-SRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYV 271 + GT + + + +G D+ G + L G+LP+ + Y Sbjct: 164 ---ELLNDTCGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYR 220 Query: 272 RDSKIRYRENI 282 + + + Sbjct: 221 KINAAEFDCPP 231 >4RA4-A nrPDB Length = 355 Score = 143 bits (361), Expect = 1e-34, Method: Composition-based stats. Identities = 41/312 (13%), Positives = 104/312 (33%), Gaps = 37/312 (11%) Query: 21 EQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPL 80 ++ + + ++ + +G+G FG + LAD +E + +K+ D Sbjct: 6 DRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELY-----AIKILKKDVVIQ 60 Query: 81 FTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQK 140 +++ + R L L P + + +M+ Sbjct: 61 DDDVEC-----------TMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLM 109 Query: 141 IYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGL 200 + +F + + I L ++H+ ++ D+K N++L+ + + + D+G+ Sbjct: 110 YHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEG--HIKIADFGM 167 Query: 201 AYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLP 260 + +GV R GT ++ + + + D G + + L G P Sbjct: 168 CKEHMMDGV-------TTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPP 220 Query: 261 WEDNLKDPKYVRDSK------IRYRENIASLMDKCFPEKNKPGEI----AKYMETVKLLD 310 ++ +D + + + S+ P + + V+ Sbjct: 221 FDGEDEDELFQSIMEHNVSYPKSLSKEAVSICK--GLMTKHPAKRLGCGPEGERDVREHA 278 Query: 311 YTEKPLYENLRD 322 + + +E L + Sbjct: 279 FFRRIDWEKLEN 290 >4EQM-A nrPDB Length = 294 Score = 143 bits (360), Expect = 1e-34, Method: Composition-based stats. Identities = 44/246 (17%), Positives = 93/246 (37%), Gaps = 27/246 (10%) Query: 28 IITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFY 87 +I + + +K+ +G GG +YLA E + +K LK + Sbjct: 4 MIGKIINERYKIVDKLGGGGMSTVYLA-----EDTILNIKVAIKAIFIPPREKEETLKRF 58 Query: 88 QRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYEANA 146 +R + +L + + +++M+ G L + E++ Sbjct: 59 EREVH--------NSSQLSHQNIVSMIDV----DEEDDCYYLVMEYIEGPTLSEYIESHG 106 Query: 147 KRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCP 206 S T + + +ILD +++ H+ VH DIK N+L++ + + D+G+A Sbjct: 107 -PLSVDTAINFTNQILDGIKHAHDMRIVHRDIKPQNILIDSNKT--LKIFDFGIAKALSE 163 Query: 207 EGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLK 266 + + GT+++ S + G A D+ +G + + L G P+ Sbjct: 164 TSLTQTNH------VLGTVQYFSPEQAKGEATDECTDIYSIGIVLYEMLVGEPPFNGETA 217 Query: 267 DPKYVR 272 ++ Sbjct: 218 VSIAIK 223 >2JC6-A nrPDB Length = 334 Score = 143 bits (360), Expect = 1e-34, Method: Composition-based stats. Identities = 41/248 (16%), Positives = 81/248 (32%), Gaps = 28/248 (11%) Query: 33 AKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAK 92 KK ++ +G G F + LA+ ++ + + K + E+ ++ Sbjct: 20 IKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKH 79 Query: 93 PEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRK 152 + +L +++M ++ K Sbjct: 80 ENIVALEDIYESPNHL-------------------YLVMQLVSGGELFDRIVEKGFYTEK 120 Query: 153 TVLQLSLRILDILEYIHEHEYVHGDIKASNLL-LNYKNPDQVYLVDYGLAYRYCPEGVHK 211 L ++LD + Y+H VH D+K NLL + ++ + D+GL+ Sbjct: 121 DASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSK--------M 172 Query: 212 EYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYV 271 E K D GT + + + S+ D +G L G+ P+ D + Sbjct: 173 EGKGDVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFE 232 Query: 272 RDSKIRYR 279 + K Y Sbjct: 233 QILKAEYE 240 >3UDB-A nrPDB Length = 317 Score = 143 bits (359), Expect = 2e-34, Method: Composition-based stats. Identities = 40/243 (16%), Positives = 81/243 (33%), Gaps = 31/243 (12%) Query: 32 MAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAA 91 +++ IG G FG L ++ V +E + Sbjct: 16 HDSDRYELVKDIGAGNFGVARLMRDKQ----ANELVAVKYIERGEK-------------I 58 Query: 92 KPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSR 151 ++ I R L++ + ++ L ++ ++M+ NA RFS Sbjct: 59 DENVKREIINHRSLRHPNIVRFKEVIL----TPTHLAIVMEYASGGELFERICNAGRFSE 114 Query: 152 KTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHK 211 +++ + Y H + H D+K N LL+ ++ + D+G + Sbjct: 115 DEARFFFQQLISGVSYAHAMQVAHRDLKLENTLLDGSPAPRLKIADFGYSK--------A 166 Query: 212 EYKEDPKRCHDGTIEFTSIDAHNGVAPSRRG-DLEILGYCMIQWLTGHLPWEDNLKDPKY 270 + GT + + + + D+ G + L G P+ED ++PK Sbjct: 167 SVLHSQPKSAVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFED-PEEPKN 225 Query: 271 VRD 273 R Sbjct: 226 FRK 228 >5YKS-A nrPDB Length = 377 Score = 143 bits (359), Expect = 2e-34, Method: Composition-based stats. Identities = 39/244 (15%), Positives = 89/244 (36%), Gaps = 29/244 (11%) Query: 37 WKVGLPIGQGGFGCIYLAD-MNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQ 95 + + +G+G F + LA + + E V K++ G LF E++ + Sbjct: 37 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKL------ 90 Query: 96 IQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVL 155 +++ + + + + D K Y + + G D+ + + + Sbjct: 91 ---------VQHPNIVRLY--EVIDTQTKLYLILELG-DGGDMFDYIMKHEEGLNEDLAK 138 Query: 156 QLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKE 215 + +I+ + Y H+ VH D+K N++ K V L D+G + ++ P Sbjct: 139 KYFAQIVHAISYCHKLHVVHRDLKPENVVFFEK-QGLVKLTDFGFSNKFQP--------G 189 Query: 216 DPKRCHDGTIEFTSIDAHNGVAPSRR-GDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDS 274 G++ +++ + G D+ LG + + G P+++ Sbjct: 190 KKLTTSCGSLAYSAPEILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIM 249 Query: 275 KIRY 278 +Y Sbjct: 250 DCKY 253 >3ZUT-A nrPDB Length = 362 Score = 142 bits (358), Expect = 2e-34, Method: Composition-based stats. Identities = 40/243 (16%), Positives = 81/243 (33%), Gaps = 31/243 (12%) Query: 32 MAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAA 91 +++ IG G FG L S ++ V +E + Sbjct: 16 HDSDRYELVKDIGSGNFGVARLMRDKQS----NELVAVKYIERGEK-------------I 58 Query: 92 KPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSR 151 ++ I R L++ + ++ L ++ ++M+ NA RFS Sbjct: 59 DENVKREIINHRSLRHPNIVRFKEVIL----TPTHLAIVMEYASGGELFERICNAGRFSE 114 Query: 152 KTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHK 211 +++ + Y H + H D+K N LL+ ++ + +G + Sbjct: 115 DEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICAFGYSK--------S 166 Query: 212 EYKEDPKRCHDGTIEFTSIDAHNGVAPSRRG-DLEILGYCMIQWLTGHLPWEDNLKDPKY 270 + GT + + + + D+ G + L G P+ED ++PK Sbjct: 167 SVLHSQPKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFED-PEEPKN 225 Query: 271 VRD 273 R Sbjct: 226 FRK 228 >5J5T-A nrPDB Length = 370 Score = 142 bits (357), Expect = 3e-34, Method: Composition-based stats. Identities = 53/273 (19%), Positives = 105/273 (38%), Gaps = 36/273 (13%) Query: 33 AKKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAA 91 +++++++ IG G +G +Y A ++N+ E V+K+EP ++ + Sbjct: 2 SQEDFELIQRIGSGTYGDVYKARNVNTGELAAIK---VIKLEPGEDFAVVQ--------- 49 Query: 92 KPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGS-DLQKIYEANAKRFS 150 Q+ I + K+ + Y+GS L + ++ M+ G LQ IY S Sbjct: 50 -----QEIIMMKDCKHPNIVAYFGSYL----RRDKLWICMEFCGGGSLQDIYHVTG-PLS 99 Query: 151 RKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVH 210 + +S L L Y+H +H DIK +N+LL + V L D+G++ + Sbjct: 100 ELQIAYVSRETLQGLYYLHSKGKMHRDIKGANILLT--DNGHVKLADFGVSAQI------ 151 Query: 211 KEYKEDPKRCHDGTIEFTSIDAH---NGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKD 267 ++ GT + + + ++ DL +G I+ P D Sbjct: 152 -TATIAKRKAFIGTPYWMAPEVAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPM 210 Query: 268 PKYVRDSKIRYRENIASLMDKCFPEKNKPGEIA 300 +K ++ K + ++A Sbjct: 211 RALFLMTKSNFQPPKLKDKMKWSNSFHHFVKMA 243 >4APC-A nrPDB Length = 350 Score = 142 bits (357), Expect = 3e-34, Method: Composition-based stats. Identities = 42/249 (16%), Positives = 84/249 (33%), Gaps = 31/249 (12%) Query: 33 AKKEWKVGLPIGQGGFGCIYLADMNS-SESVGSDAPCVVKVEPSDNGPLFTELKFYQRAA 91 + +++ IG+G FG L + ++ + E+ Sbjct: 22 SMEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVL---- 77 Query: 92 KPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYEANAKR-F 149 +K+ + +Y S +++MD G DL K A F Sbjct: 78 -----------ANMKHPNIVQYRES----FEENGSLYIVMDYCEGGDLFKRINAQKGVLF 122 Query: 150 SRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGV 209 +L ++I L+++H+ + +H DIK+ N+ L V L D+G+A Sbjct: 123 QEDQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDGT--VQLGDFGIARVLNSTV- 179 Query: 210 HKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPK 269 + R GT + S + + + D+ LG + + T +E Sbjct: 180 ------ELARACIGTPYYLSPEICENKPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNL 233 Query: 270 YVRDSKIRY 278 ++ + Sbjct: 234 VLKIISGSF 242 >3Q53-A nrPDB Length = 306 Score = 142 bits (357), Expect = 3e-34, Method: Composition-based stats. Identities = 54/270 (20%), Positives = 100/270 (37%), Gaps = 36/270 (13%) Query: 34 KKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAK 92 KK++ IGQG G +Y A D+ + + V ++ Q+ K Sbjct: 20 KKKYTRFEKIGQGASGTVYTAMDVATGQEVA-----------------IRQMNLQQQPKK 62 Query: 93 PEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYEANAKRFSR 151 I + + R+ K + Y S L +++M+ G L + Sbjct: 63 ELIINEILVMRENKNPNIVNYLDSYLVGDE----LWVVMEYLAGGSLTDVV--TETCMDE 116 Query: 152 KTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHK 211 + + L LE++H ++ +H DIK+ N+LL V L D+G + PE Sbjct: 117 GQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGS--VKLTDFGFCAQITPE---- 170 Query: 212 EYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPW--EDNLKDPK 269 + + GT + + + A + D+ LG I+ + G P+ E+ L+ Sbjct: 171 ---QSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALY 227 Query: 270 YVRDSKIRYRENIASLMDKCFPEKNKPGEI 299 + + +N L N+ E+ Sbjct: 228 LIATNGTPELQNPEKLSAIFRDFLNRCLEM 257 >6FD3-A nrPDB Length = 300 Score = 142 bits (357), Expect = 3e-34, Method: Composition-based stats. Identities = 52/269 (19%), Positives = 99/269 (36%), Gaps = 34/269 (12%) Query: 34 KKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKP 93 KK++ IGQG G +Y A + + +K ++ Q+ K Sbjct: 21 KKKYTRFEKIGQGASGTVYTA-----LDIATGQEVAIK-----------QMNLQQQPKKE 64 Query: 94 EQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYEANAKRFSRK 152 I + + R+ K + Y S L +++M+ G L + Sbjct: 65 LIINEILVMRENKNPNIVNYLDSYLVGDE----LWVVMEYLAGGSLTDVV--TETCMDEG 118 Query: 153 TVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKE 212 + + L L+++H ++ +H DIK+ N+LL V L D+G + PE Sbjct: 119 QIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGS--VKLTDFGFCAQITPE----- 171 Query: 213 YKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPW--EDNLKDPKY 270 + + GT + + + A + D+ LG I+ + G P+ E+ L+ Sbjct: 172 --QSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYL 229 Query: 271 VRDSKIRYRENIASLMDKCFPEKNKPGEI 299 + + +N L N+ E+ Sbjct: 230 IATNGTPELQNPERLSAVFRDFLNRCLEM 258 >2BRG-A nrPDB Length = 297 Score = 142 bits (357), Expect = 3e-34, Method: Composition-based stats. Identities = 45/249 (18%), Positives = 95/249 (38%), Gaps = 33/249 (13%) Query: 35 KEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPE 94 ++W + +G+G +G + LA +E + +K + PE Sbjct: 7 EDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMK----------------RAVDCPE 50 Query: 95 QIQKWIRT-RKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYEANAKRFSRK 152 I+K I + L + V K++G + + +++ ++ G +L E + Sbjct: 51 NIKKEICINKMLNHENVVKFYGH----RREGNIQYLFLEYCSGGELFDRIEPDIG-MPEP 105 Query: 153 TVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKE 212 + +++ + Y+H H DIK NLLL+ ++ + + D+GLA + Sbjct: 106 DAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERD--NLKISDFGLATVFRYNN---- 159 Query: 213 YKEDPKRCHDGTIEFTSIDAHNGVA-PSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYV 271 +E GT+ + + + + D+ G + L G LPW+ Sbjct: 160 -RERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQ--PSDSCQ 216 Query: 272 RDSKIRYRE 280 S + ++ Sbjct: 217 EYSDWKEKK 225 >6BDL-A nrPDB Length = 347 Score = 141 bits (356), Expect = 3e-34, Method: Composition-based stats. Identities = 57/323 (17%), Positives = 108/323 (33%), Gaps = 46/323 (14%) Query: 36 EWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQ 95 ++ + +G GGFG + L + S ES +K+ + + E Sbjct: 35 DFNIIDTLGVGGFGRVELVQLKSEES----KTFAMKILKKRHIVDTRQQ---------EH 81 Query: 96 IQKWIRTRKLKYLG-VPKYWGSGLHDKNGKSYRFMIMD-RFGSDLQKIYEANAKRFSRKT 153 I+ + + + + + + + Y +M+M+ G +L I F T Sbjct: 82 IRSEKQIMQGAHSDFIVRLYRT----FKDSKYLYMLMEACLGGELWTILRDRGS-FEDST 136 Query: 154 VLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEY 213 + +++ Y+H ++ D+K NL+L+++ LVD+G A + Sbjct: 137 TRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGY--AKLVDFGFAKKIG-------- 186 Query: 214 KEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRD 273 GT E+ + + D LG M + LTG P+ DP Sbjct: 187 FGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSG--PDPMK--- 241 Query: 274 SKIRYRENIASLMDKCFPEKNKPGEIAK-YMETVKLLDYTEKPLYENLRDILLQGLKAIG 332 +++ + P +IAK +K L E L ++ Sbjct: 242 --------TYNIILRGIDMIEFPKKIAKNAANLIKKLCRDN--PSERLGNLKNGVKDIQK 291 Query: 333 SKDDGKLDLSVVENGGLKAKTIT 355 K + + G L I Sbjct: 292 HKWFEGFNWEGLRKGTLTPPIIP 314 >3PFQ-A nrPDB Length = 674 Score = 141 bits (356), Expect = 4e-34, Method: Composition-based stats. Identities = 45/306 (14%), Positives = 97/306 (31%), Gaps = 45/306 (14%) Query: 32 MAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAA 91 M ++ + +G+G FG + L SE G+D VK+ D +++ Sbjct: 338 MKLTDFNFLMVLGKGSFGKVML-----SERKGTDELYAVKILKKDVVIQDDDVEC----- 387 Query: 92 KPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSR 151 + R L G P + + +M+ + RF Sbjct: 388 ------TMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKE 441 Query: 152 KTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHK 211 + + I L ++ ++ D+K N++L+ + + + D+G+ +GV Sbjct: 442 PHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEG--HIKIADFGMCKENIWDGV-- 497 Query: 212 EYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYV 271 + GT ++ + + + D G + + L G P+E +D + Sbjct: 498 -----TTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQ 552 Query: 272 RDSK------IRYRENIASLM-----------DKCFPEKNKPGEIAKYMETVKLLDYTEK 314 + + ++ C PE + + + + K Sbjct: 553 SIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERK 612 Query: 315 ---PLY 317 P Y Sbjct: 613 EIQPPY 618 >6QAU-A nrPDB Length = 280 Score = 141 bits (356), Expect = 4e-34, Method: Composition-based stats. Identities = 40/257 (15%), Positives = 83/257 (32%), Gaps = 35/257 (13%) Query: 36 EWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQ 95 E+ +G G F ++ + K S + L Sbjct: 12 EYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLG------------- 58 Query: 96 IQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYEANAKRFSRKTV 154 ++ ++L++ + + + + F++M+ G DL +A S T+ Sbjct: 59 -KEIKILKELQHENIVALYDV----QELPNSVFLVMEYCNGGDLADYLQAKG-TLSEDTI 112 Query: 155 LQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQ-------VYLVDYGLAYRYCPE 207 +I + +H +H D+K N+LL+Y N + + + D+G A Sbjct: 113 RVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSN 172 Query: 208 GVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKD 267 + G+ + + + + DL +G + Q L G P++ N Sbjct: 173 MM--------AADLCGSPMYMAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQ 224 Query: 268 PKYVRDSKIRYRENIAS 284 + K R Sbjct: 225 DLRMFYEKNRSLMPSIP 241 >2I0E-A nrPDB Length = 353 Score = 141 bits (355), Expect = 5e-34, Method: Composition-based stats. Identities = 45/306 (14%), Positives = 97/306 (31%), Gaps = 45/306 (14%) Query: 32 MAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAA 91 M ++ + +G+G FG + L SE G+D VK+ D +++ Sbjct: 17 MKLTDFNFLMVLGKGSFGKVML-----SERKGTDELYAVKILKKDVVIQDDDVEC----- 66 Query: 92 KPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSR 151 + R L G P + + +M+ + RF Sbjct: 67 ------TMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKE 120 Query: 152 KTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHK 211 + + I L ++ ++ D+K N++L+ + + + D+G+ +GV Sbjct: 121 PHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEG--HIKIADFGMCKENIWDGV-- 176 Query: 212 EYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYV 271 + GT ++ + + + D G + + L G P+E +D + Sbjct: 177 -----TTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQ 231 Query: 272 RDSK------IRYRENIASLM-----------DKCFPEKNKPGEIAKYMETVKLLDYTEK 314 + + ++ C PE + + + + K Sbjct: 232 SIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERK 291 Query: 315 ---PLY 317 P Y Sbjct: 292 EIQPPY 297 >4JG6-A nrPDB Length = 355 Score = 141 bits (355), Expect = 5e-34, Method: Composition-based stats. Identities = 47/306 (15%), Positives = 93/306 (30%), Gaps = 50/306 (16%) Query: 35 KEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPE 94 ++V IG G + ++ VK+ E++ R + Sbjct: 35 DGYEVKEDIGVGSYSVCKRCIHK-----ATNMEFAVKIIDKSKRDPTEEIEILLRYGQ-- 87 Query: 95 QIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTV 154 + + + Y +++ + K FS + Sbjct: 88 ------------HPNIITLKDVY----DDGKYVYVVTELMKGGELLDKILRQKFFSEREA 131 Query: 155 LQLSLRILDILEYIHEHEYVHGDIKASNLLL--NYKNPDQVYLVDYGLAYRYCPEGVHKE 212 + I +EY+H VH D+K SN+L NP+ + + D+G A + E Sbjct: 132 SAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAE----- 186 Query: 213 YKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYV- 271 T F + + D+ LG + LTG+ P+ + D Sbjct: 187 --NGLLMTPCYTANFVAPEVLERQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEI 244 Query: 272 --RDSKIRYR-------------ENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPL 316 R ++ +++ S M P + A + ++ + + P Sbjct: 245 LARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTA--ALVLRHPWIVHWDQLPQ 302 Query: 317 YENLRD 322 Y+ R Sbjct: 303 YQLNRQ 308 >2YAB-A nrPDB Length = 361 Score = 141 bits (355), Expect = 5e-34, Method: Composition-based stats. Identities = 41/251 (16%), Positives = 86/251 (34%), Gaps = 26/251 (10%) Query: 32 MAKKEWKVGLPIGQGGFGCIYLADMN-SSESVGSDAPCVVKVEPSDNGPLFTELKFYQRA 90 + + +G +G G F + + + + S G E++ Sbjct: 9 KVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIE----- 63 Query: 91 AKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFS 150 ++ R++ + + ++ +I++ + A + S Sbjct: 64 ------REVSILRQVLHPNIITLHDVY----ENRTDVVLILELVSGGELFDFLAQKESLS 113 Query: 151 RKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKN--PDQVYLVDYGLAYRYCPEG 208 + +ILD + Y+H + H D+K N++L KN + L+D+GLA Sbjct: 114 EEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLA------- 166 Query: 209 VHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDP 268 H+ + GT EF + + N D+ +G L+G P+ + K Sbjct: 167 -HEIEDGVEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQE 225 Query: 269 KYVRDSKIRYR 279 + + Y Sbjct: 226 TLANITAVSYD 236 >5F9E-A nrPDB Length = 353 Score = 141 bits (355), Expect = 5e-34, Method: Composition-based stats. Identities = 41/265 (15%), Positives = 93/265 (35%), Gaps = 37/265 (13%) Query: 35 KEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPE 94 +++++ +G+G FG ++LA+ + + +K D + +++ Sbjct: 19 EDFELHKMLGKGSFGKVFLAEFKKT-----NQFFAIKALKKDVVLMDDDVEC-------- 65 Query: 95 QIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYEANAKRFSRKT 153 + R L + K F +M+ G DL ++ K F Sbjct: 66 ---TMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHK-FDLSR 121 Query: 154 VLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEY 213 + I+ L+++H V+ D+K N+LL+ + + D+G+ Sbjct: 122 ATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDG--HIKIADFGMCKENM-------L 172 Query: 214 KEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDN--------- 264 + GT ++ + + G + D G + + L G P+ Sbjct: 173 GDAKTNEFCGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSI 232 Query: 265 -LKDPKYVRDSKIRYRENIASLMDK 288 + +P Y R + ++ + L + Sbjct: 233 RMDNPFYPRWLEKEAKDLLVKLFVR 257 >3NIZ-A nrPDB Length = 311 Score = 141 bits (355), Expect = 5e-34, Method: Composition-based stats. Identities = 41/288 (14%), Positives = 98/288 (34%), Gaps = 39/288 (13%) Query: 34 KKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKP 93 ++++ +G+G +G +Y A + V ++++ D G Sbjct: 20 MEKYQKLEKVGEGTYGVVYKAKDSQGRIVALKR---IRLDAEDEG------------IPS 64 Query: 94 EQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKT 153 I++ ++L + + ++ ++ + DL+K+ + N Sbjct: 65 TAIREISLLKELHHPNIVSLIDVIHSER----CLTLVFEFMEKDLKKVLDENKTGLQDSQ 120 Query: 154 VLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEY 213 + ++L + + H+H +H D+K NLL+N + L D+GLA + Sbjct: 121 IKIYLYQLLRGVAHCHQHRILHRDLKPQNLLINSDG--ALKLADFGLARAFG-------I 171 Query: 214 KEDPKRCHDGTIEFTSIDAHNG-VAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVR 272 T+ + + D G S D+ +G + +TG + D + + Sbjct: 172 PVRSYTHEVVTLWYRAPDVLMGSKKYSTSVDIWSIGCIFAEMITGKPLFPGVTDDDQLPK 231 Query: 273 DSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENL 320 + + + P + + EK + ++ Sbjct: 232 I----FSILGTPNPREWPQVQELP------LWKQRTFQVFEKKPWSSI 269 >6E9W-A nrPDB Length = 443 Score = 140 bits (353), Expect = 9e-34, Method: Composition-based stats. Identities = 44/247 (17%), Positives = 85/247 (34%), Gaps = 32/247 (12%) Query: 32 MAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAA 91 M ++++V IG+G FG + L S+ V +K+ ++ F+ Sbjct: 99 MKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVY-----AMKLLSKFEMIKRSDSAFF---- 149 Query: 92 KPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYEANAKRFS 150 R + + + Y +M+M+ G DL + Sbjct: 150 --------WEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD--VP 199 Query: 151 RKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVH 210 K + ++ L+ IH ++H D+K N+LL+ + L D+G + EG+ Sbjct: 200 EKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSG--HLKLADFGTCMKMNKEGMV 257 Query: 211 KEYKEDPKRCHDGTIEFTSIDAHNGVA----PSRRGDLEILGYCMIQWLTGHLPWEDNLK 266 GT ++ S + R D +G + + L G P+ + Sbjct: 258 ------RCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSL 311 Query: 267 DPKYVRD 273 Y + Sbjct: 312 VGTYSKI 318 >2PL0-A nrPDB Length = 289 Score = 140 bits (353), Expect = 9e-34, Method: Composition-based stats. Identities = 49/319 (15%), Positives = 120/319 (37%), Gaps = 47/319 (14%) Query: 16 KRHLAEQFAVGEIITD---MAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKV 72 H+ Q D + ++ K+ +G G FG +++ N V + + Sbjct: 1 GSHMQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSM 60 Query: 73 EPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMD 132 P E ++ ++ L+ + ++I + Sbjct: 61 SP---DAFLAEANLMKQLQHQRLVR--------------------LYAVVTQEPIYIITE 97 Query: 133 RF-GSDLQKIYE-ANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNP 190 L + + + + +L ++ +I + + +I E Y+H D++A+N+L++ + Sbjct: 98 YMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVS--DT 155 Query: 191 DQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYC 250 + D+GLA ++ + + I++T+ +A N + + D+ G Sbjct: 156 LSCKIADFGLARLI------EDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGIL 209 Query: 251 MIQWLT-GHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLL 309 + + +T G +P+ + +P+ +++ + YR N P E+ + M Sbjct: 210 LTEIVTHGRIPY-PGMTNPEVIQNLERGYR---------MVRPDNCPEELYQLMRLCWKE 259 Query: 310 DYTEKPLYENLRDILLQGL 328 ++P ++ LR +L Sbjct: 260 RPEDRPTFDYLRSVLEDFF 278 >5KCV-A nrPDB Length = 460 Score = 140 bits (352), Expect = 1e-33, Method: Composition-based stats. Identities = 44/281 (15%), Positives = 98/281 (34%), Gaps = 34/281 (12%) Query: 11 RQSSAKRHLAEQFA---VGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAP 67 R S + + + + + E++ +G+G FG + L + + Sbjct: 135 RSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILV-----KEKATGRY 189 Query: 68 CVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKY-WGSGLHDKNGKSY 126 +K+ + E+ + + + ++ + + HD+ Sbjct: 190 YAMKILKKEVIVAKDEVA--------HTLTENRVLQNSRHPFLTALKYSFQTHDRLCF-- 239 Query: 127 RFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHE-HEYVHGDIKASNLLL 185 +M+ + + + FS I+ L+Y+H V+ D+K NL+L Sbjct: 240 ---VMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLML 296 Query: 186 NYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLE 245 + + + D+GL +G + GT E+ + + R D Sbjct: 297 DKDG--HIKITDFGLCKEGIKDG-------ATMKTFCGTPEYLAPEVLEDNDYGRAVDWW 347 Query: 246 ILGYCMIQWLTGHLPW--EDNLKDPKYVRDSKIRYRENIAS 284 LG M + + G LP+ +D+ K + + +IR+ + Sbjct: 348 GLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGP 388 >4FG9-A nrPDB Length = 320 Score = 139 bits (351), Expect = 1e-33, Method: Composition-based stats. Identities = 39/244 (15%), Positives = 81/244 (33%), Gaps = 28/244 (11%) Query: 37 WKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQI 96 + +G G F + LA+ ++ + + + G + E+ + P + Sbjct: 20 YDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMENEIAVLHKIKHPNIV 79 Query: 97 QKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQ 156 +L ++IM ++ + + Sbjct: 80 ALDDIYESGGHL-------------------YLIMQLVSGGELFDRIVEKGFYTERDASR 120 Query: 157 LSLRILDILEYIHEHEYVHGDIKASNLL-LNYKNPDQVYLVDYGLAYRYCPEGVHKEYKE 215 L ++LD ++Y+H+ VH D+K NLL + ++ + D+GL+ P V Sbjct: 121 LIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSV------ 174 Query: 216 DPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSK 275 GT + + + S+ D +G L G+ P+ D + + K Sbjct: 175 --LSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILK 232 Query: 276 IRYR 279 Y Sbjct: 233 AEYE 236 >3TXO-A nrPDB Length = 353 Score = 139 bits (351), Expect = 1e-33, Method: Composition-based stats. Identities = 49/334 (14%), Positives = 108/334 (32%), Gaps = 40/334 (11%) Query: 35 KEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPE 94 ++ +G+G FG + LA + + + VKV D + E Sbjct: 23 DNFEFIRVLGKGSFGKVMLARVKETGDLY-----AVKVLKKD---------VILQDDDVE 68 Query: 95 QIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTV 154 R L + F +M+ + ++RF Sbjct: 69 CTMTEKRILSLARNH--PFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARA 126 Query: 155 LQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYK 214 + I+ L ++H+ ++ D+K N+LL+++ L D+G+ GV Sbjct: 127 RFYAAEIISALMFLHDKGIIYRDLKLDNVLLDHEG--HCKLADFGMCKEGICNGV----- 179 Query: 215 EDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDS 274 GT ++ + + + D +G + + L GH P+E +D + Sbjct: 180 --TTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAIL 237 Query: 275 KIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDILLQGLKAIGSK 334 D K+ + ++L T+ + LR + Sbjct: 238 NDEVVYPTWLHEDATGILKSFMTKNPT----MRLGSLTQGGEHAILRHPFFK-------- 285 Query: 335 DDGKLDLSVVENGGLKAKTITKKRKKEIEESKEP 368 ++D + + + ++ + + +E + +P Sbjct: 286 ---EIDWAQLNHRQIEPPFRPRIKSREDVSNFDP 316 >5YV8-A nrPDB Length = 298 Score = 139 bits (351), Expect = 1e-33, Method: Composition-based stats. Identities = 41/247 (16%), Positives = 88/247 (35%), Gaps = 29/247 (11%) Query: 32 MAKKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELK----- 85 + ++ + IG+G +G + LA + N + K+ P + Sbjct: 10 VQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPA 69 Query: 86 ----FYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF--GSDLQ 139 R + Q+ +KL + V K + D + + +M+ + G ++ Sbjct: 70 PGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLV--EVLDDPNEDHLYMVFELVNQGPVME 127 Query: 140 KIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYG 199 K S ++ +EY+H + +H DIK SNLL+ + + D+G Sbjct: 128 ---VPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDG--HIKIADFG 182 Query: 200 LAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAH---NGVAPSRRGDLEILGYCMIQWLT 256 ++ + GT F + ++ + + D+ +G + ++ Sbjct: 183 VSNEFKGSD-------ALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVF 235 Query: 257 GHLPWED 263 G P+ D Sbjct: 236 GQCPFMD 242 >2A27-A nrPDB Length = 321 Score = 139 bits (351), Expect = 1e-33, Method: Composition-based stats. Identities = 42/250 (16%), Positives = 85/250 (34%), Gaps = 24/250 (9%) Query: 32 MAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAA 91 + + +G +G G F + S+ K + + Sbjct: 9 KVEDFYDIGEELGSGQFAIVKKCREKST-----GLEYAAKFIKKRQSRASR-----RGVS 58 Query: 92 KPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSR 151 + E ++ R++ + V ++ +I++ + A + S Sbjct: 59 REEIEREVSILRQVLHHNVITLHDVY----ENRTDVVLILELVSGGELFDFLAQKESLSE 114 Query: 152 KTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKN--PDQVYLVDYGLAYRYCPEGV 209 + +ILD + Y+H + H D+K N++L KN + L+D+GLA Sbjct: 115 EEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLA-------- 166 Query: 210 HKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPK 269 H+ + GT EF + + N D+ +G L+G P+ + K Sbjct: 167 HEIEDGVEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQET 226 Query: 270 YVRDSKIRYR 279 + + Y Sbjct: 227 LANITAVSYD 236 >3MV5-A nrPDB Length = 342 Score = 139 bits (350), Expect = 2e-33, Method: Composition-based stats. Identities = 43/263 (16%), Positives = 94/263 (35%), Gaps = 31/263 (11%) Query: 26 GEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELK 85 G + + E++ +G+G FG + L + + +K+ + E+ Sbjct: 1 GAMDPRVTMNEFEYLKLLGKGTFGKVILV-----KEKATGRYYAMKILKKEVIVAKDEVA 55 Query: 86 FYQRAAKPEQIQKWIRTRKLKYLGVPKY-WGSGLHDKNGKSYRFMIMDRFGSDLQKIYEA 144 + + + ++ + + HD+ +M+ + + Sbjct: 56 --------HTLTENRVLQNSRHPFLTALKYSFQTHDRLCF-----VMEYANGGELFFHLS 102 Query: 145 NAKRFSRKTVLQLSLRILDILEYIHE-HEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYR 203 + FS I+ L+Y+H V+ D+K NL+L+ + + D+GL Sbjct: 103 RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDG--HIKITDFGLCKE 160 Query: 204 YCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPW-- 261 +G + GT E+ + + R D LG M + + G LP+ Sbjct: 161 GIKDG-------ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYN 213 Query: 262 EDNLKDPKYVRDSKIRYRENIAS 284 +D+ K + + +IR+ + Sbjct: 214 QDHEKLFELILMEEIRFPRTLGP 236 >1ZWS-A nrPDB Length = 288 Score = 139 bits (350), Expect = 2e-33, Method: Composition-based stats. Identities = 42/250 (16%), Positives = 85/250 (34%), Gaps = 24/250 (9%) Query: 32 MAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAA 91 + + +G +G G F + S+ K + + Sbjct: 9 KVEDFYDIGEELGSGQFAIVKKCREKST-----GLEYAAKFIKKRQSRASR-----RGVS 58 Query: 92 KPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSR 151 + E ++ R++ + V ++ +I++ + A + S Sbjct: 59 REEIEREVSILRQVLHHNVITLHDVY----ENRTDVVLILELVSGGELFDFLAQKESLSE 114 Query: 152 KTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKN--PDQVYLVDYGLAYRYCPEGV 209 + +ILD + Y+H + H D+K N++L KN + L+D+GLA Sbjct: 115 EEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLA-------- 166 Query: 210 HKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPK 269 H+ + GT EF + + N D+ +G L+G P+ + K Sbjct: 167 HEIEDGVEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQET 226 Query: 270 YVRDSKIRYR 279 + + Y Sbjct: 227 LANITSVSYD 236 >6ED6-A nrPDB Length = 415 Score = 139 bits (350), Expect = 2e-33, Method: Composition-based stats. Identities = 44/275 (16%), Positives = 84/275 (30%), Gaps = 32/275 (11%) Query: 32 MAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAA 91 M +++ V IG+G FG + L S +K+ ++ F+ Sbjct: 85 MKAEDYDVVKVIGRGAFGEVQLVRHK-----ASQKVYAMKLLSKFEMIKRSDSAFF---- 135 Query: 92 KPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYEANAKRFS 150 R + + + Y +M+M+ G DL + Sbjct: 136 --------WEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD--VP 185 Query: 151 RKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVH 210 K + ++ L+ IH +H D+K N+LL+ + L D+G + G+ Sbjct: 186 EKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHG--HLKLADFGTCMKMDETGMV 243 Query: 211 KEYKEDPKRCHDGTIEFTSIDAHNGVA----PSRRGDLEILGYCMIQWLTGHLPWEDNLK 266 GT ++ S + R D +G + + L G P+ + Sbjct: 244 H------CDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSL 297 Query: 267 DPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAK 301 Y + + + KN Sbjct: 298 VGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLT 332 >3A8W-A nrPDB Length = 345 Score = 139 bits (349), Expect = 2e-33, Method: Composition-based stats. Identities = 40/230 (17%), Positives = 85/230 (36%), Gaps = 27/230 (11%) Query: 34 KKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKP 93 +++ + IG+G + + L + ++ + + ++ D + Sbjct: 8 LQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWV----------- 56 Query: 94 EQIQKWIRTRKLKYLGVPKYWGSGLHD-KNGKSYRFMIMDRFGSDLQKIYEANAKRFSRK 152 Q +K + + + + GLH +S F +++ + ++ + Sbjct: 57 -QTEKHVFEQASNHP-----FLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEE 110 Query: 153 TVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKE 212 S I L Y+HE ++ D+K N+LL+ + + L DYG+ C EG+ Sbjct: 111 HARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEG--HIKLTDYGM----CKEGLR-- 162 Query: 213 YKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWE 262 D GT + + + G D LG M + + G P++ Sbjct: 163 -PGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFD 211 >2JAM-A nrPDB Length = 304 Score = 138 bits (348), Expect = 3e-33, Method: Composition-based stats. Identities = 35/247 (14%), Positives = 80/247 (32%), Gaps = 32/247 (12%) Query: 35 KEWKVGLPIGQGGFGCIYLADMN-SSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKP 93 K + +G G F ++L + + C+ K + L E+ ++ Sbjct: 9 KTFIFMEVLGSGAFSEVFLVKQRLTGKLFALK--CIKKSPAFRDSSLENEIAVLKKIKHE 66 Query: 94 EQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKT 153 + + +++M ++ K Sbjct: 67 NIVTLEDIYESTTH-------------------YYLVMQLVSGGELFDRILERGVYTEKD 107 Query: 154 VLQLSLRILDILEYIHEHEYVHGDIKASNLL-LNYKNPDQVYLVDYGLAYRYCPEGVHKE 212 + ++L ++Y+HE+ VH D+K NLL L + ++ + D+GL+ + Sbjct: 108 ASLVIQQVLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIM--- 164 Query: 213 YKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVR 272 GT + + + S+ D +G L G+ P+ + + + + Sbjct: 165 ------STACGTPGYVAPEVLAQKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEK 218 Query: 273 DSKIRYR 279 + Y Sbjct: 219 IKEGYYE 225 >4FZF-B nrPDB Length = 283 Score = 138 bits (347), Expect = 4e-33, Method: Composition-based stats. Identities = 46/224 (20%), Positives = 85/224 (37%), Gaps = 29/224 (12%) Query: 37 WKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQI 96 + IG+G FG ++ N ++ V + ++ + + E+ + Sbjct: 10 FTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSS--- 66 Query: 97 QKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQ 156 V KY+GS L S ++IM+ G + A F + Sbjct: 67 ------------YVTKYYGSYLK----GSKLWIIMEYLGGG-SALDLLRAGPFDEFQIAT 109 Query: 157 LSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKED 216 + IL L+Y+H + +H DIKA+N+LL+ + V L +G+A + + Sbjct: 110 MLKEILKGLDYLHSEKKIHRDIKAANVLLSEQG--DVKLAAFGVAGQLTDTQI------- 160 Query: 217 PKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLP 260 + GT + + + A + D+ LG I+ G P Sbjct: 161 KRNTFVGTPFWMAPEVIQQSAYDSKADIWSLGITAIELAKGEPP 204 >3F3Z-A nrPDB Length = 277 Score = 138 bits (347), Expect = 4e-33, Method: Composition-based stats. Identities = 41/243 (16%), Positives = 81/243 (33%), Gaps = 30/243 (12%) Query: 37 WKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQI 96 + + IG+G +G + +A G+ K P K Sbjct: 11 YTLENTIGRGSWGEVKIAVQK-----GTRIRRAAKKIPKYFVEDVDRFK----------- 54 Query: 97 QKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQ 156 Q+ + L + + + + + +++M+ + + F + Sbjct: 55 QEIEIMKSLDHPNIIRLY----ETFEDNTDIYLVMELCTGGELFERVVHKRVFRESDAAR 110 Query: 157 LSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQ-VYLVDYGLAYRYCPEGVHKEYKE 215 + +L + Y H+ H D+K N L +PD + L+D+GLA R+ P + Sbjct: 111 IMKDVLSAVAYCHKLNVAHRDLKPENFLFLTDSPDSPLKLIDFGLAARFKPGKMM----- 165 Query: 216 DPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSK 275 R GT + S G+ D G M L G+ P+ ++ + Sbjct: 166 ---RTKVGTPYYVSPQVLEGLY-GPECDEWSAGVMMYVLLCGYPPFSAPTDSEVMLKIRE 221 Query: 276 IRY 278 + Sbjct: 222 GTF 224 >3PPZ-A nrPDB Length = 309 Score = 138 bits (347), Expect = 4e-33, Method: Composition-based stats. Identities = 45/294 (15%), Positives = 96/294 (32%), Gaps = 47/294 (15%) Query: 39 VGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQK 98 + IG G FG ++ A+ + V E+ +R Sbjct: 41 IKEKIGAGSFGTVHRAEWH-GSDVAVKILMEQDFHAERVNEFLREVAIMKR--------- 90 Query: 99 WIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFG-SDLQKIYEANAKR--FSRKTVL 155 L++ + + G+ ++ + L ++ + R + L Sbjct: 91 ------LRHPNIVLFMGA----VTQPPNLSIVTEYLSRGSLYRLLHKSGAREQLDERRRL 140 Query: 156 QLSLRILDILEYIHEHE--YVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEY 213 ++ + + Y+H VH D+K+ NLL++ K V + D+GL+ K Sbjct: 141 SMAYDVAKGMNYLHNRNPPIVHRDLKSPNLLVDKK--YTVKVCDFGLSRL-------KAS 191 Query: 214 KEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRD 273 + GT E+ + + + + D+ G + + T PW + Sbjct: 192 TFLSSKSAAGTPEWMAPEVLRDEPSNEKSDVYSFGVILWELATLQQPWGNLNPAQVVAAV 251 Query: 274 S--------KIRYRENIASLMDKCF---PEKNKPGEIAKYMETVKLLDYTEKPL 316 +A++++ C+ P K A M+ ++ L + P Sbjct: 252 GFKCKRLEIPRNLNPQVAAIIEGCWTNEPWKRPS--FATIMDLLRPLIKSAVPP 303 >2YCR-A nrPDB Length = 323 Score = 138 bits (346), Expect = 5e-33, Method: Composition-based stats. Identities = 37/234 (15%), Positives = 84/234 (35%), Gaps = 25/234 (10%) Query: 35 KEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPE 94 E+ + +G G G + LA + +K+ + + + Sbjct: 10 DEYIMSKTLGSGACGEVKLAFERKT-----CKKVAIKIISKRKFAIGSAREADPALNVET 64 Query: 95 QIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTV 154 +I+ +KL + + K + +++++ KR T Sbjct: 65 EIEI---LKKLNHPCIIKI-----KNFFDAEDYYIVLELMEGGELFDKVVGNKRLKEATC 116 Query: 155 LQLSLRILDILEYIHEHEYVHGDIKASNLLLNY-KNPDQVYLVDYGLAYRYCPEGVHKEY 213 ++L ++Y+HE+ +H D+K N+LL+ + + + D+G + + Sbjct: 117 KLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLM--- 173 Query: 214 KEDPKRCHDGTIEFTSIDAHNGV---APSRRGDLEILGYCMIQWLTGHLPWEDN 264 R GT + + + V +R D LG + L+G+ P+ ++ Sbjct: 174 -----RTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEH 222 >5VO2-A nrPDB Length = 300 Score = 137 bits (345), Expect = 7e-33, Method: Composition-based stats. Identities = 46/291 (15%), Positives = 94/291 (32%), Gaps = 50/291 (17%) Query: 43 IGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRT 102 +G G G ++L + E V +K Sbjct: 20 VGSGAQGAVFLGRFH-GEEVAVKKVRDLKET------------------------DIKHL 54 Query: 103 RKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRIL 162 RKLK+ + + G ++M+ + + ++ S+ I Sbjct: 55 RKLKHPNIITFKGV----CTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIA 110 Query: 163 DILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHD 222 + Y+H H+ +H D+K+ N+L+ Y + V + D+G + + K Sbjct: 111 GGMNYLHLHKIIHRDLKSPNMLITYDD--VVKISDFGTSKELSDKST--------KMSFA 160 Query: 223 GTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRYRENI 282 GT+ + + + S + D+ G + + LTG +P++D + Sbjct: 161 GTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPV 220 Query: 283 AS--------LMDKCFPEK--NKPGEIAKYMET-VKLLDYTEKPLYENLRD 322 S L+ +C+ K N+P + + D P + Sbjct: 221 PSSCPDGFKILLRQCWNSKPRNRPSFRQILLHLDIASADVLSTPQETYFKS 271 >2W4O-A nrPDB Length = 349 Score = 137 bits (345), Expect = 7e-33, Method: Composition-based stats. Identities = 50/271 (18%), Positives = 93/271 (34%), Gaps = 39/271 (14%) Query: 3 RVKAAQAGRQSSAKRHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESV 62 + ++ + L + + D ++V +G+G +Y + Sbjct: 21 QSMSSVTASAAPGTASLVPDYWIDGSNRDALSDFFEVESELGRGATSIVYRC-----KQK 75 Query: 63 GSDAPCVVKVEPS--DNGPLFTELKFYQRAAKPE--QIQKWIRTRKLKYLGVPKYWGSGL 118 G+ P +KV D + TE+ R + P ++++ T L + G L Sbjct: 76 GTQKPYALKVLKKTVDKKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLELVTGGEL 135 Query: 119 HDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDI 178 D+ +S + +IL+ + Y+HE+ VH D+ Sbjct: 136 FDRI---------------------VEKGYYSERDAADAVKQILEAVAYLHENGIVHRDL 174 Query: 179 KASNLLLNYKNPDQ-VYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVA 237 K NLL PD + + D+GL+ + + K GT + + + G A Sbjct: 175 KPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTV--------CGTPGYCAPEILRGCA 226 Query: 238 PSRRGDLEILGYCMIQWLTGHLPWEDNLKDP 268 D+ +G L G P+ D D Sbjct: 227 YGPEVDMWSVGIITYILLCGFEPFYDERGDQ 257 >3I6U-A nrPDB Length = 419 Score = 137 bits (344), Expect = 9e-33, Method: Composition-based stats. Identities = 36/234 (15%), Positives = 84/234 (35%), Gaps = 25/234 (10%) Query: 35 KEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPE 94 E+ + +G G G + LA + +++ + + + Sbjct: 135 DEYIMSKTLGSGACGEVKLAFERKT-----CKKVAIRIISKRKFAIGSAREADPALNVET 189 Query: 95 QIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTV 154 +I+ +KL + + K + +++++ KR T Sbjct: 190 EIEI---LKKLNHPCIIKI-----KNFFDAEDYYIVLELMEGGELFDKVVGNKRLKEATC 241 Query: 155 LQLSLRILDILEYIHEHEYVHGDIKASNLLLNY-KNPDQVYLVDYGLAYRYCPEGVHKEY 213 ++L ++Y+HE+ +H D+K N+LL+ + + + D+G + + Sbjct: 242 KLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLM--- 298 Query: 214 KEDPKRCHDGTIEFTSIDAHNGV---APSRRGDLEILGYCMIQWLTGHLPWEDN 264 R GT + + + V +R D LG + L+G+ P+ ++ Sbjct: 299 -----RTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEH 347 >4AW2-A nrPDB Length = 437 Score = 137 bits (344), Expect = 9e-33, Method: Composition-based stats. Identities = 46/251 (18%), Positives = 93/251 (37%), Gaps = 31/251 (12%) Query: 35 KEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPE 94 +++++ IG+G FG + VVK++ +D L ++ + E Sbjct: 74 EDFEILKVIGRGAFGEV----------------AVVKLKNADKVFAMKILNKWEMLKRAE 117 Query: 95 QIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDR-FGSDLQKIYEANAKRFSRKT 153 + R + G K+ + + + +++MD G DL + R + Sbjct: 118 TA-CFREERDVLVNGDSKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEEM 176 Query: 154 VLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEY 213 ++ ++ +H+ YVH DIK N+L++ + L D+G + +G + Sbjct: 177 ARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNG--HIRLADFGSCLKLMEDGTVQSS 234 Query: 214 KEDPKRCHDGTIEFTSIDAHNGVAPSR-----RGDLEILGYCMIQWLTGHLPWEDNLKDP 268 GT ++ S + + + D LG CM + L G P+ Sbjct: 235 ------VAVGTPDYISPEILQAMEGGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVE 288 Query: 269 KYVRDSKIRYR 279 Y + + R Sbjct: 289 TYGKIMNHKER 299 >4UY9-A nrPDB Length = 323 Score = 137 bits (344), Expect = 9e-33, Method: Composition-based stats. Identities = 57/307 (18%), Positives = 105/307 (34%), Gaps = 55/307 (17%) Query: 43 IGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRT 102 IG GGFG +Y A VK D ++ Q+ Sbjct: 17 IGIGGFGKVYRA-------FWIGDEVAVKAARHDPDEDISQ-------TIENVRQEAKLF 62 Query: 103 RKLKYLGVPKYWGSGLHDKNGKSYRFMIMDR-FGSDLQKIYEANAKRFSRKTVLQLSLRI 161 LK+ + G L + ++M+ G L ++ + KR ++ +++I Sbjct: 63 AMLKHPNIIALRGVCLKE----PNLCLVMEFARGGPLNRVL--SGKRIPPDILVNWAVQI 116 Query: 162 LDILEYIHEHEY---VHGDIKASNLLLNYK------NPDQVYLVDYGLAYRYCPEGVHKE 212 + Y+H+ +H D+K+SN+L+ K + + + D+GLA E Sbjct: 117 ARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAR---------E 167 Query: 213 YKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVR 272 + K GT + + + S+ D+ G + + LTG +P+ D V Sbjct: 168 WHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGI--DGLAVA 225 Query: 273 DSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDILLQGLKAIG 332 + + + C P AK ME D +P L + Sbjct: 226 YG-VAMNKLALPIPSTC------PEPFAKLMEDCWNPDPHSRPS-------FTNILDQLT 271 Query: 333 SKDDGKL 339 + ++ Sbjct: 272 TIEESGF 278 >6BXI-A nrPDB Length = 333 Score = 137 bits (344), Expect = 1e-32, Method: Composition-based stats. Identities = 51/352 (14%), Positives = 99/352 (28%), Gaps = 71/352 (20%) Query: 34 KKEWKVGLPIGQGGFGCIYLADMNSSESVG--SDAPCVVKVEPSDNGPLFTELKFYQRAA 91 ++++ IG+G FG + L + V +E G + E A Sbjct: 5 LEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEAD 64 Query: 92 KPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSR 151 + + K ++IM+ + Sbjct: 65 S-------------------LWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTE 105 Query: 152 KTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHK 211 + + ++ IH+ ++H DIK NLLL+ K V L D+GL + Sbjct: 106 EETQFYIAETVLAIDSIHQLGFIHRDIKPDNLLLDSKG--HVKLSDFGLCTGLKKAHRTE 163 Query: 212 EYKEDPKR----------------------------CHDGTIEFTSIDAHNGVAPSRRGD 243 Y+ GT ++ + + ++ D Sbjct: 164 FYRNLNHSLPSDFTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCD 223 Query: 244 LEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRY--------------RENIASLMDKC 289 LG M + L G+ P+ Y + + ++ I + Sbjct: 224 WWSLGVIMYEMLIGYPPFCSETPQETYKKVMNWKETLTFPPEVPISEKAKDLILRFCCEW 283 Query: 290 FPEKNKPGEIAKYMETVKLLDYTEKPLYENLR-DILLQGLKAIGSKDDGKLD 340 PG +E +K + E +E++R ++ D D Sbjct: 284 EHRIGAPG-----VEEIKSNSFFEGVDWEHIRERPAAISIEIKSIDDTSNFD 330 >3TKU-A nrPDB Length = 433 Score = 136 bits (343), Expect = 1e-32, Method: Composition-based stats. Identities = 46/266 (17%), Positives = 99/266 (37%), Gaps = 31/266 (11%) Query: 20 AEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGP 79 A+ F + ++++++ IG+G FG + + M ++E + + Sbjct: 75 AKPFTQLVKEMQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAM-------------K 121 Query: 80 LFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDR-FGSDL 138 + + + +RA + + R + G ++ + + +++ +++MD G DL Sbjct: 122 ILNKWEMLKRA----ETACFREERDVLVNGDCQWITALHYAFQDENHLYLVMDYYVGGDL 177 Query: 139 QKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDY 198 + + ++ ++ IH+ YVH DIK N+LL+ + L D+ Sbjct: 178 LTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNG--HIRLADF 235 Query: 199 GLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVA-----PSRRGDLEILGYCMIQ 253 G + +G + GT ++ S + + D LG CM + Sbjct: 236 GSCLKMNDDGTVQSS------VAVGTPDYISPEILQAMEDGMGKYGPECDWWSLGVCMYE 289 Query: 254 WLTGHLPWEDNLKDPKYVRDSKIRYR 279 L G P+ Y + R Sbjct: 290 MLYGETPFYAESLVETYGKIMNHEER 315 >3HKO-A nrPDB Length = 345 Score = 136 bits (343), Expect = 1e-32, Method: Composition-based stats. Identities = 56/334 (16%), Positives = 108/334 (32%), Gaps = 63/334 (18%) Query: 35 KEWKVGLPIGQGGFGCIYLADMNSSESVGS----DAPCVVKVEPSDNGPLFTELKFYQRA 90 K++ + IGQG +G + +A N + ++ + + + ++ P D + TE++ ++ Sbjct: 26 KKYHLKGAIGQGSYGVVRVAIENQTRAIRAIKIMNKNKIRQINPKDVERIKTEVRLMKKL 85 Query: 91 AKPE--QIQKWIRTRKLKYLGVPKYWGSGLHDK--------NGKSYRFMIM--------- 131 P ++ + + L + G L DK GK ++ Sbjct: 86 HHPNIARLYEVYEDEQYICLVMELCHGGHLLDKLNVFIDDSTGKCAMDVVKTQICPCPEC 145 Query: 132 --DRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKN 189 + + E+ K + + +I L Y+H H DIK N L + Sbjct: 146 NEEAINGSIHGFRESLDFVQREKLISNIMRQIFSALHYLHNQGICHRDIKPENFLFSTNK 205 Query: 190 PDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHN--GVAPSRRGDLEIL 247 ++ LVD+GL+ + + Y K GT F + + N + + D Sbjct: 206 SFEIKLVDFGLSKEFYKLNNGEYYGMTTK---AGTPYFVAPEVLNTTNESYGPKCDAWSA 262 Query: 248 GYCMIQWLTGHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVK 307 G + L G +P+ + + C Sbjct: 263 GVLLHLLLMGAVPFPGVNDADTISQVLNKK----------LC------------------ 294 Query: 308 LLDYTEKPLYENLRDILLQGLKA-IGSKDDGKLD 340 E P Y L + L + D + D Sbjct: 295 ----FENPNYNVLSPLARDLLSNLLNRNVDERFD 324 >5HI2-A nrPDB Length = 283 Score = 136 bits (343), Expect = 1e-32, Method: Composition-based stats. Identities = 48/301 (15%), Positives = 112/301 (37%), Gaps = 45/301 (14%) Query: 36 EWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQ 95 + VG IG G FG +Y + V + P E+ ++ Sbjct: 21 QITVGQRIGSGSFGTVYKGKWH-------GDVAVKMLTPQQLQAFKNEVGVLRKT----- 68 Query: 96 IQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYEANAKRFSRKTV 154 +++ + + G + K ++ GS L A+ +F K + Sbjct: 69 ----------RHVNILLFMGY-----STKPQLAIVTQWCEGSSLYHHLHASETKFEMKKL 113 Query: 155 LQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYK 214 + ++ + ++Y+H +H D+K++N+ L+ N V + D+GLA +++ Sbjct: 114 IDIARQTARGMDYLHAKSIIHRDLKSNNIFLHEDNT--VKIGDFGLATVKSRWSGSHQFE 171 Query: 215 EDPKRCHDGTIEFTSIDAH---NGVAPSRRGDLEILGYCMIQWLTGHLPWED-NLKDPKY 270 + G+I + + + + S + D+ G + + +TG LP+ + N +D Sbjct: 172 Q-----LSGSILWMAPEVIRMQDSNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQII 226 Query: 271 VRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDILLQGLKA 330 + +++ + C P + + M E+P + + + + + Sbjct: 227 EMVGRGSLSPDLSKVRSNC------PKRMKRLMAECLKKKRDERPSFPRILAEIEELARE 280 Query: 331 I 331 + Sbjct: 281 L 281 >4FR4-A nrPDB Length = 384 Score = 136 bits (343), Expect = 1e-32, Method: Composition-based stats. Identities = 44/243 (18%), Positives = 85/243 (34%), Gaps = 34/243 (13%) Query: 24 AVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVK--VEPSDNGPLF 81 V + D+ +++ IG+G FG + + N ++ + + + VE ++ +F Sbjct: 4 PVFDENEDVNFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVF 63 Query: 82 TELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKI 141 EL+ Q P + W + FM++D + Sbjct: 64 KELQIMQGLEHPFLVNLWYS-------------------FQDEEDMFMVVDLLLGGDLRY 104 Query: 142 YEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 + F +TV ++ L+Y+ +H D+K N+LL+ V++ D+ +A Sbjct: 105 HLQQNVHFKEETVKLFICELVMALDYLQNQRIIHRDMKPDNILLDEHG--HVHITDFNIA 162 Query: 202 YRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAH---NGVAPSRRGDLEILGYCMIQWLTGH 258 E GT + + + G S D LG + L G Sbjct: 163 AMLPRETQITTM--------AGTKPYMAPEMFSSRKGAGYSFAVDWWSLGVTAYELLRGR 214 Query: 259 LPW 261 P+ Sbjct: 215 RPY 217 >6E2O-A nrPDB Length = 295 Score = 136 bits (343), Expect = 1e-32, Method: Composition-based stats. Identities = 45/223 (20%), Positives = 93/223 (41%), Gaps = 31/223 (13%) Query: 43 IGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRT 102 +G+G +G +Y + + + +K P + R ++P ++ Sbjct: 30 LGKGTYGIVY-----AGRDLSNQVRIAIKEIPERD----------SRYSQPLH-EEIALH 73 Query: 103 RKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRF--SRKTVLQLSLR 160 + LK+ + +Y GS +NG FM G L + + + +T+ + + Sbjct: 74 KHLKHKNIVQYLGS--FSENGFIKIFMEQVP-GGSLSALLRSKWGPLKDNEQTIGFYTKQ 130 Query: 161 ILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRC 220 IL+ L+Y+H+++ VH DIK N+L+N + + D+G + R Sbjct: 131 ILEGLKYLHDNQIVHRDIKGDNVLINTY-SGVLKISDFGTSKRLAGI-------NPCTET 182 Query: 221 HDGTIEFTSIDAHNG--VAPSRRGDLEILGYCMIQWLTGHLPW 261 GT+++ + + + + D+ LG +I+ TG P+ Sbjct: 183 FTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPF 225 >3GUB-A nrPDB Length = 295 Score = 136 bits (342), Expect = 2e-32, Method: Composition-based stats. Identities = 41/252 (16%), Positives = 91/252 (36%), Gaps = 30/252 (11%) Query: 33 AKKEWKVGLPIGQGGFGCIYLADMN-SSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAA 91 + G +G G F + + + + + S G + Sbjct: 9 VDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRG-----------VS 57 Query: 92 KPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF--GSDLQKIYEANAKRF 149 + + ++ +++++ V LH+ +++ G +L A + Sbjct: 58 REDIEREVSILKEIQHPNVIT-----LHEVYENKTDVILIGELVAGGELFDFL-AEKESL 111 Query: 150 SRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKN--PDQVYLVDYGLAYRYCPE 207 + + + +IL+ + Y+H + H D+K N++L +N ++ ++D+GLA Sbjct: 112 TEEEATEFLKQILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLA------ 165 Query: 208 GVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKD 267 HK + + GT EF + + N D+ +G L+G P+ + K Sbjct: 166 --HKIDFGNEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQ 223 Query: 268 PKYVRDSKIRYR 279 S + Y Sbjct: 224 ETLANVSAVNYE 235 >4NIF-A nrPDB Length = 333 Score = 136 bits (342), Expect = 2e-32, Method: Composition-based stats. Identities = 39/248 (15%), Positives = 75/248 (30%), Gaps = 32/248 (12%) Query: 32 MAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAA 91 + + V IG G + ++ VKV E++ R Sbjct: 5 VFSDGYVVKETIGVGSYSECKRCVHK-----ATNMEYAVKVIDKSKRDPSEEIEILLRYG 59 Query: 92 KPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSR 151 + + + + + +++ + K FS Sbjct: 60 Q--------------HPNIITLKDVY----DDGKHVYLVTELMRGGELLDKILRQKFFSE 101 Query: 152 KTVLQLSLRILDILEYIHEHEYVHGDIKASNLLL--NYKNPDQVYLVDYGLAYRYCPEGV 209 + + I +EY+H VH D+K SN+L NP+ + + D+G A + E Sbjct: 102 REASFVLHTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAE-- 159 Query: 210 HKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPK 269 T F + + D+ LG + L G+ P+ + D Sbjct: 160 -----NGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTP 214 Query: 270 YVRDSKIR 277 ++I Sbjct: 215 EEILTRIG 222 >2H8H-A nrPDB Length = 535 Score = 136 bits (341), Expect = 2e-32, Method: Composition-based stats. Identities = 46/293 (15%), Positives = 107/293 (36%), Gaps = 44/293 (15%) Query: 38 KVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQ 97 ++ + +GQG FG +++ N + V + P E + ++ + +Q Sbjct: 270 RLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSP---EAFLQEAQVMKKLRHEKLVQ 326 Query: 98 KWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF--GSDLQKIYEANAKRFSRKTVL 155 L+ + +++ + GS L + K ++ Sbjct: 327 --------------------LYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLV 366 Query: 156 QLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKE 215 ++ +I + Y+ YVH D++A+N+L+ + D+GLA ++ + Sbjct: 367 DMAAQIASGMAYVERMNYVHRDLRAANILVGENLVC--KVADFGLARLI------EDNEY 418 Query: 216 DPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT-GHLPWEDNLKDPKYVRDS 274 ++ I++T+ +A + + D+ G + + T G +P+ + + + + Sbjct: 419 TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPY-PGMVNREVLDQV 477 Query: 275 KIRYRENIASLM------DKCFPEKNKPGEIAKYMETVKLL-DYT--EKPLYE 318 + YR C + +P E + L DY +P Y+ Sbjct: 478 ERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQ 530 >3TAC-A nrPDB Length = 361 Score = 135 bits (340), Expect = 3e-32, Method: Composition-based stats. Identities = 48/267 (17%), Positives = 93/267 (34%), Gaps = 32/267 (11%) Query: 24 AVGEIITDMAK--KEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPL 80 G + D +++ IG+G F + + + + V K S Sbjct: 13 PRGSMADDDVLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPG--- 69 Query: 81 FTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDL- 138 + + ++ LK+ + + + D +M+ + G+DL Sbjct: 70 ---------LSTEDLKREASICHMLKHPHIVELLETYSSDGM----LYMVFEFMDGADLC 116 Query: 139 QKIYEANAKRF--SRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQ-VYL 195 +I + F S +IL+ L Y H++ +H D+K +LL K V L Sbjct: 117 FEIVKRADAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKL 176 Query: 196 VDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWL 255 +G+A + G+ GT F + + + D+ G + L Sbjct: 177 GGFGVAIQLGESGLV-------AGGRVGTPHFMAPEVVKREPYGKPVDVWGCGVILFILL 229 Query: 256 TGHLPWEDNLKDPKYVRDSKIRYRENI 282 +G LP+ K+ + K +Y+ N Sbjct: 230 SGCLPFYG-TKERLFEGIIKGKYKMNP 255 >6F3F-A nrPDB Length = 455 Score = 135 bits (340), Expect = 3e-32, Method: Composition-based stats. Identities = 47/293 (16%), Positives = 107/293 (36%), Gaps = 44/293 (15%) Query: 38 KVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQ 97 ++ + +GQG FG +++ N + V + P E + ++ + +Q Sbjct: 190 RLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSP---EAFLQEAQVMKKLRHEKLVQ 246 Query: 98 KWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF--GSDLQKIYEANAKRFSRKTVL 155 L+ + +++ + GS L + K ++ Sbjct: 247 --------------------LYAVVSEEPIYIVTEYMNKGSLLDFLKGETGKYLRLPQLV 286 Query: 156 QLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKE 215 +S +I + Y+ YVH D++A+N+L+ + D+GLA ++ + Sbjct: 287 DMSAQIASGMAYVERMNYVHRDLRAANILVGENLVC--KVADFGLARLI------EDNEY 338 Query: 216 DPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT-GHLPWEDNLKDPKYVRDS 274 ++ I++T+ +A + + D+ G + + T G +P+ + + + + Sbjct: 339 TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPY-PGMVNREVLDQV 397 Query: 275 KIRYRENIASLM------DKCFPEKNKPGEIAKYMETVKLL-DYT--EKPLYE 318 + YR C + +P E + L DY +P Y+ Sbjct: 398 ERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQ 450 >2BPM-A nrPDB Length = 309 Score = 135 bits (339), Expect = 3e-32, Method: Composition-based stats. Identities = 51/305 (16%), Positives = 111/305 (36%), Gaps = 38/305 (12%) Query: 30 TDMAKKEWKVGLPIGQGGFGCIYLADMN-SSESVGSDAPCVVKVEPSDNGPLFTELKFYQ 88 + + ++ IG+G +G +Y A + E V ++++ G Sbjct: 2 PLVDMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKK---IRLDTETEGV--------- 49 Query: 89 RAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKR 148 I++ ++L + + K + + +++ + DL+K +A+A Sbjct: 50 ---PSTAIREISLLKELNHPNIVKLLDVIHTE----NKLYLVFEFLHQDLKKFMDASALT 102 Query: 149 -FSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPE 207 + ++L L + H H +H D+K NLL+N + + L D+GLA + Sbjct: 103 GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEG--AIKLADFGLARAFG-- 158 Query: 208 GVHKEYKEDPKRCHDGTIEFTSIDAHNG-VAPSRRGDLEILGYCMIQWLTGHLPWEDNLK 266 + T+ + + + G S D+ LG + +T + + + Sbjct: 159 ---VPVRTYTHEVV--TLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSE 213 Query: 267 DPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTE--KPLYENLRDIL 324 + R +R + P + + + D+++ PL E+ R +L Sbjct: 214 IDQLFRI----FRTLGTPDEVVWPGVTSMPDYKPSFPKWARQ-DFSKVVPPLDEDGRSLL 268 Query: 325 LQGLK 329 Q L Sbjct: 269 SQMLH 273 >3FXW-A nrPDB Length = 336 Score = 134 bits (337), Expect = 5e-32, Method: Composition-based stats. Identities = 42/237 (17%), Positives = 76/237 (32%), Gaps = 33/237 (13%) Query: 33 AKKEWKVGLP-IGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAA 91 ++++ +G G G + + C +K+ L+ K Q Sbjct: 26 VTDDYQLSKQVLGLGVNGKVLECFHR-----RTGQKCALKL-------LYDSPKARQEVD 73 Query: 92 KPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF--GSDLQKIYEANAKRF 149 Q + + +GK +IM+ G +I E + F Sbjct: 74 HHWQASGG--------PHIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAF 125 Query: 150 SRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQV-YLVDYGLAYRYCPEG 208 + + ++ I ++++H H H D+K NLL K D V L D+G A Sbjct: 126 TEREAAEIMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNA 185 Query: 209 VHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNL 265 + T + + + + D+ LG M L G P+ N Sbjct: 186 LQTP---------CYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGFPPFYSNT 233 >5B2L-A nrPDB Length = 324 Score = 134 bits (337), Expect = 5e-32, Method: Composition-based stats. Identities = 44/285 (15%), Positives = 108/285 (37%), Gaps = 41/285 (14%) Query: 42 PIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIR 101 +G G G ++ + V + +N + +L Sbjct: 24 EMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVV-------------- 69 Query: 102 TRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRI 161 + + + +G+ + + + F+ M+ G+ +K+ + + + ++++ I Sbjct: 70 LKSHDCPYIVQCFGTFITNTD----VFIAMELMGTSAEKLKKRMQGPIPERILGKMTVAI 125 Query: 162 LDILEYIHE-HEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRC 220 + L Y+ E H +H D+K SN+LL+ + Q+ L D+G++ R Sbjct: 126 VKALYYLKEKHGVIHRDVKPSNILLDERG--QIKLCDFGISGRLVDSKAKTR-------- 175 Query: 221 HDGTIEFTSIDAHNGVAPSR-----RGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSK 275 G + + + + P++ R D+ LG +++ TG P+++ D + + Sbjct: 176 SAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVL---- 231 Query: 276 IRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENL 320 + + L+ G+ +++ D+ ++P Y L Sbjct: 232 TKVLQEEPPLL---PGHMGFSGDFQSFVKDCLTKDHRKRPKYNKL 273 >3A4O-X nrPDB Length = 286 Score = 134 bits (337), Expect = 6e-32, Method: Composition-based stats. Identities = 48/292 (16%), Positives = 109/292 (37%), Gaps = 43/292 (14%) Query: 38 KVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQ 97 K+ +G G FG +++ N+S V + F + A Sbjct: 16 KLVKRLGAGQFGEVWMGYYNNSTKVAVKTL---------KPGTMSVQAFLEEAN------ 60 Query: 98 KWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF--GSDLQKIYEANAKRFSRKTVL 155 + L++ + + + ++ ++I + GS L + + ++ Sbjct: 61 ---LMKTLQHDKLVRLYAVVTREEP----IYIITEYMAKGSLLDFLKSDEGGKVLLPKLI 113 Query: 156 QLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKE 215 S +I + + YI Y+H D++A+N+L++ + D+GLA ++ + Sbjct: 114 DFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMC--KIADFGLARVI------EDNEY 165 Query: 216 DPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT-GHLPWEDNLKDPKYVRDS 274 + I++T+ +A N + + D+ G + + +T G +P+ + + Sbjct: 166 TAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPY-PGRTNADVMTAL 224 Query: 275 KIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDILLQ 326 YR +N P E+ M+ E+P ++ L+ +L Sbjct: 225 SQGYRMPRV---------ENCPDELYDIMKMCWKEKAEERPTFDYLQSVLDD 267 >4EBW-A nrPDB Length = 304 Score = 134 bits (336), Expect = 7e-32, Method: Composition-based stats. Identities = 55/300 (18%), Positives = 108/300 (36%), Gaps = 38/300 (12%) Query: 22 QFAVGEIITDMAKKEWKV--GLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGP 79 Q A+G D + ++ G IG+G FG ++ S E+ +K + Sbjct: 23 QGAMGSSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPA--LAVAIKTCKNCTSD 80 Query: 80 LFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFG-SDL 138 E +Q+ + R+ + + K G + ++IM+ +L Sbjct: 81 SVREKF----------LQEALTMRQFDHPHIVKLIGVITENP-----VWIIMELCTLGEL 125 Query: 139 QKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDY 198 + + +++ + ++ L Y+ +VH DI A N+L++ + V L D+ Sbjct: 126 RSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDC--VKLGDF 183 Query: 199 GLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT-G 257 GL+ +K K I++ + ++ N + D+ + G CM + L G Sbjct: 184 GLSRYMEDSTYYKASKGKL------PIKWMAPESINFRRFTSASDVWMFGVCMWEILMHG 237 Query: 258 HLPWEDNLKDPKYVRDSKIRYRENI-------ASLMDKCFPEKNKPGEIAKYMETVKLLD 310 P++ + R SLM KC+ P ++ E L Sbjct: 238 VKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYD--PSRRPRFTELKAQLS 295 >2HW6-A nrPDB Length = 307 Score = 134 bits (336), Expect = 7e-32, Method: Composition-based stats. Identities = 31/245 (12%), Positives = 77/245 (31%), Gaps = 28/245 (11%) Query: 29 ITDMAKKEWKV-GLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKF 86 + + +K+ +G+G + + A + + + K +F E++ Sbjct: 6 LPGKFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIE--KQAGHSRSRVFREVET 63 Query: 87 YQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANA 146 + + I + I + +++ ++ + Sbjct: 64 LYQCQGNKNILELIEF------------------FEDDTRFYLVFEKLQGGSILAHIQKQ 105 Query: 147 KRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNP-DQVYLVDYGLAYRYC 205 K F+ + ++ + L+++H H D+K N+L V + D+ L Sbjct: 106 KHFNEREASRVVRDVAAALDFLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMK 165 Query: 206 PEGVHKEYKEDPKRCHDGTIEFTSIDAHN-----GVAPSRRGDLEILGYCMIQWLTGHLP 260 G+ E+ + + +R DL LG + L+G+ P Sbjct: 166 LNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPP 225 Query: 261 WEDNL 265 + + Sbjct: 226 FVGHC 230 >3CJF-A nrPDB Length = 309 Score = 134 bits (336), Expect = 8e-32, Method: Composition-based stats. Identities = 53/315 (16%), Positives = 110/315 (34%), Gaps = 40/315 (12%) Query: 15 AKRHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEP 74 E+ + + +G P+G+G FG + AD + + VK+ Sbjct: 7 PLDEHCERLPYDASKWEFPRDRLNLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLK 66 Query: 75 SDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF 134 G +E + K I +L V G+ K G ++ Sbjct: 67 --EGATHSEHRALMSELK-------ILIHIGHHLNVVNLLGA--CTKPGGPLMVIVEFCK 115 Query: 135 GSDLQKIYEANAKRF-----------SRKTVLQLSLRILDILEYIHEHEYVHGDIKASNL 183 +L + F + + ++ S ++ +E++ + +H D+ A N+ Sbjct: 116 FGNLSTYLRSKRNEFVPYKDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNI 175 Query: 184 LLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGD 243 LL+ KN V + D+GLA ++K+ K +++ + + + + D Sbjct: 176 LLSEKN--VVKICDFGLAR-----DIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSD 228 Query: 244 LEILGYCMIQWLT-GHLPWEDNLKDPKYVRDSKIRYR--------ENIASLMDKCFPEKN 294 + G + + + G P+ D ++ R K R + M C+ Sbjct: 229 VWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWH--G 286 Query: 295 KPGEIAKYMETVKLL 309 +P + + E V+ L Sbjct: 287 EPSQRPTFSELVEHL 301 >2DQ7-X nrPDB Length = 283 Score = 134 bits (336), Expect = 8e-32, Method: Composition-based stats. Identities = 43/291 (14%), Positives = 108/291 (37%), Gaps = 44/291 (15%) Query: 41 LPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWI 100 +G G FG +++ N + V + P E + ++ + +Q Sbjct: 15 KRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSP---ESFLEEAQIMKKLKHDKLVQ--- 68 Query: 101 RTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF--GSDLQKIYEANAKRFSRKTVLQLS 158 L+ + +++ + GS L + + + ++ ++ Sbjct: 69 -----------------LYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMA 111 Query: 159 LRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPK 218 ++ + YI Y+H D++++N+L+ + D+GLA ++ + + Sbjct: 112 AQVAAGMAYIERMNYIHRDLRSANILVGNGLIC--KIADFGLARLI------EDNEYTAR 163 Query: 219 RCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT-GHLPWEDNLKDPKYVRDSKIR 277 + I++T+ +A + + D+ G + + +T G +P+ + + + + + Sbjct: 164 QGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPY-PGMNNREVLEQVERG 222 Query: 278 YRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDILLQGL 328 YR C ++ P + + M D E+P +E L+ L Sbjct: 223 YR-------MPC--PQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYF 264 >3KA0-A nrPDB Length = 320 Score = 133 bits (335), Expect = 9e-32, Method: Composition-based stats. Identities = 32/187 (17%), Positives = 67/187 (35%), Gaps = 13/187 (6%) Query: 83 ELKFYQRAAKPEQIQKWIRT--RKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF--GSDL 138 E + + ++ + R + + + + G+ ++M+ G Sbjct: 42 EKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELF 101 Query: 139 QKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQV-YLVD 197 +I + + F+ + ++ I + ++Y+H H D+K NLL K P+ + L D Sbjct: 102 SRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTD 161 Query: 198 YGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTG 257 +G A E T + + + + D+ LG M L G Sbjct: 162 FGFAKETTSHNSLTEPCY--------TPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCG 213 Query: 258 HLPWEDN 264 + P+ N Sbjct: 214 YPPFYSN 220 >3DTC-A nrPDB Length = 271 Score = 133 bits (334), Expect = 1e-31, Method: Composition-based stats. Identities = 58/293 (19%), Positives = 104/293 (35%), Gaps = 48/293 (16%) Query: 43 IGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRT 102 IG GGFG +Y A VK D ++ Q+ Sbjct: 15 IGIGGFGKVYRA-------FWIGDEVAVKAARHDPDEDISQ-------TIENVRQEAKLF 60 Query: 103 RKLKYLGVPKYWGSGLHDKNGKSYRFMIMDR-FGSDLQKIYEANAKRFSRKTVLQLSLRI 161 LK+ + G L + ++M+ G L ++ + KR ++ +++I Sbjct: 61 AMLKHPNIIALRGVCLKE----PNLCLVMEFARGGPLNRVL--SGKRIPPDILVNWAVQI 114 Query: 162 LDILEYIHEHEY---VHGDIKASNLLLNYK------NPDQVYLVDYGLAYRYCPEGVHKE 212 + Y+H+ +H D+K+SN+L+ K + + + D+GLA E Sbjct: 115 ARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAR---------E 165 Query: 213 YKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVR 272 + K G + + + S+ D+ G + + LTG +P+ D V Sbjct: 166 WHRTTKMSAAGAYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGI--DGLAVA 223 Query: 273 DSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDILL 325 + + + C P AK ME D +P + N+ D L Sbjct: 224 YG-VAMNKLALPIPSTC------PEPFAKLMEDCWNPDPHSRPSFTNILDQLT 269 >1NY3-A nrPDB Length = 400 Score = 133 bits (333), Expect = 2e-31, Method: Composition-based stats. Identities = 31/187 (16%), Positives = 66/187 (35%), Gaps = 13/187 (6%) Query: 83 ELKFYQRAAKPEQIQKWIRT--RKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF--GSDL 138 E + + ++ + R + + + + G+ ++M+ G Sbjct: 88 EKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELF 147 Query: 139 QKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQV-YLVD 197 +I + + F+ + ++ I + ++Y+H H D+K NLL K P+ + L D Sbjct: 148 SRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTD 207 Query: 198 YGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTG 257 +G A T + + + + D+ LG M L G Sbjct: 208 FGFAKETTSHNSLTTPCY--------TPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCG 259 Query: 258 HLPWEDN 264 + P+ N Sbjct: 260 YPPFYSN 266 >5SYS-A nrPDB Length = 286 Score = 133 bits (333), Expect = 2e-31, Method: Composition-based stats. Identities = 48/314 (15%), Positives = 114/314 (36%), Gaps = 45/314 (14%) Query: 17 RHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSD 76 H+ Q + + ++ ++ ++ + +GQG FG ++ N + V + P Sbjct: 1 GHMQTQG-LAKDAWEIPRESLRLEVKLGQGCFGECWMGTWNGTTRVAIKTLKPGTMSP-- 57 Query: 77 NGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-- 134 E + ++ + +Q L+ + +++ + Sbjct: 58 -EAFLQEAQVMKKLRHEKLVQ--------------------LYAVVSEEPIYIVTEYMSK 96 Query: 135 GSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVY 194 GS L + K ++ ++ +I + Y+ YVH D++A+N+L+ Sbjct: 97 GSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVC--K 154 Query: 195 LVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQW 254 + D+GLA ++ + ++ I++T+ +A + + D+ G + + Sbjct: 155 VADFGLARLI------EDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTEL 208 Query: 255 LT-GHLPWEDNLKDPKYVRDSKIRYRENIASLM------DKCFPEKNKPGEIAKYMETVK 307 T G +P+ + + + + + YR C + P E + Sbjct: 209 TTKGRVPY-PGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKDPEERPTFEYLQA 267 Query: 308 LL-DYT--EKPLYE 318 L DY +P Y+ Sbjct: 268 FLEDYFTSTEPQYQ 281 >2OZA-A nrPDB Length = 356 Score = 132 bits (332), Expect = 2e-31, Method: Composition-based stats. Identities = 31/187 (16%), Positives = 66/187 (35%), Gaps = 13/187 (6%) Query: 83 ELKFYQRAAKPEQIQKWIRT--RKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF--GSDL 138 E + + ++ + R + + + + G+ ++M+ G Sbjct: 44 EKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELF 103 Query: 139 QKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQV-YLVD 197 +I + + F+ + ++ I + ++Y+H H D+K NLL K P+ + L D Sbjct: 104 SRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTD 163 Query: 198 YGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTG 257 +G A T + + + + D+ LG M L G Sbjct: 164 FGFAKETTSHNSLTTPCY--------TPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCG 215 Query: 258 HLPWEDN 264 + P+ N Sbjct: 216 YPPFYSN 222 >6CQF-A nrPDB Length = 297 Score = 132 bits (332), Expect = 2e-31, Method: Composition-based stats. Identities = 43/230 (18%), Positives = 86/230 (37%), Gaps = 34/230 (14%) Query: 35 KEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPE 94 + + +G G +G ++ A S + + VK+EP D+ Sbjct: 16 DHYDLLQRLGGGTYGEVFKARDKVSGDLVALKM--VKMEPDDDVSTLQ------------ 61 Query: 95 QIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFG-SDLQKIYEANAKRFSRKT 153 ++ + + ++ + Y GS L ++ M+ G LQ IY+ S Sbjct: 62 --KEILILKTCRHANIVAYHGSYL----WLQKLWICMEFCGAGSLQDIYQVTGS-LSELQ 114 Query: 154 VLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEY 213 + + +L L Y+H + +H DIK +N+L+N + +V L D+G++ + Sbjct: 115 ISYVCREVLQGLAYLHSQKKIHRDIKGANILIN--DAGEVRLADFGISAQIGATL----- 167 Query: 214 KEDPKRCHDGTIEFTSID---AHNGVAPSRRGDLEILGYCMIQWLTGHLP 260 + GT + + + + D+ LG I+ P Sbjct: 168 --ARRLAFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQPP 215 >2J0K-A nrPDB Length = 656 Score = 132 bits (332), Expect = 2e-31, Method: Composition-based stats. Identities = 51/300 (17%), Positives = 106/300 (35%), Gaps = 36/300 (12%) Query: 20 AEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGP 79 ++ ++ ++G IG+G FG ++ S E+ +K + Sbjct: 375 DTYTMPSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPA--MAVAIKTCKNCTSD 432 Query: 80 LFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFG-SDL 138 E +Q+ + R+ + + K G + ++IM+ +L Sbjct: 433 SVREKF----------LQEALTMRQFDHPHIVKLIGVITENP-----VWIIMELCTLGEL 477 Query: 139 QKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDY 198 + + +++ + ++ L Y+ +VH DI A N+L++ + V L D+ Sbjct: 478 RSFLQVRKFSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSATDC--VKLGDF 535 Query: 199 GLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT-G 257 GL+ +K K I++ + ++ N + D+ + G CM + L G Sbjct: 536 GLSRYMEDSTYYKASKGKL------PIKWMAPESINFRRFTSASDVWMFGVCMWEILMHG 589 Query: 258 HLPWEDNLKDPKYVRDSKIRYRENI-------ASLMDKCFPEKNKPGEIAKYMETVKLLD 310 P++ + R SLM KC+ P ++ E L Sbjct: 590 VKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYD--PSRRPRFTELKAQLS 647 >5DYK-A nrPDB Length = 853 Score = 132 bits (331), Expect = 3e-31, Method: Composition-based stats. Identities = 44/256 (17%), Positives = 92/256 (35%), Gaps = 33/256 (12%) Query: 17 RHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSD 76 HL E+ + + +M E + IG+G FG + L ++ +K Sbjct: 523 AHLEERIKMQDTKVEM--DELETERIIGRGTFGTVKLVHHKPTKI-----RYALKCVSKR 575 Query: 77 NGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-G 135 + + + + T + + + + + Y + + + G Sbjct: 576 SIINLNQQNNIKLERE--------ITAENDHPFIIRLVRT----FKDSKYFYFLTELVTG 623 Query: 136 SDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYL 195 +L S+ I+ +EY+HE V+ D+K N+LL+ V L Sbjct: 624 GELYDAI-RKLGLLSKSQAQFYLGSIILAIEYLHERNIVYRDLKPENILLD--KQGYVKL 680 Query: 196 VDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWL 255 +D+G A + + GT + + + G D+ LG C+ +++ Sbjct: 681 IDFGCAKKV----------QGRAYTLVGTPHYMAPEVILGKGYGCTVDIWALGICLYEFI 730 Query: 256 TGHLPWEDNLKDPKYV 271 G LP+ ++ +D + Sbjct: 731 CGPLPFGNDEEDQLEI 746 >6HXF-B nrPDB Length = 302 Score = 132 bits (331), Expect = 3e-31, Method: Composition-based stats. Identities = 39/285 (13%), Positives = 97/285 (34%), Gaps = 43/285 (15%) Query: 37 WKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQI 96 W++ +G G FG +Y A + ++ + K E + I Sbjct: 21 WEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSE----------------EELEDYI 64 Query: 97 QKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYEANAKRFSRKTVL 155 + + + K G+ HD +++++ G + I + + + Sbjct: 65 VEIEILATCDHPYIVKLLGAYYHD----GKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQ 120 Query: 156 QLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKE 215 + ++L+ L ++H +H D+KA N+L+ + + L D+G++ + ++ Sbjct: 121 VVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEG--DIRLADFGVSAKNLKTLQKRD--- 175 Query: 216 DPKRCHDGTIEFTSIDAHNGV-----APSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKY 270 GT + + + + D+ LG +I+ P + Sbjct: 176 ----SFIGTPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVL 231 Query: 271 VRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKP 315 ++ +K + L + E +++ + +P Sbjct: 232 LKIAK---SDPPTLLTPSKW-----SVEFRDFLKIALDKNPETRP 268 >4AU8-A nrPDB Length = 296 Score = 132 bits (331), Expect = 3e-31, Method: Composition-based stats. Identities = 49/271 (18%), Positives = 95/271 (35%), Gaps = 33/271 (12%) Query: 31 DMAKKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQR 89 M ++++ IG+G +G ++ A + + E V V+++ D G Sbjct: 2 AMGSQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKR---VRLDDDDEGV---------- 48 Query: 90 AAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRF 149 +++ ++LK+ + + DK ++ + DL+K +++ Sbjct: 49 --PSSALREICLLKELKHKNIVRLHDVLHSDKK----LTLVFEFCDQDLKKYFDSCNGDL 102 Query: 150 SRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGV 209 + V ++L L + H +H D+K NLL+N ++ L D+GLA + Sbjct: 103 DPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNG--ELKLADFGLARAFG---- 156 Query: 210 HKEYKEDPKRCHDGTIEFTSIDAHNG-VAPSRRGDLEILGYCMIQWLT-GHLPWEDNLKD 267 T+ + D G S D+ G + G + N D Sbjct: 157 ---IPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVD 213 Query: 268 PKYVRDSK--IRYRENIASLMDKCFPEKNKP 296 + R + E M K K P Sbjct: 214 DQLKRIFRLLGTPTEEQWPSMTKLPDYKPYP 244 >3VN9-A nrPDB Length = 340 Score = 131 bits (330), Expect = 4e-31, Method: Composition-based stats. Identities = 57/344 (16%), Positives = 119/344 (34%), Gaps = 47/344 (13%) Query: 1 MPRVKAAQAGRQSSAKRHLAEQFAV--GEIITDMAKKEWKVGLPIGQGGFGCIYLADMNS 58 +P+ Q S+ R L + + G ++ + + + +G+G +G + Sbjct: 15 IPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVP 74 Query: 59 SESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGL 118 S + + V + L +L I R + ++G+ Sbjct: 75 SGQIMAVKRIRATVNSQEQKRLLMDL--------------DISMRTVDCPFTVTFYGALF 120 Query: 119 HDKNGKSYRFMIMDRFGSDLQKIYE---ANAKRFSRKTVLQLSLRILDILEYIHEH-EYV 174 + + ++ M+ + L K Y+ + + ++++ I+ LE++H + Sbjct: 121 REGD----VWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVI 176 Query: 175 HGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHN 234 H D+K SN+L+N QV + D+G++ K G + + + N Sbjct: 177 HRDVKPSNVLINA--LGQVKMCDFGISGYLVDSV--------AKTIDAGCKPYMAPERIN 226 Query: 235 G----VAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCF 290 S + D+ LG MI+ P+ D+ P K E L Sbjct: 227 PELNQKGYSVKSDIWSLGITMIELAILRFPY-DSWGTPFQQ--LKQVVEEPSPQL----- 278 Query: 291 PEKNKPGEIAKYMETVKLLDYTEKPLY-ENLRDILLQGLKAIGS 333 P E + + E+P Y E ++ ++ G+ Sbjct: 279 PADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGT 322 >2Y7J-A nrPDB Length = 365 Score = 131 bits (329), Expect = 6e-31, Method: Composition-based stats. Identities = 42/266 (15%), Positives = 84/266 (31%), Gaps = 32/266 (12%) Query: 2 PRVKAAQAGRQSSAKRHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSES 61 P+ + + L + A E +++ IG+G + Sbjct: 66 PKGTENLYFQSMGPEDELPDWAAAKE-----FYQKYDPKDVIGRGVSSVVRRCVHR---- 116 Query: 62 VGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDK 121 + VK+ L E + + + + I + + + S Sbjct: 117 -ATGHEFAVKIMEVTAERLSPEQ--LEEVREATRRETHILRQVAGHPHIITLIDSY---- 169 Query: 122 NGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKAS 181 S+ F++ D Y S K + +L+ + ++H + VH D+K Sbjct: 170 ESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLEAVSFLHANNIVHRDLKPE 229 Query: 182 NLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNG------ 235 N+LL+ + Q+ L D+G + P +E GT + + + Sbjct: 230 NILLD--DNMQIRLSDFGFSCHLEPGEKLRE--------LCGTPGYLAPEILKCSMDETH 279 Query: 236 VAPSRRGDLEILGYCMIQWLTGHLPW 261 + DL G + L G P+ Sbjct: 280 PGYGKEVDLWACGVILFTLLAGSPPF 305 >5D7A-A nrPDB Length = 308 Score = 131 bits (328), Expect = 7e-31, Method: Composition-based stats. Identities = 48/295 (16%), Positives = 108/295 (36%), Gaps = 43/295 (14%) Query: 37 WKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQI 96 +++ +G G +G +Y + + + V+ V + + E+ ++ + Sbjct: 19 FELVELVGNGTYGQVYKGRHVKTGQLAAIK--VMDVTGDEEEEIKQEINMLKKYSH---- 72 Query: 97 QKWIRTRKLKYLGVPKYWGSGLHDKNG--KSYRFMIMDRFG-SDLQKIY-EANAKRFSRK 152 + + Y+G+ + +++M+ G + + + Sbjct: 73 ----------HRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEE 122 Query: 153 TVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKE 212 + + IL L ++H+H+ +H DIK N+LL +V LVD+G++ + Sbjct: 123 WIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTEN--AEVKLVDFGVSAQLDRTV---- 176 Query: 213 YKEDPKRCHDGTIEFTSIDAHNGVA-----PSRRGDLEILGYCMIQWLTGHLPWEDNLKD 267 + GT + + + + DL LG I+ G P L D Sbjct: 177 ---GRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPP----LCD 229 Query: 268 PKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRD 322 +R + R L K + +K ++E+ + +++++P E L Sbjct: 230 MHPMRALFLIPRNPAPRLKSKKWSKK-----FQSFIESCLVKNHSQRPATEQLMK 279 >2VD5-A nrPDB Length = 412 Score = 131 bits (328), Expect = 7e-31, Method: Composition-based stats. Identities = 56/351 (15%), Positives = 116/351 (33%), Gaps = 64/351 (18%) Query: 20 AEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGP 79 AE V + + ++++ IG+G F + + M + V + Sbjct: 46 AEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAM-------------K 92 Query: 80 LFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDR-FGSDL 138 + + +R ++ + R + G ++ ++Y +++M+ G DL Sbjct: 93 IMNKWDMLKR----GEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDL 148 Query: 139 QKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDY 198 + +R + I+ ++ +H YVH DIK N+LL+ + L D+ Sbjct: 149 LTLLSKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLD--RCGHIRLADF 206 Query: 199 GLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSR-------RGDLEILGYCM 251 G + +G + GT ++ S + V D LG Sbjct: 207 GSCLKLRADGTVRS------LVAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFA 260 Query: 252 IQWLTGHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLL-- 309 + G P+ + Y + + ++ + ++ P E + +LL Sbjct: 261 YEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLV------DEGVPEEARDF--IQRLLCP 312 Query: 310 -----------DYTEKP-----LYENLRDI---LLQGLKAIGSKDDGKLDL 341 D+ P ++ LRD + G+ D DL Sbjct: 313 PETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPDFE--GATDTCNFDL 361 >5HIE-A nrPDB Length = 302 Score = 131 bits (328), Expect = 7e-31, Method: Composition-based stats. Identities = 46/287 (16%), Positives = 104/287 (36%), Gaps = 45/287 (15%) Query: 36 EWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQ 95 + VG IG G FG +Y + V + P E+ ++ Sbjct: 37 QITVGQRIGSGSFGTVYKGKWH-------GDVAVKMLTPQQLQAFKNEVGVLRKT----- 84 Query: 96 IQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYEANAKRFSRKTV 154 +++ + + G + K ++ GS L +F + Sbjct: 85 ----------RHVNILLFMGY-----STKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKL 129 Query: 155 LQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYK 214 + ++ + ++Y+H +H D+K++N+ L+ V + D+GLA +++ Sbjct: 130 IDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLT--VKIGDFGLATVKSRWSGSHQFE 187 Query: 215 EDPKRCHDGTIEFTSIDAH---NGVAPSRRGDLEILGYCMIQWLTGHLPWED-NLKDPKY 270 + G+I + + + + S + D+ G + + +TG LP+ + N +D Sbjct: 188 Q-----LSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQII 242 Query: 271 VRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLY 317 + +++ + C P + + M E+PL+ Sbjct: 243 FMVGRGYLSPDLSKVRSNC------PKAMKRLMAECLKKKRDERPLF 283 >2UV2-A nrPDB Length = 325 Score = 131 bits (328), Expect = 7e-31, Method: Composition-based stats. Identities = 31/232 (13%), Positives = 76/232 (32%), Gaps = 35/232 (15%) Query: 35 KEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPE 94 W++ +G G FG +Y A + + + K E + Sbjct: 37 DFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMV------------- 83 Query: 95 QIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEAN-AKRFSRKT 153 + + + K + ++ + +++++ + + Sbjct: 84 ---EIDILASCDHPNIVKLLDAFYYE----NNLWILIEFCAGGAVDAVMLELERPLTESQ 136 Query: 154 VLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEY 213 + + + LD L Y+H+++ +H D+KA N+L + L D+G++ + Sbjct: 137 IQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDG--DIKLADFGVSAKNTRTIQ---- 190 Query: 214 KEDPKRCHDGTIEFTSIDAHNG-----VAPSRRGDLEILGYCMIQWLTGHLP 260 + GT + + + + D+ LG +I+ P Sbjct: 191 ---RRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPP 239 >2I6L-A nrPDB Length = 320 Score = 130 bits (327), Expect = 8e-31, Method: Composition-based stats. Identities = 46/248 (18%), Positives = 90/248 (36%), Gaps = 24/248 (9%) Query: 34 KKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAK 92 + P+G GG G ++ A D + + V +V +P E+K +R Sbjct: 10 GSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKK--IVLTDPQSVKHALREIKIIRRLDH 67 Query: 93 PEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGK----SYRFMIMDRFGSDLQKIYEANAKR 148 ++ + + GS L D G + +++ + +DL + E Sbjct: 68 DNIVKVFE---------ILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLE--QGP 116 Query: 149 FSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEG 208 + ++L L+YIH +H D+K +NL +N ++ + + D+GLA P Sbjct: 117 LLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTED-LVLKIGDFGLARIMDPHY 175 Query: 209 VHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRG-DLEILGYCMIQWLTGHLPWEDNLKD 267 HK + + T + S + D+ G + LTG + + Sbjct: 176 SHKGHLSEGLV----TKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHEL 231 Query: 268 PKYVRDSK 275 + + Sbjct: 232 EQMQLILE 239 >1TKI-A nrPDB Length = 321 Score = 130 bits (327), Expect = 9e-31, Method: Composition-based stats. Identities = 40/252 (15%), Positives = 95/252 (37%), Gaps = 32/252 (12%) Query: 35 KEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPE 94 +++ + +G+G FG ++ SS+ VKV+ +D + E+ A Sbjct: 5 EKYMIAEDLGRGEFGIVHRCVETSSKKTYMAKF--VKVKGTDQVLVKKEISILNIARHRN 62 Query: 95 QIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYEANAKRFSRKT 153 + ++ L MI + G D+ + +A + + Sbjct: 63 ILHLHESFESMEEL-------------------VMIFEFISGLDIFERINTSAFELNERE 103 Query: 154 VLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEY 213 ++ ++ + L+++H H H DI+ N++ + + ++++G A + P + Sbjct: 104 IVSYVHQVCEALQFLHSHNIGHFDIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLL 163 Query: 214 KEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPW--EDNLKDPKYV 271 E+ + + H S D+ LG + L+G P+ E N + + + Sbjct: 164 FTA--------PEYYAPEVHQHDVVSTATDMWSLGTLVYVLLSGINPFLAETNQQIIENI 215 Query: 272 RDSKIRYRENIA 283 +++ + E Sbjct: 216 MNAEYTFDEEAF 227 >3NYO-A nrPDB Length = 576 Score = 130 bits (326), Expect = 1e-30, Method: Composition-based stats. Identities = 41/246 (16%), Positives = 80/246 (32%), Gaps = 29/246 (11%) Query: 32 MAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAA 91 + K ++ +G+GGFG + K+ K A Sbjct: 181 VTKNTFRQYRVLGKGGFGEV----------CACQVRATGKMYACKKLEKKRIKKRKGEAM 230 Query: 92 KPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQK-IYEANAKRF 149 + Q + ++ S + K +++ G DL+ IY F Sbjct: 231 ALNEKQILEKVNS-------RFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGF 283 Query: 150 SRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGV 209 + + I LE +H V+ D+K N+LL+ + + + D GLA Sbjct: 284 PEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLD--DHGHIRISDLGLAVHVP---- 337 Query: 210 HKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPK 269 + + GT+ + + + + D LG + + + G P++ K K Sbjct: 338 ----EGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIK 393 Query: 270 YVRDSK 275 + Sbjct: 394 REEVER 399 >3DAK-A nrPDB Length = 290 Score = 130 bits (326), Expect = 1e-30, Method: Composition-based stats. Identities = 38/236 (16%), Positives = 84/236 (35%), Gaps = 32/236 (13%) Query: 35 KEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPE 94 ++++ IG G + A + + ++ + L E++ + Sbjct: 10 DDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQ----- 64 Query: 95 QIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIY-------EANA 146 + + Y+ S + K +++M G + I E + Sbjct: 65 ----------CHHPNIVSYYTSFV----VKDELWLVMKLLSGGSVLDIIKHIVAKGEHKS 110 Query: 147 KRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCP 206 T+ + +L+ LEY+H++ +H D+KA N+LL V + D+G++ Sbjct: 111 GVLDESTIATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGS--VQIADFGVSAFLAT 168 Query: 207 EGVHKEYKEDPKRCHDGTIEFTSIDAHNG-VAPSRRGDLEILGYCMIQWLTGHLPW 261 G + ++ GT + + + + D+ G I+ TG P+ Sbjct: 169 GGDIT--RNKVRKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPY 222 >3OMV-A nrPDB Length = 307 Score = 130 bits (326), Expect = 1e-30, Method: Composition-based stats. Identities = 44/287 (15%), Positives = 99/287 (34%), Gaps = 43/287 (14%) Query: 38 KVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQ 97 + IG G FG +Y V VV P E+ ++ Sbjct: 39 MLSTRIGSGSFGTVYKG--KWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKT------- 89 Query: 98 KWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYEANAKRFSRKTVLQ 156 +++ + + G K ++ GS L K +F ++ Sbjct: 90 --------RHVNILLFMGY-----MTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLID 136 Query: 157 LSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKED 216 ++ + ++Y+H +H D+K++N+ L+ V + D+GLA ++ ++ Sbjct: 137 IARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLT--VKIGDFGLATVKSRWSGSQQVEQP 194 Query: 217 PKRCHDGTIEFTSIDAH---NGVAPSRRGDLEILGYCMIQWLTGHLPWED-NLKDPKYVR 272 G++ + + + + S + D+ G + + +TG LP+ N +D Sbjct: 195 -----TGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFM 249 Query: 273 DSKIRYRENIASLMDKCFPE---------KNKPGEIAKYMETVKLLD 310 + +++ L C K E + + + ++ Sbjct: 250 VGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIE 296 >2F57-A nrPDB Length = 317 Score = 129 bits (325), Expect = 1e-30, Method: Composition-based stats. Identities = 40/235 (17%), Positives = 83/235 (35%), Gaps = 32/235 (13%) Query: 42 PIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIR 101 IG+G G + +A + VK + ++ + + + Sbjct: 52 KIGEGSTGIVCIATEK-----HTGKQVAVKK-----------MDLRKQQRRELLFNEVVI 95 Query: 102 TRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYEANAKRFSRKTVLQLSLR 160 R + V + S L +++M+ G L I R + + + + L Sbjct: 96 MRDYHHDNVVDMYSSYLVGDE----LWVVMEFLEGGALTDIV--THTRMNEEQIATVCLS 149 Query: 161 ILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRC 220 +L L Y+H +H DIK+ ++LL ++ L D+G + E ++ Sbjct: 150 VLRALSYLHNQGVIHRDIKSDSILLTSDG--RIKLSDFGFCAQVSKEV-------PKRKS 200 Query: 221 HDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSK 275 GT + + + + + D+ LG +I+ + G P+ + R Sbjct: 201 LVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRD 255 >4HZS-A nrPDB Length = 341 Score = 129 bits (325), Expect = 2e-30, Method: Composition-based stats. Identities = 52/302 (17%), Positives = 110/302 (36%), Gaps = 42/302 (13%) Query: 35 KEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPE 94 K+ ++ +G G FG + + ++ G VK D Q A + Sbjct: 12 KDLRLLEKLGDGSFGVVRRGEWDAPS--GKTVSVAVKCLKPDVLS--------QPEAMDD 61 Query: 95 QIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTV 154 I++ L + + + +G L + GS L ++ + + F T+ Sbjct: 62 FIREVNAMHSLDHRNLIRLYGVVL---TPPMKMVTELAPLGSLLDRLRK-HQGHFLLGTL 117 Query: 155 LQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYK 214 + ++++ + + Y+ ++H D+ A NLLL ++ V + D+GL H + Sbjct: 118 SRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRD--LVKIGDFGLMRALPQNDDHYVMQ 175 Query: 215 EDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT-GHLPWEDNLKDPKYVRD 273 E K + + ++ S D + G + + T G PW + Sbjct: 176 EHRKVPF----AWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKI 231 Query: 274 SKIRYR--------ENIASLMDKCFPEKNKPGEIAKYMET-----------VKLLDYTEK 314 K R ++I ++M +C+ +KP + ++ ++ L E+ Sbjct: 232 DKEGERLPRPEDCPQDIYNVMVQCWA--HKPEDRPTFVALRDFLLEAQPTDMRALQDFEE 289 Query: 315 PL 316 P Sbjct: 290 PD 291 >5ZTN-A nrPDB Length = 429 Score = 129 bits (325), Expect = 2e-30, Method: Composition-based stats. Identities = 49/265 (18%), Positives = 107/265 (40%), Gaps = 32/265 (12%) Query: 3 RVKAAQAGRQSSAKRHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLA-DMNSSES 61 + + G + + +Q + ++ D ++V IG+G FG + A D + Sbjct: 67 KRQGMTGGP--NNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQH 124 Query: 62 VGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDK 121 V E +F+++AA+ +I + +R + + L + Sbjct: 125 VALKMVR-------------NEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHM---LENF 168 Query: 122 NGKSYRFMIMDRFGSDLQKIYEANA-KRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKA 180 +++ M + +L ++ + N + FS V + + IL L+ +H++ +H D+K Sbjct: 169 TFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKP 228 Query: 181 SNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSR 240 N+LL + + ++D+G + Y + V+ + + + + G Sbjct: 229 ENILLKQQGRSGIKVIDFG-SSCYEHQRVYTYIQSRF---------YRAPEVILGARYGM 278 Query: 241 RGDLEILGYCMIQWLTGHL--PWED 263 D+ LG + + LTG+ P ED Sbjct: 279 PIDMWSLGCILAELLTGYPLLPGED 303 >2XNP-A nrPDB Length = 279 Score = 129 bits (324), Expect = 2e-30, Method: Composition-based stats. Identities = 43/259 (16%), Positives = 98/259 (37%), Gaps = 36/259 (13%) Query: 35 KEWKVGLPIGQGGFG-CIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKP 93 ++++V IG G +G C + + + + + ++ L +E+ Sbjct: 6 EDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLL------ 59 Query: 94 EQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYEANAKR---F 149 R+LK+ + +Y+ + + +++M+ G DL + K Sbjct: 60 ---------RELKHPNIVRYYDRII--DRTNTTLYIVMEYCEGGDLASVITKGTKERQYL 108 Query: 150 SRKTVLQLSLRILDILEYIHE-----HEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRY 204 + VL++ ++ L+ H H +H D+K +N+ L+ K V L D+GLA Sbjct: 109 DEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGK--QNVKLGDFGLARIL 166 Query: 205 CPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDN 264 + + GT + S + N ++ + + D+ LG + + P+ Sbjct: 167 N-------HDTSFAKTFVGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAF 219 Query: 265 LKDPKYVRDSKIRYRENIA 283 + + + ++R Sbjct: 220 SQKELAGKIREGKFRRIPY 238 >5L2Q-C nrPDB Length = 320 Score = 129 bits (323), Expect = 2e-30, Method: Composition-based stats. Identities = 47/254 (18%), Positives = 94/254 (37%), Gaps = 27/254 (10%) Query: 45 QGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRK 104 +G G I + + + ++ + + +G + F R + + + R K Sbjct: 54 RGDQG-IESQEERQGKMLLHTEYSLLSLLHTQDGVVHHHGLFQDRTCEIVEDTESSRMVK 112 Query: 105 LKYLGVPKYWGSG-LHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILD 163 + HD + K+ + + Y KR S + + + ++ Sbjct: 113 KMKKRICLVLDCLCAHDFSDKTADLINLQH--------YVIKEKRLSERETVVIFYDVVR 164 Query: 164 ILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDG 223 ++E +H+ VH D+K N++LN K ++ + ++ L EG D + G Sbjct: 165 VVEALHQKNIVHRDLKLGNMVLN-KRTHRITITNFCLGKHLVSEG-------DLLKDQRG 216 Query: 224 TIEFTSIDAHNGVAP-SRRGDLEILGYCMIQWLTGHLPWEDN--------LKDPKYVRDS 274 + + S D +G + D+ LG + L G P+ D+ +K +Y Sbjct: 217 SPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPFYDSIPQELFRKIKAAEYTIPE 276 Query: 275 KIRYRENIASLMDK 288 R EN L+ K Sbjct: 277 DGRVSENTVCLIRK 290 >5G6V-A nrPDB Length = 324 Score = 129 bits (323), Expect = 3e-30, Method: Composition-based stats. Identities = 46/314 (14%), Positives = 103/314 (32%), Gaps = 47/314 (14%) Query: 34 KKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKP 93 + + +G+G + +Y ++++ + ++ E E+ + Sbjct: 1 METYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLK----- 55 Query: 94 EQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKT 153 LK+ + +K+ ++ + DL++ + + Sbjct: 56 ----------DLKHANIVTLHDIIHTEKS----LTLVFEYLDKDLKQYLDDCGNIINMHN 101 Query: 154 VLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEY 213 V ++L L Y H + +H D+K NLL+N + ++ L D+GLA K Sbjct: 102 VKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERG--ELKLADFGLARA-------KSI 152 Query: 214 KEDPKRCHDGTIEFTSIDAHNGVA-PSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVR 272 T+ + D G S + D+ +G + TG + + + + Sbjct: 153 PTKTYDNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHF 212 Query: 273 DSKIRYRENIASLMDKCFPEKNKPGEIAKY----------METVKLLDYTEKPLYENLRD 322 +I + + ++ +P E Y + LD + L Sbjct: 213 IFRI-----LGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSDGA---DLLTK 264 Query: 323 ILLQGLKAIGSKDD 336 +L + S +D Sbjct: 265 LLQFEGRNRISAED 278 >4KRC-A nrPDB Length = 317 Score = 129 bits (323), Expect = 3e-30, Method: Composition-based stats. Identities = 40/250 (16%), Positives = 93/250 (37%), Gaps = 34/250 (13%) Query: 33 AKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAK 92 + ++K +G G + +Y ++ + VK++ + P Sbjct: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKE--VKLDSEEGTP------------- 47 Query: 93 PEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEA-----NAK 147 I++ ++LK+ + + + + + ++ + +DL+K ++ + Sbjct: 48 STAIREISLMKELKHENIVRLYDVIHTE----NKLTLVFEFMDNDLKKYMDSRTVGNTPR 103 Query: 148 RFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPE 207 V ++L L + HE++ +H D+K NLL+N + Q+ L D+GLA + Sbjct: 104 GLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRG--QLKLGDFGLARAFG-- 159 Query: 208 GVHKEYKEDPKRCHDGTIEFTSIDAHNG-VAPSRRGDLEILGYCMIQWLTGHLPWEDNLK 266 + T+ + + D G S D+ G + + +TG + Sbjct: 160 -----IPVNTFSSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTND 214 Query: 267 DPKYVRDSKI 276 + + I Sbjct: 215 EEQLKLIFDI 224 >4KIK-B nrPDB Length = 677 Score = 128 bits (322), Expect = 3e-30, Method: Composition-based stats. Identities = 44/272 (16%), Positives = 89/272 (32%), Gaps = 25/272 (9%) Query: 26 GEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELK 85 +T W++ +G GGFG + + + C ++ P + E++ Sbjct: 10 SPSLTTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQ 69 Query: 86 FYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYEA 144 +R P + ++ L + M+ G DL+K Sbjct: 70 IMRRLTHPNVVAARDVPEGMQNLA-------------PNDLPLLAMEYCQGGDLRKYLNQ 116 Query: 145 NAK--RFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQV-YLVDYGLA 201 +L L I L Y+HE+ +H D+K N++L + ++D G A Sbjct: 117 FENCCGLREGAILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYA 176 Query: 202 YRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPW 261 + GT+++ + + + D G + +TG P+ Sbjct: 177 KELDQGSL--------CTSFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPF 228 Query: 262 EDNLKDPKYVRDSKIRYRENIASLMDKCFPEK 293 N + ++ + + +I D K Sbjct: 229 LPNWQPVQWHSKVRQKSEVDIVVSEDLNGTVK 260 >4IC8-A nrPDB Length = 442 Score = 128 bits (322), Expect = 3e-30, Method: Composition-based stats. Identities = 43/244 (17%), Positives = 98/244 (40%), Gaps = 21/244 (8%) Query: 33 AKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAK 92 E+++ IG G +G + A + +K P+ F + +R + Sbjct: 53 VGDEYEIIETIGNGAYGVVSSARRR-----LTGQQVAIKKIPN----AFDVVTNAKRTLR 103 Query: 93 PEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRK 152 +I K + + + + + KS ++++D SDL +I ++ + + + Sbjct: 104 ELKILKHFKHDNI--IAIKDILRPTVPYGEFKS-VYVVLDLMESDLHQIIHSS-QPLTLE 159 Query: 153 TVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKE 212 V ++L L+Y+H + +H D+K SNLL+N ++ + D+G+A C + Sbjct: 160 HVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNEN--CELKIGDFGMARGLCTSPAEHQ 217 Query: 213 YKEDPKRCHDGTIEFTSIDAHNGV-APSRRGDLEILGYCMIQWL--TGHLPWEDNLKDPK 269 Y + T + + + + ++ DL +G + L P ++ + + Sbjct: 218 YFMTE---YVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQ 274 Query: 270 YVRD 273 + Sbjct: 275 LIMM 278 >1PHK-A nrPDB Length = 298 Score = 128 bits (322), Expect = 3e-30, Method: Composition-based stats. Identities = 37/247 (14%), Positives = 82/247 (33%), Gaps = 26/247 (10%) Query: 21 EQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPL 80 + G T + ++ +G+G + + VK+ G Sbjct: 3 DAALPGSHSTHGFYENYEPKEILGRGVSSVVRRCIHKPT-----CKEYAVKIIDVTGGGS 57 Query: 81 FTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQK 140 F+ + Q + + I + + + + + + + F++ D Sbjct: 58 FSAEEV-QELREATLKEVDILRKVSGHPNIIQLKDTYETNT----FFFLVFDLMKKGELF 112 Query: 141 IYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGL 200 Y S K ++ +L+++ +H+ VH D+K N+LL+ + + L D+G Sbjct: 113 DYLTEKVTLSEKETRKIMRALLEVICALHKLNIVHRDLKPENILLD--DDMNIKLTDFGF 170 Query: 201 AYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNG------VAPSRRGDLEILGYCMIQW 254 + + P +E GT + + + + D+ G M Sbjct: 171 SCQLDPGEKLREV--------CGTPSYLAPEIIECSMNDNHPGYGKEVDMWSTGVIMYTL 222 Query: 255 LTGHLPW 261 L G P+ Sbjct: 223 LAGSPPF 229 >4ZSG-A nrPDB Length = 347 Score = 128 bits (321), Expect = 4e-30, Method: Composition-based stats. Identities = 43/244 (17%), Positives = 98/244 (40%), Gaps = 21/244 (8%) Query: 33 AKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAK 92 E+++ IG G +G + A + +K P+ F + +R + Sbjct: 5 VGDEYEIIETIGNGAYGVVSSARRR-----LTGQQVAIKKIPN----AFDVVTNAKRTLR 55 Query: 93 PEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRK 152 +I K + + + + + KS ++++D SDL +I ++ + + + Sbjct: 56 ELKILKHFKHDNI--IAIKDILRPTVPYGEFKS-VYVVLDLMESDLHQIIHSS-QPLTLE 111 Query: 153 TVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKE 212 V ++L L+Y+H + +H D+K SNLL+N ++ + D+G+A C + Sbjct: 112 HVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNEN--CELKIGDFGMARGLCTSPAEHQ 169 Query: 213 YKEDPKRCHDGTIEFTSIDAHNGV-APSRRGDLEILGYCMIQWL--TGHLPWEDNLKDPK 269 Y + T + + + + ++ DL +G + L P ++ + + Sbjct: 170 YFMTE---YVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQ 226 Query: 270 YVRD 273 + Sbjct: 227 LIMM 230 >1U54-B nrPDB Length = 291 Score = 128 bits (320), Expect = 6e-30, Method: Composition-based stats. Identities = 50/292 (17%), Positives = 109/292 (37%), Gaps = 31/292 (10%) Query: 20 AEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGP 79 A + + + + +K+ ++ +G G FG + + ++ G VK D Sbjct: 3 AGEGPLQSLTCLIGEKDLRLLEKLGDGSFGVVRRGEWDAPS--GKTVSVAVKCLKPDVLS 60 Query: 80 LFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQ 139 Q A + I++ L + + + +G L + GS L Sbjct: 61 --------QPEAMDDFIREVNAMHSLDHRNLIRLYGVVL---TPPMKMVTELAPLGSLLD 109 Query: 140 KIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYG 199 ++ + + F T+ + ++++ + + Y+ ++H D+ A NLLL ++ V + D+G Sbjct: 110 RLRK-HQGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRD--LVKIGDFG 166 Query: 200 LAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT-GH 258 L H +E K + + ++ S D + G + + T G Sbjct: 167 LMRALPQNDDHYVMQEHRKVPF----AWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQ 222 Query: 259 LPWEDNLKDPKYVRDSKIRYR--------ENIASLMDKCFPEKNKPGEIAKY 302 PW + K R ++I ++M +C+ +KP + + Sbjct: 223 EPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWA--HKPEDRPTF 272 >3OZ6-A nrPDB Length = 388 Score = 128 bits (320), Expect = 6e-30, Method: Composition-based stats. Identities = 39/261 (14%), Positives = 92/261 (35%), Gaps = 36/261 (13%) Query: 29 ITDMAKKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFY 87 + +++++ +G+G +G ++ + D + E V +D F E+ Sbjct: 3 VDRHVLRKYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQNSTDAQRTFREIMIL 62 Query: 88 QRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAK 147 + + + D +++ D +DL + AN Sbjct: 63 TELS--------------GHENIVNLLNVLRAD--NDRDVYLVFDYMETDLHAVIRANI- 105 Query: 148 RFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCP- 206 + +++ +++Y+H +H D+K SN+LLN + V + D+GL+ + Sbjct: 106 -LEPVHKQYVVYQLIKVIKYLHSGGLLHRDMKPSNILLNAE--CHVKVADFGLSRSFVNI 162 Query: 207 -----------EGVHKEYKEDPKR--CHDGTIEFTSIDAHNGVAPSRRG-DLEILGYCMI 252 + + +D + T + + + G +G D+ LG + Sbjct: 163 RRVTNNIPLSINENTENFDDDQPILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILG 222 Query: 253 QWLTGHLPWEDNLKDPKYVRD 273 + L G + + + R Sbjct: 223 EILCGKPIFPGSSTMNQLERI 243 >6B2Q-A nrPDB Length = 317 Score = 128 bits (320), Expect = 6e-30, Method: Composition-based stats. Identities = 44/234 (18%), Positives = 83/234 (35%), Gaps = 22/234 (9%) Query: 32 MAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAA 91 +++ I GG G ++ A N VKV S+ ++ +F +R Sbjct: 29 TLSGRYRLQRLIATGGMGQVWEAVDN-----RLGRRVAVKVLKSE---FSSDPEFIERFR 80 Query: 92 KPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYR-FMIMDRFGSDLQKIYEANAKRFS 150 + T L + G+ G NG+ +++M+ + R S Sbjct: 81 AEART-----TAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLS 135 Query: 151 RKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVH 210 + L + + L+ H VH D+K N+L+ QV + D+G+A Sbjct: 136 LRHALDMLEQTGRALQIAHAAGLVHRDVKPGNILITPTG--QVKITDFGIAKAVD----- 188 Query: 211 KEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDN 264 GT ++ + + G S D+ LG + ++G P+ + Sbjct: 189 -AAPVTQTGMVMGTAQYIAPEQALGHDASPASDVYSLGVVGYEAVSGKRPFAGD 241 >4X3F-A nrPDB Length = 337 Score = 128 bits (320), Expect = 6e-30, Method: Composition-based stats. Identities = 44/234 (18%), Positives = 83/234 (35%), Gaps = 22/234 (9%) Query: 32 MAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAA 91 +++ I GG G ++ A N VKV S+ ++ +F +R Sbjct: 9 TLSGRYRLQRLIATGGMGQVWEAVDN-----RLGRRVAVKVLKSE---FSSDPEFIERFR 60 Query: 92 KPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYR-FMIMDRFGSDLQKIYEANAKRFS 150 + T L + G+ G NG+ +++M+ + R S Sbjct: 61 AEART-----TAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLS 115 Query: 151 RKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVH 210 + L + + L+ H VH D+K N+L+ QV + D+G+A Sbjct: 116 LRHALDMLEQTGRALQIAHAAGLVHRDVKPGNILITPTG--QVKITDFGIAKAVD----- 168 Query: 211 KEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDN 264 GT ++ + + G S D+ LG + ++G P+ + Sbjct: 169 -AAPVTQTGMVMGTAQYIAPEQALGHDASPASDVYSLGVVGYEAVSGKRPFAGD 221 >4OW8-A nrPDB Length = 283 Score = 128 bits (320), Expect = 6e-30, Method: Composition-based stats. Identities = 44/234 (18%), Positives = 83/234 (35%), Gaps = 22/234 (9%) Query: 32 MAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAA 91 +++ I GG G ++ A N VKV S+ ++ +F +R Sbjct: 8 TLSGRYRLQRLIATGGMGQVWEAVDN-----RLGRRVAVKVLKSE---FSSDPEFIERFR 59 Query: 92 KPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYR-FMIMDRFGSDLQKIYEANAKRFS 150 + T L + G+ G NG+ +++M+ + R S Sbjct: 60 AEART-----TAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLS 114 Query: 151 RKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVH 210 + L + + L+ H VH D+K N+L+ QV + D+G+A Sbjct: 115 LRHALDMLEQTGRALQIAHAAGLVHRDVKPGNILITPTG--QVKITDFGIAKAVD----- 167 Query: 211 KEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDN 264 GT ++ + + G S D+ LG + ++G P+ + Sbjct: 168 -AAPVTQTGMVMGTAQYIAPEQALGHDASPASDVYSLGVVGYEAVSGKRPFAGD 220 >5FET-A nrPDB Length = 847 Score = 127 bits (319), Expect = 7e-30, Method: Composition-based stats. Identities = 43/255 (16%), Positives = 92/255 (36%), Gaps = 33/255 (12%) Query: 18 HLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDN 77 HL E+ + + +M E + IG+G FG + L ++ +K + Sbjct: 518 HLEERIKMQDTKVEM--HELETERIIGRGTFGTVKLVHHKPTQI-----RYALKCVSKRS 570 Query: 78 GPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GS 136 + + + T + + + + + + + + + G Sbjct: 571 IISLNQQNNIKLERE--------ITAENDHPFIIRLVRT----FKDSNCFYFLTELVTGG 618 Query: 137 DLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLV 196 +L S+ I+ +EY+HE V+ D+K N+LL+ V L+ Sbjct: 619 ELYDAI-RKLGLLSKPQAQFYLGSIILAIEYLHERNIVYRDLKPENILLD--KQGYVKLI 675 Query: 197 DYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT 256 D+G A + + GT + + + G D+ LG C+ +++ Sbjct: 676 DFGCAKKI----------QGRAYTLVGTPHYMAPEVILGKGYGCTVDIWALGVCLYEFIC 725 Query: 257 GHLPWEDNLKDPKYV 271 G LP+ ++ +D + Sbjct: 726 GPLPFGNDQEDQLEI 740 >4U41-A nrPDB Length = 332 Score = 127 bits (319), Expect = 7e-30, Method: Composition-based stats. Identities = 38/233 (16%), Positives = 81/233 (34%), Gaps = 34/233 (14%) Query: 37 WKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQI 96 +++ +G G +G +Y + + + V+ V + + E+ ++ + Sbjct: 26 FELVEVVGNGTYGQVYKGRHVKTGQLAAIK--VMDVTEDEEEEIKLEINMLKKYSH---- 79 Query: 97 QKWIRTRKLKYLGVPKYWGSGLHDKNG--KSYRFMIMDRFG-SDLQKIY-EANAKRFSRK 152 + + Y+G+ + +++M+ G + + Sbjct: 80 ----------HRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKED 129 Query: 153 TVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKE 212 + +S IL L ++H H +H DIK N+LL +V LVD+G++ + Sbjct: 130 WIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTEN--AEVKLVDFGVSAQLDRTV---- 183 Query: 213 YKEDPKRCHDGTIEFTSIDAHNGVA-----PSRRGDLEILGYCMIQWLTGHLP 260 + GT + + + R DL G I+ G P Sbjct: 184 ---GRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPP 233 >6GU6-A nrPDB Length = 302 Score = 127 bits (319), Expect = 7e-30, Method: Composition-based stats. Identities = 42/246 (17%), Positives = 92/246 (37%), Gaps = 30/246 (12%) Query: 33 AKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAK 92 + +++ IG+G +G +Y ++ V A +++E + G Sbjct: 5 SMEDYTKIEKIGEGTYGVVYKGRHKTTGQV--VAMKKIRLESEEEGV------------P 50 Query: 93 PEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEA--NAKRFS 150 I++ ++L++ + + D S ++I + DL+K ++ + Sbjct: 51 STAIREISLLKELRHPNIVSLQDVLMQD----SRLYLIFEFLSMDLKKYLDSIPPGQYMD 106 Query: 151 RKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVH 210 V +IL + + H +H D+K NLL++ K + L D+GLA + Sbjct: 107 SSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGT--IKLADFGLARAFG----- 159 Query: 211 KEYKEDPKRCHDGTIEFTSIDAHNGVA-PSRRGDLEILGYCMIQWLTGHLPWEDNLKDPK 269 + T+ + S + G A S D+ +G + T + + + + Sbjct: 160 IPIRVYTHEVV--TLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQ 217 Query: 270 YVRDSK 275 R + Sbjct: 218 LFRIFR 223 >1UA2-A nrPDB Length = 346 Score = 127 bits (319), Expect = 8e-30, Method: Composition-based stats. Identities = 45/264 (17%), Positives = 93/264 (35%), Gaps = 31/264 (11%) Query: 35 KEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKP 93 K ++ +G+G F +Y A D N+++ V + Sbjct: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIK------------LGHRSEAKDGINR 57 Query: 94 EQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKT 153 +++ ++L + + + H KS ++ D +DL+ I + N+ + Sbjct: 58 TALREIKLLQELSHPNIIGLLDAFGH----KSNISLVFDFMETDLEVIIKDNSLVLTPSH 113 Query: 154 VLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEY 213 + L L LEY+H+H +H D+K +NLLL+ + L D+GLA + Sbjct: 114 IKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENG--VLKLADFGLAKSFGS------- 164 Query: 214 KEDPKRCHDGTIEFTSIDAHNG-VAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVR 272 T + + + G D+ +G + + L +P+ D + Sbjct: 165 PNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLT 223 Query: 273 DSKIRYRENIASLMDKCFPEKNKP 296 + ++ + P Sbjct: 224 RI---FETLGTPTEEQWPDMCSLP 244 >3E7O-A nrPDB Length = 360 Score = 127 bits (318), Expect = 9e-30, Method: Composition-based stats. Identities = 38/307 (12%), Positives = 105/307 (34%), Gaps = 36/307 (11%) Query: 16 KRHLAEQFAVGEIITDM--AKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVE 73 H+ QF ++ K ++ PIG G G + + ++V V K+ Sbjct: 1 GSHMDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIV----CAAFDTVLGINVAVKKLS 56 Query: 74 PSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDK--NGKSYRFMIM 131 + + ++ + + + + + K +++M Sbjct: 57 RPFQNQTHAKRAY----------RELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVM 106 Query: 132 DRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPD 191 + ++L ++ + + L ++L ++++H +H D+K SN+++ K+ Sbjct: 107 ELMDANLCQVIHMELDH---ERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVV--KSDC 161 Query: 192 QVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCM 251 + ++D+GLA + Y + + + G+ D+ +G M Sbjct: 162 TLKILDFGLARTASTNFMMTPYVVTRY--------YRAPEVILGMGYKENVDIWSVGCIM 213 Query: 252 IQWLTGHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDY 311 + + G + ++ ++ + + + + +N Y + + Sbjct: 214 GELVKGSVIFQGTDHIDQWNKVIEQLGTPSAEFMAALQPTVRNYVENRPAY----PGIAF 269 Query: 312 TEK-PLY 317 E P + Sbjct: 270 EELFPDW 276 >5UUU-A nrPDB Length = 547 Score = 127 bits (318), Expect = 1e-29, Method: Composition-based stats. Identities = 44/242 (18%), Positives = 83/242 (34%), Gaps = 28/242 (11%) Query: 32 MAKKEWKVGLPIGQGGFGCIYLAD-MNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRA 90 + ++ V IG+GGFG +Y ++ + +++ L + Sbjct: 195 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIML-- 252 Query: 91 AKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFS 150 L G + + + I+D + + FS Sbjct: 253 -------------SLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFS 299 Query: 151 RKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVH 210 + + I+ LE++H V+ D+K +N+LL+ V + D GLA + + H Sbjct: 300 EADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHG--HVRISDLGLACDFSKKKPH 357 Query: 211 KEYKEDPKRCHDGTIEFTSIDAH-NGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPK 269 GT + + + GVA D LG + + L GH P+ + K Sbjct: 358 ---------ASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK 408 Query: 270 YV 271 + Sbjct: 409 HE 410 >4BGQ-A nrPDB Length = 304 Score = 127 bits (318), Expect = 1e-29, Method: Composition-based stats. Identities = 34/231 (14%), Positives = 86/231 (37%), Gaps = 26/231 (11%) Query: 33 AKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAK 92 ++++ +G+G +G + + + + K + S+ E Sbjct: 10 VMNKFEILGVVGEGAYGVVLKCRHKETHEI----VAIKKFKDSEENEEVKE--------- 56 Query: 93 PEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRK 152 +++ R LK + + + +++ + ++ ++ E + Sbjct: 57 -TTLRELKMLRTLKQENIVEL----KEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPE 111 Query: 153 TVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKE 212 V +++ + + H+++ VH DIK NLL+++ + + L D+G A EG + Sbjct: 112 KVKSYIYQLIKAIHWCHKNDIVHRDIKPENLLISHND--VLKLCDFGFARNL-SEGNNAN 168 Query: 213 YKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWED 263 Y E+ T + S + G + D+ +G + + G + Sbjct: 169 YDEE-----VATRWYRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPG 214 >4XEY-B nrPDB Length = 408 Score = 127 bits (318), Expect = 1e-29, Method: Composition-based stats. Identities = 46/308 (14%), Positives = 101/308 (32%), Gaps = 43/308 (13%) Query: 30 TDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQR 89 TD+ K +G G +G +Y + + A +K + + E + Sbjct: 125 TDITMKH-----KLGGGQYGEVYEGVWK--KYSLTVAVKTLKEDTMEVEEFLKEAAVMKE 177 Query: 90 AAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRF 149 P +Q G+ + Y +G+ L + E N + Sbjct: 178 IKHPNLVQLL-----------------GVCTREPPFYIITEFMTYGNLLDYLRECNRQEV 220 Query: 150 SRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGV 209 + +L ++ +I +EY+ + ++H D+ A N L+ V + D+GL+ + Sbjct: 221 NAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGEN--HLVKVADFGLSRLMTGD-- 276 Query: 210 HKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT-GHLPWEDNLKDP 268 I++T+ ++ S + D+ G + + T G P+ Sbjct: 277 ----TYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQ 332 Query: 269 KYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDILLQGL 328 Y K E + P ++ + M + +++P + + Sbjct: 333 VYELLEKDYRMERP----------EGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMF 382 Query: 329 KAIGSKDD 336 + D+ Sbjct: 383 QESSISDE 390 >4AN9-A nrPDB Length = 301 Score = 127 bits (318), Expect = 1e-29, Method: Composition-based stats. Identities = 47/317 (14%), Positives = 116/317 (36%), Gaps = 47/317 (14%) Query: 24 AVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTE 83 A+GE+ D +++ +G G G ++ S V + ++++P+ + E Sbjct: 2 ALGELKDD----DFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRE 57 Query: 84 LKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYE 143 L+ + + ++G+ D + M+ Sbjct: 58 LQVL---------------HECNSPYIVGFYGAFYSDGE----ISICMEHMDGGSLDQVL 98 Query: 144 ANAKRFSRKTVLQLSLRILDILEYI-HEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAY 202 A R + + ++S+ ++ L Y+ +H+ +H D+K SN+L+N + ++ L D+G++ Sbjct: 99 KKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRG--EIKLCDFGVSG 156 Query: 203 RYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWE 262 + E ++ GT + S + G S + D+ +G +++ G P Sbjct: 157 QLIDEMANE---------FVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYP-- 205 Query: 263 DNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRD 322 + P + + I + P E ++ + + E+ L+ Sbjct: 206 ---RPPMAI----FELLDYIVNEPPPKLPSAVFSLEFQDFVNKCLIKNPAERAD---LKQ 255 Query: 323 ILLQGLKAIGSKDDGKL 339 +++ ++ Sbjct: 256 LMVHAFIKRSDAEEVDF 272 >5AWM-A nrPDB Length = 394 Score = 126 bits (317), Expect = 1e-29, Method: Composition-based stats. Identities = 41/301 (13%), Positives = 105/301 (34%), Gaps = 38/301 (12%) Query: 11 RQSSAKRHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVV 70 R + +H VG+ + PIG G G + + +++ + Sbjct: 21 RTMTTAQHQHYTVEVGD-TNFTIHSRYINLRPIGSGAQGIV----CAAYDTITQQNVAIK 75 Query: 71 KVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKL-KYLGVPKYWGSGL--HDKNGKSYR 127 K+ + +Q ++ + + KL + + + + Sbjct: 76 KLS-----------RPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDV 124 Query: 128 FMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY 187 +++M+ ++L ++ + + + L ++L ++++H +H D+K SN+++ Sbjct: 125 YLVMELMDANLCQVIQMDLDH---DRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVV-- 179 Query: 188 KNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEIL 247 K + ++D+GLA + Y + + + G+ + D+ + Sbjct: 180 KADCTLKILDFGLARTAGTTFMMTPYVVTRY--------YRAPEVILGMGYTENVDIWSV 231 Query: 248 GYCMIQWLTG--HLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPE-KNKPGEIAKYME 304 G M + + G P D++ + + S M + P +N +Y Sbjct: 232 GCIMGEMIRGGVLFPGTDHIDQWNKII---EQLGTPSPSFMQRLQPTVRNYVENRPRYTG 288 Query: 305 T 305 Sbjct: 289 Y 289 >5DBX-A nrPDB Length = 328 Score = 126 bits (317), Expect = 1e-29, Method: Composition-based stats. Identities = 37/236 (15%), Positives = 82/236 (34%), Gaps = 32/236 (13%) Query: 35 KEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPE 94 +++ IG G + A + + ++ + L E++ + + Sbjct: 11 DAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQCS--- 67 Query: 95 QIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYEANAKR----- 148 + V Y+ S + K +++M G + I + R Sbjct: 68 ------------HPNVVTYYTSFV----VKDELWLVMKLLSGGSMLDIIKYIVNRGEHKN 111 Query: 149 --FSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCP 206 + + +L+ L+Y+H + +H D+KA N+LL V + D+G++ Sbjct: 112 GVLEEAIIATILKEVLEGLDYLHRNGQIHRDLKAGNILLGEDGS--VQIADFGVSAFLAT 169 Query: 207 EGVHKEYKEDPKRCHDGTIEFTSIDAHNG-VAPSRRGDLEILGYCMIQWLTGHLPW 261 G + ++ GT + + + + D+ G I+ TG P+ Sbjct: 170 GGDVT--RNKVRKDFVGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPY 223 >4E93-A nrPDB Length = 377 Score = 126 bits (317), Expect = 1e-29, Method: Composition-based stats. Identities = 45/280 (16%), Positives = 97/280 (34%), Gaps = 37/280 (13%) Query: 39 VGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQK 98 +G IG+G FG ++ + + ++ + C + P E + ++ Sbjct: 118 LGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQ--------- 168 Query: 99 WIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYEANAKRFSRKTVLQL 157 + + + G K +++M+ G D R KT+LQ+ Sbjct: 169 ------YSHPNIVRLIGV----CTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQM 218 Query: 158 SLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDP 217 +EY+ +H D+ A N L+ KN + + D+G++ Sbjct: 219 VGDAAAGMEYLESKCCIHRDLAARNCLVTEKN--VLKISDFGMSREEADGVYAASGGLRQ 276 Query: 218 KRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQ-WLTGHLPWEDNLKDPKYVRDSKI 276 +++T+ +A N S D+ G + + + G P+ + K Sbjct: 277 V-----PVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKG 331 Query: 277 RYR-------ENIASLMDKCFPEKNKPGEIAKYMETVKLL 309 + + LM++C+ + PG+ + + L Sbjct: 332 GRLPCPELCPDAVFRLMEQCWAYE--PGQRPSFSTIYQEL 369 >6NPU-A nrPDB Length = 298 Score = 126 bits (316), Expect = 1e-29, Method: Composition-based stats. Identities = 46/308 (14%), Positives = 101/308 (32%), Gaps = 43/308 (13%) Query: 30 TDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQR 89 TD+ K +G G +G +Y + + A +K + + E + Sbjct: 26 TDITMKH-----KLGGGQYGEVYEGVWK--KYSLTVAVKTLKEDTMEVEEFLKEAAVMKE 78 Query: 90 AAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRF 149 P +Q G+ + Y +G+ L + E N + Sbjct: 79 IKHPNLVQLL-----------------GVCTREPPFYIITEFMTYGNLLDYLRECNRQEV 121 Query: 150 SRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGV 209 + +L ++ +I +EY+ + ++H D+ A N L+ V + D+GL+ + Sbjct: 122 NAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGEN--HLVKVADFGLSRLMTGD-- 177 Query: 210 HKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT-GHLPWEDNLKDP 268 I++T+ ++ S + D+ G + + T G P+ Sbjct: 178 ----TYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQ 233 Query: 269 KYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDILLQGL 328 Y K E + P ++ + M + +++P + + Sbjct: 234 VYELLEKDYRMERP----------EGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMF 283 Query: 329 KAIGSKDD 336 + D+ Sbjct: 284 QESSISDE 291 >5TQX-A nrPDB Length = 655 Score = 126 bits (316), Expect = 2e-29, Method: Composition-based stats. Identities = 40/233 (17%), Positives = 87/233 (37%), Gaps = 26/233 (11%) Query: 33 AKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAK 92 A W++ +G GGFG + L + + C +++ + E++ ++ Sbjct: 6 AGGPWEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCHEIQIMKKLNH 65 Query: 93 PEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYEANAK--RF 149 ++ +L L +HD + M+ G DL+K+ Sbjct: 66 ANVVKACDVPEELNIL---------IHDVP-----LLAMEYCSGGDLRKLLNKPENCCGL 111 Query: 150 SRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQV-YLVDYGLAYRYCPEG 208 +L L I + Y+HE++ +H D+K N++L + ++D G A Sbjct: 112 KESQILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGE 171 Query: 209 VHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPW 261 + E+ GT+++ + + + D G + + + G+ P+ Sbjct: 172 LCTEF--------VGTLQYLAPELFENKPYTATVDYWSFGTMVFECIAGYRPF 216 >4UYA-A nrPDB Length = 340 Score = 126 bits (316), Expect = 2e-29, Method: Composition-based stats. Identities = 55/299 (18%), Positives = 105/299 (35%), Gaps = 48/299 (16%) Query: 32 MAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAA 91 +A + ++ IG GGFG +Y A VK D AA Sbjct: 23 VAFERLELKELIGAGGFGQVYRA-------TWQGQEVAVKAARQDPEQDAA-------AA 68 Query: 92 KPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDR-FGSDLQKIYEANAKRFS 150 ++ L++ + + G L + + ++++ G L + +R Sbjct: 69 AESVRREARLFAMLRHPNIIELRGVCL----QQPHLCLVLEFARGGALNRALA--GRRIP 122 Query: 151 RKTVLQLSLRILDILEYIHEHE---YVHGDIKASNLLLNYKNPDQ------VYLVDYGLA 201 ++ +++I + Y+HE +H D+K+SN+LL K + + D+GLA Sbjct: 123 PHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLA 182 Query: 202 YRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPW 261 E+ K G + + + S+ D+ G + + LTG +P+ Sbjct: 183 R---------EWHRTTKMATAGAYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPY 233 Query: 262 EDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENL 320 D V + + + C P AK M+ D +P + + Sbjct: 234 RGI--DGLAVAYG-VAVNKLTLPIPSTC------PEPFAKLMKECWQQDPHIRPSFALI 283 >3PVW-A nrPDB Length = 695 Score = 126 bits (315), Expect = 2e-29, Method: Composition-based stats. Identities = 44/242 (18%), Positives = 83/242 (34%), Gaps = 28/242 (11%) Query: 32 MAKKEWKVGLPIGQGGFGCIYLAD-MNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRA 90 + ++ V IG+GGFG +Y ++ + +++ L + Sbjct: 186 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIML-- 243 Query: 91 AKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFS 150 L G + + + I+D + + FS Sbjct: 244 -------------SLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFS 290 Query: 151 RKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVH 210 + + I+ LE++H V+ D+K +N+LL+ V + D GLA + + H Sbjct: 291 EADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHG--HVRISDLGLACDFSKKKPH 348 Query: 211 KEYKEDPKRCHDGTIEFTSIDAH-NGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPK 269 GT + + + GVA D LG + + L GH P+ + K Sbjct: 349 ---------ASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK 399 Query: 270 YV 271 + Sbjct: 400 HE 401 >5Z33-A nrPDB Length = 425 Score = 126 bits (315), Expect = 2e-29, Method: Composition-based stats. Identities = 49/292 (16%), Positives = 107/292 (36%), Gaps = 33/292 (11%) Query: 32 MAKKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRA 90 + + + V +GQG +G + A + +SE V V F++ +RA Sbjct: 28 IVDERYTVTKELGQGAYGIVCAAVNNQTSEGVAIKKVTNV----------FSKKILAKRA 77 Query: 91 AKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFS 150 + ++ + R + + + + + + ++ + DL I + + + Sbjct: 78 LREIKLLQHFR----GHRNITCLYDMDIPRPDNFNETYLYEELMECDLAAII-RSGQPLT 132 Query: 151 RKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRY-CPEGV 209 +IL L+YIH +H D+K NLL+N ++ + D+GLA + Sbjct: 133 DAHFQSFIYQILCGLKYIHSANVLHRDLKPGNLLVNAD--CELKICDFGLARGFSVDPEE 190 Query: 210 HKEYKEDPKRCHDGTIEFTSID-AHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDP 268 + Y + + T + + + + + ++ D+ +G + + L G P+ K Sbjct: 191 NAGYMTE----YVATRWYRAPEIMLSFQSYTKAIDVWSVGCILAELLGGR-PF---FKGR 242 Query: 269 KYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENL 320 YV + + + E V+ L + K + L Sbjct: 243 DYVDQLNQILHILGTPNEETLSRIGSPRAQ-----EYVRNLPFMAKKPFPTL 289 >2FO0-A nrPDB Length = 495 Score = 126 bits (315), Expect = 2e-29, Method: Composition-based stats. Identities = 45/308 (14%), Positives = 101/308 (32%), Gaps = 43/308 (13%) Query: 30 TDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQR 89 TD+ K +G G +G +Y + + A +K + + E + Sbjct: 217 TDITMKH-----KLGGGQYGEVYEGVWK--KYSLTVAVKTLKEDTMEVEEFLKEAAVMKE 269 Query: 90 AAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRF 149 P +Q G+ + Y +G+ L + E N + Sbjct: 270 IKHPNLVQLL-----------------GVCTREPPFYIITEFMTYGNLLDYLRECNRQEV 312 Query: 150 SRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGV 209 + +L ++ +I +EY+ + ++H ++ A N L+ V + D+GL+ + Sbjct: 313 NAVVLLYMATQISSAMEYLEKKNFIHRNLAARNCLVGEN--HLVKVADFGLSRLMTGD-- 368 Query: 210 HKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT-GHLPWEDNLKDP 268 I++T+ ++ S + D+ G + + T G P+ Sbjct: 369 ----TYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQ 424 Query: 269 KYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDILLQGL 328 Y K E + P ++ + M + +++P + + Sbjct: 425 VYELLEKDYRMERP----------EGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMF 474 Query: 329 KAIGSKDD 336 + D+ Sbjct: 475 QESSISDE 482 >1G3N-A nrPDB Length = 326 Score = 125 bits (314), Expect = 3e-29, Method: Composition-based stats. Identities = 34/245 (13%), Positives = 93/245 (37%), Gaps = 24/245 (9%) Query: 35 KEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKP 93 ++++ IG+G +G ++ A D+ + + V+V+ + G + ++ Sbjct: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKR--VRVQTGEEGMPLSTIR-------- 60 Query: 94 EQIQKWIRTRKLKYLGVPKYWG-SGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKR-FSR 151 ++ ++ V + + + + ++ ++ + DL + + Sbjct: 61 -EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPT 119 Query: 152 KTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHK 211 +T+ + ++L L+++H H VH D+K N+L+ Q+ L D+GLA Y + Sbjct: 120 ETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSG--QIKLADFGLARIYSFQMALT 177 Query: 212 EYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYV 271 T+ + + + + + DL +G + + + + Sbjct: 178 SVVV--------TLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLG 229 Query: 272 RDSKI 276 + + Sbjct: 230 KILDV 234 >3QA8-A nrPDB Length = 676 Score = 125 bits (314), Expect = 3e-29, Method: Composition-based stats. Identities = 44/272 (16%), Positives = 90/272 (33%), Gaps = 25/272 (9%) Query: 26 GEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELK 85 + W++ +G GGFG + + + C ++ P + E++ Sbjct: 5 SPSLPTQTCGPWEMKERLGTGGFGYVLRWIHQDTGEQVAIKQCRQELSPKNRERWCLEIQ 64 Query: 86 FYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYEA 144 ++ P + L+ L + M+ G DL+K Sbjct: 65 IMKKLNHPNVVSAREVPDGLQKLA-------------PNDLPLLAMEYCEGGDLRKYLNQ 111 Query: 145 NAK--RFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQV-YLVDYGLA 201 + L I L Y+HE+ +H D+K N++L + ++D G A Sbjct: 112 FENCCGLKEGPIRTLLSDISSALRYLHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYA 171 Query: 202 YRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPW 261 + E+ GT+++ + + + D G + +TG P+ Sbjct: 172 KELDQGELCTEF--------VGTLQYLAPELLEQKKYTVTVDYWSFGTLAFECITGFRPF 223 Query: 262 EDNLKDPKYVRDSKIRYRENIASLMDKCFPEK 293 N + ++ + + E+I D K Sbjct: 224 LPNWQPVQWHGKVREKSNEHIVVYDDLTGAVK 255 >4AGU-A nrPDB Length = 311 Score = 125 bits (313), Expect = 4e-29, Method: Composition-based stats. Identities = 33/229 (14%), Positives = 80/229 (34%), Gaps = 28/229 (12%) Query: 34 KKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKP 93 ++++ IG+G +G ++ + + + K S++ P+ ++ Sbjct: 2 MEKYEKIGKIGEGSYGVVFKCRNRDTGQI----VAIKKFLESEDDPVIKKIA-------- 49 Query: 94 EQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKT 153 +++ ++LK+ + L K ++ + + + + Sbjct: 50 --LREIRMLKQLKHPNLVNL----LEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEHL 103 Query: 154 VLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEY 213 V ++ + L + + H+H +H D+K N+L+ + L D+G A Sbjct: 104 VKSITWQTLQAVNFCHKHNCIHRDVKPENILITKH--SVIKLCDFGFARLL-------TG 154 Query: 214 KEDPKRCHDGTIEFTSIDAHNGVAP-SRRGDLEILGYCMIQWLTGHLPW 261 D T + S + G D+ +G + L+G W Sbjct: 155 PSDYYDDEVATRWYRSPELLVGDTQYGPPVDVWAIGCVFAELLSGVPLW 203 >5KKR-C nrPDB Length = 395 Score = 125 bits (313), Expect = 4e-29, Method: Composition-based stats. Identities = 41/243 (16%), Positives = 95/243 (39%), Gaps = 35/243 (14%) Query: 19 LAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNG 78 L ++ VGE+ D +++ +G G G ++ S V + ++++P+ Sbjct: 56 LTQKQKVGELKDD----DFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRN 111 Query: 79 PLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDL 138 + EL+ + + ++G+ D + M+ Sbjct: 112 QIIRELQVL---------------HECNSPYIVGFYGAFYSDGE----ISICMEHMDGGS 152 Query: 139 QKIYEANAKRFSRKTVLQLSLRILDILEYI-HEHEYVHGDIKASNLLLNYKNPDQVYLVD 197 A R + + ++S+ ++ L Y+ +H+ +H D+K SN+L+N + ++ L D Sbjct: 153 LDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRG--EIKLCD 210 Query: 198 YGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTG 257 +G++ + + GT + S + G S + D+ +G +++ G Sbjct: 211 FGVSGQLIDSMAN---------SFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVG 261 Query: 258 HLP 260 P Sbjct: 262 RYP 264 >3EQC-A nrPDB Length = 360 Score = 125 bits (313), Expect = 4e-29, Method: Composition-based stats. Identities = 41/243 (16%), Positives = 95/243 (39%), Gaps = 35/243 (14%) Query: 19 LAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNG 78 L ++ VGE+ D +++ +G G G ++ S V + ++++P+ Sbjct: 21 LTQKQKVGELKDD----DFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRN 76 Query: 79 PLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDL 138 + EL+ + + ++G+ D + M+ Sbjct: 77 QIIRELQVL---------------HECNSPYIVGFYGAFYSDGE----ISICMEHMDGGS 117 Query: 139 QKIYEANAKRFSRKTVLQLSLRILDILEYI-HEHEYVHGDIKASNLLLNYKNPDQVYLVD 197 A R + + ++S+ ++ L Y+ +H+ +H D+K SN+L+N + ++ L D Sbjct: 118 LDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRG--EIKLCD 175 Query: 198 YGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTG 257 +G++ + + GT + S + G S + D+ +G +++ G Sbjct: 176 FGVSGQLIDSMAN---------SFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVG 226 Query: 258 HLP 260 P Sbjct: 227 RYP 229 >5H2U-A nrPDB Length = 267 Score = 125 bits (313), Expect = 4e-29, Method: Composition-based stats. Identities = 47/288 (16%), Positives = 103/288 (35%), Gaps = 40/288 (13%) Query: 35 KEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPE 94 +E+ + +G G FG ++ +KV DN + Sbjct: 6 EEFTLCRKLGSGYFGEVFEGLWKDR------VQVAIKVISRDN------------LLHQQ 47 Query: 95 QIQKWIR-TRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKT 153 +Q I+ +KL++ + + + Y + GS L+ + +++ K Sbjct: 48 MLQSEIQAMKKLRHKHILALY--AVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSE 105 Query: 154 VLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEY 213 +L ++ ++ + + Y+ Y+H D+ A N+L+ + D+GLA + Sbjct: 106 LLDIAWQVAEGMCYLESQNYIHRDLAARNILVGENTLC--KVGDFGLARLIKEDVYLSHD 163 Query: 214 KEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWL-TGHLPW------EDNLK 266 P + +T+ +A + S + D+ G + + G +P+ E L+ Sbjct: 164 HNIPYK-------WTAPEALSRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLR 216 Query: 267 -DPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTE 313 D Y + ++ LM C+ P + + + L Sbjct: 217 VDAGYRMPCPLECPPSVHKLMLTCWC--RDPEQRPTFKALRERLSSFT 262 >2XYN-A nrPDB Length = 292 Score = 124 bits (311), Expect = 6e-29, Method: Composition-based stats. Identities = 47/283 (16%), Positives = 96/283 (33%), Gaps = 46/283 (16%) Query: 30 TDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQR 89 TD+ K +G G +G +Y+ + + A +K + + E + Sbjct: 32 TDITMKH-----KLGGGQYGEVYVGVWK--KYSLTVAVKTLKEDTMEVEEFLKEAAVMKE 84 Query: 90 AAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF--GSDLQKIYEANAK 147 P +Q LGV + +++ + G+ L + E N + Sbjct: 85 IKHPNLVQ---------LLGVCTL----------EPPFYIVTEYMPYGNLLDYLRECNRE 125 Query: 148 RFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPE 207 + +L ++ +I +EY+ + ++H D+ A N L+ V + D+GL+ + Sbjct: 126 EVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGEN--HVVKVADFGLSRLMTGD 183 Query: 208 GVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT-GHLPWEDNLK 266 I++T+ ++ S + D+ G + + T G P+ Sbjct: 184 ------TYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDL 237 Query: 267 DPKYVRDSKIRYRENI-------ASLMDKCFPEKNKPGEIAKY 302 Y K E LM C+ P + + Sbjct: 238 SQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWS--PADRPSF 278 >1S9I-A nrPDB Length = 354 Score = 124 bits (311), Expect = 6e-29, Method: Composition-based stats. Identities = 41/243 (16%), Positives = 95/243 (39%), Gaps = 35/243 (14%) Query: 19 LAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNG 78 L ++ VGE+ D +++ +G G G + S + + ++++P+ Sbjct: 4 LTQKAKVGELKDD----DFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRN 59 Query: 79 PLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDL 138 + EL+ + + ++G+ D + M+ Sbjct: 60 QIIRELQVL---------------HECNSPYIVGFYGAFYSDGE----ISICMEHMDGGS 100 Query: 139 QKIYEANAKRFSRKTVLQLSLRILDILEYI-HEHEYVHGDIKASNLLLNYKNPDQVYLVD 197 AKR + + ++S+ +L L Y+ +H+ +H D+K SN+L+N + ++ L D Sbjct: 101 LDQVLKEAKRIPEEILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRG--EIKLCD 158 Query: 198 YGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTG 257 +G++ + + GT + + + G S + D+ +G +++ G Sbjct: 159 FGVSGQLIDSMAN---------SFVGTRSYMAPERLQGTHYSVQSDIWSMGLSLVELAVG 209 Query: 258 HLP 260 P Sbjct: 210 RYP 212 >3C51-A nrPDB Length = 543 Score = 124 bits (311), Expect = 6e-29, Method: Composition-based stats. Identities = 56/323 (17%), Positives = 105/323 (32%), Gaps = 44/323 (13%) Query: 41 LPIGQGGFGCIYLADMN-SSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKW 99 +G+GGFG ++ M + + N + K YQ A ++I Sbjct: 191 RVLGRGGFGEVFACQMKATGKLYACKKL---------NKKRLKKRKGYQGAMVEKKILAK 241 Query: 100 IRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANA--KRFSRKTVLQL 157 + +R + L + M + G IY + F + Sbjct: 242 VHSRFIVSLA-------YAFETKTDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFY 294 Query: 158 SLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDP 217 + +I+ LE++H+ ++ D+K N+LL+ + V + D GLA Sbjct: 295 TAQIVSGLEHLHQRNIIYRDLKPENVLLD--DDGNVRISDLGLAVELKAGQT-------K 345 Query: 218 KRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIR 277 + + GT F + + G D LG + + + P+ + + ++ K R Sbjct: 346 TKGYAGTPGFMAPELLLGEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVEN-KELKQR 404 Query: 278 YRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRD--ILLQGLKAIGSKD 335 E + DK P E + K L + + + LR + Sbjct: 405 VLEQAVTYPDKFSPASKDFCEALLQKDPEKRLGFRDG-SCDGLRTHPLFRDI-------- 455 Query: 336 DGKLDLSVVENGGLKAKTITKKR 358 +E G L + R Sbjct: 456 ----SWRQLEAGMLTPPFVPDSR 474 >6DTL-A nrPDB Length = 364 Score = 124 bits (310), Expect = 7e-29, Method: Composition-based stats. Identities = 42/219 (19%), Positives = 80/219 (36%), Gaps = 33/219 (15%) Query: 42 PIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWI 100 PIG+G +G + A + ++ESV F + +++ Sbjct: 37 PIGKGAYGIVCSAMNSETNESVAIKKIA---------------NAFDNKIDAKRTLREIK 81 Query: 101 RTRKLKYLGVPKYWG---SGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQL 157 R + + + L + Y + + +DL +I +N + S + Sbjct: 82 LLRHMDHENIVAIRDIIPPPLRNAFNDVY--IAYELMDTDLHQIIRSN-QALSEEHCQYF 138 Query: 158 SLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDP 217 +IL L+YIH +H D+K SNLLLN + + D+GLA EY Sbjct: 139 LYQILRGLKYIHSANVLHRDLKPSNLLLNAN--CDLKICDFGLARVTSESDFMTEYVV-- 194 Query: 218 KRCHDGTIEFTSIDAHNGVA-PSRRGDLEILGYCMIQWL 255 T + + + + + D+ +G ++ + Sbjct: 195 ------TRWYRAPELLLNSSDYTAAIDVWSVGCIFMELM 227 >3FME-A nrPDB Length = 290 Score = 124 bits (310), Expect = 8e-29, Method: Composition-based stats. Identities = 52/301 (17%), Positives = 106/301 (35%), Gaps = 45/301 (14%) Query: 42 PIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIR 101 +G+G +G + S + + V + L +L I Sbjct: 14 ELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDL--------------DIS 59 Query: 102 TRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYE---ANAKRFSRKTVLQLS 158 R + ++G+ + + ++ M+ + L K Y+ + + +++ Sbjct: 60 MRTVDCPFTVTFYGALFREGD----VWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIA 115 Query: 159 LRILDILEYIHEH-EYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDP 217 + I+ LE++H +H D+K SN+L+N QV + D+G++ + V K+ Sbjct: 116 VSIVKALEHLHSKLSVIHRDVKPSNVLINA--LGQVKMCDFGISGYLVDD-VAKDID--- 169 Query: 218 KRCHDGTIEFTSIDAHNG----VAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRD 273 G + + + N S + D+ LG MI+ P+ D+ P Sbjct: 170 ----AGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPY-DSWGTPFQQ-- 222 Query: 274 SKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLY-ENLRDILLQGLKAIG 332 K E L P E + + E+P Y E ++ ++ G Sbjct: 223 LKQVVEEPSPQL-----PADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKG 277 Query: 333 S 333 + Sbjct: 278 T 278 >4JDH-A nrPDB Length = 346 Score = 124 bits (310), Expect = 8e-29, Method: Composition-based stats. Identities = 50/280 (17%), Positives = 101/280 (36%), Gaps = 35/280 (12%) Query: 1 MPRVKAAQAGRQSSAKRHLAEQF-AVGEIITDMAKKEWKVGL--PIGQGGFGCIYLADMN 57 MP Q +R EQF A +++ D + IG+G G + +A + Sbjct: 37 MPEKPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVR 96 Query: 58 SSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSG 117 SS V K++ ++ + + + R ++ V + + S Sbjct: 97 SS----GKLVAVKKMD------------LRKQQRRELLFNEVVIMRDYQHENVVEMYNSY 140 Query: 118 LHDKNGKSYRFMIMDRF-GSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHG 176 L +++M+ G L I R + + + + L +L L +H +H Sbjct: 141 LVGDE----LWVVMEFLEGGALTDIV--THTRMNEEQIAAVCLAVLQALSVLHAQGVIHR 194 Query: 177 DIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGV 236 DIK+ ++LL + +V L D+G + E ++ GT + + + + + Sbjct: 195 DIKSDSILLTHDG--RVKLSDFGFCAQVSKEV-------PRRKSLVGTPYWMAPELISRL 245 Query: 237 APSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKI 276 D+ LG +I+ + G P+ + Sbjct: 246 PYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDN 285 >3MIA-A nrPDB Length = 351 Score = 124 bits (310), Expect = 8e-29, Method: Composition-based stats. Identities = 41/234 (17%), Positives = 82/234 (35%), Gaps = 18/234 (7%) Query: 36 EWKVGLPIGQGGFGCIYLADMN-SSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPE 94 +++ IGQG FG ++ A + + V + + E+K Q Sbjct: 18 KYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHEN 77 Query: 95 QIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTV 154 + R K +++ D DL + +F+ + Sbjct: 78 VVNLIEICRTKASPY-----------NRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEI 126 Query: 155 LQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYK 214 ++ +L+ L YIH ++ +H D+KA+N+L+ + L D+GLA + + + Sbjct: 127 KRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDG--VLKLADFGLARAFSLAKNSQPNR 184 Query: 215 EDPKRCHDGTIEFTSIDAHNG-VAPSRRGDLEILGYCMIQWLTGHLPWEDNLKD 267 + T+ + + G DL G M + T + N + Sbjct: 185 YTNRVV---TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQ 235 >4MYG-A nrPDB Length = 372 Score = 124 bits (310), Expect = 8e-29, Method: Composition-based stats. Identities = 50/271 (18%), Positives = 102/271 (37%), Gaps = 40/271 (14%) Query: 16 KRHLAEQFAVGEIITDMAKKEWKVGLP------IGQGGFGCIYLA-DMNSSESVGSDAPC 68 H++ G D+ K W++ +G G +G + A D S E V Sbjct: 18 GSHMSLIRKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIK--- 74 Query: 69 VVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYR- 127 K+ +F + + ++ + + +++ V + +++ Sbjct: 75 --KLSRPFQSEIFAKRAY----------RELLLLKHMQHENVIGLLDVFTPASSLRNFYD 122 Query: 128 -FMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLN 186 +++M +DLQKI FS + + L ++L L+YIH VH D+K NL +N Sbjct: 123 FYLVMPFMQTDLQKIM---GMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVN 179 Query: 187 YKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRR-GDLE 245 ++ ++D+GLA E + T + + + + D+ Sbjct: 180 ED--CELKILDFGLARHADAEMT----------GYVVTRWYRAPEVILSWMHYNQTVDIW 227 Query: 246 ILGYCMIQWLTGHLPWEDNLKDPKYVRDSKI 276 +G M + LTG ++ + + K+ Sbjct: 228 SVGCIMAEMLTGKTLFKGKDYLDQLTQILKV 258 >3LM0-A nrPDB Length = 327 Score = 124 bits (310), Expect = 8e-29, Method: Composition-based stats. Identities = 46/294 (15%), Positives = 100/294 (34%), Gaps = 43/294 (14%) Query: 41 LPIGQGGFGCIYLADMN-SSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKW 99 +G+G F + + + + + + E+ + A ++ Sbjct: 35 KELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELAKSCPRVINL 94 Query: 100 IRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRF----SRKTVL 155 + S +I++ +I+ S V+ Sbjct: 95 HEVYE------------------NTSEIILILEYAAGG--EIFSLCLPELAEMVSENDVI 134 Query: 156 QLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNP-DQVYLVDYGLAYRYCPEGVHKEYK 214 +L +IL+ + Y+H++ VH D+K N+LL+ P + +VD+G++ + +E Sbjct: 135 RLIKQILEGVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACELREIM 194 Query: 215 EDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDS 274 GT E+ + + N + D+ +G LT P+ Y+ S Sbjct: 195 --------GTPEYLAPEILNYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNIS 246 Query: 275 KIR--YRENIASLMDKCFPE------KNKPGEIAKYMETVKLLDYTEKPLYENL 320 ++ Y E S + + + P + E + ++ +ENL Sbjct: 247 QVNVDYSEETFSSVSQLATDFIQSLLVKNPEKRPT-AEICLSHSWLQQWDFENL 299 >6CKI-A nrPDB Length = 316 Score = 124 bits (310), Expect = 9e-29, Method: Composition-based stats. Identities = 32/238 (13%), Positives = 77/238 (32%), Gaps = 20/238 (8%) Query: 30 TDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQR 89 TD ++ + + G A + + ++ + VK+ G + Sbjct: 3 TDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHI--------- 53 Query: 90 AAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRF 149 + + + L + + + +++ ++ + + F Sbjct: 54 -----RSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHF 108 Query: 150 SRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNP-DQVYLVDYGLAYRYCPEG 208 + + + L+++H H D+K N+L + N V + D+GL G Sbjct: 109 NELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNG 168 Query: 209 VHKEYKEDPKRCHDGTIEFTSIDAHNGVA-----PSRRGDLEILGYCMIQWLTGHLPW 261 G+ E+ + + + +R DL LG + L+G+ P+ Sbjct: 169 DCSPISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPF 226 >4TNB-A nrPDB Length = 590 Score = 124 bits (310), Expect = 9e-29, Method: Composition-based stats. Identities = 41/250 (16%), Positives = 84/250 (33%), Gaps = 25/250 (10%) Query: 32 MAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAA 91 + K ++ +G+GGFG + + ++ + + K + +R Sbjct: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKK-------------RIKKRKG 227 Query: 92 KPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSR 151 + + + K+ V + + + + G IY F Sbjct: 228 ESMALNEKQILEKVNSQFVVNLAYAY--ETKDALCLVLTIMNGGDLKFHIYNMGNPGFEE 285 Query: 152 KTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHK 211 + L + IL LE +H V+ D+K N+LL+ + + + D GLA + Sbjct: 286 ERALFYAAEILCGLEDLHHENTVYRDLKPENILLD--DYGHIRISDLGLAVKIP------ 337 Query: 212 EYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYV 271 + D R GT+ + + + N D LG + + + G P+ + K Sbjct: 338 --EGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKRE 395 Query: 272 RDSKIRYREN 281 + Sbjct: 396 EVDRRVLETE 405 >3ZDU-A nrPDB Length = 325 Score = 124 bits (310), Expect = 9e-29, Method: Composition-based stats. Identities = 35/229 (15%), Positives = 80/229 (34%), Gaps = 31/229 (13%) Query: 33 AKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAK 92 + + ++ +G+G +G + ++ + + + E S N E+KF ++ Sbjct: 1 SMEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQFHH 60 Query: 93 PEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFG-SDLQKIYEANAKRFSR 151 + R+ K ++ + + L ++ Sbjct: 61 ENLVNLIEVFRQ-------------------KKKIHLVFEFIDHTVLDELQHYCHG-LES 100 Query: 152 KTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHK 211 K + + +IL ++Y+H + +H DIK N+L++ L D+G A Sbjct: 101 KRLRKYLFQILRAIDYLHSNNIIHRDIKPENILVSQSGIT--KLCDFGFARTLA------ 152 Query: 212 EYKEDPKRCHDGTIEFTSIDAHNGV-APSRRGDLEILGYCMIQWLTGHL 259 D T + + + + + D+ LG +I+ TG+ Sbjct: 153 -APGDIYDDEVATRWYRAPELVLKDTSYGKPVDIWALGCMIIEMATGNP 200 >5Y86-A nrPDB Length = 588 Score = 123 bits (309), Expect = 9e-29, Method: Composition-based stats. Identities = 46/261 (17%), Positives = 100/261 (38%), Gaps = 30/261 (11%) Query: 6 AAQAGRQSSAKRHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSD 65 G + + A + D ++V IG+G FG + A + + Sbjct: 180 GVIGGP--NNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQV--ARVYDHKLRQYV 235 Query: 66 APCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKS 125 A +V+ E + E++ + ++K +T + + + + + H Sbjct: 236 ALKMVRNEKRFHRQAAEEIRILE------HLKKQDKTGSMNVIHMLESFTFRNH------ 283 Query: 126 YRFMIMDRFGSDLQKIYEANA-KRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLL 184 M + DL ++ + N + FS + V + + IL L+ +H+++ +H D+K N+L Sbjct: 284 -VCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENIL 342 Query: 185 LNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDL 244 L + ++D+G + ++ + + + + + G S D+ Sbjct: 343 LKHHGRSSTKVIDFGSS----------CFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDI 392 Query: 245 EILGYCMIQWLTGHL--PWED 263 G + + LTG P ED Sbjct: 393 WSFGCILAELLTGQPLFPGED 413 >4M7I-A nrPDB Length = 299 Score = 123 bits (309), Expect = 1e-28, Method: Composition-based stats. Identities = 48/273 (17%), Positives = 100/273 (36%), Gaps = 44/273 (16%) Query: 43 IGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRT 102 +G+GGFG ++ A ++ D +K N L E + +++ Sbjct: 13 LGRGGFGVVFEA-----KNKVDDCNYAIKRIRLPNRELARE----------KVMREVKAL 57 Query: 103 RKLKYLGVPKYWGSGLHDKNG--------KSYRFMIMDRFGSDLQKIYEANAKRFSRKTV 154 KL++ G+ +Y+ + L K Y ++ M + K + + Sbjct: 58 AKLEHPGIVRYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERER 117 Query: 155 ---LQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHK 211 L + L+I + +E++H +H D+K SN+ + V + D+GL + + Sbjct: 118 SVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDD--VVKVGDFGLVTAMDQDEEEQ 175 Query: 212 EYK-----EDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLK 266 GT + S + +G + S + D+ LG + + L P+ Sbjct: 176 TVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLY---PFST--- 229 Query: 267 DPKYVRDSKIRYRENIASLMDKCFPEKNKPGEI 299 + ++R ++ +L + P E Sbjct: 230 -----QMERVRTLTDVRNLKFPPLFTQKYPCEY 257 >4KS7-A nrPDB Length = 292 Score = 123 bits (309), Expect = 1e-28, Method: Composition-based stats. Identities = 45/268 (16%), Positives = 98/268 (36%), Gaps = 39/268 (14%) Query: 42 PIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIR 101 IG+G G + LA S VK+ + ++ + + + Sbjct: 30 KIGEGSTGIVCLAREK-----HSGRQVAVKM-----------MDLRKQQRRELLFNEVVI 73 Query: 102 TRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYEANAKRFSRKTVLQLSLR 160 R ++ V + + S L + +++M+ G L I + R + + + + Sbjct: 74 MRDYQHFNVVEMYKSYLVGEE----LWVLMEFLQGGALTDIV--SQVRLNEEQIATVCEA 127 Query: 161 ILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRC 220 +L L Y+H +H DIK+ ++LL +V L D+G + + ++ Sbjct: 128 VLQALAYLHAQGVIHRDIKSDSILLTLDG--RVKLSDFGFCAQISKDV-------PKRKS 178 Query: 221 HDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPW-----EDNLKDPKYVRDSK 275 GT + + + + + D+ LG +I+ + G P+ +K + K Sbjct: 179 LVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPK 238 Query: 276 IRYRENIASLMD--KCFPEKNKPGEIAK 301 ++ ++ ++ P E A Sbjct: 239 LKNSHKVSPVLRDFLERMLVRDPQERAT 266 >6DBN-A nrPDB Length = 316 Score = 123 bits (309), Expect = 1e-28, Method: Composition-based stats. Identities = 61/323 (18%), Positives = 123/323 (38%), Gaps = 30/323 (9%) Query: 16 KRHLAEQFAVGEIITDMAKKEW-KVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEP 74 ++E+ E+ +K + K +G+G FG + L + + V ++P Sbjct: 15 PDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKP 74 Query: 75 SDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF 134 G +LK ++ R L + + KY G + ++G + +IM+ Sbjct: 75 ESGGNHIADLK-----------KEIEILRNLYHENIVKYKG--ICTEDGGNGIKLIMEFL 121 Query: 135 -GSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQV 193 L++ N + + K L+ +++I ++Y+ +YVH D+ A N+L+ + QV Sbjct: 122 PSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESE--HQV 179 Query: 194 YLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQ 253 + D+GL + + K+D + + + D+ G + + Sbjct: 180 KIGDFGLTKAIETDKEYYTVKDDRDSPVF----WYAPECLMQSKFYIASDVWSFGVTLHE 235 Query: 254 WLT----GHLPWEDNLK--DPKYVRDSKIRYRENI-ASLMDKCFPEKNKPGEIAKYMETV 306 LT P LK P + + + R + C P N P E+ + M Sbjct: 236 LLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPP--NCPDEVYQLMRKC 293 Query: 307 KLLDYTEKPLYENLRDILLQGLK 329 + + ++NL + LK Sbjct: 294 WEFQPSNRTSFQNLIEGFEALLK 316 >5TUR-A nrPDB Length = 404 Score = 123 bits (309), Expect = 1e-28, Method: Composition-based stats. Identities = 48/288 (16%), Positives = 99/288 (34%), Gaps = 25/288 (8%) Query: 20 AEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGP 79 A + A G+ + +++VG +G GGFG +Y S V + P +K D Sbjct: 113 ATKLAPGKEKEPLES-QYQVGPLLGSGGFGSVY-----SGIRVSDNLPVAIKHVEKDRIS 166 Query: 80 LFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQ 139 + EL R + K + + + + ++ ++ + DL Sbjct: 167 DWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWF-----ERPDSFVLILERPEPVQDLF 221 Query: 140 KIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYG 199 + ++L+ + + H +H DIK N+L++ N ++ L+D+G Sbjct: 222 DFI-TERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDL-NRGELKLIDFG 279 Query: 200 LAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNG-VAPSRRGDLEILGYCMIQWLTGH 258 DGT ++ + R + LG + + G Sbjct: 280 SGALLKDTV---------YTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGD 330 Query: 259 LPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETV 306 +P+E + + + + R L+ C +P + + E Sbjct: 331 IPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLAL--RPSDRPTFEEIQ 376 >3BGP-A nrPDB Length = 333 Score = 123 bits (309), Expect = 1e-28, Method: Composition-based stats. Identities = 48/288 (16%), Positives = 99/288 (34%), Gaps = 25/288 (8%) Query: 20 AEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGP 79 A + A G+ + +++VG +G GGFG +Y S V + P +K D Sbjct: 42 ATKLAPGKEKEPLES-QYQVGPLLGSGGFGSVY-----SGIRVSDNLPVAIKHVEKDRIS 95 Query: 80 LFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQ 139 + EL R + K + + + + ++ ++ + DL Sbjct: 96 DWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWF-----ERPDSFVLILERPEPVQDLF 150 Query: 140 KIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYG 199 + ++L+ + + H +H DIK N+L++ N ++ L+D+G Sbjct: 151 DFI-TERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDL-NRGELKLIDFG 208 Query: 200 LAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNG-VAPSRRGDLEILGYCMIQWLTGH 258 DGT ++ + R + LG + + G Sbjct: 209 SGALLKDTV---------YTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGD 259 Query: 259 LPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETV 306 +P+E + + + + R L+ C +P + + E Sbjct: 260 IPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLAL--RPSDRPTFEEIQ 305 >4EWQ-A nrPDB Length = 383 Score = 123 bits (309), Expect = 1e-28, Method: Composition-based stats. Identities = 43/242 (17%), Positives = 91/242 (37%), Gaps = 29/242 (11%) Query: 33 AKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAK 92 + ++ P+G G +G + A + VK + + Y+ Sbjct: 43 VPERYQNLSPVGSGAYGSVCAAFDTKT-----GLRVAVKKLSRPFQSIIHAKRTYR---- 93 Query: 93 PEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRK 152 +++ + +G+ + + +++ G+DL I + ++ + Sbjct: 94 --ELRLLKHMKHENVIGLLDVFTPA-RSLEEFNDVYLVTHLMGADLNNIVKC--QKLTDD 148 Query: 153 TVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKE 212 V L +IL L+YIH + +H D+K SNL +N ++ ++D+GLA E Sbjct: 149 HVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNED--CELKILDFGLARHTDDEMT--- 203 Query: 213 YKEDPKRCHDGTIEFTSIDAHNGVAPSRR-GDLEILGYCMIQWLTGH--LPWEDNLKDPK 269 + T + + + + D+ +G M + LTG P D++ K Sbjct: 204 -------GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLK 256 Query: 270 YV 271 + Sbjct: 257 LI 258 >4FIE-A nrPDB Length = 423 Score = 123 bits (308), Expect = 1e-28, Method: Composition-based stats. Identities = 50/280 (17%), Positives = 101/280 (36%), Gaps = 35/280 (12%) Query: 1 MPRVKAAQAGRQSSAKRHLAEQF-AVGEIITDMAKKEWKVGL--PIGQGGFGCIYLADMN 57 MP Q +R EQF A +++ D + IG+G G + +A + Sbjct: 114 MPEKPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVR 173 Query: 58 SSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSG 117 SS V K++ ++ + + + R ++ V + + S Sbjct: 174 SS----GKLVAVKKMD------------LRKQQRRELLFNEVVIMRDYQHENVVEMYNSY 217 Query: 118 LHDKNGKSYRFMIMDRF-GSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHG 176 L +++M+ G L I R + + + + L +L L +H +H Sbjct: 218 LVGDE----LWVVMEFLEGGALTDIV--THTRMNEEQIAAVCLAVLQALSVLHAQGVIHR 271 Query: 177 DIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGV 236 DIK+ ++LL + +V L D+G + E ++ GT + + + + + Sbjct: 272 DIKSDSILLTHDG--RVKLSDFGFCAQVSKEV-------PRRKSLVGTPYWMAPELISRL 322 Query: 237 APSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKI 276 D+ LG +I+ + G P+ + Sbjct: 323 PYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDN 362 >4XBR-A nrPDB Length = 366 Score = 123 bits (308), Expect = 1e-28, Method: Composition-based stats. Identities = 41/236 (17%), Positives = 87/236 (36%), Gaps = 32/236 (13%) Query: 42 PIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIR 101 IG+G G + +A + SS V K++ ++ + + + Sbjct: 101 KIGEGSTGIVCIATVRSS----GKLVAVKKMD------------LRKQQRRELLFNEVVI 144 Query: 102 TRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYEANAKRFSRKTVLQLSLR 160 R ++ V + + S L +++M+ G L I R + + + + L Sbjct: 145 MRDYQHENVVEMYNSYLVGDE----LWVVMEFLEGGALTDIV--THTRMNEEQIAAVCLA 198 Query: 161 ILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRC 220 +L L +H +H DIK+ ++LL + +V L D+G + E ++ Sbjct: 199 VLQALSVLHAQGVIHRDIKSDSILLTHDG--RVKLSDFGFCAQVSKEV-------PRRKS 249 Query: 221 HDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKI 276 GT + + + + + D+ LG +I+ + G P+ + Sbjct: 250 LVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDN 305 >2Q0N-A nrPDB Length = 301 Score = 123 bits (308), Expect = 1e-28, Method: Composition-based stats. Identities = 41/236 (17%), Positives = 87/236 (36%), Gaps = 32/236 (13%) Query: 42 PIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIR 101 IG+G G + +A + SS V K++ ++ + + + Sbjct: 36 KIGEGSTGIVCIATVRSS----GKLVAVKKMD------------LRKQQRRELLFNEVVI 79 Query: 102 TRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYEANAKRFSRKTVLQLSLR 160 R ++ V + + S L +++M+ G L I R + + + + L Sbjct: 80 MRDYQHENVVEMYNSYLVGDE----LWVVMEFLEGGALTDIV--THTRMNEEQIAAVCLA 133 Query: 161 ILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRC 220 +L L +H +H DIK+ ++LL + +V L D+G + E ++ Sbjct: 134 VLQALSVLHAQGVIHRDIKSDSILLTHDG--RVKLSDFGFCAQVSKEV-------PRRKS 184 Query: 221 HDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKI 276 GT + + + + + D+ LG +I+ + G P+ + Sbjct: 185 LVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDN 240 >3OHT-A nrPDB Length = 389 Score = 123 bits (307), Expect = 2e-28, Method: Composition-based stats. Identities = 44/273 (16%), Positives = 98/273 (35%), Gaps = 34/273 (12%) Query: 9 AGRQSSA--KRHLAEQFAVGEIITDM---AKKEWKVGLPIGQGGFGCIYLADMNSSESVG 63 AG ++ H + + + ++ P+G G +G + +S + Sbjct: 20 AGSAAAPFTMSHKERPTFYRQELNKTIWEVPERYQTLSPVGSGAYGSV----CSSYDVKS 75 Query: 64 SDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNG 123 V K+ + + + +++ + +G+ + Sbjct: 76 GLKIAVKKLSRPFQSIIHAKRTY-------RELRLLKHMKHENVIGLLDVFTPATS-LEE 127 Query: 124 KSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNL 183 + +++ G+DL I + ++ + V L +IL L+YIH + +H D+K SNL Sbjct: 128 FNDVYLVTHLMGADLNNIVKC--QKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNL 185 Query: 184 LLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPS-RRG 242 +N ++ ++D+GLA E + T + + + Sbjct: 186 AVNED--CELKILDFGLARHTDDEMT----------GYVATRWYRAPEIMLNWMHYNMTV 233 Query: 243 DLEILGYCMIQWLTGH--LPWEDNLKDPKYVRD 273 D+ +G M + LTG P D++ + + Sbjct: 234 DIWSVGCIMAELLTGRTLFPGTDHINQLQQIMR 266 >2W96-B nrPDB Length = 306 Score = 123 bits (307), Expect = 2e-28, Method: Composition-based stats. Identities = 40/247 (16%), Positives = 82/247 (33%), Gaps = 25/247 (10%) Query: 32 MAKKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRA 90 MA ++ IG G +G +Y A D +S V + V E E+ +R Sbjct: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPISTVREVALLRRL 60 Query: 91 AKPEQIQKWIRTRKLKYLGVPKYWG-SGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKR- 148 ++ V + + + ++ + DL+ + Sbjct: 61 ------------EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPG 108 Query: 149 FSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEG 208 +T+ L + L L+++H + VH D+K N+L+ V L D+GLA Y + Sbjct: 109 LPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGT--VKLADFGLARIYSYQM 166 Query: 209 VHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDP 268 T+ + + + + D+ +G + + N + Sbjct: 167 ALDPVVV--------TLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEAD 218 Query: 269 KYVRDSK 275 + + Sbjct: 219 QLGKIFD 225 >4QNY-A nrPDB Length = 354 Score = 123 bits (307), Expect = 2e-28, Method: Composition-based stats. Identities = 52/350 (14%), Positives = 121/350 (34%), Gaps = 40/350 (11%) Query: 35 KEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPE 94 + + IG G +G + A S++ V K +F E+ +R + Sbjct: 20 DRYLLERIIGAGSYGVVIRARDTKSDNRLVAMKRVNK-------EIFEEVILAKRILREI 72 Query: 95 QIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTV 154 ++ + +G+ D + +++MD +DL+++ + + + + Sbjct: 73 KLLAHFNDDNI--IGLRNIL--TPEDPENFDHFYIVMDIMETDLKQVL-RSGQELTEAHI 127 Query: 155 LQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYK 214 + L L IH +H DI +N+L+N + + D+GLA +G + Sbjct: 128 QFFIYQALRALHIIHSAGVIHRDITPANILVNTN--CDLKICDFGLAKEENDQGEYMT-D 184 Query: 215 EDPKRCHDGTIEFTSIDAHNG-VAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRD 273 R + + + S + D+ +G + + L ++ + + + Sbjct: 185 YVTMRW------YRAPELVMEDKDYSAQIDVWGIGCILGELLGSRPLFQGKDRVNQLDKI 238 Query: 274 SK--IRYRENIASLMDKCFPEK---------------NKPGEIAKYMETVK-LLDYTEKP 315 E + + +K P + ++ ++ +L + K Sbjct: 239 VDVIGTPSEEDINSVGSSAAQKYLKKKSHRPQADWRQRYPTASPEALDLLRHMLVFNPKR 298 Query: 316 LYENLRDILLQGLKAIGSKDDGKLDLSVVENGGLKAKTITKKRKKEIEES 365 L+ + L+ + D L ++ + KTI ++ EES Sbjct: 299 RITVLQAMRHPFLEQLHDDADDNLSYALFRFDENEQKTIVDVKRAIYEES 348 >1U59-A nrPDB Length = 287 Score = 123 bits (307), Expect = 2e-28, Method: Composition-based stats. Identities = 52/298 (17%), Positives = 110/298 (36%), Gaps = 36/298 (12%) Query: 42 PIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIR 101 +G G FG + + A V+K + ++A E +++ Sbjct: 17 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLK-------------QGTEKADTEEMMREAQI 63 Query: 102 TRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSD-LQKIYEANAKRFSRKTVLQLSLR 160 +L + + G ++M+ G L K + V +L + Sbjct: 64 MHQLDNPYIVRLIGV-----CQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQ 118 Query: 161 ILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRC 220 + ++Y+ E +VH D+ A N+LL + + D+GL+ + + + K Sbjct: 119 VSMGMKYLEEKNFVHRDLAARNVLLVNR--HYAKISDFGLSKALGADDSYYTARSAGKW- 175 Query: 221 HDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWL-TGHLPWEDNLKDPKYVRDSKIRYR 279 +++ + + N S R D+ G M + L G P++ +K P+ + + R Sbjct: 176 ---PLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYK-KMKGPEVMAFIEQGKR 231 Query: 280 ENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDILLQGLKAIGSKDDG 337 +C PE P E+ M + + ++P + + + ++ SK +G Sbjct: 232 -------MECPPE--CPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEG 280 >1JNK-A nrPDB Length = 423 Score = 123 bits (307), Expect = 2e-28, Method: Composition-based stats. Identities = 44/304 (14%), Positives = 106/304 (34%), Gaps = 37/304 (12%) Query: 6 AAQAGRQSSAKRHLAEQFAVGEI--ITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVG 63 + A + +K + QF E+ T K ++ PIG G G + + ++V Sbjct: 31 SYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIV----CAAYDAVL 86 Query: 64 SDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDK-- 121 + K+ + + ++ + + + + + K Sbjct: 87 DRNVAIKKLSRPFQNQTHAKRAY----------RELVLMKCVNHKNIISLLNVFTPQKTL 136 Query: 122 NGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKAS 181 +++M+ ++L ++ + + + L ++L ++++H +H D+K S Sbjct: 137 EEFQDVYLVMELMDANLCQVIQMELDH---ERMSYLLYQMLCGIKHLHSAGIIHRDLKPS 193 Query: 182 NLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRR 241 N+++ K+ + ++D+GLA + Y + + + G+ Sbjct: 194 NIVV--KSDCTLKILDFGLARTAGTSFMMTPYVVTRY--------YRAPEVILGMGYKEN 243 Query: 242 GDLEILGYCMIQWLTGHL--PWEDNLKDPKYVRDSKIRYRENIASLMDKCFPE-KNKPGE 298 D+ +G M + + + P D + V + M K P +N Sbjct: 244 VDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVI---EQLGTPCPEFMKKLQPTVRNYVEN 300 Query: 299 IAKY 302 KY Sbjct: 301 RPKY 304 >4PWN-A nrPDB Length = 274 Score = 123 bits (307), Expect = 2e-28, Method: Composition-based stats. Identities = 44/235 (18%), Positives = 82/235 (34%), Gaps = 28/235 (11%) Query: 42 PIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWI 100 IG+G F +Y D ++ V K+ S+ E + + Sbjct: 17 EIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLK------------ 64 Query: 101 RTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLR 160 L++ + +++ S GK ++ + S K Y K K + + Sbjct: 65 ---GLQHPNIVRFYDSWESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQ 121 Query: 161 ILDILEYIHEHE--YVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPK 218 IL L+++H +H D+K N+ + V + D GLA E + Sbjct: 122 ILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGS-VKIGDLGLATL--------EKRASFA 172 Query: 219 RCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRD 273 + GT EF + + + D+ G CM++ T P+ + + R Sbjct: 173 KSVIGTPEFMAPEMYEEKY-DESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRR 226 >5AIR-A nrPDB Length = 430 Score = 122 bits (305), Expect = 3e-28, Method: Composition-based stats. Identities = 42/244 (17%), Positives = 80/244 (32%), Gaps = 31/244 (12%) Query: 37 WKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQI 96 + IG G FG +Y A + S +K D EL+ ++ + Sbjct: 66 YTDTKVIGNGSFGVVYQA-----KLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIV 120 Query: 97 QKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKI---YEANAKRFSRKT 153 + +Y+ +K + Y +++D + ++ Y + Sbjct: 121 R-------------LRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIY 167 Query: 154 VLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEY 213 V ++ L YIH H DIK NLLL+ + + L D+G A + + Y Sbjct: 168 VKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDP-DTAVLKLCDFGSAKQLVRGEPNVSY 226 Query: 214 KEDPKRCHDGTIEFTSIDAHNGVAPSRRG-DLEILGYCMIQWLTGHLPWEDNLKDPKYVR 272 + + + G D+ G + + L G + + + V Sbjct: 227 ICSRY--------YRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVE 278 Query: 273 DSKI 276 K+ Sbjct: 279 IIKV 282 >4H1J-A nrPDB Length = 293 Score = 122 bits (305), Expect = 3e-28, Method: Composition-based stats. Identities = 58/282 (20%), Positives = 107/282 (37%), Gaps = 38/282 (13%) Query: 39 VGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQK 98 + +G+G FG +Y + + G VK D L + KF A Sbjct: 28 LNRILGEGFFGEVYEGVYTNHK--GEKINVAVKTCKKDC-TLDNKEKFMSEA-------- 76 Query: 99 WIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFG-SDLQKIYEANAKRFSRKTVLQL 157 + + L + + K G + ++IM+ + +L E N T++ Sbjct: 77 -VIMKNLDHPHIVKLIGIIEEEPT-----WIIMELYPYGELGHYLERNKNSLKVLTLVLY 130 Query: 158 SLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDP 217 SL+I + Y+ VH DI N+L+ P+ V L D+GL+ E +K Sbjct: 131 SLQICKAMAYLESINCVHRDIAVRNILVAS--PECVKLGDFGLSRYIEDEDYYKASVTRL 188 Query: 218 KRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT-GHLPWEDNLKDPKYVRDSKI 276 I++ S ++ N + D+ + CM + L+ G P+ L++ + + Sbjct: 189 ------PIKWMSPESINFRRFTTASDVWMFAVCMWEILSFGKQPFF-WLENKDVIGVLEK 241 Query: 277 RYREN--------IASLMDKCFPEKNKPGEIAKYMETVKLLD 310 R + +LM +C+ P + ++ E V L Sbjct: 242 GDRLPKPDLCPPVLYTLMTRCWDYD--PSDRPRFTELVCSLS 281 >3AOX-A nrPDB Length = 344 Score = 122 bits (305), Expect = 3e-28, Method: Composition-based stats. Identities = 47/305 (15%), Positives = 113/305 (37%), Gaps = 38/305 (12%) Query: 29 ITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQ 88 + ++ +K + +G G FG +Y ++ + S VK P Sbjct: 41 LKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPE----------VCS 90 Query: 89 RAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYEANAK 147 + + + + + K + + + G L RF++++ G DL+ Sbjct: 91 EQDELDFLMEALIISKFNHQNIVRCIGVSLQSLP----RFILLELMAGGDLKSFLRETRP 146 Query: 148 R------FSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQV-YLVDYGL 200 R + +L ++ I +Y+ E+ ++H DI A N LL P +V + D+G+ Sbjct: 147 RPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGM 206 Query: 201 AYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT-GHL 259 A +++ C +++ +A + + D G + + + G++ Sbjct: 207 AR-----DIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYM 261 Query: 260 PWEDNLKDPKYVRDSKIRYRENI-------ASLMDKCFPEKNKPGEIAKYMETVKLLDY- 311 P+ + + +M +C+ +++P + + ++ ++Y Sbjct: 262 PYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCW--QHQPEDRPNFAIILERIEYC 319 Query: 312 TEKPL 316 T+ P Sbjct: 320 TQDPD 324 >6GVJ-A nrPDB Length = 429 Score = 122 bits (305), Expect = 4e-28, Method: Composition-based stats. Identities = 38/243 (15%), Positives = 82/243 (33%), Gaps = 37/243 (15%) Query: 32 MAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAA 91 + + + + IG GG ++ + + + + E+ + + Sbjct: 141 VKGRIYSILKQIGSGGSSKVFQVLNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQ 200 Query: 92 KPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSR 151 + + + + + D Y +M+M+ DL + K Sbjct: 201 Q-------------HSDKIIRLYDYEITD----QYIYMVMECGNIDLNSWLKKK-KSIDP 242 Query: 152 KTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHK 211 +L+ + IH+H VH D+K +N L+ + L+D+G+A + P+ Sbjct: 243 WERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVD---GMLKLIDFGIANQMQPDTTSV 299 Query: 212 EYKEDPKRCHDGTIEFTSIDAHNGVAPSRR-----------GDLEILGYCMIQWLTGHLP 260 K GT+ + +A ++ SR D+ LG + G P Sbjct: 300 -----VKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTP 354 Query: 261 WED 263 ++ Sbjct: 355 FQQ 357 >2XS0-A nrPDB Length = 386 Score = 121 bits (304), Expect = 4e-28, Method: Composition-based stats. Identities = 61/410 (14%), Positives = 134/410 (32%), Gaps = 62/410 (15%) Query: 10 GRQSSAKRHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCV 69 G S +KR T K ++ PIG G G + + +++ + Sbjct: 1 GSMSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIV----CAAYDAILERNVAI 56 Query: 70 VKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDK--NGKSYR 127 K+ + + ++ + + + + + K Sbjct: 57 KKLSRPFQNQTHAKRAY----------RELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDV 106 Query: 128 FMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY 187 +++M+ ++L ++ + + + L ++L ++++H +H D+K SN+++ Sbjct: 107 YIVMELMDANLCQVIQMELDH---ERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVV-- 161 Query: 188 KNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEIL 247 K+ + ++D+GLA + + + + + G+ D+ + Sbjct: 162 KSDCTLKILDFGLARTAGTSFMMVPFVVTRY--------YRAPEVILGMGYKENVDIWSV 213 Query: 248 GYCMIQWLTG--HLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPE-KNKPGEIAKYME 304 G M + + G P D++ V + M K P + KY Sbjct: 214 GCIMGEMIKGGVLFPGTDHIDQWNKVI---EQLGTPCPEFMKKLQPTVRTYVENRPKYAG 270 Query: 305 TVKLLDYTEK--PLYEN-------------LRDILLQGL-----KAIGSKDDGKLDLSVV 344 EK P RD+L + L K I + + V Sbjct: 271 YS-----FEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINV 325 Query: 345 ENGGLKAKTITKKRKKEIEESKEPGVEDTEWSNTQTEEAIQTRSRTRKRV 394 +A+ K + + +E +E EW +E + RT+ V Sbjct: 326 WYDPSEAEAPPPKIPDKQLDEREHTIE--EWKELIYKEVMDLEERTKNGV 373 >5U6B-A nrPDB Length = 307 Score = 121 bits (304), Expect = 4e-28, Method: Composition-based stats. Identities = 51/327 (15%), Positives = 116/327 (35%), Gaps = 40/327 (12%) Query: 16 KRHLAEQFAVGEIITDMAKKEWKV--GLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVE 73 L + E + D+ KV G +G+G FG + +N +S+ A +K+ Sbjct: 2 SNSLGISEELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKI- 60 Query: 74 PSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGL--HDKNGKSYRFMIM 131 R+ + + + + ++ + V + G ++ +I+ Sbjct: 61 -----------AICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVIL 109 Query: 132 DRFGSD------LQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLL 185 L + +++ I +EY+ ++H D+ A N +L Sbjct: 110 PFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCML 169 Query: 186 NYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLE 245 N V + D+GL+ + +++ + +++ +I++ + + D+ Sbjct: 170 NEN--MSVCVADFGLSKKIYNGDYYRQGRIAKM-----PVKWIAIESLADRVYTSKSDVW 222 Query: 246 ILGYCMIQWLT-GHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYME 304 G M + T G P+ Y + + A +D + ++ E Sbjct: 223 SFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWE------ 276 Query: 305 TVKLLDYTEKPLYENLRDILLQGLKAI 331 L+ ++P + LR+ L LKA+ Sbjct: 277 ----LNPQDRPSFTELREDLENTLKAL 299 >3GC0-A nrPDB Length = 329 Score = 121 bits (303), Expect = 5e-28, Method: Composition-based stats. Identities = 35/239 (14%), Positives = 84/239 (35%), Gaps = 32/239 (13%) Query: 31 DMAKKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQR 89 + ++ +G+G +G +Y A D ++E+V + E G E+ + Sbjct: 30 ATSIDRYRRITKLGEGTYGEVYKAIDTVTNETVAIKRIRLEHEEEGVPGTAIREVSLLKE 89 Query: 90 AAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRF 149 + I + + + +I + +DL+K + N Sbjct: 90 LQH----RNIIELKSVIHHNH---------------RLHLIFEYAENDLKKYMDKNPD-V 129 Query: 150 SRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQ---VYLVDYGLAYRYCP 206 S + + ++++ + + H +H D+K NLLL+ + + + + D+GLA + Sbjct: 130 SMRVIKSFLYQLINGVNFCHSRRCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFG- 188 Query: 207 EGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAP-SRRGDLEILGYCMIQWLTGHLPWEDN 264 ++ T+ + + G S D+ + + L + + Sbjct: 189 ----IPIRQFTHEII--TLWYRPPEILLGSRHYSTSVDIWSIACIWAEMLMKTPLFPGD 241 >3FI2-A nrPDB Length = 353 Score = 121 bits (303), Expect = 5e-28, Method: Composition-based stats. Identities = 43/295 (14%), Positives = 103/295 (34%), Gaps = 37/295 (12%) Query: 15 AKRHLAEQFAVGEI--ITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKV 72 +K + QF E+ T K ++ PIG G G + + ++V + K+ Sbjct: 2 SKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIV----CAAYDAVLDRNVAIKKL 57 Query: 73 EPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDK--NGKSYRFMI 130 + + ++ + + + + + K +++ Sbjct: 58 SRPFQNQTHAKRAY----------RELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLV 107 Query: 131 MDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNP 190 M+ ++L ++ + + + L ++L ++++H +H D+K SN+++ K+ Sbjct: 108 MELMDANLCQVIQMELDH---ERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVV--KSD 162 Query: 191 DQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYC 250 + ++D+GLA + Y + + + G+ D+ +G Sbjct: 163 CTLKILDFGLARTAGTSFMMTPYVVTRY--------YRAPEVILGMGYKENVDIWSVGCI 214 Query: 251 MIQWLTGHL--PWEDNLKDPKYVRDSKIRYRENIASLMDKCFPE-KNKPGEIAKY 302 M + + + P D + V + M K P +N KY Sbjct: 215 MGEMVRHKILFPGRDYIDQWNKVI---EQLGTPCPEFMKKLQPTVRNYVENRPKY 266 >1CM8-A nrPDB Length = 367 Score = 121 bits (303), Expect = 6e-28, Method: Composition-based stats. Identities = 48/294 (16%), Positives = 107/294 (36%), Gaps = 54/294 (18%) Query: 37 WKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQ 95 ++ P+G G +G + A D + V F F +RA + + Sbjct: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLY----------RPFQSELFAKRAYRELR 76 Query: 96 IQKWIRTRKLKYLGVPKYWGSGLHDKNGKSY--RFMIMDRFGSDLQKIYEANAKRFSRKT 153 + + +++ V D+ + +++M G+DL K+ + ++ Sbjct: 77 L-----LKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMK--HEKLGEDR 129 Query: 154 VLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEY 213 + L ++L L YIH +H D+K NL +N ++ ++D+GLA + E Sbjct: 130 IQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNED--CELKILDFGLARQADSEMT---- 183 Query: 214 KEDPKRCHDGTIEFTSIDAHNG-VAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVR 272 + T + + + + ++ D+ +G M + +TG ++ Sbjct: 184 ------GYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKG--------- 228 Query: 273 DSKIRYRENIASLMDKCFPEKNKPGEIAKYM------ETVKLLDYTEKPLYENL 320 +++ L + P E + + +K L EK + ++ Sbjct: 229 ------SDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASI 276 >4PDO-A nrPDB Length = 299 Score = 121 bits (303), Expect = 6e-28, Method: Composition-based stats. Identities = 52/308 (16%), Positives = 107/308 (34%), Gaps = 38/308 (12%) Query: 15 AKRHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEP 74 + AV + T++ IG G FG +Y + +S + ++ Sbjct: 14 PHTYEDPNQAVLKFTTEIHPSCVTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKA 73 Query: 75 SDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF 134 Y + + + + + + + + G K +I + Sbjct: 74 G-----------YTEKQRVDFLGEAGIMGQFSHHNIIRLEGVISKYKP----MMIITEYM 118 Query: 135 -GSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQV 193 L K FS ++ + I ++Y+ YVH D+ A N+L+N Sbjct: 119 ENGALDKFLREKDGEFSVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVC-- 176 Query: 194 YLVDYGLAYRYCPEGVHKEYKEDPKRCHDG--TIEFTSIDAHNGVAPSRRGDLEILGYCM 251 + D+GL+ + E G I +T+ +A + + D+ G M Sbjct: 177 KVSDFGLSRVLEDD------PEATYTTSGGKIPIRWTAPEAISYRKFTSASDVWSFGIVM 230 Query: 252 IQWLT-GHLPWEDNLKDPKYVRDSKIRYREN--------IASLMDKCFPEKNKPGEIAKY 302 + +T G P+ + L + + ++ +R I LM +C+ ++ K+ Sbjct: 231 WEVMTYGERPYWE-LSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQQER--ARRPKF 287 Query: 303 METVKLLD 310 + V +LD Sbjct: 288 ADIVSILD 295 >3HMP-A nrPDB Length = 342 Score = 121 bits (302), Expect = 7e-28, Method: Composition-based stats. Identities = 38/243 (15%), Positives = 82/243 (33%), Gaps = 37/243 (15%) Query: 32 MAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAA 91 + + + + IG GG ++ + + + + E+ + + Sbjct: 53 VKGRIYSILKQIGSGGSSKVFQVLNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQ 112 Query: 92 KPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSR 151 + + + + + D Y +M+M+ DL + K Sbjct: 113 Q-------------HSDKIIRLYDYEITD----QYIYMVMECGNIDLNSWLKKK-KSIDP 154 Query: 152 KTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHK 211 +L+ + IH+H VH D+K +N L+ + L+D+G+A + P+ Sbjct: 155 WERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVD---GMLKLIDFGIANQMQPDTTSV 211 Query: 212 EYKEDPKRCHDGTIEFTSIDAHNGVAPSRR-----------GDLEILGYCMIQWLTGHLP 260 K GT+ + +A ++ SR D+ LG + G P Sbjct: 212 -----VKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTP 266 Query: 261 WED 263 ++ Sbjct: 267 FQQ 269 >4HVI-A nrPDB Length = 314 Score = 121 bits (302), Expect = 8e-28, Method: Composition-based stats. Identities = 47/294 (15%), Positives = 100/294 (34%), Gaps = 30/294 (10%) Query: 35 KEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPE 94 + K +G+G FG + L + A VK + + Sbjct: 10 RHLKYISQLGKGNFGSVELCR-YDPLGDNTGALVAVKQLQHSGPDQQRDFQ--------- 59 Query: 95 QIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYEANAKRFSRKT 153 ++ + L + KY G G+ ++M+ L+ + + R Sbjct: 60 --REIQILKALHSDFIVKYRGVSY--GPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASR 115 Query: 154 VLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEY 213 +L S +I +EY+ VH D+ A N+L+ + V + D+GLA + + Sbjct: 116 LLLYSSQICKGMEYLGSRRCVHRDLAARNILVESE--AHVKIADFGLAKLLPLDKDY--- 170 Query: 214 KEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRD 273 + I + + ++ + SR+ D+ G + + T + +++R Sbjct: 171 -YVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCD--KSCSPSAEFLRM 227 Query: 274 SKIRYRENIASLMDKCFPEKNK-------PGEIAKYMETVKLLDYTEKPLYENL 320 S + + E + P E+ + M+ ++P + L Sbjct: 228 MGSERDVPALSRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSAL 281 >5AP3-A nrPDB Length = 313 Score = 121 bits (302), Expect = 8e-28, Method: Composition-based stats. Identities = 38/243 (15%), Positives = 82/243 (33%), Gaps = 37/243 (15%) Query: 32 MAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAA 91 + + + + IG GG ++ + + + + E+ + + Sbjct: 25 VKGRIYSILKQIGSGGSSKVFQVLNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQ 84 Query: 92 KPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSR 151 + + + + + D Y +M+M+ DL + K Sbjct: 85 Q-------------HSDKIIRLYDYEITD----QYIYMVMECGNIDLNGWLKKK-KSIDP 126 Query: 152 KTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHK 211 +L+ + IH+H VH D+K +N L+ + L+D+G+A + P+ Sbjct: 127 WERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVD---GMLKLIDFGIANQMQPDTTSV 183 Query: 212 EYKEDPKRCHDGTIEFTSIDAHNGVAPSRR-----------GDLEILGYCMIQWLTGHLP 260 K GT+ + +A ++ SR D+ LG + G P Sbjct: 184 -----VKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTP 238 Query: 261 WED 263 ++ Sbjct: 239 FQQ 241 >4RC3-A nrPDB Length = 289 Score = 120 bits (301), Expect = 8e-28, Method: Composition-based stats. Identities = 45/272 (16%), Positives = 93/272 (34%), Gaps = 24/272 (8%) Query: 36 EWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQ 95 +++VG +G GGFG +Y S V + P +K D + EL R Sbjct: 13 QYQVGPLLGSGGFGSVY-----SGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVV 67 Query: 96 IQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVL 155 + K + + + + ++ ++ + DL + Sbjct: 68 LLKKVSSGFSGVIRLLDWF-----ERPDSFVLILERPEPVQDLFDFI-TERGALQEELAR 121 Query: 156 QLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKE 215 ++L+ + + H +H DIK N+L++ N ++ L+D+G Sbjct: 122 SFFWQVLEAVRHCHNCGVLHRDIKDENILIDL-NRGELKLIDFGSGALLKDTV------- 173 Query: 216 DPKRCHDGTIEFTSIDAHNG-VAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDS 274 DGT ++ + R + LG + + G +P+E + + + Sbjct: 174 --YTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFF 231 Query: 275 KIRYRENIASLMDKCFPEKNKPGEIAKYMETV 306 + R L+ C +P + + E Sbjct: 232 RQRVSSECQHLIRWCLAL--RPSDRPTFEEIQ 261 >3TT0-A nrPDB Length = 382 Score = 120 bits (301), Expect = 8e-28, Method: Composition-based stats. Identities = 47/294 (15%), Positives = 104/294 (35%), Gaps = 32/294 (10%) Query: 35 KEWKVGLPIGQGGFGCIYLADMN--SSESVGSDAPCVVKVEPSDN-----GPLFTELKFY 87 +G P+G+G FG + LA+ + VK+ SD L +E++ Sbjct: 69 DRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMM 128 Query: 88 QRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAK 147 + K + I + + + G ++ R L+ Y + Sbjct: 129 KMIGKHKNIINLLGACTQDGP----LYVIVEYASKGNLREYL-QARRPPGLEYSYNPSHN 183 Query: 148 R---FSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRY 204 S K ++ + ++ +EY+ + +H D+ A N+L+ N + + D+GLA Sbjct: 184 PEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDN--VMKIADFGLARDI 241 Query: 205 CPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT-GHLPWED 263 +K+ +++ + +A + + D+ G + + T G P+ Sbjct: 242 HHIDYYKKTTNGRL-----PVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPG 296 Query: 264 NLKDPKYVRDSKIRYRENI-------ASLMDKCFPEKNKPGEIAKYMETVKLLD 310 + + + + +M C+ P + + + V+ LD Sbjct: 297 VPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAV--PSQRPTFKQLVEDLD 348 >2OZO-A nrPDB Length = 613 Score = 120 bits (301), Expect = 8e-28, Method: Composition-based stats. Identities = 51/298 (17%), Positives = 110/298 (36%), Gaps = 36/298 (12%) Query: 42 PIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIR 101 +G G FG + + A V+K + ++A E +++ Sbjct: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLK-------------QGTEKADTEEMMREAQI 389 Query: 102 TRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSD-LQKIYEANAKRFSRKTVLQLSLR 160 +L + + G ++M+ G L K + V +L + Sbjct: 390 MHQLDNPYIVRLIGV-----CQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQ 444 Query: 161 ILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRC 220 + ++Y+ E +VH ++ A N+LL + + D+GL+ + + + K Sbjct: 445 VSMGMKYLEEKNFVHRNLAARNVLLVNR--HYAKISDFGLSKALGADDSYYTARSAGKW- 501 Query: 221 HDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWL-TGHLPWEDNLKDPKYVRDSKIRYR 279 +++ + + N S R D+ G M + L G P++ +K P+ + + R Sbjct: 502 ---PLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYK-KMKGPEVMAFIEQGKR 557 Query: 280 ENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDILLQGLKAIGSKDDG 337 +C PE P E+ M + + ++P + + + ++ SK +G Sbjct: 558 -------MECPPE--CPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEG 606 >5O2B-A nrPDB Length = 285 Score = 120 bits (301), Expect = 8e-28, Method: Composition-based stats. Identities = 43/249 (17%), Positives = 86/249 (34%), Gaps = 29/249 (11%) Query: 28 IITDMAKKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKF 86 + T + + K + +G+G F +Y D + V K+ ++ E + Sbjct: 9 VATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEM 68 Query: 87 YQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANA 146 + L++ + +++ S GK ++ + S K Y Sbjct: 69 LK---------------GLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRF 113 Query: 147 KRFSRKTVLQLSLRILDILEYIHEHE--YVHGDIKASNLLLNYKNPDQVYLVDYGLAYRY 204 K K + +IL L+++H +H D+K N+ + V + D GLA Sbjct: 114 KVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGS-VKIGDLGLATLM 172 Query: 205 CPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDN 264 + + GT EF + + + D+ G CM++ T P+ + Sbjct: 173 ---------RTSFAKSVIGTPEFMAPEMYEEHY-DESVDVYAFGMCMLEMATSEYPYSEC 222 Query: 265 LKDPKYVRD 273 + R Sbjct: 223 QNAAQIYRK 231 >4K33-A nrPDB Length = 325 Score = 120 bits (301), Expect = 1e-27, Method: Composition-based stats. Identities = 46/309 (14%), Positives = 112/309 (36%), Gaps = 26/309 (8%) Query: 17 RHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMN--SSESVGSDAPCVVKVEP 74 +++E + ++++ +G P+G+G FG + +A+ + VK+ Sbjct: 18 ANVSELELPADPKWELSRARLTLGKPLGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKMLK 77 Query: 75 SDN--GPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMD 132 D L + + + + I G P + + G F+ Sbjct: 78 DDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGP-LYVLVEYAAKGNLREFL-RA 135 Query: 133 RFGSDLQKIYEANAKR---FSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKN 189 R L ++ + + K ++ + ++ +EY+ + +H D+ A N+L+ N Sbjct: 136 RRPPGLDYSFDTSKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDN 195 Query: 190 PDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGY 249 + + D+GLA +KE +++ + +A + + D+ G Sbjct: 196 --VMKIADFGLARDVHNLDYYKETTNGRL-----PVKWMAPEALFDRVYTHQSDVWSFGV 248 Query: 250 CMIQWLT-GHLPWEDNLKDPKYVRDSKIRY-------RENIASLMDKCFPEKNKPGEIAK 301 + + T G P+ + + + ++ +M +C+ P + Sbjct: 249 LLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAA--PSQRPT 306 Query: 302 YMETVKLLD 310 + + V+ LD Sbjct: 307 FKQLVEDLD 315 >4OLI-A nrPDB Length = 645 Score = 120 bits (300), Expect = 1e-27, Method: Composition-based stats. Identities = 62/314 (19%), Positives = 116/314 (36%), Gaps = 40/314 (12%) Query: 30 TDMAKKEW-KVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQ 88 + K + K +G+G FG + L + G+ VK +D GP Sbjct: 347 PTVFHKRYLKKIRDLGEGHFGKVSL-YCYDPTNDGTGEMVAVKALKADCGPQH------- 398 Query: 89 RAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYEANAK 147 + Q+ R L + + KY G + G+ ++M+ L+ ++ Sbjct: 399 ---RSGWKQEIDILRTLYHEHIIKYKGC--CEDQGEKSLQLVMEYVPLGSLRDYLPRHS- 452 Query: 148 RFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPE 207 +L + +I + + Y+H Y+H ++ A N+LL+ V + D+GLA PE Sbjct: 453 -IGLAQLLLFAQQICEGMAYLHSQHYIHRNLAARNVLLDNDR--LVKIGDFGLAKA-VPE 508 Query: 208 GVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT----GHLPWED 263 G H+ Y+ + + + + D+ G + + LT P Sbjct: 509 G-HEYYRVREDGDS--PVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTK 565 Query: 264 NLK-------DPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPL 316 L+ +R +++ R DKC P E+ M+ + + +P Sbjct: 566 FLELIGIAQGQMTVLRLTELLERGERLPRPDKC------PCEVYHLMKNCWETEASFRPT 619 Query: 317 YENLRDILLQGLKA 330 +ENL IL + Sbjct: 620 FENLIPILKTVHEK 633 Score = 59.5 bits (142), Expect = 2e-09, Method: Composition-based stats. Identities = 37/286 (12%), Positives = 77/286 (26%), Gaps = 31/286 (10%) Query: 43 IGQGGFGCIYLADMNSSESVGSDAPCVVKVEP----SDNGPLFTELKFYQRAAKPEQIQK 98 +GQG +Y + S + + +P D G + + + Sbjct: 53 LGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALA 112 Query: 99 WIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSD-LQKIYEANAKRFSRKTVLQL 157 + T L + M+ + L + + Sbjct: 113 FYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVV 172 Query: 158 SLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQ-----VYLVDYGLAYRYCPEGVHKE 212 + ++ L Y+ VHG++ N+LL + + L D G+ E Sbjct: 173 AQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVE 232 Query: 213 YKEDPKRCHDGTIEFTSIDAHNGVAPSRRG--DLEILGYCMIQWLT-GHLPWEDNLKDPK 269 I + + + G A S D G +++ G P + K Sbjct: 233 R-----------IPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEK 281 Query: 270 YVRDSKIRYRENIAS-----LMDKCFPEKNKPGEIAKYMETVKLLD 310 + + L +C + P + + ++ L Sbjct: 282 EHFYQRQHRLPEPSCPQLATLTSQCLTYE--PTQRPSFRTILRDLT 325 >3PG1-A nrPDB Length = 362 Score = 120 bits (300), Expect = 1e-27, Method: Composition-based stats. Identities = 31/260 (11%), Positives = 80/260 (30%), Gaps = 18/260 (6%) Query: 37 WKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQI 96 + V I G +G + + V V + ++ +R + Sbjct: 24 YTVQRFISSGSYGAVCAGVDSEGIPVAIKRVFN-TVSDGRTVNILSDSFLCKRV-----L 77 Query: 97 QKWIRTRKLKYLGVPKYWGSGLH-DKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVL 155 ++ + + +H ++ +++ + +DL ++ S + + Sbjct: 78 REIRLLNHFHHPNILGLRDIFVHFEEPAMHKLYLVTELMRTDLAQVIHDQRIVISPQHIQ 137 Query: 156 QLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKE 215 IL L +HE VH D+ N+LL + + + + D+ LA + Y Sbjct: 138 YFMYHILLGLHVLHEAGVVHRDLHPGNILL--ADNNDITICDFNLAREDTADANKTHYVT 195 Query: 216 DPKRCHDGTIEFTSIDAHN-GVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDS 274 + + + ++ D+ G M + + + + + Sbjct: 196 HRW--------YRAPELVMQFKGFTKLVDMWSAGCVMAEMFNRKALFRGSTFYNQLNKIV 247 Query: 275 KIRYRENIASLMDKCFPEKN 294 ++ I ++ P Sbjct: 248 EVVGTPKIEDVVMFSSPSAR 267 >3GQL-A nrPDB Length = 326 Score = 120 bits (300), Expect = 1e-27, Method: Composition-based stats. Identities = 47/294 (15%), Positives = 104/294 (35%), Gaps = 32/294 (10%) Query: 35 KEWKVGLPIGQGGFGCIYLADMN--SSESVGSDAPCVVKVEPSDN-----GPLFTELKFY 87 +G P+G+G FG + LA+ + VK+ SD L +E++ Sbjct: 28 DRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMM 87 Query: 88 QRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAK 147 + K + I + + + G ++ R L+ Y + Sbjct: 88 KMIGKHKNIINLLGACTQDGP----LYVIVEYASKGNLREYL-QARRPPGLEYCYNPSHN 142 Query: 148 R---FSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRY 204 S K ++ + ++ +EY+ + +H D+ A N+L+ N + + D+GLA Sbjct: 143 PEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDN--VMKIADFGLARDI 200 Query: 205 CPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT-GHLPWED 263 +K+ +++ + +A + + D+ G + + T G P+ Sbjct: 201 HHIDYYKKTTNGRL-----PVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPG 255 Query: 264 NLKDPKYVRDSKIRYRENI-------ASLMDKCFPEKNKPGEIAKYMETVKLLD 310 + + + + +M C+ P + + + V+ LD Sbjct: 256 VPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAV--PSQRPTFKQLVEDLD 307 >5U6C-A nrPDB Length = 315 Score = 120 bits (300), Expect = 1e-27, Method: Composition-based stats. Identities = 49/311 (15%), Positives = 116/311 (37%), Gaps = 32/311 (10%) Query: 28 IITDMAKKE--WKVGLPIGQGGFGCIYLADMNSSESVGSDAPCV-VKVEPS---DNGPLF 81 + D+ +G +G+G FG + ++ + +K++ S + Sbjct: 27 KLEDVVIDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFL 86 Query: 82 TELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKI 141 +E + + P ++ ++ G+PK K G + ++ L Sbjct: 87 SEAACMKDFSHPNVMRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYL--------LYSR 138 Query: 142 YEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 E K +T+L+ + I +EY+ ++H D+ A N +L ++ V + D+GL+ Sbjct: 139 LETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCML--RDDMTVCVADFGLS 196 Query: 202 YRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT-GHLP 260 + +++ + +++ +I++ + + D+ G M + T G P Sbjct: 197 KKIYSGDYYRQGRIAKM-----PVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTP 251 Query: 261 WEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENL 320 + Y + +D E+ + M + D ++P + L Sbjct: 252 YPGVQNHEMYDYLLHGHRLKQPEDCLD----------ELYEIMYSCWRTDPLDRPTFSVL 301 Query: 321 RDILLQGLKAI 331 R L + L+++ Sbjct: 302 RLQLEKLLESL 312 >3QGY-A nrPDB Length = 286 Score = 120 bits (300), Expect = 1e-27, Method: Composition-based stats. Identities = 43/280 (15%), Positives = 98/280 (35%), Gaps = 43/280 (15%) Query: 41 LPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWI 100 IG G FG ++L + + V +K E + + + P+ +Q Sbjct: 33 QEIGSGQFGLVHLGYWLNKDKVAIK---TIKEGSMSEDDFIEEAEVMMKLSHPKLVQ--- 86 Query: 101 RTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSD-LQKIYEANAKRFSRKTVLQLSL 159 +G L ++ + L F+ +T+L + L Sbjct: 87 ------------LYGVCLEQAP----ICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCL 130 Query: 160 RILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKR 219 + + + Y+ E +H D+ A N L+ + + D+G+ + Sbjct: 131 DVCEGMAYLEEACVIHRDLAARNCLVGEN--QVIKVSDFGMTRFVLDDQ------YTSST 182 Query: 220 CHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQ-WLTGHLPWEDNLKDPKYVRDSKIRY 278 +++ S + + S + D+ G M + + G +P+E+ + + V D + Sbjct: 183 GTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYEN-RSNSEVVEDISTGF 241 Query: 279 R--------ENIASLMDKCFPEKNKPGEIAKYMETVKLLD 310 R ++ +M+ C+ K +P + + ++ L Sbjct: 242 RLYKPRLASTHVYQIMNHCW--KERPEDRPAFSRLLRQLA 279 >3ALO-A nrPDB Length = 327 Score = 119 bits (299), Expect = 2e-27, Method: Composition-based stats. Identities = 45/314 (14%), Positives = 103/314 (32%), Gaps = 49/314 (15%) Query: 31 DMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRA 90 D ++ K IG+G +G + S + + V+ + L +L R+ Sbjct: 18 DFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRS 77 Query: 91 AKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYE----ANA 146 + + +++G+ + + ++ M+ + K Y+ Sbjct: 78 SD--------------CPYIVQFYGALFREGDC----WICMELMSTSFDKFYKYVYSVLD 119 Query: 147 KRFSRKTVLQLSLRILDILEYIHEH-EYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYC 205 + + +++L + L ++ E+ + +H DIK SN+LL+ + L D+G++ + Sbjct: 120 DVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSG--NIKLCDFGISGQLV 177 Query: 206 PEGVHKEYKEDPKRCHDGTIEFTSIDAHNG----VAPSRRGDLEILGYCMIQWLTGHLP- 260 G + + + + R D+ LG + + TG P Sbjct: 178 DSIAKTR--------DAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPY 229 Query: 261 --WEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLY- 317 W V E+ ++ D +++P Y Sbjct: 230 PKWNSVFDQLTQVVKGD--------PPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYK 281 Query: 318 ENLRDILLQGLKAI 331 E L+ + + Sbjct: 282 ELLKHPFILMYEER 295 >1ZXE-A nrPDB Length = 303 Score = 119 bits (298), Expect = 2e-27, Method: Composition-based stats. Identities = 41/251 (16%), Positives = 84/251 (33%), Gaps = 40/251 (15%) Query: 43 IGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRT 102 +GQG FG + A + +K L + + + Sbjct: 14 LGQGAFGQVVKA-----RNALDSRYYAIKKIRHTEEKL------------STILSEVMLL 56 Query: 103 RKLKYLGVPKYWGSGLHDK---------NGKSYRFMIMDRF-GSDLQKIYEANAKRFSRK 152 L + V +Y+ + L + KS F+ M+ L + + R Sbjct: 57 ASLNHQYVVRYYAAWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQRD 116 Query: 153 TVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAY-------RYC 205 +L +IL+ L YIH +H ++K N+ ++ V + D+GLA Sbjct: 117 EYWRLFRQILEALSYIHSQGIIHRNLKPMNIFIDESR--NVKIGDFGLAKNVHRSLDILK 174 Query: 206 PEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPS-RRGDLEILGYCMIQWLTGHLPWEDN 264 + + D GT + + + +G + D+ LG + + P+ Sbjct: 175 LDSQNLPGSSDNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMIY---PFSTG 231 Query: 265 LKDPKYVRDSK 275 ++ ++ + Sbjct: 232 MERVNILKKLR 242 >4BBM-A nrPDB Length = 331 Score = 119 bits (298), Expect = 2e-27, Method: Composition-based stats. Identities = 32/245 (13%), Positives = 87/245 (35%), Gaps = 30/245 (12%) Query: 33 AKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAK 92 + ++++ +G+G +G + + + + K SD+ + ++ Sbjct: 23 SMEKYENLGLVGEGSYGMVMKCRNKDTGRI----VAIKKFLESDDDKMVKKIA------- 71 Query: 93 PEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRK 152 +++ ++L++ + L K +++ + + E + Sbjct: 72 ---MREIKLLKQLRHENLVNL----LEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQ 124 Query: 153 TVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKE 212 V + +I++ + + H H +H DIK N+L++ V L D+G A Sbjct: 125 VVQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQSG--VVKLCDFGFARTLA------- 175 Query: 213 YKEDPKRCHDGTIEFTSIDAHNG-VAPSRRGDLEILGYCMIQWLTGHL--PWEDNLKDPK 269 + T + + + G V + D+ +G + + G P + ++ Sbjct: 176 APGEVYDDEVATRWYRAPELLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLY 235 Query: 270 YVRDS 274 ++ Sbjct: 236 HIMMC 240 >5O2C-A nrPDB Length = 380 Score = 119 bits (297), Expect = 2e-27, Method: Composition-based stats. Identities = 43/249 (17%), Positives = 86/249 (34%), Gaps = 29/249 (11%) Query: 28 IITDMAKKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKF 86 + T + + K + +G+G F +Y D + V K+ ++ E + Sbjct: 18 VATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEM 77 Query: 87 YQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANA 146 + L++ + +++ S GK ++ + S K Y Sbjct: 78 LK---------------GLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRF 122 Query: 147 KRFSRKTVLQLSLRILDILEYIHEHE--YVHGDIKASNLLLNYKNPDQVYLVDYGLAYRY 204 K K + +IL L+++H +H D+K N+ + V + D GLA Sbjct: 123 KVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGS-VKIGDLGLATLM 181 Query: 205 CPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDN 264 + + GT EF + + + D+ G CM++ T P+ + Sbjct: 182 ---------RTSFAKSVIGTPEFMAPEMYEEHY-DESVDVYAFGMCMLEMATSEYPYSEC 231 Query: 265 LKDPKYVRD 273 + R Sbjct: 232 QNAAQIYRK 240 >2F9G-A nrPDB Length = 353 Score = 119 bits (297), Expect = 2e-27, Method: Composition-based stats. Identities = 35/234 (14%), Positives = 78/234 (33%), Gaps = 26/234 (11%) Query: 27 EIITDMAKKEWKVGLPIGQGGFGCIYLADMN-SSESVGSDAPCVVKVEPSDNGPLFTELK 85 + I ++++ +G+G +G + A + E V K+EP D Sbjct: 3 KRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIK-----KIEPFDKPLFAL--- 54 Query: 86 FYQRAAKPEQIQKWIRTRKLKYLGVPKYWG-SGLHDKNGKSYRFMIMDRFGSDLQKIYEA 144 +++ + K+ + + + ++I + +DL ++ Sbjct: 55 --------RTLREIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVIST 106 Query: 145 NAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRY 204 S + + L ++ +H +H D+K SNLL+N + + D+GLA Sbjct: 107 QM--LSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSN--CDLKVCDFGLARII 162 Query: 205 CPEGVHKEYKEDPKRCHD---GTIEFTSIDA-HNGVAPSRRGDLEILGYCMIQW 254 + T + + + SR D+ G + + Sbjct: 163 DESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAEL 216 >6DBM-A nrPDB Length = 318 Score = 119 bits (297), Expect = 3e-27, Method: Composition-based stats. Identities = 45/233 (19%), Positives = 85/233 (36%), Gaps = 23/233 (9%) Query: 26 GEIITDMAKKEW-KVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTEL 84 G + K + K +G+G FG + L + G+ VK +D GP Sbjct: 21 GPGDPTVFHKRYLKKIRDLGEGHFGKVSL-YCYDPTNDGTGEMVAVKALKADAGPQH--- 76 Query: 85 KFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYE 143 + Q+ R L + + KY G + G + ++M+ L+ Sbjct: 77 -------RSGWKQEIDILRTLYHEHIIKYKGC--CEDAGAASLQLVMEYVPLGSLRDYLP 127 Query: 144 ANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYR 203 ++ +L + +I + + Y+H Y+H D+ A N+LL+ V + D+GLA Sbjct: 128 RHS--IGLAQLLLFAQQICEGMAYLHSQHYIHRDLAARNVLLDNDR--LVKIGDFGLAKA 183 Query: 204 YCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT 256 + +ED + + + D+ G + + LT Sbjct: 184 VPEGHEYYRVREDGDSPVF----WYAPECLKEYKFYYASDVWSFGVTLYELLT 232 >5WNO-A nrPDB Length = 330 Score = 119 bits (297), Expect = 3e-27, Method: Composition-based stats. Identities = 45/278 (16%), Positives = 103/278 (37%), Gaps = 32/278 (11%) Query: 38 KVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQ 97 K+ +G G FG ++ + P +KV +D ++ E ++ Sbjct: 25 KLDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTD------------QSQTDEMLE 72 Query: 98 KWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQL 157 + +L++ + K G +HD K + + R +LQ + + + + + Sbjct: 73 EATNMFRLRHDNLLKIIGFCMHDDGLK---IVTIYRPLGNLQNFLKLHKENLGAREQVLY 129 Query: 158 SLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDP 217 +I ++Y+ + VH D+ N+L+ K + V + D+GL+ + K Sbjct: 130 CYQIASGMQYLEKQRVVHRDLATRNVLV--KKFNHVEITDFGLSKILKHDADSITIKSGK 187 Query: 218 KRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT-GHLPWEDNLKDPKYVRDSKI 276 I++ +I+ + + D+ G + +T G P++ D + Sbjct: 188 VA-----IKWLAIEIFSKHCYTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDG 242 Query: 277 RY-------RENIASLMDKCFPE--KNKPGEIAKYMET 305 +++ + +C+ K++PG Y Sbjct: 243 NRLSQPPNCSQDLYQELLRCWMADPKSRPGFEILYERF 280 >4YHJ-A nrPDB Length = 584 Score = 119 bits (297), Expect = 3e-27, Method: Composition-based stats. Identities = 38/250 (15%), Positives = 80/250 (32%), Gaps = 31/250 (12%) Query: 32 MAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAA 91 + K ++ +G+GGFG + K+ K A Sbjct: 182 VTKNTFRHYRVLGKGGFGEV----------CACQVRATGKMYACKKLQKKRIKKRKGEAM 231 Query: 92 KPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSR 151 + + + + + + + ++ + + G IY F Sbjct: 232 ALNEKRILEKVQSRFVVSL-----AYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDE 286 Query: 152 KTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHK 211 + + + + LE + V+ D+K N+LL+ + + + D GLA Sbjct: 287 QRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRG--HIRISDLGLATEIP------ 338 Query: 212 EYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYV 271 + R GT+ + + + N + D LG + + + GH P++ KY Sbjct: 339 --EGQRVRGRVGTVGYMAPEVVNNEKYTFSPDWWGLGCLIYEMIQGHSPFK------KYK 390 Query: 272 RDSKIRYREN 281 K + Sbjct: 391 EKVKWEEVDQ 400 >5A46-A nrPDB Length = 386 Score = 119 bits (297), Expect = 3e-27, Method: Composition-based stats. Identities = 47/294 (15%), Positives = 104/294 (35%), Gaps = 32/294 (10%) Query: 35 KEWKVGLPIGQGGFGCIYLADMN--SSESVGSDAPCVVKVEPSDN-----GPLFTELKFY 87 +G P+G+G FG + LA+ + VK+ SD L +E++ Sbjct: 40 DRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMM 99 Query: 88 QRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAK 147 + K + I + + + G ++ R L+ Y + Sbjct: 100 KMIGKHKNIINLLGACTQDGP----LYVIVEYASKGNLREYL-QARRPPGLEYCYNPSHN 154 Query: 148 R---FSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRY 204 S K ++ + ++ +EY+ + +H D+ A N+L+ N + + D+GLA Sbjct: 155 PEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDN--VMKIADFGLARDI 212 Query: 205 CPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT-GHLPWED 263 +K+ +++ + +A + + D+ G + + T G P+ Sbjct: 213 HHIDYYKKTTNGRL-----PVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPG 267 Query: 264 NLKDPKYVRDSKIRYRENI-------ASLMDKCFPEKNKPGEIAKYMETVKLLD 310 + + + + +M C+ P + + + V+ LD Sbjct: 268 VPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAV--PSQRPTFKQLVEDLD 319 >5UIU-A nrPDB Length = 323 Score = 118 bits (296), Expect = 3e-27, Method: Composition-based stats. Identities = 39/221 (17%), Positives = 84/221 (38%), Gaps = 25/221 (11%) Query: 40 GLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKW 99 G +G+GGFG +Y +N++ +V + + F Q+ Sbjct: 52 GNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFD--------------QEI 97 Query: 100 IRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANA-KRFSRKTVLQLS 158 K ++ + + G + GS L ++ + S +++ Sbjct: 98 KVMAKCQHENLVELLG--FSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIA 155 Query: 159 LRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPK 218 + + ++HE+ ++H DIK++N+LL+ + D+GLA K + Sbjct: 156 QGAANGINFLHENHHIHRDIKSANILLDE--AFTAKISDFGLAR-----ASEKFAQTVMT 208 Query: 219 RCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHL 259 GT + + +A G + + D+ G +++ +TG Sbjct: 209 SRIVGTTAYMAPEALRG-EITPKSDIYSFGVVLLEIITGLP 248 >6GQK-A nrPDB Length = 328 Score = 118 bits (295), Expect = 4e-27, Method: Composition-based stats. Identities = 50/318 (15%), Positives = 111/318 (34%), Gaps = 33/318 (10%) Query: 11 RQSSAKRHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVV 70 + ++ + + + G +G G FG + A + V Sbjct: 17 SNGNNYSYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAQGLIKSDAAMTVAV 76 Query: 71 KV-----EPSDNGPLFTELKFYQRAAKPEQIQKWIR--TRKLKYLGVPKY--WGSGLHDK 121 K+ ++ L +ELK E I + T L + +Y +G L+ Sbjct: 77 KMLKPSAHSTEREALMSELKVLSYLGNHENIVNLLGACTHGGPTLVITEYCCYGDLLNFL 136 Query: 122 NGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKAS 181 K F+ DL K + + + +L S ++ + ++ +H D+ A Sbjct: 137 RRKRDEFVPYKVAPEDLYKDF------LTLEHLLSFSYQVAKGMAFLASKNCIHRDLAAR 190 Query: 182 NLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRR 241 N+LL + N + D+GLA + + + K +++ + ++ + Sbjct: 191 NILLTHGNIT--KICDFGLARDIKNDSNYVD-----KGNARLPVKWMAPESIFNSVYTFE 243 Query: 242 GDLEILGYCMIQWLT-GHLPWEDNLKDPKYVRDSKIRYR--------ENIASLMDKCFPE 292 D+ G + + + G P+ D K+ + K +R + +M C+ Sbjct: 244 SDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMSSPEYAPAEMYDIMKTCWDA 303 Query: 293 KNKPGEIAKYMETVKLLD 310 P + + + V+ ++ Sbjct: 304 D--PDKRPTFKQIVQDIE 319 >3EB0-A nrPDB Length = 383 Score = 118 bits (295), Expect = 5e-27, Method: Composition-based stats. Identities = 47/264 (17%), Positives = 91/264 (34%), Gaps = 27/264 (10%) Query: 31 DMAKKEWKVGLPIGQGGFGCI-YLADMNSSESVGSDAPCVV---KVEPSDNGPLFTELKF 86 + + K++ +G +G G FG + + D+ S + K D + + Sbjct: 3 ETSSKKYSLGKTLGTGSFGIVCEVFDIESGKRFALKKVLQDPRYKNRELDIMKVLDHVNI 62 Query: 87 YQRAA----------KPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGS 136 + KP Q K GV + S + + + Y +IM+ Sbjct: 63 IKLVDYFYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNVIMEYVPD 122 Query: 137 DLQKIYEA---NAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQV 193 L K+ ++ + + + ++ + +IH H DIK NLL+N K+ + + Sbjct: 123 TLHKVLKSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLLVNSKD-NTL 181 Query: 194 YLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRG-DLEILGYCMI 252 L D+G A + P Y + + + G DL +G Sbjct: 182 KLCDFGSAKKLIPSEPSVAYICSRF--------YRAPELMLGATEYTPSIDLWSIGCVFG 233 Query: 253 QWLTGHLPWEDNLKDPKYVRDSKI 276 + + G + + VR +I Sbjct: 234 ELILGKPLFSGETSIDQLVRIIQI 257 >2OGV-A nrPDB Length = 317 Score = 118 bits (295), Expect = 5e-27, Method: Composition-based stats. Identities = 49/289 (16%), Positives = 102/289 (35%), Gaps = 31/289 (10%) Query: 35 KEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPS-----DNGPLFTELKFYQR 89 + G +G G FG + A + VK+ S + L +ELK Sbjct: 38 NNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSH 97 Query: 90 AAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRF 149 + E I + LG + G L Y ++ + + + + Sbjct: 98 LGQHENI--------VNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEADLDKEDGRPL 149 Query: 150 SRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGV 209 + +L S ++ + ++ +H D+ A N+LL N + D+GLA + Sbjct: 150 ELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLT--NGHVAKIGDFGLARDIMNDSN 207 Query: 210 HKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT-GHLPWEDNLKDP 268 + K +++ + ++ + + D+ G + + + G P+ L + Sbjct: 208 YI-----VKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNS 262 Query: 269 KYVRDSKIRYR--------ENIASLMDKCFPEKNKPGEIAKYMETVKLL 309 K+ + K Y+ +NI S+M C+ + P + + L Sbjct: 263 KFYKLVKDGYQMAQPAFAPKNIYSIMQACWALE--PTHRPTFQQICSFL 309 >5O0Y-A nrPDB Length = 579 Score = 118 bits (294), Expect = 5e-27, Method: Composition-based stats. Identities = 42/268 (15%), Positives = 100/268 (37%), Gaps = 27/268 (10%) Query: 30 TDMAKKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQ 88 + + +G+GGF +Y A D+ V + K + + Sbjct: 279 HPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENY------- 331 Query: 89 RAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKR 148 +++ ++L + + K + D + +++ + Y K Sbjct: 332 ---HKHACREYRIHKELDHPRIVKLYDYFSLDTDSFC---TVLEYCEGNDLDFYLKQHKL 385 Query: 149 FSRKTVLQLSLRILDILEYIHEHE--YVHGDIKASNLLLNYKNPD-QVYLVDYGLAYRYC 205 S K + ++I++ L+Y++E + +H D+K N+LL ++ + D+GL+ Sbjct: 386 MSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMD 445 Query: 206 PEGVHKEYKEDPKRCHDGTIEFTSIDA-HNGVAP---SRRGDLEILGYCMIQWLTGHLPW 261 + + + GT + + G P S + D+ +G Q L G P+ Sbjct: 446 DDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPF 505 Query: 262 ------EDNLKDPKYVRDSKIRYRENIA 283 +D L++ ++ +++++ Sbjct: 506 GHNQSQQDILQENTILKATEVQFPPKPV 533 >3VHK-A nrPDB Length = 368 Score = 118 bits (294), Expect = 5e-27, Method: Composition-based stats. Identities = 57/360 (15%), Positives = 113/360 (31%), Gaps = 76/360 (21%) Query: 15 AKRHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEP 74 E+ + + K+G P+G+G FG + AD + + VK+ Sbjct: 9 PLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLK 68 Query: 75 -----SDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDK-------N 122 S++ L +ELK + G P Sbjct: 69 EGATHSEHRALMSELKILIHIG--HHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLR 126 Query: 123 GKSYRFMIM-----------DRFGS---------------------------DLQKIYEA 144 K F+ D G+ L + E Sbjct: 127 SKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEE 186 Query: 145 NAKR------FSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDY 198 A + + ++ S ++ +E++ + +H D+ A N+LL+ KN V + D+ Sbjct: 187 EAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKN--VVKICDF 244 Query: 199 GLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT-G 257 GLA ++K+ K +++ + + + + D+ G + + + G Sbjct: 245 GLAR-----DIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLG 299 Query: 258 HLPWEDNLKDPKYVRDSKIRYR--------ENIASLMDKCFPEKNKPGEIAKYMETVKLL 309 P+ D ++ R K R + M C+ +P + + E V+ L Sbjct: 300 ASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWH--GEPSQRPTFSELVEHL 357 >3IO7-A nrPDB Length = 313 Score = 118 bits (294), Expect = 6e-27, Method: Composition-based stats. Identities = 41/229 (17%), Positives = 91/229 (39%), Gaps = 21/229 (9%) Query: 29 ITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQ 88 +T ++ K +G+G FG + + + + + V K++ S L Sbjct: 22 MTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFE---- 77 Query: 89 RAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFG-SDLQKIYEANAK 147 ++ + L++ + KY G + G+ +IM+ L+ + + + Sbjct: 78 --------REIEILKSLQHDNIVKYKG--VCYSAGRRNLKLIMEYLPYGSLRDYLQKHKE 127 Query: 148 RFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPE 207 R +LQ + +I +EY+ Y+H D+ N+L+ N ++V + D+GL + Sbjct: 128 RIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVE--NENRVKIGDFGLTKVLPQD 185 Query: 208 GVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT 256 + + KE + I + + ++ S D+ G + + T Sbjct: 186 KEYYKVKEPGES----PIFWYAPESLTESKFSVASDVWSFGVVLYELFT 230 >4XCU-A nrPDB Length = 300 Score = 118 bits (294), Expect = 6e-27, Method: Composition-based stats. Identities = 46/296 (15%), Positives = 104/296 (35%), Gaps = 45/296 (15%) Query: 35 KEWKVGLPIGQGGFGCIYLA-----DMNSSESVGSDAPCVVKVEPSDN--GPLFTELKFY 87 +G P+G+G FG + A D + + A ++K SD L +E++ Sbjct: 17 DRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVM 76 Query: 88 QRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAK 147 + ++ + G + + G Y + G+ + + Sbjct: 77 KLIG--------------RHKNIINLLG--VCTQEGPLYVIVECAAKGNLREFLRARRPP 120 Query: 148 -----RFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAY 202 S ++ + ++ ++Y+ + +H D+ A N+L+ N + + D+GLA Sbjct: 121 GSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDN--VMKIADFGLAR 178 Query: 203 RYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT-GHLPW 261 GVH +++ + +A + + D+ G + + T G P+ Sbjct: 179 -----GVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPY 233 Query: 262 EDNLKDPKYVRDSKIRYRENI-------ASLMDKCFPEKNKPGEIAKYMETVKLLD 310 + + + + LM +C+ P + + + V+ LD Sbjct: 234 PGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAA--PSQRPTFKQLVEALD 287 >3V5Q-A nrPDB Length = 297 Score = 118 bits (294), Expect = 6e-27, Method: Composition-based stats. Identities = 41/292 (14%), Positives = 94/292 (32%), Gaps = 46/292 (15%) Query: 26 GEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELK 85 G + + +++ + +G+G FG ++LA+ + VK LK Sbjct: 6 GIHVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVK-----------ALK 54 Query: 86 FYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF----------- 134 AA+ + ++ L++ + K++G M+ + Sbjct: 55 DPTLAARKDFQREAELLTNLQHEHIVKFYGV----CGDGDPLIMVFEYMKHGDLNKFLRA 110 Query: 135 -GSDLQKIYEANAK----RFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKN 189 G D + + + +L ++ +I + Y+ +VH D+ N L+ Sbjct: 111 HGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANL 170 Query: 190 PDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGY 249 V + D+G++ V+ I + ++ + D+ G Sbjct: 171 --LVKIGDFGMSR-----DVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGV 223 Query: 250 CMIQ-WLTGHLPWEDNLKDPKYVRDSKIRYRENI-------ASLMDKCFPEK 293 + + + G PW ++ R E +M C+ + Sbjct: 224 ILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQRE 275 >3N9X-A nrPDB Length = 432 Score = 118 bits (294), Expect = 7e-27, Method: Composition-based stats. Identities = 47/246 (19%), Positives = 89/246 (36%), Gaps = 34/246 (13%) Query: 28 IITDMAKKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKF 86 I + + IG+G +G +YLA D N+ ++V + + D + E+ Sbjct: 19 IKNVHVPDNYIIKHLIGRGSYGYVYLAYDKNTEKNVAIKKVNRMFEDLIDCKRILREITI 78 Query: 87 YQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANA 146 R I+ L L +P D +++++ SDL+K+++ Sbjct: 79 LNRLKSDYIIR-------LYDLIIPD-------DLLKFDELYIVLEIADSDLKKLFKT-P 123 Query: 147 KRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCP 206 + + + + +L +IHE +H D+K +N LLN V + D+GLA Sbjct: 124 IFLTEEHIKTILYNLLLGENFIHESGIIHRDLKPANCLLNQD--CSVKVCDFGLARTINS 181 Query: 207 E---------------GVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRG-DLEILGYC 250 E G H + + H T + + + + D+ G Sbjct: 182 EKDTNIVNDLEENEEPGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTKSIDIWSTGCI 241 Query: 251 MIQWLT 256 + L Sbjct: 242 FAELLN 247 >5HLW-A nrPDB Length = 299 Score = 117 bits (293), Expect = 7e-27, Method: Composition-based stats. Identities = 47/279 (16%), Positives = 103/279 (36%), Gaps = 31/279 (11%) Query: 41 LPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWI 100 IG+G FGC+Y + ++ G C VK + + + + + I Sbjct: 26 EVIGRGHFGCVYHGTLLDND--GKKIHCAVK----------SLNRITDIGEVSQFLTEGI 73 Query: 101 RTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFG-SDLQKIYEANAKRFSRKTVLQLSL 159 + + V G L + +++ DL+ + K ++ L Sbjct: 74 IMKDFSHPNVLSLLGICL---RSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGL 130 Query: 160 RILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKR 219 ++ ++Y+ ++VH D+ A N +L+ K V + D+GLA + Y K Sbjct: 131 QVAKGMKYLASKKFVHRDLAARNCMLDEKFT--VKVADFGLARDMHD---KEYYSVHNKT 185 Query: 220 CHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT-GHLPWED--NLKDPKYVRDSKI 276 +++ ++++ + + D+ G + + +T G P+ D Y+ + Sbjct: 186 GAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRR 245 Query: 277 RYR-----ENIASLMDKCFPEKNKPGEIAKYMETVKLLD 310 + + + +M KC+ K + E V + Sbjct: 246 LLQPEYCPDPLYEVMLKCWHPKA--EMRPSFSELVSRIS 282 >4GS6-A nrPDB Length = 315 Score = 117 bits (293), Expect = 7e-27, Method: Composition-based stats. Identities = 50/307 (16%), Positives = 107/307 (34%), Gaps = 51/307 (16%) Query: 29 ITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQ 88 + + KE +V +G+G FG + A + + + ++E F Sbjct: 3 LHMIDYKEIEVEEVVGRGAFGVVCKAKWRAKDV------AIKQIESESERKAF------- 49 Query: 89 RAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYEANAK 147 I + + ++ + + K +G+ L+ ++M+ G L + Sbjct: 50 -------IVELRQLSRVNHPNIVKLYGACLNPVC------LVMEYAEGGSLYNVLHGAEP 96 Query: 148 --RFSRKTVLQLSLRILDILEYIHE---HEYVHGDIKASNLLLNYKNPDQVYLVDYGLAY 202 ++ + L+ + Y+H +H D+K NLLL + + D+G A Sbjct: 97 LPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGT-VLKICDFGTA- 154 Query: 203 RYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWE 262 C H + G+ + + + G S + D+ G + + +T P+ Sbjct: 155 --CDIQTHMT-------NNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPF- 204 Query: 263 DNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRD 322 D + P + + + KN P I M D +++P E + Sbjct: 205 DEIGGPAFRIMWAVHNGTRPPLI-------KNLPKPIESLMTRCWSKDPSQRPSMEEIVK 257 Query: 323 ILLQGLK 329 I+ ++ Sbjct: 258 IMTHLMR 264 >2W1I-A nrPDB Length = 326 Score = 117 bits (293), Expect = 8e-27, Method: Composition-based stats. Identities = 40/223 (17%), Positives = 88/223 (39%), Gaps = 21/223 (9%) Query: 35 KEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPE 94 + K +G+G FG + + + + + V K++ S L Sbjct: 41 RHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFE---------- 90 Query: 95 QIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFG-SDLQKIYEANAKRFSRKT 153 ++ + L++ + KY G + G+ +IM+ L+ + + +R Sbjct: 91 --REIEILKSLQHDNIVKYKG--VCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIK 146 Query: 154 VLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEY 213 +LQ + +I +EY+ Y+H D+ N+L+ N ++V + D+GL + + + Sbjct: 147 LLQYTSQICKGMEYLGTKRYIHRDLATRNILVE--NENRVKIGDFGLTKVLPQDKEYYKV 204 Query: 214 KEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT 256 KE + I + + ++ S D+ G + + T Sbjct: 205 KEPGES----PIFWYAPESLTESKFSVASDVWSFGVVLYELFT 243 >3NIE-A nrPDB Length = 429 Score = 117 bits (292), Expect = 9e-27, Method: Composition-based stats. Identities = 47/249 (18%), Positives = 92/249 (36%), Gaps = 37/249 (14%) Query: 28 IITDMAKKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKF 86 I +++ IG+G +G +YLA D N++++V + + D + E+ Sbjct: 21 IKNVKVPDNYEIKHLIGRGSYGYVYLAYDKNANKNVAIKKVNRMFEDLIDCKRILREITI 80 Query: 87 YQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANA 146 R I+ L L +P+ D +++++ SDL+K+++ Sbjct: 81 LNRLKSDYIIR-------LHDLIIPE-------DLLKFDELYIVLEIADSDLKKLFKT-P 125 Query: 147 KRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCP 206 + + V + +L ++IHE +H D+K +N LLN V + D+GLA Sbjct: 126 IFLTEQHVKTILYNLLLGEKFIHESGIIHRDLKPANCLLNQD--CSVKICDFGLARTINS 183 Query: 207 E------------------GVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRG-DLEIL 247 + G H + + H T + + + D+ Sbjct: 184 DKDIHIVNDLEEKEENEEPGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWST 243 Query: 248 GYCMIQWLT 256 G + L Sbjct: 244 GCIFAELLN 252 >3DKO-A nrPDB Length = 318 Score = 117 bits (292), Expect = 1e-26, Method: Composition-based stats. Identities = 49/314 (15%), Positives = 104/314 (33%), Gaps = 41/314 (13%) Query: 10 GRQSSAKRHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMN-SSESVGSDAPC 68 + + AV + ++ K+ IG G FG + + + + A Sbjct: 18 KTYIDPETYEDPNRAVHQFAKELDASCIKIERVIGAGEFGEVCSGRLKLPGKRDVAVAIK 77 Query: 69 VVKVEPSDNGP--LFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSY 126 +KV ++ E + P + +L G Sbjct: 78 TLKVGYTEKQRRDFLCEASIMGQFDHPNVV----------HLEGVVTRG---------KP 118 Query: 127 RFMIMDRF-GSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLL 185 ++++ L + +F+ ++ + I + Y+ + YVH D+ A N+L+ Sbjct: 119 VMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGMRYLADMGYVHRDLAARNILV 178 Query: 186 NYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLE 245 N + D+GL+ + K + +T+ +A + D+ Sbjct: 179 NSNLVC--KVSDFGLSRVIEDDPEAVYTTTGGKI----PVRWTAPEAIQYRKFTSASDVW 232 Query: 246 ILGYCMIQ-WLTGHLPWEDNLKDPKYVRDSKIRYRENIA--------SLMDKCFPEKNKP 296 G M + G P+ D + + ++ + YR LM C+ ++ Sbjct: 233 SYGIVMWEVMSYGERPYWD-MSNQDVIKAIEEGYRLPAPMDCPAGLHQLMLDCWQKER-- 289 Query: 297 GEIAKYMETVKLLD 310 E K+ + V +LD Sbjct: 290 AERPKFEQIVGILD 303 >3QUP-A nrPDB Length = 323 Score = 117 bits (292), Expect = 1e-26, Method: Composition-based stats. Identities = 51/320 (15%), Positives = 106/320 (33%), Gaps = 33/320 (10%) Query: 17 RHLAEQFAVGEIITDMAKK--EWKVGLPIGQGGFGCIYLADMNSSE----SVGSDAPCVV 70 L + E + D+ ++ +G +G+G FG + A + + V Sbjct: 3 DSLGISDELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKAD 62 Query: 71 KVEPSDNGPLFTELKFYQRAAKPEQIQK-WIRTRKLKYLGVPKYWGSGLHDKNGKSYRFM 129 + SD E + P + + R +P K+G + F+ Sbjct: 63 IIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFL 122 Query: 130 IMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKN 189 + R G N +T+++ + I +EY+ ++H D+ A N +L Sbjct: 123 LASRIGE--------NPFNLPLQTLVRFMVDIACGMEYLSSRNFIHRDLAARNCMLAED- 173 Query: 190 PDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGY 249 V + D+GL+ + +++ +++ ++++ + D+ G Sbjct: 174 -MTVCVADFGLSRKIYSGDYYRQGCASKL-----PVKWLALESLADNLYTVHSDVWAFGV 227 Query: 250 CMIQWLT-GHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKL 308 M + +T G P+ Y + M E+ M Sbjct: 228 TMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECM----------EEVYDLMYQCWS 277 Query: 309 LDYTEKPLYENLRDILLQGL 328 D ++P + LR L L Sbjct: 278 ADPKQRPSFTCLRMELENIL 297 >4R7H-A nrPDB Length = 343 Score = 117 bits (292), Expect = 1e-26, Method: Composition-based stats. Identities = 52/294 (17%), Positives = 108/294 (36%), Gaps = 28/294 (9%) Query: 35 KEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPS-----DNGPLFTELKFYQR 89 + G +G G FG + A + VK+ S + L +ELK Sbjct: 50 NNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSH 109 Query: 90 AAKPEQIQKWIR--TRKLKYLGVPKYWGSG-LHDKNGKSYRFMIMDRF--GSDLQKIYEA 144 + E I + T L + +Y G L + + M+ G D + + + Sbjct: 110 LGQHENIVNLLGACTHGGPVLVITEYCTYGDLLNFLRRKAEAMLGPSLSPGQDPEGLDKE 169 Query: 145 NAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRY 204 + + + +L S ++ + ++ +H D+ A N+LL N + D+GLA Sbjct: 170 DGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLT--NGHVAKIGDFGLARDI 227 Query: 205 CPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT-GHLPWED 263 + + K +++ + ++ + + D+ G + + + G P+ Sbjct: 228 MNDSNYI-----VKGNARLPVKWMAPESIFDSVYTVQSDVWSYGILLWEIFSLGLNPYPG 282 Query: 264 NLKDPKYVRDSKIRYR--------ENIASLMDKCFPEKNKPGEIAKYMETVKLL 309 L + K+ + K Y+ +NI S+M C+ + P + + L Sbjct: 283 ILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALE--PTHRPTFQQITSFL 334 >3GC9-A nrPDB Length = 370 Score = 117 bits (292), Expect = 1e-26, Method: Composition-based stats. Identities = 45/238 (18%), Positives = 88/238 (36%), Gaps = 35/238 (14%) Query: 41 LPIGQGGFGCI---YLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQ 97 P+G G +G + Y A + VK L + Y+ +++ Sbjct: 34 RPVGSGAYGSVCSAYDARLRQK--------VAVKKLSRPFQSLIHARRTYR------ELR 79 Query: 98 KWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQL 157 + +G+ + S +++ G+DL I ++ A S + V L Sbjct: 80 LLKHLKHENVIGLLDVFTPATS-IEDFSEVYLVTTLMGADLNNIVKSQA--LSDEHVQFL 136 Query: 158 SLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDP 217 ++L L+YIH +H D+K SN+ +N ++ ++D+GLA + E Sbjct: 137 VYQLLRGLKYIHSAGIIHRDLKPSNVAVNED--SELRILDFGLARQADEEMT-------- 186 Query: 218 KRCHDGTIEFTSIDAHNGVAPSRR-GDLEILGYCMIQWLTGH--LPWEDNLKDPKYVR 272 + T + + + + D+ +G M + L G P D + K + Sbjct: 187 --GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIM 242 >4AT3-A nrPDB Length = 299 Score = 117 bits (292), Expect = 1e-26, Method: Composition-based stats. Identities = 40/292 (13%), Positives = 94/292 (32%), Gaps = 43/292 (14%) Query: 23 FAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFT 82 A+ + + + + +G+G FG ++LA+ + VK + Sbjct: 1 GAMDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARK 60 Query: 83 ELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFG-SDLQKI 141 + ++ L++ + K++G + M+ + DL K Sbjct: 61 DFH-----------REAELLTNLQHEHIVKFYGVCVEGDP----LIMVFEYMKHGDLNKF 105 Query: 142 YEANAK------------RFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKN 189 A+ ++ +L ++ +I + Y+ +VH D+ N L+ Sbjct: 106 LRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENL 165 Query: 190 PDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGY 249 V + D+G++ V+ I + ++ + D+ LG Sbjct: 166 --LVKIGDFGMSR-----DVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGV 218 Query: 250 CMIQ-WLTGHLPWEDNLKDPKYVRDSKIRYRENI-------ASLMDKCFPEK 293 + + + G PW + ++ R + LM C+ + Sbjct: 219 VLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQRE 270 >2ZMD-A nrPDB Length = 390 Score = 117 bits (292), Expect = 1e-26, Method: Composition-based stats. Identities = 37/243 (15%), Positives = 81/243 (33%), Gaps = 37/243 (15%) Query: 32 MAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAA 91 + + + + IG GG ++ + + + + E+ + + Sbjct: 53 VKGRIYSILKQIGSGGSSKVFQVLNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQ 112 Query: 92 KPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSR 151 + + + + + D Y +M+M+ DL + K Sbjct: 113 Q-------------HSDKIIRLYDYEITD----QYIYMVMECGNIDLNSWLKKK-KSIDP 154 Query: 152 KTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHK 211 +L+ + IH+H VH D+K +N L+ + L+D+G+A + P+ Sbjct: 155 WERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVD---GMLKLIDFGIANQMQPDTTSV 211 Query: 212 EYKEDPKRCHDGTIEFTSIDAHNGVAPSRR-----------GDLEILGYCMIQWLTGHLP 260 K G + + +A ++ SR D+ LG + G P Sbjct: 212 -----VKDSQVGAVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTP 266 Query: 261 WED 263 ++ Sbjct: 267 FQQ 269 >4EUU-A nrPDB Length = 319 Score = 116 bits (291), Expect = 1e-26, Method: Composition-based stats. Identities = 40/239 (16%), Positives = 76/239 (31%), Gaps = 34/239 (14%) Query: 37 WKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQI 96 W + +GQG ++ + + +KV F + F + Q+ Sbjct: 11 WLLSDILGQGATANVFRGRHKKTGDL-----FAIKV--------FNNISFLRPVDV--QM 55 Query: 97 QKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYE-ANAKRFSRKTVL 155 +++ +KL + + K + M GS + E +NA L Sbjct: 56 REFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFL 115 Query: 156 QLSLRILDILEYIHEHEYVHGDIKASNLL--LNYKNPDQVYLVDYGLAYRYCPEGVHKEY 213 + ++ + ++ E+ VH +IK N++ + L D+G A + Sbjct: 116 IVLRDVVGGMNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFV-- 173 Query: 214 KEDPKRCHDGTIEFTSIDAHNG--------VAPSRRGDLEILGYCMIQWLTGHLPWEDN 264 GT E+ D + DL +G TG LP+ Sbjct: 174 ------SLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPF 226 >4EUT-A nrPDB Length = 396 Score = 116 bits (291), Expect = 1e-26, Method: Composition-based stats. Identities = 40/239 (16%), Positives = 76/239 (31%), Gaps = 34/239 (14%) Query: 37 WKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQI 96 W + +GQG ++ + + +KV F + F + Q+ Sbjct: 11 WLLSDILGQGATANVFRGRHKKTGDL-----FAIKV--------FNNISFLRPVDV--QM 55 Query: 97 QKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYE-ANAKRFSRKTVL 155 +++ +KL + + K + M GS + E +NA L Sbjct: 56 REFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFL 115 Query: 156 QLSLRILDILEYIHEHEYVHGDIKASNLL--LNYKNPDQVYLVDYGLAYRYCPEGVHKEY 213 + ++ + ++ E+ VH +IK N++ + L D+G A + Sbjct: 116 IVLRDVVGGMNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFV-- 173 Query: 214 KEDPKRCHDGTIEFTSIDAHNG--------VAPSRRGDLEILGYCMIQWLTGHLPWEDN 264 GT E+ D + DL +G TG LP+ Sbjct: 174 ------SLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPF 226 >2PSQ-A nrPDB Length = 370 Score = 116 bits (291), Expect = 1e-26, Method: Composition-based stats. Identities = 48/293 (16%), Positives = 113/293 (38%), Gaps = 30/293 (10%) Query: 35 KEWKVGLPIGQGGFGCIYLA-----DMNSSESVGSDAPCVVKVEP--SDNGPLFTELKFY 87 + +G P+G+G FG + +A D + + + A ++K + D L +E++ Sbjct: 81 DKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMM 140 Query: 88 QRAAKPEQIQKWIR--TRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEAN 145 + K + I + T+ + +Y G + ++ R M+ I Sbjct: 141 KMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYS----YDINRVP 196 Query: 146 AKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYC 205 ++ + K ++ + ++ +EY+ + +H D+ A N+L+ N + + D+GLA Sbjct: 197 EEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENN--VMKIADFGLARDIN 254 Query: 206 PEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT-GHLPWEDN 264 +K+ +++ + +A + + D+ G M + T G P+ Sbjct: 255 NIDYYKKTTNGRL-----PVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGI 309 Query: 265 LKDPKYVRDSKIRYRENI-------ASLMDKCFPEKNKPGEIAKYMETVKLLD 310 + + + + +M C+ P + + + V+ LD Sbjct: 310 PVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAV--PSQRPTFKQLVEDLD 360 >5HVK-A nrPDB Length = 315 Score = 116 bits (291), Expect = 1e-26, Method: Composition-based stats. Identities = 50/295 (16%), Positives = 100/295 (33%), Gaps = 36/295 (12%) Query: 40 GLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKW 99 G +G+G FG + V ++ + E+K Sbjct: 19 GEVLGKGCFGQAIKVTHRETGEVMVMKEL-IRFDEETQRTFLKEVKVM------------ 65 Query: 100 IRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSL 159 R L++ V K+ G D K F+ G L+ I ++ ++ + + Sbjct: 66 ---RCLEHPNVLKFIGVLYKD---KRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAK 119 Query: 160 RILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVH-------KE 212 I + Y+H +H ++ + N L+ + V + D+GLA E K+ Sbjct: 120 DIASGMAYLHSMNIIHRNLNSHNCLV--RENKNVVVADFGLARLMVDEKTQPEGLRSLKK 177 Query: 213 YKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVR 272 + G + + + NG + + D+ G + + + G + DP Y+ Sbjct: 178 PDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEII-GRV-----NADPDYL- 230 Query: 273 DSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDILLQG 327 + + N+ +D+ P P + LD ++P + L L Sbjct: 231 PRTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCC-DLDPEKRPSFVKLEHWLETL 284 >5EG3-A nrPDB Length = 334 Score = 116 bits (291), Expect = 1e-26, Method: Composition-based stats. Identities = 49/293 (16%), Positives = 111/293 (37%), Gaps = 30/293 (10%) Query: 35 KEWKVGLPIGQGGFGCIYLA-----DMNSSESVGSDAPCVVKVEP--SDNGPLFTELKFY 87 + +G P+G+G FG + +A D + + + A ++K + D L +E++ Sbjct: 35 DKLTLGKPLGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMM 94 Query: 88 QRAAKPEQIQKWIR--TRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEAN 145 + K + I + T+ + Y G + ++ R M+ I Sbjct: 95 KMIGKHKNIINLLGACTQDGPLYVIVAYASKGNLREYLRARRPPGMELS----PDINRVP 150 Query: 146 AKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYC 205 ++ + K ++ + ++ +EY+ + +H D+ A N+L+ N + + D+GLA Sbjct: 151 EEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENN--VMKIADFGLARDIN 208 Query: 206 PEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT-GHLPWEDN 264 KE +++ + +A + + D+ G M + T G P+ Sbjct: 209 NIDFFKETTNGRL-----PVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGI 263 Query: 265 LKDPKYVRDSKIRYRENI-------ASLMDKCFPEKNKPGEIAKYMETVKLLD 310 + + + + +M C+ P + + + V+ LD Sbjct: 264 PVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAV--PSQRPTFKQLVEDLD 314 >4C59-A nrPDB Length = 340 Score = 116 bits (290), Expect = 2e-26, Method: Composition-based stats. Identities = 55/332 (16%), Positives = 111/332 (33%), Gaps = 54/332 (16%) Query: 1 MPRVKAAQAGRQSSAKRHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLA-DMNSS 59 MP +GR S + + +GE+ +V + +GGF +Y A D+ S Sbjct: 2 MPGSLGGASGRDQS--DFVGQTVELGEL-------RLRVRRVLAEGGFAFVYEAQDVGSG 52 Query: 60 ESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKY---WGS 116 + E + + E+ F ++ + + + ++ Sbjct: 53 REYALKRLLSNEEEKNRA--IIQEVCFMKKLS--------------GHPNIVQFCSAASI 96 Query: 117 GLHDKNGKSYRFMIM-DRFGSDLQKIYEANAKR--FSRKTVLQLSLRILDILEYIHEHE- 172 G + + F+++ + L + + R S TVL++ + ++++H + Sbjct: 97 GKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGPLSCDTVLKIFYQTCRAVQHMHRQKP 156 Query: 173 -YVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKR-----CHDGTIE 226 +H D+K NLLL+ N + L D+G A + + + T Sbjct: 157 PIIHRDLKVENLLLS--NQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEEITRNTTPM 214 Query: 227 FTSIDAHN---GVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRYRENIA 283 + + + + + D+ LG + P+ED K +R +Y Sbjct: 215 YRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGAK----LRIVNGKYSIPPH 270 Query: 284 SLMDKCFPE------KNKPGEIAKYMETVKLL 309 F + P E E V L Sbjct: 271 DTQYTVFHSLIRAMLQVNPEERLSIAEVVHQL 302 >4JLC-A nrPDB Length = 657 Score = 116 bits (290), Expect = 2e-26, Method: Composition-based stats. Identities = 42/239 (17%), Positives = 76/239 (31%), Gaps = 34/239 (14%) Query: 37 WKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQI 96 W + +GQG ++ + + VKV F + F + Q+ Sbjct: 10 WLLSDILGQGATANVFRGRHKKTGDLY-----AVKV--------FNNISFLRPVDV--QM 54 Query: 97 QKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYE-ANAKRFSRKTVL 155 +++ +KL + + K + M GS + E +NA L Sbjct: 55 REFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFL 114 Query: 156 QLSLRILDILEYIHEHEYVHGDIKASNLL--LNYKNPDQVYLVDYGLAYRYCPEGVHKEY 213 + ++ + ++ E+ VH DIK N++ + L D+G A + Sbjct: 115 IVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFV-- 172 Query: 214 KEDPKRCHDGTIEFTSIDAHNG--------VAPSRRGDLEILGYCMIQWLTGHLPWEDN 264 GT E+ D + DL +G TG LP+ Sbjct: 173 ------SLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSVGVTFYHAATGSLPFRPF 225 >4NEU-A nrPDB Length = 333 Score = 115 bits (288), Expect = 3e-26, Method: Composition-based stats. Identities = 49/304 (16%), Positives = 106/304 (34%), Gaps = 39/304 (12%) Query: 32 MAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAA 91 M ++ + GGFG + L + + N L E K R Sbjct: 21 MKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNR-- 78 Query: 92 KPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF--GSDLQKIYEANAKRF 149 L++ V K G + + ++M+ G+ + + + Sbjct: 79 -------------LRHSRVVKLLGVIIEE----GKYSLVMEYMEKGNLMHVLKAEMSTPL 121 Query: 150 SRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA------YR 203 S K ++ L I++ + Y+H +H D+K N+L++ N + + D GLA Sbjct: 122 SVK--GRIILEIIEGMCYLHGKGVIHKDLKPENILVD--NDFHIKIADLGLASFKMWSKL 177 Query: 204 YCPEGVHKEYKEDPKRCHDGTIEFTSIDAHN--GVAPSRRGDLEILGYCMIQWLTGHLPW 261 E + + + GT+ + + + N P+ + D+ + P+ Sbjct: 178 NNEEHNELREVDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPY 237 Query: 262 EDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLR 321 E+ + + + + K R ++ + + C P EI M+ + +P + + Sbjct: 238 ENAICEQQLIMCIKSGNRPDVDDITEYC------PREIISLMKLCWEANPEARPTFPGIE 291 Query: 322 DILL 325 + Sbjct: 292 EKFR 295 >3M42-A nrPDB Length = 299 Score = 115 bits (287), Expect = 3e-26, Method: Composition-based stats. Identities = 31/187 (16%), Positives = 63/187 (33%), Gaps = 34/187 (18%) Query: 83 ELKFYQRAAKPEQIQKWIRT--RKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF--GSDL 138 E + + ++ + R + + + + G+ ++M+ G Sbjct: 44 EKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELF 103 Query: 139 QKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQV-YLVD 197 +I + + F+ + ++ I + ++Y+H H D+K NLL K P+ + L D Sbjct: 104 SRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTD 163 Query: 198 YGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTG 257 +G A G + D+ LG M L G Sbjct: 164 FGFAKETT-----------------------------GEKYDKSCDMWSLGVIMYILLCG 194 Query: 258 HLPWEDN 264 + P+ N Sbjct: 195 YPPFYSN 201 >6E4F-A nrPDB Length = 290 Score = 115 bits (287), Expect = 3e-26, Method: Composition-based stats. Identities = 41/271 (15%), Positives = 86/271 (31%), Gaps = 41/271 (15%) Query: 41 LPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWI 100 +G G FG + V +K E K + + +Q Sbjct: 37 KELGTGQFGVVKYGKWRGQYDVAIKM---IKEGSMSEDEFIEEAKVMMNLSHEKLVQ--- 90 Query: 101 RTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYEANAKRFSRKTVLQLSL 159 +G + F+I + L RF + +L++ Sbjct: 91 ------------LYGVCTKQRP----IFIITEYMANGCLLNYLREMRHRFQTQQLLEMCK 134 Query: 160 RILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKR 219 + + +EY+ +++H D+ A N L+N + V + D+GL+ + Sbjct: 135 DVCEAMEYLESKQFLHRDLAARNCLVN--DQGVVKVSDFGLSRYVLDDE------YTSSV 186 Query: 220 CHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT-GHLPWEDNLKDPKYVRDSKIRY 278 + ++ + S + D+ G M + + G +P+E ++ Sbjct: 187 GSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLR 246 Query: 279 -------RENIASLMDKCFPEKNKPGEIAKY 302 E + ++M C+ EK E + Sbjct: 247 LYRPHLASEKVYTIMYSCWHEKA--DERPTF 275 >6O8B-A nrPDB Length = 665 Score = 115 bits (287), Expect = 4e-26, Method: Composition-based stats. Identities = 41/239 (17%), Positives = 77/239 (32%), Gaps = 34/239 (14%) Query: 37 WKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQI 96 W + +GQG ++ + + +KV F + F + Q+ Sbjct: 17 WLLSDILGQGATANVFRGRHKKTGDL-----FAIKV--------FNNISFLRPVDV--QM 61 Query: 97 QKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYE-ANAKRFSRKTVL 155 +++ +KL + + K + M GS + E +NA L Sbjct: 62 REFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFL 121 Query: 156 QLSLRILDILEYIHEHEYVHGDIKASNLL--LNYKNPDQVYLVDYGLAYRYCPEGVHKEY 213 + ++ + ++ E+ VH +IK N++ + L D+G A + E Sbjct: 122 IVLRDVVGGMNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVE- 180 Query: 214 KEDPKRCHDGTIEFTSIDAHNG--------VAPSRRGDLEILGYCMIQWLTGHLPWEDN 264 GT E+ D + DL +G TG LP+ Sbjct: 181 -------LYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPF 232 >3C1X-A nrPDB Length = 373 Score = 114 bits (286), Expect = 5e-26, Method: Composition-based stats. Identities = 44/279 (15%), Positives = 104/279 (37%), Gaps = 31/279 (11%) Query: 41 LPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWI 100 IG+G FGC+Y + ++ G C VK + + + + + I Sbjct: 95 EVIGRGHFGCVYHGTLLDND--GKKIHCAVK----------SLNRITDIGEVSQFLTEGI 142 Query: 101 RTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFG-SDLQKIYEANAKRFSRKTVLQLSL 159 + + V G L + +++ DL+ + K ++ L Sbjct: 143 IMKDFSHPNVLSLLGICL---RSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGL 199 Query: 160 RILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKR 219 ++ ++++ ++VH D+ A N +L+ K V + D+GLA + + + + Sbjct: 200 QVAKGMKFLASKKFVHRDLAARNCMLDEKFT--VKVADFGLARDMYDKEFDSVHNKTGAK 257 Query: 220 CHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT-GHLPWED--NLKDPKYVRDSKI 276 +++ ++++ + + D+ G + + +T G P+ D Y+ + Sbjct: 258 L---PVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRR 314 Query: 277 RYR-----ENIASLMDKCFPEKNKPGEIAKYMETVKLLD 310 + + + +M KC+ K + E V + Sbjct: 315 LLQPEYCPDPLYEVMLKCWHPKA--EMRPSFSELVSRIS 351 >3PLS-A nrPDB Length = 298 Score = 114 bits (286), Expect = 5e-26, Method: Composition-based stats. Identities = 46/293 (15%), Positives = 107/293 (36%), Gaps = 35/293 (11%) Query: 23 FAVGEIITDMAKKEWKVG----LPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNG 78 A+ + D+ +V IG+G FG +Y + + + C +K Sbjct: 5 SALLAEVKDVLIPHERVVTHSDRVIGKGHFGVVYHGEYI--DQAQNRIQCAIK------- 55 Query: 79 PLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFG-SD 137 + + + +++ + R L + V G L + +++ D Sbjct: 56 ---SLSRITEMQQVEAFLREGLLMRGLNHPNVLALIGIML---PPEGLPHVLLPYMCHGD 109 Query: 138 LQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVD 197 L + + + + K ++ L++ +EY+ E ++VH D+ A N +L+ V + D Sbjct: 110 LLQFIRSPQRNPTVKDLISFGLQVARGMEYLAEQKFVHRDLAARNCMLDESFT--VKVAD 167 Query: 198 YGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT- 256 +GLA + Y R +++T++++ + + D+ G + + LT Sbjct: 168 FGLARDILD---REYYSVQQHRHARLPVKWTALESLQTYRFTTKSDVWSFGVLLWELLTR 224 Query: 257 GHLPWE-------DNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKY 302 G P+ + +++ +M +C+ P + Sbjct: 225 GAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSLYQVMQQCWEAD--PAVRPTF 275 >5MJB-A nrPDB Length = 305 Score = 114 bits (286), Expect = 5e-26, Method: Composition-based stats. Identities = 51/287 (17%), Positives = 92/287 (32%), Gaps = 41/287 (14%) Query: 38 KVGLPIGQGGFGCIYLADMN---SSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPE 94 K+ IG G FG +Y + E + +E + Sbjct: 29 KIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHRN 88 Query: 95 QIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF--GSDLQKIYEANAKRFSRK 152 I+ L KS MI+ F L N +F+ Sbjct: 89 IIR--------------------LEGVVTKSRPVMIITEFMENCALDSFLRQNDGQFTVI 128 Query: 153 TVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKE 212 ++ + I ++Y+ E YVH D+ A N+L+N + D+GL+ + Sbjct: 129 QLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVC--KVSDFGLSRYLQDDTSDPT 186 Query: 213 YKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT-GHLPWEDNLKDPKYV 271 Y + +T+ +A + D+ G M + ++ G P+ D + + + Sbjct: 187 YT--SSLGGKIPVRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWD-MSNQDVI 243 Query: 272 RDSKIRYRENIA--------SLMDKCFPEKNKPGEIAKYMETVKLLD 310 + YR LM C+ + ++ E V LD Sbjct: 244 NAIEQDYRLPPPMDCPAALHQLMLDCWQKDRNS--RPRFAEIVNTLD 288 >2JD5-A nrPDB Length = 373 Score = 114 bits (286), Expect = 5e-26, Method: Composition-based stats. Identities = 49/247 (19%), Positives = 92/247 (37%), Gaps = 25/247 (10%) Query: 36 EWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPE 94 + + +G G F ++LA DM ++ V KV E+K QR + Sbjct: 20 RYILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVRGDKVYTEAAED---EIKLLQRVNDAD 76 Query: 95 QIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEA-NAKRFSRKT 153 ++ + K H + M+ + G +L + + + Sbjct: 77 NTKEDSMGAN----HILKLLDHFNHKGPNGVHVVMVFEVLGENLLALIKKYEHRGIPLIY 132 Query: 154 VLQLSLRILDILEYIHEH-EYVHGDIKASNLLL----NYKNPDQVYLVDYGLAYRYCPEG 208 V Q+S ++L L+Y+H +H DIK N+L+ + +N Q+ + D G A Y Sbjct: 133 VKQISKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNACWYD--- 189 Query: 209 VHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDP 268 + Y + T E+ S + G D+ + + +TG +E + + Sbjct: 190 --EHYTNSIQ-----TREYRSPEVLLGAPWGCGADIWSTACLIFELITGDFLFEPD-EGH 241 Query: 269 KYVRDSK 275 Y +D Sbjct: 242 SYTKDDD 248 >4X7Q-B nrPDB Length = 312 Score = 114 bits (285), Expect = 6e-26, Method: Composition-based stats. Identities = 42/272 (15%), Positives = 88/272 (32%), Gaps = 24/272 (8%) Query: 36 EWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQ 95 E+++G +G+GGFG ++ + +KV P + + P + Sbjct: 32 EYRLGPLLGKGGFGTVFAGHRLTDR-----LQVAIKVIPRN--RVLGWSPLSDSVTCPLE 84 Query: 96 IQKWIRT-RKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTV 154 + + + GV + + + DL Y Sbjct: 85 VALLWKVGAGGGHPGVIRLLDW--FETQEGFMLVLERPLPAQDLFD-YITEKGPLGEGPS 141 Query: 155 LQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYK 214 +++ +++ H VH DIK N+L++ + L+D+G E Sbjct: 142 RCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCA-KLIDFGSGALLHDE------- 193 Query: 215 EDPKRCHDGTIEFTSID-AHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRD 273 P DGT ++ + + + LG + + G +P+E + + + Sbjct: 194 --PYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEILEAELH 251 Query: 274 SKIRYRENIASLMDKCFPEKNKPGEIAKYMET 305 + +L+ +C K P E Sbjct: 252 FPAHVSPDCCALIRRCLAPK--PSSRPSLEEI 281 >6NT9-A nrPDB Length = 742 Score = 114 bits (285), Expect = 6e-26, Method: Composition-based stats. Identities = 40/239 (16%), Positives = 76/239 (31%), Gaps = 34/239 (14%) Query: 37 WKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQI 96 W + +GQG ++ + + +KV F + F + Q+ Sbjct: 9 WLLSDILGQGATANVFRGRHKKTGDL-----FAIKV--------FNNISFLRPVDV--QM 53 Query: 97 QKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYE-ANAKRFSRKTVL 155 +++ +KL + + K + M GS + E +NA L Sbjct: 54 REFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFL 113 Query: 156 QLSLRILDILEYIHEHEYVHGDIKASNLL--LNYKNPDQVYLVDYGLAYRYCPEGVHKEY 213 + ++ + ++ E+ VH +IK N++ + L D+G A + Sbjct: 114 IVLRDVVGGMNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFV-- 171 Query: 214 KEDPKRCHDGTIEFTSIDAHNG--------VAPSRRGDLEILGYCMIQWLTGHLPWEDN 264 GT E+ D + DL +G TG LP+ Sbjct: 172 ------SLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPF 224 >4P5Q-A nrPDB Length = 361 Score = 114 bits (285), Expect = 7e-26, Method: Composition-based stats. Identities = 45/286 (15%), Positives = 89/286 (31%), Gaps = 41/286 (14%) Query: 38 KVGLPIGQGGFGCI---YLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPE 94 + +G G FG + L + E + V E + P Sbjct: 36 SIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPN 95 Query: 95 QIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYEANAKRFSRKT 153 I+ GV ++ + L + +F+ Sbjct: 96 IIRLE---------GVVT----------KSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQ 136 Query: 154 VLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEY 213 ++ + I ++Y+ + YVH D+ A N+L+N + D+GL+ + Sbjct: 137 LVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVC--KVSDFGLSRVLEDDPEAAYT 194 Query: 214 KEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQ-WLTGHLPWEDNLKDPKYVR 272 K I +TS +A + D+ G + + G P+ + + + ++ Sbjct: 195 TRGGKI----PIRWTSPEAIAYRKFTSASDVWSYGIVLWEVMSYGERPYWE-MSNQDVIK 249 Query: 273 DSKIRYRENI--------ASLMDKCFPEKNKPGEIAKYMETVKLLD 310 YR LM C+ + K+ + V +LD Sbjct: 250 AVDEGYRLPPPMDCPAALYQLMLDCWQKDR--NNRPKFEQIVSILD 293 >5LPZ-A nrPDB Length = 332 Score = 114 bits (285), Expect = 7e-26, Method: Composition-based stats. Identities = 63/337 (18%), Positives = 122/337 (36%), Gaps = 43/337 (12%) Query: 43 IGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRT 102 IG GGFG +Y A + +V +K +G E + + Sbjct: 25 IGSGGFGDVYKAILKDGSAVA------IKKLIHVSGQGDREF-----------MAEMETI 67 Query: 103 RKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFG-SDLQKIYEANAK---RFSRKTVLQLS 158 K+K+ + G R ++ + L+ + K + + T +++ Sbjct: 68 GKIKHRNLVPLLGY----CKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIA 123 Query: 159 LRILDILEYIHEH---EYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKE 215 + L ++H + +H D+K+SN+LL+ + + D+G+A H Sbjct: 124 IGSARGLAFLHHNCSPHIIHRDMKSSNVLLDENL--EARVSDFGMARLMSAMDTHLSVS- 180 Query: 216 DPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWE-DNLKDPKYVRDS 274 GT + + + S +GD+ G +++ LTG P + + D V Sbjct: 181 ----TLAGTPGYVPPEYYQSFRCSTKGDVYSYGVVLLELLTGKRPTDSPDFGDNNLVGWV 236 Query: 275 KIRYRENIASLMDKCFPEKNKPGEIAKYMET---VKLLD--YTEKPLYENLRDILLQGLK 329 K + I+ + D +++ EI V LD +P + + + Sbjct: 237 KQHAKLRISDVFDPELMKEDPALEIELLQHLKVAVACLDDRAWRRPTMVQVMAMFKEI-- 294 Query: 330 AIGSKDDGKLDLSVVENGGLKAKTITKKRKKEIEESK 366 GS D + + +E+GG + KE+ E K Sbjct: 295 QAGSGIDSQSTIRSIEDGGFSTIEMVDMSIKEVPEGK 331 >4FL3-A nrPDB Length = 635 Score = 114 bits (284), Expect = 8e-26, Method: Composition-based stats. Identities = 49/300 (16%), Positives = 97/300 (32%), Gaps = 46/300 (15%) Query: 41 LPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSD---NGPLFTELKFYQRAAKPEQIQ 97 +G G FG + + V + A ++K E +D L E Q+ P ++ Sbjct: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 Query: 98 KWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQL 157 ++ M M G L K + N + K +++L Sbjct: 435 MIGICEAESWM------------------LVMEMAELGP-LNKYLQQN-RHVKDKNIIEL 474 Query: 158 SLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDP 217 ++ ++Y+ E +VH D+ A N+LL + D+GL+ + + + + Sbjct: 475 VHQVSMGMKYLEESNFVHRDLAARNVLLVT--QHYAKISDFGLSKALRADENYYKAQTHG 532 Query: 218 KRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQ-WLTGHLPWEDNLKDPKYVRDSKI 276 K +++ + + N S + D+ G M + + G P+ K Sbjct: 533 KW----PVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKG 588 Query: 277 RYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDILLQGLKAIGSKDD 336 + P E+ M D +P + + L+ D Sbjct: 589 E----------RMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVE------LRLRNYYYD 632 >5KMM-A nrPDB Length = 329 Score = 114 bits (284), Expect = 9e-26, Method: Composition-based stats. Identities = 39/325 (12%), Positives = 105/325 (32%), Gaps = 49/325 (15%) Query: 10 GRQSSAKRHL--AEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAP 67 G+ S + H+ Q+ + + +++ + +G+G FG ++LA+ ++ Sbjct: 8 GKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKML 67 Query: 68 CVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYR 127 VK + + + ++ L++ + +++G Sbjct: 68 VAVKALKEASESARQDFQ-----------REAELLTMLQHQHIVRFFGV----CTEGRPL 112 Query: 128 FMIMDRFG-SDLQKIYEANAK--------------RFSRKTVLQLSLRILDILEYIHEHE 172 M+ + DL + ++ +L ++ ++ + Y+ Sbjct: 113 LMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLH 172 Query: 173 YVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDA 232 +VH D+ N L+ V + D+G++ ++ I + ++ Sbjct: 173 FVHRDLATRNCLVGQGL--VVKIGDFGMSRDIYSTDYYRVGGRTML-----PIRWMPPES 225 Query: 233 HNGVAPSRRGDLEILGYCMIQ-WLTGHLPWEDNLKDPKYVRDSKIRYRENI-------AS 284 + D+ G + + + G PW ++ R E + Sbjct: 226 ILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYA 285 Query: 285 LMDKCFPEKNKPGEIAKYMETVKLL 309 +M C+ + +P + + L Sbjct: 286 IMRGCW--QREPQQRHSIKDVHARL 308 >5GNK-A nrPDB Length = 297 Score = 114 bits (284), Expect = 1e-25, Method: Composition-based stats. Identities = 45/279 (16%), Positives = 92/279 (32%), Gaps = 33/279 (11%) Query: 20 AEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGP 79 A A+ I+ + E+K +G G FG +Y + ++ + + Sbjct: 7 APNQALLRILKET---EFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPK 63 Query: 80 LFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQ 139 E+ + + + V + G L M + FG L Sbjct: 64 ANKEI-----------LDEAYVMASVDNPHVCRLLGICL---TSTVQLIMQLMPFGCLL- 108 Query: 140 KIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYG 199 + + +L ++I + Y+ + VH D+ A N+L+ K P V + D+G Sbjct: 109 DYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLV--KTPQHVKITDFG 166 Query: 200 LAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT-GH 258 LA E + I++ ++++ + + D+ G + + +T G Sbjct: 167 LAKLLGAEEKEYHAEGGKV-----PIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGS 221 Query: 259 LPWEDNLKDPKYVRDSKIRYRENI-------ASLMDKCF 290 P++ K +M KC+ Sbjct: 222 KPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCW 260 >5LPV-A nrPDB Length = 296 Score = 113 bits (283), Expect = 1e-25, Method: Composition-based stats. Identities = 42/225 (18%), Positives = 83/225 (36%), Gaps = 35/225 (15%) Query: 43 IGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRT 102 IG GGFG +Y A + +V +K +G E + + Sbjct: 25 IGSGGFGDVYKAILKDGSAVA------IKKLIHVSGQGDREF-----------MAEMETI 67 Query: 103 RKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFG-SDLQKIYEANAK---RFSRKTVLQLS 158 K+K+ + G R ++ + L+ + K + + T +++ Sbjct: 68 GKIKHRNLVPLLGY----CKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIA 123 Query: 159 LRILDILEYIHEH---EYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKE 215 + L ++H + +H D+K+SN+LL+ + + D+G+A H Sbjct: 124 IGSARGLAFLHHNCSPHIIHRDMKSSNVLLDENL--EARVSDFGMARLMSAMDTHLSVS- 180 Query: 216 DPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLP 260 GT + + + S +GD+ G +++ LTG P Sbjct: 181 ----TLAGTPGYVPPEYYQSFRCSTKGDVYSYGVVLLELLTGKRP 221 >2Y6O-A nrPDB Length = 291 Score = 113 bits (283), Expect = 1e-25, Method: Composition-based stats. Identities = 48/286 (16%), Positives = 92/286 (32%), Gaps = 41/286 (14%) Query: 38 KVGLPIGQGGFGCIYLADMN---SSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPE 94 K+ IG G FG + + E + +E + P Sbjct: 17 KIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHPN 76 Query: 95 QIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYEANAKRFSRKT 153 I K K + +I + L N RF+ Sbjct: 77 IIHLEGVVTKCKPV-------------------MIITEYMENGSLDAFLRKNDGRFTVIQ 117 Query: 154 VLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEY 213 ++ + I ++Y+ + YVH D+ A N+L+N + D+G++ + Sbjct: 118 LVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVC--KVSDFGMSRVLEDDPEAAYT 175 Query: 214 KEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQ-WLTGHLPWEDNLKDPKYVR 272 K I +T+ +A + D+ G M + G P+ D + + ++ Sbjct: 176 TRGGKI----PIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWD-MSNQDVIK 230 Query: 273 DSKIRYRENIA--------SLMDKCFPEKNKPGEIAKYMETVKLLD 310 + YR LM C+ ++ + K+ + V +LD Sbjct: 231 AIEEGYRLPPPMDCPIALHQLMLDCWQKER--SDRPKFGQIVNMLD 274 >5FM2-A nrPDB Length = 355 Score = 113 bits (282), Expect = 1e-25, Method: Composition-based stats. Identities = 50/294 (17%), Positives = 117/294 (39%), Gaps = 27/294 (9%) Query: 35 KEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKV-----EPSDNGPLFTELKFYQR 89 K +G +G+G FG + A + VK+ PS+ L +E ++ Sbjct: 64 KNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQ 123 Query: 90 AAKPEQIQKWIR-TRKLKYLGVPKY--WGS--GLHDKNGKSYRFMIMDRFGSDLQKIYEA 144 P I+ + ++ L + +Y +GS G ++ K + + + Sbjct: 124 VNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHP 183 Query: 145 NAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRY 204 + + + ++ + +I ++Y+ E + VH D+ A N+L+ ++ + D+GL+ Sbjct: 184 DERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGR--KMKISDFGLSRDV 241 Query: 205 CPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT-GHLPWED 263 E + + + +++ +I++ + + D+ G + + +T G P+ Sbjct: 242 YEEDSYVKRSQGRI-----PVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPG 296 Query: 264 -------NLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLD 310 NL + + E + LM +C+ K +P + + + K L+ Sbjct: 297 IPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCW--KQEPDKRPVFADISKDLE 348 >4Y93-A nrPDB Length = 446 Score = 113 bits (282), Expect = 1e-25, Method: Composition-based stats. Identities = 41/271 (15%), Positives = 86/271 (31%), Gaps = 41/271 (15%) Query: 41 LPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWI 100 +G G FG + V +K E K + + +Q Sbjct: 194 KELGTGQFGVVKYGKWRGQYDVAIKM---IKEGSMSEDEFIEEAKVMMNLSHEKLVQ--- 247 Query: 101 RTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYEANAKRFSRKTVLQLSL 159 +G + F+I + L RF + +L++ Sbjct: 248 ------------LYGVCTKQRP----IFIITEYMANGCLLNYLREMRHRFQTQQLLEMCK 291 Query: 160 RILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKR 219 + + +EY+ +++H D+ A N L+N + V + D+G+ + Sbjct: 292 DVCEAMEYLESKQFLHRDLAARNCLVN--DQGVVKVSDFGMTRYVLDDE------YTSST 343 Query: 220 CHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT-GHLPWEDNLKDPKYVRDSKIRY 278 +++ S + S + D+ G M + + G +P+E ++ Sbjct: 344 GSKFPVKWASPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLR 403 Query: 279 -------RENIASLMDKCFPEKNKPGEIAKY 302 E + ++M C+ EK E + Sbjct: 404 LPRPHLASERVYAIMYSCWHEKA--DERPTF 432 >1FVR-A nrPDB Length = 327 Score = 113 bits (282), Expect = 1e-25, Method: Composition-based stats. Identities = 47/308 (15%), Positives = 104/308 (33%), Gaps = 58/308 (18%) Query: 38 KVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVK--VEPSDNGPLFTELKFYQRAAKPEQ 95 K IG+G FG + A + A +K D+ EL+ + Sbjct: 28 KFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGH--- 84 Query: 96 IQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDR--FGSDLQKIY----------- 142 + + G+ H + Y ++ ++ G+ L + Sbjct: 85 -----------HPNIINLLGACEH----RGYLYLAIEYAPHGNLLDFLRKSRVLETDPAF 129 Query: 143 ---EANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYG 199 + A S + +L + + ++Y+ + +++H D+ A N+L+ + D+G Sbjct: 130 AIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGEN--YVAKIADFG 187 Query: 200 LAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT-GH 258 L+ + + + +I++ N + D+ G + + ++ G Sbjct: 188 LSRGQEVYVKKTMGRL--------PVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGG 239 Query: 259 LPWEDNLKDPKYVRDSKIRYRENI-------ASLMDKCFPEKNKPGEIAKYMETVKLLD- 310 P+ Y + + E LM +C+ EK P E + + + L+ Sbjct: 240 TPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREK--PYERPSFAQILVSLNR 297 Query: 311 -YTEKPLY 317 E+ Y Sbjct: 298 MLEERKTY 305 >3BEA-A nrPDB Length = 333 Score = 113 bits (281), Expect = 2e-25, Method: Composition-based stats. Identities = 52/292 (17%), Positives = 104/292 (35%), Gaps = 33/292 (11%) Query: 35 KEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPS-----DNGPLFTELKFYQR 89 + G +G G FG + A + VK+ S + L +ELK Sbjct: 46 NNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSH 105 Query: 90 AAKPEQIQKWIR--TRKLKYLGVPKYWGSG-LHDKNGKSYRFMIMDRFGSDLQKIYEANA 146 + E I + T L + +Y G L + + R + D + Sbjct: 106 LGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKSRVLETDP-------AFAIAN 158 Query: 147 KRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCP 206 S + +L S ++ + ++ +H D+ A N+LL N + D+GLA Sbjct: 159 STLSTRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLT--NGHVAKIGDFGLARDIMN 216 Query: 207 EGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT-GHLPWEDNL 265 + + K +++ + ++ + + D+ G + + + G P+ L Sbjct: 217 DSNYI-----VKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGIL 271 Query: 266 KDPKYVRDSKIRYR--------ENIASLMDKCFPEKNKPGEIAKYMETVKLL 309 + K+ + K Y+ +NI S+M C+ + P + + L Sbjct: 272 VNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALE--PTHRPTFQQICSFL 321 >5C26-A nrPDB Length = 299 Score = 113 bits (281), Expect = 2e-25, Method: Composition-based stats. Identities = 49/300 (16%), Positives = 97/300 (32%), Gaps = 46/300 (15%) Query: 41 LPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSD---NGPLFTELKFYQRAAKPEQIQ 97 +G G FG + + V + A ++K E +D L E Q+ P ++ Sbjct: 33 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 92 Query: 98 KWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQL 157 ++ M M G L K + N + K +++L Sbjct: 93 MIGICEAESWM------------------LVMEMAELGP-LNKYLQQN-RHVKDKNIIEL 132 Query: 158 SLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDP 217 ++ ++Y+ E +VH D+ A N+LL + D+GL+ + + + + Sbjct: 133 VHQVSMGMKYLEESNFVHRDLAARNVLLVT--QHYAKISDFGLSKALRADENYYKAQTHG 190 Query: 218 KRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQ-WLTGHLPWEDNLKDPKYVRDSKI 276 K +++ + + N S + D+ G M + + G P+ K Sbjct: 191 KW----PVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKG 246 Query: 277 RYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDILLQGLKAIGSKDD 336 + P E+ M D +P + + L+ D Sbjct: 247 E----------RMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVE------LRLRNYYYD 290 >5TOS-A nrPDB Length = 395 Score = 113 bits (281), Expect = 2e-25, Method: Composition-based stats. Identities = 59/319 (18%), Positives = 118/319 (36%), Gaps = 41/319 (12%) Query: 32 MAKKEWKVGLPIGQGGFGCIYLADMNSSESV----GSDAPCVVKVEPSDNGPLFTELKFY 87 +A + ++ IG+GGFGC++ ++ S G+ VK + E Sbjct: 62 LATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREW--- 118 Query: 88 QRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF--GSDLQKIYEAN 145 + + +L + + K G L D++ R ++ + GS ++ Sbjct: 119 --------LTEINYLGQLSHPNLVKLIGYCLEDEH----RLLVYEFMQKGSLENHLFRRG 166 Query: 146 A--KRFSRKTVLQLSLRILDILEYIHEH--EYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 A K + ++L L ++H + ++ DIKASN+LL+ L D+GLA Sbjct: 167 AYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDAD--YNAKLSDFGLA 224 Query: 202 YRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPW 261 +G + R GT + + + + + R D+ G +++ L+G Sbjct: 225 R----DGPMGDLSYVSTRVM-GTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRAL 279 Query: 262 EDNLKDPKYVRDSKIRY-----RENIASLMDKCFPEKNKPGEIAKYMET-VKLLDYTEK- 314 + N + + + ++D + P E + V+ L + K Sbjct: 280 DHNRPAKE-ENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKS 338 Query: 315 -PLYENLRDILLQGLKAIG 332 P + + L Q +G Sbjct: 339 RPTMDQVVRALQQLQDNLG 357 >2A1A-B nrPDB Length = 284 Score = 113 bits (281), Expect = 2e-25, Method: Composition-based stats. Identities = 58/297 (19%), Positives = 105/297 (35%), Gaps = 27/297 (9%) Query: 26 GEIITDM-AKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTEL 84 G D ++K IG GGFG ++ A V+K +N E+ Sbjct: 1 GAHTVDKRFGMDFKEIELIGSGGFGQVFKAKHR-----IDGKTYVIKRVKYNNEKAEREV 55 Query: 85 KFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF--GSDLQKIY 142 K + + Y S ++ F+ M+ G+ Q I Sbjct: 56 KALAKLDHVNIVHYNGCWDGFDY---DPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIE 112 Query: 143 EANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAY 202 + ++ + L+L +I ++YIH + ++ D+K SN+ L + QV + D+GL Sbjct: 113 KRRGEKLDKVLALELFEQITKGVDYIHSKKLINRDLKPSNIFLV--DTKQVKIGDFGLVT 170 Query: 203 RYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWL-TGHLPW 261 +G K GT+ + S + + + DL LG + + L + Sbjct: 171 SLKNDGKRTRSK--------GTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAF 222 Query: 262 EDN--LKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPL 316 E + D + S I ++ L KP + E ++ L +K Sbjct: 223 ETSKFFTDLRDGIISDIFDKKEKTLLQKL---LSKKPEDRPNTSEILRTLTVWKKSP 276 >4E20-A nrPDB Length = 290 Score = 113 bits (281), Expect = 2e-25, Method: Composition-based stats. Identities = 55/309 (17%), Positives = 106/309 (34%), Gaps = 40/309 (12%) Query: 30 TDMAKKEW-KVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQ 88 + K + K +G+G FG + L + G+ VK GP Sbjct: 2 PTVFHKRYLKKIRDLGEGHFGKVSL-YCYDPTNDGTGEMVAVKALKEGCGPQL------- 53 Query: 89 RAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYEANAK 147 + ++ R L + + KY G + G+ ++M+ L+ + Sbjct: 54 ---RSGWQREIEILRTLYHEHIVKYKGC--CEDQGEKSVQLVMEYVPLGSLRDYLPRHCV 108 Query: 148 RFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPE 207 +L + +I + + Y+H Y+H + A N+LL+ V + D+GLA Sbjct: 109 GL--AQLLLFAQQICEGMAYLHAQHYIHRALAARNVLLDNDR--LVKIGDFGLAKAVPEG 164 Query: 208 GVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT----GHLPWED 263 + +ED + + + D+ G + + LT P Sbjct: 165 HEYYRVREDGDSPVF----WYAPECLKECKFYYASDVWSFGVTLYELLTYCDSNQSPHTK 220 Query: 264 NLK-------DPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPL 316 + +R +++ R D+C P EI M+ + + +P Sbjct: 221 FTELIGHTQGQMTVLRLTELLERGERLPRPDRC------PCEIYHLMKNCWETEASFRPT 274 Query: 317 YENLRDILL 325 ++NL IL Sbjct: 275 FQNLVPILQ 283 >3KRL-A nrPDB Length = 335 Score = 113 bits (281), Expect = 2e-25, Method: Composition-based stats. Identities = 46/298 (15%), Positives = 95/298 (31%), Gaps = 43/298 (14%) Query: 35 KEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPE 94 + G +G G FG + A + VK+ S E + Sbjct: 46 NNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSH 105 Query: 95 QIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAK------- 147 Q + + G+ H G +G L + Sbjct: 106 LGQ---------HENIVNLLGACTHG--GPVLVITEYCCYGDLLNFLRRKRPPGLEYSYN 154 Query: 148 -------RFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGL 200 + S + +L S ++ + ++ +H D+ A N+LL N + D+GL Sbjct: 155 PSHNPEEQLSSRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLT--NGHVAKIGDFGL 212 Query: 201 AYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT-GHL 259 A + + K +++ + ++ + + D+ G + + + G Sbjct: 213 ARDIMNDSNYI-----VKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLN 267 Query: 260 PWEDNLKDPKYVRDSKIRYR--------ENIASLMDKCFPEKNKPGEIAKYMETVKLL 309 P+ L + K+ + K Y+ +NI S+M C+ + P + + L Sbjct: 268 PYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALE--PTHRPTFQQICSFL 323 >5L6P-A nrPDB Length = 298 Score = 112 bits (280), Expect = 2e-25, Method: Composition-based stats. Identities = 56/308 (18%), Positives = 95/308 (30%), Gaps = 41/308 (13%) Query: 17 RHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNS---SESVGSDAPCVVKVE 73 AV E ++ K+ IG G FG + + E + V Sbjct: 1 GSSDPNEAVREFAKEIDVSCVKIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYT 60 Query: 74 PSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDR 133 +E + P I+ L KS MI+ Sbjct: 61 ERQRRDFLSEASIMGQFDHPNIIR--------------------LEGVVTKSRPVMILTE 100 Query: 134 F--GSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPD 191 F L N +F+ ++ + I ++Y+ E YVH D+ A N+L+N Sbjct: 101 FMENCALDSFLRLNDGQFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVC 160 Query: 192 QVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCM 251 + D+GL+ + Y I +T+ +A + D+ G M Sbjct: 161 --KVSDFGLSRFLEDDPSDPTYT--SSLGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVM 216 Query: 252 IQ-WLTGHLPWEDNLKDPKYVRDSKIRYRENIA--------SLMDKCFPEKNKPGEIAKY 302 + G P+ D + + + + YR LM C+ K+ Sbjct: 217 WEVMSYGERPYWD-MSNQDVINAVEQDYRLPPPMDCPTALHQLMLDCWVRDR--NLRPKF 273 Query: 303 METVKLLD 310 + V LD Sbjct: 274 SQIVNTLD 281 >1BYG-A nrPDB Length = 278 Score = 112 bits (280), Expect = 3e-25, Method: Composition-based stats. Identities = 56/315 (17%), Positives = 113/315 (35%), Gaps = 48/315 (15%) Query: 16 KRHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPS 75 +A Q + KE K+ IG+G FG + L D ++ VK + Sbjct: 2 GGSVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNK-------VAVKCIKN 54 Query: 76 DNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFG 135 D T F A+ Q++ + + + G + +K G +++ + Sbjct: 55 DA----TAQAFLAEASVMTQLR---------HSNLVQLLGVIVEEKGG---LYIVTEYMA 98 Query: 136 -SDLQKIYEANAKR-FSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQV 193 L + + +L+ SL + + +EY+ + +VH D+ A N+L++ N Sbjct: 99 KGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDN--VA 156 Query: 194 YLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQ 253 + D+GL + +++T+ +A S + D+ G + + Sbjct: 157 KVSDFGLTKEASSTQDTGKLP----------VKWTAPEALREKKFSTKSDVWSFGILLWE 206 Query: 254 WLT-GHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYT 312 + G +P+ R K Y+ + P + + M+ LD Sbjct: 207 IYSFGRVPYPRIPLKDVVPRVEK-GYKMDAPD---------GCPPAVYEVMKNCWHLDAA 256 Query: 313 EKPLYENLRDILLQG 327 +P + LR+ L Sbjct: 257 MRPSFLQLREQLEHI 271 >4F0G-A nrPDB Length = 287 Score = 112 bits (280), Expect = 3e-25, Method: Composition-based stats. Identities = 45/288 (15%), Positives = 96/288 (33%), Gaps = 45/288 (15%) Query: 41 LPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWI 100 IG+GGFG ++ + +SV + ++ + + +F ++ Sbjct: 25 KQIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQ---------REVF 75 Query: 101 RTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYEANAKRFSRKTVLQLSL 159 L + + K +G +H+ M+M+ DL A L+L L Sbjct: 76 IMSNLNHPNIVKLYGL-MHNPPR-----MVMEFVPCGDLYHRLLDKAHPIKWSVKLRLML 129 Query: 160 RILDILEYIHEHE--YVHGDIKASNLLLNYKNPDQ---VYLVDYGLAYRYCPEGVHKEYK 214 I +EY+ VH D+++ N+ L + + + D+GL+ + Sbjct: 130 DIALGIEYMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQ----------S 179 Query: 215 EDPKRCHDGTIEFTSIDAHNGVAPSR--RGDLEILGYCMIQWLTGHLPWEDNLKDP-KYV 271 G ++ + + S + D + LTG P+++ K++ Sbjct: 180 VHSVSGLLGNFQWMAPETIGAEEESYTEKADTYSFAMILYTILTGEGPFDEYSYGKIKFI 239 Query: 272 RDSKIRYRENIAS---------LMDKCFPEKNKPGEIAKYMETVKLLD 310 + +++ C+ P + + VK L Sbjct: 240 NMIREEGLRPTIPEDCPPRLRNVIELCW--SGDPKKRPHFSYIVKELS 285 >3PP0-A nrPDB Length = 338 Score = 112 bits (280), Expect = 3e-25, Method: Composition-based stats. Identities = 54/298 (18%), Positives = 103/298 (34%), Gaps = 39/298 (13%) Query: 20 AEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLAD-MNSSESVGSDAPCVVKVEPSDNG 78 A A+ I+ + ++ KV +G G FG +Y + E+V P +KV Sbjct: 5 APNQALLRILKETELRKVKV---LGSGAFGTVYKGIWIPDGENV--KIPVAIKV------ 53 Query: 79 PLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFG-SD 137 R + K I GV + S L S ++ Sbjct: 54 ---------LRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGC 104 Query: 138 LQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVD 197 L N R + +L ++I + Y+ + VH D+ A N+L+ K+P+ V + D Sbjct: 105 LLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLV--KSPNHVKITD 162 Query: 198 YGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT- 256 +GLA + I++ ++++ + + D+ G + + +T Sbjct: 163 FGLARLLDIDETEYHADGGKV-----PIKWMALESILRRRFTHQSDVWSYGVTVWELMTF 217 Query: 257 GHLPWEDNLKDPKYVRDSKIRYRENI-------ASLMDKCFPEKNKPGEIAKYMETVK 307 G P++ K +M KC+ ++ ++ E V Sbjct: 218 GAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSEC--RPRFRELVS 273 >4LRM-A nrPDB Length = 334 Score = 112 bits (279), Expect = 3e-25, Method: Composition-based stats. Identities = 51/291 (17%), Positives = 93/291 (31%), Gaps = 42/291 (14%) Query: 14 SAKRHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLAD-MNSSESVGSDAPCVVK- 71 + A A+ I+ + E+K +G G FG +Y + E V P +K Sbjct: 1 GSPSGEAPNQALLRILKET---EFKKIKVLGSGAFGTVYKGLWIPEGEKV--KIPVAIKE 55 Query: 72 ----VEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYR 127 P N + E P V + G L Sbjct: 56 LREATSPKANKEILDEAYVMASVDNP------------GNPHVCRLLGICL---TSTVQL 100 Query: 128 FMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY 187 + FG L + + +L ++I + Y+ + VH D+ A N+L+ Sbjct: 101 ITQLMPFGCLL-DYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLV-- 157 Query: 188 KNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEIL 247 K P V + D+GLA E + I++ ++++ + + D+ Sbjct: 158 KTPQHVKITDFGLAKLLGAEEKEYHAEGGKV-----PIKWMALESILHRIYTHQSDVWSY 212 Query: 248 GYCMIQWLT-GHLPWEDNLKDPKYVRDSKIRYRENI-------ASLMDKCF 290 G + + +T G P++ K +M KC+ Sbjct: 213 GVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCW 263 >3UIU-A nrPDB Length = 306 Score = 112 bits (279), Expect = 3e-25, Method: Composition-based stats. Identities = 57/299 (19%), Positives = 105/299 (35%), Gaps = 33/299 (11%) Query: 33 AKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAK 92 ++K IG GGFG ++ A V++ +N E+K + Sbjct: 10 FGMDFKEIELIGSGGFGQVFKAKHR-----IDGKTYVIRRVKYNNEKAEREVKALAKLDH 64 Query: 93 PEQIQ--------KWIRTRKLKYLGVPKY--WGSGLHDKNGKSYRFMIMDRF--GSDLQK 140 + + L Y S ++ F+ M+ G+ Q Sbjct: 65 VNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQW 124 Query: 141 IYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGL 200 I + ++ + L+L +I ++YIH + +H D+K SN+ L + QV + D+GL Sbjct: 125 IEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLV--DTKQVKIGDFGL 182 Query: 201 AYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWL-TGHL 259 +G K GT+ + S + + + DL LG + + L Sbjct: 183 VTSLKNDGKRTRSK--------GTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDT 234 Query: 260 PWEDN--LKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPL 316 +E + D + S I ++ L KP + E ++ L +K Sbjct: 235 AFETSKFFTDLRDGIISDIFDKKEKTLLQKL---LSKKPEDRPNTSEILRTLTVWKKSP 290 >3RP9-A nrPDB Length = 458 Score = 112 bits (279), Expect = 3e-25, Method: Composition-based stats. Identities = 38/262 (14%), Positives = 78/262 (29%), Gaps = 39/262 (14%) Query: 17 RHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPS 75 +++ IG G +G + A D V V + Sbjct: 35 SSKPTASMPRPHSDWQIPDRYEIRHLIGTGSYGHVCEAYDKLEKRVVAIKKILRVFEDLI 94 Query: 76 DNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFG 135 D + E+ R ++ + +PK D +++++ Sbjct: 95 DCKRILREIAILNRLNHDHVVKVLD-------IVIPK-------DVEKFDELYVVLEIAD 140 Query: 136 SDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYL 195 SD +K++ + + L +L ++Y+H +H D+K +N L+N V + Sbjct: 141 SDFKKLF-RTPVYLTELHIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQD--CSVKV 197 Query: 196 VDYGLAYRYCPEGV--------------------HKEYKEDPKRCHDGTIEFTSIDAHNG 235 D+GLA H + + H T + + + Sbjct: 198 CDFGLARTVDYPENGNSQLPISPREDDMNLVTFPHTKNLKRQLTGHVVTRWYRAPELILL 257 Query: 236 VAPSRRG-DLEILGYCMIQWLT 256 D+ +G + L Sbjct: 258 QENYTEAIDVWSIGCIFAELLN 279 >4XI2-A nrPDB Length = 446 Score = 112 bits (279), Expect = 3e-25, Method: Composition-based stats. Identities = 43/299 (14%), Positives = 93/299 (31%), Gaps = 56/299 (18%) Query: 41 LPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWI 100 +G G FG + V ++ E K + + +Q Sbjct: 193 KELGTGQFGVVKYGKWRGQYDVAIKM---IREGSMSEDEFIEEAKVMMNLSHEKLVQ--- 246 Query: 101 RTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYEANAKRFSRKTVLQLSL 159 +G + F+I + L RF + +L++ Sbjct: 247 ------------LYGVCTKQRP----IFIITEYMANGCLLNYLREMRHRFQTQQLLEMCK 290 Query: 160 RILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKR 219 + + +EY+ +++H D+ A N L+N + V + D+GL+ + Sbjct: 291 DVCEAMEYLESKQFLHRDLAARNCLVN--DQGVVKVSDFGLSRYVLDDE------YTSSV 342 Query: 220 CHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT-GHLPWEDNLKDPKYVRDSKIRY 278 + ++ + S + D+ G M + + G +P+E ++ Sbjct: 343 GSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLR 402 Query: 279 -------RENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDILLQGLKA 330 E + ++M C+ EK E+P ++ L +L + Sbjct: 403 LYRPHLASERVYTIMYSCWHEKA-----------------DERPSFKILLSNILDVMDE 444 >2R2P-A nrPDB Length = 295 Score = 112 bits (279), Expect = 4e-25, Method: Composition-based stats. Identities = 50/309 (16%), Positives = 102/309 (33%), Gaps = 41/309 (13%) Query: 15 AKRHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMN-SSESVGSDAPCVVKVE 73 + AV E ++ + IG G FG + + + A +KV Sbjct: 2 PHTYEDPNQAVHEFAKEIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVG 61 Query: 74 PSDNGP--LFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIM 131 ++ E + P I +L ++ Sbjct: 62 YTEKQRRDFLGEASIMGQFDHPNII----------HLEGVV---------TKSKPVMIVT 102 Query: 132 DRF-GSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNP 190 + L + N +F+ ++ + I ++Y+ + YVH D+ A N+L+N Sbjct: 103 EYMENGSLDTFLKKNDGQFTVIQLVGMLRGISAGMKYLSDMGYVHRDLAARNILINSNLV 162 Query: 191 DQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYC 250 + D+GL+ + K I +T+ +A + D+ G Sbjct: 163 C--KVSDFGLSRVLEDDPEAAYTTRGGKI----PIRWTAPEAIAFRKFTSASDVWSYGIV 216 Query: 251 MIQWL-TGHLPWEDNLKDPKYVRDSKIRYREN--------IASLMDKCFPEKNKPGEIAK 301 M + + G P+ + + + ++ + YR + LM C+ ++ K Sbjct: 217 MWEVVSYGERPYWE-MTNQDVIKAVEEGYRLPSPMDCPAALYQLMLDCWQKERNS--RPK 273 Query: 302 YMETVKLLD 310 + E V +LD Sbjct: 274 FDEIVNMLD 282 >1K9A-A nrPDB Length = 450 Score = 111 bits (278), Expect = 4e-25, Method: Composition-based stats. Identities = 48/287 (16%), Positives = 103/287 (35%), Gaps = 47/287 (16%) Query: 34 KKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKP 93 KE K+ IG+G FG + L D ++ VK +D T F A+ Sbjct: 192 MKELKLLQTIGKGEFGDVMLGDYRGNK-------VAVKCIKNDA----TAQAFLAEASVM 240 Query: 94 EQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFG-SDLQKIYEANAKR-FSR 151 Q++ + + + G + +K G +++ + L + + Sbjct: 241 TQLR---------HSNLVQLLGVIVEEKGG---LYIVTEYMAKGSLVDYLRSRGRSVLGG 288 Query: 152 KTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHK 211 +L+ SL + + +EY+ + +VH D+ A N+L++ N + D+GL Sbjct: 289 DCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDN--VAKVSDFGLTKEASSTQDTG 346 Query: 212 EYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT-GHLPWEDNLKDPKY 270 + +++T+ +A S + D+ G + + + G +P+ Sbjct: 347 KLP----------VKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVV 396 Query: 271 VRDSKIRYRENI-------ASLMDKCFPEKNKPGEIAKYMETVKLLD 310 R K + +M C+ +++ + L+ Sbjct: 397 PRVEKGYKMDAPDGCPPAVYDVMKNCWHLDA--ATRPTFLQLREQLE 441 >3LZB-A nrPDB Length = 327 Score = 111 bits (278), Expect = 4e-25, Method: Composition-based stats. Identities = 44/279 (15%), Positives = 91/279 (32%), Gaps = 33/279 (11%) Query: 20 AEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGP 79 A A+ I+ + E+K +G G FG +Y + ++ + + Sbjct: 3 APNQALLRILKET---EFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPK 59 Query: 80 LFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQ 139 E+ + + + V + G L + FG L Sbjct: 60 ANKEI-----------LDEAYVMASVDNPHVCRLLGICL---TSTVQLITQLMPFGCLL- 104 Query: 140 KIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYG 199 + + +L ++I + Y+ + VH D+ A N+L+ K P V + D+G Sbjct: 105 DYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLV--KTPQHVKITDFG 162 Query: 200 LAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT-GH 258 LA E + I++ ++++ + + D+ G + + +T G Sbjct: 163 LAKLLGAEEKEYHAEGGKV-----PIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGS 217 Query: 259 LPWEDNLKDPKYVRDSKIRYRENI-------ASLMDKCF 290 P++ K +M KC+ Sbjct: 218 KPYDGIPASEISSILEKGERLPQPPICTIDVYMIMRKCW 256 >5UV4-A nrPDB Length = 311 Score = 111 bits (278), Expect = 4e-25, Method: Composition-based stats. Identities = 48/252 (19%), Positives = 96/252 (38%), Gaps = 34/252 (13%) Query: 97 QKWIRTRKLKYLGVPK----YWGSGLHDKNGKSYRFMIMDR-----FGSDLQKIYEANAK 147 ++ + +++ + YWG H+ R MI D + L + E N Sbjct: 70 REIKKLGSVRHPNLVPLRGYYWGPKEHE------RIMISDYADATSLSTYLSEFDERNLP 123 Query: 148 RFSRKTVLQLSLRILDILEYIHEHEYV-HGDIKASNLLLNYKNPDQVYLVDYGLAYRYCP 206 S L +++ I L+Y+H + HG+IK+SN+L+ P + + DY L P Sbjct: 124 PLSAGQRLNIAIDIARCLDYLHNERVIPHGNIKSSNVLIQNSTPSAL-VTDYSLHRLMTP 182 Query: 207 EGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLK 266 G+ ++ + EF+S + PS + D+ G +++ LTG + E Sbjct: 183 IGMAEQVLNAGALGYS-PPEFSST---SKPCPSLKSDVYAFGVILLELLTGKIAGEIICM 238 Query: 267 DPKYVRDSKIRYRENIASLMDKCF--------PEKNKPGEIAKYMETVKLL--DYTEKPL 316 + V + ++ + +C+ + P + + +E+P Sbjct: 239 NDGVVDLTDWVRMLDLEERVSECYDRHITGVESSEGAPQALDGMLRIALRCIRSASERPE 298 Query: 317 YENLRDILLQGL 328 +R + L Sbjct: 299 ---VRTVFEDLL 307 >1JPA-A nrPDB Length = 312 Score = 111 bits (277), Expect = 6e-25, Method: Composition-based stats. Identities = 52/287 (18%), Positives = 90/287 (31%), Gaps = 41/287 (14%) Query: 38 KVGLPIGQGGFGCI---YLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPE 94 K+ IG G FG + +L E + +E + P Sbjct: 36 KIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPN 95 Query: 95 QIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF--GSDLQKIYEANAKRFSRK 152 I L KS MI+ F L N +F+ Sbjct: 96 VIH--------------------LEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVI 135 Query: 153 TVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKE 212 ++ + I ++Y+ + YVH D+ A N+L+N + D+GL+ + Sbjct: 136 QLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVC--KVSDFGLSRFLEDDTSDPT 193 Query: 213 YKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQ-WLTGHLPWEDNLKDPKYV 271 Y I +T+ +A + D+ G M + G P+ D + + + Sbjct: 194 YT--SALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWD-MTNQDVI 250 Query: 272 RDSKIRYRENIA--------SLMDKCFPEKNKPGEIAKYMETVKLLD 310 + YR LM C+ + K+ + V LD Sbjct: 251 NAIEQDYRLPPPMDCPSALHQLMLDCWQKDR--NHRPKFGQIVNTLD 295 >5J0A-A nrPDB Length = 300 Score = 111 bits (277), Expect = 6e-25, Method: Composition-based stats. Identities = 52/275 (18%), Positives = 104/275 (37%), Gaps = 25/275 (9%) Query: 41 LPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWI 100 +G G +YL S + V K+ P N Q + Sbjct: 15 QKLGFGTGVNVYLMK-RSPRGLSHSPWAVKKINPICNDHY----------RSVYQKRLMD 63 Query: 101 RTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGS-----DLQKIYEANAKRFSRKTVL 155 + LK L P G + + M+ G +++ Y+A+ F +L Sbjct: 64 EAKILKSLHHPNIVGYRAFTEANDGSLCLAMEYGGEKSLNDLIEERYKASQDPFPAAIIL 123 Query: 156 QLSLRILDILEYIH-EHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYK 214 +++L + L+Y+H E + +HGDIK+SN+++ + + + + D G++ P + E Sbjct: 124 KVALNMARGLKYLHQEKKLLHGDIKSSNVVI-KGDFETIKICDVGVS---LPLDENMEV- 178 Query: 215 EDPKRCHDGTIEFTSIDAHNGVAP-SRRGDLEILGYCMIQWLTGHLPWED--NLKDPKYV 271 DP+ C+ GT + +A + + D+ G + + +T +P + N D + Sbjct: 179 TDPEACYIGTEPWKPKEAVEENGVITDKADIFAFGLTLWEMMTLSIPHINLSNDDDDEDK 238 Query: 272 RDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETV 306 + + + P N Y + + Sbjct: 239 TFDESDFDDEAYYAALGTRPPINMEELDESYQKVI 273 >3BBT-B nrPDB Length = 328 Score = 111 bits (276), Expect = 7e-25, Method: Composition-based stats. Identities = 57/280 (20%), Positives = 105/280 (37%), Gaps = 35/280 (12%) Query: 20 AEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLAD-MNSSESVGSDAPCVVKVEPSDNG 78 A A I+ + K KV +G G FG +Y + E+V P +K+ G Sbjct: 3 APNQAQLRILKETELKRVKV---LGSGAFGTVYKGIWVPEGETV--KIPVAIKILNETTG 57 Query: 79 PLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDL 138 P A E + + + + + + + G L + M G L Sbjct: 58 P----------KANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLM---PHGCLL 104 Query: 139 QKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDY 198 + + + +L ++I + Y+ E VH D+ A N+L+ K+P+ V + D+ Sbjct: 105 E-YVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLV--KSPNHVKITDF 161 Query: 199 GLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT-G 257 GLA EG KEY D + I++ +++ + + + D+ G + + +T G Sbjct: 162 GLARLL--EGDEKEYNADGGKM---PIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFG 216 Query: 258 HLPWEDNLKDPKYVRDSKIRYRENI-------ASLMDKCF 290 P++ K +M KC+ Sbjct: 217 GKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCW 256 >4E7W-A nrPDB Length = 394 Score = 111 bits (276), Expect = 8e-25, Method: Composition-based stats. Identities = 45/270 (16%), Positives = 83/270 (30%), Gaps = 34/270 (12%) Query: 37 WKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQI 96 + IG G FG ++ A + S+ V +K D EL+ + P + Sbjct: 42 YTNCKVIGNGSFGVVFQAKLVESDEVA------IKKVLQDKRFKNRELQIMRIVKHPNVV 95 Query: 97 QKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKI---YEANAKRFSRKT 153 + Y DK + + ++++ + + Y + Sbjct: 96 ----DLKAFFYSNG---------DKKDEVFLNLVLEYVPETVYRASRHYAKLKQTMPMLL 142 Query: 154 VLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEY 213 + ++L L YIH H DIK NLLL+ + L+D+G A + Y Sbjct: 143 IKLYMYQLLRSLAYIHSIGICHRDIKPQNLLLDPP-SGVLKLIDFGSAKILIAGEPNVSY 201 Query: 214 KEDPKRCHDGTIEFTSIDAHNG-VAPSRRGDLEILGYCMIQWLTGHL--PWEDNLKDPKY 270 + + + G + D+ G M + + G P E + Sbjct: 202 ICSRY--------YRAPELIFGATNYTTNIDIWSTGCVMAELMQGQPLFPGESGIDQLVE 253 Query: 271 VRDSKIRYRENIASLMDKCFPEKNKPGEIA 300 + M+ + E P Sbjct: 254 IIKVLGTPSREQIKTMNPNYMEHKFPQIRP 283 >5AMN-A nrPDB Length = 299 Score = 110 bits (275), Expect = 9e-25, Method: Composition-based stats. Identities = 49/297 (16%), Positives = 112/297 (37%), Gaps = 47/297 (15%) Query: 35 KEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKV-----EPSDNGPLFTELKFYQR 89 K +G +G+G FG + A + VK+ PS+ L +E ++ Sbjct: 23 KNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQ 82 Query: 90 AAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEA----- 144 P I+ G ++G + ++GS + E+ Sbjct: 83 VNHPHVIKL-----------------YGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGP 125 Query: 145 ---NAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 + + + ++ + +I ++Y+ E + VH D+ A N+L+ ++ + D+GL+ Sbjct: 126 GYPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGR--KMKISDFGLS 183 Query: 202 YRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT-GHLP 260 E + + + +++ +I++ + + D+ G + + +T G P Sbjct: 184 RDVYEEDSYVKRSQGRI-----PVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNP 238 Query: 261 WED-------NLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLD 310 + NL + + E + LM +C+ K +P + + + K L+ Sbjct: 239 YPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCW--KQEPDKRPVFADISKDLE 293 >3SXS-A nrPDB Length = 268 Score = 110 bits (275), Expect = 1e-24, Method: Composition-based stats. Identities = 36/281 (12%), Positives = 98/281 (34%), Gaps = 41/281 (14%) Query: 39 VGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQK 98 + +G G FG + L V +K F E + + + P+ Sbjct: 12 LLKELGSGQFGVVKLGKWKGQYDVAVKM---IKEGSMSEDEFFQEAQTMMKLSHPK---- 64 Query: 99 WIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFG-SDLQKIYEANAKRFSRKTVLQL 157 + K++G + +++ + L ++ K +L++ Sbjct: 65 -----------LVKFYGVCSKEYP----IYIVTEYISNGCLLNYLRSHGKGLEPSQLLEM 109 Query: 158 SLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDP 217 + + + ++ H+++H D+ A N L++ V + D+G+ + Sbjct: 110 CYDVCEGMAFLESHQFIHRDLAARNCLVDRDLC--VKVSDFGMTRYVLDDQ------YVS 161 Query: 218 KRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQ-WLTGHLPWEDNLKDPKYVRDSKI 276 +++++ + + S + D+ G M + + G +P++ ++ S+ Sbjct: 162 SVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGILMWEVFSLGKMPYDLYTNSEVVLKVSQG 221 Query: 277 RY-------RENIASLMDKCFPEKNKPGEIAKYMETVKLLD 310 + I +M C+ E P + + + + ++ Sbjct: 222 HRLYRPHLASDTIYQIMYSCWHE--LPEKRPTFQQLLSSIE 260 >4YFF-A nrPDB Length = 311 Score = 110 bits (274), Expect = 1e-24, Method: Composition-based stats. Identities = 40/280 (14%), Positives = 89/280 (31%), Gaps = 34/280 (12%) Query: 40 GLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKW 99 IG G FG +Y + +K + + ++ ++ Sbjct: 47 HEIIGSGSFGKVYKGRCRNK-------IVAIK--------RYRANTYCSKSDVDMFCREV 91 Query: 100 IRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSL 159 +L + V ++ G+ L+D + + G L + + ++ L +++ Sbjct: 92 SILCQLNHPCVIQFVGACLND--PSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAV 149 Query: 160 RILDILEYIHE--HEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDP 217 + +EY+H +H D+ + N+LL + D+G + ED Sbjct: 150 DVAKGMEYLHNLTQPIIHRDLNSHNILLYEDG--HAVVADFGESRFLQS------LDEDN 201 Query: 218 KRCHDGTIEFTSIDAHN-GVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDS-- 274 G + + + + + + D+ C+ + LTG +P+ + Sbjct: 202 MTKQPGNLRWMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYH 261 Query: 275 ----KIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLD 310 I Y P ++ E V L+ Sbjct: 262 HIRPPIGYSIPKPISSLLIRGWNACPEGRPEFSEVVMKLE 301 >6J5U-C nrPDB Length = 426 Score = 109 bits (273), Expect = 1e-24, Method: Composition-based stats. Identities = 40/240 (16%), Positives = 93/240 (38%), Gaps = 22/240 (9%) Query: 35 KEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPE 94 K ++ +G+GGFGC++ ++ + S + V +LK E Sbjct: 84 KNFRQDNLLGEGGFGCVFKGWIDQTSLTASRPGSGIVV-------AVKQLKPEGFQGHKE 136 Query: 95 QIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF--GSDLQKIYEANAKRFSRK 152 + + +L + + G R ++ + GS ++ A+ + Sbjct: 137 WLTEVNYLGQLSHPNLVLLVGY----CAEGENRLLVYEFMPKGSLENHLFRRGAQPLTWA 192 Query: 153 TVLQLSLRILDILEYIHEHE--YVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVH 210 +++++ L ++HE + ++ D KA+N+LL+ L D+GLA P G + Sbjct: 193 IRMKVAVGAAKGLTFLHEAKSQVIYRDFKAANILLDAD--FNAKLSDFGLAKA-GPTGDN 249 Query: 211 KEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKY 270 GT + + + + + D+ G +++ ++G +++ +Y Sbjct: 250 THVSTK----VIGTHGYAAPEYVATGRLTAKSDVYSFGVVLLELISGRRAMDNSNGGNEY 305 >4XUF-A nrPDB Length = 297 Score = 109 bits (273), Expect = 1e-24, Method: Composition-based stats. Identities = 42/298 (14%), Positives = 98/298 (32%), Gaps = 62/298 (20%) Query: 35 KEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKV-----EPSDNGPLFTELKFYQR 89 + + G +G G FG + A G VK+ + S+ L +ELK + Sbjct: 9 ENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQ 68 Query: 90 AAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFG-SDLQKIYEANAKR 148 + + G+ ++I + DL + ++ Sbjct: 69 LGS--------------HENIVNLLGA----CTLSGPIYLIFEYCCYGDLLNYLRSKREK 110 Query: 149 FSRKTV----------------------LQLSLRILDILEYIHEHEYVHGDIKASNLLLN 186 FS + L + ++ +E++ VH D+ A N+L+ Sbjct: 111 FSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVT 170 Query: 187 YKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEI 246 + V + D+GLA + + + +++ + ++ + + D+ Sbjct: 171 HGK--VVKICDFGLAR-----DIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWS 223 Query: 247 LGYCMIQWLT-GHLPWEDNLKDPKYVRDSKIRYR--------ENIASLMDKCFPEKNK 295 G + + + G P+ D + + + ++ E I +M C+ ++ Sbjct: 224 YGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSR 281 >5X02-A nrPDB Length = 347 Score = 109 bits (273), Expect = 1e-24, Method: Composition-based stats. Identities = 42/298 (14%), Positives = 98/298 (32%), Gaps = 62/298 (20%) Query: 35 KEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKV-----EPSDNGPLFTELKFYQR 89 + + G +G G FG + A G VK+ + S+ L +ELK + Sbjct: 48 ENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQ 107 Query: 90 AAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFG-SDLQKIYEANAKR 148 + + G+ ++I + DL + ++ Sbjct: 108 LGS--------------HENIVNLLGA----CTLSGPIYLIFEYCCYGDLLNYLRSKREK 149 Query: 149 FSRKTV----------------------LQLSLRILDILEYIHEHEYVHGDIKASNLLLN 186 FS + L + ++ +E++ VH D+ A N+L+ Sbjct: 150 FSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVT 209 Query: 187 YKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEI 246 + V + D+GLA + + + +++ + ++ + + D+ Sbjct: 210 HGK--VVKICDFGLAR-----DIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWS 262 Query: 247 LGYCMIQWLT-GHLPWEDNLKDPKYVRDSKIRYR--------ENIASLMDKCFPEKNK 295 G + + + G P+ D + + + ++ E I +M C+ ++ Sbjct: 263 YGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSR 320 >2BUJ-A nrPDB Length = 317 Score = 109 bits (273), Expect = 2e-24, Method: Composition-based stats. Identities = 42/244 (17%), Positives = 87/244 (35%), Gaps = 27/244 (11%) Query: 28 IITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFY 87 + + K + +G+GGF + L E + +K + + Sbjct: 22 HMVIIDNKHYLFIQKLGEGGFSYVDLV-----EGLHDGHFYALK-----------RILCH 65 Query: 88 QRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSD----LQKIYE 143 ++ + E ++ R + + + L ++ K ++++ F + + Sbjct: 66 EQQDREEAQREADMHRLFNHPNILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLK 125 Query: 144 ANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYR 203 + +L L L I LE IH Y H D+K +N+LL + L+D G + Sbjct: 126 DKGNFLTEDQILWLLLGICRGLEAIHAKGYAHRDLKPTNILLGDEGQPV--LMDLGSMNQ 183 Query: 204 YC--PEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAP---SRRGDLEILGYCMIQWLTGH 258 C EG + TI + + + + + R D+ LG + + G Sbjct: 184 ACIHVEGSRQALTLQDWAAQRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGE 243 Query: 259 LPWE 262 P++ Sbjct: 244 GPYD 247 >4XLV-A nrPDB Length = 328 Score = 109 bits (272), Expect = 2e-24, Method: Composition-based stats. Identities = 46/319 (14%), Positives = 115/319 (36%), Gaps = 44/319 (13%) Query: 20 AEQFAVGEIITD---MAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSD 76 ++ F + D +++++ + +GQG FG +Y + ++ VK ++ Sbjct: 21 SDVFPSSVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTV-NE 79 Query: 77 NGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFG- 135 + L ++F A+ ++ + ++ LGV + ++M+ Sbjct: 80 SASLRERIEFLNEASV---MKGFTCHHVVRLLGVV----------SKGQPTLVVMELMAH 126 Query: 136 SDLQKIY---------EANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLN 186 DL+ + + ++Q++ I D + Y++ ++VH D+ A N ++ Sbjct: 127 GDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMV- 185 Query: 187 YKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEI 246 + V + D+G+ + +Y + + + + ++ + D+ Sbjct: 186 -AHDFTVKIGDFGMTR----DIYETDYYRKGGKGLL-PVRWMAPESLKDGVFTTSSDMWS 239 Query: 247 LGYCMIQWLT-GHLPWEDNLKDPKYVRDSKIRYR-------ENIASLMDKCFPEKNKPGE 298 G + + + P++ + Y E + LM C+ P Sbjct: 240 FGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFN--PNM 297 Query: 299 IAKYMETVKLLDYTEKPLY 317 ++E V LL P + Sbjct: 298 RPTFLEIVNLLKDDLHPSF 316 >5X5O-A nrPDB Length = 310 Score = 109 bits (272), Expect = 2e-24, Method: Composition-based stats. Identities = 38/290 (13%), Positives = 90/290 (31%), Gaps = 55/290 (18%) Query: 44 GQGGFGCIYLAD-MNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRT 102 G G FG +Y A ++ + V ++ E Sbjct: 24 GGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAE-------------------------IL 58 Query: 103 RKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFG-SDLQKIYEAN-AKRFSRKTVLQLSLR 160 L + + +++G L ++ + L +N ++ ++ + Sbjct: 59 SVLSHRNIIQFYGVIL----EPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATD 114 Query: 161 ILDILEYIHEH---EYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDP 217 + + Y+H + +H D+K+ N+++ + + D+G + + Sbjct: 115 VAKGMHYLHMEAPVKVIHRDLKSRNVVIAADG--VLKICDFGASR---------FHNHTT 163 Query: 218 KRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIR 277 GT + + + + S D G + + LT +P++ + Sbjct: 164 HMSLVGTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKN 223 Query: 278 YRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDILLQG 327 R I S P A+ + D ++P ++ + IL Sbjct: 224 ERLTIPSSC---------PRSFAELLHQCWEADAKKRPSFKQIISILESM 264 >5XD6-A nrPDB Length = 305 Score = 109 bits (271), Expect = 3e-24, Method: Composition-based stats. Identities = 40/254 (15%), Positives = 88/254 (34%), Gaps = 42/254 (16%) Query: 19 LAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNG 78 ++ + + D+ + IG+G +G ++ + S ++ K++ S Sbjct: 7 ISVAAIPADELRDIT-DNYGSKSLIGEGSYGRVFYGILKSGKAAAIK-----KLDSSKQP 60 Query: 79 PLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSD 137 + +F + + ++++ V G + R + + Sbjct: 61 ----DQEFLAQVSMVSRLRQE---------NVVALLGYCV----DGPLRVLAYEYAPNGS 103 Query: 138 LQKIYE--------ANAKRFSRKTVLQLSLRILDILEYIHEH---EYVHGDIKASNLLLN 186 L I S +++++ LEY+HE +H DIK+SN+LL Sbjct: 104 LHDILHGRKGVKGAQPGPVLSWHQRVKIAVGAARGLEYLHEKANPHVIHRDIKSSNVLL- 162 Query: 187 YKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEI 246 + D + D+ L+ + GT + + + S + D+ Sbjct: 163 -FDDDVAKIADFDLSNQAPDMAARLHSTR-----VLGTFGYHAPEYAMTGTLSTKSDVYS 216 Query: 247 LGYCMIQWLTGHLP 260 G +++ LTG P Sbjct: 217 FGVVLLELLTGRKP 230 >3UIM-A nrPDB Length = 326 Score = 108 bits (270), Expect = 3e-24, Method: Composition-based stats. Identities = 58/326 (17%), Positives = 114/326 (34%), Gaps = 58/326 (17%) Query: 15 AKRHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEP 74 + HL + +A + +G+GGFG +Y + V +K E Sbjct: 10 PEVHLGQLKRFSLRELQVASDNFSNKNILGRGGFGKVYKGRLADGTLVAVKR---LKEER 66 Query: 75 SDNGPLFTELKFYQRAAKPEQIQKWIRTRKLK-YLGVPKYWGSGLHDKNGK-SYRFMIMD 132 + G L Q Q + + + + + G + Y +M Sbjct: 67 TQGGEL--------------QFQTEVEMISMAVHRNLLRLRGFCMTPTERLLVYPYMANG 112 Query: 133 RFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEH---EYVHGDIKASNLLLNYKN 189 S L++ E+ +++L L Y+H+H + +H D+KA+N+LL+ + Sbjct: 113 SVASCLRERPESQP-PLDWPKRQRIALGSARGLAYLHDHCDPKIIHRDVKAANILLDEE- 170 Query: 190 PDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGY 249 + + D+GLA + H GTI + + + S + D+ G Sbjct: 171 -FEAVVGDFGLAKLMDYKDTHVTTAVR------GTIGHIAPEYLSTGKSSEKTDVFGYGV 223 Query: 250 CMIQWLTGHLPWE-------------DNLKDPKYVRDS------------KIRYRENIAS 284 +++ +TG ++ D +K + K E + Sbjct: 224 MLLELITGQRAFDLARLANDDDVMLLDWVKGLLKEKKLEALVDVDLQGNYKDEEVEQLIQ 283 Query: 285 LMDKCFPEKNKPGEIAKYMETVKLLD 310 + C ++ P E K E V++L+ Sbjct: 284 VALLC--TQSSPMERPKMSEVVRMLE 307 >4TPT-A nrPDB Length = 303 Score = 108 bits (270), Expect = 3e-24, Method: Composition-based stats. Identities = 47/307 (15%), Positives = 93/307 (30%), Gaps = 43/307 (14%) Query: 40 GLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKW 99 G +G+G FG + V+K EL + + + Sbjct: 5 GEVLGKGFFGQAIKVTHK-----ATGKVMVMK-----------ELIRCDEETQKTFLTEV 48 Query: 100 IRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSL 159 R L + V K+ G DK ++ + K + + F + ++ + Sbjct: 49 KVMRSLDHPNVLKFIGVLYKDKK----LNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAK 104 Query: 160 RILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKR 219 I + Y+H +H D+ + N L+ K V + D+GL+ E ++ + Sbjct: 105 GIASGMAYLHSMCIIHRDLNSHNCLI--KLDKTVVVADFGLSRLIVEERKRAPMEKATTK 162 Query: 220 -------------CHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLK 266 G + + + NG + D+ G + + + D L Sbjct: 163 KRTLRKNDRKKRYTVVGNPYWMAPEMLNGKSYDETVDIFSFGIVLCEIIGQVYADPDCLP 222 Query: 267 DPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDILLQ 326 + N+ +K P P + L+ +P + L D Sbjct: 223 RTLD-------FGLNVKLFWEKFVPTDCPPAFFPLAAICCR-LEPESRPAFSKLEDSFEA 274 Query: 327 GLKAIGS 333 +G Sbjct: 275 LSLYLGE 281 >3G0E-A nrPDB Length = 336 Score = 108 bits (270), Expect = 4e-24, Method: Composition-based stats. Identities = 45/311 (14%), Positives = 102/311 (32%), Gaps = 31/311 (9%) Query: 18 HLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEP--- 74 ++ + + + G +G G FG + A + VK+ Sbjct: 29 YIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSA 88 Query: 75 --SDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPK----YWGSGLHDKNGKSYRF 128 ++ L +ELK I + + + +G L+ K F Sbjct: 89 HLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSF 148 Query: 129 MIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYK 188 + I E + + +L S ++ + ++ +H D+ A N+LL + Sbjct: 149 I----CSKTSPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHG 204 Query: 189 NPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILG 248 + D+GLA + K +++ + ++ + D+ G Sbjct: 205 RIT--KICDFGLARDIKNDSN-----YVVKGNARLPVKWMAPESIFNCVYTFESDVWSYG 257 Query: 249 YCMIQWLT-GHLPWEDNLKDPKYVRDSKIRYR--------ENIASLMDKCFPEKNKPGEI 299 + + + G P+ D K+ + K +R + +M C+ P + Sbjct: 258 IFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDAD--PLKR 315 Query: 300 AKYMETVKLLD 310 + + V+L++ Sbjct: 316 PTFKQIVQLIE 326 >5GRN-A nrPDB Length = 356 Score = 108 bits (270), Expect = 4e-24, Method: Composition-based stats. Identities = 44/288 (15%), Positives = 99/288 (34%), Gaps = 31/288 (10%) Query: 39 VGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKV-----EPSDNGPLFTELKFYQRAAK- 92 +G +G G FG + VK+ S+ L +ELK Sbjct: 50 LGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPH 109 Query: 93 ---PEQIQKWIRTRKLKYLGVPKYWG---SGLHDKNGKSYRFMIMDRFGSDLQKIY-EAN 145 + ++ + + ++G + LH S+++ + + N Sbjct: 110 LNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHKKKSMLDSEVKNLLSDDN 169 Query: 146 AKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYC 205 ++ + +L + ++ +E++ VH D+ A N+LL V + D+GLA Sbjct: 170 SEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGK--IVKICDFGLAR--- 224 Query: 206 PEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT-GHLPWEDN 264 + + K +++ + ++ + D+ G + + + G P+ Sbjct: 225 --DIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGM 282 Query: 265 LKDPKYVRDSKIRYR--------ENIASLMDKCFPEKNKPGEIAKYME 304 + D + K YR + +M KC+ + P + + Sbjct: 283 MVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSE--PEKRPSFYH 328 >4O2Z-A nrPDB Length = 377 Score = 108 bits (269), Expect = 5e-24, Method: Composition-based stats. Identities = 32/240 (13%), Positives = 81/240 (33%), Gaps = 26/240 (10%) Query: 36 EWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPE 94 ++ + +G G +G D ++ E KV +F +++ +R + Sbjct: 46 KYTLLKILGMGAYGIACSCLDGDTGE----------KVSIKKCRDVFRDVEDGKRVLREI 95 Query: 95 QIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTV 154 + ++ L L V + + +++ D+ + + + + Sbjct: 96 DMMRFFHHENL--LNVVNILPPLKREYHSFEDVYVVTPLMDVDMNVVL-RSRQVLEESHM 152 Query: 155 LQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYK 214 +IL L+Y+H H D+K +NL+ N ++ ++D+GL+ + Sbjct: 153 QYFVYQILRGLKYLHSANVAHRDLKPANLVTNIS--CELKIIDFGLSR-------SVDVP 203 Query: 215 EDPKRCHDGTIEFTSID-AHNGVAPSRRGDLEILGYCMIQWLTGHL--PWEDNLKDPKYV 271 + T + + S D+ +G + P + + + + Sbjct: 204 YSELTDYVITRWYRPPELLLENTNYSTAVDIWSVGCIFAEMYNRKPVFPGRNTMDQLRMI 263 >3ZBF-A nrPDB Length = 322 Score = 108 bits (268), Expect = 6e-24, Method: Composition-based stats. Identities = 53/322 (16%), Positives = 122/322 (37%), Gaps = 50/322 (15%) Query: 27 EIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKF 86 E + +++ + L +G G FG +Y V + +G + +K Sbjct: 25 ENLPAFPREKLTLRLLLGSGAFGEVYEG-------------TAVDILGVGSGEIKVAVKT 71 Query: 87 YQRAAKPEQIQKWIRTRKL----KYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIY 142 ++ + ++ ++++ L + + K G L ++ Y + + G L + Sbjct: 72 LKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEP--QYIILELMEGGDLLTYLR 129 Query: 143 EANAKRF-----SRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKN---PDQVY 194 +A F + ++ L + I Y+ ++H D+ A N L++ K+ P V Sbjct: 130 KARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVK 189 Query: 195 LVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQW 254 + D+GLA +++ E + + + ++ + + D+ G + + Sbjct: 190 IGDFGLARDIYKNDYYRKRGEGLL-----PVRWMAPESLMDGIFTTQSDVWSFGILIWEI 244 Query: 255 LT-GHLPW--EDNLKDPKYVRDS-----KIRYRENIASLMDKCFPEKNKPGEIAKYMETV 306 LT GH P+ NL YV+ +++ +LM +C+ ++ P + + Sbjct: 245 LTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQE--PDQRPTFHRIQ 302 Query: 307 KLLDYTEKPLYENLRDILLQGL 328 L + R+ L + Sbjct: 303 DQL--------QLFRNFFLNSI 316 >3DLS-A nrPDB Length = 335 Score = 108 bits (268), Expect = 6e-24, Method: Composition-based stats. Identities = 35/230 (15%), Positives = 79/230 (34%), Gaps = 24/230 (10%) Query: 34 KKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKP 93 +++ P+G G FG ++ A + VVK + ++ + Sbjct: 23 SQKYSTMSPLGSGAFGFVWTAVDKEK-----NKEVVVKFIKKEKVLEDCWIEDPKLGKVT 77 Query: 94 EQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKI-YEANAKRFSRK 152 +I R + V + + + ++M++ GS L + R Sbjct: 78 LEIAILSRVEHANIIKVLDIF-------ENQGFFQLVMEKHGSGLDLFAFIDRHPRLDEP 130 Query: 153 TVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKE 212 + +++ + Y+ + +H DIK N+++ + L+D+G A Sbjct: 131 LASYIFRQLVSAVGYLRLKDIIHRDIKDENIVIAEDFT--IKLIDFGSAAYLE------- 181 Query: 213 YKEDPKRCHDGTIEFTSIDAHNGVAP-SRRGDLEILGYCMIQWLTGHLPW 261 + GTIE+ + + G ++ LG + + P+ Sbjct: 182 -RGKLFYTFCGTIEYCAPEVLMGNPYRGPELEMWSLGVTLYTLVFEENPF 230 >3E3P-A nrPDB Length = 360 Score = 108 bits (268), Expect = 7e-24, Method: Composition-based stats. Identities = 38/246 (15%), Positives = 80/246 (32%), Gaps = 43/246 (17%) Query: 32 MAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAA 91 ++V GQG FG + L S+ +K D EL+ Q A Sbjct: 20 KEMDRFQVERMAGQGTFGTVQLGKEKST-----GMSVAIKKVIQDPRFRNRELQIMQDLA 74 Query: 92 KPEQIQKWIRTRKLKYLGVPKY--WGSGLHDKNGKS-YRFMIMDRFGSDLQKIYEANAKR 148 L + + + + L +++ + Y ++M+ + Sbjct: 75 V------------LHHPNIVQLQSYFYTLGERDRRDIYLNVVMEYV----PDTLHRCCRN 118 Query: 149 FSRKTVL-------QLSLRILDILEYIH--EHEYVHGDIKASNLLLNYKNPDQVYLVDYG 199 + R+ V +++ + +H H DIK N+L+N + + L D+G Sbjct: 119 YYRRQVAPPPILIKVFLFQLIRSIGCLHLPSVNVCHRDIKPHNVLVNEAD-GTLKLCDFG 177 Query: 200 LAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAP-SRRGDLEILGYCMIQWLTGH 258 A + P + Y + + + G + D+ +G + + G Sbjct: 178 SAKKLSPSEPNVAYICSRY--------YRAPELIFGNQHYTTAVDIWSVGCIFAEMMLGE 229 Query: 259 LPWEDN 264 + + Sbjct: 230 PIFRGD 235 >3LMG-A nrPDB Length = 344 Score = 108 bits (268), Expect = 7e-24, Method: Composition-based stats. Identities = 45/283 (15%), Positives = 93/283 (32%), Gaps = 35/283 (12%) Query: 21 EQFAVGEIITDMAKKEWK-----VGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPS 75 E E + + +K +G G FG ++ C+ +E Sbjct: 12 EPLDPSEKANKVLARIFKETELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDK 71 Query: 76 DNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFG 135 F + + A L + + + G +++ + Sbjct: 72 SGRQSFQAVTDHMLA-----------IGSLDHAHIVRLLGLCPGSSLQLVTQYLPL---- 116 Query: 136 SDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYL 195 L + + +L ++I + Y+ EH VH ++ A N+LL K+P QV + Sbjct: 117 GSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLL--KSPSQVQV 174 Query: 196 VDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWL 255 D+G+A P+ Y E I++ ++++ + + + D+ G + + + Sbjct: 175 ADFGVADLLPPDDKQLLYSEAKT-----PIKWMALESIHFGKYTHQSDVWSYGVTVWELM 229 Query: 256 T-GHLPWEDNLKDPKYVRDSKIRYRENI-------ASLMDKCF 290 T G P+ K +M KC+ Sbjct: 230 TFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCW 272 >3HNG-A nrPDB Length = 360 Score = 107 bits (267), Expect = 8e-24, Method: Composition-based stats. Identities = 54/359 (15%), Positives = 111/359 (30%), Gaps = 73/359 (20%) Query: 15 AKRHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKV-- 72 E+ + A++ K+G +G+G FG + A + + VK+ Sbjct: 7 PLDEQCERLPYDASKWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLK 66 Query: 73 ---EPSDNGPLFTELKFYQRAAKPEQIQKWIR------------TRKLKYLGVPKYWGSG 117 S+ L TELK + + KY + Y S Sbjct: 67 EGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSK 126 Query: 118 LHDKNGKSYRFMIMD----RFGSDLQ---------------------------------- 139 + M+ + L+ Sbjct: 127 RDLFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSGFQEDKSLSDVEEEE 186 Query: 140 KIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYG 199 + + + ++ S ++ +E++ + +H D+ A N+LL+ N V + D+G Sbjct: 187 DSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENN--VVKICDFG 244 Query: 200 LAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT-GH 258 LA ++K K +++ + ++ S + D+ G + + + G Sbjct: 245 LAR-----DIYKNPDYVRKGDTRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGG 299 Query: 259 LPWEDNLKDPKYVRDSKIRYR--------ENIASLMDKCFPEKNKPGEIAKYMETVKLL 309 P+ D + + R I +M C+ P E ++ E V+ L Sbjct: 300 SPYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWH--RDPKERPRFAELVEKL 356 >3KUL-B nrPDB Length = 325 Score = 107 bits (266), Expect = 9e-24, Method: Composition-based stats. Identities = 41/290 (14%), Positives = 95/290 (32%), Gaps = 35/290 (12%) Query: 31 DMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRA 90 ++ + IG G G + + D P +K Y Sbjct: 45 EIEASRIHIEKIIGSGDSGEVCYGRLRVPGQ--RDVPVAIK----------ALKAGYTER 92 Query: 91 AKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYEANAKRF 149 + + + + + + + + G ++ + L + +F Sbjct: 93 QRRDFLSEASIMGQFDHPNIIRLEGV----VTRGRLAMIVTEYMENGSLDTFLRTHDGQF 148 Query: 150 SRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGV 209 + ++ + + + Y+ + YVH D+ A N+L++ + D+GL+ + Sbjct: 149 TIMQLVGMLRGVGAGMRYLSDLGYVHRDLAARNVLVDSNLVC--KVSDFGLSRVLEDDPD 206 Query: 210 HKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWL-TGHLPWEDNLKDP 268 K I +T+ +A S D+ G M + L G P+ + + + Sbjct: 207 AAYTTTGGKI----PIRWTAPEAIAFRTFSSASDVWSFGVVMWEVLAYGERPYWN-MTNR 261 Query: 269 KYVRDSKIRYR--------ENIASLMDKCFPEKNKPGEIAKYMETVKLLD 310 + + YR + LM C+ + + ++ + V +LD Sbjct: 262 DVISSVEEGYRLPAPMGCPHALHQLMLDCWHKDR--AQRPRFSQIVSVLD 309 >6CTH-A nrPDB Length = 309 Score = 107 bits (266), Expect = 1e-23, Method: Composition-based stats. Identities = 41/243 (16%), Positives = 83/243 (34%), Gaps = 32/243 (13%) Query: 31 DMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRA 90 + +G+GGFG +Y + S++ V KV + Sbjct: 11 AKVTSNFNAENKLGEGGFGSVYRGFLRDSDTY----IAVKKVSRASKQ------------ 54 Query: 91 AKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFS 150 E + +L++ + K G + + ++ + + + K Sbjct: 55 GIKEYASEVKIISRLRHKNLVKLIGW----CHERGELMLVYEFMANGSLDSHIFKGKSLL 110 Query: 151 RKTVL-QLSLRILDILEYIHEHE---YVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCP 206 V ++ + L Y+HE +H DIK SN++L+ L D+GLA Sbjct: 111 TWEVRYRIVKDLASALLYLHEEGDHCVLHRDIKTSNIMLDSS--FNAKLGDFGLARLVD- 167 Query: 207 EGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLK 266 K K GT+ + + + + S+ D+ G ++ +G E + Sbjct: 168 -----HAKGLKKTLLAGTVGYMAPECLSSGKASKESDVYSFGVVALEIASGRRSIEPKFE 222 Query: 267 DPK 269 + + Sbjct: 223 ESE 225 >2VWV-A nrPDB Length = 302 Score = 107 bits (266), Expect = 1e-23, Method: Composition-based stats. Identities = 55/305 (18%), Positives = 96/305 (31%), Gaps = 41/305 (13%) Query: 20 AEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMN---SSESVGSDAPCVVKVEPSD 76 AV E ++ K+ IG G FG + + ES + Sbjct: 1 DPNEAVREFAKEIDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQ 60 Query: 77 NGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-- 134 +E + P I+ L S MI+ F Sbjct: 61 RREFLSEASIMGQFEHPNIIR--------------------LEGVVTNSMPVMILTEFME 100 Query: 135 GSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVY 194 L N +F+ ++ + I + Y+ E YVH D+ A N+L+N Sbjct: 101 NGALDSFLRLNDGQFTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVC--K 158 Query: 195 LVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQW 254 + D+GL+ E + E I +T+ +A + D G M + Sbjct: 159 VSDFGLSRFL--EENSSDPTETSSLGGKIPIRWTAPEAIAFRKFTSASDAWSYGIVMWEV 216 Query: 255 LT-GHLPWEDNLKDPKYVRDSKIRYRENIAS--------LMDKCFPEKNKPGEIAKYMET 305 ++ G P+ D + + + + YR LM C+ + ++ + Sbjct: 217 MSFGERPYWD-MSNQDVINAIEQDYRLPPPPDCPTSLHQLMLDCWQKDR--NARPRFPQV 273 Query: 306 VKLLD 310 V LD Sbjct: 274 VSALD 278 >3I81-A nrPDB Length = 315 Score = 107 bits (266), Expect = 1e-23, Method: Composition-based stats. Identities = 46/305 (15%), Positives = 106/305 (34%), Gaps = 41/305 (13%) Query: 31 DMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRA 90 ++A+++ + +GQG FG +Y A VVK EP + T + Sbjct: 14 EVAREKITMSRELGQGSFGMVYEG----------VAKGVVKDEPETRVAIKTVNEAASMR 63 Query: 91 AKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYEANAKRF 149 + E + + ++ V + G + +IM+ DL+ + Sbjct: 64 ERIEFLNEASVMKEFNCHHVVRLLGV----VSQGQPTLVIMELMTRGDLKSYLRSLRPEM 119 Query: 150 ---------SRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGL 200 S ++Q++ I D + Y++ +++VH D+ A N ++ V + D+G+ Sbjct: 120 ENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFT--VKIGDFGM 177 Query: 201 AYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT-GHL 259 + +Y + + + S ++ + D+ G + + T Sbjct: 178 TR----DIYETDYYRKGGKGLL-PVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQ 232 Query: 260 PWEDNLKDPKYVRDSKIRYRENI-------ASLMDKCFPEKNKPGEIAKYMETVKLLDYT 312 P++ + + + LM C+ P ++E + + Sbjct: 233 PYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYN--PKMRPSFLEIISSIKEE 290 Query: 313 EKPLY 317 +P + Sbjct: 291 MEPGF 295 >5TE0-A nrPDB Length = 347 Score = 106 bits (265), Expect = 1e-23, Method: Composition-based stats. Identities = 44/317 (13%), Positives = 103/317 (32%), Gaps = 51/317 (16%) Query: 11 RQSSAKRHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVV 70 ++ F +G ++ V + +GGF ++L ++ V Sbjct: 2 TSGLGSGYIGRVFGIGR-------QQVTVDEVLAEGGFAIVFLVRTSNGMKCALKRMFVN 54 Query: 71 KVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKS--YRF 128 D E++ + + + + Y S +++ + Sbjct: 55 --NEHDLQVCKREIQIMRDLS--------------GHKNIVGYIDSSINNVSSGDVWEVL 98 Query: 129 MIMDRF-GSDLQKIYEANAKR-FSRKTVLQLSLRILDILEYIHEHE--YVHGDIKASNLL 184 ++MD G + + + F+ VLQ+ + + +H+ + +H D+K N+L Sbjct: 99 ILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENIL 158 Query: 185 LNYKNPDQVYLVDYGLA--YRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHN---GVAPS 239 L+ + L D+G A P+ ED + + T+ + + + N G + Sbjct: 159 LHDRG--HYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYT-TLSYRAPEMVNLYSGKIIT 215 Query: 240 RRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEI 299 + D+ LG + + LP+ V + ++ Sbjct: 216 TKADIWALGCLLYKLCYFTLPF-----GESQVAICDGNFTIP---------DNSRYSQDM 261 Query: 300 AKYMETVKLLDYTEKPL 316 + + D ++P Sbjct: 262 HCLIRYMLEPDPDKRPD 278 >5IKW-A nrPDB Length = 310 Score = 106 bits (264), Expect = 2e-23, Method: Composition-based stats. Identities = 46/291 (15%), Positives = 105/291 (36%), Gaps = 34/291 (11%) Query: 25 VGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTEL 84 VG + + + + + + +GGF ++L + V + D E+ Sbjct: 4 VGVRVFAVGRHQVTLEESLAEGGFSTVFLVRTHGGIRCALKRMYVNNM--PDLNVCKREI 61 Query: 85 KFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMI-MDRF--GSDLQKI 141 + + + + Y ++ + + +I M+ G + ++ Sbjct: 62 TIMKELS--------------GHKNIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQM 107 Query: 142 YEANAKRFSRKTVLQLSLRILDILEYIHEHE--YVHGDIKASNLLLNYKNPDQVYLVDYG 199 + F+ VLQ+ + + +H+ + +H D+K N+LLN + L D+G Sbjct: 108 NKKLQTGFTEPEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLN--DGGNYVLCDFG 165 Query: 200 LA--YRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHN---GVAPSRRGDLEILGYCMIQW 254 A P+ E+ + + T+ + + + N G + + D+ LG + + Sbjct: 166 SATNKFLNPQKDGVNVVEEEIKKYT-TLSYRAPEMINLYGGKPITTKADIWALGCLLYKL 224 Query: 255 LTGHLPW---EDNLKDPKYVRDSKIRYRENIASLM--DKCFPEKNKPGEIA 300 LP+ + + D + RY NI L+ +++P Sbjct: 225 CFFTLPFGESQVAICDGNFTIPDNSRYSRNIHCLIRFMLEPDPEHRPDIFQ 275 >4OTD-A nrPDB Length = 341 Score = 106 bits (264), Expect = 2e-23, Method: Composition-based stats. Identities = 46/251 (18%), Positives = 88/251 (35%), Gaps = 30/251 (11%) Query: 32 MAKKEWKVGLPIGQGGFGCIYLADMN-SSESVGSDAPCVVKVEPSDN-GPLFTELKFYQR 89 + +++K +G+G FG + L++ S E A + D L E + Sbjct: 9 LTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAA 68 Query: 90 AAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDR-FGSDLQKIYEANAKR 148 + + +G + +M+ G DL + ++ Sbjct: 69 VTSA------------GHPFLVNLFGC----FQTPEHVCFVMEYSAGGDL--MLHIHSDV 110 Query: 149 FSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEG 208 FS + S ++ L+++HEH+ V+ D+K L V + D+GL G Sbjct: 111 FSEPRAIFYSACVVLGLQFLHEHKIVYRDLKLD--NLLLDTEGYVKIADFGLCKEGMGYG 168 Query: 209 VHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDP 268 D GT EF + + + +R D LG + + L G P+ + ++ Sbjct: 169 -------DRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEE 221 Query: 269 KYVRDSKIRYR 279 + R Sbjct: 222 VFDSIVNDEVR 232 >5X8I-B nrPDB Length = 346 Score = 106 bits (263), Expect = 2e-23, Method: Composition-based stats. Identities = 33/264 (12%), Positives = 87/264 (32%), Gaps = 42/264 (15%) Query: 31 DMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRA 90 D+ +++ +G+G FG + + VK+ + + ++ + A Sbjct: 9 DVLSARYEIVDTLGEGAFGKVVECI----DHKAGGRHVAVKIVKNVD-------RYCEAA 57 Query: 91 AKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANA-KRF 149 Q+ + + T L + ++ + G + N F Sbjct: 58 RSEIQVLEHLNTTD---PNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPF 114 Query: 150 SRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQ----------------- 192 + +++ +I + ++H ++ H D+K N+L + + Sbjct: 115 RLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPD 174 Query: 193 VYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMI 252 + +VD+G A Y ++ T + + + + S+ D+ +G +I Sbjct: 175 IKVVDFGSA----------TYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILI 224 Query: 253 QWLTGHLPWEDNLKDPKYVRDSKI 276 ++ G + + +I Sbjct: 225 EYYLGFTVFPTHDSKEHLAMMERI 248 >4F9B-A nrPDB Length = 361 Score = 106 bits (263), Expect = 2e-23, Method: Composition-based stats. Identities = 50/270 (18%), Positives = 89/270 (32%), Gaps = 49/270 (18%) Query: 37 WKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQI 96 +K+ IG+G F +YLA ++V P + L K + P +I Sbjct: 23 FKIEDKIGEGTFSSVYLA------------TAQLQVGPEEKIAL----KHLIPTSHPIRI 66 Query: 97 QKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGS-DLQKIYEANAKRFSRKTVL 155 ++ + G G + + + M I + S + V Sbjct: 67 AAELQCLTVAG-GQDNVMGVKYCFRKND-HVVIAMPYLEHESFLDILNS----LSFQEVR 120 Query: 156 QLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVH----K 211 + L + L+ IH+ VH D+K SN L N + + LVD+GLA + Sbjct: 121 EYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRRLK-KYALVDFGLAQGTHDTKIELLKFV 179 Query: 212 EYKEDPKRCHD-----------------GTIEFTSIDAHNGVA-PSRRGDLEILGYCMIQ 253 + + +RC GT F + + + D+ G + Sbjct: 180 QSEAQQERCSQNKCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLS 239 Query: 254 WLTGHLPW---EDNLKDPKYVRDSKIRYRE 280 L+G P+ D+L + + Sbjct: 240 LLSGRYPFYKASDDLTALAQIMTIRGSRET 269 >5VD3-A nrPDB Length = 311 Score = 106 bits (263), Expect = 2e-23, Method: Composition-based stats. Identities = 35/218 (16%), Positives = 71/218 (32%), Gaps = 30/218 (13%) Query: 37 WKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKP-EQ 95 ++ +G G +G ++ KV ++G L+ + P ++ Sbjct: 59 FQRLSRLGHGSYGEVF------------------KVRSKEDGRLYAVKRSMSPFRGPKDR 100 Query: 96 IQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVL 155 +K + +G ++ + G LQ+ EA V Sbjct: 101 ARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVW 160 Query: 156 QLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKE 215 L L ++H VH D+K +N+ L + L D+GL G + Sbjct: 161 GYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRC--KLGDFGLLVELGTAGAGE---- 214 Query: 216 DPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQ 253 +G + + + G + D+ LG +++ Sbjct: 215 ----VQEGDPRYMAPELLQG-SYGTAADVFSLGLTILE 247 >2WO6-A nrPDB Length = 382 Score = 105 bits (262), Expect = 3e-23, Method: Composition-based stats. Identities = 37/235 (15%), Positives = 81/235 (34%), Gaps = 32/235 (13%) Query: 34 KKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAK 92 +++ IG+G FG + A D E V K F +A Sbjct: 53 MDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKK-------------AFLNQAQI 99 Query: 93 PEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSY-RFMIMDRFGSDLQKIY-EANAKRFS 150 ++ + + K+ KY+ L ++ + +L + N + S Sbjct: 100 EVRLLELMN----KHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVS 155 Query: 151 RKTVLQLSLRILDILEYIH--EHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEG 208 + + ++ L ++ E +H D+K N+LL + +VD+G + + Sbjct: 156 LNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFG-SSCQLGQR 214 Query: 209 VHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWED 263 +++ + + S + G+ D+ LG +++ TG + Sbjct: 215 IYQYIQSRF---------YRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSG 260 >3QD2-B nrPDB Length = 332 Score = 105 bits (262), Expect = 3e-23, Method: Composition-based stats. Identities = 42/304 (13%), Positives = 96/304 (31%), Gaps = 63/304 (20%) Query: 43 IGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQ----- 97 +G+GGFG ++ A + + + + E+K + P ++ Sbjct: 14 MGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAW 73 Query: 98 --------------KWIRTRKLKYL------------GVPKYWGSGLHDKNG-------K 124 W++ + + + + G K Sbjct: 74 LETPPEKWQEEMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFSTKNTVGQLQPSSPK 133 Query: 125 SYRFMIMDRFGSDLQKIYEANAKRFSRKTV-----LQLSLRILDILEYIHEHEYVHGDIK 179 Y ++ M + + + +R S + L + ++I + +E++H +H D+K Sbjct: 134 VYLYIQMQLCRK--ENLKDWMNRRCSLEDREHGVCLHIFIQIAEAVEFLHSKGLMHRDLK 191 Query: 180 ASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYK-----EDPKRCHDGTIEFTSIDAHN 234 SN+ + V + D+GL + + GT + S + + Sbjct: 192 PSNIFFTMDD--VVKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQVGTKLYMSPEQIH 249 Query: 235 GVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKN 294 G S + D+ LG + + L + ++R ++ +L + Sbjct: 250 GNNYSHKVDIFSLGLILFELLYSFS-----------TQMERVRIITDVRNLKFPLLFTQK 298 Query: 295 KPGE 298 P E Sbjct: 299 YPQE 302 >2RIO-A nrPDB Length = 434 Score = 105 bits (261), Expect = 4e-23, Method: Composition-based stats. Identities = 37/266 (13%), Positives = 86/266 (32%), Gaps = 38/266 (14%) Query: 58 SSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSG 117 S + +G + V + S G + ++ + T + V +Y+ Sbjct: 19 SEKILGYGSSGTVVFQGSFQGRPVAVKRMLIDFCDIALMEIKLLTESDDHPNVIRYY--- 75 Query: 118 LHDKNGKSYRFMIMDRFGSDLQKIYEA------NAKRFSRKTVLQLSLRILDILEYIHEH 171 + + ++ ++ +LQ + E+ N K + L +I + ++H Sbjct: 76 -CSETTDRFLYIALELCNLNLQDLVESKNVSDENLKLQKEYNPISLLRQIASGVAHLHSL 134 Query: 172 EYVHGDIKASNLLLNYK-----------NPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRC 220 + +H D+K N+L++ ++ + D+GL + + Sbjct: 135 KIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKL---DSGQSSFRTNLNN 191 Query: 221 HDGTIEFTSIDAHN-------GVAPSRRGDLEILGYCMIQWLT-GHLPWEDNLKDPKYVR 272 GT + + + +R D+ +G L+ G P+ D + Sbjct: 192 PSGTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPFGDKYSRESNII 251 Query: 273 DSKIRYRENIASLMDKCFPEKNKPGE 298 E KC +++ E Sbjct: 252 RGIFSLDE------MKCLHDRSLIAE 271 >2H34-A nrPDB Length = 309 Score = 104 bits (260), Expect = 5e-23, Method: Composition-based stats. Identities = 43/228 (18%), Positives = 82/228 (35%), Gaps = 25/228 (10%) Query: 37 WKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQI 96 +++ +G+GG G +Y A E + +K+ QR A+ Sbjct: 36 YRLRRLVGRGGMGDVYEA-----EDTVRERIVALKLMSETLSSDPVFRTRMQREART--- 87 Query: 97 QKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQ 156 +L+ V G D +I G DL + + + Sbjct: 88 -----AGRLQEPHVVPIHDFGEIDGQLYVDMRLI---NGVDLAAMLRRQG-PLAPPRAVA 138 Query: 157 LSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKED 216 + +I L+ H H D+K N+L++ + YLVD+G+A E + Sbjct: 139 IVRQIGSALDAAHAAGATHRDVKPENILVSADDF--AYLVDFGIASATTDEKL------T 190 Query: 217 PKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDN 264 GT+ + + + + + R D+ L + + LTG P++ + Sbjct: 191 QLGNTVGTLYYMAPERFSESHATYRADIYALTCVLYECLTGSPPYQGD 238 >4CRS-A nrPDB Length = 341 Score = 104 bits (260), Expect = 6e-23, Method: Composition-based stats. Identities = 59/336 (17%), Positives = 119/336 (35%), Gaps = 56/336 (16%) Query: 34 KKEWKVGLPIGQGGFGCIYLADM-NSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAK 92 ++++ + +G FG + LA+ N++E A + D K Sbjct: 11 LQDFRCCAVLLRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEK------- 63 Query: 93 PEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYEANAKRFSR 151 + + +++ + + K + +M+ G DL + + FS Sbjct: 64 ----RIFETVNSVRHPFLVNLFAC----FQTKEHVCFVMEYAAGGDL--MMHIHTDVFSE 113 Query: 152 KTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHK 211 + + ++ L+Y+HEH+ V+ D+K NLLL+ + V + D+GL G Sbjct: 114 PRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGF--VKIADFGLCKEGMGYG--- 168 Query: 212 EYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYV 271 D GT EF + + + +R D LG + + L G P+ + ++ + Sbjct: 169 ----DRTSTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFD 224 Query: 272 RDSKIRYR------ENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDILL 325 R S+M + + P + L +EK + + Sbjct: 225 SIVNDEVRYPRFLSTEAISIMRR--LLRRNPE---------RRLGASEKDAEDVKKHPFF 273 Query: 326 QGLKAIGSKDDGKLDLSVVENGGLKAKTITKKRKKE 361 + + D S + + +K I R +E Sbjct: 274 RLI-----------DWSALMDKKVKPPFIPTIRGRE 298 >5WNL-A nrPDB Length = 342 Score = 104 bits (259), Expect = 6e-23, Method: Composition-based stats. Identities = 47/301 (15%), Positives = 96/301 (31%), Gaps = 50/301 (16%) Query: 36 EWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQ 95 E+ +G GGFG +Y V +K PS + ++ + A K Sbjct: 21 EFAGWEKVGSGGFGQVYKV-----RHVHWKTWLAIKCSPSLHVDDRERMELLEEAKK--- 72 Query: 96 IQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFG-SDLQKIYEANAKRFSRKTV 154 + K +Y + +G + ++M+ L+K+ + + + Sbjct: 73 ----MEMAKFRY--ILPVYG------ICQEPVGLVMEYMETGSLEKLLASEPLPWDLR-- 118 Query: 155 LQLSLRILDILEYIHEHE--YVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKE 212 ++ + ++H +H ++K +N+LL+ V + D+GLA H Sbjct: 119 FRIVHETAVGMNFLHCMSPPLLHLNLKPANILLDAH--YHVKISDFGLAKCNGMSHSHDL 176 Query: 213 YKEDPKRCHDGTIEFTSIDAHNGVA--PSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKY 270 + GTI + + + + D+ + LT P+ D Sbjct: 177 SMD----GLFGTIAYLPPERIREKSRLFDTKHDVYSFAIVIWGVLTQKKPFADEKNILHI 232 Query: 271 VRDSKIRYRENIASLMD--------------KCFPEKNKPGEIAKYMETVKLL-DYTEKP 315 + +R + + +C+ P + E D EKP Sbjct: 233 MMKVVKGHRPELPPICRPRPRACASLIGLMQRCWHAD--PQVRPTFQEITSETEDLCEKP 290 Query: 316 L 316 Sbjct: 291 D 291 >6HV0-A nrPDB Length = 416 Score = 104 bits (259), Expect = 6e-23, Method: Composition-based stats. Identities = 35/236 (14%), Positives = 83/236 (35%), Gaps = 34/236 (14%) Query: 43 IGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRT 102 +G G G I M + V V ++ P E++ + + Sbjct: 16 LGHGAEGTIVYRGMFDNRDVA-----VKRILPECFSFADREVQLLRESD----------- 59 Query: 103 RKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRIL 162 ++ V +Y + + ++++ ++ + LQ+ E + L + Sbjct: 60 ---EHPNVIRY----FCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITLLQQTT 112 Query: 163 DILEYIHEHEYVHGDIKASNLLLNYKNPD-QVY--LVDYGLAYRYCPEGVHKEYKEDPKR 219 L ++H VH D+K N+L++ N ++ + D+GL + + + Sbjct: 113 SGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGR----HSFSRRS 168 Query: 220 CHDGTIEFTSIDAHNGVA---PSRRGDLEILGYCMIQWLT-GHLPWEDNLKDPKYV 271 GT + + + + P+ D+ G ++ G P+ +L+ + Sbjct: 169 GVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANI 224 >6FYV-A nrPDB Length = 337 Score = 104 bits (259), Expect = 7e-23, Method: Composition-based stats. Identities = 33/264 (12%), Positives = 90/264 (34%), Gaps = 42/264 (15%) Query: 31 DMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRA 90 D+ + +++ +G+G FG + ++ A +VK +E++ + Sbjct: 10 DVLRARYEIVDTLGEGAFGKVVEC-IDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHL 68 Query: 91 AKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANA-KRF 149 + + + L++ + ++ + G + N+ F Sbjct: 69 NSTDPNSVFRCVQMLEWFDHHGH-------------VCIVFELLGLSTYDFIKENSFLPF 115 Query: 150 SRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKN-----------------PDQ 192 + Q++ +I + ++H ++ H D+K N+L + Sbjct: 116 QIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTD 175 Query: 193 VYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMI 252 + +VD+G A Y ++ T + + + + S+ D+ +G +I Sbjct: 176 IKVVDFGSA----------TYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILI 225 Query: 253 QWLTGHLPWEDNLKDPKYVRDSKI 276 ++ G ++ + +I Sbjct: 226 EYYLGFTVFQTHDSKEHLAMMERI 249 >1LUF-A nrPDB Length = 343 Score = 104 bits (259), Expect = 7e-23, Method: Composition-based stats. Identities = 46/287 (16%), Positives = 89/287 (31%), Gaps = 27/287 (9%) Query: 41 LPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNG-----PLFTELKFYQRAAKPEQ 95 IG+G FG ++ A VK+ + E P Sbjct: 53 RDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNI 112 Query: 96 IQKWIRTRKLK--YLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQ---KIYEANAKRFS 150 ++ K L L++ + SDL ++ S Sbjct: 113 VKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRARVSSPGPPPLS 172 Query: 151 RKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVH 210 L ++ ++ + Y+ E ++VH D+ N L+ V + D+GL+ + Sbjct: 173 CAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGEN--MVVKIADFGLSRNIYSADYY 230 Query: 211 KEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQ-WLTGHLPWEDNLKDPK 269 K D I + ++ + D+ G + + + G P+ + Sbjct: 231 KADGNDAI-----PIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEV 285 Query: 270 --YVRDSKI-----RYRENIASLMDKCFPEKNKPGEIAKYMETVKLL 309 YVRD I + +LM C+ P + + ++L Sbjct: 286 IYYVRDGNILACPENCPLELYNLMRLCW--SKLPADRPSFCSIHRIL 330 >4PL5-B nrPDB Length = 435 Score = 103 bits (257), Expect = 1e-22, Method: Composition-based stats. Identities = 36/236 (15%), Positives = 83/236 (35%), Gaps = 34/236 (14%) Query: 43 IGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRT 102 +G G G I M + V V ++ P E++ + + Sbjct: 35 LGHGAEGTIVYKGMFDNRDVA-----VKRILPECFSFADREVQLLRESD----------- 78 Query: 103 RKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRIL 162 ++ V +Y + + ++++ ++ + LQ+ E + L + Sbjct: 79 ---EHPNVIRY----FCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITLLHQTT 131 Query: 163 DILEYIHEHEYVHGDIKASNLLLNYKNPD---QVYLVDYGLAYRYCPEGVHKEYKEDPKR 219 L ++H VH D+K N+LL+ N + + D+GL + + + Sbjct: 132 SGLAHLHSLNIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGR----HSFSRRS 187 Query: 220 CHDGTIEFTSIDAHNGVA---PSRRGDLEILGYCMIQWLT-GHLPWEDNLKDPKYV 271 GT + + + + P+ D+ G ++ G+ P+ +L+ + Sbjct: 188 GVPGTEGWIAPEMLSEDCKDNPTYTVDIFSAGCVFYYVISEGYHPFGKSLQRQANI 243 >2PMN-X nrPDB Length = 348 Score = 103 bits (257), Expect = 1e-22, Method: Composition-based stats. Identities = 53/346 (15%), Positives = 118/346 (34%), Gaps = 41/346 (11%) Query: 31 DMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRA 90 D ++++ + QG F I L + ++ +E + K ++ Sbjct: 27 DKYINDYRIIRTLNQGKFNKIILCE-KDNKFYALKKYEKSLLEKKRDFTKSNNDKISIKS 85 Query: 91 ---AKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMI---MDRFGSDLQKIYEA 144 ++Q + L + D+ Y +M + +F + + Sbjct: 86 KYDDFKNELQIITDIKNEYCLTCEGIITNY--DEVYIIYEYMENDSILKFDEYFFVLDKN 143 Query: 145 NAKRFSRKTVLQLSLRILDILEYIH-EHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYR 203 + + + +L+ YIH E H D+K SN+L++ +V L D+G + Sbjct: 144 YTCFIPIQVIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMDKNG--RVKLSDFGESEY 201 Query: 204 YCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAP--SRRGDLEILGYCMIQWLTGHLPW 261 + + + GT EF + + + + D+ LG C+ +P+ Sbjct: 202 MVDKKI---------KGSRGTYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMFYNVVPF 252 Query: 262 EDNLKDPK---YVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYE 318 + + +R I Y + + +K+ ++ + Sbjct: 253 SLKISLVELFNNIRTKNIEYPLDRNHFLYPLTNKKSTCSN-----------NFLSNEDID 301 Query: 319 NLRDILLQGLKAIGSKDDG-KLDL---SVVENGGLKAKTITKKRKK 360 L+ L + + +D K + + +E+ +K + KKRKK Sbjct: 302 FLKLFLRKNPAERITSEDALKHEWLADTNIEDLREFSKELYKKRKK 347 >6FEX-A nrPDB Length = 321 Score = 103 bits (256), Expect = 2e-22, Method: Composition-based stats. Identities = 49/319 (15%), Positives = 109/319 (34%), Gaps = 32/319 (10%) Query: 26 GEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSD--APCVVKVEPSDNGPLFTE 83 G D + + +G+G FG ++L +++S + + S V K P Sbjct: 7 GPPRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILR 66 Query: 84 LKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIY 142 + A + +++ +LK + + G + D MI D DL + Sbjct: 67 PDATKNARN-DFLKEVKIMSRLKDPNIIRLLGVCVQDDP----LCMITDYMENGDLNQFL 121 Query: 143 EAN------------AKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNP 190 A+ S +L ++ +I + Y+ +VH D+ N L+ Sbjct: 122 SAHQLEDKAAEGAPGDPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFT 181 Query: 191 DQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYC 250 + + D+G++ Y+ + I + + + + D+ G Sbjct: 182 --IKIADFGMSRNLYAGD---YYRVQGRAVL--PIRWMAWECILMGKFTTASDVWAFGVT 234 Query: 251 MIQ--WLTGHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKL 308 + + L P+ L D + + ++ +R+ + P P + + M Sbjct: 235 LWEVLMLCRAQPF-GQLTDEQVIENAGEFFRDQGRQVYLSRPPA--CPQGLYELMLRCWS 291 Query: 309 LDYTEKPLYENLRDILLQG 327 + ++P + L L + Sbjct: 292 RESEQRPPFSQLHRFLAED 310 >4CRL-A nrPDB Length = 406 Score = 101 bits (252), Expect = 5e-22, Method: Composition-based stats. Identities = 52/298 (17%), Positives = 104/298 (34%), Gaps = 37/298 (12%) Query: 40 GLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKW 99 G +G+G +G +Y A + + + ++ Sbjct: 27 GCKVGRGTYGHVYKAKRKD----------------GKDDKDYALKQIEGTGISMSACREI 70 Query: 100 IRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEAN--------AKRFSR 151 R+LK+ V + + +++ D DL I + + + R Sbjct: 71 ALLRELKHPNVISL--QKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPR 128 Query: 152 KTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNP--DQVYLVDYGLAYRYCPEGV 209 V L +ILD + Y+H + +H D+K +N+L+ + P +V + D G A + + Sbjct: 129 GMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSP-L 187 Query: 210 HKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRG-DLEILGYCMIQWLTGHLPWEDNLKDP 268 DP T + + + G + D+ +G + LT + +D Sbjct: 188 KPLADLDPVVV---TFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDI 244 Query: 269 KYVRDSKIRYRENIASLM----DKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRD 322 K + I ++M DK + + K E + M+ + YT L + + Sbjct: 245 KTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEK 302 >6BSD-A nrPDB Length = 876 Score = 101 bits (251), Expect = 5e-22, Method: Composition-based stats. Identities = 50/347 (14%), Positives = 113/347 (32%), Gaps = 38/347 (10%) Query: 4 VKAAQAGRQSSAKRHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVG 63 ++ G + G D + + +G+G FG ++L +++S + + Sbjct: 540 LQGVTGGNTYAVPALPPGAVGDGPPRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLV 599 Query: 64 SD--APCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDK 121 S V K P + A + +++ +LK + + G + D Sbjct: 600 SLDFPLNVRKGHPLLVAVKILRPDATKNARN-DFLKEVKIMSRLKDPNIIRLLGVCVQDD 658 Query: 122 NGKSYRFMIMDRF-GSDLQKIYEAN------------------AKRFSRKTVLQLSLRIL 162 MI D DL + A+ S +L ++ +I Sbjct: 659 P----LCMITDYMENGDLNQFLSAHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIA 714 Query: 163 DILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHD 222 + Y+ +VH D+ N L+ + + D+G++ Y+ + Sbjct: 715 SGMRYLATLNFVHRDLATRNCLVGENFT--IKIADFGMSRNLYAGD---YYRVQGRAVL- 768 Query: 223 GTIEFTSIDAHNGVAPSRRGDLEILGYCMIQ--WLTGHLPWEDNLKDPKYVRDSKIRYRE 280 I + + + + D+ G + + L P+ L D + + ++ +R+ Sbjct: 769 -PIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPF-GQLTDEQVIENAGEFFRD 826 Query: 281 NIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDILLQG 327 + P P + + M + ++P + L L + Sbjct: 827 QGRQVYLSRPPA--CPQGLYELMLRCWSRESEQRPPFSQLHRFLAED 871 >2QKW-B nrPDB Length = 321 Score = 101 bits (251), Expect = 6e-22, Method: Composition-based stats. Identities = 41/289 (14%), Positives = 88/289 (30%), Gaps = 34/289 (11%) Query: 35 KEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPE 94 + IG G FG +Y + V TE++ P Sbjct: 39 NNFDHKFLIGHGVFGKVYKGVLRDGAKVALKRRTPE--SSQGIEEFETEIETLSFCRHPH 96 Query: 95 QIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSR--K 152 + G D+ + G+ + +Y ++ S + Sbjct: 97 LVSLI-----------------GFCDERNEMILIYKYMENGNLKRHLYGSDLPTMSMSWE 139 Query: 153 TVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKE 212 L++ + L Y+H +H D+K+ N+LL+ + D+G++ + Sbjct: 140 QRLEICIGAARGLHYLHTRAIIHRDVKSINILLDENFVP--KITDFGISKKGTELDQ--- 194 Query: 213 YKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVR 272 GT+ + + + + D+ G + + L +L Sbjct: 195 --THLSTVVKGTLGYIDPEYFIKGRLTEKSDVYSFGVVLFEVLCARSAIVQSLPREMVNL 252 Query: 273 DSKIRYREN---IASLMDKCFPEKNKPGEIAKYMET---VKLLDYTEKP 315 N + ++D +K +P + K+ +T L ++P Sbjct: 253 AEWAVESHNNGQLEQIVDPNLADKIRPESLRKFGDTAVKCLALSSEDRP 301 >3RAW-A nrPDB Length = 381 Score = 101 bits (250), Expect = 7e-22, Method: Composition-based stats. Identities = 36/290 (12%), Positives = 103/290 (35%), Gaps = 42/290 (14%) Query: 5 KAAQAGRQSSAKRHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGS 64 ++ Q+ ++SS ++ + I D ++ +++ +G+G FG + ++ + Sbjct: 21 QSMQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVEC-LDHARGKSQ 79 Query: 65 DAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGK 124 A +++ E+ ++ I++ + K + + ++ H Sbjct: 80 VALKIIRNVGKYREAARLEINVLKK------IKEKDKENKFLCVLMSDWFNFHGH----- 128 Query: 125 SYRFMIMDRFGSD-LQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNL 183 + + G + + + E N + + V ++ ++ L ++HE++ H D+K N+ Sbjct: 129 --MCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENI 186 Query: 184 LLNYKN-----------------PDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIE 226 L + + D+G A + + T Sbjct: 187 LFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSA----------TFDHEHHTTIVATRH 236 Query: 227 FTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKI 276 + + + ++ D+ +G + ++ G ++ + V KI Sbjct: 237 YRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKI 286 >2X7G-A nrPDB Length = 389 Score = 100 bits (249), Expect = 9e-22, Method: Composition-based stats. Identities = 57/297 (19%), Positives = 99/297 (33%), Gaps = 71/297 (23%) Query: 28 IITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFY 87 I D+ + V +G G F ++L + A VVK E+K Sbjct: 24 KIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRF--VAMKVVKSAQHYTETALDEIKLL 81 Query: 88 Q--RAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQK-IYEA 144 + R + P K + + + + G + M+ + G L K I ++ Sbjct: 82 KCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVC---------MVFEVLGHHLLKWIIKS 132 Query: 145 NAKRFSRKTVLQLSLRILDILEYIHEH-EYVHGDIKASNLL------------------- 184 N + + V + ++L L+Y+H + +H DIK N+L Sbjct: 133 NYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQ 192 Query: 185 ------------------------LNYKNPDQV--YLVDYGLAYRYCPEGVHKEYKEDPK 218 L+ +N D++ + D G A VHK + ED + Sbjct: 193 KAGAPPPSGSAVSTAPAADLLVNPLDPRNADKIRVKIADLGNA-----CWVHKHFTEDIQ 247 Query: 219 RCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSK 275 T ++ SI+ G S D+ + TG +E + Y RD Sbjct: 248 -----TRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLFEPH-SGEDYSRDED 298 >3LLT-A nrPDB Length = 360 Score = 100 bits (248), Expect = 1e-21, Method: Composition-based stats. Identities = 45/252 (17%), Positives = 84/252 (33%), Gaps = 50/252 (19%) Query: 37 WKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQI 96 + V +G G FG + L + + VKV + K+ + A I Sbjct: 37 FLVIRKMGDGTFGRVLLCQ-----HIDNKKYYAVKVVRNIK-------KYTRSAKIEADI 84 Query: 97 QKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANA-KRFSRKTVL 155 K I+ + + KY G ++ + +I + G L +I N F + + Sbjct: 85 LKKIQNDDINNNNIVKYHGKFMYYDH----MCLIFEPLGPSLYEIITRNNYNGFHIEDIK 140 Query: 156 QLSLRILDILEYIHEHEYVHGDIKASNLLLN-----------------------YKNPDQ 192 + IL L Y+ + H D+K N+LL+ Sbjct: 141 LYCIEILKALNYLRKMSLTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTKSTG 200 Query: 193 VYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMI 252 + L+D+G A +K D T ++ + + + D+ G + Sbjct: 201 IKLIDFGCA----------TFKSDYHGSIINTRQYRAPEVILNLGWDVSSDMWSFGCVLA 250 Query: 253 QWLTGHLPWEDN 264 + TG L + + Sbjct: 251 ELYTGSLLFRTH 262 >6BFN-A nrPDB Length = 342 Score = 99 bits (247), Expect = 2e-21, Method: Composition-based stats. Identities = 42/245 (17%), Positives = 87/245 (35%), Gaps = 28/245 (11%) Query: 36 EWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQ 95 + L IG+GGFGC+Y A M ++ +E + F Sbjct: 23 NFSEELKIGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVKQSF-------------- 68 Query: 96 IQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYEANA---KRFSR 151 + + + + ++ + + G + ++ L+ S Sbjct: 69 LTEVEQLSRFRHPNIVDFAGY----CAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSW 124 Query: 152 KTVLQLSLRILDILEYIHEHE--YVHGDIKASNLLLNYKNPDQVYLVDYGLAY--RYCPE 207 L + L ++++H+ +HGDIK+SN+LL+ + L D+GLA R+ Sbjct: 125 PQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTP--KLGDFGLARFSRFAGS 182 Query: 208 GVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKD 267 + + GT+ + + + D G +++ L G + + Sbjct: 183 SPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQRAVKTHGAR 242 Query: 268 PKYVR 272 KY++ Sbjct: 243 TKYLK 247 >2Y4I-B nrPDB Length = 319 Score = 99.6 bits (246), Expect = 2e-21, Method: Composition-based stats. Identities = 50/310 (16%), Positives = 110/310 (35%), Gaps = 45/310 (14%) Query: 31 DMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRA 90 D+ ++ ++G IG+G FG +Y + G A ++ +E + L K ++R Sbjct: 29 DIPFEQLEIGELIGKGRFGQVYHGRWH-----GEVAIRLIDIERDNEDQL----KAFKR- 78 Query: 91 AKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYEANAKRF 149 + + R+ ++ V + G+ + +I G L + Sbjct: 79 -------EVMAYRQTRHENVVLFMGA----CMSPPHLAIITSLCKGRTLYSVVRDAKIVL 127 Query: 150 SRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGV 209 Q++ I+ + Y+H +H D+K+ N+ + +V + D+GL + Sbjct: 128 DVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYDN---GKVVITDFGL--FSISGVL 182 Query: 210 HKEYKEDPKRCHDGTIEFTSIDAH---------NGVAPSRRGDLEILGYCMIQWLTGHLP 260 +ED R +G + + + + + S+ D+ LG + P Sbjct: 183 QAGRREDKLRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWP 242 Query: 261 WEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENL 320 ++ + + M + EI+ + + E+P + L Sbjct: 243 FKTQPAEAIIWQMGTG---------MKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKL 293 Query: 321 RDILLQGLKA 330 D+L + K Sbjct: 294 MDMLEKLPKR 303 >4IAN-A nrPDB Length = 358 Score = 99.6 bits (246), Expect = 2e-21, Method: Composition-based stats. Identities = 38/244 (15%), Positives = 86/244 (35%), Gaps = 32/244 (13%) Query: 29 ITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDN---GPLFTELK 85 I ++ K + V GQG F + A ++ ++ VK+ ++ EL+ Sbjct: 24 IGEVLDKRYNVYGYTGQGVFSNVVRAR----DNARANQEVAVKIIRNNELMQKTGLKELE 79 Query: 86 FYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEAN 145 F ++ + K+ R ++ K + ++ + +L+++ + Sbjct: 80 FLKKLNDADPDDKFHCLRLFRHFYH-------------KQHLCLVFEPLSMNLREVLKKY 126 Query: 146 AK--RFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYR 203 K K V S ++ L+ + +H DIK N+L+N + L D+G A Sbjct: 127 GKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKT-ILKLCDFGSASH 185 Query: 204 YCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWED 263 + + + + G + D+ +G + + TG + + Sbjct: 186 VADNDITPYLVSRF---------YRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPG 236 Query: 264 NLKD 267 + Sbjct: 237 KTNN 240 >2PZI-A nrPDB Length = 681 Score = 99.6 bits (246), Expect = 2e-21, Method: Composition-based stats. Identities = 53/260 (20%), Positives = 93/260 (35%), Gaps = 39/260 (15%) Query: 4 VKAAQAG--RQSSAKRHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSES 61 K A G + Q G D+ +++V I GG G IYLA + Sbjct: 51 TKGASEGWCPYCGSPYSFLPQLNPG----DIVAGQYEVKGCIAHGGLGWIYLALDRN--- 103 Query: 62 VGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLH-D 120 + P V+K + +R E + + + + + H D Sbjct: 104 -VNGRPVVLKGLVHSGDAEAQAMAMAERQFLAEVV----------HPSIVQIFNFVEHTD 152 Query: 121 KNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKA 180 ++G +++M+ G Q + + ++ + L IL L Y+H V+ D+K Sbjct: 153 RHGDPVGYIVMEYVGG--QSLKRSKGQKLPVAEAIAYLLEILPALSYLHSIGLVYNDLKP 210 Query: 181 SNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSR 240 N++L + Q+ L+D G R G GT F + + P+ Sbjct: 211 ENIMLTEE---QLKLIDLGAVSRINSFGY-----------LYGTPGFQAPEIVR-TGPTV 255 Query: 241 RGDLEILGYCMIQWLTGHLP 260 D+ +G + LT LP Sbjct: 256 ATDIYTVGRTL-AALTLDLP 274 >4Y12-A nrPDB Length = 375 Score = 99.2 bits (245), Expect = 3e-21, Method: Composition-based stats. Identities = 53/260 (20%), Positives = 93/260 (35%), Gaps = 39/260 (15%) Query: 4 VKAAQAG--RQSSAKRHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSES 61 K A G + Q G D+ +++V I GG G IYLA + Sbjct: 90 TKGASEGWCPYCGSPYSFLPQLNPG----DIVAGQYEVKGCIAHGGLGWIYLALDRN--- 142 Query: 62 VGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLH-D 120 + P V+K + +R E + + + + + H D Sbjct: 143 -VNGRPVVLKGLVHSGDAEAQAMAMAERQFLAEVV----------HPSIVQIFNFVEHTD 191 Query: 121 KNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKA 180 ++G +++M+ G Q + + ++ + L IL L Y+H V+ D+K Sbjct: 192 RHGDPVGYIVMEYVGG--QSLKRSKGQKLPVAEAIAYLLEILPALSYLHSIGLVYNDLKP 249 Query: 181 SNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSR 240 N++L + Q+ L+D G R G GT F + + P+ Sbjct: 250 ENIMLTEE---QLKLIDLGAVSRINSFGY-----------LYGTPGFQAPEIVR-TGPTV 294 Query: 241 RGDLEILGYCMIQWLTGHLP 260 D+ +G + LT LP Sbjct: 295 ATDIYTVGRTL-AALTLDLP 313 >4WUA-A nrPDB Length = 401 Score = 98.4 bits (243), Expect = 5e-21, Method: Composition-based stats. Identities = 71/410 (17%), Positives = 130/410 (31%), Gaps = 101/410 (24%) Query: 28 IITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFY 87 I D+ + V +G G F ++L+ + A VVK E++ Sbjct: 34 KIGDLFNGRYHVIRKLGWGHFSTVWLSWDIQGKKF--VAMKVVKSAEHYTETALDEIRLL 91 Query: 88 Q--RAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQK-IYEA 144 + R + P + + + L + G+ + M+ + G L K I ++ Sbjct: 92 KSVRNSDPNDPNREMVVQLLDDFKISGVNGTHIC---------MVFEVLGHHLLKWIIKS 142 Query: 145 NAKRFSRKTVLQLSLRILDILEYIHEH-EYVHGDIKASNLLLNYKNP------------- 190 N + V ++ ++L L+Y+H +H DIK N+LL+ Sbjct: 143 NYQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQ 202 Query: 191 ----------------------------------DQVYLVDYGLAYRYCPEGVHKEYKED 216 +V + D G A VHK + ED Sbjct: 203 RSGAPPPSGSAVSTAPATAGNFLVNPLEPKNAEKLKVKIADLGNA-----CWVHKHFTED 257 Query: 217 PKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSK- 275 + T ++ S++ G + D+ + TG +E + +Y RD Sbjct: 258 IQ-----TRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYLFEPH-SGEEYTRDEDH 311 Query: 276 -IRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDILLQGLKAIGSK 334 E + + K E +T+K +++ + GL + Sbjct: 312 IALIIELLGKVPRKLIVAGKYSKEF-----------FTKKGDLKHITKLKPWGLFEVLV- 359 Query: 335 DDGKLDLSVVENGGLK------AKTITKKRKKEIEESKEPGVEDTEWSNT 378 K + S E G + I +KR E + P W N+ Sbjct: 360 --EKYEWSQEEAAGFTDFLLPMLELIPEKRATAAECLRHP------WLNS 401 >4LQP-A nrPDB Length = 508 Score = 97.2 bits (240), Expect = 1e-20, Method: Composition-based stats. Identities = 46/295 (15%), Positives = 87/295 (29%), Gaps = 77/295 (26%) Query: 35 KEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAA-KP 93 +++ IG+G FG + L V+ D G ++ + K Sbjct: 102 EDFHTVKVIGKGAFGEVRL------------------VQKKDTGKIYAMKTLLKSEMYKK 143 Query: 94 EQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYEANAKRFSRK 152 +Q+ R + + S + Y ++IM+ G DL + + F+ Sbjct: 144 DQLAHVKAERDVLAGSDSPWVVSLYYSFQDAQYLYLIMEFLPGGDLMTML-IRWQLFTED 202 Query: 153 TVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKE 212 + +E IH+ ++H IK N+L++ + + L D+GL+ + Sbjct: 203 VTRFYMAECILAIETIHKLGFIHRAIKPDNILIDIRG--HIKLSDFGLSTGFHKTHDSNY 260 Query: 213 YKEDPKR-------CHDGTIEFTSIDAHNGV----------------------------- 236 YK+ ++ GT + D N Sbjct: 261 YKKLLQQDEATNGISKPGTYNANTTDTANKRQTMVVDSISLTMSNRQQIQTWRKSRRLMA 320 Query: 237 ------------------APSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRD 273 + D LG M + L G P+ Y + Sbjct: 321 YSTVGTPDYIAPEIFLYQGYGQECDWWSLGAIMYECLIGWPPFCSETPQETYRKI 375 >6O6Q-A nrPDB Length = 335 Score = 97.2 bits (240), Expect = 1e-20, Method: Composition-based stats. Identities = 36/299 (12%), Positives = 95/299 (31%), Gaps = 34/299 (11%) Query: 35 KEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPE 94 + +++ +G+G + ++L + ++P + E+ + Sbjct: 41 ENYEILRKLGRGKYSEVFLGIDLEKRE----KVVIKVLKPVKRKKIKREISILKNLVDGP 96 Query: 95 QIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTV 154 I + + P +++ + +S F+ + Sbjct: 97 NIIAMLDVVREPQSKTPGLIFEHINNIDFRSLY-------------------PTFTDYDI 137 Query: 155 LQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYK 214 +L L+Y H +H D+K N++++ + + L+D+GLA Y P EY Sbjct: 138 RFYMYELLKALDYSHSMGIMHRDVKPHNVMID-HDKKLLRLIDWGLAEYYHP---GTEYN 193 Query: 215 EDPKRCHDGTIEFTSIDAH-NGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKY-VR 272 + F + + D+ G + + P+ + V+ Sbjct: 194 VRVASRY-----FKGPELLVDYRLYDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQLVQ 248 Query: 273 DSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDILLQGLKAI 331 ++ +N ++K + E Y + + + + + + L + + Sbjct: 249 IVRVLGSKNFKKYLEKYNISLGEEYEDIGYYNKRQWVRFMNENNKDLVSQEFLDLIDRL 307 >5E8V-A nrPDB Length = 316 Score = 96.9 bits (239), Expect = 1e-20, Method: Composition-based stats. Identities = 38/230 (16%), Positives = 81/230 (35%), Gaps = 36/230 (15%) Query: 43 IGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRT 102 +G+G F +Y A + + S VK+ P Y+ A + + Sbjct: 17 VGKGRFAEVYKAKLKQNTS-EQFETVAVKIFP------------YEEYASWKTEKDIFSD 63 Query: 103 RKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFG-SDLQKIYEANAKRFSRKTVLQLSLRI 161 LK+ + ++ + ++I +LQ+ + S + + +L + Sbjct: 64 INLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRH--VISWEDLRKLGSSL 121 Query: 162 LDILEYIHEHE---------YVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKE 212 + ++H VH D+K+SN+L+ KN L D+GL+ R P Sbjct: 122 ARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILV--KNDLTCCLCDFGLSLRLDPT---LS 176 Query: 213 YKEDPKRCHDGTIEFTSIDA------HNGVAPSRRGDLEILGYCMIQWLT 256 + GT + + + V ++ D+ + + + + Sbjct: 177 VDDLANSGQVGTARYMAPEVLASAMNLENVESFKQTDVYSMALVLWEMTS 226 >5UNP-A nrPDB Length = 369 Score = 96.1 bits (237), Expect = 2e-20, Method: Composition-based stats. Identities = 31/267 (11%), Positives = 88/267 (32%), Gaps = 42/267 (15%) Query: 28 IITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFY 87 + D ++ +++ +G+G FG + ++ A ++K E+ Sbjct: 27 HVGDWLQERYEIVSTLGEGTFGRVVQC-VDHRRGGARVALKIIKNVEKYKEAARLEINVL 85 Query: 88 QRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAK 147 ++ I + K + + ++ H + + G + N Sbjct: 86 EK------INEKDPDNKNLCVQMFDWFDYHGH-------MCISFELLGLSTFDFLKDNNY 132 Query: 148 -RFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKN----------------- 189 + V ++ ++ ++++H+++ H D+K N+L + Sbjct: 133 LPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVK 192 Query: 190 PDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGY 249 V +VD+G A + + T + + + + S+ D+ +G Sbjct: 193 STAVRVVDFGSA----------TFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGC 242 Query: 250 CMIQWLTGHLPWEDNLKDPKYVRDSKI 276 + ++ G ++ + +I Sbjct: 243 IIFEYYVGFTLFQTHDNREHLAMMERI 269 >3ZZW-A nrPDB Length = 289 Score = 96.1 bits (237), Expect = 3e-20, Method: Composition-based stats. Identities = 42/307 (13%), Positives = 86/307 (28%), Gaps = 47/307 (15%) Query: 28 IITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFY 87 + +++ + +G+ FG +Y + +K E + Sbjct: 2 KLKEISLSAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRH 61 Query: 88 QRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFG-SDLQKIYEANA 146 + + +L++ V G D+ MI DL + + Sbjct: 62 EAMLRA----------RLQHPNVVCLLGVVTKDQP----LSMIFSYCSHGDLHEFLVMRS 107 Query: 147 KR---------------FSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPD 191 + L +I +EY+ H VH D+ N+L+ + Sbjct: 108 PHSDVGSTDDDRTVKSALEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLV--YDKL 165 Query: 192 QVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCM 251 V + D GL +K I + + +A S D+ G + Sbjct: 166 NVKISDLGLFREVYAADYYKLLGNSLL-----PIRWMAPEAIMYGKFSIDSDIWSYGVVL 220 Query: 252 IQ-WLTGHLPWEDNLKDPKYVRDSKIRYRENI-------ASLMDKCFPEKNKPGEIAKYM 303 + + G P+ + +LM +C+ E P ++ Sbjct: 221 WEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCPDDCPAWVYALMIECWNE--FPSRRPRFK 278 Query: 304 ETVKLLD 310 + L Sbjct: 279 DIHSRLR 285 >6FER-A nrPDB Length = 309 Score = 95.7 bits (236), Expect = 3e-20, Method: Composition-based stats. Identities = 46/307 (14%), Positives = 108/307 (35%), Gaps = 41/307 (13%) Query: 40 GLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQ----RAAKPEQ 95 +G+G FG ++L ++ E + ++ S N P+ +K + + A+ + Sbjct: 14 KEKLGEGQFGEVHLCEV---EGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDF 70 Query: 96 IQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYEANAKRFSRKTV 154 +++ +LK + + D MI + DL + + S + Sbjct: 71 LKEIKIMSRLKDPNIIHLLAVCITDDP----LCMITEYMENGDLNQFLSRHEPPNSSSSD 126 Query: 155 LQ---------LSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYC 205 ++ ++ +I ++Y+ +VH D+ N L+ + + D+G++ Sbjct: 127 VRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKN--YTIKIADFGMSRNLY 184 Query: 206 PEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNL 265 Y+ + I + S ++ + D+ G + + T Sbjct: 185 SGD---YYRIQGRAVL--PIRWMSWESILLGKFTTASDVWAFGVTLWETFT-------FC 232 Query: 266 KDPKYVRDSKIRYRENIASLMDKCFPEKNKPG------EIAKYMETVKLLDYTEKPLYEN 319 ++ Y + S + EN + P + K M + D +P ++ Sbjct: 233 QEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQE 292 Query: 320 LRDILLQ 326 + +LLQ Sbjct: 293 IHLLLLQ 299 >5OAT-A nrPDB Length = 411 Score = 92.6 bits (228), Expect = 3e-19, Method: Composition-based stats. Identities = 48/268 (17%), Positives = 91/268 (33%), Gaps = 40/268 (14%) Query: 32 MAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKV--EPSDNGPLFTELKFYQR 89 + + +G PI +G G +Y A + E+ + P +K+ LK R Sbjct: 8 ITLNDLSLGKPIAKGTNGVVYSAKVKDDETDDNKYPFALKMMFNYDIQENSMEILKAMYR 67 Query: 90 AAKPE------------QIQKWIRTRKLK-YLGVPKYWG-----------SGLHDKNGKS 125 P +I+ R + L + + + LH + Sbjct: 68 ETVPARMYYSNHDLNNWEIELANRRKHLPPHPNIVAIFSVFTDLYPAALPPRLHPEGEGR 127 Query: 126 Y--RFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNL 183 F++M R+ +LQ S +T L L ++L+ + ++ H H D+K+ NL Sbjct: 128 NMSLFLLMKRYDCNLQSFLSTAP---STRTSLLLLAQLLEGVAHMTAHGIAHRDLKSDNL 184 Query: 184 LLNYKNPDQ--VYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSR- 240 LL+ P+ + + D+G G+ Y G + + + Sbjct: 185 LLDTSEPESPILVISDFGCCLADKTNGLSLPYTSYE-MDKGGNTALMAPEIICQKPGTFS 243 Query: 241 -----RGDLEILGYCMIQWLTGHLPWED 263 + DL +G + H P+ Sbjct: 244 VLNYSKADLWAVGAIAYEIFNCHNPFYG 271 >3G2F-A nrPDB Length = 336 Score = 92.6 bits (228), Expect = 3e-19, Method: Composition-based stats. Identities = 52/308 (16%), Positives = 104/308 (33%), Gaps = 53/308 (17%) Query: 30 TDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQR 89 + K+ IG+G +G +Y ++ P VKV N F K Sbjct: 8 PSLDLDNLKLLELIGRGRYGAVYKGSLDE-------RPVAVKVFSFANRQNFINEK---- 56 Query: 90 AAKPEQIQKWIRTRKLKYLGVPKYW-GSGLHDKNGKSYRFMIMDRF-GSDLQKIYEANAK 147 R +++ + ++ G +G+ ++M+ + L K + Sbjct: 57 --------NIYRVPLMEHDNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTS 108 Query: 148 RFSRKTVLQLSLRILDILEYIHEH---------EYVHGDIKASNLLLNYKNPDQVYLVDY 198 + + +L+ + L Y+H H D+ + N+L+ KN + D+ Sbjct: 109 DW--VSSCRLAHSVTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLV--KNDGTCVISDF 164 Query: 199 GLAYRYCPEGVHKEYKED-PKRCHDGTIEFTSIDAHNG-------VAPSRRGDLEILGYC 250 GL+ R + + +ED GTI + + + G + ++ D+ LG Sbjct: 165 GLSMRLTGNRLVRPGEEDNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLI 224 Query: 251 MIQW---LTGHLPWEDNLKDPKYVRDSKIRYR-----ENIASLMDKCFPEKNKPGEIAKY 302 + T P E P+Y + E++ L+ + P + Sbjct: 225 YWEIFMRCTDLFPGE---SVPEYQMAFQTEVGNHPTFEDMQVLVSREKQRPKFPEAWKEN 281 Query: 303 METVKLLD 310 V+ L Sbjct: 282 SLAVRSLK 289 >3SOC-A nrPDB Length = 322 Score = 91.8 bits (226), Expect = 5e-19, Method: Composition-based stats. Identities = 45/275 (16%), Positives = 91/275 (33%), Gaps = 58/275 (21%) Query: 45 QGGFGCIYLADMNSSESVGSDAPCVVKVEP-SDNGPLFTELKFYQRAAKPEQIQKWIRTR 103 +G FGC++ A + + VK+ P D E + Y Sbjct: 34 RGRFGCVWKAQLLNE-------YVAVKIFPIQDKQSWQNEYEVYS-------------LP 73 Query: 104 KLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFG-SDLQKIYEANAKRFSRKTVLQLSLRIL 162 +K+ + ++ G+ + ++I L +AN S + ++ + Sbjct: 74 GMKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKAN--VVSWNELCHIAETMA 131 Query: 163 DILEYIHEH----------EYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKE 212 L Y+HE H DIK+ N+LL KN + D+GLA ++ Sbjct: 132 RGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLL--KNNLTACIADFGLALKFEAGK---- 185 Query: 213 YKEDPKRCHDGTIEFTSIDAHNG-----VAPSRRGDLEILGYCMIQWLTGH--------- 258 GT + + + G R D+ +G + + + Sbjct: 186 -SAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDE 244 Query: 259 --LPWEDNL-KDPKYVRDSKIRYRENIASLMDKCF 290 LP+E+ + + P ++ + ++ + Sbjct: 245 YMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYW 279 >4M66-A nrPDB Length = 325 Score = 91.8 bits (226), Expect = 5e-19, Method: Composition-based stats. Identities = 48/297 (16%), Positives = 99/297 (33%), Gaps = 35/297 (11%) Query: 29 ITDMAKKEWKVGLPIGQGGFGCIYLADMNS-SESVGSDAPCVVKVEPSDNGPLFTELKFY 87 + ++++E K +G+GGFG ++ A + + V K+ E+K Sbjct: 14 VPLVSREELKKLEFVGKGGFGVVFRAHHRTWNHDVAVKIVNSKKIS--------WEVKAM 65 Query: 88 QRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAK 147 + T L++ D GS + + Sbjct: 66 VNLRNENVLLLLGVTEDLQW------------DFVSGQALVTRFMENGSLAGLLQPEAPR 113 Query: 148 RFSRKTVLQLSLRILDILEYIHEHE--YVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYC 205 + + +L ++ + Y+H + +H D+K SN+LL+ + L D+GL+ + Sbjct: 114 PWPL--LCRLLQEVVLGMCYLHSLDPPLLHRDLKPSNILLDPEL--HAKLADFGLST-FQ 168 Query: 206 PEGVHKEYKEDPKRCHDGTIEFTSIDAHNGV--APSRRGDLEILGYCMIQWLTGHLPWED 263 R GT+ + + V S+ D+ G + L G E Sbjct: 169 GGSQSGSGSGSGSRDSGGTLAYLDPELLFKVNLKASKASDVYSFGILVWAVLAGR---EA 225 Query: 264 NLKDPKYVRDSKIRYRENIASLMDKCFPEKNKP--GEIAKYMETVKLLDYTEKPLYE 318 L D + + R++ L + P ++ + M +P ++ Sbjct: 226 ELVDKTSLIRETVCDRQSRPPLTELPPGSPETPGLEKLKELMIHCWGSQSENRPSFQ 282 >3MDY-A nrPDB Length = 337 Score = 91.5 bits (225), Expect = 7e-19, Method: Composition-based stats. Identities = 42/301 (13%), Positives = 97/301 (32%), Gaps = 52/301 (17%) Query: 32 MAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAA 91 K+ ++ IG+G +G +++ E V ++ F E + YQ Sbjct: 34 TIAKQIQMVKQIGKGRYGEVWMGKWR-GEKVAVKVFFT-----TEEASWFRETEIYQTVL 87 Query: 92 KPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYEANAKRFS 150 +++ + + + + + ++I D L ++ Sbjct: 88 -------------MRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKST--TLD 132 Query: 151 RKTVLQLSLRILDILEYIHEH--------EYVHGDIKASNLLLNYKNPDQVYLVDYGLAY 202 K++L+L+ + L ++H H D+K+ N+L+ + D GLA Sbjct: 133 AKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCC--IADLGLAV 190 Query: 203 RYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHN-----GVAPSR-RGDLEILGYCMIQWLT 256 ++ + + + + GT + + + S D+ G + + Sbjct: 191 KFISDTNEVDIPPNTR---VGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVAR 247 Query: 257 GH----------LPWEDNLK-DPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMET 305 LP+ D + DP Y +I + + + ++ K M Sbjct: 248 RCVSGGIVEEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTE 307 Query: 306 V 306 Sbjct: 308 C 308 >6DC0-A nrPDB Length = 292 Score = 91.1 bits (224), Expect = 9e-19, Method: Composition-based stats. Identities = 26/158 (16%), Positives = 62/158 (39%), Gaps = 10/158 (6%) Query: 123 GKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASN 182 G++ ++ ++ D+ Y + KR + +L +I+ + + H+ V GD+K Sbjct: 69 GETKAYVFFEKDFGDMHS-YVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRK 127 Query: 183 LLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHN--GVAPSR 240 + + + Q+ L + + ++D G + S + N G + Sbjct: 128 FVFSTEERTQLRL-------ESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGK 180 Query: 241 RGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRY 278 D+ LG + L G P+ D+ + + + ++ Sbjct: 181 AADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQF 218 >5CEK-A nrPDB Length = 263 Score = 90.3 bits (222), Expect = 1e-18, Method: Composition-based stats. Identities = 26/158 (16%), Positives = 62/158 (39%), Gaps = 10/158 (6%) Query: 123 GKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASN 182 G++ ++ ++ D+ Y + KR + +L +I+ + + H+ V GD+K Sbjct: 72 GETKAYVFFEKDFGDMHS-YVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRK 130 Query: 183 LLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHN--GVAPSR 240 + + + Q+ L + + ++D G + S + N G + Sbjct: 131 FVFSTEERTQLRL-------ESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGK 183 Query: 241 RGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRY 278 D+ LG + L G P+ D+ + + + ++ Sbjct: 184 AADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQF 221 >4RT7-A nrPDB Length = 415 Score = 90.3 bits (222), Expect = 1e-18, Method: Composition-based stats. Identities = 49/326 (15%), Positives = 102/326 (31%), Gaps = 77/326 (23%) Query: 40 GLPIGQGGFGCIYLADMNSSESVGSDAPCVVKV-----EPSDNGPLFTELKFYQRAAKPE 94 G +G G FG + A G VK+ + S+ L +ELK + E Sbjct: 70 GKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHE 129 Query: 95 QIQKWIRTRKLKYLGVPKY----WGSGLHDKNGKSYRF---------------------- 128 I + L + +G L+ K +F Sbjct: 130 NIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSH 189 Query: 129 ------------------MIMDRFGSDLQ---KIYEANAKRFSRKTVLQL---------S 158 I G+ +I N KR + L + + Sbjct: 190 PNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFA 249 Query: 159 LRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPK 218 ++ +E++ VH D+ A N+L+ + V + D+GLA + + + Sbjct: 250 YQVAKGMEFLEFKSCVHRDLAARNVLVTHGK--VVKICDFGLAR-----DIMSDSNYVVR 302 Query: 219 RCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT-GHLPWEDNLKDPKYVRDSKIR 277 +++ + ++ + + D+ G + + + G P+ D + + + Sbjct: 303 GNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNG 362 Query: 278 YR--------ENIASLMDKCFPEKNK 295 ++ E I +M C+ ++ Sbjct: 363 FKMDQPFYATEEIYIIMQSCWAFDSR 388 >5M07-A nrPDB Length = 276 Score = 89.5 bits (220), Expect = 2e-18, Method: Composition-based stats. Identities = 38/254 (14%), Positives = 82/254 (32%), Gaps = 42/254 (16%) Query: 19 LAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNG 78 L + + + + + + V +G G +YL G +KV Sbjct: 14 LVPRGSHMALASGVTFAGYTVVRMLGASAMGEVYLVQHP-----GFPGWQALKVLS---P 65 Query: 79 PLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGS-- 136 + + +F +R + ++ +L + + + G D ++ MD Sbjct: 66 AMAADDEFRRRFQRETEV-----AARLFHPHILEVHDRGEFDGQ----LWIAMDYVDGID 116 Query: 137 DLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYK--NPDQVY 194 Q + + VL + + L+Y H+ +H D+ +N++L + ++ Sbjct: 117 ATQHMADRFPAVLPVGEVLAIVTAVAGALDYAHQRGLLHRDVNPANVVLTSQSAGDQRIL 176 Query: 195 LVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQW 254 L D+G+A + + + + G R D L I Sbjct: 177 LADFGIASQ---------------------PSYPAPELSAGADVDGRADQYALALTAIHL 215 Query: 255 LTGHLPWEDNLKDP 268 G P + + P Sbjct: 216 FAGAPPVDRSHTGP 229 >4LFI-A nrPDB Length = 374 Score = 89.5 bits (220), Expect = 2e-18, Method: Composition-based stats. Identities = 40/295 (13%), Positives = 94/295 (31%), Gaps = 38/295 (12%) Query: 35 KEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVV-------------------KVEPS 75 K++++ +G+G + ++ S+ KV P+ Sbjct: 40 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPT 99 Query: 76 DNGPLFTELKFYQRAAKPEQIQK-WIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF 134 + Q+ + I+ + + + + ++ + Sbjct: 100 TLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFD--IIKDPISKTPALVFEYV 157 Query: 135 GSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVY 194 + +I + + + +L L+Y H +H D+K N+++++KN ++ Sbjct: 158 DNVDFRIL---YPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNK-KLR 213 Query: 195 LVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAH-NGVAPSRRGDLEILGYCMIQ 253 L+D+GLA Y V+ EY F + + DL G + Sbjct: 214 LIDWGLAEFY---HVNMEYNVRVASRF-----FKGPELLVDYRMYDYSLDLWSFGTMLAS 265 Query: 254 WLTGHLPWEDNLKDPKY-VRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVK 307 + P+ + V+ K+ + + K E P E + ++ Sbjct: 266 MIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLK--YEITLPREFYDMDQYIR 318 >4MD7-E nrPDB Length = 391 Score = 88.8 bits (218), Expect = 4e-18, Method: Composition-based stats. Identities = 40/258 (15%), Positives = 96/258 (37%), Gaps = 38/258 (14%) Query: 35 KEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKP 93 ++++ +G+G + ++ A ++ ++E V VK + E Sbjct: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILE---------- 86 Query: 94 EQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFG-SDLQKIYEANAKRFSRK 152 ++ L + ++ + +D +++Y + + Sbjct: 87 -NLRGGPNIITLADIV----------KDPVSRTPALVFEHVNNTDFKQLY----QTLTDY 131 Query: 153 TVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKE 212 + IL L+Y H +H D+K N+++++++ ++ L+D+GLA Y P +E Sbjct: 132 DIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHR-KLRLIDWGLAEFYHP---GQE 187 Query: 213 YKEDPKRCHDGTIEFTSIDAH-NGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKD-PKY 270 Y + F + + D+ LG + + P+ + + Sbjct: 188 YNVRVASRY-----FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQL 242 Query: 271 VRDSKIRYRENIASLMDK 288 VR +K+ E++ +DK Sbjct: 243 VRIAKVLGTEDLYDYIDK 260 >6HMD-A nrPDB Length = 365 Score = 88.8 bits (218), Expect = 4e-18, Method: Composition-based stats. Identities = 42/256 (16%), Positives = 95/256 (37%), Gaps = 34/256 (13%) Query: 35 KEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPE 94 ++++ +G+G + ++ A ++ ++ V ++P + E+K + Sbjct: 53 DDYQLVRKLGRGKYSEVFEAINITN----NERVVVKILKPVKKKKIKREVKILENLRGGT 108 Query: 95 QIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTV 154 I K I T K P +++ + K ++ D + Sbjct: 109 NIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDF-------------------DI 149 Query: 155 LQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYK 214 +L L+Y H +H D+K N++++++ ++ L+D+GLA Y P +EY Sbjct: 150 RFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQ-QKKLRLIDWGLAEFYHPA---QEYN 205 Query: 215 EDPKRCHDGTIEFTSIDAH-NGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKD-PKYVR 272 + F + + D+ LG + + P+ + + VR Sbjct: 206 VRVASRY-----FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVR 260 Query: 273 DSKIRYRENIASLMDK 288 +K+ E + + K Sbjct: 261 IAKVLGTEELYGYLKK 276 >3Q4U-A nrPDB Length = 301 Score = 88.4 bits (217), Expect = 5e-18, Method: Composition-based stats. Identities = 45/301 (14%), Positives = 97/301 (32%), Gaps = 52/301 (17%) Query: 32 MAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAA 91 ++ + +G+G +G ++ E+V D F E + Y Sbjct: 5 TVARDITLLECVGKGRYGEVWRGS-WQGENVAVKI-----FSSRDEKSWFRETELY---- 54 Query: 92 KPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFG-SDLQKIYEANAKRFS 150 T L++ + + S + ++ + ++I L Sbjct: 55 ---------NTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYL--QLTTLD 103 Query: 151 RKTVLQLSLRILDILEYIH--------EHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAY 202 + L++ L I L ++H + H D+K+ N+L+ K Q + D GLA Sbjct: 104 TVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILV--KKNGQCCIADLGLAV 161 Query: 203 RYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAP------SRRGDLEILGYCMIQWLT 256 + + +P+ GT + + + + +R D+ G + + Sbjct: 162 MHSQSTNQLDVGNNPR---VGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVAR 218 Query: 257 -----G-----HLPWEDNLK-DPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMET 305 G P+ D + DP + K+ + + + +AK M+ Sbjct: 219 RMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKE 278 Query: 306 V 306 Sbjct: 279 C 279 >5XVU-A nrPDB Length = 332 Score = 87.2 bits (214), Expect = 1e-17, Method: Composition-based stats. Identities = 38/228 (16%), Positives = 84/228 (36%), Gaps = 33/228 (14%) Query: 35 KEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPE 94 +++ IG+G + ++ N ++ + + ++P + E+K Q Sbjct: 31 NRYEIMKKIGRGKYSEVF----NGYDTECNRPCAIKVLKPVKKKKIKREIKILQNLNGGP 86 Query: 95 QIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTV 154 I K + K P +++ + K+ +F+ K + Sbjct: 87 NIIKLLDIVKDPVTKTPSLIFEYINNIDFKTLY-------------------PKFTDKDI 127 Query: 155 LQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYK 214 +IL L+Y H +H D+K N++++++N Q+ L+ +GLA Y P +EY Sbjct: 128 RYYIYQILKALDYCHSQGIMHRDVKPHNIMIDHENR-QIRLISWGLAEFYHP---GQEYN 183 Query: 215 EDPKRCHDGTIEFTSID-AHNGVAPSRRGDLEILGYCMIQWLTGHLPW 261 + + + + D+ LG + + P+ Sbjct: 184 VRVASRY-----YKGPELLIDLQLYDYSLDIWSLGCMLAGMIFKKEPF 226 >5X1R-A nrPDB Length = 302 Score = 87.2 bits (214), Expect = 1e-17, Method: Composition-based stats. Identities = 37/228 (16%), Positives = 80/228 (35%), Gaps = 8/228 (3%) Query: 35 KEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKV-EPSDNGPLFTELKFYQRAAK 92 E+++ IG+GGFG +Y A D ++ + + +D+ + + + + + Sbjct: 21 NEFEIQEAIGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAKRNDDLSIGLRGERFGKTFQ 80 Query: 93 PEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRK 152 R L P + + G+ L+ + ++ Sbjct: 81 AGLNSFIQEARLLARFSHPGLLHVLRFWEENGTAYMGTQFYSGTTLKNLQAQQPEKIDEA 140 Query: 153 TVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKE 212 + +L + + IH+ Y+H DI N+ + L+D+G A + + E Sbjct: 141 WIRRLLPPLFSAINTIHQEGYLHRDISLDNIQIQESQLPV--LLDFGSARKEI-GNLSDE 197 Query: 213 YKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLP 260 + K ++T + +G D+ LG + + G P Sbjct: 198 TEIVLKPGFAPIEQYT--ENSDG-EQGPWTDIYALGAVLHTLIVGSPP 242 >6EII-A nrPDB Length = 352 Score = 86.5 bits (212), Expect = 2e-17, Method: Composition-based stats. Identities = 40/258 (15%), Positives = 96/258 (37%), Gaps = 38/258 (14%) Query: 35 KEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKP 93 ++++ +G+G + ++ A ++ ++E V VK + E Sbjct: 60 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILE---------- 109 Query: 94 EQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFG-SDLQKIYEANAKRFSRK 152 ++ L + ++ + +D +++Y + + Sbjct: 110 -NLRGGPNIITLADIV----------KDPVSRTPALVFEHVNNTDFKQLY----QTLTDY 154 Query: 153 TVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKE 212 + IL L+Y H +H D+K N+++++++ ++ L+D+GLA Y P +E Sbjct: 155 DIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHR-KLRLIDWGLAEFYHP---GQE 210 Query: 213 YKEDPKRCHDGTIEFTSIDAH-NGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKD-PKY 270 Y + F + + D+ LG + + P+ + + Sbjct: 211 YNVRVASRY-----FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQL 265 Query: 271 VRDSKIRYRENIASLMDK 288 VR +K+ E++ +DK Sbjct: 266 VRIAKVLGTEDLYDYIDK 283 >2PVN-A nrPDB Length = 352 Score = 86.5 bits (212), Expect = 2e-17, Method: Composition-based stats. Identities = 35/229 (15%), Positives = 79/229 (34%), Gaps = 35/229 (15%) Query: 35 KEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKP 93 +++V +G+G + ++ ++N++E + E+K Q Sbjct: 52 DDYEVVRKVGRGKYSEVFEGINVNNNEKCIIKILKP-----VKKKKIKREIKILQNLCGG 106 Query: 94 EQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKT 153 I K + + ++ P +++ + K + Sbjct: 107 PNIVKLLDIVRDQHSKTPSLIFEYVNNTDFKVLY-------------------PTLTDYD 147 Query: 154 VLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEY 213 + +L L+Y H +H D+K N++++++ ++ L+D+GLA Y P KEY Sbjct: 148 IRYYIYELLKALDYCHSQGIMHRDVKPHNVMIDHELR-KLRLIDWGLAEFYHP---GKEY 203 Query: 214 KEDPKRCHDGTIEFTSIDAH-NGVAPSRRGDLEILGYCMIQWLTGHLPW 261 + F + + D+ LG + P+ Sbjct: 204 NVRVASRY-----FKGPELLVDLQDYDYSLDMWSLGCMFAGMIFRKEPF 247 >2QLU-A nrPDB Length = 314 Score = 85.7 bits (210), Expect = 4e-17, Method: Composition-based stats. Identities = 42/275 (15%), Positives = 91/275 (33%), Gaps = 57/275 (20%) Query: 45 QGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRK 104 +G FGC++ A + + VK+ P Q + ++ T Sbjct: 25 RGRFGCVWKAQLMND-------FVAVKIFP------------LQDKQSWQSEREIFSTPG 65 Query: 105 LKYLGVPKYWGSGLHDKNGKSYRFMIMDRFG-SDLQKIYEANAKRFSRKTVLQLSLRILD 163 +K+ + ++ + N + ++I L + + + ++ + Sbjct: 66 MKHENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLK--GNIITWNELCHVAETMSR 123 Query: 164 ILEYIHEH-----------EYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKE 212 L Y+HE H D K+ N+LL K+ L D+GLA R+ P Sbjct: 124 GLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLL--KSDLTAVLADFGLAVRFEPGK---- 177 Query: 213 YKEDPKRCHDGTIEFTSIDAHNG-----VAPSRRGDLEILGYCMIQWLTGH--------- 258 GT + + + G R D+ +G + + ++ Sbjct: 178 -PPGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDE 236 Query: 259 --LPWEDNL-KDPKYVRDSKIRYRENIASLMDKCF 290 LP+E+ + + P ++ + + + + Sbjct: 237 YMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDHW 271 >1PY5-A nrPDB Length = 326 Score = 85.3 bits (209), Expect = 4e-17, Method: Composition-based stats. Identities = 43/294 (14%), Positives = 92/294 (31%), Gaps = 52/294 (17%) Query: 39 VGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQK 98 + IG+G FG ++ E + F E + YQ Sbjct: 33 LQESIGKGRFGEVWRGKWRGEEVAVKI------FSSREERSWFREAEIYQ---------- 76 Query: 99 WIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFG-SDLQKIYEANAKRFSRKTVLQL 157 T L++ + + + D + +++ D L + + +++L Sbjct: 77 ---TVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNR--YTVTVEGMIKL 131 Query: 158 SLRILDILEYIH--------EHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGV 209 +L L ++H + H D+K+ N+L+ + D GLA R+ Sbjct: 132 ALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCC--IADLGLAVRHDSATD 189 Query: 210 HKEYKEDPKRCHDGTIEFTSIDAHNGV------APSRRGDLEILGYCMIQWLTGH----- 258 + + + GT + + + + +R D+ +G + Sbjct: 190 TIDIAPNHR---VGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGI 246 Query: 259 -----LPWEDNLK-DPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETV 306 LP+ D + DP K+ + + + + +AK M Sbjct: 247 HEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMREC 300 >5AR8-A nrPDB Length = 326 Score = 84.5 bits (207), Expect = 7e-17, Method: Composition-based stats. Identities = 47/295 (15%), Positives = 96/295 (32%), Gaps = 50/295 (16%) Query: 41 LPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELK-FYQRAAKPEQIQKW 99 + +G G + +S+ VK L +E K + A + + Sbjct: 38 RYLSRGASGTV-----SSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFS 92 Query: 100 IRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYEANAKRFSRKTVLQL- 157 L P++ G ++ + L ++ + L+ Sbjct: 93 YILPILGICNEPEFLG-------------IVTEYMPNGSLNELLHRKTEYPDVAWPLRFR 139 Query: 158 -SLRILDILEYIHEHE--YVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYK 214 I + Y+H +H D+K N+LL+ N V + D+GL+ Sbjct: 140 ILHEIALGVNYLHNMTPPLLHHDLKTQNILLD--NEFHVKIADFGLSKWRMMSLSQSRSS 197 Query: 215 EDPKRCHDGTIEFTSIDAHNGVAPSRRG---DLEILGYCMIQWLTGHLPWEDNLKDPKYV 271 + GTI + + + SR D+ + L+ P+ED + +P + Sbjct: 198 KSAPEG--GTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFED-VTNPLQI 254 Query: 272 RDS----------------KIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLD 310 S I +R + SL++ + + P E +++ + L+ Sbjct: 255 MYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQN--PDERPSFLKCLIELE 307 >6EQI-C nrPDB Length = 433 Score = 83.8 bits (205), Expect = 1e-16, Method: Composition-based stats. Identities = 41/305 (13%), Positives = 90/305 (29%), Gaps = 49/305 (16%) Query: 27 EIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKV--EPSDNGPLFTEL 84 E + E +G PI +G +Y A + + +S VK+ L Sbjct: 7 EQLQAANLDELDLGEPIAKGCNAVVYSAKLKNVQSNKLAHQLAVKMMFNYDVESNSTAIL 66 Query: 85 KFYQRAAKPEQIQ------------KWIRTRKLKYLGVPKYWGSGLHDKNGKSYR----- 127 K R P + R + + + + Sbjct: 67 KAMYRETVPAMSYFFNQNLFNIENISDFKIRLPPHPNIVRMYSVFADRIPDLQCNKQLYP 126 Query: 128 ------------------FMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIH 169 F++M R+ L++ ++ + L ++L+ + +++ Sbjct: 127 EALPPRINPEGSGRNMSLFLVMKRYDCTLKEYLRDKTPNM--RSSILLLSQLLEAVAHMN 184 Query: 170 EHEYVHGDIKASNLLLNYKNPDQ---VYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIE 226 H H D+K+ N+L++ D + + D+G G+ Y+ + G Sbjct: 185 IHNISHRDLKSDNILVDLSEGDAYPTIVITDFGCCLCDKQNGLVIPYR-SEDQDKGGNRA 243 Query: 227 FTSIDAHNGVAPSR------RGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRYRE 280 + + N + + DL +G + P+ D + E Sbjct: 244 LMAPEIANAKPGTFSWLNYKKSDLWAVGAIAYEIFNIDNPFYDKTMKLLSKSYKEEDLPE 303 Query: 281 NIASL 285 ++ Sbjct: 304 LPDTI 308 >4BTF-A nrPDB Length = 469 Score = 83.4 bits (204), Expect = 2e-16, Method: Composition-based stats. Identities = 31/226 (13%), Positives = 79/226 (34%), Gaps = 18/226 (7%) Query: 98 KWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFG-SDLQKIYEANAKRFSRKTVLQ 156 + +K + + +G + ++M+ L+++ + K + Sbjct: 244 EIKTMKKFDSPNILRIFGICIDQTVKPPEFSIVMEYCELGTLRELLDRE-KDLTMSVRSL 302 Query: 157 LSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKED 216 L LR L +H E +H +I +S+ L+ QV L + L+ + + Sbjct: 303 LVLRAARGLYRLHHSETLHRNISSSSFLV--AGGYQVKLAGFELSKTQNSISRTAKSTKA 360 Query: 217 PKRCHDGTIEFTSIDAHNGVAP--SRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDS 274 + + S + + ++ G + + TG +P+E D K +R Sbjct: 361 ERSSST---IYVSPERLKNPFCLYDIKAEIYSFGIVLWEIATGKIPFEGC--DSKKIR-E 414 Query: 275 KIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENL 320 + + + C P + + + + + +++P + + Sbjct: 415 LVAEDKKQEPVGQDC------PELLREIINECRAHEPSQRPSVDGI 454 >4M69-B nrPDB Length = 283 Score = 83.0 bits (203), Expect = 2e-16, Method: Composition-based stats. Identities = 31/226 (13%), Positives = 79/226 (34%), Gaps = 18/226 (7%) Query: 98 KWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFG-SDLQKIYEANAKRFSRKTVLQ 156 + +K + + +G + ++M+ L+++ + K + Sbjct: 58 EIKTMKKFDSPNILRIFGICIDQTVKPPEFSIVMEYCELGTLRELLDRE-KDLTMSVRSL 116 Query: 157 LSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKED 216 L LR L +H E +H +I +S+ L+ QV L + L+ + + Sbjct: 117 LVLRAARGLYRLHHSETLHRNISSSSFLV--AGGYQVKLAGFELSKTQNSISRTAKSTKA 174 Query: 217 PKRCHDGTIEFTSIDAHNGVAP--SRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDS 274 + + S + + ++ G + + TG +P+E D K +R Sbjct: 175 ERSSST---IYVSPERLKNPFCLYDIKAEIYSFGIVLWEIATGKIPFEGC--DSKKIR-E 228 Query: 275 KIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENL 320 + + + C P + + + + + +++P + + Sbjct: 229 LVAEDKKQEPVGQDC------PELLREIINECRAHEPSQRPSVDGI 268 >3MY0-A nrPDB Length = 305 Score = 82.6 bits (202), Expect = 3e-16, Method: Composition-based stats. Identities = 43/281 (15%), Positives = 94/281 (33%), Gaps = 52/281 (18%) Query: 32 MAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAA 91 ++ + +G+G +G ++ + ESV D F E + Y Sbjct: 5 TVARQVALVECVGKGRYGEVWRG-LWHGESVAVKI-----FSSRDEQSWFRETEIY---- 54 Query: 92 KPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFG-SDLQKIYEANAKRFS 150 T L++ + + S + +N + ++I L + + Sbjct: 55 ---------NTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQR--QTLE 103 Query: 151 RKTVLQLSLRILDILEYIH--------EHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAY 202 L+L++ L ++H + H D K+ N+L+ K+ Q + D GLA Sbjct: 104 PHLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLV--KSNLQCCIADLGLAV 161 Query: 203 RYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNG-----VAPSRR-GDLEILGYCMIQWLT 256 + + + +P+ GT + + + + S + D+ G + + Sbjct: 162 MHSQGSDYLDIGNNPR---VGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIAR 218 Query: 257 -----G-----HLPWEDNLK-DPKYVRDSKIRYRENIASLM 286 G P+ D + DP + K+ + + Sbjct: 219 RTIVNGIVEDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTI 259 >4L00-A nrPDB Length = 304 Score = 81.8 bits (200), Expect = 4e-16, Method: Composition-based stats. Identities = 55/340 (16%), Positives = 114/340 (33%), Gaps = 55/340 (16%) Query: 13 SSAKRHLAEQFAVGEIITDMAKKEWKV-GLPIGQGGFGCIY---LADMNSSESVGSDAPC 68 S++ + + + ++ D K+ V G +G+G IY L D E + Sbjct: 2 STSAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKI 61 Query: 69 VVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRF 128 V ++ D L F++ A+ R++ + + +G + D Sbjct: 62 KVILKVLDPSHRDISLAFFEAASM---------MRQVSHKHIVYLYGVCVRDVE----NI 108 Query: 129 MIMDRF-GSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY 187 M+ + G L + + +++ ++ L Y+ + + VHG++ NLLL Sbjct: 109 MVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAR 168 Query: 188 KNPDQ-----VYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSID-AHNGVAPSRR 241 + D + L D G+ ++ I + + + + S Sbjct: 169 EGIDSECGPFIKLSDPGI-----------PITVLSRQECIERIPWIAPECVEDSKNLSVA 217 Query: 242 GDLEILGYCMIQWLT-GHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIA 300 D G + + G +P +D K R+ E+ +C P E+A Sbjct: 218 ADKWSFGTTLWEICYNGEIPLKD------KTLIEKERFYES------RCRPVTPSCKELA 265 Query: 301 KYMETVKLLDYTEKPLYENLRDILLQGLKAIGSKDDGKLD 340 M D ++P ++ I ++ D Sbjct: 266 DLMTRCMNYDPNQRP-------FFRAIMRDINKLEEQNPD 298 >4JRN-A nrPDB Length = 372 Score = 79.9 bits (195), Expect = 2e-15, Method: Composition-based stats. Identities = 44/235 (18%), Positives = 78/235 (33%), Gaps = 35/235 (14%) Query: 39 VGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNG--PLFTELKFYQRAAKPEQ 95 G P+G GGF +Y A D+ ++E + K EP+D L E Y+ + + Sbjct: 72 RGAPLGSGGFATVYEATDVETNEELAVKVFMSEK-EPTDETMLDLQRESSCYRNFSLAKT 130 Query: 96 IQKWIRTRKLKYLGVPKYWGSGLHDKNGK--------SYRFMIMDRFGSDLQKIYEA--- 144 + + + F++M R +D+ K+ Sbjct: 131 AKDAQESCRFMVPSDVVMLEGQPASTEVVIGLTTRWVPNYFLLMMRAEADMSKVISWVFG 190 Query: 145 ----NAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGL 200 N F + LS + + ++ + VH DIK +N LL +++L D+G Sbjct: 191 DASVNKSEFGLVVRMYLSSQAIKLVANVQAQGIVHTDIKPANFLLLKDG--RLFLGDFGT 248 Query: 201 AYRYCPEGVHKEYKEDPKRCHDGTIEFTSID---AHNGVAPSRRGDLEILGYCMI 252 G GT + + G+ + D LG + Sbjct: 249 YRINNSVGR-----------AIGTPGYEPPERPFQATGITYTFPTDAWQLGITLY 292 >4IX6-A nrPDB Length = 350 Score = 78.0 bits (190), Expect = 7e-15, Method: Composition-based stats. Identities = 38/236 (16%), Positives = 72/236 (30%), Gaps = 21/236 (8%) Query: 42 PIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIR 101 P+G G FG ++ + V + + ++ ++ A +++ Sbjct: 27 PLGSGNFGTVFRGVFKGDQDVVLKNAKADVMAAEELLECEMDVNYHVHANAKGTCARFMG 86 Query: 102 TRKLKYLGVPKYWGSGLHD------KNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVL 155 +L + + L + N + R G+ A A Sbjct: 87 CIELGAKDGGEIYNGTLTEGLWLMWANEGENTVEALMRRGTAPLATAMACADATELGVTK 146 Query: 156 QLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEY-- 213 + +L L +HE VH D+K +NL+ K+ + L+D G A P Y Sbjct: 147 KAMRELLGSLARLHECGVVHRDVKPANLIAAEKDGGVLKLIDLGAAALCLPLPETLNYYP 206 Query: 214 -----------KEDPKRCHDGTIEFTSIDAHNGVAPSRRG--DLEILGYCMIQWLT 256 ++ G+ T +A + D G M+Q Sbjct: 207 GDGPADPRYAKADELYLLPPGSPRPTKDNAAKLWEAHKPDRFDSWSAGCVMLQLAV 262 >4MWI-A nrPDB Length = 294 Score = 76.4 bits (186), Expect = 2e-14, Method: Composition-based stats. Identities = 34/234 (14%), Positives = 86/234 (36%), Gaps = 20/234 (8%) Query: 97 QKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFG-SDLQKIYEANAKRFSRKTVL 155 ++ +K + + + +G + + ++M+ L+++ + K + + Sbjct: 72 KEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLDRE-KDLTLGKRM 130 Query: 156 QLSLRILDILEYIHEHEY--VHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEY 213 L L L +H E +HG I++SN L+ QV L + L + Sbjct: 131 VLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQG--YQVKLAGFELRKTQTSMSLGTTR 188 Query: 214 KEDPKRCHDGTIEFTSIDAHNGVAP--SRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYV 271 ++ + + S V + ++ G + + TG +P++ + + + Sbjct: 189 EKTDRVKST---AYLSPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGC--NSEKI 243 Query: 272 RDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDILL 325 R + + L + C P E+ + ++ + D + +P + + L Sbjct: 244 RKL-VAVKRQQEPLGEDC------PSELREIIDECRAHDPSVRPSVDEILKKLS 290 >4L68-A nrPDB Length = 340 Score = 76.4 bits (186), Expect = 2e-14, Method: Composition-based stats. Identities = 39/262 (14%), Positives = 92/262 (35%), Gaps = 21/262 (8%) Query: 89 RAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFG-SDLQKIYEANAK 147 + + E + + +L++ + G + ++ F++ L + ++N Sbjct: 76 KLGEREFRYEMNQLWELRHSNLAPLLGFCVVEEEK----FLVYKYMSNGTLHSLLDSNRG 131 Query: 148 RFSRKTVLQLSLRILDILEYIHEHE----YVHGDIKASNLLLNYKNPDQVYLVDYGLAYR 203 T ++ L L ++H H +H +I +S +L++ ++D GLA Sbjct: 132 ELDWSTRFRIGLGAARGLAWLH-HGCRPPILHQNICSSVILIDED--FDARIIDSGLARL 188 Query: 204 YCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLP-WE 262 P ++ G + + + + S +GD+ LG +++ TG Sbjct: 189 MVPSDNNESSFMTGDLGEFG---YVAPEYSTTMLASLKGDVYGLGVVLLELATGLKAVGG 245 Query: 263 DNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKY----METVKLLDYTEKPLYE 318 + K ++ IA D+ K EI+K+ + V +++ Sbjct: 246 EGFKGSLVDWVKQLESSGRIAETFDENIRGKGHDEEISKFVEIALNCVSSRPKERWSMFQ 305 Query: 319 NLRDILLQGLKAIGSKDDGKLD 340 + + + G + D Sbjct: 306 AYQSL-KAIAEKQGYSFSEQDD 326 >2WTK-B nrPDB Length = 373 Score = 76.4 bits (186), Expect = 2e-14, Method: Composition-based stats. Identities = 37/241 (15%), Positives = 82/241 (34%), Gaps = 24/241 (9%) Query: 33 AKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTE-LKFYQRAA 91 +++ IG+G F + ++ + G V V + E + F Q Sbjct: 7 EGGCYELLTVIGKG-FEDLMTVNLARYKPTGE----YVTVRRINLEACSNEMVTFLQGEL 61 Query: 92 KPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFG-SDLQKIYEAN-AKRF 149 ++ + + Y + + D +++ + + + Sbjct: 62 HVSKL--------FNHPNIVPYRATFIADNE----LWVVTSFMAYGSAKDLICTHFMDGM 109 Query: 150 SRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGV 209 + + + +L L+YIH YVH +KAS++L++ +VYL G Sbjct: 110 NELAIAYILQGVLKALDYIHHMGYVHRSVKASHILISVDG--KVYLSGLRSNLSMISHGQ 167 Query: 210 HKEYKEDPKRCHDGTIEFTSIDAH--NGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKD 267 + D + + + S + N + D+ +G + GH+P++D Sbjct: 168 RQRVVHDFPKYSVKVLPWLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPAT 227 Query: 268 P 268 Sbjct: 228 Q 228 >5CLR-A nrPDB Length = 451 Score = 76.1 bits (185), Expect = 3e-14, Method: Composition-based stats. Identities = 42/253 (16%), Positives = 89/253 (35%), Gaps = 27/253 (10%) Query: 70 VKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFM 129 KV D+G + F + + K + + G+ +++ Y Sbjct: 96 FKVYALDDGKTY----FLKSVKIDAESLTEFTNEKDTLSKLGRLVGTFFNEQTQVHYILT 151 Query: 130 IMDRFGSDLQKIYEANAKRFSRK---TVLQLSLRILDILEYIHEHEYVHGDIKASNLLLN 186 G DL + A + K VL + + + ++ HE +H D+K N++L+ Sbjct: 152 TF-IKGIDLSRYKNALPLNVNLKHFWEVLGIMISVCHQVKQFHELGLIHRDLKPGNIMLD 210 Query: 187 YKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDA---HNGVAPSRRGD 243 Q +LVD+G + ++PK GT + + + + +A S+ D Sbjct: 211 AD--MQCHLVDFGSS----------SSDKEPKPASWGTASYLAPELNAQEDFIAFSQVSD 258 Query: 244 LEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYM 303 L L Y + + P+ + K ++ + + ++ C + + Sbjct: 259 LFALAYSLDELFN---PFRQVKFAKVDIGI-KNKHLVLLHAEIEACITGLMSNETSVRTL 314 Query: 304 ETVKLLDYTEKPL 316 ++L P Sbjct: 315 YFSRILQLQRVPE 327 >5VDK-A nrPDB Length = 297 Score = 74.5 bits (181), Expect = 7e-14, Method: Composition-based stats. Identities = 44/244 (18%), Positives = 71/244 (29%), Gaps = 56/244 (22%) Query: 35 KEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKV-EPSDNGPLFTELKFYQRAAKP 93 KE+ IG G FG +Y V + + E S+ E+ + Sbjct: 15 KEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSALHEVYAHAVLGH- 73 Query: 94 EQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYEAN---AKRF 149 + V +Y+ S D + + + G LQ N F Sbjct: 74 -------------HPHVVRYYSSWAEDDH----MIIQNEYCNGGSLQAAISENTKSGNHF 116 Query: 150 SRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQ----------------- 192 + + L+I L YIH VH DIK SN+ + +K + Sbjct: 117 EEPKLKDILLQISLGLNYIHNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLS 176 Query: 193 ----VYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVA-PSRRGDLEIL 247 + D G A V + G F + + + D+ L Sbjct: 177 ANVMYKIGDLGHATSINKPKVEE-----------GDSRFLANEILQEDYRHLPKADIFAL 225 Query: 248 GYCM 251 G + Sbjct: 226 GLTI 229 >5DMZ-A nrPDB Length = 365 Score = 73.7 bits (179), Expect = 1e-13, Method: Composition-based stats. Identities = 48/306 (15%), Positives = 91/306 (29%), Gaps = 48/306 (15%) Query: 39 VGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQK 98 V +G+G F +Y A + V+KV+ N F KP Sbjct: 69 VHHLLGEGAFAQVYEATQGDLNDAKNKQKFVLKVQKPANPWEFYIGTQLMERLKPSMQHM 128 Query: 99 WIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKI---YEANAKRFSRKTVL 155 +++ H S + +G+ L I K + V+ Sbjct: 129 FMKFYSA-------------HLFQNGSVLVGELYSYGTLLNAINLYKNTPEKVMPQGLVI 175 Query: 156 QLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQ---------VYLVDYGLAYRYCP 206 ++R+L ++E +H+ E +HGDIK N +L +Q + L+D G + Sbjct: 176 SFAMRMLYMIEQVHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMKL 235 Query: 207 EGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLK 266 + + T F ++ + + + D + + L G Sbjct: 236 FPKGTIFTAKCE-----TSGFQCVEMLSNKPWNYQIDYFGVAATVYCMLFG--------- 281 Query: 267 DPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMET--VKLLDYTEKPLYENLRDIL 324 Y++ L + + L P + LR L Sbjct: 282 --TYMKVKNEGGECKPEGLFRRLPHLDMWNEFFHVMLNIPDCHHL-----PSLDLLRQKL 334 Query: 325 LQGLKA 330 + + Sbjct: 335 KKVFQQ 340 >5VC6-A nrPDB Length = 289 Score = 73.7 bits (179), Expect = 1e-13, Method: Composition-based stats. Identities = 36/234 (15%), Positives = 58/234 (24%), Gaps = 50/234 (21%) Query: 36 EWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQ 95 E+ IG G FG ++ +K E + Sbjct: 12 EFHELEKIGSGEFGSVFKCVKRLD-----GCIYAIKRSKKPLAGSVDEQNALR------- 59 Query: 96 IQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYEANAK---RFSR 151 LG + + + + G L N + F Sbjct: 60 -----EVYAHAVLGQHSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKE 114 Query: 152 KTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY-----------------KNPDQVY 194 + L L++ L YIH VH DIK SN+ ++ N Sbjct: 115 AELKDLLLQVGRGLRYIHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFK 174 Query: 195 LVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAH-NGVAPSRRGDLEIL 247 + D G R V + G F + + + D+ L Sbjct: 175 IGDLGHVTRISSPQVEE-----------GDSRFLANEVLQENYTHLPKADIFAL 217 >5USZ-A nrPDB Length = 289 Score = 73.0 bits (177), Expect = 2e-13, Method: Composition-based stats. Identities = 43/288 (14%), Positives = 93/288 (32%), Gaps = 40/288 (13%) Query: 43 IGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRT 102 +GQG F I+ G V ++ D F++ A+ Sbjct: 16 LGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASM---------M 66 Query: 103 RKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFG-SDLQKIYEANAKRFSRKTVLQLSLRI 161 KL + + +G + ++ + L + N + L+++ ++ Sbjct: 67 SKLSHKHLVLNYGVCVCGDE----NILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQL 122 Query: 162 LDILEYIHEHEYVHGDIKASNLLL------NYKNPDQVYLVDYGLAYRYCPEGVHKEYKE 215 + ++ E+ +HG++ A N+LL NP + L D G++ P+ + +E Sbjct: 123 AAAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQER-- 180 Query: 216 DPKRCHDGTIEFTSID-AHNGVAPSRRGDLEILGYCMIQWLTGH-LPWEDNLKDPKYVRD 273 I + + N + D G + + +G P K Sbjct: 181 ---------IPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFY 231 Query: 274 SKIRY-----RENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPL 316 +A+L++ C + P + ++ L+ P Sbjct: 232 EDRHQLPAPKAAELANLINNCMDYE--PDHRPSFRAIIRDLNSLFTPD 277 >6J6I-B nrPDB Length = 351 Score = 69.1 bits (167), Expect = 3e-12, Method: Composition-based stats. Identities = 26/200 (13%), Positives = 60/200 (30%), Gaps = 24/200 (12%) Query: 73 EPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKL-----KYLGVPKYWGSGLHDKNGKSYR 127 E D + + K ++++ L + + G L + Sbjct: 78 EIEDRSYMIKRFSEDEITGKRHRVKEVYNDIVLSARMSNHSNFLQLLGCCL----EFPFP 133 Query: 128 FMIMDRFGSDLQK-----IYEANAKRFSRKTVLQLSLRILDILEYIHE---HEYVHGDIK 179 ++ + I L++ I + + Y+H +H D+K Sbjct: 134 VLVFEFAEHGAMNQRGGVIVNGEESLLPWSVRLKIGKEIANAVTYLHTAFPKIIIHRDVK 193 Query: 180 ASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPS 239 ++ L+ ++ + + ++ PEG GT + H + Sbjct: 194 PMHVFLDKNWTAKLSDLSFSIS---LPEGK----SRIEAEWVLGTFGYIDPLYHKTCFVT 246 Query: 240 RRGDLEILGYCMIQWLTGHL 259 D+ G C++ +TG Sbjct: 247 EYTDVYSFGICLLVIITGKP 266 >3REP-A nrPDB Length = 271 Score = 63.0 bits (151), Expect = 2e-10, Method: Composition-based stats. Identities = 26/239 (10%), Positives = 78/239 (32%), Gaps = 28/239 (11%) Query: 97 QKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQ 156 ++ R R + V G+ +GS ++E + ++ Sbjct: 56 EECPRLRIFSHPNVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVK 115 Query: 157 LSLRILDILEYIHEHE-YVHGD-IKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYK 214 +L + + ++H E + + + +++++ ++ + D +++ P ++ Sbjct: 116 FALDMARGMAFLHTLEPLIPRHALNSRSVMIDEDMTARISMADVKFSFQ-SPGRMYA--- 171 Query: 215 EDPKRCHDGTIEFTSIDAHNGVAPS---RRGDLEILGYCMIQWLTGHLPWEDNLKDPKYV 271 + + +A R D+ + + +T +P+ D + Sbjct: 172 ----------PAWVAPEALQKKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEIGM 221 Query: 272 RDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDILLQGLKA 330 + + R I ++K M+ D ++P ++ + IL + Sbjct: 222 KVALEGLRPTIPP---------GISPHVSKLMKICMNEDPAKRPKFDMIVPILEKMQDK 271 >6G4J-A nrPDB Length = 315 Score = 62.6 bits (150), Expect = 3e-10, Method: Composition-based stats. Identities = 38/220 (17%), Positives = 72/220 (32%), Gaps = 34/220 (15%) Query: 34 KKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKP 93 + + +G+G G +YLA+ + +KV D+ + +E+ + +K Sbjct: 25 GNTYTLRKQLGKGANGIVYLAETSDG-------HVALKVS-DDSLSITSEVNVLKSFSKA 76 Query: 94 EQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYEANAKRFSRK 152 + + +P F M+ G L K + Sbjct: 77 QSVTMGPSFFDTDDAYIP---------SANTKVSFYAMEYIKGPLLLKYVSDKGAEW--- 124 Query: 153 TVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKE 212 + L +++L L +H+ ++ GD+K N L+ P ++ +D G + Sbjct: 125 -IPVLMIQLLSSLSVLHQQGWIFGDLKPDN-LIVTGPPARIRCIDVGGTTKEGRAIKEYT 182 Query: 213 YKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMI 252 D GT PS DL + MI Sbjct: 183 EFYDRGYWGYGT---------RKAEPSY--DLFAVAMIMI 211 >5C01-A nrPDB Length = 342 Score = 59.5 bits (142), Expect = 2e-09, Method: Composition-based stats. Identities = 37/286 (12%), Positives = 77/286 (26%), Gaps = 31/286 (10%) Query: 43 IGQGGFGCIYLADMNSSESVGSDAPCVVKVEP----SDNGPLFTELKFYQRAAKPEQIQK 98 +GQG +Y + S + + +P D G + + + Sbjct: 66 LGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALA 125 Query: 99 WIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSD-LQKIYEANAKRFSRKTVLQL 157 + T L + M+ + L + + Sbjct: 126 FYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVV 185 Query: 158 SLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQ-----VYLVDYGLAYRYCPEGVHKE 212 + ++ L Y+ VHG++ N+LL + + L D G+ E Sbjct: 186 AQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVE 245 Query: 213 YKEDPKRCHDGTIEFTSIDAHNGVAPSRRG--DLEILGYCMIQWLT-GHLPWEDNLKDPK 269 I + + + G A S D G +++ G P + K Sbjct: 246 R-----------IPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEK 294 Query: 270 YVRDSKIRYRENIAS-----LMDKCFPEKNKPGEIAKYMETVKLLD 310 + + L +C + P + + ++ L Sbjct: 295 EHFYQRQHRLPEPSCPQLATLTSQCLTYE--PTQRPSFRTILRDLT 338 >4WOV-A nrPDB Length = 317 Score = 59.5 bits (142), Expect = 2e-09, Method: Composition-based stats. Identities = 37/286 (12%), Positives = 77/286 (26%), Gaps = 31/286 (10%) Query: 43 IGQGGFGCIYLADMNSSESVGSDAPCVVKVEP----SDNGPLFTELKFYQRAAKPEQIQK 98 +GQG +Y + S + + +P D G + + + Sbjct: 43 LGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALA 102 Query: 99 WIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSD-LQKIYEANAKRFSRKTVLQL 157 + T L + M+ + L + + Sbjct: 103 FYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVV 162 Query: 158 SLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQ-----VYLVDYGLAYRYCPEGVHKE 212 + ++ L Y+ VHG++ N+LL + + L D G+ E Sbjct: 163 AQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVE 222 Query: 213 YKEDPKRCHDGTIEFTSIDAHNGVAPSRRG--DLEILGYCMIQWLT-GHLPWEDNLKDPK 269 I + + + G A S D G +++ G P + K Sbjct: 223 R-----------IPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEK 271 Query: 270 YVRDSKIRYRENIAS-----LMDKCFPEKNKPGEIAKYMETVKLLD 310 + + L +C + P + + ++ L Sbjct: 272 EHFYQRQHRLPEPSCPQLATLTSQCLTYE--PTQRPSFRTILRDLT 315 >4CI6-B nrPDB Length = 643 Score = 59.5 bits (142), Expect = 3e-09, Method: Composition-based stats. Identities = 45/283 (15%), Positives = 101/283 (35%), Gaps = 40/283 (14%) Query: 55 DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAK---PEQIQKWIRTRKLKYLGVP 111 + ++ + +E D L +++ + K I K+ + Sbjct: 46 RVAETDKFAEGESHISIIETKDKQRLVAKIERSIAEGHLFAELEAYKHIYKTAGKHPNLA 105 Query: 112 KYWGSGLHDKNGKSYRFMIMDRFGS-----DLQKIYEA--NAKRFSRK---TVLQLSLRI 161 G + + Y ++MD L+ + ++ K S T+ ++ R+ Sbjct: 106 NVHGMAVVPYGNRYYYALLMDEVDGWRCSDTLRSLADSWKQGKINSEAYWGTIKFIAHRL 165 Query: 162 LDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCH 221 LD+ ++ + VH DIK N++ + + + V ++D GL R ++ Sbjct: 166 LDVTNHLAKAGIVHNDIKPGNVVFDRASGEPV-VIDLGLHSR------------SGEQPK 212 Query: 222 DGTIEFTSIDAHNG-VAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRY-R 279 T F + + G + S + D+ + L G E KDP+ + +R+ Sbjct: 213 GFTESFKAPELGVGNLGASEKSDVF---LVVSTLLHGI---EGFEKDPEIKPNQGLRFIT 266 Query: 280 ENIASLMDKCFPEKNKP------GEIAKYMETVKLLDYTEKPL 316 A +MD+ ++P +++ + + +P Sbjct: 267 SEPAHVMDENGYPIHRPGIAGVETAYTRFITDILGVSADSRPD 309 >4I94-A nrPDB Length = 300 Score = 50.6 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 22/178 (12%), Positives = 58/178 (32%), Gaps = 15/178 (8%) Query: 84 LKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGS-GLHDKNGKSYRFMIMDRFGSDLQKIY 142 +K + R + P+ Q + + L + G ++ + + + ++ Sbjct: 58 VKRFNRKSWPDSRQFLEEAKAVGQLRNHRMANLLGCCYEDEERLLIAEFMPNETLAKHLF 117 Query: 143 EANAKRFSRKTVLQLSLRILDILEYIHEHE-YVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 ++ L+++L I LEY ++ D+ A +L + ++ +GL Sbjct: 118 HWESQPMKWAMRLRVALHIAQALEYCTSKGRALYHDLNAYRVLFDDDANPRLSC--FGLM 175 Query: 202 YRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHL 259 + + + FT + + + G ++ L+G Sbjct: 176 K-----------NSRDGKSYSTNLAFTPPEYLRTGRVTPESVIYSFGTLLLDLLSGKH 222 >3ENH-A nrPDB Length = 540 Score = 50.6 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 34/190 (17%), Positives = 72/190 (37%), Gaps = 26/190 (13%) Query: 18 HLAEQFAVGEIITDMAKKEWKV-----GLPIGQGGFGCIYLADMNSSESVGSDAPCVVKV 72 L E + TDM + W I + G AD+ + D +V Sbjct: 309 SLDETKIIPNYRTDMVEVNWIKEIKGKKRKIPEHLIGKGAEADIKRDSYLDFDVIIKERV 368 Query: 73 EPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMD 132 + + + + + K ++ +K G+P + D + + R M+ Sbjct: 369 KKG-----YRDERLDENIRKSRTAREARYLALVKDFGIPA---PYIFDVDLDNKRIMMSY 420 Query: 133 RFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQ 192 G + + E N L ++ +I +I+ +H+++ +H D+ SN + + Sbjct: 421 INGKLAKDVIEDN---------LDIAYKIGEIVGKLHKNDVIHNDLTTSNFIFDKD---- 467 Query: 193 VYLVDYGLAY 202 +Y++D+GL Sbjct: 468 LYIIDFGLGK 477 >6EWX-A nrPDB Length = 484 Score = 50.2 bits (118), Expect = 1e-06, Method: Composition-based stats. Identities = 26/192 (13%), Positives = 56/192 (29%), Gaps = 53/192 (27%) Query: 143 EANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLL----------------- 185 + V L L++ + LE++ EH +H D+ NLLL Sbjct: 201 HRAEPEVYERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLVHCNPQSSPGPSANPSV 260 Query: 186 ----------------------NYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDG 223 K+ ++ + ++ A + + + K+ R Sbjct: 261 PTTTSRCPSAAPAATTACQGGPGEKHLPRLIISNFLKAKQKPGGTTNLQQKKSQAR---- 316 Query: 224 TIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRYRENIA 283 + + + + R+ D G + + L P+E + + RE++ Sbjct: 317 ----LAPEIVS-ASQYRKFDEFQTGILIYELLHQPNPFE-----VRAQLRERDYRREDLP 366 Query: 284 SLMDKCFPEKNK 295 L Sbjct: 367 PLPTLSLYSPGL 378 >4OAU-C nrPDB Length = 699 Score = 48.7 bits (114), Expect = 4e-06, Method: Composition-based stats. Identities = 45/269 (16%), Positives = 88/269 (32%), Gaps = 71/269 (26%) Query: 109 GVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRIL----DI 164 + ++GS H + + F+ + L+ + + + + +L Sbjct: 396 HLVTFYGSESH----RGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKA 451 Query: 165 LEYIH-EHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDG 223 ++ +H Y H D++ N+L++ K +L D+ D Sbjct: 452 VQELHLSCGYTHQDLQPQNILIDSKK--AAHLADF-----------------------DK 486 Query: 224 TIEFTSIDAHNGVAPSRRGDLEILG-YCMIQWLTGHLPWEDNLKDPKYVRDSKIRYRENI 282 +I++ G + DLE LG + G + +ED LK ++ E Sbjct: 487 SIKWA------GDPQEVKRDLEDLGRLVLYVVKKGSISFED-LKAQSNEEVVQLSPDEET 539 Query: 283 ASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDILLQGLKAIGSKDDGKLD-- 340 L+ + F E++RD L L G + Sbjct: 540 KDLIHRLFHPG------------------------EHVRDCLSDLL---GHPFFWTWESR 572 Query: 341 LSVVENGGLKAKTITKKRKKEIEESKEPG 369 + N G ++ T+K + EI +PG Sbjct: 573 YRTLRNVGNESDIKTRKSESEILRLLQPG 601 >3BYV-A nrPDB Length = 377 Score = 48.7 bits (114), Expect = 4e-06, Method: Composition-based stats. Identities = 55/312 (17%), Positives = 102/312 (32%), Gaps = 36/312 (11%) Query: 39 VGLPIG-QGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQ 97 G +G + + + D + ES P + PS+ E R + + Q Sbjct: 77 RGTVLGQEDPYAYLEATDQETGESFEVHVPYFTERPPSNAIKQMKEEVLRLRLLRGIKNQ 136 Query: 98 KWIRTRK--------LKYLGVPKYWGSGLHDKNGKSY-RFMIMDRFGSDLQKI------Y 142 K + +K K L +++ RF + R S+LQ + Sbjct: 137 KQAKVHLRFIFPFDLVKDPQKKKMIRVRLDERDMWVLSRFFLYPRMQSNLQTFGEVLLSH 196 Query: 143 EANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAY 202 + K LQL+L+++ +L +H + VH ++ +++L+ + V+L + Sbjct: 197 SSTHKSLVHHARLQLTLQVIRLLASLHHYGLVHTYLRPVDIVLDQRGG--VFLTGFEHLV 254 Query: 203 RY---CPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHL 259 R V + ++ TI + + D LG + L Sbjct: 255 RDGARVVSSVSRGFEPPELEARRATISY---HRDRRTLMTFSFDAWALGLVIYWIWCADL 311 Query: 260 PWEDNLKDPKYVRDSKIRYR---ENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPL 316 P + + S+ +R + P E + + L E P Sbjct: 312 P----ITKDAALGGSEWIFRSCKNIPQPVRALLEGFLRYPKE-----DRLLPLQAMETPE 362 Query: 317 YENLRDILLQGL 328 YE LR L L Sbjct: 363 YEQLRTELSAAL 374 >3DZO-A nrPDB Length = 413 Score = 48.3 bits (113), Expect = 6e-06, Method: Composition-based stats. Identities = 55/309 (17%), Positives = 99/309 (32%), Gaps = 31/309 (10%) Query: 39 VGLPIG-QGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQ 97 G +G + + + D + ES P + PS+ E R + + Q Sbjct: 82 RGTVLGQEDPYAYLEATDQETGESFEVHVPYFTERPPSNAIKQMKEEVLRLRLLRGIKNQ 141 Query: 98 KWIRTRK--------LKYLGVPKYWGSGLHDKNGKSY-RFMIMDRFGSDLQKI------Y 142 K + +K K L +++ RF + R S+LQ + Sbjct: 142 KQAKVHLRFIFPFDLVKDPQKKKMIRVRLDERDMWVLSRFFLYPRMQSNLQTFGEVLLSH 201 Query: 143 EANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAY 202 + K LQL+L+++ +L +H + VH ++ +++L+ + V+L + Sbjct: 202 SSTHKSLVHHARLQLTLQVIRLLASLHHYGLVHTYLRPVDIVLDQRGG--VFLTGFEHLV 259 Query: 203 RYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWE 262 R V H+ + D LG + LP Sbjct: 260 RDGASAV-SPIGRGFAPPETTAERMLPFGQHHPTLMTFAFDTWTLGLAIYWIWCADLPNT 318 Query: 263 DNLKDPKYVRDSKIRYR---ENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYEN 319 D+ + S+ +R + P E + + L E P YE Sbjct: 319 DDAA----LGGSEWIFRSCKNIPQPVRALLEGFLRYPKE-----DRLLPLQAMETPEYEQ 369 Query: 320 LRDILLQGL 328 LR L L Sbjct: 370 LRTELSAAL 378 >5VE6-A nrPDB Length = 492 Score = 47.2 bits (110), Expect = 1e-05, Method: Composition-based stats. Identities = 13/35 (37%), Positives = 21/35 (60%) Query: 151 RKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLL 185 + V L L++ + LE++ EH +H D+ NLLL Sbjct: 207 ERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLL 241 >6BHC-A nrPDB Length = 438 Score = 46.4 bits (108), Expect = 2e-05, Method: Composition-based stats. Identities = 37/242 (15%), Positives = 79/242 (32%), Gaps = 24/242 (9%) Query: 51 IYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGV 110 +Y + + + + A + K + ++ + L Q A IQ+ + Sbjct: 72 VYYTASYAKDPLNNYAVKICKSKAKESQQYYHSLAVRQSLAVHFNIQQDCGHFLAEVPNR 131 Query: 111 PKYWGSGLHDKNGKSYRFM-------IMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILD 163 W + + D L + + + V L L++ Sbjct: 132 LLPWEDPSKKQRSHVVVITREVPCLTVADFVRDSLAQ--HGKSPDLYERQVCLLLLQLCS 189 Query: 164 ILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA-----YRYCPEGVHKEYKEDPK 218 LE++ + H D++ NLLL + P +G A Y + + + + Sbjct: 190 GLEHLKPYHVTHCDLRLENLLLVHYQPGG-TAQGFGPAEPTPTSSYPTRLIVSNFSQAKQ 248 Query: 219 RCHDGTIEF------TSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDN--LKDPKY 270 + H E + + ++ D G + + L P+++N LK+ +Y Sbjct: 249 KSHLVDPEILRDQSRLAPEIIT-ATQYKKCDEFQTGILIYEMLHLPNPFDENPELKEREY 307 Query: 271 VR 272 R Sbjct: 308 TR 309 >2W1Z-A nrPDB Length = 368 Score = 46.4 bits (108), Expect = 2e-05, Method: Composition-based stats. Identities = 53/301 (17%), Positives = 96/301 (31%), Gaps = 30/301 (9%) Query: 46 GGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRK- 104 G + C+ D + E + P + PS+ +E R + + Q+ + Sbjct: 70 GSYICLEATDQETGEPLEVHVPYFTERPPSNAIKQLSEQVLRLRLLRGIKNQRQAKAYLR 129 Query: 105 -------LKYLGVPKYWGSGLHDKNGKSY-RFMIMDRFGSDLQKI------YEANAKRFS 150 +K K L +++ RF + R S+L + + + K Sbjct: 130 FIFPIDLVKDPKKRKMIRVRLDERDMWVLSRFFLYPRMQSNLHILGDVLLSHSSTHKSLV 189 Query: 151 RKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVH 210 LQL+L+++ + + + VH D + N+LL+ + + G + Sbjct: 190 HHARLQLTLQLIRLAASLQHYGLVHADFQVRNILLDQRGGVFLT----GFEHLVRDGASA 245 Query: 211 KEYKEDPKRCHDGTIEFTSID-AHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPK 269 + T E H+ + D LG + LP N +D + Sbjct: 246 VSPIGRGFAPPETTAERMLPYRQHHPTLMTFPFDTWTLGLAIYWIWCADLP---NTEDAE 302 Query: 270 YVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYT--EKPLYENLRDILLQG 327 I R P + +Y + +LL E YE LR L Sbjct: 303 LGGIEWIYRRCKNIP-----QPVRALLEGFLRYSKEDRLLPLQAMETSEYEQLRTELSAV 357 Query: 328 L 328 L Sbjct: 358 L 358 >4AZW-A nrPDB Length = 471 Score = 45.2 bits (105), Expect = 5e-05, Method: Composition-based stats. Identities = 22/145 (15%), Positives = 49/145 (33%), Gaps = 11/145 (7%) Query: 56 MNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWG 115 S V K D + QR + T+ P Sbjct: 250 HKRSRRYFFGEDYVCKFFYYDMPHGILTAEESQRNKHELHNEIKFLTQPPAGFDAPAVLA 309 Query: 116 SGLHDKNGKSYRFMIMDRF-GSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYV 174 G + ++G +++M++ G L + A ++ +L L + + + Sbjct: 310 HGENAQSG----WLVMEKLPGRLLSDMLAAGE----EIDREKILGSLLRSLAALEKKGFW 361 Query: 175 HGDIKASNLLLNYKNPDQVYLVDYG 199 H D++ N++++ + L+D+G Sbjct: 362 HDDVRPWNVMVDAR--QHARLIDFG 384 >4O1O-A nrPDB Length = 717 Score = 45.2 bits (105), Expect = 5e-05, Method: Composition-based stats. Identities = 31/196 (15%), Positives = 65/196 (33%), Gaps = 41/196 (20%) Query: 109 GVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQK-IYEANAKRFSRKT---VLQLSLRILDI 164 V ++GS ++ S + + LQ+ + + + + Sbjct: 399 NVVTFYGS----ESDGSCLHVCLALCEYTLQEHLANHRGDAVPNEEDESARNILSSLFKA 454 Query: 165 LEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGT 224 + +H Y H D++ N+L++ KN +L D+ ++ EDP++ Sbjct: 455 IGELHRSGYSHQDLQPQNILIDSKNGT--FLADF---------DKSIKWAEDPQK----- 498 Query: 225 IEFTSIDAHNGVAPSRRGDLEILG-YCMIQWLTGHLPWEDNLKDPKYVRDSKIRYRENIA 283 + DLE LG + G + +E LK+ + + E Sbjct: 499 ---------------IKRDLEALGLLVLYVVKKGDISFET-LKNQSFEEVIQGSPDEETR 542 Query: 284 SLMDKCFPEKNKPGEI 299 L+ F + + Sbjct: 543 DLIHHLFHPGDNVEDR 558 >4AZV-A nrPDB Length = 569 Score = 42.9 bits (99), Expect = 2e-04, Method: Composition-based stats. Identities = 12/73 (16%), Positives = 33/73 (45%), Gaps = 7/73 (9%) Query: 128 FMIMDRF-GSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLN 186 +++M++ G L + A ++ +L L + + + H D++ N++++ Sbjct: 318 WLVMEKLPGRLLSDMLAAGE----EIDREKILGSLLRSLAALEKQGFWHDDVRPWNVMVD 373 Query: 187 YKNPDQVYLVDYG 199 + L+D+G Sbjct: 374 AR--QHARLIDFG 384 >4WWA-A nrPDB Length = 261 Score = 41.0 bits (94), Expect = 9e-04, Method: Composition-based stats. Identities = 28/172 (16%), Positives = 62/172 (36%), Gaps = 20/172 (11%) Query: 42 PIGQGGFGCIYLAD--MNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKW 99 PI QG ++ + S ++K P + + + + Sbjct: 21 PISQGAEAIVFTTTTHPYLPRAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNESRLL 80 Query: 100 IRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDL----------QKIYEANAKRF 149 + + L VP+ ++ F+ ++ G DL ++ + + Sbjct: 81 AKLYLIPGLCVPQLIACDPYNG------FIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPY 134 Query: 150 SRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPD-QVYLVDYGL 200 S V ++ + +H ++Y HGD+ +SN++L +L+D+GL Sbjct: 135 S-DLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGL 185 >6M7Z-A nrPDB Length = 319 Score = 38.7 bits (88), Expect = 0.004, Method: Composition-based stats. Identities = 32/304 (10%), Positives = 88/304 (28%), Gaps = 39/304 (12%) Query: 27 EIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEP-SDNGPLFTELK 85 + + D+ + + + G F + + + ++ + P + +++ Sbjct: 22 KELPDIDESRNPILKRLLSGSFLRRDGSTTVNVRVPARELVRLLSLTPEQQREGVSAKVR 81 Query: 86 FYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEAN 145 + + R++ L + G ++ + + E Sbjct: 82 LINLLDPKYSVYEPYLYREI-LPKRSPLLLPSLGEYRGAFLTYIFHPLSKGLVGDMLETG 140 Query: 146 AKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYC 205 S V L+ ++ L+ +H +H I+ ++ + + +D Sbjct: 141 R---SHPDVQVLAANMVAALKSLHNLGLLHRSIELNSFSVLPDGTVVLGGLD-------- 189 Query: 206 PEGVHKEYKEDPKRCHDGTIEFTSIDAHNG---------VAPSRRGDLEILGYCM--IQW 254 + + + T+ + + + D+ LG + Sbjct: 190 ---TAAPIGTETRLWVGFFGQETAPEIDRNFLADLALTQGRHTVKSDVYSLGVAFRNLVQ 246 Query: 255 LTGHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVK-----LL 309 L G + P+ + + E + L K E+ PG E +K L Sbjct: 247 LLG-----NGNLGPEDRGAVRQDHLELLDKLSQKMIEEE--PGNRPTIEEIMKDPLFEGL 299 Query: 310 DYTE 313 ++ + Sbjct: 300 NFED 303 >6EAS-A nrPDB Length = 308 Score = 38.3 bits (87), Expect = 0.006, Method: Composition-based stats. Identities = 34/220 (15%), Positives = 75/220 (34%), Gaps = 35/220 (15%) Query: 43 IGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRT 102 IG +Y ++S + L T K + + + + +K Sbjct: 48 IGSTSTCMLYKGTLSSGVEIAV------------ASSLVTSAKDWSKENESQYRKKITNL 95 Query: 103 RKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF--GSDLQKIYEANAKRFSRKTVLQLSLR 160 K+ + G ++ R M+ + G+ + ++ A++ L++S+ Sbjct: 96 SKVSHKNFMNLLGY--CEEEHPFTRVMVFEYAPNGTLFEHLHVREAEKLDWMARLRISMG 153 Query: 161 ILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRC 220 I LE++H+ + + L + VYL D A + + + Sbjct: 154 IAYCLEHMHQLQ------TPA--ALRNFDSTTVYLTD-DFAAKVSDLEF-----WNDAKG 199 Query: 221 HDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLP 260 H+ T + +P + G +++ LTG +P Sbjct: 200 HNST-----TNNELAFSPDMEDIVRKYGMVLLEILTGRVP 234 >6FAI-l nrPDB Length = 425 Score = 37.5 bits (85), Expect = 0.009, Method: Composition-based stats. Identities = 26/172 (15%), Positives = 57/172 (33%), Gaps = 22/172 (12%) Query: 37 WKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQI 96 + VG IG G IY + P V+K+ + K Q Sbjct: 95 YSVGNTIGVGKESDIYKVSDKNG------NPRVMKIHRLGRTSFHSVRNNRDYLKKSNQG 148 Query: 97 QKWIRTRKL----KYLGVPKYW--GSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFS 150 W+ +L +Y + + G + + S ++M+ + + Sbjct: 149 ANWMHLSRLAANKEYQFMSMLYSKGFKVPEPFDNSRHIVVMELIEGYPMRRLRKH----- 203 Query: 151 RKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQ----VYLVDY 198 K + +L ++ + + +H D N+++ K D+ ++D+ Sbjct: 204 -KNIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDF 254 >4CYJ-A nrPDB Length = 438 Score = 37.5 bits (85), Expect = 0.010, Method: Composition-based stats. Identities = 16/149 (10%), Positives = 49/149 (32%), Gaps = 16/149 (10%) Query: 94 EQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRF-------MIMDRFGSDLQKIYEANA 146 ++ W + + + + + + + + + + + + + Sbjct: 101 NVMKDWKKIKNASIVTIHEVFTTREFGDSSLIFAYDFHPLSKTLQEHHFQPIHGNRYRPP 160 Query: 147 KRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNP---DQVYLVD---YGL 200 T+ +I + L+ IH + ++ S ++L N ++D +G+ Sbjct: 161 PAVPENTIWGYICQIANALKTIHSNRLAARCLEPSKIILTDINRIRLSACAILDVVQFGM 220 Query: 201 AYRYCPEGVHKEYKEDPKRCH---DGTIE 226 R E +++ + K GT+ Sbjct: 221 NSRSVVELQQEDFVKFGKLILSLATGTLP 249 >6FDN-A nrPDB Length = 320 Score = 37.1 bits (84), Expect = 0.014, Method: Composition-based stats. Identities = 20/164 (12%), Positives = 55/164 (33%), Gaps = 15/164 (9%) Query: 38 KVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQ 97 VG +G G IY+ + ++ + L + +++ + Sbjct: 96 SVGNQMGVGKESDIYIVANEEGQQFALKLH---RLGRTSFRNLKNKRDYHKHRHNVSWLY 152 Query: 98 KWIRTRKLKYLGVPKYWGSGLHDKNGKSYR--FMIMDRFGSD-LQKIYEANAKRFSRKTV 154 + ++ + + Y ++M+ L +I+ Sbjct: 153 LSRLSAMKEFAYMKALYERKFPVPKPIDYNRHAVVMELINGYPLCQIHHVEDPASVYDEA 212 Query: 155 LQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDY 198 ++L +++ + H +HGD NL+L+ + + ++D+ Sbjct: 213 MELIVKLAN-------HGLIHGDFNEFNLILDESD--HITMIDF 247 >6G18-v nrPDB Length = 552 Score = 36.8 bits (83), Expect = 0.016, Method: Composition-based stats. Identities = 20/164 (12%), Positives = 55/164 (33%), Gaps = 15/164 (9%) Query: 38 KVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQ 97 VG +G G IY+ + ++ + L + +++ + Sbjct: 96 SVGNQMGVGKESDIYIVANEEGQQFALKLH---RLGRTSFRNLKNKRDYHKHRHNVSWLY 152 Query: 98 KWIRTRKLKYLGVPKYWGSGLHDKNGKSYR--FMIMDRFGSD-LQKIYEANAKRFSRKTV 154 + ++ + + Y ++M+ L +I+ Sbjct: 153 LSRLSAMKEFAYMKALYERKFPVPKPIDYNRHAVVMELINGYPLCQIHHVEDPASVYDEA 212 Query: 155 LQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDY 198 ++L +++ + H +HGD NL+L+ + + ++D+ Sbjct: 213 MELIVKLAN-------HGLIHGDFNEFNLILDESD--HITMIDF 247 >1TQM-A nrPDB Length = 282 Score = 36.4 bits (82), Expect = 0.022, Method: Composition-based stats. Identities = 32/186 (17%), Positives = 71/186 (38%), Gaps = 29/186 (15%) Query: 39 VGLPIGQGGFGCIYLADMNSSESVGSDAPCV------VKVEPSDNGPLFTELKFYQRAAK 92 +G +G+G ++ V E D G L + + A Sbjct: 94 IGKLMGEGKESAVFNCYSEKFGECVVKFHKVGHTSFKKVKEKRDYGDLHFSVLAIRSAR- 152 Query: 93 PEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRK 152 ++ +KL+ L VPK + ++M+ D +++Y + + Sbjct: 153 ----NEFRALQKLQGLAVPKVY--------AWEGNAVLMELI--DAKELYRV--RVENPD 196 Query: 153 TVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKE 212 VL + L ++ ++ H VHGD+ N+L++ + ++++D+ + EG + Sbjct: 197 EVLDMILE--EVAKFYH-RGIVHGDLSQYNVLVSEEG---IWIIDFPQSVEVGEEGWREI 250 Query: 213 YKEDPK 218 + D + Sbjct: 251 LERDVR 256 >4BVU-A nrPDB Length = 211 Score = 36.0 bits (81), Expect = 0.032, Method: Composition-based stats. Identities = 17/108 (15%), Positives = 38/108 (35%), Gaps = 7/108 (6%) Query: 116 SGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRI----LDILEYIHEH 171 S L + +++ G ++ S + I L ++ ++E Sbjct: 88 SELFNAFYGDEASVVIQYGGDVYLRMLRVPGTPLSDIDTADIPDNIESLYLQLICKLNEL 147 Query: 172 EYVHGDIKASNLLLNYKNPDQVYLVDYG--LAYRYCPEGVHKEYKEDP 217 +H D+ N+L + K + ++ +D+ A Y KE + Sbjct: 148 SIIHYDLNTGNMLYD-KESESLFPIDFRNIYAEYYAATKKDKEIIDRR 194 >2DLC-X nrPDB Length = 394 Score = 35.2 bits (79), Expect = 0.046, Method: Composition-based stats. Identities = 23/129 (17%), Positives = 44/129 (34%), Gaps = 13/129 (10%) Query: 198 YGLAYRYCPEGVHKEY-------KEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYC 250 +GL + E ++ + ++ + + GT V ++ D G Sbjct: 13 FGLITKNLQEVLNPQIIKDVLEVQKRHLKLYWGTAPTGRPHCGYFVPMTKLADFLKAGCE 72 Query: 251 MIQWLTGHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLD 310 + L + DN+K P V + + +Y E + + N P E ++ V Sbjct: 73 VTVLLADLHAFLDNMKAPLEVVNYRAKYYELTIKAILR---SINVPIEK---LKFVVGSS 126 Query: 311 YTEKPLYEN 319 Y P Y Sbjct: 127 YQLTPDYTM 135 >3I4T-A nrPDB Length = 292 Score = 35.2 bits (79), Expect = 0.048, Method: Composition-based stats. Identities = 19/97 (19%), Positives = 34/97 (35%), Gaps = 5/97 (5%) Query: 261 WEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENL 320 W ++ + Y KI N+ +L+ K + E +K D E P Y + Sbjct: 157 WSEHWRPSSYYPKIKINRDNNMHTLVLLDIKVKERSEE-----SIIKGRDIFEPPRYMTI 211 Query: 321 RDILLQGLKAIGSKDDGKLDLSVVENGGLKAKTITKK 357 + Q L+ + G D + G + +K Sbjct: 212 NQCIEQLLEVEKEQHLGVYDEDTMVVGMARVACADQK 248 >4Q93-A nrPDB Length = 372 Score = 34.8 bits (78), Expect = 0.071, Method: Composition-based stats. Identities = 24/140 (17%), Positives = 49/140 (35%), Gaps = 12/140 (8%) Query: 190 PDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGY 249 ++++L+ L E + + KE + + GT V S+ D G Sbjct: 8 EEKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHVAYFVPMSKIADFLKAGC 67 Query: 250 CMIQWLTGHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLL 309 + + DN+K P + + ++ Y EN+ M + P E L Sbjct: 68 EVTILFADLHAYLDNMKAPWELLELRVSYYENVIKAMLE---SIGVPLE---------KL 115 Query: 310 DYTEKPLYENLRDILLQGLK 329 + + Y+ ++ L + Sbjct: 116 KFIKGTDYQLSKEYTLDVYR 135 >6EF6-A nrPDB Length = 354 Score = 34.1 bits (76), Expect = 0.098, Method: Composition-based stats. Identities = 11/52 (21%), Positives = 25/52 (48%), Gaps = 4/52 (7%) Query: 172 EYVHGDIKASNLLLNYKNPDQ-VYLVDY---GLAYRYCPEGVHKEYKEDPKR 219 +H D++ +NLL++ P + + ++D+ G + + G + E R Sbjct: 226 GLIHADLRLANLLVDSSTPQRTITVIDFDDCGFGWYFYDFGTAVSFIEHDPR 277 >2H2W-A nrPDB Length = 312 Score = 32.5 bits (72), Expect = 0.30, Method: Composition-based stats. Identities = 22/137 (16%), Positives = 45/137 (32%), Gaps = 14/137 (10%) Query: 163 DILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHD 222 + + + E +H DI+ +L+ PD++ + L + H Sbjct: 30 EGIFVMTEKRAIHQDIRPLEILILNLMPDKIK-TEIQLLRLLGNTPLQVNVTLLYTETHK 88 Query: 223 GTIEFTSIDAHNG------VAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKI 276 + T I+ R+ D G+ + LP+E+ + + Sbjct: 89 --PKHTPIEHILKFYTTFSAVKDRKFD----GFIITGAPVELLPFEEVDYWEELTEIMEW 142 Query: 277 RYRENIASLMDKCFPEK 293 R N+ S M C+ + Sbjct: 143 S-RHNVYSTMFICWAAQ 158 >4GYG-A nrPDB Length = 397 Score = 32.5 bits (72), Expect = 0.34, Method: Composition-based stats. Identities = 19/179 (10%), Positives = 57/179 (31%), Gaps = 15/179 (8%) Query: 28 IITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFY 87 K + VG IG G I + + + ++ + Sbjct: 88 HTHAARKDVYSVGSRIGVGKESDIMIVADEKGKQKVLKIHRLGRIS-FRTVKANRDYLRN 146 Query: 88 QRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAK 147 + + + ++ ++ G + + +S ++M + + + Sbjct: 147 RSTGSWMYLSRLAAIKEFAFMKALYEEGFPVPEPIAQSRHTIVMSLVDALPMRQVSSVPD 206 Query: 148 RFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLL----NYKNPDQVY----LVDY 198 L ++ ++ + +H +HGD N+L+ + ++P + ++D+ Sbjct: 207 P------ASLYADLIALILRLAKHGLIHGDFNEFNILIREEKDAEDPSSITLTPIIIDF 259 >5YK0-A nrPDB Length = 452 Score = 32.1 bits (71), Expect = 0.42, Method: Composition-based stats. Identities = 15/129 (11%), Positives = 37/129 (28%), Gaps = 30/129 (23%) Query: 71 KVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMI 130 ++E ++ + R P + + +++ H + Sbjct: 213 RLEAANQRAFAKAYHDHPRFQVPHVVASAPKVVIQEWIEGVPMAEIIRHGTTEQR----- 267 Query: 131 MDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNP 190 D G+ L ++ +R +HGD N +L Sbjct: 268 -DLIGTLLAELTFDAPRRL----------------------GLMHGDAHPGNFMLLPDG- 303 Query: 191 DQVYLVDYG 199 ++ ++D+G Sbjct: 304 -RMGIIDFG 311 >3Q60-A nrPDB Length = 371 Score = 32.1 bits (71), Expect = 0.45, Method: Composition-based stats. Identities = 30/226 (13%), Positives = 72/226 (31%), Gaps = 31/226 (13%) Query: 120 DKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRK------TVLQLSLRILDILEYIHEHEY 173 D + ++M DL+ ++ + + + L+ +++ + + Sbjct: 156 DDYAVANYLLLMPAASVDLELLFSTLDFVYVFRGDEGILALHILTAQLIRLAANLQSKGL 215 Query: 174 VHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAH 233 VHG NL + ++ L D + K P + + + Sbjct: 216 VHGHFTPDNLFIMPDG--RLMLGD--------VSALWKVGTRGPASSV--PVTYAPREFL 263 Query: 234 NGVAPSRRGDL--EILGYCMIQWLTGHLPW---EDNLKDPKYVRDSKIRYRENIASLMDK 288 N + L LG + + LP+ +K ++ +++A Sbjct: 264 NASTATFTHALNAWQLGLSIYRVWCLFLPFGLVTPGIKGSWKRPSLRVPGTDSLA--FGS 321 Query: 289 CFPEKNKPGE-IAKYMETVKL-----LDYTEKPLYENLRDILLQGL 328 C P + I +++ + L+ E P + L++ + L Sbjct: 322 CTPLPDFVKTLIGRFLNFDRRRRLLPLEAMETPEFLQLQNEISSSL 367 >4H05-A nrPDB Length = 273 Score = 31.8 bits (70), Expect = 0.50, Method: Composition-based stats. Identities = 9/27 (33%), Positives = 15/27 (55%) Query: 173 YVHGDIKASNLLLNYKNPDQVYLVDYG 199 HGD+ N+LL+ + + L+D G Sbjct: 186 VCHGDLCPDNVLLDPRTCEVTGLIDVG 212 >6G38-A nrPDB Length = 357 Score = 31.8 bits (70), Expect = 0.52, Method: Composition-based stats. Identities = 27/203 (13%), Positives = 58/203 (28%), Gaps = 47/203 (23%) Query: 18 HLAEQFAVGEIITDMAKKEWKVGL--PIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPS 75 + E G + K+ IG+G FG ++ +++ P +K+ Sbjct: 22 SMGECSQKGPVPFSHCLPTEKLQRCEKIGEGVFGEVF-------QTIADHTPVAIKIIAI 74 Query: 76 DNGPLFT--ELKFYQRAAKPEQIQKWIRTRKLKYLG----------VPKYWGSGL----- 118 + L K ++ I K + + V GS Sbjct: 75 EGPDLVNGSHQKTFEEILPEIIISKELSLLSGEVCNRTEGFIGLNSVHCVQGSYPPLLLK 134 Query: 119 -----------------HDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRI 161 K+ + + + + G DL+++ + S T + ++ Sbjct: 135 AWDHYNSTKGSANDRPDFFKDDQLFIVLEFEFGGIDLEQMRTKLS---SLATAKSILHQL 191 Query: 162 LDILEYIH-EHEYVHGDIKASNL 183 L + H D+ N+ Sbjct: 192 TASLAVAEASLRFEHRDLHWGNV 214 >6DFL-A nrPDB Length = 259 Score = 30.6 bits (67), Expect = 1.2, Method: Composition-based stats. Identities = 25/161 (15%), Positives = 50/161 (31%), Gaps = 10/161 (6%) Query: 49 GCIY--LADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLK 106 G +Y L + + VK+ + + Q+W R+L Sbjct: 27 GKVYRELEGRRTLRTEVDGRGYFVKIHRGIGWGEIAKNLLTAKLPVLGARQEWQAIRRLH 86 Query: 107 YLGVPKYWGSGLHDKNGKSYR---FMIMDRFGS--DLQKI-YEANAKRFSRKTVLQLSLR 160 GV ++ R F++ + DL+ + + + L Sbjct: 87 EAGVATMTAVAYGERGSDPARQHSFIVTEELAPTVDLEVFSQDWRERPPPPRLKRALVEA 146 Query: 161 ILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 + ++ +H H D + LL+ P V D+ L+ Sbjct: 147 VARMVGDMHRAGVNHRDCYICHFLLHTDKP--VSADDFRLS 185 >2PZ1-A nrPDB Length = 466 Score = 30.6 bits (67), Expect = 1.3, Method: Composition-based stats. Identities = 14/86 (16%), Positives = 30/86 (34%), Gaps = 8/86 (9%) Query: 97 QKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRF---SRKT 153 Q + P + K +++ LQK+ + + F + Sbjct: 203 QADFQIYSEYCNNHPN--ACVELSRLTKLSKYVYFFEACRLLQKMIDISLDGFLLTPVQK 260 Query: 154 VLQLSLRILDILEYIHEHEYVHGDIK 179 + + L++ ++L+Y H H D K Sbjct: 261 ICKYPLQLAELLKYTHPQ---HRDFK 283 >6MJ1-A nrPDB Length = 207 Score = 29.8 bits (65), Expect = 1.9, Method: Composition-based stats. Identities = 20/121 (16%), Positives = 46/121 (38%), Gaps = 11/121 (9%) Query: 70 VKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFM 129 +KV D + F Q+ +++ ++ + + S G + Sbjct: 1 MKVSTKDKIIESAVMLFNQKGFSGTSVREIAKSADVNVAHI-----SYYFKGKGGLMEHL 55 Query: 130 IMDRFGSDLQKIYEANAKRFSRKTVLQLSLRIL-DILEYIHEH----EYVHGDIKASNLL 184 + + + K E A S ++ + L+++ DIL Y H H +V+ ++ + L Sbjct: 56 VSEFYEGY-SKTLETAASNISTQSTQEQLLQLVFDILSYQHNHRQLTRFVYREVTIDSTL 114 Query: 185 L 185 + Sbjct: 115 I 115 >5Z3K-A nrPDB Length = 485 Score = 29.8 bits (65), Expect = 2.2, Method: Composition-based stats. Identities = 17/59 (28%), Positives = 20/59 (33%), Gaps = 1/59 (1%) Query: 230 IDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRYRENIASLMDK 288 D V P RR D GY GHLPW D R + E + S + Sbjct: 403 TDMSLNVPP-RRVDARSTGYSGYTLEIGHLPWGDGPHRVVRYRADRDHKGEMLDSHEGR 460 >3NPK-A nrPDB Length = 291 Score = 29.1 bits (63), Expect = 3.1, Method: Composition-based stats. Identities = 13/58 (22%), Positives = 23/58 (39%), Gaps = 11/58 (18%) Query: 132 DRFGSDLQKIYEANAKRFSRK-----------TVLQLSLRILDILEYIHEHEYVHGDI 178 F L + +A K F + +L +L + LE+IH + +H D+ Sbjct: 25 PFFNEALALMLKAGGKHFRAQLLLSVVQSNKPELLNQALDVALALEFIHTYSLIHDDL 82 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.307 0.118 0.300 Lambda K H 0.267 0.0367 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 13,672,248 Number of Sequences: 36641 Number of extensions: 538988 Number of successful extensions: 3971 Number of sequences better than 10.0: 504 Number of HSP's better than 10.0 without gapping: 703 Number of HSP's successfully gapped in prelim test: 183 Number of HSP's that attempted gapping in prelim test: 1756 Number of HSP's gapped (non-prelim): 961 length of query: 396 length of database: 10,336,785 effective HSP length: 99 effective length of query: 297 effective length of database: 6,709,326 effective search space: 1992669822 effective search space used: 1992669822 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.2 bits) S2: 60 (27.9 bits)