BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q96GA7 (329 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 2RKB-A nrPDB 642 0.0 1PWH-A nrPDB 364 e-101 4H27-A nrPDB 348 2e-96 5C3U-A nrPDB 215 2e-56 1TDJ-A nrPDB 111 5e-25 3IAU-A nrPDB 108 3e-24 5X2L-A nrPDB 93 2e-19 1V71-A nrPDB 86 3e-17 5CVC-A nrPDB 84 7e-17 3L6C-A nrPDB 74 9e-14 5JJC-A nrPDB 69 4e-12 2D1F-A nrPDB 68 6e-12 1VE5-A nrPDB 64 1e-10 2GN1-A nrPDB 62 4e-10 6NMX-A nrPDB 60 1e-09 5YGR-A nrPDB 60 1e-09 5YBW-A nrPDB 57 1e-08 1UIN-A nrPDB 57 1e-08 2ZSJ-A nrPDB 57 2e-08 5D84-A nrPDB 50 2e-06 4D9G-A nrPDB 50 2e-06 3FCA-A nrPDB 49 4e-06 5OHX-A nrPDB 46 2e-05 5J5V-A nrPDB 45 3e-05 4I1Y-A nrPDB 45 4e-05 5XA2-A nrPDB 44 7e-05 4LMA-A nrPDB 44 8e-05 6C2H-A nrPDB 44 9e-05 2EGU-A nrPDB 44 1e-04 2BHS-A nrPDB 44 1e-04 5XCN-X nrPDB 44 1e-04 3X43-A nrPDB 43 2e-04 3VBE-A nrPDB 41 6e-04 5B1I-A nrPDB 41 7e-04 4LMB-A nrPDB 41 8e-04 6AHI-A nrPDB 41 0.001 5I7O-A nrPDB 40 0.001 2Q3D-A nrPDB 40 0.002 2JC3-A nrPDB 40 0.002 5XEM-A nrPDB 40 0.002 5XW3-A nrPDB 39 0.002 3PC3-A nrPDB 39 0.003 1M54-A nrPDB 38 0.007 3T4P-A nrPDB 37 0.010 1J0B-A nrPDB 37 0.010 4COO-A nrPDB 37 0.011 5MMS-A nrPDB 37 0.012 4OFX-A nrPDB 36 0.019 2PQM-A nrPDB 36 0.019 2EFY-A nrPDB 36 0.020 5OCW-B nrPDB 35 0.034 1X1Q-A nrPDB 35 0.053 5B55-A nrPDB 35 0.066 4AEC-A nrPDB 32 0.35 2ISQ-A nrPDB 31 0.71 3KYC-B nrPDB 29 2.5 3KYD-B nrPDB 29 3.0 6CNV-B nrPDB 29 3.0 4M40-B nrPDB 28 4.0 1UJN-A nrPDB 28 5.5 4WBT-A nrPDB 27 8.5 >2RKB-A nrPDB Length = 318 Score = 642 bits (1655), Expect = 0.0, Method: Compositional matrix adjust. Identities = 318/318 (100%), Positives = 318/318 (100%) Query: 11 QEPFHVVTPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKKGCRHLVCS 70 QEPFHVVTPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKKGCRHLVCS Sbjct: 1 QEPFHVVTPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKKGCRHLVCS 60 Query: 71 SGGNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTGKVWDEANLRAQEL 130 SGGNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTGKVWDEANLRAQEL Sbjct: 61 SGGNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTGKVWDEANLRAQEL 120 Query: 131 AKRDGWENVPPFDHPLIWKGHASLVQELKAVLRTPPGALVLAVGGGGLLAGVVAGLLEVG 190 AKRDGWENVPPFDHPLIWKGHASLVQELKAVLRTPPGALVLAVGGGGLLAGVVAGLLEVG Sbjct: 121 AKRDGWENVPPFDHPLIWKGHASLVQELKAVLRTPPGALVLAVGGGGLLAGVVAGLLEVG 180 Query: 191 WQHVPIIAMETHGAHCFNAAITAGKLVTLPDITSVAKSLGAKTVAARALECMQVCKIHSE 250 WQHVPIIAMETHGAHCFNAAITAGKLVTLPDITSVAKSLGAKTVAARALECMQVCKIHSE Sbjct: 181 WQHVPIIAMETHGAHCFNAAITAGKLVTLPDITSVAKSLGAKTVAARALECMQVCKIHSE 240 Query: 251 VVEDTEAVSAVQQLLDDERMLVEPACGAALAAIYSGLLRRLQAEGCLPPSLTSVVVIVCG 310 VVEDTEAVSAVQQLLDDERMLVEPACGAALAAIYSGLLRRLQAEGCLPPSLTSVVVIVCG Sbjct: 241 VVEDTEAVSAVQQLLDDERMLVEPACGAALAAIYSGLLRRLQAEGCLPPSLTSVVVIVCG 300 Query: 311 GNNINSRELQALKTHLGQ 328 GNNINSRELQALKTHLGQ Sbjct: 301 GNNINSRELQALKTHLGQ 318 >1PWH-A nrPDB Length = 327 Score = 364 bits (934), Expect = e-101, Method: Compositional matrix adjust. Identities = 197/320 (61%), Positives = 244/320 (76%), Gaps = 1/320 (0%) Query: 9 AKQEPFHVVTPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKKGCRHLV 68 A QE HV TPL +S ALS+VAG VFLK ++ QPSGSFKIRGIGH C+ AK+GC+H V Sbjct: 2 AAQESLHVKTPLRDSMALSKVAGTSVFLKMDSSQPSGSFKIRGIGHLCKMKAKQGCKHFV 61 Query: 69 CSSGGNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTGKVWDEANLRAQ 128 CSS GNAG+A AYAAR+LG+PATIV+P +T ++RL+ EGA V++ G++ DEA A+ Sbjct: 62 CSSAGNAGMATAYAARRLGLPATIVVPSTTPALTIERLKNEGATVEVVGEMLDEAIQLAK 121 Query: 129 ELAKRD-GWENVPPFDHPLIWKGHASLVQELKAVLRTPPGALVLAVGGGGLLAGVVAGLL 187 L K + GW + PFD PLIW+GH SLV+ELK L PGA+VL+VGGGGLL GVV GL Sbjct: 122 ALEKNNPGWVYISPFDDPLIWEGHTSLVKELKETLSAKPGAIVLSVGGGGLLCGVVQGLR 181 Query: 188 EVGWQHVPIIAMETHGAHCFNAAITAGKLVTLPDITSVAKSLGAKTVAARALECMQVCKI 247 EVGW+ VPIIAMET GAH F+AA+ GKLVTLP ITSVAK+LG TV A+ L+ I Sbjct: 182 EVGWEDVPIIAMETFGAHSFHAAVKEGKLVTLPKITSVAKALGVNTVGAQTLKLFYEHPI 241 Query: 248 HSEVVEDTEAVSAVQQLLDDERMLVEPACGAALAAIYSGLLRRLQAEGCLPPSLTSVVVI 307 SEV+ D EAV+A+++ +DDE++LVEPACGAALAA+YSG++ RLQAE L L S+VVI Sbjct: 242 FSEVISDQEAVTAIEKFVDDEKILVEPACGAALAAVYSGVVCRLQAEARLQTPLASLVVI 301 Query: 308 VCGGNNINSRELQALKTHLG 327 VCGG+NI+ +LQALK LG Sbjct: 302 VCGGSNISLAQLQALKAQLG 321 >4H27-A nrPDB Length = 364 Score = 348 bits (892), Expect = 2e-96, Method: Compositional matrix adjust. Identities = 196/317 (61%), Positives = 249/317 (78%), Gaps = 1/317 (0%) Query: 12 EPFHVVTPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKKGCRHLVCSS 71 EP HV TP+ +S ALS++AG V+LK ++ QPSGSFKIRGIGHFC+ AK+GC H VCSS Sbjct: 41 EPLHVKTPIRDSMALSKMAGTSVYLKMDSAQPSGSFKIRGIGHFCKRWAKQGCAHFVCSS 100 Query: 72 GGNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTGKVWDEANLRAQELA 131 GNAG+AAAYAAR+LG+PATIV+P +T ++RL+ EGA V++ G++ DEA A+ LA Sbjct: 101 SGNAGMAAAYAARQLGVPATIVVPGTTPALTIERLKNEGATVKVVGELLDEAFELAKALA 160 Query: 132 KRD-GWENVPPFDHPLIWKGHASLVQELKAVLRTPPGALVLAVGGGGLLAGVVAGLLEVG 190 K + GW +PPFD PLIW+GHAS+V+ELK L PGA+ L+VGGGGLL GVV GL EVG Sbjct: 161 KNNPGWVYIPPFDDPLIWEGHASIVKELKETLWEKPGAIALSVGGGGLLCGVVQGLQEVG 220 Query: 191 WQHVPIIAMETHGAHCFNAAITAGKLVTLPDITSVAKSLGAKTVAARALECMQVCKIHSE 250 W VP+IAMET GAH F+AA TAGKLV+LP ITSVAK+LG KTV A+AL+ Q I SE Sbjct: 221 WGDVPVIAMETFGAHSFHAATTAGKLVSLPKITSVAKALGVKTVGAQALKLFQEHPIFSE 280 Query: 251 VVEDTEAVSAVQQLLDDERMLVEPACGAALAAIYSGLLRRLQAEGCLPPSLTSVVVIVCG 310 V+ D EAV+A+++ +DDE++LVEPACGAALAA+YS ++++LQ EG L L S+VVIVCG Sbjct: 281 VISDQEAVAAIEKFVDDEKILVEPACGAALAAVYSHVIQKLQLEGNLRTPLPSLVVIVCG 340 Query: 311 GNNINSRELQALKTHLG 327 G+NI+ +L+ALK LG Sbjct: 341 GSNISLAQLRALKEQLG 357 >5C3U-A nrPDB Length = 366 Score = 215 bits (548), Expect = 2e-56, Method: Compositional matrix adjust. Identities = 133/318 (41%), Positives = 200/318 (62%), Gaps = 13/318 (4%) Query: 12 EPFHVVTPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFC-QEMAKKGCR-HLVC 69 + HV TPLL + L++ VFLK EN+QPSGS K+RGIG FC Q + +G VC Sbjct: 16 QSLHVATPLLHAPNLTKELECNVFLKMENIQPSGSVKMRGIGAFCYQAVQTRGTNIQFVC 75 Query: 70 SSGGNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTGKVWDEANLRAQE 129 SG N +A +Y AR+LG+ A IV+P++T+ ++ Q ++ +G+ + L G+ W A + A++ Sbjct: 76 GSGPNTVLAVSYCARQLGVEAIIVVPKATNERICQSIRTDGSHLILYGENWTAAEVHARK 135 Query: 130 LAKRDGWENVPPFDHPLIWKGHASLVQELKAVLR-TPPGALVLAVGGGGLLAGVVAGLLE 188 L +R+G VP DH LIW+GH+++VQELK L PP A++ VGGGGLL GV+ GL E Sbjct: 136 LVRRNGIY-VPSSDHALIWQGHSTIVQELKTQLNDNPPAAIICPVGGGGLLNGVIMGLQE 194 Query: 189 VGWQHVPIIAMETHGAHCFNAAITAGKLVTLPDITSVAKSLGAKTVAARALECMQVCKIH 248 W+ VP+IA+ETHG++ F A++ AG+LV + ++A SL +K V++++LE + Sbjct: 195 ADWKDVPVIAVETHGSNAFQASVVAGELVIMEKNNTIATSLISKAVSSKSLELSLNHPVV 254 Query: 249 SEVVEDTEAVSAVQQLLDDERMLVEPACGAALAAIYSGLLRRLQAEGCLPPSLT---SVV 305 V D A AV+ +D +MLVE + GAAL+ Y+ L+R + PSL+ VV Sbjct: 255 PFAVSDAMAADAVRLFAEDFKMLVEASAGAALSLCYTHLIRDIL------PSLSPAKDVV 308 Query: 306 VIVCGGNNINSRELQALK 323 V+V GG++I+ L + Sbjct: 309 VLVTGGSDISLAHLDEYR 326 >1TDJ-A nrPDB Length = 514 Score = 111 bits (277), Expect = 5e-25, Method: Compositional matrix adjust. Identities = 91/287 (31%), Positives = 152/287 (52%), Gaps = 15/287 (5%) Query: 1 MDGPVAEHAKQEPFHVVTPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMA 60 + PV E A+ VTPL + LS + +K E+ QP SFK+RG + Sbjct: 21 LRAPVYEAAQ------VTPLQKMEKLSSRLDNVILVKREDRQPVHSFKLRGAYAMMAGLT 74 Query: 61 KKGCRH-LVCSSGGNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTGKV 119 ++ H ++ +S GN A+++ +LG+ A IV+P +T+ V ++G G EV L G Sbjct: 75 EEQKAHGVITASAGNHAQGVAFSSARLGVKALIVMPTATADIKVDAVRGFGGEVLLHGAN 134 Query: 120 WDEANLRAQELAKRDGWENVPPFDHPLIWKGHASLVQELKAVLRTPPGALVLAVGGGGLL 179 +DEA +A EL+++ G+ VPPFDHP++ G +L EL + + V GGG L Sbjct: 135 FDEAKAKAIELSQQQGFTWVPPFDHPMVIAGQGTLALEL--LQQDAHLDRVFVPVGGGGL 192 Query: 180 AGVVAGLLEVGWQHVPIIAMETHGAHCFNAAITAGKLVTLPDITSVAKSLGAKTVAARAL 239 A VA L++ + +IA+E + C AA+ AG V LP + A+ + K + Sbjct: 193 AAGVAVLIKQLMPQIKVIAVEAEDSACLKAALDAGHPVDLPRVGLFAEGVAVKRIGD--- 249 Query: 240 ECMQVCKIHSE--VVEDTEAV-SAVQQLLDDERMLVEPACGAALAAI 283 E ++C+ + + + D++A+ +A++ L +D R + EP+ ALA + Sbjct: 250 ETFRLCQEYLDDIITVDSDAICAAMKDLFEDVRAVAEPSGALALAGM 296 >3IAU-A nrPDB Length = 366 Score = 108 bits (270), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 74/259 (28%), Positives = 135/259 (52%), Gaps = 7/259 (2%) Query: 18 TPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKKGC-RHLVCSSGGNAG 76 +PL + LS G+ ++K E+ Q SFK+RG + ++++ + ++ +S GN Sbjct: 61 SPLELAEKLSDRLGVNFYIKREDKQRVFSFKLRGAYNMMSNLSREELDKGVITASAGNHA 120 Query: 77 IAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTGKVWDEANLRAQELAKRDGW 136 A A ++L A IV+P +T + ++ G +V L GK +DEA A EL+++DG Sbjct: 121 QGVALAGQRLNCVAKIVMPTTTPQIKIDAVRALGGDVVLYGKTFDEAQTHALELSEKDGL 180 Query: 137 ENVPPFDHPLIWKGHASLVQELKAVLRTPPGALVLAVGGGGLLAGVVAGLLEVGWQHVPI 196 + +PPFD P + KG ++ E+ L+ A+ + VGGGGL+AGV ++ + I Sbjct: 181 KYIPPFDDPGVIKGQGTIGTEINRQLKD-IHAVFIPVGGGGLIAGVATFFKQIA-PNTKI 238 Query: 197 IAMETHGAHCFNAAITAGKLVTLPDITSVAKSLGAKTVAARAL-ECMQVCKIHSEVVEDT 255 I +E +GA ++ G V L ++ + A + V +C ++ I V+ Sbjct: 239 IGVEPYGAASMTLSLHEGHRVKLSNVDTFADGVAVALVGEYTFAKCQEL--IDGMVLVAN 296 Query: 256 EAVS-AVQQLLDDERMLVE 273 + +S A++ + D+ R ++E Sbjct: 297 DGISAAIKDVYDEGRNILE 315 >5X2L-A nrPDB Length = 348 Score = 92.8 bits (229), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 97/321 (30%), Positives = 153/321 (47%), Gaps = 54/321 (16%) Query: 17 VTPLLESWALSQVAGMPVFLKCENVQPSGSFKIRG----IGHFCQEMAKKGCRHLVCSSG 72 +TP+L S L+Q+ G +F KCE Q +GSFKIRG + + ++ + +V S Sbjct: 25 LTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVRSLVPDALERKPKAVVTHSS 84 Query: 73 GNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTGKVWDEANLRAQE-LA 131 GN G A YAA+ GIPA IV+P++ +Q GA + V+ E + ++E +A Sbjct: 85 GNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASI-----VYCEPSDESRENVA 139 Query: 132 KRDGWEN----VPPFDHPLIWKGHASLVQELKAVLRTPP--GALVLAVGGGGLLAGVVAG 185 KR E V P P + G ++ E VL P ALV+ VGGGG+LAG +A Sbjct: 140 KRVTEETEGIMVHPNQEPAVIAGQGTIALE---VLNQVPLVDALVVPVGGGGMLAG-IAI 195 Query: 186 LLEVGWQHVPIIAMETHGA-HCFNAAITAGKLV-------TLPDITSVAKSLGAKTVAAR 237 ++ V + A E A C+ + + GKL+ T+ D V S+G T Sbjct: 196 TVKALKPSVKVYAAEPSNADDCYQSKL-KGKLMPNLYPPETIAD--GVKSSIGLNT---- 248 Query: 238 ALECMQVCKIHSEVVEDTEAVS------AVQQLLDDERMLVEPACGAALAAIYSGLLRRL 291 I ++V+D V+ A Q + + ++L+EP G +AA+ S Sbjct: 249 -------WPIIRDLVDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLS------ 295 Query: 292 QAEGCLPPSLTSVVVIVCGGN 312 Q + P + ++ +++ GGN Sbjct: 296 QHFQTVSPEVKNICIVLSGGN 316 >1V71-A nrPDB Length = 323 Score = 85.5 bits (210), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 49/149 (32%), Positives = 77/149 (51%), Gaps = 7/149 (4%) Query: 14 FHVVTPLLESWALSQVAGMPVFLKCENVQPSGSFKIRG----IGHFCQEMAKKGCRHLVC 69 F TP+L S +++ VF KCEN Q G+FK RG + + K G ++ Sbjct: 23 FANKTPVLTSSTVNKEFVAEVFFKCENFQKMGAFKFRGALNALSQLNEAQRKAG---VLT 79 Query: 70 SSGGNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTGKVWDEANLRAQE 129 S GN A A +A+ LGIPA I++P V +G G +V + + D+ A+E Sbjct: 80 FSSGNHAQAIALSAKILGIPAKIIMPLDAPEAKVAATKGYGGQVIMYDRYKDDREKMAKE 139 Query: 130 LAKRDGWENVPPFDHPLIWKGHASLVQEL 158 +++R+G +PP+DHP + G + +EL Sbjct: 140 ISEREGLTIIPPYDHPHVLAGQGTAAKEL 168 >5CVC-A nrPDB Length = 346 Score = 84.0 bits (206), Expect = 7e-17, Method: Compositional matrix adjust. Identities = 94/330 (28%), Positives = 154/330 (46%), Gaps = 28/330 (8%) Query: 8 HAKQEPFHVVTPLLESWALSQVAGMPVFLKCENVQPSGSFKIRG----IGHFCQEMAKKG 63 A+ P+ TP++ S ++ + G +F KCE Q +G+FKIRG I E KG Sbjct: 27 QARIAPYVHRTPVMSSTSIDAMVGKKLFFKCECFQKAGAFKIRGASNSIFALDDEQVSKG 86 Query: 64 CRHLVCSSGGNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTGKVWDEA 123 +V S GN A A AA+ GIPA IV+P + V+ ++ G + +W +A Sbjct: 87 ---VVTHSSGNHAAAVALAAKLRGIPAHIVIPRNAPASKVENVKCYGGHI-----IWSDA 138 Query: 124 NLRAQE-LAKRDGWENVPPFDHPLIWK----GHASLVQELKAVLRTPP--GALVLAVGGG 176 ++ ++E ++KR E HP+ K G ++ EL L P +++ + GG Sbjct: 139 SIESREYVSKRVQEETGAVLIHPINSKYTISGQGTVSLEL---LEQVPEIDTIIVPISGG 195 Query: 177 GLLAGVVAGLLEVGWQHVPIIAMETHGAHCFNAAITAGKLVTLPDITSVAKSLGAKTVAA 236 GL++GV + + I+A E GA + AGK++TLP ++A L A + Sbjct: 196 GLISGVALAAKAIN-PSIRILAAEPKGADDSAQSKAAGKIITLPSTNTIADGLRA-FLGD 253 Query: 237 RALECMQVCKIHSEVVEDTEAVSAVQQLLDDERMLVEPACGAALAAIYSGLLRRLQAEGC 296 ++ VV+DT V A++ + ++ VEP+ LAA S ++ A Sbjct: 254 LTWPVVRDLVDDVIVVDDTAIVDAMKMCYEILKVAVEPSGAIGLAAALSDEFKQSSAW-- 311 Query: 297 LPPSLTSVVVIVCGGNNINSRELQALKTHL 326 + + +IV GGN Q++ HL Sbjct: 312 --HESSKIGIIVSGGNVDLGTLWQSMYKHL 339 >3L6C-A nrPDB Length = 339 Score = 73.9 bits (180), Expect = 9e-14, Method: Compositional matrix adjust. Identities = 86/318 (27%), Positives = 146/318 (45%), Gaps = 37/318 (11%) Query: 11 QEPFHVVTPLLESWALSQVAGMPVFLKCENVQPSGSFKIRG----IGHFCQEMAKKGCRH 66 Q+ H+ TP+L S L+Q+AG +F KCE Q +GSFKIRG I + + + Sbjct: 20 QDSVHL-TPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLIPDTLEGKPKA 78 Query: 67 LVCSSGGNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTGKVWDEANLR 126 +V S GN G A YAA+ GIPA IV+P++ +Q GA + V+ E + Sbjct: 79 VVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASI-----VYSEPSDE 133 Query: 127 AQE-LAKRDGWEN----VPPFDHPLIWKGHASLVQELKAVLRTPPGALVLAVGGGGLLAG 181 ++E +A+R E V P P + G ++ L+ + + P ++ GGG + Sbjct: 134 SRENVAQRIIQETEGILVHPNQEPAVIAGQGTIA--LEVLNQVPLVDALVVPVGGGGMVA 191 Query: 182 VVAGLLEVGWQHVPIIAMETHGA-HCFNAAITAGKLVTLPDITSVAKSLGAKTVAARALE 240 +A ++ V + A E A C+ + + L ++A G K+ Sbjct: 192 GIAITIKTLKPSVKVYAAEPSNADDCYQSKLKGELTPNLHPPETIAD--GVKSSIG---- 245 Query: 241 CMQVCKIHSEVVEDTEAVS------AVQQLLDDERMLVEPACGAALAAIYSGLLRRLQAE 294 + I ++V+D V+ A Q + + ++L+EP G LAA+ S Q Sbjct: 246 -LNTWPIIRDLVDDVFTVTEDEIKYATQLVWERMKLLIEPTAGVGLAAVLS------QHF 298 Query: 295 GCLPPSLTSVVVIVCGGN 312 + P + ++ +++ GGN Sbjct: 299 QTVSPEVKNICIVLSGGN 316 >5JJC-A nrPDB Length = 342 Score = 68.6 bits (166), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 88/324 (27%), Positives = 140/324 (43%), Gaps = 47/324 (14%) Query: 18 TPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKKGCRH----LVCSSGG 73 TPL+ S++ G ++ K E + P S K R + ++ K+G +V + G Sbjct: 12 TPLIRLSKASELTGCDIYGKAEFLNPGQSVKDRAALYIIRDAEKRGLLRPGGVIVEGTAG 71 Query: 74 NAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAE---------------VQLTGK 118 N GI A+ LG IV+PE+ S + L+ GAE V+L+G+ Sbjct: 72 NTGIGLTMVAKALGYRTAIVIPETASQEKKDALRLLGAELIEVPAAPYRNPNNAVRLSGR 131 Query: 119 VWDEANLRAQELAKRDG----WENVPPFDHPLIWKGH-ASLVQELKAVLRTPPGALVLAV 173 + A++LAK + W N FD+ + + H + QE+ V AV Sbjct: 132 L-------AEQLAKTEPNGAIWAN--QFDNTVNRQAHIETTAQEIWRDTSDQIDGFVAAV 182 Query: 174 GGGGLLAGVVAGLLEVGWQHVPIIAMETHGAHCFNAAITAGKLVTLPDITSVAKSLGAKT 233 G GG LAG GL E ++ I + HGA +A T G+L D S+ + +G Sbjct: 183 GSGGTLAGTAIGLKERN-HNIKIALADPHGA-ALHAFYTTGELKAEGD--SITEGIGQGR 238 Query: 234 VAARALECMQVCKIHSEVVEDTEAVSAVQQLLDDERMLVEPACGAALAAIYSGLLRRLQA 293 + A LE S + D EA+ + L+++E + + + G +A G +R + Sbjct: 239 ITAN-LEGF--TPDFSYQIPDAEALDILFALVEEEGLCLGGSSGINIA----GAIRLAKD 291 Query: 294 EGCLPPSLTSVVVIVCGGNNINSR 317 G P T V V+ GN S+ Sbjct: 292 LG---PGHTIVTVLCDYGNRYQSK 312 >2D1F-A nrPDB Length = 360 Score = 67.8 bits (164), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 80/311 (25%), Positives = 136/311 (43%), Gaps = 16/311 (5%) Query: 18 TPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKKGCRHLVCSSGGNAGI 77 TPL+ + LS+ G + LK E + P+GSFK RG+ + G R ++C+S GN Sbjct: 39 TPLIAATNLSKQTGCTIHLKVEGLNPTGSFKDRGMTMAVTDALAHGQRAVLCASTGNTSA 98 Query: 78 AAAYAARKLGIPATIVLPESTSL--QVVQRLQGEGAEVQLTGKVWDEANLRAQELAKRDG 135 +AA A + GI +++P+ ++ Q + +Q+ G +D+ A+++A Sbjct: 99 SAAAYAARAGITCAVLIPQGKIAMGKLAQAVMHGAKIIQIDGN-FDDCLELARKMAADFP 157 Query: 136 WENVPPFDHPLIWKGHASLVQELKAVLRTPPGALVLAVGGGGLLAGVVAGLLEVGWQHVP 195 ++ +P+ +G + E+ VL T P L VG G + G E + + Sbjct: 158 TISLVNSVNPVRIEGQKTAAFEIVDVLGTAPDVHALPVGNAGNITAYWKGYTE--YHQLG 215 Query: 196 IIAM--ETHGAHCFNAA-ITAGKLVTLPDITSVAKSLGAKTVAARALECMQVCKIHSEVV 252 +I G AA + G+ V+ P+ + A +G+ A+E Q K Sbjct: 216 LIDKLPRMLGTQAAGAAPLVLGEPVSHPETIATAIRIGSPASWTSAVEAQQQSKGRFLAA 275 Query: 253 EDTEAVSAVQQLLDDERMLVEPACGAALAAIYSGLLRRLQAEGCLPPSLTSVVVIVCGGN 312 D E ++A + E + VEPA A++A + + A G S VV GN Sbjct: 276 SDEEILAAYHLVARVEGVFVEPASAASIAGLLKAIDDGWVARG-------STVVCTVTGN 328 Query: 313 NINSRELQALK 323 + + ALK Sbjct: 329 GLKDPD-TALK 338 >1VE5-A nrPDB Length = 311 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 51/148 (34%), Positives = 73/148 (49%), Gaps = 2/148 (1%) Query: 13 PFHVVTPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKKGCRHLVCSSG 72 P+ TPLL S L + G + LK E++Q +GSFK RG + +A + + L+ S Sbjct: 16 PYTHRTPLLTSRLLDGLLGKRLLLKAEHLQKTGSFKARGA--LSKALALENPKGLLAVSS 73 Query: 73 GNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTGKVWDEANLRAQELAK 132 GN AYAA+ LG+ A +V+PE S + GAEV G A+ L + Sbjct: 74 GNHAQGVAYAAQVLGVKALVVMPEDASPYKKACARAYGAEVVDRGVTAKNREEVARALQE 133 Query: 133 RDGWENVPPFDHPLIWKGHASLVQELKA 160 G+ + PFD PL+ G + EL A Sbjct: 134 ETGYALIHPFDDPLVIAGQGTAGLELLA 161 >2GN1-A nrPDB Length = 342 Score = 61.6 bits (148), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 40/142 (28%), Positives = 67/142 (47%), Gaps = 1/142 (0%) Query: 18 TPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKKGCRH-LVCSSGGNAG 76 T + S S+ +FLK EN+Q +GSFKIRG + + + R +V S GN Sbjct: 41 TGMPRSNYFSERCKGEIFLKFENMQRTGSFKIRGAFNKLSSLTEAEKRKGVVACSAGNHA 100 Query: 77 IAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTGKVWDEANLRAQELAKRDGW 136 + + LGI +V+P+ V AEV L G +++ + E+ + +G Sbjct: 101 QGVSLSCAMLGIDGKVVMPKGAPKSKVAATCDYSAEVVLHGDNFNDTIAKVSEIVETEGR 160 Query: 137 ENVPPFDHPLIWKGHASLVQEL 158 +PP+D P + G ++ E+ Sbjct: 161 IFIPPYDDPKVIAGQGTIGLEI 182 >6NMX-A nrPDB Length = 354 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 73/302 (24%), Positives = 135/302 (44%), Gaps = 17/302 (5%) Query: 18 TPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKKGCRHLVCSSGGNAGI 77 TPL+ LS+ G+ + +K E V P+GSFK RG+ + ++G ++C+S GN Sbjct: 31 TPLIHLPKLSEQLGIELHVKTEGVNPTGSFKDRGMVMAVAKAKEEGNDTIMCASTGNTSA 90 Query: 78 AAAYAARKLGIPATIVLPE-STSLQVVQRLQGEGAEVQLTGKVWDEANLRAQELAKRDGW 136 AAA A + + +++P + + + GAE+ +D+A + + ++ Sbjct: 91 AAAAYAARANMKCIVIIPNGKIAFGKLAQAVMYGAEIIAIDGNFDDALKIVRSICEKSPI 150 Query: 137 ENVPPFDHPLIWKGHASLVQELKAVLRTPPGALVLAVGGGGLLAGVVAGLLEV----GWQ 192 V + P +G + E+ L P L + VG G ++ G E G Sbjct: 151 ALVNSVN-PYRLEGQKTAAFEVCEQLGEAPDVLAIPVGNAGNISAYWKGFKEYHEKNGTS 209 Query: 193 HVPIIAMETHGAHCFNAAITAGKLVTLPDITSVAKSLGAKTVAARALECMQVCKIHSEVV 252 + E G+ AAI +++ P+ + A +G +A++ + + V Sbjct: 210 LPKMRGFEAEGS----AAIVRNEVIENPETIATAIRIGNPASWDKAVKAAEESNGKIDEV 265 Query: 253 EDTEAVSAVQQLLDDERMLVEPACGAALAAIYSGLLRRLQAEGCLPPSLTSVVVIVCGGN 312 D E + A Q + +E + EP A++A G+L+++++ G +P S VV V GN Sbjct: 266 TDDEILHAYQLIAREEGVFAEPGSCASIA----GVLKQVKS-GEIPKG--SKVVAVLTGN 318 Query: 313 NI 314 + Sbjct: 319 GL 320 >5YGR-A nrPDB Length = 404 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 45/157 (28%), Positives = 76/157 (48%), Gaps = 20/157 (12%) Query: 67 LVCSSGGNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTGKVWDEANLR 126 V ++ GN G A+AA +LG+ A + +P+ +SL + ++ GAE +T +D+A Sbjct: 120 FVTATDGNHGRGVAWAAEQLGLKAVVYMPKGSSLIRAENIRHHGAECTITDLNYDDAVRL 179 Query: 127 AQELAKRDGW-----------ENVPPFDHPLIWKGHASLVQELKAVL---RTP-PGALVL 171 A +A+ GW E +P + I +G+ +L E L +P P L+L Sbjct: 180 AHRMAQTKGWVLLQDTAWTGYEEIPTW----IMQGYMTLAVEAYEQLAETNSPLPTHLIL 235 Query: 172 AVGGGGLLAGVVAGLLEVGWQHVP-IIAMETHGAHCF 207 G G V+ +E +++P II +E H A+C Sbjct: 236 QAGVGSFAGSVMGYFVEKMQENIPNIIVVEPHQANCL 272 >5YBW-A nrPDB Length = 329 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 46/175 (26%), Positives = 82/175 (46%), Gaps = 11/175 (6%) Query: 16 VVTPLLESWALSQV----AGMPVFLKCENVQPSGSFKIRGIGH--FCQEMAKKGCRHLVC 69 + TP+ S ++ AG + K EN+Q +GSFK RG + C + +V Sbjct: 23 LYTPVFTSPTFDRMVGSKAGRQFYFKAENLQKTGSFKARGALNAILCALEREPSLAGVVT 82 Query: 70 SSGGNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTGKVWDEANLRAQE 129 S GN G A A+A+++ G+ +V+P++ ++ GAEV + Sbjct: 83 HSSGNHGQALAWASKRAGVKCCVVVPKTAPQVKFDAMENYGAEVVKCEPNPTSRKETCEG 142 Query: 130 LAKRDGWENVPPFDHPLIWKGHASLVQELKAVLRTPP--GALVLAVGGGGLLAGV 182 LAK G++ + D + G ++ EL L+ P A++++V GG+ +G+ Sbjct: 143 LAKSRGYKYISSSDDYDVIAGQGTIALEL---LQQQPDLDAILVSVSAGGMASGI 194 >1UIN-A nrPDB Length = 351 Score = 56.6 bits (135), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 80/287 (27%), Positives = 122/287 (42%), Gaps = 16/287 (5%) Query: 31 GMPVFLKCENVQPSGSFKIRGIGHFCQEMAKKGCRHLVCSSGGNAGIAAAYAARKLGIPA 90 G+ ++ K E + P+GSFK RG+ + + G + + C+S GN +AA A + GI A Sbjct: 44 GIRLYAKYEGLNPTGSFKDRGMTLAVSKAVEGGAQAVACASTGNTAASAAAYAARAGILA 103 Query: 91 TIVLPESTSL--QVVQRLQGEGAEVQLTGKVWDEANLRAQELAKRDGWENVPPFDHPLIW 148 +VLP +V Q L VQ+ G +D+A Q+L + V + P Sbjct: 104 IVVLPAGYVALGKVAQSLVHGARIVQVEGN-FDDALRLTQKLTEAFPVALVNSVN-PHRL 161 Query: 149 KGHASLVQELKAVLRTPPGALVLAVGGGGLLAGVVAGLLEVGWQHVPIIAMETHGAHCFN 208 +G +L E+ L P L VG G + A + H A F Sbjct: 162 EGQKTLAFEVVDELGDAPHYHALPVGNAG---NITAHWMGYKAYHALGKAKRLPRMLGFQ 218 Query: 209 AA----ITAGKLVTLPDITSVAKSLGAKTVAARALECMQVCKIHSEVVEDTEAVSAVQQL 264 AA + G+ V P+ + A +G A+ + E V D E + A + L Sbjct: 219 AAGAAPLVLGRPVERPETLATAIRIGNPASWQGAVRAKEESGGVIEAVTDEEILFAYRYL 278 Query: 265 LDDERMLVEPACGAALAAIYSGLLRRLQAEGCLPPSLTSVVVIVCGG 311 +E + EPA AA+A ++ LLR EG L P T V+ + G Sbjct: 279 AREEGIFCEPASAAAMAGVFK-LLR----EGRLEPESTVVLTLTGHG 320 >2ZSJ-A nrPDB Length = 352 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 69/279 (24%), Positives = 125/279 (44%), Gaps = 23/279 (8%) Query: 18 TPLLESWALSQVAGMP--VFLKCENVQPSGSFKIRGIGHFCQEMAKKGCRHLVCSSGGNA 75 TPL+E+ L++ G ++LK E + P+GSFK RG+ + + G R ++C+S GN Sbjct: 31 TPLIEADNLARAIGFKGKIYLKYEGLNPTGSFKDRGMTLAISKAVEAGKRAVICASTGNT 90 Query: 76 GIAAAYAARKLGIPATIVLPE-STSLQVVQRLQGEGAEVQLTGKVWDEANLRAQELAKRD 134 +AA A + G+ A ++LP+ + ++ + + GA+V +D+ A + ++ Sbjct: 91 SASAAAYAARAGLRAYVLLPKGAVAIGKLSQAMIYGAKVLAIQGTFDD----ALNIVRKI 146 Query: 135 GWENVP----PFDHPLIWKGHASLVQELKAVLRTPPGALVLAVGGGGLLAGVVAGLLEVG 190 G EN P +P +G + E+ L P + VG G + G ++ Sbjct: 147 G-ENFPVEIVNSVNPYRIEGQKTAAFEICDTLGEAPDYHFIPVGNAGNITAYWKG-FKIY 204 Query: 191 WQHVPIIAM------ETHGAHCFNAAITAGKLVTLPDITSVAKSLGAKTVAARALECMQV 244 ++ I + + GA A I G + P + A +G AL+ Q Sbjct: 205 YEEGKITKLPRMMGWQAEGA----APIVKGYPIKNPQTIATAIKIGNPYSWKSALKAAQE 260 Query: 245 CKIHSEVVEDTEAVSAVQQLLDDERMLVEPACGAALAAI 283 + V D+E + A + + E + EPA A++A + Sbjct: 261 SGGKIDAVSDSEILYAYKLIASTEGVFCEPASAASVAGL 299 >5D84-A nrPDB Length = 326 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 65/263 (24%), Positives = 111/263 (42%), Gaps = 28/263 (10%) Query: 34 VFLKCENVQPSGSFKIRGIGHFCQEMAKKGC----RHLVCSSGGNAGIAAAYAARKLGIP 89 VF K E + P GS K R + + K G HL+ S+ GN GIA A A+ G+ Sbjct: 33 VFAKLEYMNPGGSMKDRPAKYIIEHGIKHGLITENTHLIESTSGNLGIALAMIAKIKGLK 92 Query: 90 ATIVLPESTSLQVVQRLQGEGAEVQLT------GKVWDEANLRAQE-LAKRDGWENVPPF 142 T V+ S ++ ++ GA V++ G + QE LA D + + Sbjct: 93 LTCVVDPKISPTNLKIIKSYGANVEMVEEPDAHGGYLMTRIAKVQELLATIDDAYWINQY 152 Query: 143 DHPLIWKGHASLV-QELKAVLRTPPGALVLAVGGGGLLAGVVAGLLEVGWQHVPIIAMET 201 + L W+ H E+ ++ P V V G + G+ + EV + I+A++ Sbjct: 153 ANELNWQSHYHGAGTEIVETIKQPIDYFVAPVSTTGSIMGMSRKIKEV-HPNAQIVAVDA 211 Query: 202 HGAHCFNAAITAGKLVTLPDITSVAKSLGAKTVAARALECMQVCKIHSEV-VEDTEAVSA 260 G+ F + LP I A+R E + +I+ + V+D ++ Sbjct: 212 KGSVIFGDKPINRE---LPGIG-----------ASRVPEILNRSEINQVIHVDDYQSALG 257 Query: 261 VQQLLDDERMLVEPACGAALAAI 283 ++L+D E + + G+ +AAI Sbjct: 258 CRKLIDYEGIFAGGSTGSIIAAI 280 >4D9G-A nrPDB Length = 398 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 43/168 (25%), Positives = 78/168 (46%), Gaps = 19/168 (11%) Query: 67 LVCSSGGNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTGKVWDEANLR 126 ++ GN G A+AA++LG A I +P+ ++ + V + GAE +T +D+ Sbjct: 115 FATTTDGNHGRGVAWAAQQLGQNAVIYMPKGSAQERVDAILNLGAECIVTDMNYDDTVRL 174 Query: 127 AQELAKRDGWE-----------NVPPFDHPLIWKGHASLVQELKAVLR---TPPGALVLA 172 + A++ GWE +P + I +G+A+L E +R P ++L Sbjct: 175 TMQHAQQHGWEVVQDTAWEGYTKIPTW----IMQGYATLADEAVEQMREMGVTPTHVLLQ 230 Query: 173 VGGGGLLAGVVAGLLEV-GWQHVPIIAMETHGAHCFNAAITAGKLVTL 219 G G + GV+ L++V Q++ I +E A C + G +V + Sbjct: 231 AGVGAMAGGVLGYLVDVYSPQNLHSIIVEPDKADCIYRSGVKGDIVNV 278 >3FCA-A nrPDB Length = 291 Score = 48.5 bits (114), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 67/254 (26%), Positives = 114/254 (44%), Gaps = 17/254 (6%) Query: 34 VFLKCENVQPSGSFKIRGIGHFCQEMAKKGC--RHLVCSSGGNAGIAAAYAARKLGIPAT 91 + LK E P GS K R + K+G +V + GN GIA A K G Sbjct: 21 IALKLEKNNPGGSVKDRPALFMILDAEKRGLLKNGIVEPTSGNMGIAIAMIGAKRGHRVI 80 Query: 92 IVLPESTSLQVVQRLQGEGAEVQLT-GKVWDEANL-RAQELAKRDGWENVPPFDHPL-IW 148 + +PE+ S++ + L+ GAE+ LT G++ + + +A E+++ G + F++P ++ Sbjct: 81 LTMPETMSVERRKVLKMLGAELVLTPGELGMKGAVEKALEISRETGAHMLNQFENPYNVY 140 Query: 149 KGHASLVQELKAVLRTPPGALVLAVGGGGLLAGVVAGLLEVGWQHVPIIAMETHGAHCFN 208 + E+ + A V VG GG ++GV L V I+A+E + + Sbjct: 141 SHQFTTGPEILKQMDYQIDAFVAGVGTGGTISGVGRVLKGFFGNGVKIVAVEPAKSPVLS 200 Query: 209 AAITAGKLVTLPDITSVAKSLGAKTVAARALECMQVCKIHSEVVEDTEAVSAVQQLLDDE 268 GK + +GA V + L+ + ++ + VED EA + L E Sbjct: 201 GG-QPGK--------HAIQGIGAGFV-PKILDRSVIDEVIT--VEDEEAYEMARYLAKKE 248 Query: 269 RMLVEPACGAALAA 282 +LV + GA +AA Sbjct: 249 GLLVGISSGANVAA 262 >5OHX-A nrPDB Length = 504 Score = 45.8 bits (107), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 32/102 (31%), Positives = 48/102 (47%), Gaps = 6/102 (5%) Query: 18 TPLLESWALSQVAGMP--VFLKCENVQPSGSFKIRGIGHFCQEMAKKGCRHLVCS----S 71 TPL++ + + G+ ++ KCE + P GS K R Q+ KG C+ + Sbjct: 46 TPLIKLNNIPKSYGIKCEIYAKCEFLNPGGSVKDRIAYRMIQDAEDKGLLKPGCTIIEPT 105 Query: 72 GGNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEV 113 GN GI A AA G IV+PE S + + L GA++ Sbjct: 106 SGNTGIGLAMAAAVRGYKCIIVMPEKMSDEKISTLYALGAKI 147 >5J5V-A nrPDB Length = 323 Score = 45.4 bits (106), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 33/103 (32%), Positives = 51/103 (49%), Gaps = 7/103 (6%) Query: 18 TPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKKGCR----HLVCSSGG 73 TPL+ L+++ + K E+ PS S K R + + K+G LV + G Sbjct: 15 TPLVR---LNRIGNGRILAKVESRNPSFSVKCRIGANMIWDAEKRGVLKPGVELVEPTSG 71 Query: 74 NAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLT 116 N GIA AY A G T+ +PE+ S++ + L+ GA + LT Sbjct: 72 NTGIALAYVAAARGYKLTLTMPETMSIERRKLLKALGANLVLT 114 >4I1Y-A nrPDB Length = 314 Score = 45.4 bits (106), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 44/148 (29%), Positives = 68/148 (45%), Gaps = 9/148 (6%) Query: 18 TPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKKG-----CRHLVCSSG 72 TPL+ ++ A V K E+ P+GS K R IG + A+K ++ + Sbjct: 18 TPLVRLRRVTDGAAADVVAKLESFNPAGSIKDR-IGVAMIDAAEKAGLIKPDTIILEPTS 76 Query: 73 GNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTGKVWDEAN--LRAQEL 130 GN GIA A + G + +P++ S++ L+ GAE+ LT A +A+EL Sbjct: 77 GNTGIALAMVSAARGYKCVLTMPDTMSIERRMLLRAYGAELVLTPGAEGMAGAIAKAEEL 136 Query: 131 AKRDGWENVP-PFDHPLIWKGHASLVQE 157 AK D +P F++P HA E Sbjct: 137 AKTDDRYFIPQQFENPANPAVHAVTTAE 164 >5XA2-A nrPDB Length = 309 Score = 44.3 bits (103), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 41/134 (30%), Positives = 60/134 (44%), Gaps = 6/134 (4%) Query: 18 TPLLESWALSQVAGMPVFLKCENVQPSGSFKIR----GIGHFCQEMAKKGCRHLVCSSGG 73 TPL++ L+ V K E P+ S K R I Q K H+V + G Sbjct: 14 TPLVQINRLTAGLSSRVLAKIEGRNPAYSVKCRIGAAMIWDAEQSGKLKPGMHVVEPTSG 73 Query: 74 NAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLT--GKVWDEANLRAQELA 131 N GIA A+ G T+ +PE+ S++ L+ GA++ LT A +A+ELA Sbjct: 74 NTGIALAFVCAARGYKLTLTMPETMSIERRMMLKSFGADLVLTPGADGMKGAISKAEELA 133 Query: 132 KRDGWENVPPFDHP 145 + GW F +P Sbjct: 134 AQPGWFIPQQFKNP 147 >4LMA-A nrPDB Length = 326 Score = 43.9 bits (102), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 40/131 (30%), Positives = 59/131 (45%), Gaps = 15/131 (11%) Query: 15 HVVTPLLESWALSQVAGMP--------VFLKCENVQPSGSFKIRGIGHFCQEMAKKGCRH 66 H VT L+ L Q+ +P + +K E + P+ S K R H K G + Sbjct: 12 HDVTELVGRTPLVQLNRIPQAEGCLGRIVMKLEGMNPAASVKDRIGTHMINSAEKAGLIN 71 Query: 67 -----LVCSSGGNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLT--GKV 119 LV + GN GIA A A G + +PE+ SL+ L+ GA ++LT + Sbjct: 72 PETTVLVEPTSGNTGIALAMTAAAKGYRLILTMPETMSLERRAMLKAYGATLELTPGSQG 131 Query: 120 WDEANLRAQEL 130 A LRAQ++ Sbjct: 132 MKGAILRAQQI 142 >6C2H-A nrPDB Length = 375 Score = 43.9 bits (102), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 68/285 (23%), Positives = 107/285 (37%), Gaps = 27/285 (9%) Query: 18 TPLLESWALSQVAGMP--VFLKCENVQPSGSFKIRGIGHFCQEMAKKGCRH-----LVCS 70 TPL+ L + G+ ++ K E P GS K R +E G H L+ Sbjct: 43 TPLIALKKLPKALGIKPQIYAKLELYNPGGSIKDRIAKSMVEEAEASGRIHPSRSTLIEP 102 Query: 71 SGGNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEV--QLTGKVWDEANLR-- 126 + GN GI A G I LPE S + V L+ GAE+ T WD Sbjct: 103 TSGNTGIGLALIGAIKGYRTIITLPEKMSNEKVSVLKALGAEIIRTPTAAAWDSPESHIG 162 Query: 127 -AQELAKR-------DGWENVPPFDHPLIWKGHASLVQELKAVLRTPPGALVLAVGGGGL 178 A++L K D + N+ + G Q L A+V G GG Sbjct: 163 VAKKLEKEIPGAVILDQYNNMMNPEAHYFGTGREIQRQLEDLNLFDNLRAVVAGAGTGGT 222 Query: 179 LAGVVAGLLEVGWQHVPIIAMETHGAHCFNAAITAGKLVTLPDITSVAKSLGAKTVAARA 238 ++G+ L E + I+ GA F + + + + DIT + Sbjct: 223 ISGISKYLKEQN-DKIQIV-----GADPFGSILAQPENLNKTDITDYKVEGIGYDFVPQV 276 Query: 239 LECMQVCKIHSEVVEDTEAVSAVQQLLDDERMLVEPACGAALAAI 283 L+ + + +D + +QL+ +E +LV + G+A A+ Sbjct: 277 LDRKLIDVWYK--TDDKPSFKYARQLISNEGVLVGGSSGSAFTAV 319 >2EGU-A nrPDB Length = 308 Score = 43.5 bits (101), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 36/110 (32%), Positives = 54/110 (49%), Gaps = 8/110 (7%) Query: 34 VFLKCENVQPSGSFKIRGIGHFCQEMAKKGCR-----HLVCSSGGNAGIAAAYAARKLGI 88 V+LK E + P S K R I E A+K + +V + GN GI A A G Sbjct: 31 VYLKLEFMNPGSSVKDR-IALAMIEAAEKAGKLKPGDTIVEPTSGNTGIGLAMVAAAKGY 89 Query: 89 PATIVLPESTSLQVVQRLQGEGAEVQLT--GKVWDEANLRAQELAKRDGW 136 A +V+P++ SL+ L+ GAE+ LT + A +A+EL + G+ Sbjct: 90 KAVLVMPDTMSLERRNLLRAYGAELVLTPGAQGMRGAIAKAEELVREHGY 139 >2BHS-A nrPDB Length = 303 Score = 43.5 bits (101), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 39/134 (29%), Positives = 62/134 (46%), Gaps = 6/134 (4%) Query: 18 TPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKKG----CRHLVCSSGG 73 TPL++ + G V+LK E P+GS K R E K+G L+ ++ G Sbjct: 11 TPLVKLQRMGPDNGSEVWLKLEGNNPAGSVKDRAALSMIVEAEKRGEIKPGDVLIEATSG 70 Query: 74 NAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTGKVWDEANLR--AQELA 131 N GIA A A G +++P++ S + ++ GAE+ L K R A E+A Sbjct: 71 NTGIALAMIAALKGYRMKLLMPDNMSQERRAAMRAYGAELILVTKEQGMEGARDLALEMA 130 Query: 132 KRDGWENVPPFDHP 145 R + + F++P Sbjct: 131 NRGEGKLLDQFNNP 144 >5XCN-X nrPDB Length = 350 Score = 43.5 bits (101), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 30/87 (34%), Positives = 43/87 (49%), Gaps = 4/87 (4%) Query: 34 VFLKCENVQPSGSFKIRGIGHFCQEMAKKGC----RHLVCSSGGNAGIAAAYAARKLGIP 89 V +K E PS S K R + + K G + +V ++ GN GIA AY A G Sbjct: 62 VVVKIEGRNPSYSVKCRIGANMVWQAEKDGTLTKGKEIVDATSGNTGIALAYVAAARGYK 121 Query: 90 ATIVLPESTSLQVVQRLQGEGAEVQLT 116 T+ +PE+ SL+ + L G G + LT Sbjct: 122 ITLTMPETMSLERKRLLCGLGVNLVLT 148 >3X43-A nrPDB Length = 332 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 36/119 (30%), Positives = 58/119 (48%), Gaps = 8/119 (6%) Query: 34 VFLKCENVQPSGSFKIR-----GIGHFCQEMAKKGCRHLVCSSGGNAGIAAAYAARKLGI 88 V++K E+ P GS K R + + + K G + C+SG N GIA A A G Sbjct: 29 VYVKVESFNPGGSVKDRLALSVVLDAEAKGLLKPGDTIVECTSG-NVGIALAMVAAARGY 87 Query: 89 PATIVLPESTSLQVVQRLQGEGAE-VQLTGKVWDEA-NLRAQELAKRDGWENVPPFDHP 145 V+ ++ S++ + ++ G + V G + + NL A ELA++ GW FD+P Sbjct: 88 RFVAVMGDTYSVERRKLIRAYGGKLVLFPGHLGSKGGNLIADELAEKYGWFRARQFDNP 146 >3VBE-A nrPDB Length = 344 Score = 41.2 bits (95), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 31/104 (29%), Positives = 50/104 (48%), Gaps = 5/104 (4%) Query: 18 TPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKK-----GCRHLVCSSG 72 TPL+ +++ G V +K E +QP+ S K R + +K G L+ + Sbjct: 36 TPLVYLNKVTEGCGAYVAVKQEMMQPTASIKDRPAYAMITDAEEKNLITPGKTTLIEPTS 95 Query: 73 GNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLT 116 GN GI+ A+ A G + +P TSL+ ++ GAE+ LT Sbjct: 96 GNMGISMAFMAAMKGYKMVLTMPSYTSLERRVTMRAFGAELILT 139 >5B1I-A nrPDB Length = 311 Score = 41.2 bits (95), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 44/161 (27%), Positives = 70/161 (43%), Gaps = 8/161 (4%) Query: 34 VFLKCENVQPSGSFKIRGIGHFCQEMAKKGCRH----LVCSSGGNAGIAAAYAARKLGIP 89 ++ K E P GS R + ++ ++G + ++ + GN GI A A + + Sbjct: 28 IYAKLEMFNPGGSIADRLGAYLIEDGLQRGRVNAKTTIIEPTAGNTGIGLALATQAHHLR 87 Query: 90 ATIVLPESTSLQVVQRLQGEGAEVQLTGKV--WDEANLRAQELAKRDGWENVP-PFDHPL 146 +V+PE S++ +Q GAE+ T A +A+ LA VP F +P Sbjct: 88 TILVVPEKFSMEKQVLMQALGAEIVHTPSEEGIKGAIRKAEALAATISNSYVPMQFKNPA 147 Query: 147 IWKGHA-SLVQELKAVLRTPPGALVLAVGGGGLLAGVVAGL 186 + +L E+ A + P A V G GG AGV A L Sbjct: 148 NPAAYYHTLAPEILADMPAPITAFVAGAGSGGTFAGVAAYL 188 >4LMB-A nrPDB Length = 322 Score = 40.8 bits (94), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 34/114 (29%), Positives = 54/114 (47%), Gaps = 12/114 (10%) Query: 34 VFLKCENVQPSGSFKIRGIGHFCQEMAKKGCRH-----LVCSSGGNAGIAAAYAARKLGI 88 + +K E++ P+ S K R ++ G H LV + GN GIA A A G Sbjct: 39 IVVKLESMNPAASVKDRIGVSMVEDAEAAGLIHPDKTILVEPTSGNTGIALAMVAAAKGY 98 Query: 89 PATIVLPESTSLQVVQRLQGEGAEVQLT--GKVWDEANLRAQELAKRDGWENVP 140 + +PE+ SL+ L+ GA+++LT + + A RA+E+ EN P Sbjct: 99 RLVLTMPETMSLERRAMLKAYGAQLELTPGSQGMEGAITRAEEIV-----ENTP 147 >6AHI-A nrPDB Length = 314 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 65/262 (24%), Positives = 108/262 (41%), Gaps = 32/262 (12%) Query: 34 VFLKCENVQPSGSFKIRGIGHFCQEMAKKGC----RHLVCSSGGNAGIAAAYAARKLGIP 89 ++ K E++ P GS K R + E K G ++ + GN GIA A A K + Sbjct: 32 IYAKLEHLNPGGSVKDRLGQYLIGEGFKTGKITSKTTIIEPTAGNTGIALALVAIKHHLK 91 Query: 90 ATIVLPESTSLQVVQRLQGEGAEV--QLTGKVWDEANLRAQELAKRDGWENVPPFDHPLI 147 V+PE S + Q ++ GA V T + A +++ELA E++P PL Sbjct: 92 TIFVVPEKFSTEKQQIMRALGALVINTPTSEGISGAIKKSKELA-----ESIPDSYLPLQ 146 Query: 148 WKG-------HASLVQELKAVLRTPPGALVLAVGGGGLLAGVVAGLLEVGWQHVPIIAME 200 ++ + +L E+ L T + V +G GG AG L E +P A+ Sbjct: 147 FENPDNPAAYYHTLAPEIVQELGTNLTSFVAGIGSGGTFAGTARYLKE----RIP--AIR 200 Query: 201 THGAHCFNAAITAGKLVTLPDITSVAKSLGAKTVAARALECMQVCKIHSEVVEDTEAVSA 260 G + + G+ P + + +G + + E + + E + D E S Sbjct: 201 LIGVEPEGSILNGGE----PGPHEI-EGIGVEFIPP-FFENLDIDGF--ETISDEEGFSY 252 Query: 261 VQQLLDDERMLVEPACGAALAA 282 ++L +LV + GAA A Sbjct: 253 TRKLAKKNGLLVGSSSGAAFVA 274 >5I7O-A nrPDB Length = 326 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 26/84 (30%), Positives = 43/84 (51%), Gaps = 4/84 (4%) Query: 34 VFLKCENVQPSGSFKIRGIGHFCQEMAKKGCRH----LVCSSGGNAGIAAAYAARKLGIP 89 ++ K E+ P+GS K R ++ G ++ + GN GI+ A AAR G Sbjct: 40 LWAKLEDRNPTGSIKDRPAVRMIEQAEADGLLRPGATILEPTSGNTGISLAMAARLKGYR 99 Query: 90 ATIVLPESTSLQVVQRLQGEGAEV 113 V+PE+TS++ Q L+ GA++ Sbjct: 100 LICVMPENTSVERRQLLELYGAQI 123 >2Q3D-A nrPDB Length = 313 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 42/136 (30%), Positives = 62/136 (45%), Gaps = 9/136 (6%) Query: 18 TPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAK-----KGCRHLVCSSG 72 TPL+ ++ A + K E P+ S K R IG + A+ K ++ + Sbjct: 17 TPLVRLRRVTDGAVADIVAKLEFFNPANSVKDR-IGVAMLQAAEQAGLIKPDTIILEPTS 75 Query: 73 GNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLT--GKVWDEANLRAQEL 130 GN GIA A G + +PE+ SL+ L+ GAE+ LT A +A+EL Sbjct: 76 GNTGIALAMVCAARGYRCVLTMPETMSLERRMLLRAYGAELILTPGADGMSGAIAKAEEL 135 Query: 131 AKRDGWENVP-PFDHP 145 AK D VP F++P Sbjct: 136 AKTDQRYFVPQQFENP 151 >2JC3-A nrPDB Length = 303 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 41/150 (27%), Positives = 64/150 (42%), Gaps = 18/150 (12%) Query: 18 TPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKKG----CRHLVCSSGG 73 TPL++ + G +++K E P+GS K R E K+G L+ ++ G Sbjct: 11 TPLVKLQRIGPDNGSEIWVKLEGNNPAGSVKDRAALSMIVEAEKRGEIKPGDVLIEATSG 70 Query: 74 NAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTGKVWDEANLRAQELAKR 133 N GIA A A G +++P++ S + ++ GAE+ L K R LA Sbjct: 71 NTGIALAMIAALKGYRMKLLMPDNMSQERRAAMRAYGAELILVTKEQGMEGARDLALAMS 130 Query: 134 DGWE-------NVP--PFDH-----PLIWK 149 + E N P P+ H P IW+ Sbjct: 131 ERGEGKLLDQFNNPDNPYAHYTTTGPEIWR 160 >5XEM-A nrPDB Length = 310 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 36/129 (27%), Positives = 61/129 (47%), Gaps = 7/129 (5%) Query: 18 TPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKKGCRH----LVCSSGG 73 TPL++ + G +++K E P S K R +E K+G ++ ++ G Sbjct: 17 TPLVKINNIDTF-GNEIYVKLEGSNPGRSTKDRIALKMIEEAEKEGLIDKDTVIIEATSG 75 Query: 74 NAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLT-GKVWDEANL-RAQELA 131 N GI A IV+P++ S++ +Q ++ G EV LT G + +A L + +EL Sbjct: 76 NTGIGLAMICAVKNYKLKIVMPDTMSIERIQLMRAYGTEVILTDGSLGMKACLEKLEELK 135 Query: 132 KRDGWENVP 140 K + VP Sbjct: 136 KNEKKYFVP 144 >5XW3-A nrPDB Length = 315 Score = 39.3 bits (90), Expect = 0.002, Method: Compositional matrix adjust. Identities = 75/304 (24%), Positives = 121/304 (39%), Gaps = 40/304 (13%) Query: 18 TPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKKGC----RHLVCSSGG 73 TP++E S G+ +F K E P GS K R ++ +KG ++ + G Sbjct: 14 TPIVEITRFSLPEGVRLFAKLEFYNPGGSVKDRLGRELIEDALEKGLVTEGGTIIEPTAG 73 Query: 74 NAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEV--QLTGKVWDEANLRAQELA 131 N GI A AA + + + +PE S++ + ++ GA V T + A +A+EL Sbjct: 74 NTGIGLALAALQHDLRVIVCVPEKFSIEKQELMKALGATVVHTPTEQGMTGAIAKAKELV 133 Query: 132 KRDGWENVPPFDHPLIWKGHA-------SLVQELKAVLRTPPGALVLAVGGGGLLAGVVA 184 +P P + A +L EL + L V G GG G + Sbjct: 134 NE-----IPNSYSPSQFANEANPRAYFKTLGPELWSALNGEINIFVAGAGTGGTFMGTAS 188 Query: 185 GLLEVGWQHVPIIAMETHGAHCFNAAITAGKLVTLPDITSVAKSLGAKTVAARALECMQV 244 L E + + +E G+ N AG T + +G + + L+ Sbjct: 189 YLKEKNID-IKTVIVEPEGS-ILNGG-KAGSHET--------EGIGLEFIPP-FLKTSYF 236 Query: 245 CKIHSEVVEDTEAVSAVQQLLDDERMLVEPACGAALAAIYSGLLRRLQAEGCLPPSLTSV 304 +IH+ + D A V++L E +LV + GAA A L+AE P T++ Sbjct: 237 DEIHT--ISDRNAFLRVKELAQKEGLLVGSSSGAAFHA------SLLEAEKAAPG--TNI 286 Query: 305 VVIV 308 V I Sbjct: 287 VTIF 290 >3PC3-A nrPDB Length = 527 Score = 38.9 bits (89), Expect = 0.003, Method: Compositional matrix adjust. Identities = 27/87 (31%), Positives = 41/87 (47%), Gaps = 4/87 (4%) Query: 34 VFLKCENVQPSGSFKIRGIGHFCQEMAKKGC----RHLVCSSGGNAGIAAAYAARKLGIP 89 ++ KCE + P GS K R Q+ ++G ++ + GN GI A A G Sbjct: 79 MYAKCEFLNPGGSVKDRIGYRMVQDAEEQGLLKPGYTIIEPTSGNTGIGLAMACAVKGYK 138 Query: 90 ATIVLPESTSLQVVQRLQGEGAEVQLT 116 IV+PE S + V L+ GA++ T Sbjct: 139 CIIVMPEKMSNEKVSALRTLGAKIIRT 165 >1M54-A nrPDB Length = 363 Score = 37.7 bits (86), Expect = 0.007, Method: Compositional matrix adjust. Identities = 51/191 (26%), Positives = 75/191 (39%), Gaps = 27/191 (14%) Query: 18 TPLLESWALSQVAGMPVFL--KCENVQPSGSFKIRGIGHFCQEMAKKGC----RHLVCSS 71 TP++ + + G+ L KCE GS K R ++ + G ++ + Sbjct: 44 TPMVRINKIGKKFGLKCELLAKCEFFNAGGSVKDRISLRMIEDAERDGTLKPGDTIIEPT 103 Query: 72 GGNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTGKVWDEANLRAQELA 131 GN GI A AA G IV+PE S + V L+ GAE+ T A + E Sbjct: 104 SGNTGIGLALAAAVRGYRCIIVMPEKMSSEKVDVLRALGAEIVRTPT---NARFDSPESH 160 Query: 132 KRDGW--ENVPPFDHPLIWKGHAS------------LVQELKAVLRTPPGALVLAVGGGG 177 W +N P H L +AS ++Q+ L LV +VG GG Sbjct: 161 VGVAWRLKNEIPNSHILDQYRNASNPLAHYDTTADEILQQCDGKL----DMLVASVGTGG 216 Query: 178 LLAGVVAGLLE 188 + G+ L E Sbjct: 217 TITGIARKLKE 227 >3T4P-A nrPDB Length = 334 Score = 37.4 bits (85), Expect = 0.010, Method: Compositional matrix adjust. Identities = 37/106 (34%), Positives = 50/106 (47%), Gaps = 10/106 (9%) Query: 18 TPLLESWALSQVAGMPVF-LKCENVQPSGSFKIRGIGHFCQEMAKK------GCRHLVCS 70 TP L L+ V ++CEN P S K R +G + A+K G +V S Sbjct: 22 TPALYLNKLNNTKAKVVLKMECEN--PMASVKDR-LGFAIYDKAEKEGKLIPGKSIVVES 78 Query: 71 SGGNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLT 116 S GN G++ A+ G I +PES SL+ L+ GAEV LT Sbjct: 79 SSGNTGVSLAHLGAIRGYKVIITMPESMSLERRCLLRIFGAEVILT 124 >1J0B-A nrPDB Length = 325 Score = 37.4 bits (85), Expect = 0.010, Method: Compositional matrix adjust. Identities = 50/188 (26%), Positives = 86/188 (45%), Gaps = 26/188 (13%) Query: 18 TPLLESWALSQVAGMPVFLKCENVQP--SGSFKIRGIGHFCQEMAKKGCRHLVCSSGG-- 73 TP+ +S+ G V++K +++ G KIR + + + KG +V + G Sbjct: 22 TPIQYLPNISREIGADVYIKRDDLTGLGIGGNKIRKLEYLLGDALSKGA-DVVITVGAVH 80 Query: 74 -NAGIAAAYAARKLGIPATIVLPESTSLQ---VVQRLQGEGAEVQLTGKVWD-----EAN 124 N AA+KLG+ A +VL L+ ++ ++ G + +V+D E Sbjct: 81 SNHAFVTGLAAKKLGLDAILVLRGKEELKGNYLLDKIMG------IETRVYDAKDSFELM 134 Query: 125 LRAQELA---KRDGWEN--VPPFD-HPLIWKGHASLVQELKAVLRTPPGALVLAVGGGGL 178 A+E+A KR+G + +PP P+ G+ V E+ ++V+A G GG Sbjct: 135 KYAEEIAEELKREGRKPYVIPPGGASPIGTLGYVRAVGEIATQSEVKFDSIVVAAGSGGT 194 Query: 179 LAGVVAGL 186 LAG+ GL Sbjct: 195 LAGLSLGL 202 >4COO-A nrPDB Length = 563 Score = 37.0 bits (84), Expect = 0.011, Method: Compositional matrix adjust. Identities = 51/191 (26%), Positives = 75/191 (39%), Gaps = 27/191 (14%) Query: 18 TPLLESWALSQVAGMPVFL--KCENVQPSGSFKIRGIGHFCQEMAKKGC----RHLVCSS 71 TP++ + + G+ L KCE GS K R ++ + G ++ + Sbjct: 109 TPMVRINKIGKKFGLKCELLAKCEFFNAGGSVKDRISLRMIEDAERDGTLKPGDTIIEPT 168 Query: 72 GGNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTGKVWDEANLRAQELA 131 GN GI A AA G IV+PE S + V L+ GAE+ T A + E Sbjct: 169 SGNTGIGLALAAAVRGYRCIIVMPEKMSSEKVDVLRALGAEIVRTPT---NARFDSPESH 225 Query: 132 KRDGW--ENVPPFDHPLIWKGHAS------------LVQELKAVLRTPPGALVLAVGGGG 177 W +N P H L +AS ++Q+ L LV +VG GG Sbjct: 226 VGVAWRLKNEIPNSHILDQYRNASNPLAHYDTTADEILQQCDGKL----DMLVASVGTGG 281 Query: 178 LLAGVVAGLLE 188 + G+ L E Sbjct: 282 TITGIARKLKE 292 >5MMS-A nrPDB Length = 408 Score = 37.0 bits (84), Expect = 0.012, Method: Compositional matrix adjust. Identities = 51/191 (26%), Positives = 75/191 (39%), Gaps = 27/191 (14%) Query: 18 TPLLESWALSQVAGMPVFL--KCENVQPSGSFKIRGIGHFCQEMAKKGC----RHLVCSS 71 TP++ + + G+ L KCE GS K R ++ + G ++ + Sbjct: 87 TPMVRINKIGKKFGLKCELLAKCEFFNAGGSVKDRISLRMIEDAERDGTLKPGDTIIEPT 146 Query: 72 GGNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTGKVWDEANLRAQELA 131 GN GI A AA G IV+PE S + V L+ GAE+ T A + E Sbjct: 147 SGNTGIGLALAAAVRGYRCIIVMPEKMSSEKVDVLRALGAEIVRTPT---NARFDSPESH 203 Query: 132 KRDGW--ENVPPFDHPLIWKGHAS------------LVQELKAVLRTPPGALVLAVGGGG 177 W +N P H L +AS ++Q+ L LV +VG GG Sbjct: 204 VGVAWRLKNEIPNSHILDQYRNASNPLAHYDTTADEILQQCDGKL----DMLVASVGTGG 259 Query: 178 LLAGVVAGLLE 188 + G+ L E Sbjct: 260 TITGIARKLKE 270 >4OFX-A nrPDB Length = 319 Score = 36.2 bits (82), Expect = 0.019, Method: Compositional matrix adjust. Identities = 32/104 (30%), Positives = 46/104 (44%), Gaps = 6/104 (5%) Query: 18 TPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKKGCR-----HLVCSSG 72 TP++ + Q ++ KCE + P GS K R IG E A+K + L+ + Sbjct: 16 TPVVRLHRIGQSLPCELYGKCEFLNPGGSVKDR-IGAAMIESAEKQGKIKPGDTLIEPTS 74 Query: 73 GNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLT 116 GN GI A A G I +PE S + L+ GA + T Sbjct: 75 GNTGIGIALAGAVKGYRVIITMPEKMSHEKQVVLEALGATIYRT 118 >2PQM-A nrPDB Length = 343 Score = 36.2 bits (82), Expect = 0.019, Method: Compositional matrix adjust. Identities = 31/108 (28%), Positives = 48/108 (44%), Gaps = 10/108 (9%) Query: 18 TPLLESWALSQ----VAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKKGCR-----HLV 68 TPL+E +++ G + +K E P S K R +G A K R ++ Sbjct: 24 TPLVELHGVTEHPRIKKGTRILVKLEYFNPMSSVKDR-VGFNIVYQAIKDGRLKPGMEII 82 Query: 69 CSSGGNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLT 116 S+ GN GIA A G I +P + S++ ++ GAE+ LT Sbjct: 83 ESTSGNTGIALCQAGAVFGYRVNIAMPSTMSVERQMIMKAFGAELILT 130 >2EFY-A nrPDB Length = 304 Score = 36.2 bits (82), Expect = 0.020, Method: Compositional matrix adjust. Identities = 25/89 (28%), Positives = 41/89 (46%), Gaps = 6/89 (6%) Query: 34 VFLKCENVQPSGSFKIRGIGHFCQEMAKKGCRH------LVCSSGGNAGIAAAYAARKLG 87 V++K E + P GS K R + ++ ++G +V + GN GI A A G Sbjct: 26 VWVKLEGLNPGGSIKDRPAWYMIKDAEERGILRPGSGQVIVEPTSGNTGIGLAMIAASRG 85 Query: 88 IPATIVLPESTSLQVVQRLQGEGAEVQLT 116 + +P S + + L+ GAE+ LT Sbjct: 86 YRLILTMPAQMSEERKRVLKAFGAELVLT 114 >5OCW-B nrPDB Length = 442 Score = 35.4 bits (80), Expect = 0.034, Method: Compositional matrix adjust. Identities = 36/103 (34%), Positives = 51/103 (49%), Gaps = 9/103 (8%) Query: 18 TPLLESWALSQVAGMP-VFLKCENVQPSGSFKIR---GIGHFCQEMAKKGCRHLVCSSGG 73 +PL E+ LSQ AG +FLK E++ +GS KI G + M K R + + G Sbjct: 102 SPLYEATRLSQHAGSARIFLKREDLNHTGSHKINNVLGQALLARRMGK--TRVIAETGAG 159 Query: 74 NAGIAAAYAARKLGIPATIVLPE-STSLQV--VQRLQGEGAEV 113 G+A A A LG+ I + T+ Q V R++ GAEV Sbjct: 160 QHGVATATACALLGLDCVIYMGGIDTARQALNVARMRLLGAEV 202 >1X1Q-A nrPDB Length = 418 Score = 34.7 bits (78), Expect = 0.053, Method: Compositional matrix adjust. Identities = 60/226 (26%), Positives = 93/226 (41%), Gaps = 32/226 (14%) Query: 18 TPLLESWALSQV-AGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKKGCRHLVCSSG-GNA 75 TPL + LS+ G VFLK E++ +G+ KI + G R ++ +G G Sbjct: 78 TPLYHAKRLSEYWGGAQVFLKREDLLHTGAHKINNTLGQALLARRMGKRRVIAETGAGQH 137 Query: 76 GIAAAYAARKLGIPATIVLPESTSLQV---VQRLQGEGAEVQLTGKVWDEANLRAQELAK 132 G++ A A G+ + + E + V R++ GAEV+ A A Sbjct: 138 GVSVATVAALFGLECVVYMGEEDVRRQALNVFRMKLLGAEVRPVA-AGSRTLKDATNEAI 196 Query: 133 RDGWENVP-----------PFDHPLIWKGHASLV------QELKAVLRTPPGALVLAVGG 175 RD NV P +P++ + S++ Q L+ R P AL+ AVGG Sbjct: 197 RDWITNVRTTFYILGSVVGPHPYPMMVRDFQSVIGEEVKRQSLELFGRLPD-ALIAAVGG 255 Query: 176 GGLLAGVVAGLLEVGWQHVPIIAME------THGAHCFNAAITAGK 215 G G+ A + +I +E + G H A+I AGK Sbjct: 256 GSNAIGLFAPFAYLPEGRPKLIGVEAAGEGLSTGRHA--ASIGAGK 299 >5B55-A nrPDB Length = 340 Score = 34.7 bits (78), Expect = 0.066, Method: Compositional matrix adjust. Identities = 33/125 (26%), Positives = 59/125 (47%), Gaps = 10/125 (8%) Query: 3 GPVAEHAKQEPF--HVV--TPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGH---- 54 GP+ K+ + ++V TP+LE + +F+K E+ +GS K R + Sbjct: 1 GPLGSEQKKMKYLENLVGKTPMLELIFDYKGEERRIFVKNESYNLTGSIKDRMAFYTLKK 60 Query: 55 -FCQEMAKKGCRHLVCSSGGNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEV 113 + + KKG +V ++ GN GIA + LG P I +P+ S + ++ GA++ Sbjct: 61 AYEKNEIKKGA-PIVEATSGNTGIAFSAMGAILGHPVIIYMPDWMSEERKSLIRSFGAKI 119 Query: 114 QLTGK 118 L + Sbjct: 120 ILVSR 124 >4AEC-A nrPDB Length = 430 Score = 32.0 bits (71), Expect = 0.35, Method: Compositional matrix adjust. Identities = 39/125 (31%), Positives = 58/125 (46%), Gaps = 12/125 (9%) Query: 37 KCENVQPSGSFKIRGIGHFCQEMAKK------GCRHLVCSSGGNAGIAAAYAARKLGIPA 90 K E ++P S K R IG+ A++ G LV + GN GI A+ A G Sbjct: 143 KLEIMEPCCSVKDR-IGYSMVTDAEQKGFISPGKSVLVEPTSGNTGIGLAFIAASRGYRL 201 Query: 91 TIVLPESTSLQVVQRLQGEGAEVQLT--GKVWDEANLRAQELAKR--DGWENVPPFDHPL 146 + +P S S++ L+ GAE+ LT K A +A+E+ K D + + FD+P Sbjct: 202 ILTMPASMSMERRVLLKAFGAELVLTDPAKGMTGAVQKAEEILKNTPDAY-MLQQFDNPA 260 Query: 147 IWKGH 151 K H Sbjct: 261 NPKIH 265 >2ISQ-A nrPDB Length = 320 Score = 31.2 bits (69), Expect = 0.71, Method: Compositional matrix adjust. Identities = 38/134 (28%), Positives = 53/134 (39%), Gaps = 20/134 (14%) Query: 37 KCENVQPSGSFKIRGIGHFCQEMAKKGCRH-----LVCSSGGNAGIAAAYAARKLGIPAT 91 K E ++P S K R + KKG L+ + GN G+ A+ A G Sbjct: 33 KLEMMEPCSSVKDRIGFSMISDAEKKGLIKPGESVLIEPTSGNTGVGLAFTAAAKGYKLI 92 Query: 92 IVLPESTSLQVVQRLQGEGAEVQLT--GKVWDEANLRAQE-LAKRDGWENVPPFDHPL-- 146 I +P S S + L G E+ LT K A +A+E LAK + F++P Sbjct: 93 ITMPASMSTERRIILLAFGVELVLTDPAKGMKGAIAKAEEILAKTPNGYMLQQFENPANP 152 Query: 147 ----------IWKG 150 IWKG Sbjct: 153 KIHYETTGPEIWKG 166 >3KYC-B nrPDB Length = 660 Score = 29.3 bits (64), Expect = 2.5, Method: Compositional matrix adjust. Identities = 13/42 (30%), Positives = 22/42 (52%) Query: 167 GALVLAVGGGGLLAGVVAGLLEVGWQHVPIIAMETHGAHCFN 208 G VL VG GG+ ++ L+ G+ H+ +I ++T N Sbjct: 37 GGRVLVVGAGGIGCELLKNLVLTGFSHIDLIDLDTIDVSNLN 78 >3KYD-B nrPDB Length = 551 Score = 28.9 bits (63), Expect = 3.0, Method: Compositional matrix adjust. Identities = 13/42 (30%), Positives = 22/42 (52%) Query: 167 GALVLAVGGGGLLAGVVAGLLEVGWQHVPIIAMETHGAHCFN 208 G VL VG GG+ ++ L+ G+ H+ +I ++T N Sbjct: 19 GGRVLVVGAGGIGCELLKNLVLTGFSHIDLIDLDTIDVSNLN 60 >6CNV-B nrPDB Length = 220 Score = 28.9 bits (63), Expect = 3.0, Method: Compositional matrix adjust. Identities = 25/89 (28%), Positives = 45/89 (50%), Gaps = 11/89 (12%) Query: 181 GVVAGLLEVGWQHVPIIA----METHGAHCFNAAITAGKLVTLPDITSVAKSLGA-KTVA 235 G +AG LE GW+ +IA +HGAH A+ A T I + K+L + + Sbjct: 4 GAIAGFLEGGWE--GMIAGWHGYTSHGAH--GVAVAADLKSTQEAINKITKNLNSLSELE 59 Query: 236 ARALECMQ--VCKIHSEVVEDTEAVSAVQ 262 + L+ + + ++H+E++E E V ++ Sbjct: 60 VKNLQRLSGAMDELHNEILELDEKVDDLR 88 >4M40-B nrPDB Length = 182 Score = 28.5 bits (62), Expect = 4.0, Method: Compositional matrix adjust. Identities = 25/89 (28%), Positives = 45/89 (50%), Gaps = 11/89 (12%) Query: 181 GVVAGLLEVGWQHVPIIA----METHGAHCFNAAITAGKLVTLPDITSVAKSLGA-KTVA 235 G +AG LE GW+ +IA +HGAH A+ A T I + K+L + + Sbjct: 4 GAIAGFLEGGWE--GMIAGWHGYTSHGAH--GVAVAADLKSTQEAINKITKNLNSLSELE 59 Query: 236 ARALECMQ--VCKIHSEVVEDTEAVSAVQ 262 + L+ + + ++H+E++E E V ++ Sbjct: 60 VKNLQRLSGAMDELHNEILELDEKVDDLR 88 >1UJN-A nrPDB Length = 348 Score = 28.1 bits (61), Expect = 5.5, Method: Compositional matrix adjust. Identities = 21/62 (33%), Positives = 29/62 (46%), Gaps = 1/62 (1%) Query: 43 PSGSFKIRGIGHFCQEMAKK-GCRHLVCSSGGNAGIAAAYAARKLGIPATIVLPESTSLQ 101 P+ R + F QE+AK G RHL+ GG A + + L A LP + +L Sbjct: 30 PAALLFDRRVEGFAQEVAKALGVRHLLGLPGGEAAKSLEVYGKVLSWLAEKGLPRNATLL 89 Query: 102 VV 103 VV Sbjct: 90 VV 91 >4WBT-A nrPDB Length = 376 Score = 27.3 bits (59), Expect = 8.5, Method: Compositional matrix adjust. Identities = 24/88 (27%), Positives = 40/88 (45%), Gaps = 12/88 (13%) Query: 134 DGWENVPPFDHPLIWKGHASLVQELKAVLRTPPGALVLAVGGGGLLAGVVAGLLEVGWQH 193 D W+ P +H L Q L L T P + + G GLL +V ++E G Sbjct: 64 DTWKYADPENH--------DLKQALARHLGTSPANIAIGEGIDGLLGQIVRLVVEAG--- 112 Query: 194 VPII-AMETHGAHCFNAAITAGKLVTLP 220 P++ ++ + ++ A G+LVT+P Sbjct: 113 APVVTSLGGYPTFNYHVAGHGGRLVTVP 140 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 2RKB-A nrPDB 392 e-109 1PWH-A nrPDB 331 3e-91 4H27-A nrPDB 322 2e-88 5C3U-A nrPDB 295 1e-80 6NMX-A nrPDB 259 1e-69 2D1F-A nrPDB 258 2e-69 1TDJ-A nrPDB 252 1e-67 5X2L-A nrPDB 252 1e-67 2ZSJ-A nrPDB 242 2e-64 5CVC-A nrPDB 237 5e-63 5JJC-A nrPDB 235 2e-62 3IAU-A nrPDB 232 2e-61 3L6C-A nrPDB 231 2e-61 1UIN-A nrPDB 231 3e-61 3FCA-A nrPDB 220 5e-58 6C2H-A nrPDB 215 3e-56 5YBW-A nrPDB 212 2e-55 1V71-A nrPDB 209 2e-54 6AHI-A nrPDB 208 2e-54 5D84-A nrPDB 206 1e-53 5XA2-A nrPDB 203 9e-53 5OHX-A nrPDB 197 7e-51 2GN1-A nrPDB 196 8e-51 2BHS-A nrPDB 193 6e-50 2JC3-A nrPDB 192 2e-49 2Q3D-A nrPDB 191 2e-49 5J5V-A nrPDB 187 7e-48 1VE5-A nrPDB 186 9e-48 5XEM-A nrPDB 184 6e-47 4I1Y-A nrPDB 183 6e-47 2EGU-A nrPDB 182 2e-46 4LMA-A nrPDB 181 5e-46 3VBE-A nrPDB 180 6e-46 5B1I-A nrPDB 173 1e-43 4LMB-A nrPDB 169 2e-42 3X43-A nrPDB 161 6e-40 5XCN-X nrPDB 160 7e-40 4D9G-A nrPDB 158 3e-39 5I7O-A nrPDB 149 2e-36 5YGR-A nrPDB 143 8e-35 Sequences not found previously or not previously below threshold: 1M54-A nrPDB 201 3e-52 4COO-A nrPDB 201 3e-52 5MMS-A nrPDB 200 7e-52 5XW3-A nrPDB 187 7e-48 2EFY-A nrPDB 181 3e-46 4OFX-A nrPDB 178 3e-45 3PC3-A nrPDB 176 9e-45 4AEC-A nrPDB 173 1e-43 2ISQ-A nrPDB 169 2e-42 2PQM-A nrPDB 156 1e-38 3T4P-A nrPDB 146 1e-35 5B55-A nrPDB 142 2e-34 1E5X-A nrPDB 135 3e-32 3VSD-A nrPDB 100 1e-21 5EY5-B nrPDB 94 5e-20 5OCW-B nrPDB 92 3e-19 5KIN-B nrPDB 91 5e-19 6HUL-B nrPDB 89 2e-18 6AMI-A nrPDB 88 7e-18 4D9F-A nrPDB 87 1e-17 4NEG-A nrPDB 87 1e-17 1X1Q-A nrPDB 85 5e-17 5KZM-B nrPDB 84 6e-17 3SS9-X nrPDB 81 5e-16 1CX9-B nrPDB 81 9e-16 3R0X-A nrPDB 78 4e-15 1RQX-A nrPDB 75 5e-14 1J0B-A nrPDB 72 3e-13 6EQN-B nrPDB 69 3e-12 1VB3-A nrPDB 59 3e-09 2VCY-A nrPDB 34 0.10 2KU2-A nrPDB 31 0.54 1T8T-A nrPDB 31 0.71 1G5T-A nrPDB 30 1.2 1FGS-A nrPDB 30 1.5 3UI2-A nrPDB 29 3.0 3DEO-A nrPDB 29 3.0 1V6S-A nrPDB 29 3.7 4RVS-A nrPDB 29 3.8 6DV6-A nrPDB 29 4.2 4MUZ-A nrPDB 28 4.6 2PNF-A nrPDB 28 5.0 1ZOS-A nrPDB 28 5.6 5C8D-A nrPDB 28 7.1 6OMZ-A nrPDB 27 8.2 5C8A-A nrPDB 27 8.6 >2RKB-A nrPDB Length = 318 Score = 392 bits (1006), Expect = e-109, Method: Composition-based stats. Identities = 318/318 (100%), Positives = 318/318 (100%) Query: 11 QEPFHVVTPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKKGCRHLVCS 70 QEPFHVVTPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKKGCRHLVCS Sbjct: 1 QEPFHVVTPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKKGCRHLVCS 60 Query: 71 SGGNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTGKVWDEANLRAQEL 130 SGGNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTGKVWDEANLRAQEL Sbjct: 61 SGGNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTGKVWDEANLRAQEL 120 Query: 131 AKRDGWENVPPFDHPLIWKGHASLVQELKAVLRTPPGALVLAVGGGGLLAGVVAGLLEVG 190 AKRDGWENVPPFDHPLIWKGHASLVQELKAVLRTPPGALVLAVGGGGLLAGVVAGLLEVG Sbjct: 121 AKRDGWENVPPFDHPLIWKGHASLVQELKAVLRTPPGALVLAVGGGGLLAGVVAGLLEVG 180 Query: 191 WQHVPIIAMETHGAHCFNAAITAGKLVTLPDITSVAKSLGAKTVAARALECMQVCKIHSE 250 WQHVPIIAMETHGAHCFNAAITAGKLVTLPDITSVAKSLGAKTVAARALECMQVCKIHSE Sbjct: 181 WQHVPIIAMETHGAHCFNAAITAGKLVTLPDITSVAKSLGAKTVAARALECMQVCKIHSE 240 Query: 251 VVEDTEAVSAVQQLLDDERMLVEPACGAALAAIYSGLLRRLQAEGCLPPSLTSVVVIVCG 310 VVEDTEAVSAVQQLLDDERMLVEPACGAALAAIYSGLLRRLQAEGCLPPSLTSVVVIVCG Sbjct: 241 VVEDTEAVSAVQQLLDDERMLVEPACGAALAAIYSGLLRRLQAEGCLPPSLTSVVVIVCG 300 Query: 311 GNNINSRELQALKTHLGQ 328 GNNINSRELQALKTHLGQ Sbjct: 301 GNNINSRELQALKTHLGQ 318 >1PWH-A nrPDB Length = 327 Score = 331 bits (848), Expect = 3e-91, Method: Composition-based stats. Identities = 197/320 (61%), Positives = 244/320 (76%), Gaps = 1/320 (0%) Query: 9 AKQEPFHVVTPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKKGCRHLV 68 A QE HV TPL +S ALS+VAG VFLK ++ QPSGSFKIRGIGH C+ AK+GC+H V Sbjct: 2 AAQESLHVKTPLRDSMALSKVAGTSVFLKMDSSQPSGSFKIRGIGHLCKMKAKQGCKHFV 61 Query: 69 CSSGGNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTGKVWDEANLRAQ 128 CSS GNAG+A AYAAR+LG+PATIV+P +T ++RL+ EGA V++ G++ DEA A+ Sbjct: 62 CSSAGNAGMATAYAARRLGLPATIVVPSTTPALTIERLKNEGATVEVVGEMLDEAIQLAK 121 Query: 129 ELAKRD-GWENVPPFDHPLIWKGHASLVQELKAVLRTPPGALVLAVGGGGLLAGVVAGLL 187 L K + GW + PFD PLIW+GH SLV+ELK L PGA+VL+VGGGGLL GVV GL Sbjct: 122 ALEKNNPGWVYISPFDDPLIWEGHTSLVKELKETLSAKPGAIVLSVGGGGLLCGVVQGLR 181 Query: 188 EVGWQHVPIIAMETHGAHCFNAAITAGKLVTLPDITSVAKSLGAKTVAARALECMQVCKI 247 EVGW+ VPIIAMET GAH F+AA+ GKLVTLP ITSVAK+LG TV A+ L+ I Sbjct: 182 EVGWEDVPIIAMETFGAHSFHAAVKEGKLVTLPKITSVAKALGVNTVGAQTLKLFYEHPI 241 Query: 248 HSEVVEDTEAVSAVQQLLDDERMLVEPACGAALAAIYSGLLRRLQAEGCLPPSLTSVVVI 307 SEV+ D EAV+A+++ +DDE++LVEPACGAALAA+YSG++ RLQAE L L S+VVI Sbjct: 242 FSEVISDQEAVTAIEKFVDDEKILVEPACGAALAAVYSGVVCRLQAEARLQTPLASLVVI 301 Query: 308 VCGGNNINSRELQALKTHLG 327 VCGG+NI+ +LQALK LG Sbjct: 302 VCGGSNISLAQLQALKAQLG 321 >4H27-A nrPDB Length = 364 Score = 322 bits (824), Expect = 2e-88, Method: Composition-based stats. Identities = 196/317 (61%), Positives = 249/317 (78%), Gaps = 1/317 (0%) Query: 12 EPFHVVTPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKKGCRHLVCSS 71 EP HV TP+ +S ALS++AG V+LK ++ QPSGSFKIRGIGHFC+ AK+GC H VCSS Sbjct: 41 EPLHVKTPIRDSMALSKMAGTSVYLKMDSAQPSGSFKIRGIGHFCKRWAKQGCAHFVCSS 100 Query: 72 GGNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTGKVWDEANLRAQELA 131 GNAG+AAAYAAR+LG+PATIV+P +T ++RL+ EGA V++ G++ DEA A+ LA Sbjct: 101 SGNAGMAAAYAARQLGVPATIVVPGTTPALTIERLKNEGATVKVVGELLDEAFELAKALA 160 Query: 132 KRD-GWENVPPFDHPLIWKGHASLVQELKAVLRTPPGALVLAVGGGGLLAGVVAGLLEVG 190 K + GW +PPFD PLIW+GHAS+V+ELK L PGA+ L+VGGGGLL GVV GL EVG Sbjct: 161 KNNPGWVYIPPFDDPLIWEGHASIVKELKETLWEKPGAIALSVGGGGLLCGVVQGLQEVG 220 Query: 191 WQHVPIIAMETHGAHCFNAAITAGKLVTLPDITSVAKSLGAKTVAARALECMQVCKIHSE 250 W VP+IAMET GAH F+AA TAGKLV+LP ITSVAK+LG KTV A+AL+ Q I SE Sbjct: 221 WGDVPVIAMETFGAHSFHAATTAGKLVSLPKITSVAKALGVKTVGAQALKLFQEHPIFSE 280 Query: 251 VVEDTEAVSAVQQLLDDERMLVEPACGAALAAIYSGLLRRLQAEGCLPPSLTSVVVIVCG 310 V+ D EAV+A+++ +DDE++LVEPACGAALAA+YS ++++LQ EG L L S+VVIVCG Sbjct: 281 VISDQEAVAAIEKFVDDEKILVEPACGAALAAVYSHVIQKLQLEGNLRTPLPSLVVIVCG 340 Query: 311 GNNINSRELQALKTHLG 327 G+NI+ +L+ALK LG Sbjct: 341 GSNISLAQLRALKEQLG 357 >5C3U-A nrPDB Length = 366 Score = 295 bits (756), Expect = 1e-80, Method: Composition-based stats. Identities = 129/317 (40%), Positives = 196/317 (61%), Gaps = 7/317 (2%) Query: 12 EPFHVVTPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAK-KGCR-HLVC 69 + HV TPLL + L++ VFLK EN+QPSGS K+RGIG FC + + +G VC Sbjct: 16 QSLHVATPLLHAPNLTKELECNVFLKMENIQPSGSVKMRGIGAFCYQAVQTRGTNIQFVC 75 Query: 70 SSGGNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTGKVWDEANLRAQE 129 SG N +A +Y AR+LG+ A IV+P++T+ ++ Q ++ +G+ + L G+ W A + A++ Sbjct: 76 GSGPNTVLAVSYCARQLGVEAIIVVPKATNERICQSIRTDGSHLILYGENWTAAEVHARK 135 Query: 130 LAKRDGWENVPPFDHPLIWKGHASLVQELKAVLRT-PPGALVLAVGGGGLLAGVVAGLLE 188 L +R+G VP DH LIW+GH+++VQELK L PP A++ VGGGGLL GV+ GL E Sbjct: 136 LVRRNGIY-VPSSDHALIWQGHSTIVQELKTQLNDNPPAAIICPVGGGGLLNGVIMGLQE 194 Query: 189 VGWQHVPIIAMETHGAHCFNAAITAGKLVTLPDITSVAKSLGAKTVAARALECMQVCKIH 248 W+ VP+IA+ETHG++ F A++ AG+LV + ++A SL +K V++++LE + Sbjct: 195 ADWKDVPVIAVETHGSNAFQASVVAGELVIMEKNNTIATSLISKAVSSKSLELSLNHPVV 254 Query: 249 SEVVEDTEAVSAVQQLLDDERMLVEPACGAALAAIYSGLLRRLQAEGCLPPSLTSVVVIV 308 V D A AV+ +D +MLVE + GAAL+ Y+ L+R + VVV+V Sbjct: 255 PFAVSDAMAADAVRLFAEDFKMLVEASAGAALSLCYTHLIRDIL---PSLSPAKDVVVLV 311 Query: 309 CGGNNINSRELQALKTH 325 GG++I+ L + Sbjct: 312 TGGSDISLAHLDEYRKK 328 >6NMX-A nrPDB Length = 354 Score = 259 bits (661), Expect = 1e-69, Method: Composition-based stats. Identities = 72/320 (22%), Positives = 133/320 (41%), Gaps = 18/320 (5%) Query: 4 PVAEHAKQEPFHV-VTPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKK 62 PV + H TPL+ LS+ G+ + +K E V P+GSFK RG+ + ++ Sbjct: 16 PVTDQTPALTLHEGNTPLIHLPKLSEQLGIELHVKTEGVNPTGSFKDRGMVMAVAKAKEE 75 Query: 63 GCRHLVCSSGGNAGIAAAYAARKLGIPATIVLPES-TSLQVVQRLQGEGAEVQLTGKVWD 121 G ++C+S GN AAA A + + +++P + + + GAE+ +D Sbjct: 76 GNDTIMCASTGNTSAAAAAYAARANMKCIVIIPNGKIAFGKLAQAVMYGAEIIAIDGNFD 135 Query: 122 EANLRAQELAKRDGWENVPPFDHPLIWKGHASLVQELKAVLRTPPGALVLAVGGGGLLAG 181 +A + + ++ V +P +G + E+ L P L + VG G ++ Sbjct: 136 DALKIVRSICEKSPIALVNSV-NPYRLEGQKTAAFEVCEQLGEAPDVLAIPVGNAGNISA 194 Query: 182 VVAGLLEVGWQH----VPIIAMETHGAHCFNAAITAGKLVTLPDITSVAKSLGAKTVAAR 237 G E ++ + E G+ AAI +++ P+ + A +G + Sbjct: 195 YWKGFKEYHEKNGTSLPKMRGFEAEGS----AAIVRNEVIENPETIATAIRIGNPASWDK 250 Query: 238 ALECMQVCKIHSEVVEDTEAVSAVQQLLDDERMLVEPACGAALAAIYSGLLRRLQAEGCL 297 A++ + + V D E + A Q + +E + EP A++A + + G + Sbjct: 251 AVKAAEESNGKIDEVTDDEILHAYQLIAREEGVFAEPGSCASIAGVLKQV-----KSGEI 305 Query: 298 PPSLTSVVVIVCGGNNINSR 317 P VV V GN + Sbjct: 306 PKGSK--VVAVLTGNGLKDP 323 >2D1F-A nrPDB Length = 360 Score = 258 bits (659), Expect = 2e-69, Method: Composition-based stats. Identities = 78/308 (25%), Positives = 133/308 (43%), Gaps = 10/308 (3%) Query: 18 TPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKKGCRHLVCSSGGNAGI 77 TPL+ + LS+ G + LK E + P+GSFK RG+ + G R ++C+S GN Sbjct: 39 TPLIAATNLSKQTGCTIHLKVEGLNPTGSFKDRGMTMAVTDALAHGQRAVLCASTGNTSA 98 Query: 78 AAAYAARKLGIPATIVLPES-TSLQVVQRLQGEGAEVQLTGKVWDEANLRAQELAKRDGW 136 +AA A + GI +++P+ ++ + + GA++ +D+ A+++A Sbjct: 99 SAAAYAARAGITCAVLIPQGKIAMGKLAQAVMHGAKIIQIDGNFDDCLELARKMAADFPT 158 Query: 137 ENVPPFDHPLIWKGHASLVQELKAVLRTPPGALVLAVGGGGLLAGVVAGLLEVGWQHVPI 196 ++ +P+ +G + E+ VL T P L VG G + G E + Sbjct: 159 ISLVNSVNPVRIEGQKTAAFEIVDVLGTAPDVHALPVGNAGNITAYWKGYTEYHQLGLID 218 Query: 197 IAMETHGAHCFNAA-ITAGKLVTLPDITSVAKSLGAKTVAARALECMQVCKIHSEVVEDT 255 G AA + G+ V+ P+ + A +G+ A+E Q K D Sbjct: 219 KLPRMLGTQAAGAAPLVLGEPVSHPETIATAIRIGSPASWTSAVEAQQQSKGRFLAASDE 278 Query: 256 EAVSAVQQLLDDERMLVEPACGAALAAIYSGLLRRLQAEGCLPPSLTSVVVIVCGGNNIN 315 E ++A + E + VEPA A++A + + A G S VV GN + Sbjct: 279 EILAAYHLVARVEGVFVEPASAASIAGLLKAIDDGWVARG-------STVVCTVTGNGLK 331 Query: 316 SRELQALK 323 + ALK Sbjct: 332 DPD-TALK 338 >1TDJ-A nrPDB Length = 514 Score = 252 bits (644), Expect = 1e-67, Method: Composition-based stats. Identities = 89/288 (30%), Positives = 141/288 (48%), Gaps = 9/288 (3%) Query: 1 MDGPVAEHAKQEPFHVVTPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMA 60 + PV E A+ VTPL + LS + +K E+ QP SFK+RG + Sbjct: 21 LRAPVYEAAQ------VTPLQKMEKLSSRLDNVILVKREDRQPVHSFKLRGAYAMMAGLT 74 Query: 61 KKGCRH-LVCSSGGNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTGKV 119 ++ H ++ +S GN A+++ +LG+ A IV+P +T+ V ++G G EV L G Sbjct: 75 EEQKAHGVITASAGNHAQGVAFSSARLGVKALIVMPTATADIKVDAVRGFGGEVLLHGAN 134 Query: 120 WDEANLRAQELAKRDGWENVPPFDHPLIWKGHASLVQELKAVLRTPPGALVLAVGGGGLL 179 +DEA +A EL+++ G+ VPPFDHP++ G +L EL V GGG L Sbjct: 135 FDEAKAKAIELSQQQGFTWVPPFDHPMVIAGQGTLALELLQQ--DAHLDRVFVPVGGGGL 192 Query: 180 AGVVAGLLEVGWQHVPIIAMETHGAHCFNAAITAGKLVTLPDITSVAKSLGAKTVAARAL 239 A VA L++ + +IA+E + C AA+ AG V LP + A+ + K + Sbjct: 193 AAGVAVLIKQLMPQIKVIAVEAEDSACLKAALDAGHPVDLPRVGLFAEGVAVKRIGDETF 252 Query: 240 ECMQVCKIHSEVVEDTEAVSAVQQLLDDERMLVEPACGAALAAIYSGL 287 Q V+ +A++ L +D R + EP+ ALA + + Sbjct: 253 RLCQEYLDDIITVDSDAICAAMKDLFEDVRAVAEPSGALALAGMKKYI 300 >5X2L-A nrPDB Length = 348 Score = 252 bits (644), Expect = 1e-67, Method: Composition-based stats. Identities = 80/314 (25%), Positives = 143/314 (45%), Gaps = 14/314 (4%) Query: 16 VVTPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGH----FCQEMAKKGCRHLVCSS 71 +TP+L S L+Q+ G +F KCE Q +GSFKIRG + + ++ + +V S Sbjct: 24 HLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVRSLVPDALERKPKAVVTHS 83 Query: 72 GGNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTGKVWDEANLRAQELA 131 GN G A YAA+ GIPA IV+P++ +Q GA + + A+ + Sbjct: 84 SGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYCEPSDESRENVAKRVT 143 Query: 132 KRDGWENVPPFDHPLIWKGHASLVQELKAVLRTPPGALVLAVGGGGLLAGVVAGLLEVGW 191 + V P P + G ++ E+ + ALV+ VGGGG+LAG+ A ++ Sbjct: 144 EETEGIMVHPNQEPAVIAGQGTIALEVLNQVPLV-DALVVPVGGGGMLAGI-AITVKALK 201 Query: 192 QHVPIIAMETHGA-HCFNAAITAGKLVTLPDITSVAKSLGAKTVAARALECMQVCKIHSE 250 V + A E A C+ + + + L ++A + + ++ ++ Sbjct: 202 PSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGVKS-SIGLNTWPIIRDLVDDIF 260 Query: 251 VVEDTEAVSAVQQLLDDERMLVEPACGAALAAIYSGLLRRLQAEGCLPPSLTSVVVIVCG 310 V + E A Q + + ++L+EP G +AA+ S Q + P + ++ +++ G Sbjct: 261 TVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLS------QHFQTVSPEVKNICIVLSG 314 Query: 311 GNNINSRELQALKT 324 GN + + +K Sbjct: 315 GNVDLTSSITWVKQ 328 >2ZSJ-A nrPDB Length = 352 Score = 242 bits (617), Expect = 2e-64, Method: Composition-based stats. Identities = 75/321 (23%), Positives = 134/321 (41%), Gaps = 15/321 (4%) Query: 4 PVAEHAKQEPFHV-VTPLLESWALSQVAG--MPVFLKCENVQPSGSFKIRGIGHFCQEMA 60 PV E+ + TPL+E+ L++ G ++LK E + P+GSFK RG+ + Sbjct: 16 PVDENTPIVTLYEGNTPLIEADNLARAIGFKGKIYLKYEGLNPTGSFKDRGMTLAISKAV 75 Query: 61 KKGCRHLVCSSGGNAGIAAAYAARKLGIPATIVLPEST-SLQVVQRLQGEGAEVQLTGKV 119 + G R ++C+S GN +AA A + G+ A ++LP+ ++ + + GA+V Sbjct: 76 EAGKRAVICASTGNTSASAAAYAARAGLRAYVLLPKGAVAIGKLSQAMIYGAKVLAIQGT 135 Query: 120 WDEANLRAQELAKRDGWENVPPFDHPLIWKGHASLVQELKAVLRTPPGALVLAVGGGGLL 179 +D+A +++ + E V +P +G + E+ L P + VG G + Sbjct: 136 FDDALNIVRKIGENFPVEIVNSV-NPYRIEGQKTAAFEICDTLGEAPDYHFIPVGNAGNI 194 Query: 180 AGVVAGLLEVGWQHVPIIAM-ETHGAHCFNAA-ITAGKLVTLPDITSVAKSLGAKTVAAR 237 G + ++ I + G AA I G + P + A +G Sbjct: 195 TAYWKGFK-IYYEEGKITKLPRMMGWQAEGAAPIVKGYPIKNPQTIATAIKIGNPYSWKS 253 Query: 238 ALECMQVCKIHSEVVEDTEAVSAVQQLLDDERMLVEPACGAALAAIYSGLLRRLQAEGCL 297 AL+ Q + V D+E + A + + E + EPA A++A + + G Sbjct: 254 ALKAAQESGGKIDAVSDSEILYAYKLIASTEGVFCEPASAASVAGLIKLVREGFFKGGE- 312 Query: 298 PPSLTSVVVIVCGGNNINSRE 318 VV GN + + Sbjct: 313 ------VVTCTLTGNGLKDPD 327 >5CVC-A nrPDB Length = 346 Score = 237 bits (604), Expect = 5e-63, Method: Composition-based stats. Identities = 81/320 (25%), Positives = 145/320 (45%), Gaps = 8/320 (2%) Query: 8 HAKQEPFHVVTPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKKG-CRH 66 A+ P+ TP++ S ++ + G +F KCE Q +G+FKIRG + + + + Sbjct: 27 QARIAPYVHRTPVMSSTSIDAMVGKKLFFKCECFQKAGAFKIRGASNSIFALDDEQVSKG 86 Query: 67 LVCSSGGNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTGKVWDEANLR 126 +V S GN A A AA+ GIPA IV+P + V+ ++ G + + + Sbjct: 87 VVTHSSGNHAAAVALAAKLRGIPAHIVIPRNAPASKVENVKCYGGHIIWSDASIESREYV 146 Query: 127 AQELAKRDGWENVPPFDHPLIWKGHASLVQELKAVLRTPPGALVLAVGGGGLLAGVVAGL 186 ++ + + G + P + G ++ EL + +++ + GGGL++GV Sbjct: 147 SKRVQEETGAVLIHPINSKYTISGQGTVSLELLEQVPE-IDTIIVPISGGGLISGVALAA 205 Query: 187 LEVGWQHVPIIAMETHGAHCFNAAITAGKLVTLPDITSVAKSLGAKTVAARALECMQVCK 246 + + I+A E GA + AGK++TLP ++A L A + ++ Sbjct: 206 KAIN-PSIRILAAEPKGADDSAQSKAAGKIITLPSTNTIADGLRA-FLGDLTWPVVRDLV 263 Query: 247 IHSEVVEDTEAVSAVQQLLDDERMLVEPACGAALAAIYSGLLRRLQAEGCLPPSLTSVVV 306 VV+DT V A++ + ++ VEP+ LAA S ++ A + + + Sbjct: 264 DDVIVVDDTAIVDAMKMCYEILKVAVEPSGAIGLAAALSDEFKQSSAW----HESSKIGI 319 Query: 307 IVCGGNNINSRELQALKTHL 326 IV GGN Q++ HL Sbjct: 320 IVSGGNVDLGTLWQSMYKHL 339 >5JJC-A nrPDB Length = 342 Score = 235 bits (599), Expect = 2e-62, Method: Composition-based stats. Identities = 83/318 (26%), Positives = 135/318 (42%), Gaps = 29/318 (9%) Query: 18 TPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKKGCRH----LVCSSGG 73 TPL+ S++ G ++ K E + P S K R + ++ K+G +V + G Sbjct: 12 TPLIRLSKASELTGCDIYGKAEFLNPGQSVKDRAALYIIRDAEKRGLLRPGGVIVEGTAG 71 Query: 74 NAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTG----KVWDEANLRAQE 129 N GI A+ LG IV+PE+ S + L+ GAE+ + + A + Sbjct: 72 NTGIGLTMVAKALGYRTAIVIPETASQEKKDALRLLGAELIEVPAAPYRNPNNAVRLSGR 131 Query: 130 LAKR------DGWENVPPFDHPLIWKGH-ASLVQELKAVLRTPPGALVLAVGGGGLLAGV 182 LA++ +G FD+ + + H + QE+ V AVG GG LAG Sbjct: 132 LAEQLAKTEPNGAIWANQFDNTVNRQAHIETTAQEIWRDTSDQIDGFVAAVGSGGTLAGT 191 Query: 183 VAGLLEVGWQHVPIIAMETHGAHCFNAAITAGKLVTLPDITSVAKSLGAKTVAARALECM 242 GL E ++ I + HGA +A T G+L D S+ + +G + A LE Sbjct: 192 AIGLKERN-HNIKIALADPHGA-ALHAFYTTGELKAEGD--SITEGIGQGRITAN-LEGF 246 Query: 243 QVCKIHSEVVEDTEAVSAVQQLLDDERMLVEPACGAALAAIYSGLLRRLQAEGCLPPSLT 302 S + D EA+ + L+++E + + + G +A G +R + G P T Sbjct: 247 --TPDFSYQIPDAEALDILFALVEEEGLCLGGSSGINIA----GAIRLAKDLG---PGHT 297 Query: 303 SVVVIVCGGNNINSRELQ 320 V V+ GN S+ Sbjct: 298 IVTVLCDYGNRYQSKLFN 315 >3IAU-A nrPDB Length = 366 Score = 232 bits (591), Expect = 2e-61, Method: Composition-based stats. Identities = 75/276 (27%), Positives = 137/276 (49%), Gaps = 9/276 (3%) Query: 1 MDGPVAEHAKQEPFHVVTPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMA 60 + PV + A + +PL + LS G+ ++K E+ Q SFK+RG + ++ Sbjct: 50 LASPVYDVA------IESPLELAEKLSDRLGVNFYIKREDKQRVFSFKLRGAYNMMSNLS 103 Query: 61 KKGC-RHLVCSSGGNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTGKV 119 ++ + ++ +S GN A A ++L A IV+P +T + ++ G +V L GK Sbjct: 104 REELDKGVITASAGNHAQGVALAGQRLNCVAKIVMPTTTPQIKIDAVRALGGDVVLYGKT 163 Query: 120 WDEANLRAQELAKRDGWENVPPFDHPLIWKGHASLVQELKAVLRTPPGALVLAVGGGGLL 179 +DEA A EL+++DG + +PPFD P + KG ++ E+ L+ A+ + VGGGGL+ Sbjct: 164 FDEAQTHALELSEKDGLKYIPPFDDPGVIKGQGTIGTEINRQLKD-IHAVFIPVGGGGLI 222 Query: 180 AGVVAGLLEVGWQHVPIIAMETHGAHCFNAAITAGKLVTLPDITSVAKSLGAKTVAARAL 239 AGV ++ + II +E +GA ++ G V L ++ + A + V Sbjct: 223 AGVATFFKQI-APNTKIIGVEPYGAASMTLSLHEGHRVKLSNVDTFADGVAVALVGEYTF 281 Query: 240 ECMQVCKIHSEVVEDTEAVSAVQQLLDDERMLVEPA 275 Q +V + +A++ + D+ R ++E + Sbjct: 282 AKCQELIDGMVLVANDGISAAIKDVYDEGRNILETS 317 >3L6C-A nrPDB Length = 339 Score = 231 bits (590), Expect = 2e-61, Method: Composition-based stats. Identities = 77/313 (24%), Positives = 137/313 (43%), Gaps = 15/313 (4%) Query: 11 QEPFHVVTPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGH----FCQEMAKKGCRH 66 Q+ H+ TP+L S L+Q+AG +F KCE Q +GSFKIRG + + + + Sbjct: 20 QDSVHL-TPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLIPDTLEGKPKA 78 Query: 67 LVCSSGGNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTGKVWDEANLR 126 +V S GN G A YAA+ GIPA IV+P++ +Q GA + + + Sbjct: 79 VVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIVYSEPSDESRENV 138 Query: 127 AQELAKRDGWENVPPFDHPLIWKGHASLVQELKAVLRTPPGALVLAVGGGGLLAGVVAGL 186 AQ + + V P P + G ++ E+ + P ++ GGG + +A Sbjct: 139 AQRIIQETEGILVHPNQEPAVIAGQGTIALEVLNQV--PLVDALVVPVGGGGMVAGIAIT 196 Query: 187 LEVGWQHVPIIAMETHGA-HCFNAAITAGKLVTLPDITSVAKSLGAKTVAARALECMQVC 245 ++ V + A E A C+ + + L ++A + + ++ ++ Sbjct: 197 IKTLKPSVKVYAAEPSNADDCYQSKLKGELTPNLHPPETIADGVKS-SIGLNTWPIIRDL 255 Query: 246 KIHSEVVEDTEAVSAVQQLLDDERMLVEPACGAALAAIYSGLLRRLQAEGCLPPSLTSVV 305 V + E A Q + + ++L+EP G LAA+ S Q + P + ++ Sbjct: 256 VDDVFTVTEDEIKYATQLVWERMKLLIEPTAGVGLAAVLS------QHFQTVSPEVKNIC 309 Query: 306 VIVCGGNNINSRE 318 +++ GGN + Sbjct: 310 IVLSGGNVDLTSL 322 >1UIN-A nrPDB Length = 351 Score = 231 bits (590), Expect = 3e-61, Method: Composition-based stats. Identities = 82/329 (24%), Positives = 130/329 (39%), Gaps = 27/329 (8%) Query: 1 MDGPVAEHAKQE-PFHVVTPLLES------------WALSQVAGMPVFLKCENVQPSGSF 47 M P+ E + P TP++ ++ G+ ++ K E + P+GSF Sbjct: 1 MRPPLIERYRNLLPVSEKTPVISLLEGSTPLIPLKGPEEARKKGIRLYAKYEGLNPTGSF 60 Query: 48 KIRGIGHFCQEMAKKGCRHLVCSSGGNAGIAAAYAARKLGIPATIVLPEST-SLQVVQRL 106 K RG+ + + G + + C+S GN +AA A + GI A +VLP +L V + Sbjct: 61 KDRGMTLAVSKAVEGGAQAVACASTGNTAASAAAYAARAGILAIVVLPAGYVALGKVAQS 120 Query: 107 QGEGAEVQLTGKVWDEANLRAQELAKRDGWENVPPFDHPLIWKGHASLVQELKAVLRTPP 166 GA + +D+A Q+L + V +P +G +L E+ L P Sbjct: 121 LVHGARIVQVEGNFDDALRLTQKLTEAFPVALVNSV-NPHRLEGQKTLAFEVVDELGDAP 179 Query: 167 GALVLAVGGGGLLAGVVAGLLEVGWQHVPIIAMETHGAHCFNAA----ITAGKLVTLPDI 222 L VG G + G H A F AA + G+ V P+ Sbjct: 180 HYHALPVGNAGNITAHWMGYKAY---HALGKAKRLPRMLGFQAAGAAPLVLGRPVERPET 236 Query: 223 TSVAKSLGAKTVAARALECMQVCKIHSEVVEDTEAVSAVQQLLDDERMLVEPACGAALAA 282 + A +G A+ + E V D E + A + L +E + EPA AA+A Sbjct: 237 LATAIRIGNPASWQGAVRAKEESGGVIEAVTDEEILFAYRYLAREEGIFCEPASAAAMAG 296 Query: 283 IYSGLLRRLQAEGCLPPSLTSVVVIVCGG 311 ++ L EG L P T V+ + G Sbjct: 297 VFK-----LLREGRLEPESTVVLTLTGHG 320 >3FCA-A nrPDB Length = 291 Score = 220 bits (561), Expect = 5e-58, Method: Composition-based stats. Identities = 74/304 (24%), Positives = 120/304 (39%), Gaps = 28/304 (9%) Query: 18 TPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKKG--CRHLVCSSGGNA 75 TP++ ++ + LK E P GS K R + K+G +V + GN Sbjct: 9 TPIVRLDSID----SRIALKLEKNNPGGSVKDRPALFMILDAEKRGLLKNGIVEPTSGNM 64 Query: 76 GIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTGK--VWDEANLRAQELAKR 133 GIA A K G + +PE+ S++ + L+ GAE+ LT A +A E+++ Sbjct: 65 GIAIAMIGAKRGHRVILTMPETMSVERRKVLKMLGAELVLTPGELGMKGAVEKALEISRE 124 Query: 134 DGWENVPPFDHPL-IWKGHASLVQELKAVLRTPPGALVLAVGGGGLLAGVVAGLLEVGWQ 192 G + F++P ++ + E+ + A V VG GG ++GV L Sbjct: 125 TGAHMLNQFENPYNVYSHQFTTGPEILKQMDYQIDAFVAGVGTGGTISGVGRVLKGFFGN 184 Query: 193 HVPIIAMETHGAHCFNAAITAGKLVTLPDITSVAKSLGAKTVAARALECMQVCKIHSEVV 252 V I+A+E + + GK + +GA V + L+ + ++ V Sbjct: 185 GVKIVAVEPAKSPVL-SGGQPGK--------HAIQGIGAGFV-PKILDRSVIDEVI--TV 232 Query: 253 EDTEAVSAVQQLLDDERMLVEPACGAALAAIYSGLLRRLQAEGCLPPSLTSVVVIVCGGN 312 ED EA + L E +LV + GA +AA L P V V Sbjct: 233 EDEEAYEMARYLAKKEGLLVGISSGANVAAALKVA-------QKLGPDARVVTVAPDHAE 285 Query: 313 NINS 316 S Sbjct: 286 RYLS 289 >6C2H-A nrPDB Length = 375 Score = 215 bits (546), Expect = 3e-56, Method: Composition-based stats. Identities = 66/287 (22%), Positives = 111/287 (38%), Gaps = 27/287 (9%) Query: 18 TPLLESWALSQVAGMP--VFLKCENVQPSGSFKIRGIGHFCQEMAKKGCRH-----LVCS 70 TPL+ L + G+ ++ K E P GS K R +E G H L+ Sbjct: 43 TPLIALKKLPKALGIKPQIYAKLELYNPGGSIKDRIAKSMVEEAEASGRIHPSRSTLIEP 102 Query: 71 SGGNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQ--LTGKVWDEANLR-- 126 + GN GI A G I LPE S + V L+ GAE+ T WD Sbjct: 103 TSGNTGIGLALIGAIKGYRTIITLPEKMSNEKVSVLKALGAEIIRTPTAAAWDSPESHIG 162 Query: 127 -AQELAKRDGWENV-PPFDHPLIWKGHA-SLVQELKAVLR-----TPPGALVLAVGGGGL 178 A++L K + +++ + + H +E++ L A+V G GG Sbjct: 163 VAKKLEKEIPGAVILDQYNNMMNPEAHYFGTGREIQRQLEDLNLFDNLRAVVAGAGTGGT 222 Query: 179 LAGVVAGLLEVGWQHVPIIAMETHGAHCFNAAITAGKLVTLPDITSVAKSLGAKTVAARA 238 ++G+ L E + I+ GA F + + + + DIT + Sbjct: 223 ISGISKYLKEQN-DKIQIV-----GADPFGSILAQPENLNKTDITDYKVEGIGYDFVPQV 276 Query: 239 LECMQVCKIHSEVVEDTEAVSAVQQLLDDERMLVEPACGAALAAIYS 285 L+ + + +D + +QL+ +E +LV + G+A A+ Sbjct: 277 LDRKLIDVWYK--TDDKPSFKYARQLISNEGVLVGGSSGSAFTAVVK 321 >5YBW-A nrPDB Length = 329 Score = 212 bits (539), Expect = 2e-55, Method: Composition-based stats. Identities = 63/314 (20%), Positives = 126/314 (40%), Gaps = 17/314 (5%) Query: 10 KQEPFHVVTPLLESWALSQV----AGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKKGC- 64 + + TP+ S ++ AG + K EN+Q +GSFK RG + ++ Sbjct: 17 RISKHILYTPVFTSPTFDRMVGSKAGRQFYFKAENLQKTGSFKARGALNAILCALEREPS 76 Query: 65 -RHLVCSSGGNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTGKVWDEA 123 +V S GN G A A+A+++ G+ +V+P++ ++ GAEV Sbjct: 77 LAGVVTHSSGNHGQALAWASKRAGVKCCVVVPKTAPQVKFDAMENYGAEVVKCEPNPTSR 136 Query: 124 NLRAQELAKRDGWENVPPFDHPLIWKGHASLVQELKAVLRTPPGALVLAVGGGGLLAGVV 183 + LAK G++ + D + G ++ EL A++++V GG+ +G+ Sbjct: 137 KETCEGLAKSRGYKYISSSDDYDVIAGQGTIALELLQQQPD-LDAILVSVSAGGMASGIC 195 Query: 184 AGLLEVGWQHVPIIAMETHGAHCFNAAITAGKLVTLPD--ITSVAKSLGAKTVAARALEC 241 + + +E G +L P + ++A + + + Sbjct: 196 VYTKNT-KSDLKVFLVEPEGKMLEECISKRERLWPNPPQFLDTIADGIILQQCGNKTWPI 254 Query: 242 MQVCKIHSEVVEDTE-AVSAVQQLLDDERMLVEPACGAALAAIYSGLLRRLQAEGCLPPS 300 + + + + V A++ + ++++E A GA +AA + + P Sbjct: 255 ILELPEKEVITVNNDNIVEAMRFVFARMKLVIEAAAGATVAAAMT------ERFQNFHPE 308 Query: 301 LTSVVVIVCGGNNI 314 V +I+CGGN Sbjct: 309 AKKVGIILCGGNVD 322 >1V71-A nrPDB Length = 323 Score = 209 bits (531), Expect = 2e-54, Method: Composition-based stats. Identities = 71/306 (23%), Positives = 132/306 (43%), Gaps = 12/306 (3%) Query: 10 KQEPFHVVTPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKKGCR-HLV 68 + + F TP+L S +++ VF KCEN Q G+FK RG + ++ + + ++ Sbjct: 19 RIKKFANKTPVLTSSTVNKEFVAEVFFKCENFQKMGAFKFRGALNALSQLNEAQRKAGVL 78 Query: 69 CSSGGNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTGKVWDEANLRAQ 128 S GN A A +A+ LGIPA I++P V +G G +V + + D+ A+ Sbjct: 79 TFSSGNHAQAIALSAKILGIPAKIIMPLDAPEAKVAATKGYGGQVIMYDRYKDDREKMAK 138 Query: 129 ELAKRDGWENVPPFDHPLIWKGHASLVQELKAVLRTPPGALVLAVGGGGLLAGVVAGLLE 188 E+++R+G +PP+DHP + G + +EL + P AL + +GGG L A Sbjct: 139 EISEREGLTIIPPYDHPHVLAGQGTAAKELFEEVG-PLDALFVCLGGG-GLLSGSALAAR 196 Query: 189 VGWQHVPIIAMETHGAHCFNAAITAGKLVTLPDITSVAKSLGAKTVAARALECMQVCKIH 248 + + +E + + G +V + ++A + + ++ Sbjct: 197 HFAPNCEVYGVEPEAGNDGQQSFRKGSIVHIDTPKTIADGAQTQHLGNYTFSIIKEKVDD 256 Query: 249 SEVVEDTEAVSAVQQLLDDERMLVEPACGAALAAIYSGLLRRLQAEGCLPPSLTSVVVIV 308 V D E + ++ +++VEP + AA + + + +I+ Sbjct: 257 ILTVSDEELIDCLKFYAARMKIVVEPTGCLSFAAARAMKEKL---------KNKRIGIII 307 Query: 309 CGGNNI 314 GGN Sbjct: 308 SGGNVD 313 >6AHI-A nrPDB Length = 314 Score = 208 bits (530), Expect = 2e-54, Method: Composition-based stats. Identities = 69/311 (22%), Positives = 119/311 (38%), Gaps = 31/311 (9%) Query: 17 VTPLLESWA--LSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKKGC----RHLVCS 70 TP+ + ++ K E++ P GS K R + E K G ++ Sbjct: 13 RTPVFKFTNKDYPIPLNSAIYAKLEHLNPGGSVKDRLGQYLIGEGFKTGKITSKTTIIEP 72 Query: 71 SGGNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQ--LTGKVWDEANLRAQ 128 + GN GIA A A K + V+PE S + Q ++ GA V T + A +++ Sbjct: 73 TAGNTGIALALVAIKHHLKTIFVVPEKFSTEKQQIMRALGALVINTPTSEGISGAIKKSK 132 Query: 129 ELAKRDGWENVP-PFDHPLIWKGHA-SLVQELKAVLRTPPGALVLAVGGGGLLAGVVAGL 186 ELA+ +P F++P + +L E+ L T + V +G GG AG L Sbjct: 133 ELAESIPDSYLPLQFENPDNPAAYYHTLAPEIVQELGTNLTSFVAGIGSGGTFAGTARYL 192 Query: 187 LEVGWQHVPIIAMETHGAHCFNAAITAGKLVTLPDITSVAKSLGAKTVAARALECMQVCK 246 E + +I +E G+ + G+ P + + +G + + E + + Sbjct: 193 KERI-PAIRLIGVEPEGS-----ILNGGE----PGPHEI-EGIGVEFIPP-FFENLDIDG 240 Query: 247 IHSEVVEDTEAVSAVQQLLDDERMLVEPACGAALAAIYSGLLRRLQAEGCLPPSLTSVVV 306 E + D E S ++L +LV + GAA A LP + + Sbjct: 241 F--ETISDEEGFSYTRKLAKKNGLLVGSSSGAAFVAALKEA-------QRLPEGSQVLTI 291 Query: 307 IVCGGNNINSR 317 + S+ Sbjct: 292 FPDVADRYLSK 302 >5D84-A nrPDB Length = 326 Score = 206 bits (524), Expect = 1e-53, Method: Composition-based stats. Identities = 74/328 (22%), Positives = 132/328 (40%), Gaps = 42/328 (12%) Query: 18 TPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKKGC----RHLVCSSGG 73 TP+++ L VF K E + P GS K R + + K G HL+ S+ G Sbjct: 19 TPMVQLHQL--FPKHEVFAKLEYMNPGGSMKDRPAKYIIEHGIKHGLITENTHLIESTSG 76 Query: 74 NAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQL------TGKVWDEANLRA 127 N GIA A A+ G+ T V+ S ++ ++ GA V++ G + Sbjct: 77 NLGIALAMIAKIKGLKLTCVVDPKISPTNLKIIKSYGANVEMVEEPDAHGGYLMTRIAKV 136 Query: 128 QE-LAKRDGWENVPPFDHPLIWKGHASLV-QELKAVLRTPPGALVLAVGGGGLLAGVVAG 185 QE LA D + + + L W+ H E+ ++ P V V G + G+ Sbjct: 137 QELLATIDDAYWINQYANELNWQSHYHGAGTEIVETIKQPIDYFVAPVSTTGSIMGMSRK 196 Query: 186 LLEVGWQHVPIIAMETHGAHCFNAAITAGKLVTLPDITSVAKSLGAKTVAARALECMQVC 245 + EV + I+A++ G+ F +L +GA +R E + Sbjct: 197 IKEV-HPNAQIVAVDAKGSVIFGDKPINRELP----------GIGA----SRVPEILNRS 241 Query: 246 KIHSEV-VEDTEAVSAVQQLLDDERMLVEPACGAALAAIYSGLLRRLQAEGCLPPSLTSV 304 +I+ + V+D ++ ++L+D E + + G+ +AAI Q + T V Sbjct: 242 EINQVIHVDDYQSALGCRKLIDYEGIFAGGSTGSIIAAI-------EQLITSIEEGATIV 294 Query: 305 VVIVCGGNN-----INSRELQALKTHLG 327 ++ G+ + L+ +K+ G Sbjct: 295 TILPDRGDRYLDLVYSDTWLEKMKSRQG 322 >5XA2-A nrPDB Length = 309 Score = 203 bits (516), Expect = 9e-53, Method: Composition-based stats. Identities = 77/310 (24%), Positives = 118/310 (38%), Gaps = 25/310 (8%) Query: 17 VTPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKKGC----RHLVCSSG 72 TPL++ L+ V K E P+ S K R + + G H+V + Sbjct: 13 RTPLVQINRLTAGLSSRVLAKIEGRNPAYSVKCRIGAAMIWDAEQSGKLKPGMHVVEPTS 72 Query: 73 GNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTGK--VWDEANLRAQEL 130 GN GIA A+ G T+ +PE+ S++ L+ GA++ LT A +A+EL Sbjct: 73 GNTGIALAFVCAARGYKLTLTMPETMSIERRMMLKSFGADLVLTPGADGMKGAISKAEEL 132 Query: 131 AKRDGWENVPPFDHPLIWKGH-ASLVQELKAVLRTPPGALVLAVGGGGLLAGVVAGLLEV 189 A + GW F +P H + E+ V VG GG + GV L Sbjct: 133 AAQPGWFIPQQFKNPANPAIHVKTTGPEIWNDTEGQVDVFVAGVGTGGTITGVARFLKHE 192 Query: 190 GWQHVPIIAMETHGAHCFNAAITAGKLVTLPDITSVAKSLGAKTVAARALECMQVCKIHS 249 V ++A+E + + + +GA V + V +I S Sbjct: 193 KKHPVHVVAVEPAASPVLAGGPAGRHKI---------QGIGAGFVPD-TFDRSVVDEILS 242 Query: 250 EVVEDTEAVSAVQQLLDDERMLVEPACGAALAAIYSGLLRRLQAEGCLPPSLTSVVVIVC 309 V D EA+ ++L +E + +CGAA+A R A T V V+ Sbjct: 243 --VTDDEAIETARKLAMEEGISCGISCGAAMAGALKVAARPEFA------GKTIVTVLPD 294 Query: 310 GGNNINSREL 319 G S L Sbjct: 295 AGERYLSTAL 304 >1M54-A nrPDB Length = 363 Score = 201 bits (512), Expect = 3e-52, Method: Composition-based stats. Identities = 64/316 (20%), Positives = 112/316 (35%), Gaps = 28/316 (8%) Query: 18 TPLLESWALSQVAG--MPVFLKCENVQPSGSFKIRGIGHFCQEMAKKGC----RHLVCSS 71 TP++ + + G + KCE GS K R ++ + G ++ + Sbjct: 44 TPMVRINKIGKKFGLKCELLAKCEFFNAGGSVKDRISLRMIEDAERDGTLKPGDTIIEPT 103 Query: 72 GGNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTGKV--WDEANLR--- 126 GN GI A AA G IV+PE S + V L+ GAE+ T +D Sbjct: 104 SGNTGIGLALAAAVRGYRCIIVMPEKMSSEKVDVLRALGAEIVRTPTNARFDSPESHVGV 163 Query: 127 AQELAKRDGWENV-PPFDHPLI-WKGHASLVQELKAVLRTPPGALVLAVGGGGLLAGVVA 184 A L ++ + + + + E+ LV +VG GG + G+ Sbjct: 164 AWRLKNEIPNSHILDQYRNASNPLAHYDTTADEILQQCDGKLDMLVASVGTGGTITGIAR 223 Query: 185 GLLEVGWQHVPIIAMETHGAHCFNAAITAGKLVTLPDITSVAKSLGAKTVAARALECMQV 244 L E II ++ G+ + + + + T+ L+ V Sbjct: 224 KLKE-KCPGCRIIGVDPEGS-----ILAEPEELNQTEQTTYEVEGIGYDFIPTVLDRTVV 277 Query: 245 CKIHSEVVEDTEAVSAVQQLLDDERMLVEPACGAALAAIYSGLLRRLQAEGCLPPSLTSV 304 K D EA + + L+ E +L + G+ +A ++A L V Sbjct: 278 DKWFKS--NDEEAFTFARMLIAQEGLLCGGSAGSTVAVA-------VKAAQELQEGQRCV 328 Query: 305 VVIVCGGNNINSRELQ 320 V++ N ++ L Sbjct: 329 VILPDSVRNYMTKFLS 344 >4COO-A nrPDB Length = 563 Score = 201 bits (511), Expect = 3e-52, Method: Composition-based stats. Identities = 64/316 (20%), Positives = 112/316 (35%), Gaps = 28/316 (8%) Query: 18 TPLLESWALSQVAG--MPVFLKCENVQPSGSFKIRGIGHFCQEMAKKGC----RHLVCSS 71 TP++ + + G + KCE GS K R ++ + G ++ + Sbjct: 109 TPMVRINKIGKKFGLKCELLAKCEFFNAGGSVKDRISLRMIEDAERDGTLKPGDTIIEPT 168 Query: 72 GGNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTGKV--WDEANLR--- 126 GN GI A AA G IV+PE S + V L+ GAE+ T +D Sbjct: 169 SGNTGIGLALAAAVRGYRCIIVMPEKMSSEKVDVLRALGAEIVRTPTNARFDSPESHVGV 228 Query: 127 AQELAKRDGWENV-PPFDHPLI-WKGHASLVQELKAVLRTPPGALVLAVGGGGLLAGVVA 184 A L ++ + + + + E+ LV +VG GG + G+ Sbjct: 229 AWRLKNEIPNSHILDQYRNASNPLAHYDTTADEILQQCDGKLDMLVASVGTGGTITGIAR 288 Query: 185 GLLEVGWQHVPIIAMETHGAHCFNAAITAGKLVTLPDITSVAKSLGAKTVAARALECMQV 244 L E II ++ G+ + + + + T+ L+ V Sbjct: 289 KLKE-KCPGCRIIGVDPEGS-----ILAEPEELNQTEQTTYEVEGIGYDFIPTVLDRTVV 342 Query: 245 CKIHSEVVEDTEAVSAVQQLLDDERMLVEPACGAALAAIYSGLLRRLQAEGCLPPSLTSV 304 K D EA + + L+ E +L + G+ +A ++A L V Sbjct: 343 DKWFKS--NDEEAFTFARMLIAQEGLLCGGSAGSTVAVA-------VKAAQELQEGQRCV 393 Query: 305 VVIVCGGNNINSRELQ 320 V++ N ++ L Sbjct: 394 VILPDSVRNYMTKFLS 409 >5MMS-A nrPDB Length = 408 Score = 200 bits (508), Expect = 7e-52, Method: Composition-based stats. Identities = 64/316 (20%), Positives = 112/316 (35%), Gaps = 28/316 (8%) Query: 18 TPLLESWALSQVAG--MPVFLKCENVQPSGSFKIRGIGHFCQEMAKKGC----RHLVCSS 71 TP++ + + G + KCE GS K R ++ + G ++ + Sbjct: 87 TPMVRINKIGKKFGLKCELLAKCEFFNAGGSVKDRISLRMIEDAERDGTLKPGDTIIEPT 146 Query: 72 GGNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTGKV--WDEANLR--- 126 GN GI A AA G IV+PE S + V L+ GAE+ T +D Sbjct: 147 SGNTGIGLALAAAVRGYRCIIVMPEKMSSEKVDVLRALGAEIVRTPTNARFDSPESHVGV 206 Query: 127 AQELAKRDGWENV-PPFDHPLI-WKGHASLVQELKAVLRTPPGALVLAVGGGGLLAGVVA 184 A L ++ + + + + E+ LV +VG GG + G+ Sbjct: 207 AWRLKNEIPNSHILDQYRNASNPLAHYDTTADEILQQCDGKLDMLVASVGTGGTITGIAR 266 Query: 185 GLLEVGWQHVPIIAMETHGAHCFNAAITAGKLVTLPDITSVAKSLGAKTVAARALECMQV 244 L E II ++ G+ + + + + T+ L+ V Sbjct: 267 KLKE-KCPGCRIIGVDPEGS-----ILAEPEELNQTEQTTYEVEGIGYDFIPTVLDRTVV 320 Query: 245 CKIHSEVVEDTEAVSAVQQLLDDERMLVEPACGAALAAIYSGLLRRLQAEGCLPPSLTSV 304 K D EA + + L+ E +L + G+ +A ++A L V Sbjct: 321 DKWFKS--NDEEAFTFARMLIAQEGLLCGGSAGSTVAVA-------VKAAQELQEGQRCV 371 Query: 305 VVIVCGGNNINSRELQ 320 V++ N ++ L Sbjct: 372 VILPDSVRNYMTKFLS 387 >5OHX-A nrPDB Length = 504 Score = 197 bits (500), Expect = 7e-51, Method: Composition-based stats. Identities = 61/273 (22%), Positives = 106/273 (38%), Gaps = 22/273 (8%) Query: 18 TPLLESWALSQVAG--MPVFLKCENVQPSGSFKIRGIGHFCQEMAKKGCR----HLVCSS 71 TPL++ + + G ++ KCE + P GS K R Q+ KG ++ + Sbjct: 46 TPLIKLNNIPKSYGIKCEIYAKCEFLNPGGSVKDRIAYRMIQDAEDKGLLKPGCTIIEPT 105 Query: 72 GGNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQ--LTGKVWDEANLR--- 126 GN GI A AA G IV+PE S + + L GA++ T W Sbjct: 106 SGNTGIGLAMAAAVRGYKCIIVMPEKMSDEKISTLYALGAKIIRTPTEASWHSPEAHISV 165 Query: 127 AQELAKRDGWENV-PPFDHPLI-WKGHASLVQELKAVLRTPPGALVLAVGGGGLLAGVVA 184 AQ+L K + + +P + E+ LV G GG ++G+ Sbjct: 166 AQKLQKEIPNSIILDQYTNPGNPLAHYDQTAIEIWKQCEGKIDYLVAGAGTGGTISGIGR 225 Query: 185 GLLEVGWQHVPIIAMETHGAHCFNAAITAGKLVTLPDITSVAKSLGAKTVAARALECMQV 244 L E+ ++ IIA++ G+ ++ + + + L+ + Sbjct: 226 KLKELS-PNIKIIAVDPKGSILDPSSDSQNE------VGFYEVEGIGYDFIPTVLDRNVI 278 Query: 245 CKIHSEVVEDTEAVSAVQQLLDDERMLVEPACG 277 K ED E+++A + L+ E +L + G Sbjct: 279 DKWIK--TEDNESLNAARMLIRQEGLLCGGSSG 309 >2GN1-A nrPDB Length = 342 Score = 196 bits (499), Expect = 8e-51, Method: Composition-based stats. Identities = 73/305 (23%), Positives = 131/305 (42%), Gaps = 10/305 (3%) Query: 17 VTPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKKGC-RHLVCSSGGNA 75 T + S S+ +FLK EN+Q +GSFKIRG + + + + +V S GN Sbjct: 40 KTGMPRSNYFSERCKGEIFLKFENMQRTGSFKIRGAFNKLSSLTEAEKRKGVVACSAGNH 99 Query: 76 GIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTGKVWDEANLRAQELAKRDG 135 + + LGI +V+P+ V AEV L G +++ + E+ + +G Sbjct: 100 AQGVSLSCAMLGIDGKVVMPKGAPKSKVAATCDYSAEVVLHGDNFNDTIAKVSEIVETEG 159 Query: 136 WENVPPFDHPLIWKGHASLVQELKAVLRTPPGALVLAVGGGGLLAGVVAGLLEVGWQHVP 195 +PP+D P + G ++ E+ L +++ +GGGGL+AG+ + + + Sbjct: 160 RIFIPPYDDPKVIAGQGTIGLEIMEDLYDV-DNVIVPIGGGGLIAGIAIAIKSIN-PTIK 217 Query: 196 IIAMETHGAHCFNAAITAGKLVTLPDITSVAKSLGAKTVAARALECMQVCKIHSEVVEDT 255 +I ++ H A+ G++ T ++A E ++ +V + Sbjct: 218 VIGVQAENVHGMAASYYTGEITTHRTTGTLADGCDVSRPGNLTYEIVRELVDDIVLVSED 277 Query: 256 EAVSAVQQLLDDERMLVEPACGAALAAIYSGLLRRLQAEGCLPPSLTSVVVIVCGGNNIN 315 E +++ L+ +++ E A A AA+ SG L V I+ GGN Sbjct: 278 EIRNSMIALIQRNKVITEGAGALACAALLSGKLDSHI-------QNRKTVSIISGGNIDL 330 Query: 316 SRELQ 320 SR Q Sbjct: 331 SRVSQ 335 >2BHS-A nrPDB Length = 303 Score = 193 bits (491), Expect = 6e-50, Method: Composition-based stats. Identities = 60/307 (19%), Positives = 110/307 (35%), Gaps = 35/307 (11%) Query: 18 TPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKKG----CRHLVCSSGG 73 TPL++ + G V+LK E P+GS K R E K+G L+ ++ G Sbjct: 11 TPLVKLQRMGPDNGSEVWLKLEGNNPAGSVKDRAALSMIVEAEKRGEIKPGDVLIEATSG 70 Query: 74 NAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLT--GKVWDEANLRAQELA 131 N GIA A A G +++P++ S + ++ GAE+ L + + A A E+A Sbjct: 71 NTGIALAMIAALKGYRMKLLMPDNMSQERRAAMRAYGAELILVTKEQGMEGARDLALEMA 130 Query: 132 KRDGWENVPPFDHPLI-WKGHASLVQELKAVLRTPPGALVLAVGGGGLLAGVVAGLLEVG 190 R + + F++P + + + E+ V ++G G + GV + E Sbjct: 131 NRGEGKLLDQFNNPDNPYAHYTTTGPEIWQQTGGRITHFVSSMGTTGTITGVSRFMREQS 190 Query: 191 WQHVPIIAMETHGAHCFNAAITAGKLVTLPDITSVAKSLGAKTVAARALECMQVCKIHSE 250 V I+ ++ T + ++ L+ Q ++ Sbjct: 191 KP-VTIVGLQPEEGSSI--------PGIRRWPTEYLPGIFNASLVDEVLDIHQRDAENT- 240 Query: 251 VVEDTEAVSAVQQLLDDERMLVEPACGAALAAIYSGLLRRLQAEGCLPPSLTSVVVIVCG 310 +++L E + + G A+A P V +I Sbjct: 241 ----------MRELAVREGIFCGVSSGGAVAGALR--------VAKANPDAVVVAIICDR 282 Query: 311 GNNINSR 317 G+ S Sbjct: 283 GDRYLST 289 >2JC3-A nrPDB Length = 303 Score = 192 bits (488), Expect = 2e-49, Method: Composition-based stats. Identities = 56/307 (18%), Positives = 109/307 (35%), Gaps = 35/307 (11%) Query: 18 TPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKKG----CRHLVCSSGG 73 TPL++ + G +++K E P+GS K R E K+G L+ ++ G Sbjct: 11 TPLVKLQRIGPDNGSEIWVKLEGNNPAGSVKDRAALSMIVEAEKRGEIKPGDVLIEATSG 70 Query: 74 NAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLT--GKVWDEANLRAQELA 131 N GIA A A G +++P++ S + ++ GAE+ L + + A A ++ Sbjct: 71 NTGIALAMIAALKGYRMKLLMPDNMSQERRAAMRAYGAELILVTKEQGMEGARDLALAMS 130 Query: 132 KRDGWENVPPFDHPLI-WKGHASLVQELKAVLRTPPGALVLAVGGGGLLAGVVAGLLEVG 190 +R + + F++P + + + E+ V ++G G + GV L E Sbjct: 131 ERGEGKLLDQFNNPDNPYAHYTTTGPEIWRQTSGRITHFVSSMGTTGTITGVSRFLREQE 190 Query: 191 WQHVPIIAMETHGAHCFNAAITAGKLVTLPDITSVAKSLGAKTVAARALECMQVCKIHSE 250 V I+ ++ + ++ L+ Q ++ Sbjct: 191 KP-VTIVGLQPEEGSSI--------PGIRRWPAEYMPGIFNASLVDEVLDIHQNDAENT- 240 Query: 251 VVEDTEAVSAVQQLLDDERMLVEPACGAALAAIYSGLLRRLQAEGCLPPSLTSVVVIVCG 310 +++L E + + G A+A P V +I Sbjct: 241 ----------MRELAVREGIFCGVSSGGAVAGALR--------VARATPGAIVVAIICDR 282 Query: 311 GNNINSR 317 G+ S Sbjct: 283 GDRYLST 289 >2Q3D-A nrPDB Length = 313 Score = 191 bits (486), Expect = 2e-49, Method: Composition-based stats. Identities = 77/313 (24%), Positives = 121/313 (38%), Gaps = 27/313 (8%) Query: 17 VTPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKKGC----RHLVCSSG 72 TPL+ ++ A + K E P+ S K R Q + G ++ + Sbjct: 16 RTPLVRLRRVTDGAVADIVAKLEFFNPANSVKDRIGVAMLQAAEQAGLIKPDTIILEPTS 75 Query: 73 GNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTGK--VWDEANLRAQEL 130 GN GIA A G + +PE+ SL+ L+ GAE+ LT A +A+EL Sbjct: 76 GNTGIALAMVCAARGYRCVLTMPETMSLERRMLLRAYGAELILTPGADGMSGAIAKAEEL 135 Query: 131 AKRDGWENVP-PFDHPLIWKGHA-SLVQELKAVLRTPPGALVLAVGGGGLLAGVVAGLLE 188 AK D VP F++P H + +E+ +V VG GG + GV + E Sbjct: 136 AKTDQRYFVPQQFENPANPAIHRVTTAEEVWRDTDGKVDIVVAGVGTGGTITGVAQVIKE 195 Query: 189 VGWQHVPIIAMETHGAHCFNAAITAGKLVTLPDITSVAKSLGAKTVAARALECMQVCKIH 248 +A+E + + + + +GA V Q Sbjct: 196 R-KPSARFVAVEPAASPVLSGGQKGPHPI---------QGIGAGFVPPV---LDQDLVDE 242 Query: 249 SEVVEDTEAVSAVQQLLDDERMLVEPACGAALAAIYSGLLRRLQAEGCLPPSLTSVVVIV 308 V + +A++ ++L +E +LV + GAA A + RR + G L VVV+ Sbjct: 243 IITVGNEDALNVARRLAREEGLLVGISSGAATVAALQ-VARRPENAGKL-----IVVVLP 296 Query: 309 CGGNNINSRELQA 321 G S L A Sbjct: 297 DFGERYLSTPLFA 309 >5XW3-A nrPDB Length = 315 Score = 187 bits (474), Expect = 7e-48, Method: Composition-based stats. Identities = 68/310 (21%), Positives = 118/310 (38%), Gaps = 29/310 (9%) Query: 18 TPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKKGCRH----LVCSSGG 73 TP++E S G+ +F K E P GS K R ++ +KG ++ + G Sbjct: 14 TPIVEITRFSLPEGVRLFAKLEFYNPGGSVKDRLGRELIEDALEKGLVTEGGTIIEPTAG 73 Query: 74 NAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTG--KVWDEANLRAQELA 131 N GI A AA + + + +PE S++ + ++ GA V T + A +A+EL Sbjct: 74 NTGIGLALAALQHDLRVIVCVPEKFSIEKQELMKALGATVVHTPTEQGMTGAIAKAKELV 133 Query: 132 KRDGWENVP-PFDHPLIWKGH-ASLVQELKAVLRTPPGALVLAVGGGGLLAGVVAGLLEV 189 P F + + + +L EL + L V G GG G + L E Sbjct: 134 NEIPNSYSPSQFANEANPRAYFKTLGPELWSALNGEINIFVAGAGTGGTFMGTASYLKEK 193 Query: 190 GWQHVPIIAMETHGAHCFNAAITAGKLVTLPDITSVAKSLGAKTVAARALECMQVCKIHS 249 + + +E G+ + GK + + +G + + L+ +IH Sbjct: 194 NI-DIKTVIVEPEGS-----ILNGGKAGSHE-----TEGIGLEFIPP-FLKTSYFDEIH- 240 Query: 250 EVVEDTEAVSAVQQLLDDERMLVEPACGAALAAIYSGLLRRLQAEGCLPPSLTSVVVIVC 309 + D A V++L E +LV + GAA A + P V + Sbjct: 241 -TISDRNAFLRVKELAQKEGLLVGSSSGAAFHASLLEAEKAA-------PGTNIVTIFPD 292 Query: 310 GGNNINSREL 319 S+++ Sbjct: 293 SSERYLSKDI 302 >5J5V-A nrPDB Length = 323 Score = 187 bits (474), Expect = 7e-48, Method: Composition-based stats. Identities = 76/314 (24%), Positives = 131/314 (41%), Gaps = 25/314 (7%) Query: 18 TPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKKG----CRHLVCSSGG 73 TPL+ + + K E+ PS S K R + + K+G LV + G Sbjct: 15 TPLVRLNRIGNG---RILAKVESRNPSFSVKCRIGANMIWDAEKRGVLKPGVELVEPTSG 71 Query: 74 NAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLT--GKVWDEANLRAQELA 131 N GIA AY A G T+ +PE+ S++ + L+ GA + LT K A +A+E+ Sbjct: 72 NTGIALAYVAAARGYKLTLTMPETMSIERRKLLKALGANLVLTEGAKGMKGAIQKAEEIV 131 Query: 132 KRDGWEN--VPPFDHPLIWKGH-ASLVQELKAVLRTPPGALVLAVGGGGLLAGVVAGLLE 188 + + + F +P + H + E+ + VG GG L GV + Sbjct: 132 ASNPEKYLLLQQFSNPANPEIHEKTTGPEIWEDTDGQVDVFIAGVGTGGTLTGVSRYIKG 191 Query: 189 V-GWQHVPIIAMETHGAHCFNAAITAGKLVTLPDITSVAKSLGAKTVAARALECMQVCKI 247 G + +A+E + A+ ++ P + + +GA + A L+ V K+ Sbjct: 192 TKGKTDLISVAVEPTDSPVIAQALAGEEI--KPGPHKI-QGIGAGFIPAN-LDLKLVDKV 247 Query: 248 HSEVVEDTEAVSAVQQLLDDERMLVEPACGAALAAIYSGLLRRLQAEGCLPPSLTSVVVI 307 + + EA+S ++L+++E +L + GAA+AA E + VV++ Sbjct: 248 IG--ITNEEAISTARRLMEEEGILAGISSGAAVAAALK------LQEDESFTNKNIVVIL 299 Query: 308 VCGGNNINSRELQA 321 G S L A Sbjct: 300 PSSGERYLSTALFA 313 >1VE5-A nrPDB Length = 311 Score = 186 bits (473), Expect = 9e-48, Method: Composition-based stats. Identities = 82/312 (26%), Positives = 136/312 (43%), Gaps = 17/312 (5%) Query: 10 KQEPFHVVTPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKKGCRHLVC 69 + P+ TPLL S L + G + LK E++Q +GSFK RG + +A + + L+ Sbjct: 13 RIAPYTHRTPLLTSRLLDGLLGKRLLLKAEHLQKTGSFKARGA--LSKALALENPKGLLA 70 Query: 70 SSGGNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTGKVWDEANLRAQE 129 S GN AYAA+ LG+ A +V+PE S + GAEV G A+ Sbjct: 71 VSSGNHAQGVAYAAQVLGVKALVVMPEDASPYKKACARAYGAEVVDRGVTAKNREEVARA 130 Query: 130 LAKRDGWENVPPFDHPLIWKGHASLVQELKAV---LRTPPGALVLAVGGGGLLAGVVAGL 186 L + G+ + PFD PL+ G + EL A + PGA++ VGGG L +A Sbjct: 131 LQEETGYALIHPFDDPLVIAGQGTAGLELLAQAGRMGVFPGAVLAPVGGG-GLLAGLATA 189 Query: 187 LEVGWQHVPIIAMETHGAHCFNAAITAGKLVTLP-DITSVAKSLGAKTVAARALECMQVC 245 ++ ++ +E A ++ AG+++ L + A + ++ R ++ Sbjct: 190 VKALSPTTLVLGVEPEAADDAKRSLEAGRILRLEAPPRTRADGVRTLSLGERTFPILRER 249 Query: 246 KIHSEVVEDTEAVSAVQQLLDDERMLVEPACGAALAAIYSGLLRRLQAEGCLPPSLTSVV 305 V + + A + L + +VEP LAA+ R Q ++ Sbjct: 250 VDGILTVSEEALLEAERLLFTRTKQVVEPTGALPLAAVLEHGARLPQ----------TLA 299 Query: 306 VIVCGGNNINSR 317 +++ GGN S Sbjct: 300 LLLSGGNRDFSP 311 >5XEM-A nrPDB Length = 310 Score = 184 bits (466), Expect = 6e-47, Method: Composition-based stats. Identities = 63/307 (20%), Positives = 110/307 (35%), Gaps = 26/307 (8%) Query: 18 TPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKKGC----RHLVCSSGG 73 TPL++ + G +++K E P S K R +E K+G ++ ++ G Sbjct: 17 TPLVKINNIDT-FGNEIYVKLEGSNPGRSTKDRIALKMIEEAEKEGLIDKDTVIIEATSG 75 Query: 74 NAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTGK--VWDEANLRAQELA 131 N GI A IV+P++ S++ +Q ++ G EV LT + +EL Sbjct: 76 NTGIGLAMICAVKNYKLKIVMPDTMSIERIQLMRAYGTEVILTDGSLGMKACLEKLEELK 135 Query: 132 KRDGWENVP-PFDHPLIWKGHA-SLVQELKAVLRTPPGALVLAVGGGGLLAGVVAGLLEV 189 K + VP F + K H + +E+ L + G GG +G L E Sbjct: 136 KNEKKYFVPNQFTNVNNPKAHYETTAEEILKDLNNKVDVFICGTGTGGSFSGTAKKLKEK 195 Query: 190 GWQHVPIIAMETHGAHCFNAAITAGKLVTLPDITSVAKSLGAKTVAARALECMQVCKIHS 249 ++ +E + + + ++ G V +L Sbjct: 196 L-PNIKTFPVEPASSPLLSKGYIGPHKIQGMGMSI----GGIPAVYDGSL------ADDI 244 Query: 250 EVVEDTEAVSAVQQLLDDERMLVEPACGAALAAIYSGLLRRLQAEGCLPPSLTSVVVIVC 309 V ED +A +++L E +L + GA A ++ L VV+ Sbjct: 245 LVCEDDDAFEMMRELSFKEGILGGISTGATFKAALDY------SKENADKGLKIVVLSTD 298 Query: 310 GGNNINS 316 G S Sbjct: 299 SGEKYLS 305 >4I1Y-A nrPDB Length = 314 Score = 183 bits (465), Expect = 6e-47, Method: Composition-based stats. Identities = 73/312 (23%), Positives = 123/312 (39%), Gaps = 27/312 (8%) Query: 18 TPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKKGC----RHLVCSSGG 73 TPL+ ++ A V K E+ P+GS K R K G ++ + G Sbjct: 18 TPLVRLRRVTDGAAADVVAKLESFNPAGSIKDRIGVAMIDAAEKAGLIKPDTIILEPTSG 77 Query: 74 NAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTG--KVWDEANLRAQELA 131 N GIA A + G + +P++ S++ L+ GAE+ LT + A +A+ELA Sbjct: 78 NTGIALAMVSAARGYKCVLTMPDTMSIERRMLLRAYGAELVLTPGAEGMAGAIAKAEELA 137 Query: 132 KRDGWENVP-PFDHPLIWKGHA-SLVQELKAVLRTPPGALVLAVGGGGLLAGVVAGLLEV 189 K D +P F++P HA + +E+ V VG GG + GV + + Sbjct: 138 KTDDRYFIPQQFENPANPAVHAVTTAEEVWRDTDGKVDIFVSGVGTGGTITGVAQVIKQR 197 Query: 190 GWQHVPIIAMETHGAHCFNAAITAGKLVTLPDITSVAKSLGAKTVAARALECMQVCKIHS 249 +A+E + + + + +GA V L+ V ++ + Sbjct: 198 -RPSAQFVAVEPAASPVLSGGQKGPHPI---------QGIGAGFVPP-VLDLALVDEVIT 246 Query: 250 EVVEDTEAVSAVQQLLDDERMLVEPACGAALAAIYSGLLRRLQAEGCLPPSLTSVVVIVC 309 +D A+ +++ +E +L + GAA+ A R A VVV+ Sbjct: 247 VGNDD--ALELARRMATEEGLLFGISSGAAVWAARELAHRPENA------GKLIVVVLPD 298 Query: 310 GGNNINSRELQA 321 G S L A Sbjct: 299 FGERYLSTVLFA 310 >2EGU-A nrPDB Length = 308 Score = 182 bits (462), Expect = 2e-46, Method: Composition-based stats. Identities = 70/309 (22%), Positives = 116/309 (37%), Gaps = 27/309 (8%) Query: 18 TPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKKGC----RHLVCSSGG 73 TP ++ + V+LK E + P S K R + K G +V + G Sbjct: 15 TPAVKLNRIVDEDSADVYLKLEFMNPGSSVKDRIALAMIEAAEKAGKLKPGDTIVEPTSG 74 Query: 74 NAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTGK--VWDEANLRAQELA 131 N GI A A G A +V+P++ SL+ L+ GAE+ LT A +A+EL Sbjct: 75 NTGIGLAMVAAAKGYKAVLVMPDTMSLERRNLLRAYGAELVLTPGAQGMRGAIAKAEELV 134 Query: 132 KRDGWENVPPFDHPLIWKGHA-SLVQELKAVLRTPPGALVLAVGGGGLLAGVVAGLLEVG 190 + G+ F + + H + +E+ + A V VG GG + G L E Sbjct: 135 REHGYFMPQQFKNEANPEIHRLTTGKEIVEQMGDQLDAFVAGVGTGGTITGAGKVLREA- 193 Query: 191 WQHVPIIAMETHGAHCFNAAITAGKLVTLPDITSVAKSLGAKTVAARALECMQVCKIHSE 250 + ++ I A+E + + + + +GA V L+ + Sbjct: 194 YPNIKIYAVEPADSPVLSGGKPGPHKI---------QGIGAGFVPD-ILDTSIYDGVI-- 241 Query: 251 VVEDTEAVSAVQQLLDDERMLVEPACGAALAAIYSGLLRRLQAEGCLPPSLTSVVVIVCG 310 V EA +A ++ +E +L + GAA+ A L + +I Sbjct: 242 TVTTEEAFAAARRAAREEGILGGISSGAAIHAALKVA-------KELGKGKKVLAIIPSN 294 Query: 311 GNNINSREL 319 G S L Sbjct: 295 GERYLSTPL 303 >2EFY-A nrPDB Length = 304 Score = 181 bits (460), Expect = 3e-46, Method: Composition-based stats. Identities = 67/314 (21%), Positives = 114/314 (36%), Gaps = 29/314 (9%) Query: 17 VTPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKKG------CRHLVCS 70 TP++ + + V++K E + P GS K R + ++ ++G + +V Sbjct: 9 KTPVVRLAKVVEPDMAEVWVKLEGLNPGGSIKDRPAWYMIKDAEERGILRPGSGQVIVEP 68 Query: 71 SGGNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTGKV--WDEANLRAQ 128 + GN GI A A G + +P S + + L+ GAE+ LT A A Sbjct: 69 TSGNTGIGLAMIAASRGYRLILTMPAQMSEERKRVLKAFGAELVLTDPERRMLAAREEAL 128 Query: 129 ELAKRDGWENVPPFDHPLIWKGHA-SLVQELKAVLRTPPGALVLAVGGGGLLAGVVAGLL 187 L + G F +P + H + EL L A V G GG + GV L Sbjct: 129 RLKEELGAFMPDQFKNPANVRAHYETTGPELYEALEGRIDAFVYGSGTGGTITGVGRYLK 188 Query: 188 EVGWQHVPIIAMETHGAHCFNAAITAGKLVTLPDITSVAKSLGAKTVAARALECMQVCKI 247 E HV +IA+E ++ + + +G + L+ + + Sbjct: 189 ERI-PHVKVIAVEPARSNVLSGGKMGQHGF---------QGMGPGFIPEN-LDLSLLDGV 237 Query: 248 HSEVVEDTEAVSAVQQLLDDERMLVEPACGAALAAIYSGLLRRLQAEGCLPPSLTSVVVI 307 V + +A ++L +E + + + G + A Q L P + Sbjct: 238 IQ--VWEEDAFPLARRLAREEGLFLGMSSGGIVWAAL-------QVARELGPGKRVACIS 288 Query: 308 VCGGNNINSRELQA 321 GG S L A Sbjct: 289 PDGGWKYLSTPLYA 302 >4LMA-A nrPDB Length = 326 Score = 181 bits (458), Expect = 5e-46, Method: Composition-based stats. Identities = 76/314 (24%), Positives = 123/314 (39%), Gaps = 30/314 (9%) Query: 17 VTPLLESWALSQVAGM--PVFLKCENVQPSGSFKIRGIGHFCQEMAKKGC-----RHLVC 69 TPL++ + Q G + +K E + P+ S K R H K G LV Sbjct: 20 RTPLVQLNRIPQAEGCLGRIVMKLEGMNPAASVKDRIGTHMINSAEKAGLINPETTVLVE 79 Query: 70 SSGGNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTGK--VWDEANLRA 127 + GN GIA A A G + +PE+ SL+ L+ GA ++LT A LRA Sbjct: 80 PTSGNTGIALAMTAAAKGYRLILTMPETMSLERRAMLKAYGATLELTPGSQGMKGAILRA 139 Query: 128 QELAKRD-GWENVPPFDHPLIWKGHA-SLVQELKAVLRTPPGALVLAVGGGGLLAGVVAG 185 Q++ G + F +P + H + +E+ +V VG GG + GV Sbjct: 140 QQIVDSIPGAYMLQQFRNPSNPEIHRLTTAEEIWQDTEGQVDFIVAGVGTGGTITGVAEV 199 Query: 186 LLEVGWQHVPIIAMETHGAHCFNAAITAGKLVTLPDITSVAKSLGAKTVAARALECMQVC 245 + ++A+E + + P + + +GA + L + Sbjct: 200 IKSR-KPSFQVVAVEPFNSPVISGG--------NPGPHKI-QGIGAGFI-PEVLRTDLID 248 Query: 246 KIHSEVVEDTEAVSAVQQLLDDERMLVEPACGAALAAIYSGLLRRLQAEGCLPPSLTSVV 305 ++ V D EA ++L +E +L + GA L A L +R + EG L VV Sbjct: 249 EVI--TVSDEEAFQFGRRLAKEEGLLSGISSGANLCAAIQ-LAQRPENEGKL-----IVV 300 Query: 306 VIVCGGNNINSREL 319 + G S + Sbjct: 301 IQPSFGERYLSTLM 314 >3VBE-A nrPDB Length = 344 Score = 180 bits (457), Expect = 6e-46, Method: Composition-based stats. Identities = 63/277 (22%), Positives = 107/277 (38%), Gaps = 22/277 (7%) Query: 17 VTPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKK-----GCRHLVCSS 71 TPL+ +++ G V +K E +QP+ S K R + +K G L+ + Sbjct: 35 RTPLVYLNKVTEGCGAYVAVKQEMMQPTASIKDRPAYAMITDAEEKNLITPGKTTLIEPT 94 Query: 72 GGNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTG--KVWDEANLRAQE 129 GN GI+ A+ A G + +P TSL+ ++ GAE+ LT K +A E Sbjct: 95 SGNMGISMAFMAAMKGYKMVLTMPSYTSLERRVTMRAFGAELILTDPAKGMGGTVKKAYE 154 Query: 130 LAKRDG-WENVPPFDHPLIWKGH-ASLVQELKAVLRTPPGALVLAVGGGGLLAGVVAGLL 187 L + + F +P + H + E+ V+ +G GG ++GV L Sbjct: 155 LLENTPNAHMLQQFSNPANTQVHFETTGPEIWEDTNGQVDIFVMGIGSGGTVSGVGQYLK 214 Query: 188 EVGWQHVPIIAMETHGAHCFNAAITAGKLVTLPDITSVAKSLGAKTVAARALECMQVCKI 247 +V I +E ++ N +T + + V + LE Sbjct: 215 SKN-PNVKIYGVEPSESNVLNGGKPGPHHITGNGVG-FKPDILDLDVMEKVLE------- 265 Query: 248 HSEVVEDTEAVSAVQQLLDDERMLVEPACGAALAAIY 284 V +AV+ + L E ++V + GA A Sbjct: 266 ----VSSEDAVNMARVLALKEGLMVGISSGANTVAAL 298 >4OFX-A nrPDB Length = 319 Score = 178 bits (451), Expect = 3e-45, Method: Composition-based stats. Identities = 65/294 (22%), Positives = 115/294 (39%), Gaps = 28/294 (9%) Query: 17 VTPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKKGC----RHLVCSSG 72 TP++ + Q ++ KCE + P GS K R + K+G L+ + Sbjct: 15 KTPVVRLHRIGQSLPCELYGKCEFLNPGGSVKDRIGAAMIESAEKQGKIKPGDTLIEPTS 74 Query: 73 GNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEV--QLTGKVWDEANLR---A 127 GN GI A A G I +PE S + L+ GA + T +D+ A Sbjct: 75 GNTGIGIALAGAVKGYRVIITMPEKMSHEKQVVLEALGATIYRTPTEAAYDDPESHISLA 134 Query: 128 QELAKRDGWENV----PPFDHPLIWKGHASLVQELKAVLRTPPGALVLAVGGGGLLAGVV 183 + L + + ++P I + + QE+ + +V+ VG GG + GV Sbjct: 135 KRLNQEIPNSYILDQYSNAENPDI--HYQTTGQEILDDMGENLSMVVMGVGTGGTIIGVA 192 Query: 184 AGLLEVGWQHVPIIAMETHGAHCFNAAITAGKLVTLPDITSVAKSLGAKTVAARALECMQ 243 L EV + II ++ G+ LV + +G + L+ Sbjct: 193 KKLKEVN-PSIQIIGVDPIGSILGGGDEIKPYLV---------EGIGYDFI-PEVLDNNL 241 Query: 244 VCKIHSEVVEDTEAVSAVQQLLDDERMLVEPACGAALAAIYSGLLRRLQAEGCL 297 + + + D ++ ++L+ +E +LV + G+A+ A R + E CL Sbjct: 242 IDEYIK--INDKDSFLMARRLIREEGLLVGGSSGSAVWAACQAAQRLKEGERCL 293 >3PC3-A nrPDB Length = 527 Score = 176 bits (447), Expect = 9e-45, Method: Composition-based stats. Identities = 55/293 (18%), Positives = 108/293 (36%), Gaps = 21/293 (7%) Query: 18 TPLLESWAL--SQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKKGCR----HLVCSS 71 TPL++ + S ++ KCE + P GS K R Q+ ++G ++ + Sbjct: 61 TPLVKLNNIPASDGIECEMYAKCEFLNPGGSVKDRIGYRMVQDAEEQGLLKPGYTIIEPT 120 Query: 72 GGNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQ--LTGKVWDEANLR--- 126 GN GI A A G IV+PE S + V L+ GA++ T +D Sbjct: 121 SGNTGIGLAMACAVKGYKCIIVMPEKMSNEKVSALRTLGAKIIRTPTEAAYDSPEGLIYV 180 Query: 127 AQELAKRDGWENV-PPFDHPLI-WKGHASLVQELKAVLRTPPGALVLAVGGGGLLAGVVA 184 AQ+L + V + + + E+ L +V++ G G ++G+ Sbjct: 181 AQQLQRETPNSIVLDQYRNAGNPLAHYDGTAAEILWQLDNKVDMIVVSAGTAGTISGIGR 240 Query: 185 GLLEVGWQHVPIIAMETHGAHCFNAAITAGKLVTLPDITSVAKSLGAKTVAARALECMQV 244 + E I+ ++ +G+ + + D+ + V Sbjct: 241 KIKEQV-PSCQIVGVDPYGS-----ILARPAELNKTDVQFYEVEGIGYDFPPTVFDDTVV 294 Query: 245 CKIHSEVVEDTEAVSAVQQLLDDERMLVEPACGAALAAIYSGLLRRLQAEGCL 297 + D++ ++L +E +L + G A+ A + + + C+ Sbjct: 295 DVWTK--IGDSDCFPMSRRLNAEEGLLCGGSSGGAMHAALEHARKLKKGQRCV 345 >4AEC-A nrPDB Length = 430 Score = 173 bits (438), Expect = 1e-43, Method: Composition-based stats. Identities = 68/320 (21%), Positives = 122/320 (38%), Gaps = 29/320 (9%) Query: 17 VTPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKKG-----CRHLVCSS 71 TP++ ++++ + K E ++P S K R + +KG LV + Sbjct: 123 KTPMVYLNSIAKGCVANIAAKLEIMEPCCSVKDRIGYSMVTDAEQKGFISPGKSVLVEPT 182 Query: 72 GGNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTG--KVWDEANLRAQE 129 GN GI A+ A G + +P S S++ L+ GAE+ LT K A +A+E Sbjct: 183 SGNTGIGLAFIAASRGYRLILTMPASMSMERRVLLKAFGAELVLTDPAKGMTGAVQKAEE 242 Query: 130 LAKRDG-WENVPPFDHPLIWK-GHASLVQELKAVLRTPPGALVLAVGGGGLLAGVVAGLL 187 + K + FD+P K + + E+ + V +G GG + GV + Sbjct: 243 ILKNTPDAYMLQQFDNPANPKIHYETTGPEIWDDTKGKVDIFVAGIGTGGTITGVGRFIK 302 Query: 188 EVGWQHVPIIAMETHGAHCFNAAITAGKLVTLPDITSVAKSLGAKTVAARALECMQVCKI 247 E +I +E + + + + +GA + + L+ + ++ Sbjct: 303 EKN-PKTQVIGVEPTESDILSGGKPGPHKI---------QGIGAGFI-PKNLDQKIMDEV 351 Query: 248 HSEVVEDTEAVSAVQQLLDDERMLVEPACGAALAAIYSGLLRRLQAEGCLPPSLTSVVVI 307 + EA+ +QL E ++V + GAA AA R A VV Sbjct: 352 I--AISSEEAIETAKQLALKEGLMVGISSGAAAAAAIKVAKRPENA------GKLIAVVF 403 Query: 308 VCGGNNINS-RELQALKTHL 326 G S Q+++ + Sbjct: 404 PSFGERYLSTPLFQSIREEV 423 >5B1I-A nrPDB Length = 311 Score = 173 bits (437), Expect = 1e-43, Method: Composition-based stats. Identities = 58/263 (22%), Positives = 106/263 (40%), Gaps = 23/263 (8%) Query: 18 TPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKKG----CRHLVCSSGG 73 TPL+ + ++ K E P GS R + ++ ++G ++ + G Sbjct: 13 TPLMALP-IEVPNHSHIYAKLEMFNPGGSIADRLGAYLIEDGLQRGRVNAKTTIIEPTAG 71 Query: 74 NAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTG--KVWDEANLRAQELA 131 N GI A A + + +V+PE S++ +Q GAE+ T + A +A+ LA Sbjct: 72 NTGIGLALATQAHHLRTILVVPEKFSMEKQVLMQALGAEIVHTPSEEGIKGAIRKAEALA 131 Query: 132 KRDGWENVP-PFDHPLIWKGHA-SLVQELKAVLRTPPGALVLAVGGGGLLAGVVAGLLEV 189 VP F +P + +L E+ A + P A V G GG AGV A L Sbjct: 132 ATISNSYVPMQFKNPANPAAYYHTLAPEILADMPAPITAFVAGAGSGGTFAGVAAYLQAQ 191 Query: 190 GWQHVPIIAMETHGAHCFNAAITAGKLVTLPDITSVAKSLGAKTVAARALECMQVCKIHS 249 + +E G+ + G P + +G + + + +++ + + Sbjct: 192 D-SATKAVVVEPEGS-----ILNGG-----PAHAHRTEGIGVEFIPP-FFDQVRIDQ--T 237 Query: 250 EVVEDTEAVSAVQQLLDDERMLV 272 + D +A + V+ L D +L+ Sbjct: 238 LTIADNDAFAQVRHLARDHGLLI 260 >2ISQ-A nrPDB Length = 320 Score = 169 bits (428), Expect = 2e-42, Method: Composition-based stats. Identities = 64/269 (23%), Positives = 106/269 (39%), Gaps = 22/269 (8%) Query: 18 TPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKKGCRH-----LVCSSG 72 TPL+ +++ V K E ++P S K R + KKG L+ + Sbjct: 14 TPLVYLNNVAEGCVGRVAAKLEMMEPCSSVKDRIGFSMISDAEKKGLIKPGESVLIEPTS 73 Query: 73 GNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTG--KVWDEANLRAQE- 129 GN G+ A+ A G I +P S S + L G E+ LT K A +A+E Sbjct: 74 GNTGVGLAFTAAAKGYKLIITMPASMSTERRIILLAFGVELVLTDPAKGMKGAIAKAEEI 133 Query: 130 LAKRDGWENVPPFDHPLIWK-GHASLVQELKAVLRTPPGALVLAVGGGGLLAGVVAGLLE 188 LAK + F++P K + + E+ V +G GG + G L E Sbjct: 134 LAKTPNGYMLQQFENPANPKIHYETTGPEIWKGTGGKIDGFVSGIGTGGTITGAGKYLKE 193 Query: 189 VGWQHVPIIAMETHGAHCFNAAITAGKLVTLPDITSVAKSLGAKTVAARALECMQVCKIH 248 +V + +E +A ++ GK P + + +GA + L + ++ Sbjct: 194 QNA-NVKLYGVEP----VESAILSGGK----PGPHKI-QGIGAGFI-PSVLNVDLIDEVV 242 Query: 249 SEVVEDTEAVSAVQQLLDDERMLVEPACG 277 V E++ +QL E +LV + G Sbjct: 243 Q--VSSDESIDMARQLALKEGLLVGISSG 269 >4LMB-A nrPDB Length = 322 Score = 169 bits (427), Expect = 2e-42, Method: Composition-based stats. Identities = 64/280 (22%), Positives = 113/280 (40%), Gaps = 24/280 (8%) Query: 17 VTPLLESWALS--QVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKKGCRH-----LVC 69 TPL++ + + + +K E++ P+ S K R ++ G H LV Sbjct: 20 RTPLVQLNRIPVAEGVKARIVVKLESMNPAASVKDRIGVSMVEDAEAAGLIHPDKTILVE 79 Query: 70 SSGGNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTGK--VWDEANLRA 127 + GN GIA A A G + +PE+ SL+ L+ GA+++LT + A RA Sbjct: 80 PTSGNTGIALAMVAAAKGYRLVLTMPETMSLERRAMLKAYGAQLELTPGSQGMEGAITRA 139 Query: 128 QELAKRDGWEN-VPPFDHPLIWKGH-ASLVQELKAVLRTPPGALVLAVGGGGLLAGVVAG 185 +E+ + + F +P K H + +E+ A +V+ G G +A Sbjct: 140 EEIVENTPNAYSLQQFRNPANPKIHRETTAEEIWADT-DGLVDIVIGGVGTGGTITGIAE 198 Query: 186 LLEVGWQHVPIIAMETHGAHCFNAAITAGKLVTLPDITSVAKSLGAKTVAARALECMQVC 245 ++ IA+E + + + + +GA + A + Sbjct: 199 TIKPRRPQFQAIAVEPSNSPVLSGGQPGPHKI---------QGIGAGFIPAIFRPELIDE 249 Query: 246 KIHSEVVEDTEAVSAVQQLLDDERMLVEPACGAALAAIYS 285 I +V+DTEA + ++L E +L + GAAL A Sbjct: 250 VI---IVDDTEAFAYARRLARQEGLLSGISAGAALWAAIQ 286 >3X43-A nrPDB Length = 332 Score = 161 bits (406), Expect = 6e-40, Method: Composition-based stats. Identities = 58/276 (21%), Positives = 101/276 (36%), Gaps = 20/276 (7%) Query: 17 VTPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKKGC----RHLVCSSG 72 TP++ ++ V++K E+ P GS K R + KG +V + Sbjct: 13 RTPIVRLQRMAPEH-TSVYVKVESFNPGGSVKDRLALSVVLDAEAKGLLKPGDTIVECTS 71 Query: 73 GNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTGKVW--DEANLRAQEL 130 GN GIA A A G V+ ++ S++ + ++ G ++ L NL A EL Sbjct: 72 GNVGIALAMVAAARGYRFVAVMGDTYSVERRKLIRAYGGKLVLFPGHLGSKGGNLIADEL 131 Query: 131 AKRDGWENVPPFDHPLIWKGH-ASLVQELKAVLRTPPGALVLAVGGGGLLAGVVAGLLEV 189 A++ GW FD+P H + E+ A + G V +L V Sbjct: 132 AEKYGWFRARQFDNPANPSYHRETTASEILADFAGKRLDHFVTGFGTTGTLTGVGQMLRV 191 Query: 190 GWQHVPIIAMETHGAHCFNAAITAGKLVTLPDITSVAKSLGAKTVAARALECMQVCKIHS 249 V ++A+E A A + G+ A L+ + Sbjct: 192 ARPEVRVVALEPSNA----AMLARGEWSPH------QIQGLAPNFVPGVLDRSVID--DL 239 Query: 250 EVVEDTEAVSAVQQLLDDERMLVEPACGAALAAIYS 285 +++ A ++L +E + + GA +A S Sbjct: 240 VTMDEVTARDTSRRLAAEEGIFAGISAGATVATALS 275 >5XCN-X nrPDB Length = 350 Score = 160 bits (405), Expect = 7e-40, Method: Composition-based stats. Identities = 64/286 (22%), Positives = 116/286 (40%), Gaps = 19/286 (6%) Query: 2 DGPVAEHAKQEPFHVVTPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAK 61 G +A +A TPL+ V +K E PS S K R + + K Sbjct: 32 RGSMAIYADNSYSIGNTPLVRLKHF--GHNGNVVVKIEGRNPSYSVKCRIGANMVWQAEK 89 Query: 62 KGC----RHLVCSSGGNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLT- 116 G + +V ++ GN GIA AY A G T+ +PE+ SL+ + L G G + LT Sbjct: 90 DGTLTKGKEIVDATSGNTGIALAYVAAARGYKITLTMPETMSLERKRLLCGLGVNLVLTE 149 Query: 117 -GKVWDEANLRAQELAKRDGWENVP--PFDHPLIWKGH-ASLVQELKAVLRTPPGALVLA 172 K A +A+E+ D V F++P + H + E+ +V Sbjct: 150 GAKGAKGAIAKAEEIVASDPSRYVMLKQFENPANPQIHRETTGPEIWKDTDGKVDVVVAG 209 Query: 173 VGGGGLLAGVVAGLLEVGWQHVPIIAMETHGAHCFNAAITAGKLVTLPDITSVAKSLGAK 232 VG GG + G+ + + + +A+E + + + ++ P + + +GA Sbjct: 210 VGTGGSITGISRAIKLDFGKQITSVAVEPVESPVISQTLAGEEV--KPGPHKI-QGIGAG 266 Query: 233 TVAARALECMQVCKIHSEVVEDTEAVSAV-QQLLDDERMLVEPACG 277 + + + + I D++ A ++L+ +E +L + G Sbjct: 267 FI----PKNLDLSIIDRVETVDSDTALATARRLMAEEGILAGISSG 308 >4D9G-A nrPDB Length = 398 Score = 158 bits (399), Expect = 3e-39, Method: Composition-based stats. Identities = 70/341 (20%), Positives = 135/341 (39%), Gaps = 48/341 (14%) Query: 18 TPLLESWALSQVAG-MPVFLKCENVQPS-GSFKIRGIGHFCQEMAKK------------- 62 TPL L+ + G + +K E+ + +FK+ G + ++ + Sbjct: 45 TPLCALDDLANLFGVKKILVKDESKRFGLNAFKMLGGAYAIAQLLCEKYHLDIETLSFEH 104 Query: 63 ------GCRHLVCSSGGNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLT 116 ++ GN G A+AA++LG A I +P+ ++ + V + GAE +T Sbjct: 105 LKNAIGEKMTFATTTDGNHGRGVAWAAQQLGQNAVIYMPKGSAQERVDAILNLGAECIVT 164 Query: 117 GKVWDEANLRAQELAKRDGWE-----------NVPPFDHPLIWKGHASLVQELKAVLRT- 164 +D+ + A++ GWE +P + I +G+A+L E +R Sbjct: 165 DMNYDDTVRLTMQHAQQHGWEVVQDTAWEGYTKIPTW----IMQGYATLADEAVEQMREM 220 Query: 165 --PPGALVLAVGGGGLLAGVVAGLLEVGWQ-HVPIIAMETHGAHCFNAAITAGKLVTL-P 220 P ++L G G + GV+ L++V ++ I +E A C + G +V + Sbjct: 221 GVTPTHVLLQAGVGAMAGGVLGYLVDVYSPQNLHSIIVEPDKADCIYRSGVKGDIVNVGG 280 Query: 221 DITSVAKSLGAKTVAARALECMQVCKIHSEVVEDTEAVSAVQQL----LDDERMLVEPAC 276 D+ ++ L E ++ C +D+ A ++ L +D R++ + Sbjct: 281 DMATIMAGLACGEPNPLGWEILRNCATQFISCQDSVAALGMRVLGNPYGNDPRIISGESG 340 Query: 277 GAA---LAAIYSGLLRRLQAEGCLPPSLTSVVVIVCGGNNI 314 LAA++ R+ E V+VI G+ Sbjct: 341 AVGLGVLAAVHYHPQRQSLMEKLALNKDAVVLVISTEGDTD 381 >2PQM-A nrPDB Length = 343 Score = 156 bits (394), Expect = 1e-38, Method: Composition-based stats. Identities = 65/320 (20%), Positives = 117/320 (36%), Gaps = 31/320 (9%) Query: 18 TPLLESWALSQ----VAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKKGCRH----LVC 69 TPL+E +++ G + +K E P S K R + + K G ++ Sbjct: 24 TPLVELHGVTEHPRIKKGTRILVKLEYFNPMSSVKDRVGFNIVYQAIKDGRLKPGMEIIE 83 Query: 70 SSGGNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTGK--VWDEANLRA 127 S+ GN GIA A G I +P + S++ ++ GAE+ LT A Sbjct: 84 STSGNTGIALCQAGAVFGYRVNIAMPSTMSVERQMIMKAFGAELILTEGKKGMPGAIEEV 143 Query: 128 QELAKRDGWENV--PPFDHPLIWKGHASLVQELKAVLRTPPGALVLAVGGGGLLAGVVAG 185 ++ K + + F +P H E+ +V AVG G + GV Sbjct: 144 NKMIKENPGKYFVANQFGNPDNTAAHHYTANEIWEDTDGEVDIVVSAVGTSGTVIGVAEK 203 Query: 186 LLEVGWQHVPIIAMETHGAHCFNAAITAGKLVTLPDITSVAKSLGAKTVAARALECMQVC 245 L+ + + IIA+E + + + +GA + + V Sbjct: 204 -LKEKKKGIKIIAVEPEESAVLEGKAKGPHGI---------QGIGAGFIPD-IYKKEFVD 252 Query: 246 KIHSEVVEDTEAVSAVQQLLDDERMLVEPACGAALAAIYSGLLRRLQAEGCLPPSLTSVV 305 +I +D A + ++ + ++ + GAA+ A +AE T V+ Sbjct: 253 EIIPIKTQD--AWKMARAVVKYDGIMCGMSSGAAILAGLK------EAEKPENEGKTIVI 304 Query: 306 VIVCGGNNINSRELQALKTH 325 ++ G S +L +K Sbjct: 305 IVPSCGERYLSTDLYKIKDE 324 >5I7O-A nrPDB Length = 326 Score = 149 bits (375), Expect = 2e-36, Method: Composition-based stats. Identities = 66/280 (23%), Positives = 104/280 (37%), Gaps = 40/280 (14%) Query: 18 TPLLESWALSQVAG-------MPVFLKCENVQPSGSFKIRGIGHFCQEMAKKGC----RH 66 TPL+ LS + ++ K E+ P+GS K R ++ G Sbjct: 17 TPLVGLQRLSPRWDDGRDGPHVRLWAKLEDRNPTGSIKDRPAVRMIEQAEADGLLRPGAT 76 Query: 67 LVCSSGGNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTGKVW--DEAN 124 ++ + GN GI+ A AAR G V+PE+TS++ Q L+ GA++ + + A Sbjct: 77 ILEPTSGNTGISLAMAARLKGYRLICVMPENTSVERRQLLELYGAQIIFSAAEGGSNTAV 136 Query: 125 LRAQELAKRDG-WENVPPFDHPLIWKGHAS-LVQELKAVLRTPPGALVLAVGGGGLLAGV 182 A+ELA + W + + +P H EL A L V +G G L G Sbjct: 137 ATAKELAATNPSWVMLYQYGNPANTDSHYCGTGPELLADLPE-ITHFVAGLGTTGTLMGT 195 Query: 183 VAGLLEVGWQHVPIIAMETHGAHCFNA--AITAGKLVTLPDITSVAKSLGAKTVAARALE 240 L E +V I+A E A + G + L D + V Sbjct: 196 GRFLREHVA-NVKIVAAEPRYGEGVYALRNMDEGFVPELYDPEILTARYSVGAV------ 248 Query: 241 CMQVCKIHSEVVEDTEAVSAVQQLLDDERMLVEPACGAAL 280 +AV ++L+ E + + GA L Sbjct: 249 ---------------DAVRRTRELVHTEGIFAGISTGAVL 273 >3T4P-A nrPDB Length = 334 Score = 146 bits (369), Expect = 1e-35, Method: Composition-based stats. Identities = 70/321 (21%), Positives = 109/321 (33%), Gaps = 29/321 (9%) Query: 8 HAKQEPFHVVTPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKKGCRH- 66 + TP L L+ V LK E P S K R + K+G Sbjct: 12 AQSIDQLIGQTPALYLNKLNN-TKAKVVLKMECENPMASVKDRLGFAIYDKAEKEGKLIP 70 Query: 67 ----LVCSSGGNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTGK--VW 120 +V SS GN G++ A+ G I +PES SL+ L+ GAEV LT Sbjct: 71 GKSIVVESSSGNTGVSLAHLGAIRGYKVIITMPESMSLERRCLLRIFGAEVILTPAALGM 130 Query: 121 DEANLRAQELAKRDGWENV-PPFDHPLI-WKGHASLVQELKAVLRTPPGALVLAVGGGGL 178 A A+++ + + F + E+ + VG GG Sbjct: 131 KGAVAMAKKIVAANPNAVLADQFATKYNALIHEETTGPEIWEQTNHNVDCFIAGVGTGGT 190 Query: 179 LAGVVAGLLEVGWQHVPIIAMETHGAHCFNAAITAGKLVTLPDITSVAKSLGAKTVAARA 238 L GV L ++G H I+A+E + + + + +G V Sbjct: 191 LTGVARALKKMG-SHARIVAVEPTESPVLSGGKPGPHKI---------QGIGPGFVPD-V 239 Query: 239 LECMQVCKIHSEVVEDTEAVSAVQQLLDDERMLVEPACGAALAAIYSGLLRRLQAEGCLP 298 L+ + ++ +D A+ +L + + + GA + A AE Sbjct: 240 LDRSLIDEVLCVAGDD--AIETALKLTRSDGVFCGFSGGANVYAALK------IAERPEM 291 Query: 299 PSLTSVVVIVCGGNNINSREL 319 T V VI G S L Sbjct: 292 EGKTIVTVIPSFGERYLSTTL 312 >5YGR-A nrPDB Length = 404 Score = 143 bits (361), Expect = 8e-35, Method: Composition-based stats. Identities = 73/361 (20%), Positives = 131/361 (36%), Gaps = 56/361 (15%) Query: 10 KQEPFHVVTPLLESWALSQVAG-MPVFLKCENVQPS-GSFKIRGIGHFCQE--------- 58 K+ P + VTPL LSQ G + +K E+ + +FK G + + Sbjct: 38 KKLPNYAVTPLHNLAHLSQRLGLGSIHIKDESWRFGLNAFKGLGGSYAVGKYLADKLQCD 97 Query: 59 --------------MAKKGCRHLVCSSGGNAGIAAAYAARKLGIPATIVLPESTSLQVVQ 104 K V ++ GN G A+AA +LG+ A + +P+ +SL + Sbjct: 98 INSLSFAALNTPEIKEKIKDCVFVTATDGNHGRGVAWAAEQLGLKAVVYMPKGSSLIRAE 157 Query: 105 RLQGEGAEVQLTGKVWDEANLRAQELAKRDGW-----------ENVPPFDHPLIWKGHAS 153 ++ GAE +T +D+A A +A+ GW E +P + I +G+ + Sbjct: 158 NIRHHGAECTITDLNYDDAVRLAHRMAQTKGWVLLQDTAWTGYEEIPTW----IMQGYMT 213 Query: 154 LVQELKAVLRTP----PGALVLAVGGGGLLAGVVAGLLEVGWQHVP-IIAMETHGAHCFN 208 L E L P L+L G G V+ +E +++P II +E H A+C Sbjct: 214 LAVEAYEQLAETNSPLPTHLILQAGVGSFAGSVMGYFVEKMQENIPNIIVVEPHQANCLY 273 Query: 209 AAIT----AGKLVTLPDITSVAKSLGAKTVAARALECMQVCKIHSEVVEDTEAVSAVQQL 264 + VT D+ ++ L + ++ +D A ++ Sbjct: 274 QSAVMDDGQPHCVT-GDMATIMAGLACGEPNIISWPIIRDNTSCFISADDCLAAKGMRIS 332 Query: 265 LD----DERMLVEPACGAALAAIYSGLLRRL--QAEGCLPPSLTSVVVIVCGGNNINSRE 318 + + GA + L+ + Q S V++ S + Sbjct: 333 AAPRPGTDTPFISGESGAIGVGLLYELMNNMHYQDLANRLQLDASAHVLLISTEGDTSPD 392 Query: 319 L 319 + Sbjct: 393 I 393 >5B55-A nrPDB Length = 340 Score = 142 bits (357), Expect = 2e-34, Method: Composition-based stats. Identities = 55/285 (19%), Positives = 109/285 (38%), Gaps = 25/285 (8%) Query: 12 EPFHVVTPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKKGCRH----L 67 E TP+LE + +F+K E+ +GS K R + ++ +K + Sbjct: 14 ENLVGKTPMLELIFDYKGEERRIFVKNESYNLTGSIKDRMAFYTLKKAYEKNEIKKGAPI 73 Query: 68 VCSSGGNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTG---KVWDEAN 124 V ++ GN GIA + LG P I +P+ S + ++ GA++ L + + Sbjct: 74 VEATSGNTGIAFSAMGAILGHPVIIYMPDWMSEERKSLIRSFGAKIILVSRKEGGFLGSI 133 Query: 125 LRAQELAKRDGWENVP-PFDHPLIWKGHAS-LVQELKAVLRT---PPGALVLAVGGGGLL 179 + +E AK + +P F + + H + E+ +++ V VG GG + Sbjct: 134 EKTKEFAKNNPDTYLPSQFSNLYNSEAHYYGIGLEIVNEMKSLNLNIDGFVAGVGTGGTV 193 Query: 180 AGVVAGLLEVGWQHVPIIAMETHGAHCFNAAITAGKLVTLPDITSVAKSLGAKTVAARAL 239 G+ + E + + I +E + ++ G V I + + + + Sbjct: 194 MGIGKRIKE-NFSNAKICPLEPLNSP----TLSTGYKVAKHRI----EGISNEFIPDLV- 243 Query: 240 ECMQVCKIHSEVVEDTEAVSAVQQLLDDERMLVEPACGAALAAIY 284 + V+D +A+ Q+L + V + GA Sbjct: 244 --KLDKLDNVVSVDDGDAIVMAQKLAKC-GLGVGISSGANFIGAL 285 >1E5X-A nrPDB Length = 486 Score = 135 bits (339), Expect = 3e-32, Method: Composition-based stats. Identities = 56/296 (18%), Positives = 109/296 (36%), Gaps = 23/296 (7%) Query: 32 MPVFLKCENVQPSGSFKIRGIGHFCQEM-----AKKGCRHLVCSSGGNAGIAAAYAARKL 86 +++K + +GSFK G+ ++ K+ + C+S G+ A + Sbjct: 147 NDLWVKHCGISHTGSFKDLGMTVLVSQVNRLRKMKRPVVGVGCASTGDTSAALSAYCASA 206 Query: 87 GIPATIVLP-ESTSLQVVQRLQGEGAEVQLTGKVWDEANLRAQELAKRDGWENVPPFDHP 145 GIP+ + LP S+ + + GA V +D +E+ + Sbjct: 207 GIPSIVFLPANKISMAQLVQPIANGAFVLSIDTDFDGCMKLIREITAELPIYLANSL-NS 265 Query: 146 LIWKGHASLVQELKAVL-RTPPGALVLAVGGGGLLAGVVAGLL-----EVGWQHVPIIAM 199 L +G + E+ P +++ G G + G + + ++ Sbjct: 266 LRLEGQKTAAIEILQQFDWQVPDWVIVPGGNLGNIYAFYKGFKMCQELGLVDRIPRMVCA 325 Query: 200 ETHGAHCFNAAITAG----KLVTLPDITSVAKSLGAKTVAARALECMQVCKIHSEVVEDT 255 + A+ +G K +T + A +G RA+ ++ C E + Sbjct: 326 QAANANPLYLHYKSGWKDFKPMTASTTFASAIQIGDPVSIDRAVYALKKCNGIVEEATEE 385 Query: 256 EAVSAVQQLLDDERMLVEPACGAALAAIYSGLLRRLQAEGCLPPSLTSVVVIVCGG 311 E + A+ Q D M + P G AL A++ L+ +G + P+ +VVV G Sbjct: 386 ELMDAMAQ-ADSTGMFICPHTGVALTALFK-----LRNQGVIAPTDRTVVVSTAHG 435 >3VSD-A nrPDB Length = 389 Score = 100 bits (248), Expect = 1e-21, Method: Composition-based stats. Identities = 59/298 (19%), Positives = 113/298 (37%), Gaps = 36/298 (12%) Query: 18 TPLLESWALSQVAGMPVFLKCENVQP-SGSFKIRGIGHFCQEMAKKGCRH--LVCSSGGN 74 TPL+ S L G+ V+LK E P S S R ++++ + + ++ N Sbjct: 97 TPLVRS-RLQLPNGVRVWLKLEWYNPFSLSVADRPAVEIISRLSRRVEKGSLVADATSSN 155 Query: 75 AGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTGKVWDEANLRAQEL--AK 132 G+A + AR G A + LP + + GA+V + + +L + + +K Sbjct: 156 FGVALSAVARLYGYRARVYLPGAAEEFGKLLPRLLGAQVIVDPEAPSTVHLLPRVMKDSK 215 Query: 133 RDGWENVPPFDHPLIWKGHAS-LVQELKAVL---RTPPGALVLAVGGGGLLAGVVAGLLE 188 +G+ +V F + ++ H +E+ + ++G G ++ L Sbjct: 216 NEGFVHVNQFYNDANFEAHMRGTAREIFVQSRRGGLALRGVAGSLGTSGHMSAAAFYLQS 275 Query: 189 VGWQHVPIIAMETHGAHCFNAAITAGKLVTLPDITSVAKSLGAKTVAARALECMQVCKIH 248 V + + ++ ++P I V + + L+ Sbjct: 276 VD-PSIRAVLVQPAQGD------------SIPGIRRVETGM----LWINMLDISYT---- 314 Query: 249 SEVVEDTEAVSAVQQLLDDERMLVEPACGAALAAIYSGLLRRLQAEGCLPPSLTSVVV 306 V EA+ AV ++ + +++ P+ GAA L + AEG L P VVV Sbjct: 315 LAEVTLEEAMEAVVEVARSDGLVIGPSGGAA-----VKALAKKAAEGDLEPGDYVVVV 367 >5EY5-B nrPDB Length = 399 Score = 94.5 bits (233), Expect = 5e-20, Method: Composition-based stats. Identities = 59/318 (18%), Positives = 112/318 (35%), Gaps = 47/318 (14%) Query: 18 TPLLESWALSQVAG-MPVFLKCENVQPSGSFKIRGIGHFCQEMAKKGCRHLVCSS-GGNA 75 TPL + L++ G ++LK E++ +G+ KI + G + ++ + G Sbjct: 51 TPLYFAENLTKDLGGAKIYLKREDLNHTGAHKINNALGQALLAKRMGKKRVIAETGAGQH 110 Query: 76 GIAAAYAARKLGIPATIVLPESTSLQVVQR-----LQGEGAEVQLT---GKVWDEANLRA 127 G+A A A G+ + + Q ++ GA+V+ + +A A Sbjct: 111 GVATATVAAMFGLECVVYM--GAEDIERQALNVFRMKLLGAKVRPVTSGSRTLKDAINEA 168 Query: 128 QE---LAKRDGWENVPPFDHPL-----IWKGHASLVQELKAVLRTP----PGALVLAVGG 175 D + + P + + + +E + + P A+V VGG Sbjct: 169 MRDWVTNVEDTFYIIGSVVGPHPYPMMVRDFQSVIGEEARQQILEKEGRLPDAIVACVGG 228 Query: 176 GGLLAGVVAGLLEVGWQHVPIIAMETHGAHCF----NAAITAGKLVTLP----------- 220 G G+ ++ + V +I +E G A ++AG+ L Sbjct: 229 GSNAMGIFHPFID--DESVRLIGVEAAGKGIETGKHAATLSAGRPGVLHGAMTYLLQDED 286 Query: 221 ----DITSVAKSLGAKTVAARALECMQVCKIHSEVVEDTEAVSAVQQLLDDERML--VEP 274 + S++ L V + V D EA+ A Q L E ++ +E Sbjct: 287 GQIIEAHSISAGLDYPGVGPEHAYLKDTGRAEYVSVTDDEALEAFQLLSRTEGIIPALES 346 Query: 275 ACGAALAAIYSGLLRRLQ 292 + A A + L + Q Sbjct: 347 SHAVAYAMKLAPELSKDQ 364 >5OCW-B nrPDB Length = 442 Score = 92.2 bits (227), Expect = 3e-19, Method: Composition-based stats. Identities = 61/307 (19%), Positives = 106/307 (34%), Gaps = 41/307 (13%) Query: 18 TPLLESWALSQVAG-MPVFLKCENVQPSGSFKIRGIGHFCQEMAKKGCRHLVCSS-GGNA 75 +PL E+ LSQ AG +FLK E++ +GS KI + + G ++ + G Sbjct: 102 SPLYEATRLSQHAGSARIFLKREDLNHTGSHKINNVLGQALLARRMGKTRVIAETGAGQH 161 Query: 76 GIAAAYAARKLGIPATIVL---PESTSLQVVQRLQGEGAEVQLTG-----------KVWD 121 G+A A A LG+ I + + V R++ GAEV + + Sbjct: 162 GVATATACALLGLDCVIYMGGIDTARQALNVARMRLLGAEVVAVQTGSKTLKDAINEAFR 221 Query: 122 EANLRAQELAKRDGWENVPPFDHPLIWKGHASLVQELKAVLRTP----PGALVLAVGGGG 177 + A G P ++ + E + ++ P A+V VGGG Sbjct: 222 DWVANADNTYYCFGTAAGPHPFPTMVRDFQRIIGMEARVQIQGQAGRLPDAVVACVGGGS 281 Query: 178 LLAGVVAGLLEVGWQHVPIIAMETHG--------AHCFNAA-----------ITAGKLVT 218 G+ L+ V ++ E G A F A + + Sbjct: 282 NAIGIFHAFLD--DPGVRLVGFEAAGDGVETGRHAATFTAGSPGAFHGSFSYLLQDEDGQ 339 Query: 219 LPDITSVAKSLGAKTVAARALECMQVCKIHSEVVEDTEAVSAVQQLLDDERMLVEPACGA 278 + S++ L V + ++ + D+EA+ A L E ++ Sbjct: 340 TIESHSISAGLDYPGVGPEHAWLKEAGRVDYRPITDSEAMDAFGLLCRMEGIIPAIESAH 399 Query: 279 ALAAIYS 285 A+A Sbjct: 400 AVAGALK 406 >5KIN-B nrPDB Length = 407 Score = 91.4 bits (225), Expect = 5e-19, Method: Composition-based stats. Identities = 69/340 (20%), Positives = 120/340 (35%), Gaps = 55/340 (16%) Query: 18 TPLLESWALSQ-VAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKKGCRHLVCSS-GGNA 75 TPL + L+Q + G ++LK E++ +G+ KI + G + ++ + G Sbjct: 60 TPLYYAKNLTQHIGGAKIYLKREDLNHTGAHKINNALGQVWLAKRMGKKKIIAETGAGQH 119 Query: 76 GIAAAYAARKLGIPATIVLPE---STSLQVVQRLQGEGAEVQLTGKV---WDEANLRAQE 129 G+A A AA + TI + E V R++ GA+V+ +A A Sbjct: 120 GVATATAAALFNMECTIYMGEEDVKRQALNVFRMELLGAKVEAVTDGSRVLKDAVNAALR 179 Query: 130 --LAKRDGWENV-------PPFDHPLIWKGHASLVQELKAVL-----RTPPGALVLAVGG 175 +A D + PF ++ + + +E K R P ALV VGG Sbjct: 180 SWVANIDDTHYILGSALGPHPFPE-IVRDFQSVIGREAKQQYRDLTGRDLPDALVACVGG 238 Query: 176 GGLLAGVVAGLLEVGWQHVPIIAMETHG----AHCFNAAITAGKLVTLPDIT-------- 223 G G+ +E + V + E G A +T G+ L Sbjct: 239 GSNAIGLFHPFVE--DESVAMYGTEAAGLGVDTEHHAATLTKGRPGVLHGSLMDVLQDAH 296 Query: 224 -------SVAKSLGAKTVAARALECMQVCKIHSEVVEDTEAVSAVQQLLDDERML--VEP 274 S++ L + + + V D EA+ Q L E ++ +E Sbjct: 297 GQILEAFSISAGLDYPGIGPEHSHYHDIKRASYVPVTDEEALEGFQLLSRVEGIIPALES 356 Query: 275 ACGAALAAIYSGLLRRLQAEGCLPPSLTSVVVIVCGGNNI 314 + A A ++ L P + +V + G+ Sbjct: 357 SHAIAFA---------VKLAKELGPEKSMIVCLSGRGDKD 387 >6HUL-B nrPDB Length = 425 Score = 89.5 bits (220), Expect = 2e-18, Method: Composition-based stats. Identities = 63/353 (17%), Positives = 113/353 (32%), Gaps = 51/353 (14%) Query: 18 TPLLESWALSQVAG--MPVFLKCENVQPSGSFKIRGIGHFCQEMAKKGCRHLVCSS-GGN 74 TPL + L + ++ K E P+GS KI ++G H+V + G Sbjct: 76 TPLFRAKRLEEYLKTPARIYFKYEGATPTGSHKINTAIPQAYFAKEEGIEHVVTETGAGQ 135 Query: 75 AGIAAAYAARKLGIPATIVLPESTSLQ---VVQRLQGEGAEVQLTGKVWDE--------- 122 G A A AA + +TI + + + Q +Q GA V + E Sbjct: 136 WGTAVALAASMYNMKSTIFMVKVSYEQKPMRRSIMQLYGANVYASPTNLTEYGRKILETN 195 Query: 123 ---------ANLRAQELAKRDGWENVPPFDHPLIWKGHASLVQELKAV---LRTPPGALV 170 A A E A ++ + + ++ + + QE L L+ Sbjct: 196 PQHPGSLGIAMSEAIEYALKNEFRYLVGSVLDVVLLHQSVIGQETITQLDLLGEDADILI 255 Query: 171 LAVGGGGLLAGVV---------AGLLEVGWQHVPIIAM--------ETHGAHCFNAAITA 213 VGGG G + V +P + ++ G IT Sbjct: 256 GCVGGGSNFGGFTYPFIGNKKGKRYIAVSSAEIPKFSKGEYKYDFPDSAGLLPLVKMITL 315 Query: 214 GKLVTLPDITSVAKSLGAKTVAARALECMQVCKIHSEVVEDTEAVSAVQQLLDDERMLVE 273 GK P I A L VA + + + E A + ++++ ++ Sbjct: 316 GKDYVPPPI--YAGGLRYHGVAPTLSLLTKEGIVEWREYNEREIFEAAKIFIENQGIVPA 373 Query: 274 PACGAALAAIYSGLLRRLQAEGCLPPSLTSVVVIVCGGNNINSRELQALKTHL 326 P A+ A+ + E +V + G ++ +++ L Sbjct: 374 PESAHAIRAVVDEAI-----EARKNNERKVIVFNLSGHGLLDLSNYESMMKRL 421 >6AMI-A nrPDB Length = 396 Score = 87.5 bits (215), Expect = 7e-18, Method: Composition-based stats. Identities = 61/341 (17%), Positives = 116/341 (34%), Gaps = 50/341 (14%) Query: 18 TPLLESWALS-QVAGMPVFLKCENVQPSGSFK-IRGIGHFCQEMAKKGCRHLVCSSGGNA 75 TPL + L+ ++ G V+LK E++ G+ K IG R + + G Sbjct: 51 TPLYYAKRLTEKIGGAKVYLKREDLVHGGAHKTNNAIGQALLAKFMGKTRLIAETGAGQH 110 Query: 76 GIAAAYAARKLGIPATIVLPESTSLQVVQ---RLQGEGAEVQLT---GKVWDEANLRA-Q 128 G+A A A LG+ I + + R++ GA V + +A A + Sbjct: 111 GVATAMAGALLGMKVDIYMGAEDVERQKMNVFRMKLLGANVIPVNSGSRTLKDAINEALR 170 Query: 129 ELAKRDGW--ENVPPFDHPL-----IWKGHASLVQELKAVL----RTPPGALVLAVGGGG 177 + + + P + + + +E KA + P +V VGGG Sbjct: 171 DWVATFEYTHYLIGSVVGPHPYPTIVRDFQSVIGREAKAQILEAEGQLPDVIVACVGGGS 230 Query: 178 LLAGVVAGLLEVGWQHVPIIAMETHG----AHCFNAAITAG---------------KLVT 218 G+ V + V ++ +E G + +A++ AG + Sbjct: 231 NAMGIFYPF--VNDKKVKLVGVEAGGKGLESGKHSASLNAGQVGVSHGMLSYFLQDEEGQ 288 Query: 219 LPDITSVAKSLGAKTVAARALECMQVCKIHSEVVEDTEAVSAVQQLLDDERMLVEPACGA 278 + S+A L V ++ + V D EA+ A +L E ++ Sbjct: 289 IKPSHSIAPGLDYPGVGPEHAYLKKIQRAEYVAVTDEEALKAFHELSRTEGIIPALESAH 348 Query: 279 ALAAIYSGLLRRLQAEGCLPPSLTSVVVIVCGGNNINSREL 319 A+A + E ++++ G ++ Sbjct: 349 AVAYAMKLAKEMSRDE---------IIIVNLSGRGDKDLDI 380 >4D9F-A nrPDB Length = 342 Score = 86.8 bits (213), Expect = 1e-17, Method: Composition-based stats. Identities = 55/296 (18%), Positives = 110/296 (37%), Gaps = 35/296 (11%) Query: 18 TPLLESWALSQVAGMPVFLKCENVQP--SGSFKIRGIGHFCQEMAKKGCRHLVCSSG--G 73 TPL LS G +++K ++V P G K+R + + ++G L+ + Sbjct: 33 TPLEYLPRLSDYLGREIYIKRDDVTPIAMGGNKLRKLEFLVADALREGADTLITAGAIQS 92 Query: 74 NAGIAAAYAARKLGIPATIVL--PESTSLQ------VVQRLQGEGAEVQLTGKVWDEANL 125 N A A KLG+ +L P T+ + L ++++ + + + Sbjct: 93 NHVRQTAAVAAKLGLHCVALLENPIGTTAENYLTNGNRLLLDLFNTQIEMCDAL-TDPDA 151 Query: 126 RAQELAKRDGWENVPPFDHPLIWK------GHASLVQELKAVLRTP--PGALVLAVGGGG 177 + Q LA R + P+ P+ G+ E+ ++V+A G G Sbjct: 152 QLQTLATRIEAQGFRPYVIPVGGSSALGAMGYVESALEIAQQCEEVVGLSSVVVASGSAG 211 Query: 178 LLAGVVAGLLEVGWQHVPIIAMETHGAHCFNAAITAGKLVTLPDITSVAKSLGAKTVAAR 237 AG+ GL E V +I + + P + ++ +++ + Sbjct: 212 THAGLAVGL-EHLMPDVELIGVTVSRSVAEQ----------KPKVIALQQAIAGQLALTA 260 Query: 238 ALECMQVCKIH--SEVVEDTEAVSAVQQLLDDERMLVEPA-CGAALAAIYSGLLRR 290 + V + + AV+ L E +L++P G A+A + G+ ++ Sbjct: 261 TADIHLWDDYFAPGYGVPNDAGMEAVKLLASLEGVLLDPVYTGKAMAGLIDGISQK 316 >4NEG-A nrPDB Length = 400 Score = 86.8 bits (213), Expect = 1e-17, Method: Composition-based stats. Identities = 64/351 (18%), Positives = 125/351 (35%), Gaps = 52/351 (14%) Query: 18 TPLLESWALSQVAG-MPVFLKCENVQPSGSFKIRGIGHFCQEMAKKGCRHLVCSS-GGNA 75 TPL + +++ G ++LK E++ +G+ KI + G + +V + G Sbjct: 63 TPLYFAENMTEYCGGAKIYLKREDLNHTGAHKINNTIGQALLAVRMGKKKVVAETGAGQH 122 Query: 76 GIAAAYAARKLGIPATIVLPESTSLQVVQ---RLQGEGAEVQLTG---KVWDEANLRAQE 129 G+A A LG+ I + E + R++ GA+V+ +A A Sbjct: 123 GVATATVCALLGLECVIFMGEEDVRRQKLNVFRMELLGAKVESVAAGSGTLKDAVNEALR 182 Query: 130 --LAKRDGWENVPPFD---HP---LIWKGHASLVQELKAVL----RTPPGALVLAVGGGG 177 ++ + HP ++ + + E K P A+V +GGG Sbjct: 183 YWVSHVHDTHYIMGSVLGPHPFPQIVRDFQSVIGNETKKQYEALEGKLPEAVVACIGGGS 242 Query: 178 LLAGVVAGLLEVGWQHVPIIAMETHG----AHCFNAAITAGKLVTLP------------- 220 G+ V + V + +E G A +T G + L Sbjct: 243 NAMGMFYPF--VHDEEVALYGVEAAGKGVHTEKHAATLTKGSVGVLHGSMMYLLQNEEGQ 300 Query: 221 --DITSVAKSLGAKTVAARALECMQVCKIHSEVVEDTEAVSAVQQLLDDERMLVEPACGA 278 + S++ L V + ++ + D EA+ A Q L E ++ Sbjct: 301 IQEAHSISAGLDYPGVGPEHSLLKDIGRVSYHSITDDEALEAFQLLTKKEGIIPALESSH 360 Query: 279 ALAAIYSGLLRRLQAEGCLPPSLTSVVVIVCGGNNINSRELQALKTHLGQV 329 A+A + + EG +VI G ++++++K ++ +V Sbjct: 361 AVAYALKLAPQMKEDEG---------LVICLSGRG--DKDVESIKRYMEEV 400 >1X1Q-A nrPDB Length = 418 Score = 84.8 bits (208), Expect = 5e-17, Method: Composition-based stats. Identities = 71/353 (20%), Positives = 117/353 (33%), Gaps = 58/353 (16%) Query: 18 TPLLESWALSQV-AGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKKGCRHLVCSS-GGNA 75 TPL + LS+ G VFLK E++ +G+ KI + G R ++ + G Sbjct: 78 TPLYHAKRLSEYWGGAQVFLKREDLLHTGAHKINNTLGQALLARRMGKRRVIAETGAGQH 137 Query: 76 GIAAAYAARKLGIPATIVLPESTSLQVVQR-----LQGEGAEVQLTGKVWDEANLRAQEL 130 G++ A A G+ + + E Q ++ GAEV+ E Sbjct: 138 GVSVATVAALFGLECVVYMGEE--DVRRQALNVFRMKLLGAEVRPVAAGSRTLKDATNEA 195 Query: 131 AK------RDGWENVPPFDHPL-----IWKGHASLVQELKAV----LRTPPGALVLAVGG 175 + R + + P + + + +E+K P AL+ AVGG Sbjct: 196 IRDWITNVRTTFYILGSVVGPHPYPMMVRDFQSVIGEEVKRQSLELFGRLPDALIAAVGG 255 Query: 176 GGLLAGVVAGLLEVGWQHVPIIAMETHG----AHCFNAAITAGKLVTLPDI--------- 222 G G+ A + +I +E G A+I AGK L Sbjct: 256 GSNAIGLFAPFAYLPEGRPKLIGVEAAGEGLSTGRHAASIGAGKRGVLHGSYMYLLYDHD 315 Query: 223 ------TSVAKSLGAKTVAARALECMQVCKIHSEVVEDTEAVSAVQQLLDDERML--VEP 274 SV+ L V V D EA+ + L E ++ +E Sbjct: 316 GQITPAHSVSAGLDYPGVGPEHSYYADAGVAEYASVTDEEALEGFKLLARLEGIIPALES 375 Query: 275 ACGAALAAIYSGLLRRLQAEGCLPPSLTSVVVIVCGGNNINSRELQALKTHLG 327 A A AA + P + V+V + +++ + LG Sbjct: 376 AHAIAYAA-------------KVVPEMDKDQVVVINLSGRGDKDVTEVMRLLG 415 >5KZM-B nrPDB Length = 396 Score = 84.5 bits (207), Expect = 6e-17, Method: Composition-based stats. Identities = 57/337 (16%), Positives = 114/337 (33%), Gaps = 48/337 (14%) Query: 18 TPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKKGCRHLVCSS-GGNAG 76 T L ++ + + ++LK E++ G+ K + + G + ++ + G G Sbjct: 56 TALTKTRNIVKNTRTKLYLKREDLLHGGAHKTNQVLGQALLAKRMGKKEIIAETGAGQHG 115 Query: 77 IAAAYAARKLGIPATIVLPESTSLQ---VVQRLQGEGAEVQLT---GKVWDEANLRAQE- 129 +A A A L + + + + V R++ GAEV +A A Sbjct: 116 VATALACALLDLKCRVYMGAKDVERQSPNVFRMKLMGAEVIPVHSGSATLKDACNEALRD 175 Query: 130 ----LAKRD---GWENVPPFDHPLIWKGHASLVQELKAVL----RTPPGALVLAVGGGGL 178 +K G P ++ + + +E K + P A++ VGGG Sbjct: 176 WSANYSKAHYLLGTAAGPHPFPTIVREFQRMIGEETKQQMLAKEGRLPDAVIACVGGGSN 235 Query: 179 LAGVVAGLLEVGWQHVPIIAMET---------HGAH----------CFNAAITAGKLVTL 219 G+ A ++ ++V +I +E HGA A + + Sbjct: 236 AIGMFADFID--EKNVKLIGVEPAGKGIETGEHGAPLKHGKTGIFFGMKAPLMQNSDGQI 293 Query: 220 PDITSVAKSLGAKTVAARALECMQVCKIHSEVVEDTEAVSAVQQLLDDERMLVEPACGAA 279 + S++ L +V + + + + D EA+ A + L E ++ A Sbjct: 294 EESYSISAGLDFPSVGPQHAHLLAIGRAKYASATDDEALDAFKLLCKKEGIIPALESSHA 353 Query: 280 LAAIYSGLLRRLQAEGCLPPSLTSVVVIVCGGNNINS 316 LA P+ ++V+ G Sbjct: 354 LAHALKLAYED--------PNKEQLLVVNLSGRGDKD 382 >3SS9-X nrPDB Length = 442 Score = 81.4 bits (199), Expect = 5e-16, Method: Composition-based stats. Identities = 62/357 (17%), Positives = 114/357 (31%), Gaps = 54/357 (15%) Query: 20 LLESWALSQVAGMP--------VFLKCENVQP-SGSFKIRGI-----GHFCQEMAKKGCR 65 L+ A+ + + LK ++ P SGS K RG H + + G Sbjct: 81 LVAIPAMQKRLEKEYQQPISGQLLLKKDSHLPISGSIKARGGIYEVLAHAEKLALEAGLL 140 Query: 66 H---------------------LVCSSGGNAGIAAAYAARKLGIPATIVLPESTSLQVVQ 104 + S GN G++ + ++G T+ + Sbjct: 141 TLDDDYSKLLSPEFKQFFSQYSIAVGSTGNLGLSIGIMSARIGFKVTVHMSADARAWKKA 200 Query: 105 RLQGEGAEVQLTGKVWDEANLRAQELAKRDGW-ENVPPFDHPLIWKGHASLVQELKAVLR 163 +L+ G V + + A ++ A+ D + + ++ G++ Q LKA Sbjct: 201 KLRSHGVTVVEYEQDYGVAVEEGRKAAQSDPNCFFIDDENSRTLFLGYSVAGQRLKAQFA 260 Query: 164 TP--------PGALVLAVGGGGLLAGVVAGLLEVGWQHVPIIAMETHGAHCFNAAITAG- 214 P + L G GG GV GL HV E + C + G Sbjct: 261 QQGRIVDADNPLFVYLPCGVGGGPGGVAFGLKLAFGDHVHCFFAEPTHSPCMLLGVHTGL 320 Query: 215 -KLVTLPDIT----SVAKSLGAKTVAARALECMQVCKIHSEVVEDTEAVSAVQQLLDDER 269 +++ DI + A L + M+ + D + L +E Sbjct: 321 HDQISVQDIGIDNLTAADGLAVGRASGFVGRAMERLLDGFYTLSDQTMYDMLGWLAQEEG 380 Query: 270 MLVEPACGAALAA----IYSGLLRRLQAEGCLPPSLTSVVVIVCGGNNINSRELQAL 322 + +EP+ A +A S +++ T+ +V GG + E+ Sbjct: 381 IRLEPSALAGMAGPQRVCASVSYQQMHGFSAEQLRNTTHLVWATGGGMVPEEEMNQY 437 >1CX9-B nrPDB Length = 397 Score = 80.6 bits (197), Expect = 9e-16, Method: Composition-based stats. Identities = 60/337 (17%), Positives = 114/337 (33%), Gaps = 48/337 (14%) Query: 18 TPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKKGCRHLVCSS-GGNAG 76 T L + ++ ++LK E++ G+ K + + G ++ + G G Sbjct: 57 TALTKCQNITAGTRTTLYLKREDLLHGGAHKTNQVLGQALLAKRMGKSEIIAETGAGQHG 116 Query: 77 IAAAYAARKLGIPATIVLPESTSLQ---VVQRLQGEGAEVQLT---GKVWDEANLRAQ-- 128 +A+A A+ LG+ I + + V R++ GAEV +A A Sbjct: 117 VASALASALLGLKCRIYMGAKDVERQSPNVFRMRLMGAEVIPVHSGSATLKDACNEALRD 176 Query: 129 -----ELAK-RDGWENVPPFDHPLIWKGHASLVQELKAVLRTP----PGALVLAVGGGGL 178 E A G P ++ + + +E KA + P A++ VGGG Sbjct: 177 WSGSYETAHYMLGTAAGPHPYPTIVREFQRMIGEETKAQILDKEGRLPDAVIACVGGGSN 236 Query: 179 LAGVVAGLLEVGWQHVPIIAMETHG----AHCFNAAITAGKL---------------VTL 219 G+ A + V +I +E G A + G++ + Sbjct: 237 AIGMFADF--INDTSVGLIGVEPGGHGIETGEHGAPLKHGRVGIYFGMKAPMMQTADGQI 294 Query: 220 PDITSVAKSLGAKTVAARALECMQVCKIHSEVVEDTEAVSAVQQLLDDERMLVEPACGAA 279 + S++ L +V + + + + D EA+ A + L E ++ A Sbjct: 295 EESYSISAGLDFPSVGPQHAYLNSIGRADYVSITDDEALEAFKTLCRHEGIIPALESSHA 354 Query: 280 LAAIYSGLLRRLQAEGCLPPSLTSVVVIVCGGNNINS 316 LA + P ++V+ G Sbjct: 355 LAHALKMM--------REQPEKEQLLVVNLSGRGDKD 383 >3R0X-A nrPDB Length = 448 Score = 78.3 bits (191), Expect = 4e-15, Method: Composition-based stats. Identities = 56/324 (17%), Positives = 102/324 (31%), Gaps = 45/324 (13%) Query: 44 SGSFKIRGI-----GHFCQEMAKKGCRH---------------------LVCSSGGNAGI 77 SGS K RG H + + G + S GN G+ Sbjct: 112 SGSIKARGGIYEVLTHAEKLALEAGLLTTDDDYSVLLSPEFKQFFSQYSIAVGSTGNLGL 171 Query: 78 AAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTGKVWDEANLRAQELAKRDGW- 136 + + +G T+ + +L+ G V + A + ++ A+ D Sbjct: 172 SIGIMSACIGFKVTVHMSADARAWKKAKLRSHGVTVVEYEDDYGVAVEQGRKAAQSDPNC 231 Query: 137 ENVPPFDHPLIWKGHASLVQELKAVLRTP--------PGALVLAVGGGGLLAGVVAGLLE 188 + + ++ G+A Q LKA P + L G GG GV GL Sbjct: 232 FFIDDENSRTLFLGYAVAGQRLKAQFAQQGRVVDASHPLFVYLPCGVGGGPGGVAFGLKL 291 Query: 189 VGWQHVPIIAMETHGAHCFNAAITAG--KLVTLPDIT----SVAKSLGAKTVAARALECM 242 +V E + C + G +++ DI + A L + M Sbjct: 292 AFGDNVHCFFAEPTHSPCMLLGVYTGLHDAISVQDIGIDNLTAADGLAVGRASGFVGRAM 351 Query: 243 QVCKIHSEVVEDTEAVSAVQQLLDDERMLVEPACGAALAA----IYSGLLRRLQAEGCLP 298 + ++D + L +E + +EP+ A +A S ++ Sbjct: 352 ERLLDGLYTLDDQTMYDMLGWLAQEEGIRLEPSALAGMAGPQRICASVAYQQRHGFSQTQ 411 Query: 299 PSLTSVVVIVCGGNNINSRELQAL 322 + +V GG + E++ Sbjct: 412 LGNATHLVWATGGGMVPEDEMEQY 435 >1RQX-A nrPDB Length = 338 Score = 74.8 bits (182), Expect = 5e-14, Method: Composition-based stats. Identities = 61/284 (21%), Positives = 99/284 (34%), Gaps = 34/284 (11%) Query: 18 TPLLESWALSQVAGMPV--FLKCENVQPSGSF---KIRGIGHFCQEMAKKGCRHLVCSSG 72 TP+ LS+ G V + K E+ +F K R + + E +GC LV G Sbjct: 16 TPIQPLARLSKHLGGKVHLYAKREDCNSGLAFGGNKTRKLEYLIPEALAQGCDTLVSIGG 75 Query: 73 --GNAGIAAAYAARKLGIPATIVLPESTS--------LQVVQRLQGEGAEVQLTGKVWDE 122 N A A LG+ +V + + +Q + GA+V+L +D Sbjct: 76 IQSNQTRQVAAVAAHLGMKCVLVQENWVNYSDAVYDRVGNIQMSRILGADVRLVPDGFDI 135 Query: 123 ANLR----AQELAKRDGW--ENVPP--FDHPLIWKGHASLVQELKAV---LRTPPGALVL 171 R A E + G +P DHPL G +E++A L +V+ Sbjct: 136 GFRRSWEDALESVRAAGGKPYAIPAGCSDHPLGGLGFVGFAEEVRAQEAELGFKFDYVVV 195 Query: 172 AVGGGGLLAGVVAGLLEVGWQHVPIIAMETHGAHCFNAAITAGKLVTLPDITSVAKSLGA 231 G AG+V G G A G + +T A+ +G Sbjct: 196 CSVTGSTQAGMVVGFAADG------RADRVIGVDASAKPAQTREQITRI-ARQTAEKVGL 248 Query: 232 KTVAARA-LECMQVCKIHSEVVEDTEAVSAVQQLLDDERMLVEP 274 + RA + + + + + A++ E ML +P Sbjct: 249 ERDIMRADVVLDERFAGPEYGLPNEGTLEAIRLCARTEGMLTDP 292 >1J0B-A nrPDB Length = 325 Score = 72.1 bits (175), Expect = 3e-13, Method: Composition-based stats. Identities = 58/269 (21%), Positives = 106/269 (39%), Gaps = 22/269 (8%) Query: 18 TPLLESWALSQVAGMPVFLKCENVQ--PSGSFKIRGIGHFCQEMAKKGCRHLVCSSG--G 73 TP+ +S+ G V++K +++ G KIR + + + KG ++ Sbjct: 22 TPIQYLPNISREIGADVYIKRDDLTGLGIGGNKIRKLEYLLGDALSKGADVVITVGAVHS 81 Query: 74 NAGIAAAYAARKLGIPATIVLPESTSLQVVQRL-QGEGAEVQLTG-----KVWDEANLRA 127 N AA+KLG+ A +VL L+ L + G E ++ ++ A A Sbjct: 82 NHAFVTGLAAKKLGLDAILVLRGKEELKGNYLLDKIMGIETRVYDAKDSFELMKYAEEIA 141 Query: 128 QELAK--RDGWENVPPFDHPLIWKGHASLVQELKAVLRTPPGALVLAVGGGGLLAGVVAG 185 +EL + R + P P+ G+ V E+ ++V+A G GG LAG+ G Sbjct: 142 EELKREGRKPYVIPPGGASPIGTLGYVRAVGEIATQSEVKFDSIVVAAGSGGTLAGLSLG 201 Query: 186 LLEVGWQHVPIIAMETHGAHCFNAAITAGKLVTLPDITSVAKSLGAKTVAARALECMQVC 245 L + + + + + A + KL L I A+ LG K E Sbjct: 202 L-SILNEDIRPVGI----AVGRFGEVMTSKLDNL--IKEAAELLGVK--VEVRPELYDYS 252 Query: 246 KIHSEVVEDTEAVSAVQQLLDDERMLVEP 274 + E ++++ E ++++P Sbjct: 253 FGEYGKIT-GEVAQIIRKVGTREGIILDP 280 >6EQN-B nrPDB Length = 425 Score = 69.1 bits (167), Expect = 3e-12, Method: Composition-based stats. Identities = 55/340 (16%), Positives = 100/340 (29%), Gaps = 52/340 (15%) Query: 18 TPLLESWALSQVAG--MPVFLKCENVQPSGSFKIRGIGHFCQEMAKKGCRHLVCSS-GGN 74 TP++ + L + G + ++LK E+ +GS KI + + + G Sbjct: 76 TPIIRAKRLEEYLGNNIKIYLKMESYTYTGSHKINSALAHVYYAKLDNAKFVTTETGAGQ 135 Query: 75 AGIAAAYAARKLGIPATIVLPES---TSLQVVQRLQGEGAEVQLTGKVWDE--------- 122 G + A A+ + A I + + +Q GAEV + E Sbjct: 136 WGSSVALASALFRMKAHIFMVRTSYYAKPYRKYMMQMYGAEVHPSPSDLTEFGRQLLAKD 195 Query: 123 ---------ANLRAQELAKRDGWENVPPFDHPLIWKGHASLVQELKAVL---RTPPGALV 170 A A E A ++G + V E K + P ++ Sbjct: 196 SNHPGSLGIAISDAVEYAHKNGGKYVVGSVVNSDIMFKTIAGMEAKKQMELIGEDPDYII 255 Query: 171 LAVGGGGLLAGVVAGLLEVGWQHVPIIAMETHGAHCFNAAITAG-KLVTLPDITSVAKSL 229 VGGG A + L + + +T G PD + L Sbjct: 256 GVVGGGSNYAALAYPFLGDELRSGKVRRKYIASGSSEVPKMTKGVYKYDYPDTAKLLPML 315 Query: 230 GAKTVAARALE-----------------CMQVCKIHSEVVE--DTEAVSAVQQLLDDERM 270 T+ + + + + K + + E+ + + E Sbjct: 316 KMYTIGSDFVPPPVYAGGLRYHGVAPTLSLLISKGIVQARDYSQEESFKWAKLFSELEGY 375 Query: 271 LVEPACGAALAAIYSGLLRRLQAEGCLPPSLTSVVVIVCG 310 + P AL +L + E +V+V G Sbjct: 376 IPAPETSHAL-----PILAEIAEEAKKSGERKTVLVSFSG 410 >1VB3-A nrPDB Length = 428 Score = 58.7 bits (140), Expect = 3e-09, Method: Composition-based stats. Identities = 39/262 (14%), Positives = 74/262 (28%), Gaps = 23/262 (8%) Query: 43 PSGSFKI---RGIGHFCQEMAKKGCRHLVCSSGGNAGIAAAYAARKL-GIPATIVLPES- 97 P+ +FK R + +A ++ ++ G+ G A A+A L + I+ P Sbjct: 102 PTLAFKDFGGRFMAQMLTHIAGDKPVTILTATSGDTGAAVAHAFYGLPNVKVVILYPRGK 161 Query: 98 TSLQVVQRLQGEGAEV--QLTGKVWDEANLRAQELAKRDGWE-----NVPPFDHPLIWKG 150 S + G + +D ++ + + N + Sbjct: 162 ISPLQEKLFCTLGGNIETVAIDGDFDACQALVKQAFDDEELKVALGLNSANSINISRLLA 221 Query: 151 HASLVQELKAVLRTPPGALVLAVGGGGLLAGVVAGL--LEVGWQHVPIIAMETHGAHCFN 208 E A L ++ G + AGL +G IA Sbjct: 222 QICYYFEAVAQLPQETRNQLVVSVPSGNFGDLTAGLLAKSLGLPVKRFIAATNVN-DTVP 280 Query: 209 AAITAGK--LVTLPDITSVAKSLGAKTVAARALECMQVCKIHSE-----VVEDTEAVSAV 261 + G+ S A + R E + + V+D + Sbjct: 281 RFLHDGQWSPKATQATLSNAMDVSQPNNWPRVEELFRRKIWQLKELGYAAVDDETTQQTM 340 Query: 262 QQLLDDERMLVEPACGAALAAI 283 ++L + EP A A+ Sbjct: 341 REL-KELGYTSEPHAAVAYRAL 361 >2VCY-A nrPDB Length = 344 Score = 34.0 bits (76), Expect = 0.10, Method: Composition-based stats. Identities = 16/73 (21%), Positives = 29/73 (39%), Gaps = 1/73 (1%) Query: 55 FCQEMAKKGCRHLVCSSGGNAGIAAAYAARKLGIPATIVLPESTSLQVV-QRLQGEGAEV 113 E + G + +S G A A LG+ V+ + +Q + RL+ GAE Sbjct: 147 MDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEH 206 Query: 114 QLTGKVWDEANLR 126 +T + ++ Sbjct: 207 VITEEELRRPEMK 219 >2KU2-A nrPDB Length = 237 Score = 31.3 bits (69), Expect = 0.54, Method: Composition-based stats. Identities = 21/106 (19%), Positives = 40/106 (37%), Gaps = 4/106 (3%) Query: 125 LRAQELAKRDGWENVPPFDHPLIWKGHASLVQEL--KAVLRTPPGALVLAVGGGGLLAGV 182 A ++ + + V P+ LI+ G + L T A+G G V Sbjct: 119 RVADQMQQYTQYGGVRPYGVSLIFAGIDQIGPRLFDCDPAGTINEYKATAIGSGK--DAV 176 Query: 183 VAGLLEVGWQHVPIIAMETHGAHCFNAAITAGKLVTLPDITSVAKS 228 V+ L +++P T G +++ G+ + P+I S+ Sbjct: 177 VSFLEREYKENLPEKEAVTLGIKALKSSLEEGEELKAPEIASITVG 222 >1T8T-A nrPDB Length = 271 Score = 30.9 bits (68), Expect = 0.71, Method: Composition-based stats. Identities = 15/75 (20%), Positives = 22/75 (29%), Gaps = 7/75 (9%) Query: 152 ASLVQELKAVLRTPPGALVLAVGGGGLLAGVVAGLLEVG--WQHVPIIAMETHGAHCFNA 209 +L L + P A+++ V GG LLE V + E H Sbjct: 4 GTLALLLDEGSKQLPQAIIIGVKKGGT-----RALLEFLRVHPDVRAVGAEPHFFDRSYD 58 Query: 210 AITAGKLVTLPDITS 224 A +P Sbjct: 59 KGLAWYRDLMPRTLD 73 >1G5T-A nrPDB Length = 196 Score = 30.1 bits (66), Expect = 1.2, Method: Composition-based stats. Identities = 22/97 (22%), Positives = 32/97 (32%), Gaps = 7/97 (7%) Query: 42 QPSGSFKIRGIGHFCQEMAKKGCRHLVCSSG-GNAGIAAAYAARKLG----IPATIVLPE 96 Q K R Q ++G + +G G A AAR +G + + Sbjct: 8 QRQQKVKDRVDARVAQAQEERGIIIVFTGNGKGKTTAAFGTAARAVGHGKNVGVVQFIKG 67 Query: 97 STSLQVVQRLQGEGAE--VQLTGKVWDEANLRAQELA 131 + L+ G E V TG W+ N A A Sbjct: 68 TWPNGERNLLEPHGVEFQVMATGFTWETQNREADTAA 104 >1FGS-A nrPDB Length = 428 Score = 29.8 bits (65), Expect = 1.5, Method: Composition-based stats. Identities = 26/149 (17%), Positives = 42/149 (28%), Gaps = 17/149 (11%) Query: 118 KVWDEANLRAQELAKRDGWENVPPFDHPLIWKGHASLVQELKAVLRTPPGALVLAVGGGG 177 + A A+ AK+ W P + H E + P ++ Sbjct: 263 RNMAIAIQTAKVYAKQTEWPLTPQNIRQGLAASHWPARLE---KISDTPLIVIDGAHNPD 319 Query: 178 LLAGVVAGLLEVGWQHVPIIAMETHG------AHCFNAA-------ITAGKLVTLPDITS 224 + G++ L ++ Q + +IA A AA G LP+ Sbjct: 320 GINGLITALKQLFSQPITVIAGILADKDYAAMADRLTAAFSTVYLVPVPGTPRALPEAGY 379 Query: 225 VAKSLG-AKTVAARALECMQVCKIHSEVV 252 A G K AL +V Sbjct: 380 EALHEGRLKDSWQEALAASLNDVPDQPIV 408 >3UI2-A nrPDB Length = 244 Score = 29.0 bits (63), Expect = 3.0, Method: Composition-based stats. Identities = 11/43 (25%), Positives = 20/43 (46%) Query: 100 LQVVQRLQGEGAEVQLTGKVWDEANLRAQELAKRDGWENVPPF 142 +VV+ L GA++++ + A A+E+ K N F Sbjct: 124 PEVVEALVELGADIEVEDERGLTALELAREILKTTPKGNPMQF 166 >3DEO-A nrPDB Length = 183 Score = 29.0 bits (63), Expect = 3.0, Method: Composition-based stats. Identities = 11/43 (25%), Positives = 20/43 (46%) Query: 100 LQVVQRLQGEGAEVQLTGKVWDEANLRAQELAKRDGWENVPPF 142 +VV+ L GA++++ + A A+E+ K N F Sbjct: 123 PEVVEALVELGADIEVEDERGLTALELAREILKTTPKGNPMQF 165 >1V6S-A nrPDB Length = 390 Score = 28.6 bits (62), Expect = 3.7, Method: Composition-based stats. Identities = 32/128 (25%), Positives = 42/128 (32%), Gaps = 30/128 (23%) Query: 83 ARKLGIPATIVLPEST-SLQVVQR---LQGEGAEVQLT-------GKVWDEANLRAQELA 131 A LG+ + LPE + + ++ + A G EA RA E A Sbjct: 250 AEALGVR--VYLPEDVVAAERIEAGVETRVFPARAIPVPYMGLDIGPKTREAFARALEGA 307 Query: 132 KRD------GWENVPPFDHPLIWKGHASLVQELKAVLRTPPGALVLAVGGGGLLAGVVA- 184 + G VPPFD + G A E VGGG +A V Sbjct: 308 RTVFWNGPMGVFEVPPFDEGTLAVGQAIAALE----------GAFTVVGGGDSVAAVNRL 357 Query: 185 GLLEVGWQ 192 GL E Sbjct: 358 GLKERFGH 365 >4RVS-A nrPDB Length = 329 Score = 28.6 bits (62), Expect = 3.8, Method: Composition-based stats. Identities = 13/56 (23%), Positives = 24/56 (42%), Gaps = 3/56 (5%) Query: 60 AKKGCRHLVCSSGGNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQL 115 K+G LV + G G+ A LG+ + ++ + + + GA+V L Sbjct: 140 VKRGDTVLVHAGAGGVGLILTQWATHLGVRVITTV---STAEKAKLSKDAGADVVL 192 >6DV6-A nrPDB Length = 562 Score = 28.6 bits (62), Expect = 4.2, Method: Composition-based stats. Identities = 15/90 (16%), Positives = 26/90 (28%) Query: 177 GLLAGVVAGLLEVGWQHVPIIAMETHGAHCFNAAITAGKLVTLPDITSVAKSLGAKTVAA 236 G+ + L I++ E F+A GK S+ ++L A Sbjct: 206 GIATAIERLLQGEEQPLGNIVSSEPPAMPAFSANGEKGKAANYAGGMSLQEALKQNAAAG 265 Query: 237 RALECMQVCKIHSEVVEDTEAVSAVQQLLD 266 V E V ++ L+ Sbjct: 266 NIKIVAYPDTNSLLVKGTAEQVHFIEMLVK 295 >4MUZ-A nrPDB Length = 229 Score = 28.2 bits (61), Expect = 4.6, Method: Composition-based stats. Identities = 12/54 (22%), Positives = 20/54 (37%), Gaps = 1/54 (1%) Query: 20 LLESWALSQVAGMPVFLKCENVQPSG-SFKIRGIGHFCQEMAKKGCRHLVCSSG 72 L E +++ G V+ E P G F ++ + GC L+ S Sbjct: 113 LREVCRVAEEFGGKVYAVTELSSPGGEEFMSAVSLKIVEKAKEAGCHGLIAPST 166 >2PNF-A nrPDB Length = 248 Score = 28.2 bits (61), Expect = 5.0, Method: Composition-based stats. Identities = 16/52 (30%), Positives = 24/52 (46%), Gaps = 4/52 (7%) Query: 44 SGSFKIRGIGHFC-QEMAKKGCRHLVCSSGGNAGIAAA-YAARKLGIPATIV 93 +GS RGIG +++A G ++ + G A A A K G+ A V Sbjct: 13 TGST--RGIGRAIAEKLASAGSTVIITGTSGERAKAVAEEIANKYGVKAHGV 62 >1ZOS-A nrPDB Length = 230 Score = 28.2 bits (61), Expect = 5.6, Method: Composition-based stats. Identities = 14/88 (15%), Positives = 28/88 (31%), Gaps = 1/88 (1%) Query: 131 AKRDGWENVPPFDHPLIWKGHASLVQELKAVLRT-PPGALVLAVGGGGLLAGVVAGLLEV 189 G+ PL ++ + V +++ L + + G + + Sbjct: 102 VTAFGYAYGQMAQQPLYFESDKTFVAQIQESLSQLDQNWHLGLIATGDSFVAGNDKIEAI 161 Query: 190 GWQHVPIIAMETHGAHCFNAAITAGKLV 217 ++A+E GA AA T V Sbjct: 162 KSHFPEVLAVEMEGAAIAQAAHTLNLPV 189 >5C8D-A nrPDB Length = 305 Score = 27.8 bits (60), Expect = 7.1, Method: Composition-based stats. Identities = 18/80 (22%), Positives = 27/80 (33%), Gaps = 4/80 (5%) Query: 50 RGIGHFCQEMAKKGCRHLVCSSGGN-AGIAAAYAA---RKLGIPATIVLPESTSLQVVQR 105 R G LV + G I A AA R+ G+PA + P++ + Sbjct: 171 RLQELLDLAGFPPGPPVLVTTPPGERHEIGAMLAAYHLRRKGVPALYLGPDTPLPDLRAL 230 Query: 106 LQGEGAEVQLTGKVWDEANL 125 + GA + V E Sbjct: 231 ARRLGAGAVVLSAVLSEPLR 250 >6OMZ-A nrPDB Length = 293 Score = 27.5 bits (59), Expect = 8.2, Method: Composition-based stats. Identities = 28/165 (16%), Positives = 50/165 (30%), Gaps = 36/165 (21%) Query: 42 QPSGSFKIRGIGHFCQEMAKKGCRHLVCSSGGNAGIAAAYAARKL--------------- 86 QP ++ G+ + Q+ G + + G+A A ++ Sbjct: 17 QPGTPVQVMGVVNVTQDSFSDGGKFIDTDRAVEHGLALVAAGAQIIDVGGESTRPGATRI 76 Query: 87 --GIPATIVLP--------------ESTSLQVVQRLQGEGAEVQLTGKVWDEANLRAQEL 130 G+ A V P ++ V + GA + A L Sbjct: 77 DPGVEAARVTPVIRELAAQGITISIDTMHADVARAALEAGAHIVNDVSGGRADPGMAGVL 136 Query: 131 AK-RDGWENVP----PFDHPLIWKGHASLVQELKAVLRTPPGALV 170 A+ + W + DHP G+ +V E++ L A V Sbjct: 137 AEAKVPWILMHWRSVDADHPHRVPGYRDVVAEVRTELLAAVDAAV 181 >5C8A-A nrPDB Length = 206 Score = 27.5 bits (59), Expect = 8.6, Method: Composition-based stats. Identities = 18/80 (22%), Positives = 27/80 (33%), Gaps = 4/80 (5%) Query: 50 RGIGHFCQEMAKKGCRHLVCSSGGN-AGIAAAYAA---RKLGIPATIVLPESTSLQVVQR 105 R G LV + G I A AA R+ G+PA + P++ + Sbjct: 72 RLQELLDLAGFPPGPPVLVTTPPGERHEIGAMLAAYHLRRKGVPALYLGPDTPLPDLRAL 131 Query: 106 LQGEGAEVQLTGKVWDEANL 125 + GA + V E Sbjct: 132 ARRLGAGAVVLSAVLSEPLR 151 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.308 0.124 0.297 Lambda K H 0.267 0.0383 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 10,199,310 Number of Sequences: 36641 Number of extensions: 351509 Number of successful extensions: 1742 Number of sequences better than 10.0: 95 Number of HSP's better than 10.0 without gapping: 130 Number of HSP's successfully gapped in prelim test: 40 Number of HSP's that attempted gapping in prelim test: 1345 Number of HSP's gapped (non-prelim): 179 length of query: 329 length of database: 10,336,785 effective HSP length: 97 effective length of query: 232 effective length of database: 6,782,608 effective search space: 1573565056 effective search space used: 1573565056 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.2 bits) S2: 59 (27.4 bits)